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Archive, 2022-07

2 Expansion Sequencing of RNA Barcoded Neurons in the Mammalian Brain: Progress and Implications for Molecularly Annotated Connectomics
Goodwin, D. R.; Vaughan, A.; Leible, D.; Alon, S.; Henry, G. L.; Cheng, A. V.; Chen, X.; Zhang, R.; Xue, A. G.; Wassie, A. T.; Sinha, A.; Bando, Y.; Kajita, A.; Marblestone, A. H.; Zador, A. M.; Boyden, E. S.; Church, G. M.; Kohman, R. E.
10.1101/2022.07.31.502046 — neuroscience — Posted on 2022-07-31
5 Optogenetic Targeting of AII Amacrine Cells restores Retinal Computations performed by the Inner Retina
Khabou, H.; Orendorff, E.; Trapani, F.; Rucli, M.; Desrosiers, M.; Yger, P.; Dalkara, D.; Marre, O.
10.1101/2022.07.28.501925 — neuroscience — Posted on 2022-07-31
6 Drug-gene interaction screens coupled to tumour data analyses identify the most clinically-relevant cancer vulnerabilities driving sensitivity to PARP inhibition
Jamal, K.; Galbiati, A.; Armenia, J.; Illuzzi, G.; Hall, J.; Bentouati, S.; Barrell, D.; Ahdesmäki, M.; Functional Genomics Centre, ; O'Connor, M. J.; Leo, E.; Forment, J. V.
10.1101/2022.07.29.501846 — cancer biology — Posted on 2022-07-31
10 Identify non-mutational p53 loss of function in human cancers
Li, Q.; Zhang, Y.; Zhang, Z.; Oberg, A.; Kozono, D.; Lu, H.; Sarkaria, J. N.; Ma, L.; Wang, L.
10.1101/2022.07.28.501874 — bioinformatics — Posted on 2022-07-31
12 Candidate proteins associated with popping expansion capacity of popcorn
Gemelli, T. M. d. C. J.; Romani, I.; Santos, N. F.; Machado, M. d. F. P. S.; Scapim, C. A.; Domont, G. B.; Nogueira, F. C. S.; Gonela, A.
10.1101/2022.07.30.502124 — genomics — Posted on 2022-07-31
17 Collective invasion of the basement membrane in breast cancer driven by forces from cell volume expansion and local contractility
Chang, J.; Saraswathibhatla, A.; Song, Z.; Varma, S.; Sanchez, C.; Srivastava, S.; Liu, K.; Bassik, M. C.; Marinkovich, M. P.; Hodgson, L.; Shenoy, V.; West, R. B.; Chaudhuri, O.
10.1101/2022.07.28.501930 — cancer biology — Posted on 2022-07-31
19 JBrowse 2: A modular genome browser with views of synteny and structural variation
Diesh, C.; Stevens, G. J.; Xie, P.; Martinez, T. D. J.; Hershberg, E. A.; Leung, A.; Guo, E.; Dider, S.; Zhang, J.; Bridge, C.; Hogue, G.; Duncan, A.; Morgan, M.; Flores, T.; Bimber, B. N.; Haw, R.; Cain, S.; Buels, R. M.; Stein, L. D.; Holmes, I.
10.1101/2022.07.28.501447 — bioinformatics — Posted on 2022-07-31
21 Light-dependent Control of Bacterial Expression at the mRNA Level
Ranzani, A.; Wehrmann, M.; Kaiser, J.; Juraschitz, M.; Weber, A.; Pietruschka, G.; Mayer, G.; Moeglich, A.
10.1101/2022.07.30.502174 — biochemistry — Posted on 2022-07-31
22 Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples
Cai, F.; Bezwada, D. J.; Cai, L.; Mahar, R.; Wu, Z.; Pachnis, P.; Yang, C.; Kelekar, S.; Gu, W.; Vu, H. S.; Mathews, T. P.; Zacharias, L. G.; Martin-Sandoval, M.; Do, D.; Oaxaca, K. C.; Jin, E. S.; Margulis, V.; Malloy, C. R.; Merritt, M. E.; DeBerardinis, R. J.
10.1101/2022.07.31.502208 — biochemistry — Posted on 2022-07-31
24 Loss of function variants in DNAJB4 cause a myopathy with early respiratory failure
Weihl, C. C.; Topf, A.; Bengoechea, R.; Duff, J.; Mroczek, M.; Charlton, R.; Garcia, S. K.; Alsaman, A.; Hernandez-Lain, A.; VaronaFranco, L.; Ponce Sanchez, M. E.; Olive, M.; Beecroft, S. J.; Goulee, H.; Daw, J.; Bhadra, A.; True, H.; Inoue, M.; Findlay, A.; Laing, N.; Ravenscroft, G.; Straub, V.
10.1101/2022.07.31.502226 — genetics — Posted on 2022-07-31
28 Lipid Desaturation Regulates the Balance between Self-renewal and Differentiation in Mouse Blastocyst-derived Stem Cells
Thomas, C.; Haimson, R. B.; Zacharia, A.; Orih, P.; Shehadeh, A.; Saidemberg, D.; Kogan, N. M.; Alfandary, S.; Serruya, R.; Dagan, A.; Petit, I.; Moussaieff, A.
10.1101/2022.07.28.501839 — developmental biology — Posted on 2022-07-31
31 Type 17 Follicular Helper T (Tfh17) Cells are Superior for Memory Maintenance
Gao, X.; Luo, K.; Wang, D.; Wei, Y.; Yao, Y.; Deng, J.; Yang, Y.; Zeng, Q.; Dong, X.; Xiong, L.; Gong, D.; Lin, L.; Pohl, K.; Liu, S.; Liu, Y.; Liu, L.; Nguyen, T. H. O.; Allen, L. F.; Kedzierska, K.; Jin, Y.; Du, M.-R.; Chen, W.; Lu, L.; Shen, N.; Liu, Z.; Cockburn, I.; Luo, W.; Yu, D.
10.1101/2022.07.31.502219 — immunology — Posted on 2022-07-31
33 Integrated transcriptome analysis of Huntingtons disease iPSC-derived and mouse astrocytes implicates dysregulated synaptogenesis, actin, and astrocyte maturation
Reyes-Ortiz, A. M.; Abud, E. M.; Burns, M. S.; Wu, J.; Hernandez, S. J.; Geller, N.; Wang, K. Q.; Schulz, C.; Miramontes, R.; Lau, A.; Michael, N.; Miyoshi, E.; Blurton-Jones, M.; Van Vactor, D.; Reidling, J. C.; Swarup, V.; Poon, W. W.; Lim, R. G.; Thompson, L. M.
10.1101/2022.07.28.501170 — neuroscience — Posted on 2022-07-31
34 Radiogenomics of C9orf72 expansion carriers reveals global transposable element de-repression and enables prediction of thalamic atrophy and clinical impairment
Bonham, L. W.; Geier, E. G.; Sirkis, D. W.; Leong, J. K.; Ramos, E. M.; Wang, Q.; Karydas, A.; Lee, S. E.; Sturm, V. E.; Sawyer, R. P.; Friedberg, A.; Ichida, J. K.; Gitler, A. D.; Sugrue, L.; Cordingley, M.; Bee, W.; Weber, E.; Kramer, J.; Rankin, K. P.; Rosen, H. J.; Boxer, A. L.; Seeley, W. W.; Ravits, J.; Miller, B. L.; Yokoyama, J. S.
10.1101/2022.07.28.501897 — neuroscience — Posted on 2022-07-31
39 Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue
Kumar, S.; Basto, A.; Ribeiro, F.; Almeida, S. S. C. P.; Campos, P.; Peres, C.; Al-Khalidi, S.; Kilbey, A.; Tosello, J.; Piaggio, E.; Russo, M.; Gama-Carvalho, M.; Coffelt, S. B.; Roberts, E. W.; Florindo, H.; Graca, L.
10.1101/2022.07.28.501817 — immunology — Posted on 2022-07-31
42 Downregulation of Extraembryonic Tension Controls Body Axis Formation in Avian Embryos
Kunz, D.; Wang, A.; Chan, C. U.; Pritchard, R. H.; Wang, W.; Gallo, F.; Bradshaw, C. R.; Terenzani, E.; Müller, K. H.; Huang, Y. Y. S.; Xiong, F.
10.1101/2021.02.24.432525 — developmental biology — Posted on 2022-07-31
45 Ena/VASP proteins at the crossroads of actin nucleation pathways in dendritic cell migration
Visweshwaran, S. P.; Nayab, H.; Hoffmann, L.; Gil, M.; Liu, F.; Kuehne, R.; Maritzen, T.
10.1101/2022.07.29.501881 — cell biology — Posted on 2022-07-31
46 An ERAD-independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis
Bhaduri, S.; Aguayo, A.; Ohno, Y.; Proietto, M.; Jung, J.; Wang, I.; Kandel, R.; Singh, N.; Ibrahim, I.; Fulzele, A.; Bennett, E. J.; Kihara, A.; Neal, S. E.
10.1101/2022.07.30.502165 — cell biology — Posted on 2022-07-31
47 Cryo-electron tomography reveals enrichment and identifies microtubule lumenal particles in neuronal differentiation
Chakraborty, S.; Martinez-Sanchez, A.; Beck, F.; Toro-Nahuelpan, M.; Hwang, I.-Y.; Noh, K.-M.; Baumeister, W.; Mahamid, J.
10.1101/2022.07.28.501854 — cell biology — Posted on 2022-07-31
48 Epidermis derived lactate promotes sterile inflammation by inducing metabolic rewiring in macrophages.
Ayyangar, U.; Karkhanis, A.; Tay, H.; Afandi, A. F. B.; Bhattacharjee, O.; Lee, S. H.; Chan, J.; Raghavan, S.
10.1101/2022.07.29.501937 — cell biology — Posted on 2022-07-31
50 Single Cell Cortical Bone Transcriptomics Defines Novel Osteolineage Gene Sets Altered in Chronic Kidney Disease
Agoro, R.; Nookaew, I.; Noonan, M.; Marambio, Y. G.; Liu, S.; Chang, W.; Gao, H.; Horan, D.; Thompson, W. R.; Xuei, X.; Liu, Y.; Zhang, C.; Robling, A. G.; Bonewald, L. F.; Wan, J.; White, K. E.
10.1101/2022.07.30.502024 — cell biology — Posted on 2022-07-31
51 Propagation dynamics of electrotactic motility in large epithelial cell sheets
Zhang, Y.; Xu, G.; Wu, J.; Lee, R. M.; Zhu, Z.; Sun, Y.; Zhu, K.; Losert, W.; Liao, S.; Zhang, G.; Pan, T.; Xu, Z.; Lin, F.; Zhao, M.
10.1101/2022.07.30.502112 — cell biology — Posted on 2022-07-31
52 Dually targeted proteins regulate proximity between peroxisomes and partner organelles
Stehlik, T.; Bittner, E.; Lam, J.; Dimitrov, L.; Schöck, I.; Harberding, J.; Heymons, N.; Schuldiner, M.; Zalckvar, E.; Bölker, M.; Schekman, R.; Freitag, J.
10.1101/2022.07.29.501968 — cell biology — Posted on 2022-07-31
54 Sex and BDNF Val66Met Polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice
Islas, D.; Splinter, T. F.; Ibrahim, M.; Black, N.; Wong, S.; Liu-Ambrose, T.; Barha, C. K.; Galea, L.
10.1101/2022.07.29.502070 — neuroscience — Posted on 2022-07-31
55 A molecular mechanism for membrane chaperoning by a late embryogenesis abundant protein
Li, X.-H.; Yu, C. W. H.; Gomez-Navarro, N.; Stancheva, V.; Zhu, H.; Guibao, C.; Xie, B.; Murthy, A.; Wozny, M.; Leslie, B.; Kaminski, M.; Malhotra, K.; Johnson, C. M.; Blackledge, M.; Santhanam, B.; Green, D. R.; Peng, J.; Liu, W.; Huang, J.; Miller, E. A.; Freund, S. M. V.; Babu, M. M.
10.1101/2022.07.29.502075 — biophysics — Posted on 2022-07-31
57 Nuclear myosin VI maintains replication fork stability
Shi, J.; Hauschulte, K.; Mikicic, I.; Maharjan, S.; Arz, V.; Heidelberger, J. B.; Schaefer, J. V.; Dreier, B.; Plueckthun, A.; Beli, P.; Ulrich, H. D.; Wollscheid, H.-P.
10.1101/2022.07.28.501567 — cell biology — Posted on 2022-07-31
59 Cell surface receptors TREM2, CD14 and integrin αMβ2 drive sinking engulfment in phosphatidylserine-mediated phagocytosis
Vorselen, D.; Kamber, R. A.; Labitigan, R. L. D.; van Loon, A. P.; Peterman, E.; Delgado, M. K.; Lin, S.; Rasmussen, J. P.; Bassik, M. C.; Theriot, J. A.
10.1101/2022.07.30.502145 — cell biology — Posted on 2022-07-31
60 New motifs in Ndc1 mediating interaction with the Nup84 complex and nuclear membranes
Amm, I.; Weberruss, M.; Hellwig, A.; Schwarz, J.; Tatarek-Nossol, M.; Lüchtenborg, C.; Kallas, M.; Brügger, B.; Hurt, E.; Antonin, W.
10.1101/2022.07.31.501833 — cell biology — Posted on 2022-07-31
63 Unconstrained generation of synthetic antibody-antigen structures to guide machine learning methodology for real-world antibody specificity prediction
Robert, P. A.; Akbar, R.; Frank, R.; Pavlovic, M.; Widrich, M.; Snapkov, I.; Slabodkin, A.; Chernigovskaya, M.; Scheffer, L.; Smorodina, E.; Rawat, P.; Mehta, B. B.; Vu, M. H.; Froberg Mathisen, I.; Prosz, A.; Abram, K.; Olar, A.; Miho, E.; Haug, D. T. T.; Lund-Johansen, F.; Hochreiter, S.; Hobaek Haff, I.; Klambauer, G.; Sandve, G. K.; Greiff, V.
10.1101/2021.07.06.451258 — immunology — Posted on 2022-07-31
66 Microbial metabolite butyrate-prodrug polymeric micelles demonstrate therapeutic efficacy in pre-clinical models of food allergy and colitis
Wang, R.; Cao, S.; Bashir, M. E. H.; Hesser, L. A.; Su, Y.; Hong, S. M. C.; Thompson, A.; Culleen, E.; Sabados, M.; Dylla, N. P.; Campbell, E.; Bao, R.; Nonnecke, E. B.; Bevins, C. L.; Wilson, D. S.; Hubbell, J. A.; Nagler, C. R.
10.1101/2022.05.01.490224 — bioengineering — Posted on 2022-07-30
67 Unbiased identification of unknown cellular and environmental factors that mediate eQTLs using principal interaction component analysis
Vochteloo, M.; Deelen, P.; Vink, B.; BIOS Consortium, ; Tsai, E. A.; Runz, H.; Andreu-Sanchez, S.; Fu, J.; Zhernakova, A.; Westra, H.-J.; Franke, L.
10.1101/2022.07.28.501849 — genomics — Posted on 2022-07-30
68 ArpC5 isoforms regulate Arp2/3 complex-dependent protrusion through differential Ena/VASP positioning
Faessler, F.; Javoor, M.; Datler, J.; Doering, H.; Hofer, F.; Dimchev, G.; Hodirnau, V.-V.; Rottner, K.; Schur, F. K.
10.1101/2022.07.28.501813 — cell biology — Posted on 2022-07-30
69 Characterization, Comparison, and Optimization of Lattice Light Sheets
Ruan, X.; Liu, G.; Milkie, D. E.; Gorlitz, F.; Mueller, M.; Hercule, W.; Kililea, A.; Betzig, E.; Upadhyayula, S.
10.1101/2022.07.30.502108 — cell biology — Posted on 2022-07-30
70 PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates
Mathavarajah, S.; Vergunst, K. L.; Williams, S. K.; He, R.; Maliougina, M.; Habib, E. B.; Park, M.; Salsman, J.; Roy, S.; Braasch, I.; Roger, A. J.; Langelaan, D. N.; Dellaire, G.
10.1101/2022.07.29.501749 — molecular biology — Posted on 2022-07-30
71 Genetic Diversity, Population Structure and Parentage Analysis in Brazilian Grapevine Hybrids after Half a Century of Genetic Breeding
de Oliveira, G. L.; Niederauer, G. F.; de Oliveira, F. A.; Rodrigues, C. S.; Hernandes, J. L.; de Souza, A. P.; Moura, M. F.
10.1101/2022.07.30.502144 — molecular biology — Posted on 2022-07-30
73 Outbreak of Highly Pathogenic Avian Influenza H5N1 in New England Seals
Puryear, W.; Sawatzki, K.; Hill, N. J.; Foss, A. D.; Stone, J. J.; Doughty, L.; Walk, D.; Gilbert, K.; Murray, M.; Cox, E.; Patel, P.; Mertz, Z.; Ellis, S.; Taylor, J.; Fauquier, D.; Smith, A.; DiGiovanni, R. A.; van de Guchte, A.; Gonzalez-Reiche, A. S.; Khalil, Z.; van Bakel, H.; Torchetti, M. K.; Lenoch, J. B.; Lantz, K.; Runstadler, J. A.
10.1101/2022.07.29.501155 — molecular biology — Posted on 2022-07-30
76 Deficiencies of Runx3 and tissue-resident CD4+ intestinal epithelial lymphocytes link intestinal dysbiosis and inflammation in mouse and human spondyloarthropathy
Bhuyan, Z.; Maradana, M.; Rahman, M. A.; Mehdi, A.; Bergot, A.-S.; Simone, D.; Hanson, A.; Nel, H.; Mesa, J. G.; El Kurdi, M.; Kenna, T.; Leo, P.; Rehaume, L.; Brown, M.; Ciccia, F.; Thomas, R.
10.1101/2022.07.28.501834 — immunology — Posted on 2022-07-30
78 Beta human papillomavirus 8E6 promotes alternative end-joining
Hu, C.; Bugbee, T.; Palinski, R.; Akinyemi, I.; McIntosh, M. T.; MacCarthy, T.; Bhaduri-McIntosh, S.; Wallace, N.
10.1101/2022.07.29.501983 — cancer biology — Posted on 2022-07-30
79 Comprehensive analysis of the transcription factor REST regulatory networks in IDH-mutant and IDH-wild type glioma
Perycz, M.; Dabrowski, M. J.; Jardanowska, M.; Roura, A.-J.; Gielniewski, B.; Stepniak, K.; Draminski, M.; Kaminska, B.; Wojtas, B.
10.1101/2022.07.28.501927 — cancer biology — Posted on 2022-07-30
80 Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer
Fu, J.; Li, J.; Li, C.-F.; Tsai, C.-L.; Yin, W.; Hou, J.; Chen, P.; Cao, Y.; Kang, Y.; Sun, Y.; Xia, X.; Furukawa, K.; Lu, Y.; Wu, M.; Huang, Q.; Yao, J.; Hawke, D. H.; Pan, B.-F.; Zhao, J.; Huang, J.; Wang, H.; Bahassi, E. M.; Stambrook, P. J.; Huang, P.; Fleming, J. B.; Maitra, A. B.; Tainer, J.; Hung, M.-C.; Chiao, P.
10.1101/2022.07.28.501759 — cancer biology — Posted on 2022-07-30
84 Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs
Rathinaswamy, M. K.; Jenkins, M. L.; Zhang, X.; Stariha, J. T.; Ranga-Prasad, H.; Dalwadi, U.; Fleming, K. D.; Yip, C. K.; Williams, R. L.; Burke, J. E.
10.1101/2022.07.29.502076 — biochemistry — Posted on 2022-07-30
85 Solid-state enzymatic hydrolysis of mixed PET-cotton textiles
Kaabel, S.; Arciszewski, J.; Borchers, T. H.; Therien, J. P. D.; Friscic, T.; Auclair, K.
10.1101/2022.07.29.502078 — biochemistry — Posted on 2022-07-30
88 Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.
Elliff, J.; Biswas, A.; Kuppa, S.; Roshan, P.; Burd, R.; Chinnaraj, M.; Patterson, A.; Mattice, J.; Walker, S.; Pozzi, N.; Antony, E.; Bothner, B.; Origanti, S. S.
10.1101/2022.07.29.502049 — biochemistry — Posted on 2022-07-30
96 Interspecies Killing Activity of Pseudomonas syringae Tailocins
Weaver, S. L.; Zhu, L.; Ravishankar, S.; Clark, M.; Baltrus, D. A.
10.1101/2022.07.29.502058 — microbiology — Posted on 2022-07-30
98 LincRNA-Cox2 regulates smoke-induced inflammation in murine macrophages
Carpenter, S.; Salih, M. M.; Robinson, E. K.; Malekos, E.; Perez, E.; Capili, A.; Kim, K.; Zhang, W. Z.; Clonnan, S. M.
10.1101/2022.07.28.501765 — immunology — Posted on 2022-07-30
99 Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8
Farhat, D.; Rezaei, F.; Ristovski, M.; Yang, Y.; Stancescu, A.; Dzimkova, L.; Samnani, S.; Couture, J.-F.; Lee, J.-Y.
10.1101/2022.05.18.492512 — biochemistry — Posted on 2022-07-30
101 Glucose intolerance in aging is mediated by the Gpcpd1-GPC metabolic axis
Cikes, D.; Leutner, M.; Cronin, S. J. - F.; Novatchkova, M.; Pfleger, L.; Klepochova, R.; Rullman, E.; Gustafsson, T.; Hagelkrueys, A.; Knauf, C.; Moro, C.; Krebs, M.; Kautzky-Willer, A.; Krssak, M.; Orthofer, M.; Penninger, J. M.
10.1101/2021.10.26.465828 — physiology — Posted on 2022-07-30
102 Allosteric Inhibition of PTP1B by a Nonpolar Terpenoid
Friedman, A. J.; Liechty, E. T.; Kramer, L. D.; Sarkar, A.; Fox, J.; Shirts, M.
10.1101/2022.05.18.492571 — biochemistry — Posted on 2022-07-30
104 Yield Prediction Through Integration of Genetic, Environment, and Management Data Through Deep Learning
Kick, D.; Wallace, J.; Schnable, J. C.; Kolkman, J. M.; Alaca, B.; Beissinger, T. M.; Ertl, D.; Flint-Garcia, S.; Gage, J. L.; Hirsch, C. N.; Knoll, J. E.; de Leon, N.; Lima, D. C.; Moreta, D.; Singh, M.; Weldekidan, T.; Washburn, J. D.
10.1101/2022.07.29.502051 — plant biology — Posted on 2022-07-30
105 Identification of an A20 critical region harboring missense variations that lead to autoinflammation
El Khouri, E.; Louvrier, C.; Assrawi, E.; Nguyen, A.; Piterboth, W.; Deshayes, S.; Desdoits, A.; Copin, B.; Dastot Le Moal, F.; Karabina, S. A.; Amselem, S.; Aouba, A.; Giurgea, I.
10.1101/2022.07.29.502017 — genetics — Posted on 2022-07-30
106 Physiological traits and their relationships vary along an aridity gradient within and among Fijian bee species
da Silva, C. R. B.; Beaman, J. E.; Tuiwawa, M.; Stevens, M. I.; Gloag, R.; Kellermann, V.; Alton, L. A.
10.1101/2022.07.27.501487 — evolutionary biology — Posted on 2022-07-30
107 Horizontal transfer of bacteriocin biosynthesis genes requires metabolic adaptation to improve compound production and cellular fitness
Krauss, S.; Harbig, T. A.; Rapp, J.; Schäfle, T.; Franz-Wachtel, M.; Reetz, L.; Elsherbini, A. M. A.; Macek, B.; Grond, S.; Link, H.; Nieselt, K.; Krismer, B.; Peschel, A.; Heilbronner, S.
10.1101/2022.07.28.501952 — microbiology — Posted on 2022-07-30
108 Identification of Mycobacterium abscessus subspecies by MALDI-TOF Mass Spectrometry and Machine Learning
Rodriguez-Temporal, D.; Herrera-Leon, L.; Alcaide, F.; Domingo, D.; Vila-Olmo, N.; Arroyo, M. J.; Mendez, G.; Munoz, P.; Mancera, L.; Ruiz-Serrano, M. J.; Rodriguez-Sanchez, B.
10.1101/2022.07.28.501950 — microbiology — Posted on 2022-07-30
109 APA-Scan: Detection and Visualization of 3'-UTR APA with RNA-seq and 3'-end-seq Data
Fahmi, N. A.; Ahmed, K. T.; Chang, J.-W.; Nassereddeen, H.; Fan, D.; Yong, J.; Zhang, W.
10.1101/2020.02.16.951657 — bioinformatics — Posted on 2022-07-30
111 Establishing Physalis as a new Solanaceae model system enables genetic reevaluation of the inflated calyx syndrome
He, J.; Alonge, M.; Ramakrishnan, S.; Benoit, M.; Soyk, S.; Reem, N.; Hendelman, A.; Van Eck, J.; Schatz, M.; Lippman, Z.
10.1101/2022.07.29.502011 — plant biology — Posted on 2022-07-30
112 Pathogen effector-associated nuclear-localization of RPW8.2 amplifies its expression to boost immunity in Arabidopsis
Zhao, J.-h.; Huang, Y.; Wang, H.; Yang, X.-m.; Fan, J.; Li, Y.; Pu, M.; Zhou, S.-X.; Zhang, J.-W.; Zhao, Z.-x.; Li, G.-B.; Hassan, B.; Hu, X.-H.; Chen, X.; Xiao, S.; Wu, X.-J.; Wang, W.-M.
10.1101/2022.07.28.501905 — plant biology — Posted on 2022-07-30
113 miR167-ARF8, an auxin-responsive module involved in the formation of root-knot nematode-induced galls in tomato
Noureddine, Y.; da Rocha, M.; An, J.; Medina, C.; Mejias, J.; Quentin, M.; Abad, P.; Zouine, M.; Favery, B.; Jaubert, S.
10.1101/2022.07.29.501986 — plant biology — Posted on 2022-07-30
115 Extensive plant use of exometabolites
Hu, Y.; Andeer, P. F.; Zheng, Q.; Kosina, S. M.; Jardine, K. J.; Ding, Y.; Han, L. Z.; Gao, Y.; Zengler, K.; Bowen, B. P.; Mortimer, J. C.; Vogel, J. P.; Northen, T. R.
10.1101/2022.07.29.496484 — plant biology — Posted on 2022-07-30
118 ID1 functions as an autonomous phosphate (Pi) regulator upstream of the miR399-ZmPHO2 signaling module in maize
Wang, X.; Yuan, D.; Liu, Y.; Liang, Y.; He, J.; Yang, X.; Hang, R.; Jia, H.; Mo, B.; Tian, F.; Chen, X.; Liu, L.
10.1101/2022.07.29.502052 — plant biology — Posted on 2022-07-30
119 Evolution of the Growth Hormone Gene Duplication in Passerine Birds
Rasband, S. A.; Bolton, P. E.; Fang, Q.; Johnson, P. L. F.; Braun, M. J.
10.1101/2022.07.29.502092 — molecular biology — Posted on 2022-07-30
123 An Sfi1-like centrin-interacting centriolar plaque protein affects nuclear microtubule homeostasis.
Wenz, C.; Simon, C. S.; Romao, T. P.; Stuermer, V.; Machado, M.; Klages, N.; Klemmer, A.; Voss, Y.; Ganter, M.; Brochet, M.; Guizetti, J.
10.1101/2022.07.28.501831 — cell biology — Posted on 2022-07-29
124 Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening
Vanmechelen, B.; Stroobants, J.; Chiu, W.; Naesens, L.; Schepers, J.; Vermeire, K.; Maes, P.
10.1101/2022.07.29.502006 — microbiology — Posted on 2022-07-29
127 Microbiota colonization tunes the antigen threshold of microbiota-specific T cell activation in the gut
Hoces, D.; Corak, B.; Estrada Brull, A.; Berent, S.; Faccin, E.; Moresi, C.; Keys, T.; Joller, N.; Slack, E.
10.1101/2022.07.29.501979 — immunology — Posted on 2022-07-29
131 Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells
Donnelly, H.; Ross, E.; Xiao, Y.; Hermantara, R.; Taqi, A. F. J. M. A.; Cheng, Z. A.; Jain, N.; West, C. C.; Peault, B.; West, A. G.; Salmeron-Sanchez, M.; Dalby, M. J.
10.1101/2022.07.28.501818 — bioengineering — Posted on 2022-07-29
132 De novo assembly and annotation of the singing mouse genome
Smith, S. K.; Frazel, P. W.; Khodadadi-Jamayran, A.; Zappile, P.; Marier, C.; Okhovat, M.; Brown, S. M.; Long, M. A.; Heguy, A.; Phelps, S. M.
10.1101/2022.07.29.502048 — genomics — Posted on 2022-07-29
133 Improved Nanopore full-length cDNA sequencing by PCR-suppression
Bayega, A.; Oikonomopoulos, S.; Wang, Y. C.; Mathiopoulos, K.; Ragoussis, J.
10.1101/2022.07.28.501892 — genomics — Posted on 2022-07-29
138 Unexpected higher convergence of human-great ape enteric viromes in central African forest than in a European zoo: A One Health analysis
Narat, V.; Salmona, M.; Kampo, M.; Heyer, T.; Mercier-Delarue, S.; Ranger, N.; Rupp, S.; Ambata, P.; Njouom, R.; Simon, F.; Le Goff, J.; Giles-Vernick, T.
10.1101/2022.07.29.501976 — molecular biology — Posted on 2022-07-29
143 Discovery of an AIM2 inflammasome inhibitor for the treatment of DNA-driven inflammatory disease.
Green, J. P.; El-Sharkawy, L. Y.; Roth, S.; Zhu, J.; Cao, J.; Leach, A.; Liesz, A.; Freeman, S.; Brough, D.
10.1101/2022.07.28.501942 — immunology — Posted on 2022-07-29
147 OM-85 reduces SARS-COV-2 viral RNA expression in nasopharyngeal cells from COVID-19 patients
Cassao, G.; Antunes, K. H.; Goncalves, J. I. B.; Santos, L. D.; Abbadi, B. L.; Bizarro, C. V.; Machado, P.; Basso, L. A.; Pasquali, C.; Stein, R.; Souza, A. P. D. d.
10.1101/2022.07.29.502045 — microbiology — Posted on 2022-07-29
150 Infection- or vaccine mediated immunity reduces SARS-CoV-2 transmission, but increases competitiveness of Omicron in hamsters
Port, J. R.; Yinda, C. K.; Riopelle, J. C.; Weishampel, Z. A.; Saturday, T. A.; Avanzato, V. A.; Schukz, J. E.; Holbrook, M. G.; Barbian, K.; Perry-Gottschalk, R.; Haddock, E.; Martens, C.; Shaia, C. I.; Lambe, T.; Gilbert, S. C.; van Doremalen, N.; Munster, V. J.
10.1101/2022.07.29.502072 — microbiology — Posted on 2022-07-29
151 The porcine cGAS-STING pathway exerts an unusual antiviral function independent of IFN and autophagy
Zhu, J.; Jiang, S.; Xia, N.; Luo, J.; Zhang, Y.; Cao, Q.; Zhang, J.; Wang, Y.; Zheng, W.; Chen, N.; Meurens, F.
10.1101/2022.07.28.501948 — immunology — Posted on 2022-07-29
154 Hypothalamic extraretinal photoreceptor Opsin3 regulates water balance, body temperature and motor activity
Barez-Lopez, S.; Elsamad, G.; Bishop, P.; Searby, D.; Kershaw, Y.; Conway-Campbell, B.; Murphy, D.; Greenwood, M. P.
10.1101/2022.07.28.501815 — neuroscience — Posted on 2022-07-29
155 Loop stacking organizes genome folding from TADs to chromosomes
Hafner, A.; Park, M.; Berger, S. E.; Nora, E.; Boettiger, A. N.
10.1101/2022.07.13.499982 — biophysics — Posted on 2022-07-29
157 Allosteric Regulation of Aptamer Affinity through Mechano-Chemical Coupling
Qu, H.; Zheng, M.; Ma, Q.; Wang, L.; Mao, Y.; Eisenstein, M.; Soh, H. T.; Zheng, L.
10.1101/2022.07.28.501929 — biochemistry — Posted on 2022-07-29
161 MISPEL: A deep learning approach for harmonizingmulti-scanner matched neuroimaging data
Torbati, M. E.; Minhas, D. S.; Laymon, C. M.; Maillard, P.; Wilson, J. D.; Chen, C.-L.; Crainiceanu, C. M.; DeCarli, C. S.; Hwang, S. J.; Tudorascu, D. L.
10.1101/2022.07.27.501786 — neuroscience — Posted on 2022-07-29
162 A developmental atlas of the mouse brain by single-cell mass cytometry
Van Deusen, A. L.; Goggin, S. M.; Williams, C. M.; Keeler, A. B.; Fread, K. I.; Cheng, I.; Deppmann, C. D.; Zunder, E. R.
10.1101/2022.07.27.501794 — neuroscience — Posted on 2022-07-29
164 Data-driven discovery of canonical large-scale brain dynamics
Piccinini, J.; Deco, G.; Kringelbach, M. L.; Laufs, H.; Perl, Y. S.; Tagliazucchi, E.
10.1101/2022.07.27.501789 — neuroscience — Posted on 2022-07-29
165 Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation
Sivakumar, S.; Moore, J. A.; Montesion, M.; Sharaf, R.; Lin, D. I.; Fleischmann, Z.; Ebot, E. M.; Newberg, J.; Mills, J. M.; Hedge, P. S.; Frampton, G. M.; Sage, J.; Lovly, C. M.
10.1101/2022.07.27.501738 — cancer biology — Posted on 2022-07-29
166 Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice
Rashidieh, B.; Bain, A. L.; Tria, S. M.; Sharma, S.; Stewart, C. A.; Simmons, J. L.; Apaja, P. M.; Duijf, P. H. G.; Finnie, J.; Khanna, K. K.
10.1101/2022.07.27.501790 — cancer biology — Posted on 2022-07-29
167 SpatialSort: A Bayesian Model for Clustering and CellPopulation Annotation of Spatial Proteomics Data
Lee, E.; Chern, K.; Nissen, M.; Wang, X.; IMAXT Consortium, ; Huang, C.; Gandhi, A. K.; Bouchard-Cote, A.; Weng, A. P.; Roth, A.
10.1101/2022.07.27.499974 — bioinformatics — Posted on 2022-07-29
168 Revisiting the significance of keratin expression in complex epithelia
Cohen, E.; Johnson, C. N.; Redmond, C. J.; Nair, R. R.; Coulombe, P. A.
10.1101/2022.07.27.501769 — bioinformatics — Posted on 2022-07-29
173 Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II assembly and stability
Reynolds, M. B.; Hong, H. S.; Michmerhuizen, B. C.; Lawrence, A.-L. E.; Zhang, L.; Knight, J. S.; Lyssiotis, C. A.; Abuaita, B. H.; O'Riordan, M. X.
10.1101/2022.07.27.501734 — immunology — Posted on 2022-07-29
175 Decoding Depression During Subcallosal Cingulate Deep Brain Stimulation
Tiruvadi, V.; Veerakumar, A.; Smart, O.; Crowell, A.; Riva-Posse, P.; Gross, R. E.; McIntyre, C. C.; Rozell, C.; Butera, R.; Mayberg, H.
10.1101/2022.07.27.501778 — neuroscience — Posted on 2022-07-29
176 Computationally efficient framework for diagnosing, understanding, and predicting biphasic population growth
Murphy, R. J.; Maclaren, O. J.; Calabrese, A. R.; Thomas, P. B.; Warne, D. J.; Williams, E. D.; Simpson, M. J.
10.1101/2022.07.27.501797 — systems biology — Posted on 2022-07-29
180 BRAFV600E expression in thyrocytes causes recruitment of immunosuppressive STABILIN-1 macrophages
Spourquet, C.; Delcorte, O.; Lemoine, P.; Dauguet, N.; Loriot, A.; Achouri, Y.; Hollmen, M.; Jalkanen, S.; Huaux, F.; Lucas, S.; Van Meerbeeck, P.; Knauf, J.; Fagin, J. A.; Dessy, C.; Mourad, M.; Henriet, P.; Tyteca, D.; Marbaix, E.; Pierreux, C. E.
10.1101/2022.07.27.501733 — cancer biology — Posted on 2022-07-29
181 Combined SPT and FCS methods highlight a mechanism of RNAP II oversampling in cell nuclei
FOURNIER, M.; LECLERC, P.; LERAY, A.; CHAMPELOVIER, D.; AGBAZAHOU, F.; BIDAUX, G.; FURLAN, A.; HELIOT, L.
10.1101/2022.07.27.501703 — biophysics — Posted on 2022-07-29
186 Multiscale functional connectivity patterns of the aging brain learned from rsfMRI data of 4,259 individuals of the multi-cohort iSTAGING study
Zhou, Z.; Srinivasan, D.; Li, H.; Abdulkadir, A.; Nasrallah, I.; Wen, J.; Doshi, J.; Erus, G.; Mamourian, E.; Bryan, N. R.; Wolk, D. A.; Beason-Held, L.; Resnick, S. M.; Satterthwaite, T. D.; Davatzikos, C.; Shou, H.; Fan, Y.
10.1101/2022.07.27.501626 — bioengineering — Posted on 2022-07-29
188 Towards 3D-bioprinting of osseous tissue of pre-defined shape using single-matrix cell-bioink constructs
Gu, Y.; Pigeot, S.; Ahrens, L.; Tribukait-Riemenschneider, F.; Sarem, M.; Wolf, F.; Barbero, A.; Martin, I.; Shastri, P.
10.1101/2022.07.27.501781 — bioengineering — Posted on 2022-07-29
190 Chromatin accessibility profiling in tissue sections by spatial ATAC
Llorens-Bobadilla, E.; Zamboni, M.; Marklund, M.; Bhalla, N.; Chen, X.; Hartman, J.; Frisen, J.; Stahl, P. L.
10.1101/2022.07.27.500203 — genomics — Posted on 2022-07-29
192 Message in a Bottle: Archived DNA Reveals Marine Heatwave-Associated Shifts in Fish Assemblages
Gold, Z.; Kelly, R. P.; Shelton, A. O.; Thompson, A. R.; Goodwin, K. D.; Gallego, R.; Parsons, K. M.; Thompson, L. R.; Kacev, D.; Barber, P. H.
10.1101/2022.07.27.501788 — ecology — Posted on 2022-07-29
193 MEPSi: A tool for simulating tomograms of membrane-embedded proteins
Rodriguez de Francisco, B.; Bezault, A.; Xu, X.-P.; Hanein, D.; Volkmann, N.
10.1101/2022.07.27.501771 — cell biology — Posted on 2022-07-29
194 Retromer oligomerization drives SNX-BAR coat assembly and membrane constriction
Gopaldass, N.; De Leo, M. G. G.; Courtellement, T.; Mercier, V.; Bissig, C.; Roux, A.; Mayer, A.
10.1101/2022.07.27.501715 — cell biology — Posted on 2022-07-29
196 Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone
Zhong, L.; Lu, J.; Fang, J.; Yao, L.; Yu, W.; Gui, T.; Holdreith, N.; Bautista, C.; Choi, Y.; Jiang, J. X.; Yang, S.; Tong, W.; Dyment, N.; Qin, L.
10.1101/2022.07.27.501742 — cell biology — Posted on 2022-07-29
198 A translational approach to measuring the neural systems underlying approach-avoidance conflict in humans
Rolle, C. E.; Amemori, K.; Johnson, N.; Yan, M.; Caudle, T.; Havelka, A.; Gross, J. J.; Etkin, A.
10.1101/2022.07.27.501746 — neuroscience — Posted on 2022-07-29
200 TROP2 represents a negative prognostic factor in colorectal adenocarcinoma and its expression is associated with features of epithelial-mesenchymal transition and invasiveness
Svec, J.; Stastna, M.; Janeckova, L.; Hrckulak, D.; Vojtechova, M.; Onhajzer, J.; Kriz, V.; Galuskova, K.; Sloncova, E.; Kubovciak, J.; Pfeiferova, L.; Hrudka, J.; Matej, R.; Waldauf, P.; Havluj, L.; Kolar, M.; Korinek, V.
10.1101/2022.07.27.501720 — cancer biology — Posted on 2022-07-29
205 Possible Functional Proximity of Various Organisms Based on Taste Receptors Genomics
Hassan, S. S.; Sil, M.; Chakraborty, S.; Goswami, A.; Basu, P.; Nawn, D.; Uversky, V. N.
10.1101/2022.07.27.501642 — genomics — Posted on 2022-07-29
207 Biophysical ordering transitions underlie genome 3D re-organization during cricket spermiogenesis.
Orsi, G. A.; Tortora, M. M. C.; Horard, B.; Baas, D.; Kleman, J.-P.; Bucevicius, J.; Lukinavicius, G.; Jost, D.; Loppin, B.
10.1101/2022.07.27.501709 — cell biology — Posted on 2022-07-29
209 A multispecific antibody confers pan-reactive SARS-CoV-2 neutralization and prevents immune escape
Misasi, J.; Wei, R. R.; Wang, L.; Pegu, A.; Wei, C.-J.; Oloniniyi, O.; Zhou, T.; Zhao, B.; Choe, M.; Boruszczak, M.; Chen, M.; Leung, K.; Li, J.; Yang, E. S.; Yang, Z.-Y.; Zhang, Y.; Carlton, K.; Harris, D. R.; Ivleva, V. B.; Lei, P.; Liu, C.; Longobardi, L.; Olia, A. S.; Shi, W.; Wolff, J. J.; Gall, J.; Koup, R. A.; Kwong, P. D.; Mascola, J. R.; Nabel, G. J.; Sullivan, N. J.
10.1101/2022.07.29.502029 — immunology — Posted on 2022-07-29
210 Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
Gomolka, R. S.; Hablitz, L. M.; Mestre, H. P.; Gianetto, M.; Du, T.; Hauglund, N. L.; Xie, L.; Peng, W.; Martinez, P. M.; Nedergaard, M.; Mori, Y.
10.1101/2022.07.27.501409 — neuroscience — Posted on 2022-07-29
211 Functional integrity of visual coding following advanced photoreceptor degeneration
Rodgers, J.; Hughes, S.; Lindner, M.; Allen, A. E.; Ebrahimi, A.; Storchi, R.; Peirson, S. N.; Lucas, R. J.; Hankins, M. W.
10.1101/2022.07.27.501697 — neuroscience — Posted on 2022-07-29
212 Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data
Warchol, S.; Krueger, R.; Nirmal, A. J.; Gaglia, G.; Jessup, J.; Ritch, C. C.; Hoffer, J.; Muhlich, J. L.; Burger, M.; Jacks, T. L.; Santagata, S.; Sorger, P. K.; Pfister, H.
10.1101/2022.05.09.490039 — cell biology — Posted on 2022-07-29
214 A Human Liver Organoid Screening Platform for DILI Risk Prediction
Zhang, C. J.; Meyer, S. R.; O'Meara, M. J.; Huang, S.; Capeling, M. M.; Ferrer-Torres, D.; Childs, C. J.; Spence, J. R.; Fontana, R. J.; Sexton, J. Z.
10.1101/2021.08.26.457824 — pharmacology and toxicology — Posted on 2022-07-29
215 Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet
Viner, C.; Ishak, C. A.; Johnson, J.; Walker, N. J.; Shi, H.; Sjöberg-Herrera, M. K.; Shen, S. Y.; Lardo, S. M.; Adams, D. J.; Ferguson-Smith, A. C.; De Carvalho, D. D.; Hainer, S. J.; Bailey, T. L.; Hoffman, M. M.
10.1101/043794 — bioinformatics — Posted on 2022-07-29
216 miR-34c-3p ablation of PRKAR2B regulates PKA independent of cAMP in Theileria-transformed leukocytes
Haidar, M.; Tajeri, S.; Momeux, L.; Mourier, T.; mfarrej, s.; Benrached, F.; RCHIAD, Z.; Pain, A.; Langsley, G.
10.1101/2020.04.11.037341 — cell biology — Posted on 2022-07-29
220 Ultraliser: a framework for creating multiscale, high-fidelity and geometrically realistic 3D models for in silico neuroscience
Abdellah, M.; Garcia Cantero, J. J.; Roman Guerrero, N.; Foni, A.; Coggan, J. S.; Cali, C.; Agus, M.; Zisis, E.; Keller, D.; Hadwiger, M.; Magistretti, P.; Markram, H.; Schürmann, F.
10.1101/2022.07.27.501675 — bioinformatics — Posted on 2022-07-29
222 The macroevolutionary impact of recent and imminent mammal extinctions on Madagascar
Michielsen, N. M.; Goodman, S. M.; Soarimalala, V.; van der Geer, A.; Davalos, L.; Saville, G. I.; Upham, N.; Valente, L.
10.1101/2022.07.27.501413 — evolutionary biology — Posted on 2022-07-29
224 De-differentiation and Proliferation of Artery Endothelial Cells Drive Coronary Collateral Development
Arolkar, G.; K, S.; Wang, H.; Gonzalez, K. M.; Kumar, S.; Rios Coronado, P. E.; Woo, J. Y.; Red-Horse, K.; Das, S.
10.1101/2022.07.27.501689 — developmental biology — Posted on 2022-07-29
226 Endothelial Dnmt3a controls placenta vascularization and function to support fetal growth
Gehrs, S.; Jakab, M. V.; Gutjahr, E.; Gu, Z.; Weichenhan, D.; Mogler, C.; Schlesner, M.; Plass, C.; Augustin, H. G.; Schlereth, K.
10.1101/2022.07.28.501807 — developmental biology — Posted on 2022-07-29
227 Spatial consistency of cell growth direction during organ morphogenesis requires CELLULOSE-SYNTHASE INTERACTIVE1
Mollier, C.; Skrzydeł, J.; Borowska-Wykret, D.; Majda, M.; Dulski, M.; Fruleux, A.; Wrzalik, R.; Smith, R.; Moneger, F.; Kwiatkowska, D.; Boudaoud, A.
10.1101/2022.07.27.501687 — developmental biology — Posted on 2022-07-29
228 Metformin Suppresses SARS-CoV-2 in Cell Culture
Parthasarathy, H.; Tandel, D.; Siddiqui, A. H.; Harshan, K. H.
10.1101/2021.11.18.469078 — microbiology — Posted on 2022-07-29
232 Perinatal correlated retinal activity is required for the wiring of visual axons in non-image forming nuclei
Herrera, E.; Negueruela, S.; Morenilla-Palao, C.; Herrera, M.; Coca, Y.; Florez-Paz, D. M.; Lopez-Cascales, M. T.; Gomis, A.
10.1101/2022.07.27.501692 — neuroscience — Posted on 2022-07-29
233 Highly-multiplexed serology for non-human mammals
Schuettenberg, A.; Pina, A.; Metrailer, M.; Pelaez-Sanchez, R. G.; Agudelo-Florez, P.; Alvaro Lopez, J.; Ryle, L.; Monroy, F. P.; Altin, J. A.; Ladner, J. T.
10.1101/2022.05.24.493290 — immunology — Posted on 2022-07-29
234 Mesoscopic in vivo human T2* dataset acquired using quantitative MRI at 7 Tesla
Gulban, O. F.; Bollmann, S.; Huber, R.; Wagstyl, K.; Goebel, R.; Poser, B. A.; Kay, K.; Ivanov, D.
10.1101/2021.11.25.470023 — neuroscience — Posted on 2022-07-29
236 Cellular segregation in co-cultures driven by differential adhesion and contractility on distinct time scales
Skamrahl, M.; Schuenemann, J.; Mukenhirn, M.; Gottwald, J.; Ferle, M.; Ruebeling, A.; Honigmann, A.; Janshoff, A.
10.1101/2022.05.23.492966 — biophysics — Posted on 2022-07-29
237 transferGWAS: GWAS of images using deep transfer learning
Kirchler, M.; Konigorski, S.; Norden, M.; Meltendorf, C.; Kloft, M.; Schurmann, C.; Lippert, C.
10.1101/2021.10.22.465430 — genetics — Posted on 2022-07-29
239 Doxorubicin induces prolonged DNA damage signal in cells overexpressing DEK isoform-2.
Ozcelik, E.; Kalayci, A.; Celik, B.; Avci, A.; Akyol, H.; Kilic, I. B.; Guzel, T.; Cetin, M.; Tuzlakoglu Ozturk, M.; Caliskaner, Z. O.; Tombaz, M.; Yoleri, D.; Konu, O.; Kandilci, A.
10.1101/2022.06.03.494677 — cell biology — Posted on 2022-07-29
240 In the back of your mind: Cortical mapping of paraspinal afferent inputs
Cole, D. M.; Stämpfli, P.; Gandia, R.; Schibli, L.; Gantner, S.; Schuetz, P.; Meier, M. L.
10.1101/2021.12.19.473341 — neuroscience — Posted on 2022-07-29
244 Coherent multi-level network oscillations create neural filters to favor quiescence over navigation in Drosophila
Raccuglia, D.; Suarez-Grimalt, R.; Krumm, L.; Brodersen, C. B.; Ender, A.; Jagannathan, S. R.; Winter, Y.; Yvon-Durocher, G.; Kemptner, R.; Geiger, J. R.; Owald, D.
10.1101/2022.03.11.483976 — neuroscience — Posted on 2022-07-29
245 Dissecting the conformational complexity and flipping mechanism of a prokaryotic heme transporter
Wu, D.; Mehdipour, A. R.; Finke, F.; Goojani, H. G.; Groh, R. R.; Grund, T. N.; Reichhart, T. M.; Zimmermann, R.; Welsch, S.; Bald, D.; Shepherd, M.; Hummer, G.; Safarian, S.
10.1101/2022.04.07.487047 — microbiology — Posted on 2022-07-29
246 naRNA is a canonical neutrophil extracellular trap (NET) component and novel inflammation-amplifying composite DAMP
Bork, F.; Greve, C. L.; Youn, C.; Chen, S.; Wang, Y.; Nasri, M.; Focken, J.; Scheurer, J.; Engels, P.; Dubbelaar, M.; Hipp, K.; Schittek, B.; Bugl, S.; Loeffler, M. W.; Skokowa, J.; Archer, N. K.; Weber, A. N.
10.1101/2022.07.26.499571 — immunology — Posted on 2022-07-29
249 A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females
Boehm, A. C.; Friedrich, A. B.; Hunt, S.; Bandow, P.; Siju, K. P.; De Backer, J.-F.; Claussen, J.; Link, M.-H.; Hofmann, T. F.; Dawid, C.; Grunwald Kadow, I. C.
10.1101/2021.07.24.453623 — neuroscience — Posted on 2022-07-29
253 Benchmarking long-read RNA-sequencing analysis tools using in silico mixtures
Dong, X.; Du, M. R. M.; Gouil, Q.; Tian, L.; Baldoni, P. L.; Smyth, G. K.; Amarasinghe, S. L.; Law, C. W.; Ritchie, M. E.
10.1101/2022.07.22.501076 — bioinformatics — Posted on 2022-07-29
254 Subtilases turn on Pectin Methylesterase activity for a robust apoplastic immunity against pathogens
Coculo, D.; Del Corpo, D.; Martinez, M. O.; Vera, P.; Piro, G.; De Caroli, M.; Lionetti, V.
10.1101/2022.07.28.501549 — plant biology — Posted on 2022-07-28
255 Dynamic microtubules slow down during their shrinkage phase
Luchniak, A.; Kuo, Y.-W.; McGuinness, C.; Sutradhar, S.; Orbach, R.; Mahamdeh, M. S. S.; Howard, J.
10.1101/2022.07.27.501773 — biophysics — Posted on 2022-07-28
256 Identification of a TNF-TNFR-like system in malaria vectors (Anopheles stephensi) likely to influence Plasmodium resistance
Srinivasan, S.; Ghosh, C.; Das, S.; Thakare, A.; Singh, S.; Ganesh, A.; Mahawar, H.; Jaisimha, A.; Krishna, M.; Chattopadhyay, A.; Borah, R.; Singh, V.; M, S.; Kumar, N.; Kumar, S.; Swain, S.; Subramani, S.
10.1101/2022.07.28.501812 — genomics — Posted on 2022-07-28
257 CTCF, BEAF-32 and CP190 are not required for the initial establishment of TADs in early Drosophila embryos, but have locus specific roles
Cavalheiro, G. R.; Girardot, C.; Viales, R.; Feng, S.; Pollex, T.; Ngoc Cao, T. B.; Lacour, P.; Rabinowitz, A.; Furlong, E. E. M.
10.1101/2022.07.27.501678 — developmental biology — Posted on 2022-07-28
259 Antibody recognition of CD4-induced open HIV-1 Env trimers
Yang, Z.; Dam, K.-M. A.; Gershoni, J. M.; Zolla-Pazner, S.; Bjorkman, P. J.
10.1101/2022.07.27.501785 — immunology — Posted on 2022-07-28
265 Characterization of heterogeneity in nanodisc samples using Feret signatures
Vilela, F.; Bezault, A.; Rodrigues de Francisco, B.; Sauvanet, C.; Xu, X.-P.; Swift, M. F.; Yao, Y.; Marrasi, F. M.; Hanein, D.; Volkmann, N.
10.1101/2022.07.28.501900 — molecular biology — Posted on 2022-07-28
266 Targeting triple-negative breast cancer with β1-integrin binding aptamer
Pleiko, K.; Haugas, M.; Parfejevs, V.; Pantelejevs, T.; Parisini, E.; Teesalu, T.; Riekstina, U.
10.1101/2022.07.28.501822 — molecular biology — Posted on 2022-07-28
267 A unique peptide recognition mechanism by the human relaxin family peptide receptor 4 (RXFP4)
Chen, Y.; Zhou, Q.; Wang, J.; Xu, Y.; Wang, Y.; Yan, J.; Wang, Y.; Zhu, Q.; Zhao, F.; Li, C.; Chen, C.-W.; Cai, X.; Bathgate, R. A. D.; Shen, C.; Xu, H. E.; Yang, D.; Liu, H.; Wang, M.-W.
10.1101/2022.07.28.501832 — molecular biology — Posted on 2022-07-28
268 Chaperone-Directed Ribosome Repair after Oxidative Damage
Yang, Y.-M.; Jung, Y.; Abegg, D.; Adibekian, A.; Carroll, K. S.; Karbstein, K.
10.1101/2022.07.28.501866 — molecular biology — Posted on 2022-07-28
269 Characterization of the NSE6 subunit of the Physcomitrium patens PpSMC5/6 complex
Lelkes, E.; Hola, M.; Jemelkova, J.; Stefanovie, B.; Kolesar, P.; Vagnerova, R.; Adamus, M.; Angelis, K. J.; Palecek, J. J.
10.1101/2022.07.28.501545 — molecular biology — Posted on 2022-07-28
273 Functional characterization of the RNA interference pathway in A. fumigatus reveals its potential for antifungal therapy
Kelani, A. A.; Bruch, A.; Rivieccio, F.; Visser, C.; Krueger, T.; Kniemeyer, O.; Bromley, M. J.; Bowyer, P.; Barber, A. E.; Brakhage, A. A.; Blango, M. G.
10.1101/2022.07.28.501871 — microbiology — Posted on 2022-07-28
276 Assembly mechanism and cryoEM structure of RecA recombination nucleofilaments from Streptococcus pneumoniae.
Hertzog, M.; Perry, T. N.; Dupaigne, P.; Serres, S.; Morales, V.; Soulet, A.-L.; Bell, J.; Margeat, E.; Kowalczykowski, S. C.; Le Cam, E.; Fronzes, R.; Polard, P.
10.1101/2022.07.28.501814 — microbiology — Posted on 2022-07-28
278 iPHoP: an integrated machine-learning framework to maximize host prediction for metagenome-assembled virus genomes
Roux, S.; Camargo, A. P.; Coutinho, F. H.; Dabdoub, S. M.; Dutilh, B. E.; Nayfach, S.; Tritt, A.
10.1101/2022.07.28.501908 — microbiology — Posted on 2022-07-28
280 A gene expression control technology for cell-free systems and synthetic cells via targeted gene silencing and transfection
Sato, W.; Rasmussen, M.; Gaut, N. J.; Devarajan, M.; Stokes, K.; Deich, C.; Engelhart, A. E.; Adamala, K. P.
10.1101/2022.07.28.501919 — synthetic biology — Posted on 2022-07-28
282 APC and P53 mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer
Tian, Y.; Wang, X.; Cramer, Z.; Rhoades, J.; Estep, K. N.; Ma, X.; Tzivelekidis, S. A.; Katona, B. W.; Johnson, F. B.; Yu, Z.; Blanco, M. A.; Lengner, C.; Li, N.
10.1101/2022.07.26.501557 — cancer biology — Posted on 2022-07-28
284 The Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States
Montgomery, K. M.; Carroll, E.; Thwin, A.; Hodges, P.; Southworth, D. R.; Gestwicki, J. E.
10.1101/2022.07.28.501920 — biochemistry — Posted on 2022-07-28
285 Mutational analysis of a conserved positive charge in the c-ring of E. coli ATP synthase
Shrestha, R. K.; Founds, M. W.; Shepard, S. J.; Rothrock, M. M.; Defnet, A. E.; Steed, R.
10.1101/2022.07.28.501891 — biochemistry — Posted on 2022-07-28
286 Allosteric Regulation of Aptamer Affinity through Mechano-Chemical Coupling
Qu, H.; Zheng, M.; Ma, Q.; Wang, L.; Mao, Y.; Eisenstein, M.; Soh, H. T.; Zheng, L.
10.1101/2022.07.28.501929 — biochemistry — Posted on 2022-07-28
290 Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain
Chen, Y.; Prevost, J.; Ullah, I.; Romero, H.; Lisi, V.; Tolbert, W. D.; Grover, J. R.; Ding, S.; Gong, S. Y.; Beaudoin-Bussieres, G.; Gasser, R.; Benlarbi, M.; Vezina, D.; Anand, S. P.; Chatterjee, D.; Goyette, G.; Grunst, M. W.; Yang, Z.; Bo, Y.; Zhou, F.; Beland, K.; Bai, X.; Zeher, A. R.; Huang, R. K.; Nguyen, D. N.; Sherburn, R.; Wu, D.; Piszczek, G.; Pare, B.; Matthies, D.; Xia, D.; Richard, J.; Kumar, P.; Mothes, W.; Cote, M.; Uchil, P. D.; Lavallee, V.-P.; Smith, M. A.; Pazgier, M.; Haddad, E.; Finzi, A.
10.1101/2022.07.27.501708 — microbiology — Posted on 2022-07-28
291 Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 Variants
Liao, S.; He, Y.; Qu, J.; Shi, Y.; Liu, Y.; Zhao, K.; Chen, J.; Jing, Y.; Shen, C. K.-F.; Ji, C.; Luo, G.; Zhao, X.; Li, S.; Fan, Y.; Lv, Z.; Fang, S.; He, Y.; Wu, C.; Zhang, R.; Zou, X.; Wang, P.; Li, L.
10.1101/2022.07.27.501719 — immunology — Posted on 2022-07-28
292 Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE
Borges, F. d. S.; Moreira, J. V. S.; Takarabe, L. M.; Lytton, W. W.; Dura-Bernal, S.
10.1101/2022.02.03.479029 — neuroscience — Posted on 2022-07-28
293 Comparing visual cortex of children and adults reveals a late-stage change in the architecture of V1
Himmelberg, M. M.; Tüncok, E.; Gomez, J.; Grill-Spector, K.; Carrasco, M.; Winawer, J.
10.1101/2022.07.22.501118 — neuroscience — Posted on 2022-07-28
296 Structural basis of organic cation transporter-3 inhibition
Khanppnavar, B.; Maier, J.; Herborg, F.; Gradisch, R.; Lazzarin, E.; Luethi, D.; Yang, J.-W.; Qi, C.; Holy, M.; Jaentsch, K.; Kudlacek, O.; Schicker, K.; Werge, T.; Gether, U.; Stockner, T.; Korkhov, V.; Sitte, H. H.
10.1101/2022.07.14.499921 — pharmacology and toxicology — Posted on 2022-07-28
298 Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini
Chaiyadet, S.; Tangkawattana, S.; Smout, M. J.; Ittiprasert, W.; Mann, V. H.; Deenonpoe, R.; Arunsan, P.; Loukas, A.; Brindley, P. J.; Laha, T.
10.1101/2021.12.10.472085 — cancer biology — Posted on 2022-07-28
304 Precise control of neural activity using temporally dithered and spatially multiplexed electrical stimulation
Shah, N. P.; Madugula, S.; Philips, A.; Grosberg, L. E.; Gogliettino, A. R.; Dusi, A.; Tandon, P.; Brown, J.; Hottowy, P.; Dabrowski, W.; Sher, A.; Litke, A.; Mitra, S.; Chichilnisky, E. J.
10.1101/2022.07.26.501643 — neuroscience — Posted on 2022-07-28
305 Functional imaging and quantification of multi-neuronal olfactory responses in C. elegans
Lin, A.; Qin, S.; Casademunt, H.; Wu, M.; Hung, W.; Cain, G.; Tan, N.; Valenzuela, R.; Lesanpezeshki, L.; Venkatachalam, V.; Pehlevan, C.; Zhen, M.; Samuel, A.
10.1101/2022.05.27.493772 — neuroscience — Posted on 2022-07-28
309 Transcriptomic classification of pituitary neuroendocrine tumors causing acromegaly
Rymuza, J.; Kober, P.; Rusetska, N.; Mossakowska, B. J.; Maksymowicz, M.; Nyc, A.; Baluszek, S.; Zielinski, G.; Kunicki, J.; Bujko, M.
10.1101/2022.07.26.501638 — cancer biology — Posted on 2022-07-28
311 Proteins with multiple G protein-coupled receptor domains
Isildayancan, K.; Kessel, A.; Solan, R.; Kolodny, R.; Ben-Tal, N.
10.1101/2022.07.26.501653 — bioinformatics — Posted on 2022-07-28
314 Dynamic states of cervical epithelia during pregnancy and epithelial barrier disruption
Cooley, A.; Madhukaran, S.; Stroebele, E.; Caraballo, M. C.; Wang, L.; Hon, G.; Mahendroo, M.
10.1101/2022.07.26.501609 — cell biology — Posted on 2022-07-28
317 Individual differences in oxycodone addiction-like behaviors in a large cohort of heterogeneous stock (HS) rats
Kallupi, M.; de Guglielmo, G.; Carrette, L. L.; Simpson, S.; Kononoff, J.; Kimbrough, A.; Smith, L. C.; Shankar, K.; Avelar, A.; Conlisk, D.; Brennan, M.; Tieu, L.; Sedighim, S.; Boomhower, B.; Maturin, L.; Fannon, M. J.; Martinez, A.; Crook, C.; Dirik, S.; Velarde, N.; Schweitzer, P.; Bonnet-Zahedi, S.; Othman, D. N.; Sichel, B.; Guess, K.; Peng, B.; Hu, A. S.; Chun, L. E.; Milan, K.; Lau, J.; Zheng, Y.; Vang, A.; Woods, L. C. S.; Palmer, A. A.; George, O.
10.1101/2022.07.26.501618 — neuroscience — Posted on 2022-07-28
318 The role of division stochasticity on the robustness of bacterial size dynamics
Nieto, C.; Arias-Castro, J. C.; Sanchez, C.; Vargas-Garcia, C.; Singh, A.; Pedraza, J. M.
10.1101/2022.07.27.501776 — systems biology — Posted on 2022-07-28
322 Maf Family Transcription Factors are Required for Nutrient Uptake in the Neonatal Gut
Bara, A. M.; Chen, L.; Ma, C.; Underwood, J.; Moreci, R. S.; Sumigray, K.; Sun, T.; Diao, Y.; Verzi, M.; Lechler, T.
10.1101/2022.07.26.501624 — physiology — Posted on 2022-07-28
323 ADOLESCENT EXPOSURE TO LOW-DOSE THC DISRUPTS ENERGY BALANCE AND ADIPOSE ORGAN HOMEOSTASIS IN ADULTHOOD
Lin, L.; Jung, K.-M.; Le, J.; Colleluori, G.; Wood, C.; Lee, H.-L.; Palese, F.; Squire, E.; Su, S.; Torrens, A.; Fotio, Y.; Tang, L.; Yu, C.; Yang, Q.; Huang, L.; DiPatrizio, N.; Jang, C.; Cinti, S.; Piomelli, D.
10.1101/2022.07.26.501615 — pharmacology and toxicology — Posted on 2022-07-28
325 Tumor landscape of epithelial ovarian cancer highlights that EGR1 drives tumor invasion at single-cell resolution
Guo, Q.; Zhang, Y.; Sun, S.; Qi, Y.; Dai, Y.; Hao, Y.; Xin, M.; Xu, R.; Chen, H.; Wu, X.; Liu, Q.; Kong, C.; Zhang, G.; Wang, P.
10.1101/2022.07.26.501637 — bioinformatics — Posted on 2022-07-28
327 zFACE: Facial Analytics from a Coordinate Extrapolation System for Developing Zebrafish
Maili, L.; Ruiz, O. E.; Kahan, P.; Larson, S. T.; Hashmi, S. S.; Hecht, J. T.; Eisenhoffer, G. T.
10.1101/2022.07.26.501188 — developmental biology — Posted on 2022-07-28
329 Age-related seroprevalence trajectories of seasonal coronaviruses in children
Luo, Y.; Lv, H.; Zhao, S.; Sun, Y.; Liu, C.; Chen, C.; Liang, W.; Kwok, K.-o.; Teo, Q. W.; So, R. T.; Lin, Y.; Deng, Y.; Li, B.; Dai, Z.; Zhu, J.; Zhang, D.; Fernando, J.; Wu, N. C.; Tun, H. M.; Bruzzone, R.; Mok, C. K.; Mu, X.
10.1101/2022.07.26.501649 — immunology — Posted on 2022-07-28
330 Accurate sex prediction of cisgender and transgender individuals without brain size bias
Wiersch, L.; Hamdan, S.; Hoffstaedter, F.; Votinov, M.; Habel, U.; Clemens, B.; Derntl, B.; Eickhoff, S. B.; Patil, K. R.; Weis, S.
10.1101/2022.07.26.499576 — neuroscience — Posted on 2022-07-28
332 Brain structural covariances in the ageing brain in the UK Biobank
Dong, C.; Thalamuthu, A.; Jiang, J.; Mather, K. A.; Sachdev, P. S.; Wen, W.
10.1101/2022.07.26.501635 — neuroscience — Posted on 2022-07-28
333 Genetic and environmental circadian disruption induce metabolic impairment through changes in the gut microbiome
Altaha, B.; Heddes, M.; Pilorz, V.; Niu, Y.; Gorbunova, E.; Gigl, M.; Kleigrewe, K.; Oster, H.; Haller, D.; Kiessling, S.
10.1101/2022.07.27.501612 — physiology — Posted on 2022-07-28
334 Strain stiffening of Ndc80 complexes attached to microtubule plus ends
Schwietert, F.; Volkov, V. A.; Huis in 't Veld, P. J.; Dogterom, M.; Musacchio, A.; Kierfeld, J.
10.1101/2022.03.15.484438 — biophysics — Posted on 2022-07-28
336 The efficacy of antiseptic agents against staphylococcal biofilm can be quantitatively assessed with the use of processed microscopic images
Junka, A. F.; Krasowski, G.; Migdal, P.; Woroszylo, M.; Fijalkowski, K.; Chodaczek, G.; Czajkowska, J.; Dudek, B.; Nowicka, J.; Oleksy, M.; Kwiek, B.; Paleczny, J.; Brozyna, M.
10.1101/2021.11.30.470646 — microbiology — Posted on 2022-07-28
337 Tumour mutations in long noncoding RNAs enhance cell fitness
Esposito, R.; Lanzos, A.; Polidori, T.; Guillen-Ramirez, H.; Merlin, B.; Mela, L.; Zoni, E.; Buechi, I.; Hovhannisyan, L.; McCluggage, F.; Medo, M.; Basile, G.; Meise, D. F.; Ramnarayanan, S.; Zwyssig, S.; Wenger, C.; Schwarz, K.; Vancura, A.; Bosch-Guiteras, N.; JuliKruithof-de Julio, M.; Zimmer, Y.; Medova, M.; Stroka, D.; Fox, A.; Johnson, R.
10.1101/2021.11.06.467555 — genomics — Posted on 2022-07-28
338 Novel leaf-root coordination driven by leaf water storage tissues in mangroves
Cao, J.; Yang, Q.; Chen, J.; Lu, M.; Ren, W.; Xiong, Y.; Pei, Y.; Kong, D.
10.1101/2022.07.26.501578 — ecology — Posted on 2022-07-28
339 Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice
Herriges, M.; Yampolskaya, M.; Thapa, B. R.; Lindstrom-Vautrin, J.; Wang, F.; Na, C.-L.; Ma, L.; Montminy, M. M.; Huang, J.; Villacorta-Martin, C.; Mehta, P.; Kotton, D. N.
10.1101/2022.07.26.501591 — cell biology — Posted on 2022-07-28
340 Integrated Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of Acute Graft-versus-Host-Disease
Lohmeyer, J. K.; Hirai, T.; Turkoz, M.; Buhler, S.; Ramos, T. L.; Koehler, N.; Baker, J.; Ji, X.; Villard, J.; Chalandon, Y.; Simonetta, F.; Negrin, R. S.
10.1101/2022.07.26.501553 — immunology — Posted on 2022-07-28
342 Acculturative orientations among Hispanic/Latinx caregivers in the ABCD Study: Associations with caregiver and youth mental health and youth brain function
Meca, A.; Peraza, J. A.; Riedel, M. C.; Musser, E. D.; Salo, T.; Flannery, J. S.; Bottenhorn, K. L.; Dick, A. S.; Pintos Lobo, R.; Ucros, L. M.; Greaves, C. A.; Hawes, S. W.; Sanchez, M.; Gonzalez, M. R.; Sutherland, M. T.; Gonzalez, R.; Laird, A. R.
10.1101/2022.07.24.501248 — neuroscience — Posted on 2022-07-28
344 System-level high-amplitude co-fluctuations
Betzel, R.; Chumin, E. J.; Zamani Esfahlani, F.; Tanner, J.; Faskowitz, J.
10.1101/2022.07.26.501262 — neuroscience — Posted on 2022-07-28
345 Distinct chaperonopathy in skeletal muscle associated with the dominant variant in DNAJB4
Inoue, M.; Noguchi, S.; Inoue, Y. U.; Iida, A.; Ogawa, M.; Bengoechea, R.; Pittman, S. K.; Hayashi, S.; Watanabe, K.; Hosoi, Y.; Sano, T.; Takao, M.; Oya, Y.; Takahashi, Y.; Miyajima, H.; Weihl, C. C.; Inoue, T.; Nishino, I.
10.1101/2022.07.26.501446 — neuroscience — Posted on 2022-07-28
349 Using transfer learning and dimensionality reduction techniques to improve generalisability of machine-learning predictions of mosquito ages from mid-infrared spectra
Mwanga, E. P.; Siria, D. J.; Mitton, J.; Mshani, I. H.; Jimenez, M. G.; Selvaraj, P.; Wynne, K.; Baldini, F.; Okumu, F. O.; Babayan, S. A.
10.1101/2022.07.26.501594 — bioinformatics — Posted on 2022-07-28
354 CRI-SPA, a mating based CRISPR-Cas9 assisted method for high-throughput genetic modification of yeast strain libraries
Olsson, H.; Cachera, P.; Coumou, H.; Jensen, M. L.; Sanchez, B. J.; Strucko, T.; van den Broek, M.; Daran, J.-M.; Jensen, M. K.; Sonnenschein, N.; Lisby, M.; Mortensen, U. H.
10.1101/2022.07.19.500587 — systems biology — Posted on 2022-07-28
356 Rethinking the nature of intraspecific variability and its consequences on species coexistence
Girard-Tercieux, C.; Marechaux, I.; Clark, A. T.; Clark, J. S.; Courbaud, B.; Fortunel, C.; Guillemot, J.; Kunstler, G.; le Maire, G.; Pelissier, R.; Rueger, N.; Vieilledent, G.
10.1101/2022.03.16.484259 — ecology — Posted on 2022-07-28
361 Honey Bees Get Map Coordinates from the Dance
Wang, Z.; Chen, X.; Becker, F.; Walter, S.; Greggers, U.; Werner, M.; Gallistel, C. R.; Menzel, R.
10.1101/2022.07.27.501756 — animal behavior and cognition — Posted on 2022-07-28
363 Single cell transcriptomics of human skin equivalent organoids
Stabell, A.; Wang, S.; Lee, G.; Ling, J.; Nguyen, S.; Sen, G.; Nie, Q.; Atwood, S.
10.1101/2022.07.27.501753 — systems biology — Posted on 2022-07-28
364 Glucose intolerance in aging is mediated by the Gpcpd1-GPC metabolic axis
Cikes, D.; Leutner, M.; Cronin, S. J. - F.; Novatchkova, M.; Pfleger, L.; Klepochova, R.; Rullman, E.; Gustafsson, T.; Hagelkrueys, A.; Knauf, C.; Moro, C.; Krebs, M.; Kautzky-Willer, A.; Krssak, M.; Orthofer, M.; Penninger, J. M.
10.1101/2021.10.26.465828 — physiology — Posted on 2022-07-28
365 Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2
Gahbauer, S.; Correy, G. J.; Schuller, M.; Ferla, M. P.; Doruk, Y. U.; Rachman, M.; Wu, T.; Diolaiti, M.; Wang, S.; Neitz, J.; Fearon, D.; Radchenko, D. S.; Moroz, Y.; Irwin, J. J.; Renslo, A. R.; Taylor, J. C.; Gestwicki, J. E.; von Delft, F.; Ashworth, A.; Ahel, I.; Shoichet, B. K.; Fraser, J. S.
10.1101/2022.06.27.497816 — biophysics — Posted on 2022-07-28
372 Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs
Yildiz, E.; El Alam, G.; Perino, A.; Jalil, A.; Denechaud, P.-D.; Huber, K.; Fajas, L.; Auwerx, J.; Sorrentino, G.; Schoonjans, K.
10.1101/2022.07.26.501569 — cell biology — Posted on 2022-07-28
373 Glucose lowering effects by sago (Metroxylon sagu Rottb) resistant starches Type 2 and 4 in spontaneously type 2 diabetes, Goto kakizaki rat
Lokman, E. F.; Bugam, S. H.; Ibrahim, A. S.; Yunus, N.; Mansor, F.; Balasubramaniam, V.; Lazim, R. M.; Seruji, A. Z. R. A.; Mohamad, K. M.
10.1101/2022.07.26.501535 — molecular biology — Posted on 2022-07-28
374 Polycomb repression during S/G2 phases restrain initiation of cell differentiation to the G1 phase of the cell cycle
Asenjo, H. G.; Alcazar-Fabra, M.; Espinosa, M.; Lopez-Onieva, L.; Gallardo, A.; Dimitrova, E.; Feldmann, A.; Pachano, T.; Martorell-Marugan, J.; Carmona-Saez, P.; Sanchez-Pozo, A.; Rada-Iglesias, A.; Klose, R. J.; Landeira, D.
10.1101/2022.07.26.501502 — molecular biology — Posted on 2022-07-28
376 Plants release miRNAs in the rhizosphere, targeting microbial genes
Middleton, H.; Monard, C.; Daburon, V.; Clostres, E.; Tremblay, J.; Yergeau, E.; El-Amrani, A.
10.1101/2022.07.26.501597 — plant biology — Posted on 2022-07-28
379 Critical role of PCYT2 in muscle health and aging
Cikes, D.; Elsayad, K.; Sezgin, E.; Koitai, E.; Ferenc, T.; Orthofer, M.; Yarwood, R.; Heinz, L.; Sedlyarov, V.; Darwish-Miranda, N.; Taylor, A.; Grapentine, S.; al-Murshedi, F.; Abot, A.; Weidinger, A.; Kutchukian, C.; Sanchez, C.; Cronin, S. J. F.; Novatchkova, M.; Kavirayani, A.; Schuetz, T.; Haubner, B.; Haas, L.; Hagelkrueys, A.; Jackowski, S.; Kozlov, A.; Jacquemond, V.; Knauf, C.; Superti-Furga, G.; Rullman, E.; Gustafsson, T.; McDermott, J. H.; Lowe, M. P.; Radak, Z.; Chamberlain, J. S.; Bakovic, M.; Banka, S.; Penninger, J.
10.1101/2022.03.02.482658 — genetics — Posted on 2022-07-28
380 Global signal topography in the human brain differs systematically across the lifespan
Nomi, J.; Bzdok, D.; Li, J.; Bolt, T.; Kornfeld, S.; Goodman, Z.; Yeo, B. T. T.; Spreng, R. N.; Uddin, L.
10.1101/2022.07.27.501804 — neuroscience — Posted on 2022-07-27
383 Arc Regulates a "Second-Guessing" Cognitive Bias During Naturalistic Foraging
Ravens, A.; Stacher-Hörndli, C. N.; Steinwand, S.; Shepherd, J. D.; Gregg, C.
10.1101/2022.07.27.501779 — neuroscience — Posted on 2022-07-27
387 RET enhancer haplotype-dependent remodeling of the human fetal gut development program
Chatterjee, S.; Fries, L. E.; Yaacov, O.; Hu, N.; Berk-Rauch, H. E.; Chakravarti, A.
10.1101/2022.07.26.501565 — genetics — Posted on 2022-07-27
388 Interdependent progression of bidirectional sister replisomes in E. coli
Chen, P. J.; McMullin, A. B.; Visser, B. J.; Mei, Q.; Rosenberg, S. M.; Bates, D. B.
10.1101/2022.07.27.501747 — genetics — Posted on 2022-07-27
391 naRNA is a canonical neutrophil extracellular trap (NET) component and novel inflammation-amplifying composite DAMP
Bork, F.; Greve, C. L.; Youn, C.; Chen, S.; Wang, Y.; Nasri, M.; Focken, J.; Scheurer, J.; Engels, P.; Dubbelaar, M.; Hipp, K.; Schittek, B.; Bugl, S.; Loeffler, M. W.; Skokowa, J.; Archer, N. E.; Weber, A. N.
10.1101/2022.07.26.499571 — immunology — Posted on 2022-07-27
392 Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies
Blaeschke, F.; Chen, Y. Y.; Apathy, R.; Li, Z.; Mowery, C. T.; Nyberg, W. A.; To, A.; Yu, R.; Bueno, R.; Kim, M. C.; Schmidt, R.; Goodman, D. B.; Feuchtinger, T.; Eyquem, J.; Ye, C. J.; Shifrut, E.; Roth, T. L.; Marson, A.
10.1101/2022.07.27.501186 — immunology — Posted on 2022-07-27
396 Segmented MS/MS acquisition of a1 ion-based strategy for in-depth proteome quantitation
Wang, Z.; Liu, C.; Wang, S.; Hou, X.; Gong, P.; Li, X.; Liang, Z.; Liu, J.; Zhang, L.; Zhang, Y.
10.1101/2022.07.27.501662 — biochemistry — Posted on 2022-07-27
399 Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of Drosophila testes
Raz, A. A.; Vida, G. S.; Stern, S. R.; Mahadevaraju, S.; Fingerhut, J. M.; Viveiros, J. M.; Pal, S.; Grey, J. R.; Grace, M. R.; Berry, C. W.; Li, H.; Janssens, J.; Saelens, W.; Shao, Z.; Hun, C.; Yamashita, Y. M.; Przytycka, T. M.; Oliver, B.; Brill, J. A.; Krause, H. M.; Matunis, E. L.; White-Cooper, H.; DiNardo, S.; Fuller, M. T.
10.1101/2022.07.26.501581 — developmental biology — Posted on 2022-07-27
403 Identification and full genome analysis of the first putative virus of sea buckthorn (Hippophae rhamnoides L.)
Balke, I.; Zeltina, V.; Zrelovs, N.; Kalnciema, I.; Resevica, G.; Ludviga, R.; Jansons, J.; Morocko-Bicevska, I.; Seglina, D. S.; Zeltins, A.
10.1101/2022.07.27.501707 — molecular biology — Posted on 2022-07-27
409 Bacterial cell widening alters periplasmic size and activates envelope stress responses
Zietek, M.; Miguel, A.; Khusainov, I.; Shi, H.; Asmar, A. T.; Ram, S.; Wartel, M.; Sueki, A.; Schorb, M.; Goulian, M.; Collet, J.-F.; Beck, M.; Huang, K. C.; Typas, A.
10.1101/2022.07.26.501644 — microbiology — Posted on 2022-07-27
414 Modulation of bacterial cell size and growth rate via activation of a cell envelope stress response
Miguel, A.; Zietek, M.; Shi, H.; Sueki, A.; Maier, L.; Verheul, J.; den Blaauwen, T.; Van Valen, D. A.; Typas, A.; Huang, K. C.
10.1101/2022.07.26.501648 — microbiology — Posted on 2022-07-27
415 Replication origin mapping in the malaria parasite Plasmodium falciparum
Totanes, F. I. G.; Gockel, J.; Chapman, S. E.; Bartfai, R.; Boemo, M. A.; Merrick, C. J.
10.1101/2022.07.27.501677 — microbiology — Posted on 2022-07-27
416 On the reproductive mechanisms of protocells
Kanaparthi, D.; Lampe, M.; Krohn, J. H.; Hildebrand, F.; Boesen, T.; Klingl, A.; Phapale, P.; Lueders, T.
10.1101/2021.11.25.470039 — biophysics — Posted on 2022-07-27
418 Human Milk Oligosaccharide 2'-fucosyllactose inhibits ligand binding to C-type lectin DC-SIGN but not to Langerin
Mukherjee, R.; Somovilla, V. J.; Chiodo, F.; Bruijns, S.; Pieters, R. J.; Garssen, J.; van Kooyk, Y.; BERGENHENEGOUWEN, J. v.; Kraneveld, A.
10.1101/2022.07.27.501236 — biochemistry — Posted on 2022-07-27
422 Honokiol inhibits SARS-CoV-2 replication in cell culture
Salgado-Benvindo, C.; Leijs, A. A.; Thaler, M.; Tas, A.; Arbiser, J. L.; Snijder, E. J.; van Hemert, M. J.
10.1101/2022.07.26.501656 — microbiology — Posted on 2022-07-27
429 De novo mutation and identity-by-descent drive disease haplotypes, biallelic traits and multilocus pathogenic variation
Coban Akdemir, Z.; Song, X.; Ceballos, F. C.; Pehlivan, D.; Karaca, E.; Bayram, Y.; Mitani, T.; Gambin, T. L.; Jhangiani, S.; muzny, d. m.; Lewis, R.; Baylor Hopkins Center for Mendelian Genomics, ; Liu, P.; Boerwinkle, E.; Hamosh, A.; Gibbs, R. A.; Sutton, R.; Sobreira, N.; Carvalho, C. M. B.; Shaw, C. A.; Posey, J.; Valle, D.; Lupski, J. R.
10.1101/2020.04.27.064824 — genomics — Posted on 2022-07-27
430 Ether Lipid Biosynthesis Promotes Lifespan Extension and Enables Diverse Prolongevity Paradigms
Cedillo, L.; Li, S.; Ahsan, F.; Stuhr, N. L.; Zhou, Y.; Zhang, Y.; Adedoja, A.; Murphy, L. M.; Yerevanian, A.; Emans, S.; Dao, K.; Li, Z.; Peterson, N. D.; Watrous, J.; Jain, M.; Das, S.; Pukkila-Worley, R.; Curran, S. P.; Soukas, A. A.
10.1101/2021.09.02.457410 — genetics — Posted on 2022-07-27
434 G-Trap Assay I: Small GTPases as sensitive immune response biomarkers for active bacteremia
Clark, R.; Bondu, V.; Simons, P. C.; Shevy, L.; Castillo, E. F.; Young, S.; Kanagy, N.; Wandinger-Ness, A.; Howdieshell, T.; Buranda, T.
10.1101/2022.06.09.495550 — immunology — Posted on 2022-07-27
439 Improved Docking of Protein Models by a Combination of Alphafold2 and ClusPro
Ghani, U.; Desta, I.; Jindal, A.; Khan, O.; Jones, G.; Hashemi, N.; Kotelnikov, S.; Padhorny, D.; Vajda, S.; Kozakov, D.
10.1101/2021.09.07.459290 — bioinformatics — Posted on 2022-07-27
440 Loss of DMD gene expression results in Duchenne-like molecular abnormalities across diverse tissues.
Alnassar, N.; Borczyk, M.; Tsagkogeorga, G.; Korostynski, M.; Han, N.; Gorecki, D. C.
10.1101/2022.04.04.486990 — genetics — Posted on 2022-07-27
444 High-throughput small molecule screen identifies inhibitors of microsporidia invasion and proliferation in C. elegans.
Murareanu, B. M.; Antao, N. V.; Zhao, W.; Dubuffet, A.; El Alaoui, H.; Knox, J.; Ekiert, D. C.; Bhabha, G.; Roy, P.; Reinke, A. W.
10.1101/2021.09.06.459184 — microbiology — Posted on 2022-07-27
445 Integrated single-cell multiomic analysis of HIV latency reversal reveals novel regulators of viral reactivation.
Manickam, A.; Peterson, J. J.; Harigaya, Y.; Murdoch, D. M.; Margolis, D. M.; Oesterling, A.; Guo, Z.; Rudin, C. D.; Jiang, Y.; Browne, E. P.
10.1101/2022.07.26.501558 — microbiology — Posted on 2022-07-27
446 Comparative genome-scale constraint-based metabolic modeling reveals key lifestyle features of plant-associated Pseudomonas spp.
Poncheewin, W.; van Diepeningen, A. D.; van der Lee, T. A. J.; Schaap, P. J.; Martins dos Santos, V. A. P.; Suarez-Diez, M.
10.1101/2022.07.26.501552 — systems biology — Posted on 2022-07-27
447 APC and P53 mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer
Tian, Y.; Wang, X.; Cramer, Z.; Rhoades, J.; Estep, K. N.; Ma, X.; Tzivelekidis, S. A.; Katona, B. W.; Johnson, F. B.; Yu, Z.; Blanco, M. A.; Lengner, C.; Li, N.
10.1101/2022.07.26.501557 — cancer biology — Posted on 2022-07-27
448 Robust Harmonization of Microbiome Studies by Phylogenetic Scaffolding with MaLiAmPi
Minot, S. S.; Garb, B.; Roldan, A.; Tang, A.; Oskotsky, T.; Rosenthal, C.; Hoffman, N. G.; Sirota, M.; Golob, J. L.
10.1101/2022.07.26.501561 — bioinformatics — Posted on 2022-07-27
450 Epigenome-wide meta-analysis of BMI in nine population-based cohorts: examining the utility of methylation as a biomarker of BMI
Do, W. L.; Sun, D.; Meeks, K. A.; Dugue, P.-A.; Demerath, E. W.; Guan, W.; Li, S.; Chen, W.; Milne, R. L.; Adeyemo, A.; Agyemang, C.; Nassir, R.; Manson, J. E.; Shadyab, A. H.; Hou, L.; Horvath, S.; Assimes, T. L.; Bhatti, P.; Jordahl, K. M.; Baccarelli, A. A.; Smith, A.; Staimez, L. R.; Stein, A. D.; Whitsel, E. A.; Narayan, K. M. V.; Conneely, K. N.
10.1101/2022.07.26.498234 — genetics — Posted on 2022-07-27
455 Evaluating the capabilities and challenges of layer-fMRI VASO at 3T
Huber, L.; Kronbichler, L.; Stirnberg, R.; Ehses, P.; Stoecker, T.; Fernandez-Cabello, S.; Poser, B. A.; Kronbichler, M.
10.1101/2022.07.26.501554 — neuroscience — Posted on 2022-07-27
456 Revealing the Neurobiology Underlying Interpersonal Neural Synchronization with Multimodal Data Fusion
Lotter, L. D.; Kohl, S. H.; Gerloff, C.; Bell, L.; Niephaus, A.; Kruppa, J. A.; Dukart, J.; Schulte-Rüther, M.; Reindl, V.; Konrad, K.
10.1101/2022.07.26.501562 — neuroscience — Posted on 2022-07-27
459 Connectome spectrum electromagnetic tomography: a method to reconstruct electrical brain sources at high-spatial resolution
Rue Queralt, J.; Fluhr, H.; Tourbier, S.; Aleman Gomez, Y.; Pascucci, D.; Yerly, J.; Glomb, K.; Plomp, G.; Hagmann, P.
10.1101/2022.07.26.501544 — neuroscience — Posted on 2022-07-27
460 Neural integration and segregation revealed by a joint time-vertex connectome spectral analysis
Rue Queralt, J.; Mancini, V.; Rochas, V.; Latreche, C.; Uhlhaas, P.; Michel, C.; Plomp, G.; Eliez, S.; Hagmann, P.
10.1101/2022.07.26.501543 — neuroscience — Posted on 2022-07-27
465 The PREGCARE study: Personalized recurrence risk assessment following the birth of a child with a pathogenic de novo mutation
Bernkopf, M.; Abdullah, U. B.; Bush, S. J.; Wood, K.; Ghaffari, S.; Giannoulatou, E.; Koelling, N.; Maher, G.; Thibaut, L. M.; Williams, J.; Blair, E. M.; Blanco Kelly, F.; Bloss, A.; Burkitt-Wright, E.; Canham, N.; Deng, A. T.; Dixit, A.; Eason, J.; Elmslie, F.; Gardham, A.; Hay, E.; Holder, M.; Homfray, T.; Hurst, J. A.; Johnson, D.; Jones, W. D.; Kini, U.; Kivuva, E.; Kumar, A.; Lees, M. M.; Leitch, H. G.; Morton, J. E.; Nemeth, A. H.; Ramachandrappa, S.; Saunders, K.; Shears, D. J.; Side, L.; Splitt, M.; Stewart, A.; Stewart, H.; Suri, M.; Clouston, P.; Davies, R. W.; Wilkie, A. O.; Goriel
10.1101/2022.07.26.501520 — genetics — Posted on 2022-07-27
470 Hidden species diversity in a living fossil vertebrate
Brownstein, C. D.; Kim, D.; Orr, O. D.; Hogue, G. M.; Tracy, B. H.; Pugh, M. W.; Singer, R.; Myles-McBurney, C.; Mollish, J. M.; Simmons, J. W.; David, S. R.; Watkins-Colwell, G.; Hoffman, E. A.; Near, T. J.
10.1101/2022.07.25.500718 — evolutionary biology — Posted on 2022-07-27
471 The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes
Santini, S.; Schenkelaars, Q.; Jourda, C.; Duschene, M.; Belahbib, H.; Rocher, C.; Selva, M.; Riesgo, A.; Vervoort, M.; Leys, S. P.; Kodjabachian, L.; Le Bivic, A.; Borchiellini, C.; Claverie, J.-M.; Renard, E.
10.1101/2022.07.26.501511 — evolutionary biology — Posted on 2022-07-27
473 Exploring Neural Heterogeneity in Inattention and Hyperactivity
Zdorovtsova, N.; Jones, J. S.; Akarca, D.; Benhamou, E.; Astle, D. E.
10.1101/2022.07.26.501508 — neuroscience — Posted on 2022-07-27
474 Fully Desktop Fabricated Flexible Graphene Electrocorticography (ECoG) Arrays
Hu, J.; Hossain, R. F.; Navabi, Z. S.; Tillery, A.; Laroque, M.; Donaldson, P. D.; Swisher, S. L.; Kodandaramaiah, S. B.
10.1101/2022.07.25.501414 — neuroscience — Posted on 2022-07-27
478 TM-Vec: template modeling vectors for fast homology detection and alignment
Hamamsy, T.; Morton, J.; Berenberg, D.; Carriero, N.; Gligorijevic, V.; Blackwell, R.; Strauss, C.; Leman, J. K.; Cho, K.; Bonneau, R.
10.1101/2022.07.25.501437 — bioinformatics — Posted on 2022-07-27
479 Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock
Ahadi, S.; Wilson, K. A.; Babenko, B.; McLean, C. Y.; Bryant, D.; Pritchard, O.; Carrera, E. M.; Lamy, R.; Stewart, J. M.; Varadarajan, A.; Berndl, M.; Kapahi, P.; Bashir, A.
10.1101/2022.07.25.501485 — bioinformatics — Posted on 2022-07-27
480 Cell type directed design of synthetic enhancers
Taskiran, I. I.; Spanier, K. I.; Christiaens, V.; Mauduit, D.; Aerts, S.
10.1101/2022.07.26.501466 — genomics — Posted on 2022-07-27
483 Diverse logics and grammar encode notochord enhancers
Song, B. P.; Ragsac, M. F.; Tellez, K.; Jindal, G. A.; Grudzien, J. L.; Le, S. H.; Farley, E. K.
10.1101/2022.07.25.501440 — developmental biology — Posted on 2022-07-27
493 Chlamydomonas reinhardtii triose-phosphate/phosphate translocator3 (TPT3): A major chloroplast shunt for the export of fixed carbon and reductant
Huang, W.; Krishnan, A.; Plett, A.; Meagher, M.; Linka, N.; Ren, B.; Findinier, J.; Redekop, P.; Fakhimi, N.; Xu, J.; Kim, R. G.; Karns, D. A.; Boyle, N.; Posewitz, M.; Grossman, A. R.
10.1101/2022.07.25.501471 — plant biology — Posted on 2022-07-27
494 The response mechanism of oreorchis patens (Lindl.) Lindl. to cold stress
Yu, L.; Xu, Y.; Zhang, Y.; Shao, M.; Miao, Q.; Chen, X.; Yang, H.; Cui, N.; Qu, B.
10.1101/2022.07.25.501424 — plant biology — Posted on 2022-07-27
496 REDIRECTION: Generating drug repurposing hypotheses using link prediction with DISNET data
Ayuso Munoz, A.; Ugarte Carro, E.; Prieto Santamaria, L.; Otero Carrasco, B.; Menasalvas Ruiz, E.; Perez Gallardo, Y.; Rodriguez-Gonzalez, A.
10.1101/2022.07.26.501105 — bioinformatics — Posted on 2022-07-27
499 Optimisation and Pre-clinical Demonstration of Temporal Diffusion Ratio for Imaging Restricted Diffusion
Warner, W.; Palombo, M.; Cruz, R.; Shemesh, N.; Jones, D.; Dell'Acqua, F.; Ianus, A.; Drobnjak, I.
10.1101/2022.07.25.500826 — bioengineering — Posted on 2022-07-27
502 Seasonality of host-seeking Ixodes ricinus nymph abundance in relation to climate
Hoch, T.; Madouasse, A.; Jacquot, M.; Wongnak, P.; Beugnet, F.; Bournez, L.; Huard, F.; Moutailler, S.; Plantard, O.; Poux, V.; Rene-Martellet, M.; Vayssier-Taussat, M.; Verheyden, H.; Vourc'h, G.; Chalvet-Monfray, K.; Agoulon, A.
10.1101/2022.07.25.501416 — ecology — Posted on 2022-07-27
503 Human-environment feedback and the consistency of proenvironmental behaviour
Ecotiere, C. D.; Billiard, S.; Andre, J.-B.; Collet, P.; Ferriere, R.; Meleard, S.
10.1101/2022.07.23.501219 — ecology — Posted on 2022-07-27
504 Morphine Suppresses Peripheral Responses and Transforms Brain Myeloid Gene Expression to Favor Neuropathogenesis in SIV Infection
Fox, H. S.; Niu, M.; Morsey, B. M.; Lamberty, B. G.; Emanuel, K.; Periyasamy, P.; Callen, S.; Acharya, A.; Kubik, G.; Eudy, J. D.; Guda, C.; Dyavar, S. R.; Fletcher, C. V.; Byrareddy, S.; Buch, S.
10.1101/2022.07.25.501436 — neuroscience — Posted on 2022-07-27
508 On the functional role of gamma synchronization in the retinogeniculate system of the cat
Neuenschwander, S.; Rosso, G.; Branco, N.; Freitag, F.; Tehovnik, E. J.; Schmidt, K. E.; Baron, J.
10.1101/2022.07.25.501474 — neuroscience — Posted on 2022-07-27
512 Explanatory latent representation of heterogeneous spatial maps of task-fMRI in large-scale datasets
Zabihi, M.; Kia, S. M.; Wolfers, T.; de Boer, s.; fraza, c.; soheili-nezhad, s.; Dinga, R.; Llera, A.; Bzdok, D.; Beckmann, C.; marquand, A.
