bioRxiv directory

Castranio, E. L.; Hasel, P.; Haure-Mirande, J.-V.; Ramirez, A. V.; Hamilton, B. W.; Kim, R. D.; Wang, M.; Zhang, B.; Gandy, S.; Liddelow, S. A.; Ehrlich, M. E.

10.1101/2022.04.29.490076 — neuroscience — Posted on 2022-04-30

3 Generalizing predictions to unseen sequencing profiles via deep generative models

Oh, M.; ZHANG, L.

10.1101/2021.05.06.443027 — bioinformatics — Posted on 2022-04-30

4 Genetic epidemiology of human neutrophil antigen variants suggest significant global variability

Rophina, M.; Scaria, V.

10.1101/2022.04.28.489826 — genomics — Posted on 2022-04-30

5 An improved pipeline for reprogramming human induced pluripotent stem cells with TET1

Motono, M.; Hiraki-Kamon, K.; Kamon, M.; Kiyosawa, H.; Kondo, Y.; Kato, H.

10.1101/2022.04.29.489839 — cell biology — Posted on 2022-04-30

6 Experimental Guidance for Discovering Genetic Networks through Iterative Hypothesis Reduction on Time Series

Cummins, B.; Motta, F. C.; Moseley, R. C.; Deckard, A.; Campione, S.; Gedeon, T.; Mischaikow, K.; Haase, S. B.

10.1101/2022.04.28.489981 — systems biology — Posted on 2022-04-30

7 A novel computational approach to identify cancer cells in scRNA-seq data

Gasper, W. K.; Rossi, F.; Ligorio, M.; Ghersi, D.

10.1101/2022.04.28.489880 — bioinformatics — Posted on 2022-04-30

8 Drug-like small molecules that inhibit expression of the oncogenic microRNA-21

Shortridge, M. D.; Chaubey, B.; Zhang, H. J.; Pavelitz, T.; Olsen, G. L.; Calin, G.; Varani, G.

10.1101/2022.04.30.490150 — biochemistry — Posted on 2022-04-30

9 MCIBox: A Toolkit for Single-molecule Multi-way Chromatin Interaction Visualization and Micro-Domains Identification

Tian, S. Z.; Li, G.; Ning, D.; Jing, K.; Xu, Y.; Yang, Y.; Fullwood, M. J.; Yin, P.; Huang, G.; Plewczynski, D.; Wang, W.; Zhai, J.; Wang, Z.; Dai, Z.; Lin, Y.; Chen, W.; Zheng, M.

10.1101/2022.04.28.489957 — genomics — Posted on 2022-04-30

10 Effects of calcium-regulated autophagy on Candidatus Liberibacter solanacearum in carrot psyllid midguts

Sarkar, P.; Jassar, O.; Ghanim, M.

10.1101/2022.04.30.490068 — molecular biology — Posted on 2022-04-30

11 EndophilinA-dependent coupling between activity-dependent calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation

Bademosi, A. T.; Decet, M.; Kuenen, S.; Calatayud, C.; Swerts, J.; Gallego, S. F.; Schoovaerts, N.; Louros, N.; Martin, E.; Karamanou, S.; Sibarita, J.-B.; Vints, K.; Gounko, N. V.; Meunier, F. A.; Economou, A.; Versees, W.; Rousseau, F.; Schymkowitz, J.; Soukup, S.-F.; Verstreken, P.

10.1101/2022.04.29.490010 — neuroscience — Posted on 2022-04-30

12 Local field potentials and single unit dynamics in motor cortex of unconstrained macaques during different behavioral states

Yun, R.; Mishler, J.; Perlmutter, S. I.; Rao, R. P. N.; Fetz, E. E.

10.1101/2022.04.28.489967 — neuroscience — Posted on 2022-04-30

13 Visuospatial attention revamps cortical processing of sound: restrict stimulus uncertainty

Cervantes Constantino, F.; Sanchez-Costa, T.; Cipriani, G. A.; Carboni, A.

10.1101/2020.07.30.229948 — neuroscience — Posted on 2022-04-30

14 Chemical ecology of Himalayan eggplant variety's antixenosis: Identification of geraniol as an oviposition deterrent against the eggplant shoot and fruit borer

Ghosh, R.; Metze, D.; Shaikh, M.; Deshpande, A.; Firake, D. M.; Pandit, S.

10.1101/2022.04.28.489959 — plant biology — Posted on 2022-04-30

15 NSF/αSNAP2-mediated cis-SNARE complex disassembly precedes membrane fusion generating the cell plate during Arabidopsis cytokinesis

Park, M.; Mayer, U.; Juergens, G.

10.1101/2022.04.29.490041 — plant biology — Posted on 2022-04-30

16 Effects of lowered o and membrane depolarization on the Ca2+ transients of fast skeletal muscle fibers. Implications for muscle fatigue.

Quinonez, M.; DIFRANCO, M.

10.1101/2022.04.28.489961 — physiology — Posted on 2022-04-30

17 MEK inhibitor resistance in lung cancer cells associated with addiction to sustained ERK suppression

Farnsworth, D. A.; Inoue, Y.; Johnson, F. D.; de Rappard-Yuswack, G.; Lu, D.; Shi, R.; Somwar, R.; Ladanyi, M.; Unni, A. M.; Lockwood, W.

10.1101/2022.04.29.490009 — cancer biology — Posted on 2022-04-30

18 Protein complex prediction using Rosetta, AlphaFold, and mass spectrometry covalent labeling

Drake, Z. C.; Seffernick, J. T.; Lindert, S.

10.1101/2022.04.30.490108 — biophysics — Posted on 2022-04-30

19 Direct Visualization of Translesion DNA Synthesis Polymerase IV at the Replisome

Pham, T. M.; Gilhooly, N.; Marians, K. J.; Kowalczykowski, S. C.

10.1101/2022.04.23.489275 — biochemistry — Posted on 2022-04-30

20 Dead infant carrying by chimpanzee mothers in the Budongo Forest

Soldati, A.; Fedurek, P.; Crockford, C.; Adue, S.; Akankwasa, J. W.; Asiimwe, C.; Asua, J.; Atayo, G.; Chandia, B.; Freymann, E.; Fryns, C.; Muhumuza, G.; Taylor, D.; Zuberbuhler, K.; Hobaiter, C.

10.1101/2021.12.22.473786 — animal behavior and cognition — Posted on 2022-04-30

21 Inferring sources of suboptimality in perceptual decision making using a causal inference task

Shivkumar, S.; Cappelloni, M. S.; Maddox, R. K.; Haefner, R. M.

10.1101/2022.04.28.489925 — animal behavior and cognition — Posted on 2022-04-30

22 A chromosome-length genome assembly and annotation of blackberry (Rubus argutus, cv. Hillquist)

Bruna, T.; Aryal, R.; Dudchenko, O.; Sargent, D. J.; Mead, D.; Buti, M.; Cavallini, A.; Hytönen, T.; Andres, J.; Pham, M.; Weisz, D.; Mascagni, F.; Usai, G.; Natali, L.; Bassil, N.; Fernandez, G. E.; Lomsadze, A.; Armour, M.; Olukolu, B. A.; Poorten, T. J.; Britton, C.; Davik, J.; Ashrafi, H.; Aiden, E. L.; Borodovsky, M.; Worthington, M. L.

10.1101/2022.04.28.489789 — genomics — Posted on 2022-04-30

23 The mutational landscape of single neurons and oligodendrocytes reveals evidence of inflammation-associated DNA damage in multiple sclerosis

Motyer, A.; Jackson, S.; Yang, B.; Harliwong, I.; Tian, W.; Shiu, W.; Shao, Y.; Wang, B.; McLean, C.; Barnett, M.; Kilpatrick, T. J.; Leslie, S.; Rubio, J. P.

10.1101/2022.04.30.490132 — genomics — Posted on 2022-04-30

24 Adaptation of the eyes of grass puffer (Takifugu niphobles) to the riverine and marine environments

Osada, M.; Terai, Y.

10.1101/2022.04.28.489969 — evolutionary biology — Posted on 2022-04-30

25 Dispersal between interconnected patches can reduce the total population size

Vortkamp, I.; Kost, C.; Hermann, M.; Hilker, F. M.

10.1101/2022.04.28.489935 — ecology — Posted on 2022-04-30

26 Species packing and the latitudinal gradient in beta-diversity

Cao, K.; Condit, R.; Mi, X.; Chen, L.; Ren, H.; Xu, W.; Burslem, D. F. R. P.; Cai, C.; Cao, M.; Chang, L.-W.; Chu, C.; Cui, F.; Du, H.; Ediriweera, S.; Gunatilleke, C. S. V.; Gunatilleke, I. U. A. N.; Hao, Z.; Jin, G.; Li, J.; Li, B.; Li, Y.; Liu, Y.; Ni, H.; O'Brien, M. J.; Qiao, X.; Shen, G.; Tian, S.; Wang, X.; Xu, H.; Xu, Y.; Yang, L.; Yap, S. L.; Lian, J.; Ye, W.; Yu, M.; Su, S.-H.; Chang-Yang, C.-H.; Guo, Y.; Li, X.; Zeng, F.; Zhu, D.; Zhu, L.; Sun, I.-F.; Ma, K.; Svenning, J.-C.

10.1101/2020.07.14.200006 — ecology — Posted on 2022-04-30

27 Atlantic cod as an indicator of rapid climate change

Choi, J. S.

10.1101/2022.04.21.488963 — ecology — Posted on 2022-04-30

28 Characterization of the DNA binding domain of StbA, a key protein of a new type of DNA segregation system

Quebre, V.; del Campo, I.; Cuevas, A.; Siguier, P.; Rech, J.; Phan Thai Nguyen, L.; hoang, b.; Cornet, F.; bouet, j.-y.; Moncalian, G.; de la Cruz, F.; Guynet, C.

10.1101/2022.04.29.490116 — microbiology — Posted on 2022-04-30

29 A guide for membrane potential measurements in Gram-negative bacteria using voltage-sensitive dyes

Buttress, J. A.; Halte, M.; te Winkel, J. D.; Erhardt, M.; Popp, P. F.; Strahl, H.

10.1101/2022.04.30.490130 — microbiology — Posted on 2022-04-30

30 Evidence for the presence and diagnostic utility of SPM in human peripheral blood

Dalli, J.; Gomez, E. A.; Serhan, C. N.

10.1101/2022.04.28.489064 — immunology — Posted on 2022-04-30

31 BMAL1 loss in oligodendroglial lineage cells dysregulates myelination and sleep

Rojo, D.; Badner, A.; Dal Cengio, L.; Kim, S.; Sakai, N.; Greene, J.; Eisinger, E.; Arellano-Garcia, C.; Mehl, L. C.; Gumma, M. E.; Soyk, R. L.; Ransom, J.; Weigel, M. K.; Yalcin, B.; Jones, S. E.; Ollila, H. M.; Nishino, S.; Gibson, E. M.

10.1101/2022.04.28.489946 — neuroscience — Posted on 2022-04-30

32 Pharmacological blockade of muscle afferents and perception of effort: a systematic review with meta-analysis

Bergevin, M.; Steele, J.; Payen de la Garanderie, M.; Feral-Basin, C.; Marcora, S. M.; Rainville, P.; Caron, J. G.; Pageaux, B.

10.1101/2021.12.23.474027 — neuroscience — Posted on 2022-04-30

33 Envelope analysis of the human alpha rhythm reveals EEG Gaussianity

Hidalgo, V. M.; Diaz, J.; Mpodozis, J.; Letelier, J.-C.

10.1101/2021.03.31.437785 — neuroscience — Posted on 2022-04-30

34 Early steps of embryo implantation are regulated by exchange of extracellular vesicles between the embryo and the endometrium

Szuszkiewicz, J.; Myszczynski, K.; Reliszko, Z. P.; Heifetz, Y.; Kaczmarek, M. M.

10.1101/2022.04.28.489970 — physiology — Posted on 2022-04-30

35 Genomic analyses identify significant biological processes in DDX21-mediated colorectal cancer cells

Wang, X.; Zhang, D.; Wang, M.

10.1101/2022.04.28.489934 — bioinformatics — Posted on 2022-04-30

36 Sorting Single T cells based on Secreted Cytokines and Surface Markers using Hydrogel Nanovials

Koo, D.; Dimatteo, R.; Lee, S.; de Rutte, J.; Di Carlo, D.

10.1101/2022.04.28.489940 — bioengineering — Posted on 2022-04-30

37 Full-length dystrophin is expressed across human tissues and DMD downregulation commonly occurring in tumours coincides with Duchenne-like molecular alterations

Alnassar, N.; Borczyk, M.; Tsagkogeorga, G.; Korostynski, M.; Han, N.; Gorecki, D. C.

10.1101/2022.04.04.486990 — genetics — Posted on 2022-04-30

38 Partial refuges from biological control due to intraspecific variation in protective host traits: a case study with the egg parasitoid Trissolcus japonicus

Abram, P. K.; Haye, T.; Clarke, P.; Grove, E.; Thiessen, J.; Gariepy, T. D.

10.1101/2022.04.28.489927 — ecology — Posted on 2022-04-30

39 Long Term Virucidal Activity of Rosin Soap on Surfaces

Bamford, C. G. G.; Bell, S. H.; Fairley, D. J.; Kettunen, H.; Vuorenmaa, J.; Orte, J.; McGrath, J.

10.1101/2022.04.29.490117 — microbiology — Posted on 2022-04-30

40 5' Untranslated mRNA Regions Allow Bypass of Host Cell Translation Inhibition by Legionella pneumophila

Lipo, E.; Asrat, S.; Huo, W.; Sol, A.; Fraser, C. S.; Isberg, R. R.

10.1101/2022.04.29.490120 — microbiology — Posted on 2022-04-30

41 QuasiFlow: a bioinformatic tool for genetic variability analysis from next generation sequencing data

Seoane, P.; Diaz-Martinez, L.; Viguera, E.; Claros, M. G.; Grande-Perez, A.

10.1101/2022.04.05.487169 — bioinformatics — Posted on 2022-04-30

42 Morphological integration during postnatal ontogeny: implications for evolutionary biology

Hubbe, A.; Garcia, G.; Sebastiao, H.; Porto, A.; Machado, F. A.; Cheverud, J.; Marroig, G.

10.1101/2021.07.13.452198 — developmental biology — Posted on 2022-04-30

43 HIV-1 Rev-RRE Functional Activity in Primary Isolates is Highly Dependent on Minimal Context-Dependent Changes in Rev

Dzhivhuho, G.; Holsey, J.; Honeycutt, E.; O'Farrell, H.; Rekosh, D.; Hammmarskjold, M.-L. A.; Jackson, P. E. H.

10.1101/2022.04.29.490105 — microbiology — Posted on 2022-04-30

44 The "LINC" in between Delta40p53-miRNA axis in the regulation of cellular processes

Pal, A.; Das, S.

10.1101/2022.04.28.489891 — cancer biology — Posted on 2022-04-30

45 Revisiting regulatory decoherence and phenotypic integration: accounting for temporal bias in co-expression analyses

Cai, H.; Des Marais, D.

10.1101/2021.04.08.438389 — genetics — Posted on 2022-04-30

46 Inka2, a novel Pak4 inhibitor, regulates actin dynamics in dendritic spine development

Yamada, S.; Mizukoshi, T.; Tokunaga, A.; Sakakibara, S.-i.

10.1101/2022.03.17.484704 — neuroscience — Posted on 2022-04-30

47 Serotonin signals through postsynaptic Gαq, Trio RhoGEF, and diacylglycerol to promote C. elegans egg-laying circuit activity and behavior

Dhakal, P.; Chaudhry, S.; Signorelli, R.; Collins, K. M.

10.1101/2021.05.08.443256 — neuroscience — Posted on 2022-04-30

48 Two tales of one neural link predict blind individual's Braille reading proficiency

WANG, R.; GONG, J.; ZHAO, C.; XU, Y.; HONG, B.

10.1101/2021.04.12.439380 — neuroscience — Posted on 2022-04-30

49 Synthetic periphyton as a model system to understand species dynamics in complex microbial freshwater communities

Lamprecht, O.; Wagner, B.; Derlon, N.; Tlili, A.

10.1101/2021.10.31.466637 — synthetic biology — Posted on 2022-04-30

50 Impact of energy limitations on function and resilience in long-wavelength Photosystem II

Viola, S.; Roseby, W.; Santabarbara, S.; Nuernberg, D. J.; Assuncao, R.; Dau, H.; Selles, J.; Boussac, A.; Fantuzzi, A.; Rutherford, A. W.

10.1101/2022.04.05.486971 — plant biology — Posted on 2022-04-30

51 Phenomics data processing: Extracting dose-response curve parameters from high-resolution temperature courses and repeated field-based wheat height measurements

Roth, L.; Piepho, H.-P.; Hund, A.

10.1101/2021.07.23.453040 — plant biology — Posted on 2022-04-30

52 Arnold tongue entrainment reveals dynamicalprinciples of the embryonic segmentation clock

Sanchez, P. G. L.; Mochulska, V.; Mauffette Denis, C.; Moenke, G.; Tomita, T.; Tsuchida-Straeten, N.; Petersen, Y.; Sonnen, I.; Francois, P.; Aulehla, A.

10.1101/2021.10.20.465101 — developmental biology — Posted on 2022-04-30

53 The activation of mGluR4 rescues parallel fiber LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome

Martin, R.; Suarez-Pinilla, A. S.; Garcia-Font, N.; Laguna-Luque, M. L.; Lopez-Ramos, J. C.; Oset-Gasque, M. J.; Gruart, A.; Delgado-Garcia, J. M.; Torres, M.; Sanchez-Prieto, J.

10.1101/2022.04.29.490046 — neuroscience — Posted on 2022-04-30

54 GB_SynP: a modular dCas9-regulated synthetic promoter collection for fine-tuned recombinant gene expression in plants.

Moreno-Gimenez, E.; Selma, S.; Calvache, C. A.; Orzaez, D.

10.1101/2022.04.28.489949 — synthetic biology — Posted on 2022-04-30

55 PILS proteins provide a homeostatic feedback on auxin signaling output

Feraru, E.; Feraru, M. I.; Moulinier-Anzola, J.; Schwihla, M.; Ferreira Da Silva Santos, J.; Sun, L.; Waidmann, S.; Korbei, B.; Kleine-Vehn, J.

10.1101/2022.04.28.489893 — plant biology — Posted on 2022-04-30

56 Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation

de Assis, L. V.; Harder, L.; Lacerda, J. T.; Parsons, R.; Kaehler, M.; Cascorbi, I.; Nagel, I.; Rawashdeh, O.; Mittag, J.; Oster, H.

10.1101/2022.04.28.489909 — physiology — Posted on 2022-04-30

57 The replication stress response suppresses mutation rates in mismatch repair deficient budding yeast and human cancers

Shrikhande, A. M.; Soerensen, S. G.; Offman, J.; Domanska, B.; Pedersen, J. S.; Hoffmann, E. R.

10.1101/2022.04.28.489863 — cancer biology — Posted on 2022-04-30

58 Machine learning-based detection of label-free cancer stem-like cell fate

Chambost, A. J.; Berabez, N.; Cochet-Escartin, O.; Ducray, F.; GABUT, M.; Isaac, C.; Martel, S.; Idbaih, a.; Rousseau, D.; Meyronet, D.; Monnier, S.

10.1101/2022.04.27.489645 — bioinformatics — Posted on 2022-04-30

59 Divergence of trafficking and polarity mechanisms for PIN auxin transporters during land plant evolution

Tang, H.; Lu, K.-J.; Cheng, Y.-L.; Tu, S.-L.; Friml, J.

10.1101/2022.04.28.489888 — evolutionary biology — Posted on 2022-04-30

60 Thyroid hormone and ALK5 inhibitor improve maturation of human pluripotent stem cell derived hepatocytes

Withey, S.; Gerrard, D.; Leeson, H.; Atkinson-Dell, R.; Harrison, S.; Baxter, M.; Wolvetang, E. J.; Hanley, N.

10.1101/2022.04.28.489845 — developmental biology — Posted on 2022-04-30

61 Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells

Garcia-Parajo, M. F.; Gutierrez-Martinez, E.; Benet Garrab, S.; Mateos, N.; Erkiziac, I.; Nieto-Garai, J. A.; Lorizate, M.; Manzo, C.; Campelo, F.; Izquierdo-Useros, N.; Martinez-Picado, J.

10.1101/2022.04.28.489919 — cell biology — Posted on 2022-04-30

62 MEIG1/PACRG associated and non-associated functions of axonemal dynein light intermediate polypeptide 1 (DNALI1) in mammalian spermatogenesis

Yap, Y. T.; Li, W.; Huang, Q.; Zhou, Q.; Zhang, D.; Mladenovic-Lucas, L.; Granneman, J. G.; Williams, D. C.; Hess, R.; Toure, A.; Zhang, Z.

10.1101/2022.04.28.489920 — cell biology — Posted on 2022-04-30

63 Hyperimmune bovine colostrum containing lipopolysaccharide antibodies (Imm124-E) has a non-detrimental effect on gut microbial communities in unchallenged mice.

Gore, R.; Mohsenipour, M.; Wood, J. L.; Balasuriya, G. K.; Hill-Yardin, E. L.; Franks, A. E.

10.1101/2022.04.28.489964 — microbiology — Posted on 2022-04-30

64 SPTLC1 variants associated with childhood onset amyotrophic lateral sclerosis produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

Lone, M. A.; Aaltonen, M. J.; Zidell, A.; Pedro, H. F.; Saute, J. A. M.; Mathew, S.; Mohassel, P.; Bonnemann, C.; Shoubridge, E. A.; Hornemann, T.

10.1101/2022.04.29.490031 — biochemistry — Posted on 2022-04-30

65 Predicting the impact of sequence motifs on gene regulation using single-cell data

Hepkema, J.; Lee, N. K.; Stewart, B. J.; Ruangroengkulrith, S.; Charoensawan, V.; Clatworthy, M. R.; Hemberg, M.

10.1101/2020.11.26.400218 — bioinformatics — Posted on 2022-04-30

66 An improved pipeline for reprogramming human induced pluripotent stem cells with TET1

Kato, H.; Motono, M.; Hiraki-Kamon, K.; Kamon, M.; Kiyosawa, H.; Kondo, Y.

10.1101/2022.04.29.489839 — cell biology — Posted on 2022-04-30

67 Intracellular injection of brain extracts from Alzheimer's disease patients trigger unregulated Ca2+ release from intracellular stores that hinders cellular bioenergetics

Pensalfini, A.; Umar, A. R.; Glabe, C. G.; Parker, I.; Ullah, G.; Demuro, A.

10.1101/2022.04.29.490088 — cell biology — Posted on 2022-04-30

68 Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

Mastrototaro, G.; Carullo, P.; Zhang, J.; Scellini, B.; Piroddi, N.; Nemska, S.; Filomena, M. C.; Serio, S.; Otey, C. A.; Tesi, C.; Emrich, F.; Linke, W. A.; Poggesi, C.; Boncompagni, S.; Bang, M.-L.

10.1101/2022.04.29.489866 — molecular biology — Posted on 2022-04-30

69 Humanization and Expression of IgG and IgM Antibodies in Plants as Potential Diagnostic Reagents for Valley Fever

Jugler, C.; Grill, F. J.; Grys, T. E.; Lake, D. F.; Chen, Q.

10.1101/2022.04.27.489777 — immunology — Posted on 2022-04-30

70 The Features Underlying the Memorability of Objects

Kramer, M. A.; Bainbridge, W. A.; Hebart, M. N.; Baker, C. I.

10.1101/2022.04.29.490104 — neuroscience — Posted on 2022-04-30

71 DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas

Carey, H.; Pegios, M.; Martin, L.; Saleeba, C.; Turner, A.; Everett, N.; Puchades, M. A.; Bjaalie, J. G.; McMullan, S.

10.1101/2022.04.28.489953 — neuroscience — Posted on 2022-04-30

72 Common Permutation Methods in Animal Social Network Analysis Do Not Control for Non-independence

Hart, J. D. A.; Weiss, M. N.; Brent, L. J. N.; Franks, D. W.

10.1101/2021.06.04.447124 — animal behavior and cognition — Posted on 2022-04-30

73 H4K16ac activates transcription of transposable elements and contribute to their cis regulatory function

Pal, D.; Patel, M.; Boulet, F.; Sundarraj, J.; Grant, O. A.; Branco, M. R.; Basu, S.; Zabet, N. R.; Scaffidi, P.; Pradeepa, M. M.

10.1101/2022.04.29.488986 — genomics — Posted on 2022-04-30

74 Comparison of R9.4.1/Kit10 and R10/Kit12 Oxford Nanopore flowcells and chemistries in bacterial genome reconstruction

Sanderson, N. D.; Kapel, N.; Rodger, G.; Webster, H.; Lipworth, S.; Street, T. L.; Peto, T. E.; Crook, D. W.; Stoesser, N.

10.1101/2022.04.29.490057 — genomics — Posted on 2022-04-30

75 Transcription factor binding sites are frequently under accelerated evolution in primates

Zhang, X.; Huang, Y.-F.

10.1101/2022.04.29.490094 — evolutionary biology — Posted on 2022-04-30

76 Aβ42 and Aβ40 oligomers form transient and persistent pores with different time evolutions and toxicities

Shah, S. I.; Parker, I.; Ullah, G.; Demuro, A.

10.1101/2022.04.29.490101 — cell biology — Posted on 2022-04-30

77 Histone deacetylase 6 inhibition promotes microtubule acetylation and facilitates autophagosome-lysosome fusion in dystrophin-deficient mdx mice

Agrawal, A.; Clayton, E. L.; Cavazos, C. L.; Clayton, B. A.; Rodney, G. G.

10.1101/2022.04.29.490072 — cell biology — Posted on 2022-04-30

78 Nipsnap1- A Regulatory Factor Required for Long-Term Maintenance of Non-Shivering Thermogenesis

Liu, Y.; Qu, Y.; Cheng, C.; Tsai, P.-Y.; Edwards, K.; Xue, S.; Pandit, S.; Eguchi, S.; Sanghera, N.; Barrow, J. J.

10.1101/2022.04.29.490099 — molecular biology — Posted on 2022-04-30

79 The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases

Chen, Z.; Reynolds, R. H.; Pardiñas, A. F.; Gagliano Taliun, S. A.; van Rheenen, W.; Lin, K.; Shatunov, A.; Gustavsson, E. K.; Fogh, I.; Jones, A. R.; Robberecht, W.; Corcia, P.; Chio, A.; Shaw, P.; Morrison, K. E.; Veldink, J.; van den Berg, L. H.; Shaw, C. E.; Powell, J. F.; Silani, V.; Hardy, J.; Houlden, H.; Owen, M. J.; Turner, M.; Ryten, M.; Al-Chalabi, A.

10.1101/2022.04.29.490053 — neuroscience — Posted on 2022-04-30

80 A novel hidden Markov approach to studying dynamic functional connectivity states in human neuroimaging

Hussain, S.; Langley, J.; Seitz, A. R.; Hu, X.; Peters, M. A. K.

10.1101/2022.02.02.478844 — neuroscience — Posted on 2022-04-30

81 Metabolically-Incorporated Deuterium in Myelin Localized by Neutron Diffraction and Identified by Mass Spectrometry

Baumann, A.; Denninger, A. R.; Domin, M.; Deme, B.; Kirschner, D. A.

10.1101/2021.12.17.473245 — neuroscience — Posted on 2022-04-30

82 Robustness of the autophagy pathway to somatic copy number losses

Polo, P.; Gremke, N.; Stiewe, T.; Wanzel, M.

10.1101/2022.04.29.489531 — cancer biology — Posted on 2022-04-30

83 Cells function as a ternary logic gate to decide migration direction under integrated chemical and fluidic cues

Moon, H.-r.; Saha, S.; Mugler, A.; Han, B.

10.1101/2022.04.28.489798 — biophysics — Posted on 2022-04-30

84 Nanobodies identify an activated state of the TRIB2 pseudokinase

Jamieson, S. A.; Pudjihartono, M.; Horne, C.; Day, R. C.; Murphy, J. M.; Mace, P. D.

10.1101/2022.04.29.489987 — biochemistry — Posted on 2022-04-30

85 Selenocyanate Derived Se-Incorporation into the Nitrogenase Fe Protein Cluster

Buscagan, T. M.; Kaiser, J. T.; Rees, D. C.

10.1101/2022.04.29.490034 — biochemistry — Posted on 2022-04-30

86 CEP162 deficiency causes human retinal degeneration and reveals a dual role inciliogenesis and neurogenesis

Nuzhat, N.; Van Schil, K.; Liakopoulos, S.; Bauwens, M.; Duenas Rey, A.; Käseberg, S.; Jäger, M.; Willer, J. R.; Winter, J.; Truong, H.; Gruartmoner, N.; Van Heetvelde, M.; Wolf, J.; Merget, R.; Grasshoff-Derr, S.; Van Dorpe, J.; Hoorens, A.; Stöhr, H.; Mansard, L.; Roux, A.-F.; Langmann, T.; Dannhausen, K.; Rosenkranz, D.; Wissing, K. M.; Van Lint, M.; Rossmann, H.; Häuser, F.; Nürnberg, P.; Thiele, H.; Zechner, U.; Pearring, J. N.; De Baere, E.; Bolz, H. J.

10.1101/2021.11.23.469779 — genetics — Posted on 2022-04-29

87 New insights from short and long reads sequencing to explore cytochrome b variants of Plasmopara viticola populations collected in vineyard and related to resistance to complex III inhibitors

Cherrad, S.; Gillet, B.; Dellinger, J.; Bellaton, L.; Roux, P.; Hernandez, C.; Steva, H.; Perrier, L.; Vacher, S.; Hughes, S.

10.1101/2022.04.29.490075 — evolutionary biology — Posted on 2022-04-29

88 Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure

Souque, C.; Escudero, J. A.; MacLean, C.

10.1101/2022.04.29.490043 — evolutionary biology — Posted on 2022-04-30

89 The evolution of recombination in self-fertilizing organisms

Stetsenko, R.; Roze, D.

10.1101/2022.02.24.481800 — evolutionary biology — Posted on 2022-04-30

90 Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

Porpiglia, E.; Mai, T.; Kraft, P.; Holbrook, C. A.; De Morree, A.; Gonzalez, V. D.; Hilgendorf, K.; Fresard, L.; Trejo, A.; Bhimaraju, S.; Jackson, P. K.; Fantl, W. J.; Blau, H. M.

10.1101/2022.04.29.489435 — cell biology — Posted on 2022-04-29

91 Actin cytoskeleton signaling via MRTF/SRF entrains circadian clock

Ma, K.; Xiong, X.; Li, W.; Nam, J.; Qu, M.; Kay, S.

10.1101/2022.04.29.490111 — cell biology — Posted on 2022-04-30

92 Novel CRISPR-based detection of Leishmania species

Duenas Villavicencio, E. A.; Nakamoto, J. A.; Cabrera Sosa, L. E.; Huaihua Puma, P.; Cruz Saldarriaga, M. E.; Arevalo Zelada, J.; Milon Mayer, P.; Adaui Sicheri, V.

10.1101/2022.04.29.490093 — molecular biology — Posted on 2022-04-29

93 In situ structure of a dimeric hibernating ribosome from a eukaryotic intracellular pathogen

McLaren, M.; Gil Diez, P.; Isupov, M. N.; Conners, R.; Gambelli, L.; Gold, V.; Walter, A.; Connell, S. R.; Williams, B.; Daum, B.

10.1101/2022.04.29.490036 — molecular biology — Posted on 2022-04-30

94 You will know by its tail: a method for quantification of heterogeneity of bacterial populations using single cell MIC profiling

Pacocha, N.; Zapotoczna, M.; Makuch, K.; Boguslawski, J.; Garstecki, P.

10.1101/2022.04.29.490018 — microbiology — Posted on 2022-04-29

95 Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals

Labaronne, E.; Decimo, D.; Bertrand, L.; Guiguettaz, L.; Sohier, T. J.; Cluet, D.; Vivet-Boubou, V.; Dahoui, C.; Francois, P.; Hatin, I.; Lambotte, O.; Samri, A.; Autran, B.; Etienne, L.; Goujon, C.; Paillart, J.-C.; Namy, O.; Ramirez, B. C.; Ohlmann, T.; Moris, A.; Ricci, E.

10.1101/2022.04.29.489990 — microbiology — Posted on 2022-04-29

96 A quorum sensing-regulated type VI secretion system containing multiple nonredundant VgrG proteins is required for interbacterial competition in Chromobacterium violaceum

Alves, J. A.; Leal, F. C.; Previato-Mello, M.; da Silva Neto, J. F.

10.1101/2022.04.29.490089 — microbiology — Posted on 2022-04-29

97 STAMP: Simultaneous Training and Model Pruning for Low Data Regimes in Medical Image Segmentation

Dinsdale, N. K.; Jenkinson, M.; Namburete, A. I.

10.1101/2021.11.26.470124 — neuroscience — Posted on 2022-04-29

98 Direct brain recordings reveal continuous encoding of structure in random stimuli

Fuhrer, J.; Glette, K.; Ivanovic, J.; Larsson, P. G.; Bekinschtein, T. A.; Kochen, S.; Knight, R. T.; Torresen, J.; Solbakk, A.-K.; Endestad, T.; Blenkmann, A.

10.1101/2021.10.01.462295 — neuroscience — Posted on 2022-04-29

99 Scale-free behavioral dynamics directly linked with scale-free cortical dynamics

Jones, S. A.; Barfield, J. H.; Norman, K.; Shew, W. L.

10.1101/2021.05.12.443799 — neuroscience — Posted on 2022-04-29

100 Measuring competitive exclusion in non-small cell lung cancer

Farrokhian, N.; Maltas, J.; Dinh, M.; Durmaz, A.; Ellsworth, P.; Hitomi, M.; McClure, E.; Marusyk, A.; Kaznatcheev, A.; Scott, J. G.

10.1101/2020.09.18.303966 — cancer biology — Posted on 2022-04-29

101 Lipocalin 2 upregulation mediates the detrimental effects of therapy-induced senescence in breast cancer cells.

Morales-Valencia, J.; Lau, L.; Marti-Nin, T.; Ozerdem, U.; David, G.

10.1101/2022.03.08.483463 — cancer biology — Posted on 2022-04-29

102 Model building in SHELXE

Uson, I.; Sheldrick, G. M.

10.1101/2022.04.28.489939 — biophysics — Posted on 2022-04-29

103 Multiscale obstruction sensitivity in collective cell migration

Lee, Y. L.; Mathur, J.; Walter, C.; Zmuda, H.; Pathak, A.

10.1101/2022.04.28.489943 — biophysics — Posted on 2022-04-29

104 Interrogating RNA-small molecule interactions with structure probing and AI augmented-molecular simulations

Wang, Y.; Parmar, S.; Schneekloth, J. S.; Tiwary, P.

10.1101/2021.09.28.462207 — biophysics — Posted on 2022-04-29

105 Sub-sampling of cues in associative learning

Perez, O. D.; Vogel, E. H.; Narasiwodeyar, S.; Soto, F. A.

10.1101/713420 — animal behavior and cognition — Posted on 2022-04-29

106 Karyorelict ciliates use an ambiguous genetic code with context-dependent stop/sense codons

Seah, B. K. B.; Singh, A.; Swart, E.

10.1101/2022.04.12.488043 — genomics — Posted on 2022-04-29

107 Single cell profiling of functionally cured Chronic Hepatitis B patients reveals the emergence of activated innate and an altered adaptive immune response in the intra-hepatic environment

NARMADA, B. C.; KHAKPOOR, A.; SHIRGAONKAR, N.; NARAYANAN, S.; AW, P. P. K.; SINGH, M.; ONG, K. H.; OWINO, C. O.; NG, J. W. T.; YEW, H. C.; BINTE MOHAMED NASIR, N. S.; AU, V. B.; SNG, R.; KALIAPERUMAL, N.; Khine, H. H. T. W.; NG, H. X.; CHIA, S. L.; SEAH, C. X. Y.; HJ ALNAWAZ, M.; WAI, C. L. Y.; TAY, A. Y. L.; YU, W.; CONNOLLY, J. E.; PERIYASAMY, G.; LIM, S. G.; DASGUPTA, R.

10.1101/2022.04.26.489625 — genomics — Posted on 2022-04-29

108 Loss of heterochromatin at endogenous retroviruses creates competition for transcription factor binding

O'Hara, R.; Banaszynski, L. A.

10.1101/2022.04.28.489907 — genomics — Posted on 2022-04-29

109 The effect of mainland dynamics on data and parameter estimates in island biogeography

Lambert, J. W.; Santos Neves, P.; Bilderbeek, R. J. C.; Valente, L.; Etienne, R. S.

10.1101/2022.01.13.476210 — evolutionary biology — Posted on 2022-04-29

110 Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

Tixi, W.; Maldonado, M.; Chang, Y.-T.; Parveen, N.; Chiu, A.; Nelson, M.; Hart, R. G.; Wang, S.; Hsu, W. J.; Kopp, J. L.; Huising, M. O.; Dhawan, S.; Shih, H.-P.

10.1101/2022.04.27.489466 — developmental biology — Posted on 2022-04-29

111 Age of the bone marrow dictates clonality of smooth muscle-derived cells in the atherosclerotic plaque

Kabir, I.; Zhang, X.; Dave, J.; Chakraborty, R.; Qu, R.; Chandran, R. R.; Ntokou, A.; Gallardo-Vara, E.; Aryal, B.; Rotllan, N.; Garcia-Milian, R.; Hwa, J.; Klugar, Y.; Martin, K. A.; Fernandez-Hernando, C.; Greif, D. M.

10.1101/2022.01.18.476756 — cell biology — Posted on 2022-04-29

112 Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina

Babu, S.; Takeuchi, Y.; Masai, I.

10.1101/2021.11.03.467208 — cell biology — Posted on 2022-04-29

113 Signals Generated by Neutrophil Receptors for Danger Molecules Transactivate Allosterically Modulated FFA2R: Distinct response patterns are mediated by modulators recognized by different allosteric receptor sites

Lind, S. C.; Granberg, K. L.; Forsman, H.; Dahlgren, C.

10.1101/2022.04.29.489985 — cell biology — Posted on 2022-04-29

114 Evolution and antiviral activity of a human protein of retroviral origin

Frank, J. A.; Singh, M.; Cullen, H. B.; Kirou, R. A.; Benkaddour-Boumzaouad, M.; Cortes, J. L.; Garcia-Perez, J.; Coyne, C. B.; Feschotte, C.

10.1101/2020.08.23.263665 — molecular biology — Posted on 2022-04-29

115 Neryl acetate, the major component of Corsican Helichrysum Italicum essential oil, mediates its biological activities on skin barrier

LEMAIRE, G.; Olivero, M.; Rouquet, V.; Moga, A.; Pagnon, A.; Cenizo, V.; Portes, P.

10.1101/2022.04.29.490077 — molecular biology — Posted on 2022-04-29

116 Divergent transcriptional response to thermal stress among life stages could constrain coral adaptation to climate change

Ruggeri, M.; Zhang, Y.; Aglyamova, G. V.; Kenkel, C. D.

10.1101/2022.04.29.490056 — molecular biology — Posted on 2022-04-29

117 CpG enrichment as a vaccine strategy for influenza A virus

Sharp, C.; Thompson, B. H.; Nash, T. J.; Thorley, L.; Clohisey, S. M. R.; Lin, Y.-T.; Sives, S.; Wise, H.; Lee, O.; Vervelde, L.; Grey, F.; Simmonds, P.; Digard, P.; Gaunt, E. R.

10.1101/2022.04.29.490024 — microbiology — Posted on 2022-04-29

118 Core genome sequencing and genotyping of Leptospira interrogans in clinical samples by target capture sequencing

Grillova, L.; Cokelaer, T.; Mariet, J.-F.; Pipoli da Fonseca, J.; PICARDEAU, M.

10.1101/2022.04.29.490004 — microbiology — Posted on 2022-04-29

119 Few amino acid mutations in H6 influenza A virus from South American lineage increase pathogenicity in poultry

Rimondi, A.; Olivera, V.; Soria, I.; Parisi, G.; Rumbo, M.; Perez, D. R.

10.1101/2022.04.28.489980 — microbiology — Posted on 2022-04-29

120 HIV-1 Rev-RRE Functional Activity in Primary Isolates is Highly Dependent on Minimal Context-Dependent Changes in Rev

Dzhivhuho, G.; Holsey, J.; O'Farrell, H.; Rekosh, D.; Hammmarskjold, M.-L. A.; Jackson, P. E. H.

10.1101/2022.04.29.490105 — microbiology — Posted on 2022-04-29

121 Understanding transformation tolerant visual object representations in the human brain and convolutional neural networks

Xu, Y.; Vaziri-Pashkam, M.

10.1101/2020.08.11.246934 — neuroscience — Posted on 2022-04-29

122 Cortical tracking of lexical speech units in a multi-talker background is immature in school-aged children

Niesen, M.; Bourguignon, M.; Bertels, J.; Vander Ghinst, M.; Wens, V.; Goldman, S.; De Tiege, X.

10.1101/2022.04.29.490006 — neuroscience — Posted on 2022-04-29

123 MT-MAG: Accurate and interpretable machine learning for complete or partial taxonomic assignments of metagenome-assembled genomes

Li, W.; Kari, L.; Yu, Y.; Hug, L. A.

10.1101/2022.01.12.475159 — bioinformatics — Posted on 2022-04-29

124 NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data

Bahl, E.; Chatterjee, S.; Elsadany, M.; Vanrobaeys, Y.; Lin, L.-C.; Giese, K. P.; Abel, T.; Michaelson, J.

10.1101/2022.04.08.487573 — bioinformatics — Posted on 2022-04-29

125 Distinct glycerophospholipids potentiate Gsα-activated adenylyl cyclase activity

Seth, A.; Landau, M.; Shevchenko, A.; Traikov, S.; Schultz, A.; Elsabbagh, S.; Schultz, J. E.

10.1101/2022.02.23.481604 — biochemistry — Posted on 2022-04-29

126 Generalizing Bayesian phylogenetics to infer shared evolutionary events

Oaks, J. R.; Wood, P. L.; Siler, C. D.; Brown, R. M.

10.1101/2021.07.23.453597 — evolutionary biology — Posted on 2022-04-29

127 Sticky Pi, an AI-powered smart insect trap for community chronoecology

Geissmann, Q.; Abram, P. K.; Wu, D.; Haney, C. H.; Carrillo, J.

10.1101/2021.08.11.455750 — ecology — Posted on 2022-04-29

128 High genetic diversity in the pelagic deep-sea fauna of the Atacama Trench revealed by environmental DNA

Ramirez-Flandes, S.; Gonzalez, C.; Aldunate, M.; Poulain, J.; Wincker, P.; Glud, R.; Escribano, R.; Arnaud, S.; Ulloa, O.

10.1101/2022.04.14.488404 — ecology — Posted on 2022-04-29

129 ATM modulates nuclear mechanics by regulating lamin A levels

Shah, P.; McGuigan, C. W.; Cheng, S.; Vanpouille-Box, C. I.; Demaria, S.; Weiss, R. S.; Lammerding, J.

10.1101/2022.02.28.482418 — cell biology — Posted on 2022-04-29

130 An Ensemble Learning and Slice Fusion Strategy for Three-Dimensional Nuclei Instance Segmentation

Wu, L.; Chen, A.; Salama, P.; Dunn, K. W.; Delp, E. J.

10.1101/2022.04.28.489938 — cell biology — Posted on 2022-04-29

131 'Erythritol, a safe natural sweetener exhibits multi-stage anti-malarial activity by blocking Plasmodium falciparum membrane transporter 'aquaporin

Singh, S.; Kumari, J.; Kumar, V.; Behl, A.; Sah, R. K.; Garg, S.; Pati, S.; Samby, K.; Burrows, J. N.; Mohandas, N.

10.1101/2022.04.28.489976 — molecular biology — Posted on 2022-04-29

132 Molecular Determinants of Tissue Specificity of Flavivirus Nonstructural Protein 1 Interaction with Endothelial Cells

Lo, N. T.; Roodsari, S.; Tin, N. R.; Biering, S. B.; Harris, E.

10.1101/2022.04.28.489972 — microbiology — Posted on 2022-04-29

133 High fat diet changes bacterial signatures in the murine pancreas

Scheithauer, T. P. M.; David, M.; Winkelmeijer, M.; Havik, S.; Nieuwdorp, M.; Herrema, H.; van Raalte, D.

10.1101/2022.04.29.490014 — microbiology — Posted on 2022-04-29

134 Bacterial catabolic system of acetovanillone and acetosyringone useful for upgrading aromatic compounds obtained through chemical lignin depolymerization

Higuchi, Y.; Kamimura, N.; Takenami, H.; Kikuiri, Y.; Yasuta, C.; Tanatani, K.; Shobuda, T.; Otsuka, Y.; Nakamura, M.; Sonoki, T.; Masai, E.

10.1101/2022.04.28.489975 — microbiology — Posted on 2022-04-29

135 Regenerating axolotl retinas regrow diverse cell types with modulation by Notch signaling and reconnect to the brain

Yandulskaya, A. S.; Miller, M. N.; Ansaripour, R.; Carrier, R. L.; Monaghan, J. R.

10.1101/2022.04.28.489898 — neuroscience — Posted on 2022-04-29

136 Immediate myeloid depot for SARS-CoV-2 in the human lung

Magnen, M.; You, R.; Rao, A. A.; Davis, R. T.; Rodriguez, L.; Simoneau, C. R.; Hysenaj, L.; Hu, K. H.; The UCSF COMET Consortium, ; Love, C.; Woodruff, P. G.; Erle, D. J.; Hendrickson, C. M.; Calfee, C. S.; Matthay, M. A.; Roose, J. P.; Sil, A.; Ott, M.; Langelier, C. R.; Krummel, M. F.; Looney, M. R.

10.1101/2022.04.28.489942 — immunology — Posted on 2022-04-29

137 Lysosomal alterations and decreased electrophysiological activity in CLN3 disease (966 bp deletion, E295K) patient-derived cortical neurons

Chear, S.; Perry, S.; Wilson, R.; Bindoff, A.; Talbot, J.; Ware, T.; Grubman, A.; Vickers, J. C.; Pebay, A.; Ruddle, J. B.; King, A. E.; Hewitt, A. W.; Cook, A. L.

10.1101/2022.04.28.489465 — neuroscience — Posted on 2022-04-29

138 Senescence-Induced Immune Remodeling Facilitates Metastatic Adrenal Cancer in a Sex-Dimorphic Manner

Warde, K. M.; Liu, L.; Smith, L. J.; Lohman, B. K.; Stubben, C. J.; Ekiz, H. A.; Ammer, J. L.; Converso-Baran, K.; Giordano, T. J.; Hammer, G. D.; Basham, K. J.

10.1101/2022.04.29.488426 — cancer biology — Posted on 2022-04-29

139 Detergent headgroups control TolC folding in vitro

Ikujuni, A. P.; Budiardjo, S. J.; Slusky, J. S. G.

10.1101/2022.04.28.489915 — biophysics — Posted on 2022-04-29

140 TAMPA: interpretable analysis and visualization of metagenomics-based taxon abundance profiles

Sarwal, V.; Brito, J.; Mangul, S.; Koslicki, D. J.

10.1101/2022.04.28.489926 — bioinformatics — Posted on 2022-04-29

141 Modeling Transient Brain Coactivity Patterns in Latent Space with FMRI Data

Li, K.; Hu, X. P.

10.1101/2022.04.28.489899 — bioengineering — Posted on 2022-04-29

142 Polyphyly of the Niphargus stygius species group (Crustacea, Amphipoda, Niphargidae) in the Southern Limestone Alps

Stoch, F.; Salussolia, A.; Flot, J.-F.

10.1101/2022.04.28.489871 — evolutionary biology — Posted on 2022-04-29

143 Classification of electrically-evoked compound action potentials in the parkinsonian subthalamic nucleus of non-human primates

Rosing, J.; Doyle, A.; Brinda, A.; Blumenfeld, M.; Lecy, E.; Spencer, C.; Dao, J.; Krieg, J.; Wilmerding, L. K.; Sullivan, D.; Best, S.; Mohanty, B.; Wang, J.; Johnson, L. A.; Vitek, J. L.; Johnson, M. D.

10.1101/2022.04.28.489769 — neuroscience — Posted on 2022-04-29

144 C-Jun N-terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-mediated ALS and FTD

TG, S.; Chase, K. J.; Liu, F.; Lloyd, T. E.; Rossoll, W.; Zhang, K.

10.1101/2022.04.28.489917 — neuroscience — Posted on 2022-04-29

145 Genome-wide screen for enhanced noncanonical amino acid incorporation in yeast

Zackin, M. T.; Stieglitz, J. T.; Van Deventer, J. A.

10.1101/2022.04.28.489958 — synthetic biology — Posted on 2022-04-29

146 Mechanism of multimodal substrate translocation in P-glycoprotein

Gewering, T.; Waghray, D.; Parey, K.; Zapata, J.; Zhao, P.; Chen, H.; Januliene, D.; Urbatsch, I. L.; Moeller, A.; Zhang, Q.

10.1101/2022.04.28.489897 — biophysics — Posted on 2022-04-29

147 Data-driven Identification of Total RNA Expression Genes (TREGs) for Estimation of RNA Abundance in Heterogeneous Cell Types

Huuki-Myers, L. A.; Montgomery, K. D.; Kwon, S. H.; Page, S. C.; Hicks, S. C.; Maynard, K. R.; Collado-Torres, L.

10.1101/2022.04.28.489923 — bioinformatics — Posted on 2022-04-29

148 Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data

Claeys, A.; Staut, J.; Merseburger, P.; Marchal, K.; Van den Eynden, J.

10.1101/2022.04.28.489842 — bioinformatics — Posted on 2022-04-29

149 Argon plasma-modified bacterial cellulose filters for protection against respiratory pathogens

Zywicka, A.; Ciecholewska-Jusko, D.; Szymanska, M.; Drozd, R.; Sobolewski, P.; Junka, A.; Gorgieva, S.; El Fray, M.; Fijalkowski, K.

10.1101/2022.04.28.489859 — bioengineering — Posted on 2022-04-29

150 A Unifying Statistical Framework to Discover Disease Genes from GWAS

McManus, J. N.; Lovelett, R. J.; Lowengrub, D.; Christensen, S.

10.1101/2022.04.28.489887 — genomics — Posted on 2022-04-29

151 Long-term temporal trends in gastrointestinal parasite infection in wild Soay sheep

Hayward, A. D.; Behnke, J. M.; Childs, D. Z.; Corripio-Miyar, Y.; Fenton, A.; Fraser, M. D.; Kenyon, F.; McNeilly, T. N.; Pakeman, R. J.; Pedersen, A. B.; Pemberton, J. M.; Sweeny, A. R.; Wilson, K.; Pilkington, J. G.

10.1101/2022.04.28.489843 — ecology — Posted on 2022-04-29

152 Touch receptor end-organ innervation and function requires sensory expression of the transcription factor Meis2.

Desiderio, S.; Schwaller, F.; Lewin, G. R.; Carroll, P.; Marmigere, F.

10.1101/2022.04.28.489889 — developmental biology — Posted on 2022-04-29

153 A bacteriophage-based, highly efficacious, needle and adjuvant-free, mucosal COVID-19 vaccine

Zhu, J.; Jain, S.; Sha, J.; Batra, H.; Ananthaswamy, N.; Kilgore, P. B.; Hendrix, E.; Hosakote, Y. M.; Wu, X.; Olano, J. P.; Kayode, A.; Galindo, C. L.; Banga, S.; Drelich, A.; Tat, V.; Tseng, C.-T. K.; Chopra, A. K.; Rao, V. B.

10.1101/2022.04.28.489809 — microbiology — Posted on 2022-04-29

154 Sex Differences in Central Amygdala Reactivity following Psychedelic Drug Exposure

Effinger, D. P.; Quadir, S. G.; Ramage, M. C.; Cone, M. G.; Herman, M. A.

10.1101/2022.04.28.489882 — neuroscience — Posted on 2022-04-29

155 Microglial ferroptotic stress causes non-cell autonomous neuronal death

Liddell, J. R.; Hilton, J. B. W.; Kysenius, K.; Nikseresht, S.; McInnes, L. E.; Hare, D. J.; Paul, B.; Trist, B. G.; Double, K. L.; Mercer, S. W.; Ayton, S.; Roberts, B. R.; Beckman, J. S.; McLean, C. A.; White, A. R.; Donnelly, P. S.; Bush, A. I.; Crouch, P. J.

10.1101/2022.04.28.489869 — neuroscience — Posted on 2022-04-29

156 A model of the mouse cortex with attractor dynamics explains the structure and emergence of rsfMRI co-activation patterns

Fasoli, D.; Coletta, L.; Gutierrez-Barragan, D.; Gozzi, A.; Panzeri, S.

10.1101/2022.04.28.489908 — neuroscience — Posted on 2022-04-29

Herrmann, B.; Maess, B.; Johnsrude, I. S.

10.1101/2022.04.28.489911 — neuroscience — Posted on 2022-04-29

158 Smoke exposed roots causes reduced whole-plant vascular sectoriality.

Benoit, M.; Waller, S.; Wilder, S. L.; Schueller, M. J.; Ferrieri, R. A.

10.1101/2022.04.28.489912 — physiology — Posted on 2022-04-29

159 Differentiated dynamic response in C. elegans chemosensory cilia

Bruggeman, C. W.; Haasnoot, G. H.; Danne, N.; van Krugten, J.; Peterman, E. J. G.

10.1101/2022.04.28.489874 — biophysics — Posted on 2022-04-29

160 Systematic analysis of alternative splicing in time course data using Spycone

Lio, C. T.; Louadi, Z.; Fenn, A.; Baumbach, J.; Kacprowski, T.; List, M.; Tsoy, O.

10.1101/2022.04.28.489857 — bioinformatics — Posted on 2022-04-29

161 A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink between Three Residues C22, C44, and K61 Is a Redox Switch of the SARS-CoV-2 Main Protease

Yang, K. S.; Kuo, S.-T. A.; Blankenship, L. R.; Sheng, Y. J.; Sankaran, B.; Li, P.; Fierkee, C. A.; Russell, D. H.; Yan, X.; Xu, S.; Liu, W. R.

10.1101/2022.04.29.490044 — biochemistry — Posted on 2022-04-29

162 Complete sequences of six Major Histocompatibility Complex haplotypes, including all the major MHC class II structures

Houwaart, T.; Scholz, S.; Pollock, N.; Palmer, W. H.; Kichula, K.; Strelow, D.; Le, D. B.; Belick, D.; Lautwein, T.; Wachtmeister, T.; Henrich, B.; Köhrer, K.; Parham, P.; Guethlein, L. A.; Norman, P.; Dilthey, A. T.

10.1101/2022.04.28.489875 — genomics — Posted on 2022-04-29

163 Developmental changes of opsin gene expression in ray-finned fishes (Actinopterygii)

Lupse, N.; Kłodawska, M.; Truhlárova, V.; Kosatko, P.; Kaspar, V.; Bitja Nyom, A. R.; Musilova, Z.

10.1101/2022.04.28.489877 — evolutionary biology — Posted on 2022-04-29

164 California's forest carbon offsets buffer pool is severely undercapitalized

Badgley, G.; Chay, F.; Chegwidden, O. S.; Hamman, J. J.; Freeman, J.; Cullenward, D.

10.1101/2022.04.27.488938 — ecology — Posted on 2022-04-29

165 Plasma membrane topography governs the three-dimensional dynamic localization of IgM B cell receptor clusters

Saltukoglu, D.; Oezdemir, B.; Holtmannspoetter, M.; Reski, R.; Piehler, J.; Kurre, R.; Reth, M.

10.1101/2022.04.29.489661 — cell biology — Posted on 2022-04-29

166 Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte Dedifferentiation

Duke-Cohan, J. S.; Akitsu, A.; Mallis, R. J.; Messier, C. M.; Lizotte, P. H.; Hwang, W.; Lang, M. J.; Reinherz, E. L.

10.1101/2022.04.28.489872 — immunology — Posted on 2022-04-29

167 Deficiency in pericyte remodeling as a basis for impaired capillary flow and structure during brain aging

Berthiaume, A.-A.; Schmid, F.; Stamenkovic, S.; Santos, V.; Nielson, C.; Weber, B.; Majesky, M.; Shih, A.

10.1101/2022.04.28.489881 — neuroscience — Posted on 2022-04-29

168 Face Familiarity Revealed by Fixational Eye Movements and Fixation-Related Potentials in Free Viewing

Kadosh, O.; Bonneh, Y. S.

10.1101/2022.04.28.489860 — neuroscience — Posted on 2022-04-29

169 High resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex

Haenelt, D.; Trampel, R.; Nasr, S.; Polimeni, J.; Tootell, R. B.; Sereno, M. I.; Pine, K.; Edwards, L. J.; Helbling, S.; Weiskopf, N.

10.1101/2022.04.28.489865 — neuroscience — Posted on 2022-04-29

170 Sugar transporter Slc37a2 regulates bone metabolism via a dynamic tubular lysosomal network in osteoclasts

Ng, P. Y.; Ribet, A.; Guo, Q.; Mullin, B.; Tan, J.; Landao-Bassonga, E.; Stephens, S.; Chen, K.; Abudulai, L.; Bollen, M.; Nguyen, E.; Kular, J.; Papadimitriou, J.; Soe, K.; Teasdale, R.; Xu, J.; Parton, R. G.; Takayanagi, H.; Pavlos, N.

10.1101/2022.04.28.489831 — cell biology — Posted on 2022-04-29

171 An Ensemble Learning and Slice Fusion Strategy for Three-Dimensional Nuclei Instance Segmentation

Wu, L.; Chen, A.; Salama, P.; Dunn, K. W.; Delp, E. J.

10.1101/2022.04.28.489938 — cell biology — Posted on 2022-04-29

172 Molecular architecture of the autoinhibited kinesin-1 lambda particle

Weijman, J. F.; Kadapalakere, S. Y.; Surridge, K. J.; Cross, J. A.; Borucu, U.; Mantell, J.; Woolfson, D. N.; Schaffitzel, C.; Dodding, M. P.

10.1101/2022.04.28.489841 — cell biology — Posted on 2022-04-29

173 Content-aware image restoration improves spatiotemporal resolution in luminescence microscopy.

Boothe, T.; Ivankovic, M.; Grohme, M. A.; Rink, J. C.

10.1101/2022.04.29.490012 — cell biology — Posted on 2022-04-29

174 Perceptual restoration fails to recover unconscious processing for smooth eye movements after occipital stroke

Kwon, S.; Fahrenthold, B. K.; Cavanaugh, M. R.; Huxlin, K. R.; Mitchell, J. F.

10.1101/2021.02.16.431524 — neuroscience — Posted on 2022-04-29

175 Replication Fork Uncoupling Causes Nascent Strand Degradation and Fork Reversal

Kavlashvili, T.; Dewar, J. M.

10.1101/2021.10.13.464136 — biochemistry — Posted on 2022-04-29

176 Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms

Van Ravenstein, S. X.; Mehta, K. P.; Kavlashvili, T.; Byl, J. A.; Zhao, R.; Osheroff, N.; Cortez, D.; Dewar, J. M.

10.1101/2021.10.12.464107 — biochemistry — Posted on 2022-04-29

177 Intragenomic rearrangements of SARS-CoV-2, other betacoronaviruses, and alphacoronaviruses

Patarca, R.; Haseltine, W. A.

10.1101/2022.03.07.483258 — molecular biology — Posted on 2022-04-29

178 ABA-induced SA accumulation causes higher susceptibility in B. juncea as compared to tolerant genotypes against A. brassicae

Dixit, S.; Grover, A.; Pushkar, S.; Singh, S.

10.1101/2022.04.28.489833 — plant biology — Posted on 2022-04-29

179 All-trans retinoic acid enhances the antitumor effects of fimaporfin-based photodynamic therapy

Wong, J. J. W.; Lorenz, S.; Selbo, P. K.

10.1101/2022.04.28.487643 — cancer biology — Posted on 2022-04-29

180 Human cerebral tissue growth is a critical process

Kiselev, E. I.; Pflug, F.; von Haeseler, A.

10.1101/2022.04.28.489779 — biophysics — Posted on 2022-04-29

181 The Repeating, Modular Architecture of the HtrA Proteases

Merski, M.; Macedo-Ribeiro, S.; Wieczorek, R. M.; Gorna, M. W.

10.1101/2022.04.28.489847 — bioinformatics — Posted on 2022-04-29

182 A magnetic pulse does not affect free-flight navigation behaviour of a medium-distance songbird migrant in spring

Karwinkel, T.; Winklhofer, M.; Janner, L. E.; Brust, V.; Hüppop, O.; Bairlein, F.; Schmaljohann, H.

10.1101/2022.04.28.489840 — animal behavior and cognition — Posted on 2022-04-29

183 Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery

Siegenfeld, A. P.; Roseman, S. A.; Roh, H.; Lue, N. Z.; Wagen, C. C.; Zhou, E.; Johnstone, S. E.; Aryee, M. J.; Liau, B. B.

10.1101/2022.04.28.489608 — genomics — Posted on 2022-04-29

184 Multi-scale phase separation by explosive percolation with single chromatin loop resolution

Sengupta, K.; Denkiewicz, M.; Chilinski, M.; Szczepinska, T.; Mollah, A. F.; Korsak, S.; D'Souza, R.; Ruan, Y.; Plewczynski, D.

10.1101/2022.04.28.489670 — genomics — Posted on 2022-04-29

185 Analysis of allelic cross-reactivity of monoclonal IgG antibodies by a multiplexed reverse FluoroSpot assay

Hoffmann-Veltung, H.; Anabire, N. G.; Ofori, M. F.; Janhmatz, P.; Ahlborg, N.; Hviid, L.; Quintana, M. d. P.

10.1101/2022.04.28.489862 — immunology — Posted on 2022-04-29

186 Spike-dependent dynamic partitioning of the Locus coeruleus network through noradrenergic volume release in a simulation of nucleus core

Baral, S.; Hosseini, H.; More, K.; Fabrin, T. M. C.; Braun, J.; Prigge, M.

10.1101/2022.02.13.480256 — neuroscience — Posted on 2022-04-29

187 Distributed and gradual microstructure changes track the emergence of behavioural benefit from memory reactivation

Rakowska, M.; Lazari, A.; Cercignani, M.; Bagrowska, P.; Johansen-Berg, H.; Lewis, P. A.

10.1101/2022.04.28.489844 — neuroscience — Posted on 2022-04-29

188 Sweet taste receptor cells may participate in mucosal immune surveillance

Qin, Y.; Zheng, X.; Tian, S.; Margolskee, R. F.; Sukumaran, S.

10.1101/2022.04.28.489835 — neuroscience — Posted on 2022-04-29

189 Opposite polarity programs regulate asymmetric subsidiary cell divisions in grasses

Zhang, D.; Abrash, E. B.; Nunes, T. D.; Hidalgo, I.; Gil, M. X. A.; Jesenofsky, B.; Lindner, H.; Bergmann, D. C.; Raissig, M. T.

10.1101/2022.04.24.489281 — plant biology — Posted on 2022-04-29

190 Chemical screen of Arabidopsis zygote and proteomics in tobacco BY-2 cells identify general plant cell division inhibitors

Kimata, Y.; Yamada, M.; Murata, T.; Kuwata, K.; Sato, A.; Suzuki, T.; Kurihara, D.; Hasebe, M.; Higashiyama, T.; Ueda, M.

10.1101/2022.04.28.489799 — plant biology — Posted on 2022-04-29

191 Improved antiproliferative activity of doxorubicin-loaded calcium phosphate nanoparticles against melanoma cells

Lima, I. B.; Alvarenga, B. M.; Totaro, P. I. S. d.; Boratto, F.; Leite, E. A.; Guimaraes, P. P. G.

10.1101/2022.04.21.489118 — cancer biology — Posted on 2022-04-29

192 Cooperative protein allosteric transition mediated by a fluctuating transmission network

Post, M.; Lickert, B.; Diez, G.; Wolf, S.; Stock, G.

10.1101/2021.11.17.468836 — biophysics — Posted on 2022-04-29

193 An objective criterion to evaluate sequence-similarity networks helps in dividing the protein family sequence space

Hornung, B.; Terrapon, N.

10.1101/2022.04.19.488343 — bioinformatics — Posted on 2022-04-29

194 Structural insights into p300 regulation and acetylation-dependent genome organisation

Ibrahim, Z.; Wang, T.; Destaing, O.; Salvi, N.; Hoghoughi, N.; Chabert, C.; Rusu, A. D.; Gao, J.; Feletto, L.; Reynoird, N.; Schalch, T.; Zhao, Y.; Blackledge, M.; Khochbin, S.; Panne, D.

10.1101/2022.03.14.484228 — biochemistry — Posted on 2022-04-29

195 High quality genomes corroborate 29 chromosomes of the haploid Hyles (Lepidoptera: Sphingidae) karyotype

Hundsdoerfer, A. K.; Schell, T.; Patzold, F.; Yoshido, A.; Marec, F.; Daneck, H.; Winkler, S.; Greve, C.; Hiller, M.; Pippel, M.

10.1101/2022.04.08.487644 — genomics — Posted on 2022-04-29

196 ODGI: understanding pangenome graphs

Guarracino, A.; Heumos, S.; Nahnsen, S.; Prins, P.; Garrison, E.

10.1101/2021.11.10.467921 — genomics — Posted on 2022-04-29

197 Mapping the planet's critical natural assets

Chaplin-Kramer, R.; Neugarten, R.; Sharp, R. P.; Collins, P. M.; Polasky, S.; Hole, D.; Schuster, R.; Strimas-Mackey, M.; Mulligan, M.; Brandon, C.; Diaz, S.; Fluet-Chouinard, E.; Gorenflo, L.; Johnson, J. A.; Kennedy, C. M.; Pascual, U.; Keys, P. W.; Longley-Wood, K.; McIntyre, P. B.; Noon, M.; Reidy Liermann, C.; Roehrdanz, P.; Schmidt-Traub, G.; Shaw, M. R.; Spalding, M.; Turner, W. R.; van Soesbergen, A.; Watson, R.

10.1101/2020.11.08.361014 — ecology — Posted on 2022-04-29

198 A multi-continental analysis of the responses of freshwater food webs to climate and land use change

Barbosa, G. P.; Siqueira, T.

10.1101/2022.04.18.488700 — ecology — Posted on 2022-04-29

199 The effect of COVID-19 mRNA vaccine on respiratory system: human lung carcinoma cells by means of Raman spectroscopy and imaging.

Abramczyk, H.; Surmacki, J. M.

10.1101/2022.01.24.477476 — cell biology — Posted on 2022-04-29

200 Activation of endoplasmic reticulum stress via clustering of inner nuclear membrane proteins

Vidak, S.; Serebryannyy, L. A.; Pegoraro, G.; Misteli, T.

10.1101/2021.09.14.460295 — cell biology — Posted on 2022-04-29

201 The antibiotic phazolicin displays a dual mode of uptake in Gram-negative bacteria

Travin, D. Y.; Vigouroux, A.; Inaba-Inoue, S.; Qu, F.; Jouan, R.; Lachat, J.; Sutormin, D.; Dubiley, S.; Beis, K.; MORERA, S.; Severinov, K. V.; Mergaert, P.

10.1101/2022.04.27.489825 — molecular biology — Posted on 2022-04-29

202 Microbiota-instructed regulatory T cell differentiation is mediated by a distinct RORγt+ antigen presenting cell subset

Kedmi, R.; Najar, T.; Mesa, K. R.; Grayson, A.; Kroehling, L.; Hao, Y.; Hao, S.; Pokrovskii, M.; Xu, M.; Talbot, J.; Wang, J.; Germino, J.; Lareau, C. A.; Satpathy, A. T.; Anderson, M. S.; Laufer, T. M.; Aifantis, I.; Bartleson, J. M.; Allen, P. M.; Paidassi, H.; Gardner, J. M.; Stoeckius, M.; Littman, D. R.

10.1101/2021.11.19.469318 — immunology — Posted on 2022-04-29

203 Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX

Cheng, M. I.; Riggan, L.; Li, J. H.; Tafti, R. Y.; Chin, S.; Ma, F.; Pellegrini, M.; Hrncir, H.; Arnold, A. P.; O'Sullivan, T. E.; Su, M. A.

10.1101/2022.04.21.489076 — immunology — Posted on 2022-04-29

204 Hydrodynamic and Polyelectrolyte Properties of Actin Filaments: Theory and Experiments

Alva Sevilla, E.; George, A.; Brancaleon, L.; Marucho, M.

10.1101/2022.01.11.475973 — neuroscience — Posted on 2022-04-29

205 Normative Decision Rules in Changing Environments

Barendregt, N. W.; Gold, J. I.; Josic, K.; Kilpatrick, Z. P.

10.1101/2022.04.27.489722 — neuroscience — Posted on 2022-04-29

206 Global brain health modulates the impact of lesion damage on post-stroke sensorimotor outcomes

Liew, S.-L.; Schweighofer, N.; Cole, J. H.; Zavaliangos-Petropulu, A.; Lo, B. P.; Han, L. K.; Hahn, T.; Schmaal, L.; Donnelly, M. R.; Jeong, J. N.; Wang, Z.; Abdullah, A.; Kim, J. H.; Hutton, A.; Barisano, G.; Borich, M. R.; Boyd, L. A.; Brodtmann, A.; Buetefisch, C. M.; Byblow, W. D.; Cassidy, J. M.; Charalambous, C. C.; Ciullo, V.; Conforto, A. B.; Dacosta-Aguayo, R.; DiCarlo, J. A.; Domin, M.; Dula, A. N.; Egorova-Brumley, N.; Feng, W.; Geranmayeh, F.; Gregory, C. M.; Hanlon, C. A.; Holguin, J. A.; Hordacre, B.; Jahanshad, N.; Kautz, S. A.; Khlif, M. S.; Kim, H.; Kuceyeski, A.; Lin, D. J.;

10.1101/2022.04.27.489791 — neuroscience — Posted on 2022-04-29

207 A translational MRI approach to validate acute axonal damage detection in multiple sclerosis

Toschi, N.; Cerdan Cerda, A.; Treaba, C. A.; Barletta, V.; Herranz Muelas, E.; Mehndiratta, A.; Canals, S.; Mainero, C.; De Santis, S.

10.1101/2022.04.27.489694 — neuroscience — Posted on 2022-04-29

208 Nonquantal Transmission at the Vestibular Hair Cell-Calyx Synapse: KLV currents Modulate Fast Electrical and Slow K+ potentials in the Synaptic Cleft

Govindaraju, A. C.; Quraishi, I. H.; Lysakowski, A.; Eatock, R. A.; Raphael, R. M.

10.1101/2021.11.18.469197 — neuroscience — Posted on 2022-04-29

Fareri, D. S.; Hackett, K.; Tepfer, L. J.; Kelly, V. A.; Henninger, N.; Reeck, C.; Giovannetti, T.; Smith, D. V.

10.1101/2021.07.29.454071 — neuroscience — Posted on 2022-04-29

210 The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

Kim, D.-H.; Jin, I.-B.; Kim, N.-H.; Jeon, Y.-J.; Choi, B.-R.; Gallagher, M.; Han, J.-S.

10.1101/2022.04.27.489815 — neuroscience — Posted on 2022-04-29

211 Sleep spindles in primates: modelling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits

Yazdanbakhsh, A.; Barbas, H.; Zikopoulos, B.

10.1101/2022.04.27.489802 — neuroscience — Posted on 2022-04-29

212 Volitional generation of reproducible energy-efficient temporal patterns

Ning, Y.; Wan, G.; Liu, T.; Zhang, S.

10.1101/2022.04.27.489830 — neuroscience — Posted on 2022-04-29

213 Efficient coding of natural scenes improves neural system identification

Qiu, Y.; Klindt, D. A.; Szatko, K. P.; Gonschorek, D.; Hoefling, L.; Schubert, T.; Busse, L.; Bethge, M.; Euler, T.

10.1101/2022.01.10.475663 — neuroscience — Posted on 2022-04-29

214 Frontal Cortex Gates Distractor Stimulus Encoding in Sensory Cortex

Zhang, Z.; Zagha, E.

10.1101/2022.03.31.486430 — neuroscience — Posted on 2022-04-29

215 Towards a machine-learning assisted diagnosis of psychiatric disorders and their operationalization in preclinical research: evidence from studies on addiction-like behaviour in individual rats

Jadhav, K.; Boury-Jamot, B.; Deroche-Gamonet, V.; Belin, D.; Boutrel, B.

10.1101/2021.10.11.463926 — neuroscience — Posted on 2022-04-29

216 K2P channel TWK-40 Regulates a Rhythmic Behavior in C. elegans

Yue, Z.; Zhang, Y.; Yu, B.; Xu, Y.; Chen, L.; Li, Y.; Chitturi, J.; Meng, J.; Hung, W.; Mouridi, S. E.; Boulin, T.; Zhang, C.; Zhen, M.; Gao, S.

10.1101/2022.04.09.487752 — neuroscience — Posted on 2022-04-29

217 Hindbrain catecholaminergic inputs to the paraventricular thalamus scale feeding and metabolic efficiency in stress-related contexts

Dumont, C.; Li, G.; Castel, J.; Luquet, S.; Gangarossa, G.

10.1101/2022.02.03.478953 — neuroscience — Posted on 2022-04-29

218 Older circuits get richer: neurogenesis timeline shapes hubness and neurogenetic profiles of the adult human brain

diez, I.; Moreno, F. G.; Sainz, N. C.; Stramaglia, S.; Reyes, A. N.; D'Amato, M.; Cortes, J. M.; bonifazi, p.

10.1101/2022.04.01.486541 — neuroscience — Posted on 2022-04-29

219 Neurodevelopmental clustering of gene expression identifies lipid metabolism genes associated with neuroprotection and neurodegeneration.

Kohane, A. A.; Wood, T. R.

10.1101/2021.09.02.458277 — neuroscience — Posted on 2022-04-29

220 The arthropod associates of 155 North American cynipid oak galls

Ward, A. K. G.; Busbee, R. W.; Chen, R. A.; Davis, C. K.; Driscoe, A. L.; Egan, S. P.; Goldberg, B. A.; Hood, G. R.; Jones, D.; Kranz, A. J.; Meadley-Dunphy, S. A.; Milks, A. K.; Ott, J. R.; Prior, K. M.; Sheikh, S. I.; Shzu, S.-A.; Weinersmith, K. L.; Zhang, L.; Zhang, Y. M.; Forbes, A. A.

10.1101/2022.04.26.489445 — zoology — Posted on 2022-04-29

221 Influencing factors of telephone-cardiopulmonary resuscitation in China: a qualitative exploration based on managerial perspectives

Zhu, X.; Gui, L.; Chen, Y.; Lin, Y.

10.1101/775874 — systems biology — Posted on 2022-04-29

222 Scientific publications and COVID-19 "research pivots" during the pandemic: An initial bibliometric analysis

Shapira, P.

10.1101/2020.12.06.413682 — scientific communication and education — Posted on 2022-04-29

223 HOXB7 induces STAT3-mediated transformation and lung metastasis in an immortalized mammary gland NMuMG cells

Azuma, K.; Sakamoto, M.; Nakayama, J.; Katayama, S.; Matsui, A.; Goshima, N.; Watanabe, S.; Semba, K.

10.1101/2021.05.16.444388 — cancer biology — Posted on 2022-04-29

224 Focus-ISM for Sharp and Gentle Super-Resolved Microscopy

Tortarolo, G.; Zunino, A.; Fersini, F.; Castello, M.; Piazza, S.; Sheppard, C. J. R.; Bianchini, P.; Diaspro, A.; Koho, S.; Vicidomini, G.

10.1101/2022.04.28.489892 — biophysics — Posted on 2022-04-29

225 Topological action potentials in engineered tissues

Ori, H.; Duque Ramirez, M.; Hayward, R. F.; Tian, H.; Ortiz, G.; Cohen, A. E.

10.1101/2022.03.16.484369 — biophysics — Posted on 2022-04-29

226 ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA

Carcamo, C. C.; Poyton, M. F.; Ranjan, A.; Park, G.; Louder, R. K.; Dzu, T.; Wu, C.; Ha, T.

10.1101/2022.01.24.477290 — biophysics — Posted on 2022-04-29

227 Dynamic interplay between a TonB dependent heme transporter and a TonB protein in a membrane environment

Somboon, K.; Melling, O.; Lejeune, M.; M.S. Pinheiro, G.; Paquelin, A.; Bardiaux, B.; Nilges, M.; Delepelaire, P.; Khalid, S.; Izadi-Pruneyre, N.

10.1101/2021.04.21.440789 — biophysics — Posted on 2022-04-29

228 TopoGAN: Unsupervised manifold alignment of single-cell data

Singh, A.; Reinders, M.; Mahfouz, A.; Abdelaal, T.

10.1101/2022.04.27.489829 — bioinformatics — Posted on 2022-04-29

229 MIRA: Joint regulatory modeling of multimodal expression and chromatin accessibility in single cells

Lynch, A. W.; Theodoris, C. V.; Long, H.; Brown, M.; Liu, X. S.; Meyer, C. A.

10.1101/2021.12.06.471401 — bioinformatics — Posted on 2022-04-29

230 Identifying Protein Features and Pathways Responsible for Toxicity using Machine learning, CANDO, and Tox21 datasets: Implications for Predictive Toxicology

Moukheiber, L.; Mangione, W.; Moukheiber, M.; Maleki, S.; Falls, Z.; Gao, M.; Samudrala, R.

10.1101/2021.12.13.472455 — bioinformatics — Posted on 2022-04-29

231 A family of unusual immunoglobulin superfamily genes in an invertebrate histocompatibility complex

Huene, A. L.; Sanders, S. M.; Ma, Z.; Nguyen, A.-D.; Koren, S.; Michaca, M. H.; Mullikin, J. C.; Phillippy, A. M.; Schnitzler, C.; Baxevanis, A. D.; Nicotra, M. L.

10.1101/2022.03.04.482883 — genomics — Posted on 2022-04-29

232 Predicting mechanisms of action at genetic loci associated with discordant effects on type 2 diabetes and abdominal fat accumulation

Aberra, Y. T.; Ma, L.; Bjorkegren, J.; Civelek, M.

10.1101/2022.04.27.489778 — genomics — Posted on 2022-04-29

233 Leverage drug perturbation to reveal genetic regulators of hepatic gene expression in African Americans

Zhong, Y.; De, T.; Alarcon, C.; Avitia, J.; Perera, M.

10.1101/2022.04.27.489765 — genomics — Posted on 2022-04-29

234 A role for worm cutl-24 in background- and parent-of-origin-dependent ER stress resistance

Wang, W.; Flury, A.; Rodriguez, A. T.; Garrison, J.; Brem, R. B.

10.1101/2021.07.01.450736 — genetics — Posted on 2022-04-29

235 Temperature-dependent gene regulatory divergence underlies local adaptation with gene flow in the Atlantic silverside

Jacobs, A.; Velotta, J. P.; Tigano, A.; Wilder, A. P.; Baumann, H.; Therkildsen, N. O.

10.1101/2022.04.27.489786 — evolutionary biology — Posted on 2022-04-29

236 Drift as a driver of language change: An artificial language experiment

Ventura, R.; Plotkin, J. B.; Roberts, G.

10.1101/2021.03.26.437270 — evolutionary biology — Posted on 2022-04-29

237 randtip, a generalized framework to expand incomplete phylogenies using non-molecular phylogenetic information

Ramos-Gutierrez, I.; Lima, H.; Molina-Venegas, R.

10.1101/2022.01.04.474924 — evolutionary biology — Posted on 2022-04-29

238 Floral humidity as a signal--not a cue--in a nocturnal pollination system

Dahake, A.; Jain, P.; Vogt, C.; Kandalaft, W.; Stroock, A.; Raguso, R. A.

10.1101/2022.04.27.489805 — ecology — Posted on 2022-04-29

239 Quantitative environmental DNA metabarcoding reflects quantitative capture data of fish community obtained by electrical shocker

Tsuji, S.; Inui, R.; Nakao, R.; Miyazono, S.; Saito, M.; Kono, T.; Akamatsu, Y.

10.1101/2022.04.27.489619 — ecology — Posted on 2022-04-29

240 Genetic diversity loss in the Anthropocene

Exposito-Alonso, M.; Booker, T. A.; Czech, L.; Fukami, T.; Gillespie, L.; Hateley, S.; Kyriazis, C. C.; Lang, P.; Leventhal, L.; Nogues-Bravo, D.; Pagowski, V.; Ruffley, M.; Spence, J. P.; Toro Arana, S.; Weiss, C.; Zess, E.

10.1101/2021.10.13.464000 — ecology — Posted on 2022-04-29

241 Resource competition drives an invasion-replacement event among shrew species on an island

Browett, S. S.; Synnott, R.; O'Meara, D.; Antwis, R. E.; Browett, S. S.; Bown, K.; Wangensteen, O.; Dawson, D. A.; Searle, J. B.; Yearsley, J. M.; McDevitt, A.

10.1101/2022.04.27.489660 — ecology — Posted on 2022-04-29

242 Data-driven multiscale model of macaque auditory thalamocortical circuits reproduces in vivo dynamics

Dura-Bernal, S.; Griffith, E. Y.; Barczak, A.; O'Connell, M. N.; McGinnis, T.; Schroeder, C. E.; Lytton, W. W.; Lakatos, P.; Neymotin, S. A.

10.1101/2022.02.03.479036 — neuroscience — Posted on 2022-04-29

243 Quality Control Framework of TCM Preparations based on Multi-type Fingerprints using a Source Proportion Estimation Model

Zha, Y.; Yao, Q.; Zhao, D.; Zhu, X.; Bai, H.; Ning, K.

10.1101/2022.04.27.489828 — pharmacology and toxicology — Posted on 2022-04-29

244 Measuring competitive exclusion in non-small cell lung cancer

Farrokhian, N.; Maltas, J.; Dinh, M.; Durmaz, A.; Ellsworth, P.; Hitomi, M.; McClure, E.; Marusyk, A.; Kaznatcheev, A.; Scott, J. G.

10.1101/2020.09.18.303966 — cancer biology — Posted on 2022-04-29

245 Using generalized additive models to analyze biomedical non-linear longitudinal data

Mundo, A. I.; Tipton, J. R.; Muldoon, T. J.

10.1101/2021.06.10.447970 — cancer biology — Posted on 2022-04-29

246 Perfusion Quantification in the Human Brain Using DSC MRI - Simulations and Validations at 3T

Schulman, J. B.; Sayin, E. S.; Manalac, A.; Poublanc, J.; Sobczyk, O.; Duffin, J.; Fisher, J. A.; Mikulis, D. J.; Uludag, K.

10.1101/2022.04.27.489686 — biophysics — Posted on 2022-04-29

247 High transposase abundance in the deep ocean is linked to a particle-associated lifestyle

Zhong, J.; Kyrysyuk, O.; del Rosario Herhandez, T.; Tully, B. J.; Anderson, R. E.

10.1101/2022.04.27.489810 — bioinformatics — Posted on 2022-04-29

248 FASTAptameR 2.0: A Web Tool for Combinatorial Sequence Selections

Kramer, S. T.; Gruenke, P. R.; Alam, K. K.; Xu, D.; Burke, D. H.

10.1101/2022.04.27.489774 — bioinformatics — Posted on 2022-04-29

249 UniTVelo: temporally unified RNA velocity reinforces single-cell trajectory inference

Gao, M.; Qiao, C.; Huang, Y.

10.1101/2022.04.27.489808 — bioinformatics — Posted on 2022-04-29

250 Deep learning from phylogenies to uncover the epidemiological dynamics of outbreaks

Voznica, J.; Zhukova, A.; Boskova, V.; Saulnier, E.; Lemoine, F.; Moslonka-Lefebvre, M.; Gascuel, O.

10.1101/2021.03.11.435006 — bioinformatics — Posted on 2022-04-29

251 RTEL1 and MCM10 overcome topological stress during vertebrate replication termination

Campos, L. V.; Greer, B. H.; Heintzman, D. R.; Kavlashvili, T.; McDonald, W. H.; Rose, K. L.; Eichman, B. F.; Dewar, J. M.

10.1101/2022.01.27.478093 — biochemistry — Posted on 2022-04-29

252 A weighted constraint satisfaction approach to human goal-directed decision making

Li, Y.; McClelland, J. L.

10.1101/2021.10.13.464177 — animal behavior and cognition — Posted on 2022-04-29

253 Low mutation load in a supergene underpinning alternative male mating strategies in ruff

Andersson, L.; Hill, J.; Enbody, E.; Bi, H.; Lamichhaney, S.; Schwochow, D.; Younis, S.; Widemo, F.

10.1101/2022.04.27.489720 — evolutionary biology — Posted on 2022-04-29

254 Stem cell heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish

Frantz, W. T.; Iyengar, S.; Neiswender, J.; Cousineau, A.; Maehr, R.; Ceol, C. J.

10.1101/2022.04.27.489712 — cell biology — Posted on 2022-04-29

255 Purification of age-distinct insulin secretory granules through antigen restriction

Neukam, M.; Sala, P.; Brunner, A.-D.; Ganss, K.; Palladini, A.; Grzybek, M.; Vasiljevic, J.; Broichhagen, J.; Coskun, U.; Johnsson, K.; Kurth, T.; Mann, M.; Solimena, M.

10.1101/2020.06.03.103770 — cell biology — Posted on 2022-04-29

256 Evolution of the quorum sensing systems in Pseudomonas aeruginosa can involve both loss of regulon function and network modulation

Jayakumar, P.; Figueiredo, A.; Kümmerli, R.

10.1101/2022.04.27.489656 — microbiology — Posted on 2022-04-29

257 Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain

Fayad, S. L.; Ourties, G.; Le Gac, B.; Jouffre, B.; Lamoine, S.; Fruquiere, A.; Laffray, S.; Gasmi, L.; Cauli, B.; Mallet, C.; Bourinet, E.; Bessaih, T.; Lambert, R. C.; Leresche, N.

10.1101/2022.04.27.489708 — neuroscience — Posted on 2022-04-29

258 Phorbolester-activated Munc13-1 and ubMunc13-2 exert opposing effects on dense-core vesicle secretion

Houy, S.; Martins, J. S.; Lipstein, N.; Sorensen, J. B.

10.1101/2022.04.27.489716 — neuroscience — Posted on 2022-04-29

259 CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue

Woelfle, S.; Deshpande, D.; Feldengut, S.; Roselli, F.; Deisseroth, K.; Michaelis, J.; Böckers, T.; Schoen, M.

10.1101/2022.04.27.489700 — neuroscience — Posted on 2022-04-29

260 Theory for weakly polydisperse cytoskeleton filaments

Warshavsky, V.; Marucho, M.

10.1101/2022.01.12.476073 — neuroscience — Posted on 2022-04-29

261 Powdery mildew effectors AVRA1 and BEC1016 target the ER J-domain protein HvERdj3B required for immunity in barley

Li, Z.; Velasquez-Zapata, V.; Elmore, J. M.; Li, X.; Xie, W.; Banerjee, S.; Jorgensen, H. J. L.; Pedersen, C.; Wise, R. P.; Thordal-Christensen, H.

10.1101/2022.04.27.489729 — plant biology — Posted on 2022-04-29

262 Single cell profiling of functionally cured Chronic Hepatitis B patients reveals the emergence of activated innate and an altered adaptive immune response in the intra- hepatic envrionment

NARMADA, B. C.; Khakpoor, A.; SHIRGAONKAR, N.; NARAYANAN, S.; AW, P. P. K.; SINGH, M.; ONG, K. H.; OWINO, C. O.; NG, J. W. T.; YEW, H. C.; BINTE MOHAMED NASIR, N. S.; AU, V. B.; SNG, R.; KALIAPERUMAL, N.; Khine, H. H. T. W.; NG, H. X.; CHIA, S. L.; SEAH, C. X. Y.; HJ ALNAWAZ, M.; WAI, C. L. Y.; TAY, A. Y. L.; YU, W.; CONNOLLY, J. E.; PERIYASAMY, G.; LIM, S. G.; DASGUPTA, R.

10.1101/2022.04.26.489625 — genomics — Posted on 2022-04-29

263 ZW sex-chromosome evolution and contagious parthenogenesis in Artemia brine shrimp

Elkrewi, M.; Khauratovich, U.; Toups, M. A.; Bett, V. K.; Mrnjavac, A.; Macon, A.; Fraïsse, C.; Sax, L.; Huylmans, A. K.; Hontoria, F.; Vicoso, B.

10.1101/2022.04.27.489735 — evolutionary biology — Posted on 2022-04-29

264 Environmental DNA from archived leaves reveals widespread temporal turnover and biotic homogenization in forest arthropod communities

Krehenwinkel, H.; Weber, S.; Broekmann, R.; Melcher, A.; Wolf, R.; Hochkirch, A.; Kennedy, S. R.; Koschorrek, J.; Künzel, S.; Müller, C.; Reztlaff, R.; Teubner, D.; Schanzer, S.; Klein, R.; Paulus, M.; Udelhoven, T.; Veith, M.

10.1101/2022.04.27.489699 — ecology — Posted on 2022-04-29

265 Caveolae couple mechanical stress to integrin recycling and activation

Lolo, F.-N.; Pavon, D. M.; Grande, A.; Elosegui Artola, A.; Segatori, V. I.; Sanchez, S.; Trepat, X.; Pere Roca-Cusachs, P.; Angel del Pozo, M.

10.1101/2022.04.27.489710 — cell biology — Posted on 2022-04-29

266 CaV3.1 T-type calcium channels regulate spatial memory processing in the dorsal subiculum

Joksimovic, S. M.; Ghodsi, S. M.; Heinsbroek, J.; Orfila, J. E.; Busquet, N.; Tesic, V.; Valdez, R.; Fine-Raquet, B.; Jevtovic-Todorovic, V.; Raol, Y.; Herson, P.; Todorovic, S.

10.1101/2022.04.27.489701 — neuroscience — Posted on 2022-04-29

267 Cortex-wide fast activation of VIP-expressing inhibitory neurons by reward and punishment

Szadai, Z.; Pi, H.-J.; Chevy, Q.; Ocsai, K.; Albeanu, F.; Chiovini, B.; Szalay, G.; Katona, G.; Kepecs, A.; Rozsa, B.

10.1101/2022.04.27.489695 — neuroscience — Posted on 2022-04-29

268 Control becomes habitual early on when learning a novel motor skill

Yang, C. S.; Cowan, N. J.; Haith, A. M.

10.1101/2022.04.28.489941 — neuroscience — Posted on 2022-04-28

269 Evolutionary processes, not environmental drivers, determine the resilience of natural populations

Cant, J.; Capdevila, P.; Beger, M.; Salguero-Gomez, R.

10.1101/2022.04.28.489852 — ecology — Posted on 2022-04-28

270 Snip1-PRC2 governs the intrinsic apoptosis program in the developing brain

Matsui, Y.; Djekidel, M. N.; Lindsay, K.; Samir, P.; Connolly, N.; Chen, H.; Fan, Y.; Xu, B.; Peng, J. C.

10.1101/2022.04.27.489801 — developmental biology — Posted on 2022-04-28

271 Joint effect of temperature and insect chitosan on the heat resistance of Bacillus cereus spores in rice derivatives

Rodrigo, D.; Valdez, M. I.; Ubeda, M.; Narvaez, C.; Martinez, A.

10.1101/2022.04.28.489901 — microbiology — Posted on 2022-04-28

272 Pubertal Development Underlies Optimization of Inhibitory Control Through Specialization of Ventrolateral Prefrontal Cortex

Ravindranath, O.; Calabro, F. J.; Foran, W.; Luna, B.

10.1101/2022.04.28.489931 — neuroscience — Posted on 2022-04-28

273 Balancing selection on genomic deletion polymorphisms in humans

Aqil, A.; Speidel, L.; Pavlidis, P.; Gokcumen, O.

10.1101/2022.04.28.489864 — evolutionary biology — Posted on 2022-04-28

274 Nanoparticle coatings for controlled release of quercetin from an angioplasty balloon

Cracium, I.; Astete, C.; Boldor, D.; Jennings, M.; Gorman, J. R.; Sabliov, C.; Dugas, T. R.

10.1101/2022.04.28.489902 — pharmacology and toxicology — Posted on 2022-04-28

275 Variation in fine scale recombination rate in temperature-evolved Drosophila melanogaster populations in response to selection.

Winbush, A.; Singh, N. D.

10.1101/2022.04.28.489929 — evolutionary biology — Posted on 2022-04-28

276 Cytoplasmic processing of human transfer RNAs

Akiyama, Y.; Lyons, S. M.; Abe, T.; Anderson, P. J.; Ivanov, P.

10.1101/2022.04.28.489951 — molecular biology — Posted on 2022-04-28

277 MYXOBACTERIA FROM VIETNAM: ISOLATION, PHYLOGENETIC ANALYSIS AND BIOPROSPECTION

Nguyen, Y. T. N.; Duong, C. D.; Nguyen, H. T. K.; Nguyen, C. P.; Vo, N. T.; Dinh, L. T. L.; Nguyen, N. L. B.; Nguyen, T. M.; Nguyen, N. D.; Nguyen, A. T.

10.1101/2022.04.27.489816 — microbiology — Posted on 2022-04-28

278 Human anelloviruses produced by recombinant expression of synthetic genomes.

Nawandar, D. M.; Trivedi, M.; Bounoutas, G.; Lebo, K.; Prince, C.; Scano, C.; Agarwal, N.; Ozturk, E.; Yu, J.; Arze, C.; Bhattacharya, A.; Verma, D.; Thakker, P.; Cabral, J.; Liu, S.-H.; Swanson, K.; Swaminathan, H.; Diaz, F.; Mackey, A.; Chang, Y.; Ong, T.; Yozwiak, N. L.; Hajjar, R. H.; Delagrave, S.

10.1101/2022.04.28.489885 — microbiology — Posted on 2022-04-28

279 Sensory regulation of absence seizures in a mouse model of Gnb1 encephalopathy

Teng, S.; Zhen, F.; McRae, B. R.; Zhu, E.; Frankel, W. N.; Peng, Y.

10.1101/2022.04.28.489780 — neuroscience — Posted on 2022-04-28

280 RNA-seq sample preparation kits strongly affect transcriptome profiles of a gas-fermenting bacterium

de Lima, L. A.; Reinmets, K.; Nielsen, L. K.; Marcellin, E.; Harris, A.; Köpke, M.; Valgepea, K.

10.1101/2022.04.28.489910 — systems biology — Posted on 2022-04-28

281 ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

Chakraborty, A.; Bhalerao, N.; Marciel, M. P.; Hwang, J.; Britain, C.; Eltoum, E. E.; Jones, R. B.; Alexander, K. L.; Smythies, L. E.; Smith, P. D.; Crossman, D. K.; Crowley, M. R.; Shin, B.; Harrington, L. E.; Yan, Z.; Bethea, M. M.; Hunter, C. S.; Klug, C. A.; Buchsbaum, D. J.; Bellis, S. L.

10.1101/2022.04.28.489561 — cancer biology — Posted on 2022-04-28

282 Molecular Characterization of the Tumor Microenvironment in Renal Medullary Carcinoma

Tourigny, D. S.; Zucker, M.; Kim, M.; Russo, P.; Coleman, J.; Lee, C.-H.; Carlo, M. I.; Chen, Y.-B.; Hakimi, A. A.; Kotecha, R. R.; Reznik, E.

10.1101/2022.04.28.489873 — cancer biology — Posted on 2022-04-28

283 The "LINC" in between Δ40p53-miRNA axis in the regulation of cellular processes

Das, S.; Pal, A.

10.1101/2022.04.28.489891 — cancer biology — Posted on 2022-04-28

284 Quantitative analysis of surface wave patterns of Min proteins

Meindlhumer, S.; Kerssemakers, J.; Dekker, C.

10.1101/2022.04.28.489904 — biophysics — Posted on 2022-04-28

285 An Engineered Nanocomposite Copper Coating with Enhanced Antibacterial Efficacy

Nakhaie, D.; Williams, T. C.; Velapatino, B.; Bryce, E. A.; Charles, M. K.; Asselin, E.; Clifford, A. M.

10.1101/2022.04.28.489879 — bioengineering — Posted on 2022-04-28

286 The disordered N-terminus of McdB modulates phase separation via pH-sensitive hydration and folds upon interaction with McdA

Basalla, J. L.; Mak, C. A.; Limcaoco, M. J.; Hoang, Y.; Vecchiarelli, A. G.

10.1101/2022.04.28.489914 — biochemistry — Posted on 2022-04-28

287 Allosteric inhibition of PRPS is moderated by filamentous polymerization

Hu, H.; Lu, G.-M.; Chang, C.-C.; Li, Y.; Zhong, J.; Guo, C.-J.; Zhou, X.; Yin, B.; Zhang, T.; Liu, J.-L.

10.1101/2022.04.28.489849 — biochemistry — Posted on 2022-04-28

288 Cryo-EM structure of the Agrobacterium tumefaciens T-pilus reveals the importance of positive charges in the lumen

Amro, J.; Black, C.; Jemouai, Z.; Rooney, N.; Daneault, C.; Zeytuni, N.; Ruiz, M.; Bui, K. H.; Baron, C.

10.1101/2022.04.28.489814 — biochemistry — Posted on 2022-04-28

289 An auto-inhibited state of protein kinase G and implications for selective activation

Sharma, R.; Kim, J. J.; Qin, L.; Henning, P.; Akimoto, M.; VanSchouwen, B.; Kaur, G.; Sankaran, B.; MacKenzie, K. R.; Melacini, G.; Casteel, D. E.; Herberg, F. W.; Kim, C. W.

10.1101/2022.04.28.489861 — biochemistry — Posted on 2022-04-28

290 Phenotyping technology for assessing protein content in seaweed by field spectroscopy and a machine learning algorithm

Tadmor-Shalev, N.; Ghermandi, A.; Tchernov, D.; Shemesh, E.; Israel, A.; Brook, A.

10.1101/2022.04.27.489785 — biochemistry — Posted on 2022-04-28

291 Candidate Genes Underlying Wolbachia-Associated Plastic Recombination Revealed by Ovarian Transcriptomics of D. melanogaster

Franz, S. I.; Small, C. M.; Cresko, W. A.; Singh, N. D.

10.1101/2022.04.28.489783 — evolutionary biology — Posted on 2022-04-28

292 A human embryonic limb cell atlas resolved in space and time

Zhang, B.; He, P.; Lawrence, J. E.; Wang, S.; Tuck, E.; Williams, B. A.; Roberts, K.; Kleshchevnikov, V.; Mamanova, L.; Bolt, L.; Polanski, K.; Elmentaite, R.; Fasouli, E. S.; Prete, M.; He, X.; Yayon, N.; Fu, Y.; Yang, H.; Liang, C.; Zhang, H.; Fitzpatrick, D.; Firth, H.; Dean, A.; Marioni, J.; Barker, R. A.; Storer, M. A.; Wold, B.; Zhang, H.; Teichmann, S.

10.1101/2022.04.27.489800 — developmental biology — Posted on 2022-04-28

293 The 2',3' cyclic phosphatase Angel1 facilitates mRNA degradation during human ribosome-associated quality control

Nicholson-Shaw, T.; Ajaj, Y.; Perelis, M.; Fulzele, A.; Yeo, G. W.; Bennett, E. J.; Lykke-Anderson, J.

10.1101/2022.04.28.489582 — molecular biology — Posted on 2022-04-28

294 The antibiotic phazolicin displays a dual mode of uptake in Gram-negative bacteria

Travin, D. Y.; Vigouroux, A.; Inaba-Inoue, S.; Qu, F.; Jouan, R.; Lachat, J.; Sutormin, D.; Dubiley, S.; Beis, K.; MORERA, S.; Severinov, K. V.; Mergaert, P.

10.1101/2022.04.27.489825 — molecular biology — Posted on 2022-04-28

295 MTALTND4, a second protein coded by nd4 impacts mitochondrial bioenergetics

Kienzle, L.; Bettinazzi, S.; Brunet, M.; Choquette, T.; Khorami, H. H.; Roucou, X.; Landry, C. R.; Angers, A.; Breton, S.

10.1101/2022.04.28.489924 — molecular biology — Posted on 2022-04-28

296 Prolonged exposure to insulin causes epigenetic alteration leading to insulin resistance

Bano, S.; More, S.; Mongad, D.; Khalique, A.; Dhotre, D.; Bhat, M.; Seshadri, V.

10.1101/2022.04.28.489884 — molecular biology — Posted on 2022-04-28

297 Conserved FimK truncation coincides with increased expression of type 3 fimbriae and cultured bladder epithelial cell association in Klebsiella quasipneumoniae

Venkitapathi, S.; Wijesundara, Y. H.; Herbert, F. C.; Gassensmith, J. J.; Zimmern, P. E.; De Nisco, N. J.

10.1101/2022.04.27.489788 — microbiology — Posted on 2022-04-28

298 Different Routes for Direct Interspecies Electron Transfer with Diverse Electron-Accepting Partners

Holmes, D.; Zhou, J.; Smith, J. A.; Wang, C.; Liu, X.; Lovley, D.

10.1101/2022.04.27.489562 — microbiology — Posted on 2022-04-28

299 Tackling Recalcitrant Pseudomonas aeruginosa Infections In Critical Illness via Anti-virulence Monotherapy

SINGH, V. K.; Almpani, M.; Maura, D.; Kitao, T.; Ferrari, L.; Fontana, S.; Bergamini, G.; Calcaterra, E.; Pignaffo, C.; Negri, M.; Oliveira Pereira, T. d.; Skinner, F.; Gkikas, M.; Andreotti, D.; Felici, A.; Deziel, E.; Lepine, F.; Rahme, L. G.

10.1101/2022.04.27.489723 — microbiology — Posted on 2022-04-28

300 IgaA protein, GumB, has a global impact on the transcriptome and surface proteome of Serratia marcescens

Stella, N. A.; Romanowski, E. G.; Brothers, K. M.; Shanks, R. M.

10.1101/2022.04.27.489824 — microbiology — Posted on 2022-04-28

301 An essential host dietary fatty acid promotes TcpH inhibition of TcpP proteolysis enabling virulence gene expression in Vibrio cholerae

Demey, L. M.; Sinha, R.; DiRita, V. J.

10.1101/2022.04.28.489952 — microbiology — Posted on 2022-04-28

302 Persistence and in vivo evolution of vaginal bacterial strains over a multi-year time period

France, M. T.; Ma, B.; Ravel, J.

10.1101/2022.04.27.489821 — microbiology — Posted on 2022-04-28

303 A Neuropeptidergic Signaling Pathway for Olfactory Gain Modulation

Sizemore, T. R.; Jonaitis, J.; Dacks, A. M.

10.1101/2022.04.27.489804 — neuroscience — Posted on 2022-04-28

304 Hyperactive somatostatin interneurons near amyloid plaque and cell-type-specific firing deficits in a mouse model of Alzheimer's disease

Algamal, M.; Russ, A. N.; Miler, M. R.; Hou, S. S.; Maci, M.; Munting, L. P.; Zhao, Q.; Gerashchenko, D.; Bacskai, B. J.; Kastanenka, K. V.

10.1101/2022.04.27.489759 — neuroscience — Posted on 2022-04-28

305 A Pan-Coronavirus Vaccine Candidate: Nine Amino Acid Substitutions in the ORF1ab Gene Attenuate 99% of 365 Unique Coronaviruses: A Comparative Effectiveness Research Study

Luellen, E.

10.1101/2022.04.28.489618 — synthetic biology — Posted on 2022-04-28

306 Characterization of the cluster MabR prophages of Mycobacterium abscessus and Mycobacterium chelonae

Cote, J.; Welch, C.; Kimble, M.; Archambault, D.; Ross, J. C.; Orellana, H.; Amero, K.; Bourett, C.; Daigle, A.; Hutchison, K. W.; Molloy, S. D.

10.1101/2022.04.27.489733 — genomics — Posted on 2022-04-28

307 Chromoanagenesis in the asy1 meiotic mutant of Arabidopsis

Henry, I. M.; Comai, L.; Guo, W.

10.1101/2022.04.27.489737 — genomics — Posted on 2022-04-28

308 The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

Barut, T.; Halwe, N. J.; Taddeo, A.; Kelly, J. N.; Schön, J.; Ebert, N.; Ulrich, L.; Devisme, C.; Steiner, S.; Trueeb, B. S.; Hoffmann, B.; Veiga, I. B.; Leborgne, N. F. G.; Moreira, E. A.; Breithaupt, A.; Wylezich, C.; Höper, D.; Wernike, K.; Godel, A.; Thomann, L.; Flück, V.; Stalder, H.; Brügger, M.; Esteves, B. I. O.; Zumkehr, B.; Beilleau, G.; Kratzel, A.; Schmied, K.; Ochsenbein, S.; Lang, R. M.; Wider, M.; Machahua, C.; Dorn, P.; Marti, T. M.; Funke-Chambour, M.; Rauch, A.; Widera, M.; Ciesek, S.; Dijkman, R.; Hoffmann, D.; Alves, M. P.; Benarafa, C.; Beer, M.; Thiel, V.

10.1101/2022.04.28.489537 — microbiology — Posted on 2022-04-28

309 Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike

Zhang, J.; Weichun, T.; Gao, H.; Lavine, C.; Shi, W.; Peng, H.; Zhu, H.; Anand, K.; Kosikova, M.; Kwon, H. J.; Tong, P.; Gautam, A.; Rits-Volloch, S.; Wang, S.; Mayer, M. L.; Wesemann, D.; Seaman, M. S.; Lu, J.; Xiao, T.; Xie, H.; Chen, B.

10.1101/2022.04.28.489772 — microbiology — Posted on 2022-04-28

310 GM-CSF-activated human dendritic cells promote type1 T follicular helper cells (Tfh1) polarization in a CD40-dependent manner

Korniotis, S.; Saichi, M.; Trichot, C.; Hoffmann, C.; Amblard, E.; Viguier, A.; Grondin, S.; Noel, F.; Mattoo, H.; Soumelis, V.

10.1101/2022.04.28.489850 — immunology — Posted on 2022-04-28

311 Two types of human TCR differentially regulate reactivity to self and non-self antigens

Trofimov, A.; Brouillard, P.; Larouche, J.-D.; Seguin, J.; Laverdure, J.-P.; Brasey, A.; Ehx, G.; Roy, D.-C.; Busque, L.; Lachance, S.; Lemieux, S.; Perreault, C.

10.1101/2022.04.27.489747 — immunology — Posted on 2022-04-28

312 Impact of freeze-thaw-induced pit aspiration on stem water transport in a subalpine conifer (Abies veitchii)

Taneda, H.; Ogasa, M.; Yazaki, K.; Funayama-Nogichi, S.; Miyazawa, Y.; Mayr, S.; Maruta, E.

10.1101/2022.04.27.489725 — plant biology — Posted on 2022-04-28

313 Stardust: improving spatial transcriptomics data analysis through space aware modularity optimization based clustering.

Avesani, S.; Viesi, E.; Alessandrì, L.; Motterle, G.; Bonnici, V.; Beccuti, M.; Calogero, R.; Giugno, R.

10.1101/2022.04.27.489655 — bioinformatics — Posted on 2022-04-28

314 Ligand Binding Prediction using Protein Structure Graphs and Residual Graph Attention Networks

Pandey, M.; Radaeva, M.; Mslati, H.; Garland, O.; Fernandez, M.; Ester, M.; Cherkasov, A.

10.1101/2022.04.27.489750 — bioinformatics — Posted on 2022-04-28

315 AnkG-Neurofascin complex structure reveals binding mechanisms required for integrity of the AIS

WANG, C.

10.1101/2022.04.27.489743 — biochemistry — Posted on 2022-04-28

316 Regulated use of alternative Transcription Start Sites controls the production of cytosolic or mitochondrial forms of branched-chain aminotransferase in Kluyveromyces marxianus

Morrissey, J.; Coral-Medina, A. M.; Fenton, D. A.; Valela, J.; Camarasa, C.; Baranov, P. B.

10.1101/2022.04.27.489738 — genetics — Posted on 2022-04-28

317 How to measure response diversity

Ross, S. R. P.-J.; Petchey, O. L.; Sasaki, T.; Armitage, D. W.

10.1101/2022.04.26.489626 — ecology — Posted on 2022-04-28

318 Drosophila Keap1 oxidative/xenobiotic response factor interacts with B-type lamin to regulate nuclear lamina and heterochromatin

Deng, H.; Carlson, J.; Neidviecky, E.; Cook, I.

10.1101/2022.04.27.489742 — cell biology — Posted on 2022-04-28

319 Removal of Clinically Relevant SARS-CoV-2 Variants by An Affinity Resin Containing Galanthus nivalis Agglutinin

Gooldy, M.; Roux, C. M.; LaRosa, S. P.; Spaulding, N.; Fisher, C. J.

10.1101/2022.04.27.489436 — microbiology — Posted on 2022-04-28

320 Diet induced obesity and type 2 diabetes drives exacerbated sex-associated disease profiles in K18-hACE2-mice challenged with SARS-CoV-2

Lee, K.; Russ, B.; Wong, T.; Horspool, A. M.; Winters, M. T.; Barbier, M.; Bevere, J. R.; Martinez, I.; Damron, F. H.; Cyphert, H. A.

10.1101/2022.04.26.489580 — immunology — Posted on 2022-04-28

321 Induction of neutralizing antibodies against SARS-CoV-2 variants by a multivalent mRNA-lipid nanoparticle vaccine encoding SARS-CoV-2/SARS-CoV Spike protein receptor-binding domains

Zhang, Q.; Tiwari, S. K.; Wang, S.; Wang, L.; Li, W.; Zhang, L.; Rawlings, S. A.; Cheng, Y.; Jokerst, J. V.; Rana, T. M.

10.1101/2022.04.28.489834 — immunology — Posted on 2022-04-28

322 Robust cone-mediated signaling persists late into rod photoreceptor degeneration

Scalabrino, M. L.; Thapa, M.; Chew, L. A.; Zhang, E.; Xu, J. Q.; Sampath, A.; Chen, J.; Field, G. D.

10.1101/2022.04.27.489758 — neuroscience — Posted on 2022-04-28

Hinault, T. T.; Baillet, S. T.; Courtney, S.

10.1101/2022.04.27.489652 — neuroscience — Posted on 2022-04-28

324 HSP90.6 is involved in grain filling via carbon and nitrogen metabolism in maize.

Xu, J.; Yang, Z.; Fei, X.; Zhang, M.; Cui, Y.; zhang, X.; Tan, K.; E, L.; Zhao, H.; Lai, J.; Zhao, Q.; Song, W.

10.1101/2022.04.27.489727 — plant biology — Posted on 2022-04-28

325 Defining the age-dependent and tissue-specific circadian transcriptome in male mice

Wolff, C. A.; Gutierrez-Monreal, M. A.; Meng, L.; Zhang, X.; Douma, L. G.; Costello, H. M.; Douglas, C. M.; Ebrahimi, E.; Alava, B. R.; Morris, A. R.; Endale, M. M.; Crislip, G. R.; Cheng, K.-y.; Schroder, E. A.; Delisle, B. P.; Bryant, A. J.; Gumz, M. L.; Huo, Z.; Liu, A. C.; Esser, K. A.

10.1101/2022.04.27.489594 — genomics — Posted on 2022-04-28

326 Wastewater microorganisms impact microbial diversity and important ecological functions of stream periphyton

Carles, L.; Wullschleger, S.; Joss, A.; Eggen, R.; Schirmer, K.; Schuwirth, N.; Stamm, C.; Tlili, A.

10.1101/2022.04.27.489724 — ecology — Posted on 2022-04-28

327 Purification of mitochondria from skeletal muscle tissue for transcriptomic analyses reveals localisation of nuclear-encoded non-coding RNAs

Silver, J.; Trewin, A. J.; Loke, S.; Croft, L.; Ziemann, M. J.; Dillon, H.; Nielsen, S.; Lamon, S.; Wadley, G. D.

10.1101/2022.04.27.489477 — cell biology — Posted on 2022-04-28

328 EGFR inhibition stabilizes cardiomyocyte cohesion in a murine arrhythmogenic cardiomyopathy model

Shoykhet, M.; Dervishi, O.; Menauer, P.; Hiermaier, M.; Waschke, J.; Yeruva, S.

10.1101/2022.04.27.489705 — cell biology — Posted on 2022-04-28

329 Rac rather than Rho drives the early transcriptional response to extracellular matrix stiffness and mediates repression of ATF3

Dang, I.; Bae, Y.; Assoian, R. K.

10.1101/2022.04.27.489717 — cell biology — Posted on 2022-04-28

330 Light 'em up: efficient screening of gold grids in cryo-EM

Hagen, W. J.

10.1101/2022.04.27.489675 — molecular biology — Posted on 2022-04-28

331 Equilibrative Nucleoside Transporter 3 is an IFN-stimulated Gene that Facilitates Viral Genome Release

Hsieh, Y.-T.; Tsai, T.-L.; Tu, C.-C.; Huang, S.-Y.; Heng, J.-W.; Tsai, P.-Y.; Chao, T.-L.; Tsai, Y.-M.; Chang, P.-C.; Lee, C.-K.; Yu, G.-Y.; Chang, S.-Y.; Dzhagalov, I.; Hsu, C.-L.

10.1101/2022.04.27.489746 — immunology — Posted on 2022-04-28

332 Cortical magnification underlies differences across but not around the visual field

Jigo, M.; Carrasco, M.; Tavdy, D.

10.1101/2022.04.27.489757 — neuroscience — Posted on 2022-04-28

333 How do Protein Contaminants Influence DDA and DIA Proteomics

Frankenfield, A. M.; Ni, J.; Ahmed, M.; Hao, L.

10.1101/2022.04.27.489766 — systems biology — Posted on 2022-04-28

334 The localization of PHRAGMOPLAST ORIENTING KINESIN1 at the division site depends on two microtubule binding proteins TANGLED1 and AUXIN-INDUCED-IN-ROOT-CULTURES9 in Arabidopsis.

Mills, A. M.; Morris, V. H.; Rasmussen, C.

10.1101/2022.04.27.489732 — plant biology — Posted on 2022-04-28

335 Differential genetic variation underlying Ammonium and Nitrate responses in Arabidopsis thaliana

Katz, E.; Knapp, A.; Lensink, M.; Stefani, J.; Li, J.-J.; Shane, E.; Tuermer-Lee, K.; Bloom, A. J.; Kliebenstein, D. J.

10.1101/2022.04.27.489730 — plant biology — Posted on 2022-04-28

336 miRNA408 and its encoded peptide, miPEP408, regulate arsenic stress response in Arabidopsis

Kumar, R. S.; Singh, H.; Datta, T.; Asif, M. H.; Trivedi, P. K.

10.1101/2022.04.27.489731 — plant biology — Posted on 2022-04-28

337 Receptor-like kinases FER and SRK mediate Lotus japonicus freezing tolerance and climate adaptation

Mustamin, Y.; Akyol, T. Y.; Gordon, M.; Manggabarani, A. M.; Isomura, Y.; Kawamura, Y.; Bamba, M.; Williams, C. M.; Andersen, S. U.; Sato, S.

10.1101/2022.04.27.489728 — plant biology — Posted on 2022-04-28

338 Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

Bryant, D.; Smith, L.; Rogers-Broadway, K. R.; Karydis, L.; Woo, J.; Blunt, M. D.; Forconi, F.; Stevenson, F. K.; Goodnow, C.; Humberg, P.; Russell, A.; Packham, G. K.; Steele, A. J.; Strefford, J. C.

10.1101/2022.04.26.487675 — cancer biology — Posted on 2022-04-28

339 Metformin decreases Cyp26a1 to prevent hepatocarcinogenesis through down- regulating CD8+ T cells

He, Z.; He, W.; Chen, M.; Li, C.; Wang, X.; Chen, W.; Pan, L.; Cui, Y.; Yu, Z.; Wu, G.; Yang, Y.; Tang, Q.; Wang, J.

10.1101/2022.04.27.489721 — cancer biology — Posted on 2022-04-28

340 Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2

Liauw, B. W.-H.; Foroutan, A.; Schamber, M. R.; Lu, W.; Samareh Afsari, H.; Vafabakhsh, R.

10.1101/2022.04.27.489706 — biophysics — Posted on 2022-04-28

341 A reverse vaccinology approach identifies putative vaccination targets in the zoonotic nematode Ascaris.

Evangelista, F. M. D.; van Vliet, A. H. M.; Lawton, S. P.; Betson, M.

10.1101/2022.04.27.489657 — bioinformatics — Posted on 2022-04-28

342 From defaults to databases: parameter and database choice dramatically impact the performance of metagenomic taxonomic classification tools

Wright, R. J.; Comeau, A. M.; Langille, M. G. I.

10.1101/2022.04.27.489753 — bioinformatics — Posted on 2022-04-28

343 Integrated Genomics Approaches Identify Mediators of Transcriptional and Epigenetic Responses to Afghan Desert Particulate Matter in Human Small Airway Epithelial Cells

Gupta, A.; Sasse, S.; Berman, R.; Gruca, M.; Dowell, R. D.; Chu, H. W.; Downey, G. P.; Gerber, A. N.

10.1101/2022.04.27.489761 — genomics — Posted on 2022-04-28

344 Chronic nicotine exposure alters sperm small RNA content in a C57BL/6J mouse model: Implications for multigenerational inheritance

Zeid, D.; Gould, T.

10.1101/2022.04.27.489636 — genetics — Posted on 2022-04-28

345 The climatic constrains of the historical global spread of mungbean

Ong, P.-W.; Lin, Y.-P.; Chen, H.-W.; Lo, C.-Y.; Burlyaeva, M.; Noble, T.; Nair, R. M.; Schafleitner, R.; Vishnyakova, M.; von Wettberg, E.; Samsonova, M. G.; Nuzhdin, S.; Ting, C.-T.; Lee, C.-R.

10.1101/2022.04.27.489711 — evolutionary biology — Posted on 2022-04-28

346 ATP6AP2-to-MMP14, a key pathway for osteoblast to osteocyte transition

Xiong, L.; Guo, H.-H.; PAN, J.-X.; Ren, X.; Lee, D.; Mei, L.; Xiong, W.-C.

10.1101/2022.04.27.489713 — developmental biology — Posted on 2022-04-28

347 Targeting Apollo-NADP+ to image NADPH generation in pancreatic beta-cell organelles

Chang, H. H.; Bennett, A. M.; Cameron, W. D.; Floro, E.; Au, A.; McFaul, C. M.; Yip, C. M.; Rocheleau, J. V.

10.1101/2022.04.27.489691 — cell biology — Posted on 2022-04-28

348 Induction of Sis1 promotes fitness but not feedback in the heat shock response

Garde, R.; Singh, A.; Ali, A.; Pincus, D.

10.1101/2022.04.27.489698 — cell biology — Posted on 2022-04-28

349 Competition between severing and tubulin induced repair of microtubules

Shiff, C. E.; Kondev, J.; Mohapatra, L.

10.1101/2022.04.26.488783 — cell biology — Posted on 2022-04-28

350 Parkinson mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1

Jacquemyn, J.; Kuenen, S.; Swerts, J.; Pavie, B.; Vijayan, V.; Kilic, A.; Chabot, D.; Wang, Y.-C.; Schoovaerts, N.; Verstreken, P.

10.1101/2022.04.27.489745 — cell biology — Posted on 2022-04-28

351 A toolbox for systematic discovery of stable and transient protein interactors in baker's yeast

Fenech, E. J.; Cohen, N.; Kupervaser, M.; Gazi, Z.; Schuldiner, M.

10.1101/2022.04.27.489741 — molecular biology — Posted on 2022-04-28

352 Two enhancer binding proteins activate σ54 -dependent transcription of a quorum regulatory RNA in a bacterial symbiont

Surrett, E. D.; Guckes, K. R.; Cousins, S.; Ruskoski, T. B.; Cecere, A. G.; Ludvik, D. A.; Okafor, C. D.; Mandel, M.; Miyashiro, T.

10.1101/2022.04.27.489697 — microbiology — Posted on 2022-04-28

353 The single-cell atlas of the murine reproductive tissues during preterm labor

Garcia-Flores, V.; Romero, R.; Peyvandipour, A.; Galaz, J.; Pusod, E.; Panaitescu, B.; Miller, D.; Xu, Y.; Tao, L.; Liu, Y.; Tarca, A. L.; Pique-Regi, R.; Nardhy Gomez-Lopez, N.

10.1101/2022.04.27.489704 — immunology — Posted on 2022-04-28

354 SARM1 activation and its downstream pathways are distinct in neuronal compartments

Miyamoto, T.; Kim, C.; Chow, J.; Dugas, J. C.; DeGroot, J.; Bagdasarian, A. L.; Thottumkara, A. P.; Larhammar, M.; Calvert, M. E.; Fox, B. M.; Lewcock, J. W.; Kane, L. A.

10.1101/2022.04.27.489702 — neuroscience — Posted on 2022-04-28

355 Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior

McLachlan, I. G.; Kramer, T. S.; Dua, M.; DiLoreto, E. M.; Srinivasan, J.; Dag, U.; Flavell, S. W.

10.1101/2022.04.27.489714 — neuroscience — Posted on 2022-04-28

356 Dapagliflozin improves endothelial integrity and hemodynamics in endotoxin treated mice through an apolipoprotein M dependent pathway

Valenzuela Ripoll, C.; Guo, Z.; Kumari, T.; Miyata, K. N.; Ozcan, M.; Diab, A.; Girardi, A.; He, L.; Kovacs, A.; Weinheimer, C. J.; Nigro, J.; Oscarsson, J.; Esterline, R.; Schilling, J.; Kosiborod, M.; Christoffersen, C.; Cho, J.; Javaheri, A.

10.1101/2022.04.27.489709 — physiology — Posted on 2022-04-28

357 Trait anxiety is associated with hidden state inference during aversive reversal learning

Zika, O.; Wiech, K.; Reinecke, A.; Browning, M.; Schuck, N. W.

10.1101/2022.04.01.483303 — neuroscience — Posted on 2022-04-28

358 Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models

Guo, T.; Pan, X.; Jiang, G.; Zhang, D.; Qi, J.; Shao, L.; Wang, Z.; Xu, H.; Zhao, Y.

10.1101/2022.04.27.489696 — neuroscience — Posted on 2022-04-28

359 Fast, high-throughput production of improved rabies viral vectors for specific, efficient and versatile transsynaptic retrograde labeling

Sumser, A.; Joesch, M.; Jonas, P.; Ben-Simon, Y.

10.1101/2021.12.23.474014 — neuroscience — Posted on 2022-04-28

360 tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel

Nandi, T.; Puonti, O.; Clarke, W. T.; Nettekoven, C.; Barron, H. C.; Kolasinski, J.; Hanayik, T.; Hinson, E. L.; Berrington, A.; Bachtiar, V.; Johnstone, A.; Winkler, A. M.; Thielscher, A.; Johansen-Berg, H.; Stagg, C. J.

10.1101/2022.04.27.489665 — neuroscience — Posted on 2022-04-28

361 ALFF Response Interaction With Learning During Feedback in Individuals With Multiple Sclerosis

Dobryakova, E.; Hafiz, R.; Iosipchuk, O.; Sandry, J.; Biswal, B.

10.1101/2022.04.27.489552 — neuroscience — Posted on 2022-04-28

362 The regulation of circadian rhythm by insulin signaling in Drosophila

Yamaguchi, S. T.; Tomita, J.; Kume, K.

10.1101/2022.04.25.489482 — animal behavior and cognition — Posted on 2022-04-28

363 Early life trauma leads to escalated aggressive behavior and its inheritance by impairing thyroid hormone availability in brain

Rawat, R. S.; Bhambri, A.; Pal, M.; Roy, A.; Jain, S.; Pillai, B.; Konar, A.

10.1101/2021.07.05.448713 — neuroscience — Posted on 2022-04-28

364 Control-based continuation: a new approach to prototype synthetic gene networks

de Cesare, I.; Salzano, D.; di Bernardo, M.; Renson, L.; Marucci, L.

10.1101/2021.12.21.473142 — synthetic biology — Posted on 2022-04-28

365 If Research is Not the Evidence, What is it? The Lack of Research Citations in Health Vlogs

Atef, N.

10.1101/2022.04.25.489430 — scientific communication and education — Posted on 2022-04-28

366 Smart soils to observe hidden rhizosphere processes

Patko, D.; Yang, Q.; Liu, Y.; Falireas, P.; Briou, B.; Tawade, B. V.; George, T. S.; Daniell, T. J.; MacDonald, M. P.; Ladmiral, V.; Ameduri, B.; Dupuy, L. X.

10.1101/2021.11.19.468202 — plant biology — Posted on 2022-04-28

367 Experimental evolution in TP53 deficient human gastric organoids recapitulates tumorigenesis

Karlsson, K.; Przybilla, M. J.; Xu, H.; Kotler, E.; Karagyozova, K.; Sockell, A.; Liu, K.; Mah, A.; Lo, Y.-H.; Lu, B.; Houlahan, K. E.; Khan, A.; Ma, Z.; Suarez, C. J.; Barnes, C. P.; Kuo, C. J.; Curtis, C.

10.1101/2022.04.09.487529 — cancer biology — Posted on 2022-04-28

368 A comprehensive Bioconductor ecosystem for the design of CRISPR guide RNAs across nucleases and technologies

Hoberecht, L.; Perampalam, P.; Lun, A.; Fortin, J.-P.

