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Archive, 2021-06

2 Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells
Peng, D.; Ando, K.; Gloger, M.; Skoczylas, R.; Mochizuki, N.; Betsholtz, C.; Fukuhara, S.; Koltowska, K.
10.1101/2021.06.30.450504 — developmental biology — Posted on 2021-06-30
3 Rewiring the Three-Carbon Metabolism Abrogates Multiple MAPK-Induced Cellular Dysfunctions During Metabolic Disorder
Dube, A. K.; Malenfant, N.; Ladonne, F.; Piano, A.; Mohammad, K.; Belanger, M.; Begin, F.; Lebel-Guay, F.; Titorenko, V. I.; Bourbonnais, Y.
10.1101/2021.06.30.450468 — cell biology — Posted on 2021-06-30
5 Evolution of a minimal cell
Lennon, J. T.; Moger-Reischer, R. Z.; Glass, J. I.; Wise, K.; Bittencourt, D.; Sun, L.; Lynch, M.
10.1101/2021.06.30.450565 — evolutionary biology — Posted on 2021-06-30
6 A Comprehensive Overview of the Physical Health of the Adolescent Brain Cognitive Development Study (ABCD) Cohort at Baseline
Palmer, C. E.; Sheth, C.; Marshall, A.; Adise, S.; Baker, F.; Chang, L.; Clark, D.; Dagher, R.; Dowling, G.; Gonzalez, M.; Haist, F.; Herting, M.; Huber, R.; Jernigan, T.; LeBlanc, K.; Lee, K.; Lisdahl, K.; Neigh, G.; Patterson, M.; Renshaw, P.; Rhee, K.; Tapert, S.; Thompson, W.; Uban, K.; Sowell, E.; Yurgelun-Todd, D.
10.1101/2021.06.30.450555 — developmental biology — Posted on 2021-06-30
8 CellProfiler 4: Improvements in Speed, Utility and Usability
Stirling, D. R.; Swain-Bowden, M. J.; Lucas, A. M.; Carpenter, A. E.; Cimini, B. A.; Goodman, A.
10.1101/2021.06.30.450416 — cell biology — Posted on 2021-06-30
11 Co-localization of different Neurotransmitter Transporters on the same Synaptic Vesicle is Bona-fide yet Sparse
Upmanyu, N.; Jin, J.; Ganzella, M.; Boesche, L.; Malviya, V. N.; Zhuleku, E.; Politi, A.; Ninov, M.; Silbern, I.; Urlaub, H.; Riedel, D.; Preobraschenski, J.; Milosevic, I.; Jahn, R.; Sambandan, S.
10.1101/2021.06.30.449903 — neuroscience — Posted on 2021-06-30
12 Computational modeling predicts acidic microdomains in the glutamatergic synaptic cleft
Feghhi, T.; Hernandez, R. X.; Stawarski, M.; Thomas, C. I.; Kamasawa, N.; Lau, A. W. C.; Macleod, G. T.
10.1101/2021.06.30.450624 — neuroscience — Posted on 2021-06-30
15 Membraneless organelles formed by liquid-liquid phase separation increase bacterial fitness
Jin, X.; Lee, J.-E.; Schaefer, C.; Luo, X.; Wollman, A. J.; Tian, T.; Zhang, X.; Chen, X.; Li, Y.; Leake, M. C.; Bai, F. C.
10.1101/2021.06.24.449778 — biophysics — Posted on 2021-06-30
18 Parametric modulators of sex-biased conditioned fear responding
Mitchell, J. R.; Trettel, S. G.; Li, A. J.; Wasielewski, S.; Huckleberry, K. A.; Fanikos, M.; Golden, E.; Shansky, R. M.
10.1101/2021.06.30.450556 — animal behavior and cognition — Posted on 2021-06-30
20 Force generation of KIF1C is impaired by pathogenic mutations
Siddiqui, N.; Roth, D.; Toleikis, A.; Zwetsloot, A. J.; Cross, R. A.; Straube, A.
10.1101/2021.06.30.450611 — cell biology — Posted on 2021-06-30
21 Quantitative modeling of regular retinal microglia distribution
Endo, Y.; Asanuma, D.; Namiki, S.; Hirose, K.; Uemura, A.; Kubota, Y.; Miura, T.
10.1101/2021.06.30.450549 — cell biology — Posted on 2021-06-30
23 TAILORED DC INDUCE PROTECTIVE HIV-1 SPECIFIC POLYFUNCTIONAL CD8+ T CELLS IN THE LYMPHOID TISSUE FROM HUMANIZED BLT MICE
Calvet-Mirabent, M.; Claiborne, D. T.; Deruaz, M.; Tanno, S.; Serra, C.; Delgado-Arevalo, C.; Sanchez-Cerrillo, I.; Santos, I.; Sanz, J.; Garcia-Fraile, L.; Sanchez-Madrid, F.; Alfranca, A.; Munoz-Fernandez, M. A.; Allen, T. M.; Buzon, M. J.; Balazs, A. B.; Vrbanac, V.; Martin-Gayo, E.
10.1101/2021.06.30.450486 — immunology — Posted on 2021-06-30
24 Activity-dependent LTP in the dentate gyrus promotes epileptic seizures
Nasrallah, K.; Frechou, M. A.; Yoon, Y. J.; Persaud, S.; Goncalves, T.; Castillo, P. E.
10.1101/2021.06.30.450628 — neuroscience — Posted on 2021-06-30
29 Simultaneous in vivo Pharmacokinetics and Pharmacodynamics of TDF Intravaginal Ring during High-dose Vaginal SHIV Challenge in Pigtail Macaques
Klotnik Halavaty, K.; Ott, A.; Maric, D.; Su, J.; Matias, E.; Allen, E. J.; Martin, A.; Pereira, L. E.; Deyounks, F.; Smith, J.; Kiser, P. F.; Hope, T. J.
10.1101/2021.06.29.450465 — pharmacology and toxicology — Posted on 2021-06-30
33 Cumulus cell acetyl-CoA metabolism from acetate is associated with maternal age but only partially with oocyte maturity
Anderson, S.; Xu, P.; Frey, A. J.; Goodspeed, J. R.; Doan, M. T.; Orris, J. J.; Clements, N.; Glassner, M. J.; Snyder, N. W.
10.1101/2020.02.28.970327 — biochemistry — Posted on 2021-06-30
34 Collateral damage: Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme
Lewis, M. A.; Ingham, N. A.; Chen, J.; Pearson, S.; Di Domenico, F.; Rekhi, S.; Allen, R.; Drake, M.; Willaert, A.; Rook, V.; Pass, J.; Keane, T.; Adams, D.; Tucker, A. S.; White, J. K.; Steel, K. P.
10.1101/2021.06.30.450312 — genetics — Posted on 2021-06-30
36 STEM CELL TECHNOLOGY PROVIDES NOVEL TOOLS TO UNDERSTAND HUMAN VARIATION IN Plasmodium falciparum MALARIA
Pance, A.; Ling, B.; Mwikali, K.; Koutsourakis, M.; Agu, C.; Rouhani, F.; Ponstingl, H.; Montandon, R.; Law, F.; Rayner, J. C.
10.1101/2021.06.30.450498 — cell biology — Posted on 2021-06-30
37 Horizontal Transfer of Histone H3 by Mammalian Cells
Sulkowski, P. L.; Nicholson, H. E.; Li, M. Z.; Perrimon, N.; Liu, Z.; Kaelin, W. G.
10.1101/2021.06.30.450524 — cell biology — Posted on 2021-06-30
43 Antimicrobial activity of a repurposed harmine-derived compound on extensively drug-resistant Acinetobacter baumannii clinical isolates
Breine, A.; Van Gysel, M.; Elsocht, M.; Whiteway, C.; Philippe, C.; Quinet, T.; Valcek, A.; Wouters, J.; Ballet, S.; Van der Henst, C.
10.1101/2021.06.30.450460 — microbiology — Posted on 2021-06-30
44 The development of ovine gastric and intestinal organoids for studying ruminant host-pathogen interactions
Smith, D.; Price, D. R.; Burrells, A.; Faber, M. N.; Hildersley, K. A.; Chintoan-Uta, C.; Chapuis, A. F.; Stevens, M.; Stevenson, K.; Burgess, S.; Innes, E. A.; Nisbet, A. J.; McNeilly, T. N.
10.1101/2021.06.30.450542 — microbiology — Posted on 2021-06-30
46 Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging
Huang, M. Y.; Joshi, M. B.; Boucher, M. J.; Lee, S.; Loza, L. C.; Gaylord, E. A.; Doering, T. L.; Madhani, H. D.
10.1101/2021.06.30.450566 — microbiology — Posted on 2021-06-30
47 Single-cell analyses of immune thrombocytopenic patients reveal multiorgan dissemination of high-affinity autoreactive plasma cells
Canales Herrerias, P.; Crickx, E.; Broketa, M.; Sokal, A.; Chenon, G.; Azzaoui, I.; Vandenberghe, A.; Perima, A.; Iannascoli, B.; Richard-Le Goff, O.; Castrillon, C.; Mottet, G.; Sterlin, D.; Robbins, A.; Michel, M.; England, P.; Millot, G. A.; Eyer, K.; Baudry, J.; Mahevas, M.; Bruhns, P.
10.1101/2021.06.29.450355 — immunology — Posted on 2021-06-30
51 Information Content Differentiates Enhancers From Silencers in Mouse Photoreceptors
Friedman, R. Z.; Granas, D. M.; Myers, C. A.; Corbo, J. C.; Cohen, B. A.; White, M. A.
10.1101/2021.02.05.429997 — systems biology — Posted on 2021-06-30
53 Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays
Stopsack, K. H.; Tyekucheva, S.; Wang, M.; Gerke, T. A.; Vaselkiv, J. B.; Penney, K. L.; Kantoff, P. W.; Finn, S. P.; Fiorentino, M.; Loda, M.; Lotan, T. L.; Parmigiani, G.; Mucci, L. A.
10.1101/2021.06.29.450369 — pathology — Posted on 2021-06-30
54 PhenoExam: an R package and Web application for the examination of phenotypes linked to genes and gene sets
Cisterna Garcia, A.; Gonzalez-Vidal, A.; Ruiz Villa, D.; Ortiz Murillo, J.; Gomez-Pascual, A.; Chen, Z.; Nalls, M. A.; Faghri, F.; Hardy, J.; Diez, I.; Maietta, P.; Alvarez, S.; Ryten, M.; Botia, J. A.
10.1101/2021.06.29.450324 — bioinformatics — Posted on 2021-06-30
56 Structural Insights into the Venus flytrap Mechanosensitive Ion Channel Flycatcher1
Jojoa-Cruz, S.; Saotome, K.; Tsui, C. C.; Lee, W.-H.; Sansom, M. S. P.; Murthy, S. E.; Patapoutian, A.; Ward, A. B.
10.1101/2021.06.30.449980 — biochemistry — Posted on 2021-06-30
57 Phosphorylation regulates arginine-rich RNA-binding protein solubility and oligomerization
Kundinger, S. R.; Dammer, E. B.; Yin, L.; Hurst, C.; Ping, L.; Duong, D.; Seyfried, N.
10.1101/2021.06.30.450578 — biochemistry — Posted on 2021-06-30
58 Designed architectural proteins that tune DNA looping in bacteria
Tse, D. H.; Becker, N. A.; Young, R. T.; Olson, W. K.; Peters, J. P.; Schwab, T. L.; Clark, K. J.; Maher, L. J.
10.1101/2021.06.30.450240 — biochemistry — Posted on 2021-06-30
59 Single Cell T Cell Receptor Repertoire Profiling for Dogs
Skidmore, Z. L.; Rindt, H.; Chu, S.; Fisk, B.; Fronick, C.; Fulton, R.; Zhou, M.; Bivens, N. J.; Reinero, C. N.; Griffith, M.; Bryan, J. N.; Griffith, O. L.
10.1101/2021.06.29.450365 — genomics — Posted on 2021-06-30
60 Detection of potential new SARS-CoV-2 Gamma-related lineage in Tocantins shows the spread and ongoing evolution of P.1 in Brazil
Souza, U. J. B. d.; Santos, R. N. d.; Melo, F. L.; Belmok, A.; Galvao, J. D.; Damasceno, S. B.; Rezende, T. C. V. d.; Andrade, M. d. S.; Ribeiro, B. M.; Ribeiro Junior, J. C.; Carvalho, R. F.; Oliveira, M. d. S.; Santos, I. G. C. d.; Spilki, F. R.; Campos, F. S.
10.1101/2021.06.30.450617 — genomics — Posted on 2021-06-30
68 Varenicline Prevents SARS-CoV-2 Infection In Vitro and in Rhesus Macaques
Nau, J.; Luthra, P.; Lanzer, K.; Szaba, F.; Cookenham, T.; Carlson, E.
10.1101/2021.06.29.450426 — immunology — Posted on 2021-06-30
71 The Role of Action Potential Waveform in Failure of Excitation Contraction Coupling
Wang, X.; Nawaz, M.; Burke, S. R.; Bannister, R.; Foy, B. D.; Voss, A. A.; Rich, M. M.
10.1101/2021.06.29.450361 — physiology — Posted on 2021-06-30
72 Temperature Evolution Following Joint Loading Promotes Chondrogenesis by Synergistic Cues via Calcium Signaling
Nasrollahzadeh, N.; Karami, P.; Wang, J.; Bagheri, L.; Guo, Y.; Abdel-Sayed, P.; Laurent Applegate, L.; Pioletti, D. P.
10.1101/2021.06.29.450339 — bioengineering — Posted on 2021-06-30
73 Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology
Belouzard, S.; Machelart, A.; Sencio, V.; Vausselin, T.; Hoffmann, E.; Deboosere, N.; Rouille, Y.; Desmarets, L.; Seron, K.; Danneels, A.; Robil, C.; Belloy, L.; Moreau, C.; Piveteau, C.; Biela, A.; Vandeputte, A.; Heumel, S.; Deruyter, L.; Dumont, J.; Leroux, F.; Engelmann, I.; Alidjinou, E. K.; Hober, D.; Brodin, P.; Beghyn, T.; Trottein, F.; Deprez, B.; Dubuisson, J.
10.1101/2021.06.30.450483 — microbiology — Posted on 2021-06-30
74 Pathology and immunity after SARS-CoV-2 infection in male ferrets is affected by age and inoculation route
van de Ven, K.; van Dijken, H.; Wijsman, L.; Gomersbach, A.; Schouten, T.; Kool, J.; Lenz, S.; Roholl, P.; Meijer, A.; van Kasteren, P.; de Jonge, J.
10.1101/2021.06.30.450298 — microbiology — Posted on 2021-06-30
75 Clonally expanded virus-specific CD8 T cells acquire diverse transcriptional phenotypes during acute, chronic, and latent infections
Kuhn, R.; Sandu, I.; Agrafiotis, A.; Hong, K.-L.; Neumeier, D.; Merkler, D.; Oxenius, A.; Reddy, S. T.; Yermanos, A.
10.1101/2021.06.29.450285 — immunology — Posted on 2021-06-30
76 Not all voxels are created equal: reducing estimation bias in regional NODDI metrics using tissue-weighted means
Parker, C. S.; Veale, T.; Bocchetta, M.; Slattery, C. F.; Malone, I. B.; Thomas, D. L.; Schott, J. M.; Cash, D. M.; Zhang, H.
10.1101/2021.06.29.450089 — neuroscience — Posted on 2021-06-30
78 A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer
Yang, C.; Chen, M.; Wang, S.; Qian, R.; Huang, X.; Wang, J.; Liu, Z.; Qin, W.-X.; Wang, C.; Hang, H.; Wang, H.
10.1101/2021.06.29.450305 — bioinformatics — Posted on 2021-06-30
79 Taming the massive genome of Scots pine with PiSy50k, a new genotyping array for conifer research
Kastally, C.; Niskanen, A. K.; Perry, A.; Kujala, S. T.; Avia, K.; Cervantes, S.; Haapanen, M.; Kesälahti, R.; Kumpula, T. A.; Mattila, T. M.; Ojeda, D. I.; Tyrmi, J. S.; Wachowiak, W.; Cavers, S.; Kärkkäinen, K.; Savolainen, O.; Pyhäjärvi, T.
10.1101/2021.06.29.450162 — genomics — Posted on 2021-06-30
80 SLOW5: a new file format enables massive acceleration of nanopore sequencing data analysis
Gamaarachchi, H.; Samarakoon, H.; Jenner, S. P.; Ferguson, J. M.; Amos, T. G.; Hammond, J. M.; Saadat, H.; Smith, M. A.; Parameswaran, S.; Deveson, I. W.
10.1101/2021.06.29.450255 — genomics — Posted on 2021-06-30
81 A quantitative trait variant in Gabra2 underlies increased methamphetamine stimulant sensitivity
Goldberg, L. R.; Yao, E. J.; Kelliher, J. C.; Reed, E. R.; Cox, J. W.; Parks, C.; Kirkpatrick, S. L.; Beierle, J. A.; Chen, M. M.; Johnson, W. E.; Homanics, G. E.; Williams, R. W.; Bryant, C. D.; Mulligan, M. K.
10.1101/2021.06.29.450337 — genetics — Posted on 2021-06-30
83 TACSTD2 upregulation is an early reaction to lung infection
Lenart, S.; Lenart, P.; Kotasova, H.; Pelkova, V.; Sedlakova, V.; Can, V.; Smarda, J.; Soucek, K.; Hampl, A.; Benes, P.
10.1101/2021.06.29.450320 — cell biology — Posted on 2021-06-30
84 The Consequences of Differential Origin Licensing Dynamics
Mei, L.; Kedziora, K. M.; Song, E.-a.; Purvis, J. E.; Cook, J. G.
10.1101/2021.06.28.450210 — molecular biology — Posted on 2021-06-30
86 Natural and after colon washing fecal samples: the two sides of the coin for investigating the human gut microbiome
Piancone, E.; Fosso, B.; De Robertis, M.; Notario, E.; Oranger, A.; Manzari, C.; Marzano, M.; Bruno, S.; D'Erchia, A. M.; Maio, D.; Minelli, M.; Vergallo, I.; Minelli, M.; Pesole, G.
10.1101/2021.06.29.450302 — molecular biology — Posted on 2021-06-30
87 IL-17+ mast cell/T helper cell axis in the early stages of acne
Eliasse, Y.; leveque, E.; Battut, L.; Nocera, T.; Garidou, L.; McKenzie, B.; Redoules, D.; Espinosa, E.
10.1101/2021.06.29.450328 — immunology — Posted on 2021-06-30
88 Quercetin ameliorates mitochondrial dysfunction and mitigates methamphetamine-induced anxiety-like behavior
Chen, F.; Sun, J.; Zhang, Y.; Dai, Y.; Zhang, Z.; Chen, C.; Zou, L.; Wu, H.; Tian, W.; Xu, Y.; Luo, H.; Yu, J.; Wang, K.
10.1101/2021.06.29.450268 — neuroscience — Posted on 2021-06-30
99 HMMploidy: inference of ploidy levels from short-read sequencing data
Soraggi, S.; Rhodes, J.; Altinkaya, I.; Tarrant, O.; Balloux, F.; Fisher, M. C.; Fumagalli, M.
10.1101/2021.06.29.450340 — bioinformatics — Posted on 2021-06-30
100 Validation of Data Acquisition and Phase Estimation for Quantitative Susceptibility Mapping with a Rotating-Tube Phantom
Keenan, K. E.; Berman, B. P.; Carnicka, S.; Russek, S. E.; Wang, W.-T.; Butman, J. A.; Pham, D. L.; Dagher, J.
10.1101/2021.06.29.450224 — bioengineering — Posted on 2021-06-30
103 Meta-analysis shows both congruence and complementarity of DNA metabarcoding to traditional methods for biological community assessment
Keck, F.; Blackman, R. C.; Bossart, R.; Brantschen, J.; Couton, M.; Hürlemann, S.; Kirschner, D.; Locher, N.; Zhang, H.; Altermatt, F.
10.1101/2021.06.29.450286 — ecology — Posted on 2021-06-30
105 Highly-Neutralizing COVID-19-Convalescent-Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters.
Takamatsu, Y.; Imai, M.; Maeda, K.; Nakajima, N.; Higashi-Kuwata, N.; Iwatsuki-Horimoto, K.; Ito, M.; Kiso, M.; Maemura, T.; Takeda, Y.; Omata, K.; Suzuki, T.; Kawaoka, Y.; Mitsuya, H.
10.1101/2021.06.29.450453 — microbiology — Posted on 2021-06-30
108 Using diffusion MRI data acquired with ultra-high gradients to improve tractography in routine-quality data
Maffei, C.; Lee, C.; Planich, M.; Ramprasad, M.; Ravi, N.; Trainor, D.; Urban, Z.; Kim, M.; Jones, R.; Henin, A.; Hofmann, S.; Pizzagalli, D.; Auerbach, R.; Gabrieli, J.; Whitfield-Gabrieli, S.; Greve, D.; Haber, S.; Yendiki, A.
10.1101/2021.06.28.450265 — neuroscience — Posted on 2021-06-30
112 Comprehensive analysis of full-length transcripts reveal aberrations of splicing variants in liver cancer
Kiyose, H.; Nakagawa, H.; Ono, A.; Aikata, H.; Ueno, M.; Hayami, S.; Yamaue, H.; Chayama, K.; Shimada, M.; Wong, J. H.; Fujimoto, A.
10.1101/2021.06.28.450266 — cancer biology — Posted on 2021-06-30
117 ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 1 disease
Fischer, R.; van Doremalen, N.; Adney, D.; Yinda, C.; Port, J.; Holbrook, M.; Schulz, J.; Williamson, B.; Thomas, T.; Barbian, K.; Anzick, S.; Ricklefs, S.; Smith, B.; Long, D.; Martens, C.; Saturday, G.; de Wit, E.; Gilbert, S.; Lambe, T.; Munster, V.
10.1101/2021.03.11.435000 — microbiology — Posted on 2021-06-30
118 Nafamostat-interferon-alpha combination suppresses SARS-CoV-2 infection by targeting cooperatively host TMPRSS2 in vitro and in vivo
Ianevski, A.; Yo, R.; Lysvand, H.; Grodeland, G.; Legrand, N.; Oksenych, V.; Zusinaite, E.; Tenson, T.; Bjoras, M.; Kainov, D. E.
10.1101/2021.06.16.448653 — microbiology — Posted on 2021-06-30
119 Efficient discovery of potently neutralizing SARS-CoV-2 antibodies using LIBRA-seq with ligand blocking
Shiakolas, A. R.; Johnson, N.; Kramer, K. J.; Suryadevara, N.; Wrapp, D.; Periasamy, S.; Pilewski, K. A.; Raju, N.; Nargi, R.; Sutton, R. E.; Walker, L.; Setliff, I.; Crowe, J. E.; Bukreyev, A.; Carnahan, R. H.; McLellan, J. S.; Georgiev, I. S.
10.1101/2021.06.02.446813 — immunology — Posted on 2021-06-30
121 Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging
Wang, C.; Martins-Bach, A. B.; Alfaro-Almagro, F.; Douaud, G.; Klein, J. C.; Llera, A.; Fiscone, C.; Bowtell, R.; Elliott, L. T.; Smith, S. M.; Tendler, B. C.; Miller, K. L.
10.1101/2021.06.28.450248 — neuroscience — Posted on 2021-06-30
122 Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome
Zeng, Y.; Amador, C.; Gao, C.; Walker, R. M.; Morris, S. W.; Campbell, A.; Frkatovi_, A.; Madden, R. A.; Adams, M. J.; He, S.; Bretherick, A. D.; Hayward, C.; Porteous, D. J.; Wilson, J. F.; Evans, K. L.; Mcintosh, A. M.; Navarro, P.; Haley, C. S.
10.1101/2021.06.28.450122 — genetics — Posted on 2021-06-30
123 The NUCKS1-SKP2-p21/p27 axis controls S phase entry
Hume, S.; Grou, C. P.; Lascaux, P.; D'Angiolella, V.; Legrand, A. J.; Ramadan, K.; Dianov, G. L.
10.1101/2021.06.29.450420 — cancer biology — Posted on 2021-06-30
128 Pre-Implantation Alcohol Exposure Induces Lasting Sex-Specific DNA Methylation Programming Errors in the Developing Forebrain
Legault, L.-M.; Doiron, K.; Breton-Larrivee, M.; Langford-Avelar, A.; Lemieux, A.; Caron, M.; Jerome-Majewska, L. A.; Sinnett, D.; McGraw, S.
10.1101/2020.12.07.415208 — developmental biology — Posted on 2021-06-30
129 Nef enhances HIV-1 replication and infectivity independently of SERINC3 and SERINC5 in CEM T cells
Ramirez, P. W.; Angerstein, A. A.; Suarez, M.; Vollbrecht, T.; Wallace, J.; O'Connell, R. M.; Guatelli, J.
10.1101/2020.07.15.205757 — microbiology — Posted on 2021-06-30
131 Structure-aware M. tuberculosis functional annotation uncloaks resistance, metabolic, and virulence genes
Modlin, S. J.; Elghraoui, A.; Gunasekaran, D.; Zlotnicki, A. M.; Dillon, N. A.; Dhillon, N.; Kuo, N.; Robinhold, C.; Chan, C. K.; Baughn, A. D.; Valafar, F.
10.1101/358986 — genomics — Posted on 2021-06-30
132 The MuvB Complex Binds and Stabilizes Nucleosomes Downstream of the Transcription Start Site of Cell-Cycle Dependent Genes
Asthana, A.; Ramanan, P.; Hirschi, A.; Guiley, K. Z.; Wijeratne, T. U.; Shelansky, R.; Doody, M. J.; Narasimhan, H.; Boeger, H.; Tripathi, S.; Mueller, G. A.; Rubin, S. M.
10.1101/2021.06.29.450381 — molecular biology — Posted on 2021-06-30
133 Synthesis and characterization of 5-(2-fluoro-4-pyridine-7-carboxamide as a PET imaging ligand for metabotropic glutamate receptor 2
Yuan, G.; Dhaynaut, M.; Lan, Y.; Guehl, N. J.; Huynh, D.; Iyengar, S.; Afshar, S.; Wang, H.; Moon, S.-H.; Ondrechen, M. J.; Wang, C.; Shoup, T.; El Fakhri, G.; Normandin, M. D.; Brownell, A.-L.
10.1101/2021.06.29.450413 — neuroscience — Posted on 2021-06-30
135 The P-selectin ligand PSGL-1 (CD162) is efficiently incorporated by primary HIV-1 isolates and can facilitate trans-infection
Burnie, J.; Persaud, A. T.; Thaya, L.; Liu, Q.; Miao, H.; Grabinsky, S.; Norouzi, V.; Lusso, P.; Tang, V. A.; Guzzo, C.
10.1101/2021.06.29.450454 — microbiology — Posted on 2021-06-30
137 Deciphering the landscape of phosphorylated HLA-II ligands
Solleder, M.; Racle, J.; Guillaume, P.; Coukos, G.; Bassani-Sternberg, M.; Gfeller, D.
10.1101/2021.06.29.450288 — immunology — Posted on 2021-06-30
140 Cystinosin deficient rats recapitulate the phenotype of nephropathic cystinosis
Hollywood, J. A.; Kallingappa, P. K.; Cheung, P. Y.; Martis, R. M.; Sreebhavan, S.; Chatterjee, A.; Buckels, E. J.; Matthews, B. G.; Lewis, P. M.; Davidson, A. J.
10.1101/2021.06.29.450444 — physiology — Posted on 2021-06-30
142 Functional control of a 0.5 MDa TET aminopeptidase by a flexible loop revealed by MAS NMR
Gauto, D. F.; Macek, P.; Malinverni, D.; Fraga, H.; Paloni, M.; Hessel, A.; Bustamante, J. P.; Barducci, A.; Schanda, P.
10.1101/2021.06.29.450317 — biophysics — Posted on 2021-06-30
143 The ACF Chromatin Remodeling Complex is Essential for Polycomb Repression
Selker, E. U.; Wiles, E. T.; Mumford, C. C.; McNaught, K. J.; Tanizawa, H.
10.1101/2021.06.29.450346 — genetics — Posted on 2021-06-30
144 CENP-N promotes the compaction of centromeric chromatin
Zhou, K.; Gebala, M.; Woods, D. C.; Sundararajan, K.; Edwards, G.; Krzizike, D.; Wereszczynski, J.; Straight, A. F.; Luger, K.
10.1101/2021.06.14.448351 — molecular biology — Posted on 2021-06-30
145 Waffle Method: A general and flexible approach for FIB-milling small and anisotropically oriented samples
Kelley, K.; Raczkowski, A. M.; Klykov, O.; Jaroenlak, P.; Bobe, D.; Kopylov, M.; Eng, E. T.; Bhabha, G.; Potter, C. S.; Carragher, B.; Noble, A. J.
10.1101/2020.10.28.359372 — microbiology — Posted on 2021-06-30
149 The myopathic transcription factor DUX4 induces the production of truncated RNA-bindingproteins in human muscle cells
Campbell, A. E.; Dyle, M. C.; Calviello, L.; Matheny, T.; Cortazar, M. A.; Forman, T.; Fu, R.; Gillen, A. E.; Floor, S. N.; Jagannathan, S.
10.1101/2021.06.28.450189 — genomics — Posted on 2021-06-30
150 Epigenetic Regulation of Nuclear Lamina-Associated Heterochromatin by HAT1 and the Acetylation of Newly Synthesized Histones
Popova, L. V.; Nagarajan, P.; Lovejoy, C. M.; Sunkel, B. D.; Gardner, M. L.; Wang, M.; Freitas, M. A.; Stanton, B.; Parthun, M. R.
10.1101/2021.06.28.450212 — genomics — Posted on 2021-06-30
151 Pleiotropy is associated with fitness consequences of new mutations in mutation accumulation lines
Kreutzmann, S.; Pompa, E.; Nguyen, N.; Tilahun, L.; Rutter, M. T.; Weng, M.-L.; Fenster, C. B.; Olson-Manning, C. F.
10.1101/2021.06.28.450192 — evolutionary biology — Posted on 2021-06-30
152 Whole genome sequencing elucidates the species-wide diversity and evolution of fungicide resistance in the early blight pathogen Alternaria solani
Einspanier, S.; Susanto, T.; Metz, N.; Wolters, P. J.; Vleeshouwers, V. G. A. A.; Lankinen, A.; Liljeroth, E.; Landschoot, S.; Ivanovic, Z.; Hückelhoven, R.; Hausladen, H.; Stam, R.
10.1101/2021.06.28.450143 — evolutionary biology — Posted on 2021-06-30
154 Truncated denitrifiers dominate the denitrification pathway in tundra soil metagenomes
Pessi, I. S.; Viitamaki, S.; Virkkala, A.-M.; Eronen-Rasimus, E.; Delmont, T. O.; Marushchak, M. E.; Luoto, M.; Hultman, J.
10.1101/2020.12.21.419267 — microbiology — Posted on 2021-06-30
155 THERAPEUTIC EFFECTS OF HYPOXIC AND PRO-INFLAMMATORY PRIMING OF MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES IN INFLAMMATORY ARTHRITIS
Kay, A. G.; Treadwell, K.; Roach, P.; Morgan, R.; Lodge, R.; Hyland, M.; Piccinini, A.; Forsyth, N. R.; Kehoe, O.
10.1101/2021.06.28.450178 — immunology — Posted on 2021-06-30
156 Structural analysis of the C. elegans dauer larval anterior sensilla by Focused Ion Beam-Scanning Electron Microscopy
Britz, S.; Markert, S. M.; Witvliet, D.; Steyer, A. M.; Troeger, S.; Mulcahy, B.; Kollmannsberger, P.; Schwab, Y.; Zhen, M.; Stigloher, C.
10.1101/2021.06.29.449894 — neuroscience — Posted on 2021-06-30
157 Brain histone beta-hydroxy-butyrylation couples metabolism with gene expression
Cornuti, S.; Lupori, L.; Chen, S.; Finamore, F.; Samad, M.; Raimondi, F.; Mazziotti, R.; Magnan, C.; Rocchiccioli, S.; Baldi, P.; Tognini, P.; Pizzorusso, T.
10.1101/2021.06.28.449924 — neuroscience — Posted on 2021-06-30
158 Brain signaling dynamics after vagus nerve stimulation
Teckentrup, V.; Krylova, M.; Jamalabadi, H.; Neubert, S.; Neuser, M. P.; Hartig, R.; Fallgatter, A. J.; Walter, M.; Kroemer, N. B.
10.1101/2021.06.28.450171 — neuroscience — Posted on 2021-06-30
159 Interrogation of genome-wide, experimentally dissected gene regulatory networks reveals mechanisms underlying dynamic cellular state control
Tan, X.; Worley, J.; Turunen, M.; Wong, K.; Fernandez, E. C.; Paull, E.; Jones, S.; Wang, J.; Noh, H.; Salvatori, B.; Chavez, A.; Califano, A.
10.1101/2021.06.28.449297 — systems biology — Posted on 2021-06-30
160 Human engineered heart tissue transplantation in a guinea pig chronic injury model
von Bibra, C.; Shibamiya, A.; Geertz, B.; Querdel, E.; Koehne, M.; Stuedemann, T.; Starbatty, J.; Hansen, A.; Hiebl, B.; Eschenhagen, T.; Weinberger, F.
10.1101/2021.06.28.450176 — pharmacology and toxicology — Posted on 2021-06-30
162 Spatial epitope barcoding reveals subclonaltumor patch behaviors
Rovira-Clave, X.; Drainas, A. P.; Jiang, S.; Bai, Y.; Baron, M.; Zhu, B.; Markovic, M.; Coles, G. L.; Bassik, M. C.; Sage, J.; Nolan, G. P.
10.1101/2021.06.29.449991 — cancer biology — Posted on 2021-06-30
163 Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients
Nguyen, B.; Fong, C.; Luthra, A.; Smith, S. A.; DiNatale, R. G.; Nandakumar, S.; Walch, H.; Chatila, W. K.; Madupuri, R.; Kundra, R.; Bielski, C. M.; Mastrogiacomo, B.; Boire, A.; Chandarlapaty, S.; Ganesh, K.; Harding, J. J.; Iacobuzio-Donahue, C. A.; Razavi, P.; Reznik, E.; Rudin, C. M.; Zamarin, D.; Abida, W.; Abou-Alfa, G. K.; Aghajanian, C.; Cercek, A.; Chi, P.; Feldman, D.; Ho, A. L.; Iyer, G.; Janjigian, Y. Y.; Morris, M.; Motzer, R. J.; O'Reilly, E. M.; Postow, M. A.; Raj, N. P.; Riely, G. J.; Robson, M. E.; Rosenberg, J. E.; Safonov, A.; Shoushtari, A. N.; Tap, W.; Teo, M. Y.; Varghes
10.1101/2021.06.28.450217 — cancer biology — Posted on 2021-06-30
166 Raloxifene reduces sex- and age-related intervertebral disc degeneration in mice by estrogen signaling
Bhadouria, N.; Niziolek, P.; El Jordi, O.; Berman, A. G.; McKinzie, D.; Wallace, J. M.; Holguin, N.
10.1101/2021.06.29.449482 — bioengineering — Posted on 2021-06-30
167 Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Pancreatic Islets
Zhu, J.; He, Y.; Kong, L.; He, Z.; Kang, K.; Grady, S.; Nguyen, L.; Chen, D.; Wang, Y.; Oberholzer, J.; Cai, L.
10.1101/2021.06.29.449587 — bioengineering — Posted on 2021-06-30
172 One gene - two proteins: The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria
Petragnano, F.; Fasciani, I.; Wang, Z.; Edwards, R.; Telugu, N.; Pietrantoni, I.; Zauber, H.; Rossi, M.; Zabel, U.; Grieben, M.; Terzenidou, M. E.; Di Gregorio, J.; Pellegrini, C.; Santini, S.; Taddei, A. R.; Poehl, B.; Aringhieri, S.; Aloisi, G.; Marampon, F.; Roman, A.; Diecke, S.; Flati, V.; Giorgi, F.; Tobin, A. B.; Scarselli, M.; Tokatlidis, K.; Amicarelli, F.; Lohse, M. J.; Maggio, R.; Annibale, P.
10.1101/2021.04.13.438299 — cell biology — Posted on 2021-06-30
174 The Mycobacterium tuberculosis sRNA F6 modifies expression of essential chaperonins, GroEL2 and GroES
Houghton, J.; Rodgers, A.; Rose, G.; D'Halluin, A.; Kipkorir, T.; Barker, D.; Waddell, S.; Arnvig, K. B.
10.1101/2020.07.15.204107 — microbiology — Posted on 2021-06-30
177 Ureides are similarly accumulated in response to UV-C irradiation and wound but differently remobilized during recovery in Arabidopsis leaves.
Soltabayeva, A.; Bekturova, A.; Kurmanbayeva, A.; Oshanova, D.; Nurbekova, Z.; Srivastava, S.; Standing, D.; Sagi, M.
10.1101/2021.06.29.450374 — plant biology — Posted on 2021-06-30
178 Molecular characterization reveals genomic and transcriptomic subtypes of metastatic urothelial carcinoma
Nakauma-Gonzalez, J. A.; Rijnders, M.; van Riet, J.; van der Heijden, M. S.; Voortman, J.; Cuppen, E. P. J. G.; Mehra, N.; van Wilpe, S.; Oosting, S. F.; Rijstenberg, L. L.; Westgeest, H. M.; Zwarthoff, E.; de Wit, R.; van der Veldt, A. A. M.; van de Werken, H. J. G.; Lolkema, M. P. J.; Boormans, J. L.
10.1101/2021.03.17.435757 — cancer biology — Posted on 2021-06-30
181 The genome of the CTG(Ser1) yeast Scheffersomyces stipitis is plastic
Vega Estevez, S.; Armitage, A.; Bates, H. J.; Harrison, R. J.; Buscaino, A.
10.1101/2021.02.15.431239 — genomics — Posted on 2021-06-30
190 Unbiased in vivo exploration of nuclear bodies-enhanced sumoylation reveals that PML orchestrates embryonic stem cell fate
Tessier, S.; Ferhi, O.; Geoffroy, M.-C.; Gonzalez-Prieto, R.; Canat, A.; Quentin, S.; Pla, M.; Niwa-Kawakita, M.; Bercier, P.; Rerolle, D.; Therizols, P.; Fabre, E.; Vertegaal, A. C. O.; de The, H.; Lallemand-Breitenbach, V.
10.1101/2021.06.29.450368 — cell biology — Posted on 2021-06-29
191 Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells
Missinato, M. A.; Murphy, S. A.; Lynott, M.; Kervadec, A.; Yu, M. S.; Chang, Y.-L.; Kannan, S.; Loreti, M.; Lee, C.; Amatya, P.; Tanaka, H.; Huang, C.-T.; Puri, P. L.; Kwon, C.; Adams, P. D.; Qian, L.; Sacco, A.; Andersen, P.; Colas, A. R.
10.1101/2021.06.28.450261 — cell biology — Posted on 2021-06-29
192 Actin force generation in vesicle formation: mechanistic insights from cryo-electron tomography
Serwas, D.; Akamatsu, M.; Moayed, A.; Vegesna, K.; Vasan, R.; Hill, J. M.; Schoeneberg, J.; Davies, K. M.; Rangamani, P.; Drubin, D. G.
10.1101/2021.06.28.450262 — cell biology — Posted on 2021-06-29
193 Oncofetal protein CRIPTO regulates wound healing and fibrogenesis in regenerating liver and is associated with the initial stages of cardiac fibrosis
Karkampouna, S.; van der Helm, D.; van Hoek, B.; Verspaget, H. W.; Goumans, M. J. T.; Coenraad, M.; Kruithof, B. T.; Kruithof-deJulio, M.
10.1101/2021.06.29.450195 — cell biology — Posted on 2021-06-29
196 A centronuclear myopathy-causing mutation in dynamin-2 perturbs the actin-dependent structure of dendritic spines leading to excitatory synaptic defects in a murine model of the disease
ARRIAGADA-DIAZ, J.; Gomez, B.; Prado-Vega, L.; MATTAR-ARAOS, M.; LABRANA-ALLENDE, M.; HINOSTROZA, F.; Gajardo, I.; Guerra-Fernandez, M. J.; Bevilacqua, J. A.; CARDENAS, A. M.; Bitoun, M.; ARDILES, A. O.; GONZALEZ-JAMETT, A. M.
10.1101/2021.06.28.450172 — neuroscience — Posted on 2021-06-29
199 HPLC Method to Resolve, Identify and Quantify Guanine Nucleotides Bound to the GTPase Ras
Hannan, J. P.; Swisher, G. H.; Martyr, J. G.; Cordaro, N. J.; Erbse, A. H.; Falke, J. J.
10.1101/2021.06.28.450218 — cancer biology — Posted on 2021-06-29
200 GLI transcriptional repression is inert prior to Hedgehog pathway activation
Lex, R. K.; Zhou, W.; Ji, Z.; Falkenstein, K. N.; Schuler, K. E.; Windsor, K. E.; Kim, J. D.; Ji, H.; Vokes, S. A.
10.1101/2021.06.29.450392 — developmental biology — Posted on 2021-06-29
202 NON-LINEAR SUSCEPTIBILITY TO INTERFERENCES IN DECLARATIVE MEMORY FORMATION
Moyano, M. D.; Carbonari, G.; Bonilla, M.; Pedreira, M. E.; Brusco, L. I.; Kaczer, L.; Forcato, C.
10.1101/2021.06.29.450433 — neuroscience — Posted on 2021-06-29
206 Prediction of the sex-determination gene in tunas (Thunnus fishes)
Nakamura, Y.; Higuchi, K.; Kumon, K.; Yasuike, M.; Takashi, T.; Gen, K.; Fujiwara, A.
10.1101/2021.06.15.448492 — genomics — Posted on 2021-06-29
211 pre-mRNA spatial distributions suggest that splicing can occur post-transcriptionally
Cote, A. J.; Cote, C. J.; Bayatpour, S.; Drexler, H. L.; Alexander, K. A.; Chen, F.; Wassie, A. T.; Boyden, E. S.; Berger, S.; Churchman, L. S.; Raj, A.
10.1101/2020.04.06.028092 — cell biology — Posted on 2021-06-29
213 Waffle Method: A general and flexible approach for FIB-milling small and anisotropically oriented samples
Kelley, K.; Klykov, O.; Raczkowski, A. M.; Jaroenlak, P.; Bobe, D.; Kopylov, M.; Eng, E. T.; Bhabha, G.; Potter, C. S.; Carragher, B.; Noble, A. J.
10.1101/2020.10.28.359372 — microbiology — Posted on 2021-06-29
215 The NUCKS1-SKP2-p21/p27 axis controls S phase entry
Hume, S.; Grou, C. P.; Lascaux, P.; D'Angiolella, V.; Legrand, A. J.; Ramadan, K.; Dianov, G. L.
10.1101/2021.06.29.450420 — cancer biology — Posted on 2021-06-29
221 Median based absolute quantification of proteins using Fully Unlabelled Generic Internal Standard
Raghuraman, B. K.; Bogdanova, A.; Moon, H.; Rzagalinski, I.; Geertsma, E.; Hersemann, L.; Shevchenko, A.
10.1101/2021.06.28.450203 — biochemistry — Posted on 2021-06-29
222 AUTS2 controls neuronal lineage choice through a novel PRC1-independent complex and BMP inhibition
Geng, Z.; Wang, Q.; Miao, W.; Wolf, T.; Chavez, J.; Giddings, E.; Hobbs, R.; DeGraff, D. J.; Wang, Y.; Stafford, J.; Gao, Z.
10.1101/2021.06.29.450402 — biochemistry — Posted on 2021-06-29
226 Systems Genetics of Single Nucleotide Polymorphisms at the Drosophila Obp56h Locus
Mokashi, S. S.; Shankar, V.; Johnstun, J. A.; Huang, W.; Mackay, T. F. C.; Anholt, R. R. H.
10.1101/2021.06.28.450219 — genetics — Posted on 2021-06-29
228 A genomic assessment of the marine-speciation paradox within the toothed whale superfamily Delphinoidea
Westbury, M. V.; Cabrera, A. A.; Rey-Iglesia, A.; De Cahsan, B.; Duchene, D. A.; Hartmann, S.; Lorenzen, E. D.
10.1101/2020.10.23.352286 — evolutionary biology — Posted on 2021-06-29
240 Engineered receptor binding domain immunogens elicit pan-sarbecovirus neutralizing antibodies
Hauser, B. M.; Sangesland, M.; Lam, E. C.; St. Denis, K. J.; Feldman, J.; Yousif, A. S.; Caradonna, T. M.; Kannegieter, T.; Balazs, A. B.; Lingwood, D.; Schmidt, A. G.
10.1101/2020.12.07.415216 — immunology — Posted on 2021-06-29
241 Impact of early childhood malnutrition on the adult brain function: an ERP study
Roger, K.; Vannasing, P.; Tremblay, J.; Bringas Vega, M. L.; Bryce, C. P.; Rabinowitz, A. G.; Valdes-Sosa, P. A.; Galler, J. R.; Gallagher, A.
10.1101/782698 — neuroscience — Posted on 2021-06-29
243 Perceived and mentally rotated contents are differentially represented in cortical depth of V1
Iamshchinina, P.; Kaiser, D.; Yakupov, R.; Haenelt, D.; Sciarra, A.; Mattern, H.; Luesebrink, F.; Duezel, E.; Speck, O.; Weiskopf, N.; Cichy, R. M.
10.1101/2021.04.27.440989 — neuroscience — Posted on 2021-06-29
245 A chromosome-level genome sequence of a model chrysanthemum: evolution and 1 reference for hexaploid cultivated chrysanthemum
Nakano, M.; Hirakawa, H.; Fukai, E.; Toyoda, A.; Kajitani, R.; Minakuchi, Y.; Itoh, T.; Higuchi, Y.; Kozuka, T.; Bono, H.; Shirasawa, K.; Shiraiwa, I.; Sumitomo, K.; Hisamatsu, T.; Shibata, M.; Isobe, S.; Taniguchi, K.; Kusaba, M.
10.1101/2021.06.28.450068 — plant biology — Posted on 2021-06-29
248 Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration
Nicolai, L.; Leunig, A.; Pekayvaz, K.; Anjum, A.; Riedlinger, E.; Eivers, L.; Hoffknecht, M.-L.; Rossaro, D.; Escaig, R.; Kaiser, R.; Polewka, V.; Titova, A.; Spiekermann, K.; Iannacone, M.; Stark, K.; Massberg, S.
10.1101/2021.06.29.450356 — immunology — Posted on 2021-06-29
249 Genetic diversity and evolution of SARS-CoV-2 in Belgium during the first wave outbreak
Wawina-Bokalanga, T.; Marti-Carreras, J.; Vanmechelen, B.; Bloemen, M.; Wollants, E.; Laenen, L.; Cuypers, L.; Beuselinck, K.; Lagrou, K.; Andre, E.; Van Ranst, M.; Maes, P.
10.1101/2021.06.29.450330 — genomics — Posted on 2021-06-29
250 Absolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences
Lee, J. Y.; Wing, P. A.; Gala, D. S.; Jarvelin, A. I.; Titlow, J.; Noerenberg, M.; Zhuang, X.; Johnson, N.; Iselin, L.; Thompson, M. K.; Parton, R. M.; Wainman, A.; Agranoff, D.; James, W.; Castello, A.; McKeating, J. A.; Davis, I.
10.1101/2021.06.29.450133 — microbiology — Posted on 2021-06-29
252 Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain
Cerutti, G.; Guo, Y.; Wang, P.; Nair, M. S.; Huang, Y.; Yu, J.; Liu, L.; Katsamba, P. S.; Bahna, F.; Reddem, E. R.; Kwong, P. D.; Ho, D. D.; Sheng, Z.; Shapiro, L.
10.1101/2021.06.29.450397 — immunology — Posted on 2021-06-29
253 Rapid determination of the wide dynamic range of SARS-CoV-2 Spike T cell responses in whole blood of vaccinated and naturally infected
Tan, A. T.; Lim, J. M.; Le Bert, N.; Kunasegaran, K.; Chia, A.; Qui, M.; Tan, N.; Chia, W. N.; Alwis, R.; Ding, Y.; Ooi, E. E.; Wang, L.-F.; Chen, M. I.; Young, B.; Hsu, L. Y.; Low, J.; Lye, D.; Bertoletti, A.
10.1101/2021.06.29.450293 — immunology — Posted on 2021-06-29
254 Systematic genome-scale identification of host factors for SARS-CoV-2 infection across models yields a core single gene dependency; ACE2
Chan, K.; Farias, A. G.; Lee, H.; Guvenc, F.; Mero, P.; Aulakh, K.; Brown, K. R.; Haider, S.; Marcon, E.; Braunschweig, U.; Tong, A. H. Y.; Pu, S.; Habsid, A.; Christie-Holmes, N.; Budylowski, P.; Astori, A.; Ghalami, A.; Mubareka, S.; Banerjee, A.; Mossman, K. L.; Greenblatt, J.; Gray-Owen, S. D.; Raught, B.; Blencowe, B.; Taiplale, M.; Moffat, J.
10.1101/2021.06.28.450244 — systems biology — Posted on 2021-06-29
256 Ureides are similarly accumulated in response to UV-C irradiation and wound but differently remobilized during recovery in Arabidopsis leaves.
Soltabayeva, A.; Bekturova, A.; Kurmanbayeva, A.; Oshanova, D.; Nurbekova, Z.; Srivastava, S.; Standing, D.; Sagi, M.
10.1101/2021.06.29.450374 — plant biology — Posted on 2021-06-29
260 Hippocampal neurons code individual memory episodes in humans
Kolibius, L. D.; Roux, F.; Parish, G. M.; ter Wal, M. J.; Van Der Plas, M.; Chelvarajah, R.; Sawlani, V.; Rollings, D.; Lang, J.; Gollwitzer, S.; Hopfengaertner, R.; Kreiselmeyer, G.; Hamer, H.; Staresina, B. P.; Wimber, M.; Bowman, H.; Hanslmayr, S.
10.1101/2021.06.28.450149 — neuroscience — Posted on 2021-06-29
261 Innate, translation-dependent silencing of an invasive transposon in Arabidopsis
Oberlin, S.; Rajeswaran, R.; Trasser, M.; Barragan-Borrero, V.; Schon, M. A.; Plotnikova, A.; Loncsek, L.; Nodine, M. D.; Mari-Ordonez, A.; Voinnet, O.
10.1101/2021.06.29.450179 — plant biology — Posted on 2021-06-29
263 Transfer learning improves outcome predictions for ASD from gene expression in blood
Robasky, K.; Kim, R.; Yi, H.; Xu, H.; Bao, B.; Chang, A. W. T.; Courchesne, E.; Lewis, N. E.
10.1101/2021.06.26.449864 — bioinformatics — Posted on 2021-06-29
265 Enhanced FcγRIII/CD16 activation by discrete ligands as independent correlates of disease severity in COVID-19 patients
Ankerhold, J.; Giese, S.; Kolb, P.; Maul-Pavicic, A.; Goeppert, N.; Ciminski, K.; Kreutz, C.; Lother, A.; Salzer, U.; Bildl, W.; Welsink, T.; Morgenthaler, N.; Busse Grawitz, A.; Huzly, D.; Schwemmle, M.; Hengel, H.; Falcone, V.
10.1101/2021.06.25.449893 — immunology — Posted on 2021-06-29
269 The RAG1 Ubiquitin Ligase Domain Enhances Assembly and Selection of T Cell Receptor Genes to Restrain the Autoimmune Hazard of Generating T Cell Receptor Diversity
Burn, T.; Miot, C.; Gordon, S.; Culberson, E.; Diamond, T.; Kreiger, P.; Hayer, K.; Bhattacharyya, A.; Jones, J.; Bassing, C.; Behrens, E.
10.1101/2021.01.04.425211 — immunology — Posted on 2021-06-29
273 Deep-learning based identification, pose estimation and end-to-end behavior classification for interacting primates and mice in complex environments
Marks, M.; Qiuhan, J.; Sturman, O.; von Ziegler, L.; Kollmorgen, S.; von der Behrens, W.; Mante, V.; Bohacek, J.; Yanik, M. F.
10.1101/2020.10.26.355115 — neuroscience — Posted on 2021-06-29
274 Multimodal multilayer network centrality relates to executive functioning
Breedt, L. C.; Santos, F. A. N.; Hillebrand, A.; Reneman, L.; van Rootselaar, A.-F.; Schoonheim, M. M.; Stam, C. J.; Ticheler, A.; Tijms, B.; Veltman, D. J.; Vriend, C.; Wagenmakers, M. J.; van Wingen, G. A.; Geurts, J. J. G.; Schrantee, A.; Douw, L.
10.1101/2021.06.28.450180 — neuroscience — Posted on 2021-06-29
276 OpenNeuro: An open resource for sharing of neuroimaging data
Markiewicz, C. J.; Gorgolewski, K. J.; Feingold, F.; Blair, R.; Halchenko, Y. O.; Miller, E.; Hardcastle, N.; Wexler, J.; Esteban, O.; Goncalves, M.; Jwa, A. S.; Poldrack, R.
10.1101/2021.06.28.450168 — neuroscience — Posted on 2021-06-29
279 ASER: Animal Sex Reversal database
Li, Y.; Chen, Z.; Liu, H.; Li, Q.; Lin, X.; Ji, S.; Li, R.; Li, S.; Fan, W.; Zhao, H.; Zhu, Z.; Hu, W.; Zhou, Y.; Luo, D.
10.1101/2021.06.28.448629 — zoology — Posted on 2021-06-29
285 Identification of sample mix-ups and mixtures in microbiome data in Diversity Outbred mice
Lobo, A. K.; Traeger, L. L.; Keller, M. P.; Attie, A. D.; Rey, F. E.; Broman, K. W.
10.1101/529040 — genetics — Posted on 2021-06-29
286 The 55K SNP-Based Exploration of QTL for Spikelet Number Per Spike in a Tetraploid Wheat (Triticum turgidum L.) Population: Chinese Landrace Ailanmai X Wild Emmer
Mo, Z.; Zhu, J.; Wei, J.; Zhou, J.; Xu, Q.; Tang, H.; Mu, Y.; Deng, M.; Jiang, Q.; Liu, Y.; Chen, G.; Wang, J.; Qi, P.; Li, W.; Wei, Y.; Zheng, Y.; Lan, X.; Ma, J.
10.1101/2020.10.21.348227 — genetics — Posted on 2021-06-29
288 Predicting the zoonotic capacity of mammals to transmit SARS-CoV-2
Fischhoff, I. R.; Castellanos, A. A.; Rodrigues, J. P. G. L. M.; Varsani, A.; Han, B. A.
10.1101/2021.02.18.431844 — ecology — Posted on 2021-06-29
289 Climate risk to European fisheries and coastal communities
Payne, M. R.; Kudahl, M.; Engelhard, G. H.; Peck, M. A.; Pinnegar, J. K.
10.1101/2020.08.03.234401 — ecology — Posted on 2021-06-29
290 Insulin mRNA is stored in RNA granules in resting beta cells
Vasiljevic, J.; Vasiljevic, D.; Ganss, K.; Sönmez, A.; Wegbrod, C.; Quezada, E.; Münster, C.; Schöniger, E.; Friedland, D.; Kipke, N.; Distler, M.; Selbach, M.; Solimena, M.
10.1101/2021.05.07.443159 — cell biology — Posted on 2021-06-29
292 Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2
Sun, S.; Gu, H.; Cao, L.; Chen, Q.; Ye, Q.; Yang, G.; Li, R.-T.; Fan, H.; Deng, Y.-Q.; Song, X.; Qi, Y.; Li, M.; Lan, J.; Feng, R.; Yan, G.; Zhu, N.; Qin, S.; Wang, L.; Zhang, Y.; Zhou, C.; Zhao, L.; Chen, Y.; Shen, M.; Cui, Y.; Yang, X.; Wang, X.; Tan, W.; Wang, H.; Wang, X.; Qin, C.
10.1101/2020.11.10.377333 — microbiology — Posted on 2021-06-29
293 Genomic insights into the Archaea inhabiting an Australian radioactive legacy site
Vazquez-Campos, X.; Kinsela, A. S.; Bligh, M. W.; Payne, T. E.; Wilkins, M. R.; Waite, T. D.
10.1101/728089 — microbiology — Posted on 2021-06-29
297 TRPA1 block protects against loss of white matter function during ischaemia in the mouse optic nerve
Lajoso, W.; Flower, G.; Giacco, V.; La Mache, C.; Braban, A.; Roxas, A.; Hamilton-Whitaker, N. B.
10.1101/2021.05.25.445536 — neuroscience — Posted on 2021-06-29
302 Measuring arterial pulsatility with Dynamic Inflow MAgnitude Contrast (DIMAC)
Whittaker, J. R.; Fasano, F.; Venzi, M.; Liebig, P.; Gallichan, D.; Murphy, K.
10.1101/2021.01.08.425882 — bioengineering — Posted on 2021-06-29
305 Exploration and analysis of molecularly annotated, 3D models of breast cancer at single-cell resolution using virtual reality
Bressan, D.; Mulvey, C. M.; Qosaj, F.; Becker, R.; Grimaldi, F.; Coffey, S.; Vogl, S. L.; Kuett, L.; Catena, R.; Dariush, A.; Gonzalez Fernandez, C.; Gonzalez Solares, E. A.; Al Sa'd, M.; Küpkü Yoldas, A.; Whitmarsh, T.; Falciatori, I.; Watson, S. S.; CRUK IMAXT Grand Challenge Team, ; Joyce, J. A.; Walton, N.; Bodenmiller, B.; Harris, O.; Hannon, G. J.
10.1101/2021.06.28.448342 — cancer biology — Posted on 2021-06-29
306 Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of the matricellular protein Mindin
Badarinath, K.; Dam, B.; Kataria, S.; Zirmire, R. K.; Dey, R.; Singh, R.; Masudi, T.; Sambath, J.; Kumar, P.; Gulyani, A.; He, Y.-W.; Krishna, S.; Jamora, C.
10.1101/2021.06.26.450022 — cell biology — Posted on 2021-06-29
307 A comprehensive approach for artifact-free sample preparation and assessment of mitochondrial morphology in tissue and cultured cells
Hinton, A.; Katti, P.; Christensen, T. A.; Mungai, M.; Shao, J.; Zhang, L.; Trushin, S.; Alghanem, A.; Jaspersen, A.; Geroux, R. E.; Neikirk, K.; Biete, M.; Garza Lopez, E.; Vue, Z.; Beasley, H.; Marshall, A.; Hicsasmaz, I.; Edmonds, R. A. C.; Dajles, A.; Koo, Y. D.; Bacevac, S.; Salisbury, J. L.; Pereira, R. O.; Glancy, B.; Trushina, E.; Abel, E. D.
10.1101/2021.06.27.450055 — cell biology — Posted on 2021-06-29
308 Kidney organoids: A system to study human basement membrane assembly in health and disease
Morais, M. R.; Tian, P.; Lawless, C.; Murtuza-Baker, S.; Hopkinson, L.; Woods, S.; Mironov, A.; Long, D. A.; Gale, D.; Zorn, T. M.; Zent, R.; Lennon, R.
10.1101/2021.06.27.450067 — cell biology — Posted on 2021-06-29
309 Herpes simplex virus 1 inhibits phosphorylation of RNA polymerase II CTD serine-7
Whisnant, A. W.; Dyck Dionisi, O. M.; Grothey, A.; Rappold, J. M.; Marante, A. L.; Subramanian, S. S.; Doelken, L.
10.1101/2021.06.28.450160 — molecular biology — Posted on 2021-06-28
312 Aerobiology in High Latitudes: Evidence of Bacteria Acting as Tracer of Warm Air Mass Advection reaching Northern Antarctic Peninsula
Cataldo, M.; Evangelista, H.; Pereira, J. A. A.; Bertho, A. L.; Pellizari, V.; Kuhn, E.; Sampaio, M.; da Cunha, K. D.; Alencar, A.; AMARAL, C. R. L.
10.1101/2021.06.27.450079 — biophysics — Posted on 2021-06-28
315 Validated machine learning algorithm with sub-clonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity
Pyke, R. M.; Mellacheruvu, D.; Dea, S.; Abbott, C. W.; Zhang, S. V.; McDaniel, L.; Levy, E.; Bartha, G.; West, J.; Snyder, M. M.; Chen, R.; Boyle, S. M.
10.1101/2021.05.20.445052 — bioinformatics — Posted on 2021-06-28
317 The role of Dicer-dependent RNA interference in regulating cross-species communication during fungus-fungus interactions
Piombo, E.; Vetukuri, R. R.; Broberg, A.; Kalyandurg, P. B.; Kushwaha, S.; Jensen, D. F.; Karlsson, M.; Dubey, M.
10.1101/2021.06.28.450161 — genomics — Posted on 2021-06-28
318 31,600-year-old human virus genomes support a Pleistocene origin for common childhood infections
Holtsmark Nielsen, S.; van Dorp, L.; Houldcroft, C. J.; Pedersen, A. G.; Allentoft, M. E.; Vinner, L.; Margaryan, A.; Pavlova, E.; Chasnyk, V.; Nikolskiy, P.; Pitulko, V.; Pimenoff, V. N.; Balloux, F.; Sikora, M.
10.1101/2021.06.28.450199 — evolutionary biology — Posted on 2021-06-28
319 Gut microbiota of ring-tailed lemurs (Lemur catta) vary across natural and captive populations and correlate with environmental microbiota
Bornbusch, S. L.; Greene, L. K.; Rahobilalaina, S.; Calkins, S.; Rothman, R. S.; Clarke, T. A.; LaFleur, M.; Drea, C. M.
10.1101/2021.06.27.450077 — ecology — Posted on 2021-06-28
320 Tau assemblies enter the cytosol of neurons in a cholesterol sensitive manner
Tuck, B. J.; Katsinelos, T.; Miller, L. V. C.; Cheng, S.; Vaysburd, M. J.; Knox, C.; Tredgett, L.; James, L. C.; McEwan, W. A.
10.1101/2021.06.21.449238 — cell biology — Posted on 2021-06-28
323 Fine-scale adaptations to environmental variation and growth strategies drive phyllosphere Methylobacterium diversity.
Leducq, J.-B.; Seyer-Lamontagne, E.; Condrain-Morel, D.; Bourret, G.; Sneddon, D.; Foster, J. A.; Marx, C. J.; Sullivan, J. M.; Shapiro, B. J.; Kembel, S. W.
10.1101/2021.06.04.447128 — microbiology — Posted on 2021-06-28
324 Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy
Ullah, I.; Prevost, J.; Ladinsky, M. S.; Stone, H.; Lu, M.; Anand, S. P.; Beaudoin-Bussieres, G.; Symmes, K.; Benlarbi, M.; Ding, S.; Gasser, R.; Fink, C.; Chen, Y.; Tauzin, A.; Goyette, G.; Bourassa, C.; Medjahed, H.; Mack, M.; Chung, K.; Wilen, C. B.; Dekaban, G. A.; Dikeakos, J. D.; Bruce, E. A.; Kaufmann, D. E.; Stamatatos, L.; McGuire, A.; Richard, J.; Pazgier, M.; Bjorkman, P.; Mothes, W.; Finzi, A.; Kumar, P.; Uchil, P. D.
10.1101/2021.03.22.436337 — immunology — Posted on 2021-06-28
325 Cholinergic modulation of dentate gyrus processing through dynamic reconfiguration of inhibitory circuits
Ogando, M. B.; Pedroncini, O.; Federman, N.; Romano, S. A.; Brum, L. A.; Lanuza, G. M.; Refojo, D.; Marin-Burgin, A.
10.1101/632497 — neuroscience — Posted on 2021-06-28
326 A novel, ataxic mouse model of Ataxia Telangiectasia caused by a clinically relevant nonsense mutation
Perez, H.; Abdallah, M. F.; Chavira, J. I.; Egeland, M. T.; Vo, K. L.; Sanghez, V.; Buechsenschuetz, C. L.; Kim, J. L.; Pind, M.; Nakamura, K.; Hicks, G. G.; Gatti, R. A.; Madrenas, J.; Iacovino, M.; McKinnon, P.; Mathews, P. J.
10.1101/2020.11.23.394098 — neuroscience — Posted on 2021-06-28
328 Cell fitness is an omniphenotype
Jacobs, N. C.; Park, J.; Saccone, N. L.; Peterson, T. R.
10.1101/487157 — systems biology — Posted on 2021-06-28
330 An Experimental Test of the Effects of Redacting Grant Applicant Identifiers on Peer Review Outcomes
Nakamura, R.; Mann, L. S.; Lindner, M. D.; Braithwaite, J.; Chen, M.-C.; Vancea, A.; Byrnes, N.; Durrant, V.; Reed, B.
10.1101/2021.06.25.449872 — scientific communication and education — Posted on 2021-06-28
333 A spatial multi-scale fluorescence microscopy toolbox discloses entry checkpoints of SARS-CoV-2 variants in Vero E6 cells
Storti, B.; Quaranta, P.; Di Primio, C.; Clementi, N.; Mancini, N.; Criscuolo, E.; Spezia, P. G.; Carnicelli, V.; Lottini, G.; Paolini, E.; Freer, G.; Lai, M.; Costa, M.; Beltram, F.; Diaspro, A.; Pistello, M.; Zucchi, R.; Bianchini, P.; Signore, G.; Bizzarri, R.
10.1101/2021.03.31.437907 — biophysics — Posted on 2021-06-28
335 Neural ADMIXTURE: rapid population clustering with autoencoders
Mantes, A. D.; Montserrat, D. M.; Bustamante, C.; Giro-i-Nieto, X.; Ioannidis, A. G.
10.1101/2021.06.27.450081 — genomics — Posted on 2021-06-28
336 ZFP462 targets heterochromatin to transposon-derived enhancers restricting transcription factor binding and expression of lineage-specifying genes
Yelagandula, R.; Stecher, K.; Novatchkova, M.; Michetti, L.; Michlits, G.; Wang, J.; Hofbauer, P.; Pribitzer, C.; Vainorius, G.; Isbel, L.; Mendjan, S.; Schubeler, D.; Elling, U.; Brennecke, J.; Bell, O.
10.1101/2021.06.28.449463 — genetics — Posted on 2021-06-28
339 Speciation in the face of gene flow within the toothed whale superfamily Delphinoidea
Westbury, M. V.; Cabrera, A. A.; Rey-Iglesia, A.; De Cahsan, B.; Hartmann, S.; Lorenzen, E. D.
10.1101/2020.10.23.352286 — evolutionary biology — Posted on 2021-06-28
344 POGZ modulates the DNA damage response in a HP1-dependent manner
Heath, J.; Cheyou, E. S.; Findlay, S.; Luo, V.; Carpio, E. P.; Lee, J.; Djerir, B.; Chen, X.; Morin, T.; Lebeau, B.; Karam, M.; Bagci, H.; Grapton, D.; Ursini-Siegel, J.; Cote, J.-F.; Witcher, M.; richard, s.; Marechal, A.; Orthwein, A.
10.1101/2021.06.28.447216 — molecular biology — Posted on 2021-06-28
345 Enhanced fitness of SARS-CoV-2 variant of concern B.1.1.7, but not B.1.351, in animal models
Ulrich, L.; Halwe, N. J.; Taddeo, A.; Ebert, N.; Schön, J.; Devisme, C.; Trüeb, B. S.; Hoffmann, B.; Wider, M.; Bekliz, M.; Essaidi-Laziosi, M.; Schmidt, M. L.; Niemeyer, D.; Corman, V. M.; Kraft, A.; Godel, A.; Laloli, L.; Kelly, J. N.; Breithaupt, A.; Wylezich, C.; Berenguer Veiga, I. M.; Gultom, M.; Adea, K.; Meyer, B.; Eberhardt, C.; Thomann, L.; Gsell-Albert, M.; Labroussaa, F.; Jores, J.; Summerfield, A.; Drosten, C.; Eckerle, I. A.; Dijkman, R.; Hoffmann, D.; Thiel, V.; Beer, M.; Benarafa, C.
10.1101/2021.06.28.450190 — microbiology — Posted on 2021-06-28
346 A bifluorescent-based assay for the identification of neutralizing antibodies against SARS-CoV-2 variants of concern in vitro and in vivo
Chiem, K.; Vasquez, D. M.; Silvas, J.; Park, J.-G.; Piepenbrink, M.; Sourimant, J.; Lin, M. J.; Greninger, A. L.; Plemper, R. K.; Torrelles, J. B.; Walter, M. R.; de la Torre, J. C.; Kobie, J.; Martinez-Sobrido, L.
10.1101/2021.06.28.450214 — microbiology — Posted on 2021-06-28
347 A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
Ramachandran, S.; Banerjee, N.; Bhattacharya, R.; Lemons, M. L.; Florman, J.; Lambert, C. M.; Touroutine, D.; Alexander, K.; Schoofs, L.; Alkema, M. J.; Beets, I.; Francis, M. M.
10.1101/2020.04.27.064550 — neuroscience — Posted on 2021-06-28
348 c-Fos-MMP-9 pathway in central amygdala mediates approach motivation but not reward consumption
Lebitko, T.; Klaudia, N.; Dzik, J.; Kanigowski, D.; Jedrzejewska-Szmek, J.; Chaturvedi, M.; Jaworski, T.; Nikolaev, T.; Gorkiewicz, T.; Meyza, K.; Urban-Ciecko, J.; Kaczmarek, L.; Knapska, E.
10.1101/2020.04.17.044792 — neuroscience — Posted on 2021-06-28
349 Evaluating the reliability of human brain white matter tractometry
Kruper, J.; Yeatman, J. D.; Richie-Halford, A.; Bloom, D.; Grotheer, M.; Caffarra, S.; Kiar, G.; Karipidis, I. I.; Roy, E.; Chandio, B. Q.; Garyfallidis, E.; Rokem, A.
10.1101/2021.02.24.432740 — neuroscience — Posted on 2021-06-28
350 TNFα increases Tyrosine Hydroxylase expression in human monocytes
Gopinath, A.; Badov, M.; Francis, M.; Shaw, G.; Collins, A.; Miller, D. R.; Hansen, C.; Mackie, P. M.; Tansey, M. G.; Dagra, A.; Madorsky, I.; Ramirez-Zamora, A.; Okun, M.; Streit, W. J.; Khoshbouei, H.
10.1101/2021.04.13.439627 — neuroscience — Posted on 2021-06-28
351 Adolescent Stress Confers Resilience to Traumatic Stress Later in Life: Role of the Prefrontal Cortex
Cotella, E.; Nawreen, N.; Moloney, R.; Martelle, S.; Oshima, K.; Lemen, P.; NiBlack, J.; Julakanti, R.; Fitzgerald, M.; Baccei, M.; Herman, J.
10.1101/2021.03.16.435691 — neuroscience — Posted on 2021-06-28
353 Clinical recovery of Macaca fascicularis infected with Plasmodium knowlesi
Peterson, M. S.; Joyner, C. J.; Brady, J. A.; Wood, J. S.; Cabrera-Mora, M.; Saney, C. L.; Fonseca, L. L.; Cheng, W. T.; Jang, J.; Lapp, S. A.; Soderberg, S. R.; Nural, M. V.; Humphrey, J. C.; Hankus, A.; Machiah, D.; Karpuzoglu, E.; DeBarry, J. D.; MaHPIC-Consortium, ; Tirouvanziam, R.; Kissinger, J. C.; Moreno, A.; Gumber, S.; Voit, E. O.; Gutierrez, J. B.; Cordy, R. J.; Galinski, M. R.
10.1101/2021.06.28.448877 — pathology — Posted on 2021-06-28
354 Inhibition of Casein Kinase 2 induces Cell Death in Chronic Myelogenous Leukemia Cells with Different Mechanisms of Resistance to Tyrosine Kinase Inhibitors
Mitrovsky, O.; Myslivcova, D.; Machackova-Lopotova, T.; Obr, A.; Cermakova, K.; Ransdorfova, S.; Brezinova, J.; Klamova, H.; Zackova, M.
10.1101/2021.06.28.450156 — cancer biology — Posted on 2021-06-28
355 A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1
Johnson, F. D.; Ferrarone, J.; Liu, A.; Brandstadter, C.; Munuganti, R.; Fansworth, D.; Lu, D.; Luu, J.; Sihota, T.; Jansen, S.; Nagelberg, A.; Shi, R.; Forcina, G. C.; Zhang, X.; Cheng, G. S. W.; Spencer Miko, S. E.; de Rappard-Yuswack, G.; Sorenesen, P. H.; Dixon, S. J.; Guha, U.; Becker, K.; Djaballah, H.; Somwar, R.; Varmus, H.; Morin, G. B.; Lockwood, W. W.
10.1101/2021.06.28.450088 — cancer biology — Posted on 2021-06-28
358 An Erwinia amylovora inducible promoter for intragenic improvement of apple fire blight resistance
Gaucher, M.; Righetti, L.; Aubourg, S.; Duge de Bernonville, T.; Brisset, M.-N.; Chevreau, E.; Vergne, E.
10.1101/767772 — bioengineering — Posted on 2021-06-28
359 Convergent adaptation and ecological speciation result from unique genomic mechanisms in sympatric extremophile fishes
Greenway, R. S.; Brown, A. P.; Camarillo, H.; Delich, C.; McGowan, K. L.; Nelson, J. T.; Arias-Rodriguez, L.; Kelley, J. L.; Tobler, M.
10.1101/2021.06.28.450104 — evolutionary biology — Posted on 2021-06-28
363 Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants
Choi, A.; Koch, M.; Wu, K.; Dixon, G.; Oestreicher, J.; Legault, H.; Stewart-Jones, G. B. E.; Colpitts, T.; Pajon, R.; Bennett, H.; Carfi, A.; Edwards, D. K.
10.1101/2021.06.28.449914 — microbiology — Posted on 2021-06-28
364 Global analysis of putative phospholipases in the malaria parasite Plasmodium falciparum reveals critical factors for parasite proliferation
Burda, P.-C.; Ramaprasad, A.; Pietsch, E.; Bielfeld, S.; Söhnchen, C.; Wilcke, L.; Strauss, J.; Schwudke, D.; Sait, A.; Collinson, L. M.; Blackman, M. J.; Gilberger, T.-W.
10.1101/2021.06.28.450158 — microbiology — Posted on 2021-06-28
365 Effect of prophylactic use of intra-nasal oil formulations in the hamster model of Covid-19
Rizvi, Z. A.; Tripathy, M. R.; Sharma, N.; Goswami, S.; Srikanth, N.; Shastry, J.; Mani, S.; Surjit, M.; Awasthi, A.; Dikshit, M.
10.1101/2021.06.25.449990 — microbiology — Posted on 2021-06-28
368 Myeloid cell interferon responses correlate with clearance of SARS-CoV-2
Singh, D. K.; Aladyeva, E.; Das, S.; Singh, B.; Esaulova, E.; Swain, A.; Ahmed, M.; Cole, J.; Moodley, C.; Mehra, S.; Schlesinger, L.; Artyomov, M.; Khader, S. A.; Kaushal, D.
10.1101/2021.06.28.450153 — immunology — Posted on 2021-06-28
369 A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2
Jiang, L.; Driedonks, T.; Lowman, M.; Jong, W. S.; van den Berg van Saparoea, H. B.; Dhakal, S.; Zhou, R.; Caputo, C.; Littlefield, K.; Sitaris, I.; Chen, M. W.; Lima, G.; Gololobova, O.; Smith, B.; Lane, A. P.; Klein, S. L.; Pekosz, A.; Brayton, C. F.; Luirink, J.; Villano, J. S.; Witwer, K. W.
10.1101/2021.06.28.450181 — immunology — Posted on 2021-06-28
372 DeepMP: a deep learning tool to detect DNA base modifications on Nanopore sequencing data
Bonet, J.; Chen, M.; Dabad, M.; Heath, S.; Gonzalez-Perez, A.; Lopez-Bigas, N.; Lagergren, J.
10.1101/2021.06.28.450135 — bioinformatics — Posted on 2021-06-28
373 ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription
Yu, C.; Lei, X.; Chen, F.; Mao, S.; Lv, L.; Liu, H.; Hu, X.; Wang, R.; Shen, L.; Zhang, N.; Meng, Y.; Shen, Y.; Li, P.; Huang, S.; Shao, H.; Lin, C.; Zhang, Z.; Yuan, K.
10.1101/2021.06.28.450127 — cancer biology — Posted on 2021-06-28
376 Detecting quantitative trait loci and exploring chromosomal pairing in autopolyploids using polyqtlR
Bourke, P. M.; Voorrips, R. E.; Hackett, C. A.; van Geest, G.; Willemsen, J. H.; Arens, P.; Smulders, M. J. M.; Visser, R. G. F.; Maliepaard, C.
10.1101/2021.06.28.450123 — genetics — Posted on 2021-06-28
378 A Reevaluation of the Effect of Dietary Restriction on Different Recombinant Inbred (RI) Lines of Male and Female Mice
Unnikrishnan, A.; Matyi, S.; Garrett, K. G.; Ranjo-Bishop, M.; Allison, D. B.; Ejima, K.; Chen, X.; Dickinson, S.; Richardson, A.
10.1101/2021.06.25.449984 — molecular biology — Posted on 2021-06-28
379 A protease-activatable luminescent biosensor andreporter cell line for authentic SARS-CoV-2 infection
Pereyra Gerber, P.; Duncan, L. M.; Greenwood, E. J.; Marelli, S.; Naamati, A.; Teixeira-Silva, A.; Crozier, T. W.; Gabaev, I.; Zhan, J. R.; Mulroney, T. E.; Horner, E. C.; Doffinger, R.; Willis, A. E.; Thanventhiran, J. E.; Protasio, A. V.; Matheson, N. J.
10.1101/2021.03.22.435957 — microbiology — Posted on 2021-06-28
380 Cerebello-cerebral Functional Connectivity Networks in Major Depressive Disorder: A CAN-BIND-1 Study Report
Anteraper, S. A.; Guell, X.; Lee, Y. J.; Raya, J.; Demchenko, I.; Churchill, N. W.; Frey, B. N.; Hassel, S.; Lam, R. W.; MacQueen, G. M.; Milev, R.; Schweizer, T. A.; Strother, S. C.; Whitfield-Gabrieli, S.; Kennedy, S. H.; Bhat, V.; The CAN-BIND Investigator Team,
10.1101/2021.06.25.449819 — neuroscience — Posted on 2021-06-28
381 Circadian modulation of human sleep spindle frequency
Bodizs, R.; Horvath, C. G.; Szalardy, O.; Ujma, P. P.; Simor, P.; Gombos, F.; Kovacs, I.; Genzel, L.; Dresler, M.
10.1101/2021.06.28.450146 — neuroscience — Posted on 2021-06-28
387 Developmental Effects on Relative Use of PEPCK and NADP-ME Pathways of C4 Photosynthesis in Maize
Arp, J. J.; Kambhampati, S.; Chu, K.; Koley, S.; Jenkins, L. M.; Mockler, T. C.; Allen, D. K.
10.1101/2021.06.25.449949 — plant biology — Posted on 2021-06-28
389 Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice
Lewis, J. E.; Woodward, O. R.; Smith, C. A.; Adriaenssens, A. E.; Billing, L.; Brighton, C.; Phillips, B. U.; Tadross, J. A.; Kinston, S. J.; Ciabatti, E.; Gottgens, B.; Tripodi, M.; Hornigold, D.; Baker, D.; Gribble, F. M.; Reimann, F.
10.1101/2021.06.26.450020 — physiology — Posted on 2021-06-28
390 TRIOBP promotes bidirectional radial stiffness gradients within the organ of Corti
Babahosseini, H.; Belyantseva, I.; Yousaf, R.; Tona, R.; Hadi, S.; Wilson, E.; Kitajiri, S.-i.; Frolenkov, G.; Friedman, T. B.; Cartagena-Rivera, A. X.
10.1101/2021.06.28.450090 — biophysics — Posted on 2021-06-28
391 Pan-cancer landscape of AID-related mutations, composite mutations and its potential role in the ICI response
Hernandez-Verdin, I.; Akdemir, K. C.; Ramazzotti, D.; Caravagna, G.; Labreche, K.; Mokhtari, K.; Hoang-Xuan, K.; Peyre, M.; Bielle, F.; Touat, M.; Idbaih, A.; Duval, A.; Sanson, M.; Alentorn, A.
10.1101/2021.06.26.447715 — bioinformatics — Posted on 2021-06-28
392 Mutation in Abl kinase with altered drug binding kinetics indicates a novel mechanism of imatinib resistance
Lyczek, A.; Berger, B.-T.; Rangwala, A. M.; Paung, Y.; Tom, J.; Philipose, H.; Guo, J.; Albanese, S. K.; Robers, M. B.; Knapp, S.; Chodera, J. D.; Seeliger, M. A.
10.1101/2021.06.28.449968 — biochemistry — Posted on 2021-06-28
393 SARS-CoV-2 B.1.617.2 Delta variant emergence and vaccine breakthrough
Mlcochova, P.; Kemp, S. A.; Shanker Dhar, M.; Papa, G.; Meng, B.; Mishra, S.; Whittaker, C.; Mellan, T.; Ferreira, I.; Datir, R.; Collier, D.; Singh, S.; Pandey, R.; Ponnusamy, K.; Radhakrishnan, V. S.; Sato, K.; Sengupta, S.; Brown, J.; Marwal, R.; Ponnusamy, K.; Radhakrishnan, V. S.; Goonawardne, N.; Abdullahi, A.; Devi, P.; Wattal, C.; Caputo, D.; Peacock, T.; Goel, N.; Vaishya, R.; Charles, O.; Chattopadhyay, P.; Agarwal, M.; INSACOG CONSORTIUM, ; NIHR Bioresource Collaboration, ; Mavousian, A.; Hyeon Lee, J.; Barlcay, W.; Bhatt, S.; Flaxman, S.; James, L.; Rakshit, P.; Agrawal, A.; Gupt
10.1101/2021.05.08.443253 — microbiology — Posted on 2021-06-28
395 The role of high cholesterol in age related COVID19 lethality.
Wang, H.; Yuan, Z.; Pavel, M. A.; Jablonski, S. M.; Jablonski, J.; Hobson, R.; Valente, S.; Reddy, C. B.; Hansen, S.
10.1101/2020.05.09.086249 — cell biology — Posted on 2021-06-28
396 The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells
Zhuang, X.; Tsukuda, S.; Wrensch, F.; Wing, P. A.; Schilling, M.; Harris, J. M.; Borrmann, H.; Morgan, S. B.; Cane, J. L.; Mailly, L.; Thakur, N.; Conceicao, C.; Sanghani, H.; Heydmann, L.; Bach, C.; Ashton, A.; Walsh, S.; Tan, T. K.; Schimanski, L.; Huang, K.-Y. A.; Schuster, C.; Watashi, K.; Hinks, T. S.; Jagannath, A.; Vausdevan, S. R.; Bailey, D.; Baumert, T. F.; McKeating, J. A.
10.1101/2021.03.20.436163 — microbiology — Posted on 2021-06-28
397 Progression and Resolution of SARS-1 CoV-2 Infection in Golden Syrian Hamsters
Mulka, K.; Beck, S.; Solis, C.; Johanson, A.; Queen, S.; McCarron, M.; Richardson, M.; Zhou, R.; Marinho, P.; Jedlicka, A.; Guerrero-Martin, S.; Shirk, E.; Braxton, A.; Brockhurst, J.; Creisher, P.; Dhakal, S.; Brayton, C.; Veenhuis, R.; Metcalf Pate, K.; Karakousis, P.; Klein, S. L.; Jain, S. K.; Tarwater, P.; Pekosz, A.; Villano, J.; Mankowski, J.
10.1101/2021.06.25.449918 — pathology — Posted on 2021-06-28
400 CTCF and transcription influence chromatin structure re-configuration after mitosis
Zhang, H.; Lam, J.; Zhang, D.; Vermunt, M.; Lan, Y.; Keller, C. A.; Giardine, B.; Hardison, R. C.; Blobel, G.
10.1101/2021.06.27.450099 — genomics — Posted on 2021-06-28
404 Modified defence peptides from horseshoe crab target and kill bacteria inside host cells
Amiss, A. S.; von Pein, J. B.; Webb, J. R.; Condon, N. D.; Harvey, P. J.; Phan, M.-D.; Schembri, M. A.; Currie, B. J.; Sweet, M. J.; Craik, D. J.; Kapetanovic, R.; Henriques, S. T.; Lawrence, N.
10.1101/2021.06.27.450110 — microbiology — Posted on 2021-06-28
406 SLIMP: Supervised learning of metabolite-protein interactions from co-fractionation mass spectrometry data
Zühlke, B. M.; Sokolowska, E. M.; Luzarowski, M.; Schlossarek, D.; Chodasiewicz, M.; Leniak, E.; Skirycz, A.; Nikoloski, Z.
10.1101/2021.06.16.448636 — systems biology — Posted on 2021-06-28
408 GTL1 is required for a robust root hair growth response to avoid nutrient overloading
Shibata, M.; Favero, D. S.; Takebayashi, R.; Kawamura, A.; Rymen, B.; Hosokawa, Y.; Sugimoto, K.
10.1101/2021.06.27.450011 — plant biology — Posted on 2021-06-28
413 Single-cell reconstitution reveals persistence of clonal heterogeneity in the murine hematopoietic system
Kubasova, N.; F. Alves-Pereira, C.; Gupta, S.; Vinogradova, S.; Gimelbrant, A.; M. Barreto, V.
10.1101/2021.06.28.450120 — genetics — Posted on 2021-06-28
416 Gut microbiota of ring-tailed lemurs (Lemur catta) vary across natural and captive populations and correlate with environmental microbiota
Bornbusch, S. L.; Greene, L. K.; Rahobilalaina, S.; Calkins, S.; Rothman, R. S.; Clarke, T. A.; LaFleur, M.; Drea, C. M.
10.1101/2021.06.27.450077 — ecology — Posted on 2021-06-28
418 TLR4 regulation in human fetal membranes as an explicative mechanism of a pathological preterm case.
Belville, C.; Ponelle-Chachuat, F.; Rouzaire, M.; Gross, C.; Pereira, B.; Gallot, D.; Sapin, V.; BLANCHON, L.
10.1101/2021.06.28.450131 — cell biology — Posted on 2021-06-28
422 Pseudomonas aeruginosa infection reveals a Caspase-1-dependent neutrophil pyroptosis pathway that restrains damaging Histone release
Planes, R.; Santoni, K.; Bagayoko, S.; Pericat, D.; Bordignon, P.-J.; Hessel, A.; Pinilla, M.; Leon-Ycaza, S. A.; Bellard, E.; Mazeres, S.; Abderrahim, R.; Doz-Deblauwe, E.; Aylward, F.; Romboust, Y.; Winter, N.; Girard, J.-P.; Schiltz, O.; Pham, C.; Lamkanfi, M.; Paget, C.; Cougoule, C.; Gonzalez de Peredo, A.; Poincloux, R.; Lefrancais, E.; Meunier, E.
10.1101/2021.06.28.450116 — immunology — Posted on 2021-06-28
423 Carbohydrate sulfation as a mechanism for fine-tuning Siglec ligands
Jung, J.; Enterina, J. R.; Bui, D. T.; Mozaneh, F.; Lin, P.-H.; Nitin, H.; Kuo, C.-W.; Rodrigues, E.; Bhattacherjee, A.; Raeisimakiani, P.; Daskhan, G. C.; St. Laurent, C. D.; Khoo, K.-H.; Mahal, L. K.; Zandberg, W. F.; Huang, X.; Klassen, J. S.; Macauley, M. S.
10.1101/2021.06.27.450109 — immunology — Posted on 2021-06-28
424 Chronic adolescent stress increases exploratory behavior but does not change the acute stress response in adult male C57BL/6 mice
Sturman, O.; von Ziegler, L. M.; Privitera, M.; Waag, R.; Duss, S. N.; Vermeiren, Y.; de Deyn, P. P.; Bohacek, J.
10.1101/2021.06.25.449581 — neuroscience — Posted on 2021-06-28
428 Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition
Abraham, A. D.; Casello, S. M.; Schattauer, S. S.; Wong, B. A.; Mizuno, G. O.; Mahe, K.; Tian, L.; Land, B. B.; Chavkin, C.
10.1101/2021.06.27.450102 — neuroscience — Posted on 2021-06-28
432 Origins and timing of emerging lesions in advanced renal cell carcinoma
Wallace, A.; Porten, S.; Lo, A. A.; Oreper, D.; Lounsbury, N.; Havnar, C.; Pechuan-Jorge, X.; Zill, O.; Meng, M.
10.1101/2021.06.27.450111 — cancer biology — Posted on 2021-06-28
434 Aerobiology in High Latitudes: Evidence of Bacteria Acting as Tracer of Warm Air Mass Advection reaching Northern Antarctic Peninsula
AMARAL, C. R. L.; Alencar, A.; Sampaio, M.; Kuhn, E.; Pellizari, V.; Bertho, A. L.; Pereira, J. A. A.; Evangelista, H.; Cataldo, M.
10.1101/2021.06.27.450079 — biophysics — Posted on 2021-06-28
438 Pancreatic cancer risk predicted from disease trajectories using deep learning
Placido, D.; Yuan, B.; Hu, J. X.; Haue, A. D.; Yuan, C.; Kim, J.; Umeton, R.; Antell, G.; Chowdhury, A.; Franz, A.; Brais, L.; Andrews, E.; Regev, A.; Kraft, P.; Wolpin, B. M.; Rosenthal, M.; Brunak, S.; Sander, C.
10.1101/2021.06.27.449937 — bioinformatics — Posted on 2021-06-28
440 Robust integration of single-cell cytometry datasets
Pedersen, C. B.; Dam, S. H.; Barnkob, M. B.; Leipold, M. D.; Purroy, N.; Rassenti, L. Z.; Kipps, T. J.; Nguyen, J.; Lederer, J. A.; Gohil, S. H.; Wu, C. J.; Olsen, L. R.
10.1101/2021.06.28.450128 — bioinformatics — Posted on 2021-06-28
441 Injectable Nanoparticle-Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies
Correa, S.; Gale, E. C.; Mayer, A. T.; Xiao, Z.; Liong, C.; Klich, J. H.; Brown, R. A.; Meany, E.; Saouaf, O.; Maikawa, C. L.; Grosskopf, A. K.; Mann, J. L.; Idoyaga, J.; Appel, E.
10.1101/2021.06.27.449987 — bioengineering — Posted on 2021-06-28
442 Structure of the mini-RNA-guided endonuclease CRISPR-Cas{Phi}3
Carabias del Rey, A.; Fuglsang, A.; Temperini, P.; Pape, T.; Sofos, N.; Stella, S.; Erlendsson, S.; Montoya, G.
10.1101/2021.06.27.449965 — biochemistry — Posted on 2021-06-28
444 Neural ADMIXTURE: rapid population clustering with autoencoders
Mantes, A. D.; Montserrat, D. M.; Bustamante, C.; Giro-i-Nieto, X.; Ioannidis, A. G.
10.1101/2021.06.27.450081 — genomics — Posted on 2021-06-28
445 Oct4 primarily controls enhancer activity rather than accessibility
Xiong, L.; Tolen, E. A.; Choi, J.; Caizzi, L.; Adachi, K.; Lidschreiber, M.; Cramer, P.; Schoeler, H. R.
10.1101/2021.06.28.450119 — genomics — Posted on 2021-06-28
448 MicroRNA-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis
Chen, J.; Gao, C.; Lin, X.; Ning, Y.; He, W.; Zheng, C.; Zhang, D.; Yan, L.; Jiang, B.; Zhao, Y.; Hossen, M. A.; Han, C.
10.1101/2021.06.27.449895 — developmental biology — Posted on 2021-06-28
453 Conservation of locomotion-induced oculomotor activity through evolution in higher tetrapods
Franca de Barros, F.; Bacque-Cazenave, J.; Taillebuis, C.; Courtand, G.; Manuel, M.; Bras, H.; Tagliabue, M.; Combes, D.; Lambert, F. M.; Beraneck, M.
10.1101/2021.06.26.450039 — neuroscience — Posted on 2021-06-28
454 Electrical neuromodulation biases brightness perception of flickering light
Fiene, M.; Radecke, J.-O.; Misselhorn, J.; Sengelmann, M.; Herrmann, C. S.; Schneider, T. R.; Schwab, B. C.; Engel, A. K.
10.1101/2021.06.26.450021 — neuroscience — Posted on 2021-06-28
460 4sUDRB-sequencing for genome-wide transcription bursting quantification in breast cancer cells
Beckman, W. F.; Lermo Jimenez, M. A.; Moerland, P. D.; Westerhoff, H. V.; Verschure, P. J.
10.1101/2020.12.23.424175 — molecular biology — Posted on 2021-06-28
461 Differentiating amyloid beta spread in autosomal dominant and sporadic Alzheimer's disease
Levitis, E.; Vogel, J. W.; Funck, T.; Halchinski, V.; Gauthier, S.; Voglein, J.; Levin, J.; Benzinger, T.; Iturria-Medina, Y.; Evans, A. C.; Alzheimer's Disease Neuroimaging Initiative, ; Dominantly Inherited Alzheimer Network,
10.1101/2021.06.25.449939 — neuroscience — Posted on 2021-06-28
463 Adaptation of Bacillus thuringiensis to plant colonisation affects differentiation and toxicity
Lin, Y.; Alstrup, M.; Pang, J. K. Y.; Maroti, G.; Er-Rafik, M.; Tourasse, N.; Okstad, O. A.; Kovacs, A. T.
10.1101/2020.12.03.410076 — microbiology — Posted on 2021-06-28
464 Precise exogenous insertion and sequence replacements in poplar by simultaneous HDR overexpression and NHEJ suppression using CRISPR-Cas9
Movahedi, A.; Wei, H.; Zhou, X.; C. Fountain, J.; Chen, Z.-H.; Mu, Z.; Sun, W.; Zhang, J.; Li, D.; Guo, B.; K. Varshney, R.; Yang, L.; Zhuge, Q.
10.1101/2020.07.04.188219 — plant biology — Posted on 2021-06-28
466 Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen
Murray, G.; Balmer, A. J.; Herbert, J.; Hadijirn, N. F.; Kemp, C. L.; Matuszewska, M.; Bruchmann, S.; Hossain, A. S. M. M.; Gottschalk, M.; Tucker, A. W.; Miller, E.; Weinert, L. A.
10.1101/2021.04.12.439332 — evolutionary biology — Posted on 2021-06-28
468 Computational mechanisms for neural representation of words
Fu, Z.; Wang, X.; Wang, X.; Yang, H.; Wang, J.; Wei, T.; Liao, X.; Liu, Z.; Chen, H.; Bi, Y.
10.1101/2021.06.27.450093 — neuroscience — Posted on 2021-06-27
470 CSDE1 is a Post-Transcriptional Regulator of the LDL Receptor
Smith, G. A.; Padmanabhan, A.; Lau, B. H.; Pampana, A.; Li, L.; Lee, Y. C.; Pelonero, A.; Nishino, T.; Sadagopan, N.; Jain, R.; Natarajan, P.; Wu, R. S.; Black, B. L.; Srivastava, D.; Shokat, K.; Chorba, J. S.
10.1101/2020.08.03.235028 — genomics — Posted on 2021-06-27
472 Post-embryonic development and aging of the appendicular skeleton in Ambystoma mexicanum
Riquelme-Guzman, C.; Schuez, M.; Böhm, A.; Knapp, D.; Edwards-Jorquera, S.; Ceccarelli, A. S.; Chara, O.; Rauner, M.; Sandoval-Guzman, T.
10.1101/2021.03.05.434057 — developmental biology — Posted on 2021-06-27
473 Microtubule inhibitors identified through non-biased screening enhance DNA transfection efficiency by delaying p62-dependent ubiquitin recruitment
Tsuchiya, M.; Ogawa, H.; Watanabe, K.; Koujin, T.; Mori, C.; Nunomura, K.; Lin, B.; Tani, A.; Hiraoka, Y.; Haraguchi, T.
10.1101/2021.05.13.443985 — cell biology — Posted on 2021-06-27
476 Transcriptional activation of auxin biosynthesis drives developmental reprogramming of differentiated cells
Sakamoto, Y.; Kawamura, A.; Suzuki, T.; Segami, S.; Maeshima, M.; Polyn, S.; De Veylder, L.; Sugimoto, K.
10.1101/2021.06.26.450054 — plant biology — Posted on 2021-06-27
477 Cryo-EM structures of human TMEM120A and TMEM120B
Ke, M.; Yu, Y.; Zhao, C.; Lai, S.; Su, Q.; Yuan, W.; Yang, L.; Deng, D.; Wu, K.; Zeng, W.; Geng, J.; Wu, J.; Yan, Z.
10.1101/2021.06.27.450060 — biophysics — Posted on 2021-06-27
479 Genetic basis and dual adaptive role of floral pigmentation in sunflowers
Todesco, M.; Bercovich, N.; Kim, A.; Imerovski, I.; Owens, G. L.; Dorado Ruiz, O.; Holalu, S. V.; Madilao, L. L.; Jahani, M.; Legare, J.-S.; Blackman, B. K.; Rieseberg, L. H.
10.1101/2021.06.26.449999 — evolutionary biology — Posted on 2021-06-27
480 Large Mammals Have More Powerful Antibacterial Defenses Than Expected from Their Metabolic Rates
Downs, C. J.; Schoenle, L. A.; Goolsby, E. W.; Oakey, S. J.; Ball, R.; Jiang, R. H.; Klasing, K. C.; Martin, L. B.
10.1101/2020.09.04.242107 — ecology — Posted on 2021-06-27
481 HIV-2/SIV Vpx antagonises NF-B activation by targeting p65
Fink, D. L.; Cai, J.; Whelan, M. V.; Monit, C.; Maaluquer de Motes, C.; Towers, G. J.; Sumner, R. P.
10.1101/2021.06.26.450035 — molecular biology — Posted on 2021-06-27
482 A Machine Learning Model of Microscopic Agglutination Test for Diagnosis of Leptospirosis
Oyamada, Y.; Ozuru, R.; Masuzawa, T.; Miyahara, S.; Nikaido, Y.; Obata, F.; Saito, M.; Villanueva, S. Y. A. M.; Fujii, J.
10.1101/2020.12.08.410712 — microbiology — Posted on 2021-06-27
484 Feedback processing in attack and defense conflicts: a neurophysiological study
Paiva, T. O.; Coelho, R. C.; Pasion, R.; Dias-Oliveira, E.; De Dreu, C.; Barbosa, F.
10.1101/2021.06.25.449933 — neuroscience — Posted on 2021-06-27
486 Automated movement assessment in stroke rehabilitation
Ahmed, T.; Thopalli, K.; Rikakis, T.; Turaga, P.; Kelliher, A.; Huang, J.-B.; Wolf, S. L.
10.1101/2021.06.25.449936 — neuroscience — Posted on 2021-06-27
488 Metabolic resilience is encoded in genome plasticity
Agudelo, L. Z.; Tuyeras, R. V.; Llinares, C.; Morcuende, A.; Park, Y.; Sun, N.; Kuosmanen, S. M.; Atabaki-Pasdar, N.; Ho, L.-L.; Galani, K.; Franks, P. W.; Kutlu, B.; Grove, K.; Femenia, T.; Kellis, M.
10.1101/2021.06.25.449953 — systems biology — Posted on 2021-06-27
489 Herbicidal activity of fluoroquinolone derivatives
Wallace, M. D.; Debowski, A. W.; Sukhoverkov, K. V.; Mylne, J. S.; Stubbs, K. A.
10.1101/2021.06.26.450056 — plant biology — Posted on 2021-06-27
491 MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect
Tareen, A.; Kooshkbaghi, M.; Posfai, A.; Ireland, W. T.; McCandlish, D. M.; Kinney, J. B.
10.1101/2020.07.14.201475 — bioinformatics — Posted on 2021-06-27
495 Host-parasite coevolution promotes innovation through deformations in fitness landscapes
Gupta, A.; Zaman, L.; Strobel, H. M.; Gallie, J.; Burmeister, A. R.; Kerr, B.; Tamar, E. S.; Kishony, R.; Meyer, J. R.
10.1101/2021.06.25.449783 — evolutionary biology — Posted on 2021-06-27
496 Where there's smoke, there's fuel: predicting Great Basin rangeland wildfire
Smith, J. T.; Allred, B. W.; Boyd, C. S.; Davies, K. W.; Jones, M. O.; Kleinhesselink, A. R.; Naugle, D. E.
10.1101/2021.06.25.449963 — ecology — Posted on 2021-06-27
497 Bmper is required for morphogenesis of the anterior and posterior semicircular canal ducts in the developing zebrafish inner ear
Baxendale, S.; Maier, E. C.; Obholzer, N. D.; Burbridge, S.; Zinski, J.; Tuazon, F. B.; van Hateren, N. J.; Romero, M. M. G.; Marzo, M.; Yokoya, K.; Knight, R. D.; Megason, S. G.; Mullins, M. C.; Whitfield, T. T.
10.1101/2021.06.27.450014 — developmental biology — Posted on 2021-06-27
499 Anaerobic conditions unmask antimicrobial resistance
Creasy-Marrazzo, A.; Saber, M. M.; Kamat, M.; Bailey, L. S.; Qadri, F.; Basso, K. B.; Shapiro, B. J.; Nelson, E. J.
10.1101/2021.06.26.450051 — microbiology — Posted on 2021-06-27
500 Microbiota responses to different prebiotics are conserved within individuals and associated with habitual fiber intake
Holmes, Z. C.; Villa, M. M.; Durand, H. K.; Jiang, S.; Dallow, E. P.; Petrone, B. L.; Silverman, J. D.; Lin, P.-H.; David, L. A.
10.1101/2021.06.26.450023 — microbiology — Posted on 2021-06-27
501 Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights from Experimental and Molecular Dynamics Simulations Studies
Ting, D. S. J.; Li, J.; Verma, C. S.; Goh, E. T. L.; Nubile, M.; Mastropasqua, L.; Said, D. G.; Beuerman, R. W.; Lakshminarayanan, R.; Mohammed, I.; Dua, H. S.