10.1101/2021.03.10.434856 — neuroscience — Posted on 2022-07-27
514 Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility
Guntupalli, S.; Park, P.; Han, D. H.; Ringuet, M.; Blackmore, D. G.; Jhaveri, D. J.; Koentgen, F.; Widagdo, J.; Kaang, B.-K.; Anggono, V.
10.1101/2022.07.27.501670 — neuroscience — Posted on 2022-07-27
515 Towards the Myoelectric Digital Twin: Ultra Fast and Realistic Modelling for Deep Learning
Maksymenko, K.; Clarke, A. K.; Guerra, I. M.; Deslauriers-Gauthier, S.; Farina, D.
10.1101/2021.06.07.447390 — bioengineering — Posted on 2022-07-27
518 Developing Wolbachia-based disease interventions for an extreme environment
Ross, P. A.; Elfekih, S.; Collier, S.; Klein, M. J.; Lee, S. S.; Dunn, M.; Jackson, S.; Zhang, Y.; Axford, J. K.; Gu, X.; Nasar, M. S.; Paradkar, P. N.; Tawfik, E. A.; Jiggins, F. M.; Almalik, A. M.; Al-Fageeh, M. B.; Hoffmann, A. A.
10.1101/2022.07.26.501527 — evolutionary biology — Posted on 2022-07-27
521 Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure
Bustamante, J.; Padilla, A.; White, B.; Auckland, L.; Busselman, R.; Collins, S.; Malcolm, E.; Wilson, B.; Saunders, A.; Hamer, S.; Tarleton, R. L.
10.1101/2022.07.25.501361 — microbiology — Posted on 2022-07-27
525 Microtubule severing enzymes oligomerization and allostery: a tale of two domains
Macke, A. C.; Kelly, M. S.; Varikoti, R. A.; Groves, D.; Forbes, C.; Mullen, S.; Dima, R. I.
10.1101/2022.07.26.501617 — biophysics — Posted on 2022-07-27
531 Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue remodeling in the pancreas
Burdziak, C.; Alonso-Curbelo, D.; Walle, T.; Barriga, F. M.; Reyes, J.; Xie, Y.; Zhao, Z.; Zhao, C. J.; Chen, H.-A.; Chaudhary, O.; Masilionis, I.; Choo, Z.-N.; Gao, V.; Luan, W.; Wuest, A.; Ho, Y.-J.; Wei, Y.; Quail, D.; Koche, R.; Mazutis, L.; Nawy, T.; Chaligne, R.; Lowe, S. W.; Pe'er, D.
10.1101/2022.07.26.501417 — cancer biology — Posted on 2022-07-27
532 Developing Wolbachia-based disease interventions for an extreme environment
Ross, P. A.; Elfekih, S.; Collier, S.; Klein, M. J.; Lee, S. S.; Dunn, M.; Jackson, S.; Zhang, Y.; Axford, J. K.; Gu, X.; Nasar, M. S.; Paradkar, P. N.; Taoufik, E. A.; Jiggins, F. M.; Almalik, A. M.; Al-Fageeh, M. B.; Hoffmann, A. A.
10.1101/2022.07.26.501527 — evolutionary biology — Posted on 2022-07-27
533 Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines
Schwörer, S.; Ros, M.; Tsanov, K. M.; Cimino, F. V.; Lowe, S. W.; Carmona-Fontaine, C.; Thompson, C. B.
10.1101/2022.07.26.501639 — cell biology — Posted on 2022-07-27
537 A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals
Martynowycz, M. W.; Shiriaeva, A.; Clabbers, M. T. B.; Nicolas, W. J.; Weaver, S. J.; Hattne, J.; Gonen, T.
10.1101/2022.07.26.501628 — biochemistry — Posted on 2022-07-26
543 Function and evolution of aquaporin IsAQP1 in the Lyme disease vector Ixodes scapularis
Tsujimoto, H.; Metz, H. C.; Smith, A. A.; Sakamoto, J. M.; Pal, U.; Rasgon, J. L.
10.1101/2022.07.26.501577 — genetics — Posted on 2022-07-27
545 Protein Complexes in Bacillus subtilis by AI-assisted structural proteomics
O'Reilly, F. J.; Graziadei, A.; Forbrig, C.; Bremenkamp, R.; Charles, K.; Lenz, S.; Elfmann, C.; Fischer, L.; Stuelke, J.; Rappsilber, J.
10.1101/2022.07.26.501605 — molecular biology — Posted on 2022-07-26
547 Early-childhood inflammation blunts the transcriptional maturation of cerebellar neurons
Ament, S. A.; Cortes-Gutierrez, M.; Herb, B. R.; Mocci, E.; Colantuoni, C.; McCarthy, M. M.
10.1101/2022.07.26.501598 — genomics — Posted on 2022-07-26
551 Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways
McCourt, J. L.; Stearns-Reider, K. M.; Mamsa, H.; Shu, C.; Afsharinia, M. H.; Gibbs, E. M.; Shin, K. M.; Kurmangaliyev, Y.; Schmitt, L. R.; Hansen, K.; Crosbie, R. H.
10.1101/2022.07.26.501621 — molecular biology — Posted on 2022-07-26
557 Genomics of viruses infecting green and purple sulfur bacteria in two euxinic lakes
Hesketh-Best, P. J.; Bosco-Santos, A.; Garcia, S. L.; Werne, J. P.; Gilhooly, W. P.; Silveira, C. B.
10.1101/2022.07.26.501573 — microbiology — Posted on 2022-07-26
561 Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness
Keller, L. J.; Nguyen, T. H.; Liu, L.; Lakemeyer, M.; Gelsinger, D. J.; Chanin, R.; Ngo, N.; Lum, K. M.; Faucher, F.; Ipock, P.; Niphakis, M.; Bhatt, A. S.; O'Donoghue, A. j.; Huang, K.; Bogyo, M.
10.1101/2022.07.25.501481 — microbiology — Posted on 2022-07-26
567 Intestinal epithelial MHC class II regulation by HDAC3 instructs microbiota-specific CD4+ T cells
Eshleman, E. M.; Shao, T.-Y.; Woo, V.; Rice, T.; Whitt, J.; Engleman, L.; Way, S. S.; Alenghat, T.
10.1101/2022.01.01.473735 — immunology — Posted on 2022-07-26
568 A Glass Phase Plate for Wavelength SensitiveSuperresolution Microscopy
Fernando, S. I.; Martineau, J. T.; Vu, T. N.; Baker, B.; Hobson, R. J.; Mueller, B.; Menon, R.; Jorgensen, E. M.; Gerton, J. M.
10.1101/2022.07.11.499581 — biophysics — Posted on 2022-07-26
569 Multi-omics profiling, in vitro and in vivo enhancer assays dissect the cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy
Van de Sompele, S.; Small, K. W.; Cicekdal, M. B.; Soriano, V. L.; D'haene, E.; Shaya, F. S.; Agemy, S.; Van der Snickt, T.; Rey, A. D.; Rosseel, T.; Van Heetvelde, M.; Vergult, S.; Balikova, I.; Bergen, A. A.; Boon, C. J. F.; De Zaeytijd, J.; Inglehearn, C. F.; Kousal, B.; Leroy, B. P.; Rivolta, C.; Vaclavik, V.; van den Ende, J.; van Schooneveld, M. J.; Gomez-Skarmeta, J. L.; Tena, J. J.; Martinez-Morales, J. R.; Liskova, P.; Vleminckx, K.; De Baere, E.
10.1101/2022.03.08.481329 — genomics — Posted on 2022-07-26
571 A Systematic Interrogation of MHC Class I Peptide Presentation Identifies Constitutive and Compensatory Protein Degradation Pathways
Mamrosh, J. L.; Sherman, D. J.; Cohen, J. R.; Johnston, J. A.; Joubert, M. K.; Li, J.; Lipford, J. R.; Lomenick, B.; Moradian, A.; Prabhu, S.; Sweredoski, M. J.; Vander Lugt, B.; Verma, R.; Deshaies, R. J.
10.1101/2021.10.07.463289 — molecular biology — Posted on 2022-07-26
572 Vaginal microbiota of adolescents and their mothers: A preliminary study of vertical transmission and persistence
Bassis, C. M.; Bullock, K. A.; Sack, D. E.; Saund, K.; Pirani, A.; Snitkin, E. S.; Alaniz, V. I.; Quint, E. H.; Young, V. B.; Bell, J. D.
10.1101/768598 — microbiology — Posted on 2022-07-26
574 The intestinal circadian clock drives microbial rhythmicity to maintain gastrointestinal homeostasis
Heddes, M.; Altaha, B.; Niu, Y.; Reitmeier, S.; Kleigrewe, K.; Haller, D.; Kiessling, S.
10.1101/2021.10.18.464061 — physiology — Posted on 2022-07-26
575 SARS-CoV-2 Non-Structural Protein 1(NSP1) Mutation Virulence and Natural Selection: Evolutionary Trends in the Six Continents
Salami Ghaleh, S.; Rahimian, K.; Mahmanzar, M.; Mahdavi, B.; Tokhanbigli, S.; Mollapour Sisakht, M.; Farhadi, A.; Mousakhan Bakhtiari, M.; Lee Kuehu, D.; Deng, Y.
10.1101/2022.07.22.501212 — bioinformatics — Posted on 2022-07-26
576 Fusing an agent-based model of mosquito population dynamics with a statistical reconstruction of spatio-temporal abundance patterns
Cavany, S. M.; Espana, G.; Lloyd, A. L.; Vazquez-Prokopec, G.; Astete, H.; Waller, L.; Kitron, U.; Scott, T. W.; Morrison, A. C.; Reiner, R.; Perkins, T. A.
10.1101/2022.07.25.501354 — ecology — Posted on 2022-07-26
577 Partitioned Local Depth analysis of time course transcriptomic data reveals elaborate community structure
Khoury, M.; Berenhaut, K.; Moore, K.; Allen, E.; Harkey, A.; Muhlemann, J. K.; Craven, C.; Xu, J.; Jain, S.; John, D.; Norris, J.; Muday, G. K.
10.1101/2022.07.25.501352 — systems biology — Posted on 2022-07-26
578 Ecosystem services in connected catchment to coast ecosystems: monitoring to detect emerging trends
Brown, C. J.; Saint Ange, C.; Connolly, R.; Hasan, S.; Jackson, S.; McMahon, J.; Smart, J.
10.1101/2021.07.19.453015 — ecology — Posted on 2022-07-26
580 VCP/p97 extracts DNA polymerase alfa/Primase from chromatin to limit the activation of the replication stress response
Rodriguez-Acebes, S.; Martin-Rufo, R.; Fernandez-Llorente, A.; de la Vega-Barranco, G.; Oroz, P.; Martin-Doncel, E.; Toledo, L.; Mendez, J.; Lecona, E.
10.1101/2022.07.25.501345 — molecular biology — Posted on 2022-07-26
581 Intranasal delivery of lipid nanoparticle encapsulated SARS-CoV-2 and RSV-targeting siRNAs reduces lung infection
Supramaniam, A.; Tayyar, Y.; Clarke, D. T.; Kelly, G.; Morris, K. V.; McMillan, N. A.; Idris, A.
10.1101/2022.07.25.501479 — microbiology — Posted on 2022-07-26
582 Primary Omicron infection elicits weak antibody response but robust cellularimmunity in children
Dowell, A. C.; Lancaster, T.; Bruton, R.; Ireland, G.; Bentley, C.; Sylla, P.; Zuo, J.; Scott, S.; Jardin, A.; Begum, J.; Roberts, T.; Stephens, C.; Amin, U.; Ditta, S.; Shepherdson, R.; Powell, A.; Brent, A.; Brent, B.; Baawuah, F.; Okike, I.; Beckmann, J.; Ahmad, S.; Aiano, F.; Garstang, J.; Ramsay, M.; Azad, R.; Waiblinger, D.; Willet, B.; Wright, J.; Ladhani, S.; Moss, P.
10.1101/2022.07.26.501570 — immunology — Posted on 2022-07-26
583 L.interrogans prevents macrophage death and pyroptotic IL1β release through its lipopolysaccharide
Bonhomme, D.; Hernandez-Trejo, V.; Papadopoulos, S.; Pigache, R.; Fanton d'Andon, M.; Outlioua, A.; GOMPERTS BONECA, I.; Werts, C.
10.1101/2022.07.25.501344 — immunology — Posted on 2022-07-26
584 Microcephaly-associated WDR62 mutations hamper Golgi apparatus-to-spindle pole shuttling in human neural progenitors
dell'Amico, C.; Angulo Salavarria, M. M.; Takeo, Y.; Saotome, I.; Dell'Anno, M. T.; Galimberti, M.; Pellegrino, E.; Cattaneo, E.; Louvi, A.; Onorati, M.
10.1101/2022.07.24.501306 — neuroscience — Posted on 2022-07-26
585 Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter
Li, F.; Eriksen, J.; Oses-Prieto, J. A.; Gomez, Y. K.; Xu, H.; Finer-Moore, J.; Nguyen, P.; Bowen, A.; Nelson, A.; Burlingame, A.; Grabe, M.; Stroud, R.; Edwards, R.
10.1101/2022.07.26.501550 — biochemistry — Posted on 2022-07-26
587 Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive crystal contacts
Ye, M.; Makola, M.; Newman, J.; Fairhead, M.; MacLean, E.; Wright, N. D.; Koekemoer, L.; Thompson, A.; Bezerra, G. A.; Yi, G.; Li, H.; Rangel, V. L.; Mamalis, D.; Aitkenhead, H.; Davis, B. G.; Gilbert, R. J. C.; Duerr, K.; Gileadi, O.; von Delft, F.
10.1101/2022.07.26.501559 — biochemistry — Posted on 2022-07-26
589 Trophoblast glycoprotein is required for efficient synaptic vesicle exocytosis from retinal rod bipolar cells.
Wakeham, C. M.; Shi, Q.; Ren, G.; Haley, T. L.; Duvoisin, R.; von Gersdorff, H.; Morgans, C. W.
10.1101/2022.07.25.501380 — neuroscience — Posted on 2022-07-26
591 Impact of storage on starch digestibility and texture of a high-amylose wheat bread
Corrado, M.; Zafeiriou, P.; Ahn-Jarvis, J. H.; Savva, G. M.; Edwards, C. H.; Hazard, B. A.
10.1101/2022.07.04.498686 — biochemistry — Posted on 2022-07-26
592 Increased homozygosity due to endogamy results in fitness consequences in a human population
Swinford, N.; Prall, S.; Williams, C. M.; Sheehama, J.; Scelza, B.; Henn, B. M.
10.1101/2022.07.25.501261 — genetics — Posted on 2022-07-26
595 Citrus relatives exhibit natural variation in perception and response magnitude to microbial features
Trinh, J.; Li, T.; Franco, J. Y.; Toruno, T. Y.; Stevens, D. M.; Thapa, S. P.; Wong, J.; Pineda, R.; Avila de Dios, E.; Kahn, T. L.; Seymour, D. K.; Ramadugu, C.; Coaker, G. L.
10.1101/2022.07.15.500235 — plant biology — Posted on 2022-07-26
597 A global meta-analysis reveals higher variation in breeding phenology in urban birds than in their non-urban neighbours
Capilla-Lasheras, P.; Thompson, M. J.; Sanchez-Tojar, A.; Haddou, Y.; Branston, C. J.; Reale, D.; Charmantier, A.; Dominoni, D. M.
10.1101/2021.09.24.461498 — evolutionary biology — Posted on 2022-07-26
598 Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled
Ronzano, R.; Skarlatou, S.; Barriga, B. K.; Bannatyne, B. A.; Bhumbra, G. S.; Foster, J. D.; Moore, J.; Lancelin, C.; Pocratsky, A.; Ozyurt, M. G.; Smith, C. C.; Todd, A. J.; Maxwell, D. J.; Murray, A. J.; Pfaff, S. L.; Brownstone, R. M.; Zampieri, N.; Beato, M.
10.1101/2021.02.10.430608 — neuroscience — Posted on 2022-07-26
601 A novel RORγt+ antigen presenting cell type instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life
Akagbosu, B.; Tayyebi, Z.; Shibu, G.; Paucar Iza, Y. A.; Deep, D.; Franco Parisotto, Y.; Pasolli, H. A.; Thevin, V.; Elmentaite, R.; Knott, M.; Hemmers, S.; Jahn, L.; Friedrich, C.; Verter, J.; Wang, Z.; van den Brink, M.; Gasteiger, G.; Grünewald, T. G. P.; Marie, J.; Leslie, C.; Rudensky, A. Y.; Brown, C. C.
10.1101/2022.02.26.481148 — immunology — Posted on 2022-07-26
603 Critical role of PCYT2 in muscle health and aging
Cikes, D.; Elsayad, K.; Sezgin, E.; Koitai, E.; Ferenc, T.; Orthofer, M.; Yarwood, R.; Heinz, L.; Sedlyarov, V.; Darwish-Miranda, N.; Taylor, A.; Grapentine, S.; al-Murshedi, F.; Abot, A.; Weidinger, A.; Kutchukian, C.; Sanchez, C.; Cronin, S. J. F.; Novatchkova, M.; Kavirayani, A.; Schuetz, T.; Haubner, B.; Haas, L.; Hagelkrueys, A.; Jackowski, S.; Kozlov, A.; Jacquemond, V.; Knauf, C.; Superti-Furga, G.; Rullman, E.; Gustafsson, T.; McDermott, J. H.; Lowe, M. P.; Radak, Z.; Chamberlain, J. S.; Bakovic, M.; Banka, S.; Penninger, J.
10.1101/2022.03.02.482658 — genetics — Posted on 2022-07-26
612 Obesity promotes Fumonisin B1 toxicity and induces hepatitis
Dopavogui, L.; Regnier, M.; Polizzi, A.; Ponchon, Q.; Smati, S.; Klement, W.; Lasserre, F.; Lukowicz, C.; Lippi, Y.; Fougerat, A.; Bertrand-Michel, J.; Naylies, C.; Canlet, C.; Debrauwer, L.; Gamet-Payrastre, L.; Dauriat, C.; Casas, J.; Croubels, S.; De Baere, S.; Burger, H. M.; Chassaing, B.; Ellero-Simatos, S.; Guillou, H.; Oswald, I. P.; Loiseau, N.
10.1101/2022.07.22.500801 — pharmacology and toxicology — Posted on 2022-07-26
613 Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish
Travnickova, J.; Muise, S.; Wojciechowska, S.; Brombin, A.; Zeng, Z.; Young, A. I.; Wyatt, C.; Patton, E. E.
10.1101/2022.03.17.484741 — cancer biology — Posted on 2022-07-26
615 Nanoparticles targeted to fibroblast activation protein outperform PSMA for MRI delineation of primary prostate tumours
Dmochowska, N.; Milanova, V.; Mukkamala, R.; Chow, K. K.; Pham, N. T.; Srinivasarao, M.; Ebert, L. M.; Stait-Gardner, T.; Le, H.; Shetty, A.; Nelson, M.; Low, P. S.; Thierry, B.
10.1101/2022.06.10.495719 — bioengineering — Posted on 2022-07-26
617 Unsupervised determination of lung tumor margin with widefield polarimetric second-harmonic generation microscopy
Mirsanaye, K.; Castano, L. U.; Kamaliddin, Y.; Golaraei, A.; Kontenis, L.; Zurauskas, E.; Navab, R.; Yasufuku, K.; Tsao, M.-S.; Wilson, B. C.; Barzda, V.
10.1101/2022.07.25.501438 — pathology — Posted on 2022-07-26
619 Automatic discrimination of species within the Enterobacter cloacae complex using MALDI-TOF Mass Spectrometry and supervised algorithms
Candela, A.; Guerrero-Lopez, A.; Mateos, M.; Gomez Asenjo, A.; Arroyo, M. J.; Hernandez-Garcia, M.; del Campo, R.; Cercenado, E.; Cuenod, A.; Mendez, G.; Mancera, L.; Caballero, J. d. D.; Martinez-Garcia, L.; Gijon, D.; Morosini, M. I.; Ruiz-Garbajosa, P.; Egli, A.; Canton, R.; Munoz, P.; Rodriguez-Temporal, D.; Rodriguez-Sanchez, B.
10.1101/2021.11.02.467040 — microbiology — Posted on 2022-07-26
620 Spatial representation by ramping activity of neurons in the retrohippocampal cortex
Tennant, S.; Clark, H.; Hawes, I.; Tam, W. K.; Hua, J.; Yang, W.; Gerlei, K.; Wood, E.; Nolan, M. F.
10.1101/2021.03.15.435518 — neuroscience — Posted on 2022-07-26
621 Dynamic metabolome profiling uncovers potential TOR signaling genes
Reichling, S.; Doubleday, P. F.; Germade, T.; Bergmann, A.; Loewith, R.; Sauer, U.; Holbrook-Smith, D.
10.1101/2022.07.25.500770 — systems biology — Posted on 2022-07-26
623 Early pre-neural serotonin modulates balance of late monoamines and behavioral patterns in fish model system
Ivashkin, E.; Spulber, S.; Zinovyev, A.; Yoshitake, T.; Yoshitake, S.; Kharchenko, O.; Khabarova, M. Y.; Theofilopoulos, S.; Kehr, J.; Arenas, E.; Ceccatelli, S.; Voronezhskaya, E. E.; Adameyko, I.
10.1101/2022.07.25.501403 — developmental biology — Posted on 2022-07-26
624 Transient inhibition of translation improves long-term cardiac function after ischemia/reperfusion by attenuating the inflammatory response
Hofmann, C.; Serafin, A.; Schwerdt, O. M.; Younesi, F. S.; Sicklinger, F.; Meyer, I. S.; Malovrh, E.; Sandmann, C.; Juergensen, L.; Kamuf-Schenk, V.; Stroh, C.; Loewenthal, Z.; Rettel, M.; Stein, F.; Katus, H. A.; Jakobi, T.; Frey, N.; Leuschner, F.; Voelkers, M.
10.1101/2022.07.25.501397 — molecular biology — Posted on 2022-07-26
627 A deeply conserved protease, acylamino acid-releasing enzyme (AARE), acts in plant ageing
Hoernstein, S. N. W.; Oezdemir, B.; van Gessel, N.; Miniera, A. A.; Rogalla von Bieberstein, B.; Nilges, L.; Schweikert Farinha, J.; Komoll, R.; Glauz, S.; Weckerle, T.; Scherzinger, F.; Rodriguez-Franco, M.; Mueller-Schuessele, S. J.; Reski, R.
10.1101/2022.05.18.492440 — plant biology — Posted on 2022-07-26
628 Tumor suppressor Hypermethylated in Cancer 1 represses expression of cell cycle regulator E2F7 in human primary cells
Lanikova, L.; Svec, J.; Janeckova, L.; Pospichalova, V.; Dibus, N.; Vojtechova, M.; Hrckulak, D.; Sloncova, E.; Strnad, H.; Korinek, V.
10.1101/2022.07.25.501405 — cancer biology — Posted on 2022-07-25
629 Single-molecule tracking reveals two low-mobility states for chromatin and transcriptional regulators within the nucleus
Wagh, K.; Stavreva, D. A.; Jensen, R. A.; Paakinaho, V.; Fettweis, G.; Schiltz, R. L.; Wüstner, D.; Mandrup, S.; Presman, D. M.; Upadhyaya, A.; Hager, G. L.
10.1101/2022.07.25.501476 — biophysics — Posted on 2022-07-25
631 Telomere-to-telomere genome assembly of matsutake (Tricholoma matsutake)
Kurokochi, H.; Tajima, N.; Sato, M. P.; Yoshitake, K.; Asakawa, S.; Isobe, S.; Shirasawa, K.
10.1101/2022.07.25.501483 — genomics — Posted on 2022-07-25
632 Extrachromosomal DNA in the cancerous transformation of Barrett's esophagus
Luebeck, J.; Ng, A. W. T.; Galipeau, P. C.; Li, X.; Sanchez, C. A.; Katz-Summercorn, A.; Kim, H.; Jammula, S.; He, Y.; Lippman, S. M.; Verhaak, R. G. W.; Maley, C. C.; Alexandrov, L. B.; Reid, B. J.; Fitzgerald, R. C.; Paulson, T. G.; Chang, H. Y.; Wu, S.; Bafna, V.; Mischel, P. S.
10.1101/2022.07.25.501144 — genomics — Posted on 2022-07-25
635 Methylation genome wide profiling in lowly and highly efficient adipose somatic cell nuclear transfer in pigs
Grzybek, M.; Flisikowski, K.; Giles, T.; Dyjak, M.; Ploski, R.; Gasperowicz, P.; Emes, R. D.; Lisowski, P.
10.1101/2022.07.25.501434 — genetics — Posted on 2022-07-25
637 Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes
Nishino, T.; Ranade, S.; Pelonero, A.; van Soldt, B. J.; Ye, L.; Alexanian, M.; Koback, F.; Huang, Y.; Sadagopan, N.; Padmanabhan, A.; Thomas, R.; van Bemmel, J. G.; Gifford, C. A.; Costa, M. W.; Srivastava, D.
10.1101/2022.07.25.501463 — developmental biology — Posted on 2022-07-25
638 Single Cell Epigenetics Reveal Cell-Cell Communication Networks in Normal and Abnormal Cardiac Morphogenesis
Ranade, S.; Whalen, S.; Zlatanova, I.; Nishino, T.; van Soldt, B.; Ye, L.; Pelonero, A.; Wallace, L. G.; Huang, Y.; Alexanian, M.; Padmanabhan, A.; Teran, B. G.; Przytycki, P.; Costa, M. W.; Gifford, C. A.; Black, B.; Pollard, K. S.; Srivastava, D.
10.1101/2022.07.25.501458 — developmental biology — Posted on 2022-07-25
639 Nuclear Location Bias of HCAR1 Drives Cancer Malignancy through Numerous Routes
Nezhady, M. A. M.; Cagnone, G.; Bajon, E.; Chaudhari, P.; Modaresinejad, M.; Hardy, P.; Maggiorani, D.; Quiniou, C.; Joyal, J.-S.; Beausejour, C.; Chemtob, S.
10.1101/2022.07.25.501445 — cell biology — Posted on 2022-07-25
640 Glutamine synthetase mRNA releases sRNA from its 3'UTR to regulate carbon/nitrogen metabolic balance
Miyakoshi, M.; Morita, T.; Kobayashi, A.; Berger, A.; Takahashi, H.; Gotoh, Y.; Hayashi, T.; Tanaka, K.
10.1101/2022.07.25.501400 — microbiology — Posted on 2022-07-25
641 Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome
Wang, M.; Osborn, L. J.; Jain, S.; Meng, X.; Weakley, A.; Yan, J.; Massey, W.; Venkateshwari, V.; Horak, A. J.; Banerjee, R.; Allende, D. S.; Chan, R.; Hajjar, A.; Dimas, A.; Zhao, A.; Nagashima, K.; Cheng, A.; Higginbottom, S. K.; Brown, J. M.; Fischbach, M. A.
10.1101/2022.07.25.501461 — microbiology — Posted on 2022-07-25
643 A widely distributed gene cluster compensates for uricase loss in hominids
Liu, Y.; Jarman, J. B.; Low, Y. S.; Huang, S.; Chen, H.; Defeo, M. E.; Sekiba, K.; Hou, B.-H.; Ganesan, C.; Pao, A. C.; Gombar, S.; Dodd, D.
10.1101/2022.07.24.501321 — microbiology — Posted on 2022-07-25
644 Multivariate chemogenomic screening prioritizes new macrofilaricidal leads
Wheeler, N. J.; Ryan, K. T.; Gallo, K. J.; Henthorn, C. R.; Ericksen, S. S.; Chan, J. D.; Zamanian, M.
10.1101/2022.07.25.501423 — microbiology — Posted on 2022-07-25
648 "Sonohistology": Ultrasonographic Tissue Characterization in the Diagnosis of Hepatic Steatosis
de Oliveira Andrade, L. J.; Matos de Oliveira, L.; Ferreira Andrade, M. H.; Matos de Oliveira, G. C.
10.1101/2022.07.24.501305 — pathology — Posted on 2022-07-25
650 MINFLUX dissects the unimpeded walking of kinesin-1
Wolff, J. O.; Scheiderer, L.; Engelhardt, T.; Engelhardt, J.; Matthias, J.; Hell, S. W.
10.1101/2022.07.25.501426 — biophysics — Posted on 2022-07-25
652 Direct observation of motor protein stepping in living cells using MINFLUX
Deguchi, T.; Iwanski, M. K.; Schentarra, E.-M.; Heidebrecht, C.; Schmidt, L.; Heck, J.; Weihs, T.; Schnorrenberg, S.; Hoess, P.; Liu, S.; Chevyreva, V.; Noh, K.-M.; Kapitein, L. C.; Ries, J.
10.1101/2022.07.25.500391 — biophysics — Posted on 2022-07-25
653 Multi-Molecular Hyperspectral PRM-SRS Imaging
Shi, L.; Zhang, W.; Li, Y.; Fung, A. A.; Li, Z.; Jang, H.; Zha, H.; Chen, X.; Gao, F.; Wu, J. Y.; Sheng, H.; Yao, J.; Skowronska-Krawczyk, D.; Jain, S.
10.1101/2022.07.25.501472 — bioengineering — Posted on 2022-07-25
654 Stabilization of a Protein by a Single Halogen-Based Aromatic Amplifier
Hage, K. E.; Phillips, N. B.; Chen, Y.-S.; Dhayalan, B.; Whittaker, J.; Carr, K.; Whittaker, L.; Phillips, M. H.; Ismail-Beigi, F.; Meuwly, M.; Weiss, M. A.
10.1101/2022.07.25.501420 — biochemistry — Posted on 2022-07-25
656 Zinc transporter somatic gene mutations cause primary aldosteronism
Rege, J.; Nanba, K.; Bandulik, S.; Kosmann, C.; Blinder, A. R.; Vats, P.; Kumar-Sinha, C.; Lerario, A. M.; Else, T.; Yamazaki, Y.; Satoh, F.; Sasano, H.; Giordano, T. J.; Williams, T. A.; Reincke, M.; Turcu, A. F.; Udager, A. M.; Warth, R.; Rainey, W. E.
10.1101/2022.07.25.501443 — genetics — Posted on 2022-07-25
658 Monkey Pox Virus (MPXV): Phylogenomics, Host-Pathogen Interactome, and Mutational Cascade
Kumar, R.; Nagar, S.; Haider, S.; Sood, U.; Ponnusamy, K.; Dhingra, G. G.; Anand, S.; Dua, A.; Singh, M.; Senger, M.; Singh, I. K.; Lal, R.
10.1101/2022.07.25.501367 — microbiology — Posted on 2022-07-25
659 Metabolic activity organizes olfactory representations
Qian, W. W.; Wei, J. N.; Sanchez-Lengeling, B.; Lee, B. K.; Luo, Y.; Vlot, M.; Dechering, K.; Peng, J.; Gerkin, R. C.; Wiltschko, A. B.
10.1101/2022.07.21.500995 — neuroscience — Posted on 2022-07-25
660 Connectional architecture of the prefrontal cortex in the marmoset brain
Watakabe, A.; Skibbe, H.; Nakae, K.; Abe, H.; Ichinohe, N.; Rachmadi, M. F.; Wang, J.; Takaji, M.; Mizukami, H.; Woodward, A.; Gong, R.; Hata, J.; Okano, H.; Ishii, S.; Yamamori, T.
10.1101/2021.12.26.474213 — neuroscience — Posted on 2022-07-25
661 Laboratory evolution and polyploid SCRaMbLE reveal genomic plasticity to synthetic chromosome defects and rearrangements
Williams, T. C.; Kroukamp, H.; Xu, X.; Wightman, E. L. I.; Llorente, B.; Borneman, A. R.; Carpenter, A. C.; Van Wyk, N.; Espinosa, M. I.; Daniel, E. L.; Walker, R. S. K.; Cai, Y.; Nevalainen, H. K. M.; Curach, N. C.; Deveson, I. W.; Mercer, T. R.; Johnson, D. L.; Mitchell, L. A.; Bader, J. S.; Stracquadanio, G.; Boeke, J. D.; Goold, H. D.; Pretorius, I. S.; Paulsen, I. T.
10.1101/2022.07.22.501046 — synthetic biology — Posted on 2022-07-25
664 Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer
Alshehri, S.; Pavlovic, T.; Farsinejad, S.; Behboodi, P.; Quan, L.; Centeno, D.; Kung, D.; Rezler, M.; Lee, W.; Jasinski, P.; Dziabaszewska, E.; Nowak-Markwitz, E.; Kalyon, D.; Zaborowski, M.; Iwanicki, M.
10.1101/2022.01.30.478322 — cancer biology — Posted on 2022-07-25
670 Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity.
Flores-Santibanez, F.; Rennen, S.; Fernandez, D.; De Nolf, C.; Gaete, S.; Fuentes, C.; Moreno, C.; Figueroa, D.; Lladser, A.; Iwawaki, T.; Bono, M. R.; Janssens, S.; Osorio, F.
10.1101/2022.07.20.500838 — immunology — Posted on 2022-07-25
673 Genome edited colorectal cancer organoid models reveal distinct microRNA activity patterns across different mutation profiles
Villanueva, J. W.; Kwong, L.; Han, T.; Martinez, S. A.; Pan, F. C.; Shanahan, M. T.; Kanke, M.; Chen, S.; Dow, L. E.; Danko, C. G.; Sethupathy, P.
10.1101/2021.12.13.472432 — cancer biology — Posted on 2022-07-25
674 Genetic variability, including gene duplication and deletion, in early sequences from the 2022 European monkeypox outbreak
Jones, T. C.; Schneider, J.; Muehlemann, B.; Veith, T.; Beheim-Schwarzbach, J.; Tesch, J.; Schmidt, M.; Walper, F.; Bleicker, T.; Isner, C.; Pfaefflin, F.; Werner, R.; Corman, V. M.; Drosten, C.
10.1101/2022.07.23.501239 — bioinformatics — Posted on 2022-07-25
677 McAN: an ultrafast haplotype network construction algorithm
Li, L.; Xu, B.; Tian, D.; Li, C.; Li, N.; Wang, A.; Zhu, J.; Xue, Y.; Zhang, Z.; Bao, Y.; Zhao, W.; Song, S.
10.1101/2022.07.23.501111 — bioinformatics — Posted on 2022-07-25
678 Waning and boosting of functional humoral immunity to SARS-CoV-2
Tong, X.; McNamara, R. P.; Avendano, M. J.; Serrano, E. E.; Garcia-Salum, T.; Pardo-Roa, C.; Levican, J.; Poblete, E.; Salinas, E.; Munoz, A.; Riquelme, A.; Alter, G.; Medina, R. A.
10.1101/2022.07.22.501163 — immunology — Posted on 2022-07-25
681 Multi-omics integrated analysis reveals a specific phenotype of CD8+ T cell may contribute to immunothromosis via Th17 response in severe and critical COVID-19
Li, W.-X.; An, S.-Q.; Dai, S.-X.; Zhou, Z.-M.; Zeng, X.; Deng, G.-H.; Huang, Y.-Y.; Yin, Q.; Shen, L.-Y.; Xu, A.-Q.; Lin, Y.; Jiang, J.-J.; Wei, W.; Liang, H.; Guan, D.-G.; Zhou, C.
10.1101/2022.07.23.501235 — bioinformatics — Posted on 2022-07-25
683 Tracing the origin of Oriental beech stands across Western Europe and reporting hybridization with European beech - implications for assisted gene flow
Kurz, M.; Koelz, A.; Gorges, J.; Pablo Carmona, B.; Brang, P.; Vitasse, Y.; Kohler, M.; Rezzonico, F.; Smits, T. H. M.; Bauhus, J.; Rudow, A.; Hansen, O. K.; Vatanparast, M.; Sevik, H.; Zhelev, P.; Goemoery, D.; Paule, L.; Sperisen, C.; Csillery, K.
10.1101/2022.07.25.501368 — evolutionary biology — Posted on 2022-07-25
684 Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure
Bustamante, J.; Padilla, A.; White, B.; Auckland, L.; Busselman, R.; Collins, S.; Malcolm, E.; Wilson, B.; Saunders, A.; Hamer, S.; Tarleton, R. L.
10.1101/2022.07.25.501361 — microbiology — Posted on 2022-07-25
685 KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposis sarcoma studies
Tuohinto, K.; DiMaio, T. A.; Kiss, E. A.; Laakkonen, P.; Saharinen, P.; Karnezis, T.; Lagunoff, M.; Ojala, P. M.
10.1101/2022.07.25.501362 — microbiology — Posted on 2022-07-25
687 Robustness of the neuro-muscular octopaminergic system in the face of cold stress.
Kaya-Zeeb, S.; Delac, S.; Wolf, L.; Marante, A. L.; Scherf-Clavel, O.; Thamm, M.
10.1101/2022.07.25.501383 — physiology — Posted on 2022-07-25
688 Adipose tissue mitochondrial respiration in Atlantic salmon: implications for sex-dependent life-history variation
Prokkola, J. M.; Wagner, A.; Koskinen, E.; Debes, P. V.; House, A.; Asheim, E. R.; Primmer, C. R.; Pirinen, E.; Aykanat, T.
10.1101/2022.07.25.501389 — physiology — Posted on 2022-07-25
689 Enhanced epithelial to mesenchymal transition and chemoresistance in advanced Retinoblastoma tumors is driven by miR-181a
Suresh Babu, V.; Bisht, A.; Mallipatna, A.; SA, D.; Dudeja, G.; Kannan, R.; Shetty, R.; Heymans, S.; Guha, N.; Ghosh, A.
10.1101/2022.07.25.501381 — cancer biology — Posted on 2022-07-25
692 Deep embedded clustering by relevant scales and genome-wide association study in autism
Ueno, F.; Onuma, T.; Takahashi, I.; Ohseto, H.; Narita, A.; Obara, T.; Ishikuro, M.; Murakami, K.; Noda, A.; Matsuzaki, F.; Metoki, H.; Tamiya, G.; Kure, S.; Kuriyama, S.
10.1101/2022.07.25.500917 — genomics — Posted on 2022-07-25
693 Evolution of resilience against heat stress in a red-tide dinoflagellate
Dougan, K. E.; Deng, Z.-L.; Woehlbrand, L.; Reuse, C.; Bunk, B.; Chen, Y.; Hartlich, J.; Hiller, K.; John, U.; Kalvelage, J.; Mansky, J.; Neumann-Schaal, M.; Overmann, J.; Petersen, J.; Sanchez-Garcia, S.; Schmidt-Hohagen, K.; Shah, S.; Sproer, C.; Sztajer, H.; Wang, H.; Bhattacharya, D.; Rabus, R.; Jahn, D.; Chan, C. X.; Wagner-Doebler, I.
10.1101/2022.07.25.501386 — genomics — Posted on 2022-07-25
694 Reducing environmentally mediated transmission to moderate impacts of an emerging wildlife disease
Hoyt, J. R.; Parise, K. L.; DePue, J. E.; Kaarakka, H. M.; Redell, J. A.; Scullon, W. H.; O Reskie, R.; Foster, J. T.; Kilpatrick, A. M.; Langwig, K. E.; White, J. P.
10.1101/2022.07.25.501399 — ecology — Posted on 2022-07-25
695 Will Current Protected Areas Harbour Refugia for Threatened Arctic Vegetation Types until 2050?
Reji Chacko, M.; Goerens, A. K. A.; Oehri, J.; Plekhanova, E.; Schaepman-Strub, G.
10.1101/2021.04.28.441764 — ecology — Posted on 2022-07-25
696 Transient inhibition of translation improves long-term cardiac function after ischemia/reperfusion by attenuating the inflammatory response
Hofmann, C.; Serafin, A.; Schwerdt, O. M.; Younesi, F. S.; Sicklinger, F.; Meyer, I. S.; Malovrh, E.; Sandmann, C.; Juergensen, L.; Kamuf-Schenk, V.; Stroh, C.; Loewenthal, Z.; Rettel, M.; Stein, F.; Katus, H. A.; Jakobi, T.; Frey, N.; Leuschner, F.; Voelkers, M.
10.1101/2022.07.25.501397 — molecular biology — Posted on 2022-07-25
698 Rhizocarpon geographicum lichen discloses a highly diversified microbiota carrying antibiotic resistance and Persistent Organic Pollutants tolerance
Miral, A.; Kautsky, A.; Alves-Carvalho, S.; Cottret, L.; Guillerm-Erckelboudt, A.-Y.; Buguet, M.; Rouaud, I.; Tranchimand, S.; Tomasi, S.; Bartoli, C.
10.1101/2022.07.25.501376 — microbiology — Posted on 2022-07-25
700 Escherichia coli membrane microdomain SPFH protein HflC interacts with YajC and contributes to aminoglycoside and oxidative stress tolerance
Wessel, A. K.; Yoshii, Y.; Reder, A.; Boudjemaa, R.; Szczesna, M.; Betton, J.-M.; Bernal-Bayard, J.; Beloin, C.; Lopez, D.; Volker, U.; Ghigo, J.-M.
10.1101/2022.07.25.501378 — microbiology — Posted on 2022-07-25
701 CD3e-immunotoxin spares CD62L(lo) Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3e(hi) T cells.
Kim, S.; Shukla, R. K.; Yu, H.; Baek, A.; Cressman, S. G.; Golconda, S.; Lee, G.-E.; Choi, H.; Reneau, J. C.; Wang, Z.; Huang, C. A.; Liyanage, N. P. M.; Kim, S.
10.1101/2022.07.25.501205 — immunology — Posted on 2022-07-25
702 Neuronal Activity Alters Neuron to OPC Synapses
Moura, D. S.; Parvathaneni, A.; Sahagun, A.; Noguchi, H.; Tilton, I.; Brennan, E.; Brock, R. M.; Halladay, L. R.; Pleasure, S. J.; Cocas, L. A.
10.1101/2022.07.25.501254 — neuroscience — Posted on 2022-07-25
703 Single neurons in thalamus and subthalamic nucleus process cardiac and respiratory signals in humans
De Falco, E.; Solca, M.; Bernasconi, F.; Babo-Rebelo, M.; Young, N.; Sammartino, F.; Rezai, A.; Krishna, V.; Blanke, O.
10.1101/2022.07.25.501133 — neuroscience — Posted on 2022-07-25
704 Brainstem fMRI signaling of surprise across different types of deviant stimuli
Mazancieux, A.; Mauconduit, F.; Amadon, A.; de Gee, J. W.; Donner, T.; Meyniel, F.
10.1101/2022.07.25.501374 — neuroscience — Posted on 2022-07-25
706 Building artificial plant cell wall on lipid bilayer by assembling polysaccharides and engineered proteins
Notova, S.; Cannac, N.; Rabagliati, L.; Touzard, M.; Mante, J.; Navon, Y.; Coche-Guerante, L.; Lerouxel, O.; Heux, L.; Imberty, A.
10.1101/2022.07.25.501355 — synthetic biology — Posted on 2022-07-25
708 A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening
Kaufmann, J.; Blum, N. K.; Nagel, F.; Anna Schuler, A. S.; Drube, J.; Degenhart, C.; Engel, J.; Eickhoff, J. E.; Dasgupta, P.; Fritzwanker, S.; Guastadisegni, M.; Schulte, C.; Miess-Tanneberg, E.; Maric, H. M.; Spetea, M.; Kliewer, A.; Baumann, M.; Klebl, B.; Reinscheid, R. K.; Hoffmann, C.; Schulz, S.
10.1101/2022.07.25.501346 — pharmacology and toxicology — Posted on 2022-07-25
709 Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors
Goebel, L.; Kirschner, T.; Koska, S.; Rai, A.; Janning, P.; Maffini, S.; Vatheuer, H.; Czodrowski, P.; Goody, R. S.; Mueller, M. P.; Rauh, D.
10.1101/2022.07.25.501348 — cancer biology — Posted on 2022-07-25
710 Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT
Han, W.; Jin, M.; Liu, C.; Zhao, Q.; Wang, S.; Wang, Y.; Yin, Y.; Peng, C.; Wang, Y.; Cong, Y.
10.1101/2022.07.25.501395 — biophysics — Posted on 2022-07-25
711 Enhanced surface nano-analytics of transient biomolecular processes
Miller, A. M.; Chia, S.; Toprakcioglu, Z.; Hakala, T.; Schmid, R.; Feng, Y.; Kartanas, T.; Kamada, A.; Vendruscolo, M.; Ruggeri, F. S.; Knowles, T. P. J.
10.1101/2022.07.25.501379 — biophysics — Posted on 2022-07-25
714 Genetic architecture of creativity and extensive genetic overlap with psychiatric disorders revealed from genome-wide association analyses of 241,736 individuals
Kim, H.; Ahn, Y.; Yoon, J.; Jung, K.; Kim, S.; Shim, I.; Park, T. H.; Ko, H.; Jung, S.-H.; Kim, J.; Park, S.; Lee, D. J.; Choi, S.; Cha, S.; Kim, B.; Cho, M. Y.; Cho, H.; Kim, D. S.; Ihm, H. K.; Park, W.-Y.; Bakhshi, H.; O'Connell, K.; Andreassen, O.; Flint, J.; Kendler, K. S.; Myung, W.; Won, H.-H.
10.1101/2022.07.25.501322 — genomics — Posted on 2022-07-25
721 Identification of the onchocerciasis vector in the Kakoi-Koda focus of the Democratic Republic of Congo
Post, R. J.; Laudisoit, A.; Mandro, M.; Lakwo, T.; Laemmer, C.; Pfarr, K.; Hoerauf, A.; Tortosa, P.; Gomard, Y.; Ukety, T.; Mande, C.; Farovitch, L.; Amazigo, U.; Oguttu, D. W.; Bakajika, D.; Awaca, N.; Colebunders, R.
10.1101/2022.07.25.501358 — ecology — Posted on 2022-07-25
724 Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells
SASAKI, K.; Seita, Y.; Cheng, K.; McCarrey, J.; Yadu, N.; Cheeseman, I.; Bagwell, A.; Ross, C. N.; Santana-Toro, I.; Yen, L.-H.; Vargas, S.; Navara, C. S.; Hermann, B. P.
10.1101/2022.07.25.501382 — developmental biology — Posted on 2022-07-25
726 Myostatin gene deletion alters gut microbiota stimulating fast-twitch glycolytic muscle growth
Luo, Z.-B.; Han, S.; Yin, X.-J.; Liu, H.; Wang, J.; Xuan, M.; Hao, C.; Wang, D.; Liu, Y.; Chang, S.; Li, D.; Gao, K.; Li, H.; Quan, B.; Quan, L.-H.; Kang, J.-D.
10.1101/2022.07.24.501334 — microbiology — Posted on 2022-07-25
727 Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies
Zitzmann, C.; Dächert, C.; Schmid, B.; van der Schaar, H.; van Hemert, M.; Perelson, A. S.; van Kuppeveld, F.; Bartenschlager, R.; Binder, M.; Kaderali, L.
10.1101/2022.07.25.501353 — microbiology — Posted on 2022-07-25
730 Unbiased Classification of the Human Brain Proteome Resolves Distinct Clinical and Pathophysiological Subtypes of Cognitive Impairment
Higginbotham, L. A.; Carter, E. K.; Dammer, E. B.; Haque, R. U.; Johnson, E. C. B.; Duong, D.; Yin, L.; De Jager, P. L.; Bennett, D. A.; Lah, J. J.; Levey, A. I.; Seyfried, N. T.
10.1101/2022.07.22.501017 — neuroscience — Posted on 2022-07-25
733 Validation of manifold-based direct control for a brain-to-body neural bypass
Losanno, E.; Badi, M.; Roussinova, E.; Bogaard, A.; Delacombaz, M.; Shokur, S.; Micera, S.
10.1101/2022.07.25.501351 — bioengineering — Posted on 2022-07-25
735 Foxm1 drives cardiomyocyte proliferation in adult zebrafish after cardiac injury
Zuppo, D. A.; Missinato, M. A.; Santana-Santos, L.; Li, G.; Benos, P.; Tsang, M.
10.1101/2022.06.22.497073 — developmental biology — Posted on 2022-07-25
736 Mining the microbiota to identify gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis
Bianchimano, P.; Britton, G. J.; Wallach, D.; Smith, E.; Cox, L.; Liu, S.; Iwanowski, K.; Weiner, H.; Faith, J. J.; Clemente, J. C.; Tankou, S.
10.1101/2021.11.10.468120 — immunology — Posted on 2022-07-25
737 Correspondence between the layered structure of deep language models and temporal structure of natural language processing in the human brain
Goldstein, A.; Ham, E.; Nastase, S. A.; Zada, Z.; Dabush, A.; Bobbi Aubrey, B.; Schain, M.; Gazula, H.; Feder, A.; Doyle, W.; Devore, S.; Dugan, P.; Friedman, D.; Brenner, M.; Hassidim, A.; Devinsky, O.; Flinker, A.; Levy, O.; Hasson, U.
10.1101/2022.07.11.499562 — neuroscience — Posted on 2022-07-25
738 Regulation strategies for two-output biomolecular networks
Alexis, E.; Schulte, C. C. M.; Cardelli, L.; Papachristodoulou, A.
10.1101/2022.02.28.482258 — synthetic biology — Posted on 2022-07-25
740 Structural basis for Cas9 off-target activity
Pacesa, M.; Lin, C.-H.; Clery, A.; Saha, A.; Arantes, P. R.; Bargsten, K.; Irby, M. J.; Allain, F. H.; Palermo, G.; Cameron, P.; Donohoue, P. D.; Jinek, M.
10.1101/2021.11.18.469088 — biochemistry — Posted on 2022-07-25
741 The E3 ligase RNF115 regulates phagosome maturation and host response to bacterial infection
Bilkei-Gorzo, O.; Heunis, T.; Marin Rubio, J.-L.; Cianfanelli, F. R.; Raymond, B. B. A.; Inns, J.; Fabrikova, D.; Peltier, J.; Oakley, F.; Schmid, R.; Härtlova, A.; Trost, M.
10.1101/2021.07.13.452284 — biochemistry — Posted on 2022-07-25
743 Annexin A1 is a polarity cue that directs planar mitotic spindle orientation during mammalian epithelial morphogenesis
Fankhaenel, M.; Golestan Hashemi, F. S.; Mourao, L.; Lucas, E.; Hosawi, M. M.; Skipp, P.; Morin, X.; Scheele, C. L.; Elias, S.
10.1101/2021.07.28.454117 — cell biology — Posted on 2022-07-25
745 Neural systems underlying RDoC social constructs: An activation likelihood estimation meta-analysis
Lobo, R. P.; Bottenhorn, K. L.; Riedel, M. C.; Toma, A. I.; Hare, M. M.; Smith, D. D.; Moor, A. C.; Cowan, I. K.; Valdes, J. A.; Bartley, J. E.; Salo, T.; Boeving, E. R.; Pankey, B.; Sutherland, M. T.; Musser, E. D.; Laird, A. R.
10.1101/2022.04.04.487016 — neuroscience — Posted on 2022-07-25
746 Loss of genome maintenance accelerates podocyte damage
Braun, F.; Mandel, A. M.; Blomberg, L.; Wong, M. N.; Chatzinikolaou, G.; Nair, V.; Akbar-Hase, R. A.; Puelles, V. G.; McCown, P. J.; Haas, F.; Rahmatollahi, M.; Fermin, D.; Slaats, G.; Bork, T.; Schell, C.; Koehler, S.; Brinkkoetter, P.; Lindenmeyer, M. T.; Cohen, C.; Kann, M.; Bloch, W.; Sampson, M. G.; Dolle, M. E.; Kretzler, M.; Garinis, G. A.; Huber, T. B.; Schermer, B.; Benzing, T.; Schumacher, B.; Kurschat, C. E.
10.1101/2020.09.13.295303 — cell biology — Posted on 2022-07-25
747 Unidirectional recruitment is essential for viral latency
Lavi, I.; Bhattacharya, S.; Orgil, O.; Awase, A.; Avital, N.; Journo, G.; Gurevich, V.; Shamay, M.
10.1101/2021.10.10.463816 — microbiology — Posted on 2022-07-25
748 Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2
Ai, L.; Li, Y.; Zhou, L.; Zhang, H.; Yao, W.; Han, J.; Wu, J.; Wang, R.; Wang, W.; Xu, P.; Li, Z.; Wei, C.; Chen, H.; Liang, J.; Guo, M.; Huang, Z.; Wang, X.; Zhang, Z.; Xiang, W.; Lv, B.; Peng, P.; Zhang, S.; Ji, X.; Li, Z.; Luo, H.; Chen, J.; Lan, K.; Hu, Y.
10.1101/2022.02.10.479867 — immunology — Posted on 2022-07-25
751 Transcriptome responses of virus-transmitting aphid vectors are shaped by the host plant and the virus mode of transmission
Chesnais, Q.; Golyaev, V.; Velt, A.; Rustenholz, C.; Verdier, M.; Brault, V.; Pooggin, M. M.; Drucker, M.
10.1101/2022.07.18.500449 — plant biology — Posted on 2022-07-25
752 Stepwise recombination suppression around the mating-type locus in the fungus Schizothecium tetrasporum (Ascomycota, Sordariales)
Vittorelli, N.; Snirc, A.; Levert, E.; Gautier, V.; Lalanne, C.; De Filippo, E.; Rodriguez de la Vega, R. C.; Gladieux, P.; Guillou, S.; Zhang, Y.; Tejomurthula, S.; Grigoriev, I. V.; Debuchy, R.; Silar, P.; Giraud, T.; Hartmann, F.
10.1101/2022.07.20.500756 — evolutionary biology — Posted on 2022-07-25
755 The AI Neuropsychologist: Automatic scoring of memory deficits with deep learning
Langer, N.; Weber, M.; Hebling Vieira, B.; Strzelczyk, D.; Wolf, L.; Pedroni, A.; Heitz, J.; Schultheis, C.; Troendle, M.; Arango Lasprilla, J. C.; Rivera, D.; Scarpina, F.; Zhao, Q.; Leuthold, R.; Wehrle, F.; Jenni, O. G.; Brugger, P.; Zaehle, T.; Lorenz, R.; Zhang, C.
10.1101/2022.06.15.496291 — neuroscience — Posted on 2022-07-25
756 CellSium - Versatile Cell Simulator for Microcolony Ground Truth Generation
Sachs, C. C.; Ruzaeva, K.; Seiffarth, J.; Wiechert, W.; Berkels, B.; Noeh, K.
10.1101/2022.03.24.485611 — bioinformatics — Posted on 2022-07-25
757 Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury
Fang, A.; Wang, Y.; Guan, N.; Lin, L.; Guo, B.; Cai, W.; Chen, X.; Ye, J.; Abdelrahman, Z.; Li, X.; Zuo, Y.; Zheng, H.; Wu, Z.; Jin, S.; Xu, K.; Gu, X.; Yu, B.; Wang, X.
10.1101/2022.07.18.500400 — bioengineering — Posted on 2022-07-25
758 Structural variation turnovers and defective genomes: key drivers for the in vitro evolution of the large double-stranded DNA koi herpesvirus (KHV)
Fuandila, N. N.; Gosselin-Grenet, A.-S.; Tilak, M.-K.; Bergmann, S. M.; Escoubas, J.-M.; Klafack, S.; Lusiastuti, A. M.; Yuhana, M.; Fiston-Lavier, A.-S.; Avarre, J.-C.; Cherif, E.
10.1101/2022.03.10.483410 — genomics — Posted on 2022-07-25
759 MCRS1 modulates the heterogeneity of microtubule minus-end morphologies in mitotic spindles
Laguillo-Diego, A.; Kiewisz, R.; Marti-Gomez, C.; Baum, D.; Muller-Reichert, T.; Vernos, I.
10.1101/2022.06.03.494715 — cell biology — Posted on 2022-07-25
760 Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia
Goikolea, J.; Roussarie, J. P.; Gerenu, G.; Loera-Valencia, R.; Latorre-Leal, M.; Cedazo-Minguez, A.; Rodriguez-Rodriguez, P.; Maioli, S.
10.1101/2022.03.09.483648 — neuroscience — Posted on 2022-07-25
763 Unique Evolution of Antiviral Tetherin in Bats
Hayward, J. A.; Tachedjian, M.; Johnson, A.; Irving, A. T.; Gordon, T. B.; Cui, J.; Nicolas, A.; Smith, I.; Boyd, V.; Marsh, G. A.; Baker, M. L.; Wang, L.-F.; Tachedjian, G.
10.1101/2020.04.08.031203 — evolutionary biology — Posted on 2022-07-25
764 Cell cycle and temporal transcription factors regulate proliferation and neuronal diversity of dedifferentiation-derived neural stem cells
Cheng, L.; Veen, K.; Froldi, F.; Dong, Q.; Alvarez-Ochoa, E.; Nguyen, P.-K.; Harvey, K. F.; McMullen, J. P. D.; Marshall, O. J.; Jusuf, P. R.
10.1101/2022.07.24.501087 — developmental biology — Posted on 2022-07-24
766 Specific recognition and ubiquitination of slow-moving ribosomes by human CCR4-NOT
Absmeier, E.; Chandrasekaran, V.; O'Reilly, F. J.; Stowell, J. A.; Rappsilber, J.; Passmore, L. A.
10.1101/2022.07.24.501325 — molecular biology — Posted on 2022-07-24
767 Stiffness-dependent active wetting enables optimal collective cell durotaxis
Pallares, M. E.; Pi-Jauma, I.; Fortunato, I. C.; Grazu, V.; Gomez-Gonzalez, M.; Roca-Cusachs, P.; de la Fuente, J. M.; Alert, R.; Sunyer, R.; Casademunt, J.; Trepat, X.
10.1101/2022.07.24.501310 — biophysics — Posted on 2022-07-24
769 Single-nucleus ATAC-seq elucidates major modules of gene regulation in the development of non-alcoholic fatty liver disease
Takeuchi, F.; Liang, Y.-Q.; Shimizu-Furusawa, H.; Isono, M.; Ang, M. Y.; Mori, K.; Mori, T.; Kakazu, E.; Yoshio, S.; Kato, N.
10.1101/2022.07.12.499681 — genomics — Posted on 2022-07-24
770 Gene expression in African Americans and Latinos reveals ancestry-specific patterns of genetic architecture
Kachuri, L.; Mak, A. C. Y.; Hu, D.; Eng, C.; Huntsman, S.; Elhawary, J. R.; Gupta, N.; Gabriel, S.; Xiao, S.; Keys, K. L.; Oni-Orisan, A.; Rodriguez-Santana, J. R.; LeNoir, M. A.; Borrell, L. N.; Zaitlen, N. A.; Williams, L. K.; Gignoux, C. R.; Burchard, E. G.; Ziv, E.
10.1101/2021.08.19.456901 — genetics — Posted on 2022-07-24
771 DNA packaging via hierarchical chromatin structures revealed by live-cell superresolution 3D imaging
ZHENG, Y.; Ye, S.; Li, S.; Liu, C.; Luo, S.; Chen, Y.; Li, Y.; Huang, L.; Deng, S.; Chen, P.; Zhang, Y.; Ji, W.; Luo, R.; Li, G.; Yang, D.
10.1101/2022.06.22.497271 — cell biology — Posted on 2022-07-24
772 Mouse primary visual cortex neurons respond to the illusory ''darker than black'' in neon color spreading.
Saeedi, A.; Wang, K.; Nikpourian, G.; Bartels, A.; Totah, N. K.; Logothetis, N. K.; Watanabe, M.
10.1101/2022.07.24.501311 — neuroscience — Posted on 2022-07-24
773 Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins
Metzger, J. M.; Wang, Y.; Neuman, S. S.; Snow, K. J.; Murray, S. A.; Lutz, C. M.; Bondarenko, V.; Felton, J. A.; Gimse, K.; Xie, R.; Zhao, Y.; Flowers, M. T.; Simmons, H. A.; Roy, S.; Saha, K.; Levine, J.; Emborg, M. E.; Gong, S.
10.1101/2022.07.24.501299 — neuroscience — Posted on 2022-07-24
779 GeneVector: Identification of transcriptional programs using dense vector representations defined by mutual information.
Ceglia, N.; Sethna, Z.; Uhlitz, F.; Bojilova, V.; Rusk, N.; Burman, B.; Chow, A.; Salehi, S.; Kabeer, F.; Aparicio, S. H.; Greenbaum, B. D.; Shah, S. P.; McPherson, A.
10.1101/2022.04.22.487554 — bioinformatics — Posted on 2022-07-24
781 Dynamic changes in the niche and transcription trigger early murine and human pluripotent stem cell-derived liver organogenesis
Ogoke, O.; Guiggey, D.; Thompson, S.; Chiang, A.; Nguyen, T. H. A.; Berke, D.; Ott, C.; Kalinousky, A.; Shamul, C.; Chen, P.; Ross, S.; Chen, Z.; Srivastava, P.; Mahajan, S. D.; Zhao, R.; Gunawan, R.; Parashurama, N.
10.1101/2022.07.24.501313 — bioengineering — Posted on 2022-07-24
787 PERK-ATAD3A interaction protects mitochondrial proteins synthesis during ER stress
Hughes, D. T.; Brar, K. K.; Morris, J.; Subramanian, K.; Krishna, S.; Gao, F.; Rieder, L.-S.; Freeman, J. L.; Smith, H. L.; Jukes-Jones, R.; Nunnari, J.; Prudent, J.; Butcher, A. J.; Mallucci, G. R.
10.1101/2022.07.24.501280 — cell biology — Posted on 2022-07-24
788 Anti-apoptotic BH3-only proteins inhibit Bak
Ruehl, S.; Guy, C. S.; Li, Z.; Yang, M.; Moldoveanu, T.; Green, D. R.
10.1101/2022.07.24.499430 — cell biology — Posted on 2022-07-24
789 Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells.
Oltra, S. S.; Sin, L.; Colomo, S.; Perez-Lopez, M.; Molina-Crespo, A.; Choi, K.-H.; Martinez, L.; Morales, S.; Gonzalez-Paramos, C.; Orantes, A.; Soriano, M.; Hernandez, A.; Lluch, A.; Rojo, F.; Albanell, J.; Ko, J.-K.; Sarrio, D.; Moreno-Bueno, G.
10.1101/2022.07.24.501218 — molecular biology — Posted on 2022-07-24
790 Structural basis of a high-affinity antibody binding to glycoprotein region with consecutive glycosylation sites
Han, Y.; Niu, J.; Pan, D.; Feng, C.; Song, K.; Meng, B.; Westerlind, U.; Zhang, Y.; Liu, H.; Xu, L.; Zhou, D.
10.1101/2022.07.24.501275 — immunology — Posted on 2022-07-24
792 Closed-loop brain stimulation to reduce pathologic fear
Rodrigo, S. O.; Pedraza, L. K.; Barcsai, L.; Pejin, A.; Kozak, G.; Takeuchi, Y.; Lorincz, M. L.; Devinsky, O.; Buzsaki, G.; Berenyi, A.
10.1101/2022.07.24.501314 — neuroscience — Posted on 2022-07-24
795 Chromatin Remodeling in Patient-Derived Colorectal Cancer Models
Xiang, K.; Wang, E.; Rupprecht, G.; Mantyh, J.; Negrete, M.; Sanati, G.; Hsu, C.; Randon, P.; Dohlman, A.; Kretzschmar, K.; Giroux, N.; Ding, S.; Wang, L.; Prado, J.; Huang, Q.; Sundaramoorthy, P.; Xi, R.; McCall, S. J.; Wang, Z.; Kang, Y.; Kopetz, S.; Crawford, G.; Clevers, H.; Hsu, D.; Shen, X.
10.1101/2022.07.24.501300 — cancer biology — Posted on 2022-07-24
798 Top-Down Ion Mobility Separations of Isomeric Proteoforms
Berthias, F.; Thurman, H. A.; Wijegunawardena, G.; Wu, H.; Shvartsburg, A.; Jensen, O. N.
10.1101/2022.07.23.501273 — biochemistry — Posted on 2022-07-24
803 3D-MASNet: 3D Mixed-scale Asymmetric Convolutional Segmentation Network for 6-month-old Infant Brain MR Images
Zeng, Z.; Zhao, T.; Sun, L.; Zhang, Y.; Xia, M.; Liao, X.; Zhang, J.; Shen, D.; Wang, L.; He, Y.
10.1101/2021.05.23.445294 — neuroscience — Posted on 2022-07-24
804 An intestinal sphingolipid promotes neuronal health across generations
Wang, W.; Sherry, T.; Cheng, X.; Fan, Q.; Cornell, R.; Liu, J.; Xiao, Z.; Pocock, R.
10.1101/2022.07.24.501274 — neuroscience — Posted on 2022-07-24
805 Immunity priming uncouples the growth-defense tradeoff in tomato
Schneider, A.; Leibman-Markus, M.; Gupta, R.; Marash, I.; Rav-David, D.; Elad, Y.; Bar, M.
10.1101/2022.07.24.501304 — plant biology — Posted on 2022-07-24
806 A survey of transcriptomic datasets identifies ABA-responsive factors as regulators of photomorphogenesis in Arabidopsis
Stafen, C. F.; Souza, I.; de Oliveira, B. H.; de Oliveira-Busatto, L. A.; Dalmolin, R. J. S.; Sanchez, O. L.; Maraschin, F. d. S.
10.1101/2022.07.24.501316 — plant biology — Posted on 2022-07-24
808 Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism
Langley, C.; Tatsis, E. E.; Hong, B.; Nakamura, Y.; Paetz, C.; Stevenson, C. E. M.; Basquin, J.; Lawson, D. M.; Caputi, L.; O'Connor, S. E.
10.1101/2022.07.24.501124 — biochemistry — Posted on 2022-07-24
809 Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors
Replogle, J. M.; Bonnar, J. L.; Pogson, A. N.; Liem, C. R.; Maier, N. K.; Ding, Y.; Russell, B. J.; Wang, X.; Leng, K.; Guna, A.; Norman, T. M.; Pak, R. A.; Ramos, D. M.; Ward, M. E.; Gilbert, L. A.; Kampmann, M.; Weissman, J. S.; Jost, M.
10.1101/2022.07.13.499814 — genomics — Posted on 2022-07-24
811 Establishment and Characterization of Novel Canine Organoids with Organ-Specific Physiological Similarity
Zdyrski, C.; Gabriel, V.; Ospina, O. E.; Wickham, H.; Sahoo, D. K.; Dao, K.; Aguilar Meza, L. S.; Bedos, L.; Honold, S.; Pineyro, P.; Mochel, J. P.; Allenspach, K.
10.1101/2022.07.15.500059 — genetics — Posted on 2022-07-24
812 Multi-cellular communities are perturbed in the aging human brain and with Alzheimer's disease
Cain, A.; Taga, M.; McCabe, C.; Green, G.; Hekselman, I.; White, C. C.; Lee, D. I.; Gaur, P.; Rozenblatt-Rosen, O.; Zhang, F.; Yeger-Lotem, E.; Bennett, D. A.; Yang, H.-S.; Regev, A.; Menon, V.; Habib, N.; De Jager, P.
10.1101/2020.12.22.424084 — neuroscience — Posted on 2022-07-24
814 The gradient model of brain organization in decisions involving 'empathy for pain'
Labek, K.; Sittenberger, E.; Kienhoefer, V.; Rabl, L.; Messina, I.; Schurz, M.; Stingl, J. C.; Viviani, R.
10.1101/2021.11.28.470235 — neuroscience — Posted on 2022-07-24
817 CRISPR-Detector: Fast and Accurate Detection, Visualization, and Annotation of Genome Wide Mutations Induced by Gene Editing Events
Huang, L.; Wang, D.; Chen, H.; Hu, J.; Dai, X.; Liu, C.; Li, A.; Shen, X.; Qi, C.; Sun, H.; Zhang, D.; Chen, T.; Jiang, Y.
10.1101/2022.02.16.480781 — bioinformatics — Posted on 2022-07-24
827 Probabilistic embedding, clustering, and alignment for integrating spatial transcriptomics data with PRECAST
Liu, W.; Liao, X.; Luo, Z.; Yang, Y.; Lau, M. C.; Jiao, Y.; Shi, X.; Zhai, W.; Ji, H.; Yeong, J.; Liu, J.
10.1101/2022.06.26.497672 — genomics — Posted on 2022-07-24
829 Mitotic H3K9ac is controlled by phase-specific activity of HDAC2, HDAC3 and SIRT1
Gandhi, S.; Mitterhoff, R.; Rapoport, R.; Farago, M.; Greenberg, A.; Hodge, L.; Eden, S.; Benner, C.; Goren, A.; Simon, I.
10.1101/2021.03.08.434337 — cell biology — Posted on 2022-07-24
830 Identification of a microbial sub-community from the feral chicken gut that reduces Salmonella colonization and improves gut health in a gnotobiotic chicken model.
Wongkuna, S.; Kumar, R.; Ghimire, S.; Mattiello, S.; Maji, A.; Ambat, A.; Antony, L.; Chankhamhaengdecha, S.; Janvilisri, T.; Nelson, E.; Doerner, K.; Behr, M.; Scaria, J.
10.1101/2022.07.23.501241 — microbiology — Posted on 2022-07-24
832 Phosphorylation Determines Whether Neuroligin-3 is at Excitatory or Inhibitory Synapses in Different Regions of the Brain
Altas, B.; Tuffy, L. P.; Patrizi, A.; Dimova, K.; Soykan, T.; Romanowski, A. J.; Robertson, C. D.; Khim, S. N.; Bunce, G. W.; Ambrozkiewicz, M. C.; Yagensky, O.; Krueger-Burg, D.; Hammer, M.; Hsiao, H.-H.; Laskowski, P. R.; Dyck, L.; Sassoe-Pognetto, M.; Chua, J. J. E.; Urlaub, H.; Jahn, O.; Brose, N.; Poulopoulos, A.
10.1101/2022.07.23.501257 — neuroscience — Posted on 2022-07-24
838 Hydrogel Assisted Double Molding of 3D-Print Enables Prestress Regulation of Micro-Heart Muscle Physiology
Simmons, D. W.; Shuftan, D. R.; Guo, J.; Oguntuyo, K.; Ramahdita, G.; Munsell, M. K.; Kandalaft, B.; Pear, M.; Huebsch, N.
10.1101/2022.07.23.501265 — bioengineering — Posted on 2022-07-24
840 FHL5 controls vascular disease-associated gene programs in smooth muscle cells
Wong, D.; Auguste, G.; Lino Cardenas, C. L.; Turner, A. W.; Chen, Y.; Ma, L.; Perry, R. N.; Aherrahrou, R.; Kuppusamy, M.; Yang, C.; Mosquera, J. V.; Dube, C. J.; Khan, M. D.; Palmore, M.; Kavousi, M.; Peyser, P. A.; Matic, L.; Hedin, U.; Manichaikul, A.; Sonkusare, S. K.; Civelek, M.; Kovacic, J. C.; Bjorkegren, J. L. M.; Malhotra, R.; Miller, C. L.
10.1101/2022.07.23.501247 — genomics — Posted on 2022-07-23
841 Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein mediated neurodegeneration
Yu, M.; Ye, H.; De-Paula, R. B.; Mangleburg, C. G.; Wu, T.; Li, Y.; Duong, D.; Allen, G. I.; Seyfried, N. T.; Al-Ramahi, I.; Botas, J.; Shulman, J. M.
10.1101/2022.07.23.501240 — genetics — Posted on 2022-07-24
846 Identification of pre-existing microbiome and metabolic vulnerabilities to escalation of oxycodone self-administration and identification of a causal role of short-chain fatty acids in addiction-like behaviors.
Simpson, S.; Kimbrough, A.; Peters, G.; Wellmeyer, E.; Mclellan, R.; Walker, N.; Jia, H.; Hu, S.; Iyer, M.; Sathish, V.; Sedighim, S.; Kallupi, M.; Brennan, M.; Maturin, L.; Hughes, T.; Xie, T.; Espinoza, V.; Carrette, L.; Smith, L. C.; Seaman, J.; Solberg-Woods, L.; Palmer, A.; de Guglielmo, G.; George, O.
10.1101/2022.07.23.501268 — neuroscience — Posted on 2022-07-23
847 Laboratory evolution and polyploid SCRaMbLE reveal genomic plasticity to synthetic chromosome defects and rearrangements
Williams, T. C.; Kroukamp, H.; Xu, X.; Wightman, E. L. I.; Llorente, B.; Borneman, A. R.; Carpenter, A. C.; Van Wyk, N.; Espinosa, M. I.; Daniel, E. L.; Walker, R. S. K.; Cai, Y.; Nevalainen, H. K. M.; Curach, N. C.; Deveson, I. W.; Mercer, T. R.; Johnson, D. L.; Mitchell, L. A.; Bader, J. S.; Stracquadanio, G.; Boeke, J. D.; Goold, H. D.; Pretorius, I. S.; Paulsen, I. T.
10.1101/2022.07.22.501046 — synthetic biology — Posted on 2022-07-23
849 Body-plan reorganization in a sponge correlates with microbiome change
Vargas, S.; Leiva, L.; Eitel, M.; Curdt, F.; Rohde, S.; Arnold, C.; Nickel, M.; Schupp, P.; Orsi, W. D.; Adamska, M.; Woerheide, G.
10.1101/2022.07.22.501172 — genomics — Posted on 2022-07-23
850 Co-opted Genes of Algal Origin Protect C. elegans against Cyanogenic Toxins
Wang, B.; Pandey, T.; Long, Y.; Delgado-Rodriguez, S.; Daugherty, M. D.; Ma, D. K.
10.1101/2022.07.06.498920 — genetics — Posted on 2022-07-23
852 Sampling bias and the robustness of ecological metrics for plant-damage-type association networks
Swain, A.; Azevedo-Schmidt, L. E.; Maccracken, S. A.; Currano, E. D.; Dunne, J.; Labandeira, C. C.; Fagan, W. F.
10.1101/2022.07.23.501238 — ecology — Posted on 2022-07-23
853 Disaggregation as an interaction mechanism among intestinal bacteria
Sundarraman, D.; Smith, T. J.; Kast, J. V. Z.; Guillemin, K.; Parthasarathy, R.
10.1101/2022.07.22.501191 — microbiology — Posted on 2022-07-23
855 Identification of individual differences in response to methadone, buprenorphine, and naltrexone in animal models of opioid use disorder
Kallupi, M.; de Guglielmo, G.; Conlisk, D.; Brennan, M.; Tieu, L.; Sedighim, S.; Boomhower, B.; Smith, L. C.; Shankar, K.; Carrette, L. L.; Simpson, S.; Avelar, A.; Maturin, L.; Martinez, A.; Qiao, R.; Dirik, S.; Crook, C.; Bonnet-Zahedi, S.; Iyer, M. R.; Blucher, C. E.; Fannon, M. J.; Solberg Woods, L. C.; Palmer, A. A.; George, O.
10.1101/2022.07.23.501217 — neuroscience — Posted on 2022-07-23
857 Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance
Jiang, K.; Lim, S. B.; Xiao, J.; Jokhun, D. S.; Shang, M.; Song, X.; Zhang, P.; Liang, L.; Low, B. C.; Shivashankar, G. V.; Lim, C. T.
10.1101/2022.07.22.501206 — cancer biology — Posted on 2022-07-23
867 Unified Tumor Growth Mechanisms from Multimodel Inference and Dataset Integration
Beik, S. P.; Harris, L. A.; Kochen, M. A.; Sage, J.; Quaranta, V.; Lopez, C. F.
10.1101/2022.07.22.500696 — systems biology — Posted on 2022-07-23
868 Temporal regulation of TAK1 to counteract muscular dystrophy
Roy, A.; Koike, T. E.; Joshi, A. S.; Tomaz da Silva, M.; Mathukumalli, K.; Wu, M.; Kumar, A.
10.1101/2022.07.22.501199 — physiology — Posted on 2022-07-23
869 Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma
Pan, Z.; Chang, S.; Chen, S.; Zhao, D.; Zou, Z.; Dai, L.; Hou, Y.; Zhang, Q.; Yang, Y.; Chen, Z.; Zhang, W.; Zhao, Y.
10.1101/2022.07.22.501084 — cancer biology — Posted on 2022-07-23
870 Fully Automated Multi-Grid Cryo-EM Screening using Smart Leginon
Cheng, A.; Kim, P.; Kuang, H.; Mendez, J. H.; Chua, E. Y. D.; Maruthi, K.; Wei, H.; Sawh, A.; Aragon, M. F.; Serbynovskyi, V.; Neselu, K.; Eng, E. T.; Potter, C. S.; Carragher, B.; Bepler, T.; Noble, A. J.
10.1101/2022.07.23.501225 — biophysics — Posted on 2022-07-23
874 In silico-based screening for natural products structural analogs as new drugs candidate against leishmaniasis
Barazorda Ccahuana, H. L.; Goyzueta Mamani, L. D.; Candia Puma, M. A.; Freitas, C.; de Sousa Vieria Tavares, G.; Pagliara Lage, D.; Ferraz Coelho, E. A.; Chavez Fumagalli, M. A.
10.1101/2022.07.22.501189 — bioinformatics — Posted on 2022-07-23
875 Drug repositioning with gender perspective focused on Adverse Drug Reactions
Otero Carrasco, B.; Perez Perez, A.; Menasalvas Ruiz, E.; Caraca-Valente Hernandez, J. P.; Prieto Santamaria, L.; Rodriguez-Gonzalez, A.
10.1101/2022.07.22.501091 — bioinformatics — Posted on 2022-07-23
877 Wireless Measurements Using Electrical Impedance Spectroscopy to Monitor Fracture Healing
Fukase, N.; Duke, V. R.; Lin, M. C.; Stake, I. K.; Huard, M.; Huard, J.; Marmor, M. T.; Maharbiz, M. M.; Ehrhart, N. P.; Bahney, C. S.; Herfat, S. T.
10.1101/2022.07.23.501237 — bioengineering — Posted on 2022-07-23
879 Mining the human gut microbiome identifies mycobacterial D-arabinan degrading enzymes
Al-Jourani, O.; Benedict, S. T.; Ross, J.; Layton, A. J.; van der Peet, P.; Marando, V.; Bailey, N. P.; Heunis, T.; Manion, J.; Mensitieri, F.; Franklin, A.; Abellon-Ruiz, J.; Oram, S. L.; Parsons, L.; Cartmell, A.; Wright, G. S.; Basle, A.; Trost, M.; Henrissat, B.; Munoz-Munoz, J.; Hirt, R. P.; Keissling, L. L.; Lovering, A. L.; Williams, S. J.; Lowe, E. C.; Moynihan, P. J.
10.1101/2022.07.22.500997 — biochemistry — Posted on 2022-07-23
885 Evaluation of the nemabiome approach for the study of equine strongylid communities
Courtot, E.; Boisseau, M.; Dhorne-Pollet, S.; Serreau, D.; Gesbert, A.; Reigner, F.; Basiaga, M.; Kuzmina, T.; Lluch, J.; Annonay, G.; Kuchly, C.; Diekmann, I.; Krücken, J.; von Samson-Himmelstjerna, G.; Mach, N.; Salle, G.
10.1101/2022.07.22.501098 — ecology — Posted on 2022-07-23
890 A large-scale brain network of species-specific dynamic human body perception
Li, B.; Poyo Solanas, M.; Marrazzo, G.; Raman, R.; Taubert, N.; Giese, M.; Vogels, R.; de Gelder, B.
10.1101/2022.07.22.501117 — neuroscience — Posted on 2022-07-23
891 FT-GO: a multiplex fluorescent tyramide signal amplification system for histochemical analysis
Yamauchi, K.; Okamoto, S.; Ishida, Y.; Konno, K.; Hoshino, K.; Furuta, T.; Takahashi, M.; Koike, M.; Isa, K.; Watanabe, M.; Isa, T.; Hioki, H.
10.1101/2022.07.22.501050 — neuroscience — Posted on 2022-07-23
895 Suboptimal phenotypic reliability impedes reproducible human neuroscience
Nikolaidis, A.; Chen, A. A.; He, X.; Shinohara, R.; Vogelstein, J.; Milham, M.; Shou, H.
10.1101/2022.07.22.501193 — neuroscience — Posted on 2022-07-23
897 THINGS-data: A multimodal collection of large-scale datasets for investigating object representations in brain and behavior
Hebart, M. N.; Contier, O.; Teichmann, L.; Rockter, A.; Zheng, C. Y.; Kidder, A.; Corriveau, A.; Vaziri-Pashkam, M.; Baker, C. I.
10.1101/2022.07.22.501123 — neuroscience — Posted on 2022-07-23
899 Longitudinal in vivo monitoring of axonal integrity after brain injury
Chornyy, S.; Borovicka, J. A.; Patel, D.; Shin, M.-K.; Vazquez-Rosa, E.; Miller, E.; Wilson, B.; Piper, A. A.; Dana, H.
10.1101/2022.07.22.501178 — neuroscience — Posted on 2022-07-23
901 Brain fingerprint is based on the aperiodic, scale-free, neuronal activity
Sorrentino, P.; Troisi-Lopez, E.; Romano, A.; Sorrentino, G.; Jirsa, V.
10.1101/2022.07.23.501228 — neuroscience — Posted on 2022-07-23
902 Displacement experiments provide evidence for path integration in Drosophila
Titova, A. V.; Kau, B. E.; Tibor, S.; Mach, J.; Vo Doan, T. T.; Wittlinger, M.; Straw, A. D.
10.1101/2022.07.22.501185 — neuroscience — Posted on 2022-07-23
905 Age associated DNA methylation changes in Xenopus frogs
Morselli, M.; Bennett, R.; Shaidani, N.-I.; Horb, M.; Pellegrini, M.; Peshkin, L.
10.1101/2022.07.22.500491 — systems biology — Posted on 2022-07-23
907 Laboratory evolution and polyploid SCRaMbLE reveal genomic plasticity to synthetic chromosome defects and rearrangements
Williams, T. C.; Kroukamp, H.; Xu, X.; Wightman, E. L. I.; Llorente, B.; Borneman, A. R.; Carpenter, A. C.; Van Wyk, N.; Espinosa, M. I.; Daniel, E. L.; Walker, R. S. K.; Cai, Y.; Nevalainen, H. K. M.; Curach, N. C.; Deveson, I. W.; Mercer, T. R.; Johnson, D. L.; Mitchell, L. A.; Bader, J. S.; Stracquadanio, G.; Boeke, J. D.; Goold, H. D.; Pretorius, I. S.; Paulsen, I. T.
10.1101/2022.07.22.501046 — synthetic biology — Posted on 2022-07-23
908 Novel metabolic role for CD47 in pancreatic β-cell insulin secretion and islet transplant outcomes
Ghimire, K.; Kale, A.; Li, J.; Julovi, S. M.; O'Connell, P.; Grey, S. T.; Hawthorne, W. J.; Gunton, J. E.; Rogers, N. M.
10.1101/2022.07.22.501201 — physiology — Posted on 2022-07-23
912 Novel kinome profiling technology reveals drug treatment is patient and 2D/3D model dependent in GBM
Fabro, F.; Kannegieter, N. M.; de Graaf, E. L.; Queiroz, K.; Lamfers, M. L. M.; Ressa, A.; Leenstra, S.
10.1101/2022.07.22.499106 — cancer biology — Posted on 2022-07-23
913 PD-L1ATTAC mice reveal the potential of targeting PD-L1 expressing cells in cancer therapy
Fueyo-Marcos, E.; Fustero-Torre, C.; Anton, M. E.; Al-Shahrour, F.; Fernandez-Capetillo, O.; Murga, M.
10.1101/2022.07.22.501095 — cancer biology — Posted on 2022-07-23
914 p53 restoration in small cell lung cancer identifies a latent Cyclophilin-dependent necrosis mechanism
Acosta, J.; Li, Q.; Freebrug, N. F.; Murali, N.; Grothusen, G. P.; Cicchini, M.; Mai, H.; Gladstein, A. C.; Adler, K. M.; Doerig, K. R.; Li, J.; Ruiz-Torres, M.; Manning, K. L.; Stanger, B.; Busino, L.; Wan, L.; Feldser, D. M.
10.1101/2022.07.22.501202 — cancer biology — Posted on 2022-07-23
915 In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma
Fan, J. J.; Wang, X.; Erickson, A. W.; Skowron, P.; Wang, X.; Chen, X.; Shan, G.; Bahrampour, S.; Xiong, Y.; Dong, W.; Abeysundara, N.; Francisco, M. A.; Pusong, R. J.; Suarez, R. A.; Farooq, H.; Holgado, B. L.; Wu, X.; Daniels, C.; Dupuy, A. J.; Cadinanos, J.; Bradley, A.; Bagchi, A.; Moriarity, B. S.; Largaespada, D. A.; Morrissy, A. S.; Ramaswamy, V.; Mack, S. C.; Garzia, L.; Dirks, P. B.; Wanggou, S.; Li, X.; Sun, Y.; Taylor, M. D.; Huang, X.
10.1101/2022.07.23.501234 — cancer biology — Posted on 2022-07-23
918 MS2Query: Reliable and Scalable MS2 Mass Spectral-based Analogue Search
de Jonge, N. F.; Louwen, J. R.; Chekmeneva, E.; Camuzeaux, S.; Jansen, R. S.; Vermeir, F. J.; Huber, F.; van der Hooft, J. J. J.
10.1101/2022.07.22.501125 — bioinformatics — Posted on 2022-07-23
922 Multimodal electrocorticogram active electrode array based on zinc oxide-thin film transistors
Zhang, F.; Zhang, L.; Xia, J.; Zhao, W.; Dong, S.; Ye, Z.; Pan, G.; Luo, J.; Zhang, S.
10.1101/2022.07.22.500376 — bioengineering — Posted on 2022-07-23
926 Harnessing machine translation methods for sequence alignment
Dotan, E.; Belinkov, Y.; Avram, O.; Wygoda, E.; Ecker, N.; Alburquerque, M.; Keren, O.; Loewenthal, G.; Pupko, T.
10.1101/2022.07.22.501063 — evolutionary biology — Posted on 2022-07-23
932 Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease
Jafari, N.; Chen, A.; Kolla, M.; Pompa, I. R.; Qiu, Y.; Yu, R.; Llevenes, P.; Ennis, C. S.; Mori, J.; Mahdaviani, K.; Halpin, M.; Gignac, G. A.; Heaphy, C. M.; Monti, S.; Denis, G. V.
10.1101/2022.02.01.478722 — cancer biology — Posted on 2022-07-23
933 Spatial scenario of tropical deforestation and carbon emissions for the 21st century
Vieilledent, G.; Vancutsem, C.; Bourgoin, C.; Ploton, P.; Achard, F.; Verley, P.
10.1101/2022.03.22.485306 — ecology — Posted on 2022-07-23
936 Semi-automated protocol to quantify and characterize fluorescent three-dimensional vascular images
Xie, D. F.; Crouzet, C.; Lopresti, K.; Wang, Y.; Robinson, C.; Jones, W.; Muqolli, F.; Fang, C.; Cribbs, D. H.; Fisher, M.; Choi, B.
10.1101/2022.05.05.490827 — bioengineering — Posted on 2022-07-23
942 ZAXINONE SYNTHASE 2 regulates growth and arbuscular mycorrhizal symbiosis in rice
Ablazov, A.; Votta, C.; Fiorilli, V.; Wang, J. Y.; Aljedaani, F.; Jamil, M.; Balakrishna, A.; Balestrini, R.; Liew, K. X.; Rajan, C.; Berqdar, L.; Blilou, I.; Lanfranco, L.; Al-Babili, S.
10.1101/2022.07.21.501002 — plant biology — Posted on 2022-07-23
943 Molecular basis for the enzymatic macrocyclization of multiply backbone N-methylated peptides
Matabaro, E.; Song, H.; Gherlone, F.; Sonderegger, L.; Giltrap, A.; Liver, S.; Gossert, A.; Künzler, M.; Naismith, J. H.
10.1101/2022.07.21.500988 — biochemistry — Posted on 2022-07-23
944 Oxytocin receptor is not required for social attachment in prairie voles
Berendzen, K. M.; Sharma, R.; Alvarado, M.; Wei, Y.; Rogers, F. D.; Seelke, A.; Simmons, T. C.; Bond, J.; Larios, R. D.; Sherman, M.; Parthasarathy, S.; Espineda, I.; Knoedler, J. R.; Beery, A.; Bales, K. L.; Shah, N. M.; Manoli, D. S.
10.1101/2022.07.22.501192 — animal behavior and cognition — Posted on 2022-07-23
949 Adiponectin Promotes Glucose-Sensitive Insulin Secretion and Prevents β-Cell Damage by Obesity
Munhoz, A. C.; Serna, J. D. C.; Vilas-Boas, E. A.; Caldeira da Silva, C. C.; dos Santos, T. G.; Martins, V. R.; Kowaltowski, A. J.
10.1101/2022.07.22.501128 — biochemistry — Posted on 2022-07-22
950 The chromatin landscape of the euryarchaeon Haloferax volcanii
Marinov, G. K.; Bagdatli, S. T.; Wu, T.; He, C.; Kundaje, A.; Greenleaf, W.
10.1101/2022.07.22.501187 — genomics — Posted on 2022-07-22
952 Carbon ion irradiation plus CTLA4 blockade elicits therapeutic immune responses in a murine tumor model
Hartmann, L.; Osen, W.; Eichmüller, O. L.; Kordass, T.; Furkel, J.; Dickes, E.; Reid, C.; Debus, J.; Brons, S.; Abdollahi, A.; Moustafa, M.; Rieken, S.; Eichmüller, S. B.
10.1101/2022.07.22.500608 — immunology — Posted on 2022-07-22
953 Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice.
Thompson, D.; Mahmood, S.; Morrice, N.; Kamli-Salino, S.; Dekeryte, R.; Hoffmann, P.; Doherty, M. K.; Whitfield, P. D.; Delibegovic, M.; Mody, N.
10.1101/2022.07.22.500933 — physiology — Posted on 2022-07-22
955 A novel biopolymer synergizes type I IFN and IL-1β production through STING
Hoover, A. R.; Liu, K.; Lam, S. S. K.; Wong, C. F.; Medcalf, A. D.; Sun, X.-H.; Hode, T.; Alleruzzo, L.; Furrer, C.; Valerio, T. I.; Chen, W. R.
10.1101/2022.07.22.501157 — cancer biology — Posted on 2022-07-22
956 Combined scattering, interferometry and fluorescence oblique illumination for live cell nanoscale imaging
Zheng, Y.; Lim, Y. J.; Lin, H.; Xu, T.; Longbottom, C.; Delghingaro-Augusto, V.; Thong, Y. L.; Parish, C.; Gardiner, E. E.; Lee, W. M.
10.1101/2022.07.22.501104 — biophysics — Posted on 2022-07-22
957 Benchmarking long-read RNA-sequencing analysis tools using in silico mixtures
Dong, X.; Du, M. R. M.; Gouil, Q.; Tian, L.; Baldoni, P. L.; Smyth, G. K.; Amarasinghe, S. L.; Law, C. W.; Ritchie, M. E.
10.1101/2022.07.22.501076 — bioinformatics — Posted on 2022-07-22
959 Dynamic in vivo mapping of the methylproteome using a chemoenzymatic approach
Farhi, J.; Jones, R. B.; Verma, A. K.; Parwani, K. K.; Emenike, B.; Tang, K.-C.; Bagchi, P.; Raj, M.; Spangle, J.
10.1101/2022.07.22.501130 — biochemistry — Posted on 2022-07-22
960 Circulating extracellular vesicles in lung cancer patients are not enriched in tumor-derived DNA fragments as revealed by whole genome sequencing.
Moldovan, N.; Verkuijlen, S.; van der Pol, Y.; Bosch, L.; van Weering, J. R. T.; Bahce, I.; Pegtel, D. M.; Mouliere, F.
10.1101/2022.07.22.501161 — genomics — Posted on 2022-07-22
961 Large-scale in vivo CRISPR screens identify SAGA complex members as a key regulators of HSC lineage commitment and aging
Haney, M. S.; Shankar, A.; Hsu, I.; Miyauchi, M.; Palovics, R.; Khoo, H. M.; Igarashi, K. J.; Bhadury, J.; Munson, C.; Mack, P. K.; Tan, T.-K.; Wyss-Coray, T.; Nakauchi, H.; Wilkinson, A. C.
10.1101/2022.07.22.501030 — genetics — Posted on 2022-07-22
963 Exosome secretion kinetics are controlled by temperature
Mahmood, A.; Weisgerber, A. W.; Otruba, Z.; Palay, M. D.; Nguyen, M. T.; Bills, B. L.; Knowles, M. K.
10.1101/2022.07.22.501177 — cell biology — Posted on 2022-07-22
964 Analysis of the mechanism of castor tolerance to Cd metal based on proteomics and metabolomics
Zhao, H.; Zhao, Y.; Luo, R.; Li, G.; Di, j.; Wen, Q.; Liang, X.; Yin, M.; Wen, Y.; Wang, Z.; Huang, F.
10.1101/2022.07.22.501085 — molecular biology — Posted on 2022-07-22
966 Autonomous Remotely Controlled Closed System Transgenic Cell Technologies Robot: CRISPR.BOT
Erkek, F.; Gulden, G.; Sert, B.; Yilmaz, M. C.; Odabas, S. P.; Bal, E.; Yelgen, G.; Teymur, T.; Ay, Y.; Dogdu, S.; Tiryaki, N. N.; Baran, B.; Gelsin, B.; Araz, H.; Cavrar, I.; Tastan, C.
10.1101/2022.07.22.497959 — molecular biology — Posted on 2022-07-22
968 PD-1 and CTLA-4 exert additive control of effector regulatory T cells
Perry, J. A.; Lanzar, Z.; Clark, J. T.; Hart, A. P.; Douglas, B. B.; Shallberg, L.; O'Dea, K.; Christian, D. A.; Hunter, C. A.
10.1101/2022.07.22.501159 — immunology — Posted on 2022-07-22
969 Remodeling of Il4-Il13-Il5 locus underlies selective gene expression
Nagashima, H.; Petermann, F.; Pekowska, A.; Chaitankar, V.; Kanno, Y.; O'Shea, J. J.
10.1101/2022.07.22.501024 — immunology — Posted on 2022-07-22
970 Posttranslational modifications of the DUX4 protein impact toxic function
Knox, R. N.; Eidahl, J. O.; Wallace, L.; Choudury, S.; Rashnonejad, A.; Saad, N. Y.; Hoover, M. E.; Zhang, L.; Branson, O. E.; Freitas, M. A.; Harper, S. Q.
10.1101/2022.07.22.501148 — neuroscience — Posted on 2022-07-22
973 Obesity promotes Fumonisin B1 toxicity and induces hepatitis
Dopavogui, L.; Regnier, M.; Polizzi, A.; Ponchon, Q.; Smati, S.; Klement, W.; Lasserre, F.; Lukowicz, C.; Lippi, Y.; Fougerat, A.; Bertrand-Michel, J.; Naylies, C.; Canlet, C.; Debrauwer, L.; Gamet-Payrastre, L.; Dauriat, C.; Casas, J.; Croubels, S.; De Baere, S.; Burger, H. M.; Chassaing, B.; Ellero-Simatos, S.; Guillou, H.; Oswald, I. P.; LOISEAU, N.
10.1101/2022.07.22.500801 — pharmacology and toxicology — Posted on 2022-07-22
974 Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA
Keil, P.; Wulf, A.; Kachariya, N.; Reuscher, S.; Huehn, K.; Silbern, I.; Altmueller, J.; Stehle, R.; Zarnack, K.; Sattler, M.; Urlaub, H.; Straesser, K.
10.1101/2022.07.22.501171 — biochemistry — Posted on 2022-07-22
975 Integrative mapping of the dog epigenome: reference annotation for comparative inter-tissue and cross-species studies
Son, K. H.; Aldonza, M. B. D.; Nam, A.-R.; Lee, K.-H.; Lee, J.-W.; Shin, K.-J.; Kang, K.; Cho, J.-Y.
10.1101/2022.07.22.501075 — genomics — Posted on 2022-07-22
978 Transient RNA structures cause aberrant influenza virus replication and innate immune activation
French, H.; Pitre, E.; Oade, M. S.; Elshina, E.; Bisht, K.; King, A.; Bauer, D. L. V.; te Velthuis, A. J. W.
10.1101/2022.01.25.476955 — microbiology — Posted on 2022-07-22
979 An assessment of Nano-RECall: Interpretation of Oxford Nanopore sequence data for HIV-1 drug resistance testing
Delaney, K. E.; Ngobeni, T.; Woods, C. K.; Gordijn, C.; Claassen, M.; Parikh, U.; Harrigan, P. R.; Van Zyl, G. U.