10.1101/2022.04.21.488824 — bioinformatics — Posted on 2022-04-28

369 Putative host-derived insertions in the genome of circulating SARS-CoV-2 variants

Yang, Y.; Dufault-Thompson, K.; Fontenele, R. S.; Jiang, X.

10.1101/2022.01.04.474799 — bioinformatics — Posted on 2022-04-28

370 Are tropical hummingbird pollination networks resistant to experimental extirpation of a common flowering plant?

Leimberger, K. G.; Hadley, A. S.; Frey, S. J. K.; Betts, M. G.

10.1101/2022.02.24.481682 — ecology — Posted on 2022-04-28

371 NO-stressed Y. pseudotuberculosis have decreased cell division rates in the mouse spleen

Liu, B.; Braza, R. E. D.; Cotten, K. L.; Davidson, R. K.; Davis, K. M.

10.1101/2021.08.04.455180 — microbiology — Posted on 2022-04-28

372 An automated model reduction tool to guide the design and analysis of synthetic biological circuits

Pandey, A.; Murray, R. M.

10.1101/640276 — synthetic biology — Posted on 2022-04-28

373 Regulation of invasion-associated actin dynamics by the Chlamydia trachomatis effectors TarP and TmeA

Romero, M. D.; Carabeo, R. A.

10.1101/2021.11.04.467231 — cell biology — Posted on 2022-04-28

374 Controllability boosts neural and cognitive signatures of information seeking

Rouault, M.; Weiss, A.; Lee, J. K.; Drugowitsch, J.; Chambon, V.; Wyart, V.

10.1101/2021.01.04.425114 — neuroscience — Posted on 2022-04-28

375 Lhx9 haploinsufficiency alters transcription in the adult mouse ovary, causing subfertility and abnormal epithelium

Workman, S.; Wilson, M. J.

10.1101/2022.04.27.489797 — developmental biology — Posted on 2022-04-28

376 Inhibiting presynaptic calcium channel mobility in the auditory cortex suppresses synchronized input processing

Deane, K. E.; Klymentiev, R.; Heck, J.; Mark, M. D.; Ohl, F. W.; Heine, M.; Happel, M. F. K.

10.1101/2022.03.30.486338 — neuroscience — Posted on 2022-04-28

377 Symbiosis increases population size and buffers environmental fluctuations in a physiologically-structured model parameterized for thyasirid bivalves

Marino, J.; Dufour, S. C.; Hurford, A.

10.1101/2021.06.02.446784 — ecology — Posted on 2022-04-28

378 Staphylococcus aureus prophages are gatekeepers of lipid utilization to control membrane flexibility, bacterial fitness, and antibiotic adaptation

Zhou, B.; Pathania, A.; Pant, D.; Halpern, D.; Gaudu, P.; Trieu-Cuot, P.; Gruss, A.; Gloux, K.

10.1101/2022.01.27.478126 — microbiology — Posted on 2022-04-28

379 Kidins220 regulates the development of B cells bearing the {lambda} light chain

Schaffer, A.-M.; Fiala, G. J.; Hils, M.; Natali, E.; Babrak, L.; Herr, L. A.; Rizzi, M.; Miho, E.; Schamel, W.; Minguet, S.

10.1101/2022.04.04.486937 — immunology — Posted on 2022-04-28

380 Disease diagnostics using machine learning of immune receptors

Zaslavsky, M. E.; Ram-Mohan, N.; Guthridge, J. M.; Merrill, J. T.; Goldman, J. D.; Lee, J.-Y.; Roskin, K. M.; Cunningham-Rundles, C.; Moody, M. A.; Haynes, B. F.; Pinsky, B. A.; Heath, J. R.; James, J. A.; Yang, S.; Blish, C. A.; Tibshirani, R.; Kundaje, A.; Boyd, S. D.

10.1101/2022.04.26.489314 — immunology — Posted on 2022-04-28

381 Neural dynamics and architecture of the heading direction circuit in a vertebrate brain

Petrucco, L.; Lavian, H.; Wu, Y. K.; Svara, F.; Stih, V.; Portugues, R.

10.1101/2022.04.27.489672 — neuroscience — Posted on 2022-04-28

382 Spleen voltammetry assesses in real time norepinephrine release elicited by autonomic stimulation

Mughrabi, I. T.; Gerber, M.; Jayaprakash, N.; Al-Abed, Y.; Zanos, S.

10.1101/2022.04.26.489592 — neuroscience — Posted on 2022-04-28

383 Truncated suPAR simultaneously causes kidney disease and autoimmune diabetes mellitus

Zhu, K.; Mukherjee, K.; Wei, C.; Hayek, S. S.; Collins, A.; Gu, C.; Corapi, K.; Altintas, M. M.; Wang, Y.; Sushrut, W. S.; Bianco, A. C.; Reiser, J.; Sever, S.

10.1101/2022.04.26.489589 — physiology — Posted on 2022-04-28

384 Liposome-assisted in-situ cargo delivery to artificial cells and cellular subcompartments

Xue, L.; Stephenson, A. B.; Gözen, I.

10.1101/2022.04.27.489538 — biophysics — Posted on 2022-04-28

385 Extension of PERMANOVA to Testing the Mediation Effect of the Microbiome

Yue, Y.; Hu, Y.

10.1101/2022.04.26.489586 — bioinformatics — Posted on 2022-04-28

386 Detecting epistatic interactions in genomic data using Random Forests

Al-Mamun, H. A.; Dunne, R.; Tellam, R. L.; Verbyla, K.

10.1101/2022.04.26.488110 — bioinformatics — Posted on 2022-04-28

387 Characterizing dynamic neural representations of scene attractiveness

Kaiser, D.

10.1101/2022.04.27.489648 — neuroscience — Posted on 2022-04-28

388 neuroWalknet, a controller for hexapod walking allowing for context dependent behavior

Schilling, M.; Cruse, H.

10.1101/2022.04.27.489633 — neuroscience — Posted on 2022-04-28

389 Structural insights into the high selectivity of the anti-diabetic drug mitiglinide

Wang, M.; Wu, J.-X.; Chen, L.

10.1101/2022.04.26.489624 — biophysics — Posted on 2022-04-28

390 Fast and Optimal Sequence-to-Graph Alignment Guided by Seeds

Ivanov, P.; Bichsel, B.; Vechev, M.

10.1101/2021.11.05.467453 — bioinformatics — Posted on 2022-04-28

391 Conditional Generative Modeling for De Novo Protein Design with Hierarchical Functions

Kucera, T.; Togninalli, M.; Meng-Papaxanthos, L.

10.1101/2021.11.10.467885 — bioinformatics — Posted on 2022-04-28

392 A fast machine-learning-guided primer design pipeline for selective whole genome amplification

Yu, J. A.; Oppler, Z. J.; Mitchell, M. W.; Song, Y. S.; Brisson, D.

10.1101/2022.04.27.489632 — genomics — Posted on 2022-04-28

393 Variable paralog expression underlies phenotype variation

Bailon-Zambrano, R.; Sucharov, J.; Mumme-Monheit, A.; Murry, M.; Stenzel, A.; Pulvino, A. T.; Mitchell, J.; Colborn, K. L.; Nichols, J.

10.1101/2022.04.27.489692 — genetics — Posted on 2022-04-28

394 Tracing genetic connections of ancient Hungarians to the 6-14th century populations of the Volga-Ural region

Szeifert, B.; Gerber, D.; Csaky, V.; Lango, P.; Stashenkov, D. A.; Khokhlov, A. A.; Sitdikov, A. G.; Gazimzyanov, I. R.; Volkova, E. V.; Matveeva, N. P.; Zelenkov, A. S.; Poshekhonova, O. E.; Sleptsova, A. V.; Karacharov, K. G.; Ilyushina, V. V.; Konikov, B. A.; Sungatov, F. A.; Kolonskikh, A. G.; Botalov, S. G.; Grudochko, I. V.; Komar, O.; Egyed, B.; Mende, B. G.; Turk, A.; Szecsenyi-Nagy, A.

10.1101/2022.02.04.478947 — genetics — Posted on 2022-04-28

395 The distribution of the Lansing Effect across animal species

Ivimey-Cook, E. R.; Shorr, S.; Moorad, J.

10.1101/2022.04.27.489689 — evolutionary biology — Posted on 2022-04-28

396 High Concentrations of floating life in the North Pacific Garbage Patch

Helm, R. R.; Chong, F.; Spencer, M.; Maximenko, N.; Hafner, J.; McWhirter, A.

10.1101/2022.04.26.489631 — ecology — Posted on 2022-04-28

397 Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

Oda, T.; Yanagisawa, H.; Shinmori, H.; Ogawa, Y.; Kawamura, T.

10.1101/2022.02.24.481763 — immunology — Posted on 2022-04-28

398 Genome-wide CRISPRi screening reveals regulators of Alzheimee's tau pathology shared between exosomal and vesicle-free tau seeds.

Polanco, J. C.; Akimov, Y.; Fernandes, A.; Hand, G. R.; Briner, A.; van Roijen, M.; Balistreri, G.; Gotz, J.

10.1101/2022.04.26.489622 — neuroscience — Posted on 2022-04-28

399 ULTRASTRUCTURAL ANALYSIS OF CRF-DA INTERACTIONS IN MALE AND FEMALE MACAQUE: BEYOND THE CLASSIC VTA

Kelly, E. A.; Fudge, J. L.

10.1101/2022.04.26.489587 — neuroscience — Posted on 2022-04-28

400 Parameter inference on brain network models with unknown node dynamics and spatial heterogeneity

Sip, V.; Petkoski, S.; Hashemi, M.; Dickscheid, T.; Amunts, K.; Jirsa, V. K.

10.1101/2021.09.01.458521 — neuroscience — Posted on 2022-04-28

401 Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties

Triebelhorn, J.; Cardon, I.; Kuffner, K.; Bader, S.; Jahner, T.; Meindl, K.; Rothhammer-Hampl, T.; Riemenschneider, M. J.; Drexler, K.; Berneburg, M.; Nothdurfter, C.; Manook, A.; Brochhausen, C.; Baghai, T. C.; Hilbert, S.; Rupprecht, R.; Milenkovic, V. M.; Wetzel, C. H.

10.1101/2021.04.30.441774 — neuroscience — Posted on 2022-04-28

402 Neural basis for anxiety and anxiety-related physiological responses during a driving situation: An fMRI study

Sasaoka, T.; Harada, T.; Sato, D.; Michida, N.; Yonezawa, H.; Takayama, M.; Nouzawa, T.; Yamawaki, S.

10.1101/2021.11.30.470539 — neuroscience — Posted on 2022-04-28

403 Improved sequence mapping using a complete reference genome and lift-over

Chen, N.-C.; Paulin, L. F.; Sedlazeck, F. J.; Koren, S.; Phillippy, A. M.; Langmead, B.

10.1101/2022.04.27.489683 — bioinformatics — Posted on 2022-04-28

404 Systematic Replication Enables Normalization of High-throughput Imaging Assays

Hunt, G. J.; Dane, M. A.; Korkola, J. E.; Heiser, L. M.; Gagnon-Bartsch, J. A.

10.1101/2022.04.26.489617 — bioinformatics — Posted on 2022-04-28

405 ConsAlign: simultaneous RNA structural aligner based on rich transfer learning and thermodynamic ensemble model of alignment scoring

Tagashira, M.

10.1101/2022.04.27.489566 — bioinformatics — Posted on 2022-04-28

406 Projecting clumped transcriptomes onto single cell atlases to achieve single cell resolution

Johansen, N.; Quon, G.

10.1101/2022.04.26.489628 — bioinformatics — Posted on 2022-04-28

407 A methodology for co-simulation-based optimization of biofabrication protocols

Giannantoni, L.; Bardini, R.; Di Carlo, S.

10.1101/2022.01.28.478198 — bioinformatics — Posted on 2022-04-28

408 Benchmarking computational methods for B-cell receptor reconstruction from single-cell RNA-seq data

Andreani, T.; Slot, L.; Gabillard, S.; Struebing, C.; Reimertz, C.; Veeranagouda, Y.; Bakker, A.; Olfati-Saber, R.; Toes, R. E. M.; Auge, F.; Simaite, D.

10.1101/2022.03.24.485600 — bioinformatics — Posted on 2022-04-28

409 Algorithmic design of 3D wireframe RNA polyhedra

Elonen, A.; Natarajan, A. K.; Kawamata, I.; Oesinghaus, L.; Mohammed, A.; Seitsonen, J.; Suzuki, Y.; Simmel, F. C.; Kuzyk, A.; Orponen, P.

10.1101/2022.04.27.489653 — bioengineering — Posted on 2022-04-28

410 Cost-efficient boundary-free surface patterning achieves high effective-throughput of time-lapse microscopy experiments

Liang, G.; Yin, H.; Ding, F.

10.1101/2022.04.26.489629 — bioengineering — Posted on 2022-04-28

411 Museomic approaches to genotype historic Cinchona barks

Canales, N. A.; Gardner, E.; Walker, K.; Gress, T.; Bieker, V.; Martin, M. D.; Nesbitt, M.; Antonelli, A.; Ronsted, N.; Barnes, C.

10.1101/2022.04.26.489609 — genomics — Posted on 2022-04-28

412 happi: a Hierarchical Approach to Pangenomics Inference

Trinh, P.; Clausen, D. S.; Willis, A. D.

10.1101/2022.04.26.489591 — genomics — Posted on 2022-04-28

413 Novel trans-translation-associated gene regulation revealed by prophage excision-triggered switching of ribosome rescue pathway

Onodera, H.; Niwa, T.; Taguchi, H.; Chadani, Y.

10.1101/2022.04.27.489667 — genetics — Posted on 2022-04-28

414 Experimental evolution of a pheromone signal

Blankers, T.; Fruitet, E.; Burdfield-Steel, E.; Groot, A. T.

10.1101/2021.09.06.459111 — evolutionary biology — Posted on 2022-04-28

415 Toward Quantitative Metabarcoding

Shelton, A. O.; Gold, Z. J.; Jensen, A. J.; D'Agnese, E.; Allan, E. A.; Van Cise, A.; Gallego, R.; Ramon-Laca, A.; Garber-Yonts, M.; Parsons, K.; Kelly, R. P.

10.1101/2022.04.26.489602 — ecology — Posted on 2022-04-28

416 Which life history strategy can maintain high genetic diversity in plants?

Tsuzuki, Y.; Takada, T.; Ohara, M.

10.1101/2022.04.26.489613 — ecology — Posted on 2022-04-28

417 Digital whole-community phenotyping to assess morphological and physiological features of plant communities in the field

Zieschank, V.; Junker, R. R.

10.1101/2022.04.27.489638 — ecology — Posted on 2022-04-28

418 Isthmal stem cells sustain intestinal homeostasis and regeneration

Malagola, E.; Vasciaveo, A.; Ochiai, Y.; Kim, W.; Middelhoff, M.; Nienhuser, H.; Belin, B.; LaBella, J.; Zamechek, L.; Wong, M.; Li, L.; Guha, C.; Yan, K.; Califano, A.; Wang, T.

10.1101/2022.04.26.489611 — developmental biology — Posted on 2022-04-28

419 Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation

Tixi, W.; Maldonado, M.; Chang, Y.-T.; Parveen, N.; Chiu, A.; Hart, R. G.; Wang, S.; Hsu, W. J.; Kopp, J.; Huising, M.; Dhawan, S.; Shih, H.-P.

10.1101/2022.04.27.489466 — developmental biology — Posted on 2022-04-28

420 The Image Data Explorer: interactive exploration of image-derived data

Muller, C.; Serrano-Solano, B.; Sun, Y.; Tischer, C.; Heriche, J.-K.

10.1101/2022.04.27.489647 — cell biology — Posted on 2022-04-28

421 Dynamic Landscapes of tRNA Transcriptomes and Translatomes in Diverse Mouse Tissues

Yu, P.; Zhou, S.; Gao, Y.; Liang, Y.; Guo, W.; Wang, D. O.; Ding, S.; Lin, S.; Wang, J.; Cun, Y.

10.1101/2022.04.27.489644 — cell biology — Posted on 2022-04-28

422 Improved imaging and preservation of lysosome dynamics using silver nanoparticle-enhanced fluorescence

Soha, S. A.; Santhireswaran, A.; Hodgson, G. K.; Sugiyama, M.; Antonescu, C. N.; Impellizzeri, S.; Botelho, R.

10.1101/2022.04.26.489585 — cell biology — Posted on 2022-04-28

423 Correlative light and electron microscopy reveals fork-shaped structures at actin entry sites of focal adhesions

Legerstee, K.; Sueters, J.; Kremers, G.-J.; Hoogenboom, J. P.; Houtsmuller, A. B.

10.1101/2022.04.27.489664 — cell biology — Posted on 2022-04-28

424 The Toll and Imd pathway, the complement system and lectins during immune response of the nemertean Lineus ruber

Borve, A.; Orus-Alcalde, A.; Hejnol, A.

10.1101/2022.04.26.489627 — immunology — Posted on 2022-04-28

425 Testosterone eliminates strategic prosocial behavior

Kutlikova, H. H.; Zhang, L. H.; van Honk, J.; Lamm, C.

10.1101/2022.04.27.489681 — neuroscience — Posted on 2022-04-28

426 Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models

Zhao, Y.; Guo, T.; Pan, X.; Jiang, G.; Zhang, D.; Qi, J.; Shao, L.; Wang, Z.; Xu, H.

10.1101/2022.04.27.489696 — neuroscience — Posted on 2022-04-28

427 Blood-brain barrier dysfunction promotes astrocyte senescence through albumin-induced TGFβ signaling activation

Preininger, M.; Zaytseva, D.; Lin, J. M.; Kaufer, D.

10.1101/2022.04.25.489438 — neuroscience — Posted on 2022-04-28

428 Reversible and gain modulation of neuronal responses and sensorimotor behavior by mid-infrared stimulation

Xiao, T.; Wu, K.; Ding, Y.; Yang, X.; Chang, C.; Yang, Y.

10.1101/2022.04.27.489693 — neuroscience — Posted on 2022-04-28

429 Retinotopic organization of feedback projections in primate early visual cortex: implications for active vision

Wang, M.; Hou, Y.; Magrou, L.; Autio, J. A.; Misery, P.; Coalson, T.; Reid, E.; Xu, Y.; Lamy, C.; Falchier, A.; Zhang, Q.; Poo, M.-M.; Dehay, C.; Glasser, M. F.; Hayashi, T.; Knoblauch, K.; Van Essen, D.; Shen, Z.; Kennedy, H.

10.1101/2022.04.27.489651 — neuroscience — Posted on 2022-04-28

430 StandardRat: A multi-center consensus protocol to enhance functional connectivity specificity in the rat brain

Grandjean, J.; Desrosiers-Gregoire, G.; Anckaerts, C.; Angeles-Valdez, D.; Ayad, F.; Barriere, D. A.; Blockx, I.; Bortel, A. B.; Broadwater, M.; Cardoso, B. M.; Celestine, M.; Chavez-Negrete, J. E.; Choi, S.; Christiaen, E.; Clavijo, P.; Colon-Perez, L.; Cramer, S.; Daniele, T.; Dempsey, E.; Diao, Y.; Doelemeyer, A.; Dopfel, D.; Dvorakova, L.; Falfan-Melgoza, C.; Fernandes, F. F.; Fowler, C. F.; Fuentes-Ibanez, A.; Garin, C.; Gelderman, E.; Golden, C. E.; Guo, C. C.; Henckens, M. J.; Hennessy, L. A.; Herman, P.; Hofwijks, N.; Horien, C.; Ionescu, T. M.; Jones, J.; Kaesser, J.; Kim, E.; Lambers

10.1101/2022.04.27.489658 — neuroscience — Posted on 2022-04-28

431 Interplay between R2R3 MYB-type activators and repressors regulates proanthocyanidin biosynthesis in banana (Musa acuminata)

Rajput, R.; Naik, J.; Stracke, R.; Pandey, A.

10.1101/2022.04.27.489641 — plant biology — Posted on 2022-04-28

432 Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice

Mulcahy, M. C.; El Habbal, N.; Snyder, D.; Redd, J. R.; Sun, H.; Gregg, B. E.; Bridges, D.

10.1101/2022.04.27.489576 — physiology — Posted on 2022-04-28

433 Micro-CT analyses of the lung in mice: Parameters influencing the radiation dose and acquisition quality

Körner, S.; Körbel, C.; Dzierma, Y.; Speicher, K.; Laschke, M. W.; Rübe, C.; Menger, M. D.; Linxweiler, M.

10.1101/2022.04.27.489643 — biophysics — Posted on 2022-04-28

Spinelli, K.; Wei, C.; Vidali, L.; Wu, M.

10.1101/2022.04.26.489612 — biophysics — Posted on 2022-04-28

435 Decoding Surface Fingerprints for Protein-Ligand Interactions

Igashov, I.; Jamasb, A. R.; Sadek, A.; Sverrisson, F.; Schneuing, A.; Lio, P.; Blundell, T. L.; Bronstein, M.; Correia, B.

10.1101/2022.04.26.489341 — bioinformatics — Posted on 2022-04-28

436 Drug screening at single-organoid resolution via bioprinting and interferometry

Tebon, P. J.; Wang, B.; Markowitz, A. L.; Davarifar, A.; Krawczuk, P.; Murray, G.; Nguyen, H. T. L.; Tavanaie, N.; Nguyen, T. L.; Boutros, P. C.; Teitell, M. A.; Soragni, A.

10.1101/2021.10.03.462896 — bioengineering — Posted on 2022-04-27

437 Light diffusion in layered media: A numerical study in the spatial and time-domains

Helton, M.; Zerafa, S.; Vishwanath, K.; Mycek, M.-A.

10.1101/2022.04.26.489577 — bioengineering — Posted on 2022-04-28

438 Molecular docking, simulation and binding free energy analysis of small molecules as PfHT1 inhibitors

Owoloye, A. J.; Ligali, F.; Enejoh, O.; Musa, A.; Aina, O.; Idowu, E. T.; OYEBOLA, K.

10.1101/2022.04.27.489756 — bioinformatics — Posted on 2022-04-27

439 Population genetics reveals divergent lineages and ongoing hybridization in a declining migratory fish species complex

Rougemont, Q.; Perrier, C.; Besnard, A.-L.; Lebel, I.; Abdallah, Y.; Feunteun, E.; Reveillac, E.; Lasne, E.; Acou, A.; Nachon, D. J.; Cobo, F.; Evanno, G.; Bagliniere, J.-L.; Launey, S.

10.1101/2021.12.04.471201 — evolutionary biology — Posted on 2022-04-27

440 Estimation of the reference lead (Pb) concentration levels affecting immune cells in the blood of Black-headed Gulls (Chroicocephalus ridibundus, Laridae)

Ushine, N.; Kurata, O.; Tanaka, Y.; Nakayama, S. M. M.; Ishizuka, M.; Kato, T.; Hyama, S.-i.; Ushine N,Nakamura SMM, Ishizuka M, Tanaka Y, Kurata O, Kato T, Hayama S,

10.1101/2022.04.27.489755 — ecology — Posted on 2022-04-27

441 TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs

Eguchi, A.; Torres-Bigio, S. I.; Koleckar, K.; Gonzalez, A. F. G. S.; Birnbaum, F.; Blau, H. M.

10.1101/2022.01.10.475653 — cell biology — Posted on 2022-04-27

442 Neural Implementation of Precise Temporal Patterns in Motor Cortex

Ning, Y.; Zheng, T.; Wan, G.; Han, J.; Liu, T.; Zhang, S.

10.1101/2022.04.27.489682 — neuroscience — Posted on 2022-04-27

443 Whole-brain dynamics of human sensorimotor adaptation

Standage, D. I.; Areshenkoff, C. N.; Gale, D. J.; Nashed, J. Y.; Flanagan, J. R.; Gallivan, J. P.

10.1101/2020.11.27.401679 — neuroscience — Posted on 2022-04-27

444 Explainable Machine Learning Approach to Predict and Explain the Relationship between Task-based fMRI and Individual Differences in Cognition

Pornpattananangkul, N.; Wang, Y.; Bartonicek, A.; Candia, J.; Stringaris, A.

10.1101/2020.10.21.348367 — neuroscience — Posted on 2022-04-27

445 Dissociable plasticity of the nucleus basalis of Meynert in early and late blind individuals

Bang, J. W.; Chan, R. W.; Parra, C.; Murphy, M. C.; Schuman, J. S.; Nau, A. C.; Chan, K. C.

10.1101/2021.08.18.456825 — neuroscience — Posted on 2022-04-27

446 Dynamic neural reconstructions of attended object location and features using EEG

Chen, J.; Golomb, J. D.

10.1101/2022.04.26.489558 — neuroscience — Posted on 2022-04-27

447 Bone marrow haematopoietic stem cells influence liver homeostatic networks and cancer development

Alipour Talash, G.; Langfelder, P.; Vitale, D.; Karimi Azardaryany, M.; Belgard, T. G.; Choo, J.; Rogers, G.; Ho, V.; Ramezani-Moghadam, M.; Dervish, S.; Lai, J.; Gloss, B. S.; McLeod, D.; Eslam, M.; Liddle, C.; Qiao, L.; George, J.; Esmaili, S.

10.1101/2022.04.16.488543 — systems biology — Posted on 2022-04-27

448 Assessment of local potato cultivars found in Cis-Himalayan region of West Bengal through morphology and biochemical profiling

Dutta, S.; Chakraborty, S.; Reddy, B. J.; Nag, S.; Nath, S.; Routh, S.; Behera, V.; Lazar, G. J.; Monika, B.; Hijam, L.; Chakraborty, M.; Roy, S. K.; Choudhury, A.; Hembram, S.; Debnath, M. K.; Mandal, R.

10.1101/2022.04.27.489635 — plant biology — Posted on 2022-04-27

449 Sequence-structure-function relationships in the microbial protein universe

Koehler Leman, J.; Szczerbiak, P.; Renfrew, P. D.; Gligorijevic, V.; Berenberg, D.; Vatanen, T.; Taylor, B. C.; Chandler, C.; Janssen, S.; Carriero, N.; Fisk, I.; Xavier, R. J.; Knight, R.; Bonneau, R.; Kosciolek, T.

10.1101/2022.03.18.484903 — bioinformatics — Posted on 2022-04-27

450 Paradoxical decrease of imitation performance with age in children

Ottoboni, G.; Toraldo, A.; Proietti, R.; Cangelosi, A.; Tessari, A.

10.1101/2022.04.27.489190 — animal behavior and cognition — Posted on 2022-04-27

451 Diversity and abundance of archaeal amoA genes in the permanent and temporary oxygen minimum zones of Indian Ocean.

PrasannaKumar, C.; Elamaran, A.

10.1101/2022.04.27.489739 — molecular biology — Posted on 2022-04-27

452 Generation of Gausemycin A-resistant Staphylococcus aureus

Vasilchenko, A. S.; Poshvina, D.; Dilbaryan, D. S.; Sadykova, V. S.; Rogozhin, E. A.; Kasyanov, S. P.; Lapchinskaya, O. A.

10.1101/2022.04.26.489521 — microbiology — Posted on 2022-04-27

453 Selection of software and database for metagenomics sequence analysis impacts the outcome of microbial profiling and pathogen detection

Xu, R.; Salvador, L.; Sreekumari Rajeev, S.

10.1101/2022.04.27.489679 — microbiology — Posted on 2022-04-27

454 Humanization and Expression of IgG and IgM Antibodies in Plants as Potential Diagnostic Reagents for Valley Fever

Jugler, C.; Grill, F. J.; Lake, D. F.; Chen, Q.

10.1101/2022.04.27.489777 — immunology — Posted on 2022-04-27

455 Resource allocation accounts for the large variabilityof rate-yield phenotypes across bacterial strains

Baldazzi, V.; Ropers, D.; Gouze, J.-L.; Gedeon, T.; de Jong, H.

10.1101/2022.04.27.489666 — systems biology — Posted on 2022-04-27

456 Computational analysis of 4-1BB-induced NF κB signaling suggests improvements to CAR cell design

Tserunyan, V.; Finley, S. D.

10.1101/2022.04.27.489659 — systems biology — Posted on 2022-04-27

457 T32 training is associated with increased likelihood of obtaining an academic research faculty position: a cross-sectional study

Mueller, A.; Schnirel, A. A.; Kleppner, S.; Tsao, P.; Leeper, N.

10.1101/2022.04.27.489715 — scientific communication and education — Posted on 2022-04-27

458 Integrative human atrial modeling unravels interactive PKA and CaMKII signaling as key determinant of atrial arrhythmogenesis

Ni, H.; Morotti, S.; Zhang, X.; Dobrev, D.; Grandi, E.

10.1101/2022.04.27.489795 — physiology — Posted on 2022-04-27

459 Fic-mediated AMPylation tempers the Unfolded Protein Response during physiological stress

Casey, A. K.; Gray, H. F.; Chimalapati, S.; Hernandez, G.; Moehlman, A.; Stewart, N.; Fields, H. A.; Gulen, B.; Servage, K. A.; Stefanius, K.; Blevins, A.; Daoud, E.; Evers, B. M.; Kramer, H.; Orth, K.

10.1101/2022.04.27.489443 — physiology — Posted on 2022-04-27

460 Loss of Myosin-1e biases MMTV-PyMT induced breast cancer towards a 4 differentiated and secretory state

Plante, E. L.; Chase, S. E.; De Jong, E. P.; Curtis, T. M.; Garone, M. E.; Krendel, M.

10.1101/2022.04.27.489205 — cancer biology — Posted on 2022-04-27

461 Biomolecular condensates govern PARP inhibitor trapping and present mechanisms of resistance

Gopal, A. A.; Fernandez, B.; Delano, J.; Weissleder, R.; Dubach, J. M.

10.1101/2022.04.27.489674 — biophysics — Posted on 2022-04-27

462 Pericytes and Astrocytes Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche Model

Ngo, M. T.; Sarkaria, J. N.; Harley, B.

10.1101/2022.04.27.489740 — bioengineering — Posted on 2022-04-27

463 A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage

Lau, R. K.; Enustun, E.; Gu, Y.; Nguyen, J. V.; Corbett, K. D.

10.1101/2022.04.27.489752 — biochemistry — Posted on 2022-04-27

464 Computationally Guided Design of Novel Angiotensin Converting Enzyme Inhibitors

Lam, J. D.; Riley, M.; Siegel, J. B.

10.1101/2022.04.27.489637 — biochemistry — Posted on 2022-04-27

465 Inhibiting succinate release worsens cardiac reperfusion injury by enhancing mitochondrial reactive oxygen species generation

Milliken, A. S.; Nadtochiy, S. M.; Brookes, P. S.

10.1101/2022.04.27.489760 — biochemistry — Posted on 2022-04-27

466 Cocoa Extract Exerts Sex-Specific Effects in an Aggressive Hyperglycemia Model: A Pilot Study

Racine, K. C.; Iglesias-carres, L.; Herring, J.; Ferruzzi, M.; Kay, C.; Tessem, J.; Neilson, A. P.

10.1101/2022.04.27.489764 — biochemistry — Posted on 2022-04-27

467 Mutation rates and adaptive variation among the clinically dominant clusters of Mycobacterium abscessus

Commins, N.; Sullivan, M. R.; McGowen, K.; Koch, E.; Rubin, E. J.; Farhat, M.

10.1101/2022.04.27.489597 — genomics — Posted on 2022-04-27

468 CLASP1 is essential for neonatal lung function and survival in mice

Pereira, A. L.; da Silva, T. F.; Ferreira, L. T.; Jaegle, M.; Buscop-van Kempen, M.; Rottier, R.; van Ijcken, W. F. J.; Brites, P.; Galjart, N.; Maiato, H.

10.1101/2022.04.27.489792 — developmental biology — Posted on 2022-04-27

469 Functional genomics analysis identifies impairment of HNF1B function as a cause of Mayer-Rokitansky-Küster-Hauser syndrome.

Thomson, E.; Tran, M.; Robevska, G.; Ayers, K.; Gopalakrishnan Bhaskaran, P.; Haan, E.; Cereghini, S.; Vash-Margita, A.; Margetts, M.; Hensley, A.; Nguyen, Q.; Sinclair, A.; Koopman, P.; Pelosi, E.

10.1101/2022.04.26.489616 — developmental biology — Posted on 2022-04-27

470 Mediator-RNA Polymerase II Interactions Critical for Transcriptional Activation Are Mediated by the N-terminal Half of MED14 and C-terminal Domain of RPB1

Baris, Y.; Jabbar, J.; Yozgat, Y.; Cigirgan, E.; Bay, S.; Erden Tucer, M.; Aslan, V.; Dinccelik-Aslan, M.; Cevher, M. A.

10.1101/2022.04.27.489650 — molecular biology — Posted on 2022-04-27

471 Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain

Hay, I. M.; Mulholland, K. E.; Graham, S. C.; Sharpe, H.; Deane, J. E.

10.1101/2022.04.27.489754 — molecular biology — Posted on 2022-04-27

472 The conserved histone chaperone Spt6 facilitates DNA replication and mediates genome instability

Miller, C. L. W.; Winston, F.

10.1101/2022.04.27.489770 — molecular biology — Posted on 2022-04-27

473 P681 mutations within the polybasic motif of spike dictate fusogenicity and syncytia formation of SARS CoV-2 variants

Kuzmina, A.; Atari, N.; Ottolenghi, A.; Korovin, D.; Cohen Lass, I.; Rosental, B.; Rosenberg, E.; Mandelboim, M.; Taube, R.

10.1101/2022.04.26.489630 — microbiology — Posted on 2022-04-27

474 Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

Liu, Z.; Li, L.; Xu, W.; Yuan, Y.; Liang, X.; Zhang, L.; Wei, Z.; Sui, L.; Zhao, Y.; Cui, Y.; Yin, Q.; Li, D.; Li, Q.; Wei, F.; Hou, Z.; Liu, Q.; Wang, Z.

10.1101/2022.04.27.489762 — microbiology — Posted on 2022-04-27

475 Analysis of Aedes aegypti microRNAs in response to Wolbachia wAlbB infection and their potential role in mosquito longevity

Bishop, C. R.; Hussain, M.; Hugo, L.; Asgari, S.

10.1101/2022.04.26.488845 — microbiology — Posted on 2022-04-27

476 Coupling of NOD2 to GIV is Required for Bacterial Sensing

Katkar, G. D.; Anandachar, M. S.; Sinha, S.; Ibeawuchi, S.-R.; Espinoza, C. R.; Coates, J.; Malhotra, Y. S.; Mullick, M.; Castillo, V.; Vo, D. T.; Sahoo, D.; Ghosh, P.

10.1101/2022.04.26.489574 — immunology — Posted on 2022-04-27

477 A role for the circadian transcription factor NPAS2 in the progressive loss of non-rapid eye movement sleep and increased arousal during fentanyl withdrawal in male mice

Gamble, M. C.; Chuan, B.; Gallego-Martin, T.; Shelton, M. A.; Puig, S.; O'Donnell, C. P.; Logan, R. W.

10.1101/2022.04.27.489767 — neuroscience — Posted on 2022-04-27

478 The double round-robin population unravels the genetic architecture of grain size in barley

Shrestha, A.; Cosenza, F.; Inghelandt, D. v.; Wu, P.-Y.; Li, J.; Casale, F.; Weisweiler, M.; Stich, B.

10.1101/2022.04.26.489546 — plant biology — Posted on 2022-04-27

479 Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2

Loschwitz, J.; Wang, X.; Strodel, B.

10.1101/2022.04.27.489784 — biophysics — Posted on 2022-04-27

480 BioNE: Integration of network embeddings for supervised learning

Parvizi, P.; Azuaje, F.; Theodoratou, E.; Luz, S.

10.1101/2022.04.26.489560 — bioinformatics — Posted on 2022-04-27

481 Dynamic Features of Chromosomal Instability during Culture of Induced Pluripotent Stem Cells

Dubose, C. O.; Daum, J. R.; Sansam, C. L.; Gorbsky, G. J.

10.1101/2022.04.26.489564 — cell biology — Posted on 2022-04-27

482 Dynamic neural reconstructions of attended object location and features using EEG

Chen, J.; Golomb, J. D.

10.1101/2022.04.26.489558 — neuroscience — Posted on 2022-04-27

483 Mechanisms regulating the frequency of inhibition-based gamma oscillations in primate prefrontal and parietal cortices

Gonzalez-Burgos, G.; Miyamae, T.; Reddy, N.; Dawkins, S.; Chen, C.; Hill, A.; Enwright, J. F.; Ermentrout, G. B.; Lewis, D. A.

10.1101/2022.04.26.489470 — neuroscience — Posted on 2022-04-27

484 Neurofeedback training for improving motor performance in healthy adults: A systematic review and meta-analysis

Onagawa, R.; Muraoka, Y.; Hagura, N.; Takemi, M.

10.1101/2022.04.26.487963 — neuroscience — Posted on 2022-04-27

485 Episodic memory retrieval affects the onset and dynamics of evidence accumulation during value-based decisions

Kraemer, P. M.; Gluth, S.

10.1101/2022.04.26.489332 — neuroscience — Posted on 2022-04-27

486 Fixational eye movements as active sensation for high visual acuity

Nghiem, T.-A. E.; Dufour, O.; Reiniger, J. L.; Harmening, W. M.; Azeredo da Silveira, R.

10.1101/2022.04.26.489583 — neuroscience — Posted on 2022-04-27

487 Aquaporin 4 is differentially increased and depolarized in association with tau and amyloid-beta

Kecheliev, V.; Boss, L.; Maheshwari, U.; Konietzko, U.; Keller, A.; Razansky, D.; Nitsch, R. M.; Klohs, J.; Ni, R.

10.1101/2022.04.26.489273 — neuroscience — Posted on 2022-04-27

488 Cortical response variability is driven by local excitability changes with somatotopic organization

Stephani, T.; Nierula, B.; Villringer, A.; Eippert, F.; Nikulin, V. V.

10.1101/2022.04.26.489557 — neuroscience — Posted on 2022-04-27

489 Efficacy and Specificity of Melanopsin Reporters for Retinal Ganglion Cells

Maloney, R. T.; Quattrochi, L.; Yoon, J. S.; Souza, R.; Berson, D. M.

10.1101/2022.04.26.489554 — neuroscience — Posted on 2022-04-27

490 The arthropod associates of 155 North American cynipid oak galls

Ward, A. K. G.; Busbee, R. W.; Chen, R. A.; Davis, C. K.; Driscoe, A. L.; Egan, S. P.; Goldberg, B. A.; Hood, G. R.; Jones, D.; Kranz, A. J.; Meadley-Dunphy, S. A.; Milks, A. K.; Ott, J. R.; Prior, K. M.; Sheikh, S. I.; Shzu, S.; Weinersmith, K. L.; Zhang, L.; Zhang, Y. M.; Forbes, A. A.

10.1101/2022.04.26.489445 — zoology — Posted on 2022-04-27

491 Approximating Solutions of the Chemical Master Equation using Neural Networks

Sukys, A.; Öcal, K.; Grima, R.

10.1101/2022.04.26.489548 — systems biology — Posted on 2022-04-27

492 Inflammation as a Silent Partner in Opioid Addiction: A Regulatory Logic Model

Toole, J. T.; Morris, M. C.; Lyman, C. A.; Spink, G.; Broderick, G.

10.1101/2022.04.26.489572 — systems biology — Posted on 2022-04-27

493 Robustness of organ morphology is associated with modules of co-expressed genes related to plant cell wall

Hartasanchez, D. A.; Kiss, A. K.; Battu, V.; Dumond, M.; Soraru, C.; Delgado Vaquera, A.; Massinon, F.; Braso-Vives, M.; Mollier, C.; Dubrulle, N.; Senechal, F.; Martin-Magnette, M.-L.; Boudaoud, A.; Moneger, F.

10.1101/2022.04.26.489498 — plant biology — Posted on 2022-04-27

494 MycoPhylo experiment reveals how mycorrhiza types and phylogenetic relationships affect soil biodiversity and functioning

Tedersoo, L.; Loit, K.; Agan, A.; Rahimlou, S.; Vask, A.; Drenkhan, R.

10.1101/2022.04.26.489578 — plant biology — Posted on 2022-04-27

495 Discovery of new senolytics using machine learning

Smer-Barreto, V.; Quintanilla, A.; Elliot, R. J.; Dawson, J. C.; Sun, J.; Carragher, N.; Acosta, J. C.; Oyarzun, D. A.

10.1101/2022.04.26.489505 — cancer biology — Posted on 2022-04-27

496 Elevated arginine levels in liver tumors promote metabolic reprogramming and tumor growth

Mossmann, D.; Park, S.; Ryback, B.; Weissenberger, D.; Colombi, M.; Hindupur, S. K.; Dazert, E.; Coto-Llerena, M.; Caner, E.; Cenzano, V. J.; Piscuoglio, S.; Bosch, F.; Terracciano, L. M.; Sauer, U.; Hall, M. N.

10.1101/2022.04.26.489545 — cancer biology — Posted on 2022-04-27

497 Prediction of allosterically acting mutations using MD simulations and Rosetta

Wells, N. G. M.; Smith, C. A.

10.1101/2022.04.26.489494 — biophysics — Posted on 2022-04-27

498 Faster SARS-CoV-2 sequence validation and annotation for GenBank using VADR

Nawrocki, E. P.

10.1101/2022.04.25.489427 — bioinformatics — Posted on 2022-04-27

499 A Comparison of Dimension Reduction Methods for Cytometry by Time-of-Flight Data

Wang, K.; Yang, Y.; Wu, F.; Song, B.; Wang, X.; Wang, T.

10.1101/2022.04.26.489549 — bioinformatics — Posted on 2022-04-27

500 Relationships between post-stroke mediolateral stepping characteristics, walking speed, balance performance, and balance confidence

Howard, K. E.; Reimold, N. K.; Knight, H. L.; Embry, A. E.; Chesnutt, A. N.; Knapp, H. A.; Henderson, R. E.; Agne, A. A.; Jacobs, C. J.; Dean, J. C.

10.1101/2022.04.26.489530 — bioengineering — Posted on 2022-04-27

501 Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis

Gegner, H. M.; Naake, T.; Dugourd, A.; Mueller, T.; Czernilofsky, F.; Kliewer, G.; Jaeger, E.; Helm, B.; Kunze-Rohrbach, N.; Klingmueller, U.; Hopf, C.; Mueller-Tidow, C.; Dietrich, S.; Saez-Rodriguez, J.; Huber, W.; Hell, R.; Poschet, G.; Krijgsveld, J.

10.1101/2022.04.26.489520 — biochemistry — Posted on 2022-04-27

502 Enhanced recovery of single-cell RNA-sequencing reads for missing gene expression data

Pool, A.-H.; Poldsam, H.; Chen, S.; Thomson, M.; Oka, Y.

10.1101/2022.04.26.489449 — genomics — Posted on 2022-04-27

503 The rediscovery of a relict unlocks the first global phylogeny of whip spiders (Amblypygi)

de Miranda, G. S.; Kulkarni, S. S.; Tagliatela, J.; Baker, C. M.; Giupponi, A. P. L.; Labarque, F. M.; Gavish Regev, E.; Rix, M. G.; Carvalho, L. S.; Fusari, L. M.; Wood, H. M.; Sharma, P. P.

10.1101/2022.04.26.489547 — genomics — Posted on 2022-04-27

504 Differentiation of thermal reaction norms between marginal and core populations of a northward expanding parasitoid

Delava, E.; Fleury, F.; Gibert, P.

10.1101/2022.04.26.489532 — evolutionary biology — Posted on 2022-04-27

505 Extensive protected area coverage and an updated global population estimate for the Endangered Madagascar Serpent-eagle identified from species-habitat associations using remote sensing data

Sutton, L. J.; Benjara, A.; Rene de Roland, L.-A.; Thorstrom, R.; McClure, C. J.

10.1101/2022.04.26.489510 — ecology — Posted on 2022-04-27

506 Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits

Isakoglou, C.; Haak, K. V.; Wolfers, T.; Floris, D. L.; Llera, A.; Oldehinkel, M.; Forde, N. J.; Oakley, B. F. M.; Tillmann, J.; Holt, R. J.; Moessnang, C.; Loth, E.; Bourgeron, T.; Baron-Cohen, S.; Charman, T.; Banaschewski, T.; Murphy, D. G. M.; Buitelaar, J. K.; Marquand, A. F.; Beckmann, C. F.; EU-AIMS LEAP Group,

10.1101/2022.04.26.489525 — neuroscience — Posted on 2022-04-27

507 Aperiodic brain activity and response to anesthesia vary in disorders of consciousness

Maschke, C.; Duclos, C.; Owen, A. M.; Jerbi, K.; Blain-Moraes, S.

10.1101/2022.04.22.489199 — neuroscience — Posted on 2022-04-27

508 Dietary fatty acids modulate the endocannabinoid system in rat submandibular gland

Combina Herrera, C. N.; Blanco, M.; Repossi, G.; Escandriolo Nackauzi, J. D.; Actis, A. B.

10.1101/2022.04.25.489419 — pathology — Posted on 2022-04-27

509 Assessment of Culicidae collection methods for xenomonitoring lymphatic filariasis in malaria co-infection context in Burkina Faso

Coulibaly, S.; Sawadogo, S. P.; Nikiema, A. S.; Hien, A. S.; Bamogo, R.; Koala, L.; Sangare, I.; Bougma, R. W.; Koudou, B. B.; Fournet, F.; Ouedraogo, G. A.; Dabire, R. K.

10.1101/2022.04.26.489492 — pathology — Posted on 2022-04-27

510 Genomic And Molecular Characterization Of The Wheat Streak Mosaic Virus Resistance Locus 2 (Wsm2) In Common Wheat (Triticum Aestivum. L)

Xie, Y.; Nachappa, P.; Nalam, V.; Pearce, S.

10.1101/2022.04.26.489503 — pathology — Posted on 2022-04-27

511 Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

Diamond, B. T.; Ziccheddu, B.; Maclachlan, K. H.; Taylor, J.; Boyle, E.; Arrango Ossa, J.; Jahn, J. T.; Affer, M.; Totiger, T. M.; Coffey, D. G.; Watts, J.; Lu, S. X.; Bolli, N.; Bolton, K.; Park, J. H.; Landau, H.; Ganesh, K.; McPherson, A.; Sekeres, M.; Lesokhin, A.; Chung, D.; Zhang, Y.; Ho, C.; Roshal, M.; Tyner, J.; Nimer, S.; Papaemmanuil, E.; Usmani, S.; Morgan, G.; Landgren, O.; Maura, F.

10.1101/2022.04.26.489507 — cancer biology — Posted on 2022-04-27

512 Utilising hippocampal neuronal calcium activity in mouse CA1 for a multimodal optical brain-computer interface

Sun, D.; Saatlou, F. H.; Yu, Y.; Unnithan, R. R.; French, C.

10.1101/2022.04.26.489497 — bioengineering — Posted on 2022-04-27

513 Weak seed banks influence the signature and detectability of selective sweeps

Korfmann, K.; Abu Awad, D.; Tellier, A.

10.1101/2022.04.26.489499 — evolutionary biology — Posted on 2022-04-27

514 Microglia reactivity entails microtubule remodeling from acentrosomal to centrosomal arrays

Rosito, M.; Sanchini, C.; Gosti, G.; Moreno, M.; De Panfilis, S.; Giubettini, M.; Debellis, D.; Catalano, F.; Peruzzi, G.; Marotta, R.; Indrieri, A.; De Leonibus, E.; De Stefano, M. E.; Ragozzino, D.; Ruocco, G.; Di Angelantonio, S.; Bartolini, F.

10.1101/2022.02.21.481355 — cell biology — Posted on 2022-04-27

515 Molecular transport and packing underlie increasing ribosome productivity in faster growing cells

Maheshwari, A. J.; Sunol, A. M.; Gonzalez, E.; Endy, D.; Zia, R. N.

10.1101/2021.10.27.466129 — biophysics — Posted on 2022-04-27

516 Population bottlenecks constrain host microbiome diversity and genetic variation impeding fitness

Orsted, M.; Yashiro, E.; Hoffmann, A. A.; Kristensen, T. N.

10.1101/2021.07.04.450854 — evolutionary biology — Posted on 2022-04-27

517 Early dosage compensation of zygotically-expressed genes in Drosophila melanogaster is mediated through a post-transcriptional regulatory mechanism

Blake, V. M.; Eisen, M.

10.1101/2022.04.25.489409 — molecular biology — Posted on 2022-04-27

518 Brainstem speech encoding is dynamically shaped online by fluctuations in cortical α state

Lai, J.; Price, C. N.; Bidelman, G. M.

10.1101/2022.04.11.487894 — neuroscience — Posted on 2022-04-27

519 Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

Somaiya, R. D.; Stebbins, K.; Xie, H.; Garcia, A. D. R.; Fox, M.

10.1101/2022.02.22.481508 — neuroscience — Posted on 2022-04-27

520 Relationships between individual differences in dual process and electrophysiological signatures of familiarity and recollection during retrieval

Dimsdale-Zucker, H. R.; Maciejewska, K.; Kim, K.; Yonelinas, A. P.; Ranganath, C.

10.1101/2021.09.15.460509 — neuroscience — Posted on 2022-04-27

521 Targeting Neutrophils Extracellular Traps (NETs) reduces multiple organ injury in a COVID-19 mouse model

Veras, F. P.; Gomes, G. F.; Silva, B. M.; Almeida, C.; Silva, C. M.; Schneider, A. H.; Corneo, E. S.; Bonilha, C. S.; Batah, S. S.; Martins, R. P.; Arruda, E.; Fabro, A. T.; Alves-Filho, J. C. A.; Cunha, T. M.; Cunha, F. Q.

10.1101/2022.04.27.489676 — pharmacology and toxicology — Posted on 2022-04-27

522 Staphylococcus aureus prophages are gatekeepers of lipid utilization to control membrane flexibility, bacterial fitness, and antibiotic adaptation

Gloux, K.; Zhou, B.; Pathania, A.; Pant, D.; Gaudu, P.; Trieu-Cuot, P.; Gruss, A.; halpern, d.

10.1101/2022.01.27.478126 — microbiology — Posted on 2022-04-27

523 Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

Wall, M.; Hill, E.; Huckstepp, R.; Barkan, K.; Deganutti, G.; Leuenberger, M.; Preti, B.; Winfield, I.; Carvalho, S.; Suchankova, A.; Wei, H.; Safitri, D.; Huang, X.; Imlach, W.; La Mache, C.; Dean, E.; Hume, C.; Hayward, S.; Oliver, J.; Zhao, F.-Y.; Spanswick, D.; Reynolds, C. A.; Lochner, M.; Ladds, G.; Frenguelli, B.

10.1101/2020.04.04.023945 — physiology — Posted on 2022-04-27

524 Characterization of peptide-protein relationships in protein ambiguity groups via bipartite graphs

Schork, K.; Turewicz, M.; Uszkoreit, J.; Rahnenführer, J.; Eisenacher, M.

10.1101/2021.07.28.454128 — bioinformatics — Posted on 2022-04-27

525 QTLViewer: An interactive webtool for genetic analysis in the Collaborative Cross and Diversity Outbred mouse populations

Vincent, M.; Gerdes Gyuricza, I.; Keele, G. R.; Gatti, D. M.; Keller, M. P.; Broman, K. W.; Churchill, G. A.

10.1101/2022.03.15.484471 — bioinformatics — Posted on 2022-04-27

526 Multiple origins of nematode-Wolbachia symbiosis in supergroup F and convergent loss of bacterioferritin in filarial Wolbachia

Sinha, A.; Li, Z.; Poole, C. B.; Ettwiller, L.; Lima, N. F.; Ferreira, M. U.; Fombad, F. F.; Wanji, S.; Carlow, C.

10.1101/2021.03.23.436630 — genomics — Posted on 2022-04-27

527 Genome editing excisase origins illuminated by somatic genome of Blepharisma

Singh, M.; Seah, B. K. B.; Emmerich, C.; Singh, A.; Woehle, C.; Huettel, B.; Byerly, A.; Stover, N. A.; Sugiura, M.; Harumoto, T.; Swart, E. C.

10.1101/2021.12.14.471607 — genomics — Posted on 2022-04-27

528 The molecular architecture of cell cycle arrest

Stallaert, W.; Taylor, S. R.; Kedziora, K. M.; Johnson, M. S.; Taylor, C. D.; Sobon, H. K.; Young, C. L.; Limas, J. C.; Varblow Holloway, J.; Cook, J. G.; Purvis, J. E.

10.1101/2022.04.27.489684 — cell biology — Posted on 2022-04-27

529 Brain dysfunction during warming is caused by oxygen limitation in larval zebrafish

Andreassen, A. H.; Hall, P.; Khatibzadeh, P.; Jutfelt, F.; Kermen, F.

10.1101/2020.12.28.424529 — neuroscience — Posted on 2022-04-27

530 Real-time monitoring of endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation

Harish, R. K.; Gupta, M.; Zoller, D.; Hartmann, H.; Gheisari, A.; Machate, A.; Hans, S.; Brand, M.

10.1101/2022.04.26.488902 — developmental biology — Posted on 2022-04-27

531 Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

Riquelme-Guzman, C.; Tsai, S. L.; Carreon Paz, K.; Nguyen, C.; Oriola, D.; Schuez, M.; Brugues, J.; Currie, J. D.; Sandoval-Guzman, T.

10.1101/2022.04.27.489662 — developmental biology — Posted on 2022-04-27

532 Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons

Rhymes, E. R.; Tosolini, A. P.; Fellows, A. D.; Mahy, W.; McDonald, N. Q.; Schiavo, G.

10.1101/2022.04.26.489550 — neuroscience — Posted on 2022-04-27

533 Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse

Seehusen, F.; Clark, J. J.; Sharma, P.; Bentley, E.; Kirby, A.; Subramaniam, K.; Wunderlin Giuliani, S.; Hughes, G.; Patterson, E. I.; Michael, B. D.; Owen, A.; Hiscox, J. A.; Stewart, J. P.; Kipar, A.

10.1101/2021.04.16.440173 — pathology — Posted on 2022-04-27

534 A mitochondria-specific mutational signature of aging: increased rate of A>G substitutions on a heavy chain.

Mikhailova, A. G.; Mikhailova, A. A.; Ushakova, K.; Tretiakov, E.; Iliushchenko, D.; Shamanskiy, V. A.; Iurchenko, A.; Zazhytska, M.; Kozenkova, E.; Zdobnov, E. M.; Makeev, V.; Yurov, V.; Tanaka, M.; Gostimskaya, I.; Fleischmann, Z. M.; Annis, S.; Franco, M.; Wasko, K.; Kunz, W.; Knorre, D.; Mazunin, I.; Nikolaev, S.; Fellay, J.; Reymond, A.; Khrapko, K.; Gunbin, K.; Popadin, K.

10.1101/2021.12.03.460832 — bioinformatics — Posted on 2022-04-27

535 Optimized Repli-seq: Improved DNA Replication Timing Analysis by Next-Generation Sequencing

Rivera-Mulia, J. C.; Trevilla-Garcia, C.; Martinez-Cifuentes, S.

10.1101/2022.04.26.489601 — genomics — Posted on 2022-04-27

536 Systems analysis of metabolic responses to a mixed meal test in an obese cohort reveals links between tissue metabolism and the gut microbiota

Li, P.; Ji, B.; Lappa, D.; Meijnikman, A. S.; Olsson, L. M.; Aydin, O.; Bruin, S. C.; Laar, A. v. d.; Tremaroli, V.; Luo, H.; Geng, J.; Krautkramer, K. A.; Lundqvist, A.; Herrema, H.; Groen, A. K.; Gerdes, V. E. A.; Schwartz, T. W.; Backhed, F.; Nieuwdorp, M.; Olofsson, L. E.; Nielsen, J.

10.1101/2022.04.26.489057 — systems biology — Posted on 2022-04-27

537 Integrated molecular analysis reveals two distinct subtypes of pure seminoma of the testis

Medvedev, K. E.; Savelyeva, A. V.; Bagrodia, A.; Jia, L.; Grishin, N. V.

10.1101/2022.04.25.489437 — cancer biology — Posted on 2022-04-27

538 Identifying targetable metabolic dependencies across colorectal cancer progression

Legge, D. N.; Holt, A. K.; Bull, C. J.; Collard, T. J.; Kollareddy, M.; Bellamy, J.; Groves, S.; Ma, E. H.; Hazelwood, E.; Qualtrough, D.; Amulic, B.; Malik, K. N.; Williams, A. C.; Jones, N.; Vincent, E. E.

10.1101/2022.03.23.485483 — cancer biology — Posted on 2022-04-27

539 Joint structural annotation of small molecules using liquid chromatography retention order and tandem mass spectrometry data

Bach, E.; Schymanski, E.; Rousu, J.

10.1101/2022.02.11.480137 — bioinformatics — Posted on 2022-04-27

540 Nanoscale ligand density modulates gap junction intercellular communication of cell condensates during chondrogenesis

Casanellas, I.; Lagunas, A.; Vida, Y.; Perez-Inestrosa, E.; Rodriguez-Pereira, C.; Magalhaes, J.; Andrades, J. A.; Becerra, J.; Samitier, J.

10.1101/2021.04.28.441739 — bioengineering — Posted on 2022-04-27

541 Infection signaling and antimicrobial wound care in an ant society

Frank, E. T.; Kesner, L.; Liberti, J.; Helleu, Q.; LeBoeuf, A.; Dascalu, A.; Azuma, F.; Economo, E.; Waridel, P.; Engel, P.; Schmitt, T.; Keller, L.

10.1101/2022.04.26.489514 — animal behavior and cognition — Posted on 2022-04-27

542 Canine lineages reveal genetic drivers of dog behavioral diversification

Dutrow, E. V.; Serpell, J. A.; Ostrander, E. A.

10.1101/2022.04.26.489536 — genomics — Posted on 2022-04-27

543 Widespread allele-specific topological domains in the human genome are not confined to imprinted gene clusters.

Richer, S.; Yuan, T.; Schoenfelder, S.; Hurst, L.; Murrell, A.; Pisignano, G.

10.1101/2022.04.26.489502 — genomics — Posted on 2022-04-27

544 Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis

Mantri, M.; Hinchman, M. M.; McKellar, D. W.; Wang, M. F. Z.; Cross, S. T.; Parker, J. S. L.; De Vlaminck, I.

10.1101/2021.12.07.471659 — genomics — Posted on 2022-04-27

545 Hydrothermal sulphur bacteria enhance mercury availability for coastal marine organisms

Ruiz, E.; Lacoue-Labarthe, T.; Brault-Favrou, M.; Pascal, P.-Y.

10.1101/2022.04.26.489323 — ecology — Posted on 2022-04-27

546 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg fusion

Lu, Y.; Shimada, K.; Zhang, J.; Ogawa, Y.; Tang, S.; Noda, T.; Shibuya, H.; Ikawa, M.

10.1101/2022.04.15.488448 — developmental biology — Posted on 2022-04-27

547 Single cell RNA-seq identifies inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma

Chen, L.; Hoefel, G. A.; Pathinayake, P. S.; Reid, A.; Kelly, C.; HuiYing, T.; Kim, R. Y.; Hansbro, P. M.; Brody, S. L.; Foster, P. S.; Horvat, J. C.; Riveros, C.; Wark, P. A.; Kaiko, G. E.

10.1101/2022.04.26.489055 — cell biology — Posted on 2022-04-27

548 Comparison of biological features of wild European rabbit mesenchymal stem cells derived from different tissues.

Calle, A.; Zamora-Ceballos, M.; Barcena, J.; Blanco, E.; Ramirez, M. A.

10.1101/2021.12.13.472420 — cell biology — Posted on 2022-04-27

549 Survivin prevents the Polycomb Repressor Complex 2 from methylating Histone 3 lysine 27

Jensen, M.; Garcia Bonete, M.-J.; Anindya, A. L.; Andersson, K.; Erlandsson, M. C.; Oparina, N.; Brath, U.; Chandrasekaran, V.; Bokarewa, M.; Katona, G.

10.1101/2022.04.27.489567 — molecular biology — Posted on 2022-04-27

550 Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation domains in mammalian cells

Esteve, P.-O.; Sen, S.; Udayakumaran Nair Sunitha Kumary, V.; Ruse, C.; Chin, H. G.; Pradhan, S.

10.1101/2021.11.13.468478 — molecular biology — Posted on 2022-04-27

551 The connectional anatomy of visual mental imagery: evidence from a patient with left occipito-temporal damage

Hajhajate, D.; Kaufmann, B.; Liu, J.; Siuda-Krzywicka, K.; Bartolomeo, P.

10.1101/2022.02.15.480510 — neuroscience — Posted on 2022-04-27

552 Elongated Hypocotyl 5 (HY5) regulates BRUTUS (BTS) to maintain Iron homeostasis in Arabidopsis thaliana.

Mankotia, S.; Singh, D.; Monika, K.; Meena, H.; Meena, V.; Yadav, R.; Pandey, A. K.; Satbhai, S. B.

10.1101/2022.04.26.489524 — plant biology — Posted on 2022-04-27

553 Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice

Lewis, J. E.; Woodward, O. R.; Nuzzaci, D.; Smith, C. A.; Adriaenssens, A. E.; Billing, L.; Brighton, C.; Phillips, B. U.; Tadross, J. A.; Kinston, S. J.; Ciabatti, E.; Gottgens, B.; Tripodi, M.; Hornigold, D.; Baker, D.; Gribble, F. M.; Reimann, F.

10.1101/2021.06.26.450020 — physiology — Posted on 2022-04-27

554 Bacterial lipopolysaccharide modulates immune response in the colorectal tumor microenvironment

Sulit, A. K.; Daigneault, M.; Allen-Vercoe, E.; Silander, O. K.; Hock, B.; McKenzie, J.; Pearson, J.; Frizelle, F. A.; Schmeier, S.; Purcell, R.

10.1101/2022.04.26.489473 — cancer biology — Posted on 2022-04-27

555 Chromosome-level draft assemblies of the snow leopard, African leopard, and tiger (Panthera uncia, Panthera pardus pardus, and Panthera tigris)

Armstrong, E. E.; Campana, M. G.; Solari, K. A.; Morgan, S. R.; Ryder, O. A.; Naude, V. N.; Samelius, G.; Sharma, K.; Hadly, E. A.; Petrov, D. A.

10.1101/2022.04.26.489474 — genomics — Posted on 2022-04-27

556 Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting

Tirincsi, A.; O Keefe, S.; Nguyen, D.; Sicking, M.; Dudek, J.; Foerster, F.; Jung, M.; Hadzibeganovic, D.; Helms, V.; High, S.; Zimmermann, R.; Lang, S.

10.1101/2022.04.27.489649 — cell biology — Posted on 2022-04-27

557 Lola-I is a developmentally regulated promoter pioneer factor

Ramalingam, V.; Yu, X.; Slaughter, B. D.; Unruh, J. R.; Brennan, K. J.; Onyshchenko, A.; Lange, J. J.; Natarajan, M.; Buck, M.; Zeitlinger, J.

10.1101/2022.04.25.489272 — genomics — Posted on 2022-04-27

558 Secondary metabolites produced during Aspergillus fumigatus and Pseudomonas aeruginosa biofilm formation

Bastos, R.; Akiyama, D.; dos Reis, T. F.; Colabardini, A. C.; Luperini, R. S.; de Castro, P. A.; Baldini, R. L.; Pacheco Fill, T.; Goldman, G. H.

10.1101/2022.04.25.489484 — microbiology — Posted on 2022-04-27

559 Boid Inclusion Body Disease (BIBD) Is Also a Disease of Wild Boa Constrictors

Alfaro-Alarcon, A.; Hetzel, U.; Smura, T.; Baggio, F.; Morales, J. A.; Kipar, A.; Hepojoki, J.

10.1101/2022.04.25.489483 — microbiology — Posted on 2022-04-27

560 Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates

Tkachev, V.; Vanderbeck, A.; Perkey, E.; Furlan, S. N.; McGuckin, C.; Gomez Atria, D.; Gerdemann, U.; Rui, X.; Lane, J.; Hunt, D. J.; Zheng, H.; Colonna, L.; Hoffman, M.; Yu, A.; Kelly, S.; Allman, A.; Burbach, B.; Shimizu, Y.; Panoskaltsis-Mortari, A.; Chen, G.; Carpenter, S.; Harari, O.; Kuhnert, F.; Thurston, G.; Blazar, B. R.; Kean, L. S.; Maillard, I.

10.1101/2022.04.23.488844 — immunology — Posted on 2022-04-27

561 A hybrid boundary element-finite element method to solve the EEG forward problem

Dayarian, N.; Khadem, A.

10.1101/2021.12.27.474309 — neuroscience — Posted on 2022-04-27

562 Assessment of local potato cultivars found in Cis-Himalayan region of West Bengal through morphology and biochemical profiling

10.1101/2022.04.27.489635 — plant biology — Posted on 2022-04-27

563 Single-cell tracking data aimed for big data analyses

Korsnes, M. S.; Korsnes, R.

10.1101/2022.04.26.489486 — cell biology — Posted on 2022-04-27

564 Achieving improved accuracy for imputation of ancient DNA

Ausmees, K.; Nettelblad, C.

10.1101/2022.04.26.489533 — genomics — Posted on 2022-04-27

565 Fear engrams and NPYergic circuit in the dorsal dentate gyrus determine remote fear memory generalization.

Raza, S. A.; Klinger, K.; del Angel, M.; Emre Demiray, Y.; Caliskan, G.; R. Kreutz, M.; Stork, O.

10.1101/2022.04.26.489543 — neuroscience — Posted on 2022-04-27

566 Assessing pyrethroid resistance status in the Culex pipiens complex (Diptera: Culicidae) from the northwest suburbs of Chicago, Illinois using Cox regression of bottle bioassays and other detection tools

Burgess, E. R.; Lopez, K.; Irwin, P.; Jaeger, C. P.; Estep, A.

10.1101/2022.04.26.489519 — pharmacology and toxicology — Posted on 2022-04-26

567 Mycobacterium tuberculosis transcriptional regulator Rv1019 is upregulated in hypoxia and negatively regulates Rv3230c-Rv3229c operon encoding enzymes in the oleic acid biosynthetic pathway

Pushparajan, A. R.; Edison, L. K.; Ajay Kumar, R.

10.1101/2022.04.26.489556 — molecular biology — Posted on 2022-04-26

568 Pervasive transcription enhances the accessibility of H-NS-silenced promoters and generates bistability in Salmonella virulence gene expression

Figueroa, N.; Sanchez-Romero, M. A.; Kerboriou, P.; Naquin, D.; Mendes, C.; Bouloc, P.; Casadesus, J.; Bossi, L.

10.1101/2022.04.26.489344 — microbiology — Posted on 2022-04-26

569 A novel hidden Markov approach to studying dynamic functional connectivity states in human neuroimaging

Hussain, S.; Langley, J.; Seitz, A. R.; Hu, X.; Peters, M. A. K.

10.1101/2022.02.02.478844 — neuroscience — Posted on 2022-04-26

570 nucGEMs probe the biophysical properties of the nucleoplasm

Shu, T.; Szoradi, T.; Kidiyoor, G. R.; Xie, Y.; Herzog, N. L.; Bazley, A.; Bonucci, M.; Keegan, S.; Saxena, S.; Ettefa, F.; Brittingham, G. P.; Lemiere, J.; Fenyo, D.; Chang, F.; Delarue, M.; Holt, L. J.

10.1101/2021.11.18.469159 — biophysics — Posted on 2022-04-26

571 Trimethylamine N-oxide (TMAO) enhances substrate mechanical stability probed by single molecule magnetic tweezers

Chaudhuri, D.; Chowdhury, D.; Chakraborty, S.; Dutta, A.; Mistry, A.; Haldar, S.

10.1101/2022.04.26.489563 — biophysics — Posted on 2022-04-26

572 On the Prediction of non-CG DNA Methylation

Sereshki, S.; Omirou, M.; Fasoula, D.; Lonardi, S.

10.1101/2022.04.26.489600 — bioinformatics — Posted on 2022-04-26

573 Differing Associations between Optic Nerve Head Strains and Visual Field Loss in Normal- and High-Tension Glaucoma Subjects

Chuangsuwanich, T.; Tun, T. A.; Braeu, F. A.; Wang, X.; Chin, Z. Y.; Panda, S. K.; Buist, M.; Strouthidis, N.; Perera, S.; Nongpiur, M.; Aung, T.; Girard, M. J. A.

10.1101/2021.12.15.472712 — bioengineering — Posted on 2022-04-26

574 Adduction Induces Large Optic Nerve Head Deformations in Subjects with Normal Tension Glaucoma

Chuangsuwanich, T.; Tun, T. A.; Braeu, F. A.; Wang, X.; Chin, Z. Y.; Panda, S. K.; Buist, M.; Milea, D.; Strouthidis, N.; Perera, S.; Nongpiur, M. E.; Tin, A.; Girard, M. J. A.

10.1101/2021.08.25.457300 — bioengineering — Posted on 2022-04-26

575 Conditional covalent lethality driven by oncometabolite accumulation

Perez, M.; Nance, K. D.; Bak, D. W.; Gamage, S. T.; Najera, S. S.; Conte, A. N.; Linehan, W. M.; Weerapana, E.; Meier, J. L.

10.1101/2022.04.26.489575 — biochemistry — Posted on 2022-04-26

576 The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex

Roedl, S.; den Brave, F.; Raeschle, M.; Lenhard, S.; Groh, C.; Becker, H.; Zimmermann, J.; Morgan, B.; Richling, E.; Becker, T.; Herrmann, J. M.

10.1101/2022.04.26.489513 — biochemistry — Posted on 2022-04-26

577 Evaluation of CA repeat arrays as targets for MeCP2 function in the brain

Chhatbar, K.; Connelly, J.; Webb, S.; Kriaucionis, S.; Bird, A.

10.1101/2022.04.26.489598 — genomics — Posted on 2022-04-26

578 Investigating the impact of database choice on the accuracy of metagenomic read classification for the rumen microbiome

Smith, R. H.; Glendinning, L.; Walker, A. W.; Watson, M.

10.1101/2022.04.26.489553 — genomics — Posted on 2022-04-26

579 Active communities and growth of soil microorganisms are framed by mean annual precipitation in three California annual grasslands

Foley, M. M.; Blazewicz, S. J.; McFarlane, K. J.; Greenlon, A.; Hayer, M.; Kimbrel, J. A.; Koch, B. J.; Monsaint-Queeney, V.; Morrison, K.; Morrissey, E. M.; Hungate, B. A.; Pett-Ridge, J.

10.1101/2021.12.06.471491 — ecology — Posted on 2022-04-26

580 A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy.

Tomer, D.; Arriagada, C.; Munshi, S.; Alexander, B.; French, B.; Vedula, P.; Caorsi, V.; House, A.; Guvendiren, M.; Kashina, A.; Schwarzbauer, J.; Astrof, S.

10.1101/2020.09.09.290130 — cell biology — Posted on 2022-04-26

581 Upregulation of Somatostatin Receptor Type 2 in a Receptor-Deficient In Vivo Pancreatic Neuroendocrine Tumor Model Improves Tumor Response to Targeted 177Lu-DOTATATE

Sharma, R.; Earla, B.; Baidoo, K.; Zeiger, M. A.; Madigan, J. P.; Escorcia, F. E.; Sadowski, S. M.

10.1101/2022.04.25.489401 — molecular biology — Posted on 2022-04-26

582 Donor strand complementation, isopeptide bonds and glycosylation stabilise highly resilient archaeal thread filaments

Gaines, M.; Isupov, M. N.; Sivabalasarma, S.; Haque, R. U.; McLaren, M.; Tripp, P.; Neuhaus, A.; Gold, V.; Albers, S.-V.; Daum, B.

10.1101/2022.04.26.489512 — microbiology — Posted on 2022-04-26

583 Human Cytomegalovirus induces neuronal enolase to support virally-mediated metabolicremodeling

Moreno, I.; Rodriguez-Sanchez, I.; Schafer, X.; Munger, J.

10.1101/2022.04.26.488511 — microbiology — Posted on 2022-04-26

584 p75NTR prevents the onset of cerebellar granule cell migration via RhoA activation

Zanin, J. P.; Friedman, W. J.

10.1101/2022.04.26.489604 — neuroscience — Posted on 2022-04-26

585 Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and C53-mediated autophagy

Picchianti, L.; Sanchez de Medina Hernandez, V.; Zhan, N.; Irwin, N. A. T.; Stephani, M.; Hornegger, H.; Beveridge, R.; Sawa-Makarska, J.; Lendl, T.; Grujic, N.; Martens, S.; Richards, T. A.; Clausen, T.; Ramundo, S.; Karagoz, E. G.; Dagdas, Y.

10.1101/2022.04.26.489478 — plant biology — Posted on 2022-04-26

586 SWAP1-SFPS-RRC1 splicing factor complex modulates pre-mRNA splicing to promote photomorphogenesis in Arabidopsis

Kathare, P. K.; Xin, R.; Ganesan, A. S.; June, V. M.; Reddy, A. S.; Huq, E.

10.1101/2022.04.26.489584 — plant biology — Posted on 2022-04-26

587 Cancer stem cell-derived extracellular vesicles preferentially target MHCII- macrophages and PD1+ T cells in the tumor microenvironment

Gonzalez-Callejo, P.; Guo, Z.; Ziglari, T.; Claudio, N. M.; Oshimori, N.; Seras-Franzoso, J.; Pucci, F.

10.1101/2022.04.26.489579 — cancer biology — Posted on 2022-04-26

588 The EGFR-STYK1-FGF1 axis sustains functional drug tolerance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer

Eggermont, C.; Giron, P.; Noeparast, M.; Vandenplas, H.; Aza-Blanc, P.; Gutierrez, G. J.; De Greve, J.

10.1101/2022.04.26.489539 — cancer biology — Posted on 2022-04-26

589 An outstanding bacterial membranome requires CRISPR-Cas systems to avoid the intervention of phages

Rubio, A.; Sprang, M.; Garzon, A.; Pachon-Ibanez, M. E.; Pachon, J.; Andrade-Navarro, M. A.; Perez-Pulido, A. J.

10.1101/2022.04.26.489349 — bioinformatics — Posted on 2022-04-26

590 Detection of low numbers of bacterial cells in pharmaceutical drug product using Raman Spectroscopy and PLS-DA multivariate analysis.

Grosso, R. A.; Walther, A. R.; Brunbech, E.; Sorensen, A.; Schebye, B.; Olsen, K. E.; Qu, H.; Hedegaard, M. A.; Arnspang, E. C.

10.1101/2022.04.26.489535 — bioengineering — Posted on 2022-04-26

591 Relative abundance data can misrepresent heritability of the microbiome

Bruijning, M.; Ayroles, J. F.; Henry, L. P.; Koskella, B.; Meyer, K. M.; Metcalf, C. J. E.

10.1101/2022.04.26.489345 — evolutionary biology — Posted on 2022-04-26

592 The Drosophila Fab-7 boundary element modulates Abd-B gene activity in the genital disc by guiding an inversion of collinear chromatin organization and alternative promoter use

Moniot-Perron, L.; Moindrot, B.; Manceau, L.; Edouard, J.; Jaszczyszyn, Y.; Gilardi-Hebenstreit, P.; Hernandez, C.; Bloyer, S.; Noordermeer, D.

10.1101/2022.04.26.489596 — developmental biology — Posted on 2022-04-26

593 Allosteric links between the hydrophilic N-terminus and transmembrane core of human Na+/H+ antiporter NHA2

Velazquez, D.; Prusa, V.; Masrati, G.; Sychrova, H.; Ben-Tal, N.; Zimmermannova, O.

10.1101/2022.04.26.489501 — molecular biology — Posted on 2022-04-26

594 A de novo transcription-dependent TAD boundary underpins critical multiway interactions during antibody class switch recombination

Costea, J.; Schoeberl, U. E.; Malzl, D.; von der Linde, M.; Fitz, J.; Makharova, M.; Goloborodko, A.; Pavri, R.

10.1101/2022.04.26.489407 — molecular biology — Posted on 2022-04-26

595 Targeted genomic sequencing with probe capture for discovery and surveillance of coronaviruses in bats

Kuchinski, K. S.; Loos, K. D.; Suchan, D. M.; Russell, J. N.; Sies, A. N.; Kumakamba, C.; Muyembe, F.; Mbala Kingebeni, P.; Ngay Lukusa, I.; NKawa, F.; Atibu Losoma, J.; Makuwa, M.; Gillis, A.; LeBreton, M.; Ayukekbong, J. A.; Monagin, C.; Joly, D. O.; Saylors, K.; Wolfe, N. D.; Rubin, E. M.; Muyembe Tamfum, J. J.; Prystajecky, N. A.; McIver, D. J.; Lange, C. E.; Cameron, A. D. S.

10.1101/2022.04.25.489472 — microbiology — Posted on 2022-04-26

596 LaeA-dependent production of small molecules of Aspergillus niger that compete with specific antibodies that bind to human immune receptors

Escobar, N.; Keizer, E.; van Neer, J.; Arentshorst, M.; van Strijp, J.; Haas, P.-J.; Ram, A.; Punt, P.; Wosten, H.; de Cock, H.

10.1101/2022.04.26.489527 — microbiology — Posted on 2022-04-26

597 Interpreting and de-noising genetically engineered barcodes in a DNA virus

Blois, S.; Goetz, B. M.; Bull, J. J.; Sullivan, C. S.

10.1101/2022.04.26.489490 — microbiology — Posted on 2022-04-26

598 Whole genome sequencing of three mesorhizobia isolated from northern Canada to identify genomic adaptations promoting nodulation in cold climates

Duan, Y. F.; Grogan, P.; Walker, V. K.; diCenzo, G. C.

10.1101/2022.04.26.489235 — microbiology — Posted on 2022-04-26

599 Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX

Shirasaki, T.; Feng, H.; Duyvesteyn, H. M. E.; Fusco, W. G.; McKnight, K. L.; Xie, L.; Boyce, M.; Kumar, S.; Barouch-Bentov, R.; Gonzalez-Lopez, O.; McNamara, R.; Wang, L.; Hertel-Wulff, A.; Chen, X.; Einav, S.; Duncan, J. A.; Kapustina, M.; Fry, E. E.; Stuart, D. I.; Lemon, S. M.

10.1101/2022.04.26.489493 — microbiology — Posted on 2022-04-26

600 2,4-Diacetylphloroglucinol Against Candida albicans: Biofilm Formation, Aspartyl Protease Production and Ultrastructure Changes

Stepanov, A. A.; Vasilchenko, A. S.

10.1101/2022.04.26.489565 — microbiology — Posted on 2022-04-26

601 Anti-SARS-Cov-2 S-RBD IgG formed after BNT162b2 vaccination can bind C1q and activate complement

Abu-Humaidan, A. H. A.; Ahmad, F. M.; Awajan, D.; Jarrar, R.; Alaridah, N.

10.1101/2022.04.24.489298 — immunology — Posted on 2022-04-26

602 Pseudomonas aeruginosa Elicits Sustained IL-1β Upregulation in Alveolar Macrophages from Lung Transplant Recipients

Britton, N.; Rueda, A. V.; Whiteside, S. A.; Mathew, J.; Kelley, M.; Agbor-Enoh, S.; McDyer, J.; Christie, J. D.; Collman, R. G.; Cox, A.; Shah, P.; D'Alessio, F.

10.1101/2022.04.26.489590 — immunology — Posted on 2022-04-26

603 A 3-Dimensional bioprinted human gut-liver axis model for studying Alcoholic Liver Disease

Meher, K.; Rottela, M.; K, S.; Iyer, S.; Kadiyala, G.; Vangala, S.; Chandran, S.; Saxena, U.

10.1101/2022.04.26.489511 — pharmacology and toxicology — Posted on 2022-04-26

604 Log-order improved in trans hammerhead ribozyme turnover rates: reevaluating therapeutic space for small catalytic RNAs

Myers, J. M.; Sullivan, J. M.

10.1101/2022.04.26.489422 — pharmacology and toxicology — Posted on 2022-04-26

605 Structural basis of human LRRK2 membrane recruitment and activation

Zhu, H.; Tonelli, F.; Alessi, D. R.; Sun, J.

10.1101/2022.04.26.489605 — biophysics — Posted on 2022-04-26

606 A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

Zhang, X.; Luo, F.; Zhang, H.; Guo, H.; Zhou, J.; Li, T.; Chen, S.; Song, S.; Shen, M.; Wu, Y.; Gao, Y.; Han, X.; Wang, Y.; Hu, C.; Lu, Y.; Wang, W.; Wang, K.; Tang, N.; Jin, T.; Yang, C.; Cheng, G.; Yang, H.; Jin, A.; Ji, X.; Gong, R.; Chiu, S.; Huang, A.

10.1101/2022.04.26.489529 — immunology — Posted on 2022-04-26

607 Mutational impact of APOBEC3B and APOBEC3A in a human cell line

Harris, R. S.; Jarvis, M.; Carpenter, M. A.; Temiz, N. A.; Brown, M.; Richards, K.; Argyris, P.; Brown, W.; Yee, D.

10.1101/2022.04.26.489523 — cancer biology — Posted on 2022-04-26

608 Life-long Dietary Restrictions have Negligible or Damaging Effects on Late-life Cognitive Performance: A Key Role for Genetics in Outcomes

Ouellette, A. R.; Hadad, N.; Deighan, A.; Robinson, L.; O'Connell, K. M. S.; Freund, A.; Churchill, G. A.; Kaczorowski, C.

10.1101/2022.04.09.487742 — animal behavior and cognition — Posted on 2022-04-26

609 Identification of Antimalarial Compounds that Inhibit Apicomplexan AP2 Proteins in the Human Malaria Parasite Plasmodium falciparum

Russell, T. J.; De Silva, E. K.; Crowley, V.; Shaw-Saliba, K.; Dube, N.; Josling, G.; Pasaje, C. F. A.; Kouskoumvekaki, I.; Panagiotou, G.; Niles, J. C.; JACOBS-LORENA, M.; Okafor, C. D.; Gamo, F.-J.; Llinas, M.

10.1101/2022.04.05.487101 — molecular biology — Posted on 2022-04-26

610 Strong basal/tonic TCR signals are associated with negative regulation of naive CD4+ T cells

Zinzow-Kramer, W. M.; Eggert, J.; Scharer, C. D.; Au-Yeung, B. B.

10.1101/2022.04.20.488956 — immunology — Posted on 2022-04-26

611 Top-down modulation of the retinal code via histaminergic neurons of the hypothalamus

Warwick, R. A.; Riccitelli, S.; Heukamp, A. S.; Yaakov, H.; Ankri, L.; Mayzel, J.; Gilead, N.; Parness-Yossifon, R.; Rivlin-Etzion, M.

10.1101/2022.04.26.489509 — neuroscience — Posted on 2022-04-26

612 Shape driven confluent rigidity transition in curved biological tissues

Thomas, E. C.; Hopyan, S.

10.1101/2022.04.20.488966 — biophysics — Posted on 2022-04-26

613 Image recognition based on deep learning in Haemonchus contortus motility assays

Zofka, M.; Nguyen, L. T.; Masatova, E.; Matouskova, P.

10.1101/2021.12.01.470699 — bioinformatics — Posted on 2022-04-26

614 First direct observation of 'elongated' conformational states in α-synuclein upon liquid-liquid phase separation

Ubbiali, D.; Fratini, M.; Piersimoni, L.; Ihling, C. H.; Kipping, M.; Heilmann, I.; Iacobucci, C.; Sinz, A.

10.1101/2022.04.20.488894 — biochemistry — Posted on 2022-04-26

615 A brain-inspired object-based attention network for multi-object recognition and visual reasoning

Adeli, H.; Ahn, S.; Zelinsky, G.

10.1101/2022.04.02.486850 — animal behavior and cognition — Posted on 2022-04-26

616 Architectural experience: clarifying its central components and their relation to core affect with a set of first-person-view videos

Gregorians, L.; Velasco, P. F.; Zisch, F.; Spiers, H. J.

10.1101/2022.04.05.487021 — animal behavior and cognition — Posted on 2022-04-26

617 The shifting importance of abiotic and biotic factors across the life cycles of wild pollinators

Ogilvie, J. E.; CaraDonna, P. J.

10.1101/2022.04.25.489447 — ecology — Posted on 2022-04-26

618 A Coxiella burnetii effector interacts with the host PAF1 complex and suppresses the innate immune response

Lopes Fischer, N.; Boyer, M. A.; Bradley, W. P.; Spruce, L. A.; Fazelinia, H.; Shin, S.

10.1101/2022.04.20.488957 — microbiology — Posted on 2022-04-26

619 Synergistic protection against secondary pneumococcal infection by human monoclonal antibodies targeting distinct epitopes

Gingerich, A. D.; Royer, F.; McCormick, A. L.; Scasny, A.; Vidal, J. E.; Mousa, J.

10.1101/2022.04.20.488872 — immunology — Posted on 2022-04-26

620 Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

Hagan, T.; Gerristen, B.; Tomalin, L. E.; Fourati, S.; Mule, M. P.; Chawla, D. G.; Rychkov, D.; Henrich, E.; Miller, H. E.; Diray-Arce, J.; Dunn, P.; Lee, A.; The Human Immunology Project Consortium (HIPC), ; Levy, O.; Gottardo, R.; Sarwal, M. M.; Tsang, J.; Suarez-Farinas, M.; Sekaly, R.-P.; Kleinstein, S.; Pulendran, B.

10.1101/2022.04.20.488939 — immunology — Posted on 2022-04-26

621 Riemannian geometry of functional connectivity matrices for multi-site attention-deficit/hyperactivity disorder data harmonization

Simeon, G.; Piella, G.; Camara, O.; Pareto, D.

10.1101/2021.09.01.458579 — neuroscience — Posted on 2022-04-26

622 The Statistical Trends of Protein Evolution: A Lesson from AlphaFold Database

Tang, Q.-Y.; Ren, W.; Wang, J.; Kaneko, K.

10.1101/2022.04.07.487447 — biophysics — Posted on 2022-04-26

623 Building a novel nuclear-organelle genomic framework for the fever tree (Cinchona pubescens Vahl) through short and long-read DNA data assemblies

Canales, N. A.; Perez Escobar, O. A.; Powell, R.; Topel, M.; Kidner, C.; Nesbitt, M.; Maldonado, C.; Barnes, C.; Ronsted, N.; Leitch, I.; Antonelli, A.

10.1101/2022.04.25.489452 — bioinformatics — Posted on 2022-04-26

624 Biophysical, Molecular and Proteomic profiling of Human Retinal Organoids derived Exosomes

Arthur, P.; Kandoi, S.; Sun, L.; Kalvala, A.; Kutlehria, S.; Bhattacharya, S.; Kulkarni, T.; Nimma, R.; Li, Y.; Lamba, D. A.; Singh, M.

10.1101/2022.04.25.489461 — bioengineering — Posted on 2022-04-26

625 Mesostats - A multiplexed, low-cost, do-it-yourself continuous culturing system for experimental evolution of mesocosms

Hansson, E. M.; Childs, D. Z.; Beckerman, A. P.

10.1101/2022.04.20.488910 — evolutionary biology — Posted on 2022-04-26

626 Endocycles support tissue growth and regeneration of the adult Drosophila accessory gland

Box, A. M.; Church, S. J.; Nandakumar, S.; Prasad, D.; Afrakhteh, A.; Taichman, R. S.; Buttitta, L.

10.1101/719013 — developmental biology — Posted on 2022-04-26

627 Persistence of parental age effect on somatic mutation rates across generations in Arabidopsis.

Ramamurthy, B.; Bhushan, S.; Singh, A. K.; Thakur, Y.

10.1101/2022.01.12.476102 — developmental biology — Posted on 2022-04-26

628 Single-cell tracking data aimed for big data analyses

Korsnes, M. S.; Korsnes, R.

10.1101/2022.04.26.489486 — cell biology — Posted on 2022-04-26

629 Calcium determines Lactiplantibacillus plantarum intraspecies competitive fitness

Marco, M. L.; Yu, A. O.; Wei, L.

10.1101/2022.04.25.489480 — microbiology — Posted on 2022-04-26

630 Community review: a robust and scalable selection system for resource allocation within open science and innovation communities

Graham, C. L. B.; Landrain, T. E.; Vjestica, A.; Greshake Tzovoras, B.; Masselot, C.; Lawton, E.; Haenel, L.; Blondel, L.; Santolini, M.

10.1101/2022.04.25.489391 — scientific communication and education — Posted on 2022-04-26

631 If Research is Not the Evidence, What is it? Explanations of the Lack of Research Citations in their Health Vlogs

Atef, N.

10.1101/2022.04.25.489430 — scientific communication and education — Posted on 2022-04-26

632 Real-time feeding behavior monitoring by electrical penetration graph rapidly reveals host plant susceptibility to crapemyrtle bark scale (Hemiptera: Eriococcidae)

Wu, B.; Chun, E.; Xie, R.; Knox, G. W.; Gu, M.; Qin, H.

10.1101/2022.04.25.489421 — plant biology — Posted on 2022-04-26

633 FebRNA: an automated fragment-ensemble-based model for building RNA 3D structures

Zhou, L.; Wang, X.; Yu, S.; Tan, Y.-L.; Tan, Z.-J.

10.1101/2022.04.25.489348 — biophysics — Posted on 2022-04-26

634 SeATAC: a tool for exploring the chromatin landscape and the role of pioneer factors

Dsouza, N.; Gong, W.; Garry, D.

10.1101/2022.04.25.489439 — bioinformatics — Posted on 2022-04-26

635 The regulation of circadian rhythm by insulin signaling in Drosophila

Yamaguchi, S. T.; Tomita, J.; Kume, K.

10.1101/2022.04.25.489482 — animal behavior and cognition — Posted on 2022-04-26

636 satmut_utils: a simulation and variant calling package for multiplexed assays of variant effect

Hoskins, I.; Sun, S.; Cote, A.; Roth, F. P.; Cenik, C.

10.1101/2022.04.25.489390 — genomics — Posted on 2022-04-26

637 Regulation of human trophoblast gene expression by endogenous retroviruses

Frost, J. M.; Amante, S. M.; Okae, H.; Jones, E. M.; Ashley, B.; Lewis, R. M.; Cleal, J. K.; Caley, M. P.; Arima, T.; Branco, M. R.

10.1101/2022.04.26.489485 — genetics — Posted on 2022-04-26

638 Genetic and peripheral visual system changes underlie evolving butterfly mate preference

VanKuren, N. W.; Buerkle, N. P.; Westerman, E. L.; Im, A. K.; Massardo, D. L.; Lu, W.; Palmer, S. E.; Kronforst, M. R.

10.1101/2022.04.25.489404 — evolutionary biology — Posted on 2022-04-26

639 Mobile Laser Scanner understory characterization: an exploratory study on hazel grouse in Italian Alps

Galluzzi, M.; Puletti, N.; Armanini, M.; Chirichella, R.; Mustoni, A.

10.1101/2022.04.26.489487 — ecology — Posted on 2022-04-26

640 ILC3s select for RORγt+ Tregs and establish tolerance to intestinal microbiota

Lyu, M.; Suzuki, H.; Kang, L.; Gaspal, F. F.; Zhou, W.; Goc, J.; Zhou, L.; Zhou, J. Z.; Zhang, W.; Live Cell Bank, J.; Shen, Z.; Fox, J. G.; Sockolow, R.; Laufer, T. M.; Fan, Y.; Eberl, G.; Withers, D. R.; Sonnenberg, G. F.

10.1101/2022.04.25.489463 — immunology — Posted on 2022-04-26

641 Sex-limited diversification of the eye in Heliconius butterflies

Buerkle, N. P.; VanKuren, N. W.; Westerman, E. L.; Kronforst, M. R.; Palmer, S. E.

10.1101/2022.04.25.489414 — neuroscience — Posted on 2022-04-26

642 High precision magnetoencephalography reveals increased right-inferior frontal gyrus beta power during response conflict

Daniel, P. L.; Bonaiuto, J. J.; Bestmann, S.; Aron, A. R.; Little, S.

10.1101/2022.04.25.489434 — neuroscience — Posted on 2022-04-26

643 Spatially-enhanced clusterwise inference for testing and localizing intermodal correspondence

Weinstein, S. M.; Vandekar, S. N.; Baller, E. B.; Tu, D.; Adebimpe, A.; Tapera, T. M.; Gur, R. C.; Gur, R. E.; Detre, J. A.; Raznahan, A.; Alexander-Bloch, A. F.; Satterthwaite, T. D.; Shinohara, R.; Park, J. Y.

10.1101/2022.04.25.489462 — neuroscience — Posted on 2022-04-26

644 Hydroquinone, a cigarette smoke compound, affects cartilage homeostasis through activation of the aryl hydrocarbon receptor pathway.

Heluany, C. S.; de Palma, A.; Day, N. J.; Farsky, S. H. P.; Nalesso, G.

10.1101/2022.04.25.489372 — pharmacology and toxicology — Posted on 2022-04-26

645 Salivary Proinflammatory Cytokines IL-1β, IL-6 And TNF Decrease With Age.

Costantino, E.; Castell, S. D.; Harman, M. F.; Pistoresi-Palencia, M. C.; Actis, A. B.

10.1101/2022.04.25.489450 — pathology — Posted on 2022-04-26

646 Mechanical confinement and DDR1 signalling synergise to regulate collagen-induced apoptosis in rhabdomyosarcoma cells

Gonzalez-Molina, J.; Kirchhof, K. M.; Rathod, B.; Moyano-Galceran, L.; Calvo-Noriega, M.; Kokaraki, G.; Bjorkoy, A.; Ehnman, M.; Carlson, J. W.; Lehti, K.

10.1101/2022.04.26.489526 — cancer biology — Posted on 2022-04-26

647 Mechanochemical signal transduction in synthetic cells

Jahnke, K.; Illig, M.; Scheffold, M.; Tran, M. P.; Mersdorf, U.; Göpfrich, K.

10.1101/2022.04.26.489423 — biophysics — Posted on 2022-04-26

648 IDENTIFICATION OF DYNAMIC MICROBIAL SIGNATURES IN LONGITUDINAL STUDIES

Calle, M. L.; Susin, A.

10.1101/2022.04.25.489415 — bioinformatics — Posted on 2022-04-26

649 Predicting coordinates of peptide features in raw timsTOF data with machine learning for targeted extraction reduces missing values in label-free DDA LC-MS/MS proteomics experiments

Wilding-McBride, D.; Infusini, G.; Webb, A. I.

10.1101/2022.04.25.489464 — bioinformatics — Posted on 2022-04-26

650 Computational modeling of posteroanterior lumbar traction by an automated massage bed: predicting intervertebral disc stresses and deformation

Cardoso, L.; Khadka, N.; Dmochowski, J. P.; Meneses, E.; Jin, Y.; Bikson, M.

10.1101/2022.04.25.489383 — bioengineering — Posted on 2022-04-26

651 Legacy of past exposure to hypoxia and warming regulates ecosystem service provided by oysters

Donelan, S. C.; Ogburn, M.; Breitburg, D.

10.1101/2022.04.25.488919 — ecology — Posted on 2022-04-26

652 Cardiomyocyte differentiation from iPS cells is delayed following knockout of Bcl-2

Vervliet, T.; Duelen, R.; La Rovere, R.; Roderick, l. H.; Sampaolesi, M.

10.1101/2022.01.05.475068 — developmental biology — Posted on 2022-04-26

653 Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues

Martinez-Ara, G.; Taberner, N.; Takayama, M.; Sandaltzopoulou, E.; Villava, C. E.; Takata, N.; Eiraku, M.; Ebisuya, M.

10.1101/2021.04.20.440475 — developmental biology — Posted on 2022-04-26

654 Integrative analysis of the 3D genome and epigenome in mouse embryonic tissues

Yu, M.; Zemke, N. R.; Chen, Z.; Juric, I.; Hu, R.; Raviram, R.; Abnousi, A.; Fang, R.; Zhang, Y.; Gorkin, D. U.; Li, Y.; Zhao, Y.; Lee, H. R.; Schmitt, A. D.; Qiu, Y.; Dickel, D. E.; Visel, A.; Pennacchio, L.; Hu, M.; Ren, B.

10.1101/2022.04.25.489471 — developmental biology — Posted on 2022-04-26

655 Early dosage compensation of zygotically-expressed genes in Drosophila melanogaster is mediated through a post-transcriptional regulatory mechanism

Blake, V. M.; Eisen, M.

10.1101/2022.04.25.489409 — molecular biology — Posted on 2022-04-26

656 Control of Ca2+ signals by astrocyte nanoscale morphology at tripartite synapses

Denizot, A.; Arizono, M.; Nägerl, V.; Berry, H.; De Schutter, E.

10.1101/2021.02.24.432635 — neuroscience — Posted on 2022-04-26

657 In vitro longitudinal lumbar spinal cord preparations to study sensory and recurrent motor microcircuits of juvenile mice

Ozyurt, G.; Ojeda-Alonso, J.; Beato, M.; Nascimento, F.

10.1101/2022.04.25.489385 — neuroscience — Posted on 2022-04-26

658 Decoding reward-curiosity conflict in decision-making from irrational behaviors

Konaka, Y.; Naoki, H.

10.1101/2022.04.24.489304 — neuroscience — Posted on 2022-04-26

659 Generation and analysis of context-specific genome-scale metabolic models derived from single-cell RNA-Seq data

Gustafsson, J.; Robinson, J. L.; Roshanzamir, F.; Jornsten, R.; Kerkhoven, E. J.; Nielsen, J.

10.1101/2022.04.25.489379 — systems biology — Posted on 2022-04-26

660 Optimizing Oscillators for Specific Tasks Predicts Preferred Biochemical Implementations

Agrahar, C.; Rust, M.

10.1101/2022.04.25.489380 — systems biology — Posted on 2022-04-26

661 Lower limb in sprinters with larger relative mass but not larger normalized moment of inertia: novel insights into human plasticity

Sado, N.; Ichinose, H.; Kawakami, Y.

10.1101/2022.02.25.482057 — physiology — Posted on 2022-04-26

662 Binding of the peptide deformylase on the ribosome surface modulates the structure and dynamics of the exit tunnel interior

McGrath, H.; Cernekova, M.; Kolar, M. H.

10.1101/2022.04.20.488877 — biophysics — Posted on 2022-04-26

663 On the generality and cognitive basis of base-rate neglect

Stengard, E.; Juslin, P.; Hahn, U.; van den Berg, R.

10.1101/2021.03.11.434913 — animal behavior and cognition — Posted on 2022-04-26

664 Scientific opportunities for developing essential biodiversity variables from satellite remote sensing in the context of the post-2020 global biodiversity framework

Timmermans, J.; Kissling, D.

10.1101/2022.04.25.489356 — ecology — Posted on 2022-04-26

665 Locomotion-induced gain of visual responses cannot explain visuomotor mismatch responses in layer 2/3 of primary visual cortex

Vasilevskaya, A.; Widmer, F. C.; Keller, G. B.; Jordan, R.

10.1101/2022.02.11.479795 — neuroscience — Posted on 2022-04-26

666 Transfer of weight information depends differently on used hand and handedness for perception and action

van Polanen, V.

10.1101/2022.04.25.489365 — neuroscience — Posted on 2022-04-26

667 All-optical recreation of naturalistic neural activity with a multifunctional transgenic reporter mouse

Bounds, H. A.; Sadahiro, M.; Hendricks, W. D.; Gajowa, M.; Gopakumar, K.; Quintana, D.; Tasic, B.; Daigle, T.; Zeng, H.; Oldenburg, I. A.; Adesnik, H.

10.1101/2021.10.05.463223 — neuroscience — Posted on 2022-04-26

668 Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's Disease

Shah, D.; Gsell, W.; Wahis, J.; Luckett, E.; Jamoulle, T.; Vermaercke, B.; Preman, P.; Moechars, D.; Hendrickx, V.; Jaspers, T.; Craessaerts, K.; Horre, K.; Wolfs, L.; Fiers, M.; Holt, M.; Thal, D.; Callaerts-Vegh, Z.; D'Hooge, R.; Vandenberghe, R.; Himmelreich, U.; Bonin, V.; De Strooper, B.

10.1101/2022.04.26.489446 — neuroscience — Posted on 2022-04-26

669 The limited place in cognitive space

Hodgetts, C. J.; Hahn, U.

10.1101/2022.04.25.489165 — neuroscience — Posted on 2022-04-26

670 Action sequence dynamics rely on accessory hyperdirect pathway-related targets in the striatum

Ferguson, L. A.; Matamales, M.; Balleine, B. W.; Bertran-Gonzalez, J.

10.1101/2022.03.28.486040 — neuroscience — Posted on 2022-04-26

671 Localization of chemical synapses and modulatory release sites in the cardiac ganglion of the crab, Cancer borealis

Rue, M. C. P.; Baas-Thomas, N.; Iyengar, P. S.; Scaria, L. K.; Marder, E.

10.1101/2022.04.25.489413 — neuroscience — Posted on 2022-04-26

672 Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Ozelci, E.; Mailand, E.; Ruegg, M.; Sakar, M. S.; Oates, A. C.

10.1101/2022.04.25.489395 — biophysics — Posted on 2022-04-26

673 Spatial Transcriptomics Prediction from Histology jointly through Transformer and Graph Neural Networks

yuansong, z.; Zhuoyi, W.; Weijiang, Y.; Rui, Y.; Bingling, L.; Zhonghui, T.; Yutong, L.; Yuedong, Y.

10.1101/2022.04.25.489397 — bioinformatics — Posted on 2022-04-26

674 GAGAM: a genomic annotation-based enrichment of scATAC-seq data for Gene Activity Matrix

Martini, L.; Bardini, R.; Savino, A.; Di Carlo, S.

10.1101/2022.01.24.477458 — bioinformatics — Posted on 2022-04-26

675 Mixture Margin Random-effects Copula Models for Inferring Temporally Conserved Microbial Co-variation Networks from Longitudinal Data

Deek, R. A.; Li, H.

10.1101/2022.04.25.489333 — bioinformatics — Posted on 2022-04-26

676 High-resolution line-scan Brillouin microscopy for live-imaging of mechanical properties during embryo development

Bevilacqua, C.; Gomez, J. M.; Fiuza, U.-M.; Chan, C. J.; Wang, L.; Hambura, S.; Eguren, M.; Ellenberg, J.; Diz-Munoz, A.; Leptin, M.; Prevedel, R.

10.1101/2022.04.25.489364 — bioengineering — Posted on 2022-04-26

677 Life-long Dietary Restrictions have Negligible or Damaging Effects on Late-life Cognitive Performance: A Key Role for Genetics in Outcomes

Ouellette, A. R.; Hadad, N.; Deighan, A.; Robinson, L.; O'Connell, K. M. S.; Freund, A.; Churchill, G. A.; Kaczorowski, C.

10.1101/2022.04.09.487742 — animal behavior and cognition — Posted on 2022-04-26

678 Mating strategy predicts gene presence/absence patterns in a genus of simultaneously hermaphroditic flatworms

Wiberg, R. A. W.; Viktorin, G.; Scharer, L.

10.1101/2022.04.25.489193 — evolutionary biology — Posted on 2022-04-26

679 A generic risk assessment model for animal disease incursion through wildlife

Counotte, M. J.; Petie, R.; van Klink, E.; de Vos, C. J.

10.1101/2022.04.25.489353 — ecology — Posted on 2022-04-26

680 CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

Schatton, D.; Di Pietro, G.; Szczepanowska, K.; Veronese, M.; Marx, M.-C.; Braunohler, K.; Barth, E.; Muller, S.; Giavalisco, P.; Langer, T.; Trifunovic, A.; Rugarli, E. I.

10.1101/2021.10.20.465082 — cell biology — Posted on 2022-04-26

681 Histone H2A serine-1 phosphorylation is a chaperone-dependent signal for dimerization with H2B and for enhanced deposition

Onikubo, T.; Wang, W.-l.; Shechter, D. M.

10.1101/2022.04.20.488954 — molecular biology — Posted on 2022-04-26

682 Transcranial Direct Current Stimulation Alters the Waveform Shape of Cortical Gamma Oscillations

Marshall, T. R.; Quinn, A. J.; Jensen, O.; Bergmann, T. O.

10.1101/2022.04.25.489371 — neuroscience — Posted on 2022-04-26

683 Eyeblink conditioning performance and brain-wide C-fos expression in male and female mice

Roa Oyaga, M.; Serra, I.; Kurup, D.; Koekkoek, S. K. E.; Badura, A.

10.1101/2021.10.15.464518 — neuroscience — Posted on 2022-04-26

684 From retina to motoneurons: a substrate for visuomotor transformation in salamanders

Flaive, A.; Ryczko, D.

10.1101/2022.04.25.489378 — neuroscience — Posted on 2022-04-26

685 Brain-to-brain concordance in child-parent dyads underlies children's psychological wellbeing

Su, H.; Young, C. B.; Han, Z. R.; Xu, J.; Xiong, B.; Wang, J.; Hao, L.; Yang, Z.; Chen, G.; Qin, S.

10.1101/2022.03.30.486310 — neuroscience — Posted on 2022-04-26

686 A comparison of ImageJ and machine learning based image analysis methods to measure cassava bacterial blight disease severity

Elliott, K.; Berry, J. C.; Hobin, K.; Bart, R. S.

10.1101/2022.04.25.488914 — plant biology — Posted on 2022-04-26

687 Ancestral Body Plan and Adaptive Radiation of Sauropterygian Marine Reptiles

Wang, W.; Shang, Q.; Cheng, L.; Wu, X.-C.; Li, C.

10.1101/2022.04.25.489368 — paleontology — Posted on 2022-04-26

688 In silico modelling demonstrates that user variability during tumour measurement can affect in vivo therapeutic efficacy outcomes

Murkin, J. T.; Amos, H. E.; Brough, D. W.; Turley, K. D.

10.1101/2022.04.20.487864 — bioinformatics — Posted on 2022-04-26

689 Depicting pseudotime-lagged causality across single-cell trajectories for accurate gene-regulatory inference

Reagor, C. C.; Velez-Angel, N.; Hudspeth, A. J.

10.1101/2022.04.25.489377 — bioinformatics — Posted on 2022-04-26

690 Reverse engineering environmental metatranscriptomes clarifies best practices for eukaryotic assembly

Krinos, A. I.; Cohen, N. R.; Follows, M. J.; Alexander, H.

10.1101/2022.04.25.489326 — bioinformatics — Posted on 2022-04-26

691 Rapid biomechanical imaging at low irradiation level via dual line-scanning Brillouin microscopy

Zhang, J.; Nikolic, M.; Tanner, K.; Scarcelli, G.

10.1101/2022.04.25.489096 — bioengineering — Posted on 2022-04-26

692 Long-term imaging reveals behavioral plasticity during C. elegans dauer exit

Preusser, F.; Neuschulz, A.; Junker, J. P.; Rajewsky, N.; Preibisch, S.

10.1101/2022.04.25.489360 — animal behavior and cognition — Posted on 2022-04-26

693 In silico analysis of imprinted gene expression in the mouse skin.

Marr, A. K.; Boughorbel, S.; Toufiq, M.; El Anbari, M.; Chouchane, A. I.; Kino, T.

10.1101/2020.06.04.134031 — genetics — Posted on 2022-04-26

694 Next-generation matrices for marine metapopulations: the case of sea lice on salmon farms

Harrington, P. D.; Cantrell, D. L.; Lewis, M. A.

10.1101/2022.04.25.489382 — ecology — Posted on 2022-04-26

695 The BLMP-1 transcription factor promotes oscillatory gene expression to achieve timely molting

Hauser, Y. P.; Meeuse, M. W.; Gaidatzis, D.; Grosshans, H.

10.1101/2021.07.05.450828 — developmental biology — Posted on 2022-04-26

696 Huntington's Disease Produces Multiplexed Transcriptional Vulnerabilities of StriatalD1-D2 and Striosome-Matrix Neurons

Matsushima, A.; Pineda, S. S.; Crittenden, J. R.; Lee, H.; Galani, K.; Mantero, J. C.; Kellis, M.; Heiman, M.; Graybiel, A. M.

10.1101/2022.04.25.489455 — neuroscience — Posted on 2022-04-26

697 Preterm infants voice processing is mediated by voice familiarity

Filippa, M.; Benis, D.; Adam-Darque, A.; Huppi, P. S.; Grandjean, D.

10.1101/2022.04.26.489394 — neuroscience — Posted on 2022-04-26

698 Predicting individual skill learning, a cautionary tale

Abeles, D.; Herszage, J.; Shahar, M.; Censor, N.

10.1101/2022.04.24.489296 — neuroscience — Posted on 2022-04-26

699 Tailoring CRISPR-Cas Immunity for the Degradation of Antibiotic Resistance Genes

Li, X.; Bao, N.; Yan, Z.; Yuan, X.-Z.; Wang, S.-G.; Xia, P.-F.

10.1101/2022.03.09.483686 — synthetic biology — Posted on 2022-04-26

700 Changes in prefrontal GABA and glutamate through adolescence supports excitation/inhibition balance

Perica, M. I.; Calabro, F.; Larsen, B.; Foran, W.; Yushmanov, V. E.; Hetherington, H.; Tervo-Clemmens, B.; Moon, C.-H.; Luna, B.

10.1101/2022.04.25.489387 — neuroscience — Posted on 2022-04-26

701 The genomic basis and environmental correlates of local adaptation in the Atlantic horse mackerel (Trachurus trachurus)

Fuentes-Pardo, A. P.; Farrell, E. D.; Pettersson, M. E.; Sprehn, C. G.; Andersson, L.

10.1101/2022.04.25.489172 — genomics — Posted on 2022-04-25

702 Super-enhancer signature reveals key mechanisms associated with resistance to non-alcoholicsteatohepatitis in humans with obesity

Hung, Y.-H.; Sritharan, R.; Vohl, M.-C.; Ilkayeva, O.; Biertho, L.; Tchernof, A.; White, P.; Sethupathy, P.

10.1101/2021.08.20.457162 — genomics — Posted on 2022-04-25

703 CircEML1 facilitates the steroid synthesis in follicular granulosa cells of chicken through sponging gga-miR-449a to release IGF2BP3 expression

Li, J.; Si, S.-J.; Wu, X.; Zhang, Z.; Li, C.; Tao, Y.; Yang, P.-K.; Li, D.; Li, G.-X.; Liu, X.-J.; Tian, Y.; Kang, X.-T.

10.1101/2022.04.25.489339 — molecular biology — Posted on 2022-04-25

704 GlycoVHH: Introducing N-glycans on the camelid VHH antibody scaffold - Optimal sites and use for macrophage delivery

van Schie, L.; Van Breedam, W.; Roels, C.; Schepens, B.; Frank, M.; Mehdipour, A. R.; Laukens, B.; Nerinckx, W.; Santens, F.; Devos, S.; Rossey, I.; Thooft, K.; Vanmarcke, S.; Van Hecke, A.; Callewaert, N.

10.1101/2022.04.25.489312 — molecular biology — Posted on 2022-04-25

705 Drug design and repurposing with a sequence-to-drug paradigm

Chen, L.; Fan, Z.; Chang, J.; Yang, R.; Guo, H.; Zhang, Y.; Yang, T.; Zhou, C.; Chen, Z.; Zheng, C.; Hao, X.; Zhang, K.; Cui, R.; Ding, Y.; Zhang, N.; Luo, X.; Jiang, H.; Zhang, S.; Zheng, M.

10.1101/2022.03.26.485909 — molecular biology — Posted on 2022-04-25

706 Behavioral and molecular underpinnings of performance variability in eyeblink conditioning in male and female mice

Roa Oyaga, M.; Serra, I.; Kurup, D.; Koekkoek, S. K. E.; Badura, A.

10.1101/2021.10.15.464518 — neuroscience — Posted on 2022-04-25

707 Great-tailed Grackles (Quiscalus mexicanus) as a tolerant host of avian malaria parasites

Pacheco, M. A.; Ferreira, F. C.; Logan, C. J.; McCune, K. B.; MacPherson, M. P.; Albino Miranda, S.; Santiago-Alarcon, D.; Escalante, A. A.

10.1101/2022.04.25.489425 — zoology — Posted on 2022-04-25

708 Geographic Name Resolution Service: A tool for the standardization and indexing of world political division names, with applications to species distribution modeling

Boyle, B. L.; Maitner, B. S.; Barbosa, G. G. C.; Sajja, R. K.; Feng, X.; Merow, C.; Newman, E. A.; Park, D. S.; Roehrdanz, P. R.; Enquist, B. J.

10.1101/2022.04.25.489424 — bioinformatics — Posted on 2022-04-25

709 Effects of axon branching and asymmetry between the branches on transport, mean age, and age density distributions of mitochondria in neurons

Kuznetsov, I. A.; Kuznetsov, A. V.

10.1101/2022.04.25.489429 — bioengineering — Posted on 2022-04-25

710 Spatial patterns of evolutionary diversity in Cactaceae show low ecological representation within protected areas

Amaral, D. T.; Bonatelli, I. A. S.; Romeiro-Brito, M.; Moraes, E. M.; Franco, F. F.

10.1101/2022.04.25.489403 — genetics — Posted on 2022-04-25

711 The nucleus bypasses obstacles by deforming like a drop with surface tension mediated by lamin A/C

Katiyar, A.; Zhang, J.; Antani, J. D.; Yu, Y.; Scott, K. L.; Lele, P. P.; Reinhart-King, C. A.; Sniadecki, N. J.; Roux, K. J.; Dickinson, R. B.; Lele, T. P.

10.1101/2022.03.10.483838 — cell biology — Posted on 2022-04-25

712 Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies

Robinson, C.-A.; Singh, G. K.; Kleer, M.; Castle, E. L.; Boudreau, B. Q.; Corcoran, J. A.

10.1101/2021.02.07.430164 — cell biology — Posted on 2022-04-25

713 Using genomes and evolutionary analyses to screen for host-specificity and arms-race dynamics in the plant pathogen Xylella fastidiosa

Batarseh, T. N.; Morales Cruz, A.; Ingel, B.; Roper, M. C.; Gaut, B. S.

10.1101/2022.04.25.489460 — microbiology — Posted on 2022-04-25

714 Distinct complexes containing the cytosolic type III secretion system ATPase resolved by 3D single-molecule tracking in live Yersinia enterocolitica

Prindle, J. R.; Rocha, J.; Wang, Y.; Diepold, A.; Gahlmann, A.

10.1101/2022.04.25.488798 — microbiology — Posted on 2022-04-25

715 CLASP2 stabilizes GDP-associated terminal tubulins to prevent microtubule catastrophe

Luo, W.; Demidov, V.; Shen, Q.; Hugo, G.; Chakraborty, M.; Maiorov, A.; Ataullakhanov, F.; Lin, C.; Maiato, H.; Grishchuk, E.

10.1101/2022.04.25.489454 — biophysics — Posted on 2022-04-25

716 Method for quantifying the metabolic boundary fluxes of cell cultures in large cohorts by high resolution hydrophilic liquid chromatography mass spectrometry

Groves, R. A.; Mapar, M.; Aburashed, R.; Ponce, L. F.; Bishop, S. L.; Rydzak, T.; Drikic, M.; Bihan, D. G.; Benediktsson, H.; Clement, F.; Gregson, D. B.; Lewis, I. A.

10.1101/2022.04.25.489416 — biochemistry — Posted on 2022-04-25

717 Inferring cell-type-specific causal gene regulatory networks during human neurogenesis

Aygün, N.; Liang, D.; Crouse, W. L.; Keele, G. R.; Love, M. I.; Stein, J. L.

10.1101/2022.04.25.488920 — genomics — Posted on 2022-04-25

718 Linkage mapping reveals loci that underlie differences in C. elegans growth

Nyaanga, J.; Andersen, E. C.

10.1101/2022.04.25.489412 — genomics — Posted on 2022-04-25

719 Epigenetic Control of Hundreds of Chromosome-Associated lncRNA Genes Essential for Replication and Stability

Heskett, M. B.; Vouzas, A. E.; Smith, L. G.; Yates, P. A.; Boniface, C.; Bouhassira, E. E.; Spellman, P. T.; Gilbert, D. M.; Thayer, M. J.

10.1101/2022.04.25.489405 — genetics — Posted on 2022-04-25

720 Initiator tRNA lacking 1-methyladenosine is unexpectedly targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species

Tasak, M.; Phizicky, E. M.

10.1101/2022.04.25.489336 — genetics — Posted on 2022-04-25

721 Sequences and proteins that influence mRNA processing in Trypanosoma brucei: evolutionary conservation of SR-domain and PTB protein functions.

Waithaka, A.; Maiakovska, O.; Grimm, D.; Melo do Nascimento, L.; Clayton, C.

10.1101/2022.04.25.489340 — molecular biology — Posted on 2022-04-25

722 Experimental infection of Artibeus lituratus bats and no detection of Zika virus in neotropical bats from French Guyana, Peru, and Costa Rica, suggest a limited role of bats in Zika transmission.

Aguilar-Setien, A.; Salas-Rojas, M.; Galvez-Romero, G.; Almazan-Marin, C.; Moreira-Soto, A.; Alfonso-Toledo, J.; Obregon-Morales, C.; Garcia-Flores, M.; Garcia-Baltazar, A.; Serra-Cobo, J.; Lopez-Roig, M.; Reyes-Puma, N.; Peniche-Ovares, M.; Romero-Vega, M.; Barrantes-Murillo, D. F.; Soto-Garita, C.; Alfaro-Alarcon, A.; Corrales-Aguilar, E.; Lopez-Diaz, O.; Drexler, F.

10.1101/2022.04.25.489338 — microbiology — Posted on 2022-04-25

723 MECP2 expression coincides with age-dependent tactile sensory deficits in a female mouse model for Rett syndrome

Mykins, M.; Layo-Carris, D. E.; Dunn, L.; Perez, S.; Mcbryar, A.; Lau, B. Y. B.; Krishnan, K.

10.1101/2022.04.25.482695 — neuroscience — Posted on 2022-04-25

724 Linking individual differences in human primary visual cortex to contrast sensitivity around the visual field

Himmelberg, M. M.; Winawer, J.; Carrasco, M.

10.1101/2021.10.04.463138 — neuroscience — Posted on 2022-04-25

725 DNA-based detection of Aphanomyces cochlioides in soil and sugar beet plants

Botkin, J. R.; Hirsch, C. D.; Martin, F. N.; Chanda, A. K.

10.1101/2022.04.25.489453 — plant biology — Posted on 2022-04-25

726 The bHLH transcription factor MpHYPNOS is a critical regulator of gemma dormancy in the liverwort Marchantia polymorpha.

Kato, H.; Yoshimura, N.; Yoshikawa, M.; Yasuda, A.; Matsuura, H.; Takahashi, K.; Takezawa, D.; Furuya, T.; Kondo, Y.; Fukaki, H.; Mimura, T.; Ishizaki, K.

10.1101/2022.04.25.488978 — plant biology — Posted on 2022-04-25

727 Spatial organization of Dectin-1 and TLR2 during synergistic crosstalk revealed by super-resolution imaging

Li, M.; Vultorius, C.; Bethi, M.; Yu, Y.

10.1101/2022.04.25.489448 — biophysics — Posted on 2022-04-25

728 Looking at the BiG picture: Incorporating bipartite graphs in drug response prediction

Hostallero, D. E.; Li, Y.; Emad, A.

10.1101/2021.08.11.455993 — bioinformatics — Posted on 2022-04-25

729 Prediction Of The Impact Of Genetic Variability On Drug Sensitivity For Clinically Relevant EGFR Mutations

Surinach, A.; Hospital, A.; Westermaier, Y.; Jorda, L.; Orozco-Ruiz, S.; Beltran, D.; Colizzi, F.; Andrio, P.; Soliva, R.; Municoy, M.; Gelpi, J. L.; Orozco, M.

10.1101/2022.04.25.489389 — biochemistry — Posted on 2022-04-25

730 Functional metagenomic screening in microfluidic droplets identifies a β-glucuronidase in an unprecedented sequence neighbourhood

Neun, S.; Brear, P.; Campbell, E.; Tryfona, T.; El Omari, K.; Wagner, A.; Dupree, P.; Hyvonen, M.; Hollfelder, F.

10.1101/2022.04.25.489410 — biochemistry — Posted on 2022-04-25

731 Molecular Aggregation Induced Photoacoustics for NIR-II in vivo Imaging

Sun, Q.

10.1101/2022.04.25.489363 — biochemistry — Posted on 2022-04-25

732 A novel, NADH-dependent acrylate reductase in Vibrio harveyi

Bertsova, Y. V.; Serebryakova, M.; Baykov, A. A.; Bogachev, A. V.

10.1101/2022.01.20.477176 — biochemistry — Posted on 2022-04-25

733 A Feed-forward Pathway Drives LRRK2 kinaseMembrane Recruitment and Apparent Activation

Vides, E. G.; Adhikari, A.; Lis, P.; Purlyte, E.; Shumate, J. L.; Lasso, E. S.; Dhekne, H. S.; Alessi, D. R.; Pfeffer, S. R.

10.1101/2022.04.25.489459 — biochemistry — Posted on 2022-04-25

734 The whole blood microbiome of Indonesians reveals that environmental differences shape immune gene expression signatures

Bobowik, K. S.; Darusalam, C.; Kusuma, P.; Sudoyo, H.; Febinia, C. A.; Malik, S.; Wells, C.; Gallego Romero, I.

10.1101/2022.04.24.489025 — genomics — Posted on 2022-04-25

735 Culture Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids

Edgar, R. D.; Perrone, F.; Foster, A. R.; Payne, F.; Lewis, S.; Nayak, K. M.; Kraiczy, J.; Cenier, A.; Torrente, F.; Salvestrini, C.; Heuschkel, R.; Hensel, K. O.; Harris, R.; Jones, D. L.; Zerbino, D. R.; Zilbauer, M.

10.1101/2022.04.25.489354 — genomics — Posted on 2022-04-25

736 Anticodon Table of the Chloroplast Genome and Identification of Putative Quadruplet Anticodons in Chloroplast tRNAs

Mohanta, T. K.; Mohanta, Y. K.; Al-Harrasi, A.; Sharma, N.

10.1101/2022.04.24.489293 — genomics — Posted on 2022-04-25

737 SOX15 regulates stem cell pluripotency and promotes neural fate during differentiation by activating Hes5

Choi, E.-B.; Vodnala, M.; Saini, P.; Zerbato, M.; Ho, J. J.; Anugula, S.; Sui, S. H.; Yoon, J.; Inouye, C.; Fong, Y. W.

10.1101/2022.04.25.489402 — cell biology — Posted on 2022-04-25

738 CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells

Geng, K.; Merino, L. G.; Wedemann, L.; Martens, A.; Sobota, M.; Sanchez, Y. P.; Sondergaard, J. N.; White, R. J.; Kutter, C.

10.1101/2021.07.01.450727 — molecular biology — Posted on 2022-04-25

739 FoodMicrobionet v4: a large, integrated, open and transparent database for food bacterial communities

Parente, E.; Zotta, T.; Ricciardi, A.

10.1101/2022.01.19.476946 — microbiology — Posted on 2022-04-25

740 Ancient dental calculus preserves signatures of biofilm succession and inter-individual variation independent of dental pathology

Velsko, I. M.; Semerau, L.; Inskip, S. A.; Garcia-Collado, M. I.; Ziesemer, K.; Serrano Ruber, M.; Benitez de Lugo Enrich, L.; Molero Garcia, J. M.; Gallego Valle, D.; Pena Ruiz, A. C.; Salazar Garcia, D.; Hoogland, M. L.; Warinner, C.

10.1101/2022.04.25.489366 — microbiology — Posted on 2022-04-25

741 The salivary protein Saglin facilitates efficient midgut colonization of Anopheles mosquitoes by malaria parasites

Klug, D.; Gautier, A.; Calvo, E.; Marois, E.; Blandin, S. A.

10.1101/2022.04.25.489337 — microbiology — Posted on 2022-04-25

742 Isoform-specific O-glycosylation dictates Ebola virus infectivity

Bagdonaite, I.; Abdurahman, S.; Mirandola, M.; Narimatsu, Y.; Vakhrushev, S. Y.; Salata, C.; Mirazimi, A.; Wandall, H. H.

10.1101/2022.04.25.489418 — microbiology — Posted on 2022-04-25

743 EEG biomarkers of reduced inhibition in human cortical microcircuits in depression

Mazza, F.; Valiante, T. A.; Griffiths, J. D.; Hay, E.

10.1101/2021.07.18.452836 — neuroscience — Posted on 2022-04-25

744 Immune activation state modulates retrieval of infant engrams

Power, S. D.; Stewart, E.; Zielke, L.; Byrne, E. P.; Ortega-de San Luis, C.; Lynch, L.; Ryan, T. J.

10.1101/2022.04.24.488172 — neuroscience — Posted on 2022-04-25

745 Mapping language and non-language cognitive deficits in post-stroke anomic aphasia

Akkad, H.; Hope, T.; Howland, C.; Ondobaka, S.; Nardo, D.; Pappa, K.; Duncan, J.; Leff, A. P.; Crinion, J.

10.1101/2021.02.15.431293 — neuroscience — Posted on 2022-04-25

746 A parametric logistic equation with light flux and medium concentration for cultivation planning of microalgae

Kambe, K.; Hirokawa, Y.; Koshi, A.; Hori, Y.

10.1101/2022.02.28.482388 — systems biology — Posted on 2022-04-25

747 ACSS2 Regulates HIF-2α Degradation through the E3-Ubiquitin Ligase MUL1 in Clear Cell Renal Cell Carcinoma

Bacigalupa, Z. A.; Brown, W. A.; Krystofiak, E. S.; Wolf, M. M.; Hongo, R. A.; Landis, M.; Amason, E. K.; Beckermann, K. E.; Rathmell, J. C.; Rathmell, W. K.