10.1101/2021.06.26.450050 — microbiology — Posted on 2021-06-27
502 Candida albicans Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract
McDonough, L.; Mishra, A. A.; Tosini, N.; Kakade, P.; Penumutchu, S.; Liang, S.-H.; Maufrais, C.; Zhai, B.; Taur, Y.; Belenky, P.; Bennett, R. J.; Hohl, T. J.; Koh, A. Y.; Ene, I. V.
10.1101/2021.06.27.450080 — microbiology — Posted on 2021-06-27
503 Resolving the structure of phage-bacteria interactions in the context of natural diversity
Kauffman, K. M.; Chang, W. K.; Brown, J. M.; Hussain, F. A.; Yang, J. Y.; Polz, M. F.; Kelly, L.
10.1101/2021.06.27.449121 — microbiology — Posted on 2021-06-27
504 Longitudinal accumulation of in vivo and in vitro-grown Treponema pallidum subsp. pallidum TprK variants in the presence and absence of immune pressure
Lin, M. J.; Haynes, A.; Addetia, A.; Lieberman, N. A. P.; Phung, Q.; Xie, H.; Nguyen, T. V.; Molini, B. J.; Lukehart, S. A.; Giacani, L.; Greninger, A. L.
10.1101/2021.06.26.450029 — microbiology — Posted on 2021-06-27
508 Ipsilesional motor cortex activation with high-force unimanual handgrip contractions of the less-affected limb in participants with stroke
Andrushko, J. W.; Gould, L.; Renshaw, D. W.; Forrester, S.; Kelly, M. E.; Linassi, G.; Mickleborough, M.; Oates, A.; Hunter, G.; Borowsky, R.; Farthing, J. P.
10.1101/2021.06.25.449456 — neuroscience — Posted on 2021-06-27
509 Temporal derivative computation in the dorsal raphe network revealed by an experimentally-driven augmented integrate-and-fire modeling framework
Harkin, E. F.; Payeur, A.; Lynn, M. B.; Boucher, J.-F.; Caya-Bissonnette, L.; Cyr, D.; Stewart, C.; Longtin, A.; Naud, R.; Beïque, J.-C.
10.1101/2021.06.25.449907 — neuroscience — Posted on 2021-06-27
512 Age-related change in adult chimpanzee social network integration
Thompson Gonzalez, N.; Machanda, Z.; Otali, E.; Muller, M. N.; Enigk, D. K.; Wrangham, R.; Emery Thompson, M.
10.1101/2021.06.25.449973 — animal behavior and cognition — Posted on 2021-06-27
513 Endosomes facilitate mitochondrial clearance by enhancing Parkin recruitment to mitochondria
Ravindran, R.; Velikkakath, A. K. G.; Narendradev, N. D.; Chandrasekharan, A.; Santhoshkumar, T. R.; Srinivasula, S. M.
10.1101/2020.02.19.955880 — cell biology — Posted on 2021-06-27
514 Massive export of diazotrophs across the tropical south Pacific Ocean
Bonnet, S.; Benavides, M.; Le Moigne, F. A. C.; Camps, M.; Torremocha, A.; Grosso, O.; Spungin, D.; Berman-Frank, I.; Garczarek, L.; Cornejo-Castillo, F.
10.1101/2021.05.07.442706 — microbiology — Posted on 2021-06-27
515 Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio).
Gemmer, A.; Mirkes, K.; Anneser, L.; Eilers, T.; Kibat, C.; Mathuru, A.; Ryu, S.; Schuman, E.
10.1101/2021.06.26.449566 — neuroscience — Posted on 2021-06-27
516 Activation of the type 3 secretion system of enteropathogenic E. coli leads to remodeling of its membrane composition
Zacharia, A.; Pal, R. R.; Katsowich, N.; Mannully, C. T.; ibrahim, a.; Alfandary, S.; Serruya, R.; Baidya, A.; Ben-Yehuda, S.; Rosenshine, I.; Moussaieff, A.
10.1101/2020.12.17.423234 — systems biology — Posted on 2021-06-27
517 Dominant Effect Of Host Genetics On Skin Microbiota Composition In Homeostasis And Wound Healing
Galbraith, J.; Legrand, J.; Muller, N.; Baz, B.; Togher, K.; Matigian, N.; Kang, S.; Young, S.; Mortlock, S.; Roy, E.; Morahan, G.; Walker, G.; Morrison, M.; Khosrotehrani, K.
10.1101/2021.06.20.449197 — systems biology — Posted on 2021-06-27
522 Niche partitioning facilitates coexistence of closely related gut bacteria
Brochet, S.; Quinn, A.; Mars, R. A. T.; Neuschwander, N.; Sauer, U.; Engel, P.
10.1101/2021.03.12.434400 — microbiology — Posted on 2021-06-26
524 Genomic miscellany and allelic frequencies of Plasmodium falciparum msp-1, msp-2 and glurp in parasite isolates
Ullah, I.; Afridi, S. G.; Israr, M.; Khan, A.; Ali, A.; Jabeen, H.; Raasool, A.; Akbar, F.; Shah, M.
10.1101/2021.06.25.449861 — zoology — Posted on 2021-06-26
527 Genetic evidence for environment-dependent hybrid incompatibilities in threespine stickleback
Thompson, K. A.; Peichel, C. L.; Rennison, D. J.; McGee, M. D.; Albert, A. Y. K.; Vines, T. H.; Greenwood, A. K.; Wark, A. R.; Brandvain, Y.; Schumer, M.; Schluter, D.
10.1101/2021.06.24.449805 — evolutionary biology — Posted on 2021-06-26
529 RetroCHMP3 Blocks Budding of Enveloped Viruses Without Blocking Cytokinesis
Rheinemann, L.; Downhour, D. M.; Bredbenner, K.; Mercenne, G.; Davenport, K. A.; Schmitt, P. T.; Necessary, C. R.; McCullough, J.; Schmitt, A. P.; Simon, S. M.; Sundquist, W. I.; Elde, N. C.
10.1101/2020.08.30.273656 — immunology — Posted on 2021-06-26
532 Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs
West, P. J.; Thomson, K.; Billingsley, P.; Pruess, T.; Rueda, C.; Saunders, G. W.; Smith, M. D.; Metcalf, C. S.; Wilcox, K. S.
10.1101/2020.12.03.410266 — neuroscience — Posted on 2021-06-26
535 Tipping-point analysis uncovers critical transition signals from gene expression profiles
Yang, X. H.; Wang, Z.; Goldstein, A.; Sun, Y.; Rowton, M.; Wang, Y.; Griggs, D.; Moskowitz, I. P.; Cunningham, J.
10.1101/668442 — systems biology — Posted on 2021-06-26
536 Computed tomography reveals hip dysplasiain the extinct Pleistocene saber-tooth cat Smilodon
Balisi, M. A.; Sharma, A. K.; Howard, C. M.; Shaw, C. A.; Klapper, R.; Lindsey, E. L.
10.1101/2020.01.07.897348 — paleontology — Posted on 2021-06-26
538 Estimating effects of parents' cognitive and non-cognitive skills on offspring education using polygenic scores
Demange, P. A.; Hottenga, J. J.; Abdellaoui, A.; Eilertsen, E. M.; Malanchini, M.; Domingue, B. W.; de Zeeuw, E. L.; Rimfeld, K.; Eley, T.; Boomsma, D. I.; van Bergen, E.; Breen, G.; Nivard, M. G.; Cheesman, R.
10.1101/2020.09.15.296236 — genetics — Posted on 2021-06-26
540 Towards the Interpretability of Deep Learning Models for Human Neuroimaging
Hofmann, S. M.; Beyer, F.; Lapuschkin, S.; Markus, L.; Mueller, K.-R.; Villringer, A.; Samek, W.; Witte, A. V.
10.1101/2021.06.25.449906 — neuroscience — Posted on 2021-06-26
543 A lineage tree-based hidden Markov model to quantify cellular heterogeneity and plasticity
Mohammadi, F.; Visagan, S.; Gross, S. M.; Karginov, L.; Lagarde, J.; Heiser, L. M.; Meyer, A. S.
10.1101/2021.06.25.449922 — systems biology — Posted on 2021-06-26
550 New intranasal and injectable gene therapy for healthy life extension
Zhu, H.; Jaijyan, D. K.; Selariu, A.; Cruz-cosme, R.; Tong, M.; Yang, S.; Church, G.; Kekich, D.; Sadoshima, J.; Tang, Q.; Parrish, E.
10.1101/2021.06.26.449305 — cell biology — Posted on 2021-06-26
551 Gestationally-Dependent Immune Organization at the Maternal-Fetal Interface
Moore, A. R.; Vivanco Gonzalez, N.; Plummer, K. A.; Mitchel, O. R.; Kaur, H.; Rivera, M.; Collica, B.; Bendall, S. C.; Palmer, T. D.
10.1101/2021.06.25.449807 — immunology — Posted on 2021-06-26
552 A unique cerebellar pattern of microglia activation in a mousemodel of encephalopathy of prematurity
Klein, L.; Van Steenwinckel, J.; Fleiss, B.; Scheuer, T.; buehrer, C.; Faivre, V.; Bokobza, C.; Lemoine, S.; Blugeon, C.; Schwendimann, L.; Csaba, Z.; Vousden, D. A.; Lerch, J. P.; Vernon, A. C.; Gressens, P.; Schmitz, T.
10.1101/2021.06.26.449853 — neuroscience — Posted on 2021-06-26
556 Progression and Resolution of SARS-1 CoV-2 Infection in Golden Syrian Hamsters
Mulka, K.; Beck, S.; Solis, C.; Johanson, A.; Queen, S.; McCarron, M.; Richardson, M.; Zhou, R.; Marinho, P.; Jedlicka, A.; Guerrero-Martin, S.; Shirk, E.; Braxton, A.; Brockhurst, J.; Creisher, P.; Dhakal, S.; Brayton, C.; Veenhuis, R.; Metcalf Pate, K.; Karakousis, P.; Klein, S. L.; Tarwater, P.; Pekosz, A.; Villano, J.; Jain, S. K.; Mankowski, J.
10.1101/2021.06.25.449918 — pathology — Posted on 2021-06-26
565 A wAlbB Wolbachia transinfection displays stable phenotypic effects across divergent Aedes aegypti mosquito backgrounds
Ross, P. A.; Gu, X.; Robinson, K. L.; Yang, Q.; Cottingham, E.; Zhang, Y.; Yeap, H. L.; Xu, X.; Endersby-Harshman, N. M.; Hoffmann, A. A.
10.1101/2021.06.25.450002 — evolutionary biology — Posted on 2021-06-26
569 Successional stages in infant gut microbiota maturation
Beller, L.; Deboutte, W.; Falony, G.; Vieira Silva, S.; Tito, R.; Valles-Colomer, M.; Rymenans, L.; Jansen, D.; Van Espen, L.; Papadaki, M. I.; Shi, C.; Yinda, K. C.; Zeller, M.; Faust, K.; Van Ranst, M.; Raes, J.; Matthijnssens, J.
10.1101/2021.06.25.450009 — microbiology — Posted on 2021-06-26
571 Knocking out AtCALS7 disturbs photoassimilate distribution and weakens defence against phytoplasma infection
Bernardini, C.; Levy, A.; Buoso, S.; Loschi, A.; Santi, S.; Martini, M.; Bosetto, F.; Welker, S.; Suh, J.-H.; Wang, Y.; Vincent, C.; Pierre, M.; Van Bel, A.; Musetti, R.
10.1101/2021.06.25.449948 — plant biology — Posted on 2021-06-26
573 Performance characteristics of next-generation sequencing for antimicrobial resistance gene detection in genomes and metagenomes
Rooney, A. M.; Raphenya, A. R.; Melano, R. G.; Seah, C.; Yee, N. R.; MacFadden, D. R.; McArthur, A. G.; Schneeberger, P. H. H.; Coburn, B.
10.1101/2021.06.25.449921 — bioinformatics — Posted on 2021-06-26
574 An acetyl-click screening platform identifies a small molecule inhibitor of Histone Acetyltransferase 1 (HAT1) with anti-tumor activity
Gruber, J. J.; Rangarajan, A.; Chou, T.; Geller, B. S.; Banuelos, S.; Greenhouse, R.; Snyder, M.; Lipchik, A. M.
10.1101/2021.06.25.449993 — biochemistry — Posted on 2021-06-26
575 Large structural variations in the haplotype-resolved African cassava genome.
Mansfeld, B. N.; Boyher, A.; Berry, J. C.; Wilson, M.; Ou, S.; Polydore, S.; Michael, T. P.; Fahlgren, N.; Bart, R.
10.1101/2021.06.25.450005 — genomics — Posted on 2021-06-26
576 Mutations in PIKFYVE cause autosomal dominant congenital cataract
Mei, S.; Wu, Y.; Wang, Y.; Cui, Y.; Zhang, M.; Zhang, T.; Huang, X.; Yu, S.; Yu, T.; Zhao, J.
10.1101/2021.06.25.449865 — genomics — Posted on 2021-06-26
577 Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
Lopez-Hernandez, T.; Takenaka, K.-i.; Mori, Y.; Kongpracha, P.; Nagamori, S.; Haucke, V.; Takamori, S.
10.1101/2021.06.24.449713 — neuroscience — Posted on 2021-06-26
578 Intraspecific diversity observed in the wild tomato species Solanum chilense in initial immune responses towards a glucan elicitor.
Kahlon, P. S.; Förner, A.; Muser, M.; Oubounyt, M.; Gigl, M.; Hammerl, R.; Baumbach, J.; Hückelhoven, R.; Dawid, C.; Stam, R.
10.1101/2021.06.25.449942 — plant biology — Posted on 2021-06-26
583 Genetic Encoding of a Highly Photostable, Long Lifetime Fluorescent Amino Acid for Imaging in Mammalian Cells
Jones, C. M.; Robkis, D. M.; Blizzard, R. J.; Munari, M.; Venkatesh, Y.; Mihaila, T. S.; Eddins, A. J.; Mehl, R. A.; Zagotta, W. N.; Gordon, S. E.; Petersson, E. J.
10.1101/2021.04.05.438526 — biochemistry — Posted on 2021-06-25
586 The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior
Levine, O. B.; Skelly, M. J.; Miller, J. D.; Rivera-Irizarry, J. K.; Rowson, S. A.; DiBerto, J. F.; Rinker, J. A.; Thiele, T. E.; Kash, T. L.; Pleil, K. E.
10.1101/2020.05.04.075051 — neuroscience — Posted on 2021-06-25
587 The Neuroanatomy of Speech Processing: A Large-Scale Lesion Study
Rogalsky, C.; Basilakos, A.; Rorden, C.; Pillay, S.; LaCroix, A. N.; Keator, L.; Mickelsen, S.; Anderson, S. W.; Love, T.; Fridriksson, J.; Binder, J.; Hickok, G.
10.1101/2020.04.02.022822 — neuroscience — Posted on 2021-06-25
588 Transcriptomic similarities and differences between mouse models and human Alzheimer's Disease
De Bastiani, M. A.; Bellaver, B.; Carello-Collar, G.; Forner, S.; Martini, A. C.; Pascoal, T. A.; Zimmer, E. R.
10.1101/2021.06.09.447404 — neuroscience — Posted on 2021-06-25
591 Synaptic integration by co-localized G protein-coupled receptors in presynaptic terminals
Church, E.; Hamid, E.; Zurawski, Z. P.; Potcoava, M.; Flores-Barrera, E.; Caballero, A.; Tseng, K. Y.; Alford, S.
10.1101/2020.11.12.362491 — neuroscience — Posted on 2021-06-25
595 A Bayesian Multivariate Mixture Model for Spatial Transcriptomics Data
Allen, C.; Chang, Y.; Neelon, B.; Chang, W.; Kim, H.; Li, Z.; Ma, Q.; Chung, D.
10.1101/2021.06.23.449615 — bioinformatics — Posted on 2021-06-25
596 Miniaturizing wet scrubbers for aerosolized droplet capture
Lee, U. N.; van Neel, T. L.; Lim, F. Y.; Khor, J. W.; He, J.; Vaddi, R. S.; Ong, A. Q.; Tang, A.; Berthier, J.; Meschke, J. S.; Novosselov, I. V.; Theberge, A. B.; Berthier, E.
10.1101/2021.03.23.436614 — bioengineering — Posted on 2021-06-25
599 The Kinship Matrix: Inferring the Kinship Structure of a Population from its Demography
Coste, C. F. D.; Bienvenu, F.; Ronget, V.; Ramirez-Loza, J.-P.; Cubaynes, S.; Pavard, S.
10.1101/2021.04.12.439517 — ecology — Posted on 2021-06-25
600 A steroid hormone regulates growth in response to oxygen availability
Kapali, G.; Callier, V.; Broeker, H.; Tank, P.; Gascoigne, S.; Harrison, J.; Shingleton, A. W.
10.1101/2021.06.25.449962 — developmental biology — Posted on 2021-06-25
601 Coordinated Action of Multiple Transporters in the Acquisition of Essential Cationic Amino Acids by the Intracellular Parasite Toxoplasma gondii
Fairweather, S. J.; Rajendran, E.; Blume, M.; Javed, K.; Steinhoefel, B.; McConville, M. J.; Kirk, K.; Broer, S.; van Dooren, G. G.
10.1101/2021.06.25.450001 — microbiology — Posted on 2021-06-25
602 Enhanced FcγRIII/CD16 activation by discrete ligands as independent correlates of disease severity in COVID-19 patients
Ankerhold, J.; Giese, S.; Kolb, P.; Maul-Pavicic, A.; Goeppert, N.; Ciminski, K.; Kreutz, C.; Lother, A.; Salzer, U.; Bildl, W.; Welsink, T.; Morgenthaler, N.; Busse Grawitz, A.; Huzly, D.; Schwemmle, M.; Hengel, H.; Falcone, V.
10.1101/2021.06.25.449893 — immunology — Posted on 2021-06-25
604 A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: Synthesis and preclinical characterization of SDM-16
Zheng, C.; Holden, D.; Zheng, M.-Q.; Pracitto, R.; Wilcox, K. C.; Lindemann, M.; Felchner, Z.; Zhang, L.; Tong, J.; Fowles, K.; Finnema, S. J.; Nabulsi, N.; Carson, R. E.; Huang, Y.; Cai, Z.
10.1101/2021.06.25.449978 — neuroscience — Posted on 2021-06-25
605 Sex Differences in Cerebral Edema after Experimental Traumatic Brain Injury
Minchew, H. M.; Christian, S. K.; Keselman, P.; Hu, J.; Andrews, B. T.; Harris, J. L.
10.1101/2021.06.25.449932 — neuroscience — Posted on 2021-06-25
606 FMRP regulates experience-dependent maturation of callosal synaptic connections and bilateral cortical synchrony
Zhang, Z.; Rumschlag, J.; Jonak, C. R.; Binder, D. K.; Razak, K. A.; Gibson, J. R.; Huber, K. M.
10.1101/2021.06.25.449490 — neuroscience — Posted on 2021-06-25
608 Single cell multi-omics analysis of chromothriptic medulloblastoma highlights genomic and transcriptomic consequences of genome instability
Parra, R. G.; Przybilla, M. J.; Simovic, M.; Susak, H.; Ratnaparkhe, M.; Wong, J. K.; Koerber, V.; Mallm, P.; Sill, M.; Kolb, T.; Kumar, R.; Casiraghi, N.; Ghasemi, D. R.; Maass, K. K.; Pajtler, K. W.; Jauch, A.; Korshunov, A.; Hoefer, T.; Zapatka, M.; Pfister, S. M.; Stegle, O.; Ernst, A.
10.1101/2021.06.25.449944 — cancer biology — Posted on 2021-06-25
611 Mitogen Kinase Kinase (MKK7) controls cytokine production in vitro and in vivo in mice
Caliz, A. D.; Yoo, H.-J.; Vertii, A.; Tournier, C.; Davis, R. J.; Keaney, J. F.; Kant, S.
10.1101/2021.06.25.449967 — biochemistry — Posted on 2021-06-25
614 Impact of SNP microarray analysis of compromised DNA on kinship classification success in the context of investigative genetic genealogy
de Vries, J. H.; Kling, D.; Vidaki, A.; Arp, P.; Kalamara, V.; Verbiest, M. M. P. J.; Piniewska-Rog, D.; Parsons, T. J.; Uitterlinden, A. G.; Kayser, M.
10.1101/2021.06.25.449870 — genetics — Posted on 2021-06-25
616 IFT20 is critical for early chondrogenesis during endochondral ossification
Yamaguchi, H.; Kitami, M.; Uchima Koecklin, K. H.; He, L.; Wang, J.; Perrien, D. S.; Lagor, W. R.; Komatsu, Y.
10.1101/2021.06.25.449945 — developmental biology — Posted on 2021-06-25
617 Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome
Jardine, L.; Webb, S.; Goh, I.; Quiroga Londono, M.; Reynolds, G.; Mather, M.; Olabi, B.; Stephenson, E.; Botting, R. A.; Horsfall, D.; Engelbert, J.; Maunder, D.; Mende, N.; Murnane, C.; Dann, E.; McGrath, J.; King, H.; Kucinski, I.; Queen, R.; Carey, C. D.; Shrubsole, C.; Poyner, E.; Acres, M.; Jones, C.; Ness, T.; Coultard, R.; Elliot, N.; O'Byrne, S.; Haltalli, M. L.; Lawrence, J. E.; Lisgo, S.; Balogh, P.; Meyer, K. B.; Prigmore, E.; Ambridge, K.; Sarkin Jain, M.; Efremova, M.; Pickard, K.; Creasey, T.; Bacardit, J.; Henderson, D.; Coxhead, J.; Filby, A.; Hussain, R.; Dixon, D.; McDonald,
10.1101/2021.06.25.449771 — developmental biology — Posted on 2021-06-25
618 ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment
Steimle, J. D.; Kim, C.; Nadadur, R. D.; Wang, Z.; Hoffmann, A. D.; Hanson, E.; Kweon, J.; Sinha, T.; Choi, K.; Black, B. L.; Cunningham, J. M.; Ikegami, K.; Moskowitz, I. P.
10.1101/2021.06.25.449981 — developmental biology — Posted on 2021-06-25
626 Functional diversification gave rise to allelic specialization in a rice NLR immune receptor pair
De la Concepcion, J. C.; Benjumea, J. V.; Bialas, A.; Terauchi, R.; Kamoun, S.; Banfield, M. J.
10.1101/2021.06.25.449940 — plant biology — Posted on 2021-06-25
628 ROCK1 regulates insulin secretion from β-cells
Sung, B.-J.; Lim, S.-B.; Kim, J. H.; Yang, W.-M.; Kulkarni, R. N.; Kim, Y.-B.; Lee, M. K.
10.1101/2021.06.25.449947 — physiology — Posted on 2021-06-25
629 Multiplexed single-molecule analysis of human telomerase synthesizing DNA
Hentschel, J.; Choi, J.; Bagshaw, C. R.; Lapointe, C. P.; Wang, J.; Jansson, L. I.; Badstubner, M.; Puglisi, J. D.; Stone, M. D.
10.1101/2021.06.25.449954 — biophysics — Posted on 2021-06-25
630 Drug repurposing based on a Quantum-Inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2 including vitamin B12
Jimenez-Guardeno, J. M.; Ortega-Prieto, A. M.; Menendez Moreno, B.; Maguire, T. J. A.; Diaz Hernandez, J. I.; Diez Perez, J.; Zuckerman, M.; Mercadal Playa, A.; Cordero Deline, C.; Malim, M. H.; Martinez-Nunez, R. T.
10.1101/2021.06.25.449609 — microbiology — Posted on 2021-06-25
631 Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection
Patterson, B.; Francisco, E. B.; Yogendra, R.; Long, E.; Pise, A.; Rodrigues, H.; Hall, E.; Herrera, o.; Parikh, P.; Guevara-Coto, J.; Chang, X.; Sacha, J. B.; Rodriguez, R.; Mora, J.
10.1101/2021.06.25.449905 — immunology — Posted on 2021-06-25
633 Engineered chimeric T cell receptor fusion construct (TRuC)-expressing T cells prevent translational shutdown in SARS-CoV-2-infected cells
Godbole, I.; Ciminski, K.; Yousefi, O. S.; Pathan-Chhatbar, S.; Saltukoglu, D.; Vesper, N.; Salavei, P.; Strietz, J.; Gensch, N.; Reth, M.; Schwemmle, M.; Schamel, W. W.
10.1101/2021.06.25.449871 — bioengineering — Posted on 2021-06-25
634 Population structure and introgression among recently differentiated Drosophila melanogaster populations
Coughlan, J. M.; Dagilis, A.; Serrato-Capuchina, A.; Elias, H.; Peede, D.; Isbell, K.; Castillo, D. M.; Cooper, B. S.; Matute, D. R.
10.1101/2021.06.25.449842 — evolutionary biology — Posted on 2021-06-25
636 Cryo-EM structure of the transcription termination factor Rho from Mycobacterium tuberculosis reveals mechanism of resistance to bicyclomycin
Saridakis, E.; Vishwakarma, R.; Lai-Kee-Him, J.; Martin, K.; Simon, I.; Cohen-Gonsaud, M.; Coste, F.; Bron, P.; Margeat, E.; Boudvillain, M.
10.1101/2021.06.25.449899 — molecular biology — Posted on 2021-06-25
643 Discovery and visualization of uncharacterized drug-protein adducts using mass spectrometry.
Riffle, M.; Hoopmann, M. R.; Jaschob, D.; Zhong, G.; Moritz, R. L.; MacCoss, M. J.; Davis, T. N.; Isoherranen, N.; Zelter, A.
10.1101/2021.06.24.449838 — pharmacology and toxicology — Posted on 2021-06-25
644 Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors
Colom, B.; Herms, A.; Dentro, S.; King, C.; Sood, R.; Alcolea, M.; Fernandez-Antoran, D.; Ong, S. H.; Fowler, J. C.; Mahbubani, K.; Saeb-Parsy, K.; Gerstung, M.; Hall, B. A.; Jones, P.
10.1101/2021.06.25.449880 — cancer biology — Posted on 2021-06-25
645 Nde1 is Required for Heterochromatin Compaction and Stability in Neocortical Neurons
Chomiak, A. A.; Lowe, C. C.; Guo, Y.; Mcdaniel, D.; Pan, H.; Zhou, X.; Zhou, Q.; Doughty, M. L.; Feng, Y.
10.1101/2021.06.25.449848 — genetics — Posted on 2021-06-25
646 Characterisation of the transcriptional dynamics underpinning the function, fate, and migration of the mouse Anterior Visceral Endoderm
Thowfeequ, S.; Fiorentino, J.; Hu, D.; Solovey, M.; Ruane, S.; Whitehead, M.; Vanhaesebroeck, B.; Scialdone, A.; Srinivas, S.
10.1101/2021.06.25.449902 — developmental biology — Posted on 2021-06-25
652 Prophages in the infant gut are largely induced, and may be functionally relevant to their hosts.
Redgwell, T. A.; Thorsen, J.; Petit, M.-A.; Deng, L.; Vestergaard, G. A.; Russel, J.; Bisgaard, H.; Nielsen, D. S.; Sorensen, S. J.; Stokholm, J.; Shah, S. A.
10.1101/2021.06.25.449885 — microbiology — Posted on 2021-06-25
653 Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state
Daniel, B.; Belk, J. A.; Meier, S. L.; Chen, A. Y.; Sandor, K.; Qi, Y.; Kitano, H.; Wheeler, J. R.; Foster, D. S.; Januszyk, M. S.; Longaker, M. T.; Chang, H. Y.; Satpathy, A. T.
10.1101/2021.06.24.449850 — immunology — Posted on 2021-06-25
654 Using dual EEG to analyse event-locked changes in child-adult neural connectivity
Marriott Haresign, I.; Phillips, E.; Whitehorn, M.; Goupil, L.; Wass, S. V.
10.1101/2021.06.15.448573 — neuroscience — Posted on 2021-06-25
655 Ketamine and sleep modulate neural complexity dynamics in cats
Pascovich, C.; Castro-Zaballa, S.; Mediano, P. A. M.; Bor, D.; Canales-Johnson, A.; Torterolo, P. D.; Bekinschtein, T. A.
10.1101/2021.06.25.449513 — neuroscience — Posted on 2021-06-25
656 Neural activity in human brainstem adapts to sound-level statistics
Herrmann, B.; Yasmin, S.; Araz, K.; Purcell, D. W.; Johnsrude, I. S.
10.1101/2021.06.24.449846 — neuroscience — Posted on 2021-06-25
657 SynapseJ: an automated, synapse identification macro for ImageJ
Moreno Manrique, J. F.; Voit, P. R.; Windsor, K. E.; Karla, A. R.; Rodriguez, S. R.; Beaudoin, G. M.
10.1101/2021.06.24.449851 — neuroscience — Posted on 2021-06-25
658 Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing
Pfeffer, T.; Keitel, C.; Kluger, D. S.; Keitel, A.; Russmann, A.; Thut, G.; Donner, T. H.; Gross, J.
10.1101/2021.06.25.449734 — neuroscience — Posted on 2021-06-25
659 Flexible encoding of objects and space in single cells of the dentate gyrus
GoodSmith, D.; Kim, S. H.; Puliyadi, V.; Ming, G.-l.; Song, H.; Knierim, J. J.; Christian, K. M.
10.1101/2021.06.25.449795 — neuroscience — Posted on 2021-06-25
663 Genomic miscellany and allelic frequencies of Plasmodium falciparum msp-1, msp-2 and glurp in parasite isolates
Shah, M.; Ullah, I.; Afridi, S. G.; Israr, M.; Khan, A.; Ali, A.; Jabeen, H.; Raasool, A.; Akbar, F.
10.1101/2021.06.25.449861 — zoology — Posted on 2021-06-25
668 Annealing synchronizes the 70S ribosome into a minimum-energy conformation
Chu, X.; Su, X.; Liu, M.; Li, L.; Li, T.; Qin, Y.; Lu, G.; Qi, L.; Liu, Y.; Lin, J.; Shen, Q.
10.1101/2021.06.25.447849 — biophysics — Posted on 2021-06-25
670 BayesDeBulk: A Flexible Bayesian Algorithm for the Deconvolution of Bulk Tumor Data
Petralia, F.; Calinawan, A. P.; Feng, S.; Gosline, S. J.; Pugliese, P.; Ceccarelli, M.; Wang, P.
10.1101/2021.06.25.449763 — bioinformatics — Posted on 2021-06-25
672 c-di-GMP inhibits early sporulation in Clostridioides difficile
Edwards, A. N.; Williams, C. L.; Pareek, N.; McBride, S. M.; Tamayo, R.
10.1101/2021.06.24.449855 — microbiology — Posted on 2021-06-25
674 The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemia
Luciano, M.; Blöchl, C.; Vetter, J.; Urwanisch, L.; Neuper, T.; Elmer, D. P.; Bauer, R.; Dang, H.-H.; Strandt, H.; Neureiter, D.; Krenn, P.; Tesanovic, S.; Rieser, S.; Bergsleitner, O.; Zell, L.; Binder, S.; Schaller, S.; Strunk, D.; Pleyer, L.; Greil, R.; Winkler, S.; Hartmann, T. N.; Huber, C. G.; Aberger, F.; Horejs-Hoeck, J.
10.1101/2021.06.25.449862 — immunology — Posted on 2021-06-25
678 Unprecedented incidence of Trypanosoma cruzi infections in a cohort of dogs directly detected through longitudinal tracking at multi-dog kennels, Texas, USA
Busselman, R. E.; Meyers, A. C.; Zecca, I. B.; Auckland, L. D.; Castro, A. H.; Dowd, R. E.; Curtis-Robles, R.; Hodo, C. L.; Saunders, A. B.; Hamer, S. A.
10.1101/2021.06.24.449798 — zoology — Posted on 2021-06-25
679 Identification and characterization of novel proteins from Arizona bark scorpion venom that inhibit Nav1.8, a voltage-gated sodium channel regulator of pain signaling
Abd El-Aziz, T. M.; Xiao, Y.; Kline, J.; Gridley, H.; Heaston, A.; Linse, K. D.; Ward, M. J.; Rokyta, D. R.; Stockand, J. D.; Cummins, T. R.; Fornelli, L.; Rowe, A. H.
10.1101/2021.06.24.449822 — pharmacology and toxicology — Posted on 2021-06-25
681 Protection of the prodomain 1-helix correlates with latency in the transforming growth factor- family
Le, V. Q.; Zhao, B.; Iacob, R. E.; Tian, Y.; Toohey, C.; Engen, J. R.; Springer, T. A.
10.1101/2021.06.24.449816 — biophysics — Posted on 2021-06-25
683 Non-Newtonian Patient-specific Simulations of Left Atrial Hemodynamics
Gonzalo, A.; Garcia-Villalba, M.; Rossini, L.; Duran, E.; Vigneault, D.; Martinez-Legazpi, P.; Flores, O.; Bermejo, J.; McVeigh, E.; Kahn, A.; del Alamo, J. C.
10.1101/2021.06.24.449801 — bioengineering — Posted on 2021-06-25
684 Genetic evidence for environment-dependent hybrid incompatibilities in threespine stickleback
Thompson, K. A.; Peichel, C. L.; Rennison, D. J.; McGee, M. D.; Albert, A. Y. K.; Vines, T. H.; Greenwood, A. K.; Wark, A. R.; Brandvain, Y.; Schumer, M.; Schluter, D.
10.1101/2021.06.24.449805 — evolutionary biology — Posted on 2021-06-25
685 Macrosystem community assembly patterns are predicted by foundation tree species genetic connectivity and environment across the American Southwest
Bothwell, H. M.; Keith, A. R.; Hull, J. B.; Cooper, H. F.; Andrews, L. V.; Wehenkel, C.; Hultine, K. R.; Gehring, C. A.; Cushman, S. A.; Whitham, T. G.; Allan, G. J.
10.1101/2021.06.24.449837 — ecology — Posted on 2021-06-25
687 A novel flight style allowing the smallest featherwing beetles to excel
Farisenkov, S. E.; Kolomenskiy, D.; Petrov, P. N.; Lapina, N. A.; Engels, T.; Lehmann, F.-O.; Onishi, R.; Liu, H.; Polilov, A. A.
10.1101/2021.06.24.449497 — zoology — Posted on 2021-06-25
690 High affinity FcγR activating function depends on IRAP+ endosomal-signaling platforms
Benadda, S.; NUGUE, M.; BENS, M.; Monteiro, R.; Evnouchidou, I.; SAVEANU, L.
10.1101/2021.06.24.449774 — immunology — Posted on 2021-06-25
692 The PLETHORA/PIN-FORMED/AUXIN network mediates terminal prehaustorium formation in the parasitic plant Striga hermonthica
Xiao, T. T.; Kirschner, G. K.; Kountche, B. A.; Jamil, M.; Maria, S.; Lube, V.; Mironova, V.; Al Babili, S.; Blilou, I.
10.1101/2021.06.24.449531 — plant biology — Posted on 2021-06-25
695 The Forget-Me-Not dHCP study: 7 Tesla high resolution diffusion imaging in the unfixed post-mortem neonatal brain
Wu, W.; Baxter, L.; Rieger, S. W.; Adams, E.; Andersson, J. L. R.; Andrade, M. C.; Andritsou, F.; Bastiani, M.; Fry, R. E.; Frost, R.; Fitzgibbon, S.; Foxley, S.; Fowler, D.; Gallagher, C.; Howard, A. F.; Hajnal, J. V.; Moultrie, F.; Monk, V.; Porter, D. A.; Papp, D.; Price, A.; Sallet, J.; Sanders, M.; Wilkinson, D.; Smith, S. M.; Slater, R.; Miller, K. L.
10.1101/2021.06.24.449666 — bioengineering — Posted on 2021-06-25
696 Design and validation of a multi-point injection technology for MR-guided convection enhanced delivery in the brain
Prezelski, K.; Keiser, M.; Stein, J. M.; Lucas, T. H.; Davidson, B.; Gonzalez-Alegre, P.; Vitale, F.
10.1101/2021.06.24.449788 — bioengineering — Posted on 2021-06-25
697 Probing Neuro-Endocrine Interactions Through Wireless Magnetothermal Stimulation of Peripheral Organs
Maeng, L. Y.; Rosenfeld, D.; Simandl, G. J.; Koehler, F.; Senko, A.; Moon, J.; Varnavides, G.; Murillo, M. F.; Reimer, A. E.; Wald, A.; Anikeeva, P.; Widge, A. S.
10.1101/2021.06.24.449506 — bioengineering — Posted on 2021-06-25
698 Directed Evolution of AAV Targeting Primate Retina by Intravitreal Injection Identifies R100, a Variant Demonstrating Robust Gene Delivery and Therapeutic Efficacy in Non-Human Primates
Kotterman, M. A.; Beliakoff, G.; Croze, R.; Vazin, T.; Schmitt, C.; Szymanski, P.; Leong, M.; Quezada, M.; Holt, J.; Barglow, K.; Hassanipour, M.; Schaffer, D. V.; Francis, P.; Kirn, D. H.
10.1101/2021.06.24.449775 — bioengineering — Posted on 2021-06-25
700 A convolutional neural network for the quality control of MRI defacing
Delbarre, D. J.; Santos, L.; Ganjgahi, H.; Horner, N.; McCoy, A.; Westerberg, H.; Häring, D. A.; Nichols, T. E.; Mallon, A.-M.
10.1101/2021.06.24.449613 — neuroscience — Posted on 2021-06-25
707 Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates
Toth, A.; Steinmeyer, S.; Kannan, P. S.; Gray, J.; Jackson, C.; Mukherjee, S.; Demmert, M.; Sheak, J. R.; Benson, D.; Kitzmiller, J.; Wayman, J. A.; Presicce, P.; Cates, C.; Rubin, R.; Chetal, K.; Du, Y.; Miao, Y.; Guo, M.; Gu, M.; Kalinichenko, V. V.; Kallapur, S. G.; Miraldi, E. R.; Xu, Y.; Swarr, D. T.; Lewkowich, I.; Salomonis, N. T.; Miller, L.; Sucre, J.; Whitsett, J. A.; Chougnet, C.; Jobe, A. H.; Deshmukh, H.; Zacharias, W. J.
10.1101/2021.06.24.449766 — developmental biology — Posted on 2021-06-25
709 Ectosomes and exosomes are distinct proteomic entities that modulate spontaneous activity in neuronal cells
Bras, I. C.; Khani, M. H.; Riedel, D.; Parfentev, I.; Gerhardt, E.; van Riesen, C.; Urlaub, H.; Gollisch, T.; Outeiro, T. F.
10.1101/2021.06.24.449731 — neuroscience — Posted on 2021-06-25
712 Two evolutionary distinct effectors from a nematode and virus target RanGAP1 and 2 via the WPP domain to promote disease
Sukarta, O. C. A.; Munoz, A. D. G.; Slootweg, E. J.; Overmars, H.; van Schaik, C.; Pokhare, S.; Roosien, J.; Pomp, R.; Elashry, A.; Grundler, F.; Smant, G.; Goverse, A.
10.1101/2021.06.24.449730 — plant biology — Posted on 2021-06-25
713 Cellular transformation by combined lineage conversion and oncogene expression
Sahu, B.; Pihlajamaa, P.; Zhang, K.; Palin, K.; Ahonen, S.; Cervera, A.; Ristimaki, A.; Aaltonen, L.; Hautaniemi, S.; Taipale, J.
10.1101/525600 — cancer biology — Posted on 2021-06-25
716 Chemical mapping exposes the importance of active site interactions in governing the temperature dependence of enzyme turnover
Winter, S. D.; Jones, H. B.; Rasadean, D.; Crean, R.; Danson, M. J.; Pantos, D.; Katona, G.; Prentice, E.; Arcus, V.; van der kamp, M.; Pudney, C. R.
10.1101/2021.06.25.449875 — biochemistry — Posted on 2021-06-25
719 Antiviral activity of influenza A virus defective interfering particles against SARS-CoV-2 replication in vitro through stimulation of innate immunity
Rand, U.; Kupke, S. Y.; Shkarlet, H.; Hein, M. D.; Hirsch, T.; Marichal-Gallardo, P.; Cicin-Sain, L.; Reichl, U.; Bruder, D.
10.1101/2021.02.19.431972 — microbiology — Posted on 2021-06-25
722 Robust effects of corticothalamic feedback during naturalistic visual stimulation
Spacek, M. A.; Born, G.; Crombie, D.; Bauer, Y.; Liu, X.; Katzner, S.; Busse, L.
10.1101/776237 — neuroscience — Posted on 2021-06-25
723 PpRPK2 modulates auxin homeostasis and transport to specify stem cell identity and plant shape in the moss Physcomitrella
Nemec Venza, Z.; Madden, C.; Stewart, A.; Liu, W.; Novak, O.; Penik, A.; Cuming, A. C.; Kamisugi, Y.; Harrison, C. J.
10.1101/2021.06.24.449551 — plant biology — Posted on 2021-06-25
726 Membraneless organelles formed by liquid-liquid phase separation increase bacterial fitness
Jin, X.; Lee, J.-E.; Schaefer, C.; Luo, X.; Wollman, A. J.; Payne-Dwyer, A. L.; Tian, T.; Zhang, X.; Chen, X.; Li, Y.; Leake, M. C.; Bai, F. C.
10.1101/2021.06.24.449778 — biophysics — Posted on 2021-06-25
728 Identification of public submitted tick images: a neural network approach
Justen, L.; Carlsmith, D.; Paskewitz, S. M.; Bartholomay, L. C.; Bron, G. M.
10.1101/2021.06.24.449695 — bioinformatics — Posted on 2021-06-25
737 Fetal-like reversion in the regenerating intestine is regulated by mesenchymal Asporin
Iqbal, S.; Andersson, S.; Nestaite, E.; Pentinmikko, N.; Kumar, A.; Borshagovski, D.; Webb, A.; Saarinen, T.; Juuti, A.; Ori, A.; Varjosalo, M.; Pietiläinen, K. H.; Jensen, K. B.; Oudhoff, M.; Katajisto, P.
10.1101/2021.06.24.449590 — developmental biology — Posted on 2021-06-25
738 High viral abundance and low diversity are associated with increased CRISPR-Cas prevalence across microbial ecosystems
Meaden, S.; Biswas, A.; Arkhipova, K.; Morales, S. E.; Dutilh, B. E.; Westra, E. R.; Fineran, P. C.
10.1101/2021.06.24.449667 — microbiology — Posted on 2021-06-25
739 Cellular and molecular signatures of in vivo GABAergic neurotransmission in the human brain
Lukow, P. B.; Martins, D.; Veronese, M.; Vernon, A. C.; McGuire, P.; Turkheimer, F. E.; Modinos, G.
10.1101/2021.06.17.448812 — neuroscience — Posted on 2021-06-25
740 NEST Desktop - An educational application for neuroscience
Spreizer, S.; Senk, J.; Rotter, S.; Diesmann, M.; Weyers, B.
10.1101/2021.06.15.444791 — neuroscience — Posted on 2021-06-25
742 Neural indicators of human gut feelings
Mayeli, A.; Al Zoubi, O.; White, E. J.; Chappelle, S.; Kuplicki, R.; Smith, R.; Feinstein, J. S.; Bodurka, J.; Paulus, M. P.; Khalsa, S. S.
10.1101/2021.02.11.430867 — neuroscience — Posted on 2021-06-25
744 Field microenvironments regulate crop diel transcript and metabolite rhythms
Dantas, L. L. B.; Dourado, M. M.; de Lima, N. O.; Cavacana, N.; Nishiyama-Jr., M. Y.; Souza, G. M.; Carneiro, M. S.; Caldana, C.; Hotta, C. T.
10.1101/2021.04.08.439063 — plant biology — Posted on 2021-06-25
746 In vivo imaging and quantification of carbon tracer dynamics in nodulated root systems of pea plants
Metzner, R.; Chlubek, A.; Bühler, J.; Pflugfelder, D.; Schurr, U.; Huber, G.; Koller, R.; Jahnke, S.
10.1101/2021.06.23.449643 — plant biology — Posted on 2021-06-25
748 Rapid and reproducible MALDI-TOF-based method for detection Vancomycin-resistant Enterococcus faecium using classifying algorithms
Candela, A.; Arroyo, M. J.; Sanchez-Molleda, A.; Mendez, G.; Rodriguez-Temporal, D.; Quiroga, L.; Ruiz, A.; Cercenado, E.; Marin, M.; Munoz, P.; Mancera, L.; Rodriguez-Sanchez, B.
10.1101/2021.06.23.449689 — microbiology — Posted on 2021-06-25
751 Multivariate genome-wide association studies on the tissue compartments of human brain identify novel loci underpinning brain development and neuropsychiatric outcomes.
Fan, C. C.; Loughnan, R.; Pechva, D.; Chen, C.-H.; Hagler, D.; Thompson, W. K.; van der Meer, D.; Frei, O.; Andreassen, O.; Dale, A. M.
10.1101/2021.06.24.449723 — genetics — Posted on 2021-06-24
752 Cohesin is required for long-range enhancer action
Kane, L.; Williamson, I.; Flyamer, I. M.; Kumar, Y.; Hill, R. E.; Lettice, L. A.; Bickmore, W. A.
10.1101/2021.06.24.449812 — genetics — Posted on 2021-06-24
756 Motility control through an anti-activation mechanism in Agrobacterium tumefaciens
Alakavuklar, M. A.; Heckel, B. C.; Stoner, A. M.; Stembel, J. A.; Fuqua, C.
10.1101/2021.06.24.449765 — microbiology — Posted on 2021-06-24
762 Neural indicators of human gut feelings
Mayeli, A.; Al Zoubi, O.; White, E. J.; Chappelle, S.; Kuplicki, R.; Smith, R.; Feinstein, J. S.; Bodurka, J.; Paulus, M. P.; Khalsa, S. S.
10.1101/2021.02.11.430867 — neuroscience — Posted on 2021-06-25
763 Profile of basal cell carcinoma mutations and copy number alterations - focus on gene-associated noncoding variants
Nawrocka, P. M.; Galka-Marciniak, P.; Urbanek-Trzeciak, M. O.; M., I.; Szostak, N.; Philips, A.; Susok, L.; Sand, M.; Kozlowski, P.
10.1101/2021.06.24.449728 — cancer biology — Posted on 2021-06-24
764 Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity
Kouba, T.; Vogel, D.; Thorkelsson, S. R.; Quemin, E. R. J.; Williams, H. M.; Milewski, M.; Busch, C.; Guenther, S.; Gruenewald, K.; Rosenthal, M.; Cusack, S.
10.1101/2021.06.24.449696 — biochemistry — Posted on 2021-06-24
766 Multiple Causal Variants Underlie Genetic Associations in Humans
Abell, N. S.; DeGorter, M. K.; Gloudemans, M.; Greenwald, E.; Smith, K. S.; He, Z. S.; Montgomery, S. B.
10.1101/2021.05.24.445471 — genetics — Posted on 2021-06-24
767 A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ cells to diabetes recovery in zebrafish
Singh, S. P.; Chawla, P.; Hnatiuk, A.; Kamel, M.; Delgadillo Silva, L. F.; Spanjaard, B.; Eski, S. E.; Janjuha, S.; Olivares Chauvet, P.; Kayisoglu, O.; Rost, F.; Blasche, J.; Krankel, A.; Petzold, A.; Kurth, T.; Reinhardt, S.; Junker, J. P.; Ninov, N.
10.1101/2021.06.24.449704 — developmental biology — Posted on 2021-06-24
768 Persistent DNA damage rewires lipid metabolism and promotes histone hyperacetylation via MYS-1/Tip60.
Hamsanathan, S.; Anthonymuthu, T.; Mullet, S. J.; Han, S.; Shinglot, H.; Siefken, E.; Sims, A. A.; Sen, P.; Pepper, H. L.; Wendell, S. G.; Snyder, N. W.; Bayir, H.; Kagan, V. E.; Gurkar, A. U.
10.1101/2021.06.24.449832 — cell biology — Posted on 2021-06-24
770 Asymmetric peptidoglycan editing generates the curvature of predatory bacteria, optimizing invasion and replication within a spherical prey niche
Banks, E. J.; Valdivia-Delgado, M.; Biboy, J.; Wilson, A.; Cadby, I. T.; Vollmer, W.; Lambert, C.; Lovering, A. L.; Sockett, R. E.
10.1101/2021.06.24.449793 — microbiology — Posted on 2021-06-24
772 Engineered human induced pluripotent cells enable genetic code expansion in brain organoids
van Husen, L.; Katsori, A. M.; Meineke, B.; Tjernberg, L. O.; Schedin-Weiss, S.; Elsässer, S. J.
10.1101/2021.06.24.449576 — synthetic biology — Posted on 2021-06-24
773 Rational engineering of an erythropoietin fusion protein to treat hypoxia
Lee, J.; Vernet, A.; Gruber, N. G.; Kready, K. M.; Burrill, D. R.; Way, J. C.; Silver, P. A.
10.1101/2021.06.24.449789 — synthetic biology — Posted on 2021-06-24
775 In planta genome editing with CRISPR/Cas9 ribonucleoproteins
Kumagai, Y.; Liu, Y.; Hamada, H.; Luo, W.; Zhu, J.; Kuroki, M.; Nagira, Y.; Taoka, N.; Kato, E.; Imai, R.
10.1101/2021.06.24.449705 — plant biology — Posted on 2021-06-24
776 Synthesis and Structure Elucidation of the Human tRNA Nucleoside Mannosyl-Queuosine
Carell, T.; Hillmeier, M.; Wagner, M.; Ensfelder, T.; Korytiakova, E.; Thumbs, P.; Mueller, M.
10.1101/2021.06.24.449707 — biochemistry — Posted on 2021-06-24
777 Characterization of novel competitive inhibitors of P. falciparum cGMP-dependent protein kinase
Eck, T.; Laureano de Souza, M.; Bheemanoboina, R. R. Y.; Chakrasali, R.; Kreiss, T.; Siekierka, J. J.; Rotella, D. P.; Bhanot, P.; Goodey, N. M.
10.1101/2021.06.24.449800 — biochemistry — Posted on 2021-06-24
779 Protein Kinase C gamma Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition
Pilo, C. A.; Kornev, A. P.; Baffi, T. R.; Kunkel, M. T.; Huang, L.-C.; Longman, C.; Kannan, N. A.; Taylor, S. S.; Gorrie, G.; Newton, A. C.
10.1101/2021.06.24.449810 — biochemistry — Posted on 2021-06-24
781 Development and Validation of an LC-MS/MS Based Quantitative Assay for Marmoset Insulin
Goy, R. W.; Shrestha, H. K.; Ziegler, T. E.; Dukes, N. J.; Colman, R. J.; Kapoor, A.
10.1101/2021.06.24.449777 — biochemistry — Posted on 2021-06-24
782 The population genomics of increased virulence and antibiotic resistance in human commensal Escherichia coli over 30 years in France
Marin, J.; Clermont, O.; Royer, G.; Mercier-Darty, M.; Decousser, J.-W.; Tenaillon, O.; Denamur, E.; Blanquart, F.
10.1101/2021.06.24.449745 — genomics — Posted on 2021-06-24
783 LAP1 regulates nuclear plasticity to enable constrained migration
Jung Garcia, Y.; Maiques, O.; Rodriguez-Hernandez, I.; Fanshawe, B.; Domart, M.-C.; Renshaw, M. J.; Marti, R. M.; Matias-Guiu, X.; Collinson, L.; Sanz-Moreno, V.; Carlton, J. G.
10.1101/2021.06.23.449503 — cell biology — Posted on 2021-06-24
784 A δ-cell subpopulation with a pro-β-cell identity confers efficient age-independent recovery in a zebrafish model of diabetes
Carril Pardo, C. A.; Massoz, L.; Dupont, M.; Bergemann, D.; Bourdouxhe, J.; Lavergne, A.; Tarifeno-Saldivia, E.; Helker, C. S. M.; Stainier, D. Y. R.; Peers, B.; Voz, M. L.; Manfroid, I.
10.1101/2021.06.24.449706 — cell biology — Posted on 2021-06-24
787 CMTr cap-adjacent 2`-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses
Haussmann, I.; Wu, Y.; Nallasivan, M.; Archer, N.; Bodi, Z.; Hebenstreit, D.; Waddell, S.; Fray, R.; Soller, M.
10.1101/2021.06.24.449724 — molecular biology — Posted on 2021-06-24
788 Dynamically expressed ELAV is required for learning and memory in bees
Ustaoglu, P.; Kaur Gill, J.; Doubovetzky, N.; Haussmann, I.; Devaud, J.-M.; Soller, M.
10.1101/2021.06.24.449637 — molecular biology — Posted on 2021-06-24
790 Stress-induced cross-feeding of internal metabolites provides a dynamic mechanism of microbial cooperation
Amarnath, K.; Narla, A.; Pontrelli, S.; Dong, J.; Caglar, T.; Taylor, B. R.; Schwartzman, J. A.; Sauer, U.; Cordero, O. X.; Hwa, T.
10.1101/2021.06.24.449802 — microbiology — Posted on 2021-06-24
797 Why are SNAREpins rod-shaped?
Zeng, J.; McDargh, Z.; An, D.; O'Shaughnessy, B.
10.1101/2021.06.23.449668 — biophysics — Posted on 2021-06-24
798 Miniaturizing wet scrubbers for aerosolized droplet capture
Lee, U. N.; van Neel, T. L.; Lim, F. Y.; Khor, J. W.; He, J.; Vaddi, R. S.; Ong, A. Q.; Tang, A.; Berthier, J.; Meschke, J. S.; Novosselov, I. V.; Theberge, A. B.; Berthier, E.
10.1101/2021.03.23.436614 — bioengineering — Posted on 2021-06-24
802 Niche partitioning facilitates coexistence of closely related gut bacteria
Brochet, S.; Quinn, A.; Mars, R. A. T.; Neuschwander, N.; Sauer, U.; Engel, P.
10.1101/2021.03.12.434400 — microbiology — Posted on 2021-06-24
804 Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection
Schultz, D.; Johnson, R.; Ayyanathan, K.; Miller, J.; Whig, K.; Kamalia, B.; Dittmar, M.; Weston, S.; Hammond, H.; Dillen, C.; Castellana, L.; Lee, J. S.; Li, M.; Lee, E. M.; Constant, S.; Ferrer, M.; Thaiss, C.; Frieman, M.; Cherry, S.
10.1101/2021.06.24.449811 — microbiology — Posted on 2021-06-24
806 Narratives: fMRI data for evaluating models of naturalistic language comprehension
Nastase, S. A.; Liu, Y.-F.; Hillman, H.; Zadbood, A.; Hasenfratz, L.; Keshavarzian, N.; Chen, J.; Honey, C. J.; Yeshurun, Y.; Regev, M.; Nguyen, M.; Chang, C. H. C.; Baldassano, C.; Lositsky, O.; Simony, E.; Chow, M. A.; Leong, Y. C.; Brooks, P. P.; Micciche, E.; Choe, G.; Goldstein, A.; Vanderwal, T.; Halchenko, Y. O.; Norman, K. A.; Hasson, U.
10.1101/2020.12.23.424091 — neuroscience — Posted on 2021-06-24
808 Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components
Oliver, D.; Ramachandran, S.; Philbrook, A.; Lambert, C. M.; Nguyen, K. C. Q.; Hall, D. H.; Francis, M.
10.1101/2021.05.11.443328 — neuroscience — Posted on 2021-06-24
809 Influence of sensory modality and control dynamics on human path integration
Stavropoulos, A.; Lakshminarasimhan, K. J.; Laurens, J.; Pitkow, X.; Angelaki, D.
10.1101/2020.09.21.307256 — neuroscience — Posted on 2021-06-24
810 Cell fitness is an omniphenotype
Jacobs, N. C.; Park, J.; Saccone, N. L.; Peterson, T. R.
10.1101/487157 — systems biology — Posted on 2021-06-24
816 Quantitative sub-cellular acyl-CoA analysis reveals distinct nuclear regulation
Trefely, S.; Huber, K.; Liu, J.; Noji, M.; Stransky, S.; Singh, J.; Doan, M.; Lovell, C. D.; von Krusenstiern, E.; Jiang, H.; Bostwick, A.; Pepper, H. L.; Izzo, L.; Zhao, S.; Xu, J. P.; Bedi, K. C.; Rame, J. E.; Bogner-Strauss, J. G.; Mesaros, C.; Sidoli, S.; Wellen, K. E.; Snyder, N. W.
10.1101/2020.07.30.229468 — biochemistry — Posted on 2021-06-24
818 Genetic architecture of a mutation's expressivity
Schell, R.; Hale, J. J.; Mullis, M. N.; Matsui, T.; Foree, R.; Ehrenreich, I. M.
10.1101/2020.04.03.024547 — genetics — Posted on 2021-06-24
820 Chromatin dynamics during hematopoiesis reveal discrete regulatory modules instructing differentiation
Georgolopoulos, G.; Psatha, N.; Iwata, M.; Nishida, A.; Som, T.; Yiangou, M.; Stamatoyannopoulos, J. A.; Vierstra, J.
10.1101/2020.04.02.022566 — developmental biology — Posted on 2021-06-24
822 Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation
Fraser, B. J.; Beldar, S.; Seitova, A.; Hutchinson, A.; Mannar, D.; Li, Y.; Kwon, D.; Tan, R.; Wilson, R. P.; Leopold, K.; Subramaniam, S.; Halabelian, L.; Arrowsmith, C. H.; Benard, F.
10.1101/2021.06.23.449282 — biochemistry — Posted on 2021-06-24
823 Lipid and nucleocapsid N-protein accumulation in COVID-19 patient lung and infected cells
Grootemaat, A.; van der Niet, S.; Scholl, E. R.; Roos, E.; Schurink, B.; Bugiani, M.; Miller, S. E.; Larsen, P. W.; Pankras, J.; Reits, E. E.; van der Wel, N. N.
10.1101/2021.06.24.449252 — microbiology — Posted on 2021-06-24
824 SARS-CoV-2-Triggered Mast Cell Rapid Degranulation Induces Alveolar Epithelial Inflammation and Lung Injury
Wu, M.-L.; Liu, F.-L.; Sun, J.; Li, X.; He, X.-Y.; Zheng, H.-Y.; Pei, R.-J.; Sun, H.; Zhou, Y.-H.; Yan, Q.-H.; Wu, C.-X.; Chen, L.; Yu, G.-Y.; Chang, J.; Jin, X.; Zhao, J.; Chen, X.-W.; Zheng, Y.-T.; Wang, J.-H.
10.1101/2021.06.24.449680 — microbiology — Posted on 2021-06-24
825 Allicin inhibits SARS-CoV-2 replication and abrogates the antiviral host response in the Calu-3 proteome
Mösbauer, K.; Fritsch, V. N.; Adrian, L.; Bernhardt, J.; Gruhlke, M. C. H.; Slusarenko, A. J.; Niemeyer, D.; Antelmann, H.
10.1101/2021.05.15.444275 — microbiology — Posted on 2021-06-24
826 The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2
Cathcart, A. L.; Havenar-Daughton, C.; Lempp, F. A.; Ma, D.; Schmid, M.; Agostini, M. L.; Guarino, B.; Di iulio, J.; Rosen, L.; Tucker, H.; Dillen, J.; Subramanian, S.; Sloan, B.; Bianchi, S.; Wojcechowskyj, J.; Zhou, J.; Kaiser, H.; Chase, A.; Lauron, E.; Montiel-Ruiz, M.; Spreafico, R.; Noack, J.; Czudnochowski, N.; Sahakyan, A.; Pinto, D.; Saliba, C.; Delotta, E.; Park, A.; Cameroni, E.; Ledoux, S.; Werts, A.; Colas, C.; Soriaga, L.; Telenti, A.; Purcell, L. A.; Hwang, S.; Snell, G.; Virgin, H. W.; Corti, D.; Hebner, C. M.
10.1101/2021.03.09.434607 — immunology — Posted on 2021-06-24
828 MethodsJ2: A Software Tool to Improve Microscopy Methods Reporting
Ryan, J.; Pengo, T.; Rigano, A.; Montero-Llopis, P.; Itano, M. S.; Cameron, L.; Marques, G.; Strambio-De-Castillia, C.; Sanders, M. A.; Brown, C. M.
10.1101/2021.06.23.449674 — bioinformatics — Posted on 2021-06-24
829 Prefusion conformation of SARS-CoV-2 receptor-binding domain favors interactions with human receptor ACE2
Kumawat, N.; Tucs, A.; Bera, S.; N. Chuev, G.; Fedotova, M. V.; Tsuda, K.; Kruchinin, S. E.; Sljoka, A.; CHAKRABORTY, A.
10.1101/2021.04.22.441041 — bioinformatics — Posted on 2021-06-24
832 Chrysomycin A inhibits the topoisomerase I of Mycobacterium tuberculosis.
Muralikrishnan, B.; Edison, L. K.; Dusthackeer, A.; Reji, J. G.; Ramachandran, R.; Madhavan, A.; Ajay Kumar, R.
10.1101/2021.06.23.449690 — biochemistry — Posted on 2021-06-24
833 The population genomics of increased virulence and antibiotic resistance in human commensal Escherichia coli over 30 years in France
Marin, J.; Clermont, O.; Royer, G.; Mercier-Darty, M.; Decousser, J.-W.; Tenaillon, O.; Denamur, E.; Blanquart, F.
10.1101/2021.06.24.449745 — genomics — Posted on 2021-06-24
835 Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength
Kong, J.; Young, C. B.; Pusapati, G.; Espinoza, F. H.; Patel, C.; Beckert, F.; Ho, S.; Patel, B. B.; Gabriel, G. C.; Aravind, L.; Bazan, J. F.; Gunn, T.; Lo, C.; Rohatgi, R.
10.1101/2021.06.23.449683 — developmental biology — Posted on 2021-06-24
837 Single-cell dissection of live human hearts in ischemic heart disease and heart failure reveals cell-type-specific driver genes and pathways
Linna-Kuosmanen, S.; Schmauch, E.; Galani, K.; Boix, C. A.; Hou, L.; Örd, T.; Toropainen, A.; Stolze, L. K.; Meibalan, E.; Mantero, J. C.; Renfro, A.; Ojanen, J.; Agudelo, L. Z.; Hollmen, M.; Jalkanen, J.; Gunn, J.; Tavi, P.; Romanoski, C. E.; MacRae, C. A.; Kaikkonen, M. U.; Garcia-Cardena, G.; Kiviniemi, T.; Kellis, M.
10.1101/2021.06.23.449672 — molecular biology — Posted on 2021-06-24
838 Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection: AXL as a Therapeutic Target for COVID-19
Bohan, D.; Van Ert, H.; Ruggio, N.; Rogers, K. J.; Baddredine, M.; Briseno, J. A. A.; Rojas Chavez, R. A.; Gao, B.; Stokowy, T.; Christakou, E.; Micklem, D.; Gausdal, G.; Haim, H.; Minna, J.; Lorens, J. B.; Maury, W.
10.1101/2021.06.15.448419 — microbiology — Posted on 2021-06-24
846 Structural analysis of 3'UTRs in insect flaviviruses reveals novel determinant of sfRNA biogenesis and provides new insights into flavivirus evolution
Slonchak, A.; Parry, R.; Pullinger, B.; Sng, J. D. J.; Wang, X.; Buck, T. F.; Torres, F. J.; Harrison, J. J.; Colmant, A. M. G.; Hobson-Peters, J.; Hall, R. A.; Tuplin, A.; Khromykh, A. A.
10.1101/2021.06.23.449515 — microbiology — Posted on 2021-06-24
847 Prolonged and distributed processing of facial identity in the human brain
Stecher, R.; Muukkonen, I.; Salmela, V. R.; Rostalski, S.-M.; Ambrus, G. G.; Kovacs, G.
10.1101/2021.06.23.449599 — neuroscience — Posted on 2021-06-24
848 Dopamine Neurons Evaluate Natural Fluctuations in Performance Quality
Duffy, A.; Latimer, K. W.; Goldberg, J. H.; Fairhall, A. L.; Gadagkar, V.
10.1101/2021.06.23.449657 — neuroscience — Posted on 2021-06-24
850 Coordination games in cancer
Bayer, P.; Gatenby, R.; McDonald, P. H.; Duckett, D. R.; Stankova, K.; Brown, J. S.
10.1101/2021.06.22.449436 — cancer biology — Posted on 2021-06-24
853 A Random Forest Classifier for Protein-Protein Docking Models
Barradas-Bautista, D.; Cao, Z.; Vangone, A.; Oliva, R.; Cavallo, L.
10.1101/2021.06.23.449420 — bioinformatics — Posted on 2021-06-24
854 A Bayesian Multivariate Mixture Model for Spatial Transcriptomics Data
Allen, C.; Chang, Y.; Neelon, B.; Chang, W.; Kim, H.; Li, Z.; Ma, Q.; Chung, D.
10.1101/2021.06.23.449615 — bioinformatics — Posted on 2021-06-24
855 High Bandwidth Power Electronics and Magnetic Nanoparticles for Multichannel Magnetogenetic Neurostimulation
Wang, B.; Li, Z.; Sebesta, C. E.; Torres Hinojosa, D.; Zhang, Q.; Robinson, J. T.; Bao, G.; Peterchev, A. V.; Goetz, S. M.
10.1101/2021.06.23.447876 — bioengineering — Posted on 2021-06-24
856 Genetic Analyses of Epigenetic Predictors that Estimate Aging, Metabolic Traits, and Lifespan
Mozhui, K.; Lu, A.; Li, C. Z.; Haghani, A.; Sandoval-Sierra, J. V.; Williams, R. W.; Horvath, S.
10.1101/2021.06.23.449634 — genomics — Posted on 2021-06-24
857 Factors Driving DNA Methylation Variation in Human Blood
Bergstedt, J.; Azzou, S. A. K.; Tsuo, K.; Jaquaniello, A.; Urrutia, A.; Rotival, M.; Lin, D. T. S.; Macisaac, J. L.; Kobor, M. S.; Albert, M. L.; Duffy, D.; Patin, E.; Quintana-Murci, L.
10.1101/2021.06.23.449602 — genomics — Posted on 2021-06-24
859 Polygenic variation in sexual investment across an ephemerality gradient in Daphnia pulex
Barnard-Kubow, K. B.; Becker, D.; Murray, C. S.; Porter, R.; Gutierrez, G.; Erickson, P. A.; Nunez, J. C. B.; Voss, E.; Suryamohan, K.; Ratan, A.; Beckerman, A.; Bergland, A. O.
10.1101/2021.06.23.449662 — evolutionary biology — Posted on 2021-06-24
862 An Open-Source Modular Framework for Automated Pipetting and Imaging Applications
Ouyang, W.; Bowman, R.; Wang, H.; Bumke, K. E.; Collins, J. T.; Spjuth, O.; Carreras-Puigvert, J.; Diederich, B.
10.1101/2021.06.24.449732 — cell biology — Posted on 2021-06-24
863 Repertoire analyses reveal TCR sequence features that influence T cell fate
Lagattuta, K. A.; Kang, J. B.; Nathan, A.; Pauken, K. E.; Jonsson, A. H.; Rao, D. A.; Ishigaki, K.; Raychaudhuri, S.
10.1101/2021.06.23.449653 — immunology — Posted on 2021-06-24
864 Intracortical human recordings reveal intensity coding for the pain of others in the insula
Soyman, E.; Bruls, R.; Ioumpa, K.; Müller-Pinzler, L.; Gallo, S.; van Straaten, E. C. W.; Self, M. W.; Peters, J. C.; Possel, J. K.; Onuki, Y.; Baayen, J. C.; Idema, S.; Keysers, C.; Gazzola, V.
10.1101/2021.06.23.449371 — neuroscience — Posted on 2021-06-24
868 Why are SNAREpins rod-shaped?
Zeng, J.; McDargh, Z.; An, D.; O'Shaughnessy, B.
10.1101/2021.06.23.449668 — biophysics — Posted on 2021-06-24
871 3D UNet with GAN discriminator for robust localisation of the fetal brain and trunk in MRI with partial coverage of the fetal body
Uus, A.; Grigorescu, I.; van Poppel, M.; Hughes, E.; Steinweg, J.; Roberts, T.; Lloyd, D.; Pushparajah, K.; Deprez, M.
10.1101/2021.06.23.449574 — bioengineering — Posted on 2021-06-24
874 Genomic history and forensic characteristics of Sherpa highlanders on the Tibetan Plateau inferred from high-resolution genome-wide InDels and SNPs
Wang, M.; Du, W.; Tang, R.; Liu, Y.; Zou, X.; Yuan, D.; Wang, Z.; Liu, J.; Guo, J.; Yang, X.; Chen, J.; Yang, M.; Zhang, X.; Wei, L.-H.; Yuan, H.; Yeh, H.-Y.; Wang, C.-C.; Liu, C.; He, G.
10.1101/2021.06.23.449553 — genetics — Posted on 2021-06-24
875 Adaptive shifts underlie the divergence in wing morphology in bombycoid moths
Aiello, B. R.; Tan, M.; Bin Sikandar, U.; Alvey, A. J.; Bhinderwala, B.; Kimball, K.; Barber, J.; Hamilton, C. A.; Kawahara, A. Y.; Sponberg, S.
10.1101/2021.06.23.449655 — evolutionary biology — Posted on 2021-06-24
877 Norepinephrine activates β1-adrenergic receptors localized to the inner nuclear membrane in cortical astrocytes
Benton, K. C.; Wheeler, D. S.; Kurtoglu, B.; Ansari, M. B. Z.; Cibich, D. P.; Gonzalez, D. A.; Herbst, M. R.; Khursheed, S.; Knorr, R. C.; Lobner, D.; Maglasang, J. G.; Rohr, K. E.; Taylor, A.; Witt, P. J.; Gasser, P. J.
10.1101/2021.06.24.446972 — cell biology — Posted on 2021-06-24
878 Moving Beyond the 'CAP' of the Iceberg: Intrinsic Connectivity Networks in fMRI are Continuously Engaging and Overlapping
Iraji, A.; Faghiri, A.; Fu, Z.; Kochunov, P.; Adhikari, B. M.; Belger, A.; Ford, J. M.; McEwen, S.; Mathalon, D. H.; Pearlson, G. D.; Potkin, S. G.; Preda, A.; Turner, J. A.; Van Erp, T. G. M.; Chang, C.; Calhoun, V. D.
10.1101/2021.06.23.449485 — neuroscience — Posted on 2021-06-24
879 OsciDrop: A versatile on-demand droplet generator
Ye, S.; Zheng, X.; Li, C.; Huang, W.; Tao, Y.; Yu, Y.; Yang, L.; Lan, Y.; Ma, L.; Bian, S.; Du, W.
10.1101/2021.06.14.448273 — bioengineering — Posted on 2021-06-24
880 Rate-of-change analysis in palaeoecology revisited: a new approach
Mottl, O.; Grytes, J.-A.; Seddon, A. W. R.; Steinbauer, M. J.; Bhatta, K. P.; Felde, V. A.; Flantua, S. G. A.; Birks, H. J. B.
10.1101/2020.12.16.422943 — ecology — Posted on 2021-06-24
881 Long-term patterns of an interconnected core marine microbiota
Krabberod, A. K.; Deutschmann, I. M.; Bjorbaekmo, M. F. M.; Balague, V.; Giner, C. R.; Ferrera, I.; Garces, E.; Massana, R.; Gasol, J. M.; Logares, R.
10.1101/2021.03.18.435965 — ecology — Posted on 2021-06-24
882 Egress of human cytomegalovirus through multivesicular bodies
Flomm, F. J.; Soh, T. K.; Schneider, C.; Britt, H. M.; Thalassinos, K.; Pfitzner, S.; Reimer, R.; Gruenewald, K.; Bosse, J. B.
10.1101/2020.12.31.424954 — microbiology — Posted on 2021-06-24
884 P2Y6 receptor signaling in natural killer cells impairs insulin sensitivity in obesity
Sieben, A.; Hausen, A. C.; Klemm, P.; Jais, A.; Heilinger, C.; Alber, J.; Folz-Donahue, K.; Schumacher, L.; Altmüller, J.; Franitza, M.; Giavalisco, P.; Hinze, Y.; Brodesser, S.; Kukat, C.; Theurich, S.; Brüning, J. C.
10.1101/2021.06.23.449596 — immunology — Posted on 2021-06-24
886 Alpha activity neuromodulation induced by individual alpha-based neurofeedback learning in ecological context: A double-blind randomized study
Grosselin, F.; Breton, A.; Yahia-Cherif, L.; Wang, X.; Spinelli, G.; Hugueville, L.; Fossati, P.; Attal, Y.; Navarro, X.; Chavez, M.; George, N.
10.1101/2020.12.02.406173 — neuroscience — Posted on 2021-06-24
887 Individual variation in brain microstructural-cognition relationships in aging
Patel, R.; Mackay, C. E.; Jansen, M. G.; Devenyi, G.; O'Donoghue, M. C.; Kivimäki, M.; Singh-Manoux, A.; Zsoldos, E.; Ebmeier, K. P.; Chakravarty, M.; Suri, S.
10.1101/2021.02.19.431732 — neuroscience — Posted on 2021-06-24
889 The structural connectome constrains fast brain dynamics
Sorrentino, P.; Seguin, C.; Rucco, R.; Liparoti, M.; Troisi Lopez, E.; Bonavita, S.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.; Zalesky, A.
10.1101/2020.11.25.393017 — neuroscience — Posted on 2021-06-24
892 Phenotypic melanoma heterogeneity is regulated through cell-matrix interaction-dependent changes in tumor microarchitecture
Spoerri, L.; Tonnessen-Murray, C. A.; Gunasingh, G.; Hill, D. S.; Beaumont, K. A.; Jurek, R. J.; Chauhan, J.; Vanwalleghem, G. C.; Fane, M. E.; Daignault-Mill, S. M.; Matigian, N.; Boyle, G. M.; Scott, E. K.; Smith, A. G.; Stehbens, S. J.; Schaider, H.; Gabrielli, B.; Weninger, W.; Goding, C. R.; Haass, N. K.
10.1101/2020.06.09.141747 — cancer biology — Posted on 2021-06-24
896 Timed global reorganization of protein synthesis during neocortex neurogenesis at codon resolution
Harnett, D.; Ambrozkiewicz, M. C.; Zinnall, U.; Borisova, E.; Rusanova, A.; Dannenberg, R.; Imami, K.; Muenster-Wandowski, A.; Fauler, B.; Mielke, T.; Selbach, M.; Landthaler, M.; Spahn, C. M. T.; Tarabykin, V.; Ohler, U.; Kraushar, M. L.
10.1101/2021.06.23.449626 — neuroscience — Posted on 2021-06-24
898 Clones and Clusters of Antimicrobial-Resistant Klebsiella from Southwestern Nigeria
Afolayan, A. O.; Oaikhena, A. O.; Aboderin, A. O.; Olabisi, O. F.; Amupitan, A. A.; Abiri, O. V.; Ogunleye, V. O.; Odih, E. E.; Adeyemo, A. T.; Adeyemo, A. T.; Obadare, T. O.; Abrudan, M.; Argimon, S.; David, S.; Kekre, M.; Underwood, A.; Egwuenu, A.; Ihekweazu, C.; Aanensen, D. M.; Okeke, I. N.; The NIHR Global Health Research Unit (GHRU) on Genomic Surveillance of Antimicrobial Resistance,
10.1101/2021.06.21.449255 — genomics — Posted on 2021-06-24
900 Uncovering the Genetic Profiles Underlying the Intrinsic Organization of the Human Cerebellum
Wang, Y.; Chai, L.; Li, D.; Gao, C.; Chu, C.; Yang, Z.; Zhang, Y.; Xu, J.; Nyengaard, J. R.; Liu, B.; Madsen, K. H.; Jiang, T.; Fan, L.
10.1101/2021.06.23.448673 — neuroscience — Posted on 2021-06-24
903 Transcriptional and Functional Activity of Hemangiosarcoma Support Bone Marrow Nurse Cell Ontogeny
Kim, J. H.; Schulte, A. J.; Sarver, A. L.; Angelos, M. G.; Frantz, A. M.; Foster, C. L.; O'Brien, T. D.; Cornax, I.; O'Sullivan, M. G.; Cheng, N.; Lewellen, M.; Oseth, L.; Kumar, S.; Bullman, S.; Pedamallu, C. S.; Goyal, S. M.; Meyerson, M.; Lund, T. C.; Alfoldi, J.; Lindblad-Toh, K.; Breen, M.; Dickerson, E. B.; Kaufman, D. S.; Modiano, J. F.
10.1101/2021.05.21.445198 — cancer biology — Posted on 2021-06-23
906 Complexity of genomic epidemiology of carbapenem-resistant Klebsiella pneumoniae isolates in Colombia urges the reinforcement of whole genome sequencing based surveillance programs
Saavedra, S. Y.; Bernal, J. F.; Escudero, E. M.; Arevalo, S. A.; Prada, D. A.; Valencia, M. F.; Moreno, J.; Hidalgo, A. M.; Abrudan, M.; Argimon, S.; Kekre, M.; Underwood, A.; Aanensen, D. M.; Duarte, C.; Donado-Godoy, P.; The NIHR Global Health Research Unit (GHRU) on Genomic Surveillance of Antimicrobial Resistance,
10.1101/2021.06.21.449250 — genomics — Posted on 2021-06-24
907 Mapping the microbial diversity and natural resistome of North Antarctica soils
Marcoleta, A. E.; Varas, M. A.; Costa, J.; Rojas-Salgado, J.; Arros, P.; Berrios Pasten, C.; Tapia, S.; Silva, D.; Fierro, J.; Canales, N.; Chavez, F. P.; Gaete, A.; Gonzalez, M.; Allende, M. L.; Lagos, R.
10.1101/2021.05.05.442734 — microbiology — Posted on 2021-06-23
908 A Drug-free, Self-destruction Strategy to Combat Bacterial Infections by Using the Intrinsically formed Magnetic Nanoparticles in Bacterial Pathogens
Ghosh, D.; Kaushik, S.; Thomas, J.; Panwar, V.; Murugesan, P.; Chopra, V.; Salaria, N.; Singh, R.; Roy, H. S.; Kumar, R.; Gautam, V.
10.1101/2021.02.03.429514 — microbiology — Posted on 2021-06-23
910 Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity
Loreto, A.; Angeletti, C.; Gu, W.; Osborne, A.; Nieuwenhuis, B.; Gilley, J.; Arthur-Farraj, P.; Merlini, E.; Amici, A.; Luo, Z.; Hartley-Tassell, L.; Ve, T.; Desrochers, L. M.; Wang, Q.; Kobe, B.; Orsomando, G.; Coleman, M. P.
10.1101/2020.09.18.304261 — neuroscience — Posted on 2021-06-23
911 Tight junction ZO proteins maintain tissue fluidity, ensuring efficient collective cell migration
Skamrahl, M.; Pang, H.; Ferle, M.; Gottwald, J.; Ruebeling, A.; Maraspini, R.; Honigmann, A.; Oswald, T. A.; Janshoff, A.
10.1101/2021.03.10.434539 — biophysics — Posted on 2021-06-23
915 Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis
Vu, T.; Vallmitjana, A.; Gu, J.; La, K.; Xu, Q.; Flores, J.; Zimak, J.; Shiu, J.; Hosohama, L.; Wu, J.; Douglas, C. R.; Waterman, M.; Ganesan, A.; Hedde, P. N.; Gratton, E.; Zhao, W.
10.1101/2021.06.22.449468 — bioengineering — Posted on 2021-06-23
916 Automating UbiFast for High-throughput and Multiplexed Ubiquitin Enrichment
Rivera, K. D.; Olive, M. E.; Bergstrom, E. J.; Nelson, A. J.; Lee, K. A.; Satpathy, S.; Carr, S. A.; Udeshi, N. D.
10.1101/2021.04.28.441860 — biochemistry — Posted on 2021-06-23
919 Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen
Murray, G.; Balmer, A. J.; Herbert, J.; Hadijirn, N. F.; Kemp, C. L.; Matuszewska, M.; Bruchmann, S.; Hossain, A. S. M. M.; Gottschalk, M.; Tucker, A. W.; Miller, E.; Weinert, L. A.
10.1101/2021.04.12.439332 — evolutionary biology — Posted on 2021-06-23
925 Gene exchange networks define species-like units in marine prokaryotes
Stepanauskas, R.; Brown, J. M.; Mai, U.; Bezuidt, O.; Pachiadaki, M.; Brown, J.; Biller, S.; Berube, P. M.; Record, N. R.; Mirarab, S.
10.1101/2020.09.10.291518 — microbiology — Posted on 2021-06-23
927 mRNA-decapping associated DcpS enzyme controls critical steps of neuronal development
Salamon, I.; Palsule, G.; Luo, X.; Roque, A.; Tucai, S.; Khosla, I.; Volk, N.; Liu, W.; Cui, H.; Dal Pozzo, V.; Zalamea, P.; Jiao, X.; DArcangelo, G.; Hart, R. P.; Rasin, M.-R.; Kiledjian, M.
10.1101/2021.05.10.443481 — neuroscience — Posted on 2021-06-23
928 The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects
Lambert, E.; Saha, O.; Soares Landeira, B.; Melo de Farias, A. R.; Hermant, X.; Carrier, A.; Pelletier, A.; Davoine, L.; Dupont, C.; Amouyel, P.; Bonnefond, A.; Lafont, F.; Abdelfettah, F.; Verstreken, P.; Chapuis, J.; Barois, N.; Delahaye, F.; Dermaut, B.; Lambert, J.-C.; Costa, M. R.; Dourlen, P.
10.1101/2021.04.02.438184 — neuroscience — Posted on 2021-06-23
929 Geometry of inter-areal interactions in mouse visual cortex
Iyer, R.; Siegle, J. H.; Mahalingam, G.; Olsen, S.; Mihalas, S.
10.1101/2021.06.09.447638 — neuroscience — Posted on 2021-06-23
931 Regulatory signatures of drought response in stress resilient Sorghum bicolor
Parvathaneni, R. K.; Kumar, I.; Braud, M.; Ozersky, P.; Mockler, T. C.; Eveland, A. L.
10.1101/2020.08.07.240580 — plant biology — Posted on 2021-06-23
933 Liver Endothelium Promotes HER3-mediated Cell Survival in KRAS Wild-type and Mutant Colorectal Cancer Cells
Rathore, M.; Wright, M.; Bhattacharya, R.; Fan, F.; Vaziri-Gohar, A.; Winter, J.; Wang, Z.; Markowitz, S.; Willis, J.; Ellis, L.; Wang, R.
10.1101/2021.04.27.441690 — cancer biology — Posted on 2021-06-23
940 The transcriptome of rat hippocampal subfields
Machado, J. P. D.; Athie, M. C. P.; Matos, A. H. B.; Lopes-Cendes, I.; Schwambach Vieira, A.
10.1101/2021.06.23.449669 — neuroscience — Posted on 2021-06-23
949 A TREM2-derived circRNA is upregulated in the entorhinal cortex of Alzheimer's disease patients
Urdanoz-Casado, A.; Sanchez-Ruiz de Gordoa, J.; Robles, M.; Roldan, M.; Zelaya, M. V.; Blanco-Luquin, I.; Mendioroz, M.
10.1101/2021.06.23.449571 — genetics — Posted on 2021-06-23
951 Dystrophin regulates peripheral circadian SRF signalling
Betts, C. A.; Jagannath, A.; van Westering, T.; Bowerman, M.; Banerjee, S.; Meng, J.; Falzarano, M. S.; Cravo, L.; McClorey, G.; Meijboom, K.; Bhomra, A.; Lim, C.; Rinaldi, C.; Counsell, J.; Chwalenia, K.; O'Donovan, E.; Saleh, A.; Gait, M. J.; Morgan, J.; Ferlini, A.; Foster, R.; Wood, M.
10.1101/2021.06.23.449492 — cell biology — Posted on 2021-06-23
954 LAP1 regulates nuclear plasticity to enable constrained migration
Jung Garcia, Y.; Maiques, O.; Rodriguez-Hernandez, I.; Fanshawe, B.; Domart, M.-C.; Renshaw, M. J.; Marti, R. M.; Matias-Guiu, X.; Collinson, L.; Sanz-Moreno, V.; Carlton, J. G.
10.1101/2021.06.23.449503 — cell biology — Posted on 2021-06-23
956 Rapid label-free identification of pathogenic bacteria species from a minute quantity 1 exploiting three-dimensional quantitative phase imaging and artificial neural network
Kim, G.; Ahn, D.; Kang, M.; Park, J.; Ryu, D.; Jo, Y.; Song, J.; Ryu, J. S.; Choi, G.; Chung, H. J.; Kim, K.; Chung, D. R.; Yoo, I. Y.; Huh, H. J.; Min, H.; Lee, N. Y.; Park, Y.
10.1101/596486 — microbiology — Posted on 2021-06-23
957 Ire1α-Regulated Rate of mRNA Translation is Required for Acquisition of Identity and Polarity in Upper Layer Cortical Neurons
Ambrozkiewicz, M. C.; Borisova, E.; Newman, A. G.; Kraushar, M. L.; Schaub, T.; Dannenberg, R.; Brockmann, M.; Rosario, M.; Turko, P.; Jahn, O.; Kaplan, D. R.; Iwawaki, T.; Spahn, C. M. T.; Rosenmund, C.; Tarabykin, V.
10.1101/2021.06.23.449563 — neuroscience — Posted on 2021-06-23
958 Neuronal hyperactivity in a LRRK2-G2019S cellular model of Parkinson's Disease
Lucumi Moreno, E.; Hachi, S.; Nickels, S. L.; Kane, K. I.; Moein, M.; Schwamborn, J. C.; Skupin, A.; Vanden Berghe, P.; Fleming, R. M.
10.1101/2021.06.23.449591 — neuroscience — Posted on 2021-06-23
959 Protein crosslinking as a therapeutic strategy for SOD1-related ALS
Hossain, M. A.; Sarin, R.; Donnelly, D. P.; Miller, B. C.; Salisbury, J. P.; Conway, J. B.; Watson, S.; Winters, J. N.; Alam, N.; Sivasankar, D.; Ponmudiyan, A. C.; Gawde, T.; Kannapadi, S.; Auclair, J. R.; Makowski, L.; Ringe, D.; Ondrechen, M. J.; Chen, Y.; Manetsch, R.; Agar, J. N.
10.1101/2021.06.23.449516 — neuroscience — Posted on 2021-06-23
960 Sustained TREM2 stabilization accelerates microglia heterogeneity and Abeta pathology in a mouse model of Alzheimer s disease
Dhandapani, R.; Neri, M.; Bernhard, M.; Brzak, I.; Schweizer, T.; Rudin, S.; Joller, S.; Berth, R.; Waldt, A.; Cuttat, R.; Naumann, U.; Gubser Keller, C.; Roma, G.; Feuerbach, D.; Shimshek, D. R.; Neumann, U.; Gasparini, F.; Galimberti, I.
10.1101/2021.06.23.449405 — neuroscience — Posted on 2021-06-23
965 Structural insight into molecular inhibitory mechanism of InsP6 on African Swine Fever Virus mRNA-decapping enzyme g5Rp
Yan, Y.; Zhang, C.; Li, L.; Li, X.; Yang, X.; Zhao, Y.; Chen, C.; Wang, W.; Zhong, Z.; Yang, C.; Huang, Z.; Su, D.
10.1101/2021.06.23.449648 — biochemistry — Posted on 2021-06-23
970 Increased lung cell entry of B.1.617.2 and evasion of antibodies induced by infection and BNT162b2 vaccination
Arora, P.; Krueger, N.; Kempf, A.; Nehlmeier, I.; Sidarovich, A.; Graichen, L.; Moldenhauer, A.-S.; Winkler, M. S.; Schulz, S.; Jaeck, H.-M.; Stankov, M. V.; Behrens, G. M. N.; Poehlmann, S.; Hoffmann, M.
10.1101/2021.06.23.449568 — molecular biology — Posted on 2021-06-23
971 Escherichia coli recombinant expression of SARS-CoV-2 protein fragments.
McGuire, B. E.; Mela, J. E.; Thompson, V. C.; Cucsksey, L. R.; Stevens, C. E.; McWhinnie, R. L.; Winkler, D. F.; Pelech, S.; Nano, F. E.
10.1101/2021.06.22.449540 — microbiology — Posted on 2021-06-23
972 SARS-CoV-2 neutralising antibodies in Dogs and Cats in the United Kingdom
Smith, S.; Anderson, E.; Cansado Utrilla, C.; Prince, T.; Farrell, S.; Brant, B.; Smyth, S.; Noble, P.-J.; Pinchbeck, G.; Marshall, N.; Roberts, L.; Hughes, G.; Radford, A.; Patterson, E. I.
10.1101/2021.06.23.449594 — microbiology — Posted on 2021-06-23
974 A selective adenylyl cyclase 1 inhibitor relieves pain without causing tolerance
Giacoletti, G.; Price, T.; Hoelz, L. V. B.; Shremo Msdi, A.; Vazquez-Falto, K.; Amorim Fernandes, T. V.; Santos de Pontes, V.; Wang, H.; Boechat, N.; Nornoo, A.; Brust, T.
10.1101/2021.06.23.448127 — pharmacology and toxicology — Posted on 2021-06-23
975 Phylodynamic assessment of control measures for highly pathogenic avian influenza epidemics in France
Chakraborty, D.; Guinat, C.; Müller, N. F.; Briand, F.-X.; Andraud, M.; Scoizec, A.; Lebouquin, S.; Niqueux, E.; Schmitz, A.; Grasland, B.; Guerin, J.-L.; Paul, M. C.; Vergne, T.
10.1101/2021.06.23.449570 — evolutionary biology — Posted on 2021-06-23
977 Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative
Malladi, S. K.; Patel, U. R.; Rajmani, R. S.; Singh, R.; Pandey, S.; Kumar, S.; Khaleeq, S.; Vuren, P. J. v.; Riddell, S. S.; Goldie, S.; Gayathri, S.; Chakraborty, D.; Kalita, P.; Pramanick, I.; Agarwal, N.; Reddy, P.; Girish, N.; Upadhyaya, A.; Khan, M. S.; Kanjo, K.; Bhat, M.; Mani, S.; Bhattacharyya, S.; Siddiqui, S.; Tyagi, A.; Jha, S.; Pandey, R.; Tripathi, S.; Dutta, S.; McAuley, A. J.; Singanallur, N. B.; Vasan, S. S.; Ringe, R. P.; Varadarajan, R.
10.1101/2021.01.13.426626 — microbiology — Posted on 2021-06-23
980 The role of population structure in computations through neural dynamics
Dubreuil, A. M.; Valente, A.; Beiran, M.; Mastrogiuseppe, F.; Ostojic, S.
10.1101/2020.07.03.185942 — neuroscience — Posted on 2021-06-23
981 INTRINSIC MOTOR NEURONE EXCITABILITY IS REDUCED IN SOLEUS AND TIBIALIS ANTERIOR OF OLDER ADULTS
Orssatto, L. B. R.; Borg, D. N.; Blazevich, A. J.; Sakugawa, R. L.; Shield, A. J.; Trajano, G. S.
10.1101/2021.06.23.449552 — physiology — Posted on 2021-06-23
982 Cross-platform Bayesian optimization system for autonomous biological assay development
Elder, S.; Klumpp-Thomas, C.; Yasgar, A.; Travers, J.; Frebert, S.; Wilson, K. M.; Zakharov, A. V.; Dahlin, J. L.; Kreisbeck, C.; Sheberla, D.; Sittampalam, G. S.; Godfrey, A. G.; Simeonov, A.; Michael, S.
10.1101/2021.06.23.448246 — biochemistry — Posted on 2021-06-23
983 Regulation of GTPase function by autophosphorylation
Johnson, C. W.; Seo, H.-S.; Terrell, E. M.; KleinJan, F.; Gebregiworgis, T.; Gasmi-Seabrook, G. M. C.; Geffken, E. A.; Lakhani, J.; Song, K.; Popow, O.; Paulo, J. A.; Liu, A.; Mattos, C.; Marshall, C. B.; Ikura, M.; Morrison, D. K.; Dhe-Paganon, S.; Haigis, K. M.
10.1101/2021.06.23.449327 — biochemistry — Posted on 2021-06-23
985 Bacterial response to spatial gradients of algal-derived nutrients in a porous microplate
Kim, H.; Kimbrel, J. A.; Vaiana, C. A.; Wollard, J. R.; Mayali, X.; Buie, C. R.
10.1101/2021.06.23.449330 — ecology — Posted on 2021-06-23
987 Parameter identifiability and model selection for sigmoid population growth models
Simpson, M. J.; Browning, A.; Warne, D. J.; Maclaren, O. J.; Baker, R. E.
10.1101/2021.06.22.449499 — ecology — Posted on 2021-06-23
989 Bifurcation drives the evolution of assembly-line biosynthesis
Booth, T. J.; Bozhüyük, K. A.; Liston, J. D.; Lacey, E.; Wilkinson, B.
10.1101/2021.06.23.449585 — microbiology — Posted on 2021-06-23
990 Fusobacterium nucleatum metabolically integrates commensals and pathogens in oral biofilms
Sakanaka, A.; Kuboniwa, M.; Shimma, S.; Alghamdi, S. A.; Mayumi, S.; Lamont, R. J.; Fukusaki, E.; Amano, A.
10.1101/2021.06.23.449328 — microbiology — Posted on 2021-06-23
997 Neuro-molecular characterization of fish cleaning interactions
Ramirez-Calero, S.; Paula, J. R.; Otjacques, E.; Rosa, R.; Ravasi, T.; Schunter, C.
10.1101/2021.06.22.449532 — animal behavior and cognition — Posted on 2021-06-23
998 Evidence for a bacterial Lands cycle phospholipase A: Structural and mechanistic insights into membrane phospholipid remodeling
Bleffert, F.; Granzin, J.; Caliskan, M.; Schott-Verdugo, S.; Siebers, M.; Thiele, B.; Rahme, L.; Felgner, S.; Doermann, P.; Gohlke, H.; Batra-Safferling, R.; Jaeger, K.-E.; Kovacic, F.
10.1101/2021.06.22.448587 — molecular biology — Posted on 2021-06-23
1001 A double-hit in vivo model of GBA1 viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration
Polissidis, A.; Nikolopoulou, G.; Koronaiou, E.; Nikatou, M.; Viel, C.; Bogiongko, M.; Sardi, S. P.; Xilouri, M.; Vekrellis, K.; Stefanis, L.
10.1101/2021.06.23.449545 — neuroscience — Posted on 2021-06-23
1006 Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis
Vu, T.; Vallmitjana, A.; Gu, J.; La, K.; Xu, Q.; Flores, J.; Zimak, J.; Shiu, J.; Hosohama, L.; Wu, J.; Douglas, C. R.; Waterman, M.; Ganesan, A.; Hedde, P. N.; Gratton, E.; Zhao, W.
10.1101/2021.06.22.449468 — bioengineering — Posted on 2021-06-23
1008 Genome instability drives epistatic adaptation in the human pathogen Leishmania
Bussotti, G.; Piel, L.; Pescher, P.; Domagalska, M. A.; Rajan, K. S.; Cohen-Chalamish, S.; Doniger, T.; Hiregange, D. G.; Myler, P. J.; Unger, R.; Michaeli, S. J.; Spaeth, G. F.
10.1101/2021.06.15.448517 — genomics — Posted on 2021-06-23
1019 A Multiparametric Activity Profiling Platform for Neuron Disease Phenotyping and Drug Screening
Boivin, B.; Roet, K. C. D.; Huang, X.; Karhohs, K. W.; Rohban, M. H.; Sandoe, J.; Wiskow, O.; Maeda, R.; Grantham, A.; Dornon, M. K.; Shao, J.; Frost, D.; Baker, D.; Eggan, K.; Carpenter, A. E.; Woolf, C. J.
10.1101/2021.06.22.449195 — neuroscience — Posted on 2021-06-23
1022 The Imaging and Molecular Annotation of Xenografts and Tumours (IMAXT) High Throughput Data and Analysis Infrastructure
Gonzalez-Solares, E. A.; Dariush, A.; Gonzalez-Fernandez, C.; Küpcü Yoldas, A.; Al Sa'd, M.; Millar, N.; Whitmarsh, T.; Chornay, N.; Falciatori, I.; Fatemi, A.; Goodwin, D.; Kuett, L.; Mulvey, C. M.; Paez Ribes, M.; Qosaj, F.; Roth, A.; Vazquez-Garcia, I.; Watson, S. S.; Windhager, J.; Aparicio, S.; Bodenmiller, B.; Boyden, E.; Caldas, C.; Harris, O.; Shah, S. P.; Tavare, S.; CRUK IMAXT Grand Challenge Team, ; Bressan, D.; Hannon, G. J.; Walton, N. A.
10.1101/2021.06.22.448403 — cancer biology — Posted on 2021-06-23
1024 CDK1 controls CHMP7-dependent nuclear envelope reformation
Gatta, A. T.; Olmos, Y.; Stoten, C. L.; Chen, Q.; Rosenthal, P. B.; Carlton, J. G.
10.1101/2020.04.20.050674 — cell biology — Posted on 2021-06-23
1026 Lactate is a major energy substrate for cortical neurons and enhances their firing activity.
Karagiannis, A.; Gallopin, T.; Lacroix, A.; Plaisier, F.; Piquet, J.; Geoffroy, H.; Hepp, R.; Naude, J.; Le Gac, B.; Egger, R.; Lambolez, B.; Li, D.; Rossier, J.; Staiger, J. F.; Imamura, H.; Seino, S.; Roeper, J.; Cauli, B.
10.1101/2021.05.17.444414 — neuroscience — Posted on 2021-06-23
1027 A multi-tiered map of EMT defines major transition points and identifies vulnerabilities
Paul, I.; Bolzan, D.; Youssef, A.; Gagnon, K. A.; Hook, H.; Karemore, G.; Oliphant, M. U.; Lin, W.; Liu, Q.; Phanse, S.; White, C.; Padhorny, D.; Kotelnikov, S.; Andrieu, G.; Chen, C. S.; Hu, P.; Denis, G. V.; Kozakov, D.; Raught, B.; Siggers, T.; Wuchty, S.; Muthuswamy, S.; Emili, A.
10.1101/2021.06.01.446492 — systems biology — Posted on 2021-06-23
1028 High-Resolution Genomic Profiling of Carbapenem-Resistant Klebsiella pneumoniae Isolates: A Multicentric Retrospective Indian Study
Nagaraj, G.; Ravikumar, K.; Govindan, V.; Shamanna, V.; Rose, S.; Sravani, D.; Akshatha, K. P.; M R, S.; Venkatesha, V. T.; Abrudan, M.; Argimon, S.; Kekre, M.; Underwood, A.; Aanensen, D.; The NIHR Global Health Research Unit (GHRU) on Genomic Surveillance of Antimicrobial Resistance,
10.1101/2021.06.21.449240 — genomics — Posted on 2021-06-23
1029 A cattle graph genome incorporating global breed diversity
Talenti, A.; Powell, J.; Hemmink, J. D.; Cook, E. A.; Wragg, D.; Jayaraman, S.; Paxton, E.; Ezeasor, C.; Obishakin, E. T.; Agusi, E. R.; Tijjani, A.; Marshall, K.; Fisch, A.; Ferreira, B.; Qasim, A.; Chaudhry, U. N.; Wiener, P.; Toye, P.; Morrison, L. J.; Connelley, T.; Prendergast, J.
10.1101/2021.06.23.449389 — genomics — Posted on 2021-06-23
1030 Horizontal transfer and southern migration: the tale of Hydrophiinae's marine journey.
Galbraith, J. D.; Ludington, A. J.; Edwards, R. J.; Sanders, K. L.; Suh, A.; Adelson, D. L.
10.1101/2021.06.22.449521 — evolutionary biology — Posted on 2021-06-23
1031 Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins
Emmenegger, M.; Kumar, S. S.; Emmenegger, V.; Buettner, T.; Schierack, P.; Sprinzl, M. F.; Sommer, C.; Lackner, K.; Aguzzi, A.; Roggenbuck, D.; Frauenknecht, K. B. M.
10.1101/2021.06.21.449211 — immunology — Posted on 2021-06-23
1032 EEG-Based Focus Estimation Using Neurable's Enten Headphones and Analytics Platform
Alcaide, R.; Agarwal, N.; Candassamy, J.; Cavanagh, S.; Lim, M.; Meschede-Krasa, B.; McIntyre, J.; Ruiz Blondet, M. V.; Siebert, B.; Stanley, D.; Valeriani, D.; Yousefi, A.
10.1101/2021.06.21.448991 — neuroscience — Posted on 2021-06-23
1033 Mapping lignification dynamics with a combination of chemistry, data segmentation and ratiometric analysis
Morel, O.; Lion, C.; Neutelings, G.; Stefanov, J.; Baldacci, F.; Simon, C.; Gierlinger, N.; Biot, C.; Hawkins, S.; Spriet, C.
10.1101/2021.06.21.449296 — plant biology — Posted on 2021-06-23
1035 Rapid Genomic Characterization and Global Surveillance of Klebsiella Using Pathogenwatch
Argimon, S.; David, S.; Underwood, A.; Abrudan, M.; Wheeler, N. E.; Kekre, M.; Abudahab, K.; Yeats, C. A.; Goater, R.; Taylor, B.; Harste, H.; Muddyman, D.; Feil, E. J.; Brisse, S.; Holt, K.; Donado-Godoy, P.; Ravikumar, K. L.; Okeke, I. N.; Carlos, C. C.; Aanensen, D. M.; The NIHR Global Health Research Unit for the Genomic Surveillance of Antimicrobial Resistance,
10.1101/2021.06.22.448967 — genomics — Posted on 2021-06-23
1037 A multimodal iPSC platform for cystic fibrosis drug testing
Berical, A.; Lee, R.; Lu, J.; Beermann, M. L.; LeSuer, J.; Mithal, A.; Thomas, D.; Ranallo, N.; Peasley, M.; Stuffer, A.; Harrington, J.; Coote, K.; Hurley, K.; McNally, P.; Mostoslavsky, G.; Mahoney, J.; Randell, S. H.; Hawkins, F. J.