10.1101/2022.07.22.501121 — microbiology — Posted on 2022-07-22
981 Synergism of interferon-beta with antiviral drugs against SARS-CoV-2 variants
Bojkova, D.; Stack, R.; Rothenburger, T.; Kandler, J. D.; Ciesek, S.; Wass, M. N.; Michaelis, M.; Cinatl, J.
10.1101/2022.07.22.501169 — microbiology — Posted on 2022-07-22
987 Canary in the cardiac-valve coal mine: Flow velocity and inferred shear during prosthetic valve closure --predictors of blood damage and clotting
Scotten, L. N.; Siegel, R.; Blundon, D. J.; Deutsch, M.-A.; Martin, T. R. P.; Dutton, J. W.; Kolahdouz, E. M.; Griffith, B. E.
10.1101/2022.06.23.497372 — bioengineering — Posted on 2022-07-22
988 Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
Kordon, S. P.; Dutka, P.; Adamska, J. M.; Bandekar, S. J.; Leon, K.; Adams, B.; Li, J.; Kossiakoff, A. A.; Arac, D.
10.1101/2022.07.20.500857 — biochemistry — Posted on 2022-07-22
991 The novel Rab5 effector FERRY links early endosomes with the translation machinery
Schuhmacher, J. S.; tom Dieck, S.; Christoforidis, S.; Landerer, C.; Davila Gallesio, J.; Hersemann, L.; Seifert, S.; Schaefer, R.; Giner, A.; Toth-Petroczy, A.; Kalaidzidis, Y.; Bohnsack, K. E.; Bohnsack, M. T.; Schuman, E. M.; Zerial, M.
10.1101/2021.06.20.449167 — cell biology — Posted on 2022-07-22
993 Release of VAMP5-positive extracellular vesicles by retinal Muller glia in vivo
Demais, V.; Pohl, A. M.; Wunderlich, K. A.; Pfaller, A. M.; Kaplan, L.; Barthelemy, A.; Dittrich, R.; Puig, B.; Giebel, B.; Hauck, S. M.; Pfrieger, F. W.; Grosche, A.
10.1101/2022.04.20.488918 — neuroscience — Posted on 2022-07-22
994 Diffusion MRI Head Motion Correction Methods are Highly Accurate but Impacted by Denoising and Sampling Scheme
Cieslak, M.; Cook, P. A.; Tapera, T. M.; Radhakrishnan, H.; Elliott, M. A.; Roalf, D. R.; Oathes, D. J.; Bassett, D. S.; Tisdall, M. D.; Rokem, A.; Grafton, S. T.; Satterthwaite, T. D.
10.1101/2022.07.21.500865 — neuroscience — Posted on 2022-07-22
996 Binary Interactome Models of Inner- Versus Outer-Complexome Organization
Lambourne, L.; Yadav, A.; Wang, Y.; Desbuleux, A.; Kim, D.-K.; Cafarelli, T.; Pons, C.; Kovacs, I. A.; Jailkhani, N.; Schlabach, S.; De Ridder, D.; Luck, K.; Bian, W.; Shen, Y.; Yang, Z.; Mee, M. W.; Helmy, M.; Jacob, Y.; Lemmens, I.; Rolland, T.; Cote, A. G.; Gebbia, M.; Kishore, N.; Knapp, J. J.; Mellor, J. C.; Reimand, J.; Tavernier, J.; Cusick, M. E.; Falter-Braun, P.; Spirohn, K.; Zhong, Q.; Aloy, P.; Hao, T.; Charloteaux, B.; Roth, F. P.; Hill, D. E.; Calderwood, M. A.; Twizere, J.-C.; Vidal, M.
10.1101/2021.03.16.435663 — systems biology — Posted on 2022-07-22
1004 Structural and functional asymmetry of the neonatal cerebral cortex
Williams, L. Z. J.; Fitzgibbon, S. P.; Bozek, J.; Winkler, A. M.; Dimitrova, R.; Poppe, T.; Schuh, A.; Makropoulos, A.; Cupitt, J.; O'Muircheartaigh, J.; Duff, E.; Cordero-Grande, L.; Price, A. N.; Hajnal, J. V.; Rueckert, D.; Smith, S. M.; Edwards, D.; Robinson, E. C.
10.1101/2021.10.13.464206 — neuroscience — Posted on 2022-07-22
1006 PDB ProtVista: A reusable and open-source sequence feature viewer
Deshpande, M.; Varadi, M.; Paysan-Lafosse, T.; Nair, S.; Piovesan, D.; Mir, S.; Gutmanas, A.; Tosatto, S. C. E.; Velankar, S.
10.1101/2022.07.22.500790 — bioinformatics — Posted on 2022-07-22
1007 Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during aging
Farra, Y. M.; Rivera, C.; Silvestro, M.; Matz, J.; Pratama, Y.; Kumari, P.; Vlahos, J.; Ramkhelawon, B.; Bellini, C.
10.1101/2022.07.21.501037 — bioengineering — Posted on 2022-07-22
1009 Independent evolution of influenza A virus H1N1 in pigs in Guatemala
Ortiz, L.; Geiger, G.; Ferreri, L.; Moran, D.; Alvarez, D.; Gonzalez-Reiche, A. S.; Mendez, D.; Rajao, D. S.; Cordon-Rosales, C.; Perez, D. R.
10.1101/2022.07.21.501070 — evolutionary biology — Posted on 2022-07-22
1010 linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells
Tornini, V. A.; Lee, H.-J.; Miao, L.; Tang, Y.; Dube, S. E.; Gerson, T.; Schmidt, V. J.; Du, K.; Kuchroo, M.; Kroll, F.; Vejnar, C. E.; Bazzini, A. A.; Krishnaswamy, S.; Rihel, J.; Giraldez, A.
10.1101/2022.07.21.501032 — developmental biology — Posted on 2022-07-22
1011 Suppression of systemic T cell immunity to viral infection during liver injury is prevented by inhibition of interferon and IL-10 signaling
Hackstein, P. C.; Spitzer, J.; Symeonidis, K.; Horvatic, H.; Bedke, T.; Steglich, B.; Assmus, L.; Odainic, A.; Kessler, N.; Klein, S.; Beyer, M.; Schmithausen, R.; Latz, E.; Kurts, C.; Trebicka, J.; Flavell, R.; Garbi, N.; Roers, A.; Huber, S.; Schmidt, S.; Knolle, P.; Abdullah, Z.
10.1101/2022.07.21.501031 — immunology — Posted on 2022-07-22
1013 Learning from pre-pandemic data to forecast viral antibody escape
Thadani, N. N.; Gurev, S.; Notin, P.; Youssef, N.; Rollins, N. J.; Sander, C.; Gal, Y.; Marks, D.
10.1101/2022.07.21.501023 — immunology — Posted on 2022-07-22
1015 Integrative analysis of the MD Anderson Prostate Cancer Patient-Derived Xenograft Series (MDA PCa PDX)
Anselmino, N.; Labanca, E.; Song, X.; Yang, J.; Shepherd, P. D.; Dong, J.; Kundra, R.; Schultz, N.; Zhang, J.; Araujo, J. C.; Aparicio, A. M.; Subudhi, S. K.; Corn, P. G.; Pisters, L. L.; Ward, J. F.; Davis, J. W.; Gueron, G.; Vazquez, E. S.; Logothetis, C. J.; Futreal, A.; Troncoso, P.; Chen, Y.; Navone, N. M.
10.1101/2022.07.21.500652 — cancer biology — Posted on 2022-07-22
1019 High-resolution de novo structure prediction from primary sequence
Wu, R.; Ding, F.; Wang, R.; Shen, R.; Zhang, X.; Luo, S.; Su, C.; Wu, Z.; Xie, Q.; Berger, B.; Ma, J.; Peng, J.
10.1101/2022.07.21.500999 — bioinformatics — Posted on 2022-07-22
1021 The chromosome-scale genome assembly of the yellowtail clownfish Amphiprion clarkii provides insights into melanic pigmentation of anemonefish
Moore, B.; Herrera, M.; Gairin, E.; Li, C.; Miura, S.; Jolly, J.; Mercader, M.; Izumiyama, M.; Kawai, E.; Ravasi, T.; Laudet, V.; Ryu, T.
10.1101/2022.07.21.500941 — genomics — Posted on 2022-07-22
1025 Durability of the Neutralizing Antibody Response to mRNA Booster Vaccination Against SARS-CoV-2 BA.2.12.1 and BA.4/5 Variants
QU, P.; Faraone, J. N.; Evans, J. P.; Zheng, Y.-M.; Carlin, C.; Lozanski, G.; Saif, L. J.; Oltz, E. M.; Gumina, R. J.; Liu, S.-L.
10.1101/2022.07.21.501010 — microbiology — Posted on 2022-07-22
1026 The novel compensatory reciprocal interplay between neutrophils and monocytes drives cancer progression
Chen, Z.; Soni, N.; Pinero, G.; Giotti, B.; Eddins, D. J.; Lindblad, K. E.; Ross, J. L.; Tsankova, N.; Gutmann, D. H.; Lira, S.; Lujambio, A.; Ghosn, E. E. B.; Tsankov, A. M.; Hambardzumyan, D.
10.1101/2022.07.21.500690 — immunology — Posted on 2022-07-22
1027 A linear DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain elicits protective immunity in domestic cats
Conforti, A.; Sanchez, E.; Salvatori, E.; Lione, L.; Compagnone, M.; Pinto, E.; Palombo, F.; Sun, Y.; Viscount, B.; Hayward, J.; Shorrock, C.; Diel, D. G.; Impellizeri, J. A.; Aurisicchio, L.
10.1101/2022.07.20.500860 — immunology — Posted on 2022-07-22
1029 A 3D bioengineered neural tissue model generated from patient-derived iPSCs develops Alzheimer's disease-related phenotypes
Lomoio, S.; PANDEY, R.; Rouleau, N.; Menicacci, B.; Kim, W.; Cantley, W.; Haydon, P.; Bennett, D.; Young-Pearse, T.; Carter, G.; Kaplan, D.; Tesco, G.
10.1101/2022.07.21.501004 — neuroscience — Posted on 2022-07-22
1030 Diffusion MRI Head Motion Correction Methods are Highly Accurate but Impacted by Denoising and Sampling Scheme
Cieslak, M.; Cook, P. A.; Tapera, T. M.; Radhakrishnan, H.; Elliott, M. A.; Roalf, D. R.; Oathes, D. J.; Bassett, D. S.; Tisdall, M. D.; Rokem, A.; Grafton, S. T.; Satterthwaite, T. D.
10.1101/2022.07.21.500865 — neuroscience — Posted on 2022-07-22
1031 Stimulus duration encoding occurs early in the moth olfactory pathway
Barta, T.; Montsempes, C.; Demondion, E.; Chatterjee, A.; Kostal, L.; Lucas, P.
10.1101/2022.07.21.501055 — neuroscience — Posted on 2022-07-22
1033 IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry
Lu, P.; Oetjen, K. A.; Bender, D. E.; Ruzinova, M. B.; Fisher, D. A.; Shim, K. G.; Pachynski, R. K.; Brennen, W. N.; Oh, S.; Link, D. C.; Thorek, D. L.
10.1101/2022.07.21.501021 — bioinformatics — Posted on 2022-07-22
1038 Temporal dynamics of metabolic acquisition in grafted engineered human liver tissue
Fortin, C. L.; McCray, T. N.; Saxton, S. H.; Johansson, F.; Andino, C. B.; Mene, J.; Wang, Y.; Stevens, K. R.
10.1101/2022.07.21.501040 — bioengineering — Posted on 2022-07-22
1039 Ferrous iron uptake via IRT1/ZIP evolved at least twice in green plants
Rodrigues, W. F. C.; Lisboa, A. B. P.; Lima, J. E.; Ricachenevsky, F. K.; Del-Bem, L.-E.
10.1101/2022.07.21.501042 — genomics — Posted on 2022-07-22
1041 Allelic diversity of the pharmacogene CYP2D6 in New Zealand Maori and Pacific peoples
Hitchman, L. M.; Faatoese, A.; Merriman, T. R.; Liau, Y.; Graham, O. E. E.; Kee, P. S.; Pearson, J. F.; Fakahau, T.; Cameron, V. A.; Kennedy, M. A.; Maggo, S. D. S.
10.1101/2022.07.21.501043 — genetics — Posted on 2022-07-22
1042 Population genomics of Xenopus laevis in southern Africa
Premachandra, T.; Cauret, C. M. S.; Conradie, W.; Measey, J.; Evans, B. J.
10.1101/2022.07.21.501003 — genetics — Posted on 2022-07-22
1043 Single-nucleus resolution mapping of the adult C. elegans and its application to elucidate inter- and trans-generational response to alcohol.
Truong, L.; CHEN, Y.-W.; Barrere-Cain, R.; Shuck, K.; Xiao, W.; Levenson, M. T.; da Veiga Beltrame, E.; Panter, B.; Reich, E.; Sternberg, P. W.; Yang, X.; Allard, P.
10.1101/2022.07.21.500524 — genetics — Posted on 2022-07-22
1045 Frequent pulse disturbances influence resistance and resilience in tropical marine microbial communities
Wijaya, W.; Suhaimi, Z.; Chua, C. X.; Sunil, R. S.; Kolundzija, S.; Rohaizat, A. M. B.; Azmi, N. B. M.; Hazrin-Chong, N. H.; Lauro, F. M.
10.1101/2022.07.21.501005 — ecology — Posted on 2022-07-22
1047 The APE2 nuclease is essential for DNA double strand break repairby microhomology-mediated end-joining.
Fleury, H.; MacEachern, M. K.; Stiefel, C. M.; Anand, R.; Sempeck, C.; Nebenfuehr, B.; Dodd, B.; Taylor, E.; Dansoko, D.; Ortega, R.; Leung, J. W.; Boulton, S. J.; Arnoult, N.
10.1101/2022.07.21.500989 — molecular biology — Posted on 2022-07-22
1048 TLR4 regulates proinflammatory intestinal immune responses mediated by an atopic gut microbiota
Campbell, E.; Maccio-Maretto, L.; Hesser, L. A.; Kemter, A. M.; Canani, R. B.; Nocerino, R.; Paparo, L.; Patry, R. T.; Nagler, C. R.
10.1101/2022.07.21.501027 — microbiology — Posted on 2022-07-22
1049 Highly pathogenic avian influenza H5N1 virus infections in wild red foxes (Vulpes vulpes) show neurotropism and adaptive virus mutations
Bordes, L.; Vreman, S.; Heutink, R.; Roose, M.; Venema, S.; Pritz-Verschuren, S. B. E.; Rijks, J.; Gonzales, J. L.; germeraad, e. a.; Engelsma, M. Y.; Beerens, N.
10.1101/2022.07.21.501071 — microbiology — Posted on 2022-07-22
1053 Human Brain Development: a cross-sectional and longitudinal study integrating multiple neuromorphological features
Kalantar Hormozi, H.; Patel, R.; Dai, A.; Ziolkowski, J.; Dong, H.; Holmes, A.; Raznahan, A.; Devenyi, G.; Chakravarty, M.
10.1101/2022.07.21.501018 — neuroscience — Posted on 2022-07-22
1054 Metabolic activity organizes olfactory representations
Qian, W. W.; Wei, J. N.; Sanchez-Lengeling, B.; Lee, B. K.; Luo, Y.; Vlot, M.; Dechering, K.; Peng, J.; Gerkin, R. C.; Wiltschko, A. B.
10.1101/2022.07.21.500995 — neuroscience — Posted on 2022-07-22
1055 A dolabralexin-deficient mutant provides insight into specialized diterpenoid metabolism in maize (Zea mays).
Murphy, K. M.; Dowd, T.; Khalil, A.; Char, S. N.; Yang, B.; Endelman, B. J.; Shih, P. M.; Topp, C. N.; Schmelz, E. A.; Zerbe, P.
10.1101/2022.07.21.500061 — plant biology — Posted on 2022-07-22
1057 Evaluating instruments for assessing healthspan: a multi-center cross-sectional study on health-related quality of life (HRQL) and frailty in the companion dog
Chen, F. L.; Ullal, T. V.; Graves, J. L.; Ratcliff, E. R.; Naka, A.; McKenzie, B.; Carttar, T. A.; Super, K. M.; Austriaco, J.; Weber, S. Y.; LaCroix-Fralish, M. L.; Vaughn, J.
10.1101/2022.07.21.500746 — physiology — Posted on 2022-07-22
1061 Extracellular Vesicles derived from Apis mellifera Royal Jelly promote wound healing by modulating inflammation and cellular responses
Alvarez, S.; Contreras-Kallens, P.; Aguayo, S.; Ramirez, O.; Vallejos, C.; Ruiz, J.; Carrasco-Gallardo, E.; Troncoso-Vera, S.; Morales, B.; Schuh, C. M. A. P.
10.1101/2022.07.21.501009 — bioengineering — Posted on 2022-07-22
1063 Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset
Mansur, A.; Joseph, R.; Beltran, P. M. J.; Udeshi, N.; Pearce, C.; Iwase, R.; McNamara, E.; Widrick, J.; Perez, C.; Ravenscroft, G.; Cole, P. A.; Carr, S. A.; Gupta, V. A.
10.1101/2022.07.21.501000 — genetics — Posted on 2022-07-22
1065 Global change drivers and the risk of infectious disease
Mahon, M. B.; Sack, A.; Aleuy, O. A.; Barbera, C.; Brown, E.; Buelow, H.; Civitello, D. J.; Cohen, J. M.; de Wit, L.; Forstchen, M.; Halliday, F. W.; Heffernan, P.; Knutie, S.; Korotasz, A.; Larson, J. G.; Rumschlag, S. L.; Selland, E.; Shepack, A.; Vincent, N.; Rohr, J. R.
10.1101/2022.07.21.501013 — ecology — Posted on 2022-07-22
1067 miR-221/222 drive synovial fibroblast expansion and pathogenesis of TNF-mediated arthritis
Roumelioti, F.; Tzaferis, C.; Konstantopoulos, D.; Papadopoulou, D.; Prados, A.; Sakkou, M.; Liakos, A.; Chouvardas, P.; Meletakos, T.; Pandis, Y.; Karagianni, N.; Denis, M.; Fousteri, M.; Armaka, M.; Kollias, G.
10.1101/2022.07.22.500939 — cell biology — Posted on 2022-07-22
1069 An unexpected histone chaperone function for the MIER1 histone deacetylase complex
Wang, S.; Fairall, L.; Pham, K.; Ragan, T. J.; Vashi, D.; Collins, M. O.; Dominguez, C.; Schwabe, J. W.
10.1101/2022.07.22.501112 — biochemistry — Posted on 2022-07-22
1070 Fluorogenic U-rich internal loop (FLURIL) tagging with bPNA enables intracellular RNA and DNA tracking
Liang, Y.; Willey, S.; Chung, Y.-C.; Lo, Y.-M.; Miao, S.; Rundell, S.; Tu, L.-C.; Bong, D.
10.1101/2022.07.21.501035 — cell biology — Posted on 2022-07-22
1073 Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant
Metcalfe, R. D.; Hanssen, E.; Fung, K. Y.; Aizel, K.; Kosasih, C. C.; Zlatic, C. O.; Doughty, L.; Morton, C. J.; Leis, A. P.; Parker, M. W.; Gooley, P. R.; Putoczki, T. L.; Griffin, M. D. W.
10.1101/2022.07.21.500383 — cell biology — Posted on 2022-07-22
1077 Pitfalls in methods to study colocalization of nanoparticles in mouse macrophage lysosomes
Moreno-Echeverri, A. M.; Susnik, E.; Vanhecke, D.; Taladriz-Blanco, P.; Balog, S.; Petri-Fink, A.; Rothen-Rutishauser, B.
10.1101/2022.07.21.500664 — cell biology — Posted on 2022-07-22
1082 A role for brassinosteroid signaling in decision-making processes in the Arabidopsis seedling
Kalbfuss, N.; Strohmayr, A.; Kegel, M.; Le, L.; Grosseholz, F.; Brunschweiger, B.; Stoeckl, K.; Wiese, C.; Franke, C.; Schiestl, C.; Prem, S.; Sha, S.; Franz-Oberdorf, K.; Hafermann, J.; Thieme, M. A.; Facher, E.; Palubicki, W.; Bolle, C.; Assaad, F. F.
10.1101/2022.07.15.499689 — plant biology — Posted on 2022-07-22
1085 Expansion microscopy of nuclear structure and dynamics in neutrophils
Holsapple, J. S.; Schnitzler, L.; Rusch, L.; Baldeweg, T. H.; Neubert, E.; Kruss, S.; Erpenbeck, L.
10.1101/2022.07.21.499684 — biophysics — Posted on 2022-07-22
1086 Single Photon smFRET. III. Application to Pulsed Illumination
Safar, M.; Saurabh, A.; Sarkar, B.; Fazel, M.; Ishii, K.; Tahara, T.; Sgouralis, I.; Presse, S.
10.1101/2022.07.20.500892 — biophysics — Posted on 2022-07-22
1087 Computational design of peptides to target Nav1.7 channel with high potency and selectivity for the treatment of pain
Nguyen, P. T.; Nguyen, H. M.; Wagner, K. M.; Stewart, R.; Singh, V.; Thapa, P.; Chen, Y.-J.; Lillya, M. W.; Ton, A. T.; Kondo, R.; Ghetti, A.; Pennington, M. W.; Hammock, B.; Griffith, T. N.; Sack, J. T.; Wulff, H.; Yarov-Yarovoy, V.
10.1101/2022.07.21.500925 — biophysics — Posted on 2022-07-22
1091 Clonal development, not aggregation, drives the transition to multicellularity in an isogenic model system
Pentz, J. T.; MacGillivray, K.; DuBose, J. G.; Conlin, P. L.; Reinhardt, E.; Libby, E.; Ratcliff, W. C.
10.1101/2022.07.21.500805 — evolutionary biology — Posted on 2022-07-22
1093 Hydrothermal Vent Species Assemblage Networks Identify Regional Connectivity Patterns in the Northwest Pacific
Brunner, O.; Chen, C.; Giguere, T.; Kawagucci, S.; Tunnicliffe, V.; Watanabe, H.; Mitarai, S.
10.1101/2022.07.20.500901 — ecology — Posted on 2022-07-22
1094 Symbiosis-driven development in an early branching metazoan
Ohdera, A. H.; Darymple, J.; Avila-Magana, V.; Sharp, V.; Watson, K.; McCauley, M.; Steinworth, B.; Diaz-Almeyda, E. M.; Kitchen, S. A.; Poole, A. Z.; Bellantuono, A. J.; Haridas, S.; Grigoriev, I. V.; Goentoro, L.; Vallen, E.; Baker, D. M.; LaJeunesse, T. C.; Loesgen, S.; martindale, m. q.; DeGennaro, M.; Fitt, W. K.; Medina, M.
10.1101/2022.07.21.500558 — developmental biology — Posted on 2022-07-22
1097 The Universal Endurance Microbiome?
Olbricht, H.; Twadell, K.; Stephens, C.; Sandel, B.; Whittall, J. B.
10.1101/2022.07.20.500882 — microbiology — Posted on 2022-07-22
1104 Arabidopsis latent virus 1, a comovirus widely spread in Arabidopsis thaliana collections
Verhoeven, A.; Kloth, K. J.; Kupczok, A.; Oymans, G. H.; Damen, J.; Rijnsburger, K.; Jiang, Z.; Deelen, C.; Sasidharan, R.; van Zanten, M.; van der Vlugt, R.
10.1101/2022.07.21.500942 — plant biology — Posted on 2022-07-22
1105 Mechanistic basis for targeting homologous recombination defective liver cancer via synthetic lethality
Zeng, M.; Tang, Z.; Ren, L.; Wang, H.; Wang, X.; Zhu, W.; Mao, X.; Li, Z.; Mo, X.; Chen, J.; Han, J.; Kong, D.; Ji, J.; Carr, A.; Liu, C.
10.1101/2022.07.21.500952 — cancer biology — Posted on 2022-07-22
1106 Sequence Dependent Internucleosomal Interactions Dominate Array Assembly
Wang, Y.; Stormberg, T. D.; Hashemi, M.; Kolomeisky, A.; Lyubchenko, Y. L.
10.1101/2022.07.20.500866 — biophysics — Posted on 2022-07-22
1108 Single Photon smFRET. I. Theory and Conceptual Basis
Saurabh, A.; Safar, M.; Sgouralis, I.; Fazel, M.; Presse, S.
10.1101/2022.07.20.500887 — biophysics — Posted on 2022-07-22
1111 Genetic variation in correlated regulatory region of Immunity
Avalos, D.; Rey, G.; Ribeiro, D. M.; Ramisch, A.; Dermitzakis, E. T.; Delaneau, O.
10.1101/2022.07.21.500922 — bioinformatics — Posted on 2022-07-22
1116 The fitness landscape of the mobilized colistin resistance gene mcr-1
Guo, Z.; Feng, S.; Liang, L.; Li, J.; Zhong, L.-L.; Zhao, H.; Tian, G.-b.; Yang, J.-R.
10.1101/2022.07.21.500813 — evolutionary biology — Posted on 2022-07-22
1118 Biopriming of broad bean seeds with entomopathogenic fungus Metarhizium robertsii does not affect invertebrate communities of the agroecosystem
Lubechanskii, I.; Novgorodova, T.; Panina, Y.; Kryukov, V.; Sorokina, V.; Sadokhina, T.; Bakshaev, D.; Dudko, R.; Gurina, A.; Glupov, V.
10.1101/2022.07.20.500881 — ecology — Posted on 2022-07-22
1120 Pre-Germinal Center Interactions with T Cells are Natural Checkpoints to Limit Autoimmune B Cell Responses
Parham, K. A.; Tan, X. X. S.; Morelli, D. M.; Chowdhury, L.; Craig, H. C.; Kerfoot, S. M.
10.1101/2022.07.20.500862 — immunology — Posted on 2022-07-22
1121 Characterization and Preclinical Treatment of Rotational Force-Induced Brain Injury
Umfress, A.; Chakraborti, A.; Devi, S. P. S.; Adams, R.; Epstein, D.; Massicano, A.; Sorace, A.; Singh, S.; Hossian, M. I.; Andrabi, S. A.; Crossman, D. K.; Kumar, N.; Mukhtar, M. S.; Simpson, C.; Abell, K.; Stokes, M.; Wiederhold, T.; Rosen, C.; Luo, H.; Lu, H.; Natarajan, A.; Bibb, J. A.
10.1101/2022.07.20.500670 — neuroscience — Posted on 2022-07-22
1124 GPC3-Unc5D complex structure and role in cell migration
Akkermans, O.; Delloye-Bourgeois, C.; Peregrina, C.; Carrasquero, M.; Kokolaki, M.; Berbeira Santana, M.; Chavent, M.; Reynaud, F.; Raj, R.; Agirre, J.; Aksu, M.; White, E.; Lowe, E.; ben Amar, D.; Zaballa, S.; Huo, J.; McCubbin, P. T.; Pakos, I.; Comoletti, D.; Owens, R.; Robinson, C. V.; castellani, V.; del Toro, D.; Seiradake, E.
10.1101/2022.07.21.500812 — neuroscience — Posted on 2022-07-22
1125 Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani, B.; Horien, C.; Ju, S.; Li, N.; Lacadie, C.; Shen, X.; Scheinost, D.; Constable, R. T.; Fredericks, C. A.
10.1101/2022.07.21.500964 — neuroscience — Posted on 2022-07-22
1127 Quantitative Census of Local Somatic Features in Mouse Visual Cortex
Elabbady, L.; Seshamani, S.; Mu, S.; Mahalingam, G.; Schneider-Mizell, C. M.; Bodor, A.; Bae, J. A.; Brittain, D.; Buchanan, J.; Bumbarger, D. J.; Castro, M. A.; Cobos, E.; Dorkenwald, S.; Fahey, P. G.; Froudarakis, E.; Halageri, A.; Jia, Z.; Jordan, C.; Kapner, D.; Kemnitz, N.; Kinn, S.; Lee, K.; Li, K.; Lu, R.; Macrina, T.; Mitchell, E.; Mondal, S. S.; Nehoran, B.; Papadopoulos, S.; Patel, S.; Pitkow, X.; Popovych, S.; Reimer, J.; Silversmith, W.; Sinz, F. H.; Takeno, M.; Torres, R.; Turner, N. L.; Wong, W.; Wu, J.; Yin, W.; Yu, S.-c.; Tolias, A.; Seung, H. S.; Reid, R. C.; Macarico da Costa
10.1101/2022.07.20.499976 — neuroscience — Posted on 2022-07-22
1137 Characterization of the human fetal rete region by single cell transcriptional analysis of gonads and mesonephros/epididymis
TAELMAN, J.; CZUKIEWSKA, S. M.; MOUSTAKAS, I.; CHANG, Y. W.; HILLENIUS, S.; van der HELM, T.; MEI, H.; FAN, X.; Chuva de Sousa Lopes, S. M.
10.1101/2022.07.20.500903 — developmental biology — Posted on 2022-07-22
1140 AGC Kinase Inhibitors Regulate STING Signaling Through SGK-Dependent and SGK-Independent Mechanisms
Cabrera, J. V. C.; Dang, H.; Zhang, Z.; Torres-Castillo, J. L.; Li, K.; Liu, P.; Aube, J.; Damania, B.; Hagan, R. S.; Baldwin, A. S.
10.1101/2022.07.21.500994 — immunology — Posted on 2022-07-22
1141 Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity.
Flores-Santibanez, F.; Rennen, S.; Fernandez, D.; De Nolf, C.; Gaete, S.; Fuentes, C.; Moreno, C.; Figueroa, D.; Lladser, A.; Iwawaki, T.; Bono, M. R.; Janssens, S.; Osorio, F.
10.1101/2022.07.20.500838 — immunology — Posted on 2022-07-22
1144 C-di-GMP signalling links biofilm formation and Mn(II) oxidation in Pseudomonas resinovorans.
Piazza, A.; Ciancio Casalini, L.; Sisti, F.; Fernandez, J.; Malone, J.; Ottado, J.; Serra, D. O.; Gottig, N.
10.1101/2022.07.20.500916 — microbiology — Posted on 2022-07-22
1146 Genomewide identification of subtelomeric silencing factors in budding yeast
Juarez-Reyes, A.; Avelar-Rivas, J. A.; Hernandez-Valdes, J. A.; Hua, B.; Campos, S. E.; Gonzalez, J.; Gonzalez, A.; Springer, M. S.; Mancera, E.; DeLuna, A.
10.1101/2022.07.20.500793 — genetics — Posted on 2022-07-22
1150 Transcriptome responses of virus-transmitting aphid vectors are shaped by the host plant and the virus mode of transmission
Chesnais, Q.; Golyaev, V.; Velt, A.; Rustenholz, C.; Verdier, M.; Brault, V.; Pooggin, M. M.; Drucker, M.
10.1101/2022.07.18.500449 — plant biology — Posted on 2022-07-22
1151 ADOPT: intrinsic protein disorder prediction through deep bidirectional transformers
Tamiola, K.; Fisicaro, C.; Dutton, O.; Hoffmann, F.; Henderson, L.; Owens, B. M. J.; Heberling, M.; Redl, I.; Paci, E.
10.1101/2022.05.25.493416 — bioinformatics — Posted on 2022-07-22
1152 Expression of neuronal Na+ leak channel, NALCN, provides for persistent invasion of metastasizing cancer cells
Iamshanova, O.; Gordienko, D.; Folcher, A.; Bokhobza, A.; Shapovalov, G.; Kannancheri-Puthooru, D.; Mariot, P.; Allart, L.; Desruelles, E.; Spriet, C.; Diez, R.; Oullier, T.; Marionneau-Lambot, S.; Brisson, L.; Geraci, S.; Impheng, H.; Lehenkyi, V.; Haustrate, A.; Mihalache, A.; Gosset, P.; Chadet, S.; Retif, S.; Sobilo, J.; Lerondel, S.; Laube, M.; Villari, G.; Serini, G.; Fiorio Pla, A.; Roger, S.; Fromont, G.; Djamgoz, M.; Clezardin, P.; Monteil, A.; Prevarskaya, N.
10.1101/2020.08.13.249169 — cell biology — Posted on 2022-07-22
1153 Assessment of AI-based Protein Structure Prediction for the NLRP3 Target
Yin, J.; Lei, J.; Yu, J.; Cui, W.; Satz, A. L.; Zhou, Y.; Feng, H.; Deng, J.; Su, W.; Kuai, L.
10.1101/2021.11.05.467381 — biochemistry — Posted on 2022-07-22
1154 A versatile, high-efficiency platform for CRISPR-based gene activation
Heidersbach, A. J.; Dorighi, K. M.; Gomez, J. A.; Jacobi, A. M.; Haley, B.
10.1101/2022.07.21.501015 — bioengineering — Posted on 2022-07-22
1155 Structural and functional analysis of the cerato-platanin-like effector protein Cpl1 suggests diverging functions in smut fungi
Weiland, P.; Dempwolff, F.; Steinchen, W.; Freibert, S.; Glatter, T.; Martin, R.; Bange, G.; Altegoer, F.
10.1101/2022.07.21.500954 — biochemistry — Posted on 2022-07-22
1157 DNA Methylation is stable after MMEJ and NHEJ double strand break repair
Bnaya, E.; Shilo, S.; Feldman, T.; Bacharach, T.; Moskovitz, Y.; Kadam, A.; Yedidim, P.; Azogy, H.; Kaushansky, N.; Chapal-Ilani, N.; Shlush, L. I.
10.1101/2022.07.21.500965 — genetics — Posted on 2022-07-22
1158 Integrating pharmacogenomics data-driven prediction with bulk and single-cell RNAseq to demonstrate the efficacy of an NAMPT inhibitor against aggressive, taxane-resistant, and stem-like cells in lethal prostate cancer
Mazumder, S.; Mitra Ghosh, T.; Mukherjee, U.; Chakravarti, S.; Amiri, F.; Hemmati, F.; Mistriotis, P.; Elhussin, I.; Salam, A. B.; Dean-Colomb, W.; Li, F.; Yates, C.; Arnold, R. D.; Mitra, A. K.
10.1101/2022.07.20.500378 — molecular biology — Posted on 2022-07-22
1160 PTPN22 R620W gene editing in T cells enhances low avidity TCR responses
Anderson, W.; Barahmand-pour-Whitman, F.; Linsley, P. S.; Cerosaletti, K.; Buckner, J. H.; Rawlings, D. J.
10.1101/2022.07.21.500924 — immunology — Posted on 2022-07-22
1161 AGC Kinase Inhibitors Regulate STING Signaling Through SGK-Dependent and SGK-Independent Mechanisms
Cabrera, J. V. C.; Dang, H.; Zhang, Z.; Torres-Castillo, J. L.; Li, K.; Liu, P.; Aube, J.; Damania, B.; Hagan, R. S.; Ernest, A. S.
10.1101/2022.07.21.500994 — immunology — Posted on 2022-07-22
1163 SNM1A (DCLRE1A) is required for the efficient repair of complex DNA breaks in human cells
Swift, L. P.; Lagerholm, B. C.; Baddock, H. T.; Ratnaweera, M.; Sengerova, B.; Lee, S. Y.; Ulrich, H. D.; Renz, C.; Waithe, D.; schofield, C. J.; McHugh, P. J.
10.1101/2022.07.21.500940 — biochemistry — Posted on 2022-07-21
1168 Engineering Toxoplasma transgenic tissue cysts.
Hong, D. D.; Brooks, K.; Goerner, A. L.; Vizcarra, E. A.; Loges, L. N.; Wilson, E. H.; White, M. W.
10.1101/2022.07.21.500998 — developmental biology — Posted on 2022-07-22
1170 Drosophila cap-binding protein eiF4EHP promotes translation via a 3'UTR-dependent mechanism under hypoxia and contributes to fruit fly adaptation to oxygen variations
Liang, M.; Hody, C.; Yammine, V.; Soin, R.; Sun, Y.; Lin, X.; Tian, X.; Meurs, R.; Perdrau, C.; Delacourt, N.; Andris, F.; Conrard, L.; Kruys, V.; Gueydan, C.
10.1101/2022.07.20.500870 — molecular biology — Posted on 2022-07-21
1172 A synthetic C2 auxotroph of Pseudomonas putida for evolutionary engineering of alternative sugar catabolic routes
Wirth, N. T.; Gurdo, N.; Krink, N.; Vidal Verdu, A.; Fernandez-Cabezon, L.; Wulff, T.; Nikel, P. I.
10.1101/2022.07.21.500976 — synthetic biology — Posted on 2022-07-21
1174 Cohesin is involved in transcriptional repression of stage-specific genes in the human malaria parasite
Rosa, C.; Singh, P.; Sinha, A.; Preiser, P. R.; Dedon, P. C.; Baumgarten, S.; Scherf, A.; Bryant, J. M.
10.1101/2022.07.21.500927 — molecular biology — Posted on 2022-07-21
1182 Establishment of Measles Virus Receptor-expressing Vero Cells Lacking Functional Poliovirus Receptors
Someya, K.; Okemoto-Nakamura, Y.; Kurata, T.; Kanbayashi, D.; Saito, N.; Itamochi, M.; Otsuki, N.; Hanada, K.; Takeda, M.
10.1101/2022.07.21.500891 — microbiology — Posted on 2022-07-21
1183 Constitutive production of flagellar proteins is required for proper flagellation in Shewanella putrefaciens
Schwan, M.; Khaledi, A.; Willger, S.; Papenfort, K.; Glatter, T.; Häussler, S.; Thormann, K. M.
10.1101/2022.07.21.500047 — microbiology — Posted on 2022-07-21
1184 Buying time: detecting VOCs in SARS-CoV-2 via co-evolutionary signals
Barrett, C.; Bura, A. C.; He, Q.; Huang, F. W.; Li, T. J. X.; Reidys, C. M.
10.1101/2022.07.21.500897 — bioinformatics — Posted on 2022-07-21
1187 Temporal profiling of CD4 T-cell activation and differentiation upon SARS-CoV-2 spike protein immunisation
Almeida-Santos, J.; Berkachy, R.; Tye, C. A.; Hassan, J.; Kalfaoglu, B.; Selkirk, M. E.; Ono, M.
10.1101/2022.07.21.500987 — immunology — Posted on 2022-07-21
1188 Hidden genetic variation in plasticity increases the potential to adapt to novel environments
Walter, G. M.; Clark, J.; Terranova, D.; Cozzolino, S.; Cristaudo, A.; Hiscock, S. J.; Bridle, J. R.
10.1101/2020.10.26.356451 — evolutionary biology — Posted on 2022-07-21
1189 An Open and Continuously Updated Fern Tree of Life
Nitta, J.; Schuettpelz, E.; Ramirez Barahona, S.; Iwasaki, W.
10.1101/2022.03.31.486640 — evolutionary biology — Posted on 2022-07-21
1192 Cholesterol binds the amphipathic helix of IFITM3 and regulates antiviral activity
Rahman, K.; Datta, S. A. K.; Beaven, A. H.; Jolley, A. A.; Sodt, A. J.; Compton, A. A.
10.1101/2022.04.21.488780 — immunology — Posted on 2022-07-21
1193 Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2-autoreceptor activity
Lycas, M. D.; Ejdrup, A. L.; Sorensen, A. T.; Haahr, N. O.; Jorgensen, S. H.; Guthrie, D. A.; Stoier, J. F.; Werner, C.; Newman, A. H.; Sauer, M.; Herborg, F. H.; Gether, U.
10.1101/2021.03.09.434538 — neuroscience — Posted on 2022-07-21
1195 FDA-approved carbonic anhydrase inhibitors reduce Amyloid beta pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness
Canepa, E.; Parodi-Rullan, R.; Vazquez-Torres, R.; Gamallo-Lana, B.; Guzman-Hernandez, R.; Lemon, N. L.; Angiulli, F.; Debure, L.; Ilies, M.; Ostergaard, L.; Wisniewski, T.; Gutierrez-Jimenez, E.; Mar, A.; Fossati, S.
10.1101/2022.07.19.500681 — neuroscience — Posted on 2022-07-21
1198 Haplotype-aware pantranscriptome analyses using spliced pangenome graphs
Sibbesen, J. A.; Eizenga, J. M.; Novak, A. M.; Siren, J.; Chang, X.; Garrison, E.; Paten, B.
10.1101/2021.03.26.437240 — bioinformatics — Posted on 2022-07-21
1199 Structural variation turnovers and defective genomes: key drivers for the in vitro evolution of the large double-stranded DNA koi herpesvirus (KHV)
Fuandila, N. N.; Gosselin-Grenet, A.-S.; Tilak, M.-K.; Bergmann, S. M.; Escoubas, J.-M.; Klafack, S.; Lusiastuti, A. M.; Yuhana, M.; Fiston-Lavier, A.-S.; Avarre, J.-C.; Cherif, E.
10.1101/2022.03.10.483410 — genomics — Posted on 2022-07-21
1200 A domesticated fungal cultivar recycles its cytoplasmic contents as nutritional rewards for its leafcutter ant farmers
Leal-Dutra, C. A.; Yuen, L. M.; Marques, P. E.; Guedes, B. A. M.; Contreras-Serrano, M.; Shik, J. Z.
10.1101/2022.03.03.482823 — microbiology — Posted on 2022-07-21
1203 Plasmodium-encoded murine IL-6 impairs liver stage infection and elicits long-lasting sterilizing immunity
Belhimeur, S.; Briquet, S.; Peronet, R.; Pham, J.; Commere, P.-H.; Formaglio, P.; Amino, R.; Scherf, A.; Silvie, O.; MECHERI, S.
10.1101/2021.11.16.468835 — immunology — Posted on 2022-07-21
1211 A de novo transcriptome assembly of the annelid worm Hediste diversicolor
Samico, R.; Machado, A.; Domingues, M.; Hagemann, A.; Valente, L.; Malzahn, A.; Gomes-dos-Santos, A.; Ruivo, R.; Monroig, O.; Castro, F.
10.1101/2022.07.20.500767 — genomics — Posted on 2022-07-21
1212 Characterization of the immunoglobulin lambda chain locus from diverse populations reveals extensive genetic variation
Gibson, W. S.; Rodriguez, O. L.; Shields, K.; Silver, C. A.; Dorgham, A.; Emery, M.; Deikus, G.; Sebra, R. S.; Eichler, E.; Bashir, A.; Smith, M.; Watson, C. T.
10.1101/2022.07.20.500849 — genetics — Posted on 2022-07-21
1217 Coupling of oxytocin and cholecystokinin pathways in the hypothalamus is required for gut-to-brain homeostatic feeding control
Gruber, T.; Lechner, F.; Murat, C.; Contreras, R. E.; Sanchez-Quant, E.; Miok, V.; Le Thuc, O.; Gonzales-Garcia, I.; Williams, R. H.; Pfluger, P. T.; Mueller, T. D.; Woods, S. C.; Martinez-Jimenez, C. P.; Tschoep, M. H.; Grinevich, V.; Garcia-Caceres, C.
10.1101/2022.07.20.500778 — neuroscience — Posted on 2022-07-21
1222 Predictors of genomic diversity within North American squamates
Larkin, I. E.; Myers, E. A.; Carstens, B. C.; Barrow, L. N.
10.1101/2022.07.20.500845 — genomics — Posted on 2022-07-21
1227 Three-dimensional structured illumination microscopy with enhanced axial resolution
Li, X.; Wu, Y.; Su, Y.; Suarez, I. A. R.; Matthaeus, C.; Updegrove, T. B.; Wei, Z.; Zhang, L.; Sasaki, H.; Li, Y.; Guo, M.; Giannini, J. P.; Vishwasrao, H. D.; Chen, J.; Lee, S.-J. J.; Shao, L.; Liu, H.; Ramamurthi, K. S.; Taraska, J. W.; Upadhyaya, A.; La Riviere, P.; Shroff, H.
10.1101/2022.07.20.500834 — cell biology — Posted on 2022-07-21
1232 Superficial white matter across the lifespan: volume, thickness, change, and relationship with cortical features
Schilling, K.; Archer, D. B.; Rheault, F.; Lyu, I.; Huo, Y.; Cai, L. Y.; Bunge, S.; Weiner, K. S.; Gore, J. C.; Anderson, A. W.; Landman, B. A.
10.1101/2022.07.20.500818 — neuroscience — Posted on 2022-07-21
1233 Enriching Representation Learning Using 53 Million Patient Notes through Human Phenotype Ontology Embedding
Daniali, M.; Galer, P. D.; Lewis-Smith, D.; Parthasarathy, S.; Kim, E.; Salvucci, D. D.; Miller, J. M.; Haag, S.; Helbig, I.
10.1101/2022.07.20.500809 — bioinformatics — Posted on 2022-07-21
1234 Accelerating genomic workflows using NVIDIA Parabricks
O'Connell, K. A.; Yosufzai, Z. B.; Campbell, R. A.; Lobb, C. J.; Engelken, H. T.; Gorrell, L. M.; Carlson, T. B.; Catana, J. J.; Mikdadi, D.; Bonazzi, V. R.; Klenk, J. A.
10.1101/2022.07.20.498972 — bioinformatics — Posted on 2022-07-21
1235 Generation of cardiomyocytes from human induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists
Ahmad, F. S.; Jin, Y.; Grassam-Rowe, A. D.; Zhou, Y.; Yuan, M.; Fan, X.; Zhou, R.; Mu-u-min, R.; O'Shea, C.; Ibrahim, A. M.; Hyder, W.; Aguib, Y.; Yacoub, M.; Pavlovic, D.; Zhang, Y.; Tan, X.; Terrar, D. A.; Lei, M.
10.1101/2022.07.20.499551 — bioengineering — Posted on 2022-07-21
1236 ABC-transporter CFTR folds with high fidelity through a modular, stepwise pathway
Im, J.; Hillenaar, T.; Yeoh, H. Y.; Sahasrabudhe, P.; Mijnders, M.; van Willigen, M.; van der Sluijs, P.; Braakman, I.
10.1101/2022.07.20.500765 — biochemistry — Posted on 2022-07-21
1238 Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference
Meng, X.; Navoly, G.; Giannakopoulou, O.; DL, D.; Koller, D.; Pathak, G.; Koen, N.; Lin, K.; Renteria, M.; Feng, Y.; Gaziano, J. M.; Stein, D.; Zar, H.; Campbell, M.; van Heel, D.; Trivedi, B.; Finer, S.; McQuillin, A.; Bass, N.; Chundru, V. K.; Martin, H.; Huang, Q. Q.; Valkovskaya, M.; Kuo, P.-H.; Chen, H.-C.; Tsai, S.-J.; Liu, Y.-L.; Kendler, K.; Peterson, R.; Cai, N.; Fang, Y.; Sen, S.; Scott, L.; Burmeister, M.; Loos, R.; Preuss, M.; Actkins, K.; Davis, L.; Uddin, M.; Wani, A.; Wildman, D.; Ursano, R.; Kessler, R.; Kanai, M.; Okada, Y.; Sakaue, S.; Rabinowitz, J.; Maher, B.; Uhl, G.; Eato
10.1101/2022.07.20.500802 — genetics — Posted on 2022-07-21
1239 Freshwater connectivity transforms spatially integrated signals of biodiversity
Littlefair, J. E.; Hleap, J. S.; Palace, V.; Rennie, M. D.; Paterson, M. J.; Cristescu, M. E.
10.1101/2022.07.20.500822 — ecology — Posted on 2022-07-21
1241 A Non-invasive, Biomarker Assay for Detecting Chronic Wasting Disease Pathology in White-tailed Deer
Bradley, R. D.; Roberts, E. K.; Worsham, A. E.; Ashton, M. N.; Wright, E. A.; Saleh, N.; Hardy, D. M.
10.1101/2022.07.20.500695 — molecular biology — Posted on 2022-07-21
1243 Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue
Murthy, M.; Shireby, G.; Miki, Y.; Vire, E.; Lashley, T.; Warner, T. T.; Mill, J.; Bettencourt, C.
10.1101/2022.07.20.500795 — neuroscience — Posted on 2022-07-21
1245 NeuronBridge: an intuitive web application for neuronal morphology search across large data sets
Clements, J.; Goina, C.; Hubbard, P. M.; Kawase, T.; Olbris, D. J.; Otsuna, H.; Svirskas, R.; Rokicki, K.
10.1101/2022.07.20.500311 — neuroscience — Posted on 2022-07-21
1246 Elucidating the patterns of pleiotropy and its biological relevance in maize
Khaipho-Burch, M. B.; Ferebee, T.; Giri, A.; Ramstein, G. P.; Monier, B.; Yi, E.; Romay, C.; Buckler, E. S.
10.1101/2022.07.20.500810 — plant biology — Posted on 2022-07-21
1253 Establishment of Transgenic Fluorescent Mice for Screening Synaptogenic Adhesion Molecules
Yang, L.; Zhang, J.; Zhang, Y.; Wang, L.; Wang, X.; Wang, S.; Li, K.; Wei, M.; Zhang, C.
10.1101/2022.07.20.500799 — neuroscience — Posted on 2022-07-21
1254 Apicosome: newly identified cell-type-specific organelle in mouse cochlear and vestibular hair cells
Li, X.; Zhao, Q.; Yu, X.; Cao, W.; Zhang, Y.; Feng, W.; Jiang, L.; He, D. Z.; Qi, R. Z.; Huang, P.
10.1101/2022.07.20.500729 — neuroscience — Posted on 2022-07-21
1255 Age-dependent NMDA receptor function is regulated by the Amyloid Precursor Protein
Rajao-Saraiva, J.; Temido-Ferreira, M.; Coelho, J. E.; Ribera, A.; Moreno, S.; Willem, M.; Marie, H.; Lopes, L. V.; Pousinha, P. A.
10.1101/2022.07.20.500736 — neuroscience — Posted on 2022-07-21
1262 Extracellular vesicle microRNAs contribute to Notch signaling pathway in T-Cell Acute Lymphoblastic Leukemia
Colangelo, T.; Panelli, P.; Mazzarelli, F.; Tamiro, F.; Melocchi, V.; Palumbo, O.; Rossi, G.; Giambra, V.; Bianchi, F.
10.1101/2022.07.20.500780 — cancer biology — Posted on 2022-07-21
1263 Accurate background reduction in adaptive optical 3D-STED nanoscopy by dynamic phase switching
Tu, S.; Liu, X.; Yuan, D.; Tao, W.; Han, Y.; Shi, Y.; Li, Y.; Kuang, C.; Liu, X.; Yao, Y.; Xu, Y.; Hao, X.
10.1101/2022.06.25.497623 — biophysics — Posted on 2022-07-21
1266 Decoding rRNA Sequences for Improved Metagenomics in Sylvatic Mosquito Species
Koh, C.; Frangeul, L.; Blanc, H.; Ngoagouni, C.; Boyer, S.; Dussart, P.; Grau, N.; Girod, R.; Duchemin, J.-B.; Saleh, M.-C.
10.1101/2022.02.01.478639 — bioinformatics — Posted on 2022-07-21
1267 HAT: Haplotype Assembly Tool using short and error-prone long reads
Shirali Hossein Zade, R.; Urhan, A.; Assis de Souza, A.; Singh, A.; Abeel, T.
10.1101/2022.07.20.500775 — bioinformatics — Posted on 2022-07-21
1269 Structure of the human FERRY Rab5 effector complex
Quentin, D.; Schuhmacher, J.; Klink, B. U.; Lauer, J.; Shaikh, T.; Huis in 't Veld, P. J.; Welp, L. M.; Urlaub, H.; Zerial, M.; Raunser, S.
10.1101/2021.06.21.449265 — biochemistry — Posted on 2022-07-21
1270 DNA-binding mechanism and evolution of Replication Protein A
Madru, C.; Martinez-Carranza, M.; Laurent, S.; Alberti, A. C.; Chevreuil, M.; Raynal, B.; Haouz, A.; Le Meur, R. A.; Delarue, M.; Flament, D.; Krupovic, M.; Legrand, P.; Sauguet, L.
10.1101/2022.07.20.500673 — biochemistry — Posted on 2022-07-21
1271 On the Genes, Genealogies, and Geographies of Quebec
Anderson-Trocme, L.; Nelson, D.; Zabad, S.; Diaz-Papkovich, A.; Baya, N.; Touvier, M.; Jeffery, B.; Dina, C.; Vezina, H.; Kelleher, J.; Gravel, S.
10.1101/2022.07.20.500680 — genomics — Posted on 2022-07-21
1272 Extended family with germline pathogenic variant in polymerase delta provides strong evidence for recessive effect of proofreading inactivation
Andrianova, M. A.; Seplyarskiy, V. B.; Terradas, M.; Sanchez-Heras, A. B.; Mur, P.; Soto, J. L.; Aiza, G.; Kondrashov, F. A.; Kondrashov, A. S.; Bazykin, G. A.; Valle, L.
10.1101/2022.07.20.500591 — genetics — Posted on 2022-07-21
1275 Identification of Antigenic Regions Responsible for inducing Type 1 diabetes mellitus
Kumar, N.; Patiyal, S.; Choudhury, S.; Tomer, R.; Dhall, A.; Raghava, G. P. S.
10.1101/2022.07.20.500753 — bioinformatics — Posted on 2022-07-21
1276 Homologue Series Detection and Management in LC-MS data with homologueDiscoverer
Mildau, K.; van der Hooft, J. J. J.; Flasch, M.; Warth, B.; El Abiead, Y.; Koellensperger, G.; Zanghellini, J.; Bueschl, C.
10.1101/2022.07.20.500749 — bioinformatics — Posted on 2022-07-21
1278 De novo discovery of traits co-occurring with chronic obstructive pulmonary disease
Golovina, E.; Fadason, T.; Jaros, R. K.; Kumar, H.; John, J.; Burrowes, K.; Tawhai, M.; O'Sullivan, J. M.
10.1101/2022.07.20.500731 — genomics — Posted on 2022-07-21
1281 Stepwise recombination suppression around the mating-type locus in the fungus Schizothecium tetrasporum (Ascomycota, Sordariales)
Vittorelli, N.; Snirc, A.; Levert, E.; Gautier, V.; Lalanne, C.; De Filippo, E.; Rodriguez de la Vega, R. C.; Gladieux, P.; Guillou, S.; Zhang, Y.; Tejomurthula, S.; Grigoriev, I.; Debuchy, R.; Silar, P.; Giraud, T.; Hartmann, F.
10.1101/2022.07.20.500756 — evolutionary biology — Posted on 2022-07-21
1282 Climate change in the Arctic: testing the poleward expansion of ticks and tick-borne diseases
McCoy, K.; Toty, C.; Dupraz, M.; Tornos, J.; Gamble, A.; Garnier, R.; Descamps, S.; Boulinier, T.
10.1101/2022.07.20.500759 — ecology — Posted on 2022-07-21
1284 What drives prey selection? Assessment of tiger food habits across the Terai-Arc landscape, India
Biswas, S.; Kumar, S.; Bandyopadhyay, M.; Patel, S. K.; Lyngdoh, S.; Pandav, B.; Mondol, S.
10.1101/2022.07.20.500750 — ecology — Posted on 2022-07-21
1285 Ageing disrupts MANF-mediated immune modulation during skeletal muscle regeneration
Sousa, N. S.; Bras, M. F.; Antunes, I. B.; Lindholm, P.; Neves, J.; Sousa-Victor, P.
10.1101/2022.07.20.500588 — cell biology — Posted on 2022-07-21
1287 Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress
Sandoz, J.; Cigrang, M.; Catez, P.; Donnio, L.-m.; Elly, C.; Berico, p.; Braun, C.; Alekseev, S.; Egly, J.-m.; Giglia-Mari, G.; Compe, E.; Coin, F.
10.1101/2022.07.20.499545 — molecular biology — Posted on 2022-07-21
1290 Cannabinoids Activate the Insulin Pathway to Modulate Mobilization of Cholesterol in C. elegans
Hernandez-Cravero, B.; Gallino, S.; Florman, J.; Vranich, C.; Philippe, D.; Elgoyhen, A. B.; Alkema, M.; Diego De Mendoza, D.
10.1101/2022.07.20.500754 — neuroscience — Posted on 2022-07-21
1294 Near-chromosomal de novo assembly of Bengal tiger genome reveals genetic hallmarks of apex-predation
Shukla, H.; Suryamohan, K.; Khan, A.; Mohan, K.; Perumal, R.; Mathew, O.; Menon, R.; Dixon, M. D.; Muraleedharan, M.; Kuriakose, B.; Michael, S.; Krishnakutty, S.; Zachariah, A.; Seshagiri, S.; Ramakrishnan, U.
10.1101/2022.05.14.491975 — genomics — Posted on 2022-07-21
1296 Synthetic lethal screening identifies existing autophagy drugs with selective viability effects on Neurofibromatosis type-1 model systems
Wang, Y.; Stevens, M.; Mandigo, T. R.; Bouley, S. J.; Sharma, A.; Sengupta, S.; Housden, A. E.; Perrimon, N.; Walker, J. A.; Housden, B. E.
10.1101/2021.12.20.473481 — cancer biology — Posted on 2022-07-21
1297 Densified Collagen Tubular Grafts for Human Tissue Replacement and Disease Modelling Applications
Justin, A. W.; Cammarata, F.; Guy, A. A.; Estevez, S. R.; Burgess, S.; Davaapil, H.; Stavropoulou-Tatla, A.; Ong, J.; Jacob, A. G.; Saeb-Parsy, K.; Sinha, S.; Markaki, A. E.
10.1101/2021.02.05.429744 — bioengineering — Posted on 2022-07-21
1298 Newfoundland and Labrador: A mosaic founder population of an Irish and British diaspora from 300 years ago.
Gilbert, E. H.; Zurel, H.; MacMillan, M. E.; Demirez, S.; Mirhendi, S.; Merrigan, M.; O'Reilly, S.; Molloy, A. M.; Brody, L. C.; Bodmer, W. F.; Leach, R. A.; Scott, R. E. M.; Mugford, G.; Randhawa, R.; Stephens, J. C.; Symington, A. L.; Cavalleri, G. L.; Phillips, M. S.
10.1101/2022.04.01.486593 — genetics — Posted on 2022-07-21
1302 Biological complexity facilitates tuning of the neuronal parameter space
Schneider, M.; Bird, A. D.; Gidon, A.; Triesch, J.; Jedlicka, P.; Cuntz, H.
10.1101/2021.05.04.442120 — neuroscience — Posted on 2022-07-21
1304 Testis-specific H2BFWT disrupts nucleosome integrity through reductions of DNA-histone interactions
Ding, D.; Pang, M. Y. H.; Deng, M.; Nguyen, T. T.; Sun, X.; Xu, Z.; Zhang, Y.; Zhai, Y.; Yan, Y.; Ishibashi, T.
10.1101/2022.07.20.500751 — biochemistry — Posted on 2022-07-21
1306 Genome-wide SNPs reveal the social structure and invasion pathways of the invasive tropical fire ant (Solenopsis geminata)
LENANCKER, P.; Walsh, T.; Metcalfe, S.; Gotzek, D.; Hoffmann, B. D.; Lach, L.; Tay, W. T.; ELFEKIH, S.
10.1101/2022.07.20.500883 — genetics — Posted on 2022-07-21
1307 Blue turns to grey - Paleogenomic insights into the evolutionary history and extinction of the blue antelope (Hippotragus leucophaeus)
Hempel, E.; Bibi, F.; Faith, J. T.; Koepfli, K.-P.; Klittich, A. M.; Duchene, D. A.; Brink, J. S.; Kalthoff, D. C.; Dalen, L.; Hofreiter, M.; Westbury, M. V.
10.1101/2022.04.12.487785 — evolutionary biology — Posted on 2022-07-21
1309 Gabapentin Disrupts Binding of Perlecan to the α2δ1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation
Fernandez, P. C. R.; Wright, C. S.; Masterson, A. N.; Yi, X.; Tellman, T. V.; Bonteanu, A.; Rust, K.; Noonan, M. L.; White, K. E.; Lewis, K. J.; Sankar, U.; Hum, J. M.; Bix, G.; Wu, D.; Robling, A. G.; Sardar, R.; Farach-Carson, M. C.; Thompson, W. R.
10.1101/2022.07.20.500827 — molecular biology — Posted on 2022-07-21
1311 Two canonically aerobic foraminifera express distinct peroxisomal and mitochondrial metabolisms
Powers, C.; Gomaa, F.; Billings, E. B.; Utter, D.; Beaudoin, D.; Edgcomb, V. P.; Hansel, C. M.; Wankel, S.; Filipsson, H. L.; Zhang, Y.; Bernhard, J. M.
10.1101/2022.07.20.500910 — microbiology — Posted on 2022-07-21
1313 Language models of protein sequences at the scale of evolution enable accurate structure prediction
Lin, Z.; Akin, H.; Rao, R.; Hie, B.; Zhu, Z.; Lu, W.; dos Santos Costa, A.; Fazel-Zarandi, M.; Sercu, T.; Candido, S.; Rives, A.
10.1101/2022.07.20.500902 — synthetic biology — Posted on 2022-07-21
1315 The structure of arginyltransferase 1 (ATE1)
Van, V.; Ejimogu, N.-E.; Bui, T. S.; Smith, A. T.
10.1101/2022.07.20.500667 — biochemistry — Posted on 2022-07-21
1316 DNA-binding mechanism and evolution of Replication Protein A
Madru, C.; Martinez-Carranza, M.; Laurent, S.; Alberti, A. C.; Chevreuil, M.; Raynal, B.; Haouz, A.; Le Meur, R. A.; Delarue, M.; Flament, D.; Kuprovic, M.; Legrand, P.; Sauguet, L.
10.1101/2022.07.20.500673 — biochemistry — Posted on 2022-07-21
1317 Requirement of sequential hydrolysis by CD73 and ALP for uptake of vitamin B2 into cells
Shichinohe, N.; Kobayashi, D.; Izumi, A.; Hatanaka, K.; Fujita, R.; Kinoshita, T.; Inoue, N.; Hamaue, N.; Wada, K.; Murakami, Y.
10.1101/2022.07.20.500786 — biochemistry — Posted on 2022-07-21
1318 Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder
Kordon, S. P.; Dutka, P.; Adamska, J. M.; Bandekar, S. J.; Leon, K.; Adams, B.; Li, J.; Kossiakoff, A. A.; Arac, D.
10.1101/2022.07.20.500857 — biochemistry — Posted on 2022-07-21
1319 Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.
Soni, K.; Sivadas, A.; Horvath, A.; Dobrev, N.; Hayashi, R.; Kiss, L.; Simon, B.; Wild, K.; Dr. Sinning, I.; Fischer, T.
10.1101/2022.07.20.500385 — molecular biology — Posted on 2022-07-21
1323 Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut
Hsiao, T.-H.; Chou, C.-H.; Chen, Y.-L.; Wang, P.-H.; Mong, G.-J. B.; Lee, T.-H.; Wu, T.-Y.; Li, P.-T.; Li, C.-W.; Lai, Y.-L.; Tseng, Y.-L.; Shih, C.-J.; Chen, M.-J.; Chiang, Y.-R.
10.1101/2022.07.20.500890 — microbiology — Posted on 2022-07-20
1324 Acanthamoeba polyphaga de novo transcriptome and its dynamics during Mimivirus infection
Nuri, R.; Feldmesser, E.; Fridmann-Sirkis, Y.; Keren-Shaul, H.; Nevo, R.; Minsky, A.; Reich, Z.
10.1101/2022.07.20.500700 — microbiology — Posted on 2022-07-20
1326 DNA methyltransferase enhanced Fusobacterium nucleatum genetics
Umana, A.; Nguyen, T. T. D.; Sanders, B. E.; Williams, K.; Wozniak, B.; Slade, D. J.
10.1101/2022.07.20.500824 — microbiology — Posted on 2022-07-20
1327 Combined oral vaccination with niche competition can generate sterilizing immunity against entero-pathogenic bacteria
Lentsch, V.; Woller, A.; Moresi, C.; Fattinger, S. A.; Aslani, S.; Hardt, W.-D.; Loverdo, C.; Diard, M.; Slack, E.
10.1101/2022.07.20.498444 — microbiology — Posted on 2022-07-20
1328 Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds
Dumeaux, V.; Massahi, S.; Bettauer, V.; Khurdia, S. S.; Costa, A. C. B. P.; Omran, R. P.; Simpson, S.; Xie, J. L.; Whiteway, M.; Berman, J.; Hallett, M. T.
10.1101/2022.07.20.500774 — microbiology — Posted on 2022-07-21
1330 Integrated multi-cohort analysis of the Parkinson's disease gut metagenome
Boktor, J. C.; Sharon, G.; Verhagen Metman, L. A.; Hall, D. A.; Engen, P. A.; Zreloff, Z.; Hakim, D. J.; Bostick, J. W.; Ousey, J.; Lange, D.; Humphrey, G.; Ackermann, G.; Carlin, M.; Knight, R.; Keshavarzian, A.; Mazmanian, S. K.
10.1101/2022.07.20.500694 — microbiology — Posted on 2022-07-21
1331 Molecular characterization of extended-spectrum beta-lactamase-producing extra-intestinal pathogenic Escherichia coli isolated in a university teaching hospital Dakar-Senegal
DOSSOUVI, K. M.; Sambe Ba, B.; Lo, G.; Cisse, A.; Ba-Diallo, A.; Ndiaye, I.; Dieng, A.; Ndiaye, S. M. L.; Fall, C.; Tine, A.; Karam, F.; Diagne-Samb, H.; Ngom-Cisse, S.; Diop-Ndiaye, H.; Toure-Kane, C.; Gaye-Diallo, A.; Mboup, S.; Boye, C. S. B.; Dieye, Y.; Seck, A.; Camara, M.
10.1101/2022.07.20.500880 — microbiology — Posted on 2022-07-21
1332 Cell envelope remodeling requires high concentrations of biotin during Mycobacterium abscessus model lung infection
Sullivan, M. R.; McGowen, K.; Liu, Q.; Akusobi, C.; Young, D. C.; Mayfield, J. A.; Raman, S.; Wolf, I. D.; Moody, D. B.; Aldrich, C. C.; Muir, A.; Rubin, E. J.
10.1101/2022.07.20.500843 — microbiology — Posted on 2022-07-21
1333 Hyperinsulinemia acts through acinar cell insulin receptors to drive obesity-associated pancreatic cancer initiation by promoting digestive enzyme production and inflammation
Zhang, A. M. Y.; Xia, Y. H.; Lin, J. S. H.; Chu, K. H.; Ruiter, T. J. J.; Yang, J. C. C.; Chen, N.; Chhuor, J.; Patil, S.; Cen, H. H.; Rideout, E.; Richard, V. R.; Schaeffer, D. F.; Zahedi, R. P.; Borchers, C. H.; Johnson, J. D.; Kopp, J.
10.1101/2022.05.06.490845 — cancer biology — Posted on 2022-07-20
1334 Safety and biodistribution of NanoligomersTM targeting SARS-CoV-2 genome for treatment of COVID-19
McCollum, C. R.; Courtney, C. M.; O'Connor, N. J.; Aunins, T. R.; Jordan, T. X.; Rogers, K.; Brindley, S.; Brown, J. M.; Nagpal, P.; Chatterjee, A.
10.1101/2022.07.19.500688 — bioengineering — Posted on 2022-07-20
1335 Evasion of neutralizing antibodies by Omicron sublineage BA.2.75
Sheward, D. J.; Kim, C.; Fischbach, J.; Muschiol, S.; Ehling, R. A.; Björkström, N. K.; Karlsson Hedestam, G. B.; Reddy, S. T.; Albert, J.; Peacock, T. P.; Murrell, B.
10.1101/2022.07.19.500716 — immunology — Posted on 2022-07-20
1337 Similarity in evoked responses does not imply similarity in macroscopic network states across tasks
Rasero, J.; Betzel, R.; Sentis, A. I.; Kraynak, T. E.; Gianaros, P. J.; Verstynen, T.
10.1101/2021.11.27.470015 — neuroscience — Posted on 2022-07-20
1338 "Self-inactivating" rabies viruses are susceptible to loss of their intended attenuating modification
Jin, L.; Matsuyama, M.; Sullivan, H. A.; Zhu, M.; Lavin, T. K.; Hou, Y.; Lea, N. E.; Pruner, M. T.; Dam Ferdinez, M. L.; Wickersham, I. R.
10.1101/550640 — neuroscience — Posted on 2022-07-20
1339 NPOmix: a machine learning classifier to connect mass spectrometry fragmentation data to biosynthetic gene clusters
Leao, T. F.; Wang, M.; da Silva, R.; Gurevich, A.; Bauermeister, A.; P. Gomes, P. W.; Brejnrod, A. D.; Glukhov, E.; Aron, A.; J. R. Louwen, J.; Woo Kim, H.; Reher, R.; F. Fiore, M.; van der Hooft, J. J. J.; Gerwick, L.; Gerwick, W. H.; Bandeira, N.; Dorrestein, P. C.
10.1101/2021.10.05.463235 — bioinformatics — Posted on 2022-07-20
1341 Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes
Kitamoto, T.; Lee, Y.-K.; Sultana, N.; McKimpson, W. M.; Watanabe, H.; Du, W.; Fan, J.; Diaz, B.; Lin, H. V.; Leibel, R. L.; Belvedere, S.; Accili, D.
10.1101/2021.12.07.471572 — developmental biology — Posted on 2022-07-20
1353 Cas9+ conditionally immortalized neutrophil progenitors as a tool for genome wide CRISPR screening for neutrophil differentiation and function
Jong, R. M.; Ching, K.; Garelis, N. E.; Zilinskas, A.; Nguyenla, X.; Rawal, S.; Hill, B.; Luckie, B.; Shallow, L.; Cox, J. S.; Barton, G.; Stanley, S.
10.1101/2022.07.19.500665 — immunology — Posted on 2022-07-20
1359 Long range allostery mediates the regulation of plasminogen activator inhibitor 1 by vitronectin
Kihn, K.; Marchiori, E.; Spagnolli, G.; Boldrini, A.; Terruzzi, L.; Lawrence, D. A.; Gershenson, A.; Faccioli, P.; Wintrode, P. L.
10.1101/2022.07.19.500692 — biophysics — Posted on 2022-07-20
1362 Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade
Hassan, J.; Appleton, E.; Kalfaoglu, B.; Pedersen, M.; Almeida-Santos, J.; Kanemaru, H.; Irie, N.; Foo, S.; Reda, O.; Tan, B. J. Y.; Okazaki, I.-m.; Okazaki, T.; Satou, Y.; Harrington, K.; Melcher, A.; Ono, M.
10.1101/2022.07.19.500582 — immunology — Posted on 2022-07-20
1363 Molecular and spatial profiling of the paraventricular nucleus of the thalamus
Gao, C.; Gohel, C. A.; Leng, Y.; Goldman, D.; Levine, A. J.; Penzo, M. A.
10.1101/2022.07.19.500649 — neuroscience — Posted on 2022-07-20
1364 Dopamine Activates Astrocytes in Prefrontal Cortex via α1-Adrenergic Receptors
Pittolo, S.; Yokoyama, S.; Willoughby, D.; Taylor, C.; Reitman, M.; Tse, V.; Wu, Z.; Etchenique, R.; Li, Y.; Poskanzer, K. E.
10.1101/2022.07.19.500710 — neuroscience — Posted on 2022-07-20
1366 FDA-approved carbonic anhydrase inhibitors reduce Amyloid beta pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness
Canepa, E.; Parodi-Rullan, R.; Vazquez-Torres, R.; Gamallo-Lana, B.; Guzman-Hernandez, R.; Lemon, N. L.; Angiulli, F.; Debure, L.; Ilies, M.; Ostergaard, L.; Wisniewski, T.; Gutierrez-Jimenez, E.; Mar, A.; Fossati, S.
10.1101/2022.07.19.500681 — neuroscience — Posted on 2022-07-20
1370 Contrasting and conserved roles of NPR proteins in diverged land plant lineages
Jeon, H.-W.; Iwakawa, H.; Naramoto, S.; Herrfurth, C.; Gutsche, N.; Schlueter, T.; Kyozuka, J.; Miyauchi, S.; Feussner, I.; Zachgo, S.; Nakagami, H.
10.1101/2022.07.19.500630 — plant biology — Posted on 2022-07-20
1371 The Piks allele of the NLR immune receptor Pik breaks the recognition of AvrPik effectors of the rice blast fungus
Xiao, G.; Wang, W.; Liu, M.; Li, Y.; Liu, J.; Franceschetti, M.; Yi, Z.; Zhu, X.; Zhang, Z.; Lu, G.; Banfield, M. J.; Wu, J.; Zhou, B.
10.1101/2022.07.19.500709 — plant biology — Posted on 2022-07-20
1372 Tangled gene-for-gene interactions mediate co-evolution of the rice NLR immune receptor Pik and blast fungus effector proteins
Sugihara, Y.; Abe, Y.; Takagi, H.; Abe, A.; Shimizu, M.; Ito, K.; Kanzaki, E.; Oikawa, K.; Kourelis, J.; Langner, T.; Win, J.; Bialas, A.; Ludke, D.; Chuma, I.; Saitoh, H.; Kobayashi, M.; Zheng, S.; Tosa, Y.; Banfield, M. J.; Kamoun, S.; Terauchi, R.; Fujisaki, K.
10.1101/2022.07.19.500555 — plant biology — Posted on 2022-07-20
1377 MicroRNA-mRNA networks are dysregulated in opioid use disorder postmortem brain: further evidence for opioid-induced neurovascular alterations
Grimm, S. L.; Mendez, E. F.; Stertz, L.; Meyer, T. D.; Fries, G. R.; Gandhi, T.; Kanchi, R.; Selvaraj, S.; Teixeira, A. L.; Kosten, T.; Gunaratne, P.; Coarfa, C.; Walss-Bass, C.
10.1101/2022.07.19.500679 — bioinformatics — Posted on 2022-07-20
1378 Tissue-Restricted Inhibition of mTOR Using Chemical Genetics
Wassarman, D. R.; Bankapalli, K.; Pallanck, L. J.; Shokat, K. M.
10.1101/2022.03.08.483534 — biochemistry — Posted on 2022-07-20
1379 Fixing reference errors efficiently improves sequencing results
Behera, S.; LeFaive, J.; Orchard, P.; Mahmoud, M.; Paulin, L. F.; Farek, J.; Soto, D. C.; Parker, S. C. J.; Smith, A. V.; Dennis, M. Y.; Zook, J. M.; Sedlazeck, F. J.
10.1101/2022.07.18.500506 — genomics — Posted on 2022-07-20
1382 The antique genetic plight of the Mediterranean monk seal (Monachus monachus)
Salmona, J.; Dayon, J.; Lecompte, E.; Karamanlidis, A. A.; Aguilar, A.; Fernandez de Larrinoa, P.; Pires, R.; Mo, G.; Panou, A.; Agnesi, A.; Borrell, A.; Danyer, E.; Öztürk, B.; Tonay, A. M.; Anestis, A. K.; Gonzalez, L. M.; Dendrinos, P.; Gaubert, P.
10.1101/2021.12.23.473149 — genetics — Posted on 2022-07-20
1385 West Nile virus and Usutu virus in wild birds from Rescue Centers, a post-mortem monitoring study from Central Italy.
Giglia, G.; Mencattelli, G.; Lepri, E.; Agliani, G.; Gobbi, M.; Groene, A.; van den Brand, J. M. A.; Savini, G.; Mandara, M. T.
10.1101/2022.07.19.500416 — microbiology — Posted on 2022-07-20
1386 Human Galectin-9 Promotes the Expansion of HIV Reservoirs in vivo in Humanized Mice
Yuan, Z.; Giron, L. B.; Hart, C.; Gyampoh, A.; Koshy, J.; Hong, K. Y.; Niki, T.; Premeaux, T. A.; Ndhlovu, L. C.; Montaner, L. J.; Abdel-Mohsen, M.
10.1101/2022.07.19.500638 — microbiology — Posted on 2022-07-20
1387 Dynamic mitochondrial transcription and translation in B cells control germinal centre entry and lymphomagenesis
Yazicioglu, Y. F.; Marin, E. M.; Galiani, S.; Compeer, E.; Sandhu, C.; Attar, M.; Dustin, M.; Clarke, A.
10.1101/2022.07.19.500689 — immunology — Posted on 2022-07-20
1388 Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA
Hur, S.; Paget, M.; Cadena, C.; Ahmad, S.; Wang, H.; Jordan, T.; Kim, E.; Zhang, Q.; Koo, B.; Lyons, S.; Ivanov, P.; tenOever, B.; Mu, X.
10.1101/2021.04.26.441141 — immunology — Posted on 2022-07-20
1389 Updating memories of unwanted emotions during human sleep
Xia, T.; Yao, Z.; Guo, X.; Liu, J.; Chen, D.; Liu, Q.; Ken, P. A.; Hu, X.
10.1101/2022.07.18.500414 — neuroscience — Posted on 2022-07-20
1390 A physical neural mass model framework for the analysis of oscillatory generators from laminar electrophysiological recordings
Sanchez-Todo, R.; Bastos, A.; Lopez-Sola, E.; Mercadal, B.; Santarnecchi, E.; Miller, E. K.; Deco, G.; Ruffini, G.
10.1101/2022.07.19.500618 — neuroscience — Posted on 2022-07-20
1391 Class imbalance should not throw you off balance: Choosing classifiers and performance metrics for brain decoding with imbalanced data
Thölke, P.; Ramos, Y. J. M.; Abdelhedi, H.; Maschke, C.; Dehgan, A.; Harel, Y.; Kemtur, A.; Berrada, L. M.; Sahraoui, M.; Young, T.; Hadid, V.; Combrisson, E.; O'Byrne, J.; Jerbi, K.
10.1101/2022.07.18.500262 — neuroscience — Posted on 2022-07-20
1392 Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer's Disease
Bubak, A. N.; Merle, L.; Niemeyer, C. S.; Baxter, D. B.; Polese, A. G.; Ramakrishnan, V.; Gomez, J.; Madrigal, L.; Villegas-Lanau, A.; Lopera, F.; Macklin, W.; Frietze, S.; Nagel, M. A.; Restrepo, D.
10.1101/2022.07.19.500641 — neuroscience — Posted on 2022-07-20
1393 Oral oxycodone self-administration leads to features of opioid addiction in male and female mice
Slivicki, R.; Earnest, T.; Chang, Y.-H.; Pareta, R.; Casey, E.; Li, J.-N.; Tooley, J.; Abiraman, K.; Vachez, Y. M.; Wolf, D. K.; Sackey, J. T.; Gereau, R.; Copits, B. A.; Kravitz, A. V.; Creed, M. C.
10.1101/2022.07.19.500655 — neuroscience — Posted on 2022-07-20
1394 The Interictal Suppression Hypothesis in Focal Epilepsy: Electrographic and Structural Evaluation
Johnson, G. W.; Doss, D. J.; Morgan, V. L.; Paulo, D. L.; Cai, L. Y.; Shless, J. S.; Negi, A. S.; Gummadavelli, A.; Kang, H.; Reddy, S. B.; Naftel, R. P.; Bick, S. K.; Roberson, S. W.; Dawant, B. M.; Wallace, M. T.; Englot, D. J.
10.1101/2022.06.27.497765 — neuroscience — Posted on 2022-07-20
1396 In colon cancer cells, fascin1 functions as a mechanosensor that transforms adherens junction mechanotransduction.
Esmaeilniakooshkghazi, A.; Pham, E.; George, S. P.; Ahrorov, A.; Villagomez, F. R.; Byington, M.; Mukhopadhyay, S.; Patnaik, S.; Conrad, J. C.; Naik, M.; Ravi, S.; Tebbuttt, N.; Mooi, J.; Reehorst, C. M.; Mariadason, J. M.; Khurana, S.
10.1101/2022.06.14.496198 — cancer biology — Posted on 2022-07-20
1398 Slow integrin-dependent migration organizes networks of tissue-resident mast cells
Bambach, S. K.; Kaltenbach, L.; Aizarani, N.; Martzloff, P.; Gavrilov, A.; Glaser, K. M.; Thünauer, R.; Mihlan, M.; Stecher, M.; Thiriot, A.; Wienert, S.; von Andrian, U. H.; Schmidt-Supprian, M.; Nerlov, C.; Klauschen, F.; Roers, A.; Bajenoff, M.; Grün, D.; Lämmermann, T.
10.1101/2022.07.19.500614 — cell biology — Posted on 2022-07-20
1399 Adipocyte-secreted IL-6 sensitizes macrophages to IL-4 signaling
Luan, D. A.; Dadpey, B.; Zaid, J.; De Luca, J. H.; Xia, W.; Castle, J.; Reilly, S. M.
10.1101/2022.07.19.500620 — immunology — Posted on 2022-07-20
1401 Age-related Macular Degeneration is associated with faster rates of structural brain changes and widespread differences in connectivity
Stout, J. A.; Dai, R. A.; Anderson, R. B.; Cousins, S. W.; Zhuang, J.; Lad, E. M.; Whitaker, D. B.; Madden, D. J.; Potter, G. G.; Whitson, H. E.; Badea, A.
10.1101/2022.07.19.500546 — neuroscience — Posted on 2022-07-20
1402 Menstrual cycle and exogenous attention toward emotional expressions
Alvarez, F.; Fernandez-Folgueiras, U.; Mendez-Bertolo, C.; Kessel, D.; Carretie, L.
10.1101/2022.07.19.500437 — neuroscience — Posted on 2022-07-20
1403 NeuVue: A Framework and Workflows for High-Throughput Electron Microscopy Connectomics Proofreading
Xenes, D.; Kitchell, L. M.; Rivlin, P. K.; Brodsky, R.; Gooden, H.; Joyce, J.; Luna, D.; Norman-Tenazas, R.; Ramsden, D.; Romero, K.; Rose, V.; Villafane-Delgado, M.; Gray-Roncal, W.; Wester, B.
10.1101/2022.07.18.500521 — neuroscience — Posted on 2022-07-20
1404 Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies
Engdahl, T. B.; Binshtein, E.; Brocato, R. L.; Kuzmina, N. A. A.; Principe, L. M.; Kwilas, S. A.; Kim, R. K.; Chapman, N. S.; Porter, M. S.; Guardado-Calvo, P.; Rey, F. A.; Handal, L. S.; Diaz, S. M.; Zagol-Ikapitte, I. A.; Reidy, J. X.; Trivette, A.; Bukreyev, A.; Hooper, J. W.; Crowe, J. E.
10.1101/2022.07.19.500579 — immunology — Posted on 2022-07-20
1406 Neuroanatomical and Functional Consequences of Oxytocin Treatment at Birth
Kenkel, W.; Ortiz, R.; Yee, J. R.; Perkeybile, A. M.; Kulkarni, P.; Carter, C. S.; Cushing, B. S.; Ferris, C. F.
10.1101/2022.05.21.492438 — neuroscience — Posted on 2022-07-20
1407 Visual stimuli modulate local field potentials but drive no high-frequency activity in human auditory cortex
Ahveninen, J.; Lee, H.-J.; Yu, H.-Y.; Lee, C.-C.; Chou, C.-C.; Ahlfors, S. P.; Kuo, W.-J.; Jääskeläinen, I. P.; Lin, F.-H.
10.1101/2022.07.18.500417 — neuroscience — Posted on 2022-07-20
1408 Standing balance is not affected by estrogen fluctuations during the menstrual cycle
Reschechtko, S.; Nguyen, T. N.; Tsang, M.; Giltvedt, K.; Kern, M.; Hooshmand, S.
10.1101/2022.07.18.500469 — physiology — Posted on 2022-07-20
1411 Molecular Transport of the Zika Virus by the Human Cytoplasmic Dynein-1
Zavala-Vargas, D. I.; Carbajal, G. V.; Cedillo-Barron, L.; Filisola-Villasenor, J. G.; Ramirez, R. R.; Ludert, J. E.; Morales-Rios, E.
10.1101/2022.06.15.496315 — biochemistry — Posted on 2022-07-20
1413 Herbaceous production lost to tree encroachment in United States rangelands.
Morford, S. L.; Allred, B. W.; Twidwell, D.; Jones, M. O.; Maestas, J. D.; Roberts, C. P.; Naugle, D. E.
10.1101/2021.04.02.438282 — ecology — Posted on 2022-07-20
1414 A unique H2B acetylation signature marks active enhancers and predicts their target genes
Narita, T.; Higashijima, Y.; Kilic, S.; Liebner, T.; Walter, J.; Choudhary, C.
10.1101/2022.07.18.500459 — genomics — Posted on 2022-07-20
1415 Septins Enable T Cells Adaptive Circumnavigation and Migration-Transmigration Transition Within Structurally Complex Microenvironments
Zhovmer, A. S.; Manning, A.; Smith, C.; Vishweshwaraiah, Y. L.; Wang, J.; Saez, P. J.; Ma, X.; Tsygankov, D.; Cartagena-Rivera, A. X.; Singh, R. K.; Dokholyan, N. V.; Tabdanov, E. D.
10.1101/2022.01.18.476840 — biophysics — Posted on 2022-07-20
1419 Compositional profiling of extracellular vesicles/lipoproteins mixtures by AFM nanomechanical imaging
Ridolfi, A.; Conti, L.; Brucale, M.; Frigerio, R.; Cardellini, J.; Musico, A.; Romano, M.; Zendrini, A.; Polito, L.; Bergamaschi, G.; Gori, A.; Montis, C.; Barile, L.; Berti, D.; Radeghieri, A.; Bergese, P.; Cretich, M.; Valle, F.
10.1101/2022.07.19.500441 — biophysics — Posted on 2022-07-20
1420 Operationalizing climate risk in a global warming hotspot
Boyce, D. G.; Tittensor, D. P.; Fuller, S.; Henson, S.; Kaschner, K.; Reygondeau, G.; Schleit, K. E.; Saba, V.; Shackell, N.; Stanley, R.; Worm, B.
10.1101/2022.07.19.500650 — ecology — Posted on 2022-07-20
1421 Tecovirimat is highly efficient on the Monkeypox virus lineage responsible for the international 2022 outbreak
Frenois-Veyrat, G.; Gallardo, F.; Gorge, O.; Marcheteau, E.; Ferraris, O.; Baidaliuk, A.; Favier, A.-L.; Enfroy, C.; Holy, X.; Lourenco, J.; Khoury, R.; Nolent, F.; Grosenbach, D. W.; Hruby, D.; Ferrier, A.; Iseni, F.; Simon-Loriere, E.; Tournier, J.-N.
10.1101/2022.07.19.500484 — microbiology — Posted on 2022-07-20
1422 Geneticin shows selective antiviral activity against SARS-CoV-2 by interfering with programmed -1 ribosomal frameshifting
Varricchio, C.; Mathez, G.; Pillonel, T.; Bertelli, C.; Kaiser, L.; Tapparel, C.; Brancale, A.; Cagno, V.
10.1101/2022.03.08.483429 — microbiology — Posted on 2022-07-20
1426 Pervasive Transcriptome Interactions of Protein-Targeted Drugs
Fang, L.; Velema, W. A.; Lee, Y.; Xiao, L.; Mohsen, M. G.; Kietrys, A. M.; Kool, E. T.
10.1101/2022.07.18.500496 — pharmacology and toxicology — Posted on 2022-07-20
1428 Deep generative modeling and clustering of single cell Hi-C data
Liu, Q.; Zeng, W.; Zhang, W.; Wang, S.; Chen, H.; Jiang, R.; Zhou, M.; Zhang, S.
10.1101/2022.07.19.500573 — bioinformatics — Posted on 2022-07-20
1431 Imputation of ancient genomes
Sousa da Mota, B.; Rubinacci, S.; Cruz Davalos, D. I.; G. Amorim, C. E.; Sikora, M.; Johannsen, N. N.; Szmyt, M. H.; Włodarcza, P.; Szczepanek, A.; Przybyła, M. M.; Schroeder, H.; Allentoft, M. E.; Willerslev, E.; Malaspinas, A.-S.; Delaneau, O.
10.1101/2022.07.19.500636 — genomics — Posted on 2022-07-20
1433 Enterobacterales-associated plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches: a genomic surveillance study in Oxfordshire, UK
Matlock, W.; Lipworth, S.; Chau, K. K.; AbuOun, M.; Barker, L.; Kavanagh, J.; Andersson, M.; Oakley, S.; Morgan, M.; Crook, D. W.; Read, D. S.; Anjum, M.; Shaw, L. P.; Stoesser, N.; REHAB Consortium,
10.1101/2022.05.06.490774 — genomics — Posted on 2022-07-20
1434 ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells
Xu, W.; Yang, W.; Zhang, Y.; Chen, Y.; Hong, N.; Zhang, Q.; Wang, X.; Hu, Y.; Song, K.; Jin, W.; Chen, X.
10.1101/2022.01.16.476488 — genomics — Posted on 2022-07-20
1438 WNT stimulation induced conformational dynamics in the Frizzled-Dishevelled interaction
Bowin, C.-F.; Kozielewicz, P.; Graetz, L.; Kowalski-Jahn, M.; Schihada, H.; Schulte, G.
10.1101/2022.07.19.500578 — pharmacology and toxicology — Posted on 2022-07-20
1446 Free-Standing Multilayer Films as Growth Factor Reservoirs for Future Wound Dressing Applications
Hautmann, A.; Kedilaya, D.; Stojanovic, S.; Radenkovic, M.; Marx, C. K.; Najman, S.; Pietzsch, M.; Mano, J. F.; Groth, T.
10.1101/2022.07.19.500607 — bioengineering — Posted on 2022-07-20
1447 A home-cage, video monitoring-based mouse frailty index detects age-associated morbidity in the absence of handler-induced stress.
Ruby, J. G.; Ylagan, P.; Di Francesco, A.; Zavala-Solorio, J.; Keyser, R.; Williams, O.; Spock, S.; Li, W.; Vongtharangsy, N.; Chatterjee, S.; Sloan, C. A.; Ledogar, C.; Kuiper, V.; Kite, J.; Cosino, M.; Cha, P.; Karlsson, E. M.
10.1101/2022.07.19.500666 — animal behavior and cognition — Posted on 2022-07-20
1448 Multiset correlation and factor analysis enables exploration of multi-omic data
Brown, B. C.; Wang, C. L.; Kasela, S.; Aguet, F.; Nachun, D. C.; Taylor, K. D.; Tracy, R. P.; Durda, P.; Lui, Y.; Johnson, W. C.; Van Den Berg, D.; Gupta, N.; Gabriel, S.; Smith, J. D.; Gerzten, R.; Clish, C.; Wong, Q.; Papanicolau, G.; Blackwell, T. W.; Rotter, J. I.; Rich, S. S.; Ardlie, K. G.; Knowles, D. A.; Lappalainen, T.
10.1101/2022.07.18.500246 — genomics — Posted on 2022-07-20
1449 Fixing reference errors efficiently improves sequencing results
Sedlazeck, F. J.; Zook, J. M.; Dennis, M. Y.; Behera, S.; LeFaive, J.; Orchard, P.; Mahmoud, M.; Paulin, L. F.; Farek, J.; Soto, D. C.; Parker, S. C. J.; Smith, A. V.
10.1101/2022.07.18.500506 — genomics — Posted on 2022-07-20
1452 Group 3 Innate Lymphoid Cells are regulated by WASP in a microbiota-dependent manner
Biswas, A.; Redhu, N. S.; Nandy, A.; Kang, Y. H.; Field, M.; Kelly, R.; Konnikova, L.; Goettel, J.; Tsou, A.; Horwitz, B.; Snapper, S.
10.1101/2022.07.19.500438 — immunology — Posted on 2022-07-20
1454 S100a9 Attenuates Inflammation during Repeated Social Defeat Stress
Moshfegh, C. M.; Elkhatib, S. K.; Watson, G. F.; Drake, J.; Taylor, Z. N.; Reed, E. C.; Lauten, T. H.; Clopp, A. J.; Vladimirov, V. I.; Case, A. J.
10.1101/2022.07.18.500493 — immunology — Posted on 2022-07-20
1455 Glucocorticoid signaling mediates CD8+ T cell memory differentiation
Tehseen, A.; Kumar, D.; Sarkar, R.; Singh, S.; Dubey, A.; Sehrawat, S.
10.1101/2022.07.19.500581 — immunology — Posted on 2022-07-20
1456 Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior
Brockway, D. F.; Moyer, J. B.; Aloimonos, C. M.; Clarity, T.; Griffith, K. R.; Smith, G. C.; Dao, N. C.; Hossain, M. S.; Drew, P. J.; Gordon, J. A.; Kupferschmidt, D. A.; Crowley, N. A.
10.1101/2022.07.18.499817 — neuroscience — Posted on 2022-07-20
1458 Versatile Multiple Object Tracking in Sparse 2D/3D Videos Via Diffeomorphic Image Registration
Yu, J.; Nejatbakhsh, A.; Torkashvand, M.; Gangadharan, S.; Seyedolmohadesin, M.; Kim, J.; Paninski, L.; Venkatachalam, V.
10.1101/2022.07.18.500485 — neuroscience — Posted on 2022-07-20
1460 MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice
Rossi, G.; Ordazzo, G.; Vanni, N. N.; Castoldi, V.; Iannielli, A.; Di Silvestre, D.; Bellini, E.; Bernardo, L.; Giannelli, S. G.; Muggeo, S.; Mauri, P.; Letizia, L.; Broccoli, V.
10.1101/2022.07.18.500452 — neuroscience — Posted on 2022-07-20
1461 Evaluation of acaricidal activity of lithium-chloride against Tetranychus urticae (Acari: Tetranychidae)
Solti, I.; Kolics-Horvath, E.; Keszthelyi, S.; Bacsi, Z.; Staszny, A.; Nagy, E.; Taller, J.; Matyas, K.; Kolics, B.
10.1101/2022.07.19.500612 — zoology — Posted on 2022-07-20
1465 Epinephrine inhibits PI3K alpha via the Hippo kinases.
Lin, T.-Y.; Ramsamooj, S.; Liberatore, K.; Lantier, L.; Vasan, N.; Karukurichi, K.; Hwang, S.-K.; Kesicki, E. A.; Kastenhuber, E. R.; Wiederhold, T.; Yaron, T. M.; Zhu, M.; Ma, Y.; Paddock, M. N.; Zhang, G.; Hopkins, B. D.; McGuinness, O.; Schwartz, R. E.; Cantley, L. C.; Johnson, J. L.; Goncalves, M. D.
10.1101/2022.07.19.500601 — physiology — Posted on 2022-07-20
1472 FastCAR: Fast Correction for Ambient RNA to facilitate differential gene expression analysis in single-cell RNA-sequencing datasets
Berg, M.; Petoukhov, I.; van den Ende, I.; Meyer, K. B.; Guryev, V.; Vonk, J. M.; Carpaij, O. A.; Banchero, M.; Hendriks, R. W.; Van Den Berge, M.; Nawijn, M. C.
10.1101/2022.07.19.500594 — bioinformatics — Posted on 2022-07-20
1476 An automated pipeline for extracting quantitative histological metrics for voxelwise MRI-histology comparisons
Kor, D. Z. L.; Jbabdi, S.; Huszar, I. N.; Mollink, J.; Tendler, B. C.; Foxley, S.; Wang, C.; Scott, C.; Smart, A.; Ansorge, O.; Pallebage-Gamarallage, M.; Miller, K. L.; Howard, A. F. D.
10.1101/2022.02.10.479718 — neuroscience — Posted on 2022-07-20
1478 A novel fold for acyltransferase-3 (AT3) proteins provides a framework for transmembrane acyl-group transfer
Newman, K. E.; Tindall, S. N.; Mader, S. L.; Khalid, S.; Thomas, G. H.; Van der Woude, M. W.
10.1101/2022.06.30.498268 — biochemistry — Posted on 2022-07-20
1480 Building bridges from genome to physiology using machine learning and Drosophila experimental evolution
Kezos, J. N.; Barter, T. T.; Cabral, L.; Phillips, M. A.; Azatian, G.; Buenrostro, J. E.; Bhangoo, P. S.; Khong, A.; Reyes, G. T.; Rahman, A.; Humphrey, L. A.; Bradley, T. J.; Mueller, L. D.; Rose, M. R.
10.1101/2022.07.18.500543 — physiology — Posted on 2022-07-20
1481 Histone demethylome map reveals combinatorial gene regulatory functions in embryonic stem cells
Kumar, Y.; Tripathi, P.; Dakle, P.; Mehravar, M.; Pandey, V. K.; Bullen, M. J.; Zhang, Z.; Hathiwala, D.; Kerenyi, M.; Woo, A.; Ghamari, A.; Cantor, A. B.; Wong, L. H.; Kim, J.; Glass, K.; Yuan, G.-C.; Pinello, L.; Orkin, S. H.; Das, P. P.