10.1101/2022.04.21.489116 — cancer biology — Posted on 2022-04-25

748 Stitching and registering highly multiplexed whole slide images of tissues and tumors using ASHLAR

Muhlich, J. L.; Chen, Y.-A.; Yapp, C.; Russell, D. P. W.; Santagata, S.; Sorger, P. K.

10.1101/2021.04.20.440625 — bioinformatics — Posted on 2022-04-25

749 Destructive fishing - A ubiquitously used but vague term? Usage and impacts across academic research, media and policy

Willer, D. F.; Brian, J. I.; Derrick, C.; Walker, J.; Benbow, S.; Brooks, H.; Hazin, C.; McCarthy, A. H.; Mukherjee, N.; McOwen, C.; Steadman, D.

10.1101/2021.05.07.443117 — ecology — Posted on 2022-04-25

750 Canonical Wnt Signaling and the Regulation of Divergent Mesenchymal Fgf8 expression in Axolotl Limb Development and Regeneration

Glotzer, G. L.; Tardivo, P.; Tanaka, E. M.

10.1101/2022.03.28.486111 — developmental biology — Posted on 2022-04-25

751 Memory loss at sleep onset

Lacaux, C.; Andrillon, T.; Arnulf, I.; Oudiette, D.

10.1101/2022.04.25.489361 — neuroscience — Posted on 2022-04-25

752 Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling

Sui, L.; Zhao, Y.; Wang, W.; Chi, H.; Tian, T.; Wu, P.; Zhang, J.; Zhao, Y.; Wei, Z.-K.; Hou, Z.; Zhou, G.; Wang, G.; Wang, Z.; Liu, Q.

10.1101/2022.04.25.489335 — microbiology — Posted on 2022-04-25

753 Sensor NLR immune proteins activate oligomerization of their NRC helper

Contreras, M. P.; Pai, H.; Tumtas, Y.; Duggan, C.; Yuen, E. L. H.; Vergara Cruces, A.; Kourelis, J.; Ahn, H.-K.; Wu, C.-H.; Bozkurt, T. O.; Derevnina, L.; Kamoun, S.

10.1101/2022.04.25.489342 — plant biology — Posted on 2022-04-25

754 The plant nucleoplasmin AtFKBP43 needs its extended arms for histone interaction

Singh, A. K.; Saharan, K.; Baral, S.; Vasudevan, D.

10.1101/2022.04.25.489347 — biophysics — Posted on 2022-04-25

755 Unravelling the mechanisms of adaptation to high pressure in proteins

Calio, A.; Fontanay, S.; Koza, M. M.; Oger, P. M.; Peters, J.

10.1101/2022.04.25.489375 — biophysics — Posted on 2022-04-25

756 SOCS3 limits endotoxin-induced endothelial dysfunction by blocking a required autocrine interleukin 6 signal in human umbilical vein endothelial cells

Martino, N.; Bossardi Ramos, R.; Chuy, D.; Tomaszek, L.; Adam, A. P.

10.1101/2022.04.25.489373 — cell biology — Posted on 2022-04-25

757 A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression

Ghannoum, S.; Fantini, D.; Zahoor, M.; Farhan, V. R.; Phuyal, S.; Netto, W. L.; Sorensen, O.; Iyer, A.; Sengupta, D.; Prasmickaite, L.; Malandsmo, G. M.; Kohn-Luque, A.; Farhan, H.

10.1101/2022.04.25.489358 — cancer biology — Posted on 2022-04-25

758 The small GTPase ARF3 controls metastasis and invasion modality by regulating N-cadherin levels.

Sandilands, E.; Freckmann, E. C.; Roman-Fernandez, A.; McGarry, L.; Galbraith, L.; Mason, S.; Patel, R.; Anand, J.; Cartwright, J.; Leung, H. Y.; Blyth, K.; Bryant, D. M.

10.1101/2022.04.25.489355 — cell biology — Posted on 2022-04-25

759 Generating accurate 3D gaze vectors using synchronized eye tracking and motion capture

Stone, S. A.; Boser, Q. A.; Dawson, T. R.; Vette, A. H.; Hebert, J. S.; Pilarski, P. M.; Chapman, C. S.

10.1101/2021.10.22.465332 — neuroscience — Posted on 2022-04-25

760 Effector-dependent activation and oligomerization of NRC helper NLRs by Rpi-amr3 and Rpi-amr1

Ahn, H.-K.; Lin, X.; Olave-Achury, A. C.; Derevnina, L.; Contreras, M. P.; Kourelis, J.; Kamoun, S.; Jones, J. D.

10.1101/2022.04.25.489359 — plant biology — Posted on 2022-04-25

761 FBXW7β isoform drives transcriptional activation of a proinflammatory TNF cluster in normal and malignant pro-B cells

Yang, S. Y.; Hayer, K. E.; Fazelinia, H.; Asnani, M.; Black, K. L.; Naqvi, A. S.; Pillai, V.; Spruce, L. A.; Barash, Y.; Elenitoba-Johnson, K. S.; Thomas-Tikhonenko, A.

10.1101/2022.04.24.489313 — cell biology — Posted on 2022-04-25

762 Ecology and Conservation status of Phoebe hainesiana Brandis: a data deficit timber species of Indo-Myanmar biodiversity hotspot

Vaishnav, V.; Devajit, Y.; Aashish, L.; Benerjit, W.

10.1101/2022.04.22.489227 — plant biology — Posted on 2022-04-25

763 Opposite polarity programs regulate asymmetric subsidiary cell divisions in grasses

Zhang, D.; Abrash, E. B.; Nunes, T. D.; Hidalgo, I.; Gil, M. X. A.; Jesenofsky, B.; Lindner, H.; Bergmann, D. C.; Raissig, M. T.

10.1101/2022.04.24.489281 — plant biology — Posted on 2022-04-25

764 Identification of genetic markers for the discrimination of Bacillus thuringiensis within the Bacillus cereus group, in the context of foodborne outbreaks

Fichant, A.; Felten, A.; GALLET, A.; Firmesse, O.; Bonis, M.

10.1101/2022.04.22.489186 — bioinformatics — Posted on 2022-04-25

765 LRRK2 Phosphorylates Neuronal Elav RNA-Binding Proteins to RegulatePhenotypes Relevant to Parkinson's Disease

Pastic, A.; Negeri, O.; Ravel-Chapuis, A.; Savard, A.; Trung, M. T.; Palidwor, G.; Guo, H.; Marcogliese, P.; Taylor, J. A.; Okano, H.; Trinkle-Mulcahy, L.; Jasmin, B. J.; Park, D.; Gibbings, D.

10.1101/2022.04.24.489327 — cell biology — Posted on 2022-04-25

Sealey, J. E.; Hammond, A.; Mounsey, O.; Gould, V. C.; Reyher, K. K.; Avison, M. B.

10.1101/2022.04.23.489260 — microbiology — Posted on 2022-04-25

767 First-in-human evaluation of cutaneous innate and adaptive immunomodulation by mosquito bites

Guerrero, D.; Vo, H. T. M.; Lon, C.; Bohl, J. A.; Nhik, S.; Chea, S.; Man, S.; Sreng, S.; Pacheco, A. R.; Ly, S.; Sath, R.; Lay, S.; Misse, D.; Huy, R.; Leang, R.; Kry, H.; Valenzuela, J. G.; Oliveira, F.; Cantaert, T.; Manning, J. E.

10.1101/2022.04.25.489145 — immunology — Posted on 2022-04-25

768 Functional antibodies exhibit light chain coherence

Jaffe, D. B.; Shahi, P.; Adams, B. A.; Chrisman, A. M.; Finnegan, P. M.; Raman, N.; Royall, A. E.; Tsai, F.; Vollbrecht, T.; Reyes, D. S.; McDonnell, W. J.

10.1101/2022.04.23.489267 — immunology — Posted on 2022-04-25

769 The association between working memory precision and the nonlinear dynamics of frontal and parieto-occipital EEG activity.

Chang, W.-S.; Liang, W.-K.; Li, D.-H.; Muggleton, N. G.; Balachandran, P.; Huang, N. E.; Juan, C.-H.

10.1101/2022.04.24.489284 — neuroscience — Posted on 2022-04-25

770 Decoding reward-curiosity conflict in decision-making from irrational behaviors

Konaka, Y.; Naoki, H.

10.1101/2022.04.24.489304 — neuroscience — Posted on 2022-04-25

771 From the ear flap to the nerve: A complete computer model of the peripheral auditory system

Tichacek, O.; Mistrik, P.; Jungwirth, P.

10.1101/2022.04.23.489223 — neuroscience — Posted on 2022-04-25

772 Unlocking the microblogging potential for science and medicine

Sarkar, A.; Giros, A.; Mockly, L.; Moore, J.; Moore, A.; Nagareddy, A.; Patel, Y.; Chhugani, K.; Sarwal, V.; Darci-Maher, N.; Chang, Y.; Garmire, L. X.; Bao, R.; Chikhi, R.; Mangul, S.

10.1101/2022.04.22.488804 — scientific communication and education — Posted on 2022-04-25

773 Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

Bartholf DeWitt, S.; Hoskinson Plumlee, S.; Brighton, H. E.; Sivaraj, D.; Martz, E. J.; Zand, M.; Kumar, V.; Sheth, M. U.; Floyd, W.; Spruance, J.; Hawkey, N.; Varghese, S.; Ruan, J.; Kirsch, D. G.; Somarelli, J.; Alman, B.; Eward, W. C.

10.1101/2022.04.22.489086 — cancer biology — Posted on 2022-04-25

774 DeepTMB: An uncertainty-aware deep calibration of tumor mutational burden with a synthetic tumor-only dataset

Anaya, J.; Baras, A. S.

10.1101/2022.04.22.489230 — bioinformatics — Posted on 2022-04-25

775 Direct N-Me Aziridination Reaction Enables Pinpointing C=C Bonds in Lipids with Mass Spectrometry

Feng, G.; Gao, M.; Fu, R.; Wan, Q.; Wang, T.; Zhang, Z.; Chen, S.

10.1101/2022.04.24.489320 — biochemistry — Posted on 2022-04-25

776 Structural variants in the barley gene pool: precision and sensitivity to detect them using short-read sequencing and their association with gene expression and phenotypic variation

Weisweiler, M.; Arlt, C.; Wu, P.-Y.; Van Inghelandt, D.; Hartwig, T.; Stich, B.

10.1101/2022.04.25.489331 — genomics — Posted on 2022-04-25

777 Robust analysis of prokaryotic pangenome gene gain and loss rates with Panstripe

Tonkin-Hill, G.; Gladstone, R. A.; Pontinen, A. K.; Arredondo-Alonso, S.; Bentley, S. D.; Corander, J.

10.1101/2022.04.23.489244 — evolutionary biology — Posted on 2022-04-25

778 Jointly analyzing the association of human milk nutrients with cognition and temperament traits during the first 6 months of life

Li, T.; Samuel, T. M.; Zhu, Z.; Howell, B.; Cho, S.; Baluyot, K.; Hazlett, H.; Elison, J. T.; Wu, D.; Hauser, J.; Sprenger, N.; Zhu, H.; Lin, W.

10.1101/2022.04.24.489325 — developmental biology — Posted on 2022-04-25

779 Genome-wide translocation events drive the evolution of Candida africana

Nnadi, N. E.; Giosa, D.; Izam, Y.; Ubani, A.; Ngene, A.; Ayanbimpe, G. M.; Enweani-Nwokelo, I. B.; Aguiyi, J. C.

10.1101/2022.04.23.489250 — microbiology — Posted on 2022-04-25

780 Toward Interpretable Digital Biomarkers of Walking and Reaching in Parkinson's Disease

Ryu, J.; Torres, E. B.

10.1101/2022.04.23.489070 — neuroscience — Posted on 2022-04-25

781 The language network reliably 'tracks' naturalistic meaningful non-verbal stimuli

Sueoka, Y.; Paunov, A.; Ivanova, A.; Blank, I. A.; Fedorenko, E.

10.1101/2022.04.24.489316 — neuroscience — Posted on 2022-04-25

782 Precise temporal control of GEVI conformations enables the visualization of charge migration in a fluorescent protein resulting in an improved optical response

Leong, L. M.; Rhee, J. K.; Kim, H.; Seong, J.; Woo, J.; Han, K.; Storace, D. A.; Baker, B. J.

10.1101/2022.04.25.489330 — neuroscience — Posted on 2022-04-25

783 The structural basis of long-term potentiation in hippocampal synapses, revealed by EM-imaging of lanthanum-induced synaptic vesicle recycling

Heuser, J.

10.1101/2022.04.22.489201 — neuroscience — Posted on 2022-04-25

784 A Computational Theory of Learning Flexible Reward-Seeking Behavior with Place Cells

Gao, Y.

10.1101/2022.04.23.489289 — neuroscience — Posted on 2022-04-25

785 Engineered gene circuits with reinforcement learning allow bacteria to master gameplaying

Racovita, A.; Prakash, S.; Varela, C.; Walsh, M.; Galizi, R.; Isalan, M.; Jaramillo, A.

10.1101/2022.04.22.489191 — synthetic biology — Posted on 2022-04-25

786 Comparison of dry and wet electrodes for detecting gastrointestinal activity patterns from body surface electrical recordings

Erickson, J. C.; Stepanyan, E.; Hassid, E.

10.1101/2022.04.23.489246 — bioengineering — Posted on 2022-04-25

787 Quaternary Ammonium Salt-Modified Isabgol (Psyllium) Scaffold as an Antibacterial Dressing for Improved Wound Healing

TK, V.; Patel, A. K.; Muthuvijayan, V.

10.1101/2022.04.24.489269 — bioengineering — Posted on 2022-04-25

788 Fine-mapping from summary data with the "Sum of Single Effects" model

Zou, Y.; Carbonetto, P.; Wang, G.; Stephens, M.

10.1101/2021.11.03.467167 — genetics — Posted on 2022-04-25

789 Honey bee functional genomics using symbiont-mediated RNAi

Lariviere, P. J.; Leonard, S. P.; Horak, R. D.; Powell, J. E.; Barrick, J. E.

10.1101/2022.04.22.489157 — genetics — Posted on 2022-04-25

790 Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

Kopal, J.; Kumar, K.; Saltoun, K.; Modenato, C.; Moreau, C. A.; Martin-Brevet, S.; Huguet, G.; Jean-Louis, M.; Martin, C.-O.; Saci, Z.; Younis, N.; Tamer, P.; Douard, E. A.; Maillard, A.; Rodriguez-Herreros, B.; Pain, A.; Richetin, S.; Kushan, L.; Silva, A. I.; van den Bree, M. B.; Linden, D. E.; Owen, M. J.; Hall, J.; Lippe, S.; Draganski, B.; Sonderby, I. E.; Andreassen, O. A.; Glahn, D. C.; Thompson, P.; Bearden, C. E.; Jacquemont, S.; Bzdok, D.

10.1101/2022.04.23.489093 — genetics — Posted on 2022-04-25

791 Cultural specialization as a double-edged sword: division into specialized guilds might promote cultural complexity at the cost of higher susceptibility to cultural loss

Ben-Oren, Y.; Kolodny, O.; Creanza, N.

10.1101/2022.04.22.489202 — evolutionary biology — Posted on 2022-04-25

792 The Devil Is In The Details: Landscape Features Are Insufficient To Explain Patterns Of Non-Native Fishes Distribution In North Patagonian Streams

Lallement, M. E.; Rechencq, M.; Zattara, E. E.

10.1101/2022.04.24.489319 — ecology — Posted on 2022-04-25

793 Mapping the risks of China's global coastal development to marine socio-ecological systems

Simmons, B. A.; Butt, N.; O'Hara, C. C.; Ray, R.; Ma, Y.; Gallagher, K. P.

10.1101/2022.04.22.489174 — ecology — Posted on 2022-04-25

794 Intrauterine inflammation leads to some sex and age-specific behavior and molecular differences in mice

Cristancho, A. G.; Tulina, N.; Anton, L.; Barila, G.; Elovitz, M. A.

10.1101/2022.04.24.486005 — developmental biology — Posted on 2022-04-25

795 EggVio: a user friendly and versatile pipeline for assembly and functional annotation of shallow depth sequenced samples

Bergk Pinto, B. M.; Vogel, T. M.; Larose, C.

10.1101/2022.04.23.489251 — microbiology — Posted on 2022-04-25

796 Advancing antimicrobial resistance monitoring in surface waters with metagenomic and quasimetagenomic methods

Ottesen, A.; Kocurek, B.; Ramachandran, P.; Reed, E.; Commichaux, S.; Engelbach, G.; Mammel, M.; Saint Fleurant, S.; Zhao, S.; Kabera, C.; Merrill, A.; Bonin, N.; Worley, H.; Noyes, N.; Boucher, C.; McDermott, P. F.; Strain, E.

10.1101/2022.04.22.489054 — microbiology — Posted on 2022-04-25

797 Altered basal ganglia output during self-restraint

Gu, B.-M.; Berke, J. D.

10.1101/2022.04.23.489276 — neuroscience — Posted on 2022-04-25

798 Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin

Osipiuk, J.; Wydorski, P. M.; Lanham, B. T.; Tesar, C.; Endres, M.; Engle, E.; Jedrzejczak, R.; Mullapudi, V.; Michalska, K.; Fidelis, K.; Fushman, D.; Joachimiak, A.; Joachimiak, L. A.

10.1101/2021.09.15.460543 — biophysics — Posted on 2022-04-25

799 Using large soybean historical data to study genotype by environment variation and identify mega-environments with the integration of genetic and non-genetic factors

Dalsente Krause, M.; Olimpio das Gracas Dias, K.; Singh, A. K.; Beavis, W. D.

10.1101/2022.04.11.487885 — genetics — Posted on 2022-04-25

800 Confronting population models with experimental microcosm data: from trajectory matching to state-space models

Rosenbaum, B.; Fronhofer, E. A.

10.1101/2021.09.13.460028 — ecology — Posted on 2022-04-25

801 Brain-to-brain concordance in child-parent dyads underlies children's psychological wellbeing

Su, H.; Young, C. B.; Han, Z. R.; Xu, J.; Xiong, B.; Wang, J.; Hao, L.; Yang, Z.; Chen, G.; Qin, S.

10.1101/2022.03.30.486310 — neuroscience — Posted on 2022-04-25

802 Automated slice-specific z-shimming for fMRI of the human spinal cord

Kaptan, M.; Vannesjo, S. J.; Mildner, T.; Horn, U.; Hartley-Davies, R.; Oliva, V.; Brooks, J. C. W.; Weiskopf, N.; Finsterbusch, J.; Eippert, F.

10.1101/2021.07.27.454049 — neuroscience — Posted on 2022-04-25

803 A nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an olfactory chemoattractant for the grass puffer

Noguchi, Y.; Suzuki, T.; Matsutani, K.; Sakakibara, R.; Nakahigashi, R.; Adachi, M.; Nishikawa, T.; Abe, H.

10.1101/2021.09.12.459881 — zoology — Posted on 2022-04-25

804 Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations

Hemez, C.; Clarelli, F.; Palmer, A. C.; Chindelevitch, L.; Cohen, T.; Abel zur Wiesch, P.

10.1101/2020.06.01.127571 — pharmacology and toxicology — Posted on 2022-04-25

805 Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations

Hemez, C.; Clarelli, F.; Palmer, A. C.; Chindelevitch, L.; Cohen, T.; Abel zur Wiesch, P.

10.1101/2020.06.01.127571 — pharmacology and toxicology — Posted on 2022-04-25

806 Condensation of the influenza viral fusion peptide alters membrane structure and water permeability

Rice, A.; Haldar, S.; Wang, E.; Blank, P. S.; Akimov, S. A.; Galimzyanov, T. R.; Pastor, R. W.; Zimmerberg, J.

10.1101/2021.08.09.455689 — biophysics — Posted on 2022-04-25

807 A systematic examination of learning in the invasive ant Linepithema humile reveals very rapid development of short and long-term memories

Wagner, T.; Galante, H.; Czaczkes, T. J.

10.1101/2022.04.12.487867 — animal behavior and cognition — Posted on 2022-04-25

808 pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo

Rumley, J. D.; Preston, E. A.; Cook, D.; Peng, F. L.; Zacharias, A. L.; Wu, L.; Jileaeva, I.; Murray, J. I.

10.1101/2021.12.14.472681 — genetics — Posted on 2022-04-25

809 Atlantic cod as an indicator of rapid climate change

Choi, J. S.

10.1101/2022.04.21.488963 — ecology — Posted on 2022-04-25

810 Modified MRI anonymization (de-facing) for improved MEG coregistration

Bruna, R.; Vaghari, D.; Greve, A.; Cooper, E.; Mada, M. M.; Henson, R. N.

10.1101/2022.04.20.488466 — molecular biology — Posted on 2022-04-25

811 Peptidoglycan maturation controls spatiotemporal organisation of outer membrane proteins in Escherichia coli

Mamou, G.; Corona, F.; Cohen-Khait, R.; Sun, D.; Sridhar, P.; Pazos, M.; Knowles, T. J.; Kleanthous, C.; Vollmer, W.

10.1101/2022.04.11.487844 — microbiology — Posted on 2022-04-25

812 Genetic control of neuronal activity enhances axonal growth only on permissive substrates

Mesquida-Veny, F.; Martinez-Torres, S.; del Rio, J. A.; Hervera Abad, A.

10.1101/2022.01.21.477184 — neuroscience — Posted on 2022-04-25

813 Numerical methods for the detection of phase defect structures in excitable media

Kabus, D.; Arno, L.; Leenknegt, L.; Panfilov, A. V.; Dierckx, H.

10.1101/2021.12.16.473086 — systems biology — Posted on 2022-04-25

814 Correlations from structure and phylogeny combine constructively in the inference of protein partners from sequences

Gerardos, A.; Dietler, N.; Bitbol, A.-F.

10.1101/2021.11.22.469574 — bioinformatics — Posted on 2022-04-25

815 Decoding rRNA Sequences for Improved Metagenomics in Sylvatic Mosquito Species

Koh, C.; Frangeul, L.; Blanc, H.; Ngoagouni, C.; Boyer, S.; Dussart, P.; Grau, N.; Girod, R.; Duchemin, J.-B.; Saleh, M.-C.

10.1101/2022.02.01.478639 — bioinformatics — Posted on 2022-04-25

816 A graph-embedded topic model enables characterization of diverse pain phenotypes among UK Biobank individuals

Wang, Y.; Benavides, R.; Diatchenko, L.; Grant, A.; Li, Y.

10.1101/2022.01.07.475444 — bioinformatics — Posted on 2022-04-25

817 Small-amplitude head oscillations result from a multimodal head stabilization reflex in hawkmoths

Chatterjee, P.; Mohan, U.; Sane, S. P.

10.1101/2022.04.24.489321 — neuroscience — Posted on 2022-04-25

818 Absolute quantitation of serum antibody reactivity using the Richards growth model for antigen microspot titration

Papp, K.; Kovacs, A.; Orosz, A.; Herincs, Z.; Randek, J.; Liliom, K.; Pfeil, T.; Prechl, J.

10.1101/2021.10.28.466238 — immunology — Posted on 2022-04-25

819 Landscapes of transposable elements in Apis species by meta-analysis

Yokoi, K.; Kimura, K.; Bono, H.

10.1101/2020.04.15.035063 — bioinformatics — Posted on 2022-04-25

820 Do males know? Evidence-driven rainmaking mating strategy by male bonobos to meet the fertile window of females

Ryu, H.; Hashimoto, C.; Hill, D. A.; Mouri, K.; Shimizu, K.; Furuichi, T.

10.1101/2022.03.13.483391 — animal behavior and cognition — Posted on 2022-04-25

821 Potential geographic distribution and ecological niche of New World dobsonflies (Megaloptera, Corydalidae): the case of the Neartic-Neotropical transition zone

Alvarez, H. A.; Rivas-Soto, M. A.

10.1101/2022.01.01.474714 — ecology — Posted on 2022-04-25

822 Two functionally distinct heme/iron transport systems are virulence determinants of the fish pathogen Flavobacterium psychrophilum

Zhu, Y.; Lechardeur, D.; Bernardet, J.-F.; Kerouault, B.; Guerin, C.; Rigaudeau, D.; Nicolas, P.; Duchaud, E.; Rochat, T.

10.1101/2022.04.04.486927 — microbiology — Posted on 2022-04-25

823 A neuromodulatory model for determining the effect of emotion-respiration-cognition coupling on the time-to-respond

Yonekura, S.; Cueto, J.; Kanazawa, H.; Atsumi, N.; Hirabayashi, S.; Iwamoto, M.; Kuniyoshi, Y.

10.1101/2022.03.30.486453 — neuroscience — Posted on 2022-04-25

824 A dynamic spike threshold with correlated noise predicts observed patterns of negative interval correlations in neuronal spike trains

Sidhu, R. S.; Johnson, E. C.; Jones, D. L.; Ratnam, R.

10.1101/2020.11.30.403725 — neuroscience — Posted on 2022-04-25

825 Critical periods when dopamine controls behavioral responding during Pavlovian learning

Lefner, M.; Stelly, C. E.; Zurita, H.; Fonzi, K. M.; Wanat, M.

10.1101/2022.02.28.482312 — neuroscience — Posted on 2022-04-25

826 Growth rate controls the sensitivity of gene regulatory circuits

Julou, T.; Gervais, T.; van Nimwegen, E.

10.1101/2022.04.03.486858 — systems biology — Posted on 2022-04-25

827 Phylogroup-specific variation shapes pangenome dynamics in Pseudomonas aeruginosa

Botelho, J.; Tüffers, L.; Fuss, J.; Buchholz, F.; Utpatel, C.; Klockgether, J.; Niemann, S.; Tümmler, B.; Schulenburg, H.

10.1101/2022.04.24.489302 — microbiology — Posted on 2022-04-24

828 Homogeneous inhibition is optimal for the phase precession of place cells in the CA1 field

Vandyshev, G.; Mysin, I. E.

10.1101/2022.04.24.489307 — neuroscience — Posted on 2022-04-24

829 Mechanisms and functions of respiration-driven gamma oscillations in the piriform cortex

Gonzalez, J.; Torterolo, P.; Tort, A. B.

10.1101/2022.04.24.489324 — neuroscience — Posted on 2022-04-24

830 Immune activation state modulates retrieval of infant engrams

Power, S. D.; Stewart, E.; Zielke, L.; Byrne, E. P.; Ortega-de San Luis, C.; Lynch, L.; Ryan, T. J.

10.1101/2022.04.24.488172 — neuroscience — Posted on 2022-04-24

831 Unlocking the strength of inducible promoters in gram-negative bacteria

Carrillo Rincon, A. F.; Farny, N. G.

10.1101/2022.04.23.489285 — synthetic biology — Posted on 2022-04-24

832 Regulation of metabolic health by dietary histidine in mice

Flores, V.; Spicer, A. B.; Sonsalla, M.; Richardson, N. E.; Yu, D.; Sheridan, G. E.; Trautman, M. E.; Babygirija, R.; Cheng, E. P.; Rojas, J. M.; Yang, S. E.; Wakai, M. H.; Hubbell, R.; Kasza, I.; Tomasiewicz, J. L.; Green, C. L.; Dantoin, C.; Alexander, C. M.; Baur, J. A.; Malecki, K. C.; Lamming, D.

10.1101/2022.04.24.489217 — physiology — Posted on 2022-04-24

833 ALDH2 DEFICIENCY INCREASES SUSCEPTIBILITY TO BINGE ALCOHOL-INDUCED GUT LEAKINESS, ENDOTOXEMIA, AND ACUTE LIVER INJURY IN MICE THROUGH THE GUT-LIVER AXIS

Rungratanawanich, W.; Wang, X.; Kawamoto, T.; Chidambaram, S. B.; Song, B.-J.

10.1101/2022.04.23.489282 — pharmacology and toxicology — Posted on 2022-04-24

834 Identifying Proteasome 26S Subunit, ATPase (PSMC) Family Genes as the Prognostic Indicators and Therapeutic Targets in Lung Adenocarcinoma

Ullah, M. A.; Islam, N. N.; Moin, A. T.; Park, S. H.; Kim, B.

10.1101/2022.04.23.489290 — cancer biology — Posted on 2022-04-24

835 Detection of local growth patterns in longitudinally imaged low-grade gliomas

Gui, C.; Kai, J.; Khan, A. R.; Lau, J. C.; Megyesi, J. F.

10.1101/2022.04.24.488099 — cancer biology — Posted on 2022-04-24

836 Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS

Ilter, M.; Kasmer, R.; Jalalypour, F.; Atilgan, C.; Topcu, O.; Karakas, N.; Sensoy, O.

10.1101/2022.04.24.489309 — cancer biology — Posted on 2022-04-24

837 Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability

Murphy, R. J.; Gunasingh, G.; Haass, N. K.; Simpson, M. J.

10.1101/2022.04.24.489294 — cancer biology — Posted on 2022-04-24

838 MICOS Complex and Mitochondria Morphology Changes Across Aging in Cardiac Muscle

Vue, Z.; Garza Lopez, E.; Neikirk, K.; Vang, L.; Beasley, H.; Crabtree, A.; Marshall, A.; Murray, S. A.; Hinton, A.

10.1101/2022.04.23.489291 — biophysics — Posted on 2022-04-24

839 An evolutionary perspective on the origin, conservation and binding partner acquisition of tankyrases

Sowa, S. T.; Bosetti, C.; Galera-Prat, A.; Johnson, M. S.; Lehtiö, L.

10.1101/2022.04.24.489311 — bioinformatics — Posted on 2022-04-24

840 Mutually exclusive spectral biclustering and its applications in cancer subtyping

Liu, F.; Yang, Y.; Xu, X. S.; Yuan, M.

10.1101/2022.04.24.489301 — bioinformatics — Posted on 2022-04-24

841 Portable low-cost macroscopic mapping system for all-optical cardiac electrophysiology

Heinson, Y.; Han, J. L.; Entcheva, E.

10.1101/2022.04.24.489308 — bioengineering — Posted on 2022-04-24

842 Direct Visualization of Translesion DNA Synthesis Polymerase IV at the Replisome

Pham, T. M.; Marians, K. J.; Kowalczykowski, S. C.

10.1101/2022.04.23.489275 — biochemistry — Posted on 2022-04-24

843 Molecular and functional characterization of the Drosophila melanogaster conserved smORFome

Bosch, J. A.; Keith, N.; Escobedo, F.; Fisher, W. F.; LaGraff, J. T.; Rabasco, J.; Wan, K.; Weiszmann, R.; Hu, Y.; Kondo, S.; Brown, J. B.; Perrimon, N.; Celniker, S. E.

10.1101/2022.04.24.489283 — genomics — Posted on 2022-04-24

844 A novel de novo FEM1C variant as a potential cause of neurodevelopmental disorder with absent speech, pyramidal signs, and limb ataxia.

Dubey, A. A.; Krygier, M.; Szulc, N. A.; Rutkowska, K.; Kosinska, J.; Pollak, A.; Rydzanicz, M.; Kmiec, T.; Mazurkiewicz-Beldzinska, M.; Pokrzywa, W.; Ploski, R.

10.1101/2022.04.24.489208 — genetics — Posted on 2022-04-24

845 Evolutionary analysis of p38 stress activated kinases in unicellular relatives of animals suggests an ancestral function in osmotic stress

Shabardina, V.; Charria, P. R.; Saborido, G. B.; Mora, E. D.; Cuenda, A.; Trillo, I. R.; Ezquerro, J. J. S.

10.1101/2022.04.24.489300 — evolutionary biology — Posted on 2022-04-24

846 GNL3 is an evolutionarily-conserved stem cell gene influencing cell proliferation, animal growth, and regeneration in the hydrozoan Hydractinia

Quiroga-Artigas, G.; de Jong, D.; Schnitzler, C.

10.1101/2022.04.24.489303 — evolutionary biology — Posted on 2022-04-24

847 Growth phase estimation for abundant bacterial populations sampled longitudinally from human stool metagenomes.

Lim, J. J.; Diener, C.; Gibbons, S. M.

10.1101/2022.04.23.489288 — ecology — Posted on 2022-04-24

848 Functional Comparison Between Endogenous and Synthetic Notch Systems

Khamaisi, B.; Luca, V. C.; Blacklow, S. C.; Sprinzak, D.

10.1101/2022.04.24.489295 — molecular biology — Posted on 2022-04-24

849 Mircubactin B rescues the lethal effect of cell wall biosynthesis mutations in Bacillus subtilis.

Kepplinger, B.; Wen, X.; Tyler, A. R.; Kim, B.-Y.; Brown, J.; Banks, P.; Dashti, Y.; Mackenzie, E. S.; Wills, C.; Kawai, Y.; Waldron, K. J.; Allenby, N. E. E.; Wu, L. J.; Hall, M. J.; Errington, J.

10.1101/2022.04.24.489322 — microbiology — Posted on 2022-04-24

850 Immune Checkpoint Activity Regulates Polycystic Kidney Disease Progression

Kleczko, E. K.; Nguyen, D. T.; Marsh, K. H.; Bauer, C. D.; Li, A. S.; Furgeson, S. B.; Gitomer, B. Y.; Chonchol, M. B.; Clambey, E. T.; Zimmerman, K. A.; Nemenoff, R. A.; Hopp, K.

10.1101/2022.04.24.489306 — immunology — Posted on 2022-04-24

851 Combined measurements of proteome and cell turnover reveal the influences of tissue context and pathological aging on protein and organelle lifetimes

Hasper, J.; Welle, K. A.; Hryhorenko, J.; Ghaemmaghami, S.; Buchwalter, A.

10.1101/2022.04.24.488979 — systems biology — Posted on 2022-04-24

852 sgcocaller and comapr: personalised haplotype assembly and comparative crossover map analysis using single-gamete sequencing data

Lyu, R.; Tsui, V.; Crismani, W.; Liu, R.; Shim, H.; McCarthy, D. J.

10.1101/2022.02.10.479822 — bioinformatics — Posted on 2022-04-24

853 An analytical solution simulating growth of Lewy bodies

Kuznetsov, I. A.; Kuznetsov, A. V.

10.1101/2021.12.22.473938 — bioengineering — Posted on 2022-04-24

854 Copy number-aware deconvolution of tumor-normal DNA methylation profiles

Larose Cadieux, E.; Mensah, N. E.; Castignani, C.; Tanic, M.; Wilson, G. A.; Dietzen, M.; Dhami, P.; Vaikkinen, H.; Verfaillie, A.; Cotobal Martin, C.; Baker, T.; Watkins, T. B. K.; Veeriah, S.; Jamal-Hanjani, M.; Kanu, N.; McGranahan, N.; Feber, A.; TRACERx Consortium, ; Swanton, C.; Beck, S.; Demeulemeester, J.; Van Loo, P.

10.1101/2020.11.03.366252 — genomics — Posted on 2022-04-24

855 Partitioning the temporal changes in abundance-based beta diversity into loss and gain components

Tatsumi, S.; Iritani, R.; Cadotte, M. W.

10.1101/2021.05.28.446095 — ecology — Posted on 2022-04-24

856 Divergent acute versus prolonged in vivo GLP-1R responses in β-arrestin 2-deleted primary beta cells

Bitsi, S.; Manchanda, Y.; ElEid, L.; Mohamed, N.; Hansen, B.; Suba, K.; Rutter, G. A.; Salem, V.; Jones, B.; Tomas, A.

10.1101/2022.04.21.489075 — cell biology — Posted on 2022-04-24

857 ORIGIN OF THREE RELATED MOVEMENT GENE MODULES IN PLANT VIRUSES: EVOLUTIONARY RADIATIONS OF BENYVIRUS-LIKE RNA REPLICONS

Morozov, S.; Solovyev, A. G.

10.1101/2022.01.19.477018 — microbiology — Posted on 2022-04-24

858 Flexible utilization of spatial- and motor-based codes for the storage of visuo-spatial information

Henderson, M. M.; Rademaker, R. L.; Serences, J. T.

10.1101/2021.07.08.451663 — neuroscience — Posted on 2022-04-24

859 GABA facilitates spike propagation through branch points of sensory axons in the spinal cord

Hari, K.; Lucas-Osma, A. M.; Metz, K.; Lin, S.; Pardell, N.; Roszko, D.; Black, S.; Minarik, A.; Singla, R.; Stephens, M. J.; Pearce, R. A.; Fouad, K.; Jones, K. E.; Gorassini, M. A.; Fenrich, K. K.; Li, Y.; Bennett, D. J.

10.1101/2021.01.20.427494 — neuroscience — Posted on 2022-04-24

860 Functional resilience of mutually repressing motifs embedded in larger regulatory networks

Harlapur, P.; Duddu, A. S.; Hari, K.; Jolly, M. K.

10.1101/2022.01.13.475824 — systems biology — Posted on 2022-04-24

861 Saturation mutagenesis of a predicted ancestral Syk-family kinase

Hobbs, H. T.; Shah, N. H.; Shoemaker, S. R.; Amacher, J. F.; Marqusee, S.; Kuriyan, J.

10.1101/2022.04.24.489292 — biochemistry — Posted on 2022-04-24

862 Cryo-electron tomography of the apicomplexan invasion machinery in its native state reveals rigid body motion of the conoid and docked secretory machinery

Gui, L.; O'Shaughnessy, W. J.; Cai, K.; Reetz, E.; Reese, M. L.; Nicastro, D.

10.1101/2022.04.23.489287 — biophysics — Posted on 2022-04-24

863 Projective LDDMM: Mapping Molecular Digital Pathology with Tissue MRI

Stouffer, K.; Witter, M.; Tward, D. J.; Miller, M. I.

10.1101/2022.04.22.489163 — bioengineering — Posted on 2022-04-24

864 Vinculin plays a role in neutrophil stiffening and transit through model capillary segments

Neumann, B. M.; Wilson, Z. S.; Auguste, K.; Roye, Y.; Shah, M. K.; Darling, E. M.; Lefort, C. T.

10.1101/2022.04.24.489286 — cell biology — Posted on 2022-04-24

865 Proteostatic regulation of caveolins avoids premature oligomerisation and preserves ER homeostasis

Morales-Paytuvi, F.; Ruiz-Mirapeix, C.; Fajardo, A.; Rae, J.; Bosch, M.; Enrich, C.; Collins, B.; Parton, R. G.; Pol, A.

10.1101/2022.04.24.489297 — cell biology — Posted on 2022-04-24

866 Placental mammal derived microRNAs alter pathways in the endometrial epithelia important for endometrial function.

Hume, L.; Edge, J. C.; Tinning, H.; Wang, D.; Taylor, A. S.; Ovchinnikov, V.; Geijer-Simpson, A.; Brosens, J.; Lucas, E. S.; Simson, N. A. B.; Shillito, J.; Forbes, K.; O'Connell, M. J.; Forde, N.

10.1101/2022.04.23.489270 — cell biology — Posted on 2022-04-24

867 Every individual makes a difference: A trinity derived from linking individual brain morphometry, connectivity and mentalising ability

Li, Z.; Dong, Q.; Hu, B.; Wu, H.

10.1101/2022.04.11.487870 — neuroscience — Posted on 2022-04-24

868 Short latency stretch reflexes depend on the balance of activity in agonist and antagonist muscles during ballistic elbow movements

Villamar, Z.; Ludvig, D.; Perreault, E. J.

10.1101/2021.12.06.471376 — neuroscience — Posted on 2022-04-23

869 Multi-omics investigation of tacrolimus nephrotoxicity

AOUAD, H.; FAUCHER, Q.; SAUVAGE, F.-L.; PINAULT, E.; BARROT, C.-C.; ARNION, H.; MARQUET, P.; ESSIG, M.

10.1101/2021.07.29.454229 — pharmacology and toxicology — Posted on 2022-04-24

870 STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models

Berger, G.; Knelson, E. H.; Jimenez-Macias, J. L.; Nowicki, M. O.; Han, S.; Lizotte, P. H.; Adu-Berchie, K.; Stafford, A.; Dimitrikakis, N.; Chiocca, E. A.; Mooney, D. J.; Barbie, D. A.; Lawler, S. E.

10.1101/2022.02.28.481908 — cancer biology — Posted on 2022-04-24

871 We get by with a little help from our friends: shared adaptive variation provides a bridge to novel ecological specialists during adaptive radiation

Richards, E.; Martin, C. H.

10.1101/2021.07.01.450755 — evolutionary biology — Posted on 2022-04-23

872 The role of TGFβ signaling in Gli1+ tendon and enthesis cells

Song, L.; Golman, M.; Abraham, A. C.; Zelzer, E.; Thomopoulos, S.

10.1101/2022.03.03.482926 — developmental biology — Posted on 2022-04-23

873 A Chalcone Synthase-Like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells

Gulsan, E. E.; Nowshad, F.; Leigh, M. D.; Cross, J. W.; Safe, S.; Jayaraman, A.; Lee, K.

10.1101/2022.04.22.489210 — microbiology — Posted on 2022-04-23

874 Parallel systems for social and spatial reasoning within the cortical apex

Deen, B.; Freiwald, W. A.

10.1101/2021.09.23.461550 — neuroscience — Posted on 2022-04-23

875 The dorsal visual pathway represents object-centered spatial relations for object recognition

Ayzenberg, V.; Behrmann, M.

10.1101/2021.11.12.468414 — neuroscience — Posted on 2022-04-23

876 3D Reconstructions of Mouse Skeletal Muscle Reveal a Decrease in the MICOS Complex and Altered Mitochondrial Networks

Vue, Z.; Lopez, E. G.; Neikirk, K.; Vang, L.; Beasley, H.; Crabtree, A.; Marshall, A.; Murray, S.; Hinton, A.

10.1101/2022.03.22.485341 — biophysics — Posted on 2022-04-23

877 cvlr: Finding heterogeneously methylated genomicregions using ONT reads

Raineri, E.; Alberola, M.; Dabad, M.; Heath, S. C.

10.1101/2022.04.19.488395 — bioinformatics — Posted on 2022-04-23

878 Anatomical and Palynological Investigation within flora of Family Asteraceae

Shahzad, A.; Iqbal, S.; Kayani, S.; Shafiq, T.; Zafar, M.; Naeem, M.; Yasmin, H.

10.1101/2022.04.22.489184 — plant biology — Posted on 2022-04-23

879 Genetic elements orchestrating Lactobacillus crispatus glycogen metabolism in the vagina

Hertzberger, R. Y.; May, A.; Kramer, G.; van Vondelen, I.; Molenaar, D.; Kort, R.

10.1101/2022.04.23.489263 — microbiology — Posted on 2022-04-23

880 A retrospective molecular investigation of selected pigeon viruses between 2018-2021 in Turkey

Sahindokuyucu, I.; Yazici, Z.; Barry, G.

10.1101/2022.04.22.489161 — microbiology — Posted on 2022-04-23

881 Green emitting carbon quantum dots (GCQDs) to probe endocytic pathways in cells; for tissue and in vivo bioimaging

Yadav, P.; Shah, K.; Kansara, K.; Das, S.; Kumar, A.; Rawal, R.; Bhatia, D. D.

10.1101/2022.04.23.489248 — bioengineering — Posted on 2022-04-23

882 Identification of Transient Intermediates During Spliceosome Activation by Single Molecule Fluorescence Microscopy

Fu, X.; Kaur, H.; Rodgers, M. L.; Montemayor, E.; BUTCHER, S. E.; Hoskins, A.

10.1101/2022.04.23.488636 — biochemistry — Posted on 2022-04-23

883 5' transgenes drive leaky expression of 3' transgenes in inducible bicistronic vectors

Osanai, Y.; Xing, L.; Kobayashi, K.; Homman-Ludiye, J.; Cooray, A.; Poh, J.; Ohno, N.; Merson, T. D.

10.1101/2022.04.23.489261 — molecular biology — Posted on 2022-04-23

884 Expression of the Bacillus thuringiensis vip3A insecticidal toxin gene is activated at the onset of stationary phase by VipR, an autoregulated transcription factor

Chen, H.; Verplaetse, E.; Slamti, L.; Lereclus, D.

10.1101/2022.04.23.489259 — microbiology — Posted on 2022-04-23

885 A rapid and universal liquid chromatograph-mass spectrometry-based platform, refmAb-Q nSMOL, for monitoring monoclonal antibody therapeutics

Iwamoto, N.; Koguchi, Y.; Yokoyama, K.; Hamada, A.; Yonezawa, A.; Piening, B. D.; Tran, E.; Fox, B. A.; Redmond, W. L.; Shimada, T.

10.1101/2022.04.22.489238 — immunology — Posted on 2022-04-23

886 TFIIF interacts with the Topoisomerase VI complex and selectively controls the expression of genes encoding PPR proteins involved in organellar RNA editing in Arabidopsis.

Dimnet, L.; Vriet, C.; Achard, D.; Lecampion, C.; Breuer, C.; Soubigou-Taconnat, L.; Sugimoto, K.; Delannoy, E.; Laloi, C.

10.1101/2022.04.23.489258 — plant biology — Posted on 2022-04-23

887 Self-consistent solution to the Flory-Huggins model and applications in protein liquid-liquid phase separation

Qian, D.; Michaels, T. C. T.; Knowles, T. P. J.

10.1101/2022.04.23.489256 — biophysics — Posted on 2022-04-23

888 GeneVector: Identification of transcriptional programs using dense vector representations defined by mutual information.

Ceglia, N.; Sethna, Z.; Uhlitz, F.; Bojilova, V.; Rusk, N.; Burman, B.; Chow, A.; Salehi, S.; Kabeer, F.; Aparicio, S. H.; Greenbaum, B. D.; Shah, S. P.; McPherson, A.

10.1101/2022.04.22.487554 — bioinformatics — Posted on 2022-04-23

889 Comprehensive phylogenetic analysis of the ribonucleotide reductase family reveals an ancestral clade and the role of insertions and extensions in diversification

Burnim, A. A.; Spence, M. A.; Xu, D.; Jackson, C.; Ando, N.

10.1101/2022.04.23.489257 — bioinformatics — Posted on 2022-04-23

890 A revisit to universal single-copy genes in bacterial genomes

Wang, S.; Ventolero, M.; Hu, H.; Li, x.

10.1101/2022.04.23.489213 — bioinformatics — Posted on 2022-04-23

891 A method to enrich polypeptidyl-tRNAs to capture snapshots of translation in the cell

Yamakawa, A.; Niwa, T.; Chadani, Y.; Taguchi, H.

10.1101/2022.04.22.489242 — biochemistry — Posted on 2022-04-23

892 Characterization of Reactive Oxygen Species Signaling changes in a cell culture model of skeletal muscle ageing, and its application to screening pharmacokinetically-relevant exposures of dietary polyphenols for bioactivity.

Hayes, N.; Fogarty, M.; Sadofsky, L.; Jones, H. S.

10.1101/2021.11.20.469396 — pharmacology and toxicology — Posted on 2022-04-23

893 Divergent acute versus prolonged in vivo GLP-1R responses in β-arrestin 2-deleted primary beta cells

Bitsi, S.; Manchanda, Y.; ElEid, L.; Mohamed, N.; Hansen, B.; Suba, K.; Rutter, G. A.; Salem, V.; Jones, B.; Tomas, A.

10.1101/2022.04.21.489075 — cell biology — Posted on 2022-04-23

894 A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence

Kang, T.; Moore, E. C.; Kopania, E.; King, C.; Schilling, B.; Campisi, J.; Good, J.; Brem, R.

10.1101/2022.04.21.489100 — genomics — Posted on 2022-04-23

895 Isotopic reconstruction of the subsistence strategy for a Central Italian Bronze Age community (Pastena cave, 2nd millennium BCE).

Cortese, F.; de angelis, f.; achino, k. f.; bontempo, l.; Di Cicco, M. R.; gatta, m.; Lubritto, C.; Salari, L.; silvestri, l.; Rickards, O.; Rolfo, M. F.

10.1101/2022.04.21.488758 — evolutionary biology — Posted on 2022-04-23

896 Drug design and repurposing with a sequence-to-drug paradigm

Chen, L.; Fan, Z.; Chang, J.; Yang, R.; Guo, H.; Zhang, Y.; Yang, T.; Zhou, C.; Chen, Z.; Zheng, C.; Hao, X.; Zhang, K.; Cui, R.; Ding, Y.; Zhang, N.; Luo, X.; Jiang, H.; Zhang, S.; Zheng, M.

10.1101/2022.03.26.485909 — molecular biology — Posted on 2022-04-23

897 Characterization of human immunodeficiency virus (HIV-1) envelope glycoprotein variants selected for resistance to a CD4-mimetic compound

Anang, S.; Richard, J.; Bourassa, C.; Goyette, G.; Chiu, T.-J.; Chen, H.-C.; Smith, A. B.; Madani, N.; Finzi, A.; Sodroski, J. G.

10.1101/2022.04.21.489129 — microbiology — Posted on 2022-04-23

898 Thalamo-hippocampal pathway regulates incidental memory load: insights from sex differences

Torromino, G.; Loffredo, V.; Cavezza, D.; Sonsini, G.; Esposito, F.; Crevenna, A. H.; Gioffré, M.; De Risi, M.; Treves, A.; Griguoli, M.; De Leonibus, E.

10.1101/2021.08.07.453742 — neuroscience — Posted on 2022-04-23

899 Pervasive conditional selection of driver mutations and modular epistasis networks in cancer

Iranzo, J.; Gruenhagen, G.; Calle-Espinosa, J.; Koonin, E. V.

10.1101/2022.01.10.475617 — cancer biology — Posted on 2022-04-23

900 Multi-omic analyses reveal a role for mammalian CIC in cell cycle regulation and mitotic fidelity

Takemon, Y.; LeBlanc, V. G.; Song, J.; Chan, S. Y.; Lee, S. D.; Trinh, D. L.; Ahmad, S. T.; Brothers, W. R.; Corbett, R. D.; Gagliardi, A.; Moradian, A.; Cairncross, J. G.; Yip, S.; Aparicio, S. A.; Chan, J. A.; Hughes, C. S.; Morin, G. B.; Gorski, S. M.; Chittaranjan, S.; Marra, M. A.

10.1101/533323 — cancer biology — Posted on 2022-04-23

901 distinct: a novel approach to differential distribution analyses

Tiberi, S.; Crowell, H. L.; Samartsidis, P.; Weber, L. M.; Robinson, M. D.

10.1101/2020.11.24.394213 — bioinformatics — Posted on 2022-04-23

902 A guide to trajectory inference and RNA velocity

Weiler, P.; Van den Berge, K.; Street, K.; Tiberi, S.

10.1101/2021.12.22.473434 — bioinformatics — Posted on 2022-04-23

903 Artificial Intelligence uncovers carcinogenic human metabolites

Mittal, A.; Mohanty, S. K.; Gautam, V.; Arora, S.; Saproo, S.; Gupta, R.; S, R.; Garg, P.; Aggarwal, A.; R, P.; Dixit, N. K.; Singh, V. P.; Mehta, A.; Tayal, J.; Naidu, S.; Sengupta, D.; Ahuja, G.

10.1101/2021.11.20.469412 — bioinformatics — Posted on 2022-04-23

904 Multi-omics Analyses Provide Insight into the Biosynthesis Pathways of Fucoxanthin in Isochrysis galbana

Chen, D.; Yuan, X.; Zheng, X.; Fang, J.; Lin, G.; Li, R.; Chen, J.; He, W.; Huang, Z.; Fan, W.; Liang, L.; Lin, C.; Zhu, J.; Chen, Y.; Xue, T.

10.1101/2021.11.28.470214 — bioinformatics — Posted on 2022-04-23

905 Guidance by followers ensures long-range coordination of cell migration through α-Catenin mechanoperception

Boutillon, A.; Escot, S.; Elouin, A.; Jahn, D.; Gonzalez-Tirado, S.; Starruss, J.; Brusch, L.; David, N. B.

10.1101/2021.04.26.441407 — developmental biology — Posted on 2022-04-23

906 Metabolic size scaling reflects growth performance effects on age-size relationships in mussels (Mytilus galloprovincialis).

Ibarrola, I.; Arranz, K.; Markaide, P.; Navarro, E.

10.1101/2022.04.22.489162 — physiology — Posted on 2022-04-22

907 Implications for food safety of the size and location of fragments of lead shotgun pellets embedded in hunted carcasses of small game animals intended for human consumption

Green, R.; Taggart, M.; Pain, D.; Smithson, K.

10.1101/2022.04.22.489221 — pharmacology and toxicology — Posted on 2022-04-22

908 Locomotion control during curb descent: Bilateral ground reaction variables covary consistently during the double support phase regardless of future foot placement constraints

Cui, C.; Kulkarni, A.; Rietdyk, S.; Ambike, S.

10.1101/2022.04.22.489222 — bioengineering — Posted on 2022-04-22

909 Dual RNA-seq reveals a type 6 secretion system-dependent blockage of TNF-α signaling and BicA as a Burkholderia pseudomallei virulence factor important during gastrointestinal infection

Sanchez-Villamil, J. I.; Tapia, D.; Khakhum, N.; Widen, S. G.; Torres, A. G.

10.1101/2022.04.22.489234 — microbiology — Posted on 2022-04-22

910 Neural connectivity molecules best identify the heterogeneous clock and dopaminergic cell types in the Drosophila adult brain

Ma, D.; Herndon, N.; Le, J. Q.; Abruzzi, K.; Rosbash, M.

10.1101/2022.04.22.489196 — neuroscience — Posted on 2022-04-22

911 Individual prediction tendencies facilitate cortical speech tracking

Schubert, J.; Schmidt, F.; Gehmacher, Q.; Bresgen, A.; Weisz, N.

10.1101/2022.04.22.489224 — neuroscience — Posted on 2022-04-22

912 Cocaine regulation of Nr4a1 chromatin bivalency and mRNA in male and female mice.

Fischer, D. K.; Krick, K. S.; Han, C.; Woolf, M. T.; Heller, E. A.

10.1101/2022.04.22.489203 — neuroscience — Posted on 2022-04-22

913 Ventral Hippocampal Infusions of C20:0 Ceramide Stimulate Microglia and Induce Anhedonia-like Behavior in Female and Male Rats

Sambolin, L.; Feliciano, A.; Tirado, L.; Suarez, C.; Pacheco, D.; Fonseca, W.; Hernandez, A.; Colon, M.; Porter, J. T.

10.1101/2022.04.22.489192 — neuroscience — Posted on 2022-04-22

914 The effect of sleep continuity disruption on multimodal emotion processing and regulation: a laboratory-based, randomized, controlled experiment in good sleepers

Reid, M.; Omlin, X.; Espie, C.; Sharman, R.; Tamm, S.; Kyle, S.

10.1101/2022.04.22.489209 — neuroscience — Posted on 2022-04-22

915 Polarly localized WPR proteins interact with PAN receptors and the actin cytoskeleton during maize stomatal development

Nan, Q.; Char, S. N.; Yang, B.; Facette, M. R.

10.1101/2022.04.22.489215 — plant biology — Posted on 2022-04-22

916 Engineered extracellular matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids

LeSavage, B. L.; Gilchrist, A. E.; Krajina, B. A.; Karlsson, K.; Smith, A. R.; Karagyozova, K.; Klett, K. C.; Curtis, C.; Kuo, C. J.; Heilshorn, S. C.

10.1101/2022.04.22.488943 — cancer biology — Posted on 2022-04-22

917 cMYC protein interactions and chromatin association in NUT carcinoma

Zee, B. M.; Alekseyenko, A. A.; Smolko, A. E.; Kuroda, M. I.

10.1101/2022.04.22.489219 — cancer biology — Posted on 2022-04-22

918 Multiple modes of substrate hydrolysis-induced covalent modification of strigolactone receptors

Chen, J.; Shukla, D.

10.1101/2022.04.22.489200 — biophysics — Posted on 2022-04-22

919 Prediction of Kinase-Substrate Associations Using The Functional Landscape of Kinases and Phosphorylation Sites

Ayati, M.; Yilmaz, S.; Blasco Tavares Pereira Lopes, F.; Chance, M. R.; Koyuturk, M.

10.1101/2022.04.22.489231 — bioinformatics — Posted on 2022-04-22

920 Extracting multiple surfaces from 3D microscopy images in complex biological tissues with the Zellige software tool.

Trebeau, C.; Boutet de Monvel, J.; Altay, G.; Tinevez, J.-Y.; Etournay, R.

10.1101/2022.04.05.485876 — bioinformatics — Posted on 2022-04-22

921 METAbolomics data Balancing with Over-sampling Algorithms (META-BOA): an online resource for addressing class imbalance

Hashimoto-Roth, E.; Surendra, A.; Lavallee-Adam, M.; Bennett, S. A. L.; Cuperlovic-Culf, M.

10.1101/2022.04.21.489108 — bioinformatics — Posted on 2022-04-22

922 Detection and discrimination of single nucleotide polymorphisms by quantification of CRISPR-Cas catalytic efficiency

Blanluet, C.; Huyke, D. A.; Ramachandran, A.; Avaro, A. S.; Santiago, J. G.

10.1101/2022.04.22.489229 — bioengineering — Posted on 2022-04-22

923 Simple within-stride changes in treadmill speed can drive selective changes in human gait symmetry

Browne, M. G.; Stenum, J.; Padmanabhan, P.; Roemmich, R. T.

10.1101/2022.04.22.489204 — bioengineering — Posted on 2022-04-22

924 Peroxisomal ATPase ATAD1 acts in quality control of the protein import machinery

Ott, J.; Sehr, J.; Lindemann, C.; Barkovits, K.; Bader, V.; Winklhofer, K.; Marcus, K.; Schliebs, W.; Erdmann, R.

10.1101/2022.04.22.489171 — biochemistry — Posted on 2022-04-22

925 Directed evolution of angiotensin-converting enzyme 2 (ACE2) peptidase activity profiles for therapeutic applications

Heinzelman, P.; Romero, P. A.

10.1101/2022.01.03.474817 — biochemistry — Posted on 2022-04-22

926 A phased chromosome-level genome and full mitochondrial sequence for the dikaryotic myrtle rust pathogen, Austropuccinia psidii

Edwards, R. J.; Dong, C.; Park, R. F.; Tobias, P. A.

10.1101/2022.04.22.489119 — genomics — Posted on 2022-04-22

927 The molecular consequences of androgen activity in the human breast

Raths, F.; Karimzadeh, M.; Ing, N.; Martinez, A.; Qu, Y.; Lee, T.-Y.; Mulligan, B.; Devkota, S.; Wang, B.; Giuliano, A. E.; Bose, S.; Goodarzi, H.; Ray, E. C.; Cui, X.; Knott, S. R. V.

10.1101/2022.04.22.489095 — genomics — Posted on 2022-04-22

928 Genetic dissection of the pluripotent proteome through multi-omics data integration

Aydin, S.; Pham, D. T.; Zhang, T.; Keele, G. R.; Skelly, D. A.; Pankratz, M.; Choi, T.; Gygi, S.; Reinholdt, L. G.; Baker, C. L.; Churchill, G. A.; Munger, S. C.

10.1101/2022.04.22.489216 — genetics — Posted on 2022-04-22

929 Testing for genetic assimilation with phylogenetic comparative analysis: Conceptual, methodological, and statistical considerations

Gunderson, A. R.; Revell, L. J.

10.1101/2021.12.28.473512 — evolutionary biology — Posted on 2022-04-22

930 Quantifying the fraction of new mutations that are recessive lethal

Wade, E. E.; Kyriazis, C.; Cavassim, M. I. A.; Lohmueller, K. E.

10.1101/2022.04.22.489225 — evolutionary biology — Posted on 2022-04-22

931 Divergent acute versus prolonged in vivo GLP-1R responses in β-arrestin 2-deleted primary beta cells

Bitsi, S.; Manchanda, Y.; ElEid, L.; Mohamed, N.; Hansen, B.; Suba, K.; Rutter, G. A.; Salem, V.; Jones, B.; Tomas, A.

10.1101/2022.04.21.489075 — cell biology — Posted on 2022-04-22

932 Adenine base editing is an efficient approach to restore function in FA patient cells without double-stranded DNA breaks

Siegner, S. M.; Clemens, A.; Ugalde, L.; Garcia-Garcia, L.; Bueren, J. A.; Rio, P.; Karasu, M. E.; Corn, J. E.

10.1101/2022.04.22.489197 — molecular biology — Posted on 2022-04-22

933 Circular mRNA encoded PROTAC (RiboPROTAC) as a new platform for the degradation of intracellular therapeutic targets

Yang, J.; Sun, J.; Zhu, J.; Du, Y.; Tan, Y.; Wei, L.; Zhao, Y.; Hou, Q.; Zhang, Y.; Sun, Z.; Zuo, C.

10.1101/2022.04.22.489232 — molecular biology — Posted on 2022-04-22

934 Targeted single-cell genomics reveals novel host adaptation strategies of the symbiotic bacteria Endozoicomonas in Acropora tenuis coral

Ide, K.; Nishikawa, Y.; Maruyama, T.; Tsukada, Y.; Kogawa, M.; Takeda, H.; Wagatsuma, R.; Miyaoka, R.; Nakano, Y.; Kinjo, K.; Ito, M.; Hosokawa, M.; Yura, K.; Suda, S.; Takeyama, H.

10.1101/2022.04.22.489146 — microbiology — Posted on 2022-04-22

935 Run-on sequencing reveals nascent transcriptomics of the human microbiome

Vill, A. C.; Danko, C. G.; Rice, E. J.; De Vlaminck, I.; Brito, I. L.

10.1101/2022.04.22.489220 — microbiology — Posted on 2022-04-22

936 The WalRK Two-component system is Essential for Proper Cell Envelope Biogenesis in Clostridioides difficile

Muh, U.; Ellermeier, C. D.; Weiss, D. S.

10.1101/2022.04.01.486798 — microbiology — Posted on 2022-04-22

937 IL-17A controls CNS autoimmunity by regulating gut microbiota and inducing regulatory T cells

Shahi, S. K.; Ghimire, S.; Jensen, S. N.; Lehman, P.; Borcherding, N.; Gibson-Corley, K.; Ganesan, S. M.; Karandikar, N. J.; Mangalam, A. K.

10.1101/2022.04.22.489206 — immunology — Posted on 2022-04-22

938 Fecal microbiota transplantation derived from Alzheimer's disease mice worsens brain trauma outcomes in wild-type controls

Soriano, S.; Curry, K.; Wang, Q.; Chow, E.; Treangen, T.; Villapol, S.

10.1101/2021.11.23.469725 — neuroscience — Posted on 2022-04-22

939 Impacts of dams on freshwater turtles: a global review to identify conservation solutions

Barcenas-Garcia, A.; Michalski, F.; Morgan, W. H.; Smith, R. K.; Sutherland, W. J.; Gibbs, J. P.; Norris, D.

10.1101/2021.10.21.465338 — zoology — Posted on 2022-04-22

940 Identifying the best approximating model in Bayesian phylogenetics: Bayes factors, cross-validation or wAIC?

Lartillot, N.

10.1101/2022.04.22.489153 — bioinformatics — Posted on 2022-04-22

941 SMURF: embedding single-cell RNA-seq data with matrix factorization preserving selfconsistency

Wang, B.; Pu, J.; Chen, L.; Li, S.

10.1101/2022.04.22.489140 — bioinformatics — Posted on 2022-04-22

942 Evolutionary conservation and divergence of the transcriptional regulation of bivalve shell secretion across life history stages

Cavallo, A.; Clark, M. S.; Peck, L. S.; Harper, E. M.; Sleight, V. A.

10.1101/2022.04.22.489168 — evolutionary biology — Posted on 2022-04-22

943 MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle

Fitzgerald, G.; Turiel, G.; Gorski, T.; Soro-Arnaiz, I.; Zhang, J.; Casartelli, N. C.; Masschelein, E.; Maffiuletti, N. A.; Sutter, R.; Leunig, M.; Farup, J.; De Bock, K.

10.1101/2022.04.22.489158 — cell biology — Posted on 2022-04-22

944 Protein preference and elevated plasma FGF21 induced by dietary protein restriction is similar in both male and female mice

Volcko, K. L.; McCutcheon, J. E.

10.1101/2022.04.22.489137 — neuroscience — Posted on 2022-04-22

945 Synapses learn to utilize pre-synaptic noise for the prediction of postsynaptic dynamics

Kappel, D.; Tetzlaff, C.

10.1101/2022.04.22.489175 — neuroscience — Posted on 2022-04-22

946 Single-cell mosaicism analysis reveals cell-type-specific somatic mutational burden in Alzheimer's Dementia

Kousi, M.; Boix, C. A.; Park, Y. P.; Mathys, H.; Sledzieski, S.; Peng, Z.; Bennett, D. A.; Tsai, L.-H.; Kellis, M.

10.1101/2022.04.21.489103 — neuroscience — Posted on 2022-04-22

947 The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

Noyes, C.; Kitajima, S.; Li, F.; Suita, Y.; Miriyala, S.; Isaac, S.; Ahsan, N.; Knelson, E.; Vajdi Hoojghan, A.; Tani, T.; Thai, T.; Xu, D.; Murai, J.; Tapinos, N.; Takahashi, C.; Barbie, D.; Yajima, M.

10.1101/2022.04.22.489111 — cancer biology — Posted on 2022-04-22

948 High-Throughput Global Phosphoproteomic Profiling Using Phospho Heavy-Labeled-Spiketide FAIMS Stepped-CV DDA (pHASED)

Staudt, D. E.; Murray, H. C.; Skerrett-Byrne, D. A.; Smith, N. D.; Jamaluddin, M. F.; Kahl, R. G. S.; Duchatel, R. J.; Germon, Z.; McLachlan, T.; Jackson, E. R.; Findlay, I. J.; Kearney, P. S.; Mannan, A.; McEwen, H. P.; Douglas, A. M.; Nixon, B.; Verrills, N. M.; Dun, M. D.

10.1101/2022.04.22.489124 — biochemistry — Posted on 2022-04-22

949 SARS-CoV-2 spike variants differ in their allosteric response to linoleic acid

Oliveira, A. S. F.; Shoemark, D. F.; Davidson, A. D.; Berger, I.; Schaffitzel, C.; Mulholland, A. J.

10.1101/2022.04.21.489022 — biochemistry — Posted on 2022-04-22

950 The Free Fatty Acid-Binding Pocket is a Conserved Hallmark in Pathogenic β-Coronavirus Spike Proteins from SARS-CoV to Omicron

Toelzer, C.; Gupta, K.; Yadav, S. K. N.; Hodgson, L.; Kavanagh Williamson, M.; Buzas, D.; Borucu, U.; Powers, K.; Stenner, R.; Vasileiou, K.; Garzoni, F.; Fitzgerald, D.; Payre, C.; Lambeau, G.; Davidson, A. D.; Verkade, P.; Frank, M.; Berger, I.; Schaffitzel, C.

10.1101/2022.04.22.489083 — biochemistry — Posted on 2022-04-22

951 Crop management shapes the diversity and activity of DNA and RNA viruses in the rhizosphere

Muscatt, G.; Hilton, S.; Raguideau, S.; Teakle, G.; Lidbury, I. D. E. A.; Wellington, E. M. H.; Quince, C.; Millard, A.; Bending, G. D.; Jameson, E.

10.1101/2022.04.22.488307 — ecology — Posted on 2022-04-22

952 Integrated optical device for Structured Illumination Microscopy

Calvarese, M.; Paie, P.; Candeo, A.; Calisesi, G.; Ceccarelli, F.; Valentini, G.; Osellame, R.; Gong, H.; Neil, M. A.; Bragheri, F.; Bassi, A.

10.1101/2022.04.22.489094 — cell biology — Posted on 2022-04-22

953 Intrinsic furin-mediated cleavability of the spike S1/S2 site from SARS-CoV-2 variant B.1.529 (Omicron)

Lubinski, B.; Jaimes, J. A.; Whittaker, G.

10.1101/2022.04.20.488969 — microbiology — Posted on 2022-04-22

954 A highly sensitive strand-specific multiplex RT-qPCR assay for quantitation of Zika virus replication

Barnard, T. R.; Wang, A. B.; Sagan, S. M.

10.1101/2022.04.22.489195 — microbiology — Posted on 2022-04-22

955 An Efficient Approach for SARS-CoV-2 Monoclonal Antibody Production via Modified mRNA-LNP Immunization

Hsu, F.-F.; Liang, K.-H.; Kumari, M.; Chen, W. Y.; Lin, H. T.; Cheng, C. M.; Tao, M.-H.; Wu, H.-C.

10.1101/2022.04.20.488878 — immunology — Posted on 2022-04-22

956 Impaired immune response drives age-dependent severity of COVID-19

Beer, J.; Crotta, S.; Breithaupt, A.; Ohnemus, A.; Becker, J.; Sachs, B.; Kern, L.; Llorian, M.; Ebert, N.; Labroussaa, F.; Tran, T. T. N.; Trueeb, B. S.; Jores, J.; Thiel, V.; Beer, M.; Fuchs, J.; Kochs, G.; Wack, A.; Schwemmle, M.; Schnepf, D.

10.1101/2022.04.21.489072 — immunology — Posted on 2022-04-22

957 Organization of the corticotropin-releasing hormone and corticotropin-releasing hormone-binding protein systems in the central nervous system of the sea lamprey Petromyzon marinus

Sobrido-Camean, D.; Gonzalez-Llera, L.; Anadon, R.; Barreiro-Iglesias, A.

10.1101/2022.04.22.489136 — neuroscience — Posted on 2022-04-22

958 Chemogenetic disconnection between the orbitofrontal cortex and the rostromedial caudate nucleus disrupts motivational control of goal-directed action

Oyama, K.; Hori, Y.; Mimura, K.; Nagai, Y.; Eldridge, M. A.; Saunders, R. C.; Miyakawa, N.; Hirabahashi, T.; Hori, Y.; Inoue, K.-i.; Suhara, T.; Takada, M.; Higuchi, M.; Richmond, B. J.; Minamimoto, T.

10.1101/2022.04.22.489147 — neuroscience — Posted on 2022-04-22

959 Metabolic modelling of the human gut microbiome in type 2 diabetes patients in response to metformin treatment

Ezzamouri, B.; Rosario, D.; Bidkhori, G.; Lee, S.; Uhlen, M.; Shoaie, S.

10.1101/2022.04.22.489154 — systems biology — Posted on 2022-04-22

960 A revised phylogenetic classification for Viola (Violaceae)

Marcussen, T.; Ballard, H. E.; Danihelka, J.; Flores, A. R.; Nicola, M. V.; Watson, J. M.

10.1101/2022.04.22.489152 — plant biology — Posted on 2022-04-22

961 Genomic and transcriptomic landscape of advanced renal cell cancer to individualize treatment strategy

de Joode, K.; van de Geer, W. S.; van Leenders, G. J. L. H.; Hamberg, P.; Westgeest, H. M.; Beeker, A.; Oosting, S. F.; van Rooijen, J. M.; Beerepoot, L. V.; Labots, M.; Mathijssen, R. H. J.; Lolkema, M. P.; Cuppen, E.; Sleijfer, S.; van de Werken, H. J. G.; van der Veldt, A. A. M.

10.1101/2022.04.22.488773 — cancer biology — Posted on 2022-04-22

962 ACSS2 Regulates HIF-2α Degradation through the E3-Ubiquitin Ligase MUL1 in Clear Cell Renal Cell Carcinoma

Bacigalupa, Z. A.; Brown, W. A.; Krystofiak, E. S.; Wolf, M. M.; Hongo, R. A.; Landis, M.; Amason, E. K.; Beckermann, K. E.; Rathmell, J.; Rathmell, W. K.

10.1101/2022.04.21.489116 — cancer biology — Posted on 2022-04-22

963 Membrane tension spatially organizes lysosomal exocytosis

Lachuer, H.; Le, L.; Leveque-fort, S.; Goud, B.; Schauer, K.

10.1101/2022.04.22.489160 — biophysics — Posted on 2022-04-22

964 Active mechanics of sea star oocytes

Foster, P. J.; Fürthauer, S.; Fakhri, N.

10.1101/2022.04.22.489189 — biophysics — Posted on 2022-04-22

965 Archaeal bundling pili of Pyrobaculum calidifontis reveal similarities between archaeal and bacterial biofilms

Wang, F.; Cvirkaite-Krupovic, V.; Krupovic, M.; Egelman, E.

10.1101/2022.04.22.489182 — biophysics — Posted on 2022-04-22

966 CONCERT: Genome-wide prediction of sequence elements that modulate DNA replication timing

Yang, Y.; Wang, Y.; Zhang, Y.; Ma, J.

10.1101/2022.04.21.488684 — bioinformatics — Posted on 2022-04-22

967 Metatranscriptomic comparison of viromes in endemic and introduced passerines in New Zealand

French, R. K.; Filion, A.; Niebuhr, C. N.; Holmes, E. C.

10.1101/2022.04.21.489127 — bioinformatics — Posted on 2022-04-22

968 The contribution of mate-choice, couple convergence and confounding to assortative mating

Sjaarda, J.; Kutalik, Z.

10.1101/2022.04.22.489170 — genetics — Posted on 2022-04-22

969 Pharmacological intervention of the FGF-PTH axis as a potential therapeutic for ciliopathies

Bonatto-Paese, C. L.; Chang, C.-F.; Kristekova, D.; Brugmann, S.

10.1101/2022.04.21.489105 — developmental biology — Posted on 2022-04-22

970 Nodal signaling establishes a competency window for stochastic cell fate switching

Economou, A. D.; Guglielmi, L.; East, P.; Hill, C. S.

10.1101/2022.04.22.489156 — developmental biology — Posted on 2022-04-22

971 Spt4 drives cellular senescence by activating non-coding RNA transcription in ribosomal RNA gene clusters

Yokoyama, M.; Sasaki, M.; Kobayashi, T.

10.1101/2022.04.22.488906 — molecular biology — Posted on 2022-04-22

972 Exceptional yield vesicle packaged recombinant protein production from E. coli.

Eastwood, T. A.; Baker, K.; Streather, B. R.; Allen, N.; Wang, L.; Botchway, S. W.; Brown, I. R.; Hiscock, J. R.; Lennon, C.; Mulvihill, D. P.

10.1101/2022.04.22.489142 — molecular biology — Posted on 2022-04-22

973 Phenotypic characterization and analysis of complete genomes of two distinct strains of the proposed species "L. swaminathanii"

Hudson, L. K.; Chaggar, H. K.; Schamp, C. N.; Claxton, M. L.; Bryan, D. W.; Peters, T. L.; Song, Y.; Carlin, C. R.; den Bakker, H. C.; Denes, T. G.

10.1101/2022.04.22.489179 — microbiology — Posted on 2022-04-22

974 Enhanced Mirror Neuron Network Activity and Effective Connectivity during Live Interaction

Hsu, C.-T.; Sato, W.; Kochiyama, T.; Nakai, R.; Asano, K.; Abe, N.; Yoshikawa, S.

10.1101/2022.04.22.489113 — neuroscience — Posted on 2022-04-22

975 Circulating U13 small nucleolar RNA as a candidate biomarker for Huntington's disease

Romano, C.; Romano, S.; Peconi, M.; Fiore, A.; Bellucci, G.; Morena, E.; Troili, F.; Cipollini, V.; Annibali, V.; Giglio, S.; Mechelli, R.; Ferraldeschi, M.; Veneziano, L.; Mantuano, E.; Sani, G.; Vecchione, A.; Umeton, R.; Giubilei, F.; Salvetti, M.; Corbo, R.; Scarabino, D.; Ristori, G.

10.1101/2022.04.22.489178 — neuroscience — Posted on 2022-04-22

976 Targeting diverse operational regimes in recurrent spiking networks

Ekelmans, P.; Kraynyukova, N.; Tchumatchenko, T.

10.1101/2022.04.22.489005 — neuroscience — Posted on 2022-04-22

977 Multisite imaging of neural activity using a genetically encoded calcium sensor in the honey bee Apis mellifera

Carcaud, J.; Otte, M.; Gruenewald, B.; Haase, A.; Sandoz, J.-C.; Beye, M.

10.1101/2022.04.22.489138 — neuroscience — Posted on 2022-04-22

978 CASK and FARP coordinately control pre- and post-synaptic function

Hu, Z.; Li, L.; Liu, H.; Qian, K.-Y.; Nurrish, S.; Zeng, X.-T.; Kaplan, J. M.; Tong, X.-J.; Hu, Z.

10.1101/2022.04.22.489135 — neuroscience — Posted on 2022-04-22

979 A Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Dysregulation of the Neurovascular Unit Relevant to Brain Inflammation

Chiang, W.; Litzburg, A.; Yanchik-Slade, F.; Li, H.; Nilsson, B. L.; Gelbard, H. A.; Krauss, T. D.

10.1101/2022.04.20.488933 — neuroscience — Posted on 2022-04-22

980 Improved antiproliferative activity of doxorubicin-loaded calcium phosphate nanoparticles against melanoma cells

Lima, I. B.; Alvarenga, B. M.; Totaro, P. I. S. d.; Boratto, F.; Leite, E. A.; Guimaraes, P. P. G.

10.1101/2022.04.21.489118 — cancer biology — Posted on 2022-04-22

981 Designing multiphase biomolecular condensates by coevolution of protein mixtures

Chew, P. Y.; Joseph, J. A.; Collepardo-Guevara, R.; Reinhardt, A.

10.1101/2022.04.22.489187 — biophysics — Posted on 2022-04-22

982 Crosslinker design determines microtubule network organization by opposing motors

Henkin, G.; Chew, W.-X.; Nedelec, F.; Surrey, T.

10.1101/2022.04.22.488007 — biophysics — Posted on 2022-04-22

983 Biomolecular condensates can both accelerate and suppress aggregation of α-synuclein

Lipinski, W. P.; Visser, B. S.; Robu, I.; Abolghassemi Fakhree, M. A.; Lindhoud, S.; Claessens, M. M. A. E.; Spruijt, E.

10.1101/2022.04.22.489149 — biophysics — Posted on 2022-04-22

984 Statistical analysis of spatially resolved transcriptomic data by incorporating multi-omics auxiliary information

Li, Y.; Zhou, X.; Cao, H.

10.1101/2022.04.22.489194 — bioinformatics — Posted on 2022-04-22

985 Hi-LASSO: High-performance Python and Apache spark packages for feature selection with high-dimensional data

Jo, J.; Jung, S.; Park, J.; Kim, Y.; Kang, M.

10.1101/2022.04.22.489133 — bioinformatics — Posted on 2022-04-22

986 METAbolomics data Balancing with Over-sampling Al-gorithms (META-BOA): an online resource for addressing class imbalance

Hashimoto-Roth, E.; Surendra, A.; Lavallee-Adam, M.; Bennett, S. A. L.; Cuperlovic-Culf, M.

10.1101/2022.04.21.489108 — bioinformatics — Posted on 2022-04-22

987 scTagger: Fast and accurate matching of cellular barcodes across short- and long-reads of single-cell RNA-seq experiments

Ebrahimi, G.; Orabi, B.; Robinson, M.; Chauve, C.; Flannigan, R.; Hach, F.

10.1101/2022.04.21.489097 — bioinformatics — Posted on 2022-04-22

988 How does data structure impact cell-cell similarity? Evaluating the influence of structural properties on proximity metric performance in single cell RNA-seq data

Watson, E. R.; Mora, A.; Taherian Fard, A.; Mar, J. C.

10.1101/2022.04.21.489121 — bioinformatics — Posted on 2022-04-22

989 De novo phytosterol synthesis in animals

Michellod, D.; Bien, T.; Birgel, D.; Jensen, M.; Kleiner, M.; Fearn, S.; Zeidler, C.; Gruber-Vodicka, H. R.; Dubilier, N.; Liebeke, M.

10.1101/2022.04.22.489198 — biochemistry — Posted on 2022-04-22

990 An intrinsic oscillator underlies visual navigation in ants.

CLEMENT, L.; Schwarz, S.; Wystrach, A.

10.1101/2022.04.22.489150 — animal behavior and cognition — Posted on 2022-04-22

991 A transcriptional program shared across lineages underlies cell differentiation during metazoan development

Ruiz-Romero, M.; Klein, C. C.; Perez-Lluch, S.; Abad, A.; Breschi, A.; Guigo, R.

10.1101/2022.04.22.489139 — genomics — Posted on 2022-04-22

992 Secondary reversion to sexual monomorphism associated with tissue-specific loss of doublesex expression

Gao, J.-j.; Barmina, O.; Thompson, A.; Kim, B. Y.; Suvorov, A.; Tanaka, K.; Watabe, H.; Toda, M. J.; Chen, J.-M.; Katoh, T. K.; Kopp, A.

10.1101/2022.04.21.489080 — evolutionary biology — Posted on 2022-04-22

993 A revised perspective on the evolution of troponin I and troponin T in vertebrates

Joyce, W.; Ripley, D. M.; Gillis, T. E.; Black, A. C.; Shiels, H. A.; Hoffmann, F.

10.1101/2022.04.22.489046 — evolutionary biology — Posted on 2022-04-22

994 Evolutionary history of metazoan TMEM16 family

Yuan, X.; Zhu, Y.; Kadowaki, T.

10.1101/2022.04.22.489151 — evolutionary biology — Posted on 2022-04-22

995 Will The Grass Be Greener On The Other Side Of Climate Change?

Morris, C.; Kirkman, K.; Zacharias, P.

10.1101/2022.04.22.489016 — ecology — Posted on 2022-04-22

996 Interspecific allometric scaling in eDNA production in fishes reflects physiological and surface area allometry

Yates, M. C.; Wilcox, T.; Stoeckle, M.; Heath, D.

10.1101/2022.04.22.489177 — ecology — Posted on 2022-04-22

997 Inactivation of histone chaperone HIRA unmasks a link between normal embryonic development of melanoblasts and maintenance of adult melanocyte stem cells

Jaber-Hijazi, F.; Swaminathan, K.; Gilroy, K.; Wenzel, A. T.; Lagnado, A.; Kirschner, K.; Robertson, N. A.; Reid, C.; Fullarton, N.; Pawlikowski, J.; Blyth, K.; Mesirov, J. P.; Rai, T. S.; Passos, J. F.; Machesky, L. M.; Adams, P. D.

10.1101/2022.04.22.489166 — developmental biology — Posted on 2022-04-22

998 Paracrine factors of stressed peripheral blood mononuclear cells activate pro-angiogenic and anti- proteolytic processes in whole blood cells and protect the endothelial barrier

Copic, D.; Direder, M.; Schossleitner, K.; Laggner, M.; Klas, K.; Bormann, D.; Ankersmit, H. J.; Mildner, M.

10.1101/2022.04.22.489132 — cell biology — Posted on 2022-04-22

999 The ciliopathy protein CCDC66 controls mitotic progression and cytokinesis by promoting microtubule nucleation and organization

Batman, U.; Deretic, J.; Firat-Karalar, E. N.

10.1101/2022.04.22.489036 — cell biology — Posted on 2022-04-22

1000 Machine-Learning-Based Olfactometry: Odor Descriptor Clustering Analysis for Olfactory Perception Prediction of Odorant Molecules

Shang, L.; Tang, F.; Liu, C.; Chen, B.; Liu, L.; Hayashi, K.

10.1101/2022.04.20.488973 — molecular biology — Posted on 2022-04-22

1001 Structure-based discovery and in vitro validation of selective inhibitors of Chloride Intracellular Channel 4 protein.

Olotu, F.; Medina-Carmona, E.; El-Hamdaoui, A.; Tastan Bishop, O.; Ortega-Roldan, J. L.; Abdul-Salam, V. B.

10.1101/2022.04.21.489122 — molecular biology — Posted on 2022-04-22

1002 Formation of multiple flagella caused by a mutation of the flagellar rotor protein FliM in Vibrio alginolyticus

Homma, M.; Takekawa, N.; Fujiwara, K.; Hao, Y.; Onoue, Y.; Kojima, S.

10.1101/2022.04.21.489128 — microbiology — Posted on 2022-04-22

1003 Oral rabies vaccination of dogs - experiences from a field trial in Namibia

Freuling, C. M.; Busch, F.; Vos, A.; Ortmann, S.; Lohr, F.; Hedimbi, N.; Peter, J.; Nelson, H. A.; Shoombe, K.; Shilongo, A.; Gorejena, B.; Kaholongo, L.; Khaiseb, S.; van der Westhuizen, J.; Dietze, K.; Guertse, G.; Mueller, T.

10.1101/2022.04.21.488865 — microbiology — Posted on 2022-04-22

1004 HIV-linked gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV

Zhang, Y.; Andreu-Sanchez, S.; Vadaq, N.; Wang, D.; Matzaraki, V.; van der Heijden, W.; Gacesa, R.; Weersma, R. K.; Zhernakova, A.; Vandekerckhove, L.; de Mast, Q.; Joosten, L. A.; Netea, M.; van der Ven, A.; Fu, J.

10.1101/2022.04.21.489050 — microbiology — Posted on 2022-04-22

1005 Targeted single-cell genomics reveals novel host adaptation strategies of the symbiotic bacteria Endozoicomonas in Acropora tenuis coral

Ide, K.; Nishikawa, Y.; Maruyama, T.; Tsukada, Y.; Kogawa, M.; Takeda, H.; Wagatsuma, R.; Miyaoka, R.; Nakano, Y.; Kinjo, K.; Ito, M.; Hosokawa, M.; Yura, K.; Suda, S.; Takeyama, H.

10.1101/2022.04.22.489146 — microbiology — Posted on 2022-04-22

1006 Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX

Cheng, M. I.; Riggan, L.; Li, J. H.; Tafti, R. Y.; Chin, S.; Ma, F.; Pellegrini, M.; Hrncir, H.; Arnold, A. P.; O'Sullivan, T. E.; Su, M. A.

10.1101/2022.04.21.489076 — immunology — Posted on 2022-04-22

1007 enclone: precision clonotyping and analysis of immune receptors

Jaffe, D. B.; Shahi, P.; Adams, B. A.; Chrisman, A. M.; Finnegan, P. M.; Raman, N.; Royall, A. E.; Tsai, F.; Vollbrecht, T.; Reyes, D. S.; McDonnell, W. J.

10.1101/2022.04.21.489084 — immunology — Posted on 2022-04-22

1008 VelcroVax: a bolt-on vaccine platform technology improves antibody titres against a viral glycoprotein in mice

Stonehouse, N. J.; Kingston, N. J.; Grehan, K.; Snowden, J. S.; Hassall, M.; Alzahrani, J.; Paesen, G. C.; Sherry, L.; Hayward, C. R.; Roe, A.; Stephen, S.; Tomlinson, D. C.; Zeltina, A.; Doores, K. J.; Ranson, N. A.; Stacey, M.; Page, M.; Rose, N. J.; Bowden, T. A.; Rowlands, D. J.

10.1101/2022.04.22.489148 — immunology — Posted on 2022-04-22

1009 Cluster-Based Inference for Memory-Based Cognition

Penny, W. D.; Menghi, N.; Renoult, L.

10.1101/2022.04.22.489185 — neuroscience — Posted on 2022-04-22

1010 Heavy metals in moss guide environmental justice investigation: a case study using community science in Seattle, WA, USA

Jovan, S.; Zuidema, C.; Derrien, M. M.; Bidwell, A. L.; Brinkley, W.; Smith, R. J.; Blahna, D.; Barnhill, R.; Gould, L.; Rodriguez, A. J.; Amacher, M. C.; Abel, T. D.; Lopez, P.

10.1101/2022.04.20.488941 — scientific communication and education — Posted on 2022-04-22

1011 Deceptive learning in histopathology

Shahamatdar, S.; Saeed-Vafa, D.; Linsley, D.; Khalil, F.; Lovinger, K. L.; Li, L.; McLeod, H. L.; Ramachandran, S.; Serre, T.

10.1101/2022.04.21.489110 — pathology — Posted on 2022-04-22

1012 Does fatigue influence joint-specific work and ground force production during the first steps of maximal accelerative running?

Vial, S.; Cochrane Wilkie, J.; Turner, M.; Scanlan, M.; Blazevich, A. J.

10.1101/2022.04.21.489102 — biophysics — Posted on 2022-04-22

1013 Genetic variation in heat tolerance of the coral Platygyra daedalea indicates the potential for adaptation to ocean warming

Elder, H.; Weis, V.; Montalvo-Proano, J.; Mocellin, V. J. L.; Baird, A.; Meyer, E.; Bay, L. K.

10.1101/2020.10.13.337089 — evolutionary biology — Posted on 2022-04-22

1014 Gene Transfer based Phylogenetics: Analytical Expressions and Additivity via Birth/Death Theory

Katriel, G.; Mahanaymi, U.; Koutschan, C.; Zeilberger, D.; Steel, M.; Snir, S.

10.1101/2022.04.21.489106 — evolutionary biology — Posted on 2022-04-22

1015 Benchmarking brain organoid recapitulation of fetal corticogenesis

Cheroni, C.; Trattaro, S.; Caporale, N.; Lopez-Tobon, A.; Tenderini, E.; Troglio, F.; Gabriele, M.; Bardini Bressan, R.; Pollard, S.; Gibson, W.; Testa, G.

10.1101/2022.04.22.488753 — developmental biology — Posted on 2022-04-22

1016 Learning High-Order Interactions for Polygenic Risk Prediction

Massi, M. C.; Franco, N. R.; Manzoni, A.; Paganoni, A. M.; Park, H. A.; Hoffmeister, M.; Brenner, H.; Chang-Claude, J.; Ieva, F.; Zunino, P.

10.1101/2022.04.22.489134 — genomics — Posted on 2022-04-22

1017 Great tits differ in glucocorticoid plasticity in response to spring temperature

Hau, M.; Deimel, C.; Moiron, M.

10.1101/2022.04.21.489013 — physiology — Posted on 2022-04-22

1018 Odorant molecular feature mining by diverse deep neural networks for prediction of odor perception categories

Shang, L.; Liu, C.; Tang, F.; Chen, B.; Liu, L.; Hayashi, K.

10.1101/2022.04.20.488977 — bioinformatics — Posted on 2022-04-22

1019 Computational modeling of deep tissue heating by an automatic thermal massage bed: predicting the effects on circulation

Dmochowski, J. P.; Khadka, N.; Cardoso, L.; Menenes, E.; Jin, Y.; Bikson, M.

10.1101/2022.04.21.488942 — bioengineering — Posted on 2022-04-22

1020 Accurate and sensitive mutational signature analysis with MuSiCal

Jin, H.; Gulhan, D. C.; Ben-Isvy, D.; Geng, D.; Ljungstrom, V.; Park, P. J.

10.1101/2022.04.21.489082 — genomics — Posted on 2022-04-22

1021 Resilience in soil bacterial communities of the boreal forest from one to five years after wildfire across a severity gradient

Whitman, T.; Woolet, J.; Sikora, M.; Johnson, D. B.; Whitman, E.

10.1101/2022.04.21.487669 — ecology — Posted on 2022-04-22

1022 FACT regulates pluripotency through distal regulation of gene expression in murine embryonic stem cells

Klein, D. C.; Lardo, S. M.; McCannell, K. N.; Hainer, S. J.

10.1101/2021.07.30.454509 — molecular biology — Posted on 2022-04-22

1023 Glucagon-Like Peptide-1 Receptor Activation Stimulates PKA-Mediated Phosphorylation of Raptor and this Contributes to the Weight Loss Effects of Liraglutide

Le, T. D. V.; Liu, D.; Ellis, B. J.; Collins, S.; Ayala, J. E.

10.1101/2022.04.21.489078 — physiology — Posted on 2022-04-22

1024 CAPG: Comprehensive Allopolyploid Genotyper

Kulkarni, R.; Zhang, Y.; Cannon, S. B.; Dorman, K. S.

10.1101/2022.04.21.488948 — bioinformatics — Posted on 2022-04-22

1025 OptoRheo: Simultaneous in situ micro-mechanical sensing and 3D imaging of live cell cultures

Mendonca, T.; Lis-Slimak, K.; Matheson, A. B.; Smith, M. G.; Anane-Adjei, A. B.; Cavanagh, R.; Paterson, L.; Dalgarno, P. A.; Alexander, C.; Tassieri, M.; Merry, C. L. R.; Wright, A. J.

10.1101/2022.04.21.489042 — bioengineering — Posted on 2022-04-22

1026 A Fast, Provably Accurate Approximation Algorithm for Sparse Principal Component Analysis Reveals Human Genetic Variation Across the World

Chowdhury, A.; Bose, A.; Zhou, S.; Woodruff, D. P.; Drineas, P.

10.1101/2022.04.21.489052 — genomics — Posted on 2022-04-22

1027 Population genomics of the island thrush elucidates one of earth's great archipelagic radiations

Reeve, A. H.; Gower, G.; Pujolar, J. M.; Smith, B. T.; Petersen, B.; Olsson, U.; Haryoko, T.; Koane, B.; Maiah, G.; Blom, M. P. K.; Ericson, P. G. P.; Irestedt, M.; Racimo, F.; Jonsson, K. A.

10.1101/2022.04.21.488757 — evolutionary biology — Posted on 2022-04-22

1028 Divergent acute versus prolonged in vivo GLP-1R responses in β-arrestin 2-deleted primary beta cells

Bitsi, S.; Manchanda, Y.; ElEid, L.; Mohamed, N.; Hansen, B.; Suba, K.; Rutter, G. A.; Salem, V.; Jones, B.; Tomas, A.

10.1101/2022.04.21.489075 — cell biology — Posted on 2022-04-22

1029 Osteocalcin binds to the GPRC6A Venus fly trap allosteric site to positively modulate GPRC6A signaling

Agarwal, R.; Pi, M.; Ye, R.; Smith, M. D.; Smith, J. C.; Quarles, L. D.

10.1101/2022.02.15.480526 — molecular biology — Posted on 2022-04-22

1030 A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors

Wcisel, D. J.; Dornburg, A.; McConnell, S. C.; Hernandez, K. M.; Andrade, J.; de Jong, J. L. O.; Litman, G. W.; Yoder, J. A.

10.1101/2022.04.21.489081 — immunology — Posted on 2022-04-22

1031 The Neuroanatomy of Speech Processing: A Large-Scale Lesion Study

Rogalsky, C.; Basilakos, A.; Rorden, C.; Pillay, S.; LaCroix, A. N.; Keator, L.; Mickelsen, S.; Anderson, S. W.; Love, T.; Fridriksson, J.; Binder, J.; Hickok, G.

10.1101/2020.04.02.022822 — neuroscience — Posted on 2022-04-22

1032 Dissection of a sensorimotor circuit that regulates aversion to odors and pathogenic bacteria in C. elegans by whole-brain simulation

Filipowicz, A.; Lalsiamthara, J.; Aballay, A.

10.1101/2022.04.21.489073 — neuroscience — Posted on 2022-04-22

1033 GABAergic regulation of cell proliferation within the adult mouse spinal cord

New, L.; Yanagawa, Y.; McConkey, G. A.; Deuchars, J.; Deuchars, S.

10.1101/2022.04.21.489053 — neuroscience — Posted on 2022-04-22

1034 Systems-level identification of key transcription factors in immune cell specification

Liu, c.; Omilusik, K.; Toma, C.; Kurd, N. S.; Chang, J. T.; Goldrath, A. W.; Wang, W.

10.1101/2022.04.21.489000 — systems biology — Posted on 2022-04-22

1035 Architecture and Assembly Mechanism of Human LACTB

Bennett, J. A.; Steward, L. R.; Voss, A.; Rudolph, J.; Aydin, H.

10.1101/2022.04.21.489104 — biophysics — Posted on 2022-04-22

1036 UMINT: Unsupervised Neural Network For Single Cell Multi-Omics Integration

Maitra, C.; Seal, D. B.; Das, V.; De, R. K.

10.1101/2022.04.21.489041 — bioinformatics — Posted on 2022-04-22

1037 Evaluating risk-taking behaviors in Lycosidae: are the nutritional benefits of sugar water worth the risk of predation?

Woyak, L.; McCullagh, E. A.; Wiggins, W. D.

10.1101/2022.04.21.489068 — animal behavior and cognition — Posted on 2022-04-22

1038 Sign inversion in selection on ploidy

Raynes, Y.; Weinreich, D. M.

10.1101/2021.10.26.465943 — evolutionary biology — Posted on 2022-04-22

1039 Rising Temperature Drives Tipping Points in Mutualistic Networks

Bhandary, S.; Deb, S.; Dutta, P. S.

10.1101/2022.04.21.488997 — ecology — Posted on 2022-04-22

1040 Landscape change and alien invasions drive shifts in native lady beetle communities over a century

Perry, K. I.; Bahlai, C. I.; Assal, T. J.; Riley, C. B.; Turo, K. J.; Taylor, L.; Radl, J.; Delgado de la flor, Y. A.; Sivakoff, F. S.; Gardiner, M. M.

10.1101/2022.04.21.489069 — ecology — Posted on 2022-04-22

1041 Why the architecture of environmental fluctuation matters for fitness

Park, J. S.; Felmy, A.

10.1101/2022.04.21.489085 — ecology — Posted on 2022-04-22

1042 Fluid manipulations uncover mechanosensation for zebrafish left-right establishment during one-hour time interval

Sampaio, P.; Pestana, S.; Guerrero, A.; Telley, I. A.; Smith, D. J.; Lopes, S. S.

10.1101/2022.04.21.489023 — developmental biology — Posted on 2022-04-22

1043 Combining Stem Cell Rejuvenation and Senescence Targeting to Synergistically Extend Lifespan

Kaur, P.; Otgonbaatar, A.; Ramamoorthy, A.; Chua, E. H. Z.; Harmston, N.; Gruber, J.; Towlinski, N. S.

10.1101/2022.04.21.488994 — developmental biology — Posted on 2022-04-22

1044 Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures

Brabec, J. L.; Ouardouz, M.; Mahoney, J. M.; Scott, R. C.; Hernan, A. E.

10.1101/2022.04.21.489067 — neuroscience — Posted on 2022-04-22

1045 Tbx3 is required for mammalian retinal angiogenesis.

Derbyshire, M.; Akula, S.; Wong, A.; Rawlins, K.; Voura, E. B.; Brunken, W. J.; Zuber, M. E.; Moon, A. M.; Viczian, A. S.

10.1101/2022.04.20.488944 — neuroscience — Posted on 2022-04-22

1046 Motor pattern generation is robust to neural network anatomical imbalance favoring inhibition but not excitation

de Graaf, M. L.; Mochizuki, L.; Thies, F.; Wagner, H.; Le Mouel, C.

10.1101/2022.04.21.489087 — neuroscience — Posted on 2022-04-22

1047 Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis

Ma, Q.; Yang, L.; Tolentino, K.; Zhao, Y.; Lizenburger, U. M.; Shi, Q.; Zhu, L.; Tsai, M.-C.; Chen, J.-A.; Lai, I.; Zeng, H.; Li, L.; Chang, H.

10.1101/2022.04.21.488980 — cancer biology — Posted on 2022-04-22

1048 Point Mutations in SARS-CoV-2 Variants Induce Long-Range Dynamical Perturbations in Neutralizing Antibodies

Ray, D.; Quijano, R. N.; Andricioaei, I.

10.1101/2021.08.13.456317 — biophysics — Posted on 2022-04-22

1049 In silico identification of novel peptides as potential modulators of Aβ42 Amyloidogenesis

Kundal, K.; Paramasivam, S.; Mitra, A.; Sarkar, N.

10.1101/2022.04.20.488983 — bioinformatics — Posted on 2022-04-22

1050 Modelling eNvironment for Isoforms (MoNvIso): A general platform to predict structural determinants of protein isoforms in genetic diseases

Oliva, F.; Musiani, F.; Giorgetti, A.; De Rubeis, S.; Sorokina, O.; Armstrong, J. D.; Carloni, P.; Ruggerone, P.

10.1101/2022.04.21.489045 — bioinformatics — Posted on 2022-04-22

1051 Detecting intragenic trans-splicing events with hybrid transcriptome sequencing in cancer cells

Chen, Y.-C.; Chen, C.-Y.; Chiang, T.-W.; Chan, M.-H.; Hsiao, M.; Ke, H.-M.; Tsai, I. J.; Chuang, T.-J.

10.1101/2022.04.21.489006 — bioinformatics — Posted on 2022-04-22

1052 DrugRepo: A novel approach to repurpose a huge collection of compounds based on chemical and genomic features

Wang, Y.; Aldahdooh, J.; hu, y.; Yang, H.; vaha-koskela, M.; Tang, J.; Tanoli, Z.

10.1101/2022.04.21.488995 — bioinformatics — Posted on 2022-04-22

1053 Xlink Mapping and AnalySis (XMAS) - Smooth Integrative Modeling in ChimeraX

Lagerwaard, I. M.; Albanese, P.; Jankevics, A.; Scheltema, R. A.

10.1101/2022.04.21.489026 — bioinformatics — Posted on 2022-04-22

1054 A comprehensive Bioconductor ecosystem for the design of CRISPR guide RNAs across nucleases and technologies

Hoberecht, L.; Perampalam, P.; Lun, A.; Fortin, J.-P.

10.1101/2022.04.21.488824 — bioinformatics — Posted on 2022-04-22

1055 Mitochondrial effects on fertility and longevity in Tigriopus californicus contradict predictions of the mother's curse hypothesis

Watson, E. T.; Flanagan, B. A.; Pascar, J. A.; Edmands, S.

10.1101/2022.04.20.488069 — evolutionary biology — Posted on 2022-04-22

1056 Seasonal movement of royal chambers: where are the kings and queens of temperate termites in winter?

Takata, M.; Konishi, T.; Nagai, S.; Nozaki, T.; Tasaki, E.; Matsuura, K.

10.1101/2022.04.21.488984 — ecology — Posted on 2022-04-22

1057 Mitigating pseudoreplication and bias in resource selection functions with autocorrelation-informed weighting

Alston, J. M.; Fleming, C. H.; Kays, R.; Streicher, J. P.; Downs, C. T.; Ramesh, T.; Calabrese, J. M.

10.1101/2022.04.21.489059 — ecology — Posted on 2022-04-22

1058 Macroecological variation in movement profiles: body size does not explain it all

Straus, S.; Forbes, C.; Little, C. J.; Germain, R. M.; Main, D. A.; O'Connor, M. I.; Thompson, P. L.; Ford, A. T.; Gravel, D.; Guzman, L. M.

10.1101/2022.04.21.489049 — ecology — Posted on 2022-04-22

1059 Atlantic cod as an indicator of rapid climate change

Choi, J. S.

10.1101/2022.04.21.488963 — ecology — Posted on 2022-04-22

1060 Mind the gap: decoding decreases in tonic firing in populations of spiking neurons

Durian, S.; Agrios, M.; Schwartz, G. W.

10.1101/2022.04.21.488999 — neuroscience — Posted on 2022-04-22

1061 Upregulated Ca2+ release from the endoplasmic reticulum leads to impaired presynaptic function in Alzheimer's disease

Adeoye, T.; Shah, S. I.; Demuro, A.; Rabson, D. A.; Ullah, G.

10.1101/2022.04.21.489060 — neuroscience — Posted on 2022-04-22

1062 Neural resources shift under Methylphenidate: a computational approach to examine anxiety-cognition interplay

Saggar, M.; Bruno, J.; Gaillard, C.; Claudino, L.; Ernst, M.

10.1101/2022.04.21.489066 — neuroscience — Posted on 2022-04-22

1063 A three-photon head-mounted microscope for imaging all layers of visual cortex in freely moving mice.

Klioutchnikov, A.; Wallace, D. J.; Sawinski, J.; Voit, K.-M.; Groemping, Y.; Kerr, J. N.

10.1101/2022.04.21.489051 — neuroscience — Posted on 2022-04-22

1064 Bridging scales from spiking activity to the local field potential through latent dynamics

Sederberg, A.; Pala, A.; Stanley, G. B.

10.1101/2022.04.21.489039 — neuroscience — Posted on 2022-04-22

1065 The nanoCUT&RUN technique visualizes telomeric chromatin in Drosophila

chen, t.; Wei, X.; Courret, C.; cui, m.; Cheng, L.; wu, j.; Ahmad, K.; Larracuente, A. M.; rong, y.

10.1101/2022.04.20.488892 — genetics — Posted on 2022-04-22

1066 Whole-brain modeling explains the context-dependent effects of cholinergic neuromodulation

Coronel-Oliveros, C.; Giessing, C.; Medel, V.; Cofre, R.; Orio, P.

10.1101/2022.03.21.485145 — neuroscience — Posted on 2022-04-22

1067 Hand and face somatotopy shown using MRI-safe vibrotactile stimulation with a novel Soft Pneumatic Actuator (SPA)-Skin interface

Kikkert, S.; Sonar, H. A.; Freund, P.; Paik, J.; Wenderoth, N.

10.1101/2021.10.27.465604 — neuroscience — Posted on 2022-04-22

1068 Computing Minimal Boolean Models of Gene Regulatory Networks

Karlebach, G.; Robinson, P. N.

10.1101/2021.05.22.445266 — systems biology — Posted on 2022-04-22

1069 Paternal knockdown of tRNA (cytosine-5-)-methyltransferase (Dnmt2) increases offspring susceptibility to infection in red flour beetles

Schulz, N. K. E.; Mohamed, F. F.; Lo, L. K.; Peuss, R.; de Buhr, M. F.; Kurtz, J.

10.1101/422063 — evolutionary biology — Posted on 2022-04-22

1070 Reduced glutathione decreases cell adhesion and increases cell volume.

Geloen, A.; Danty, E.

10.1101/2021.07.30.454460 — cell biology — Posted on 2022-04-22

1071 Apurinic/apyrimidinic nuclease 1 drives genomic evolution contributing to chemoresistance and tumorigenesis in solid tumor

Kumar, S.; Zhao, J.; Talluri, S.; Leutz Buon, L.; Mu, S.; Potluri, B.; Liao, C.; Shi, J.; Chakraborty, C.; Gonzalez, G. B.; Tai, Y.-T.; Patel, J.; Pal, J.; Mashimo, H.; Samur, M. K.; Munshi, N. C.; Shammas, M. A.

10.1101/2022.04.20.488830 — cancer biology — Posted on 2022-04-22

1072 Architecture and Assembly Mechanism of Human LACTB

Aydin, H.; Bennett, J. A.; Steward, L. R.; Voss, A.; Rudolph, J.

10.1101/2022.04.21.489104 — biophysics — Posted on 2022-04-22

1073 Joint copy number and mutation phylogeny reconstruction fromsingle-cell amplicon sequencing data

Sollier, E.; Kuipers, J.; Beerenwinkel, N.; Takahashi, K.; Jahn, K.

10.1101/2022.01.06.475205 — bioinformatics — Posted on 2022-04-22

1074 Evolution and co-evolution of the suck behaviour, a postcopulatory female resistance trait that manipulates received ejaculate

Singh, P.; Brand, J. N.; Schärer, L.

10.1101/2022.04.13.485945 — evolutionary biology — Posted on 2022-04-22

1075 Sexual coercion in a natural mandrill population

Smit, N.; Baniel, A.; Roura-Torres, B.; Amblard-Rambert, P.; Charpentier, M. J. E.; Huchard, E.

10.1101/2022.02.07.479393 — ecology — Posted on 2022-04-22

1076 Ret loss-of-function decreases enteric neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system development

Vincent, E.; Chatterjee, S.; Cannon, G. H.; Auer, D.; Ross, H.; Chakravarti, A.; Goff, L. A.

10.1101/2021.12.28.474390 — developmental biology — Posted on 2022-04-22

1077 Pallidal neuromodulation of the explore/exploit trade-off in decision-making

de Almeida Marcelino, A.; Gray, O.; Al-Fatly, B.; Steele, D.; Kuhn, A.; Gilbertson, T.

10.1101/2022.04.21.489010 — neuroscience — Posted on 2022-04-22

1078 Molecular-enriched functional connectivity in the human brain using multiband multi-echo simultaneous ASL/BOLD fMRI

Dipasquale, O.; Cohen, A.; Martins, D.; Zelaya, F.; Turkheimer, F. E.; Veronese, M.; Mehta, M. A.; Williams, S. C.; Yang, B.; Banerjee, S.; Wang, Y.

10.1101/2022.04.21.489018 — neuroscience — Posted on 2022-04-22

1079 Cerebral activity in monkeys Papio anubis during the perception of conspecific and heterospecific agonistic vocalizations: A functional Near Infrared Spectroscopy study

Debracque, C.; Gruber, T.; Lacoste, R.; Meguerditchian, A.; Grandjean, D.

10.1101/2022.04.21.489037 — neuroscience — Posted on 2022-04-22

1080 Transient developmental increase in cortical projections to amygdala GABAergic neurons contribute to circuit dysfunction following early life stress

Haikonen, J.; Englund, J.; Amarilla, S. P.; Kharybina, Z.; Shintyapina, A.; Kegler, K.; Saez Garcia, M.; Atanasova, T.; Taira, T.; Hartung, H.; Lauri, S. E.

10.1101/2022.04.21.489031 — neuroscience — Posted on 2022-04-22

1081 Adaptive nanopore sequencing on miniature flow cell detects extensive antimicrobial resistence

Viehweger, A.; Marquet, M.; Hölzer, M.; Dietze, N.; Pletz, M.; Brandt, C.

10.1101/2021.08.29.458107 — microbiology — Posted on 2022-04-21

1082 Improved assessments of milk microbiota composition via sample preparation and DNA extraction methods

Marco, M. L.; Xue, Z.

10.1101/2022.04.21.489028 — microbiology — Posted on 2022-04-21

1083 Diversity of Secretion System Apparatus in Tomato Wilt Causing Ralstonia solanacearum Strains: a Comparative Analysis Using in-silico Approach

Banerjee, G.; Chatterjee, S.; Banerjee, P.; Chattopadhyay, P.

10.1101/2022.04.21.489029 — microbiology — Posted on 2022-04-21

1084 McaA and McaB control the dynamic positioning of a bacterial magnetic organelle

Wan, J.; Monteil, C. L.; Taoka, A.; Ernie, G.; Park, K.; Amor, M.; Taylor-Cornejo, E.; Lefevre, C. T.; Komeili, A.

10.1101/2022.04.21.485668 — microbiology — Posted on 2022-04-21

1085 Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination

Wheeler, R.; Bastos, P. A. D.; Disson, O.; Rifflet, A.; Spielbauer, J.; Lecuit, M.; Boneca, I. G.

10.1101/2022.04.20.488924 — microbiology — Posted on 2022-04-21

1086 Comparative transcriptomics and metabolomics reveal specialized metabolite drought stress responses in switchgrass (Panicum virgatum L.)

Tiedge, K. J.; Li, X.; Merrill, A. T.; Davisson, D. L.; Chen, Y.; Yu, P.; Tantillo, D. J.; Last, R.; Zerbe, P.

10.1101/2022.04.20.488672 — plant biology — Posted on 2022-04-21

1087 A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer

Kelly, M. R.; Wisniewska, K.; Regner, M. J.; Lewis, M. W.; Perreault, A. A.; Davis, E. S.; Phanstiel, D. H.; Parker, J. S.; Franco, H. L.

10.1101/2022.04.08.487699 — cancer biology — Posted on 2022-04-21

1088 Improving the assessment of deep learning models in the context of drug-target interaction prediction

Torrisi, M.; de la Vega de Leon, A.; Climent, G.; Loos, R.; Panjkovich, A.

10.1101/2022.04.20.488898 — bioinformatics — Posted on 2022-04-21

1089 Private and sub-family specific mutations of founder haplotypes in the BXD family reveal phenotypic consequences relevant to health and disease

Ashbrook, D. G.; Sasani, T. A.; Maksimov, M.; Gunturkun, M. H.; Ma, N.; Villani, F.; Ren, Y.-y.; Rothschild, D.; Chen, H.; Lu, L.; Colonna, V.; Dumont, B. L.; Harris, K.; Gymrek, M.; Pritchard, J. K.; Palmer, A. A.; Williams, R. W.

10.1101/2022.04.21.489063 — genomics — Posted on 2022-04-21

1090 Breakpoint models shown no evidence of thresholds in recreational response to increasing wildfire smoke in the American West

Clark, M.; Killion, A.; Williamson, M. A.; Hillis, V.

10.1101/2022.04.21.489032 — ecology — Posted on 2022-04-21

1091 Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimer disease

Brymer, K. J.; Hurley, E. P.; Barron, J. C.; Mukherjee, B.; Barnes, J. R.; Nafar, F.; Parsons, M. P.

10.1101/2022.04.21.489062 — neuroscience — Posted on 2022-04-21

1092 Neuromuscular denervation and deafferentation but not motor neuron death are disease features in the Smn 2B/- mouse model of SMA

Carlini, M. J.; Triplett, M. K.; Pellizzoni, L.

10.1101/2022.04.21.489030 — neuroscience — Posted on 2022-04-21

1093 Low temperature induced quiescence in parasitoids Trichogramma evanescens Westwood and Trichogramma chilonis Ishii reared on Plodia interpunctella (Hübner): Its utilization as quality control for mass rearing

Hasan, M. M.; Parvin, M. N.; Athanassiou, C. h. C.

10.1101/2022.04.21.489033 — zoology — Posted on 2022-04-21

1094 The physics of liquid-to-solid transitions in multi-domain protein condensates

Ranganathan, S.; Shakhnovich, E.

10.1101/2021.11.15.468745 — biophysics — Posted on 2022-04-21

1095 Yield Stress and Creep Control Depot Formation and Persistence of Injectable Hydrogels Following Subcutaneous Administration

Jons, C. K.; Grosskopf, A. K.; Baillet, J.; Yan, J.; Klich, J. H.; Appel, E. A.

10.1101/2022.04.20.488959 — bioengineering — Posted on 2022-04-21

1096 A novel camera trap design for studying wildlife in mountain glacier ecosystems yields new insight for glacier biodiversity in the Pacific Northwest, USA

Hotaling, S.; Boersma, J.; Paprocki, N. A.; Anderson, A.; Whiles, L.; Ogburn, L.; Kasper, S.; White, C.; Thornton, D. H.; Wimberger, P.

10.1101/2021.12.10.472172 — ecology — Posted on 2022-04-21

1097 Kasugamycin is a novel chitinase 1 inhibitor with strong antifibrotic effects on pulmonary fibrosis

Lee, J.-H.; Lee, C.-M.; Lee, J. H.; Kim, M.-O.; Park, J. W.; Kamle, S.; Akosman, B.; Herzog, E. L.; Peng, X. Y.; Elias, J. A.; Lee, C. G.

10.1101/2021.02.25.432796 — immunology — Posted on 2022-04-21

1098 Age-associated B cells are long-lasting effectors that restrain reactivation of latent γHV68

Mouat, I. C.; Shanina, I.; Horwitz, M. S.

10.1101/2021.12.29.474434 — immunology — Posted on 2022-04-21

1099 Individual differences in frontoparietal plasticity in humans

Boroshok, A. L.; Park, A. T.; Fotiadis, P.; Velasquez, G. H.; Tooley, U. A.; Simon, K. R.; Forde, J. C. P.; Delgado Reyes, L. M.; Tisdall, M. D.; Bassett, D. S.; Cooper, E. A.; Mackey, A. P.

10.1101/2021.11.08.467831 — neuroscience — Posted on 2022-04-21

1100 Dynamic task-belief is an integral part of decision-making

Xue, C.; Kramer, L. E.; Cohen, M. R.

10.1101/2021.04.05.438491 — neuroscience — Posted on 2022-04-21

1101 Thermodynamic coupling between neighboring binding sites in homo-oligomeric ligand sensing proteins from mass resolved ligand dependent population distributions

Li, W.; Norris, A. S.; Lichtenthal, K.; Kelly, S.; Ihms, E. C.; Gollnick, P.; Wysocki, V. H.; Foster, M. P.

10.1101/2022.03.19.484990 — biophysics — Posted on 2022-04-21

1102 Role of non-specific interactions in the phase-separation and maturation of macromolecules

Krishnan, R.; Ranganathan, S.; Maji, S. K.; Padinhateeri, R.

10.1101/2021.07.25.453674 — biophysics — Posted on 2022-04-21

1103 HMMploidy: inference of ploidy levels from short-read sequencing data

Soraggi, S.; Rhodes, J.; Altinkaya, I.; Tarrant, O.; Balloux, F.; Fisher, M. C.; Fumagalli, M.

10.1101/2021.06.29.450340 — bioinformatics — Posted on 2022-04-21

1104 Fast, accurate antibody structure prediction from deep learning on massive set of natural antibodies

Ruffolo, J. A.; Chu, L.-S.; Mahajan, S. P.; Gray, J. J.

10.1101/2022.04.20.488972 — bioinformatics — Posted on 2022-04-21

1105 Establishing farm dust as a useful viral metagenomic surveillance matrix

Kwok, K. T. T.; de Rooij, M. M. T.; Messink, A. B.; Wouters, I.; Smit, L. A. M.; Heederik, D.; Koopmans, M.; Phan, M. V.

10.1101/2021.03.09.434704 — evolutionary biology — Posted on 2022-04-21

1106 Drosophila immunity: The Drosocin gene encodes two host defence peptides with pathogen-specific roles

Hanson, M. A.; Kondo, S.; Lemaitre, B.

10.1101/2022.04.21.489012 — immunology — Posted on 2022-04-21

1107 Birth and Death in Terminal Complement Pathway

Sharma, A.; Gupta, S.; Patil, A. B.; Vijay, N.

10.1101/2022.04.21.489004 — immunology — Posted on 2022-04-21

1108 Synaptotagmin 7 docks synaptic vesicles for Doc2α-triggered asynchronous neurotransmitter release

Wu, Z.; Kusick, G. F.; Raychaudhuri, S.; Itoh, K.; Chapman, E. R.; Watanabe, S.

10.1101/2022.04.21.489101 — neuroscience — Posted on 2022-04-21

1109 rTg(TauP301L)4510 mice exhibit increased VGLUT1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular glutamate release

Taipala, E.; Pfitzer, J. C.; Hellums, M.; Reed, M.; Gramlich, M. W.

10.1101/2022.04.21.489047 — neuroscience — Posted on 2022-04-21

1110 Potato virus X -delivered CRISPR activation programs lead to strong endogenous gene induction and transient metabolic reprogramming in Nicotiana benthamiana.

Selma, S.; Gianoglio, S.; Uranga, M.; Vazquez-Vilar, M.; Espinosa-Ruiz, A.; Drapal, M.; Fraser, P. D.; Daros, J.-A.; Orzaez, D.

10.1101/2022.04.21.489058 — synthetic biology — Posted on 2022-04-21

1111 A platform for efficient establishment, expansion and drug response profiling of high-grade serous ovarian cancer organoids

Senkowski, W.; Gall-Mas, L.; Falco, M. M.; Li, Y.; Lavikka, K.; Kriegbaum, M. C.; Oikkonen, J.; Bulanova, D.; Pietras, E. J.; Vossgröne, K.; Chen, Y.-J.; Erkan, E. P.; Gronning Hog, M. K.; Larsen, I. M.; Lamminen, T.; Kaipio, K.; Huvila, J.; Virtanen, A.; Engelholm, L. H.; Christiansen, P.; Santoni-Rugiu, E.; Huhtinen, K.; Carpen, O.; Hynninen, J.; Hautaniemi, S.; Vähärautio, A.; Wennerberg, K.

10.1101/2022.04.21.489027 — cancer biology — Posted on 2022-04-21

1112 DiffBrainNet: differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions

Gerstner, N.; Krontira, A. C.; Cruceanu, C.; Roeh, S.; Puetz, B.; Sauer, S.; Rex-Haffner, M.; Schmidt, M. V.; Binder, E. B.; Knauer-Arloth, J.

10.1101/2022.04.21.489034 — genomics — Posted on 2022-04-21

1113 Spatial chromatin accessibility sequencing resolves next-generation genome architecture

Xie, Y.; Li, Y.; Ruan, F.; Zhang, C.; Chen, Z.; Xie, Z.; Weng, Z.; Chen, W.; Chen, W.; Fang, Y.; Sun, Y.; Guo, M.; Wang, J.; Wang, H.; Tang, C.

10.1101/2022.04.21.489011 — genomics — Posted on 2022-04-21

1114 Conservation and divergence of canonical and non-canonical imprinting in murids

Richard Albert, J.; Kobayashi, T.; Inoue, A.; Monteagudo-Sanchez, A.; Kumamoto, S.; Takashima, T.; Miura, A.; Oikawa, M.; Miura, F.; Takada, S.; Hirabayashi, M.; Korthauer, K.; Kurimoto, K.; Greenberg, M. V.; Lorincz, M. C.; Kobayashi, H.

10.1101/2022.04.21.488764 — genomics — Posted on 2022-04-21

1115 Reporter gene assays and chromatin-level assays define substantially non-overlapping sets of enhancer sequences

Lindhorst, D.; Halfon, M. S.

10.1101/2022.04.21.489091 — genomics — Posted on 2022-04-21

1116 Regulation of Liprin-α phase separation by CASK is disrupted by a mutation in its CaM kinase domain

Tibbe, D.; Ferle, P.; Krisp, C.; Nampoothiri, S.; Mirzaa, G.; Assaf, M.; Parikh, S.; Kutsche, K.; Kreienkamp, H.-J.

10.1101/2022.04.21.489014 — genetics — Posted on 2022-04-21

1117 Maintenance of quantitative genetic variance in complex, multi-trait phenotypes: The contribution of rare, large effect variants in two Drosophila species

Hine, E.; Runcie, D. E.; Allen, S. L.; Wang, Y.; Chenoweth, S. F.; Blows, M. W.; McGuigan, K.

10.1101/2022.04.21.488876 — genetics — Posted on 2022-04-21

1118 Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis

Taylor, H. J.; Hung, Y.-H.; Narisu, N.; Erdos, M. R.; Kanke, M.; Yan, T.; Grenko, C. M.; Swift, A. J.; Bonnycastle, L. L.; Sethupathy, P.; Collins, F. S.; Taylor, D. L.

10.1101/2022.04.21.489048 — genetics — Posted on 2022-04-21

1119 Rapid evolution of sex role specialization in a hermaphrodite under sex-limited selection

Norden, A. K.; Ramm, S. A.; Abbott, J. K.

10.1101/2022.04.21.489077 — evolutionary biology — Posted on 2022-04-21

1120 FGF signaling promotes precursor spreading for adult adipogenesis in Drosophila

Lei, Y.; Huang, Y.; Yang, K.; Cao, X.; Song, Y.; Martin-Blanco, E.; Pastor-Pareja, J. C.

10.1101/2022.04.21.489019 — developmental biology — Posted on 2022-04-21

1121 CLN7 mutation causes aberrant redistribution of protein isoforms and contributes to Batten disease pathobiology

Sharaireh, A.; Guevara Ferrer, M.; Herranz-Martin, S.; Garcia-Macia, M.; Philips, A.; Tierney, A.; Hughes, M. P.; Coombe-Tennant, O.; Nelvagel, H.; Burrows, A. E.; Fielding, S.; FitzPatrick, L. M.; Thornton, C. D.; Storch, S.; Mole, S. E.; Dowsey, A.; Unwin, R.; Bolanos, J. P.; Rahim, A. A.; McKay, T. R.

10.1101/2022.04.21.488782 — cell biology — Posted on 2022-04-21

1122 RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription

Abuhashem, A.; Chivu, A. G.; Zhao, Y.; Rice, E. J.; Siepel, A.; Danko, C. G.; Hadjantonakis, A.-K.

10.1101/2022.04.21.489065 — molecular biology — Posted on 2022-04-21

1123 Towards Synthetic PETtrophy: Engineering Pseudomonas putida for concurrent polyethylene terephthalate (PET) monomer metabolism and PET hydrolase expression

Brandenberg, O. F.; Schubert, O. T.; Kruglyak, L.

10.1101/2022.04.21.489007 — microbiology — Posted on 2022-04-21

1124 Disentangling the lipid divide: Identification of key enzymes for the biosynthesis of unusual Membrane-spanning and Ether lipids in Bacteria

Sahonero-Canavesi, D. X.; Siliakus, M.; Abdala Asbun, A.; Koenen, M.; von Meijenfeldt, F. A. B.; Boeren, S.; Bale, N. J.; Engelmann, J. C.; Fiege, K.; Strack van Schijndel, L.; Sinninghe Damste, J. S.; Villanueva, L.

10.1101/2022.04.21.487849 — microbiology — Posted on 2022-04-21

1125 Integrative assessment of the transcriptome and virome of the poultry red mite Dermanyssus gallinae.

Ribeiro, J. M.; Hartmann, D.; Bartosova-Sojkova, P.; Debat, H. J.; Moos, M.; Simek, P.; Fara, J.; Palus, M.; Kucera, M.; Hajdusek, O.; Sojka, D.; Kopacek, P.; Perner, J.

10.1101/2022.04.21.489001 — microbiology — Posted on 2022-04-21

1126 The licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks

marreddy, R. K. R.; Picker, J. A.; Phelps, G.; Powell, R. T.; Cherian, P.; Bowling, J.; Stephan, C. C.; Lee, R.; Hurdle, J. G.

10.1101/2022.04.20.488993 — microbiology — Posted on 2022-04-21

1127 The PqsE active site as a target for small molecule antimicrobial agents against Pseudomonas aeruginosa

Taylor, I. R.; Jeffrey, P. D.; Moustafa, D. A.; Goldberg, J. B.; Bassler, B. L.

10.1101/2022.04.21.489002 — microbiology — Posted on 2022-04-21

1128 The AraC/XylS protein MxiE and its co-regulator IpgC control a negative feedback loop in the transcriptional cascade that regulates type III secretion in Shigella flexneri

McKenna, J. A.; Karney, M. M.; Chan, D. K.; Weatherspoon-Griffin, N.; Becerra Larios, B.; Pilonieta, M. C.; Munson, G. P.; Wing, H. J.