10.1101/2021.06.21.448578 — developmental biology — Posted on 2021-06-23
1041 Forward genetics combined with unsupervised classifications identified zebrafish mutants affecting biliary system formation.
Singh, D. J.; Tuscano, K. M.; Ortega, K. L.; Dimri, M.; Tae, K.; Lee, W.; Muslim, M. A.; Liu, J. L.; Pierce, L. X.; McClendon, A.; Naegele, G.; Gibson, I.; Livesay, J.; Sakaguchi, T. F.
10.1101/2021.06.22.449425 — genetics — Posted on 2021-06-23
1044 Why Environmental Biomarkers Work: Transcriptome-Proteome Correlations and Modeling of Multi-Stressor Experiments in the Marine Bacterium Trichodesmium
Walworth, N. G.; Saito, M.; Lee, M. D.; McIlvin, M. R.; Moran, D. M.; Kellogg, R. M.; Fu, F.-X.; Hutchins, D. A.; Webb, E. A.
10.1101/2021.06.22.449505 — microbiology — Posted on 2021-06-23
1046 Cellular and molecular signatures of in vivo GABAergic neurotransmission in the human brain
Lukow, P. B.; Martins, D.; Veronese, M.; Vernon, A. C.; McGuire, P.; Turkheimer, F. E.; Modinos, G.
10.1101/2021.06.17.448812 — neuroscience — Posted on 2021-06-23
1047 Computational Fluid Dynamics Modeling of Cough Transport in an Aircraft Cabin
Zee, M.; Davis, A. C.; Clark, A. D.; Wu, T.; Jones, S. P.; Waite, L. L.; Cummins, J. J.; Olson, N. A.
10.1101/2021.02.15.431324 — biophysics — Posted on 2021-06-23
1048 Genomic sequence characteristics and the empiric accuracy of short-read sequencing
Marin, M. G.; Vargas, R.; Harris, M.; Jeffrey, B.; Epperson, L. E.; Durbin, D.; Strong, M.; Salfinger, M.; Iqbal, Z.; Akhundova, I.; Vashakidze, S.; Crudu, V.; Rosenthal, A.; Farhat, M. R.
10.1101/2021.04.08.438862 — bioinformatics — Posted on 2021-06-23
1049 Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade
Yagi-Utsumi, M.; Aoki, K.; Watanabe, H.; Song, C.; Nishimura, S.; Satoh, T.; Yanaka, S.; Ganser, C.; Tanaka, S.; Schnapka, V.; Goh, E. W.; Furutani, Y.; Murata, K.; Uchihashi, T.; Arakawa, K.; Kato, K.
10.1101/2021.06.22.449423 — biochemistry — Posted on 2021-06-23
1050 New insights from the combined discrimination of modern/ancient genome-wide shared alleles and haplotypes: Differentiated demographic history reconstruction of Tai-Kadai and Sinitic people in South China
Wang, M.; He, G.; Zou, X.; Chen, P.; Wang, Z.; Tang, R.; Yang, X.; Chen, J.; Yang, M.; Li, Y.; Liu, J.; Wang, F.; Zhao, J.; Guo, J.; Hu, R.; Wei, L.-H.; Chen, G.; Yeh, H.-Y.; Wang, C.-C.
10.1101/2021.06.19.449013 — genetics — Posted on 2021-06-23
1052 Competition is a determinant of multidrug resistant plasmid acquisition in Salmonella
Oladeinde, A.; Abdo, Z.; Zwirzitz, B.; Woyda, R.; Lakin, S. M.; Press, M. O.; Cook, K.; Cox, N. A.; Thomas, J. C.; Looft, T. P.; Rothrock, M. J.; Zock, G.; Plumblee Lawrence, J.; Cudnik, D.; Ritz, C.; Aggrey, S. E.
10.1101/2021.04.02.438293 — microbiology — Posted on 2021-06-22
1053 Sensitivity to Immune Checkpoint Blockade and Progression-Free Survival is associated with baseline CD8+ T cell clone size and cytotoxicity
Watson, R. A.; Tong, O.; Cooper, R. A.; Taylor, C. A.; Sharma, P. K.; Verge de los Aires, A.; Mahe, E.; Ruffieux, H.; Nassiri, I.; Middleton, M. R.; Fairfax, B. P.
10.1101/2020.11.15.383786 — immunology — Posted on 2021-06-23
1055 The mouse brain after foot-shock in 4D: temporal dynamics at a single cell resolution
Bonapersona, V.; Schuler, H.; Damsteeg, R. D.; Adolfs, Y.; Pasterkamp, R. J.; van den Heuvel, M. P.; Joels, M.; Sarabdjitsingh, R. A.
10.1101/2021.05.03.442441 — neuroscience — Posted on 2021-06-22
1057 Inhibitory interneurons show early dysfunction in a SOD1 mouse model of ALS
Cavarsan, C. F.; Steele, P. R.; McCane, L. M.; LaPre, K. J.; Puritz, A. C.; Katenka, N.; Quinlan, K. A.
10.1101/2020.10.21.348359 — neuroscience — Posted on 2021-06-22
1058 Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia
Chun, B. J.; Aryal, S.; Sun, B.; Bruno, J.; Richards, C.; Bachstetter, A. D.; Kekenes-Huskey, P. M.
10.1101/2021.06.19.448892 — physiology — Posted on 2021-06-22
1059 A De Novo regulation design shows an effectiveness in altering plant secondary metabolism
Li, M.; He, X.; La Hovary, C.; Zhu, Y.; Dong, Y.; Liu, S.; Xing, H.; Liu, Y.; Jie, Y.; Ma, D.; Yuzuak, S.; Xie, D.-Y.
10.1101/2020.12.20.423678 — bioengineering — Posted on 2021-06-22
1061 A Hypoxia Sensitive to Hypoxia Resistant Transformation in Long-Lived Germline Mutants
Van Gilst, M. R.; Hemphill, C.; Pylarinou-Sinclair, E.; Itani, O.; Scott, B.; Crowder, M.
10.1101/2021.06.22.449397 — genetics — Posted on 2021-06-22
1062 Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV 1/SIVcpz lentiviral lineage
Zhao, Z.; Fagerlund, R.; Sauter, D.; Tossavainen, H.; Permi, P.; Kirchhoff, F.; Saksela, K.
10.1101/2021.06.22.449400 — microbiology — Posted on 2021-06-22
1063 Structurally conserved domains between flavivirus and alphavirus fusion glycoproteins contribute to replication in mammals and infectious virion production.
Rangel, M. V.; Catanzaro, N.; Thannickal, S. A.; Crotty, K. A.; Noval, M. G.; Johnson, K. E. E.; Ghedin, E.; Lazear, H. M.; Stapleford, K. A.
10.1101/2021.06.22.449399 — microbiology — Posted on 2021-06-22
1066 DNA Mutations via Chern-Simons Current
Bajardi, F.; Altucci, L.; Benedetti, R.; Capozziello, S.; Del Sorbo, M. R.; Franci, G.; Altucci, C.
10.1101/2021.06.22.449396 — biophysics — Posted on 2021-06-22
1068 Assembled Cell-Decorated Collagen (AC-DC) bioprinted implants mimic musculoskeletal tissue properties and promote functional recovery
Christensen, K. W.; Turner, J.; Coughenour, K.; Maghdouri-White, Y.; Bulysheva, A. A.; Sheean, A. J.; Christ, G. J.; Francis, M. P.
10.1101/2021.06.22.449431 — bioengineering — Posted on 2021-06-22
1069 Witnessing the Structural Evolution of an RNA Enzyme
Portillo, X.; Huang, Y.-T.; Breaker, R. R.; Horning, D. P.; Joyce, G. F.
10.1101/2021.06.22.449496 — biochemistry — Posted on 2021-06-22
1071 Transcription Factor Activation Profiles (TFAP) identify compounds promoting differentiation of Acute Myeloid Leukemia cell lines
Riccio, F.; Micarelli, E.; Secci, R.; Giuliani, G.; Vumbaca, S.; Massacci, G.; Castagnoli, L.; Fuoco, C.; Cesareni, G.
10.1101/2021.06.22.449489 — cell biology — Posted on 2021-06-22
1072 Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors
Przanowska, R. K.; Weidmann, C. A.; Saha, S.; Cichewicz, M. A.; Jensen, K. N.; Przanowski, P.; Irving, P. S.; Guertin, M. J.; Weeks, K. M.; Dutta, A.
10.1101/2021.06.22.449443 — molecular biology — Posted on 2021-06-22
1073 Regulatory approved monoclonal antibodies contain framework mutations predicted from human antibody repertoires
Petersen, B. M.; Ulmer, S. A.; Rhodes, E. R.; Gutierrez Gonzalez, M. F.; Dekosky, B. J.; Sprenger, K. G.; Whitehead, T. A.
10.1101/2021.06.22.449488 — immunology — Posted on 2021-06-22
1075 Prevalence of white matter pathways coming into a single diffusion MRI voxel orientation: the bottleneck issue in tractography
Schilling, K.; Tax, C. M. W.; Rheault, F. M. W.; Landman, B. A.; Anderson, A. W.; Descoteaux, M.; Petit, L.
10.1101/2021.06.22.449454 — neuroscience — Posted on 2021-06-22
1076 Norepinephrine Potentiates and Serotonin Depresses Visual Cortical Responses by Transforming Eligibility Traces
Hong, S. Z.; Mesik, L.; Grossman, C. D.; Cohen, J. Y.; Lee, B.; Lee, H.-K.; Hell, J. W.; kirkwood, a.
10.1101/2021.06.22.449441 — neuroscience — Posted on 2021-06-22
1077 Evidence for widespread alterations in cortical microstructure after 32 hours of sleep deprivation
Voldsbekk, I.; Bjornerud, A.; Groote, I. R.; Zak, N.; Roelfs, D.; Maximov, I. I.; Geier, O.; Due-Tonnessen, P.; Boen, E.; Kuiper, Y.; Lokken, L.-L.; Stromstad, M.; Blakstvedt, T. Y.; Bjorvatn, B.; Malt, U. F.; Westlye, L. T.; Elvsashagen, T.; Grydeland, H.
10.1101/2021.06.22.449439 — neuroscience — Posted on 2021-06-22
1079 A-type lamins are critical for the recruitment of RPA and RAD51 to stalled replication forks to maintain fork stability
Graziano, S.; Coll-Bonfill, N.; Teodoro-Castro, B.; Kuppa, S.; Jackson, J.; Shashkova, E.; Mahajan, U.; Vindigni, A.; Antony, E.; Gonzalo, S.
10.1101/2021.06.22.449466 — cancer biology — Posted on 2021-06-22
1081 Engineering 3D Vascularized Adipose Tissue Construct using a Decellularized Lung Matrix
DeBari, M. K.; Ng, W. H.; Griffin, M. D.; Kokai, L. E.; Marra, K. G.; Rubin, J. P.; Ren, X.; Abbott, R. D.
10.1101/2021.06.22.449445 — bioengineering — Posted on 2021-06-22
1082 Multiple modes of regulation control dynamic transcription patterns during the mitosis-G1 transition
Wojenski, L. A.; Wainman, L. M.; Villafano, G. J.; Kuhlberg, C.; Nanda, P.; Core, L.
10.1101/2021.06.22.449286 — genomics — Posted on 2021-06-22
1084 Linker histone dH1K27 dimethylation marks Drosophila heterochromatin independently of H3K9 methylation
Bernues, J.; Izquierdo-Boulstridge, A.; Reina Garcia, O.; Castejon, L.; Fernandez-Castaner, E.; Leal, N.; Guerrero-Pepinosa, N.; Bonet-Costa, C.; Vujatovic, O.; Azorin, F.
10.1101/2021.06.22.449135 — molecular biology — Posted on 2021-06-22
1085 Probing interplays between human XBP1u translational arrest peptide and 80S ribosome
Di Palma, F.; Decherchi, S.; Pardo-Avila, F.; Succi, S.; Levitt, M.; von Heijne, G.; Cavalli, A.
10.1101/2021.06.22.449432 — molecular biology — Posted on 2021-06-22
1087 Gut Microbiota predicts Healthy Late-life Aging in Male Mice
Ke, S.; Mitchell, S. J.; MacArthur, M. R.; Kane, A. E.; Sinclair, D. A.; Venable, E. M.; Chadaideh, K. S.; Carmody, R. N.; Grodstein, F.; Mitchell, J. R.; Liu, Y.-Y.
10.1101/2021.06.22.449472 — microbiology — Posted on 2021-06-22
1090 Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.
Sen, A.; Prager, B. C.; Park, D.; Zhu, Z.; Gimple, R. C.; Bernatchez, J. A.; Beck, S.; Clark, A. E.; Siqueira-Neto, J. L.; Rich, J. N.; McVicker, G. P.
10.1101/2021.06.22.449493 — cancer biology — Posted on 2021-06-22
1091 PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes
Gass, M.; Borkowsky, S.; Lotz, M.-L.; Schroeter, R.; Nedvetsky, P.; Luschnig, S.; Rohlmann, A.; Missler, M.; Krahn, M. P.
10.1101/2021.06.22.449474 — cell biology — Posted on 2021-06-22
1096 Structure of the human FERRY Rab5 effector complex
Quentin, D.; Schuhmacher, J.; Klink, B. U.; Lauer, J.; Shaikh, T.; Huis in 't Veld, P. J.; Welp, L. M.; Urlaub, H.; Zerial, M.; Raunser, S.
10.1101/2021.06.21.449265 — biochemistry — Posted on 2021-06-22
1099 High CXCL6 drives matrix expression and correlate with markers of poor outcome in IPF
Bahudhanapati, H.; Tan, J.; Apel, R.-M.; Seeliger, B.; Li, X.; Chen, T.-Y.; Sullivan, D.; Sembrat, J.; Rojas, M.; Valenzi, E.; Lafyatis, R. A.; Jawale, C.; Biswas, P.; Tedrow, J.; Adams, T. S.; Kaminski, N.; Wuyts, W. A.; McDyer, J. F.; Alder, J. K.; Zhang, Y.; Nouraie, M.; Prasse, A.; Kass, D. J.
10.1101/2021.06.22.449424 — cell biology — Posted on 2021-06-22
1100 Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system
Zhang, J. Z.; Yeh, H.-W.; Walls, A. C.; Wicky, B. I.; Sprouse, K.; VanBlargan, L. A.; Treger, R.; Quijano-Rubio, A.; Pham, M. N.; Kraft, J. C.; Haydon, I. C.; Yang, W.; DeWitt, M.; Chow, C.; Carter, L.; Wener, M. H.; Stewart, L.; Veesler, D.; Diamond, M.; Baker, D.
10.1101/2021.06.22.449355 — molecular biology — Posted on 2021-06-22
1101 Cytoplasmic tail truncation of SARS-CoV-2 Spike protein enhances titer of pseudotyped vectors but masks the effect of the D614G mutation
Chen, H.-Y.; Huang, C.; Tian, L.; Huang, X.; Zhang, C.; Llewellyn, G. N.; Rogers, G. L.; Andresen, K.; O'Gorman, M. R. G.; Chen, Y.-W.; Cannon, P. M.
10.1101/2021.06.21.449352 — microbiology — Posted on 2021-06-22
1105 SRF-CLICAL: an approach for patient risk stratification using random forest models
Simao Neto, F. A.; Hieta, R.; Pulman, J. A.; Madonna, G.; Ascierto, P.; Lewensohn, R.; Masucci, G.
10.1101/2021.06.22.448514 — bioinformatics — Posted on 2021-06-22
1107 Genome Sequencing Identifies Previously Unrecognized Klebsiella pneumoniae Outbreaks in Neonatal Intensive Care Units in the Philippines
Carlos, C. C.; Masim, M. A. L.; Lagrada, M. L.; Gayeta, J. M.; Macaranas, P. K. V.; Sia, S. B.; Facun, M. A. M.; Palarca, J. F. C.; Olorosa, A. M.; Cueno, G. A. C.; Abrudan, M.; Abudahab, K.; Argimon, S.; Kekre, M.; Underwood, A.; Stelling, J.; Aanensen, D. M.; The NIHR Global Health Research Unit (GHRU) on Genomic Surveillance of Antimicrobial Resistance,
10.1101/2021.06.22.449363 — genomics — Posted on 2021-06-22
1109 Rapid Genomic Characterization and Global Surveillance of Klebsiella Using Pathogenwatch
Argimon, S.; David, S.; Underwood, A.; Abrudan, M.; Wheeler, N. E.; Kekre, M.; Abudahab, K.; Yeats, C. A.; Goater, R.; Taylor, B.; Harste, H.; Muddyman, D.; Feil, E. J.; Brisse, S.; Holt, K.; Donado-Godoy, P.; Ravikumar, K. L.; Okeke, I. N.; Carlos, C. C.; Aanensen, D. M.
10.1101/2021.06.22.448967 — genomics — Posted on 2021-06-22
1112 RNA at the surface of phase-separated condensates impacts their size and number
Cochard, A.; Garcia-Jove Navarro, M.; Kashida, S.; Kress, M.; Weil, D.; Gueroui, Z.
10.1101/2021.06.22.449254 — cell biology — Posted on 2021-06-22
1114 Dynamic Phosphorylation of RGS Provides Spatial Regulation of G-alpha And Promotes Completion of Cytokinesis
Simke, W. C.; Hart, A. J.; Johnson, C. P.; Mayhue, S.; Craig, P. L.; Sojka, S.; Kelley, J. B.
10.1101/2021.06.22.449324 — cell biology — Posted on 2021-06-22
1115 Protective role of the Atg8 1 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease
Mellor, K. M.; Varma, U.; Koutsifeli, P.; Curl, C. L.; Janssens, J. V.; Daniels, L. J.; Bernasochi, G. B.; Raaijmakers, A. J. A.; Benson, V. L.; Chan, E. J.; Annandale, M.; Li, X.; Nursalim, Y.; Ip, W. T. K.; Taylor, D. J.; Raedschelders, K.; Stotland, A.; Robinson, A. E.; Mills, R. J.; Lamberts, R. R.; Powell, K. L.; O'Brien, T. J.; Katare, R.; Chandramouli, C.; Ritchie, R. H.; Lim, S. Y.; Parton, R. G.; Hu, X.; Bell, J. R.; Porrello, E. R.; Hudson, J. E.; Xiao, R.-P.; Van Eyk, J. E.; Gottlieb, R. A.; Delbridge, L. M. D.
10.1101/2021.06.21.449174 — molecular biology — Posted on 2021-06-22
1117 Hierarchical control of microbial community assembly
Pontrelli, S.; Szabo, R.; Pollak, S.; Schwartzman, J. A.; Ledezma-Tejeida, D.; Cordero, O. X.; Sauer, U.
10.1101/2021.06.22.449372 — microbiology — Posted on 2021-06-22
1118 The effects of long duration spaceflight on sensorimotor control and cognition
Tays, G.; Hupfeld, K.; McGregor, H.; Salazar, A.; DeDios, Y.; Beltran, N.; Reuter-Lorenz, P.; Kofman, I.; Wood, S.; Bloomberg, J.; Mulavara, A.; Seidler, R.
10.1101/2021.06.22.449414 — neuroscience — Posted on 2021-06-22
1119 The Digital Brain Bank: an open access platform for post-mortem datasets
Tendler, B. C.; Hanayik, T.; Ansorge, O.; Bangerter-Christensen, S.; Berns, G. S.; Bertelsen, M. F.; Bryant, K. L.; Foxley, S.; Howard, A. F. D.; Huszar, I.; Khrapitchev, A. A.; Leonte, A.; Manger, P. R.; Menke, R. A. L.; Mollink, J.; Mortimer, D.; Pallebage-Gamarallage, M.; Roumazeilles, L.; Sallet, J.; Scott, C.; Smart, A.; Turner, M. R.; Wang, C.; Jbabdi, S.; Mars, R. B.; Miller, K. L.
10.1101/2021.06.21.449154 — neuroscience — Posted on 2021-06-22
1121 Hyperactive WNT/CTNNB1 signaling induces a competing cell proliferation and epidermal differentiation response in the mouse mammary epithelium
Mourao, L.; Zeeman, A. L.; Wiese, K. E.; Bongaarts, A.; Oudejans, L. L.; Mora Martinez, I.; van de Grift, Y. B. C.; Jonkers, J.; van Amerongen, R.
10.1101/2021.06.22.449461 — cancer biology — Posted on 2021-06-22
1122 MONTE enables serial immunopeptidome, ubiquitylome, proteome, phosphoproteome, acetylome analyses of sample-limited tissues
Abelin, J. G.; Bergstrom, E. J.; Taylor, H. B.; Rivera, K. D.; Klaeger, S.; Olive, M. E.; Clauser, K. R.; White, C. J.; Maynard, M.; Kane, M. H.; Pearce, C.; Rachimi, S.; Gillette, M. A.; Satpathy, S.; Udeshi, N. D.; Carr, S. A.
10.1101/2021.06.22.449417 — cancer biology — Posted on 2021-06-22
1123 Crisscross multilayering of cell sheets
Sarkar, T.; Yashunsky, V.; Brezin, L.; Mercader, C. B.; Aryaksama, T.; Lacroix, M.; Risler, T.; Joanny, J.-F.; Silberzan, P.
10.1101/2021.06.22.449403 — biophysics — Posted on 2021-06-22
1126 Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade
Yagi-Utsumi, M.; Aoki, K.; Watanabe, H.; Song, C.; Nishimura, S.; Satoh, T.; Yanaka, S.; Ganser, C.; Tanaka, S.; Schnapka, V.; Goh, E. W.; Furutani, Y.; Murata, K.; Uchihashi, T.; Arakawa, K.; Kato, K.
10.1101/2021.06.22.449423 — biochemistry — Posted on 2021-06-22
1127 A Thioredoxin reductive mechanism balances the oxidative protein import pathway in the intermembrane space of mitochondria
Cardenas-Rodriguez, M.; Manganas, P.; Kallergi, E.; Edwards, R.; Chatzi, A.; Lacko, E.; Tokatlidis, K.
10.1101/2021.06.22.449413 — biochemistry — Posted on 2021-06-22
1129 Complexity of genomic epidemiology of carbapenem-resistant Klebsiella pneumoniae isolates in Colombia urges the reinforcement of whole genome sequencing based surveillance programs
Saavedra, S. Y.; Bernal, J. F.; Escudero, E. M.; Arevalo, S. A.; Prada, D. A.; Valencia, M. F.; Moreno, J.; Hidalgo, A. M.; Abrudan, M.; Argimon, S.; Kekre, M.; Underwood, A.; Aanensen, D. M.; Duarte, C.; Donado-Godoy, P.
10.1101/2021.06.21.449250 — genomics — Posted on 2021-06-22
1130 Dystonia-specific mutations in THAP1 alter transcription of genes associated with neurodevelopment and myelin
Domingo, A.; Yadav, R.; Shah, S.; Hendriks, W. T.; Erdin, S.; Gao, D.; O'Keefe, K.; Currall, B.; Gusella, J. F.; Sharma, N.; Ozelius, L. J.; Ehrlich, M. E.; Talkowski, M. E.; Bragg, D. C.
10.1101/2021.06.22.449452 — genetics — Posted on 2021-06-22
1135 Quantifying invasibility
Pande, J.; Tsubery, Y.; Shnerb, N.
10.1101/2021.06.22.449376 — ecology — Posted on 2021-06-22
1140 Epigenetic therapy suppresses endocrine-resistant breast tumour growth by re-wiring ER-mediated 3D chromatin interactions
Achinger-Kawecka, J.; Stirzaker, C.; Chia, K.-M.; Portman, N.; Campbell, E.; Du, Q.; Laven-Law, G.; Nair, S.; Yong, A.; Wilkinson, A.; Clifton, S.; Milioli, H. H.; Schmitt, A.; Wong, E.; Hickey, T.; Lim, E.; Clark, S.
10.1101/2021.06.21.449340 — molecular biology — Posted on 2021-06-22
1143 Targeting activated macrophages intracellular milieu to augment anti-inflammatory drug potency
Gouveia, V. M.; Rizzello, L.; Vidal, B.; Nunes, C.; Poma, A.; Lopez-Vasquez, C.; Scarpa, E.; Brander, S.; Oliveira, A.; Fonseca, J. E.; Reis, S.; Battaglia, G.
10.1101/2021.06.22.449368 — immunology — Posted on 2021-06-22
1144 Human DC3 Antigen Presenting Dendritic Cells from Induced Pluripotent Stem Cells
Satoh, T.; Szymanski de Toledo, M. A.; Boehnke, J.; Olschok, K.; Flosdorf, N.; Goetz, K.; Kuestermann, C.; Sontag, S.; Sere, K.; Koschmieder, S.; Bruemmendorf, T. H.; Chatain, N.; Tagawa, Y.-i.; Zenke, M.
10.1101/2021.06.22.449451 — immunology — Posted on 2021-06-22
1147 Electrophysiological correlates of perceptual prediction error are attenuated in dyslexia
Beach, S. D.; Lim, S.-J.; Cardenas-Iniguez, C.; Eddy, M. D.; Gabrieli, J. D. E.; Perrachione, T. K.
10.1101/2021.06.22.449408 — neuroscience — Posted on 2021-06-22
1148 Gestational methylazoxymethanol acetate administration alters α5GABAA and NMDA receptor density: An integrated neuroimaging, behavioral and pharmacological study
Kiemes, A.; Gomes, F. V.; Cash, D.; Uliana, D. L.; Simmons, C.; Singh, N.; Vernon, A. C.; Turkheimer, F. E.; Davies, C.; Stone, J. M.; Grace, A. A.; Modinos, G.
10.1101/2021.06.21.449343 — neuroscience — Posted on 2021-06-22
1152 Task complexity temporally extends the causal requirement for visual cortex in perception
Oude Lohuis, M. N.; Pie, J. L.; Marchesi, P.; Montijn, J. S.; de Kock, C. P. J.; Pennartz, C. M. A.; Olcese, U.
10.1101/2021.06.22.449366 — neuroscience — Posted on 2021-06-22
1161 USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma
Ruiz, E. J.; Pinto-Fernandez, A.; Turnbull, A. P.; Lan, L.; Charlton, T. M.; Scott, H. C.; Damianou, A.; Vere, G.; Riising, E. M.; Da Costa, C.; Krajewski, W. W.; Guerin, D.; Kearns, J.; Ioannidis, S.; Katz, M.; McKinnon, C.; O'Connell, J. C.; Moncaut, N.; Rosewell, I.; Nye, E.; Jones, N.; Heride, C.; Gersch, M.; Wu, M.; Dinsmore, C. J.; Hammonds, T. R.; Kim, S.; Komander, D.; Urbe, S.; Clague, M. J.; Kessler, B. M.; Behrens, A.
10.1101/2020.11.17.377705 — cancer biology — Posted on 2021-06-22
1163 Immunosuppressive traits of the hybrid epithelial/mesenchymal phenotype
Sahoo, S.; Nayak, S. P.; Hari, K.; Mandal, S.; Kishore, A.; Levine, H.; Jolly, M. K.
10.1101/2021.06.21.449285 — cancer biology — Posted on 2021-06-22
1164 Inhibiting adenine synthesis attenuates glioblastoma cell stemness and temozolomide resistance
Singh, S. X.; Yang, R.; Roso, K.; Hansen, L. J.; Du, C.; Chen, L. H.; Greer, P. K.; Pirozzi, C. J.; He, Y.
10.1101/2021.06.21.449341 — cancer biology — Posted on 2021-06-22
1175 Deep Learning Decodes Multi-layered Roles of Polycomb Repressor Complex 2 During Mouse CNS Development
Mora, A.; Rakar, J.; Cobeta, I. M.; Yaghmaeian Salmani, B.; Starkenberg, A.; Thor, S.; Boden, M.
10.1101/2021.06.22.449386 — bioinformatics — Posted on 2021-06-22
1177 Efficient Generative Modelling of Protein Structure Fragments using a Deep Markov Model
Thygesen, C. B.; Al-Sibahi, A. S.; Moreta, L. S.; Skjodt Steenmans, C.; Bundgard Sorensen, A.; Hamelryck, T. W.
10.1101/2021.06.22.449406 — bioinformatics — Posted on 2021-06-22
1181 Evaluating the cost of pharmaceutical purification for a long-duration space exploration medical foundry
McNulty, M. J.; Berliner, A. J.; Negulescu, P. G.; McKee, L.; Hart, O.; Yates, K.; Arkin, A. P.; Nandi, S.; McDonald, K. A.
10.1101/2021.06.21.449300 — bioengineering — Posted on 2021-06-22
1184 Mechanisms of DNA repair have evolved to minimise the probability of nonsense mutations.
Powell, G.; Long, H. S.; Versluys, T. M. M.; Mallon, A.-M.; Lindgren, C.; Simon, M.
10.1101/2021.06.22.449367 — genomics — Posted on 2021-06-22
1185 Genomics analysis of Drosophila sechellia response to Morinda citrifolia fruit diet
Coolon, J. D.; Drum, Z.; Lanno, S.; Gregory, S.; Shimshak, S.; Barr, W.; Gatesman, A.; Schadt, M.; Sanford, J.; Arkin, A. R.; Assignon, B.; Colorado, S.; Dalgarno, C.; Devanny, T.; Ghandour, T.; Griffin, R.; Hogan, M.; Horowitz, E.; McGhie, E.; Multer, J.; O'Halloran, H.; Ofori-Darko, K.; Pokushalov, D.; Richards, N.; Sagarin, K.; Taylor, N.; Thielking, A.; Towle, P.
10.1101/2021.06.21.449329 — genomics — Posted on 2021-06-22
1186 Genomic sequencing of Lowe syndrome trios reveal a mechanism for the heterogeneity of neurodevelopmental phenotypes
Ahmed P, H.; Singh, P.; Thakur, R.; Kumari, A.; Krishnan, H.; Philip, R. G.; Vasudevan, A.; PADINJAT, R.
10.1101/2021.06.22.449382 — genomics — Posted on 2021-06-22
1189 Essential role for Ggct in erythrocyte antioxidant defense
He, Z.; Sun, X.; Wang, S.; Bai, D.; Zhao, X.; Han, Y.; Hao, P.; Liu, X.-S.
10.1101/2021.06.21.449332 — genetics — Posted on 2021-06-22
1192 A conserved trans regulatory loop involving an odorant binding protein controls male mating behavior in flies
Delclos, P. J.; Adhikari, K.; Hassan, O.; Oderhowho, A. A.; Sriskantharajah, V.; Trinh, T.; Meisel, R. P.
10.1101/2021.06.22.447776 — evolutionary biology — Posted on 2021-06-22
1197 Climatic niche conservatism shapes the ecological assembly of Hawaiian arthropod communities
Lim, J. Y.; Patino, J.; Noriyuki, S.; Simmari, L. C.; Gillespie, R. G.; Krehenwinkel, H.
10.1101/2021.06.22.449388 — ecology — Posted on 2021-06-22
1201 Inhibition of N-myristoyltransferase Promotes Naive Pluripotency in Mouse and Human Pluripotent Stem Cells
Yoshida, J.; Watanabe, H.; Yamauchi, K.; Nishikubo, T.; Isotani, A.; Ohtsuka, S.; Niwa, H.; Akutsu, H.; Umezawa, A.; Suemori, H.; Takashima, Y.; Kondoh, G.; Takeda, J.; Horie, K.
10.1101/2021.06.22.449326 — developmental biology — Posted on 2021-06-22
1205 Mucosal immunization with DTaP confers protection against Bordetella pertussis infection and cough in Sprague-Dawley rats
Hall, J. M.; Bitzer, G. J.; DeJong, M. A.; Kang, J.; Wong, T. Y.; Wolf, M. A.; Bevere, J. R.; Barbier, M.; Damron, F. H.
10.1101/2021.06.21.449353 — microbiology — Posted on 2021-06-22
1208 Inflammation induces pro-NETotic neutrophils via TNFR2 signaling
Neuenfeldt, F.; Schumacher, J. C.; Grieshaber-Bouyer, R.; Habicht, J.; Schröder-Braunstein, J.; Gauss, A.; Niesler, B.; Heineken, N.; Dalpke, A.; Gaida, M. M.; Giese, T.; Meuer, S.; Samstag, Y.; Wabnitz, G.
10.1101/2021.06.21.448937 — immunology — Posted on 2021-06-22
1210 Fatty acid dysregulation in the anterior cingulate cortex of depressed suicides with a history of child abuse
Perlman, K.; Chouinard-Watkins, R.; Tanti, A.; Cisbani, G.; Orri, M.; Turecki, G.; Bazinet, R. P.; Mechawar, N.
10.1101/2021.06.21.449337 — neuroscience — Posted on 2021-06-22
1211 Fate transitions in Drosophila neural lineages: a single cell road map to mature neurons.
Marques, G. S.; Teles-Reis, J.; Konstantinides, N.; Brito, P. H.; Homem, C. C. F.
10.1101/2021.06.22.449317 — neuroscience — Posted on 2021-06-22
1213 Comparison of undirected frequency-domain connectivity measures for cerebro-peripheral analysis
Gross, J.; Kluger, D. S.; Abbasi, O.; Chalas, N.; Steingraeber, N.; Daube, C.; Schoffelen, J.-M.
10.1101/2021.06.22.449393 — neuroscience — Posted on 2021-06-22
1216 High-Resolution Genomic Profiling of Carbapenem-Resistant Klebsiella pneumoniae Isolates: A Multicentric Retrospective Indian Study
Nagaraj, G.; Ravikumar, K.; Govindan, V.; Shama, V.; Rose, S.; Sravani, D.; Akshatha, K. P.; M R, S.; Venkatesha, V. T.; Abrudan, M.; Argimon, S.; Kekre, M.; Underwood, A.; Aanensen, D.
10.1101/2021.06.21.449240 — genomics — Posted on 2021-06-22
1217 Tau assemblies enter the cytosol of neurons in a cholesterol sensitive manner
Tuck, B. J.; Katsinelos, T.; Miller, L. V. C.; Cheng, S.; Vaysburd, M. J.; Knox, C.; Tredgett, L.; James, L. C.; McEwan, W. A.
10.1101/2021.06.21.449238 — cell biology — Posted on 2021-06-22
1227 Genetics of tibia bone properties of crossbred commercial laying hens in different housing systems
Johnsson, M.; Wall, H.; Lopes Pinto, F. A.; Fleming, R. H.; McCormack, H. A.; Benavides-Reyes, C.; Dominguez-Gasca, N.; Sanchez-Rodriguez, E.; Dunn, I. C.; Rodriguez-Navarro, A. B.; Kindmark, A.; de Koning, D.-J.
10.1101/2021.06.21.449243 — genetics — Posted on 2021-06-22
1228 Dopamine Signaling in the Dorsomedial Striatum Promotes Compulsive Behavior
Seiler, J. L.; Cosme, C. V.; Sherathiya, V. N.; Bianco, J. M.; Bridgemohan, A. S.; Lerner, T. N.
10.1101/2020.03.30.016238 — neuroscience — Posted on 2021-06-22
1229 Distinct Synaptic Transfer Functions in Same-Type Photoreceptors
Schroeder, C.; Oesterle, J.; Berens, P.; Yoshimatsu, T.; Baden, T.
10.1101/2021.02.24.432674 — neuroscience — Posted on 2021-06-22
1231 Identification of the key role of white matter alteration in the pathogenesis of Huntington's Disease
Perot, J.-B.; Celestine, M.; Palombo, M.; Dhenain, M.; Humbert, S.; Brouillet, E.; Flament, J.
10.1101/2021.06.21.449242 — neuroscience — Posted on 2021-06-22
1233 Constitutive IFNα protein production in bats
Bondet, V.; Le Baut, M.; Le Poder, S.; Lecu, A.; Petit, T.; Wedlarski, R.; Duffy, D.; Le Roux, D.
10.1101/2021.06.21.449208 — zoology — Posted on 2021-06-22
1234 Train-the-Trainer as an Effective Approach to Building Global Networks of Experts in Genomic Surveillance of AMR
Abrudan, M.; Matimba, A.; Nikolic, D.; Hughes, D.; Argimon, S.; Kekre, M.; Underwood, A.; Aanensen, D.; The NIHR Global Health Research Unit (GHRU) on Genomic Surveillance of Antimicrobial Resistance,
10.1101/2021.06.18.448940 — scientific communication and education — Posted on 2021-06-22
1235 Fibronectin meshwork controls epithelial stem cell fate
Estrach, S.; Tosello, L.; Tissot, F. S.; Cailleteau, L.; Cervera, L.; Jensen, K. B.; Feral, C. C.
10.1101/2021.05.26.445735 — physiology — Posted on 2021-06-22
1236 Analysis of the H-Ras mobility pattern in vivo shows cellular heterogeneity inside epidermal tissue
Gora, R. J.; de Jong, B.; van Hage, P.; Rhiemus, M. A.; van Steenis, F.; van Noort, J.; Schmidt, T.; Schaaf, M.
10.1101/2021.06.21.449125 — biophysics — Posted on 2021-06-22
1239 VarGenius-HZD allows accurate detection of rare homozygous or hemizygous deletions in targeted sequencing leveraging breadth of coverage
Musacchia, F.; Karali, M.; Torella, A.; Laurie, S.; Policastro, V.; Pizzo, M.; Beltran, S.; Casari, G.; Nigro, V.; Banfi, S.
10.1101/2021.06.21.449209 — genomics — Posted on 2021-06-22
1241 Ecological memory of prior nutrient exposure in the human gut microbiome
Letourneau, J.; Holmes, Z. C.; Dallow, E. P.; Durand, H. K.; Jiang, S.; Gupta, S. K.; Mincey, A. C.; Muehlbauer, M. J.; Bain, J. R.; David, L. A.
10.1101/2021.06.21.448853 — ecology — Posted on 2021-06-22
1242 Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns
Shahal, T.; Segev, E.; Konstantinovsky, T.; Marcus, Y.; Shefer, G.; Pasmanik-Chor, M.; Buch, A.; Ebenstein, Y.; Zimmet, P.; Stern, N.
10.1101/2021.06.20.449142 — developmental biology — Posted on 2021-06-22
1243 Evolution of lbx spinal cord expression and function
Juarez-Morales, J. L.; Weierud, F.; England, S.; Demby, C.; Santos, N.; Grieb, G.; Mazan, S.; Lewis, K.
10.1101/2020.12.30.424885 — developmental biology — Posted on 2021-06-22
1244 Structural insights into ligand recognition and activation of the melanocortin-4 receptor
Zhang, Y.; Zhang, H.; Chen, L.-N.; Yang, D.; Mao, C.; Shen, Q.; Feng, W.; Shen, D.-D.; Dai, A.; Xie, S.; Zhou, Y.; Qin, J.; Sun, J.; Scharf, D. H.; Hou, T.; Zhou, T.; Wang, M.-W.
10.1101/2021.06.21.449233 — molecular biology — Posted on 2021-06-22
1245 ALS-FUS mutation affects the activities of HuD/ELAVL4 and FMRP leading to axon phenotypes in motoneurons
Garone, M. G.; Birsa, N.; Rosito, M.; Salaris, F.; Mochi, M.; de Turris, V.; Nair, R. R.; Cunningham, T. J.; Fisher, E. M. C.; Morlando, M.; Fratta, P.; Rosa, A.
10.1101/2020.08.26.268631 — neuroscience — Posted on 2021-06-22
1246 A streamlined CRISPR workflow to introduce mutations and generate isogenic iPSCs for modeling amyotrophic lateral sclerosis
Deneault, E.; Chaineau, M.; Castellanos-Montiel, M. J.; Franco Flores, A. K.; Haghi, G.; Chen, C. X.- Q.; Abdian, N.; Nicouleau, M.; Shlaifer, I.; Beitel, L. K.; Durcan, T. M.
10.1101/2021.06.21.449257 — neuroscience — Posted on 2021-06-22
1247 Omics-based label-free metabolic flux inference reveals dysregulation of glucose metabolism in liver associated with obesity
Uematsu, S.; Ohno, S.; Tanaka, K. Y.; Hatano, A.; Kokaji, T.; Ito, Y.; Kubota, H.; Hironaka, K.-i.; Suzuki, Y.; Matsumoto, M.; Nakayama, K. I.; Hirayama, A.; Soga, T.; Kuroda, S.
10.1101/2021.06.21.449220 — systems biology — Posted on 2021-06-22
1251 Phytochrome gene expression studies: PHYE is required for FR-induced expression of PHYA and PHYD suppresses expression of PHYA
Shapulatov, U.; Meisenburg, M.; van hoogdalem, m.; van Hall, A.; Van Ieperen, W.; van Wassenaar, M.; van der Krol, A. R.
10.1101/2021.06.20.449137 — plant biology — Posted on 2021-06-22
1252 The AMIGO1 adhesion protein modulates movement of Kv2.1 voltage sensors
Sepela, R. J.; Stewart, R. G.; Valencia, L.; Thapa, P.; Wang, Z.; Cohen, B. E.; Sack, J. T.
10.1101/2021.06.20.448455 — biophysics — Posted on 2021-06-22
1253 Clones and Clusters of Antimicrobial-Resistant Klebsiella from Southwestern Nigeria
Afolayan, A. O.; Oaikhena, A. O.; Aboderin, A. O.; Olabisi, O. F.; Amupitan, A. A.; Abiri, O. V.; Ogunleye, V. O.; Odih, E. E.; Adeyemo, A. T.; Adeyemo, A. T.; Obadare, T. O.; Abrudan, M.; Argimon, S.; David, S.; Kekre, M.; Underwood, A.; Egwuenu, A.; Ihekweazu, C.; Aanensen, D. M.; Okeke, I. N.
10.1101/2021.06.21.449255 — genomics — Posted on 2021-06-22
1254 Neuronal cultures show bidirectional axonal conduction with antidromic action potentials depolarizing the soma
Mateus, J.; Lopes, C.; Aroso, M.; Costa, A.; Geros, A.; Meneses, J.; Faria, P.; Neto, E.; Lamghari, M.; Sousa, M.; Aguiar, P.
10.1101/2021.03.07.434278 — neuroscience — Posted on 2021-06-22
1256 Modulation of pulsatile GnRH dynamics across the ovarian cycle: the role of glutamatergic transmission in the arcuate kisspeptin network.
Voliotis, M.; Li, X. F.; De Burgh, R.; Lass, G.; Ivanova, D.; McIntyre, C.; O'Byrne, K. T.; Tsaneva-Atanasova, K.
10.1101/2021.03.22.436428 — neuroscience — Posted on 2021-06-22
1258 Protozoa populations are ecosystem engineers that shape prokaryotic community structure and function of the rumen microbial ecosystem
Solomon, R.; Wein, T.; Levy, B.; Eshed, S.; Dror, R.; Reiss, V.; Zehavi, T.; Furman, O.; Mizrahi, I.; Jami, E.
10.1101/2020.05.15.080218 — microbiology — Posted on 2021-06-22
1259 TOR represses stress responses through global regulation of H3K27 trimethylation in plants
Dong, Y.; Uslu, V. V.; Berr, A.; Singh, G.; Papdi, C.; Steffens, V. A.; HEITZ, T.; Ryabova, L.
10.1101/2021.03.28.437410 — plant biology — Posted on 2021-06-22
1263 Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq-guided combination with sapanisertib
Lim, C.; Dismuke, T.; Malawsky, D.; Ramsey, J. D.; Hwang, D.; Godfrey, V. L.; Kabanov, A. V.; Gershon, T. R.; Sokolsky, M.
10.1101/2021.06.09.447757 — cancer biology — Posted on 2021-06-22
1264 CancerMIRNome: an interactive analysis and visualization database for miRNome profiles of human cancer
Li, R.; Qu, H.; Wang, S.; Wang, X.; Cui, Y.; Yu, L.; Chater, J. M.; Zhou, R.; Jia, Q.; Traband, R.; Wang, M.; Yuan, D.; Zhu, J.; Zhong, W.-D.; Jia, Z.
10.1101/2020.10.04.325670 — bioinformatics — Posted on 2021-06-21
1267 CancerMIRNome: an interactive analysis and visualization database for miRNome profiles of human cancer
Li, R.; Qu, H.; Wang, S.; Wang, X.; Cui, Y.; Yu, L.; Chater, J. M.; Zhou, R.; Jia, Q.; Traband, R.; Wang, M.; Yuan, D.; Zhu, J.; Zhong, W.-D.; Jia, Z.
10.1101/2020.10.04.325670 — bioinformatics — Posted on 2021-06-21
1269 Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the Dos dormancy regulon
Sevalkar, R. R.; Glasgow, J. N.; Pettinati, M.; Martin, M. A.; Reddy, V. P.; Basu, S.; Alipour, E.; Kim-Shapiro, D. B.; Estrin, D. A.; Lancaster, J. R.; Steyn, A. J.
10.1101/2021.06.21.449194 — biochemistry — Posted on 2021-06-21
1271 Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs
Shen, Z.; Li, R. Z.; Prohaska, T. A.; Hoeksema, M. A.; Spann, N. J.; Tao, J.; Fonseca, G. J.; Le, T.; Stolze, L.; Sakai, M.; Romanoski, C. E.; Glass, C. K.
10.1101/2020.04.02.021535 — genomics — Posted on 2021-06-21
1272 Introduction of probiotic bacterial consortia promotes plant growth via impacts on the resident rhizosphere microbiome
Hu, J.; Yang, T.; Friman, V. P.; Kowalchuk, G. A.; Hautier, Y.; Li, M.; Wei, Z.; Xu, Y. C.; Shen, Q. R.; Jousset, A.
10.1101/2021.06.21.449210 — ecology — Posted on 2021-06-21
1273 Identification of the stress granule transcriptome via RNA-editing in single cells and in vivo
Leeuwen, W. v.; VanInsberghe, M.; Battich, N.; Salmen, F.; van Oudenaarden, A.; Rabouille, C.
10.1101/2021.06.21.449212 — cell biology — Posted on 2021-06-21
1276 Impacts of Mycoplasma agalactiae restriction-modification systems on pan-epigenome dynamics and genome plasticity
Dordet-Frisoni, E.; Vandecasteele, C.; Contarin, R.; Sagne, E.; Baranowski, E.; Klopp, C.; Nouvel, X.; Citti, C.
10.1101/2021.06.21.448925 — microbiology — Posted on 2021-06-21
1277 Diversity and evolution of pigment types and the phycobilisome rod gene region of marine Synechococcus cyanobacteria
Grebert, T.; Garczarek, L.; Daubin, V.; Humily, F.; Marie, D.; Ratin, M.; Devailly, A.; Farrant, G. K.; Mary, I.; Mella-Flores, D.; Tanguy, G.; Labadie, K.; Wincker, P.; Kehoe, D. M.; Partensky, F.
10.1101/2021.06.21.449213 — microbiology — Posted on 2021-06-21
1278 Role of collagen-like protein BclA3 in the assembly of the exosporium layer of Clostridioides difficile spores.
Pizarro-Guajardo, M.; Ortega-Lizarraga, C.; Inostroza-Mora, A.; Cid-Rojas, F.; Paredes-Sabja, D.
10.1101/2021.06.21.449304 — microbiology — Posted on 2021-06-21
1280 The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients
Kim, C.; Latif, I.; Neupane, D. P.; Lee, G. Y.; Kwon, R. S.; Batool, A.; Ahmed, Q.; Qamar, M. U.; Song, J.
10.1101/2021.06.20.449163 — microbiology — Posted on 2021-06-21
1281 Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune pathways related to tissue injury
Cross, A. R.; de Andrea, C.; Landecho Acha, M.; Cerundolo, L.; Etherington, R.; Denney, L.; Ho, L.-P.; Roberts, I.; Klenerman, P.; Hester, J.; Melero, I.; Sansom, S.; Issa, F.
10.1101/2021.06.21.449178 — immunology — Posted on 2021-06-21
1283 Predictive feedback, early sensory representations and fast responses to predicted stimuli depend on NMDA receptors
Mohanta, S.; Afrasiabi, M.; Casey, C.; Tanabe, S.; Redinbaugh, M. J.; Kambi, N. A.; Phillips, J. M.; Polyakov, D.; Filbey, W.; Austerweil, J. L.; Sanders, R. D.; Saalmann, Y. B.
10.1101/2020.01.06.896589 — neuroscience — Posted on 2021-06-21
1285 Identifying developing interneurons as a potential target for multiple genetic autism risk factors in human and rodent forebrain.
Yang, Y.; Booker, S. A.; Clegg, J. M.; Quintana-Urzainqui, I.; Sumera, A.; Kozic, Z. R.; Dando, O. R.; Martin Lorenzo, S.; Herault, Y.; Kind, P. C.; Price, D. J.; Pratt, T.
10.1101/2021.06.03.446920 — neuroscience — Posted on 2021-06-21
1287 N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease.
Shewell, L. K.; Day, C. J.; Kutasovic, J. R.; Abrahams, J. L.; Wang, J.; Poole, J.; Niland, C.; Ferguson, K.; Saunus, J. M.; Lakhani, S. R.; Itzstein, M. v.; Paton, J. C.; Paton, A. W.; Jennings, M. P.
10.1101/2021.06.21.449179 — cancer biology — Posted on 2021-06-21
1289 Wuschel2 enables highly efficient CRISPR/Cas-targeted genome editing during rapid de novo shoot regeneration in sorghum
Che, P.; Wu, E.; Simon, M. K.; Anand, A.; Lowe, K.; Gao, H.; Sigmund, A. L.; Yang, M.; Albertsen, M. C.; Gordon-Kamm, W.; Jones, T. J.
10.1101/2021.06.21.449302 — developmental biology — Posted on 2021-06-21
1292 The NDP52/CALCOCO2 selective autophagy receptor controls processing body disassembly
Robinson, C.-A.; Singh, G. K.; Castle, E. L.; Boudreau, B. Q.; Corcoran, J.
10.1101/2021.02.07.430164 — cell biology — Posted on 2021-06-21
1293 A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium
van der Linden, F. H.; Mahlandt, E. K.; Arts, J. J. G.; Beumer, J.; Puschhof, J.; de Man, S. M. A.; Chertkova, A. O.; Ponsioen, B.; Clevers, H.; van Buul, J. D.; Postma, M.; Gadella, T. W. J.; Goedhart, J.
10.1101/2021.06.21.449214 — cell biology — Posted on 2021-06-21
1295 Mapping the invisible chromatin transactions of prophase chromosome remodelling
SAMEJIMA, I.; Spanos, C.; Samejima, K.; Rappsilber, J.; Kustatscher, G.; Earnshaw, W. C.
10.1101/2021.06.21.449273 — cell biology — Posted on 2021-06-21
1296 Detecting Flavobacterial Fish Pathogens in the Environment Using High-Throughput Community Analysis
Testerman, T.; Beka, L.; McClure, E. A.; Reichley, S. R.; King, S.; Welch, T. J.; Graf, J.
10.1101/2021.06.21.447745 — molecular biology — Posted on 2021-06-21
1298 The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a developmentally distinct extracellular state
Atwal, S.; Wongsantichon, J.; Giengkam, S.; Saharat, K.; Jaiyen, Y.; Chuenklin, S.; Chung, T.; Huh, H.; Lee, S.; Sobota, R.; Salje, J.
10.1101/2020.03.03.975011 — microbiology — Posted on 2021-06-21
1299 L-form switching confers antibiotic, phage and stress tolerance in pathogenic Escherichia coli
Petrovic Fabijan, A.; Kamruzzaman, M.; Martinez Martin, D.; Venturini, C.; Mickiewicz, K.; Flores Rodriguez, N.; Errington, J.; Iredell, J. R.
10.1101/2021.06.21.449206 — microbiology — Posted on 2021-06-21
1300 Artemisinin-based hybrids produce intracellular proteasome inhibitors that overcome resistance in Plasmodium falciparum
Zhan, W.; Liu, Y. J.; Yang, C.; Zhang, H.; Harris, J. C.; Wang, R.; Zhu, S.; Sherman, J.; Sukenick, G.; Rodriguez, A.; Deng, H.; Nathan, C. F.; Kirkman, L. A.; Lin, G.
10.1101/2021.06.21.449268 — microbiology — Posted on 2021-06-21
1303 Antibiotics drive expansion of rare pathogens in a chronic infection microbiome model
Varga, J. J.; Zhao, C.; Davis, J. D.; Hao, Y.; Farrell, J. M.; Gurney, J. R.; Voit, E.; Brown, S. P.
10.1101/2021.06.21.449018 — microbiology — Posted on 2021-06-21
1304 Protozoa populations are ecosystem engineers that shape prokaryotic community structure and function of the rumen microbial ecosystem
Solomon, R.; Wein, T.; Levy, B.; Eshed, S.; Dror, R.; Reiss, V.; Zehavi, T.; Furman, O.; Mizrahi, I.; Jami, E.
10.1101/2020.05.15.080218 — microbiology — Posted on 2021-06-21
1306 Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2
Kageyama, T.; Tanaka, S.; Etori, K.; Hattori, K.; Miyachi, K.; Kasuya, T.; Iwamoto, T.; Ikeda, K.; Igari, H.; Yokote, K.; Nakajima, H.
10.1101/2021.06.21.449182 — immunology — Posted on 2021-06-21
1307 Reassessing associations between white matter and behaviour with multimodal microstructural imaging
Lazari, A.; Salvan, P.; Cottaar, M.; Papp, D.; van der Werf, O. J.; Johnstone, A.; Sanders, Z.-B.; Sampaio-Baptista, C.; Eichert, N.; Miyamoto, K.; Winkler, A.; Callaghan, M. F.; Nichols, T. E.; Stagg, C. J.; Rushworth, M.; Verhagen, L.; Johansen-Berg, H.
10.1101/2020.12.15.422826 — neuroscience — Posted on 2021-06-21
1308 The Impact of Neuron Morphology on Cortical Network Architecture
Udvary, D.; Harth, P.; Macke, J. H.; Hege, H.-C.; de Kock, C. P. J.; Sakmann, B.; Oberlaender, M.
10.1101/2020.11.13.381087 — neuroscience — Posted on 2021-06-21
1309 The medial orbitofrontal cortex - basolateral amygdala circuit regulates the influence of reward cues on adaptive behavior and choice
Lichtenberg, N. T.; Sepe-Forrest, L.; Pennington, Z. T.; Lamparelli, A. C.; Greenfield, V. Y.; Wassum, K. M.
10.1101/2021.04.27.441665 — neuroscience — Posted on 2021-06-21
1310 Genetically-Modified Macrophages Accelerate Myelin Repair
Tepavcevic, V.; Dufayet-Chaffaud, G.; Aigrot, M.-S.; Moyon, S.; Gillet-Legrand, B.; Tada, S.; Izagirre, L.; Cartier, N.; Lubetzki, C.
10.1101/2020.10.28.358705 — neuroscience — Posted on 2021-06-21
1312 Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly
Trotter, J. H.; Dargaei, Z.; Sclip, A.; Essayan-Perez, S.; Liakath-Ali, K.; Raju, K.; Nabet, A.; Liu, X.; Wohr, M.; Sudhof, T.
10.1101/2020.08.21.262097 — neuroscience — Posted on 2021-06-21
1317 Define protein variant functions with high-complexity mutagenesis libraries and enhanced mutation detection software ASMv1.0
Yang, X.; Hong, A. L.; Sharpe, T.; Giacomelli, A. O.; Lintner, R. E.; Alan, D.; Green, T.; Hayes, T. K.; Piccioni, F.; Fritchman, B.; Kawabe, H.; Sawyer, E.; Sprenkle, L.; Lee, B. P.; Persky, N. S.; Brown, A.; Greulich, H.; Aguirre, A. J.; Meyerson, M.; Hahn, W. C.; Johannessen, C. M.; Root, D. E.
10.1101/2021.06.16.448102 — systems biology — Posted on 2021-06-21
1318 Targeting riboswitches with synthetic small RNAs for metabolic engineering
Lins, M. R. d. C. R.; Amorim, L. A. d. S.; Correa, G. G.; Picao, B. W.; Mack, M.; Cerri, M. O.; Pedrolli, D. B.
10.1101/2021.06.21.449321 — synthetic biology — Posted on 2021-06-21
1320 S-nitrosoglutathione reductase deficiency causes aberrant placental S-nitrosylation and preeclampsia.
Kulandavelu, S.; Dulce, R. A.; Murray, C. I.; Bellio, M. A.; Fritsch, J.; Kanashiro-Takeuchi, R.; Arora, H.; Paulino, E.; Soetkamp, D.; Balkan, W.; Van Eyk, J. E.; Hare, J. M.
10.1101/2020.07.01.183012 — physiology — Posted on 2021-06-21
1322 Glutamine deprivation triggers NAGK-dependent hexosamine salvage
Campbell, S. L.; Mesaros, C.; Izzo, L.; Affronti, H.; Tsang, T.; Noji, M.; Schaffer, B. E.; Sun, K.; Trefely, S.; Kruijning, S.; Blenis, J.; Blair, I. A.; Wellen, K. E.
10.1101/2020.09.13.294116 — cancer biology — Posted on 2021-06-21
1323 A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ
Lam, J.; Katti, P.; Biete, M.; Mungai, M.; AshShareef, S.; Neikirk, K.; Garza Lopez, E.; Vue, Z.; Christensen, T. A.; Beasley, H.; Rodman, T.; Salisbury, J. L.; Glancy, B.; Pereira, R. O.; Abel, E. D.; Hinton, A.
10.1101/2021.05.27.446036 — biophysics — Posted on 2021-06-21
1325 A Novel Local Ablation Approach for Explaining Multimodal Classifiers
Ellis, C. A.; Carbajal, D. A.; Zhang, R.; Sendi, M. S. E.; Miller, R. L.; Calhoun, V.; Wang, M. D.
10.1101/2021.06.10.447986 — bioinformatics — Posted on 2021-06-21
1326 Functional Molecular Switches of Mammalian G Protein-Coupled Bitter-Taste Receptors
Topin, J.; Bouysset, C.; Pacalon, J.; Kim, Y.; Rhyu, M.; Fiorucci, S.; Golebiowski, J.
10.1101/2020.10.23.348706 — bioinformatics — Posted on 2021-06-21
1328 SARS-CoV-2 activates ER stress and Unfolded protein response
Rosa-Fernandes, L.; Lazari, L. C.; Macedo-da-Silvia, J.; Gomes, V. d. M.; Machado, R. R. G.; dos Santos, A. F.; Araujo, D. B.; Coutinho, J. V. P.; Arini, G. S.; Angeli, C. B.; de Souza, E. E.; Wrenger, C.; Marinho, C. R. F.; Oliveira, D. B. L.; Durigon, E. L.; Labriola, L.; Palmisano, G.
10.1101/2021.06.21.449284 — biochemistry — Posted on 2021-06-21
1329 Deamidation of the human eye lens protein γS-crystallin accelerates oxidative aging
Norton-Baker, B.; Mehrabi, P.; Kwok, A. O.; Roskamp, K. W.; Spague-Piercy, M. A.; von Stetten, D.; Miller, R. J. D.; Martin, R. W.
10.1101/2021.06.21.449298 — biochemistry — Posted on 2021-06-21
1331 Moxidectin and ivermectin inhibit SARS-CoV-2 replication in Vero E6 cells but not in human primary airway epithelium cells
Dinesh Kumar, N.; ter Ellen, B. M.; Bouma, E. M.; Troost, B.; van de Pol, D. P. I.; van der Ende-Metselaar, H. H.; van Gosliga, D.; Apperloo, L.; Carpaij, O. A.; van den Berge, M.; Nawijn, M. C.; Stienstra, Y.; Rodenhuis-Zybert, I. A.; Smit, J.
10.1101/2021.05.17.444467 — microbiology — Posted on 2021-06-21
1332 Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection
Moses, M. E.; Hofmeyr, S.; Cannon, J. L.; Andrews, A.; Gridley, R.; Hinga, M.; Leyba, K.; Pribisova, A.; Surjadidjaja, V.; Tasnim, H.; Forrest, S.
10.1101/2021.05.19.444569 — immunology — Posted on 2021-06-21
1334 Oxidative stress is a potential cost of synchronous nesting in olive ridley sea turtles
Arango, B. G.; Harfush-Melendez, M.; Ensminger, D. C.; Lopez-Reyes, E. M.; Marmolejo-Valencia, J. A.; Merchant-Larios, H.; Crocker, D. E.; Vazquez-Medina, J. P.
10.1101/2021.06.21.449061 — physiology — Posted on 2021-06-21
1335 High-throughput microcolony growth analysis from suboptimal low-magnification micrographs
Plavskin, Y.; Li, S.; Jung, H.; Sartori, F. M. O.; Buzby, C.; Mueller, H.; Ziv, N.; Levy, S. F.; Siegal, M. L.
10.1101/253724 — bioinformatics — Posted on 2021-06-21
1337 A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
Hanke, L.; Das, H.; Sheward, D.; Perez Vidakovics, L.; Urgard, E.; Moliner Morro, A.; Changil, K.; Karl, V.; Pankow, A.; Smith, N.; Porebski, B.; Fernandez-Capetillo, O.; Sezgin, E.; Pedersen, G.; Coquet, J. M.; Hallberg, B. M.; Murrell, B.; McInerney, G. M.
10.1101/2021.03.20.436243 — immunology — Posted on 2021-06-21
1341 Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson's disease
Zarkali, A.; Luppi, A.; Stamatakis, E. A.; Reeves, S.; McColgan, P.; Leyland, L. A.; Lees, A. J.; Weil, R. S.
10.1101/2021.06.21.449237 — neuroscience — Posted on 2021-06-21
1342 The neurocomputational architecture of explore-exploit decision making
Hogeveen, J.; Mullins, T. S.; Romero, J.; Eversole, E.; Rogge-Obando, K.; Mayer, A. R.; Costa, V. D.
10.1101/2021.06.21.449128 — neuroscience — Posted on 2021-06-21
1344 A genotype independent DMP-HI system in dicot crops
Zhong, Y.; Chen, B.; Wang, D.; Zhu, X.; Wang, Y.; Li, M.; Li, Y.; Liu, J.; Zhang, J.; Chen, M.; Wang, M.; Riksen, T.; Qi, X.; Cheng, D.; Liu, Z.; Li, J.; Chen, C.; Jiao, Y.; Liu, W.; Yi, B.; Huang, S.; Liu, C.; Boutilier, K.; Chen, S.
10.1101/2021.06.21.449224 — plant biology — Posted on 2021-06-21
1346 The cardiac STAT3 intercalated disc specific expression in tail suspension rat
He, D.; Hu, A.; Tong, J.; Zheng, C.; Liu, Y.; Chen, Z.; Gao, L.; Wang, Y.
10.1101/2021.06.20.449202 — physiology — Posted on 2021-06-21
1349 Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor
Ma, S.; Chen, Y.; Dai, A.; Yin, W.; Guo, J.; Yang, D.; Zhou, F.; Jiang, Y.; Wang, M.-W.; Xu, H. E.
10.1101/2021.06.20.449193 — biophysics — Posted on 2021-06-21
1352 Assessing the utility of CASP14 models for molecular replacement
Millan, C.; Keegan, R. M.; Pereira, J.; Sammito, M. D.; Simpkin, A. J.; McCoy, A. J.; Lupas, A. N.; Hartmann, M. D.; Rigden, D. J.; Read, R. J.
10.1101/2021.06.21.449228 — bioinformatics — Posted on 2021-06-21
1353 Deposition chamber technology as building blocks for a standardized brain-on-chip framework
Maisonneuve, B. G. C.; Libralesso, L.; Miny, L.; Batut, A.; Rontard, J.; Gleyzes, M.; Boudra, B.; Vieira, J.; Debis, D.; Larramendy, F.; Jost, V.; Honegger, T.
10.1101/2021.06.21.449231 — bioengineering — Posted on 2021-06-21
1359 Dominant Effect Of Host Genetics On Skin Microbiota Composition In Homeostasis And Wound Healing
Galbraith, J.; Legrand, J.; Muller, N.; Baz, B.; Togher, K.; Matigian, N.; Kang, S.; Young, S.; Mortlock, S.; Roy, E.; Morahan, G.; Walker, G.; Morrison, M.; Khosrotehrani, K.
10.1101/2021.06.20.449197 — systems biology — Posted on 2021-06-21
1360 The gravitation-driven stress-reduced urothelial barrier in toad bladder urothelium
Tan, X.; Wang, D.; Fan, S.; Xu, X.; Guo, H.; Emmanuel, K. T.; Merveille, N. N. M.; Wang, Y.
10.1101/2021.06.20.449200 — physiology — Posted on 2021-06-21
1361 The PRMT7-dependent methylation of shank2 modulates invasion-proliferation switching during breast cancer metastasis
Liu, Y.; Liu, X.; Liu, L.; Wang, Y.; Peng, L.; Liu, J.; Li, L.; Zhang, L.; Wang, G.; Li, H.; Liu, D.; Huang, B.; Lu, J.; Zhang, Y.
10.1101/728410 — cancer biology — Posted on 2021-06-21
1362 Diverse tumorigenic consequences of human papillomavirus integration in primary oropharyngeal cancers
Symer, D. E.; Akagi, K.; Geiger, H. M.; Song, Y.; Li, G.; Emde, A.-K.; Xiao, W.; Jiang, B.; Li, J.; Agrawal, A. D.; Ozer, E.; El-Naggar, A. K.; Du, Z.; Shewale, J.; Stache-Crain, B.; Zucker, M.; Robine, N.; Coombes, K. R.; Gillison, M. L.
10.1101/2021.06.20.449168 — genomics — Posted on 2021-06-21
1364 Meiotic cell cycle progression requires adaptation to a constitutive DNA damage signal
Zhang, L.; Stauffer, W. T.; Ziesel, A.; Wang, J. S.; Yu, Z.; Hollingsworth, N. M.; Dernburg, A. F.
10.1101/2021.06.20.449183 — cell biology — Posted on 2021-06-21
1370 Natural selection promotes the evolution of recombination 1: among selected genotypes
Gerrish, P. J.; Galeota-Sprung, B. J.; Sniegowski, P. D.; Chevallier, J.; Ycart, B.
10.1101/2021.06.07.447320 — evolutionary biology — Posted on 2021-06-21
1373 The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult gut
Ramadan, R.; van Neerven, S. M.; Wouters, V. M.; Martins Garcia, T.; Muncan, V.; Franklin, O. D.; Battle, M.; Carlson, K. S.; Leach, J.; Sansom, O. J.; Vermeulen, L.; Medema, J. P.; Huels, D. J.
10.1101/2021.04.14.439776 — cell biology — Posted on 2021-06-21
1377 An extracellular redox signal triggers calcium release and impacts the asexual development of Toxoplasma gondii
Alves, E.; Benns, H. J.; Magnus, L.; Dominicus, C.; Dobai, T.; Blight, J.; Wincott, C. J.; Child, M. A.
10.1101/2021.02.04.429728 — microbiology — Posted on 2021-06-21
1378 Large-scale neural recordings with single-cell resolution in human cortex using high-density Neuropixels probes
Paulk, A. C.; Kfir, Y.; Khanna, A.; Mustroph, M.; Trautmann, E. M.; Soper, D. J.; Stavisky, S. D.; Welkenhuysen, M.; Dutta, B.; Shenoy, K. V.; Hochberg, L. R.; Richardson, M.; Williams, Z. M.; Cash, S. S.
10.1101/2021.06.20.449152 — neuroscience — Posted on 2021-06-21
1382 Progesterone receptor-A isoform interaction with RUNX transcription factors controls chromatin remodelling at promoters during ovulation
Dinh, T. D.; Breen, J.; Nicol, B.; Smith, K. M.; Nicholls, M.; Emery, A.; Wong, Y. Y.; Barry, S. C.; Yao, H. H.-C.; Robker, R. L.; Russell, D. L.
10.1101/2021.06.17.448908 — molecular biology — Posted on 2021-06-20
1387 MRP5 and MRP9 Play a Concerted Role in Male Reproduction and Mitochondrial Function
Chambers, I. G.; Kumar, P.; Lichtenberg, J.; Wang, P.; Yu, J.; Phillips, J.; Kane, M. A.; Bodine, D.; Hamza, I.
10.1101/2021.06.19.449033 — genetics — Posted on 2021-06-20
1389 The novel Rab5 effector FERRY links early endosomes with the translation machinery
Schuhmacher, J. S.; tom Dieck, S.; Christoforidis, S.; Landerer, C.; Hersemann, L.; Seifert, S.; Giner, A.; Toth-Petroczy, A.; Kalaidzidis, Y.; Schuman, E. M.; Zerial, M.
10.1101/2021.06.20.449167 — cell biology — Posted on 2021-06-20
1391 RPRD Proteins Control Transcription in Human Cells
Winczura, K.; Ceylan, H.; Sledziowska, M.; Jones, M.; Fagarasan, H.; Wang, J.; Saponaro, M.; Arnold, R.; Hebenstreit, D.; Grzechnik, P.
10.1101/2021.06.20.449126 — molecular biology — Posted on 2021-06-20
1394 Gaze-Related Activity in Primate Frontal Cortex Predicts and Mitigates Spatial Uncertainty
Bharmauria, V.; Schuetz, A.; Khoozani, P. A.; Yan, X.; Wang, H.; Bremmer, F.; Crawford, J. D.
10.1101/2021.06.20.449147 — neuroscience — Posted on 2021-06-20
1396 Localization of planteose hydrolysis during seed germination of Orobanche minor
Okazawa, A.; Baba, A.; Okano, H.; Tokunaga, T.; Nakaue, T.; Ogawa, T.; Shimma, S.; Sugimoto, Y.; Ohta, D.
10.1101/2021.06.16.448768 — plant biology — Posted on 2021-06-20
1398 3D structure and in situ arrangements of CatSper channel in the sperm flagellum
Zhao, Y.; Wang, H.; Wiesehoefer, C.; Shah, N. B.; Reetz, E.; Hwang, J. Y.; Huang, X.; Lishko, P. V.; Davies, K. M.; Wennemuth, G.; Nicastro, D.; Chung, J.-J.
10.1101/2021.06.19.448910 — biophysics — Posted on 2021-06-20
1399 A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion
Nadeem, A.; Nagampalli, R.; Toh, E.; Alam, A.; Myint, S. L.; Heidler, T. V.; Dongre, M.; Zlatkov, N.; Pace, H.; Bano, F.; Sjostedt, A.; Bally, M.; Uhlin, B. E.; Wai, S. N.; Persson, K.
10.1101/2021.06.20.449157 — biochemistry — Posted on 2021-06-20
1405 The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation
Khandelwal, N. K.; Millan, C. R.; Zangari, S. I.; Avila, S.; Williams, D.; Thaker, T. M.; Tomasiak, T. M.
10.1101/2021.06.18.449046 — biochemistry — Posted on 2021-06-20
1409 BehaviorDEPOT: a tool for automated behavior classification and analysis in rodents
Gabriel, C. J.; Zeidler, Z.; Jin, B.; Guo, C.; Wu, A.; Aharoni, D.; Wilke, S. A.; DeNardo, L. A.
10.1101/2021.06.20.449150 — neuroscience — Posted on 2021-06-20
1418 Disruption of VGLUT1 in cholinergic medial habenula projections increases nicotine self-administration
Souter, E. A.; Chen, Y.-C.; Zell, V.; Lallai, V.; Steinkellner, T.; Conrad, W. S.; Wisden, W.; Harris, K. D.; Fowler, C. D.; Hnasko, T. S.
10.1101/2021.06.19.449108 — neuroscience — Posted on 2021-06-20
1428 Photoreactive hydrogel stiffness influences volumetric muscle loss repair
Basurto, I. M.; Passipieri, J. A.; Gardner, G. M.; Smith, K. K.; Amacher, A. R.; Hansrisuk, A. I.; Christ, G. J.; Caliari, S. R.
10.1101/2021.06.19.449065 — bioengineering — Posted on 2021-06-20
1430 Supervised Learning Model Predicts Protein Adsorption to Nanotubes
Pinals, R. L.; Ouassil, N.; Del Bonis-O'Donnell, J. T.; Wang, J. W.; Landry, M. P.
10.1101/2021.06.19.449132 — bioengineering — Posted on 2021-06-20
1431 A Novel Membrane Protein in the Rhodobacter sphaeroides LH1-RC Photocomplex
Tani, K.; Nagashima, K. V. P.; Kanno, R.; Kawamura, S.; Kikuchi, R.; Hall, M.; Yu, L.- J.; Kimura, Y.; Madigan, M. T.; Mizoguchi, A.; Humbel, B. M.; Wang-Otomo, Z.- Y.
10.1101/2021.06.20.449127 — biochemistry — Posted on 2021-06-20
1432 A compendium of novel genomics technologies provides a chromosome-scale assembly and insights into the sex determining system of the Greenland Halibut
Ferchaud, A.-L.; Merot, C.; Normandeau, E.; Ragoussis, I.; Babin, C.; Djambazian, H.; Berube, P.; Audet, C.; Walkusz, W.; Treble, M.; Bernatchez, L.
10.1101/2021.06.18.449053 — genomics — Posted on 2021-06-20
1433 MRP5 and MRP9 Play a Concerted Role in Male Reproduction and Mitochondrial Function
Chambers, I. G.; Kumar, P.; Lichtenberg, J.; Wang, P.; Yu, J.; Phillips, J.; Kane, M. A.; Bodine, D.; Hamza, I.
10.1101/2021.06.19.449033 — genetics — Posted on 2021-06-20
1434 Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling
LIU, X.; Bae, C.; Liu, B.; Zhang, Y.; Zhou, X.; Yamaguchi, T. P.; Chung, J. M.; Tang, S.-J.
10.1101/2021.06.19.449129 — neuroscience — Posted on 2021-06-20
1436 Do we really understand the role of the prefrontal cortex in placebo analgesia?
Frangos, E.; Madian, N.; Wang, B.; Bradson, M. L.; Gracely, J. L.; Richards, E. A.; Colloca, L.; Schweinhardt, P.; Bushnell, M. C.; Ceko, M.
10.1101/2021.06.18.449012 — neuroscience — Posted on 2021-06-20
1438 Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia
Chun, B. J.; Aryal, S.; Sun, B.; Bruno, J.; Richards, C.; Bachstetter, A. D.; Kekenes-Huskey, P. M.
10.1101/2021.06.19.448892 — physiology — Posted on 2021-06-20
1439 Linking Parasitism to Network Centrality and the Impact of Sampling Bias in its Interpretation
XU, Z.; MacIntosh, A. J. J.; Castellano-Navarro, A.; Macanas-Martuinez, E.; Suzumura, T.; Duboscq, J.
10.1101/2021.06.07.447302 — animal behavior and cognition — Posted on 2021-06-20
1440 SpotClean adjusts for spot swapping in spatial transcriptomics data
Ni, Z.; Prasad, A.; Chen, S.; Halberg, R. B.; Arkin, L.; Drolet, B.; Newton, M.; Kendziorski, C.
10.1101/2021.06.11.448105 — genomics — Posted on 2021-06-20
1441 Homogenization of a Reaction Diffusion Equation can Explain Influenza A Virus Load Data
Baabdulla, A. A.; Park, J. A.; Now, H.; Kim, W.-J.; Jung, S.; Yoo, J.-Y.; Hillen, T.
10.1101/2021.01.04.425332 — microbiology — Posted on 2021-06-20
1444 In situ X-ray assisted electron microscopy staining for large biological samples
Ströh, S.; Hammerschmith, E. W.; Tank, D. W.; Seung, H. S.; Wanner, A. A.
10.1101/2021.06.19.448808 — neuroscience — Posted on 2021-06-20
1445 NPEPPS regulates intracellular import and sensitivity to cisplatin by interaction with volume regulated anion channels
Jones, R. T.; Goodspeed, A.; Akbarzadeh, M. C.; Scholtes, M.; Vekony, H.; Jean, A.; Tilton, C. B.; Mohapatra, S.; Orman, M. V.; Araki, S.; Joshi, M.; Laajala, T. D.; Javaid, M.; Clambey, E. T.; Layer, R.; Parker, S.; Mahmoudi, T.; Zuiverloon, T.; Theodorescu, D.; Costello, J. C.
10.1101/2021.03.04.433676 — cancer biology — Posted on 2021-06-19
1446 A framework for evaluating the performance of SMLM cluster analysis algorithms
Nieves, D. J.; Pike, J. A.; Levet, F.; Griffie, J.; Sage, D.; Cohen, E. A. K.; Sibarita, J.-B.; Heilemann, M.; Owen, D. M.
10.1101/2021.06.19.449098 — biophysics — Posted on 2021-06-20
1452 Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration
Choi, J.; Jang, Y. J.; Dabrowska, C.; Iich, E.; Evans, K.; Hall, H.; Janes, S. M.; Simons, B. D.; Koo, B.-K.; Kim, J.; Lee, J.-H.
10.1101/2021.06.19.449004 — cell biology — Posted on 2021-06-19
1455 The percentage of Monocytes CD39+ is higher in Pregnant COVID-19 than in Non-Pregnant COVID-19 patients
Cerbulo-Vazquez, A.; Garcia-Espinosa, M.; Briones-Garduno, J. C.; Arriaga-Pizano, L. A.; Ferat-Osorio, E.; Zavala-Barrios, B.; Cabrera-Rivera, G. L.; Miranda-Cruz, P.; Garcia de la Rosa, M. T.; Prieto-Chavez, J. L.; Rivero-Arredondo, V.; Madera-Sandoval, R. L.; Cruz-Cruz, A.; Salazar-Rios, E.; Salazar-Rios, M. E.; Serrano-Molina, D.; De Lira-Barraza, R. C.; Villanueva-Compean, A. H.; Esquivel-Pineda, A.; Ramirez-Montes de Oca, R.; Caldino-Soto, F.; Ramirez-Garcia, L. A.; Flores-Padilla, M. G.; Moreno-Alvarez, O.; Guerrero-Avendano, G. M. L.; Lopez-Macias, C.
10.1101/2021.06.18.449054 — immunology — Posted on 2021-06-19
1456 Differences in IgG antibody responses following BNT162b2 and mRNA-1273 Vaccines
Montoya, J. G.; Adams, A. E.; Bonetti, V.; Deng, S.; Link, N. A.; Pertsch, S.; Olson, K.; Li, M.; Dillon, E. C.; Frosch, D. L.
10.1101/2021.06.18.449086 — immunology — Posted on 2021-06-19
1457 Tracking the Brain's Intrinsic Connectivity Networks in EEG
Shaw, S. B.; McKinnon, M. C.; Heisz, J. J.; Harrison, A. H.; Connolly, J. F.; Becker, S.
10.1101/2021.06.18.449078 — neuroscience — Posted on 2021-06-19
1458 EcoEvoApps: Interactive Apps for Teaching Theoretical Models in Ecology and Evolutionary Biology
McGuire, R. M.; Hayashi, K. T.; Yan, X.; Cowen, M. C.; Carita Vaz, M.; Sullivan, L. L.; Kandlikar, G. S.
10.1101/2021.06.18.449026 — scientific communication and education — Posted on 2021-06-19
1459 WWP1 deficiency protects from cardiac remodeling induced by simulated microgravity
Zhong, G.; Zhao, D.; Li, J.; Liu, Z.; Pan, J.; Yuan, X.; Xing, W.; Zhao, Y.; Ling, S.; Li, Y.
10.1101/2021.06.18.447041 — physiology — Posted on 2021-06-19
1461 Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with Pol α - Primase
Kilkenny, M. L.; Veale, C. E.; Guppy, A.; Hardwick, S. W.; Chirgadze, D. Y.; Rzechorzek, N. J.; Maman, J. D.; Pellegrini, L.
10.1101/2021.06.17.448816 — biophysics — Posted on 2021-06-19
1462 Discovery of SARS-CoV-2 Mpro Peptide Inhibitors from Modelling Substrate and Ligand Binding
Chan, H. T. H.; Moesser, M. A.; Walters, R. K.; Malla, T. R.; Twidale, R. M.; John, T.; Deeks, H. M.; Johnston-Wood, T.; Mikhailov, V.; Sessions, R. B.; Dawson, W.; Salah, E.; Lukacik, P.; Strain-Damerell, C.; Owen, D.; Nakajima, T.; Swiderek, K.; Lodola, A.; Moliner, V.; Glowacki, D. R.; Walsh, M. A.; Schofield, C. J.; Genovese, L.; Shoemark, D.; Mulholland, A. J.; Duarte, F.; Morris, G. M.
10.1101/2021.06.18.446355 — bioinformatics — Posted on 2021-06-19
1463 Mapping the host protein interactome of non-coding regions in SARS-CoV-2 genome
Jiang, L.; Xiao, M.; Liao, Q.-Q.; Zheng, L.; Li, C.; Liu, Y.; Yang, B.; Ren, A.; Jiang, C.; Feng, X.-H.
10.1101/2021.06.19.449092 — genomics — Posted on 2021-06-19
1464 Impact of genomic preselection on subsequent genetic evaluations with ssGBLUP - using real data from pigs
Jibrila, I.; Vandenplas, J.; ten Napel, J.; Bergsma, R.; Veerkamp, R. F.; Calus, M. P. L.
10.1101/2021.06.18.449002 — genetics — Posted on 2021-06-19
1467 A method to study extracellular vesicles secreted in vitro by cultured cells with minimum sample processing and extracellular vesicle loss
Viveiros, A.; Kadam, V. P.; Monyror, J.; Morales, L. C.; Pink, D.; Rieger, A. R.; Sipione, S. P.; Posse de Chaves, E. P.
10.1101/2021.06.18.447964 — cell biology — Posted on 2021-06-19
1470 Sequencing using a two-steps strategy reveals high genetic diversity in the S gene of SARS-CoV-2 after a high transmission period in Tunis, Tunisia.
Fares, W.; Ghedira, K.; Gdoura, M.; Chouikha, A.; Haddad-Boubaker, S.; Khediri, M.; Ayouni, K.; Lamari, A.; Touzi, H.; Hammemi, W.; Medeb, Z.; Sadraoui, A.; Hogga, N.; Ben Aleya, N.; Triki, H.
10.1101/2021.06.18.449083 — microbiology — Posted on 2021-06-19
1474 Measles fusion complexes from central nervous system clinical isolates: decreased interaction between hemagglutinin and fusion proteins
Mathieu, C.; Nascimento Figueira, T.; Decker, A. R.; Ferren, M.; Bovier, F. T.; Jurgens, E. M.; Marcink, T. C.; Moscona, A.; Porotto, M.
10.1101/2021.06.18.449082 — microbiology — Posted on 2021-06-19
1475 SARS-CoV-2 mRNA Vaccine Induces Robust Specific and Cross-reactive IgG and Unequal Strain-specific Neutralizing Antibodies in Naïve and Previously Infected Recipients
Narowski, T. M.; Raphel, K.; Adams, L. E.; Huang, J.; Vielot, N. A.; Jadi, R.; de Silva, A. M.; Baric, R. S.; Lafleur, J. E.; Premkumar, L.
10.1101/2021.06.19.449100 — immunology — Posted on 2021-06-19
1477 Requirement for an Otopetrin-Like protein for acid taste in Drosophila
Ganguly, A.; Chandel, A.; Turner, H.; Wang, S.; Liman, E. R.; Montell, C.
10.1101/2021.06.18.449071 — neuroscience — Posted on 2021-06-19
1479 Immune-evasion of KRAS-mutant lung adenocarcinoma mediated by cAMP response element-binding protein
Giotopoulou, G. A.; Ntaliarda, G.; Marazioti, A.; Lilis, I.; Kalogianni, F.; Tourkochristou, E.; Spiropoulou, N.; Giopanou, I.; Spella, M.; Iliopoulou, M.; Korfiati, A.; Mantamadiotis, T.; Rosero, C.; Goldmann, T.; Marwitz, S.; Stathopoulos, G. T.
10.1101/2021.06.19.449094 — cancer biology — Posted on 2021-06-19
1480 Pathway-based approach reveals differential sensitivity of glioblastoma to E2F1 inhibition
Alvarado, A. G.; Tessema, K.; Muthukrishnan, S. D.; Sober, M.; Kawaguchi, R.; Bhaduri, A.; Swarup, V.; Nathanson, D. A.; Goldman, S. A.; Kornblum, H. I.
10.1101/2021.06.19.449118 — cancer biology — Posted on 2021-06-19
1484 A dose-sensitive OGT-TET3 complex is necessary for normal Xist RNA distribution and function
Martin, E. A.; Maynard, J. C.; Hrit, J.; Augspurger, K.; Picard, C. L.; Feng, S.; Jacobsen, S. E.; Burlingame, A.; Panning, B.
10.1101/2021.06.19.449113 — genetics — Posted on 2021-06-19
1486 Define protein variant functions with high-complexity mutagenesis libraries and enhanced mutation detection software ASMv1.0
Yang, X.; Hong, A. L.; Sharpe, T.; Giacomelli, A. O.; Lintner, R. E.; Alan, D.; Green, T.; Hayes, T. K.; Piccioni, F.; Fritchman, B.; Kawabe, H.; Sawyer, E.; Sprenkle, L.; Lee, B. P.; Persky, N. S.; Brown, A.; Greulich, H.; Aguirre, A. J.; Meyerson, M.; Hahn, W. C.; Johannessen, C. M.; Root, D. E.
10.1101/2021.06.16.448102 — systems biology — Posted on 2021-06-19
1489 The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation
Khandelwal, N. K.; Millan, C. R.; Zangari, S. I.; Avila, S.; Williams, D.; Thaker, T. M.; Tomasiak, T. M.
10.1101/2021.06.18.449046 — biochemistry — Posted on 2021-06-19
1490 CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc
Jalal, A. S. B.; Tran, N. T.; Wu, L. J.; Ramakrishnan, K.; Rejzek, M.; Gobbato, G.; Stevenson, C. E. M.; Lawson, D. M.; Errington, J.; Le, T. B. K.
10.1101/2021.02.11.430593 — microbiology — Posted on 2021-06-19
1492 Pore structure controls stability and molecular flux in engineered protein cages
Adamson, L. S. R.; Tasneem, N.; Andreas, M. P.; Close, W.; Jenner, E. N.; Szyszka, T. N.; Young, R.; Cheah, L. C.; Norman, A.; MacDermott-Opeskin, H. I.; O'Mara, M. L.; Sainsbury, F.; Giessen, T. W.; Lau, Y. H.
10.1101/2021.01.27.428512 — synthetic biology — Posted on 2021-06-19
1497 Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1
Magistrati, E.; Maestrini, G.; Lince-Faria, M.; Beznoussenko, G.; Mironov, A.; Maspero, E.; Bettencourt Dias, M.; Polo, S.
10.1101/2021.06.18.448975 — cell biology — Posted on 2021-06-19
1499 Claustral Projections to Anterior Cingulate Cortex Modulate Engagement with the External World
Atlan, G.; Matosevich, N.; Peretz-Rivlin, N.; Yvgi, I.; Chen, E.; Kleinman, T.; Bleistein, N.; Sheinbach, E.; Groysman, M.; Nir, Y.; Citri, A.
10.1101/2021.06.17.448649 — neuroscience — Posted on 2021-06-19
1500 Define protein variant functions with high-complexity mutagenesis libraries and enhanced mutation detection software
Yang, X.; Hong, A. L.; Sharpe, T.; Giacomelli, A. O.; Lintner, R. E.; Alan, D.; Green, T.; Hayes, T. K.; Piccioni, F.; Fritchman, B.; Kawabe, H.; Sawyer, E.; Sprenkle, L.; Lee, B. P.; Persky, N. S.; Brown, A.; Greulich, H.; Aguirre, A. J.; Meyerson, M.; Hahn, W. C.; Johannessen, C. M.; Root, D. E.
10.1101/2021.06.16.448102 — systems biology — Posted on 2021-06-19
1501 SLIMP: Supervised learning of metabolite-protein interactions from co-fractionation mass spectrometry data
Zühlke, B. M.; Sokolowska, E. M.; Luzarowski, M.; Schlossarek, D.; Chodasiewicz, M.; Leniak, E.; Skirycz, A.; Nikoloski, Z.
10.1101/2021.06.16.448636 — systems biology — Posted on 2021-06-19
1508 Fast alignment and preprocessing of chromatin profiles with Chromap
Zhang, H.; Song, L.; Wang, X.; Cheng, H.; Wang, C.; Meyer, C.; Liu, T.; Tang, M.; Aluru, S.; Yue, F.; Liu, X. S.; Li, H.
10.1101/2021.06.18.448995 — bioinformatics — Posted on 2021-06-18
1510 GRAND: A database of gene regulatory network models across human conditions
Ben Guebila, M.; Lopes-Ramos, C. M.; Weighill, D.; Sonawane, A.; Burkholz, R.; Shamsaei, B.; Platig, J.; Glass, K.; Kuijjer, M. L.; Quackenbush, J.
10.1101/2021.06.18.448997 — genomics — Posted on 2021-06-18
1511 The SAGA core module is critical during Drosophila oogenesis and is broadly recruited to promoters
Soffers, J. H.; Garcia-Moreno Alcantara, S.; Li, X.; Shao, W.; Seidel, C.; Li, H.; Zeitlinger, J.; Abmayr, S.; Workman, J.
10.1101/2021.06.18.448946 — genomics — Posted on 2021-06-18
1513 Single nucleus pituitary transcriptomic and epigenetic landscape reveals human stem cell heterogeneity with diverse regulatory mechanisms
Zhang, Z.; Zamojski, M.; Smith, G. R.; Willis, T. L.; Yianni, V.; Mendelev, N.; Pincase, H.; Seenarine, N.; Amper, M. A. S.; Vasoya, M.; Nair, V.; Turgeon, J. L.; Bernard, D. J.; Troyanskaya, O. G.; Andoniadou, C. L.; Sealfon, S. C.; Ruf-Zamojski, F. M.
10.1101/2021.06.18.449034 — cell biology — Posted on 2021-06-18
1519 Binary Interactome Models of Inner- Versus Outer-Complexome Organization
Lambourne, L.; Yadav, A.; Wang, Y.; Desbuleux, A.; Kim, D.-K.; Cafarelli, T.; Pons, C.; Kovacs, I. A.; Jailkhani, N.; Schlabach, S.; De Ridder, D.; Luck, K.; Bian, W.; Shen, Y.; Mee, M. W.; Helmy, M.; Jacob, Y.; Lemmens, I.; Rolland, T.; Cote, A. G.; Gebbia, M.; Kishore, N.; Knapp, J. J.; Mellor, J. C.; Reimand, J.; Tavernier, J.; Cusick, M. E.; Falter-Braun, P.; Spirohn, K.; Zhong, Q.; Aloy, P.; Hao, T.; Charloteaux, B.; Roth, F. P.; Hill, D. E.; Calderwood, M. A.; Twizere, J.-C.; Vidal, M.
10.1101/2021.03.16.435663 — systems biology — Posted on 2021-06-18
1520 Resetting of the 24-nt siRNA landscape in rice zygotes
Li, C.; Gent, J. I.; Xu, H.; Fu, H.; Russell, S. D.; Sundaresan, V.
10.1101/2020.08.31.275958 — plant biology — Posted on 2021-06-18
1522 Tumor PD-L1 selectively suppresses type I interferon in myeloid cells to suppress CTL recruitment to promote lung metastasis
Klement, J. D.; Redd, P. S.; Lu, C.; Merting, A. D.; Poschel, D. B.; Yang, D.; Zhou, G.; Munn, D. H.; Liu, K.
10.1101/2021.06.18.449028 — cancer biology — Posted on 2021-06-18
1526 The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation
Khandelwal, N. K.; Millan, C. R.; Zangari, S. I.; Avila, S.; Williams, D.; Thake, T. M. r.; Tomasiak, T. M.
10.1101/2021.06.18.449046 — biochemistry — Posted on 2021-06-18
1527 A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers
Hwang, T.; Parker, S. S.; Hill, S. M.; Ilunga, M. W.; Grant, R. A.; Mouneimne, G.; Keating, A. E.
10.1101/2021.05.27.445944 — biochemistry — Posted on 2021-06-18
1529 Stability of Polygenic Scores Across Discovery Genome-Wide Association Studies
Schultz, L. M.; Merikangas, A. K.; Ruparel, K.; Jacquemont, S.; Glahn, D. C.; Gur, R. E.; Barzilay, R.; Almasy, L.
10.1101/2021.06.18.449060 — genetics — Posted on 2021-06-18
1533 Fungal community turnover along steep environmental gradients from geothermal soils in Yellowstone National Park
Bazzicalupo, A.; Erlandson, S.; Branine, M.; Ratz, M.; Ruffing, L.; Nguyen, N. H.; Branco, S.
10.1101/2021.04.06.438641 — ecology — Posted on 2021-06-18
1534 Lamellipodia-like actin networks in cells lacking WAVE Regulatory Complex
Kage, F.; Doering, H.; Mietkowska, M.; Schaks, M.; Gruener, F.; Stahnke, S.; Steffen, A.; Muesken, M.; Stradal, T. E. B.; Rottner, K.
10.1101/2021.06.18.449030 — cell biology — Posted on 2021-06-18
1535 Stem cell-free therapy for glaucoma to preserve vision
Kumar, A.; Xiong, S.; Zhou, M.; Chen, W.; Yang, E.; Price, A.; Le, L.; Zhang, Y.; Florens, L.; Washburn, M.; Kumar, A.; Li, Y.; Xu, Y.; Lathrop, K. L.; Davoli, K. A.; Chen, Y.; Schuman, J. S.; Xie, T.; Du, Y.
10.1101/2021.06.18.449038 — cell biology — Posted on 2021-06-18
1537 Mouse oocytes do not contain a Balbiani body
Dhandapani, L.; Salzer, M. C.; Duran, J. M.; Zaffagnini, G.; De Guirior, C.; Martinez-Zamora, M. A.; Boke, E.
10.1101/2021.02.01.429160 — cell biology — Posted on 2021-06-18
1538 Splice Factor Polypyrimidine tract-binding protein 1 (Ptbp1) is Required for Immune Priming of the Endothelium in Atherogenic Disturbed Flow Conditions
Hensel, J. A.; Nicholas, S.-A. E.; Jellison, E. R.; Kimble, A. L.; Menoret, A.; Ozawa, M.; Rodriguez-Oquendo, A.; Vella, A. T.; Murphy, P. A.
10.1101/2021.06.18.449062 — cell biology — Posted on 2021-06-18
1539 Catchet-MS identifies IKZF1-targeting Thalidomide analogues as novel HIV-1 latency reversal agents
Ne, E.; Crespo, R.; Izquierdo-Lara, R.; Kocer, S.; Gorszka, A.; van Staveren, T.; Kan, T. W.; Dekkers, D. H. W.; Rokx, C.; Moulos, P.; Hatzis, P.; Palstra, R.-J.; Demmers, J. A.; Mahmoudi, T.
10.1101/2021.03.19.436149 — molecular biology — Posted on 2021-06-18
1540 FMO rewires metabolism to promote longevity throughtryptophan and one carbon metabolism
Choi, H. S.; Bhat, A.; Howington, M. B.; Schaller, M. L.; Cox, R.; Huang, S.; Beydoun, S.; Miller, H. A.; Tuckowski, A. M.; Mecano, J.; Dean, E. S.; Jensen, L.; Beard, D. A.; Evans, C. R.; Leiser, S. F.
10.1101/2021.06.18.449022 — molecular biology — Posted on 2021-06-18
1541 Morphogenesis and cell ordering in confined bacterial biofilms
Zhang, Q.; Li, J.; Nijjer, J.; Lu, H.; Kothari, M.; Alert, R.; Cohen, T.; Yan, J.
10.1101/2021.02.17.431682 — microbiology — Posted on 2021-06-18
1542 Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917
Gelfat, I.; Aqeel, Y.; Tremblay, J. M.; Jaskiewicz, J.; Shrestha, A.; Lee, J. N.; Hu, S.; Qian, X.; Magoun, L.; Sheoran, A.; Bedenice, D.; Giem, C.; Manjula-Basavanna, A.; Osbourne, M. S.; Tzipori, S.; Shoemaker, C. B.; Leong, J. M.; Joshi, N. S.
10.1101/2021.06.18.448998 — microbiology — Posted on 2021-06-18
1543 Metabolomic signature of the maternal microbiota in the fetus
Pessa-Morikawa, T.; Husso, A.; Kärkkäinen, O.; Koistinen, V.; Hanhineva, K.; Iivanainen, A.; Niku, M.
10.1101/2020.09.28.317081 — microbiology — Posted on 2021-06-18
1544 Creation of a single cell RNA seq meta-atlas to define human liver immune homeostasis
Rocque, B. L.; Barbetta, A.; Singh, P.; Goldbeck, C.; Helou, D. G.; Loh, Y.-H. E.; Ung, N.; Lee, J.; Akbari, O.; Emamaullee, J.
10.1101/2021.02.12.430976 — immunology — Posted on 2021-06-18
1545 Bioluminescent Genetically Encoded Glutamate Indicator for Molecular Imaging of Neuronal Activity
Petersen, E. D.; Crespo, E. L.; Lambert, G. G.; Zanca, A. T.; Orcutt, R.; Hochgeschwender, U.; Shaner, N. C.; Gilad, A.
10.1101/2021.06.16.448690 — neuroscience — Posted on 2021-06-18
1546 Introgression of type-IV glandular trichomes from Solanum galapagense to cultivated tomato reveals genetic complexity for the development of acylsugar-based insect resistance
Vendemiatti, E.; Therezan, R.; Vicente, M. H.; de Siqueira Pinto, M.; Bergau, N.; Yang, L.; Bernardi, W. F.; Matias de Alencar, S.; Zsogon, A.; Tissier, A.; Benedito, V.; Peres, L.
10.1101/2021.06.18.448858 — plant biology — Posted on 2021-06-18
1550 RPAP2 regulates a transcription initiation checkpoint by prohibiting assembly of preinitiation complex
Chen, X.; Qi, Y.; Wang, X.; Wang, Z.; Wang, L.; Song, A.; Li, J.; Zhao, D.; Zhang, H.; Jin, Q.; Chen, F. X.; Xu, Y.
10.1101/2021.06.18.448918 — molecular biology — Posted on 2021-06-18
1552 Structure and computation-guided design of a mutation-integrated trimeric RBD candidate vaccine with broad neutralization against SARS-CoV-2
Liang, Y.; Zhang, J.; Yuan, R. Y.; Wang, M. Y.; He, P.; Su, J. G.; Han, Z. B.; Jin, Y. Q.; Hou, J. W.; Zhang, H.; Zhang, X. F.; Shao, S.; Hou, Y. N.; Liu, Z. M.; Du, L. F.; Shen, F. J.; Zhou, W. M.; Tang, F.; Lei, Z. H.; Liu, S.; Zhen, W.; Wu, J. J.; Zheng, X.; Liu, N.; Chen, S.; Ma, Z. J.; Zheng, F.; Ren, S. Y.; Hu, Z. Y.; Wu, G. Z.; Huang, W. J.; Ke, C. W.; Li, Q. M.
10.1101/2021.06.18.448958 — immunology — Posted on 2021-06-18
1556 The Caenorhabditis elegans TDRD5/7-like protein, LOTR-1, interacts with the helicase ZNFX-1 to balance epigenetic signals in the germline
Marnik, E. A.; Almeida, M. V.; Cipriani, P. G.; Chung, G.; Caspani, E.; Karaulanov, E.; Butter, F.; Sharp, C. S.; Zinno, J.; Gan, H. H.; Piano, F.; Ketting, R.; Gunsalus, K.; Updike, D. L.
10.1101/2021.06.18.448978 — developmental biology — Posted on 2021-06-18
1560 No evidence of SARS-CoV-2 infection in Neotropical Primates sampled during COVID-19 pandemic in Minas Gerais and Rio Grande do Sul, Brazil.
Abreu, F. V. S. d.; Macedo, M. V.; Silva, A. J. J. d.; Oliveira, C. H. d.; Ottone, V. d. O.; Almeida, M. A. B. d.; Santos, E. d.; Cardoso, J. D. C.; Campos, A. S.; Silva, C. M. D. d.; Silva, A. G. d.; Andrade, M. d. S.; Bernis, V. M. O.; Bernis Filho, W. O.; Trindade, G. d. S.; Albuquerque, G. R.; Seva, A. d. P.; Ribeiro, B. M.; Teixeira, D. S.; Campos, F. S.; Franco, A. C.; Roehe, P. M.; Oliveira, D. B. d.
10.1101/2021.06.17.448890 — microbiology — Posted on 2021-06-18
1561 A novel bivalent DNA vaccine encoding both spike protein receptor-binding domain and nucleocapsid protein of SARS-CoV-2 to elicit T cell and neutralising antibody responses that cross react with variants
Brentville, V. A.; Vankemmelbeke, M.; Methingham, R. L.; Symonds, P.; Cook, K. W.; Urbanowicz, R. A.; Tsoleridis, T.; Coleman, C. M.; Chang, K.-C.; Skinner, A.; Dubinina, E.; Daniels, I.; Shah, S.; Dixon, J. E.; Pockley, A. G.; Adams, S. E.; Paston, S. J.; Daly, J. M.; Ball, J. K.; Durrant, L. G.
10.1101/2021.06.18.448932 — immunology — Posted on 2021-06-18
1562 Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients
Rausch, L.; Lutz, K.; Schifferer, M.; Winheim, E.; Gruber, R.; Rinke, L.; Hellmuth, J.; Scheerer, C.; Muenchhoff, M.; Mandel, C.; Bergwelt-Baildon, M.; Simons, M.; Straub, T.; Krug, A. B.; Kranich, J.; Brocker, T.
10.1101/2021.06.18.448935 — immunology — Posted on 2021-06-18
1563 Probing Affinity, Avidity, Anti-Cooperativity, and Competition in Antibody and Receptor Binding to the SARS-CoV-2 Spike by Single Particle Mass Analyses
Yin, V. C.; Lai, S.-H.; Caniels, T. G.; Brouwer, P. J. M.; Brinkkemper, M.; Aldon, Y.; Liu, H.; Yuan, M.; Wilson, I. A.; Sanders, R. W.; van Gils, M.; Heck, A. J. R.