10.1101/2020.08.27.269514 — genomics — Posted on 2022-07-20
1484 Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB
Plaza-G.A., I.; Lemishko, K. M.; Crespo, R.; Truong, T. Q.; Kaguni, L. S.; Cao-Garcia, F. J.; Ciesielski, G. L.; Ibarra, B.
10.1101/2022.07.19.500644 — biophysics — Posted on 2022-07-20
1485 Site-specific Halogenation of Peptides and Proteins using engineered Halogenase Enzymes
Sana, B.; Ke, D.; Li, E. H. Y.; Ho, T.; Seayad, J.; Duong, H. A.; Ghadessy, F.
10.1101/2022.07.19.500721 — biochemistry — Posted on 2022-07-20
1486 Deep mutational scanning and massively parallel kinetics of plasminogen activator-1 functional stability
Haynes, L. M.; Huttinger, Z. M.; Yee, A.; Kretz, C. A.; Siemieniak, D. R.; Lawrence, D. A.; Ginsburg, D.
10.1101/2022.07.19.500671 — biochemistry — Posted on 2022-07-20
1487 Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY
Kim, C. Y.; Mitchell, A. J.; Kastner, D. W.; Albright, C. E.; Gutierrez, M.; Glinkerman, C. M.; Kulik, H. J.; Weng, J.-K.
10.1101/2022.07.19.500703 — biochemistry — Posted on 2022-07-20
1488 Comprehensive analysis of platelet glycoprotein Ibα glycosylation.
Hollenhorst, M. A.; Tiemeyer, K. H.; Mahoney, K. E.; Aoki, K.; Ishihara, M.; Lowery, S. C.; Rangel-Angarita, V.; Bertozzi, C. R.; Malaker, S. A.
10.1101/2022.07.19.500646 — biochemistry — Posted on 2022-07-20
1489 MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state
Mehravar, M.; Kumar, Y.; Olshansky, M.; Dakle, P.; Bullen, M. J.; Pandey, V. K.; Bansal, D.; Dent, C.; Hathiwala, D.; Zhang, Z.; Gandhi, H.; Fulcher, A.; Huang, C.; Price, J.; Arumugam, S.; Ceman, S.; Balasubramanian, S.; Papas, B. N.; Morgan, M.; Miska, E. A.; Schittenhelm, R. B.; Tripathi, P.; Das, P. P.
10.1101/2021.08.11.456030 — biochemistry — Posted on 2022-07-20
1491 The contribution of sex chromosome conflict to disrupted spermatogenesis in hybrid house mice
Kopania, E. E. K.; Watson, E. M.; Rathje, C. C.; Skinner, B. M.; Ellis, P. J.; Larson, E. L.; Good, J. M.
10.1101/2022.07.19.499960 — evolutionary biology — Posted on 2022-07-20
1495 Formulation of FMD vaccine in Naloxone/Alum mixture: A potency study
Alemalhoda, D.; Ajamian, F.; Khorasani, A.; Haghighat, S.; Mahdavi Amreie, M.; Sarkeshikzadeh Moghadas, F. S.; Asgarhalvaei, F.; Kalantari, A.; Mahdavi, M.
10.1101/2022.07.19.500605 — molecular biology — Posted on 2022-07-20
1498 Is there a placental microbiota? A critical review and re-analysis of published placental microbiota datasets
Panzer, J.; Romero, R.; Greenberg, J. M.; Winters, A. D.; Galaz, J.; Gomez-Lopez, N.; Theis, K. R.
10.1101/2022.07.18.500562 — microbiology — Posted on 2022-07-20
1499 CDPK2A and CDPK1 form a signaling module upstream of Toxoplasma motility
Shortt, E.; Hackett, C. G.; Stadler, R. V.; WARD, G. E.; Lourido, S.
10.1101/2022.07.19.500742 — microbiology — Posted on 2022-07-20
1501 Human Galectin-9 Promotes the Expansion of HIV Reservoirs in vivo in Humanized Mice
Yuan, Z.; Giron, L. B.; Hart, C.; Gyampoh, A.; Koshy, J.; Hong, K. Y.; Niki, T.; Premeaux, T. A.; Ndhlovu, L. C.; Abdel-Mohsen, M.
10.1101/2022.07.19.500638 — microbiology — Posted on 2022-07-20
1504 Bacterial NLR-related proteins protect against phage
Kibby, E. M.; Conte, A. N.; Burroughs, A. M.; Nagy, T. A.; Vargas, J. A.; Aravind, L.; Whiteley, A. T.
10.1101/2022.07.19.500537 — microbiology — Posted on 2022-07-20
1505 A vast world of viroid-like circular RNAs revealed by mining metatranscriptomes
Lee, B. D.; Neri, U.; Roux, S.; Wolf, Y. I.; Camargo, A. P.; Krupovic, M.; Simmonds, P.; Kyrpides, N.; Gophna, U.; Dolja, V. V.; Koonin, E. V.
10.1101/2022.07.19.500677 — microbiology — Posted on 2022-07-20
1509 Potent Bacterial Vaccines Require FcγRIIB-mediated Pathogen Capture by Liver Sinusoidal Endothelium
Wang, J.; An, H.; Ding, M.; Liu, Y.; Wang, S.; Jin, Q.; Dong, H.; Tian, X.; Liu, J.; Zhang, J.; Zhu, T.; Li, J.; Shao, Z.; Briles, D. E.; Zheng, H.; Zhang, L.; Zhang, J.-R.
10.1101/2022.07.19.500551 — immunology — Posted on 2022-07-20
1510 CRI-SPA, a mating based CRISPR-Cas9 assisted method for high-throughput genetic modification of yeast strain libraries
Mortensen, U. H.; Olsson, H.; Cachera, P. P.-Y. J.; Coumou, H.; Jensen, M. L.; Sanchez, B. J.; Strucko, T.; van den Broek, M.; Daran, J.-M.; Jensen, M. K.; Sonnenschein, N.; Lisby, M.
10.1101/2022.07.19.500587 — systems biology — Posted on 2022-07-20
1512 Density dependent environments can select for extremes of body size
Coulson, T.; Felmy, A.; Potter, T.; Passoni, G.; Montgomery, R. A.; Gaillard, J.-M.; Hudson, P. J.; Travis, J.; Bassar, R. D.; Tuljapurkar, S. D.; Marshall, D.; Clegg, S. M.
10.1101/2022.02.17.480952 — evolutionary biology — Posted on 2022-07-19
1513 mTORC2 couples fasting to mitochondrial fission
Martinez-Lopez, N.; Mattar, P.; Toledo, M.; Bains, H.; Kalyani, M.; Aoun, M. L.; Sharma, M.; McIntyre, L. B. J.; Gunther-Cummins, L.; Macaluso, F. P.; Aguilan, J. T.; Sidoli, S.; Bourdenx, M.; Singh, R.
10.1101/2022.07.19.500669 — cell biology — Posted on 2022-07-20
1514 Mitotic clustering of pulverized chromosomes from micronuclei
Lin, Y.-F.; Valle-Inclan, J. E.; Mazzagatti, A.; Hu, Q.; Maurais, E. G.; Guyer, A.; Sanders, J. T.; Engel, J.; Nguyen, G.; Bronder, D.; Bakhoum, S. F.; Cortes-Ciriano, I.; Ly, P.
10.1101/2022.07.19.500697 — cell biology — Posted on 2022-07-20
1516 Two point mutations in protocadherin-1 disrupt Andes hantavirus recognition and afford protection against lethal infection
Slough, M. M.; Li, R.; Herbert, A. S.; Lasso, G.; Kuehne, A. I.; Bakken, R. R.; Monticelli, S. R.; Liu, Y.; Ghosh, A.; Moreau, A. M.; Zeng, X.; Almo, S. C.; Dye, J. M.; Jangra, R. K.; Wang, Z.; Chandran, K.
10.1101/2022.07.19.500682 — microbiology — Posted on 2022-07-20
1517 Persistence of SARS-CoV-2 neutralizing antibodies longer than 13 months in naturally-infected, captive white-tailed deer (Odocoileus virginianus), Texas
Hamer, S. A.; Nunez, C. M.; Roundy, C.; Tang, W.; Thomas, L. F.; Richison, J. J.; Benn, J.; Auckland, L.; Hensley, T.; Cook, W. E.; Pauvolid-Correa, A.; Hamer, G.
10.1101/2022.07.19.500662 — zoology — Posted on 2022-07-19
1518 Aeration Strategy at Birth Does Not Impact Carotid Blood Flow and Oxygen Delivery in Preterm Lambs
Dahm, S.; Kenna, K.; Stewart, D.; Pereira-Fantini, P.; McCall, K.; Perkins, E.; Sourial, M.; Tingay, D.
10.1101/2022.03.03.482754 — physiology — Posted on 2022-07-19
1519 Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection
Jalbert, E.; Liu, C.; Mave, V.; Lang, N.; Kagal, A.; Valvi, C.; Paradkar, M.; Gupte, N.; Lokhande, R.; Bharadwaj, R.; Kulkarni, V.; Gupta, A.; Weinberg, A.
10.1101/2022.06.13.495865 — immunology — Posted on 2022-07-19
1520 Highly fucosylated N-glycans at the synaptic vesicle and neuronal plasma membrane
Bradberry, M. M.; Peters-Clarke, T. M.; Shishkova, E.; Chapman, E. R.; Coon, J. J.
10.1101/2022.07.06.499060 — neuroscience — Posted on 2022-07-19
1523 High-plex Multiomic Analysis in FFPE at Subcellular Level by Spatial Molecular Imaging
He, S.; Bhatt, R.; Brown, C.; Brown, E. A.; Buhr, D. L.; Chantranuvatana, K.; Danaher, P.; Dunaway, D.; Garrison, R. G.; Geiss, G.; Gregory, M. T.; Hoang, M. L.; Khafizov, R.; Killingbeck, E. E.; Kim, D.; Kim, T. K.; Kim, Y.; Klock, A.; Korukonda, M.; Kutchma, A.; Lewis, Z. R.; Liang, Y.; Nelson, J. S.; Ong, G. T.; Perillo, E. P.; Phan, J. C.; Phan-Everson, T.; Piazza, E.; Rane, T.; Reitz, Z.; Rhodes, M.; Rosenbloom, A.; Ross, D.; Sato, H.; Wardhani, A. W.; Williams-Wietzikoski, C. A.; Wu, L.; Beechem, J. M.
10.1101/2021.11.03.467020 — genomics — Posted on 2022-07-19
1526 A Pan-respiratory Antiviral Chemotype Targeting a Transient Host Multiprotein Complex
Mueller-Schiffmann, A.; Michon, M.; Lingappa, A. F.; Yu, S. F.; Du, L.; Deiter, F.; Mallesh, S.; Crabtree, J.; Lingappa, U. F.; Macieik, A.; Mueller, L.; Ostermann, P. N.; Andree, M.; Adams, O.; Schaal, H.; Hogan, R. J.; Tripp, R. A.; Appiah, U.; Anand, S. K.; Campi, T. W.; Ford, M. J.; Reed, J. C.; Lin, J.; Akintunde, O.; Copeland, K.; Nichols, C.; Petrouski, E.; Moreira, A. R.; Jiang, I.-t.; DeYarman, N.; Broce, S.; Brown, I.; Segal, I.; Goldsmith, D.; Lau, S.; Hong, S.; Asundi, V.; Briggs, E. M.; Phyo, N. S.; Froehlich, M.; Onisko, B.; Matlack, K.; Dey, D.; Lingappa, J. R.; Prasad, M. D.; K
10.1101/2021.01.17.426875 — biochemistry — Posted on 2022-07-19
1527 Exocyst Inactivation in Urothelial Cells Disrupts Autophagy and Activates non-canonical NF-kB
Ortega, M. A.; Villiger, R. K.; Harrison-Chau, M.; Lieu, S.; Tamashiro, K.-K.; Lee, A. J.; Fujimoto, B. A.; Patwardhan, G. Y.; Kepler, J.; Fogelgren, B.
10.1101/2021.07.05.451173 — developmental biology — Posted on 2022-07-19
1529 MICOS Complex and Mitochondria Morphology Changes Across Aging in Cardiac Muscle
Vue, Z.; Neikirk, K.; Vang, L.; Garza Lopez, E.; Beasley, H.; Marshall, A.; Murray, S. A.; Hinton, A.
10.1101/2022.04.23.489291 — biophysics — Posted on 2022-07-19
1530 Mouse Skeletal Muscle Decrease in the MICOS Complex and Altered Mitochondrial Networks with age
Vue, Z.; Lopez, E. G.; Neikirk, K.; Vang, L.; Marshall, A. G.; Beasley, H.; Hinton, A.; Murray, S. A.
10.1101/2022.03.22.485341 — biophysics — Posted on 2022-07-19
1534 Chronic Jetlag Accelerates Pancreatic Neoplasia in Conditional Kras-Mutant Mice
Schwartz, P. B.; Walcheck, M. T.; Nukaya, M.; Pavelec, D. M.; Matkowskyj, K. A.; Ronnekleiv-Kelly, S. M.
10.1101/2022.07.18.500370 — cancer biology — Posted on 2022-07-19
1536 Single-molecule simultaneous profiling of DNA methylation and DNA-protein interactions with Nanopore-DamID
Cheetham, S. W.; Jafrani, Y. M. A.; Andersen, S. B.; Jansz, N.; Kindlova, M.; Ewing, A. D.; Faulkner, G. J.
10.1101/2021.08.09.455753 — genomics — Posted on 2022-07-19
1538 Neutralizing antibody evasion and receptor binding features of SARS-CoV-2 Omicron BA.2.75
Cao, Y.; Yu, Y.; Song, W.; Jian, F.; Yisimayi, A.; Yue, C.; Feng, R.; Wang, P.; Yu, L.; Zhang, N.; Wang, J.; Xiao, T.; An, R.; Wang, Y.; Wang, J.; Liu, L.; Yang, S.; Niu, X.; Gu, Q.; Shao, F.; Hao, X.; Jin, R.; Wang, X.; Wang, Y.; Xie, X. S.
10.1101/2022.07.18.500332 — immunology — Posted on 2022-07-19
1542 Nicotine-Related Beliefs Induce Dose-Dependent Responses in the Human Brain
Perl, O.; Shuster, A.; Heflin, M.; Na, S.; Kidwai, A.; Booker, N.; Putnam, W. C.; Fiore, V. G.; Gu, X.
10.1101/2022.07.15.500226 — neuroscience — Posted on 2022-07-19
1544 Distributional coding of associative learning within projection-defined populations of midbrain dopamine neurons
Avvisati, R.; Kaufmann, A.-K.; Young, C. J.; Portlock, G. E.; Cancemi, S.; Costa, R. P.; Magill, P. J.; Dodson, P. D.
10.1101/2022.07.18.500429 — neuroscience — Posted on 2022-07-19
1546 Standing balance is not affected by estrogen fluctuations during the menstrual cycle
Reschechtko, S.; Nguyen, T. N.; Tsang, M.; Giltvedt, K.; Kern, M.; Hooshmand, S.
10.1101/2022.07.18.500469 — physiology — Posted on 2022-07-19
1547 The First Geographic Identification by Country of Sustainable Mutations of SARS-COV-2 Sequence Samples: Worldwide Natural Selection Trends
Mahmanzar, m.; Houseini, S. T.; Rahimian, K.; Mikaeili Namini, A.; Gholamzad, A.; Tokhanbigli, S.; Mollapour Sisakht, M.; Farhadi, A.; Lee Kuehu, D.; Deng, Y.
10.1101/2022.07.18.500565 — bioinformatics — Posted on 2022-07-19
1549 Perfusable Apparatus For Thick-tissue Creation And Growth (patch) Of Cardiac Tissue
Mir, A.; Pitaktong, I.; He, J. Y.; Nurminsky, K.; Dunn, T.; Koljaka, S.; Dunn, O.; Ran, S.; Rodgers, D.; Wang, A.; Matsushita, H.; Hibino, N.; Shih, W.
10.1101/2022.07.18.500065 — bioengineering — Posted on 2022-07-19
1551 Fasting increases investment in soma upon refeeding at the cost of gamete quality in zebrafish
Ivimey-Cook, E. R.; Murray, D. S.; de Coriolis, J.-C.; Edden, N.; Immler, S.; Maklakov, A. A.
10.1101/2022.07.18.500454 — evolutionary biology — Posted on 2022-07-19
1552 MATEdb, a data repository of high-quality metazoan transcriptome assemblies to accelerate phylogenomic studies
Fernandez, R.; Tonzo, V.; Simon Guerrero, C.; Lozano-Fernandez, J.; Martinez-Redondo, G. I.; Balart-Garcia, P.; Aristide, L.; Eleftheriadi, K.; Vargas-Chavez, C.
10.1101/2022.07.18.500182 — evolutionary biology — Posted on 2022-07-19
1554 Discovering host protein interactions specific for SARS-CoV-2 RNA genome
Giambruno, R.; Zacco, E.; Ugolini, C.; Vandelli, A.; Mulroney, L.; D'Onghia, M.; Criscuolo, E.; Castelli, M.; Clementi, N.; Clementi, M.; Mancini, N.; Bonaldi, T.; Gustincich, S.; Leonardi, T.; Tartaglia, G. G.; Nicassio, F.
10.1101/2022.07.18.499583 — molecular biology — Posted on 2022-07-19
1555 Tecovirimat is highly efficient on the Monkeypox virus lineage responsible for the international 2022 outbreak
Frenois-Veyrat, G.; Gallardo, F.; Gorge, O.; Marcheteau, E.; Ferraris, O.; Baidaliuk, A.; Favier, A.-L.; Enfroy, C.; Holy, X.; Lourenco, J.; Khoury, R.; Nolent, F.; Grosenbach, D. W.; Hruby, D.; Ferrier, A.; Iseni, F.; Simon-Loriere, E.; Tournier, J.-N.
10.1101/2022.07.19.500484 — microbiology — Posted on 2022-07-19
1556 Monovalent and trivalent VSV-based COVID-19 vaccines elicit potent neutralizing antibodies and immunodominant CD8+ T cells against diverse SARS-CoV-2 variants
Parham, K. A.; Kim, G. N.; Saeedian, N.; Ninkov, M.; Richer, C. G.; Li, Y.; Wu, K.; Rashu, R.; Barr, S. D.; Arts, E. J.; Haeryfar, S. M. M.; Kang, C. Y.; Troyer, R. M.
10.1101/2022.07.19.500626 — immunology — Posted on 2022-07-19
1558 Stereotyped behavioral maturation and rhythmic quiescence in C. elegans embryos
Ardiel, E. L.; Lauziere, A.; Xu, S.; Harvey, B. J.; Christensen, R.; Nurrish, S.; Kaplan, J. M.; Shroff, H.
10.1101/2021.12.09.471955 — neuroscience — Posted on 2022-07-19
1562 Mouse Skeletal Muscle Decrease in the MICOS Complex and Altered Mitochondrial Networks with age
Vue, Z.; Lopez, E. G.; Neikirk, K.; Vang, L.; Marshall, A. G.; Beasley, H.; Hinton, A.
10.1101/2022.03.22.485341 — biophysics — Posted on 2022-07-19
1565 A comprehensive approach for artifact-free sample preparation and assessment of mitochondrial morphology in tissue and cultured cells
Hinton, A.; Katti, P.; Christensen, T. A.; Mungai, M.; Shao, J.; Zhang, L.; Trushin, S.; Alghanem, A.; Jaspersen, A.; Geroux, R. E.; Neikirk, K.; Biete, M.; Garza Lopez, E.; Vue, Z.; Beasley, H.; Marshall, A.; Bleck, C. K. E.; Hicsasmaz, I.; Murray, S. A.; Edmonds, R. A. C.; Dajles, A.; Koo, Y. D.; Bacevac, S.; Salisbury, J. L.; Pereira, R. O.; Glancy, B.; Trushina, E.; Abel, E. D.
10.1101/2021.06.27.450055 — cell biology — Posted on 2022-07-19
1568 Extended functional connectivity of convergent structural alterations among individuals with PTSD: A neuroimaging meta-analysis
Pankey, B. S.; Riedel, M. C.; Cowan, I.; Bartley, J. E.; Pintos Lobo, R.; Hill-Bowen, L. D.; Salo, T.; Musser, E. D.; Sutherland, M. T.; Laird, A. R.
10.1101/2022.04.07.487478 — neuroscience — Posted on 2022-07-19
1569 MICOS Complex and Mitochondria Morphology Changes Across Aging in Cardiac Muscle
Vue, Z.; Neikirk, K.; Garza Lopez, E.; Vang, L.; Beasley, H.; Crabtree, A.; Marshall, A.; Murray, S. A.; Hinton, A.
10.1101/2022.04.23.489291 — biophysics — Posted on 2022-07-19
1573 Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2.
Hall, J.; Hofmeister, E.; Ip, H.; Nashold, S.; Leon, A.; Malave, C.; Falendysz, E.; Rocke, T.; Carossino, M.; Balasuriya, U.; Knowles, S.
10.1101/2022.07.18.500430 — pathology — Posted on 2022-07-19
1574 Loss of mechanical homeostasis drives epithelial acinar eversion
Narayanan, V.; Purkayastha, P.; Yu, B.; Cabe, J. I.; Dickinson, R. B.; Conway, D. E.; Lele, T. P.
10.1101/2022.07.06.499064 — biophysics — Posted on 2022-07-19
1576 RNABSdb and 3plex enable deep computational investigation of triplex forming lncRNAs
Cicconetti, C.; Lauria, A.; Proserpio, V.; Tamburrini, A.; Maldotti, M.; Oliviero, S.; Molineris, I.
10.1101/2022.07.06.496678 — bioinformatics — Posted on 2022-07-19
1577 Genomewide basis for nitrogen use efficiency in contrasting genotypes of rice
Sharma, N.; Jaiswal, D. K.; Kumari, S.; Dash, G. K.; Panda, S.; Anandan, A.; Raghuram, N.
10.1101/2022.07.19.500654 — plant biology — Posted on 2022-07-19
1578 An iterative gene editing strategy broadens eIF4E1 genetic diversity in Solanum lycopersicum and generates resistance to several potyvirus isolates
Kuroiwa, K.; Danilo, B.; Perrot, L.; Thenault, C.; Veillet, F.; Delacote, F.; Duchateau, P.; Nogue, F.; Mazier, M.; Gallois, j.-l.
10.1101/2022.07.19.500569 — plant biology — Posted on 2022-07-19
1580 Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT
Benedyk, T. H.; Connor, V.; Caroe, E. R.; Shamin, M.; Svergun, D. I.; Deane, J. E.; Jeffries, C. M.; Crump, C. M.; Graham, S. C.
10.1101/2022.06.01.494398 — microbiology — Posted on 2022-07-19
1581 A translational MRI approach to validate acute axonal damage detection
Toschi, N.; Cerdan Cerda, A.; Treaba, C. A.; Barletta, V.; Herranz Muelas, E.; Mehndiratta, A.; Mainero, C.; De Santis, S.
10.1101/2022.04.27.489694 — neuroscience — Posted on 2022-07-19
1584 Corruption of DNA End-Joining in Mammalian Chromosomes by Progerin Expression
Joudeh, L. A.; DiCintio, A. J.; Ries, M. R.; Gasperson, A. S.; Griffin, K. E.; Robbins, V. P.; Bonner, M.; Nolan, S.; Black, E.; Waldman, A. S.
10.1101/2022.07.18.500488 — molecular biology — Posted on 2022-07-19
1587 S373P Mutation of Spike Protein in SARS-CoV-2 Stabilizes Omicron
Zheng, B.; Xiao, Y.; Tong, B.; Mao, Y.; Ge, R.; Tian, F.; Dong, X.; Zheng, P.
10.1101/2022.06.22.497114 — biophysics — Posted on 2022-07-19
1589 MoBIE: A Fiji plugin for sharing and exploration of multi-modal cloud-hosted big image data
Pape, C.; Meechan, K.; Moreva, E.; Schorb, M.; Chiaruttini, N.; Zinchenko, V.; Vergara, H.; Mizzon, G.; Moore, J.; Arendt, D.; Kreshuk, A.; Schwab, Y.; Tischer, C.
10.1101/2022.05.27.493763 — bioinformatics — Posted on 2022-07-19
1590 The C-terminal tail of CSNAP attenuates the CSN complex
Füzesi-Levi, M. G.; Ben-Nissan, G.; Listov, D.; Hayouka, Z.; Fleishman, S.; Sharon, M.
10.1101/2022.07.18.500399 — biochemistry — Posted on 2022-07-19
1593 In-depth study of tomato and weed viromes reveals undiscovered plant virus diversity in an agroecosystem
Rivarez, M. P. S.; Pecman, A.; Bacnik, K.; Maksimovic Carvalho Ferreira, O.; Vucurovic, A.; Seljak, G.; Mehle, N.; Gutierrez-Aguirre, I.; Ravnikar, M.; Kutnjak, D.
10.1101/2022.06.30.498278 — ecology — Posted on 2022-07-19
1594 Unveiling hidden eukaryotes: diversity of Endomyxa (Rhizaria) in coastal marine habitats
Berney, C.; Ciaghi, S.; Romac, S.; Mahe, F.; de Vargas, C.; Jaillon, O.; Kirchmair, M.; Bass, D.; Neuhauser, S.
10.1101/2022.07.18.500052 — microbiology — Posted on 2022-07-19
1599 Perturbation of protein homeostasis brings plastids at the crossroad between repair and dismantling
Tadini, L.; Jeran, N.; Domingo, G.; Zambelli, F.; Masiero, S.; Calabritto, A.; Costantini, E.; Forlani, S.; Marsoni, M.; Briani, F.; Vannini, C.; Pesaresi, P.
10.1101/2022.07.19.500576 — plant biology — Posted on 2022-07-19
1600 Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications.
Roura, A.-J.; Szadkowska, P.; Poleszak, K.; Dabrowski, M. J.; Ellert-Miklaszewska, A.; Wojnicki, K.; Ciechomska, I. A.; Stepniak, K.; Kaminska, B.; Wojtas, B.
10.1101/2022.07.18.500476 — cancer biology — Posted on 2022-07-19
1603 A comprehensive prediction of transcript isoforms in 19 chicken tissues by Oxford Nanopore long-read sequencing
Guan, D.; Halstead, M. M.; Islas-Trejo, A. D.; Goszczynski, D. E.; Cheng, H. H.; Ross, P.; Zhou, H.
10.1101/2022.07.18.500519 — genomics — Posted on 2022-07-19
1605 Reduced parasite burden in feral honeybee colonies
Kohl, P. L.; D'Alvise, P.; Rutschmann, B.; Roth, S.; Remter, F.; Steffan-Dewenter, I.; Hasselmann, M.
10.1101/2022.07.18.500457 — ecology — Posted on 2022-07-19
1611 X chromosome factor Kdm6a enhances memory independent of its demethylase function in the aging XY male brain
Shaw, C. K.; Abdulai-Saiku, S.; Marino, F.; Wang, D.; Davis, E. J.; Panning, B.; Dubal, D. B.
10.1101/2022.07.18.500498 — neuroscience — Posted on 2022-07-19
1612 ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice
Schuster, K. H.; Zalon, A. J.; DiFranco, D. M.; Putka, A. F.; Stec, N.; Jarrah, S.; Naeem, A.; Haque, Z.; Zhang, H.; Guan, Y.; McLoughlin, H. S.
10.1101/2022.07.18.500473 — neuroscience — Posted on 2022-07-19
1616 Genomic mapping of the modifiers of Teosinte crossing barrier 1 (Tcb1)
Maharjan, N.; Khaipho-Burch, M. B.; Awale, P.; Gyawali, A.; Shrestha, V.; Wu, Y.; Auger, D. L.
10.1101/2022.07.18.500501 — plant biology — Posted on 2022-07-19
1619 Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2.
Hall, J.; Hofmeister, E.; Ip, H.; Nashold, S.; Leon, A.; Malave, C.; Falendysz, E.; Rocke, T.; Carossino, M.; Balasuriya, U.; Knowles, S.
10.1101/2022.07.18.500430 — pathology — Posted on 2022-07-18
1620 Taxanes act as vascular disrupting agents and increase rate of metastasis when combined with anti-angiogenic therapy
Nandigama, R.; Kallius, M.; Hemmen, K.; Shaoli, D.; Pinnecker, J.; Ascheid, D.; Burkhard, V.; Ali, H.; Scheld, D.; Herterich, S.; Zernecke, A.; Penack, O.; Diller, S.; Camphausen, K.; Erguen, S.; Shankavaram, U.; Heinze, K.; Escorcia, F.; Henke, E.
10.1101/2022.07.18.500307 — cancer biology — Posted on 2022-07-19
1621 Pyruvate carboxylation identifies Glioblastoma Stem-like Cells opening new metabolic strategy to prevent tumor recurrence
Renoult, O.; Gratas, C.; Joalland, N.; Laurent--Blond, M.; Awada, H.; Bourgeois, M.; Oliver, L.; Chiavassa, S.; Croyal, M.; Paris, F.; Pecqueur, C.
10.1101/2022.07.18.500427 — cancer biology — Posted on 2022-07-19
1622 Enhanced cell viscosity as a marker of premature senescence induced by lamin A/C alterations
Jebane, C.; Varlet, A.-A.; Karnat, M.; Hernandez-Cedillo, L. M.; Lecchi, A.; Bedu, F.; Desgrouas, C.; Vigouroux, C.; Vantyghem, M.-C.; Viallat, A.; Rupprecht, J.-F.; Helfer, E.; Badens, C.
10.1101/2022.07.18.500411 — biophysics — Posted on 2022-07-19
1623 Dynamic live/apoptotic cell assay using phase-contrast imaging and deep learning
Korczak, Z.; Pineda, J.; Helgadottir, S.; Midtvedt, B.; Goksör, M.; Volpe, G.; Adiels, C. B.
10.1101/2022.07.18.500422 — biophysics — Posted on 2022-07-19
1624 GTPase-dependent cyclic flexibility transitions drive the two-component EEA1-Rab5 molecular motor
Singh, A.; Soler, J. A.; Lauer, J.; Grill, S. W.; Jahnel, M.; Zerial, M.; Thutupalli, S.
10.1101/2022.07.18.500463 — biophysics — Posted on 2022-07-19
1626 AFM-based force spectroscopy unravels the stepwise-formation of a DNA transposition complex driving multi-drug resistance dissemination
Fernandez, M.; Shkumatov, A. V.; Liu, Y.; Stulemeijer, C.; Derclaye, S.; Efremov, R. G.; Hallet, B.; Alsteens, D.
10.1101/2022.07.18.500257 — biophysics — Posted on 2022-07-19
1628 Complexes of tubulin oligomers and tau form an intervening network cross-bridging microtubules into bundles
Kohl, P.; Song, C.; Fletcher, B. J.; Best, R. L.; Tchounwou, C.; Arceo, X. G.; Chung, P. J.; Miller, H. P.; Wilson, L.; Choi, M. C.; Li, Y.; Feinstein, S. C.; Safinya, C. R.
10.1101/2022.07.18.500499 — biophysics — Posted on 2022-07-19
1630 A human RNA ligase that operates via auto- and RNA-AMPylation
Yuan, Y.; Stumpf, F. M.; Schlor, L. A.; Schmidt, O. P.; Huber, L. B.; Frese, M.; Scheffner, M.; Stengel, F.; Diederichs, K.; Marx, A.
10.1101/2022.07.18.500566 — biochemistry — Posted on 2022-07-19
1631 Spatial host-microbiome sequencing
Lötstedt, B.; Strazar, M.; Xavier, R. J.; Regev, A.; Vickovic, S.
10.1101/2022.07.18.500470 — genomics — Posted on 2022-07-19
1632 Rounding up the annual ryegrass genome: high-quality reference genome of Lolium rigidum
Paril, J.; Pandey, G.; Barnett, E.; Rane, R. V.; Court, L.; Walsh, T.; Fournier-Level, A.
10.1101/2022.07.18.499821 — genomics — Posted on 2022-07-19
1633 Topological screen identifies hundreds of Cp190 and CTCF dependent Drosophila chromatin insulator elements
Kahn, T. G.; Savitsky, M.; Kuong, C.; Jacquer, C.; Cavalli, G.; Chang, J.-M.; Schwartz, Y. B.
10.1101/2022.07.18.500462 — genomics — Posted on 2022-07-19
1634 A unique H2B acetylation signature marks active enhancers and predicts their target genes
Narita, T.; Higashijima, Y.; Kilic, S.; Liebner, T.; Walter, J.; Choudhary, C.
10.1101/2022.07.18.500459 — genomics — Posted on 2022-07-19
1635 Epstein-Barr virus nuclear antigen proteins deploy diverse mechanisms to bind the human genome
Haque, M. R.; Tushar, A. R.; Park, M.; Moon, C. I.; Rahman, M. S.; Samee, M. A. H.
10.1101/2022.07.18.500442 — genomics — Posted on 2022-07-19
1636 Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin
Natarajan, C.; Signore, A. V.; Bautista, N. M.; Hoffmann, F. G.; Tame, J. R.; Fago, A.; Storz, J. F.
10.1101/2022.07.18.500494 — evolutionary biology — Posted on 2022-07-19
1638 Canonical Wnt Signaling Maintains Human Mesenchymal Progenitor Cell Multipotency During Adipose Tissue Development
Loureiro, Z. Y.; Joyce, S.; Solivan-Rivera, J.; Desai, A.; Skritakis, P.; Yang, Q.; DeSouza, T.; Nguyen, T.; MacDougald, O. A.; Corvera, S.
10.1101/2022.07.18.500487 — developmental biology — Posted on 2022-07-18
1639 Fibronectin deficiency in newborn mice leads to cyst formation in the kidney
Hermann, K.; Seibold, S.; Skoczynski, K.; Buchholz, B.; Tamm, E. R.; Herrnberger-Eimer, L.
10.1101/2022.07.18.500556 — developmental biology — Posted on 2022-07-19
1642 Impaired Function in Diabetic Patient iPSCs-derived Blood Vessel Organoids Stem from a Subpopulation of Vascular Cells
Naderi-Meshkin, H.; Eleftheriadou, M.; Carney, G.; Cornelius, V. A.; Nelson, C.-A.; Kelaini, S.; Yacoub, A.; Donaghy, C.; Dunne, P. D.; Amirkhah, R.; Zampetaki, A.; Zeng, L.; Stitt, A. W.; Grieve, D. J.; Margariti, A.
10.1101/2022.07.18.500478 — cell biology — Posted on 2022-07-18
1643 SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX
Wagner, A. R.; Weindel, C. G.; West, K. O.; Scott, H. M.; Watson, R. O.; Patrick, K. L.
10.1101/2022.07.18.500495 — molecular biology — Posted on 2022-07-18
1644 Corruption of DNA End-Joining in Mammalian Chromosomes by Progerin Expression
Joudeh, L. A.; DiCintio, A. A.; Ries, M. R.; Gasperson, A. S.; Griffen, K. E.; Robbins, V. P.; Bonner, M.; Nolan, S.; Black, E.; Waldman, A. S.
10.1101/2022.07.18.500488 — molecular biology — Posted on 2022-07-19
1646 Intrinsic BMP inhibitor Gremlin regulates lung alveolar progenitor cell proliferation and differentiation
Yanagihara, T.; Zhou, Q.; Tsubouchi, K.; Revill, S.; Ayoub, A.; Chong, S. G.; Dvorkin-Gheva, A.; Ask, K.; Shi, W.; Kolb, M. R.
10.1101/2022.07.18.500545 — molecular biology — Posted on 2022-07-19
1647 Transcriptional profiling of hepatocytes infected with the replicative form of the malaria parasite Plasmodium cynomolgi
Mitchell, G.; Roma, G.; Voorberg-van der Wel, A.; Beibel, M.; Zeeman, A.-M.; Schuierer, S.; Torres, L.; Flannery, E. L.; Kocken, C. H. M.; Mikolajczak, S. A.; Diagana, T. T.
10.1101/2022.07.18.500418 — microbiology — Posted on 2022-07-18
1648 Erythrocyte signalling is critical for Plasmodium falciparum invasion
Yong, J. J. M.; Gao, X.; Prakash, P.; Lai, S. K.; Chen, M. W.; Neo, J. J. L.; Lescar, J.; Li, H. Y.; Preiser, P. R.
10.1101/2022.07.18.500419 — microbiology — Posted on 2022-07-18
1649 Variable impact of geochemical gradients on the functional potential of bacteria, archaea, and phages from the permanently stratified Lac Pavin
Jaffe, A. L.; Bardot, C.; Le Jeune, A.-H.; Liu, J.; Colombet, J.; Perriere, F.; Billard, H.; Castelle, C. J.; Lehours, A.-C.; Banfield, J.
10.1101/2022.07.18.500538 — microbiology — Posted on 2022-07-19
1652 Culturomics of Andropogon gerardii rhizobiome revealed nitrogen transforming capabilities of stress-tolerant Pseudomonas under drought conditions
Sarkar, S.; Kamke, A.; Ward, K.; Hartung, E.; Ran, Q.; Feehan, B.; Galliart, M.; Jumpponen, A. M.; Johnson, L.; Lee, S. T. M.
10.1101/2022.07.18.500515 — microbiology — Posted on 2022-07-19
1653 A virus-induced circular RNA maintains latent infection of Kaposi sarcoma herpesvirus
Tagawa, T.; Oh, D.; Dremel, S.; Mahesh, G.; Koparde, V. N.; Duncan, G.; Andresson, T.; Ziegelbauer, J. M.
10.1101/2022.07.18.500467 — microbiology — Posted on 2022-07-19
1655 Dynamic acylome reveals metabolite driven modifications in Syntrophomonas wolfei
Fu, J. Y.; Muroski, J. M.; Arbing, M. A.; Salguero, J. A.; Wofford, N. Q.; McInerney, M. J.; Gunsalus, R. P.; Loo, J. A.; Loo, R. R. O.
10.1101/2022.07.18.500474 — microbiology — Posted on 2022-07-19
1656 Varidnaviruses in the human gut: a major expansion of the order Vinavirales
Yutin, N.; Rayko, M.; Antipov, D.; Mutz, P.; Wolf, Y. I.; Krupovic, M.; Koonin, E. V.
10.1101/2022.07.18.500477 — microbiology — Posted on 2022-07-19
1659 Biphasic response of CD8 T cell to asparagine restriction maximizes its metabolic fitness and antitumoral functionality
Gnanaprakasam, J. R.; Liu, L.; Chen, X.; Kang, S.; Wang, T.; Cassel, T. A.; Adams, C. M.; Higashi, R. M.; Scott, D. A.; Xin, G.; Yang, J.; Lane, A. N.; Fan, T. W.; Zhang, J.; Wang, R.
10.1101/2022.07.18.500458 — immunology — Posted on 2022-07-18
1661 Thalamus sends information about arousal but not valence to the amygdala
Leppla, C. A.; Keyes, L.; Glober, G.; Matthews, G. A.; Batra, K.; Jay, M.; Feng, Y.; Chen, H. S.; Mills, F.; Delahanty, J.; Olsen, J.; Nieh, E. H.; Namburi, P.; Wildes, C.; Wichmann, R.; Beyelar, A.; Kimchi, E. Y.; Tye, K. M.
10.1101/2022.07.18.500471 — neuroscience — Posted on 2022-07-18
1662 Proteome coverage after simultaneous proteo-metabolome liquid-liquid extraction
van Pijkeren, A.; Egger, A.-S.; Hotze, M.; Zimmermann, E.; Grander, J.; Koeberle, A.; Bischoff, R.; Gollowitzer, A.; Thedieck, K.; Kwiatkowski, M.
10.1101/2022.07.18.500507 — systems biology — Posted on 2022-07-18
1665 Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart
Read, D. F.; Booth, G. T.; Daza, R. M.; Jackson, D. L.; Gladden, R. G.; Srivatsan, S. R.; Ewing, B.; Franks, J. M.; Spurrell, C. H.; Gomes, A. R.; O'Day, D.; Gogate, A. A.; Martin, B. K.; Starita, L. M.; Lin, Y.; Shendure, J.; Lin, S.; Trapnell, C.
10.1101/2022.07.12.496461 — genomics — Posted on 2022-07-19
1666 An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii
Lopez, J. M.; Tengganu, I. F.; Liu, J.; Murray, J. M.; Arias Padilla, L. F.; Zhang, Y.; Brown, P. T.; Florens, L.; Hu, K.
10.1101/2022.05.20.492694 — cell biology — Posted on 2022-07-19
1669 High-throughput platform of reconstituted depolarization-induced Ca2+ release for skeletal muscle disease mutation validation and drug discovery
Murayama, T.; Kurebayashi, N.; Numaga-Tomita, T.; Kobayashi, T.; Okazaki, S.; Yamashiro, K.; Nakada, T.; Mori, S.; Ishida, R.; Kagechika, H.; Yamada, M.; Sakurai, T.
10.1101/2022.06.29.498090 — physiology — Posted on 2022-07-18
1672 Dynamic Ins2 gene activity defines β-cell maturity states
Chu, C. M. J.; Modi, H.; Skovso, S.; Ellis, C.; Krentz, N. A. J.; Zhao, Y. B.; Cen, H.; Noursadeghi, N.; Panzhinskiy, E.; Hu, X.; Dionne, D. A.; Xia, Y. h.; Xuan, S.; Huising, M. O.; Kieffer, T. J.; Lynn, F. C.; Johnson, J.
10.1101/702589 — cell biology — Posted on 2022-07-18
1675 At-home blood collection and stabilization in high temperature climates using homeRNA
Brown, L. G.; Haack, A. J.; Kennedy, D. S.; Adams, K. N.; Stolarczuk, J. E.; Takezawa, M. G.; Berthier, E.; Thongpang, S.; Lim, F. Y.; Chaussabel, D.; Garand, M.; Theberge, A. B.
10.1101/2022.03.23.485526 — bioengineering — Posted on 2022-07-18
1677 What the book of Lambda doesnt tell us about temperate phages and lysogeny in the real world
Berryhill, B. A.; Garcia, R.; McCall, I. C.; Chaudhry, W.; Petite, M.-A.; Levin, B. R.
10.1101/2022.05.11.491505 — evolutionary biology — Posted on 2022-07-18
1680 Human CD4/CD8 double positive T cells are both predictive and sufficient to mediate GVHD pathology
Hess, N. J.; Turicek, D. P.; Riendeau, J.; McIlwain, S. J.; Contreras Guzman, E.; Nadiminti, K.; Hudson, A.; Callander, N. S.; Skala, M. C.; Gumperz, J. E.; Hematti, P.; Capitini, C. M.
10.1101/2022.01.11.475845 — immunology — Posted on 2022-07-18
1681 Transcriptome responses of virus-transmitting aphid vectors are shaped by the host plant and the virus mode of transmission
Chesnais, Q.; Golyaev, V.; Velt, A.; Rustenholz, C.; Verdier, M.; Brault, V.; Pooggin, M. M.; Drucker, M.
10.1101/2022.07.18.500449 — plant biology — Posted on 2022-07-18
1682 Drivers of genomic landscapes of differentiation across Populus divergence gradient
Shang, H.; Rendon-Anaya, M.; Paun, O.; Field, D. L.; Hess, J.; Vogl, C.; Liu, J.; Ingvarsson, P. K.; Lexer, C.; Leroy, T.
10.1101/2021.08.26.457771 — evolutionary biology — Posted on 2022-07-18
1684 Primate simplexviruses differ in tropism for macaque cells
Hofmann-Winkler, H.; Siregar, A. R.; Rodriguez Polo, I.; Esiyok, N.; Gaertner, S.; Behr, R.; Pöhlmann, S.; Winkler, M.
10.1101/2022.07.18.500402 — microbiology — Posted on 2022-07-18
1686 Cellular and molecular phenotypes of C9orf72 ALS/FTD patient derived iPSC-microglia mono-cultures
Lorenzini, I.; Alsop, E.; Levy, J.; Gittings, L. M.; Lall, D.; Rabichow, B. E.; Moore, S.; Pevey, R.; Bustos, L.; Burciu, C.; Bhatia, D.; Singer, M.; Saul, J.; McQuade, A.; Tzioras, M.; Mota, T. A.; Logemann, A.; Rose, J.; Almeida, S.; Gao, F.-B.; Marks, M.; Donnelly, C. J.; Bowser, R.; Spires-Jones, T. L.; Blurton-Jones, M.; Gendron, T. F.; Baloh, R. H.; Van Keuren-Jensen, K.; Sattler, R.
10.1101/2020.09.03.277459 — neuroscience — Posted on 2022-07-18
1688 An automated workflow for multi-omics screening of microbial model organisms
Donati, S.; Mattanovich, M.; Hjort, P.; Jacobsen, S. A. B.; Blomquist, S. D.; Mangaard, D.; Gurdo, N.; Pastor, F. P.; Maury, J.; Hanke, R.; Herrgard, M.; Wulff, T.; Jakociunas, T.; Nielsen, L. K.; McCloskey, D.
10.1101/2022.07.18.500181 — systems biology — Posted on 2022-07-18
1689 Genetic analysis of global faba bean germplasm maps agronomic traits and identifies strong selection signatures for geographical origin
Skovbjerg, C. K. K.; Angra, D.; Robertson-Shersby-Harvie, T.; Kreplak, J.; Ecke, W.; Windhorst, A.; Nielsen, L. K.; Schiemann, A.; Knudsen, J.; Gutierrez, N.; Tagkouli, V.; Fechete, L. I.; Janss, L.; Stougaard, J.; Warsame, A.; Alves, S.; Khazaei, H.; Link, W.; Torres, A. M.; O'Sullivan, D. M.; Andersen, S. U.
10.1101/2022.07.18.500421 — genetics — Posted on 2022-07-18
1691 Differential effect of climate on structural and biochemical plant traits
Thakur, D.; Hadincov, V.; Schnablova, R.; Synkova, H.; Haisel, D.; Wilhelmova, N.; Dostalek, T.; Munzbergova, Z.
10.1101/2022.07.18.500466 — ecology — Posted on 2022-07-18
1692 Unveiling hidden eukaryotes: diversity of Endomyxa (Rhizaria) in coastal marine habitats
Berney, C.; Ciaghi, S.; Romac, S.; Mahe, F.; de Vargas, C.; Jaillon, O.; Kirchmair, M.; Bass, D.; Neuhauser, S.
10.1101/2022.07.18.500052 — microbiology — Posted on 2022-07-18
1693 Identification of a Papain-Like Protease Inhibitor with Potential for Repurposing in Combination with an Mpro Protease Inhibitor for Treatment of SARS-CoV-2
Campagna, J.; Jagodzinska, B.; Alvarez, P.; Yeun, C.; Spilman, P.; Enquist, K. M.; Cohn, W.; Fajtov, P.; O'Donoghue, A. J.; Arumugaswami, V.; Li, M. M. H.; Damoiseaux, R.; John, V.
10.1101/2022.07.18.500363 — microbiology — Posted on 2022-07-18
1694 Effector Th1 cells alter the transcriptional output of IL-6 in acute resolving inflammation
Millrine, D.; Cardus Figueras, A.; Uceda Fernandez, J.; Andrews, R.; Szomolay, B.; Cossins, B. C.; Rice, C.; Li, J.; Tyrrell, V.; mcLeod, L.; Holmans, P.; O'Donnell, V.; Taylor, P.; Turner, S. J.; Jenkins, B. J.; Jones, G. W.; Topley, N.; Williams, N. M.; Jones, S. A.
10.1101/2022.07.18.499157 — immunology — Posted on 2022-07-18
1698 Fine-mapping and comparative genomic analysis reveal the gene composition at the S and Z self-incompatibility loci in grasses
Rohner, M.; Manzanares, C.; Yates, S.; Thorogood, D.; Copetti, D.; Lübberstedt, T.; Asp, T.; Studer, B.
10.1101/2022.07.18.499170 — plant biology — Posted on 2022-07-18
1699 An autoregulatory feedback loop converging on H2A ubiquitination drives synovial sarcoma
Benabdallah, N. S.; Dalal, V.; Sotiriou, A.; Scott, R. W.; Kommoss, F. K.; Pejkovska, A.; Gaspar, L.; Wagner, L.; Sanchez-Rivera, F. J.; Ta, M.; Thornton, S.; Nielsen, T. O.; Underhill, T. M.; Banito, A.
10.1101/2022.07.18.499263 — cancer biology — Posted on 2022-07-18
1702 Porous microneedle patch with sustained exosomes delivery repairs severe spinal cord injury
Fang, A.; Wang, Y.; Guan, N.; Lin, L.; Guo, B.; Cai, W.; Chen, X.; Ye, J.; Abdelrahman, Z.; Jin, S.; Yu, B.; Gu, X.; Wang, X.
10.1101/2022.07.18.500400 — bioengineering — Posted on 2022-07-18
1703 Spatially resolved host-bacteria-fungi interactomes via spatial metatranscriptomics
Saarenpää, S.; Shalev, O.; Ashkenazy, H.; de Oliveira-Carlos, V.; Lundberg, D. S.; Weigel, D.; Giacomello, S.
10.1101/2022.07.18.496977 — genomics — Posted on 2022-07-18
1709 The energetics of rapid cellular mechanotransduction
Young, M. N.; Sindoni, M. J.; Lewis, A. H.; Zauscher, S.; Grandl, J.
10.1101/2022.07.17.500355 — neuroscience — Posted on 2022-07-18
1710 A transformer model for predicting cognitive impairment from sleep
Song, T.-A.; Malekzadeh, M.; Saxena, R.; Purcell, S. M.; Dutta, J.
10.1101/2022.07.17.500351 — neuroscience — Posted on 2022-07-18
1723 Spatial transcriptomics of FFPE pancreatic intraepithelial neoplasias reveals cellular and molecular alterations of progression to pancreatic ductal carcinoma
Bell, A. T. F.; Mitchell, J. T.; Kiemen, A. L.; Fujikura, K.; Fedor, H.; Gambichler, B.; Deshpande, A.; Wu, P.-H.; Sidiropoulos, D. N.; Erbe, R.; Stern, J.; Chan, R.; Williams, S.; Chell, J. M.; Zimmerman, J. W.; Wirtz, D.; Jaffee, E. M.; Wood, L. D.; Fertig, E. J.; Kagohara, L. T.
10.1101/2022.07.16.500312 — cancer biology — Posted on 2022-07-18
1724 Geometry-driven migration efficiency of minimal cell clusters
Vercruysse, E.; Brückner, D. B.; Gomez-Gonzalez, M.; Luciano, M.; Kalukula, Y.; Rossetti, L.; Trepat, X.; Hannezo, E.; GABRIELE, S.
10.1101/2022.07.17.500364 — biophysics — Posted on 2022-07-18
1742 Dynamic cortical and tractography atlases of proactive and reactive alpha and high-gamma activities
Ono, H.; Sonoda, M.; Sakakura, K.; Kitazawa, Y.; Mitsuhashi, T.; Firestone, E.; Luat, A. F.; Marupudi, N. I.; Sood, S.; ASANO, E.
10.1101/2022.07.16.500323 — neuroscience — Posted on 2022-07-18
1744 Mixed selectivity coding of content-temporal detail by dorsomedial posterior parietal neurons
Wang, L.; Zhou, X.; Yang, J.; Zeng, F.; Zuo, S.; Kusunoki, M.; Wang, H.; Zhou, Y.-d.; Chen, A.; Kwok, S. C.
10.1101/2022.07.16.500237 — neuroscience — Posted on 2022-07-18
1748 Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer
Alshehri, S.; Pavlovic, T.; Farsinejad, S.; Behboodi, P.; Quan, L.; Centeno, D.; Kung, D.; Rezler, M.; Lee, W.; Jasinski, P.; Dziabaszewska, E.; Nowak-Markwitz, E.; Kalyon, D.; Zaborowski, M.; Iwanicki, M.
10.1101/2022.01.30.478322 — cancer biology — Posted on 2022-07-18
1749 Rarity: Discovering rare cell populations from single-cell imaging data
Marten, K.; Bortolomeazzi, M.; Montorsi, L.; Spencer, J.; Ciccarelli, F. D.; Yau, C.
10.1101/2022.07.15.500256 — bioinformatics — Posted on 2022-07-18
1751 Illuminating the Druggable Genome through Patent Bioactivity Data
Leach, A. R.; Magarinos, M. P.; Gaulton, A.; Felix, E.; Kiziloren, T.; Arcila, R.; Oprea, T. I.
10.1101/2022.07.15.500187 — bioinformatics — Posted on 2022-07-18
1752 A community driven GWAS summary statistics standard
Hayhurst, J.; Buniello, A.; Harris, L.; Mosaku, A.; Chang, C.; Gignoux, C. R.; Hatzikotoulas, K.; Karim, M. A.; Lambert, S. A.; Lyon, M.; McMahon, A.; Okada, Y.; Pirastu, N.; Rayner, N. W.; Schwartzentruber, J.; Vaughan, R.; Verma, S.; Wilder, S. P.; Cunningham, F.; Hindorff, L.; Wiley, K.; Parkinson, H.; Barroso, I.
10.1101/2022.07.15.500230 — bioinformatics — Posted on 2022-07-18
1755 Trait-specific patterns of community ecospace occupancy in an insular mammal radiation
Nations, J. A.; Kohli, B. A.; Handika, H.; Achmadi, A. S.; Polito, M. J.; Rowe, K. C.; Esselstyn, J. A.
10.1101/2022.07.15.500274 — ecology — Posted on 2022-07-18
1757 Dietary non-starch polysaccharides impair immunity to enteric nematode infection
Valente, A. H.; Jensen, K. M. R.; Myhill, L. J.; Zhu, L.; Mentzel, C. M. J.; Krych, L.; Simonsen, H. T.; Castro Mejia, J. L.; Gobbi, A.; Bach Knudsen, K. E.; Nielsen, D. S.; Thamsborg, S. M.; Williams, A. R.
10.1101/2022.07.15.500167 — immunology — Posted on 2022-07-18
1759 Hippocampal Place-like Signal in Latent Social Space
Schafer, M.; Kamilar-Britt, P.; Sahani, V.; Bachi, K.; Schiller, D.
10.1101/2022.07.15.499827 — neuroscience — Posted on 2022-07-18
1760 In vitro and in silico analysis proving DPP4 inhibition and diabetes associated gene network modulation by a polyherbal formulation - Nisakathakadi Kashaya.
Thottappillil, A.; Sahoo, S.; Chakraborty, A.; Kouser, S.; Ravi, V.; Garawadmath, S.; Banvi, P. G.; Kukkupuni, S. K.; Mohan, S.; Chethala N, V.
10.1101/2022.07.15.500175 — systems biology — Posted on 2022-07-18
1761 Study of the anti-inflammatory and anti-apoptosis effect of the traditional Mongolian Hohgardi-9 in acute lung injury
Qimuge, A.; Bilige, B.; Qimuge, W.; Siqin, S.; Hang, H.; Temuqile, T.; Chen, S.; Baigued, H.; Wang, C.; Baiyin, T.; Yang, D.
10.1101/2022.07.14.500152 — pharmacology and toxicology — Posted on 2022-07-18
1763 Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma.
DeMartino, J.; Meister, M. T.; Visser, L.; Brok, M.; Groot Koerkamp, M. J. A.; Hiemcke-Jiwa, L. S.; de Souza, T.; Merks, J.; Holstege, F. C.; Margaritis, T.; Drost, J.
10.1101/2022.07.15.497944 — cancer biology — Posted on 2022-07-18
1764 Influence of genetic ancestry on breast stromal cells provides biologic basis for increased incidence of metaplastic breast cancer in women of African descent
Kumar, B.; Batic, K.; Bhat-Nakshatri, P.; Granatir, M. M.; Addison, R. J.; Szymanski, M.; Baldridge, L. A.; Temm, C. J.; Sandusky, G.; Althouse, S. K.; Storniolo, A. M.; Nakshatri, H.
10.1101/2022.07.14.500115 — cancer biology — Posted on 2022-07-18
1769 Interpreting ICT: from Blood Flow to Vascular Network
Fang, Q.; Jafari, C. Z.; Engelmann, S.; Tomar, A.; Dunn, A.
10.1101/2022.07.15.500238 — bioengineering — Posted on 2022-07-18
1770 Exploring the emergence of morphological asymmetries around the brain's Sylvian fissure: a longitudinal study of shape variability in preterm infants.
de Vareilles, H.; Riviere, D.; Pascucci, M.; Sun, Z. Y.; Fischer, C.; Leroy, F.; Tataranno, M.-L.; Benders, M.; Dubois, J.; Mangin, J.-F.
10.1101/2022.07.15.500199 — neuroscience — Posted on 2022-07-18
1771 Maximum likelihood pandemic-scale phylogenetics
De Maio, N.; Kalaghatgi, P.; Turakhia, Y.; Corbett-Detig, R.; Minh, B. Q.; Goldman, N.
10.1101/2022.03.22.485312 — bioinformatics — Posted on 2022-07-18
1772 Frem1 activity regulated by Sonic Hedgehog signaling in the cranial neural crest mesenchyme guides midfacial morphogenesis
McLaughlin, M. T.; Sun, M. R.; Beames, T. G.; Steward, A. C.; Theisen, J. W.; Chung, H. M.; Everson, J. L.; Moskowitz, I. P.; Sheets, M. D.; Lipinski, R. J.
10.1101/2022.07.16.500318 — developmental biology — Posted on 2022-07-18
1773 Reciprocal regulation between cell mechanics and ZO-1 guides tight junction assembly and epithelial morphogenesis
Haas, A. J.; Zihni, C.; Krug, S. M.; Maraspini, R.; Otani, T.; Furuse, M.; Honigmann, A.; Balda, M.; Matter, K.
10.1101/2022.07.17.500023 — cell biology — Posted on 2022-07-18
1776 Plap-1/Aspn lineage tracing and single-cell transcriptomics reveals cellular dynamics in the periodontal ligament
Iwayama, T.; Iwashita, M.; Miyashita, K.; Sakashita, H.; Matsumoto, S.; Tomita, K.; Bhongsatiern, P.; Kitayama, T.; Ikegami, K.; Shimbo, T.; Tamai, K.; Murayama, M. A.; Ogawa, S.; Iwakura, Y.; Yamada, S.; Olson, L.; Takedachi, M.; Murakami, S.
10.1101/2022.07.16.500314 — developmental biology — Posted on 2022-07-18
1777 Osteocytes regulate organismal senescence of bone and bone marrow
Ding, P.; Gao, C.; Gao, Y.; Liu, D.; Li, H.; Xu, J.; Chen, X.; Huang, Y.; Zhang, C.; Zheng, M. H.; Gao, J.
10.1101/2022.07.17.500353 — cell biology — Posted on 2022-07-18
1778 SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine
Li, K.; Guzman, L. M.; Whitehead, L.; Leong, E.; Kueh, A. J.; Alexander, W. S.; Kershaw, N. J.; Babon, J. J.; Doggett, K.; Nicholson, S. E.
10.1101/2022.07.17.500381 — cell biology — Posted on 2022-07-18
1780 Melanoma cells appropriate pericyte:endothelial cell crosstalk during perivascular invasion in the brain
Zhang, Y.; Riedstra, C. P.; Wang, S.; Patel, S.; Bald, T.; Kumar, P.; Rohani, A.; Kashatus, D. F.; Moschos, S. J.; Dudley, A. C.
10.1101/2022.07.15.500231 — cancer biology — Posted on 2022-07-18
1782 Control of protein activity by photoinduced spin polarized charge reorganization
Ghosh, S.; Ghosh, K. B.; Levy, D.; Scheerer, D.; Riven, I.; Shin, J.; Gray, H.; Naaman, R.; Haran, G.
10.1101/2021.10.12.464058 — biophysics — Posted on 2022-07-18
1783 A highly contiguous, scaffold-level nuclear genome assembly for the Fever tree (Cinchona pubescens Vahl) as a novel resource for research in the Rubiaceae
Canales, N. A.; Perez Escobar, O. A.; Powell, R.; Topel, M.; Kidner, C.; Nesbitt, M.; Maldonado, C.; Barnes, C.; Ronsted, N.; Przelomska, N. A. S.; Leitch, I.; Antonelli, A.
10.1101/2022.04.25.489452 — bioinformatics — Posted on 2022-07-18
1786 COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis
Sinha, S.; Castillo, V.; Espinoza, C. R.; Tindle, C.; Fonseca, A. G.; Dan, J. M.; Katkar, G. D.; Das, S.; Sahoo, D.; Ghosh, P.
10.1101/2021.11.28.470269 — immunology — Posted on 2022-07-18
1788 The Arabidopsis SAC9 Enzyme is enriched in a cortical population of early endosomes and restricts PI(4,5)P2 at the Plasma Membrane
Lebecq, A.; Doumane, M.; Fangain, A.; Bayle, V.; Leong, J. X.; Rozier, F.; Marques-Bueno, M. d. M.; Armengot, L.; Boisseau, R.; Simon, M. L. A.; Franz-Wachtel, M.; Macek, B.; Ustun, S.; Jaillais, Y.; Caillaud, M.-C.
10.1101/2021.09.10.459735 — plant biology — Posted on 2022-07-18
1790 Environmental morphing enables informed dispersal of the dandelion diaspore
Seale, M.; Zhdanov, O.; Soons, M. B.; Cummins, C.; Kroll, E.; Blatt, M. R.; Zare-Behtash, H.; Busse, A.; Mastropaolo, E.; Bullock, J. M.; Viola, I. M.; Nakayama, N.
10.1101/542696 — plant biology — Posted on 2022-07-18
1794 u-track 3D: measuring and interrogating dense particle dynamics in three dimensions.
Roudot, P.; Legant, W. R.; Zou, Q.; Dean, K. M.; Isogai, T.; Welf, E. S.; David, A. F.; Gerlich, D. W.; Fiolka, R. P.; Betzig, E.; Danuser, G.
10.1101/2020.11.30.404814 — cell biology — Posted on 2022-07-18
1796 Cerebellar acceleration of learning in an evidence-accumulation task
Oostland, M.; Kislin, M.; Chen, Y.; Chen, T.; Venditto, S. J.; Deverett, B.; Wang, S. S.- H.
10.1101/2021.12.23.474034 — neuroscience — Posted on 2022-07-18
1797 Individual neurophysiological signatures of spontaneous rhythm processing
Criscuolo, A.; Schwartze, M.; Henry, M. J.; Obermeier, C.; Kotz, S. A.
10.1101/2022.03.14.484286 — neuroscience — Posted on 2022-07-18
1798 Genomic characterization of viruses associated with the parasitoid Anagyrus vladimiri (Hymenoptera: Encyrtidae)
Izraeli, Y.; Lepetit, D.; Atias, S.; Mozes-Daube, N.; Wodowsky, G.; Lachman, O.; Luria, N.; Steinberg, S.; Varaldi, J.; Zchori-Fein, E.; Chiel, E.
10.1101/2022.07.15.500286 — microbiology — Posted on 2022-07-18
1799 A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts
Gabelich, J.-A.; Grützke, J.; Kirscht, F.; Popp, O.; Matz, J. M.; Dittmar, G.; Rug, M.; Ingmundson, A.
10.1101/2022.07.14.500060 — microbiology — Posted on 2022-07-18
1807 Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled
Ronzano, R.; Skarlatou, S.; Barriga, B. K.; Bannatyne, B. A.; Bhumbra, G. S.; Foster, J. D.; Moore, J.; Lancelin, C.; Pocratsky, A.; Ozyurt, M. G.; Smith, C. C.; Todd, A. J.; Maxwell, D. J.; Murray, A. J.; Pfaff, S. L.; Brownstone, R. M.; Zampieri, N.; Beato, M.
10.1101/2021.02.10.430608 — neuroscience — Posted on 2022-07-18
1808 Interrelated effects of age and parenthood on whole-brain controllability: protective effects of parenthood in mothers
Jamalabadi, H.; Hahn, T.; Winter, N. R.; Nozari, E.; Ernsting, J.; Meinert, S.; Leehr, E.; Dohm, K.; Bauer, J.; Pfarr, J.-K.; Stein, F.; Thomas-Odenthal, F.; Brosch, K.; Mauritz, M.; Gruber, M.; Repple, J.; Kaufmann, T.; Krug, A.; Nenadic, I.; Kircher, T.; Dannlowski, U.; Derntl, B.
10.1101/2022.07.13.499891 — neuroscience — Posted on 2022-07-18
1811 Development of a bispecific Antibody Drug Conjugate targeting CD7 and CD33 to treat Acute Myeloid Leukaemia
Duckworth, A. D.; Eberlein, C.; Pollard, V.; Bethell, R.; Slupsky, J. R.; Schon, O.; Woolley, J. F.; Thorn, T.
10.1101/2022.07.17.500350 — cancer biology — Posted on 2022-07-18
1812 Targeting c-Jun is a potential therapy of luminal breast cancer bone metastasis
Han, Y.; Futakuchi, M.; Nakamichi, K.; Wakabayashi, Y.; Sakamoto, M.; Nakayama, J.; Semba, K.
10.1101/2022.07.17.500330 — cancer biology — Posted on 2022-07-18
1814 Three-dimensional humanized gingival tissue model to study oral microbiome
Adelfio, M.; Martin-Moldes, Z.; Erndt-Marino, J.; Tozzi, L.; Duncan, M. J.; Hasturk, H.; Kaplan, D. L.; Ghezzi, C. E.
10.1101/2022.07.17.500348 — bioengineering — Posted on 2022-07-18
1816 Validity Assessment of Michigan's Proposed qPCR Threshold Value for Rapid Water-Quality Monitoring of E. coli Contamination
McNair, J. N.; Lane, M. J.; Hart, J. J.; Porter, A.; Briggs, S.; Southwell, B.; Sivy, T.; Szlag, D. C.; Scull, B. T.; Pike, S.; Dreelin, E.; Vernier, C.; Carter, B.; Sharp, J.; Nowlin, P.; Rediske, R. R.
10.1101/2022.07.16.500300 — ecology — Posted on 2022-07-17
1820 Dissecting the genetic basis of the heterosis of Y900, an elite super-hybrid rice
sun, z.; Peng, J.; Lv, Q.; Ding, J.; Chen, S.; Duan, M.; He, Q.; wu, j.; Tian, Y.; Yu, D.; Tan, Y.; Sheng, X.; chen, j.; sun, x.; Liu, L.; Peng, R.; liu, h.; Zhou, T.; Xu, N.; Yuan, L.; wang, b.; yuan, d.
10.1101/2022.07.16.500322 — plant biology — Posted on 2022-07-17
1821 Wheat cells show positional responses to invasive Zymoseptoria tritici
Valente, F.; Mansfield, J.; Herring, D.; Romana, G.; Rodrigues, C.; Metz, J.; Craze, M.; Bowden, S.; Greenland, A.; Moger, J.; Haynes, K.; Richards, D. M.; Wallington, E.; Deeks, M. J.
10.1101/2022.07.15.499463 — plant biology — Posted on 2022-07-17
1823 Adipocyte differentiation of 3T3-L1 cells under TAF, TDF and INSTIs selective challenge: an in vitro model.
Perna, A.; Carleo, M. A.; Mascolo, S.; Guida, A.; Contieri, M.; Sellitto, C.; Hay, E.; De Blasiis, P.; Lucariello, A.; Guerra, G.; Baldi, A.; De Luca, A.; Maggi, P.; Esposito, V.
10.1101/2022.07.16.500298 — pharmacology and toxicology — Posted on 2022-07-17
1827 Cryptochrome Stabilization Ameliorates Chronic Pain
Wei, L.; Wu, Y.; Zirpel, F.; Flower, G.; Vierbergen, J. V.; Wieser, V.; Peirson, S.; Sleven, H.; Pokhilko, A.; Cader, Z. M.
10.1101/2022.07.15.499708 — neuroscience — Posted on 2022-07-17
1828 Translational regulation by RACK1 in astrocytes represses KIR4.1 expression and regulates neuronal activity
Oudart, M. -; Avila Gutierrez, K.; Moch, C.; Dossi, E.; Milior, G.; Boulay, A. C.; Gaudey, M.; Moulard, J.; Lombard, B.; Loew, D.; Bemelmans, A. P.; Rouach, N.; Cohen-Salmon, M.
10.1101/2022.07.16.500292 — neuroscience — Posted on 2022-07-17
1834 AGO2 silences mobile transposons in the nucleus of quiescent cells
Sala, L.; Chandrasekhar, S.; Cosby, R. L.; La Rocca, G.; Macfarlan, T.; Awasthi, P.; Chari, R.; Kruhlak, M.; Vidigal, J. A.
10.1101/2022.07.17.500356 — molecular biology — Posted on 2022-07-17
1838 Meta-analysis of fecal metagenomes reveals global viral signatures and its diagnostic potential for colorectal cancer and adenoma
Chen, F.; Li, S.; Guo, R.; Song, F.; Zhang, Y.; Wang, X.; Huo, X.; Lv, Q.; Ullah, H.; Wang, G.; Ma, Y.; Yan, Q.; Ma, X.
10.1101/2022.07.17.500372 — microbiology — Posted on 2022-07-17
1839 Structural basis for antibody-mediated neutralization of Lymphocytic choriomeningitis virus
Moon-Walker, A.; Zhang, Z.; Zyla, D. S.; Buck, T. K.; Li, H.; Diaz Avalos, R.; Schendel, S. L.; Hastie, K. M.; Crotty, S.; Saphire, E. O.
10.1101/2022.07.17.500368 — microbiology — Posted on 2022-07-17
1840 Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages
Bhiman, J. N.; Richardson, S. I.; Lambson, B. E.; Kgagudi, P.; Mzindle, N.; Kaldine, H.; Crowther, C.; Gray, G.; Bekker, L.-G.; Koen, A.; Fairlie, L.; Fouche, L.; Bhorat, Q.; Dheda, K.; Tameris, M.; Masilela, M. S. L.; Hoosain, Z.; Singh, N.; Hanley, S.; Archary, M.; Louw, C.; Grobbelaar, C.; Lalloo, U.; Joseph, N.; Kruger, G.; Shinde, V.; Bennett, C.; Glenn, G.; Madhi, S.; Moore, P. L.
10.1101/2022.07.14.500148 — immunology — Posted on 2022-07-17
1841 Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq
Sunshine, S.; Puschnik, A. S.; Replogle, J. M.; Laurie, M. T.; Liu, J.; Zha, B. S.; Nunez, J. K.; Byrum, J. R.; McMorrow, A. H.; Frieman, M. B.; Winkler, J.; Qiu, X.; Rosenberg, O. S.; Leonetti, M. D.; Ye, C. J.; Weissman, J. S.; DeRisi, J. L.; Hein, M. Y.
10.1101/2022.07.15.500120 — systems biology — Posted on 2022-07-17
1843 The sodium leak channel NALCN encodes the major background sodium ion conductance in mouse anterior pituitary cells
Belal, M.; Mucha, M.; Monteil, A.; Winyard, P. G.; Pawlak, R.; Walker, J. J.; Tabak, J.; Belle, M.
10.1101/2021.08.02.454810 — physiology — Posted on 2022-07-17
1844 Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform
Bojkova, D.; Reus, P.; Panosch, L.; Bechtel, M.; Rothenburger, T.; Kandler, J.; Pfeiffer, A.; Wagner, J. U.; Shumliakivska, M.; Dimmeler, S.; Olmer, R.; Martin, U.; Vondran, F.; Toptan, T.; Rothweiler, F.; Zehner, R.; Rabenau, H.; Osman, K. L.; Pullan, S. T.; Carroll, M. T.; Stack, R.; Ciesek, S.; Wass, M. N.; Michaelis, M.; Cinatl, J.
10.1101/2022.07.17.500346 — pharmacology and toxicology — Posted on 2022-07-17
1847 Drivers of genomic landscapes of differentiationacross Populus divergence gradient
Shang, H.; Rendon-Anaya, M.; Paun, O.; Field, D. L.; Hess, J.; Vogl, C.; Liu, J.; Ingvarsson, P. K.; Lexer, C.; Leroy, T.
10.1101/2021.08.26.457771 — evolutionary biology — Posted on 2022-07-17
1849 RASopathy Mutations Provide Functional Insight into the BRAF Cysteine-rich Domain and Demonstrate the Importance of Autoinhibition in BRAF Regulation
Spencer-Smith, R.; Terrell, E. M.; Insinna, C.; Agamasu, C.; Wagner, M. E.; Ritt, D. A.; Stauffer, J.; Stephen, A. G.; Morrison, D. K.
10.1101/2021.10.01.462773 — cell biology — Posted on 2022-07-17
1851 Measuring nonapoptotic caspase activity with a transgenic reporter in mice
Nicholls, P.; Pack, T.; Urs, N.; Kumar, S.; Zhou, Y.; Ichim, G.; Ginzel, J. D.; Turu, G.; Calabrese, E.; Roberts, W.; Fan, P.; Ostapchenko, V.; Guzman, M.; Beraldo, F.; Hatina, J.; Prado, V.; Prado, M.; Spasojevic, I.; Snyder, J.; Dzirasa, K.; Johnson, G. A.; Caron, M.
10.1101/196105 — neuroscience — Posted on 2022-07-17
1855 Three-dimensional structure of the kinetochore-fibers in human mitotic spindles
Kiewisz, R.; Fabig, G.; Conway, W.; Baum, D.; Needleman, D.; Muller-Reichert, T.
10.1101/2021.11.13.468347 — cell biology — Posted on 2022-07-17
1859 Citrus relatives exhibit natural variation in perception and response magnitude to microbial features
Trinh, J.; Li, T.; Franco, J. Y.; Toruno, T. Y.; Stevens, D. M.; Thapa, S. P.; Wong, J.; Pineda, R.; Avila de Dios, E.; Kahn, T. L.; Seymour, D. K.; Ramadugu, C.; Coaker, G. L.
10.1101/2022.07.15.500235 — plant biology — Posted on 2022-07-16
1860 Enhanced capillary pumping using open-channel capillary trees with integrated paper pads
Lee, J. J.; Berthier, J.; Dostie, A. M.; Khor, J. W.; Tokihiro, J. C.; Tu, W.-c.; Theberge, A. B.; Berthier, E.
10.1101/2022.07.15.500252 — bioengineering — Posted on 2022-07-16
1862 Molecular characteristics of diel rhythmic diversity reveal disconnection between different levels of organismal rhythmicity
Häfker, N. S.; Holcik, L.; Vadiwala, K.; Beets, I.; Stockinger, A. W.; Hammer, S.; Schoofs, L.; Raible, F.; Tessmar-Raible, K.
10.1101/2022.07.16.500291 — animal behavior and cognition — Posted on 2022-07-16
1864 Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition
Chann, A. S.; Charnley, M.; Newton, L. M.; Newbold, A.; Wiede, F.; Tiganis, T.; Humbert, P. O. O.; Johnstone, R. W.; Russell, S.
10.1101/2021.10.03.462949 — developmental biology — Posted on 2022-07-16
1865 A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome
Chitale, P.; Lemenze, A. D.; Fogarty, E. C.; Shah, A.; Grady, C. A.; Odom-Mabey, A. R.; Johnson, W. E.; Yang, J. H.; Eren, A. M.; Brosch, R.; Kumar, P.; Alland, D.
10.1101/2022.07.15.500236 — microbiology — Posted on 2022-07-16
1868 ACtivE: Assembly and CRISPR-targeted in vivo Editing for Yeast Genome Engineering Using Minimum Reagents and Time
MALCI, K.; Jonguitud-Borrego, N.; van der Straten, H.; Puodziunaite, U.; Johnston, E. J.; Rosser, S. J.; Rios Solis, L.
10.1101/2022.07.15.500277 — synthetic biology — Posted on 2022-07-16
1869 Gibberellins promote polar auxin transport to regulate stem cell fate decisions in cambium
Makila, R.; Wybouw, B.; Smetana, O.; Vainio, L.; Sole-Gil, A.; Lyu, M.; Ye, L.; Wang, X.; Siligato, R.; Jenness, M. K.; Murphy, A. S.; Mahonen, A. P.
10.1101/2022.07.15.500224 — plant biology — Posted on 2022-07-16
1871 Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy
Wienke, J.; Visser, L. L.; Kholosy, W. M.; Keller, K. M.; Barisa, M.; Munnings-Tomes, S.; Carlton, E.; Poon, E.; Rodriguez, A.; Bernardi, R.; Van den Ham, F.; Van Hooff, S. R.; Matser, Y. A. H.; Tas, M.; Langenberg, K. P. S.; Lijnzaad, P.; Strijker, J. G. M.; Sanchez-Bernabeu, A.; Cornel, A. M.; Holstege, F. C. P.; Gray, J. C.; Tytgat, L. A. M.; De Krijger, R.; Scheijde-Vermeulen, M. A.; Wijnen, M. H. W. A.; Dierselhuis, M. P.; Straathof, K.; Behjati, S.; Wu, W.; Heck, A. J. R.; Koster, J.; Nierkens, S.; Chesler, L.; Anderson, J.; Caron, H. N.; Margaritis, T.; Van Noesel, M. M.; Molenaar, J. J
10.1101/2022.07.15.499859 — cancer biology — Posted on 2022-07-16
1874 FMRP DIRECTLY INTERACTS WITH R-LOOP AND SHOWS COMPLEX INTERPLAY WITH THE DHX9 HELICASE
Chakraborty, A.; Dutta, A.; Dettori, L. G.; Gonzalez, L.; Xue, X.; Hehnly, H.; Sung, P.; Bah, A.; Feng, W.
10.1101/2021.04.21.440759 — biochemistry — Posted on 2022-07-16
1875 Urban birds' flight responses were unaffected by the COVID-19 shutdowns
Mikula, P.; Bulla, M.; Blumstein, D.; Benedetti, Y.; Floigl, K.; Jokimaki, J.; Kaisanlahti-Jokimaki, M.-L.; Marko, G.; Morelli, F.; Moller, A. P.; Siretckaia, A.; Szakony, S.; Weston, M.; Zeid, F. A.; Tryjanowski, P.; Albrecht, T.
10.1101/2022.07.15.500232 — animal behavior and cognition — Posted on 2022-07-16
1876 Establishment and Characterization of Novel Canine Organoids with Organ-Specific Physiological Similarity
Zdyrski, C.; Gabriel, V.; Ospina, O. E.; Wickham, H.; Sahoo, D. K.; Dao, K.; Aguilar Meza, L. S.; Bedos, L.; Honold, S.; Pineyro, P.; Mochel, J. P.; Allenspach, K.
10.1101/2022.07.15.500059 — genetics — Posted on 2022-07-16
1879 Allele-specific expression reveals multiple paths to highland adaptation in maize
Hu, H.; Crow, T. M.; Nojoomi, S.; Schulz, A. J.; Estevez-Palmas, J. M.; Hufford, M.; Flint-Garcia, S.; Sawers, R.; Rellan-Alvarez, R.; Ross-Ibarra, J.; Runcie, D. E.
10.1101/2022.07.15.500250 — evolutionary biology — Posted on 2022-07-16
1880 Actomyosin contractility in olfactory placode neurons opens the skin epithelium to form the nostril
Baraban, M.; Gordillo Pi, C.; Bonnet, I.; Gilles, J.-F.; Lejeune, C.; Cabrera, M.; Tep, F.; Breau, M.
10.1101/2022.07.15.500210 — developmental biology — Posted on 2022-07-16
1882 Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury
Papaioannou, S.; See, J.-X.; Jeong, M.; De La Torre, C.; Reiners-Koch, P.-S.; Sati, A.; Mogler, C.; Platten, M.; Cerwenka, A.; Stojanovic, A.
10.1101/2022.07.15.500206 — immunology — Posted on 2022-07-16
1884 Resting State Neural Networks at Complex Visual Hallucinations in Charles Bonnet Syndrome
Hanoglu, T.; Velioglu, H. A.; Salar, B. A.; Yıldız, S.; Bayraktaroglu, Z.; Yulug, B.; Hanoglu, L.
10.1101/2022.07.15.500190 — neuroscience — Posted on 2022-07-16
1885 Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex
Kim, M.-H.; Radaelli, C.; Thomsen, E. R.; Machen, D.; Chartrand, T.; Jorstad, N. L.; Mahoney, J. T.; Taormina, M. J.; Long, B.; Baker, K.; Campagnola, L.; Casper, T.; Clark, M.; Dee, N.; D'Orazi, F. D.; Gamlin, C.; Kalmbach, B.; Kebede, S.; Lee, B. R.; Ng, L.; Trinh, J.; Cobbs, C.; Gwinn, R. P.; Keene, C. D.; Ko, A. L.; Ojemann, J. G.; Silbergeld, D. L.; Sorensen, S. A.; Berg, J.; Smith, K.; Nicovich, P.; Jarsky, T.; Murphy, G.; Zeng, H.; Ting, J. T.; Levi, B. P.; Lein, E.
10.1101/2020.10.16.343343 — neuroscience — Posted on 2022-07-16
1890 Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand
Blount, B. A.; Lu, X.; Driessen, M. R. M.; Jovicevic, D.; Sanchez, M. I.; Ciurkot, K.; Zhao, Y.; Lauer, S.; McKiernan, R. M.; Gowers, G.-O. F.; Sweeney, F.; Fanfani, V.; Lobzaev, E.; Palacios-Flores, K.; Walker, R.; Hesketh, A.; Oliver, S. G.; Cai, Y.; Stracquadanio, G.; Mitchell, L. A.; Bader, J. S.; Boeke, J. D.; Ellis, T.
10.1101/2022.07.15.500197 — synthetic biology — Posted on 2022-07-16
1891 Programming the lifestyles of engineered bacteria for cancer therapy
Fu, S.; Zhang, R.; Gao, Y.; Xiong, J.; Li, Y.; Pu, L.; Xia, A.; Jin, F.
10.1101/2022.07.15.500166 — synthetic biology — Posted on 2022-07-16
1894 Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extracts
Schmidt, L.; Tueting, C.; Kyrilis, F. L.; Hamdi, F.; Semchonok, D. A.; Hause, G.; Meister, A.; Ihling, C.; Shah, P. N.; Stubbs, M. T.; Sinz, A.; Stuart, D. I.; Kastritis, P. L.
10.1101/2022.07.15.498668 — biochemistry — Posted on 2022-07-16
1897 Genome-Wide Association Study in a Rat Model of Temperament Identifies Multiple Loci for Exploratory Locomotion and Anxiety-Like Traits
Chitre, A. S.; Hebda-Bauer, E. K.; Blandino, P.; Bimschleger, H.; Nguyen, K.-M.; Maras, P.; Li, F.; Ozel, A. B.; Polesskaya, O.; Cheng, R.; Flagel, S. B.; Watson, S. J.; Li, J.; Akil, H.; Palmer, A. A.
10.1101/2022.07.12.499605 — genetics — Posted on 2022-07-16
1899 Engineering Agrobacterium tumefaciens adhesion to target cells.
Pierrat, X.; Pham, A.; Wong, J. P. H.; Al-Mayyah, Z.; Persat, A.
10.1101/2022.02.15.480547 — microbiology — Posted on 2022-07-16
1901 Joint coding of visual input and eye/head position in V1 of freely moving mice
Parker, P. R. L.; Abe, E. T. T.; Leonard, E. S. P.; Martins, D. M.; Niell, C. M.
10.1101/2022.02.01.478733 — neuroscience — Posted on 2022-07-16
1902 Sensorimotor feedback loops are selectively sensitive to reward
Codol, O.; Kashefi, M.; Forgaard, C. J.; Galea, J. M.; Pruszynski, J. A.; Gribble, P. L.
10.1101/2021.09.16.460659 — neuroscience — Posted on 2022-07-16
1903 An individualized causal framework for learning intercellular communicationnetworks that define microenvironments of individual tumors
Chen, X.; Chen, L.; Kurten, C. H. L.; Jabbari, F.; Vujanovic, L.; Ding, Y.; Lu, B.; Lu, K.; Kulkarni, A.; Tabib, T.; Lafyatis, R.; Cooper, G. F.; Ferris, R.; Lu, X.
10.1101/2021.11.11.467838 — cancer biology — Posted on 2022-07-16
1904 Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer
Alshehri, S.; Pavlovic, T.; Farsinejad, S.; Behboodi, P.; Quan, L.; Centeno, D.; Kung, D.; Rezler, M.; Lee, W.; Jasinski, P.; Dziabaszewska, E.; Nowak-Markwitz, E.; Kalyon, D.; Zaborowski, M.; Iwanicki, M.
10.1101/2022.01.30.478322 — cancer biology — Posted on 2022-07-16
1906 Mouse and cellular models of KPTN-related disorder implicate mTOR signalling in cognitive and progressive overgrowth phenotypes
Levitin, M. O.; Rawlins, L. E.; Sanchez-Andrade, G.; Arshad, O. A.; Collins, S. C.; Sawiak, S. J.; Iffland, P. H.; Andersson, M. H. L.; Bupp, C.; Cambridge, E. L.; Coomber, E. L.; Ellis, I.; Herkert, J. C.; Ironfield, H.; Jory, L.; Kretz, P. F.; Kant, S. G.; Neaverson, A.; Nibbeling, E.; Rowley, C.; Relton, E.; Sanderson, M.; Scott, E. M.; Stewart, H.; Shuen, A. Y.; Schreiber, J.; Tuck, L.; Tonks, J.; Terkelsen, T.; van Ravenswaaij-Arts, C.; Vasudevan, P.; Wenger, O.; Wright, M.; Day, A.; Hunter, A.; Patel, M.; Lelliott, C. J.; Crino, P. B.; Yalcin, B.; Crosby, A.; Baple, E. L.; Logan, D. W.;
10.1101/2022.07.15.500213 — genetics — Posted on 2022-07-16
1908 Does forest heterogeneity affect mean throughfall for regenerating secondary forests on Borneo?
Keller, N.; van Meerveld, I.; Philipson, C. D.; Asner, G. P.; Godoong, E.; Tangki, H.; Ghazoul, J.
10.1101/2022.07.14.500051 — ecology — Posted on 2022-07-16
1913 Sleep cycle-dependent vascular dynamics enhance perivascular cerebrospinal fluid flow and solute transport
Bojarskaite, L.; Bjornstad, D. M.; Vallet, A.; Binder, K. M. G.; Cunen, C.; Heuser, K.; Kuchta, M.; Mardal, K.-A.; Enger, R.
10.1101/2022.07.14.500017 — neuroscience — Posted on 2022-07-16
1914 Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions
Reemst, K.; Kracht, L.; Kotah, J. M.; Rahimian, R.; van Irsen, A. A. S.; Sotomayor, G. C.; Verboon, L. N.; Brouwer, N.; Simard, S.; Turecki, G.; Mechawar, N.; Kooistra, S. M.; Eggen, B. J. L.; Korosi, A.
10.1101/2022.07.13.499949 — neuroscience — Posted on 2022-07-16
1916 Single-cell transcriptomics of the Arabidopsis floral abscission zone
Taylor, I. W.; Patharkar, O. R.; Hsu, C.-W.; Baer, J.; Niederhuth, C. E.; Ohler, U.; Benfey, P. N.; Walker, J. C.
10.1101/2022.07.14.500021 — plant biology — Posted on 2022-07-16
1919 WNT4 executes estrogen regulation of cellular metabolism via intracellular activity at the mitochondria
Sottnik, J. L.; Shackleford, M. T.; Bahnassy, S.; Madak-Erdogan, Z.; Riggins, R. B.; Bitler, B. G.; Sikora, M. J.
10.1101/2022.07.15.499747 — cancer biology — Posted on 2022-07-16
1920 Rare Ribosomal RNA Sequences from Archaea Stabilize the Bacterial Ribosome
Nissley, A. J.; Penev, P. I.; Watson, Z. L.; Banfield, J.; Cate, J. H.
10.1101/2022.07.15.499945 — biophysics — Posted on 2022-07-16
1924 smalldisco, a pipeline for siRNA discovery and 3' tail identification
Vasconcellos Caldas, I.; Kelley, L. H.; Ahmed-Braimah, Y. H.; Maine, E. M.
10.1101/2022.07.15.500275 — molecular biology — Posted on 2022-07-16
1926 Transcriptomic and proteomic profiling of NaV1.8-expressing mouse nociceptors
Schmidt, M.; Sondermann, J. R.; Gomez-Varela, D.; Millet, Q.; Wood, J. N.; Zhao, J.
10.1101/2022.07.14.499815 — neuroscience — Posted on 2022-07-16
1932 ComBat Harmonization: Empirical Bayes versus Fully Bayes Approaches
Reynolds, M.; Chaudhary, T.; Torbati, M. E.; Tudorascu, D. L.; Batmanghelich, K.
10.1101/2022.07.13.499561 — neuroscience — Posted on 2022-07-16
1934 Individual-level Functional ConnectivityPredicts Cognitive Control Efficiency
Deck, B. L.; Kelkar, A.; Erickson, B. A.; Erani, F.; McConathey, E.; Sacchetti, D.; Faseyitan, O.; Hamilton, R.; Medaglia, J. D.
10.1101/2022.07.14.500048 — neuroscience — Posted on 2022-07-16
1935 Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas
Prosz, A.; Sahgal, P.; Morris, C. X.; Sztupinszki, Z.; Borcsok, J.; Diossy, M.; Tisza, V.; Spisak, S.; Rusz, O.; Csabai, I.; Huffman, B. M.; Singh, H.; Lazaro, J.-B.; Cecchini, M.; Cleary, J. M.; Szallasi, Z.; Sethi, N. S.
10.1101/2022.07.14.500118 — cancer biology — Posted on 2022-07-16
1936 Myeloid mechano-metabolic programming restricts anti-tumor immunity
Tharp, K.; Kersten, K.; Maller, O.; timblin, G.; Stashko, C.; Hayward, M.-K.; Berestjuk, I.; ten Hoeve-Scott, J.; Samad, B.; Combes, A.; Weaver, V.
10.1101/2022.07.14.499764 — cancer biology — Posted on 2022-07-16
1937 Inflammatory Signaling and Fibroblast-Cancer Cell Interactions Transfer from a Harmonized Human Single-cell RNA Sequencing Atlas of Pancreatic Ductal Adenocarcinoma to Organoid Co-Culture
Kinny-Koster, B.; Guinn, S.; Tandurella, J. A.; Mitchell, J. T.; Sidiropoulos, D. N.; Loth, M.; Lyman, M. R.; Pucsek, A. B.; Seppala, T. T.; Cherry, C.; Suri, R.; Zlomke, H.; He, J.; Wolfgang, C. L.; Yu, J.; Zheng, L.; Ryan, D. P.; Ting, D. T.; Kimmelman, A.; Gupta, A.; Danilova, L.; Elisseef, J.; Wood, L. D.; Stein-O'Brien, G.; Kagohara, L. T.; Burkhart, R. A.; Jaffee, E. M.; Fertig, E. J.; Zimmerman, J. W.
10.1101/2022.07.14.500096 — cancer biology — Posted on 2022-07-16
1938 AlphaPeptDeep: A modular deep learning framework to predict peptide properties for proteomics
Zeng, W.-F.; Zhou, X.-X.; Willems, S.; Ammar, C.; Wahle, M.; Bludau, I.; Voytik, E.; Strauss, M. T.; Mann, M.
10.1101/2022.07.14.499992 — bioinformatics — Posted on 2022-07-16
1939 RLSuite: An integrative R-loop bioinformatics framework
Miller, H. E.; Montemayor, D.; Levy, S. A.; Sharma, K.; Frost, B.; Bishop, A. J. R.
10.1101/2022.07.13.499820 — bioinformatics — Posted on 2022-07-16
1940 Metagenomic thermometer
Kurokawa, M.; Higashi, K.; Yoshida, K.; Sato, T.; Maruyama, S.; Mori, H.; Kurokawa, K.
10.1101/2022.07.14.499854 — bioinformatics — Posted on 2022-07-16
1948 Bird assemblages in a peri-urban landscape in eastern India
Karjee, R.; Palei, H. S.; Konwar, A.; Gogoi, A.; Mishra, R. K.
10.1101/2022.07.14.500013 — ecology — Posted on 2022-07-16
1950 Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system
Dazzoni, R.; Li, Y.; Lopez-Castilla, A.; Brier, S.; Mechaly, A.; Cordier, F.; Haouz, A.; Nilges, M.; Francetic, O.; Bardiaux, B.; Izadi-Pruneyre, N.
10.1101/2022.07.16.500195 — microbiology — Posted on 2022-07-16
1951 DIETARY PROTECTION AGAINST THE VISUAL AND MOTOR DEFICITS INDUCED BY EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Zyla-Jackson, K.; Walton, D. A.; Plafker, K. S.; Kovats, S.; Georgescu, C.; Brush, R. S.; Tytanic, M.; Agbaga, M.-P.; Plafker, S. M.
10.1101/2022.07.13.499958 — immunology — Posted on 2022-07-16
1952 Modulatory dynamics of periodic and aperiodic activity in respiration-brain coupling
Kluger, D. S.; Forster, C.; Abbasi, O.; Chalas, N.; Villringer, A.; Gross, J.
10.1101/2022.07.14.500026 — neuroscience — Posted on 2022-07-16
1955 A stable, distributed code for cue value in mouse cortex during reward learning
Ottenheimer, D. J.; Hjort, M. M.; Bowen, A. J.; Steinmetz, N. A.; Stuber, G. D.
10.1101/2022.07.13.499930 — neuroscience — Posted on 2022-07-16
1959 The breast cancer pro-metastatic phenotype requires concomitant hyper-activation of ECM remodeling and dsRNA-IFN1 signaling in rare clone cells
Roda, N.; Cossa, A.; Hillje, R.; Tirelli, A.; Ruscitto, F.; Cheloni, S.; Priami, C.; Dalmasso, A.; Gambino, V.; Blandano, G.; Polazzi, A.; Falvo, P.; Gatti, E.; Mazzarella, L.; Luzi, L.; Migliaccio, E.; Pelicci, P. G.
10.1101/2022.07.13.499961 — cancer biology — Posted on 2022-07-16
1961 Generalising uncertainty improves accuracy and safety of deep learning analytics applied to oncology
MacDonald, S.; Foley, H.; Yap, M.; Johnston, R. L.; Steven, K.; Koufariotis, L. T.; Sharma, S.; Wood, S.; Addala, V.; Pearson, J.; Roosta, F.; Waddell, N.; Kondrashova, O.; Trzaskowski, M.
10.1101/2022.07.14.500142 — bioinformatics — Posted on 2022-07-16
1962 Deep-Learning for Automated Markerless Tracking of Infants General Movements
Abbasi, H.; Mollet, S.; Williams, S.; Lim, L.; Battin, M.; Besier, T. F.; McMorland, A.
10.1101/2022.07.13.499984 — bioengineering — Posted on 2022-07-16
1964 Multi-chamber cardioids unravel human heart development and cardiac defects
Schmidt, C.; Deyett, A.; Ilmer, T.; Caballero, A. T.; Haendeler, S.; Pimpale, L.; Netzer, M. A.; Ginistrelli, L. C.; Cirigliano, M.; Mancheno, E. J.; Reumann, D.; Tavernini, K.; Hering, S.; Hofbauer, P.; Mendjan, S.
10.1101/2022.07.14.499699 — developmental biology — Posted on 2022-07-16
1965 FrangiPANe, a tool for creating a panreference using left behind reads
Tranchant-Dubreuil, C.; Chenal, C.; Blaison, M.; Albar, L.; Klein, V.; Mariac, C.; Wing, R. A.; Vigouroux, y.; Sabot, F.
10.1101/2022.07.14.499848 — plant biology — Posted on 2022-07-16
1966 A role for brassinosteroid signaling in decision-making processes in the Arabidopsis seedling
Kalbfuss, N.; Strohmayr, A.; Kegel, M.; Le, L.; Grosseholz, F.; Brunschweiger, B.; Stoeckl, K.; Wiese, C.; Franke, C.; Schiestl, C.; Prem, S.; Sha, S.; Franz-Oberdorf, K.; Hafermann, J.; Thieme, M. A.; Facher, E.; Palubicki, W.; Bolle, C.; Assaad, F. F.
10.1101/2022.07.15.499689 — plant biology — Posted on 2022-07-16
1967 Impact of storage on starch digestibility and texture of a high-amylose wheat bread
Corrado, M.; Zafeiriou, P.; Ahn-Jarvis, J. H.; Savva, G. M.; Edwards, C. H.; Hazard, B. A.