10.1101/2022.04.20.488988 — microbiology — Posted on 2022-04-21

1129 Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability

Gorman, J.; Cheung, C. S.-F.; Duan, Z.; Sun, Y.; Wang, P.; Boyington, J. C.; Biju, A.; Bylund, T.; Cheng, C.; Ou, L.; Stephens, T.; Tsybovsky, Y.; Verardi, R.; Wang, S.; Yang, Y.; Zhang, B.; Zheng, C.; Zhou, T.; Mascola, J. R.; Ho, D. D.; Ho, M.; Kwong, P. D.

10.1101/2022.04.21.488985 — immunology — Posted on 2022-04-21

1130 Cholesterol binds the amphipathic helix of IFITM3 and regulates antiviral activity

Rahman, K.; Datta, S. A. K.; Jolley, A. A.; Compton, A. A.

10.1101/2022.04.21.488780 — immunology — Posted on 2022-04-21

1131 Explosive seed dispersal depends on SPL7 to ensure sufficient copper for localized lignin deposition via laccases

Perez-Anton, M.; Schneider, I.; Kroll, P.; Hofhuis, H.; Metzger, S.; Pauly, M.; Hay, A.

10.1101/2022.04.21.488998 — plant biology — Posted on 2022-04-21

1132 The kinase activity of the cancer stem cell marker DCLK1 drives gastric cancer progression by reprogramming the stromal tumor landscape

Afshar-Sterle, S.; Carli, A. L. E.; O'Keefe, R.; Tse, J.; Fischer, S.; Azimpour, A. I.; Baloyan, D.; Elias, L.; Thilakasiri, P.; Patel, O.; Ferguson, F. M.; Eissmann, M. F.; Chand, A. L.; Gray, N. S.; Busuttil, R.; Boussioutas, A.; Lucet, I.; Ernst, M.; Buchert, M.

10.1101/2022.04.21.489109 — cancer biology — Posted on 2022-04-21

1133 Peptide derived nanobody inhibits entry of SARS-CoV-2 variants

Mendon, N.; Ganie, R. A.; Kesarwani, S.; Dileep, D.; Sasi, S.; Lama, P.; Chandra, A.; Sirajuddin, M.

10.1101/2022.04.21.489021 — cell biology — Posted on 2022-04-21

1134 Rapid learning of predictive maps with STDP and theta phase precession

George, T. M.; de Cothi, W.; Stachenfeld, K.; Barry, C.

10.1101/2022.04.20.488882 — neuroscience — Posted on 2022-04-21

1135 Genome-wide identification and expression analysis of bHLH transcription factors reveal their putative regulatory effects on petal nectar spur development in Aquilegia

Li, X.; Huang, H.; Zhang, Z.-Q.

10.1101/2022.04.20.488976 — plant biology — Posted on 2022-04-21

1136 Linking cells across single-cell modalities by synergistic matching of neighborhood structure

Hristov, B.; Bilmes, J.; Noble, W. S.

10.1101/2022.04.20.488794 — genomics — Posted on 2022-04-21

1137 Mesostats - A multiplexed, low-cost, do-it-yourself continuous culturing system for experimental evolution of mesocosms

Hansson, E. M.; Childs, D. Z.; Beckerman, A. P.

10.1101/2022.04.20.488910 — evolutionary biology — Posted on 2022-04-21

1138 A chemically inducible muscle ablation system for zebrafish

Paulissen, E.; Martin, B. L.

10.1101/2022.04.20.488934 — developmental biology — Posted on 2022-04-21

1139 Candidatus Nealsonbacteria (OD1) in a methanogenic benzene-degrading enrichment culture is likely an ectosymbiotic biomass recycler

Chen, X.; Molenda, O.; Brown, C. T.; Toth, C. R. A.; Guo, S.; Luo, F.; Howe, J.; Nesbo, C. L.; He, C.; Montabana, E. A.; Cate, J. H. D.; Banfield, J. F.; Edwards, E. A.

10.1101/2022.04.20.488981 — microbiology — Posted on 2022-04-21

1140 Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

Belk, J.; Yao, W.; Ly, N.; Freitas, K.; Chen, Y.-T.; Shi, Q.; Valencia, A.; Shifrut, E.; Kale, N.; Yost, K.; Duffy, C.; Hwee, M.; Miao, Z.; Ashworth, A.; Mackall, C.; Marson, A.; Carnevale, J.; Vardhana, S.; Satpathy, A.

10.1101/2022.04.20.488974 — immunology — Posted on 2022-04-21

1141 Brain network integration, flexibility and quasicyclicity during task and rest.

Fransson, P.; Strindberg, M.

10.1101/2022.04.20.488888 — neuroscience — Posted on 2022-04-21

1142 Slowing of Frontocentral Beta Oscillations in Atypical Parkinsonism

Kroesche, M.; Kannenberg, S.; Butz, M.; Hartmann, C.; Florin, E.; Schnitzler, A.; Hirschmann, J.

10.1101/2022.04.19.488835 — neuroscience — Posted on 2022-04-21

1143 Full geroprotection from brief rapamycin treatment by persistently increased intestinal autophagy

Juricic, P.; Lu, Y.-X.; Leech, T.; Drews, L. F.; Paulitz, J.; Lu, J.; Nespital, T.; Azami, S.; Regan, J. C.; Funk, E.; Fröhlich, J.; Grönke, S.; Partridge, L.

10.1101/2022.04.20.488884 — physiology — Posted on 2022-04-21

1144 BiocMAP: A Bioconductor-friendly, GPU-Accelerated Pipeline for Bisulfite-Sequencing Data

Eagles, N. J.; Wilton, R.; Jaffe, A. E.; Torres, L. C.

10.1101/2022.04.20.488947 — bioinformatics — Posted on 2022-04-21

1145 Bacillus subtilis Biofilms in the Presence of Chlorhexidine - a Computational Approach to Morphology and Growth Kinetics Analysis

Gingichashvili, S.; Steinberg, D.; Sionov, R. V.; Feuerstein, O.; Cohen, N. E.

10.1101/2022.04.20.488818 — bioinformatics — Posted on 2022-04-21

1146 Scalable and model-free detection of spatial patterns and colocalization

Liu, Q.; Hsu, C.-Y.; Shyr, Y.

10.1101/2022.04.20.488961 — bioinformatics — Posted on 2022-04-21

1147 Fast, accurate antibody structure prediction from deep learning on massive set of natural antibodies

Ruffolo, J. A.; Chu, L.-S.; Mahajan, S. P.; Gray, J. J.

10.1101/2022.04.20.488972 — bioinformatics — Posted on 2022-04-21

1148 Persistent Memory as an Effective Alternative to Random Access Memory in Metagenome Assembly

Sun, J.; Egan, R.; Ho, H.; Li, Y.; Wang, Z.

10.1101/2022.04.20.488965 — bioinformatics — Posted on 2022-04-21

1149 Is single nucleus ATAC-seq accessibility a qualitative or quantitative measurement?

Miao, Z.; Kim, J.

10.1101/2022.04.20.488960 — bioinformatics — Posted on 2022-04-21

1150 Strategies for enriching and characterizing proteins with inhibitory properties on the yeast surface

Rezhdo, A.; Lessard, C. T.; Islam, M.; Van Deventer, J. A.

10.1101/2022.04.20.488975 — bioengineering — Posted on 2022-04-21

1151 Omics of an enigmatic marine amoeba uncovers unprecedented giant viruses gene trafficking and provides insights into its complex life cycle

Tekle, Y.; Tran, H.; Wang, F.; Udu, I.; Singla, M.

10.1101/2022.04.20.488852 — genomics — Posted on 2022-04-21

1152 Different conformations of EGF-induced receptor dimers involved in signaling and internalization

Haubrich, J.; Zwier, J. M.; Charrier-Savournin, F.; Prezeau, L.; Pin, J.-P.

10.1101/2022.04.19.488777 — molecular biology — Posted on 2022-04-21

1153 Lung spatial profiling reveals a T cell signature in COPD patients with fatal SARS-CoV-2 infection

Yang, C. X.; Tomchaney, M.; Landecho, M. F.; Recalde, B.; Oto, M. M.; Zulueta, J.; Malo, J.; Knoper, S.; Contoli, M.; Papi, A.; Vasilescu, D.; Sauler, M.; Straub, C.; Tan, C.; Martinez, F. D.; Bhattacharya, D.; Rosas, I.; Kheradmand, F.; Hackett, T. L.; Polverino, F.

10.1101/2022.04.20.488968 — immunology — Posted on 2022-04-21

1154 Statistical learning of distractor co-occurrences facilitates visual search

Thorat, S.; Quek, G.; Peelen, M. V.

10.1101/2022.04.20.488921 — neuroscience — Posted on 2022-04-21

1155 Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells

Zhu, Y.; Chew, K. Y.; Wu, M.; Karawita, A. C.; McCallum, G.; Steele, L. E.; Yamamoto, A.; Labzin, L. L.; Yarlagadda, T.; Khromykh, A. A.; Wang, X.; Sng, J.; Stocks, C. J.; Xia, Y.; Kollmann, T. R.; Martino, D.; Joensuu, M.; Meunier, F. A.; Balistreri, G.; Bielefeldt-Ohmann, H.; Bowen, A. C.; Kicic, A.; Sly, P. D.; Spann, K. M.; Short, K. R.

10.1101/2021.03.08.434300 — microbiology — Posted on 2022-04-21

1156 Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses using gene expression profiles of chemical and genetic perturbations

Shen, Z.; Halberg, A.; Fong, J. Y.; Guo, J.; Song, G.; Louie, B.; Luedtke, G. R.; Visuthikraisee, V.; Protter, A.; Koh, X.; Baik, T.; Lum, P. Y.

10.1101/2022.04.18.488682 — genomics — Posted on 2022-04-21

1157 Somatic mutation detection: a critical evaluation through simulations and reanalyses in oaks

Schmitt, S.; Leroy, T.; Heuertz, M.; Tysklind, N.

10.1101/2021.10.11.462798 — evolutionary biology — Posted on 2022-04-21

1158 Artificial selection methods from evolutionary computing show promise for directed evolution of microbes

Lalejini, A.; Dolson, E.; Vostinar, A. E.; Zaman, L.

10.1101/2022.04.01.486727 — evolutionary biology — Posted on 2022-04-21

1159 Habitat preference influences response to changing agricultural landscapes in two long-horned bees.

Hirayama, G. S.; Ushimaru, A.

10.1101/2022.04.15.488450 — ecology — Posted on 2022-04-21

1160 An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of P. aeruginosa

Koeppen, K.; Hampton, T.; Gerber, S.; Goo, Y. A.; Cho, B.-K.; Vermilyea, D.; Hogan, D.; Stanton, B.

10.1101/2022.04.19.488721 — microbiology — Posted on 2022-04-21

1161 Reciprocal feature encoding by corticalexcitatory and inhibitory neurons.

Duszkiewicz, A. J.; Skromne Carrasco, S.; Orhan, P.; Brown, E.; Owczarek, E.; Rojas Vite, G.; Wood, E. R.; Peyrache, A.

10.1101/2022.03.14.484357 — neuroscience — Posted on 2022-04-21

1162 A model for the intrinsic limit of cancer therapy: duality of treatment-induced cell death and treatment-induced stemness

Angelini, E.; Wang, Y.; Zhou, J. X.; Qian, H.; Huang, S.

10.1101/2021.10.05.463253 — cancer biology — Posted on 2022-04-21

1163 High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation

Laine, R. F.; Heil, H. S.; Coelho, S.; Nixon-Abell, J.; Jimenez, A.; Galgani, T.; Stubb, A.; Follain, G.; Culley, S.; Jacquemet, G.; Hajj, B.; Leterrier, C.; Henriques, R.

10.1101/2022.04.07.487490 — biophysics — Posted on 2022-04-21

1164 A Hybrid Method for Ultrasound-Based Tracking of Skeletal Muscle Architecture

Verheul, J.; Yeo, S.-H.

10.1101/2022.04.20.488774 — bioengineering — Posted on 2022-04-21

1165 A monogenean parasite reveals the widespread translocation of the African Clawed Frog in its native range

Schoeman, A. L.; du Preez, L. H.; Kmentova, N.; Vanhove, M. P. M.

10.1101/2021.10.21.465306 — ecology — Posted on 2022-04-21

1166 A Snapshot of the Global Drinking Water Virome: Diversity and Metabolic Potential Vary with Residual Disinfectant Use

Hegarty, B. E.; Dai, Z.; Raskin, L.; Pinto, A. J.; Wigginton, K.; Duhaime, M. B.

10.1101/2021.10.07.463401 — microbiology — Posted on 2022-04-21

1167 Eye movements reveal spatiotemporal dynamics of visually-informed planning in navigation

Zhu, S.; Lakshminarasimhan, K. J.; Arfaei, N.; Angelaki, D. E.

10.1101/2021.04.26.441482 — neuroscience — Posted on 2022-04-21

1168 p38 MAPK Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Virus Capsid Uncoating and Post-Uncoating Steps.

Shmulevitz, M.; Mohamed, A.

10.1101/2022.04.20.488989 — cell biology — Posted on 2022-04-21

1169 Replicative ageing perturbs the metabolic signature of murine C2C12 skeletal myotubes

Sadler, D. G.; Phelan, M. M.; Barlow, J.; Draijer:, R.; Jones, H.; Thijssen, D. H. J.; Stewart, C. E.

10.1101/2022.04.20.488970 — cell biology — Posted on 2022-04-21

1170 Ubiquitination occurs in the mitochondrial matrix byeclipsed targeted components of the ubiquitin machinery

Zhang, Y.; Karmon, O.; Das, K.; Mark, M.; Lehming, N.; Pines, O.

10.1101/2022.04.21.488890 — cell biology — Posted on 2022-04-21

1171 An anaphase switch in astral microtubule dynamics specifically requires the APC/C-Cdc20-dependent degradation of the mitotic cyclin Clb4

Zucca, F.; Li, J.; Visintin, C.; Gygi, S. P.; Visintin, R.

10.1101/2022.04.21.470331 — cell biology — Posted on 2022-04-21

1172 Phylogenomic evidence for the Origin of Obligately Anaerobic Anammox Bacteria around the Great Oxidation Event

Liao, T.; Wang, S.; Stueeken, E. E.; Luo, H.

10.1101/2021.07.07.451387 — microbiology — Posted on 2022-04-21

1173 A tonic nicotinic brake controls spike timing in striatal spiny projection neurons

Matityahu, L.; Malgady, J.; Schirelman, M.; Johansson, Y.; Wilking, J.; Silberberg, G.; Goldberg, J. A.; Plotkin, J. L.

10.1101/2021.11.02.466870 — neuroscience — Posted on 2022-04-21

1174 Fast event-related mapping of population fingertip tuning properties in human sensorimotor cortex at 7T

Khalife, S.; Francis, S. T.; Schluppeck, D.; Sanchez-Panchuelo, R.-M.; Besle, J.

10.1101/2022.01.06.471906 — neuroscience — Posted on 2022-04-21

1175 Locally adaptive temperature response of vegetative growth in Arabidopsis thaliana

Clauw, P.; Kerdaffrec, E.; Gunis, J.; Reichardt, I.; Nizhynska, V.; Koemeda, S.; Jez, J.; Nordborg, M.

10.1101/2022.02.15.480488 — plant biology — Posted on 2022-04-21

1176 A Hybrid Method for Ultrasound-Based Tracking of Skeletal Muscle Architecture

Verheul, J.; Yeo, S.-H.

10.1101/2022.04.20.488774 — bioengineering — Posted on 2022-04-21

1177 In situ polyadenylation enables spatial mapping of the total transcriptome

McKellar, D. W.; Mantri, M.; Hinchman, M.; Parker, J. S. L.; Sethupathy, P.; Cosgrove, B. D.; De Vlaminck, I.

10.1101/2022.04.20.488964 — genomics — Posted on 2022-04-21

1178 Capped nascent RNA sequencing reveals novel therapy-responsive enhancers in prostate cancer

Cotter, K. A.; Shah, S. R.; Paramo, M. I.; Lou, S.; Yao, L.; Rubin, P. D.; Chen, Y.; Gerstein, M.; Rubin, M.; Yu, H.

10.1101/2022.04.08.487666 — genomics — Posted on 2022-04-21

1179 iTRVZ: liquid nano-platform for signal integration on the plasma membrane

Tsunoyama, T. A.; Hoffmann, C.; Tang, B.; Hirosawa, K. M.; Nemoto, Y. L.; Kasai, R. S.; Fujiwara, T.; Suzuki, K. G.; Milovanovic, D.; Kusumi, A.

10.1101/2021.12.30.474523 — cell biology — Posted on 2022-04-21

1180 Multiple routes of adaptation to high levels of CIN and aneuploidy in budding yeast

Clarke, M. N.; Marsoner, T.; Alonso Y Adell, M.; Ravichandran, M. C.; Campbell, C. S.

10.1101/2022.04.21.489003 — cell biology — Posted on 2022-04-21

1181 The BAF A12T mutation associated with premature aging impedes lamin A/C recruitment to sites of nuclear rupture, contributing to nuclear envelope fragility.

Janssen, A. F. J.; Marcelot, A.; Breusegem, S. Y.; Legrand, P.; Zinn-Justin, S.; Larrieu, D.

10.1101/2022.02.25.481780 — cell biology — Posted on 2022-04-21

1182 BubR1 recruitment to the kinetochore via Bub1 enhances Spindle Assembly Checkpoint signaling

Banerjee, A.; Chen, C.; Humphrey, L.; Tyson, J. J.; Joglekar, A.

10.1101/2021.08.12.456107 — cell biology — Posted on 2022-04-21

1183 SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

Shih, A. Z. L.; Chen, Y.-C.; Verchere, C. B.; Willnow, T.

10.1101/2022.04.21.488729 — cell biology — Posted on 2022-04-21

1184 Adaptive plasticity in the healthy reading network investigated through combined neurostimulation and neuroimaging

Turker, S.; Kuhnke, P.; Schmid, F. R.; Cheung, V. K. M.; Zeidler, B.; Seidel, K.; Eckert, L.; Hartwigsen, G.

10.1101/2022.04.20.488885 — neuroscience — Posted on 2022-04-21

1185 Vision-dependent and -independent molecular maturation of mouse retinal ganglion cells

Whitney, I. E.; Butrus, S.; Dyer, M. A.; Rieke, F.; Sanes, J. R.; Shekhar, K.

10.1101/2022.04.20.488897 — neuroscience — Posted on 2022-04-21

1186 Making Biomedical Research Software FAIR: Actionable Step-by-step Guidelines with a User-support Tool

Patel, B.; Soundarajan, S.; Hu, Z.

10.1101/2022.04.18.488694 — scientific communication and education — Posted on 2022-04-21

1187 Associations between physical activity and cognitive dysfunction in older companion dogs: Results from the Dog Aging Project

Bray, E. E.; Raichlen, D. A.; Forsyth, K. K.; Promislow, D. E.; Alexander, G. E.; MacLean, E. L.; Dog Aging Project Consortium,

10.1101/2022.04.20.488879 — animal behavior and cognition — Posted on 2022-04-21

1188 'Ripple effects' of urban environmental characteristics on cognitive processes in Eurasian red squirrels.

Chow, P. K. Y.; Uchida, K.; Koizumi, I.

10.1101/2022.04.20.488863 — animal behavior and cognition — Posted on 2022-04-21

1189 Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

Flowers, S. E.; Kothari, R.; Torres Cleuren, Y. N.; Alcorn, M. R.; Ewe, C. K.; Alok, G.; Joshi, P. M.; Rothman, J. H.

10.1101/2021.10.27.466108 — genetics — Posted on 2022-04-21

1190 Dynamic molecular evolution of a supergene with suppressed recombination in white-throated sparrows

Jeong, H.; Baran, N. M.; Sun, D.; Chatterjee, P.; Layman, T. S.; Balakrishnan, C. M.; Maney, D. L.; Yi, S. V.

10.1101/2022.02.28.481145 — evolutionary biology — Posted on 2022-04-21

1191 Importance of Mobile Genetic Element Immunity in Numerically Abundant Trichodesmium Clades

Webb, E. A.; Held, N.; Zhao, Y.; Graham, E.; Conover, A. E.; Semones, J.; Lee, M. D.; Feng, Y.; Saito, M. A.; Hutchins, D. A.

10.1101/2022.04.20.488952 — microbiology — Posted on 2022-04-21

1192 How grower decision-making is modelled impacts the effect of plant disease control.

Murray-Watson, R. E.; Hamelin, F. M.; Cunniffe, N. J.

10.1101/2021.12.09.471899 — ecology — Posted on 2022-04-21

1193 Global and gene-specific translational regulation in Escherichia coli across different conditions

Zhang, D.; Li, S. H.-J.; King, C. G.; Wingreen, N. S.; Gitai, Z.; Li, Z.

10.1101/2022.04.19.488838 — genomics — Posted on 2022-04-21

1194 A new in vitro checkerboard-parasite reduction ratio interaction assay for early de-risk of clinical development of antimalarial combinations

Demarta-Gatsi, C.; Wicha, S.; Walz, A.; Cherkaoui-Rbati, M. H.; Gumpp, C.; Gobeau, N.; Möhrle, J. J.; Rottmann, M.

10.1101/2022.04.19.488858 — microbiology — Posted on 2022-04-21

1195 Physiological and transcriptional profiling of surfactin exerted antifungal effect against Candida albicans

Jakab, A.; Kovacs, F.; Balla, N.; Toth, Z.; Ragyak, A.; Sajtos, Z.; Csillag, K.; Nagy-Köteles, C.; Nemes, D.; Pocsi, I.; Majoros, L.; Kovacs, A. T.; Kovacs, R.

10.1101/2022.04.19.488861 — microbiology — Posted on 2022-04-21

1196 Positive Selection and Heat-Response Transcriptomes Reveal Adaptive Features of the Brassicaceae Desert Model, Anastatica hierochuntica

Eshel, G.; Duppen, N.; Wang, G.; Oh, D.-H.; Kazachkova, Y.; Herzyk, P.; Amtmann, A.; Gordon, M.; Chalifa-Caspi, V.; Oscar, M. A.; Bar-David, S.; Marshall-Colon, A.; Dassanayake, M.; Barak, S.

10.1101/2021.05.23.445339 — plant biology — Posted on 2022-04-21

1197 Deep learning can predict multi-omic biomarkers from routine pathology images: A systematic large-scale study

Arslan, S.; Mehrotra, D.; Schmidt, J.; Geraldes, A.; Singhal, S.; Hense, J.; Li, X.; Bass, C.; Kather, J. N.; Raharja-Liu, P.

10.1101/2022.01.21.477189 — cancer biology — Posted on 2022-04-21

1198 AI for predicting chemical-effect associations at the chemical universe level - deepFPlearn

Schor, J.; Scheibe, P.; Berndt, M.; Busch, W.; Lai, C.; Hackermüller, J.

10.1101/2021.06.24.449697 — bioinformatics — Posted on 2022-04-21

1199 Fragment-based computational design of antibodies targeting structured epitopes

Aguilar Rangel, M.; Bedwell, A.; Costanzi, E.; Taylor, R.; Russo, R.; Bernardes, G. J.; Ricagno, S.; Frydman, J.; Vendruscolo, M.; Sormanni, P.

10.1101/2021.03.02.433360 — bioinformatics — Posted on 2022-04-21

1200 Co-radiation of Leptospira and Tenrecidae (Afrotheria) on Madagascar

Gomard, Y.; Goodman, S. M.; Soarimalala, V.; Turpin, M.; Lenclume, G.; Ah-Vane, M.; Golden, C. D.; Tortosa, P.

10.1101/2021.12.08.471753 — evolutionary biology — Posted on 2022-04-21

1201 Cell-free, methylated DNA in blood samples reveals tissue-specific, cellular damage from radiation treatment

Barefoot, M. E.; Loyfer, N.; Kiliti, A. J.; Schmidt, M. O.; Shabi-Porat, S.; Jain, S.; Roth, S. M.; McDeed, A. P.; Shahrour, N.; Ballew, E.; Lin, Y.-T.; Li, H.-H.; Mays, A. D.; Rudra, S.; Riegel, A. T.; Unger, K.; Kaplan, T.; Wellstein, A.

10.1101/2022.04.12.487966 — cancer biology — Posted on 2022-04-20

1202 Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes

Pendyala, M.; Woods, P. S.; Brubaker, D. K.; Blaber, E. A.; Schmidt, T. A.; Chan, D.

10.1101/2022.04.20.488903 — bioengineering — Posted on 2022-04-20

1203 Investigating the antioxidant effects of Aloe vera: Possible role in regulating lipid profile and liver function in high fat and fructose diet (HFFD) fed mice.

Abubakar, A. M.; Dibal, N. I.; Attah, M. O. O.; Chiroma, S. M.

10.1101/2022.04.20.488905 — biochemistry — Posted on 2022-04-20

1204 Probing the rules of cell coordination in live tissues by interpretable machine learning based on graph neural networks

Yamamoto, T.; Cockburn, K.; Greco, V.; Kawaguchi, K.

10.1101/2021.06.23.449559 — cell biology — Posted on 2022-04-20

1205 Evaluation of sex differences in laser-induced choroidal neovascularization severity, phenotype and disease progression

Pearsall, E.

10.1101/2022.04.20.488904 — cell biology — Posted on 2022-04-20

1206 Single-cell mapping of tumor heterogeneity in pediatric rhabdomyosarcoma reveals developmental signatures with therapeutic relevance

Danielli, S. G.; Porpiglia, E.; De Micheli, A. J.; Navarro, N.; Zellinger, M. J.; Bechtold, I.; Kisele, S.; Volken, L.; Marques, J. G.; Kasper, S.; Bode, P. K.; Henssen, A. G.; Gürgen, D.; Roma, J.; Bühlmann, P.; Blau, H. M.; Wachtel, M.; Schäfer, B. W.

10.1101/2022.04.20.487706 — cancer biology — Posted on 2022-04-20

1207 Chromosome-level genome assembly for the Aldabra giant tortoise enables insights into the genetic health of a threatened population

Cilingir, F. G.; A'Bear, L.; Hansen, D.; Davis, L. R.; Bunbury, N.; Ozgul, A.; Croll, D.; Grossen, C.

10.1101/2022.04.20.488802 — genomics — Posted on 2022-04-20

1208 JiangShi: a widely distributed Mucin-like protein essential for Drosophila development

Huang, Y.; Li, L.; Rong, Y.

10.1101/2022.04.20.488880 — developmental biology — Posted on 2022-04-20

1209 The association of ubiquitin-associated protein 2-like and Ras-GTP-activating protein SH3 domain binding protein 1 mediated by small nucleolar RNA is essential for stress granule formation

Asano-Inami, E.; Yokoi, A.; Sugiyama, M.; Hyodo, T.; Hamaguchi, T.; Kajiyama, H.

10.1101/2022.04.20.488692 — cell biology — Posted on 2022-04-20

1210 Vegetation formation in Staphylococcus aureus endocarditis inversely correlates with RNAIII and sarA expression in invasive clonal complex 5 (CC5) isolates

Kinney, K. J.; Stach, J. M.; Kulhankova, K.; Brown, M.; Salgado-Pabon, W.

10.1101/2022.04.20.488955 — microbiology — Posted on 2022-04-20

1211 A remarkable expansion of oligopeptide transporter genes in rust fungi (Pucciniales) suggests a specialization in nutrients acquisition for obligate biotrophy

Guerillot, P.; Salamov, A.; Louet, C.; Morin, E.; Frey, P.; Grigoriev, I. V.; Duplessis, S.

10.1101/2022.04.20.488971 — microbiology — Posted on 2022-04-20

1212 Phylogenetic and phenotypic analysis of five subgroups of Ralstonia solanacearum phylotype IIB sequevar 4 reveals that the "not pathogenic to banana (NPB)" ecotype is polyphyletic.

Beutler, J.; Holden, S.; Georgoulis, S. J.; Williams, D.; Norman, D. J.; Lowe-Power, T. M.

10.1101/2022.04.20.488689 — microbiology — Posted on 2022-04-20

1213 lsaBGC provides a comprehensive framework for evolutionary analysis of biosynthetic gene clusters within focal taxa

Salamzade, R.; Cheong, J. Z. A.; Sandstrom, S.; Swaney, M. H.; Starr, N. L.; Singh, A. M.; Kalan, L.

10.1101/2022.04.20.488953 — microbiology — Posted on 2022-04-20

1214 Macrophages undergo necroptosis during severe influenza A infection and contribute to virus-associated cytokine storm

Ferreira, A. C.; Sacramento, C. Q.; Pereira-Dutra, F. S.; Fintelman-Rodrigues, N.; Silva, P. P.; Mattos, M.; de Freitas, C. S.; Marttorelli, A.; de Melo, G. R.; Macedo, M. C.; Azevedo-Quintanilha, I. G.; Carlos, A. S.; Emidio, J. V.; Garcia, C. C.; Bozza, P. T.; Bozza, F. A.; Souza, T. M. L.

10.1101/2022.04.20.488871 — immunology — Posted on 2022-04-20

1215 Myeloid-Derived Suppressor Cells are relevant factors to predict the severity of multiple sclerosis

Ortega, M. C.; Lebron-Galan, R.; Machin-Diaz, I.; Naughton, M.; Perez-Molina, I.; Garcia-Arocha, J.; Garcia-Dominguez, J. M.; Goicoechea-Briceno, H.; Vila-del Sol, V.; Quintanero-Casero, V.; Garcia-Montero, R.; Galan, V.; Camacho-Toledano, C.; Martinez-Gines, M. L.; Fitzgerald, D.; Clemente, D.

10.1101/2022.04.20.488896 — neuroscience — Posted on 2022-04-20

1216 Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression

Milosevic, A.; Medrihan, L.; Knudsens, M.; Ferraro, T.; Vasques, P. D. C.; Romin, Y.; Fujisawa, S.; Greengard, P.

10.1101/2022.04.20.488950 — neuroscience — Posted on 2022-04-20

1217 Vision-dependent and -independent molecular maturation of mouse retinal ganglion cells

Whitney, I.; Butrus, S.; Dyer, M. A.; Rieke, F.; Sanes, J.; Shekhar, K.

10.1101/2022.04.20.488897 — neuroscience — Posted on 2022-04-20

1218 Comprehensive multi-omics single-cell data integration reveals greater heterogeneity in the human immune system

Xu, C.; Yang, J.; Kosters, A.; Babcock, B. R.; Qiu, P.; Ghosn, E.

10.1101/2021.07.25.453651 — systems biology — Posted on 2022-04-20

1219 Spatiotemporal Profiling of Seed-Associated Microbes of an Aquatic, Intermediate Recalcitrant Species, Zizania palustris L. and the Impact of Anti-Microbial Seed Treatments

Gietzel, C.; McGilp, L.; Kimball, J.

10.1101/2022.04.20.488936 — plant biology — Posted on 2022-04-20

1220 Hybridization In The Late Pleistocene: Merging Morphological And Genetic Evidence

Harvati, K.; Ackerman, R. R.

10.1101/2022.04.20.488874 — paleontology — Posted on 2022-04-20

1221 G6PD Inhibition Sensitizes Ovarian Cancer Cells to Oxidative Stress in the Metastatic Omental Microenvironment

Bose, S.; Huang, Q.; Ma, Y.; Wang, L.; Rivera, G. O.; Ouyang, Y.; Whitaker, R.; Gibson, R. A.; Kontos, C. D.; Berchuck, A.; Previs, R.; Shen, X.

10.1101/2022.04.20.488962 — cancer biology — Posted on 2022-04-20

1222 A benchmark of Hi-C scaffolders using reference genomes and de novo assemblies

Sur, A.; Noble, W. S.; Myler, P. J.

10.1101/2022.04.20.488415 — genomics — Posted on 2022-04-20

1223 Src42A is required for E-cadherin dynamics at cell junctions during Drosophila axis elongation

Chandran, L.; Backer, W.; Beati, H.; Kong, D.; Luschnig, S.; Muller, H.-A. J.

10.1101/2022.04.20.488907 — developmental biology — Posted on 2022-04-20

1224 Matrix stiffness regulates Notch signaling activity in endothelial cells

Kretschmer, M.; Mamistvalov, R.; Sprinzak, D.; Vollmar, A. M.; Zahler, S.

10.1101/2022.04.20.488899 — cell biology — Posted on 2022-04-20

1225 Uncovering the structural flexibility of SARS-CoV-2 glycoprotein spike variants

Arruda, H. R. S.; Lima, T. M.; Alvim, R. G. F.; Victorio, F. B. A.; Abreu, D. P. B.; Marsili, F. F.; Cruz, K. D.; Sosa-Acosta, P.; Quinones-Vega, M.; Guedes, J. S.; Nogueira, F. C. S.; Silva, J. L.; Castilho, L. R.; de Oliveira, G. A. P.

10.1101/2022.04.20.488873 — biochemistry — Posted on 2022-04-20

1226 Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease

Crouch, D. J. M.; Inshaw, J. R. J.; Robertson, C. C.; Zhang, J.-Y.; Chen, W.-M.; Onengut-Gumuscu, S.; Cutler, A. J.; Sidore, C.; Cucca, F.; Pociot, F.; Concannon, P.; Rich, S. S.; Todd, J. A.

10.1101/2021.02.05.429962 — genetics — Posted on 2022-04-20

1227 A perspective on information optimality in a neural circuit

Friedman, R.

10.1101/2021.10.27.466179 — neuroscience — Posted on 2022-04-20

1228 Distinct ground state and activated state modes of spiking in forebrain neurons

Levenstein, D.; Gornet, J.; Huszar, R.; Girardeau, G.; Grosmark, A.; Peyrache, A.; Senzai, Y.; Watson, B.; Rinzel, J.; Buzsaki, G.

10.1101/2021.09.20.461152 — neuroscience — Posted on 2022-04-20

1229 Allele mining, evolutionary genetic analysis of TaHKT1;5 gene and evaluation of salinity stress in selected lines of wheat.

Thiyagarajan, K.; Mathur, P. N.; Vikram, P.; Sehgal, D.; Valluru, R.; Govindan, V.; Rahman, H.; Thapa, D. B.; Pantha, S.; Galeffi, P.; Latini, A.; Cantale, C.; Porceddu, E.; Joshi, A. K.

10.1101/2022.04.01.486792 — genetics — Posted on 2022-04-20

1230 Emergence of new subgenomic mRNAs in SARS-CoV-2

Mears, H. V.; Young, G. R.; Sanderson, T.; Harvey, R.; Crawford, M.; Snell, D. M.; Fowler, A. S.; Hussain, S.; Nicod, J.; Peacock, T. P.; Emmott, E.; Finsterbusch, K.; Luptak, J.; Wall, E.; Williams, B.; Gandhi, S.; Swanton, C.; Bauer, D. L.

10.1101/2022.04.20.488895 — microbiology — Posted on 2022-04-20

1231 Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic

Blaurock, C.; Breithaupt, A.; Weber, S.; Wylezich, C.; Keller, M.; Mohl, B.-P.; Goerlich, D.; Groschup, M. H.; Sadeghi, B.; Hoeper, D.; Mettenleiter, T. C.; Balkema-Buschmann, A.

10.1101/2022.04.19.488826 — microbiology — Posted on 2022-04-20

1232 Low-dose bivalent mRNA vaccine is highly effective against different SARS-CoV-2 variants in a transgenic mouse model

Corleis, B.; Hoffmann, D.; Rauch, S.; Fricke, C.; Roth, N.; Gergen, J.; Kovacikova, K.; Schlottau, K.; Halwe, N. J.; Ulrich, L.; Schön, J.; Wernike, K.; Widera, M.; Ciesek, S.; Mueller, S. O.; Mettenleiter, T. C.; Petsch, B.; Beer, M.; Dorhoi, A.

10.1101/2022.04.20.485440 — immunology — Posted on 2022-04-20

1233 Broadly neutralizing antibodies against Omicron variants of SARS-CoV-2 derived from mRNA-lipid nanoparticle-immunized mice

Lu, R.-M.; Liang, K.-H.; Chiang, H.-L.; Hsu, F.-F.; Lin, H.-T.; Chen, W.-Y.; Ke, F.-Y.; Kumari, M.; Chou, Y.-C.; Wu, H.-C.

10.1101/2022.04.19.488843 — immunology — Posted on 2022-04-20

1234 Geometry of spiking activity in early visual cortex: a Topological Data Analytic approach

Guidolin, A.; Desroches, M.; Victor, J. D.; Purpura, K. P.; Rodrigues, S.

10.1101/2022.03.16.484568 — neuroscience — Posted on 2022-04-20

1235 The Psychometrics of Automatic Speech Recognition

Weerts, L.; Rosen, S.; Clopath, C.; Goodman, D. F. M.

10.1101/2021.04.19.440438 — neuroscience — Posted on 2022-04-20

1236 Skeletal Muscle Proteostasis Promotes Central Nervous System Rejuvenation and Reduces Neuroinflammation during Aging and Neurodegenerative Disease

Matthews, I.; Birnbaum, A.; Gromova, A.; Coutinho, K.; McGraw, M.; Patterson, D.; Banks, M. T.; Nobles, A.; Nguyen, N.; Miranda, H. C.; La Spada, A. R.; Cortes, C. J.

10.1101/2022.03.07.482891 — neuroscience — Posted on 2022-04-20

1237 Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data

Li, S.; Schmid, K. T.; de Vries, D.; Korshevniuk, M.; Oelen, R.; van Blokland, I.; BIOS Consortium, ; sc-eQTLgen Consortium, ; Groot, H. E.; Swertz, M. A.; van der Harst, P.; Westra, H.-J.; van der Wijst, M.; Heinig, M.; Franke, L.

10.1101/2022.04.20.488925 — genetics — Posted on 2022-04-20

1238 Sufu regulation of Hedgehog signaling in P19 cells is required for proper astrocyte differentiation

Spice, D. M.; Dierolf, J.; Kelly, G. M.

10.1101/2021.08.24.457497 — developmental biology — Posted on 2022-04-20

1239 Multistage and transmission-blocking tubulin targeting potent antimalarial discovered from the open access MMV Pathogen Box

Kumari, G.; Jain, R.; Sah, R. K.; Kalia, I.; Vashistha, M.; Singh, P.; Singh, A. P.; Samby, K.; Burrows, J.; singh, s.

10.1101/2022.04.20.488926 — microbiology — Posted on 2022-04-20

1240 Distinct representation of cue-outcome association by D1 and D2 neurons in the ventral striatum's olfactory tubercle

Martiros, N.; Kapoor, V.; Kim, S. E.; Murthy, V. N.

10.1101/2021.11.01.466363 — neuroscience — Posted on 2022-04-20

1241 Brain-wide neuronal activation and functional connectivity are modulated by prior exposure to repetitive learning episodes.

Terstege, D. J.; Durante, I. M.; Epp, J. R.

10.1101/2021.03.28.437394 — neuroscience — Posted on 2022-04-20

1242 Supercoiling-mediated feedback rapidly couples and tunes transcription

Johnstone, C. P.; Galloway, K. E.

10.1101/2022.04.20.488937 — synthetic biology — Posted on 2022-04-20

1243 Low Level Whole-Brain Radiation Enhances Theranostic Potential Of Single Domain Antibody Fragments For HER2-Positive Brain Metastases

Procissi, D.; Jannetti, S.; Zannikou, M.; Zhou, Z.; McDougald, D.; Kanojia, D.; Vaidyanathan, G.; Zalutsky, M. R.; Balyasnikova, I. V.

10.1101/2022.04.19.488555 — cancer biology — Posted on 2022-04-20

1244 An Integrated Platform for High-Throughput Nanoscopy

Barentine, A. E. S.; Lin, Y.; Courvan, E. M.; Kidd, P.; Liu, M.; Balduf, L.; Phan, T.; Rivera-Molina, F.; Grace, M. R.; Marin, Z.; Lessard, M.; Rios-Chen, J.; Wang, S.; Neugebauer, K. M.; Bewersdorf, J.; Baddeley, D.

10.1101/606954 — biophysics — Posted on 2022-04-20

1245 Protein-Protein Interaction Site Prediction Based on Attention Mechanism and Convolutional Neural Networks

Lu, S.; Li, Y.; Ma, Q.; Nan, X.; Zhang, S.

10.1101/2021.07.10.451856 — bioinformatics — Posted on 2022-04-20

1246 Drug screening at single-organoid resolution via bioprinting and interferometry

Tebon, P. J.; Wang, B.; Markowitz, A. L.; Davarifar, A.; Krawczuk, P.; Murray, G.; Nguyen, H. T. L.; Tavanaie, N.; Nguyen, T. L.; Boutros, P. C.; Teitell, M. A.; Soragni, A.

10.1101/2021.10.03.462896 — bioengineering — Posted on 2022-04-20

1247 Targeting SARS-CoV-2 infection through CAR-T like bispecific T cell engagers incorporating ACE2

Dogan, M.; Kozhaya, L.; Placek, L.; Karabacak, F.; Yigit, M.; Unutmaz, D.

10.1101/2022.01.19.476940 — bioengineering — Posted on 2022-04-20

1248 TAF4b Transcriptional Regulation During Cellular Quiescence of Developing Prospermatogonia

Gura, M.; Bartholomew, M.; Abt, K.; Relovska, S.; Kimberly, S.; Freiman, R. N.

10.1101/2022.04.20.488869 — genetics — Posted on 2022-04-20

1249 Speciation without gene-flow in hybridizing deer

Kessler, C.; Shafer, A.; Wootton, E.

10.1101/2022.04.20.488928 — evolutionary biology — Posted on 2022-04-20

1250 Environmental DNA persistence and fish detection in captive sponges

Cai, W.; Harper, L. R.; Neave, E.; Shum, P.; Craggs, J.; Arias, M. B.; Riesgo, A.; Mariani, S.

10.1101/2022.04.20.488927 — ecology — Posted on 2022-04-20

1251 BIN2 phosphorylates the Thr280 of CO to restrict its function in promoting Arabidopsis flowering

Sun, J.; Ju, L.; Dong, H.; Yang, R.; Jing, Y.; Yang, Z.; Zhang, Y.; Zhu, Y.; Liu, L.; Chen, K.

10.1101/2022.04.20.488915 — molecular biology — Posted on 2022-04-20

1252 The structure and evolutionary diversity of the fungal E3-binding protein

Forsberg, B.

10.1101/2022.04.20.488913 — molecular biology — Posted on 2022-04-20

1253 Gut microbiota analysis of the western honeybee (Apis mellifera L.) infested with the mite Varroa destructor reveals altered bacterial and archaeal community

Kim, M.; Kim, W. J.; Park, S.-J.

10.1101/2022.04.20.488909 — microbiology — Posted on 2022-04-20

1254 Functional Specialization of Parallel Distributed Networks Revealed by Analysis of Trial-to-Trial Variation in Processing Demands

DiNicola, L. M.; Ariyo, O. I.; Buckner, R. L.

10.1101/2022.04.20.488923 — neuroscience — Posted on 2022-04-20

1255 Two interdigitated fine-scale channels for encoding motion and stereopsis within the human magnocellular stream

Kennedy, B.; Bex, P.; Hunter, D. G.; Nasr, S.

10.1101/2022.04.20.488911 — neuroscience — Posted on 2022-04-20

1256 Release of VAMP5-positive extracellular vesicles from specialized domains of retinal Müller cells in vivo

Demais, V.; Pohl, A. M.; Wunderlich, K. A.; Pfaller, A. M.; Kaplan, L.; Barthelemy, A.; Dittrich, R.; Puig, B.; Giebel, B.; Hauck, S. M.; Pfrieger, F. W.; Grosche, A.

10.1101/2022.04.20.488918 — neuroscience — Posted on 2022-04-20

1257 Action at a distance: Defects in division plane positioning in the root meristematic zone affect cell organization in the differentiation zone

Mills, A. M.; Rasmussen, C.

10.1101/2021.04.30.442137 — plant biology — Posted on 2022-04-20

1258 bulkAnalyseR: An accessible, interactive pipeline for analysing and sharing bulk multi-modal sequencing data

Moutsopoulos, I.; Williams, E. C.; Mohorianu, I.

10.1101/2021.12.23.473982 — bioinformatics — Posted on 2022-04-20

1259 Genomic profiling of climate adaptation in Aedes aegypti along an altitudinal gradient in Nepal indicates non-gradual expansion of the disease vector

Kramer, I. M.; Pfenninger, M.; Feldmeyer, B.; Dhimal, M.; Gautam, I.; Shreshta, P.; Baral, S.; Phuyal, P.; Hartke, J.; Magdeburg, A.; Groneberg, D. A.; Ahrens, B.; Mueller, R.; Waldvogel, A.-M.

10.1101/2022.04.20.488929 — genomics — Posted on 2022-04-20

1260 Insights into bear evolution from a Pleistocene polar bear genome

Lan, T.; Leppala, K.; Tomlin, C.; Talbot, S. L.; Sage, G. K.; Farley, S.; Shideler, R. T.; Bachmann, L.; Wiig, O.; Albert, V. A.; Salojarvi, J.; Mailund, T.; Drautz-Moses, D. I.; Schuster, S. C.; Herrera-Estrella, L.; Lindqvist, C.

10.1101/2021.12.11.472228 — evolutionary biology — Posted on 2022-04-20

1261 Extreme Heterogeneity in Genomic Differentiation between Phenotypically Divergent Songbirds: A Test of Mitonuclear Co-introgression

Nikelski, E.; Rubtsov, A. S.; Irwin, D.

10.1101/2021.08.08.455564 — evolutionary biology — Posted on 2022-04-20

1262 The "Alu-ome" shapes the epigenetic environment of regulatory elements controlling cellular defense

Costallat, M.; Batsche, E.; Rachez, C.; Muchardt, C.

10.1101/2021.11.21.469436 — molecular biology — Posted on 2022-04-20

1263 First detection of Leptospira santarosai in the reproductive track of a boar: a potential threat to swine production and public health

Diaz, E. A.; Luna, L.; Burgos-Mayorga, A.; Donoso, G.; Guzman, D.; Baquero, M. I.; Pearson, T.; Barragan, V. A.

10.1101/2022.04.20.488867 — microbiology — Posted on 2022-04-20

1264 Listeria monocytogenes Infection Alters Extracellular Vesicles Produced by Trophoblast Stem Cells to Confer a Pro-Inflammatory State

Kaletka, J.; Lee, K. H.; Kanada, M.; Hardy, J.

10.1101/2022.04.19.488859 — immunology — Posted on 2022-04-20

1265 A neurocomputational theory of action regulation predicts motor behavior in neurotypical individuals and patients with Parkinsons disease

Zhong, S.; Choi, J.; Hashoush, N. G.; Babayan, D.; Malekmohammad, M.; Pouratian, N.; Christopoulos, V.

10.1101/2022.04.20.488864 — neuroscience — Posted on 2022-04-20

1266 Temporal dynamics of competition between statistical learning and episodic memory in intracranial recordings of human visual cortex

Sherman, B. E.; Graves, K. N.; Huberdeau, D. M.; Quraishi, I. H.; Damisah, E. C.; Turk-Browne, N. B.

10.1101/2022.03.14.484293 — neuroscience — Posted on 2022-04-20

1267 helixCAM: A Platform for Programmable Cellular Assembly in Bacteria and Human Cells

Chao, G.; Wannier, T. M.; Travis, C.; Borders, N. C.; Appleton, E.; Chadha, A.; Lebar, T.; Church, G. M.

10.1101/2022.04.19.488034 — synthetic biology — Posted on 2022-04-20

1268 Genomic regions associate with major axes of variation driven by gas exchange and leaf construction traits in cultivated sunflower (Helianthus annuus L.)

Earley, A. M.; Temme, A. A.; Cotter, C. R.; Burke, J. M.

10.1101/2022.04.01.486477 — plant biology — Posted on 2022-04-20

1269 scAEGAN: Unification of Single-Cell Genomics Data by Adversarial Learning of Latent Space Correspondences

Khan, S. A.; Lehmann, R.; Martinez-de-Morentin, X.; Maillo Ruiz, A.; Lagani, V.; Kiani, N. A.; Cabrero, D. G.; Tegner, J.

10.1101/2022.04.19.488745 — bioinformatics — Posted on 2022-04-20

1270 From motif to function:Inferring the functions of long zinc finger proteins through combinatorial selection

Zuo, Z.

10.1101/2022.04.19.488842 — bioinformatics — Posted on 2022-04-20

1271 High resolution shotgun metagenomics: the more data, the better?

Tremblay, J.; Greer, C. W.

10.1101/2022.04.19.488797 — bioinformatics — Posted on 2022-04-20

1272 A robust and transformation-free joint model with matching and regularization for metagenomic trajectory and disease onset

Li, Q.; Vehik, K.; Li, C.; Triplett, E. W.; Roesch, L.; Hu, Y.-J.; Krischer, J. P.

10.1101/2022.04.19.488854 — bioinformatics — Posted on 2022-04-20

1273 Spatial and social structure of rewilded laboratory mice

Vogt, C. C.; Zipple, M. N.; Sprockett, D. D.; Miller, C. H.; Hardy, S. X.; Arthur, M. K.; Greenstein, A. M.; Colvin, M. S.; Moeller, A. H.; Sheehan, M. J.

10.1101/2022.04.19.488643 — animal behavior and cognition — Posted on 2022-04-20

1274 Evolution of influenza A virus hemagglutinin H1 and H3 across host species

Trovao, N. S.; Khan, S. M.; Lemey, P.; Nelson, M. I.; Cherry, J. L.

10.1101/2022.04.20.488870 — evolutionary biology — Posted on 2022-04-20

1275 Hidden Talents: Silent Gene Clusters Encoding Magnetic Organelle Biosynthesis in a Non-Magnetotactic Phototrophic Bacterium

Dziuba, M. V.; Paulus, A.; Schramm, L.; Awal, R. P.; Posfai, M.; Monteil, C.; Fouteau, S.; Uebe, R.; Schueler, D.

10.1101/2022.04.19.488322 — microbiology — Posted on 2022-04-20

1276 An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of P. aeruginosa

Koeppen, K.; Hampton, T.; Gerber, S.; Goo, Y. A.; Cho, B.-K.; Vermilyea, D.; Hogan, D.; Stanton, B.

10.1101/2022.04.19.488721 — microbiology — Posted on 2022-04-20

1277 Activation of IP10/CXCR3 signaling with highly coincidental with PrPSc deposit in the brains of scrapie infected mice

jia, C.; Chen, c.; chao, H.; wei, Y.; lin, W.; dong, C. d.; zhang, W. y.; qi, S.; ping, D. x.

10.1101/2022.04.19.488860 — neuroscience — Posted on 2022-04-20

1278 Transmission of Cervid Prions to Humanized Mice Demonstrates the Zoonotic Potential of CWD

Hannaoui, S.; Zemlyankina, I.; Chang, S. C.; Arifin, M. I.; Beringue, V.; McKEnzie, D.; Schatzl, H. M.; Gilch, S.

10.1101/2022.04.19.488833 — neuroscience — Posted on 2022-04-20

1279 Chaotic dynamics in spatially distributed neuronal networks generate population-wide shared variability

Mosheiff, N.; Ermentrout, B.; Huang, C.

10.1101/2022.04.19.488846 — neuroscience — Posted on 2022-04-20

1280 Autophagy and evasion of immune system by SARS-CoV-2. Structural features of the Non-structural protein 6 from Wild Type and Omicron viral strains interacting with a model lipid bilayer.

Bignon, E.; Marazzi, M.; Grandemange, S.; Monari, A.

10.1101/2022.01.05.475107 — biophysics — Posted on 2022-04-20

1281 moRphology - dEep Learning Imaging Cells (RELIC) - to Differentiate Between Normal and Pathological Kidney Exfoliated Cells

Habibalahi, A.; Campbell, J.; Mahbub, S.; Anwer, A.; Nguyen, L.; Gill, A.; Wong, M.; chou, A.; Pollock, C.; Saad, S.; Goldys, E.

10.1101/2022.04.19.488847 — bioinformatics — Posted on 2022-04-20

1282 Commercial ChIP-Seq library preparation kits performed differently for different classes of protein targets

Simper, M. S.; Coletta, L. D.; Gaddis, S.; Lin, K.; Mikulec, C. D.; Takata, Y.; Tomida, M. W.; Zhang, D.; Tang, D. G.; Estecio, M. R.; Shen, J.; Lu, Y.

10.1101/2022.04.19.488832 — bioinformatics — Posted on 2022-04-20

1283 Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure

Lee, D.; Han, S. K.; Yaacov, O.; Berk-Rauch, H.; Mathiyalagan, P.; Ganesh, S. K.; Chakravarti, A.

10.1101/2022.04.19.488795 — genetics — Posted on 2022-04-20

1284 Evaluating drivers of spatiotemporal individual condition of a bottom-associated marine fish

Lindmark, M.; Anderson, S. C.; Gogina, M.; Casini, M.

10.1101/2022.04.19.488709 — ecology — Posted on 2022-04-20

1285 DNA metabarcoding reveals the threat of rapidly expanding barred owl populations to native wildlife in western North America

Kryshak, N. F.; Fountain, E. D.; Hofstadter, D. F.; Dotters, B. P.; Roberts, K. N.; Wood, C. M.; Kelly, K. G.; Papraniku, I. F.; Kulzer, P. J.; Wray, A. K.; Kramer, H. A.; Dumbacher, J. P.; Keane, J. J.; Shaklee, P. A.; Gutierrez, R. J.; Peery, M. Z.

10.1101/2022.04.19.488820 — ecology — Posted on 2022-04-20

1286 The Global Register of Introduced and Invasive Species: Country Compendium

McGeoch, M. A.; Pagad, S.; Bisset, S.; Genovesi, P.; Groom, Q.; Hirsch, T.; Jetz, W.; Ranipeta, A.; Schigel, D.; Sica, Y. V.

10.1101/2022.04.19.488841 — ecology — Posted on 2022-04-20

1287 TubULAR: Tracking deformations of dynamic tissues and interfaces in 3D

Mitchell, N. P.; Cislo, D. J.

10.1101/2022.04.19.488840 — developmental biology — Posted on 2022-04-20

1288 Prolonged dexamethasone exposure enhances zebrafish lateral-line regeneration but disrupts mitochondrial homeostasis and hair cell function

Saettele, A. L.; Wong, H.-t. C.; Kindt, K. S.; Warchol, M. E.; Sheets, L.

10.1101/2022.04.19.488823 — neuroscience — Posted on 2022-04-20

1289 Microglial inflammatory activation paradoxically improves glucose tolerance during diet-induced obesity

Douglass, J. D.; Valdearcos, M.; Ness, K. M.; Wyse-Jackson, A.; Dorfman, M. D.; Frey, J. M.; Niraula, A.; Banerjee, J.; Fasnacht, R.; Robblee, M.; Koliwad, S. K.; Thaler, J.

10.1101/2022.04.19.488819 — neuroscience — Posted on 2022-04-20

1290 Cortical facilitation of somatosensory inputs using gravity-related tactile information in patients with bilateral vestibular loss

Fabre, M.; Beullier, L.; Sutter, C.; Krebritchi, A.; Chavet, P.; Simoneau, M.; Toupet, M.; Blouin, J.; Mouchnino, L.

10.1101/2022.04.19.488449 — neuroscience — Posted on 2022-04-20

1291 Restriction of dietary fat, but not carbohydrate, alters brain reward circuitry in adults with obesity

Darcey, V. L.; Guo, J.; Courville, A.; Gallagher, I.; Avery, J. A.; Simmons, W. K.; Ingeholm, J. E.; Herscovitch, P.; Martin, A.; Hall, K. D.

10.1101/2022.04.19.488800 — neuroscience — Posted on 2022-04-20

1292 Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

Northey, J. J.; Yui, Y.; Hayward, M.-K.; Stashko, C.; Kai, F.; Mouw, J. K.; Thakar, D.; Lakins, J. N.; Ironside, A. J.; Samson, S.; Mukhtar, R. A.; Hwang, E. S.; Weaver, V. M.

10.1101/2022.04.19.487741 — cancer biology — Posted on 2022-04-20

1293 Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapies.

Lang, H.; Beraud, C.; Cabel, L.; Lassalle, M.; Fontugne, J.; Krucker, C.; Dufour, F.; Groeneveld, C. S.; Dixon, V.; Meng, X.; Kamoun, A.; Chapeaublanc, E.; De Reynies, A.; Game, X.; Rischmann, P.; Bieche, I.; Masliah-Planchon, J.; Beaurepere, R.; Allory, Y.; Lindner, V.; Misseri, Y.; Radvanyi, F.; lluel, P.; Bernard-Pierrot, I.; Massfelder, T.

10.1101/2022.04.19.488770 — cancer biology — Posted on 2022-04-20

1294 Lagrange-NG: The next generation of Lagrange

Bettisworth, B.; Smith, S. A.; Stamatakis, A.

10.1101/2022.04.19.488734 — bioinformatics — Posted on 2022-04-20

1295 Dynamics and Energetics of Bottlenose Dolphins (Tursiops truncatus) Fluke-and-Glide Gait

Zhang, D.; Wang, Y.; Gabaldon, J.; Lauderdale, L.; Miller, L.; Barton, K.; Shorter, K. A.

10.1101/2022.04.19.488827 — animal behavior and cognition — Posted on 2022-04-20

1296 The estrogen receptor α cistrome in human endometrium and epithelial organoids

Hewitt, S. C.; Wu, S.-P.; Wang, T.; Ray, M.; Brolinson, M.; Young, S. L.; Spencer, T. E.; DeCherney, A.; DeMayo, F. J.

10.1101/2022.04.19.488787 — genomics — Posted on 2022-04-20

1297 Functional characterization of putative ecdysone transporters in lepidopteran pests

Samantsidis, G.-R.; Fotiadou, M.; Tzavellas, S.; Geibel, S.; Nauen, R.; Swevers, L.; Denecke, S. M.; Vontas, J.

10.1101/2022.04.20.488866 — genetics — Posted on 2022-04-20

1298 pH as an eco-evolutionary driver of priority effects

Chappell, C. R.; Dhami, M. K.; Bitter, M. C.; Czech, L.; Paredes, S. H.; Eritano, K.; Golden, L.-A.; Hsu, V.; Kieschnick, C.; Rush, N.; Fukami, T.

10.1101/2022.04.19.487947 — ecology — Posted on 2022-04-20

1299 Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation

Yang, Y.; Brown, M. C.; Zhang, G.; Stevenson, K.; Mohme, M.; Kornahrens, R.; Bigner, D. D.; Ashley, D. M.; Lopez, G. Y.; Gromeier, M.

10.1101/2022.04.19.488771 — cancer biology — Posted on 2022-04-20

1300 Nanostructure of the desmosomal plaque

Iachina, I.; Gam-Hadberg, H.; Brewer, J. R.

10.1101/2022.04.18.488620 — cell biology — Posted on 2022-04-20

1301 SUMOylation controls the rapid transcriptional reprogramming induced by anthracyclines in Acute Myeloid Leukemias

Boulanger, M.; Kifagi, C.; Ristic, M.; Gabellier, L.; Tempe, D.; Sigurdsson, J.-O.; Kaoma, T.; Andrieu-Soler, C.; Forne, T.; Soler, E.; Hicheri, Y.; Gueret, E.; Vallar, L.; Olsen, J. V.; Cartron, G.; PIechaczyk, M.; Bossis, G.

10.1101/2022.04.19.488613 — molecular biology — Posted on 2022-04-20

1302 Statistical evaluation of metaproteomics and 16s rRNA amplicon sequencing techniques for the study of the gut microbiota establishment of infants with cystic fibrosis

Garcia-Duran, C.; Romeu, E.; Hernaez-Sanchez, M. L.; Maruri, A.; Baston-Paz, N.; Lamas, A.; Vicente, S.; Perez-Ruiz, E.; Delgado, I.; Luna-Paredes, C.; de Dios-Caballero, J.; Zamora, J.; Monteoliva, L.; Gil, C.; del Campo, R.

10.1101/2022.04.18.488713 — microbiology — Posted on 2022-04-20

1303 Generation of raptor diversity in Europe: linking speciation to climate changes and the ability to migrate

Negro Balmaseda, J. J.; Rodriguez-Rodriguez, E. J.; Rodriguez Martin, A.; Bildstein, K.

10.1101/2022.03.29.486263 — evolutionary biology — Posted on 2022-04-20

1304 IZUMO1 is a sperm fusogen

Brukman, N. G.; Nakajima, K. P.; Valansi, C.; Flyak, K.; Li, X.; Higashiyama, T.; Podbilewicz, B.

10.1101/2022.02.01.478669 — cell biology — Posted on 2022-04-20

1305 Photoprotection is regulated by light-independent CO2 availability

Ruiz-Sola, M. A.; Flori, S.; Yuan, Y.; Villain, G.; Sanz-Luque, E.; Redekop, P.; Tokutsu, R.; Küken, A.; Tsichla, A.; Kepesidis, G.; Allorent, G.; Arend, M.; Iacono, F.; Finazzi, G.; Hippler, M.; Nikoloski, Z.; Minagawa, J.; Grossman, A. R.; Petroutsos, D.

10.1101/2021.10.23.465040 — plant biology — Posted on 2022-04-20

1306 mTORC1 activity is essential for disease progression in chronic lymphocytic leukemia

Malik, N.; Hay, J.; Dunn, K. M.; Nakagawa, R.; Sansom, O. J.; Michie, A. M.

10.1101/2022.04.19.488778 — cancer biology — Posted on 2022-04-20

1307 A genotoxic antibody drug conjugate targeting CD276/B7H3 demonstrates efficacy across multiple biomarker defined classes of treatment refractory metastatic prostate cancer

Agarwal, S.; Fang, L.; McGowen, K.; Yin, J.; Bowman, J.; Ku, A. T.; Alilin, A. N.; Corey, E.; Roudier, M.; True, L.; Dumpit, R.; Coleman, I.; Lee, J.; Nelson, P. S.; Senatorov, I. S.; Capaldo, B. J.; Sowalsky, A. G.; Hurt, E. M.; Kelly, K.

10.1101/2022.04.19.488784 — cancer biology — Posted on 2022-04-20

1308 Weak tension accelerates hybridization and dehybridization of short oligonucleotides

Hart, D. R.; Jeong, J.; Gumbart, J.; Kim, H. D.

10.1101/2022.04.19.488836 — biophysics — Posted on 2022-04-20

1309 The stoichiometric interaction model for mesoscopic molecular dynamics simulations of liquid-liquid phase separation

Murata, Y.; Niina, T.; Takada, S.

10.1101/2022.04.19.488761 — biophysics — Posted on 2022-04-20

1310 Brain strain rate response: addressing computational ambiguity and experimental data for model validation

Zhou, Z.; Li, X.; Liu, Y.; Hardy, W.; Kleiven, S.

10.1101/2022.02.04.478773 — bioengineering — Posted on 2022-04-20

1311 Modular safe-harbor Transgene Insertion (MosTI) for targeted single-copy and extrachromosomal array integration in C. elegans.

El Mouridi, S.; Alkhaldi, F.; Froekjaer-Jensen, C.

10.1101/2022.04.19.488726 — genetics — Posted on 2022-04-20

1312 Machine learning improves global models of plant diversity

Cai, L.; Kreft, H.; Taylor, A.; Denelle, P.; Schrader, J.; Essl, F.; Kleunen, M. v.; Pergl, J.; Pysek, P.; Stein, A.; Winter, M.; Barcelona, J. F.; Fuentes, N.; Inderjit, I.; Karger, D. N.; Kartesz, J.; Kuprijanov, A.; Nishino, M.; Nickrent, D.; Nowak, A.; Patzelt, A.; Pelser, P. B.; Singh, P.; Wieringa, J. J.; Weigelt, P.

10.1101/2022.04.08.487610 — ecology — Posted on 2022-04-20

1313 Sorting of secretory proteins at the trans-Golgi network by TGN46

Lujan, P.; Garcia-Cabau, C.; Wakana, Y.; Rodilla-Ramirez, C.; Malhotra, V.; Salvatella, X.; Garcia-Parajo, M. F.; Campelo, F.

10.1101/2022.04.20.488883 — cell biology — Posted on 2022-04-20

1314 Computing Minimal Boolean Models of Gene Regulatory Networks

Karlebach, G.; Robinson, P. N.

10.1101/2021.05.22.445266 — systems biology — Posted on 2022-04-20

1315 Intraspecific diversification and mitonuclear discordance in native versus introduced areas: co-introduction of Dolicirroplectanum lacustre, a monogenean gill parasite of the invasive Nile perch Lates niloticus

Thys, K. J. M.; Vanhove, M. P. M.; Custers, J. W. J.; Vranken, N.; Van Steenberge, M.; Kmentova, N.

10.1101/2022.02.26.482128 — evolutionary biology — Posted on 2022-04-20

1316 Duplication of NRAMP3 gene in poplars generated two homologous transporters with distinct functions

Pottier, M.; Le Thi, V. A.; Primard-Brisset, C.; Marion, J.; Bianchi, M.; Victor, C.; Dejardin, A.; Pilate, G.; Thomine, S.

10.1101/2021.12.04.471152 — evolutionary biology — Posted on 2022-04-20

1317 A motor-based approach to induce chromosome-specific mis-segregations in human cells

Truong, M. A.; Cane-Gasull, P.; de Vries, S.; Nijenhuis, W.; Wardenaar, R.; Kapitein, L.; Foijer, F.; Lens, S.

10.1101/2022.04.19.488790 — cell biology — Posted on 2022-04-20

1318 Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB

Jourevleva, K.; Golovenko, D.; Demo, G.; Dutcher, R. C.; Hall, T. M.; Zamore, P. D.; Korostelev, A. A.

10.1101/2022.04.19.488762 — molecular biology — Posted on 2022-04-20

1319 C. elegans Sine oculis/SIX-type homeobox genes act as homeotic switches to define neuronal subtype identities

Cros, C.; Hobert, O.

10.1101/2022.04.19.488792 — neuroscience — Posted on 2022-04-20

1320 Accounting for stimulations that do not elicit motor-evoked potentials when mapping cortical representations of multiple muscles

Jin, F.; Bruijn, S. M.; Daffertshofer, A.

10.1101/2021.07.29.454279 — neuroscience — Posted on 2022-04-20

1321 Binding of the peptide deformylase on the ribosome surface modulates the structure and dynamics of the exit tunnel interior

McGrath, H.; Cernekova, M.; Kolar, M. H.

10.1101/2022.04.20.488877 — biophysics — Posted on 2022-04-20

1322 Onlinemeta: A Web Server For Meta-Analysis Based On R-shiny

Yi, Y.; Lin, A.; Zhou, C.; Zhang, J.; Wang, S.; Luo, P.

10.1101/2022.04.13.488126 — bioinformatics — Posted on 2022-04-20

1323 SiCoDEA: a simple, fast and complete app for analyzing the effect of individual drugs and their combinations

Spinozzi, G.; Tini, V.; Ferrari, A.; Gionfriddo, I.; Ranieri, R.; Milano, F.; Pierangeli, S.; Donnini, S.; Silvestri, S.; Falini, B.; Martelli, M. P.

10.1101/2022.04.19.488737 — bioinformatics — Posted on 2022-04-20

1324 Comparative assessment of computed tomography and magnetic resonance imaging of the spider morph of Python regius and wild type Python regius to evaluate the morphological correlate of the wobble syndrome.

Tebruen, W.; Schrenk, F.; Kiefer, I.; Flegel, T.; Starck, M. J.; Pees, M.

10.1101/2022.03.24.485672 — genetics — Posted on 2022-04-20

1325 Reflectance spectroscopy allows rapid, accurate, and non-destructive estimates of functional traits from pressed leaves

Kothari, S.; Beauchamp-Rioux, R.; Laliberte, E.; Cavender-Bares, J.

10.1101/2021.04.21.440856 — ecology — Posted on 2022-04-20

1326 Patterned apoptosis has an instructive role for local growth and tissue shape in a fast-growing epithelium

Matamoro-Vidal, A.; Cumming, T.; Davidovic, A.; Levayer, R.

10.1101/2022.03.11.484029 — developmental biology — Posted on 2022-04-20

1327 Language and the cerebellum: structural connectivity to the eloquent brain

Jobson, K. R.; Hoffman, L. J.; Metoki, A.; Popal, H.; Dick, A. S.; Reilly, J.; Olson, I. R.

10.1101/2022.04.19.488812 — neuroscience — Posted on 2022-04-20

1328 Disruption of anterior temporal lobe reduces distortions in memory from category knowledge

Tompary, A.; Xia, A.; Coslett, H. B.; Thompson-Schill, S. L.

10.1101/2022.04.19.488831 — neuroscience — Posted on 2022-04-20

1329 Motor outcomes congruent with intentions may sharpen metacognitive representations

Charalampaki, A.; Peters, C.; Maurer, H.; Maurer, L. K.; Muller, H.; Verrel, J.; Filevich, E.

10.1101/2022.04.19.488801 — neuroscience — Posted on 2022-04-20

1330 Using total RNA quality metrics for time since deposition estimates in degrading bloodstains

Elliott, C. I.; Stotesbury, T. E.; Shafer, A. B. A.

10.1101/2021.04.28.441847 — genetics — Posted on 2022-04-19

1331 Bats as ecosystem engineers in iron ore caves in the Carajas National Forest, Brazilian Amazonia

BERNARD, E.; Pilo, L. B.; Calux, A.; Scherer, R.

10.1101/2022.04.19.488750 — ecology — Posted on 2022-04-19

1332 Dynamic Turnover of PI4P and PI(4,5)P2 under Hypoxia Controls Electrostatic Plasma Membrane Targeting

Lu, J.; Dong, W.; Hammond, G. R.; Hong, Y.

10.1101/2022.01.07.475384 — cell biology — Posted on 2022-04-19

1333 High-density transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivity

Akusobi, C.; Benghomari, B. S.; Zhu, J.; Wolf, I. D.; Singhvi, S.; Dulberger, C. L.; Ioerger, T. R.; Rubin, E. J.

10.1101/2021.07.01.450732 — microbiology — Posted on 2022-04-19

1334 Clonal spreading of tumor-infiltrating T cells underlies the robust antitumor immune responses

Aoki, H.; Tsunoda, M.; Ogiwara, H.; Shimizu, H.; Abe, H.; Abe, T.; Shichino, S.; Matsushima, K.; Ueha, S.

10.1101/2022.04.19.488731 — immunology — Posted on 2022-04-19

1335 Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala

Sydnor, V. J.; Cieslak, M.; Duprat, R.; Deluisi, J.; Flounders, M. W.; Long, H.; Scully, M.; Balderston, N. L.; Sheline, Y. I.; Bassett, D. S.; Satterthwaite, T. D.; Oathes, D. J.

10.1101/2021.11.12.468411 — neuroscience — Posted on 2022-04-19

1336 Tackling polypharmacology of kinase inhibitors and selecting chemical kinase probes by transcription factor activity profiling.

Medvedev, A.; Makarov, S.; Medvedeva, L. A.; Martsen, E.; Gorman, K. L.; Lin, B.; Makarov, S. S.

10.1101/2022.04.03.486887 — pharmacology and toxicology — Posted on 2022-04-19

1337 Phenotypic deconvolution in heterogeneous cancer cell populations using drug screening data

Köhn-Luque, A.; Myklebust, E. M.; Tadele, D. S.; Giliberto, M.; Noory, J.; Harivel, E.; Arsenteva, P.; Mumenthaler, S. M.; Schjesvold, F.; Tasken, K.; Enserink, J. M.; Leder, K.; Frigessi, A.; Foo, J.

10.1101/2022.01.17.476604 — cancer biology — Posted on 2022-04-19

1338 High resolution shotgun metagenomics: the more data, the better?

Tremblay, J.; Greer, C. W.

10.1101/2022.04.19.488797 — bioinformatics — Posted on 2022-04-19

1339 Making Common Fund data more Findable: Catalyzing a Data Ecosystem

Charbonneau, A. L.; Brady, A.; Czajkowski, K.; Aluvathingal, J.; Canchi, S.; Carter, R.; Chard, K.; Clarke, D. J. B.; Creasy, H. H.; D'Arcy, M.; Giglio, M.; Gingrich, A.; Harris, R. M.; Hodges, T. K.; Ifeonu, O.; Jeon, M.; Kropiwnicki, E.; Lim, M. C. W.; Liming, R. L.; Mandal, M.; Munro, J. B.; Nadendla, S.; Richter, R.; Romano, C.; Rocca-Serra, P.; Schuler, R. E.; Tangmunarunkit, H.; Waldrop, A.; Williams, C.; Word, K.; Sansone, S.-A.; Ma'ayan, A.; Wagner, R.; Foster, I.; Kesselman, C.; Brown, C. T.; White, O.

10.1101/2021.11.05.467504 — bioinformatics — Posted on 2022-04-19

1340 Sparse Representation Learning Derives Biological Features with Explicit Gene Weights from the Allen Mouse Brain Atlas

Abbasi, M.; Sanderford, C. R.; Raghu, N.; Pasha, M.; Bartelle, B. B.

10.1101/2021.10.11.464002 — bioinformatics — Posted on 2022-04-19

1341 Development of transformation for genome editing of an emerging model organism

Yamamoto, Y.; Gerbi, S. A.

10.1101/2022.04.19.488772 — genetics — Posted on 2022-04-19

1342 Canal number and configuration are predictors of external root morphology

Gellis, J. J.

10.1101/2022.04.19.488788 — evolutionary biology — Posted on 2022-04-19

1343 T cell Aryl Hydrocarbon Receptor Activity Tunes the Gut Microenvironment to Sustain Autoimmunity.

Merchak, A. R.; Cahill, H. J.; Brown, L. C.; Brown, R. M.; Rivet-Noor, C.; Beiter, R. M.; Slogar, E. R.; Olgun, D. G.; Gaultier, A.

10.1101/2022.04.19.488821 — immunology — Posted on 2022-04-19

1344 An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis

Karanika, S.; Gordy, J.; Neupane, P.; KARANTANOS, T.; Castillo, J.; Quijada, D.; Comstock, K.; Sandhu, A.; Hui, Y.; Ayeh, S.; Tasneen, R.; Krug, S.; Danchik, C.; Wang, T.; Schill, C.; Markham, R. t.; Karakousis, P.

10.1101/2022.04.19.488816 — immunology — Posted on 2022-04-19

1345 Transcriptome profiling of the dorsomedial prefrontal cortex in suicide victims

Dora, F.; Renner, E.; Keller, D.; Palkovits, M.; Dobolyi, A.

10.1101/2022.04.19.488577 — neuroscience — Posted on 2022-04-19

1346 Vitis vinifera plants edited in DMR6 genes show improved resistance to downy mildew.

Giacomelli, L.; Zeilmaker, T.; Scintilla, S.; Salvagnin, U.; Rouppe van der Voort, J.; Moser, C.

10.1101/2022.04.19.488768 — plant biology — Posted on 2022-04-19

1347 The mitogen-activated protein kinase kinase kinase, ILK5, regulates plant purinergic receptor-mediated, innate immunity

Kim, D.; Chen, D.; Ahsan, N.; Thelen, J. J.; Stacey, G.

10.1101/2022.04.19.488815 — plant biology — Posted on 2022-04-19

1348 Engineering and characterization of a long half-life relaxin receptor RXFP1 agonist

Erlandson, S. C.; Wang, J.; Jiang, H.; Rockman, H. A.; Kruse, A. C.

10.1101/2022.04.19.488796 — pharmacology and toxicology — Posted on 2022-04-19

1349 Tissue Specific Knockout of the Cardiolipin Transacylase Enzyme TAFAZZIN in Both Liver and Pancreatic Beta Cells Protects Mice From Diet-Induced Obesity

Cole, L. K.; Dolinsky, V. W.; Hatch, G. M.

10.1101/2022.04.19.488810 — biochemistry — Posted on 2022-04-19

1350 Clearing of ribosome collisions by the ribosome quality control trigger complex RQT

Best, K. M.; Ikeuchi, K.; Kater, L.; Best, D. M.; Musial, J.; Matsuo, Y.; Berninghausen, O.; Becker, T.; Inada, T.; Beckmann, R.

10.1101/2022.04.19.488791 — biochemistry — Posted on 2022-04-19

1351 Molecular diversity and phenotypic pleiotropy of genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their impacts on pathophysiology of Modern Humans.

Glinsky, G.

10.1101/2022.04.19.488808 — genomics — Posted on 2022-04-19

1352 High-resolution transcriptomics of bovine purified protein derivative-stimulated peripheral blood from cattle infected with Mycobacterium bovis across an experimental time course

Correia, C. N.; McHugo, G. P.; Browne, J. A.; McLoughlin, K. E.; Nalpas, N. C.; Magee, D. A.; Whelan, A. O.; Villarreal-Ramos, B.; Vordermeier, H. M.; Gormley, E.; Gordon, S. V.; MacHugh, D. E.

10.1101/2022.04.19.488769 — genomics — Posted on 2022-04-19

1353 NIPBL and WAPL balance cohesin activity to regulate chromatin folding and gene expression

Luppino, J. M.; Field, A.; Nguyen, S. C.; Park, D. S.; Shah, P. P.; Lan, Y.; Yunker, R.; Jain, R.; Adelman, K.; Joyce, E. F.

10.1101/2022.04.19.488785 — genetics — Posted on 2022-04-19

1354 Do Neotropical adult dobsonflies (Megaloptera, Corydalidae) feed on solid material in the nature? Information from a gut content study

Alvarez, H. A.; Tierno de Figueroa, J. M.; Cebada Ruiz, J. A.

10.1101/2022.04.19.488733 — ecology — Posted on 2022-04-19

1355 Why resource dynamics matter in the optimization of microbial communities

Letten, A.; Ludington, W. B.

10.1101/2022.04.19.488725 — ecology — Posted on 2022-04-19

1356 Inducing Specific Chromosome Mis-Segregation in Human Cells

Tovini, L.; Johnson, S. C.; Andersen, A. M.; Spierings, D. C. J.; Wardenaar, R.; Foijer, F.; McClelland, S. E.

10.1101/2022.04.19.486691 — cell biology — Posted on 2022-04-19

1357 Cystin is required for maintaining fibrocystin (FPC) levels and safeguarding proteome integrity in mouse renal epithelial cells Running title: Cystin deficiency reduces FPC levels through enhanced autophagic degradation.

Zhang, Y.; Yang, C.; Wang, W.; Haraffuji, N.; Bell, D. P.; Caldovic, L.; Guay-Woodford, L. M.; Bebok, Z.

10.1101/2022.04.19.488799 — cell biology — Posted on 2022-04-19

1358 eIf2α-regulated translation modulates the early adhesion of mesenchymal-like cells

Caillier, A.; Morin, N.; Lavigne, M.; Lambert, J.-P.; Mazroui, R.; Bergeman, J.; Huot, M.-E.

10.1101/2022.04.19.485843 — cell biology — Posted on 2022-04-19

1359 Nonstructural protein 1 (nsp1) widespread RNA decay phenotype varies among Coronaviruses

Bermudez, Y.; Miles, J.; Muller, M.

10.1101/2022.04.19.488803 — microbiology — Posted on 2022-04-19

1360 Functional characterization of bacterial isolates from dye decolorizing consortia and a step-up metabolic engineering based on NADH-regeneration

Rathod, J.; Archana, G.

10.1101/2022.04.19.488712 — microbiology — Posted on 2022-04-19

1361 Intercellular collectivity is governed by enzyme secretion strategies in marine polysaccharide degrading bacteria

D'Souza, G. G.; Ebrahimi, A.; Stubbusch, A.; Daniels, M.; Keegstra, J.; Stocker, R.; Cordero, O. X.; Ackermann, M.

10.1101/2022.04.19.488775 — microbiology — Posted on 2022-04-19

1362 The transcriptional regulator Sin3A balances IL-17A and Foxp3 expression in primary CD4 T cells

Perucho Aznar, L.; Icardi, L.; Di Simone, E.; Basso, V.; Zornoza, A. V.; Lozano, T.; Prosper, F.; Lasarte, J. J.; Mondino, A.

10.1101/2022.04.19.488789 — immunology — Posted on 2022-04-19

1363 Enhancing Polysaccharide Immunity through Intranasal Immunizations

Trabbic, K.; Ganesan, S.; Fattom, A.; Lees, A.; Bitko, V.

10.1101/2022.04.19.488813 — immunology — Posted on 2022-04-19

1364 Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via epigenetic regulation of key regenerative pathways

Wang, X.-W.; Yang, S.-G.; Hu, M.-W.; Wang, R.-Y.; Zhang, C.; Kosanam, A. R.; Ochuba, A. J.; Jiang, J.-J.; Luo, X.; Qian, J.; Liu, C.-M.; Zhou, F.-Q.

10.1101/2022.04.19.488817 — neuroscience — Posted on 2022-04-19

1365 Microbial mutualism generates multistable and oscillatory growth dynamics

Amchin, D. B.; Martinez-Calvo, A.; Datta, S. S.

10.1101/2022.04.19.488807 — systems biology — Posted on 2022-04-19

1366 Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators

Selvakumar, P.; Fernandez-Marino, A. I.; Khanra, N.; He, C.; Paquette, A. J.; Wang, B.; Huang, R.; Smider, V. V.; Rice, W. J.; Swartz, K. J.; Meyerson, J. R.

10.1101/2022.04.19.488765 — biophysics — Posted on 2022-04-19

1367 Nucleosome sliding by the Chd1 chromatin remodeler relies on theintegrity of the DNA duplex

Park, S.; Ha, T.; Bowman, G.

10.1101/2022.04.19.488687 — biophysics — Posted on 2022-04-19

1368 Predicting gene expression from cell morphology in human induced pluripotent stem cells

Wakui, T.; Negishi, M.; Murakami, Y.; Tominaga, S.; Shiraishi, Y.; Carpenter, A. E.; Singh, S.; Segawa, H.

10.1101/2022.04.19.488786 — bioengineering — Posted on 2022-04-19

1369 Cryo-EM structures of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae

Kishikawa, J.-i.; Ishikawa, M.; Masuya, T.; Murai, M.; Kitazumi, Y.; Butler, N.; Kato, T.; Barquera, B.; Miyoshi, H.

10.1101/2022.04.19.488743 — biochemistry — Posted on 2022-04-19

1370 COVID-19 Infection and Transmission Includes Complex Sequence Diversity

Chan, E. R.; Jones, L. D.; Linger, M.; Kovach, J. D.; Torres-Teran, M. M.; Wertz, A.; Donskey, C. J.; Zimmerman, P. A.

10.1101/2022.04.18.488717 — genomics — Posted on 2022-04-19

1371 Tracking the circulating SARS-CoV-2 variants in Turkey: Complete genome sequencing and molecular characterization of 1000 SARS-CoV-2 samples

Akcesme, F. B.; Kul Köprülü, T.; Erkal, B.; Is, S.; Cevher Keskin, B.; Akcesme, B.; Baydili, K. N.; Gezer, B.; Balkan, J.; Ucar, B.; Gürsoy, O.; Yıldız, M. T.; Kurt, H.; Ünal, N.; Altındis, M.; Korkmaz, C.; Türkez, H.; Bayraktar, O.; Demirkol, B.; Cag, Y.; Arslan, M. A.; Abakay, H.; Köse, S.; Özel, A.; Mutluay, N.; Tekin, S.

10.1101/2022.04.19.488722 — genomics — Posted on 2022-04-19

1372 Phylogeny and Metadata Network Database for Epidemiologic Surveillance

Stott, G. L.; Lyu, L.; Veytsel, G.; Kuo, J.; Lewis, R.; Brown, A.; Fujimoto, K.; Bahl, J.

10.1101/2022.04.19.488067 — evolutionary biology — Posted on 2022-04-19

1373 The Spike protein of SARS-CoV-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: implication for a role of Nrf2

Nguyen, V.; Zhang, Y.; Gao, C.; Cao, X.; Tian, Y.; Carver, W.; Kiaris, H.; Cui, T.; Tan, W.

10.1101/2022.04.19.488806 — cell biology — Posted on 2022-04-19

1374 BCG vaccination of Diversity Outbred mice induces cross-reactive antibodies to SARS-CoV-2 spike protein

Specht, A. G.; Kurtz, S. L.; Elkins, K. L.; Specht, H.; Beamer, G.

10.1101/2022.04.18.488640 — immunology — Posted on 2022-04-19

1375 An intranasal nanoparticle STING agonist has broad protective immunity against respiratory viruses and variants

Leekha, A.; Saeedi, A.; Kumar, M.; Sefat, S. R.; Paniagua, M. M.; Fathi, M.; Kulkarni, R.; Biswas, S.; Tsitoura, D.; Liu, X.; Cooper, L. J. N.; Sebastian, M.; Hurst, B. L.; Varadarajan, N.

10.1101/2022.04.18.488695 — immunology — Posted on 2022-04-19

1376 An approximate line attractor in the hypothalamus that encodes an aggressive internal state

Nair, A.; Karigo, T.; Yang, B.; Linderman, S. W.; Anderson, D. J.; Kennedy, A.

10.1101/2022.04.19.488776 — neuroscience — Posted on 2022-04-19

1377 Read2Tree: scalable and accurate phylogenetic trees from raw reads

Dylus, D.; Altenhoff, A. M.; Majidian, S.; Sedlazeck, F. J.; Dessimoz, C.

10.1101/2022.04.18.488678 — bioinformatics — Posted on 2022-04-19

1378 Persistent cross-species SARS-CoV-2 variant infectivity predicted via comparative molecular dynamics simulation

Rajendran, M.; Babbitt, G. A.

10.1101/2022.04.18.488629 — bioinformatics — Posted on 2022-04-19

1379 Redox regulation of the SARS-CoV-2 main protease provides new opportunities for drug design

Tittmann, K.; Funk, L.-M.; Poschmann, G.; Chari, A.; Rabe von Pappenheim, F.; Stegmann, K. M.; Dickmanns, A.; Eulig, N.; Wensien, M.; Paknia, E.; Heyne, G.; Penka, E.; Pearson, A. R.; Berndt, C.; Fritz, T.; Bazzi, S.; Uranga, J.; Mata, R. A.; Dobbelstein, M.; Hilgenfeld, R.; Curth, U.

10.1101/2022.04.18.487732 — biochemistry — Posted on 2022-04-19

1380 Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses using gene expression profiles of chemical and genetic perturbations

Shen, Z.; Halberg, A.; Fong, J. Y.; Guo, J.; Song, G.; Louie, B.; Luedtke, G. R.; Visuthikraisee, V.; Protter, A.; Koh, X.; Baik, T.; Lum, P. Y.

10.1101/2022.04.18.488682 — genomics — Posted on 2022-04-19

1381 Vγ9Vδ2 T cells are potent inhibitors of SARS-CoV-2 replication and exert effector phenotypes in COVID-19 patients

Gay, L.; Rouviere, M.-S.; Mezouar, S.; Richaud, M.; Gorvel, L.; Foucher, E.; Madakamutil, L.; La Scola, B.; Menard, A.; Allardet-Servent, J.; Halfon, P.; Frohna, P.; Cano, C.; Mege, J.-L.; Olive, D.

10.1101/2022.04.15.487518 — immunology — Posted on 2022-04-19

1382 Fascicles Split or Merge Every ~560 Microns Within the Human Cervical Vagus Nerve

Upadhye, A. R.; Kolluru, C.; Druschel, L.; Al Lababidi, L.; Ahmad, S.; Menendez, D.; Buyukcelik, O. N.; Settell, M. L.; Blanz, S. L.; Jenkins, M. W.; Wilson, D.; Zhang, J.; Tatsuoka, C.; Grill, W. M.; Pelot, N. A.; Ludwig, K.; Gustafson, K. J.; Shoffstall, A. J.

10.1101/2021.11.09.467343 — neuroscience — Posted on 2022-04-19

1383 MetaWorks: A flexible, scalable bioinformatic pipeline for high-throughput multi-marker biodiversity assessments

Porter, T. M.; Hajibabaei, M.

10.1101/2020.07.14.202960 — bioinformatics — Posted on 2022-04-19

1384 Transcriptomic similarities and differences between mouse models and human Alzheimer's Disease

De Bastiani, M. A.; Bellaver, B.; Carello-Collar, G.; Zimmermann, M.; Kunach, P.; Lima-Filho, R. A. S.; Forner, S.; Martini, A. C.; Pascoal, T. A.; Lourenco, M. V.; Zimmer, E. R.; Rosa-Neto, P.

10.1101/2021.06.09.447404 — neuroscience — Posted on 2022-04-19

1385 Quantifying formations of Neutravidin clusters on biotinylated mixed silane Self-Assembled Monolayers.

Ghosh, U.

10.1101/2022.03.21.485091 — bioengineering — Posted on 2022-04-19

1386 Two type II phosphatidylinositol 4-kinases function sequentially in tubule-mediated cargo delivery from early endosomes to melanosomes

Zhu, Y.; Li, S.; Jaume, A.; Jani, R. A.; Delevoye, C.; Raposo, G.; Marks, M. S.

10.1101/2021.10.19.465056 — cell biology — Posted on 2022-04-19

1387 IPMK modulates insulin-mediated suppression of hepatic glucose production

Jung, I.-R.; Anokye-Danso, F.; Jin, S.; Ahima, R. S.; Kim, S. F.

10.1101/2022.03.10.483655 — molecular biology — Posted on 2022-04-19

1388 Characterization of enterovirus D68 infection in four nonhuman primate species

Dearing, J.; Conte, A.; Brooks, C.; Zimina, A.; Rivas, R.; Birch, S. M.; Adney, D. R.; Li, M.; Rascon, A.; Belov, G. A.; Pekosz, A.; Vermillion, M. S.

10.1101/2022.04.16.487524 — microbiology — Posted on 2022-04-19

1389 Evidence for shared resources in visuospatial attention: Endogenous attention misleads the decoding of exogenous attention in alpha rhythms

Landry, M.; da Silva Castanheira, J.; Baillet, S.; Sackur, J.; Raz, A.

10.1101/2022.04.11.487868 — neuroscience — Posted on 2022-04-19

1390 3D printed SAXS chamber for controlled in-situ dialysis and optical characterization

Ehm, T.; Philipp, J.; Barkey, M.; Ober, M.; Brinkop, A. T.; Simml, D.; von Westphalen, M.; Nickel, B.; Beck-Barkai, R.; Raedler, J. O.

10.1101/2022.04.19.488724 — biophysics — Posted on 2022-04-19

1391 Chimpanzees organize their social relationships like humans

Escribano, D.; Doldan-Martelli, V.; Cronin, K. A.; Haun, D. B. M.; van Leeuwen, E. J. C.; Cuesta, J. A.; Sanchez, A.

10.1101/2022.03.16.484664 — animal behavior and cognition — Posted on 2022-04-19

1392 Failure to account for behavioral variability significantly compromises accuracy in indirect population monitoring

Wessling, E. G.; Surbeck, M.

10.1101/2021.12.22.473935 — animal behavior and cognition — Posted on 2022-04-19

1393 A quantitative, genome-wide analysis in Drosophila reveals transposable elements' influence on gene expression is species-specific

Fablet, M.; Salces-Ortiz, J.; Jacquet, A.; Menezes, B. F.; Dechaud, C.; Veber, P.; Nous, C.; Rebollo, R.; Vieira, C.

10.1101/2022.01.20.477049 — genomics — Posted on 2022-04-19

1394 Modular safe-harbor Transgene Insertion (MosTI) for targeted single-copy and extrachromosomal array integration in C. elegans.

El Mouridi, S.; Alkhaldi, F.; Froekjaer-Jensen, C.

10.1101/2022.04.19.488726 — genetics — Posted on 2022-04-19

1395 Extensive de novo activity stabilizes epigenetic inheritance of CG methylation in Arabidopsis transposons

Lyons, D. B.; Briffa, A.; He, S.; Choi, J.; Hollwey, E.; Colicchio, J.; Anderson, I.; Feng, X.; Howard, M.; Zilberman, D.

10.1101/2022.04.19.488736 — genetics — Posted on 2022-04-19

1396 Effector-mediated subversion of proteasome activator (PA)28αβ enhances lysosomal targeting of Legionella pneumophila within cytokine-activated macrophages

Ngwaga, T.; Chauhan, D.; Salberg, A. G.; Shames, S. R.

10.1101/2021.12.27.473672 — microbiology — Posted on 2022-04-19

1397 Autophagy modulates apical growth and development in the moss Physcomitrium patens

Pettinari, G. L.; Finello, J.; Plaza Rojas, M.; Liberatore, F.; Robert, G.; Otaiza-Gonzalez, S.; Velez, P.; Theumer, M.; Agudelo-Romero, P.; Gonzalez, C.; Lascano, R.; Saavedra, L. L.

10.1101/2022.04.19.488653 — plant biology — Posted on 2022-04-19

1398 Serotonin, Etonogestrel and breathing activity in murine Congenital Central Hypoventilation Syndrome

Casciato, A.; Bianchi, L.; Joubert, F.; Delucenay-Clarke, R.; Parrot, S.; Ramanantsoa, N.; Sizun, E.; Matrot, B.; Straus, C.; Similowski, T.; Cayetanot, F.; Bodineau, L.

10.1101/2022.04.19.488470 — physiology — Posted on 2022-04-19

1399 Estimation of microtubule-generated forces using a DNA origami nanospring

Nick Maleki, A.; Huis in 't Veld, P. J.; Akhmanova, A.; Dogterom, M.; Volkov, V. A.

10.1101/2022.04.19.488748 — biophysics — Posted on 2022-04-19

1400 SiCoDEA: a simple, fast and complete app for analyzing the effect of individual drugs and their combinations

Spinozzi, G.; Tini, V.; Ferrari, A.; Gionfriddo, I.; Ranieri, R.; Milano, F.; Pierangeli, S.; Donnini, S.; Silvestri, S.; Falini, B.; Martelli, M. P.

10.1101/2022.04.19.488737 — bioinformatics — Posted on 2022-04-19

1401 scAEGAN: Unification of Single-Cell Genomics Data by Adversarial Learning of Latent Space Correspondences

Khan, S.; Lehman, R.; Martinez-de-Morentin, X.; Maillo Ruiz, A.; Lagani, V.; Kiani, N.; Cabrero, D. G.; Tegner, J.

10.1101/2022.04.19.488745 — bioinformatics — Posted on 2022-04-19

1402 CPGL: Prediction of compound-protein interaction by integrating graph attention network with long short-term memory neural network

Zhao, M.; Yuan, M.; Yang, Y.; Xu, S. X.

10.1101/2022.04.19.488691 — bioinformatics — Posted on 2022-04-19

1403 Sex-dependent transcriptional control of cardiac electrophysiology by histone acetylation modifiers based on the GTEx database

Pressler, M. P.; Horvath, A.; Entcheva, E.

10.1101/2022.04.19.488752 — bioengineering — Posted on 2022-04-19

1404 MALE-MALE SOCIAL BONDING, COALITIONARY SUPPORT AND REPRODUCTIVE SUCCESS IN WILD GUINEA BABOONS

Dal Pesco, F.; Trede, F.; Zinner, D.; Fischer, J.

10.1101/2022.04.19.488751 — animal behavior and cognition — Posted on 2022-04-19

1405 Change in prey genotype frequency rescues predator from extinction

Hermann, R. J.; Becks, L.

10.1101/2022.04.19.487766 — evolutionary biology — Posted on 2022-04-19

1406 Identification and implication of tissue-enriched ligands in epithelial-endothelial crosstalk during pancreas development

Moulis, M.; Runser, S. V. M.; Glorieux, L.; Dauguet, N.; Vanderaa, C.; Gatto, L.; Tyteca, D.; Henriet, P.; Spagnoli, F. M.; Iber, D.; Pierreux, C. E.

10.1101/2022.04.19.488467 — developmental biology — Posted on 2022-04-19

1407 Deciphering the roadmap of in vivo reprogramming towards pluripotency

Chondronasiou, D.; Martinez de Villareal, J.; Melendez, E.; Lynch, C.; Kovatcheva, M.; Aguilera, M.; Prats, N.; Real, F. X.; Serrano, M.

10.1101/2022.04.19.488763 — developmental biology — Posted on 2022-04-19

1408 Gene regulation by synergism between mRNA decay and gene transcription

Garcia-Martinez, J.; Singh, A.; Medina, D. A.; Chavez, S.; Perez-Ortin, J. E.

10.1101/2022.04.19.488766 — molecular biology — Posted on 2022-04-19

1409 Wolbachia inhibits ovarian formation and increases blood avidity in female Aedes aegypti-a novel time-specific reproductive alteration

Lau, M.-J.; Ross, P. A.; Endersby-Harshman, N.; Yang, Q.; Hoffmann, A. A.

10.1101/2022.04.19.488749 — microbiology — Posted on 2022-04-19

1410 More than just hitchhikers: a survey of bacterial communities associated with diatoms originating from marine reptiles

Filek, K.; Lebbe, L.; Willems, A.; Chaerle, P.; Vyverman, W.; Zizek, M.; Bosak, S.

10.1101/2022.04.19.488760 — microbiology — Posted on 2022-04-19

1411 Epitope Mapping of SARS-CoV-2 Spike Protein Reveals Distinguishable Antibody Binding Activity of Vaccinated and Infected Individuals.

Felbinger, N.; Trudil, D. P.; Loomis, L. L.; Ascione, R.; Siragusa, G. R.; Haba, S.; Mucci, A.; Claycomb, M.; Snowberger, S.; Luke, B.; Tsang, S.; Francesconi, S. C.

10.1101/2022.04.13.487697 — immunology — Posted on 2022-04-19

1412 helixCAM: A Platform for Programmable Cellular Assembly in Bacteria and Human Cells

Chao, G.; Wannier, T. M.; Travis, C.; Borders, N. C.; Appleton, E.; Chadha, A.; Lebar, T.; Church, G. M.

10.1101/2022.04.19.488034 — synthetic biology — Posted on 2022-04-19

1413 Low Level Whole-Brain Radiation Enhances Theranostic Potential Of Single Domain Antibody Fragments For HER2-Positive Brain Metastases

Procissi, D.; Jannetti, S.; Zannikou, M.; Zhou, Z.; McDougald, D.; Kanojia, D.; Vaidyanathan, G.; Zalutsky, M. R.; Balyasnikova, I. V.

10.1101/2022.04.19.488555 — cancer biology — Posted on 2022-04-19

1414 ISM-FLUX: single-step MINFLUX with an array detector

Slenders, E.; Vicidomini, G.

10.1101/2022.04.19.488747 — biophysics — Posted on 2022-04-19

1415 Finding heterogeneously methylated genomicregions using ONT reads

Raineri, E.; Alberola, M.; Dabad, M.; Heath, S. C.

10.1101/2022.04.19.488395 — bioinformatics — Posted on 2022-04-19

1416 An objective criterion to evaluate sequence-similarity networks helps in dividing the protein family sequence space

Hornung, B.; Terrapon, N.

10.1101/2022.04.19.488343 — bioinformatics — Posted on 2022-04-19

1417 fastman: A fast algorithm for visualizing GWAS results using Manhattan and Q-Q plots

Paria, S. S.; Rahman, S. R.; Adhikari, K.

10.1101/2022.04.19.488738 — bioinformatics — Posted on 2022-04-19

1418 Predicting A/B compartments from histone modifications using deep learning

Zheng, S.; Thakkar, N.; Harris, H. L.; Zhang, M.; Liu, S.; Gerstein, M.; Aiden, E. L.; Rowley, J.; Noble, W. S.; Gursoy, G.; Singh, R.

10.1101/2022.04.19.488754 — bioinformatics — Posted on 2022-04-19

1419 Spatial and social structure of rewilded laboratory mice

Vogt, C. C.; Zipple, M.; Sprockett, D. D.; Miller, C. H.; Hardy, S.; Arthur, M.; Greenstein, A.; Colvin, M.; Moeller, A.; Sheehan, M.

10.1101/2022.04.19.488643 — animal behavior and cognition — Posted on 2022-04-19

1420 Effects of abiotic environment on invertebrate herbivory depend on plant community context in a montane grassland

Halliday, F. W.; Cappelli, S. L.; Laine, A.-L.

10.1101/2022.04.19.488732 — ecology — Posted on 2022-04-19

1421 Hidden Talents: Silent Gene Clusters Encoding Magnetic Organelle Biosynthesis in a Non-Magnetotactic Phototrophic Bacterium

Dziuba, M. V.; Paulus, A. V.; Schramm, L.; Awal, R. P.; Posfai, M.; Monteil, C.; Fouteau, S.; Uebe, R.; Schueler, D.

10.1101/2022.04.19.488322 — microbiology — Posted on 2022-04-19

1422 Clonal spreading of tumor-infiltrating T cells underlies the robust antitumor immune responses

Aoki, H.; Tsunoda, M.; Ogiwara, H.; Shimizu, H.; Abe, H.; Abe, T.; Shichino, S.; Matsushima, K.; Ueha, S.

10.1101/2022.04.19.488731 — immunology — Posted on 2022-04-19

1423 Cross-modal alterations of Alpha Activity do not reflect inhibition of early sensory processing: A frequency tagging study

Brickwedde, M.; Limachya, R.; Markiewicz, R.; Sutton, E.; Shapiro, K.; Jensen, O.; Mazaheri, A.

10.1101/2022.04.19.488727 — neuroscience — Posted on 2022-04-19

1424 Analog of Kynurenic Acid Decreases Tau Pathology by Modulating Astrogliosis in Rat Model for Tauopathy.

Majerova, P.; Olesova, D.; Golisova, G.; Buralova, M.; Michalicova, A.; Vegh, J.; Piestansky, J.; Bhide, M.; Hanes, J.; Kovac, A.

10.1101/2022.04.19.488739 — neuroscience — Posted on 2022-04-19

1425 Mechanism of dopamine traveling waves in the striatum: theory and experiment

Matityahu, L.; Gilin, N.; Atamna, Y.; Tiroshi, L.; Wickens, J. R.; Goldberg, J. A.

10.1101/2022.04.19.488647 — neuroscience — Posted on 2022-04-19

1426 Peer presence elicits task-independent changes within and beyond the mentalizing network across children and adults

Tricoche, L.; Pelisson, D.; Longo, L.; Koun, E.; Poisson, A.; Prado, J.; Meunier, M.

10.1101/2022.04.19.488718 — neuroscience — Posted on 2022-04-19

1427 Functional Recovery from Human Induced Pluripotent Stem Cell-Derived Dopamine Neuron Grafts is Dependent on Neurite Outgrowth

Hills, R.; Mossman, J. A.; Bratt-Leal, A. M.; Tran, H.; Williams, R. M.; Stouffer, D. G.; Astrovskaya, I. V.; Sanna, P. P.; Loring, J. F.; Lelos, M. J.

10.1101/2022.04.19.488213 — neuroscience — Posted on 2022-04-19

1428 A Robust Spike Sorting Method based on the Joint Optimization of Linear Discrimination Analysis and Density Peaks

Zhang, Y.; Han, J.; Liu, T.; Yang, Z.; Chen, W.; Zhang, S.

10.1101/2022.02.10.479846 — neuroscience — Posted on 2022-04-19

1429 In vitro and in vivo antioxidant therapeutic evaluation of Dodonaea viscosa Jacq.

Khan, S.; Rehman, M. U.; Khan, M. Z. I.; Muhammad, K.; Haq, I. U.; Khan, M. I.

10.1101/2022.04.17.488588 — plant biology — Posted on 2022-04-19

1430 Whole-Genome Profiling of Ethyl Methanesulfonate Mutagenesis in Tomato

Gupta, P.; Dholaniya, P. S.; Princy, K.; Madhavan, A. S.; Sreelakshmi, Y.; Sharma, R.

10.1101/2022.04.19.488728 — plant biology — Posted on 2022-04-19

1431 Incorporating selection pressures into risk predictions of chemical resistance evolution in pest organisms

Thia, J. A.; Maino, J.; Kelly, A.; Hoffmann, A. A.; Umina, P. A.

10.1101/2022.04.18.488707 — evolutionary biology — Posted on 2022-04-19

1432 The baseline immunological and hygienic status of pigs impact disease severity of African swine fever

Radulovic, E.; Mehinagic, K.; Wüthrich, T.; Hilty, M.; Posthaus, H.; Summerfield, A.; Ruggli, N.; Benarafa, C.

10.1101/2022.04.19.488723 — microbiology — Posted on 2022-04-19

1433 An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of P. aeruginosa

Koeppen, K.; Hampton, T.; Gerber, S.; Goo, Y. A.; Cho, B.-K.; Vermilyea, D.; Hogan, D.; Stanton, B.

10.1101/2022.04.19.488721 — microbiology — Posted on 2022-04-19

1434 Structure-guided investigations into HMG-CoA reductase as a herbicide target

Haywood, J.; Breese, K. J.; Zhang, J.; Waters, M. T.; Bond, C. S.; Stubbs, K. A.; Mylne, J. S.

10.1101/2022.04.18.488698 — plant biology — Posted on 2022-04-19

1435 A Chitin-Binding Protein Ultra-highly expressed in the Outer Fold of Mantle is Related to Shell Colour in Pacific Oyster Crassostrea gigas

Li, M.; Tang, J.; Huang, B.; Liu, Y.; Wei, L.; Han, Y.; Wang, X.; Sang, X.; Yuan, M.; Fan, N.; Cai, S.; Zheng, Y.; Zhang, M.; Wang, X.

10.1101/2022.04.18.488701 — physiology — Posted on 2022-04-19

1436 The role of environmental calcium in the extreme acid tolerance of northern banjo frog (Limnodynastes terraereginae) larvae

Hird, C.; Franklin, C. E.; Cramp, R. L.

10.1101/2022.04.18.488693 — physiology — Posted on 2022-04-19

1437 High-dimensional and spatial analysis reveals immune landscape dependent progression in cutaneous squamous cell carcinoma

Ferguson, A. L.; Sharman, A. R.; Allen, R. O.; Ye, T.; Lee, J. H.; Low, T.-H. H.; Ch'ng, S.; Palme, C. E.; Ashford, B.; Ranson, M.; Clark, j. R.; Patrick, E.; Gupta, R.; Palendira, U.

10.1101/2022.04.19.488697 — pathology — Posted on 2022-04-19

1438 Examining the efficacy of localised gemcitabine therapy for the treatment of pancreatic cancer using a hybrid agent-based model

Jenner, A.; Kelly, W.; Dallaston, M.; Araujo, R.; Parfitt, I.; Steinitz, D.; Pooladvand, P.; Kim, P. S.; Wade, S. J.; Vine, K. L.

10.1101/2022.04.18.488716 — cancer biology — Posted on 2022-04-19

1439 Stress fibers orient traction forces on micropatterns: A hybrid cellular Potts model study

Schakenraad, K.; Martorana, G. I.; Bakker, B. H.; Giomi, L.; Merks, R. M. H.

10.1101/2022.04.18.488715 — biophysics — Posted on 2022-04-19

1440 Ultrafast and interpretable single-cell 3D genome analysis with Fast-Higashi

Zhang, R.; Zhou, T.; Ma, J.

10.1101/2022.04.18.488683 — bioinformatics — Posted on 2022-04-19

1441 A flexible modeling and inference framework for estimating variant effect sizes from GWAS summary statistics

Spence, J. P.; Sinnott-Armstrong, N.; Assimes, T.; Pritchard, J. K.

10.1101/2022.04.18.488696 — genomics — Posted on 2022-04-19

1442 Sustained plumage divergence despite weak genomic differentiation and broad sympatry in sister species of Australian woodswallows (Artamus spp.)

Penalba, J. V.; Peters, J. L.; Joseph, L.

10.1101/2022.04.14.488308 — evolutionary biology — Posted on 2022-04-19

1443 Men in menopause? Experimental verification of the mate choice theory of menopause with Drosophila melanogaster

Singh, R. S.; Purohith, D.; Chaudhary, M.; Rajapakse, N.; Gomes, A.

10.1101/2022.04.18.488714 — evolutionary biology — Posted on 2022-04-19

1444 A multi-continental analysis of the responses of freshwater food webs to climate and land use change

Barbosa, G. P.; Siqueira, T.

10.1101/2022.04.18.488700 — ecology — Posted on 2022-04-19

1445 Sperm-mediated regulation of region-specific responses in the oviduct during establishment of pregnancy in mice

Finnerty, R. M.; Carulli, D. J.; Winuthayanon, W.

10.1101/2022.04.18.488702 — cell biology — Posted on 2022-04-19

1446 The yeast claudin Dcv1 is important for demarcating the front domain of pheromone-responding yeast cells

Sukumar, M.; DeFlorio, R.; Pai, C.-Y.; Stone, D. E.

10.1101/2022.04.18.488708 — cell biology — Posted on 2022-04-19

1447 Route of oxytetracycline administration differentially impacts the growth and gut microbiome of pigs co-infected with Bordetella bronchiseptica and Pasteurella multocida

Mou, K.; Trachsel, J.; Stephens, A.; Ricker, N.; Brockmeier, S. L.; Allen, H. K.; Loving, C. L.

10.1101/2022.04.18.488710 — microbiology — Posted on 2022-04-19

1448 Biofilms preserve transmissibility of a multi-drug resistance plasmid

Metzger, G. A.; Ridenhour, B. J.; France, M.; Gliniewicz, K.; Millstein, J.; Settles, M. L.; Forney, L. . J.; Stalder, T.; Top, E. M.

10.1101/2022.04.18.488688 — microbiology — Posted on 2022-04-19

1449 Speech understanding oppositely affectsacoustic and linguistic neural tracking in aspeech rate manipulation paradigm.

Verschueren, E.; Gillis, M.; Vanthornhout, J.; Decruy, L.; Francart, T.

10.1101/2022.02.04.479105 — neuroscience — Posted on 2022-04-19

1450 Balancing sensitivity and specificity in preclinical research

Danziger, M.; Dirnagl, U.; Toelch, U.

10.1101/2022.01.17.476585 — scientific communication and education — Posted on 2022-04-19

1451 Bleaching-resistant single-molecule fluorescence and FRET monitoring based on fluorophore exchange via transient DNA binding

Kummerlin, M.; Mazumder, A.; Kapanidis, A.

10.1101/2022.04.19.488730 — biophysics — Posted on 2022-04-19

1452 Implementing the re-use of public DIA proteomics datasets: from the PRIDE database to Expression Atlas

Walzer, M.; Garcia-Seisdedos, D.; Prakash, A.; Brack, P.; Crowther, P.; Graham, R. L.; George, N.; Mohammed, S.; Moreno, P.; Papatheodorou, I.; Hubbard, S. J.; Vizcaino, J. A.

10.1101/2021.06.08.447493 — bioinformatics — Posted on 2022-04-19

1453 reComBat: Batch effect removal in large-scale, multi-source omics data integration

Adamer, M. F.; Brueningk, S. C.; Tejada-Arranz, A.; Estermann, F.; Basler, M.; Borgwardt, K. M.

10.1101/2021.11.22.469488 — bioinformatics — Posted on 2022-04-19

1454 Identification of Cell-Type-Specific Spatially Variable Genes Accounting for Excess Zeros

Yu, J.; Luo, X.

10.1101/2021.12.27.474316 — bioinformatics — Posted on 2022-04-19

1455 Evolution of tunnels in alpha/beta-hydrolase fold proteins - what can we learn from studying epoxide hydrolases?

Bzowka, M.; Mitusinska, K.; Raczynska, A.; Skalski, T.; Samol, A.; Bagrowska, W.; Magdziarz, T.; Gora, A.

10.1101/2021.12.08.471815 — bioinformatics — Posted on 2022-04-19

1456 FastCAT accelerates absolute quantification of proteins by using multiple short non-purified chimeric standards

Rzagalinski, I.; Bogdanova, A.; Raghuraman, B. K.; Geertsma, E. R.; Hersemann, L.; Ziemssen, T.; Shevchenko, A.

10.1101/2021.12.28.474379 — biochemistry — Posted on 2022-04-19

1457 Life history traits and dispersal shape neutral genetic diversity in metapopulations

Garnier, J.; Lafontaine, P.

10.1101/2021.07.13.452195 — ecology — Posted on 2022-04-19

1458 NuRD independent Mi-2 activity represses ectopic gene expression during neuronal maturation.

Aughey, G. N.; Forsberg, E.; Grimes, K.; Zhang, S.; Southall, T. D.

10.1101/2022.04.19.488642 — developmental biology — Posted on 2022-04-19

1459 Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Fornicata

Santos, R.; Astvaldsson, A.; Pipaliya, S. V.; Zumthor, J. P.; Dacks, J. B.; Svard, S.; Hehl, A. B.; Faso, C.

10.1101/2022.04.14.488357 — cell biology — Posted on 2022-04-19

1460 Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes

Ghiaci, P.; Jouhten, P.; Martyushenko, N.; Roca-Mesa, H.; Vazquez, J.; Konstantinidis, D.; Stenberg, S.; Andrejev, S.; Grkovska, K.; Mas, A.; Casellas, G. B.; Almaas, E.; Patil, K. R.; Warringer, J.

10.1101/2022.04.18.488345 — molecular biology — Posted on 2022-04-19

1461 Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson's disease

Merk, T.; Peterson, V.; Lipski, W.; Blankertz, B.; Turner, R. S.; Li, N.; Horn, A.; Richardson, M.; Neumann, W.-J.

10.1101/2021.04.24.441207 — neuroscience — Posted on 2022-04-19

1462 Orientation dependent proton transverse relaxation in the human brain white matter: The magic angle effect on a cylindrical helix

Pang, Y.

10.1101/2021.09.13.460097 — biophysics — Posted on 2022-04-19

1463 Sequence characterization of the complete chloroplast genome of Eupatorium fortunei

yan, k.; Ran, J.; Bao, S.; Zhang, N.; Zhao, W.; Ma, Y.; Ishimwe, M. A.

10.1101/2022.04.18.488663 — bioinformatics — Posted on 2022-04-18

1464 The cost of attentional reorienting on conscious visual perception: an MEG study

Spagna, A.; Bayle, D. J.; Romeo, Z.; Seidel Malkinson, T.; Liu, J.; Yahia-Cherif, L.; Chica, A. B.; Bartolomeo, P.

10.1101/2020.12.05.413161 — neuroscience — Posted on 2022-04-18

1465 Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion

Seibert, M. J.; Evans, C. S.; Stanley, K. S.; Wu, Z.; Briguglio, J. S.; Chapman, E. R.

10.1101/2022.04.18.488681 — neuroscience — Posted on 2022-04-19

1466 Quantitative modeling demonstrates format-invariant representations of mathematical problems in the brain

Nakai, T.; Nishimoto, S.

10.1101/2022.04.18.488703 — neuroscience — Posted on 2022-04-19

1467 RadGenNets: Deep Learning-Based Radiogenomics Model For Gene Mutation Prediction In Lung Cancer

Tripathi, S.; Augustin, A. I.; Moyer, E. J.; Zavalny, A.; Dheer, S.; Sukumaran, R.; Schwartz, D.; Gorski, B.; Dako, F.; Kim, E.

10.1101/2022.04.13.488208 — cancer biology — Posted on 2022-04-18

1468 Examining clustered somatic mutations with SigProfilerClusters

Bergstrom, E. N.; Kundu, M.; Tbeileh, N.; Alexandrov, L. B.

10.1101/2022.02.11.480117 — bioinformatics — Posted on 2022-04-18

1469 Spectral clustering of single-cell multi-omics data on multilayer graphs

Zhang, S.; Leistico, J. R.; Cho, R. J.; Cheng, J. B.; Song, J. S.

10.1101/2022.01.24.477443 — bioinformatics — Posted on 2022-04-18

1470 AlphaFold Models of Small Proteins Rival the Accuracy of Solution NMR Structures

Tejero, R.; Huang, Y. J.; Ramelot, T.; Montelione, G. T.

10.1101/2022.03.09.483701 — biochemistry — Posted on 2022-04-18

1471 Western spotted skunks provide important food web linkages in forest of the Pacific Northwest

Tosa, M. I.; Lesmeister, D. B.; Levi, T.

10.1101/2022.04.01.486736 — ecology — Posted on 2022-04-18

1472 A hybrid boundary element-finite element method to solve the EEG forward problem

Dayarian, N.; Khadem, A.

10.1101/2021.12.27.474309 — neuroscience — Posted on 2022-04-18

1473 Modeling COVID-19 disease biology to identify drug treatment candidates

Jessen, W. J.; Gaisenband, S. D.; Quintanilla, M.; Lula, S.; McLeroth, P.; Sullivan, A.; Letovsky, S.

10.1101/2022.04.18.488660 — systems biology — Posted on 2022-04-18

1474 GeneticsMakie.jl: A versatile and scalable toolkit for visualizing locus-level genetic and genomic data

Kim, M.; Jops, C. T.; Gandal, M. J.

10.1101/2022.04.18.488573 — bioinformatics — Posted on 2022-04-18

1475 A coupled atrioventricular-aortic setup for in-vitro hemodynamic study of the systemic circulation: Design, Fabrication, and Physiological relevancy

Alavi, R.; Aghilinejad, A.; Wei, H.; Niroumandi, S.; Wieman, S.; Pahlevan, N. M.

10.1101/2022.04.18.488661 — bioengineering — Posted on 2022-04-18

1476 Sirtuin gene isoforms and genomic sequences of mouse and humans: Divergence across species

Zhang, X.; Wei, J. Y.; Ameer, F. S.; Azhar, G.; Crane, J.

10.1101/2022.04.18.488659 — genetics — Posted on 2022-04-18

1477 MetaRelSubNetVis: Referenceable network visualizations based on integrated patient data with group-wise comparison

Auer, F. J.; Mayer, S.; Kramer, F.

10.1101/2022.04.18.488628 — bioinformatics — Posted on 2022-04-18

1478 Phertilizer: growing a clonal tree from ultra-low coverage single-cell DNA sequencing data of tumors

Weber, L. L.; Zhang, C.; Ochoa, I.; El-Kebir, M.

10.1101/2022.04.18.488655 — bioinformatics — Posted on 2022-04-18

1479 Transcriptome-guided annotation and functional classification of long non-coding RNAs in Arabidopsis thaliana

Corona-Gomez, J. A.; Coss-Navarrete, E. L.; Garcia-Lopez, I. J.; Perez-Patino, J. A.; Fernandez-Valverde, S. L.

10.1101/2022.04.18.488676 — genomics — Posted on 2022-04-18

1480 genomeSidekick: a user-friendly epigenomics data analysis tool

Chen, J.; Zhu, A. J.; Packard, R. R. S.; Vondriska, T. M.; Chapski, D. J.

10.1101/2022.04.18.488677 — genomics — Posted on 2022-04-18

1481 Using total RNA quality metrics for time since deposition estimates in degrading bloodstains

Elliott, C. I.; Stotesbury, T. E.; Shafer, A. B. A.

10.1101/2021.04.28.441847 — genetics — Posted on 2022-04-18

1482 Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells

Pasquesi, G. I. M.; Kelly, C. J.; Ordonez, A. D.; Chuong, E. B.

10.1101/2022.04.18.488675 — evolutionary biology — Posted on 2022-04-18

1483 Severe drought events trigger long-term salt marsh dieback in the Southeastern and Gulf of Mexico USA

Rolando, J. L.; Hodges, M.; Garcia, K. D.; Krueger, G.; Williams, N.; Carr, J.; Robinson, J.; George, A.; Morris, J. T.; Kostka, J. E.

10.1101/2022.04.18.488673 — ecology — Posted on 2022-04-18

1484 Trophoblast and blood vessel organoid cultures recapitulate the role of WNT2B in promoting intravillous vascularization in human intrauterine and ectopic pregnancy

Zhao, X.; Zhang, Z.; Luo, Y.; Ye, Q.; Shi, S.; He, X.; Zhu, J.; Zhu, Q.; Zhang, D.; Xia, W.; Zhang, Y.; Jiang, L.; Cui, L.; Ye, Y.; Xiang, Y.; Hu, J.; Zhang, J.; Lin, C.-P.

10.1101/2022.04.18.488605 — cell biology — Posted on 2022-04-18

1485 HNRNPH1 destabilizes the G-quadruplex structures formed by G-rich RNA sequences that regulate the alternative splicing of an oncogenic fusion transcript

Vo, T.; Brownmiller, T.; Hall, K.; Jones, T. L.; Choudhari, S.; Grammatikakis, I.; Ludwig, K. R.; Caplen, N. J.

10.1101/2022.04.18.488656 — molecular biology — Posted on 2022-04-18

1486 Flexible control of representational dynamics in a disinhibition-based model of decision making

Shen, B.; Louie, K.; Glimcher, P. W.

10.1101/2022.04.18.488670 — neuroscience — Posted on 2022-04-18

1487 Predictable fluctuations in excitatory synaptic strength due to natural variation in presynaptic firing rate

Ren, N.; Wei, G.; Ghanbari, A.; Stevenson, I. H.

10.1101/2022.04.14.488362 — neuroscience — Posted on 2022-04-18

1488 RAPPPID: Towards Generalisable Protein Interaction Prediction with AWD-LSTM Twin Networks

Szymborski, J.; Emad, A.

10.1101/2021.08.13.456309 — systems biology — Posted on 2022-04-18

1489 Decoding nonspecific interactions between human nuclear transport proteins: A computational study

Rathod, S. B.

10.1101/2021.03.22.436462 — bioinformatics — Posted on 2022-04-18

1490 Sequence dependencies and biophysical features both govern cleavage of diverse cut-sites by HIV protease

Samant, N.; Nachum, G.; Tsepal, T.; Bolon, D.

10.1101/2022.04.18.488666 — biochemistry — Posted on 2022-04-18

1491 Homing pigeon (Columba livia) dominance hierarchies are stable over time and resistant to perturbation

Portugal, S.; Urquia-Samele, A.

10.1101/2022.04.18.488671 — animal behavior and cognition — Posted on 2022-04-18

1492 Genome-wide detection of human variants that disrupt intronic branchpoints

Zhang, P.; Philippot, Q.; Ren, W.; Lei, W.-T.; Li, J.; Stenson, P. D.; Palacin, P. S.; Colobran, R.; Boisson, B.; Zhang, S.-Y.; Puel, A.; Pan-Hammarström, Q.; Zhang, Q.; Cooper, D. N.; Abel, L.; Casanova, J.-L.

10.1101/2022.04.18.488668 — genetics — Posted on 2022-04-18

1493 Extracellular matrix assembly stress drives Drosophila central nervous system morphogenesis

Serna-Morales, E.; Sanchez-Sanchez, B. J.; Marcotti, S.; Bhargava, A.; Dragu, A.; Hirvonen, L. M.; Diaz-de-la-Loza, M.-d.-C.; Mink, M.; Cox, S.; Rayfield, E.; Stramer, B.

10.1101/2022.04.18.488510 — developmental biology — Posted on 2022-04-18

1494 Lithium-induced ciliary lengthening sparks Arp2/3 complex-dependent endocytosis

Bigge, B. M.; Avasthi, P.

10.1101/2022.04.18.488674 — cell biology — Posted on 2022-04-18

1495 SirA inhibits the essential DnaA:DnaD interaction to block helicase recruitment during Bacillus subtilis sporulation

Winterhalter, C.; Stevens, D.; Fenyk, S.; Pelliciari, S.; Marchand, E.; Soultanas, P.; Ilangovan, A.; Murray, H.

10.1101/2022.04.18.488658 — molecular biology — Posted on 2022-04-18

1496 The DNA replication initiation protein DnaD is recruited to a specific strand of the Bacillus subtilis chromosome origin

Winterhalter, C.; Pelliciari, S.; Stevens, D.; Fenyk, S.; Marchand, E.; Cronin, N.; Soultanas, P.; Costa, T.; Ilangovan, A.; Murray, H.

10.1101/2022.04.18.488654 — molecular biology — Posted on 2022-04-18

1497 The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a developmentally distinct extracellular state

Atwal, S.; Wongsantichon, J.; Giengkam, S.; Saharat, K.; Jaiyen, Y.; Chuenklin, S.; Chung, T.; Huh, H.; Lee, S.; Sobota, R.; Salje, J.

10.1101/2020.03.03.975011 — microbiology — Posted on 2022-04-18

1498 Pyochelin biotransformation shapes bacterial competition

Jenul, C.; Keim, K.; Jens, J.; Zeiler, M. J.; Schilcher, K.; Schurr, M.; Melander, C.; Phelan, V. V.; Horswill, A. R.

10.1101/2022.04.18.486787 — microbiology — Posted on 2022-04-18

1499 Neural instructive signals for associative cerebellar learning

Silva, N. T.; Ramirez-Buritica, J.; Pritchett, D. L.; Carey, M. R.

10.1101/2022.04.18.488634 — neuroscience — Posted on 2022-04-18

1500 Fleeting Effects of Incentives: Adult Age Differences in ERP Measures of Motivated Attention

Sullivan, M. D.; Kudus, F.; Dyson, B.; Spaniol, J.

10.1101/2022.04.18.488665 — neuroscience — Posted on 2022-04-18

1501 Localization, induction, and cellular effects of tau-phospho-threonine 217

Rajbanshi, B.; Mandell, J. W.; Bloom, G. S.

10.1101/2022.04.18.488657 — neuroscience — Posted on 2022-04-18

1502 Coisolation of peptide pairs for peptide identification and MS/MS-based quantification

Smith, I. R.; Eng, J. K.; Barente, A. S.; Hogrebe, A.; Llovet, A.; Rodriguez-Mias, R. A.; Villen, J.

10.1101/2022.04.18.488679 — systems biology — Posted on 2022-04-18

1503 Immunogenic cell death in mice expressing caspase-resistant ROCK1 is not replicated by ROCK inhibitors

Naylor, G.; Julian, L.; Watson-Bryce, S.; Mullin, M.; Nibbs, R. J.; Olson, M. F.