10.1101/2021.06.18.448939 — immunology — Posted on 2021-06-18
1564 Stromal cell sialylation suppresses T cells in inflammatory tumour microenvironments: A new tumour stromal cell immune checkpoint?
Egan, H.; Treacy, O.; Lynch, K.; Leonard, N. A.; O'Malley, G.; DeVeirman, K.; Vanderkerken, K.; Craughwell, M.; Egan, L. J.; Ritter, T.; Hogan, A. M.; Redmond, K.; Sheehan, M.; Canney, A.; Hynes, S.; Kerr, E. M.; Dunne, P. D.; O'Dwyer, M. E.; Ryan, A. E.
10.1101/2021.06.18.447879 — immunology — Posted on 2021-06-18
1566 After traumatic brain injury oligodendrocytes regain a plastic phenotype and can become astrocytes
Bai, X.; Zhao, N.; Huang, W.; Caudal, L.; Zhao, R.; Hirrlinger, J.; Walz, W.; Kirchhoff, F.; Scheller, A.
10.1101/2021.06.18.448919 — neuroscience — Posted on 2021-06-18
1568 Identification of SGLT2 inhibitor Ertugliflozin as a treatment for COVID-19 using computational and experimental paradigm
Saxena, S.; Meher, K.; Rotella, M.; Vangala, S.; Chandran, S.; Malhotra, N.; Palakodeti, R.; Voleti, S.; Saxena, U.
10.1101/2021.06.18.448921 — pharmacology and toxicology — Posted on 2021-06-18
1569 Notch1 mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth
Abby, E.; Dentro, S. C.; Hall, M. W. J.; Fowler, J. C.; Ong, S. H.; Sood, R.; Siebel, C. W.; Gerstung, M.; Hall, B. A.; Jones, P.
10.1101/2021.06.18.448956 — cancer biology — Posted on 2021-06-18
1571 Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome
Bacic, L.; Gaullier, G.; Sabantsev, A.; Lehmann, L.; Brackmann, K.; Dimakou, D.; Halic, M.; Hewitt, G.; Boulton, S. J.; Deindl, S.
10.1101/2021.06.18.448936 — biophysics — Posted on 2021-06-18
1572 BioProfiling.jl: Profiling biological perturbations with high-content imaging in single cells and heterogeneous populations
Vulliard, L.; Hancock, J.; Kamnev, A.; Fell, C. W.; Ferreira da Silva, J.; Loizou, J.; Nagy, V.; Dupre, L.; Menche, J.
10.1101/2021.06.18.448961 — bioinformatics — Posted on 2021-06-18
1574 Multiplexed bioluminescence microscopy via phasor analysis
Yao, Z.; Brennan, C. K.; Scipioni, L.; Chen, H.; Ng, K.; Digman, M.; Prescher, J. A.
10.1101/2021.06.18.448905 — bioengineering — Posted on 2021-06-18
1578 A mutational gradient drives somatic mutation accumulation in mitochondrial DNA and influences germline polymorphisms and genome composition
Sanchez-Contreras, M.; Sweetwyne, M. T.; Kohrn, B. F.; Tsantilas, K. A.; Fredrickson, J.; Whitson, J. A.; Campbell, M. D.; Hurley, J. B.; Rabinovitch, P. S.; Marcinek, D. J.; Kennedy, S. R.
10.1101/2021.06.18.448725 — genomics — Posted on 2021-06-18
1580 Zebrafish Cre/lox regulated UFlip alleles generated by CRISPR/Cas targeted integration provide cell-type specific conditional gene inactivation
Almeida, M. P.; Kambakam, S.; Liu, F.; Ming, Z.; Welker, J. M.; Wierson, W. A.; Schultz-Rogers, L. E.; Ekker, S. C.; Clark, K. J.; Essner, J. J.; McGrail, M.
10.1101/2021.06.18.448732 — genetics — Posted on 2021-06-18
1584 Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease
Rovelet-Lecrux, A.; Feuillette, S.; Miguel, L.; Schramm, C.; Pernet, S.; Segalas-Milazzo, I.; Guilhaudis, L.; Rousseau, S.; Riou, G.; Frebourg, T.; Campion, D.; Nicolas, G.; Lecourtois, M.
10.1101/2021.06.18.448296 — cell biology — Posted on 2021-06-18
1588 Estimates of persistent inward currents are reduced in upper limb motor units of older adults
Hassan, A. S.; Fajardo, M. E.; Cummings, M.; McPherson, L. M.; Negro, F.; Dewald, J. P.; Heckman, C.; Pearcey, G. E.
10.1101/2021.06.18.448899 — physiology — Posted on 2021-06-18
1591 A human iPSC derived bone marrow milieu identifies a novel target against niche-conferred leukaemia proliferation and treatment resistance
Pal, D.; Blair, H.; Boyd, S.; Angel, S.; Nizami, S.; Isa, A.; Beckett, M.; Nelson, R.; Wilson, A.; Singh, M.; Sankar, S.; Tirtakusuma, R.; Nakjang, S.; Knill, C.; Fuller, A.; McNeill, H.; Russell, L.; Schwab, C.; Zhou, P.; Sinclair, P.; Coxhead, J.; Filby, A.; Allan, J.; Halsey, C.; Harrison, C.; Moorman, A.; Heidenreich, O.; Vormoor, J.
10.1101/2021.06.18.448490 — cancer biology — Posted on 2021-06-18
1593 Interactome analyses reveal profound proteasome structural and functional rearrangements throughout mammalian spermatogenesis
Zivkovic, D.; Sanchez Dafun, A.; Menneteau, T.; Schahl, A.; Lise, S.; Kervarrec, C.; Toste-Rego, A.; da Fonseca, P.; Chavent, M.; Pineau, C.; Schiltz, O.; Marcoux, J.; Bousquet, M.-P.
10.1101/2021.06.18.447862 — biochemistry — Posted on 2021-06-18
1595 A highly efficient reporter system for identifying and characterizing in vitro expanded hematopoietic stem cells
Che, J. L. C.; Bode, D.; Kucinski, I.; Cull, A. H.; Bain, F.; Barile, M.; Boyd, G.; Belmonte, M.; Jassinskaja, M.; Rubio-Lara, J.; Shepherd, M. S.; Clay, A.; Wilkinson, A. C.; Nakauchi, H.; Yamazaki, S.; Göttgens, B.; Kent, D. G.
10.1101/2021.06.18.448972 — cell biology — Posted on 2021-06-18
1596 A new approach to measure forces at junction vertices in an epithelium
Villeneuve, C.; Mathieu, S.; Lagoutte, E.; Goud, B.; Chavrier, P.; Manneville, J.-B.; Rosse, C.
10.1101/2021.06.18.448930 — cell biology — Posted on 2021-06-18
1598 Tfap2b specifies an embryonic melanocyte stem cell population that retains adult multi-fate potential
Brombin, A.; Simpson, D. J.; Travnickova, J.; Brunsdon, H. R.; Zeng, Z.; Lu, Y.; Chandra, T.; Patton, E. E.
10.1101/2021.06.18.448859 — developmental biology — Posted on 2021-06-18
1599 Endocytic vacuole formation by WASH-mediated endocytosis
Brinkert, P.; Krebs, L.; Samperio Ventayol, P.; Greune, L.; Bannach, C.; Bucher, D.; Kollasser, J.; Dersch, P.; Boulant, S.; Stradal, T. E. B.; Schelhaas, M.
10.1101/2021.06.18.448076 — cell biology — Posted on 2021-06-18
1600 Characterization of a flexible AAV-DTR/DT mouse model of acute epithelial lung injury
Griesser, E.; Schoenberger, T.; Stierstorfer, B.; Wyatt, H.; Rist, W.; Lamla, T.; Thomas, M. J.; Lamb, D.; Geillinger-Kaestle, K.
10.1101/2021.06.18.445859 — cell biology — Posted on 2021-06-18
1601 Progesterone receptor-A isoform interaction with RUNX transcription factors controls chromatin remodelling at promoters during ovulation
Dinh, T. D.; Breen, J.; Nicol, B.; Smith, K. M.; Nicholls, M.; Emery, A.; Wong, Y. Y.; Barry, S. C.; Yao, H. H.-C.; Robker, R. L.; Russell, D. L.
10.1101/2021.06.17.448908 — molecular biology — Posted on 2021-06-18
1602 Structural basis for PoxtA-mediated resistance to Phenicol and Oxazolidinone antibiotics
Crowe-McAuliffe, C.; Murina, V.; Kasari, M.; Takada, H.; Turnbull, K. J.; Polikanov, Y. S.; Sundsfjord, A.; Hegstad, K.; Atkinson, G. C.; Wilson, D. N.; Hauryliuk, V.
10.1101/2021.06.18.448924 — microbiology — Posted on 2021-06-18
1604 Analysis of human brain tissue derived from DBS surgery
Kangas, S. M.; Teppo, J.; Lahtinen, M. J.; Suoranta, A.; Ghimire, B. M.; Mattila, P.; Uusimaa, J.; Varjosalo, M.; Katisko, J.; Hinttala, R.
10.1101/2021.06.18.448926 — neuroscience — Posted on 2021-06-18
1607 Alpha peak frequency is linked to episodic memory impairment in pathological aging
Puttaert, D.; Wens, V.; Fery, P.; Rovai, A.; Trotta, N.; Coquelet, N.; De Breucker, S.; Sadeghi, N.; Coolen, T.; Goldman, S.; Peigneux, P.; Bier, J.-C.; De Tiege, X.
10.1101/2021.06.18.448931 — neuroscience — Posted on 2021-06-18
1608 External fertilization is orchestrated by a pH-regulated soluble adenylyl cyclase controlling sperm motility and chemotaxis
Koerschen, H. G.; Hamzeh, H.; Pascal, R.; Alvarez, L.; Boenigk, W.; Kaur, N.; Levin, L.; Buck, J.; Kambach, C.; Michino, M.; Jennings, A.; Sato, A.; Seifert, R.; Struenker, T.; Steegborn, C.; Kaupp, U. B.
10.1101/2021.06.18.448929 — biophysics — Posted on 2021-06-18
1613 Single-cell RNA sequencing-based characterization of resident lung mesenchymal stromal cells in bronchopulmonary dysplasia
Mizikova, I.; Lesage, F.; Cyr-Depauw, C.; Cook, D. P.; Hurskainen, M.; Hanninen, S.; Vadivel, A.; Bardin, P.; Zhong, S.; Carpen, O.; Vanderhyden, B. C.; Thebaud, B.
10.1101/2021.06.18.448928 — cell biology — Posted on 2021-06-18
1615 Structural basis for the context-specific action of classic peptidyl transferase inhibitors.
Syroegin, E. A.; Flemmich, L.; Klepacki, D. S.; Vazquez-Laslop, N. S.; Micura, R.; Polikanov, Y. S.
10.1101/2021.06.17.448903 — molecular biology — Posted on 2021-06-18
1620 Detection of a novel enterotropic Mycoplasma gallisepticum-like in European Starling (Sturnus vulgaris) around poultry farms in France
Le Gall-Ladeveze, C.; Nouvel, L.-X.; Souvestre, M.; Croville, G.; Hygonenq, M.-C.; Guerin, J.-L.; Le Loc'h, G.
10.1101/2021.06.18.448922 — microbiology — Posted on 2021-06-18
1623 Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain
Martins, D.; Giacomel, A.; Williams, S. C.; Turkheimer, F. E.; Dipasquale, O.; Veronese, M.; PET templates working group,
10.1101/2021.06.18.448872 — neuroscience — Posted on 2021-06-18
1625 Teaching Python for Data Science: Collaborative development of a modular & interactive curriculum
Duda, M.; Sovacool, K. L.; Farzaneh, N.; Nguyen, V. K.; Haynes, S. E.; Falk, H.; Furman, K. L.; Walker, L. A.; Diao, R.; Oneka, M.; Drotos, A. C.; Woloshin, A.; Dotson, G. A.; Kriebel, A.; Meng, L.; Thiede, S. N.; Lapp, Z.; Wolford, B. N.
10.1101/2021.06.17.448726 — scientific communication and education — Posted on 2021-06-18
1626 Neural cell injury pathology due to high-rate mechanical loading
Estrada, J. B.; Cramer, H. C.; Scimone, M. T.; Buyukozturk, S.; Franck, C.
10.1101/2021.05.12.443823 — biophysics — Posted on 2021-06-18
1627 X-DPI: A structure-aware multi-modal deep learning model for drug-protein interactions prediction
Wang, P.; Zheng, S.; Jiang, Y.; Li, C.; Liu, J.; Wen, C.; Patronov, A.; Qian, D.; Chen, H.; Yang, Y.
10.1101/2021.06.17.448780 — bioinformatics — Posted on 2021-06-18
1629 Electrodetection of small molecules by conformation-mediated signal enhancement
Murugappan, K.; Sundaramoorthy, U.; Damry, A. M.; Nisbet, D. R.; Jackson, C. J.; Tricoli, A.
10.1101/2021.06.17.448904 — biochemistry — Posted on 2021-06-18
1634 Migration without interbreeding: evolutionary history of a highly selfing Mediterranean grass inferred from whole genomes
Stritt, C.; Gimmi, E. L.; Wyler, M.; Bakali, A. H.; Skalska, A.; Hasterok, R.; Mur, L. A. J.; Pecchioni, N.; Roulin, A. C.
10.1101/2020.09.03.280842 — evolutionary biology — Posted on 2021-06-18
1636 The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei
Bakari-Soale, M.; Ikenge, N. J.; Scheibe, M.; Butter, F.; Jones, N. G.; Kramer, S.; Engstler, M.
10.1101/2021.06.11.448066 — microbiology — Posted on 2021-06-18
1637 Towards more accurate preclinical glioblastoma modelling: reverse translation of clinical standard of care in a glioblastoma mouse model.
Riva, M.; Bevers, S.; Wouters, R.; Thirion, G.; Vandenbrande, K.; Vankerckhoven, A.; Berckmans, Y.; Verbeeck, J.; De Keersmaecker, K.; Coosemans, A.
10.1101/2021.06.17.448792 — neuroscience — Posted on 2021-06-18
1639 Oligomeric α-Synuclein induces skin degeneration in a reconstructed human epidermis model
Oliveira, J. T.; De Vecchi, R.; Dakic, V.; Vitoria, G.; Pedrosa, C.; Mendes, M.; Aragao, L. G. H. S.; Cardim-Pires, T. R.; Furtado, D. R.; Foguel, D.; Breton, L.; Bouez, C.; Guimaraes, M. Z. P.; Rehen, S.
10.1101/2021.06.17.448863 — neuroscience — Posted on 2021-06-18
1641 A personalized network framework reveals predictive axis of anti-TNF response across diseases
Gerassy-Vainberg, S.; Starosvetsky, E.; Gaujoux, R.; Blatt, A.; Maimon, N.; Gorelik, Y.; Pressman, S.; Alpert, A.; Bar-Yoseph, H.; Dubovik, T.; Perets, B.; Katz, A.; Milman, N.; Chowers, Y.; Shen-Orr, S. S.
10.1101/2021.06.16.448558 — systems biology — Posted on 2021-06-18
1646 LongStitch: High-quality genome assembly correction and scaffolding using long reads
Coombe, L.; Li, J. X.; Lo, T.; Wong, J.; Nikolic, V.; Warren, R. L.; Birol, I.
10.1101/2021.06.17.448848 — bioinformatics — Posted on 2021-06-18
1650 A Markov chain model of cancer treatment
Bayer, P.; Brown, J. S.; Dubbeldam, J.; Broom, M.
10.1101/2021.06.16.448669 — cancer biology — Posted on 2021-06-18
1651 Calponin-Homology Domain mediated bending of membrane associated actin filaments
Palani, S.; Suchenko, A.; Ghosh, S.; Ivorra-Molla, E.; Clarke, S.; Balasubramanian, M. K.; Koester, D. V.
10.1101/2020.07.10.197616 — biophysics — Posted on 2021-06-18
1657 Autopolyploidization affects transcript patterns and gene targeting frequencies in Physcomitrella
Rempfer, C.; Wiedemann, G.; Schween, G.; Kerres, K. L.; Lucht, J. M.; Horres, R.; Decker, E. L.; Reski, R.
10.1101/2021.06.17.448837 — plant biology — Posted on 2021-06-18
1662 Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision
Watson, J. A.; Ndila, C. M.; Uyoga, S.; Macharia, A. W.; Nyutu, G.; Tsofa, B.; Mohammed, S.; Peshu, N.; Mturi, N.; Ngetsa, C.; Leopold, S.; Kingston, H.; George, E. C.; Maitland, K.; Rockett, K.; Day, N. P.; Dondorp, A.; Bejon, P.; Williams, T. N.; Holmes, C. C.; White, N. J.
10.1101/2021.04.16.440107 — genetics — Posted on 2021-06-17
1664 Heparan Sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE
Li, M.; Ong, C. Y.; Langouet-Astrie, C. J.; TAN, L.; Verma, A.; Yang, Y.; Zhang, X.; Shah, D.; Schmidt, E. P.; Xu, D.
10.1101/2021.06.17.448852 — cell biology — Posted on 2021-06-17
1668 Autopolyploidization affects transcript patterns and gene targeting frequencies in Physcomitrella
Rempfer, C.; Wiedemann, G.; Schween, G.; Lucht, J. M.; Horres, R.; Decker, E. L.; Reski, R.
10.1101/2021.06.17.448837 — plant biology — Posted on 2021-06-17
1669 Characterization of endogenous Rubus yellow net virus in raspberries
Ho, T.; Broome, J. C.; Buhler, J. P.; O'Donovan, W.; Tian, T.; Diaz-Lara, A.; Martin, R. R.; Tzanetakis, I. E.
10.1101/2021.06.17.448838 — plant biology — Posted on 2021-06-17
1671 Benchmarking UMI-based single cell RNA-sequencing preprocessing workflows
You, Y.; Tian, L.; Su, S.; Dong, X.; Jabbari, J. S.; Hickey, P. F.; Ritchie, M. E.
10.1101/2021.06.17.448895 — bioinformatics — Posted on 2021-06-17
1672 Whole Genome Sequence and CAZyme distribution of the cellulase hyper producing filamentous fungus Penicillium janthinellum NCIM 1366
Christopher, M. K.; Sreeja-Raju, A.; Kooloth-Valappil, P. K.; Abraham, A.; Gokhale, D. V.; Sukumaran, R. K.
10.1101/2021.06.17.448855 — genomics — Posted on 2021-06-17
1674 Dual Dysfunction of Kir2.1 Underlies Conduction and Excitation-Contraction Coupling Defects Promoting Arrhythmias in a Mouse Model of Andersen-Tawil Syndrome Type 1
Macias, A.; Gonzalez-Guerra, A.; Moreno-Manuel, A. I.; Cruz, F. M.; Garcia-Quintans, N.; Gutierrez, L. K.; Roche-Molina, M.; Bermudez-Jimenez, F. J.; Andres, V.; Vera-Pedrosa, M. L.; Martinez-Carrascoso, I.; Bernal, J. A.; Jalife, J.
10.1101/2021.06.17.448833 — cell biology — Posted on 2021-06-17
1675 Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules
Cipriani, P. G.; Bay, O.; Zinno, J. P.; Gutwein, M.; Gan, H. H.; Mayya, V.; Chung, G.; Chen, J.; Fahs, H.; Guan, Y.; Duchaine, T.; Selbach, M.; Piano, F.; Gunsalus, K.
10.1101/2021.06.17.448425 — cell biology — Posted on 2021-06-17
1677 SARS-CoV-2 spike P681R mutation enhances and accelerates viral fusion
Saito, A.; Nasser, H.; Uriu, K.; Kosugi, Y.; Irie, T.; Shirakawa, K.; Sadamasu, K.; Kimura, I.; Ito, J.; Wu, J.; Ozono, S.; Tokunaga, K.; Butlertanaka, E. P.; Tanaka, Y. L.; Shimizu, R.; Shimizu, K.; Fukuhara, T.; Kawabata, R.; Sakaguchi, T.; Yoshida, I.; Asakura, H.; Nagashima, M.; Yoshimura, K.; Kazuma, Y.; Nomura, R.; Horisawa, Y.; Takaori-Kondo, A.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Nakagawa, S.; Ikeda, T.; Sato, K.
10.1101/2021.06.17.448820 — microbiology — Posted on 2021-06-17
1678 Metagenome-based comparisons of decay rates and host-specificity of fecal microbial communities for improved microbial source tracking
Suttner, B.; Lindner, B. G.; Kim, M.; Conrad, R. E.; Rodriguez, L. M.; Orellana, L. H.; Johnston, E. R.; Hatt, J. K.; Zhu, K. J.; Brown, J.; Konstantinidis, K. T.
10.1101/2021.06.17.448865 — microbiology — Posted on 2021-06-17
1679 Multi-Parameter Quantitative Imaging of Tumor Microenvironments Reveals Perivascular Immune Niches Associated with Anti-Tumor Immunity
Stoltzfus, C. R.; Sivakumar, R.; Kunz, L.; Olin Pope, B. E.; Menietti, E.; Speziale, D.; Adelfio, R.; Bacac, M.; Colombetti, S.; Perro, M.; Gerner, M. Y.
10.1101/2021.06.17.448881 — immunology — Posted on 2021-06-17
1680 Memory B cells control SARS-CoV-2 variants upon mRNA vaccination of naive and COVID-19 recovered individuals.
Sokal, A.; Barba-Spaeth, G.; Fernandez, I.; Broketa, M.; Azzaoui, I.; de La Selle, A.; Vandenberghe, A.; Fourati, S.; Roeser, A.; Meola, A.; Bouvier-Alias, M.; Crickx, E.; Languille, L.; Michel, M.; Godeau, B.; Gallien, S.; Melica, G.; Nguyen, Y.; Zarrouk, V.; Canoui-Poitrine, F.; Noizat-Pirenne, F.; Megret, J.; Pawlotsky, J.-M.; Fillatreau, S.; Brunhs, P.; Rey, F. A.; Weill, J.-C.; Reynaud, C.-A.; Chappert, P.; Mahevas, M.
10.1101/2021.06.17.448459 — immunology — Posted on 2021-06-17
1681 The predicted bZIP transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans
Lazetic, V.; Wu, F.; Cohen, L. B.; Reddy, K. C.; Chang, Y.-T.; Gang, S. S.; Bhabha, G.; Troemel, E. R.
10.1101/2021.06.17.448850 — immunology — Posted on 2021-06-17
1682 Oligomeric α-Synuclein induces skin degeneration in a reconstructed human epidermis model
Oliveira, J. T.; de Vecchi, R.; Dakic, V.; Vitoria, G.; Pedrosa, C.; Mendes, M.; Aragao, L. G. H. S.; Cardim-Pires, T. R.; Furtado, D. R.; Foguel, D.; Breton, L.; Bouez, C.; Guimaraes, M. Z. P.; Rehen, S.
10.1101/2021.06.17.448863 — neuroscience — Posted on 2021-06-17
1686 Neural cell injury pathology due to high-rate mechanical loading
Estrada, J. B.; Cramer, H. C.; Scimone, M. T.; Buyukozturk, S.; Franck, C.
10.1101/2021.05.12.443823 — biophysics — Posted on 2021-06-17
1690 Grazer behavior can regulate large-scale patterning of community states
Karatayev, V. A.; Baskett, M. L.; Kushner, D. J.; Shears, N. T.; Caselle, J. E.; Boettiger, C.
10.1101/722215 — ecology — Posted on 2021-06-17
1694 Dopamine pathway characterization during the reproductive mode switch in the pea aphid
LE TRIONNAIRE, G.; HUDAVERDIAN, S.; RICHARD, G.; TANGUY, S.; GLEONNEC, F.; PRUNIER-LETERME, N.; GAUTHIER, J.-P.; TAGU, D.
10.1101/2020.03.10.984989 — developmental biology — Posted on 2021-06-17
1695 Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4+ T cells
Hoek, K.; Greer, M. J.; Mcclanahan, K. G.; Nazmi, A.; Piazuelo, M. B.; Singh, K.; Wilson, K. T.; Olivares-Villagomez, D.
10.1101/2020.12.04.412056 — immunology — Posted on 2021-06-17
1704 Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition
Saffi, G. T.; Tang, E.; Inpanathan, S.; Mamand, S.; Fountain, A.; Salmena, L.; Botelho, R. J.
10.1101/705491 — cell biology — Posted on 2021-06-17
1706 Human iPSC-derived cerebral organoids model features of Leigh Syndrome and reveal abnormal corticogenesis
Romero-Morales, A. I.; Robertson, G. L.; Rastogi, A.; Rasmussen, M. L.; Temuri, H.; Chakrabarty, R. P.; McElroy, G. S.; Hsu, L.; Almonacid, P. M.; Millis, B. A.; Chandel, N. S.; Cartailler, J.-P.; Gama, V.
10.1101/2020.04.21.054361 — cell biology — Posted on 2021-06-17
1713 Automated compound testing in zebrafish xenografts identifies combined MCL-1 and BCL-XL inhibition to be effective against Ewing sarcoma
Grissenberger, S.; Sturtzel, C.; Wenninger-Weinzierl, A.; Scheuringer, E.; Bierbaumer, L.; Pascoal, S.; Toetzl, M.; Tomazou, E.; Delattre, O.; Surdez, D.; Kovar, H.; Halbritter, F.; Distel, M.
10.1101/2021.06.17.448794 — cancer biology — Posted on 2021-06-17
1714 Nanopore callers for epigenetics from limited supervised data
Yao, B.; Hsu, C.; Goldner, G.; Michaeli, Y.; Ebenstein, Y.; Listgarten, J.
10.1101/2021.06.17.448800 — bioinformatics — Posted on 2021-06-17
1716 Enhancing the interoperability of glycan data flow between ChEBI, PubChem, and GlyGen.
Navelkar, R.; Owen, G.; Mutherkrishnan, V.; Thiessen, P.; Bolton, E.; Cheng, T.; Edwards, N.; Tiemeyer, M.; Campbell, M.; Martin, M.; Vora, J.; Kahsay, R.; Mazumder, R.
10.1101/2021.06.17.448729 — bioinformatics — Posted on 2021-06-17
1717 The chemical synthesis of knob domain antibody fragments
Macpherson, A.; Birtley, J. R.; Broadbridge, R. J.; Brady, K.; Tang, Y.; Joyce, C.; Saunders, K.; Bogle, G.; Horton, J.; Kelm, S.; Taylor, R. D.; Franklin, R. J.; Selby, M. D.; Laabei, M.; Wonfor, T.; Vadysirisack, D.; Shi, J.; van den Elsen, J. M. H.; Lawson, A. D. G.
10.1101/2021.06.16.448769 — biochemistry — Posted on 2021-06-17
1721 Zebrafish pigment cells develop directly from persistent highly multipotent progenitors.
Nikaido, M.; Subkhankulova, T.; Uroshlev, L. A.; Kasianov, A. J.; Camargo Sosa, K.; Bavister, G.; Yang, X.; Rodrigues, F. S. L. M.; Carney, T. J.; Schwetlick, H.; Dawes, J. H. P.; Rocco, A.; Makeev, V.; Kelsh, R. N.
10.1101/2021.06.17.448805 — developmental biology — Posted on 2021-06-17
1722 Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data
France, M.; Fu, L.; Rutt, L.; Yang, H.; Humphrys, M.; Narina, S.; Gajer, P.; Ma, B.; Forney, L. J.; Ravel, J.
10.1101/2021.06.17.448822 — microbiology — Posted on 2021-06-17
1727 Cellular and molecular signatures of in vivo GABAergic neurotransmission in the human brain
Lukow, P. B.; Martins, D.; Veronese, M.; Vernon, A. C.; McGuire, P.; Turkheimer, F. E.; Modinos, G.
10.1101/2021.06.17.448812 — neuroscience — Posted on 2021-06-17
1728 Spatial structure, phase, and the contrast of natural images
Rideaux, R.; West, R. K.; Bex, P. J.; Mattingley, J. B.; Harrison, W. J.
10.1101/2021.06.16.448761 — neuroscience — Posted on 2021-06-17
1731 CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer
Zhao, N.; Trepka, k.; Wang, Y.-h.; Chopra, S.; Hooshdaran, N.; Kim, H.; Yang, J.; Zhuo, J.; Lim, S.; Leung, K. K.; Egusa, E.; Zhang, L. K.; Foye, A.; Chou, J.; Feng, F. Y.; Small, E. J.; Evans, M. J.; Wells, J. A.; Aggarwal, R.
10.1101/2021.06.17.448569 — cancer biology — Posted on 2021-06-17
1732 Image quantification technique reveals novel lung cancer cytoskeletal phenotype with partial EMT signature
Basu, A.; Paul, M. K.; Alioscha-Perez, M.; Grosberg, A.; Sahli, H.; Dubinett, S. M.; Weiss, S.
10.1101/2021.06.17.448784 — biophysics — Posted on 2021-06-17
1736 ACES: Analysis of Conservation with Expansive Species
Padhi, E. M.; Mehinovic, E.; Sams, E. I.; Ng, J. K.; Turner, T. N.
10.1101/2021.06.16.448733 — bioinformatics — Posted on 2021-06-17
1738 A hierarchy in clusters of cephalopod mRNA editing sites
Moldovan, M. A.; Chervontseva, Z.; Nogina, D.; Gelfand, M.
10.1101/2021.06.16.448723 — bioinformatics — Posted on 2021-06-17
1741 SPEAR: a proteomics approach for simultaneous protein expression and redox analysis
Doron, S.; Lampl, N.; Savidor, A.; Katina, C.; Gabashvili, A.; Levin, Y.; Rosenwasser, S.
10.1101/2021.06.17.448798 — biochemistry — Posted on 2021-06-17
1743 Interpreting TMEM67 missense variants of uncertain significance (VUS) in an animal model
Lange, K. I.; Best, S.; Tsiropoulou, S.; Berry, I.; Johnson, C. A.; Blacque, O. E.
10.1101/2021.06.17.448799 — genetics — Posted on 2021-06-17
1750 Proteomic changes induced by harmine in human brain organoids reveal signaling pathways related to neuroprotection
Karmirian, K.; Goto-Silva, L.; Nascimento, J. M.; Costa, M. N.; Salerno, J. A.; Ornelas, I. M.; Vanderborght, B.; Martins-de-Souza, D.; Rehen, S.
10.1101/2021.06.16.448740 — cell biology — Posted on 2021-06-17
1752 Bacterial factors drive the differential targeting of Guanylate Binding Proteins to Francisella and Shigella
VALEVA, S. V.; Michal, F.; Degabriel, M.; Rohde, J. R.; Randow, F.; Ernst, R. K.; Lagrange, B.; Henry, T.
10.1101/2021.06.16.448779 — microbiology — Posted on 2021-06-17
1753 Non-serotype 2 isolates from healthy pigs are a potential zoonotic reservoir of Streptococcus suis genetic diversity and antimicrobial resistance
Kittiwan, N.; Calland, J. K.; Mourkas, E.; Hitchings, M. D.; Murray, S.; Tadee, P.; Tadee, P.; Duangsonk, K.; Sheppard, S. K.; Meric, G.; Patchanee, P.; Pascoe, B.
10.1101/2021.06.17.447897 — microbiology — Posted on 2021-06-17
1754 Unsupervised Models of Mouse Visual Cortex
Nayebi, A.; Kong, N. C. L.; Zhuang, C.; Gardner, J. L.; Norcia, A. M.; Yamins, D. L. K.
10.1101/2021.06.16.448730 — neuroscience — Posted on 2021-06-17
1756 Bioluminescent Genetically Encoded Glutamate Indicator for Molecular Imaging of Neuronal Activity
Petersen, E. D.; Crespo, E. C.; Lambert, G. G.; Zanca, A. T.; Orcutt, R.; Hochgeschwender, U.; Nathan, S. C.; Gilad, A.
10.1101/2021.06.16.448690 — neuroscience — Posted on 2021-06-17
1759 The Cost of Untracked Diversity in Brain-Imaging Prediction
Benkarim, O.; Paquola, C.; Park, B.-y.; Kebets, V.; Hong, S.-J.; Vos de Wael, R.; Zhang, S.; Yeo, B. T. T.; Eickenberg, M.; Ge, T.; Poline, J.-B.; Bernhardt, B.; Bzdok, D.
10.1101/2021.06.16.448764 — neuroscience — Posted on 2021-06-17
1760 Tau interactome mapping reveals dynamic processes in synapses and mitochondria associated with neurodegenerative disease
Tracy, T. E.; Madero-Perez, J.; Swaney, D.; Chang, T. S.; Moritz, M.; Konrad, C.; Ward, M. E.; Stevenson, E.; Huttenhain, R.; Kauwe, G.; Mercedes, M.; Sweetland-Martin, L.; Chen, X.; Mok, S.-A.; Telpoukhovskaia, M.; Min, S.-W.; Wang, C.; Dongmin Sohn, P.; Martin, J.; Zhou, Y.; Manfredi, G.; Coppola, G.; Krogan, N. J.; Geschwind, D.; Gan, L.
10.1101/2021.06.17.448349 — neuroscience — Posted on 2021-06-17
1761 Time-resolved multivariate pattern analysis of infant EEG data
Ashton, K.; Zinszer, B.; Cichy, R.; Nelson, C.; Aslin, R.; Bayet, L.
10.1101/2021.06.16.448720 — neuroscience — Posted on 2021-06-17
1762 Presynaptic Mitochondrial Volume and Density Scale with Presynaptic Power Demand
Justs, K. A.; Lu, Z.; Chouhan, A. K.; Borycz, J. A.; Lu, Z.; Meinertzhagen, I. A.; Macleod, G. T.
10.1101/2021.06.17.448756 — neuroscience — Posted on 2021-06-17
1764 Emergent Statistical Laws in Single-Cell Transcriptomic Data
Lazzardi, S.; Valle, F.; Mazzolini, A.; Scialdone, A.; Caselle, M.; Osella, M.
10.1101/2021.06.16.448706 — systems biology — Posted on 2021-06-17
1767 Casein kinase 1D encodes a novel drug target in Hedgehog-GLI driven cancers and tumor-initiating cells resistant to SMO inhibition
Peer, E.; Aichberger, S. K.; Vilotic, F.; Wolfgang, G.; Parigger, T.; Grund-Groeschke, S.; Elmer, D. P.; Rathje, F.; Ramspacher, A.; Zaja, M.; Michel, S.; Hamm, S.; Aberger, F.
10.1101/2021.06.17.448773 — cancer biology — Posted on 2021-06-17
1774 Interspecific interactions regulate plant reproductive allometry in cereal-legume intercropping systems
Gaudio, N.; Violle, C.; Gendre, X.; Fort, F.; Mahmoud, R.; Pelzer, E.; Mediene, S.; Hauggaard-Nielsen, H.; Bedoussac, L.; Bonnet, C.; Corre-Hellou, G.; Couëdel, A.; Hinsinger, P.; Steen Jensen, E.; Journet, E.-P.; Justes, E.; Kammoun, B.; Litrico, I.; Moutier, N.; Naudin, C.; Casadebaig, P.
10.1101/2021.06.17.448782 — ecology — Posted on 2021-06-17
1776 Western diet increases COVID-19 disease severity in the Syrian hamster
Port, J. R.; Adney, D. R.; Schwarz, B.; Schulz, J.; Sturdevant, D. E.; Smith, B. J.; Avanzato, V.; Holbrook, M. G.; Purushotham, J.; Stromberg, K. A.; Leighton, I.; Bosio, C.; Shaia, C.; Munster, V.
10.1101/2021.06.17.448814 — microbiology — Posted on 2021-06-17
1778 A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice
Mao, T.; Israelow, B.; Lucas, C.; Vogels, C. B. F.; Fedorova, O.; Breban, M. I.; Menasche, B. L.; Dong, H.; Linehan, M.; Yale SARS-CoV-2 Genome Surveillance Initiative, ; Wilen, C. B.; Landry, M. L.; Grubaugh, N. D.; Pyle, A. M.; Iwasaki, A.
10.1101/2021.06.16.448754 — immunology — Posted on 2021-06-17
1779 Increase of both bottom-up and top-down attentional processes in high dream recallers
Ruby, P.; Masson, R.; Chatard, B.; Hoyer, R. S.; Bottemane, L.; Vallat, R.; Bidet-Caulet, A.
10.1101/2021.06.16.448743 — neuroscience — Posted on 2021-06-17
1782 Functional Organization of the Maternal and Paternal Human 4D Nucleome
Lindsly, S. M.; Jia, W.; Chen, H.; Liu, S.; Ronquist, S.; Chen, C.; Wen, X.; Stansbury, C.; Dotson, G.; Ryan, C.; Rehemtulla, A.; Omenn, G. S.; Wicha, M.; Li, S. C.; Muir, L.; Rajapakse, I.
10.1101/2020.03.15.992164 — genomics — Posted on 2021-06-17
1783 Peripheral CB1 receptor blockade acts as a memory enhancer through an adrenergic-dependent mechanism
Martinez-Torres, S.; Bergada-Martinez, A.; Ortega, J.; Galera-Lopez, L.; Hervera Abad, A.; Ortega-Alvaro, A.; Remmers, F.; Munoz-Moreno, E.; Soria, G.; del Rio, J. A.; Lutz, B.; Ruiz-Ortega, J. A.; Meana, J. J.; Maldonado, R.; Ozaita, A.
10.1101/2021.06.16.448227 — neuroscience — Posted on 2021-06-17
1788 The Gossypium anomalum genome as a resource for cotton improvement and evolutionary analysis of hybrid incompatibility
Grover, C. E.; Yuan, D.; Arick, M. A.; Miller, E. R.; Hu, G.; Peterson, D. G.; Wendel, J. F.; Udall, J. A.
10.1101/2021.06.16.448676 — genomics — Posted on 2021-06-17
1791 Tuning the immunostimulation properties of cationic lipid nanocarriers for nucleic acid delivery
Dey, A. K.; Nougarede, A.; Clement, F.; Fournier, C.; Jouvin-Marche, E.; Escude, M.; Jary, D.; Navarro, F. P.; Marche, P. N.
10.1101/2021.06.16.448666 — immunology — Posted on 2021-06-17
1792 PET-BIDS, an extension to the brain imaging data structure for positron emission tomography
Norgaard, M.; Matheson, G. J.; Hansen, H. D.; Thomas, A. G.; Searle, G.; Rizzo, G.; Veronese, M.; Giacomel, A.; Yaqub, M.; Tonietto, M.; Funck, T.; Gillman, A.; Boniface, H.; Routier, A.; Dalenberg, J. R.; Betthauser, T.; Feingold, F.; Markiewicz, C. J.; Gorgolewski, K. J.; Blair, R. W.; Appelhoff, S.; Gau, R.; Salo, T.; Niso, G.; Pernet, C.; Phillips, C.; Oostenveld, R.; Carson, R. E.; Gallezot, J.-D.; Knudsen, G. M.; Innis, R. B.; Ganz, M.
10.1101/2021.06.16.448390 — neuroscience — Posted on 2021-06-17
1793 Decline in constitutive proliferative activity in the zebrafish retina with ageing
Hernandez-Nunez, I.; Quelle-Regaldie, A.; Sanchez, L.; Adrio, F.; Candal, E.; Barreiro-Iglesias, A.
10.1101/2021.06.16.448637 — neuroscience — Posted on 2021-06-17
1796 Reactive astrocytes prevent maladaptive plasticity after ischemic stroke
Aswendt, M.; Wilhelmsson, U.; Wieters, F.; Stokowska, A.; Schmitt, F. J.; Pallast, N.; de Pablo, Y.; Mohammed, L.; Hoehn, M.; Pekna, M.; Pekny, M.
10.1101/2021.06.16.448657 — neuroscience — Posted on 2021-06-17
1798 Modelling hCDKL5 heterologous expression in bacteria
Fondi, M.; Gonzi, S.; Dziurzynski, M.; Turano, P.; Ghini, V.; Calvanese, M.; Colarusso, A.; Lauro, C.; Parrilli, E.; Tutino, M. L.
10.1101/2021.06.17.448472 — systems biology — Posted on 2021-06-17
1799 Reduced light access promotes hypocotyl growth via autophagy-mediated recycling
Ince, Y.; Fiorucci, A.-S.; Trevisan, M.; Galvao, V. C.; Johanna, K.; Wigger, L.; Pradervand, S.; Fouillen, L.; Van Delft, P.; MONGRAND, S.; Gallart-Ayala, H.; Ivanisevic, J.; Fankhauser, C.
10.1101/2021.06.16.448628 — plant biology — Posted on 2021-06-17
1801 The Myogenesis Program Drives Clonal Selection and Drug Resistance in Rhabdomyosarcoma
Patel, A. G.; Chen, X.; Huang, X.; Clay, M. R.; Komarova, N.; Krasin, M. J.; Pappo, A.; Tillman, H.; Orr, B. A.; McEvoy, J.; Gordon, B.; Blankenship, K.; Reilly, C.; Zhou, X.; Norrie, J. L.; Karlstrom, A.; Yu, J.; Wodarz, D.; Stewart, E.; Dyer, M. A.
10.1101/2021.06.16.448386 — cancer biology — Posted on 2021-06-17
1805 Semi-supervised sequence modeling for improved behavioral segmentation
Whiteway, M. R.; Schaffer, E. S.; Wu, A.; Buchanan, E. K.; Onder, O. F.; Mishra, N.; Paninski, L.
10.1101/2021.06.16.448685 — animal behavior and cognition — Posted on 2021-06-17
1808 Amyloid-beta, p-tau, and reactive microglia load are correlates of MRI cortical atrophy in Alzheimer's disease
Frigerio, I.; Boon, B. D.; Lin, C.-P.; Galis-de Graaf, Y.; Bol, J. G.; Preziosa, P.; Twisk, J.; Barkhof, F.; Hoozemans, J. J.; Bouwman, F. H.; Rozemuller, A. J.; van de Berg, W. D.; Jonkman, L. E.
10.1101/2021.06.16.448650 — neuroscience — Posted on 2021-06-17
1812 Behavioral and nociceptor states of inflammatory painacross timescales in 2D and 3D
Bohic, M.; Pattison, L. A.; Jhumka, Z. A.; Rossi, H.; Thackray, J. K.; Ricci, M.; Foster, W.; Arnold, J.; Mossazghi, N.; Yttri, E. A.; Tischfield, M. A.; Smith, E. S. J.; Abdus-Saboor, I.; Abraira, V. E.
10.1101/2021.06.16.448689 — neuroscience — Posted on 2021-06-17
1818 Long-term quality assessment and monitoring of light microscope performance through accessible and reliable protocols, tools and metrics
Faklaris, O.; Bancel-Vallee, L.; Dauphin, A.; Monterroso, B.; Frere, P.; Geny, D.; Manoliu, T.; de Rossi, S.; Cordelieres, F. P.; Schapman, D.; Nitschke, R.; Cau, J.; Guilbert, T.
10.1101/2021.06.16.448633 — scientific communication and education — Posted on 2021-06-17
1821 Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins
Mesnage, R.; Bowyer, R. C. E.; El Balkhi, S.; Saint-Marcoux, F.; Gardere, A.; Ducarmon, Q. R.; Geelen, A. R.; Zwittink, R. D.; Tsoukalas, D.; Sarandi, E.; Paramera, E. I.; Spector, T.; Steves, C.; Antoniou, M.
10.1101/2021.06.16.448511 — pharmacology and toxicology — Posted on 2021-06-17
1823 EPAC1 Inhibition Protects the Heart from Doxorubicin-Induced Toxicity
Mazevet, M.; Ribeiro, M.; Belhadef, A.; Dayde, D.; Llach, A.; Laudette, M.; Belleville, T.; Mateo, P.; Gressette, M.; Lefebvre, F.; Chen, J.; Bachelot-Loza, C.; Rucker-Martin, C.; Lezoualch, F.; Crozatier, B.; Benitah, J.-P.; Vozenin, M.-C.; Fischmeister, R.; Gomez, A.-M.; Lemaire, C.; Morel, E.
10.1101/2021.06.16.448655 — pathology — Posted on 2021-06-17
1827 GBS-SBG - GBS Serotyping by Genome Sequencing
Tiruvayipati, S.; Tang, W. Y.; Barkham, T. M. S.; Chen, S. L.
10.1101/2021.06.16.448630 — bioinformatics — Posted on 2021-06-17
1832 SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta
Argueta, L. B.; Lacko, L. A.; Bram, Y.; Tada, T.; Carrau, L.; Zhang, T.; Uhl, S.; Lubor, B. C.; Chandar, V.; Gil, C.; Zhang, W.; Dodson, B.; Bastiaans, J.; Prabhu, M.; Salvatore, C. M.; Yang, Y. J.; Baergen, R. N.; tenOever, B. R.; Landau, N. R.; Chen, S.; Schwartz, R. E.; Stuhlmann, H.
10.1101/2021.06.01.446676 — cell biology — Posted on 2021-06-17
1833 Non-permissive SARS-CoV-2 infection in human neurospheres
Pedrosa, C. d. S. G.; Goto-Silva, L.; Temerozo, J. R.; Souza, L. R. Q.; Vitoria, G.; Ornelas, I. M.; Karmirian, K.; Mendes, M. A.; Gomes, I. C.; Sacramento, C. Q.; Fintelman-Rodrigues, N.; Soares, V. C.; Dias, S. d. S. G.; Salerno, J. A.; Puig-Pijuan, T.; Oliveira, J. T.; Aragao, L. G. H.; Torquato, T. C. Q.; Verissimo, C.; Biagi, D.; Cruvinel, E. M.; Dariolli, R.; Furtado, D. R.; Borges, H. L.; Bozza, P. T.; Rehen, S.; Souza, T. M. L.; Guimaraes, M. Z. P.
10.1101/2020.09.11.293951 — neuroscience — Posted on 2021-06-17
1838 Evidence for novel transient cell clusters in the neonatal mouse retina
de Montigny, J.; Krishnamoorthy, V.; Rozenblit, F.; Gollisch, T.; Sernagor, E.
10.1101/2019.12.27.888792 — neuroscience — Posted on 2021-06-17
1842 FiCoS: a fine- and coarse-grained GPU-powered deterministic simulator for biochemical networks
Tangherloni, A.; Nobile, M. S.; Cazzaniga, P.; Capitoli, G.; Spolaor, S.; Rundo, L.; Mauri, G.; Besozzi, D.
10.1101/2021.01.15.426855 — systems biology — Posted on 2021-06-17
1843 Induced ligno-suberin vascular coating and tyramine-derived hydroxycinnamic acid amides restrict Ralstonia solanacearum colonization in resistant tomato roots
Kashyap, A.; Capellades, M.; Zhang, W.; Srinivasan, S.; Laromaine, A.; Serra, O.; Figueras, M.; Rencoret, J.; Gutierrez, A.; Valls, M.; Coll, N. S.
10.1101/2021.06.15.448549 — plant biology — Posted on 2021-06-17
1846 Charting human subcortical maturation across the adult lifespan with in vivo 7 T MRI
Miletic, S.; Bazin, P.-L.; Isherwood, S. J. S.; Keuken, M.; Alkemade, A.; Forstmann, B.
10.1101/2021.04.07.438765 — neuroscience — Posted on 2021-06-17
1847 Neural event segmentation of continuous experience in human infants
Yates, T. S.; Skalaban, L. J.; Ellis, C. T.; Bracher, A. J.; Baldassano, C.; Turk-Browne, N. B.
10.1101/2021.06.16.448755 — neuroscience — Posted on 2021-06-16
1849 Electrical Potentials of Protoscoleces of the Cestode Echinococcus granulosus from Bovine Origin
Carabajal, M. P.; Duran, M. A.; Olivera, S.; Fernandez Salom, M. J.; Cantiello, H. F.
10.1101/2021.06.16.448647 — zoology — Posted on 2021-06-16
1850 Gene expression shapes the patterns of parallel evolution of herbicide resistance in the agricultural weed Monochoria vaginalis
Tanigaki, S.; Uchino, A.; Okawa, S.; Miura, C.; Hamamura, K.; Matsuo, M.; Yoshino, N.; Ueno, N.; Toyama, Y.; Fukumi, N.; Kijima, E.; Masuda, T.; Shimono, Y.; Tominaga, T.; Iwakami, S.
10.1101/2021.03.10.434542 — plant biology — Posted on 2021-06-16
1852 RosettaSurf - a surface-centric computational design approach
Scheck, A.; Rosset, S.; Defferrard, M.; Loukas, A.; Bonet, J.; Vandergheynst, P.; Correia, B. E.
10.1101/2021.06.16.448645 — bioinformatics — Posted on 2021-06-16
1855 HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160
Liu, W.; Chou, T.-F.; Garrett-Thomson, S. C.; Seo, G.-Y.; Fedorov, E.; Ramagopa, U. A.; Bonanno, J. B.; Kakugawa, K.; Cheroutre, H.; Kronenberg, M.; Almo, S. C.
10.1101/2021.06.16.448617 — immunology — Posted on 2021-06-16
1856 Medial prefrontal activity at encoding determines enhanced recognition of threatening faces after 1.5 years
Liu, X.; Zhou, X.; Zeng, Y.; Li, J.; Zhao, W.; Xu, L.; Zheng, X.; Fu, M.; Yao, S.; Cannistraci, C. V.; Kendrick, K. M.; Becker, B.
10.1101/2020.08.25.266353 — neuroscience — Posted on 2021-06-16
1861 Metabolite discovery through global annotation of untargeted metabolomics data
Chen, L.; Lu, W.; Wang, L.; Xing, X.; Chen, Z.; Teng, X.; Zeng, X.; Muscarella, A. D.; Shen, Y.; Cowan, A. J.; McReynolds, M. R.; Kennedy, B.; Lato, A. M.; Campagna, S. R.; Singh, M.; Rabinowitz, J. D.
10.1101/2021.01.06.425569 — bioinformatics — Posted on 2021-06-16
1863 Bioengineering a Miniaturized In Vitro 3D Myotube Contraction Monitoring Chip For Modelization of Muscular Dystrophies
Rose, N.; Sonam, S.; Nguyen, T.; Grenci, G.; Bigot, A.; Muchir, A.; Ladoux, B.; Le Grand, F.; Trichet, L.
10.1101/2021.06.15.448543 — bioengineering — Posted on 2021-06-16
1864 Novel Integrative Modeling of Molecules and Morphology across Evolutionary Timescales
Ogilvie, H. A.; Mendes, F. K.; Vaughan, T. G.; Matzke, N. J.; Stadler, T.; Welch, D.; Drummond, A. J.
10.1101/242875 — evolutionary biology — Posted on 2021-06-16
1869 A genetic shift in an escaped transmitted/founder virus guides combinatorial vaccine design against HIV-1
Jain, S.; Uritskiy, G.; Mahalingam, M.; Batra, H.; Chand, S.; Trinh, H.; Beck, C.; Shin, W.-H.; AlSalmi, W.; Kijak, G.; Eller, L. A.; Kim, J.; Kihara, D.; Tovanabutra, S.; Ferrari, G.; Robb, M.; Rao, M.; Rao, V. B.
10.1101/2021.06.16.448593 — microbiology — Posted on 2021-06-16
1872 A connectomic study of a petascale fragment of human cerebral cortex
Shapson-Coe, A.; Januszewski, M.; Berger, D. R.; Pope, A.; Wu, Y.; Blakely, T.; Schalek, R. L.; Li, P. H.; Wang, S.; Maitlin-Shepard, J.; Karlupia, N.; Dorkenwald, S.; Sjostedt, E.; Leavitt, L.; Lee, D.; Bailey, L.; Fitzmaurice, A.; Kar, R.; Field, B.; Wu, H.; Wagner-Carena, J.; Aley, D.; Lau, J.; Lin, Z.; Wei, D.; Pfister, H.; Peleg, A.; Jain, V.; Lichtman, J. W.
10.1101/2021.05.29.446289 — neuroscience — Posted on 2021-06-16
1875 Hippocampus-lateral septum circuitry mediates foraging-related spatial memory
Davis, E. A.; Liu, C. M.; Decarie-Spain, L.; Tierno Lauer, L.; Gianatiempo, I. H.; Suarez, A. N.; Cortella, A. M.; Hahn, J. D.; Kanoski, S. E.
10.1101/2020.06.16.155721 — neuroscience — Posted on 2021-06-16
1877 Minicells from Highly Genome Reduced Escherichia coli: Cytoplasmic and Surface Expression of Recombinant Proteins and Incorporation in the Minicells
Yu, H.; Khkhlatchev, A. V.; Chew, C.; Illendula, A.; Conaway, M. R.; Dryden, K.; Maeda, D. L. N. F.; Rajasekaran, V.; Kester, M.; Zeichner, S. L.
10.1101/2021.06.16.448719 — synthetic biology — Posted on 2021-06-16
1878 The Human Tumor Atlas Network (HTAN) Breast PreCancer Atlas: A multi-omic integrative analysis of ductal carcinoma in situ with clinical outcomes
Strand, S. H.; Rivero-Gutierrez, B.; Houlahan, K. E.; Seoane, J. A.; King, L.; Risom, T.; Simpson, L. A.; Vennam, S.; Khan, A.; Cisneros, L.; Hardman, T.; Harmon, B.; Couch, F.; Gallagher, K.; Kilgore, M.; Rocque, G. B.; DeMichele, A.; King, T.; McAuliffe, P.; Nangia, J.; Lee, J.; Tseng, J.; Storniolo, A. M.; Thompson, A.; Gupta, G.; Burns, R.; Veis, D. J.; DeSchryver, K.; Zhu, C.; Matusiak, M.; Wang, J.; Zhu, S. X.; Tappenden, J.; Ding, D. Y.; Zhang, D.; Luo, J.; Jiang, S.; Varma, S.; Anderson, L.; Straub, C.; Srivastava, S.; Curtis, C.; Tibshirani, R.; Angelo, R. M.; Hall, A.; Owzar, K.; Pol
10.1101/2021.06.16.448585 — cancer biology — Posted on 2021-06-16
1879 Tumor suppressor PLK2 may serve as a biomarker in triple-negative breast cancer for improved response to PLK1 therapeutics
Gao, Y.; Kabotyanski, E. B.; Villegas, E.; Shepherd, J. H.; Acosta, D.; Hamor, C.; Sun, T.; Montemayor-Garcia, C.; He, X.; Dobrolecki, L. E.; Westbrook, T. F.; Lewis, M. T.; Hilsenbeck, S. G.; Zhang, X. H.- F.; Perou, C. M.; Rosen, J. M.
10.1101/2021.06.16.448722 — cancer biology — Posted on 2021-06-16
1880 Philympics 2021: Prophage Predictions Perplex Programs
Roach, M. J.; McNair, K.; Giles, S. K.; Inglis, L. K.; Pargin, E.; Roux, S.; Decewicz, P.; Edwards, R. A.
10.1101/2021.06.03.446868 — bioinformatics — Posted on 2021-06-16
1885 Blm Helicase Facilitates Rapid Replication of Repetitive DNA Sequences in early Drosophila Development
Ruchert, J. M.; Brady, M. M.; McMahan, S.; Lacey, K. J.; Latta, L. C.; Sekelsky, J.; Stoffregen, E. P.
10.1101/2021.06.16.448677 — genetics — Posted on 2021-06-16
1888 Age-related decline of the unfolded protein response in the heart promotes protein misfolding and cardiac pathology
Hofmann, C.; Blackwood, E. A.; Jakobi, T.; Sandmann, C.; Gross, J.; Herzog, N.; Kaufman, R. J.; Katus, H. A.; Völkers, M.; Glembotski, C. C.; Doroudgar, S.
10.1101/2021.06.16.448596 — molecular biology — Posted on 2021-06-16
1890 Crystal structure of the human NKR-P1 bound to its lymphocyte ligand LLT1 reveals receptor clustering in the immune synapse
Blaha, J.; Skalova, T.; Kalouskova, B.; Skorepa, O.; Cmunt, D.; Pazicky, S.; Polachova, E.; Abreu, C.; Stransky, J.; Koval, T.; Duskova, J.; Zhao, Y.; Harlos, K.; Hasek, J.; Dohnalek, J.; Vanek, O.
10.1101/2021.06.16.448687 — molecular biology — Posted on 2021-06-16
1895 NSun2 deficiency promotes tau hyperphosphorylation and neurodegeneration through epitranscriptomic regulation of miR-125b
Kim, Y. A.; Blaze, J.; Winters, T.; Kumar, A.; Tein, E.; Sproul, A. A.; Teich, A.; Bartolini, F.; Akbarian, S.; Hargus, G.; Santa-Maria, I.
10.1101/2021.06.16.448614 — neuroscience — Posted on 2021-06-16
1896 A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states
Draeger, N. M.; Sattler, S. M.; Huang, C. T.-L.; Teter, O. M.; Leng, K.; Hashemi, S. H.; Hong, J.; Clelland, C. D.; Zhan, L.; Kodama, L.; Singleton, A. B.; Nalls, M. A.; Ichida, J.; Ward, M. E.; Faghri, F.; Gan, L.; Kampmann, M.
10.1101/2021.06.16.448639 — neuroscience — Posted on 2021-06-16
1897 Cheater suppression and spite through quorum sensing
Moffett, A. S.; Thomas, P. J.; Hinczewski, M.; Eckford, A. W.
10.1101/2021.06.16.448736 — biophysics — Posted on 2021-06-16
1900 ultraID: a compact and efficient enzyme for proximity-dependent biotinylation in living cells
Zhao, X.; Bitsch, S.; Kubitz, L.; Schmitt, K.; Deweid, L.; Roehrig, A.; Cappio Barazzone, E.; Valerius, O.; Kolmar, H.; Bethune, J.
10.1101/2021.06.16.448656 — biochemistry — Posted on 2021-06-16
1902 Nafamostat-interferon-alpha combination suppresses SARS-CoV-2 infection in vitro and in vivo
Ianevski, A.; Yo, R.; Lysvand, H.; Grodeland, G.; Legrand, N.; Tenson, T.; Bjoras, M.; Kainov, D. E.
10.1101/2021.06.16.448653 — microbiology — Posted on 2021-06-16
1904 A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters
Wuertz, K. M.; Barkei, E.; Chen, W.-h.; Martinez, E. J.; Naouar, I. E.; Jagodzinski, L.; Paquin-Proulx, D.; Gromowski, G. D.; Swafford, I.; Ganesh, A.; Dong, M.; Zeng, X.; Thomas, P. V.; Sankhala, R. S.; Hajduczki, A.; Peterson, C. E.; Kuklis, C. H.; Soman, S.; Wieczorek, L.; Zemil, M.; Anderson, A.; Darden, J.; Hernandez, H.; Grove, H.; Dussupt, V.; Hack, H.; de la Barrera, R. A.; Zarling, S. N.; Wood, J. F.; Froude, J. W.; Gagne, M. J.; Henry, A. R.; Mokhtari, E. B.; Mudvari, P.; Krebs, S. J.; Pekosz, A. S.; Currier, J. R.; Kar, S.; Porto, M.; Winn, A.; Radzyminski, K.; Lewis, M. G.; Vasan,
10.1101/2021.06.16.448525 — immunology — Posted on 2021-06-16
1905 Center-surround interactions underlie bipolar cell motion sensing in the mouse retina
Strauss, S.; Korympidou, M. M.; Ran, Y.; Franke, K.; Schubert, T.; Baden, T.; Berens, P.; Euler, T.; Vlasits, A. L.
10.1101/2021.05.31.446404 — neuroscience — Posted on 2021-06-16
1907 Human motor cortical gamma activity relates to GABAergic signalling and to behaviour
Zich, C.; Nowak, M.; Hinson, E. L.; Quinn, A. J.; Woolrich, M. W.; Stagg, C. J.
10.1101/2021.06.16.448658 — neuroscience — Posted on 2021-06-16
1908 The Association Between Poor Sleep and Accelerated Brain Ageing
Ramduny, J.; Bastiani, M.; Huedepohl, R.; Sotiropoulos, S. S. N.; Chechlacz, M.
10.1101/2021.06.16.448332 — neuroscience — Posted on 2021-06-16
1909 SARS-CoV-2 envelope-protein corruption of homeostatic signaling mechanisms in mammalian cells
Schulze, T.; Hartel, A.; Hoeler, S.; Hemming, C.; Lehn, R.; Tandl, D.; Greiner, T.; Bertl, A.; Shepard, K.; Moroni, A.; Thiel, G.; Rauh, O.
10.1101/2021.06.16.448640 — pathology — Posted on 2021-06-16
1910 Pervasive fold switching in a ubiquitous protein superfamily
Porter, L.; Kim, A. K.; Looger, L. L.; Majumdar, A.; Starich, M. R.
10.1101/2021.06.10.447921 — bioinformatics — Posted on 2021-06-16
1911 SARS-CoV-2 Viral Replication in a High Throughput Human Primary Epithelial Airway Organ Model
Fisher, C. R.; Medie, F. M.; Luu, R. J.; Gaibler, R.; Miller, C. R.; Mulhern, T. J.; Vijayakumar, V.; Marr, E.; Alladina, J.; Medoff, B.; Borenstein, J. T.; Gard, A. L.
10.1101/2021.06.15.448611 — bioengineering — Posted on 2021-06-16
1913 A candidate for the sex-determination gene in tunas (Thunnus fishes)
Nakamura, Y.; Higuchi, K.; Kumon, K.; Yasuike, M.; Takashi, T.; Gen, K.; Fujiwara, A.
10.1101/2021.06.15.448492 — genomics — Posted on 2021-06-16
1917 Rapid genome editing by CRISPR-Cas9-POLD3 fusion
Reint, G.; Li, Z.; Labun, K.; Keskitalo, S.; Soppa, I.; Mamia, K.; Tolo, E.; Szymanska, M.; Meza-Zepeda, L. A.; Lorenz, S.; Cieslar-Pobuda, A.; Hu, X.; Bordin, D. L.; Staerk, J.; Valen, E.; Schmierer, B.; Varjosalo, M.; Taipale, J.; Haapaniemi, E.
10.1101/2021.05.23.445089 — molecular biology — Posted on 2021-06-16
1918 Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility
Charlesworth, A. G.; Seroussi, U.; Lehrbach, N. J.; Renaud, M. S.; Sundby, A. E.; Molnar, R. I.; Lao, R. X.; Willis, A. R.; Woock, J. R.; Aber, M. J.; Diao, A. J.; Reinke, A. W.; Ruvkun, G.; Claycomb, J. M.
10.1101/2020.07.20.212050 — molecular biology — Posted on 2021-06-16
1920 Lactate is a major energy substrate for cortical neurons and enhances their firing activity.
Karagiannis, A.; Gallopin, T.; Lacroix, A.; Plaisier, F.; Piquet, J.; Geoffroy, H.; Hepp, R.; Naude, J.; Le Gac, B.; Egger, R.; Lambolez, B.; Li, D.; Rossier, J.; Staiger, J. F.; Imamura, H.; Seino, S.; Roeper, J.; Cauli, B.
10.1101/2021.05.17.444414 — neuroscience — Posted on 2021-06-16
1924 Deciphering Tumour Tissue Organization by 3D Electron Microscopy and machine learning
Denis de Senneville, B.; Khoubai, F. Z.; Bevilacqua, M.; Labedade, A.; Flosseau, K.; Chardot, C.; Branchereau, S.; Ripoche, J.; Cairo, S.; Gontier, E.; Grosset, C.
10.1101/2021.06.15.446847 — cancer biology — Posted on 2021-06-16
1925 Colorectal cancer progression is potently reduced by a glucose-free, high-protein diet: comparison to anti-EGFR therapy
Skibbe, K.; Brethack, A.-K.; Suenderhauf, A.; Ragab, M.; Raschdorf, A.; Hicken, M.; Schlichting, H.; Preira, J.; Brandt, J.; Castven, D.; Foeh, B.; Pagel, R.; Marquardt, J. U.; Sina, C.; Derer, S.
10.1101/2021.06.15.448354 — cancer biology — Posted on 2021-06-16
1928 Convergence of case-specific epigenetic alterations identify a confluence of genetic vulnerabilities tied to opioid dependence
Corradin, O.; Sallari, R.; Hoang, A. T.; Kassim, B. S.; Ben Hutta, G.; Cuoto, L.; Quach, B. C.; Lovrenert, K.; Hays, C.; Gryder, B. E.; Iskhakova, M.; Cates, H.; Song, Y.; Bartels, C. F.; Hancock, D. B.; Mash, D. C.; Johnson, E. O.; Akbarian, S.; Scacheri, P. C.
10.1101/2021.06.15.447736 — genomics — Posted on 2021-06-16
1934 Systematic dissection of a complex gut bacterial community
Cheng, A. G.; Aranda-Diaz, A.; Jain, S.; Yu, F.; Iakiviak, M.; Meng, X.; Weakley, A.; Patil, A.; Shiver, A. L.; Deutschbauer, A.; Neff, N.; Huang, K.; Fischbach, M. A.
10.1101/2021.06.15.448618 — microbiology — Posted on 2021-06-16
1935 In vivo augmentation of a complex gut bacterial community
Cheng, A. G.; Ho, P.-Y.; Jain, S.; Meng, X.; Wang, M.; Yu, B.; Iakiviak, M.; Brumbaugh, A. R.; Nagashima, K.; Zhao, A.; Patil, A.; Atabakhsh, K.; Weakley, A.; Yan, J.; Higginbottom, S.; Neff, N.; Sonnenburg, J. L.; Huang, K.; Fischbach, M. A.
10.1101/2021.06.15.448620 — microbiology — Posted on 2021-06-16
1936 Dietary palmitic acid induces trained immunity that controls inflammation and infection
Seufert, A. L.; Hickman, J. W.; Traxler, S. K.; Peterson, R. M.; Lashley, S. J.; Shulzhenko, N.; Napier, R. J.; Napier, B. A.
10.1101/2021.06.15.448579 — immunology — Posted on 2021-06-16
1937 The anatomical logic of smell
Ruiz Tejada Segura, M. L.; Abou Moussa, E.; Garabello, E.; Nakahara, T. S.; Makhlouf, M.; Mathew, L. S.; Valle, F.; Huang, S. S. Y.; Mainland, J. D.; Caselle, M.; Osella, M.; Lorenz, S.; Reisert, J.; Logan, D. W.; Malnic, B.; Scialdone, A.; Saraiva, L. R.
10.1101/2021.06.16.448475 — neuroscience — Posted on 2021-06-16
1939 Freely-moving mice visually pursue prey using a retinal area with least optic flow
Holmgren, C. D.; Stahr, P.; Wallace, D. J.; Voit, K.-M.; Matheson, E. J.; Sawinski, J.; Bassetto, G.; Kerr, J. N. D.
10.1101/2021.06.15.448520 — neuroscience — Posted on 2021-06-16
1941 Emergent properties of coupled bistable switches
Hari, K.; Harlapur, P.; Gopalan, A.; Ullanat, V.; Duddu, A. S.; Jolly, M. K.
10.1101/2021.06.15.448553 — systems biology — Posted on 2021-06-16
1942 Developing and deploying an integrated workshop curriculum teaching computational skills for reproducible research
Lapp, Z.; Sovacool, K. L.; Lesniak, N. A.; King, D.; Barnier, C.; Flickinger, M.; Krüger, J.; Armour, C. R.; Lapp, M. M.; Tallant, J.; Diao, R.; Oneka, M.; Tomkovich, S.; Anderson, J. M.; Lucas, S. K.; Schloss, P. D.
10.1101/2021.06.15.448091 — scientific communication and education — Posted on 2021-06-16
1944 Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload
Guo, A. H.; Baliira, R. K.; Skinner, M. E.; Kumar, S.; Andren, A.; Zhang, L.; Michan, S.; Davis, N. J.; Maccani, M. W.; Day, S.; Sinclair, D. A.; Lyssiotis, C. A.; Stein, A. B.; Lombard, D. B.
10.1101/2021.06.15.448619 — pathology — Posted on 2021-06-16
1949 Raman Needle Arthroscopy for In Vivo Molecular Assessment of Cartilage
Kroupa, K.; Wu, M. I.; Zhang, J.; Jensen, M.; Wong, W.; Engiles, J. B.; Grinstaff, M. W.; Snyder, B. D.; Bergholt, M. S.; Albro, M. B.
10.1101/2021.06.15.448529 — bioengineering — Posted on 2021-06-16
1950 Beta-Catenin Limits Osteogenesis on Regenerative Materials in a Stiffness-Dependent Manner
Zhou, Q.; Ren, X.; Oberoi, M. K.; Caprini, R. M.; Dewey, M. J.; Kolliopoulos, V.; Yamaguchi, D. T.; Harley, B. A. C.; Lee, J. C.
10.1101/2021.06.15.447161 — bioengineering — Posted on 2021-06-16
1953 Sticking around: plant persistence strategies on edaphic islands
Ottaviani, G.; Mendez Castro, F. E.; Conti, L.; Zeleny, D.; Chytry, M.; Dolezal, J.; Jandova, V.; Altman, J.; Klimesova, J.
10.1101/2021.06.15.448516 — ecology — Posted on 2021-06-16
1954 Incorporating evolutionary and threat processes into crop wild relatives conservation
Tobon-Niedfeldt, W.; Mastretta-Yanes, A.; Urquiza-Haas, T.; Goettsch, B.; Cuervo-Robayo, A.; Urquiza-Haas, E.; Orjuela-R, M. A.; Acevedo Gasman, F.; Oliveros-Galindo, O.; Burgeff, C.; Rivera-Rodriguez, D.; Sanchez Gonzalez, J. d. J.; Alarcon-Guerrero, J.; Sarukhan, J.; Koleff, P.
10.1101/2021.06.15.448560 — ecology — Posted on 2021-06-16
1957 Diel population dynamics and mortality of Prochlorococcus in the North Pacific Subtropical Gyre
Beckett, S. J.; Demory, D.; Coenen, A. R.; Casey, J. R.; Dugenne, M.; Follett, C. L.; Connell, P.; Carlson, M. C. G.; Hu, S. K.; Wilson, S. T.; Muratore, D.; Rodriguez-Gonzalez, R. A.; Peng, S.; Becker, K. W.; Mende, D. R.; Armbrust, E. V.; Caron, D. A.; Lindell, D.; Follows, M. J.; White, A. E.; Ribalet, F.; Weitz, J. S.
10.1101/2021.06.15.448546 — ecology — Posted on 2021-06-16
1960 Multiple RSV strains infecting HEp-2 and A549 cells reveal cell line-dependent differences in resistance to RSV infection.
Rajan, A.; Piedra, F.-A.; Aideyan, L.; McBride, T.; Robertson, M. J.; Johnson, H. L.; Aloisio, G. M.; Henke, D. M.; Coarfa, C.; Stossi, F.; Menon, V. K.; Doddapaneni, H.; Muzny, D.; Javornik Cregeen, S. J.; Hoffman, K. L.; Petrosino, J. F.; Gibbs, R.; Avadhanula, V.; Piedra, P. A.
10.1101/2021.06.15.448622 — microbiology — Posted on 2021-06-16
1962 Macrophages stimulate epicardial VEGFaa to trigger cardiomyocyte proliferation in larval zebrafish heart regeneration
Bruton, F. A.; Kaveh, A.; Ross-Stewart, K.; Matrone, G.; Oremek, M. E.; Solomonidis, E. G.; Tucker, C. S.; Mullins, J. J.; Brittan, M.; Taylor, J. M.; Rossi, A. G.; Denvir, M. A.
10.1101/2021.06.15.448575 — immunology — Posted on 2021-06-16
1963 Attrition Rate in Infant fNIRS Research: A Meta-Analysis
Baek, S.; Marques, S.; Casey, K.; Testerman, M.; McGill, F.; Emberson, L.
10.1101/2021.06.15.448526 — neuroscience — Posted on 2021-06-16
1964 Restoring statistical validity in group analyses of motion-corrupted MRI data
Lutti, A.; Corbin, N.; Ashburner, J.; Ziegler, G.; Draganski, B.; Phillips, C.; Kherif, F.; Callaghan, M. F.; Di Domenicantonio, G.
10.1101/2021.06.15.448467 — neuroscience — Posted on 2021-06-16
1966 Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain
Dedek, A.; Xu, J.; Lorenzo, L.-E.; Godin, A. G.; Kandegedara, C. M.; Glavina, G.; Landrigan, J. A.; Lombroso, P. J.; De Koninck, Y.; Tsai, E. C.; Hildebrand, M. E.
10.1101/2021.06.15.447407 — neuroscience — Posted on 2021-06-16
1972 NEST Desktop - An educational application for neuroscience
Spreizer, S.; Senk, J.; Rotter, S.; Diesmann, M.; Weyers, B.
10.1101/2021.06.15.444791 — neuroscience — Posted on 2021-06-16
1973 Linking carbohydrate structure with function in the human gut microbiome using hybrid metagenome assemblies
Ravi, A.; Troncoso-Rey, P.; Ahn-Jarvis, J.; Corbin, K. R.; Harris, S.; Harris, H.; Aydin, A.; Kay, G. L.; Le-Viet, T.; Gilroy, R.; PALLEN, M. J.; Page, A. J.; O'Grady, J.; Warren, F.
10.1101/2021.05.11.441322 — microbiology — Posted on 2021-06-16
1974 Implicating Gene and Cell Networks Responsible for Differential COVID-19 Host Responses via an Interactive Single Cell Web Portal
Jin, K.; Bardes, E. E.; Mitelpunkt, A.; Wang, Y. J.; Bhatnagar, S.; Sengupta, S.; Krummel, D. P.; Rothenberg, M. E.; Aronow, B. J.
10.1101/2021.06.07.447287 — immunology — Posted on 2021-06-16
1975 Honey bees cannot sense harmful concentrations of metal pollutants in food
MONCHANIN, C.; DE BRITO SANCHEZ, G.; LECOUVREUR, L.; BOIDARD, O.; MERY, G.; SILVESTRE, J.; LE ROUX, G.; BAQUE, D.; ELGER, A.; BARRON, A.; LIHOREAU, M.; DEVAUD, J.-M.
10.1101/2021.06.15.448345 — neuroscience — Posted on 2021-06-16
1976 3D reconstruction identifies loci linked to variation in angle of individual sorghum leaves
Tross, M. C.; Gaillard, M.; Zwiener, M.; Miao, C.; Li, B.; Benes, B.; Schnable, J. C.
10.1101/2021.06.15.448566 — plant biology — Posted on 2021-06-16
1978 Universal and Programmable Thinning and Thickening of Topologically-Active DNA Fluids
Michieletto, D.; Neill, P.; Weir, S.; Martinez, V. A.; Evans, D.; Crist, N.; Anderson, R.
10.1101/2021.06.16.448664 — biophysics — Posted on 2021-06-16
1981 Inhibitory and Stimulatory Micropeptides Preferentially Bind to Different Conformations of the Cardiac Calcium Pump
Cleary, S. R.; Fang, X.; Cho, E. E.; Pribadi, M. P.; Seflova, J.; Beach, J. R.; Kekenes-Huskey, P.; Robia, S. L.
10.1101/2021.06.15.448555 — biophysics — Posted on 2021-06-16
1982 Mineral crystal thickness in calcified cartilage and subchondral bone in healthy and osteoarthritic knees
Finnilä, M. A. J.; Das Gupta, S.; Turunen, M. J.; Kestilä, I.; Turkiewicz, A.; Lutz-Bueno, V.; Folkesson, E.; Holler, M.; Ali, N.; Hughes, V.; Isaksson, H.; Tjörnstrand, J.; Önnerfjord, P.; Guizar-Sicairos, M.; Saarakkala, S.; Englund, M.
10.1101/2021.06.15.448181 — biophysics — Posted on 2021-06-16
1984 In depth analysis of Cyprus-specific mutations of SARS-CoV-2 strains using computational approaches
Oulas, A.; Richter, J.; Zanti, M.; Tomazou, M.; Michailidou, K.; Christodoulou, K.; Christodoulou, C.; Spyrou, G. M.
10.1101/2021.06.08.447477 — bioinformatics — Posted on 2021-06-16
1985 The respiratory supercomplex from C. glutamicum
Moe, A.; Kovalova, T.; Krol, S.; Yanofsky, D. J.; Bott, M.; Sjöstrand, D.; Rubinstein, J. L.; Högbom, M.; Brzezinski, P.
10.1101/2021.06.16.448340 — biochemistry — Posted on 2021-06-16
1988 CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels
Gonçalves, A. B.; Hasselbalch, S. K.; Joensen, B. B.; Patzke, S.; Martens, P.; Ohlsen, S. K.; Quinodoz, M.; Nikopoulus, K.; Suleiman, R.; Jeppesen, M. P. D.; Weiss, C.; Christensen, S. T.; Rivolta, C.; Andersen, J. S.; Farinelli, P.; Pedersen, L. B.
10.1101/2020.10.05.325936 — cell biology — Posted on 2021-06-16
1990 Structure of mycobacterial cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates
Zhou, S.; Wang, W.; Zhou, X.; Zhang, Y.; Lai, Y.; Tang, Y.; Xu, J.; Yang, X.; Guddat, L. W.; Wang, Q.; Gao, Y.; Rao, Z.; Gong, H.
10.1101/2021.06.15.448498 — microbiology — Posted on 2021-06-16
1991 A molecular census of midbrain dopaminergic neurons in Parkinson's disease
Kamath, T.; Abdulraouf, A.; Burris, S.; Gazestani, V.; Nadaf, N.; Vanderburg, C.; Macosko, E.
10.1101/2021.06.16.448661 — neuroscience — Posted on 2021-06-16
1995 Rapid homeostatic modulation of transsynaptic nanocolumn rings
Muttathukunnel, P.; Frei, P.; Perry, S.; Dickman, D.; Mueller, M.
10.1101/2021.06.15.448550 — neuroscience — Posted on 2021-06-16
2001 Conservation of endangered galaxiid fishes in the Falkland Islands requires urgent action on invasive brown trout
Minett, J. F.; Fowler, D. M.; Jones, J.; Brickle, P.; Crossin, G. T.; Consuegra, S.; Garcia de Leaniz, C.
10.1101/2021.06.15.448501 — ecology — Posted on 2021-06-16
2002 Does an artistic representation of brand logos increase their effect on customers?
Kraemer, J.; Rott, T.; Tenberge, J.-G.; Schiffler, P.; Johnen, A.; Landmeyer, N. C.; Olivier, F.; Wiendl, H.; Meuth, S. G.
10.1101/2021.06.15.448420 — neuroscience — Posted on 2021-06-16
2003 Whole-brain studies of spontaneous behavior in head-fixed rats enabled by zero echo time MB-SWIFT fMRI
Paasonen, J.; Stenroos, P.; Laakso, H.; Pirttimaki, T.; Paasonen, E.; Salo, R. A.; Tanila, H.; Idiyatullin, D.; Garwood, M.; Michaeli, S.; Mangia, S.; Grohn, O.
10.1101/2021.06.15.448321 — neuroscience — Posted on 2021-06-16
2004 DOPAL initiates αSynuclein-mediated impaired proteostasis in neuronal projections leading to enhanced vulnerability in Parkinson's disease.
Masato, A.; Plotegher, N.; Thor, A.; Adams, S.; Sandre, M.; Cogo, S.; De Lazzari, F.; Fontana, C. M.; Martinez, P. A.; Strong, R.; Bellucci, A.; Bisaglia, M.; Greggio, E.; Dalla Valle, L.; Boassa, D.; Bubacco, L.
10.1101/2021.06.15.448476 — neuroscience — Posted on 2021-06-16
2005 HKG: An open genetic variant database of 205 Hong Kong Cantonese exomes
Ou, M.; Leung, H. C.-M.; Leung, A. W.-S.; Luk, H.-M.; Yan, B.; Liu, C.-M.; Tong, T. M.-F.; Mok, M. T.-S.; Ko, W. M.-Y.; Law, W.-C.; Lam, T.-W.; Lo, I. F.-M.; Luo, R.
10.1101/2021.06.15.448515 — bioinformatics — Posted on 2021-06-16
2008 15 years of introgression studies: quantifying gene flow across Eukaryotes
Dagilis, A. J.; Peede, D.; Coughlan, J. M.; Jofre, G. I.; D'Agostino, E. R. R.; Mavengere, H.; Tate, A. D.; Matute, D. R.
10.1101/2021.06.15.448399 — evolutionary biology — Posted on 2021-06-16
2010 Repression of Hypoxia-Inducible Factor-1 Contributes to Increased Mitochondrial Reactive Oxygen Species Production in Diabetes
Zheng, X.; Narayanan, S.; Xu, C.; Eliasson Angelstig, S.; Grünler, J.; Zhao, A.; Di Toro, A.; Bernardi, L.; Mazzone, M.; Carmeliet, P.; Del Sole, M.; Solaini, G.; Forsberg, E. A.; Zhang, A.; Brismar, K.; Schiffer, T. A.; Rajamand Ekberg, N.; Botusan, I. R.; Palm, F.; Catrina, S.-B.
10.1101/2021.06.15.448500 — cell biology — Posted on 2021-06-16
2011 High efficacy of therapeutic equine hyperimmune antibodies against SARS CoV-2 variants of concern
Moreira-Soto, A.; Arguedas, M.; Brenes, H.; Bujan, W.; Corrales-Aguilar, E.; Diaz, C.; Echeverri, A.; Flores-Diaz, M.; Gomez, A.; Hernandez, A.; Herrera, M.; Leon, G.; Macaya, R.; Khüne, A.; Molina-Mora, J. A.; Mora, J.; Sanabria, A.; Sanchez, A.; Sanchez, L.; Segura, A.; Segura, E.; Solano, D.; Soto, C.; Stynoski, J. L.; Vargas, M.; Villalta, M.; Reusken, C.; Drosten, C.; Gutierrez, J. M.; Alape-Giron, A.; Drexler, J. F.
10.1101/2021.06.12.448080 — microbiology — Posted on 2021-06-16
2013 SOD1 Mediates Lysosome-to-Mitochondria Communication and its Dysregulation by Amyloid-β Oligomers
Norambuena, A.; Sun, X.; Wallrabe, H.; Cao, R.; Sun, N.; Pardo, E.; Shivange, N.; Wang, D. B.; Post, L. A.; Ferris, H. A.; Hu, S.; Periasamy, A.; Bloom, G. S.
10.1101/2021.06.14.448281 — neuroscience — Posted on 2021-06-16
2014 Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways
Schlegel, J.; Denay, G.; Pinto, K. G.; Stahl, Y.; Schmid, J.; Blümke, P.; Simon, R. G.
10.1101/2021.06.14.448384 — plant biology — Posted on 2021-06-16
2015 Refining the genomic location of SNP variation affecting Atlantic salmon maturation timing at a key large-effect locus
Sinclair-Waters, M.; Piavchenko, N.; Ruokolainen, A.; Aykanat, T.; Erkinaro, J.; Primmer, C. R.
10.1101/2021.04.26.441431 — genetics — Posted on 2021-06-16
2016 X-ray induced bio-acoustic emissions from cultured cells
Matarese, B.; Rahmoune, H.; Vo, N.; Seymour, C. B.; SCHOFIELD, P.; Mothersill, C. E.
10.1101/2021.06.14.448285 — cell biology — Posted on 2021-06-16
2017 Exposure route, sex, and age influence disease outcome in a golden Syrian hamster model of SARS-CoV-2 infection
Griffin, B. D.; Warner, B. M.; Chan, M.; Mendoza, E. J.; Tailor, N.; Banadyga, L.; Leung, A.; He, S.; Boese, A. S.; Audet, J.; Cao, W.; Moffat, E.; Garnett, L.; Tierney, K.; Tran, K. N.; Albietz, A.; Manguiat, K.; Soule, G.; Bello, A.; Vendramelli, R.; Lin, J.; Deschambault, Y.; Zhu, W.; Safronetz, D.; Wood, H.; Mubareka, S.; Strong, J. E.; Embury-Hyatt, C.; Kobasa, D.
10.1101/2021.06.12.448196 — microbiology — Posted on 2021-06-16
2018 Exploring cell-specific miRNA regulation with single-cell miRNA-mRNA co-sequencing data
Zhang, J.; Liu, L.; Xu, T.; Zhang, W.; Zhao, C.; Li, S.; Li, J.; Rao, N.; Le, T. D.
10.1101/2020.10.14.340299 — bioinformatics — Posted on 2021-06-16
2023 NNAL, a major metabolite of tobacco-specific carcinogen NNK, promotes lung cancer progression through deactivating LKB1 in an isomer-dependent manner
Bian, T.; Wang, Y.; Botello, J. F.; Hu, Q.; Jiang, Y.; Zingone, A.; Corral, P. A.; Aly, F. Z.; Wu, Y.; Ryan, B. M.; Jin, L.; Xing, C.
10.1101/2021.06.15.448557 — cancer biology — Posted on 2021-06-15
2024 The Oncoprotein BCL6 Enables Cancer Cells to Evade Genotoxic Stress
Pang, X.; Liu, Y.; Feng, J.; Yuan, K.; Lu, Y.; Li, K.; Guo, J.; Chen, J.; Ma, C.
10.1101/2021.06.15.448559 — cancer biology — Posted on 2021-06-15
2026 Colorectal cancer progression is potently reduced by a glucose-free, high-protein diet: comparison to anti-EGFR therapy
Skibbe, K.; Brethack, A.-K.; Suenderhauf, A.; Ragab, M.; Raschdorf, A.; Hicken, M.; Schlichting, H.; Preira, J.; Brandt, J.; Castven, D.; Foeh, B.; Pagel, R.; Marquardt, J. U.; Sina, C.; Derer, S.
10.1101/2021.06.15.448354 — cancer biology — Posted on 2021-06-15
2027 Bioengineering a Miniaturized In Vitro 3D Myotube Contraction Monitoring Chip For Modelization of Muscular Dystrophies
Rose, N.; Sonam, S.; Nguyen, T.; Grenci, G.; Bigot, A.; Muchir, A.; Ladoux, B.; Le Grand, F.; Trichet, L.
10.1101/2021.06.15.448543 — bioengineering — Posted on 2021-06-15
2028 Getting more out of co-immunoprecipitation mass spectrometry experiments by reducing interference using FAIMS.
Ang, C.-S.; Sacharz, J.; Leeming, M. G.; Nie, S.; Varshney, S.; Scott, N. E.; Williamson, N. A.
10.1101/2021.06.15.448610 — biochemistry — Posted on 2021-06-15
2030 Tracking SARS-CoV-2 Spike Protein Mutations in the United States (2020/01 - 2021/03) Using a Statistical Learning Strategy
Zhao, L. P.; Lybrand, T. P.; Gilbert, P. B.; Hawn, T. R.; Schiffer, J. T.; Stamatatos, L.; Payne, T. H.; Carpp, L.; Geraghty, D. E.; Jerome, K. R.
10.1101/2021.06.15.448495 — genomics — Posted on 2021-06-15
2031 Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion function for retrotranslocation of ER multi-spanning membrane substrates
Nejatfard, A.; Wauer, N.; Bhaduri, S.; Conn, A.; Gourkanti, S.; Singh, N.; Kuo, T.; Kandel, R. R.; Amaro, R. E.; Neal, S. E.
10.1101/2021.06.15.448428 — cell biology — Posted on 2021-06-15
2032 Extracellular RNA moves from the glomerulus to the renal tubule
Hunter, R. W.; Kumar, S.; Coward, R. J.; Buck, A. H.; Dear, J. W.
10.1101/2021.06.15.448584 — molecular biology — Posted on 2021-06-15
2033 Cyanolichen microbiome contains novel viruses that encode genes to promote microbial metabolism
Ponsero, A. J.; Hurwitz, B. L.; Magain, N.; Miadlikowska, J.; Lutzoni, F.; U'Ren, J. M.
10.1101/2021.06.15.448434 — microbiology — Posted on 2021-06-15
2035 Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action
Grima, L. L.; Panayi, M. C.; Harmson, O.; Syed, E.; Manohar, S. G.; Husain, M.; Walton, M. E.
10.1101/2021.06.15.448563 — neuroscience — Posted on 2021-06-15
2037 Acetylation of conserved lysines fine-tune mitochondrial malate dehydrogenase activity in land plants
Balparda, M.; Elsässer, M.; Badia, M.; Giese, J.; Bovdilova, A.; Hüdig, M.; Reinmuth, L.; Schwarzländer, M.; Finkemeier, I.; Schallenberg-Rüdinger, M.; Maurino, V. G.
10.1101/2020.10.30.362046 — plant biology — Posted on 2021-06-15
2044 Genome instability drives epistatic adaptation in the human pathogen Leishmania
Bussotti, G.; Piel, L.; Pescher, P.; Domagalska, M. A.; Rajan, K. S.; Doniger, T.; Hiregange, D. G.; Myler, P. J.; Unger, R.; Michaeli, S. J.; Spaeth, G. F.
10.1101/2021.06.15.448517 — genomics — Posted on 2021-06-15
2045 Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes
Dicks, A. R.; Maksaev, G. I.; Harissa, Z.; Savadipour, A.; Tang, R.; Steward, N.; Liedtke, W.; Wu, C.-L.; Guilak, F.
10.1101/2021.06.15.448562 — developmental biology — Posted on 2021-06-15
2046 Novel Role of UHRF1 in DNA methylation-mediated repression of latent HIV-1
Verdikt, R.; Bouchat, S.; Pasternak, A. O.; Nestola, L.; Darcis, G.; Avettand-Fenoel, V.; Vanhulle, C.; Ait-Ammar, A.; Bendoumou, M.; Plant, E.; Le Douce, V.; Delacourt, N.; Cicilionyte, A.; Necsoi, C.; Corazza, F.; Pereira Bittencourt Passaes, C.; Schwartz, C.; Bizet, M.; Fuks, F.; Saez-Cirion, A.; Rouzioux, C.; De Wit, S.; Berkhout, B.; Gautier, V.; ROHR, O.; Van Lint, C.
10.1101/2021.06.15.448539 — microbiology — Posted on 2021-06-15
2048 Carbonyl Post-Translational Modification Associated with Early Onset Type 1 Diabetes Autoimmunity
Yang, M.-L.; Connolly, S.; Gee, R.; Lam, T.; Kanyo, J.; Clarke, S. G.; Clarke, C. F.; James, E. A.; Speake, C.; Evans-Molina, C.; Wen, L.; Herold, K. C.; Mamula, M.
10.1101/2021.06.15.448522 — immunology — Posted on 2021-06-15
2049 Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency
Milardi, G.; Di Lorenzo, B.; Gerosa, J.; Barzaghi, F.; Di Matteo, G.; Omrani, M.; Jofra, T.; Merelli, I.; Barcella, M.; Ferrua, F.; Giuffrida, F. P.; Dionisio, F.; Rovere-Querini, P.; Marktel, S.; Assanelli, A.; Piemontese, S.; Brigida, I.; Zoccolillo, M.; Cirillo, E.; Giardino, G.; Danieli, M. G.; Specchia, F.; Pacillo, L.; Di Cesare, S.; Giancotta, C.; Romano, F.; Matarese, A.; Chetta, A. A.; Trimarchi, M.; Laurenzi, A.; De Pellegrin, M.; Darin, S.; Montin, D.; Dellepiane, R. M.; Sordi, V.; Lougaris, V.; Vacca, A.; Melzi, R.; Nano, R.; Azzari, C.; Bongiovanni, L.; Pignata, C.; Cancrini, C.;
10.1101/2021.06.15.448353 — immunology — Posted on 2021-06-15
2050 Changes at V2 apex of HIV-1 Clade C trimer enhance elicitation of autologous neutralizing and broad V1V2-scaffold antibodies
Sahoo, A.; Hodge, E. A.; LaBranche, C.; Styles, T. T.; Shen, X.; Cheedarla, N.; Shiferaw, A.; Ozorowski, G.; Lee, W.-H.; Ward, A. B.; Tomaras, G. D.; Montefiori, D. C.; Irvine, D. J.; Lee, K. K.; Amara, R. R.
10.1101/2021.06.15.447100 — immunology — Posted on 2021-06-15
2052 The ascending arousal system promotes optimal performance through meso-scale network integration in a visuospatial attentional task
Wainstein, G.; Rojas-Libano, D.; Medel, V.; Alnaes, D.; Kolskar, K. K.; Endestad, T.; Laeng, B.; Ossandon, T.; Crossley, N.; Matar, E.; Shine, J.
10.1101/2020.12.04.412551 — neuroscience — Posted on 2021-06-15
2054 Reproducibility of protein X-ray diffuse scattering and potential utility for modeling atomic displacement parameters
Su, Z.; Dasgupta, M.; Poitevin, F.; Mathews, I. I.; van den Bedem, H.; Wall, M. E.; Yoon, C. H.; Wilson, M. A.
10.1101/2021.01.24.428002 — biophysics — Posted on 2021-06-15
2056 Measuring mitochondrial electron transfer complexes in previously frozen cardiac tissue from the offspring of sow: A model to assess exercise induced mitochondrial bioenergetics changes
Barrera, D.; Upton, S.; Rauch, M.; Notarianni, T.; Eum, K. S.; Liberty, M.; Liu, R.; Newcomer, S.; May, L. E.; Agbas, E.; Sage, J.; Kosa, E.; Agbas, A.
10.1101/2021.06.08.447578 — biochemistry — Posted on 2021-06-15
2057 Novel intracellular phospholipase B from Pseudomonas aeruginosa with activity towards endogenous phospholipids affects biofilm assembly
Weiler, A. J.; Spitz, O.; Gudzuhn, M.; Schott-Verdugo, S. N.; Kamel, M.; Thiele, B.; Wolfgang, S.; Kedrov, A.; Schmitt, L.; Gohlke, H.; Kovacic, F.
10.1101/2021.06.15.448513 — biochemistry — Posted on 2021-06-15
2058 A novel DNA binding mode, conformational change and intramolecular signaling in MutS upon mismatch recognition in replication DNA structures
Ibanez, M. I.; Margara, L. M.; Castell, S. D.; Fernandez, M. M.; Malchiodi, E. L.; Montich, G. G.; Miguel, V.; Argarana, C. E.; Monti, M. R.
10.1101/2020.05.01.070730 — biochemistry — Posted on 2021-06-15
2064 Translesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos
Lo Furno, E.; Busseau, I.; Lorenzi, C.; Saghira, C.; Danzi, M. C.; Zuchner, S.; Maiorano, D.
10.1101/2020.11.28.401471 — developmental biology — Posted on 2021-06-15
2067 Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam
Hirabayashi, A.; Yahara, K.; Mitsuhashi, S.; Nakagawa, S.; Imanishi, T.; Ha, V. T. T.; Nguyen, A. V.; Nguyen, S. T.; Shibayama, K.; Suzuki, M.
10.1101/2020.03.18.996710 — microbiology — Posted on 2021-06-15
2069 Genomic features of Mycobacterium avium subsp. hominissuis isolated from pigs in Japan.
MARUYAMA, F.; Komatsu, T.; Ohya, K.; Ota, A.; Nishiuchi, Y.; Yano, H.; Matsuo, K.; Odoi, J. O.; Suganuma, S.; Sawai, K.; Hasebe, A.; Asai, T.; Yanai, T.; Fukushi, H.; Wada, T.; Yoshida, S.; Ito, T.; Arikawa, K.; Kawai, M.; Ato, M.; Baughn, A. D.; Iwamoto, T.
10.1101/2021.06.15.447579 — microbiology — Posted on 2021-06-15
2070 Ehrlichia ruminantium uses its transmembrane protein Ape to adhere to host bovine aortic endothelial cells
Pinarello, V.; Bencurova, E.; Marcelino, I.; Gros, O.; Puech, C.; Bhide, M.; Vachiery, N.; MEYER, D. F.
10.1101/2021.06.15.447525 — microbiology — Posted on 2021-06-15
2073 U-RISC: An Ultra-high Resolution EM Dataset Challenging Existing Deep Learning Algorithms
Shi, R.; Wang, W.; Li, Z.; He, L.; Sheng, K.; Ma, L.; Du, K.; Jiang, T.; Huang, T.
10.1101/2021.05.30.446334 — neuroscience — Posted on 2021-06-15
2076 Zinc2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro.
Panchariya, L.; Khan, W. A.; Kuila, S.; Sonkar, K.; Sahoo, S.; Ghoshal, A.; Kumar, A.; Verma, D. K.; Hasan, A.; Das, S.; Thakur, J. K.; Halder, R.; Sunil, S.; Arulandu, A.
10.1101/2021.06.15.448551 — biochemistry — Posted on 2021-06-15
2077 RASSF1A independence and early Galectin-1 upregulation in PIK3CA induced hepatocarcinogenesis: new therapeutic venues
Scheiter, A.; Evert, K.; Reibenspies, L.; Cigliano, A.; Annweiler, K.; Mueller, K.; Poehmerer, L.-M.-G.; Itzel, T.; Materna-Reichelt, S.; Coluccio, A.; Honarnejad, K.; Teufel, A.; Brochhausen, C.; Dombrowski, F.; Chen, X.; Evert, M.; Calvisi, D.; Utpatel, K.
10.1101/2021.06.15.448477 — pathology — Posted on 2021-06-15
2079 Molecular dynamics analysis of fast-spreading severe acute respiratory syndrome coronavirus 2 variants and their effects in the interaction with human angiotensin-converting enzyme 2
Souza, A. S. d.; Amorim, V. M. d. F.; Guardia, G. D. A.; Santos, F. R. C. d.; Santos, F. F. d.; de Souza, R. F.; Juvenal, G. d. A.; Huang, Y.; Ge, P.; Jiang, Y.; Paudel, P.; Ulrich, H.; Galante, P. A. F.; Guzzo, C. R.
10.1101/2021.06.14.448436 — molecular biology — Posted on 2021-06-15
2080 Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures
Roden, C.; Dai, Y.; Seim, I.; Lee, M.; Sealfon, R.; McLaughlin, G.; Boerneke, M.; Iserman, C.; Wey, S. A.; Ekena, J. L.; Troyanskaya, O. G.; Weeks, K.; You, L.; Chilkoti, A.; Gladfelter, A.
10.1101/2021.06.14.448452 — molecular biology — Posted on 2021-06-15
2081 Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection: AXL as a Therapeutic Target for COVID-19
Bohan, D.; Van Ert, H.; Ruggio, N.; Rogers, K. J.; Baddredine, M.; Briseno, J. A. A.; Rojas Chavez, R. A.; Gao, B.; Stokowy, T.; Christakou, E.; Micklem, D.; Gausdal, G.; Haim, H.; Minna, J.; Lorens, J. B.; Maury, W.
10.1101/2021.06.15.448419 — microbiology — Posted on 2021-06-15
2082 A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence
Spencer, B. L.; Tak, U.; Mendonca, J. C.; Nagao, P. E.; Niederweis, M.; Doran, K. S.
10.1101/2021.06.15.448449 — microbiology — Posted on 2021-06-15
2083 Synthetic Natural Product-Inspired Peptides
Hostetler, M.; Smith, C.; Nelson, S.; Budimir, Z.; Modi, R.; Woolsey, I.; Frerk, A.; Baker, B.; Gantt, J.; Parkinson, E. I.
10.1101/2021.06.15.448394 — microbiology — Posted on 2021-06-15
2086 Multi-Dimensional Reduction Clustering of Complex Carbohydrates Reveal Tissue Metabolism, Heterogeneity and Histopathology
Conroy, L. R.; Allison, D. B.; Sun, Q.; Young, L. E.; Hawkinson, T. R.; Clarke, H. A.; Ferreira, J. E.; Hammonds, A. V.; McDonald, R. J.; Absher, K. J.; Alilain, W. J.; Waters, C. M.; Liu, J.; Sun, R. C.
10.1101/2021.06.14.448358 — systems biology — Posted on 2021-06-15
2090 Systematic Chromosome Rearrangement Induced by CRISPR-Cas9 Reshapes the Genome and Transcriptome of Human Cells
Liu, Y.; Ma, G.; Gao, Z.; Li, J.; Wang, J.; Zhu, X.; Yang, J.; Zhou, Y.; Hu, K.; Zhang, Y.; GUO, Y.
10.1101/2021.06.15.448470 — genomics — Posted on 2021-06-15
2092 Stem cell therapy for skin regeneration using mesenchymal stem cells derived from the progeroid Werner syndrome-specific iPS cells
Funayama, S.; Kato, H.; Kaneko, H.; Kosaka, K.; Sawada, D.; Takada-Watanabe, A.; Minamizuka, T.; Baba, Y.; Koshizaka, M.; Shimamoto, A.; Ouchi, Y.; Iwama, A.; Endo, Y.; Takayama, N.; Eto, K.; Maezawa, Y.; Yokote, K.
10.1101/2021.06.15.448474 — cell biology — Posted on 2021-06-15
2093 Senescence inhibits the chaperone response to thermal stress
Llewellyn, J.; Mallikarjun, V.; Appleton, E.; Osipova, M.; Gilbert, H. T.; Richardson, S. M.; Hubbard, S. J.; Swift, J.
10.1101/2021.06.15.448532 — cell biology — Posted on 2021-06-15
2096 The SARS-CoV-2 nucleocapsid protein associates with the replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress
Scherer, K. M.; Mascheroni, L.; Carnell, G. W.; Wunderlich, L. C. S.; Makarchuk, S.; Brockhoff, M.; Mela, I.; Fernandez-Villegas, A.; Barysevich, M.; Stewart, H.; Suau Sans, M.; George, C. L.; Lamb, J. R.; Kaminski Schierle, G. S.; Heeney, J. L.; Kaminski, C. F.
10.1101/2021.06.15.448497 — microbiology — Posted on 2021-06-15
2097 Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2
Tostanoski, L.; Gralinski, L.; Martinez, D.; Schaefer, A.; Mahrokhian, S.; Li, Z.; Nampanya, F.; Wan, H.; Yu, J.; Chang, A.; Liu, J.; McMahan, K.; Dinnon, K.; Leist, S. R.; Baric, R. S.; Barouch, D. H.
10.1101/2021.06.14.448461 — microbiology — Posted on 2021-06-15
2098 Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation
Moshkelgosha, S.; Duong, A.; Wilson, G.; Andrews, T.; Berra, G.; Renaud-Picard, B.; Liu, M.; Keshavjee, S.; MacParland, S.; Yeung, J.; Martinu, T.; Juvet, S. C.