10.1101/2022.07.04.498686 — biochemistry — Posted on 2022-07-16
1968 Complex multiple introductions drive fall armyworm invasions into Asia and Australia
Rane, R.; Walsh, T.; Lenancker, P.; Gock, A.; Hang, D. T.; Liem, N. V.; Khin, T. N.; Amalin, D.; Chittarath, K.; Faheem, M.; Sivapragasam, A.; Thanarajoo, S. S.; Trisyono, Y. A.; Khay, S.; Kim, J.; Kuniata, L.; Powell, K.; Kalyebi, A.; Otim, M.; Nam, K.; d'Alencon, E.; Gordon, K.; Tay, W. T.
10.1101/2022.06.11.495773 — evolutionary biology — Posted on 2022-07-16
1969 Pharmacogenetic variation in Neanderthals and Denisovans and implications for human health and response to medications
Wroblewski, T. H.; Witt, K. E.; Lee, S.-b.; Malhi, R. S.; Huerta-Sanchez, E.; Villanea, F.; Claw, K. G.
10.1101/2021.11.27.470071 — evolutionary biology — Posted on 2022-07-16
1971 Human CD4/CD8 double positive T cells are both predictive and sufficient to mediate GVHD pathology
Hess, N. J.; Turicek, D. P.; Riendeau, J.; McIlwain, S.; Contreras Guzman, E.; Nadiminti, K.; Hudson, A.; Callander, N. S.; Skala, M. C.; Gumperz, J. E.; Hematti, P.; Capitini, C. M.
10.1101/2022.01.11.475845 — immunology — Posted on 2022-07-16
1972 Exotic alleles of EARLY FLOWERING 3 determine plant development and grain yield in barley
Zahn, T.; Zhu, Z.; Ritoff, N.; Krapf, J.; Junker, A.; Altmann, T.; Schmutzer, T.; Tueting, C.; Kastritis, P. L.; Quint, M.; Pillen, K.; Maurer, A.
10.1101/2022.07.15.500212 — genetics — Posted on 2022-07-16
1976 Aberrant extracellular matrix and cardiac development in models lacking the PR-DUB component ASXL3
McGrath, B. T.; Tsan, Y. C.; Salvi, S.; Ghali, N.; Martin, D. M.; Hannibal, M.; Keegan, C. E.; Helms, A.; Srivastava, A.; Bielas, S. L.
10.1101/2022.07.14.500124 — developmental biology — Posted on 2022-07-16
1977 Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition
Chann, A. S.; Charnley, M.; Newton, L. M.; Newbold, A.; Humbert, P. O. O.; Johnstone, R. W.; Russell, S.; Tiganis, T.; Wiede, F.
10.1101/2021.10.03.462949 — developmental biology — Posted on 2022-07-16
1979 Mapping PTBP splicing in human brain identifies targets for therapeutic splice switching including SYNGAP1
Dawicki-McKenna, J. M.; Felix, A. J.; Waxman, E. A.; Cheng, C.; Amado, D. A.; Ranum, P. T.; Bogush, A.; Dungan, L. V.; Heller, E. A.; French, D. L.; Davidson, B. L.; Prosser, B. L.
10.1101/2022.07.15.500219 — molecular biology — Posted on 2022-07-16
1981 Melanoma cells appropriate pericyte:endothelial cell crosstalk during perivascular invasion in the brain
Zhang, Y.; Riedstra, C. P.; Wang, S.; Patel, S.; Bald, T.; Kumar, P.; Rohani, A.; Kashatus, D.; Moschos, S.; Dudley, A. C.
10.1101/2022.07.15.500231 — cancer biology — Posted on 2022-07-15
1984 Tra1 controls the transcriptional landscape of the aging cell
Bari, K. A.; Berg, M. D.; Genereaux, J.; Brandl, C. J.; Lajoie, P.
10.1101/2022.07.13.499971 — genetics — Posted on 2022-07-15
1988 The Brain natriuretic peptide improves the heart regeneration after infarction by stimulating the cardiomyocyte renewal
Bon-Mathier, A.-C.; Deglise, T.; Stephanie, R.-C.; Christelle, B.; Mazzolai, L.; Rosenblatt-Velin, N.
10.1101/2022.07.14.500057 — cell biology — Posted on 2022-07-15
1990 Intralumenal docking of Cx36 channels in the ER isolates mis-trafficked protein
Tetenborg, S.; Liss, V.; Breitsprecher, L.; Timonina, K.; Kotova, A.; Hecker, A. J. A.; Yuan, C.; Shihabeddin, E.; Dedek, K.; Zoidl, G.; Hensel, M.; O`Brien, J.
10.1101/2022.07.15.500247 — cell biology — Posted on 2022-07-15
1991 Telomere dysfunction impairs intestinal differentiation andpredisposes to diet-induced colitis
Engevik, M.; Guo, L.; Song, W.-S.; Chronowski, C.; Akhanov, V.; Bosquez, N.; Engevik, A.; Oezguen, N.; Coarfa, C.; Putluri, N.; Catic, A.; Baur, J.; Finegold, M.; Shroyer, N.; Gu, J.; Ferraris, R.; Halliday, J.; Herman, C.; Colla, S.; Dierick, H.; Jang, C.; Sahin, E.
10.1101/2022.07.14.499988 — cell biology — Posted on 2022-07-15
1992 High-Throughput Functional Assay in Cystic Fibrosis Patient-Derived Organoids Allows Drug Repurposing
Spelier, S.; de Poel, E.; Ithakisiou, G. N.; Suen, S.; Hagemeijer, M.; Muijlwijk, D.; Vonk, A.; Brunsveld, J.; Kruisselbrink, E.; van der Ent, K.; Beekman, J.
10.1101/2022.07.14.500147 — cell biology — Posted on 2022-07-15
1994 Regulated Degradation of the Inner Nuclear Membrane Protein SUN2 Maintains Nuclear Envelope Architecture and Function
Krshnan, L.; Siu, W. S.; Van de Weijer, M.; Hayward, D.; Guerrero, E. N.; Gruneberg, U.; Carvalho, P.
10.1101/2022.07.15.500172 — cell biology — Posted on 2022-07-16
1998 Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions
Sugita, K.; Onishi, I.; Nakayama, R.; Ishibashi, S.; Ikeda, M.; Inoue, M.; Narita, R.; Oshima, S.; Shimizu, K.; Saito, S.; Sato, S.; Moriarity, B. S.; Yamamoto, K.; Largaespada, D.; Kitagawa, M.; Kurata, M.
10.1101/2022.07.15.500173 — cancer biology — Posted on 2022-07-15
2000 The difference in FRET efficiency fluctuation at each end of the actin filament
Mitani, T.; Mashiko, R.; Nezasa, M.; Nishikata, I.; Kamimura, K.; Honda, H.; Fujiwara, I.
10.1101/2022.07.15.500159 — biophysics — Posted on 2022-07-15
2005 HMGN5, an RNA or Nucleosome binding protein - potentially switching between the substrates to regulate gene expression
Araya, I.; Nardocci, G.; Schwartz, U.; Babl, S.; Barros, M.; Carrasco-Wong, I.; Imhof, A.; Montecino, M.; Langst, G.
10.1101/2022.07.15.500188 — molecular biology — Posted on 2022-07-15
2008 A case of mycobacteriosis associated with Mycobacterium pseudoshottsii in aquarium-reared fish in Japan
Komine, T.; Hyogo, I.; Kentaro, O.; Yoshida, M.; Sugimoto, Y.; Inohana, M.; Fukano, H.; Kurata, O.; Wada, S.
10.1101/2022.07.14.500145 — microbiology — Posted on 2022-07-15
2010 Expanding the scope of bacterial CRISPR activation with PAM-flexible dCas9 variants
Kiattisewee, C.; Karanjia, A. V.; Legut, M.; Daniloski, Z.; Koplik, S. E.; Nelson, J.; Kleinstiver, B. P.; Sanjana, N. E.; Carothers, J. M.; Zalatan, J. G.
10.1101/2022.07.14.500123 — synthetic biology — Posted on 2022-07-15
2012 DNA damage and somatic mutations engraved on the genomes of mammalian cells after irradiation with a nail polish dryer
Zhivagui, M.; Hoda, A.; Valenzuela, N.; Yeh, Y.-Y.; Dai, J.; He, Y.; Van Houten, B.; Alexandrov, L. B.
10.1101/2021.02.03.429605 — cancer biology — Posted on 2022-07-15
2016 CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles
Mueller, B. D.; Merrill, S. A.; Watanabe, S.; Liu, P.; Singh, A.; Maldonado-Catala, P.; Cherry, A.; Silva, M.; Wang, Z.-W.; Maricq, V. A.; Jorgensen, E. M.
10.1101/2022.05.03.490438 — neuroscience — Posted on 2022-07-15
2018 Discovering functionally important sites in proteins
Cagiada, M.; Bottaro, S.; Lindemose, S.; Schenstrom, S. M.; Stein, A.; Hartmann-Petersen, R.; Lindorff-Larsen, K.
10.1101/2022.07.14.500015 — biophysics — Posted on 2022-07-15
2020 Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury
Liss, K. H. H.; Mousa, M.; Bucha, S.; Lutkewitte, A. J.; Allegood, J.; Cowart, L. A.; Finck, B.
10.1101/2022.07.10.499482 — biochemistry — Posted on 2022-07-15
2021 Accurate simultaneous sequencing of genetic and epigenetic bases in DNA
Fullgrabe, J.; Gosal, W. S.; Creed, P.; Liu, S.; Lumby, C. K.; Morley, D. J.; Ost, T. W. B.; Vilella, A. J.; Yu, S.; Bignell, H.; Burns, P.; Charlesworth, T.; Fu, B.; Fordham, H.; Harding, N.; Gandelman, O.; Golder, P.; Hodson, C.; Li, M.; Lila, M.; Liu, Y.; Mason, J.; Mellad, J.; Monahan, J.; Nentwich, O.; Palmer, A.; Steward, M.; Taipale, M.; Vandomme, A.; San-Bento, R. S.; Singhal, A.; Vivian, J.; Wojtowicz, N.; Williams, N.; Walker, N. J.; Wong, N. C. H.; Yalloway, G.; Holbrook, J. D.; Balasubramanian, S.
10.1101/2022.07.08.499285 — genomics — Posted on 2022-07-15
2024 In-depth study of tomato and weed viromes reveals undiscovered plant virus diversity in an agroecosystem
Rivarez, M. P. S.; Pecman, A.; Bacnik, K.; Maksimovic Carvalho Ferreira, O.; Vucurovic, A.; Seljak, G.; Mehle, N.; Gutierrez-Aguirre, I.; Ravnikar, M.; Kutnjak, D.
10.1101/2022.06.30.498278 — ecology — Posted on 2022-07-15
2026 Recovery of neural dynamics criticality in personalized whole brain models of stroke
Rocha, R. P.; Kocillari, L.; Suweis, S.; De Grazia, M. D. F.; Thiebaut de Schotten, M.; Zorzi, M.; Corbetta, M.
10.1101/2020.12.17.423349 — neuroscience — Posted on 2022-07-15
2028 Highly-Automated, High-Throughput Replication of Yeast-based Logic Circuit Design Assessments
Goldman, R. P.; Moseley, R.; Roehner, N.; Cummins, B.; Vrana, J. D.; Clowers, K. J.; Bryce, D.; Beal, J.; DeHaven, M.; Nowak, J.; Higa, T.; Biggers, V.; Lee, P.; Hunt, J. P.; Haase, S. B.; Weston, M.; Zheng, G.; Deckard, A.; Gopaulakrishnan, S.; Stubbs, J. F.; Gaffney, N. I.; Vaughn, M. W.; Maheshri, N.; Mikhalev, E.; Bartley, B.; Markeloff, R.; Mitchell, T.; Nguyen, T.; Sumorok, D.; Walczak, N.; Myers, C.; Zundel, Z.; Hatch, B.; Scholz, J.; Colonna-Romano, J.
10.1101/2022.05.31.493627 — synthetic biology — Posted on 2022-07-15
2029 Regulation of metabolic health by dietary histidine in mice
Flores, V.; Spicer, A. B.; Sonsalla, M.; Richardson, N. E.; Yu, D.; Sheridan, G. E.; Trautman, M. E.; Babygirija, R.; Cheng, E. P.; Rojas, J. M.; Yang, S. E.; Wakai, M. H.; Hubbell, R.; Kasza, I.; Tomasiewicz, J. L.; Green, C. L.; Dantoin, C.; Alexander, C. M.; Baur, J. A.; Malecki, K. C.; Lamming, D.
10.1101/2022.04.24.489217 — physiology — Posted on 2022-07-15
2030 Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer
Alshehri, S.; Pavlovic, T.; Farsinejad, S.; Behboodi, P.; Quan, L.; Centeno, D.; Kung, D.; Rezler, M.; Lee, W.; Jasinski, P.; Dziabaszewska, E.; Nowak-Markwitz, E.; Kalyon, D.; Zaborowski, M.; Iwanicki, M.
10.1101/2022.01.30.478322 — cancer biology — Posted on 2022-07-15
2031 Rapid protein stability prediction using deep learning representations
Blaabjerg, L. M.; Kassem, M. M.; Good, L. L.; Jonsson, N.; Cagiada, M.; Johansson, K. E.; Boomsma, W.; Stein, A.; Lindorff-Larsen, K.
10.1101/2022.07.14.500157 — biophysics — Posted on 2022-07-15
2036 Stretch Regulates Alveologenesis Via Mesenchymal Gαq/11-Mediated TGFβ2 Activation
Goodwin, A. T.; John, A. E.; Joseph, C.; Habgood, A.; Tatler, A. L.; Susztak, K.; Palmer, M.; Offermanns, S.; Henderson, N. C.; Jenkins, G.
10.1101/2020.09.06.284778 — developmental biology — Posted on 2022-07-15
2037 A Novel Homeostatic Mechanism Tunes PI(4,5)P2-dependent Signaling at the Plasma Membrane
Wills, R. C.; Doyle, C. P.; Zewe, J. P.; Pacheco, J.; Hansen, S. D.; Hammond, G. R.
10.1101/2022.06.30.498262 — cell biology — Posted on 2022-07-15
2039 Regulation of neuronal mRNA splicing and Tau isoform ratio by ATXN3 through deubiquitylation of splicing factors
Neves-Carvalho, A.; Duarte-Silva, S.; Silva, J. M.; Meireles-Costa, L.; Monteiro-Fernandes, D.; Correia, J. S.; Rodrigues, B.; Heetveld, S.; Almeida, B.; Savytska, N.; Da Silva, J. D.; Teixeira-Castro, A.; Sotiropoulos, I.; Carvalho, A. L.; Heutink, P.; Li, K. W.; Maciel, P.
10.1101/711424 — neuroscience — Posted on 2022-07-15
2040 Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys
Sanzeni, A.; Palmigiano, A.; Nguyen, T. H.; Luo, J.; Nassi, J. J.; Reynolds, J. H.; Histed, M. H.; Miller, K. D.; Brunel, N.
10.1101/2022.07.13.499597 — neuroscience — Posted on 2022-07-15
2044 Mink on the brink: Comparing survey methods for detecting a Critically Endangered carnivore, the European mink Mustela lutreola
Croose, E.; Hanniffy, R.; Harrington, A.; Podra, M.; Gomez, A.; Bolton, P. L.; Lavin, J. V.; Browett, S. S.; Ruiz, J. P.; Arnaez, D. L.; Galdos, I.; Ugarte, J.; Torre, A.; Wright, P.; MacPherson, J.; McDevitt, A. D.; Carter, S. P.; Harrington, L.
10.1101/2022.07.12.499692 — ecology — Posted on 2022-07-15
2046 Lasting alterations in monocyte and dendritic cell subsets in individuals after hospitalization for COVID-19
Hopkins, F. R.; Govender, M.; Svanberg, C.; Nordgren, J.; Waller, H.; Nilsdotter-Augustinsson, A.; Henningsson, A. J.; Hagbom, M.; Sjowall, J.; Nystrom, S.; Larsson, M.
10.1101/2022.07.15.500185 — immunology — Posted on 2022-07-15
2048 Genome-first detection of emerging resistance to novel therapeutic agents for SARS-CoV-2
Ragonnet-Cronin, M.; Nutalai, R.; Huo, J.; Dijokaite-Guraliuc, A.; Das, R.; Tuekprakhon, A.; Supasa, P.; Liu, C.; Selvaraj, M.; Groves, N.; Hartman, H.; Ellaby, N.; Sutton, J. M.; Bahar, M. W.; Zhou, D.; Fry, E.; Ren, J.; Brown, C.; Klenerman, P.; Dunachie, S. J.; Mongkolsapaya, J.; Hopkins, S.; Chand, M.; Stuart, D. I.; Screaton, G. R.; Rokadiya, S.
10.1101/2022.07.14.500063 — genetics — Posted on 2022-07-15
2049 Neutralization sensitivity of Omicron BA.2.75 to therapeutic monoclonal antibodies
Yamasoba, D.; Kimura, I.; Kosugi, Y.; Uriu, K.; Fujita, S.; Ito, J.; Sato, K.; The Genotype to Phenotype Japan (G2P-Japan) Consortium,
10.1101/2022.07.14.500041 — microbiology — Posted on 2022-07-15
2050 Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE2 in both cell and in vivo mouse models
Zuo, Y.; Zheng, Z.; Huang, Y.; He, J.; Zang, L.; Ren, T.; Cao, X.; Miao, Y.; Yuan, Y.; Liu, Y.; Ma, F.; Tian, S.; Dai, J.; Ding, Q.; Zheng, H.
10.1101/2022.07.14.499651 — microbiology — Posted on 2022-07-15
2052 Ending transmission of SARS-CoV-2: sterilizing immunity using an intranasal subunit vaccine
Leekha, A.; Saeedi, A.; Sefat, S. R.; Kumar, M.; Paniagua, M. M.; Damian, A.; Kulkarni, R.; Rezvan, A.; Mosoumi, S.; Liu, X.; Cooper, L. J. N.; Sebastian, M.; Hurst, B. L.; Varadarajan, N.
10.1101/2022.07.14.500068 — immunology — Posted on 2022-07-15
2053 SARS-CoV-2 BA.4 infection triggers more cross-reactive neutralizing antibodies than BA.1
Richardson, S.; Motlou, T.; van der Mescht, M.; Lambson, B.; Everatt, J.; Amoako, D.; Van Gottberg, A.; Wolter, N.; de Beer, Z.; Roma de Villiers, T.; Bodenstein, A.; van den Berg, G.; Rossouw, T. M.; Boswell, M.; Ueckermann, V.; Bhiman, J.; Moore, P.
10.1101/2022.07.14.500039 — immunology — Posted on 2022-07-15
2054 Fc effector activity and neutralization against SARS-CoV-2 BA.4 is compromised in convalescent sera, regardless of the infecting variant
Richardson, S.; Kgagudi, P.; Manamela, N. P.; Kaldine, H.; Venter, E.; Pillay, T.; Lambson, B. E.; van der Mescht, M.; Hermanus, T.; de Beer, Z.; de Villier, T.; Bodenstein, A.; van den Berg, G.; du Pisanie, M.; Burgers, W.; Ntusi, N. A. B.; Ueckermann, V.; Rossouw, T.; Boswell, M.; Moore, P.
10.1101/2022.07.14.500042 — immunology — Posted on 2022-07-15
2056 No evidence that synonymous mutations in yeast genes are mostly deleterious
Kruglyak, L.; Beyer, A.; Bloom, J. S.; Grossbach, J.; Lieberman, T. D.; Mancuso, C. P.; Rich, M. S.; Sherlock, G. J.; van Nimwegen, E. J.; Kaplan, C. D.
10.1101/2022.07.14.500130 — genetics — Posted on 2022-07-15
2057 FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase
Chakraborty, A.; Dutta, A.; Dettori, L. G.; Li, J.; Gonzalez, L.; Xue, X.; Hehnly, H.; Sung, P.; Bah, A.; Feng, W.
10.1101/2022.07.10.499475 — biochemistry — Posted on 2022-07-15
2063 Dynamic chromosomal interactions and control of heterochromatin positioning by Ki67
van Schaik, T.; Manzo, S. G.; Vouzas, A. E.; Liu, N. Q.; Teunissen, H.; de Wit, E.; Gilbert, D. M.; van Steensel, B.
10.1101/2021.10.20.465140 — genomics — Posted on 2022-07-15
2065 Abundant trans-driven variation in detoxification gene expression in the extreme generalist herbivore Tetranychus urticae
Kurlovs, A. H.; De Beer, B.; Ji, M.; Vandenhole, M.; De Meyer, T.; Feyereisen, R.; Clark, R. M.; Van Leeuwen, T.
10.1101/2022.07.13.499853 — genetics — Posted on 2022-07-15
2067 TransCRISPR - sgRNA design tool for CRISPR/Cas9 experiments targeting DNA sequence motifs
Wozniak, T.; Sura, W.; Kazimierska, M.; Kasprzyk, M. E.; Podralska, M.; Dzikiewicz-Krawczyk, A.
10.1101/2022.04.05.487109 — molecular biology — Posted on 2022-07-15
2068 Genetic score omics regression and multi-trait meta-analysis detect widespread cis-regulatory effects shaping bovine complex traits
Xiang, R.; Fang, L.; Liu, S.; Gao, Y.; Liu, G. E.; Tenesa, A.; Mason, B. A.; Chamberlain, A. J.; Goddard, M. E.
10.1101/2022.07.13.499886 — genomics — Posted on 2022-07-15
2069 A low-cost and open-source solution to automate imaging and analysis of cyst nematode infection assays for Arabidopsis thaliana
Kranse, O. P.; Ko, I.; Healey, R.; Sonawala, U.; Wei, S.; Senatori, B.; De Batte, F.; Zhou, J.; Eves-van den Akker, S.
10.1101/2022.07.14.500020 — plant biology — Posted on 2022-07-15
2072 Transcriptional Profiling of the Hippocampus in an F2 Cross of a Genetic Rat Model of Internalizing vs. Externalizing Behavior and Addiction Liability
Hebda-Bauer, E. K.; Hagenauer, M. H.; Blandino, P.; Meng, F.; Chitre, A. S.; Ozel, A. B.; Arakawa, K.; Flagel, S. B.; Watson, S. J.; Palmer, A. A.; Li, J.; Akil, H.
10.1101/2022.07.14.500129 — neuroscience — Posted on 2022-07-15
2073 Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scale
Janaszkiewicz, A.; Toth, A.; Faucher, Q.; Arnion, H.; Vedrenne, N.; Barin-Le Guellec, C.; Marquet, P.; Di Meo, F.
10.1101/2022.07.14.500056 — pharmacology and toxicology — Posted on 2022-07-15
2075 Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase
Liu, Q.; Xu, J.; Zhou, R.; Wang, G.; Guo, Y.; Gao, X.; Zhou, S.; Ma, C.; Chen, L.; Shi, B.; Wang, H.; Wang, F.
10.1101/2022.07.14.500024 — genetics — Posted on 2022-07-15
2077 A minimal role for synonymous variation in human disease
Dhindsa, R. S.; Wang, Q.; Vitsios, D.; Burren, O. S.; Hu, F.; DiCarlo, J. E.; Kruglyak, L.; MacArthur, D. G.; Hurles, M. E.; Petrovski, S.
10.1101/2022.07.13.499964 — genetics — Posted on 2022-07-15
2080 ompC/F mutations drive XDR phenotype and lineage defining super clones of E. coli: Sequential events and consequences
Devanga Ragupathi, N. K.; Muthuirulandi Sethuvel, D. P.; Vasudevan, K.; Murugan, D.; Neeravi, A. R.; Bakthavatchalam, Y. D.; Velmurugan, A.; Walia, K.; Veeraraghavan, B.
10.1101/2022.07.14.500153 — genomics — Posted on 2022-07-15
2088 Disentangling the genomic complexity of the Fragilariopsis cylindrus (CCMP1102) genome
Hodgkinson, K. A.; Wright, J.; Garcia Accinelli, G.; Heavens, D.; Hopes, A.; Mock, T.; van Oosterhout, C.; Clavijo, B. J.
10.1101/2022.07.14.500034 — genomics — Posted on 2022-07-15
2091 The SPARC complex defines RNAPII promoters in Trypanosoma brucei
Staneva, D. P.; Bresson, S.; Auchynnikava, T.; Spanos, C.; Rappsilber, J.; Jeyaprakash, A. A.; Tollervey, D.; Matthews, K. R.; Allshire, R. C.
10.1101/2022.07.14.499694 — molecular biology — Posted on 2022-07-15
2092 Degraded RNA from human anterior cruciate ligaments yields valid gene expression profiles
Strawn, M. D.; Fisher, G. D.; Perry, C. J.; Hashemi, J.; Mansouri, H.; Ferguson, M. P.; Zumwalt, M.; Brindley, G. W.; Slauterbeck, J. R.; Hardy, D. M.
10.1101/2022.07.14.500070 — molecular biology — Posted on 2022-07-15
2093 Identification of circRNAs linked to Alzheimer's disease and related dementias
Puri, S.; Hu, J.; Sun, Z.; Lao, M.; Stein, T.; Farrer, L.; Wolozin, B.; Zhang, X.
10.1101/2022.07.13.499937 — molecular biology — Posted on 2022-07-15
2095 Melanization of Candida auris is Associated with Alteration of Extracellular pH
Smith, D. F. Q.; Mudrak, N. J.; Zamith-Miranda, D.; Honorato, L.; Nimrichter, L.; Smith, B.; Gerfen, G. J.; Nosanchuk, J. D.; Casadevall, A.
10.1101/2022.07.14.500134 — microbiology — Posted on 2022-07-15
2096 Inhibiting circRNA Cdr1as expression in the ILPFC of adult male C57BL/6J mice impairs fear extinction memory
Zajaczkowski, E. L.; Zhao, Q.; Liau, W.-S.; Gong, H.; Madugalle, S. U.; Periyakaruppiah, A.; Leighton, L. J.; Musgrove, M.; Ren, H.; Davies, J.; Marshall, P.; Bredy, T.
10.1101/2022.07.14.500137 — neuroscience — Posted on 2022-07-15
2098 Pannexin 3 channels regulate architecture, adhesion, barrier function and inflammation in the skin
O'Donnell, B. L.; Sanchez-Pupo, R. E.; Sayedyahossein, S.; Karimi, M.; Bahmani, M.; Zhang, C.; Johnston, D.; Kelly, J.; Wakefield, C. B.; Barr, K.; Dagnino, L.; Penuela, S.
10.1101/2022.07.13.499920 — cell biology — Posted on 2022-07-14
2101 OptoPi: An open source flexible platform for the analysis of small animal behaviour
Cano-Ferrer, X.; Roberts, R. J. V.; French, A. S.; de Folter, J.; Gong, H.; Nightingale, L.; Strange, A.; Imbert, A.; Prieto-Godino, L. L.
10.1101/2022.07.12.499786 — neuroscience — Posted on 2022-07-14
2102 ROR1 plays a critical role in pancreatic tumor-initiating cells with a partial EMT signature.
Yamazaki, M.; Hino, S.; Usuki, S.; Miyazaki, Y.; Oda, T.; Nakao, M.; Ito, T.; Yamagata, K.
10.1101/2022.07.13.499868 — cancer biology — Posted on 2022-07-14
2103 Evolution of ipsilateral breast cancer decoded by proteogenomics
De Marchi, T.; Pyl, P. T.; Sjostrom, M.; Reinsbach, S. E.; DiLorenzo, S.; Nystedt, B.; Tran, L.; Pekar, G.; Warnberg, F.; Fredriksson, I.; Malmstrom, P.; Ferno, M.; Malmstrom, L.; Malmstrom, J.; Nimeus, E.
10.1101/2022.07.13.499898 — cancer biology — Posted on 2022-07-14
2106 How do tuna schools associate to dFADs? A study usingecho-sounder buoys to identify global patterns
Navarro-Garcia, M.; Precioso, D.; Gavira-O'Neill, K.; Torres-Barran, A.; Gordo, D.; Gallego, V.; Gomez-Ullate, D.
10.1101/2022.07.14.500080 — bioinformatics — Posted on 2022-07-14
2110 Interactive analysis of single-cell data using flexible workflows with SCTK2.0
Wang, Y.; Sarfraz, I.; Hong, R.; Koga, Y.; Akavoor, V.; Cao, X.; Alabdullatif, S.; Pervaiz, N.; Zaib, S. A.; Wang, Z.; Jansen, F.; Yajima, M.; Johnson, W. E.; Campbell, J. D.
10.1101/2022.07.13.499900 — bioinformatics — Posted on 2022-07-14
2113 Combinatorial microRNA loading into extracellular vesicles for anti-inflammatory therapy
Pottash, A. E.; Levy, D.; Jeyaram, A.; Kuo, L.; Kronstadt, S. M.; Chao, W.; Jay, S. M.
10.1101/2022.07.13.499941 — bioengineering — Posted on 2022-07-14
2115 Modular automated microfluidic cell culture platform reduces glycolytic stress in cerebral cortex organoids
Seiler, S. T.; Mantalas, G. L.; Selberg, J.; Cordero, S.; Torrse-Montoya, S.; Baudin, P. V.; Ly, V. T.; Amend, F.; Tran, L.; Hoffman, R. N.; Rolandi, M.; Green, R. E.; Haussler, D.; Salama, S. R.; Teodorescu, M.
10.1101/2022.07.13.499938 — bioengineering — Posted on 2022-07-14
2116 Cryo-EM structure of a RAS/RAF recruitment complex
Eck, M. J.; Jeon, H.; Park, E.; Rawson, S.; Schmoker, A.; Kim, B.-W.; Oh, S.; Song, K.
10.1101/2022.07.14.500081 — biochemistry — Posted on 2022-07-14
2119 Epigenetic markers of adverse lifestyle identified among night shift workers
Hulls, P. M.; McCartney, D. L.; Bao, Y.; Walker, R. M.; de Vocht, F.; Martin, R. M.; Relton, C. L.; Evans, K. L.; Kumari, M.; Marioni, R. E.; Richmond, R. C.
10.1101/2022.07.13.499754 — genetics — Posted on 2022-07-14
2120 Abundant trans-driven variation in detoxification gene expression in the extreme generalist herbivore Tetranychus urticae
Kurlovs, A. H.; De Beer, B.; Ji, M.; Vandenhole, M.; De Meyer, T.; Feyereisen, R.; Clark, R. M.; Van Leeuwen, T.
10.1101/2022.07.13.499853 — genetics — Posted on 2022-07-14
2124 Molecular characterization of the intact muscle spindle using a multi-omics approach
Bornstein, B.; Heinemann-Yerushalmi, L.; Krief, S.; Adler, R.; Dassa, B.; Leshkowitz, D.; Kim, M.; Bewick, G.; Banks, R. W.; Zelzer, E.
10.1101/2022.07.13.499888 — developmental biology — Posted on 2022-07-14
2125 Visualization of Retroplacental Clear Space Disruption in a Mouse Model of Placental Accreta
Badachhape, A. A.; Bhandari, P.; Devkota, L.; Srivastava, M.; Tanifum, E. A.; George, V.; Fox, K. A.; Yallampalli, C.; Annapragada, A. V.; Ghaghada, K.
10.1101/2022.07.12.499572 — developmental biology — Posted on 2022-07-14
2127 Rewiring Dynamics of Functional Connectome in Motor Cortex during Motor Skill Learning
Meamardoost, S.; Hwang, E.; Bhattacharya, M.; Ren, C.; Wang, L.; Mewes, C.; Zhang, Y.; Komiyama, T.; Gunawan, R.
10.1101/2022.07.12.499746 — neuroscience — Posted on 2022-07-14
2129 Multiscale cosimulation design template implemented for a neuroscience application
Kusch, L.; Diaz, S.; Klijn, W.; Sontheimer, K.; Bernard, C.; Morrison, A.; Jirsa, V.
10.1101/2022.07.13.499940 — neuroscience — Posted on 2022-07-14
2130 Molecular recording of calcium signaling via calcium-dependent protein proximity labeling
Kim, J. W.; Yong, A. J. H.; Dawson, T. M.; Dawson, V. L.; Jan, Y.-N.; Ingolia, N. T.
10.1101/2022.07.14.500122 — neuroscience — Posted on 2022-07-14
2131 Systematic comparison of culture media uncovers phenotypic shift of human microglia defined by reduced reliance to CSF1R signaling
Dorion, M.-F.; Yaqubi, M.; Murdoch, H. J.; Hall, J.; Dudley, R.; Antel, J. P.; Durcan, T. M.; Healy, L. M.
10.1101/2022.07.14.500101 — neuroscience — Posted on 2022-07-14
2133 B1+-correction of MT saturation maps optimized for 7T postmortem MRI of the brain
Lipp, I.; Kirilina, E.; Edwards, L. J.; Pine, K. J.; Jaeger, C.; Graessle, T.; EBC consortium, ; Weiskopf, N.; Helms, G.
10.1101/2022.07.12.498197 — neuroscience — Posted on 2022-07-14
2137 Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise
Polyak, A.; Topal, L.; Prorok, J.; Toth, N.; Kohajda, Z.; Deri, S.; Demeter-Haludka, V.; Hegyi, P.; Venglovecz, V.; Sarusi, A.; Agoston, G.; Husti, Z.; Zombori-Toth, N.; Gazdag, P.; Szlovak, J.; Arpadffy-Lovas, T.; Naveed, M.; Jost, N.; Virag, L.; Nagy, N.; Baczko, I.; Farkas, A. S.; Varro, A.
10.1101/2022.07.13.499876 — physiology — Posted on 2022-07-14
2138 Postnatal protein intake as a determinant of skeletal muscle structure and function in mice - a pilot study
Kanakis, I.; Giakoumaki, I.; Pollock, N.; Aljuaid, T.; Sanicandro, A. J.; Alameddine, M.; Owen, E.; Myrtziou, I.; E. Ozanne, S.; Goljanek-Whysall, K.; Vasilaki, A.
10.1101/2022.07.13.499936 — physiology — Posted on 2022-07-14
2140 Reference compounds for characterizing cellular injury in high-content cellular morphology assays
Dahlin, J. L.; Hua, B. K.; Zucconi, B. E.; Nelson, S. D.; Singh, S.; Carpenter, A. E.; Shrimp, J. H.; Lima-Fernandes, E.; Wawer, M. J.; Chung, L. P.; Agrawal, A.; O'Reilly, M.; Barsyte-Lovejoy, D.; Szewczyk, M.; Li, F.; Lak, P.; Cuellar, M.; Cole, P. A.; Meier, J. L.; Thomas, T.; Baell, J. B.; Brown, P. J.; Walters, M. A.; Clemons, P. A.; Schreiber, S. L.; Wagner, B. K.
10.1101/2022.07.12.499781 — pharmacology and toxicology — Posted on 2022-07-14
2143 A hybrid approach for predicting transcription factors
Patiyal, S.; Tiwari, P.; Ghai, M.; Dhapola, A.; Dhall, A.; Raghava, G. P. S.
10.1101/2022.07.13.499865 — bioinformatics — Posted on 2022-07-14
2152 An algorithm to detect abnormal mRNA splicing and assess its clinical impact in individuals undergoing genetic testing for hereditary cancer syndromes
Kamps-Hughes, N.; Carlton, V.; Fresard, L.; Osazuwa, S.; Starks, E.; Vincent, J. J.; Albritton, S.; Nussbaum, R. L.; Nykamp, K.
10.1101/2022.07.12.499782 — genetics — Posted on 2022-07-14
2153 Microstructural and crystallographic evolution of palaeognath (Aves) eggshells
Choi, S.; Hauber, M. E.; Legendre, L. J.; Kim, N.-H.; Lee, Y.-N.; Varricchio, D. J.
10.1101/2022.07.12.499761 — evolutionary biology — Posted on 2022-07-14
2158 Multi-omics analyses identify transcription factor interplay in corneal epithelial fate determination and disease
Smits, J.; Cunha, D. L.; Qu, J.; Owen, N.; Latta, L.; Szentmary, N.; Seitz, B.; Roux, L. N.; Moosajee, M.; Aberdam, D.; van Heeringen, S. J.; Zhou, H.
10.1101/2022.07.13.499857 — developmental biology — Posted on 2022-07-14
2160 Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies
Lee, C.-Y.; Caceres, C. J.; Geiger, G.; Seibert, B.; Faccin, F. C.; Gay, L. C.; Ferreri, L. M.; Kaul, D.; Wrammert, J.; Tan, G. S.; Perez, D. R.; Lowen, A. C.
10.1101/2022.07.14.500125 — microbiology — Posted on 2022-07-14
2162 Single cell transcriptomics of Atlantic salmon (Salmo salar L.) liver reveals cellular heterogeneity and immunological responses to challenge by Aeromonas salmonicida
Taylor, R. S.; Ruiz Daniels, R.; Dobie, R.; Naseer, S.; Clark, T. C.; Henderson, N. C.; Boudinot, P.; Martin, S. A.; Macqueen, D. J.
10.1101/2022.07.12.498799 — immunology — Posted on 2022-07-14
2164 Interrelated effects of age and parenthood on whole-brain controllability: protective effects of parenthood in mothers
Jamalabadi, H.; Hahn, T.; Winter, N. R.; Ernsting, J.; Meinert, S.; Leehr, E.; Dohm, K.; Bauer, J.; Pfarr, J.-K.; Stein, F.; Thomas-Odenthal, F.; Brosch, K.; Mauritz, M.; Gruber, M.; Repple, J.; Kaufmann, T.; Krug, A.; Nenadic, I.; Kircher, T.; Dannlowski, U.; Derntl, B.
10.1101/2022.07.13.499891 — neuroscience — Posted on 2022-07-14
2165 Fine-scale measurement of the blind spot borders
Meermeier, A.; Lappe, M.; Rifai, K.; Wahl, S.; Rucci, M.
10.1101/2022.07.13.499892 — neuroscience — Posted on 2022-07-14
2166 Single-cell triple-omics uncovers DNA methylation as key feature of stemness in the healthy and ischemic adult brain
Kremer, L. P.; Cerrizuela, S.; Al Shukairi, M. E.; Ellinger, T.; Straub, J.; Dehler, S.; Korkmaz, A.; Weichenhan, D.; Plass, C.; Anders, S.; Martin-Villalba, A.
10.1101/2022.07.13.499860 — neuroscience — Posted on 2022-07-14
2173 CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles
Mueller, B. D.; Merrill, S. A.; Watanabe, S.; Liu, P.; Singh, A.; Maldonado-Catala, P.; Cherry, A.; Silva, M.; Wang, Z.-W.; Maricq, V. A.; Jorgensen, E. M.
10.1101/2022.05.03.490438 — neuroscience — Posted on 2022-07-14
2175 Efficient 3D light-sheet imaging of very large-scale optically cleared human brain and prostate tissue samples.
Schueth, A. A.; Hildebrand, S. S.; Samarska, I.; Sengupta, S.; Kiessling, A.; Herrler, A.; zur Hausen, A.; Capalbo, M.; Roebroeck, A.
10.1101/2022.07.14.500098 — neuroscience — Posted on 2022-07-14
2177 MIADE metadata guidelines: Minimum Information About a Disorder Experiment
Meszaros, B.; Hatos, A.; Palopoli, N.; Quaglia, F.; Salladini, E.; Van Roey, K.; Arthanari, H.; Dosztanyi, Z.; Felli, I. C.; Fischer, P. D.; Hoch, J.; Jeffries, C. M.; Longhi, S.; Maiani, E.; Orchard, S.; Pancsa, R.; Papaleo, E.; Pierattelli, R.; Pritisanac, I.; Viennet, T.; Tompa, P.; Vranken, W.; Tosatto, S. C.; Davey, N. E.
10.1101/2022.07.12.495092 — scientific communication and education — Posted on 2022-07-14
2182 Early life stress exposure increases susceptibility to high fat/high sucrose diet in female mice
Frick, J. M.; Eller, O. C.; Foright, R. M.; Levasseur, B. M.; Yang, X.; Wang, R.; Winter, M. K.; O'Neil, M.; Morris, E. M.; Thyfault, J. P.; Christianson, J. A.
10.1101/2022.07.14.500119 — physiology — Posted on 2022-07-14
2186 Thiol-mediated Uptake of a Cysteine-containing Nanobody for Anti-Cancer Drug Delivery
Goerdeler, F.; Reuber, E. E.; Luehle, J.; Leichnitz, S.; Freitag, A.; Nedielkov, R.; Moeller, H. M.; Seeberger, P. H.; Moscovitz, O.
10.1101/2022.07.12.497993 — cancer biology — Posted on 2022-07-14
2187 Advected percolation in the actomyosin cortex drives amoeboid cell motility
Garcia-Arcos, J. M.; Ziegler, J.; Grigolon, S.; Reymond, L.; Shajepal, G.; Cattin, C. J.; Lomakin, A.; Mueller, D. J.; Ruprecht, V.; Wieser, S.; Voituriez, R.; Piel, M.
10.1101/2022.07.14.500109 — biophysics — Posted on 2022-07-14
2198 Intrinsic linking of chromatin fiber in human cells
Borodzik, M.; Denkiewicz, M.; Spalinski, K.; Winnicka Sztachelska, K.; Sengupta, K.; Pilipczuk, M.; Pilipczuk, M.; Ruan, Y.; Plewczynski, D.
10.1101/2022.07.13.499767 — genomics — Posted on 2022-07-14
2201 Integrative genome-scale analyses reveal post-transcriptional signatures of early human smallintestinal development in a directed differentiation organoid model
Hung, Y.-H.; Capeling, M.; Villanueva, J. W.; Kanke, M.; Shanahan, M. T.; Huang, S.; Cubitt, R. L.; Rinaldi, V. D.; Schimenti, J. C.; Spence, J. R.; Sethupathy, P.
10.1101/2022.07.12.499825 — genomics — Posted on 2022-07-14
2202 Heteroplasmic Mitochondrial Genetic Variation in the Human Heart
Xue, L.; Sun, X.; Moreira, J. D.; Li, Y.; Smith, K. K.; Padera, R. F.; Lenburg, M. E.; Levy, D.; Benjamin, E. J.; Gopal, D. M.; Liu, C.; Fetterman, J. L.
10.1101/2022.07.13.499890 — genetics — Posted on 2022-07-14
2203 Cancer prevalence is remarkably low in turtles and is correlated with life history traits in birds, mammals, and squamates
Bulls, S.; Platner, L.; Ayub, W.; Moreno, N.; Arditi, J.-P.; McCain, S.; Wagner, P.; Bruins - van Sonsbeek, L. G. R.; Lynch, V. J.; Claude, J.; Glaberman, S.; Chiari, Y.
10.1101/2022.07.12.499088 — evolutionary biology — Posted on 2022-07-14
2206 Mink on the brink: Comparing survey methods for detecting a Critically Endangered carnivore, the European mink Mustela lutreola
Croose, E.; Hanniffy, R.; Harrington, A.; Podra, M.; Gomez, A.; Bolton, P. L.; Lavin, J. V.; Browett, S. S.; Ruiz, J. P.; Arnaez, D. L.; Galdos, I.; Ugarte, J.; Torre, A.; Wright, P.; MacPherson, J.; Carter, S. P.; Harrington, L.
10.1101/2022.07.12.499692 — ecology — Posted on 2022-07-14
2209 Neonatal hyperoxia induces sex-dependent pulmonary cellular and transcriptomic changes in an experimental mouse model of bronchopulmonary dysplasia
Xia, S.; Vila Ellis, L.; Winkley, K.; Menden, H.; Mabry, S. M.; Louiselle, D.; Gibson, M.; Grundberg, E.; Chen, J.; Sampath, V.
10.1101/2022.07.12.499826 — developmental biology — Posted on 2022-07-14
2211 Comprehensive characterization of toxins defines progression and stages in a non-human primate model of inhalation anthrax
Boyer, A. E.; Gallegos Candela, M.; Lins, R. C.; Solano, M. I.; Woolfitt, A. R.; Lee, J.; Sanford, D. C.; Knostman, K.; Quinn, C. P.; Hoffmaster, A. R.; Pirkle, J. L.; Barr, J. R.
10.1101/2022.07.13.499850 — microbiology — Posted on 2022-07-14
2214 Scale-free avalanches in humans NREM sleep and their relationships with sleep macro and microstructure
Scarpetta, S.; Morrisi, N.; Mutti, C.; Azzi, N.; Trippi, I.; Ciliento, R.; Apicella, I.; Lombardi, F.; Angiolelli, M.; Parrino, L.; Vaudano, A. E.
10.1101/2022.07.12.499725 — neuroscience — Posted on 2022-07-14
2217 PanomiR: A systems biology framework for analysis of multi-pathway targeting by miRNAs
Yeganeh, P. N.; Teo, Y. Y.; Karagkouni, D.; Pita-Juarez, Y.; Morgan, S. L.; Vlachos, I. S.; Hide, W.
10.1101/2022.07.12.499819 — systems biology — Posted on 2022-07-14
2218 A Glass Phase Plate for Wavelength SensitiveSuperresolution Microscopy
Fernando, S. I.; Martineau, J. T.; Vu, T. N.; Baker, B.; Hobson, R. J.; Mueller, B.; Menon, R.; Jorgensen, E. M.; Gerton, J. M.
10.1101/2022.07.11.499581 — biophysics — Posted on 2022-07-14
2222 GPCR-dependent spatiotemporal cAMP generation confers functional specificity in cardiomyocytes and cardiac responses
Mai, Q. N.; Lin, T.-Y.; Zhang, H.; Wilson, E.; Chien, H.-C.; Yee, S. W.; Giacomini, K. M.; Olgin, J. E.; Irannejad, R.
10.1101/2022.07.13.499965 — cell biology — Posted on 2022-07-14
2226 ModelArray: a memory-efficient R package for statistical analysis of fixel data
Zhao, C.; Tapera, T. M.; Bagautdinova, J.; Bourque, J.; Covitz, S.; Gur, R. E.; Gur, R. C.; Larsen, B.; Mehta, K.; Meisler, S. L.; Murtha, K.; Muschelli, J.; Roalf, D. R.; Sydnor, V. J.; Valcarcel, A. M.; Shinohara, R. T.; Cieslak, M.; Satterthwaite, T. D.
10.1101/2022.07.12.499631 — neuroscience — Posted on 2022-07-14
2228 Brassinosteroids signaling component SlBZR1 promotes fruit ripening in tomato
Meng, F.; Liu, H.; Hu, S.; Jia, C.; Zhang, M.; Li, S.; Li, Y.; Lin, J.; Jian, Y.; Wang, M.; Shao, Z.; Mao, Y.; Liu, L.; Wang, Q.
10.1101/2022.07.11.499596 — plant biology — Posted on 2022-07-14
2231 Single-nucleus RNA-seq reveals disrupted cell maturation by chorioamnionitis in the preterm cerebellum of nonhuman primates
Newman, J.; Tong, X.; Tan, A.; Nunes de Paiva, V.; Presicce, P. F.; Kannan, P. S.; Williams, K.; Damianos, A.; Tamase Newsam, M.; Benny, M.; Wu, S.; Young, K. C.; Miller, L.; Kallapur, S.; Chougnet, C. A.; Jobe, A. H.; Brambilla, R.; Schmidt, A. F.
10.1101/2022.07.12.499720 — neuroscience — Posted on 2022-07-14
2233 Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons
Petroccione, M.; D'Brant, L.; Affinnih, N.; Wehrle, P.; Todd, G.; Zahid, S.; Chesbro, H.; Tschang, I.; Scimemi, A.
10.1101/2022.07.12.499771 — neuroscience — Posted on 2022-07-14
2235 Neural Distinctiveness and Reinstatement of Hippocampal Representations Support Unitization for Associations
Ricupero, S.; Carpenter, C. M.; Steinkrauss, A. C.; Gerver, C. R.; Chamberlain, J. D.; Monkman, R. G.; Overman, A. A.; Dennis, N. A.
10.1101/2022.07.13.497755 — neuroscience — Posted on 2022-07-14
2240 Brassinosteroids signaling component SlBZR1 promotes fruit ripening in tomato
Meng, F.; Liu, H.; Hu, S.; Jia, C.; Zhang, M.; Li, S.; Li, Y.; Lin, J.; Jian, Y.; Wang, M.; Shao, Z.; Mao, Y.; Liu, L.; Wang, Q.
10.1101/2022.07.11.499596 — plant biology — Posted on 2022-07-14
2244 Structural and functional analysis of natural capsid variants reveals sialic-acid independent entry of BK polyomavirus
Sorin, M.; Di Maio, A.; Silva, L. M.; Ebert, D.; Delannoy, C.; Nguyen, N.-K.; Guerardel, Y.; Chai, W.; Halary, F.; Renaudin-Autain, K.; Liu, Y.; Bressollette-Bodin, C.; Stehle, T.; McILROY, D.
10.1101/2022.07.13.499703 — microbiology — Posted on 2022-07-14
2245 A metagenomic investigation of spatial and temporal changes in sewage microbiomes across a university campus
Fierer, N.; Holland-Moritz, H.; Alexiev, A.; Batther, H.; Dragone, N.; Friar, L.; Gebert, M. J.; Gering, S.; Henley, J. B.; Jech, S.; Kibby, E. M.; Melie, T.; Patterson, W.; Peterson, E.; Schutz, K.; Stallard-Olivera, E.; Sterrett, J.; Walsh, C. M.; Mansfeldt, C.
10.1101/2022.07.13.499996 — microbiology — Posted on 2022-07-14
2246 Monocyte-derived peritoneal macrophages protect C57BL/6 mice against surgery-induced adhesions
Sahputra, R.; Dejyong, K.; Woolf, A.; Mack, M.; Allen, J. E.; Ruckerl, D.; Herrick, S.
10.1101/2022.07.12.499772 — immunology — Posted on 2022-07-14
2247 Single-cell CD8+ dynamics in PLWH uncover the depletion of TIGIT+ memory HIV-1-specific cells during long-term ART
Blanch-Lombarte, O.; Ouchi, D.; Jimenez-Moyano, E.; Carabelli, J.; Marin, M. A.; Penya, R.; Pelletier, A.; Talla, A.; Sharma, A.; Dalmau, J.; Santos, J. R.; Sekaly, R.-P. A.; Clotet, B.; Prado, J. G.
10.1101/2022.07.13.499924 — immunology — Posted on 2022-07-14
2249 Structural basis of organic cation transporter-3 inhibition
Khanppnavar, B.; Maier, J.; Herborg, F.; Gradisch, R.; Lazzarin, E.; Luethi, D.; Yang, J.-W.; Qi, C.; Holy, M.; Jaentsch, K.; Kudlacek, O.; Schicker, K.; Werge, T.; Gether, U.; Stockner, T.; Korkhov, V.; Sitte, H. H.
10.1101/2022.07.14.499921 — pharmacology and toxicology — Posted on 2022-07-14
2252 Multipartite super-enhancers function in an orientation-dependent manner
Kassouf, M. T.; Francis, H. S.; Gosden, M.; Suciu, M. C.; Downes, D. J.; Harrold, C.; Larke, M.; Oudelaar, M.; Cornell, L.; Blayney, J.; Telenius, J.; Xella, B.; Shen, Y.; Sousos, N.; Sharpe, J. A.; Sloane-Stanley, J.; Smith, A.; Babbs, C.; Hughes, J. R.; Higgs, D. R.
10.1101/2022.07.14.499999 — molecular biology — Posted on 2022-07-14
2253 Single cell transcriptomic profiling of tauopathy in a novel 3D neuron-astrocyte coculture model
Rickner, H. D.; Jiang, L.; Hong, R.; O'Neill, N. K.; Mojica, C. A.; Synder, B. J.; Zhang, L.; Shaw, D.; Medalla, M.; Wolozin, B.; Cheng, C. S.
10.1101/2022.05.03.490513 — neuroscience — Posted on 2022-07-14
2259 Nationwide genomic biobank in Mexico unravels demographic history and complex trait architecture from 6,057 individuals
Sohail, M.; Chong, A. Y.; Quinto-Cortes, C. D.; Palma-Martinez, M. J.; Ragsdale, A.; Medina-Munoz, S. G.; Barberena-Jonas, C.; Delgado-Sanchez, G.; Cruz-Hervert, L. P.; Ferreyra-Reyes, L.; Ferreira-Guerrero, E.; Mongua-Rodriguez, N.; Jimenez-Kaufmann, A.; Moreno-Macias, H.; Aguilar-Salinas, C. A.; Auckland, K.; Cortes, A.; Acuna-Alonzo, V.; Ioannidis, A. G.; Gignoux, C. R.; Wojcik, G. L.; Fernandez-Valverde, S. L.; Hill, A. V. S.; Tusie-Luna, M. T.; Mentzer, A. J.; Novembre, J.; Garcia-Garcia, L.; Moreno-Estrada, A.
10.1101/2022.07.11.499652 — genomics — Posted on 2022-07-14
2260 ALLOPURINOL BLOCKS THE AORTIC ANEURYSM IN A MOUSE MODEL OF MARFAN SYNDROME VIA REDUCING AORTIC OXIDATIVE STRESS
Rodriguez-Rovira, I.; Arce, C.; Rycke, K. d.; Perez, B.; Carretereo, A.; Arbones, M.; Teixido-Tura, G.; Gomez-Cabrera, M. C.; Campuzano, V.; Jimenez-Altayo, F.; Egea, G.
10.1101/2021.10.13.464182 — pathology — Posted on 2022-07-14
2261 Macrophage-derived VEGF-C decreases hematogenous metastatic dissemination by normalizing the tumor vasculature
Ferreira, S. d. S.; Wallmann, T.; Kerzel, T.; Wallerius, M.; Bartish, M.; Landwehr, L. S.; Pan, Y.; Agardy, D. A.; Bergh, J.; Hartman, J.; Squadrito, M. L.; Rolny, C.
10.1101/2022.01.26.468593 — cancer biology — Posted on 2022-07-14
2262 Placental mammal derived microRNAs alter pathways in the endometrial epithelia important for endometrial function.
Hume, L.; Edge, J. C.; Tinning, H.; Wang, D.; Taylor, A. S.; Ovchinnikov, V.; Geijer-Simpson, A.; Vrljicak, P.; Brosens, J.; Lucas, E. S.; Simson, N. A. B.; Shillito, J.; Forbes, K.; O'Connell, M. J.; Forde, N.
10.1101/2022.04.23.489270 — cell biology — Posted on 2022-07-14
2263 Helical metaphase chromatid coiling is conserved
Kubalova, I.; Camara, A. S.; Capal, P.; Beseda, T.; Rouillard, J.-M.; Krause, G. M.; Toegelova, H.; Himmelbach, A.; Stein, N.; Houben, A.; Dolezel, J.; Mascher, M.; Simkova, H.; Schubert, V.
10.1101/2021.09.16.460607 — cell biology — Posted on 2022-07-14
2264 Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii
Wang, W.; Dweck, H. K. M.; Talross, G. J. S.; Zaidi, A.; Gendron, J. M.; Carlson, J. R.
10.1101/2022.07.13.499915 — neuroscience — Posted on 2022-07-14
2265 A Sterol-PI(4)P exchanger controls the Tel1/ATM axis of the DNA Damage Response
Ovejero, S.; Kumanski, S.; Soulet, C.; Azarli, J.; Pardo, B.; Santt, O.; Constantinou, A.; Pasero, P.; Moriel-Carretero, M.
10.1101/2022.07.13.499867 — cell biology — Posted on 2022-07-14
2266 Comprehensive characterization of toxins defines progression and stages in a non-human primate model of inhalation anthrax
Boyer, A. E.; Gallegos Candela, M.; Lins, R. C.; Solano, M. I.; Woolfitt, A. R.; Lee, J.; Sanford, D. C.; Knostman, K.; Quinn, C. P.; Hoffmaster, A. R.; Pirkle, J. L.; Barr, J. R.
10.1101/2022.07.13.499850 — microbiology — Posted on 2022-07-14
2267 Phosphorylation and ubiquitination independent endocytosis of BRI1
Russinova, E.; Alves Neubus Claus, L.; Liu, D.; Hohmann, U.; Vukasinovic, N.; Pleskot, R.; Liu, J.; Schiffner, A.; Jaillais, Y.; Wu, G.; Wolf, S.; Van Damme, D.; Hothorn, M.
10.1101/2022.07.11.499622 — plant biology — Posted on 2022-07-14
2268 Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespan
Tong, R.; Li, R.; Zhao, Y.; Luo, L.; Zhong, J.; Li, Z.; Wei, L.; Chen, Y.; Shi, J.; Gao, Y.; Sun, M.; Wang, Y.; Lyu, Y.; Yuan, A.; Sun, L.; Guo, Y.; Wang, H.; Chen, H.; Chen, L.; Li, B.; Lin, W.; Wang, F.; Wang, L.; Pu, J.
10.1101/2022.07.11.498621 — immunology — Posted on 2022-07-14
2269 Binding of His-tagged fluorophores to lipid bilayers and giant vesicles
Pramanik, S.; Steinkuehler, J.; Dimova, R.; Spatz, J.; Lipowsky, R.
10.1101/2022.02.01.478643 — biophysics — Posted on 2022-07-14
2270 An Open Microfluidic Coculture Model of Fibroblasts and Eosinophils to Investigate Mechanisms of Airway Inflammation
Zeng, Y.; Su, X.; Takezawa, M. G.; Fichtinger, P. S.; Lee, U. N.; Pippin, J. W.; Shankland, S. J.; Lim, F. Y.; Denlinger, L. C.; Jarjour, N. N.; Mathur, S. K.; Sandbo, N.; Berthier, E.; Esnault, S.; Bernau, K.; Theberge, A. B.
10.1101/2022.07.11.499658 — cell biology — Posted on 2022-07-14
2272 Identification of a distinct ductal subpopulation with self-renewal and differentiation potential from the adult murine pancreas
Tremblay, J. R.; Ortiz, J. A.; Quijano, J. C.; Zook, H.; LeBon, J. M.; Li, W.; Jou, K.; Tsark, W.; Mann, J. R.; Kozlowski, M.; Tirrell, D. A.; Esni, F.; Engle, D. D.; Riggs, A. D.; Ku, H. T.
10.1101/2022.07.12.499653 — cell biology — Posted on 2022-07-13
2273 SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA
Maharana, S.; Kretschmer, S.; Hunger, S.; Yan, X.; Kuster, D.; Traikov, S.; Zillinger, T.; Chappidi, N.; Lucas, N.; Maser, K. I.; Maatz, H.; Rapp, A.; Marchand, V.; Iyer, V.; Chhabra, A.; Chang, Y.-T.; Motorin, Y.; Hubner, N.; Hartmann, G.; Hyman, A. A.; Alberti, S.; Lee-Kirsch, M. A.
10.1101/2022.07.12.499661 — immunology — Posted on 2022-07-13
2275 High-throughput feedback-enabled optogenetic stimulation and spectroscopy in microwell plates
Datta, S.; Benman, W.; Gonzalez-Martinez, D.; Lee, G.; Hooper, J.; Qian, G.; Leavitt, G.; Salloum, L.; Ho, G.; Mhatre, S.; Magaraci, M. S.; Patterson, M.; Mannickarottu, S. G.; Malani, S.; Avalos, J. L.; Chow, B. Y.; Bugaj, L. J.
10.1101/2022.07.13.499906 — synthetic biology — Posted on 2022-07-13
2276 High-throughput Identification of Novel Heat Tolerance Genes via Genome-wide Pooled Mutant Screens in the Model Green Alga Chlamydomonas reinhardtii
Mattoon, E. M.; McHargue, W.; Bailey, C. E.; Zhang, N.; Chen, C.; Eckhardt, J.; Daum, C. G.; Zane, M.; Pennacchio, C.; Schmutz, J.; O'Malley, R. C.; Cheng, J.; Zhang, R.
10.1101/2022.07.13.499508 — plant biology — Posted on 2022-07-13
2279 Optimizing the Cell Painting assay for image-based profiling
Cimini, B. A.; Chandrasekaran, S. N.; Kost-Alimova, M.; Miller, L.; Goodale, A.; Fritchman, B.; Byrne, P.; Garg, S.; Jamali, N.; Logan, D. J.; Concannon, J. B.; Lardeau, C.-H.; Mouchet, E.; Singh, S.; Abbasi, H. S.; Aspesi, P.; Boyd, J. D.; Gilbert, T.; Gnutt, D.; Hariharan, S.; Hernandez, D.; Hormel, G.; Juhani, K.; Melanson, M.; Mervin, L.; Monteverde, T.; Pilling, J. E.; Skepner, A.; Swalley, S. E.; Vrcic, A.; Weisbart, E.; Williams, G.; Yu, S.; Zapiec, B.; Carpenter, A. E.
10.1101/2022.07.13.499171 — bioinformatics — Posted on 2022-07-13
2280 Structural basis of interdomain communication in PPARγ
Mosure, S. A.; Munoz-Tello, P.; Kuo, K.-T.; MacTavish, B.; Yu, X.; Scholl, D.; Williams, C. C.; Strutzenberg, T. S.; Bass, J.; Brust, R.; Deniz, A. A.; Griffin, P. R.; Kojetin, D. J.
10.1101/2022.07.13.499031 — biochemistry — Posted on 2022-07-13
2281 Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors
Replogle, J. M.; Bonnar, J. L.; Pogson, A. N.; Liem, C. R.; Maier, N. K.; Ding, Y.; Russell, B. J.; Wang, X.; Leng, K.; Guna, A.; Norman, T. M.; Pak, R. A.; Ramos, D. M.; Ward, M. E.; Gilbert, L. A.; Kampmann, M.; Weissman, J. S.; Jost, M.
10.1101/2022.07.13.499814 — genomics — Posted on 2022-07-13
2284 Genomic and phenotypic trait variation of the opportunistic human pathogen Aspergillus flavus and its non-pathogenic close relatives
Hatmaker, E. A.; Rangel-Grimaldo, M.; Raja, H. A.; Knowles, S. L.; Pourhadi, H.; Fuller, K.; Adams, E. M.; Lightfoot, J. D.; Bastos, R.; Goldman, G. H.; Oberlies, N. H.; Rokas, A.
10.1101/2022.07.12.499845 — evolutionary biology — Posted on 2022-07-13
2288 A CDKB/KRP/FB3 cell cycle core complex functions in rice gametes and zygotes
Xu, H.; Bartley, L.; Libault, M.; Sundaresan, V.; Fu, H.; Russell, S. D.
10.1101/2022.07.12.499798 — cell biology — Posted on 2022-07-13
2289 Development of a Xenopus-based assay for high-throughput evaluation of mucociliary flow
Antoniades, I.; Koulle, A.; Chatzifrangkeskou, M.; Konstantinou, T.; Skourides, P. A.
10.1101/2022.07.12.499724 — cell biology — Posted on 2022-07-13
2292 GPCR-dependent spatiotemporal cAMP generation confers functional specificity in cardiomyocytes and cardiac responses
Irannejad, R.; Mai, Q. N.; Lin, T.-Y.; Zhang, H.; Wilson, E.; Chien, H.-C.; Yee, S. W.; Giacomini, K. M.; Olgin, J. E.
10.1101/2022.07.13.499965 — cell biology — Posted on 2022-07-13
2293 Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function
gao, h.; Zhong, y.; Zhou, l.; Lin, s.; Hou, x.; Ding, z.; Li, y.; Yao, q.; Cao, h.; Zou, x.; Chen, D.; Bai, x.; Xiao, G.
10.1101/2022.07.13.499909 — cell biology — Posted on 2022-07-13
2295 Comparing the accuracy and efficiency of third generation DNA barcode sequencing: Oxford Nanopore Technologies versus Pacific Biosciences
Cuber, P.; Chooneea, D.; Geeves, C.; Salatino, S.; Creedy, T.; Griffin, C.; Sivess, L.; Barnes, I.; Price, B.; Misra, R.
10.1101/2022.07.13.499863 — molecular biology — Posted on 2022-07-13
2297 MukBEF-dependent chromosomal organization in widened Escherichia coli
Japaridze, A.; van Wee, R.; Gogou, C.; Kerssemakers, J. W. J.; Dekker, C.
10.1101/2022.07.13.499882 — microbiology — Posted on 2022-07-13
2299 Cell specialization in cyanobacterial biofilm development revealed by expression of a cell-surface and extracellular matrix protein
Frenkel, A.; Zecharia, E.; Gomez-Perez, D.; Yegorov, Y.; Sendersky, E.; Jacobs, A.; Benichou, J.; Stierhof, Y.-D.; Parnasa, R.; Golden, S. S.; Kemen, E.; Schwarz, R.
10.1101/2022.07.13.498973 — microbiology — Posted on 2022-07-13
2300 Genetic and physiological insights into the diazotrophic activity of a non-cyanobacterial marine diazotroph
Joublin-Delavat, A.; Touahri, K.; Morot, A.; Rodrigues, S.; Jesus, B.; Trigodet, F.; Delavat, F.
10.1101/2022.07.13.499682 — microbiology — Posted on 2022-07-13
2301 The influence of extrachromosomal elements in the anthrax "cross-over" strain Bacillus cereus G9241
Taylor-Joyce, G.; Manoharan, S.; Brooker, T.; Hernandez-Rodriguez, C. S.; Baillie, L.; Oyston, P.; Hapeshi, A.; Waterfield, N. R.
10.1101/2022.07.13.499895 — microbiology — Posted on 2022-07-13
2302 Mutational spectra analysis reveals bacterial niche and transmission routes
Ruis, C.; Weimann, A.; Tonkin-Hill, G.; Pandurangan, A. P.; MATUSZEWSKA, M.; Murray, G. G. R.; Levesque, R. C.; Blundell, T. L.; Floto, R. A.; Parkhill, J.
10.1101/2022.07.13.499881 — microbiology — Posted on 2022-07-13
2303 Ionic control of porin permeability in bacteria.
Cano Muniz, S.; Hagting, A.; Evans, I.; Alsulami, A.; Summers, D. K.; Blundell, T.; Floto, R. A.
10.1101/2022.07.13.499887 — microbiology — Posted on 2022-07-13
2306 Correction of susceptibility distortion in EPI: a semi-supervised approach with deep learning.
Legouhy, A.; Graham, M.; Guerreri, M.; Stee, W.; Villemonteix, T.; Peigneux, P.; Zhang, H.
10.1101/2022.07.12.499591 — neuroscience — Posted on 2022-07-13
2307 Spatiotemporal properties of glutamate input support direction selectivity in the dendrites of retinal starburst amacrine cells
Srivastava, P.; deRosenroll, G.; Murphy-Baum, B. L.; Michaels, T.; Matsumoto, A.; Yonehara, K.; Awatramani, G. B.
10.1101/2022.07.12.499686 — neuroscience — Posted on 2022-07-13
2308 A branching model of cell fate decisions in the enteric nervous system
Laddach, A. C.; Chng, S. H.; Lasrado, R.; Progatzky, F.; Shapiro, M.; Artemov, A.; Castaneda, M. S.; Erickson, A.; Bon-Frauches, A. C.; Kleinjung, J.; Boeing, S.; Ultanir, S.; Adameyko, I.; Pachnis, V.
10.1101/2022.07.12.499640 — neuroscience — Posted on 2022-07-13
2311 Direct attenuation of Arabidopsis ERECTA signaling by a pair of U-box E3 ligases
Chen, L.; Cochran, A. M.; Waite, J.; Shirasu, K.; Bemis, S. M.; Torii, K. U.
10.1101/2022.07.11.499617 — plant biology — Posted on 2022-07-13
2313 Biomechanical Investigation of Ancient Maya Warfare at Mayapan, Yucatan, Mexico
Dorranian, D.; Serafin, S.; Peraza Lope, C.; Uc Gonzalez, E.; Russell, B.; Murphy, E.; Wilson, L. A. B.
10.1101/2022.07.11.499503 — paleontology — Posted on 2022-07-13
2318 Single-nucleus ATAC-seq elucidates major modules of gene regulation in the development of non-alcoholic fatty liver disease
Takeuchi, F.; Liang, Y.-Q.; Shimizu-Furusawa, H.; Isono, M.; Ang, M. Y.; Mori, K.; Mori, T.; Kakazu, E.; Yoshio, S.; Kato, N.
10.1101/2022.07.12.499681 — genomics — Posted on 2022-07-13
2321 IDENTIFICATION OF A NOVEL MECHANISM FOR LFA-1 ORGANIZATION DURING NK CYTOLYTIC RESPONSE
Pariani, A. P.; Almada, E.; Hidalgo, F.; Borini-Etichetti, C.; Vena, R.; Marin, L.; Favre, C.; Goldenring, J. R.; Larocca, M. C.
10.1101/2020.10.27.357970 — cell biology — Posted on 2022-07-13
2329 Brassinosteroids signaling component SlBZR1 promotes fruit ripening in tomato
Meng, F.; Liu, H.; Hu, S.; Jia, C.; Zhang, M.; Li, S.; Li, Y.; Lin, J.; Jian, Y.; Wang, M.; Shao, Z.; Mao, Y.; Liu, L.; Wang, Q.
10.1101/2022.07.11.499596 — plant biology — Posted on 2022-07-13
2330 KDM6A loss sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition
Boila, L. D.; Ghosh, S.; Bandyopadhyay, S. K.; Jin, L.; Murison, A.; Zeng, A. G. X.; Shaikh, W.; Bhowmik, S.; Muddineni, S. S. N. A.; Biswas, M.; Sinha, S.; Chatterjee, S. S.; Mbong, N.; Gan, O. I.; Bose, A.; Chakraborty, S.; Arruda, A.; Kennedy, J. A.; Mitchell, A.; Lechman, E. R.; Banerjee, D.; Milyavsky, M.; Minden, M. D.; Dick, J. E.; Sengupta, A.
10.1101/2022.07.12.498585 — cancer biology — Posted on 2022-07-13
2331 Identification of leukemia-associated immunophenotypes by database-guided flow cytometry provides a highly sensitive and reproduciblestrategy for the study of measurable residual disease in acutemyeloblastic leukemia
Pinero, P.; Morillas, M.; Gutierrez, N.; Barragan, E.; Such, E.; Brena, J.; Gil, C.; Garcia, C.; Botella, C.; Gonzalez-Navajas, J. M.; Zapater, P.; Montesinos, P.; Sempere, A.; Tarin, F.
10.1101/2022.07.12.499672 — cancer biology — Posted on 2022-07-13
2332 SMALL MOLECULE CLPP AGONISTS INDUCE SENESCENCE AND ALTER TRAIL-MEDIATED APOPTOTIC RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER CELLS
Aponte-Collazo, L. J.; Fennell, E. M. J.; East, M. P.; Gilbert, T. S. K.; Graves, P. R.; Ashamalla, H.; Iwanowicz, E.; Greer, Y. E.; Lipkowitz, S.; Graves, L. M.
10.1101/2022.07.11.499620 — cancer biology — Posted on 2022-07-13
2333 Infiltration of Tumor Spheroids by Activated Immune Cells
Mukherjee, M.; Chepizhko, O.; Lionetti, M. C.; Zapperi, S.; La Porta, C. A. M.; Levine, H.
10.1101/2022.07.11.499636 — cancer biology — Posted on 2022-07-13
2339 Triterpenoid production with a minimally engineered Saccharomyces cerevisiae chassis
Ebert, B. E.; Guo, H.; Jacobsen, S. A. B.; Walter, K.; Czarnotta, E.; Lewandowski, A.; Maury, J.; Polakowski, T.; Knuf, C.; Lang, C.; Foerster, J.; Blank, L. M.
10.1101/2022.07.11.499565 — bioengineering — Posted on 2022-07-13
2342 Nationwide genomic biobank in Mexico unravels demographic history and complex trait architecture from 6,057 individuals
Sohail, M.; Chong, A. Y.; Quinto-Cortes, C. D.; Palma-Martinez, M. J.; Ragsdale, A.; Medina-Munoz, S. G.; Barberena-Jonas, C.; Delgado-Sanchez, G.; Cruz-Hervert, L. P.; Ferreyra-Reyes, L.; Ferreira-Guerrero, E.; Mongua-Rodriguez, N.; Jimenez-Kaufmann, A.; Moreno-Macias, H.; Aguilar-Salinas, C. A.; Auckland, K.; Cortes, A.; Acuna-Alonzo, V.; Ioannidis, A. G.; Gignoux, C. R.; Wojcik, G. L.; Fernandez-Valverde, S. L.; Hill, A. V. S.; Tusie-Luna, M. T.; Mentzer, A. J.; Novembre, J.; Garcia-Garcia, L.; Moreno-Estrada, A.
10.1101/2022.07.11.499652 — genomics — Posted on 2022-07-13
2347 Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespan
Tong, R.; Li, R.; Zhao, Y.; Luo, L.; Zhong, J.; Li, Z.; Wei, L.; Chen, Y.; Shi, J.; Gao, Y.; Sun, M.; Wang, Y.; Lyu, Y.; Yuan, A.; Sun, L.; Guo, Y.; Wang, H.; Chen, H.; Chen, L.; Li, B.; Lin, W.; Wang, F.; Wang, L.; Pu, J.
10.1101/2022.07.11.498621 — immunology — Posted on 2022-07-13
2348 Yttrium-iron garnet magnetometer in MEG: Advance towards multi-channel arrays
Skidchenko, E.; Butorina, A.; Ostras, M.; Vetoshko, P.; Kuzmichev, A.; Yavich, N.; Malovichko, M.; Koshev, N.
10.1101/2022.07.11.499607 — neuroscience — Posted on 2022-07-13
2349 Mapping Pharmacologically-induced Functional Reorganisation onto the Brain's Neurotransmitter Landscape
Luppi, A. I.; Hansen, J. Y.; Adapa, R.; Carhart-Harris, R. L.; Roseman, L.; Golkowski, D.; Ranft, A.; Ilg, R.; Jordan, D.; Peattie, A. R. D.; Manktelow, A. E.; de Araujo, D. B.; Sensi, S. L.; Owen, A. M.; Naci, L.; Menon, D. K.; Misic, B.; Stamatakis, E. A.
10.1101/2022.07.12.499688 — neuroscience — Posted on 2022-07-13
2353 Machine learning reveals conserved chromatin patterns determining meiotic recombination sites in plants
Wang, M.; Shilo, S.; Zhou, A.; Zelkowski, M.; Olson, M. A.; Azuri, I.; Shoshani-Hechel, N.; Melamed-Bessudo, C.; Marand, A. P.; Jiang, J.; Schnable, J. C.; Underwood, C. J.; Henderson, I. R.; Sun, Q.; Pillardy, J.; Kianian, P. M. A.; Kianian, S. F.; Chen, C.; Levy, A. A.; Pawlowski, W. P.
10.1101/2022.07.11.499557 — plant biology — Posted on 2022-07-13
2355 AlphaViz: Visualization and validation of critical proteomics data directly at the raw data level
Voytik, E.; Skowronek, P.; Zeng, W.-F.; Tanzer, M. C.; Brunner, A.-D.; Thielert, M.; Strauss, M. T.; Willems, S.; Mann, M.
10.1101/2022.07.12.499676 — bioinformatics — Posted on 2022-07-13
2357 The spatial distribution and temporal trends of livestock damages caused by wolves in Europe
Singer, L.; Wietlisbach, X.; Hickisch, R.; Schoell, E. M.; Van den Broek, A.; Desalme, M.; Driesen, K.; Lyly, M.; Marucco, F.; Kutal, M.; Pagon, N.; Papp, C. R.; Milioni, P.; Uzdras, R.; Zihmanis, I.; Zimmermann, F.; Marsden, K.; Hackländer, K.; Lopez-Bao, J. V.; Klenzendorf, S.; Wegmann, D.
10.1101/2022.07.12.499715 — ecology — Posted on 2022-07-13
2358 Bacterial pattern recognition in C. elegans by a nuclear hormone receptor
Peterson, N. D.; Tse, S. Y.; Huang, Q. J.; Schiffer, C. A.; Pukkila-Worley, R.
10.1101/2022.07.12.499718 — immunology — Posted on 2022-07-13
2359 Molecular Neurobiology of Loss
Smail, M. A.; Smith, B. L.; Shukla, R.; Alganem, K.; Eby, H. M.; Bollinger, J. L.; Parikh, R. K.; Chambers, J. B.; Reigle, J. K.; Moloney, R. D.; Nawreen, N.; Wohleb, E. S.; Pantazopoulos, H.; McCullumsmith, R. E.; Herman, J. P.
10.1101/2022.07.13.499899 — neuroscience — Posted on 2022-07-13
2361 Intense light unleashes male courtship behaviorin wild-type Drosophila
Ueda, A.; Berg, A.; Khan, T.; Li, S.; Cramer, E.; Ruzicka, M.; Wu, C.-F.; Iyengar, A.
10.1101/2022.07.12.499756 — neuroscience — Posted on 2022-07-13
2362 OptoPi: An open source flexible platform for the analysis of small animal behaviour
Cano-Ferrer, X.; Roberts, R. J. V.; French, A. S.; de Folter, J.; Gong, H.; Nightingale, L.; Strange, A.; Imbert, A.; Prieto-Godino, L. L.
10.1101/2022.07.12.499786 — neuroscience — Posted on 2022-07-13
2363 Structural and functional landscape of α-synuclein fibril conformations amplified from cerebrospinal fluid
Sokratian, A.; Zhou, Y.; Xu, E.; Viverette, E.; Dillard, L.; Yuan, Y.; Li, J.; Matarangas, A.; Bouvette, J.; Borgnia, M. J.; Bartesaghi, A.; West, A.
10.1101/2022.07.13.499896 — neuroscience — Posted on 2022-07-13
2367 Newborn chicks prefer stimuli that move against gravity
Bliss, L.; Vasas, V.; Freeland, L.; Roach, R.; Ferre, E. R.; Versace, E.
10.1101/2022.07.13.499929 — animal behavior and cognition — Posted on 2022-07-13
2368 Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart
Read, D. F.; Daza, R. M.; Booth, G. T.; Jackson, D. L.; Gladden, R. G.; Srivatsan, S. R.; Ewing, B.; Franks, J. M.; Spurrell, C. H.; Gomes, A. R.; O'Day, D.; Gogate, A. A.; Martin, B. K.; Starita, L. M.; Lin, Y.; Shendure, J.; Lin, S.; Trapnell, C.
10.1101/2022.07.12.496461 — genomics — Posted on 2022-07-13
2369 Molecular and Anatomical Characterization of Parabrachial Neurons and Their Axonal Projections
Pauli, J. L.; Chen, J. Y.; Basiri, M. L.; Park, S.; Carter, M. E.; Sanz, E.; McKnight, G. S.; Stuber, G. D.; Palmiter, R. D.
10.1101/2022.07.13.499944 — neuroscience — Posted on 2022-07-13
2370 Circadian regulation of hippocampal function is disrupted with chronic corticosteroid treatment
Birnie, M. T.; Claydon, M. D. B.; Flynn, B. P.; Yoshimura, M.; Kershaw, Y. M.; Demski-Allen, R. C. R.; Barker, G. R. I.; Warburton, C. E.; Bortolotto, Z. A.; Lightman, S. L.; Conway-Campbell, B. L.
10.1101/2022.07.12.499774 — neuroscience — Posted on 2022-07-13
2372 NudC regulated Lis1 stability is essential for maintenance of dynamic microtubule ends in the axon terminal
Kawano, D.; Pinter, K.; Chlebowski, M.; Petralia, R. S.; Wang, Y.-X.; Nechiporuk, A.; Drerup, C.
10.1101/2022.07.12.499810 — neuroscience — Posted on 2022-07-13
2377 Stable Potassium Isotopes (41K/39K) Track Transcellular and Paracellular Potassium Transport in Biological Systems
Higgins, J. A.; Santiago-Ramos, D.; Gili, S.; Spetea, C.; Kanoski, S.; Ha, D.; McDonough, A. A.; Youn, J. H.
10.1101/2022.01.31.478485 — physiology — Posted on 2022-07-13
2382 CRISPR/Cas9 screen for genome-wide interrogation of essential MYC binding sites in cancer cells
Kazimierska, M.; Podralska, M.; Zurawek, M.; Wozniak, T.; Kasprzyk, M. E.; Sura, W.; Losiewski, W.; Ziolkowska-Suchanek, I.; Kluiver, J. L.; van den Berg, A.; Rozwadowska, N.; Dzikiewicz-Krawczyk, A.
10.1101/2021.08.02.454734 — molecular biology — Posted on 2022-07-13
2383 Single cell transcriptomic profiling of tauopathy in a novel 3D neuron-astrocyte coculture model
Rickner, H. D.; Jiang, L.; Hong, R.; O'Neill, N. K.; Mojica, C. A.; Synder, B. J.; Zhang, L.; Shaw, D.; Medalla, M.; Wolozin, B.; Cheng, C. S.
10.1101/2022.05.03.490513 — neuroscience — Posted on 2022-07-13
2385 Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins
Martin, E. A.; Michel, J. C.; Kissinger, J. S.; Echeverry, F. A.; Lin, Y.-P.; O'Brien, J.; Pereda, A. E.; Miller, A. C.
10.1101/2022.02.07.479472 — neuroscience — Posted on 2022-07-13
2386 Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+ myeloid cells into the tumor microenvironment in a redundant manner
Takacs, G. P.; Kreiger, C. J.; Luo, D.; Tian, G.; Garcia, J. S.; Deleyrolle, L. P.; Mitchell, D. A.; Harrison, J. K.
10.1101/2022.07.08.499173 — cancer biology — Posted on 2022-07-13
2388 HMMploidy: inference of ploidy levels from short-read sequencing data
Soraggi, S.; Rhodes, J.; Altinkaya, I.; Tarrant, O.; Balloux, F.; Fisher, M. C.; Fumagalli, M.
10.1101/2021.06.29.450340 — bioinformatics — Posted on 2022-07-13
2392 Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2
Seibert, B.; Caceres, C. J.; Carnaccini, S.; Cardenas-Garcia, S.; Gay, L. C.; Ortiz, L.; Geiger, G.; de Souza Rajao, D. S.; Ottesen, E.; Perez, D. R.
10.1101/2022.07.13.499851 — microbiology — Posted on 2022-07-13
2394 Inducible Bronchus-Associated Lymphoid Tissue in SARS-CoV-2 Infected Rhesus Macaques
Ma, Z.-M.; Olstad, K. J.; Van Rompay, K. K. A.; Iyer, S. S.; Miller, C. J.; Reader, J. R.
10.1101/2022.07.12.499813 — pathology — Posted on 2022-07-13
2396 Accurate protein stability predictions from homology models
Valanciute, A.; Nygaard, L.; Zschach, H.; Jepsen, M. M.; Lindorff-Larsen, K.; Stein, A.
10.1101/2022.07.12.499700 — biophysics — Posted on 2022-07-13
2397 A proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition
Barkova, A.; Adhya, I.; Conesa, C.; Asif-Laidin, A.; BONNET, A.; Rabut, E.; Chagneau, c.; Lesage, P.; Acker, J.
10.1101/2022.07.13.499880 — biochemistry — Posted on 2022-07-13
2400 Optical Control of Translation with a Puromycin-Photoswitch
Ko, T.; Martins, M.; Alapin, J. M.; Morstein, J.; Klann, E.; Trauner, D. H.
10.1101/2022.07.12.499823 — biochemistry — Posted on 2022-07-13
2401 In Vitro Evaluation and Mitigation of Niclosamide's Liabilities as a COVID-19 Treatment.
Wotring, J. W.; McCarty, S. M.; Shafiq, K.; Zhang, C. J.; Nguyen, T.; Meyer, S. R.; Fursmidt, R.; Mirabelli, C.; Clasby, M. C.; Wobus, C. E.; O'Meara, M. J.; Sexton, J. Z.
10.1101/2022.06.24.497526 — microbiology — Posted on 2022-07-13
2404 Effects of Long-Term Alcohol Consumption on Behavior in the P301S (Line PS19) Tauopathy Mouse Model
Catavero, C. M.; Marsh, A. E.; Downs, A. M.; Teklezghi, A. T.; Cohen, T. J.; McElligott, Z. A.
10.1101/2022.07.12.499737 — neuroscience — Posted on 2022-07-13
2407 Anion efflux mediates transduction in hair cells of zebrafish lateral line
Lunsford, E. T.; Bobkov, Y. V.; Ray, B. C.; Liao, J. C.; Strother, J. A.
10.1101/2022.07.11.499370 — neuroscience — Posted on 2022-07-13
2408 Mapping SARS-CoV-2 antigenic relationships and serological responses
Wilks, S. H.; Muhlemann, B.; Shen, X.; Tureli, S.; LeGresley, E. B.; Netzl, A.; Caniza, M. A.; Chacaltana-Huarcaya, J. N.; Corman, V. M.; Daniell, X.; Datto, M. B.; Dawood, F. S.; Denny, T. N.; Drosten, C.; Fouchier, R. A. M.; Garcia, P. J.; Halfmann, P. J.; Jassem, A.; Jeworowski, L. M.; Jones, T. C.; Kawaoka, Y.; Krammer, F.; McDanal, C.; Pajon, R.; Simon, V.; Stockwell, M.; Tang, H.; van Bakel, H.; Veguilla, V.; Webby, R.; Montefiori, D. C.; Smith, D. J.
10.1101/2022.01.28.477987 — immunology — Posted on 2022-07-13
2409 Large neutral amino acid levels tune perinatal neuronal excitability and survival
Knaus, L. S.; Basilico, B.; Malzl, D.; Gerykova Bujalkova, M.; Smogavec, M.; Schwarz, L. A.; Gorkiewicz, S.; Amberg, N.; Pauler, F.; Rülicke, T.; Menche, J.; Hippenmeyer, S.; Novarino, G.
10.1101/2022.07.12.499841 — neuroscience — Posted on 2022-07-13
2411 Template-free prediction of a new protein fold and oligomeric assembly by Alphafold2
Gulsevin, A.; Han, B.; Porta, J. C.; Mchaourab, H.; Meiler, J.; Kenworthy, A. K.
10.1101/2022.07.12.499809 — biophysics — Posted on 2022-07-13
2412 A novel lineage of the Capra genus discovered in the Taurus Mountains of Turkey using ancient genomics.
Daly, K. G.; Arbuckle, B. S.; Rossi, C.; Mattiangeli, V.; Lawlor, P. A.; Mashkour, M.; Sauer, E.; Lesur, J.; Atici, L.; Erek, C. M.; Bradley, D. G.
10.1101/2022.04.08.487619 — genomics — Posted on 2022-07-13
2413 RGG-motif proteins regulate mRNA translation upon genotoxic stress
Roy, R.; Mohanan, G.; Malka-Mahieu, H.; Biswas, A.; Labbe, C.; Vagner, S.; Rajyaguru, P. I.
10.1101/2022.07.12.499753 — cell biology — Posted on 2022-07-13
2414 Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation
Ren, X.; Nguyen, T. N.; Lam, W. K.; Buffalo, C. Z.; Lazarou, M.; Yokom, A. L.; Hurley, J. H.
10.1101/2022.07.12.499634 — cell biology — Posted on 2022-07-13
2415 Genotypic sex shapes maternal care in the African Pygmy mouse, Mus minutoides
Heitzmann, L. D.; Challe, M.; Perez, J.; Castell, L.; Galibert, E.; Martin, A.; Valjent, E.; Veyrunes, F.
10.1101/2022.04.05.487174 — evolutionary biology — Posted on 2022-07-13
2417 Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD
Abenza, J. F.; Rossetti, L.; Mouelhi, M.; Burgues, J.; Andreu, I.; Kennedy, K.; Roca-Cusachs, P.; Marco, S.; Garcia-Ojalvo, J.; Trepat, X.
10.1101/2022.02.04.478830 — cell biology — Posted on 2022-07-13
2418 Natural Variation in Diauxic Shift between Patagonian Saccharomyces eubayanus Strains
Molinet, J.; Eizaguirre, J. I.; Quintrel, P. A.; Bellora, N.; Villarroel, C. A.; Villarreal, P.; Benavides-Parra, J.; Nespolo, R. F.; Libkind, D.; Cubillos, F. A.
10.1101/2022.07.11.499665 — microbiology — Posted on 2022-07-13
2419 Enhanced mismatch negativity in harmonic compared to inharmonic sound sequences
Quiroga-Martinez, D. R.; Basinski, K.; Nasielski, J.; Tillmann, B.; Brattico, E.; Cholvy, F.; Fornoni, L.; Vuust, P.; Caclin, A.
10.1101/2021.10.15.464562 — neuroscience — Posted on 2022-07-13
2421 fMRIflows: a consortium of fully automatic univariate and multivariate fMRI processing pipelines
Notter, M. P.; Herholz, P.; Da Costa, S.; Gulban, O. F.; Isik, A. I.; Gaglianese, A.; Murray, M. M.
10.1101/2021.03.23.436650 — neuroscience — Posted on 2022-07-13
2424 Genome-Wide Association Study in a Rat Model of Temperament Identifies Multiple Loci for Exploratory Locomotion and Anxiety-Like Traits
Chitre, A. S.; Hebda-Bauer, E. K.; Blandino, P.; Bimschleger, H.; Nguyen, K.-M.; Maras, P.; Li, F.; Ozel, A. B.; Polesskaya, O.; Cheng, R.; Flagel, S. B.; Watson, S. J.; Li, J.; Akil, H.; Palmer, A. A.
10.1101/2022.07.12.499605 — genetics — Posted on 2022-07-13
2428 Extrafollicular responses are sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus
Voss, L. F.; Howarth, A. J.; Wittenborn, T. R.; Hummelgaard, S.; Juul-Madsen, K.; Kastberg, K. S.; Pedersen, M. K.; Jensen, L.; Papanastasiou, A. D.; Vorup-Jensen, T.; Weyer, K.; Degn, S. E.
10.1101/2022.03.04.482991 — immunology — Posted on 2022-07-13
2430 A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis
Wang, Y.; Zhu, D.; Ortiz-Velez, L. C.; Perry, J. L.; Pennington, M. W.; Hyser, J. M.; Britton, R. A.; Beeton, C.
10.1101/2022.07.12.499749 — synthetic biology — Posted on 2022-07-13
2431 Heterogeneity of RNA editing in mesothelioma and how RNA editing enzyme ADAR2 affects mesothelioma cell growth, response to chemotherapy and tumor microenvironment
Hariharan, A.; Qi, W.; Rehrauer, H.; Wu, L.; Ronner, M.; Wipplinger, M.; Kresoja-Rakic, J.; Sun, S.; Oton-Gonzales, L.; Sculco, M.; Serre-Beinier, V.; Meiller, C.; Blanquart, C.; Fonteneau, J.-F.; Vrugt, B.; Rueschoff, J. H.; Opitz, I.; JEAN, D.; de Perrot, M.; Felley-Bosco, E.
10.1101/2022.07.12.499727 — cancer biology — Posted on 2022-07-13
2432 propeller: testing for differences in cell type proportions in single cell data
Phipson, B.; Sim, C. B.; Porrello, E. R.; Hewitt, A. W.; Powell, J.; Oshlack, A.
10.1101/2021.11.28.470236 — bioinformatics — Posted on 2022-07-13
2434 A 2D Fragment-Assisted Protein Mimetic Approach to Rescue α-Synuclein Aggregation Mediated Early and Post-Disease Parkinsons Phenotypes
Kumar, S.; Stillman, N. H.; Joseph, J. A.; Ahmed, J.; Dohoney, R. A.; Ball, T. D.; Thomas, A. G.; Fitch, T. C.; Donnelly, C. M.
10.1101/2022.07.11.499659 — biochemistry — Posted on 2022-07-13
2436 Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease
Tay, K. Y.; Wu, K. X.; Chioh, F.; Autio, M. I.; Pek, N.; Chakrapani, N. B.; Tan, S. H.; Low, A.; Lian, M. M.; Chew, E. G. Y.; Lau, H. H.; Kao, S. L.; Teo, A.; Foo, J. N.; Foo, R.; Heng, C. K.; Chan, M.; Cheung, C.
10.1101/2022.07.12.499721 — molecular biology — Posted on 2022-07-13
2439 Genetically Corrected RAG2-SCID Human Hematopoietic Stem CellsRestore V(D)J-Recombinase and Rescue Lymphoid Deficiency
Pavel-Dinu, M.; Gardner, C. L.; Nakauchi, Y.; Kawai, T.; Delmonte, O. M.; Palterer, B.; Bosticardo, M.; Pala, F.; Viel, S.; Malech, H. L.; Ghanim, H. Y.; Bode, N. N.; Kurgan, G. L.; Vakulskas, C. A.; Sheikali, A.; Menezes, S. T.; Chrobok, J.; Gonzalez, E. M. H.; Majeti, R.; Notarangelo, L. D.; Porteus, M. H.
10.1101/2022.07.12.499831 — immunology — Posted on 2022-07-13
2440 Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies
Venkatesan, V.; Christopher, A. C.; Babu, P.; Azhagiri, M. K. K.; Walavalkar, K.; Saravanan, B.; Srinivasan, S.; Karuppusamy, K. V.; Jacob, A.; Rangaraj, S.; Bagchi, A.; Pai, A. A.; Nakamura, Y.; Balasubramanian, P.; Pai, R.; Marepally, S. K.; Mohankumar, K. M.; Velayudhan, S. R.; Notani, D.; Srivastava, A.; Thangavel, S.
10.1101/2022.07.11.499646 — biochemistry — Posted on 2022-07-13
2441 Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation
Jia, X.; Chin, Y. K.- Y.; Zhang, A. H.; Crawford, T.; Zhu, Y.; Fletcher, N. L.; Zhou, Z.; Hamilton, B. R.; Stroet, M.; Thurecht, K. J.; Mobli, M.
10.1101/2022.07.12.499226 — biochemistry — Posted on 2022-07-13
2445 Nanoparticle mediated in vitro and in vivo CRISPR base correction of LCA16 causing nonsense mutation rescues Kir7.1 channel function
Kabra, M.; Shahi, P. K.; Wang, Y.; Sinha, D.; Spillane, A.; Newby, G. A.; Saxsena, S.; Edwards, K.; Thiesen, C.; Gamm, D.; Liu, D. R.; Gong, S. S.; Saha, K.; Pattnaik, B. R.
10.1101/2022.07.12.499808 — genetics — Posted on 2022-07-13
2446 DNA methylation and proteomics integration uncover dose-dependent group and individual responses to exercise in human skeletal muscle
Jacques, M.; Landen, S.; Alvarez-Romero, J.; Hiam, D.; Schittenhelm, R. B.; Hanchapola, I.; Shah, A.; Eynon, N.
10.1101/2022.07.11.499662 — molecular biology — Posted on 2022-07-13
2447 Protein Structure Prediction with Expectation Reflection
Cresswell-Clay, E. C.; Hoang, D.-T.; McKenna, J.; Yang, C.; Zhang, E.; Periwal, V.
10.1101/2022.07.12.499755 — molecular biology — Posted on 2022-07-13
2449 Identification and Characterization of Probiotics Isolates from Indigenous Chicken (Gallus domesticus) of Nepal
Gupta, M.; Raut, R.; Manandhar, S.; Chaudhary, A.; Shrestha, U.; Dangol, S.; GC, S.; Budha, K. R.; Karki, G.; Sanchez, S. D.; Gortazar, C.; de la Fuente, J.; Rajbhandari, P. G.; Manandhar, P.; Napit, R.; Karmacharya, D.
10.1101/2022.07.12.499701 — microbiology — Posted on 2022-07-13
2450 Cellular senescence preserves viral genome maintenance
Pham, A. M.; Ortiz, L. E.; Lukacher, A. E.; Kwun, H. J.
10.1101/2022.07.12.499783 — microbiology — Posted on 2022-07-13
2451 A needle in a haystack: a new metabarcoding approach to survey diversity at the species level of Arcellinida (Amoebozoa: Tubulinea)
Gonzalez-Miguens, R.; Cano, E.; Guillen-Oterino, A.; Quesada, A.; Lahr, D. J. G.; Tenorio-Rodriguez, D.; Salvador-Velasco, D. d.; Velazquez, D.; Carrasco-Braganza, M. I.; Patterson, T. R.; Lara, E.; Singer, D.
10.1101/2022.07.12.499778 — microbiology — Posted on 2022-07-13
2452 Talaromyces marneffei suppresses human macrophages inflammatory by producing the truncated protein NCOR2-013 via TUT1-regulated alternative splicing
Wei, W.; Wang, G.; Zhang, H.; Bao, X.; An, S.; Luo, Q.; He, J.; Chen, L.; Liu, Y.; Ning, C.; Lai, J.; Yuan, Z.; Chen, R.; Jiang, J.; Ye, L.; Liang, H.
10.1101/2022.07.11.499655 — microbiology — Posted on 2022-07-13
2454 acCRISPR: An activity-correction method for improving the accuracy of CRISPR screens
Ramesh, A.; Trivedi, V.; Schwartz, C.; Tafrishi, A.; Mohseni, A.; Li, M.; Lonardi, S.; Wheeldon, I.