10.1101/2022.04.14.488346 — cancer biology — Posted on 2022-04-18

1504 Computational Compensatory Mutation Discovery Approach: Predicting a PARP1 Variant Rescue Mutation

Ravishankar, K.; Jiang, X.; Leddin, E. M.; Morcos, F.; Cisneros, G. A.

10.1101/2021.11.21.469407 — biophysics — Posted on 2022-04-18

1505 Making Common Fund data more Findable: Catalyzing a Data Ecosystem

10.1101/2021.11.05.467504 — bioinformatics — Posted on 2022-04-18

1506 Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes

Ghiaci, P.; Jouhten, P.; Martyushenko, N.; Roca-Mesa, H.; Vazquez, J.; Konstantinidis, D.; Stenberg, S.; Andrejev, S.; Grkovska, K.; Mas, A.; Casellas, G. B.; Almaas, E.; Patil, K. R.; Warringer, J.

10.1101/2022.04.18.488345 — bioengineering — Posted on 2022-04-18

1507 Vendor-neutral sequences (VENUS) and fully transparent workflows improve inter-vendor reproducibility of quantitative MRI

Karakuzu, A.; Biswas, L.; Cohen-Adad, J.; Stikov, N.

10.1101/2021.12.27.474259 — bioengineering — Posted on 2022-04-18

1508 A chip-based array for high-resolution fluorescence characterization of free-standing horizontal lipid membranes under voltage clamp

Ensslen, T.; Behrends, J. C.

10.1101/2022.04.18.488685 — bioengineering — Posted on 2022-04-18

1509 Reassessing the helix bundle crossing model for gating in a non-selective ion channel

Kurauskas, V.; Tonelli, M.; Henzler-Wildman, K.

10.1101/2022.04.18.488652 — biochemistry — Posted on 2022-04-18

1510 Characterizing the variation in chromosome structure ensembles in the context of the nuclear microenvironment

Das, P.; Shen, T.; McCord, R. P.

10.1101/2021.12.16.473000 — genomics — Posted on 2022-04-18

1511 A dysmorphic mouse model reveals developmental interactions of chondrocranium and dermatocranium

Motch Perrine, S. M.; Pitirri, M. K.; Durham, E. L.; Kawasaki, M.; Zheng, H.; Chen, D. Z.; Kawasaki, K.; Richtsmeier, J. T.

10.1101/2021.11.24.469914 — developmental biology — Posted on 2022-04-18

1512 Characterization of a novel amastin-like surface protein (ALSP) of Leishmania donovani, a probable lipase

Biswas, B.; Laha, B.; Sengupta, P.; Das, K.; Ghosh, M.

10.1101/2020.07.23.218107 — molecular biology — Posted on 2022-04-18

1513 Antibody escape and cryptic cross-domain stabilization in the SARS CoV-2 Omicron spike protein

Javanmardi, K.; Segall-Shapiro, T. H.; Chou, C.-W.; Boutz, D. R.; Olsen, R. J.; Xie, X.; Xia, H.; Shi, P.-Y.; Johnson, C. D.; Annapareddy, A.; Weaver, S.; Musser, J. M.; Ellington, A. D.; Finkelstein, I. J.; Gollihar, J. D.

10.1101/2022.04.18.488614 — immunology — Posted on 2022-04-18

1514 Necroptosis inhibition counteracts axonal degeneration, cognitive decline and key hallmarks of aging, promoting brain rejuvenation.

Arrazola, M. S.; Lira, M.; Quiroz, G.; Iqbal, S.; Eaton, S. L.; Kline, R. A.; Lamont, D. J.; Huerta, H.; Ureta, G.; Bernales, S.; Cardenas, J. C.; Cerpa, W.; Wishart, T. M.; Court, F. A.

10.1101/2021.11.10.468052 — neuroscience — Posted on 2022-04-18

1515 Bayesian interpolation for power laws in neural data analysis

Davidovich, I. A.; Roudi, Y.

10.1101/2022.04.15.488481 — neuroscience — Posted on 2022-04-18

1516 Large-scale exploration of whole-brain structural connectivity in anorexia nervosa: alterations in the connectivity of frontal and subcortical networks

Lloyd, E. C.; Foerde, K. E.; Muratore, A. F.; Aw, N.; Semanek, D.; Steinglass, J. E.; Posner, J.

10.1101/2021.10.05.463197 — neuroscience — Posted on 2022-04-18

1517 Ocular tropism of SARS-CoV-2 with retinal inflammation through neuronal invasion in animal models

Jeong, G. U.; Kwon, H.-J.; Moon, H. W.; Yoon, G. Y.; Shin, H. J.; Chae, J. S.; Kim, S.-J.; Lee, I.-C.; Kim, K.-D.; Ahn, D.-G.; Mahalingam, S.; Kwon, Y.-C.

10.1101/2022.04.17.488607 — microbiology — Posted on 2022-04-18

1518 Persistent Immune and Clotting Dysfunction Detected in Saliva and Blood Plasma after COVID-19

Jang, H.; Choudhury, S.; Yu, Y.; Sievers, B. L.; Gelbart, T.; Singh, H.; Rawlings, S. A.; Proal, A.; Tan, G. S.; Smith, D.; Freire, M.

10.1101/2022.03.18.484814 — immunology — Posted on 2022-04-18

1519 The SARS-CoV-2 Omicron BA.1 spike G446S potentiates HLA-A*24:02-restricted T cell immunity

Motozono, C.; Toyoda, M.; Tan, T. S.; Hamana, H.; Aritsu, Y.; Miyashita, Y.; Oshiumi, H.; Nakamura, K.; Okada, S.; Udaka, K.; Kitamatsu, M.; Kishi, H.; Ueno, T.

10.1101/2022.04.17.488095 — immunology — Posted on 2022-04-18

1520 Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression

Finlay, J. B.; Brann, D. H.; Hachem, R. A.; Jang, D. W.; Oliva, A. D.; Ko, T.; Gupta, R.; Wellford, S. A.; Moseman, E. A.; Jang, S. S.; Yan, C. H.; Matsunami, H.; Tsukahara, T.; Datta, S. R.; Goldstein, B. J.

10.1101/2022.04.17.488474 — neuroscience — Posted on 2022-04-18

1521 In Silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions

Sen, P.; Kaur, H.

10.1101/2022.04.16.488556 — bioinformatics — Posted on 2022-04-18

1522 Benchmarking the Widely Used Structure-based Binding Affinity Predictors on the Spike-ACE2 Deep Mutational Interaction Set

Samiloglu, E.; Kosaca, M.; Oktayoglu, M.; Yukruk, C.; Erguven, M.; Arslan, N.; Karakulah, G.; Barlas, A. B.; Savas, B.; Ozden, B.; Karaca, E.

10.1101/2022.04.18.488633 — bioinformatics — Posted on 2022-04-18

1523 Roles of Clamp Closing and Allosteric Effects of Discriminator and Upstream Interactions on Downstream Elements in Stabilizing an E. coli RNA Polymerase-Promoter Open Complex

Wang, H.-C.; Stroncek, K. M.; Record, T.

10.1101/2022.04.18.488589 — biophysics — Posted on 2022-04-18

1524 gr Predictor: a Deep-Learning Model for Predicting the Hydration Structures around Proteins

Kawama, K.; Fukushima, Y.; Ikeguchi, M.; Ohta, M.; Yoshidome, T.

10.1101/2022.04.18.488616 — biophysics — Posted on 2022-04-18

1525 Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes

Ghiaci, P.; Jouhten, P.; Martyushenko, N.; Roca-Mesa, H.; Vazquez, J.; Konstantinidis, D.; Stenberg, S.; Andrejev, S.; Grkovska, K.; Mas, A.; Casellas, G. B.; Almaas, E.; Patil, K. R.; Warringer, J.

10.1101/2022.04.18.488345 — bioengineering — Posted on 2022-04-18

1526 Comparative analysis of temperature preference behavior and effects of temperature on daily behavior in eleven Drosophila species

Ito, F.; Awasaki, T.

10.1101/2022.04.18.488610 — evolutionary biology — Posted on 2022-04-18

1527 Green Lacewing Chrysoperla rufilabris (Neuroptera: Chrysopidae) is a potential biological agent for controlling crapemyrtle bark scale (Hemiptera: Eriococcidae)

Wu, B.; Xie, R.; Gu, M.; Qin, H.

10.1101/2022.04.18.488594 — ecology — Posted on 2022-04-18

1528 Organelle-selective click labeling coupled with flow cytometry allows high-throughput CRISPR screening of genes involved in phosphatidylcholine metabolism

Tsuchiya, M.; Tachibana, N.; Nagao, K.; Tamura, T.; Hamachi, I.

10.1101/2022.04.18.488621 — cell biology — Posted on 2022-04-18

1529 Sensory conflict disrupts circadian rhythms in the sea anemone Nematostella vectensis.

Berger, C. A.; Tarrant, A. M.

10.1101/2022.04.11.487933 — zoology — Posted on 2022-04-18

1530 A systems biology approach to disentangle the direct and indirect effects of global transcription factors on gene expression in Escherichia coli

Iyer, M. S.; Pal, A.; Venkatesh, K. V.

10.1101/2022.04.18.488648 — systems biology — Posted on 2022-04-18

1531 Immunological Synapse Dynamics Induced by Bispecific T-cell Engagers Predict Clinical Pharmacodynamics and Tumor Evolution across Anatomical Sites

Liu, C.; Zhou, J.; Kudlacek, S.; Qi, T.; Dunlap, T.; Cao, Y.

10.1101/2022.04.18.488626 — pharmacology and toxicology — Posted on 2022-04-18

1532 Metastatic potential in clonal melanoma cells is driven by a rare, early-invading subpopulation

Kaur, A.; Kiani, K.; Fingerman, D.; Dunagin, M. C.; Li, J.; Dardani, I.; Sanford, E. M.; Pemberton, J.; Goyal, Y.; Weeraratna, A. T.; Herlyn, M.; Raj, A.

10.1101/2022.04.17.488591 — cancer biology — Posted on 2022-04-18

1533 End-to-end learning of multiple sequence alignments with differentiable Smith-Waterman

Petti, S.; Bhattacharya, N.; Rao, R.; Dauparas, J.; Thomas, N.; Zhou, J.; Rush, A. M.; Koo, P. K.; Ovchinnikov, S.

10.1101/2021.10.23.465204 — bioinformatics — Posted on 2022-04-18

1534 scTour: a deep learning architecture for robust inference and accurate prediction of cellular dynamics

Li, Q.

10.1101/2022.04.17.488600 — bioinformatics — Posted on 2022-04-18

1535 A deep reinforcement learning approach to reconstructing quaternary structures of protein dimers through self-learning

Soltanikazemi, E.; Roy, R. S.; Quadir, F.; Cheng, J.

10.1101/2022.04.17.488609 — bioinformatics — Posted on 2022-04-18

1536 Systematic classification error profoundly impacts inference in high-depth Whole Genome Shotgun Sequencing datasets

Johnson, J. B.; Sun, S.; Fodor, A.

10.1101/2022.04.04.487034 — bioinformatics — Posted on 2022-04-18

1537 Assessing sequence-based protein-protein interaction predictors for use in therapeutic peptide engineering

Charih, F.; Biggar, K. K.; Green, J. R.

10.1101/2021.09.29.462289 — bioinformatics — Posted on 2022-04-18

1538 US-align: Universal Structure Alignments of Proteins, Nucleic Acids, and Macromolecular Complexes

ZHANG, C.; Shine, M.; Pyle, A. M.; Zhang, Y.

10.1101/2022.04.18.488565 — bioinformatics — Posted on 2022-04-18

1539 TITAN: A Toolbox for Information-Theoretic Analysis of Molecular Networks

Bergmans, T.; Celikel, T.

10.1101/2022.04.18.488630 — bioinformatics — Posted on 2022-04-18

1540 The field of protein function prediction as viewed by different domain scientists

Ramola, R.; Friedberg, I.; Radivojac, P.

10.1101/2022.04.18.488641 — bioinformatics — Posted on 2022-04-18

1541 WFA-GPU: Gap-affine pairwise alignment using GPUs

Aguado-Puig, Q.; Marco-Sola, S.; Moure, J. C.; Matzoros, C.; Castells-Rufas, D.; Espinosa, A.; Moreto, M.

10.1101/2022.04.18.488374 — bioinformatics — Posted on 2022-04-18

1542 Multi-marker DNA metabarcoding detects suites of environmental gradients from an urban harbour

Robinson, C. V.; Porter, T. M.; McGee, K. M.; McCusker, M.; Wright, M. T. G.; Hajibabaei, M.

10.1101/2022.04.17.488590 — genomics — Posted on 2022-04-18

1543 Diversity chromosome evolution of Ty1-copia Retrotransposons in Pennisetum purpureum Revealed by FISH

Yu, Z. h.; Huang, Y. j.; Li, X. t.; Wu, J. y.; Zhang, M. q.; Deng, Z. h.

10.1101/2022.04.17.488575 — genetics — Posted on 2022-04-18

1544 Evolution of self-sustained circadian rhythms requires seasonal change of daylight

Seki, M.; Ito, H.

10.1101/2022.04.17.488576 — evolutionary biology — Posted on 2022-04-18

1545 The Effects of Vitamin E Analogues α-Tocopherol and γ-Tocotrienol on the Human Osteocyte Response to Ultra-high Molecular Weight Polyethylene Wear Particles

Ormsby, R. T.; Hosaka, K.; Evdokiou, A.; Odysseos, A.; Findlay, D. M.; Solomon, L. B.; Atkins, G. J.

10.1101/2022.04.17.488608 — cell biology — Posted on 2022-04-18

1546 Chlamydia trachomatis effector Dre1 interacts with dynactin to reposition host organelles during infection

Sherry, J.; Dolat, L.; MacMahon, E.; Swaney, D.; Bastidas, R.; Johnson, J. R.; Valdivia, R.; Krogan, N. J.; Elwell, C.; Engel, J.

10.1101/2022.04.15.488217 — microbiology — Posted on 2022-04-18

1547 Analysis of visual processing capabilities and neural coding strategies of a detailed model for laminar cortical microcircuits in mouse V1

Chen, G.; Scherr, F.; Maass, W.

10.1101/2021.12.07.471653 — neuroscience — Posted on 2022-04-18

1548 Insulated expression of periplasmic uricase in E. coli Nissle 1917 for the treatment of hyperuricemia

He, L.; Tang, W.; Huang, L.; Zhou, W.; Huang, S.; Zou, L.; Yuan, L.; Men, D.; Chen, S.; Hu, Y.

10.1101/2022.04.17.488604 — synthetic biology — Posted on 2022-04-18

1549 Application and Evaluation of Flipped Teaching Based on Video Conference in Standardized Training for Internal Medicine Residents during Vacation

Zhang, X.-Y.

10.1101/2022.04.17.488599 — scientific communication and education — Posted on 2022-04-18

1550 Data availability of open T-cell receptor repertoire data, a systematic assessment

Huang, Y.-N.; Patel, N. A.; Mehta, J. H.; Ginjala, S.; Brodin, P.; Gray, C. M.; Patel, Y. M.; Cowell, L. G.; Burkhardt, A. M.; Mangul, S.

10.1101/2022.04.13.488243 — scientific communication and education — Posted on 2022-04-18

1551 Public exams provide opportunities for deeper thought with less anxiety

Wiggins, B.; Lily, L.; Busch, C.; Ngwenyama, T.; Landys, M.; Shlichta, J. G.; Shi, T.

10.1101/2022.04.15.488479 — scientific communication and education — Posted on 2022-04-18

1552 In vitro and in vivo antioxidant therapeutic evaluation of Dodonaea viscosa Jacq.

Khan, S.

10.1101/2022.04.17.488588 — plant biology — Posted on 2022-04-18

1553 Ganglioside enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruption

Saha, J.; Bose, P.; Dhakal, S.; Ghosh, P.; Rangachari, V.

10.1101/2022.04.14.488413 — biophysics — Posted on 2022-04-18

1554 Where there's smoke, there's fuel: dynamic vegetation data improve predictions of wildfire hazard in the Great Basin

Smith, J. T.; Allred, B. W.; Boyd, C. S.; Davies, K. W.; Jones, M. O.; Kleinhesselink, A. R.; Maestas, J. D.; Naugle, D. E.

10.1101/2021.06.25.449963 — ecology — Posted on 2022-04-18

1555 Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1

Xu, P.-F.; Li, Y.; Cheng, T.; Zhang, Y.; Huang, Y.; Sun, X.; Wang, D.; Liu, X.; Chen, D.; Jin, X.

10.1101/2022.04.18.488635 — developmental biology — Posted on 2022-04-18

1556 Statistics of antibody binding to the spike protein explain the dependence of COVID 19 infection risk on antibody concentration and affinity

Williams, D.

10.1101/2021.10.25.465798 — immunology — Posted on 2022-04-18

1557 Bayesian inference of circular variables in ring attractor networks

Kutschireiter, A.; Basnak, M. A.; Wilson, R. I.; Drugowitsch, J.

10.1101/2021.12.17.473253 — neuroscience — Posted on 2022-04-18

1558 Synchronization in the connectome: Metastable oscillatory modes emerge from interactions in the brain spacetime network

Cabral, J.; Castaldo, F.; Vohryzek, J.; Litvak, V.; Bick, C.; Lambiotte, R.; Friston, K.; Kringelbach, M. L.; Deco, G.

10.1101/2022.01.06.475196 — neuroscience — Posted on 2022-04-18

1559 Ganglioside enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruption

Saha, J.; Bose, P.; Dhakal, S.; Ghosh, P.; Rangachari, V.

10.1101/2022.04.14.488413 — biophysics — Posted on 2022-04-18

1560 CRISPR-VAE: A Method for Explaining CRISPR/Cas12a Predictions, and an Efficiency-aware gRNA Sequence Generator

Obeid, A. S.; Al Marzouqi, H.

10.1101/2021.07.05.451176 — bioinformatics — Posted on 2022-04-18

1561 Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry

Roberts, D. S.; Mann, M.; Li, B. H.; Kim, D.; Brasier, A. R.; Jin, S.; Ge, Y.

10.1101/2022.02.09.479776 — biochemistry — Posted on 2022-04-18

1562 Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

Stalls, V.; Lindenberger, J.; Gobeil, S.; Henderson, R.; Parks, R.; Barr, M.; Deyton, M.; Martin, M.; Janowska, K.; Huang, X.; May, A.; Speakman, M.; Beaudoin, E.; Kraft, B.; Lu, X.; Edwards, R. J.; Eaton, A.; Montefiori, D.; Williams, W.; Saunders, K. O.; Wiehe, K.; Haynes, B. F.; Acharya, P.

10.1101/2022.04.07.487528 — biochemistry — Posted on 2022-04-18

1563 The cellular characterisation of SARS-CoV-2 spike protein in virus-infected cells using Receptor Binding Domain-binding specific human monoclonal antibodies.

Chan, C. E.-Z.; Ng, C.-G.; Lim, A. P. C.; Seah, S. G.-K.; Chye, D. H.; Wong, S. K. K.; Lim, J.-H.; Lim, V. Z.-Y.; Lai, S. K.; Wong, P.-S.; Leong, K.-M.; Liu, Y.; Sugrue, R.; Tan, B. H.

10.1101/2021.12.06.471528 — microbiology — Posted on 2022-04-18

1564 Mucosal Immunization of Cynomolgus Macaques with Adenoviral Vector Vaccine Elicits Neutralizing Nasal and Serum Antibody to Several SARS-CoV-2 Variants

Flitter, B. A.; Lester, C. A.; Tedjakusuma, S. N.; Dora, E. G.; Peinovich, N.; Cortese, M.; Martinez, C. I.; Jegede, C. B.; Neuhaus, E. D.; Tucker, S. N.

10.1101/2022.02.21.481345 — immunology — Posted on 2022-04-18

1565 Exploring the structural basis to develop efficient multi-epitope vaccines displaying interaction with HLA and TAP and TLR3 molecules to prevent NIPAH infection, a global threat to human health

Srivastava, S.; Verma, S.; Kamthania, M.; Saxena, A. K.; Pandey, K.; Kolbe, M.

10.1101/2021.09.17.460735 — immunology — Posted on 2022-04-18

1566 Proinflammatory innate cytokines and metabolomic signatures predict T cell response in active COVID-19

Binayke, A.; Zaheer, A.; Dandotiya, J.; Gupta, S. K.; Mani, S.; Tripathy, M. R.; Madan, U.; Shrivastava, T.; Kumar, Y.; Pandey, A. K.; Rathore, D. K.; Awasthi, A.

10.1101/2022.03.11.483930 — immunology — Posted on 2022-04-18

1567 Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.1 and BA.2 variants and their mouse origins

Xu, Y.; Wu, C.; Cao, X.; Gu, C.; Liu, H.; Jiang, M.; Wang, X.; Yuan, Q.; Wu, K.; Liu, J.; He, X.; Wang, D.; Wang, X.; Deng, S.-J.; Xu, H. E.; Yin, W.

10.1101/2022.04.12.488075 — biophysics — Posted on 2022-04-18

1568 Identification of consensus hairpin loop structure among the negative sense sub-genomic RNAs of SARS-CoV-2

Bokolia, N. P.; Gadepalli, R.

10.1101/2022.03.25.485826 — bioinformatics — Posted on 2022-04-18

1569 The impacts of transfer learning, phylogenetic distance, and sample size on big-data bioacoustics

Provost, K. L.; Yang, J.; Carstens, B. C.

10.1101/2022.02.24.481827 — evolutionary biology — Posted on 2022-04-18

1570 p73 controls cell junction dynamics during sprouting angiogenesis and acts via Angiomotin

Maeso-Alonso, L.; Alonso-Olivares, H.; Martinez-Garcia, N.; Villoch-Fernandez, J.; Puente-Santamaria, L.; Colas-Algora, N.; Fernandez-Corona, A.; Lorenzo-Marcos, M. E.; Jimenez, B.; Holmgren, L.; Wilhelm, M.; Millan, J.; del Peso, L.; Claesson-Welsh, L.; Marques, M. M.; Marin, M. C.

10.1101/2022.03.03.482832 — cell biology — Posted on 2022-04-18

1571 On the use of relative brain size

Smeele, S. Q.

10.1101/2022.03.15.484414 — evolutionary biology — Posted on 2022-04-18

1572 Deconvoluting signals downstream of growth and immune receptor kinases by phosphocodes of the BSU1 family phosphatases

Park, C. H.; Bi, Y.; Youn, J.-H.; Kim, S.-H.; Kim, J.-G.; Xu, N.; Shrestha, R.; Burlingame, A. L.; Xu, S.-L.; Mudgett, M. B.; Kim, S.-K.; Kim, T.-W.; Wang, Z.-Y.

10.1101/685610 — plant biology — Posted on 2022-04-18

1573 Agrobacterium mediated transformation and deciphering SNPs in TaLr67 gene homeologs for gene editing in wheat.

Thiyagarajan, K.; Noguera, L. M.; Pacheco, M.; Govindan, V.; Vikram, P.

10.1101/2022.03.23.485492 — molecular biology — Posted on 2022-04-18

1574 Influence of DNA extraction kits on freshwater fungal DNA metabarcoding

Matsuoka, S.; Sugiyama, Y.; Nagano, M.; Doi, H.

10.1101/2021.10.19.464972 — microbiology — Posted on 2022-04-18

1575 A repertoire of foraging decision variables in the mouse brain

Cazettes, F.; Murakami, M.; Morais, J. P.; Renart, A.; Mainen, Z.

10.1101/2021.04.01.438090 — neuroscience — Posted on 2022-04-18

1576 Single-cell generalized trend model (scGTM): a flexible and interpretable model of gene expression trend along cell pseudotime

Cui, E. H.; Wong, W. K.; Song, D.; Li, J. J.

10.1101/2021.11.25.470059 — bioinformatics — Posted on 2022-04-18

1577 Comparative analysis reveals the long-term co-evolutionary history of parvoviruses and vertebrates.

Campbell, M. A.; Loncar, S.; Kotin, R.; Gifford, R. J.

10.1101/2021.10.25.465781 — evolutionary biology — Posted on 2022-04-18

1578 HOPX governs a molecular and physiological switch between cardiomyocyte progenitor and maturation gene programs

Friedman, C.; Cheetham, S.; Mills, R.; Ogawa, M.; Redd, M.; Chiu, H.; Shen, S.; Sun, Y.; Mizikovsky, D.; Bouveret, R.; Chen, X.; Voges, H.; Paterson, S.; De Angelis, J.; Andersen, S.; Yoon, S.; Faulkner, G.; Smith, K.; Harvey, R.; Hogan, B.; Nguyen, Q.; Kikuchi, K.; Hudson, J.; Palpant, N.

10.1101/2022.04.17.488603 — developmental biology — Posted on 2022-04-17

1579 HiCHub: A Network-Based Approach to Identify Domains of Differential Interactions from 3D Genome Data

Li, X.; Yuan, S.; Zhu, S.; Xue, H.; Peng, W.

10.1101/2022.04.16.488566 — bioinformatics — Posted on 2022-04-17

1580 Oculomotor plant and neural dynamics suggest gaze control requires integration on distributed timescales

Miri, A.; Bhasin, B. J.; Aksay, E. R. F.; Tank, D. W.; Goldman, M. S.

10.1101/2021.06.30.450653 — neuroscience — Posted on 2022-04-17

1581 Predicting modular functions and neural coding of behavior from a synaptic wiring diagram

Vishwanathan, A.; Ramirez, A.; Wu, J.; Sood, A.; Yang, R.; Kemnitz, N.; Ih, D.; Turner, N.; Lee, K.; Tartavull, I.; Silversmith, W. M.; Jordan, C. S.; David, C.; Bland, D.; Goldman, M. S.; Aksay, E.; Seung, H. S.

10.1101/2020.10.28.359620 — neuroscience — Posted on 2022-04-17

1582 A cobB like protein in Oryza sativa indica regulates the mitochondrial machinery under stress conditions

Dey, S.; Khan, S.; Mitra, N.

10.1101/2022.04.17.488584 — plant biology — Posted on 2022-04-17

1583 An adaptive teosinte mexicana introgression modulates phosphatidylcholine levels and is associated with maize flowering time

Barnes, A. C.; Rodriguez-Zapata, F.; Blocher-Juarez, K. A.; Gates, D. J.; Janzen, G. M.; Kur, A.; Wang, L.; Jensen, S. E.; Estevez-Palmas, J. M. M.; Crow, T. M.; Kavi, H. S.; Pil, H. D.; Stokes, R. L.; Knizner, K. T.; Aguilar-Rangel, M. R.; Demesa-Arevalo, E.; Skopelitis, T.; Perez-Limon, S.; Stutts, W. L.; Thompson, P.; Chiu, Y.-C.; Jackson, D.; Muddiman, D. C.; Fiehn, O.; Runcie, D.; Buckler, E. S.; Ross-Ibarra, J.; Hufford, M. B.; Sawers, R. J.; Rellan-Alvarez, R.

10.1101/2021.01.25.426574 — plant biology — Posted on 2022-04-17

1584 MetaTrass: High-quality metagenome assembly on the human gut microbiome by co-barcoding sequencing reads

Qi, Y.; Gu, S.; Zhang, Y.; Guo, L.; Xu, M.; Cheng, X.; Wang, O.; Chen, J.; Fang, X.; Liu, X.; Deng, L.; Fan, G.

10.1101/2021.09.13.459686 — bioinformatics — Posted on 2022-04-17

1585 Whole brain network analysis of neural synchrony and information flow during transition from wakefulness to light non-rapid eye movement sleep

Fan, J. M.; Kudo, K.; Verma, P.; Ranasinghe, K. G.; Morise, H.; Findlay, A. M.; Vossel, K. A.; Kirsch, H. E.; Raj, A.; Krystal, A. D.; Nagarajan, S. S.

10.1101/2022.03.09.483562 — bioengineering — Posted on 2022-04-17

1586 Canine saliva is a source of interspecies antimicrobial resistance gene transfer

Toth, A. G.; Toth, I.; Rozsa, B.; Kovacs, E. G.; Dubecz, A.; Patai, A. V.; Nemeth, T.; Kaplan, S.; Makrai, L.; Solymosi, N.

10.1101/2022.03.07.483304 — genomics — Posted on 2022-04-17

1587 Live Analysis of Position Effect Variegation (PEV) in Drosophila Reveals Different Modes of Action for HP1a and Su(var)3-9

Maggert, K. A.; Bughio, F. J.

10.1101/2021.10.10.463835 — genetics — Posted on 2022-04-17

1588 Uncovering the "ZIP code" for bZIP dimers reveals novel motifs, regulatory rules and one billion years of cis-element evolution

Li, M.; Lin, W.; Hinckley, W. E.; Yao, T.; Muchero, W.; Chen, J.; Huang, S.-s. C.

10.1101/2022.04.17.488518 — molecular biology — Posted on 2022-04-17

1589 Newly discovered alleles of the tomato antiflorigen gene SELF PRUNING provide a range of plant compactness and yield

Kang, M.-S.; Kim, Y. J.; Heo, J.; Rajendran, S.; Wang, X.; Bae, J. H.; Lippman, Z.; Park, S. J.

10.1101/2022.04.17.488597 — plant biology — Posted on 2022-04-17

1590 The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains

Sych, T.; Omidvar, R.; Ostmann, R.; Schubert, T.; Brandel, A.; Richert, L.; Mely, Y.; Madl, J.; Roemer, W.

10.1101/2022.04.17.488572 — biophysics — Posted on 2022-04-17

1591 MetaPhage: an automated pipeline for analyzing, annotating, and classifying bacteriophages in metagenomics sequencing data.

Pandolfo, M.; Telatin, A.; Lazzari, G.; Adriaenssens, E. M.; Vitulo, N.

10.1101/2022.04.17.488583 — bioinformatics — Posted on 2022-04-17

1592 SOAR: a spatial transcriptomics analysis resource to model spatial variability and cell type interactions

Li, Y.; Dennis, S.; Hutch, M.; Li, Y.; Broad, M.; Zeng, Z.; Luo, Y.

10.1101/2022.04.17.488596 — bioinformatics — Posted on 2022-04-17

1593 HiCHub: A Network-Based Approach to Identify Domains of Differential Interactions from 3D Genome Data

Peng, W.; Yuan, S.; Li, X.; Zhu, S.; Xue, H.

10.1101/2022.04.16.488566 — bioinformatics — Posted on 2022-04-17

1594 Inferring functions of coding and non-coding genes using epigenomic patterns and deciphering the effect of combinatorics of transcription factors binding at promoters

Chandra, O.; Sharma, M.; Pandey, N.; Jha, I. P.; Mishra, S.; Kong, S. L.; KUMAR, V.

10.1101/2022.04.17.488570 — bioinformatics — Posted on 2022-04-17

1595 Subchondral bone and synovial fluid metabolomic profiles are altered in injured and contralateral limbs 7 days after non-invasive joint injury in skeletally-mature C57BL/6 mice

Hislop, B.; Devine, C.; June, R. K.; Heveran, C. M.

10.1101/2022.04.16.488558 — bioengineering — Posted on 2022-04-17

1596 Calculating ATP production rates from oxidative phosphorylation and glycolysis during cell activation

Desousa, B. R.; Kim, K. K. O.; Hsieh, W. Y.; Jones, A. E.; Swain, P.; Morrow, D. H.; Ferrick, D. A.; Shirihai, O. S.; Neilson, A.; Nathanson, D. A.; Rogers, G. W.; Dranka, B. P.; Murphy, A. N.; Affourtit, C.; Bensinger, S. J.; Stiles, L.; Romero, N.; Divakaruni, A. S.

10.1101/2022.04.16.488523 — biochemistry — Posted on 2022-04-17

1597 An atlas of genetic scores to predict multi-omic traits

Xu, Y.; Ritchie, S. C.; Liang, Y.; Timmers, P. R. H. J.; Pietzner, M.; Lannelongue, L.; Lambert, S. A.; Tahir, U. A.; May-Wilson, S.; Johansson, Åsa; Surendran, P.; Nath, A. P.; Persyn, E.; Peters, J. E.; Oliver-Williams, C.; Deng, S.; Prins, B.; Foguet, C.; Luan, J.; Bomba, L.; Soranzo, N.; Angelantonio, E. D.; Pirastu, N.; Tai, E. S.; van Dam, R. M.; Davenport, E. E.; Paul, D. S.; Yau, C.; Gerszten, R. E.; Mälarstig, A.; Danesh, J.; Sim, X.; Langenberg, C.; Wilson, J. F.; Butterworth, A. S.; Inouye, M.

10.1101/2022.04.17.488593 — genomics — Posted on 2022-04-17

1598 Development of a high-density 665 K SNP array for rainbow trout genome-wide genotyping

Bernard, M.; Dehaullon, A.; Gao, G.; Paul, K.; Lagarde, H.; Charles, M.; Prchal, M.; Danon, J.; Jaffrelo, L.; Poncet, C.; Patrice, P.; Haffray, P.; Quillet, E.; Dupont-Nivet, M.; Palti, Y.; Lallias, D.; Phocas, F.

10.1101/2022.04.17.488574 — genomics — Posted on 2022-04-17

1599 Gene editing is suitable to treat GM1 Gangliosidosis: a proof-of-concept study

Leclerc, D.; Goujon, L.; Jaillard, S.; Nouyou, B.; Cluzeau, L.; Damaj, L.; Dubourg, C.; Etcheverry, A.; Levade, T.; Froissart, R.; Dreano, S.; Guillory, X.; Eriksson, L. A.; Launay, E.; Mouriaux, F.; Belaud-Rotureau, M.-A.; Odent, S.; Gilot, D.

10.1101/2022.04.17.488473 — genetics — Posted on 2022-04-17

1600 Characterization of enterovirus D68 infection in four nonhuman primate species

Dearing, J.; Conte, A.; Brooks, C.; Zimina, A.; Birch, S. M.; Adney, D. R.; Li, M.; Rascon, A.; Belov, G. A.; Pekosz, A.; Vermillion, M. S.

10.1101/2022.04.16.487524 — microbiology — Posted on 2022-04-17

1601 CD200R1 promotes IL-17 production by ILC3s, by enhancing STAT3 activation

Linley, H.; Ogden, A.; Jaigirdar, S.; Buckingham, L.; Cox, J.; Priestley, M.; Saunders, A.

10.1101/2022.04.17.488595 — immunology — Posted on 2022-04-17

1602 Peptidergic signaling controls the dynamics of sickness behavior in Caenorhabditis elegans

Marquina-Solis, J.; Vandewyver, E.; Hawk, J.; Colon-Ramos, D.; Beets, I.; Bargmann, C.

10.1101/2022.04.16.488560 — neuroscience — Posted on 2022-04-17

1603 mGlu2 and mGlu3 receptor negative allosteric modulators affect the discriminative stimulus effects of alcohol

Tyler, R. E.; Blough, B. E.; Landavazo, A.; Besheer, J.

10.1101/2022.04.16.488559 — neuroscience — Posted on 2022-04-17

1604 Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia

Zhang, Y.-Q.; Chen, L.-q.; Lv, X.-j.; Guo, Q.-H.; Lv, S.-s.; Lv, N.; Jin, Y.; Xu, W.-d.

10.1101/2022.04.16.488241 — neuroscience — Posted on 2022-04-17

1605 Dual orexin antagonist DORA-22 suppressed posttraumatic seizures and enhances GABAergic inhibition in dentate granule cells

Maganti, R.; Konduru, S. S.; Isaacson, J. R.; Zhou, Z.; Rao, R. K.; Lasky, D. J.; Rewey, S. j.; Vattem, S. S.; Jones, M.

10.1101/2022.04.17.488582 — neuroscience — Posted on 2022-04-17

1606 Plant-on-Chip: core morphogenesis processes in the tiny plant Wolffia australiana

Li, F.; Yang, J.-J.; Sun, Z.-Y.; Wang, L.; Qi, L.-Y.; A, S.; Liu, Y.-Q.; Zhang, H.-M.; Dang, L.-F.; Wang, S.-J.; Luo, C.-X.; Nian, W.-F.; O'Conner, S.; Ju, L.-Z.; Quan, W.-P.; Li, X.-K.; Wang, C.; Wang, D.-P.; You, H.-L.; Cheng, Z.-K.; Yan, J.; Tang, F.-C.; Yang, D.-C.; Xia, C.-W.; Gao, G.; Wang, Y.; Zhang, B.-C.; Zhou, Y.-H.; Guo, X.; Xiang, S.-H.; Liu, H.; Peng, T.-B.; Su, X.-D.; Chen, Y.; Ouyang, Q.; Wang, D.-H.; Zhang, D.-M.; Xu, Z.-H.; Hou, H.-W.; Bai, S.-N.; Li, L.

10.1101/2022.04.16.488569 — plant biology — Posted on 2022-04-17

1607 Protein kinase D promotes prostate cancer cell bone metastasis by positively regulating Runx2 in a MEK/ERK1/2-dependent manner

Roy, A.; Prasad, S.; Chao, Y.; Zhao, J.; Wang, Q.

10.1101/2022.04.16.488551 — cancer biology — Posted on 2022-04-17

1608 Structural dynamics of Zika Virus NS1 via a reductionist approach reveal the disordered nature of its beta roll domain in isolation

Kapuganti, S. K.; Kumar, P.; Giri, R.

10.1101/2022.04.16.488568 — biophysics — Posted on 2022-04-17

1609 A fijivirus major viroplasm protein shows RNA-stimulated ATPase activity by adopting pentameric and hexameric assemblies of dimers

Llauger, G.; Melero, R.; Monti, D.; Sycz, G.; Huck-Iriart, C.; Cerutti, M. L.; Klinke, S.; Mikkelsen, E.; Tijman, A.; Arranz, R.; Alfonso, V.; Arellano, S. M.; Goldbaum, F. A.; Sterckx, Y. G. J.; Carazo, J.-M.; Kaufman, S. B.; Dans, P. D.; del Vas, M.; Otero, L. H.

10.1101/2022.04.16.488468 — biochemistry — Posted on 2022-04-17

1610 Improved metabolic syndrome and timing of weight loss is crucial for influenza vaccine-induced immunity in obese mice

Honce, R.; Vazquez-Pagan, A.; Livingston, B.; Cherry, S.; Hargest, V.; Sharp, B.; Van de Velde, L.-A.; Skinner, R. C.; Thomas, P. G.; Schultz-Cherry, S.

10.1101/2022.04.16.488487 — microbiology — Posted on 2022-04-17

1611 Accelerated mass transfer from frozen thin films during thin-film freeze-drying

Wang, J.-L.; Kuang, M.; Xu, H.; Williams, R. O.; Cui, Z.

10.1101/2022.04.16.488553 — pharmacology and toxicology — Posted on 2022-04-17

1612 Wide-Field Multicontrast Nonlinear Microscopy for Histopathology

Uribe Casta~no, L.; Mirsanaye, K.; Golaraei, A.; Kontenis, L.; Done, S. J.; Stambolic, V.; Akens, M.; Wilson, B.; Barzda, V.

10.1101/2022.04.16.488489 — biophysics — Posted on 2022-04-17

1613 ModCRE: a structure homology-modeling approach to predict TF binding in cis-regulatory elements

Fornes, O.; Meseguer, A.; Aguirre-Plans, J.; GOHL, P.; Mireia-Bota, P.; MOLINA-FERNANDEZ, R.; BONET, J.; CHINCHILLA, A.; PEGENAUTE, F.; Gallego, O.; Fernandez-Fuentes, N.; Oliva, B.

10.1101/2022.04.17.488557 — bioinformatics — Posted on 2022-04-17

1614 Meta-analysis using new methods for three-stressor combinations reveal substantial higher-order interactions and emergent properties

Diamant, E. S.; Boyd, S.; Lozano-Huntelman, N. A.; Enriquez, V.; Kim, A. R.; Savage, V. M.; Yeh, P. J.

10.1101/2022.04.15.488520 — ecology — Posted on 2022-04-17

1615 Vibrio tarriae sp. nov., a novel member of the Cholerae clade isolated from across the United States

Islam, M. T.; Liang, K.; Orata, F.; Im, M. S.; Alam, M.; Lee, C. C.; Boucher, Y. F.

10.1101/2022.04.17.488585 — microbiology — Posted on 2022-04-17

1616 Rethinking the Methods and Algorithms for Inner Speech Decoding - and Making them Reproducible

Simistira Liwicki, F.; Gupta, V.; Saini, R.; De, K.; Liwicki, M.

10.1101/2022.03.22.485286 — neuroscience — Posted on 2022-04-17

1617 All-optical visualization of specific molecules in the ultrastructural context of brain tissue

M'Saad, O.; Kasula, R.; Kondratiuk, I.; Kidd, P.; Falahati, H.; Gentile, J. E.; Niescier, R. F.; Watters, K.; Sterner, R. C.; Lee, S.; Liu, X.; De Camilli, P.; Rothman, J. E.; Koleske, A. J.; Biederer, T.; Bewersdorf, J.

10.1101/2022.04.04.486901 — neuroscience — Posted on 2022-04-17

1618 Scanning Single Molecule Localization Microscopy (scanSMLM) for super-resolution optical volume imaging

Basumatary, J.; Baro, N.; Joshi, P.; Mondal, P. P.

10.1101/2022.04.01.486682 — biophysics — Posted on 2022-04-17

1619 Only 2 of 12 now-deleted genes of 19 identified and predicted Myb family DNA binding proteins are directly involved in rice Magnaporthe oryzae pathogenicity

Li, Y.; Zheng, X.; Pei, M.; Chen, M.; Zhang, S.; Liang, C.; Gao, L.; Huang, P.; Olsson, S.

10.1101/2021.12.28.474317 — microbiology — Posted on 2022-04-17

1620 Opponent learning with different representations in the cortico-basal ganglia circuits

Morita, K.; Shimomura, K.; Kawaguchi, Y.

10.1101/2021.10.29.466375 — neuroscience — Posted on 2022-04-17

1621 Functional MRI of large scale activity in behaving mice

Fonseca, M. S.; Bergomi, M. G.; Mainen, Z. F.; Shemesh, N.

10.1101/2020.04.16.044941 — neuroscience — Posted on 2022-04-17

1622 Nuclear Progestin Receptor Mediated Linkage of Blood Coagulation and Ovulation

Huang, J.; Chao, S.; Liu, D.; Zhao, N.; Shavit, J. A.; Zhu, Y.; Chen, S.

10.1101/2021.11.08.467707 — physiology — Posted on 2022-04-17

1623 Adaptive cognitive maps for curved surfaces in the 3D world

Kim, M.; Doeller, C. F.

10.1101/2021.08.30.458179 — neuroscience — Posted on 2022-04-17

1624 Dynamic mode structure of active turbulence

Henshaw, R. J.; Martin, O. G.; Guasto, J. S.

10.1101/2022.04.15.488501 — biophysics — Posted on 2022-04-17

1625 Variation in Ubiquitin System Genes Creates Substrate-Specific Effects on Proteasomal Protein Degradation

Collins, M. A.; Mekonnen, G.; Albert, F. W.

10.1101/2021.05.05.442832 — genetics — Posted on 2022-04-16

1626 Effects of climate warming on the pine processionary moth at the southern edge of its range: a retrospective analysis on egg survival in Tunisia

Bourougaaoui, A.; Robinet, C.; Ben Jamaa, M. L.; Laparie, M.

10.1101/2021.08.17.456665 — ecology — Posted on 2022-04-16

1627 Contribution of markers of adiposopathy and adipose cell size in predicting insulin resistance markers in women of varying age and adiposity

Tremblay, E.-J.; Tchernof, A.; Pelletier, M.; Chabot, N.; Joanisse, D. R.; Mauriege, P.

10.1101/2021.11.03.467138 — cell biology — Posted on 2022-04-16

1628 Structure of the Dengue Virus RNA Promoter

Sun, Y.-T.; Varani, G.

10.1101/2022.04.15.488410 — biochemistry — Posted on 2022-04-16

1629 Data availability of open T-cell receptor repertoire data, a systematic assessment

Huang, Y.-N.; Patel, N. A.; Mehta, J. H.; Ginjala, S.; Brodin, P.; Gray, C. M.; Patel, Y. M.; Cowell, L. G.; Burkhardt, A. M.; Mangul, S.

10.1101/2022.04.13.488243 — scientific communication and education — Posted on 2022-04-16

1630 Global shark species richness is more constrained by energy than evolutionary history

Sheahan, E. R.; Naylor, G. J. P.; McGlinn, D. J.

10.1101/2022.04.15.488537 — ecology — Posted on 2022-04-16

1631 Induction of a CD8 T cell intrinsic DNA damage and repair response is associated with clinical response to PD-1 blockade in uterine cancer.

Muroyama, Y.; Manne, S.; Wellhausen, N.; Oldridge, D. A.; Greenplate, A. R.; Chilukuri, L.; Mathew, D.; Xu, C.; Herati, R. S.; Berger, S. L.; Huang, A. C.; June, C. H.; Zamarin, D.; Friedman, C. F.; Wherry, E. J.

10.1101/2022.04.16.488552 — immunology — Posted on 2022-04-16

1632 Limitations of composability of cis-regulatory elements in messenger RNA

Auxillos, J. Y.; Haynes, S. J.; Jain, A.; Alibert, C.; Danecka, W.; Wallace, E. W. J.

10.1101/2021.08.12.455418 — systems biology — Posted on 2022-04-16

1633 Quantitative landscapes reveal trajectories of cell-state transitions associated with drug resistance in melanoma

Pillai, M.; Chen, Z.; Jolly, M. K.; Li, C.

10.1101/2022.04.16.488373 — systems biology — Posted on 2022-04-16

1634 Evaluation of Nav1.8 as a therapeutic target for Pitt Hopkins Syndrome

Martinowich, K.; Das, D.; Sripathy, S. R.; Maher, B. J.

10.1101/2022.04.15.488505 — neuroscience — Posted on 2022-04-16

1635 Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling

Nakamura, Y.; Yahiro, T.; Kataoka, N.; Hioki, H.; Nakamura, K.

10.1101/2022.04.15.488488 — physiology — Posted on 2022-04-16

1636 C/EBPα confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress in FLT3-mutant leukemia

Sabatier, M.; Birsen, R.; Tamburini, J.; Sarry, J.-E.

10.1101/2022.04.15.488522 — cancer biology — Posted on 2022-04-16

1637 Quantitative MHC class-I/-II expression levels in CDK12 mutated prostate cancer patients reveal intratumorally T cell adaptive immune response in tumors

Lautert-Dutra, W.; Melo, C. M.; Chavez, L. P.; dos Reis, R. B.; Squire, J. A.

10.1101/2022.04.16.487364 — cancer biology — Posted on 2022-04-16

1638 Chronically radiation-exposed survivor glioblastoma cells display poor response to Chk1 inhibition

Pinarbasi Degirmenci, N.; Sur-Erdem, I.; Akcay, V.; Bolukbasi, Y.; Selek, U.; Solaroglu, I.; Bagci-Onder, T.

10.1101/2022.04.16.488495 — cancer biology — Posted on 2022-04-16

1639 Cell-free Protein Crystallization for Nanocrystal Structure Determination

Abe, S.; Tanaka, J.; Kojima, M.; Kanamaru, S.; Hirata, K.; Yamashita, K.; Kobayashi, A.; Ueno, T.

10.1101/2022.04.15.488232 — biophysics — Posted on 2022-04-16

1640 Structural and Dynamic Effects of PTEN C-terminal Tail Phosphorylation

Smith, I. N.; Dawson, J. E.; Krieger, J. M.; Thacker, S.; Bahar, I.; Eng, C.

10.1101/2022.04.16.488508 — biophysics — Posted on 2022-04-16

1641 Dynamic cholesterol redistribution favors membrane fusion pore constriction

Beaven, A. H.; Sapp, K. C.; Sodt, A. J.

10.1101/2022.04.15.488512 — biophysics — Posted on 2022-04-16

1642 Analysis of chemical and mechanical behaviors in living cells by continuum mechanics-based FRAP

Saito, T.; Matsunaga, D.; Deguchi, S.

10.1101/2022.04.16.488540 — biophysics — Posted on 2022-04-16

1643 A Kinetic Map of the Influence of Biomimetic Lipid Membrane Models on Aβ42 Aggregation

Baumann, K. N.; Sanguanini, M.; Rimon, O.; Sneideriene, G.; Greer, H.; Thacker, D.; Schneider, M. M.; Linse, S.; Knowles, T. P. J.; Vendruscolo, M.

10.1101/2022.04.16.488542 — biophysics — Posted on 2022-04-16

1644 USAT: a Bioinformatic Toolkit to Facilitate Interpretation and Comparative Visualization of Tandem Repeat Sequences

Wang, X.; Budowle, B.; Ge, J.

10.1101/2022.04.15.488513 — bioinformatics — Posted on 2022-04-16

1645 SATINN: An automated neural network-based classification of testicular sections allows for high-throughput histopathology of mouse mutants

Yang, R.; Stendahl, A.; Vigh-Conrad, K.; Held, M.; Lima, A.; Conrad, D.

10.1101/2022.04.16.488549 — bioinformatics — Posted on 2022-04-16

1646 Maps of high density microsatellites accumulation in human genome

Xia, Y.; Huang, H.; Liang, Y.; Li, D.; Chen, T.; Shi, R.; Pan, S.; Xu, F.; Peng, S.; Tan, Z.

10.1101/2022.04.16.487617 — bioinformatics — Posted on 2022-04-16

1647 A Deep SE(3)-Equivariant Model for Learning Inverse Protein Folding

McPartlon, m.; Lai, B.; Xu, J.

10.1101/2022.04.15.488492 — bioinformatics — Posted on 2022-04-16

1648 Defensiveness measurement in honey bees (Apis mellifera)and brain expression of associated genes after noxious stimulus

ACEVEDO-GONZALEZ, J. P.; Galindo-Cardona, A.; Fuenzalida-Uribe, N. L.; Ghezzi, A.; Giray, T.

10.1101/2022.04.15.488528 — animal behavior and cognition — Posted on 2022-04-16

1649 Reconstructing physical cell interaction networks from single-cell data using Neighbor-seq

Ghaddar, B.; De, S.

10.1101/2022.04.15.488517 — genomics — Posted on 2022-04-16

1650 Resource sharing leads to the emergence of division of labour

Kreider, J. J.; Janzen, T.; Bernadou, A.; Elsner, D.; Kramer, B. H.; Weissing, F. J.

10.1101/2022.04.15.488476 — evolutionary biology — Posted on 2022-04-16

1651 Genomic underpinnings of population persistence in Isle Royale moose

Kyriazis, C.; Beichman, A. C.; Brzeski, K. E.; Hoy, S. R.; Peterson, R. O.; Vucetich, J. A.; Vucetich, L. M.; Lohmueller, K. E.; Wayne, R. K.

10.1101/2022.04.15.488504 — evolutionary biology — Posted on 2022-04-16

1652 Phylogenomic patterns of divergence and gene flow detail the evolution of reinforcement and hybrid speciation in Phlox wildflowers

Garner, A. G.; Goulet-Scott, B. E.; Hopkins, R.

10.1101/2022.04.15.488502 — evolutionary biology — Posted on 2022-04-16

1653 A general framework for species-abundance distributions: linking traits and dispersal to explain commonness and rarity

Koffel, T.; Umemura, K.; Litchman, E.; Klausmeier, C. A.

10.1101/2022.04.15.488506 — ecology — Posted on 2022-04-16

1654 Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation

Alavattam, K. G.; Mitzelfelt, K. A.; Bonora, G.; Fields, P. A.; Yang, X.; Chiu, H. S.; Pabon, L.; Bertero, A.; Palpant, N. J.; Noble, W. S.; Murry, C. E.

10.1101/2022.04.15.488491 — developmental biology — Posted on 2022-04-16

1655 Cross-activation of the FGF, TGF-β and WNT pathways constrains BMP4-mediated induction of the Totipotent state in mouse embryonic stem cells.

Meharwade, T.; Joumier, L.; Parisotto, M.; Huynh, V.; Lummertz da Rocha, E.; Malleshaiah, M.

10.1101/2022.04.15.488509 — developmental biology — Posted on 2022-04-16

1656 RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release from Enteroendocrine Cells

Shepherd, A.; Feinstein, L.; Sabel, S.; Rastelli, D.; Mezhibovsky, E.; Matthews, L.; Muppirala, A.; Robinson, A.; Gershon, M. D.; Rao, M.

10.1101/2022.04.15.488514 — cell biology — Posted on 2022-04-16

1657 Cadmium is detrimental to Caenorhabditis elegans via anetwork involving circRNA, lncRNA and phosphorylatedprotein

Qu, Z.; Guo, P.; Zheng, S.; Yu, Z.; Liu, L.; Wang, P.; Zheng, F.; Lin, G.; Wang, P.; Liu, N.

10.1101/2022.04.16.486470 — molecular biology — Posted on 2022-04-16

1658 Microbiota of the pregnant mouse: characterization of the bacterial communities in the oral cavity, lung, intestine, and vagina through culture and DNA sequencing

Greenberg, J. M.; Romero, R.; Winters, A. D.; Galaz, J.; Garcia-Flores, V.; Arenas-Hernandez, M.; Panzer, J.; Shaffer, Z. D.; Kracht, D. J.; Gomez-Lopez, N.; Theis, K. R.

10.1101/2022.04.15.488507 — microbiology — Posted on 2022-04-16

1659 Crystal structure of the Rubella virus protease reveals a unique papain-like protease fold

Cheong, E. Z. K.; Quek, J. P.; Liu, X.; Li, C.; Chan, J. Y.; Liew, C. W.; Mu, Y.; Zheng, J.; Luo, D.

10.1101/2022.04.15.488536 — microbiology — Posted on 2022-04-16

1660 CbpD crystal structure adds intrigue to substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases

Dade, C.; Douzi, B.; Cambillau, C.; Ball, G.; Voulhoux, R.; Forest, K. T.

10.1101/2022.04.15.488525 — microbiology — Posted on 2022-04-16

1661 Estimation of cochlear frequency selectivity using a convolution model of forward-masked compound action potentials

Deloche, F.; Parida, S.; Sivaprakasam, A.; Heinz, M. G.

10.1101/2022.04.15.487700 — neuroscience — Posted on 2022-04-16

1662 Humoral signaling-mediated effects of unilateral brain injury: differences in the left-right sided afferent responses

Watanabe, H.; Kobikov, Y.; Sarkisyan, D.; Lavrov, I.; Schouenborg, J.; Zhang, M.; Bakalkin, G.

10.1101/2022.04.15.488460 — neuroscience — Posted on 2022-04-16

1663 Immediate neural network impact after the loss of a semantic hub

Kocsis, Z.; Jenison, R. L.; Cope, T. E.; Taylor, P. N.; Calmus, R. M.; McMurray, B.; Rhone, A. E.; Sarrett, M. E.; Kikuchi, Y.; Gander, P. E.; Berger, J. I.; Kovach, C. K.; Choi, I.; Greenlee, J. D.; Kawasaki, H.; Griffiths, T. D.; Howard, M. A.; Petkov, C. I.

10.1101/2022.04.15.488388 — neuroscience — Posted on 2022-04-16

1664 A revised calcium-dependent model of theta-burst transcranial magnetic stimulation

Ma, K.; Rothwell, J.; Goetz, S. M.

10.1101/2022.04.15.488478 — neuroscience — Posted on 2022-04-16

1665 Neural oscillations across olfactory regions encode odorant information in the teleost olfactory system

Olivares, J.; Orio, P.; Sadilek, V.; Schmachtenberg, O.; Canales-Johnson, A.

10.1101/2022.04.15.488302 — neuroscience — Posted on 2022-04-16

1666 Visual working memory recruits two functionally distinct alpha rhythms in posterior cortex

Rodriguez Larios, J.; ElShafei, A.; Wiehe, M.; Haegens, S.

10.1101/2022.04.15.488484 — neuroscience — Posted on 2022-04-16

1667 A python-based package for long-lasting video acquisition and semi-automated detection of convulsive seizures in rodents

DIAZ-ARCE, D.; GHOUMA, A.; SCALMANI, P.; MANTEGAZZA, M.; DUPRAT, F.

10.1101/2022.04.15.488472 — neuroscience — Posted on 2022-04-16

1668 Probing neuronal functions with precise and targeted laser ablation in the living cortex: reply

Cheng, Z.

10.1101/2022.04.15.488384 — neuroscience — Posted on 2022-04-16

1669 Single acoustic closed loop stimulation in mice to modulate hippocampo-thalamo-cortical activity and performance

Aksamaz, S.; Moelle, M.; Olubukola, A. E.; Bazhenov, M.; Marshall, L.

10.1101/2022.04.16.488547 — neuroscience — Posted on 2022-04-16

1670 Theory of spontaneous persistent activity and inactivity in vivo reveals differential cortico-entorhinal functional connectivity

Mehta, M. R.; Choudhary, K.; Berberich, S.; Hahn, T.

10.1101/2022.04.15.488496 — neuroscience — Posted on 2022-04-16

1671 Bayesian interpolation for power laws in neural data analysis

Davidovich, I. A.; Roudi, Y.

10.1101/2022.04.15.488481 — neuroscience — Posted on 2022-04-16

1672 Resilience to anxiety and anhedonia after predator scent stress is accompanied by increased nucleus accumbens mGlu5 in female rats

Blount, H. L.; Dee, J.; Wu, L.; Schwendt, M.; Knackstedt, L. A.

10.1101/2022.04.15.488499 — neuroscience — Posted on 2022-04-16

1673 Dopamine release at the time of a predicted aversive outcome causally controls the trajectory and expression of conditioned behavior

Kutlu, M. G.; Tat, J.; Zachry, J. E.; Calipari, E. S.

10.1101/2022.04.15.488530 — neuroscience — Posted on 2022-04-16

1674 Bone marrow haematopoietic stem cells influence liver homeostatic networks and cancer development after dietary intervention

10.1101/2022.04.16.488543 — systems biology — Posted on 2022-04-16

1675 The rhizodynamics robot: Automated imaging system for studying long-term dynamic root growth

McCaskey, E.; Taylor, I.; Pierce, C.; Ligon, J.; Aydin, E.; Hunner, C.; Carmichael, A.; Eserman, L.; Coffey, E. E. D.; Benfey, P. N.; Goldman, D. I.

10.1101/2022.04.15.488424 — plant biology — Posted on 2022-04-16

1676 Sustained morphine delivery suppresses bone formation and alters metabolic and circulating miRNA profiles in male C57BL/6J mice

Lelis Carvalho, A.; Brooks, D. J.; Barlow, D.; Langlais, A. L.; Morrill, B.; Houseknecht, K. L.; Bouxsein, M.; Lian, J. B.; King, T. E.; Farina, N.; Motyl, K. J.

10.1101/2022.04.15.484893 — physiology — Posted on 2022-04-16

1677 Heterotypic Endosomal Interactions Drive Emergent Early Endosomal Maturations

York, H. M.; Joshi, K.; Wright, C. S.; Moorthi, U. K.; Gandhi, H.; Patil, A.; Iyer-Biswas, S.; Arumugam, S.

10.1101/2022.04.15.488498 — biophysics — Posted on 2022-04-16

1678 Impact of sequencing technologies on long non-coding RNA computational identification

Chiquitto, A. G.; Silva, L. O. L.; Oliveira, L. S.; Domingues, D. S.; Paschoal, A. R.

10.1101/2022.04.15.488462 — bioinformatics — Posted on 2022-04-16

1679 Rye: genetic ancestry inference at biobank scale

Conley, A. B.; Rishishwar, L.; Ahmad, M.; Sharma, S.; Norris, E. T.; Jordan, I. K.; Marino-Ramirez, L.

10.1101/2022.04.15.488477 — bioinformatics — Posted on 2022-04-16

1680 rox: A statistical model for regression with missing values

Buyukozkan, M.; Benedetti, E.; Krumsiek, J.

10.1101/2022.04.15.488427 — bioinformatics — Posted on 2022-04-16

1681 Reproducible data integration and visualization of biological networks in R

Auer, F. J.; Chereda, H.; Perera-Bel, J.; Kramer, F.

10.1101/2022.04.15.488519 — bioinformatics — Posted on 2022-04-16

1682 A universal sequencing read interpreter

Kijima, Y.; Evans-Yamamoto, D.; Toyoshima, H.; Yachie, N.

10.1101/2022.04.16.488535 — bioinformatics — Posted on 2022-04-16

1683 Structure of the Dengue Virus RNA Promoter

Sun, Y.-T.; Varani, G.

10.1101/2022.04.15.488410 — biochemistry — Posted on 2022-04-16

1684 Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice

Vurusaner, B.; Thevkar-Nages, P.; Kaur, R.; Giannarelli, C.; Garabedian, M. J.; Fisher, E. A.

10.1101/2022.04.15.488480 — genetics — Posted on 2022-04-16

1685 Discovery of archaeal Fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins

Moi, D.; Nishio, S.; Li, X.; Valansi, C.; Langleib, M.; Brukman, N. G.; Flyak, K.; Dessimoz, C.; de Sanctis, D.; Tunyasuvunakool, K.; Jumper, J.; Grana, M.; Romero, H.; Aguilar, P. S.; Jovine, L.; Podbilewicz, B.

10.1101/2021.10.13.464100 — evolutionary biology — Posted on 2022-04-16

1686 Prescribed fire selects for a pyrophilous soil subcommunity in a northern California mixed conifer forest.

Fischer, M. S.; Patel, N. J.; de Lorimier, P. J.; Traxler, M. F.

10.1101/2022.04.15.488482 — ecology — Posted on 2022-04-16

1687 NaCl Triggers the Sessile-to-Motile Transition of Bacillus subtilis

Murugan, P. A.; Gupta, M. K.; Sankar, T. S.; Chandran, S.; Matheshwaran, S.

10.1101/2022.02.15.480532 — microbiology — Posted on 2022-04-16

1688 Combining Focal-ERG, Fluorescein Angiography, and SD-OCT for Retinal Neurovascular Analysis in a Mouse OIR-Model.

Mitton, K. p.; Deshpande, M.; Wong, S. C.; Guzman, A. E.; Cheng, M.; Dailey, W. A.; Schunemann, R.; Trese, M.; Drenser, K. A.

10.1101/2019.12.12.874271 — neuroscience — Posted on 2022-04-16

1689 Reconstitution and Expression of mcy Gene Cluster in The Model Cyanobacterium Synechococcus 7942 Reveals a Roll of MC-LR in Cell Division

Yanli, Z.; Chunling, X.; Hui, C.; Anqi, J.; Liang, Z.; Junli, Z.; Lixin, Z.; Qiang, W.

10.1101/2022.02.17.480855 — synthetic biology — Posted on 2022-04-16

1690 Hypoxia-inducible factor 1 signaling drives placental aging and can elicit inflammatory changes in uterine myocytes

Ciampa, E. J.; Flahardy, P.; Srinivasan, H.; Jacobs, C.; Tsai, L.; Karumanchi, S. A.; Parikh, S. M.

10.1101/2022.03.14.483784 — physiology — Posted on 2022-04-16

1691 Quercetin handles cellular oxidant / antioxidant systems and mitigates immunosenescence hallmarks in human PBMCs: an in vitro study

Bouamama, S.; Bouamama, A.

10.1101/2021.10.23.465570 — pharmacology and toxicology — Posted on 2022-04-16

1692 An exploratory study on the role of the stiffness of breast cancer cells in their detachment from spheroids and migration in 3D collagen matrices

Higgins, G.; Kim, J. E.; Ferruzzi, J.; Abdalrahman, T.; Franz, T.; Zaman, M. H.

10.1101/2021.01.21.427639 — cancer biology — Posted on 2022-04-16

1693 Differential genetic strategies of Burkholderia vietnamiensis and Paraburkholderia kururiensis for root colonization of Oryza sativa ssp. japonica and ssp. indica, as revealed by Tn-seq

Wallner, A.; Busset, N.; Lachat, J.; Guigard, L.; King, E.; Rimbault, I.; Mergaert, P.; Bena, G.; Moulin, L.

10.1101/2022.04.14.488431 — microbiology — Posted on 2022-04-16

1694 Context-dependent choice and evaluation in real-world consumer behavior

Otto, A. R.; Devine, S.; Schulz, E.; Bornstein, A. M.; Louie, K.

10.1101/2022.04.14.488290 — neuroscience — Posted on 2022-04-16

1695 Triglyceride lipolysis driven by glucose restriction triggers liquid-crystalline phase transitions and proteome remodeling of lipid droplets

Rogers, S.; Gui, L.; Kovalenko, A.; Zoni, V.; Carpentier, M.; Ramji, K.; Ben Mbarek, K.; Bacle, A.; Fuchs, P.; Campomanes, P.; Reetz, E.; Speer, N. O.; Reynolds, E.; Thiam, A. R.; Vanni, S.; Nicastro, D.; Henne, W. M.

10.1101/2022.04.15.488458 — cell biology — Posted on 2022-04-16

1696 Efficient plasmid transfer via natural competence in a synthetic microbial community

Cheng, Y.-Y.; Zhou, Z.; Papadopoulos, J. M.; Zuke, J. D.; Falbel, T.; Anantharaman, K.; Burton, B. M.; Venturelli, O. S.

10.1101/2020.10.19.342733 — systems biology — Posted on 2022-04-15

1697 The chemical Langevin equation for biochemical systems in dynamic environments

Ham, L.; Coomer, M.; Stumpf, M. P. H.

10.1101/2021.12.19.473404 — systems biology — Posted on 2022-04-15

1698 Mapping the Cell-Membrane Proteome to the Cancer Hallmarks

Lazar, I. M.; Karcini, A.; Haueis, J. R.

10.1101/2022.03.18.484818 — cancer biology — Posted on 2022-04-15

1699 Widespread redundancy in -omics profiles of cancer mutation states

Crawford, J.; Christensen, B. C.; Chikina, M.; Greene, C. S.

10.1101/2021.10.27.466140 — bioinformatics — Posted on 2022-04-15

1700 Sexual signals persist over deep time: ancient co-option of bioluminescence for courtship displays in cypridinid ostracods

Ellis, E. A.; Goodheart, J. A.; Hensley, N. M.; Gonzalez, V. L.; Reda, N. J.; Rivers, T. J.; Morin, J. G.; Torres, E.; Gerrish, G. A.; Oakley, T. H.

10.1101/2021.09.03.458903 — evolutionary biology — Posted on 2022-04-15

1701 Detection of ancestry-derived variants of modern Japanese revealed the formation process of regional gradations of the current Japanese archipelago population

Watanabe, Y.; Ohashi, J.

10.1101/2020.12.07.414037 — evolutionary biology — Posted on 2022-04-15

1702 Habitat preference influences response to changing agricultural landscapes in two long-horned bees.

Hirayama, G. S.; Ushimaru, A.

10.1101/2022.04.15.488450 — ecology — Posted on 2022-04-15

1703 A high-efficiency scar-free genome editing toolkit for Acinetobacter baumannii

de Dios, R.; Gadar, K.; McCarthy, R. R.

10.1101/2022.04.15.488490 — microbiology — Posted on 2022-04-15

1704 Efflux-linked Accelerated Evolution of Antibiotic Resistance at a Population Edge

Bhattacharyya, S.; Bhattacharyya, M.; Pfannenstiel, D. M.; Nandi, A. K.; Hwang, Y.; Ho, K.; Harshey, R. M.

10.1101/2022.04.01.486762 — microbiology — Posted on 2022-04-15

1705 General object-based features account for letter perception

Janini, D.; Hamblin, C.; Deza, A.; Konkle, T.

10.1101/2021.04.21.440772 — neuroscience — Posted on 2022-04-15

1706 High total water loss driven by low-fat diet in desert-adapted mice

Blumstein, D. M.; Colella, J. P.; Linder, E.; MacManes, M. D.

10.1101/2022.04.15.488461 — physiology — Posted on 2022-04-15

1707 Chloroplasts in plant cells show active glassy behavior under low light conditions

Schramma, N.; Perugachi Israëls, C.; Jalaal, M.

10.1101/2022.04.15.488438 — biophysics — Posted on 2022-04-15

1708 Loss-of-function, gain-of-function and dominant-negative mutations have profoundly different effects on protein structure: implications for variant effect prediction

Gerasimavicius, L.; Livesey, B. J.; Marsh, J. A.

10.1101/2021.10.23.465554 — bioinformatics — Posted on 2022-04-15

1709 Scan-Centric, Frequency-Based Method for Characterizing Peaks from Direct Injection Fourier transform Mass Spectrometry Experiments

Flight, R. M.; Mitchell, J. M.; Moseley, H. N. B.

10.1101/2022.04.14.488423 — bioinformatics — Posted on 2022-04-15

1710 BioAct: Biomedical Knowledge Base Construction using Active Learning

Wright, D.; Gentile, A. L.; Faux, N.; Beck, K. L.

10.1101/2022.04.14.488416 — bioinformatics — Posted on 2022-04-15

1711 Echtvar: Compressed variant representation for rapid annotation and filtering of SNPs and indels

Pedersen, B. S.; de Ridder, J.

10.1101/2022.04.15.488439 — bioinformatics — Posted on 2022-04-15

1712 Dcifer: an IBD-based method to calculate genetic distance between polyclonal infections

Gerlovina, I.; Gerlovin, B.; Rodriguez-Barraquer, I.; Greenhouse, B.

10.1101/2022.04.14.488406 — genetics — Posted on 2022-04-15

1713 Global drivers of obligate mycorrhizal symbionts diversification

Perez-Lamarque, B.; Opik, M.; Maliet, O.; Afonso Silva, A. C.; Selosse, M.-A.; Martos, F.; Morlon, H.

10.1101/2020.07.28.224790 — evolutionary biology — Posted on 2022-04-15

1714 Interpreting the pervasive observation of U-shaped Site Frequency Spectra

Freund, F.; Kerdoncuff, E.; Matuszewski, S.; Lapierre, M.; Hildebrandt, M.; Jensen, J. D.; Ferretti, L.; Lambert, A.; Sackton, T. B.; Achaz, G.

10.1101/2022.04.12.488084 — evolutionary biology — Posted on 2022-04-15

1715 Unilateral Perforant Path Transection Does Not Alter Lateral Entorhinal Cortical or Hippocampal CA3 Arc Expression

Cooper, T. L.; Thompson, J. J.; Turner, S. M.; Watson, C.; Lubke, K. N.; Logan, C. N.; Maurer, A. P.; Burke, S. N.

10.1101/2022.04.14.488420 — neuroscience — Posted on 2022-04-15

1716 Large-scale exploration of whole-brain structural connectivity in anorexia nervosa: alterations in the connectivity of frontal and subcortical networks

Lloyd, E. C.; Foerde, K. E.; Muratore, A. F.; Aw, N.; Semanek, D.; Steinglass, J. E.; Posner, J.

10.1101/2021.10.05.463197 — neuroscience — Posted on 2022-04-15

1717 Attentional rhythmic blink: Theta/Alpha balance in neural oscillations determines the rhythmicity in visual sampling

Kawashima, T.; Hayashi, M. J.; Amano, K.

10.1101/2022.04.15.488436 — neuroscience — Posted on 2022-04-15

1718 Stepwise origin and evolution of a transcriptional activator and repressor system integrating nutrient signaling in plants

Jamsheer K, M.; Gazara, R. K.; Jindal, S.; Kumar, M.

10.1101/2022.04.15.488190 — plant biology — Posted on 2022-04-15

1719 A combinatorial anticancer drug screen identifies off-target effects of epigenetic chemical probes

Barghout, S. H.; Mann, M. K.; Yu, Y.; Schimmer, A. D.; Schapira, M.; Arrowsmith, C. H.; Barsyte-Lovejoy, D.

10.1101/2022.04.14.488411 — pharmacology and toxicology — Posted on 2022-04-15

1720 Supervised spatial inference of dissociated single-cell data with SageNet

Heidari, E.; Lohoff, T.; Tyser, R. C. V.; Marioni, J.; Robinson, M. D.; Ghazanfar, S.

10.1101/2022.04.14.488419 — bioinformatics — Posted on 2022-04-15

1721 Validation of the first PGT-whole genome sequencing approach including mitochondrial variants

Xia, Y.; Chandramohan, D.; Chertman, W.; Bechor, E.; Maier, R.; Siddiqui, N.; Behr, B.; Schleede, J.

10.1101/2022.04.14.488421 — genomics — Posted on 2022-04-15

1722 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg fusion

Lu, Y.; Shimada, K.; Zhang, J.; Ogawa, Y.; Tang, S.; Shibuya, H.; Ikawa, M.

10.1101/2022.04.15.488448 — developmental biology — Posted on 2022-04-15

1723 The AKT Forkhead box O transcription factor axis regulates human cytomegalovirus replication

Zhang, H.; Domma, A. J.; Goodrum, F.; Moorman, N.; Kamil, J. P.

10.1101/2022.04.14.488435 — microbiology — Posted on 2022-04-15

1724 Snake Fungal Disease Caused by the Fungal Pathogen Ophidiomyces ophidiicola in Texas

Lizarraga, A.; Hart, L.; Nolen, M.; Williams, L. R.; Glavy, J. S.

10.1101/2022.04.14.488407 — microbiology — Posted on 2022-04-15

1725 Berberine Bridge Enzyme-Like Oligosaccharide Oxidases Act As Enzymatic Transducers Between Microbial Glycoside Hydrolases And Plant Peroxidases

Scortica, A.; Giovannoni, M.; Scafati, V.; Angelucci, F.; Cervone, F.; De Lorenzo, G.; Benedetti, M.; Mattei, B.

10.1101/2022.04.15.488465 — plant biology — Posted on 2022-04-15

1726 Functional testing of PI3K inhibitors stratifies responders to idelalisib and identifies treatment vulnerabilities in idelalisib-refractory/intolerant chronic lymphocytic leukemia

Yin, Y.; Athanasiadis, P.; Karlsen, L.; Urban, A.; Murali, I.; Fernandes, S. M.; Arribas, A. J.; Hilli, A. K.; Tasken, K.; Bertoni, F.; Mato, A. R.; Normant, E.; Brown, J. R.; Tjonnfjord, G. E.; Aittokallio, T.; Skanland, S. S.

10.1101/2022.04.14.488428 — cancer biology — Posted on 2022-04-15

1727 Ganglioside enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruption

Saha, J.; Bose, P.; Dhakal, S.; Ghosh, P.; Rangachari, V.

10.1101/2022.04.14.488413 — biophysics — Posted on 2022-04-15

1728 Compendium-wide analysis of P. aeruginosa core and accessory genes reveal more nuanced transcriptional patterns

Lee, A. J.; Doing, G.; Neff, S. L.; Reiter, T. E.; Hogan, D. A.; Greene, C. S.

10.1101/2022.04.14.488429 — bioinformatics — Posted on 2022-04-15

1729 Study on the interference of DicdsVg4 and DicdsVgR in egg formation in the ovary of Diaphorina citri (Kuwayama)

Li, H.; Wang, X.; Pan, B.; Zheng, X.; Lu, W.

10.1101/2022.04.15.488471 — biochemistry — Posted on 2022-04-15

1730 Comparative Analysis of rRNA removal methods for RNA-seq Differential Expression in Halophilic Archaea

Schmid, A. K.; Sakrikar, S.; Martinez-Pastor, M.; Rodriguez, D.

10.1101/2022.04.15.488396 — genomics — Posted on 2022-04-15

1731 A new chemotype of chemically tractable nonsteroidal estrogens based on a thienopyrimidine core.

Sammeta, V. R.; Norris, J. D.; Artham, S.; Torrice, C. D.; Byemerwa, J.; Joiner, C.; Fanning, S. W.; McDonnell, D. P.; Willson, T. M.

10.1101/2022.04.15.488344 — cell biology — Posted on 2022-04-15

1732 Light-inducible T cell engagers trigger, tune and shape the activation of primary T cells

Jaeger, M.; Anastasio, A.; Brustlein, S.; Vincentelli, R.; Durbesson, F.; Char, R.; Boussand, M.; Lechelon, M.; Arguello, R. J.; Marguet, D.; He, H.-T.; Lasserre, R.

10.1101/2022.04.15.488452 — immunology — Posted on 2022-04-15

1733 Parallel lipid-carried epitope pillars enhance stimulation of chimeric antigen receptor T cells

Tong, J.; Lai, H.; Wang, J.; Zhu, C.; Mai, X.; Zhou, D.

10.1101/2022.04.15.488352 — immunology — Posted on 2022-04-15

1734 The shape of aroma: measuring and modeling citrus oil gland distribution

Amezquita, E. J.; Quigley, M. Y.; Ophelders, T.; Seymour, D.; Munch, E.; Chitwood, D. H.

10.1101/2022.04.14.488418 — plant biology — Posted on 2022-04-15

1735 WNT5A-RHOA axis is a new vulnerability in small-cell lung cancer

Kim, K.-B.; Kim, D.-W.; Kim, Y.; Tang, J.; Kirk, N.; Gan, Y.; Fang, B.; Park, J.-I.; Zheng, Y.; Park, K.-S.

10.1101/2022.04.14.488408 — cancer biology — Posted on 2022-04-15

1736 Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data

Fisher, N. C.; Byrne, R.; Leslie, H.; Wood, C.; Legrini, A.; Cameron, A.; Ahmaderaghi, B.; Corry, S.; Malla, S.; Amirkhah, R.; McCooey, A.; Rogan, E.; Redmond, K.; Sakhnevych, S.; Domingo, E.; Jackson, J.; Loughrey, M.; Leedham, S.; Maughan, T.; Lawler, M.; Sansom, O. J.; Lamrock, F.; Koelzer, V. H.; Jamieson, N.; Dunne, P. D.

10.1101/2022.04.15.488354 — cancer biology — Posted on 2022-04-15

1737 3DPolyS-LE: an accessible simulation framework to model the interplay between chromatin and loop extrusion

Gitchev, T.; Zala, G.; Meister, P.; Jost, D.

10.1101/2022.04.15.488456 — biophysics — Posted on 2022-04-15

1738 Structural Characterization of L-Galactose Dehydrogenase: A Key Enzyme for Vitamin C Biosynthesis

Vargas, J. A.; Leonardo, D. A.; Pereira, H. D. M.; Lopes, A. R.; Rodriguez, H. N.; Cobos, M.; Marapara, J. L.; Castro, J. C.; Garratt, R. C.

10.1101/2022.04.15.488469 — biophysics — Posted on 2022-04-15

1739 Rare Monoclonal Antibody Discovery Based on Indirect Competitive Screening of Single Hapten-specific Rabbit Antibody Secreting Cell

Li, Y.; Li, P.; Ke, Y.; Yu, X.; Yu, W.; Wen, K.; Shen, J.; wang, z.

10.1101/2022.04.14.488422 — biochemistry — Posted on 2022-04-15

1740 Integrative chromatin domain annotation throughgraph embedding of Hi-C data

Shokraneh, N.; Arab, M.; Libbrecht, M. W.

10.1101/2022.04.14.488414 — genomics — Posted on 2022-04-15

1741 Performance Comparison Of Agilent New SureSelect All Exon v8 Probes With v7 Probes For Exome Sequencing

Belova, V.; Shmitko, A.; Pavlova, A.; Afasizhev, R.; Cheranev, V.; Tabanakova, A.; Ponikarovskaya, N.; Rebrikov, D.; Korostin, D.

10.1101/2022.04.15.488338 — genomics — Posted on 2022-04-15

1742 High genetic diversity in the pelagic deep-sea fauna of the Atacama Trench revealed by environmental DNA

Ramirez-Flandes, S.; Gonzalez, C.; Aldunate, M.; Poulain, J.; Wincker, P.; Glud, R.; Escribano, R.; Arnaud, S.; Ulloa, O.

10.1101/2022.04.14.488404 — ecology — Posted on 2022-04-15

1743 The E3/E4 ubiquitin ligase UFD-2 mediates negative feedback on Raf protein stability

Townley, R.; Deniaud, A.; Stacy, K. S.; Rodriguez Torres, C. S.; Cheraghi, F.; de la Cova, C. C.

10.1101/2022.04.14.488377 — developmental biology — Posted on 2022-04-15

1744 A landscape of differentiated biological processes involved in the initiation of sex differentiation in zebrafish

Ye, D.; Tu, Y.-X.; Wang, H.; He, M.; Wang, Y.; Chen, Z.; Chen, Z.-X.; Sun, Y.

10.1101/2022.04.14.488425 — developmental biology — Posted on 2022-04-15

1745 Infected I. scapularis nymphs maintained in prolonged questing under optimal environmental conditions for one year can transmit B. burgdorferi to uninfected hosts

Samanta, K.; Azevedo, J. F.; Nair, N.; Kundu, S.; Gomes-Solecki, M.

10.1101/2022.04.14.488430 — microbiology — Posted on 2022-04-15

1746 A Genome-Scale Metabolic Model of Marine Heterotroph Vibrio splendidus sp. 1A01

Iffland-Stettner, A.; Okano, H.; Gralka, M.; Guessous, G.; Amarnath, K.; Cordero, O. X.; Hwa, T.; Bonhoeffer, S.

10.1101/2022.04.15.488298 — microbiology — Posted on 2022-04-15

1747 Cooperative ectodomain interaction among TCRαβ, CD3γε, and CD3δε enhances TCR mechanotransduction

Yuan, Z.; Cong, P.; Natarajan, A.; Ge, C.; Travaglino, S.; Beesam, S.; Grazette, D.; Krogsgaard, M.; Zhu, C.

10.1101/2022.04.14.488403 — immunology — Posted on 2022-04-15

1748 Roseoflavin, a natural riboflavin analogue, possesses in vitro and in vivo antiplasmodial activity

Hemasa, A.; Mack, M.; Saliba, K. J.

10.1101/2022.04.14.488433 — pharmacology and toxicology — Posted on 2022-04-15

1749 BANKSY: A Spatial Omics Algorithm that Unifies Cell Type Clustering and Tissue Domain Segmentation

Singhal, V.; Chou, N.; Lee, J.; Liu, J.; Chock, W. K.; Lin, L.; Chang, Y.-C.; Teo, E.; Lee, H. K.; Chen, K. H.; Prabhakar, S.

10.1101/2022.04.14.488259 — bioinformatics — Posted on 2022-04-15

1750 Differential methylation, epigenetic clocks, and island-mainland divergence in an insectivorous small mammal

Cossette, M.-L.; Stewart, D. T.; Haghani, A.; Zoller, J. A.; Shafer, A. B. A.; Horvath, S.

10.1101/2022.04.14.488253 — genomics — Posted on 2022-04-15

1751 A bug's tale: revealing the history, biogeography and ecological patterns of 500 years of insect introductions

Estay, S. A.; Lopez, D. N.; Fuentes, E.; Ruiz, C.; Ide, S.

10.1101/2022.04.13.488245 — ecology — Posted on 2022-04-15

1752 Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo: Implications for theragnostics

Boorman, L.; Harris, S. S.; Shabir, O.; Lee, L.; Eyre, B.; Howarth, C.; Berwick, J.

10.1101/2022.04.14.488315 — neuroscience — Posted on 2022-04-15

1753 Systems Biology Approach of Understanding Insulin Resistance: Linkage between Type 2 Diabetes and Alzheimer's Disease

Lao, A. R.; Villasis, O. B. T.; Tan, D. S.; Mendoza, E.

10.1101/2022.04.13.463890 — systems biology — Posted on 2022-04-15

1754 Multi-Omics Regulatory Network Inference in the Presence of Missing Data

Henao, J. D.; Lauber, M.; Azevedo, M.; Grekova, A.; List, M.; Ogris, C.; Schubert, B.

10.1101/2022.04.14.488153 — systems biology — Posted on 2022-04-15

1755 The Main Themes and Experiences Shared with the Hashtag #BlackintheIvory: A Qualitative Analysis

Adewumi, T.; Delgado, P.; Carr, M.; Sowah, E.; Vassar, M.

10.1101/2022.04.13.488234 — scientific communication and education — Posted on 2022-04-15

1756 PvC3H29 interacts with and inhibits DNA binding of PvNAPs to finetune leaf senescence in switchgrass (Panicum virgatum)

Xie, Z.; Yu, G.; Lei, S.; Wang, H.; Xu, B.

10.1101/2022.04.14.488389 — plant biology — Posted on 2022-04-15

1757 Combined effects of 12-week yoga warm-up on athletic performance in male high school track and field athletes

Wei, D.

10.1101/2022.04.14.488191 — physiology — Posted on 2022-04-15

1758 Coupling and Heterogeneity Modulate Pacemaking Capability in Healthy and Diseased Two-Dimensional Sinoatrial Node Tissue Models

Campana, C.; Ricci, E.; Bartolucci, C.; Severi, S.; Sobie, E. A.

10.1101/2022.04.14.488275 — physiology — Posted on 2022-04-15

1759 How does target lesion selection affect RECIST? A computer simulation study

Bucho, T.; Tissier, R.; Bodalal, Z.; Nguyen-Kim, T. D. L.; Beets-Tan, R.; Trebeschi, S.

10.1101/2022.04.14.488203 — cancer biology — Posted on 2022-04-15

1760 resPAINT: Accelerating volumetric super-resolution localisation microscopy by active control of probe emission

Sanders, E.; Carr, A. R.; Bruggeman, E.; Koerbel, M.; Benaissa, S. I.; Donat, R.; Santos, A. M.; McColl, J.; O'Holleran, K.; Klenerman, D.; Davis, S. J.; Lee, S. F.; Ponjavic, A.

10.1101/2022.04.14.488333 — biophysics — Posted on 2022-04-15

1761 A spectral algorithm for polynomial-time graph isomorphism testing

O'Shea, R. J.

10.1101/2022.04.14.488296 — bioinformatics — Posted on 2022-04-15

1762 Optimal gap-affine alignment in O(s) space

Marco-Sola, S.; Eizenga, J. M.; Guarracino, A.; Paten, B.; Garrison, E.; Moreto, M.

10.1101/2022.04.14.488380 — bioinformatics — Posted on 2022-04-15

1763 Genetic admixture history and forensic characteristics of Tibeto-Burman-speaking Qiang people explored via the newly developed Y-STR panel and genome-wide SNP data

He, G.; Adnan, A.; Wang, M.; Al-Qahtani, W. S.; Safhi, F. A.; Yeh, H.-Y.; Hadi, S.; Wanag, C.-C.; Liu, C.; Yao, J.

10.1101/2022.04.13.488250 — genetics — Posted on 2022-04-15

1764 Impact of HIV infection and integrase strand transfer inhibitors-based treatment on gut virome

Villoslada-Blanco, P.; Perez-Matute, P.; Iniguez, M.; Recio-Fernandez, E.; Daan, J.; De Coninck, L.; Close, L.; Blanco-Navarrete, P.; Metola, L.; Ibarra, V.; Alba, J.; Matthijnssens, J.; Oteo, J. A.

10.1101/2022.04.14.488276 — microbiology — Posted on 2022-04-15

1765 Somatosensory Cortical Signature of Facial Nociception and Vibrotactile Touch Induced Analgesia

Wang, F.; Lu, J.; Chen, B.; Levy, M.; Xu, P.; Han, B.-X.; Takatoh, J.; Thompson, P.; He, Z.; Prevosto, V.

10.1101/2022.04.14.488349 — neuroscience — Posted on 2022-04-15

1766 3D pose estimation enables virtual head-fixation in freely moving rats

Schneider, A.; Zimmermann, C.; Alyahyay, M.; Steenbergen, F.; Brox, T.; Diester, I.

10.1101/2022.04.14.488303 — neuroscience — Posted on 2022-04-15

1767 Limited Evidence for a Triple Dissociation in the Medial Temporal Lobe: an fMRI Recognition Memory Replication Study

Van, J.; Nielsen, S. E.; Kirwan, B.

10.1101/2022.04.14.488400 — neuroscience — Posted on 2022-04-15

1768 Tumor necrosis factor α modulates excitatory and inhibitory neurotransmission in a concentration-dependent manner

Kleidonas, D.; Kirsch, M.; Andrieux, G.; Pfeifer, D.; Boerries, M.; Vlachos, A.

10.1101/2022.04.14.487444 — neuroscience — Posted on 2022-04-15

1769 Top-down modulation and cortical-AMG/HPC interaction in familiar face processing

Fan, X.; Guo, Q.; Zhang, X.; Fei, L.; He, S.; Weng, X.

10.1101/2022.04.14.488206 — neuroscience — Posted on 2022-04-15

1770 Effect of Chlonisol (2--1,3-propanediol) on Overall Survival in Laboratory Rodents with Intracranial Tumors: A Meta-analysis of Preclinical Studies

Murazov, I.; Stukov, A.; Zmitrichenko, I.

10.1101/2022.04.14.488286 — pharmacology and toxicology — Posted on 2022-04-15

1771 Proliferative advantage of specific aneuploid cells drives evolution of tumor karyotypes

Ban, I.; Tomasic, L.; Trakala, M.; Tolic, I. M.; Pavin, N.

10.1101/2022.04.14.488382 — biophysics — Posted on 2022-04-15

1772 A comprehensive study of mRNA and long noncoding RNAs in Indian Breast cancer patients using transcriptomics approach

Manjunath, M.; Nirgude, S.; Mhatre, A.; Vemuri, S. G.; Nataraj, M.; Thumsi, J. S.; Choudhary, B.

10.1101/2022.04.13.488261 — bioinformatics — Posted on 2022-04-15

1773 Neural network approach to somatic SNP calling in WGS samples without a matched control.

Vilov, S.; Heinig, M.

10.1101/2022.04.14.488223 — bioinformatics — Posted on 2022-04-15

1774 The Decision of the Optimal Rank of a Non-negative Matrix Factorization Model for Gene Expression Datasets Utilizing Unit Invariant Knee Method

Guven, E.

10.1101/2022.04.14.488288 — bioinformatics — Posted on 2022-04-15

1775 ScisorWiz: Visualizing Differential Isoform Expression in Single-Cell Long-Read Data

Stein, A. N.; Joglekar, A.; Poon, C.-L.; Tilgner, H.

10.1101/2022.04.14.488347 — bioinformatics — Posted on 2022-04-15

1776 Generative power of a protein language model trained on multiple sequence alignments

Sgarbossa, D.; Lupo, U.; Bitbol, A.-F.

10.1101/2022.04.14.488405 — bioinformatics — Posted on 2022-04-15

1777 MMR Deficiency Defines Distinct Molecular Subtype of Breast Cancer with Unique Proteomic Networks and Variable Clinical Significance

Hacking, S.; Chou, C.; Baykara, Y.; Wang, Y.; Uzun, A.; Uzun, E. D. G.

10.1101/2022.04.14.488341 — bioinformatics — Posted on 2022-04-15

1778 Digital data repository and automatic analysis framework for FDOPA PET neuroimaging

Nordio, G.; Easmin, R.; Giacomel, A.; Dipasquale, O.; Martins, D.; Williams, S.; Turkheimer, F. E.; Howes, O.; Jauhar, S.; Rogdaki, M.; McCutcheon, R.; Kaar, S.; Vano, L.; Rutigliano, G.; Angelescu, I.; Borgan, F.; D'Ambrosio, E.; Dahoun, T.; Kim, E.; Kim, S.; Bloomfield, M.; Egerton, A.; Demjaha, A.; Bonoldi, I.; Nosarti, C.; MacCabe, J. H.; McGuire, P.; Matthews, J.; Talbot, P.; Veronese, M.

10.1101/2022.04.14.488129 — bioengineering — Posted on 2022-04-15

1779 Covert attention to obstacles biases escapes via the Mauthner cell

Zwaka, H.; McGinnis, O. J.; Pflitsch, P.; Prabha, S.; Mansinghka, V.; Engert, F.; Bolton, A. D.

10.1101/2022.04.14.488363 — animal behavior and cognition — Posted on 2022-04-15

1780 Meiotic Nuclear Pore Complex Remodeling Provides Key Insights into Nuclear Basket Organization

King, G. A.; Wettstein, R.; Varberg, J. M.; Chetlapalli, K.; Walsh, M. E.; Gillet, L.; Hernandez-Armenta, C.; Beltrao, P.; Aebersold, R.; Jaspersen, S. L.; Matos, J.; Unal, E.

10.1101/2022.04.14.488376 — cell biology — Posted on 2022-04-15

1781 Kinesin-1 transports morphologically distinct intracellular virions during vaccinia infection

Xu, A.; Basant, A.; Schleich, S.; Newsome, T. P.; Way, M.

10.1101/2022.04.15.488437 — cell biology — Posted on 2022-04-15

1782 Arousal neurons that anticipate deviations in blood glucose.

Viskaitis, P.; Tesmer, A.; Karnani, M. M.; Arnold, M.; Donegan, D.; Bracey, E.; Peleg-Raibstein, D.; Burdakov, D.

10.1101/2022.04.14.488310 — neuroscience — Posted on 2022-04-15

1783 The tissue-specific chromatin accessibility landscape of Papaver somniferum

Xu, Y.; Jia, Y.; Wang, B.; Guo, L.; Guo, M.; Che, X.; Ye, K.

10.1101/2022.04.13.487984 — plant biology — Posted on 2022-04-15

1784 Hijacking of Cellular Functions by SARS-CoV-2. Permeabilization and Polarization of the Host Lipid Membrane by Viroporins.

Bignon, E.; Marazzi, M.; Monari, A.

10.1101/2022.04.14.488372 — biophysics — Posted on 2022-04-15

1785 Violation of the fluctuation-response relation from a linear model of hair bundle oscillations

Berger, F.; Hudspeth, A. J.

10.1101/2022.04.15.488459 — biophysics — Posted on 2022-04-15

1786 OrganoID: a versatile deep learning platform for tracking and analysis of single-organoid dynamics

Matthews, J. M.; Schuster, B.; Kashaf, S. S.; Liu, P.; Bilgic, M.; Rzhetsky, A.; Tay, S.

10.1101/2022.01.13.476248 — bioengineering — Posted on 2022-04-15

1787 Mentalizing in an economic games context is associated with enhanced activation and connectivity in left temporoparietal junction

Chang, L.-A.; Warns, L.; Armaos, K.; Ma de Sousa, A. Q.; Paauwe, F.; Scholz, C.; Engelmann, J. B.

10.1101/2022.02.12.480201 — neuroscience — Posted on 2022-04-15

1788 Mapping the integration of sensory information across fingers in human sensorimotor cortex

Arbuckle, S. A.; Pruszynski, J. A.; Diedrichsen, J.

10.1101/2021.07.07.451552 — neuroscience — Posted on 2022-04-15

1789 Inhibition of itch by neurokinin 1 receptor (Tacr1) -expressing ON cells in the rostral ventromedial medulla

Follansbee, T.; Domocos, D.; Nguyen, E.; Nguyen, A.; Bountouvas, A.; Velasquez, L.; Iodi-Carstens, M.; Takanami, K.; Ross, S. E.; Carstens, E.

10.1101/2021.04.06.438701 — neuroscience — Posted on 2022-04-15

1790 Coregistration of heading to visual cues in retrosplenial cortex

Sit, K. K.; Goard, M. J.

10.1101/2022.03.25.485865 — neuroscience — Posted on 2022-04-15

1791 Vaeda computationally annotates doublets in single-cell RNA sequencing data

Schriever, H.; Kostka, D.

10.1101/2022.04.15.488440 — bioinformatics — Posted on 2022-04-15

1792 Opponent learning with different representations in the cortico-basal ganglia circuits

Morita, K.; Shimomura, K.; Kawaguchi, Y.

10.1101/2021.10.29.466375 — neuroscience — Posted on 2022-04-15

1793 Extent of Molecular Chaperone Association Might Determine Fates of Membraneless Organelles during Aging in C. elegans

Mukherjee, P.; Panda, P.; Kasturi, P.

10.1101/2021.12.17.473198 — biochemistry — Posted on 2022-04-15

1794 The population genomics of increased virulence and antibiotic resistance in human commensal Escherichia coli over 30 years in France

Marin, J.; Clermont, O.; Royer, G.; Mercier-Darty, M.; Decousser, J.-W.; Tenaillon, O.; Denamur, E.; Blanquart, F.

10.1101/2021.06.24.449745 — genomics — Posted on 2022-04-15

1795 Mutualists construct the ecological conditions that trigger the transition from parasitism

Ledru, L.; Garnier, J.; Rohr, M.; Nous, C.; Ibanez, S.

10.1101/2021.08.18.456759 — evolutionary biology — Posted on 2022-04-15

1796 Integrated spatial models foster complementarity between monitoring programs in producing large-scale bottlenose dolphin indicators

Lauret, V.; Labach, H.; Turek, D.; Laran, S.; Gimenez, O.

10.1101/2021.02.01.429097 — ecology — Posted on 2022-04-15

1797 DetecDiv, a generalist deep-learning platform for automated cell division tracking and survival analysis

Aspert, T.; Hentsch, D.; Charvin, G.

10.1101/2021.10.05.463175 — cell biology — Posted on 2022-04-15

1798 Charting functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

Hanzl, A.; Casement, R.; Imrichova, H.; Hughes, S. J.; Barone, E.; Testa, A.; Bauer, S.; Wright, J.; Brand, M.; Ciulli, A.; Winter, G. E.

10.1101/2022.04.14.488316 — molecular biology — Posted on 2022-04-15

1799 Erythropoietin supplementation ameliorates the immunological and hematological deficiencies of lysinuric protein intolerance in mice

Giroud-Gerbetant, J.; Sotillo, F.; Couso, J.; Zorzano, A.; Sanchez, M.; Weiss, G.; Palacin, M.; Bodoy, S.

10.1101/2021.08.15.456393 — molecular biology — Posted on 2022-04-15

1800 Agrobacterium mediated transformation and deciphering SNPs in TaLr67 gene homeologs for gene editing in wheat.

Thiyagarajan, K.; Noguera, L. M.; Pacheco, M.; Govindan, V.; Vikram, P.

10.1101/2022.03.23.485492 — molecular biology — Posted on 2022-04-15

1801 Trait anxiety is associated with hidden state inference during aversive reversal learning

Zika, O.; Wiech, K.; Reinecke, A.; Browning, M.; Schuck, N. W.

10.1101/2022.04.01.483303 — neuroscience — Posted on 2022-04-15

1802 Cortical depth-dependent human fMRI of resting-state networks using EPIK

Pais-Roldan, P.; Yun, S. D.; Palomero-Gallagher, N.; Shah, J. N.

10.1101/2020.12.07.414144 — neuroscience — Posted on 2022-04-15

1803 Synthetic torpor triggers a neuroprotective and regulated mechanism in the rat brain, leading to the reversibility of Tau protein hyperphosphorylation.

Squarcio, F.; Hitrec, T.; Piscitiello, E.; Cerri, M.; Giovannini, C.; Martelli, D.; Occhinegro, A.; Taddei, L.; Tupone, D.; Amici, R.; Luppi, M.

10.1101/2022.03.25.485745 — neuroscience — Posted on 2022-04-15

1804 ISL1 is necessary for auditory neuron development and contributes towards tonotopic organization

Filova, I.; Pysanenko, K.; Tavakoli, M.; Vochyanova, S.; Dvorakova, M.; Bohuslavova, R.; Smolik, O.; Fabriciova, V.; Hrabalova, P.; Benesova, S.; Valihrach, L.; Cerny, J.; Yamoah, E. N.; Syka, J.; Fritzsch, B.; Pavlinkova, G.

10.1101/2021.09.03.458707 — neuroscience — Posted on 2022-04-15

1805 Experiencing surprise: the temporal dynamics of its impact on memory

Frank, D.; Kafkas, A.; Montaldi, D.

10.1101/2020.12.15.422817 — neuroscience — Posted on 2022-04-15

1806 The Temporal and Contextual Stability of Activity Levels in Hippocampal CA1 Cells

Hayashi, Y.; Kobayakawa, K.; Kobayakawa, R.

10.1101/2022.01.24.477445 — neuroscience — Posted on 2022-04-15

1807 Temporal change in chromatin accessibility predicts regulators of nodulation in Medicago truncatula

Knaack, S. A.; Conde, D.; Chakraborty, S.; Balmant, K. M.; Irving, T. B.; Gontijo Silva Maia, L.; Triozzi, P. M.; Dervinis, C.; Pereira, W. J.; Maeda, J.; Schmidt, H. W.; Ane, J.-M.; Kirst, M.; Roy, S.

10.1101/2021.08.07.455463 — plant biology — Posted on 2022-04-15

1808 Identifying targetable metabolic dependencies across colorectal cancer progression

10.1101/2022.03.23.485483 — cancer biology — Posted on 2022-04-15

1809 A multiscale lipid and cellular atlas of the human kidney

Neumann, E. K.; Patterson, N. H.; Tideman, L. E. M.; Migas, L. G.; Colley, M. E.; Farrow, M. A.; Allen, J. L.; Rivera, E. S.; Romer, C. E.; Yang, H.; Brewer, M.; Sharman, K.; Harris, R. C.; Fogo, A. B.; Gutierrez, D. B.; de Caestecker, M. P.; Caprioli, R. M.; Van de Plas, R.; Spraggins, J. M.

10.1101/2022.04.07.487155 — biochemistry — Posted on 2022-04-15

1810 A novel lineage of the Capra genus discovered in the Taurus Mountains of Turkey using ancient genomics.

Daly, K. G.; Arbuckle, B. S.; Rossi, C.; Mattiangeli, V.; Lawlor, P. A.; Mashkour, M.; Sauer, E.; Lesur, J.; Atici, L.; Erek, C. M.; Bradley, D. G.

10.1101/2022.04.08.487619 — genomics — Posted on 2022-04-15

1811 Evolution of selfish multicellularity: collective organisation of individual spatio-temporal regulatory strategies

Vroomans, R. M.; Colizzi, E. S.

10.1101/2022.04.08.487695 — evolutionary biology — Posted on 2022-04-15

1812 The recovery of biodiversity and species composition after agricultural abandonment across spatial scales

Ladouceur, E.; Isbell, F.; Clark, A. T.; Harpole, W. S.; Reich, P. B.; Tilman, G. D.; Chase, J. M.

10.1101/2022.04.14.488351 — ecology — Posted on 2022-04-15

1813 Improving the validity of neuroimaging decoding tests of invariant and configural neural representation

Soto, F. A.; Narasiwodejar, S.

10.1101/2020.02.27.967505 — neuroscience — Posted on 2022-04-15

1814 Hormones do not make the mole-rat: no steroid hormone signatures of subordinate behavioral phenotypes

Faykoo-Martinez, M.; Toor, I.; Edwards, P. D.; Boonstra, R.; Holmes, M. M.

10.1101/2022.04.14.487730 — animal behavior and cognition — Posted on 2022-04-15

1815 What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons

Cole, A. B.; Montgomery, K.; Bale, T. L.; Thompson, S. M.

10.1101/2022.04.14.488387 — neuroscience — Posted on 2022-04-15

1816 Context-dependent sensory modulation underlies Bayesian vocal sequence perception

Sainburg, T.; McPherson, T. S.; Arneodo, E. M.; Rudraraju, S.; Turvey, M.; Thielman, B.; Tostado Marcos, P.; Thielk, M.; Gentner, T. Q.

10.1101/2022.04.14.488412 — neuroscience — Posted on 2022-04-15

1817 Pneumococcal Evasion of Antibiotics via Metabolic Adaptation During Infection

Dao, T.; Echlin, H.; McKnight, A.; Marr, E.; Junker, J.; Jia, Q.; Hayden, R.; Rosch, J.

10.1101/2022.04.14.488313 — microbiology — Posted on 2022-04-15

1818 Rapid microglial phenotype changes modulate neuronal networks and sharp wave-ripple activity in acute slice preparations

Denes, A.; Berki, P.; Cserep, C.; Posfai, B.; Szabadits, E.; Kornyei, Z.; Kellermayer, A.; Nyerges, M.

10.1101/2022.04.12.487998 — neuroscience — Posted on 2022-04-15

1819 RADGENNETS: DEEP LEARNING-BASED RADIOGENOMICS MODEL FOR GENE MUTATION PREDICTION IN LUNG CANCER

Tripathi, S.; Augustin, A. I.; Moyer, E. J.; Zavalny, A.; Dheer, S.; Sukumaran, R.; Schwartz, D.; Gorski, B.; Dako, F.; Kim, E.

10.1101/2022.04.13.488208 — cancer biology — Posted on 2022-04-15

1820 Co-expression of recombinant human collagen α1(III) chain with viral prolyl 4-Hydroxylase in P. pastoris GS115

Fang, J. Y.; Ma, Z.; Liu, D. Y.; Wang, Z. G.; Zheng, S.; Wu, H. Y.; Xia, P. J.; Chen, X.; Yang, R.; Hao, L. L.

10.1101/2022.04.13.488258 — biochemistry — Posted on 2022-04-15

1821 Rescue of Escherichia coli auxotrophy by de novo small proteins

Babina, A.; Surkov, S.; Ye, W.; Jerlström-Hultqvist, J.; Larsson, M.; Holmqvist, E.; Jemth, P.; Andersson, D.; Knopp, M.

10.1101/2022.04.13.488163 — evolutionary biology — Posted on 2022-04-15

1822 Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nano-architecture in flight muscles

Schnorrer, F.; Schueder, F.; Mangeol, P.; Chan, E. H.; Rees, R.; Schünemann, J.; Jungmann, R.; Görlich, D.

10.1101/2022.04.14.488306 — developmental biology — Posted on 2022-04-15

1823 A nanobody toolbox to investigate localisation and dynamics of Drosophila titins

Schnorrer, F.; Loreau, V.; Rees, R.; Chan, E. H.; Taxer, W.; Gregor, K.; Mussil, B.; Pitaval, C.; Luis, N. M.; Mangeol, P.; Görlich, D.

10.1101/2022.04.13.488177 — developmental biology — Posted on 2022-04-15

1824 A genetic model for in vivo proximity labeling of the mammalian secretome

Yang, R.; Meyer, A. S.; Droujinine, I. A.; Udeshi, N. D.; Hu, Y.; Guo, J.; McMahon, J. A.; Carey, D. K.; Xu, C.; Fang, Q.; Sha, J.; Qin, S.; Rocco, D.; Wohlschlegel, J.; Ting, A. Y.; Carr, S. A.; Perrimon, N.; McMahon, A. P.

10.1101/2022.04.13.488228 — cell biology — Posted on 2022-04-15

1825 Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3

Porte, R.; Silva-Gomes, R.; Theroude, C.; Parente, R.; Asgari, F.; Sironi, M.; Pasqualini, F.; Valentino, S.; Asselta, R.; Recordati, C.; Doni, A.; Inforzato, A.; Rodriguez-Gallego, C.; Obando, I.; Colino, E.; Bottazzi, B.; Mantovani, A.

10.1101/2022.04.14.488329 — immunology — Posted on 2022-04-15

1826 Identification of microRNAs in the Lyme disease vector Ixodes scapularis

Kumar, D.; Downs, L.; Embers, M. E.; Flynt, A. S.; Karim, S.

10.1101/2022.04.14.488330 — molecular biology — Posted on 2022-04-14

1827 Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination

Zhao, H.; Hartono, S. R.; de Vera, K. M. F.; Yu, Z.; Zhao, T.; Satchi, K.; Sanz, L.; Chedin, F.; Barlow, J.

10.1101/2021.10.18.464857 — immunology — Posted on 2022-04-14

1828 Spatial exploration of immune cell heterogeneity in skin functional scar-less wound regeneration model at single-cell resolution

YANG, Y.; CHU, C.; Hu, C.; WANG, C.; Qu, Y.; Man, Y.

10.1101/2022.03.24.485669 — immunology — Posted on 2022-04-14

1829 Lateral Orbitofrontal Cortex and Basolateral Amygdala Regulate Sensitivity to Delayed Punishment during Decision-making

Liley, A. E.; Gabriel, D. B. K.; Simon, N. W.

10.1101/2022.04.13.488205 — neuroscience — Posted on 2022-04-14

1830 Distinct cortical responses to Auditory Statistics: pre-attentive discriminations based on local and global representations

Berto, M.; Ricciardi, E.; Pietrini, P.; Bottari, D.

10.1101/2022.03.17.484757 — neuroscience — Posted on 2022-04-14

1831 Nuclear inhibitor of protein phosphatase 1 (NIPP1) regulates CNS tau phosphorylation and myelination during development

McKee, C.; Shrager, P.; Mazumder, A.; Ganguly, A.; Mayer, A.; Foley, K.; Ward, N.; Youngman, M.; Hou, H.; Xia, H.

10.1101/2022.04.02.486849 — neuroscience — Posted on 2022-04-14

1832 PhysiBoSS 2.0: a sustainable integration of stochastic Boolean and agent-based modelling frameworks

Ponce-de-Leon, M.; Montagud, A.; Noel, V.; Pradas, G.; Meert, A.; Barillot, E.; Calzone, L.; Valencia, A.

10.1101/2022.01.06.468363 — systems biology — Posted on 2022-04-14

1833 Network Inference from Perturbation Time Course Data

Sarmah, D.; Smith, G. R.; Bouhaddou, M.; Stern, A. D.; Erskine, J.; Birtwistle, M.

10.1101/341008 — systems biology — Posted on 2022-04-14

1834 Group-walk, a rigorous approach to group-wise false discovery rate analysis by target-decoy competition

Freestone, J.; Short, T.; Noble, W. S.; Keich, U.

10.1101/2022.01.30.478144 — bioinformatics — Posted on 2022-04-14

1835 Targeted Sequencing of Alzheimers Disease Genes in Gujarat Cohort

Budhbhatti, U.; Patel, A.; Joshi, C.; Chauhan, A.; Bhatt, D.; Parmar, C.; Damani, V.

10.1101/2022.04.14.488366 — genomics — Posted on 2022-04-14

1836 A shared brain system forming confidence judgment across cognitive domains

Rouault, M.; Lebreton, M.; Pessiglione, M.

10.1101/2021.09.17.460809 — neuroscience — Posted on 2022-04-14

1837 Mapping Consistent, Reproducible, and Transcriptionally Relevant Functional Connectome Hubs of the Human Brain

Xu, Z.; Xia, M.; Wang, X.; Liao, X.; Zhao, T.; He, Y.

10.1101/2021.11.29.470494 — neuroscience — Posted on 2022-04-14

1838 Multiscale model of primary motor cortex circuits predicts in vivo cell type-specific, behavioral state-dependent dynamics

Dura-Bernal, S.; Neymotin, S. A.; Suter, B. A.; Dacre, J.; Schiemann, J.; Duguid, I.; Shepherd, G. M. G.; Lytton, W. W.

10.1101/2022.02.03.479040 — neuroscience — Posted on 2022-04-14

1839 Probability-based mechanisms in biological networks with parameter uncertainty

Ortega, O. O.; Ozen, M.; Wilson, B. A.; Pino, J. C.; Irvin, M. W.; Ildefonso, G. V.; Garbett, S. P.; Lopez, C. F.

10.1101/2021.01.26.428266 — systems biology — Posted on 2022-04-14

1840 The Arabidopsis Framework Model version 2 predicts the organism-level effects of circadian clock gene mis-regulation

Chew, Y. H.; Seaton, D. D.; Mengin, V.; Flis, A.; Mugford, S. T.; George, G. M.; Moulin, M.; Hume, A.; Zeeman, S. C.; Fitzpatrick, T. B.; Smith, A. M.; Stitt, M.; Millar, A. J.

10.1101/105437 — plant biology — Posted on 2022-04-14

1841 Transcription disrupts DNA-scaffolded bacteriophage repressor complexes

Lu, Y.; Voros, Z.; Borjas, G.; Hendrickson, C.; Shearwin, K. E.; Dunlap, D.; Finzi, L.

10.1101/2021.10.29.466366 — biophysics — Posted on 2022-04-14

1842 Structural determinants of Acid-sensing ion channel potentiation by single chain lipids

Klipp, R. C.; Bankston, J. R.

10.1101/2021.06.25.449979 — biophysics — Posted on 2022-04-14

1843 TranSyT, an innovative framework for identifying transport systems

Lagoa, D.; Faria, J. L.; Liu, F.; Cunha, E.; Henry, C.; Dias, O.

10.1101/2021.04.29.441738 — bioinformatics — Posted on 2022-04-14

1844 merlin v4.0: an updated platform for the reconstruction of high-quality genome-scale metabolic models

Capela, J.; Lagoa, D.; Rodrigues, R.; Cunha, E.; Cruz, F.; Barbosa, A.; Bastos, J.; Lima, D.; Ferreira, E. C.; Rocha, M.; Dias, O.

10.1101/2021.02.24.432752 — bioinformatics — Posted on 2022-04-14

1845 SPICEMIX: Integrative single-cell spatial modeling of cell identity

Chidester, B.; Zhou, T.; Alam, S.; Ma, J.

10.1101/2020.11.29.383067 — bioinformatics — Posted on 2022-04-14

1846 Simultaneous quantification of ankle, muscle, and tendon impedance in humans

Jakubowski, K. L.; Ludvig, D.; Bujnowski, D.; Lee, S.; Perreault, E. J.

10.1101/2021.12.08.471793 — bioengineering — Posted on 2022-04-14

1847 Depletion of Sun1/2 induces heterochromatin accrual in mesenchymal stem cells during adipogenesis

Goelzer, M.; Howard, S.; Zavala, A.; Conway, D. E.; Rubin, J.; van Wijnen, A. J.; Uzer, G.

10.1101/2022.02.15.480528 — bioengineering — Posted on 2022-04-14

1848 A novel lineage of the Capra genus discovered in the Taurus Mountains of Turkey using ancient genomics.

Daly, K. G.; Arbuckle, B. S.; Rossi, C.; Mattiangeli, V.; Lawlor, P. A.; Mashkour, M.; Sauer, E.; Lesur, J.; Atici, L.; Erek, C. M.; Bradley, D. G.

10.1101/2022.04.08.487619 — genomics — Posted on 2022-04-14

1849 Predicting Dog Phenotypes from Genotypes

Bartusiak, E. R.; Barrabes, M.; Rymbekova, A.; Gimbernat-Mayol, J.; Lopez, C.; Barberis, L.; Mas Montserrat, D.; Giro-i-Nieto, X.; Ioannidis, A. G.

10.1101/2022.04.13.488108 — genomics — Posted on 2022-04-14

1850 Theoretical Analysis of Principal Components in an Umbrella Model of Intraspecific Evolution

Estavoyer, M.; Francois, O.

10.1101/2021.11.28.470252 — evolutionary biology — Posted on 2022-04-14

1851 Pervasive selection pressure in wild and domestic pigs

Leno-Colorado, J.; Guirao-Rico, S.; Perez-Enciso, M.; Ramos-Onsins, S. E.

10.1101/2020.09.09.289439 — evolutionary biology — Posted on 2022-04-14

1852 Evolutionary traits of Tick-borne encephalitis virus: Pervasive non-coding RNA structure conservation and molecular epidemiology

Kutschera, L. S.; Wolfinger, M. T.

10.1101/2021.12.16.473019 — evolutionary biology — Posted on 2022-04-14

1853 Size matters, so does condition: the use of a body condition index reveals the costs and benefits of structural body size in an insect.

Zanchi, C.; Moret, Y.; Gillingham, M. A.

10.1101/774893 — ecology — Posted on 2022-04-14

1854 Mechanisms Underlying WNT-mediated Priming of Human Embryonic Stem Cells

Yoney, A.; Bai, L.; Brivanlou, A. H.; Siggia, E. D.

10.1101/2021.05.01.442278 — developmental biology — Posted on 2022-04-14

1855 The evolution of a counter-defense mechanism in a virus constrains its host range

Srikant, S.; Guegler, C. K.; Laub, M. T.

10.1101/2022.04.14.488369 — microbiology — Posted on 2022-04-14

1856 Whole-brain modeling explains the context-dependent effects of cholinergic neuromodulation

Coronel-Oliveros, C.; Giessing, C.; Medel, V.; Cofre, R.; Orio, P.

10.1101/2022.03.21.485145 — neuroscience — Posted on 2022-04-14

1857 Adaptive immunity is required for durable responses to alectinib in murine models of EML4-ALK lung cancer

Kleczko, E. K.; Hinz, T. K.; Nguyen, T. T.; Gurule, N. J.; Navarro, A.; Le, A. T.; Johnson, A. M.; Kwak, J.; Polhac, D. I.; Clambey, E. T.; Weiser-Evans, M. C.; Patil, T.; Schenk, E. L.; Heasley, L. E.; Nemenoff, R. A.

10.1101/2022.04.14.488385 — cancer biology — Posted on 2022-04-14

1858 p66Shc is an apoptotic rheostat whose targeted ROS inhibition improves MI outcomes

Haslem, L.; Hays, J. M.; Schmitz, H.; Matsuzaki, S.; Sjoelund, V.; Byrum, S. D.; Humphries, K. M. A.; Frazer, J. K.; Demeler, B.; Benbrook, D. M.; Tierney, R. M.; Duggan, K. D.; Hays, F. A.

10.1101/2022.04.14.487897 — biochemistry — Posted on 2022-04-14

1859 AlphaFold2 can predict structural and phenotypic effects of single mutations

Mcbride, J. M.; Reinharz, V.; Polev, K.; Grzybowski, B. A.; Tlusty, T.

10.1101/2022.04.14.488301 — biochemistry — Posted on 2022-04-14

1860 High-throughput proteomics of nanogram-scale samples with Zeno SWATH DIA

Wang, Z.; Muelleder, M.; Batruch, I.; Chelur, A.; Textoris-Taube, K.; Schwecke, T.; Hartl, J.; Causon, J.; Castro-Perez, J.; Demichev, V.; Tate, S.; Ralser, M.

10.1101/2022.04.14.488299 — biochemistry — Posted on 2022-04-14

1861 Genomic surveillance unfolds the dynamics of SARS-CoV-2 transmission and divergence in Bangladesh over the past two years

Shishir, T. A.; Jannat, T.; Naser, I. B.

10.1101/2022.04.13.488264 — genomics — Posted on 2022-04-14

1862 Investigating CRISPR spacer targets and their impact on genomic diversification of Streptococcus mutans

Walker, A. R.; Shields, R. C.

10.1101/2022.04.14.488371 — genomics — Posted on 2022-04-14

1863 Cell division drives DNA methylation loss in late-replicating domains in primary human cells

Endicott, J. L.; Nolte, P. A.; Shen, H.; Laird, P. W.

10.1101/2022.04.14.485664 — genomics — Posted on 2022-04-14

1864 Human genomic DNA is widely interspersed with i-motif structures

Pena Martinez, C. D.; Zeraati, M.; Rouet, R.; Mazigi, O.; Gloss, B.; Chan, C.-L.; Bryan, T. M.; Smith, N. M.; Dinger, M. E.; Kummerfeld, S. K.; Christ, D.

10.1101/2022.04.14.488274 — genetics — Posted on 2022-04-14

1865 Metabolic compatibility and the rarity of prokaryote endosymbioses

Libby, E.; Kempes, C. P.; Okie, J.

10.1101/2022.04.14.488272 — evolutionary biology — Posted on 2022-04-14

1866 Incomplete activation of developmentally required genes Alyref1 and Gabpb1 leads to preimplantation arrest in cloned mouse embryos

Ihashi, S.; Hamanaka, M.; Kaji, M.; Mori, M.; Imasato, Y.; Nakamura, M.; Anzai, M.; Matsumoto, K.; Ikawa, M.; Miyamoto, K.

10.1101/2022.04.14.488417 — developmental biology — Posted on 2022-04-14

1867 Infection with Listeria monocytogenes alters the placental transcriptome and eicosanome

Conner, K. N.; Holman, D.; Lydic, T.; Hardy, J. W.

10.1101/2022.04.14.488381 — developmental biology — Posted on 2022-04-14

1868 DMT1 bridges endosomes and mitochondria to modulate mitochondrial iron translocation

Barra, J.; Crosbourne, I.; Wang, L.; Bossardi-Ramos, R.; Jourd'heuil, F.; Nelson, I.; Adam, A. P.; Corr, D. T.; Jourd'heuil, D.; Barroso, M.

10.1101/2022.04.14.488402 — cell biology — Posted on 2022-04-14

1869 Cell wound repair requires the coordinated action of linear and branched actin nucleation factors

Hui, J.; Nakamura, M.; Dubrulle, J.; Parkhurst, S. M.

10.1101/2022.04.14.488397 — cell biology — Posted on 2022-04-14

1870 Single Nucleus Sequencing of Human Colon Visceral Smooth Muscle Cells, PDGFRα Cells, and Interstitial Cells of Cajal

Schneider, S.; Hashmi, S. K.; Thrasher, A. J.; Kothakapa, D. R.; Wright, C. M.; Heuckeroth, R. O.

10.1101/2022.04.14.488224 — cell biology — Posted on 2022-04-14

1871 Control of UV damage repair during S phase via Dyrk1A-dependent regulation of cyclin D1/p21waf1cip1 stability

Belanger, F.; Roussel, C.; Sawchyn, C.; Gezzar-Dandashi, S.; Mallette, F. A.; Wurtele, H.; Drobetsky, E. A.

10.1101/2022.04.14.488378 — molecular biology — Posted on 2022-04-14

1872 RNA localization mechanisms transcend cell morphology

Goering, R.; Arora, A.; Taliaferro, M.

10.1101/2022.04.14.488401 — molecular biology — Posted on 2022-04-14

1873 A congenital hydrocephalus causing mutation in Trim71 results in stem cell differentiation defects through inhibiting Lsd1 mRNA translation

Liu, Q.; Novak, M. K.; Pepin, R.; Maschhoff, K.; Chen, X.; Zhang, S.; Hu, W.

10.1101/2022.04.14.488304 — molecular biology — Posted on 2022-04-14

1874 Specific targeting of plasmids with Argonaute enables genome editing

Esyunina, D.; Okhtienko, A.; Olina, A.; Prostova, M.; Aravin, A. A.; Kulbachiskiy, A.

10.1101/2022.04.14.488398 — molecular biology — Posted on 2022-04-14

1875 Charting functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

Hanzl, A.; Casement, R.; Imrichova, H.; Hughes, S. J.; Barone, E.; Testa, A.; Bauer, S.; Wright, J.; Brand, M.; Ciulli, A. E.; Winter, G. E.

10.1101/2022.04.14.488316 — molecular biology — Posted on 2022-04-14

1876 TNFα-induced metabolic reprogramming drives an intrinsic anti-viral state

Ciesla, J.; Moreno, I.; Munger, J.

10.1101/2022.04.14.488171 — microbiology — Posted on 2022-04-14

1877 Architecture of the biofilm-associated archaic CupE pilus from Pseudomonas aeruginosa

Boehning, J.; Dobbelstein, A.; Sulkowski, N.; Eilers, K.; von Kugelgen, A.; Tarafder, A. K.; Alva, V.; Filloux, A.; Bharat, T. A. M.

10.1101/2022.04.14.488289 — microbiology — Posted on 2022-04-14

1878 Antigen and IL-33 synergistically promote chromatin accessibility at the regulatory regions of pro-inflammatory genes of human skin mast cells

Gao, J.; Li, Y.; Guan, X.; Mohammed, Z.; Gomez, G.; Hui, Y.; Oskeritzian, C. A.; Huang, H.

10.1101/2022.04.14.488379 — immunology — Posted on 2022-04-14

1879 Dysfunctional glymphatic system with disrupted aquaporin-4 expression pattern on astrocytes causes bacterial product accumulation in the CSF during pneumococcal meningitis

Generoso, J. S.; Thorsdottir, S.; Collodel, A.; Dominguini, D.; Santo, R. R. E.; Petronilho, F.; Barichello, T.; Iovino, F.

10.1101/2022.04.14.488283 — neuroscience — Posted on 2022-04-14

1880 Whole-body metabolic modelling predicts isoleucine dependency of SARS-CoV-2 replication

Thiele, I.; Fleming, R. M.

10.1101/2022.04.13.488249 — systems biology — Posted on 2022-04-14

1881 Biochemical characterization of Pectin Methylesterase Inhibitor 3 from Arabidopsis thaliana

Xu, F.; Gonneau, M.; Faucher, E.; Habrylo, O.; LEFEBVRE, V.; Domon, J. M.; Martin, M.; Senechal, F.; Peaucelle, A.; PELLOUX, J.; Hofte, H.

10.1101/2022.04.14.488319 — plant biology — Posted on 2022-04-14

1882 This is GlycoQL

Hayes, C.; Daponte, V.; Mariethoz, J.; LISACEK, F.

10.1101/2022.04.14.488348 — bioinformatics — Posted on 2022-04-14

1883 Redox-controlled structural reorganization and flavin strain within the ribonucleotide reductase R2b-NrdI complex monitored by serial femtosecond crystallography

John, J.; Aurelius, O.; Srinivas, V.; Kim, I.-S.; Bhowmick, A.; Simon, P. S.; Dasgupta, M.; Pham, C.; Gul, S.; Sutherlin, K. D.; Aller, P.; Butryn, A.; Orville, A. M.; Cheah, M. H.; Owada, S.; Tono, K.; Fuller, F. D.; Batyuk, A.; Brewster, A. S.; Sauter, N. K.; Yachandra, V. K.; Yano, J.; Kern, J.; Lebrette, H.; Hogbom, M.

10.1101/2022.04.14.488295 — biochemistry — Posted on 2022-04-14

1884 Asymmetric survival in single-cell lineages of cyanobacteria in response to photodamage

Tay, J. W.; Cameron, J. C.

10.1101/2022.04.14.488368 — biochemistry — Posted on 2022-04-14

1885 Linkage mapping and genome annotation give novel insights into gene family expansions and regional recombination rate variation in the painted lady (Vanessa cardui) butterfly

Shipilina, D.; Näsvall, K.; Höök, L.; Vila, R.; Talavera, G.; Backström, N.