10.1101/2021.06.14.447967 — immunology — Posted on 2021-06-15
2101 Discovery and mechanism of action of small molecule inhibitors of ceramidases
Granier, S.; Healey, R. D.; Saied, E.; Cong, X.; Karsai, G.; Gabellier, L.; Saint-Paul, J.; Del Nero, E.; Jeannot, S.; Drapeau, M.; Fontanel, S.; Maurel, D.; Basu, S.; LEYRAT, C.; Bossis, G.; BECHARA, C.; Hornemann, T.; Arenz, C.
10.1101/2021.06.15.448479 — biochemistry — Posted on 2021-06-15
2103 Effect of Substrate Stiffness on Human Intestinal Enteroids Infectivity by Enteroaggregative Escherichia coli
Swaminathan, G.; Kamyabi, N.; Carter, H.; Rajan, A.; Karandikar, U.; Criss, Z.; Shroyer, N. F.; Robertson, M.; Coarfa, C.; Huang, C.; Shannon, T.; Tadros, M.; Estes, M.; Maresso, A.; Grande-Allen, K. J.
10.1101/2021.06.15.448533 — bioengineering — Posted on 2021-06-15
2107 Accurate prediction of protein structures and interactions using a 3-track network
Baek, M.; DiMaio, F.; Anishchenko, I.; Dauparas, J.; Ovchinnikov, S.; Lee, G. R.; Wang, J.; Cong, Q.; Kinch, L. N.; Schaeffer, R. D.; Millan, C.; Park, H.; Adams, C.; Glassman, C. R.; DeGiovanni, A.; Pereira, J. H.; Rodrigues, A. V.; van Dijk, A. A.; Ebrecht, A. C.; Opperman, D. J.; Sagmeister, T.; Buhlheller, C.; Pavkov-Keller, T.; Rathinaswamy, M. K.; Dalwadi, U.; Yip, C. K.; Burke, J. E.; Garcia, K. C.; Grishin, N. V.; Adams, P. D.; Read, R. J.; Baker, D.
10.1101/2021.06.14.448402 — bioinformatics — Posted on 2021-06-15
2109 Mouse models of immune dysfunction: Their neuroanatomical differences reflect their anxiety-behavioural phenotype
Fernandes, D. J.; Spring, S.; Corre, C.; Tu, A.; Qiu, L.; Hammill, C.; Vousden, D. A.; Spencer Noakes, T. L.; Nieman, B. J.; Bowdish, D. M. E.; Foster, J. A.; Palmert, M. R.; Lerch, J. P.
10.1101/2021.06.14.448406 — neuroscience — Posted on 2021-06-15
2111 Modeling progression of single cell populations through the cell cycle as a sequence of switches
Zinovyev, A.; Sadovsky, M.; Calzone, L.; Fouche, A.; Groeneveld, C. S.; Barillot, E.; Gorban, A. N.
10.1101/2021.06.14.448414 — systems biology — Posted on 2021-06-15
2112 Enhancing Sampling of Water Rearrangements on Ligand Binding: A Comparison of Techniques
Ge, Y.; Wych, D. C.; Samways, M. L.; Wall, M. E.; Essex, J. W.; Mobley, D. L.
10.1101/2021.06.14.448350 — biophysics — Posted on 2021-06-15
2113 OsciDrop: A versatile on-demand droplet generator
Ye, S.; Zheng, X.; Li, C.; Huang, W.; Tao, Y.; Yu, Y.; Yang, L.; Lan, Y.; Ma, L.; Bian, S.; Du, W.
10.1101/2021.06.14.448273 — bioengineering — Posted on 2021-06-15
2114 Engineered small extracellular vesicles as a FGL1/PD-L1 dual-targeting delivery system for alleviating immune rejection
Tsai, H.-i.; Wu, Y.; Liu, X.; Xu, Z.; Liu, L.; Huang, Y.; Wang, L.; Zhang, W.; Zhang, H.; Su, D.; Khan, F. U.; Wang, C.; Eriksson, J. E.; Jia, B.; Cheng, F.; Chen, H.
10.1101/2021.06.14.448282 — bioengineering — Posted on 2021-06-15
2115 Application of ATAC-Seq for genome-wide analysis of the chromatin state at single myofiber resolution
Sahinyan, K.; Blackburn, D. M.; Simon, M.-M.; Lazure, F.; Kwan, T.; Bourque, G.; Soleimani, V. D.
10.1101/2021.06.14.448380 — genetics — Posted on 2021-06-15
2118 300 years of change for native fish species in the upper Danube River Basin - historical flow alterations versus future climate change
Friedrichs-Manthey, M.; Langhans, S. D.; Borgwardt, F.; Hein, T.; Stanzel, P.; Kling, H.; Jaehnig, S. C.; Domisch, S.
10.1101/2021.06.14.448400 — ecology — Posted on 2021-06-15
2122 Regulation of auditory fear discrimination by the novel Kv3 voltage-gated potassium channel modulator AUT00206
Stubbendorff, C.; Hale, E.; Day, H. L. L.; Smith, J.; Alvaro, G. S.; Large, C. H.; Stevenson, C. W.
10.1101/2021.06.15.448180 — neuroscience — Posted on 2021-06-15
2124 Early mismatch between cancer cells and their tumour microenvironment blocks long term growth
Perdrix Rosell, A.; Maiques, O.; Chakravarty, P.; Ombrato, L.; Sanz-Moreno, V.; Malanchi, I.
10.1101/2021.06.15.448466 — cancer biology — Posted on 2021-06-15
2125 Deep learning trained on H&E tumor ROIs predicts HER2 status and Trastuzumab treatment response in HER2+ breast cancer
farahmand, s.; Fernandez, A.; Ahmed, F. S.; Rimm, D.; Chuang, J. H.; Reisenbichler, E.; Zarringhalam, K.
10.1101/2021.06.14.448356 — bioinformatics — Posted on 2021-06-15
2126 Klarigi: Explanations for Semantic Groupings
Slater, L. T.; Williams, J. A.; Karwath, A.; Russell, S.; Pendleton, S. C.; Fanning, H.; Ball, S.; Schofield, P.; Hoehndorf, R. T.; Gkoutos, G. V.
10.1101/2021.06.14.448423 — bioinformatics — Posted on 2021-06-15
2128 Sequencing uracil in DNA at single-nucleotide resolution
Jiang, L.; Yin, J.; Qian, M.; Rong, S.; Chen, K.; Zhao, C.; Tan, Y.; Guo, J.; Chen, H.; Gao, S.; Liu, T.; Liu, Y.; Shen, B.; Yang, J.; Zhang, Y.; Meng, F.-L.; Hu, J.; Ma, H.; Chen, Y.-H.
10.1101/2021.06.14.448445 — biochemistry — Posted on 2021-06-15
2131 miR-486 is an epigenetic modulator of Duchenne muscular dystrophy pathologies
Hightower, R. M.; Samani, A.; Reid, A. L.; English, K. G.; Lopez, M. A.; Doyle, J. S.; Conklin, M. J.; Schneider, D. A.; Bamman, M. M.; Widrick, J. J.; Crossman, D.; Xie, M.; Jee, D.; Lai, E. C.; Alexander, M. S.
10.1101/2021.06.14.448387 — genetics — Posted on 2021-06-15
2133 Phase-separated stress granules and processing bodies are compromised in Myotonic Dystrophy Type 1
Gulyurtlu, S.; Magon, M. S.; Guest, P.; Papavasiliou, P. P.; Prescott, A. R.; Sleeman, J. E.
10.1101/2021.06.14.448303 — cell biology — Posted on 2021-06-15
2134 Profiling the in vitro and in vivo activity of streptothricin-F against carbapenem-resistant Enterobacterales: a historic scaffold with a novel mechanism of action
Smith, K. P.; Kang, Y.-S.; Green, A. B.; Dowgiallo, M. G.; Miller, B. C.; Chiaraviglio, L.; Truelson, K. A.; Zulauf, K. E.; Rodriguez, S.; Manetsch, R.; Kirby, J. E.
10.1101/2021.06.14.448463 — microbiology — Posted on 2021-06-15
2135 The IL-33-ILC2 pathway protects from amebic colitis
Uddin, M. J.; Leslie, J. L.; Burgess, S. L.; Okland, N.; Thompson, B.; Abhyankar, M.; Frisbee, A.; Donlan, A. N.; Kumar, P.; Petri, W. A.
10.1101/2021.06.14.448450 — immunology — Posted on 2021-06-15
2136 Distributional reinforcement learning in prefrontal cortex
Muller, T. H.; Butler, J. L.; Veselic, S.; Miranda, B.; Behrens, T. E. J.; Kurth-Nelson, Z.; Kennerley, S. W.
10.1101/2021.06.14.448422 — neuroscience — Posted on 2021-06-15
2137 Value-based decision-making between affective memories
Pulcu, E.; Guinea, C.; Clemens, H.; Harmer, C. J.; Murphy, S. E.
10.1101/2021.06.14.448275 — neuroscience — Posted on 2021-06-15
2138 Single-synapse analyses of Alzheimers disease implicate pathologic tau, DJ1, CD47, and ApoE
Phongpreecha, T.; Gajera, C. R.; Liu, C. C.; Vijayaragavan, K.; Chang, A. L.; Becker, M.; Fallahzadeh, R.; Fernandez, R.; Postupna, N.; Sherfield, E.; Tebaykin, D.; Latimer, C.; Shively, C. A.; Register, T. C.; Craft, S.; Montine, K. S.; Fox, E. J.; Poston, K. L.; Keene, C. D.; Angelo, M.; Bendall, S. C.; Aghaeepour, N.; Montine, T. J.
10.1101/2021.06.14.448240 — neuroscience — Posted on 2021-06-15
2141 Dynamic autonomic nervous system patterns differentiate human emotions and manifest in resting physiology
Pasquini, L.; Noohi, F.; Veziris, C. R.; Kosik, E. L.; Holley, S. R.; Lee, A.; Brown, J. A.; Roy, A. R. K.; Chow, T. E.; Allen, I.; Rosen, H. J.; Kramer, J. H.; Miller, B. L.; Saggar, M.; Seeley, W. W.; Sturm, V. E.
10.1101/2021.06.14.448456 — neuroscience — Posted on 2021-06-15
2148 Cross-species metabolomic analysis of DDT and Alzheimer's disease-associated tau toxicity
Kalia, V.; Niedzwiecki, M. M.; Bradner, J. M.; Lau, F. K.; Bucher, M. L.; Manz, K. E.; Coates Fuentes, Z.; Pennell, K. D.; Picard, M.; Walker, D. I.; Hu, W. T.; Jones, D. P.; Miller, G. W.
10.1101/2021.06.14.448355 — pharmacology and toxicology — Posted on 2021-06-15
2151 FlyPhoneDB: An integrated web-based resource for cell-cell communication prediction in Drosophila
Liu, Y.; Hu, Y.; Li, J. S. S.; Rodiger, J.; Comjean, A.; Attrill, H.; Antonazzo, G.; Brown, N. H.; Perrimon, N.
10.1101/2021.06.14.448430 — bioinformatics — Posted on 2021-06-15
2152 Targeting a proteolytic neo-epitope of CUB-domain containing protein 1 in RAS-driven cancer
Lim, S. A.; Zhou, J.; Martinko, A. J.; Wang, Y.-H.; Filippova, E. V.; Steri, V.; Wang, D.; Remesh, S. G.; Liu, J.; Hann, B.; Kossiakoff, A. A.; Evans, M. J.; Leung, K. K.; Wells, J. A.
10.1101/2021.06.14.448427 — biochemistry — Posted on 2021-06-15
2153 X-ray induced bio-acoustic emissions from cultured cells
Matarese, B.; Rahmoune, H.; Vo, N.; Seymour, C. B.; SCHOFIELD, P.; Mothersill, C. E.
10.1101/2021.06.14.448285 — cell biology — Posted on 2021-06-15
2165 Synergistic inhibition of two host factors that facilitate entry of Severe Acute Respiratory Syndrome Coronavirus 2
Kreutzberger, A. J. B.; Sanyal, A.; Ojha, R.; Pyle, J.; Vapalahti, O.; Balistreri, G.; Kirchhausen, T.
10.1101/2021.06.01.446623 — microbiology — Posted on 2021-06-15
2169 Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen
Saul, S.; Karim, M.; Huang, P.-T.; Ghita, L.; Chiu, W.; Kumar, S.; Bhalla, N.; Leyssen, P.; Cohen, C. A.; Huie, K. E.; Tindle, C.; Sibai, M.; Pinsky, B. A.; Das, S.; Ghosh, P.; Dye, J.; Solow-Cordero, D. E.; Jin, J.; Jochmans, D.; Neyts, J.; Narayanan, A.; De Jonghe, S.; Einav, S.
10.1101/2021.05.15.444128 — microbiology — Posted on 2021-06-15
2176 Dissecting the molecular basis of human interneuron migrationin forebrain assembloids from Timothy syndrome
Birey, F.; Li, M.-Y.; Gordon, A.; Thete, M.; Valencia, A. M.; Revah, O.; Pasca, A. M.; Geschwind, D. H.; Pasca, S. P.
10.1101/2021.06.14.448277 — neuroscience — Posted on 2021-06-15
2177 Functional disruption of Transferrin expression alters reproductive physiologyin Anopheles culicifacies
Dixit, R.; rani, j.; De, T. D.; chauhan, C.; kumari, S.; sharma, P.; tevatia, S.; Chakraborti, S.; pandey, K. C.; singh, N.
10.1101/2021.06.14.448311 — molecular biology — Posted on 2021-06-14
2178 Protein Domain-Based Prediction of Compound-Target Interactions and Experimental Validation on LIM Kinases
Dogan, T.; Akhan Güzelcan, E.; Baumann, M.; Koyas, A.; Atas, H.; Baxendale, I.; Martin, M.; Cetin-Atalay, R.
10.1101/2021.06.14.448307 — bioinformatics — Posted on 2021-06-14
2182 Regulation Network of Colorectal Cancer Specific Enhancers in Progression of Colorectal Cancer
Chen, B.; Ma, Y.; Bi, J.; Wang, W.; He, A.; Su, G.; Zhao, Z.; Shi, J.; Zhang, L.
10.1101/2021.06.14.448310 — genetics — Posted on 2021-06-14
2183 Evolution of the nitric oxide synthase family in vertebrates and novel insights in gill development
Annona, G.; Sato, I.; Pascual-Anaya, J.; Braasch, I.; Voss, R.; Stundl, J.; Soukup, V.; Kuratani, S.; Postlethwait, J.; D'Aniello, S.
10.1101/2021.06.14.448362 — evolutionary biology — Posted on 2021-06-14
2184 Distinct gene expression dynamics in developing and regenerating limbs
Sinigaglia, C.; Almazan, A.; Semon, M.; Gillet, B.; Hughes, S.; Edsinger, E.; Averof, M.; Paris, M.
10.1101/2021.06.14.448408 — developmental biology — Posted on 2021-06-14
2186 A thermal fuse in methionine biosynthesis arrests growth and protects Escherichia coli at elevated temperatures
Schink, S. J.; Gough, Z. H.; Biselli, E.; Huiman, M. G.; Chang, Y.-F.; Basan, M.; Gerland, U.
10.1101/2021.06.14.448417 — microbiology — Posted on 2021-06-14
2188 I, We, and They: A Linguistic and Narrative Exploration of the Authorship Process
Konopasky, A.; O'Brien, B. C.; Artino, A. R.; Driessen, E. W.; Watling, C. J.; Maggio, L. A.
10.1101/2021.06.14.448236 — scientific communication and education — Posted on 2021-06-14
2190 Reproducibility of protein X-ray diffuse scattering and potential utility for modeling atomic displacement parameters
Su, Z.; Dasgupta, M.; Poitevin, F.; Mathews, I. I.; van den Bedem, H.; Wall, M. E.; Yoon, C. H.; Wilson, M. A.
10.1101/2021.01.24.428002 — biophysics — Posted on 2021-06-14
2191 Mapping the Genetic Landscape of DNA Double-strand Break Repair
Hussmann, J. A.; Ling, J.; Ravisankar, P.; Yan, J.; Cirincione, A.; Xu, A.; Simpson, D.; Yang, D.; Bothmer, A.; Cotta-Ramusino, C.; Weissman, J. S.; Adamson, B.
10.1101/2021.06.14.448344 — genomics — Posted on 2021-06-14
2197 CXCR6 by increasing retention of memory CD8 T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer
Muthuswamy, R.; McGray, A. R.; Battaglia, S.; He, W.; Miliotto, A.; Eppolito, C. A.; Litchy, B. D.; Shrikant, P.; Odunsi, K.; Odunsi, K.
10.1101/2020.12.02.401729 — immunology — Posted on 2021-06-14
2198 A novel and accurate full-length HTT mouse model for Huntington's disease
Li, C.; Zheng, S.; Shenoy, S. A.; Liu, W.; Dai, Y.; Liu, Y.; Hou, Z.; Mori, S.; Duan, W.
10.1101/2021.06.14.448318 — neuroscience — Posted on 2021-06-14
2201 Ultrafast Light Targeting for High-Throughput Precise Control of Neuronal Networks
Faini, G.; Molinier, C.; Telliez, C.; Tourain, C.; Forget, B. C.; Ronzitti, E.; Emiliani, V.
10.1101/2021.06.14.448315 — neuroscience — Posted on 2021-06-14
2206 Rapamycin induced hyperglycemia is associated with exacerbated age-related osteoarthritis
Minton, D. M.; Elliehausen, C. J.; Javors, M. A. M.; Santangelo, K. S.; Konopka, A. R.
10.1101/2021.05.21.445179 — physiology — Posted on 2021-06-14
2207 Deep learning-based segmentation and quantification of podocyte foot process morphology
Butt, L.; Unnersjoe-Jess, D.; Hoehne, M.; Sergei, G.; Witasp, A.; Wernerson, A.; Patrakka, J.; Hoyer, P. F.; Blom, H.; Schermer, B.; Bozek, K.; Benzing, T.
10.1101/2021.06.14.448284 — pathology — Posted on 2021-06-14
2214 Generalization of Cortical MOSTest Genome-Wide Associations Within and Across Samples
Loughnan, R. J.; Shadrin, A. A.; Frei, O.; van der Meer, D.; Zhao, W.; Palmer, C. E.; Thompson, W. E.; Makowski, C.; Jernigan, T.; Andreassen, O.; Fan, C. C.; Dale, A.
10.1101/2021.04.23.441215 — genomics — Posted on 2021-06-14
2219 Recurrent Emergence of an Antiviral Defense through Repeated Retrotransposition and Truncation of CHMP3
Rheinemann, L.; Downhour, D. M.; Davenport, K. A.; McKeown, A. N.; Sundquist, W. I.; Elde, N. C.
10.1101/2021.04.27.441704 — evolutionary biology — Posted on 2021-06-14
2227 TDAExplore: quantitative image analysis through topology-based machine learning
Edwards, P.; Skruber, K.; Milicevic, N.; Heidings, J. B.; Read, T.-A.; Bubenik, P.; Vitriol, E. A.
10.1101/2021.06.13.448249 — cell biology — Posted on 2021-06-14
2231 Reciprocal Priming between RTKs at Recycling Endosomes Orchestrates Cellular Signaling Outputs
Smith, M. P.; Ferguson, H. R.; Ferguson, J.; Zindy, E.; Kowalczyk, K. M.; Kedward, T.; Bates, C.; Parsons, J.; Watson, J.; Chandler, S.; Fullwood, P.; Warwood, S.; Knight, D.; Clarke, R. B.; Francavilla, C.
10.1101/2021.01.04.425243 — cell biology — Posted on 2021-06-14
2232 CENP-N promotes the compaction of centromeric chromatin
Zhou, K.; Gebala, M.; Woods, D. C.; Sundararajan, K.; Edwards, G.; Krzizike, D.; Wereszczynski, J.; Straight, A. F.; Luger, K.
10.1101/2021.06.14.448351 — molecular biology — Posted on 2021-06-14
2233 A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich's Ataxia
Campos, O. A.; Attar, N.; Mallipeddi, N. V.; Cheng, C.; Vogelauer, M.; Schmollinger, S.; Merchant, S. S.; Kurdistani, S. K.
10.1101/2021.06.14.448268 — molecular biology — Posted on 2021-06-14
2234 Selective nuclear export of mRNAs is promoted by DRBD18 in Trypanosoma brucei
Mishra, A.; Kaur, J. N.; McSkimming, D. I.; Hegedusova, E.; Dubey, A. P.; Ciganda, M.; Paris, Z.; Read, L. K.
10.1101/2021.06.14.448361 — microbiology — Posted on 2021-06-14
2235 Practical observations on the use of fluorescent reporter systems in C. difficile
Oliveira Paiva, A. M.; Friggen, A. H.; Douwes, R.; Wittekoek, B.; Smits, W. K.
10.1101/2021.06.14.448366 — microbiology — Posted on 2021-06-14
2236 Expanding Clinical Phage Microbiology:‎Simulating Phage Inhalation for Respiratory Tract Infections ‎
Ben-Porat, S.; Gelman, D.; Yerushalmy, O.; Alkalay-Oren, S.; Coppenhagen-Glazer, S.; Cohen-Cymberknoh, M.; Kerem, E.; Amirav, I.; Nir-Paz, R.; Hazan, R.
10.1101/2021.06.14.448272 — microbiology — Posted on 2021-06-14
2241 Mapping Brain-Behavior Space Relationships Along the Psychosis Spectrum
Ji, J. L.; Helmer, M.; Fonteneau, C.; Burt, J. B.; Tamayo, Z.; Demsar, J.; Adkinson, B.; Savic, A.; Preller, K.; Moujaes, F.; Vollenweider, F. X.; Martin, W.; Repovs, G.; Murray, J. D.; Anticevic, A.
10.1101/2020.09.15.267310 — neuroscience — Posted on 2021-06-14
2246 Mechanosensory trichome cells evoke a mechanical stimuli-induced immune response in plants
Matsumura, M.; Nomoto, M.; Itaya, T.; Aratani, Y.; Iwamoto, M.; Matsuura, T.; Hayashi, Y.; Kinoshita, T.; Mori, I.; Suzuki, T.; Betsuyaku, S.; Spoel, S. H.; Toyota, M.; Tada, Y.
10.1101/2021.06.13.448005 — plant biology — Posted on 2021-06-14
2247 HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage independence
Kim, Y. S.; Welles, J. E.; Tang, P. W.; Javed, Z.; Elhaw, A. T.; Mythreye, K.; Kimball, S. R.; Hempel, N.
10.1101/2021.02.19.432010 — cancer biology — Posted on 2021-06-14
2248 Designer Scaffolds for Bioengineered Tissue Interfaces
Hickey, R. J.; Leblanc Latour, M.; Harden, J. L.; Pelling, A.
10.1101/2020.11.06.371278 — biophysics — Posted on 2021-06-14
2255 Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243A>G mtDNA mutation
Chung, C.-Y.; Singh, K.; Kotiadis, V. N.; Valdebenito, G. E.; Ahn, J. H.; Topley, E.; Tan, J.; Andrews, W. D.; Bilanges, B.; Pitceathly, R. D. S.; Szabadkai, G.; Yuneva, M.; Duchen, M. R.
10.1101/2020.06.18.159103 — cell biology — Posted on 2021-06-14
2256 Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
Rausser, S.; Trumpff, C.; McGill, M. A.; Junker, A.; Wang, W.; Ho, S.-H.; Mitchell, A.; Karan, K. R.; Monk, C.; Segerstrom, S. C.; Reed, R. G.; Picard, M.
10.1101/2020.10.16.342923 — cell biology — Posted on 2021-06-14
2257 Structural dynamics of the functional nonameric Type III translocase export gate
Yuan, B.; Portaliou, A. G.; Parakra, R.; Smit, J. H.; Wald, J.; Li, Y.; Srinivasu, B. Y.; Loos, M. S.; Dhupar, H. S.; Fahrenkamp, D.; Kalodimos, C. G.; Duong, F.; Cordes, T.; Karamanou, S.; Marlovits, T. C.; Economou, A.
10.1101/2020.11.20.391094 — molecular biology — Posted on 2021-06-14
2258 Estrogen Drives Melanocortin Neurons To Increase Spontaneous Activity and Reduce Sedentary Behavior
Krause, W. C.; Rodriguez, R.; Gegenhuber, J. B.; Matharu, N.; Rodriguez, A. N.; Padilla-Roger, A.; Toma, K.; Herber, C. B.; Correa, S. M.; Duan, X.; Ahituv, N. M.; Tollkuhn, J.; Ingraham, H. A.
10.1101/794792 — neuroscience — Posted on 2021-06-14
2259 Accurate viral genome reconstruction and host assignment with proximity-ligation sequencing
Uritskiy, G.; Press, M.; Sun, C.; Huerta, G. D.; Zayed, A. A.; Wiser, A.; Grove, J.; Auch, B.; Eacker, S. M.; Sullivan, S.; Bickhart, D. M.; Smith, T. P. L.; Sullivan, M. B.; Liachko, I.
10.1101/2021.06.14.448389 — genomics — Posted on 2021-06-14
2260 Negative modulation of macroautophagy by HERPUD1 is counteracted by an increased ER-lysosomal network with impact in drug-induced stress cell survival
Vargas, G.; Cortes, O. H.; Arias-Munoz, E. N.; Hernandez-Galaz, S. F.; Cerda-Troncoso, C.; Hernandez-Torres, L.; Gonzalez, A. E.; Tatham, M.; Bustamante, H. A.; Retamal, C. E.; Cancino, J.; Varas-Godoy, M.; Hay, R. T.; Rojas-Fernandez, A.; Cavieres, V. A.; Burgos, P. V.
10.1101/2021.06.14.447273 — cell biology — Posted on 2021-06-14
2265 A large disordered region confers a wide spanning volume to vertebrate Suppressor of Fused as shown in a trans-species solution study.
Makamte, S.; Jabrani, A.; Paquelin, A.; Plessis, A.; Sanial, M.; Thureau, A.; Roudenko, O.; Oteri, F.; Baaden, M.; Biou, V.
10.1101/2021.06.14.447554 — biophysics — Posted on 2021-06-14
2267 Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals
Jagoda, E.; Marnetto, D.; Montinaro, F.; Richard, D.; Pagani, L.; Capellini, T. D.
10.1101/2021.06.12.448149 — genetics — Posted on 2021-06-14
2268 COVID-eVax, an electroporated plasmid DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain, elicits protective immune responses in animal models of COVID-19
Conforti, A.; Marra, E.; Palombo, F.; Roscilli, G.; Rava, M.; Fumagalli, V.; Muzi, A.; Maffei, M.; Luberto, L.; Lione, L.; Salvatori, E.; Compagnone, M.; Pinto, E.; Pavoni, E.; Bucci, F.; Vitagliano, G.; Stoppoloni, D.; Pacello, M. L.; Cappelletti, M.; Ferrara, F. F.; D'Acunto, E.; Chiarini, V.; Arriga, R.; Nyska, A.; Di Lucia, P.; Marotta, D.; Bono, E.; Giustini, L.; Sala, E.; Perucchini, C.; Paterson, J.; Ryan, K. A.; Challis, A.; Matusali, G.; Colavita, F.; Caselli, G.; Criscuolo, E.; Clementi, N. A.; Mancini, N.; Gross, R.; Siedel, A.; Wettstein, L.; Munch, J.; Donnici, L.; Conti, M.; De F
10.1101/2021.06.14.448343 — immunology — Posted on 2021-06-14
2269 Preterm birth is associated with xenobiotics and predicted by the vaginal metabolome
Kindschuh, W. F.; Baldini, F.; Liu, M. C.; Gerson, K. D.; Liao, J.; Lee, H. H.; Anton, L.; Gajer, P.; Ravel, J.; Levy, M.; Elovitz, M.; Korem, T.
10.1101/2021.06.14.448190 — systems biology — Posted on 2021-06-14
2270 Altered DNA methylation in ion transport and immune signalling genes is associated with severity in Pancreatic Ductal Adenocarcinoma
Chatterjee, A.; Bararia, A.; Ganguly, D.; Roy, P.; Banerjee, S.; Ghosh, S.; Gulati, S.; Ghatak, S.; Chatterjee, B. K.; Maitra, A.; Basu, P.; Chatterjee, A.; Sikdar, N.
10.1101/2021.06.14.448193 — cancer biology — Posted on 2021-06-14
2273 CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2
Amraei, R.; Napoleon, M.; Yin, W.; Berrigan, J.; Suder, E.; Zhao, G.; Olejnik, J.; Chandler, K.; Xia, C.; Gummuluru, S.; Muhlberger, E.; Chitalia, V.; Costello, C.; Rahimi, N.
10.1101/2020.06.22.165803 — cell biology — Posted on 2021-06-14
2274 A high-throughput multiplexing and selection strategy to complete bacterial genomes
Arredondo-Alonso, S.; Pöntinen, A. K.; Cleon, F.; Gladstone, R. A.; Schürch, A. C.; Johnsen, P. J.; Samuelsen, O.; Corander, J.
10.1101/2021.06.14.448320 — microbiology — Posted on 2021-06-14
2275 Microbial metabolism and adaptations in Atribacteria-dominated methane hydrate sediments
Glass, J. B.; Ranjan, P.; Kretz, C. B.; Nunn, B. L.; Johnson, A. M.; Xu, M.; McManus, J.; Stewart, F. J.
10.1101/536078 — microbiology — Posted on 2021-06-14
2276 Serotonergic neurons mediate operant conditioning in Drosophila larvae
Klein, K. T.; Croteau-Chonka, E. C.; Narayan, L.; Winding, M.; Masson, J.-B.; Zlatic, M.
10.1101/2021.06.14.448341 — neuroscience — Posted on 2021-06-14
2277 EEG-based visual deviance detection in freely behaving mice
Kat, R.; van den Berg, B.; Perenboom, M. J. L.; Schenke, M.; van den Maagdenberg, A. M. J. M.; Bruining, H.; Tolner, E. A.; Kas, M. J. H.
10.1101/2021.06.14.448331 — neuroscience — Posted on 2021-06-14
2280 Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance
Dorel, M.; Klinger, B.; Mari, T.; Toedling, J.; Blanc, E.; Nadler-Holly, M.; Ziehm, M.; Sieber, A.; Hertwig, F.; Beule, D.; Eggert, A.; Schulte, J. H.; Selbach, M.; Bluthgen, N.
10.1101/2021.06.14.448322 — cancer biology — Posted on 2021-06-14
2282 Epigenetic features improve TALE target prediction
Erkes, A.; Mücke, S.; Reschke, M.; Boch, J.; Grau, J.
10.1101/2021.06.14.448323 — bioinformatics — Posted on 2021-06-14
2284 Evolution of the open-access CIViC knowledgebase is driven by the needsof the cancer variant interpretation community
Krysiak, K.; Danos, A. M.; Kiwala, S.; McMichael, J. F.; Coffman, A. C.; Barnell, E. K.; Sheta, L.; Saliba, J.; Grisdale, C. J.; Kujan, L.; Pema, S.; Lever, J.; Spies, N. C.; Chiorean, A.; Rieke, D. T.; Clark, K. A.; Jani, P.; Takahashi, H.; Horak, P.; Ritter, D. I.; Zhou, X.; Ainscough, B. J.; Delong, S.; Lamping, M.; Marr, A. R.; Li, B. V.; Lin, W.-H.; Terraf, P.; Salama, Y.; Campbell, K.; Farncombe, K. M.; Ji, J.; Zhao, X.; Xu, X.; Kanagal-Shamanna, R.; Cotto, K.; Skidmore, Z. L.; Walker, J. R.; Zhang, J.; Milosavljevic, A.; Patel, R. Y.; Giles, R. H.; Kim, R. H.; Schriml, L. M.; Mardis, E.
10.1101/2021.06.13.448171 — genomics — Posted on 2021-06-14
2289 Bacteriophage T4 Vaccine Platform for Next-generation Influenza Vaccine Development
Li, M.; Guo, P.; Chen, C.; Feng, H.; Zhang, W.; Gu, C.; Wen, G.; Rao, V. B.; Tao, P.
10.1101/2021.06.14.448336 — microbiology — Posted on 2021-06-14
2294 Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential
Meyer, B.; Chiaravalli, J.; Gellenoncourt, S.; Brownridge, P.; Bryne, D. P.; Daly, L. A.; Grauslys, A.; Walter, M.; Agou, F.; Chakrabarti, L. A.; Craik, C. S.; Eyers, C. E.; Eyers, P. A.; Gambin, Y.; Jones, A. R.; Sierecki, E.; Verdin, E.; Vignuzzi, M.; Emmott, E.
10.1101/2020.09.16.297945 — microbiology — Posted on 2021-06-14
2302 Quantifying concordant genetic effects of de novo mutations on multiple disorders
Guo, H.; Hou, L.; Shi, Y.; Jin, S. C.; Zeng, X.; Li, B.; Lifton, R.; Brueckner, M.; Zhao, H.-y.; Lu, Q.
10.1101/2021.06.13.448234 — genetics — Posted on 2021-06-14
2303 A comprehensive series of temporal transcription factors in the fly visual system
Konstantinides, N.; Rossi, A. M.; Escobar, A.; Dudragne, L.; Chen, Y.-C.; Tran, T.; Jaimes, A. M.; Ozel, M. N.; Simon, F.; Shao, Z.; Tsankova, N. M.; Fullard, J. F.; Walldorf, U.; Roussos, P.; Desplan, C.
10.1101/2021.06.13.448242 — developmental biology — Posted on 2021-06-14
2304 TDAExplore: quantitative image analysis through topology-based machine learning
Edwards, P.; Skruber, K.; Milicevic, N.; Heidings, J. B.; Read, T.-A.; Bubenik, P.; Vitriol, E.
10.1101/2021.06.13.448249 — cell biology — Posted on 2021-06-14
2305 Plastic cell morphology changes during dispersal
Junker, A. D.; Jacob, S.; Philippe, H.; Legrand, D.; Pearson, C. G.
10.1101/2021.06.13.448130 — cell biology — Posted on 2021-06-14
2310 The Genetic Architecture of Strawberry Yield and Fruit Quality Traits
Cockerton, H. M.; Karlstrom, A.; Johnson, A.; Li, B. M.; Stavridou, E.; Hopson, K.; Whitehouse, A.; Harrison, R. J.
10.1101/2021.06.13.448230 — plant biology — Posted on 2021-06-14
2311 Mechanosensory trichome cells evoke a mechanical stimuli-induced immune response in plants
Matsumura, M.; Nomoto, M.; Itaya, T.; Aratani, Y.; Iwamoto, M.; Matsuura, T.; Mori, I.; Hayashi, Y.; Kinoshita, T.; Suzuki, T.; Betsuyaku, S.; Spoel, S. H.; Toyota, M.; Tada, Y.
10.1101/2021.06.13.448005 — plant biology — Posted on 2021-06-14
2313 Emerging Hantaviruses in Central Argentina: first case of Hantavirus Pulmonary Syndrome caused by Alto Paraguay Virus and a novel orthohantavirus in Scapteromys aquaticus rodent.
Bellomo, C. M.; Alonso, D.; Ricardo, T.; Coelho, R.; Kehl, S.; Periolo, N.; Casas, N.; Bergero, L. C.; Previtali, M. A.; Martinez, V. P.
10.1101/2021.06.13.448262 — pathology — Posted on 2021-06-14
2314 Counterdiabatic control of biophysical processes
Ilker, E.; Güngör, O.; Kuznets-Speck, B.; Chiel, J.; Deffner, S.; Hinczewski, M.
10.1101/2021.06.13.448255 — biophysics — Posted on 2021-06-14
2318 Brain network dynamics codify heterogeneity in seizure propagation
Rungratsameetaweemana, N.; Lainscsek, C.; Cash, S. S.; Garcia, J. O.; Sejnowski, T. J.; Bansal, K.
10.1101/2021.06.12.448205 — neuroscience — Posted on 2021-06-14
2323 Specific and dynamic lignification at the cell-type level controls plant physiology and adaptability
Menard, D.; Blaschek, L.; Kriechbaum, K.; Lee, C. C.; Zhu, C.; Nuoendagula, ; Bacsik, Z.; Bergström, L.; Mathew, A.; Kajita, S.; Pesquet, E.
10.1101/2021.06.12.447240 — plant biology — Posted on 2021-06-14
2325 Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: a pan-cancer systematic review and meta-analysis of preclinical models
Websdale, A.; Kiew, Y.; Chalmers, P.; Chen, X.; Cioccoloni, G.; Hughes, T. A.; Luo, X.; Mwarazi, R.; Poirot, M.; Roberg-Larsen, H.; Wu, R.; Xu, M.; Zulyniak, M. A.; Thorne, J. L.
10.1101/2021.06.12.448188 — cancer biology — Posted on 2021-06-14
2329 Effectiveness of antifungal treatments during chytridiomycosis epizootics in populations of an endangered frog
Knapp, R. A.; Joseph, M. B.; Smith, T. C.; Hegeman, E. E.; Vredenburg, V. T.; Erdman, J. E.; Boiano, D. M.; Jani, A. J.; Briggs, C. J.
10.1101/2021.06.13.448228 — ecology — Posted on 2021-06-14
2331 Plasmodium falciparum protein Pfs16 is a target for transmission-blocking antimalarial drug development
Yahiya, S.; Saunders, C. N.; Straschil, U.; Fischer, O. J.; Rueda-Zubiaurre, A.; Haase, S.; Vizcay-Barrena, G.; Jordan, S.; Hassan, S.; Delves, M. J.; Tate, E. W.; Barnard, A.; Fuchter, M. J.; Baum, J.
10.1101/2021.06.14.448287 — microbiology — Posted on 2021-06-14
2332 Truly Privacy-Preserving Federated Analytics for Precision Medicine with Multiparty Homomorphic Encryption
Froelicher, D.; Troncoso-pastoriza, J. R.; Raisaro, J. L.; Cuendet, M.; Sa Sousa, J.; Cho, H.; Berger, B.; Fellay, J.; Hubaux, J.-P.
10.1101/2021.02.24.432489 — bioinformatics — Posted on 2021-06-14
2333 Colonial choanoflagellate isolated from Mono Lake harbors a microbiome
Hake, K.; West, P. T.; McDonald, K. L.; Laundon, D.; Garcia De Las Bayonas, A.; Feng, C.; Burkhardt, P.; Richter, D. J.; Banfield, J.; King, N.
10.1101/2021.03.30.437421 — microbiology — Posted on 2021-06-14
2336 INDEHISCENT regulates explosive seed dispersal
Galstyan, A.; Sarchet, P.; Campos-Martin, R.; Adibi, M.; Nikolov, L. A.; Perez Anton, M.; Rambaud-Lavigne, L.; Gan, X.; Hay, A.
10.1101/2021.06.11.448014 — plant biology — Posted on 2021-06-14
2337 Differential contributions of M1 and pre-M1 to ion selectivity in ASICs and ENaCs
Sheikh, Z. P.; Wulf, M.; Friis, S.; Althaus, M.; Lynagh, T.; Pless, S. A.
10.1101/2021.02.16.431267 — biophysics — Posted on 2021-06-14
2339 Schizophrenia polygenic risk during typical development reflects multiscale cortical organization
Kirschner, M.; Paquola, C.; Khundrakpam, B.; Vainik, U.; Bhutani, N.; Hodzic-Santor, B.; Al-Sharif, N. B.; Misic, B.; Bernhardt, B.; Evans, A. C.; Dagher, A.
10.1101/2021.06.13.448243 — neuroscience — Posted on 2021-06-13
2340 Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics
Koessinger, A.; Koessinger, D.; Kinch, K.; Martinez-Escardo, L.; Paul, N.; Elmasry, Y.; Malviya, G.; Cloix, C.; Campbell, K.; Bock, F.; O'Prey, J.; Stevenson, K.; Nixon, C.; Jackson, M.; Ichim, G.; Stewart, W.; Blyth, K.; Ryan, K.; Chalmers, A. J.; Norman, J.; Tait, S.
10.1101/2021.06.13.448232 — cancer biology — Posted on 2021-06-13
2341 Reproducibility of protein X-ray diffuse scattering and potential utility for modeling atomic displacement parameters
Su, Z.; Dasgupta, M.; Poitevin, F.; Mathews, I. I.; van den Bedem, H.; Wall, M. E.; Yoon, C. H.; Wilson, M. A.
10.1101/2021.01.24.428002 — biophysics — Posted on 2021-06-13
2343 Viral manipulation of mechanoresponsive signaling disassembles processing bodies
Castle, E. L.; Robinson, C.-A.; Douglas, P.; Rinker, K. D.; Corcoran, J. A.
10.1101/2020.05.15.091876 — cell biology — Posted on 2021-06-13
2346 Multimodal Single-Cell Characterization of the Human Granulocyte Lineage
Qi, J.; D'Souza, D.; Dawson, T.; Geanon, D.; Stefanos, H.; Marvin, R.; Walker, L.; Rahman, A. H.
10.1101/2021.06.12.448210 — immunology — Posted on 2021-06-13
2348 Radiosynthesis and preclinical evaluation of a carbon-11 labeled PDE7 inhibitor for PET neuroimaging
Xiao, Z.; Sun, J.; Fujinaga, M.; Wei, H.; Zhao, C.; Haider, A.; Van, R.; Yamasaki, T.; Zhang, Y.; Rong, J.; Hu, K.; Chen, J.; Leon, E. C.; Hiraishi, A.; Wei, J.; Xu, Y.; Shao, Y.; Zhang, H.-T.; Lloyd, K. C. K.; Wang, L.; Zhang, M.-R.; Liang, S. H.
10.1101/2021.06.12.447900 — neuroscience — Posted on 2021-06-13
2352 Covering soybean leaves with cellulose nanofiber changes leaf surface hydrophobicity and confers resistance against Phakopsora pachyrhizi
Saito, H.; Yamashita, Y.; Sakata, N.; Ishiga, T.; Shiraishi, N.; Usuki, G.; Nguyen, V. T.; Yamamura, E.; Ishiga, Y.
10.1101/2020.08.26.267807 — plant biology — Posted on 2021-06-13
2354 TMEM120 is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase
Xue, J.; Han, Y.; Baniasadi, H.; Zeng, W.; Pei, J.; Grishin, N.; Wang, J.; Tu, B. P.; Jiang, Y.
10.1101/2021.06.13.448233 — biophysics — Posted on 2021-06-13
2356 Workflows for rapid functional annotation of diverse arthropod genomes
Saha, S.; Cooksey, A. M.; Childers, A. K.; Poelchau, M.; McCarthy, F.
10.1101/2021.06.12.448177 — bioinformatics — Posted on 2021-06-13
2359 Captivity-induced behaviour and spatial learning abilities in an enigmatic, aquifer-dwelling blind eel, Rakthamichthys digressus
Vasan, T.; Das, P.; Varma, V.; Tiwari, A.; Prakash, A.; Manilal, D.; Thomas, L.; Arjun, C. P.; Philip, S.; Raghavan, R.; Binoy, V. V.
10.1101/2021.06.12.448170 — animal behavior and cognition — Posted on 2021-06-13
2361 The activity and functions of subarctic soil microbial communities vary across vegetation types
Viitamaki, S.; Pessi, I. S.; Virkkala, A.-M.; Niittynen, P.; Kemppinen, J.; Eronen-Rasimus, E.; Luoto, M.; Hultman, J.
10.1101/2021.06.12.448001 — microbiology — Posted on 2021-06-13
2363 A Framework for Brain Atlases: Lessons from seizure Dynamics
Revell, A. Y.; Silva, A. B.; Arnold, T. C.; Stein, J. M.; Das, S. R.; Shinohara, R. T.; Bassett, D. S.; Litt, B.; Davis, K. A.
10.1101/2021.06.11.448063 — neuroscience — Posted on 2021-06-13
2369 Supervised learning with word embeddings derived from PubMed captures latent knowledge about protein kinases and cancer
Ravanmehr, V.; Blau, H.; Cappelletti, L.; Fontana, T.; Carmody, L.; Coleman, B.; George, J.; Reese, J.; Joachimiak, M.; Bocci, G.; Bult, C. J.; Rueter, J.; Casiraghi, E.; Valentini, G.; Mungall, C. J.; Oprea, T. I.; Robinson, P. N.
10.1101/2021.06.11.447943 — bioinformatics — Posted on 2021-06-13
2370 A TPR scaffold couples signal detection to OdhI phosphorylation in metabolic control by the protein kinase PknG
Lisa, M. N.; Sogues, A.; Barilone, N.; Baumgart, M.; Gil, M.; Grana, M.; Duran, R.; Biondi, R. M.; Bellinzoni, M.; Bott, M.; Alzari, P. M.
10.1101/2021.06.11.448168 — biochemistry — Posted on 2021-06-13
2375 Newly synthesized RNA Sequencing Characterizes Transcription Dynamics in Three Pluripotent States
Shao, R.; Kumar, B.; Liedschreiber, K.; Lidschreiber, M. M.; Cramer, P.; Elsässer, S. J.
10.1101/2021.06.11.448016 — systems biology — Posted on 2021-06-13
2376 Anti-SARS-CoV-2 potential of Cissampelos pareira L. identified by Connectivity map-based analysis and in vitro studies
Haider, M.; Anand, V.; Dholakia, D.; Enayathullah, M. G.; Parekh, Y.; Ram, S.; Kumari, S.; K, A.; Bokara, K. K.; Sharma, U.; Prasher, B.; Mukerji, M.
10.1101/2021.06.11.448155 — systems biology — Posted on 2021-06-13
2377 Metabolomic analysis of diverse mice reveals hepatic arginase-1 as source of plasma arginase in Plasmodium chabaudi infection
Davis, N. M.; Lissner, M. M.; Massis, L. M.; Richards, C. L.; Chevee, V.; Gupta, A. S.; Gherardini, F. C.; Monack, D. M.; Schneider, D. S.
10.1101/2021.06.11.448167 — pathology — Posted on 2021-06-13
2378 Encapsulated allografts preclude host sensitization and promote ovarian endocrine function in ovariectomized young rhesus monkeys and sensitized mice
Day, J. R.; Flanagan, C. L.; David, A.; Hartigan-O'Connor, D. J.; de Mattos Barbosa, M. G.; Martinez, M. L.; Lee, C.; Barnes, J.; Farkash, E.; Zelinski, M.; Tarantal, A.; Cascalho, M.; Shikanov, A.
10.1101/2021.06.10.447598 — bioengineering — Posted on 2021-06-13
2380 UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates
Rosenke, K.; Feldmann, F.; Okumura, A.; Hansen, F.; Tang-Huau, T.-L.; Meade-White, K.; Kaza, B.; Smith, B. J.; Hanley, P. W.; Lovaglio, J.; Jarvis, M.; Shaia, C.; Feldmann, H.
10.1101/2021.06.11.448134 — microbiology — Posted on 2021-06-13
2381 Improved SNV discovery in barcode-stratified scRNA-seq alignments
Prashant, N.; Liu, H.; Dillard, C.; Ibeawuchi, H.; Alsaeedy, T.; Chan, K. H.; Horvath, A.
10.1101/2021.06.12.448184 — genomics — Posted on 2021-06-13
2383 Ultrasound mediated cellular deflection results in cellular depolarization
Vasan, A.; Orosco, J.; Magaram, U.; Weiss, C.; Duque, M.; Tufail, Y.; Chalasani, S. H.; Friend, J.
10.1101/2021.06.11.447976 — bioengineering — Posted on 2021-06-13
2384 Mobile antimicrobial resistance genes in probiotics
Toth, A. G.; Csabai, I.; Judge, M. F.; Maroti, G.; Becsei, A.; Spisak, S.; Solymosi, N.
10.1101/2021.05.04.442546 — genomics — Posted on 2021-06-13
2387 TRAF2, an innate immune sensor, reciprocally regulates mitophagy and inflammation to maintain cardiac myocyte homeostasis.
Ma, X.; Rawnsley, D. R.; Kovacs, A.; Islam, M.; Murphy, J. T.; Zhao, C.; Kumari, M.; Foroughi, L. M.; Liu, H.; Hyrc, K.; Evans, S.; French, B. A.; Margulies, K. B.; Javaheri, A.; Razani, B.; Mann, D. L.; Mani, K.; Diwan, A.
10.1101/2021.06.12.448118 — cell biology — Posted on 2021-06-13
2390 Probing individual-level structural atrophy in frontal glioma patients
Zhang, G.; Huang, H.; Zhang, X.; Wang, Y.; Li, H.; Duan, Y.; Chen, H.; Liu, Y.; Jing, B.; Lin, S.
10.1101/2021.01.30.428923 — neuroscience — Posted on 2021-06-13
2393 SlKIX8 and SlKIX9 are negative regulators of leaf and fruit growth in tomato
Swinnen, G.; Mauxion, J.-P.; Baekelandt, A.; De Clercq, R.; Van Doorsselaere, J.; Inze, D.; Gonzalez, N.; Goossens, A.; Pauwels, L.
10.1101/2020.02.07.938977 — plant biology — Posted on 2021-06-13
2394 Evidence for two distinct thalamocortical circuits in retrosplenial cortex
Lomi, E.; Mathiasen, M. L.; Cheng, H. Y.; Zhang, N.; Aggleton, J. P.; Mitchell, A. S.; Jeffery, K. J.
10.1101/2021.06.11.448056 — neuroscience — Posted on 2021-06-13
2395 Expression Based Species Deconvolution and Realignment Removes Misalignent Error in Multi-species Single Cell Data
Choi, J.; Lee, W.; Yoon, J.-k.; Choi, S. M.; Lee, C.-H.; Moon, H.-G.; Cho, S.; Chung, J.-H.; Yang, H.-K.; Kim, J.-i.
10.1101/2021.04.04.438147 — bioinformatics — Posted on 2021-06-13
2398 Evidence for two distinct thalamocortical circuits in retrosplenial cortex
Lomi, E.; Mathiasen, M. L.; Cheng, H. Y.; Zhang, N.; Aggleton, J. P.; Mitchell, A. S.; Jeffery, K. J.
10.1101/2021.06.11.448056 — neuroscience — Posted on 2021-06-12
2399 Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways
Schaffner, S. L.; Wassouf, Z.; Lazaro, D.; Xylaki, M.; Gladish, N.; Lin, D. T. S.; MacIsaac, J.; Ramadori, K.; Schulze-Hentrich, J. M.; Outeiro, T. F.; Kobor, M. S.
10.1101/2021.06.12.448150 — genomics — Posted on 2021-06-12
2400 Oxaliplatin kills cells via liquid-liquid demixing of nucleoli
Schmidt, H. B.; Jaafar, Z. A.; Rodencal, J. J.; Leonetti, M. D.; Dixon, S. J.; Rohatgi, R.; Brandman, O.
10.1101/2021.06.10.447918 — cell biology — Posted on 2021-06-12
2403 High-fidelity fast volumetric brain MRI using synergistic wave-controlled aliasing in parallel imaging and a hybrid denoising generative adversarial network
Li, Z.; Tian, Q.; Ngamsombat, C.; Cartmell, S.; Conklin, J.; Filho, A. L. M. G.; Lo, W.-C.; Wang, G.; Ying, K.; Setsompop, K.; Fan, Q.; Bilgic, B.; Cauley, S.; Huang, S.
10.1101/2021.01.07.425779 — neuroscience — Posted on 2021-06-12
2404 SCReadCounts: Estimation of cell-level SNVs from scRNA-seq data
Prashant, N.; Alomran, N.; Chen, Y.; Liu, H.; Bousounis, P.; Movassagh, M.; Edwards, N. J.; Horvath, A.
10.1101/2020.11.23.394569 — bioinformatics — Posted on 2021-06-12
2405 Minimal information for Chemosensitivity assays (MICHA): A next-generation pipeline to enable the FAIRification of drug screening experiments
Tanoli, Z.; Aldahdooh, J.; Alam, F.; Wang, Y.; Seemab, U.; Fratelli, M.; Pavlis, P.; Hajduch, M.; Bietrix, F.; Gribbon, P.; Zaliani, A.; Hall, M. D.; Shen, M.; Brimacombe, K.; Kulesskiy, E.; Saarela, J.; Wennerberg, K.; Vaha-Koskela, M.; Tang, J.
10.1101/2020.12.03.409409 — bioinformatics — Posted on 2021-06-12
2408 A non-canonical lipid droplet metabolism regulates the conversion of alpha-Synuclein to proteolytic resistant forms in neurons of a Drosophila model of Parkinson disease
Girard, V.; Jollivet, F.; Knittelfelder, O.; Arsac, J.-N.; Chatelain, G.; Van den Brink, D.; Baron, T.; Shevchenko, A.; Davoust-Nataf, N.; Mollereau, B.
10.1101/2020.09.16.299354 — cell biology — Posted on 2021-06-12
2410 Repertoire of naturally acquired maternal antibodies transferred to infants for protection against shigellosis
Ndungo, E.; Andronescu, L. R.; Buchwald, A. G.; Mawindo, P.; Kapoor, N.; Fairman, J.; Laufer, M. K.; Pasetti, M. F.
10.1101/2021.05.21.445178 — immunology — Posted on 2021-06-12
2415 CODEC enables 'single duplex' sequencing
Bae, J. H.; Liu, R.; Nguyen, E.; Rhoades, J.; Blewett, T.; Xiong, K.; Shea, D.; Gydush, G.; Tabrizi, S.; An, Z.; Patel, S.; Makrigiorgos, G. M.; Golub, T. R.; Adalsteinsson, V. A.
10.1101/2021.06.11.448110 — bioengineering — Posted on 2021-06-12
2416 SpotClean adjusts for spot swapping in spatial transcriptomics data
Ni, Z.; Prasad, A.; Chen, S.; Halberg, R. B.; Arkin, L.; Drolet, B.; Newton, M.; Kendziorski, C.
10.1101/2021.06.11.448105 — genomics — Posted on 2021-06-12
2418 Comparative therapeutic strategies for preventing aortic rupture in a mouse model of vascular Ehlers Danlos syndrome
Legrand, A.; Guery, C.; Faugeroux, J.; Fontaine, E.; Gianfermi, A.; Ferreira, I.; Verpont, M.-c.; Adham, S.; Mirault, T.; Hadchouel, J.; Jeunemaitre, X.
10.1101/2021.06.12.448202 — genetics — Posted on 2021-06-12
2419 The origin of asexual brine shrimps
Rode, N. O.; Jabbour-Zahab, R.; Boyer, L.; Flaven, E.; Hontoria, F.; Van Stappen, G.; Dufresne, F.; Haag, C. R.; Lenormand, T.
10.1101/2021.06.11.448048 — evolutionary biology — Posted on 2021-06-12
2420 Ageing red deer alter their spatial behaviour and become less social
Albery, G. F.; Clutton-Brock, T. H.; Morris, A.; Morris, S.; Pemberton, J. M.; Nussey, D. H.; Firth, J. A.
10.1101/2021.06.11.448092 — ecology — Posted on 2021-06-12
2421 Determinants of haemosporidian single and co-infections risks in western paleartic birds
Pigeault, R.; Chevalier, M.; Cozzarolo, C.-s.; Baur, M.; Arlettaz, M.; Cibois, A.; Keiser, A.; Guisan, A.; Christe, P.; Glaizot, O.
10.1101/2021.06.11.448006 — ecology — Posted on 2021-06-12
2423 Cysteine dependence in Lactobacillus iners constitutes a novel therapeutic target to modify the vaginal microbiota
Bloom, S. M.; Mafunda, N. A.; Woolston, B. M.; Hayward, M. R.; Frempong, J. F.; Abai, A. B.; Xu, J.; Mitchell, A. J.; Westergaard, X.; Hussain, F. A.; Xulu, N.; Dong, M.; Dong, K. L.; Gumbi, T.; Ceasar, X.; Rice, J. K.; Choksi, N.; Ismail, N.; Ndung'u, T.; Ghebremichael, M. S.; Balskus, E. P.; Mitchell, C. M.; Kwon, D. S.
10.1101/2021.06.12.448098 — microbiology — Posted on 2021-06-12
2427 Stratum Lacunosum-moleculare Interneurons of the Hippocampus Coordinate Memory Encoding and Retrieval
Guo, J.; Oliveros, H. C.; Oh, S. J.; Liang, B.; Li, Y.; Kavalali, E. T.; Lin, D.-T.; Xu, W.
10.1101/2021.06.11.448103 — neuroscience — Posted on 2021-06-12
2428 Polysaccharide utilization loci in Bacteroides determine population fitness and community-level interactions
Feng, J.; Qian, Y.; Zhou, Z.; Ertmer, S.; Vivas, E.; Lan, F.; Rey, F. E.; Anantharaman, K.; Venturelli, O. S.
10.1101/2021.06.12.448201 — synthetic biology — Posted on 2021-06-12
2432 Enviromic-based Kernels Optimize Resource Allocation with Multi-trait Multi-environment Genomic Prediction for Tropical Maize
Gevartosky, R.; Carvalho, H. F.; Costa-Neto, G.; Montesinos-Lopez, O. A.; Crossa, J.; Fritsche-Neto, R.
10.1101/2021.06.11.448049 — genetics — Posted on 2021-06-12
2433 CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects IRF8 expression through cooperative lncRNA and DNA methylation machinery
Zhou, T.; Zhu, X.; Ye, Z.; Wang, Y.; Yao, C.; Xu, N.; Zhou, M.; Ma, J.; Qin, Y.; Shen, Y.; Tang, Y.; Yin, Z.; Xu, H.; Zhang, Y.; Zang, X.; Ding, H.; Yang, W.; Guo, Y.; Harley, J. B.; Namjou, B.; Kaufman, K. M.; Kottyan, L. C.; Weirauch, M. T.; Hou, G.; Shen, N.
10.1101/2021.06.11.448156 — genetics — Posted on 2021-06-12
2434 Photosynthesis from stolen chloroplasts increases sea slug reproductive fitness
Cartaxana, P.; Rey, F.; Lekieffre, C.; Lopes, D.; Hubas, C.; Spangenberg, J.; Escrig, S.; Jesus, B.; Calado, G.; Domingues, R.; Kuhl, M.; Calado, R.; Meibom, A.; Cruz, S.
10.1101/2021.06.11.448027 — ecology — Posted on 2021-06-12
2435 A secondary metabolite drives intraspecies antagonism in a gut symbiont that is inhibited by peptidoglycan acetylation
Özcam, M.; Oh, J.-H.; Tocmo, R.; Acharya, D.; Zhang, S.; Ruiz-Ramirez, S.; Li, F.; Cheng, C. C.; Vivas, E.; Rey, F. E.; Claesen, J.; Bugni, T.; Walter, J.; van Pijkeren, J. P.
10.1101/2021.06.11.448121 — microbiology — Posted on 2021-06-12
2436 Sustained replication of synthetic canine distemper virus defective genomes in vitro and in vivo
Tilston-Lunel, N.; Welch, S. R.; Nambulli, S.; de Vries, R. D.; Ho, G.; Wentworth, D.; Shabman, R. S.; Nichol, S. T.; Spiropoulou, C. F.; de Swart, R. L.; Rennick, L. J.; Duprex, W. P.
10.1101/2021.06.11.448162 — microbiology — Posted on 2021-06-12
2439 Analysis of the Mechanosensor Channel Functionality of TACAN
Niu, Y.; Tao, X.; Vaisey, G.; Olinares, P. D. B.; Alwaseem, H.; Chait, B.; MacKinnon, R.
10.1101/2021.06.11.448078 — biophysics — Posted on 2021-06-12
2443 Structural Basis for Cytoplasmic Dynein-1 Regulation by Lis1
Gillies, J. P.; Reimer, J. M.; Karasmanis, E. P.; Lahiri, I.; Htet, Z. M.; Leschziner, A. E.; Reck-Peterson, S. L.
10.1101/2021.06.11.448119 — cell biology — Posted on 2021-06-11
2445 Cooperation of two opposite flagella allows high-speed swimming and active turning in zoospores
Tran, Q. D.; Galiana, E.; Thomen, P.; Cohen, C.; Orange, F.; Peruani, F.; Noblin, X.
10.1101/2021.04.23.441092 — biophysics — Posted on 2021-06-11
2446 Cryo-EM structure of native human thyroglobulin
Adaixo, R.; Steiner, E. M.; Righetto, R. D.; Schmidt, A.; Stahlberg, H.; Taylor, N. M. I.
10.1101/2021.06.06.447243 — biophysics — Posted on 2021-06-11
2447 Illuminating the transposon insertion landscape in plants using Cas9-targeted Nanopore sequencing and a novel pipeline
Kirov, I.; Merkulov, P.; Gvaramiya, S.; Komakhin, R.; Omarov, M.; Dudnikov, M.; Kocheshkova, A.; Soloviev, A.; Karlov, G.; Divashuk, M.
10.1101/2021.06.11.448052 — genomics — Posted on 2021-06-11
2448 Selective sweeps influence diversity over large regions of the mouse genome
Booker, T. R.; Jackson, B. C.; Craig, R. J.; Charlesworth, B.; Keightley, P. D.
10.1101/2021.06.10.447924 — evolutionary biology — Posted on 2021-06-11
2451 Interferon-α subtype treatment induces the repression of SRSF1 in HIV-1 target cells and affects HIV-1 post integration steps
Sertznig, H.; Roesmann, F.; Bleekmann, B.; Elsner, C.; Santiago, M. L.; Schuhenn, J.; Benatzy, Y.; Snodgrass, R.; Esser, S.; Sutter, K.; Dittmer, U.; Widera, M.
10.1101/2021.06.11.448031 — microbiology — Posted on 2021-06-11
2452 Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Proteinco-immunization in rhesus macaques
Rosati, M.; Agarwal, M.; Hu, X.; Devasundaram, S.; Stellas, D.; Chowdhury, B.; Bear, J.; Burns, R.; Donohue, D.; Pessaint, L.; Andersen, H.; Lewis, M. G.; Terpos, E.; Dimopoulos, M. A.; Wlodawer, A.; Mullins, J. I.; Venzon, D. J.; Pavlakis, G. N.; Felber, B. K.
10.1101/2021.06.11.448032 — immunology — Posted on 2021-06-11
2454 A quantitative gibberellin signalling biosensor reveals a role for gibberellins in internode specification at the shoot apical meristem
Shi, B.; Felipo-Benavent, A.; Cerutti, G.; Galvan-Ampudia, C.; Jilli, L.; Brunoud, G.; Mutterer, J.; Sakvarelidze-Achard, L.; Daviere, J.-M.; Navarro-Galiano, A.; Walia, A.; Lazary, S.; Legrand, J.; Weinstain, R.; Jones, A. M.; Prat, S.; Achard, P.; VERNOUX, T.
10.1101/2021.06.11.448154 — plant biology — Posted on 2021-06-11
2455 p53 mutations exhibit sex specific gain-of-function activity in gliomagenesis
Rockwell, N. C.; Yang, W.; Warrington, N.; Griffith, M.; Griffith, O. L.; Gurnett, C.; Cohen, B.; Baldridge, D.; Rubin, J. B.
10.1101/2021.06.11.448124 — cancer biology — Posted on 2021-06-11
2456 Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers
Lange, J. T.; Chen, C. Y.; Pichugin, Y.; Xie, F.; Tang, J.; Hung, K. L.; Yost, K. E.; Shi, Q.; Erb, M. L.; Rajkumar, U.; Wu, S.; Swanton, C.; Liu, Z.; Huang, W.; Chang, H. Y.; Bafna, V.; Henssen, A. G.; Werner, B.; Mischel, P. S.
10.1101/2021.06.11.447968 — cancer biology — Posted on 2021-06-11
2459 Structure of ABCB1/P-glycoprotein bound to the CFTR potentiator ivacaftor.
Barbieri, A.; Thonghin, N.; Shafi, T.; Prince, S. M.; Collins, R. F.; Ford, R. C.
10.1101/2021.06.11.448073 — biochemistry — Posted on 2021-06-11
2461 The central nucleus of the amygdala and gustatory cortex assess affective valence during CTA learning and expression in male and female rats
Bernanke, A.; Burnette, E.; Murphy, J.; Hernandez, N.; Zimmerman, S.; Walker, Q. D.; Wander, R.; Sette, S.; Reavis, Z.; Francis, R.; Armstrong, C.; Risher, M.-L.; Kuhn, C.
10.1101/2021.05.04.442519 — animal behavior and cognition — Posted on 2021-06-11
2469 Mapping microglia and astrocytes activation in vivo using diffusion MRI
Garcia-Hernandez, R.; Cerda, A. C.; Trouve Carpena, A.; Drakesmith, M.; Koller, K.; Jones, D. K.; Canals, S.; De Santis, S.
10.1101/2020.02.07.938910 — neuroscience — Posted on 2021-06-11
2471 Oncomodulin Delays Age-Related Hearing Loss in C57 and CBA Mice
Climer, L. K.; Hornak, A. J.; Murtha, K.; Yang, Y.; Cox, A. M.; Simpson, P. L.; Le, A.; Simmons, D. D.
10.1101/2021.06.11.448116 — neuroscience — Posted on 2021-06-11
2472 Population-level variation of enhancer expression identifies novel disease mechanisms in the human brain
Dong, P.; Hoffman, G. E.; Apontes, P.; Bendl, J.; Rahman, S.; Fernando, M. B.; Zeng, B.; Vicari, J. M.; Zhang, W.; Girdhar, K.; Townsley, K. G.; Misir, R.; the CommonMind Consortium, ; Brennand, K. J.; Haroutunian, V.; Voloudakis, G.; Fullard, J. F.; Roussos, P.
10.1101/2021.05.14.443421 — neuroscience — Posted on 2021-06-11
2473 Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex.
Lau, B. K.; Murphy-Royal, C.; Kaur, M.; Qiao, M.; Bains, J. S.; Gordon, G. R.; Borgland, S. L.
10.1101/2020.05.01.073205 — neuroscience — Posted on 2021-06-11
2474 Reduced Hippocampal Inhibition and Enhanced Autism-Epilepsy Comorbidity in Mice Lacking Neuropilin 2
Eisenberg, C.; Subramanian, D.; Afrasiabi, M.; Ziobro, P.; DeLucia, J.; Hirschberg, P. R.; Shiflett, M. W.; Santhakumar, V.; Tran, T. S.
10.1101/2021.06.11.448071 — neuroscience — Posted on 2021-06-11
2478 Phytochemical Nrf2 activator attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a preclinical model of musculoskeletal aging
Musci, R. V.; Andrie, K. M.; Walsh, M. A.; Valenti, Z. J.; Afzali, M. F.; Johnson, T. E.; Kail, T. E.; Martinez, R.; Nguyen, T.; Sanford, J. L.; Murrell, M. D.; McCord, J. M.; Hybertson, B. M.; Miller, B. F.; Zhang, Q.; Javors, M. A.; Santangelo, K. S.; Hamilton, K. L.
10.1101/2021.06.11.448143 — physiology — Posted on 2021-06-11
2479 Self-assembled nanoparticles enable delivery of VCP inhibitor, resulting in enhanced photoreceptor protection in retinal explants
Sen, M.; Al-Amin, M.; Kickova, E.; Sadeghi, A.; Puranen, J.; Urtti, A.; Caliceti, P.; Salmaso, S.; Arango-Gonzalez, B.; Ueffing, M.
10.1101/2021.06.11.448060 — pharmacology and toxicology — Posted on 2021-06-11
2481 HOXB8 counteracts MAPK/ERK oncogenic signaling in a chicken embryo model of neoplasia
WILMERDING, A.; BOUTEILLE, L.; RINALDI, L.; CARUSO, N.; Graba, Y.; DELFINI, M.-C.
10.1101/2021.06.11.448019 — cancer biology — Posted on 2021-06-11
2482 Glioblastoma cell fate is differentially regulated by the microenvironments of the tumour bulk and infiltrative margin
Garcia-Diaz, C.; Mereu, E.; Clements, M. P.; Pöysti, A.; Galvez-Cancino, F.; Castillo, S. P.; Courtot, L.; Ruiz, S.; Roncaroli, F.; Yuan, Y.; Quezada, S. A.; Heyn, H.; Parrinello, S.
10.1101/2021.06.11.447915 — cancer biology — Posted on 2021-06-11
2483 Effect of ligand sensing on flagellar bundle formation in bacteria
Agrawal, M.; Chakraborty, S.; Tirumkudulu, M. S.; Venkatesh, K. V.
10.1101/2021.02.11.430483 — biophysics — Posted on 2021-06-11
2487 Evolutionary and Structural Constraints Influencing Apolipoprotein A-I Amyloid Behavior
Gisonno, R. A.; Masson, T.; Ramella, N. A.; Barrera, E. E.; Romanowski, V.; Tricerri, M. A.
10.1101/2020.09.18.304337 — bioinformatics — Posted on 2021-06-11
2488 Identification of proximal SUMO-dependent interactors using SUMO-ID
Barroso-Gomila, O.; Trulsson, F.; Muratore, V.; Canosa, I.; Merino-Cacho, L.; Cortazar, A. R.; Perez, C.; Azkargorta, M.; Iloro, I.; Carracedo, A.; Aransay, A. M.; Elortza, F.; Mayor, U.; Vertegaal, A. C. O.; Barrio, R.; Sutherland, J. D.
10.1101/2020.12.28.424528 — biochemistry — Posted on 2021-06-11
2489 FDR control in GWAS with population structure
Sesia, M.; Bates, S.; Candes, E.; Marchini, J.; Sabatti, C.
10.1101/2020.08.04.236703 — genomics — Posted on 2021-06-11
2491 A reference-quality, fully annotated genome from a Puerto Rican individual
Zimin, A. V.; Shumate, A.; Shinder, I.; Heinz, J.; Puiu, D.; Pertea, M.; Salzberg, S. L.
10.1101/2021.06.10.447952 — genomics — Posted on 2021-06-11
2499 A general role for MIA3/TANGO1 in secretory pathway organization and function.
McCaughey, J.; Stevenson, N. L.; Mantell, J. M.; Neal, C. R.; Paterson, A.; Heesom, K.; Stephens, D. J.
10.1101/2021.02.24.432632 — cell biology — Posted on 2021-06-11
2501 Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice
Martino, N.; Bossardi Ramos, R.; Lu, S.; Leyden, K.; Tomaszek, L.; Sadhu, S.; Fredman, G.; Jaitovich, A.; Vincent, P. A.; Adam, A. P.
10.1101/2020.12.28.424586 — cell biology — Posted on 2021-06-11
2502 A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes
Darnaud, M.; De Vadder, F.; Bogeat, P.; Boucinha, L.; Bulteau, A.-L.; Bunescu, A.; Couturier, C.; Delgado, A.; Dugua, H.; Elie, C.; Mathieu, A.; Novotna, T.; Ouattara, D. A.; Planel, S.; Saliou, A.; Srutkova, D.; Yansouni, J.; Stecher, B.; Schwarzer, M.; Leulier, F.; Tamellini, A.
10.1101/2019.12.30.890954 — microbiology — Posted on 2021-06-11
2505 The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei
Bakari-Soale, M.; Ikenge, N. J.; Scheibe, M.; Butter, F.; Jones, N. G.; Kramer, S.; Engstler, M.
10.1101/2021.06.11.448066 — microbiology — Posted on 2021-06-11
2510 Development of the myzozoan aquatic parasite Perkinsus marinus as a versatile experimental genetic model organism
Einarsson, E.; Lassadi, I.; Zielinski, J.; Guan, Q.; Wyler, T.; Pain, A.; Gornik, S. G.; Waller, R. F.
10.1101/2021.06.11.447996 — genetics — Posted on 2021-06-11
2512 Target-Dependent Coordinated Biogenesis Ensure Cascaded Expression of miRNAs in Activated Macrophage
Chatterjee, S.; Mukherjee, I.; Bose, M.; Bhattacharjee, S.; Chakrabarti, S.; Bhattacharyya, S. N.
10.1101/2021.06.11.448041 — molecular biology — Posted on 2021-06-11
2513 A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants
Haslwanter, D.; Dieterle, M. E.; Wec, A. Z.; O'Brien, C. M.; Sakharkar, M.; Florez, C.; Tong, K.; Rappazzo, C. G.; Lasso, G.; Vergnolle, O.; Wirchnianski, A. S.; Bortz, R. H.; Laudermilch, E.; Fels, J. M.; Mengotto, A.; Malonis, R. J.; Georgiev, G. I.; Quiroz, J.; Wrapp, D.; Wang, N.; Dye, K. E.; Barnhill, J.; Dye, J. M.; McLellan, J. S.; Daily, J. P.; Lai, J. R.; Herbert, A. S.; Walker, L.; Chandran, K.; Jangra, R. K.
10.1101/2021.06.10.447999 — microbiology — Posted on 2021-06-11
2524 Mitogenomics and mitochondrial gene phylogeny decipher the evolution of Saccharomycotina yeasts
Christinaki, A. C.; Kanellopoulos, S. G.; Kortsinoglou, A. M.; Theelen, B.; Boekhout, T.; Kouvelis, V. N.
10.1101/2021.06.11.448017 — evolutionary biology — Posted on 2021-06-11
2529 Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium
Neumann, M.; Steimle, A.; Grant, E. T.; Wolter, M.; Parrish, A.; Willieme, S.; Brenner, D.; Martens, E.; Desai, M. S.
10.1101/2021.06.11.448035 — microbiology — Posted on 2021-06-11
2530 B.1.1.7 and B.1.351 SARS-CoV-2 variants display enhanced Spike-mediated fusion
Rajah, M. M.; Hubert, M.; Bishop, E.; Saunders, N.; Robinot, R.; Grzelak, L.; Planas, D.; Zivaljic, M.; Planchais, C.; Guivel-Benhassine, F.; Porrot, F.; Mouquet, H.; Chakrabarti, L.; Buchrieser, J.; Schwartz, O.
10.1101/2021.06.11.448011 — microbiology — Posted on 2021-06-11
2532 High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells
Chen, J. S.; Chow, R. D.; Song, E.; Mao, T.; Israelow, B.; Kamath, K.; Bozekowski, J.; Haynes, W. A.; Filler, R. B.; Menasche, B. L.; Wei, J.; Alfajaro, M. M.; Song, W.; Peng, L.; Carter, L.; Weinstein, J. S.; Gowthaman, U.; Chen, S.; Craft, J.; Shon, J. C.; Iwasaki, A.; Wilen, C. B.; Eisenbarth, S. C.
10.1101/2021.06.10.447982 — immunology — Posted on 2021-06-11
2536 Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies
Elsemman, I. E.; Rodrigues Prado, A.; Grigaitis, P.; Garcia Albornoz, M.; Harman, V.; Holman, S.; van Heerden, J.; Bruggeman, F. J.; Bisschops, M. M. M.; Sonnenschein, N.; Hubbard, S.; Beynon, R.; Daran-Lapujade, P.; Nielsen, J.; Teusink, B.
10.1101/2021.06.11.448029 — systems biology — Posted on 2021-06-11
2537 INDEHISCENT regulates explosive seed dispersal
Galstyan, A.; Sarchet, P.; Campos-Martin, R.; Adibi, M.; Nikolov, L. A.; Perez Anton, M.; Hofhuis, H.; Rambaud-Lavigne, L.; Gan, X.; Hay, A.
10.1101/2021.06.11.448014 — plant biology — Posted on 2021-06-11
2538 Ectopic expression of lipid homeostasis genes in rare cells of the teleost pituitary gland
Ager-Wick, E.; Maugars, G.; von Krogh, K.; Fontaine, R.; Siddique, K.; Nourizadeh-Lillabadi, R.; Weltzien, F.-A.; Henkel, C.
10.1101/2021.06.11.448009 — physiology — Posted on 2021-06-11
2541 Does time matter in phylogeny? A perspective from the fossil record
Guenser, P.; Warnock, R. C. M.; Donoghue, P. C. J.; Jarochowska, E.
10.1101/2021.06.11.445746 — paleontology — Posted on 2021-06-11
2544 Deep integrative models for large-scale human genomics
Sigurdsson, A. I.; Westergaard, D.; Winther, O.; Lund, O.; Brunak, S.; Vilhjalmsson, B. J.; Rasmussen, S.
10.1101/2021.06.11.447883 — bioinformatics — Posted on 2021-06-11
2545 An efficient GUI-based clustering software for simulation and Bayesian cluster analysis of single-molecule localization microscopy data
Kutz, S.; Zehrer, A. C.; Svetlitckii, R.; Gulculer Balta, G. S.; Galli, L.; Kleber, S.; Martin-Villalba, A.; Ewers, H.
10.1101/2021.06.11.447933 — bioinformatics — Posted on 2021-06-11
2548 Neutralizing antibodies elicited by the Ad26.COV2.S COVID-19 vaccine show reduced activity against 501Y.V2 (B.1.351), despite protection against severe disease by this variant.
Moore, P.; Moyo, T.; Hermanus, T.; Kgagudi, P.; Ayres, F.; Makhado, Z.; Sadoff, J.; Le Gars, M.; van Roey, G.; Crowther, C.; Garrett, N.; Bekker, L.-G.; Morris, L.; Schuitemaker, H.; Gray, G.
10.1101/2021.06.09.447722 — immunology — Posted on 2021-06-11
2549 Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes
Bhardwaj, T.; Gadhave, K.; Kapuganti, S. K.; Kumar, P.; Brotzakis, Z. F.; Saumya, K. U.; Nayak, N.; Kumar, A.; Garg, N.; Vendruscolo, M.; Giri, R.
10.1101/2021.05.29.446267 — biophysics — Posted on 2021-06-11
2550 Niche shifts and hybridization in two Amazona parrot sister-species introduced to Southern California
Maley, J. M.; Freeland, R. J.; DeRaad, D. A.; Zellmer, A. J.; Schedl, M. E.; Durham, B.; Tsai, W. L. E.; Terrill, R. S.; Sannapareddy, S.; Garrett, K. L.; McCormack, J. E.
10.1101/2021.03.11.435041 — evolutionary biology — Posted on 2021-06-11
2551 Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein
Glon, D.; Vilmen, G.; Perdiz, D.; Hernandez, E.; Beauclair, G.; Maréchal, V.; Poüs, C.; Lussignol, M.; Esclatine, A.
10.1101/2021.06.11.448012 — cell biology — Posted on 2021-06-11
2552 ROS/RNS balancing, aerobic fermentation regulation and cell cycle control a complex early trait ('CoV-MAC-TED') for combating SARS-CoV-2-induced cell reprogramming
Costa, J. H.; Mohanapriya, G.; Revuru, B.; Noceda, C.; Thiers, K. L. L.; Aziz, S.; Srivatsava, S.; Oliveira, M.; Gupta, K. J.; Kumari, A.; Sircar, D.; Kumar, S. R.; Achra, A.; Sathishkumar, R.; Adhloeya, A.; Arnholdt-Schmitt, B.
10.1101/2021.06.08.447491 — cell biology — Posted on 2021-06-11
2554 Longitudinal immune dynamics of mild COVID-19 define signatures of recovery and persistence
Talla, A.; Vasaikar, S. V.; Lemos, M. P.; Moodie, Z.; Pebworth, M.-P. L.; Henderson, K. E.; Cohen, K. W.; Czartoski, J. L.; Lai, L.; Suthar, M. S.; Heubeck, A. T.; Genge, P. C.; Roll, C. M.; Weiss, M.; Reading, J.; Kondza, N.; MacMillan, H.; Fong, O. C.; Thomson, Z. J.; Graybuck, L. T.; Newell, E. W.; Coffey, E. M.; Meijer, P.; Becker, L. A.; De Rosa, S. C.; Torgerson, T. R.; Skene, P. J.; Li, X.; Szeto, G. L.; McElrath, M. J.; Bumol, T. F.
10.1101/2021.05.26.442666 — immunology — Posted on 2021-06-11
2555 Spatial neglect in the digital age - Influence of presentation format on patients' test behavior
Rosenzopf, H.; Sperber, C.; Wortha, F.; Wiesen, D.; Muth, A.; Klein, E.; Moeller, K.; Karnath, H.-O.
10.1101/2021.06.11.447882 — neuroscience — Posted on 2021-06-11
2556 Unraveling the functions of uncharacterized transcription factors in Escherichia coli using ChIP-exo
Gao, Y.; Lim, H. G.; Verkler, H.; Szubin, R.; Quach, D.; Rodionova, I.; Chen, K.; Yurkovich, J.; Cho, B.-K.; Palsson, B. O.
10.1101/2021.06.10.447994 — systems biology — Posted on 2021-06-11
2561 Genomic consequences of colonisation, migration and genetic drift in barn owl insular populations of the eastern Mediterranean
Machado, A. P.; Topaloudis, A.; Cumer, T.; Lavanchy, E.; Bontzorlos, V.; Ceccherelli, R.; Charter, M.; Kassinis, N.; Lymberakis, P.; Manzia, F.; Ducrest, A.-L.; Dupasquier, M.; Guex, N.; Roulin, A.; Goudet, J.
10.1101/2021.06.10.447833 — evolutionary biology — Posted on 2021-06-11
2562 MKP-1 modulates Ubiquitination/Phosphorylation of TLR signaling
Talreja, J.; Bauerfeld, C.; Wang, X.; Hafner, M.; Liu, Y.; Samavati, L.
10.1101/2021.06.10.447995 — immunology — Posted on 2021-06-11
2563 Profiling Human CMV-specific T cell responses reveals novel immunogenic ORFs
Dhanwani, R.; Dhanda, S. K.; Pham, J.; Williams, G. P.; Sidney, J.; Grifoni, A.; Picarda, G.; Lindestam Arleham, C.; Sette, A.; Benedict, C. A.
10.1101/2021.06.10.447997 — immunology — Posted on 2021-06-11
2569 Measuring the metabolic evolution of glioblastoma throughout tumor development, regression, and recurrence with hyperpolarized magnetic resonance
Salzillo, T. C.; Mawoneke, V.; Weygand, J.; Shetty, A.; Gumin, J.; Zacharias Millward, N. M.; Gammon, S. T.; Piwnica-Worms, D.; Fuller, G. N.; Logothetis, C. J.; Lang, F. F.; Bhattacharya, P. K.
10.1101/2021.06.10.447987 — biophysics — Posted on 2021-06-11
2573 A putative de novo evolved gene required for spermatid chromatin condensation in Drosophila melanogaster
Rivard, E. L.; Ludwig, A. G.; Patel, P. H.; Grandchamp, A.; Arnold, S. E.; Berger, A.; Scott, E. M.; Kelly, B. J.; Mascha, G. C.; Bornberg-Bauer, E.; Findlay, G. D.
10.1101/2021.06.10.447990 — genetics — Posted on 2021-06-11
2575 Greenland's thaw pushes the biodiversity crisis
Ureta, C.; Ramirez-Barahona, S.; Calderon-Bustamante, O.; Cruz-Santiago, P.; Gay-Garcia, C.; Swingedouw, D.; DeFrance, D.; Cuervo-Robayo, A. P.
10.1101/2021.06.10.447623 — ecology — Posted on 2021-06-11
2577 Sustained mechanical tension governs fibrogenic activation of tendon stromal cells in systemic sclerosis
Hussien, A. A.; Knell, R.; Renoux, F.; Wunderli, S.; Niederoest, B.; Foolen, J.; Distler, O.; Snedeker, J. G.
10.1101/2021.06.11.445955 — cell biology — Posted on 2021-06-11
2579 Consciousness is supported by near-critical cortical electrodynamics
Toker, D.; Pappas, I.; Lendner, J. D.; Frohlich, J.; Mateos, D. M.; Muthukumaraswamy, S.; Carhart-Harris, R.; Paff, M.; Vespa, P. M.; Monti, M. M.; Sommer, F. T.; Knight, R. T.; D'Esposito, M.
10.1101/2021.06.10.447959 — neuroscience — Posted on 2021-06-11
2580 Autonomic and respiratory components of orienting behaviors are mediated by descending pathways originating from the superior colliculus
Lynch, E.; Dempsey, B. R.; Monteiro, E.; Turner, A. J.; Saleeba, C.; Burke, P. G.; Allen, A. M.; Dampney, R. A.; Hildreth, C. M.; Cornish, J. L.; Goodchild, A. K.; McMullan, S.
10.1101/2021.06.10.447470 — neuroscience — Posted on 2021-06-11
2582 Diverse routes of Club cell evolution in lung adenocarcinoma
Chen, Y.; Toth, R.; Chocarro, S.; Weichenhan, D.; Hey, J.; Lutsik, P.; Sawall, S.; Stathopoulos, G. T.; Plass, C.; Sotillo, R.
10.1101/2021.06.10.447936 — cancer biology — Posted on 2021-06-11
2585 A Novel Local Ablation Approach for Explaining Multimodal Classifiers
Ellis, C. A.; Carbajal, D. A.; Zhang, R.; Sendi, M. S. E.; Miller, R. L.; Calhoun, V.; Wang, M. D.
10.1101/2021.06.10.447986 — bioinformatics — Posted on 2021-06-11
2586 A reference-quality, fully annotated genome from a Puerto Rican individual
Zimin, A. V.; Shumate, A.; Shinder, I.; Heinz, J.; Puiu, D.; Pertea, M.; Salzberg, S. L.
10.1101/2021.06.10.447952 — genomics — Posted on 2021-06-11
2587 Development of the Wheat Practical Haplotype Graph Database as a Resource for Genotyping Data Storage and Genotype Imputation
Jordan, K.; Bradbury, P.; Miller, Z. R.; Nyine, M.; He, F.; Fraser, M.; Anderson, J.; Mason, E.; Katz, A.; Pearce, S.; Carter, A. H.; Prather, S.; Pumphrey, M.; Chen, J.; Cook, J.; Liu, S.; Rudd, J.; Wang, Z.; Chu, C.; Ibrahim, A. M. H.; Turkus, J.; Olson, E.; Nagarajan, R.; Carver, B.; Yan, L.; Taagen, E.; Sorrells, M. E.; Ward, B.; Ren, J.; Akhunova, A.; Bai, G.; Bowden, R.; Fiedler, J.; Faris, J.; Dubcovsky, J.; Guttieri, M.; Brown-Guedira, G.; Buckler, E. S.; Jannink, J.-L.; Akhunov, E.
10.1101/2021.06.10.447944 — genomics — Posted on 2021-06-11
2588 Pvr and downstream signaling factors are required for spreading of Drosophila hemocytes at larval wound sites
Galko, M. J.; Tsai, C.-R.; Jacobson, A.; Sankoorikal, N.; Chirinos, J. D.; Burra, S.; Wang, Y.; Maktal, N.; Kumaraswami, M.
10.1101/2021.06.10.447972 — genetics — Posted on 2021-06-11
2590 Brain-wide quantification of the supraspinal connectome
Wang, Z.; Romanski, A.; Mehra, V.; Wang, Y.; Campbell, B. C.; Petsko, G. A.; Tsoulfas, P.; Blackmore, M. G.
10.1101/2021.06.10.447885 — neuroscience — Posted on 2021-06-11
2591 Towards rainy Arctic winters: experimental icing impacts tundra plant productivity and reproduction
Le Moullec, M.; Hendel, A.-L.; Petit Bon, M.; Jonsdottir, I. S.; Varpe, O.; van der Wal, R.; Beumer, L.; Layton-Matthews, K.; Isaksen, K.; Hansen, B. B.
10.1101/2021.06.10.447955 — plant biology — Posted on 2021-06-11
2592 Geometric Network Analysis Provides Prognostic Information in Patients with High Grade Serous Carcinoma of the Ovary Treated with Immune Checkpoint Inhibitors
Elkin, R.; Oh, J. H.; Liu, Y. L.; Selenica, P.; Weigelt, B.; Reis-Filho, J. S.; Zamarin, D.; Deasy, J. O.; Norton, L.; Levine, A. J.; Tannenbaum, A. R.
10.1101/2021.06.10.447889 — cancer biology — Posted on 2021-06-11
2593 A high-quality functional genome assembly of Delia radicum L. (Diptera: Anthomiidae) annotated from egg to adult
Sontowski, R.; Poeschl, Y.; Okamura, Y.; Vogel, H.; Guyomar, C.; Cortesero, A.-M.; van Dam, N. M.
10.1101/2021.06.11.447147 — genomics — Posted on 2021-06-11
2594 WDR31 is a novel ciliopathy protein displaying functional redundancy with GTPase-activating proteins ELMOD and RP2 in recruiting BBSome to cilium
Cevik, S.; Alabdi, L.; Peng, X.; Beyer, T.; Zorluer, A.; Pir, M. S.; Yenisert, F.; Shaheen, R.; Woerz, F.; Hoffmann, F.; Altunkaynak, B.; Pir, B.; Boldt, K.; Karaman, A.; Cakiroglu, M.; Oner, S. S.; Cao, Y.; Ueffing, M.; Alkuraya, F. S.; Kaplan, O. I.
10.1101/2021.06.10.445528 — genetics — Posted on 2021-06-11
2595 The asymmetric Pitx2 regulates intestinal muscular-lacteal development and protects against fatty liver disease
Kurpios, N. A.; Hu, S.; Mahadevan, A.; Elysee, I. F.; Choi, J.; Souchet, N. R.; Bae, G. H.; Taboada, A. K.; Duhamel, G. E.; Sevier, C. S.; Tao, G.
10.1101/2021.06.11.447753 — developmental biology — Posted on 2021-06-11
2597 Mitochondrial COA7 is a heme-binding protein involved in the early stages of complex IV assembly.
Formosa, L. E.; Maghool, S.; Sharpe, A. J.; Reljic, B.; Muellner-Wong, L.; Stroud, D. A.; Ryan, M.; Maher, M. J.
10.1101/2021.06.10.447992 — biochemistry — Posted on 2021-06-11
2598 Engineered AIM-based Selective Autophagy to Degrade Proteins and Organelles
Luo, N.; Shang, D.; Tang, Z.; Huang, X.; Tao, L.-Z.; Liu, L.; Gao, C.; Qian, Y.; Xie, Q.; Li, F.
10.1101/2021.06.11.448008 — cell biology — Posted on 2021-06-11
2599 Bolstering fitness via opportunistic CO2 fixation: mixotroph dominance in modern groundwater
Taubert, M.; Overholt, W. A.; Heinze, B. M.; Azemtsop, G.; Houhou, R.; Jehmlich, N.; von Bergen, M.; Roesch, P.; Popp, J.; Kuesel, K.
10.1101/2021.01.26.428071 — microbiology — Posted on 2021-06-11
2601 Normal Aging in Mice is Associated with a Global Reduction in Cortical Spectral Power and Network-Specific Declines in Functional Connectivity
Albertson, A. J.; Landsness, E. C.; Tang, M. J.; Yan, P.; Miao, H.; Rosenthal, Z. P.; Kim, B.; Culver, J. C.; Bauer, A. Q.; Lee, J.-M.
10.1101/2021.06.09.447772 — neuroscience — Posted on 2021-06-11
2603 Unified classification of mouse retinal ganglion cells using function, morphology, and gene expression
Goetz, J.; Jessen, Z. F.; Jacobi, A.; Mani, A.; Cooler, S.; Greer, D.; Kadri, S.; Segal, J.; Shekhar, K.; Sanes, J.; Schwartz, G.
10.1101/2021.06.10.447922 — neuroscience — Posted on 2021-06-11
2604 The role of hub neurons in modulating cortical dynamics
Gal, E.; Amsalem, O.; Schindel, A.; London, M.; Schuermann, F.; Markram, H.; Segev, I.
10.1101/2021.06.11.448003 — neuroscience — Posted on 2021-06-11
2605 Neural precursor grafts restore motor and non-motor functions in parkinsonian macaques
Wianny, F.; Dzahini, K.; Fifel, K.; Wilson, C. R. E.; Bernat, A.; Dolmazon, V.; Misery, P.; Lamy, C.; Knoblauch, K.; Cooper, H. M.; Procyk, E.; Kennedy, H.; Savatier, P.; Dehay, C.; Vezoli, J.
10.1101/2020.12.17.423293 — neuroscience — Posted on 2021-06-11
2606 High-level language brain regions are sensitive to sub-lexical regularities
Regev, T. I.; Affourtit, J.; Chen, X.; Schipper, A. E.; Bergen, L.; Mahowald, K.; Fedorenko, E.
10.1101/2021.06.11.447786 — neuroscience — Posted on 2021-06-11
2608 NDR1 and the Arabidopsis Plasma Membrane ATPase AHA5 are Required for Processes that Converge on Drought Tolerance and Immunity
Lu, Y.-J.; Chen, H.; Corrion, A.; Li, P.; Buyuk, I.; Samaradivakara, S.; Wai, C.-M.; Sakamoto, H.; Santos, P. F.; VanBuren, R.; Kim, Y.; Day, B.
10.1101/2021.06.10.445978 — plant biology — Posted on 2021-06-11
2610 Pervasive fold switching in a ubiquitous protein superfamily
Porter, L.; Kim, A. K.; Looger, L. L.; Majumdar, A.; Starich, M. R.
10.1101/2021.06.10.447921 — bioinformatics — Posted on 2021-06-11
2615 The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway
Hollomon, J.; Liu, Z.; Rusin, S.; Jenkins, N. P.; Smith, A. K.; Koeppen, K.; Kettenbach, A. N.; Myers, L. C.; Hogan, D. A.
10.1101/2021.06.10.447844 — microbiology — Posted on 2021-06-11
2616 Using structurally fungible biosensors to evolve improved alkaloid biosyntheses
d'Oelsnitz, S.; Kim, W.; Burkholder, N. T.; javanmardi, K.; Thyer, R.; Zhang, Y.; Alper, H. S.; Ellington, A.
10.1101/2021.06.07.447399 — synthetic biology — Posted on 2021-06-11
2617 Emerging single cell endothelial heterogeneity supports sprouting tumour angiogenesis and growth
Matsumoto, K.; Rambow, F.; Stanchi, F.; Mathivet, T.; Qian, J.; Giese, W.; He, L.; Lambrechts, D.; Zhou, B.; Betsholtz, C.; Marine, J.-C.; Gerhardt, H.
10.1101/2021.06.09.447719 — cancer biology — Posted on 2021-06-11
2619 Three-dimensional organization of chromatin associated RNAs and their role in chromatin architecture in human cells
Calandrelli, R.; Wen, X.; Nguyen, T. C.; Chen, C.-J.; Qi, Z.; Chen, W.; Yan, Z.; Wu, W.; Zaleta-Rivera, K.; Hu, R.; Yu, M.; Wang, Y.; Ma, J.; Ren, B.; Zhong, S.
10.1101/2021.06.10.447969 — genomics — Posted on 2021-06-11
2620 Oxaliplatin kills cells via liquid-liquid demixing of nucleoli
Schmidt, H. B.; Jaafar, Z.; Rodencal, J. J.; Leonetti, M. D.; Dixon, S. J.; Rohatgi, R.; Brandman, O.
10.1101/2021.06.10.447918 — cell biology — Posted on 2021-06-11
2621 A DNA Replication-Independent Function of the pre-Replication Complex during Cell Invasion in C. elegans
Lattmann, E.; Deng, T.; Walser, M.; Widmer, P.; Rexha-Lambert, C.; Prasad, V.; Eichhoff, O.; Daube, M.; Dummer, R.; Levesque, M.; Hajnal, A.
10.1101/2021.06.10.447853 — cell biology — Posted on 2021-06-11
2622 Analysis of subcellular transcriptomes by RNA proximity labeling with Halo-seq
Engel, K. L.; Lo, H.-Y. G.; Goering, R.; Li, Y.; Spitale, R.; Taliaferro, J. M.
10.1101/2021.06.08.447604 — molecular biology — Posted on 2021-06-11
2624 Surfactin stimulated by pectin molecular patterns and root exudates acts as a key driver of Bacillus-plant mutualistic interaction
Hoff, G.; Arguelles Arias, A.; Boubsi, F.; Prsic, J.; Meyer, T.; Ibrahim, H. M. M.; Steels, S.; Luzuriaga, P.; Legras, A.; Franzil, L.; Lequart, M.; Rayon, C.; Osorio, V.; de Pauw, E.; Lara, Y.; Deboever, E.; de Coninck, B.; Jacques, P.; Deleu, M.; Petit, E.; Van Wuytswinkel, O.; Ongena, M.
10.1101/2021.02.22.432335 — microbiology — Posted on 2021-06-11
2625 The oxygen sensor Prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells
Ajouaou, Y.; Azouz, A.; Taquin, A.; Hussein, H.; Andris, F.; Moser, M.; Goriely, S.; Leo, O.
10.1101/2021.03.23.436597 — immunology — Posted on 2021-06-11
2632 FDR control in GWAS with population structure
Sesia, M.; Bates, S.; Candes, E.; Marchini, J.; Sabatti, C.
10.1101/2020.08.04.236703 — genomics — Posted on 2021-06-11
2633 Recovery of trait heritability from whole genome sequence data
Wainschtein, P.; Jain, D. P.; Zheng, Z.; TOPMed Anthropometry Working Group, ; Trans-Omics for Precision Medicine Consortium, ; Cupples, L. A.; Shadyab, A. H.; McKnight, B.; Shoemaker, B. M.; Mitchell, B. D.; Psaty, B. M.; Kooperberg, C.; Liu, C.-T.; Albert, C. M.; Roden, D.; Chasman, D. I.; Darbar, D.; Lloyd-Jones, D. M.; Arnett, D. K.; Regan, E. A.; Boerwinkle, E.; Rotter, J. I.; O'Connell, J. R.; Yanek, L. R.; de Andrade, M.; Allison, M. A.; McDonald, M.-L. N.; Chung, M. K.; Fornage, M.; Chami, N.; Smith, N. L.; Ellinor, P. T.; Vasan, R. S.; Mathias, R. A.; Loos, R. J. F.; Rich, S. S.; Lu
10.1101/588020 — genetics — Posted on 2021-06-11
2636 Allelic expression analysis of Imprinted and X-linked genes from bulk and single-cell transcriptomes
Martini, P.; Sales, G.; Diamante, L.; Perrera, V.; Colantuono, C.; Riccardo, S.; Cacchiarelli, D.; Romualdi, C.; Martello, G.
10.1101/2020.05.20.105841 — bioinformatics — Posted on 2021-06-10
2638 Adaptive reprogramming during early seed germination requires temporarily enhanced fermentation a critical role for alternative oxidase (AOX) regulation that concerns also microbiota effectiveness
Revuru, B.; Noceda, C.; Gunasekharan, M.; Kumar, S. R.; Thiers, K. L. L.; Costa, J. H.; Macedo, E. S.; Kumari, A.; Gupta, K. J.; Srivatsava, S.; Adhloeya, A.; Oliveira, M.; Velada, I.; Sircar, D.; Sathishkumar, R.; Arnholdt-Schmitt, B.
10.1101/2021.06.08.447570 — cell biology — Posted on 2021-06-10
2644 Dietary habits of free-ranging banded langur (Presbytis femoralis) in a secondary-human modified forest in Johor, Malaysia
Najmuddin, M. F.; Haris, H.; Norazlimi, N.; Ruslin, F.; Matsuda, I.; Md-Zain, B. M.; Abdul-Latiff, M. A. B.
10.1101/2021.03.16.435588 — ecology — Posted on 2021-06-10
2645 A deep generative model of 3D single-cell organization
Donovan-Maiye, R.; Brown, J.; Chan, C.; Ding, L.; Yan, C.; Gaudreault, N.; Theriot, J.; Maleckar, M.; Knijnenburg, T. A.; Johnson, G.
10.1101/2021.06.09.447725 — cell biology — Posted on 2021-06-10
2646 Fine-scale adaptations to environmental variation and growth strategies drive phyllosphere Methylobacterium diversity.
Leducq, J.-B.; Seyer-Lamontagne, E.; Condrain-Morel, D.; Bourret, G.; Sneddon, D.; Foster, J. A.; Marx, C. J.; Sullivan, J. M.; Shapiro, B. J.; Kembel, S. W.
10.1101/2021.06.04.447128 — microbiology — Posted on 2021-06-10
2647 Transcriptomic similarities and differences between mouse models and human Alzheimer's Disease
De Bastiani, M. A.; Bellaver, B.; Carello-Collar, G.; Forner, S.; Martini, A. C.; Pascoal, T. A.; Zimmer, E. R.
10.1101/2021.06.09.447404 — neuroscience — Posted on 2021-06-10
2648 Normal Aging in Mice is Associated with a Global Reduction in Cortical Spectral Power and a Network-Specific Declines in Functional Connectivity
Albertson, A. J.; Landsness, E. C.; Tang, M. J.; Yan, P.; Miao, H.; Rosenthal, Z. P.; Kim, B.; Culver, J. C.; Bauer, A. Q.; Lee, J.-M.
10.1101/2021.06.09.447772 — neuroscience — Posted on 2021-06-10
2649 Hematopoietic differentiation is characterized by a transient peak of entropy at a single cell level.
Dussiau, C.; Boussaroque, A.; Gaillard, M.; Bravetti, C.; Zaroili, L.; Knosp, C.; Friedrich, C.; Asquier, P.; Willems, L.; Quint, L.; Bouscary, D.; Fontenay, M.; Espinasse, T.; Plesa, A.; Sujobert, P.; Gandrillon, O.; Kosmider, O.
10.1101/2021.04.30.442092 — systems biology — Posted on 2021-06-10
2650 Ovule siRNAs methylate and silence protein-coding genes in trans
Burgess, D.; Chow, H. T.; Grover, J. W.; Freeling, M.; Mosher, R. A.
10.1101/2021.06.10.447945 — plant biology — Posted on 2021-06-10
2655 Selective sweeps influence diversity over large regions of the mouse genome
Booker, T. R.; Jackson, B. C.; Craig, R. J.; Keightley, P. D.; Charlesworth, B.
10.1101/2021.06.10.447924 — evolutionary biology — Posted on 2021-06-10
2657 Lysosome Lipid Signaling from the Periphery to Neurons Regulates Longevity
Savini, M.; Duffy, J. D.; Folick, A.; Lee, Y.-T.; Hu, P.-W.; Neve, I.; Jin, F.; Zhang, Q.; Tillman, M.; Ye, Y.; Mair, W.; Wang, J.; Han, L.; Ortlund, E.; Wang, M. C.