10.1101/2022.07.12.499789 — synthetic biology — Posted on 2022-07-13
2455 Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: A feedback inhibition mechanism of the menaquinone biosynthesis pathway
Stanborough, T.; Ho, N. A. T.; Bulloch, E. M. M.; Bashiri, G.; Dawes, S. S.; Akazong, E. W.; Titterington, J.; Allison, T. M.; Jiao, W.; Johnston, J. M.
10.1101/2022.07.12.499824 — biochemistry — Posted on 2022-07-13
2456 Linking Parasitism to Network Centrality and the Impact of Sampling Bias in its Interpretation
XU, Z.; MacIntosh, A. J. J.; Castellano-Navarro, A.; Macanas-Martinez, E.; Suzumura, T.; Duboscq, J.
10.1101/2021.06.07.447302 — animal behavior and cognition — Posted on 2022-07-12
2460 Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming.
Keine, C.; Al-Yaari, M.; Radulovic, T.; Thomas, C. I.; Valino Ramos, P.; Guerrero-Given, D.; Kamasawa, N.; Young, S. M.
10.1101/2022.06.29.497712 — neuroscience — Posted on 2022-07-12
2462 Beyond energy balance in agrivoltaic food production: Emergent crop traits from wavelength-selective solar cells
Charles, M.; Edwards, B.; Ravishankar, E.; Calero, J.; Henry, R.; Rech, J.; Saravitz, C.; You, W.; Ade, H.; O'Connor, B. T.; Sederoff, H.
10.1101/2022.03.10.482833 — plant biology — Posted on 2022-07-12
2464 Phylogenetic resolution of the Cannabis genus reveals extensive admixture
Halpin-McCormick, A.; Heyduk, K.; Kantar, M.; Batora, N.; Masalia, R.; Law, K.; Kuntz, E.
10.1101/2022.07.09.499013 — genomics — Posted on 2022-07-12
2465 Rapid and transient evolution of local adaptation to seasonal host fruits in an invasive pest fly
Olazcuaga, L.; Foucaud, J.; Deschamps, C.; Loiseau, A.; Claret, J.-L.; Vedovato, R.; Guilhot, R.; Sevely, C.; Gautier, M.; Hufbauer, R. A.; Rode, N. O.; Estoup, A.
10.1101/2022.03.01.482503 — evolutionary biology — Posted on 2022-07-12
2467 Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender
Fleming, S. J.; Chaffin, M. D.; Arduini, A.; Akkad, A.-D.; Banks, E.; Marioni, J. C.; Philippakis, A. A.; Ellinor, P. T.; Babadi, M.
10.1101/791699 — bioinformatics — Posted on 2022-07-12
2468 Unifying the Identification of Biomedical Entities with the Bioregistry
Hoyt, C. T.; Balk, M.; Callahan, T. J.; Domingo-Fernandez, D.; Haendel, M. A.; Hegde, H. B.; Himmelstein, D. S.; Karis, K.; Kunze, J.; Lubiana, T.; Matentzoglu, N.; McMurry, J.; Moxon, S.; Mungall, C. J.; Rutz, A.; Unni, D. R.; Willighagen, E.; Winston, D.; Gyori, B. M.
10.1101/2022.07.08.499378 — bioinformatics — Posted on 2022-07-12
2470 Increased early sodium current causes familial atrial fibrillation and dampens effect of flecainide
O'Reilly, M.; Sommerfeld, L. C.; O'Shea, C.; Broadway-Stringer, S.; Andaleeb, S.; Reyat, J. S.; Kabir, S. N.; Stastny, D.; Malinova, A.; Delbue, D.; Fortmueller, L.; Gehmlich, K.; Pavlovic, D.; Skryabin, B. V.; Holmes, A. P.; Kirchhof, P.; Fabritz, L.
10.1101/2022.01.18.476646 — molecular biology — Posted on 2022-07-12
2475 Taxane chemotherapy leads to breast cancer dormancy escape by stromal injury mediated IL-6/MAP2K signaling
Ganesan, R.; Bhasin, S. S.; Krishnan, U.; Thomas, B. E.; Cheemarla, N. R.; Bhasin, M. K.; Sukhatme, V. P.
10.1101/2022.07.10.499472 — cancer biology — Posted on 2022-07-12
2476 Comprehensive function annotation of metagenomes and microbial genomes using a deep learning-based method
Maranga, M.; Szczerbiak, P.; Bezshapkin, V.; Gligorijevic, V.; Chandler, C.; Bonneau, R.; Xavier, R. J.; Kosciolek, T.; Vatanen, T.
10.1101/2022.06.06.494653 — bioinformatics — Posted on 2022-07-12
2477 Annotation of Spatially Resolved Single-cell Data with STELLAR
Brbic, M.; Cao, K.; Hickey, J. W.; Tan, Y.; Snyder, M.; Nolan, G. P.; Leskovec, J.
10.1101/2021.11.24.469947 — bioinformatics — Posted on 2022-07-12
2478 Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: a pilot study
Racine, K. C.; Iglesias-carres, L.; Herring, J.; Ferruzzi, M.; Kay, C.; Tessem, J.; Neilson, A. P.
10.1101/2022.04.27.489764 — biochemistry — Posted on 2022-07-12
2480 Impacts of sex ratio meiotic drive on genome structure and defense in a stalk-eyed fly
Reinhardt, J. A.; Baker, R. H.; Zimin, A. V.; Ladias, C.; Paczolt, K.; Werren, J. H.; Hayashi, C. Y.; Wilkinson, G. S.
10.1101/2020.09.23.310227 — evolutionary biology — Posted on 2022-07-12
2482 Helical metaphase chromatid coiling is conserved
Kubalova, I.; Camara, A. S.; Capal, P.; Beseda, T.; Rouillard, J.-M.; Krause, G. M.; Toegelova, H.; Himmelbach, A.; Stein, N.; Houben, A.; Dolezel, J.; Mascher, M.; Simkova, H.; Schubert, V.
10.1101/2021.09.16.460607 — cell biology — Posted on 2022-07-12
2483 The Endocytic Recycling Compartment Serves as a Viral Factory for Hepatitis E Virus
Bentaleb, C.; Hervouet, K.; Montpellier, C.; Camuzet, C.; Ferrie, M.; Burlaud-Gaillard, J.; Bressanelli, S.; Metzger, K.; Werkmeister, E.; Ankavay, M.; Janampa, N. L.; Marlet, J.; Roux, J.; Deffaud, C.; Goffard, A.; Rouille, Y.; Dubuisson, J.; Roingeard, P.; Aliouat-Denis, C.-M.; Cocquerel, L.
10.1101/2021.10.14.464345 — microbiology — Posted on 2022-07-12
2485 Plankton-infecting relatives of herpesviruses clarify the evolutionary trajectory of giant viruses
Gaia, M.; Meng, L.; Pelletier, E.; Forterre, P.; Vanni, C.; Fernendez-Guerra, A.; Jaillon, O.; Wincker, P.; Ogata, H.; Krupovic, M.; Delmont, T. O.
10.1101/2021.12.27.474232 — evolutionary biology — Posted on 2022-07-12
2486 Efficient Dlx2-mediated astrocyte-to-neuron conversion and inhibition of neuroinflammation by NeuroD1
Liu, M.-H.; Xu, Y.-G.; Bai, X.-N.; Lin, J.-H.; Xiang, Z.-Q.; Wang, T.; Xu, L.; Li, W.; Chen, G.
10.1101/2022.07.11.499522 — neuroscience — Posted on 2022-07-12
2487 Delivery of loaded MR1 Monomer Results in Efficient Ligand Exchange to Host MR1 and Subsequent MR1T cell activation
Kulicke, C. A.; Swarbrick, G. M.; Ladd, N. A.; Cansler, M.; Null, M.; Worley, A.; Lemon, C.; Ahmed, T.; Bennett, J.; Lewinsohn, D. A.; Adams, E. J.; Lewinsohn, D. M.; Harriff, M. J.
10.1101/2022.07.11.499573 — immunology — Posted on 2022-07-12
2488 PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth
Cleveland, A. H.; Malawsky, D.; Churiwal, M.; Rodriguez, C.; Reed, F.; Schniederjan, M.; Velazquez Vega, J. E.; Davis, I.; Gershon, T. R.
10.1101/2022.07.11.499567 — neuroscience — Posted on 2022-07-12
2489 Converging pathways found in copy number variation syndromes with high schizophrenia risk
Ehrhart, F.; Silva, A.; Amelsvoort, T.; von Scheibler, E.; Evelo, C.; Linden, D. E. J.
10.1101/2022.02.07.479370 — systems biology — Posted on 2022-07-12
2491 Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures
Clairet, C.; LAPALU, N.; Simon, A.; Soyer, J. L.; Viaud, M.; Zehraoui, E.; Dalmais, B.; Fudal, I.; Ponts, N.
10.1101/2021.04.16.439968 — genomics — Posted on 2022-07-12
2496 Use of vivo-morpholinos for gene knockdown in the postnatal shark retina
Rodriguez-Arrizabalaga, M.; Hernandez-Nunez, I.; Candal, E.; Barreiro-Iglesias, A.
10.1101/2022.07.11.499558 — neuroscience — Posted on 2022-07-12
2498 BepiPred-3.0: Improved B-cell epitope prediction using protein language models
Clifford, J.; Hoeie, M. H.; Nielsen, M.; Deleuran, S.; Peters, B.; Marcatili, P.
10.1101/2022.07.11.499418 — bioinformatics — Posted on 2022-07-12
2500 Multiple invasions, Wolbachia and human-aided transport drive the genetic variability of Aedes albopictus in the Iberian Peninsula
Lucati, F.; Delacour, S.; Palmer, J. R. B.; Caner, J.; Oltra, A.; Paredes-Esquivel, C.; Mariani, S.; Escartin, S.; Roiz, D.; Collantes, F.; Bengoa, M.; Montalvo, T.; Delgado, J. A.; Eritja, R.; Lucientes, J.; Albo Timor, A.; Bartumeus, F.; Ventura, M.
10.1101/2022.07.11.499514 — genetics — Posted on 2022-07-12
2503 Efficient Human Germ Cell Specification from Stem Cells via Combinatorial Expression of Transcription Factors
Kramme, C.; Smela, M. P.; Wolf, B.; Fortuna, P. R.; Brixi, G.; Palepu, K.; Dong, E.; Adams, J. L.; Bhat, S.; Koseki, S.; Tysinger, E.; Stan, T.; Kohman, R. E.; Liu, S.; Kobayashi, M.; Shioda, T.; Church, G. M.; Chatterjee, P.
10.1101/2022.07.11.499564 — developmental biology — Posted on 2022-07-12
2504 A comprehensive analysis of the gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs
Thomsen, M.; Kuenstner, A.; Wohlers, I.; Olbrich, M.; Lenfers, T.; Osumi, T.; Shimazaki, Y.; Nishifuji, K.; Ibrahim, S. M.; Watson, A.; Busch, H.; Hirose, M.
10.1101/2022.07.11.497949 — microbiology — Posted on 2022-07-12
2505 Small gene networks can delineate immune cell states and characterize immunotherapy response in melanoma
Egan, D.; Kreileder, M.; Nabhan, M.; Iglesias-Martinez, L. F.; Dovedi, S.; Valge-Archer, V.; Grover, A.; Wilkinson, R.; Slidel, T.; Bendtsen, C.; Barrett, I.; Brennan, D.; Kolch, W.; Zhernovkov, V.
10.1101/2022.07.11.498823 — immunology — Posted on 2022-07-12
2506 Nucleic acid receptor ligands improve vaccination efficacy against the filarial nematode Litomosoides sigmodontis
Scheunemann, J. F.; Risch, F.; Reichwald, J. J.; Lenz, B.; Neumann, A.-L.; Garbe, S.; Frohberger, S. J.; Koschel, M.; Ajendra, J.; Rothe, M.; Latz, E.; Coch, C.; Hartmann, G.; Schumak, B.; Hoerauf, A.; Hübner, M. P.
10.1101/2022.07.11.499516 — immunology — Posted on 2022-07-12
2508 Holographic stimulation of opposing amygdala ensembles bidirectionally modulates valence-specific behavior
Piantadosi, S. C.; Zhou, Z. C.; Pizzano, C. M.; Pedersen, C. E.; Nguyen, T. K.; Thai, S.; Stuber, G. D.; Bruchas, M. R.
10.1101/2022.07.11.499499 — neuroscience — Posted on 2022-07-12
2509 NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
Oliveira, D. V.; Coupland, K.; Jin, S.; Del Gaudio, F.; Wang, S.; Fox, R.; Rutten, J. W.; Sandin, J.; Lundkvist, J.; Lesnik Oberstein, S. A.; Lendahl, U.; Karlstrom, H.
10.1101/2022.07.11.499563 — neuroscience — Posted on 2022-07-12
2510 Growth mindset promotes children's working memory performance through cortico-striatal interaction and fronto-parietal activation
Zhao, Y.; Xu, J.; Chen, M.; Hao, L.; He, Y.; Wang, H.; Wang, Y.; Wang, D.; Han, Z. R.; Tan, S.; Men, W.; Gao, J.; He, Y.; Tao, S.; Dong, Q.; Qin, S.
10.1101/2022.07.11.499525 — neuroscience — Posted on 2022-07-12
2512 Insights from Incorporating Quantum Computing into Drug Design Workflows
Lau, B.; Emani, P. S.; Chapman, J.; Yao, L.; Lam, T.; Merrill, P.; Warrell, J.; Gerstein, M. B.; Lam, H.
10.1101/2022.07.11.499644 — bioinformatics — Posted on 2022-07-12
2515 Reductive evolution in the structure of the microsporidian proteasome.
Jespersen, N.; Ehrenbolger, K.; Winiger, R. R.; Svedberg, D.; Vossbrinck, C. R.; Barandun, J.
10.1101/2022.07.11.499521 — evolutionary biology — Posted on 2022-07-12
2516 LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function
Bunatyan, L.; Margineanu, A.; Boutin, C.; Montcouquiol, M.; Bachmann, S.; Ilso Christensen, E.; Willnow, T.; Christ, A.
10.1101/2022.07.12.499714 — cell biology — Posted on 2022-07-12
2517 Enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants BA.4 and BA.5
Reuschl, A.-K.; Thorne, L. G.; Whelan, M. X. V.; Mesner, D.; Ragazzini, R.; Dowgier, G.; Bogoda, N.; Turner, J. E.; Furnon, W.; Cowton, V. M.; de Lorenzo, G.; Bonfanti, P.; Palmarini, M.; Patel, A. H.; Jolly, C.; Towers, G. J.
10.1101/2022.07.12.499603 — microbiology — Posted on 2022-07-12
2521 Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway
Lerche, M.; Mathieu, M.; Malerod, L.; Pedersen, N. M.; Hamidi, H.; Chastney, M.; Bruininks, B. M. H.; Kaptan, S.; Jacquemet, G.; Vattulainen, I.; Roca-Cusachs, P.; Brech, A.; Perez, F.; Boncompain, G.; Miserey, S.; Ivaska, J.
10.1101/2022.07.12.498931 — cell biology — Posted on 2022-07-12
2522 Characterising replisome disassembly in human cells
Jones, R.; Herrero Ruiz, J.; Scaramuzza, S.; Nath, S.; Henklewska, M.; Natsume, T.; Romero, F.; Kanemaki, M.; Gambus, A.
10.1101/2022.07.12.499744 — cell biology — Posted on 2022-07-12
2523 Automatic detection of spatio-temporal signalling patterns in cell collectives
Gagliardi, P. A.; Grädel, B.; Jacques, M.-A.; Hinderling, L.; Ender, P.; Cohen, A. R.; Kastberger, G.; Pertz, O.; Dobrzynski, M.
10.1101/2022.07.12.499734 — cell biology — Posted on 2022-07-12
2524 Cryo-EM structures of α-synuclein filaments from Parkinson's disease and dementia with Lewy bodies
Yang, Y.; Shi, Y.; Schweighauser, M.; Zhang, X.; Kotecha, A.; Murzin, A. G.; Garringer, H. J.; Cullinane, P. W.; Saito, Y.; Foroud, T.; Wagner, T. T.; Hasegawa, K.; Vidal, R.; Murayama, S.; Revesz, T.; Ghetti, B.; Hasegawa, M.; Lashley, T.; Scheres, S.; Goedert, M.
10.1101/2022.07.12.499706 — neuroscience — Posted on 2022-07-12
2526 The Functional Landscape of SARS-CoV-2 3CL Protease
Iketani, S.; Hong, S. J.; Sheng, J.; Bahari, F.; Culbertson, B.; Atanaki, F. F.; Aditham, A. K.; Kratz, A. F.; Luck, M. I.; Tian, R.; Goff, S. P.; Montazeri, H.; Sabo, Y.; Ho, D. D.; Chavez, A.
10.1101/2022.06.23.497404 — microbiology — Posted on 2022-07-12
2532 Metastable Oscillatory Modes emerge from Synchronization in the Brain Spacetime Connectome
Cabral, J.; Castaldo, F.; Vohryzek, J.; Litvak, V.; Bick, C.; Lambiotte, R.; Friston, K.; Kringelbach, M. L.; Deco, G.
10.1101/2022.01.06.475196 — neuroscience — Posted on 2022-07-12
2535 SHAPR predicts 3D cell shapes from 2D microscopic images
Waibel, D.; Kiermeyer, N.; Atwell, S.; Sadafi, A.; Meier, M.; Marr, C.
10.1101/2021.09.29.462353 — bioinformatics — Posted on 2022-07-12
2536 MC profiling: a novel approach to analyze DNA methylation heterogeneity in genome-wide bisulfite sequencing data
De Riso, G.; Sarnataro, A.; Scala, G.; Cuomo, M.; Della Monica, R.; Amente, S.; Chiariotti, L.; Miele, G.; Cocozza, S.
10.1101/2022.07.06.498979 — bioinformatics — Posted on 2022-07-12
2538 Multi-omics comparison of malignant and normal uveal melanocytes reveals novel molecular features of uveal melanoma.
Gentien, D.; Saberi-Ansari, E.; Servant, N.; Jolly, A.; De la Grange, P.; Nemati, F.; Liot, G.; Saule, S.; Teissandier, A.; Bourc'his, D.; Girard, E.; Wong, J.; Masliah-Planchon, J.; Rodrigues, M.; Villoing Gaude, L.; Reyes, C.; Bazire, M.; Chenegros, T.; Bohec, M.; Baulande, S.; M'kacher, R.; Jeandidier, E.; Nicolas, A.; Decaudin, D.; Cassoux, N.; Piperno-Neumann, S.; Stern, M.-H.; Gibcus, J. H.; Dekker, J.; Heard, E.; Roman-Roman, S.; Waterfall, J. J.
10.1101/2022.03.11.483767 — genomics — Posted on 2022-07-12
2539 Systematic identification of cis-interacting lncRNAs and their targets
Agrawal, S.; Kulakovskiy, I. V.; Severin, J.; Koido, M.; Alam, T.; Abugessaisa, I.; Buyan, A.; Chang, H. Y.; Dostie, J.; Itoh, M.; Kere, J.; Kondo, N.; Li, Y.; Makeev, V. J.; Mendez, M.; Okazaki, Y.; Ramilowski, J. A.; Sigorskikh, A. I.; Strug, L. J.; Yagi, K.; Yasuzawa, K.; Yip, C. W.; Hon, C.-C.; Hoffman, M. M.; Terao, C.; Kasukawa, T.; Shin, J. W.; Carninci, P.; de Hoon, M. J. L.
10.1101/2021.01.13.426305 — genomics — Posted on 2022-07-12
2540 On distinguishing between canonical tRNA genes and tRNA gene fragments in prokaryotes
van der Gulik, P. T. S.; Egas, M.; Kraaijeveld, K.; Dombrowski, N.; Groot, A. T.; Spang, A.; Hoff, W. D.; Gallie, J.
10.1101/2022.07.05.498093 — genomics — Posted on 2022-07-12
2542 Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET
Dutka, P.; Metskas, L. A.; Hurt, R. C.; Salahshoor, H.; Wang, T.-Y.; Malounda, D.; Lu, G.; Chou, T.-F.; Shapiro, M. G.; Jensen, G. J.
10.1101/2022.06.21.496981 — molecular biology — Posted on 2022-07-12
2545 A novel attention-based peptide language model for dipeptidyl peptidase-IV inhibitory peptides mining
Guan, C.; Luo, J.; Li, S.; Tan, Z. L.; Li, J.; Wu, Z.; Wang, Y.; Chen, H.; Yamamoto, N.; Zhang, C.; Chen, J.; Xing, X.-H.
10.1101/2022.06.13.495896 — bioinformatics — Posted on 2022-07-12
2550 Interrogating the effect of enzyme kinetics on metabolism using differentiable constraint-based models
Wilken, S. E.; Besancon, M.; Kratochvil, M.; Kuate, C. A. F.; Trefois, C.; Gu, W.; Ebenhoeh, O.
10.1101/2022.07.11.499575 — bioengineering — Posted on 2022-07-11
2554 Activating and repressing gene expression between chromosomes during stochastic fate specification
Urban, E. A.; Chernoff, C.; Viets-Layng, K.; Han, J.; Anderson, C.; Konzman, D.; Johnston, R. J.
10.1101/2022.07.11.499628 — developmental biology — Posted on 2022-07-12
2555 An Open Microfluidic Coculture Model of Fibroblasts and Eosinophils to Investigate Mechanisms of Airway Inflammation
Zeng, Y.; Su, X.; Takezawa, M. G.; Fichtinger, P. S.; Lee, U. N.; Pippin, J. W.; Shankland, S. J.; Lim, F. Y.; Denlinger, L. C.; Jarjour, N. N.; Mathur, S. K.; Sandbo, N.; Berthier, E.; Esnault, S.; Bernau, K.; Theberge, A. B.
10.1101/2022.07.11.499658 — cell biology — Posted on 2022-07-11
2556 Autocrine Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts
Mayr, C. H.; Sengupta, A.; Ansari, M.; Pestoni, J.; Ogar, P.; Angelidis, I.; Liontos, A.; Rodriguez, J. A.; Lang, N. J.; Strunz, M.; Ashgarpour, S.; Gonzalez, D.; Gerckens, M.; Oehrle, B.; Viteri, V.; Fernandez, I.; Tallquist, M. V.; Irmler, M.; Beckers, J.; Eickelberg, O.; Stoleriu, G. M.; Behr, J.; Kneidinger, N.; Yildirim, O. A.; Ahlbrecht, K.; Morty, R.; Samakovlis, C.; Theis, F. J.; Burgstaller, G.; Schiller, H. B.
10.1101/2022.07.11.499594 — cell biology — Posted on 2022-07-12
2557 Re-emergence of Severe Acute Diarrhea Syndrome Coronavirus (SADS-CoV) in Guangxi, China, 2021
Sun, Y.; Xing, J.; Xu, Z.; Gao, H.; Xu, S.; Liu, J.; Zhu, D.; Guo, Y.; Yang, B.; Chen, X.; Wang, H.; Gong, L.; Zheng, Z.; Holmes, E. C.; Zhang, G.
10.1101/2022.07.11.499512 — microbiology — Posted on 2022-07-12
2558 Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells
Chew, K.; Lee, B.; Van Haren, S.; Nanishi, E.; O'Meara, T. R.; Splaine, J. B.; De Leon, M.; Soni, D.; Seo, H.-S. R.; Dhe-Paganon, S.; Ozonoff, A.; Smith, J. A.; Levy, O.; Dowling, D. J.
10.1101/2022.06.17.496630 — immunology — Posted on 2022-07-11
2561 Tetraspanin 4 mediates migrasome formation via a two-stage mechanism
Dharan, R.; Huang, Y.; Cheppali, S. K.; Goren, S.; Shendrik, P.; Kozlov, M. M.; Yu, L.; Sorkin, R.
10.1101/2022.07.11.499540 — biophysics — Posted on 2022-07-11
2563 SNVformer: An Attention-based Deep Neural Network for GWAS Data
Elmes, K.; Benavides-Prado, D.; Tan, N. O.; Nguyen, T. B.; Sumpter, N.; Leask, M.; Witbrock, M.; Gavryushkin, A.
10.1101/2022.07.07.499217 — bioinformatics — Posted on 2022-07-11
2565 Structural basis of human PRPS2 filaments
Lu, G.-M.; Hu, H.-H.; Chang, C.-C.; Zhong, J.; Zhou, X.; Guo, C.-J.; Zhang, T.; Li, Y.-L.; Yin, B.; Liu, J.-L.
10.1101/2022.07.11.499506 — biochemistry — Posted on 2022-07-11
2567 Drosophila SUMM4 complex couples insulator function and DNA replication timingcontrol
Andreyeva, E. N.; Emelyanov, A. V.; Nevil, M.; Sun, L.; Vershilova, E.; Hill, C. A.; Keogh, M. C.; Duronio, R. J.; Skoultchi, A. I.; Fyodorov, D. V.
10.1101/2021.10.02.462895 — biochemistry — Posted on 2022-07-11
2569 The global distribution and environmental drivers of the soil antibiotic resistome
Delgado-Baquerizo, M.; Hu, H.-W.; Maestre, F. T.; Guerra, C. A.; Eisenhauer, N.; Eldridge, D. J.; Zhu, Y.-G.; Chen, Q.-L.; Trivedi, P.; Du, S.; Makhalanyane, T. P.; Verma, J. P.; Gozalo, B.; Ochoa, V.; Asensio, S.; Wang, L.; Zaady, E.; Illan, J. G.; Siebe, C.; Grebenc, T.; Zhou, X.; Liu, Y.-R.; Bamigboye, A. R.; Blanco-Pastor, J. L.; Duran, J.; Rodriguez, A.; Mamet, S.; Alfaro, F.; Abades, S.; Teixido, A. L.; Penaloza-Bojaca, G. F.; Molina-Montenegro, M.; Torres-Diaz, C.; Perez, C.; Gallardo, A.; Garcia-Velazquez, L.; Hayes, P. E.; Neuhauser, S.; He, J.-Z.
10.1101/2022.07.11.499543 — ecology — Posted on 2022-07-11
2570 Mechano-epigenetic regulation of extracellular matrix homeostasis via Yap and Taz
Jones, D. L.; Daniels, R. N.; Jiang, X.; Locke, R. C.; Evans, M. K.; Bonnevie, E. D.; Srikumar, A.; Nijsure, M. P.; Boerckel, J. D.; Mauck, R. L.; Dyment, N. A.
10.1101/2022.07.11.499650 — cell biology — Posted on 2022-07-11
2571 Optimised DNA isolation from marine sponges for natural sampler DNA (nsDNA) metabarcoding
Harper, L. R.; Neave, E. F.; Sellers, G. S.; Cunnington, A. V.; Arias, M. B.; Craggs, J.; MacDonald, B.; Riesgo, A.; Mariani, S.
10.1101/2022.07.11.499619 — molecular biology — Posted on 2022-07-11
2573 Kynurenic acid promotes A1 to A2 astrocyte conversion against HIV-associated neurocognitive disorder
Lun, J.; Li, Y.; Gao, X.; Gong, Z.; Chen, X.; Zou, J.; Zhou, C.; Huang, Y.; Zhou, B.; Huang, P.; Cao, H.
10.1101/2022.07.11.499523 — microbiology — Posted on 2022-07-11
2574 Antiviral function and viral antagonism of the rapidly evolving dynein activating adapter NINL
Stevens, D. A.; Beierschmitt, C.; Mahesula, S.; Corley, M. R.; Salogiannis, J.; Tsu, B. V.; Cao, B.; Ryan, A. P.; Reck-Peterson, S. L.; Daugherty, M. D.
10.1101/2022.07.11.499552 — microbiology — Posted on 2022-07-11
2575 A novel prion strain is responsible for the first case of chronic wasting disease in Finnish moose
Sun, J. L.; Bian, J.; Kim, S.; Crowell, J.; Webster, B. K.; Raisley, E. K.; Korpenfelt, S.-L.; Benestad, S. L.; Telling, G. C.
10.1101/2022.07.11.499602 — microbiology — Posted on 2022-07-11
2577 Determining probabilities of HIV-1 bNAb development in healthy and chronically infected individuals
Kreer, C.; Lupo, C.; Ercanoglu, M. S.; Gieselmann, L.; Spisak, N.; Grossbach, J.; Schlotz, M.; Schommers, P.; Gruell, H.; Dold, L.; Beyer, A.; Nourmohammad, A.; Mora, T.; Walczak, A.; Klein, F.
10.1101/2022.07.11.499584 — immunology — Posted on 2022-07-11
2580 Homeostatic responses to hypoxia by the carotid body and adrenal medulla are based on mutual antagonism between HIF-1α and HIF-2α
Yuan, G.; Peng, Y.-J.; Reddy, V. D.; Makarenko, V.; Nanduri, J.; Khan, S. A.; Garcia, J. A.; Kumar, G. K.; Semenza, G. L.; Prabhakar, N. R.
10.1101/2022.07.11.499380 — physiology — Posted on 2022-07-11
2581 Biotext: Exploiting Biological-like format for text mining
Machado, D. J. S.; De Pierri, C. R.; Santos, L. G. C.; Scapin, L.; da Silva Filho, A. C.; Perico, C. P.; Pedrosa, F. O.; Raittz, R. T.
10.1101/2021.04.08.439078 — bioinformatics — Posted on 2022-07-11
2582 Approximating Scaffold Printability Utilizing Computational Methods
Sedigh, A.; Ghelich, P.; Quint, J.; Samandari, M.; Tamayol, A.; Tomlinson, R. E.
10.1101/2022.07.11.499589 — bioengineering — Posted on 2022-07-11
2583 Structure of the histone acetyltransferase NuA4 complex
Zhang, H.; Ji, L.; Zhao, L.; Xu, K.; Gao, H.; Zhou, Y.; Kornberg, R. D.
10.1101/2022.07.11.499577 — biochemistry — Posted on 2022-07-11
2589 COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging
Vijaykumar, K.; Leung, H. M.; Barrios, A.; Fernandez-Petty, C. M.; Solomon, G. M.; Hathorne, H. Y.; Wade, J. D.; Monroe, K.; Slaten, K. B.; Li, Q.; Leal, S. M.; Moates, D. B.; Pierce, H. M.; Olson, K. R.; Currier, P.; Foster, S.; Marsden, D.; Tearney, G. J.; Rowe, S. M.
10.1101/2022.07.08.499336 — microbiology — Posted on 2022-07-11
2593 Landscape of infection enhancing antibodies in COVID-19 and healthy donors
Ismanto, H. S.; Xu, Z.; Saputri, D. S.; Wilamowski, J.; Li, S.; Nugraha, D. K.; Horiguchi, Y.; Okada, M.; Arase, H.; Standley, D. M.
10.1101/2022.07.09.499414 — immunology — Posted on 2022-07-11
2594 Directing Min protein patterns with advective bulk flow
Meindlhumer, S.; Brauns, F.; Finzgar, J. R.; Kerssemakers, J.; Dekker, C.; Frey, E.
10.1101/2021.12.23.474007 — biophysics — Posted on 2022-07-11
2596 Evolution of SARS-CoV-2 during the first year of the COVID-19 pandemic in Northwestern Argentina
Zambrana Montano, R.; Culasso, A.; Fernandez, F.; Marquez, N.; Debat, H.; Salmeron, M.; Zamora, A. M.; Ruiz de Huidobro, G.; Costas, D.; Alabarse, G.; Charre, M.; Fridman, A.; Mamani, C.; Vaca, F.; Maza Diaz, C.; Raskovsky, V.; Lavaque, E.; Lesser, V.; Cajal, P.; Aguero, F.; Calvente, C.; Torres, C.; Viegas, M.
10.1101/2022.07.08.499374 — bioinformatics — Posted on 2022-07-11
2601 Correspondence between the layered structure of deep language models and temporal structure of natural language processing in the human brain
Goldstein, A.; Ham, E.; Nastase, S. A.; Zada, Z.; Dabush, A.; Bobbi Aubrey, B.; Schain, M.; Gazula, H.; Feder, A.; Doyle, W.; Devore, S.; Dugan, P.; Friedman, D.; Brenner, M.; Hassidim, A.; Devinsky, O.; Flinker, A.; Levy, O.; Hasson, U.
10.1101/2022.07.11.499562 — neuroscience — Posted on 2022-07-11
2607 Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity
van den Bosch, R.; Hezemans, F. H.; Määttä, J. I.; Hofmans, L.; Papadopetraki, D.; Verkes, R.-J.; Marquand, A. F.; Booij, J.; Cools, R.
10.1101/2022.07.11.499570 — neuroscience — Posted on 2022-07-11
2608 Perturbations of a causal synaptic molecular network in autism and schizophrenia revealed with multiplexed imaging
Falkovich, R.; Danielson, E. W.; Perez de Arce, K.; Wamhoff, E.-C.; Cottrell, J. R.; Sheng, M.; Bathe, M.
10.1101/2022.07.11.499330 — neuroscience — Posted on 2022-07-11
2611 Accurate tropical forest individual tree crown delineation from RGB imagery using Mask R-CNN
Hickman, S. H. M.; Ball, J. G. C.; Jackson, T. D.; Koay, X. J.; Hirst, J.; Jay, W.; Aubry-Kientz, M.; Vincent, G.; Coomes, D. A.
10.1101/2022.07.10.499480 — ecology — Posted on 2022-07-11
2612 Parallel processing relies on a distributed, low-dimensional cortico-cerebellar architecture
Muller, E. J.; Hou, K.; Palesi, F.; Tan, J.; Close, T.; Gandini Wheeler-Kingshott, C. A. M.; D'Angelo, E. U.; Calamante, F.; Shine, J. M.
10.1101/2022.07.10.499497 — neuroscience — Posted on 2022-07-11
2613 Layer-specific, retinotopically-diffuse modulation in human visual cortex by emotional faces
Liu, T. T.; Fu, J. Z.; Chai, Y.; Japee, S.; Chen, G.; Ungerleider, L. G.; Merriam, E. P.
10.1101/2022.07.10.499443 — neuroscience — Posted on 2022-07-11
2615 An updated nomenclature for plant ribosomal protein genes
Scarpin, M. R.; Busche, M.; Martinez, R. E.; Harper, L. C.; Reiser, L.; Lan, T.; Xiong, W.; Mo, B.; Tang, G.; Chen, X.; Bailey-Serres, J.; Browning, K.; Brunkard, J. O.
10.1101/2022.07.06.498169 — plant biology — Posted on 2022-07-11
2617 Preparation of large biological samples for high-resolution, hierarchical, multi-modal imaging
Brunet, J.; Walsh, C. L.; Wagner, W. L.; Bellier, A.; Werlein, C.; Marussi, S.; Jonigk, D. D.; Verleden, S. E.; Ackermann, M.; Lee, P. D.; Tafforeau, P.
10.1101/2022.07.02.498430 — physiology — Posted on 2022-07-11
2618 Reliability metrics of outcome measures during the single and double leg drop jump tests
Celik, H.; Yildirim, A.; Unver, E.; Mavili, C.; Yilmaz, E.; Ozturk, F.; Arpinar-Avsar, P.; Cinemre, S. A.
10.1101/2022.07.10.499453 — physiology — Posted on 2022-07-11
2619 FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase
Chakraborty, A.; Dutta, A.; Dettori, L. G.; Li, J.; Gonzalez, L.; Xue, X.; Hehnly, H.; Sung, P.; Bah, A.; Feng, W.
10.1101/2022.07.10.499475 — biochemistry — Posted on 2022-07-11
2621 Unwilling or Unable? Using 3D tracking to evaluate dogs' reactions to differing human intentions.
Voelter, C. J.; Lonardo, L.; Steinmann, M. G. G. M.; Frizzo Ramos, C.; Gerwisch, K.; Schranz, M.-T.; Dobernig, I.; Huber, L.
10.1101/2022.07.09.499322 — animal behavior and cognition — Posted on 2022-07-11
2623 An Experimental Analysis of the Fine-Scale Effects of Nest Ectoparasites on Incubation Behavior
Hund, A. K.; McCahill, K. A.; Hernandez, M.; Turbek, S. P.; Ardia, D. R.; Terrien, R. C.; Safran, R. J.
10.1101/2022.07.09.499424 — animal behavior and cognition — Posted on 2022-07-11
2624 Human iPSC-derived neuron of 16p11.2 deletion reveals haplotype-specific expression of MAPK3 and its contribution to variable NDD phenotypes
Liu, F.; Liang, C.; Li, Z.; Zhao, S.; Shangguan, S.; Yuan, H.; Yao, R.; Qin, Z.; Zhang, S.; Zou, L.; Gao, Z.; Chen, Q.; Wen, S.; Peng, J.; Yin, F.; Chen, F.; Qiu, X.; Luo, J.; Xie, Y.; Lu, D.; Zhang, Y.; Xie, H.; Wang, H.; Cui, X.; Wang, J.; Huang, H.; Liu, R.; Sun, X.; Chen, C.; Wu, N.; Liu, C.; Shen, Y.; Gusella, J. F.; Chen, X.
10.1101/2022.07.10.498576 — genetics — Posted on 2022-07-11
2625 The Entwined African and Asian Genetic Roots of the Medieval Peoples of the Swahili Coast
Brielle, E. S.; Fleisher, J.; Wynne-Jones, S.; Broomandskhoshbacht, N.; Callan, K.; Curtis, E.; Iliev, L.; Lawson, A. M.; Oppenheimer, J.; Qiu, L.; Stewardson, K.; Workman, N.; Zalzala, F.; Ayodo, G.; Gidna, A.; Kabiru, A.; Kwekason, A.; Mabulla, A.; Manthi, F. K.; Ndiema, E.; Ogola, C.; Sawchuk, E.; Al-Gazali, L.; Ali, B. R.; Ben-Salem, S.; Letellier, T.; Pierron, D.; Radimilahy, C.; Rakotoarisoa, J.-A.; Culleton, B.; Mallick, S.; Rohland, N.; Patterson, N.; Mwenje, M. A.; Ahmed, K. B.; Mohamed, M. M.; Williams, S.; Monge, J.; Kusimba, S.; Prendergast, M.; Reich, D.; Kusimba, C.
10.1101/2022.07.10.499442 — genetics — Posted on 2022-07-11
2628 Loss of FOXP3 function causes expansion of two pools of autoreactive T cells in patients with IPEX syndrome.
Borna, S.; Lee, E.; Lakshmanan, U.; Mavers, M.; Narula, M.; Ramachandran, A.; Baker, J.; Schulze, J.; Olek, S.; Marois, L.; Gernez, Y.; Bhatia, M.; Bertaina, A.; Roncarolo, M. G.; Meffre, E.; Bacchetta, R.
10.1101/2022.07.10.499494 — immunology — Posted on 2022-07-11
2630 Amplified cortical neural responses as animals learn to use novel activity patterns
Akitake, B.; Douglas, H. M.; LaFosse, P. K.; Deveau, C. E.; Li, A. J.; Ryan, L. N.; Duffy, S. P.; Zhou, Z.; Deng, Y.; Histed, M. H.
10.1101/2022.07.10.499496 — neuroscience — Posted on 2022-07-11
2631 S-EBM: Generalising event-based modelling of disease progression for simultaneous events
Parker, C. S.; Oxtoby, N. P.; Alexander, D. C.; Zhang, H.; Alzheimer's Disease Neuroimaging Initiative,
10.1101/2022.07.10.499471 — neuroscience — Posted on 2022-07-11
2633 Transcriptomic cell type structures in vivo neuronal activity across multiple time scales.
Schneider, A.; Azabou, M.; McDougall-Vigier, L.; Parks, D. B.; Ensley, S.; Bhaskaran-Nair, K.; Nowakowski, T. J.; Dyer, E. L.; Hengen, K. B.
10.1101/2022.07.10.499487 — neuroscience — Posted on 2022-07-11
2634 Measurement of Cervical Neuronal Activity during Stress Challenge Using Novel Flexible Adhesive Surface Electrodes
Bu, Y.; Kurniawa, J. F.; Prince, J.; Nguyen, A. K. L.; Ho, B.; Sit, N. L. J.; Pham, T.; Wu, V. M.; Tjhia, B.; Shin, A. J.; Wu, T.-c.; Tu, X.; Rao, R.; Coleman, T. P.; Lerman, I.
10.1101/2022.07.10.499484 — physiology — Posted on 2022-07-11
2640 Sex-bias in utero alters ovarian reserve but not uterine capacity in female offspring
Geijer-Simpson, A. V.; Tinning, H.; de Bem, T. H. C.; Tsagakis, I.; Taylor, A. S.; Hume, L.; Collins, L.; Forde, N.
10.1101/2022.07.11.499550 — developmental biology — Posted on 2022-07-11
2648 Dissection of a complex enhancer cluster at the Sox2 locus
Brosh, R.; Coelho, C.; Ribeiro-dos-Santos, A. M.; Hogan, M. S.; Ashe, H. J.; Ellis, G.; Somogyi, N.; Ordonez, R.; Luther, R.; Huang, E.; Boeke, J. D.; Maurano, M. T.
10.1101/2022.06.20.495832 — genomics — Posted on 2022-07-11
2651 Diets affect the age-dependent decline of associative learning in Caenorhabditis elegans
Higurashi, S.; Tsukada, S.; Aleogho, B. M.; Park, J. H.; Tanaka, M.; Nakano, S.; Mori, I.; Noma, K.
10.1101/2020.10.08.331256 — neuroscience — Posted on 2022-07-11
2652 Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R, and GenePattern Notebook implementations of CoGAPS
Johnson, J. A. I.; Tsang, A.; Mitchell, J. T.; Davis-Marcisak, E. F.; Sherman, T.; Liefeld, T.; Loth, M.; Goff, L.; Zimmerman, J.; Kinny-Köster, B.; Jaffee, E.; Tamayo, P.; Mesirov, J.; Reich, M.; Fertig, E. J.; Stein-O'Brien, G. L.
10.1101/2022.07.09.499398 — systems biology — Posted on 2022-07-11
2653 Taxane chemotherapy leads to breast cancer dormancy escape by stromal injury mediated IL-6/MAP2K signaling
Ganesan, R.; Bhasin, S. S.; Krishnan, U.; Thomas, B. E.; Cheemarla, N. R.; Bhasin, M.; Sukhatme, V. P.
10.1101/2022.07.10.499472 — cancer biology — Posted on 2022-07-11
2654 Breast Cancer Reaction-Diffusion from Spectral-Spatial Analysis in Immunohistochemistry
Pasetto, S.; Zahid, M. U.; Diaz, R.; Montejo, M.; Rosa, M.; Gatenby, R.; Enderling, H.
10.1101/2022.07.10.499460 — cancer biology — Posted on 2022-07-11
2655 Small Molecule Antiviral Compound Collection (SMACC): a database to support the discovery of broad-spectrum antiviral drug molecules.
Martin, H.; Melo-Filho, C.; Korn, D.; Eastman, R.; Rai, G.; Simeonov, A.; Zakharov, A. V.; Muratov, E.; Tropsha, A.
10.1101/2022.07.09.499397 — bioinformatics — Posted on 2022-07-11
2660 Sex-bias in utero alters ovarian reserve but not uterine capacity in female offspring
Geijer-Simpson, A. V.; Forde, N.; de Bem, T. H. C.; Tsagakis, I.; Taylor, A. S.; Hume, L.; Collins, L.; Tinning, H.
10.1101/2022.07.11.499550 — developmental biology — Posted on 2022-07-11
2662 Targeting Acid Ceramidase Ameliorates Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis
Yu, A.; Cable, C.; Shihan, M. H.; Sharma, S.; Mattis, A. N.; Mileva, I.; Hannun, Y. A. N.; Duwaerts, C. C.; Chen, J. Y.
10.1101/2022.07.10.499388 — systems biology — Posted on 2022-07-11
2664 Tumor subclones, where are you?
Su, X.; Bai, S.; Xie, G.; Shi, Y.; Zhao, L.; Yang, G.; Tian, F.; He, K.-Y.; Wang, L.; Li, X.; Long, Q.; Han, Z.-G.
10.1101/2022.07.10.499466 — cancer biology — Posted on 2022-07-11
2665 Differentiated neuroblastoma cells remain epigenetically poised for de-differentiation to an immature state
Guyer, R.; Picard, N.; Mueller, J. L.; Murphy, A. J.; Cornejo, K.; Hotta, R.; Goldstein, A. M.
10.1101/2022.07.10.499470 — cancer biology — Posted on 2022-07-11
2668 baseLess: Lightweight detection of sequences in raw MinION data
Noordijk, B.; Nijland, R.; Carrion, V.; Raaijmakers, J.; de Ridder, D.; de Lannoy, C. V.
10.1101/2022.07.10.499286 — bioinformatics — Posted on 2022-07-11
2670 Katdetectr: utilising unsupervised changepoint analysis for robust kataegis detection
Hazelaar, D. M.; van Riet, J.; Hoogstrate, Y.; Lolkema, M. P.; van de Werken, H. J. G.
10.1101/2022.07.11.499364 — bioinformatics — Posted on 2022-07-11
2671 Accurate simultaneous sequencing of genetic and epigenetic bases in DNA
Fullgrabe, J.; Gosal, W. S.; Creed, P.; Liu, S.; Lumby, C. K.; Morley, D. J.; Ost, T. W. B.; Vilella, A. J.; Yu, S.; Bignell, H.; Burns, P.; Charlesworth, T.; Hodson, C.; Fu, B.; Fordham, H.; Harding, N.; Golder, P.; Li, M.; Lila, M.; Liu, Y.; Mellad, J.; Monahan, J.; Nentwich, O.; Palmer, A.; Steward, M.; Taipale, M.; Vandomme, A.; San-Bento, R. S.; Singhal, A.; Vivian, J.; Wojtowicz, N.; Williams, N.; Walker, N. J.; Wong, N. C. H.; Yalloway, G.; Holbrook, J. D.; Balasubramanian, S.
10.1101/2022.07.08.499285 — genomics — Posted on 2022-07-11
2674 Artisanal and farmers bread making practices differently shape fungal species diversity in French sourdoughs
Michel, E.; Masson, E.; Bubbendorf, S.; Lapicque, L.; Nidelet, T.; Segond, D.; Guezenec, S.; Marlin, T.; Devillers, H.; Rue, O.; Onno, B.; Legrand, J.; Sicard, D.
10.1101/679472 — ecology — Posted on 2022-07-11
2675 The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis
Pleuger, C.; Ai, D.; Hoppe, M. L.; Winter, L. T.; Bohnert, D.; Karl, D.; Guenther, S.; Epelman, S.; Kantores, C.; Fijak, M.; Ravens, S.; Middendorff, R.; Mayer, J. U.; Loveland, K. L.; Hedger, M. P.; Bhushan, S.; Meinhardt, A.
10.1101/2022.06.13.495924 — immunology — Posted on 2022-07-11
2676 Empowering systems-guided drug target discovery with metabolic and structural analysis
Chowdhury, S.; Zielinski, D. C.; Dalldorf, C.; Rodrigues, J. V.; Palsson, B.; Shakhnovich, E.
10.1101/2021.05.17.444532 — systems biology — Posted on 2022-07-11
2678 Patterning High to Low Heterogenous Fluid Shear Stress Landscapes with Multiphoton Inner Laser Lithography (MILL) for Live Cell Adhesion and Translocation
Lim, Y. J.; Zhang, J.; Lin, H.; Xu, T.; Li, Y.; Zhang, Z.; Hicks, S. M.; Chudinov, I.; Nechipurenko, D. Y.; Gardiner, E. E.; Lee, w. m.
10.1101/2022.06.17.496569 — bioengineering — Posted on 2022-07-11
2682 Light-inducible T cell engagers trigger, tune and shape the activation of primary T cells
Jaeger, M.; Anastasio, A.; Brustlein, S.; Vincentelli, R.; Durbesson, F.; Char, R.; Boussand, M.; Lechelon, M.; Arguello, R. J.; Marguet, D.; He, H.-T.; Lasserre, R.
10.1101/2022.04.15.488452 — immunology — Posted on 2022-07-11
2683 Ventral hippocampus-lateral septum circuitry promotes foraging-related memory
Decarie-Spain, L.; Liu, C. M.; Tierno Lauer, L.; Subramanian, K.; Bashaw, A. G.; Klug, M.; Gianatiempo, I. H.; Suarez, A. N.; Noble, E. E.; Donohue, K. N.; Cortella, A. M.; Hahn, J. D.; Davis, E. A.; Kanoski, S. E.
10.1101/2020.06.16.155721 — neuroscience — Posted on 2022-07-11
2686 Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence
Allen, B. K.; Kulkarni, M. M.; Chamberlain, B.; Dwight, T.; Koh, C.; Samant, R.; Jernigan, F.; Rice, J.; Tan, D.; Li, S.; Marino, K.; Huang, H.; Chiswick, E.; Tesar, B.; Sparks, S.; Lin, Z.; McGee, T. D.; Kolossvary, I.; Lin, C.; Shechter, S.; Soutter, H.; Bastos, C.; Taimi, M.; Lai, S.; Petrin, A.; Kane, T.; Swann, S.; Gardner, H.; Winter, C.; Sherman, W.
10.1101/2022.05.23.493001 — cancer biology — Posted on 2022-07-10
2687 Carriage of three plasmids in a single human clinical isolate of Clostridioides difficile
Roseboom, A. M.; Ducarmon, Q. R.; Hornung, B. V. H.; Harmanus, C.; Crobach, M. J. T.; Kuijper, E. J.; Vossen, R. H. A. M.; Kloet, S. L.; Smits, W. K.
10.1101/2022.07.10.499461 — microbiology — Posted on 2022-07-10
2688 Multimodal deep neural decoding of visual object representation in humans
Watanabe, N.; Miyoshi, K.; Jimura, K.; Shimane, D.; Keerativittayayut, R.; Nakahara, K.; Takeda, M.
10.1101/2022.04.06.487262 — neuroscience — Posted on 2022-07-10
2689 DeepSea: An efficient deep learning model for single-cell segmentation and tracking of time-lapse microscopy images
Zargari, A.; Lodewijk, G. A.; Mashhadi, N.; Cook, N. J.; Neudorf, C. W.; Araghbidikashani, K.; Rubio, S.; Hrabeta-Robinson, E.; Brooks, A. N.; Hinck, L.; Shariati, S. A.
10.1101/2021.03.10.434806 — systems biology — Posted on 2022-07-10
2691 The genome of Gynandropsis gynandra provides insights into whole-genome duplications and the evolution of C4 photosynthesis in Cleomaceae
Hoang, N. V.; Sogbohossou, E. O. D.; Xiong, W.; Simpson, C. J. C.; Singh, P.; van den Bergh, E.; Zhu, X.-G.; Brautigam, A.; Weber, A. P. M.; van Haarst, J. C.; Schijlen, E. G. W. M.; Hendre, P. S.; Van Deynze, A.; Achigan-Dako, E. G.; Hibberd, J. M.; Schranz, M. E.
10.1101/2022.07.09.499295 — plant biology — Posted on 2022-07-10
2693 Impact of gradient scheme and shimming on out-of-voxel echo artifacts in edited MRS
Song, y.; Zöllner, H. J.; Hui, S. C. N.; Hupfeld, K.; Oeltzschner, G.; Edden, R. A. E.
10.1101/2022.07.10.499491 — biophysics — Posted on 2022-07-10
2697 Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats
Herbst, A.; Choi, S.; Hoang, A.; Kim, C.; Martinez Moreno, D.; McKenzie, D.; Aiken, J.; Wanagat, J.
10.1101/2022.07.10.499455 — molecular biology — Posted on 2022-07-10
2698 Impact of pregravid obesity on anti-microbial fetal monocyte response
Sureshchandra, S.; Doratt, B. M.; Mendoza, N.; Varlamov, O.; Rincon, M.; Marshall, N. E.; Messaoudi, I.
10.1101/2022.07.10.499492 — immunology — Posted on 2022-07-10
2699 Temporal single cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury
Benhar, I.; Ding, J.; Yan, W.; Whitney, I. E.; Jacobi, A.; Sud, M.; Burgin, G.; Shekhar, K.; Tran, N. M.; Wang, C.; He, Z.; Sanes, J. R.; Regev, A.
10.1101/2022.07.10.499469 — immunology — Posted on 2022-07-10
2700 Identification and targeting of a unique NaV1.7 domain driving chronic pain
Gomez, K.; Stratton, H. J.; Duran, P.; Loya, S.; Tang, C.; Calderon-Rivera, A.; Francois-Moutal, L.; Khanna, M.; Madura, C. L.; Luo, S.; Ran, D.; Boinon, L.; Perez-Miller, S.; Moutal, A.; Khanna, R.
10.1101/2022.07.09.499431 — neuroscience — Posted on 2022-07-10
2701 In-vivo fast non-linear microscopy reveals impairment of fast axonal transport induced by molecular motor imbalances in the brain of zebrafish larvae
GRIMAUD, B.; FRETAUD, M.; TERRAS, F.; BENASSY, A.; DUROURE, K.; BERCIER, V.; TRIPPE-ALLARD, G.; MOHAMMEDI, R.; GACOIN, T.; Del Bene, F.; MARQUIER, F.; LANGEVIN, C.; TREUSSART, F.
10.1101/2022.07.09.499436 — neuroscience — Posted on 2022-07-10
2702 Longitudinal Urine Metabolic Profiling and Gestational Age Prediction in Pregnancy
Chen, S.; Shen, X.; Liang, L.; Avina, M.; Zackriah, H.; Jelliffe-Pawlowski, L.; Rand, L.; Snyder, M.
10.1101/2022.07.10.499478 — systems biology — Posted on 2022-07-10
2704 Phosphorylation of light-harvesting complex II controls excitation energy spillover between photosystems
Tokutsu, R.; Kim, E.; Akimoto, S.; Yokono, M.; Fujimura-Kamada, K.; Ohnishi, N.; Ueno, Y.; Minagawa, J.
10.1101/2022.07.10.499486 — plant biology — Posted on 2022-07-10
2707 Dynamics of Borrelia Burgdorferi Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model
Guo, Z.; Zhao, N.; Chung, T. D.; Singh, A.; Pandey, I.; Wang, L.; Gu, X.; Ademola, A.; Linville, R. M.; Pal, U.; Dumler, J. S.; Searson, P. C.
10.1101/2022.07.10.499449 — bioengineering — Posted on 2022-07-10
2708 Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury
Liss, K. H. H.; Mousa, M.; Bucha, S.; Lutkewitte, A. J.; Allegood, J.; Cowart, L. A.; Finck, B.
10.1101/2022.07.10.499482 — biochemistry — Posted on 2022-07-10
2710 Realizing the promise of biodiversity genomics with highly accurate long reads
Hotaling, S.; Wilcox, E. R.; Heckenhauer, J.; Stewart, R. J.; Frandsen, P. B.
10.1101/2022.07.10.499467 — genomics — Posted on 2022-07-10
2711 Phylogenetic resolution of the Cannabis genus reveals extensive admixture
Halpin-McCormick, A.; Heyduk, K.; Kantar, M.; Batora, N.; Masalia, R.; Law, K.; Kuntz, E.
10.1101/2022.07.09.499013 — genomics — Posted on 2022-07-10
2712 Transgenerational effects of alcohol on intoxication sensitivity in Caenorhabditis elegans
Guzman, D. M.; Chakka, K.; Shi, T.; Marron, A.; Fiorito, A. E.; Rahman, N. S.; Ro, S.; Sucich, D. G.; Pierce, J.
10.1101/2022.07.10.499458 — genetics — Posted on 2022-07-10
2713 Yeast Mitochondrial Derived Vesicles (MDVs) have membrane potential and contain a functional ATP synthase
Hazan (Ben-Menachem), R.; Lintzer, D.; Ziv, T.; Das, K.; Rosenhek-Goldian, I.; Porat, Z.; Ben Ami Pilo, H.; Karniely, S.; Saada, A.; Regev-Rudzki, N.; Pines, O.
10.1101/2022.07.10.499450 — cell biology — Posted on 2022-07-10
2716 The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses
Sharma, A.; Achi, S.; Ibeawuchi, S. R.; Anandachar, M. S.; Gementera, H.; Chaudhury, U.; Usmani, F.; Vega, K.; Sayed, I.; Das, S.
10.1101/2022.07.09.499433 — microbiology — Posted on 2022-07-10
2719 Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment
Gray, A. L.; Karlsson, R.; Roberts, A. R.; Ridley, A. J.; Pun, N.; Hughes, C.; Medina-Ruiz, L.; Birchenough, H.; Salanga, C.; Yates, E. A.; Turnbull, J. E.; Handel, T. M.; Graham, G.; Jowitt, T. A.; Schiessl, I.; Richter, R. P.; Miller, R. L.; Dyer, D. P.
10.1101/2022.07.10.499282 — immunology — Posted on 2022-07-10
2721 Effects of footshock stress on social behavior and neuronal activation in the medial prefrontal cortex and amygdala of male and female mice
Dorofeikova, M.; Borkar, C. D.; Weissmuller, K.; Smith-Osborne, L.; Basavanhalli, S.; Bean, E.; Smith, A.; Duong, A.; Resendez, A.; Fadok, J. P.
10.1101/2021.12.16.473017 — neuroscience — Posted on 2022-07-10
2724 BayesTME: A unified statistical framework for spatial transcriptomics
Zhang, H.; Hunter, M. V.; Chou, J.; Quinn, J. F.; Zhou, M.; White, R.; Tansey, W.
10.1101/2022.07.08.499377 — bioinformatics — Posted on 2022-07-10
2727 Mapping fetal myeloid differentiation in airway samples from premature neonates with single-cell profiling
Welfley, H.; Kylat, R.; Zaghloul, N.; Halonen, M.; Martinez, F. D.; Ahmed, M.; Cusanovich, D. A.
10.1101/2022.07.08.499395 — developmental biology — Posted on 2022-07-10
2731 Brain Network Architecture Constrains Age-related Cortical Thinning
Petersen, M.; Naegele, F. L.; Mayer, C.; Schell, M.; Rimmele, D. L.; Petersen, E.; Kuehn, S.; Gallinat, J.; Hanning, U.; Fiehler, J.; Twerenbold, R.; Gerloff, C.; Thomalla, G.; Cheng, B.
10.1101/2022.07.08.499363 — neuroscience — Posted on 2022-07-10
2732 CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes
Lam, M.; Takeo, K.; Almeida, R. G.; Cooper, M. H.; Wu, K.; Iyer, M.; Kantarci, H.; Zuchero, J. B.
10.1101/2022.07.08.498895 — neuroscience — Posted on 2022-07-10
2734 Molecular annotation of AOPs guides the development of the next generation mechanistic chemical safety assessment and new approach methods
Saarimaki, L. A.; Morikka, J.; Pavel, A.; Korpilahde, S.; del Giudice, G.; Federico, A.; Fratello, M.; Serra, A.; Greco, D.
10.1101/2022.07.08.499301 — pharmacology and toxicology — Posted on 2022-07-10
2735 The Bioregistry: Unifying the Identification of Biomedical Entities through an Integrative, Open, Community-driven Metaregistry
Hoyt, C. T.; Balk, M.; Callahan, T. J.; Domingo-Fernandez, D.; Haendel, M. A.; Hegde, H. B.; Himmelstein, D. S.; Karis, K.; Kunze, J.; Lubiana, T.; Matentzoglu, N.; McMurry, J.; Moxon, S.; Mungall, C. J.; Rutz, A.; Unni, D. R.; Willighagen, E.; Winston, D.; Gyori, B. M.
10.1101/2022.07.08.499378 — bioinformatics — Posted on 2022-07-10
2736 Plasmid Permissiveness of Wastewater Microbiomes can be Predicted from 16S rDNA sequences by Machine Learning
Moradigaravand, D.; Li, L.; Dechesne, A.; Nesme, J.; Ahmad, H.; Banzhaf, M.; Sorensen, S.; Smets, B.; Kreft, J.
10.1101/2022.07.09.499415 — bioinformatics — Posted on 2022-07-10
2737 Organs-on-a-Chip Database (OOCDB): A Comprehensive, Systematic and Real-time Organs-on-a-chip Database
Li, J.; Liang, W.; Chen, Z.; Li, X.; Gu, P.; Liu, A.; Chen, P.; Qiwei, L.; Mei, X.; Yang, J.; Liu, J.; Jiang, L.; Gu, Z.
10.1101/2022.07.05.498623 — bioinformatics — Posted on 2022-07-10
2745 Micropatterned Organoids Enable Modeling of the Earliest Stages of Human Cardiac Vascularization
Abilez, O. J.; Yang, H.; Tian, L.; Wilson, K. D.; Lyall, E. H.; Shen, M.; Bhoi, R.; Zhuge, Y.; Jia, F.; Wo, H. T.; Zhou, G.; Guan, Y.; Aldana, B.; Obal, D.; Peltz, G.; Zarins, C. K.; Wu, J. C.
10.1101/2022.07.08.499233 — developmental biology — Posted on 2022-07-10
2746 Cellular contributions to ictal population signals
Lau, L. A.; Zhao, Z.; Gomperts, S. N.; Staley, K. J.; Lillis, K. P.
10.1101/2022.07.08.499193 — neuroscience — Posted on 2022-07-10
2747 Corticostriatal Beta Power Changes Associated with Cognitive Function in Parkinsons Disease
Paulo, D. L.; Qian, H.; Subramanian, D.; Johnson, G. W.; Hett, K.; Kao, C.; Roy, N.; Dhima, K.; Claassen, D. O.; Bick, S. K.
10.1101/2022.07.07.499165 — neuroscience — Posted on 2022-07-10
2748 Adult neural stem cells and neurogenesis are resilient to intermittent fasting
Gabarro-Solanas, R.; Davaatseren, A.; Kepcija, T.; Crespo-Enriquez, I.; Urban, N.
10.1101/2022.07.08.499318 — neuroscience — Posted on 2022-07-10
2749 Longitudinal structural change of gray matter before and after hemispherotomy
Yu, H.; Chen, Y.; Luo, J.; Liu, Q.; Qin, P.; Wang, C.; Qu, J.; Cai, L.; Gong, G.
10.1101/2022.07.07.499164 — neuroscience — Posted on 2022-07-10
2752 TPH2 knockout male rats are aggressive, show less anxiety, and exhibit an altered oxytocin system
Meng, X.; Grandjean, J.; Sbrini, G.; Schipper, P.; Hofwijks, N.; Calabrese, F.; Homberg, J.
10.1101/2022.07.08.499134 — neuroscience — Posted on 2022-07-10
2760 Grapevine leaf size influences vine canopy temperature
Migicovsky, Z.; Swift, J. F.; Helget, Z.; Klein, L. L.; Ly, A.; Maimaitiyiming, M.; Woodhouse, K.; Fennell, A.; Kwasniewski, M.; Miller, A.; Chitwood, D. H.; Cousins, P.
10.1101/2022.07.07.499216 — plant biology — Posted on 2022-07-10
2761 Interplay between MYZUS PERSICAE-INDUCED LIPASE 1 and OPDA signaling in controlling green peach aphid infestation on Arabidopsis thaliana
Archer, L.; Mondal, H. A.; Behera, S.; Twayana, M.; Louis, J.; Nalam, V. J.; Keereetaweep, J.; Chowdhury, Z.; shah, J.
10.1101/2022.07.08.499389 — plant biology — Posted on 2022-07-10
2762 Nitrate-dependent salt tolerance mediated by OsNLP4-OsMADS27 module
Alfatih, A.; Zhang, J.; Song, Y.; Ullah Jan, S.; Zhang, Z.-S.; Xia, J.-Q.; Zhang, Z.-Y.; Nazish, T.; Wu, J.; Zhao, P.-X.; Xiang, C.
10.1101/2022.07.08.499223 — plant biology — Posted on 2022-07-10
2764 Single particle profiler for measuring properties of nano-sized bioparticles
Sych, T.; Weber, F.; Schlegel, J.; Bostancioglu, B.; Barriga, H.; Ezzat, K.; Stangl, H.; Plochberger, B.; El Andaloussi, S.; Stevens, M.; Laurencikiene, J.; Sezgin, E.
10.1101/2022.07.08.499323 — biophysics — Posted on 2022-07-10
2771 SNVformer: An Attention-based Deep Neural Network for GWAS Data
Elmes, K.; Benavides-Prado, D.; Tan, N. O.; Nguyen, T. B.; Witbrock, M.; Gavryushkin, A.
10.1101/2022.07.07.499217 — bioinformatics — Posted on 2022-07-10
2776 Bioelectronic microfluidic wound healing
Shaner, S. W.; Savelyeva, A.; Kvartuh, A.; Jedrusik, N.; Matter, L.; Leal, J.; Asplund, M.
10.1101/2022.07.08.499276 — bioengineering — Posted on 2022-07-10
2777 A translational swine model for Crohn`s disease
Winogrodzki, T.; Metwaly, A.; Grodziecki, A.; Liang, W.; Klinger, B.; Flisikowski, K.; Flisikowska, T.; Fischer, K.; Steiger, K.; Haller, D.; Schnieke, A.
10.1101/2022.07.08.499360 — bioengineering — Posted on 2022-07-10
2778 OpenCap: 3D human movement dynamics from smartphone videos
Uhlrich, S. D.; Falisse, A.; Kidzinski, Łukasz; Muccini, J.; Ko, M.; Chaudhari, A. S.; Hicks, J. L.; Delp, S. L.
10.1101/2022.07.07.499061 — bioengineering — Posted on 2022-07-10
2780 Sniff Olfactometer (SO) Protocols
Ni, J. L.; Tang, Q.; Huang, J. D.; Solla, A. L.; Kelson, H.; Weeks, M. D.; Alcott, Z. M.-L.; Ong, J. M.; Gomez, A.; Ding, K.; Acree, T. E.
10.1101/2022.07.08.499357 — animal behavior and cognition — Posted on 2022-07-10
2784 Ethanol Exposure Perturbs Sea Urchin Development and Disrupts Developmental Timing
Rodriguez-Sastre, N.; Shapiro, N.; Hawkins, D. Y.; Lion, A. T.; Peyreau, M.; Correa, A. E.; Dionne, K.; Bradham, C.
10.1101/2022.07.07.499183 — developmental biology — Posted on 2022-07-10
2785 Oscillatory mechanisms of intrinsic brain networks
Luo, Y.; Meng, X.; Zhou, G.; Zhou, J.; Zelano, C. M.; Li, Y.; Xu, J.; Deng, G.; Luo, Y.-j.; Ai, H.; Xu, P.; Chen, F.
10.1101/2022.07.07.499235 — neuroscience — Posted on 2022-07-10
2787 Cohort-mean measured macromolecules lead to more robust linear-combination modeling than subject-specific or parameterized ones
Zöllner, H. J.; Davies-Jenkins, C. W.; Murali-Manohar, S.; Gong, T.; Song, Y.; Hui, S. C. N.; Chen, W.; Wang, G.; Edden, R. A. E.; Oeltzschner, G.
10.1101/2022.07.07.499181 — neuroscience — Posted on 2022-07-10
2789 A neural substrate of sex-dependent modulation of motivation by value
Cox, J. M.; Minerva, A. R.; Fleming, W.; Zimmerman, C. A.; Hayes, C.; Zorowitz, S.; Bandi, A.; Ornelas, S.; McMannon, B.; Parker, N. F.; Witten, I. B.
10.1101/2022.07.07.499209 — neuroscience — Posted on 2022-07-10
2793 Mesoscale cortex-wide neural dynamics predict self-initiated actions in mice several seconds prior to movement
Mitelut, C.; Zhang, Y.; Sekino, Y.; Boyd, J.; Bolanos, F.; Swindale, N. V.; Silasi, G.; Saxena, S.; Murphy, T. H.
10.1101/2021.12.17.473193 — neuroscience — Posted on 2022-07-10
2800 Growth rate as a modulator of tooth patterning during adaptive radiations
Sadier, A.; Anthwal, N.; Krause, A.; Dessalles, R.; Lake, M.; Bentolila, L.; Haase, R.; Nieves, N.; Santana, S.; Sears, K. E.
10.1101/2021.12.05.471324 — evolutionary biology — Posted on 2022-07-10
2801 Long wavelength light reduces the negative consequences of dim light at night in the Cntnap2 mouse model of autism.
Wang, H.-B.; Zhou, D.; Luk, S. H. C.; Cha, H. I.; Mac, A.; Chae, R.; Matynia, A.; Harrison, B.; Afshari, S.; Block, G. D.; Ghiani, C. A.; Colwell, C. S.
10.1101/2022.06.09.494760 — neuroscience — Posted on 2022-07-10
2802 An Integrated Model for Predicting KRAS Dependency
Tsai, Y.; Chareddy, Y.; Price, B.; Parker, J.; Pecot, C. V.
10.1101/2022.07.07.499238 — bioinformatics — Posted on 2022-07-10
2806 Alternative splicing and circRNA biogenesis driven by alpha and gamma herpesviruses
Dremel, S. E.; Koparde, V. N.; Arbuckle, J. H.; Kristie, T. M.; Krug, L. T.; Conrad, N. K.; Ziegelbauer, J. M.
10.1101/2022.07.08.499347 — microbiology — Posted on 2022-07-10
2807 Development of genome-driven, lifestyle-informed primers for identification of the cereal infecting pathogens Xanthomonas translucens pathovars undulosa and translucens.
Roman-Reyna, V.; Curland, R. D.; Velez-Negron, Y.; Ledman, K. E.; Gutierrez, D.; Beutler, J.; Butchacas, J.; Brar, G. S.; Roberts, R.; Dill-Macky, R.; Jacobs, J. M.
10.1101/2022.07.09.499425 — microbiology — Posted on 2022-07-10
2808 Swapped genetic code blocks viral infections and gene transfer
Nyerges, A.; Vinke, S.; Flynn, R.; Owen, S. V.; Rand, E. A.; Budnik, B.; Keen, E.; Narasimhan, K.; Marchand, J. A.; Baas-Thomas, M.; Liu, M.; Chen, K.; Chiappino-Pepe, A.; Hu, F.; Baym, M.; Church, G. M.
10.1101/2022.07.08.499367 — synthetic biology — Posted on 2022-07-10
2812 Discovery of a monomeric green fluorescent protein sensor for chloride by structure-guided bioinformatics
Peng, W.; Maydew, C.; Kam, H.; Lynd, J.; Tutol, J. N.; Phelps, S. M.; Abeyrathna, S.; Meloni, G.; Dodani, S. C.
10.1101/2022.07.08.499230 — biochemistry — Posted on 2022-07-09
2814 High-resolution characterisation of short-term temporal variability in the taxonomic and resistome composition of wastewater influent
Chau, K. K.; Goodall, T.; Bowes, M.; Easterbrook, K.; Brett, H.; Hughes, J.; Crook, D. W.; Read, D. S.; Walker, A. S.; Stoesser, N.
10.1101/2022.07.08.499324 — genomics — Posted on 2022-07-09
2815 Evaluating limitations of quantitative metagenomics with synthetic dsDNA and ssDNA standards
Langenfeld, K.; Hegarty, B.; Vidaurri, S.; Crossette, E.; Duhaime, M. B.; Wigginton, K.
10.1101/2022.07.08.499345 — genomics — Posted on 2022-07-10
2820 Control of PHYTOCHROME KINASE SUBSTRATE subcellular localization and biological activity by protein S-acylation
Lopez Vazquez, A.; Allenbach Petrolati, L.; Dessimoz, C.; Lampugnani, E. R.; Glover, N.; Fankhauser, C.
10.1101/2022.07.08.499325 — plant biology — Posted on 2022-07-09
2823 Proteomic profile of nuclei containing p62-positive inclusions in neuronal intranuclear inclusion disease
Kurihara, M.; Mano, T.; Eto, F.; Yao, I.; Sato, K.; Ohtomo, G.; Bannai, T.; Shibata, S.; Ishiura, H.; Ikemura, M.; Matsubara, T.; Morishima, M.; Saito, Y.; Murayama, S.; Toda, T.; Setou, M.; Iwata, A.
10.1101/2022.07.08.499227 — biochemistry — Posted on 2022-07-09
2824 Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control
Nadler, F.; Lavdovskaia, E.; Krempler, A.; Cruz-Zaragoza, L. D.; Dennerlein, S.; Richter-Dennerlein, R.
10.1101/2022.07.08.499411 — biochemistry — Posted on 2022-07-09
2825 A manually curated annotation characterises genomic features of P. falciparum lncRNAs
Hoshizaki, J.; Adjalley, S.; Thathy, V.; Judge, K.; Berriman, M.; Reid, A. J.; Lee, M. C. S.
10.1101/2022.07.08.499349 — genomics — Posted on 2022-07-09
2827 Accurate simultaneous sequencing of genetic and epigenetic bases in DNA
Fullgrabe, J.; Gosal, W. S.; Creed, P.; Liu, S.; Lumby, C. K.; Morley, D. J.; Ost, T. W. B.; Vilella, A. J.; Yu, S.; Bignell, H.; Burns, P.; Charlesworth, T.; Hodson, C.; Fu, B.; Fordham, H.; Harding, N.; Golder, P.; Li, M.; Lila, M.; Liu, Y.; M, J.; Monahan, J.; Nentwich, O.; Palmer, A.; Steward, M.; Taipale, M.; Vandomme, A.; Singhal, A.; Vivian, J.; Wojtowicz, N.; Williams, N.; Walker, N. J.; Wong, N. C. H.; Yalloway, G.; Holbrook, J. D.; Balasubramanian, S.
10.1101/2022.07.08.499285 — genomics — Posted on 2022-07-09
2828 Development of Polymer/DNA Polyplexes System for Nucleic Acid Delivery to the Multicellular Organism C. elegans
Yenisert, F.; Bayram, N. N.; Koseoglu, B.; Topuzogullari, M.; Dincer Isoglu, S.; Kaplan, O. I.
10.1101/2022.07.08.499239 — genetics — Posted on 2022-07-09
2830 Virus Infection Causes Intestinal Dysbiosis to Promote Type 1 Diabetes Onset
Morse, Z. J.; Simister, R. L.; Crowe, S. A.; Horwitz, M. S.; Osborne, L. C.
10.1101/2022.07.08.499212 — microbiology — Posted on 2022-07-09
2831 A single residue within the MCR-1 protein confers anticipatory resilience
Frantz, R.; Gwozdzinski, K.; Gisch, N.; Doijad, S. P.; Hudel, M.; Wille, M.; Mraheil, M. A.; Schwudke, D.; Imirzalioglu, C.; Falgenhauer, L.; Ehrmann, M.; Chakraborty, T.
10.1101/2022.07.08.499312 — microbiology — Posted on 2022-07-09
2832 The age of reason: Functional brain network development during childhood
Tooley, U. A.; Park, A. T.; Leonard, J. A.; Boroshok, A. L.; McDermott, C. L.; Tisdall, D.; Bassett, D. S.; Mackey, A. P.
10.1101/2022.07.07.499176 — neuroscience — Posted on 2022-07-09
2834 A Draft Human Pangenome Reference
Liao, W.-W.; Asri, M.; Ebler, J.; Doerr, D.; Haukness, M.; Hickey, G.; Lu, S.; Lucas, J. K.; Monlong, J.; Abel, H. J.; Buonaiuto, S.; Chang, X. H.; Cheng, H.; Chu, J.; Colonna, V.; Eizenga, J. M.; Feng, X.; Fischer, C.; Fulton, R. S.; Garg, S.; Groza, C.; Guarracino, A.; Harvey, W. T.; Heumos, S.; Howe, K.; Jain, M.; Lu, T.-Y.; Markello, C.; Martin, F. J.; Mitchell, M. W.; Munson, K. M.; Mwaniki, M. N.; Novak, A. M.; Olsen, H. E.; Pesout, T.; Porubsky, D.; Prins, P.; Sibbesen, J. A.; Tomlinson, C.; Villani, F.; Vollger, M. R.; Human Pangenome Reference Consortium, ; Bourque, G.; Chaisson, M.
10.1101/2022.07.09.499321 — genomics — Posted on 2022-07-09
2835 Testing Human Anxiety Associations of Genes Previously Implicated by Mouse Anxiety Models
Brasher, M. S.; Mize, T. J.; Thomas, A. L.; Hoeffer, C. A.; Ehringer, M. A.; Evans, L. M.
10.1101/2022.07.08.499186 — genetics — Posted on 2022-07-09
2836 Retaining pluripotency and exogenous mRNA introduction in planarian stem cell culture
Lei, K.; Zhang, W.; Chen, J.; McKinney, S. A.; Ross, E. J.; Lee, H.-C.; Sanchez Alvarado, A.
10.1101/573725 — cell biology — Posted on 2022-07-09
2837 Pathway-specific inputs to the superior colliculus support flexible triggering of innate behaviors
Li, C.; Kuhn, N. K.; Alkislar, I.; Sans Dublanc, A.; Zemmouri, F.; Paesmans, S.; Reinhard, K.; Farrow, K.
10.1101/2022.07.08.499294 — neuroscience — Posted on 2022-07-09
2841 ppGpp and RNA-Polymerase Backtracking Guide Antibiotic-Induced Mutable Gambler Cells
Zhai, Y.; Minnick, P. J.; Pribis, J. P.; Garcia-Villada, L.; Hastings, P. J.; Herman, C.; Rosenberg, S. M.
10.1101/2022.07.06.499071 — microbiology — Posted on 2022-07-09
2842 enclone: precision clonotyping and analysis of immune receptors
Jaffe, D. B.; Shahi, P.; Adams, B. A.; Chrisman, A. M.; Finnegan, P. M.; Raman, N.; Royall, A. E.; Tsai, F.; Vollbrecht, T.; Reyes, D. S.; McDonnell, W. J.
10.1101/2022.04.21.489084 — immunology — Posted on 2022-07-09
2844 Reactivating Hippocampal-Mediated Memories During Reconsolidation to Disrupt Fear
Grella, S. L.; Fortin, A. H.; Bladon, J. H.; Reynolds, L. F.; Ruesch, E.; Gross, A.; Shpokayte, M.; Cincotta, C.; Zaki, Y.; Ramirez, S.
10.1101/2021.09.16.460695 — neuroscience — Posted on 2022-07-09
2845 β-catenin activity induces an RNA biosynthesis program promoting therapy resistance in T Acute Lymphoblastic Leukemia
Garcia-Hernandez, V.; Arambilet, D.; Guillen, Y.; Lobo, T.; Gekas, C.; Vega-Garcia, N.; Sentis, I.; Trincado, J. L.; Marquez-Lopez, I.; Heyn, H.; Camos, M.; Espinosa, L.; Bigas, A.
10.1101/2022.07.07.499249 — cancer biology — Posted on 2022-07-09
2846 Building pyramids against the evolutionary emergence of pathogens
Gandon, S.; Guillemet, M.; Gatchitch, F.; Nicot, A.; Renaud, A. C.; Tremblay, D. M.; Moineau, S.
10.1101/2022.07.07.499135 — evolutionary biology — Posted on 2022-07-09
2847 The LH-DH module of the bacterial replicative helicases is the common binding site for DciA and other helicase loaders
Cargemel, C.; Marsin, S.; Noiray, M.; Legrand, P.; Bounoua, H.; Li de la Sierra-Gallay, I.; Walbott, H.; Quevillon-Cheruel, S.
10.1101/2022.07.08.499335 — molecular biology — Posted on 2022-07-09
2852 Transcriptional drifts associated with environmental changes in endothelial cells
Afshar, Y.; Ma, F.; Quach, A.; Jeong, A.; Sunshine, H.; Freitas, V.; Jami-Alahmadi, Y.; Li, X.; Pellegrini, M.; Wohlschlegel, J. A.; Romanoski, C. E.; Iruela-Arispe, L.
10.1101/2022.07.08.499287 — cell biology — Posted on 2022-07-09
2857 A rigidity phase transition of Stomatin condensates governs a switch from transport to mechanotransduction
Sanfeliu-Cerdan, N.; Mateos, B.; Garcia-Cabau, C.; Catala-Castro, F.; Ribera, M.; Ruider, I.; Porta-de-la-Riva, M.; Wieser, S.; Salvatella, X.; Krieg, M.
10.1101/2022.07.08.499356 — cell biology — Posted on 2022-07-09
2858 Mitoguardin-2 is a lipid transporter and its lipid transfer ability is required for function
Hong, Z.; Adlakha, J.; Guinn, E.; Giska, F.; Gupta, K.; Melia, T.; Reinisch, K. M.
10.1101/2022.07.08.499339 — cell biology — Posted on 2022-07-09
2859 Multisensory learning binds modality-specific neurons into a cross-modal memory engram
Waddell, S.; Okray, Z.; Jacob, P. F.; Stern, C.; Desmond, K.; Otto, N.; Vargas-Gutierrez, P.
10.1101/2022.07.08.499174 — neuroscience — Posted on 2022-07-09
2861 Alzheimer disease risk gene BIN1 modulates neural network activity through the regulation of L-type calcium channel expression in human induced neurons
Saha, O.; Melo de Farias, A. R.; Pelletier, A.; Siedlecki-Wullich, D.; Gadaut, J.; Landeira, B. M. S.; Carrier, A.; Vreulx, A.-C.; Guyot, K.; Bonnefond, A.; Amouyel, P.; Queiroz, C. M.; Kilinc, D.; Delahaye, F.; Lambert, J.-C.; Costa, M. R.
10.1101/2022.01.18.476601 — neuroscience — Posted on 2022-07-09
2862 Three-dimensional visualization of moss rhizoid system by refraction-contrast X-ray micro-computed tomography
Yamaura, R.; Tamaoki, D.; Kamachi, H.; Yamauchi, D.; Mineyuki, Y.; Uesugi, K.; Hoshino, M.; Suzuki, T.; Shimazu, T.; Kasahara, H.; Kamada, M.; Hanba, Y.; Kume, A.; Fujita, T.; Karahara, I.
10.1101/2022.07.07.499130 — plant biology — Posted on 2022-07-09
2864 An Ecological Approach to the Effects of Water-Source Locations and Time-Based Schedules on Entropy and Spatio-Temporal Behavioral Features
Hernandez-Eslava, V.; Leon, A.; Guzman, I.; Diaz, F.; Avendano-Garrido, M. L.; Toledo, P.; Hernandez-Linares, C. A.; Luna, I.
10.1101/2021.07.15.452514 — animal behavior and cognition — Posted on 2022-07-09
2866 Gene expression analysis of the Xenopus laevis early limb bud proximodistal axis.
Hudson, D. T.; Bromell, J. S.; Day, R. C.; McInnes, T.; Ward, J. M.; Beck, C. W.
10.1101/2022.05.03.490399 — developmental biology — Posted on 2022-07-09
2868 Deciphering the conformations and dynamics of FG-nucleoporins in situ
Yu, M.; Heidari, M.; Mikhaleva, S.; Tan, P. S.; Mingu, S.; Hao, R.; Reinkermeier, C. D.; Obarska-Kosinska, A.; Siggel, M.; Beck, M.; Hummer, G.; Lemke, E. A.
10.1101/2022.07.07.499201 — biophysics — Posted on 2022-07-08
2869 Integrative solution structure of a PTBP1-viral IRES complex reveals strong compaction and ordering with residual conformational flexibility
Dorn, G.; Gmeiner, C.; de Vries, T.; Dedic, E.; Novakovic, M.; Damberger, F. F.; Maris, C.; Finol, E.; Sarnowski, C. P.; Kolhbrecher, J.; Welsh, T. J.; Bolisetty, S.; Mezzenga, R.; Aebersold, R.; Leitner, A.; Yulikov, M.; Jeschke, G.; Allain, F. H.- T.
10.1101/2022.07.08.498958 — biochemistry — Posted on 2022-07-08
2870 A molecular phenotypic map of Malignant Pleural Mesothelioma
Di Genova, A.; Mangiante, L.; Sexton-Oates, A.; Voegele, C.; Fernandez-Cuesta, L.; Alcala, N.; Foll, M.
10.1101/2022.07.06.499003 — genomics — Posted on 2022-07-08
2873 Increased mitochondrial Ca2+ contributes to health decline with age and Duchene muscular dystrophy in C. elegans.
Higashitani, A.; Teranishi, M.; Nakagawa, Y.; Itoh, Y.; Sudevan, S.; Szewczyk, N. J.; Kubota, Y.; Abe, T.; Kobayashi, T.
10.1101/2022.07.08.499319 — cell biology — Posted on 2022-07-08
2874 IL11 stimulates IL33 expression and proinflammatory fibroblast activation
Widjaja, A. A.; Chothani, S.; Viswanathan, S.; Goh, J. W. T.; Lim, W.-W.; Cook, S. A.
10.1101/2022.07.08.499236 — molecular biology — Posted on 2022-07-08
2878 Transient T cell expansion, activation, and proliferation in therapeutically vaccinated SIV+ macaques treated with N-803
Harwood, O. E.; Balgeman, A. J.; Weaver, A. J.; Ellis-Connell, A. L.; Weiler, A. M.; Erickson, K. N.; Matschke, L. M.; Golfinos, A. E.; Vezys, V.; Skinner, P. J.; Safrit, J. T.; Edlefsen, P. T.; Reynolds, M. R.; Friedrich, T. C.; O'Connor, S. L.
10.1101/2022.07.08.499199 — immunology — Posted on 2022-07-08
2879 Interleukin-1α and Leukemia Inhibitory Factor Promote Extramedullary Hematopoiesis
Barisas, D.; Kim, M.; Subramanian, M.; Kabir, A. U.; Krchma, K.; Wu, J.; Zinselmeyer, B.; Stewart, C.; Choi, K.
10.1101/2022.07.07.499256 — immunology — Posted on 2022-07-08
2880 PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma
Corrales, E.; Levit-Zerdoun, E.; Metzger, P.; Mertes, R.; Lehmann, A.; Muench, J.; Lemke, S.; Kowar, S.; Boerries, M.
10.1101/2022.07.08.499090 — cancer biology — Posted on 2022-07-08
2881 Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+ myeloid cells into the tumor microenvironment in a redundant manner
Takacs, G. P.; Kreiger, C. J.; Luo, D.; Tian, G.; Garcia, J. S.; Deleyrolle, L. P.; Mitchell, D. A.; Harrison, J. K.
10.1101/2022.07.08.499173 — cancer biology — Posted on 2022-07-08
2883 Single Cell RNA Sequencing Driven Characterization of Pediatric Mixed Phenotype Acute Leukemia
Mumme, H. L.; Raikar, S. S.; Bhasin, S. S.; Thomas, B. E.; DeRyckere, D.; Wechsler, D. S.; Porter, C. C.; Castellino, S. M.; Graham, D. K.; Bhasin, M. K.
10.1101/2022.07.07.499210 — genomics — Posted on 2022-07-08
2884 Gene-by-gene screen of the unknown proteins encoded on P. falciparum chromosome 3
Kimmel, J.; Schmitt, M.; Sinner, A.; Jansen, P.; Ramon-Zamorano, G.; Mainye, S.; Toenhake, C. G.; Wichers, J. S.; Cronshagen, J.; Sabitzki, R.; Mesen-Ramirez, P.; Behrens, H. M.; Bartfai, R.; Spielmann, T.
10.1101/2022.07.07.499005 — cell biology — Posted on 2022-07-08
2888 Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort
Nishijima, S.; Nagata, N.; Kiguchi, Y.; Kojima, Y.; Miyoshi-Akiyama, T.; Kimura, M.; Ohsugi, M.; Ueki, K.; Oka, S.; Mizokami, M.; Itoi, T.; Kawai, T.; Uemura, N.; Hattori, M.
10.1101/2022.07.08.498934 — microbiology — Posted on 2022-07-08
2889 Looking for a needle in a haystack: magnetotactic bacteria help in "rare biosphere" investigations
Uzun, M.; Koziaeva, V.; Dziuba, M.; Alekseeva, L.; Krutkina, M.; Sukhacheva, M.; Baslerov, R.; Grouzdev, D.
10.1101/2022.07.08.499144 — microbiology — Posted on 2022-07-08
2890 A fungal secondary metabolism gene cluster enables mutualist-pathogen transition in root endophyte Colletotrichum tofieldiae
Hiruma, K.; Aoki, S.; Utami, Y. D.; Okamoto, M.; Kawamura, N.; Nakamura, M.; Ohmori, Y.; Sugita, R.; Tanoi, K.; Sato, T.; Iwasaki, W.; Saijo, Y.
10.1101/2022.07.07.499222 — microbiology — Posted on 2022-07-08
2891 Faecal carriage of ESBL-producing Escherichia coli in a remote region of Niger
Jacquier, H.; Assao, B.; Chau, F.; Guindo, O.; Condamine, B.; Magnan, M.; Bridier-Nahmias, A.; Sayingoza-Makombe, N.; Moumouni, A.; Page, A.-L.; Langendorf, C.; Coldiron, M.; Denamur, E.; de Lastours, V.
10.1101/2022.07.07.499258 — microbiology — Posted on 2022-07-08
2892 Building an Open Representation for Biological Protocols
Bartley, B.; Beal, J.; Rogers, M.; Bryce, D.; Goldman, R. P.; Keller, B.; Lee, P.; Biggers, V.; Nowak, J.; Weston, M.
10.1101/2022.07.05.498808 — synthetic biology — Posted on 2022-07-08
2895 Carbohydrate-Binding Protein from Stinging Nettle as Fusion Inhibitor for SARS-CoV-2 Variants of Concern
Vanhulle, E.; D'huys, T.; Provinciael, B.; Stroobants, J.; Camps, A.; Noppen, S.; Schols, D.; Van Damme, E. J. M.; Maes, P.; Stevaert, A.; Vermeire, K.
10.1101/2022.07.08.499297 — microbiology — Posted on 2022-07-08
2897 Correlation of Alpha-1 Antitrypsin Levels and Exosome Associated Neutrophil Elastase Endothelial Injury in Subjects with SARS-CoV2 Infection
Lascano, J.; Oshins, R.; Eagan, C.; Wadood, Z.; qiang, x.; Flagg, T.; Scindia, Y.; Mehrad, B.; Brantly, M.; Khodayari, N.
10.1101/2022.07.07.499204 — cell biology — Posted on 2022-07-08
2898 ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells
Panneton, V.; Mindt, B. C.; Bouklouch, Y.; Bouchard, A.; Mohammaei, S.; Chang, J.; Witalis, M.; Li, J.; Stancescu, A.; Bradley, J. E.; Randall, T. D.; Fritz, J. H.; Suh, W.-K.
10.1101/2021.09.14.460384 — immunology — Posted on 2022-07-08
2900 Accurate and efficient protein sequence design through learning concise local environment of residues
Huang, B.; Fan, T.; Wang, K.; Zhang, H.; Yu, C.; Nie, S.; Qi, Y.; Zheng, W.-M.; Han, J.; Fan, Z.; Sun, S.; Ye, S.; Yang, H.; Bu, D.
10.1101/2022.06.25.497605 — bioinformatics — Posted on 2022-07-08
2901 Stable twin rDNA loci form a single nucleolus in brewer's yeast
Stefanita, L. L.; Luo, J.; Haase, M. A. B.; Zhang, W.; Boeke, J.
10.1101/2022.06.14.496147 — genomics — Posted on 2022-07-08
2902 Human platelet lysate derived extracellular vesicles enhance angiogenesis through miR-126
De Falco, E.; Bordin, A.; Chirivi, M.; Pagano, F.; Milan, M.; Iuliano, M.; Scaccia, E.; Fortunato, O.; Mangino, G.; Dhori, X.; De Marinis, E.; D'Amico, A.; Miglietta, S.; Picchio, V.; Rizzi, R.; Romeo, G.; Pulcinelli, F.; Chimenti, I.; Frati, G.
10.1101/2022.05.10.491341 — cell biology — Posted on 2022-07-08
2903 Dendrite architecture determines mitochondrial distribution patterns in vivo
Donovan, E. J.; Agrawal, A.; Liberman, N.; Kalai, J.; Chua, J. N.; Koslover, E. F.; Barnhart, E. L.
10.1101/2022.07.01.497972 — cell biology — Posted on 2022-07-08
2904 Architecture and dynamics of a novel desmosome-endoplasmic reticulum organelle
Bharathan, N. K.; Giang, W.; Aaron, J. S.; Khuon, S.; Chew, T.-L.; Preibisch, S.; Trautman, E. T.; Heinrich, L.; Bogovic, J.; Bennett, D.; Ackerman, D.; Park, W.; Petruncio, A.; Weigel, A. V.; Saalfeld, S.; COSEM Project Team, ; Vogl, A. W.; Stahley, S. N.; Kowalczyk, A. P.
10.1101/2022.07.07.499185 — cell biology — Posted on 2022-07-08
2905 Increased structural connectivity in high schizotypy
Messaritaki, E.; Foley, S.; Barawi, K.; Ettinger, U.; Jones, D. K.
10.1101/2022.05.12.491533 — neuroscience — Posted on 2022-07-08
2907 Cancer subclone detection based on DNA copy number in single cell and spatial omic sequencing data
Wu, C.-Y.; Sathe, A.; Rong, J.; Hess, P. R.; Lau, B.; Grimes, S. M.; Ji, H. P.; Zhang, N. R.
10.1101/2022.07.05.498882 — bioinformatics — Posted on 2022-07-08
2911 Towards a mesoscale physical modeling framework for stereotactic-EEG recordings
Mercadal, B.; Lopez-Sola, E.; Galan-Gadea, A.; Al Harrach, M.; Sanchez, R.; Salvador, R.; Bartolomei, F.; Wendling, F.; Ruffini, G.
10.1101/2022.07.06.498826 — neuroscience — Posted on 2022-07-08
2913 Object-centered population coding in CA1 of the hippocampus
Nagelhus, A.; Andersson, S.; Cogno, S. G.; Moser, E. I.; Moser, M.-B.
10.1101/2022.07.07.499197 — neuroscience — Posted on 2022-07-08
2917 Periostin+ stromal cells guide lymphovascular invasion by cancer cells
Null, J. L.; Kim, D. J.; McCann, J. V.; Pramoonjago, P.; Fox, J. W.; Kumar, P.; Edatt, L.; Pecot, C. V.; Dudley, A. C.
10.1101/2022.05.19.492742 — cancer biology — Posted on 2022-07-07
2918 Fascin1 accelerates serrated pathway carcinogenesis by remodeling adherens junctions and restoring Wnt signaling.
Esmaeilniakooshkghazi, A.; Pham, E.; George, S. P.; Ahrorov, A.; Villagomez, F. R.; Byington, M.; Mukhopadhyay, S.; Patnaik, S.; Conrad, J. C.; Naik, M.; Ravi, S.; Tebbuttt, N.; Mooi, J.; Reehorst, C. M.; Mariadason, J. M.; Khurana, S.
10.1101/2022.06.14.496198 — cancer biology — Posted on 2022-07-07
2919 Multimodal Prediction of Breast Cancer Recurrence Assays and Risk of Recurrence
Howard, F. M.; Dolezal, J.; Kochanny, S.; Khramtsova, G.; Vickery, J.; Srisuwananukorn, A.; Woodard, A.; Chen, N.; Nanda, R.; Perou, C. M.; Olopade, O. I.; Huo, D.; Pearson, A. T.
10.1101/2022.07.07.499039 — cancer biology — Posted on 2022-07-08
2920 Deep Phosphoproteomic Elucidation of Metformin-Signaling in Heterogenous Colorectal Cancer Cells
Salovska, B.; Gao, E.; Mueller-Dott, S.; Li, W.; Dugourd, A.; Rosenberger, G.; Saez-Rodriguez, J.; Liu, Y.
10.1101/2022.07.07.499038 — cancer biology — Posted on 2022-07-08
2922 A deep learning approach for improved detection of homologous recombination deficiency from shallow genomic profiles
Andre, G.; Coletta, T.; Pozzorini, C.; Marques, A. C.; Bieler, J.; Kempfer, R.; Chong, C.; Saitta, A.; Smith, E.; Macheret, M.; Janiszewski, A.; Bonilla, X.; Bonet, J.; Santos-Silva, H.; Postl, M.; Wozelka-Oltjan, L.; Arrigo, N.; Willig, A.; Grimm, C.; Mullauer, L.; Xu, Z.
10.1101/2022.07.06.498851 — cancer biology — Posted on 2022-07-08
2924 Autophagy degrades myelin proteins and is essential for maintaining CNS myelin homeostasis
Ktena, N.; Kaplanis, S. I.; Kolotuev, I.; Georgilis, A.; Stavroulaki, V.; Kallergi, E.; Nikoletopoulou, V.; Karagogeos, D.; Savvaki, M.