10.1101/2022.04.14.488360 — genomics — Posted on 2022-04-14

1886 Sustained plumage divergence despite weak genomic differentiation and broad sympatry in sister species of Australian woodswallows (Artamus spp.)

Penalba, J. V.; Peters, J. L.; Joseph, L.

10.1101/2022.04.14.488308 — evolutionary biology — Posted on 2022-04-14

1887 Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Fornicata

Santos, R.; Astvaldsson, A.; Pipaliya, S. V.; Zumthor, J. P.; Dacks, J. B.; Svard, S.; Hehl, A. B.; Faso, C.

10.1101/2022.04.14.488357 — cell biology — Posted on 2022-04-14

1888 Mutual inhibition of airway epithelial responses supports viral and fungal co-pathogenesis during coinfection

Dancer, P.; Pickard, A.; Potocka, W.; Earle, K.; Fortune-Grant, R.; Kadler, K.; Bertuzzi, M.; Gago, S.

10.1101/2022.04.13.488236 — microbiology — Posted on 2022-04-14

1889 The sphingolipid inhibitor myriocin increases susceptibility of Candida auris to amphotericin B

Stieber, H.; Junghanns, L.; Wilhelm, H.; Batliner, M.; Aldejohann, A. M.; Kurzai, O.; Martin, R.

10.1101/2022.04.14.488279 — microbiology — Posted on 2022-04-14

1890 The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages

Herman, K. D.; Wright, C. G.; Marriott, H. M.; McCaughran, S. C.; Collins, M.; Renshaw, S. A.; Prince, L. R.

10.1101/2022.04.14.488364 — immunology — Posted on 2022-04-14

1891 Reward Bases: Instantaneous reward revaluation with temporal difference learning

Millidge, B.; Walton, M.; Bogacz, R.

10.1101/2022.04.14.488361 — neuroscience — Posted on 2022-04-14

1892 Generative Moment Matching Networks for Genotype Simulation

Perera, M.; Mas Montserrat, D.; Barrabes, M.; Geleta, M.; Giro-i-Nieto, X.; Ioannidis, A. G.

10.1101/2022.04.14.488350 — bioinformatics — Posted on 2022-04-14

1893 ProFeatMap: a customizable tool for 2D feature representation of protein sets

Bich, G.; Monsellier, E.; Trave, G.; Nomine, Y.

10.1101/2022.04.14.488325 — bioinformatics — Posted on 2022-04-14

1894 A silk-based platform to stabilize phenylalanine ammonia-lyase (PAL) for orally administered enzyme replacement therapy

d'Amone, L.; Trivedi, V. D.; Nair, N. U.; Omenetto, F. G.

10.1101/2022.04.14.488340 — bioengineering — Posted on 2022-04-14

1895 Quantitative Cell Proteomic Atlas: Pathway-scale targeted mass spectrometry for high-resolution functional profiling of cell signaling

Cifani, P.; Kentsis, A.

10.1101/2022.04.14.488331 — biochemistry — Posted on 2022-04-14

1896 Quantitative analysis of C. elegans transcripts by Nanopore direct-cDNA sequencing reveals terminal hairpins in non trans-spliced mRNAs

Bernard, F.; Dargere, D.; Rechavi, O.; Dupuy, D.

10.1101/2022.04.14.488332 — genomics — Posted on 2022-04-14

1897 A butterfly pan-genome reveals a large amount of structural variation underlies the evolution of chromatin accessibility

Ruggieri, A. A.; Livraghi, L.; Lewis, J. J.; Evans, E.; Cicconardi, F.; Hebberecht, L.; Montgomery, S. H.; Ghezzi, A.; Rodriguez-Martinez, J. A.; Jiggins, C. D.; McMillan, W. O.; Counterman, B. A.; Papa, R.; Van Belleghem, S. M.

10.1101/2022.04.14.488334 — genomics — Posted on 2022-04-14

1898 A Physiology Clock for Human Aging

Libert, S.; Chekholko, A.; Kenyon, C.

10.1101/2022.04.14.488358 — genetics — Posted on 2022-04-14

1899 HER2 expression defines unique requirements for flotillin and c-Src for EGFR signaling

Abousawan, J.; Orofiamma, L. A.; Fairn, G. D.; Antonescu, C. N.

10.1101/2022.04.14.488353 — cell biology — Posted on 2022-04-14

1900 Parallel recruitment pathways contribute to synaptonemal complex assembly during mammalian meiosis

Crichton, J. H.; Dunce, J. M.; Baarends, W. M.; Davies, O. R.; Adams, I. R.

10.1101/2022.04.14.488335 — cell biology — Posted on 2022-04-14

1901 A mitochondrial iron-sensing pathway regulated by DELE1

Sekine, Y.; Houston, R.; Fessler, E.; Jae, L. T.; Narendra, D. P.; Sekine, S.

10.1101/2022.04.14.488327 — cell biology — Posted on 2022-04-14

1902 Identification of microRNAs in the Lyme disease vector Ixodes scapularis

Kumar, D.; Downs, L.; Embers, M. E.; Flynt, A. S.; Karim, S. S.

10.1101/2022.04.14.488330 — molecular biology — Posted on 2022-04-14

1903 Acute administration of a dopamine D2/D3 receptor agonist alters behavioral and neural parameters in adult zebrafish

Nabinger, D. D.; Altenhofen, S.; Buatois, A.; Facciol, A.; Peixoto, J. V.; Kuhl da Silva, J. M.; Rübensam, G.; Gerlai, R.; Bonan, C. D.

10.1101/2022.04.14.488337 — neuroscience — Posted on 2022-04-14

1904 Relation is an option for processing context information

Yamada, K. D.; Baladram, M. S.; Lin, F.

10.1101/2022.04.14.488336 — neuroscience — Posted on 2022-04-14

1905 Predictable fluctuations in excitatory synaptic strength due to natural variation in presynaptic firing rate

Ren, N.; Wei, G.; Ghanbari, A.; Stevenson, I. H.

10.1101/2022.04.14.488362 — neuroscience — Posted on 2022-04-14

1906 Immunogenic cell death in mice expressing caspase-resistant ROCK1 is not replicated by ROCK inhibitors

Naylor, G.; Julian, L.; Watson-Bryce, S.; Mullin, M.; Nibbs, R. J.; Olson, M. F.

10.1101/2022.04.14.488346 — cancer biology — Posted on 2022-04-14

1907 CanSig: Discovering de novo shared transcriptional programs in single cancer cells

Yates, J.; Barkmann, F.; Czyz, P.; Glettig, M.; Lohmann, F.; Von Der Horst, R.; Saquand, E.; Volken, N.; Kraft, A.; Boeva, V.

10.1101/2022.04.14.488324 — bioinformatics — Posted on 2022-04-14

1908 LRT: T Cell Trajectory Inference by Integrative Analysis of Single Cell TCR-seq and RNA-seq data

Xie, J.; Xin, G.; Ma, Q.; Chung, D.

10.1101/2022.04.14.488320 — bioinformatics — Posted on 2022-04-14

1909 DAPC of genotype data only requires the first k - 1 PC axes for k populations

Thia, J. A.

10.1101/2022.04.13.488270 — genetics — Posted on 2022-04-14

1910 Outer Membrane Vesicle Mediated Multidrug Resistance Gene Transfer in Avibacterium Paragallinarum

xu, j.; mei, c.; Zhi, Y.; Liang, Z. x.; Zhang, X.; Wang, H. j.

10.1101/2022.04.13.488265 — molecular biology — Posted on 2022-04-14

1911 Acute appendicitis manifests as two microbiome state types with oral pathogens influencing severity

Blohs, M.; Mahnert, A.; Brunnader, K.; Flucher, C.; Castellani, C.; Till, H.; Singer, G.; Moissl-Eichinger, C.

10.1101/2022.04.13.488268 — microbiology — Posted on 2022-04-14

1912 Tauroursodeoxycholic acid inhibits Clostridioides difficile toxin induced apoptosis

Pike, C. M.; Tam, J.; Melnyk, R.; Theriot, C. M.

10.1101/2022.04.13.488266 — microbiology — Posted on 2022-04-14

1913 Glossiness perception and its pupillary response

Tamura, H.; Nakauchi, S.; Minami, T.

10.1101/2022.04.13.488254 — neuroscience — Posted on 2022-04-14

1914 The Computational Neuroanatomy of Predictive Dynamics of Pain Perception

Ishikawa, R.; Izawa, J.

10.1101/2022.04.13.488260 — neuroscience — Posted on 2022-04-14

1915 The tissue-specific chromatin accessibility landscape of Papaver somniferum

Xu, Y.; Jia, Y.; Wang, B.; Guo, L.; Guo, M.; Che, X.; Ye, K.

10.1101/2022.04.13.487984 — plant biology — Posted on 2022-04-14

1916 Comparative genomics in Orobanchaceae provides insight into the origin and evolution of plant parasitism

Xu, Y.; Zhang, J.; Ma, C.; Lei, Y.; Shen, G.; Jin, J.-J.; Eaton, D. A. R.; Wu, J.

10.1101/2022.04.13.488246 — plant biology — Posted on 2022-04-14

1917 Enhanced expression of 4-Cl-IAA and 6-Cl-IAA by touch stimulus for rapid and differential growths of the Madeira vine

Ma, M.-H.; Batsaikhan, E.; Wu, C.-M.; Lee, H.-H.; Luo, C.-I.; Chen, N.-J.; Chung, J.-D.; Chien, C.-T.; Tsai, Y.-H.; Li, W.-H.

10.1101/2022.04.13.488269 — plant biology — Posted on 2022-04-14

1918 Assignment of structural transitions during mechanical unwrapping of nucleosomes and their disassembly products

Diaz-Celis, C. D.; Canari-Chumpitaz, C.; Sosa, R. P.; Castillo, J. P.; Zhang, M.; Cheng, E.; Chen, A.; Vien, M.; Kim, J.; Onoa, B.; Bustamante, C. J.

10.1101/2022.04.13.488252 — biophysics — Posted on 2022-04-14

1919 A joint learning approach for genomic prediction in polyploid grasses

Aono, A. H.; Ferreira, R. C. U.; Moraes, A. d. C. L.; Lara, L. A. d. C.; Pimenta, R. J. G.; Costa, E. A.; Pinto, L. R.; Landell, M. G. d. A.; Santos, M. F.; Jank, L.; Barrios, S. C. L.; do Valle, C. B.; Chiari, L.; Garcia, A. A. F.; Kuroshu, R. M.; Lorena, A. C.; Gorjanc, G.; de Souza, A. P.

10.1101/2022.04.13.488210 — bioinformatics — Posted on 2022-04-14

1920 Gene Expression Changes in Therapeutic Ultrasound-Treated Human Chronic Wound Tissue

Ngo, O.; Abedin, Z.; DiMaria-Ghalili, R.; Weingarten, M. S.; Neidrauer, M.; Lewin, P. A.; Spiller, K. L.

10.1101/2022.04.13.488030 — bioengineering — Posted on 2022-04-14

1921 Local recruitment of DNA repair proteins enhances CRISPR-ssODN-HDR editing

Jillette, N.; Zhu, J. J.; Cheng, A. W.

10.1101/2022.04.13.488255 — bioengineering — Posted on 2022-04-14

1922 SARS-CoV-2 Omicron BA.1 variant infection of human colon epithelial cells

Antia, A.; Alvarado, D. M.; Zeng, Q.; Davis, D. L.; Ciorba, M. A.; Ding, S.

10.1101/2022.04.13.487939 — microbiology — Posted on 2022-04-14

1923 ModA phasevarions regulate adherence of non-typeable Haemophilus influenzae to the host airway in a tissue-specific manner

Garai, P.; Atack, J. M.; Wills, B. M.; Jennings, M. P.; Bakaletz, L. O.; Brockman, K.

10.1101/2022.04.13.488267 — microbiology — Posted on 2022-04-14

1924 Isolation, purification, and characterisation of a phage tail-like bacteriocin from the insect pathogenic bacterium Brevibacillus laterosporus

Babar, T. K.; Glare, T.; Hampton, J.; Hurst, M. R. H.; Narciso, J.

10.1101/2022.04.13.488263 — microbiology — Posted on 2022-04-14

1925 A Third Somatomotor Representation in the Human Cerebellum

Saadon-Grosman, N.; Angeli, P. A.; DiNicola, L. M.; Buckner, R. L.

10.1101/2022.04.13.488247 — neuroscience — Posted on 2022-04-14

1926 Multisite Test-Retest Reliability and Compatibility of Brain Metrics derived from FreeSurfer Versions 7.1, 6.0, and 5.3

Haddad, E.; Pizzagalli, F.; Zhu, A. H.; Bhatt, R. R.; Islam, T.; Ba Gari, I.; Dixon, D.; Thomopoulos, S. I.; Thompson, P. M.; Jahanshad, N.

10.1101/2022.04.13.488251 — neuroscience — Posted on 2022-04-14

1927 Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells

Kim, T.; Min, K. I.; Yang, J.-S.; Kim, J. W.; Cho, J.; Kim, Y. H.; Lee, J. S.; Kim, Y. T.; Kim, K.-C.; Kim, J. Y.; Na, K. J.; Lee, J.-Y.; Ju, Y. S.

10.1101/2022.04.13.486321 — microbiology — Posted on 2022-04-14

1928 Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

Pastorio, C.; Zech, F.; Noettger, S.; Jung, C.; Jacob, T.; Sparrer, K. M. J.; Kirchhoff, F.

10.1101/2022.04.13.488221 — microbiology — Posted on 2022-04-14

1929 Epitope Mapping of SARS-CoV-2 Spike Protein Reveals Distinguishable Antibody Binding Activity of Vaccinated and Infected Individuals.

Felbinger, N.; Trudil, D. P.; Loomis, L. L.; Ascione, R.; Siragusa, G. R.; Haba, S.; Mucci, A.; Claycomb, M.; Snowberger, S.; Luke, B.; Tsang, S.; Francesconi, S. C.

10.1101/2022.04.13.487697 — immunology — Posted on 2022-04-14

1930 Free fatty acid receptor 4 (FFAR4) regulates cardiac oxylipin balance to promote inflammation resolution in a model of heart failure preserved ejection fraction secondary to metabolic syndrome

Zhang, N.; Murphy, K. A.; Harsch, B.; Zhang, M.; Gyberg, D. J.; Wagner, B. M.; Mendelson, J.; Patterson, M. T.; Orchard, D. A.; Healy, C. L.; Williams, J. W.; Shearer, G. C.; O'Connell, T.

10.1101/2022.04.13.488227 — physiology — Posted on 2022-04-14

1931 Complete mutational mapping of a GTPase switch in vivo reveals novel allosteric regulation

Mathy, C. J. P.; Mishra, P.; Flynn, J. M.; Perica, T.; Mavor, D.; Bolon, D. N. A.; Kortemme, T.

10.1101/2022.04.13.488230 — biophysics — Posted on 2022-04-14

1932 Structural basis of mammalian Complex IV inhibition by steroids

Di Trani, J.; Moe, A.; Riepl, D.; Saura, P.; Kaila, V. R. I.; Brzezinski, P.; Rubinstein, J. L.

10.1101/2022.04.13.488242 — biophysics — Posted on 2022-04-14

1933 Classifying enthalpy-neutral DNA strand displacement cascades: trading off desired and undesired signal propagation

Wang, B.; Thachuk, C.; Soloveichik, D.

10.1101/2022.04.13.488226 — bioengineering — Posted on 2022-04-14

1934 In-cell penetration selection-mass spectrometry produces noncanonical peptides for antisense delivery

Schissel, C. K.; Farquhar, C. E.; Loas, A.; Malmberg, A. B.; Pentelute, B. L.

10.1101/2022.04.13.488231 — bioengineering — Posted on 2022-04-14

1935 3' RNA sequencing does not increase power or reduce costs for gene expression analysis

Crow, T. M.; Gill, J.; Whitehead, A. M.; Runcie, D. E.

10.1101/2022.04.13.488225 — genomics — Posted on 2022-04-14

1936 Individual-based quantitative temporal beta-diversity: Novel indices for assessing community compositional shifts accounting for changes in the properties of individuals

Nakadai, R.

10.1101/2022.04.13.488244 — ecology — Posted on 2022-04-14

1937 The role of neuropeptides in regulating ecdysis and reproduction in the hemimetabolous insect Rhodnius prolixus

Sterkel, M.; Volonte, M.; Albornoz, M. G.; Wulff, J. P.; del Huerto Sanchez, M.; Teran, P. M.; Ajmat, M. T.; Ons, S.

10.1101/2022.04.13.488237 — developmental biology — Posted on 2022-04-14

1938 Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury

Romaus-Sanjurjo, D.; Saikia, J. M.; Kim, H. J.; Tsai, K. M.; Le, G. Q.; Zheng, B.

10.1101/2022.04.14.488293 — neuroscience — Posted on 2022-04-14

Chen, A. A.; Weinstein, S. M.; Adebimpe, A.; Gur, R. C.; Gur, R. E.; Merikangas, K. R.; Satterthwaite, T. D.; Shinohara, R. T.; Shou, H.

10.1101/2022.04.13.488201 — neuroscience — Posted on 2022-04-14

1940 Fast, Efficient, and Accurate Neuro-Imaging Denoising via Deep Learning

Chaudhary, S.; Moon, S.; Lu, H.

10.1101/2022.04.13.488233 — neuroscience — Posted on 2022-04-14

1941 Lossless end-to-end transport of small molecules through micron-length DNA nanochannels

Li, Y.; Maffeo, C.; Joshi, H.; Aksimentiev, A.; Menard, B.; Schulman, R.

10.1101/2022.04.13.488239 — synthetic biology — Posted on 2022-04-14

1942 A hybrid unsupervised approach for accurate short read clustering and barcoded sample demultiplexing in nanopore sequencing

Han, R.; Qi, J.; Xue, Y.; Li, L.; Gao, X.; Li, G.

10.1101/2022.04.13.488186 — bioinformatics — Posted on 2022-04-14

1943 Human blood plasma proteins modeling and binding affinities with Δ9-tetrahydrocannabinol active metabolites: In silico approach

Rathod, S. B.; Soni, J. C.; Verma, P.; Rawat, Y.; Periwal, N.; Arora, P.; Sood, V.; Mansuri, M. F.

10.1101/2022.04.13.488197 — bioinformatics — Posted on 2022-04-14

1944 A structural database of chain-chain and domain-domain interfaces of proteins

Sen, N.; Madhusudhan, M. S.

10.1101/2022.04.13.488238 — bioinformatics — Posted on 2022-04-14

1945 Evolution and co-evolution of the suck behaviour, a postcopulatory female resistance trait that manipulates received ejaculate

Singh, P.; Brand, J. N.; Schärer, L.

10.1101/2022.04.13.485945 — evolutionary biology — Posted on 2022-04-14

1946 Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production

Lee, S. H.; Liu, X.; Jimenez-Morales, D.; Rinaudo, P.

10.1101/2022.04.13.488204 — developmental biology — Posted on 2022-04-14

1947 Schizophrenia-derived hiPSC brain microvascular endothelial cells show impairments in angiogenesis and blood-brain barrier function

Casas, B. S.; Vitoria, G.; Prieto, C. P.; Casas, M.; Chacon, C.; Uhrig, M.; Ezquer, F.; Ezquer, M.; Rehen, S. K.; Palma, V.

10.1101/2022.04.14.488066 — cell biology — Posted on 2022-04-14

1948 Lateral Orbitofrontal Cortex and Basolateral Amygdala Regulate Sensitivity to Delayed Punishment during Decision-making

Liley, A. E.; Gabriel, D. B. K.; Simon, N. W.

10.1101/2022.04.13.488205 — neuroscience — Posted on 2022-04-14

1949 Self-avoidance alone does not explain the function of Dscam1 in mushroom body axonal wiring

Dong, H.; Guo, P.; Zhang, J.; Wu, L.; Fu, Y.; Li, L.; Zhu, Y.; Du, Y.; Shi, J.; Zhang, S.; Li, G.; Xu, B.; Bian, L.; Zhu, X.; You, W.; Yang, X.; Huang, J.; Yongfeng, J.

10.1101/2022.04.14.488273 — neuroscience — Posted on 2022-04-14

1950 Synaptic wiring motifs in posterior parietal cortex support decision-making

Kuan, A. T.; Bondanelli, G.; Driscoll, L. N.; Han, J.; Kim, M.; Hildebrand, D. G. C.; Graham, B. J.; Thomas, L. A.; Panzeri, S.; Harvey, C. D.; Lee, W.-C. A.

10.1101/2022.04.13.488176 — neuroscience — Posted on 2022-04-14

1951 Cis mutagenesis in vivo reveals extensive noncanonical functions of Dscam1 isoforms in neuronal wiring

Zhang, S.; Yang, X.; Dong, H.; Xu, B.; Wu, L.; Zhang, J.; Li, G.; Guo, P.; Li, L.; Fu, Y.; Du, Y.; Zhu, Y.; Shi, F.; Huang, J.; He, H.; Jin, Y.

10.1101/2022.04.14.488281 — neuroscience — Posted on 2022-04-14

1952 Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food

Eliason, N. L.; Martin, L.; Low, M. J.; Sharpe, A. L.

10.1101/2022.04.13.488209 — neuroscience — Posted on 2022-04-14

1953 Effect of Positive Allosteric Modulation and Orthosteric Agonism of Dopamine D2 Receptors on Respiration in Mouse Models of Rett Syndrome

Maletz, S. N.; Reid, B. T.; Baekey, D. M.; Whitaker-Fornek, J. R.; Bateman, J. T.; Bissonnette, J. M.; Levitt, E. S.

10.1101/2022.04.13.488220 — pharmacology and toxicology — Posted on 2022-04-14

1954 Transcriptomics based prediction of survival and response to therapy in malignant mesothelioma

Nair, N. U.; Jiang, Q.; Wei, J. S.; Misra, V. A.; Morrow, B.; Kesserwan, C.; Hermida, L. C.; Lee, J. S.; Mian, I.; Zhang, J.; Lebensohn, A.; Sengupta, M.; Khan, J.; Ruppin, E.; Hassan, R.

10.1101/2022.04.13.488207 — cancer biology — Posted on 2022-04-14

1955 CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer

Tsujino, T.; Takai, T.; Hinohara, K.; Gui, F.; Tsutsumi, T.; Bai, X.; Miao, C.; Feng, C.; Gui, B.; Sztupinszki, S.; Simoneau, A.; Xie, N.; Fazli, L.; Dong, X.; Azuma, H.; Choudhury, A. D.; Mouw, K. W.; Szallasi, Z.; Zou, L.; Kibel, A. S.; Jia, L.

10.1101/2022.04.13.488115 — cancer biology — Posted on 2022-04-14

1956 Tumor cell-intrinsic HFE drives glioblastoma growth

Troike, K. M.; Silver, D. J.; Ghosh, P. K.; Mulkearns-Hubert, E. E.; Hubert, C. G.; Connor, J. R.; Fox, P. L.; Kristensen, B. W.; Lathia, J.

10.1101/2022.04.13.487917 — cancer biology — Posted on 2022-04-14

1957 Improved MALDI-TOF MS based antimicrobial resistance prediction through hierarchical stratification

Weis, C.; Rieck, B. A.; Balzer, S.; Cuenod, A.; Egli, A.; Borgwardt, K.

10.1101/2022.04.13.488198 — bioinformatics — Posted on 2022-04-14

1958 Heterogeneity in the gene regulatory landscape of leiomyosarcoma.

Belova, T.; Biondi, N.; Hsieh, P.-H.; Chudasama, P.; Kuijjer, M. L.

10.1101/2022.04.13.488196 — bioinformatics — Posted on 2022-04-14

1959 CellDrift: Inferring Perturbation Responses in Temporally-Sampled Single Cell Data

Jin, K.; Schnell, D.; Li, G.; Salomonis, N.; Prasath, S.; Szczesniak, R.; Aronow, B. J.

10.1101/2022.04.13.488194 — bioinformatics — Posted on 2022-04-14

1960 A Novel and Prevalent Pathway in Microbial Selenium Metabolism

Kayrouz, C. M.; Seyedsayamdost, M. R.

10.1101/2022.04.13.486033 — biochemistry — Posted on 2022-04-14

1961 Predicting Dog Phenotypes from Genotypes

Bartusiak, E. R.; Barrabes, M.; Rymbekova, A.; Gimbernat-Mayol, J.; Lopez, C.; Barberis, L.; Mas Montserrat, D.; Giro-i-Nieto, X.; Ioannidis, A. G.

10.1101/2022.04.13.488108 — genomics — Posted on 2022-04-14

1962 The broad shell colour variation in common cockle (Cerastoderma edule) from Northeast Atlantic relies on a major QTL revealed by GWAS using a new high-density genetic map

Hermida, M.; Robledo, D.; Diaz, S.; Costas, D.; Bruzos, A. L.; Blanco, A.; Martinez, P.

10.1101/2022.04.13.488192 — genomics — Posted on 2022-04-14

1963 Fast Kernel-based Association Testing of non-linear genetic effects for Biobank-scale data

Fu, B.; Pazokitoroudi, A.; Sudarshan, M.; Subramanian, L.; Sankararaman, S.

10.1101/2022.04.13.488214 — genetics — Posted on 2022-04-14

1964 Coding of reward uncertainty and probability by orexin neurons

Bracey, E.; Grujic, N.; Peleg-Raibstein, D.; Burdakov, D.

10.1101/2022.04.13.488195 — neuroscience — Posted on 2022-04-14

1965 Spinosaurids as 'subaqueous foragers' undermined by selective sampling and problematic statistical inference

Myhrvold, N. P.; Sereno, P. C.; Baumgart, S. L.; Formoso, K. K.; Vidal, D.; Fish, F. E.; Henderson, D. M.

10.1101/2022.04.13.487781 — paleontology — Posted on 2022-04-14

1966 Tree diversity effects on productivity depend on mycorrhizae and life strategies in a temperate forest experiment

Dietrich, P.; Ferlian, O.; Huang, Y.; Luo, S.; Quosh, J.; Eisenhauer, N.

10.1101/2022.04.13.488178 — ecology — Posted on 2022-04-14

1967 Oxytocinergic modulation of stress-associated amygdala-hippocampus pathways in humans is mediated by serotonergic mechanisms

Lan, C.; Liu, C.; Li, K.; Zhao, Z.; Ma, Y.; Yang, J.; Scheele, D.; Yao, S.; Kendrick, K.; Becker, B.

10.1101/2021.11.06.467580 — neuroscience — Posted on 2022-04-14

1968 Patching Science - amending the literature through version control

Kane, A.; Amin, B.

10.1101/2022.04.13.487348 — scientific communication and education — Posted on 2022-04-14

1969 The potyviral protein 6K2 from Turnip mosaic virus increases plant resilience to drought

Prakash, V.; Nihranz, C. T.; Casteel, C. L.

10.1101/2022.04.04.487062 — plant biology — Posted on 2022-04-14

1970 Spatiotemporal patterning enabled by gene regulatory networks

Roy, U.; Singh, D.; Vincent, N.; Haritas, C. K.; Jolly, M. K.

10.1101/2022.04.13.488152 — biophysics — Posted on 2022-04-14

1971 Onlinemeta: A Web Serve For Meta-Analysis Based On R-shiny

Yi, Y.; Lin, A.; Zhou, C.; Zhang, J.; Wang, S.; Luo, P.

10.1101/2022.04.13.488126 — bioinformatics — Posted on 2022-04-14

1972 Automated detection of sow posture changes with millimeter-wave radars and deep learning

Dore, A.; Lihoreau, M.; Baily, J.; Billon, Y.; Bompa, J.; Ricard, E.; Henry, D.; Canario, L.; Aubert, H.

10.1101/2022.04.13.488188 — animal behavior and cognition — Posted on 2022-04-14

1973 Dimensionality of genomic information and its impact on GWA and variant selection: a simulation study

Jang, S.; Tsuruta, S.; Leite, N. G.; Misztal, I.; Lourenco, D.

10.1101/2022.04.13.488175 — genomics — Posted on 2022-04-14

1974 Larger but younger fish when growth compensates for higher mortality in heated ecosystem

Lindmark, M.; Karlsson, M.; Gardmark, A.

10.1101/2022.04.13.488128 — ecology — Posted on 2022-04-14

1975 Changes in species interactions amplify the temperature dependence of microbial community respiration

Garcia, F. C.; Clegg, T.; Barrios-O'Neill, D.; Warfield, R.; Pawar, S.; Yvon-Durocher, G.

10.1101/2021.04.15.439947 — ecology — Posted on 2022-04-14

1976 xia2.multiplex: a multi-crystal data analysis pipeline

Gildea, R. J.; Beilsten-Edmands, J.; Axford, D.; Horrell, S.; Aller, P.; Sandy, J.; Sanchez-Weatherby, J.; Owen, C. D.; Lukacik, P.; Strain-Damerell, C. J.; Owen, R. L.; Walsh, M. A.; Winter, G.

10.1101/2022.01.17.476589 — molecular biology — Posted on 2022-04-14

1977 Control of N2 fixation and NH3 excretion in Azorhizobium caulinodans ORS571

Haskett, T. L.; Karunakaran, R.; Batista, M. B.; Dixon, R.; Poole, P.

10.1101/2022.04.13.488174 — microbiology — Posted on 2022-04-14

1978 Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy

Anichini, A.; Molla, A.; Nicolini, G.; Perotti, V. E.; Sgambelluri, F.; Covre, A.; Fazio, C.; Lofiego, M. F.; Di Giacomo, A. M.; Coral, S.; Manca, A.; Sini, M. C.; Pisano, M.; Noviello, T.; Caruso, F.; Brich, S.; Pruneri, G.; Maurichi, A.; Santinami, M.; Ceccarelli, M.; Palmieri, G.; Maio, M.; Mortarini, R.

10.1101/2022.04.13.488140 — immunology — Posted on 2022-04-14

1979 Perceptual expectations and false percepts generate stimulus-specific activity in distinct layers of the early visual cortex

Haarsma, J.; Deveci, N.; Corbin, N.; Callaghan, M. F.; Kok, P.

10.1101/2022.04.13.488155 — neuroscience — Posted on 2022-04-14

1980 Selective influence of dopamine on electrocortical signatures of error monitoring: a combined EEG and immersive virtual reality study in Parkinson's disease

Pezzetta, R.; Ozkan, D. G.; Era, V.; Tieri, G.; Zabberoni, S.; Taglieri, S.; Costa, A.; Peppe, A.; Caltagirone, C.; Aglioti, S. M.

10.1101/2022.02.05.478638 — neuroscience — Posted on 2022-04-14

1981 Long-Short Term Memory Networks for Electric Source Imaging with Distributed Dipole Models

Hecker, L.; Rupprecht, R.; Tebartz van Elst, L.; Kornmeier, J.

10.1101/2022.04.13.488148 — neuroscience — Posted on 2022-04-14

1982 Slow oscillations promote long range effective communication: the key for memory consolidation in a broken down network

Niknazar, H.; Malerba, P.; Mednick, S. C.

10.1101/2022.04.13.488133 — neuroscience — Posted on 2022-04-14

1983 Rats exhibit higher hepatic stress response pathway capacities compared with mice and humans

Russomanno, G.; Sison-Young, R.; Livoti, L. A.; Coghlan, H.; Jenkins, R. E.; Kunnen, S. J.; Fisher, C. P.; Reddyhoff, D.; Gardner, I.; Rehman, A. H.; Fenwick, S. W.; Jones, A. R.; Vermeil De Conchard, G.; Simonin, G.; Bertheux, H.; Weaver, R.; Liguori, M. J.; Clausznitzer, D.; Stevens, J. L.; Goldring, C. E.; Copple, I. M.

10.1101/2022.04.13.488145 — pharmacology and toxicology — Posted on 2022-04-14

1984 MoDLE: High-performance stochastic modeling of DNA loop extrusion interactions

Rossini, R.; Kumar, V.; Mathelier, A.; Rognes, T.; Paulsen, J.

10.1101/2022.04.13.488157 — bioinformatics — Posted on 2022-04-14

1985 3CAC: improving the classification of phages and plasmids in metagenomic assemblies using assembly graphs

Pu, L.; Shamir, R.

10.1101/2021.11.05.467408 — bioinformatics — Posted on 2022-04-14

1986 Moss functional traits are important drivers for moss and underlying soil bacterial communities: evidence from a chronosequence in an Icelandic glacier forefield

Klarenberg, I. J.; Keuschnig, C. J.; Salazar, A.; Benning, L. G.; Vilhelmsson, O.

10.1101/2022.04.13.488162 — ecology — Posted on 2022-04-14

1987 A Field-Deployable Diagnostic Assay for the Visual Detection of Misfolded Prions

Christenson, P. R.; Li, M.; Rowden, G.; Schwabenlander, M.; Wolf, T. M.; Oh, S.-H.; Larsen, P. A.

10.1101/2021.11.22.469560 — molecular biology — Posted on 2022-04-14

1988 Soluble P2X7 receptor is elevated in the plasma of COVID-19 patients and correlates with disease severity

Garcia-Villalba, J.; Hurtado-Navarro, L.; Penin-Franch, A.; Molina-Lopez, C.; Martinez-Alarcon, L.; Angosto-Bazarra, D.; Baroja-Mazo, A.; Pelegrin, P.

10.1101/2022.03.04.483019 — immunology — Posted on 2022-04-14

1989 Whole-brain dynamics of human sensorimotor adaptation

Standage, D. I.; Areshenkoff, C. N.; Gale, D. J.; Nashed, J. Y.; Flanagan, J. R.; Gallivan, J. P.

10.1101/2020.11.27.401679 — neuroscience — Posted on 2022-04-14

1990 Frequency modulated timer regulates mammalian hibernation

Gibo, S.; Yamaguchi, Y.; Kurosawa, G.

10.1101/2021.11.12.468369 — zoology — Posted on 2022-04-14

1991 Evolution of cell size control is canalized towards adders or sizers by cell cycle structure and selective pressures

Proulx-Giraldeau, F.; Skotheim, J. M.; Francois, P.

10.1101/2022.04.12.488093 — systems biology — Posted on 2022-04-14

1992 Identifying targetable metabolic dependencies across colorectal cancer progression

10.1101/2022.03.23.485483 — cancer biology — Posted on 2022-04-14

1993 Identifying evolutionary divergence in gene expression across species and organs: a case-study using Hawaiian Drosophila

Church, S. H.; Munro, C.; Dunn, C.; Extavour, C. G.

10.1101/2021.11.30.470652 — evolutionary biology — Posted on 2022-04-14

1994 AFFORDABLE, REPLICABLE ROBOTIC MINIRHIZOTRON SAMPLING FOR ROOT DYNAMICS STUDIES

Nair, R.; Strube, M.; Hertel, M.; Kolle, O.; Rolo, V.; Migliavacca, M.

10.1101/2022.01.06.475082 — ecology — Posted on 2022-04-14

1995 Thalamic control of sensory enhancement and sleep spindle properties in a biophysical model of thalamoreticular microcircuitry

Iavarone, E.; Simko, J.; Shi, Y.; Bertschy, M.; Amado, M. G.; Litvak, P.; Kaufmann, A.-K.; O'Reilly, C.; Amsalem, O.; Abdellah, M.; Chevtchenko, G.; Coste, B.; Courcol, J.-D.; Ecker, A.; Favreau, C.; Fleury, A. C.; Van Geit, W.; Gevaert, M.; Guerrero, N. R.; Herttuainen, J.; Ivaska, G.; Kerrien, S.; King, J. G.; Kumbhar, P.; Lurie, P.; Magkanaris, I.; Muddapu, V. R.; Nair, J.; Pereira, F. L.; Perin, R.; Petitjean, F.; Ranjan, R.; Reimann, M.; Soltuzu, L.; Sy, M. F.; Ulbrich, A.; Tuncel, M. A.; Wolf, M.; Clasca, F.; Markram, H.; Hill, S. L.

10.1101/2022.02.28.482273 — neuroscience — Posted on 2022-04-14

1996 Seeing the future: predictive control in neural models of ocular accommodation

Read, J. C. A.; Kaspiris-Rousellis, C.; Wood, T.; Wu, B.; Vlaskamp, B. N. S.; Schor, C. M.

10.1101/2021.12.09.471909 — neuroscience — Posted on 2022-04-14

1997 Place cells are non-randomly clustered by field location in CA1 hippocampus

Wirtshafter, H. S.; Disterhoft, J.

10.1101/2022.03.15.484476 — neuroscience — Posted on 2022-04-14

1998 Interplay between LHCSR proteins and state transitions governs the NPQ response in intact cells of Chlamydomonas during light fluctuations.

Steen, C.; Burlacot, A.; Short, A.; Niyogi, K. K.; Fleming, G.

10.1101/2021.12.31.474662 — plant biology — Posted on 2022-04-14

1999 Distinct and common features of numerical and structural chromosomal instability across different cancer types

Zhang, X.; Kschischo, M.

10.1101/2021.10.15.464567 — cancer biology — Posted on 2022-04-14

2000 Shell Microelectrode Arrays (MEAs) for brain organoids

Huang, Q.; Tang, B.; Romero, J. C.; Yang, Y.; Elsayed, S. K.; Pahapale, G.; Lee, T.-J.; Pantoja, I. E. M.; Han, F.; Berlinicke, C.; Xiang, T.; Solazzo, M.; Hartung, T.; Qin, Z.; Caffo, B.; Smirnova, L.; Gracias, D. H.

10.1101/2022.04.13.488025 — bioengineering — Posted on 2022-04-14

2001 Multi-omics analyses cannot identify true-positive novel associations from underpowered genome-wide association studies of four brain-related traits

Baranger, D. A.; Hatoum, A. S.; Polimanti, R. A.; Gelernter, J.; Edenberg, H. J.; Bogdan, R.; Agrawal, A.

10.1101/2022.04.13.487655 — genetics — Posted on 2022-04-14

2002 Tripartite networks show that keystone species can multitask

Timoteo, S.; Albrecht, J.; Rumeu, B.; Norte, A. C.; Traveset, A.; Frost, C.; Marchante, E.; Lopez-Nunez, F. A.; Peralta, G.; Memmott, J.; Olesen, J.; Costa, J. M.; da Silva, L. P.; Carvalheiro, L. G.; Correia, M.; Staab, M.; Blüthgen, N.; Farwig, N.; Hervias-Parejo, S.; Mironov, S.; Rodriguez-Echeverria, S.; Heleno, R.

10.1101/2021.04.01.437523 — ecology — Posted on 2022-04-14

2003 Repeated introduction of micropollutants enhances microbial succession despite stable degradation patterns

Izabel-Shen, D.; Li, S.; Luo, T.; Wang, J.; Li, Y.; Sun, Q.; Yu, C.-P.; Hu, A.

10.1101/2021.08.24.457489 — ecology — Posted on 2022-04-14

2004 Molecular basis of indispensable accuracy of mammalian miRNA biogenesis

Zapletal, D.; Svobodova, E.; Pasulka, J.; Malik, R.; Kubicek, K.; Zanova, M.; Much, C.; Sebesta, M.; Buccheri, V.; Horvat, F.; Jenickova, I.; Prochazkova, M.; Prochazka, J.; Pinkas, M.; Novacek, J.; Joseph, D. F.; Sedlacek, R.; O'Carroll, D.; Stefl, R.; Svoboda, P.

10.1101/2022.04.13.488181 — molecular biology — Posted on 2022-04-14

2005 Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus

Hoy, M. J.; Park, E.; Lee, H.; Lim, W. Y.; Cole, D. C.; DeBouver, N. D.; Bobay, B. G.; Pierce, P. G.; Fox, D.; Ciofani, M.; Juvvadi, P. R.; Steinbach, W.; Hong, J.; Heitman, J.

10.1101/2022.03.25.485831 — microbiology — Posted on 2022-04-14

2006 Prenatal development of neonatal vocalizations

Ghazanfar, A. A.; Narayanan, D.; Takahashi, D. Y.; Hlavaty, S.; Huang, J.; Kelly, L.

10.1101/2022.04.13.488158 — neuroscience — Posted on 2022-04-14

2007 Every individual makes a difference: A trinity derived from linking individual brain morphometry, connectivity and mentalising ability

Li, Z.; Dong, Q.; Hu, B.; Wu, H.

10.1101/2022.04.11.487870 — neuroscience — Posted on 2022-04-14

2008 Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states

Al-Dalahmah, O.; Argenziano, M.; Mahajan, A.; Furnari, J.; Paryani, F.; Boyett, D.; Save, A.; Khan, F.; Li, J.; Lu, H.; Sun, Y.; Tuddenham, J.; goldberg, a. r.; Dovas, A.; Banu, M.; Sudhakar, T.; Bush, E.; Lassman, A.; Bruce, J.; Sims, P.; Menon, V.; Canoll, P.

10.1101/2021.07.06.451295 — pathology — Posted on 2022-04-14

2009 Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins

Zeng, X.; Ruff, K. M.; Pappu, R. V.

10.1101/2022.01.11.475920 — biophysics — Posted on 2022-04-14

2010 Dynamic play between human N-α-acetyltransferase D and H4-mutant histones: Molecular dynamics study

Rathod, S. B.; Srivastava, K. R.

10.1101/2022.03.15.484466 — biophysics — Posted on 2022-04-14

2011 Cellxgene VIP unleashes full power of interactive visualization and integrative analysis of scRNA-seq, spatial transcriptomics, and multiome data

Li, K.; Ouyang, Z.; Chen, Y.; Gagnon, J.; Lin, D.; Mingueneau, M.; Chen, W.; Sexton, D.; Zhang, B.

10.1101/2020.08.28.270652 — bioinformatics — Posted on 2022-04-14

2012 Risk modelling of single cell populations revealed the heterogeneity of immune infiltration in hepatocellular carcinoma

Wang, L.; Chen, Y.; Mao, F.; Sun, Z.; Liu, X.

10.1101/2021.06.26.450025 — bioinformatics — Posted on 2022-04-14

2013 Interfacial tension driven open droplet microfluidics

Khor, J. W.; Lee, U. N.; Berthier, J.; Berthier, E.; Theberge, A. B.

10.1101/2021.07.29.454194 — bioengineering — Posted on 2022-04-14

2014 Specific sequence of arrival promotes coexistence via spatial niche preemption by the weak competitor

Fragata, I.; Costa-Pereira, R.; Kozak, M.; Majer, A.; Godoy, O.; Magalhaes, S.

10.1101/2021.10.06.463344 — ecology — Posted on 2022-04-14

2015 Bacterial and fungal communities experience rapid secondary succession during the first year following a wildfire in a California chaparral.

Pulido-Chavez, M. F.; Randolph, J. W. J.; Zalman, C.; Larios, L.; Homyak, P. M.; Glassman, S. I.

10.1101/2021.12.07.471678 — microbiology — Posted on 2022-04-14

2016 Age- and episodic memory-related differences in task-based functional connectivity in women and men

Subramaniapillai, S.; Rajagopal, S.; Ankudowich, E.; Pasvanis, S.; Misic, B.; Rajah, N.

10.1101/2021.07.27.453878 — neuroscience — Posted on 2022-04-14

2017 Building a Tissue-unbiased Brain Template of Fibre Orientation Distribution and Tractography with Multimodal Registration

Lv, J.; Zeng, R.; Ho, M. P.; D'Souza, A.; Calamante, F.

10.1101/2022.04.13.488117 — neuroscience — Posted on 2022-04-14

2018 Multiphasic calcium signatures in the cytosol and nucleus of Lotus japonicus roots unlock the early discrimination of fungal signals

Binci, F.; Kleine-Vehn, J.; Giovannetti, M.; Navazio, L.

10.1101/2022.04.13.487819 — plant biology — Posted on 2022-04-14

2019 The cilia enriched oxysterol 7β,27-DHC is required for polycystin activation

Ha, K.; Mundt, N.; Bisignano, P.; Pinedo, A.; Cao, E.; Reiter, J.; Raleigh, D.; Delling, M.

10.1101/2022.04.13.488122 — physiology — Posted on 2022-04-14

2020 Effects of local versus global competition on reproductive skew and sex differences in social dominance behaviour

Leimar, O.; Bshary, R.

10.1101/2022.04.13.488121 — animal behavior and cognition — Posted on 2022-04-14

2021 Proteomic study of differentially expressed proteins in seeds between parents and offspring of castor bean (Ricinus communis L.)

Xiaotian, L.; Rui, L.; Yanxin, Z.; Mingda, Y.; Yanpeng, W.; Xuemei, H.; Zhiyan, W.; Yumiao, H.; Fenglan, H.

10.1101/2022.04.13.488138 — molecular biology — Posted on 2022-04-13

2022 Attention Samples Items in Visual Working Memory Rhythmically

Chota, S.; Leto, C.; van Zantwijk, L.; van der Stigchel, S.

10.1101/2022.04.12.488012 — neuroscience — Posted on 2022-04-14

2023 BCL-xL antagonizes the deleterious effects of KRAS on mitochondrial scaffolding

Belaid, N.; Basseville, A.; Andre-Gregoire, G.; Fetiveau, A.; Maillet, L.; Guilloneau, F.; Leduc, M.; Guette, C.; Desaubry, L.; Gavard, J.; Gautier, F.; Juin, P.

10.1101/2022.04.13.488211 — cell biology — Posted on 2022-04-13

2024 Efficient and sensitive profiling of RNA-protein interactions using TLC-CLIP

Ernst, C.; Duc, J.; Trono, D.

10.1101/2022.04.13.488168 — molecular biology — Posted on 2022-04-13

2025 Evaluation of oral baits and distribution methods for Tasmanian devils (Sarcophilus harrisii)

Dempsey, S.; Pye, R. J.; Gilbert, A. T.; Benson-Amram, S.; Fountain-Jones, N. M.; Moffat, J. M.; Smyser, T. J.; Flies, A. S.

10.1101/2022.04.13.486902 — zoology — Posted on 2022-04-13

2026 N-terminal helices and A domain of archaeal FtsY facilitate SRP54 binding and the association with cell membrane

Gupta, S.; Sinha, S.; Bhakta, K.; Bhowmick, A.; Ghosh, A.

10.1101/2022.04.13.488184 — biochemistry — Posted on 2022-04-13

2027 Microbial landscape ecology: landscape structure better predicts soil protist diversity than local edaphic variables in alpine meadows

Seppey, C. V. W.; Lara, E.; Broennimann, O.; Guisan, A.; Malard, L.; Yashiro, E.; Fournier, B.

10.1101/2022.04.13.488160 — ecology — Posted on 2022-04-13

2028 ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion Through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

Mezgarzadeh, J. S.; Romine, I. C.; Smith-Cohen, E. M.; Grandjean, J. M.; Kelly, J. W.; Genereux, J. C.; Wiseman, L.

10.1101/2022.04.13.488200 — cell biology — Posted on 2022-04-13

2029 Generation and characterization of iPSC lines (UOHi001-A, UOHi002-A)From a patient with SHANK3 mutation and her healthy mother

Nayak, R.; Rosh, I.; Rabinski, T.; Percia, M. M.; Stern, S.

10.1101/2022.04.13.486968 — cell biology — Posted on 2022-04-13

2030 Molecular basis of indispensable accuracy of mammalian miRNA biogenesis

10.1101/2022.04.13.488181 — molecular biology — Posted on 2022-04-13

2031 The transcription factor RXRA regulates lipid metabolism in duck myoblasts by the CD36 network

Pan, Z.; Geng, Z.

10.1101/2022.04.13.488167 — molecular biology — Posted on 2022-04-13

2032 Genomic analysis of population structure, antimicrobial resistance, and virulent factors of methicillin-resistant Macrococcus caseolyticus in global lineages

Zhang, Y.; Min, S.; Sun, Y.; Ye, J.; Zhou, Z.; Li, H.

10.1101/2022.04.12.488041 — microbiology — Posted on 2022-04-13

2033 Catecholaminergic cell type-specific expression of Cre recombinase in knock-in transgenic rats generated by the Combi-CRISPR technology

Matsushita, N.; Nishizawa, K.; Kato, S.; Iguchi, Y.; Fukabori, R.; Takeuchi, K.; Miyasaka, Y.; Mashimo, T.; Kobayashi, K.

10.1101/2022.04.13.488137 — neuroscience — Posted on 2022-04-13

2034 Mutations in DNA polymerase δ subunit 1 mediate CMD2-type resistance to Cassava Mosaic Geminiviruses

Lim, Y.-W.; Mansfeld, B. N.; Schlapfer, P.; Gilbert, K.; Narayanan, N.; Qi, W.; Wang, Q.; Zhong, Z.; Boyher, A.; Gehan, J.; Beyene, G.; Lin, D.; Esuma, W.; Feng, S.; Chanez, C.; Eggenberger, N.; Adiga, G.; Jacobsen, S. E.; Taylor, N. J.; Gruissem, W.; Bart, R. S.

10.1101/2022.04.13.487913 — plant biology — Posted on 2022-04-13

2035 Is It A Barrel? General Features of Transmembrane Beta Barrels from a Large Database

Montezano, D.; Bernstein, R.; Copeland, M.; Slusky, J. S.

10.1101/2022.04.13.488089 — bioinformatics — Posted on 2022-04-13

2036 Profiling the size-dependent heterogeneity of membrane proteins in a mixed population of small extracellular vesicle for potential cancer diagnosis

Zhai, C.; Xie, F.; Zeng, Q.; Zheng, W.; Wang, J.; Hu, H.; Yang, Y.; Ding, X.; Yu, H.

10.1101/2022.04.13.488159 — biochemistry — Posted on 2022-04-13

2037 Evolutionary Origin of Vertebrate OCT4/POU5 Functions in Supporting Pluripotency

Sukparangsi, W.; Morganti, E.; Lowndes, M.; Mayeur, H.; Weisser, M.; Hammachi, F.; Peradziryi, H.; Roske, F.; Hölzenspies, J.; Livigni, A.; Godard, B. G.; Sugahara, F.; Kuratani, S.; Montoya, G.; Frankenberg, S. R.; Mazan, S.; Brickman, J. M.

10.1101/2022.04.13.488202 — developmental biology — Posted on 2022-04-13

2038 Spatiotemporal proximity labeling tools to track GlcNAc sugar-modified functional protein hubs during cellular signaling

Liu, Y.; Nelson, Z. M.; Reda, A.; Fehl, C.

10.1101/2022.04.13.488185 — cell biology — Posted on 2022-04-13

2039 Multiplex genome editing of human pluripotent stem cells using Cpf1

Ma, H.; Jaenisch, R.

10.1101/2022.04.13.488123 — molecular biology — Posted on 2022-04-13

2040 Extensive diversity and rapid turnover of phage defense repertoires in cheese-associated bacterial communities

Somerville, V.; Schowing, T.; Chabas, H.; Schmidt, R. S.; von Ah, U.; Bruggmann, R.; Engel, P.

10.1101/2022.04.13.488139 — microbiology — Posted on 2022-04-13

2041 Heavy metal pollution impacts soil bacterial community structure and antimicrobial resistance at the Birmingham 35th Avenue Superfund Site

Goswami, A.; Adkins-Jablonsky, S.; Barreto Filho, M. M.; Schilling, M.; Dawson, A.; Heiser, S.; O'Connor, A.; Walker, M.; Roberts, Q.; Morris, J.

10.1101/2022.04.12.488090 — microbiology — Posted on 2022-04-13

2042 Form follows function: Variable microtubule architecture in the malaria parasite

Ferreira, J. L.; Prazak, V.; Vasishtan, D.; Siggel, M.; Hentzschel, F.; Pietsch, E.; Kosinski, J.; Frischknecht, F.; Gilberger, T.-W.; Grünewald, K.

10.1101/2022.04.13.488170 — microbiology — Posted on 2022-04-13

2043 Control of N2 fixation and NH3 excretion in Azorhizobium caulinodans ORS571

Haskett, T. L.; Karunakaran, R.; Batista, M. B.; Dixon, R.; Poole, P.

10.1101/2022.04.13.488174 — microbiology — Posted on 2022-04-13

2044 In macrophages fatty acid oxidation spares glutamate for use in diverse metabolic pathways required for alternative activation

van Teijlingen Bakker, N.; Flachsmann, L.; Carrizo, G. E.; Sanin, D. E.; Lawless, S.; Castoldi, A.; Monteiro, L.; Kabat, A. M.; Matsushita, M.; Haessler, F.; Patterson, A.; Klein Geltink, R.; O'Sullivan, D.; Pearce, E. L.; Pearce, E. J.

10.1101/2022.04.13.487890 — immunology — Posted on 2022-04-13

2045 Low-efficiency conversion of proliferative glia into induced neurons by Ascl1 in the postnatal mouse cerebral cortex in vivo

Galante, C.; Marichal, N.; Schuurmans, C.; Berninger, B.; Peron, S.

10.1101/2022.04.13.488173 — neuroscience — Posted on 2022-04-13

2046 Genomic analyses of wild and cultivated bacanora agave (Agave angustifolia var. pacifica) reveal inbreeding, few signs of cultivation history and shallow population structure

Klimova, A.; Mondragon, K. Y. R.; Freaner, F. M.; Planter, E. A.; Eguiarte, L. E.

10.1101/2022.04.13.488215 — plant biology — Posted on 2022-04-13

2047 Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter

del Alamo, D.; DeSousa, L.; Nair, R. M.; Rahman, S.; Meiler, J.; Mchaourab, H.

10.1101/2022.04.13.488180 — biophysics — Posted on 2022-04-13

2048 Single-chain and condensed-state behavior of hnRNPA1 from molecular simulations

Bauer, D. J.; Stelzl, L. S.; Nikoubashman, A.

10.1101/2022.04.13.488036 — biophysics — Posted on 2022-04-13

2049 A novel PNGase Rc for improved protein N-deglycosylation in bioanalytics and HDX-MS epitope mapping under challenging conditions

Gramlich, M.; Maier, S.; Kaiser, P. D.; Traenkle, B.; Wagner, T. R.; Voglmeir, J.; Stoll, D.; Rothbauer, U.; Zeck, A.

10.1101/2022.04.13.488165 — biochemistry — Posted on 2022-04-13

2050 Bacillus thuringiensis Cry1A toxins divert progenitor cell fate toward enteroendocrine lineage by diminishing cell adhesion with intestinal stem cells

JNEID, R.; LOUDHAIEF, R.; ZUCCHINI-PASCAL, N.; NAWROT-ESPOSITO, M.-P.; FICHANT, A.; ROUSSET, R.; BONIS, M.; OSMAN, D.; GALLET, A.

10.1101/2022.04.13.488147 — cell biology — Posted on 2022-04-13

2051 The Omicron (B.1.1.529) SARS-CoV-2 variant of concern also affects companion animals

Sanchez-Morales, L.; Sanchez-Vizcaino, J. M.; Perez-Sancho, M.; Dominguez, L.; Barroso-Arevalo, S.

10.1101/2022.04.13.488132 — molecular biology — Posted on 2022-04-13

2052 Markers of Fungal Translocation Are Elevated During Post-Acute Sequelae of SARS-CoV-2 Infection and Induce NF-κB Triggered Inflammation.

Giron, L. B.; Peluso, M.; Ding, J.; Kenny, G.; Zilberstein, N. F.; Koshy, J.; Hong, K. Y.; Rasmussen, H.; Miller, G.; Bishehsari, F.; Balk, R. A.; Moy, J. N.; Hoh, R.; Lu, S.; Goldman, A. R.; Tang, H.-Y.; Yee, B. C.; Chenna, A.; Winslow, J. W.; Petropoulos, C. J.; Kelly, J. D.; Wasse, H.; Martin, J. N.; Liu, Q.; Keshavarzian, A.; Landay, A.; Deeks, S. G.; Henrich, T. J.; Abdel-Mohsen, M.

10.1101/2022.04.12.488051 — microbiology — Posted on 2022-04-13

2053 An instance-specific causal framework for learning intercellular communication networks that define microenvironments of individual tumors

Chen, X.; Chen, L.; Kurten, C. H. L.; Jabbari, F.; Vujanovic, L.; Ding, Y.; Kulkarni, A.; Tabib, T.; Lafyatis, R.; Cooper, G. F.; Ferris, R.; Lu, X.; Lu, K.; Lu, B.

10.1101/2021.11.11.467838 — cancer biology — Posted on 2022-04-13

2054 Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.1 and BA.2 variants and their mouse origins

Xu, Y.; Wu, C.; Cao, X.; Gu, C.; Liu, H.; Jiang, M.; Wang, X.; Yuan, Q.; Wu, K.; Liu, J.; He, X.; Wang, D.; Wang, X.; Deng, S.-J.; Xu, H. E.; Yin, W.

10.1101/2022.04.12.488075 — biophysics — Posted on 2022-04-13

2055 SARS-CoV-2 Delta breakthrough infections in vaccinated patients

Zou, J.; Xie, X.; Liu, M.; Shi, P.-Y.; Ren, P.

10.1101/2022.04.12.488092 — microbiology — Posted on 2022-04-13

2056 Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

Li, M.; Ren, Y.; Aw, Z. Q.; Chen, B.; Yang, Z.; Lei, Y.; Cheng, L.; Liang, Q.; Hong, J.; Yang, Y.; Chen, J.; Wong, Y. H.; Shan, S.; Zhang, S.; Ge, J.; Wang, R.; Shi, X.; Zhang, Q.; Zhang, Z.; Chu, J. J. H.; Wang, X.; Zhang, L.

10.1101/2022.04.12.488087 — immunology — Posted on 2022-04-13

2057 Offline memory replay in recurrent neuronal networks emerges from constraints on online dynamics

Milstein, A. D.; Tran, S.; Ng, G.; Soltesz, I.

10.1101/2021.10.27.466186 — neuroscience — Posted on 2022-04-13

2058 A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition

Soto-Feliciano, Y. M.; Sanchez-Rivera, F. J.; Perner, F.; Barrows, D. W.; Kastenhuber, E. R.; Ho, Y.-J.; Carroll, T.; Xiong, Y.; Anand, D.; Soshnev, A.; Gates, L.; Beytagh, M. C.; Cheon, D.; Gu, S.; Liu, X. S.; Krivtsov, A. V.; Meneses, M.; de Stanchina, E.; Stone, R. M.; Armstrong, S. A.; Lowe, S. W.; Allis, C. D.

10.1101/2021.10.22.465184 — cancer biology — Posted on 2022-04-13

2059 Cell type identification in spatial transcriptomics data can be improved by leveraging cell-type-informative paired tissue images using a Bayesian probabilistic model.

Zubair, A.; Chapple, R. H.; Natarajan, S.; Wright, W. C.; Pan, M.; Lee, H.-M.; Tillman, H.; Easton, J.; Geeleher, P.

10.1101/2021.11.10.468082 — bioinformatics — Posted on 2022-04-13

2060 Depletion of Sun1/2 Induces Heterochromatin Accrual in Mesenchymal Stem Cells during Adipogenesis

Goelzer, M.; Howard, S.; Zavala, A.; Conway, D. E.; Rubin, J.; van Wijnen, A. J.; Uzer, G.

10.1101/2022.02.15.480528 — bioengineering — Posted on 2022-04-13

2061 Disrupting the plastid-hosted iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability

Renaud, E. A.; Pamukcu, S.; Cerutti, A.; Berry, L.; Lemaire-Vieille, C.; Yamaryo-Botte, Y.; Botte, C. Y.; Besteiro, S.

10.1101/2022.03.18.484844 — microbiology — Posted on 2022-04-13

2062 Polar growth protein Wag31 undergoes changes in homo-oligomeric network topology, and has distinct functions at both cell poles and the septum

Habibi Arejan, N.; Patel, P. B.; Quintanilla, S.; Emami Saleh, A.; Boutte, C. C.

10.1101/2022.04.12.488113 — microbiology — Posted on 2022-04-13

2063 Comparative immunogenicity of bacterially expressed soluble trimers and nanoparticle displayed influenza hemagglutinin stem immunogens

Kar, U.; Khaleeq, S.; Garg, P.; Bhat, M.; Reddy, P.; Vignesh, V. S.; Upadhyaya, A.; Das, M.; Ghadiyaram, C.; Pandey, S.; Dutta, S.; Varadarajan, R.

10.1101/2021.03.14.435294 — immunology — Posted on 2022-04-13

2064 Sensitivity to the slope of the amplitude spectrum is dependent on the spectral slopes of recently viewed environments: A visual adaptation study in modified reality

Richard, B.; Shafto, P.

10.1101/2021.08.19.456985 — neuroscience — Posted on 2022-04-13

2065 Taste quality and hunger interactions in a feeding sensorimotor circuit

Shiu, P. K.; Sterne, G. R.; Engert, S.; Dickson, B.; Scott, K.

10.1101/2022.03.06.483180 — neuroscience — Posted on 2022-04-13

2066 Analysis of community connectivity in spatial transcriptomics data

Allen, C.; Jung, K. J.; Chang, Y.; Ma, Q.; Chung, D.

10.1101/2022.04.11.487907 — bioinformatics — Posted on 2022-04-13

2067 Target Class Profiling of Small Molecule Methyltransferases

Hanson, Q.; Shen, M.; Guo, H.; Cho, I.-J.; Hall, M.

10.1101/2022.03.24.485659 — biochemistry — Posted on 2022-04-13

2068 DNA damage response signaling is crucial for effective Chikungunya virus replication

Chatterjee, S.; Kumar, S.; Mamidi, P.; Datey, A.; Sengupta, S.; Mahish, C.; Laha, E.; De, S.; Keshry, S. S.; Nayak, T. K.; Ghosh, S.; Singh, S.; Subudhi, B. B.; Chattopadhyay, S.; Chattopadhyay, S.

10.1101/2022.04.12.488112 — microbiology — Posted on 2022-04-13

2069 Systematic conformation-to-phenotype mapping via limited deep-sequencing of proteins

Serebryany, E.; Zhao, V. Y.; Park, K.; Bitran, A.; Trauger, S. A.; Budnik, B.; Shakhnovich, E. I.

10.1101/2022.04.12.488104 — biophysics — Posted on 2022-04-13

2070 Benchmarking community-wide estimates of growth potential from metagenomes using codon usage statistics

Weissman, J. L.; Peras, M.; Barnum, T. P.; Fuhrman, J. A.

10.1101/2022.04.12.488109 — bioinformatics — Posted on 2022-04-13

2071 Multiple waves of viral invasions in Symbiodiniaceae algal genomes

Benites, L. F. d. A.; Stephens, T. G.; Bhattacharya, D.

10.1101/2022.04.12.488082 — evolutionary biology — Posted on 2022-04-13

2072 Sun4 is a type II transmembrane protein of the spermatid inner nuclear membrane that forms heteromeric assemblies with Sun3 and interacts with Lamin B3

Thoma, H.; Gruenewald, L.; Pasch, E.; Alsheimer, M.

10.1101/2022.04.13.488151 — cell biology — Posted on 2022-04-13

2073 Stimulated emission depletion microscopy with a single depletion laser using five fluorochromes and fluorescence lifetime phasor separation

Gonzalez Pisfil, M.; Nadelson, I.; Bergner, B.; Rottmeier, S.; Thomae, A. W.; Dietzel, S.

10.1101/2022.04.13.487856 — cell biology — Posted on 2022-04-13

2074 The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

GARNER, K. E. L.; Salter, A.; Lau, C. K.; Manickam, G.; Villemant, C.; Granger, E. P.; McNee, G.; Woodman, P. G.; Davies, O. R.; Burke, B. E.; Allan, V. J.

10.1101/2022.04.13.488131 — cell biology — Posted on 2022-04-13

2075 Microvesicle-Mediated Tissue Regeneration Mitigates the Effects of Cellular Ageing

Panagiotou, N.; McGuiness, D.; Jaminon, A. M. G.; Mees, B.; Selman, C.; Schurgers, L.; Shiels, P. G.

10.1101/2022.04.13.488143 — cell biology — Posted on 2022-04-13

2076 A quantitative and spatial analysis of cell cycle regulators during the fission yeast cell cycle

Curran, S.; Dey, G.; Rees, P.; Nurse, P.

10.1101/2022.04.13.488127 — cell biology — Posted on 2022-04-13

2077 A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag

Yim, W. W.-Y.; Yamamoto, H.; Mizushima, N.

10.1101/2022.04.13.488149 — cell biology — Posted on 2022-04-13

2078 Nuclear transport under stress phenocopies transport defects in models of C9Orf72 ALS

Semmelink, M. F.; Jafarinia, H.; Wolters, J. C.; Gheorghe, T.; Mouton, S. N.; Steen, A.; Onck, P. R.; Veenhoff, L. M.

10.1101/2022.04.13.488135 — cell biology — Posted on 2022-04-13

2079 Transcriptional circuitry of NKX2-1 and SOX1 defines an unrecognized lineage subtype of small cell lung cancer

Kong, R.; Patel, A. S.; Sato, T.; Yoo, S.; Bao, L.; Sinha, A.; Jiang, F.; tian, y.; Fridrikh, M.; Liu, S.; Feng, J.; He, X.; Jiang, J.; Ma, Y.; Grullon, K.; Yang, D.; Powell, C. A.; Beasley, M. B.; Zhu, J.; Snyder, E.; Li, S.; Watanabe, H.

10.1101/2022.03.06.483161 — molecular biology — Posted on 2022-04-13

2080 Improving the fidelity of uridine analog incorporation during in vitro transcription.

Chen, T.-H.; Potapov, V.; Dai, N.; Ong, J.; Roy, B.

10.1101/2022.04.12.488100 — molecular biology — Posted on 2022-04-13

2081 Representational integration and differentiation in the human hippocampus following goal-directed navigation

Fernandez, C.; Jiang, J.; Wang, S.-F.; Choi, H.; Wagner, A. D.

10.1101/2022.04.12.488078 — neuroscience — Posted on 2022-04-13

2082 Reelin deficiency exacerbates cocaine-induced hyperlocomotion by enhancing neuronal activity in the dorsomedial striatum.

de Guglielmo, G.; Iemolo, A.; Nur, A.; Turner, A.; Montilla-Perez, P.; Telese, F.

10.1101/2022.04.12.488105 — neuroscience — Posted on 2022-04-13

2083 Nav1.2 and BK channels interaction shapes the action potential in the axon initial segment

Filipis, L.; Blomer, L. A.; Montnach, J.; De Waard, M.; Canepari, M.

10.1101/2022.04.12.488116 — neuroscience — Posted on 2022-04-13

2084 Modeling vital rates and age-sex structure of Pacific arctic phocids: influence on aerial survey correction factors

Conn, P. B.; Trukhanova, I. S.

10.1101/2022.04.12.487942 — zoology — Posted on 2022-04-13

2085 Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalk

Shao, X.; Li, C.; Yang, H.; Lu, X.; Liao, J.; Qian, J.; Wang, K.; Cheng, J.; Yang, P.; Chen, H.; Xu, X.; Fan, X.

10.1101/2022.04.12.488047 — bioinformatics — Posted on 2022-04-13

2086 Estimation of Left Ventricular Mechanical Activation Times from Motion-Corrected Cardiac 4DCT Images

Manohar, A.; Yang, J.; Pack, J. D.; McVeigh, E. R.

10.1101/2022.04.12.488106 — bioengineering — Posted on 2022-04-13

2087 Interpreting the pervasive observation of U-shaped Site Frequency Spectra

Freund, F.; Kerdoncuff, E.; Matuszewski, S.; Lapierre, M.; Hildebrandt, M.; Jensen, J. D.; Ferretti, L.; Lambert, A.; Sackton, T. B.; Achaz, G.

10.1101/2022.04.12.488084 — evolutionary biology — Posted on 2022-04-13

2088 Legacy effect of microplastics on plant-soil feedbacks

Lozano, Y. M.; Rillig, M. C.

10.1101/2022.04.12.488083 — ecology — Posted on 2022-04-13

2089 The use of alternative spawning habitats by the American horseshoe crab, Limulus polyphemus

Sasson, D.; Chabot, C. C.; Mattei, J. H.; Kendrick, M. R.; Brunson, J. F.; Huber, J. H.; Kasinak, J.-M. E.; Puckette, P. T.; Sundin, G.; Kingsley-Smith, P. R.

10.1101/2022.04.12.488058 — ecology — Posted on 2022-04-13

2090 Regulation of Store-Operated Ca2+ Entry by IP3 Receptors Independent of Their Ability to Release Ca2+

Chakraborty, P.; Deb, B. K.; Taylor, C. W.; Hasan, G.

10.1101/2022.04.12.488111 — cell biology — Posted on 2022-04-13

2091 Resolving subcellular pH with a quantitative fluorescent lifetime biosensor

Rennick, J. J.; Nowell, C. J.; Pouton, C. W.; Johnston, A. P. R.

10.1101/2022.04.13.488146 — cell biology — Posted on 2022-04-13

2092 Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability

Taketomi, T.; Yasuda, T.; Morita, R.; Kim, J.; Shigeta, Y.; Eroglu, C.; Harada, R.; Tsuruta, F.

10.1101/2022.04.12.488096 — molecular biology — Posted on 2022-04-13

2093 Polar growth protein Wag31 undergoes changes in homo-oligomeric network topology, and has distinct functions at both cell poles and the septum

Habibi Arejan, N.; Patel, P. B.; Quintanilla, S.; Emami Saleh, A.; Boutte, C. C.

10.1101/2022.04.12.488113 — microbiology — Posted on 2022-04-13

2094 Reduced ventral attention network connectivity is linked to the accelerated maturation of adult-like cortical organization in childhood

Dong, H.; Holmes, A.; Zuo, X.-N.

10.1101/2022.04.12.488101 — neuroscience — Posted on 2022-04-13

2095 Conserved cell-type specific signature of resilience to Alzheimer's disease nominates role for excitatory cortical neurons

Telpoukhovskaia, M. A.; Hadad, N.; Gurdon, B.; Dai, M.; Ouellette, A. R.; Neuner, S. M.; Dunn, A. R.; Hansen, S.; Wu, Y.; Dumitrescu, L.; O'Connell, K. M. S.; Dammer, E. B.; Seyfried, N. T.; Muzumdar, S.; Gillis, J.; Robson, P.; Zhang, J.-G.; Hohman, T. J.; Philip, V.; Menon, V.; Kaczorowski, C. C.

10.1101/2022.04.12.487877 — neuroscience — Posted on 2022-04-13

2096 Tuned inhibitory firing rate and connection weights as emergent network properties

Lagzi, F.; Fairhall, A.

10.1101/2022.04.12.488114 — neuroscience — Posted on 2022-04-13

2097 Defining tertiary sulci in lateral prefrontal cortex in chimpanzees using human predictions

Hathaway, C.; Voorhies, W. I.; Sathishkumar, N.; Mittal, C.; Yao, J. K.; Miller, J. A.; Parker, B.; Weiner, K. S.

10.1101/2022.04.12.488091 — neuroscience — Posted on 2022-04-13

2098 Radioactive Contamination in Feral Dogs in the Chernobyl Exclusion Zone: Population Body-Burden Survey and Implications for Human Radiation Exposure

Hecla, J.; Kambarian, E.; Tubbs, R.; McKinley, C.; Berliner, A. J.; Russell, K.; Spatola, G.; Chertok, J.; Braun, W.; Hank, N.; Marquette, C.; Betz, J.; Paik, T.; Chenery, M.; Cagan, A.; Willis, C.; Mousseau, T.

10.1101/2022.04.12.487820 — zoology — Posted on 2022-04-13

2099 Evolution of cell size control is canalized towards adders or sizers by cell cycle structure and selective pressures

Proulx-Giraldeau, F.; Skotheim, J. M.; Francois, P.

10.1101/2022.04.12.488093 — systems biology — Posted on 2022-04-13

2100 The effect of trans-cinnamic acid isolated from the root cultures of the Baikal skullcap (Scutellaria baicalensis) on the life expectancy and survival of Caenorhabditis elegans

Dyshlyuk, L. S.; Drozdova, M. Y.; Dolganyuk, V. F.

10.1101/2022.04.12.488097 — plant biology — Posted on 2022-04-13

2101 The effect of biohanin A isolated from the callus culture of meadow clover (Trifolium pratense L.) on the life expectancy and survival of Caenorhabditis elegans

Drozdova, M. Y.; Milentyeva, I. S.; Le, V. M.

10.1101/2022.04.12.488102 — plant biology — Posted on 2022-04-13

2102 Acute myeloid leukemia expresses a specific group of olfactory receptors

Guardia, G. D. A.; Goncalves, R. N.; Buzatto, V. C.; da Costa, J. B.; Zalcberg, I.; Ramires, J.; Malnic, B.; Gutiyama, L. M.; Galante, P. A. F.

10.1101/2022.04.12.488071 — cancer biology — Posted on 2022-04-13

2103 Origin of Protein Quake: Energy Waves Conducted by a Precise Mechanical Machine

Li, H.; Wu, S.; Ma, A.

10.1101/2022.04.12.488080 — biophysics — Posted on 2022-04-13

2104 Validation of genetic variants from NGS data using Deep Convolutional Neural Networks

Vaisband, M.; Schubert, M.; Gassner, F. J.; Geisberger, R.; Greil, R.; Zaborsky, N.; Hasenauer, J.

10.1101/2022.04.12.488021 — bioinformatics — Posted on 2022-04-13

2105 Convolutional networks for supervised mining of molecular patterns within cellular context

de Teresa, I.; Goetz, S. K.; Mattausch, A.; Stojanovska, F.; Zimmerli, C. E.; Toro-Nahuelpan, M.; Cheng, D. W. C.; Tollervey, F.; Pape, C.; Beck, M.; Kreshuk, A.; Mahamid, J.; Zaugg, J. B.

10.1101/2022.04.12.488077 — bioinformatics — Posted on 2022-04-13

2106 Adding gene transcripts into genomic prediction improves accuracy and reveals sampling time dependence

Perez, B. C.; Bink, M. C. A. M.; Svenson, K. L.; Churchill, G. A.; Calus, M. P. L.

10.1101/2022.04.12.488053 — genetics — Posted on 2022-04-13

2107 An Efficient CRISPR-Cas9 DNA Editing Methodology Applicable for iPSC Disease Modelling

Namipashaki, A.; Liu, X.; Pugsley, K.; Lim, S. M.; Sun, G.; Herold, M. J.; Polo, J. M.; Bellgrove, M. A.; Hawi, Z.

10.1101/2022.04.12.488094 — genetics — Posted on 2022-04-13

2108 From individual behaviors to collective outcomes: fruiting body formation in Dictyostelium as a group-level phenotype

Kuzdzal-Fick, J. J.; Moreno, A.; Broersma, C. M.; Cooper, T. F.; Ostrowski, E. A.

10.1101/2022.04.12.487948 — evolutionary biology — Posted on 2022-04-13

2109 Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals

Braun, K. M.; Haddock, L. A.; Crooks, C. M.; Barry, G. L.; Lalli, J.; Neumann, G.; Watanabe, T.; Imai, M.; Yamayoshi, S.; Ito, M.; Kawaoka, Y.; Friedrich, T. C.

10.1101/2022.04.12.488056 — microbiology — Posted on 2022-04-13

2110 Carbon dioxide regulates Mycobacterium tuberculosis PhoPR signaling and virulence

Dechow, S. J.; Goyal, R.; Johnson, B. K.; Abramovitch, R. B.

10.1101/2022.04.12.488064 — microbiology — Posted on 2022-04-13

2111 Axonal plasticity in response to active forces generated through magnetic nano-pulling

Falconieri, A.; De Vincentiis, S.; Cappello, V.; Convertino, D.; Ghignoli, S.; Figoli, S.; Luin, S.; Catala-Castro, F.; Marchetti, L.; Borello, U.; Krieg, M.; Raffa, V.

10.1101/2022.04.12.487762 — neuroscience — Posted on 2022-04-13

2112 Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex

Voigts, J.; Kanitscheider, I.; Miller, N. J.; Toloza, E. H.; Newman, J. P.; Fiete, I. R.; Harnett, M. T.

10.1101/2022.04.12.488024 — neuroscience — Posted on 2022-04-13

2113 Estimating Brain Functional Connectivity from Common Subspace Mapping Between Structural and Functional Connectomes

Ghosh, S.; Raj, A.; Nagarajan, S.

10.1101/2022.04.12.488055 — neuroscience — Posted on 2022-04-13

2114 Optimal enzyme utilization suggests concentrations and thermodynamics favor condition-specific saturations and binding mechanisms

Sahin, A.; Weilandt, D.; Hatzimanikatis, V.

10.1101/2022.04.12.488028 — systems biology — Posted on 2022-04-13

2115 Mutation of Arabidopsis SME1 and Sm core assembly improves oxidative stress resilience

Willems, P.; Van Ruyskensvelde, V.; Maruta, T.; Pottie, R.; Fernandez-Fernandez, A. D.; Pauwels, J.; Hannah, M. A.; Gevaert, K.; Van Breusegem, F.; Van Der Kelen, K.

10.1101/2022.04.12.488072 — plant biology — Posted on 2022-04-13

2116 Identification of two bZIP transcription factors that regulate development of pavement and trichome cells in Arabidopsis thaliana by single-cell RNA-sequencing

Wu, R.; Liu, Z.; Wang, J.; Li, W.; Qin, A.; Yu, X.; Liu, H.; Guo, C.; Zhao, Z.; Zhang, Y.; Zhou, Y.; Sun, S.; Liu, Y.; Hu, M.; Yang, J.; Jan, M.; Bawa, G.; Rochaix, J.-D.; An, G. Y.; Herrera-Estrella, L.; Tran, L.-S. P.; Sun, X.

10.1101/2022.04.12.488054 — plant biology — Posted on 2022-04-13

2117 Inflammation induced Vascular Smooth Muscle Cell expressing Angiopoietin-like 2 to promote the development of abdominal aortic aneurysm

Yang, G.; Guo, J.; Wu, S.; Yu, H.

10.1101/2022.04.12.488011 — pathology — Posted on 2022-04-13

2118 3D-equivariant graph neural networks for protein model quality assessment

Chen, C.; Chen, X.; Morehead, A.; Wu, T.; Cheng, J.

10.1101/2022.04.12.488060 — bioinformatics — Posted on 2022-04-13

2119 Fiber orientation downsampling compromises the computation of white matter tract-related deformation

Zhou, Z.; Wang, T.; Jorgens, D.; Li, X.

10.1101/2021.12.07.471622 — bioengineering — Posted on 2022-04-13

2120 When blue turns to grey - Paleogenomic insights into the evolutionary history and extinction of the blue antelope (Hippotragus leucophaeus)

Hempel, E.; Bibi, F.; Faith, J. T.; Koepfli, K.-P.; Klittich, A. M.; Duchene, D. A.; Brink, J. S.; Kalthoff, D. C.; Dalen, L.; Hofreiter, M.; Westbury, M. V.

10.1101/2022.04.12.487785 — evolutionary biology — Posted on 2022-04-13

2121 Climatic niche conservatism and ecological diversification in the Holarctic cold-dwelling butterfly genus Erebia

Kleckova, I.; Klecka, J.; Fric, Z. F.; Cesanek, M.; Dutoit, L.; Pellissier, L.; Maravi, P. M.

10.1101/2022.04.12.488065 — evolutionary biology — Posted on 2022-04-13

2122 Coupling phenotype stability to growth rate overcomes limitations of bet-hedging strategies

de Groot, D. H.; Tjalma, A. J.; Bruggeman, F. J.; van Nimwegen, E.

10.1101/2022.04.12.488059 — evolutionary biology — Posted on 2022-04-13

2123 BirdFlow: Learning Seasonal Bird Movements from Citizen Science Data

Fuentes, M.; Van Doren, B.; Fink, D.; Sheldon, D.

10.1101/2022.04.12.488057 — ecology — Posted on 2022-04-13

2124 Carbohydrates complement high protein diets to maximize the growth of an actively hunting predator

Wiggins, W. d.; Wilder, S.

10.1101/2022.04.12.487891 — ecology — Posted on 2022-04-13

2125 Light targeting the melanopic system suppresses melatonin, but does not alter sleepiness, vigilance, sensory processing, or sleep

Blume, C.; Niedernhuber, M.; Spitschan, M.; Slawik, H. C.; Meyer, M. P.; Bekinschtein, T.; Cajochen, C.

10.1101/2022.04.12.488023 — neuroscience — Posted on 2022-04-13

Herrmann, B.; Maess, B.; Henry, M. J.; Obleser, J.; Johnsrude, I. S.

10.1101/2022.04.12.487991 — neuroscience — Posted on 2022-04-13

2127 Deep Brain Magnetothermal Silencing of Dopaminergic Neurons via Endogenous TREK1 Channels Abolishes Place Preference in Mice

Liu, J.; Munshi, R.; He, M.; Parker, S.; Pralle, A.

10.1101/2022.04.12.487994 — neuroscience — Posted on 2022-04-13

2128 Speech prosody supports speaker selection and auditory stream segregation in a multi-talker situation

Kovacs, P.; Toth, B.; Honbolygo, F.; Szalardy, O.; Kohari, A.; Mady, K.; Magyari, L.; Winkler, I.

10.1101/2022.04.12.487484 — neuroscience — Posted on 2022-04-13

2129 Astrocyte-mediated transduction of muscle fiber contractions synchronizes hippocampal neuronal network development

Lee, K. Y.; Rhodes, J. S.; Saif, M. T. A.

10.1101/2022.04.12.487995 — neuroscience — Posted on 2022-04-13

2130 Gestational Ethanol Exposure Induces Sex-specific Striatal Acetylcholine and Dopamine Deficits

Bariselli, S.; Mateo, Y.; Reuveni, N.; Lovinger, D. M.

10.1101/2022.04.12.488031 — neuroscience — Posted on 2022-04-13

2131 Two stages of bandwidth scaling drives efficient neural coding of natural sounds

He, F.; Stevenson, I. H.; Escabi, M. A.

10.1101/2022.04.12.488076 — neuroscience — Posted on 2022-04-13

2132 Modulation of Arabidopsis growth by volatile organic compounds from a root-derived bacterial community

Türksoy, G. M.; Carron, R.; Koprivova, A.; Kopriva, S.; Wippel, K.; Andersen, T. G.

10.1101/2022.04.12.488003 — plant biology — Posted on 2022-04-13

2133 Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing DEG/ENaCs

Kaulich, E.; McCubbin, P. T.; Schafer, W.; Walker, D.

10.1101/2022.04.12.488049 — physiology — Posted on 2022-04-13

2134 Cell-free, methylated DNA in blood samples reveals tissue-specific, cellular damage from radiation treatment

10.1101/2022.04.12.487966 — cancer biology — Posted on 2022-04-13

2135 The adapted Activity-By-Contact model for enhancer-gene assignment and its application to single-cell data

Hecker, D.; Behjati Ardakani, F.; Schulz, M. H.

10.1101/2022.01.28.478202 — bioinformatics — Posted on 2022-04-13

2136 Proximal Exploration for Model-guided Protein Sequence Design

Ren, Z.; Li, J.; Ding, F.; Zhou, Y.; Ma, J.; Peng, J.

10.1101/2022.04.12.487986 — bioinformatics — Posted on 2022-04-13

2137 Inverse Material Parameter Estimation of Patient Specific Finite Element Models at the Carotid Bifurcation: The Impact of Excluding the Zero Pressure Configuration and Residual Stress

Johnston, R. D.; Ghasemi, M.; Lally, C.

10.1101/2022.04.12.487823 — bioengineering — Posted on 2022-04-13

2138 A systematic examination of learning in the invasive ant Linepithema humile reveals very rapid development of short and long-term memories

Wagner, T.; Galante, H.; Czaczkes, T. J.

10.1101/2022.04.12.487867 — animal behavior and cognition — Posted on 2022-04-13

2139 Differential gene expression underlying the biosynthesis of Dufour's gland signals in Bombus impatiens

Derstine, N.; Galbraith, D.; Villar, G.; Amsalem, E.

10.1101/2022.04.12.488013 — genomics — Posted on 2022-04-13

2140 An updated C. elegans body muscle transcriptome for studies in muscle formation and function

Schorr, A. L.; Mejia, A. F.; Miranda, M. Y.; Mangone, M.

10.1101/2022.04.12.488068 — genetics — Posted on 2022-04-13

2141 A nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells

Taiber, S.; Gozlan, O.; Cohen, R.; Andrade, L. R.; Gregory, E. F.; Starr, D. A.; Moran, Y.; Hipp, R.; Kelley, M. W.; Manor, U.; Sprinzak, D.; Avraham, K. B.

10.1101/2021.10.10.463824 — cell biology — Posted on 2022-04-13

2142 Stably bound adaptor proteins modulate directionality of RNP transport

Phea, L. J.; Ephrussi, A.

10.1101/2022.04.12.487826 — cell biology — Posted on 2022-04-13

2143 Orchestrated Restructuring Events During Secretory Granule Maturation Mediate Intragranular Cargo Segregation

Syed, Z. A.; Zhang, L.; Tran, D. T.; Bleck, C. K. E.; Ten Hagen, K. G.

10.1101/2021.08.16.456250 — cell biology — Posted on 2022-04-13

2144 Representation of illusory shapes within the topographic areas of the posterior parietal cortex

Arsenovic, A.; Ischebeck, A.; Zaretskaya, N.

10.1101/2022.04.12.488016 — neuroscience — Posted on 2022-04-13

2145 Binding of different substrate molecules at the docking site and the active site of γ-secretase can trigger toxic events in sporadic and familial Alzheimer's disease

Svedruzic, Z. M.; Sendula-Jengic, V.; Ostojic, L.

10.1101/2022.04.12.487996 — neuroscience — Posted on 2022-04-13

2146 Calibration allows accurate estimation of the axonal volume fraction with diffusion MRI

Papazoglou, S.; Ashtarayeh, B.; Oeschger, M.; Callaghan, M. F.; Does, M. D.; Mohammadi, S.

10.1101/2022.04.12.488014 — neuroscience — Posted on 2022-04-13

2147 Control and coding of pupil size by hypothalamic orexin neurons

Grujic, N.; Tesmer, A.; Bracey, E. F.; Peleg-Raibstein, D.; Burdakov, D.

10.1101/2022.04.12.488026 — neuroscience — Posted on 2022-04-13

2148 Pectin remodeling belongs to a homeostatic system and triggers transcriptomic and hormonal modulations

Jobert, F.; Guenin, S.; Voxeur, A.; Lee, K. J.; Bouton, S.; Senechal, F.; Hocq, L.; Mongelard, G.; Demailly, H.; Amakorova, P.; Strnad, M.; Vernhettes, S.; Mouille, G.; Pilard, S.; Knox, P.; Novak, O.; Pelloux, J.; Gutierrez, L.

10.1101/2021.07.22.453319 — plant biology — Posted on 2022-04-13

2149 Genotype-dependent responses to long-term water stress in Chenopodium quinoa Willd

Maestro-Gaitan, I.; Granado-Rodriguez, S.; Orus, M. I.; Matias Prieto, J.; Cruz Sobrado, V.; Bolanios Rosa, L.; Reguera, M.

10.1101/2022.04.12.488037 — plant biology — Posted on 2022-04-13

2150 Machine learning-assisted fluoroscopy of bladder function in awake mice

De Bruyn, H.; Corthout, N.; Munck, S.; Everaerts, W.; Voets, T.

10.1101/2022.04.12.488006 — physiology — Posted on 2022-04-13

2151 Deciphering the mRNA-lncRNA-miRNA interaction landscape in human pluripotency

Ghosh, A.; Som, A.

10.1101/2022.04.12.488044 — bioinformatics — Posted on 2022-04-13

2152 Plasmid stability in fluctuating environments:population genetics of multi-copy plasmids

Miro Pina, V.; Hernandez-Beltran, J. C. R.; Siri-Jegousse, A.; Palau, S.; Pena-Miller, R.; Gonzalez-Casanova, A.

10.1101/2022.03.15.484385 — evolutionary biology — Posted on 2022-04-13

2153 Aerobic glycolysis is important for zebrafish larval wound closure and tail regeneration

Scott, C. A.; Carney, T. J.; Amaya, E.

10.1101/2021.04.23.441208 — developmental biology — Posted on 2022-04-13

2154 Modelling rheumatoid arthritis: A hybrid modelling framework to describe pannus formation in a small joint

Chaplain, M. A.; Eftimie, R.; Macfarlane, F.

10.1101/2021.09.02.458714 — immunology — Posted on 2022-04-13

2155 Genetically-Modified Macrophages Accelerate Myelin Repair

Aigrot, M.-S.; Barthelemy, C.; Moyon, S.; Dufayet-Chaffaud, G.; Izagirre-Urizar, L.; Gillet-Legrand, B.; Tada, S.; Bayon-Cordero, L.; Chara, J.-C.; Matute, C.; Cartier, N.; Lubetzki, C.; Tepavcevic, V.

10.1101/2020.10.28.358705 — neuroscience — Posted on 2022-04-13

2156 Medial prefrontal-hippocampal concordance in child-parent dyads underlies children's psychological wellbeing

Su, H.; Young, C. B.; Han, Z. R.; Xu, J.; Xiong, B.; Wang, J.; Hao, L.; Yang, Z.; Chen, G.; Qin, S.

10.1101/2022.03.30.486310 — neuroscience — Posted on 2022-04-13

2157 Complete microglia deficiency accelerates prion disease without enhancing CNS prion accumulation

Bradford, B. M.; McGuire, L. A.; Pridans, C.; Hume, D. A.; Mabbott, N. A.

10.1101/2021.01.05.425436 — neuroscience — Posted on 2022-04-13

2158 spongEffects: ceRNA modules offer patient-specific insights into the miRNA regulatory landscape

Boniolo, F.; Hoffmann, M.; Roggendorf, N.; Tercan, B.; Baumbach, J.; Castro, M.; Robertson, A. G.; Saur, D.; List, M.

10.1101/2022.03.29.486212 — systems biology — Posted on 2022-04-13

2159 A stepwise route to domesticate rice by controlling seed shattering and panicle shape

Ishikawa, R.; Castillo, C. C.; Htun, T. M.; Numaguchi, K.; Inoue, K.; Oka, Y.; Ogasawara, M.; Sugiyama, S.; Takama, N.; Orn, C.; Inoue, C.; Nonomura, K.-i.; Allaby, R. G.; Fuller, D. Q.; Ishii, T.

10.1101/2021.12.02.470680 — plant biology — Posted on 2022-04-13

2160 DiSCERN - Deep Single Cell Expression ReconstructioN for improved cell clustering and cell subtype and state detection

Hausmann, F.; Ergen, C.; Khatri, R.; Marouf, M.; Hänzelmann, S.; Gagliani, N.; Huber, S.; Machart, P.; Bonn, S.

10.1101/2022.03.09.483600 — bioinformatics — Posted on 2022-04-13

2161 BatchDTA: Implicit batch alignment enhances deep learning-based drug-target affinity estimation

Luo, H.; Xiang, Y.; Fang, X.; Lin, W.; Wang, F.; Wu, H.; Wang, H.

10.1101/2021.11.23.469641 — bioinformatics — Posted on 2022-04-13

2162 Novel MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine

Fets, L.; Bevan, N.; Nunes, P. M.; Campos, S.; Silva dos Santos, M.; Sherriff, E. B.; MacRae, J. I.; House, D.; Anastasiou, D.

10.1101/2021.03.15.433711 — biochemistry — Posted on 2022-04-13

2163 Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores

Prive, F.; Arbel, J.; Aschard, H.; Vilhjalmsson, B. J.

10.1101/2021.03.29.437510 — genetics — Posted on 2022-04-13

2164 Joint analysis of microsatellites and flanking sequences enlightens complex demographic history of interspecific gene flow and vicariance in rear-edge oak populations.

Olivier, L.; Aissi, A.; Vela, E.; Beghami, Y.

10.1101/2021.07.12.452011 — evolutionary biology — Posted on 2022-04-13

2165 Mosaic and non-mosaic pcdh19 mutation leads to neuronal hyperexcitability in zebrafish

Robens, B. K.; Yang, X.; McGraw, C. M.; Turner, L. H.; Robens, C.; Thyme, S.; Rotenberg, A.; Poduri, A.

10.1101/2021.09.03.458732 — neuroscience — Posted on 2022-04-13

2166 Frequency modulated timer regulates mammalian hibernation

Gibo, S.; Yamaguchi, Y.; Kurosawa, G.

10.1101/2021.11.12.468369 — zoology — Posted on 2022-04-13

2167 A flexible method for estimating tip diversification rates across a range of speciation and extinction scenarios

Vasconcelos, T.; O'Meara, B. C.; Beaulieu, J. M.

10.1101/2021.11.02.466977 — evolutionary biology — Posted on 2022-04-13

2168 Proteomic study of differentially expressed proteins in seeds between parents and offspring of castor bean (Ricinus communis L.)

Xiaotian, L.; Rui, L.; Yanxin, Z.; Mingda, Y.; Yanpeng, W.; Xuemei, H.; Zhiyan, W.; Yumiao, H.; Fenglan, H.

10.1101/2022.04.13.488138 — molecular biology — Posted on 2022-04-13

2169 Titers of antibodies the receptor-binding domain (RBD) of ancestral SARS-CoV-2 are predictive for levels of neutralizing antibodies to multiple variants

Tran, T. T.; Vaage, E. B.; Mehta, A.; Chopra, A.; Kolderup, A.; Anthi, A. K.; Konig, M.; Nygard, G.; Lind, A.; Muller, F.; Nissen-Meyer, L. S. H.; Magnus, P.; Trogstad, L.-I. S.; Mjaaland, S.; Soraas, A.; Midtvedt, K.; Aasberg, A.; Barratt-Due, A.; Medhus, A. W.; Hoivik, M. L.; Lundin, K. E. A.; Karlsen, R. F.; Dahle, R.; Danielsson, K.; Thomassen, K. S.; Birkeland Kro, G.; Cox, R. J.; Zhou, F.; Langeland, N.; Aukrust, P.; Melum, E.; Avitsland, T. L.; Wiencke, K.; Holter, J. C.; Munthe, L. A.; Grodeland, G.; Andersen, J. T.; Vaage, J. T.; Lund-Johansen, F.

10.1101/2022.03.26.484261 — immunology — Posted on 2022-04-13

2170 Admp regulates tail bending by controlling ventral epidermal cell polarity via phosphorylated myosin translocation.

Kogure, Y. S.; Muraoka, H.; Koizumi, W. C.; Gelin-alessi, R.; Godard, B.; Heisenberg, C.-P.; Oka, K.; Hotta, K.

10.1101/2021.09.21.461063 — developmental biology — Posted on 2022-04-12

2171 Cryo-EM structure of an atypical proton-coupled peptide transporter: Di- and tripeptide permease C

Killer, M.; Finocchio, G.; Mertens, H.; Svergun, D. I.; Pardon, E.; Steyaert, J.; Loew, C.

10.1101/2022.04.12.487992 — biophysics — Posted on 2022-04-12

2172 Weighted Kernels Improve Multi-Environment Genomic Prediction

Hu, X.; Carver, B. F.; El-Kassaby, Y. A.; Zhu, L.; Chen, C.

10.1101/2022.04.10.487783 — bioinformatics — Posted on 2022-04-12

2173 A chromosome-level assembly of the "Cascade" hop (Humulus lupulus) genome uncovers signatures of molecular evolution and improves time of divergence estimates for the Cannabaceae family

Padgitt-Cobb, L. K.; Pitra, N. J.; Matthews, P. D.; Henning, J. A.; Hendrix, D. A.

10.1101/2022.03.24.485698 — genomics — Posted on 2022-04-12

2174 Unifying Transcriptome Regulation and Cellular Operational Efficiency: Application of the Locality and Caching Principles via a Cell-to-Computer Analogy

Jiang, W.; Feliers, D.; Zheng, W. J.; Zhang, F.; Wang, D.

10.1101/2022.01.11.475967 — systems biology — Posted on 2022-04-12

2175 Cryo-EM structure of an atypical proton-coupled peptide transporter: Di- and tripeptide permease C

Loew, C.; Killer, M.; Mertens, H.; Svergun, D. I.; Pardon, E.; Steyaert, J.; Finocchio, G.

10.1101/2022.04.12.487992 — biophysics — Posted on 2022-04-12

2176 Spatially coherent diffusion of human RNA Pol II depends on transcriptional state rather than chromatin motion

Barth, R.; Shaban, H. A.

10.1101/2022.01.19.476954 — biophysics — Posted on 2022-04-12

2177 DeepDrug: A general graph-based deep learning framework for drug-drug interactions and drug-target interactions prediction

Yin, Q.; Cao, X.; Fan, R.; Liu, Q.; Jiang, R.; Zeng, W.

10.1101/2020.11.09.375626 — bioinformatics — Posted on 2022-04-12

2178 A streamlined tandem tip-based workflow for sensitive nanoscale phosphoproteomics

Tsai, C.-F.; Wang, Y.-T.; Hsu, C.-C.; Kitata, R. B.; Chu, R. K.; Velickovic, M.; Zhao, R.; Williams, S. M.; Chrisler, W. B.; Jorgensen, M. L.; Moore, R. J.; Zhu, Y.; Rodland, K. D.; Smith, R. D.; Wasserfall, C. H.; Shi, T.; Liu, T.

10.1101/2022.04.12.488038 — biochemistry — Posted on 2022-04-12

2179 pSNAP: Proteome-wide analysis of elongating nascent polypeptide chains

Uchiyama, J.; Roy, R.; Wang, D. O.; Morikawa, K.; Kawahara, Y.; Iwasaki, M.; Yoshino, C.; Mishima, Y.; Ishihama, Y.; Imami, K.

10.1101/2021.09.22.461445 — biochemistry — Posted on 2022-04-12

2180 Assessment of AI-based Protein Structure Prediction for the NLRP3 Target

Yin, J.; Yu, J.; Lei, J.; Cui, W.; Satz, A. L.; Zhou, Y.; Feng, H.; Deng, J.; Su, W.; Kuai, L.

10.1101/2021.11.05.467381 — biochemistry — Posted on 2022-04-12

2181 A chromosome-scale genome assembly of a Bacillus thuringiensis Cry1Ac insecticidal protein resistant strain of Helicoverpa zea

Stahlke, A. R.; Chang, J.; Tembrock, L. R.; Sim, S. B.; Chudalayandi, S.; Geib, S. M.; Scheffler, B. R.; Perera, O. P.; Gilligan, T. M.; Childers, A. K.; Hackett, K. J.; Coates, B. S.

10.1101/2022.04.12.488070 — genomics — Posted on 2022-04-12

2182 Human and murine Cryptococcus neoformans infection selects for common genomic changes in an environmental isolate.

Sephton-Clark, P.; McConnell, S. A.; Grossman, N.; Baker, R.; Dragotakes, Q.; Fan, Y.; Fu, M. S.; Gerbig, G.; Greengo, S.; Hardwick, J. M.; Kulkarni, M.; Levitz, S. M.; Nosanchuk, J. D.; Shoham, S.; Smith, D.; Stempinski, P.; Wear, M.; Cuomo, C. A.; Casadevall, A.

10.1101/2022.04.12.487930 — genomics — Posted on 2022-04-12

2183 Long-term balancing selection and the genetic load linked to the self-incompatibility locus in Arabidopsis halleri and A. lyrata.

Le Veve, A.; Burghgraeve, N.; Genete, M.; Lepers-Blassiau, C.; Takou, M.; De Meaux, J.; Mable, B. K.; Durand, E.; Vekemans, X.; Castric, V.

10.1101/2022.04.12.487987 — genomics — Posted on 2022-04-12

2184 Viral origin of eukaryotic type IIA DNA topoisomerases

Guglielmini, J.; Gaia, M.; Da Cunha, V.; Criscuolo, A.; Krupovic, M.; Forterre, P.

10.1101/2022.04.12.488027 — evolutionary biology — Posted on 2022-04-12

2185 Plant-host shift, spatial persistence, and the viability of an invasive insect population

Bueno Silva, I.; McGrane-Corrigan, B.; Mason, O.; de Andrade Moral, R.; Augusto Conde Godoy, W.

10.1101/2021.09.20.461112 — ecology — Posted on 2022-04-12

2186 An Inhibitory Function of TRPA1 Channels in TGF-β1-driven Fibroblast to Myofibroblast Differentiation

Geiger, F.; Zeitlmayr, S.; Staab-Weijnitz, C. A.; Rajan, S.; Breit, A.; Gudermann, T.; Dietrich, A.

10.1101/2022.04.12.488008 — cell biology — Posted on 2022-04-12

2187 Supramolecular architecture of the ER-mitochondria encounter structure in its native environment

Wozny, M. R.; Di Luca, A.; Morado, D. R.; Picco, A.; Hoffmann, P. C.; Miller, E. A.; Vanni, S.; Kukulski, W.

10.1101/2022.04.12.488000 — cell biology — Posted on 2022-04-12

2188 The cellular poly(rC)-binding protein 2 prevents the early steps of hepatitis C virus virion assembly

Cousineau, S. E.; Sagan, S. M.

10.1101/2022.04.12.488029 — molecular biology — Posted on 2022-04-12

2189 Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5

Clasen, S. J.; Bell, M. E.; Lee, D.; Henseler, Z.; Borbon, A.; de la Cuesta-Zuluaga, J.; Parys, K.; Zou, J.; Youngblut, N. D.; Gewirtz, A. T.; Belkhadir, Y.; Ley, R. E.

10.1101/2022.04.12.488020 — microbiology — Posted on 2022-04-12

2190 Proteolytic Analysis of Epsilon 34 Phage Tailspike protein indicates Partial Sensitivity to Proteinase K

Ayariga, J. A.; Villafane, R.

10.1101/2022.04.12.488085 — microbiology — Posted on 2022-04-12

2191 Performance of novel antibodies for lipoarabinomannan to develop diagnostic tests for Mycobacterium tuberculosis

Cantera, J. L.; Lillis, L. M.; Peck, R. B.; Moreau, E.; Schouten, J. A.; Davis, P.; Drain, P. K.; Andama, A.; Pinter, A.; Kawasaki, M.; Kallenius, G.; Sundling, C.; Dobos, K. M.; Flores, D.; Chatterjee, D.; Murphy, E.; Halas, O. R.; Boyle, D. S.

10.1101/2022.04.12.488063 — microbiology — Posted on 2022-04-12

2192 Selective B cell depletion upon intravenous infusion of replication-incompetent anti-CD19 CAR lentivirus

Rive, C. M.; Yung, E.; Dreolini, L.; Brown, S. D.; May, C. G.; Woodsworth, D. J.; Holt, R. A.

10.1101/2020.05.15.098335 — immunology — Posted on 2022-04-12

2193 A dopamine-dependent decrease in dorsomedial striatum direct pathway neuronal activity is required for learned motor coordination

Cataldi, S.; Lacefield, C.; N, S.; Kumar, G.; Sulzer, D.

10.1101/2021.06.07.447452 — neuroscience — Posted on 2022-04-12

2194 Typical hippocampal transcriptional response across estrous is dysregulated by Cnih3 gene deletion

Mulvey, B.; Frye, H. E.; Lintz, T.; Fass, S.; Tycksen, E.; Nelson, E. C.; Moron, J. A.; Dougherty, J.

10.1101/2022.04.11.487915 — neuroscience — Posted on 2022-04-12

2195 Bidirectional Control of Parathyroid Hormone and Bone Mass by Subfornical Organ

Zhang, L.; Liu, N.; Shao, J.; Gao, D.; Liu, Y.; Chen, D.; Wang, L.; Lu, W. W.; Yang, F.

10.1101/2020.11.30.403279 — neuroscience — Posted on 2022-04-12

2196 Hit-and-run silencing of endogenous DUX4 by targeting DNA hypomethylation on D4Z4 repeats in facioscapulohumeral muscular dystrophy

Sasaki-Honda, M.; Jonouchi, T.; Arai, M.; He, J.; Okita, K.; Sakurai, S.; Yamamoto, T.; Sakurai, H.

10.1101/2022.04.12.487997 — pathology — Posted on 2022-04-12

2197 Neurogenesis and angiogenesis are associated features of aggressive breast cancer

Wik, E.; Aziz, S.; Vethe, H.; Askeland, C.; Finne, K.; Knutsvik, G.; Winge, I.; Kruger, K.; Svanoe, A. A.; Birkeland, E.; Kjolle, S.; Davidsen, B.; Aas, T.; Stefansson, I. M.; Kleftogiannis, D.; Akslen, L. A.

10.1101/2022.01.28.477898 — cancer biology — Posted on 2022-04-12

2198 Mechanism of homotropic cooperativity from nearest-neighbor statistical thermodynamic modelling and native mass spectrometry of ring-shaped homo-oligomeric ligand binding proteins

Li, W.; Norris, A. S.; Lichtenthal, K.; Kelly, S.; Ihms, E. C.; Gollnick, P.; Wysocki, V. H.; Foster, M. P.

10.1101/2022.03.19.484990 — biophysics — Posted on 2022-04-12

2199 Exploring generality of experimental conformational changes with AlphaFold predictions

Castellvi, A.; Medina, A.; Petrillo, G.; Sagmeister, T.; Pavkov-Keller, T.; Govantes, F.; Diederichs, K.; Sammito, M. D.; Uson, I.

10.1101/2022.04.12.488086 — biophysics — Posted on 2022-04-12

2200 Individual activator and repressor transcription factors induce global changes in chromatin mobility

SHABAN, H. A.; Suter, D. M.

10.1101/2022.04.12.488001 — biophysics — Posted on 2022-04-12

2201 Microbial Species Abundance Distributions Guide Human Population Size Estimation from Sewage Microbiomes

Zhang, L.; Chen, L.; Yu, X.; Duvallet, C.; Isazadeh, S.; Dai, C.; Park, S.; Frois-Moniz, K.; Duarte, F.; Ratti, C.; Alm, E. J.; Ling, F.

10.1101/2020.12.15.390716 — bioinformatics — Posted on 2022-04-12

2202 Systematic in silico discovery of novel solute carrier-like proteins from proteomes

Gyimesi, G.; Hediger, M. A.

10.1101/2021.11.19.469292 — bioinformatics — Posted on 2022-04-12

2203 Expanding adult tubular microvessels on stiff substrates with endothelial cells and pericytes from the same tissue

Song, X.; Yu, Y.; Mu, J.; Wang, Z.; Leng, Y.; Xu, Y.; Zhu, H.; Qiu, X.; Li, P.; Li, J.; Wang, D.

10.1101/2022.04.12.488033 — bioengineering — Posted on 2022-04-12

2204 Base editor scanning charts the DNMT3A activity landscape

Lue, N. Z.; Garcia, E. M.; Ngan, K. C.; Lee, C.; Doench, J. G.; Liau, B. B.

10.1101/2022.04.12.487946 — biochemistry — Posted on 2022-04-12

2205 Monitoring extracellular ion and metabolite dynamics with recombinant nanobody-fused biosensors

Burgstaller, S.; Wagner, T. R.; Bischof, H.; Bueckle, S.; Padamsey, A.; Frecot, D. I.; Kaiser, P. D.; Skrabak, D.; Malli, R.; Lukowski, R.; Rothbauer, U.

10.1101/2022.04.12.488002 — biochemistry — Posted on 2022-04-12

2206 Goldilocks calcium and the mitochondrial respiratory chain: too much, too little, just right

Vilas-Boas, E. A.; Cabral-Costa, J. V.; Ramos, V. M.; Caldeira da Silva, C. C.; Kowaltowski, A. J.

10.1101/2022.04.12.488015 — biochemistry — Posted on 2022-04-12

2207 Tuning aromatic contributions by site-specific encoding of fluorinated phenylalanine residues in bacterial and mammalian cells

Galles, G. D.; Infield, D. T.; Clark, C. J.; Manikandan, S.; Rasouli, A.; Tajkhorshid, E.; Galpin, J. D.; Cooley, R. B.; Mehl, R. A.; Ahern, C. A.

10.1101/2022.04.12.488046 — biochemistry — Posted on 2022-04-12

2208 Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing

Katsman, E.; Orlanski, S.; Martignano, F.; Fox-Fisher, I.; Shemer, R.; Dor, Y.; Zick, A.; Eden, A.; Petrini, I.; Conticello, S. G.; Berman, B. P.

10.1101/2021.10.18.464684 — genomics — Posted on 2022-04-12

2209 Karyorelict ciliates use an ambiguous genetic code with context-dependent stop/sense codons

Seah, B. K. B.; Singh, A.; Swart, E.

10.1101/2022.04.12.488043 — genomics — Posted on 2022-04-12

2210 Phylogenomics and body shape morphometrics reveal recent origin and diversification in the goatfishes (Syngnatharia: Mullidae)

Nash, C. M.; Lungstrom, L. L.; Hughes, L. C.; Westneat, M. W.

10.1101/2022.04.12.488079 — evolutionary biology — Posted on 2022-04-12

2211 The SNARE Sec22b regulates phagosome maturation by promoting ORP8-mediated PI(4)P exchange at ER-phagosome contact sites.

Criado Santos, N.; Bouvet, S.; Bermont, F.; Castelbou, C.; Mansour, F.; Azam, M.; Giordano, F.; Nunes-Hasler, P.

10.1101/2022.04.12.487993 — cell biology — Posted on 2022-04-12

2212 Piezo mechanosensory channels regulate centrosome integrity

David, L.; Martinez, L.; Xi, Q.; Fan, X.; Kooshesh, K. A.; Zhang, Y.; Shah, J. V.; Lu, W.; Maas, R. L.; Wu, H.

10.1101/2022.04.12.488050 — cell biology — Posted on 2022-04-12

2213 Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage

Azad, K.; Guilligay, D.; Boscheron, C.; Maity, S.; De Franceschi, N.; Sulbaran, G.; Effantin, G.; Wang, H.; Kleman, J.-P.; Bassereau, P.; Schoehn, G.; Roos, W.; Desfosses, A.; Weissenhorn, W.

10.1101/2022.04.12.487901 — cell biology — Posted on 2022-04-12

2214 High levels of cyclic diguanylate interfere with beneficial bacterial colonization

Isenberg, R. Y.; Christensen, D. G.; Visick, K. L.; Mandel, M. J.

10.1101/2022.04.11.487973 — microbiology — Posted on 2022-04-12

2215 A recombinant murine rotavirus with Nano-Luciferase expression reveals tissue tropism, replication dynamics, and virus transmission

Zhu, Y.; Sanchez-Tacuba, L.; Hou, G.; Kawagishi, T.; Feng, N.; Greenberg, H. B.; Ding, S.

10.1101/2022.04.12.488073 — microbiology — Posted on 2022-04-12

2216 EstG is a novel esterase required for cell envelope integrity

Daitch, A. K.; Orsburn, B. C.; Chen, Z.; Alvarez, L.; Eberhard, C. D.; Sundararajan, K.; Zeinert, R.; Kreitler, D. F.; Jakoncic, J.; Chien, P.; Cava, F.; Gabelli, S. B.; Bumpus, N. N.; Goley, E. D.

10.1101/2022.04.12.488081 — microbiology — Posted on 2022-04-12

2217 Heterotypic Influenza Infections Mitigate Susceptibility to Secondary Bacterial Infection

Cipolla, E. M.; Yue, M.; Nickolich, K. L.; Huckestein, B. R.; Antos, D. E.; Chen, W.; Alcorn, J. F.

10.1101/2022.04.12.488032 — immunology — Posted on 2022-04-12

2218 The C-type Lectin Receptor Dectin-2 is a receptor for Aspergillus fumigatus galactomannan

Reedy, J. L.; Crossen, A. J.; Negoro, P. E.; Brown, H. E.; Ward, R. A.; Blanco, D. A. V.; Timmer, K. D.; Mansour, M. K.; Wüthrich, M.; Fontaine, T.; Latgé, J.-P.; Vyas, J. M.

10.1101/2022.04.12.488040 — immunology — Posted on 2022-04-12

2219 Model evolution in SARS-CoV-2 spike protein sequences using a generative neural network

Kumar, A.

10.1101/2022.04.12.487999 — bioinformatics — Posted on 2022-04-12

2220 Purification and Characterization of Inorganic Pyrophosphatase for in vitro RNA Transcription

Tersteeg, S.; Mrozowich, T.; Henrickson, A.; Demeler, B.; Patel, T. R.

10.1101/2022.04.12.488088 — biochemistry — Posted on 2022-04-12

2221 Immotile cilia of the mouse node sense a fluid flow-induced mechanical force for left-right symmetry breaking

Katoh, T. A.; Omori, T.; Mizuno, K.; Sai, X.; Minegishi, K.; Ikawa, Y.; Nishimura, H.; Itabashi, T.; Kajikawa, E.; Hiver, S.; Iwane, A. H.; Ishikawa, T.; Okada, Y.; Nishizaka, T.; Hamada, H.

10.1101/2022.04.11.487968 — developmental biology — Posted on 2022-04-12

2222 Modeling tactile pleasantness across skin types at the individual level reveals a reliable and stable basic function

Crucianelli, L.; Chancel, M.; Ehrsson, H. H.

10.1101/2022.04.11.487838 — neuroscience — Posted on 2022-04-12

2223 Spatial Models of Pattern Formation During Phagocytosis

Herron, J. C.; Hu, S.; Liu, B.; Watanabe, T.; Hahn, K. M.; Elston, T. C.

10.1101/2022.04.11.487979 — systems biology — Posted on 2022-04-12

2224 Investigating the Consistency of Extracellular Vesicle Production from Breast Cancer Subtypes Using CELLine Adherent Bioreactors

Hisey, C. L.; Artuyants, A.; Guo, G.; Chang, V.; Reshef, G.; Middleditch, M.; Jacob, B.; Chamley, L. W.; Blenkiron, C.

10.1101/2022.04.11.487804 — cancer biology — Posted on 2022-04-12

2225 Scalable production of recombinant three-finger proteins: from inclusion bodies to high quality molecular probes

Xu, J.; Lei, X.; Li, A.; Li, J.; Li, S.; Chen, L.

10.1101/2022.04.11.487962 — biochemistry — Posted on 2022-04-12

2226 Elucidating Mechanisms of Tolerance to Salmonella Typhimurium Across Long-Term Infections Using the Collaborative Cross

Scoggin, K.; Gupta, J.; Lynch, R.; Nagarajan, A.; Aminian, M.; Peterson, A.; Adams, L. G.; Kirby, M.; Threadgill, D.; Andrews-Polymenis, H. L.

10.1101/2022.04.11.487981 — genetics — Posted on 2022-04-12

2227 The admixture histories of Cabo Verde

Laurent, R.; Szpiech, Z. A.; da Costa, S. S.; Thouzeau, V.; Fortes-Lima, C. A.; Dessarps-Freichey, F.; Lemee, L.; Utge, J.; Rosenberg, N. A.; Baptista, M.; Verdu, P.

10.1101/2022.04.11.487833 — genetics — Posted on 2022-04-12

2228 Ribo-macs derived from nucleoli:big ribosome clusters in the cytoplasm of naive stem cells

Qin, K.; Sun, L.; Wu, X.; Wen, J.; Xing, Z.

10.1101/2022.04.11.487846 — developmental biology — Posted on 2022-04-12

2229 Systematic generation and imaging of tandem repeats reveal multivalent base-pairing as a major determinant of RNA aggregation

Isiktas, A. U.; Eshov, A.; Yang, S.; Guo, J. U.

10.1101/2022.04.11.487960 — molecular biology — Posted on 2022-04-12

2230 Metabolic-imaging of human glioblastoma explants: a new precision-medicine model to predict tumor treatment response early

Morelli, M.; Lessi, F.; Barachini, S.; Liotti, R.; Montemurro, N.; Perrini, P.; Santonocito, O. S.; Gambacciani, C.; Snuderl, M.; Pieri, F.; Aquila, F.; Farnesi, A.; Naccarato, A. G.; Viacava, P.; Cardarelli, F.; Ferri, G.; Mulholland, P.; Ottaviani, D.; Paiar, F.; Liberti, G.; Pasqualetti, F.; Menicagli, M.; Aretini, P.; Signore, G.; Franceschi, S.; Mazzanti, C. M.

10.1101/2022.04.12.487679 — molecular biology — Posted on 2022-04-12

2231 Outside-in: intracellular vesicles in giant sulfur bacteria contain peptidoglycan

Flood, B. E.; Leprich, D. J.; Hunter, R. C.; Delherbe, N.; MacGregor, B.; Van Nieuwenhze, M.; Bailey, J. V.

10.1101/2022.04.11.487978 — microbiology — Posted on 2022-04-12

2232 Housekeeping gene gyrA, a potential molecular marker for Bacillus ecology study

Liu, Y.; Stefanic, P.; Miao, Y.; Xue, Y.; Xun, W.; Shen, Q.; Xu, Z.; Zhang, R.; Mulec, I. M.

10.1101/2022.04.11.487959 — microbiology — Posted on 2022-04-12

2233 Highly selective transgene expression through double-floxed inverted orientation system by using a unilateral spacer sequence

Matsushita, N.; Kato, S.; Nishizawa, K.; Sugawara, M.; Takeuchi, K.; Miyasaka, Y.; Mashimo, T.; Kobayashi, K.

10.1101/2022.04.11.487972 — neuroscience — Posted on 2022-04-12

2234 Single sample pathway analysis in metabolomics: performance evaluation and application

Wieder, C.; Lai, R. P.; Ebbels, T.

10.1101/2022.04.11.487976 — bioinformatics — Posted on 2022-04-12

2235 Genome wide screen of RNAi molecules against SARS-CoV-2 creates a broadly potent prophylaxis

Yogev, O.; Weissbrod, O.; Battistoni, G.; Bressan, D.; Naamti, A.; Falciatori, I.; Berkyurek, A. C.; Rasnic, R.; Hosmillo, M.; Ilan, S.; Grossman, I.; McCormick, L.; Honeycutt, C. C.; Johnston, T.; Gagne, M.; Douek, D. C.; Goodfellow, I.; Hannon, G. J.; Erlich, Y.

10.1101/2022.04.12.488010 — genomics — Posted on 2022-04-12

2236 Discrimination of SARS-CoV-2 Omicron sub-lineages BA.1 and BA.2 using a high-resolution melting-based assay: A pilot study

Aoki, A.; Adachi, H.; Mori, Y.; Ito, M.; Sato, K.; Okuda, K.; Sakakibara, T.; Okamoto, Y.; Jinno, H.

10.1101/2022.04.11.487970 — microbiology — Posted on 2022-04-12

2237 The SARS-CoV-2 receptor-binding domain facilitates neutrophil transepithelial migration and nanoparticle uptake in the mice airways

Bolkhovitina, E. L.; Vavilova, J. D.; Bogorodskiy, A. O.; Zagryadskaya, Y. A.; Okhrimenko, I. S.; Sapozhnikov, A. M.; Borshchevskiy, V. I.; Shevchenko, M. A.

10.1101/2022.04.12.488042 — immunology — Posted on 2022-04-12

2238 Broadly neutralizing antibodies target the coronavirus fusion peptide

Dacon, C.; Tucker, C.; Peng, L.; Lee, C.-C. D.; Lin, T.-H.; Yuan, M.; Cong, Y.; Wang, L.; Purser, L.; Williams, J. K.; Pyo, C.-W.; Kosik, I.; Hu, Z.; Zhao, M.; Mohan, D.; Cooper, A.; Peterson, M.; Skinner, J.; Dixit, S.; Kollins, E.; Huzella, L.; Perry, D.; Byrum, R.; Lembirik, S.; Zhang, Y.; Yang, E. S.; Chen, M.; Leung, K.; Weinberg, R. S.; Pegu, A.; Geraghty, D.; Davidson, E.; Douagi, I.; Moir, S.; Yewdell, J. W.; Schmaljohn, C.; Crompton, P. D.; Holbrook, M. R.; Nemazee, D.; Mascola, J. R.; Wilson, I. A.; Tan, J.

10.1101/2022.04.11.487879 — immunology — Posted on 2022-04-12

2239 Hierarchical Computational Modeling and Dynamic Network Analysis of Allosteric Regulation in the SARS-CoV-2 Spike Omicron Trimer Structures: Omicron Mutations Cooperate to Allosterically Control Balance of Protein Stability and Conformational Adaptability

Verkhivker, G. M.; Agajanian, S.; Kassab, R.; Krishnan, K.

10.1101/2022.04.11.487920 — biophysics — Posted on 2022-04-12

2240 How the replication and transcription complex functions in jumping transcription of SARS-CoV-2

Liang, J.; Shi, J.; Chen, S.; Duan, G.; Yang, F.; Zhi, C.; Li, X.; Ruan, J.; Mi, D.; Shan, G.

10.1101/2021.02.17.431652 — bioinformatics — Posted on 2022-04-12

2241 A high potent synthetic nanobody with broad-spectrum activity neutralizes SARS-Cov-2 virus and Omicron variant through a unique binding mode

Huang, H.; Li, S.; Tao, Y.; Xing, D.; Xiong, H.; Zhang, J.; Li, L.; Yang, X.; Jiang, D.; Luan, L.; Lin, Y.; Liu, X.; Zheng, Q.; Zhao, D.; Xia, N.; Liu, L.

10.1101/2022.04.11.487660 — biochemistry — Posted on 2022-04-12

2242 Strong and consistent associations of waterbird community composition with HPAI H5 occurrence in European wild birds

Huang, Z.; Yin, S.; Zhang, Y.; de Boer, F.; Mundkur, T.; Artois, J.; Velckers, F.; Tian, H.; Takekawa, J. Y.; Si, Y.; Han, G.-Z.; Zhang, H.; Chen, Y.; Chai, H.; Xu, C.

10.1101/2022.04.11.487853 — ecology — Posted on 2022-04-12

2243 An ACAT inhibitor regulates SARS-CoV-2 replication and antiviral T cell activity

Schmidt, N. M.; Wing, P. A.; Peters, R.; Brown, R.; Wang, H.; Swadling, L.; Newman, J.; Thakur, N.; Shionoya, K.; Morgan, S. B.; Hinks, T. S.; Watashi, K.; Bailey, D.; Hansen, S. B.; Maini, M. K.; McKeating, J. A.

10.1101/2022.04.12.487988 — immunology — Posted on 2022-04-12

2244 Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

Chen, M.; Pekosz, A.; Villano, J.; Shen, W.; Zhou, R.; Kulaga, H.; Li, Z.; Beck, S. E.; Witwer, K. W.; Mankowski, J.; Ramanathan, M.; Rowan, N.; Lane, A.

10.1101/2022.04.12.487379 — pathology — Posted on 2022-04-12

2245 Influence of circular RNA topology on microRNA stability

Fuchs Whightman, F.; Lukin, J.; Giusti, S.; Bragado, L.; Pozzi, B.; Gonzalez, P.; Fededa, J. P.; Refojo, D.; de la Mata, M.

10.1101/2022.04.11.487822 — molecular biology — Posted on 2022-04-12

2246 The ADAM17 sheddase complex regulator iTAP modulates inflammation, epithelial repair, and tumor growth

Adrain, C.; Badenes, M.; Burbridge, E.; Oikonomidi, I.; Amin, A.; de Carvalho, E.; Kosack, L.; Domingos, P. M.; Faisca, P.

10.1101/2022.04.11.487842 — molecular biology — Posted on 2022-04-12

2247 DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness

Carrier, A.; Desjobert, C.; Ponger, L.; Lamant, L.; Bustos, M.; Torres-Ferreira, J.; Henrique, R.; Jeronimo, C.; Lanfrancone, L.; Delmas, A.; Favre, G.; Delaunay, A.; Busato, F.; Hoon, D. S. B.; Tost, J.; Etievant, C.; Riond, J.; Arimondo, P. B.

10.1101/2022.04.11.487909 — cancer biology — Posted on 2022-04-12

2248 Multi-trait genomic prediction improves selection accuracy for enhancing seed mineral concentrations in pea (Pisum sativum L.)

Atanda, s. A.; Steffes, J.; Lan, Y.; Al Bari, M. A.; Kim, J.; Morales, M.; Johnson, J.; Saludares, R. A.; Worral, H.; Piche, L.; Ross, A.; Grusak, M. A.; Coyne, C. J.; McGee, R. J.; Rao, J.; Bandillo, N.

10.1101/2022.04.11.487944 — genetics — Posted on 2022-04-12

2249 Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host

Loghry, H. J.; Kwon, H.; Smith, R. C.; Sondjaja, N. A.; Minkler, S.; Young, S.; Wheeler, N. J.; Zamanian, M.; Bartholomay, L.; Kimber, M. J.

10.1101/2022.04.11.487926 — immunology — Posted on 2022-04-12

2250 A deep learning-based automated closed-loop optogenetic system for neuromodulation during seizures

Batabyal, T.; Brodovskaya, A.; Williamson, J.; Kapur, J.

10.1101/2022.04.11.487951 — neuroscience — Posted on 2022-04-12

2251 Causal contributions of the domain-general (Multiple Demand) and the language-selective brain networks to perceptual and semantic challenges in speech comprehension

MacGregor, L. J.; Gilbert, R. A.; Balewski, Z.; Mitchell, D. J.; Erzinclioglu, S. W.; Rodd, J. M.; Duncan, J.; Fedorenko, E.; Davis, M. H.

10.1101/2022.04.12.487989 — neuroscience — Posted on 2022-04-12

2252 A Causal Role of Human Laryngeal Motor Cortex in Speech Lexical Tone and Voicing Perception

Liang, B.; Li, Y.; Zhao, W.; Du, Y.

10.1101/2022.04.12.487725 — neuroscience — Posted on 2022-04-12

2253 Interneuronal network model of theta-nested fast oscillations predicts differential effects of heterogeneity, gap junctions and short term depression for hyperpolarizing versus shunting inhibition

Via, G.; Fernandez, F. R.; White, J. A.; Canavier, C. C.

10.1101/2022.04.11.487977 — neuroscience — Posted on 2022-04-12

2254 Typical hippocampal transcriptional response across estrous is dysregulated by Cnih3 gene deletion

Mulvey, B.; Frye, H. E.; Lintz, T.; Fass, S.; Tycksen, E.; Nelson, E. C.; Moron, J. A.; Dougherty, J.