10.1101/2021.06.10.447794 — cell biology — Posted on 2021-06-10
2658 A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection.
Vijayan, K.; Arang, N.; Wei, L.; Morrison, R.; Geiger, R.; Parks, R. K.; Lewis, A. J.; Mast, F. D.; Douglass, A. N.; Kain, H. S.; Aitchison, J. D.; Johnson, J. S.; Aderem, A.; Kaushansky, A.
10.1101/2020.08.31.275867 — cell biology — Posted on 2021-06-10
2660 A ciliopathy complex builds distal appendages to initiate ciliogenesis
Kumar, D.; Rains, A.; Herranz-Perez, V.; Lu, Q.; Shi, X.; Swaney, D. L.; Stevenson, E.; Krogan, N. J.; Huang, B.; Westlake, C.; Garcia-Verdugo, J. M.; Yoder, B.; Reiter, J.
10.1101/2021.03.01.433418 — cell biology — Posted on 2021-06-10
2661 DNA methylation patterns in bacteria of the genus Ensifer during free living growth and during nitrogen-fixing symbiosis with Medicago spp.
diCenzo, G. C.; Cangioli, L.; Nicoud, Q.; Cheng, J. H. T.; Blow, M. J.; Shapiro, N.; Woyke, T.; Biondi, E. G.; Alunni, B.; Mengoni, A.; Mergaert, P.
10.1101/2021.03.08.434416 — microbiology — Posted on 2021-06-10
2662 Low numbers of cytokine transcripts drive inflammatory skin diseases by initiating amplification cascades in localized epidermal clusters
Schaebitz, A.; Hillig, C.; Farnoud, A.; Jargosch, M.; Scala, E.; Pilz, A. C.; Bhalla, N.; Mubarak, M.; Thomas, J.; Stahle, M.; Biedermann, T.; Schmidt-Weber, C. B.; Theis, F. J.; Garzorz-Stark, N.; Eyerich, K.; Menden, M. P.; Eyerich, S.
10.1101/2021.06.10.447894 — immunology — Posted on 2021-06-10
2663 MARCO+ lymphatic endothelial cells sequester arboviruses to limit viremia and viral dissemination
Carpentier, K. S.; Sheridan, R. M.; Lucas, C. J.; Davenport, B. J.; Li, F. S.; Lucas, E. D.; McCarthy, M. K.; Reynoso, G. V.; May, N. A.; Tamburini, B. A.; Hesselberth, J. R.; Hickman, H. D.; Morrison, T. E.
10.1101/2021.06.10.447957 — immunology — Posted on 2021-06-10
2664 Bipolar-associated miR-499-5p controls neuroplasticity by downregulating the Cav1.2 L-type voltage gated calcium channel subunit CACNB2
Martins, H. C.; Sungur, O. A.; Gilardi, C.; Pelzl, M.; Bicker, S.; Gross, F.; Winterer, J.; Kisko, T. M.; Braun, M. D.; Brosch, K.; Nenadic, I.; Stein, F.; Meinert, S.; Schwarting, R. K.; Dannlowski, U.; Kircher, T.; Woehr, M.; Schratt, G.
10.1101/2021.06.09.447782 — neuroscience — Posted on 2021-06-10
2665 Neural dynamics of semantic categorization in semantic variant of Primary Progressive Aphasia.
Borghesani, V.; Dale, C. L.; Lukic, S.; Hinkley, L. B. N.; Lauricella, M.; Shwe, W.; Miziuri, D.; Honma, S.; Miller, Z.; Miller, B. L.; Houde, J.; Gorno-Tempini, M. L.; Nagarajan, S.
10.1101/2020.10.07.329698 — neuroscience — Posted on 2021-06-10
2668 All-optical mechanobiology interrogation of YAP in human cancer and normal cells using a novel multi-functional system
Luo, Q.; Huang, M.; Liang, C.; Zhang, J.; Lin, G.; Yu, S.; Tanaka, M.; Lepler, S.; Guan, J.; Siemann, D.; Tang, X.
10.1101/2021.06.09.447829 — biophysics — Posted on 2021-06-10
2669 Height, but not binding epitope, affects the potency of synthetic TCR agonists
Wilhelm, K. B.; Morita, S.; McAffee, D. B.; Kim, S.; O'Dair, M. K.; Groves, J. T.
10.1101/2021.05.13.443919 — biophysics — Posted on 2021-06-10
2672 Identification of ACE2 modifiers by CRISPR screening
Sherman, E. J.; Mirabelli, C.; Tang, V. T.; Khan, T. G.; Kennedy, A. A.; Graham, S. E.; Willer, C.; Tai, A. W.; Sexton, J. Z.; Wobus, C. E.; Emmer, B. T.
10.1101/2021.06.10.447768 — genomics — Posted on 2021-06-10
2673 A CRISPR toolbox for generating intersectional genetic mice for functional, molecular, and anatomical circuit mapping
Lusk, S.; McKinney, A.; Hunt, P. J.; Fahey, P. G.; Patel, J.; Sun, J. J.; Martinez, V. K.; Zhu, P. J.; Egbert, J. R.; Jiang, X.; Arenkiel, B. R.; Tolias, A. S.; Costa-Mattioli, M.; Ray, R. S.
10.1101/2021.06.10.447908 — genetics — Posted on 2021-06-10
2676 Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes
Vicencio, J.; Sanchez-Bolanos, C.; Moreno-Sanchez, I.; Brena, D.; Kukhtar, D.; Ruiz-Lopez, M.; Cots-Ponjoan, M.; Vejnar, C. E.; Rubio, A.; Rodrigo Melero, N.; Carolis, C.; Perez-Pulido, A. J.; Giraldez, A. J.; Kleinstiver, B. P.; Ceron, J.; Moreno-Mateos, M. A.
10.1101/2021.06.06.447255 — genetics — Posted on 2021-06-10
2677 hei-tag: a highly efficient tag to boost targeted genome editing
Thumberger, T.; Tavhelidse, T.; Gutierrez-Triana, J. A.; Medert, R.; Cornean, A.; Welz, B.; Freichel, M.; Wittbrodt, J.
10.1101/2021.05.27.445956 — genetics — Posted on 2021-06-10
2682 Expansion of RNA sequence diversity and RNA editing rates throughout human cortical development
Cuddleston, R.; Sloofman, L.; Liang, L.; Mossotto, E.; Fan, X.; Wang, M.; Zhang, B.; Wang, J.; Sestan, N.; Devlin, B.; Roeder, K.; Buxbaum, J. D.; Sanders, S.; Breen, M. S.
10.1101/2021.06.10.447947 — developmental biology — Posted on 2021-06-10
2684 Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway
Kweon, H. Y.; Lee, M.; Dorfel, M.; Seo, S.; Gottlieb, L.; PaPazyan, T.; McTiernan, N.; Ree, R.; Bolton, D.; Garcia, A.; Flory, M.; Crain, J.; Sebold, A.; Lyons, S.; Ismail, A.; Marchi, E.; Sonn, S.-k.; Jeong, S.-J.; Jeon, S.; Ju, S.; Conway, S. J.; Kim, T.; Kim, H.-S.; Lee, C.; Roh, T.-Y.; Arnesen, T.; Marmorstein, R.; Oh, G.; Lyon, G. J.
10.1101/2020.12.19.422860 — developmental biology — Posted on 2021-06-10
2685 Steady-State Regulation of Secretory Cargo Export by Inositol Trisphosphate Receptors and Penta-EF-Hand Proteins
Held, A.; Sargeant, J.; Hojanazarova, J.; Madreiter-Sokolowski, C.; Mali, R.; Graier, W. F.; Hay, J. C.
10.1101/2020.06.13.150144 — cell biology — Posted on 2021-06-10
2686 Lyso-Phosphatidic Acid Acyl-Transferases: a link with intracellular protein transport in Arabidopsis root cells?
Wattelet-Boyer, V.; Le-Guedard, M.; Dittrich-Domergue, F.; Maneta-Peyret, L.; Kriechbaumer, V.; Boutte, Y.; Bessoule, J.-J.; Moreau, P.
10.1101/2021.06.08.447563 — cell biology — Posted on 2021-06-10
2688 ALG-2 And Peflin Stimulate or Inhibit COPII Targeting And Secretion In Response To Calcium Signaling
Sargeant, J.; Seiler, D.; Costain, T.; Madreiter-Sokolowski, C. T.; Gordon, D. E.; Peden, A. A.; Malli, R.; Graier, W. F.; Hay, J. C.
10.1101/2020.02.22.944264 — cell biology — Posted on 2021-06-10
2689 A deep learning approach to capture the essence of Candida albicans morphologies
Bettauer, V.; Costa, A. C.; Omran, R. P.; Massahi, S.; Kirbizakis, E.; Simpson, S.; Dumeaux, V.; Law, C.; Whiteway, M.; Hallett, M. T.
10.1101/2021.06.10.445299 — microbiology — Posted on 2021-06-10
2691 Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host
Adewale, B.; Pastore, C. F.; Rossi, H. L.; Hung, L.-Y.; Bethony, J.; Diemert, D.; Babatunde, J. A.; Herbert, D.
10.1101/2021.06.10.447912 — immunology — Posted on 2021-06-10
2692 PD-1 checkpoint blockade disrupts CD4 T cell regulated adaptive B cell tolerance to foreign antigens
Dufaud, C. R.; Shuparski, A. G.; Higgins, B. W.; McHeyzer-Williams, L. J.; McHeyzer-Williams, M. G.
10.1101/2021.06.10.447979 — immunology — Posted on 2021-06-10
2693 Multiscale dynamics underlying neocortical slow oscillations
Mattia, M.; Perez-Zabalza, M.; Tort-Colet, N.; Dasilva, M.; Munoz, A.; Sanchez-Vives, M. V.
10.1101/2021.06.09.447804 — neuroscience — Posted on 2021-06-10
2698 BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoids
Notaras, M.; Lodhi, A.; Dundar, F.; Collier, P.; Sayles, N.; Tilgner, H.; Greening, D.; Colak, D.
10.1101/2021.06.10.447949 — neuroscience — Posted on 2021-06-10
2699 Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum
Chipman, P. H.; Pazo Fernandez, A.; Fung, C. C. A.; Tedoldi, A.; Kawai, A.; Ghimire Gautam, S.; Kurosawa, M.; Abe, M.; Sakimura, K.; Fukai, T.; Goda, Y.
10.1101/2021.05.28.446253 — neuroscience — Posted on 2021-06-10
2702 Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids
Ambroggio, E. E.; Costa Navarro, G. S.; Perez Socas, L. B.; Bagatolli, L. A.; Gamarnik, A. V.
10.1101/2021.06.07.447421 — biophysics — Posted on 2021-06-10
2705 Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation induced tissue damage
Rognoni, E.; Goss, G.; Hiratsuka, T.; Kober, K. I.; Lui, P. P.; Tsang, V. S.; Hawkshaw, N.; Pilkington, S. M.; Sipilä, K.; Cho, I.; Ali, N.; Rhodes, L. E.; Watt, F. M.
10.1101/2021.06.08.447606 — cell biology — Posted on 2021-06-10
2707 Aspergillus fumigatus acetate utilisation impacts virulence traits and pathogenicity
Ries, L. N.; de Castro, P. A.; Silva, L. P.; Valero, C.; dos Reis, T. F.; Saborano, R.; Duarte, I. F.; Persinoti, G. F.; Steenwyk, J. L.; Rokas, A.; Almeida, F.; Costa, J. H.; Fill, T. P.; Sze Wah Wong, S.; Aimanianda, V.; Rodrigues, F.; Goncales, R. A.; Duarte-Oliveira, C.; Carvalho, A.; Goldman, G. H.
10.1101/2021.06.09.447827 — microbiology — Posted on 2021-06-10
2708 Identification of novel human derived influenza viruses in pigs with zoonotic potential.
tapia, r.; Brito, B.; Saavedra, M.; mena, j.; Garcia-Salum, T.; Rathnasinghe, R.; Barriga, G.; Tapia, K.; Garcia, V.; Bucarey, S.; Jang, Y.; Wentworth, D. E.; Torremorell, M.; Neira-Ramirez, V.; Medina, R. A.
10.1101/2021.06.08.447649 — microbiology — Posted on 2021-06-10
2709 Meditation-induced effects on whole-brain structural and effective connectivity
De Filippi, E.; Escrichs, A.; Gilson, M.; Sanchez-Fibla, M.; Camara, E.; Deco, G.; Garrido, C.
10.1101/2021.06.10.447903 — neuroscience — Posted on 2021-06-10
2710 Associative learning drives longitudinally-graded presynaptic plasticity of neurotransmitter release along axonal compartments
Stahl, A.; Noyes, N. C.; Boto, T.; Jing, M.; Zeng, J.; King, L. B.; Li, Y.; Davis, R. L.; Tomchik, S. M.
10.1101/2021.06.08.447536 — neuroscience — Posted on 2021-06-10
2712 Time-resolved secretome analysis of three Colletotrichum species identifies copper radical alcohol oxidases for the production of fatty aldehydes
Ribeaucourt, D.; Saker, S.; Navarro, D.; Bissaro, B.; Drula, E.; Oliveira Correia, L.; Haon, M.; Grisel, S.; Lapalu, N.; Henrissat, B.; O'Connell, R. J.; Lambert, F.; Lafond, M.; Berrin, J.-G.
10.1101/2021.06.09.447826 — biochemistry — Posted on 2021-06-10
2717 Variability in white matter structure relates to hallucination proneness
Johnson, J. F.; Schwartze, M.; Belyk, M.; Pinheiro, A. P.; Kotz, S. A.
10.1101/2021.06.10.447901 — neuroscience — Posted on 2021-06-10
2720 Rpi-amr3 confers resistance to multiple Phytophthora species by recognizing a conserved RXLR effector
Lin, X.; Olave-Achury, A.; Heal, R.; Witek, K.; Karki, H. S.; Song, T.; Wu, C.-h.; Adachi, H.; Kamoun, S.; Vleeshouwers, V. G. A. A.; Jones, J. D.
10.1101/2021.06.10.447899 — plant biology — Posted on 2021-06-10
2721 A chemical strategy toward novel brain-penetrant EZH2 inhibitors
Liang, R.; Tomita, D.; Sasaki, Y.; Ginn, J.; Michino, M.; Huggins, D. J.; Baxt, L.; Kargman, S.; Shahid, M.; Aso, K.; Duggan, M.; Stamford, A. W.; DeStanchina, E.; Liverton, N.; Meinke, P. T.; Foley, M. A.; Phillips, R. E.
10.1101/2021.06.10.447852 — cancer biology — Posted on 2021-06-10
2726 A community-driven roadmap to advance research on translated open reading frames detected by Ribo-seq
Mudge, J. M.; Ruiz-Orera, J.; Prensner, J. R.; Brunet, M. A.; Gonzalez, J. M.; Magrane, M.; Martinez, T.; Schulz, J. F.; Yang, Y. T.; Alba, M. M.; Baranov, P. V.; Bazzini, A.; Bruford, E.; Martin, M. J.; Carvunis, A.-R.; Chen, J.; Couso, J. P.; Flicek, P.; Frankish, A.; Gerstein, M.; Hubner, N.; Ingolia, N. T.; Menschaert, G.; Ohler, U.; Roucou, X.; Saghatelian, A.; Weissman, J.; van Heesch, S.
10.1101/2021.06.10.447896 — genomics — Posted on 2021-06-10
2730 Equine intestinal O-seroconverting temperate coliphage Hf4s: genomic and biological characterization
Kulikov, E. E.; Golomidova, A. K.; Efimov, A. D.; Belalov, I. S.; Letarova, M. A.; Zdorovenko, E. L.; Knirel, Y.; Dmitrenok, A.; Letarov, A. V.
10.1101/2021.06.09.447823 — microbiology — Posted on 2021-06-10
2736 HAUSP Stabilizes SOX2 through Deubiquitination to Maintain Self-renewal and Tumorigenic Potential of Glioma Stem Cells
Huang, Z.; Zhai, K.; Wu, Q.; Fang, X.; Huang, Q.; Tao, W.; Lathia, J. D.; Yu, J. S.; Rich, J. N.; Bao, S.
10.1101/2021.06.09.447550 — cancer biology — Posted on 2021-06-10
2740 Molecular dissection of pro-fibrotic signaling identifies the mechanism underlying IL11-driven fibrosis gene translation, reveals non-specific effects of STAT3 and suggests a new mechanism of action for nintedanib
Widjaja, A. A.; Viswanathan, S.; Dong, J.; Singh, B. K.; Tan, J.; Goh, J. W. T.; Lamb, D.; Shekeran, S. G.; George, B. L.; Schafer, S.; Carling, D.; Adami, E.; Cook, S. A.
10.1101/2021.06.10.447846 — molecular biology — Posted on 2021-06-10
2746 Thermodynamic genome-scale metabolic modeling of metallodrug resistance in colorectal cancer
Herrmann, H. A.; Rusz, M.; Baier, D.; Jakupec, M. A.; Keppler, B. K.; Berger, W.; Koellensperger, G.; Zanghellini, J.
10.1101/2021.06.09.447534 — cancer biology — Posted on 2021-06-10
2752 Salvage of Ribose from Uridine or RNA Supports Glycolysis when Glucose is Limiting
Jourdain, A. A.; Skinner, O. S.; Kawakami, A.; Goodman, R. P.; Shen, H.; Kemeny, L. V.; Joesch-Cohen, L.; Rees, M. G.; Roth, J. A.; Fisher, D. E.; Mootha, V. K.
10.1101/2021.06.10.447789 — biochemistry — Posted on 2021-06-10
2753 Most primary olfactory neurons have individually neutral effects on behavior
Tumkaya, T.; Burhanudin, S.; Khalilnezhad, A.; Stewart, J.; Choi, H.; Claridge-Chang, A.
10.1101/2021.06.10.447838 — animal behavior and cognition — Posted on 2021-06-10
2754 Desmosomal connectomics of all somatic muscles in an annelid larva
Jasek, S.; Veraszto, C.; Brodrick, E.; Shahidi, R.; Kazimiers, T.; Jekely, G.
10.1101/2021.06.09.447732 — animal behavior and cognition — Posted on 2021-06-10
2755 The Epiallelic Nature of Mouse rDNA
Rodriguez-Algarra, F.; Danson, A.; Seaborne, R.; Ylidizoglu, S.; Yoshikawa, H.; Law, P.; Ahmad, Z.; Maudsley, V.; Brew, A.; Holmes, N.; Hodgkinson, A.; Marzi, S.; Madapura, P.; Loose, M. W.; Holland, M.; Rakyan, V.
10.1101/2021.06.10.447887 — genomics — Posted on 2021-06-10
2756 Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome
Kaiser, V. B.; Talmane, L.; Kumar, Y.; Semple, F.; MacLennan, M.; FitzPatrick, D. R.; Taylor, M. S.; Semple, C. A.
10.1101/2021.06.10.447556 — genomics — Posted on 2021-06-10
2757 Induce Pluripotency via Specific distal enhancer-promoter associations
Zhu, X.; Huang, L.; Li, D.; Luo, J.; Huang, Q.; Wang, X.; Zhang, Y.
10.1101/2021.06.09.447809 — genomics — Posted on 2021-06-10
2767 A high content microscopy screening identifies genes involved in cell width control in Bacillus subtilis
Juillot, D.; Cornilleau, C.; Deboosere, N.; Billaudeau, C.; Evouna-Mengue, P.; Lejard, V.; Brodin, P.; Carballido-Lopez, R.; Chastanet, A.
10.1101/2021.06.10.444761 — microbiology — Posted on 2021-06-10
2771 pySuStaIn: a Python implementation of the Subtype and Stage Inference algorithm
Aksman, L. M.; Wijeratne, P. A.; Oxtoby, N. P.; Eshaghi, A.; Shand, C.; Altmann, A.; Alexander, D. C.; Young, A. L.
10.1101/2021.06.09.447713 — neuroscience — Posted on 2021-06-10
2774 CREB repressor in mushroom body enhances Drosophila LTM formation
Chiang, A.-S.; Chen, C.-C.; Lin, H.-W.; Feng, K.-L.; Jhang, R.-Y.; Chen, L.; de Belle, J. S.; Tully, T.
10.1101/2021.06.10.447902 — neuroscience — Posted on 2021-06-10
2775 Toward a More Accurate 3D Atlas of C. elegans Neurons
SKUHERSKY, M.; Wu, T.; Yemini, E.; Boyden, E.; Tegmark, M.
10.1101/2021.06.09.447813 — neuroscience — Posted on 2021-06-10
2778 MicroMator: Open and Flexible Software for Reactive Microscopy
Fox, Z. R.; Fletcher, S.; Fraisse, A.; Aditya, C.; Sosa-Carrillo, S.; Gilles, S.; Bertaux, F.; Ruess, J.; Batt, G.
10.1101/2021.03.12.435206 — systems biology — Posted on 2021-06-10
2779 Systems analysis reveals ageing-related perturbations in retinoids and sex hormones in Alzheimer's and Parkinson's diseases
Lam, S.; Hartmann, N.; Benfeitas, R.; Zhang, C.; Arif, M.; Turkez, H.; Uhlen, M.; Englert, C.; Knight, R. D.; Mardinoglu, A.
10.1101/2021.06.10.447367 — systems biology — Posted on 2021-06-10
2780 Scalable and Automated CRISPR-Based Strain Engineering Using Droplet Microfluidics
Iwai, K.; Wehrs, M.; Garber, M.; Sustarich, J.; Washburn, L.; Costello, Z.; Kim, P. W.; Ando, D.; Gaillard, W. R.; Hillson, N. J.; Adams, P. D.; Mukhopadhyay, A.; Martin, H. G.; Singh, A. K.
10.1101/2021.06.10.447396 — synthetic biology — Posted on 2021-06-10
2782 Calcium-permeable cation channels are involved in uranium uptake in Arabidopsis thaliana
Sarthou, M.; Devime, F.; Baggio, C.; Figuet, S.; ALBAN, C.; Bourguignon, J.; Ravanel, S.
10.1101/2021.06.10.447834 — plant biology — Posted on 2021-06-10
2783 Underwater CAM photosynthesis elucidated by Isoetes genome
Wickell, D.; Kuo, L.-Y.; Yang, H.-P.; Ashok, A. D.; Irisarri, I.; Dadras, A.; de Vries, S.; de Vries, J.; Huang, Y.-M.; Li, Z.; Barker, M. S.; Hartwick, N. T.; Michael, T. P.; Li, F.-W.
10.1101/2021.06.09.447806 — plant biology — Posted on 2021-06-10
2784 A robust field-based method to screen heat tolerance in wheat
Ullah, N.; Christopher, J.; FREDERIKS, T.; Ma, S.; Tan, D.; Chenu, K.
10.1101/2021.06.09.447803 — plant biology — Posted on 2021-06-10
2786 Phenotyping the tumor-immune microenvironment (TiME) in vivo by cellular-level optical imaging reveals unique combination phenotypes with variable inflammation and endothelial anergy
Sahu, A.; Tembo, T.; Kose, K.; Santella, A.; Alfonso, A.; Li, M.; Cordova, M.; Gill, M.; Fox, C.; Gonzalez, S.; Wang, A. W.; Kurtansky, N. R.; Chandrani, P.; Kumar, P.; Yin, S.; Jilani, H.; Mehta, P.; Navarrete-Dechent, C.; Peterson, G.; King, K.; Dusza, S.; Yang, N.; Liu, S.; Phillip, W.; Rossi, A.; Halpern, A.; Deng, L.; Pulitzer, M.; Marghoob, A.; Chen, C.-S. J.; Rajadhyaksha, M.
10.1101/2021.06.10.447835 — cancer biology — Posted on 2021-06-10
2787 Anti-GD2 antibody therapy alters the neuroblastoma tumor microenvironment and extends survival in TH-MYCN mice
McNerney, K. O.; Karageorgos, S.; Ferry, G.; Wolpaw, A.; Burudpakdee, C.; Khurana, P.; Vemu, R.; Vu, A.; Hogarty, M. D.; Bassiri, H.
10.1101/2021.06.09.447746 — cancer biology — Posted on 2021-06-10
2789 CANT-HYD: A curated database of phylogeny-derived Hidden Markov Models for annotation of marker genes involved in hydrocarbon degradation
Khot, V.; Zorz, J.; Gittins, D. A.; Chakraborty, A.; Bell, E.; Bautista, M. A.; Paquette, A. J.; Hawley, A. K.; Novotnik, B.; Hubert, C. R. J.; Strous, M.; Bhatnagar, S.
10.1101/2021.06.10.447808 — bioinformatics — Posted on 2021-06-10
2791 SignalP 6.0 achieves signal peptide prediction across all types using protein language models
Teufel, F.; Armenteros, J. J. A.; Johansen, A. R.; Gislason, M. H.; Pihl, S. I.; Tsirigos, K. D.; Winther, O.; Brunak, S.; Von Heijne, G.; Nielsen, H.
10.1101/2021.06.09.447770 — bioinformatics — Posted on 2021-06-10
2796 Segmentation of Pancreatic Ductal Adenocarcinoma (PDAC) and surrounding vessels in CT images using deep convolutional neural networks and Texture Descriptors
Mahmoudi, T.; Mousavi Kouzehkanan, Z.; Radmard, A.; Kafieh, R.; Salehnia, A.; Davarpanah, A. H.; Arabalibeik, H.; Ahmadian, A.
10.1101/2021.06.09.447508 — bioengineering — Posted on 2021-06-10
2798 BacPROTACs mediate targeted protein degradation in bacteria
Morreale, F. E.; Kleine, S.; Leodolter, J.; Ovchinnikov, S.; Kley, J.; Kurzbauer, R.; Hoi, D. M.; Meinhart, A.; Hartl, M.; Haselbach, D.; Kaiser, M.; Clausen, T.
10.1101/2021.06.09.447781 — biochemistry — Posted on 2021-06-10
2799 Ghrelin proteolysis by insulin-degrading enzyme
Bocach, D. D.; Jones, K. L.; Bell, J. M.; Zheng, Q.; Lazo, N. D.; Smith-Carpenter, J. E.; Alper, B. J.
10.1101/2021.06.10.447714 — biochemistry — Posted on 2021-06-10
2800 Indigenous ancestry and admixture in the Uruguayan population
Spangenberg, L.; Fariello, M. I.; Arce, D.; Illanes, G.; Greif, G.; Shin, J.-Y.; Yoo, S.-K.; Seo, J.-S.; Robello, C.; Kim, C.; Novembre, J.; Sans, M.; Naya, H.
10.1101/2021.06.09.447750 — genomics — Posted on 2021-06-10
2804 Impact of SNP calling quality on the detection of transmission ratio distortion in goats
Luigi-Sierra, M.; Casellas, J.; Martinez, A.; Delgado, J. V.; Alvarez, J. F.; Such, F. X.; Jordana, J.; Amills, M.
10.1101/2021.06.09.447792 — genetics — Posted on 2021-06-10
2805 Genetic analysis of praziquantel resistance in schistosome parasites implicates a Transient Receptor Potential channel
Le Clec'h, W.; Chevalier, F. D.; Mattos, A. C. A.; Strickland, A.; Diaz, R.; McDew-White, M.; Rohr, C. M.; Kinung'hi, S.; Allan, F.; Webster, B. L.; Webster, J. P.; Emery, A. M.; Rollinson, D.; Garba Djirmay, A.; Al Mashikhi, K. M.; Al Yafae, S.; Idris, M. A.; Mone, H.; Mouahid, G.; LoVerde, P.; Marchant, J.; Anderson, T. J. C.
10.1101/2021.06.09.447779 — genetics — Posted on 2021-06-10
2811 Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism
Rao, Q.; Wang, Y.; Chai, P.; Han, L.; Kuo, Y.-W.; Yang, R.; Hu, F.; Yang, Y.; Howard, J.; Zhang, K.
10.1101/2020.12.08.415687 — cell biology — Posted on 2021-06-10
2813 Amyloid aggregation of Streptococcus mutans Cnm influences its collagen-binding activity
de Mojana di Cologna, N.; Samaddar, S.; Valle, C.; Vargas, J. A.; Aviles-Reyes, A.; Morales, J.; Ganguly, T.; Pileggi, R.; Brady, L. J.; Lemos, J. A.; Abranches, J.
10.1101/2021.06.09.447825 — microbiology — Posted on 2021-06-10
2815 Enteric glial cells favour accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation
Stakenborg, M.; Abdurahiman, S.; De Simone, V.; Goverse, G.; Stakenborg, N.; Van Baarle, L.; Wu, Q.; Pirottin, D.; Kim, J.-S.; Maor, L.; Pintelon, I.; Thys, S.; Boon, L.; Hao, M.; Van Ginderachter, J.; Boeckxstaens, G. E.; Timmermans, J.-P.; Jung, S.; Marichal, T.; Ibiza, S.; Matteoli, G.
10.1101/2021.06.10.447700 — immunology — Posted on 2021-06-10
2818 Open multimodal iEEG-fMRI dataset from naturalistic stimulation with a short audiovisual film
Berezutskaya, J.; Vansteensel, M. J.; Aarnoutse, E. J.; Freudenburg, Z. V.; Piantoni, G.; Branco, M. P.; Ramsey, N. F.
10.1101/2021.06.09.447733 — neuroscience — Posted on 2021-06-10
2819 Molecular characterization of AMPA receptor trafficking vesicles
Peters, J. J.; Leitz, J.; Oses-Prieto, J. A.; Burlingame, A. L.; Brunger, A. T.
10.1101/2021.06.09.447771 — neuroscience — Posted on 2021-06-10
2820 Clock time: a foreign measure to brain dynamics
van Bree, S.; Melcon, M.; Kolibius, L.; Kerren, C.; Wimber, M.; Hanslmayr, S.
10.1101/2021.06.09.447763 — neuroscience — Posted on 2021-06-10
2821 Geometry of inter-areal interactions in mouse visual cortex
Iyer, R.; Siegle, J. H.; Mahalingam, G.; Olsen, S.; Mihalas, S.
10.1101/2021.06.09.447638 — neuroscience — Posted on 2021-06-10
2822 Normal Aging in Mice is Associated with a Global Reduction in Cortical Spectral Power and a Network-Specific Decline in Functional Connectivity
Albertson, A. J.; Landsness, E. C.; Tang, M. J.; Yan, P.; Miao, H.; Rosenthal, Z. P.; Kim, B.; Culver, J. C.; Bauer, A. Q.; Lee, J.-M.
10.1101/2021.06.09.447772 — neuroscience — Posted on 2021-06-10
2824 Transcriptomic similarities and differences between mouse models and human Alzheimer's Disease
De Bastiani, M. A.; Bellaver, B.; Collar, G.; Forner, S.; Martini, A. C.; Pascoal, T.; Zimmer, E.
10.1101/2021.06.09.447404 — neuroscience — Posted on 2021-06-10
2826 Placental polyamines regulate acetyl-coA and histone acetylation in a sex-dependent manner
Aye, I. L. M. H.; Gong, S.; Avellino, G.; Barbagallo, R.; Gaccioli, F.; Jenkins, B.; Koulman, A.; Murray, A. J.; Charnock-Jones, D. S.; Smith, G. C. S.
10.1101/2021.06.09.447192 — physiology — Posted on 2021-06-10
2828 An Unsupervised Graph Embeddings Approach to Multiplex Immunofluorescence Image Exploration
Innocenti, C.; Zhang, Z.; Selvaraj, B.; Gaffney, I.; Frangos, M.; Cohen-Setton, J.; Dillon, L. A. L.; Surace, M. J.; Pedrinaci, C.; Hipp, J.; Baykaner, K.
10.1101/2021.06.09.447654 — pathology — Posted on 2021-06-10
2830 Emerging single cell endothelial heterogeneity supports sprouting tumour angiogenesis and growth
Gerhardt, H.; Matsumoto, K.; Rambow, F.; Stanchi, F.; Mathivet, T.; Qian, J.; Giese, W.; He, L.; Lambrechts, D.; Zhou, B.; Betsholtz, C.; Marine, J.-C.
10.1101/2021.06.09.447719 — cancer biology — Posted on 2021-06-10
2832 Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor
Wang, Y.; Guo, S.; Zhuang, Y.; Yun, Y.; Xu, P.; He, X.; Guo, J.; Yin, W.; Xu, H. E.; Xie, X.; Jiang, Y.
10.1101/2021.06.09.447478 — biophysics — Posted on 2021-06-10
2835 Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2
Wang, X.; Cheng, X.; Zhao, L.; Wang, Y.; Ye, C.; Zou, X.; Dai, A.; Cong, Z.; Chen, J.; Zhou, Q.; Xia, T.; Jiang, H.; Xu, H. E.; Yang, D.; Wang, M.-W.
10.1101/2021.06.09.447485 — biochemistry — Posted on 2021-06-10
2837 Landscape and climatic variations of the Quaternary shaped multiple secondary contacts among barn owls (Tyto alba) of the Western Palearctic
Cumer, T.; Machado, A. P.; Dumont, G.; Bontzorlos, V.; Ceccherelli, R.; Charter, M.; Dichmann, K.; Martens, H.-D.; Kassinis, N.; Lourenco, R.; Manzia, F.; Prevost, L.; Rakovic, M.; Siverio, F.; Roulin, A.; Goudet, J.
10.1101/2021.06.09.447652 — evolutionary biology — Posted on 2021-06-10
2838 Bee foraging preferences, microbiota and pathogens revealed by direct shotgun metagenomics of honey
Galanis, A.; Vardakas, P.; Reczko, M.; Harokopos, V.; Hatzis, P.; Skoulakis, E. M. C.; Pavlopoulos, G. A.; Patalano, S.
10.1101/2021.06.09.447678 — ecology — Posted on 2021-06-10
2840 Habitat Protection Indexes - new monitoring measures for the conservation of coastal and marine habitats
Kumagai, J. A.; Favoretto, F.; Pruckner, S.; Rogers, A. D.; Weatherdon, L. V.; Aburto-Oropeza, O.; Niamir, A.
10.1101/2021.06.09.447318 — ecology — Posted on 2021-06-10
2842 Typical resting state activity of the brain requires visual input during an early sensitive period
Raczy, K.; Hölig, C.; Guerreiro, M. J. S.; Lingareddy, S.; Kekunnaya, R.; Röder, B.
10.1101/2021.06.09.446724 — neuroscience — Posted on 2021-06-10
2843 Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus
Tsoi, S. Y.; Öncül, M.; Svahn, E.; Robertson, M.; Bogdanowicz, Z.; McClure, C.; Sürmeli, G.
10.1101/2021.03.10.434566 — neuroscience — Posted on 2021-06-10
2844 Interpersonal synchronization of movement intermittency
Tomassini, A.; Laroche, J.; Emanuele, M.; Nazzaro, G.; Petrone, N.; Fadiga, L.; D'Ausilio, A.
10.1101/2021.06.09.447663 — neuroscience — Posted on 2021-06-10
2845 Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves
Backhausen, L. L.; Froehner, J. H.; Lemaitre, H.; Artiges, E.; Paillere-Martinot, M.-L.; Herting, M. M.; Sticca, F.; Banaschewski, T.; Barker, G. J.; Bokde, A. L. W.; Desrivieres, S.; Flor, H.; Grigis, A.; Garavan, H.; Gowland, P.; Heinz, A.; Bruehl, R.; Nees, F.; Papadopoulos-Orfanos, D.; Poustka, L.; Hohmann, S.; Robinson, L.; Walter, H.; Winterer, J.; Whelan, R.; Schumann, G.; Martinot, J.-L.; Smolka, M. N.; Vetter, N. C.; IMAGEN Consortium,
10.1101/2021.06.09.447677 — neuroscience — Posted on 2021-06-10
2847 Frontal cortical functional connectivity is impacted by anaesthesia in macaques
Giacometti, C.; Dureux, A.; Autran-Clavagnier, D.; Wilson, C. C. R. E.; Sallet, J.; Dirheimer, M.; Procyk, E.; Hadj-Bouziane, F.; Amiez, C.
10.1101/2021.06.09.447698 — neuroscience — Posted on 2021-06-10
2852 Integrative Epigenomic and High-Throughput Functional Enhancer Profiling Reveals Determinants of Enhancer Heterogeneity in Gastric Cancer
Sheng, T.; Ho, S. W. T.; Ooi, W. F.; Xu, C.; Xing, M.; Padmanabhan, N.; Huang, K. K.; Ma, L.; Ray, M.; Guo, Y. A.; Leng, S. N.; Anene-Nzelu, C. G.; Chang, M. M.; Razavi-Mohseni, M.; Beer, M.; Foo, R.; Tan, A. L. K.; Ong, X.; Jacobsen Skanderup, A.; White, K. P.; Jha, S.; Tan, P.
10.1101/2021.06.09.447637 — cancer biology — Posted on 2021-06-10
2853 Discovering fragment length signatures of circulating tumor DNA using Non-negative Matrix Factorization
Renaud, G.; Noergaard, M.; Lindberg, J.; Groenberg, H.; De Laere, B.; Jensen, J. B.; Borre, M.; Andersen, C. L.; Soerensen, K. D.; Maretty, L.; Besenbacher, S.
10.1101/2021.06.09.447533 — bioinformatics — Posted on 2021-06-10
2855 Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models
Chourrout, M.; Rositi, H.; Ong, E.; Hubert, V.; Paccalet, A.; Foucault, L.; Autret, A.; Fayard, B.; Olivier, C.; Bolbos, R.; Peyrin, F.; Crola Da Silva, C.; Meyronet, D.; Raineteau, O.; Elleaume, H.; Brun, E.; Chauveau, F.; Wiart, M.
10.1101/2021.03.24.436852 — neuroscience — Posted on 2021-06-10
2859 An outbreak of SARS-CoV-2 with high mortality in mink (Neovison vison) on multiple Utah farms
Eckstrand, C.; Baldwin, T.; Torchetti, M. K.; Killian, M. L.; Rood, K. A.; Clayton, M.; Lott, J. A.; Wolking, R. M.; Bradway, D. S.; Baszler, T.
10.1101/2021.06.09.447754 — microbiology — Posted on 2021-06-10
2861 Brain charts for the human lifespan
Bethlehem, R. A. I.; Seidlitz, J.; White, S. R.; Vogel, J. W.; Anderson, K. M.; Adamson, C.; Adler, S.; Alexopoulos, G. S.; Anagnostou, E.; Areces-Gonzalez, A.; Astle, D. E.; Auyeung, B.; Ayub, M.; Ball, G.; Baron-Cohen, S.; Beare, R.; Bedford, S. A.; Benegal, V.; Beyer, F.; Bin Bae, J.; Blangero, J.; Blesa Cabez, M.; Boardman, J. P.; Borzage, M.; Bosch-Bayard, J. F.; Bourke, N.; Calhoun, V. D.; Chakravarty, M. M.; Chen, C.; Chertavian, C.; Chetelat, G.; Chong, Y. S.; Cole, J. H.; Corvin, A.; Courchesne, E.; Crivello, F.; Cropley, V. L.; Crosbie, J.; Crossley, N.; Delarue, M.; Desrivieres, S.;
10.1101/2021.06.08.447489 — neuroscience — Posted on 2021-06-10
2863 The openCARP Simulation Environment for Cardiac Electrophysiology
Plank, G.; Loewe, A.; Neic, A.; Augustin, C.; Huang, Y.-L.; Gsell, M. A. F.; Karabelas, E.; Nothstein, M.; Sanchez, J.; Prassl, A. J.; Seemann, G.; Vigmond, E. J.
10.1101/2021.03.01.433036 — bioinformatics — Posted on 2021-06-10
2866 Evolution of flowering time in a selfing annual plant: Roles of adaptation and genetic drift
Gay, L.; Dhinaut, J.; Jullien, M.; Vitalis, R.; Navascues, M.; Ranwez, V.; Ronfort, J.
10.1101/2020.08.21.261230 — evolutionary biology — Posted on 2021-06-10
2867 Informing shigellosis prevention and control through pathogen genomics
Bengtsson, R. J.; Simpkin, A. J.; Pulford, C. V.; Low, R.; Rasko, D. A.; Rigden, D. J.; Hall, N.; Barry, E. M.; Tennant, S. M.; Baker, K. S.
10.1101/2021.06.09.447709 — microbiology — Posted on 2021-06-10
2868 Characterisation of the symbionts in the Mediterranean fruitfly gut
Darrington, M.; Leftwich, P. T.; Holmes, N. A.; Friend, L. A.; Clarke, N. V. E.; Worsley, S. F.; Margaritopoulos, J. T.; Hogenhout, S. A.; Hutchings, M. I.; Chapman, T.
10.1101/2021.06.09.447743 — evolutionary biology — Posted on 2021-06-10
2869 Neonicotinoid and pyrethroid combination: A tool to manage insecticide resistance in malaria vectors? Insights from experimental evolution
Gonse Zoh, M.; Bonneville, J.-M.; Tutagana, J.; Laporte, F.; Fodjo, B. K.; Mouhamadou, C. S.; Sadia, C.; McBeath, J.; Schmitt, F.; Horstmann, S.; Reynaud, S.; DAVID, J.-P.
10.1101/2021.06.09.447494 — evolutionary biology — Posted on 2021-06-10
2872 Biotic homogenisation in bird communities leads to large-scale changes in species associations
Rigal, S.; Devictor, V.; Gaüzere, P.; Kefi, S.; Forsman, J. T.; Kajanus, M. H.; Mönkkönen, M.; Dakos, V.
10.1101/2020.11.13.380956 — ecology — Posted on 2021-06-10
2876 A novel auxin-inducible degron system for rapid, cell cycle-specific targeted proteolysis
Capece, M.; Tessari, A.; Mills, J.; Rampioni Vinciguerra, G. L.; Liu, C.; McElwain, B.; miles, w.; COPPOLA, V.; Palmieri, D.; Croce, C.
10.1101/2021.04.23.441203 — synthetic biology — Posted on 2021-06-09
2877 Genomic and Metabolic Hallmarks of SDH- and FH-Deficient Renal Cell Carcinomas
Yoo, A.; Tang, C.; Zucker, M.; Fitzgerald, K.; Rappold, P. M.; Weiss, K.; Freeman, B.; Lee, C.-H.; Schultz, N.; Motzer, R.; Russo, P.; Coleman, J.; Reuter, V. E.; Chen, Y.-B.; Carlo, M. I.; Gill, A. J.; Kotecha, R. R.; Hakimi, A. A.; Reznik, E.
10.1101/2021.06.09.445990 — cancer biology — Posted on 2021-06-09
2878 Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes
Huber, S. T.; Sarajlic, E.; Huijink, R.; Weis, F.; Evers, W. H.; Jakobi, A. J.
10.1101/2021.05.25.444805 — biophysics — Posted on 2021-06-09
2879 Myofilament Glycation in Diabetes Reduces Contractility by Inhibiting Tropomyosin Movement, is Rescued by cMyBPC Domains
Papadaki, M.; Kampaengsri, T.; Barrick, S. K.; Campbell, S. A.; Harris, S. P.; Greenberg, M. J.; Kirk, J. A.
10.1101/2021.06.09.447778 — biophysics — Posted on 2021-06-09
2880 Formation, collective motion, and merging of macroscopicbacterial aggregates
Boedicker, J. Q.; Courcoutbetis, G.; Gangan, M.; Lim, S.; Guo, X.; Haas, S.
10.1101/2021.06.09.447728 — biophysics — Posted on 2021-06-09
2881 Deciphering conformational selectivity in the A2A adenosine G protein-coupled receptor by Free Energy simulations
Gutierrez de Teran, H.; Jespers, W.; Heitman, L. H.; IJzerman, A. P.; Sotelo, E.; van Westen, G. J. P.; Aqvist, J.
10.1101/2021.06.09.447724 — biophysics — Posted on 2021-06-09
2883 Towards the prediction of non-peptidic epitopes
Zierep, P. F.; Vita, R.; Blazeska, N.; Greenbaum, J. A.; Peters, B.; Günther, S.
10.1101/2021.06.09.447727 — bioinformatics — Posted on 2021-06-09
2886 Postnatal activation of hypoxia pathway disrupts β-cell functional maturation
Yang, J.; Hammoud, B.; Ridler, A.; Ackermann, A. M.; Won, K.-J.; Hoshi, T.; Stanley, C. A.; Stanescu, D. E.
10.1101/2021.06.09.447705 — developmental biology — Posted on 2021-06-09
2887 Caveolae, CAVIN1, and lipid peroxidation mediate the oxidative stress response
Wu, Y.; Lim, Y.-W.; Stroud, D. A.; Martel, N.; Hall, T. E.; Lo, H.; Ferguson, C.; Ryan, M. T.; McMahon, K.-A.; Parton, R. G.
10.1101/2021.06.09.447684 — cell biology — Posted on 2021-06-09
2888 A deep generative model of 3D single-cell organization
Donovan-Maiye, R.; Brown, J.; Chan, C.; Ding, L.; Yan, C.; Gaudreault, N.; Theriot, J.; Maleckar, M.; Knijnenburg, T.; Johnson, G.
10.1101/2021.06.09.447725 — cell biology — Posted on 2021-06-09
2889 Second Generation Antibodies Neutralize Emerging SARS-CoV-2 Variants of Concern
Kovacech, B.; Fialova, L.; Filipcik, P.; Zilkova, M.; Skrabana, R.; Paulenka-Ivanovova, N.; Kovac, A.; Palova, D.; Paulikova Rolkova, G.; Tomkova, K.; Turic Csokova, N.; Markova, K.; Skrabanova, M.; Sinska, K.; Basheer, N.; Majerova, P.; Hanes, J.; Parrak, V.; Prcina, M.; Cehlar, O.; Cente, M.; Piestansky, J.; Fresser, M.; Novak, M.; Slavikova, M.; Borsova, K.; Cabanova, V.; Brejova, B.; Vinar, T.; Nosek, J.; Klempa, B.; Zilka, N.; Kontsekova, E.
10.1101/2021.06.09.447527 — microbiology — Posted on 2021-06-09
2893 An alignment free approach confirms semantic properties of species proteomes
Starcevic, A.; Melvan, E.; Cvrljak, T.; Diminic, J.; Zucko, J.; Long, P. F.
10.1101/2021.06.04.447028 — systems biology — Posted on 2021-06-09
2894 Hematopoietic differentiation is characterized by a transient peak of cell-to-cell gene expression variability in normal and pathological conditions.
Dussiau, C.; Boussaroque, A.; Gaillard, M.; Bravetti, C.; Zaroili, L.; Knosp, C.; Friedrich, C.; Asquier, P.; Willems, L.; Quint, L.; Bouscary, D.; Fontenay, M.; Espinasse, T.; Plesa, A.; Sujobert, P.; Gandrillon, O.; Kosmider, O.
10.1101/2021.04.30.442092 — systems biology — Posted on 2021-06-09
2896 Teacher Perceptions of Using Robots to Teach Neuroscience in Secondary School
de Freitas, C. C. S.; Hanzlick-Burton, C.; Nestorovic, M.; DeBoer, J.; Gage, G. J.; Harris, C. A.
10.1101/2021.04.01.438071 — scientific communication and education — Posted on 2021-06-09
2897 Dietary intervention improves health metrics and life expectancy of the genetically obese DU6 (Titan) mouse
Mueller-Eigner, A.; Sanz-Moreno, A.; de-Diego, I.; Venkateswaran Venkatasubramani, A.; Langhammer, M.; Gerlini, R.; Rathkolb, B.; Aguilar-Pimentel, A.; Klein-Rodewald, T.; Calzada-Wack, J.; Becker, L.; Palma-Vera, S.; Gille, B.; Forne, I.; Imhof, A.; Meng, C.; Ludwig, C.; Koch, F.; Kuhla, A.; Caton, V.; Brenmoehl, J.; Schoen, J.; Fuchs, H.; Gailus-Durner, V.; Hoeflich, A.; Hrabe de Angelis, M.; Peleg, S.
10.1101/2020.05.11.088625 — physiology — Posted on 2021-06-09
2899 Targeted Delivery of Chloroquine to Plasmacytoid Dendritic Cells Enhances Inhibition of the Type I Interferon Response
Allen, M. E.; Golding, A.; Rus, V.; Karabin, N. B.; Li, S.; Lescott, C.; Bobbala, S.; Scott, E. A.; Szeto, G. L.
10.1101/2021.06.09.447773 — bioengineering — Posted on 2021-06-09
2901 Allele-specific gene editing rescues pathology in a human model of Charcot-Marie-Tooth disease type 2E
Feliciano, C. M.; Wu, K.; Watry, H. L.; Marley, C. B. E.; Ramadoss, G. N.; Ghanim, H. Y.; Liu, A. Z.; Zholudeva, L. V.; McDevitt, T. C.; Saporta, M. A.; Conklin, B. R.; Judge, L. M.
10.1101/2021.06.09.447796 — genetics — Posted on 2021-06-09
2902 Natural selection promotes the evolution of recombination 2: during the selective process
Gerrish, P. J.; Cordero, F.; Galeota-Sprung, B.; Colato, A.; Vejalla, V.; Sniegowski, P. D.; Hengartner, N. W.
10.1101/2021.06.07.447324 — evolutionary biology — Posted on 2021-06-09
2903 Single cell chronoatlas of regenerating mouse livers reveals early Kupffer cell proliferation
Beldi, G.; Brodie, T.; Zindel, J.; Dommann, N.; Surewaard, B. G. J.; Keogh, A.; Melin, N.; Buechi, I.; Tombolini, R.; Candinas, D.; Sanchez-Taltavull, D.; Beldi, G.; Stroka, D.
10.1101/2021.06.09.447699 — developmental biology — Posted on 2021-06-09
2906 A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories
Sias, A. C.; Morse, A. K.; Wang, S.; Greenfield, V. Y.; Goodpaster, C. M.; Wrenn, T. M.; Wikenheiser, A. M.; Holley, S. M.; Cepeda, C.; Levine, M. S.; Wassum, K. M.
10.1101/2021.03.20.436233 — neuroscience — Posted on 2021-06-09
2912 Diversification of ergot alkaloids and heritable fungal symbionts in morning glories
Beaulieu, W. T.; Panaccione, D. G.; Quach, Q. N.; Miller, R. E.; Smoot, K. L.; Clay, K.
10.1101/2021.06.09.447740 — plant biology — Posted on 2021-06-09
2913 Endogenous RNA editing of a nuclear gene BOSS triggers flowering in tomato
Wang, W.; Ye, J.; Yu, C.; Xie, Q.; Wang, X.; Yu, H.; Song, J.; Li, C.; Cui, L.; Han, H.; Yang, C.; Li, H.; Lu, Y.; Wang, T.; Zhang, Y.; Zhang, J.; Ouyang, B.; Ye, Z.
10.1101/2021.06.09.447702 — plant biology — Posted on 2021-06-09
2914 Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival
Sousa, A.; Dugourd, A.; Memon, D.; Petursson, B.; Petsalaki, E.; Saez-Rodriguez, J.; Beltrao, P.
10.1101/2021.06.09.447741 — cancer biology — Posted on 2021-06-09
2917 Profiling site-specific cell states of Ewing Sarcoma xenografts in zebrafish
Segal, D.; Mazloom-Farsibaf, H.; Chang, B.-J.; Roudot, P.; Warren, M.; Fiolka, R.; Amatruda, J.; Danuser, G.
10.1101/2021.06.09.447621 — cancer biology — Posted on 2021-06-09
2919 SARS-CoV-2 B.1.617 Indian variants: are electrostatic potential changes responsible for a higher transmission rate?
Pascarella, S.; Ciccozzi, M.; Zella, D.; Bianchi, M.; Benedetti, F.; Broccolo, F.; Cauda, R.; Caruso, A.; Angeletti, S.; Giovanetti, M.; Cassone, A.
10.1101/2021.06.08.445535 — bioinformatics — Posted on 2021-06-09
2921 A dual allosteric pathway drives human mitochondrial Lon
Valentin Gese, G.; Shahzad, S.; Pardo-Hernandez, C.; Wramstedt, A.; Falkenberg, M.; Hällberg, B. M.
10.1101/2021.06.09.447696 — biochemistry — Posted on 2021-06-09
2924 Natural selection promotes the evolution of recombination 1: among selected genotypes
Gerrish, P. J.; Galeota-Sprung, B. J.; Sniegowski, P. D.; Chevallier, J.; Ycart, B.
10.1101/2021.06.07.447320 — evolutionary biology — Posted on 2021-06-09
2927 A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics
Steenkiste, E. M.; Berndt, J. D.; Pilling, C.; Simpkins, C.; Cooper, J. A.
10.1101/2021.01.29.428899 — cell biology — Posted on 2021-06-09
2929 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit
Rebelo-Guiomar, P.; Pellegrino, S.; Dent, K.; Sas- Chen, A.; Miller-Fleming, L.; Garone, C.; Van Haute, L.; Rogan, J. F.; Dinan, A. M.; Firth, A. E.; Andrews, B.; Whitworth, A. J.; Schwartz, S.; Warren, A. J.; Minczuk, M.
10.1101/2021.06.09.447755 — molecular biology — Posted on 2021-06-09
2930 Hepatocyte androgen receptor in females mediates androgen-induced hepatocellular glucose mishandling and systemic insulin resistance
Andrisse, S.; Feng, M.; Wang, Z.; Awe, O.; Yu, L.; Zhang, H.; Bi, S.; Wang, H.; Li, L.; Joseph, S.; Heller, N.; Mauvais-Jarvis, F.; Wong, G. W.; Segars, J.; Wolfe, A.; Divall, S.; Ahima, R.; Wu, S.
10.1101/2021.06.09.447759 — molecular biology — Posted on 2021-06-09
2931 Detection of Neisseria meningitidis in Saliva and Oropharyngeal Samples from College Students
Miellet, W.; Mariman, R.; Pluister, G.; de Jong, L. J.; Grift, I.; Wijkstra, S.; van Logchem, E.; van Veldhuizen, J.; Immink, M.-M.; Wijmenga-Monsuur, A. J.; Rots, N. Y.; Sanders, E. A.; Bosch, T.; Trzcinski, K.
10.1101/2021.06.09.447670 — microbiology — Posted on 2021-06-09
2932 Fungal succession on the decomposition of three plant species from a Brazilian mangrove
Moitinho, M. A.; Chiaramonte, J. B.; Bononi, L.; Gumiere, T.; Melo, I. S.; Taketani, R. G.
10.1101/2021.06.09.447690 — microbiology — Posted on 2021-06-09
2933 Informing shigellosis prevention and control through pathogen genomics
Bengtsson, R. J.; Baker, K. S.; Tennant, S. M.; Barry, E. M.; Hall, N.; Low, R.; Pulford, C. V.; Simpkin, A. J.; Rigden, D. J.; Rasko, D. A.
10.1101/2021.06.09.447709 — microbiology — Posted on 2021-06-09
2936 Neutralizing antibodies elicited by the Ad26.COV2.S COVID-19 vaccine show reduced activity against 501Y.V2 (B.1.351), despite protection against severe disease by this variant.
Moore, P.; Moyo, T.; Hermanus, T.; Kgagudi, P.; Ayres, F.; Makhado, Z.; Sadoff, J.; Le Gars, M.; van Roey, G.; Crowther, C.; Garrett, N.; Bekker, L.-G.; Morris, L.; Schuitemaker, H.; Gray, G.
10.1101/2021.06.09.447722 — immunology — Posted on 2021-06-09
2937 Oral subunit SARS-CoV-2 vaccine induces systemic neutralizing IgG, IgA and cellular immune responses and can boost neutralizing antibody responses primed by an injected vaccine
Pitcovski, J.; Gruzdev, N.; Abzach, A.; Katz, C.; Ben-Adiva, R.; Brand Schwartz, M.; Yadid, I.; Haviv, H.; Rapoport, I.; Bloch, I.; Shadmon, R.; Eitan, Z.; Eliyahu, D.; Hillel, T.; Laster, M.; Kremer Tal, S.; Byk Tennenbaum, T.; Shahar, E.
10.1101/2021.06.09.447656 — immunology — Posted on 2021-06-09
2939 The Impact of Neuronal Structure on Cortical Network Architecture
Udvary, D.; Harth, P.; Macke, J. H.; Hege, H.-C.; de Kock, C. P. J.; Sakmann, B.; Oberlaender, M.
10.1101/2020.11.13.381087 — neuroscience — Posted on 2021-06-09
2940 Komagataeibacter tool kit (KTK): a modular cloning system for multigene constructs and programmed protein secretion from cellulose producing bacteria
Goosens, V. J.; Walker, K. T.; Aragon, S. M.; Singh, A.; Senthivel, V. R.; Dekker, L.; Caro-Astorga, J.; Buat, M. L. A.; Song, W.; Lee, K.-y.; Ellis, T.
10.1101/2021.06.09.447691 — synthetic biology — Posted on 2021-06-09
2941 Measuring mitochondrial electron transfer complexes in previously frozen cardiac tissue from the offspring of sow: A model to assess exercise induced mitochondrial bioenergetics changes
Barrera, D.; Upton, S.; Rauch, M.; Notarianni, T.; Eum, K. S.; Liberty, M.; Liu, R.; Newcomer, S.; May, L. E.; Agbas, E.; Sage, J.; Kosa, E.; Agbas, A.
10.1101/2021.06.08.447578 — biochemistry — Posted on 2021-06-09
2947 Genomic Prediction of Strawberry Resistance to Postharvest Fruit Decay Caused by the Fungal Pathogen Botrytis cinerea
Knapp, S. J.; Blanco-Ulate, B.; Feldmann, M. J.; Pincot, D. D. A.; Cole, G. S.; Mesquida-Pesci, S. D.; Lopez Ramirez, C. M.; Famula, R. A.; Hardigan, M. A.
10.1101/2021.06.08.447540 — genetics — Posted on 2021-06-09
2948 The role of interference between vectors in control of plant diseases
Zaffaroni, M.; Rimbaud, L.; Mailleret, L.; Cunniffe, N.; Bevacqua, D.
10.1101/2021.06.08.447498 — ecology — Posted on 2021-06-09
2951 A habitat class to land cover translation model for mapping Area of Habitat of terrestrial vertebrates
Lumbierres, M.; Dahal, P. R.; Di Marco, M.; Butchart, S. H. M.; Donald, P. F.; Rondinini, C.
10.1101/2021.06.08.447053 — ecology — Posted on 2021-06-09
2953 Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of Elizabethkingia spp.
Yuan, S.; Chen, Y.; Song, Y.; Zou, L.; Lin, K.; Lu, X.; Liu, R.; Zhang, S.; Shen, D.; Song, Z.; Tong, C.; CHEN, L.; Sun, G.
10.1101/2021.06.08.447646 — microbiology — Posted on 2021-06-09
2955 Leveraging host-genetics and gut microbiota to determine immunocompetence in pigs
Ramayo-Caldas, Y.; Zingaretti, L. M.; Perez-Pascual, D.; Alexandre, P. A.; Reverter-Gomez, A.; Dalmau, A.; Quintanilla, R.; Ballester, M.
10.1101/2021.06.08.447584 — microbiology — Posted on 2021-06-09
2958 The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion
Dard, R. F.; Leprince, E.; Denis, J.; RAO-BALAPPA, S.; Lopez, C.; Giorgi-Kurz, M.; Szwagier, T.; Dumont, T.; Rouault, H.; Minlebaev, M.; Baude, A.; Cossart, R.; Picardo, M. A.
10.1101/2021.06.08.447542 — neuroscience — Posted on 2021-06-09
2959 Pulsation changes link to impaired glymphatic function in a mouse model of vascular cognitive impairment
Li, M.; Kitamura, A.; Beverley, J.; Koudelka, J.; Duncombe, J.; Platt, B.; Wiegand, U. K.; Carare, R. O.; Kalaria, R. N.; Iliff, J. J.; Horsburgh, K.
10.1101/2021.06.08.447375 — neuroscience — Posted on 2021-06-09
2960 Regulation of brain aging by neutral sphingomyelinase 2
Zhu, Z.; Quadri, Z.; Crivelli, S. M.; Elsherbini, A.; Zhang, L.; Tripathi, P.; Qin, H.; Roush, E.; Spassieva, S. D.; Nikolova-Karakashian, M.; McClintock, T. S.; Bieberich, E.
10.1101/2021.06.08.445892 — neuroscience — Posted on 2021-06-09
2965 TrackSOM: mapping immune response dynamics through sequential clustering of time- and disease-course single-cell cytometry data
Putri, G. H.; Chung, J.; Edwards, D. N.; Marsh-Wakefield, F.; Dervish, S.; Koprinska, I.; King, N. J.; Ashhurst, T. M.; Read, M. N.
10.1101/2021.06.08.447468 — bioinformatics — Posted on 2021-06-09
2969 The interactome of site-specifically acetylated linker histone H1
Hoellmueller, E.; Greiner, K.; Kienle, S. M.; Scheffner, M.; Marx, A.; Stengel, F.
10.1101/2021.06.08.447242 — biochemistry — Posted on 2021-06-09
2971 Nuclear-cytoplasmic balance: whole genome duplications induce elevated organellar genome copy number
Fernandes Gyorfy, M.; Miller, E. R.; Conover, J. L.; Grover, C. E.; Wendel, J. F.; Sloan, D. B.; Sharbrough, J.
10.1101/2021.06.08.447629 — evolutionary biology — Posted on 2021-06-09
2972 Tropical tree growth sensitivity to climate is driven by species intrinsic growth rate and leaf traits
Bauman, D.; Fortunel, C.; Cernusak, L. A.; Bentley, L. P.; McMahon, S. M.; Aguirre-Gutierrez, J.; Oliveras, I.; Bradford, M.; Laurance, S. G. W.; Delhaye, G.; Hutchinson, M. F.; Dempsey, R.; McNellis, B. E.; Santos-Andrade, P. E.; Ninantay-Rivera, H. R.; Chambi Paucar, J. R.; Phillips, O. L.; Malhi, Y.
10.1101/2021.06.08.447571 — ecology — Posted on 2021-06-09
2973 Microbial communities network structure across strong environmental gradients: How do they compare to macroorganisms?
Arboleda-Baena, C. M.; Freilich, M.; Pareja, C. B.; Logares, R.; De la Iglesia, R.; Navarrete, S.
10.1101/2021.06.08.445284 — ecology — Posted on 2021-06-09
2974 Biologging of emperor penguins - attachment techniques and associated deployment performance
Houstin, A.; Zitterbart, D. P.; Winterl, A.; Richter, S.; Planas-Bielsa, V.; Chevallier, D.; Ancel, A.; Fournier, J.; Fabry, B.; Le Bohec, C.
10.1101/2021.06.08.446548 — ecology — Posted on 2021-06-09
2976 DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging
Sepe, S.; Rossiello, F.; Cancila, V.; Iannelli, F.; Matti, V.; Cicio, G.; Cabrini, M.; Marinelli, E.; Alabi, B.; di Lillo, A.; Di Napoli, A.; Shay, J. W.; Tripodo, C.; d'Adda di Fagagna, F.
10.1101/2021.06.09.447484 — cell biology — Posted on 2021-06-09
2977 Monitoring group activity of hamsters and mice as a novel tool to evaluate COVID-19 progression, convalescence and rVSV-ΔG-spike vaccination efficacy
Melamed, S.; Politi, B.; Grauer, E.; Achdout, H.; Aftalion, M.; Gur, D.; Tamir, H.; Yahalom-Ronen, Y.; Maimon, S.; Yitzhak, E.; Weiss, S.; Rosner, A.; Erez, N.; Yitzhaki, S.; Shapira, S. C.; Paran, N.; Mamroud, E.; Vagima, Y.; Israely, T.
10.1101/2021.06.09.447687 — immunology — Posted on 2021-06-09
2980 Computational modeling of cell signaling and mutations in pancreatic cancer
Telmer, C. A.; Sayed, K.; Butchy, A. A.; Bocan, K.; Kaltenmeier, C.; Lotze, M. T.; Miskov-Zivanov, N.
10.1101/2021.06.08.447557 — systems biology — Posted on 2021-06-09
2981 The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology
Mejhert, N.; Gabriel, K. R.; Krahmer, N.; Kuruvilla, L.; Chitraju, C.; Boland, S.; Jang, D.-K.; von Grotthuss, M.; Costanzo, M. C.; Flannick, J.; Burtt, N. P.; Farese, R. A.; Walther, T. C.
10.1101/2021.06.08.447431 — systems biology — Posted on 2021-06-09
2982 It happened again: convergent evolution of acylglucose specialized metabolism in black nightshade and wild tomato
Lou, Y.-R.; Anthony, T. M.; Fiesel, P. D.; Arking, R. E.; Christensen, E. M.; Jones, A. D.; Last, R. L.
10.1101/2021.06.08.447545 — plant biology — Posted on 2021-06-09
2983 Populus ERF85 balances xylem cell expansion and secondary cell wall formation in hybrid aspen
Seyfferth, C.; Wessels, B. A.; Vahala, J.; Kangasjarvi, J.; Delhomme, N.; Hvidsten, T. R.; Tuominen, H.; Felten, J.
10.1101/2021.06.08.447517 — plant biology — Posted on 2021-06-09
2985 Thin-Film Freeze-Drying of a Norovirus Vaccine Candidate
Xu, H.; Bhowmik, T.; Gong, K.; Huynh, T. N. A.; Williams, R. O.; Cui, Z.
10.1101/2021.06.08.447451 — pharmacology and toxicology — Posted on 2021-06-09
2986 Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study
Iida, M. A.; Farrell, K.; Walker, J. M.; Richardson, T. E.; Marx, G.; Bryce, C. H.; Purohit, D.; Ayalon, G.; Beach, T. G.; Bigio, E. H.; Cortes, E.; Gearing, M.; Haroutunian, V.; McMillan, C. T.; Lee, E. B.; Dickson, D.; McKee, A. C.; Stein, T. D.; Trojanowski, J. Q.; Woltjer, R. L.; Kovacs, G. G.; Kofler, J. K.; Kaye, J.; White, C. L.; Crary, J. F.
10.1101/2021.06.08.447553 — pathology — Posted on 2021-06-09
2988 A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines
Feola, S.; Chiaro, J.; Martins, B.; Russo, S.; Fusciello, M.; Ylosmaki, E.; Hamdan, F.; Feodoroff, M.; Antignani, G.; Viitala, T.; Pesonen, S.; Gronholm, M.; Branca, R. M. M.; Lehtio, J.; Cerullo, V.
10.1101/2021.06.08.447483 — cancer biology — Posted on 2021-06-09
2992 Balanced-detection visible-light optical coherence tomography
Rubinoff, I.; Miller, D. A.; Kuranov, R.; Wang, Y.; Fang, R.; Volpe, N. J.; Zhang, H. F.
10.1101/2021.06.08.447560 — bioengineering — Posted on 2021-06-09
2993 Rapid simultaneous acquisition of macromolecular tissue volume, susceptibility, and relaxometry maps
Yu, F. F.; Huang, S. Y.; Kumar, A.; Witzel, T.; Liao, C.; Duval, T.; Cohen-Adad, J.; Bilgic, B.
10.1101/2021.06.08.447552 — bioengineering — Posted on 2021-06-09
2994 The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour
Oliveira, A. S.; Shoemark, D.; Ibarra, A. A.; Davidson, A. D.; Berger, I.; Schaffitzel, C.; Mulholland, A. J.
10.1101/2021.06.07.447341 — biochemistry — Posted on 2021-06-09
2995 Cellular Activities of SARS-CoV-2 Main Protease Inhibitors Reveal Their Unique Characteristics
Cao, W.; Cho, C.-C. D.; Geng, Z. Z.; Ma, X. R.; Allen, R.; Shaabani, N.; Vatansever, E. C.; Alugubelli, Y. R.; Ma, Y.; Ellenburg, W. H.; Yang, K. S.; Qiao, Y.; Ji, H.; Xu, S.; Liu, W. R.
10.1101/2021.06.08.447613 — biochemistry — Posted on 2021-06-09
2997 Genomics analysis of hexanoic acid exposure in Drosophila species
Coolon, J. D.; Drum, Z.; Lanno, S.; Gregory, S.; Shimshak, S.; Ahamed, M.; Barr, W.; Bekele, B.; Biester, A.; Castro, C. D.; Connolly, L.; DelGaudio, N.; Humphrey, W.; Karimi, H.; Karolczak, S.; Lawrence, T.-S.; McCracken, A.; Miller-Medzon, N.; Murphy, L.; Park, C.; Park, S.; Qiu, C.; Serra, K.; Snyder, G.; Strauss, A.; Tang, S.; Vyzas, C.
10.1101/2021.06.08.447576 — genomics — Posted on 2021-06-09
2998 The role of nature conservation and commercial farming in psychological distress among rural Ugandans
Pienkowski, T.; Keane, A.; Kinyanda, E.; Knizek, B. L.; Asiimwe, C.; Muhanguzi, G.; Milner-Gulland, E. J.
10.1101/2021.06.08.446718 — ecology — Posted on 2021-06-09
3000 Lyso-Phosphatidic Acid Acyl-Transferases: a link with intracellular protein transport in Arabidopsis root cells?
Wattelet-Boyer, V.; Le-Guedard, M.; Dittrich-Domergue, F.; Maneta-Peyret, L.; Kriechbaumer, V.; Boutte, Y.; Bessoule, J.-J.; Moreau, P.
10.1101/2021.06.08.447563 — cell biology — Posted on 2021-06-09
3002 Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection
Halwe, S.; Kupke, A.; Vanshylla, K.; Liberta, F.; Gruell, H.; Zehner, M.; Rohde, C.; Kraehling, V.; Gellhorn-Serra, M.; Kreer, C.; Kluever, M.; Sauerhering, L.; Schmidt, J.; Cai, Z.; Han, F.; Young, D.; Yang, G.; Widera, M.; Koch, M.; Werner, A.; Kaemper, L.; Becker, N.; Marlow, M. S.; Eickmann, M.; Ciesek, S.; Schiele, F.; Klein, F.; Becker, S.
10.1101/2021.06.09.447662 — microbiology — Posted on 2021-06-09
3004 Evidence for Deleterious Antigenic Imprinting in SARS-CoV-2 Immune Response
Sen, S. R.; Sanders, E. C.; Santos, A. M.; Bhuvan, K.; Tang, D. Y.; Gelston, A. A.; Miller, B. M.; Ricks-Oddie, J. L.; Weiss, G. A.
10.1101/2021.05.21.445201 — immunology — Posted on 2021-06-09
3005 Immunogenicity and In vivo protection of a variant nanoparticle vaccine that confers broad protection against emerging SARS-CoV-2 variants
Logue, J.; Johnson, R.; Patel, N.; Zhou, B.; Maciejewski, S.; Zhou, H.; Portnoff, A.; Tian, J.-H.; McGrath, M.; Haupt, R.; Weston, S.; Hammod, H.; Guebre-Xabier, M.; Dillen, C.; Plested, J.; Cloney-Clark, S.; Greene, A.; Massare, M.; Glenn, G.; Smith, G.; Frieman, M.
10.1101/2021.06.08.447631 — immunology — Posted on 2021-06-09
3006 The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 B.1.351 and other variants of concern in preclinical studies.
Spencer, A. J.; Morris, S.; Ulaszewska, M.; Powers, C.; Kaliath, R.; Bissett, C. D.; Truby, A.; Thakur, N.; Newman, J.; Allen, E. R.; Lui, C.; Dejnirattisai, W.; Mongkolsapaya, J.; Davies, H.; Donnellan, F. R.; Pulido, D.; Peacock, T. P.; Barclay, W. S.; Bright, H.; Ren, K.; Screaton, G.; McTammy, P.; Bailey, D.; Gilbert, S. C.; Lambe, T.
10.1101/2021.06.08.447308 — immunology — Posted on 2021-06-09
3007 The missing pathway in current visuospatial processing models
Beyh, A.; Dell'Acqua, F.; Sestieri, C.; Caulo, M.; Zappala, G.; Cancemi, D.; De Santiago Requejo, F.; Della Sala, S.; ffytche, D.; Catani, M.
10.1101/2021.06.08.442147 — neuroscience — Posted on 2021-06-09
3008 Hypoxia induced carbonic anhydrase mediated dorsal horn sensory neuron activation and induction ofneuropathic pain
Da Vitoria Lobo, M. E.; Weir, N.; Hardowar, L.; Al Ojaimi, Y.; Madden, R.; Gibson, A.; Schaffer, C.; Hirashima, M.; Donaldson, L. F.; Bates, D. O.; Hulse, R. P.
10.1101/2021.06.08.447539 — neuroscience — Posted on 2021-06-09
3010 Liana optical traits increase tropical forest albedo and reduce ecosystem productivity
Meunier, F.; Visser, M. D.; Shiklomanov, A.; Dietze, M. C.; Guzman, J. A.; Sanchez-Azofeifa, A.; De Deurwaerder, H. P. T.; Krishna Moorty, S. M.; Schnitzer, S. A.; Marvin, D. C.; Longo, M.; Chang, L.; Broadbent, E. N.; Zambrano, A. M. A.; Muller-Landau, H. C.; Detto, M.; Verbeeck, H.
10.1101/2021.06.08.447067 — plant biology — Posted on 2021-06-09
3015 Across-area synchronization supports feature integration in working memory
Barbosa, J.; Babushkin, V.; Temudo, A.; Sreenivasan, K. K.; Compte, A.
10.1101/2021.06.09.447667 — neuroscience — Posted on 2021-06-09
3016 Natural selection and the advantage of recombination
Gerrish, P. J.; Galeota-Sprung, B.; Cordero, F.; Sniegowski, P. D.; Colato, A.; Hengartner, N. W.; Vejalla, V.; Chevalier, J.; Ycart, B.
10.1101/2020.08.28.271486 — evolutionary biology — Posted on 2021-06-09
3017 The effects of an 8-week mindful eating intervention on anticipatory reward responses in striatum and midbrain
Janssen, L. K.; Duif, I.; Speckens, A. E.; van Loon, I.; Wegman, J.; de Vries, J. H.; Cools, R.; Aarts, E.
10.1101/165845 — neuroscience — Posted on 2021-06-09
3019 Tumor cell total mRNA expression shapes the molecular and clinical phenotype of cancer
Cao, S.; Wang, J. R.; Ji, S.; Yang, P.; Montierth, M. D.; Guo, S.; Shen, J. P.; Zhao, X.; Chen, J.; Lee, J. J.; Guerrero, P. A.; Spetsieris, N.; Engedal, N.; Taavitsainen, S.; Yu, K.; Livingstone, J.; Bhandari, V.; Hubert, S. M.; Daw, N. C.; Futreal, A.; Efstathiou, E.; Lim, B.; Viale, A.; Zhang, J.; Nykter, M.; Czerniak, B. A.; Msaouel, P.; Maitra, A.; Kopetz, S.; Campbell, P.; Speed, T. P.; Boutros, P. C.; Zhu, H.; Urbanucci, A.; Demeulemeester, J.; Van Loo, P.; Wang, W.
10.1101/2020.09.30.306795 — genomics — Posted on 2021-06-09
3020 Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations
Thorpe, H. A.; Tourrette, E.; Yahara, K.; Vale, F.; Liu, S.; Oleastro, M.; Alarcon, T.; Perets, T.; Latifi-Navid, S.; Yamaoka, Y.; Martinez-Gonzalez, B.; Karayiannis, I.; Karamitros, T.; Sgouras, D.; Elamin, W.; Pascoe, B.; Sheppard, S.; Ronkainen, J.; Aro, P.; Engstrand, L.; Agreus, L.; Suerbaum, S.; Thorell, K.; Falush, D.
10.1101/2021.06.05.447065 — evolutionary biology — Posted on 2021-06-09
3021 Metacommunities from bacteria to birds: stronger environmental effects in mediterranean than in tropical ponds.
Galvez, A.; Peres-Neto, P. R.; Castillo-Escriva, A.; Bonilla, F.; Camacho, A.; Garcia-Roger, E. M.; Iepure, S.; Miralles-Lorenzo, J.; Monros, J. S.; Olmo, C.; Picazo, A.; Rojo, C.; Rueda, J.; Sahuquillo, M.; Sasa, M.; Segura, M.; Armengol, X.; Mesquita-Joanes, F.
10.1101/2021.03.24.436596 — ecology — Posted on 2021-06-09
3022 Adaptive reprogramming during early seed germination requires temporarily enhanced fermentation a critical role for alternative oxidase (AOX) regulation that concerns also microbiota effectiveness
Revuru, B.; Noceda, C.; Gunasekharan, M.; Kumar, S. R.; Thiers, K. L. L.; Costa, J. H.; Macedo, E. S.; Kumari, A.; Gupta, K. J.; Srivatsava, S.; Adhloeya, A.; Oliveira, M.; Velada, I.; Sircar, D.; Sathishkumar, R.; Arnholdt-Schmitt, B.
10.1101/2021.06.08.447570 — cell biology — Posted on 2021-06-09
3023 Effect sizes and test-retest reliability of the fMRI-based Neurologic Pain Signature
Han, X.; Ashar, Y. K.; Kragel, P.; Petre, B.; Schelkun, V.; Atlas, L.; Chang, L. J.; Jepma, M.; Koban, L.; Losin, E. A. R.; Roy, M.; Woo, C.-W.; Wager, T. D.
10.1101/2021.05.29.445964 — neuroscience — Posted on 2021-06-09
3024 A microRNA Signature of Metastatic Colorectal Cancer
Hoye, E.; Fromm, B.; Bottger, P. H. M.; Domanska, D.; Kristensen, A. T.; Lund-Andersen, C.; Abrahamsen, T. W.; Fretland, A. A.; Dagenborg, V. J.; Lorenz, S.; Edwin, B.; Hovig, E.; Flatmark, K.
10.1101/2020.06.01.127647 — cancer biology — Posted on 2021-06-09
3025 Epithelial-mesenchymal plasticity through loss of CTCF motif accessibility and protein expression
Johnson, K. S.; Hussein, S.; Chakraborty, P.; Muruganantham, A.; Mikhail, S.; Gonzalez, G.; Song, S.; Jolly, M. K.; Toneff, M. J.; Benton, M. L.; Lin, Y. C.; Taube, J.
10.1101/2021.06.08.447526 — cell biology — Posted on 2021-06-09
3027 Generation of ENSEMBL-based proteogenomics databases boosts the identification of non-canonical peptides.
Umer, H. M.; Zhu, Y.; Pfeuffer, J.; Sachsenberg, T.; Lehtio, J.; Branca, R. M. M.; Perez-Riverol, Y.
10.1101/2021.06.08.447496 — bioinformatics — Posted on 2021-06-09
3029 DeGlyPHER: an ultrasensitive method for analysis of viral spike N-glycoforms
Baboo, S.; Diedrich, J. K.; Martinez-Bartolome, S.; Wang, X.; Schiffner, T.; Groschel, B.; Schief, W. R.; Paulson, J. C.; Yates, J. R.
10.1101/2021.05.13.444041 — biochemistry — Posted on 2021-06-09
3031 On the generalizability of diffusion MRI signal representations across acquisition parameters, sequences and tissue types: chronicles of the MEMENTO challenge.
De Luca, A.; Ianus, A.; Leemans, A.; Palombo, M.; Shemesh, N.; Zhang, H.; Alexander, D. C.; Nilsson, M.; Froeling, M.; Biessels, G.-J.; Zucchelli, M.; Frigo, M.; Albay, E.; Sedlar, S.; Alimi, A.; Deslauriers-Gauthier, S.; Deriche, R.; Fick, R.; Afzali, M.; Pieciak, T.; Bogusz, F.; Aja-Fernandez, S.; Ozarslan, E.; Jones, D. K.; Chen, H.; Jin, M.; Zhang, Z.; Wang, F.; Nath, V.; Parvathaneni, P.; Morez, J.; Sijbers, J.; Jeurissen, B.; Fadnavis, S.; Endres, S.; Rokem, A.; Garyfallidis, E.; Sanchez, I.; Prchkovska, V.; Rodrigues, P.; Landman, B. A.; Schilling, K. G.
10.1101/2021.03.02.433228 — neuroscience — Posted on 2021-06-09
3032 RiboReport - Benchmarking tools for ribosome profiling-based identification of open reading frames in bacteria
Gelhausen, R.; Müller, T.; Svensson, S.; Alkhnbashi, O. S.; Sharma, C. M.; Eggenhofer, F.; Backofen, R.
10.1101/2021.06.08.447495 — bioinformatics — Posted on 2021-06-09
3033 Implementing the re-use of public DIA proteomics datasets: from the PRIDE database to Expression Atlas
Walzer, M.; Garcia-Seisdedos, D.; Prakash, A.; Brack, P.; Crowther, P.; Graham, R. L.; George, N.; Mohammed, S.; Moreno, P.; Papatheodorou, I.; Hubbard, S. J.; Vizcaino, J. A.
10.1101/2021.06.08.447493 — bioinformatics — Posted on 2021-06-09
3034 Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex
Valk, S. L.; Xu, T.; Paquola, C.; Park, B.-y.; Bethlehem, R. A.; Vos de Wael, R.; Royer, J.; Kharabian Masouleh, S.; Bayrak, S.; Kochunov, P.; Yeo, B. T.; Margulies, D.; Smallwood, J.; Eickhoff, S. B.; Bernhardt, B. C.
10.1101/2021.06.08.447522 — neuroscience — Posted on 2021-06-09
3036 Systematic reconstruction of the cellular trajectories of mammalian embryogenesis
Qiu, C.; Cao, J.; Li, T.; Srivatsan, S.; Huang, X.; Calderon, D.; Noble, W. S.; Disteche, C. M.; Spielmann, M.; Moens, C. B.; Trapnell, C.; Shendure, J.
10.1101/2021.06.08.447626 — developmental biology — Posted on 2021-06-09
3037 Tracheal motile cilia in mice require CAMSAP3 for formation of central microtubule pair and coordinated beating
Saito, H.; Matsukawa-Usami, F.; Fujimori, T.; Kimura, T.; Ide, T.; Yamamoto, T.; Shibata, T.; Onoue, K.; Okayama, S.; Yonemura, S.; Misaki, K.; Soba, Y.; Kakui, Y.; Sato, M.; Toya, M.; Takeichi, M.
10.1101/2021.04.21.440849 — cell biology — Posted on 2021-06-08
3039 GeneCup: mine PubMed for gene relationships using custom ontology and deep learning
Gunturkun, M. H.; Flashner, E.; Wang, T.; Mulligan, M. K.; Williams, R. W.; Prins, P.; Chen, H.
10.1101/2020.09.17.297358 — bioinformatics — Posted on 2021-06-08
3042 {-}{-} Histone H2B.V demarcates strategic regions in the Trypanosoma cruzi genome, associates with a bromodomain factor and affects parasite differentiation and host cell invasion
Roson, J. N.; Vitarelli, M. O.; Costa-Silva, H. M.; Pereira, K. S.; Pires, D. d. S.; Lopes, L. d. S.; Cordeiro, B.; Kraus, A. J.; Cruz, K. N. T.; Calderano, S. G.; Fragoso, S. P.; Siegel, T. N.; Elias, M. C.; da Cunha, J. P. C.
10.1101/2021.06.08.447515 — microbiology — Posted on 2021-06-08
3044 Genetic stability of Aedes aegypti populations following invasion by wMel Wolbachia
Lau, M.-J.; Schmidt, T.; Yang, Q.; Chung, J.; Sankey, L.; Ross, P. A.; Hoffmann, A. A.
10.1101/2021.06.03.446908 — evolutionary biology — Posted on 2021-06-08
3046 FINE-SCALE ADAPTATIONS TO ENVIRONMENTAL VARIATION AND GROWTH STRATEGIES DRIVE PHYLLOSPHERE METHYLOBACTERIUM DIVERSITY.
Leducq, J.-B.; Seyer-Lamontagne, E.; Condrain-Morel, D.; Bourret, G.; Sneddon, D.; Foster, J. A.; Marx, C. J.; Sullivan, J. M.; Shapiro, B. J.; Kembel, S. W.
10.1101/2021.06.04.447128 — microbiology — Posted on 2021-06-08
3047 Clarification of human blood ILC subtype interrelatedness and discovery of amphiregulin production by human NK cells shed light on HIV-1 pathogenesis
Wang, Y.; Lifshitz, L.; Silverstein, N.; Mintzer, E.; Luk, K.; StLouis, P.; Brehm, M.; Wolfe, S.; Deeks, S.; Luban, J.
10.1101/2021.04.20.440368 — immunology — Posted on 2021-06-08
3048 Potential therapy for progressive vision loss due to PCDH15-associated Usher syndrome developed in an orthologous Usher mouse
Sethna, S.; Zein, W. M.; Riaz, S.; Giese, A. P. J.; Schultz, J. M.; Duncan, T.; Hufnagel, R. B.; Brewer, C. C.; Griffith, A. J.; Redmond, T. M.; Riazuddin, S.; Friedman, T. B.; Ahmed, Z. M.
10.1101/2021.06.08.447565 — neuroscience — Posted on 2021-06-08
3054 Distribution and vulnerability of transcriptional outputs across the genome in Myc-amplified medulloblastoma cells
Yang, R.; Wang, W.; Dong, M.; Roso, K.; Greer, P.; Bao, X.; Pirozzi, C. J.; Bigner, D. D.; Yan, H.; Ashley, D. M.; Zou, F.; Zhabotynsky, V.; He, Y.
10.1101/2021.06.07.447394 — cancer biology — Posted on 2021-06-08
3055 An Explainable Deep Learning Approach for Multimodal Electrophysiology Classification
Ellis, C. A.; Carbajal, D. A.; Zhang, R.; Miller, R. L.; Calhoun, V. D.; Wang, M. D.
10.1101/2021.05.12.443594 — bioinformatics — Posted on 2021-06-08
3056 Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation
Orth, M. F.; Surdez, D.; Marchetto, A.; Grossetete, S.; Gerke, J. S.; Zaidi, S.; Alonso, J.; Sastre, A.; Baulande, S.; Sill, M.; Cidre-Aranaz, F.; Ohmura, S.; Kirchner, T.; Hauck, S. M.; Reischl, E.; Gymrek, M.; Pfister, S. M.; Strauch, K.; Delattre, O.; Grunewald, T. G. P.
10.1101/2021.06.08.447518 — genomics — Posted on 2021-06-08
3057 Genetic architecture of natural variations of cardiac performance in flies
Saha, S.; Spinelli, L.; Castro-Mondragon, J. A.; Kervadec, A.; Kremmer, L.; Roder, L.; Krifa, S.; Torres, M.; Brun, C.; Vogler, G.; Bodmer, R.; COLAS, A.; Ocorr, K.; Perrin, L.
10.1101/2021.06.08.447524 — genetics — Posted on 2021-06-08
3062 Decreased KATP channel activity contributes to the low glucose threshold for insulinsecretion in the early postnatal period
Yang, J.; Hammoud, B.; Li, C.; Ridler, A.; Yau, D.; Kim, J.; Won, K.-J.; Stanley, C. A.; Hoshi, T.; Stanescu, D. E.
10.1101/2021.03.04.433947 — developmental biology — Posted on 2021-06-08
3063 ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
Hancock-Cerutti, W. F.; Wu, Z.; Tharkeshwar, A. K.; Ferguson, S. M.; Shadel, G. S.; De Camilli, P.
10.1101/2021.06.08.447593 — cell biology — Posted on 2021-06-08
3065 Genomic insights of high-risk clones of ESBL-producing Escherichia coli isolated from community infections and commercial meat in Southern Brazil
Soncini, J. G.; Cerdeira, L.; Koga, V. L.; Tizura, A. T.; Fuga, B.; Nakazato, G.; Kobayashi, R.; Aires, C. A. M.; Lincopan, N.; Vespero, E. C.
10.1101/2020.12.31.424884 — microbiology — Posted on 2021-06-08
3066 Context-aware genomic surveillance reveals hidden transmission of a carbapenemase-producing Klebsiella pneumoniae
Viehweger, A.; Blumenscheit, C.; Lippmann, N.; Wyres, K. L.; Brandt, C.; Hans, J. B.; Hölzer, M.; Irber, L.; Gatermann, S.; Lübbert, C.; Pletz, M.; Holt, K. E.; König, B.
10.1101/2021.06.07.447408 — microbiology — Posted on 2021-06-08
3068 Nanoscale organization and calcium influx in dendritic spines guarantee ER store refilling without depletion
Basnayake, K.; Mazaud, D.; Kushnireva, L.; Bemelmans, A.; Rouach, n.; Korkotian, E.; holcman, d.
10.1101/2021.06.08.447402 — neuroscience — Posted on 2021-06-08
3069 The Innate Immune Response to Invasive Pulmonary Aspergillosis: A Systems Modeling Approach
Ribeiro, H. A.; Sordo Vieira, L.; Scindia, Y.; Adhikari, B.; Wheeler, M.; Knapp, A.; Schroeder, W.; Mehrad, B.; Laubenbacher, R.
10.1101/2021.06.08.447590 — systems biology — Posted on 2021-06-08
3073 A mechano-osmotic feedback couples cell volume to the rate of cell deformation
Venkova, L.; Vishen, A. S.; Lembo, S.; Srivastava, N.; Duchamp, B.; Ruppel, A.; Vassilopoulos, S.; Deslys, A.; Garcia Arcos, J. M.; Diz-Munoz, A.; Balland, m.; Joanny, J.-F.; Cuvelier, D.; Sens, P.; Piel, M.
10.1101/2021.06.08.447538 — biophysics — Posted on 2021-06-08
3075 Foster thy young: Enhanced prediction of orphan genes in assembled genomes
Li, J.; Singh, U.; Bhandary, P.; Campbell, J.; Arendsee, Z.; Seetharam, A. S.; Wurtele, E. S.
10.1101/2019.12.17.880294 — bioinformatics — Posted on 2021-06-08
3079 An Efficient and Cost-effective Purification Methodology for Cas9 Nuclease
Teng, A. C. T.; Tavassoli, M.; Shrestha, S.; Lindsay, K.; Ivakine, E.; Cohn, R.; Santerre, J. P.; Gramolini, A. O.
10.1101/2021.06.08.447622 — biochemistry — Posted on 2021-06-08
3080 Population structure analysis and laboratory monitoring of Shigella with a standardised core-genome multilocus sequence typing scheme: a validation study
Yassine, I.; Lefevre, S.; Hansen, E. E.; Ruckly, C.; Carle, I.; Lejay-Collin, M.; Fabre, L.; Rafei, R.; Clermont, D.; Pardos de la Gandara, M.; Dabboussi, F.; Thomson, N. R.; Weill, F.-X.
10.1101/2021.06.08.447214 — genomics — Posted on 2021-06-08
3083 Convergent loss of the necroptosis pathway in disparate mammalian lineages shapes virus countermeasures
Pinto, A. A.; Alves, L. Q.; Neves, F.; McFadden, G.; Jacobs, B. L.; Castro, F.; Rahman, M. M.; Esteves, P. J.
10.1101/2021.06.08.447400 — evolutionary biology — Posted on 2021-06-08
3084 The Streptochaeta genome and the evolution of the grasses
Seetharam, A. S.; Yu, Y.; Belanger, S.; Clark, L. G.; Meyers, B. C.; Kellogg, E. A.; Hufford, M. B.
10.1101/2021.06.08.444730 — evolutionary biology — Posted on 2021-06-08
3088 Cortical waves mediate the cellular response to electric fields
Yang, Q.; Miao, Y.; Campanello, L. J.; Hourwitz, M. J.; Bull, A. L.; Devreotes, P. N.; Fourkas, J. T.; Losert, W.
10.1101/2021.06.08.447600 — cell biology — Posted on 2021-06-08
3090 Analysis of subcellular transcriptomes by RNA proximity labeling with Halo-seq
Engel, K. L.; Lo, H.-Y. G.; Goering, R.; Li, Y.; Spitale, R.; Taliaferro, M.
10.1101/2021.06.08.447604 — molecular biology — Posted on 2021-06-08
3091 Shrimp parvovirus circular DNA fragments arise from both endogenous viral elements (EVE) and the infecting virus
Taengchaiyaphum, S.; Buathongkam, P.; Sukthaworn, S.; Wongkhaluang, P.; Sritunyalucksana, K.; Flegel, T. W.
10.1101/2021.06.08.447433 — molecular biology — Posted on 2021-06-08
3092 The Ebola virus matrix protein clusters phosphatidylserine, a critical step in viral budding
Husby, M. L.; Amiar, S.; Prugar, L. I.; David, E. A.; Plescia, C. B.; Huie, K. E.; Brannan, J. M.; Dye, J. M.; Pienaar, E.; Stahelin, R. V.
10.1101/2021.06.08.447555 — microbiology — Posted on 2021-06-08
3093 Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection
Ramon, A. C.; Perez, G. V.; Caballero, E.; Rosales, M.; Aguilar, D.; Vazquez-Blomquist, D. M.; Ramos, Y.; Rodriguez, A.; Falcon, V.; Rodriguez, M. P.; Ke, Y.; Perera, Y.; Perea, S. E.
10.1101/2021.06.08.447588 — pharmacology and toxicology — Posted on 2021-06-08
3094 Locally secreted BiTEs complement CAR T cells by enhancing solid tumor killing
Yin, Y.; Rodriguez, J.; Li, N.; Thokala, R.; Nasrallah, M. P.; Hu, L.; Zhang, L.; Zhang, J. V.; Kainth, D.; Haddad, L.; Johns, E. X.; Long, Y.; Liang, H.; Qi, J.; Zhang, X.; Binder, Z. A.; Lin, Z.; O'Rourke, D. M.
10.1101/2021.06.08.447602 — cancer biology — Posted on 2021-06-08
3096 Single domain shark VNAR antibodies neutralize SARS-CoV-2 infection in vitro
Gauhar, A.; Privezentzev, C. V.; Demydchuk, M.; Gerlza, T.; Rieger, J.; Kungl, A. J.; Walsh, F. S.; Rutkowski, J. L.; Stocki, P.
10.1101/2021.06.08.447530 — bioengineering — Posted on 2021-06-08
3098 ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
Hancock-Cerutti, W. F.; Wu, Z.; Tharkeshwar, A. K.; Ferguson, S. M.; Shadel, G. S.; De Camilli, P.
10.1101/2021.06.08.447593 — cell biology — Posted on 2021-06-08
3099 ROS/RNS balancing, aerobic fermentation regulation and cell cycle control a complex early trait ('CoV-MAC-TED') for combating SARS-CoV-2-induced cell reprogramming
Costa, J. H.; Mohanapriya, G.; Revuru, B.; Noceda, C.; Thiers, K. L. L.; Aziz, S.; Srivatsava, S.; Oliveira, M.; Gupta, K. J.; Kumari, A.; Sircar, D.; Kumar, S. R.; Achra, A.; Sathishkumar, R.; Adhloeya, A.; Arnholdt-Schmitt, B.
10.1101/2021.06.08.447491 — cell biology — Posted on 2021-06-08
3102 Bacterioplankton Diversity and Distribution in Relation to Phytoplankton Community Structure in the Ross Sea surface waters
Cordone, A.; D'Errico, G.; Magliulo, M.; Bolinesi, F.; Selci, M.; Basili, M.; de Marco, R.; Saggiomo, M.; Rivaro, P.; Giovannelli, D.; Mangoni, O.
10.1101/2021.06.08.447544 — microbiology — Posted on 2021-06-08
3103 In depth analysis of Cyprus-specific mutations of SARS-CoV-2 strains using computational approaches
Oulas, A.; Richter, J.; Zanti, M.; Tomazou, M.; Michailidou, K.; Christodoulou, K.; Christodoulou, C.; Spyrou, G. M.
10.1101/2021.06.08.447477 — bioinformatics — Posted on 2021-06-08
3104 FXa cleaves the SARS-CoV-2 spike protein and blocks cell entry to protect against infection with inferior effects in B.1.1.7 variant
Yu, J.; Dong, W.; Wang, J.; Tian, L.; Zhang, J.; Mead, H. L.; Jaramillo, S.; Li, A.; Zumwalt, R.; Whelan, S. P. J.; Settles, E.; Keim, P.; Barker, B. M.; Caligiuri, M.
10.1101/2021.06.07.447437 — microbiology — Posted on 2021-06-08
3105 The expression of virulence increases outer-membrane permeability and sensitivity to envelope stress in Salmonella Typhimurium
Sobota, M.; Rodilla Ramirez, P. N.; Cambre, A.; Haas, T.; Cornillet, D.; Rocker, A.; Aertsen, A.; Diard, M.
10.1101/2021.06.08.447568 — microbiology — Posted on 2021-06-08
3106 Seed microbiota revealed by a large-scale meta-analysis including 50 plant species
Simonin, M.; Briand, M.; Chesneau, G.; Rochefort, A.; Marais, C.; Sarniguet, A.; Barret, M.
10.1101/2021.06.08.447541 — microbiology — Posted on 2021-06-08
3107 The transcription factor Roc1 is a regulator of cellulose degradation in the wood-decaying mushroom Schizophyllum commune
Marian, I. M.; Vonk, P. J.; Valdes, I. D.; Barry, K.; Bostock, B.; Carver, A.; Daum, C.; Lerner, H.; Lipzen, A.; Park, H.; Schuller, M. B. P.; Tegelaar, M.; Tritt, A.; Schmutz, J.; Grimwood, J.; Lugones, L. G.; Choi, I.-G.; Wosten, H. A. B.; Grigoriev, I. V.; Ohm, R. A.
10.1101/2021.06.08.446897 — microbiology — Posted on 2021-06-08
3110 Peer presence and familiarity as key factors to reduce cocaine intake: an effect mediated by the Subthalamic Nucleus
Giorla, E.; Nordmann, S.; Vielle, C.; Pelloux, Y.; Roux, P.; Protopopescu, C.; Manrique, C.; Davranche, K.; Montanari, C.; Giorgi, L.; Vilotitch, A.; Huguet, P.; Carrieri, P.; BAUNEZ, C.
10.1101/2021.06.08.447497 — neuroscience — Posted on 2021-06-08
3111 Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability
Caldeira, G. L.; Inacio, A. S.; Beltrao, N.; Barreto, C. A. V.; Rodrigues, M. V.; Rondao, T.; Macedo, R.; Gouveia, R. P.; Edfawy, M.; Guedes, J.; Cruz, B.; Louros, S. R.; Moreira, I. S.; Peca, J.; Carvalho, A. L.
10.1101/2021.06.08.447333 — neuroscience — Posted on 2021-06-08
3113 Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythrocytes
Chen, Y.; Dong, Y.; Lu, X.; Li, W.; Zhang, Y.; Mao, B.; Pan, X.; Li, X.; Zhou, Y.; An, Q.; Xie, F.; Wang, S.; Xue, Y.; Cai, X.; Lai, M.; Zhou, Q.; Yan, Y.; Fu, R.; Wang, H.; Nakahata, T.; An, X.; Shi, L.; Zhang, Y.; Ma, F.
10.1101/2021.06.08.447482 — cell biology — Posted on 2021-06-08
3115 Adaptive reprogramming during early seed germination requires temporarily enhanced fermentation a critical role for alternative oxidase (AOX) regulation that concerns also microbiota effectiveness
Revuru, B.; Noceda, C.; Gunasekharan, M.; Kumar, S. R.; Thiers, K. L. L.; Costa, J. H.; Macedo, E. S.; Kumari, A.; Gupta, K. J.; Srivatsava, S.; Adhloeya, A.; Oliveira, M.; Velada, I.; Sircar, D.; Arnholdt-Schmitt, B.; Sathishkumar, R.
10.1101/2021.06.08.447570 — cell biology — Posted on 2021-06-08
3117 Cool temperatures limit Zika virus genome replication
Tesla, B.; Powers, J. S.; Barnes, Y.; Lakhani, S.; Acciani, M. D.; Murdock, C. C.; Brindley, M. A.
10.1101/2021.06.07.447476 — microbiology — Posted on 2021-06-08
3118 A personalized anti-cancer vaccine for melanoma based on an approved vaccine against measles, mumps, and rubella
Ylosmaki, E.; Fusciello, M.; Uoti, A.; Feola, S.; Martins, B.; Aalto, K.; Hamdan, F.; Ciaro, J.; Viitala, T.; Cerullo, V.
10.1101/2021.06.07.447462 — immunology — Posted on 2021-06-08
3121 How perception and attention participate in reading skill?
Gudwani, S.; Mehta, M.; Sagar, R.; Behari, M.; Narang, V.; Dwivedi, S.; Jagannathan, N. R.; Kumaran, S. S.
10.1101/2021.06.07.447429 — neuroscience — Posted on 2021-06-08
3122 Rat anterior cingulate cortex continuously signals decision variables in a patchforaging task
Kane, G. A.; James, M. H.; Shenhav, A.; Daw, N. D.; Cohen, J. D.; Aston-Jones, G.
10.1101/2021.06.07.447464 — neuroscience — Posted on 2021-06-08
3123 Conservation and diversity in transcriptional responses among host plants forming distinct arbuscular mycorrhizal morphotypes
Tominaga, T.; Miura, C.; Sumigawa, Y.; Hirose, Y.; Yamaguchi, K.; Shigenobu, S.; Mine, A.; Kaminaka, H.
10.1101/2021.06.07.447186 — plant biology — Posted on 2021-06-08
3124 Nutrient profiling reveals extracellular uridine as a fuel for pancreatic cancer through uridine phosphorylase 1
Ward, M. H.; Nwosu, Z. C.; Poudel, P.; Kasperek, S.; Tolstyka, Z.; Menjivar, R. E.; Ragulan, C.; Nyamundanda, G.; Zhang, L.; Andren, A.; Halbrook, C. J.; Carpenter, E. S.; Pasca di Magliano, M.; Sadanandam, A.; Lyssiotis, C. A.
10.1101/2021.06.07.447448 — cancer biology — Posted on 2021-06-08
3125 Super-cells untangle large and complex single-cell transcriptome networks
Bilous, M.; Tran, L.; Cianciaruso, C.; Carmona, S. J.; Pittet, M. J.; Gfeller, D.