10.1101/2022.06.20.496817 — neuroscience — Posted on 2022-07-08
2926 Using colony size to measure fitness in Saccharomyces cerevisiae
Miller, J. H.; Fasanello, V. J.; Liu, P.; Longan, E. R.; Botero, C. A.; Fay, J. C.
10.1101/2022.07.07.499129 — evolutionary biology — Posted on 2022-07-08
2928 Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting
Wei, J.; Lotfy, P.; Faizi, K.; Wang, E.; Slabodkin, H.; Kinnaman, E.; Chandrasekaran, S.; Kitano, H.; Durrant, M. G.; Duffy, C. V.; Hsu, P. D.; Konermann, S.
10.1101/2021.09.14.460134 — bioengineering — Posted on 2022-07-08
2929 Structural Characterisation of Nanoparticle-Supported Lipid Bilayers by Grazing Incidence X-ray and Neutron Scattering
Paracini, N.; Gutfreund, P.; Welbourn, R.; Gonzales, J. F.; Zhu, K.; Miao, Y.; Nageshwar, Y.; Darwish, T. A.; Garvey, C.; Waldie, S.; Larsson, J.; Wolff, M.; Cardenas, M.
10.1101/2022.07.07.499146 — biophysics — Posted on 2022-07-08
2930 Aromatic ring flips in differently packed protein crystals: MAS NMR and MD studies of 3 ubiquitin lattices
Gauto, D. F.; Lebedenko, O. O.; Becker, L. M.; Ayala, I.; Lichtenecker, R.; Skrynnikov, N. R.; Schanda, P.
10.1101/2022.07.07.499110 — biophysics — Posted on 2022-07-08
2931 RNA polymerase II and PARP1 shape enhancer-promoter contacts
Barshad, G.; Lewis, J. J.; Chivu, A. G.; Abuhashem, A.; Krietenstein, N.; Rice, E. J.; Rando, O. J.; Hadjantonakis, A.-K.; Danko, C. G.
10.1101/2022.07.07.499190 — genomics — Posted on 2022-07-08
2933 Chromosome-level genome assembly and annotation of two lineages of the ant Cataglyphis hispanica: stepping stones towards genomic studies of hybridogenesis and thermal adaptation in desert ants
Darras, H.; de Souza Araujo, N.; Baudry, L.; Guiglielmoni, N.; Lorite, P.; Marbouty, M.; Rodriguez, F.; Arkhipova, I.; Koszul, R.; Flot, J.-F.; Aron, S.
10.1101/2022.01.07.475286 — genomics — Posted on 2022-07-08
2936 The genomic landscape of contemporary western Remote Oceanians
Arauna, L. R.; Bergstedt, J.; Choin, J.; Mendoza-Revilla, J.; Harmant, C.; Roux, M.; Mas-Sandoval, A.; Lemee, L.; Colleran, H.; Francois, A.; Valentin, F.; Cassar, O.; Gessain, A.; Quintana-Murci, L.; Patin, E.
10.1101/2022.01.10.475623 — genomics — Posted on 2022-07-08
2938 Pseudouridine-dependent ribosome biogenesis regulates translation of polyglutamine proteins during Drosophila oogenesis
Breznak, S.; Peng, Y.; Deng, L.; Kotb, N. M.; Flamholz, Z.; Rapisarda, I. T.; Martin, E. T.; LaBarge, K. A.; Fabris, D.; Gavis, E. R.; Rangan, P.
10.1101/2022.07.07.499147 — developmental biology — Posted on 2022-07-08
2939 Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency
Khodayari, N.; Oshins, R.; Mehrad, B.; Lascano, J.; qiang, x.; West, J.; Holliday, S.; Wiesemann, G.; Eydgahi, S.; Brantly, M.
10.1101/2022.07.07.499205 — cell biology — Posted on 2022-07-08
2940 Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice
Geraghty, T.; Obeidat, A.; Ishihara, S.; Wood, M. J.; Li, J.; Lopes, E. B. P.; Scanzello, C. R.; Griffin, T. M.; Malfait, A.-M.; Miller, R. E.
10.1101/2022.07.07.499172 — cell biology — Posted on 2022-07-08
2942 ICAT: A Novel Algorithm to Robustly Identify Cell States Following Perturbations in Single Cell Transcriptomes
Hawkins, D. Y.; Zuch, D. T.; Huth, J.; Rodriguez-Sastre, N. C.; McCutcheon, K. R.; Glick, A.; Lion, A. T.; Thomas, C. F.; Descoteaux, A.; Johnson, W. E.; Bradham, C.
10.1101/2022.05.26.493603 — bioinformatics — Posted on 2022-07-08
2951 Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method
Mills, C. E.; Subramanian, K.; Hafner, M.; Niepel, M.; Gerosa, L.; Chung, M.; Victor, C.; Gaudio, B.; Yapp, C.; Nirmal, A. J.; Clark, N.; Sorger, P. K.
10.1101/2021.08.27.457854 — systems biology — Posted on 2022-07-08
2952 A novel RHH family transcription factor aCcr1 and its viral homologs dictate cell cycle progression in archaea
Yang, Y.; Liu, J.; Fu, X.; Zhou, F.; Zhang, S.; Zhang, X.; Huang, Q.; Krupovic, M.; She, Q.; Ni, J.; Shen, Y.
10.1101/2022.07.07.499082 — microbiology — Posted on 2022-07-08
2953 Cobalamin riboswitches are broadly sensitive to corrinoid cofactors to enable an efficient gene regulatory strategy
Kennedy, K. J.; Widner, F. J.; Sokolovskaya, O. M.; Innocent, V. L.; Procknow, R. R.; Mok, K. C.; Taga, M. E.
10.1101/2022.02.20.481237 — microbiology — Posted on 2022-07-08
2955 Rescue of alveolar wall liquid secretion blocks fatal lung injury by influenza-staphylococcal coinfection
Tang, S.; De Jesus, A. C.; Chavez, D.; Suthakaran, S.; Moore, S. K. L.; Rathnasinghe, R.; Schotsaert, M.; Bhattacharya, J.; Hook, J. L.
10.1101/2022.07.07.499169 — physiology — Posted on 2022-07-08
2957 Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach
Mensah, J. A.; Johnson, K.; Reilly, C. A.; Wilcox, K. S.; Rower, J. E.; Metcalf, C. S.
10.1101/2022.07.07.499055 — neuroscience — Posted on 2022-07-08
2959 Emotional Vocalizations Alter Behaviors and Neurochemical Release into the Amygdala
Ghasemahmad, Z.; Mrvelj, A.; Panditi, R.; Sharma, B.; Perumal, K. D.; Wenstrup, J. J.
10.1101/2022.07.02.498564 — neuroscience — Posted on 2022-07-08
2960 Local Shape Descriptors for Neuron Segmentation
Sheridan, A.; Nguyen, T.; Deb, D.; Lee, W.-C. A.; Saalfeld, S.; Turaga, S.; Manor, U.; Funke, J.
10.1101/2021.01.18.427039 — neuroscience — Posted on 2022-07-08
2962 A 96-WELL VALVED MICROFLUIDIC DEVICE FOR TESTING OF LIVE INTACT TUMOR CUBOIDS
Lockhart, E.; Horowitz, L. F.; Lim, C.; Nguyen, T.; Mehrabi, M.; Gujral, T.; Folch, A.
10.1101/2022.07.07.499178 — bioengineering — Posted on 2022-07-08
2964 Architecture and dynamics of a novel desmosome-endoplasmic reticulum organelle
Bharathan, N. K.; Giang, W.; Aaron, J. S.; Khuon, S.; Chew, T.-L.; Preibisch, S.; Trautman, E. T.; Heinrich, L.; Bogovic, J.; Bennett, D.; Ackerman, D.; Park, W.; Petruncio, A.; Weigel, A. V.; Saalfeld, S.; COSEM Project Team, ; Vogl, A. W.; Stahley, S. N.; Kowalczyk, A. P.
10.1101/2022.07.07.499185 — cell biology — Posted on 2022-07-08
2966 vsRNAfinder: a novel method for identifying high-confidence viral small RNAs from small RNA-Seq data
Cai, Z.; Fu, P.; Qiu, Y.; Wu, A.; Zhang, G.; Wang, Y.; Jiang, T.; Ge, X.; Zhu, H.; Peng, Y.
10.1101/2022.05.30.493989 — bioinformatics — Posted on 2022-07-07
2974 A multiscale spatiotemporal model including a switch from aerobic to anaerobic metabolism reproduces succession in the early infant gut microbiota
Versluis, D. M.; Schoemaker, R.; Looijesteijn, E.; Muysken, D.; Jeurink, P. V.; Paques, M.; Geurts, J. M. W.; Merks, R. M. H.
10.1101/2021.08.22.457032 — systems biology — Posted on 2022-07-07
2977 Nutrient limitation mimics artemisinin tolerance in malaria
Brown, A.; Warthan, M. D.; Aryal, A.; Liu, S.; Guler, J. L.
10.1101/2022.06.14.496121 — microbiology — Posted on 2022-07-07
2978 A multi-pronged human microglia response to Alzheimer's disease Aβ pathology
Mancuso, R.; Fattorelli, N.; Martinez-Muriana, A.; Davis, E.; Wolfs, L.; Van den Daele, J.; Geric, I.; Preman, P.; Serneels, L.; Poovathingal, S.; Balusu, S.; Verfaillie, C.; Fiers, M.; De Strooper, B.
10.1101/2022.07.07.499139 — neuroscience — Posted on 2022-07-07
2983 Saturated Fat Impairs Circadian Transcriptomics through Histone Modification of Enhancers
Pillon, N. J.; Sardon Puig, L.; Altintas, A.; Kamble, P. G.; Casani-Galdon, S.; Gabriel, B. M.; Barres, R.; Conesa, A.; Chibalin, A. V.; Naslund, E.; Krook, A.; Zierath, J. R.
10.1101/2021.02.23.432336 — physiology — Posted on 2022-07-07
2984 Immature human engineered heart tissues engraft in a guinea pig chronic injury model
von Bibra, C.; Shibamiya, A.; Baehr, A.; Geertz, B.; Koehne, M.; Stuedemann, T.; Starbatty, J.; Hornaschewitz, N.; Wolf, E.; Klymiuk, N.; Krane, M.; Kupatt, C.; Hiebl, B.; Eschenhagen, T.; Weinberger, F.
10.1101/2022.07.07.499077 — pharmacology and toxicology — Posted on 2022-07-07
2985 Nementin is a Nematode-Selective Small Molecule Agonist of Neurotransmitter Release
Harrington, S.; Knox, J. J.; Burns, A. R.; Choo, K.-L.; Au, A.; Kitner, M.; Haeberli, C.; Pyche, J.; D'Amata, C.; Kim, Y.-H.; Volpatti, J.; Guiliani, M.; Snider, J.; Wong, V.; Palmeira, B. M.; Redman, E. M.; Vaidya, A. S.; Gilleard, J. S.; Stagljar, I.; Cutler, S. R.; Kulke, D.; Dowling, J. J.; Yip, C. M.; Keiser, J.; Zasada, I.; Lautens, M.; Roy, P.
10.1101/2022.03.12.484074 — pharmacology and toxicology — Posted on 2022-07-07
2994 Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis
Wong, A. I.; Beites, T.; Planck, K. A.; Li, S.; Poulton, N. C.; Rhee, K.; Schnappinger, D.; Ehrt, S.; Rock, J. M.
10.1101/2022.07.07.499113 — microbiology — Posted on 2022-07-07
2995 Antibody-mediated prevention of vaginal HIV transmission is dictated by IgG subclass in humanized mice
Brady, J. M.; Phelps, M.; MacDonald, S. W.; Lam, E. C.; Nitido, A.; Parsons, D.; Boutros, C. L.; Deal, C. E.; Tanno, S.; Natarajan, H.; Ackerman, M. E.; Vrbanac, V. D.; Balazs, A. B.
10.1101/2022.07.07.499107 — immunology — Posted on 2022-07-07
2997 Neural Correlates of Statistical Learning in Developmental Dyslexia: An Electroencephalography Study
Daikoku, T.; Jentschke, S.; Tsogli, V.; Bergstrom, K.; Lachmann, T.; Ahissar, M.; Koelsch, S.
10.1101/2022.07.06.498909 — neuroscience — Posted on 2022-07-07
2999 Electrical stimulation of temporal and limbic circuitry produces distinct responses in human ventral temporal cortex
Huang, H.; Gregg, N. M.; Valencia, G. O.; Brinkmann, B. H.; Lundstrom, B. N.; Worrell, G. A.; Miller, K. J.; Hermes, D.
10.1101/2022.07.06.498994 — neuroscience — Posted on 2022-07-07
3000 Timing along the cardiac cycle modulates neural signals of reward-based learning
Fouragnan, E. F.; Hosking, B.; Cheung, Y.; Prakash, B. A.; Rushworth, M. F.; Sel, A.
10.1101/2022.07.07.498947 — neuroscience — Posted on 2022-07-07
3003 Neurons protect themselves by active shrinkage upon axonal transection
Aydin, M. S.; Bay, S.; Yigit, E. N.; Ozgul, C.; Oguz, E. K.; Konuk, E. Y.; Aysit, N.; Cengiz, N.; Erdogan, E.; Him, A.; Kocak, M.; Eroglu, E.; Ozturk, G.
10.1101/2022.07.06.499034 — neuroscience — Posted on 2022-07-07
3005 XDec Simplex Map of Breast Cancer Cell States Enables Precise Modeling and Targeting of Breast Cancer
Murillo, O. D.; Petrosyan, V.; LaPlante, E. L.; Dobrolecki, L. E.; Lewis, M. T.; Milosavljevic, A.
10.1101/2022.07.06.498858 — cancer biology — Posted on 2022-07-07
3007 Chaperone-mediated Autophagy Deficiency Reprograms Cancer Metabolism Via TGFβ Signaling to drive Mesenchymal Tumor Growth
Zhou, X.; shi, y.; Shirokova, V.; Kochetkova, E.; becirovic, t.; zhang, b.; kaminsky, v.; Linskog, C.; hydbring, p.; ekman, s.; genanader, m.; norberg, e.; Norberg, H.
10.1101/2022.07.07.499098 — cancer biology — Posted on 2022-07-07
3010 3D single cell migration driven by temporal correlation between oscillating force dipoles
Godeau, A. L.; Leoni, M.; Comelles, J.; Guyomart, T.; Lieb, M.; Delanoe-Ayari, H.; Ott, A.; Harlepp, S.; Sens, P.; Riveline, D.
10.1101/2020.05.07.081984 — biophysics — Posted on 2022-07-07
3015 Model-based hearing-enhancement strategies for cochlear synaptopathy pathologies
Drakopoulos, F.; Vasilkov, V.; Osses Vecchi, A.; Wartenberg, T.; Verhulst, S.
10.1101/2022.01.10.475652 — bioengineering — Posted on 2022-07-07
3016 Biological evaluation of novel side chain containing CQTrICh-analogs as antimalarials and their development as PfCDPK1 kinase inhibitors
Irfan, I.; Uddin, A.; Jain, R.; Gupta, A.; Gupta, S.; Napoleon, J. V.; Hussain, A.; Alajmi, M. F.; Joshi, M. C.; Hasan, P.; Abid, M.; Singh, S.
10.1101/2022.07.07.498981 — biochemistry — Posted on 2022-07-07
3017 A Buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72h in mouse femoral fracture models
Wolter, A.; Bucher, C. H.; Kurmies, S.; Schreiner, V.; Konietschke, F.; Hohlbaum, K.; Klopfleisch, R.; Loehning, M.; Thoene-Reineke, C.; Buttgereit, F.; Huwyler, J.; Jirkof, P.; Rapp, A. E.; Lang, A.
10.1101/2022.07.05.498859 — animal behavior and cognition — Posted on 2022-07-07
3020 Increased mutation rate and interlocus gene conversion within human segmental duplications.
Vollger, M. R.; DeWitt, W. S.; Dishuck, P. C.; Harvey, W. T.; Guitart, X.; Goldberg, M. E.; Rozanski, A.; Lucas, J.; Asri, M.; The Human Pangenome Reference Consortium, ; Munson, K. M.; Lewis, A. P.; Hoekzema, K.; Logsdon, G. A.; Porubsky, D.; Paten, B.; Harris, K.; Hsieh, P.; Eichler, E. E.
10.1101/2022.07.06.498021 — genomics — Posted on 2022-07-07
3021 Integrating genetic and oral histories of Southwest Indian populations
Biddanda, A.; Bandyopadhyay, E.; de la Fuente Castro, C.; Witonsky, D.; Pasupuleti, N.; Fonseca, R.; Freilich, S.; Moots, H. M.; Stanisavic, J.; Willis, T.; Menon, A.; Mustak, M. S.; Kodira, C. D.; Naren, A. P.; Sikdar, M.; Rai, N.; Raghavan, M.
10.1101/2022.07.06.498959 — genetics — Posted on 2022-07-07
3024 Spatio-temporal development of the urban heat island in a socioeconomically diverse tropical city
Ramsay, E. E.; Duffy, G. A.; Burge, K.; Taruc, R. R.; Fleming, G. M.; Faber, P. A.; Chown, S. L.
10.1101/2022.07.07.499124 — ecology — Posted on 2022-07-07
3028 Origin and segregation of the human germline
Castillo-Venzor, A.; Penfold, C. A.; Morgan, M. D.; Tang, W. W. C.; Kobayashi, T.; Wong, F. C. K.; Bergmann, S.; Slatery, E.; Boroviak, T. E.; Marioni, J.; Surani, M. A.
10.1101/2022.07.06.498671 — developmental biology — Posted on 2022-07-07
3029 Identification of a multipotent lung progenitor for lung regeneration
Rosen, C.; Shetzen, E.; Milman -Krentsis, I.; Orgad, R.; Su, X.; Yadav, R.; Shemesh, M.; Biram, A.; Shulman, Z.; Eventov-Friedman, S.; Maharjan, M.; Qi, Y.; Wang, J.; Reisner, Y.
10.1101/2022.07.07.498730 — cell biology — Posted on 2022-07-07
3031 Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis
Stearns-Reider, K. M.; Hicks, M. R.; Hammond, K. G.; Reynolds, J. C.; Maity, A.; Kurmangaliyev, Y. Z.; Chin, J. W.; Stieg, A. Z.; Geisse, N. A.; Hohlbauch, S.; Kaemmer, S.; Schmitt, L. R.; Pham, T. T.; Yamauchi, K.; Novitch, B. G.; Wollman, R. R.; Hansen, K. C.; Pyle, A. D.; Crosbie, R. H.
10.1101/2022.07.07.497559 — cell biology — Posted on 2022-07-07
3034 Detecting aquatic pathogens with field-compatible dried qPCR assays
Rieder, J.; Martin-Sanchez, P. M.; Ahmed, O.; Adrian-Kalchhauser, I.; Eiler, A.
10.1101/2022.07.07.499119 — microbiology — Posted on 2022-07-07
3036 Starvation Response and RNA Polymerase Guide Antibiotic-induced Mutable Gambler Cells
Zhai, Y.; Minnick, P. J.; Pribis, J. P.; Garcia-Villada, L.; Hastings, P. J.; Herman, C.; Rosenberg, S. M.
10.1101/2022.07.06.499071 — microbiology — Posted on 2022-07-07
3038 From cereus to anthrax and back again: The role of the PlcR regulator in the cross-over strain Bacillus cereus G9241
Manoharan, S.; Taylor-Joyce, G.; Brooker, T.; Hernandez-Rodriguez, C. S.; Hapeshi, A.; Baldwin, V.; Baillie, L.; Oyston, P.; Waterfield, N. R.
10.1101/2022.07.06.498675 — microbiology — Posted on 2022-07-07
3043 Meditators probably show increased behaviour-monitoring related neural activity
Bailey, N.; Geddes, H.; Zannettino, I.; Humble, G.; Payne, J.; Baell, O.; Emonson, M.; Chung, S. W.; Hill, A. T.; Rogasch, N. C.; Hohwy, J.; Fitzgerald, P.
10.1101/2022.07.07.499152 — neuroscience — Posted on 2022-07-07
3044 An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish
McCarthy, M. M.; Hardy, M. J.; Leising, S. E.; LaFollette, A. M.; Stewart, E. S.; Cogan, A. S.; Sanghal, T.; Matteo, K.; Oxford, J. T.; Rohn, T. T.
10.1101/2022.07.07.499128 — neuroscience — Posted on 2022-07-07
3046 Prox2+ and Runx3+ neurons regulate esophageal motility
Lowenstein, E. D.; Ruffault, P.-L.; Misios, A.; Osman, K. L.; Li, H.; Thompson, R.; Song, K.; Dietrich, S.; Li, X.; Vladimirov, N.; Brunet, J.-F.; Woehler, A.; Zampieri, N.; Kuhn, R.; Jia, S.; Lewin, G. R.; Rajewsky, N.; Lever, T. E.; Birchmeier, C.
10.1101/2022.07.07.499111 — neuroscience — Posted on 2022-07-07
3047 Deep proteomic analysis of human microglia and model systems reveal fundamental biological differences of in vitro and ex vivo cells
Lloyd, A. F.; Martinez-Muriana, A.; Hou, P.; Davis, E.; Mancuso, R.; Brenes-Murillo, A. J.; Geric, I.; Snellinx, A.; Craessaerts, K.; Theys, T.; Fiers, M.; De Strooper, B.; Howden, A. J.
10.1101/2022.07.07.498804 — neuroscience — Posted on 2022-07-07
3049 Dopamine builds and reveals reward-associated latent behavioral attractors
Naude, J.; Sarazin, M. X.; Mondoloni, S.; Hanesse, B.; Vicq, E.; Amegandjin, F.; Mourot, A.; Faure, P.; Delord, B.
10.1101/2022.07.07.499108 — neuroscience — Posted on 2022-07-07
3053 An integrated 'omics approach highlights the role of epigenetic events to explain and predict response to neoadjuvant chemotherapy and bevacizumab
Fleischer, T.; Haugen, M. H.; Ankill, J.; Silwal-Pandit, L.; Borresen-Dale, A.-L.; Hedenfalk, I.; Hatschek, T.; Tost, J.; Engebraaten, O.; Kristensen, V. N.
10.1101/2022.07.06.498803 — cancer biology — Posted on 2022-07-07
3055 A deep learning approach for improved detection of homologous recombination deficiency from shallow genomic profiles
Andre, G.; Coletta, T.; Pozzorini, C.; Marques, A. C.; Bieler, J.; Kempfer, R.; Chong, C.; Saitta, A.; Smith, E.; Macheret, M.; Janiszewski, A.; Bonilla, X.; Bonet, J.; Santos-Silva, H.; Postl, M.; Wozelka-Oltjan, L.; Arrigo, N.; Willig, A.; Grimm, C.; Mullauer, L.; Xu, Z.
10.1101/2022.07.06.498851 — cancer biology — Posted on 2022-07-07
3057 Loss of mechanical homeostasis drives epithelial acinar eversion
Narayanan, V.; Purkayastha, P.; Yu, B.; Cabe, J. I.; Dickinson, R. B.; Conway, D. E.; Lele, T.
10.1101/2022.07.06.499064 — biophysics — Posted on 2022-07-07
3059 Evaluation of epigenetic age acceleration scores and their associations with CVD related phenotypes in a population cohort
Chervova, O.; Chernysheva, E.; Panteleeva, K.; Widayati, T.; Maximov, V.; Ryabikov, A.; Tillmann, T.; Pikhart, H.; Bobak, M.; Voloshin, V.; Malyutina, S.; Beck, S.
10.1101/2022.07.06.498980 — bioinformatics — Posted on 2022-07-07
3060 MC profiling: a novel approach to analyze DNA methylation heterogeneity in genome-wide bisulfite sequencing data
De Riso, G.; Sarnataro, A.; Scala, G.; Cuomo, M.; Della Monica, R.; Amente, S.; Chiariotti, L.; Miele, G.; Cocozza, S.
10.1101/2022.07.06.498979 — bioinformatics — Posted on 2022-07-07
3063 Single-cell reference mapping to construct and extend cell type hierarchies
Michielsen, L.; Lotfollahi, M.; Strobl, D.; Sikkema, L.; Reinders, M.; Theis, F. J.; Mahfouz, A.
10.1101/2022.07.07.499109 — bioinformatics — Posted on 2022-07-07
3065 DeepBend: An Interpretable Model of DNA Bendability
Rahman Khan, S.; Sakib, S.; Rahman, M. S.; Samee, M. A. H.
10.1101/2022.07.06.499067 — bioinformatics — Posted on 2022-07-07
3067 Bioorthogonal in-cell Labeling and Profiling of N6-isopentenyladenosine (i6A) Modified RNA
Wang, S.; Li, Y.; Zhou, H.; Wang, L.; Gan, Y.; Zhang, S.; Zheng, Y. Y.; Sheng, j.; Wang, R.
10.1101/2022.07.07.496599 — biochemistry — Posted on 2022-07-07
3072 Genetic diversity in global populations of the Critically Endangered addax (Addax nasomaculatus) and its implications for conservation
Dicks, K. L.; Ball, A.; Banfield, L.; Barrios, V.; Boufaroua, M.; Chetoui, A.; Chuven, J.; Craig, M.; Faqeer, M. Y. A.; Garba, H. H. M.; Guedara, H.; Harouna, A.; Ivy, J.; Najjar, C.; Petretto, M.; Pusey, R.; Rabeil, T.; Riordan, P.; Senn, H. V.; Taghouti, E.; Wacher, T.; Woodfine, T.; Gilbert, T.
10.1101/2022.07.07.499131 — genetics — Posted on 2022-07-07
3076 Epidermal threads reveal the origin of hagfish slime
Zeng, Y.; Plachetzki, D. C.; Nieders, K.; Campbell, H.; Cartee, M.; Guillen, K.; Fudge, D.
10.1101/2022.07.06.499062 — evolutionary biology — Posted on 2022-07-07
3079 mRNA decapping machinery targets LBD3/ASL9 transcripts to allow developmental changes in Arabidopsis
Zuo, Z.; Roux, M. E.; Chevalier, J.; Dagdas, Y.; Yamashino, T.; Hojgaard, S. D.; Knight, E.; Ostergaard, L.; Rodriguez, E.; petersen, m.
10.1101/2022.07.06.499076 — developmental biology — Posted on 2022-07-07
3081 Nucleoside-modified mRNA-based influenza vaccines circumvent problems associated with H3N2 vaccine strain egg-adaptation
Gouma, S.; Parkhouse, K.; Weirick, M.; Muramatsu, H.; Pardi, N.; Fan, S. H. Y.; Weissman, D.; Hensley, S. E.
10.1101/2022.07.06.499081 — microbiology — Posted on 2022-07-07
3083 Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity
Karagiannis, T. T.; Dowrey, T. W.; Villacorta-Martin, C.; Montano, M.; Reed, E.; Andersen, S. L.; Perls, T. T.; Monti, S.; Murphy, G. J.; Sebastiani, P.
10.1101/2022.07.06.498968 — immunology — Posted on 2022-07-07
3086 Using colony size to measure fitness in Saccharomyces cerevisiae
Miller, J. H.; Fasanello, V. J.; Liu, P.; Longan, E. R.; Botero, C. A.; Fay, J. C.
10.1101/2022.07.07.499129 — evolutionary biology — Posted on 2022-07-07
3090 Three-dimensional visualization of moss rhizoid system by refraction-contrast X-ray micro-computed tomography
Yamaura, R.; Tamaoki, D.; Kamachi, H.; Yamauchi, D.; Mineyuki, Y.; Uesugi, K.; Hoshino, M.; Suzuki, T.; Shimazu, T.; Kasahara, H.; Kamada, M.; Hanba, Y.; Kume, A.; Fujita, T.; Karahara, I.
10.1101/2022.07.07.499130 — plant biology — Posted on 2022-07-07
3091 Nascent transcription and the associated cis-regulatory landscape in rice
Choi, J. Y.; Platts, A. E.; Johary, A.; Purugganan, M.; Joly-Lopez, Z.
10.1101/2022.07.06.498888 — plant biology — Posted on 2022-07-07
3093 Transcriptional Profiles Analysis of COVID-19 and Malaria Patients Reveals Potential Biomarkers in Children
Lambert, N.; Jonas, K.-O. A.; Rissy, W. M.; Diane, U.; Murithi, K.; Peter, K.; Awe, O. I.; Dillman, A.
10.1101/2022.06.30.498338 — bioinformatics — Posted on 2022-07-07
3095 Tracking the emergence and dissemination of a blaNDM-23 Gene in a Multi-Drug Resistance Plasmid of Klebsiella pneumoniae
Garcia-Gonzalez, N.; Beamud, B.; Fuster-Escriva, B.; Giner, S.; Domniguez Marquez, M. V.; Sanchez, A.; Sevilla, J.; Coque, T.; Gimeno, C.; Gonzalez-Candelas, F.
10.1101/2022.07.05.498915 — microbiology — Posted on 2022-07-07
3096 Reproducibility of neuroimaging studies of brain disorders with hundreds -not thousands- of participants
Libedinsky, I.; Helwegen, K.; Dannlowski, U.; Fornito, A.; Repple, J.; Zalesky, A.; Alzheimer's Disease Neuroimaging Initiative, ; Alzheimer's Disease Repository Without Borders Investigators, ; Breakspear, M.; van den Heuvel, M.
10.1101/2022.07.05.498443 — neuroscience — Posted on 2022-07-07
3098 In vitro and in vivo immunogenicity assessment of protein aggregate characteristics
Thorlaksen, C.; Schultz, H. S.; Gammelgaard, S. K.; Jiskoot, W.; Hatzakis, N. S.; Nielsen, F. S.; Solberg, H.; Fodera, V.; Bartholdy, C.; Groenning, M.
10.1101/2022.07.06.498969 — immunology — Posted on 2022-07-07
3101 Integration of heterogeneous biological data in multiscale mechanistic model calibration: application to lung adenocarcinoma
Palgen, J.-L.; Perrillat-Mercerot, A.; Ceres, N.; Peyronnet, E.; Coudron, M.; Tixier, E.; Illigens, B. M. W.; Bosley, J.; L'Hostis, A.; Monteiro, C.
10.1101/2022.01.17.476676 — systems biology — Posted on 2022-07-07
3102 Genomic heterogeneity in pancreatic cancer organoids and its stability with culture
Usman, O.; Zhang, L.; Xie, G.; Kocher, H. M.; Hwang, C.-i.; Wang, Y. J.; Mallory, X. F.; Irianto, J.
10.1101/2022.07.03.498602 — cancer biology — Posted on 2022-07-07
3104 Force-dependent recruitment of Piezo1 drives focal adhesion maturation and calcium entry in normal but not tumor cells
Yao, M.; Tijore, A. S.; Cheng, D.; Li, J. V.; Hariharan, A.; Martinac, B.; Tran Van Nhieu, G.; Cox, C. D.; Sheetz, M.
10.1101/2020.03.09.972307 — cell biology — Posted on 2022-07-07
3105 Fibromyalgia patients with high levels of anti-satellite glia cell IgG antibodies present with more severe symptoms
Krock, E.; Morado-Urbina, C. E.; Menezes, J.; Hunt, M. A.; Sandstrom, A.; Kadetoff, D.; Tour, J.; Verma, V.; Kultima, K.; Haglund, L.; Meloto, C. B.; Diatchenko, L.; Kosek, E.; Svensson, C.
10.1101/2022.07.06.498940 — neuroscience — Posted on 2022-07-06
3107 A cross-scale analysis to understand and quantify effects of photosynthetic enhancement on crop growth and yield
Wu, A.; Brider, J.; Busch, F. A.; Chen, M.; Chenu, K.; Clarke, V. C.; Collins, B.; Ermakova, M.; Evans, J. R.; Farquhar, G. D.; Forster, B.; Furbank, R. T.; Groszmann, M.; Hernandez, M. A.; Long, B. M.; Mclean, G.; Potgieter, A.; Price, G. D.; Sharwood, R. E.; Stower, M.; van Oosterom, E.; von Caemmerer, S. M.; Whitney, S.; Hammer, G.
10.1101/2022.07.06.498957 — plant biology — Posted on 2022-07-06
3109 Neural coding of temperature with a DNA-based spiking chemical neuron
Lobato-Dauzier, N.; Baccouche, A.; Gines, G.; Levi, T.; Rondelez, Y.; Fujii, T.; Kim, S. H.; Aubert-Kato, N.; Genot, A. J.
10.1101/2022.07.06.498929 — biochemistry — Posted on 2022-07-06
3110 Diet as a major driver of endosymbiont proliferation in cereal weevils
Dell'Aglio, E.; Lacotte, V.; Peignier, S.; Rahioui, I.; Benzaoui, F.; Vallier, A.; Silva, P. d.; Desouhant, E.; Heddi, A.; Rebollo, R.
10.1101/2022.07.06.498660 — evolutionary biology — Posted on 2022-07-06
3112 NAD+ repletion with niacin counteracts cancer cachexia
Beltra, M.; Pöllänen, N.; Fornelli, C.; Tonttila, K.; Hsu, M. Y.; Zampieri, S.; Moletta, L.; Porporato, P. E.; Kivelä, R.; Sandri, M.; Hulmi, J. J.; Sartori, R.; Pirinen, E.; Penna, F.
10.1101/2022.07.06.499010 — molecular biology — Posted on 2022-07-06
3115 Obesity Disrupts Pituitary UPR Leading to NAFLD
Qian, Q.; Li, M.; Zhang, Z.; Davis, S.; Rahmouni, K.; Norris, A. W.; Cao, H.; Ding, W.-X.; Yang, L.
10.1101/2022.07.06.498610 — physiology — Posted on 2022-07-06
3121 Performances of bioinformatics tools for the analysis of sequencing data of Mycobacterium tuberculosis complex strains
Quagliaro, P.; Dziri, S.; Magdoud El Alaoui, F.; Saint Louis, P.; de Pontual, L.; Marin, J.; Carbonnelle, E.; Billard-Pomares, T.
10.1101/2022.07.05.498825 — bioinformatics — Posted on 2022-07-06
3123 The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9
Bayly-Jones, C.; Ho, B. H. T.; Lau, C.; Leung, E. W. W.; D'Andrea, L.; Lupton, C. J.; Ekkel, S. M.; Venugopal, H.; Whisstock, J. C.; Mollnes, T. E.; Spicer, B. A.; Dunstone, M. A.
10.1101/2022.07.06.498960 — biochemistry — Posted on 2022-07-06
3125 Gaps and complex structurally variant loci in phased genome assemblies
Porubsky, D.; Vollger, M. R.; Harvey, W. T.; Rozanski, A. N.; Ebert, P.; Hickey, G.; Hasenfeld, P.; Sanders, A. D.; Stober, C.; Human Pangenome Reference Consortium (HPRC), ; Korbel, J. O.; Paten, B.; Marschall, T.; Eichler, E. E.
10.1101/2022.07.06.498874 — genomics — Posted on 2022-07-06
3126 Epigenetic biomarkers of autoimmune risk and protective antioxidant signaling in methylmercury-exposed adults
Weinhouse, C.; Perez, L.; Ryde, I.; Goodrich, J. M.; Miranda, J. J.; Hsu-Kim, H.; Murphy, S. K.; Meyer, J. N.; Pan, W. K.
10.1101/2022.07.05.498896 — genomics — Posted on 2022-07-06
3128 A phylogenomically informed five-order system for the closest relatives of land plants
Hess, S.; Williams, S. K.; Busch, A.; Irisarri, I.; Delwiche, C. F.; de Vries, S.; Darienko, T.; Roger, A. J.; Archibald, J. M.; Buschmann, H.; von Schwartzenberg, K.; de Vries, J.
10.1101/2022.07.06.499032 — evolutionary biology — Posted on 2022-07-06
3129 Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes
Hildebrandt, R. P.; Moss, K. R.; Janusz-Kaminska, A.; Knudson, L. A.; Denes, L. T.; Saxena, T.; Boggupalli, D.; Li, Z.; Lin, K.; Bassell, G. J.; Wang, E. T.
10.1101/2022.07.06.498900 — cell biology — Posted on 2022-07-06
3131 Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
Yeh, Y.-T.; Sona, C.; Yan, X.; Pathak, A.; McDermott, M. I.; Xie, Z.; Liu, L.; Arunagiri, A.; Wang, Y.; Cazenave-Gassiot, A.; Ghosh, A.; von Meyenn, F.; Kumarasamy, S.; Najjar, S. M.; Jia, S.; Wenk, M. R.; Traynor-Kaplan, A.; Arvan, P.; Barg, S.; Bankaitis, V.; Poy, M. N.
10.1101/2022.07.06.498991 — cell biology — Posted on 2022-07-06
3135 Dual targeting factors are required for LXG toxin export by the bacterial type VIIb secretion system
Klein, T. A.; Grebenc, D. W.; Shah, P. Y.; McArthur, O. D.; Dickson, B. H.; Surette, M. G.; Kim, Y.; Whitney, J.
10.1101/2022.07.06.499029 — microbiology — Posted on 2022-07-06
3136 A yeast-based tool for mammalian DGATs inhibitors screening
Gajdos, P.; Ledesma-Amaro, R.; Nicaud, J.-M.; Rossignol, t.
10.1101/2022.07.06.498986 — microbiology — Posted on 2022-07-06
3137 Autolysis affects the iron cargo of ferritins in neurons and glial cells at different rates in the human brain
Sunkara, S.; Radulovic, S.; Lipovsek, S.; Birkl, C.; Eggenreich, S.; Birkl-Toeglhofer, A. M.; Schinagl, M.; Funk, D.; Stoeger-Pollach, M.; Haybaeck, J.; Goessler, W.; Ropele, S.; Leitinger, G.
10.1101/2022.01.26.477869 — neuroscience — Posted on 2022-07-06
3144 Predicting leaf traits across functional groups using reflectance spectroscopy
Kothari, S.; Beauchamp-Rioux, R.; Blanchard, F.; Crofts, A. L.; Girard, A.; Guilbeault-Mayers, X.; Hacker, P. W.; Pardo, J.; Schweiger, A. K.; Demers-Thibeault, S.; Bruneau, A.; Coops, N. C.; Kalacska, M.; Vellend, M.; Laliberte, E.
10.1101/2022.07.01.498461 — ecology — Posted on 2022-07-06
3146 ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia
Kreider-Letterman, G.; Castillo, A.; Mahlandt, E. K.; Goedhart, J.; Rabino, A. F.; Goiocoechea, S. M.; Garcia-Mata, R.
10.1101/2022.06.22.497207 — cell biology — Posted on 2022-07-06
3147 A FRET biosensor, SMART, monitors necroptosis in renal tubular epithelial cells in a cisplatin-induced kidney injury model
Murai, S.; Takakura, K.; Sumiyama, K.; Moriwaki, K.; Terai, K.; Komazawa-Sakon, S.; Yamaguchi, Y.; Mikami, T.; Araki, K.; Ohmuraya, M.; Matsuda, M.; Nakano, H.
10.1101/2022.06.18.496655 — cell biology — Posted on 2022-07-06
3151 Plant-associated fungi support bacterial resilience following water limitation
Hestrin, R.; Kan, M.; Lafler, M.; Wollard, J.; Kimbrel, J.; Ray, P.; Blazewicz, S. J.; Stuart, R.; Craven, K. D.; Firestone, M. K.; Nuccio, E. E.; Pett-Ridge, J.
10.1101/2022.03.05.483112 — ecology — Posted on 2022-07-06
3152 The energy requirements of ion homeostasis determine the lifespan of starving bacteria
Schink, S. J.; Polk, M.; Athaide, E.; Mukherjee, A.; Ammar, C.; Liu, X.; Oh, S.; Chang, Y.-F.; Basan, M.
10.1101/2021.11.22.469587 — microbiology — Posted on 2022-07-06
3154 Identification of new growth regulators using cross-species network analysis in plants
Curci, P. L.; Zhang, J.; Mähler, N.; Seyfferth, C.; Mannapperuma, C.; Diels, T.; Van Hautegem, T.; Jonsen, D.; Street, N. R.; Hvidsten, T. R.; Hertzberg, M.; Nilsson, O.; Inze, D.; Nelissen, H.; Vandepoele, K.
10.1101/2021.10.25.465753 — plant biology — Posted on 2022-07-06
3156 Fascin1 accelerates serrated pathway carcinogenesis by remodeling adherens junctions and restoring Wnt signaling.
Esmaeilniakooshkghazi, A.; Pham, E.; George, S. P.; Ahrorov, A.; Villagomez, F. R.; Byington, M.; Mukhopadhyay, S.; Patnaik, S.; Conrad, J. C.; Naik, M.; Ravi, S.; Tebbuttt, N.; Mooi, J.; Reehorst, C. M.; Mariadason, J. M.; Khurana, S.
10.1101/2022.06.14.496198 — cancer biology — Posted on 2022-07-06
3158 Biased mutagenesis and H3K4me1-targeted DNA repair in plants
Quiroz, D.; Lopez-Mateos, D.; Zhao, K.; Carbonell-Bejerano, P.; Yarov-Yarovoy, V.; Monroe, G.
10.1101/2022.05.28.493846 — genomics — Posted on 2022-07-06
3161 CLASP1 is essential for neonatal lung function and survival in mice
Pereira, A. L.; da Silva, T. F.; Ferreira, L. T.; Jaegle, M.; Buscop-van Kempen, M.; Rottier, R.; van Ijcken, W. F. J.; Brites, P.; Galjart, N.; Maiato, H.
10.1101/2022.04.27.489792 — developmental biology — Posted on 2022-07-06
3164 Coupling of NOD2 to GIV is Required for Bacterial Sensing
Katkar, G. D.; Anandachar, M. S.; Sinha, S.; Ibeawuchi, S.-R.; Espinoza, C. R.; Coates, J.; Malhotra, Y. S.; Mullick, M.; Castillo, V.; Vo, D. T.; Sahoo, D.; Ghosh, P.
10.1101/2022.04.26.489574 — immunology — Posted on 2022-07-06
3166 Coordinated regulation of CB1 cannabinoid receptors and anandamide metabolism stabilizes network activity during homeostatic scaling down
Ye, M.; Monroe, S. K.; Gay, S. M.; Armstrong, M. L.; Youngstrom, D. E.; Urbina, F. L.; Gupton, S. L.; Reisdorph, N.; Diering, G. H.
10.1101/2021.05.21.445170 — neuroscience — Posted on 2022-07-06
3167 Morphofunctional changes at the active zone during synaptic vesicle exocytosis
Radecke, J.; Seeger, R.; Kadkova, A.; Laugks, U.; Khosrozadeh, A.; Goldie, K. N.; Lucic, V.; Sorensen, J. B.; Zuber, B.
10.1101/2022.03.07.483217 — neuroscience — Posted on 2022-07-06
3168 Anterior Gradient-2 (AGR2) is overexpressed in colon cancer and is a potential biomarker of microsatellite instability (MSI) tumors
Fessart, D.; Mahouche, I.; Brouste, V.; Velasco, V.; Soubeyran, I.; Soubeyran, P.; Pernot, S.; Chevet, E.; Evrard, S.; Robert, J.; Delom, F.
10.1101/2021.09.07.459258 — cancer biology — Posted on 2022-07-06
3169 Accurate and efficient protein sequence designthrough learning concise local environment of residues
Huang, B.; Fan, T.; Wang, K.; Zhang, H.; Yu, C.; Nie, S.; Qi, Y.; Zheng, W.-M.; Han, J.; Fan, Z.; Sun, S.; Ye, S.; Yang, H.; Bu, D.
10.1101/2022.06.25.497605 — bioinformatics — Posted on 2022-07-06
3172 When less is more - Endogenous tagging with TurboID as a tool to study the native interactome of adaptor protein complexes
Stockhammer, A.; Benz, L.; Harel, S.; Natalia, V.; Wiench, L.; Freund, C.; Kuropka, B.; Bottanelli, F.
10.1101/2021.11.19.469212 — cell biology — Posted on 2022-07-06
3175 Post-vaccination Omicron infections induce broader immunity across antigenic space than prototype mRNA COVID-19 booster vaccination or primary infection
Wang, W.; Lusvarghi, S.; Subramanian, R.; Nusrat, E.; Wang, R.; Goguet, E.; Fries, A.; Echegaray, F.; Vassell, R.; Coggins, S.; Richard, S.; Lindholm, D.; Mende, K.; Ewers, E.; Larson, D.; Colombo, R.; Colombo, C.; Joseph, J.; Rozman, J.; Smith, A.; Lalani, T.; Berjohn, C.; Maves, R.; Jones, M.; Mody, R.; Huprikar, N.; Livezey, J.; Saunders, D.; Hollis-Perry, K.; Wang, G.; Ganesan, A.; Simons, M. P.; Broder, C.; Tribble, D.; Laing, E. D.; Agan, B.; Burgess, T. H.; Mitre, E.; Pollett, S.; Katzelnick, L. C.; Weiss, C. D.
10.1101/2022.07.05.498883 — microbiology — Posted on 2022-07-06
3177 Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors
Fink, E. A.; Bardine, C.; Gahbauer, S.; Singh, I.; White, K.; Gu, S.; Wan, X.; Ary, B.; Glenn, I.; O'Connell, J.; O'Donnell, H.; Fajtova, P.; Lyu, J.; Vigneron, S.; Young, N. J.; Kondratov, I. S.; O'Donoghue, A. J.; Moroz, Y.; Taunton, J.; Renslo, A. R.; Irwin, J. J.; Garcia-Sastre, A.; Shoichet, B. K.; Craik, C. S.
10.1101/2022.07.05.498881 — biophysics — Posted on 2022-07-06
3179 NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis
Lemaitre, Q. B. I.; Bartsch, N.; Kouzel, I. U.; Busengdal, H.; Richards, G. S.; Steinmetz, P. R. H.; Rentzsch, F.
10.1101/2022.07.06.498948 — developmental biology — Posted on 2022-07-06
3182 Transcriptional signatures of wheat inflorescence development
VanGessel, C.; Hamilton, J.; Tabbita, F.; Dubcovsky, J.; Pearce, S.
10.1101/2022.07.06.498941 — plant biology — Posted on 2022-07-06
3183 RNABSdb and 3plex enable deep computational investigation of triplex forming lncRNAs
Cicconetti, C.; Lauria, A.; Proserpio, V.; Tamburrini, A.; Maldotti, M.; Oliviero, S.; Molineris, I.
10.1101/2022.07.06.496678 — bioinformatics — Posted on 2022-07-06
3184 Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models
Hake, A.; Germann, A.; de Beer, C.; Thielen, A.; Däumer, M.; Preiser, W.; von Briesen, H.; Pfeifer, N.
10.1101/2022.07.06.498925 — bioinformatics — Posted on 2022-07-06
3189 Unique features of the gut microbiome characterized in animal models of Angelman Syndrome
Ulrika Beitnere, U.; Vilanova-Cuevas, B.; Christian, S.; Taylor, C.; Berg, E.; Copping, N.; V. Dindot, S.; Silverman, J.; Gareau, M. G.; Segal, D.
10.1101/2022.07.05.498914 — microbiology — Posted on 2022-07-06
3190 Phage genome cleavage enables resuscitation from Cas13-induced bacterial dormancy
Williams, M. C.; Reker, A. E.; Margolis, S. R.; Liao, J.; Wiedmann, M.; Rojas, E. R.; Meeske, A. J.
10.1101/2022.07.05.498905 — microbiology — Posted on 2022-07-06
3191 Faecal virome of the Australian grey-headed flying fox from urban/suburban environments contains novel coronaviruses, retroviruses and sapoviruses
Brussel, K. V.; Mahar, J. E.; Ortiz-Baez, A. S. E.; Carrai, M.; Spielman, D.; Boardman, W. S.; Baker, M. L.; Beatty, J. A.; Geoghegan, J. L.; Barrs, V. R.; Holmes, E. C.
10.1101/2022.07.06.498921 — microbiology — Posted on 2022-07-06
3192 Effects of Variation in Urine Sample Storage Conditions on 16S Urogenital Microbiome Analyses
Kumar, T.; Bryant, M.; Cantrell, K.; Song, S. J.; McDonald, D.; Tubb, H. M.; Farmer, S.; Lukacz, E. S.; Brubaker, L.; Knight, R.
10.1101/2022.07.05.498913 — microbiology — Posted on 2022-07-06
3193 Validated Preclinical Murine Model for Therapeutic Testing against Multidrug Resistant Pseudomonas aeruginosa
Warawa, J.; Duan, X.; Anderson, C.; Sotsky, J. B.; Cramer, D. E.; Pfeffer, T. L.; Guo, H.; Adcock, R. S.; Lepak, A. J.; Andes, D. R.; Slone, S. A.; Stromberg, A.; Gabbard, J. D.; Severson, W.; Lawrenz, M. B.
10.1101/2022.07.05.498916 — microbiology — Posted on 2022-07-06
3194 Diet prevents the expansion of segmented filamentous bacteria and ileo-colonic inflammation in a model of Crohn's disease
Metwaly, A.; Jovic, J.; Waldschmitt, N.; Khaloian, S.; Heimes, H.; Haecker, D.; Hammoudi, N.; Le Bourhis, L.; Mayorgas, A.; Siebert, K.; Basic, M.; Schwerd, T.; Allez, M.; Panes, J.; Salas, A.; Bleich, A.; Zeissig, S.; Schnupf, P.; Cominelli, F.; Haller, D.
10.1101/2022.07.06.498810 — microbiology — Posted on 2022-07-06
3197 Towards a mesoscale physical modeling framework for stereotactic-EEG recordings
Mercadal, B.; Lopez-Sola, E.; Galan-Gadea, A.; Al Harrach, M.; Sanchez, R.; Salvador, R.; Bartolomei, F.; Wendling, F.; Ruffini, G.
10.1101/2022.07.06.498826 — neuroscience — Posted on 2022-07-06
3199 Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells
Nguyen, T.; Urrutia-Cabrera, D.; Wang, L.; Lees, J.; Wang, J.-H.; Hung, S. S.; Hewitt, A. W.; Edwards, T. L.; Lim, S. Y.; Luu, C.; Guymer, R.; Wong, R. C.
10.1101/2022.07.05.498910 — neuroscience — Posted on 2022-07-06
3204 Tryptophan specialized metabolism and ER body-resident myrosinases modulate root microbiota assembly
Basak, A. K.; Piasecka, A.; Hucklenbroich, J.; Türksoy, G. M.; Guan, R.; Zhang, P.; Getzke, F.; Garrido-Oter, R.; Hacquard, S.; Strzałka, K.; Bednarek, P.; Yamada, K.; Nakano, R. T.
10.1101/2022.07.06.498822 — plant biology — Posted on 2022-07-06
3205 CEP peptide and cytokinin pathways converge on CEPD glutaredoxins to inhibit root growth
Taleski, M.; Chapman, K.; Novak, O.; Schmulling, T.; Frank, M.; Djordjevic, M. A.
10.1101/2022.07.05.498042 — plant biology — Posted on 2022-07-06
3206 Solanum lycopersicum CLASS-II KNOX genes regulate fruit anatomy via gibberellin-dependent and independent pathways.
Shtern, A.; Keren-Keiserman, A.; Mauxion, J.-P.; Furumizu, C.; Alvarez, J. P.; Amsellem, Z.; Gil, N.; Motenko, E.; Alkalai-Tuvia, S.; Fallik, E.; Gonzalez, N.; Goldshmidt, A.
10.1101/2022.07.06.498955 — plant biology — Posted on 2022-07-06
3210 Molecular architecture and dynamics of SARS-CoV-2 envelope by integrative modeling
Pezeshkian, W.; Grunewald, F.; Narykov, O.; Lu, S.; Arkhipova, V.; Solodovnikov, A.; Wassenaar, T.; Marrink, S.-J. J.; Korkin, D.
10.1101/2021.09.15.459697 — biophysics — Posted on 2022-07-06
3211 Patterns of mortality in domesticated ruminants in Ethiopia
Innocent, G.; Vance, C.; Ewing, D.; McKendrick, I. J.; Hailemariam, S.; Nwankpa, V.; Allan, F. K.; Schnier, C.; Peters, A. R.
10.1101/2022.07.04.498471 — bioinformatics — Posted on 2022-07-06
3212 Cancer subclone detection based on DNA copy number in single cell and spatial omic sequencing data
Wu, C.-Y.; Sathe, A.; Rong, J.; Hess, P. R.; Lau, B.; Grimes, S. M.; Ji, H. P.; Zhang, N. R.
10.1101/2022.07.05.498882 — bioinformatics — Posted on 2022-07-06
3216 Co-opted Genes of Algal Origin Protect C. elegans against Cyanogenic Toxins
Wang, B.; Pandey, T.; Long, Y.; Delgado-Rodriguez, S.; Daugherty, M. D.; Ma, D. K.
10.1101/2022.07.06.498920 — genetics — Posted on 2022-07-06
3218 Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology
Silva, B. M.; Veras, F. P.; Gomes, G.; Cambier, S.; Silva, G.; Quadros, A.; Caetite, D.; Nascimento, D.; Silva, C.; Silva, J.; Damasceno, S.; Schneider, A.; Beretta, F.; Batah, S.; Castro, I.; Paiva, I.; Rodrigues, T.; Salina, A. C. G.; Martins, R.; Cebinelli, G.; Bibo, N.; Jorge, D.; Nakaya, H. I.; Zamboni, D. S.; Leiria, L.; Fabro, A.; Alves-Filho, J. C.; Arruda, E.; Louzada-Junior, P.; Oliveira, R.; Cunha, L. D.; Van-Mol, P.; Vanderbeke, L.; Feys, S.; Wauters, E.; Brandolini, L.; Cunha, F.; Kohl, J.; Allegretti, M.; Lambrechts, D.; Wauters, J.; Proost, P.; Cunha, T. M.
10.1101/2022.07.03.498624 — immunology — Posted on 2022-07-06
3219 Transformation of acoustic information to sensory decision variables in the parietal cortex
Yao, J. D.; Zemlianova, K. O.; Hocker, D. L.; Savin, C.; Constantinople, C. M.; Chung, S.; Sanes, D. H.
10.1101/2022.07.05.498869 — neuroscience — Posted on 2022-07-06
3228 Tracing back primed resistance in cancer via sister cells
Dai, J.; Zheng, S.; Falco, M. M.; Bao, J.; Eriksson, J.; Perez-Villatoro, F.; Färkkilä, A.; Dufva, O.; Saeed, K.; Mustjoki, S.; Wang, Y.; Amiryousefi, A.; Tang, J.; Vähärautio, A.
10.1101/2022.07.06.498926 — cancer biology — Posted on 2022-07-06
3229 CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion, and therapeutic resistance
Lumibao, J. C.; Haak, P.; Kolossov, V. L.; Chen, J.-W. E.; Stutchman, J.; Ruiz, A.; Sivaguru, M.; Sarkaria, J. N.; Harley, B. C.; Steelman, A. J.; Gaskins, R.
10.1101/2022.07.05.498855 — cancer biology — Posted on 2022-07-06
3230 Membrane lipid reshaping underlies oxidative stress sensing by the mitochondrial proteins UCP1 and ANT1
Jovanovic, O.; Chekashkina, K.; Skulj, S.; Zuna, K.; Vazdar, M.; Bashkirov, P. V.; Pohl, E. E.
10.1101/2022.07.06.498870 — biophysics — Posted on 2022-07-06
3231 CryoEM Structures of the Human HIV-1 Restriction Factor SERINC3 and Function as a Lipid Transporter
Leonhardt, S. A.; Purdy, M. D.; Grover, J. R.; Yang, Z.; Poulos, S.; McIntire, W. E.; Tatham, E. A.; Erramilli, S.; Nosol, K.; Lai, K. K.; Ding, S.; Lu, M.; Uchil, P. D.; Finzi, A. D.; Rein, A.; Kossiakoff, A. A.; Mothes, W.; Yeager, M.
10.1101/2022.07.06.498924 — biophysics — Posted on 2022-07-06
3237 Learning alters neural activity to simultaneously support memory and action
Losey, D. M.; Hennig, J. A.; Oby, E. R.; Golub, M. D.; Sadlter, P. T.; Quick, K. M.; Ryu, S. I.; Tyler-Kabara, E. C.; Batista, A. P.; Yu, B. M.; Chase, S. M.
10.1101/2022.07.05.498856 — neuroscience — Posted on 2022-07-06
3239 FOXP2 confers oncogenic effects in prostate cancer through activating MET signalling
Zhu, X.; Chen, C.; Wei, D.; Xu, Y.; Liang, S.; Jia, W.; Li, J.; Qu, Y.; Zhai, J.; Zhang, Y.; Wu, P.; Hao, Q.; Zhang, L.; Zhang, W.; Yang, X.; Pan, L.; Qi, R.; Li, Y.; Wang, F.; Yi, R.; Yang, Z.; Wang, J.; Zhao, Y.
10.1101/2022.07.06.498943 — cancer biology — Posted on 2022-07-06
3243 LUZP1 regulates the constriction velocity of the contractile ring during cytokinesis
Hyodo, T.; Asano-Inami, E.; Ito, S.; Sugiyama, M.; Nawa, A.; Rahman, M. L.; Hasan, M. N.; Mihara, Y.; Lam, V. Q.; Karnan, S.; Ota, A.; Tsuzuki, S.; Hamaguchi, M.; Hosokawa, Y.; Konishi, H.
10.1101/2022.07.04.498656 — cell biology — Posted on 2022-07-06
3246 Temporal and Spatial Resolution of a Protein Quake that Activates Hydrogen Tunneling in Soybean Lipoxygenase
Zaragoza, J. P.; Offenbacher, A. R.; Hu, S.; Gee, C. L.; Firestein, Z. M.; Minnetian, N.; Deng, Z.; Fan, F.; Iavarone, A. T.; Klinman, J. P.
10.1101/2022.03.31.486235 — biophysics — Posted on 2022-07-05
3247 Integrative modeling reveals the molecular architecture of the Intraflagellar Transport A (IFT-A) complex
McCafferty, C. L.; Papoulas, O.; Jordan, M. A.; Hoogerbrugge, G.; Nichols, C.; Pigino, G.; Taylor, D. W.; Wallingford, J. B.; Marcotte, E. M.
10.1101/2022.07.05.498886 — biochemistry — Posted on 2022-07-05
3250 Large haploblocks underlie rapid adaptation in an invasive weed
Battlay, P.; Wilson, J.; Bieker, V. C.; Lee, C.; Prapas, D.; Petersen, B.; Craig, S.; van Boheemen, L.; Scalone, R.; de Silva, N. P.; Sharma, A.; Konstantinovic, B.; Nurkowski, K. A.; Rieseberg, L. H.; Connallon, T.; Martin, M. D.; Hodgins, K. A.
10.1101/2022.03.02.482376 — evolutionary biology — Posted on 2022-07-05
3252 Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2ε in vomeronasal sensory neurons
Lin, J. M.; Mitchell, T. A.; Rothstein, M.; Pehl, A.; Taroc, E. Z. M.; Ketreddi, R. R.; Parra, K. E.; Zuloaga, D. G.; Simoes-Costa, M.; Forni, P. E.
10.1101/2022.01.14.476379 — developmental biology — Posted on 2022-07-05
3253 Single Cell RNA-Sequence Analyses Reveal Uniquely Expressed Genes and Heterogeneous Immune Cell Involvement in the Rat Model of Intervertebral Disc Degeneration
Rohanifar, M.; Clayton, S. W.; Easson, G.; Patil, D. S.; Lee, F.; Jing, L.; Barcellona, M. N.; Speer, J. E.; Stivers, J. J.; Tang, S. Y.; Setton, L. A.
10.1101/2022.07.05.498865 — cell biology — Posted on 2022-07-05
3254 ArtinM Cytotoxicity in B cells derived from Non-Hodgkins Lymphoma is regulated by CD45 phosphatase activity and Src family kinases
Barboza, B. R.; Thomaz, S. M. d. O.; de Carvalho, A.; Espreafico, E. M.; Miyamoto, J. G.; Tashima, A. K.; Camacho, M. F.; Zelanis, A.; Roque-Barreira, M. C.; da Silva, T. A.
10.1101/2022.07.05.498876 — cell biology — Posted on 2022-07-05
3255 NHR-23 activity is necessary for developmental progression and apical extracellular matrix structure and function
Johnson, L. C.; Vo, A. A.; Clancy, J. C.; Aguilera, J. D.; Levenson, M. T.; Wohlenberg, C.; Rechtsteiner, A. D.; Ragle, J. M.; Ward, J. D.
10.1101/2021.10.27.465992 — molecular biology — Posted on 2022-07-05
3256 A small molecule ligand for the novel pain target GPR171 produces minimal reward in mice
McDermott, M. V.; Ram, A.; Mattoon, M.; Haderlie, E. E.; Raddatz, M. C.; Thomason, M. K.; Bobeck, E. N.
10.1101/2022.07.05.498847 — neuroscience — Posted on 2022-07-05
3257 The Injured Sciatic Nerve Atlas (iSNAT), Insights into the Cellular and Molecular Basis of Neural Tissue Degeneration and Regeneration
Zhao, X.-F.; Huffman, L. D.; Hafner, H.; Athaiya, M.; Finneran, M.; Kalinski, A. L.; Kohen, R.; Flynn, C.; Passino, R.; Johnson, C. N.; Kohrman, D.; Kawaguchi, R.; Yang, L.; Twiss, J. L.; Geschwind, D. H.; Corfas, G.; Giger, R. J.
10.1101/2022.06.26.497651 — neuroscience — Posted on 2022-07-05
3259 Childhood cancer mutagenesis caused by a domesticated DNA transposase
Keller, R.; Yamada, M.; Cameron, D.; Suzuki, H.; Sanghrajka, R.; Vaynshteyn, J.; Gerwin, J.; Maura, F.; Hooper, W.; Shah, M.; Robine, N.; Demarest, P.; Bayin, N. S.; Jubierre, L.; Taylor, M. D.; Joyner, A. L.; Raju, P. G.; Kentsis, A.
10.1101/2022.07.05.498128 — cancer biology — Posted on 2022-07-05
3260 Attenuated Dengue Virus PV001-DV Induces Oncolytic Cell Death and Potent Anti-Tumor Immunity
Marzo, A. L.; Goldfusky, J. W.; Daniels, P.; Willliams, M. D.; Gupta, K. H.; Lyday, B.; Chen, T.; Singh, G.; Zloza, A.
10.1101/2022.07.05.498884 — cancer biology — Posted on 2022-07-05
3261 maxATAC: genome-scale transcription-factor binding prediction from ATAC-seq with deep neural networks
Cazares, T. A.; Rizvi, F. W.; Iyer, B.; Chen, X.; Kotliar, M.; Bejjani, A.; Wayman, J. A.; Donmez, O.; Wronowski, B.; Parameswaran, S.; Kottyan, L. C.; Barski, A.; Weirauch, M. T.; Prasath, V. S.; Miraldi, E. R.
10.1101/2022.01.28.478235 — bioinformatics — Posted on 2022-07-05
3262 A Photonic Biosensor-Integrated Tissue Chip Platform for Real-Time Sensing of Lung Epithelial Inflammatory Markers
Cognetti, J. S.; Moen, M. T.; Brewer, M. G.; Bryan, M. R.; Tice, J. D.; Mcgrath, J. L.; Miller, B. L.
10.1101/2022.06.21.497028 — bioengineering — Posted on 2022-07-05
3263 Freestanding hydrogel lumens for modeling blood vessels and vasodilation
Dostie, A. M.; Lea, H. G.; Lee, U. N.; van Neel, T. L.; Berthier, E.; Theberge, A. B.
10.1101/2021.10.19.464875 — bioengineering — Posted on 2022-07-05
3267 A single amino acid in RTEL1 determines telomere length in mice
Smoom, R.; Lee May, C.; Ortiz, V.; Tigue, M.; Kolev, H.; Reizel, Y.; Morgan, A.; Egyes, N.; Lichtental, D.; Skordalakes, E.; Kaestner, K. H.; Tzfati, Y.
10.1101/2021.06.06.447246 — genetics — Posted on 2022-07-05
3273 Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice
Vanderkruk, B.; Maeshima, N.; Pasula, D. J.; An, M.; McDonald, C. L.; Lynn, F. C.; Luciani, D. S.; Hoffman, B.
10.1101/2021.01.28.428651 — cell biology — Posted on 2022-07-05
3276 Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete
Takacs, C. N.; Wachter, J.; Xiang, Y.; Karaboja, X.; Zhongqing, R.; Scott, M.; Stoner, M. R.; Irnov, I.; Jannetty, N.; Rosa, P. A.; Wang, X.; Jacobs-Wagner, C.
10.1101/2022.07.05.498848 — microbiology — Posted on 2022-07-05
3277 Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis
Levine, C.; Jadhav, R.; Yan, P.; Tsotetsi, K.; Wang, X.; Awasthi, D.; Grady, C.; Shelke, A.; Daher, S. S.; Richmann, T.; Shrestha, R.; Sukheja, P.; Patel, J.; Barnett, P. R.; Dikdan, R. J.; Kim, T.; Russo, R.; Hanna, J.; Zimmerman, M.; Dartois, V.; Freundlich, J.; Alland, D.; Kumar, P.
10.1101/2022.07.05.496887 — microbiology — Posted on 2022-07-05
3280 Bacterial Polyphosphates Induce CXCL4 and Synergize with Complement Anaphylatoxin C5a in Lung Injury
Roewe, J.; Walachowski, S.; Sharma, A.; Berthiaume, K. A.; Reinhardt, C.; Bosmann, M.
10.1101/2022.07.05.498838 — immunology — Posted on 2022-07-05
3283 Posterior integration and thalamo-frontotemporal broadcasting are impaired in disorders of consciousness
Panda, R.; Lopez-Gonzalez, A.; Gilson, M.; Gosseries, O.; Thibaut, A.; Frasso, G.; Cecconi, B.; Escrichs, A.; GIGA group collaborators, ; Deco, G.; Laureys, S.; Zamora-Lopez, G.; Annen, J.
10.1101/2021.11.08.467694 — neuroscience — Posted on 2022-07-05
3284 Loss of Tbx3 in mouse eye causes retinal angiogenesis defects reminiscent of human disease
Derbyshire, M.; Akula, S.; Wong, A.; Rawlins, K.; Voura, E. B.; Brunken, W. J.; Zuber, M. E.; Fuhrmann, S.; Moon, A. M.; Viczian, A. S.
10.1101/2022.04.20.488944 — neuroscience — Posted on 2022-07-05
3286 Beneficial Effects of Moderate Hepatic Activin A Expression on Metabolic pathways, Inflammation, and Atherosclerosis
Liu, H.; Hastings, M. H.; Kitchen, R.; Xiao, C.; Guerra, J. R. B.; Kuznetsov, A.; Rosenzweig, A.
10.1101/2022.07.05.498830 — pathology — Posted on 2022-07-05
3290 Identifying low risk insecticides to address both food shortages and the biocontrol of human schistosomiasis
Haggerty, C.; Delius, B.; Jouanard, N.; Ndao, P. D.; De Leo, G. A.; Lund, A. J.; Lopez-Carr, D.; Remais, J. V.; Riveau, G.; Sokolow, S. H.; Rohr, J. R.
10.1101/2021.01.05.425425 — ecology — Posted on 2022-07-05
3291 Regulation of Blos1 by IRE1 prevents the accumulation of Huntingtin protein aggregates
Bae, D.; Jones, R. E.; Piscopo, K. M.; Tyagi, M.; Shepherd, J. D.; Hollien, J.
10.1101/2021.09.28.462237 — cell biology — Posted on 2022-07-05
3292 A Comparison Of Fecal Glucocorticoid Metabolite Concentration And Gut Microbiota Diversity In Bonobos (Pan paniscus)
Hickmott, A. J.; Boose, K. J.; Wakefield, M. L.; Brand, C. M.; Snodgrass, J. J.; Ting, N.; White, F. J.
10.1101/2022.01.04.474930 — microbiology — Posted on 2022-07-05
3293 Bimodal inference in humans and mice
Weilnhammer, V. A.; Stuke, H.; Standvoss, K.; Sterzer, P.
10.1101/2021.08.20.457079 — neuroscience — Posted on 2022-07-05
3294 Directed growth and fusion of membrane-wall microdomains requires CASP-mediated inhibition and displacement of secretory foci
Barbosa, I. R.; De Bellis, D.; Fluckiger, I.; Bellani, E.; Grange-Guermente, M.; Hematy, K.; Geldner, N.
10.1101/2022.07.03.498613 — plant biology — Posted on 2022-07-05
3295 Saturated Fat Impairs Circadian Transcriptomics through Histone Modification of Enhancers
Pillon, N. J.; Sardon Puig, L.; Altintas, A.; Kamble, P.; Casani, S.; Gabriel, B. M.; Barres, R.; Conesa, A.; Chibalin, A. V.; Naslund, E.; Krook, A.; Zierath, J. R.
10.1101/2021.02.23.432336 — physiology — Posted on 2022-07-05
3303 AKT1-FOXO4 AXIS RECIPROACLLY REGULATES HEMOCHORIAL PLACENTATION
Kozai, K.; Moreno Irusta, A.; Iqbal, K.; Winchester, M.-L.; Scott, R. L.; Simon, M. E.; Muto, M.; Parrish, M. R.; Soares, M. J.
10.1101/2022.06.15.496110 — developmental biology — Posted on 2022-07-05
3304 Profound phenotypic and epigenetic heterogeneity of the HIV-1 infected CD4+ T cell reservoir
Wu, V. H.; Nguyen, S.; Nordin, J. M. L.; Joy, J.; Mampe, F.; Tebas, P.; Montaner, L. J.; Bar, K. J.; Vella, L. A.; Betts, M. R.
10.1101/2022.04.02.486753 — microbiology — Posted on 2022-07-05
3306 Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in vivo in CNS
Conroy, F.; Miller, R.; Alterman, J. F.; Hassler, M. R.; Echeverria, D.; Godinho, B. M. D. C.; Knox, E. G.; Sapp, E.; Sousa, J.; Yamada, K.; Mahmood, F.; Boudi, A.; Kegel-Gleason, K.; DiFiglia, M.; Aronin, N.; Khvorova, A.; Pfister, E. L.
10.1101/2022.06.29.498088 — neuroscience — Posted on 2022-07-05
3311 Benchmarks in antimicrobial peptide prediction are biased due to the selection of negative data
Sidorczuk, K.; Gagat, P.; Pietluch, F.; Kała, J.; Rafacz, D.; Bakała, L.; Słowik, J.; Kolenda, R.; Roediger, S.; Fingerhut, L. C.; Cooke, I.; Mackiewicz, P.; Burdukiewicz, M.
10.1101/2022.05.30.493946 — bioinformatics — Posted on 2022-07-05
3312 Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico
Castelan-Sanchez, H. G.; Delaye, L.; Inward, R. P.; Dellicour, S.; Gutierrez, B.; Martinez de la Vina, N.; Pybus, O.; de Anda Jauregui, G.; Guzman, P.; Flores Garrido, M.; Fontanelli, O.; Rosales, M. H.; Meneses, A.; Olmedo-Alvarez, G.; Herrera-Estrella, A.; Boukadida, C.; Sanchez-Flores, A.; Munoz-Medina, J. E.; Comas-Garcia, A.; Gomez-Gil, B.; Zarate, S.; Taboada, B.; Lopez, S.; Arias, C. F.; Kraemer, M. U. G.; Lazcano, A.; Escalera-Zamudio, M.
10.1101/2022.07.05.498834 — evolutionary biology — Posted on 2022-07-05
3314 Adaptive protein evolution through length variation in short tandem repeats
Reinar, W. B.; Greulich, A.; Sto, I. M.; Knutsen, J. B.; Reitan, T.; Torresen, O. K.; Jentoft, S.; Butenko, M. A.; Jakobsen, K. S.
10.1101/310045 — evolutionary biology — Posted on 2022-07-05
3315 COVID-19 Neuropathology: evidence for SARS-CoV-2 invasion of Human Brainstem Nuclei
Emmi, A.; Rizzo, S.; Barzon, L.; Sandre, M.; Carturan, E.; Sinigaglia, A.; Riccetti, S.; della Barbera, M.; Boscolo-Berto, R.; Cocco, P.; Macchi, V.; Antonini, A.; De Gaspari, M.; Basso, C.; De Caro, R.; Porzionato, A.
10.1101/2022.06.29.498117 — neuroscience — Posted on 2022-07-05
3316 Transcriptomic similarities and differences between mouse models and human Alzheimer's Disease
De Bastiani, M. A.; Bellaver, B.; Carello-Collar, G.; Zimmermann, M.; Kunach, P.; Lima-Filho, R. A. S.; Forner, S.; Martini, A. C.; Pascoal, T. A.; Lourenco, M. V.; Rosa-Neto, P.; Zimmer, E. R.
10.1101/2021.06.09.447404 — neuroscience — Posted on 2022-07-05
3318 The curse of optimism: a persistent distraction by novelty
Modirshanechi, A.; Xu, H. A.; Lin, W.-H.; Herzog, M. H.; Gerstner, W.
10.1101/2022.07.05.498835 — neuroscience — Posted on 2022-07-05
3321 Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents
Maekawa, T.; Sakitani, N.; Ryu, Y.; Takashima, A.; Murase, S.; Fink, J.; Nagao, M.; Ogata, T.; Shinohara, M.; Sawada, Y.
10.1101/2022.07.05.498781 — bioengineering — Posted on 2022-07-05
3322 The long noncoding RNA Charme supervises cardiomyocytes maturation by controlling cell differentiation programs in the developing heart
Taliani, V.; Buonaiuto, G.; Desideri, F.; Setti, A.; Santini, T.; Galfre, S.; Nicoletti, C.; Schirone, L.; Mariani, D.; Valente, V.; Sciarretta, S.; Perlas, E.; Musaro, A.; Bozzoni, I.; Ballarino, M.
10.1101/2022.07.05.498800 — molecular biology — Posted on 2022-07-05
3323 Sleep alterations in a mouse model of Spinocerebellar ataxia type 3
Tsimpanouli, M.-E.; Ghimire, A.; Barget, A. J.; Weston, R.; Paulson, H. L.; Costa, M. d. C.; Watson, B. O.
10.1101/2022.07.05.498300 — neuroscience — Posted on 2022-07-05
3324 Noninvasive cancer detection by extracting and integrating multi-modal data from whole-methylome sequencing of plasma cell-free DNA
Bie, F.; Wang, Z.; Li, Y.; Hong, Y.; Han, T.; Lv, F.; Yang, S.; Li, S.; Li, X.; Nie, P.; Zang, R.; Zhang, M.; Song, P.; Feng, F.; Guo, W.; Duan, J.; Bai, G.; Li, Y.; Huai, Q.; Zhou, B.; Huang, Y.; Chen, W.; Tan, F.; Gao, S.
10.1101/2022.07.04.498641 — cancer biology — Posted on 2022-07-05
3327 Integrating analog and digital modes of gene expression at Arabidopsis FLC
Antoniou-Kourounioti, R. L.; Meschichi, A.; Reeck, S.; Berry, S.; Menon, G.; Zhao, Y.; Fozard, J.; Holmes, T.; Wang, H.; Hartley, M.; Dean, C.; Rosa, S.; Howard, M.
10.1101/2022.07.04.498694 — molecular biology — Posted on 2022-07-05
3331 Synthesis reveals biotic homogenisation and differentiation are both common
Blowes, S.; McGill, B.; Brambilla, V.; Chow, C. F. Y.; Engel, T.; Fontrodona-Eslava, A.; Martins, I. S.; McGlinn, D.; Moyes, F.; Sagouis, A.; Shimadzu, H.; van Klink, R.; Xu, W.-B.; Gotelli, N. J.; Magurran, A.; Dornelas, M.; Chase, J.
10.1101/2022.07.05.498812 — ecology — Posted on 2022-07-05
3333 Mapping the Spatial Dynamics of the Human Oral Mucosa in Chronic Inflammatory Disease
Caetano, A. J.; Redhead, Y.; Karim, F.; Dhami, P.; Kannambath, S.; Nuamah, R.; Volponi, A. A.; Nibali, L.; Booth, V.; D'Agostino, E. M.; Sharpe, P.
10.1101/2022.07.05.498778 — cell biology — Posted on 2022-07-05
3336 Cerebral perfusion in post-stroke aphasia and its relation to residual language abilities
Ivanova, M. V.; Pappas, I.; Inglis, B.; Pracar, A.; Herron, T. J.; Baldo, J. V.; Kayser, A. S.; D'Esposito, M.; Dronkers, N. F.
10.1101/2022.07.01.498516 — neuroscience — Posted on 2022-07-05
3339 EXORIBONUCLEASE4 integrates metabolic signals induced by osmotic stress into the circadian system
Prasetyaningrum, P.; Litthauer, S.; Vegliani, F.; Wood, M. W.; Battle, M. W.; Dickson, C.; Jones, M. A.
10.1101/2022.07.05.498805 — plant biology — Posted on 2022-07-05
3341 Distinguishing between canonical and non-canonical tRNA genes reveals that Thermococcaceae adhere to the standard archaeal tRNA gene set
van der Gulik, P. T. S.; Egas, M.; Kraaijeveld, K.; Dombrowski, N.; Groot, A. T.; Spang, A.; Hoff, W. D.; Gallie, J.
10.1101/2022.07.05.498093 — genomics — Posted on 2022-07-05
3342 Polymorphisms Predicting Phylogeny in Hepatitis B Virus (HBV)
Lourenco, J.; McNaughton, A. L.; Pley, C.; Obolski, U. L.; Gupta, S.; Matthews, P. C.
10.1101/2022.07.05.498824 — genomics — Posted on 2022-07-05
3343 Contribution of hybridization to the evolution of a derived reproductive strategy in ricefishes
Flury, J. M.; Meusemann, K.; Martin, S.; Hilgers, L.; Spanke, T.; Boehne, A.; Herder, F.; Mokodongan, D. F.; Altmueller, J.; Wowor, D.; Misof, B.; Nolte, A. W.; Schwarzer, J.
10.1101/2022.07.05.498713 — evolutionary biology — Posted on 2022-07-05
3346 The role of hippocampal CaMKII in resilience to trauma-related psychopathology
Hazra, S.; Hazra, J. D.; Bar-On, R. A.; Duan, Y.; Edut, S.; Cao, X.; Richter-Levin, G.
10.1101/2022.07.05.495828 — neuroscience — Posted on 2022-07-05
3348 Sharp cell-type-identity changes differentiate the retrosplenial cortex from the neocortex
Sullivan, K. E.; Kraus, L.; Wang, L.; Stach, T. R.; Lemire, A. L.; Clements, J.; Cembrowski, M. S.
10.1101/2022.07.04.498750 — neuroscience — Posted on 2022-07-05
3352 Sleep-dependent structural neuroplasticity after a spatial navigation task: A diffusion imaging study
Villemonteix, T.; Guerreri, M.; Deantoni, M.; Balteau, E.; Schmidt, C.; Stee, W.; Zhang, H.; Peigneux, P.
10.1101/2022.07.05.498806 — neuroscience — Posted on 2022-07-05
3354 Endogenous μ-opioid - neuropeptide Y Y1 receptor synergy silences chronic postoperative pain
Nelson, T. S.; Santos, D. F. S.; Prasoon, P.; Gralinski, M.; Allen, H. N.; Taylor, B. K.
10.1101/2022.07.05.498802 — neuroscience — Posted on 2022-07-05
3356 Polymorphic Inverted Repeats near coding genes impact chromatin topology and phenotypic traits in Arabidopsis thaliana
Arce, A. L.; Mencia, R.; Cambiagno, D. A.; Lang, P. L.; Liu, C.; Burbano, H. A.; Weigel, D.; Manavella, P. A.
10.1101/2022.07.05.498814 — plant biology — Posted on 2022-07-05
3359 Phosphorylation of aldose-6-phosphate reductase from Prunus persica leaves
Hartman, M. D.; Rojas, B. E.; Ferrero, D. M.; Leyva, A.; Duran, R.; Iglesias, A. A.; Figueroa, C. M.
10.1101/2022.07.05.498475 — plant biology — Posted on 2022-07-05
3360 A Physcomitrella PIN protein acts in spermatogenesis and sporophyte abortion
Lueth, V. M.; Rempfer, C.; Herzog, O.; Roecker, M.; Braun, M.; Decker, E. L.; Reski, R.
10.1101/2022.07.05.498815 — plant biology — Posted on 2022-07-05
3363 Tissue confinement regulates cell growth and size in epithelia
Devany, J.; Falk, M. J.; Holt, L. J.; Murugan, A.; Gardel, M.
10.1101/2022.07.04.498508 — biophysics — Posted on 2022-07-05
3364 Direct Cell Extraction of Membrane Proteins for Structure-Function Analysis
Drulyte, I.; Gutgsell, A. R.; Lloris-Garcer, P.; Liss, M.; Geschwindner, S.; Radjainia, M.; Frauenfeld, J.; Loving, R.
10.1101/2022.07.05.498330 — biophysics — Posted on 2022-07-05
3365 Meta-analysis of metagenomes via machine learning and assembly graphs reveals strain switches in Crohn's disease
Reiter, T. E.; Irber, L. C.; Gingrich, A. A.; Haynes, D.; Pierce-Ward, N. T.; Brooks, P. T.; Mizutani, Y.; Moritz, D.; Reidl, F.; Willis, A. D.; Sullivan, B. D.; Brown, C. T.
10.1101/2022.06.30.498290 — bioinformatics — Posted on 2022-07-05
3367 Sex-linked gene traffic underlies the acquisition of sexually dimorphic UV color vision in Heliconius butterflies
Chakraborty, M.; Lara, A. G.; Dang, A.; McCulloch, K. J.; Rainbow, D.; Ngo, L. T.; Solares, E. A.; Said, I.; Corbett-Detig, R.; Gilbert, L. E.; Emerson, J. J.; Briscoe, A.
10.1101/2022.07.04.498748 — evolutionary biology — Posted on 2022-07-05
3368 The contrasted impacts of grasshoppers on soil microbial activities in function of ecosystem productivity and herbivore diet
Ibanez, S.; Foulquier, A.; Brun, C.; Colace, M.-P.; Piton, G.; Bernard, L.; Gallet, C.; Clément, J.-C.
10.1101/2022.07.04.497718 — ecology — Posted on 2022-07-05
3370 The uncharacterized protein YgfB contributes to β-lactam resistance in Pseudomonas aeruginosa by inhibiting the expression of the amidase AmpDh3
Eggers, O.; Renschler, F.; Michalek, L. A.; Wackler, N.; Walter, E.; Smollich, F.; Klein, K.; Sonnabend, M.; Egle, V.; Angelov, A.; Engesser, C.; Borisova, M.; Mayer, C.; Schuetz, M.; Bohn, E.
10.1101/2022.07.05.498809 — microbiology — Posted on 2022-07-05
3371 Deep learning segmentation of the nucleus basalis of Meynert on 3T MRI
Doss, D. J.; Johnson, G. W.; Narasimhan, S.; Jiang, J. W.; Gonzalez, H. F. J.; Paulo, D. L.; Lucas, A.; Davis, K. A.; Chang, C.; Morgan, V. L.; Constantinidis, C.; Dawant, B. M.; Englot, D. J.
10.1101/2022.07.02.498556 — neuroscience — Posted on 2022-07-05
3372 Locomotor-related propriospinal V3 neurons produce primary afferent depolarization and modulate sensory transmission to motoneurons
Lin, S.; Hari, K.; Lucas-Osma, A.; Black, S.; Khatmi, A.; Fouad, K.; Gorassini, M.; Li, Y.; Fenrich, K.; Bennett, D. J.
10.1101/2022.07.04.498712 — neuroscience — Posted on 2022-07-05
3375 Tank Fouling Community Enhances Coral Microfragment Growth
Page, C.; Perry, R.; Lager, C.; Daly, J.; Bouwmeester, J.; Henley, E. M.; Hagedorn, M.
10.1101/2022.07.04.498770 — zoology — Posted on 2022-07-05
3376 Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair
Otowa, Y.; Kishimoto, S.; Saida, Y.; Yamashita, K.; Yamamoto, K.; Chandramouli, G. V.; Devasahayam, N.; Mitchell, J. B.; Krishna, M. C.; Brender, J. R.
10.1101/2022.07.04.498761 — cancer biology — Posted on 2022-07-05
3377 TRIM7 restricts Coxsackievirus and norovirus infection by detecting the C-terminalglutamine generated by 3C protease processing
Luptak, J.; Mallery, D.; Jahun, A. S.; Albecka, A.; Clift, D.; Ather, O.; Slodkowicz, G.; Goodfellow, I.; James, L.
10.1101/2022.06.28.497919 — biochemistry — Posted on 2022-07-05
3379 Mapping protein-DNA interactions with DiMeLo-seq
Maslan, A.; Altemose, N.; Mishra, R.; Marcus, J.; Brennan, L. D.; Sundararajan, K.; Karpen, G.; Straight, A. F.; Streets, A. M.
10.1101/2022.07.03.498618 — genomics — Posted on 2022-07-05
3381 The FANCC-FANCE-FANCF complex is evolutionarily conserved and regulates meiotic recombination
Singh, D. K.; Salinas-Gamboa, R.; Singh, A. K.; Walkemeir, B.; Van Leene, J.; De Jaeger, G.; Siddiqi, I.; Guerois, R.; Crismani, W.; Mercier, R.
10.1101/2022.07.05.498687 — genetics — Posted on 2022-07-05
3382 Obox4 secures zygotic genome activation upon loss of Dux
Guo, Y.; Kitano, T.; Murano, K.; Li, T. D.; Sakashita, A.; Ishizu, H.; Sato, M.; Siomi, H.
10.1101/2022.07.04.498763 — genetics — Posted on 2022-07-05
3385 A mutant bacterial O-GlcNAcase visualizes a progressive decline of protein O-GlcNAcylation in early Drosophila embryos critical for neurodevelopment
Zhang, Y.; Wang, D.; Yu, H.; Lei, X.; Meng, Y.; Zhang, N.; Chen, F.; Lv, L.; Pan, Q.; Qin, H.; Zhang, Z.; van Aalten, D. M. F.; Yuan, K.
10.1101/2022.07.04.498772 — developmental biology — Posted on 2022-07-05
3386 Multi-scale Assessment of Brain Blood Volume and Perfusion in the APP/PS1 Mouse Model of Amyloidosis
Munting, L. P.; Derieppe, M. P.; Voortman, L. M.; Khmelinskii, A.; Suidgeest, E.; Hirschler, L.; Barbier, E. L.; Denis de Senneville, B.; van der Weerd, L.
10.1101/2022.07.01.498298 — neuroscience — Posted on 2022-07-05
3388 Adapting to visuomotor rotations in stepped increments increases implicit motor learning
Modchalingam, S.; Ciccone, M.; D'Amario, S.; 't Hart, B. M.; Henriques, D. Y. P.
10.1101/2022.07.04.498746 — neuroscience — Posted on 2022-07-05
3391 Inside and outside of virus-like particles HBc and HBc/4M2e: a comprehensive study of the structure
Egorov, V. V.; Shvetsov, A. V.; Pichkur, E. B.; Shaldzhyan, A. A.; Zabrodskaya, Y. A.; Vinogradova, D. S.; Nekrasov, P. A.; Gorshkov, A. N.; Garmay, Y. P.; Kovaleva, A. A.; Stepanova, L. A.; Tsybalova, L. M.; Shtam, T. A.; Myasnikov, A. G.; Konevega, A. L.
10.1101/2022.07.04.498777 — biophysics — Posted on 2022-07-05
3397 HDAC6 inhibition partially alleviates mitochondrial trafficking defects and restores motor function in human motor neuron and zebrafish models of Charcot-Marie-Tooth Disease Type 2A
Butler, L.; Adamson, K. I.; Johnson, S. L.; Jestice, L.; Price, C. J.; Stavish, D.; Pooranachandran, N.; Tsakiridis, A.; Grierson, A.; Barbaric, I.
10.1101/2022.07.05.498819 — cell biology — Posted on 2022-07-05
3398 A species-specific lncRNA modulates the reproductive ability of the Asian tiger mosquito
Belavilas-Trovas, A.; Gregoriou, M.-E.; Tastsoglou, S.; Soukia, O.; Giakountis, A.; Mathiopoulos, K.
10.1101/2022.07.04.498273 — molecular biology — Posted on 2022-07-05
3399 Investigating genetic diversity within the most abundant and prevalent non-pathogenic leaf-associated bacteria interacting with Arabidopsis thaliana in natural habitats
Roux, F.; Sanchez-Ramirez, D.; Gibelin, C.; Mayjonade, B.; Duflos, R.; Belmonte, E.; Pailler, V.; Bartoli, C.; CARRERE, S.; Vailleau, F.
10.1101/2022.07.05.498547 — microbiology — Posted on 2022-07-05
3401 HLA-II-dependent neuroimmune changes in Group A Streptococcal Necrotizing Fasciitis
Ambigapathy, G.; Satpati, A.; Mukundan, S.; Nagamoto-Combs, K.; Combs, C. K.; Nookala, S.
10.1101/2022.07.04.495809 — neuroscience — Posted on 2022-07-05
3402 Robust capability of renal tubule fatty acid uptake from apical and basolateral membranes in physiology and disease
Kawakami, R.; Hanaoka, H.; Kanai, A.; Obinata, H.; Nakano, D.; Ikeuchi, H.; Matsui, M.; Matsuzaki, T.; Tanaka, R.; Sunaga, H.; Goto, S.; Matsui, H.; Koitabashi, N.; Saegusa, K.; Yokoyama, T.; Hiromura, K.; Nishiyama, A.; Saito, A.; Yanagita, M.; Ishii, H.; Kurabayashi, M.; Iso, T.
10.1101/2022.07.04.498762 — biochemistry — Posted on 2022-07-05
3403 Signal peptide mimicry primes Sec61 for client-selective inhibition
Rehan, S.; Tranter, D.; Sharp, P. P.; Lowe, E.; Anderl, J.; Muchamuel, T.; Abrishami, V.; Kuivanen, S.; Wenzell, N.; Jennings, A.; Kalyanaraman, C.; Craven, G. B.; Strandin, T.; Javanainen, M.; Vapalahti, O.; Jacobson, M.; McMinn, D.; Kirk, C. J.; Huiskonen, J. T.; Taunton, J.; Paavilainen, V.
10.1101/2022.07.03.498529 — biochemistry — Posted on 2022-07-05
3404 Oxonium Ion-Guided Ion Mobility-Assisted Glycoproteomics on the timsTOF Pro
Mukherjee, S.; Jankevics, A.; Busch, F.; Lubeck, M.; Zou, Y.; Kruppa, G.; Heck, A. J. R.; Scheltema, R. A.; Reiding, K.
10.1101/2022.07.04.498688 — biochemistry — Posted on 2022-07-05
3406 Electron-counting MicroED data with the K2 and K3 direct electron detectors
Clabbers, M. T. B.; Martynowycz, M. W.; Hattne, J.; Nannenga, B. L.; Gonen, T.
10.1101/2022.07.04.498775 — biochemistry — Posted on 2022-07-05
3407 Spatial and temporal origin of the third SARS-CoV-2 Outbreak in Taiwan
Tai, J.-H.; Low, Y. K.; Lin, H.-F.; Wang, T.-Y.; Lin, Y.-Y.; Foster, C.; Lai, Y.-Y.; Yeh, S.-H.; Chen, P.-J.; Wang, H.-Y.
10.1101/2022.07.04.498645 — evolutionary biology — Posted on 2022-07-05
3408 Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology
Silva, B. M.; Veras, F. P.; Gomes, G.; Cambier, S.; Silva, G.; Quadros, A.; Caetite, D.; Nascimento, D.; Silva, C.; Silva, J.; Damasceno, S.; Schneider, A.; Beretta, F.; Batah, S.; Castro, I.; Paiva, I.; Rodrigues, T.; Salina, A. C. G.; Martins, R.; Cebinelli, G.; Bibo, N.; Jorge, D.; Nakaya, H. I.; Zamboni, D. S.; Leiria, L.; Fabro, A.; Alves-Filho, J. C.; Arruda, E.; Louzada-Junior, P.; Oliveira, R.; Cunha, L. D.; Van-Mol, P.; Vanderbeke, L.; Feys, S.; Wauters, E.; Brandolini, L.; Cunha, F.; Kohl, J.; Allegretti, M.; Lambrechts, D.; Wauters, J.; Proost, P.; Cunha, T. M.
10.1101/2022.07.03.498624 — immunology — Posted on 2022-07-05
3411 HSV-1 and influenza infection induce linear and circular splicing of the long NEAT1 isoform
Friedl, M.-S.; Djakovic, L.; Kluge, M.; Hennig, T.; Whisnant, A. W.; Backes, S.; Doelken, L.; Friedel, C. C.
10.1101/2021.12.07.471605 — bioinformatics — Posted on 2022-07-05
3413 Bacterial SOS-independent Superfast Evolution of Multi-Drug Resistance
Zhang, L.; Su, Q. P.; Guan, Y.; Cheng, Y. Y.; Cokcetin, N. N.; Bottomley, A.; Robinson, A.; Harry, E.; van Oijen, A. M.; Jin, D.
10.1101/2022.03.29.486198 — microbiology — Posted on 2022-07-05
3415 Establishment of a social conditioned place preference paradigm for the study of social reward in female mice
Harda, Z.; Chroszcz, M.; Misiołek, K.; Klimczak, M.; Szumiec, Łukasz; Kaczmarczyk-Jarosz, M.; Rodriguez Parkitna, J.
10.1101/2022.03.31.486566 — animal behavior and cognition — Posted on 2022-07-05
3418 Rapid monitoring for ecological persistence
Song, C.; Simmons, B. I.; Fortin, M.-J.; Gonzalez, A.; Kaiser-Bunbury, C. N.; Saavedra, S.
10.1101/2022.07.02.498308 — ecology — Posted on 2022-07-05
3420 Neural underpinnings of action adaptation in the subthalamic nucleus.
Herz, D.; Bange, M.; Gonzalez-Escamilla, G.; Auer, M.; Muthuraman, M.; Bogacz, R.; Groppa, S.; Brown, P.
10.1101/2022.06.28.497904 — neuroscience — Posted on 2022-07-05
3425 Human genetic diversity modifies therapeutic gene editing off-target potential
Cancellieri, S.; Zeng, J.; Lin, L. Y.; Tognon, M.; Nguyen, A.; Lin, J.; Bombieri, N.; Ciuculescu, F.; Katta, V.; Tsai, S.; Armant, M.; Wolfe, S.; Giugno, R.; Bauer, D. E.; Pinello, L.
10.1101/2021.05.20.445054 — genetics — Posted on 2022-07-04
3426 Kelpwatch: A new visualization and analysis tool to explore kelp canopy dynamics reveals variable resistance and resilience to marine heat waves
Bell, T.; Cavanaugh, K. C.; Saccomanno, V. R.; Cavanaugh, K. C.; Houskeeper, H. F.; Eddy, N.; Schuetzenmeister, F.; Rindlaub, N.; Gleason, M.
10.1101/2022.07.04.498739 — ecology — Posted on 2022-07-04
3427 Biosphere functional integrity for people and Planet
Mohamed, A.; DeClerck, F.; Verburg, P.; Obura, D.; Abrams, J. F.; Zafra-Calvo, N.; Rocha, J. C.; Estrada-Carmona, N.; Fremier, A.; Jones, S. K.; Meier, I.; Sewart-Koster, B.
10.1101/2022.06.24.497294 — ecology — Posted on 2022-07-04
3428 The individuality of shape asymmetries of the human cerebral cortex
Chen, Y.-C.; Arnatkeviciute, A.; McTavish, E.; Pang, J.; Chopra, S.; Suo, C.; Fornito, A.; Aquino, K. M.; The Alzheimer's Disease Neuroimaging Initiative,
10.1101/2021.09.14.460242 — neuroscience — Posted on 2022-07-04
3429 Multi-view manifold learning of human brain statetrajectories
Busch, E. L.; Huang, J.; Benz, A.; Wallenstein, T.; Lajoie, G.; Wolf, G.; Krishnaswamy, S.; Turk-Browne, N. B.
10.1101/2022.05.03.490534 — neuroscience — Posted on 2022-07-04
3430 Modelling Instantaneous Firing Rate of DBS Target Neuronal Ensembles in Basal Ganglia and Thalamus
Tian, Y.; Murphy, M. J. H.; Steiner, L. A.; Kalia, S.; Hodaie, M.; Lozano, A.; Hutchison, W. D.; Popovic, M.; Milosevic, L.; Lankarany, M.