10.1101/2022.04.11.487915 — neuroscience — Posted on 2022-04-12

2255 Sensory conflict disrupts circadian rhythms in the sea anemone Nematostella vectensis.

Berger, C. A.; Tarrant, A. M.

10.1101/2022.04.11.487933 — zoology — Posted on 2022-04-12

2256 Bayesian Parameter Estimation for Dynamical Models in Systems Biology

Linden, N. J.; Kramer, B.; Rangamani, P.

10.1101/2022.04.11.487931 — systems biology — Posted on 2022-04-12

2257 Thermophoresis of Molecules and Structures of different Sizes in Self-assembled Biomatrices

Liu, P.; Lin, W.; Abele, F.; Hanke, M.; Xin, Y.; Keller, A.; Zhang, Y.

10.1101/2022.04.11.487957 — biophysics — Posted on 2022-04-12

2258 Reducing peptide sequence bias in quantitative mass spectrometry data with machine learning

Dincer, A. B.; Lu, Y.; Schweppe, D.; Oh, S.; Noble, W. S.

10.1101/2022.04.11.487945 — bioinformatics — Posted on 2022-04-12

2259 Stair Recognition for Robotic Exoskeleton Control using Computer Vision and Deep Learning

Kurbis, A. G.; Laschowski, B.; Mihailidis, A.

10.1101/2022.04.11.487925 — bioengineering — Posted on 2022-04-12

2260 Beyond bold versus shy: Zebrafish exploratory behavior falls into several behavioral clusters and is influenced by strain and sex

Rajput, N.; Parikh, K.; Kenney, J. W.

10.1101/2022.04.11.487928 — animal behavior and cognition — Posted on 2022-04-12

2261 Reanalysis shows the extreme decline effect does not exist in fish ocean acidification studies

Munday, P. L.

10.1101/2022.04.11.487807 — animal behavior and cognition — Posted on 2022-04-12

2262 Accurate Genome-Wide Phasing from IBD Data

Noto, K.; Ruiz, L.

10.1101/2022.04.11.487932 — genetics — Posted on 2022-04-12

2263 On the interaction between Janzen-Connell effects and habitat partitioning in spatially structured environments

Smith, D. J. B.

10.1101/2022.04.11.487940 — ecology — Posted on 2022-04-12

2264 Differences in the genetic structure between and within two landlocked Ayu groups with different migration patterns in Lake Biwa revealed by environmental DNA analysis

Tsuji, S.; Shibata, N.; Sawada, H.; Watanabe, K.

10.1101/2022.04.11.487953 — ecology — Posted on 2022-04-12

2265 Disrupting ACE2 Dimerization Mitigates the Infection by SARS-COV-2

Zhu, J.; Su, Y.; Tang, Y.

10.1101/2022.04.09.487739 — molecular biology — Posted on 2022-04-12

2266 Transient Oxygen Exposure Causes Profound and Lasting Changes to a Benzene-Degrading Methanogenic Community

Guo, S.; Toth, C. R. A.; Luo, F.; Chen, X. C.; Xiao, X. J.; Edwards, E. A.

10.1101/2022.04.11.487956 — microbiology — Posted on 2022-04-12

2267 A discovery pipeline for identification and in vivo validation of drugs that alter T cell/ dendritic cell interaction

Scales, H. E.; Keijzer, C.; Evertsson, E.; Garside, P.; Delaney, S.; Brewer, J. M.

10.1101/2022.04.11.487526 — immunology — Posted on 2022-04-12

2268 An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

Kragness, S.; Clark, Z.; Mullin, A.; Guidry, J.; Earls, L. R.

10.1101/2022.01.26.477857 — neuroscience — Posted on 2022-04-12

2269 Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality

Kim, B.; Haney, S.; Milan, A. P.; Joshi, S.; Aldworth, Z.; Kim, A. T.; Rulkov, N.; Bazhenov, M.; Stopfer, M. A.

10.1101/2022.04.11.487908 — neuroscience — Posted on 2022-04-12

2270 Electrophysiological normative responses to emotional, neutral, and cigarette-related images.

Versace, F.; Sambuco, N.; Deweese, M. M.; Cinciripini, P. M.

10.1101/2022.04.11.487896 — neuroscience — Posted on 2022-04-12

2271 Sex-specific differences in rotarod performance and type 1 cannabinoid receptor levels in a rat model of traumatic brain injury treated with {triangleup}9-tetrahydrocannabinol

Black, T.; Zagzoog, A.; Roebuck, A. J.; Greba, Q.; Neary, J. P.; Howland, J. G.; Laprairie, R. B.

10.1101/2022.04.11.487790 — neuroscience — Posted on 2022-04-12

2272 Evidence for shared resources in visuospatial attention: Endogenous attention misleads the decoding of exogenous attention in alpha rhythms

Landry, M.; da Silva Castanheira, J.; Baillet, S.; Sackur, J.; Raz, A.

10.1101/2022.04.11.487868 — neuroscience — Posted on 2022-04-12

2273 The Temporal Dynamics of Willed Attention in Vision

Nadra, J. G.; Bengson, J. J.; Morales, A. B.; Mangun, G. R.

10.1101/2022.04.11.487895 — neuroscience — Posted on 2022-04-12

2274 Metabolite profiles across populations of Palmer amaranth (Amaranthus palmeri) highlight the specificity and inducibility of phytochemical response to glyphosate stress.

Sandhu, P. K.; Leonard, E.; Nandula, V.; Tharayil, N.

10.1101/2022.04.11.486891 — plant biology — Posted on 2022-04-12

2275 Pharmacological Interrogation of the C. elegans Pharyngeal Cuticle Reveals Small Molecule Amyloid Disruptors

Kamal, M.; Knox, J.; Han, D.; Burns, A.; Nguyen, K. C.; Hall, D. H.; Roy, P. J.

10.1101/2022.04.11.487937 — pharmacology and toxicology — Posted on 2022-04-12

2276 Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing

Truong, D. D.; Lamhamedi-Cherradi, S.-E.; Porter, R. W.; Krishnan, S.; Swaminathan, J.; Gibson, A.; Lazar, A. J.; Livingston, J. A.; Gopalakrishnan, V.; Gordon, N.; Daw, N. C.; Gorlick, R.; Ludwig, J. A.

10.1101/2022.01.21.476982 — cancer biology — Posted on 2022-04-12

2277 Long-range morphogen gradient formation by cell-to-cell signal propagation

Dickmann, J. E. M.; Rink, J. C.; Jülicher, F.

10.1101/2022.04.11.487794 — biophysics — Posted on 2022-04-12

2278 Super-Resolution NMR Spectroscopy using the Intersection of Non-Redundant Information on Resonance Groups

Lorieau, J. L.; Malooley, A.; Banerjee, I.

10.1101/2022.04.11.487656 — biophysics — Posted on 2022-04-12

2279 Multimodal single cell data integration challenge: results and lessons learned

Lance, C.; Luecken, M. D.; Burkhardt, D. B.; Cannoodt, R.; Rautenstrauch, P.; Laddach, A. C.; Ubingazhibov, A.; Cao, Z.-J.; Deng, K.; Khan, S.; Liu, Q.; Russkikh, N.; Ryazantsev, G.; Ohler, U.; NeurIPS 2021 Multimodal data integration competition participants, ; Pisco, A. O.; Bloom, J. M.; Krishnaswamy, S.; Theis, F. J.

10.1101/2022.04.11.487796 — bioinformatics — Posted on 2022-04-12

2280 The snoGloBe interaction predictor reveals a broad spectrum of C/D snoRNA RNA targets

Deschamps-Francoeur, G.; Couture, S.; Abou Elela, S.; Scott, M. S.

10.1101/2021.09.14.460265 — bioinformatics — Posted on 2022-04-12

2281 Analysis of community connectivity in spatial transcriptomics data

Allen, C.; Jung, K. J.; Chang, Y.; Ma, Q.; Chung, D.

10.1101/2022.04.11.487907 — bioinformatics — Posted on 2022-04-12

2282 METACLUSTERplus - an R package for probabilistic inference and visualization of context-specific transcriptional regulation of biosynthetic gene clusters

Banf, M.

10.1101/2022.04.11.487835 — bioinformatics — Posted on 2022-04-12

2283 KMCP: accurate metagenomic profiling of both prokaryotic and viral populations by pseudo-mapping

Shen, W.; Xiang, H.; Huang, T.; Tang, H.; Peng, M.; Cai, D.; Hu, P.; Ren, H.

10.1101/2022.03.07.482835 — bioinformatics — Posted on 2022-04-12

2284 Intradiscal Inflammatory Stimulation Induces Spinal Pain Behavior and Intervertebral Disc Degeneration In Vivo

Lisiewski, L. E.; Jacobsen, H. E.; Viola, D. C.; Kenawy, H. M.; Kiridly, D. N.; Chahine, N. O.

10.1101/2022.04.11.487751 — bioengineering — Posted on 2022-04-12

2285 Extended Brain Sources Estimation via Unrolled Optimization Neural Network

Jiao, M.; Liu, F.

10.1101/2022.04.11.487935 — bioengineering — Posted on 2022-04-12

2286 scTAM-seq enables targeted high-confidence analysis of DNA methylation in single cells

Bianchi, A.; Scherer, M.; Zaurin, R.; Quililan, K.; Velten, L.; Beekman, R.

10.1101/2022.04.11.487648 — genomics — Posted on 2022-04-12

2287 The synaptonemal complex controls cis- versus trans-interference in coarsening-based meiotic crossover patterning

Fozard, J. A.; Morgan, C.; Howard, M.

10.1101/2022.04.11.487855 — genetics — Posted on 2022-04-12

2288 The conservation of human functional variants and their effects across mammals

Zhao, R.; Talenti, A.; Fang, L.; Liu, S.; Liu, G.; Chue Hong, N. P.; Tenesa, A.; Hassan, M. A.; Prendergast, J.

10.1101/2022.04.11.487854 — genetics — Posted on 2022-04-12

2289 Sexual selection for males with beneficial mutations

Roberts, G.; Petrie, M.

10.1101/2021.05.25.445661 — evolutionary biology — Posted on 2022-04-12

2290 The influence of biotic and abiotic drivers on arthropod co-occurrence network topology in native forest remnants in the Azores

Pozsgai, G.; Cardoso, P.; Rigal, F.; Boieiro, M. R. C.; Gabriel, R.; Brito de Azevedo, E.; Borges, P. A. V.

10.1101/2022.04.11.487852 — ecology — Posted on 2022-04-12

2291 Wake respirometry may quantify stress and energetics of free-living animals

Rose, K. A.; Wilson, R. P.; Ramenda, C.; Robotka, H.; Wikelski, M. P.; Shepard, E.

10.1101/2022.04.11.487318 — ecology — Posted on 2022-04-12

2292 Expansion of Ventral Foregut Primes the Enhancer Landscape for Organ Specific Differentiation

Wong, Y. F.; Kumar, Y.; Proks, M.; Herrera, J. A. R.; Rothova, M. M.; Monteiro, R. S.; Pozzi, S.; Jennings, R. E.; Hanley, N. A.; Bickmore, W. A.; Brickman, J. M.

10.1101/2022.04.11.487673 — developmental biology — Posted on 2022-04-12

2293 The specific roles of renal macrophages in monitoring and clearing off intratubular particles

He, J.; Cao, Y.; Zhu, Q.; Wang, X.; Cheng, G.; Wang, Q.; Han, F.; Shi, P.; Shen, X. Z.

10.1101/2022.04.11.487834 — immunology — Posted on 2022-04-12

2294 Hypervoxels: A Multidimensional Framework For The Representation And Analysis Of Neuroimaging Data

Luque Laguna, P. A.; Beyh, A.; De Santiago Requejo, F.; Stones, R.; Jones, D. K.; Goldstein, L. H.; Catani, M.; Williams, S. C. R.; Dell'Acqua, F.

10.1101/2022.04.11.485553 — neuroscience — Posted on 2022-04-12

2295 Two-photon microscopy in vivo reveals brain vessel type-specific loss of glycocalyx caused by apoM/S1P signaling impairment.

Kucharz, K.; Mathiesen Janiurek, M.; Christoffersen, C.; Lauritzen, M.

10.1101/2022.04.11.487803 — neuroscience — Posted on 2022-04-12

2296 Data-driven large-scale genomic analysis reveals an intricate phylogenetic and functional landscape in J-domain proteins

Malinverni, D.; Zamuner, S.; Barducci, A.; Nillegoda, N. B.; De Los Rios, P.

10.1101/2022.02.28.482344 — bioinformatics — Posted on 2022-04-12

2297 Evolution of class-structured populations in fluctuating environments

Lion, S.; Gandon, S.

10.1101/2021.03.12.435065 — evolutionary biology — Posted on 2022-04-12

2298 Beetle bioluminescence outshines aerial predators

Powell, G. S.; Saxton, N. A.; Pacheco, Y.; Stanger-Hall, K. F.; Martin, G. J.; Kusy, D.; Da Silveira, L. F. L.; Bocak, L.; Branham, M. A.; Bybee, S. M.

10.1101/2021.11.22.469605 — evolutionary biology — Posted on 2022-04-12

2299 Positive fitness effects help explain the broad range of Wolbachia prevalences in natural populations

Karisto, P.; Duplouy, A.; de Vries, C.; Kokko, H.

10.1101/2022.04.11.487824 — ecology — Posted on 2022-04-12

2300 Effects of adaptive harvesting on fishing down processes and resilience changes in predator-prey systems

Tromeur, E.; Loeuille, N.

10.1101/290460 — ecology — Posted on 2022-04-12

2301 Plant protection habits among Hungarian farmers and garden owners and their implications for pollinator protection

Varga-Szilay, Z.; Pozsgai, G.

10.1101/2022.04.07.487523 — ecology — Posted on 2022-04-12

2302 Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality

Budhraja, A.; Basu, A.; Gheware, A.; Abhilash, D.; Rajagopala, S.; Pakala, S.; Sumit, M.; Ray, A.; Arulselvi, S.; Mathur, P.; Nambirajan, A.; Kumar, S.; Gupa, R.; Wig, N.; Trikha, A.; Guleria, R.; Sarkar, C.; Gupta, I.; Jain, D.

10.1101/2021.11.08.467705 — molecular biology — Posted on 2022-04-12

2303 Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response.

Pais, T. F.; Ali, H.; Silva, J. M. d.; Duarte, N.; Neres, R.; Chhatbar, C.; Acurcio, R. C.; Guedes, R. C.; Moraes, M. C. S.; Costa-Silva, B.; Ulrich, K.; Penha-Goncalves, C.

10.1101/2022.02.14.480268 — immunology — Posted on 2022-04-12

2304 Prediction of infectivity of SARS-CoV2: Mathematical model with analysis of docking simulation for spike proteins and angiotensin-converting enzyme 2

Takaoka, Y.; Sugano, A.; Morinaga, Y.; Ohta, M.; Miura, K.; Kataguchi, H.; Kumaoka, M.; Kimura, S.; Maniwa, Y.

10.1101/2022.03.30.486373 — bioinformatics — Posted on 2022-04-12

2305 Early epigenetic influence on EGR1, KLF2 and KLF4 transcriptional network associates with alteration of HSCs quiescence

Pelletier, A.; Carrier, A.; Zhao, Y.; Canouil, M.; Derhourhi, M.; Durand, E.; Berberian-Ferrato, L.; Greally, J.; Hughes, F.; Froguel, P.; Bonnefond, A.; Delahaye, F.

10.1101/2021.10.22.465419 — genomics — Posted on 2022-04-12

2306 Bespoke data augmentation and network construction enable developmental morphological classification on limited microscopy datasets

Groves, I.; Holmshaw, J.; Furley, D.; Towers, M.; Evans, B. D.; Placzek, M.; Fletcher, A. G.

10.1101/2022.02.18.480991 — developmental biology — Posted on 2022-04-12

2307 The functional role of episodic memory in spatial learning

Zeng, X.; Wiskott, L.; Cheng, S.

10.1101/2021.11.24.469830 — neuroscience — Posted on 2022-04-12

2308 Gradients in cellular metabolism regulate development of tonotopy along the chick cochlea.

Blacker, T. S.; O'Sullivan, J. D.; Yianni, V.; Ahmed, M.; Mann, Z. F.

10.1101/2022.04.11.487851 — developmental biology — Posted on 2022-04-12

2309 Every individual makes a difference: A trinity derived from linking individual brain morphometry, connectivity and mentalising ability

Li, Z.; Dong, Q.; Hu, B.; Wu, H.

10.1101/2022.04.11.487870 — neuroscience — Posted on 2022-04-12

2310 NetTIME: improving multitask transcription factor binding site prediction with base-pair resolution

Yi, R.; Cho, K.; Bonneau, R.

10.1101/2021.05.29.446316 — systems biology — Posted on 2022-04-12

2311 DOT1L activity affects cell lineage progression in the developing brain by controlling metabolic programs

Appiah, B.; Fullio, C.; Haffner, C.; Zeis, P.; Treppner, M.; Bovio, P. P.; Cheffer, A.; Bertani, I.; Binder, H.; Gruen, D.; Kalebic, N.; Taverna, E.; Vogel, T.

10.1101/2022.04.08.487591 — developmental biology — Posted on 2022-04-12

2312 Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation

Wanigasuriya, I.; Kinkel, S. A.; Beck, T.; Roper, E. A.; Breslin, K.; Lee, H. J.; Keniry, A.; Ritchie, M. E.; Blewitt, M. E.; Gouil, Q.

10.1101/2021.10.21.465360 — genomics — Posted on 2022-04-12

2313 Detection and molecular characterization of a phytoplasma associated with Cucumber (Cucumis sativus) and its first report from India

Muttappagol, M.; H. D., V. K.; Hiremath, S.; M., N.; C. R., J. B.; K. S., S.; V, V.; Reddy, C. N. L.

10.1101/2022.04.04.486938 — molecular biology — Posted on 2022-04-11

2314 Spatially resolved gene regulatory and disease vulnerability map of the adult Macaque cortex

Lei, Y.; Cheng, M.; Li, Z.; Zhuang, Z.; Wu, L.; Sun, Y.; Han, L.; Huang, Z.; Wang, Y.; Wang, Z.; Xu, L.; Yuan, Y.; Liu, S.; Pan, T.; Xie, J.; Liu, C.; Volpe, G.; Ward, C.; Lai, Y.; Xu, J.; Wang, M.; Yu, H.; Sun, H.; Yu, Q.; Wu, L.; Wang, C.; Wong, C. W.; Liu, W.; Xu, L.; Wei, J.; Chen, D.; Shang, Z.; Li, G.; Ma, K.; Cheng, L.; Ling, F.; Tan, T.; Chen, K.; Tasic, B.; Dean, M.; Ji, W.; Yang, H.; Gu, Y.; Esteban, M. A.; Li, Y.; Chen, A.; Niu, Y.; Zeng, H.; Hou, Y.; Liu, L.; Liu, S.; Xu, X.

10.1101/2020.05.14.087601 — neuroscience — Posted on 2022-04-11

2315 Screening of hydrocarbon-stapled peptides for inhibition of calcium-triggered exocytosis

Lai, Y.; Tuvim, M.; Leitz, J.; Peters, J. J.; Pfuetzner, R.; Esquivies, L.; Zhou, Q.; Czako, B.; Cross, J.; Jones, P.; Dickey, B.; Brunger, A. T.

10.1101/2022.03.21.484632 — pharmacology and toxicology — Posted on 2022-04-11

2316 Trascriptome meta-analysis of microalga Dunaliella tertiolecta under stress condition

Panahi, B.; Farhadian, M.; Mohammadi, S. A.; hejazi, M. A.

10.1101/2022.04.11.487921 — genomics — Posted on 2022-04-11

2317 Epistasis between synonymous and nonsynonymous mutations in Dictyostelium discoideum ammonium transporter amtA drives functional complementation in Saccharomyces cerevisiae.

Densi, A.; Iyer, R. S.; Bhat, P. J.

10.1101/2022.04.05.486919 — genetics — Posted on 2022-04-11

2318 Low-cost genomics enable high-throughput isolate screening and strain-level microbiome profiling

Sanders, J. G.; Yan, W.; Moeller, A. H.

10.1101/2022.04.11.487950 — microbiology — Posted on 2022-04-11

2319 INRI-seq enables global cell-free analysis of translation initiation and off-target effects of antisense inhibitors

Hör, J.; Jung, J.; Đurica-Mitic, S.; Barquist, L.; Vogel, J.

10.1101/2022.04.11.487859 — microbiology — Posted on 2022-04-11

2320 A population of gray matter oligodendrocytes directly associates with the vasculature

Palhol, J. S. C.; Balia, M.; Teran, F. S.-R.; Labarchede, M.; Gontier, E.; Battefeld, A.

10.1101/2022.04.11.487873 — neuroscience — Posted on 2022-04-11

2321 Elp1 is required for development of visceral sensory peripheral and central circuitry

Lefcort, F.; Chaverra, M.; Tolman, Z.; George, L.

10.1101/2022.04.11.487663 — neuroscience — Posted on 2022-04-11

2322 Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in the liver

Kim, D.; Kim, B.; Brocker, C. N.; Karri, K.; Waxman, D. J.; Gonzalez, F. J.

10.1101/2022.04.11.487900 — physiology — Posted on 2022-04-11

2323 A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening

Singh, M. K.; Yadav, R.; Bhaskar, A. K.; Sengupta, S.; Sachidanandan, C.

10.1101/2022.04.11.487858 — pharmacology and toxicology — Posted on 2022-04-11

2324 Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of malignant pleural mesotheliomas to CDK4/6 inhibition

Paternot, S.; Raspe, E.; Meiller, C.; Tarabichi, M.; Assie, J.-B.; Libert, F.; Remmelink, M.; Bisteau, X.; Pauwels, P.; Blum, Y.; Le Stang, N.; Tabone-Eglinger, S.; Galateau-Salle, F.; Blanquart, C.; Van Meerbeeck, J. P.; Berghmans, T.; Jean, D.; Roger, P. P.

10.1101/2022.04.11.487857 — cancer biology — Posted on 2022-04-11

2325 Fatty sweet symphony: Decoding distinct ganglioside patterns of native and differentiated mesenchymal stem cells by a novel glycolipidomics profiling strategy

Hohenwallner, K.; Troppmair, N.; Panzenboeck, L.; Kasper, C.; El Abiead, Y.; Koellensperger, G.; Lamp, L. M.; Hartler, J.; Egger, D.; Rampler, E.

10.1101/2022.04.11.487866 — biochemistry — Posted on 2022-04-11

2326 Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents

Sanderson, H.; Gray, K. L.; Manuele, A.; Maguire, F.; Khan, A.; Liu, C.; Navanekere Rudrappa, C.; Nash, J. H. E.; Robertson, J.; Bessonov, K.; Oloni, M.; Alcock, B. P.; Raphenya, A. R.; McAllister, T. A.; Peacock, S. J.; Raven, K. E.; Gouliouris, T.; McArthur, A. G.; Brinkman, F. S.; Fink, R. C.; Zaheer, R.; Beiko, R. G.

10.1101/2022.04.11.487771 — genomics — Posted on 2022-04-11

2327 Critical Role of Insertion Preference for Invasion Trajectory of Transposons

Munasinghe, M.; Springer, N. M.; Brandvain, Y. J.

10.1101/2022.04.11.487916 — evolutionary biology — Posted on 2022-04-11

2328 Phylogenetic Network Dissimilarity Measures That Take Branch Lengths Into Account

Yakici, B. A.; Ogilvie, H. A.; Nakhleh, L.

10.1101/2022.02.22.481483 — evolutionary biology — Posted on 2022-04-11

2329 Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist

Norris, E. G.; Pan, X. S.; Hocking, D. C.

10.1101/2022.04.11.487882 — cell biology — Posted on 2022-04-11

2330 Autophagy Increases Occludin Levels to Enhance Intestinal Paracellular Tight Junction Barrier.

Saha, K.; Ganapathy, A. S.; Wang, A.; Morris, N. M.; Suchanec, E.; Yochum, G. S.; Koltun, W.; Ding, W.; Nighot, M.; Ma, T.; Nighot, P.

10.1101/2022.04.11.487876 — cell biology — Posted on 2022-04-11

2331 A synthetic ancestral Kinesin-13 depolymerises microtubules faster than any natural depolymerising kinesin

Belsham, H. R.; Alghamdi, H. M.; Dave, N.; Rathbone, A. J.; Wickstead, B.; Friel, C. T.

10.1101/2022.04.11.487848 — molecular biology — Posted on 2022-04-11

2332 Disrupting ACE2 Dimerization Mitigates the Infection by SARS-COV-2

Zhu, J.; Su, Y.; Tang, Y.

10.1101/2022.04.09.487739 — molecular biology — Posted on 2022-04-11

2333 UBC9 and EME1 sumoylation foster ribosomal DNA damage repair in CPT response

Nagamalleswari, E.; Bakshi, K.; Breucker, J.; Gschweitl, M.; Gonzalez-Prieto, R.; Eisenhardt, N.; Fatouros, C.; Chaugule, V. K.; Vertegaal, A.; Pichler, A.

10.1101/2022.04.11.487628 — molecular biology — Posted on 2022-04-11

2334 Key mutations on spike protein altering ACE2 receptor utilization and potentially expanding host range of emerging SARS-CoV-2 variants

Wang, Q.; Ye, S.-B.; Zhou, Z.-J.; Li, J.-Y.; Lv, J.-Z.; Hu, B.; Yuan, S.; Qiu, Y.; Ge, X.-Y.

10.1101/2022.04.11.487828 — microbiology — Posted on 2022-04-11

2335 SARS-ANI: A Global Open Access Dataset of Reported SARS-CoV-2 Events in Animals

Nerpel, A.; Yang, L.; Sorger, J.; Kaesbohrer, A.; Walzer, C.; Desvars-Larrive, A.

10.1101/2022.04.11.487836 — microbiology — Posted on 2022-04-11

2336 In vivo low-intensity magnetic pulses durably alter neocortical neuron excitability and spontaneous activity.

Boyer, M.; Baudin, P.; Stengel, C.; Valero-Cabre, A.; Lohof, A. M.; Charpier, S.; Sherrard, R. M.; Mahon, S.

10.1101/2022.03.18.484911 — neuroscience — Posted on 2022-04-11

2337 Rational design by structural biology of industrializable, long-acting antihyperglycemic GLP-1 receptor agonists

Sun, L.; Zheng, Z.-M.; Shao, C.-S.; Li, M.-W.; Wang, L.; Wang, H.; Zhao, G.-H.; Wang, P.

10.1101/2022.04.11.487850 — bioengineering — Posted on 2022-04-11

2338 An intrinsically disordered transcription activation domain alters the DNA binding affinity and specificity of NFκB p50/RelA

Baughman, H. E. R.; Narang, D.; Chen, W.; Suarez, A. C. V.; Lee, J.; Bachochin, M. J.; Gunther, T. R.; Wolynes, P. G.; Komives, E. A.

10.1101/2022.04.11.487922 — biochemistry — Posted on 2022-04-11

2339 Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions

Zhao, Y.; Coelho, C.; Hughes, A. L.; Lazar-Stefanita, L.; Yang, S.; Brooks, A. N.; Walker, R. S. K.; Zhang, W.; Lauer, S.; Hernandez, C.; Mitchell, L. A.; Agmon, N.; Shen, Y.; Sall, J.; Fanfani, V.; Jalan, A.; Rivera, J.; Liang, F.-X.; Stracquadanio, G.; Steinmetz, L. M.; Cai, Y. P.; Boeke, J. D.

10.1101/2022.04.11.486913 — genomics — Posted on 2022-04-11

2340 Phylotranscriptomics Reveals the Reticulate Evolutionary History of a Widespread Diatom Species Complex

Ciftci, O.; Alverson, A. J.; van Bodegom, P.; Roberts, W. R.; Mertens, A.; Van de Vijver, B.; Trobajo, R.; Mann, D. G.; Pirovano, W.; van Eijk, I.; Gravendeel, B.

10.1101/2022.04.11.487918 — genomics — Posted on 2022-04-11

2341 The Requirement of Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in Mouse Ovarian Development and Fertility

Woodman, M. F.; Ozcan, M. C. H.; Gura, M. A.; De La Cruz, P.; Gadson, A. K.; Grive, K. J.

10.1101/2022.02.08.479454 — developmental biology — Posted on 2022-04-11

2342 Gradients in cellular metabolism regulate development of tonotopy along the chick cochlea.

Blacker, T. S.; O'Sullivan, J. D.; Yianni, V.; Ahmed, M.; Mann, Z. F.

10.1101/2022.04.11.487851 — developmental biology — Posted on 2022-04-11

2343 Reduced affinity of calcium sensing-receptor heterodimers and reduced mutant homodimer trafficking combine to impair function in a mouse model of Familial Hypocalciuric Hypercalcemia Type 1

Wang, X.; Lundblad, J.; Smith, S. M.

10.1101/2022.04.11.487493 — cell biology — Posted on 2022-04-11

2344 A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target

Davaapil, H.; McNamara, M.; Granata, A.; Macrae, R. G. C.; Hirano, M.; Fitzek, M.; Aragon-Martin, J. A.; Child, A.; Smith, D. M.; Sinha, S.

10.1101/2022.04.11.487841 — cell biology — Posted on 2022-04-11

2345 Separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis

Nilsson, J.; Wang, L.; Kruse, T.; Lopez-Mendez, B.; Zhang, Y.; Song, C.; Zhu, L.; Li, B.; Fang, J.; Lu, z.; Zhang, G.

10.1101/2022.04.11.487869 — cell biology — Posted on 2022-04-11

2346 An adaptive filtering framework for non-specific and inefficient reactions in multiplex digital PCR based on sigmoidal trends

Miglietta, L.; Xu, K.; Chhaya, P. M.; Kreitmann, L.; Hill-Cawthorne, K.; Bolt, F.; Holmes, A. H.; Georgiou, P.; Rodriguez-Manzano, J.

10.1101/2022.04.11.487847 — molecular biology — Posted on 2022-04-11

2347 Multi-level monitoring of EME1-MUS81 in CPT induced nucleolar rDNA repair

Bakshi, K.; Nagamalleswari, E.; Breuker, J.; Eisenhardt, N.; Tiwari, R.; Gonzalez-Prieto, R.; Fatouros, C.; Chaugule, V.; Lee, H.; Ilic, D.; Trulsson, F.; Mittler, G.; Vertegaal, A. C. O.; Pichler, A.

10.1101/2022.04.11.487769 — molecular biology — Posted on 2022-04-11

2348 Quantitation of FGFR3 signaling via GRB2 recruitment on micropatterned surfaces

Hartl, I.; Brumovska, V.; Striedner, Y.; Yasari, A.; Schuetz, G. J.; Sevcsik, E.; Tiemann-Boege, I.

10.1101/2022.04.11.487861 — molecular biology — Posted on 2022-04-11

2349 An electro-optical bead-nanochip technology for the ultrasensitive and multi-dimensional detection of small extracellular vesicles and their markers

Dias, T.; Figueiras, R.; Vagueiro, S.; Domingues, R.; Hung, Y.-H.; Persia, E.; Arsene, P.

10.1101/2022.04.11.487936 — molecular biology — Posted on 2022-04-11

2350 Toxoplasma scavenges mammalian host organelles through usurpation of host ESCRT-III and Vps4

Coppens, I.; Romano, J. D.; Mayoral, J. A.; Guevara, R.; Rivera-Cuevas, Y.; Carruthers, V. B.; Weiss, L. M.

10.1101/2022.04.11.487923 — microbiology — Posted on 2022-04-11

2351 RNA-protein interactome at the Hepatitis E virus internal ribosome entry site

Kumar, S.; Verma, R.; Saha, S.; Agrahari, A.; Shukla, S.; Anurag, ; Maiti, T. K.; Asthana, S.; Ranjith-Kumar, C. T.; Surjit, M.

10.1101/2022.04.11.487827 — microbiology — Posted on 2022-04-11

2352 Peptidoglycan maturation controls spatiotemporal organisation of outer membrane proteins in Escherichia coli

Mamou, G.; Corona, F.; Cohen-Khait, R.; Sun, D.; Sridhar, P.; Pazos, M.; Knowles, T. J.; Kleanthous, C.; Vollmer, W.

10.1101/2022.04.11.487844 — microbiology — Posted on 2022-04-11

2353 Genotypic and phenotypic diversity of the multidrug-resistant Mycobacterium tuberculosis strains from eastern India

Ghosh, A.; Bal, H.; Biswas, V. K.; Das, D.; Pati, S.; Raghav, S. K.

10.1101/2022.04.11.487831 — microbiology — Posted on 2022-04-11

2354 Candidate genes associated with neurological manifestations of COVID-19: Meta-analysis using multiple computational approaches

Hazra, S.; Ghosh Chaudhuri, A.; Tiwary, B. K.; Chakrabarti, N.

10.1101/2022.04.10.487761 — systems biology — Posted on 2022-04-11

2355 3D Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast

Lewis, R.; Baskaran, H.; Green, J.; Tashev, S.; Palaiologou, E.; Lofthouse, E. M.; Cleal, J. K.; Page, A.; Chatelet, D.; Goggin, P.; Sengers, B. G.

10.1101/2022.01.26.477815 — physiology — Posted on 2022-04-11

2356 Differential Histone-DNA Interactions Dictate Nucleosome Recognition of the Pioneer Transcription Factor Sox

Ozden, B.; Boopathi, R.; Barlas, A. B.; Lone, I. N.; Bednar, J.; Petosa, C.; Kale, S.; Hamiche, A.; Angelov, D.; Dimitrov, S.; Karaca, E.

10.1101/2021.12.07.471700 — biophysics — Posted on 2022-04-11

2357 Subtyping of major SARS-CoV-2 variants reveals different transmission dynamics

Yang, H.-C.; Wang, J.-H.; Yang, C.-T.; Lin, Y.-C.; Hsieh, H.-N.; Chen, P.-W.; Liao, H.-C.; Chen, C.-h.; Liao, J. C.

10.1101/2022.04.10.486823 — bioinformatics — Posted on 2022-04-11

2358 Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-associated Excitable Cells

Borja, G. B.; Zhang, H.; Harwood, B. N.; Jacques, J.; Grooms, J.; Chantre, R.; Zhang, D.; Barnett, A.; Werley, C. A.; Lu, Y.; Nagle, S.; McManus, O. B.; Dempsey, G. T.

10.1101/2022.04.11.487888 — bioengineering — Posted on 2022-04-11

2359 Inverted genomic regions between reference genome builds in humans impact imputation accuracy and decrease the power of association testing

Sheng, X.; Xia, L.; Conti, D. V.; Haiman, C. A.; Kachuri, L.; Chiang, C. W. K.

10.1101/2022.02.19.481174 — genomics — Posted on 2022-04-11

2360 Independent acquisition of short insertions at the RIR1 site in the spike N-terminal domain of the SARS-CoV-2 BA.2 lineage

Greco, S.; Gerdol, M.

10.1101/2022.04.11.487924 — genomics — Posted on 2022-04-11

2361 Comprehensive multiomic profiling of somatic mutations in malformations of cortical development

Chung, C.; Yang, X.; Bae, T.; Vong, K. I.; Mittal, S.; Donkels, C.; Phillips, W.; Marsh, A. P. L.; Breuss, M. W.; Ball, L. L.; Garcia, C. A. B.; George, R. D.; Gu, J.; Xu, M.; Barrows, C.; James, K. N.; Stanley, V.; Nidhiry, A.; Khoury, S.; Howe, G.; Xu, X.; Copeland, B.; Antaki, D.; Wang, Y.; Kim, S. H.; Kang, H.-C.; Schulze-Bonhage, A.; Haas, C. A.; Urbach, H.; Prinz, M.; Sattar, S.; Nespeca, M.; Gonda, D. D.; Imai, K.; Takahashi, Y.; Chen, R.; Tsai, J.-W.; Conti, V.; Guerrini, R.; Devinsky, O.; Silva, W. A.; Machado, H. R.; Mathern, G. W.; Abyzov, A.; Baldassari, S.; Baulac, S.; Focal Corti

10.1101/2022.04.07.487401 — genetics — Posted on 2022-04-11

2362 Newfoundland and Labrador: A mosaic founder population of an Irish and British diaspora from 300 years ago.

Gilbert, E. H.; Zurel, H.; MacMillan, M. E.; Demirez, S.; Mirhendi, S.; Merrigan, M.; O'Reilly, S.; Molloy, A. M.; Brody, L. C.; Bodmer, W. F.; Leach, R. A.; Mugford, G.; Randhawa, R.; Stephens, J. C.; Symington, A. L.; Cavalleri, G. L.; Phillips, M. S.

10.1101/2022.04.01.486593 — genetics — Posted on 2022-04-11

2363 Hybridization alters the shape of the genotypic fitness landscape, increasing access to novel fitness peaks during adaptive radiation

Patton, A. H.; Richards, E.; Gould, K. J.; Buie, L. K.; Martin, C. H.

10.1101/2021.07.01.450666 — evolutionary biology — Posted on 2022-04-11

2364 Modulation of RNA polymerase processivity affects double-strand break repair in the presence of a DNA end-binding protein

Sivaramakrishnan, P.; Bradley, C. C.; Artsimovitch, I.; Hagstrom, K. M.; Ramirez, L. D.; Wen, A. X.; Cooke, M. B.; Shaulsky, M.; Herman, C.; Halliday, J. A.

10.1101/2022.02.08.479637 — molecular biology — Posted on 2022-04-11

2365 Correlation between speed and turning naturally arises for sparsely sampled cell movements

Ganusov, V. V.; Zenkov, V. S.; Majumder, B.

10.1101/2020.12.30.424897 — immunology — Posted on 2022-04-11

2366 Encoding and decoding analysis of music perception using intracranial EEG

Bellier, L.; Llorens, A.; Marciano, D.; Schalk, G.; Brunner, P.; Knight, R. T.; Pasley, B. N.

10.1101/2022.01.27.478085 — neuroscience — Posted on 2022-04-11

2367 EXTERNAL CONTROL OF CANCER CELLULAR DYNAMICS USING ADAPTIVE MODEL PREDICTIVE CONTROL

Smart, B.; De Cesare, I.; Renson, L.; Marucci, L.

10.1101/2022.03.14.484268 — systems biology — Posted on 2022-04-11

2368 Application of Parallel Reaction Monitoring in 15N labeled Samples for Quantification

Reyes, A. V.; Shrestha, R.; Baker, P. R.; Chalkley, R. J.; Xu, S.-L.

10.1101/2021.12.01.470846 — plant biology — Posted on 2022-04-11

2369 Suppression of chromosome instability limits acquired drug resistance

Crowley, E. A.; Hermance, N. M.; Herlihy, C. P.; Manning, A. L.

10.1101/2020.07.10.197350 — cancer biology — Posted on 2022-04-11

2370 Neuromuscular embodiment of feedback control elements in Drosophila flight

Whitehead, S. C.; Leone, S.; Lindsay, T.; Meiselman, M. R.; Cowan, N.; Dickinson, M. H.; Yapici, N.; Stern, D. L.; Shirangi, T.; Cohen, I.

10.1101/2022.02.22.481344 — animal behavior and cognition — Posted on 2022-04-11

2371 Allopatric divergence of cooperators confers cheating resistance and limits the effects of a defector mutation

Schaal, K. A.; Yu, Y.-T. N.; Vasse, M.; Velicer, G. J.

10.1101/2021.01.07.425765 — evolutionary biology — Posted on 2022-04-11

2372 Positive fitness effects help explain the broad range of Wolbachia prevalences in natural populations

Karisto, P.; Duplouy, A.; de Vries, C.; Kokko, H.

10.1101/2022.04.11.487824 — ecology — Posted on 2022-04-11

2373 Condensation of LINE-1 is required for retrotransposition

Sil, S.; Boeke, J. D.; Holt, L. J.

10.1101/2022.04.11.487880 — cell biology — Posted on 2022-04-11

2374 The isoforms of pyruvate kinase act as nutrient sensors for the β-cell KATP channel

Foster, H. R.; Ho, T.; Potapenko, E.; Sdao, S. M.; Lewandowski, S. L.; VanDeusen, H. R.; Davidson, S. M.; Cardone, R. L.; Kibbey, R. G.; Merrins, M. J.

10.1101/2022.02.09.478817 — cell biology — Posted on 2022-04-11

2375 Every individual makes a difference: A trinity derived from linking individual brain morphometry, connectivity and mentalising ability

Li, Z.; Dong, Q.; Hu, B.; Wu, H.

10.1101/2022.04.11.487870 — neuroscience — Posted on 2022-04-11

2376 Neuronal activity regulates Matrin 3 levels and function in a calcium-dependent manner through calpain cleavage and calmodulin binding

Malik, A. M.; Wu, J. J.; Gillies, C. A.; Doctrove, Q. A.; Li, X.; Huang, H.; Shakkottai, V. G.; Barmada, S.

10.1101/2022.04.11.487904 — neuroscience — Posted on 2022-04-11

2377 Neural mass modelling for the masses: Democratising access to whole-brain biophysical modelling with FastDMF

Herzog, R.; Mediano, P.; Rosas, F. E.; Luppi, A. I.; Perl, Y. S.; Tagliazucchi, E.; Kringelbach, M. L.; Cofre, R.; Deco, G.

10.1101/2022.04.11.487903 — neuroscience — Posted on 2022-04-11

2378 A Neurodynamic Model of Inter-Brain Coupling in the Gamma Band

Moreau, Q.; Adel, L.; Douglas, C.; Ranjbaran, G.; Dumas, G.

10.1101/2022.04.08.487686 — neuroscience — Posted on 2022-04-11

2379 Expansive Linguistic Representations to Predict Interpretable Odor Mixture Discriminability

dhurandhar, a.; Cecchi, G.; meyer, p.

10.1101/2022.04.11.487927 — neuroscience — Posted on 2022-04-11

2380 Between-area communication through the lens of within-area neuronal dynamics

Gozel, O.; Doiron, B.

10.1101/2022.04.11.487906 — neuroscience — Posted on 2022-04-11

2381 Mapping inter-individual functional connectivity variability in TMS targets for major depressive disorder

Harita, S.; Momi, D.; Mazza, F.; Griffiths, J. D.

10.1101/2021.07.15.452518 — neuroscience — Posted on 2022-04-11

2382 A maximum mean discrepancy approach reveals subtle changes in α-synuclein dynamics

Verdier, H.; Laurent, F.; Casse, A.; Vestergaard, C. L.; Specht, C. G.; Masson, J.-B.

10.1101/2022.04.11.487825 — biophysics — Posted on 2022-04-11

2383 Phylogenetic-informed graph deep learning to classify dynamic transmission clusters in infectious disease epidemics

Sun, C.; Li, Y.; Marini, S.; Riva, A.; Wu, D. O.; Salemi, M.; Magalis, B. R.

10.1101/2022.04.10.487587 — bioinformatics — Posted on 2022-04-11

2384 Protein engineering approach to enhance activity assays of mono-ADP-ribosyltransferases through proximity

Galera-Prat, A.; Alaviuhkola, J.; Alanen, H. I.; Lehtiö, L.

10.1101/2022.04.11.487883 — biochemistry — Posted on 2022-04-11

2385 Isolation and Divergence of Peromyscus melanotis Populations Across the Madrean Sky Islands in Arizona

Larsen, B. B.; Otto, H. W.; Gryseels, S.; Worobey, M.

10.1101/2022.04.11.487881 — evolutionary biology — Posted on 2022-04-11

2386 Novel frontier in wildlife monitoring: identification of small rodent species from faecal pellets using Near-Infrared Reflectance Spectroscopy (NIRS)

Tuomi, M. W.; Murguzur, F. J. A.; Hoset, K. S.; Soininen, E. M.; Vesterinen, E. J.; Utsi, T. A.; Kaino, S.; Brathen, K. A.

10.1101/2022.04.11.487830 — ecology — Posted on 2022-04-11

2387 METTL3 regulates breast cancer-associated alternative splicing switches

Achour, C.; Groza, P.; Bhattarai, D. P.; Roman, A. C.; Aguilo, F.

10.1101/2022.04.11.487899 — cell biology — Posted on 2022-04-11

2388 Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target

Wagner, M. P.; Formaglio, P.; Gorgette, O.; Dziekan, J. M.; Huon, C.; Berneburg, I.; Rahlfs, S.; Barale, J.-C.; Feinstein, S. I.; Fisher, A. B.; Menard, D.; Bozdech, Z.; Amino, R.; Touqui, L.; Chitnis, C. E.

10.1101/2022.04.11.487889 — cell biology — Posted on 2022-04-11

2389 Endogenous viral elements reveal associations between a non-retroviral RNA virus and symbiotic dinoflagellate genomes

Veglia, A. J.; Bistolas, K. S. I.; Tara Pacific Consortium, ; Correa, A. S.; Thurber, R. V.

10.1101/2022.04.11.487905 — microbiology — Posted on 2022-04-11

2390 Brainstem speech encoding is dynamically shaped online by fluctuations in cortical α state

Lai, J.; Price, C. N.; Bidelman, G. M.

10.1101/2022.04.11.487894 — neuroscience — Posted on 2022-04-11

2391 Overcoming the Reproducibility Crisis - Results of the first Community Survey of the German National Research Data Infrastructure for Neuroscience.

Klingner, C.; Denker, M.; Grün, S.; Hanke, M.; Oeltze-Jafra, S.; Ohl, F. W.; Radny, J.; Rotter, S.; Scherberger, H.; Stein, A.; Wachtler, T.; Witte, O. W.; Ritter, P.

10.1101/2022.04.07.487439 — neuroscience — Posted on 2022-04-11

2392 Variation in subcortical anatomy: relating interspecies differences, heritability, and brain-behavior relationships

Blostein, N.; Devenyi, G. A.; Patel, S.; Patel, R.; Tullo, S.; Plitman, E.; Costantino, M.; Markello, R.; Parent, O.; Bedford, S. A.; Sherwood, C. C.; Hopkins, W. D.; Seidlitz, J.; Raznahan, A.; Chakravarty, M.

10.1101/2022.04.11.487874 — neuroscience — Posted on 2022-04-11

2393 Genome-scale metabolic modelling enables deciphering ethanol metabolism via the acrylate pathway in the propionate-producer Anaerotignum neopropionicum

Benito-Vaquerizo, S.; Parera Olm, I.; de Vroet, T.; Schaap, P. J.; Sousa, D. Z.; Martins dos Santos, V. A. P.; Suarez-Diez, M.

10.1101/2022.04.11.487872 — systems biology — Posted on 2022-04-11

2394 Linker histone H1 regulates defense priming and immunity in plants

Hirt, H.; Sheikh, A.; Nawaz, K.; Tabassum, N.; Almeida-Trapp, M.; Alhoraibi, H.; Rayapuram, N.

10.1101/2022.04.11.487821 — plant biology — Posted on 2022-04-11

2395 Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis

Cloud, A. S.; McWilliams, M. M.; Koohestani, F.; Ganeshkumar, S.; Gunewardena, S.; Graham, A.; Nothnick, W. B.; Chennathukuzhi, V. M.

10.1101/2022.04.11.487902 — physiology — Posted on 2022-04-11

2396 Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability in cancer

Li, Z.; Ferguson, L.; Deol, K. K.; Roberts, M. A.; Magtanong, L.; Bassik, M. C.; Dixon, S. J.; Ingolia, N.; Olzmann, J.

10.1101/2022.04.11.487892 — cancer biology — Posted on 2022-04-11

2397 Short-course but not prolonged treatment with ATR inhibitor AZD6738 integrates with radiotherapy to generate a tumor antigen-specific CD8+ T cell expansion in the periphery

Vendetti, F. P.; Clump, D. A.; Schamus-Haynes, S.; DiMayorca, M.; Islam, N.; Chang, J.; Beumer, J. H.; Bakkenist, C. J.

10.1101/2022.04.11.487886 — cancer biology — Posted on 2022-04-11

2398 Single-cell colocalization analysis using a deep generative model

Kojima, Y.; Mii, S.; Hayashi, S.; Hirose, H.; Ishikawa, M.; Akiyama, M.; Enomoto, A.; Shimamura, T.

10.1101/2022.04.10.487815 — bioinformatics — Posted on 2022-04-11

2399 ReDisX: a Continuous Max Flow-based framework to redefine the diagnosis of diseases based on identified patterns of genomic signatures

YIP, H. F.; Chowdhury, D.; Wang, K.; Liu, Y.; Gao, Y.; Lan, L.; Zheng, C.; Guan, D.; Lam, K. F.; Zhu, H.; Tai, X.; Lu, A.

10.1101/2022.04.11.487592 — bioinformatics — Posted on 2022-04-11

2400 Tomographic-encoded multiphoton (TEMP) microscopy

He, H.; Dong, X.; Ren, Y.-X.; Lai, C. S. W.; Tsia, K. K.; Wong, K. K. Y.

10.1101/2022.04.11.487875 — bioengineering — Posted on 2022-04-11

2401 The conserved centrosomal motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC).

Rale, M. J.; Romer, B.; Mahon, B. P.; Travis, S. M.; Petry, S.

10.1101/2022.04.11.487887 — biochemistry — Posted on 2022-04-11

2402 Privacy-Preserving Statistical Analysis of Genomic Data using Compressive Mechanism with Haar Wavelet Transform

Yamamoto, A.; Shibuya, T.

10.1101/2022.04.10.487816 — genomics — Posted on 2022-04-11

2403 Using large soybean historical data to study genotype by environment variation and identify mega-environments with the integration of genetic and non-genetic factors

Dalsente Krause, M.; Olimpio das Gracas Dias, K.; Singh, A. K.; Beavis, W. D.

10.1101/2022.04.11.487885 — genetics — Posted on 2022-04-11

2404 Plant protection habits among Hungarian farmers and garden owners and their implications for pollinator protection

Varga-Szilay, Z.; Pozsgai, G.

10.1101/2022.04.07.487523 — ecology — Posted on 2022-04-11

2405 Identification of a novel AP2 transcription factor in zygotes with an essential role in Plasmodium ookinete development.

Nishi, T.; Iwanaga, S.; Kaneko, I.; Yuda, M.

10.1101/2022.04.11.487829 — microbiology — Posted on 2022-04-11

2406 Core and accessory effectors of type VI secretion systems contribute differently to the intraspecific diversity of Pseudomonas aeruginosa

Habich, A.; Galeev, A.; Chaves Vargas, V.; Vogler, O.; Ghoul, M.; Andersen, S. B.; Johansen, H. K.; Molin, S.; Griffin, A. S.; Unterweger, D.

10.1101/2022.04.11.487527 — microbiology — Posted on 2022-04-11

2407 From Specification to Implementation: Assume-Guarantee Contracts for Synthetic Biology

Pandey, A.; Incer, I.; Sangiovanni-Vincentelli, A.; Murray, R. M.

10.1101/2022.04.08.487709 — synthetic biology — Posted on 2022-04-11

2408 Substance P and adenosine signaling pathways regulate exosomal sorting of miR-21 in colonic epithelial cells

Wani, S.; Law, I. K. M.; Bugwadia, A. K.; Hoffman, J. M.; Pothoulakis, C.

10.1101/2022.03.30.486482 — cell biology — Posted on 2022-04-11

2409 SARS-CoV-2 RdRp uses NDPs as a substrate and is able to incorporate NHC into RNA from diphosphate form molnupiravir

Wang, M.; Wu, C.; Liu, N.; Zhang, F.; Dong, H.; Wang, S.; Chen, M.; Jiang, X.; Gu, L.

10.1101/2021.11.15.468737 — molecular biology — Posted on 2022-04-11

2410 Erythropoietin supplementation ameliorates the immunological and hematological deficiencies of lysinuric protein intolerance in mice

Giroud-Gerbetant, J.; Sotillo, F.; Couso, J.; Zorzano, A.; Sanchez, M.; Weiss, G.; Palacin, M.; Bodoy, S.

10.1101/2021.08.15.456393 — molecular biology — Posted on 2022-04-11

2411 An environmentally responsive transcriptional state modulates cell identities during root development

Oliva, M.; Stuart, T.; Tang, D.; Pflueger, J.; Poppe, D.; Jabbari, J. S.; Gigante, S.; Dragwidge, J. M.; Whelan, J.; Lewsey, M. G.; Lister, R.

10.1101/2022.03.04.483008 — plant biology — Posted on 2022-04-11

2412 DeepPerVar: a multimodal deep learning framework for functional interpretation of genetic variants in personal genome

Chen, L.; Wang, Y.

10.1101/2022.04.10.487809 — bioinformatics — Posted on 2022-04-11

2413 Novel Antibody Interfaces Revealed Through Structural Mining

Yin, Y.; Romei, M.; Sankar, K.; Pal, L. R.; Hoi, K. H.; Yang, Y.; Leonard, B.; Boenig, G. D. L.; Kumar, N.; Matsumoto, M.; Payandeh, J.; Harris, S. F.; Moult, J.; Lazar, G. A.

10.1101/2022.04.06.487381 — biochemistry — Posted on 2022-04-11

2414 Symbiosis between Patescibacteria and Archaea discovered in wastewater-treating bioreactors

Kuroda, K.; Yamamoto, K.; Nakai, R.; Hirakata, Y.; Kubota, K.; Nobu, M. K.; Narihiro, T.

10.1101/2022.04.10.487813 — microbiology — Posted on 2022-04-11

2415 CAPG is required for Ebola virus infection by controlling virus egress from infected cells.

Mori, H.; Connell, J. M.; Donahue, C. J.; Boytz, R.; Patten, J.; Leung, D. W.; Lacount, D. J.; Davey, R. A.

10.1101/2022.04.10.487814 — microbiology — Posted on 2022-04-11

2416 Sleep Disruption Selectively Weakens Reactivated Memories

Whitmore, N. W.; Paller, K. A.

10.1101/2022.04.10.487316 — neuroscience — Posted on 2022-04-11

2417 The Interplay of Attention and Conscious Perception: Evidence from Human Intracerebral Recordings and Computational Modeling

Liu, J.; Bayle, D. J.; Spagna, A.; Sitt, J. D.; Bourgeois, A.; Lehongre, K.; Fernandez-Vidal, S.; Navarro, V.; Adam, C.; Lambrecq, V.; Malkinson, T. S.; Bartolomeo, P.

10.1101/2022.04.10.487690 — neuroscience — Posted on 2022-04-11

2418 Efficient evolution of human antibodies from general protein language models and sequence information alone

Hie, B. L.; Xu, D.; Shanker, V. R.; Bruun, T. U.; Weidenbacher, P. A.; Tang, S.; Kim, P. S.

10.1101/2022.04.10.487811 — synthetic biology — Posted on 2022-04-11

2419 A cross-sectional study of the commercial plant-based landscape across the US, UK and Canada.

Guess, N.; Klatt, K.; Wei, D.; Williamson, E.; Ulgenalp, I.; Trinidade, O.; Kusaslan, E.; Yilidrim, A.; Gowers, C.; Guard, R.; Mills, C.

10.1101/2022.04.08.487708 — scientific communication and education — Posted on 2022-04-11

2420 First crystal structure of a non-canonical amino acid linked to a paramagnetic lanthanide tag facilitates protein structure determination using NMR-derived restraints

Okwei, E. N. N.; Ganguly, S.; Darling, H. L.; Harp, J. M.; Gulsevin, A.; Coin, I.; Mchaourab, H.; Ledwitch, K.; Kuenze, G.; Meiler, J.

10.1101/2022.04.10.487812 — biophysics — Posted on 2022-04-11

2421 wenda_gpu: fast domain adaptation for genomic data

Hippen, A. A.; Crawford, J.; Gardner, J. R.; Greene, C. S.

10.1101/2022.04.09.487671 — bioinformatics — Posted on 2022-04-11

2422 Whole-genome duplication in an algal symbiont serendipitously confers thermal tolerance to corals

Dougan, K. E.; Bellantuono, A. J.; Kahlke, T.; Abbriano, R. M.; Chen, Y.; Shah, S.; Granados-Cifuentes, C.; van Oppen, M. J. H.; Bhattacharya, D.; Suggett, D. J.; Chan, C. X.; Rodriguez-Lanetty, M.

10.1101/2022.04.10.487810 — genomics — Posted on 2022-04-11

2423 Contrasting effects of reduced phosphatidylcholine synthesis in absence of seipin: embryonic lethality goes down while lipid droplets get even larger

Zhu, J.; Lam, S. M.; Yang, L.; Liang, J.; Ding, M.; Shui, G.; Huang, X.

10.1101/2022.04.10.487805 — developmental biology — Posted on 2022-04-11

2424 Antibiotic action revealed by real-time imaging of the mycobacterial membrane

Wuo, M. G.; Dulberger, C. L.; Brown, R. A.; Sturm, A.; Ultee, E.; Bloom-Ackermann, Z.; Choi, C.; Garner, E. C.; Briegel, A.; Hung, D. T.; Rubin, E. J.; Kiessling, L. L.

10.1101/2022.01.07.475452 — microbiology — Posted on 2022-04-11

2425 Larger and more dentated hippocampal structure is associated with better memory in the oldest-old.

Parpura, V.; Caceres, H.; Sims, S.; Ver Hoef, L.; Ramaniharan, A. K.; Merritt, S.; Rezaei, R. F.; Bharadwaj, P. K.; Franchetti, M. K.; Raichlen, D. A.; Jessup, C. J.; Hinshaw, A. G.; Van Etten, E. J.; Trouard, T. P.; Geldmacher, D. S.; Wadley, V. G.; Alperin, N.; Porges, E. S.; Woods, A. J.; Cohen, R. A.; Levin, B. E.; Rundek, T.; Alexander, G. E.; Visscher, K. M.

10.1101/2022.04.10.487750 — neuroscience — Posted on 2022-04-11

2426 An experimental test of chronic traffic noise exposure on parental behaviour and reproduction in zebra finches

Liu, Q.; Fontein, K.; Gelok, E. J.; Slabbekoorn, H.; Riebel, K.

10.1101/2021.11.30.470558 — animal behavior and cognition — Posted on 2022-04-11

2427 Modeling microRNA-driven post-transcriptional regulation by using exon-intron split analysis (EISA) in pigs

Marmol-Sanchez, E.; Cirera, S.; Zingaretti, L.; Jacobsen, M. J.; Ramayo-Caldas, Y.; Jorgensen, C. B.; Fredholm, M.; Cardoso, T. F.; Quintanilla, R.; Amills, M.

10.1101/2021.07.14.452370 — genomics — Posted on 2022-04-11

2428 Population bottleneck has only marginal effect on fitness evolution and its repeatability in dioecious C. elegans

Bisschop, K.; Blankers, T.; Mariën, J.; Wortel, M. T.; Egas, M.; Groot, A. T.; Visser, M.; Ellers, J.

10.1101/2021.10.07.463474 — evolutionary biology — Posted on 2022-04-11

2429 INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

Woolley, J. F.; Chen, K.; Saffi, G. T.; Genc, G. E.; Lee, D. K. C.; Dzneladze, I.; He, R.; Chow, J. T.-S.; Gabra, M. M.; Son, M. H.; Melo, C. M. P.; Newell, C. A.; He, A.; Schoof, E. M.; Xie, S. Z.; Mangialardi, E. M.; Kotlyar, M.; Rashid, A.; Gams, M. S.; Vacher, J.; Guidos, C. J.; Jurisica, I.; Dick, J. E.; Botelho, R. J.; Minden, M. D.; Salmena, L.

10.1101/2021.03.25.437029 — cancer biology — Posted on 2022-04-11

2430 Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury

Tan, C.; Norden, P. R.; Liu, T.; Ujiie, N.; Yan, X.; Aoto, K.; Ortega, S.; De Plaen, I. G.; Kume, T.

10.1101/2022.03.03.482713 — molecular biology — Posted on 2022-04-11

2431 Voltage-Sensing Phosphatase (VSP) Regulates Endocytosis-Dependent Nutrient Absorption in Chordate Enterocytes

Ratanayotha, A.; Matsuda, M.; Kimura, Y.; Takenaga, F.; Mizuno, T.; Hossain, M. I.; Higashijima, S.-i.; Kawai, T.; Ogasawara, M.; Okamura, Y.

10.1101/2022.03.10.483738 — cell biology — Posted on 2022-04-11

2432 On demand nanoliter sampling probe for collection of brain fluid

Teixidor, J.; Novello, S.; Ortiz, D.; Menin, L.; Lashuel, H. A.; Bertsch, A.; Renaud, P.

10.1101/2022.04.08.487549 — neuroscience — Posted on 2022-04-11

2433 Feature-reweighted representational similarity analysis: A method for improving the fit between computational models, brains, and behavior

Kaniuth, P.; Hebart, M. N.

10.1101/2021.09.27.462005 — neuroscience — Posted on 2022-04-11

2434 A silent disco: Persistent entrainment of low-frequency neural oscillations underlies beat-based, but not pattern-based temporal expectations

Bouwer, F. L.; Fahrenfort, J. J.; Millard, S. K.; Kloosterman, N. A.; Slagter, H. A.

10.1101/2020.01.08.899278 — neuroscience — Posted on 2022-04-11

2435 The Impact of Multivesicular Release on the Transmission of Sensory Information by Ribbon Synapses

James, B.; Piekarz, P.; Moya-Diaz, J.; Lagnado, L.

10.1101/2021.11.04.467256 — neuroscience — Posted on 2022-04-11

2436 An open-source tool to assess the carbon footprint of research

Mariette, J.; Blanchard, O.; Berne, O.; Aumont, O.; Carrey, J.; Ligozat, A.-L.; Lellouch, E.; Roche, P. E.; Guennebaud, G.; Thanwerdas, J.; Bardou, P.; Salin, G.; Maigne, E.; Servan, S.; Ben Ari, T.

10.1101/2021.01.14.426384 — scientific communication and education — Posted on 2022-04-11

2437 Heterogeneity of circulating epithelial cells in breast cancer at single-cell resolution: identifying tumor and hybrid cells

Menyailo, M. E.; Zainullina, V. R.; Tashireva, L. A.; Zolotareva, S. Y.; Gerashchenko, T. S.; Alifanov, V. V.; Savelieva, O. E.; Grigoryeva, E. S.; Tarabanovskaya, N. A.; Popova, N. O.; Khozyainova, A. A.; Choinzonov, E. L.; Cherdyntseva, N. V.; Perelmuter, V. M.; Denisov, E. V.

10.1101/2021.11.24.469962 — cancer biology — Posted on 2022-04-11

2438 Learning-related contraction of grey matter in rodent sensorimotor cortex is associated with adaptive myelination

Mediavilla, T.; Özalay, O.; Estevez-Silva, H. M.; Frias, B.; Orädd, G.; Sultan, F.; Brozzoli, C.; Garzon, B.; Lövden, M.; Marcellino, D.

10.1101/2022.04.06.487330 — neuroscience — Posted on 2022-04-11

2439 Deep learning from multiple experts improves identification of amyloid neuropathologies

Wong, D. R.; Tang, Z.; Mew, N. C.; Das, S.; Athey, J.; McAleese, K. E.; Kofler, J. K.; Flanagan, M. E.; Borys, E.; White, C. L.; Butte, A. J.; Dugger, B. N.; Keiser, M. J.

10.1101/2021.03.12.435050 — pathology — Posted on 2022-04-10

2440 In situ single particle classification reveals distinct 60S maturation intermediates in cells

Lucas, B. A.; Zhang, K.; Loerch, S.; Grigorieff, N.

10.1101/2022.04.10.487797 — biophysics — Posted on 2022-04-10

2441 Puf3p facilitates fermentative mitochondrial functions via monosome-enriched nuclear-encoded mitochondrial mRNAs in budding yeast

Hayashi, S.; Iwamoto, K.; Yoshihisa, T.

10.1101/2022.04.10.487782 — molecular biology — Posted on 2022-04-10

2442 Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies

Banks, R. A.; Galstyan, V.; Lee, H. J.; Hirokawa, S.; Ierokomos, A.; Ross, T. D.; Bryant, Z.; Thomson, M.; Phillips, R.

10.1101/2021.10.22.465381 — biophysics — Posted on 2022-04-10

2443 Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor

Islam, S. M. A.; Diaz-Gay, M.; Wu, Y.; Barnes, M.; Vangara, R.; Bergstrom, E. N.; He, Y.; Vella, M.; Wang, J.; Teague, J. W.; Clapham, P.; Moody, S.; Senkin, S.; Li, Y. R.; Riva, L.; Zhang, T.; Gruber, A. J.; Steele, C. D.; Otlu, B.; Khandekar, A.; Abbasi, A.; Humphreys, L.; Syulyukina, N.; Brady, S. W.; Alexandrov, B. S.; Pillay, N.; Zhang, J.; Adams, D. J.; Marticorena, I.; Wedge, D. C.; Landi, M. T.; Brennan, P.; Stratton, M. R.; Rozen, S. G.; Alexandrov, L. B.

10.1101/2020.12.13.422570 — bioinformatics — Posted on 2022-04-10

2444 The role of mitochondrial energetics in the origin and diversification of eukaryotes

Schavemaker, P. E.; Munoz-Gomez, S. A.

10.1101/2021.10.23.465364 — evolutionary biology — Posted on 2022-04-10

2445 A Lethal Genetic Incompatibility between Naturally Hybridizing Species in Mitochondrial Complex I

Moran, B. M.; Payne, C. Y.; Powell, D. L.; Iverson, E. N.; Banerjee, S. M.; Madero, A.; Gunn, T. R.; Langdon, Q. K.; Liu, F.; Matney, R.; Singhal, K.; Leib, R. D.; Hernandez-Perez, O.; Corbett-Detig, R.; Frydman, J.; Schartl, M.; Havird, J. C.; Schumer, M.

10.1101/2021.07.13.452279 — evolutionary biology — Posted on 2022-04-10

2446 Robust and efficient online auditory psychophysics

Zhao, S.; Brown, C. A.; Holt, L. L.; Dick, F.

10.1101/2021.07.17.452796 — neuroscience — Posted on 2022-04-10

2447 Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Bollmann, S.; Mattern, H.; Bernier, M.; Robinson, S. R.; Park, D.; Speck, O.; Polimeni, J. R.

10.1101/2021.06.09.447807 — neuroscience — Posted on 2022-04-10

2448 Predicting compound activity from phenotypic profiles and chemical structures

Moshkov, N.; Becker, T.; Yang, K.; Horvath, P.; Dancik, V. C.; Wagner, B. K.; Clemons, P. C.; Singh, S.; Carpenter, A. E.; Caicedo, J. C.

10.1101/2020.12.15.422887 — bioinformatics — Posted on 2022-04-10

2449 An EcR probe reveals mechanisms of the ecdysone-mediated switch from repression-to-activation on target genes in the larval wing disc

Wardwell-Ozgo, J.; Terry, D. E.; Schweibenz, C. K.; Tu, M. Z.; Soliman, O.; Schofield, D.; Moberg, K.

10.1101/2022.04.07.487542 — developmental biology — Posted on 2022-04-10

2450 The effect of different treatment durations with indole-3-acetic acid (IAA)-producing endophytic Bacillus spp. on tomato 'Aicha' under saline conditions

Belaouni, H. A.; Dif, G.; Toumatia, O.; Meklat, A.; Mathieu, F.; Zitouni, A.

10.1101/2022.04.10.487795 — microbiology — Posted on 2022-04-10

2451 Synaptic vesicle-bound molecular bridges organize sequential vesicle states along parallel pathways

Papantoniou, C.; Laugks, U.; Betzin, J.; Capitanio, C.; Ferrero, J. J.; Sanchez-Prieto, J.; Schoch, S.; Brose, N.; Baumeister, W.; Cooper, B. H.; Imig, C.; Lucic, V.

10.1101/2022.04.10.487799 — neuroscience — Posted on 2022-04-10

2452 Visual Mode Switching: Improved General Compensation to Environmental Color Change Requires Only One Exposure Per Day

Li, Y.; Tregillus, K. E.; Engel, S. A.

10.1101/2022.04.10.487784 — neuroscience — Posted on 2022-04-10

2453 An interplay between JA and SA modulates rapid systemic ROS signaling during responses to high light stress or wounding

Myers, R. J.; Fichman, Y.; Mittler, R.

10.1101/2022.04.10.487802 — plant biology — Posted on 2022-04-10

2454 A chemomechanical model of sperm locomotion reveals two modes of swimming

Li, C.; Chakrabarti, B.; Castilla, P.; Mahajan, A.; Saintillan, D.

10.1101/2022.04.10.487801 — biophysics — Posted on 2022-04-10

2455 Microbial Community Dynamics of a Sequentially Fed Anaerobic Digester Treating Solid Organic Waste

Lee, H.; Fitamo, T. M.; Nesbo, C. L.; Guildford, N. G. H.; Kanger, K.; Yang, M. I.; Edwards, E. A.

10.1101/2022.04.10.487789 — bioengineering — Posted on 2022-04-10

2456 MPI region of interest (ROI) analysis and quantification of iron in different volumes

Sehl, O. C.; Tiret, B.; Berih, M. A.; Makela, A. V.; Goodwill, P.; Foster, P. J.

10.1101/2022.04.10.487778 — biophysics — Posted on 2022-04-10

2457 Periodic Environmental Disturbance Drives Repeated Ecomorphological Diversification in an Adaptive Radiation of Antarctic Fishes

Parker, E.; Zapfe, K. L.; Yadav, J.; Frederich, B.; Jones, C. D.; Economo, E. P.; Federman, S.; Near, T. J.; Dornburg, A.

10.1101/2022.04.08.487509 — evolutionary biology — Posted on 2022-04-10

2458 multiplestressR: An R package to analyse factorial multiple stressor data using the additive and multiplicative null models

Burgess, B. J.; Murrell, D. J.

10.1101/2022.04.08.487622 — ecology — Posted on 2022-04-10

2459 HiFENS: High-throughput FISH detection of endogenous pre-mRNA splicing isoforms

Shilo, A.; Pegoraro, G.; Misteli, T.

10.1101/2022.04.10.487792 — cell biology — Posted on 2022-04-10

2460 Unexpected proteinopathies in hippocampal PDE11A4 promote age-related cognitive decline of social associative memories

Pilarzyk, K. (; Porcher, L.; Capell, W. R.; Burbano, S. D.; Davis, J.; Fisher, J.; Gorny, N.; Petrolle, S.; Kelly, M. P.

10.1101/2022.04.08.487696 — neuroscience — Posted on 2022-04-10

2461 Peptide-RNA Coacervates as a Cradle for the Evolution of Folded Domains

Seal, M.; Weil-Ktorza, O.; Despotovic, D.; S Tawfik, D.; Levy, Y.; Metanis, N.; M Longo, L.; Goldfarb, D.

10.1101/2022.04.10.487755 — biophysics — Posted on 2022-04-10

2462 Inferring microRNA regulation: A proteome perspective

Ofer, D.; Linial, M.

10.1101/2022.04.09.487727 — bioinformatics — Posted on 2022-04-10

2463 IMPatienT: an integrated web application to digitize, process and explore multimodal patient data.

Meyer, C.; Romero, N.; Evangelista, T.; Cadot, B.; Laporte, J.; Jeannin-Girardon, A.; Collet, P.; Chennen, K.; Poch, O.

10.1101/2022.04.08.487635 — bioinformatics — Posted on 2022-04-10

2464 CHD-associated enhancers shape human cardiomyocyte lineage commitment

Armendariz, D. A.; Goetsch, S. C.; Wang, Y.; Xie, S.; Munshi, N. V.; Hon, G. C.

10.1101/2022.04.07.487515 — genomics — Posted on 2022-04-10

2465 Environmental filtering and habitat (mis)matching of riverine invertebrate metacommunities

Murray-Stoker, D.; Murray-Stoker, K. M.; Kong, F. P.; Amanat, F.

10.1101/2022.04.09.487317 — ecology — Posted on 2022-04-10

2466 Investigating tri-trophic interactions using bio-energetic demographic models

Passoni, G.; Coulson, T.; Cagnacci, F.; Hudson, P. J.; Stahler, D. R.; Smith, D. W.; Lachish, S.

10.1101/2022.04.07.487507 — ecology — Posted on 2022-04-10

2467 Ecological and evolutionary drivers of phenotypic and genetic variation in the European crabapple (Malus sylvestris (L.) Mill.), a wild relative of the cultivated apple

chen, x. X.; avia, k. K.; forler, a. A.; remoue, c. C.; venon, a. A.; rousselet, a. A.; lucas, g. G.; rover, l. L.; kwarteng, A. A.; le-guilloux, m. M.; belcram, h. H.; combes, v. V.; olvera-vazquez, s. S.; falque, m. A.; Alins, g. G.; kirisits, t. T.; ursu, t. T.; roman, a. A.; volk, g. G.; bazot, s. S.; cornille, a. A.

10.1101/2022.04.09.487746 — ecology — Posted on 2022-04-10

2468 Growth form matters: crustose lichens are sensitive to forest management on dead wood

Kantelinen, A.; Purhonen, J.; Halme, P.; Myllys, L.

10.1101/2022.04.08.487685 — ecology — Posted on 2022-04-10

2469 K2P channel TWK-40 Regulates a Rhythmic Behavior in C. elegans

Yue, Z.; Zhang, Y.; Yu, B.; Xu, Y.; Chen, L.; Li, Y.; Chitturi, J.; Meng, J.; Hung, W.; Boulin, T.; Zhen, M.; Gao, S.

10.1101/2022.04.09.487752 — neuroscience — Posted on 2022-04-10

2470 A Spiking Neural Network Model for the Control of Oscillatory Phase Differences Between Multiple Brain Areas

Canolty, R. T.; Stimberg, M. T.

10.1101/2022.04.08.487667 — neuroscience — Posted on 2022-04-10

2471 Assessing TMS-evoked cognitive network responses depending on neurocognitive and oscillatory brain state: A simultaneous TMS-EEG-fMRI project

Janssens, S. E. W.; de Graaf, T. A.; Duecker, F.; Schuhmann, T.; Sack, A. T.

10.1101/2022.04.07.487517 — neuroscience — Posted on 2022-04-10

2472 A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions

Kira, S.; Safaai, H.; Morcos, A. S.; Panzeri, S.; Harvey, C. D.

10.1101/2022.04.10.487349 — neuroscience — Posted on 2022-04-10

2473 Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis

Baskaran, P.; Mihaylov, S. R.; Vinsland, E.; Shah, K.; Granat, L.; Ultanir, S. K.; Tee, A. R.; Murn, J.; Bateman, J. M.

10.1101/2022.04.08.487575 — neuroscience — Posted on 2022-04-10

2474 Mechanistic Neural Mass Modeling: from physiology to pathophysiological brain activity

Tripathi, R.; Gluckman, B. J.

10.1101/2022.04.09.487500 — neuroscience — Posted on 2022-04-10

2475 Intrinsically photosensitive retinal ganglion cells evade temporal filtering to encode environmental light intensity

Sabbah, S.; Papendorp, C.; Behrendt, I.; Rasras, H.; Cann, J.; Leyrer, M. L.; Koplas, E.; Beltoja, M.; Etebari, C.; Gunesch, A. N.; Carrete, L.; Kim, M. T.; Manoff, G.; Bhatia-Lin, A.; Zhao, T.; Dowling, H.; Briggman, K. L.; Berson, D. M.

10.1101/2022.04.09.487733 — neuroscience — Posted on 2022-04-10

2476 Polymer physics-based classification of neurons

Choi, K.; Kim, W. K.; Hyeon, C.

10.1101/2022.04.07.487455 — neuroscience — Posted on 2022-04-10

2477 Hypothalamic gene network dysfunction is associated with cognitive decline and body weight loss in Alzheimer's disease mice

Dai, M.; Dunn, A. R.; Hadad, N.; Zhang, J.-G.; Poirion, O. B.; Korgan, A. C.; White, B. S.; Philip, V.; Neuner, S. M.; O'Connell, K. M. S.; Kaczorowski, C. C.

10.1101/2022.04.08.487664 — neuroscience — Posted on 2022-04-10

2478 Learning-related congruent and incongruent changes of excitation and inhibition in distinct cortical areas

Esmaeili, V.; Oryshchuk, A.; Asri, R.; Tamura, K.; Foustoukos, G.; Liu, Y.; Guiet, R.; Crochet, S.; Petersen, C. C.

10.1101/2022.04.10.487780 — neuroscience — Posted on 2022-04-10

2479 Polerovirus N-terminal readthrough domain structures reveal novel molecular strategies for mitigating virus transmission by aphids

Schiltz, C. J.; Wilson, J. R.; Hosford, C. J.; Adams, M. C.; Preising, S. E.; DeBlasio, S. L.; Macleod, H. J.; Van Eck, J.; Heck, M. L.; Chappie, J. S.

10.1101/2022.04.10.487772 — plant biology — Posted on 2022-04-10

2480 Saccades are locked to the phase of alpha oscillations during natural reading

Pan, Y.; Popov, T.; Frisson, S.; Jensen, O.

10.1101/2022.04.10.487681 — physiology — Posted on 2022-04-10

2481 Probing the Drug Dynamics and Mode-of-Action of Chemotherapeutics Using Metasurface-Enhanced Infrared Reflection Spectroscopy of Live Cells

Shen, P.-T.; Huang, S. H.; Huang, Z.; Wilson, J. J.; Shvets, G.

10.1101/2022.04.08.487683 — biophysics — Posted on 2022-04-10

2482 NS1 from Two Zika Virus Strains Differently Interact with a Membrane: A Plausible Explanation for their Differential Virulence

Poveda Cuevas, S. A.; Barroso da Silva, F. L.; Etchebest, C.

10.1101/2022.04.08.487413 — bioinformatics — Posted on 2022-04-10

2483 Weighted Kernels Improve Multi-Environment Genomic Prediction

Hu, X.; Carver, B. F.; El-Kassaby, Y. A.; Zhu, L.; Chen, C.

10.1101/2022.04.10.487783 — bioinformatics — Posted on 2022-04-10

2484 DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks

Hallgren, J.; Tsirigos, K.; Damgaard Pedersen, M.; Almagro Armenteros, J. J.; Marcatili, P.; Nielsen, H.; Krogh, A.; Winther, O.

10.1101/2022.04.08.487609 — bioinformatics — Posted on 2022-04-10

2485 Sequence Analysis of WRKY Transcription Factor Family in Dendrobium officinale

Pan, H.; Feng, Y.; Wei, L.; Sun, X.; Tao, S.; Song, C.

10.1101/2022.04.10.487774 — bioinformatics — Posted on 2022-04-10

2486 TIGER: A Web Portal of Tumor Immunotherapy Gene Expression Resource

chen, z.; Luo, Z.; Zhang, D.; Li, H.; Liu, X.; Zhu, K.; Zhang, H.; Wang, Z.; Zhou, P.; Ren, J.; Zhao, A.; Zuo, Z.

10.1101/2022.04.10.487568 — bioinformatics — Posted on 2022-04-10

2487 Droplet array-based platform for parallel optical analysis of dynamic extracellular vesicle secretion from single cells

Hattori, K.; Goda, Y.; Yamashita, M.; Yoshioka, Y.; Kojima, R.; Ota, S.

10.1101/2022.04.07.487410 — bioengineering — Posted on 2022-04-10

2488 An oligogenic inheritance test detects risk genes and their interactions in congenital heart defects and developmental comorbidities

Pittman, M.; Lee, K.; Srivastava, D.; Pollard, K. S.

10.1101/2022.04.08.487704 — genetics — Posted on 2022-04-10

2489 Evolution of selfish multicellularity: collective organisation of individual spatio-temporal regulatory strategies

Vroomans, R. M.; Colizzi, E. S.

10.1101/2022.04.08.487695 — evolutionary biology — Posted on 2022-04-10

2490 Evolutionary history mediates population response to rapid environmental change through within-generational and transgenerational plasticity

Clement, D. T.; Neylan, I. P.; Roberts, N. J.; Schreiber, S. T.; Trimmer, P. C.; Sih, A.

10.1101/2022.04.08.487713 — evolutionary biology — Posted on 2022-04-10

2491 Multiple mating rescues offspring sex ratio but not productivity in a haplodiploid exposed to developmental heat stress

Costa, S.; Magalhaes, S.; Rodrigues, L. R.

10.1101/2022.04.07.487407 — evolutionary biology — Posted on 2022-04-10

2492 Diversity and evolution of telomere and subtelomere DNA sequences in insects

Lukhtanov, V. A.

10.1101/2022.04.08.487650 — evolutionary biology — Posted on 2022-04-10

2493 On the evolutionary trade-off between growth anddispersal during a range expansion

Zamberletti, P.; Roques, L.; Lavigne, F.; Papaïx, J.

10.1101/2022.04.07.487471 — evolutionary biology — Posted on 2022-04-10

2494 Molecular mechanisms of microbiome modulation by the diatom secondary metabolite azelaic acid

Shibl, A. A.; Ochsenkuhn, M. A.; Mohamed, A. R.; Coe, L.; Yun, Y.; Amin, S. A.

10.1101/2022.04.08.487398 — ecology — Posted on 2022-04-10

2495 Growth limitation via chemically complex carbohydrates reduces sensitivity of synthetic human gut communities to perturbations

Loss, E. O.; Thompson, J.; Cheung, K. P.; Qian, Y.; Venturelli, O. S.

10.1101/2022.04.08.487701 — ecology — Posted on 2022-04-10

2496 Drought selection on Arabidopsis populations and their microbiomes

Karasov, T.; Neumann, M.; Shirsekar, G.; Monroe, G.; Weigel, D.; Schwab, R.

10.1101/2022.04.08.487684 — ecology — Posted on 2022-04-10

2497 Pelagic seabirds reduce risk by flying into the eye of the storm

Lempidakis, E.; Shepard, E. L. C.; Ross, A. N.; Matsumoto, S.; Koyama, S.; Takeuchi, I.; Yoda, K.

10.1101/2022.04.07.487409 — ecology — Posted on 2022-04-10

2498 Heterogeneity in the size of the apical surface of cortical progenitors

Badouel, C.; Audouard, C.; Davy, A.

10.1101/2022.04.10.487608 — developmental biology — Posted on 2022-04-10

2499 WDR47 facilitates cell-specific ciliogenesis by modulating intraflagellar transport

Song, C.; Zeng, X.; Zeng, W.; Tong, X.; Li, Q.

10.1101/2022.04.10.487758 — developmental biology — Posted on 2022-04-10

2500 CCDC66 regulates primary cilium length and signaling competence via multi-site interactions with transition zone and axonemal proteins

Conkar, D.; Odabasi, E.; Deretic, J.; Batman, U.; Frikstad, K.-A. M.; Patzke, S.; Firat-Karalar, E. N.

10.1101/2022.04.10.487777 — cell biology — Posted on 2022-04-10

2501 Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

Johnson, N. M.; Parham, L. R.; Na, J.; Monaghan, K. E.; Kolev, H. M.; Klochkova, A.; Kim, M. S.; Danan, C. H.; Cramer, Z.; Simon, L. A.; Naughton, K. E.; Adams-Tzivelekidis, S.; Tian, Y.; Williams, P. A.; Leu, N. A.; Sidoli, S.; Whelan, K. A.; Li, N.; Lengner, C. J.; Hamilton, K. E.

10.1101/2022.04.08.487404 — cell biology — Posted on 2022-04-10

2502 Multishot Tomography for High-Resolution In Situ Subtomogram Averaging.

Khavnekar, S.; Wan, W.; Majumder, P.; Wietrzynski, W. S.; Erdmann, P. S.; Plitzko, J. M.

10.1101/2022.04.10.487763 — molecular biology — Posted on 2022-04-10

2503 Bile acid-CoA:amino acid N-acyltransferase gene knockout alters early life development, the gut microbiome and reveals unusual bile acid conjugates in mice

Neugebauer, K. A.; Guzior, D. V.; Feiner, J.; Rzepka, M.; Schillmiller, A.; O'Reilly, S.; Jones, A. D.; Watson, V. E.; Luyendyk, J. P.; McCabe, L.; Quinn, R. A.

10.1101/2022.04.10.487642 — microbiology — Posted on 2022-04-10

2504 Photodynamic inactivation of pathogenic bacteria on human skin by applying a potent photosensitizer in a hydrogel

Eckl, D. B.; Hoffmann, A. K.; Landgraf, N.; Kalb, L.; Baessler, P.; Wallner, S.; Eichner, A.; Huber, H.; Baeumler, W.

10.1101/2022.04.10.487760 — microbiology — Posted on 2022-04-10

2505 Alleviation of salt stress in winter wheat by Pantoea spp. endophytes isolated from spontaneous desert plants of the Sahara

Belaouni, H. A.; Bendaha, M. E. A.; Benattia, H.; Medouh, M.; Berini, K.; Ahmed, S. B.; Zitouni, A.

10.1101/2022.04.10.487791 — microbiology — Posted on 2022-04-10

2506 T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

Bazioti, V.; La Rose, A. M.; Maassen, S.; Bianchi, F.; de Boer, R.; Halmos, B.; Dabral, D.; Guilbaud, E.; Svendsen, A. F.; Groenen, A. G.; Marmolejo-Garza, A.; Koster, M. H.; Kloosterhuis, N. J.; Havinga, R.; Pranger, A. T.; Langelaar-Makkinje, M.; de Bruin, A.; van de Sluis, B.; Kohan, A. B.; Yvan-Charvet, L.; van den Bogaart, G.; Westerterp, M.

10.1101/2022.04.10.487770 — immunology — Posted on 2022-04-10

2507 ERPs responses to dominance features from human faces

Miao, C.; Li, X.; Derrington, E.; Li, Y.; Dreher, J.-C.

10.1101/2022.04.06.487309 — neuroscience — Posted on 2022-04-10

2508 Functionally and structurally distinct fusiform face area(s) in over 1000 participants

Chen, X.; Liu, X.; Parker, B. J.; Zhen, Z.; Weiner, K. S.

10.1101/2022.04.08.487562 — neuroscience — Posted on 2022-04-10

2509 Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in GAERS and NEC rats

De Deurwaerdere, P.; Casarrubea, M.; Cassar, D.; Radic, M.; Puginier, E.; Chagraoui, A.; Crescimanno, G.; Crunelli, V.; Di Giovanni, G.

10.1101/2022.04.08.487688 — neuroscience — Posted on 2022-04-10

2510 Neuro-cognitive models of single-trial EEG measures describe latent effects of spatial attention during perceptual decision making

Ghaderi-Kangavari, A.; Amani Rad, J.; Parand, K.; Nunez, M. D.

10.1101/2022.04.07.487571 — neuroscience — Posted on 2022-04-10

2511 Dynamic rewiring of electrophysiological brain networks during learning

Ruggeri, P.; Miehlbradt, J.; Kabbara, A.; Hassan, M.

10.1101/2022.04.08.487166 — neuroscience — Posted on 2022-04-10

2512 Dissecting brain grey and white matter microstructure: a novel clinical diffusion MRI protocol

Schiavi, S.; Palombo, M.; Zaca, D.; Tazza, F.; Lapucci, C.; Castellan, L.; Costagli, M.; Inglese, M.

10.1101/2022.04.08.487640 — neuroscience — Posted on 2022-04-10

2513 Genome-wide inference reveals that feedback regulations constrain promoter-dependent transcriptional burst kinetics

Luo, S.; Wang, Z.; Zhang, Z.; Zhou, T.; Zhang, J.

10.1101/2022.04.08.487618 — systems biology — Posted on 2022-04-10

2514 Dispersion and Plant Arrangement Condition the Timing and Magnitude of Coffee Rust Infection

Van Cauwelaert, E. M.; Gonzalez, C. G.; Boyer, D.; Hajian-Forooshani, Z.; Vandermeer, J.; Benitez, M.

10.1101/2022.04.07.487552 — systems biology — Posted on 2022-04-10

2515 Molecular signatures of proteostasis control in motor neurons with different sensitivity to Amyotrophic Lateral Sclerosis

Maity, S.; Fiore, A. Z.; Iannitelli, D. E.; Disi, A.; Rendleman, J.; Espiritu, J.; Paradise, V.; Ramachandran, K.; Mazzoni, E. O.; Vogel, C.

10.1101/2022.04.10.487765 — systems biology — Posted on 2022-04-10

2516 Learning inverse folding from millions of predicted structures

Hsu, C.; Verkuil, R.; Liu, J.; Lin, Z.; Hie, B.; Sercu, T.; Lerer, A.; Rives, A.

10.1101/2022.04.10.487779 — systems biology — Posted on 2022-04-10

2517 Manipulating the 3D organization of the largest synthetic yeast chromosome

Zhang, W.; Stefanita, L. L.; Yamashita, H.; Shen, M. J.; Mitchell, L. A.; Kurasawa, H.; Haase, M. A. B.; Sun, X.; Jiang, Q.; Lauer, S. L.; McCulloch, L. H.; Zhao, Y.; Ichikawa, D.; Easo, N.; Lin, S. J.; Fanfani, V.; Camellato, B. R.; Zhu, Y.; Cai, J.; Xu, Z.; Sacasa, M.; Accardo, R.; Ahn, J. Y.; Annadanam, S.; Brammer Basta, L. A.; Bello, N.; Cai, L.; Cerritos, S.; Cornwell, M.; D'Amato, A.; Hacker, M.; Hersey, K.; Kennedy, E.; Kianercy, A.; Kim, D.; Lim, H. S.; McCutcheon, G.; McGirr, K.; Meaney, N.; Meyer, L.; Moyer, A.; Nimer, M.; Sabbatini, C.; Scheifele, L.; Shores, L.; Silvestrone, C.; S

10.1101/2022.04.09.487066 — synthetic biology — Posted on 2022-04-10

2518 Additive and Dominant Loci Jointly Pyramiding the Grain Quality of Hybrid Rice

Li, L.; Zheng, X.; Wang, J.; Zhang, X.; He, X.; Xiong, L.; Song, S.; Su, J.; Tang, W.; Diao, Y.; Yuan, Z.; Zhang, Z.; Hu, Z.

10.1101/2022.04.09.487438 — plant biology — Posted on 2022-04-10

2519 Improvement of Gene Delivery and Mutation Efficiency in the CRISPR-Cas9 Wheat (Triticum aestivum L.) Genomics System via Biolistics

Tanaka, J.; Minkenberg, B.; Poddar, S.; Staskawicz, B.; Cho, M.-J.

10.1101/2022.04.09.487748 — plant biology — Posted on 2022-04-10

2520 Type One Protein Phosphatase Regulates Fixed-Carbon Starvation-Induced Autophagy by Dephosphorylating ATG13a to Facilitate ATG1a-ATG13a Formation in Arabidopsis

Wang, Q.; Hou, S.

10.1101/2022.04.10.487768 — plant biology — Posted on 2022-04-10

2521 Integrated Systems-Level Proteomics and Metabolomics Reveals the Diel Molecular Landscape of Diverse Kale Cultivars

Scandola, S.; Mehta, D.; Castillo, B.; Boyce, N.; Uhrig, R. G.

10.1101/2022.04.09.487754 — plant biology — Posted on 2022-04-10

2522 Nicotine measurement on Cambridge Filter PADs: an interlaboratory comparison to evaluate exposure by different electronic devices and traditional cigarette

Zuccarello, P.; Emma, R.; Caruso, M.; Pulvirenti, R.; Rust, S.; Poulas, K.; Zadjali, F.; Boffo, S.; Volarevic, V.; Lesmana, R.; Abdulkhakov, S. R.; Mesiakaris, K.; Tobi, M. A.; Giordano, A.; Arsenijevic, A.; Barliana, M. I.; Kitaeva, K. V.; Polosa, R.; Li Volti, G.; Ferrante, M.

10.1101/2022.04.07.487344 — pharmacology and toxicology — Posted on 2022-04-10

2523 Comparative analysis of high- and low-level deep learning approaches in microsatellite instability prediction

Park, J.; Chung, Y. R.; Nose, A.

10.1101/2022.04.09.487718 — pathology — Posted on 2022-04-10

2524 Protein kinase C alpha is a central node for tumorigenic transcriptional networks in human prostate cancer

Cooke, M.; Zhang, X.; Zhang, S.; Lal, P.; Daniel, R. E.; Feldman, M. D.; Abba, M. C.; Kazanietz, M. G.

10.1101/2022.04.08.487680 — cancer biology — Posted on 2022-04-10

2525 A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer

Kelly, M. R.; Wisniewska, K.; Regner, M. J.; Lewis, M. W.; Perreault, A. A.; Davis, E. S.; Phanstiel, D. H.; Parker, J. S.; Franco, H. L.

10.1101/2022.04.08.487699 — cancer biology — Posted on 2022-04-10

2526 Targeting N-Myc in Neuroblastoma with Selective Aurora Kinase A Degraders

Tang, J.; Moorthy, R.; Demir, O.; Baker, Z. D.; Naumann, J. A.; Jones, K. F. M.; Grillo, M. J.; Haefner, E. S.; Shi, K.; Levy, M. J.; Aihara, H.; Harris, R. S.; Amaro, R. E.; Levinson, N. M.; Harki, D. A.

10.1101/2022.04.09.487756 — cancer biology — Posted on 2022-04-10

2527 Acquired resistance to anti-PD1 therapy in patients with NSCLC reveals changes in T cell phenotypes and MET amplification

Hiltbrunner, S.; Cords, L.; Kasser, S.; Freiberger, S. N.; Kreutzer, S.; Toussaint, N. C.; Grob, L.; Opitz, I.; Messerli, M.; Zoche, M.; Soltermann, A.; Rechsteiner, M.; van den Broek, M.; Bodenmiller, B.; Curioni-Fontecedro, A.

10.1101/2022.04.08.487590 — cancer biology — Posted on 2022-04-10

2528 Pan-cancer quantification of neoantigen-mediated immunoediting in cancer evolution

Wu, T.; Wang, G.; Wang, X.; Wang, S.; Zhao, X.; Wu, C.; Ning, W.; Tao, Z.; Chen, F.; Liu, X.-S.

10.1101/2022.04.08.487711 — cancer biology — Posted on 2022-04-10

2529 Experimental evolution in TP53 deficient gastric organoids recapitulates tumorigenesis

10.1101/2022.04.09.487529 — cancer biology — Posted on 2022-04-10

2530 Structure and ensemble refinement against SAXS data: combining MD simulations with Bayesian inference or with the maximum entropy principle

Chatzimagas, L.; Hub, J. S.

10.1101/2022.04.05.487171 — biophysics — Posted on 2022-04-10

2531 Quantum chemical elucidation of a sevenfold symmetric bacterial antenna complex

Cupellini, L.; Qian, P.; Nguyen-Phan, C. T.; Gardiner, A. T.; Cogdell, R. J.

10.1101/2022.04.09.487728 — biophysics — Posted on 2022-04-10

2532 SIQ: easy quantitative measurement of mutation profiles in sequencing data

van Schendel, R.; Schimmel, J.; Tijsterman, M.

10.1101/2022.04.08.487585 — bioinformatics — Posted on 2022-04-10

2533 Kinome Inhibition States and Multiomics Data Enable Prediction of Cell Viability in Diverse Cancer Types

Berginski, M.; Joisa, C. U.; Golitz, B.; Gomez, S. M.

10.1101/2022.04.08.487646 — bioinformatics — Posted on 2022-04-10

2534 Subtractive proteomics analysis to uncover the potent drug targets for distinctive drug design of Candida auris

Bappy, M. N. I.; Robin, T. B.; Prome, A. A.; Laskar, F. S.; Roy, A.; Akter, H.; Zinnah, K. M. A.

10.1101/2022.04.07.487516 — bioinformatics — Posted on 2022-04-10

2535 NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data

Bahl, E.; Chatterjee, S.; Elsadany, M.; Vanrobaeys, Y.; Lin, L.-C.; Giese, K. P.; Abel, T.; Michaelson, J.

10.1101/2022.04.08.487573 — bioinformatics — Posted on 2022-04-10

2536 Multi-Head Attention-based U-Nets for Predicting Protein Domain Boundaries Using 1D Sequence Features and 2D Distance Maps

Mahmud, S.; Guo, Z.; Quadir, F.; Liu, J.; Cheng, J.

10.1101/2022.04.08.487689 — bioinformatics — Posted on 2022-04-10

2537 MOCCS profile analysis clarifies the cell type dependency of transcription factor-binding sequences and cis-regulatory SNPs in humans

Tahara, S.; Tsuchiya, T.; Matsumoto, H.; Ozaki, H.

10.1101/2022.04.08.487641 — bioinformatics — Posted on 2022-04-10

2538 Recovery of 447 Eukaryotic bins reveals major challenges for Eukaryote genome reconstruction from metagenomes.

Saraiva, J. P.; Bartholomaus, A.; Toscan, R.; Baldrian, P.; Nunes da Rocha, U.

10.1101/2022.04.07.487146 — bioinformatics — Posted on 2022-04-10

2539 Functional feature selection reveals the inner cell mass in human pre-implantation embryo single cell RNA sequencing data

Radley, A.; Smith, A.; Dunn, S.-J.

10.1101/2022.04.08.487653 — bioinformatics — Posted on 2022-04-10

2540 Data Driven Control of Vagus Nerve Stimulation for the Cardiac System

Branen, A.; Yao, Y.; Kothare, M.; Mahmoudi, B.; Kumar, G.

10.1101/2022.04.08.487633 — bioengineering — Posted on 2022-04-10

2541 Simulating the Tumor Microenvironment for Immune Cell Interactions via Deployable Extrusion Bioprinting

Mazzaglia, C.; Sheng, Y.; Rodrigues, L. N.; Lei, I. M.; Shields, J.; Huang, Y. Y. S.

10.1101/2022.04.08.487692 — bioengineering — Posted on 2022-04-10

2542 Design of a Minimal di-Nickel Hydrogenase Peptide

Mancini, J. A.; Pike, D. H.; Poudel, S.; Timm, J.; Tyryshkin, A. M.; Siess, J.; Molinaro, P.; McCann, J. J.; Waldie, K. M.; Koder, R. L.; Falkowski, P. G.; Nanda, V.

10.1101/2022.04.09.487740 — biochemistry — Posted on 2022-04-10

2543 Production of adaptive movement patterns via an insect inspired Spiking Neural Network Central Pattern Generator.

Steinbeck, F.; Nowotny, T.; Philippides, A.; Graham, P.

10.1101/2022.04.07.487574 — animal behavior and cognition — Posted on 2022-04-10

2544 Life-long Dietary Restrictions have Negligible or Damaging Effects on Late-life Cognitive Performance: A Key Role for Genetics in Outcomes

Ouellette, A. R.; Hadad, N.; Deighan, A.; Robinson, L.; O'Connell, K. M. S.; Freund, A.; Churchill, G. A.; Kaczorowski, C.

10.1101/2022.04.09.487742 — animal behavior and cognition — Posted on 2022-04-10

2545 A novel lineage of the Capra genus discovered in the Taurus Mountains of Turkey using ancient genomics.

Daly, K. G.; Arbuckle, B. S.; Rossi, C.; Mattiangeli, V.; Lawlor, P. A.; Mashkour, M.; Sauer, E.; Lesur, J.; Atici, L.; Erek, C. M.; Bradley, D. G.

10.1101/2022.04.08.487619 — genomics — Posted on 2022-04-10

2546 High quality genomes corroborate 29 chromosomes of the haploid Hyles (Lepidoptera: Sphingidae) karyotype

Hundsdoerfer, A. K.; Schell, T.; Patzold, F.; Yoshido, A.; Marec, F.; Daneck, H.; Winkler, S.; Greve, C.; Hiller, M.; Pippel, M.

10.1101/2022.04.08.487644 — genomics — Posted on 2022-04-10

2547 Capped nascent RNA sequencing reveals novel therapy-responsive enhancers in prostate cancer

Cotter, K. A.; Shah, S. R.; Paramo, M. I.; Lou, S.; Yao, L.; Rubin, P. D.; Chen, Y.; Gerstein, M.; Rubin, M.; Yu, H.

10.1101/2022.04.08.487666 — genomics — Posted on 2022-04-10

2548 Population genomics unravels the Holocene history of Triticum-Aegilops species

Zhao, X.; Guo, Y.; Kang, L.; Bi, A.; Xu, D.; Zhang, Z.; Jijin, Z.; Yang, X.; Xu, J.; Xu, S.; Song, X.; Zhang, M.; Li, Y.; Kear, P.; Wang, J.; Yin, C.; Liu, Z.; Fu, X.; Lu, F.

10.1101/2022.04.07.487499 — genetics — Posted on 2022-04-10

2549 Uncovering the roles of lignin-related genes in disease resistance in maize using mutant and association analysis

Kolkman, J. M.; Moreta, D. E.; Repka, A.; Bradbury, P.; Nelson, R. J.

10.1101/2022.04.08.487682 — genetics — Posted on 2022-04-10

2550 Statistical learning for sparser fine-mapped polygenic models: the prediction of LDL-cholesterol

Maj, C.; Staerk, C.; Borisov, O.; Klinkhammer, H.; Yeung, M. W.; Krawitz, P.; Mayr, A.

10.1101/2022.04.07.487343 — genetics — Posted on 2022-04-10

2551 High-throughput Oligopaint screen identifies druggable regulators of genome folding

Park, D. S.; Nguyen, S. C.; Isenhart, R.; Shah, P. P.; Kim, W.; Barnett, R. J.; Chandra, A.; Luppino, J. M.; Harke, J.; Wai, M.; Yang, R.; Lan, Y.; Yoon, S.; Yunker, R.; Vahedi, G.; Phillips-Cremins, J. E.; Jain, R.; Joyce, E. F.

10.1101/2022.04.08.487672 — genetics — Posted on 2022-04-10

2552 TwinEQTL: Ultra Fast and Powerful Association Analysis for eQTL and GWAS in Twin Studies

Xia, K.; Zou, F.; Shabalin, A. A.; Knickmeyer, R. C.; Gilmore, J. H.; Chung, W.; Styner, M.; Sullivan, P. F.; Wright, F. A.; Yin, Z.

10.1101/2022.04.08.487703 — genetics — Posted on 2022-04-10

2553 Social determinants of health and disease in companion dogs: A cohort study from the Dog Aging Project

McCoy, B. M.; Brassington, L.; Jin, K.; Dolby, G. A.; Shrager, S.; Collins, D.; Dunbar, M.; Dog Aging Project Consortium, ; Snyder-Mackler, N.

10.1101/2022.04.08.487645 — evolutionary biology — Posted on 2022-04-10

2554 Natural and human-mediated drivers of microevolution in Neotropical palms: a historical genomics approach

Brousseau, L.; Santoni, S.; Weber, A.; Odonne, G.

10.1101/2022.04.08.486529 — evolutionary biology — Posted on 2022-04-10

2555 Salt stress alters the spectrum of de novo mutation available to selection during experimental adaptation of Chlamydomonas reinhardtii

Hasan, A. R.; Lachapelle, J.; El-Shawa, S. A.; Potjewyd, R.; Ford, S. A.; Ness, R. W.

10.1101/2022.04.08.487548 — evolutionary biology — Posted on 2022-04-10

2556 How connected are different multitrait phenotypes in a model diatom genus?

Hinners, J.; Argyle, P. A.; Walworth, N. G.; Doblin, M. A.; Levine, N. M.; Collins, S.

10.1101/2022.04.08.487611 — evolutionary biology — Posted on 2022-04-10

2557 DecentTree: Scalable Neighbour-Joining for the Genomic Era

Wang, W.; Barbetti, J.; Wong, T.; Thornlow, B.; Corbett-Detig, R.; Turakhia, Y.; Lanfear, R.; Minh, B. Q.

10.1101/2022.04.10.487712 — evolutionary biology — Posted on 2022-04-10

2558 Haul-out behavior and aerial survey detectability of seals in the Bering and Chukchi seas

London, J. M.; Conn, P. B.; Hardy, S. K.; Richmond, E. L.; Ver Hoef, J. M.; Cameron, M. F.; Crawford, J. A.; Von Duyke, A. L.; Quakenbush, L. T.; Boveng, P. L.

10.1101/2022.04.07.487572 — ecology — Posted on 2022-04-10

2559 Temperature and resources interact to shape phytoplankton size-abundance relationships at a continental scale

Gjoni, V.; Glazier, D. S.; Ibelings, B. W.; Thomas, M. K.

10.1101/2022.04.09.487731 — ecology — Posted on 2022-04-10

2560 Human Platelet Lysate as Alternative of Fetal Bovine Serum for Enhanced Human in vitro Bone Resorption and Remodeling

de Wildt, B. W. M.; Ito, K.; Hofmann, S.

10.1101/2022.04.07.487531 — immunology — Posted on 2022-04-10

2561 Humans have distinct repertoires of IgA1

Dingess, K.; Hoek, M.; van Rijswijck, D.; Tamara, S.; den Boer, M. A.; Damen, M.; Barendregt, A.; Romijn, M.; Juncker, H. G.; van Keulen, B. J.; Vidarsson, G.; van Goudoever, J.; Bondt, A.; Heck, A. J. R.

10.1101/2022.04.08.487627 — immunology — Posted on 2022-04-10

2562 Mathematical Modeling of Rhesus Cytomegalovirus (RhCMV) Placental Transmission in Seronegative Rhesus Macaques

Gong, Y.; Mostrom, M.; Otero, C.; Valencia, S.; Kaur, A.; Permar, S.; Chan, C.

10.1101/2022.04.07.487583 — immunology — Posted on 2022-04-10

2563 Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS injury and viral infection

Ayasoufi, K.; Wolf, D. M.; Namen, S. L.; Tritz, Z. P.; Jin, F.; Pfaller, C. K.; Goddery, E. N.; Fain, C. E.; Gulbicki, L. R.; Khadka, R. H.; Yokanovich, L. T.; Hansen, M. J.; Johnson, A. J.

10.1101/2022.04.08.487707 — immunology — Posted on 2022-04-10

2564 Mechanisms of human dynamic object recognition revealed by sequential deep neural networks

Sörensen, L. K. A.; Bohte, S. M.; De Jong, D.; Slagter, H. A.; Scholte, H. S.

10.1101/2022.04.06.487259 — neuroscience — Posted on 2022-04-10

2565 Flexible Intentions in the Posterior Parietal Cortex: An Active Inference Theory

Priorelli, M.; Stoianov, I. P.

10.1101/2022.04.08.487597 — neuroscience — Posted on 2022-04-10

2566 Genetically defined nucleus incertus neurons differ in connectivity and function

Spikol, E. D.; Cheng, J.; Macurak, M.; Subedi, A.; Halpern, M. E.

10.1101/2022.04.07.487414 — neuroscience — Posted on 2022-04-10

2567 Visuomotor mismatch responses as a hallmark of explaining away in causal inference

Mikulasch, F. A.; Rudelt, L.; Priesemann, V.

10.1101/2022.04.07.486697 — neuroscience — Posted on 2022-04-10

2568 Hippocampal hypothyroidism in mice promotes glial cell activation and spatial memory deficits.

Chamas, L.; Seugnet, I.; Poirier, R.; Clerget-Froidevaux, M.-S.; Enderlin, V.

10.1101/2022.04.06.487389 — neuroscience — Posted on 2022-04-10

2569 Unmasking hidden changes in intrinsic properties in neurons that coordinate oscillatory networks

Schneider, A. C.; Smarandache-Wellmann, C. R.

10.1101/2022.04.07.487473 — neuroscience — Posted on 2022-04-10

2570 Beyond control: experimental control protocol slightly affects prepubescent mice behavior in a sex-specific manner

Moraes, M. A.; Arabe, L. B.; Resende, B. L.; Codo, B. C.; Reis, A. L. A. L.; Souza, B. R.

10.1101/2022.04.06.487373 — neuroscience — Posted on 2022-04-10

2571 On demand nanoliter sampling probe for collection of brain fluid

Teixidor, J.; Novello, S.; Ortiz, D.; Menin, L.; Lashuel, H.; Bertsch, A.; Renaud, P.

10.1101/2022.04.08.487549 — neuroscience — Posted on 2022-04-10

2572 Brain-wide sensory aberrations in a Parkinson's Disease mouse model revealed by functional MRI

Lungu, R.; Fernandes, F. F.; Outeiro, T. F.; Shemesh, N.

10.1101/2022.04.06.487227 — neuroscience — Posted on 2022-04-10

2573 Recalibrating vision-for-action requires years after sight restoration from congenital blindness

Senna, I.; Piller, S.; Ben-Zion, I.; Ernst, M.

10.1101/2022.04.06.487358 — neuroscience — Posted on 2022-04-10

2574 Quantitative MRI maps of human neocortex explored using cell type-specific gene expression analysis

Edwards, L. J.; McColgan, P.; Helbling, S.; Zarkali, A.; Vaculciakova, L.; Pine, K. J.; Dick, F.; Weiskopf, N.

10.1101/2022.04.07.487457 — neuroscience — Posted on 2022-04-10

2575 The molecular mechanism and physiological role of silent nociceptor activation

Nees, T. A.; Wang, N.; Adamek, P.; Verkest, C.; Schaefer, I.; Virnich, J.; Balkaya, S.; Prato, V.; Morelli, C.; Zeitzschel, N.; Begay, V.; Lee, Y. J.; Lewin, G. R.; Heppenstall, P. A.; Taberner, F. J.; Lechner, S. G.

10.1101/2022.04.07.486730 — neuroscience — Posted on 2022-04-10

2576 mulEEG: A Multi-View Representation Learning on EEG Signals

Reddy, L.; Kumar, V.; Sharma, S. K.; Dadi, K.; Yarra, C.; Raju, S. B.; Rajendran, S.

10.1101/2022.04.07.487475 — neuroscience — Posted on 2022-04-10

2577 Can neurogenesis act as a neural regularizer?

Tran, L. M.; Santoro, A.; Liu, L.; Josselyn, S. A.; Richards, B.; Frankland, P. W.

10.1101/2022.04.07.487582 — neuroscience — Posted on 2022-04-10

2578 Multi-modal deep neural decoding of visual object representation in humans

Watanabe, N.; Miyoshi, K.; Jimura, K.; Shimane, D.; Keerativittayayut, R.; Nakahara, K.; Takeda, M.

10.1101/2022.04.06.487262 — neuroscience — Posted on 2022-04-10

2579 The PAICE Suite Reveals Circadian Post-Transcriptional Timing of Non-Coding RNAs and Spliceosome Components in Mus musculus Macrophages

Buel, S. M.; Debopadhaya, S.; De Los Santos, H.; Edwards, K. M.; David, A. M.; Dao, U. H.; Bennett, K. P.; Hurley, J. M.

10.1101/2022.04.08.487694 — systems biology — Posted on 2022-04-10

2580 Liver-secreted fluorescent blood plasma markers enable chronic imaging of microcirculation

Wang, X.; Delle, C.; Asiminas, A.; Akther, S.; Vittani, M.; Brogger, P.; Kusk, P.; Vo, C. T.; Konno, A.; Hirai, H.; Fukuda, M.; Weikop, P.; Goldman, S. A.; Nedergaard, M.; Hirase, H.

10.1101/2022.04.08.487498 — physiology — Posted on 2022-04-10

2581 A six-months, long acting, one-shot injectable formulation of Ivermectin as a complementary malaria vector control tool to target zoophagic Anopheles : laboratory and model-based proofs of concept.

Pooda, S. H.; Moiroux, N.; Porciani, A.; Courgeault, A.-L.; Roberge, C.; Gaudriault, G.; Sidibe, I.; Belem, A. M. G.; Rayaisse, J.-B.; Dabire, R. K.; Mouline, K.

10.1101/2022.04.07.486556 — pharmacology and toxicology — Posted on 2022-04-10

2582 The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration

Chen, P.; Li, Y.; Xu, F.; Zhang, Z.; Zuo, T.; Guo, J.; Li, K.; Liu, S.; Li, S.; Yin, J.; Chang, L.; Predrag, K.; Liddell, M.; Liz, T.; Carmichael, P.; Peng, S.; Li, J.; Zhang, Q.; Xu, P.

10.1101/2022.04.07.487458 — pharmacology and toxicology — Posted on 2022-04-10

2583 Genome-wide analysis reveals PhoP regulates pathogenicity in Riemerella anatipestifer

Zhang, Y.; Wang, Y.; Zhang, Y.; Jia, X.; Li, C.; Zhou, Z.; Hu, S.; Li, Z.

10.1101/2022.04.07.487584 — pathology — Posted on 2022-04-10

2584 Targeting RNA:Protein Interactions with an Integrative Approach Leads tothe Identification of Potent YB-1 Inhibitors

El Hage, K.; Babault, N.; Maciejak, O.; Desforges, B.; Craveur, P.; Steiner, E.; Rengifo-Gonzalez, J. C.; Henri, H.; Clement, M.-J.; Joshi, V.; Bouhss, A.; Wang, L.; Bauvais, C.; Pastre, D.

10.1101/2022.04.08.487452 — biophysics — Posted on 2022-04-10

2585 AURTHO: autoregulation as facilitator of cis-acting element discovery of orthologous transcription factors

Anderssen, S.; Naome, A.; Jadot, C.; Brans, A.; Tocquin, P.; Rigali, S.

10.1101/2022.04.06.487287 — bioinformatics — Posted on 2022-04-10

2586 Genomic analyses identify key molecules and significant biological processes in LOC441461 treated gastric cancer cells

Zhang, L.; Chang, T.; Wang, M.

10.1101/2022.04.06.487336 — bioinformatics — Posted on 2022-04-10

2587 FollicleFinder: automated three-dimensional segmentation of human ovarian follicles

Yamauchi, K. A.; Biniasch, M.; Franz, L.; Gomez, H.; De Geyter, C.; Iber, D.

10.1101/2022.04.08.487638 — bioinformatics — Posted on 2022-04-10

2588 Markov chains improve the significance computation of overlapping genome annotations

Gafurov, A.; Brejova, B.; Medvedev, P.

10.1101/2022.04.07.487119 — bioinformatics — Posted on 2022-04-10

2589 Experimental identification of individual insect visual tracking delays in free flight and their effects on visual swarm patterns

Islam, M. S.; Faruque, I. A.

10.1101/2022.04.06.487367 — bioengineering — Posted on 2022-04-10

2590 Immobilised enzyme cascade for targeted glycosylation

Makrydaki, E.; Donini, R.; Krueger, A.; Royle, K. E.; Moya Ramirez, I.; Kuntz, D. A.; Rose, D. R.; Haslam, S. M.; Polizzi, K. M.; Kontoravdi, C.

10.1101/2022.04.08.487553 — bioengineering — Posted on 2022-04-10

2591 RetroSnake: a Modular End-to-End Pipeline for Detection of Human Endogenous Retrovirus (HERV) Transposable Elements in Next Generation Sequencing (NGS) Data

Kabiljo, R.; Bowles, H.; Marriott, H.; Jones, A. R.; Dobson, R. J.; Quinn, J. P.; Swanson, C. M.; Al Chalabi, A.; Iacoangeli, A.

10.1101/2022.04.08.487607 — genomics — Posted on 2022-04-10

2592 The GUN mutants: new weapons to unravel ascospore germination regulation in the model fungus Podospora anserina

Demoor, A.; Lacaze, I.; Ferrari, R.; Lalanne, C.; Silar, P.; Brun, S.

10.1101/2022.04.08.487612 — genetics — Posted on 2022-04-10

2593 The important choice of reference environment in microevolutionary climate response predictions

Ergon, R.

10.1101/2022.01.07.475361 — evolutionary biology — Posted on 2022-04-10

2594 Genome structures resolve the early diversification of teleost fishes

Parey, E.; Louis, A.; Montfort, J.; Bouchez, O.; Roques, C.; Iampietro, C.; Lluch, J.; Castinel, A.; Donnadieu, C.; Desvignes, T.; Bucao, C. F.; Jouanno, E.; Wen, M.; Mejri, S.; Dirks, R. P.; Jansen, H. J.; Henkel, C. V.; Chen, W.-J.; Zahm, M.; Cabau, C.; Klopp, C.; Thompson, A. W.; Robinson-Rechavi, M.; Braasch, I.; Lecointre, G.; Bobe, J.; Postlethwait, J. H.; Berthelot, C.; Roest Crollius, H.; Guiguen, Y.

10.1101/2022.04.07.487469 — evolutionary biology — Posted on 2022-04-10

2595 The effects of environmental heterogeneity within cities on the evolution of clines

Santangelo, J. S.; Roux, C.; Johnson, M.

10.1101/2022.04.06.487365 — evolutionary biology — Posted on 2022-04-10

2596 Global disparity of research allocation and the Aichi biodiversity conservation targets

Mugerwa, B.; Niedballa, J.; Planillo, A.; Sheil, D.; Kramer-Schadt, S.; Wilting, A.

10.1101/2022.04.07.486958 — ecology — Posted on 2022-04-10

2597 Barcoding and its application for visualizing ecological dynamics

Agarwal, V.; Mouw, C. B.

10.1101/2022.04.07.487508 — ecology — Posted on 2022-04-10

2598 A subtype of melanopsin ganglion cells encodes ground luminance

Berry, M. H.; Moldavan, M.; Garrett, T.; Meadows, M.; Cravetchi, O.; White, E.; von Gersdorff, H.; Wright, K. M.; Allen, C.; Sivyer, B. M.

10.1101/2022.04.06.485949 — neuroscience — Posted on 2022-04-10

2599 Abstinence-dependent effects of long-access cocaine self-administration on nucleus accumbens astrocytes are observed in male, but not female rats

Kim, R.; Testen, A.; Harder, E. V.; Brown, N. E.; Witt, E. A.; Bellinger, T. J.; Franklin, J. P.; Reissner, K. J.

10.1101/2022.04.06.487393 — neuroscience — Posted on 2022-04-10

2600 Less is more - loss of EGFL7 improves memory by upregulation of VEGF-D

Schmidt, M. H.; Vasic, V.; Barth, K.; Bicker, F.; Schumann, U.; Maurer, C.; Heinig, N.; Roehlecke, C.; Nimtschke, U.; Schumann, L.; Meinhardt, M.; Mittmann, T.; Radyushkin, K.; Baumgart, J.; Tenzer, S.; Zipp, F.; Tegeder, I.

10.1101/2022.04.07.487327 — neuroscience — Posted on 2022-04-10

2601 PhenoComb: A discovery tool to assess complex phenotypes in high-dimension, single-cell datasets

Burke, P. E. P.; Strange, A.; Monk, E.; Thompson, B.; Amato, C. M.; Woods, D. M.

10.1101/2022.04.06.487335 — bioinformatics — Posted on 2022-04-10

2602 Mitotic checkpoint gene expression is tuned by coding sequences

Esposito, E.; Weidemann, D. E.; Rogers, J. M.; Morton, C. M.; Baybay, E. K. D.; Chen, J.; Hauf, S.

10.1101/2021.04.30.442180 — cell biology — Posted on 2022-04-10

2603 Hairy root transformation system as a tool for CRISPR/Cas9-directed genome editing in oilseed rape (Brassica napus)

Jedlickova, V.; Macova, K.; Stefkova, M.; Butula, J.; Stavenikova, J.; Sedlacek, M.; Robert, H. S.

10.1101/2022.04.07.487540 — plant biology — Posted on 2022-04-10

2604 Increased susceptibility to Chrysanthemum Yellows phytoplasma infection in Atcals7 ko plants is accompanied by enhanced expression of carbohydrate transporters.

Bernardini, C.; Santi, S.; Mian, G.; Levy, A.; Buoso, S.; Suh, J.-H.; Wang, Y.; Vincent, C.; van Bel, A.; Musetti, R.

10.1101/2021.06.25.449948 — plant biology — Posted on 2022-04-10

2605 Circular RNA's competing endogenous gene pair as motif in serous ovarian cancer

Cheng, L.; Zheng, X.; Leung, K.-S.; Wong, M.-H.

10.1101/2022.04.04.486923 — bioinformatics — Posted on 2022-04-10

2606 Validity of freehand three-dimensional ultrasound system in measurement of three-dimensional surface shape of shoulder muscles

Umehara, J.; Fukuda, N.; Konda, S.; Hirashima, M.

10.1101/2021.11.18.468912 — bioengineering — Posted on 2022-04-10

2607 Architecture of the chikungunya virus replication organelle

Laurent, T.; Kumar, P.; Liese, S.; Zare, F.; Jonasson, M.; Carlson, A.; Carlson, L.-A.

10.1101/2022.04.05.487153 — biophysics — Posted on 2022-04-10

2608 Use of a novel knock-in allele of Pkd1 identifies nicotinamide nucleotide dehydrogenase as a mitochondrial binding partner of polycystin-1

Lin, C.-C.; Menezes, L. F.; Pearson, E.; Zhou, F.; Ishimoto, Y.; Anderson, D. E.; Germino, G.

10.1101/2022.04.08.487705 — genetics — Posted on 2022-04-10

2609 Arousal elevation drives the development of oscillatory vocal output

Zhang, Y. S.; Alvarez, J. L.; Ghazanfar, A. A.

10.1101/2021.12.13.472498 — neuroscience — Posted on 2022-04-10

2610 Neuronal HLH-30/TFEB modulates muscle mitochondrial fragmentation to improve thermoresistance in C. elegans

Wong, S. Q.; Ryan, C. J.; Lapierre, L. R.

10.1101/2022.04.07.487519 — genetics — Posted on 2022-04-10

2611 Multilevel selection analysis reveals diversity in selfish mitochondrial genome dynamics

Gitschlag, B. L.; Patel, M. R.

10.1101/2022.04.08.487647 — evolutionary biology — Posted on 2022-04-10

2612 Mouse brain-wide transgene expression by systemic injection of genetically engineered exosomes: CAP-Exosomes

SIMPKINS, J. W.; CORBIN, D.; sarkar, S. N.

10.1101/2022.04.06.487362 — neuroscience — Posted on 2022-04-09

2613 Myelination-dependent mitochondria clustering and calcium buffering in parvalbumin interneuron axons

Kole, K.; Voesenek, B. J. B.; Brinia, M. E.; Petersen, N.; Kole, M. H. P.

10.1101/2022.04.07.487496 — neuroscience — Posted on 2022-04-10

2614 Scalable microbial strain inference in metagenomic data using StrainFacts

Smith, B. J.; Li, X.; Shi, Z. J.; Abate, A.; Pollard, K. S.

10.1101/2022.02.01.478746 — bioinformatics — Posted on 2022-04-09

2615 Structure of phage lambda Red-beta(177) annealase shows how it anneals DNA strands during single-strand annealing homologous DNA recombination

Newing, T. P.; Brewster, J. L.; Yu, H.; Johnston, N.; Fitschen, L. J.; Tolun, G.

10.1101/2022.04.09.487726 — biochemistry — Posted on 2022-04-09

2616 Caenorhabditis elegans MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12

Snel, B.; van den Heuvel, S.; Seidl, M. F.

10.1101/2022.04.07.487461 — evolutionary biology — Posted on 2022-04-09

2617 Plastic loss of motile cilia in the internal gills of Polypterus in response to high CO2 or terrestrial environments

Kimura, Y.; Nakamuta, N.; Nikaido, M.

10.1101/2022.04.06.487418 — evolutionary biology — Posted on 2022-04-09

2618 Autotaxin facilitates selective LPA receptor signaling

Salgado-Polo, F.; Borza, R.; Marsais, F.; Jagerschmidt, C.; Waeckel, L.; Moolenaar, W. H.; Ford, P.; Heckmann, B.; Perrakis, A.

10.1101/2022.04.09.487723 — cell biology — Posted on 2022-04-09

2619 Myeloid hypoxia-inducible factor HIF1A provides cardio-protection during ischemia and reperfusion via induction of netrin-1

Heck-Swain, K.-L.; Li, J.; Ruan, W.; Yuan, X.; Wang, Y.; Koeppen, M.; Eltzschig, H.

10.1101/2022.04.08.485755 — immunology — Posted on 2022-04-09

2620 Cataloging the potential functional diversity of Cacna1e splice variants using long-read sequencing

Bhuiyan, S. A.; Tyson, J. R.; Belmadani, M.; Sicherman, J.; Snutch, T. P.; Pavlidis, P. A.

10.1101/2022.04.06.487199 — neuroscience — Posted on 2022-04-09

2621 Ketamine and its metabolite 2R,6R-hydroxynorketamine promote ocular dominance plasticity and release TRKB from inhibitory control without changing perineuronal nets enwrapping parvalbumin interneurons

Cannarozzo, C.; Rubiolo, A.; Casarotto, P. C.; Castren, E.

10.1101/2022.04.06.487292 — neuroscience — Posted on 2022-04-09

2622 DeepParcellation: a novel deep learning method for robust brain magnetic resonance imaging parcellation in older East Asians

Lim, E.-C.; Choi, U.-S.; Choi, K. Y.; Lee, J. J.; Sung, Y.-W.; Ogawa, S.; Kim, B. C.; Lee, K. H.; Gim, J.; the Alzheimer's Disease Neuroimaging Initiative,

10.1101/2022.04.06.487283 — neuroscience — Posted on 2022-04-09

2623 Evaluation of in silico predictors on short nucleotide variants in HBA1, HBA2 and HBB associated with haemoglobinopathies

Tamana, S.; Xenophontos, M.; Minaidou, A.; Stephanou, C.; Harteveld, C. L.; Bento, C.; Traeger-Synodinos, J.; Fylaktou, I.; Yasin, N. M.; Hamid, F. S. A.; Esa, E.; Halim-Fikri, H.; Zilfalil, B. A.; Kakouri, A. C.; ClinGen Hemoglobinopathy VCEP, ; Kleanthous, M.; Kountouris, P.

10.1101/2022.04.07.484934 — bioinformatics — Posted on 2022-04-09

2624 PhenoComb: A discovery tool to assess complex phenotypes in high-dimension, single-cell datasets

Burke, P. E. P.; Strange, A.; Monk, E.; Thompson, B.; Amato, C.; Woods, D.