10.1101/2021.06.07.447430 — bioinformatics — Posted on 2021-06-08
3126 Viral Evasion of the Integrated Stress Response Through Antagonistic eIF2-P Mimicry
Schoof, M.; Wang, L.; Cogan, J. Z.; Lawrence, R.; Boone, M.; Wuerth, J. D.; Frost, A.; Walter, P.
10.1101/2021.06.07.447473 — biochemistry — Posted on 2021-06-08
3127 Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex
Codeluppi, S. A.-M.; Chatterjee, D.; Prevot, T. D.; Bansal, Y.; Misquitta, K. A.; Sibille, E.; Banasr, M.
10.1101/2021.02.23.432559 — animal behavior and cognition — Posted on 2021-06-08
3128 Differential ampicillin/ceftriaxone susceptibility among diverse Enterococcus faecalis from infective endocarditis
Westbrook, K. J.; Chilambi, G. S.; Nordstrom, H. R.; Iovleva, A.; Shah, N. H.; Jones, C. E.; Kline, E. G.; Doi, Y.; Shields, R. K.; Van Tyne, D.
10.1101/2021.06.07.447474 — microbiology — Posted on 2021-06-08
3132 Cognitive functions and respective parameters of human brain physiology are chronotype-dependent
Salehinejad, M. A.; Wischnewski, M.; Ghanavati, E.; Mosayebi-Samani, M.; Kuo, M.-F.; Nitsche, M. A.
10.1101/2021.06.08.447543 — neuroscience — Posted on 2021-06-08
3134 The payoffs and tradeoffs of hygienic behavior: A large-scale field study on a local population of honey bees
Seltzer, R.; Kahanov, P.; Kamer, Y.; Hetzroni, A.; Bienkowska, M.; Hefetz, A.; Soroker, V.
10.1101/2021.06.07.447383 — pathology — Posted on 2021-06-08
3135 Explainable Sleep Stage Classification with Multimodal Electrophysiology Time-series
Ellis, C. A.; Zhang, R.; Carbajal, D. A.; Miller, R. L.; Calhoun, V. D.; Wang, M. D.
10.1101/2021.05.04.442658 — bioinformatics — Posted on 2021-06-08
3137 Paradoxes and synergies: optimizing management of a deadly virus in an endangered carnivore
Gilbertson, M. L. J.; Onorato, D.; Cunningham, M. W.; VandeWoude, S.; Craft, M. E.
10.1101/2021.01.11.426249 — ecology — Posted on 2021-06-08
3141 DRUG-seq Provides Unbiased Biological Activity Readouts for Drug Discovery
Li, J.; Ho, D. J.; Henault, M.; Yang, C.; Neri, M.; Ge, R.; Renner, S.; Mansur, L.; Lindeman, A.; Tumkaya, T.; Russ, C.; Hild, M.; Gubser Keller, C.; Jenkins, J. L.; Worringer, K. A.; Sigoillot, F. D.; Ihry, R. J.
10.1101/2021.06.07.447456 — genomics — Posted on 2021-06-08
3142 A screen of covalent inhibitors in Mycobacterium tuberculosis identifies serine hydrolases involved in lipid metabolism as potential therapeutic targets
Babin, B. M.; Keller, L. J.; Pinto, Y.; Li, V. L.; Eneim, A.; Vance, S. E.; Terrell, S. M.; Bhatt, A. S.; Long, J. Z.; Bogyo, M.
10.1101/2021.06.07.447460 — microbiology — Posted on 2021-06-08
3143 Exploring the Self-Assembly of Encapsulin Protein Nanocages from Different Structural Classes
Boyton, I.; Goodchild, S. C.; Diaz, D.; Elbourne, A.; Collins-Praino, L.; Care, A.
10.1101/2021.06.06.447285 — biophysics — Posted on 2021-06-08
3149 Mechanistic insights into the success of xenobiotic degraders resolved from metagenomes of microbial enrichment cultures
Li, J.; Jia, C.; Lu, Q.; Hungate, B. A.; Dijkstra, P.; Wang, S.; Wu, C.; Chen, S.; Li, D.; Shim, H.
10.1101/2021.03.03.433815 — microbiology — Posted on 2021-06-08
3154 Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data
A.Yones, S.; Annett, A.; Stoll, P.; Diamanti, K.; Holmfeldt, L.; Fredrik Barrenäs, C.; Meadows, J. R. S.; Komorowski, J.
10.1101/2021.06.03.446884 — bioinformatics — Posted on 2021-06-08
3156 Generation of nonlinear and spatially-organized 3D cultures on a microfluidic chip using photoreactive thiol-ene and methacryloyl hydrogels
Ortiz-Cardenas, J. E.; Zatorski, J. M.; Arneja, A.; Montalbine, A. N.; Munson, J. M.; Luckey, C. J.; Pompano, R. R.
10.1101/2020.09.09.287870 — bioengineering — Posted on 2021-06-08
3158 The Neural Determinants of Beauty
Yang, T.; Formuli, A.; Paolini, M.; Zeki, S.
10.1101/2021.05.21.444999 — neuroscience — Posted on 2021-06-08
3159 The impact of brain lesions on tDCS-induced electric field magnitude
Johnstone, A.; Zich, C.; Evans, C.; Lee, J.; Ward, N. S.; Bestmann, S.
10.1101/2021.03.19.436124 — neuroscience — Posted on 2021-06-08
3160 HistoClean: Open-source Software for Histological Image Pre-processing and Augmentation to Improve Development of Robust Convolutional Neural Networks
McCombe, K. D.; Craig, S. G.; Pulsawatdi, A. V.; Quezada-Marin, J. I.; Hagan, M.; Rajendran, S.; Humphries, M. P.; Bingham, V.; Salto-Tellez, M.; Gault, R.; James, J. A.
10.1101/2021.06.07.447339 — cancer biology — Posted on 2021-06-08
3161 Cellular transformation by combined lineage conversion and oncogene expression
Sahu, B.; Pihlajamaa, P.; Zhang, K.; Palin, K.; Ahonen, S.; Cervera, A.; Ristimaki, A.; Aaltonen, L.; Hautaniemi, S.; Taipale, J.
10.1101/525600 — cancer biology — Posted on 2021-06-08
3162 Cryo-EM structure of native human thyroglobulin
Adaixo, R.; Steiner, E. M.; Righetto, R. D.; Schmidt, A.; Stahlberg, H.; Taylor, N. M. I.
10.1101/2021.06.06.447243 — biophysics — Posted on 2021-06-08
3164 Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching
Hopes, T. S.; Norris, K.; Agapiou, M.; McCarthy, C. G.; Lewis, P. A.; O'Connell, M. J.; Fontana, J.; Aspden, J. L.
10.1101/2020.01.20.913020 — biochemistry — Posted on 2021-06-08
3167 Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations
Thorpe, H. M.; Tourrette, E.; Yahara, K.; Vale, F.; Liu, S.; Oleastro, M.; Alarcon, T.; Perets, T.; Latifi-Navid, S.; Yamaoka, Y.; Martinez-Gonzalez, B.; Karayiannis, I.; Karamitros, T.; Sgouras, D.; Elamin, W.; Pascoe, B.; Sheppard, S.; Ronkainen, J.; Aro, P.; Engstrand, L.; Agreus, L.; Suerbaum, S.; Thorell, K.; Falush, D.
10.1101/2021.06.05.447065 — evolutionary biology — Posted on 2021-06-08
3169 Flexible fitting of PROTAC concentration-response curves with changepoint Gaussian Processes
Semenova, E.; Guerriero, M. L.; Zhang, B.; Hock, A.; Hopcroft, P.; Kadamur, G.; Afzal, A. M.; Lazic, S. E.
10.1101/2020.11.13.379883 — cell biology — Posted on 2021-06-08
3170 Distinctive properties of cones in the retinal clock and the circadian system
Sandu, C.; Wongchitrat, P.; Mazzaro, N.; Jaeger, C.; Calligaro, H.; Mendoza, J.; Hicks, D.; Felder-Schmittbuhl, M.-P.
10.1101/2020.09.15.297879 — neuroscience — Posted on 2021-06-08
3173 Variation in Human Herpesvirus 6B telomeric integration, excision and transmission between tissues and individuals
Wood, M. L.; Veal, C. D.; Neumann, R.; Suarez, N. M.; Nichols, J.; Parker, A. J.; Martin, D.; Romaine, S. P. R.; Codd, V.; Samani, N. J.; Voors, A. A.; Tomaszewski, M.; Flamand, L.; Davison, A. J.; Royle, N. J.
10.1101/2021.06.07.447326 — genetics — Posted on 2021-06-08
3174 Constitutive AP2gamma deficiency reduces postnatal hippocampal neurogenesis and induces behavioral deficits in juvenile mice that persist during adulthood
Loureiro-Campos, E.; Alves, N. D.; Mateus-Pinheiro, A.; Patricio, P.; Soares-Cunha, C.; Silva, J.; Sardinha, V. M.; Mendes-Pinheiro, B.; Silveira-Rosa, T.; Rodrigues, A. J.; Oliveira, J.; Sousa, N.; Pinto, L.
10.1101/2021.06.07.447328 — neuroscience — Posted on 2021-06-08
3175 eIF2B-capturing viral protein NSs suppresses the integrated stress response
Kashiwagi, K.; Shichino, Y.; Osaki, T.; Sakamoto, A.; Nishimoto, M.; Takahashi, M.; Mito, M.; Weber, F.; Ikeuchi, Y.; Iwasaki, S.; Ito, T.
10.1101/2021.06.07.447466 — molecular biology — Posted on 2021-06-08
3179 Consistent Tumorigenesis with Self-Assembled Hydrogels Enables High-powered Murine Cancer Studies
Grosskopf, A. K.; Correa, S.; Baillet, J.; Maikawa, C. L.; Gale, E. C.; Brown, R. A.; Appel, E. A.
10.1101/2021.04.13.439705 — bioengineering — Posted on 2021-06-07
3180 Visual gene expression reveals a cone to rod developmental progression in deep-sea fishes
Lupse, N.; Cortesi, F.; Freese, M.; Marohn, L.; Pohlmann, J.-D.; Wysujack, K.; Hanel, R.; Musilova, Z.
10.1101/2020.05.25.114991 — evolutionary biology — Posted on 2021-06-07
3181 Engineering Insulin Cold Chain Resilience to Improve Global Access
Maikawa, C. L.; Mann, J. L.; Kannan, A.; Meis, C. M.; Grosskopf, A. K.; Ou, B. S.; Smith, A. A. A.; Fuller, G. G.; Maahs, D. M.; Appel, E. A.
10.1101/2021.04.13.439582 — bioengineering — Posted on 2021-06-07
3183 Intronic regulation of SARS-CoV-2 receptor (ACE2) expression mediated by immune signaling and oxidative stress pathways
Richard, D.; Muthuirulan, P.; Aguiar, J.; Doxey, A.; Banerjee, A.; Mossman, K.; Hirota, J.; Capellini, T. D.
10.1101/2021.06.07.447351 — genetics — Posted on 2021-06-07
3186 Combinatorial small molecule-mediated activation of CBP/p300 with environmental enrichment in chronic severe experimental spinal cord injury to enable axon regeneration and sprouting for functional recovery
Mueller, F.; De Virgiliis, F.; Kong, G.; Zhou, L.; Serger, E.; Chadwick, J.; Sanchez-Vassopoulos, A.; Akash, S.; Eswaramoorth, M.; Kundu, T.; Di Giovanni, S.
10.1101/2021.06.07.447349 — neuroscience — Posted on 2021-06-07
3187 BrainGNN: Interpretable Brain Graph Neural Network for fMRI Analysis
Li, X.; Zhou, Y.; Zhang, M.; Dvornek, N.; Gao, S.; Zhuang, J.; Scheinost, D.; Staib, L.; Ventola, P.; Duncan, J.
10.1101/2020.05.16.100057 — neuroscience — Posted on 2021-06-07
3189 Small Molecule Stabilization of PINK-1/PINK1 Improves Neurodegenerative Disease
Tjahjono, E.; Pei, J.; Revtovich, A. V.; Liu, T.-J. E.; Swadi, A.; Kirienko, N. V.
10.1101/2021.06.07.447442 — cell biology — Posted on 2021-06-07
3190 Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies
Fenix, A. M.; Miyaoka, Y.; Bertero, A.; Blue, S.; Spindler, M. J.; Tan, K. K. B.; Perez-Bermejo, J. A.; Chan, A. H.; Mayer, S. J.; Nguyen, T.; Russell, C. R.; Lizarraga, P.; Truong, A.; So, P.-L.; Kulkarni, A.; Chetal, K.; Sathe, S.; Sniadecki, N. J.; Yeo, G. W.; Murry, C. E.; Conklin, B. R.; Salomonis, N.
10.1101/2021.06.02.446820 — cell biology — Posted on 2021-06-07
3191 Crash landing of Vibrio cholerae by MSHA pili-assisted braking and anchoring in a viscoelastic environment
Zhang, W.; Luo, M.; Feng, C.; Liu, H.; Zhang, H.; Bennett, R. R.; Utada, A. S.; Liu, Z.; Zhao, K.
10.1101/2020.07.05.188680 — microbiology — Posted on 2021-06-07
3192 Dual roles of a novel oncolytic viral vector-based SARS-CoV-2 vaccine: preventing COVID-19 and treating tumor progression
Caligiuri, M. A.; Yu, J.; Sun, Y.; Dong, W.; Tian, L.; Rao, Y.; Qin, C.; Jaramillo, S. A.; Settles, E. W.; Ma, S.; Zhang, J.; Yu, K.; Xu, B.; Yan, J.; Ma, R.; Li, Z.; Dadwal, S. S.; Barker, B. M.; Keim, P. S.; Feng, P.
10.1101/2021.06.07.447286 — microbiology — Posted on 2021-06-07
3195 Clinically-Driven Design of Synthetic Gene Regulatory Programs in Human Cells
Israni, D. V.; LI, H.; Gagnon, K. A.; Sander, J. D.; Roybal, K. T.; Joung, J. K.; Wong, W.; Khalil, A. S.
10.1101/2021.02.22.432371 — synthetic biology — Posted on 2021-06-07
3196 B1L regulates lateral root development by exocytic vesicular trafficking-mediated polar auxin transport
Gang, Y.; Bi-xia, C.; Tao, C.; Jia-hui, C.; Rui, S.; Cong-cong, L.; Jiao, J.; Xiu-le, Y.; Lizhe, A.; Hua, Z.
10.1101/2021.06.07.447418 — plant biology — Posted on 2021-06-07
3197 Distribution and vulnerability of transcriptional outputs across the genome in Myc-amplified medulloblastoma cells
Yang, R.; Wang, W.; Dong, M.; Roso, K.; Greer, P.; Bao, X.; Pirozzi, C. J.; Bigner, D. D.; Yan, H.; Ashley, D. M.; Zou, F.; Zhabotynsky, V.; He, Y.
10.1101/2021.06.07.447394 — cancer biology — Posted on 2021-06-07
3198 Strain-Programmable Patch for Diabetic Wound Healing
Theocharidis, G.; Yuk, H.; Roh, H.; Wang, L.; Mezghani, I.; Wu, J.; Kafanas, A.; Chen, L.; Guo, C. F.; Jayaswal, N.; Katopodi, X.-L.; Nabzdyk, C.; Vlachos, I.; Veves, A.; Zhao, X.
10.1101/2021.06.07.447423 — bioengineering — Posted on 2021-06-07
3199 Cannabinoids vs. whole metabolome: relevance of cannabinomics in analyzing Cannabis varieties
Vasquez-Ocmin, P.; Marti, G.; Bonhomme, M.; Mathis, F.; Fournier, S.; Bertani, S.; Maciuk, A.
10.1101/2021.06.07.447363 — biochemistry — Posted on 2021-06-07
3200 What we talk about when we talk about color
Twomey, C. R.; Roberts, G.; Brainard, D. H.; Plotkin, J. B.
10.1101/2020.09.29.319517 — animal behavior and cognition — Posted on 2021-06-07
3201 Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome
Chen, Y.-S.; Lu, S.; Zhang, B.; Du, T.; Li, W.-J.; Lei, M.; Zhou, Y.; Zhang, Y.; Liu, P.; Sun, Y.-Q.; Zhao, Y.-L.; Yang, Y.; Peng, X.; Yang, Y.-G.
10.1101/2021.06.06.447293 — genomics — Posted on 2021-06-07
3205 Droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show slower inner fluidity
Omar, F. M.; Ichimura, Y.; Kageyama, S.; El-Gowily, A. H.; Sou, Y.-s.; Koike, M.; Noda, N. N.; Komatsu, M.
10.1101/2021.06.07.447422 — cell biology — Posted on 2021-06-07
3206 AGNOSTOS-DB: a resource to unlock the uncharted regions of the coding sequence space
Vanni, C.; Schechter, M. S.; Delmont, T. O.; Eren, A. M.; Steinegger, M.; Gloeckner, F. O.; Fernandez-Guerra, A.
10.1101/2021.06.07.447314 — microbiology — Posted on 2021-06-07
3209 Bacterial gasdermins reveal an ancient mechanism of cell death
Johnson, A. G.; Wein, T.; Mayer, M. L.; Duncan-Lowey, B.; Yirmiya, E.; Oppenheimer-Shaanan, Y.; Amitai, G.; Sorek, R.; Kranzusch, P. J.
10.1101/2021.06.07.447441 — microbiology — Posted on 2021-06-07
3210 The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses
Sayed, I. M.; Ibeawuchi, S.-R.; Lie, D.; Anandachar, M. S.; Pranadinata, R.; Raffatellu, M.; Das, S.
10.1101/2021.06.07.447447 — microbiology — Posted on 2021-06-07
3211 B.1.1.7 and B.1.351 variants are highly virulent in K18-ACE2 transgenic mice and show different pathogenic patterns from early SARS-CoV-2 strains
Radvak, P.; Kwon, H. J.; Kosikova, M.; Ortega-Rodriguez, U.; Xiang, R.; Phue, J.-N.; Shen, R.-F.; Rozzelle, J.; Kapoor, N.; Rabara, T.; Fairman, J.; Xie, H.
10.1101/2021.06.05.447221 — immunology — Posted on 2021-06-07
3214 A severe form of maternal separation in rat consisting of nineteen-day 6-hour daily separation at unpredictable times minimally affects behavior across the lifespan
Behring, T. B.; Kyle, M. H.; Hussain, M.; Zhang, J. Y.; Manganaro, A.; Kaidbey, J. H.; Ludwig, R. J.; Myers, M. M.; Welch, M. G.; Dumitriu, D.
10.1101/2021.06.07.447289 — neuroscience — Posted on 2021-06-07
3215 PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7 to suppress p53 dependent neurodegeneration
Huo, Y.; Sawant, A.; Tan, Y.; Mahdi, A. H.; Li, T.; Ma, H.; Bhatt, V.; Yan, R.; Coleman, J.; Dreyfus, C. F.; Guo, J. Y.; Mouradian, M. M.; White, E.; Xia, B.
10.1101/2021.06.07.447248 — neuroscience — Posted on 2021-06-07
3216 Reducing susceptibility distortion related image blurring in diffusion MRI EPI data
Clark, I. A.; Callaghan, M. F.; Weiskopf, N.; Maguire, E. A.; Mohammadi, S.
10.1101/2021.06.07.447406 — neuroscience — Posted on 2021-06-07
3218 Dorsal striatal dopamine induces fronto-cortical hypoactivity and implies reduced anxiety and compulsive behaviors in rats
Casado-Sainz, A.; Gudmundsen, F.; Baerentzen, S. L.; Lange, D.; Ringsted, A.; Martinez-Tajada, I.; Medina, S.; Lee, H.; Svarer, C.; Keller, S. H.; Schain, M.; Kjaerby, C.; Fisher, P. M.; Cumming, P.; Palner, M.
10.1101/2021.02.11.430770 — neuroscience — Posted on 2021-06-07
3227 Characterizing Human Mesenchymal Stromal Cells Immune Modulatory Potency Using Targeted Lipidomic Profiling of Sphingolipids
DeVeaux, S. A.; Ogle, M. E.; Vyshnya, S.; Chiappa, N. F.; Leitmann, B.; Rudy, R.; Day, A.; Mortensen, L. J.; Kurtzberg, J.; Roy, K.; Botchwey, E.
10.1101/2021.06.01.446428 — bioengineering — Posted on 2021-06-07
3228 Bioelectromagnetic platform for stimulation
Ashbaugh, R. C.; Udpa, L.; Israeli, R. R.; Gilad, A. A.; Pelled, G.
10.1101/2021.06.07.447412 — bioengineering — Posted on 2021-06-07
3230 The breast pre-cancer atlas illustrates the molecular and micro-environmental diversity of ductal carcinoma in situ
Nachmanson, D.; Officer, A.; Mori, H.; Gordon, J.; Evans, M. F.; Steward, J.; Yao, H.; O'Keefe, T.; Hasteh, F.; Stein, G. S.; Jepsen, K.; Weaver, D. L.; Hirst, G.; Sprague, B. L.; Esserman, L. J.; Borowsky, A. D.; Stein, J. L.; Harismendy, O.
10.1101/2021.05.11.443641 — genomics — Posted on 2021-06-07
3231 Pioneer activity of an oncogenic fusion transcription factor at inaccessible chromatin
Sunkel, B.; Wang, M.; LaHaye, S.; Kelly, B. J.; Fitch, J. R.; Barr, F. G.; White, P.; Stanton, B. Z.
10.1101/2020.12.11.420232 — genomics — Posted on 2021-06-07
3233 SmMIP-tools: a computational toolset for processing and analysis of single-molecule molecular inversion probes derived data
Medeiros, J. J. F.; Capo-Chichi, J.-M.; Shlush, L. I.; Dick, J. E.; Arruda, A.; Minden, M. D.; Abelson, S.
10.1101/2021.06.03.446993 — genomics — Posted on 2021-06-07
3237 Super-human cell death detection with biomarker-optimized neural networks
Linsley, J. W.; Linsley, D.; Lamstein, J.; Ryan, G.; Shah, K.; Castello, N. A.; Oza, V.; Kalra, J.; Wang, S.; Tokuno, Z.; Javaherian, A.; Serre, T.; Finkbeiner, S.
10.1101/2020.08.04.237032 — cell biology — Posted on 2021-06-07
3240 Auto-qPCR: A Python based web app for automated and reproducible analysis of qPCR data
Maussion, G.; Thomas, R. A.; Demirova, I.; Gu, G.; Cai, E.; Chen, C. X.- Q.; Abdian, N.; Strauss, T. J. P.; Kelai, S.; Nauleau Javaudin, A.; Beitel, L. K.; Ramoz, N.; Gorwood, P.; Durcan, T. M.
10.1101/2021.01.14.426748 — molecular biology — Posted on 2021-06-07
3242 Distinctive properties of cones in the retinal clock and the circadian system
Sandu, C.; Wongchitrat, P.; Mazzaro, N.; Jaeger, C.; Calligaro, H.; Mendoza, J.; Hicks, D.; Felder-Schmittbuhl, M.-P.
10.1101/2020.09.15.297879 — neuroscience — Posted on 2021-06-07
3247 Precision neoantigen discovery using large-scale immunopeptidomes and composite modeling of MHC peptide presentation
Pyke, R. M.; Mellacheruvu, D.; Dea, S.; Abbott, C.; Zhang, S. V.; Phillips, N. A.; Harris, J.; Bartha, G.; Desai, S.; McClory, R.; West, J.; Snyder, M. P.; Chen, R.; Boyle, S. M.
10.1101/2021.04.30.442203 — bioinformatics — Posted on 2021-06-07
3248 Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex
Codeluppi, S. A.-M.; Chatterjee, D.; Prevot, T. D.; Bansal, Y.; Misquitta, K. A.; Sibille, E.; Banasr, M.
10.1101/2021.02.23.432559 — animal behavior and cognition — Posted on 2021-06-07
3252 Analysis of microvascular thrombus mechanobiology with a novel particle-based model
Masalceva, A. A.; Kaneva, V. N.; Panteleev, M. A.; Ataullahanov, F.; Volpert, V.; Afanasyev, I.; Nechipurenko, D. Y.
10.1101/2021.06.07.447380 — biophysics — Posted on 2021-06-07
3258 Hypoxia is a dominant remodeler of the CD8+ T cell surface proteome relative to activation and regulatory T cell-mediated suppression
Byrnes, J. R.; Weeks, A. M.; Carnevale, J.; Shifrut, E.; Kirkemo, L.; Ashworth, A.; Marson, A.; Wells, J. A.
10.1101/2021.06.07.447379 — immunology — Posted on 2021-06-07
3259 Mitochondria decode firing frequency and coincidences of postsynaptic APs and EPSPs
Stoler, O.; Stavsky, A.; Khrapunsky, Y.; Melamed, I.; Stutzmann, G.; Gitler, D.; Sekler, I.; Fleidervish, I.
10.1101/2021.06.07.447340 — neuroscience — Posted on 2021-06-07
3260 Treadmill exercise promotes retinal astrocyte plasticity and protects against retinal degeneration
Bales, K. L.; Chacko, A. S.; Nickerson, J. M.; Pardue, M. T.; Boatright, J. H.; Pardue, M.
10.1101/2021.06.07.447392 — neuroscience — Posted on 2021-06-07
3264 Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis
Klemm, F.; Schaeffer, A.; Salamero-Boix, A.; Alekseeva, T.; Schulz, M.; Niesel, K.; Maas, R. R.; Groth, M.; Elie, B. T.; Bowman, R. L.; Hegi, M. E.; Daniel, R. T.; Zeiner, P. S.; Zinke, J.; Harter, P. N.; Plate, K. H.; Joyce, J. A.; Sevenich, L.
10.1101/2021.06.07.447034 — cancer biology — Posted on 2021-06-07
3265 HistoClean: Open-source Software for Histological Image Pre-processing and Augmentation to Improve Development of Robust Convolutional Neural Networks
McCombe, K. D.; Craig, S. G.; Pulsawatdi, A. V.; Quezada-Marin, J. I.; Hagan, M.; Rajendran, S.; Humphries, M. P.; Bingham, V.; Salto-Tellez, M.; Gault, R.; James, J. A.
10.1101/2021.06.07.447339 — cancer biology — Posted on 2021-06-07
3268 Towards a Comprehensive Variation Benchmark for Challenging Medically-Relevant Autosomal Genes
Wagner, J.; Olson, N. D.; Harris, L.; McDaniel, J.; Cheng, H.; Fungtammasan, A.; Hwang, Y.-C.; Gupta, R.; Wenger, A. M.; Rowell, W. J.; Khan, Z. M.; Farek, J.; Zhu, Y.; Pisupati, A.; Mahmoud, M.; Xiao, C.; Yoo, B.; Sahraeian, S. M. E.; Miller, D. E.; Jaspez, D.; Lorenzo-Salazar, J. M.; Munoz-Barrera, A.; Rubio-Rodriguez, L. A.; Flores, C.; Narzisi, G.; Evani, U. S.; Clarke, W. E.; Lee, J.; Mason, C. E.; Lincoln, S. E.; Miga, K. H.; Ebbert, M. T.; Shumate, A.; Li, H.; Chin, C.-S.; Zook, J. M.; Sedlazeck, F. J.
10.1101/2021.06.07.444885 — genomics — Posted on 2021-06-07
3269 Cell-specific chromatin landscape of human coronary artery resolves regulatory mechanisms of disease risk
Turner, A. W.; Hu, S.; Verdezoto Mosquera, J.; Ma, W. F.; Hodonsky, C.; Wong, D.; Auguste, G.; Sol-Church, K.; Farber, E. A.; Kundu, S.; Kundaje, A. B.; Lopez, N. G.; Ma, L.; Ghosh, S. K. B.; Onengut-Gumuscu, S.; Ashley, E. A.; Quertermous, T.; Finn, A. V.; Leeper, N. J.; Kovacic, J. C.; Bjorkegren, J. L. M.; Zang, C.; Miller, C. L.
10.1101/2021.06.07.447388 — genomics — Posted on 2021-06-07
3270 Natural variation in the irld gene family affects insulin/IGF signaling and starvation resistance
Webster, A. K.; Chitrakar, R.; Powell, M.; Chen, J.; Fisher, K.; Tanny, R.; Stevens, L.; Evans, K.; Antoshechkin, I.; Andersen, E. C.; Baugh, L. R.
10.1101/2021.06.07.447366 — genetics — Posted on 2021-06-07
3272 Core and indicative bacterial and fungal taxa define characteristic soil communities of arable land, grassland, and forest
Gschwend, F.; Hartmann, M.; Mayerhofer, J.; Hug, A.; Enkerli, J.; Gubler, A.; Meuli, R. G.; Frey, B.; Widmer, F.
10.1101/2021.06.07.447343 — ecology — Posted on 2021-06-07
3275 Hepatic miR-20b promotes nonalcoholic fatty liver disease by suppressing PPARα
Lee, Y. H.; Jang, H.-J.; Kim, S.; Choi, S. S.; Khim, K. W.; Eom, H.-J.; Hyun, J.; Shin, K. J.; Chae, Y. C.; Kim, H.; Park, J.; Park, N. H.; Woo, C.-Y.; Hong, C. H.; Koh, E. H.; Nam, D.; Choi, J. h.
10.1101/2021.06.07.447348 — molecular biology — Posted on 2021-06-07
3276 Salt-inducible kinase (SIK) inhibition is protective in a mouse model of asthma
van Gijsel-Bonnello, M.; Darling, N. J.; McDonald, L.; Sime, M.; Clark, J.; Mezna, M.; Schuettelkopf, A.; Mackay, C.; Bower, J.; McKinnon, H.; Cohen, P.; Arthur, S.
10.1101/2021.06.07.447230 — immunology — Posted on 2021-06-07
3282 TRIB1 regulates tumour growth via controlling tumour-associated macrophage phenotypes and is associated with breast cancer survival and treatment response
Kim, T.; Johnston, J.; Felipe, F. J. C.; Hamby, S.; Castillo-Lluva, S.; The Cardiogenics Consortium, ; Goodall, A. H.; Velasco, G.; Ocana, A.; Muthana, M.; Kiss-Toth, E.
10.1101/2021.06.07.446596 — cancer biology — Posted on 2021-06-07
3288 FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome
Brevini, T.; Maes, M.; Webb, G. J.; Gelson, W. T. H.; Forrest, S.; Mlcochova, P.; Dillon, S.; Varankar, S.; Darvish-Damavandi, M.; Mulcahy, V. L.; Kuc, R. E.; Williams, T. L.; Galanakis, V.; Vila-Gonzalez, M.; Tysoe, O. C.; Muraro, D.; Crozier, T. W. M.; Bargehr, J.; Sinha, S.; Upponi, S. S.; Swift, L.; Saeb-Parsy, K.; Davies, S. E.; Marjot, T.; Barnes, E.; Lohse, A. W.; Moon, A. M.; Barritt, S. A.; Gupta, R. K.; Baker, S.; Davenport, A. P.; Corbett, G.; Buczacki, S. J. A.; Lee, J.-H.; Gibbs, P.; Butler, A. J.; Watson, C. J. E.; Mells, G. F.; Dougan, G.; vallier, L.; Sampaziotis, F.
10.1101/2021.06.06.446781 — microbiology — Posted on 2021-06-07
3289 Neutralization against B.1.351 and B.1.617.2 with sera of COVID-19 recovered cases and vaccinees of BBV152
Yadav, P. D.; Sapkal, G.; Ella, R.; Sahay, R. R.; Nyayanit, D. A.; Patil, D. Y.; Deshpande, G.; Shete, A. M.; Gupta, N.; Mohan, V. K.; Abraham, P.; Panda, S.; Bhargava, B.
10.1101/2021.06.05.447177 — microbiology — Posted on 2021-06-07
3290 A Web Portal and Workbench for Biological Dissection of Single Cell COVID-19 Host Responses
Jin, K.; Bardes, E. E.; Mitelpunkt, A.; Wang, Y. J.; Bhatnagar, S.; Sengupta, S.; Krummel, D. P.; Rothenberg, M. E.; Aronow, B. J.
10.1101/2021.06.07.447287 — immunology — Posted on 2021-06-07
3295 Natural selection promotes the evolution of recombination 1: among selected genotypes
Gerrish, P. J.; Galeota-Sprung, B. J.; Sniegowski, P. D.; Chevallier, J.; Ycart, B.
10.1101/2021.06.07.447320 — evolutionary biology — Posted on 2021-06-07
3296 Natural selection promotes the evolution of recombination 2: during the selective process
Gerrish, P. J.; Cordero, F.; Galeota-Sprung, B.; Colato, A.; Vejalla, V.; Sniegowski, P. D.
10.1101/2021.06.07.447324 — evolutionary biology — Posted on 2021-06-07
3300 Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs
Schooley, R. T.; Carlin, A. F.; Beadle, J. R.; Valiaeva, N.; Zhang, X.-Q.; Clark, A. E.; McMillian, R. E.; Leibel, S. L.; McVicar, R. N.; Xie, J.; Garretson, A. F.; Smith, V. I.; Murphy, J. A.; Hostetler, K. Y.
10.1101/2020.08.26.269159 — microbiology — Posted on 2021-06-07
3304 DsbA is a redox-switchable mechanical chaperone
Eckels, E. C.; Chaudhuri, D.; Chakraborty, S.; Echelman, D. J.; Haldar, S.
10.1101/310169 — biophysics — Posted on 2021-06-07
3306 Genomic Surveillance of COVID-19 Variants with Language Models and Machine Learning
Nagpal, S.; Pal, R.; Ashima, ; Tyagi, A.; Tripathi, S.; Nagori, A.; Ahmad, S.; Mishra, H. P.; Kutum, R.; Sethi, T.
10.1101/2021.05.25.445601 — bioinformatics — Posted on 2021-06-07
3308 Linking Parasitism to Network Centrality and the Impact of Sampling Bias in its Interpretation
XU, Z.; MacIntosh, A. J. J.; Castellano-Navarro, A.; Macanas-Martuinez, E.; Suzumura, T.; Duboscq, J.
10.1101/2021.06.07.447302 — animal behavior and cognition — Posted on 2021-06-07
3310 Resource-efficient pooled sequencing expands translational impact in solid tumors
DiNatale, R. G.; Mano, R.; Makarov, V.; Rusk, N.; Drill, E.; Winer, A.; Sankin, A.; Yoo, A.; Freeman, B. A.; Hsieh, J. J.; Chen, Y.-B.; Coleman, J. A.; Berger, M. G.; Ostrovnaya, I.; Chan, T. A.; Russo, P.; Reznik, E.; Hakimi, A. A.
10.1101/2021.06.06.447265 — genomics — Posted on 2021-06-07
3311 Insulin is expressed by enteroendocrine cells during human fetal development
Egozi, A.; Llivichuzhca-Loja, D.; McCourt, B.; Farack, L.; An, X.; Wang, F.; Chen, K.; Konnikova, L.; Itzkovitz, S.
10.1101/2021.06.07.447234 — developmental biology — Posted on 2021-06-07
3313 5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes
Liu, M.; Guo, G.; Qian, P.; Mu, J.; Lu, B.; He, X.; Shang, X.; Yang, G.; Shen, S.; Liu, W.; Wang, L.; Gu, L.; Mu, Q.; Yu, X.; Zhao, Y.; Culleton, R.; Cao, J.; Jiang, L.; Wellems, T. E.; Yuan, J.; Jiang, C.; Zhang, Q.
10.1101/2021.06.06.447275 — microbiology — Posted on 2021-06-07
3314 Mutualistic interactions between B. subtilis and seeds dictate plant development
Berlanga-Clavero, M. V.; Molina-Santiago, C.; Caraballo-Rodriguez, A. M.; Petras, D.; Diaz-Martinez, L.; Perez-Garcia, A.; de Vicente, A.; Dorrestein, P.; Romero, D.
10.1101/2021.06.07.447311 — microbiology — Posted on 2021-06-07
3318 Microglial CX3CR1I249/M280 variant limits neurogenesis and remyelination in cuprizone-induced multiple sclerosis model
Mendiola, A. S.; Church, K. A.; Cardona, S. M.; Vanegas, D.; Garcia, S. A.; Macklin, W.; Lira, S. A.; Ransohoff, R. M.; Kokovay, E.; Lin, C.-H. A.; Cardona, A. E.
10.1101/2021.06.06.447262 — neuroscience — Posted on 2021-06-07
3328 Dice-XMBD: Deep learning-based cell segmentation for imaging mass cytometry
Xiao, X.; Qiao, Y.; Jiao, Y.; Fu, N.; Yang, W.; Wang, L.; Yu, R.; Han, J.
10.1101/2021.06.05.447183 — bioinformatics — Posted on 2021-06-07
3331 OrtSuite - from genomes to prediction of microbial interactions within targeted ecosystem processes
Saraiva, J. P.; Bartholomäus, A.; Kallies, R.; Gomes, M.; Fleming Bicalho, M. V.; Vogt, C.; Chatzinotas, A.; Stadler, P. F.; Dias, O.; Nunes da Rocha, U.
10.1101/2021.06.04.447094 — bioinformatics — Posted on 2021-06-07
3332 spicyR: Spatial analysis of in situ cytometry data in R
Canete, N. P.; Iyengar, S. S.; Ormerod, J. T.; Harman, A. N.; Patrick, E.
10.1101/2021.06.07.447307 — bioinformatics — Posted on 2021-06-07
3334 TSEBRA: Transcript Selector for BRAKER
Gabriel, L.; Hoff, K. J.; Bruna, T.; Borodovsky, M.; Stanke, M.
10.1101/2021.06.07.447316 — bioinformatics — Posted on 2021-06-07
3340 Spatial-ATAC-seq: spatially resolved chromatin accessibility profiling of tissues at genome scale and cellular level
Deng, Y.; Bartosovic, M.; Ma, S.; Zhang, D.; Liu, Y.; Qin, X.; Su, G.; Xu, M. L.; Halene, S.; Craft, J. E.; Castelo-Branco, G.; Fan, R.
10.1101/2021.06.06.447244 — genomics — Posted on 2021-06-07
3342 A single amino acid in RTEL1 determines telomere length in mice
Smoom, R.; Lee May, C.; Kolev, H.; Reizel, Y.; Morgan, A.; Kaestner, K. H.; Tzfati, Y.
10.1101/2021.06.06.447246 — genetics — Posted on 2021-06-07
3343 DNA transposon expansion is associated with genome size increase in mudminnows
Lehmann, R.; Kovarik, A.; Ocalewicz, K.; Kirtiklis, L.; Zuccolo, A.; Tegner, J. N.; Wanzenboeck, J.; Bernatchez, L.; Lamatsch, D.; Symonova, R.
10.1101/2021.06.07.447207 — evolutionary biology — Posted on 2021-06-07
3348 Selective pharmaceutical inhibition of PARP14 mitigates allergen-induced IgE and mucus overproduction in a mouse model of pulmonary allergic response
Eddie, A. M.; Schenkel, L. B.; Swinger, K. K.; Molina, J. R.; Kunii, K.; Raybuck, A. L.; Keilhack, H.; Niepel, M.; Peebles, R. S.; Boothby, M. R.; Cho, S. H.
10.1101/2021.06.05.447208 — immunology — Posted on 2021-06-07
3350 Postnatal lymph node expansion of stromal progenitors towards reticular and CD34+ stromal cell subsets is determined by distinct transcriptional programs
Pezoldt, J.; Wiechers, C.; Litovchenko, M.; Biocanin, M.; Zou, M.; Sitnik, K.; Beckstette, M.; Chen, W.; Gardeux, V.; Floess, S.; Ebel, M.; Russeil, J.; Arampatzi, P.; Vafardanejad, E.; Saliba, A.-E.; Deplancke, B.; Huehn, J.
10.1101/2021.06.06.447189 — immunology — Posted on 2021-06-07
3355 Adaptable and Automated Rodent Behavior Maze System
Olson, J. M.; Leppla, C. A.; Bladon, J. H.; Jadhav, S. P.
10.1101/2021.06.05.447225 — neuroscience — Posted on 2021-06-07
3357 Enrichment analysis of GWAS data in autoimmunity delineates the multiple sclerosis-Epstein Barr virus association
Mechelli, R.; Umeton, R.; Rinaldi, V.; Bellucci, G.; Bigi, R.; Angelini, D. F.; Guerrera, G.; Srinivasan, S.; Romano, S.; Buscarinu, M. C.; Pizzolato Umeton, F.; Anastasiadou, E.; Trivedi, P.; Fornasiero, A.; Ferraldeschi, M.; IMSGC and WTCCC2, ; Centonze, D.; Uccelli, A.; Di Silvestre, D.; Mauri, P.; de Candia, P.; Matarese, G.; D'Alfonso, S.; Battistini, L.; Farina, C.; Magliozzi, R.; Reynolds, R.; Salvetti, M.; Ristori, G.
10.1101/2021.06.06.447253 — neuroscience — Posted on 2021-06-07
3358 Reporting amyloid beta levels via bioluminescence imaging with amyloid reservoirs inAlzheimer's disease models
Yang, J.; Ding, W.; Zhu, B.; Zhen, S.; Kuang, S.; Zhang, C. M.; Wang, P.; Yang, F.; Yang, L.; Yin, W.; Tanzi, R.; Shen, S.; Ran, C.
10.1101/2021.06.05.447217 — neuroscience — Posted on 2021-06-07
3361 Lack of Age-related Respiratory Changes in Daphnia
Anderson, C. E.; Ekwudo, M. N.; Jonas-Closs, R. A.; Cho, Y.; Peshkin, L. M.; Kirschner, M. W.; Yampolsky, L. Y.
10.1101/2021.06.05.447222 — physiology — Posted on 2021-06-07
3362 Behavioral effects of ethanol in the Red Swamp Crayfish(Procambarus clarkii)
Gutierrez, A.; Creehan, K. M.; de Guglielmo, G.; Roberts, A. J. A.; Taffe, M. A.
10.1101/2021.06.05.447220 — pharmacology and toxicology — Posted on 2021-06-07
3363 Revealing A-T and G-C Hoogsteen base pairs in stressed protein-bound duplex DNA
Shi, H.; Kimsey, I.; Liu, H.-F.; Pham, U.; Schumacher, M.; Al-Hashimi, H.
10.1101/2021.06.05.447203 — biophysics — Posted on 2021-06-07
3365 An accurate assignment test for extremely low-coverage whole-genome sequence data
Ferrari, G.; Atmore, L. M.; Jentoft, S.; Jakobsen, K. S.; Makowiecki, D.; Barrett, J. H.; Star, B.
10.1101/2021.06.04.447098 — bioinformatics — Posted on 2021-06-07
3377 Mapping tree species for restoration potential resilient to climate change
van Tiel, N.; Lyu, L.; Fopp, F.; van den Hoogen, J.; Karger, D. N.; Zimmermann, N. E.; Crowther, T. W.; Pellissier, L.
10.1101/2021.06.04.447113 — ecology — Posted on 2021-06-07
3378 Comparison of bacterial communities from the surface and adjacent bottom layers water of Billings reservoir
Marcondes, M. A.; Nascimento, A.; Pessoa, R.; Victor, J. R.; Silva Duarte, A. J. d.; Sanabani, S. S.
10.1101/2021.06.03.447016 — microbiology — Posted on 2021-06-07
3379 Depletion of TAX1BP1 amplifies innate immune responses during respiratory syncytial virus infection
Descamps, D.; Peres de Oliveira, A.; Gonnin, L.; Madrieres, S.; Fix, J.; Drajac, C.; Marquant, Q.; Bouguyon, E.; Pietralunga, V.; Iha, H.; Morais Ventura, A.; Tangy, F.; Vidalain, P.-O.; Eleouët, J.-F.; Galloux, M.
10.1101/2021.06.03.447014 — microbiology — Posted on 2021-06-07
3380 Depth of sedation with dexmedetomidine modulates cortical excitability non-linearly
Cardone, P.; Bodart, O.; Kirsch, M.; Sanfilippo, J.; Virgilitto, A.; Martial, C.; Simon, J.; Wannez, S.; Sanders, R. D.; Laureys, S.; Massimini, M.; Bonhomme, V.; Gosseries, O.
10.1101/2021.06.04.447060 — neuroscience — Posted on 2021-06-07
3381 COBREXA.jl: constraint-based reconstruction and exascale analysis
Kratochvil, M.; Heirendt, L.; Wilken, S. E.; Pusa, T.; Arreckx, S.; Noronha, A.; van Aalst, M.; Satagopam, V. P.; Ebenhoeh, O.; Schneider, R.; Trefois, C.; Gu, W.
10.1101/2021.06.04.447038 — systems biology — Posted on 2021-06-07
3382 STENCIL: A web templating engine for visualizing and sharing life science datasets
Sun, Q.; Nematbakhsh, A.; Kuntala, P. K.; Kellogg, G.; Pugh, B. F.; Lai, W.
10.1101/2021.06.04.447108 — bioinformatics — Posted on 2021-06-07
3383 Limits and potential of combined folding and docking using PconsDock.
Pozzati, G.; Zhu, W.; Lamb, J.; Bassot, C.; Kundrotas, P.; Elofsson, A.
10.1101/2021.06.04.446442 — bioinformatics — Posted on 2021-06-07
3385 Transcriptome analysis and connectivity mapping of Cissampelos pareira L. provides molecular links of ESR1 modulation to viral inhibition
Haider, M.; Dholakia, D.; Panwar, A.; Garg, P.; Gheware, A. P.; Singhal, K.; Singh, D.; Burse, S. A.; Kumari, S.; Kumar, A.; Ray, A.; Medigeshi, G. R.; Sharma, U.; Prasher, B.; Mukerji, M.
10.1101/2021.02.17.431579 — genomics — Posted on 2021-06-07
3386 Consumers' active choice behavior promotes coevolutionary units
Alvarenga, A. M. S. B. d.; Borges, M. E.; Jorge, L. R.; Varassin, I. G.; Araujo, S. B. L.
10.1101/2021.06.04.446921 — ecology — Posted on 2021-06-07
3388 Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant
Thorne, L. G.; Bouhaddou, M.; Reuschl, A.-K.; Zuliani-Alvarez, L.; Polacco, B. J.; Pelin, A.; Batra, J.; Whelan, M. V. X.; Ummadi, M.; Roic, A.; Turner, J.; Obernier, K.; Braberg, H.; Soucheray, M.; Richards, A. L.; Chen, K.-H.; Harjai, B.; Memon, D.; Hosmillo, M.; Hiatt, J.; Jahun, A. S.; Goodfellow, I. G.; Noursadeghi, M.; Fabius, J.; Shokat, K.; Jura, N.; Verba, K. A.; Beltrao, P.; Swaney, D. L.; Garcia-Sastre, A.; Jolly, C.; Towers, G. J.; Krogan, N. J.
10.1101/2021.06.06.446826 — microbiology — Posted on 2021-06-07
3390 Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease
Scarneo, S.; Smith, A.; Favret, J.; O'connell, R.; Pickeral, J.; Yang, K.; Ferrari, G.; Loiselle, D.; Hughes, P.; Kulkarni, M.; Gargesha, M.; Scott, B.; Roy, D.; Haynes, B.; Kweik, J.; Haystead, T.
10.1101/2021.06.06.446823 — pharmacology and toxicology — Posted on 2021-06-07
3393 Natural selection and the advantage of recombination
Gerrish, P. J.; Galeota-Sprung, B.; Cordero, F.; Sniegowski, P. D.; Colato, A.; Hengartner, N. W.; Vejalla, V.; Chevalier, J.; Ycart, B.
10.1101/2020.08.28.271486 — evolutionary biology — Posted on 2021-06-07
3394 Heme oxygenase-2 (HO-2) binds and buffers labile heme, which is largely oxidized, in human embryonic kidney cells
Hanna, D. A.; Moore, C. M.; Liu, L.; Yuan, X.; Fleischhacker, A. S.; Hamza, I.; Ragsdale, S. W.; Reddi, A. R.
10.1101/2021.06.06.447256 — cell biology — Posted on 2021-06-07
3395 Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies
Diaz-Pascual, F.; Lempp, M.; Nosho, K.; Jeckel, H.; Jo, J. K.; Neuhaus, K.; Hartmann, R.; Jelli, E.; Hansen, M. F.; Price-Whelan, A.; Dietrich, L. E. P.; Link, H.; Drescher, K.
10.1101/2021.02.28.433255 — microbiology — Posted on 2021-06-07
3396 Chained structure of dimeric F1-like ATPase in Mycoplasma mobile gliding machinery
Toyonaga, T.; Kato, T.; Kawamoto, A.; Kodera, N.; Hamaguchi, T.; Tahara, Y. O.; Ando, T.; Namba, K.; Miyata, M.
10.1101/2021.04.06.438750 — microbiology — Posted on 2021-06-07
3399 Changing the social brain: plasticity along macro-scale axes of functional connectivity following social mental training.
Valk, S. L.; Kanske, P.; Park, B.-y.; Hong, S.-J.; Boeckler-Raettig, A.; Trautwein, F.-M.; Bernhardt, B. C.; Singer, T.
10.1101/2020.11.11.377895 — neuroscience — Posted on 2021-06-07
3403 Naturalized Dolichogenidea gelechiidivoris Marsh (Hymenoptera: Braconidae) complement the resident parasitoid complex of Tuta absoluta (Meyrick) (Lepidopera:Gelechiidae) in Spain
Denis, C.; RIUDAVETS, J.; ALOMAR, O.; AGUSTI, N.; GONZALEZ-VALERO, H.; CUBI, M.; MATAS, M.; RODRIGUEZ, D.; VAN ACHTERBERG, K.; ARNO, J.
10.1101/2021.05.27.445932 — ecology — Posted on 2021-06-07
3404 Structural insights into the modes of relaxin-binding and tethered-agonist activation of RXFP1 and RXFP2
Sethi, A.; Bruell, S.; Ryan, T.; Yan, F.; Tanipour, M. H.; Mok, Y. F.; Joyce, C. D.; Khandokar, Y.; Metcalfe, R. D.; Griffin, M. D. W.; Scott, D. J.; Hossain, M. A.; Petrie, E. J.; Bathgate, R. A. D.; Gooley, P. R.
10.1101/2021.06.06.446989 — biophysics — Posted on 2021-06-07
3410 Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers
Louros, N. N.; Ramakers, M.; Michiels, E.; Konstantoulea, K.; Morelli, C.; Garcia, T.; D'Haeyer, S.; Goossens, V.; Audenaert, D.; Rousseau, F.; Schymkowitz, J.
10.1101/2021.06.04.447096 — biophysics — Posted on 2021-06-06
3413 Single-cell RNA-sequencing reveals widespread personalized, context-specific gene expression regulation in immune cells.
Oelen, R.; de Vries, D. H.; Brugge, H.; Gordon, G.; Vochteloo, M.; Ye, C. J.; Westra, H.-J.; Franke, L.; van der Wijst, M. G. P.
10.1101/2021.06.04.447088 — genetics — Posted on 2021-06-06
3418 Influence of the metallized coils on human leg blood circulation
Dehtjars, J.; Jasina, K.; Larins, V.; Okss, A.; Pudovskis, K.; Tolmaca, N.; Vadhiraj, V. V.
10.1101/2021.06.04.447146 — biophysics — Posted on 2021-06-06
3420 In-depth sequence-function characterization reveals multiple paths to enhance phenylalanine ammonia-lyase (PAL) activity.
Trivedi, V. D.; Chappell, T. C.; Krishna, N. B.; Shetty, A.; Sigamani, G. G.; Mohan, K.; Ramesh, A. S.; Kumar R., P.; Nair, N. U.
10.1101/2021.06.06.447205 — bioengineering — Posted on 2021-06-06
3421 Glyoxal as alternative fixative for single cell RNA sequencing
Bageritz, J.; Krausse, N.; Yousefian, S.; Leible, S.; Valentini, E.; Boutros, M.
10.1101/2021.06.06.447272 — genomics — Posted on 2021-06-06
3422 Airborne bacteria over oceans shed light on global biogeodiversity patterns
Lang-Yona, N.; Flores, J. M.; Haviv, R.; Alberti, A.; Poulain, J.; Belser, C.; Trainic, M.; Gat, D.; Ruscheweyh, H. J.; Wincker, P.; Sunagawa, S.; Rudich, Y.; Koren, I.; Vardi, A.
10.1101/2021.06.06.445733 — ecology — Posted on 2021-06-06
3423 Revealing the full biosphere structure and versatile metabolic functions in the deepest ocean sediment of the Challenger Deep
Chen, P.; Zhou, H.; Huang, Y.; Xie, Z.; Zhang, M.; Wei, Y.; Li, J.; Ma, Y.; Luo, M.; Ding, W.; Cao, J.; Jiang, T.; Nan, P.; Fang, J.; Li, X.
10.1101/2021.06.05.447043 — microbiology — Posted on 2021-06-06
3424 Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections
Heemskerk, M. T.; Korbee, C. J.; Esselink, J.; Carvalho dos Santos, C.; van Veen, S.; Gordijn, I. F.; Vrieling, F.; Walburg, K. V.; Engele, C. G.; Dijkman, K.; Wilson, L.; Verreck, F. A.; Haks, M. C.; Ottenhoff, T. H.
10.1101/2021.06.05.447191 — immunology — Posted on 2021-06-06
3425 Microstructural development across white matter from 9-13 years
Palmer, C. E.; Pecheva, D.; Iversen, J. R.; Hagler, D. J.; Sugrue, L.; Nedelec, P.; Fan, C.; Thompson, W.; Jernigan, T. L.; Dale, A. M.
10.1101/2021.06.04.447102 — neuroscience — Posted on 2021-06-06
3428 Evolutionary tracking of cancer haplotypes at single-cell resolution
Williams, M. J.; Funnell, T.; O'Flanagan, C.; McPherson, A.; Salehi, S.; Vazquez-Garcia, I.; Kabeer, F.; Lee, H.; Masud, T.; Eirew, P.; Yap, D.; Wang, B.; Brimhall, J.; Biele, J.; Ting, J.; Beatty, S.; Lai, D.; Pham, J.; Grewel, D.; Abrams, D.; Havasov, E.; Leung, S.; Bojilova, V.; Weiner, A. C.; Rusk, N.; Uhlitz, F.; Ceglia, N.; Consortium, I.; Aparicio, S.; Shah, S. P.
10.1101/2021.06.04.447031 — cancer biology — Posted on 2021-06-06
3430 Accurate Virus Identification with Interpretable Raman Signatures by Machine Learning
Ye, J.; Yeh, Y.-T.; Xue, Y.; Wang, Z.; Zhang, N.; Liu, H.; Zhang, K.; Yu, Z.; Roder, A.; Lopez, N. P.; Organtini, L.; Greene, W.; Hafenstein, S.; Lu, H.; Ghedin, E.; Terrones, M.; Huang, S.; Huang, S. X.
10.1101/2021.06.04.446928 — biophysics — Posted on 2021-06-06
3432 Microbiota and stress: a loop that impacts memory
Kraimi, N.; Lormant, F.; Calandreau, L.; Kempf, F.; zemb, o.; Lemarchand, J.; Constantin, P.; Parias, C.; Germain, K.; Dupont, C.; Rabot, S.; Philippe, C.; Foury, A.; Moisan, M.-P.; Carvalho, A.; Coustham, V.; Dardente, H.; Velge, P.; Cousin, P.; Chaumeil, T.; Leterrier, C.
10.1101/2021.06.04.447027 — animal behavior and cognition — Posted on 2021-06-06
3433 Genome-wide reconstruction of rediploidization following autopolyploidizationacross one hundred million years of salmonid evolution
Gundappa, M. K.; To, T.-H.; Gronvold, L.; Martin, S. A. M.; Lien, S.; Geist, J.; Hazlerigg, D.; Sandve, S. R.; Macqueen, D. J.
10.1101/2021.06.05.447185 — genomics — Posted on 2021-06-06
3434 Genome editing in animals with minimal PAM CRISPR-Cas9 enzymes
Vicencio, J.; Sanchez-Bolanos, C.; Moreno-Sanchez, I.; Brena, D.; Kukhtar, D.; Ruiz-Lopez, M.; Cots-Ponjoan, M.; Vejnar, C. E.; Rubio, A.; Rodrigo Melero, N.; Carolis, C.; Perez-Pulido, A. J.; Giraldez, A. J.; Kleinstiver, B. P.; Ceron, J.; Moreno-Mateos, M. A.
10.1101/2021.06.06.447255 — genetics — Posted on 2021-06-06
3440 Multi-omics profiling of Earth's biomes reveals that microbial and metabolite composition are shaped by the environment
Shaffer, J. P.; Nothias, L.-F.; Thompson, L. R.; Jon, S. G.; Salido, R. A.; Couvillion, S. P.; Brejnrod, A. D.; Huang, S.; Lejzerowicz, F.; Lutz, H. L.; Zhu, Q.; Martino, C.; Morton, J. T.; Karthikeyan, S.; Nothias-Esposito, M.; Dührkop, K.; Böcker, S.; Kim, H.; Aksenov, A. A.; Bittremieux, W.; Minich, J. J.; Marotz, C.; Bryant, M. M.; Sanders, K.; Schwartz, T.; Humphrey, G.; Vasquez-Baeza, Y.; Tripathi, A.; Parida, L.; Carrieri, A. P.; Haiminen, N.; Beck, K. L.; Das, P.; Gonzalez, A.; McDonald, D.; Karst, S. M.; Albertsen, M.; Ackermann, G.; DeReus, J.; Thomas, T.; Petras, D.; Shade, A.; St
10.1101/2021.06.04.446988 — ecology — Posted on 2021-06-06
3441 Magnetic Bead-Based Separation (MBS) of Pneumococcal Serotypes
York, A.; Mbodj, S.; Yolda-Carr, D.; Hislop, M.; Weinberger, D. M.; Wyllie, A. L.
10.1101/2021.06.06.447277 — microbiology — Posted on 2021-06-06
3442 Plasmodium falciparum Calcium Dependent Protein Kinase 4 is critical for male gametogenesis and transmission to the mosquito vector
KUMAR, S.; Haile, M. T.; Hoopmann, M. R.; Tran, L. T.; Michaels, S. A.; Morrone, S. R.; Ojo, K. K.; Reynolds, L. M.; Kusebauch, U.; Vaughan, A. M.; Moritz, R. L.; Kappe, S. H. I.; Swearingen, K. E.
10.1101/2021.06.06.447280 — microbiology — Posted on 2021-06-06
3443 Selective retinal ganglion cell loss and optic neuropathy in a humanized mouse model of familial dysautonomia
Chekuri, A. K.; Logan, E. M.; Krauson, A. J.; Salani, M.; Ackerman, S.; Kirchner, E. G.; Bolduc, J. M.; Wang, X.; Dietrich, P.; Dragatsis, I.; Vandenberghe, L. H.; Morini, E.; Slaugenhaupt, S. A.
10.1101/2021.06.04.447086 — neuroscience — Posted on 2021-06-06
3444 Spatially heterogeneous microstructural development within subcortical regions from 9-13 years
Palmer, C. E.; Pecheva, D.; Iversen, J. R.; Hagler, D. J.; Sugrue, L.; Nedelec, P.; Fan, C.; Thompson, W.; Jernigan, T. L.; Dale, A. M.
10.1101/2021.06.04.446984 — neuroscience — Posted on 2021-06-06
3446 Combustible and electronic cigarette exposures increase ACE2 activity and SARS-CoV-2 Spike binding
Ghosh, A.; Girish, V.; Yuan, M. L.; Coakley, R. D.; Alexis, N. E.; Sausville, E. L.; Vasudevan, A.; Chait, A. R.; Sheltzer, J. M.; Tarran, R.
10.1101/2021.06.04.447156 — physiology — Posted on 2021-06-06
3448 Cryo-EM structure of native human thyroglobulin
Adaixo, R.; Steiner, E. M.; Righetto, R. D.; Schmidt, A.; Stahlberg, H.; Taylor, N. M. I.
10.1101/2021.06.06.447243 — biophysics — Posted on 2021-06-06
3449 The biaxial mechanics of thermally denaturing skin - Part II: Modeling
Rausch, M. K.; Meador, W. D.; Toaquiza Tubon, J.; Moreno Flores, O.; Buganza Tepole, A.
10.1101/2021.06.04.447120 — biophysics — Posted on 2021-06-06
3450 Utilizing proteomics and phosphoproteomics to predict ex vivo drug sensitivity across genetically diverse AML patients
Gosline, S. J.; Tognon, C.; Nestor, M.; Joshi, S.; Modak, R.; Damnernsawad, A.; Moon, J.; Hansen, J. R.; Hutchinson-Bunch, C.; Gritsenko, M. A.; Weitz, K. K.; Traer, E.; Drucker, B.; Agarwal, A.; Piehowski, P.; McDermott, J. E.; Rodland, K.
10.1101/2021.06.04.447154 — bioinformatics — Posted on 2021-06-06
3451 Drug Repurposing for the SARS-CoV-2 Papain-Like Protease
Cho, C.-C. D.; Li, S. G.; Yang, K. S.; Lalonde, T. J.; Yu, G.; Qiao, Y.; Xu, S.; Liu, W. R.
10.1101/2021.06.04.447160 — biochemistry — Posted on 2021-06-06
3452 Discovery, diversity and functional associations of crAss-like phages in human gut metagenomes from four Dutch cohorts
Gulyaeva, A.; Garmaeva, S.; Ruigrok, R. A. A. A.; Wang, D.; Riksen, N. P.; Netea, M. G.; Wijmenga, C.; Weersma, R. K.; Fu, J.; Vich Vila, A.; Kurilshikov, A.; Zhernakova, A.
10.1101/2021.06.01.446427 — microbiology — Posted on 2021-06-06
3453 Generative replay for compositional visual understanding in the prefrontal-hippocampal circuit
Schwartenbeck, P.; Baram, A.; Liu, Y.; Mark, S.; Muller, T.; Dolan, R.; Botvinick, M.; Kurth-Nelson, Z.; Behrens, T.
10.1101/2021.06.06.447249 — neuroscience — Posted on 2021-06-06
3458 The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic Hedgehog signalling
Schembs, L.; Willems, A.; Hasenpusch-Theil, K.; Cooper, J. D.; Whiting, K.; Burr, K.; Bostrand, S. M. K.; Selvaraj, B. T.; Chandran, S.; Theil, T.
10.1101/2021.06.06.447245 — developmental biology — Posted on 2021-06-06
3459 Carboxypeptidase E is efficiently secreted and internalized via lysosomes
Armoza-Eilat, S.; Caspi, M.; Shomron, O.; Hirschberg, K.; Rosin-Arbesfeld, R.
10.1101/2021.06.06.447232 — cell biology — Posted on 2021-06-06
3461 Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq
Glaser, L. V.; Steiger, M.; Fuchs, A.; van Boemmel, A.; Einfeldt, E.; Chung, H.-R.; Vingron, M.; Meijsing, S. H.
10.1101/2021.06.04.446899 — genomics — Posted on 2021-06-06
3462 Robust differentiation of human enteroendocrine cells from intestinal stem cells
Zeve, D.; Stas, E.; de Sousa Casal, J.; Mannam, P.; Qi, W.; Yin, X.; Dubois, S.; Shah, M. S.; Syverson, E. P.; Hafner, S.; Karp, J. M.; Carlone, D. L.; Ordovas-Montanes, J.; Breault, D. T.
10.1101/2020.09.21.303990 — developmental biology — Posted on 2021-06-06
3467 Anti-allergic and anti-inflammatory activities of black cumin extracts in in vitro and in vivo model systems
Shaheen, N.; Azam, A.; Ganguly, A.; Anwar, S.; Parvez, M. S. A.; Punyamurtula, U.; Hasan, M. K.
10.1101/2021.06.05.447226 — plant biology — Posted on 2021-06-06
3468 Nature-inspired Circular-economy Recycling (NaCRe) for Proteins: Proof of Concept
Giaveri, S.; Schmitt, A. M.; Roset Julia, L.; Scamarcio, V.; Murello, A.; Cheng, S.; Menin, L.; Ortiz, D.; Patiny, L.; Bolisetty, S.; Mezzenga, R.; Maerkl, S. J.; Stellacci, F.
10.1101/2020.09.23.309799 — biochemistry — Posted on 2021-06-06
3470 HyDrop: droplet-based scATAC-seq and scRNA-seq using dissolvable hydrogel beads
De Rop, F. V.; Ismail, J. N.; Bravo Gonzalez-Blas, C.; Hulselmans, G. J.; Flerin, C. C.; Janssens, J.; Theunis, K.; Christiaens, V. M.; Wouters, J.; Marcassa, G.; de Wit, J.; Poovathingal, S.; Aerts, S.
10.1101/2021.06.04.447104 — genomics — Posted on 2021-06-06
3472 Sustained post-developmental T-bet expression is critical for the maintenance of type 1 innate lymphoid cells in vivo
Schroeder, J.-H.; Roberts, L. B.; Meissl, K.; Lo, J. W.; Hromadova, D.; Hayes, K.; Zabinski, T.; Moreira Heliodoro, C.; Reis, R.; Howard, J. K.; Grencis, R. K.; Neves, J. F.; Strobl, B.; Lord, G. M.
10.1101/2021.06.05.447200 — immunology — Posted on 2021-06-06
3476 Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations
Thorpe, H.; Tourrette, E.; Yahara, K.; Vale, F.; Liu, S.; Oleastro, M.; Alarcon, T.; Perets, T.; Latifi-Navid, S.; Yamaoka, Y.; Martinez-Gonzalez, B.; Karayiannis, I.; Karamitros, T.; Sgouras, D.; Elamin, W.; Pascoe, B.; Sheppard, S.; Ronkainen, J.; Aro, P.; Engstrand, L.; Agreus, L.; Suerbaum, S.; Thorell, K.; Falush, D.
10.1101/2021.06.05.447065 — evolutionary biology — Posted on 2021-06-06
3477 Gene age predicts the transcriptional landscape of sexual morphogenesis in multicellular fungi
Merenyi, Z.; Viragh, M.; Gluck-Thaler, E.; Slot, J. C.; Kiss, B.; Varga, T.; Geosel, A.; Hegedus, B.; Balint, B.; Nagy, L. G.
10.1101/2021.06.04.447176 — evolutionary biology — Posted on 2021-06-06
3479 Targeted anti-BCR-ABL+ ALL therapy may benefit the heart
Kirchhoff, H.; Ricke-Hoch, M.; Wohlan, K.; Pietzsch, S.; Karsli, U.; Erschow, S.; Zweigerdt, R.; Ganser, A.; Eder, M.; Scherr, M.; Hilfiker-Kleiner, D.
10.1101/2021.06.04.447070 — cancer biology — Posted on 2021-06-06
3480 Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential
Paumann-Page, M.; Kienzl, N. F.; Motwani, J.; Bathish, B. B.; Paton, L. N.; Magon, N. J.; Sevcnikar, B.; Furtmueller, P. G.; Traxlmayr, M. W.; Obinger, C.; Eccles, M. R.; Winterbourn, C. C.
10.1101/2021.06.04.447036 — cancer biology — Posted on 2021-06-06
3481 P2X4 Purinergic Receptors as a Therapeutic Target in Aggressive Prostate Cancer
Maynard, J. P.; Lu, J.; Vidal, I.; Hicks, J.; Mummert, L.; Ali, T.; Kempski, R.; Carter, A. M.; Sosa, R.; Peiffer, L. B.; Joshu, C. E.; Lotan, T. L.; De Marzo, A. M.; Sfanos, K. S.
10.1101/2021.06.04.446195 — cancer biology — Posted on 2021-06-06
3482 A landscape of synergistic drug combinations in non-small-cell lung cancer
Nair, N. U.; Greninger, P.; Friedman, A.; Amzallag, A.; Cortez, E.; Sahu, A. D.; Lee, J. S.; Dastur, A.; Egan, R. K.; Murchie, E.; Crowther, G. S.; McClanaghan, J.; Boisvert, J.; Damon, L.; Ho, J.; Tam, A.; Garnett, M. J.; Engelman, J. A.; Haber, D. A.; Ruppin, E.; Benes, C. H.
10.1101/2021.06.03.447011 — cancer biology — Posted on 2021-06-06
3483 Federated analysis of BRCA1 and BRCA2 variation in a Japanese cohort
Casaletto, J.; Parsons, M.; Iwasaki, Y.; Momozawa, Y.; Spurdle, A. B.; Cline, M.
10.1101/2021.06.04.447169 — bioinformatics — Posted on 2021-06-06
3486 Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway
Kweon, H. Y.; Lee, M.; Dorfel, M.; Seo, S.; Gottlieb, L.; PaPazyan, T.; McTiernan, N.; Ree, R.; Bolton, D.; Garcia, A.; Flory, M.; Crain, J.; Sebold, A.; Lyons, S.; Ismail, A.; Marchi, E.; Sonn, S.-k.; Jeong, S.-J.; Jeon, S.; Ju, S.; Conway, S. J.; Kim, T.; Kim, H.-S.; Lee, C.; Roh, T.-Y.; Arnesen, T.; Marmorstein, R.; Oh, G.; Lyon, G. J.
10.1101/2020.12.19.422860 — developmental biology — Posted on 2021-06-05
3487 Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein aggregates within processing bodies
Fenix, A. M.; Miyaoka, Y.; Bertero, A.; Blue, S.; Spindler, M. J.; Tan, K. K. B.; Perez-Bermejo, J. A.; Chan, A. H.; Mayer, S. J.; Nguyen, T.; Russell, C. R.; Lizarraga, P.; Truong, A.; So, P.-L.; Kulkarni, A.; Chetal, K.; Sathe, S.; Sniadecki, N. J.; Yeo, G. W.; Murry, C. E.; Salomonis, N.
10.1101/2021.06.02.446820 — cell biology — Posted on 2021-06-05
3492 A novel, ataxic mouse model of Ataxia Telangiectasia caused by a clinically relevant nonsense mutation
Perez, H.; Abdallah, M. F.; Chavira, J. I.; Egeland, M. T.; Vo, K. L.; Sanghez, V.; Buechsenschuetz, C. L.; Kim, J. L.; Pind, M.; Nakamura, K.; Hicks, G. G.; Gatti, R. A.; Madrenas, J.; Iacovino, M.; McKinnon, P.; Mathews, P. J.
10.1101/2020.11.23.394098 — neuroscience — Posted on 2021-06-05
3493 Desiccation-driven senescence and its repression in Xerophyta schlechteri are regulated at extremely low water contents
Radermacher, A. L.; Williams, B.; Iranzadeh, A.; Dace, H.; Mundree, S.; Hilhorst, H. W.; Farrant, J. M.
10.1101/2021.06.04.447054 — plant biology — Posted on 2021-06-05
3498 Insect-specific viruses regulate vector competence in Aedes aegypti mosquitoes via expression of histone H4
Olmo, R. P.; Todjro, Y. M. H.; Aguiar, E. R. G. R.; de Almeida, J. P. P.; Armache, J. N.; de Faria, I. J. S.; Ferreira, F. V.; Silva, A. T. S.; de Souza, K. P. R.; Vilela, A. P. P.; Tan, C. H.; Diallo, M.; Gaye, A.; Paupy, C.; Obame-Nkoghe, J.; Visser, T. M.; Koenraadt, C. J. M.; Wongsokarijo, M. A.; Cruz, A. L. C.; Prieto, M. T.; Parra, M. C. P.; Nogueira, M. L.; Avelino-Silva, V.; Mota, R. N.; Borges, M. A. Z.; Drumond, B. P.; Kroon, E. G.; Sedda, L.; Marois, E.; Imler, J.-L.; Marques, J. T.
10.1101/2021.06.05.447047 — microbiology — Posted on 2021-06-05
3500 Arthritis Flares Mediated by Tissue Resident Memory T Cells in the Joint
Chang, M. H.; Levescot, A.; Nelson-Maney, N.; Blaustein, R. B.; Winden, K. D.; Morris, A.; Wactor, A.; Balu, S.; Grieshaber-Bouyer, R.; Wei, K.; Henderson, L. A.; Iwakura, Y.; Clark, R. A.; Rao, D. A.; Fuhlbrigge, R. C.; Nigrovic, P. A.
10.1101/2021.06.04.446927 — immunology — Posted on 2021-06-05
3502 Spatial cell type mapping of the oligodendrocyte lineage in the mouse juvenile and adult CNS with in situ sequencing
Hilscher, M. M.; Langseth, C. M.; Kukanja, P.; Yokota, C.; Floriddia, E.; Nilsson, M.; Castelo-Branco, G.
10.1101/2021.06.04.447052 — neuroscience — Posted on 2021-06-05
3503 Parallel valence processing alterations associated with compulsive behavior in SAPAP3 knockout mice and human OCD
Kajs, B. L.; van Roessel, P. J.; Davis, G. L.; Williams, L. M.; Rodriguez, C. I.; Gunaydin, L. A.
10.1101/2021.06.04.447162 — neuroscience — Posted on 2021-06-05
3504 Peptide-based inhibitors of Tau aggregation as a potential therapeutic for Alzheimer's disease and other Tauopathies
Aggidis, A.; Chatterjee, S.; Townsend, D.; Fullwood, N. J.; Ruiz Ortega, E.; Tarutani, A.; Hasegawa, M.; Lucas, H.; Mudher, A.; Allsop, D.
10.1101/2021.06.04.447069 — neuroscience — Posted on 2021-06-05
3506 Effect of differences in mechanical stress in vivo on the onset and progression of knee osteoarthritis
Arakawa, K.; Takahata, K.; Oka, Y.; Ozone, K.; Nakagaki, S.; Enomoto, S.; Murata, K.; Kanemura, N.; Kokubun, T.
10.1101/2021.06.04.447099 — pathology — Posted on 2021-06-05
3507 Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data
Yones, S.; Annett, A.; Stoll, P.; Diamanti, K.; Holmfeldt, L.; Barrenäs, F.; Meadows, J. R. S.; Komorowski, J.
10.1101/2021.06.03.446884 — bioinformatics — Posted on 2021-06-05
3509 Taxon-specific shifts in bacterial and archaeal transcription of dissolved organic matter cycling genes in a stratified fjord
pontiller, B.; Perez-Martinez, C.; Bunse, C.; Osbeck, C. M. G.; Gonzalez, J. M.; Lundin, D.; Pinhassi, J.
10.1101/2021.06.02.446852 — ecology — Posted on 2021-06-05
3511 Genomic differentiation within East Asian Helicobacter pylori
You, Y.; Thorell, K.; He, L.; Yahara, K.; Yamaoka, Y.; Cha, J.-H.; Murakami, K.; Katsura, Y.; TEAMHp, ; Kobayashi, I.; Falush, D.; Zhang, J.
10.1101/2021.06.05.447026 — microbiology — Posted on 2021-06-05
3512 Prenatal cadmium exposure alters proliferation in mouse CD4+ T cells via LncRNA Snhg7
McCall, J. L.; Varney, M. E.; Dziadowicz, S. A.; Hall, C.; Blethen, K. E.; Hu, G.; Barnett, J. B.; Martinez, I.
10.1101/2021.06.04.446938 — immunology — Posted on 2021-06-05
3513 Non-Coding Genetic Analysis Implicates Interleukin 18 Receptor Accessory Protein 3'UTR in Amyotrophic Lateral Sclerosis
Eitan, C.; Barkan, E.; Olender, T.; van Eijk, K. R.; Moisse, M.; Farhan, S. M. K.; Siany, A.; Hung, S.-T.; Yacovzada, N.; Cooper-Knock, J.; Kenna, K. P.; van der Spek, R. A. A.; Sproviero, W.; Al Khleifat, A.; Iacoangeli, A.; Shatunov, A. S.; Jones, A. R.; Chapnik, E.; Rothschild, D.; Weissbrod, O.; Werneburg, S.; Schafer, D. P.; Brown, R. H.; Shaw, P. J.; Van Damme, P.; van den Berg, L. H.; Phatnani, H. P.; Segal, E.; Ichida, J. K.; Al-Chalabi, A.; Veldink, J. H.; Project MinE ALS Sequencing Consortium, ; NYGC ALS Consortium, ; Hornstein, E.
10.1101/2021.06.03.446863 — neuroscience — Posted on 2021-06-05
3516 Computer-Assisted Mitotic Count Using a Deep Learning-based Algorithm Improves Inter-Observer Reproducibility and Accuracy in canine cutaneous mast cell tumors
Bertram, C. A.; Aubreville, M.; Donovan, T. A.; Bartel, A.; Wilm, F.; Marzahl, C.; Assenmacher, C.-A.; Becker, K.; Bennett, M.; Corner, S.; Cossic, B.; Denk, D.; Dettwiler, M.; Gonzalez, B. G.; Gurtner, C.; Haverkamp, A.-K.; Heier, A.; Lehmbecker, A.; Merz, S.; Noland, E. L.; Plog, S.; Schmidt, A.; Sebastian, F.; Sledge, D. G.; Smedley, R. C.; Tecilla, M.; Thaiwong, T.; Fuchs-Baumgartinger, A.; Meuten, D. J.; Breininger, K.; Kiupel, M.; Maier, A.; Klopfleisch, R.
10.1101/2021.06.04.446287 — pathology — Posted on 2021-06-05
3517 Toll-like receptor 2 orchestrates a potent anti-tumor response in non-small cell lung cancer
Millar, F. R.; Pennycuick, A.; Muir, M.; Quintanilla, A.; Hari, P.; Freyer, E.; Gautier, P.; Meynert, A.; Teixeira, V. H.; Connelly, J.; Wallace, W. A.; Sims, A. H.; Frame, M. C.; Boulter, L.; Janes, S. M.; Wilkinson, S.; Acosta, J. C.
10.1101/2021.06.04.446876 — cancer biology — Posted on 2021-06-05
3518 STED super-resolution imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes
Carravilla, P.; Dasgupta, A.; Zhurgenbayeva, G.; Danylchuk, D. I.; Klymchenko, A. S.; Sezgin, E.; Eggeling, C.
10.1101/2021.06.05.446432 — biophysics — Posted on 2021-06-05
3526 Adjuvant and immunomodulatory potential of Natural Killer T (NKT) activation by NKTT320
Bond, N. G.; Fahlberg, M. D.; Yu, S.; Rout, N.; Tran, D.; Fitzpatrick-Schmidt, T.; Sprehe, L. M.; Scheef, E. A.; Mudd, J. C.; Schaub, R. G.; Kaur, A.
10.1101/2021.04.27.441000 — immunology — Posted on 2021-06-05
3531 The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host-switching
Mourier, T.; de Alvarenga, D. A. M.; Kaushik, A.; de Pina-Costa, A.; Guzman-Vega, F. J.; Douvropoulou, O.; Guan, Q.; Forrester, S.; de Abreu, F. V. S.; Junior, C. B.; Junior, J. C. d. S.; Hirano, Z. M. B.; Pissinatti, A.; Moreira, S. B.; Ferreira-da-Cruz, M. d. F.; de Oliveira, R. L.; Arold, S. T.; Jeffares, D. C.; Brasil, P.; de Brito, C. F. A.; Culleton, R.; Daniel-Ribeiro, C. T.; Pain, A.
10.1101/841171 — genomics — Posted on 2021-06-05
3533 Long-reads are revolutionizing 20 years of insect genome sequencing
Hotaling, S.; Sproul, J. S.; Heckenhauer, J.; Powell, A.; Larracuente, A. L.; Pauls, S. U.; Kelley, J. L.; Frandsen, P. B.
10.1101/2021.02.14.431146 — genomics — Posted on 2021-06-05
3535 Genetic expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy
Nguyen, L. H.; Xu, Y.; Mahadeo, T.; Zhang, L.; Lin, T. V.; Born, H. A.; Anderson, A. E.; Bordey, A.
10.1101/2021.06.04.445850 — neuroscience — Posted on 2021-06-05
3536 African swine fever virus structural protein p17 inhibits cGAS-STING signaling pathway through interacting with STING
Zheng, W.; Xia, N.; Luo, J.; Jiang, S.; Zhang, J.; Wang, H.; Ao, D.; Xu, Y.; Liu, X.; Shao, Q.; Cao, Q.; Zhang, Y.; Chen, N.; Zhang, Q.; Da, J.; Chen, H.; Guo, X.; Zhu, H.; Meurens, F.; Zhu, J.
10.1101/2021.06.02.446854 — immunology — Posted on 2021-06-05
3537 Comparative phylogenomic analysis reveals evolutionary genomic changes and novel toxin families in endophytic Liberibacter pathogens
Zhang, D.; Tan, Y.; Wang, C.; Schneider, T.; Li, H.; de Souza, R. F.; Tang, X.; Hsieh, T.-F.; Wang, X.; Li, X.
10.1101/2021.06.02.446850 — microbiology — Posted on 2021-06-05
3538 An Alanine Aminotransferase is Required for Polysaccharide Regulation and Resistance of Aspergillus fumigatus Biofilms to Echinocandin Treatment
Kerkaert, J. D.; Le Mauff, F.; Wucher, B. R.; Beattie, S. R.; Vesely, E. M.; Sheppard, D.; Nadell, C. D.; A. Cramer, R.
10.1101/2021.06.03.446912 — microbiology — Posted on 2021-06-05
3539 Fungal extracellular vesicles are involved in intraspecies intracellular communication
Bittencourt, T. A.; Hatanaka, O.; Pessoni, A. M.; Freitas, M. S.; Trentin, G.; Santos, P.; Rossi, A.; Martinez-Rossi, N. M.; Alves, L. R.; Casadevall, A.; Rodrigues, M.; Almeida, F.
10.1101/2021.06.03.447024 — microbiology — Posted on 2021-06-05
3540 The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε
Luo, J.; Ni, J.; Jiang, S.; Xia, N.; Guo, Y.; Shao, Q.; Zhang, J.; Cao, Q.; Xu, Z.; Zheng, W.; Chen, N.; Zhang, Q.; Chen, H.; Guo, X.; Zhu, H.; Meurens, F.; Zhu, J.
10.1101/2021.06.02.446855 — immunology — Posted on 2021-06-05
3543 Composite solid lipid nanoparticles with hydrogel core for delivering small hydrophilic molecules to the retina: an in vitro study using ARPE-19 and 661W cells
Himawan, E.; Huang, L.; Belhadj, S.; Perez Garcia, R. O.; Paquet-Durand, F.; Schipper, N.; Buzgo, M.; Marigo, V.; Simaite, A.
10.1101/2021.05.24.445543 — neuroscience — Posted on 2021-06-05
3544 Dimerization mechanism and structural features of human LI-cadherin
Yui, A.; Caaveiro, J. M. M.; Kuroda, D.; Nakakido, M.; Nagatoishi, S.; Goda, S.; Maruno, T.; Uchiyama, S.; Tsumoto, K.
10.1101/2020.09.18.291195 — biochemistry — Posted on 2021-06-05
3551 Blinking fluorescent probes for tubulin nanoscopy in living and fixed cells
Gerasimaite, R.; Bucevicius, J.; Kiszka, K. A.; Kostiuk, G.; Koenen, T.; Lukinavicius, G.
10.1101/2021.06.01.446685 — cell biology — Posted on 2021-06-04
3552 System genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose
Kempermann, G.; Grzyb, A. N.; Overall, R. W.; Silhavy, J.; Mlejnek, P.; Malinska, H.; Hüttl, M.; Markova, I.; Fabel, K. S.; Lu, L.; Stuchlik, A.; Williams, R. W.; Pravenec, M.
10.1101/2021.06.04.447058 — neuroscience — Posted on 2021-06-04
3553 A spatiotemporal complexity architecture of human brain activity
Krohn, S.; von Schwanenflug, N.; Waschke, L.; Romanello, A.; Gell, M.; Garrett, D. D.; Finke, C.
10.1101/2021.06.04.446948 — neuroscience — Posted on 2021-06-04
3554 U-RISC: An Ultra-high Resolution EM Dataset Challenging Existing Deep Learning Algorithms
Shi, R.; Wang, W.; Li, Z.; He, L.; Sheng, K.; Ma, L.; Du, K.; Jiang, T.; Huang, T.
10.1101/2021.05.30.446334 — neuroscience — Posted on 2021-06-04
3556 Retinoic acid exerts sexually dimorphic effects over muscle energy metabolism and function
Zhao, Y.; Vuckovic, M.; Yoo, H. S.; Fox, N.; Rodriguez, A.; McKessy, K.; Napoli, J. L.
10.1101/2021.06.04.447134 — biochemistry — Posted on 2021-06-04
3557 Improved draft reference genome for the Glassy-winged Sharpshooter (Homalodisca vitripennis), a vector for Pierce's disease
Ettinger, C. L.; Byrne, F. J.; Collin, M. A.; Carter-House, D.; Walling, L. L.; Atkinson, P. W.; Redak, R. A.; Stajich, J. E.
10.1101/2021.06.04.447158 — genomics — Posted on 2021-06-04
3558 Biallelic loss-of-function OBSCN variants predispose individuals to severe, recurrent rhabdomyolysis
Cabrera-Serrano, M.; Caccavelli, L.; Savarese, M.; Vihola, A.; Jokela, M.; Johari, M.; Capiod, T.; Madrange, M.; Bugiardini, E.; Brady, S.; Quinlivan, R.; Merve, A.; Scalco, R.; Hilton-Jones, D.; Houlden, H.; Aydin, H.; Ceylaner, S.; Vockley, J.; Taylor, R.; Goullee, H.; Ylikallio, E.; Auranen, M.; Tyynismaa, H.; Udd, B.; Davis, M.; Forrest, A.; Bratkovic, D.; Manton, N.; Robertson, T.; McCombe, P.; Laing, N.; Phillips, L.; Delonlay, P.; Ravenscroft, G.
10.1101/2021.06.04.447044 — genetics — Posted on 2021-06-04
3559 C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair
Thijssen, K. L.; van der Woude, M.; Davo-Martinez, C.; Sabatella, M.; Vermeulen, W.; Lans, H.
10.1101/2021.06.04.447037 — genetics — Posted on 2021-06-04
3561 Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects
Robertson, N. A.; Latorre-Crespo, E.; Terrada-Terradas, M.; Purcell, A. C.; Livesey, B. J.; Marsh, J. A.; Murphy, L.; Fawkes, A.; MacGillvray, L.; Copland, M.; Marioni, R. E.; Harris, S. E.; Cox, S. R.; Deary, I. J.; Schumacher, L. J.; Kirschner, K.; Chandra, T.
10.1101/2021.05.27.446006 — cell biology — Posted on 2021-06-04
3563 Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome
Huiting, W.; Dekker, S. L.; van der Lienden, J.; Mergener, R.; Furtado, G. V.; Gerrits, E.; Musskopf, M. K.; Oghbaie, M.; Di Stefano, L. H.; van waarde-Verhagen, M. A.; Couzijn, S.; Barazzuol, L.; LaCava, J.; Kampinga, H. H.; Bergink, S.
10.1101/2021.06.04.447142 — molecular biology — Posted on 2021-06-04
3566 DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells
Waldrip, Z. J.; Burdine, L.; Harrison, D. K.; Azevedo-Pouly, A. C.; Storey, A. J.; Moffett, O. G.; Mackintosh, S. G.; Burdine, M. S.
10.1101/2021.06.04.446996 — molecular biology — Posted on 2021-06-04
3568 CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids
Pinilla-Redondo, R.; Russel, J.; Mayo-Munoz, D.; Shah, S. A.; Garrett, R. A.; Nesme, J.; Madsen, J. S.; Fineran, P. C.; Soerensen, S. J.
10.1101/2021.06.04.447074 — microbiology — Posted on 2021-06-04
3569 Bacteroides thetaiotaomicron uses a widespread extracellular DNase to promote bile-dependent biofilm formation
BECHON, N.; MIHAJLOVIC, J.; LOPES, A.-A.; VENDRELL-FERNANDEZ, S.; DESCHAMPS, J.; BRIANDET, R.; SISMEIRO, O.; MARTIN-VERSTRAETE, I.; DUPUY, B.; GHIGO, J.-M.
10.1101/2021.06.04.447082 — microbiology — Posted on 2021-06-04
3570 The enteric pathogen Cryptosporidium parvum exports proteins into the cytoplasm of the infected cell
Dumaine, J. E.; Sateriale, A.; Gibson, A. R.; Reddy, A. G.; Gullicksrud, J. A.; Hunter, E. N.; Clark, J. T.; Striepen, B.
10.1101/2021.06.04.447155 — microbiology — Posted on 2021-06-04
3574 Aβ initiates brain hypometabolism and network dysfunction via NOX2 activation: a potential onset mechanism of Alzheimer's disease
Malkov, A.; Popova, I.; Ivanov, A.; Jang, S.-S.; Yoon, S. Y.; Osipov, A.; Huang, Y.; Zilberter, Y.; Zilberter, M.
10.1101/2020.08.12.248492 — neuroscience — Posted on 2021-06-04
3578 Real-time environmental monitoring of contaminants using living electronic sensors
Atkinson, J. T.; Su, L.; Zhang, X.; Bennett, G. N.; Silberg, J.; Ajo-Franklin, C.
10.1101/2021.06.04.447163 — synthetic biology — Posted on 2021-06-04
3579 Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)
Jiang, H.; Muir, R. K.; Gonciarz, R. L.; Olshen, A. B.; Yeh, I.; Hann, B. C.; Zhao, N.; Wang, Y.-h.; Korkola, J.; Behr, S. C.; Evans, M. J.; collisson, e.; Renslo, A.
10.1101/2020.05.12.088971 — cancer biology — Posted on 2021-06-04
3581 Optimizing microtubule arrangements for rapid cargo capture
Mogre, S. S.; Christensen, J. R.; Reck-Peterson, S. L.; Koslover, E.
10.1101/2021.06.02.446824 — biophysics — Posted on 2021-06-04
3582 FILER: large-scale, harmonized FunctIonaL gEnomics Repository
Kuksa, P. P.; Gangadharan, P.; Katanic, Z.; Kleidermacher, L.; Amlie-Wolf, A.; Lee, C.-Y.; Qu, L.; Greenfest-Allen, E.; Valladares, O.; Leung, Y. Y.; Wang, L.-S.
10.1101/2021.01.22.427681 — bioinformatics — Posted on 2021-06-04
3583 Human single-chain antibodies neutralize SARS-CoV-2 variants by engaging an essential epitope of the spike: a new weapon against COVID-19
Minenkova, O.; Santapaola, D.; Milazzo, F. M.; Anastasi, A.; Battistuzzi, G.; Chiapparino, C.; Rosi, A.; Gritti, G.; Borleri, G.; Rambaldi, A.; Dental, C.; Viollet, C.; Pagano, B.; Salvini, L.; Marra, E.; Luberto, L.; Rossi, A.; Riccio, A.; Merlo Pich, E.; Santoro, M. G.; De Santis, R.
10.1101/2021.06.04.447066 — bioengineering — Posted on 2021-06-04
3585 Systems-wide analysis of glycoprotein conformational changes by limited deglycosylation assay
Mule, S. N.; Rosa-Fernandes, L.; Coutinho, J. V. P.; Gomes, V. D. M.; Macedo-da-Silva, J.; Santiago, V. F.; Quina, D. O.; de Oliveira, G. S.; Thaysen-Andersen, M.; Larsen, M. R.; Labriola, L.; Palmisano, G.
10.1101/2021.06.04.447131 — biochemistry — Posted on 2021-06-04
3587 Interrogation of cancer gene dependencies reveals novel paralog interactions of autosome and sexchromosome encoded genes
Köferle, A.; Schlattl, A.; Hörmann, A.; Spreitzer, F.; Popa, A. M.; Thatikonda, V.; Puchner, T.; Oberndorfer, S.; Wieshofer, C.; Corcokovic, M.; Reiser, C.; Wöhrle, S.; Popow, J.; Pearson, M.; Mair, B.; Neumüller, R. A.
10.1101/2021.05.21.445116 — genomics — Posted on 2021-06-04
3589 Maize Brittle Stalk2-Like3, encoding a COBRA protein, functions in cell wall formation and carbohydrate partitioning
Julius, B. T.; McCubbin, T. J.; Mertz, R. A.; Baert, N.; Knoblauch, J.; Grant, D. G.; Conner, K.; Bihmidine, S.; Chomet, P.; Wagner, R.; Woessner, J.; Grote, K.; Peevers, J.; Slewinski, T. L.; McCann, M. C.; Carpita, N. C.; Knoblauch, M.; Braun, D. M.
10.1101/2021.06.04.447139 — genetics — Posted on 2021-06-04
3590 Evolution of genome fragility enables microbial division of labor
Colizzi, E. S.; van Dijk, B.; Merks, R. M. H.; Rozen, D. E.; Vroomans, R. M.
10.1101/2021.06.04.447040 — evolutionary biology — Posted on 2021-06-04
3592 A hybrid in silico approach reveals novel inhibitors of multiple SARS-CoV-2 variants
Jain, S.; Talley, D. C.; Baljinnyam, B.; Choe, J.; Hanson, Q.; Zhu, W.; Xu, M.; Chen, C. Z.; Zheng, W.; Hu, X.; Shen, M.; Rai, G.; Hall, M.; Simeonov, A.; Zakharov, A. V.
10.1101/2021.06.04.447130 — cell biology — Posted on 2021-06-04
3593 AKAP350 regulates LFA-1 organization during NK cytolytic response
Pariani, A. P.; Almada, E.; Hidalgo, F.; Borini-Etichetti, C.; Vena, R.; Marin, L.; Favre, C.; Goldenring, J. R.; Larocca, M. C.
10.1101/2020.10.27.357970 — cell biology — Posted on 2021-06-04
3594 The Rab GTPase activating protein TBC-2 extends longevity by facilitating release of FOXO/DAF-16 from endosomes
Meras, I.; Chotard, L.; Liontis, T.; Ratemi, Z.; Wiles, B.; Seo, J. H.; Van Raamsdonk, J. M.; Rocheleau, C. E.
10.1101/2021.06.04.447106 — cell biology — Posted on 2021-06-04
3596 Screening of Botanical Drugs against SARS-CoV-2 Entry
Cao, J.; Liu, Y.; Zhou, M.; Dong, S.; Jia, X.; Lan, X.; Zhang, Y.; Guo, J.; Xiao, G.; Wang, W.
10.1101/2021.06.03.447021 — microbiology — Posted on 2021-06-04
3597 FINE-SCALE ADAPTATIONS TO ENVIRONMENTAL VARIATION AND GROWTH STRATEGIES DRIVE PHYLLOSPHERE METHYLOBACTERIUM DIVERSITY.
Leducq, J.-B.; Seyer-Lamontagne, E.; Condrain-Morel, D.; Bourret, G.; Sneddon, D.; Foster, J. A.; Marx, C. J.; Sullivan, J. M.; Shapiro, B. J.; Kembel, S. W.
10.1101/2021.06.04.447128 — microbiology — Posted on 2021-06-04
3603 Staphylococcus aureus-serine protease-like protein B (SplB) activates PAR2 and induces endothelial barrier dysfunction
Chandrabalan, A.; Thibeault, P. E.; Smiljanov, B.; Mittmann, L. A.; Deinhardt-Emmer, S.; Nordengrün, M.; Iqbal, J.; Mrochen, D. M.; Chamling, B.; Rauch, B. H.; Reichel, C. A.; Ramachandran, R.; Bröker, B. M.; Darisipudi, M. N.
10.1101/2020.12.30.424670 — immunology — Posted on 2021-06-04
3604 Mapping Brain-Behavior Space Relationships Along the Psychosis Spectrum
Ji, J. L.; Helmer, M.; Fonteneau, C.; Burt, J. B.; Tamayo, Z.; Demsar, J.; Adkinson, B.; Savic, A.; Preller, K.; Moujaes, F.; Vollenweider, F. X.; Martin, W.; Repovs, G.; Murray, J. D.; Anticevic, A.
10.1101/2020.09.15.267310 — neuroscience — Posted on 2021-06-04
3605 Joint degeneration in a mouse model of pseudoachondroplasia: ER stress, inflammation and autophagy blockage
Hecht, J. T.; Veerisetty, A. C.; Hossain, M. G.; Patra, D.; Chiu, F.; Coustry, F.; Posey, K. L.
10.1101/2021.06.04.447121 — pathology — Posted on 2021-06-04
3607 Protein N-glycosylation is essential for SARS-CoV-2 infection
Casas-Sanchez, A.; Romero-Ramirez, A.; Hargreaves, E.; Ellis, C. C.; Grajeda, B. I.; Estevao, I.; Patterson, E. I.; Hughes, G. L.; Almeida, I. C.; Zech, T.; Acosta-Serrano, A.
10.1101/2021.02.05.429940 — microbiology — Posted on 2021-06-04
3608 JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis
Son, J.; Huang, S.; Zeng, Q.; Bricker, T. L.; Case, J. B.; Zhou, J.; Zang, R.; Liu, Z.; Chang, X.; Harastani, H. H.; Chen, L.; Gomez Castro, M. F.; Zhao, Y.; Kohio, H. P.; Hou, G.; Fan, B.; Niu, B.; Guo, R.; Rothlauf, P. W.; Bailey, A. L.; Wang, X.; Shi, P.-Y.; Martinez, E. D.; Whelan, S. P. J.; Diamond, M. S.; Boon, A. C. M.; Li, B.; Ding, S.
10.1101/2020.09.24.312165 — microbiology — Posted on 2021-06-04
3609 Genome-scale CRISPR Screens Identify Host Factors that Promote Human Coronavirus Infection
Grodzki, M.; Bluhm, A. P.; Schafer, M.; Tagmount, A.; Russo, M.; Sobh, A.; Rafiee, R.; Vulpe, C. D.; Karst, S. M.; Norris, M. H.
10.1101/2021.06.04.447090 — microbiology — Posted on 2021-06-04
3612 Visualization of SARS-CoV-2 infection dynamic
Ye, C.; Chiem, K.; Park, J.-G.; Silvas, J.; Morales Vasquez, D.; Torrelles, J. B.; Kobie, J.; Walter, M. R.; de la Torre, J. C.; Martinez-Sobrido, L.
10.1101/2021.06.03.446942 — microbiology — Posted on 2021-06-04
3613 Immunological profiling of COVID-19 patients with pulmonary sequelae
Wu, J.; Tang, L.; Ma, Y.; Li, Y.; Zhang, D.-M.; Li, Q.; Mei, H.; Hu, Y.
10.1101/2021.06.03.447023 — immunology — Posted on 2021-06-04
3615 TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons
Um, K. B.; Hahn, S.; Kim, S. W.; Lee, Y. J.; Birnbaumer, L.; Kim, H. J.; Park, M. K.
10.1101/2021.06.03.447013 — neuroscience — Posted on 2021-06-04
3616 Tumor-targeted delivery of childhood vaccine recall antigens by attenuated Listeria reduces pancreatic cancer
Selvanesan, B. C.; Chandra, D.; Quispe-Tintaya, W.; Jahangir, A.; Patel, A.; Meena, K.; Alberto Alves Da Silva, R.; Friedman, M.; Li, J.; Siddiqui, S.; Libutti, S. K.; Yuan, Z.; Beck, A.; Tesfa, L.; Koba, W.; Chuy, J.; McAuliffe, J. C.; Jafari, R.; Entenberg, D.; Wang, Y.; Condeelis, J.; DeMarais, V.; Balachandran, V.; Zhang, X.; Gravekamp, C.
10.1101/600106 — immunology — Posted on 2021-06-04
3618 Tricalbin proteins regulate plasma membrane phospholipid homeostasis
Thomas, F. B.; Omnus, D. J.; Bader, J. M.; Chung, G. H.; Kono, N.; Stefan, C. J.
10.1101/2021.06.04.447076 — cell biology — Posted on 2021-06-04
3620 Macromolecular crowding limits growth under pressure
Alric, B.; Formosa-Dague, C.; Dague, E.; Holt, L. J.; Delarue, M.
10.1101/2021.06.04.446859 — biophysics — Posted on 2021-06-04
3623 Evolution of genome fragility enables microbial division of labor
Colizzi, E. S.; Vroomans, R. M.; Rozen, D. E.; Merks, R. M. H.; van Dijk, B.
10.1101/2021.06.04.447040 — evolutionary biology — Posted on 2021-06-04
3624 The genetic diversity of honeybee colonies predicts the gut bacterial diversity of individual colony members
Bridson, C.; Vellaniparambil, L. R.; Antwis, R. E.; Müller, W.; Gilman, R. T.; Rowntree, J. K.
10.1101/2021.06.04.447042 — ecology — Posted on 2021-06-04
3627 Viral ADP-ribosyltransferases attach RNA chains to host proteins
Höfer, K.; Schauerte, M.; Grawenhoff, J.; Wulf, A.; Welp, L. M.; Billau, F. A.; Urlaub, H.; Jäschke, A.
10.1101/2021.06.04.446905 — microbiology — Posted on 2021-06-04
3628 Efficacy of heat-killed and formalin-killed vaccines against Tilapia tilapinevirus in juvenile Nile tilapia (Oreochromis niloticus)
Mai, T. T.; Kayansamruaj, P.; Taengphu, S.; Senapin, S.; Costa, J. Z.; Pozo, J. d.; Thompson, K. D.; Rodkhum, C.; Dong, H. T.
10.1101/2021.06.03.447010 — immunology — Posted on 2021-06-04
3631 Radiation-induced reprogramming drives glioma vascular transdifferentiation and tumor recurrence
Muthukrishnan, S. D.; Kawaguchi, R.; Nair, P.; Prasad, R.; Qin, Y.; Johnson, M.; Vanderveer-Harris, N.; Condro, M. C.; Alvarado, A. G.; Gau, R.; Wang, Q.; Castro, M. G.; Lowenstein, P. R.; Deb, A.; Hinman, J. D.; Pajonk, F.; Burns, T. C.; Goldman, S. R.; Geschwind, D.; Kornblum, H. I.
10.1101/2021.06.03.447005 — cancer biology — Posted on 2021-06-04
3632 SmMIP-tools: a computational toolset for processing and analysis of single-molecule molecular inversion probes derived data
Medeiros, J. J. F.; Capo-Chichi, J.-M.; Shlush, L. I.; Dick, J. E.; Arruda, A.; Minden, M. D.; Abelson, S.