10.1101/2022.06.28.497834 — neuroscience — Posted on 2022-07-04
3432 Robust phylogenetic position of the enigmatic hydrozoan, Margelopsis haeckelii revealed within the family Corymorphidae
Kupaeva, D. M.; Lebedeva, T. S.; Kobrinsky, Z.; Vanwalleghem, D.; Prudkovsky, A. A.; Kremnyov, S. V.
10.1101/2021.03.30.437375 — zoology — Posted on 2022-07-04
3439 The Legionella-driven PtdIns(4)P gradient at LCV-ER membrane contact sites promotes Vap-, OSBP- and Sac1-dependent pathogen vacuole remodeling
Vormittag, S.; Hüsler, D.; Haneburger, I.; Kroniger, T.; Anand, A.; Prantl, M.; Barisch, C.; Maass, S.; Becher, D.; Letourneur, F.; Hilbi, H.
10.1101/2022.06.17.496549 — microbiology — Posted on 2022-07-04
3440 Trans-epithelial migration is essential for neutrophil activation during RSV infection
Robinson, E.; Herbert, J. A.; Palor, M.; Ren, L.; Larken, I.; Patel, A.; Moulding, D.; Cortina-Borja, M.; Smyth, R.; Smith, C. M.
10.1101/2021.10.04.463016 — immunology — Posted on 2022-07-04
3442 Saturated Fat Impairs Circadian Transcriptomics through Histone Modification of Enhancers
Pillon, N. J.; Sardon Puig, L.; Altintas, A.; Kamble, P.; Casani, S.; Gabriel, B. M.; Barres, R.; Conesa, A.; Chibalin, A. V.; Naslund, E.; Krook, A.; Zierath, J. R.
10.1101/2021.02.23.432336 — physiology — Posted on 2022-07-04
3447 The role of proton in a eukaryotic zinc transporter
Zhang, S.; Fu, C.; Luo, Y.; Xie, Q.; Xu, T.; Sun, Z.; Su, Z.; Zhou, X.
10.1101/2022.06.29.497979 — biochemistry — Posted on 2022-07-04
3451 Antibody repertoire gene usage is explained by common genetic variants in the immunoglobulin heavy chain locus
Rodriguez, O. L.; Safonova, Y.; Silver, C. A.; Shields, K.; Gibson, W. S.; Kos, J. T.; Tieri, D.; Ke, H.; Jackson, K. J. L.; Boyd, S. D.; Smith, M.; Marasco, W.; Watson, C. T.
10.1101/2022.07.04.498729 — genomics — Posted on 2022-07-04
3453 Impact of storage on starch digestibility and texture of a high-amylose wheat bread
Corrado, M.; Zafeiriou, P.; Ahn-Jarvis, J. H.; Savva, G. M.; Edwards, C. H.; Hazard, B. A.
10.1101/2022.07.04.498686 — biochemistry — Posted on 2022-07-04
3454 Identification of a sensory neuron Cav2.3 inhibitor within a new superfamily of macro-conotoxins
Hackney, C. M.; Florez Salcedo, P.; Mueller, E.; Kjelgaard, L. D.; Watkins, M.; Zachariassen, L. G.; McArthur, J. R.; Adams, D. J.; Kristensen, A. S.; Olivera, B.; Finol-Urdaneta, R. K.; Safavi, H.; Morth, J. P.; Ellgaard, L.
10.1101/2022.07.04.498665 — biochemistry — Posted on 2022-07-04
3456 Genetic stock identification reveals greater use of an oceanic feeding ground around the Faroe Islands by multi-sea winter Atlantic salmon.
O'Sullivan, R. J.; Ozerov, M.; Bolstad, G. H.; Gilbey, J.; Jacobsen, J. A.; Erkinaro, J.; Rikardsen, A. H.; Hindar, K.; Aykanat, T.
10.1101/2022.07.04.498682 — ecology — Posted on 2022-07-04
3457 Eco-evolutionary drivers of avian migratory connectivity
Fattorini, N.; Costanzo, A.; Romano, A.; Rubolini, D.; Baillie, S.; Bairlein, F.; Spina, F.; Ambrosini, R.
10.1101/2022.07.04.497586 — ecology — Posted on 2022-07-04
3459 Directed Differentiation of Human iPSCs to Functional Ovarian Granulosa-Like Cells via Transcription Factor Overexpression
Smela, M. P.; Kramme, C.; Fortuna, P. R.; Adams, J.; Dong, E.; Kobayashi, M.; Brixi, G.; Tysinger, E.; Kohman, R. E.; Shioda, T.; Chatterjee, P.; Church, G. M.
10.1101/2022.07.04.498717 — developmental biology — Posted on 2022-07-04
3461 Monoallelically-expressed Noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression
Hao, Q.; Liu, M.; Daulatabad, S. V.; Gaffari, S.; Srivastava, R.; Song, Y. J.; Bhaskar, S.; Moitra, A.; Mangan, H.; Tseng, E.; Gilmore, R. B.; Frier, S. M.; Chen, X.; Wang, C.; Huang, S.; Chamberlain, S.; Jin, H.; Korlach, J.; McStay, B.; Sinha, S.; Janga, S. C.; Prasanth, S.; Prasanth, K. V.
10.1101/2022.07.04.498693 — cell biology — Posted on 2022-07-04
3466 Evolutionary Diversification of Methanotrophic Ca. Methanophagales (ANME-1) and Their Expansive Virome
Laso-Perez, R.; Wu, F.; Cremiere, A.; Speth, D. R.; Magyar, J. S.; Krupovic, M.; Orphan, V. J.
10.1101/2022.07.04.498658 — microbiology — Posted on 2022-07-04
3467 Executed and imagined grasping movements can be decoded from lower dimensional representation of distributed non-motor brain areas.
Ottenhoff, M. C.; Verwoert, M.; Goulis, S.; Colon, A.; Wagner, L.; Tousseyn, S.; van Dijk, J. P.; Kubben, P.; Herff, C.
10.1101/2022.07.04.498676 — neuroscience — Posted on 2022-07-04
3469 Single-cell multi-omics enabled discovery of alkaloid biosynthetic pathway genes in the medical plant Catharanthus roseus
Li, C.; Wood, J. C.; Vu, A. H.; Hamilton, J. P.; Rodriguez Lopez, C. E.; Payne, R. M. E.; Serna Guerrero, D. A.; Yamamoto, K.; Vaillancourt, B.; Caputi, L.; O'Connor, S. E.; Buell, C. R.
10.1101/2022.07.04.498697 — plant biology — Posted on 2022-07-04
3470 Receptor levels determine binding affinity of WNT-3A to Frizzled 7 in a colorectal cancer model
Graetz, L.; Sajkowska-Kozielewicz, J. J.; Wesslowski, J.; Petzold, K.; Davidson, G.; Schulte, G.; Kozielewicz, P.
10.1101/2022.07.04.498383 — pharmacology and toxicology — Posted on 2022-07-04
3471 Goat PRP14 (gPRP14) has xeno-antigenic properties and works as a vaccine in preclinical models of cancer.
Minucci, S.; Bussolati, B.; Massa, P.; Brossa, A.; Ravasio, R.; Saadeldin, M.; Degani, G.; Papadimitriou, E.; Saadeldin, A.; Salvaggio, A.; Visentin, C.; Rizzi, G.; Ricagno, S.; Popolo, L.; Vanoni, M. A.; Pelicci, P. G.
10.1101/2022.07.04.498594 — cancer biology — Posted on 2022-07-04
3473 Effect of Charge Distribution on the Dynamics of Polyampholytic Disordered Proteins
Devarajan, D. S.; Rekhi, S.; Nikoubashman, A.; Kim, Y. C.; Howard, M. P.; Mittal, J.
10.1101/2022.07.04.498718 — biophysics — Posted on 2022-07-04
3478 Kelpwatch: A new visualization and analysis tool to explore kelp canopy dynamics reveals variable resistance and resilience to marine heat waves
Bell, T.; Cavanaugh, K. C.; Saccomanno, V. R.; Cavanaugh, K. C.; Houskeeper, H. F.; Eddy, N.; Schuetzenmeister, F.; Rindlaub, N.; Gleason, M.
10.1101/2022.07.04.498739 — ecology — Posted on 2022-07-04
3479 Mimicking orchids lure bees from afar with exaggerated ultraviolet signals
Scaccabarozzi, D.; Lunau, K.; Guzzetti, L.; Cozzolino, S.; Dyer, A. G.; Tommasi, N.; Biella, P.; Galimberti, A.; Labra, M.; Bruni, I.; Pecoraro, L.; Pattarini, G.; Brundrett, M.; Gagliano, M.
10.1101/2022.07.04.498711 — ecology — Posted on 2022-07-04
3484 Shear stress induced KLF4 is a key determinant in AVM pathogenesis
Banerjee, K.; Gahn, J.; Lin, Y.; Lei, X.; Gupta, P.; Graupera, M.; Schwartz, M. A.; Ola, R.
10.1101/2022.07.04.498236 — molecular biology — Posted on 2022-07-04
3488 Mucosal administration of anti-bacterial antibody provides long-term cross-protection against Pseudomonas aeruginosa respiratory infection
Pitiot, A.; Ferreira, M.; Parent, C.; Boisseau, C.; Cortes, M.; Bouvart, L.; Paget, C.; Heuze-Vourc'h, N.; Secher, T.
10.1101/2022.07.04.498699 — immunology — Posted on 2022-07-04
3491 Power spectrum and critical exponents in the 2D stochastic Wilson Cowan model
Apicella, I.; Scarpetta, S.; de Arcangelis, L.; Sarracino, A.; de Candia, A.
10.1101/2022.07.04.498640 — neuroscience — Posted on 2022-07-04
3492 Saltatory axonal conduction in the avian retina
Block, C. T.; Ahlers, M. T.; Puller, C.; Manackin, M.; Pradhan, D. R.; Greschner, M.
10.1101/2022.07.04.498722 — neuroscience — Posted on 2022-07-04
3493 Upregulation of TLR4/MyD88 pathway in alcohol-induced Wernicke's encephalopathy: findings in preclinical models and in a postmortem human case
Moya, M.; Escudero, B.; Gomez-Blazquez, E.; Rebolledo-Poves, A. B.; Lopez-Gallardo, M.; Guerrero, C.; Marco, E. M.; Orio, L.
10.1101/2022.06.30.497714 — neuroscience — Posted on 2022-07-04
3494 Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation
Juyoux, P.; Galdadas, I.; Gobbo, D.; Tully, M.; Gervasio, F. L.; Pellegrini, E.; Bowler, M. W.
10.1101/2022.07.04.498667 — biophysics — Posted on 2022-07-04
3498 Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization
Morichaud, Z.; Trapani, S.; Vishwakarma, R.; Chaloin, L.; Lionne, C.; Lai-Kee-Him, J.; Bron, P.; Brodolin, K.
10.1101/2022.07.04.498644 — molecular biology — Posted on 2022-07-04
3501 Local neuroplasticity in adult glaucomatous visual cortex
Carvalho, J. C. O.; Invernizzi, A.; Martins, J.; Renken, R.; Cornelissen, F.
10.1101/2022.07.04.498672 — neuroscience — Posted on 2022-07-04
3507 Vast human gut virus diversity uncovered by combined short- and long-read sequencing
Chen, W.; Chen, J.; Sun, C.; Dong, Y.; Jin, M.; Lai, S.; Jia, L.; Zhao, X.; Gao, N. L.; Liu, Z.; Bork, P.; Zhao, X.-M.
10.1101/2022.07.03.498593 — bioinformatics — Posted on 2022-07-04
3508 CometAnalyser: a user-friendly, open-source deep-learning microscopy tool for quantitative comet assay analysis.
Beleon, A.; Pignatta, S.; Arienti, C.; Carbonaro, A.; Horvath, P.; Martinelli, G.; Castellani, G.; Tesei, A.; Piccinini, F.
10.1101/2022.07.04.498642 — bioengineering — Posted on 2022-07-04
3509 Afadin and zyxin contribute to coupling between cell junctions and contractile actomyosin networks during apical constriction
Slabodnick, M. M.; Tintori, S. C.; Prakash, M.; Higgins, C. D.; Chen, A. H.; Cupp, T. D.; Wong, T.; Bowie, E.; Jug, F.; Goldstein, B.
10.1101/2022.07.04.498649 — genetics — Posted on 2022-07-04
3512 Fifty years of reduction in sulphur deposition drives recovery in soil pH and plant communities
Seaton, F. M.; Robinson, D. A.; Monteith, D.; Lebron, I.; Buerkner, P.; Tomlinson, S.; Emmett, B. A.; Smart, S. M.
10.1101/2022.07.04.498654 — ecology — Posted on 2022-07-04
3516 Odd skipped-related 1 controls the pro-regenerative response of Fibro-Adipogenic Progenitors
Kotsaris, G.; Qazi, T. H.; Bucher, C. H.; Poehle-Kronawitter, S.; Ugorets, V.; Jarassier, W.; Boerno, S.; Timmermann, B.; Giesecke-Thiel, C.; Vallecillo-Garcia, P.; Economides, A. N.; Le Grand, F.; Knaus, P.; Geissler, S.; Stricker, S.
10.1101/2022.07.04.498663 — developmental biology — Posted on 2022-07-04
3517 A parasitic fungus employs mutated eIF4A to survive on rocaglate-synthesizing Aglaia plants
Chen, M.; Kumakura, N.; Muller, R.; Shichino, Y.; Nishimoto, M.; Mito, M.; Gan, P.; Ingolia, N. T.; Shirasu, K.; Ito, T.; Iwasaki, S.
10.1101/2022.07.04.498659 — molecular biology — Posted on 2022-07-04
3518 Gamma-interferon-inducible lysosomal thiol reductase maintains cardiac immuno-metabolic homeostasis in heart failure
Li, M.; Wang, J.; Qian, Q.; Chen, B.; Zhang, Z.; Zhang, Y.; Hall, D. D.; Abel, E. D.; Song, L.-S.; Yang, L.
10.1101/2022.07.03.498477 — molecular biology — Posted on 2022-07-04
3520 Atypical intrinsic neural timescales in temporal lobe epilepsy
Xie, K.; Royer, J.; Lariviere, S.; Rodriguez-Cruces, R.; Vos de Wael, R.; Park, B.-y.; Tavakol, S.; DeKraker, J.; Abdallah, C.; Caciagli, L.; Bassett, D. S.; Bernasconi, A.; Bernasconi, N.; Frauscher, B.; Concha, L.; Bernhardt, B.
10.1101/2022.07.01.498416 — neuroscience — Posted on 2022-07-04
3521 Neural population dynamics in dorsal premotor cortex underlying a reach decision
Boucher, P. O.; Wang, T.; Carceroni, L.; Kane, G.; Shenoy, K. V.; Chandrasekaran, C.
10.1101/2022.06.30.497070 — neuroscience — Posted on 2022-07-04
3522 A diverse network of pericoerulear neurons control arousal states
Luskin, A. T.; Li, L.; Fu, X.; Barcomb, K.; Blackburn, T.; Li, E. M.; Rana, A.; Simon, R. C.; Sun, L.; Murry, A. D.; Golden, S. A.; Stuber, G. D.; Ford, C. P.; Gu, L.; Bruchas, M. R.
10.1101/2022.06.30.498327 — neuroscience — Posted on 2022-07-04
3523 Brain dynamics predictive of response to psilocybin for treatment-resistant depression
Vohryzek, J.; Cabral, J.; Lord, L.-D.; Fernandes, H. M.; Roseman, L.; Nutt, D. J.; Carhart-Harris, R. L.; Deco, G.; Kringelbach, M. L.
10.1101/2022.06.30.497950 — neuroscience — Posted on 2022-07-04
3524 Assessment of Human Expertise in First-Person Shooter Games
Donovan, I.; Saul, M. A.; DeSimone, K.; Listman, J. B.; Mackey, W. E.; Heeger, D. J.
10.1101/2022.06.30.498231 — neuroscience — Posted on 2022-07-04
3533 FOXA2 controls the antioxidant response in FH-deficient cells independent of NRF2
Rogerson, C.; Sciacovelli, M.; Maddalena, L. A.; Valcarcel-Jimenez, L.; Schmidt, C.; Yang, M.; Ivanova, E.; Kent, J.; Cheeseman, D.; Carroll, J. S.; Kelsey, G.; Frezza, C.
10.1101/2022.07.04.498412 — cancer biology — Posted on 2022-07-04
3535 Tissue-specific regulation of gene expression via unproductive splicing
Mironov, A.; Vlasenok, M.; Margasyuk, S.; Mironov, A. A.; Pervouchine, D. D.
10.1101/2022.07.03.498634 — bioinformatics — Posted on 2022-07-04
3542 LUZP1 regulates the constriction velocity of the contractile ring during cytokinesis
Hyodo, T.; ASANO-INAMI, E.; Ito, S.; Sugiyama, M.; Nawa, A.; Rahman, M. L.; Hasan, M. N.; Mihara, Y.; Lam, V. Q.; Karnan, S.; Ota, A.; Tsuzuki, S.; Hamaguchi, M.; Hosokawa, Y.; Konishi, H.
10.1101/2022.07.04.498656 — cell biology — Posted on 2022-07-04
3543 Network of hotspot interactions cluster tau amyloid folds
Mullapudi, V.; Vacquer-Alicea, J.; Bommareddy, V.; Vega, A. R.; Ryder, B. D.; White, C. L. A.; Diamond, M. I.; Joachimiak, L. A.
10.1101/2022.07.01.498342 — neuroscience — Posted on 2022-07-04
3545 β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma
Mohan, D. R.; Borges, K. S.; Finco, I.; LaPensee, C. R.; Rege, J.; Solon, A. L.; Little, D. W.; Else, T.; Almeida, M. Q.; Dang, D.; Haggerty-Skeans, J.; Apfelbaum, A. A.; Vinco, M.; Wakamatsu, A.; Mariani, B. M. P.; Amorin, L.; Latronico, A. C.; Mendonca, B. B.; Zerbini, M. C. N.; Lawlor, E. R.; Ohi, R.; Auchus, R. J.; Rainey, W. E.; Marie, S. K. N.; Giordano, T. J.; Venneti, S.; Fragoso, M. C. B. V.; Breault, D. T.; Lerario, A. M.; Hammer, G. D.
10.1101/2022.07.02.497654 — cancer biology — Posted on 2022-07-04
3546 Ablative radiotherapy improves survival in autochthonous cancer mouse models
Schmidt, D. R.; Gramatikov, I. M. T.; Sheen, A.; Williams, C. L.; Hurwitz, M.; Dodge, L. E.; Holupka, E.; Kiger, W. S.; Cornwall-Brady, M. R.; Huang, W.; Mak, H. H.; Cormier, K.; Condon, C.; Wittrup, D.; Yilmaz, O. H.; Stevenson, M. A.; Down, J. D.; Floyd, S. R.; Roper, J.; Vander Heiden, M. G.
10.1101/2022.07.01.498353 — cancer biology — Posted on 2022-07-04
3554 Pixel size limit of the PRIMA implants: from humans to rodents and back
Wang, B.-Y.; Chen, Z. C.; Bhuckory, M.; Kochnev Goldstein, A.; Palanker, D.
10.1101/2022.06.29.498181 — bioengineering — Posted on 2022-07-04
3555 A crosstalk between hepcidin and IRE/IRP pathways controls ferroportinexpression and determines serum iron levels in mice
Charlebois, E.; Fillebeen, C.; Katsarou, A.; Rabinovich, A.; Wisniewski, K.; Venkataramani, V.; Michalke, B.; Velentza, A.; Pantopulos, K.
10.1101/2021.10.29.466457 — immunology — Posted on 2022-07-04
3561 GJA1 Depletion Causes Ciliary Defects by Affecting Rab11 Trafficking to the Ciliary Base
Jang, D. G.; Kwon, K. Y.; Kweon, Y. C.; Kim, B.-g.; Myung, K.; Lee, H.-S.; Young Park, C.; Kwon, T.; Park, T. J.
10.1101/2020.11.13.381764 — developmental biology — Posted on 2022-07-03
3563 Emotional Vocalizations Alter Behaviors and Neurochemical Release into the Amygdala
Ghasemahmad, Z.; Mrvelj, A.; Panditi, R.; Sharma, B.; Perumal, K. D.; Wenstrup, J. J.
10.1101/2022.07.02.498564 — neuroscience — Posted on 2022-07-04
3566 Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga
Ishii, Y.; Ishii, H.; Kuroha, T.; Yokoyama, R.; Deguchi, R.; Nishitani, K.; Minagawa, J.; Kawata, M.; Takahashi, S.; Maruyama, S.
10.1101/2022.07.03.498615 — evolutionary biology — Posted on 2022-07-03
3568 FMRI complexity correlates with tau-PET in Late-Onset and Autosomal Dominant Alzheimer's Disease
Jann, K.; Boudreau, J.; Albrecht, D.; Cen, S. Y.; Cabeen, R. P.; Ringman, J. M.; Wang, D. J.; Alzheimer's Disease Neuroimaging Initiative (ADNI),
10.1101/2022.06.29.498174 — neuroscience — Posted on 2022-07-03
3569 WiChR, a highly potassium selective channelrhodopsin for low-light two-photon neuronal inhibition
Vierock, J.; Peter, E.; Grimm, C.; Rozenberg, A.; Castro Scalise, A. G.; Augustin, S.; Tanese, D.; Forget, B. C.; Emiliani, V.; Beja, O.; Hegemann, P.
10.1101/2022.07.02.498568 — neuroscience — Posted on 2022-07-03
3572 Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga
Ishii, Y.; Ishii, H.; Kuroha, T.; Yokoyama, R.; Deguchi, R.; Nishitani, K.; Minagawa, J.; Kawata, M.; Takahashi, S.; Maruyama, S.
10.1101/2022.07.03.498615 — evolutionary biology — Posted on 2022-07-03
3573 The cost of information acquisition by natural selection
McGee, R. S.; Kosterlitz, O.; Kaznatcheev, A.; Kerr, B.; Bergstrom, C. T.
10.1101/2022.07.02.498577 — evolutionary biology — Posted on 2022-07-03
3575 Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis
SanMiguel, J. M.; Eudy, E.; Loberg, M. A.; Young, K. A.; Mistry, J. J.; Schwartz, L. S.; Stearns, T.; Challen, G. A.; Trowbridge, J. J.
10.1101/2022.07.03.498502 — cell biology — Posted on 2022-07-03
3579 Multimodal deep neural decoding of visual object representation in humans
Watanabe, N.; Miyoshi, K.; Jimura, K.; Shimane, D.; Keerativittayayut, R.; Nakahara, K.; Takeda, M.
10.1101/2022.04.06.487262 — neuroscience — Posted on 2022-07-03
3581 Adaptive Unscented Kalman Filter for Neuronal State and Parameter Estimation
Azzalini, L. J.; Crompton, D.; D'Eleuterio, G. M. T.; Skinner, F.; Lankarany, M.
10.1101/2022.06.29.497821 — neuroscience — Posted on 2022-07-03
3584 Directed growth and fusion of membrane-wall microdomains requires CASP-mediated inhibition and displacement of secretory foci
Barbosa, I. R.; De Bellis, D.; Fluckiger, I.; Bellani, E.; Grange-Guermente, M.; Hematy, K.; Geldner, N.
10.1101/2022.07.03.498613 — plant biology — Posted on 2022-07-03
3585 A hair cell-specific peroxidase coordinates stomatal and prickle hair cell size to optimize epidermal cell functionality in grasses
Nunes, T. D.; Slawinska, M. W.; Zhang, D.; Redt, L.; Sibout, R.; Vogel, J. P.; Jesenofsky, B.; Lindner, H.; Raissig, M. T.
10.1101/2022.07.03.498611 — plant biology — Posted on 2022-07-03
3586 In-depth investigation of microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian
Fan, X.; Zhang, W.; Zhang, K.; Zhang, J.; Long, Q.; Wu, Y.; Zhang, K.; Zhu, L.; Chen, D.; Guo, R.
10.1101/2022.07.03.498592 — pathology — Posted on 2022-07-03
3587 Genomic heterogeneity in pancreatic cancer organoids and its stability with culture
Usman, O.; Zhang, L.; Xie, G.; Kocher, H. M.; Hwang, C.-i.; Wang, Y. J.; Mallory, X. F.; Irianto, J.
10.1101/2022.07.03.498602 — cancer biology — Posted on 2022-07-03
3588 RORc expressing immune cells support pro-tumorigenic functions of tertiary lymphoid structures
Cinnamon, E.; Stein, I.; Zino, E.; Rabinovich, S.; Shovman, Y.; Schlesinger, Y.; Salame, T. M.; Reich-Zeliger, S.; Lotem, M.; Ben-Neriah, Y.; Parnas, O.; Pikarsky, E.
10.1101/2022.07.02.498540 — cancer biology — Posted on 2022-07-03
3594 A novel hyper-parameter can increase the prediction accuracy in a single-step genetic evaluation
Neshat, M.; Lee, S.; Momin, M. M.; Truong, B.; van der Werf, J. H. J.; Lee, S. H.
10.1101/2022.07.03.498620 — genomics — Posted on 2022-07-03
3595 Pollen sequencing reveals barriers and aberrant patterns of recombination in interspecific tomato hybrids
Fuentes, R. R.; Nieuwenhuis, R.; Chouaref, J.; Hesselink, T.; van Dooijeweert, W.; van den Broeck, H. C.; Schijlen, E.; Fransz, P.; Stam, M.; de Jong, H.; Trivino, S. D.; de Ridder, D.; van Dijk, A. D. J.; Peters, S. A.
10.1101/2022.07.02.498571 — genomics — Posted on 2022-07-03
3596 Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe
Kerner, G.; Neehus, A.-L.; Abel, L.; Casanova, J.-L.; Patin, E.; Laval, G.; Quintana-Murci, L.
10.1101/2022.07.02.498543 — genetics — Posted on 2022-07-03
3597 Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos
McCoy, R. C.; Summers, M. C.; McCollin, A.; Ottolini, C. S.; Ahuja, K.; Handyside, A. H.
10.1101/2022.07.03.498614 — genetics — Posted on 2022-07-03
3599 Weight cycling induces innate immune memory in adipose tissue macrophages
Caslin, H. L.; Cottam, M. A.; Pinon, J. M.; Boney, L. Y.; Hasty, A. H.
10.1101/2022.07.02.498553 — immunology — Posted on 2022-07-03
3607 Bayesian inference in ring attractor networks
Kutschireiter, A.; Basnak, M. A.; Drugowitsch, J.
10.1101/2021.12.17.473253 — neuroscience — Posted on 2022-07-03
3608 Fetal imidacloprid causes ASD-like impairment of biological motion perception in neonatal chicks
Matsushima, T.; Miura, M.; Patzke, N.; Toji, N.; Wada, K.; Ogura, Y.; Homma, K. J.; Sgado, P.; Vallortigara, G.
10.1101/2022.05.19.492744 — pharmacology and toxicology — Posted on 2022-07-03
3613 Promoting Fc-Fc interactions between anti-capsular antibodies provides strong complement-dependent immune protection against Streptococcus pneumoniae
Aguinagalde, L.; den Boer, M. A.; Castenmiller, S.; Zwarthoff, S.; de Haas, C. J. C.; Aerts, P.; Beurskens, F. J.; Schuurman, J.; Heck, A. J. R.; Kessel, K. V.; Rooijakkers, S.
10.1101/2022.01.21.477211 — microbiology — Posted on 2022-07-03
3615 In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation
Savya, S. P.; Li, F.; Lam, S.; Wellman, S. M.; Stieger, K. C.; Chen, K.; Eles, J. R.; Kozai, T. D. Y.
10.1101/2022.07.01.498483 — bioengineering — Posted on 2022-07-03
3618 GIP receptor reduces osteoclast activity and improves osteoblast survival by activating multiple signaling pathways
Hansen, M. S.; Soe, K.; Christensen, L. L.; Fernandez-Guerra, P.; Hansen, N. W.; Wyatt, R. A.; Martin, C.; Hardy, R. S.; Anderson, T. L.; Olesen, J. B.; Overgaard, S.; Hartmann, B.; Rosenkilde, M. M.; Kassem, M.; Rauch, A.; Gorvin, C. M.; Frost, M.
10.1101/2022.07.02.498420 — cell biology — Posted on 2022-07-03
3621 Helping can be driven by non-affective cues in rat
Vieira Sugano, Y. Y.; Shan, H.; Molasky, N.; Mason, P.
10.1101/2022.07.01.498150 — neuroscience — Posted on 2022-07-03
3622 Decision-making processes in perceptual learning depend on effectors
Ivanov, V.; Manenti, G.; Sudmann, S. S.; Kagan, I.; Schwiedrzik, C. M.
10.1101/2022.06.29.498152 — neuroscience — Posted on 2022-07-03
3625 ProSelfLC: Progressive Self Label Correction Towards A Low-Temperature Entropy State
Wang, X.; Hua, Y.; Kodirov, E.; Mukherjee, S. S.; Clifton, D. A.; Robertson, N. M.
10.1101/2022.07.01.498447 — bioinformatics — Posted on 2022-07-03
3626 3D Printed Neural Tissues with in situ Optical Dopamine Sensors
Li, J.; Reimers, A.; Dang, K. M.; Brunk, M. G. K.; Drewes, J.; Hirsch, U. M.; Willems, C.; Schmelzer, C. E. H.; Groth, T.; Nia, A. S.; Feng, X.; Schütt, F.; Sacher, W. D.; Adelung, R.; Poon, J. K. S.
10.1101/2022.07.01.498382 — bioengineering — Posted on 2022-07-03
3634 A modular platform for bioluminescent RNA tracking
Ng, K. K.; Cole, K. H.; Halbers, L. H.; Chen, C.; Barhoosh, A. A.; Reid-McLaughlin, E.; Metcalfe, M.; Kent, A. D.; Steward, O.; Luptak, A.; Prescher, J. A.
10.1101/2022.07.02.498144 — molecular biology — Posted on 2022-07-03
3635 Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain and placenta
Husso, A.; Pessa-Morikawa, T.; Koistinen, V. M.; Karkkainen, O.; Lahti, L.; Iivanainen, A.; Hanhineva, K.; Niku, M.
10.1101/2022.07.01.498433 — microbiology — Posted on 2022-07-03
3646 Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission
Cuhadar, U.; Calzado-Reyes, L.; Pascual-Caro, C.; Aberra, A. S.; Aggarwal, A.; Podgorski, K.; Hoppa, M. B.; de Juan-Sanz, J.
10.1101/2022.07.03.498586 — neuroscience — Posted on 2022-07-03
3652 Reducing chlorophyll level in seed filling stages results in higher seed nitrogen without impacting canopy carbon assimilation
Cho, Y. B.; Boyd, R. A.; Ren, Y.; Lee, M.; Jones, S. I.; Ruiz Vera, U. M.; McGrath, J. M.; Masters, M. D.; Ort, D. R.
10.1101/2022.07.01.498509 — plant biology — Posted on 2022-07-03
3654 Complement receptor C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain
Quadros, A. U.; Maganin, A. G. d. M.; Silva, E. A.; Damasceno, S.; Cavallini, M. C. M.; Davoli-Ferreira, M.; Lopes, A. H.; Sagar, D. R.; Brandolini, L.; Lee, S. H.; Alves-Filho, J. C.; Cunha, F.; Berta, T.; Koehl, J.; Alegretti, M.; Chapman, V.; Cunha, T. M.
10.1101/2022.07.01.498487 — pharmacology and toxicology — Posted on 2022-07-03
3656 Electric Field Responsive Nanotransducers for Glioblastoma
Jain, A.; Jobson, I.; Griffin, M.; Rahman, R.; Smith, S.; Rawson, F. J.
10.1101/2022.07.01.498417 — cancer biology — Posted on 2022-07-03
3658 Humanized NBSGW PDX Models of Disseminated Ovarian Cancer Recapitulate Key Aspects of the Tumor Immune Environment within the Peritoneal Cavity
Steinkamp, M. P.; Lagutina, I.; Brayer, K. J.; Schultz, F.; Burke, D.; Pankratz, V. S.; Adams, S. F.; Hudson, L. G.; Ness, S. A.; Wandinger-Ness, A.
10.1101/2022.07.01.498335 — cancer biology — Posted on 2022-07-03
3661 Injectable hydrogel embedded with mesenchymal stem cells repairs severe spinal cord injury
Chen, X.; Lu, W.; Zuo, Y.; Ye, J.; Li, X.; Wu, Z.; Jin, S.; Cai, W.; Abdelrahman, Z.; Zhang, T.; Yu, B.; Gu, X.; Chen, Z.; Wang, X.
10.1101/2022.07.01.498514 — bioengineering — Posted on 2022-07-03
3666 A novel Smg6 mouse model reveals regulation of circadian period and daily CRY2 accumulation through the nonsense-mediated mRNA decay pathway
Katsioudi, G.; Dreos, R.; Arpa, E. S.; Gaspari, S.; Liechti, A.; Sato, M.; Gabriel, C. H.; Kramer, A.; Brown, S. A.; Gatfield, D.
10.1101/2022.07.01.498406 — genetics — Posted on 2022-07-03
3667 Clonal breeding strategies to harness heterosis: insights from stochastic simulation
Labroo, M. R.; Endelman, J. B.; Gemenet, D. C.; Werner, C. R.; Gaynor, R. C.; Covarrubias-Pazaran, G. E.
10.1101/2022.07.01.497810 — genetics — Posted on 2022-07-03
3669 Genomic signals of local adaptation and hybridization in Asian white birch
Nocchi, G.; Wang, J.; Yang, L.; Ding, J.; Gao, Y.; Buggs, R. J. A.; Wang, N.
10.1101/2022.07.01.498522 — evolutionary biology — Posted on 2022-07-03
3670 Predicting leaf traits across functional groups using reflectance spectroscopy
Kothari, S.; Beauchamp-Rioux, R.; Blanchard, F.; Crofts, A. L.; Girard, A.; Guilbeault-Mayers, X.; Hacker, P. W.; Pardo, J.; Schweiger, A. K.; Demers-Thibeault, S.; Bruneau, A.; Coops, N. C.; Kalacska, M.; Vellend, M.; Laliberte, E.
10.1101/2022.07.01.498461 — ecology — Posted on 2022-07-03
3671 The mosquito vectors that sustained malaria transmission during the Magude project despite the combined deployment of indoor residual spraying, insecticide-treated nets and mass-drug administration.
Fernandez Montoya, L.; Marti-Soler, H.; Maquina, M.; Comiche, K.; Cuamba, I.; Alafo, C.; Koekemoer, L. L.; Sherrard-Smith, E.; Bassat, Q.; Galatas, B.; Aide, P.; Cuamba, N.; Jotamo, D.; Saute, F.; Paaijmans, K.
10.1101/2022.07.01.498466 — ecology — Posted on 2022-07-03
3673 Dendrite architecture determines mitochondrial distribution patterns in vivo
Donovan, E. J.; Agrawal, A.; Liberman, N.; Kalai, J.; Chua, J. N.; Koslover, E. F.; Barnhart, E. L.
10.1101/2022.07.01.497972 — cell biology — Posted on 2022-07-03
3676 Molecular glue CELMoD compounds are allosteric regulators of cereblon conformation
Watson, E. R.; Novick, S. J.; Matyskiela, M. E.; Chamberlain, P. P.; de la Pena, A. H.; Zhu, J.-Y.; Tran, E.; Griffin, P. R.; Wertz, I. E.; Lander, G. C.
10.1101/2022.07.02.498551 — molecular biology — Posted on 2022-07-03
3683 Modeling Hippocampal Spatial Cells in Rodents navigating in 3D environments
Aziz, A.; Patil, B. K.; Lakshmikanth, K.; Peesapati, S. H.; Mukhopadhyay, A.; Chakravarthy, V. S.
10.1101/2022.06.30.498249 — neuroscience — Posted on 2022-07-03
3688 Backbone amides are key determinants of Cl- selectivity in CLC ion channels
Leisle, L.; Lam, K.; Dehghanighahnaviyeh, S.; Fortea, E.; Galpin, J. D.; Ahern, C. A.; Tajkhorshid, E.; Accardi, A.
10.1101/2022.07.01.498497 — biophysics — Posted on 2022-07-03
3693 Synergizing exchangeable fluorophore labels for multi-target STED microscopy
Glogger, M.; Wang, D.; Kompa, J.; Balakrishnan, A.; Hiblot, J.; Barth, H.-D.; Johnsson, K.; Heileman, M.
10.1101/2022.07.02.498450 — biophysics — Posted on 2022-07-03
3697 pH Effect on Ligand Binding to an Enzyme Active Site
Singh, K.; Muttathukattil, A. N.; Singh, P. C.; Reddy, G.
10.1101/2022.07.01.498456 — biophysics — Posted on 2022-07-03
3699 Development of nanobodies as theranostic agents against CMY-2-like class C β-lactamases
Cawez, F.; Mercuri, P. S.; Yanez, F. M.; Maalouf, R.; Vandevenne, M.; Kerff, F.; Guerin, V.; Mainil, J. G.; Thiry, D.; Salmon, M.; Vanderplasschen, A.; Lafaye, P.; Ayme, G.; Bogaerts, P.; Dumoulin, M.; Galleni, M.
10.1101/2022.07.01.498528 — biochemistry — Posted on 2022-07-03
3702 A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology
Campbell, B. F.; Dittmann, A.; Dreier, B.; Plückthun, A.; Tyagarajan, S. K.
10.1101/2022.06.30.498253 — neuroscience — Posted on 2022-07-03
3705 CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice
Greco, G.; Rock, M.; Amontree, M.; Lanfranco, M. F.; Korthas, H.; Hong, S. H.; Turner, R. S.; Rebeck, G. W.; Conant, K.
10.1101/2022.06.29.498148 — neuroscience — Posted on 2022-07-02
3706 α1 adrenergic receptor - PKC - Pyk2 - Src signaling boosts L-type Ca2+ channel Cav1.2 activity and long-term potentiation in rodents
Man, K. N. M.; Henderson, P. B.; Kim, K.; Shi, M.; Zhang, M.; Nieves-Cintron, M.; Navedo, M. F.; Horne, M. C.; Hell, J. W.
10.1101/2022.07.01.498400 — neuroscience — Posted on 2022-07-03
3708 Stress-induced plasticity of a novel CRH GABA projection disrupts reward behaviors
Birnie, M. T.; Short, A. K.; de Carvalho, G. B.; Gunn, B. G.; Pham, A. L.; Itoga, C. A.; Xu, X.; Chen, L. Y.; Mahler, S. V.; Chen, Y.; Baram, T. Z.
10.1101/2022.07.01.498504 — neuroscience — Posted on 2022-07-03
3709 Mechanical vibration modulates regional cerebral blood flow and biomechanical co-variance network in a frequency-dependent manner
Kong, L.; Qiu, S.; Chen, Y.; He, Z.; Huang, P.; He, Q.; Zhang, R.; Feng, X.-Q.; Deng, L.; Li, Y.; Yan, F.; Yang, G.; Feng, Y.
10.1101/2022.06.28.498036 — neuroscience — Posted on 2022-07-03
3711 Gene Regulatory Network Reconfiguration in Direct Lineage Reprogramming
Kamimoto, K.; Adil, M. T.; Jindal, K.; Hoffmann, C. M.; Kong, W.; Yang, X.; Morris, S. A.
10.1101/2022.07.01.497374 — genomics — Posted on 2022-07-03
3715 Morphological and genetic diversity of maize landraces along an altitudinal gradient in the Southern Andes
Rivas, J. G.; Gutierrez, A. V.; Defacio, R. A.; Schimpf, J.; Vicario, A. L.; Hopp, H. E.; Paniego, N. B.; Lia, V. V.
10.1101/2022.07.01.498464 — evolutionary biology — Posted on 2022-07-02
3719 Mechanical vibration modulates regional cerebral blood flow and biomechanical co-variance network in a frequency-dependent manner
Kong, L.; Qiu, S.; Chen, Y.; He, Z.; Huang, P.; He, Q.; Zhang, R.; Feng, X.-Q.; Deng, L.; Li, Y.; Yan, F.; Yang, G.; Feng, Y.
10.1101/2022.06.28.498036 — neuroscience — Posted on 2022-07-02
3720 USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient and CCCP-stressed human iPSC-derived neurons
Okarmus, J.; Bach Agergaard, J.; Stummann, T. C.; Haukedal, H.; Ambjorn, M.; Freude, K. K.; Fog, K.; Meyer, M.
10.1101/2022.06.29.498100 — neuroscience — Posted on 2022-07-02
3722 Convergent gene expression highlights shared vocal motor microcircuitry in songbirds and humans
Gedman, G. L.; Biegler, M. T.; Haase, B.; Wirthlin, M.; Fedrigo, O.; Pfenning, A. R.; Jarvis, E. D.
10.1101/2022.07.01.498177 — neuroscience — Posted on 2022-07-02
3726 Complex functional phenotypes of NMDA receptor disease variants
Iacobucci, G. J.; Liu, B.; Wen, H.; Sincox, B.; Zheng, W.; Popescu, G. K.
10.1101/2022.07.01.498520 — biophysics — Posted on 2022-07-02
3730 Membrane stretching activates calcium-permeability of a putative channel Pkd2 during fission yeast cytokinesis
Poddar, A.; Hsu, Y.-Y.; Zhang, F.; Shamma, A. S.; Kreais, Z.; Muller, C. T.; Malla, M.; Ray, A.; Liu, A.; Chen, Q.
10.1101/2022.05.16.492180 — cell biology — Posted on 2022-07-02
3732 Loosenin-like proteins from Phanerochaete carnosa impact both cellulose and chitin fiber networks
Monschein, M.; Ioannou, E.; Amin, L. A. A.; Varis, J. J.; Wagner, E. R.; Mikkonen, K. S.; Cosgrove, D. J.; Master, E. R.
10.1101/2022.07.01.498415 — microbiology — Posted on 2022-07-02
3733 Single cell carbon and nitrogen incorporation and remineralization profiles are uncoupled from phylogenetic groupings of diatom-associated bacteria
Mayali, X.; Samo, T. J.; Kimbrel, J.; Stuart, R.; Morris, M. M.; Rolison, K.; Ramon, C.; Kim, Y.-M.; Munoz-Munoz, N.; Nicora, C. D.; Purvine, S. O.; Lipton, M.; Weber, P. K.
10.1101/2022.07.01.498368 — microbiology — Posted on 2022-07-02
3735 Polyunsaturated fatty acids alter the formation of lipid droplets and eicosanoid production in Leishmania promatigotes
Andrade, Y. M. F. d. S.; Castro, M. V. d.; Tavares, V. d. S.; Souza, R. d. S. O.; Faccioli, L. H.; Lima, J. B.; Sorgi, C. A.; Borges, V. M.; Araujo-Santos, T.
10.1101/2022.07.01.498279 — microbiology — Posted on 2022-07-02
3736 Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates
Zhang, Y.-N.; Paynter, J.; Antanasijevic, A.; Allen, J. D.; Lee, Y.-Z.; Eldad, M.; Copps, J.; Newby, M.; He, L.; Wilson, I. A.; Crispin, M.; Ward, A.; Zhu, J.
10.1101/2022.07.01.498503 — microbiology — Posted on 2022-07-02
3738 Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis
Fabre, T.; Barron, A. M. S.; Christensen, S. M.; Asano, S.; Wadsworth, M. H.; Chen, X.; Wang, J.; McMahon, J.; Schlerman, F. J.; White, A.; Hart, K. M.; Kravarik, K.; Fisher, A. J.; Borthwick, L. A.; Henderson, N. C.; Wynn, T. A.; Dower, K.
10.1101/2022.07.01.498017 — immunology — Posted on 2022-07-02
3739 EasyGuide plasmids support in vivo assembly of gRNAs for CRISPR/Cas9 applications in Saccharomyces cerevisiae
Jacobus, A. P.; Barreto, J. A.; de Bem, L. S.; Menegon, Y. A.; Fier, I.; Bueno, J. G. R.; dos Santos, L. V.; Gross, J.
10.1101/2022.07.01.498453 — synthetic biology — Posted on 2022-07-02
3741 Zika virus NS4A hijacks host ANKLE2 to promote viral replication
Fishburn, A. T.; Kenaston, M. W.; Lopez, N. J.; Hoang, V.; Shiu, T. N.; Haggard Arce, S. T.; Khan, S. S.; Shah, P. S.
10.1101/2022.03.15.484510 — molecular biology — Posted on 2022-07-02
3742 Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection
Jalbert, E.; Liu, C.; Mave, V.; Lang, N.; Kagal, A.; Valvi, C.; Paradkar, M.; Gupte, N.; Lokhande, R.; Bharadwaj, R.; Kulkarni, V.; Gupta, A.; Weinberg, A.
10.1101/2022.06.13.495865 — immunology — Posted on 2022-07-02
3744 Heroin self-administration and extinction increases prelimbic cortical astroglia-synapse proximity and alters dendritic spine morphometrics that are reversed by N-acetylcysteine
Siemsen, B. M.; Denton, A. R.; Hooker, K. N.; Carpenter, E. A.; Prescott, M. E.; Brock, A. G.; Leath, M. N.; McFaddin, J. A.; McGinty, J. F.; Scofield, M. D.
10.1101/2020.05.21.108530 — neuroscience — Posted on 2022-07-02
3746 Architecture of the chikungunya virus replication organelle
Laurent, T.; Kumar, P.; Liese, S.; Zare, F.; Jonasson, M.; Carlson, A.; Carlson, L.-A.
10.1101/2022.04.05.487153 — biophysics — Posted on 2022-07-02
3747 Photovoltaic Implant Simulator Reveals the Resolution Limits in Subretinal Prosthesis
Chen, Z. C.; Wang, B.; Goldstein, A. K.; Butt, E.; Mathieson, K.; Palanker, D.
10.1101/2022.06.30.498210 — bioengineering — Posted on 2022-07-02
3748 APC couples neuronal mRNAs to multiple kinesins, EB1 and shrinking microtubule ends for bidirectional mRNA motility
Baumann, S. J.; Grawenhoff, J.; Rodrigues, E. C.; Speroni, S.; Gili, M.; Komissarov, A.; Maurer, S. P.
10.1101/2022.07.01.498380 — biochemistry — Posted on 2022-07-02
3756 The human placenta exhibits a unique transcriptomic void
Gong, S.; Gaccioli, F.; Aye, I. L. M. H.; Avellino, G.; Cook, E.; Lawson, A. R. J.; Harvey, L. M. R.; Smith, G. C. S.; Charnock-Jones, S.
10.1101/2022.07.01.498408 — genomics — Posted on 2022-07-02
3757 Cell type- and state- resolved immune transcriptomic profiling identifies glucocorticoid-responsive molecular defects in multiple sclerosis T cells
Roostaei, T.; Sabrin, A.; Kivisakk, P.; McCabe, C.; Nejad, P.; Felsky, D.; Touil, H.; Vlachos, I.; Hui, D.; Fransson, J.; Patsopoulos, N. A.; Kuchroo, V. K.; Zujovic, V.; Weiner, H. L.; Klein, H.-U.; De Jager, P. L.
10.1101/2022.06.29.498195 — genomics — Posted on 2022-07-02
3758 Riboflavin Depletion Promotes Longevity and Metabolic Hormesis in Caenorhabditis elegans
Yerevanian, A.; Murphy, L.; Emans, S.; Zhou, Y.; Ahsan, F.; Baker, D.; Li, S.; Adedoja, A.; Cedillo, L.; Gnanatheepam, E.; Dao, K.; Jain, M.; Georgakoudi, I.; Soukas, A. A.
10.1101/2022.06.30.498343 — genetics — Posted on 2022-07-02
3759 Insight into diatoms diversity at two European coastal sites (LTER-MC in the Mediterranean Sea and SOMLIT-Astan in the Western English Channel) using a DNA metabarcoding approach
Caracciolo, M.; Berney, C.; Alric, B.; Piredda, R.; Zingone, A.; Sarno, D.; Percopo, I.; Romac, S.; Le Gall, F.; Rigaut-Jalabert, F.; Baudoux, A.-C.; Simon, N.; Henry, N.
10.1101/2022.07.01.498404 — ecology — Posted on 2022-07-02
3760 HT-SIP: A semi-automated Stable Isotope Probing pipeline identifies interactions in the hyphosphere of arbuscular mycorrhizal fungi
Nuccio, E. E.; Blazewicz, S. J.; Lafler, M.; Campbell, A. N.; Kakouridis, A.; Kimbrel, J. A.; Wollard, J.; Vyshenska, D.; Riley, R.; Tomatsu, A.; Hestrin, R.; Malmstrom, R.; Firestone, M. K.; Pett-Ridge, J.
10.1101/2022.07.01.498377 — microbiology — Posted on 2022-07-02
3762 Fishing Cat Cell Biobanking for Conservation
Sukparangsi, W.; Thongphakdee, A.; Karoon, S.; Suban Na Ayuttaya, N.; Hengkhunthod, I.; Parkongkeaw, R.; Bootsri, R.; Sikaeo, W.
10.1101/2022.07.01.498384 — zoology — Posted on 2022-07-02
3764 CanSeer: A Method for Development and Clinical Translation of Personalized Cancer Therapeutics
Butt, R. N.; Amina, B.; Sultan, M. U.; Tanveer, Z. B.; Hussain, R.; Akbar, R.; Khan, S.; Gondal, M. N.; Khalid, M. F.; Faisal, A.; Shoaib, M.; Chaudhary, S. U.
10.1101/2022.06.29.498138 — systems biology — Posted on 2022-07-02
3765 A modular dCas9-based recruitment platform for combinatorial epigenome editing
Swain, T.; Pflueger, C.; Freytag, S.; Poppe, D.; Pflueger, J.; Nguyen, T. V.; Li, J. K.; Lister, R.
10.1101/2022.07.01.498378 — synthetic biology — Posted on 2022-07-02
3767 Early phyllosphere microbial associations impact plant reproductive success
Mehlferber, E. C.; McCue, K. F.; Debray, R.; Kaulbach, G.; Ferrel, J. E. C.; Khanna, R.; Koskella, B.
10.1101/2022.06.30.498294 — plant biology — Posted on 2022-07-02
3772 Paracrine signaling by pancreatic delta cells determines the glycemic set point in mice
Huang, J. L.; Lee, S.; Pourhosseinzadeh, M. S.; Krämer, N.; Guillen, J. V.; Cinque, N. H.; Aniceto, P. A.; Koike, S.; Huising, M. O.
10.1101/2022.06.29.496132 — physiology — Posted on 2022-07-02
3773 Sclerostin influences exercise-induced adaptations in body composition and white adipose tissue morphology in male mice
Kurgan, N.; Stoikos, J.; Baranowski, B. J.; Yumol, J.; Dhaliwal, R.; Sweezey-Munroe, J. B.; Fajardo, V.; Gittings, W.; MacPherson, R. E.; Klentrou, P.
10.1101/2022.06.29.498123 — physiology — Posted on 2022-07-02
3775 Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents
Faber, E. B.; Tang, J.; Roberts, E.; Ganeshkumar, S.; Sun, L.; Wang, N.; Rasmussen, D.; Majumbar, A.; John, K.; Yang, A.; Khalid, H.; Hawkinson, J. E.; Levinson, N. M.; Schonbrunn, E.; Chennathukuzhi, V.; Harki, D. A.; Georg, G. I.
10.1101/2022.06.30.497818 — pharmacology and toxicology — Posted on 2022-07-02
3777 Intestinal Epithelial Heat Shock Protein 25/27 integrates host and microbial drivers of mucosal restitution following inflammatory injury
Cham, C. M.; Messer, J. S.; Lake, J. M.; Zhu, X.; Tao, Y.; He, L.; Weber, C. R.; Lin, F.; Dai, Z.; Tong, J.; Temelkova, S.; Rubin, D. T.; Liu, C.; Chang, E. B.
10.1101/2022.06.30.498349 — pathology — Posted on 2022-07-02
3782 Slice'N'Dice: Maximising the value of predicted models for structural biologists
Simpkin, A. J.; Elliott, L. G.; Stevenson, K.; Krissinel, E.; Rigden, D.; Keegan, R. M.
10.1101/2022.06.30.497974 — bioinformatics — Posted on 2022-07-02
3786 Pixel size limit of the PRIMA implants: from humans to rodents and back
Wang, B.-Y.; Chen, Z. C.; Bhuckory, M.; Kochnev Goldstein, A.; Palanker, D.
10.1101/2022.06.29.498181 — bioengineering — Posted on 2022-07-02
3787 A short-term decellularisation technique for porcine carotid arteries that conveys a structural stimulus to cells
Fitzpatrick, E.; Gaul, R.; Smekens, C.; Mathieu, P. S.; Meehan, B.; Tornifoglio, B.; Cahill, P. A.; Lally, C.
10.1101/2022.06.28.497956 — bioengineering — Posted on 2022-07-02
3788 Photovoltaic Implant Simulator Reveals the Resolution Limits in Subretinal Prosthesis
Chen, Z. C.; Wang, B.; Goldstein, A. K.; Butt, E.; Mathieson, K.; Palanker, D.
10.1101/2022.06.30.498210 — bioengineering — Posted on 2022-07-02
3793 Context-dependent transcriptional remodeling of TADs during differentiation
Chahar, S.; Ben Zouari, Y.; Salari, H.; Molitor, A. M.; Kobi, D.; Maroquenne, M.; Erb, C.; Karasu, N.; Jost, D.; Sexton, T.
10.1101/2022.07.01.498405 — genomics — Posted on 2022-07-02
3795 Genetic requirements for repair of lesions caused by single genomic ribonucleotides in S phase
Schindler, N.; Tonn, M.; Kellner, V.; Fung, J. J.; Lockhart, A.; Vydzhak, O.; Juretschke, T.; Moeckel, S.; Beli, P.; Khmelinskii, A.; Luke, B.
10.1101/2022.06.30.498227 — genetics — Posted on 2022-07-02
3798 Nitrogen competition is the general mechanism underlying cnidarian-Symbiodiniaceae symbioses
Cui, G.; Mi, J.; Moret, A.; Zhong, H.; Hung, S.-H.; Al-Babili, S.; Aranda, M.
10.1101/2022.06.30.498212 — ecology — Posted on 2022-07-02
3799 In-depth study of tomato and weed viromes reveals undiscovered plant virus diversity in an agroecosystem
Rivarez, M. P. S.; Pecman, A.; Bacnik, K.; Maksimovic Carvalho Ferreira, O.; Vucurovic, A.; Seljak, G.; Mehle, N.; Gutierrez-Aguirre, I.; Ravnikar, M.; Kutnjak, D.
10.1101/2022.06.30.498278 — ecology — Posted on 2022-07-02
3800 RevGel-seq: instrument-free single-cell RNA sequencing using a reversible hydrogel for cell-specific barcoding
Komatsu, J.; Cico, A.; Poncin, R.; LeBohec, M.; Morf, J.; Lipin, S.; Grandorge, A.; Eckert, H.; Saffarian, A.; Cathaly, L.; Guerin, F.; Majello, S.; Ulveling, D.; Vayaboury, A.; Fernandez, N.; Dimitrova, D.; Bussell, X.; Fourne, Y.; Chaumat, P.; Andre, B.; Baldivia, E.; Godet, U.; Guinin, M.; Moretto, V.; Ismail, J.; Caille, O.; Roblot, N.; Beaupere, C.; Liboz, A.; Guillemain, G.; Blondeau, B.; Walrafen, P.; Edelstein, S. J.
10.1101/2022.07.01.498266 — cell biology — Posted on 2022-07-02
3801 An optimised method for bacterial nucleic acid extraction from positive blood culture broths for whole genome sequencing, resistance phenotype prediction and downstream molecular applications
Bauer, M.; Peri, A. M.; Luftinger, L.; Beisken, S.; Bergh, H.; Forde, B. M.; Buckley, C.; Cuddihy, T.; Tan, P.; Paterson, D.; Whiley, D. M.; Harris, P. N. A.
10.1101/2022.06.30.497578 — microbiology — Posted on 2022-07-02
3803 Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in vivo in CNS
Conroy, F.; Miller, R.; Alterman, J. F.; Hassler, M. R.; Echeverria, D.; Godinho, B. M. D. C.; Knox, E. G.; Sapp, E.; Sousa, J.; Yamada, K.; Mahmood, F.; Boudi, A.; Kegel-Gleason, K.; DiFiglia, M.; Aronin, N.; Khvorova, A.; Pfister, E. L.
10.1101/2022.06.29.498088 — neuroscience — Posted on 2022-07-02
3805 Silencing of ApoE with Divalent siRNAs Drives Activation of Immune Clearance Pathways and Improves Amyloid Pathology in Mouse Models of Alzheimer's Disease
Ferguson, C.; Hildebrand, S.; Godinho, B. M. D. C.; Buchwald, J.; Echeverria, D.; Coles, A.; Grigorenko, A.; Vanjielli, L.; Sousa, J.; McHugh, N.; Hassler, M.; Santarelli, F.; Heneka, M. T.; Rogaev, E.; Khvorova, A.
10.1101/2022.06.28.498012 — neuroscience — Posted on 2022-07-02
3807 A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes
Wang, Y.; Wang, D.; Lin, J.; Lyu, Z.; Chen, P.; Sun, T.; Xue, C.; Mojtabavi, M.; Vedadghavami, A.; Zhang, Z.; Wang, R.; Zhang, L.; Park, C.; Heo, G. S.; Liu, Y.; Dong, S.; Zhang, K.
10.1101/2022.06.30.498214 — pharmacology and toxicology — Posted on 2022-07-02
3809 CircRNA-regulated immune response of Asian honey bee workers to microsporidian infection
Zhu, Z.; Wang, J.; Fan, X.; Long, Q.; Chen, H.; Ye, Y.; Zhang, K.; Ren, Z.; Zhang, Y.; Niu, Q.; Chen, D.; Guo, R.
10.1101/2022.06.30.498258 — pathology — Posted on 2022-07-02
3813 Tyrosine kinase inhibitor independent gene expression signature in CML offers new targets for LSPC eradication therapy
Gomez-Castaneda, E.; Rogers, S.; Munje, C.; Bittencourt-Silvestre, J.; Copland, M.; Vetrie, D.; Hopcroft, L.; Jorgensen, H.; Holyoake, T.
10.1101/2022.06.30.498287 — cancer biology — Posted on 2022-07-02
3814 The Fatty Acid Binding Protein Family Represents a Novel Target in Multiple Myeloma
Farrell, M.; Fairfield, H.; Karam, M.; D'Amico, A.; Murphy, C. S.; Falank, C.; Pistofidi, R. S.; Cao, A.; Marinac, C. R.; Dragon, J. A.; McGuinness, L.; Gartner, C. G.; Iorio, R. D.; Jachimowicz, E.; DeMambro, V.; Vary, C.; Reagan, M. R.
10.1101/2022.07.01.498411 — cancer biology — Posted on 2022-07-02
3816 Visualization of a Limonene Synthesis Metabolon inside Living Bacteria by Hyperspectral SRS Microscopy
Zhang, J.; Shin, J.; Tague, N.; Lin, H.; Zhang, M.; Ge, X.; Wong, W.; Dunlop, M.; Cheng, J.-X.
10.1101/2022.06.30.498009 — biophysics — Posted on 2022-07-02
3817 Long-range communication between transmembrane- and nucleotide-binding domains does not depend on drug binding to mutant P-glycoprotein
Bonito, C. A.; Ferreira, R. J.; Ferreira, M.-J. U.; Gillet, J.-P.; Cordeiro, M. N. D. S.; dos Santos, D. J. V. A.
10.1101/2022.06.30.498271 — biophysics — Posted on 2022-07-02
3826 Healthy and diseased placenta barrier on-a-chip models suitable for high-throughput studies
Rabussier, G.; Bünter, I.; Bouwhuis, J.; Soragni, C.; Ng, C. P.; Dormansky, K.; de Windt, L. J.; Vulto, P.; Murdoch, C. E.; Bircsak, K. M.; Lanz, H. L.
10.1101/2022.06.30.498115 — bioengineering — Posted on 2022-07-02
3827 Acetaminophen production in the edible, filamentous cyanobacterium Arthrospira platensis
Hilzinger, J. M.; Freidline, S.; Sivanandan, D.; Cheng, Y.-F.; Yamazaki, S.; Clark, D. S.; Skerker, J. M.; Arkin, A. P.
10.1101/2022.06.30.498297 — bioengineering — Posted on 2022-07-02
3832 Discovery of two novel Torque Teno viruses in Callithrix penicillata provides insights on Anelloviridae diversification dynamics
Cosentino, M. A. C.; D'arc, M.; Moreira, F. R. R.; Cavalcante, L. T. F.; Mouta, R.; Coimbra, A.; Schiffler, F. B.; Miranda, T. S.; Medeiros, G.; Dias, C. A.; Souza, A. R.; Tavares, M. C. H.; TANURI, A.; Soares, M. A.; Santos, A. F. A.
10.1101/2022.06.30.498111 — genetics — Posted on 2022-07-02
3835 Genome duplication and transposon mediated gene alteration shapes the pathogenicity of Rhizoctonia solani AG1-IA
Francis, A.; Ghosh, S.; Tyagi, K.; Prakasam, V.; Rani, M.; Singh, N.; Pradhan, A.; Sundaram, R. M.; Priyanka, C.; Laha, G. S.; Kannan, C.; Prasad, M. S.; Chattopadhyay, D.; Jha, G.
10.1101/2022.07.01.498367 — evolutionary biology — Posted on 2022-07-02
3837 Life history strategies and niches of soil bacteria emerge from interacting thermodynamic, biophysical, and metabolic traits
Marschmann, G. L.; Tang, J.; Zhalnina, K.; Karaoz, U.; Cho, H.; Le, B.; Pett-Ridge, J.; Brodie, E. L.
10.1101/2022.06.29.498137 — ecology — Posted on 2022-07-02
3841 Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia
Caxaria, S.; Bharde, S.; Fuller, A. M.; Evans, R.; Thomas, B.; Celik, P.; Dell'Accio, F.; Yona, S.; Gilroy, D.; Voisin, M. B.; Wood, J. N.; Sikandar, S.
10.1101/2022.06.29.498149 — neuroscience — Posted on 2022-07-02
3843 Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming.
Keine, C.; Al-Yaari, M.; Radulovic, T.; Thomas, C. I.; Ramos, P. V.; Guerrero-Given, D.; Kamasawa, N.; Young, S. M.
10.1101/2022.06.29.497712 — neuroscience — Posted on 2022-07-02
3845 Genetically corrected iPSC-derived Neural Stem Cell Grafts deliver NAGLU-IGFII fusion protein to affect CNS disease in Sanfilippo B Mice
Pearse, Y.; Clarke, D.; Kan, S.-h.; Le, S. Q.; Sanghez, V.; Luzzi, A.; Pham, I.; Nih, L. R.; Cooper, J. D.; Dickson, P.; Iacovino, M.
10.1101/2022.06.30.498131 — neuroscience — Posted on 2022-07-02
3849 A conserved role of Hippo signaling in initiation of the first lineage specification event across mammals
Gerri, C.; McCarthy, A.; Scott, G. M.; Regin, M.; Brumm, S.; Simon, C. S.; Lee, J.; Montesinos, C.; Hassitt, C.; Hockenhull, S.; Hampshire, D.; Elder, K.; Snell, P.; Christie, L.; Fouladi-Nashta, A. A.; Van de Velde, H.; Niakan, K.
10.1101/2022.07.01.498418 — developmental biology — Posted on 2022-07-02
3850 The extracellular matrix protein fibronectin modulates metanephric kidney development
Skoczynski, K.; Kraus, A.; Buettner-Herold, M.; Amann, K.; Schiffer, M.; Hermann, K.; Herrnberger, L.; Tamm, E. R.; Buchholz, B.
10.1101/2022.07.01.497442 — developmental biology — Posted on 2022-07-02
3851 Regulation of oxidative phosphorylation by Nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice
Venit, T.; Sapkota, O.; Abdrabou, W. S.; Loganathan, P.; Pasricha, R.; Mahmood, S. R.; El Said, N.; Thomas, S.; Idaghdour, Y.; Magzoub, M.; Percipalle, P.
10.1101/2022.06.30.498328 — cell biology — Posted on 2022-07-02
3857 Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma
Datta, M.; Chatterjee, S.; Perez, E. M.; Gritsch, S.; Roberge, S.; Duquette, M.; Chen, I. X.; Naxerova, K.; Kumar, A. S.; Ghosh, M.; Emblem, K. E.; Ng, M. R.; Ho, W. W.; Kumar, P.; Krishnan, S.; Dong, X.; Speranza, M. C.; Neagu, M. R.; Reardon, D. A.; Sharpe, A. H.; Freeman, G. J.; Suva, M. L.; Xu, L.; Jain, R. K.
10.1101/2022.06.28.497997 — cancer biology — Posted on 2022-07-02
3858 Enabling spectrally resolved single-molecule localization microscopy at high emitter densities
Martens, K. J. A.; Gobes, M.; Archontakis, E.; Brillas, R. R.; Zijlstra, N.; Albertazzi, L.; Hohlbein, J.
10.1101/2022.06.29.498127 — biophysics — Posted on 2022-07-02
3863 Molecular characteristics of phages located in Carbapenemase-Producing Escherichia coli clinical isolates: New Phage-Like Plasmids
Diaz, M. L.; Bleriot, I.; Pacios, O.; Fernandez-Garcia, L.; Blasco, L.; Ambroa, A.; Ortiz-Cartagena, C.; Woodford, N.; Ellington, M. J.; Tomas, M.
10.1101/2022.06.29.498070 — bioinformatics — Posted on 2022-07-02
3867 Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer
Choi, S.; Whitman, M. A.; Shimpi, A. A.; Chiou, A.; Druso, J. E.; Verma, A.; Lux, S. C.; Cheng, Z.; Paszek, M.; Elemento, O.; Estroff, L. A.; Fischbach, C.
10.1101/2022.06.29.498001 — bioengineering — Posted on 2022-07-02
3869 Assessing jugular venous compliance with optical hemodynamic imaging by modulating intrathoracic pressure
Amelard, R.; Flannigan, N.; Patterson, C. A.; Heigold, H.; Hughson, R. L.; Robertson, A. D.
10.1101/2022.06.28.497963 — bioengineering — Posted on 2022-07-02
3871 A novel approach to quantifying inter-individual distance in insects
Corthals, K.; Hueper, L.; Neumann, S.; Heinrich, R.; Gras, H.; Geurten, B. R. H.
10.1101/2022.06.28.497925 — animal behavior and cognition — Posted on 2022-07-02
3872 Was fishing village of Lepenski Vir built by Europe's first farmers?
Brami, M. N.; Winkelbach, L.; Schulz, I.; Schreiber, M.; Bloecher, J.; Diekmann, Y.; Burger, J.
10.1101/2022.06.28.498048 — genomics — Posted on 2022-07-02
3874 Escape From Oncogene-Induced Senescence is Controlled by POU2F2 and Memorized by Chromatin Scars
Martinez-Zamudio, R. I.; Stefa, A.; Nabuco, J. A.; Vasilopoulos, T.; Simpson, M.; Dore, G.; Roux, P.-F.; Galan, M. A.; Chokshi, R. J.; Bischof, O.; Herbig, U.
10.1101/2022.06.29.497942 — genomics — Posted on 2022-07-02
3875 The genomic basis of evolutionary novelties in a leafhopper
Li, Z.; Li, Y.; Xue, A. Z.; Dang, V.; Holmes, V. R.; Johnston, J. S.; Barrick, J. E.; Moran, N. A.
10.1101/2022.06.28.497946 — genomics — Posted on 2022-07-02
3876 Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant PLS3 mutation
Hu, J.; Zhou, B.; Lin, X.; Zhang, Q.; Guan, F.; Lei, S.; Liu, J.; Wang, O.; Jiang, Y.; Xia, W.-b.; Xing, X.; Li, M.
10.1101/2022.06.29.498081 — genetics — Posted on 2022-07-02
3881 Evolutionary survival strategies of the female giant panda: optimizing energy resources and expenditure prior to pregnancy by postponing corpus luteum reactivation
Wauters, J. R. M.; Wilson, K. S.; Bouts, T.; Vancsok, C.; Mulot, B.; Leclerc, A.; Haapakoski, M.; Kok, J.; Kuehne, R.; Ochs, A.; McNeilly, A. S.; Rae, M.; Andrew, R.; Duncan, W. C.; Girling, S. J.; Zhou, Q.; Li, R.; Zhou, Y.; Cai, K.; Liu, Y.; Hou, R.; Valentine, I.; Hildebrandt, T. B.; Li, D.; Vanhaecke, L.
10.1101/2022.06.28.497916 — evolutionary biology — Posted on 2022-07-02
3883 Global environmental drivers of local abundance-mass scaling in soil animal communities
Antunes, A. C.; Gauzens, B.; Brose, U.; Potapov, A.; Jochum, M.; Santini, L.; Eisenhauer, N.; Ferlian, O.; Cesarz, S.; Scheu, S.; Hirt, M. R.
10.1101/2022.06.29.498075 — ecology — Posted on 2022-07-02
3885 Sensitivity of bipartite network analyses to incomplete sampling and taxonomic uncertainty
Llopis-Belenguer, C.; Balbuena, J. A.; Blasco-Costa, I.; Karvonen, A.; Sarabeev, V.; Jokela, J.
10.1101/2022.06.28.497912 — ecology — Posted on 2022-07-02
3888 The impact of ants and vertebrate predators on arthropods and plants: a meta-analysis
Sam, K.; Houska Tahadlova, M.; Mrazova, A.; Freiberga, I.; Toszogyova, A.; Sreekar, R.
10.1101/2022.06.29.498005 — ecology — Posted on 2022-07-02
3893 Host-enemy interactions provide limited biotic resistance for a range-expanding species via reduced apparent competition
Prior, K. M.; Jones, D. G.; Meadley-Dunphy, S. A.; Lee, S.; Milks, A. K.; Daughton, S.; Forbes, A. A.; Powell, T. H.
10.1101/2022.06.28.498037 — ecology — Posted on 2022-07-02
3895 Modelling Instantaneous Firing Rate of DBS Target Neuronal Ensembles in Basal Ganglia and Thalamus
Tian, Y.; Murphy, M. J. H.; Steiner, L. A.; Kalia, S.; Hodaie, M.; Lozano, A.; Hutchison, W. D.; Popovic, M.; Milosevic, L.; Lankarany, M.
10.1101/2022.06.28.497834 — neuroscience — Posted on 2022-07-02
3897 Heterotopic ossification in intact rat Achilles tendons is characterized by unique mineralized collagen fiber structures
Pierantoni, M.; Hammerman, M.; Andersson, L.; Barreto, I. S.; Novak, V.; Isaksson, H.; Eliasson, P.
10.1101/2022.06.28.497706 — physiology — Posted on 2022-07-02
3898 High-throughput platform for depolarization-induced Ca2+ release for skeletal muscle disease mutation validation and drug discovery
Murayama, T.; Kurebayashi, N.; Numaga-Tomita, T.; Kobayashi, T.; Okazaki, S.; Yamashiro, K.; Nakada, T.; Mori, S.; Ishida, R.; Kagechika, H.; Yamada, M.; Sakurai, T.
10.1101/2022.06.29.498090 — physiology — Posted on 2022-07-02
3902 Graphene Biointerface for Cardiac Arrhythmia Diagnosis and Treatment
Lin, Z.; Kireev, D.; Liu, N.; Gupta, S.; LaPaino, J.; Obaid, S.; Chen, Z.; Akinwande, D.; Efimov, I. R.
10.1101/2022.06.28.497825 — bioengineering — Posted on 2022-07-02
3909 Microwell-based flow culture reduces hypoxia-induced phenotype and restores drug response in prostate cancer spheroids
Payne, M.; Ho, S.; Hashimoto, T.; Imboden, S.; Lee, B.; Rupert, M.; Cai, N.; Goldstein, A.; Lin, N.
10.1101/2022.06.28.498007 — bioengineering — Posted on 2022-07-02
3910 Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition
Li, Y.; Balakrishnan, V. K.; Rowse, M.; Wu, C.-G.; Bravos, A. P.; Yadav, V. K.; Ivarsson, Y.; Strack, S.; Novikova, I. V.; Xing, Y.
10.1101/2022.07.01.498399 — biochemistry — Posted on 2022-07-01
3912 Anellovirus Structure Reveals a Mechanism for Immune Evasion
Swanson, K. A.; Liou, S.-H.; Delagrave, S.; Hajiar, R.; Chang, Y.; Yozwiak, N.; Ong, T.; Rodgers, H.; Cohen, N.; Zhang, Y.; Mukund Acharekar, N.; Islam, S.; Zaheb, L.; Arze, C.; Swaminathan, H.; Pitts, J.
10.1101/2022.07.01.498313 — biochemistry — Posted on 2022-07-02
3915 Intracellular carbon storage by microorganisms is an overlooked pathway of biomass growth
Mason-Jones, K.; Breidenbach, A.; Dyckmans, J.; Banfield, C. C.; Dippold, M. A.
10.1101/2022.06.28.497677 — ecology — Posted on 2022-07-01
3918 VSTM1-v2 does not drive human Th17 cell differentiation
von Richthofen, H. J.; Hafkamp, F. M. J.; van Haperen, A.; de Jong, E. C.; Meyaard, L.
10.1101/2022.06.28.497941 — immunology — Posted on 2022-07-01
3919 IL-15 superagonist N-803 enhances IFNγ production and alters the trafficking of MAIT cells in SIV+ macaques
Ellis-Connell, A.; Balgeman, A. J.; Kannal, N. M.; Hansen Chaimson, K.; Batchenkova, A.; Safrit, J. T.; O'Connor, S. L.
10.1101/2022.06.28.498052 — immunology — Posted on 2022-07-01
3920 A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma
Alchahin, A. M.; Mei, S.; Tsea, I.; Hirz, T.; Kfoury, Y.; Dahl, D.; Wu, C.-L.; Subtelny, A. O.; Wu, S.; Scadden, D. T.; Shin, J. H.; Saylor, P. J.; Sykes, D. B.; Kharchenko, P. V.; Baryawno, N.
10.1101/2022.06.28.497333 — cancer biology — Posted on 2022-07-01
3922 Non-invasive quantification of contractile dynamics in cardiac cells, spheroids and organs-on-a-chip using high frequency ultrasound
Strohm, E. M.; Callaghan, N. I.; Latifi, N.; Rafatian, N.; Funakoshi, S.; Fernandes, I.; Radisic, M.; Keller, G.; Kolios, M.; Simmons, C. A.
10.1101/2022.06.28.497094 — bioengineering — Posted on 2022-07-01
3924 APC couples neuronal mRNAs to multiple kinesins and EB1 for bidirectional mRNA movements along microtubules
Baumann, S. J.; Grawenhoff, J.; Rodrigues, E. C.; Speroni, S.; Gili, M.; Komissarov, A.; Maurer, S. P.
10.1101/2022.07.01.498380 — biochemistry — Posted on 2022-07-01
3927 A Chromosome-level Assembly of the Japanese Eel Genome, Insights into Gene Duplication and Chromosomal Reorganization
WANG, H.; WAN, H. T.; WU, B.; JIAN, J.; NG, A. H.; CHUNG, C. Y.-L.; CHOW, E. Y.-C.; ZHANG, J.; WONG, A. O.; LAI, K. P.; CHAN, T. F.; Zhang, E. L.; WONG, C. K.-C.
10.1101/2022.06.28.497880 — genomics — Posted on 2022-07-01
3930 The SCN1A Philadelphia variant - a gain-of-function mutation causing an early-onset epileptic encephalopathy
Clatot, J.; Parthasarathy, S.; Cohen, S. R.; McKee, J. L.; Massey, S. L.; Somarowthu, A.; Goldberg, E. M.; Helbig, I.
10.1101/2022.06.29.498154 — genetics — Posted on 2022-07-01
3932 SiPLATZ12 transcript factor regulates multiple yield traits and salt tolerance in foxtail millet (Setaria italica)
Wu, C.; Xiao, S.; Wan, Y.; Zhang, L.; Tang, S.; Sui, Y.; Bai, Y.; Wang, Y.; Liu, M.; Fan, J.; Zhang, S.; Huang, J.; Yang, G.; Yan, K.; Diao, X.; Zheng, C.
10.1101/2022.07.01.498439 — molecular biology — Posted on 2022-07-01
3934 Microbiome response in an urban river system is dominated by seasonality over wastewater treatment upgrades
Kodera, S. M.; Sharma, A.; Martino, C.; Dsouza, M.; Grippo, M.; Lutz, H.; Knight, R.; Gilbert, J. A.; Negri, M. C.; Allard, S. M.
10.1101/2022.06.30.498375 — microbiology — Posted on 2022-07-01
3936 GLT8D1 mutations cause amyotrophic lateral sclerosis via disruption of neurotrophin signalling within membrane lipid rafts
Moll, T.; Graves, E.; Urbanek, A.; Soni, N.; Ranganathan, R.; Higginbottom, A.; Wang, S.; Head, B.; Cooper-Knock, J.; Shaw, P. J.
10.1101/2022.06.28.497990 — neuroscience — Posted on 2022-07-01
3937 CRISPRi-based circuits for genetic computation in plants
Khan, M. A.; Herring, G.; Oliva, M.; Fourie, E.; Zhu, J. Y.; Johnston, B.; Pflüger, J.; Swain, T.; Pflüger, C.; Lloyd, J.; Secco, D.; Small, I.; Kidd, B.; Lister, R.
10.1101/2022.07.01.498372 — synthetic biology — Posted on 2022-07-01
3938 Long-duration and non-invasive photoacoustic imaging of multiple anatomical structures in a live mouse using a single contrast agent
KHADRIA, A.; Paavola, C. D.; Zhang, Y.; Davis, S. P. X.; Grealish, P.; Maslov, K.; Shi, J.; Beals, J. M.; Oladipupo, S. S.; Wang, L. V.
10.1101/2022.05.17.491718 — bioengineering — Posted on 2022-07-01
3940 CITED2 Is A Conserved Regulator Of Deep Hemochorial Placentation
Kuna, M.; Dhakal, P.; Iqbal, K.; Dominguez, E. M.; Kent, L. N.; Muto, M.; Moreno-Irusta, A.; Kozai, K.; Varberg, K. M.; Okae, H.; Arima, T.; Sucov, H. M.; Soares, M. J.
10.1101/2022.06.15.496287 — developmental biology — Posted on 2022-07-01
3941 Targeting of scavenger receptors Stabilin-1 and Stabilin-2 ameliorates atherosclerosis by a plasma proteome switch mediating monocyte/macrophage suppression
Manta, C.-P.; Leibing, T.; Friedrich, M.; Nolte, H.; Adrian, M.; Schledzewski, K.; Krzistetzko, J.; Kirkamm, C.; Schmid, C. D.; Xi, Y. X.; Stojanovic, A.; Tonack, S.; De La Torre, C.; Hammad, S.; Offermanns, S.; Krueger, M.; Cerwenka, A.; Platten, M.; Goerdt, S.; Geraud, C.
10.1101/2022.07.01.497917 — molecular biology — Posted on 2022-07-01
3942 The heptaprenyl diphosphate synthase (Coq1) is the target of a lipophilic bisphosphonate that protects mice against Toxoplasma gondii infection
Sleda, M. A.; Li, Z.-H.; Behera, R.; Baierna, B.; Li, C.; Junpathong, J.; Malwal, S. R.; Kawamukai, M.; Oldfield, E.; Moreno, S. N. J.
10.1101/2022.04.04.487054 — microbiology — Posted on 2022-07-01
3944 A pals-25 gain-of-function allele triggers systemic resistance against natural pathogens of C. elegans
Gang, S. S.; Grover, M.; Reddy, K. C.; Raman, D.; Chang, Y.-T.; Ekiert, D. C.; Barkoulas, M.; Troemel, E. R.
10.1101/2022.06.28.497889 — immunology — Posted on 2022-07-01
3945 A crosstalk between hepcidin and IRE/IRP pathways controls ferroportinexpression and determines serum iron levels in mice
Charlebois, E.; Fillebeen, C.; Katsarou, A.; Rabinovich, A.; Wisniewski, K.; Venkataramani, V.; Michalke, B.; Velentza, A.; Pantopulos, K.
10.1101/2021.10.29.466457 — immunology — Posted on 2022-07-01
3946 Recognition of non-self is necessary to activate Drosophila's immune response against an insect parasite
B. Leitao, A.; Arunkumar, R.; Day, J. P.; Hanna, N.; Devi, A.; Hayes, M. P.; Jiggins, F. M.
10.1101/2022.06.28.497890 — immunology — Posted on 2022-07-01
3949 Reorganization of thalamocortical connections in congenitally blind humans
Marins, T.; Russo, M.; Rodrigues, E.; Monteiro, M.; Moll, J.; Felix, D.; Bouzas, J.; Arcanjo, H.; Vargas, C. D.; Tovar-Moll, F.
10.1101/449009 — neuroscience — Posted on 2022-07-01
3952 Design of a highly specific glutamine sensor by splitting the glutamine-binding protein
Seo, M.-H.; Lim, Y.; Jung, Y. H.; Lee, J. H.; Baek, M. S.; Jung, J. H.; Kim, H.-Y.; Lee, W.; Park, K.
10.1101/2022.06.28.497868 — bioengineering — Posted on 2022-07-01
3954 Improved two-step testing of genome-wide gene-environment interactions
Kawaguchi, E. S.; Kim, A. E.; Lewinger, J. P.; Gauderman, W. J.
10.1101/2022.06.14.496154 — genomics — Posted on 2022-07-01
3955 The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1
Corfield, E. C.; Frei, O.; Shadrin, A. A.; Rahman, Z.; Lin, A.; Athanasiu, L.; Cevdet Akdeniz, B.; Hannigan, L.; Wootton, R. E.; Austerberry, C.; Hughes, A.; Tesli, M.; Westlye, L. T.; Stefansson, H.; Stefansson, K.; Njolstad, P. R.; Magnus, P.; Davies, N. M.; Appadurai, V.; Hemani, G.; Hovig, E.; Zayats, T.; Ask, H.; Reichborn-Kjennerud, T.; Andreassen, O. A.; Havdahl, A.
10.1101/2022.06.23.496289 — genetics — Posted on 2022-07-01
3956 RNA polymerase II dynamics and mRNA stability feedback determine mRNA scaling with cell size
Swaffer, M. P.; Marinov, G. K.; Zheng, H.; Yee Tsui, C.; Jones, A. W.; Kundaje, A.; Greenleaf, W. J.; Reyes-Lamothe, R.; Skotheim, J. M.
10.1101/2021.09.20.461005 — molecular biology — Posted on 2022-07-01
3959 Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2-mutant meningiomas in mice
Szulzewsky, F.; Arora, S.; Arakaki, A.; Sievers, P.; Bonnin, D. A. A.; Paddison, P. J.; Sahm, F.; Cimino, P. J.; Gujral, T.; Holland, E. C.
10.1101/2022.05.02.490337 — cancer biology — Posted on 2022-07-01
3961 Deep embedding and alignment of protein sequences
Llinares-Lopez, F.; Berthet, Q.; Blondel, M.; Teboul, O.; Vert, J.-P.
10.1101/2021.11.15.468653 — bioinformatics — Posted on 2022-07-01
3964 Condensin DC loads and spreads from recruitment sites to create loop-anchored TADs in C. elegans
Kim, J.; Jimenez, D. S.; Ragipani, B.; Zhang, B.; Street, L. A.; Kramer, M.; Albritton, S. E.; Winterkorn, L.; Morao, A. K.; Ercan, S.
10.1101/2021.03.23.436694 — genomics — Posted on 2022-07-01
3965 Genomic evidence for ancient migration routes along South America's Atlantic coast
dos Santos, A. L. C.; Owings, A.; Sullasi, H. S. L.; Gokcumen, O.; DeGiorgio, M.; Lindo, J.
10.1101/2022.06.27.497820 — genomics — Posted on 2022-07-01
3966 Evolution of immune genes in island birds: reduction in population sizes can explain island syndrome
Barthe, M.; Doutrelant, C.; Covas, R.; Melo, M.; Illera, J. C.; Tilak, M.-K.; Colombier, C.; Leroy, T.; Loiseau, C.; Nabholz, B.
10.1101/2021.11.21.469450 — evolutionary biology — Posted on 2022-07-01
3968 Thalamo-hippocampal pathway regulates incidental memory load in mice
Torromino, G.; Loffredo, V.; Cavezza, D.; Sonsini, G.; Esposito, F.; Crevenna, A. H.; Gioffré, M.; De Risi, M.; Treves, A.; Griguoli, M.; De Leonibus, E.
10.1101/2021.08.07.453742 — neuroscience — Posted on 2022-07-01
3969 Socioeconomic Resources are Associated with Distributed Alterations of the Brain's Intrinsic Functional Architecture in Youth
Sripada, C.; Gard, A. M. S.; Angstadt, M.; Taxali, A.; Greathouse, T.; McCurry, K.; Hyde, L. W.; Weigard, A.; Walczyk, P.; Heitzeg, M.
10.1101/2022.06.07.495160 — neuroscience — Posted on 2022-07-01
3970 TP63-TRIM29 axis regulate enhancer methylation and chromosomal instability in prostate cancer
Sultanov, R. I.; Mulyukina, A.; Zubkova, O.; Fedoseeva, A.; Bogomazova, A.; Klimina, K.; Larin, A.; Zatsepin, T.; Prikazchikova, T.; Sharova, E.; Generozov, E. V.; Lagarkova, M. A.; Govorun, V. M.; Arapidi, G. P.
10.1101/2022.03.08.483320 — systems biology — Posted on 2022-07-01
3972 Impact of pre-breeding feeding practices on rabbit mammary gland development at mid-pregnancy.
Hue-Beauvais, C.; Bebin, K.; Robert, R.; Gardan-Salmon, D.; Maupin, M.; Brun, N.; Aujean, E.; Jaffrezic, F.; simon, s.; Charlier, M.; Le Provost, F.
10.1101/2022.01.17.476562 — physiology — Posted on 2022-07-01
3978 Reconstructing the functional effect of TP53 somatic mutations on its regulon using causal signalling network modelling
Triantafyllidis, C.; Barberis, A.; Miar, A.; Chartlon, P.; Hartley, F.; Van Bijsterveldt, L.; Gjerga, E.; Saez-Rodriguez, J.; Buffa, F. M.
10.1101/2022.06.23.497293 — systems biology — Posted on 2022-07-01
3980 The immunodominant protein P116 extracts cholesterol and other essential lipids
Sprankel, L.; Vizarraga, D.; Martin, J.; Manger, S.; Meier-Credo, J.; Marcos, M.; Julve, J.; Rotllan, N.; Scheffer, M. P.; Escola-Gil, J. C.; Langer, J.; Pinyol, J.; Fita, I.; Frangakis, A. S.
10.1101/2022.06.28.498018 — biophysics — Posted on 2022-07-01
3982 Organoid co-culture model of the cycling human endometrium in a fully-defined syntheticextracellular matrix reveals epithelial-stromal crosstalk
Gnecco, J. S.; Brown, A. T.; Buttrey, K.; Ives, C. S.; Goods, B. A.; Baugh, L.; Hernandez-Gordillo, V.; Loring, M.; Isaacson, K.; Griffith, L. G.
10.1101/2021.09.30.462577 — bioengineering — Posted on 2022-07-01
3983 Nanopore-only assemblies for genomic surveillance of the global priority drug-resistant pathogen, Klebsiella pneumoniae
Foster-Nyarko, E.; Cottingham, H.; Wick, R. R.; Judd, L. M.; Lam, M. M. C.; Wyres, K. L.; Stanton, T. D.; Tsang, K. K.; David, S.; Aanensen, D. M.; Brisse, S.; Holt, K. E.
10.1101/2022.06.30.498322 — genomics — Posted on 2022-07-01
3986 Transcriptional Profiles Analysis of COVID-19 and Malaria Patients Reveals Potential Biomarkers in Children
Lambert, N.; Jonas, K.-O. A.; Rissy, W. M.; Diane, U.; Murithi, K.; Peter, K.; Awe, O. I.; Dillman, A.
10.1101/2022.06.30.498338 — bioinformatics — Posted on 2022-07-01
3988 Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development
Grimm, L.; Mason, E. A.; Yu, O.; Dudczig, S.; Panara, V.; Chen, T.; Bower, N. I.; Paterson, S.; Okuda, K.; Rondon Galeano, M.; Kobayashi, S.; Senabouth, A.; Lagendijk, A.; Powell, J.; Smith, K. A.; Koltowska, K.; Hogan, B. M.
10.1101/2022.02.10.479999 — developmental biology — Posted on 2022-07-01
3991 PTEN and BRCA1 tumor suppressor loss associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in a murine model of ovarian cancer
Shakfa, N.; Li, D.; Conseil, G.; Lightbody, E. D.; Wilson-Sanchez, J.; Hamade, A.; Chenard, S.; Laight, B. J.; Asante, A.; Tyryshkin, K.; Köbel, M.; Koti, M.
10.1101/2022.06.27.497846 — immunology — Posted on 2022-07-01
3993 Noradrenergic signaling in the rodent orbitofrontal cortex is required to update goal-directed actions.
Cerpa, J.-C.; Piccin, A.; Dehove, M.; Lavigne, M.; Kremer, E. J.; Wolff, M.; Parkes, S. L.; Coutureau, E.
10.1101/2022.06.30.498245 — neuroscience — Posted on 2022-07-01
3996 Functional characterization of the Met50Val substitution in SLC30A9 as a novel case of adaptive introgression in humans
Roca-Umbert, A.; Vogel-Gonzalez, M.; Fierro-Villegas, A.; Garcia-Calleja, J.; Bosnjak, A.; Ill-Raga, G.; Herrera-Fernandez, V.; Muntane, G.; Campelo, F.; Vicente, R.; Bosch, E.
10.1101/2022.06.29.498106 — evolutionary biology — Posted on 2022-07-01
3999 RPG interacts with E3-ligase CERBERUS to mediate rhizobial infection in Lotus japonicus
Li, X.; Liu, M.; Cai, M.; Chiasson, D.; Groth, M.; Heckmann, A. B.; Wang, T. L.; Parniske, M.; Downie, J. A.; Xie, F.
10.1101/2022.06.30.498293 — cell biology — Posted on 2022-07-01
4000 The cell cycle regulator cyclin D1 modulates the activity of α4-containing GABAA receptors
Pedraza, N.; Monserrat, M. V.; Ferrezuelo, F.; Torres-Rosell, J.; Colomina, N.; Soto, D.; Esteban, J. A.; Miguez, F.; Egea, J.; Gari, E.
10.1101/2022.06.30.498219 — molecular biology — Posted on 2022-07-01
4001 Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies
de Neergaard, T.; Bläckberg, A.; Ivarsson, H.; Thomasson, S.; Kumra Ahnlide, V.; Chowdhury, S.; Khakzad, H.; Malmström, J.; Rasmussen, M.; Nordenfelt, P.
10.1101/2022.06.27.497877 — immunology — Posted on 2022-07-01
4002 IFNA pathway drives the more aggressive phenotype of KRASG12D-mutant pancreatic ductal adenocarcinomas via IFNAR1/STAT3 activation
Duda, D. G.; Inoue, K.; Schanne, D. H.; Matsui, A.; Lei, P.; Klein, S.; Aoki, S.; Taniguchi, H.; Kikuchi, H.; Chen, J.; Liu, Z.; Tsai, S. Q.; Schmidt, T. C.; Iwasaki, M.; Geidel, G.; Koch, A.; Huang, P.; Fukumura, D.; Shioda, T.; Munn, L.; Castillo, C. F.-d.; Hong, T.; Jain, R.; Liss, A.; Bardeesy, N.
10.1101/2022.06.29.497540 — cancer biology — Posted on 2022-07-01
4003 Elevated FOXG1 supports exit from quiescence in neural stem cells through FoxO6
Ferguson, K. M.; Blin, C.; Diaz, C. G.; Bulstrode, H.; Bressan, R.; McCarten, K.; Pollard, S.
10.1101/2022.06.30.498283 — cancer biology — Posted on 2022-07-01
4005 Evaluation of EN2 Gene as a Potential Biomarker for Bladder Cancer
Aldoghachi, A. F.; Baharudin, A.; Ahmad, U.; Choy, C. S.; Aik, O. T.; Yunus, R.; Razack, A.; Yusoff, K.; Veerakumarasivam, A.
10.1101/2022.06.28.497337 — cancer biology — Posted on 2022-07-01
4006 Pro-apoptotic and anti-invasive properties underscore the tumor suppressing impact of myoglobin on subset of human breast cancer cells
Aboouf, M. A.; Armbruster, J.; Thiersch, M.; Guscetti, F.; Kristiansen, G.; Schraml, P.; Bicker, A.; Petry, R.; Hankeln, T.; Gassmann, M.; Gorr, T. A.
10.1101/2022.06.30.498102 — cancer biology — Posted on 2022-07-01
4014 High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro.
Shechtman, L. A.; Scott, J. K.; Larson, E. D.; Isner, T. J.; Johnson, B. J.; Gaillard, D.; Dempsey, P. J.; Barlow, L. A.
10.1101/2022.06.30.498302 — developmental biology — Posted on 2022-07-01
4015 Novel cell- and stage-specific transcriptional signatures defining Drosophila neurons, glia and hemocytes
Sakr, R.; Cattenoz, P. B.; Pavlidaki, A.; Ciapponi, L.; Marzullo, M.; Hariharan, N.; Mukherjee, T.; Giangrande, A.
10.1101/2022.06.30.498263 — developmental biology — Posted on 2022-07-01
4017 Single-Cell RNA-seq of Heart Reveals Intercellular Communication Drivers of Myocardial Fibrosis in Diabetic Mice
Zhang, Z.; Li, W.; Lou, X.; Zha, Y.; Zha, J.; Hong, L.; Xie, Z.; Yang, S.; Wang, C.; An, J.; Qiao, S.
10.1101/2022.06.29.498129 — cell biology — Posted on 2022-07-01
4018 The Structural Flexibility of MAD1 Facilitates the Assembly of the Mitotic Checkpoint Complex
Chen, C.; Piano, V.; Alex, A.; Han, S.; Huis in t Veld, P. J.; Roy, B.; Musacchio, A.; Joglekar, A.
10.1101/2022.06.29.498198 — cell biology — Posted on 2022-07-01
4019 A Novel Homeostatic Mechanism Tunes PI(4,5)P2-dependent Signaling at the Plasma Membrane
Wills, R. C.; Doyle, C. P.; Zewe, J. P.; Pacheco, J.; Hansen, S. D.; Hammond, G. R.
10.1101/2022.06.30.498262 — cell biology — Posted on 2022-07-01
4020 Pharmaco-Pheno-Multiomic Integration Reveals Biomarker Profiles and Therapeutic Response Prediction Models in Leukemia and Ovarian Cancer
Silberberg, G.; Walling, B.; Wesa, A.; Audia, A.; Sloma, I.; Zeng, Y.; Han, G.; Tabg, J.; Pammer, P.; Bakayoko, A.; Ren, X.; Ciznadija, D.; Ren, X.; Vishwakarma, B.; Mosesson, Y.; Zipeto, M.; RItchie, M.
10.1101/2022.06.14.495846 — cancer biology — Posted on 2022-07-01
4021 LipIDens: Simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins.
Ansell, T. B.; Song, W.; Coupland, C. E.; Carrique, L.; Corey, R. A.; Duncan, A. L.; Cassidy, C. K.; Guerts, M. M. G.; Rasmussen, T.; Ward, A. B.; Siebold, C.; Stansfeld, P. J.; Sansom, M.
10.1101/2022.06.30.498233 — biophysics — Posted on 2022-07-01
4027 The spindle orienting machinery requires activation, not just localization
Neville, K. E.; Finegan, T. M.; Lowe, N.; Bellomio, P. M.; Na, D.; Bergstralh, D. T.
10.1101/2022.06.29.498167 — cell biology — Posted on 2022-07-01
4028 Enhanced hippocampal LTP but typical NMDA receptor and AMPA receptor function in a novel rat model of CDKL5 deficiency disorder
Simoes de Oliveira, L.; O'Leary, H. E.; Nawaz, S.; Loureiro, R.; Davenport, E. C.; Baxter, P.; Dando, O. R.; Perkins, E.; Booker, S. A.; Hardingham, G. E.; Cousin, M. A.; Chattarji, S. A.; Benke, T. A.; Wyllie, D. J.; Kind, P. C.
10.1101/2022.06.29.497927 — neuroscience — Posted on 2022-07-01