10.1101/2021.06.03.446993 — genomics — Posted on 2021-06-04
3633 Adult fibroblasts retain organ-specific transcriptomic identity
Forte, E.; Ramialison, M.; Nim, H. T.; Mara, M.; Cohn, R.; Daigle, S. L.; Boyd, S.; Hinson, J. T.; Costa, M. W.; Rosenthal, N. A.; Furtado, M. B.
10.1101/2021.06.03.446915 — cell biology — Posted on 2021-06-04
3637 Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling
Whyte-Fagundes, P.; Taskina, D.; Safarian, N.; Zoidl, C.; Carlen, P. L.; Donaldson, L. W.; Zoidl, G. R.
10.1101/2021.06.03.446992 — neuroscience — Posted on 2021-06-04
3638 SALARECON connects the Atlantic salmon genome to growth and feed efficiency
Zakhartsev, M.; Rotnes, F.; Gulla, M.; Oyas, O.; van Dam, J. C. J.; Suarez-Diez, M.; Grammes, F.; Hafthorsson, R. A.; van Helvoirt, W.; Koehorst, J. J.; Schaap, P. J.; Jin, Y.; Mydland, L. T.; Gjuvsland, A. B.; Sandve, S. R.; Martins dos Santos, V. A. .P.; Vik, J. O.
10.1101/2021.06.03.446971 — systems biology — Posted on 2021-06-04
3639 Suberin plasticity to developmental and exogenous cues is regulated by a set of MYB transcription factors
Shukla, V.; Han, J.-P.; Cléard, F.; Lefebvre-Legendre, L.; Gully, K.; Flis, P.; Berhin, A.; Andersen, T. G.; Salt, D. E.; Nawrath, C.; Barberon, M.
10.1101/2021.01.27.428267 — plant biology — Posted on 2021-06-04
3640 The impact of mutational processes on structural genomic plasticity in cancer cells
Funnell, T.; O'Flanagan, C. H.; Williams, M. J.; McPherson, A.; McKinney, S.; Kabeer, F.; Lee, H.; Masud, T.; Eirew, P.; Yap, D.; Zhang, A. W.; Lim, J. L. P.; Wang, B.; Brimhall, J.; Biele, J.; Ting, J.; Liu, Y. F.; Beatty, S.; Lai, D.; Pham, J.; Grewal, D.; Abrams, D.; Havasov, E.; Leung, S.; Bojilova, V.; Moore, R. A.; Rusk, N.; Uhlitz, F.; Ceglia, N.; Weiner, A. C.; Douglas, J. M.; Zamarin, D.; Weigelt, B.; Kim, S. H.; Da Cruz Paula, A.; Reis-Filho, J. S.; Li, Y.; Xu, H.; Ruiz de Algara, T.; Lee, S. R.; Cerda Llanos, V.; IMAXT consortium, ; Shah, S. P.; Aparicio, S.
10.1101/2021.06.03.446999 — cancer biology — Posted on 2021-06-04
3643 Phenotyping of Klf14 mouse white adipose tissue enabled by whole slide segmentation with deep neural networks
Casero, R.; Westerberg, H.; Horner, N. R.; Yon, M.; Aberdeen, A.; Grau, V.; Cox, R. D.; Rittscher, J.; Mallon, A.-M.
10.1101/2021.06.03.444997 — bioinformatics — Posted on 2021-06-04
3645 Spinal neurons innervating multiple local and distant motor pools
Ronzano, R.; Lancelin, C.; Bhumbra, G. S.; Brownstone, R. M.; Beato, M.
10.1101/2021.06.03.446906 — neuroscience — Posted on 2021-06-04
3646 Robust effects of corticothalamic feedback during naturalistic visual stimulation
Spacek, M. A.; Born, G.; Crombie, D.; Bauer, Y.; Liu, X.; Katzner, S.; Busse, L.
10.1101/776237 — neuroscience — Posted on 2021-06-04
3647 Astrovirus in Reunion Free-tailed Bat (Mormopterus francoismoutoui)
Joffrin, L.; Hoarau, A. O. G.; Lagadec, E.; Koster, M.; Ramanantsalama, R. V.; Mavingui, P.; Lebarbenchon, C.
10.1101/774224 — ecology — Posted on 2021-06-04
3656 The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins
Petkau, G.; Mitchell, T. J.; Chakraborty, K.; Bell, S. E.; DAngeli, V.; Matheson, L.; Turner, D. J.; Gizlenci, O.; Salerno, F.; Katsikis, P. D.; Turner, M.
10.1101/2021.06.03.446738 — immunology — Posted on 2021-06-04
3662 GlyConnect: a glycan-based conjugation extension of the GlycoDelete technology
Van Breedam, W.; Thooft, K.; Santens, F.; Vanmarcke, S.; Wyseure, E.; Laukens, B.; Van Moer, B.; Nerinckx, W.; Devos, S.; Madder, A.; Callewaert, N.
10.1101/2021.06.02.446789 — bioengineering — Posted on 2021-06-04
3663 Movement patterns and activity levels are shaped by the neonatal environment in Antarctic fur seal pups
Nagel, R.; Mews, S.; Adam, T.; Stainfield, C.; Fox-Clarke, C.; Toscani, C.; Langrock, R.; Forcada, J.; Hoffman, J. I.
10.1101/2021.03.09.434640 — animal behavior and cognition — Posted on 2021-06-04
3665 Spatial transcriptomics reveals unique molecular fingerprints of human nociceptors
Tavares-Ferreira, D.; Shiers, S.; Ray, P.; Wangzhou, A.; Jeevakumar, V.; Sankaranarayanan, I.; Cervantes, A.; Reese, J. C.; Chamessian, A.; Copits, B.; Dougherty, P. M.; Gereau, R.; Burton, M. D.; Dussor, G.; Price, T. J.
10.1101/2021.02.06.430065 — neuroscience — Posted on 2021-06-03
3666 Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: the Multi-Targeting Drug DREAM Challenge
Xiong, Z.; Jeon, M.; Allaway, R. J.; Kang, J.; Park, D.; Lee, J.; Jeon, H.; Ko, M.; Jiang, H.; Zheng, M.; Tan, A. C.; Guo, X.; The Multi-Targeting Drug DREAM Challenge Community, ; Dang, K. K.; Tropsha, A.; Hecht, C.; Das, T. K.; Carlson, H. A.; Abagyan, R.; Guinney, J.; Schlessinger, A.; Cagan, R.
10.1101/2021.02.15.430538 — pharmacology and toxicology — Posted on 2021-06-03
3671 Hypertrophic Chondrocytes Serve as a Reservoir for Unique Marrow Associated Skeletal Stem and Progenitor Cells, Osteoblasts, and Adipocytes During Skeletal Development
Long, J. T.; Leinroth, A.; Liao, Y.; Ren, Y.; Mirando, A. J.; Nguyen, T.; Guo, W.; Sharma, D.; Wu, C.; Cheah, K.; Karner, C. M.; Hilton, M. J.
10.1101/2021.05.18.444731 — developmental biology — Posted on 2021-06-03
3674 Preserved sensory processing but hampered conflict detection when stimulus input is task-irrelevant
Nuiten, S. A.; Canales-Johnson, A.; Beerendonk, L.; Nanuashvili, N.; Fahrenfort, J. J.; Bekinschtein, T.; van Gaal, S.
10.1101/2020.10.31.363192 — neuroscience — Posted on 2021-06-03
3676 Crystal Structure of a Retroviral Polyprotein:Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)
Harrison, J. J. E. K.; Tuske, S.; Das, K.; Ruiz, F. X.; Bauman, J. D.; Boyer, P.; DeStefano, J. J.; Hughes, S. H.; Arnold, E.
10.1101/2020.11.23.395087 — biophysics — Posted on 2021-06-03
3677 Tissue fixation effects on human retinal lipid analysis by MALDI imaging and LC-MS/MS technologies
Kotnala, A.; Anderson, D. M.; Patterson, N. H.; Cantrell, L. S.; Messinger, J. D.; Curcio, C. A.; Schey, K. L.
10.1101/2021.04.29.442044 — biochemistry — Posted on 2021-06-03
3680 Adaptation and correlated fitness responses over two time scales in Drosophila suzukii populations evolving in different environments
Olazcuaga, L.; Foucaud, J.; Gautier, M.; Deschamps, C.; Loiseau, A.; Lemenager, N.; Facon, B.; Ravigne, V.; Hufbauer, R. A.; Estoup, A.; Rode, N. O.
10.1101/749945 — evolutionary biology — Posted on 2021-06-03
3682 Influence of warming temperatures on coregonine embryogenesis within and among species
Stewart, T. R.; Makinen, M.; Goulon, C.; Guillard, J.; Marjomaki, T. J.; Lasne, E.; Karjalainen, J.; Stockwell, J. D.
10.1101/2021.02.13.431107 — ecology — Posted on 2021-06-03
3686 Tumor-targeted delivery of childhood vaccine recall antigens by attenuated Listeria reduces pancreatic cancer
Selvanesan, B. C.; Chandra, D.; Quispe-Tintaya, W.; Jahangir, A.; Patel, A.; Meena, K.; Alberto Alves Da Silva, R.; Friedman, M.; Li, J.; Siddiqui, S.; Libutti, S. K.; Yuan, Z.; Beck, A.; Tesfa, L.; Koba, W.; Chuy, J.; McAuliffe, J. C.; Jafari, R.; Entenberg, D.; Wang, Y.; Condeelis, J.; DeMarais, V.; Balachandran, V.; Zhang, X.; Gravekamp, C.
10.1101/600106 — immunology — Posted on 2021-06-03
3687 Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex
Fernandez-Leon, J. A.; Engelke, D. S.; Aquino-Miranda, G.; Goodson, A.; Do Monte, F. H.
10.1101/2021.05.27.445881 — neuroscience — Posted on 2021-06-03
3688 Interrogating theoretical models of neural computation with emergent property inference
Bittner, S. R.; Palmigiano, A.; Piet, A. T.; Duan, C. A.; Brody, C. D.; Miller, K. D.; Cunningham, J. P.
10.1101/837567 — neuroscience — Posted on 2021-06-03
3690 Kinesin-3 mediated delivery of presynaptic neurexin stabilizes growing dendritic spines and postsynaptic components in vivo
Oliver, D.; Ramachandran, S.; Philbrook, A.; Lambert, C. M.; Nguyen, K. C. Q.; Hall, D. H.; Francis, M.
10.1101/2021.05.11.443328 — neuroscience — Posted on 2021-06-03
3693 Tatajuba -- Exploring the distribution of homopolymer tracts
de Oliveira Martins, L.; Bloomfield, S.; Stoakes, E.; Grant, A. J.; Page, A. J.; Mather, A. E.
10.1101/2021.06.02.446710 — bioinformatics — Posted on 2021-06-03
3695 Drug Sensitivity Prediction From Cell Line-Based Pharmacogenomics Data: Guidelines for Developing Machine Learning Models
Sharifi Noghabi, H.; Jahangiri-Tazehkand, S.; Smirnov, P.; Hon, C.; Mammoliti, A.; Kadambat Nair, S.; Singh Mer, A.; Ester, M.; Haibe-Kains, B.
10.1101/2021.04.09.439076 — bioinformatics — Posted on 2021-06-03
3698 Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D
Deng, Y.; Deng, S.; Ho, Y.-H.; Gardner, S. M.; Huang, Z.; Marmorstein, R.; Huang, R.
10.1101/2021.01.24.427995 — biochemistry — Posted on 2021-06-03
3699 The Foundational data initiative for Parkinsons disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanism
Bressan, E.; Reed, X.; Bansal, V.; Hutchins, E.; Cobb, M. M.; Webb, M. G.; Alsop, E.; Grenn, F. P.; Illarionova, A.; Savytska, N.; Violich, I.; Broeer, S.; Fernandes, N.; Sivakumar, R.; Beilina, A.; Billingsley, K.; Berghausen, J.; Pantazis, C. B.; Meechoovet, B.; Reiman, R.; Courtright-Lim, A.; Logemann, A.; Antone, J.; Barch, M.; Kitchen, R.; Li, Y.; Dalgard, C. L.; The American Genome Center, ; Rizzu, P.; Hernandez, D. G.; Hjelm, B. E.; Nalls, M. A.; Gibbs, J. R.; Finkbeiner, S.; Cookson, M. R.; Van Keuren-Jensen, K.; Craig, D. W.; Singleton, A. B.; Heutink, P.; Blauwendraat, C.
10.1101/2021.06.03.446785 — genomics — Posted on 2021-06-03
3702 Ssl2/TFIIH Function in Transcription Start Site Scanning by RNA Polymerase II in Saccharomyces cerevisiae
Zhao, T.; Vvedenskaya, I. O.; Lai, W. K. M.; Basu, S.; Pugh, B. F.; Nickels, B. E.; Kaplan, C. D.
10.1101/2021.05.05.442816 — molecular biology — Posted on 2021-06-03
3703 Neuroscience Cloud Analysis As a Service
Abe, T.; Kinsella, I.; Saxena, S.; Buchanan, E. K.; Couto, J.; Briggs, J.; Kitt, S. L.; Glassman, R.; Zhou, J.; Paninski, L.; Cunningham, J. P.
10.1101/2020.06.11.146746 — neuroscience — Posted on 2021-06-03
3707 Sorting droplets into many outlets
Vyawahare, S.; Brundage, M.; Kijac, A.; Gutierrez, M.; de Geus, M.; Sinha, S.; Homyk, A.
10.1101/2021.06.03.446983 — bioengineering — Posted on 2021-06-03
3709 Nitrogen fixation in mesoscale eddies of the North Pacific Subtropical Gyre: patterns and mechanisms
Dugenne, M.; Gradoville, M. R.; Church, M. J.; Barone, B.; Wilson, S. T.; Sheyn, U.; Harke, M.; Björkman, K. M.; Hawco, N. J.; Hynes, A. M.; Ribalet, F.; White, A. E.; Karl, D. M.; DeLong, E. F.; Dyhrman, S. T.; Armbrust, E. V.; John, S.; Eppley, J. M.; Harding, K.; Stewart, B.; Cabello, A. M.; Turk-Kubo, K. A.; Caffin, M.; Zehr, J.
10.1101/2021.06.03.446955 — ecology — Posted on 2021-06-03
3712 CD4+ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent
Popescu, I.; Snyder, M. E.; Iasella, C. J.; Hannan, S. J.; Koshy, R.; Burke, R.; Das, A.; Brown, M. J.; Lyons, E. J.; Lieber, S. C.; Chen, X.; Sembrat, J. C.; An, X.; Linstrum, K.; Kitsios, G.; Konstantinidis, I.; Saul, M.; Kass, D. J.; Alder, J. K.; Chen, B. B.; Lendermon, E. A.; Kilaru, S.; Johnson, B.; Morrell, M. R.; Pilewski, J. M.; Kiss, J. E.; Wells, A. H.; Morris, A.; McVerry, B. J.; McMahon, D. K.; Triulzi, D. J.; Chen, K.; Sanchez, P. G.; McDyer, J. F.
10.1101/2021.06.02.446831 — immunology — Posted on 2021-06-03
3713 The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA supertype-dependent manner
Hamelin, D. J.; Fournelle, D.; Grenier, J.-C.; Schockaert, J.; Kovalchik, K.; Kubiniok, P.; Mostefai, F.; Duquette, J. D.; Saab, F.; Sirois, I.; Smith, M.; Pattijn, S.; Soudeyns, H.; Decaluwe, H.; Hussin, J.; Caron, E.
10.1101/2021.06.03.446959 — immunology — Posted on 2021-06-03
3715 Pathogenic neutrophilia drives acute respiratory distress syndrome in severe COVID-19 patients
Eddins, D. J.; Yang, J.; Kosters, A.; Giacalone, V.; Pechuan, X.; Chandler, J. D.; Babcock, B. R.; Eum, J.; Hernandez, M. R.; Abdulkhader, F.; Collins, G. L.; Ramonell, R. P.; Moussion, C.; Orlova, D.; Sanz, I.; Lee, F. E.-H.; Tirouvanziam, R.; Ghosn, E.
10.1101/2021.06.02.446468 — immunology — Posted on 2021-06-03
3717 Enteric coronavirus infection and treatment modeled with an immunocompetent human intestine-on-a-chip
Bein, A.; Kim, S.; Goyal, G.; Cao, W.; Fadel, C.; Naziripour, A.; Sharma, S.; Swenor, B.; LoGrande, N.; Nurani, A.; Miao, V. N.; Navia, A. W.; Ziegler, C. G.; Ordovas-Montanes, J.; Prabhala, P.; Kim, M. S.; Prantil-Baun, R.; Rodas, M.; Jiang, A.; Tillya, G.; Shalek, A. K.; Ingber, D. E.
10.1101/2021.06.03.446968 — bioengineering — Posted on 2021-06-03
3721 PHARP: A pig haplotype reference panel for genotype imputation
Wang, Z.; Zhang, Z.; Chen, Z.; Sun, J.; Cao, C.; Wu, F.; Xu, Z.; Guo, L.; Sun, H.; Zhao, W.; Zhang, Z.; Wang, Q.; Pan, Y.
10.1101/2021.06.03.446888 — genomics — Posted on 2021-06-03
3723 A large chromosomal inversion shapes gene expression in seaweed flies (Coelopa frigida)
Berdan, E.; Merot, C.; Pavia, H.; Johannesson, K.; Wellenreuther, M.; Butlin, R. K.
10.1101/2021.06.03.446913 — evolutionary biology — Posted on 2021-06-03
3726 Single cell clonal analysis identifies an AID-dependent pathway of plasma cell differentiation
Gomez-Escolar, C.; Serrano-Navarro, A.; Benguria, A.; Dopazo, A.; Sanchez-Cabo, F.; Ramiro, A. R.
10.1101/2021.06.03.446763 — immunology — Posted on 2021-06-03
3727 Lung epithelial signaling mediates early vaccine-induced CD4+ T cell activation and Mtb control
Das, S.; Marin, N. D.; Esaulova, E.; Ahmed, M.; Swain, A.; Rosa, B. A.; Mitreva, M.; Rangel-Moreno, J.; Netea, M.; Barreiro, L. B.; Divangahi, M.; Artyomov, M.; Kaushal, D.; Khader, S. A.
10.1101/2021.06.03.446981 — immunology — Posted on 2021-06-03
3728 Lack of p62 impairs glycogen aggregation and exacerbates pathology in a mouse model of myoclonic epilepsy of Lafora
Pellegrini, P.; Hervera Abad, A.; Varea, O.; brewer, M. K.; Lopez-Soldado, I.; Guitart, A.; Aguilera, M.; Prats-Costa, N.; Del Rio, J. A.; Guinovart, J. J.; Duran, J.
10.1101/2021.06.03.446965 — neuroscience — Posted on 2021-06-03
3730 Novel temporal and spatial patterns of metastatic colonization from rapid-autopsy tumor biopsies
Huang, X.; Qiao, Y.; Brady, S. W.; Factor, R. E.; Downs-Kelly, E.; Farrell, A.; McQuerry, J. A.; Shrestha, G.; Jenkins, D. F.; Johnson, W. E.; Cohen, A. L.; Bild, A. H.; Marth, G. T.
10.1101/2021.06.03.446803 — cancer biology — Posted on 2021-06-03
3731 A novel tubulin binding molecule drives differentiation of acute myeloid leukaemia cells
Jackson, T. R.; Vuorinen, A.; Josa-Cullere, L.; Madden, K. S.; Conole, D.; Cogswell, T. J.; Wilkinson, I. V. L.; Kettyle, L. M.; Zhang, D.; O'Mahony, A.; Gracias, D.; McCall, L.; Westwood, R.; Terstappen, G. C.; Davies, S. G.; Tate, E. W.; Wynne, G. M.; Vyas, P.; Russell, A.; Milne, T.
10.1101/2021.06.03.446952 — cancer biology — Posted on 2021-06-03
3739 Structural basis for sterol sensing by Scap and Insig
Yan, N.; Yan, C.; Yan, R.; Cao, P.; Song, W.; Li, Y.; Wang, T.; Qian, H.
10.1101/2021.06.03.446951 — biochemistry — Posted on 2021-06-03
3741 Genome-wide approaches delineate the additive, epistatic, and pleiotropic nature of variants controlling fatty acid composition in peanut (Arachis hypogaea L.).
Otyama, P. I.; Chamberlin, K.; Ozias-Akins, P.; Graham, M. A.; Cannon, E. K. S.; Cannon, S. B.; MacDonald, G. E.; Anglin, N. L.
10.1101/2021.06.03.446924 — genomics — Posted on 2021-06-03
3742 Identification of a motif in Trm732 required for 2'-O-methylation of the tRNA anticodon loop by Trm7
Funk, H. M.; DiVita, D. J.; Sizemore, H. E.; Wehrle, K.; Weiner, C. L.; Guy, A. R.; Phizicky, E. M.; Guy, M. P.
10.1101/2021.06.03.446962 — genetics — Posted on 2021-06-03
3743 Western Amazon was a center of Neotropical fish dispersal, as evidenced by the continental-wide time-stratified biogeographic analysis of the hyper-diverse Hypostomus catfish
Jardim de Queiroz, L.; Meyer, X.; Cardoso, Y. P.; Bahechar, I. A.; Covain, R.; Parente, T. E.; Torrente-Vilara, G.; Buckup, P. A.; Montoya-Burgos, J. I.
10.1101/2021.06.03.446980 — evolutionary biology — Posted on 2021-06-03
3745 The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins
Petkau, G.; Mitchell, T. J.; Chakraborty, K.; Bell, S. E.; DAngeli, V.; Matheson, L.; Turner, D. J.; Salerno, F.; Katsikis, P. D.; Turner, M.
10.1101/2021.06.03.446738 — immunology — Posted on 2021-06-03
3750 A representative reference for MRI-based human axon radius assessment using light microscopy
Mordhorst, L.; Morozova, M.; Papazoglou, S.; Fricke, B.; Oeschger, J. M.; Tabarin, T.; Rusch, H.; Jaeger, C.; Geyer, S.; Weiskopf, N.; Morawski, M.; Mohammadi, S.
10.1101/2021.06.03.446739 — neuroscience — Posted on 2021-06-03
3751 NLoed: A Python package for nonlinear optimal experimental design in systems biology
Braniff, N.; Pearce, T.; Lu, Z.; Astwood, M.; Forrest, W. S.; Receno, C.; Ingalls, B. P.
10.1101/2021.06.03.446189 — systems biology — Posted on 2021-06-03
3752 Large-scale characterisation of the pregnancy vaginal microbiome and sialidase activity in a low-risk Chinese population
Ng, S.; Chen, M.; Kundu, S.; Wang, X.; Zhou, Z.-Y.; Zheng, Z.; Qing, W.; Sheng, H.; Wang, Y.; He, Y.; Bennet, P.; MacIntyre, D. A.; Zhou, H.-W.
10.1101/2021.06.02.446856 — systems biology — Posted on 2021-06-03
3753 Dual control of MAPK activities by AP2C1 and MKP1 MAPK phosphatases regulates defence responses in Arabidopsis
Ayatollahi, Z.; Kazanaviciute, V.; Shubchynskyy, V.; Kvederaviciute, K.; Schwanninger, M.; Rozhon, W.; Stumpe, M.; Mauch, F.; Bartels, S.; Ulm, R.; Balazadeh, S.; Mueller-Roeber, B.; Meskiene, I.; Schweighofer, A.
10.1101/2021.06.03.446911 — plant biology — Posted on 2021-06-03
3756 AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in Castrate-Resistant Prostate Cancer
Kim, S.; Jamalruddin, M. A. B.; Au, C. C.; Mukhtar, E.; Portella, L.; Berger, A.; Worroll, D.; Rickman, D. S.; Nanus, D. M.; Giannakakou, P.
10.1101/2021.06.03.446940 — cancer biology — Posted on 2021-06-03
3760 An automated platform for structural analysis of membrane proteins through serial crystallography
Healey, R. D.; Basu, S.; Humm, A.-S.; Leyrat, C.; Cong, X.; Golebiowski, J.; Dupeux, F.; Pica, A.; Granier, S.; Marquez, J. A.
10.1101/2021.06.03.446146 — biochemistry — Posted on 2021-06-03
3761 Zebrafish Danio rerio trunk muscle structure and growth from a spatial transcriptomics perspective
Liu, G.; Ito, T.; Kijima, Y.; Yoshitake, K.; Asakawa, S.; Watabe, S.; Kinoshita, S.
10.1101/2021.06.03.446321 — genomics — Posted on 2021-06-03
3762 Cell atlas of the regenerating human liver after portal vein embolization
Brazovskaja, A.; Gomes, T.; Körner, C.; He, Z.; Schaffer, T.; Eckel, J. C.; Hänsel, R.; Santel, M.; Denecke, T.; Dannemann, M.; Brosch, M.; Hampe, J.; Seehofer, D.; Damm, G.; Camp, J. G.; Treutlein, B.
10.1101/2021.06.03.444016 — genomics — Posted on 2021-06-03
3764 Fungal gasdermin-like proteins are controlled by proteolytic cleavage
Clave, C.; Dyrka, W.; Granger-Farbos, A.; Pinson, B.; Saupe, S. J.; Daskalov, A.
10.1101/2021.06.03.446900 — genetics — Posted on 2021-06-03
3766 Sea Turtle Facial Recognition Using Map Graphs of Scales
Rao, K. K.; Grabow, L. C.; Munoz-Perez, J. P.; Alarcon-Ruales, D.; Azevedo, R. B. R.
10.1101/2021.06.03.446936 — ecology — Posted on 2021-06-03
3767 Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans
Martinez-Fernandez, C.; Bergamino, M.; Brena, D.; Ventura, N.; Honnen, S.; Villanueva, A.; Nadal, E.; Ceron, J.
10.1101/2021.06.03.445826 — cell biology — Posted on 2021-06-03
3768 M1-linked ubiquitination facilitates NF-κB activation during sterile inflammation
Aalto, A.; Martinez-Chacon, G.; Tsyganova, N.; Kreutzer, J.; Kallio, P.; Broemer, M.; Meinander, A.
10.1101/2021.06.03.446895 — cell biology — Posted on 2021-06-03
3774 Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir
Pohl, M. O.; Busnadiego, I.; Marrafino, F.; Wiedmer, L.; Hunziker, A.; Fernbach, S.; Glas, I.; Moroz-Omori, E. V.; Hale, B. G.; Caflisch, A.; Stertz, S.
10.1101/2021.03.19.435806 — microbiology — Posted on 2021-06-03
3776 A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilizing immunity against SARS-CoV-2 infection in mice
Counoupas, C.; Johnson, M. D.; Stella, A.; Nguyen, D. H.; Ferguson, A.; Aggarwal, A.; Bhattacharyya, N.; Grey, A.; Patel, K.; Siddiquee, R.; Stewart, E. L.; Hutchings, O.; Feng, C.; Hansbro, N. G. G.; Palendira, U.; Steain, M.; Saunders, B. M.; Low, J.; Mackay, J.; Kelleher, A.; Britton, W.; Turville, S.; Hansbro, P. M.; Triccas, J. A.
10.1101/2020.12.10.419044 — microbiology — Posted on 2021-06-03
3777 Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
Li, C.; Yu, D.; Wu, X.; Liang, H.; Zhou, Z.; Xie, Y.; Li, T.; Wu, J.; Lu, F.; Feng, L.; Mao, M.; Lin, L.; Guo, H.; Yue, S.; Wang, F.; Peng, Y.; Hu, Y.; Wang, Z.; Yu, J.; Zhang, Y.; Lu, J.; Ning, H.; Yang, H.; Fu, D.; He, Y.; Zhou, D.; Du, T.; Duan, K.; Dong, D.; Deng, K.; Zou, X.; Zhang, Y.; Zhou, R.; Gao, Y.; Zhang, X.; Yang, X.
10.1101/2021.04.05.437224 — immunology — Posted on 2021-06-03
3778 X-Linked Histone H3K27 Demethylase Kdm6a Regulates Sexually Dimorphic Differentiation of Hypothalamic Neurons
Cabrera Zapata, L. E.; Cisternas, C. D.; Sosa, C.; Arevalo, M. A.; Garcia-Segura, L. M.; Cambiasso, M. J.
10.1101/2021.06.03.446961 — neuroscience — Posted on 2021-06-03
3779 Identifying developing interneurons as a potential target for multiple genetic autism risk factors in human and rodent forebrain.
Yang, Y.; Booker, S. A.; Clegg, J. M.; Quintana-Urzainqui, I.; Sumera, A.; Kozic, Z. R.; Dando, O. R.; Martin Lorenzo, S.; Herault, Y.; Kind, P. C.; Price, D. J.; Pratt, T.
10.1101/2021.06.03.446920 — neuroscience — Posted on 2021-06-03
3780 Rapid Biomarker Screening of Alzheimer's Disease by Machine Learning and Graphene-Assisted Raman Spectroscopy
Wang, Z.; Ye, J.; Ding, L.; Granzier-Nakajima, T.; Sharma, S.; Biase, I.; Terrones, M.; Choi, S. H.; Ran, C.; Tanzi, R. E.; Huang, S.; Zhang, C. M.; Huang, S.
10.1101/2021.06.03.446929 — neuroscience — Posted on 2021-06-03
3781 Spinal neurons innervating multiple local and distant motor pools
Ronzano, R.; Lancelin, C.; Bhumbra, G. S.; Brownstone, R. M.; Beato, M.
10.1101/2021.06.03.446906 — neuroscience — Posted on 2021-06-03
3782 Preterm birth alters the development of cortical microstructure and morphology at term-equivalent age
Dimitrova, R.; Pietsch, M.; Ciarrusta, J.; Fitzgibbon, S. P.; Williams, L. Z.; Christiaens, D.; Cordero-Grande, L.; Batalle, D.; Makropoulos, A.; Schuh, A.; Price, A. N.; Hutter, J.; Teixeira, R. P.; Hughes, E.; Chew, A.; Falconer, S.; Carney, O.; Egloff, A.; Tournier, J.-D.; McAlonan, G.; Rutherford, M.; Counsell, S. J.; Robinson, E. C.; Hajnal, J. V.; Rueckert, D.; Edwards, D.; O'Muircheartaigh, J.
10.1101/2021.06.03.446550 — neuroscience — Posted on 2021-06-03
3785 Nuclear depletion of RNA binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis
Diaz-Garcia, S.; Ko, V. I.; Vazquez-Sanchez, S.; Chia, R.; Arogundade, O. A.; Rodriguez, M. J.; Cleveland, D. W.; Traynor, B.; Ravits, J.
10.1101/2021.06.03.446017 — neuroscience — Posted on 2021-06-03
3786 The vagus nerve is critical for regulation of hypothalamic-pituitary-adrenal axis responses to acute stress
Keller, B. N.; Snyder, A. E.; Coker, C. R.; Aguilar, E. A.; O'Brien, M. K.; Bingaman, S. S.; Arnold, A. C.; Hajnal, A.; Silberman, Y.
10.1101/2021.06.03.446790 — neuroscience — Posted on 2021-06-03
3790 Unique role and vulnerability of EP300 KIX domain in small-cell lung cancer
Kim, K.-B.; Kabra, A.; Kim, D.-W.; Xue, Y.; Hou, P.-C.; Zhou, Y.; Miranda, L.; Shi, X.; Bender, T. P.; Bushweller, J. H.; Park, K.-S.
10.1101/2021.06.03.446569 — cancer biology — Posted on 2021-06-03
3791 Philympics 2021: Prophage Predictions Perplex Programs
Roach, M. J.; McNair, K.; Giles, S. K.; Inglis, L. K.; Pargin, E.; Decewicz, P.; Edwards, R. A.
10.1101/2021.06.03.446868 — bioinformatics — Posted on 2021-06-03
3797 Ring Finger Protein 213 Assembles into a Sensor for ISGylated Proteins with Antimicrobial Activity
Thery, F.; Martina, L.; Asselman, C.; Repo, H.; Zhang, Y.; Sedeyn, K.; Moschonas, G. D.; Bredow, C.; Teo, Q. W.; Zhang, J.; Vessely, M.; Leandro, K.; Eggermont, D.; De Sutter, D.; Boucher, K.; Hochepied, T.; Festjens, N.; Callewaert, N.; Saelens, X.; Dermaut, B.; Knobeloch, K.-P.; Beling, A.; Sanyal, S.; Radoshevich, L.; Eyckerman, S.; Impens, F.
10.1101/2021.06.03.446796 — cell biology — Posted on 2021-06-03
3798 The 3D organisation of mitochondria in primate photoreceptors
Hayes, M. J.; Tracey-White, D.; Hoh Kam, J.; Powner, M. B.; Jeffery, G. J.
10.1101/2021.06.03.446914 — cell biology — Posted on 2021-06-03
3801 Single nuclei transcriptome of the Lesser Duckweed Lemna minuta reveals cell trajectories for an entire plant
Abramson, B. W.; Novotny, M.; Hartwick, N. T.; Colt, K.; Aevermann, B. D.; Scheuemann, R. H.; Michael, T. P.
10.1101/2021.06.03.446947 — genomics — Posted on 2021-06-03
3802 Divergent early antibody responses define COVID-19 disease trajectories
Chakraborty, S.; Gonzalez, J. C.; Sievers, B. L.; Mallajosyula, V.; Dubey, M.; Cheng, Y.-L. B.; Tran, K. Q. T.; Chakraborty, S.; Cassidy, A.; Chen, S. T.; Sinnott, A.; Gelbart, T.; Golan, Y.; Prahl, M.; Singh, U.; Kim-Schulze, S.; Sherwood, R.; Zhang, S.; Marron, T. U.; Gnjatic, S.; Gaw, S. L.; Nadeau, K. C.; Merad, M.; Jagannathan, P.; Tan, G. S.; Wang, T. T.
10.1101/2021.05.25.445649 — immunology — Posted on 2021-06-03
3810 Anal skin-like epithelium mediates colonic wound healing
Liu, C. Y.; Girish, N.; Gomez, M. L.; Dube, P. E.; Washington, M. K.; Simons, B. D.; Polk, D. B.
10.1101/2021.06.02.446836 — developmental biology — Posted on 2021-06-03
3811 RNA inhibits dMi-2/CHD4 chromatin binding and nucleosome remodelling
Ullah, I.; Thoelken, C.; Zhong, Y.; John, M.; Rossbach, O.; Lenz, J.; Goessringer, M.; Nist, A.; Stiewe, T.; Hartmann, R.; Vazquez, O.; Chung, H.-R.; Mackay, J.; Brehm, A.
10.1101/2021.06.03.446896 — molecular biology — Posted on 2021-06-03
3812 Drivers of Transcriptional Variance in Human Intestinal Epithelial Organoids
Criss, Z. K.; Bhasin, N.; Di Rienzi, S. C.; Rajan, A.; Deans-Fielder, K.; Swaminathan, G.; Kamyabi, N.; Zeng, X.-L.; Chakravarti, D.; Estrella, C.; Yu, X.; Patil, K.; Fleet, J. C.; Verzi, M. P.; Christakos, S.; Helmrath, M. A.; Arimura, S.; DePinho, R. A.; Britton, R.; Maresso, A.; Grande-Allen, J.; Blutt, S. E.; Crawford, S. E.; Estes, M. K.; Ramani, S.; Shroyer, N. F.
10.1101/2021.06.02.446644 — molecular biology — Posted on 2021-06-03
3814 Real-time individual benefit from social interactions before and during the lockdown: The crucial role of personality, neurobiology and genes.
Monninger, M.; Aggensteiner, P. M.; Pollok, T. M.; Reinhard, I.; Hall, A. S. M.; Zillich, L.; Streit, F.; Witt, S. H.; Reichert, M.; Ebner-Priemer, U.; Meyer-Lindenberg, A.; Tost, H.; Brandeis, D.; Banaschewski, T.; Holz, N. E.
10.1101/2021.06.02.446719 — neuroscience — Posted on 2021-06-03
3819 Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
Matas-Rico, E.; Frijlink, E.; van der Haar Avila, I.; Menegakis, A.; van Zon, M.; Morris, A. J.; Koster, J.; Salgado-Polo, F.; de Kivit, S.; Lanca, T.; Mazzocca, A.; Johnson, Z.; Haanen, J.; Schumacher, T. N.; Perrakis, A.; Verbrugge, I.; van den Berg, J.; Borst, J.; Moolenaar, W. H.
10.1101/2020.02.26.966291 — cancer biology — Posted on 2021-06-03
3820 Relative Affinities of Protein-Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations
Ansell, T. B.; Curran, L.; Horrell, M. R.; Pipatpolkai, T.; Letham, S. C.; Song, W.; Siebold, C.; Stansfeld, P. J.; Sansom, M. S. P.; Corey, R. A.
10.1101/2021.06.02.446704 — biophysics — Posted on 2021-06-03
3824 Profiling of open chromatin in developing pig (Sus scrofa) muscle to identify regulatory regions
Salavati, M.; Woolley, S. A.; Cortes Araya, Y.; Halstead, M. M.; Stenhouse, C.; Johnsson, M.; Ashworth, C. J.; Archibald, A. L.; Donadeu, F. X.; Hassan, M. A.; Clark, E. L.
10.1101/2021.01.21.426812 — genomics — Posted on 2021-06-03
3825 Utility of polygenic embryo screening for disease depends on the selection strategy
Lencz, T.; Backenroth, D.; Granot-Hershkovitz, E.; Green, A.; Gettler, K.; Cho, J.; Weissbrod, O.; Zuk, O.; Carmi, S.
10.1101/2020.11.05.370478 — genetics — Posted on 2021-06-03
3828 Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects
Robertson, N. A.; Latorre-Crespo, E.; Terrada-Terradas, M.; Purcell, A. C.; Livesey, B. J.; Marsh, J. A.; Murphy, L.; Fawkes, A.; MacGillvray, L.; Copland, M.; Marioni, R. E.; Harris, S. E.; Cox, S. R.; Deary, I. J.; Schumacher, L. J.; Kirschner, K.; Chandra, T.
10.1101/2021.05.27.446006 — cell biology — Posted on 2021-06-03
3830 DNase treatment improves viral enrichment in agricultural soil viromes
Sorensen, J. W.; Emerson, J. B.; Zinke, L. A.; ter Horst, A. M.; Santos-Medellin, C.; Schroeder, A.
10.1101/2021.06.01.446688 — microbiology — Posted on 2021-06-03
3831 The chemotherapeutic drug methotrexate selects for antibiotic resistance
Guthmundsdottir, J. S.; Fredheim, E. G. A.; Koumans, C. I. M.; Hegstad, J.; Tang, P.-C.; Andersson, D. I.; Samuelsen, O.; Johnsen, P. J.
10.1101/2020.11.12.378059 — microbiology — Posted on 2021-06-03
3832 A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling
Vasou, A.; Nightingale, K.; Cetkovska, V.; Bamford, C. G.; Andrejeva, J.; Randall, R. E.; McLauchlan, J.; Weekes, M. P.; Hughes, D. J.
10.1101/2021.06.01.446527 — immunology — Posted on 2021-06-03
3835 Mouse brain-wide mitochondrial connectivity anchored in gene, brain and behavior
Rosenberg, A.; Saggar, M.; Rogu, P.; Limoges, A. W.; Sandi, C.; Mosharov, E. V.; Dumitriu, D.; Anacker, C.; Picard, M.
10.1101/2021.06.02.446767 — neuroscience — Posted on 2021-06-03
3836 Improved spatio-temporal measurements of visually evoked fields using optically-pumped magnetometers
Gialopsou, A.; Abel, C.; James, T. M.; Coussens, T.; Bason, M. G.; Puddy, R.; Di Lorenzo, F.; Rolfs, K.; Voigt, J.; Sander, T.; Cercignani, M.; Kruger, P.
10.1101/2021.01.27.428396 — neuroscience — Posted on 2021-06-03
3837 Connectomes across development reveal principles of brain maturation
Witvliet, D.; Mulcahy, B.; Mitchell, J. K.; Meirovitch, Y.; Berger, D. R.; Wu, Y.; Liu, Y.; Koh, W. X.; Parvathala, R.; Holmyard, D.; Schalek, R. L.; Shavit, N.; Chisholm, A. D.; Lichtman, J. W.; Samuel, A. D. T.; Zhen, M.
10.1101/2020.04.30.066209 — neuroscience — Posted on 2021-06-03
3842 Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein aggregates within processing bodies
Fenix, A. M.; Miyaoka, Y.; Bertero, A.; Blue, S.; Spindler, M. J.; Tan, K. K. B.; Perez-Bermejo, J. A.; Chan, A. H.; Mayer, S. J.; Nguyen, T.; Russell, C. R.; Lizarraga, P.; Truong, A.; So, P.-L.; Kulkarni, A.; Chetal, K.; Sathe, S.; Sniadecki, N. J.; Yeo, G. W.; Murry, C. E.; Salomonis, N.
10.1101/2021.06.02.446820 — cell biology — Posted on 2021-06-03
3843 EFR3 and phosphatidylinositol 4-kinase IIIα regulate insulin-stimulated glucose transport and GLUT4 dispersal in 3T3-L1 adipocytes.
Koester, A. M.; Laidlaw, K. M.; Morris, S.; Cutiongco, M. F. A.; Stirrat, L.; Gadegaard, N.; Boles, E.; Black, H. L.; Bryant, N.; Gould, G. W.
10.1101/2021.06.02.446733 — cell biology — Posted on 2021-06-03
3845 Estrogen regulates early embryonic development of the olfactory sensory system via estrogen responsive glia
Takesono, A.; Schirrmacher, P.; Scott, A.; Green, J. M.; Lee, O.; Winter, M. J.; Kudoh, T.; Tyler, C. R.
10.1101/2021.06.03.446864 — developmental biology — Posted on 2021-06-03
3848 Differential adhesion regulates neurite placement via a retrograde zippering mechanism
Sengupta, T.; Koonce, N. L.; Moyle, M. W.; Duncan, L. H.; Vazquez-Martinez, N.; Emerson, S. E.; Han, X.; Shao, L.; Wu, Y.; Santella, A.; Fan, L.; Bao, Z.; Mohler, W. A.; Shroff, H.; Colon-Ramos, D.
10.1101/2020.08.28.271437 — neuroscience — Posted on 2021-06-03
3849 Expression Based Species Deconvolution and Realignment Removes Misalignent Error in Multi-species Single Cell Data
Choi, J.; Lee, W.; Yoon, J.-k.; Choi, S. M.; Lee, C.-H.; Moon, H.-G.; Cho, S.; Chung, J.-H.; Yang, H.-K.; Kim, J.-i.
10.1101/2021.04.04.438147 — bioinformatics — Posted on 2021-06-03
3851 The VIL gene CRAWLING ELEPHANT controls maturation and differentiation in tomato via polycomb silencing
Shwartz, I.; Yahav, C.; Kovetz, N.; Israeli, A.; Bar, M.; Levy, M.; Duval, K. L.; Jimenez-Gomez, J. M.; Deal, R. B.; Ori, N.
10.1101/2021.06.02.446760 — plant biology — Posted on 2021-06-02
3855 Klf5 establishes bi-potential cell fate by dual regulation of ICM and TE specification genes
Kinisu, M.; Choi, Y. J.; Cattoglio, C.; Liu, K.; Roux de Bezieux, H.; Valbuena, R.; Pum, N.; Dudoit, S.; Huang, H.; Xuan, Z.; Kim, S. Y.; He, L.
10.1101/2021.06.02.446799 — developmental biology — Posted on 2021-06-02
3857 Kinesin-binding protein remodels the kinesin motor to prevent microtubule-binding
Solon, A. L.; Tan, Z.; Schutt, K. L.; Jepsen, L.; Haynes, S. E.; Nesvizhskii, A. I.; Sept, D.; Stumpff, J.; Ohi, R.; Cianfrocco, M. A.
10.1101/2021.06.02.446814 — cell biology — Posted on 2021-06-02
3858 Extremely bright, near-IR emitting spontaneously blinking fluorophores enable ratiometric multicolor nanoscopy in live cells
Tyson, J.; Hu, K.; Zheng, S.; Kidd, P.; Dadina, N.; Chu, L.; Toomre, D.; Bewersdorf, J.; Schepartz, A.
10.1101/2021.06.02.446776 — cell biology — Posted on 2021-06-02
3859 The Food Additive Xanthan Gum Drives Adaptation of the Human Gut Microbiota
Ostrowski, M. P.; Leanti La Rosa, S.; Kunath, B. J.; Robertson, A.; Pereira, G.; Hagen, L. H.; Varghese, N. J.; Qiu, L.; Yao, T.; Flint, G.; Li, J.; McDonald, S.; Buttner, D.; Pudlo, N. A.; Schnizlein, M. K.; Young, V. B.; Brumer, H.; Schmidt, T.; Terrapon, N.; Lombard, V.; Henrissat, B.; Hamaker, B.; Eloe-Fadrosh, E. A.; Tripathi, A.; Pope, P. B.; Martens, E.
10.1101/2021.06.02.446819 — microbiology — Posted on 2021-06-02
3862 A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium
Van Winkle, J. A.; Peterson, S. T.; Kennedy, E. A.; Wheadon, M. J.; Ingle, H.; Desai, C.; Constant, D. A.; Wright, A. P.; Li, L.; Artyomov, M.; Lee, S.; Baldridge, M. T.; Nice, T. J.
10.1101/2021.06.02.446828 — immunology — Posted on 2021-06-02
3863 Full-length isoform transcriptome of developing human brain provides new insights into autism
Chau, K.; Zhang, P.; Urresti, J.; Amar, M.; Pramod, A. B.; Chen, J.; Thomas, A.; Corominas, R.; Lin, G. N.; Iakoucheva, L. M.
10.1101/2020.06.27.175489 — neuroscience — Posted on 2021-06-02
3865 Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids
Kim, H. S.; Xiao, Y.; Chen, X.; He, S.; Im, J.; Willner, M. J.; Finlayson, M. O.; Xu, C.; Zhu, H.; Choi, S. J.; Mosharov, E. V.; Kim, H.-W.; Xu, B.; Leong, K. W.
10.1101/2021.06.02.446827 — neuroscience — Posted on 2021-06-02
3868 Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Shao, L.-X.; Liao, C.; Gregg, I.; Davoudian, P. A.; Savalia, N.; Delagarza, K.; Kwan, A. C.
10.1101/2021.02.17.431629 — neuroscience — Posted on 2021-06-02
3869 Hippocampal replay of experience at real-world speeds
Denovellis, E. L.; Gillespie, A. K.; Coulter, M. E.; Sosa, M.; Chung, J. E.; Eden, U. T.; Frank, L. M.
10.1101/2020.10.20.347708 — neuroscience — Posted on 2021-06-02
3875 Optimizing microtubule arrangements for rapid cargo capture
Mogre, S. S.; Christensen, J. R.; Reck-Peterson, S. L.; Koslover, E.
10.1101/2021.06.02.446824 — biophysics — Posted on 2021-06-02
3878 A Fully Implantable Wireless Bidirectional Neuromodulation System for Mice
Wright, J.; Wong, J.; Mathew, J.; Mughrabi, I.; Jayaprakash, N.; Zanos, T.; Al Abed, Y.; Zanos, S.; Datta-Chaudhuri, T.
10.1101/2021.06.02.446797 — bioengineering — Posted on 2021-06-02
3880 Characterization of the consensus mucosal microbiome of colorectal cancer
Zhao, L.; Grimes, S. M.; Greer, S. U.; Kubit, M.; Lee, H.; Nadauld, L. D.; Ji, H. P.
10.1101/2021.06.02.446807 — genomics — Posted on 2021-06-02
3883 SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta
Argueta, L. B.; Lacko, L. A.; Bram, Y.; Tada, T.; Carrau, L.; Zhang, T.; Uhl, S.; Lubor, B. C.; Chandar, V.; Gil, C.; Zhang, W.; Dodson, B.; Bastiaans, J.; Prabhu, M.; Salvatore, C. M.; Yang, Y. J.; Baergen, R. N.; tenOever, B. R.; Landau, N. R.; Chen, S.; Schwartz, R. E.; Stuhlmann, H.
10.1101/2021.06.01.446676 — cell biology — Posted on 2021-06-02
3884 Direct regulation of cell cycle regulatory gene expression by NtrX to promote Sinorhizobium meliloti cell division
Xing, S.; An, F.; Yang, X.; Huang, L.; Zeng, S.; Li, N.; Zhang, L.; Zheng, W.; Ouenzar, K.; Yan, J.; Yu, L.; Luo, L.
10.1101/2020.11.06.341933 — molecular biology — Posted on 2021-06-02
3886 SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator
Hysenaj, L.; Little, S.; Kulhanek, K. R.; Gbenedio, O.; Rodriguez, L.; Shen, A.; Lone, J.-C.; Lupin-Jimenez, L. C.; Bonser, L.; Serwas, N. K.; Bahl, K.; Mick, E.; Li, J. Z.; Ding, V.; Matsumoto, S.; Maishan, M. l.; Fragiadakis, G.; Jablons, D. M.; Langelier, C. R.; Matthay, M.; Ott, M.; Sil, A.; Krummel, M.; Combes, A. J.; Erle, D. M.; Kratz, J. R.; Roose, J. P.
10.1101/2021.06.01.446640 — microbiology — Posted on 2021-06-02
3887 Characterization of the interaction domains between the phosphoprotein and the nucleocapsid of human Metapneumovirus
Decool, H.; Bardiaux, B.; Ruano, L. C.; Sperandio, O.; Fix, J.; Gutsche, I.; Richard, C.-A.; Bajorek, M.; Eleouet, J.-F.; Galloux, M.
10.1101/2021.06.02.446795 — microbiology — Posted on 2021-06-02
3890 Efficient discovery of potently neutralizing SARS-CoV-2 antibodies using LIBRA-seq with ligand blocking
Shiakolas, A. R.; Johnson, N.; Kramer, K. J.; Suryadevara, N.; Wrapp, D.; Periasamy, S.; Pilewski, K. A.; Raju, N.; Nargi, R.; Sutton, R. E.; Walker, L.; Crowe, J. E.; Bukreyev, A.; Carnahan, R. H.; McLellan, J. S.; Georgiev, I. S.
10.1101/2021.06.02.446813 — immunology — Posted on 2021-06-02
3894 Automated ChIPmentation procedure on limited biological material of the human blood fluke Schistosoma mansoni
Lasica, C.; de Carvalho Augusto, R.; Mone, H.; Mouahid, G.; Chaparro, C.; Veillard, A.-C.; Zelisko-Schmidt, A.; Grunau, C.
10.1101/2021.06.02.446743 — molecular biology — Posted on 2021-06-02
3896 Inactivation of EMILIN-1 by proteolysis and secretion in small extracellular vesicles favors melanoma progression and metastasis.
Amor Lopez, A.; Mazariegos, M. S.; Capuano, A.; Ximenez Embun, P.; Hergueta-Redondo, M.; Angel Recio, J.; Munoz, E.; Al Shahrour, F.; Munoz, J.; Megias, D.; Doliana, R.; Spessotto, P.; Peinado, H.
10.1101/2021.06.02.446715 — cancer biology — Posted on 2021-06-02
3897 GlyConnect: a glycan-based conjugation extension of the GlycoDelete technology
Van Breedam, W.; Thooft, K.; Santens, F.; Vanmarcke, S.; Wyseure, E.; Laukens, B.; Van Moer, B.; Nerinckx, W.; Devos, S.; Madder, A.; Callewaert, N.
10.1101/2021.06.02.446789 — bioengineering — Posted on 2021-06-02
3898 Targeted degradation of the oncogenic phosphatase SHP2
Vemulapalli, V.; Donovan, K. A.; Seegar, T.; Rogers, J. M.; Bae, M.; Lumpkin, R.; Cao, R.; Henke, M.; Fischer, E. S.; Cuny, G.; Blacklow, S. C.
10.1101/2021.06.02.446786 — biochemistry — Posted on 2021-06-02
3903 Anatomy of an Extensively Drug Resistant Klebsiella pneumoniae Outbreak in Tuscany, Italy
Martin, M. J.; Corey, B. W.; Sannio, F.; Hall, L. R.; MacDonald, U.; Jones, B. T.; Mills, E. G.; Stam, J.; Maybank, R.; Kwak, Y.; Schaufler, K.; Becker, K.; Hubner, N. O.; Cresti, S.; Tordini, G.; Valassina, M.; Cusi, M. G.; Bennett, J. W.; Russo, T. A.; McGann, P. T.; Lebreton, F.; Docquier, J.-D.
10.1101/2021.06.02.446696 — microbiology — Posted on 2021-06-02
3904 Mycobacterium tuberculosis H2S functions as a sink to modulate central metabolism, bioenergetics, and drug susceptibility
Kunota, T. T. R.; Rahman, M. A.; Truebody, B. E.; Mackenzie, J. S.; Saini, V.; Lamprecht, D. A.; Adamson, J. H.; Sevalkar, R. R.; Lancaster, J. R.; Berney, M.; Glasgow, J. N.; Steyn, A. J.
10.1101/2021.06.02.446746 — microbiology — Posted on 2021-06-02
3905 Divergent early antibody responses define COVID-19 disease trajectories
Chakraborty, S.; Gonzalez, J. C.; Sievers, B. L.; Mallajosyula, V.; Dubey, M.; Cheng, Y.-L. B.; Tran, K. Q. T.; Chakraborty, S.; Cassidy, A.; Chen, S. T.; Sinnott, A.; Gelbart, T.; Golan, Y.; Prahl, M.; Singh, U.; Kim-Schulze, S.; Sherwood, R.; Zhang, S.; Marron, T. U.; Gnjatic, S.; Gaw, S. L.; Nadeau, K. C.; Merad, M.; Jagannathan, P.; Tan, G. S.; Wang, T. T.
10.1101/2021.05.25.445649 — immunology — Posted on 2021-06-02
3907 A female-specific role for Calcitonin Gene-Related Peptide (CGRP) in rodent pain models
Paige, C.; Plasencia-Fernandez, I.; Kume, M.; Papalampropoulou-Tsiridou, M.; Lorenzo, L.-E.; Mejia, G. L.; Driskill, C. M.; Ferrini, F. M.; Feldhaus, A.; Garcia-Martinez, L.; Akopian, A. N.; De Koninck, Y.; Dussor, G.; Price, T. J.
10.1101/2021.06.02.446716 — neuroscience — Posted on 2021-06-02
3908 Mouse brain-wide mitochondrial connectivity anchored in gene, brain and behavior
Rosenberg, A.; Saggar, M.; Rogu, P.; Limonges, A. W.; Sandi, C.; Mosharov, E. V.; Dumitriu, D.; Anacker, C.; Picard, M.
10.1101/2021.06.02.446767 — neuroscience — Posted on 2021-06-02
3911 Metabolic dysregulations of cancer cells with metastatic potential
Abdul Kader, S.; Dib, S.; Achka, I. W.; Thareja, G.; Suhre, K.; Rafii, A.; Halama, A.
10.1101/2021.06.02.446725 — cancer biology — Posted on 2021-06-02
3912 Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma
Broestl, L.; Grandison, L.; Shenoy, S.; Tallman, M. M.; Rhee, G.; Yang, W.; Sponagel, J.; Kfoury-Beaumont, N.; Hill, C. M.; Mao, D. D.; Kim, A. H.; Stewart, S. A.; Venere, M.; Luo, J.; Rubin, J. B.
10.1101/2021.06.02.446756 — cancer biology — Posted on 2021-06-02
3913 Tatajuba - Exploring the distribution of homopolymer tracts
de Oliveira Martins, L.; Bloomfield, S.; Stoakes, E.; Grant, A. J.; Page, A. J.; Mather, A.
10.1101/2021.06.02.446710 — bioinformatics — Posted on 2021-06-02
3914 The BLENDS Method for Data Augmentation of 4-Dimensional Brain Images
Nguyen, K. P.; Raval, V.; Minhajuddin, A.; Carmody, T.; Trivedi, M. H.; Dewey, R. B.; Montillo, A.
10.1101/2021.06.02.446748 — bioengineering — Posted on 2021-06-02
3915 Raman spectroscopy reveals phenotype switches in breast cancer metastasis
Paidi, S. K.; Troncoso, J. R.; Harper, M. G.; Liu, Z.; Nguyen, K. G.; Ravindranathan, S.; Ivers, J. D.; Zaharoff, D. A.; Rajaram, N.; Barman, I.
10.1101/2021.06.02.446487 — bioengineering — Posted on 2021-06-02
3916 Interaction of a photochromic UV sensor protein Rc-PYP with PYP-binding protein
Kim, S.; Nakasone, Y.; Takakado, A.; Yamazaki, Y.; Kamikubo, H.; Terazima, M.
10.1101/2021.06.01.446672 — biochemistry — Posted on 2021-06-02
3917 Gene regulatory networks underlying human microglia maturation
Coufal, N. G.; Glass, C.; Han, C.; Li, R. Z.; Hansen, E.; Bennett, H.; Poirion, O.; Buchanan, J.; Challacombe, J.; Fixsen, B.; Trescott, S.; Schlachetzki, J.; Preissl, S.; Wang, A.; O'Connor, C.; Warden, A. S.; Shriram, S.; Kim, R.; Nguyen, C.; Schafer, D.; Ramirez, G.; Anavim, S. A.; Johnson, A.; Sajti, E.; Gupta, M.; Ben-Haim, S.; Gonda, D. D.; Levy, M. L.; Laurent, L.
10.1101/2021.06.02.446636 — genomics — Posted on 2021-06-02
3923 Deep-rooted plant species recruit distinct bacterial communities in 3 m deep subsoil
Bak, F.; Lyhne-Kjaerbye, A.; Tardif, S.; Dresboell, D. B.; Nicolaisen, M. H.
10.1101/2021.06.02.446747 — microbiology — Posted on 2021-06-02
3926 Bacillus velezensis stimulates resident rhizosphere Pseudomonas stutzeri for plant health through metabolic interactions
Sun, X.; Xu, Z.; Xie, J.; Thomsen, V. H.; Tan, T.; Strube, M. L.; Dragos, A.; Shen, Q.; Zhang, R.; Kovacs, A. T.
10.1101/2021.06.02.446779 — microbiology — Posted on 2021-06-02
3927 Naturally enhanced neutralizing breadth to SARS-CoV-2 after one year
Wang, Z.; Muecksch, F.; Schaefer-Babajew, D.; Finkin, S.; Viant, C.; Gaebler, C.; Hoffmann, H.- H.; Barnes, C. O.; Cipolla, M.; Ramos, V.; Oliveira, T. Y.; Cho, A.; Schmidt, F.; Silva, J. D.; Bednarski, E.; Aguado, L.; Yee, J.; Daga, M.; Turroja, M.; Millard, K. G.; Jankovic, M.; Gazumyan, A.; Zhao, Z.; Rice, C. M.; Bieniasz, P. D.; Caskey, M.; Hatziioannou, T.; Nussenzweig, M. C.
10.1101/2021.05.07.443175 — immunology — Posted on 2021-06-02
3937 Hitting more birds with one stone: CD70 as an actionable immunotherapeutic target in recurrent glioblastoma
Seyfrid, M.; Maich, W.; Shaikh, V. M.; Tatari, N.; Upreti, D.; Piyasena, D.; Subapanditha, M.; Savage, N.; McKenna, D.; Kuhlmann, L.; Khoo, A.; Salim, S. K.; Bassey-Archibong, B.; Gwynne, W. D.; Chokshi, C.; Brown, K. R.; Murtaza, N.; Bakhshinyan, D.; Vora, P.; Venugopal, C.; Moffat, J.; Singh, S. K.
10.1101/2021.06.02.446670 — cancer biology — Posted on 2021-06-02
3941 Relative Affinities of Protein-Cholesterol Interactions from Equilibrium Molecular Dynamics Simulations
Ansell, T. B.; Curran, L.; Horrell, M. R.; Pipatpolkai, T.; Letham, S. C.; Song, W.; Siebold, C.; Stansfeld, P. J.; Sansom, M. S. P.; Corey, R. A.
10.1101/2021.06.02.446704 — biophysics — Posted on 2021-06-02
3942 FLAME: a web tool for functional and literature enrichment analysis of multiple gene lists
Thanati, F.; Karatzas, E.; Baltoumas, F.; Stravopodis, D. J.; Eliopoulos, A. G.; Pavlopoulos, G.
10.1101/2021.06.02.446692 — bioinformatics — Posted on 2021-06-02
3947 Acetylated Chromatin Domains Link Chromosomal Organization to Cell- and Circuit-level Dysfunction in Schizophrenia and Bipolar Disorder
Girdhar, K.; Hoffman, G. E.; Bendl, J.; Rahman, S.; Dong, P.; Liao, W.; Brown, L.; Devillers, O.; Kassim, B. S.; Wiseman, J. R.; Park, R.; Zharovsky, E.; Jacobov, R.; Flatow, E.; Kozlenkov, A.; Gilgenast, T.; Johnson, J. S.; Couto, L.; Peters, M. A.; Phillips-Cremins, J. E.; Hahn, C.-G.; Gur, R. E.; Tamminga, C. A.; Lewis, D. A.; Haroutunian, V.; PsychENCODE Consortium, ; Dracheva, S.; Lipska, B. K.; Marenco, S.; Kundakovic, M.; Fullard, J. F.; Jiang, Y.; Roussos, P.; Akbarian, S.
10.1101/2021.06.02.446728 — genomics — Posted on 2021-06-02
3949 Birth Order Differences in Education Are Environmental in Origin
Isungset, M. A.; Freese, J.; Andreassen, O.; Lyngstad, T. H.
10.1101/2021.06.01.446519 — genetics — Posted on 2021-06-02
3951 Genomic evidence that blind cavefishes are not wrecks of ancient life
Policarpo, M.; Laurenti, P.; Garcia-Machado, E.; Metcalfe, C.; Retaux, S.; Casane, D.
10.1101/2021.06.02.446701 — evolutionary biology — Posted on 2021-06-02
3955 In-phase and in-antiphase connectivity in EEG
O'Reilly, C.; Lewis, J. D.; Theilmann, R. J.; Elsabbagh, M.; Townsend, J.
10.1101/2021.05.19.444800 — neuroscience — Posted on 2021-06-02
3956 Species-specific effects of cation channel TRPM4 small-molecule inhibitors
Arullampalam, P.; Preti, B.; Ross-Kaschitza, D.; Lochner, M.; Rougier, J.-S.; Abriel, H.
10.1101/2021.06.01.446517 — pharmacology and toxicology — Posted on 2021-06-02
3963 Independent duplications of the Golgi phosphoprotein 3 oncogene in birds
Opazo, J. C.; Vandewege, M. W.; Gutierrez, J.; Zavala, K.; Vargas-Chacoff, L.; Morera, F. J.; Mardones, G. A.
10.1101/2021.01.31.429031 — evolutionary biology — Posted on 2021-06-02
3965 Blinking fluorescent probes for tubulin nanoscopy in living and fixed cells
Gerasimaite, R.; Bucevicius, J.; Kiszka, K. A.; Kostiuk, G.; Koenen, T.; Lukinavicius, G.
10.1101/2021.06.01.446685 — cell biology — Posted on 2021-06-02
3966 Extremely bright, near-IR emitting spontaneously blinking fluorophores enable ratiometric multicolor nanoscopy in live cells
Tyson, J.; Hu, K.; Zheng, S.; Kidd, P.; Dadina, N.; Chu, L.; Toomre, D.; Bewersdorf, J.; Schepartz, A.
10.1101/2021.06.02.446776 — cell biology — Posted on 2021-06-02
3967 Proteome and functional decline as platelets age in the circulation
Allan, H. E.; Hayman, M. A.; Marcone, S.; Chan, M. V.; Edin, M. L.; Maffucci, T.; Joshi, A.; Menke, L.; Crescente, M.; Mayr, M.; Zeldin, D. C.; Armstrong, P. C.; Warner, T. D.
10.1101/2021.06.02.446106 — cell biology — Posted on 2021-06-02
3968 Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage
Rillo-Bohn, R.; Adilardi, R.; Mitros, T.; Stevens, L.; Avsaroglu, B.; Kohler, S.; Bayes, J.; Wang, C.; Lin, S.; Baskevitch, A. K.; Rokhsar, D. S.; Dernburg, A. F.
10.1101/662049 — cell biology — Posted on 2021-06-02
3977 Mitochondrial One-Carbon Flux has a Growth-Independent Role in Promoting Breast Cancer Metastasis
Kiweler, N.; Delbrouck, C.; Neises, L.; Pozdeev, V. I.; Soriano-Baguet, L.; Xian, F.; Benzarti, M.; Haase, L.; Schmoetten, M.; Jaeger, C.; Noman, M. Z.; Vazquez, A.; Janji, B.; Dittmar, G.; Brenner, D.; Letellier, E.; Meiser, J.
10.1101/2021.05.27.445928 — cancer biology — Posted on 2021-06-02
3978 PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP production
Srinivas, U. S.; Ramachandran, G. K.; Wardyn, J. D.; Hoppe, M. M.; Peng, Y.; Lim, S.; Lee, M. Y.; Peethala, P. C.; An, O.; Shendre, A.; Tan, B. W. Q.; Norbert, T. S. C.; Jaynes, P.; Hu, L.; Jakhar, R.; Sachaphibulkij, K.; Lim, L. H. K.; Crasta, K.; Yang, H.; Tan, P.; Kappei, D.; Yong, W. P.; Tan, D. S. P.; Pervaiz, S.; Bordi, M.; Campello, S.; Tam, W. L.; Frezza, C.; Jeyasekharan, A. D.
10.1101/2021.06.01.446664 — cancer biology — Posted on 2021-06-02
3979 Costs dictate strategic investment in dominance interactions
Dehnen, T.; Papageorgiou, D.; Nyaguthii, B.; Cherono, W.; Penndorf, J.; Boogert, N. J.; Farine, D. R.
10.1101/2021.06.02.446695 — animal behavior and cognition — Posted on 2021-06-02
3983 Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition
Williams, S. A.; Gwilt, M.; Hock, R.; Taylor, C.; Loayza, J.; Stevenson, C. W.; Cassaday, H. J.; Bast, T.
10.1101/2021.06.02.446736 — neuroscience — Posted on 2021-06-02
3985 Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
Matas-Rico, E.; Frijlink, E.; van der Haar Avila, I.; Menegakis, A.; van Zon, M.; Morris, A. J.; Koster, J.; Salgado-Polo, F.; de Kivit, S.; Lanca, T.; Mazzocca, A.; Johnson, Z.; Haanen, J.; Schumacher, T. N.; Perrakis, A.; Verbrugge, I.; van den Berg, J.; Borst, J.; Moolenaar, W. H.
10.1101/2020.02.26.966291 — cancer biology — Posted on 2021-06-02
3986 Formin's nucleation activity influences actin filament length
Zweifel, M. E.; Sherer, L. A.; Mahanta, B.; Courtemanche, N.
10.1101/2021.06.01.446650 — biophysics — Posted on 2021-06-02
3989 Assembly and levels of P-TEFb depend on reversiblephosphorylation of cyclinT1
Huang, F.; Nguyen, T. N. N.; Echeverria, I.; Ramachandran, R.; Cary, D. C.; Paculova, H.; Sali, A.; Weiss, A.; Peterlin, B. M.; Fujinaga, K.
10.1101/2021.05.25.445695 — biochemistry — Posted on 2021-06-02
3994 Plasticity in intrinsic excitability of hypothalamic magnocellular neurosecretory neurons in late-pregnant and lactating rats
Perkinson, M. R.; Augustine, R. A.; Bouwer, G. T.; Brown, E. F.; Cheong, I.; Seymour, A. J.; Fronius, M.; Brown, C. H.
10.1101/2021.06.01.446490 — neuroscience — Posted on 2021-06-02
4002 scRegulocity: Detection of local RNA velocity patterns in embeddings of single cell RNA-Seq data
Serin Harmanci, A.; Harmanci, A. O.; Zhou, X.; Deneen, B.; Rao, G.; Klisch, T.; Patel, A. J.
10.1101/2021.06.01.446674 — bioinformatics — Posted on 2021-06-02
4004 TransportTools: a library for high-throughput analyses of internal voids in biomolecules and ligand transport through them
Brezovsky, J.; Thirunavukarasu, A. S.; Surpeta, B.; Sequeiros-Borja, C. E.; Mandal, N.; Sarkar, D. K.; Dongmo Foumthuim, C. J.; Agrawal, N.
10.1101/2021.06.01.445451 — bioinformatics — Posted on 2021-06-02
4007 Label-free imaging for quality control of cardiomyocyte differentiation
Qian, T.; Heaster, T.; Houghtaling, A.; Sun, K.; Samimi, K.; Skala, M.
10.1101/2021.06.01.446615 — bioengineering — Posted on 2021-06-02
4008 Characterizing Human Mesenchymal Stromal Cells Immune Modulatory Potency Using Targeted Lipidomic Profiling of Sphingolipids
DeVeaux, S. A.; Ogle, M. E.; Vyshnya, S.; Chiappa, N. F.; Leitmann, B.; Rudy, R.; Day, A.; Mortensen, L. J.; Kurtzberg, J.; Roy, K.; Botchwey, E.
10.1101/2021.06.01.446428 — bioengineering — Posted on 2021-06-02
4010 Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes
Alam, M.; Arunagiri, A.; Haataja, L.; Torres, M.; Larkin, D.; Kappler, J.; Jin, N.; Arvan, P.
10.1101/2021.06.01.446633 — cell biology — Posted on 2021-06-02
4011 A pigtailed macaque model for Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus
Broeckel, R.; Feldmann, F.; McNally, K.; Chiramel, A.; Hanley, P.; Lovaglio, J.; Rosenke, R.; Scott, D.; Saturday, G.; Bouamr, F.; Robertson, S.; Best, S.
10.1101/2021.06.01.446549 — microbiology — Posted on 2021-06-02
4012 Catheterized-bladder environment induces hyphal Candida albicans formation, promoting fungal colonization and persistence.
La Bella, A. A.; Andersen, M. J.; Molesan, A.; Stuckey, P. V.; Santiago-Tirado, F. H.; Flores-Mireles, A. L.
10.1101/2021.06.01.446547 — microbiology — Posted on 2021-06-02
4014 Transcriptomic changes highly similar to Alzheimer's disease are observed in a subpopulation of individuals during normal brain aging
Peng, S.; Zeng, L.; Haure-mirande, J.-v.; Wang, M.; Huffman, D. M.; Haroutunian, V.; Ehrlich, M.; Zhang, B.; Tu, Z.
10.1101/2021.06.01.446628 — neuroscience — Posted on 2021-06-02
4015 Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes
Muelbl, M. J.; Glaeser, B.; Shah, A. S.; Chiariello, R.; Nawarawong, N. N.; Stemper, B. D.; Budde, M. D.; Olsen, C. M.
10.1101/2020.11.18.388421 — neuroscience — Posted on 2021-06-02
4016 Intracerebral mechanisms explaining the impact of incidental feedback on mood state and risky choice
Cecchi, R.; Vinckier, F.; Hammer, J.; Marusic, P.; Nica, A.; Rheims, S.; Trebuchon, A.; Barbeau, E.; Denuelle, M.; Maillard, L.; Minotti, L.; Kahane, P.; Pessiglione, M.; Bastin, J.
10.1101/2021.06.01.446610 — neuroscience — Posted on 2021-06-02
4019 OBO Foundry in 2021: Operationalizing Open Data Principles to Evaluate Ontologies
Jackson, R. C.; Matentzoglu, N.; Overton, J. A.; Vita, R.; Balhoff, J. P.; Buttigieg, P. L.; Carbon, S.; Courtot, M.; Diehl, A. D.; Dooley, D.; Duncan, W.; Harris, N. L.; Haendel, M. A.; Lewis, S. E.; Natale, D. A.; Osumi-Sutherland, D.; Ruttenberg, A.; Schriml, L. M.; Smith, B.; Stoeckert, C. J.; Vasilevsky, N. A.; Walls, R. L.; Zheng, J.; Mungall, C. J.; Peters, B.
10.1101/2021.06.01.446587 — bioinformatics — Posted on 2021-06-02
4020 Secondary metabolism drives ecological breadth in the Xylariaceae
Franco, M. E. E.; Wisecaver, J. H.; Arnold, A. E.; Ju, Y.-M.; Slot, J. C.; Ahrendt, S.; Moore, L. P.; Eastman, K. E.; Scott, K.; Konkel, Z.; Mondo, S. J.; Kuo, A.; Hayes, R.; Haridas, S.; Andreopoulos, B.; Riley, R.; LaButti, K.; Pangilinan, J.; Lipzen, A.; Amirebrahimi, M.; Yan, J.; Adam, C.; Keymanesh, K.; Ng, V.; Louie, K.; Northen, T.; Drula, E.; Henrissat, B.; Hsieh, H.-M.; Youens-Clark, K.; Lutzoni, F.; Miadlikowska, J.; Eastwood, D. C.; Hamelin, R. C.; Grigoriev, I. V.; U'Ren, J. M.
10.1101/2021.06.01.446356 — genomics — Posted on 2021-06-02
4022 Chromosome-level de novo genome assembly of Telopea speciosissima (New South Wales waratah) using long-reads, linked-reads and Hi-C
Chen, S. H.; Rossetto, M.; van der Merwe, M.; Lu-Irving, P.; Yap, J.-Y. S.; Sauquet, H.; Bourke, G.; Bragg, J. G.; Edwards, R. J.
10.1101/2021.06.02.444084 — genomics — Posted on 2021-06-02
4023 Mechanisms regulating interindividual epigenetic variability at transposable elements
Costello, K. R.; Leung, A.; Trac, C.; Lee, M.; Basam, M.; Pospisilik, J. A.; Schones, D.
10.1101/2021.06.01.446659 — genomics — Posted on 2021-06-02
4026 Synthetic Antigen Presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.
Cespedes, P. F.; Jainarayanan, A. K.; Fernandez-Messina, L.; Valvo, S.; Saliba, D. G.; Kvalvaag, A.; Kurz, E.; Colin-York, H.; Fritzsche, M.; Yanchun, P.; Dong, T.; Siller-Farfan, J. A.; Dushek, O.; Maj, M.; Sezgin, E.; Peacock, B.; Law, A.; Aubert, D.; Engledow, S.; Attar, M.; Hester, S.; Fisher, R.; Sanchez-Madrid, F.; Dustin, M. L.
10.1101/2021.05.29.445691 — immunology — Posted on 2021-06-02
4027 Theobroma grandiflorum breeding optimization based on repeatability, stability and adaptability information
Chaves, S. F. d. S.; Alves, R. M.; Alves, R. S.; Sebbenn, A. M.; Resende, M. D. V. d.; Dias, L. A. d. S.
10.1101/2021.06.01.446536 — genetics — Posted on 2021-06-02
4028 Immune complex solubility and size govern Fc-gamma receptor responses: A scalable cell-based reporter system
Chen, H.; Maul-Pavicic, A.; Holzer, M.; Salzer, U.; Chevalier, N.; Voll, R. E.; Hengel, H.; Kolb, P.
10.1101/2020.11.11.378232 — immunology — Posted on 2021-06-02
4032 Injectable Progranulin-derivative Atsttrin loaded Protein Engineered Gels for Post Traumatic Osteoarthritis
Katyal, P.; Hettinghouse, A.; Meleties, M.; Chen, C.; Cui, M.; Sun, G.; Hasan, S.; Menon, R.; Lin, B.; Regatte, R.; Liu, C.; Montclare, J. K.
10.1101/2021.05.12.443716 — bioengineering — Posted on 2021-06-02
4033 TrkB agonist antibody delivery to the brain using a TfR1 specific BBB shuttle provides neuroprotection in a mouse model of Parkinson's Disease
Clarke, E.; Sinclair, L.; Fletcher, E. J. R.; Krawczun-Rygmaczewska, A.; Duty, S.; Stocki, P.; Rutowski, J. L.; Doherty, P.; Walsh, F. S.
10.1101/2020.03.12.987313 — neuroscience — Posted on 2021-06-02
4034 Linear causal filtering: definition and theory
Pascual-Marqui, R.; Biscay, R. J.; Bosch-Bayard, J. F.; Faber, P. L.; Achermann, P.; Kinoshita, T.; Kochi, K.
10.1101/2021.05.01.442232 — neuroscience — Posted on 2021-06-02
4037 Signal-based optical map alignment
Akdel, M.; van de Geest, H.; Schijlen, E.; van Rijswijck, I. M. H.; Smid, E. J.; Sanchez-Perez, G.; de Ridder, D.
10.1101/2021.06.01.446540 — bioinformatics — Posted on 2021-06-02
4041 Spatio-temporal control of DNA replication by the pneumococcal cell cycle regulator CcrZ
Gallay, C.; Sanselicio, S.; Anderson, M. E.; Soh, Y. M.; Liu, X.; Stamsas, G. A.; Pelliciari, S.; van Raaphorst, R.; Denereaz, J.; Kjos, M.; Murray, H.; Gruber, S.; Grossman, A. D.; Veening, J.-W.
10.1101/775536 — microbiology — Posted on 2021-06-02
4043 The human language system does not support music processing
Chen, X.; Affourtit, J.; Ryskin, R.; Regev, T. I.; Norman-Haignere, S.; Jouravlev, O.; Malik-Moraleda, S.; Kean, H.; Varley, R.; Fedorenko, E.
10.1101/2021.06.01.446439 — neuroscience — Posted on 2021-06-01
4045 Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
Montero, B. K.; Uddin, W.; Schwensow, N.; Gillingham, M. A. F.; Ratovonamana, Y. R.; Rakotondranary, S. J.; Corman, V.; Drosten, C.; Ganzhorn, J. U.; Sommer, S.
10.1101/2021.06.01.446545 — evolutionary biology — Posted on 2021-06-01
4047 LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice
Zhang, X.; Sun, J.; Lu, Y.; Zhang, J.; Shimada, K.; Noda, T.; Zhao, S.; Koyano, T.; Matsuyama, M.; Zhou, S.; Wu, J.; Ikawa, M.; Liu, M.
10.1101/2021.06.01.446532 — cell biology — Posted on 2021-06-01
4052 Extraction, purification and anti-TMV effects of α (β)-2,7,11-cembratriene-4,6-diol from tobacco leaves
Feng, Y.; Jia, H.; Guan, H.; Zhang, W.; Zhou, Y.; Liu, K.; Wang, Y.; Li, Q.; Chen, W.; Sohail, M. A.; Wang, J.; Huang, S.; Wei, J.
10.1101/2021.06.01.446537 — plant biology — Posted on 2021-06-01
4053 Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition
Winkler, R.; Mägdefrau, A.-S.; Kleemann, M.; Beyer, M.; Linke, K.; Hansen, L.; Schaffer, A.-M.; Hoffmann, M. E.; Poepsel, S.; Heyd, F.; Beli, P.; Möröy, T.; Mahboobi, S.; Krämer, O. H.; Kosan, C.
10.1101/2021.06.01.445760 — cancer biology — Posted on 2021-06-01
4055 Signal-based optical map alignment
Akdel, M.; de Ridder, D.; van de Geest, H.; Schijlen, E.; van Rijswijck, I. M. H.; Smid, E. J.; Sanchez-Perez, G.
10.1101/2021.06.01.446540 — bioinformatics — Posted on 2021-06-01
4056 Ghrelin O-acyltransferase interacts with extracellular peptides and exhibits unexpected cellular localization for a secretory pathway enzyme
Campana, M. B.; Davis, T. R.; Cleverdon, E. R.; Bates, M.; Krishnan, N.; Curtis, E. R.; Childs, M. D.; Morales-Rodriguez, Y.; Sieburg, M.; Hehnly, H.; Luyt, L. G.; Hougland, J.
10.1101/2021.06.01.446150 — biochemistry — Posted on 2021-06-01
4057 HDX-MS optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases
Rathinaswamy, M. K.; Fleming, K. D.; Dalwadi, U.; Pardon, E.; Harris, N. J.; Yip, C. K.; Steyaert, J.; Burke, J. E.
10.1101/2021.06.01.446614 — biochemistry — Posted on 2021-06-01
4060 ANALYSIS OF CHD-7 DEFECTIVE DAUER NEMATODES IMPLICATES COLLAGEN MISREGULATION IN CHARGE SYNDROME FEATURES.
Jofre, D. M.; Hoffman, D.; Cervino, A.; Grundy, M.; Yun, S.; Gandhi Amrit, F. R.; Stolz, D. B.; Salvatore, E.; Rossi, F. A.; Ghazi, A.; Cirio, M. C.; Yanowitz, J. L.; Hochbaum, D.
10.1101/2021.03.26.437191 — genetics — Posted on 2021-06-01
4062 First evidence of SARS-CoV-2 genome detection in zebra mussel (Dreissena polymorpha).
Le Guernic, A.; Palos Ladeiro, M.; Boudaud, N.; Do Nascimento, J.; Gantzer, C.; Inglard, J.-C.; Mouchel, J.-M.; Pochet, C.; Moulin, L.; Rocher, V.; Waldman, P.; Wurtzer, S.; Geffard, A.
10.1101/2021.05.28.446136 — ecology — Posted on 2021-06-01
4065 Structural mechanism of GTPase-powered ribosome-tRNA movement
Petrychenko, V.; Peng, B.-Z.; Schwarzer, A. C. d. A. P.; Peske, F.; Rodnina, M. V.; Fischer, N.
10.1101/2021.06.01.446629 — molecular biology — Posted on 2021-06-01
4067 SARS-CoV-2 Spreads through Cell-to-Cell Transmission
Zeng, C.; Evans, J. P.; King, T.; Zheng, Y.-M.; Oltz, E. M.; Whelan, S. P. J.; Saif, L.; Peeples, M. E.; Liu, S.-L.
10.1101/2021.06.01.446579 — microbiology — Posted on 2021-06-01
4070 Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline
Sullivan, J. R.; Lupien, A.; Kalthoff, E.; Hamela, C.; Taylor, L.; Munro, K. A.; Schmeing, T. M.; Kremer, L.; Behr, M. A.
10.1101/2021.06.01.446617 — microbiology — Posted on 2021-06-01
4071 SARS coronavirus vaccines protect against different coronaviruses
Dangi, T.; Palacio, N.; Sanchez, S.; Class, J.; Visvabharathy, L.; Ciucci, T.; Koralnik, I.; Richner, J.; Penaloza-MacMaster, P.
10.1101/2021.06.01.446491 — immunology — Posted on 2021-06-01
4073 An N-terminal Fusion Allele to Study Melanin Concentrating Hormone Receptor 1
Jasso, K. R.; Kamba, T. K.; Zimmerman, A. D.; Bansal, R.; Engle, S.; Everett, T.; Wu, C.-H.; Kulaga, H.; Reed, R.; Berbari, N. F.; McIntyre, J. C.
10.1101/2021.04.23.440964 — neuroscience — Posted on 2021-06-01
4074 A multi-tiered map of EMT defines major transition points and identifies vulnerabilities
Paul, I.; Bolzan, D.; Hook, H.; Youssef, A.; Karemore, G.; Oliphant, M. U.; Lin, W.; Liu, Q.; Phanse, S.; White, C.; Padhorny, D.; Kotelnikov, S.; Andrieu, G.; Hu, P.; Denis, G. V.; Kozakov, D.; Raught, B.; Siggers, T.; Wuchty, S.; Muthuswamy, S.; Emili, A.
10.1101/2021.06.01.446492 — systems biology — Posted on 2021-06-01
4077 An interpretable classification method for predicting drug resistance in M. tuberculosis
Zabeti, H.; Dexter, N.; Safari, A. H.; Sedaghat, N.; Libbrecht, M. W.; Chindelevitch, L.
10.1101/2020.05.31.115741 — bioinformatics — Posted on 2021-06-01
4078 RENANO: a REference-based compressor for NANOpore FASTQ files
Dufort y Alvarez, G.; Seroussi, G.; Smircich, P.; Sotelo, J. R.; Ochoa, I.; Martin, A.
10.1101/2021.03.26.437155 — bioinformatics — Posted on 2021-06-01
4080 Micro-Meta App: an interactive software tool to facilitate the collection of microscopy metadata based on community-driven specifications
Rigano, A.; Ehmsen, S.; Ozturk, S. U.; Ryan, J.; Balashov, A.; Hammer, M.; Kirli, K.; Bellve, K.; Boehm, U.; Brown, C. M.; Chambers, J. J.; Coleman, R. A.; Cosolo, A.; Faklaris, O.; Fogarty, K.; Guilbert, T.; Hamacher, A. B.; Itano, M. S.; Keeley, D. P.; Kunis, S.; Lacoste, J.; Laude, A.; Ma, W.; Marcello, M.; Montero-Llopis, P.; Nelson, G.; Nitschke, R.; Pimentel, J. A.; Weidtkamp-Peters, S.; Park, P. J.; Alver, B.; Grunwald, D.; Strambio-De-Castillia, C.
10.1101/2021.05.31.446382 — bioinformatics — Posted on 2021-06-01
4081 A molecular toolbox for ADP-ribosyl binding proteins
Sowa, S. T.; Galera-Prat, A.; Wazir, S.; Alanen, H. I.; Maksimainen, M. M.; Lehtio, L.
10.1101/2021.05.31.445082 — biochemistry — Posted on 2021-06-01
4082 Structure of the phosphoinositide 3-kinase p110γ-p101 complex reveals molecular mechanism of GPCR activation
Rathinaswamy, M. K.; Dalwadi, U.; Fleming, K. D.; Adams, C.; Stariha, J. T.; Pardon, E.; Baek, M.; Vadas, O.; DiMaio, F.; Steyaert, J.; Hansen, S. D.; Yip, C. K.; Burke, J. E.
10.1101/2021.06.01.446612 — biochemistry — Posted on 2021-06-01
4083 Biochemical insight into novel Rab-GEF activity of the mammalian TRAPPIII complex
Harris, N. J.; Jenkins, M. L.; Dalwadi, U.; Fleming, K. D.; Nam, S.-E.; Parson, M. A.; Yip, C. K.; Burke, J. E.
10.1101/2021.06.01.446621 — biochemistry — Posted on 2021-06-01
4084 Mitochondrial Contact Site and Cristae Organizing System (MICOS) Machinery Supports Heme Biosynthesis by Enabling Optimal Performance of Ferrochelatase
Dietz, J. V.; Willoughby, M. M.; Piel, R. B.; Ross, T. A.; Bohovych, I.; Addis, H. G.; Fox, J. L.; Lanzilotta, W. N.; Dailey, H. A.; Wohlschlegel, J. A.; Reddi, A. R.; Medlock, A. E.; Khalimonchuk, O.
10.1101/2021.06.01.446600 — biochemistry — Posted on 2021-06-01
4085 Distinct phosphorylation signals drive acceptor versus self-ubiquitination selection by Parkin
Dunkerley, K. M.; Rintala-Dempsey, A. C.; Salzano, G.; Tadayon, R.; Hadi, D.; Barber, K. R.; Walden, H.; Shaw, G. S.
10.1101/2021.06.01.446590 — biochemistry — Posted on 2021-06-01
4086 Characterization of SARS2 Nsp15 Nuclease Activity Reveals it's Mad About U
Frazier, M. N.; Dillard, L. B.; Krahn, J. M.; Perera, L.; Williams, J. G.; Wilson, I. M.; Stewart, Z. D.; Pillon, M. C.; Deterding, L. J.; Borgnia, M. J.; Stanley, R. E.
10.1101/2021.06.01.446181 — biochemistry — Posted on 2021-06-01
4087 Endomembrane systems are reorganized by ORF3a and Membrane (M) of SARS-CoV-2
Lee, Y.-B.; Jung, M.; Kim, J.; Kang, M.-G.; Kwak, C.; Kim, J.-S.; Mun, J.-Y.; Rhee, H.-W.
10.1101/2021.06.01.446555 — biochemistry — Posted on 2021-06-01
4088 Analysis of SARS-CoV-2 mutations reveals three types of temporal dynamics and one is correlated with international travels
Justo Arevalo, S.; Zapata Sifuentes, D.; Huallpa, C. J.; Landa Bianchi, G.; Castillo Chavez, A.; Garavito-Salini Casas, R.; Uribe Calampa, C. S.; Uceda-Campos, G.; Pineda Chavarria, R.
10.1101/2021.06.01.446571 — genomics — Posted on 2021-06-01
4089 Identification of Discriminative Gene-level and Protein-level Features Associated with Gain-of-Function and Loss-of-Function Mutations
Sevim Bayrak, C.; Jain, A.; Stein, D.; Chaudhary, K.; Nadkarni, G.; Van Vleck, T. T.; Puel, A.; Boisson-Dupuis, S.; Okada, S.; Stenson, P.; Cooper, D. N.; Schlessinger, A. N.; Itan, Y.
10.1101/2021.01.01.424981 — genetics — Posted on 2021-06-01
4091 Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex
Biehler, C.; Rothenberg, K. E.; Jette, A.; Gaude, H.-M.; Fernandez-Gonzalez, R.; Laprise, P.
10.1101/2021.01.05.425461 — cell biology — Posted on 2021-06-01
4092 3-hydroxyanthranilic acid - a new metabolite for healthy lifespan extension
Dang, H.; Castro-Portuguez, R.; Espejo, L.; Backer, G.; Freitas, S.; Spence, E.; Meyers, J.; Shuck, K.; Corban, C.; Liu, T.; Bean, S.; Sheehan, S.; Korstanje, R.; Sutphin, G. L.
10.1101/2021.06.01.446651 — molecular biology — Posted on 2021-06-01
4093 SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization
Jackson, L.; Rodel, H.; Hwa, S.-H.; Cele, S.; Ganga, Y.; Tegally, H.; Bernstein, M.; Giandhari, J.; COMMIT-KZN Team, ; Gosnell, B. I.; Khan, K.; Hanekom, W.; Karim, F.; de Oliveira, T.; Moosa, M.-Y. S.; Sigal, A.
10.1101/2021.06.01.446516 — microbiology — Posted on 2021-06-01
4095 Synergistic inhibition of two host factors that facilitate entry of Severe Acute Respiratory Syndrome Coronavirus 2
Kreutzberger, A. J. B.; Sanyal, A.; Ojha, R.; Pyle, J.; Vapalahti, O.; Balistreri, G.; Kirchhausen, T.
10.1101/2021.06.01.446623 — microbiology — Posted on 2021-06-01
4101 A mitochondrial long-chain fatty acid oxidation defect leads to uncharged tRNA accumulation and activation of the integrated stress response in the mouse heart
Ranea-Robles, P.; Pavlova, N. N.; Bender, A.; Pereyra, A. S.; Ellis, J. M.; Stauffer, B.; Yu, C.; Thompson, C. B.; Argmann, C.; Puchowicz, M. A.; Houten, S. M.
10.1101/2021.05.13.443905 — physiology — Posted on 2021-06-01
4112 Structural basis for cell-type specific evolution of viral fitness by SARS-CoV-2
Gupta, K.; Toelzer, C.; Williamson, M. K.; Shoemark, D.; Oliveira, A. S. F.; Matthews, D. A.; Almuqrin, A.; Staufer, O.; Yadav, S. K. N.; Borucu, U.; Garzoni, F.; Fitzgerald, D.; Spatz, J.; Mulholland, A. J.; Davidson, A. D.; Schaffitzel, C.; Berger, I.
10.1101/2021.05.11.443384 — molecular biology — Posted on 2021-06-01
4113 Inducible and reversible inhibition of miRNA-mediated gene repression in vivo
La Rocca, G.; King, B.; Shui, B.; Li, X.; Zhang, M.; Akat, K.; Ogrodowski, P.; Mastroleo, C.; Chen, K.; Cavalieri, V.; Ma, Y.; Anelli, V.; Betel, D.; Vidigal, J. A.; Tuschl, T.; Meister, G.; Thompson, C. B.; Lindsten, T.; Haigis, K. M.; Ventura, A.
10.1101/2021.06.01.445680 — molecular biology — Posted on 2021-06-01
4120 Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases
Chen, X.; Hughes, R.; Mullin, N.; Hawkins, R. J.; Holen, I.; Brown, N. J.; Hobbs, J. K.
10.1101/2021.06.01.446539 — cancer biology — Posted on 2021-06-01
4125 The draft chromosome-level genome assembly of tetraploid ground cherry (Prunus fruticosa Pall.) from long reads
Woehner, T. W.; Emeriewen, O. F.; Wittenberg, A.; Schneiders, H.; Vrijenhoek, I.; Halasz, J.; Hrotko, K.; Hoff, K. J.; Gabriel, L.; Keilwagen, J.; Berner, T.; Schuster, M.; Peil, A.; Wuensche, J.; Kropop, S.; Flachowsky, H.
10.1101/2021.06.01.446499 — genomics — Posted on 2021-06-01
4126 Genetic and pharmacological causes of germline hypermutation
Kaplanis, J.; Ide, B.; Sanghvi, R.; Neville, M.; Danecek, P.; Prigmore, E.; Short, P.; Gallone, G.; McRae, J.; Odhams, C.; Moutsianas, L.; Genomics England Research Consortium, ; Carmichael, J.; Barnicoat, A.; Firth, H.; O'Brien, P.; Rahbari, R.; Hurles, M. E.
10.1101/2021.06.01.446180 — genomics — Posted on 2021-06-01
4128 Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas
Borner, K.; Teichmann, S. A.; Quardokus, E. M.; Gee, J.; Browne, K.; Osumi-Sutherland, D.; Herr, B. W.; Bueckle, A.; Paul, H.; Haniffa, M. A.; Jardine, L.; Bernard, A.; Ding, S.-L.; Miller, J. A.; Lin, S.; Halushka, M.; Boppana, A.; Longacre, T. A.; Hickey, J.; Lin, Y.; Valerius, M. T.; He, Y.; Pryhuber, G.; Sun, X.; Jorgensen, M.; Radtke, A.; Wasserfall, C.; Ginty, F.; Ho, J.; Sunshine, J.; Beuschel, R. T.; Brusko, M.; Lee, S.; Malhotra, R.; Jain, S.; Weber, G.
10.1101/2021.05.31.446440 — cell biology — Posted on 2021-06-01
4129 Proteome of actin stress fibers
Liu, S.; Matsui, T. S.; Kang, N.; Deguchi, S.
10.1101/2021.06.01.446528 — cell biology — Posted on 2021-06-01
4130 Bacterial predation on T4 phages
godon, j.-j.; bize, a.; ngo, h.; cauquil, l.; almeida, m.; petit, m.-a.; zemb, o.
10.1101/2021.06.01.446436 — microbiology — Posted on 2021-06-01
4132 Discovery, diversity and functional associations of crAss-like phages in human gut metagenomes from four Dutch cohorts
Gulyaeva, A.; Garmaeva, S.; Ruigrok, R. A. A. A.; Wang, D.; Riksen, N. P.; Netea, M. G.; Wijmenga, C.; Weersma, R. K.; Fu, J.; Vich Vila, A.; Kurilshikov, A.; Zhernakova, A.
10.1101/2021.06.01.446427 — microbiology — Posted on 2021-06-01
4133 Gene Expression Associated with Individual Variability in Intrinsic Functional Connectivity
Li, L.; Wei, Y.; Zhang, J.; Ma, J.; Yi, Y.; Gu, Y.; Li, L. M. W.; Lin, Y.; Dai, Z.
10.1101/2021.06.01.446504 — neuroscience — Posted on 2021-06-01
4135 Spatial and temporal autocorrelation weave human brain networks
Shinn, M.; Hu, A.; Turner, L.; Noble, S.; Achard, S.; Anticevic, A.; Scheinost, D.; Constable, R. T.; Lee, D.; Bullmore, E. T.; Murray, J. D.
10.1101/2021.06.01.446561 — neuroscience — Posted on 2021-06-01
4140 High-throughput discovery of peptide activators of a bacterial sensor kinase
Brink, K. R.; Mu, A. M.; Hoang, K. V.; Groszman, K.; Gunn, J. S.; Tabor, J. J.
10.1101/2021.06.01.446581 — synthetic biology — Posted on 2021-06-01
4141 The liverwort Marchantia polymorpha operates a depolarization-activated Slowpoke (SLO) K+ channel that recognises pH changes in the environment
Sussmilch, F. C.; Boehm, J.; Gessner, G.; Maierhofer, T.; Mueller, T. D.; Heinemann, S. H.; Becker, D.; Hedrich, R.
10.1101/2021.06.01.446568 — plant biology — Posted on 2021-06-01
4143 Integrated Multi-Omics Data Reveals the Molecular Subtypes of Prostate Cancer
Meng, J.; Lu, X.; Jin, C.; Zhou, Y.; Ge, Q.; Zhang, M.; Zhou, J.; Hao, Z.; Yan, F.; Liang, C.
10.1101/2021.05.31.446411 — cancer biology — Posted on 2021-06-01
4145 Tracking-based rolling angles recovery method for holographic tomography of flowing cells
Pirone, D.; Memmolo, P.; Merola, F.; Miccio, L.; Mugnano, M.; Capozzoli, A.; Curcio, C.; Liseno, A.; Ferraro, P.
10.1101/2021.06.01.446558 — bioengineering — Posted on 2021-06-01
4146 Song preferences predict the quality of vocal learning in zebra finches
Rodriguez-Saltos, C. A.; Bhise, A.; Karur, P.; Khan, R. N.; Lee, S.; Ramsay, G.; Maney, D. L.
10.1101/2021.06.01.446570 — animal behavior and cognition — Posted on 2021-06-01
4148 Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
Rausser, S.; Trumpff, C.; McGill, M. A.; Junker, A.; Wang, W.; Ho, S.-H.; Mitchell, A.; Karan, K. R.; Monk, C.; Segerstrom, S. C.; Reed, R. G.; Picard, M.
10.1101/2020.10.16.342923 — cell biology — Posted on 2021-06-01
4149 Sensory coding and causal impact of mouse cortex in a visual decision
Zatka-Haas, P.; Steinmetz, N. A.; Carandini, M.; Harris, K. D.
10.1101/501627 — neuroscience — Posted on 2021-06-01
4151 Heterogeneity and molecular programming of progenitors for motor neurons and oligodendrocytes
Xing, L.; Chai, R.; wang, j.; Lin, J.; Li, H.; Wang, Y.; Lai, B.; sun, j.; Chen, G.
10.1101/2021.06.01.446521 — neuroscience — Posted on 2021-06-01
4152 Genome-wide cis-decoding for expression designing in tomato using cistrome data and explainable deep learning
Akagi, T.; Masuda, K.; Kuwada, E.; Takeshita, K.; Kawakatsu, T.; Ariizumi, T.; Kubo, Y.; Ushijima, K.; Uchida, S.
10.1101/2021.06.01.446518 — plant biology — Posted on 2021-06-01
4156 Genomic taxonomic assignment of individual root-knot nematodes
Sellers, G. S.; Jeffares, D. C.; Lawson, B.; Prior, T.; Lunt, D. H.
10.1101/2021.03.18.435936 — genomics — Posted on 2021-06-01
4157 Genome archaeology of two laboratory Salmonella enterica enterica sv Typhimurium
Zaworski, J.; Dagva, O.; Kingston, A. W.; Fomenkov, A.; Morgan, R. D.; Bossi, L.; Raleigh, E. A.
10.1101/2021.04.07.438813 — genomics — Posted on 2021-06-01
4162 Cryo-EM structures of human RNA polymerase I
Misiaszek, A. D.; Girbig, M.; Grötsch, H.; Baudin, F.; Lafita, A.; Murciano, B.; Müller, C. W.
10.1101/2021.05.31.446457 — molecular biology — Posted on 2021-06-01
4164 3D atlas of the pituitary gland of the model fish medaka
Royan, M. R.; Siddique, K.; Csucs, G.; Puchades, M. A.; Nourizadeh-Lillabadi, R.; Bjaalie, J. G.; Henkel, C.; Weltzien, F.-A.; FONTAINE, R.
10.1101/2021.05.31.446412 — neuroscience — Posted on 2021-06-01
4166 A multi-tiered map of EMT defines major transition points and identifies vulnerabilities
Paul, I.; Bolzan, D.; Hook, H.; Youssef, A.; Karemore, G.; Oliphant, M. U.; Lin, W.; Liu, Q.; Phanse, S.; White, C.; Padhorny, D.; Kotelnikov, S.; Andrieu, G.; Hu, P.; Denis, G. V.; Kozakov, D.; Raught, B.; Siggers, T.; Wuchty, S.; Muthuswamy, S.; Emili, A.
10.1101/2021.06.01.446492 — systems biology — Posted on 2021-06-01
4173 PGfinder, a novel analysis pipeline for the consistent, reproducible and high- resolution structural analysis of bacterial peptidoglycans
Patel, A. V.; Turner, R. D.; Rifflet, A.; Acosta-Martin, A. E.; Nichols, A.; Awad, M. M.; Lyras, D.; Gomperts Boneca, I.; Bern, M.; Collins, M.; Mesnage, S.
10.1101/2021.06.01.446515 — microbiology — Posted on 2021-06-01
4182 Phylogenetic context using phylogenetic outlines
Bagci, C.; Bryant, D. J.; Cetinkaya, B.; Huson, D. H.
10.1101/2021.05.31.446453 — bioinformatics — Posted on 2021-06-01
4185 Phenotypic and transcriptomic analyses reveal major differences between apple and pear scab nonhost resistance
VERGNE, E.; CHEVREAU, E.; RAVON, E.; GAILLARD, S.; PELLETIER, S.; BAHUT, M.; PERCHEPIED, L.
10.1101/2021.06.01.446506 — genomics — Posted on 2021-06-01
4188 Homothorax Controls a Binary Rhodopsin Switch in Drosophila Ocelli
Mishra, A. K.; Fritsch, C.; Voutev, R.; Mann, R. S.; Sprecher, S. G.
10.1101/2021.03.04.433862 — genetics — Posted on 2021-06-01
4189 Identifying drivers of spatio-temporal variation in survival in four blue tit populations
Bastianelli, O.; Robert, A.; Doutrelant, C.; de Franceschi, C.; Giovannini, P.; Charmantier, A.
10.1101/2021.01.28.428563 — ecology — Posted on 2021-06-01
4192 MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data
Cmero, M.; Schmidt, B.; Majewski, I. J.; Ekert, P. G.; Oshlack, A.; Davidson, N. M.
10.1101/2020.06.03.131532 — bioinformatics — Posted on 2021-06-01