10.1101/2022.04.06.487335 — bioinformatics — Posted on 2022-04-09

2625 Computational Analysis of Effects of Clot Length on Acute Ischemic Stroke Recanalization under Different Cyclic Aspiration Loading Conditions

Patki, P.; Simon, S.; Manning, K. B.; Costanzo, F.

10.1101/2022.04.06.487217 — bioengineering — Posted on 2022-04-09

2626 Multi-network analysis reveals context-dependent kin relationships in wild sulphur-crested cockatoos, Cacatua galerita

Penndorf, J.; Ewart, K.; Klump, B. C.; Martin, J. M.; Aplin, L. M.

10.1101/2022.04.06.486687 — animal behavior and cognition — Posted on 2022-04-09

2627 Proteome-wide identification of amino acid substitutions deleterious for protein function

Rodriguez-Mias, R. A.; Hess, K. N.; Ruiz, B. Y.; Smith, I. R.; Barente, A. S.; Zimmerman, S. M.; Lu, Y. Y.; Noble, W. S.; Fields, S.; Villen, J.

10.1101/2022.04.06.487405 — genomics — Posted on 2022-04-09

2628 Studying meiosis in mitosis: Activating the meiosis-specific Red1-Hop1-Mek1 complex in mitotic budding yeast cells

Nivsarkar, V. N.; Chen, L.; Funk, S. K.; Weir, J. R.; Vader, G.

10.1101/2022.04.06.487319 — genetics — Posted on 2022-04-09

2629 A Novel Caenorhabditis elegans Gene Network Uncovers Mechanisms of Mitochondrial Maintenance

Moreno, A.; Taffet, A.; Tjahjono, E.; Kirienko, N. V.

10.1101/2022.04.06.487352 — genetics — Posted on 2022-04-09

2630 The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats

Munro, D.; Wang, T.; Chitre, A. S.; Polesskaya, O.; Ehsan, N.; Gao, J.; Chen, H.; Gusev, A.; Solberg Woods, L. C.; Saba, L. M.; Palmer, A. A.; Mohammadi, P.

10.1101/2022.04.07.487560 — genetics — Posted on 2022-04-09

2631 Analysis of flavonol regulator evolution in the Brassicaceae reveals MYB12, MYB111 and MYB21 duplications associated with MYB11 and MYB24 gene loss

Schilbert, H. M.; Glover, B. J.

10.1101/2022.04.06.487363 — evolutionary biology — Posted on 2022-04-09

2632 Assessing the importance of resistance, persistence and hyper-mutation for antibiotic treatment success with stochastic modelling

Witzany, C.; Regoes, R. R.; Igler, C.

10.1101/2022.04.07.487440 — evolutionary biology — Posted on 2022-04-09

2633 Hazel dormouse in managed woodland select for young, dense, and species-rich tree stands

Mortensen, R. M.; Fuller, M. F.; Dalby, L.; Berg, T. B.; Sunde, P.

10.1101/2022.04.06.487322 — ecology — Posted on 2022-04-09

2634 A macroecological perspective on genetic diversity in the human gut microbiome

Shoemaker, W. R.

10.1101/2022.04.07.487434 — ecology — Posted on 2022-04-09

2635 Platelet response to influenza vaccination reflects effects of aging

Konstorum, A.; Mohanty, S.; Zhao, Y.; Melillo, A.; Vander Wyk, B.; Nelson, A.; Tsang, S.; Blevins, T. P.; Belshe, R. B.; Chawla, D. G.; Rondina, M. T.; Montgomery, R. R.; Allore, H. G.; Kleinstein, S. H.; Shaw, A. C.

10.1101/2022.04.06.487196 — immunology — Posted on 2022-04-09

2636 Chitin oligomers directly promote lymphoid innate and adaptive immune cell activation

Cardona Gloria, Y.; Fuchs, K.; Chang, T.-H.; Engels, P.; Rusch, E.; Gouttefangeas, C.; Weber, A. N.

10.1101/2022.04.06.487356 — immunology — Posted on 2022-04-09

2637 Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina.

Le, N.; Appel, H.; Pannullo, N.; Hoang, T.; Blackshaw, S.

10.1101/2022.04.06.487191 — neuroscience — Posted on 2022-04-09

2638 Single and complex spikes relay distinct frequency-dependent circuit information in the hippocampus

Lowet, E.; Sheehan, D. J.; Mount, R. A.; Xiao, S.; Zhou, S.; Tseng, H.-a.; Gritton, H.; Shroff, S.; Kondabolu, K.; Cheung, C.; Mertz, J.; Hasselmo, M.; Han, X.

10.1101/2022.04.06.487256 — neuroscience — Posted on 2022-04-09

2639 Cbln1 directs axon targeting by corticospinal neurons specifically toward thoraco-lumbar spinal cord.

Song, J. H. T.; Ruven, C.; Patel, P.; Ding, F.; Macklis, J. D.; Sahni, V.

10.1101/2022.04.06.487184 — neuroscience — Posted on 2022-04-09

2640 Single nuclei RNAseq stratifies multiple sclerosis patients into three distinct white matter glia responses

Macnair, W.; Calini, D.; Agirre, E.; Bryois, J.; Jaekel, S.; Kukanja, P.; Stokar-Regenscheit, N.; Ott, V.; Foo, L. C.; Collin, L.; Schippling, S.; Urich, E.; Nutma, E.; Marzin, M.; Amor, S.; Magliozzi, R.; Heidari, E.; Robinson, M. D.; ffrench-Constant, C.; Castelo-Branco, G.; Williams, A.; Malhotra, D.

10.1101/2022.04.06.487263 — neuroscience — Posted on 2022-04-09

2641 Dendritic compartmentalization of input-specific integration and plasticity rules across cortical development

Yaeger, C. E.; Vardalaki, D.; Brown, N. J.; Harnett, M. T.

10.1101/2022.02.02.478840 — neuroscience — Posted on 2022-04-09

2642 Neural representation of intraoral olfactory and gustatory signals by the mediodorsal thalamus in alert rats

Fredericksen, K. E.; Samuelsen, C. L.

10.1101/2022.04.06.487193 — neuroscience — Posted on 2022-04-09

2643 The presynaptic active zone protein Bassoon as a marker for synapses between Type lll cells and afferent nerve fibers in taste buds

Ikuta, R.; Hamada, S.

10.1101/2022.04.06.487279 — neuroscience — Posted on 2022-04-09

2644 A descending interneuron with depolarized resting membrane potential controls C. elegans motor states

Meng, J.; Ahamed, T.; Yu, B.; Hung, W.; El Mouridi, S.; Leclercq-Blondel, A.; Gendrel, M.; Wang, Z.; Chen, L.; Wen, Q.; Boulin, T.; Gao, S.; Zhen, M.

10.1101/2022.04.06.487231 — neuroscience — Posted on 2022-04-09

2645 Functional recovery from tactile stimulation after perinatal cortical injury is mediated by FGF-2

Kolb, B.; Gibb, R.

10.1101/2022.04.06.487396 — neuroscience — Posted on 2022-04-09

2646 Drug combination prioritization for cancer treatment using single-cell RNA-seq based transfer learning

Osorio, D.; McGrail, D. J.; Sahni, N.; Yi, S. S.

10.1101/2022.04.06.487357 — bioinformatics — Posted on 2022-04-09

2647 Genotype error biases trio-based estimates of haplotype phase accuracy

Browning, B. L.; Browning, S. R.

10.1101/2022.04.06.487354 — bioinformatics — Posted on 2022-04-09

2648 Threshold Values for the Gini Variable Importance: A Empirical Bayes Approach

Dunne, R. A.

10.1101/2022.04.06.487300 — bioinformatics — Posted on 2022-04-09

2649 Mapping CAR T-cell design space using agent-based models

Prybutok, A. N.; Yu, J. S.; Leonard, J. N.; Bagheri, N.

10.1101/2022.04.07.487561 — bioengineering — Posted on 2022-04-09

2650 Lipidoid nanoparticles increase ATP uptake into hypoxic brain endothelial cells

Khare, P.; Conway, J. F.; Soundara Manickam, D.

10.1101/2022.04.07.487513 — bioengineering — Posted on 2022-04-09

2651 Probing Notch1-Dll4 Signaling in Regulating Osteogenic Differentiation of Human Mesenchymal Stem Cells using Single Cell Nanobiosensor

Wang, S.; Zhao, Y.; Yang, R.; Bousraou, Z.; Richardson, K.

10.1101/2022.04.07.487463 — bioengineering — Posted on 2022-04-09

2652 The intra-mitochondrial contact site formed by Cqd1 and the Por1-Om14 complex modulates architecture and morphology of mitochondria

Khosravi, S.; Chelius, X.; Unger, A.-K.; Sachsenheimer, T.; Luechtenborg, C.; Schieweck, R.; Bruegger, B.; Westermann, B.; Klecker, T.; Neupert, W.; Harner, M. E.

10.1101/2022.04.09.487722 — biochemistry — Posted on 2022-04-09

2653 Resetting H3K4me3, H3K27ac, H3K9me3 and H3K27me3 during the maternal-to-zygotic transition and blastocyst lineage specification in bovine embryos

Zhou, C.; Halstead, M. M.; Bonnet-Garnier, A.; Schultz, R. M.; ROSS, P. J.

10.1101/2022.04.07.486777 — developmental biology — Posted on 2022-04-09

2654 Bacterial produce membrane-binding small molecules to regulate horizontal gene transfer in vesicles

Boedicker, J.; Tran, F.; Gangan, M. S.

10.1101/2022.04.08.487716 — microbiology — Posted on 2022-04-09

2655 Quantitative characterization of the path of glucose diffusion facilitated by human glucose transporter 1

Chen, L. Y.

10.1101/787259 — biophysics — Posted on 2022-04-09

2656 Increased early sodium current causes familial atrial fibrillation and dampens effect of flecainide

O'Reilly, M.; Sommerfeld, L. C.; O'Shea, C.; Broadway-Stringer, S.; Andaleeb, S.; Reyat, J. S.; Kabir, S. N.; Malinova, A.; Delbue, D.; Fortmueller, L.; Gehmlich, K.; Pavlovic, D.; Skryabin, B. V.; Holmes, A. P.; Kirchhof, P.; Fabritz, L.

10.1101/2022.01.18.476646 — molecular biology — Posted on 2022-04-09

2657 Hairy root transformation system as a tool for CRISPR/Cas9-directed genome editing in oilseed rape (Brassica napus)

Jedlickova, V.; Macova, K.; Stefkova, M.; Butula, J.; StavenIkova, J.; Sedlacek, M.; Robert Boisivon, H. S.

10.1101/2022.04.07.487540 — plant biology — Posted on 2022-04-09

2658 Circadian and diel regulation of photosynthesis in the bryophyte Marchantia polymorpha

Cuitun-Coronado, D.; Rees, H.; Colmer, J.; Hall, A.; de Barros Dantas, L. L.; Dodd, A. N.

10.1101/2022.01.11.475783 — plant biology — Posted on 2022-04-09

2659 Auxin-driven ecophysiological diversification of leaves in domesticated tomato

dos Reis Moreira, J.; Rosa, B. L.; Lira, B. S.; Lima, J. E.; Souza, L. N.; Otoni, W. C.; Figueira, A.; Freschi, L.; Sakamoto, T.; Peres, L.; Rossi, M.; Zsogon, A.

10.1101/2021.12.16.473023 — plant biology — Posted on 2022-04-09

2660 Quantifying formations of Neutravidin clusters on biotinylated mixed silane Self-Assembled Monolayers.

Ghosh, U.

10.1101/2022.03.21.485091 — bioengineering — Posted on 2022-04-09

2661 Restoration of high-sensitivity patterned vision in motion with an engineered light-gated G protein-coupled receptor

Holt, A.; Berry, M.; Lo, J.; Donthamsetti, P.; Visel, M.; Broichhagen, J.; Flannery, J. G.; Isacoff, E. Y.

10.1101/2022.04.07.487476 — neuroscience — Posted on 2022-04-09

2662 The senescence regulator S40 family members from Caragana intermedia and Arabidopsis thaliana inhibit leaf senescence via promoting cytokinins synthesis

Li, G.; Yang, T.; Zhang, M.; Yang, Q.; Liu, K.; Cui, J.; Chen, J.; Ren, Y.; Shao, Y.; Wang, R.

10.1101/2022.04.08.487715 — plant biology — Posted on 2022-04-09

2663 OncoLoop: A network-based precision cancer medicine framework

Vasciaveo, A.; Zou, M.; Arriaga, J. M.; Geraldes de Almeida, F.; Douglass, E. F.; Shibata, M.; Rodriguez-Calero, A.; de Brot, S.; Mitrofanova, A.; Chua, C. W.; Karan, C.; Realubit, R.; Pampou, S. Y.; Kim, J. Y.; Corey, E.; Alvarez, M.; Rubin, M. A.; Shen, M. M.; Califano, A.; Abate-Shen, C.

10.1101/2022.02.11.479456 — cancer biology — Posted on 2022-04-09

2664 Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle

Suresh, P.; Galstyan, V.; Phillips, R.; Dumont, S.

10.1101/2022.04.08.487649 — biophysics — Posted on 2022-04-09

2665 Early urinary candidate biomarkers and clinical outcomes of intervention in a rat model of experimental autoimmune encephalomyelitis

Zhao, M.; Zhang, Y.; Wu, J.; Li, X.; Gao, Y.

10.1101/205294 — biochemistry — Posted on 2022-04-09

2666 Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection

Nahas, K. L.; Connor, V.; Scherer, K. M.; Kaminski, C. F.; Harkiolaki, M.; Crump, C. M.; Graham, S. C.

10.1101/2021.10.11.463900 — microbiology — Posted on 2022-04-09

2667 Thalamic bursting and the role of timing and synchrony in thalamocortical signaling in the awake mouse

Borden, P. Y.; Wright, N. C.; Morissette, A. R.; Jaeger, D.; Haider, B.; Stanley, G. B.

10.1101/2021.07.09.451656 — neuroscience — Posted on 2022-04-09

2668 Synergistic balance of local segregation and global integration mechanisms in large-scale brain networks underlies perceptual experience

Mukherjee, A.; Singh, S. S.; Ray, D.; Raghunathan, P.; Banerjee, A.

10.1101/2020.09.02.276071 — neuroscience — Posted on 2022-04-09

2669 Traits of soil bacteria predict plant responses to soil moisture

Bolin, L. G.; Lennon, J. T.; Lau, J. A.

10.1101/2022.04.08.487329 — ecology — Posted on 2022-04-09

2670 A baseline for the genetic stock identification of Atlantic herring, Clupea harengus, in ICES Divisions 6.a, 7.b-c

Farrell, E. D.; Andersson, L.; Bekkevold, D.; Campbell, N.; Carlsson, J.; Clarke, M. W.; Egan, A.; Folkvord, A.; Gras, M.; Maersk Lusseau, S.; Mackinson, S.; Nolan, C.; O'Connell, S.; O'Malley, M.; Pastoors, M.; Pettersson, M. E.; White, E.

10.1101/2022.04.07.487341 — zoology — Posted on 2022-04-09

2671 The multi-BRCT domain protein DDRM2 is required for homologous recombination in plants

Wang, L.; Yu, C.; Hou, L.; Huang, Y.; Cui, X.; Xu, S.; Yan, S.

10.1101/2022.04.08.487320 — plant biology — Posted on 2022-04-09

2672 Identification of YAB11-NGAL1 controlling leaf serrations through enhanced genome-wide association studies of Populus

Liu, P.; Bu, C.; Chen, P.; Zhang, D.; Song, Y.

10.1101/2022.04.07.487505 — plant biology — Posted on 2022-04-09

2673 Prioritizing Candidate eQTL Causal Genes in Arabidopsis using Random Forests

Hartanto, M.; Sani, A. A.; de Ridder, D.; Nijveen, H.

10.1101/2022.04.06.487194 — plant biology — Posted on 2022-04-09

2674 Tissue-Specific Transcriptome Responses to Fusarium Head Blight and Fusarium Root Rot

Haidoulis, J. F.; Nicholson, P.

10.1101/2022.04.07.487462 — plant biology — Posted on 2022-04-09

2675 The senescence regulator S40 family members from Caragana intermedia and Arabidopsis thaliana inhibit leaf senescence via promoting cytokinins synthesis

Li, G.; Yang, T.; Zhang, M.; Yang, Q.; Liu, K.; Cui, J.; Chen, J.; Ren, Y.; Shao, Y.; Wang, R.

10.1101/2022.04.08.487715 — plant biology — Posted on 2022-04-09

2676 Functional divergence of the bag of marbles gene in the Drosophila melanogaster species group

Bubnell, J. E.; Ulbing, C. K.; Fernandez Begne, P.; Aquadro, C. F.

10.1101/2021.06.25.449946 — genetics — Posted on 2022-04-09

2677 Machine learning improves global models of plant diversity

Cai, L.; Kreft, H.; Taylor, A.; Denelle, P.; Schrader, J.; Essl, F.; Kleunen, M. v.; Pergl, J.; Pysek, P.; Stein, A.; Winter, M.; Barcelona, J. F.; Fuentes, N.; Inderjit, ; Karger, D. N.; Kartesz, J.; Kuprijanov, A.; Nishino, M.; Nickrent, D.; Nowak, A.; Patzelt, A.; Pelser, P. B.; Singh, P.; Wieringa, J. J.; Weigelt, P.

10.1101/2022.04.08.487610 — ecology — Posted on 2022-04-09

2678 An ALS-associated mutant KIF5A forms oligomers and aggregates and induces neuronal toxicity

Nakano, J.; Chiba, K.; Niwa, S.

10.1101/2022.03.28.486133 — cell biology — Posted on 2022-04-09

2679 Antibiotic-producing Micrococcales govern the microbiome that inhabits the fur of two- and three-toed sloths

Rojas-Gatjens, D.; Valverde-Madrigal, K. S.; Rojas-Jimenez, K.; Pereira, R.; Avey-Arroyo, J.; Chavarria, M.

10.1101/2022.04.08.486316 — microbiology — Posted on 2022-04-09

2680 TemplateFlow: FAIR-sharing of multi-scale, multi-species brain models

Ciric, R.; Thompson, W. H.; Lorenz, R.; Goncalves, M.; MacNicol, E.; Markiewicz, C.; Halchenko, Y.; Ghosh, S. S.; Gorgolewski, K. J.; Poldrack, R.; Esteban, O.

10.1101/2021.02.10.430678 — neuroscience — Posted on 2022-04-09

2681 Spatial and temporal autocorrelation weave complexity in brain networks

Shinn, M.; Hu, A.; Turner, L.; Noble, S.; Preller, K. H.; Ji, J. L.; Moujaes, F.; Achard, S.; Scheinost, D.; Constable, R. T.; Krystal, J.; Vollenweider, F. X.; Lee, D.; Anticevic, A.; Bullmore, E. T.; Murray, J. D.

10.1101/2021.06.01.446561 — neuroscience — Posted on 2022-04-09

2682 Representation of motion concepts in occipitotemporal cortex: fMRI activation, decoding and connectivity analyses

Zhang, Y.; Lemarchand, R.; Asyraff, A.; Hoffman, P.

10.1101/2021.09.30.462531 — neuroscience — Posted on 2022-04-09

2683 TAS-Seq: a robust and sensitive amplification method for bead-based scRNA-seq

Shichino, S.; Ueha, S.; Hashimoto, S.; Ogawa, T.; Aoki, H.; Wu, B.; Chen, C.-Y.; Kitabatake, M.; Ouji-Sageshima, N.; Hontsu, S.; Sawabata, N.; Kawaguchi, T.; Okayama, T.; Sugihara, E.; Ito, T.; Iwata, Y.; Wada, T.; Ikeo, K.; Sato, T.-a.; Matsushima, K.

10.1101/2021.08.03.454735 — genomics — Posted on 2022-04-09

2684 Development of a monoclonal antibody to a vibriophage as a proxy for Vibrio cholerae detection

Sayeed, M. A.; Paisie, T.; Alam, M. T.; Ali, A.; Camilli, A.; Wrammert, J.; Khan, A. I.; Qadri, F.; Salemi, M.; Morris, J. G.; Nelson, E. J.

10.1101/2022.04.08.487661 — immunology — Posted on 2022-04-09

2685 In Silico Improvement of Highly Protective Anti-Malarial Antibodies

Mateo, M.; Tripathi, P.; Da Silva Pereira, L.; Kiyuka, P.; Liu, T.; Zhang, B.; Yang, Y.; Bonilla, B. G.; Dillon, M.; Lee, M.; Shen, C.-H.; Schon, A.; Kratochvil, S.; Batista, F. D.; Idris, A. H.; Seder, R. A.; Kwong, P. D.; Rawi, R.

10.1101/2022.04.08.487687 — immunology — Posted on 2022-04-09

2686 Hemispheric Asymmetries of Individual Differences in Functional Connectivity

Perez, D. C.; Dworetsky, A. M.; Braga, R. M.; Beeman, M.; Gratton, C.

10.1101/2022.04.08.487658 — neuroscience — Posted on 2022-04-09

2687 Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood

Castell, A.-L.; Ethier, M.; Fergusson, G.; Tremblay, C.; Goubault, C.; Baltz, M.; Dal Soglio, D.; Ghislain, J.; Poitout, V.

10.1101/2022.04.06.487366 — physiology — Posted on 2022-04-09

2688 Effective drug release from safe ultrasound-triggered nanocarriers

Wilson, M. G.; Kubanek, J.

10.1101/2021.12.14.471689 — bioengineering — Posted on 2022-04-09

2689 The {varphi}PA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice

Nieweglowska, E. S.; Brilot, A. F.; Mendez, M.; Baek, M.; Li, J.; Kokontis, C.; Cheng, Y.; Baker, D.; Bondy-Denomy, J.; Agard, D. A.

10.1101/2022.04.06.487387 — biochemistry — Posted on 2022-04-08

2690 Cryo-EM reveals an entangled kinetic trap in the folding pathway of a catalytic RNA

Bonilla, S. L.; Vicens, Q.; Kieft, J. S.

10.1101/2022.04.05.487152 — biochemistry — Posted on 2022-04-09

2691 Structural and biophysical properties of FopA, a major outer membrane protein of Francisella tularensis

Fromme, P.; Nagaratnam, N.; Martin-Garcia, J. M.; Yang, J.-H.; Goode, M. R.; Ketalawa, G.; Craciunescu, F. M.; Zook, J. D.; Grant, T. D.; Fromme, R.; Hansen, D. T.

10.1101/2022.04.08.487631 — biochemistry — Posted on 2022-04-09

2692 Transcription factors organize into functional groups on the linear genome and in 3D chromatin

Vadnala, R. N.; Hannenhalli, S.; Narlikar, L.; Siddharthan, R.

10.1101/2022.04.06.487423 — genomics — Posted on 2022-04-08

2693 Developmental system drift in one tooth facilitates the adaptation of the other tooth

Semon, M.; Gueguen, L.; Steklikova, K.; Mouginot, M.; Peltier, M.; Veber, P.; Pantalacci, S.

10.1101/2020.04.22.043422 — evolutionary biology — Posted on 2022-04-08

2694 Photoperiod modulates mu-opioid receptor availability in brown adipose tissue

Sun, L.; Aarnio, R.; Herre, E. A.; Karna, S.; Palani, S.; Virtanen, H.; Liljenback, H.; Virta, J.; Honkaniemi, A.; Oikonen, V.; Han, C.; Laurila, S.; Bucci, M.; Helin, S.; Yatkin, E.; Nummenmaa, L.; Nuutila, P.; Tang, J.; Roivainen, A.

10.1101/2022.04.08.487600 — molecular biology — Posted on 2022-04-09

2695 The Neural Response at the Fundamental Frequency of Speech is Modulated by Word-level Acoustic and Linguistic Information

Kegler, M.; Weissbart, H.; Reichenbach, T.

10.1101/2022.04.08.487621 — neuroscience — Posted on 2022-04-08

2696 Learning and Expression of Dopaminergic Reward Prediction Error via Plastic Representations of Time

Cone, I.; Clopath, C.; Shouval, H.

10.1101/2022.04.06.487298 — neuroscience — Posted on 2022-04-08

2697 The natural diversity of the yeast proteome reveals chromosome-wide dosage compensation in aneuploids

Muenzner, J.; Trebulle, P.; Agostini, F.; Messner, C. B.; Steger, M.; Lehmann, A.; Caudal, E.; Egger, A.-S.; Amari, F.; Barthel, N.; De Chiara, M.; Muelleder, M.; Demichev, V.; Liti, G.; Schacherer, J.; Gossmann, T.; Berman, J.; Ralser, M.

10.1101/2022.04.06.487392 — systems biology — Posted on 2022-04-08

2698 DOMINANT AWN INHIBITOR encodes the ALOG protein originating from gene duplication and inhibits awn elongation by suppressing cell proliferation and elongation in sorghum

Takanashi, H.; Kajiya-Kanegae, H.; Nishimura, A.; Yamada, J.; Ishimori, m.; Kobayashi, M.; Yano, K.; Iwata, H.; Tsutsumi, N.; Sakamoto, W.

10.1101/2021.09.29.462495 — plant biology — Posted on 2022-04-08

2699 High temperature increases centromere-mediated genome elimination frequency in Arabidopsis deficient in cenH3 or its assembly factor KNL2

Ahmadli, U.; Kalidass, M.; Khaitova, L. C.; Fuchs, J.; Cuacos, M.; Demidov, D.; Zuo, S.; Pecinkova, J.; Ingouff, M.; Mascher, M.; Heckmann, S.; Houben, A.; Riha, K.; Lermontova, I.

10.1101/2022.03.24.485459 — plant biology — Posted on 2022-04-08

2700 Flotillin-2 regulates EGFR activation, degradation, and cancer growth

Wisniewski, D. J.; Liyasova, M. S.; Korrapati, S.; Zhang, X.; Gilbert, S. F.; Catalano, A.; Voeller, D.; Guha, U. J.; Porat-Shliom, N.; Annunziata, C.; Lipkowitz, S.

10.1101/2022.03.11.483779 — cancer biology — Posted on 2022-04-08

2701 Invadopodia enable cooperative invasion and metastasis of breast cancer cells

Perrin, L.; Belova, E.; Bayarmagnai, B.; Tuzel, E.; Gligorijevic, B.

10.1101/2021.02.13.431047 — cancer biology — Posted on 2022-04-08

2702 Inferring bound structure and residue specific contributions to binding energetics in the Intrinsically Disordered Protein, CcdA

Chandra, S.; Manjunath, K.; Asok, A.; Varadarajan, R.

10.1101/2022.04.08.487678 — biophysics — Posted on 2022-04-08

2703 Different factors drive community assembly of rare and common ectomycorrhizal fungi

van Galen, L. G.; Orlovich, D. A.; Lord, J. M.; Bohorquez, J.; Nilsen, A. R.; Summerfield, T. C.; Larcombe, M. J.

10.1101/2022.04.06.487384 — ecology — Posted on 2022-04-08

2704 Analysing economic costs of invasive alien species with the invacost R package

Leroy, B.; Kramer, A. M.; Vaissiere, A.-C.; Kourantidou, M.; Courchamp, F.; Diagne, C.

10.1101/2020.12.10.419432 — ecology — Posted on 2022-04-08

2705 Effects of seasonal changes on the carbon dynamics in mixed coniferous forests

Gao, T.; Song, X.; Ren, Y.; Liu, H.; Dong, X.

10.1101/2022.04.08.487629 — ecology — Posted on 2022-04-08

2706 Distal-less homeobox genes Dlx5/6 regulate Mulllerian duct regression

Mullen, R. D.; Bellessort, B.; Levi, G.; Behringer, R. D.

10.1101/2022.04.08.487506 — developmental biology — Posted on 2022-04-08

2707 Essential bromodomain TcBDF2 as a drug target against Chagas disease

Pezza, A.; Tavernelli, L. E.; Alonso, V. L.; Perdomo, V. G.; Gabarro, R. C.; Prinjha, R.; Rodriguez Araya, E.; Rioja, I.; Docampo, R.; Calderon, F.; Martin, J. J.; Serra, E.

10.1101/2022.01.25.477728 — cell biology — Posted on 2022-04-08

2708 Structure of Importin-4 bound to the H3-H4·ASF1 histone·histone chaperone complex

Bernardes, N. E.; Fung, H. Y. J.; Li, Y.; Chen, Z.; Chook, Y. M.

10.1101/2022.04.08.487665 — molecular biology — Posted on 2022-04-08

2709 Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney

Liu, S.; Xia, X.; Zhen, J.; Li, Z.; Zhou, Z. H.

10.1101/2022.04.06.487412 — molecular biology — Posted on 2022-04-08

2710 The two-component system ChvGI maintains cell envelope homeostasis in Caulobacter crescentus

Quintero-Yanes, A.; Mayard, A.; Hallez, R.

10.1101/2022.01.18.476748 — microbiology — Posted on 2022-04-08

2711 The Resting-State Causal Human Connectome is Characterized by Hub Connectivity of Executive and Attentional Networks

Rawls, E.; Kummerfeld, E.; Mueller, B. A.; Ma, S.; Zilverstand, A.

10.1101/2021.10.20.465211 — neuroscience — Posted on 2022-04-08

2712 Rhythmic coordination of hippocampal-prefrontal ensembles for odor-place associative memory and decision making

Symanski, C. A.; Bladon, J. H.; Kullberg, E. T.; Miller, P.; Jadhav, S. P.

10.1101/2020.06.08.140939 — neuroscience — Posted on 2022-04-08

2713 Discovery and Visualization of Age-dependent Patterns in the Diurnal Transcriptome of Drosophila

Sebastian, B.; Fey, R.; Morar, P.; Lasher, B.; Chow, E.; Giebultowicz, J.; Hendrix, D. A.

10.1101/2022.04.06.487011 — systems biology — Posted on 2022-04-08

2714 The Effect of Ligands and Transducers on the Neurotensin Recep-tor 1 (NTS1) Conformational Ensemble

Dixon, A. D.; Inoue, A.; ROBSON, S. A.; Culhane, K.; Trinidad, J.; Sivaramakrishnan, S.; Bumbak, F.; Ziarek, J. J.

10.1101/2021.12.08.471782 — biophysics — Posted on 2022-04-08

2715 RATTLE: Reference-free reconstruction and quantification of transcriptomes from Nanopore sequencing

de la Rubia, I.; Srivastava, A.; Xue, W.; Indi, J. A.; Carbonell-Sala, S.; Lagarde, J.; Alba, M. M.; Eyras, E.

10.1101/2020.02.08.939942 — bioinformatics — Posted on 2022-04-08

2716 Metrics of High Cofluctuation and Entropy to Describe Control of Cardiac Function in the Stellate Ganglion

Gurel, N. Z.; Sudarshan, K. B.; Hadaya, J.; Karavos, A.; Temma, T.; Hori, Y.; Armour, A. J.; Kember, G.; Ajijola, O. A.

10.1101/2021.09.28.462183 — bioengineering — Posted on 2022-04-08

2717 Nucleosome patterns in four plant pathogenic fungi with contrasted genome structures

Clairet, C.; LAPALU, N.; Simon, A.; Soyer, J. L.; Viaud, M.; Zehraoui, E.; Dalmais, B.; Fudal, I.; Ponts, N.

10.1101/2021.04.16.439968 — genomics — Posted on 2022-04-08

2718 Interpretable deep generative models for genomics

Choi, Y.; Li, R.; Quon, G.

10.1101/2021.09.15.460498 — genomics — Posted on 2022-04-08

2719 Organisation of gene programs revealed by unsupervised analysis of diverse gene-trait associations

Mizikovsky, D.; Naval Sanchez, M.; Nefzger, C. M.; Cuellar Partida, G.; Palpant, N.

10.1101/2022.04.07.487559 — genomics — Posted on 2022-04-08

2720 Co-Component Signal Transduction Systems: fast-evolving virulence regulation cassettes discovered in enteric bacteria

Kinch, L. N.; Cong, Q.; Jaishankar, J.; Orth, K.

10.1101/2022.04.08.487670 — evolutionary biology — Posted on 2022-04-08

2721 Multiple lines of evidence indicate survival of the Ivory-billed Woodpecker in Louisiana

Latta, S. C.; Michaels, M. A.; Scheifler, D.; Michot, T. C.; Shrum, P. L.; Johnson, P.; Tischendorf, J.; Weeks, M.; Trochet, J.; Ford, B.

10.1101/2022.04.06.487399 — ecology — Posted on 2022-04-08

2722 Soil water consumption characteristics in rain-fed apple orchards and wheat fields

Zhang, L.

10.1101/2022.04.08.487632 — ecology — Posted on 2022-04-08

2723 Wax worm saliva and the enzymes therein are the key to polyethylene degradation by Galleria mellonella

Sanluis-Verdes, A.; Colomer-Vidal, P.; Rodriguez-Ventura, F.; Bello-Villarino, M.; Spinola-Amilibia, M.; Ruiz-Lopez, E.; Illanes-Vicioso, R.; Castroviejo, P.; Aiese Cigliano, R.; Montoya, M.; Falabella, P.; Pesquera, C.; Gonzalez-Legarreta, L.; Arias-Palomo, E.; Sola, M.; Torroba, T.; Arias, C. F.; Bertocchini, F.

10.1101/2022.04.08.487620 — molecular biology — Posted on 2022-04-08

2724 Dietary and Reproductive Traits of Two Brachyuran Crab Species

Potter, B. D.; Cannizzo, Z. J.; Griffen, B. D.

10.1101/2022.04.08.487630 — ecology — Posted on 2022-04-08

2725 Isoforms of the transcriptional cofactor SIN3 differentially regulate genes necessary for energy metabolism and cell survival

Mitra, A.; Vo, L.; Soukar, I.; Chaubal, A.; Greenberg, M.; Pile, L.

10.1101/2021.12.31.474661 — molecular biology — Posted on 2022-04-08

2726 Oct1 recruits the histone lysine demethylase Utx to promote lineage specification

Perovanovic, J.; Wu, Y.; Shen, Z.; Hughes, E.; Chandrasekharan, M. B.; Tantin, D.

10.1101/2020.12.01.406488 — developmental biology — Posted on 2022-04-08

2727 Pneumococcus triggers NFkB degradation in COMMD2 aggresome-like bodies.

Connor, M. G.; Sanchez, L.; Chevalier, C.; Carvalho, F.; Eldridge, M. J. G.; Chaze, T.; Matondo, M.; Weight, C.; Heyderman, R. S.; Enninga, J.; Hamon, M. A.

10.1101/2022.04.08.487599 — microbiology — Posted on 2022-04-08

2728 Cardio PyMEA: A user-friendly, open-source Python application for cardiomyocyte microelectrode array analysis

Dunham, C. S.; Mackenzie, M. E.; Nakano, H.; Kim, A. R.; Nakano, A.; Stieg, A. Z.; Gimzewski, J. K.

10.1101/2022.03.25.485780 — cell biology — Posted on 2022-04-08

2729 Hepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses

Kardia, E.; Fakhri, O.; Pavy, M.; Mason, H.; Huang, N.; Smertina, E.; Estes, M. K.; Strive, T.; Frese, M.; Hall, R. N.

10.1101/2022.04.07.487566 — microbiology — Posted on 2022-04-08

2730 A CRISPR-based instant DNA repositioning system and the early intranuclear life of HSV-1

Xu, P.; Fan, Z.; Xiang, J.

10.1101/2022.04.08.487454 — microbiology — Posted on 2022-04-08

2731 Molecular Architecture of the Chikungunya Virus Replication Complex

Tan, Y. B.; Chmielewski, D.; Law, M. C. Y.; Zhang, K.; He, Y.; Chen, M.; Jin, J.; Luo, D.; Chiu, W.

10.1101/2022.04.08.487651 — microbiology — Posted on 2022-04-08

2732 Intestinal inflammation reversibly alters the microbiota to drive susceptibility to Clostridioides difficile colonization in a mouse model of colitis

Barron, M. R.; Sovacool, K. L.; Abernathy-Close, L.; Vendrov, K. C.; Standke, A.; Bergin, I. L.; Schloss, P. D.; Young, V. B.

10.1101/2022.04.07.487579 — microbiology — Posted on 2022-04-08

2733 The RNA-RNA interactome between a phage and its satellite virus reveals a small RNA differentially regulates gene expression across both genomes

Dunham, D. T.; Angermeyer, A.; Seed, K.

10.1101/2022.04.08.487710 — microbiology — Posted on 2022-04-08

2734 A new microfluidic device for simultaneous detection of enzyme secretion and elongation of a single hypha

Itani, A.; Shida, Y.; Ogasawara, W.

10.1101/2022.04.07.487578 — microbiology — Posted on 2022-04-08

2735 Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus

Antonopoulos, A.; Doyle, S.; Bartley, D. J.; Morrison, A. A.; Kaplan, R.; Howell, S.; Neveu, C.; Busin, V.; Devaney, E.; Laing, R.

10.1101/2022.04.08.487639 — microbiology — Posted on 2022-04-08

2736 Ultra-high-throughput microbial single-cell whole genome sequencing for genome-resolved metagenomics

Li, J.; Zhang, R.; Li, T.; Shi, Q.; Song, Z.; Jiang, L.; Shi, Y.; Ma, C.; Liang, X.; Zhang, J.; Liu, Y.

10.1101/2022.04.08.485055 — microbiology — Posted on 2022-04-08

2737 Antibiotic-producing Micrococcales govern the microbiome that inhabits the fur of two- and three-toed sloths

Rojas-Gätjens, D.; Valverde-Madrigal, K. S.; Rojas-Jimenez, K.; Pereira, R.; Avey-Arroyo, J.; Chavarria, M.

10.1101/2022.04.08.486316 — microbiology — Posted on 2022-04-08

2738 A pathogenicity locus of Streptococcus gallolyticus subspecies gallolyticus

Taylor, J. C.; Kumar, R.; Xu, J.; Xu, Y.

10.1101/2022.03.15.484266 — microbiology — Posted on 2022-04-08

2739 A Rapid, High Throughput, Viral Infectivity Assay using Automated Brightfield Microscopy with Machine Learning

Dodkins, R. H.; Delaney, J. R.; Overton, T.; Scholle, F.; Frias, A.; Crisci, E.; Huq, N.; Jordan, I.; Kimata, J. T.; Goldberg, I. G.

10.1101/2022.03.23.485512 — microbiology — Posted on 2022-04-08

2740 Acod1 negatively impacts osteoclastogenesis via GPR91-mediated NFATc1 activation

Gao, Y.; Kraus, F. V.; Seebach, E.; Chakraborty, S.; Schaack, D.; Schenz, J.; Wagner, W.; Kubatzky, K.

10.1101/2022.04.07.487467 — immunology — Posted on 2022-04-08

2741 Fecal immunoglobulin A (IgA) and its subclasses in systemic lupus erythematosus patients are nuclear antigen reactive and this feature correlates with gut permeability marker levels

Gudi, R.; Kamen, D.; Vasu, C.

10.1101/2022.01.26.477918 — immunology — Posted on 2022-04-08

2742 TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to circulating, non-infectious immature dengue virus particles

Aguilar Briseno, J. A.; Ramos Pereira, L.; van der Laan, M.; Pauzuolis, M.; ter Ellen, B. M.; Upasani, V.; Moser, J.; de Souza Ferreira, L. C.; Smit, J. M.; Rodenhuis-Zybert, I. A.

10.1101/2022.04.07.487433 — immunology — Posted on 2022-04-08

2743 Gαq modulates the energy metabolism of osteoclasts

Chakraborty, S.; Handrick, B.; Yu, D.; Bode, K.; Hafner, A.; Schenz, J.; Schaack, D.; Uhle, F.; Tachibana, T.; Kamitani, S.; Vogl, T.; Kubatzky, K.

10.1101/2022.04.06.487374 — immunology — Posted on 2022-04-08

2744 NF kappa B Regulator Bcl3 Controls Development and Function of Classical Dendritic Cells in Toxoplasma gondii

Guha, J.; Kang, B.; Claudio, E.; Redekar, N. R.; Wang, H.; Kelsall, B. L.; Siebenlist, U.; Murphy, P. M.

10.1101/2022.04.07.487586 — immunology — Posted on 2022-04-08

2745 Robust Estimation of 1/f Activity Improves Oscillatory Burst Detection

Seymour, R. A.; Alexander, N.; Maguire, E. A.

10.1101/2022.03.24.485674 — neuroscience — Posted on 2022-04-08

2746 Separation of NaV Subtypes in the Axon InitialSegment can Impede or Promote Backpropagation

Barlow, B. S.; Longtin, A.; Joos, B.

10.1101/2022.04.01.486760 — neuroscience — Posted on 2022-04-08

2747 Single-neuron bursts encode pathological oscillations in Parkinson's disease and essential tremor

Scherer, M.; Steiner, L. A.; Kalia, S. K.; Hodaie, M.; Kuehn, A. A.; Lozano, A. M.; Hutchison, W. D.; Milosevic, L.

10.1101/2022.04.05.486956 — neuroscience — Posted on 2022-04-08

2748 Formalism for the sequential estimation of neural membrane time constant and input-output curve towards selective and closed-loop transcranial magnetic stimulation

Alavi, M.; Vila-Rodriguez, F.; Mahdi, A.; Goetz, S. M.

10.1101/2022.04.05.487065 — neuroscience — Posted on 2022-04-08

2749 Accounting for motion in resting-state fMRI: What part of the spectrum are we characterizing in autism spectrum disorder?

Nebel, M. B.; Lidstone, D.; Wang, L.; Benkeser, D.; Mostofsky, S. H.; Risk, B. B.

10.1101/2022.01.12.476077 — neuroscience — Posted on 2022-04-08

2750 High-throughput molecular recording can determine the identity and biological activity of sequences within single cells

Tu, B.; Esvelt, K.

10.1101/2022.03.09.483646 — synthetic biology — Posted on 2022-04-08

2751 Expression Analysis, Molecular Characterization and Prognostic Evaluation on TMED4 and TMED9 Gene Expression in Glioma

Ullah, M. A.; Tabassum, T.; Farzana, M.; Moin, A. T.; Zohora, U. S.; Rahman, M. S.

10.1101/2022.04.07.487570 — cancer biology — Posted on 2022-04-08

2752 Divergent MEK/ERK and AMPK signaling dictate lipogenic plasticity and dependence on fatty acid synthesis in Glioblastoma

Eyme, K.; Sammarco, A.; Jha, R.; MNATSAKANYAN, H.; Neustadt, R.; Moses, C.; Alnasser, A.; Tardiff, D.; Su, B.; Williams, K.; Bensinger, S.; Chung, C. Y.; badr, c. E.

10.1101/2022.04.07.487530 — cancer biology — Posted on 2022-04-08

2753 Recycling of Polymerase Chain Reaction (PCR) kits

Liu, W.; Stellacci, F.

10.1101/2022.04.08.487615 — biochemistry — Posted on 2022-04-08

2754 Oncogenic metabolic rewiring independent of proliferative control in human mammary epithelial cells

Dong, W.; Keibler, M. A.; Moon, S. J.; Cho, P.; Liu, N.; Berrios, C. J.; Kelleher, J.; Sikes, H. D.; Iliopoulos, O.; Coloff, J.; Vander Heiden, M.; Stephanopoulos, G.

10.1101/2022.04.08.486845 — biochemistry — Posted on 2022-04-08

2755 NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responses

Rydyznski Moderbacher, C.; Kim, C.; Mateus, J.; Plested, J.; Zhu, M.; Cloney-Clark, S.; Weiskopf, D.; Sette, A.; Fries, L.; Glenn, G.; Crotty, S.

10.1101/2022.04.08.487674 — immunology — Posted on 2022-04-08

2756 D27-LIKE1 carotenoid isomerase has a preference towards trans/cis and cis/cis conversions in Arabidopsis

Gulyas, Z.; Moncsek, B.; Hamow, K. A.; Straner, P.; Badics, E.; Incze, N.; Darko, E.; Nagy, V.; Perczel, A.; Kovacs, L.; Soos, V.

10.1101/2022.04.06.487258 — plant biology — Posted on 2022-04-08

2757 Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases

Karaky, M.; Boucher, G.; Mola, S.; Foisy, S.; Beauchamp, C.; Rivard, M.-E.; Burnette, M.; Gosselin, H.; Consortium, i.; Bitton, A.; Charron, G.; Goyette, P.; Rioux, J. D.

10.1101/2022.04.06.487252 — genetics — Posted on 2022-04-08

2758 SARS-CoV-2 and its variants, but not Omicron, induces thymic atrophy and impaired T cell development

Rizvi, Z. A.; Sadhu, S.; Dandotiya, J.; Binayke, A.; Sharma, P.; Singh, V.; Das, V.; Khatri, R.; Kumar, R.; Samal, S.; Kalia, M.; Awasthi, A.

10.1101/2022.04.07.487556 — immunology — Posted on 2022-04-08

2759 SARS-CoV-2 mutations affect proteasome processing to alter CD8+ T cell responses

Wellington, D.; Yin, Z.; Yu, Z.; Heilig, R.; Davis, S.; Fischer, R.; Felce, S. L.; Hublitz, P.; Beveridge, R.; Dong, D.; Liu, G.; Yao, X.; Peng, Y.; Kessler, B. M. M.; Dong, T.

10.1101/2022.04.08.487623 — immunology — Posted on 2022-04-08

2760 A Novel Prognosis Model based on Comprehensive Analysis of Pyroptosis-Related Genes in Breast Cancer

Zeng, S.; Wang, Y.; Yang, Y.

10.1101/2022.04.05.486932 — bioinformatics — Posted on 2022-04-08

2761 A Systematic Evaluation of the Computational Tools for Ligand-receptor-based Cell-Cell Interaction Inference

Wang, S.; Zheng, H.; Choi, J. S.; Lee, J. K.; Li, X.; Hu, H.

10.1101/2022.04.05.487237 — bioinformatics — Posted on 2022-04-08

2762 Protein 3D structure-based neural networks highly improve the accuracy in compound-protein binding affinity prediction

Guo, B.; Zheng, H.; Huang, H.; Jiang, H.; Li, X.; Guan, N.; Zuo, Y.; Zhang, Y.; Yang, H.; Wang, X.

10.1101/2022.04.06.487274 — bioinformatics — Posted on 2022-04-08

2763 Design of an Integrated Microvascularised Human Skin-on-a-Chip Tissue Equivalent Model

Jones, C.; di Cio, S.; Connelly, J.; Gautrot, J.

10.1101/2022.04.06.487276 — bioengineering — Posted on 2022-04-08

2764 Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

Stalls, V.; Lindenberger, J.; Gobeil, S.; Henderson, R.; Parks, R.; Barr, M.; Deyton, M.; Martin, M.; Janowska, K.; Huang, X.; May, A.; Speakman, M.; Beaudoin, E.; Edwards, R. J.; Eaton, A.; Montefiori, D.; Williams, W.; Saunders, K. O.; Wiehe, K.; Haynes, B. F.; Acharya, P.

10.1101/2022.04.07.487528 — biochemistry — Posted on 2022-04-08

2765 The non-random assembly of functional motifs in plant-pollinator networks

Lanuza, J. B.; Allen-Perkins, A.; Bartomeus, I.

10.1101/2022.04.06.486621 — ecology — Posted on 2022-04-08

2766 Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response

Garcia, G.; Wang, Y.; Irudayam, J. I.; Jeyachandran, A. V.; Cario, S. C.; Sen, C.; Li, S.; Li, Y.; Kumar, A.; Nielsen-Saines, K.; French, S. W.; Shah, P. S.; Morizono, K.; Gomperts, B.; Deb, A.; Ramaiah, A.; Arumugaswami, V.

10.1101/2022.04.07.487520 — microbiology — Posted on 2022-04-08

2767 The Delta variant SARS-CoV-2 spike protein uniquely promotes aggregation of pseudotyped viral particles

Petersen, J. D.; Lu, J.; Fitzgerald, W.; Zhou, F.; Blank, P. S.; Matthies, D.; Zimmerberg, J.

10.1101/2022.04.07.487415 — microbiology — Posted on 2022-04-08

2768 ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice.

Hsieh, C.-J.; Hou, C.; Zhu, Y.; Lee, J. Y.; Kohli, N.; Gallagher, E.; Xu, K.; Lee, H.; Li, S.; McManus, M. J.; Mach, R. H.

10.1101/2022.04.05.487092 — neuroscience — Posted on 2022-04-08

2769 High frequency spike inference with particle Gibbs sampling

Diana, G.; Sermet, B. S.; DiGregorio, D. A.

10.1101/2022.04.05.487201 — neuroscience — Posted on 2022-04-08

2770 Neuroscout, a unified platform for generalizable and reproducible fMRI research

de la Vega, A.; Rocca, R.; Blair, R. W.; Markiewicz, C. J.; Mentch, J.; Kent, J. D.; Herholz, P.; Ghosh, S. S.; Poldrack, R. A.; Yarkoni, T.

10.1101/2022.04.05.487222 — neuroscience — Posted on 2022-04-08

2771 Formalism for the sequential estimation of neural membrane time constant and input-output curve towards selective and closed-loop transcranial magnetic stimulation

Alavi, M.; Vila-Rodriguez, F.; Mahdi, A.; Goetz, S. M.

10.1101/2022.04.05.487065 — neuroscience — Posted on 2022-04-08

2772 Topological Data Analysis of Human Brain Networks Through Order Statistics

Das, S.; Anand, D. V.; Chung, M. K.

10.1101/2022.04.06.487253 — neuroscience — Posted on 2022-04-08

2773 A snapshot of statistical methods used in experimental immunoblotting: A scoping review

Gosselin, R.-D.

10.1101/2022.04.06.487284 — scientific communication and education — Posted on 2022-04-08

2774 Isometric Spiracular Scaling in Scarab Beetles: Implications for Diffusive and Advective Oxygen Transport

Wagner, J. M.; Klok, C. J.; Duell, M. E.; Socha, J.; Cao, G.; Gong, H.; Harrison, J. F.

10.1101/2022.04.06.487277 — physiology — Posted on 2022-04-08

2775 Metformin disrupts Danio rerio metabolism at environmentally relevant concentrations: A generational study

Barros, S.; Ribeiro, M.; Coimbra, A. M.; Pinheiro, M.; Morais, H.; Alves, N.; Montes, R.; Rodil, R.; Quintana, J. B.; Santos, M. M.; Neuparth, T.

10.1101/2022.04.05.487223 — pharmacology and toxicology — Posted on 2022-04-08

2776 Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants

Ortega, J. T.; McKee, A. G.; Roushar, F. J.; Penn, W. D.; Schlebach, J. P.; Jastrzebska, B.

10.1101/2022.04.05.487228 — pharmacology and toxicology — Posted on 2022-04-08

2777 Identification and comparison of somatic antigen composition for bacteria from Providencia genus

Kuchur, P. D.; Churkina, A. I.; Rybina, A. A.; Komissarov, A. S.

10.1101/2022.04.05.486866 — bioinformatics — Posted on 2022-04-08

2778 scROSHI - robust supervised hierarchical identification of single cells

Prummer, M.; Bertolini, A.; Bosshard, L.; Barkmann, F.; Yates, J.; Boeva, V.; The TumorProfiler Consortium, ; Stekhoven, D. J.; Singer, F.

10.1101/2022.04.05.487176 — bioinformatics — Posted on 2022-04-08

2779 EcoFun-MAP: An Ecological Function Oriented Metagenomic Analysis Pipeline

Shi, Z. J.; Xiao, N.; Ning, D.; Tian, R.; Zhang, P.; Curtis, D.; Van Nostrand, J. D.; Wu, L.; Hazen, T. C.; Rocha, A. M.; He, Z.; Arkin, A. P.; Firestone, M. K.; Zhou, J.

10.1101/2022.04.05.481366 — bioinformatics — Posted on 2022-04-08

2780 Microphysiological Drug-Testing Platform For Identifying Responses To Prodrug Treatment In Primary Leukemia

Gokce, F.; Kaestli, A.; Lohasz, C.; de Geus, M.; Renggli, K.; Bornhauser, B.; Hierlemann, A.; Modena, M. M.

10.1101/2022.04.06.483760 — bioengineering — Posted on 2022-04-08

2781 Paired Associates Learning is Disrupted After Unilateral Parietal Lobe Controlled Cortical Impact in Rats: A Trial-by-Trial Behavioral Analysis

Smith, S. M.; Garcia, E. L.; Davidson, C.; Thompson, J.; Lovett, S.; Ferekides, N.; Federico, Q.; Bumanglag, A. V.; Hernandez, A. R.; Abisambra, J. M.; Burke, S. N.

10.1101/2022.04.05.487213 — animal behavior and cognition — Posted on 2022-04-08

2782 Integrating bulk and single cell RNA-seq refines transcriptomic profiles of specific C. elegans neurons.

Barrett, A.; Varol, E.; Weinreb, A.; Taylor, S. R.; McWhirter, R.; Cros, C.; Basavaraju, M.; Poff, A.; Tipps, J. A.; Majeed, M.; Vidal, B.; Wang, C.; Yemini, E.; Bayer, E. A.; Sun, H.; Hobert, O.; Miller, D. M.; Hammarlund, M.

10.1101/2022.04.05.487209 — genetics — Posted on 2022-04-08

2783 Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells

Zorzan, I.; Betto, R. M.; Rossignoli, G.; Arboit, M.; Drusin, A.; Martini, P.; Martello, G.

10.1101/2022.04.07.487453 — developmental biology — Posted on 2022-04-08

2784 Plant-produced RBD and cocktail-based vaccine candidates are highly effective against SARS-CoV-2, independently of its emerging variants

Mammedov, T.; Yuksel, D.; Grbzaslan, I.; Ilgn, M.; Gulec, B.; Mammadova, G.; Ozdarendeli, A.; Islam Pavel, S. T.; Yetiskin, H.; Kaplan, B.; Uygut, M. A.; Hasanova, G.

10.1101/2022.04.07.487347 — immunology — Posted on 2022-04-08

2785 Speech Production in Intracranial Electroencephalography: iBIDS Dataset

Verwoert, M.; Ottenhoff, M. C.; Goulis, S.; Colon, A. J.; Wagner, L.; Tousseyn, S.; van Dijk, J. P.; Kubben, P. L.; Herff, C.

10.1101/2022.04.05.487183 — neuroscience — Posted on 2022-04-08

2786 Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related cochlear synaptopathy and slows age-related hearing loss

Cassinotti, L. R.; Ji, L.; Borges, B. C.; Cass, N. D.; Desai, A. S.; Kohrman, D. C.; Liberman, M. C.; Corfas, G.

10.1101/2022.04.05.487225 — neuroscience — Posted on 2022-04-08

2787 Cytoneme-mediated transport of active Wnt5b/Ror2 complexes in zebrafish gastrulation

Zhang, C.; Brunt, L.; Rogers, S.; Scholpp, S.

10.1101/2022.04.07.487468 — developmental biology — Posted on 2022-04-08

2788 DOT1L activity affects cell lineage progression in the developing brain by controlling metabolic programs

Appiah, B.; Fullio, C.; Haffner, C.; Zeis, P.; Treppner, M.; Bovio, P. P.; Cheffer, A.; Bertani, I.; Binder, H.; Gruen, D.; Kalebic, N.; Taverna, E.; Vogel, T.

10.1101/2022.04.08.487591 — developmental biology — Posted on 2022-04-08

2789 Intraspecific diversity based on low temperature induced arrhythmia in embryonic heart of medaka (Oryzias latipes)

Yoshimura, W.; Oda, S.; Katsumura, T.; Mitani, H.; Watanabe-Asaka, T.

10.1101/2022.04.05.487105 — developmental biology — Posted on 2022-04-08

2790 A Comprehensive Roadmap of Human Placental Development in vitro

Slamecka, J.; Tristan, C. A.; Ryu, S.; Chu, P.-H.; Weber, C.; Deng, T.; Gedik, Y.; Ormanoglu, P.; Michael, S.; Voss, T. C.; Simeonov, A.; Singec, I.

10.1101/2022.04.07.487558 — developmental biology — Posted on 2022-04-08

2791 Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production

Demy, D. L.; Touret, A.-L.; Lancino, M.; Tauzin, M.; Capuana, L.; Pierre, C.; Herbomel, P.

10.1101/2022.04.06.487382 — developmental biology — Posted on 2022-04-08

2792 The HH-GLI2-CKS1B network regulates the proliferation-to-maturation transition of human cardiomyocytes

Waldron, C. J.; Kelly, L.; Kawakami, Y.; Abrahante, J. E.; Magli, A.; Ogle, B. M.; Singh, B. N.

10.1101/2022.04.05.487243 — developmental biology — Posted on 2022-04-08

2793 Dictyostelium discoideum cells sense their local density and retain nutrients when the cells are about to overgrow their food source

Rijal, R.; Kirolos, S. A.; Rahman, R. J.; Gomer, R.

10.1101/2022.04.08.487657 — cell biology — Posted on 2022-04-08

2794 Redox regulation of yeast Hsp70 modulates protein quality control while directly triggering an Hsf1-dependent cytoprotective response

Santiago, A.; Morano, K. A.

10.1101/2022.04.08.487668 — cell biology — Posted on 2022-04-08

2795 Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle

Suresh, P.; Galstyan, V.; Phillips, R.; Dumont, S.

10.1101/2022.04.08.487649 — biophysics — Posted on 2022-04-08

2796 Parallel cryo electron tomography on in situ lamellae

Eisenstein, F.; Yanagisawa, H.; Kashihara, H.; Kikkawa, M.; Tsukita, S.; Danev, R.

10.1101/2022.04.07.487557 — biophysics — Posted on 2022-04-08

2797 Myosin Heavy Chain Converter Domain Mutations Drive Early-Stage Changes in Extracellular Matrix Dynamics in Hypertrophic Cardiomyopathy

Hsieh, J.; Becklin, K.; Givens, S.; Komosa, E. R.; Abrahante Llorens, J. E.; Kamdar, F.; Moriarity, B. S.; Webber, B. R.; Singh, B. N.; Ogle, B. M.

10.1101/2022.04.05.487211 — bioengineering — Posted on 2022-04-08

2798 Hydrogens and hydrogen-bond networks in macromolecular MicroED data

Clabbers, M. T. B.; Martynowycz, M. W.; Hattne, J.; Gonen, T.

10.1101/2022.04.08.487606 — biochemistry — Posted on 2022-04-08

2799 A dominant negative mutation uncovers cooperative control of caudal Wolffian Duct development by Sprouty genes

Altes, G.; Vaquero, M.; Cuesta, S.; Anerillas, C.; Macia, A.; Espinet, C.; Ribera, J.; Bellusci, S.; Klein, O. D.; Yeramian, A.; Dolcet, X.; Egea, J.; Encinas, M.

10.1101/2022.04.07.487514 — developmental biology — Posted on 2022-04-08

2800 Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells

Cichon, M. A.; Pfisterer, K.; Leitner, J.; Wagner, L.; Staud, C.; Steinberger, P.; Elbe-Bürger, A.

10.1101/2022.04.08.487626 — cell biology — Posted on 2022-04-08

2801 Primary cilia loss promotes reactivation of morphogenesis and cyst-fission through a deregulated TGFβ-ECM-Integrin axis in polycystic liver disease.

Waddell, S. H.; Yao, Y.; Olaizola, P.; Jarman, E. J.; Gournopanos, K.; Christodoulou, E.; Gautier, P.; Drenth, J. P.; Kendall, T. J.; Banales, J. M.; Khamseh, A.; Mill, P.; Boulter, L.

10.1101/2022.04.08.487546 — cell biology — Posted on 2022-04-08

2802 Heat and humidity sensors that alert mosquitoes to nearby human hosts

Garrity, P. A.; Laursen, W. J.; Budelli, G.; Chang, E. C.; Gerber, R.; Tang, R.; Greppi, C.; Albuquerque, R.

10.1101/2022.04.05.487046 — neuroscience — Posted on 2022-04-08

2803 An EcR probe reveals mechanisms of the ecdysone-mediated switch from repression-to-activation on target genes in the larval wing disc

Wardwell-Ozgo, J.; Terry, D. E.; Schweibenz, C. K.; Tu, M. Z.; Soliman, O.; Schofield, D.; Moberg, K.

10.1101/2022.04.07.487542 — developmental biology — Posted on 2022-04-08

2804 A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during ageing and in Alzheimer's disease

Jones, M. E.; Buechler, J.; Dufor, T.; Boroviak, K.; Metzakopian, E.; Gibb, A.; Salinas, P. C.

10.1101/2022.04.06.487208 — neuroscience — Posted on 2022-04-08

2805 Excess ribosomal protein production unbalances translation in Fragile X Syndrome

Seo, S. S.; Louros, S. R.; Anstey, N.; Gonzalez-Lazano, M. A.; Thomson, S. R.; Harper, C.; Verity, N.; Darnell, J. C.; Li, K. W.; Kind, P. C.; Osterweil, E. K.

10.1101/2022.04.07.487442 — neuroscience — Posted on 2022-04-08

2806 Recut: a Concurrent Framework for Sparse Reconstruction of Neuronal Morphology

Marrett, K.; Zhu, M.; Chi, Y.; Chen, Z.; Choi, C.; Dong, H.-W.; Park, C. S.; Cong, J.; Yang, X. W.

10.1101/2021.12.07.471686 — neuroscience — Posted on 2022-04-08

2807 Sexual dimorphism versus biomechanical loading in occipital bone morphological variation

Hoover, K. C.; Thomas, G.

10.1101/2022.04.05.487198 — physiology — Posted on 2022-04-08

2808 Functional plasticity and recurrent cell states of malignant B cells in follicular lymphoma

Attaf, N.; Dong, C.; Gil, L.; Cervera-Marzal, I.; Gharsalli, T.; Navarro, J.-M.; Mboumba, D.-L.; Chasson, L.; Lemonnier, F.; Gaulard, P.; Roulland, S.; Spinelli, L.; Nadel, B.; Milpied, P.

10.1101/2022.04.06.487285 — cancer biology — Posted on 2022-04-08

2809 Mathematical models of tumor volume dynamics in response to radiotherapy

Mohsin, N.; Enderling, H. U.; Brady-Nicholls, R.; Zahid, M. U.

10.1101/2022.04.07.487525 — cancer biology — Posted on 2022-04-08

2810 SOX9 binds TCFs to mediate Wnt/β catenin target gene activation

Ramakrishnan, A.-B.; Burby, P. E.; Adiga, K.; Cadigan, K. M.

10.1101/2022.04.06.487337 — cancer biology — Posted on 2022-04-08

2811 Deploying genomics workflows on high performance computing (HPC) platforms: storage, memory, and compute considerations

Powers, M.; Mannthey, K.; Sebastian, P.; Adsule, S.; Kiernan, E.; Smith, J. T.; Way, J.; Shifaw, B.; Roazen, D.; Narvaez, P.

10.1101/2022.04.05.485833 — bioinformatics — Posted on 2022-04-08

2812 Epistasis between synonymous and nonsynonymous mutations in Dictyostelium discoideum ammonium transporter amtA drives functional complementation in Saccharomyces cerevisiae.

Densi, A.; Iyer, R. S.; Bhat, P. J.

10.1101/2022.04.05.486919 — genetics — Posted on 2022-04-08

2813 Reactive Oxygen Species Signaling Differentially Controls Wound Healing and Regeneration

Van Huizen, A. V.; Hack, S. J.; Greene, J. M.; Kinsey, L. J.; Beane, W. S.

10.1101/2022.04.05.487111 — developmental biology — Posted on 2022-04-08

2814 Unaltered T cell responses to common antigens in individuals with Parkinson's disease

Williams, G. P.; Muskat, K.; Frazier, A.; Xu, Y.; Mateus, J.; Grifoni, A.; Antunes, R. d. S.; Weiskopf, D.; Amara, A. W.; Standaert, D. G.; Goldman, J. G.; Litvan, I.; Alcalay, R. N.; Sulzer, D.; Arlehamn, C. S. L.; Sette, A.

10.1101/2022.04.05.487195 — immunology — Posted on 2022-04-08

2815 Propofol disrupts alpha dynamics in distinct thalamocortical networks underlying sensory and cognitive function during loss of consciousness

Weiner, V. S.; Zhou, D. W.; Kahali, P.; Stephen, E. P.; Peterfreund, R. A.; Aglio, L. S.; Szabo, M. D.; Eskandar, E. N.; Salazar-Gomez, A. F.; Sampson, A. L.; Cash, S. S.; Brown, E. N.; Purdon, P. L.

10.1101/2022.04.05.487190 — neuroscience — Posted on 2022-04-08

2816 Mapping phenotypic heterogeneity in melanoma onto the epithelial-hybrid-mesenchymal axis

Pillai, M.; Rajaram, G.; Thakur, P.; Agarwal, N.; Muralidharan, S.; Ray, A.; Somarelli, J.; Jolly, M. K.

10.1101/2022.04.05.485702 — cancer biology — Posted on 2022-04-08

2817 RNA decay defines the therapeutic response to transcriptional perturbation in cancer

Todorovski, I.; Feran, B.; Fan, Z.; Gadipally, S.; Yoannidis, D.; Kong, I. Y.; Hawkins, E. D.; Simpson, K. J.; Mir Arnau, G.; Papenfuss, A. T.; Johnstone, R. W.; Vervoort, S. J.

10.1101/2022.04.06.487057 — cancer biology — Posted on 2022-04-08

2818 Modelling the spatial dynamics of oncolytic virotherapy in the presence of virus-resistant tumor cells

Bhatt, D. K.; Janzen, T.; Daemen, T.; Weissing, F. J.

10.1101/2022.04.06.487254 — cancer biology — Posted on 2022-04-08

2819 Divergent MEK/ERK and AMPK signaling dictate lipogenic plasticity and dependence on fatty acid synthesis in Glioblastoma

badr, c. E.; Eyme, K.; Sammarco, A.; Jha, R.; MNATSAKANYAN, H.; Neustadt, R.; Moses, C.; Alnasser, A.; Tardiff, D.; Su, B.; Williams, K.; Bensinger, S.; Chung, C. Y.

10.1101/2022.04.07.487530 — cancer biology — Posted on 2022-04-08

2820 Discovery of a novel mesothelin specific human antibody VH domain

Sun, Z.; Chu, X.; Adams, C.; Ilina, T. V.; Vergara, S.; Chen, C.; Jelev, D.; Ishima, R.; Li, W.; Mellors, J. W.; Calero, G.; Dimitrov, D. S.

10.1101/2022.04.07.487497 — cancer biology — Posted on 2022-04-08

2821 Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

Gruber, E.; So, J.; Lewis, A. C.; Franich, R.; Cole, R.; Martelotto, L. G.; Rogers, A. J.; Vidacs, E.; Fraser, P.; Stanley, K.; Jones, L.; Trigos, A. S.; Thio, N.; Li, J.; Nicolay, B.; Daigle, S.; Tron, A. E.; Hyer, M. L.; Shortt, J.; Johnstone, R. W.; Kats, L. M.

10.1101/2022.04.06.487420 — cancer biology — Posted on 2022-04-08

2822 Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

Guo, N.; Minas, G.; Synowsky, S. A.; Dunne, M. R.; Ahmed, H.; McShane, R.; Bhardwaj, A.; Donlon, N. E.; Lorton, C.; O'Sullivan, J.; Reynolds, J. V.; Caie, P. D.; Shirran, S. L.; Lynch, A. G.; Stewart, A.; Arya, S.

10.1101/2022.04.07.487448 — cancer biology — Posted on 2022-04-08

2823 Hypoxia-mediated suppression of pyruvate carboxylase drives tumor microenvironment immunosuppression

Coleman, M. F.; Cotul, E. K.; Pfeil, A. J.; Devericks, E. N.; Chen, H.; Kiesel, V. A.; Safdar, M.; Teegarden, D.; Hursting, S. D.; Wendt, M. K.

10.1101/2022.04.06.487050 — cancer biology — Posted on 2022-04-08

2824 A novel Pyk2-derived peptide inhibits invadopodia-mediated breast cancer metastasis

Twafra, S.; Sokolik, C.; Sneh, T.; Srikanth, K.; Meirson, T.; Genna, A.; Chill, J.; Gil-Henn, H.

10.1101/2022.04.06.487297 — cancer biology — Posted on 2022-04-08

2825 Chromatin accessibility and transcription factors in invasive lobular and ductal breast cancers

Lee, S.; Osmanbeyoglu, H. U.

10.1101/2022.04.08.487589 — cancer biology — Posted on 2022-04-08

2826 Cancer-associated fibroblast-derived ROR2 induces WNT/PCP activation and polarized migration in receiving gastric cancer cells.

Rogers, S.; Zhang, C.; Anagnostidis, V.; Gielen, F.; Fishel, M.; Scholpp, S.

10.1101/2022.04.07.487474 — cancer biology — Posted on 2022-04-08

2827 CMTM6 mediates cisplatin resistance in OSCC by regulating AKT/c-MYC driven ribosome biogenesis

Mohapatra, P.; Mohanty, S.; Ansari, S. A.; Shriwas, O.; Ghosh, A.; Rath, R.; Das Majumdar, S. K.; Swain, R. K.; Raghav, S. K.; Dash, R.

10.1101/2022.04.08.487634 — cancer biology — Posted on 2022-04-08

2828 Functional Contribution of Cancer-Associated Fibroblasts in Glioblastoma

Galbo, P. M.; Liu, Y.; Peng, M.; Wei, Y.; Madsen, A. T.; Graff, S.; Montagna, C.; Segall, J. E.; Sidoli, S.; Zang, X.; Zheng, D.

10.1101/2022.04.07.487495 — cancer biology — Posted on 2022-04-08

2829 Oncogenic signalling is coupled to colorectal cancer cell differentiation state

Sell, T.; Klotz, C.; Fischer, M. M.; Astaburuaga-Garciia, R.; Krug, S.; Drost, J.; Clevers, H.; Morkel, M.; Bluthgen, N.

10.1101/2022.04.07.487491 — cancer biology — Posted on 2022-04-08

2830 Bio-electric potentials in superior plants: electric collective behaviour

Chiolerio, A.; Dehshibi, M. M.; Vitiello, G.; Bernard, A.; Ceretto, P.; Arvat, M.; Adamatzky, A.

10.1101/2022.04.07.487233 — biophysics — Posted on 2022-04-08

2831 Amoeboid Cell Migration through Regular Arrays of Micropillars under Confinement

Sadjadi, Z.; Vesperini, D.; Laurent, A. M.; Barnefske, L.; Terriac, E.; Lautenschlaeger, F.; Rieger, H.

10.1101/2022.04.08.487483 — biophysics — Posted on 2022-04-08

2832 Identification and calibration of ultrabright localizations to eliminate quantification error in SMLM

Cao, B.; Ni, J.; Niu, G.; Chen, D.; Liu, G.; Zhou, L.; Xia, T.; Feng, F.; Wei, S.; Yuan, X.; Ni, Y.

10.1101/2022.04.06.487310 — biophysics — Posted on 2022-04-08

2833 Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators

Zhuang, Y.; Noviello, C. M.; Hibbs, R. E.; Howard, R. J.; Lindahl, E.

10.1101/2022.04.08.487470 — biophysics — Posted on 2022-04-08

2834 Long lifespan is maintained by a unique Heat Shock Factor in reproductive ants

Glastad, K. M.; Roessler, J.; Gospocic, J.; Berger, S. L.

10.1101/2022.04.07.487479 — genomics — Posted on 2022-04-08

2835 Inflammatory cytokines rewire the proinsulin interaction network in human islets

Tran, D.; Pottekat, A.; Lee, K.; Raghunathan, M.; Loguercio, S.; Mir, S. A.; Paton, A. W.; Paton, J. C.; Arvan, P.; Kaufman, R. J.; Itkin-Ansari, P.

10.1101/2022.04.07.487532 — cell biology — Posted on 2022-04-08

2836 Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export

Lim, S.; Liu, Y.; Rhie, B.-H.; Kim, C.; Ryu, H.-Y.; Ahn, S. H.

10.1101/2022.04.07.487427 — cell biology — Posted on 2022-04-08

2837 RNase H1 exists as phase-separated assemblies in association with elongating RNA Polymerase II during transcription

Das, R.; Dey, A.; Misra, H. S.; Uppal, S.

10.1101/2022.04.08.487625 — cell biology — Posted on 2022-04-08

2838 The impact of housing conditions on mesenchymal stromal/stem cell populations differ between adipose tissue and skeletal muscle

QUEMENER, A.; DESSAUGE, F.; PERRUCHOT, M.-H.; LE FLOC'H, N.; LOUVEAU, I.

10.1101/2021.06.08.447546 — cell biology — Posted on 2022-04-08

2839 Simulating semantic dementia in a brain-constrained model of action and object words learning

Efremov, A.; Kuptsova, A.; Wennekers, T.; Shtyrov, Y.; Garagnani, M.; Gutkin, B.

10.1101/2022.03.03.482066 — neuroscience — Posted on 2022-04-08

2840 Stabilizing brain-computer interfaces through alignment of latent dynamics

Karpowicz, B. M.; Ali, Y. H.; Wimalasena, L. N.; Sedler, A. R.; Keshtkaran, M. R.; Bodkin, K.; Ma, X.; Miller, L. E.; Pandarinath, C.

10.1101/2022.04.06.487388 — neuroscience — Posted on 2022-04-08

2841 Polycomb-mediated repression of paternal chromosomes maintains haploid dosage in diploid embryos of Marchantia

Montgomery, S. A.; Hisanaga, T.; Wang, N.; Axelsson, E.; Akimcheva, S.; Sramek, M.; Liu, C.; Berger, F.

10.1101/2022.02.04.477531 — molecular biology — Posted on 2022-04-08

2842 The maintenance of self-incompatibility: overdominance of inbreeding depression and S-linked genetic load

Schoen, D. J.; Baldwin, S. J.

10.1101/2022.03.24.485676 — evolutionary biology — Posted on 2022-04-08

2843 Topographic projection of retinal ganglion cell axons at single-cell precision underlies retinotopy in the mouse superior colliculus

Molotkov, D.; Boissonnet, T.; Asari, H.

10.1101/2022.03.25.485790 — neuroscience — Posted on 2022-04-08

2844 Multi-state Modeling of G-protein Coupled Receptors at Experimental Accuracy

Heo, L.; Feig, M.

10.1101/2021.11.26.470086 — biophysics — Posted on 2022-04-08

2845 LILAC: Enhanced actin imaging with an optogenetic Lifeact

Kroll, K. L.; French, A. R.; Sosnick, T. R.; Rock, R. S.

10.1101/2022.04.07.487416 — biophysics — Posted on 2022-04-08

2846 Reference genome-independent taxonomic profiling of microbiomes with mOTUs3

Ruscheweyh, H.-J.; Milanese, A.; Paoli, L.; Karcher, N.; Clayssen, Q.; Metzger, M. I.; Wirbel, J.; Bork, P.; Mende, D.; Zeller, G.; Sunagawa, S.

10.1101/2021.04.20.440600 — bioinformatics — Posted on 2022-04-08

2847 Mimicked synthetic ribosomal protein complex for benchmarking cross-linking mass spectrometry workflows

Matzinger, M.; Vasiu, A. D.; Madalinski, M.; Mueller, F.; Stanek, F.; Mechtler, K.

10.1101/2021.10.21.465295 — bioinformatics — Posted on 2022-04-08

2848 Prediction of quality-control degradation signals in yeast proteins

Johansson, K. E.; Mashahreh, B.; Hartmann-Petersen, R.; Ravid, T.; Lindorff-Larsen, K.

10.1101/2022.04.06.487301 — bioinformatics — Posted on 2022-04-08

2849 An End-to-End Deep Learning Speech Coding and Denoising Strategy for Cochlear Implants

Gajecki, T.; Nogueira, W.

10.1101/2021.11.04.467324 — bioengineering — Posted on 2022-04-08

2850 Assessment of AI-based Protein Structure Prediction for the NLRP3 Target

Yin, J.; Yu, J.; Lei, J.; Cui, W.; Satz, A. L.; Zhou, Y.; Feng, H.; Deng, J.; Su, W.; Kuai, L.

10.1101/2021.11.05.467381 — biochemistry — Posted on 2022-04-08

2851 Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site

Rennie, M. L.; Arkinson, C.; Chaugule, V. K.; Walden, H.

10.1101/2022.04.06.487267 — biochemistry — Posted on 2022-04-08

2852 Spatially resolved whole transcriptome profiling in human and mouse tissue using Digital Spatial Profiling

Zimmerman, S. M.; Fropf, R.; Kulasekara, B. R.; Griswold, M.; Appelbe, O.; Bahrami, A.; Boykin, R.; Buhr, D. L.; Fuhrman, K.; Hoang, M. L.; Huynh, Q.; Isgur, L.; Klock, A.; Kutchma, A.; Lasley, A. E.; Liang, Y.; McKay-Fleisch, J.; Nelson, J. S.; Nguyen, K.; Piazza, E.; Rininger, A.; Zollinger, D. R.; Rhodes, M.; Beechem, J. M.

10.1101/2021.09.29.462442 — genomics — Posted on 2022-04-08

2853 Holobiont Evolution: Population Theory for the Hologenome

Roughgarden, J.

10.1101/2020.04.10.036350 — evolutionary biology — Posted on 2022-04-08

2854 SyNPL: Synthetic Notch pluripotent cell lines to monitor and manipulate cell interactions in vitro and in vivo.

Malaguti, M.; Portero Migueles, R.; Annoh, J. A.; Sadurska, D.; Blin, G.; Lowell, S.

10.1101/2021.09.24.461672 — developmental biology — Posted on 2022-04-08

2855 Consequences of alanine-126 mutations in helix-3 on structure and functions of Rad6 E2 ubiquitin-conjugating enzymes

Shukla, P. K.; Sinha, D.; Leng, A. M.; Bissell, J. E.; Thatipamula, S.; Ganguly, R.; Skalicky, J. J.; Shrieve, D. C.; Chandrasekharan, M.

10.1101/2021.10.12.464121 — molecular biology — Posted on 2022-04-08

2856 Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag

Bartosovic, M.; Castelo-Branco, G.

10.1101/2022.03.08.483459 — molecular biology — Posted on 2022-04-08

2857 Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria is Governed by a Global Transcriptional Regulator NagR

Arzamasov, A. A.; Nakajima, A.; Sakanaka, M.; Ojima, M. N.; Katayama, T.; Rodionov, D. A.; Osterman, A. L.

10.1101/2022.04.06.487429 — microbiology — Posted on 2022-04-08

2858 The mitochondrial gene CMPK2 functions as a rheostat for macrophage homeostasis in inflammation

Arumugam, P.; Chauhan, M.; Rajeev, T.; Chakraborty, R.; Shankaran, D.; Ramalingam, S.; Gandotra, S.; Rao, V. K.

10.1101/2021.11.01.466732 — immunology — Posted on 2022-04-08

2859 Advanced paternal age diversifies individual trajectories of vocalization patterns in neonatal mice

Mai, L.; Inada, H.; Kimura, R.; Kanno, K.; Matsuda, T.; Tachibana, R. O.; Tucci, V.; Komaki, F.; Hiroi, N.; Osumi, N.

10.1101/738781 — neuroscience — Posted on 2022-04-08

2860 EEG Microstate Correlates of Emotion Dynamics and Stimulation Content during Video Watching

Hu, W.; Zhang, Z.; Zhao, H.; Zhang, L.; Li, L.; Huang, G.; Liang, Z.

10.1101/2021.10.09.463281 — neuroscience — Posted on 2022-04-08

2861 The endoplasmic reticulum in perisynaptic astrocytic processes: shape, distribution and effect on calcium activity

Denizot, A.; Castillo, M. F. V.; Puchenkov, P.; Cali, C.; De Schutter, E.

10.1101/2022.02.28.482292 — neuroscience — Posted on 2022-04-08

2862 Modulation of the renin-angiotensin system inhibits memory advantage for negative emotional material via decreasing hippocampus activation and its coupling with the amygdala

Xu, T.; Zhou, X.; Jiao, G.; Zeng, Y.; Zhao, W.; Li, J.; Yu, F.; Zhou, F.; Yao, S.; Becker, B.

10.1101/2021.08.14.456361 — neuroscience — Posted on 2022-04-08

2863 Detection of Dugbe virus from ticks in Ghana

Addae, C. A.; Wiley, M.; Pratt, C.; Koehler, J. W.; Addo, S. O.; Mosore, M.; Yeboah, C.; Agbodzi, B.; Ladzekpo, D.; Tagoe, J. A.; Behene, E.; Adrah, I.; Defeamekpo, C.; Quaye, O.; Letizia, A.; Nimo-Paintsil, S.; Arimoto, H.; Diclaro, J. W.; Dadzie, S.

10.1101/2022.04.04.486928 — scientific communication and education — Posted on 2022-04-08

2864 Impaired iron recycling from erythrocytes is an early iron-dependent hallmark of aging

Slusarczyk, P.; Mandal, P. K.; Zurawska, G.; Niklewicz, M.; Kumari Chouhan, K.; Macias, M.; Szybinska, A.; Cybulska, M.; Krawczyk, O.; Herman, S.; Mikula, M.; Serwa, R.; Lenartowicz, M.; Pokrzywa, W.; Mleczko-Sanecka, K.

10.1101/2022.01.16.476518 — physiology — Posted on 2022-04-08

2865 Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

Su, H.; Yang, F.; Fu, R.; Trinh, B.; Sun, N.; Liu, J.; Kumar, A.; Baglieri, J.; Siruno, J.; Dozier, S.; Nair, A.; Filliol, A.; Rosenthal, S. B.; Santini, J.; Metallo, C. M.; Molina, A.; Schwabe, R. F.; Lowy, A. M.; Brenner, D.; Sun, B.; Karin, M.

10.1101/2022.04.02.486837 — cancer biology — Posted on 2022-04-08

2866 High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation

Laine, R. F.; Heil, H. S.; Coelho, S.; Nixon-Abell, J.; Jimenez, A.; Galgani, T.; Stubb, A.; Follain, G.; Culley, S.; Jacquemet, G.; Hajj, B.; Leterrier, C.; Henriques, R.

10.1101/2022.04.07.487490 — biophysics — Posted on 2022-04-08

2867 Material-mediated histogenesis using mechano-chemically microstructured cell niches

Newman, P. L. H.; Yip, Q.; Osteil, P.; Anderson, T. A.; Sun, J. Q. J.; Kempe, D.; Biro, M.; Shin, J.-W.; Tam, P. P. L.; Zreiqat, H.

10.1101/2021.02.10.430691 — bioengineering — Posted on 2022-04-08

2868 Antihypertensive effect of brain-targeted mechanical intervention with passive head motion

Murase, S.; Sakitani, N.; Maekawa, T.; Yoshino, D.; Takano, K.; Konno, A.; Hirai, H.; Saito, T.; Tanaka, S.; Shinohara, K.; Kishi, T.; Yoshikawa, Y.; Sakai, T.; Ayaori, M.; Inanami, H.; Tomiyasu, K.; Takashima, A.; Ogata, T.; Tsuchimochi, H.; Sato, S.; Saito, S.; Yoshino, K.; Matsuura, Y.; Funamoto, K.; Ochi, H.; Shinohara, M.; Nagao, M.; Sawada, Y.

10.1101/2020.09.21.305706 — bioengineering — Posted on 2022-04-08

2869 ARP2/3 complex associates with peroxisomes to participate in pexophagy in plants

Martinek, J.; Cifrova, P.; Vosolsobe, S.; Krtkova, J.; Sikorova, L.; Malinska, K.; Mauerova, Z.; Leaves, I.; Sparkes, I.; Schwarzerova, K.

10.1101/2022.04.07.487451 — cell biology — Posted on 2022-04-08

2870 Pharmacological inhibition of titan-like cells formation suggests that accumulation of endogenous free radicals that correlate with mitochondrial changes are required to induce this transition in Cryptococcus neoformans

Garcia-Barbazan, I.; Garcia-Rodas, R.; Sachse, M.; Luque, D.; Megias, D.; Zaragoza, O.

10.1101/2022.04.06.487428 — microbiology — Posted on 2022-04-08

2871 An overlapped natural antisense lncRNA FCER1A-AS controls anaphylactic reaction by promoting FcϵRIα expression

Tang, R.; Yin, L.; Yao, L.; CHEN, X.-P.

10.1101/2022.04.05.487139 — immunology — Posted on 2022-04-08

2872 A critical developmental interval of coupling axon branching to synaptic degradation during neural circuit formation

Dutta, S.; Linneweber, G.; Andriatsilavo, M.; Hiesinger, P. R.; Hassan, B. A.

10.1101/2022.04.06.486606 — neuroscience — Posted on 2022-04-08

2873 Pan-genome evolution and its association with divergence of metabolic functions in Bifidobacterium genus

Deb, S.

10.1101/2022.04.05.487182 — genomics — Posted on 2022-04-08

2874 Comprehensive multiomic profiling of somatic mutations in malformations of cortical development

10.1101/2022.04.07.487401 — genetics — Posted on 2022-04-08

2875 Development of the adult-like larval stomach of Lepidobatrachus laevis

Austiff, J. K.; Hanken, J.

10.1101/2022.04.05.487172 — developmental biology — Posted on 2022-04-08

2876 Dyslexia associated gene, KIAA0319, regulates cell cycle during human neuroepithelium development

Paniagua, S.; Cakir, B.; Hu, Y.; Kiral, F. R.; Tanaka, Y.; Xiang, Y.; Patterson, B.; Gruen, J. R.; Park, I.-H.

10.1101/2022.04.07.487504 — developmental biology — Posted on 2022-04-08

2877 COP I and II dependent trafficking controls ER-associated degradation

Ogen-Shtern, N.; Chang, C.; Saad, H.; Mazkereth, N.; Patel, C.; Shenkman, M.; Lederkremer, G. Z.

10.1101/2022.04.07.487480 — cell biology — Posted on 2022-04-08

2878 Probing the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy

Biswas, P.; Ray, D.; Jana, S.; Das, J.; Sinha, B.; Sinha, D.

10.1101/2022.04.07.487477 — cell biology — Posted on 2022-04-08

2879 A salt bridge mediated resistance mechanism to FtsZ inhibitor PC190723 revealed by a single step cell-based screen

Sharma, A. K.; Poddar, S. M.; Chakraborty, J.; Nayak, B. S.; Kalathil, S.; Mitra, N.; Gayathri, P.; SRINIVASAN, R.

10.1101/2022.04.06.487355 — cell biology — Posted on 2022-04-08

2880 A method for stabilising the XX karyotype in female mESC cultures

Keniry, A.; Jansz, N.; Hickey, P. F.; Breslin, K.; Iminitoff, M.; Beck, T.; Ritchie, M. E.; Blewitt, M. E.

10.1101/2022.04.07.487567 — cell biology — Posted on 2022-04-08

2881 Systems modelling of TGF-β/Hippo signalling crosstalk uncovers molecular switches that coordinate YAP transcriptional complexes

Ghomlaghi, M.; Theocharous, M.; Shin, S.; O'Neill, E.; Nguyen, L. K.

10.1101/2022.04.06.487403 — cell biology — Posted on 2022-04-08

2882 Circadian clock control of MRTF-SRF signaling suppresses beige adipocyte thermogenic recruitment

Xiong, X.; Li, W.; Liu, R.; Saha, P. K.; Yechoor, V.; Ma, K.

10.1101/2022.04.06.487359 — cell biology — Posted on 2022-04-08

2883 Rapid Rerouting of Myosin Traffic at the T Cell Immunological Synapse

Maka, R.; Plewa, N.; Cichon, U.; Krysztofiak, K.; Rokicka, J. J.; Rock, R. S.

10.1101/2022.04.06.487340 — cell biology — Posted on 2022-04-08

2884 Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs

Kastan, N. R.; Oak, S.; Liang, R.; Baxt, L.; Myers, R. W.; Ginn, J.; Liverton, N.; Huggins, D. J.; Pichardo, J.; Paul, M.; Carroll, T. S.; Nagiel, A.; Gnedeva, K.; Hudspeth, A. J.

10.1101/2022.04.07.487521 — cell biology — Posted on 2022-04-08

2885 Visualizing Molecular Interactions that Determine Assembly of a Bullet-Shaped Vesicular Stomatitis Virus Particle

Jenni, S.; Horwitz, J. A.; Bloyet, L.-M.; Whelan, S. J. P.; Harrison, S. C.

10.1101/2022.04.07.487545 — molecular biology — Posted on 2022-04-08

2886 CyTOF-Lec: Single-cell glycomics analysis reveals glycan features defining cells differentially susceptible to HIV

Ma, T.; McGregor, M.; Giron, L.; Xie, G.; George, A.; Abdel-Mohsen, M.; Roan, N. R.

10.1101/2022.04.06.487312 — immunology — Posted on 2022-04-08

2887 Neuronopathic GBA1 L444P mutation accelerates glucosylsphingosine levels and formation of hippocampal alpha-synuclein inclusions

Mahoney, C. L.; Viswanathan, M.; Russell, D.; Curtiss, R. A. C.; Freire, J.; Bobba, S. S.; Coyle, S. D.; Kandebo, M.; Yao, L.; Wan, B.-L.; Hatcher, N. G.; Smith, S. M.; Marcus, J. N.; Volpicelli-Daley, L. A.

10.1101/2022.04.07.487391 — neuroscience — Posted on 2022-04-08

2888 Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies

Bohr, F.; Bohr, S. S. R.; Mishra, N. K.; Foutel, N. S. G.; Pinholt, H. D.; Wu, S.; Nirlsen, E. M.; Zhang, M.; Kjaergaard, M.; Jensen, K. J.; Hatzakis, N. S.

10.1101/2022.04.06.487286 — biophysics — Posted on 2022-04-08

2889 A consensus view on the folding mechanism of protein G, L and their mutants

Chang, L.; Perez, A.

10.1101/2022.04.07.487494 — biophysics — Posted on 2022-04-08

2890 Restricting α-Synuclein Transport into Mitochondria by Inhibition of α-Synuclein-VDAC Complexation as a Potential Therapeutic Target for Parkinson's Disease Treatment

Rajendran, M.; Queralt-Martin, M.; Gurnev, P. A.; Rosencrans, W. M.; Rovini, A.; Jacobs, D.; Abrantes, K.; Hoogerheide, D. P.; Bezrukov, S. M.; Rostovtseva, T. K.

10.1101/2022.04.07.487541 — biophysics — Posted on 2022-04-08

2891 Structural insights into sodium/iodide symporter (NIS) substrate binding and specificity

Ravera, S.; Nicola, J. P.; Salazar de Simone, G.; Sigworth, F. J.; Karakas, E.; Amzel, L. M.; Bianchet, M. A.; Carrasco, N.

10.1101/2022.04.07.487502 — biophysics — Posted on 2022-04-08

2892 Prediction of quality-control degradation signals in yeast proteins

Johansson, K. E.; Mashahreh, B.; Hartmann-Petersen, R.; Ravid, T.; Lindorff-Larsen, K.

10.1101/2022.04.06.487301 — bioinformatics — Posted on 2022-04-08

2893 The impact of AlphaFold on experimental structure solution

Edich, M.; Briggs, D. C.; Kippes, O.; Gao, Y.; Thorn, A.

10.1101/2022.04.07.487522 — bioinformatics — Posted on 2022-04-08

2894 A generic framework for hierarchical de novo protein design

Harteveld, Z.; Bonet, J.; Rosset, S.; Yang, C.; Sesterhenn, F.; Correia, B. E.

10.1101/2022.04.07.487481 — bioinformatics — Posted on 2022-04-08

2895 Experimental evolution of phosphomannomutase-deficient yeast reveals compensatory mutations in a phosphoglucomutase

Vignogna, R. C.; Allocca, M.; Monticelli, M.; Norris, J. W.; Steet, R.; Andreotti, G.; Perlstein, E. O.; Lang, G. I.

10.1101/2022.04.06.487342 — evolutionary biology — Posted on 2022-04-08

2896 The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan

Meras, I.; Chotard, L.; Liontis, T.; Ratemi, Z.; Wiles, B.; Seo, J. H.; Van Raamsdonk, J. M.; Rocheleau, C. E.

10.1101/2021.06.04.447106 — cell biology — Posted on 2022-04-08

2897 Intestinal microbiota dysbiosis and liver metabolomic changes during brain death

Wang, P.; Tao, R.; Guo, W.; Li, T.; Wang, Y.

10.1101/2022.04.07.487534 — microbiology — Posted on 2022-04-07

2898 Trypanosoma cruzi PARP is enriched in the nucleolus and is present in a thread connecting nuclei during mitosis.

KEVORKIAN, M. L.; VILCHEZ LARREA, S. C.; FERNANDEZ, S. H.

10.1101/2022.04.07.487537 — microbiology — Posted on 2022-04-07

2899 Biogeography and taxonomy of the Hemileuca maia-nevadensis Stretch species complex (Lepidoptera: Saturniidae): insights to the midcontinental populations

Schmidt, C.

10.1101/2022.04.07.487535 — zoology — Posted on 2022-04-07

2900 Modeling protected species distributions and habitats to inform siting and management of pioneering ocean industries: A case study for Gulf of Mexico aquaculture

Farmer, N. A.; Powell, J. R.; Morris, J. A.; Soldevilla, M. S.; Wickliffe, L. C.; Jossart, J. A.; MacKay, J. K.; Randall, A. L.; Bath, G. E.; Ruvelas, P.; Gray, L.; Lee, J.; Piniak, W.; Garrison, L. P.; Hardy, R.; Hart, K. M.; Sasso, C. R.; Stokes, L.; Riley, K. L.

10.1101/2022.04.07.487536 — scientific communication and education — Posted on 2022-04-07

2901 The concordance of signals based on irregular incremental lines in the human tooth cementum with documented pregnancies: Results from a systematic approach

Mani-Caplazi, G.; Vach, W.; Wittwer-Backofen, U.; Hotz, G.

10.1101/2022.04.07.487538 — physiology — Posted on 2022-04-07

2902 The Gene Knockout of Angiotensin II Type 1a Receptor Improves High-fat Diet-Induced Obesity in rat via Promoting Adipose Lipolysis

Li, A.; Shi, W.; Wang, J.; Wang, X.; Zhang, Y.; Lei, Z.; Jiao, X.-y.

10.1101/2022.04.07.487533 — physiology — Posted on 2022-04-07

2903 The Statistical Trends of Protein Evolution: A Lesson from AlphaFold Database

Tang, Q.-Y.; Ren, W.; Wang, J.; Kaneko, K.

10.1101/2022.04.07.487447 — biophysics — Posted on 2022-04-07

2904 Plant N-glycan breakdown by human gut Bacteroides

Crouch, L. I.; Urbanowicz, P. A.; Basle, A.; Cai, Z.-P.; Liu, L.; Voglmeir, J.; Melo Diaz, J. M.; Benedict, S. T.; Spencer, D. I.; Bolam, D. N.

10.1101/2022.04.07.487459 — biochemistry — Posted on 2022-04-07

2905 The Streptococcus pyogenes hyaluronic acid capsule promotes experimental nasal and skin infection by preventing neutrophil-mediated clearance

Hurst, J. R.; Shannon, B. A.; Craig, H. C.; Tuffs, S. W.; McCormick, J. K.

10.1101/2022.04.07.487539 — microbiology — Posted on 2022-04-07

2906 Secreted dengue virus NS1 is predominantly dimeric and in complex with high-density lipoprotein

Chew, B. L. A.; Ngoh, A. Q.; Phoo, W. W.; Chan, W. K. K.; Zheng, S.; Lim, S. S.; Weng, M. J. G.; Watanabe, S.; Choy, M. M.; Low, G. H. J.; Ooi, E. E.; SOBOTA, R. M.; Vasudevan, S. G.; Luo, D.

10.1101/2022.04.06.487425 — microbiology — Posted on 2022-04-07

2907 The phosphatase Bph and peptidyl-prolyl isomerase PrsA are required for gelatinase expression and activity in Enterococcus faecalis

Willett, J.; Robertson, E. B.; Dunny, G. M.

10.1101/2022.04.06.487426 — microbiology — Posted on 2022-04-07

2908 Dissecting the conformational complexity and flipping mechanism of bacterial heme transport.

Wu, D.; Mehdipour, A. R.; Finke, F.; Goojani, H. G.; Groh, R. R.; Grund, T. N.; Reichhart, T. M.; Zimmermann, R.; Welsch, S.; Bald, D.; Shepherd, M.; Hummer, G.; Safarian, S.

10.1101/2022.04.07.487047 — microbiology — Posted on 2022-04-07

2909 A transcriptional network required for Toxoplasma gondii tissue cyst formation is dispensable for long-term persistence

Sokol Borrelli, S. L.; Reilly, S. M.; Sharp, K. G.; Cabo, L. F.; Alrubaye, H. S.; di Genova, B. M.; Boyle, J. P. P.

10.1101/2022.04.06.487408 — microbiology — Posted on 2022-04-07

2910 Extended functional connectivity of convergent structural alterations among individuals with PTSD: A neuroimaging meta-analysis

Pankey, B. S.; Riedel, M. C.; Cowan, I.; Bartley, J. E.; Pintos Lobo, R.; Hill-Bowen, L. D.; Salo, T.; Musser, E. D.; Sutherland, M. T.; Laird, A. R.

10.1101/2022.04.07.487478 — neuroscience — Posted on 2022-04-07

2911 Streptococcus Pneumoniae Promotes Lung Tumorigenesis by Activating PI3K/AKT and NF-kB Pathways via Binding PspC to PAFR

Li, N.; Zhou, H.; Holden, V. K.; Deepak, J.; Todd, N. w.; jiang, f.

10.1101/2022.04.07.487465 — cancer biology — Posted on 2022-04-07

2912 AGC: Compact representation of assembled genomes

Deorowicz, S.; Danek, A.; Li, H.

10.1101/2022.04.07.487441 — bioinformatics — Posted on 2022-04-07

2913 CRISPRedict: The case for simple and interpretable efficiency prediction for CRISPR-Cas9 gene editing

Konstantakos, V.; Nentidis, A.; Krithara, A.; Paliouras, G.

10.1101/2022.04.07.486362 — bioinformatics — Posted on 2022-04-07

2914 Extracellular Vesicle Antibody Microarray for Multiplexed Inner and Outer Protein Analysis

Martel, R.; Shen, M. L.; DeCorwin-Martin, P.; de Araujo, L. O. F.; Juncker, D.

10.1101/2022.04.05.487234 — bioengineering — Posted on 2022-04-07

2915 Computational Design of Two New Vitamin K Epoxide Reductase Inhibitors

Cao, C.; Adhikari, S.; Huang, P.; Siegel, J. B.

10.1101/2022.04.06.487400 — biochemistry — Posted on 2022-04-07

2916 A multiscale atlas of the molecular and cellular architecture of the human kidney

Neumann, E. K.; Patterson, N. H.; Tideman, L. E. M.; Migas, L. G.; Colley, M. E.; Farrow, M. A.; Allen, J. L.; Rivera, E. S.; Rmer, C. E.; Yang, H.; Brewer, M.; Sharman, K.; Harris, R. C.; Fogo, A. B.; Gutierrez, D. B.; de Caestecker, M. P.; Caprioli, R. M.; Van de Plas, R.; Spraggins, J. M.

10.1101/2022.04.07.487155 — biochemistry — Posted on 2022-04-07

2917 The structure of the F420-dependent sulfite-detoxifying enzyme from Methanococcales reveals a prototypical sulfite-reductase with assimilatory traits.

Jespersen, M.; Pierik, A. J.; Wagner, T.

10.1101/2022.04.07.487323 — biochemistry — Posted on 2022-04-07

2918 Biochemical characterization of AniA from Neisseria gonorrhoeae

Barreiro, D. S.; Oliveira, R. N. S.; Pauleta, S. R.

10.1101/2022.04.07.487406 — biochemistry — Posted on 2022-04-07

2919 Novel Antibody Interfaces Revealed Through Structural Mining

Yin, Y.; Romei, M.; Sankar, K.; Pal, L. R.; Hoi, K. H.; Yang, Y.; Leonard, B.; Boenig, G. D. L.; Kumar, N.; Matsumoto, M.; Payandeh, J.; Harris, S. F.; Moult, J.; Lazar, G. A.

10.1101/2022.04.06.487381 — biochemistry — Posted on 2022-04-07

2920 Demographic expansions and the emergence of host specialization in genetically distinct strains of the tick-transmitted bacterium Anaplasma phagocytophilum

Aardema, M. L.; Bates, N. V.; Archer, Q. E.; von Loewenich, F. D.

10.1101/2022.04.05.487247 — evolutionary biology — Posted on 2022-04-07

2921 Detecting macroevolutionary genotype-phenotype associations using error-corrected rates of protein convergence

Fukushima, K.; Pollock, D. D.

10.1101/2022.04.06.487346 — evolutionary biology — Posted on 2022-04-07

2922 Genotypic sex shapes maternal care in the African Pygmy mouse, Mus minutoides

Heitzmann, L. D.; Challe, M.; Perez, J.; Castell, L.; Galibert, E.; Martin, A.; Valjent, E.; Veyrunes, F.

10.1101/2022.04.05.487174 — evolutionary biology — Posted on 2022-04-07

2923 Entropy change due to selection in replicator and recombinator systems with randomly chosen interaction matrix values

Tiefenbrunner, W.

10.1101/2022.04.05.487241 — evolutionary biology — Posted on 2022-04-07

2924 Recycling of uridylated mRNAs in starfish embryos

Yamazaki, H.; Furuichi, M.; Katagiri, M.; Kajitani, R.; Itoh, T.; Chiba, K.

10.1101/2022.04.07.487435 — molecular biology — Posted on 2022-04-07

2925 Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney

Liu, S.; Xia, X.; Zhen, J.; Li, Z.; Zhou, H.

10.1101/2022.04.06.487412 — molecular biology — Posted on 2022-04-07

2926 Niclosamide targets macrophages to rescue the disrupted peritoneal homeostasis in endometriosis

Zhao, L.; Shi, M.; Winuthayanon, S.; MacLean, J. A.; Hayashi, K.

10.1101/2022.04.05.487220 — molecular biology — Posted on 2022-04-07

2927 Neutrophil IL-1β secretion induced by ExoS expressing Pseudomonas aeruginosa is dependent on NLRP3 and Gasdermin D

Minns, M.; Lima, T.; Liboro, K.; Abbondante, S.; Marshall, M.; Rietsch, A.; Dubyak, G.; Pearlman, E.

10.1101/2022.04.07.487503 — microbiology — Posted on 2022-04-07

2928 The production of diverse brGDGTs by an Acidobacterium allows a direct test of temperature and pH controls on their distribution

Chen, Y.; Zheng, F.; Yang, H.; Yang, W.; Wu, R.; Liu, X.; Liang, H.; Chen, H.; Pei, H.; Zhang, C.; Pancost, R. D.; Zeng, Z.

10.1101/2022.04.07.487437 — microbiology — Posted on 2022-04-07

2929 Distinct cohorts of Aspergillus fumigatus transcription factors are required for epithelial damage occurring via contact- or soluble effector-mediated mechanisms

Rahman, S.; van Rhijn, N.; Papastamoulis, P.; Thomson, D. D.; Carter, Z.; Gregson, L.; Fortune-Grant, R.; Rattray, M.; Bromley, M. J.; Bignell, E.

10.1101/2022.04.07.487466 — microbiology — Posted on 2022-04-07

2930 Antibiotic persistence of Brucella abortus in its protective intracellular niche

Mode, S.; Ketterer, M.; Quebatte, M.; Dehio, C.

10.1101/2022.04.07.487436 — microbiology — Posted on 2022-04-07

2931 Collateral sensitivity as a strategy to suppress resistance emergence: the challenge of diverse evolutionary pathways

Mandt, R. E. K.; Luth, M. R.; Tye, M. A.; Mazitschek, R.; Ottilie, S.; Winzeler, E. A.; Lafuente-Monasterio, M. J.; Gamo, F. J.; Wirth, D. F.; Lukens, A. K.

10.1101/2022.04.07.486819 — microbiology — Posted on 2022-04-07

2932 Mechanical morphotype switching as an adaptive response in mycobacteria

Eskandarian, H. A.; Chen, Y.-X.; Toniolo, C.; Belardinelli, J. M.; Palcekova, Z.; Ashby, P. D.; Fantner, G. E.; Jackson, M.; McKinney, J. D.; Javid, B.

10.1101/2022.04.06.487411 — microbiology — Posted on 2022-04-07

2933 Characterizing a New Fluorescent Protein for Low Limit of Detection Sensing in the Cell-Free System

Copeland, C. E.; Kim, J.; Copeland, P. L.; Heitmeier, C. J.; Kwon, Y.-C.

10.1101/2022.04.06.487419 — synthetic biology — Posted on 2022-04-07

2934 Dynamic interaction of BcsD subunit in type I bacterial cellulose synthase

Kondo, T.; Nakamura, Y.; Nojima, S.; Yao, M.; Imai, T.

10.1101/2022.03.27.485962 — biochemistry — Posted on 2022-04-07

2935 Structure-based discovery of a non-canonical prototype long-chain monoacylglycerol lipase through an endogenous catalysis intermediate complex

Pinotsis, N.; Krüger, A.; Tomas, N.; Chatziefthymiou, S. D.; Litz, C.; Mortensen, S. A.; Daffé, M.; Marrakchi, H.; Antranikian, G.; Wilmanns, M.

10.1101/2022.04.07.487456 — biochemistry — Posted on 2022-04-07

2936 Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

Fiddler, J. L.; Blum, J. E.; Castillo, L. F.; Thalacker-Mercer, A. E.; Field, M. S.

10.1101/2022.04.07.487511 — biochemistry — Posted on 2022-04-07

2937 Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination

Lemonidis, K.; Rennie, M. L.; Arkinson, C.; Chaugule, V. K.; Clarke, M.; Streetley, J.; Walden, H.

10.1101/2022.04.07.487446 — biochemistry — Posted on 2022-04-07

2938 A full spectrum PNGase activity analysis of R328 mutations on NGLY1

Yuan, S.; Chen, Y.; Zou, L.; Lu, X.; Liu, R.; Zhang, S.; CHEN, L.; Sun, G.

10.1101/2022.04.07.487431 — biochemistry — Posted on 2022-04-07

2939 Phylogenetic and Ecological Trends in Specialization: Disentangling the Drivers of Ectoparasite Host Specificity

Brown, A. M.; Speer, K.; Tiexeira, T.; Clare, E.; Simmons, N. B.; Balbuena, J. A.; Dick, C.; Dittmar, K.; Perkins, S.

10.1101/2022.04.06.487338 — ecology — Posted on 2022-04-07

2940 Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria is Governed by a Global Transcriptional Regulator NagR

Arzamasov, A. A.; Nakajima, A.; Sakanaka, M.; Ojima, M. N.; Katayama, T.; Rodionov, D. A.; Osterman, A. L.

10.1101/2022.04.06.487429 — microbiology — Posted on 2022-04-07

2941 A Lysozyme Murein Hydrolase with Broad-spectrum Antibacterial Activity from Enterobacter Phage myPSH1140

Nachimuthu, R.; Manohar, P.; Eniyan, K.; Archana, L.; Athira, S.; Loh, B.; Ma, L.; Leptihn, S.

10.1101/2022.04.06.487332 — microbiology — Posted on 2022-04-07

2942 Deposit-feeding worms control subsurface ecosystem functioning in intertidal sediment with strong physical forcing

Deng, L.; Meile, C.; Fiskal, A.; Boelsterli, D.; Han, X.; Gajendra, N.; Dubois, N.; Bernasconi, S. M.; Lever, M. A.

10.1101/2022.04.06.487375 — microbiology — Posted on 2022-04-07

2943 Constricted migration is associated with stable 3D genome structure differences in cancer cells

Golloshi, R.; Playter, C.; Freeman, T. F.; Das, P.; Raines, T. I.; Garretson, J. H.; Thurston, D. M.; McCord, R. P.

10.1101/856583 — systems biology — Posted on 2022-04-07

2944 BioCRNpyler: Compiling Chemical Reaction Networks from Biomolecular Parts in Diverse Contexts

Poole, W.; Pandey, A.; Tuza, Z.; Shur, A.; Murray, R. M.

10.1101/2020.08.02.233478 — synthetic biology — Posted on 2022-04-07

2945 The MyLo CRISPR-Cas9 Toolkit: A Markerless Yeast Localization and Overexpression CRISPR-Cas9 Toolkit

Bean, B. D.; Whiteway, M.; Martin, V. J.

10.1101/2021.12.15.472800 — synthetic biology — Posted on 2022-04-07

2946 Spatiotemporal analysis of glioma heterogeneity reveals Col1A1 as an actionable 1 target to disrupt tumor mesenchymal differentiation, invasion and malignancy

Comba, A.; Faisal, S. M.; Dunn, P. J.; Argento, A. E.; Hollon, T. C.; Al-Holou, W.; Varela, M. L.; Zamler, D. B.; Quass, G. L.; Apostolides, P. F.; Abel, C.; Brown, C. E.; Kish, P. E.; Kahana, A.; Kleer, C. G.; Motsch, S.; Castro, M. G.; Lowenstein, P. R.

10.1101/2020.12.01.404970 — cancer biology — Posted on 2022-04-07

2947 amica: an interactive and user-friendly web-platform for the analysis of proteomics data

Didusch, S.; Madern, M.; Hartl, M.; Baccarini, M.

10.1101/2021.11.23.466958 — bioinformatics — Posted on 2022-04-07

2948 Centrosomal Enrichment and Proteasomal Degradation of SYS-1/-β-catenin Requires the Microtubule Motor Dynein

Thompson, J. W.; Valdes Michel, M. F.; Phillips, B. T.

10.1101/2021.11.10.468136 — cell biology — Posted on 2022-04-07

2949 Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques

Sureshchandra, S.; Chan, C. N.; Robino, J. J.; Parmelee, L. K.; Nash, M. J.; Wesolowski, S. R.; Pietras, E. M.; Friedman, J. E.; Takahashi, D.; Shen, W.; Hennebold, J. D.; Goldman, D.; Packwood, W.; Lindner, J. R.; Roberts, C. T.; Burwitz, B. J.; Messaoudi, I.; Varlamov, O.

10.1101/2021.04.26.441556 — immunology — Posted on 2022-04-07

2950 Individual differences in late positive potential amplitude and theta power predict cue-induced eating

Gibney, K.; Kypriotakis, G.; Versace, F.

10.1101/2022.03.28.485549 — neuroscience — Posted on 2022-04-07

2951 Spatial and Texture Analysis of Root System Distribution with Earth Mover's Distance (STARSEED)

Peeples, J.; Xu, W.; Gloaguen, R.; Rowland, D.; Zare, A.; Brym, Z.

10.1101/2021.08.31.458446 — plant biology — Posted on 2022-04-07

2952 A Novel Chronic in vivo Oral Cadmium Exposure-Washout Mouse Model for Studying Cadmium Toxicity and Complex Diabetogenic Effects

Wong, W. P. S.; Wang, J. C.; Meyers, M. S.; Wang, N. J.; Sponenburg, R. A.; Allen, N. B.; Edwards, J. E.; El Muayed, M.

10.1101/2022.02.21.481351 — pharmacology and toxicology — Posted on 2022-04-07

2953 CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of KRAS mutant cancers

Basu, S.; Luke, B.; Karim, B.; Martin, N.; Lockett, S.; Das, S.; Andresson, T.; Saylor, K.; Kozlov, S.; Bassel, L.; Esposito, D.; Johnson, P. F.

10.1101/2022.04.05.487175 — cancer biology — Posted on 2022-04-07

2954 Distinct evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates identify important host determinants of COVID-19

Cariou, M.; Picard, L.; Gueguen, L.; Jacquet, S.; Cimarelli, A.; Fregoso, O. I.; Molaro, A.; Navratil, V.; Etienne, L.

10.1101/2022.04.07.487460 — evolutionary biology — Posted on 2022-04-07

2955 Antibody Resistance of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2 and BA.3 Sub-lineages

Ai, J.; Wang, X.; He, X.; Zhao, X.; Zhang, Y.; Jiang, Y.; Li, M.; Cui, Y.; Chen, Y.; Qiao, R.; Li, L.; Yang, L.; Li, Y.; Hu, Z.; Zhang, W.; Wang, P.

10.1101/2022.04.07.487489 — microbiology — Posted on 2022-04-07

2956 Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits mucosal immunity and prevents SARS CoV-2 infection and pathology

Shamseldin, M. M.; Zani, A.; Kenney, A.; Evans, J.; Zeng, C.; Read, K. A.; Caution, K.; Hall, J. M.; Brown, J. M.; Gunsch, G.; Corps, K. N.; Chaitwatponsakom, S.; KC, M.; Lu, M.; Deora, R.; Peeples, M. E.; Li, J.; Oestreich, K. J.; Liu, S.-L.; Yount, J. S.; Dubey, P.

10.1101/2022.04.06.487394 — immunology — Posted on 2022-04-07

2957 Canonical Strigolactones Are Not the Tillering-Inhibitory Hormone but Rhizospheric Signals in Rice

Ito, S.; Braguy, J.; Wang, J. Y.; Yoda, A.; Fiorilli, V.; Takahashi, I.; Jamil, M.; Felemban, A.; Miyazaki, S.; Mazzarella, T.; Shinozawa, A.; Balakrishna, A.; Berqdar, L.; Rajan, C.; Ali, S.; Haider, I.; Sasaki, Y.; Yajima, S.; Akiyama, K.; Lanfranco, L.; Zurbriggen, M. D.; Nomura, T.; Asami, T.; Al-Babili, S.

10.1101/2022.04.05.487102 — plant biology — Posted on 2022-04-07

2958 Membrane interactions of mitochondrial lipid transfer proteins

Sadeqi, F.; Stroh, K.; Vache, M.; Riedel, D.; Janshoff, A.; Risselada, H. J.; Meinecke, M.

10.1101/2022.04.05.487160 — biophysics — Posted on 2022-04-07

2959 Efficient Permutation-based Genome-wide Association Studies for Normal and Skewed Phenotypic Distributions

John, M.; Ankenbrand, M. J.; Artmann, C.; Freudenthal, J. A.; Korte, A.; Grimm, D. G.

10.1101/2022.04.05.487185 — bioinformatics — Posted on 2022-04-07

2960 Bumblebees retrieve only the ordinal ranking of foraging options when comparing memories obtained in distinct settings

Solvi, C.; Zhou, Y.; Roper, M.; Feng, Y.; Sun, L.; Reid, R.; Chittka, L.; Barron, A. B.; Peng, F.

10.1101/2022.04.05.487177 — animal behavior and cognition — Posted on 2022-04-07

2961 Architectural experience: clarifying its central components and their relation to core affect with a set of first-person-view videos

Gregorians, L.; Velasco, P. F.; Zisch, F.; Spiers, H. J.

10.1101/2022.04.05.487021 — animal behavior and cognition — Posted on 2022-04-07

2962 Comparative genomics of Minnesotan barley-infecting Xanthomonas translucens shows overall genomic similarity but virulence factor diversity

Heiden, N.; Roman-Reyna, V.; Curland, R. D.; Dill-Macky, R.; Jacobs, J. M.

10.1101/2022.04.05.487151 — genomics — Posted on 2022-04-07

2963 Reduced injury risk links sociality to survival in a group-living primate

Pavez-Fox, M. A.; Kimock, C. M.; Rivera-Barreto, N.; Negron-Del Valle, J. E.; Phillips, D.; Ruiz-Lambides, A.; Snyder-Mackler, N.; Higham, J. P.; Siracusa, E. R.; Brent, L. J. N.

10.1101/2022.04.05.487140 — evolutionary biology — Posted on 2022-04-07

2964 The net-like heterotrophic amoeba Leukarachnion salinum sp. nov. (Ochrophyta, Stramenopiles) has a cryptic plastid

Jaske, K.; Barcyte, D.; Panek, T.; Sevcikova, T.; Eliasova, A.; Elias, M.

10.1101/2022.04.05.487141 — evolutionary biology — Posted on 2022-04-07

2965 Fragmented habitat compensates for the adverse effects of genetic bottleneck

Löytynoja, A.; Rastas, P.; Valtonen, M.; Kammonen, J.; Holm, L.; Paulin, L.; Jernvall, J.; Auvinen, P.

10.1101/2022.04.05.487133 — evolutionary biology — Posted on 2022-04-07

2966 Kidins220 promotes thymic iNKT cell development by reducing TCR signals, but enhances TCR signals in splenic iNKT cells

Herr, L. A.; Fiala, G. J.; Schaffer, A.-M.; Raute, K.; Velasco Cardenas, R. M.-H.; Hummel, J. F.; Ebert, K.; Tanriver, Y.; Minguet, S.; Schamel, W. W.

10.1101/2022.04.05.487104 — immunology — Posted on 2022-04-07

2967 Zebrafish Galectin 3 binding protein (Lgals3bp) is the target antigen of the microglial 4C4 monoclonal antibody

Rovira, M.; Montanari, A.; Hammou, L.; Chomette, L.; Miserocchi, M.; Pozo, J.; Imbault, V.; Bisteau, X.; Wittamer, V.

10.1101/2022.04.05.486973 — immunology — Posted on 2022-04-07

2968 Comparative study between radiofrequency- and muscimol-induced inhibition of cultured networks of cortical neuron

Lemercier, C. E.; Garenne, A.; Poulletier de Gannes, F.; El Khoueiry, C.; Arnaud-Cormos, D.; Leveque, P.; Lagroye, I.; Percherancier, Y.; Lewis, N.

10.1101/2022.04.05.487108 — neuroscience — Posted on 2022-04-07

2969 Developmental switch in prediction and adaptation to pain in human neonates

Rupawala, M.; Bucsea, O.; Laudiano-Dray, M. P.; Whitehead, K.; Meek, J.; Fitzgerald, M.; Olhede, S.; Jones, L.; Fabrizi, L.

10.1101/2022.04.05.486988 — neuroscience — Posted on 2022-04-07

2970 Attentional rhythms are generated in binocular cells

Dong, B.; Zu, G.; Jia, J.; Chen, A.; Zhang, M.

10.1101/2022.04.05.487107 — neuroscience — Posted on 2022-04-07

2971 Single-neuron bursts encode pathological oscillations in Parkinson's disease and essential tremor

Scherer, M.; Steiner, L. A.; Kalia, S. K.; Hodaie, M.; Kuehn, A. A.; Lozano, A. M.; Hutchison, W. D.; Milosevic, L.

10.1101/2022.04.05.486956 — neuroscience — Posted on 2022-04-07

2972 Blood oxygenation-level dependent cerebrovascular reactivity imaging as strategy to monitor CSF-hemoglobin toxicity

Thomson, B. R.; Richter, H.; Akeret, K.; Buzzi, R. M.; Anagnostakou, V.; van Niftrik, B. H. B.; Schwendinger, N.; Kulcsar, Z.; Kronen, P. W.; Regli, L.; Fierstra, J.; Schaer, D. J.; Hugelshofer, M.

10.1101/2022.04.05.487168 — neuroscience — Posted on 2022-04-07

2973 Concentration dependent dual effect of the endozepine ODN on neuronal spiking activity

HAZIME, M.; GASSELIN, M.; ALASOADURA, M.; LANFRAY, D.; LECLERC, J.; LEFRANC, B.; BASILE, M.; DUPARC, C.; VAUDRY, D.; LEPRINCE, J.; CHUQUET, J.

10.1101/2022.04.05.487159 — neuroscience — Posted on 2022-04-07

2974 Effects of experiencing CS-US pairings on instructed fear reversal

Wisniewski, D.; Braem, S.; Gonzalez-Garcia, C.; De Houwer, J.; Brass, M.

10.1101/2022.04.05.487162 — neuroscience — Posted on 2022-04-07

2975 MicroRNA inhibition using antimiRs in acute human brain tissue sections

Morris, G.; Langa, E.; Fearon, C.; Conboy, K.; E-How, K. L.; Sanz-Rodriguez, A.; O'Brien, D. F.; Sweeney, K.; Lacey, A.; Delanty, N.; Beausang, A.; Brett, F. M.; Cryan, J.; Cunningham, M. O.; Henshall, D. C.

10.1101/2022.04.05.487136 — neuroscience — Posted on 2022-04-07

2976 The pitfalls of measuring representational similarityusing representational similarity analysis

Dujmovic, M.; Bowers, J.; Adolfi, F.; Malhotra, G.

10.1101/2022.04.05.487135 — neuroscience — Posted on 2022-04-07

2977 Nucleation complex behaviour is critical for cortical microtubule array homogeneity and patterning

Jacobs, B.; Schneider, R.; Molenaar, J.; Filion, L.; Deinum, E. E.

10.1101/2022.04.05.487129 — plant biology — Posted on 2022-04-07

2978 Hyperglycemia and Cancer. Human lung carcinoma by means of Raman spectroscopy and imaging

Abramczyk, H.; Kopec, M.; Beton, K.

10.1101/2022.04.05.487128 — cancer biology — Posted on 2022-04-07

2979 Direct evidence for pinning of single, ice-bound antifreeze proteins by subzero nanoscopy

Tas, R. P.; Hendrix, M. M.; Voets, I. K.

10.1101/2022.04.05.487137 — biophysics — Posted on 2022-04-07

2980 SimSearch: A Human-in-the-Loop Learning Framework for Fast Detection of Regions of Interest in Microscopy Images

Gupta, A.; Sabirsh, A.; Wahlby, C.; Sintorn, I.-M.

10.1101/2022.04.05.487117 — bioinformatics — Posted on 2022-04-07

2981 Extracting multiple surfaces from 3D microscopy images in complex biological tissues with the Zellige software tool.

Trebeau, C.; Boutet de Monvel, J.; Altay, G.; Tinevez, J.-Y.; Etournay, R.

10.1101/2022.04.05.485876 — bioinformatics — Posted on 2022-04-07

2982 QuasiFlow: a bioinformatic tool for genetic variability analysis from next generation sequencing data

Seoane, P.; Diaz-Martinez, L.; Viguera, E.; Claros, M. G.; Grande-Perez, A.

10.1101/2022.04.05.487169 — bioinformatics — Posted on 2022-04-07

2983 Can the Insect Path Integration Memory be a Bump Attractor?

Pisokas, I.; Hennig, M. H.

10.1101/2022.04.05.487126 — animal behavior and cognition — Posted on 2022-04-07

2984 Asynchrony rescues statistically-optimal group decisions from information cascades through emergent leaders

Reina, A.; Bose, T.; Srivastava, V.; Marshall, J. A. R.

10.1101/2022.04.05.487127 — animal behavior and cognition — Posted on 2022-04-07

2985 Genomic signatures of selection associated with benzimidazole drug treatments in Haemonchus contortus field populations

Wit, J.; Workentine, M. L.; Redman, E.; Laing, R.; Stevens, L.; Cotton, J. A.; Chaudhry, U. N.; Ali, Q.; Andersen, E. C.; Yeaman, S.; Wasmuth, J. D.; Gilleard, J. S.

10.1101/2022.04.05.487096 — genomics — Posted on 2022-04-07

2986 Genomic characteristics, virulence and antimicrobial resistance in avian pathogenic Escherichia coli MTR_BAU02 strain isolated from layer farms in Bangladesh

Ievy, S.; Hoque, M. N. N.; Islam, M. S.; Sobur, M. A.; Rahman, M. S.; Ballah, F. M.; Rahman, M. B.; Hassan, J.; Khan, M. F. R.; Rahman, M. T.

10.1101/2022.04.05.487091 — genomics — Posted on 2022-04-07

2987 Potential impact of TE-derived sRNA on gene regulation in the grassBrachypodium distachyon

Wyler, M.; Keller, B.; Roulin, A.

10.1101/2022.04.05.487121 — genomics — Posted on 2022-04-07

2988 Doctoring Direct-to-Consumer Genetic Tests with DNA Spike-Ins

Ney, P.; Bhattacharya, A.; Ward, D.; Ceze, L. H.; Kohno, T.; Nivala, J.

10.1101/2022.04.01.486752 — genetics — Posted on 2022-04-07

2989 A Genome-Wide Association Analysis of Happiness: Consistent Genetic Effects Across the Lifespan and Across Genetic Ancestries in Multiple Cohorts.

Ward, J.; Lyall, L.; Cullen, B.; Strawbridge, R. J.; Zhu, X.; Stanciu, I.; Aman, A.; Niedzwiedz, C. L.; Anderson, J.; Bailey, M. E. S.; Lyall, D. M.; Pell, J.

10.1101/2022.04.05.487098 — genetics — Posted on 2022-04-07

2990 The evolutionary demise of a social interaction: social partners differ in the rate at which interacting phenotypes are lost

Bladon, E. K.; Pascoal, S.; Bird, N.; Mashoodh, R.; Kilner, R. M.

10.1101/2022.04.05.486946 — evolutionary biology — Posted on 2022-04-07

2991 Lichen speciation is sparked by a substrate requirement shift and reproduction mode differentiation

Kantelinen, A.; Printzen, C.; Poczai, P.; Myllys, L.

10.1101/2022.04.05.487118 — evolutionary biology — Posted on 2022-04-07

2992 Invasion of malaria mosquitoes natural population by parasitic nematodes Dirofilaria along Ob River basin in Western Siberia

Burlak, V. N.; Fedorova, V. S.; Artemov, G. N.

10.1101/2022.04.04.487071 — ecology — Posted on 2022-04-07

2993 The Selenoprotein P 3' untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation

Shetty, S. P.; Kiledjian, N. T.; Copeland, P. R.

10.1101/2020.11.23.394817 — molecular biology — Posted on 2022-04-07

2994 Analysis of non-human primate models for evaluating prion disease therapeutic efficacy

Mortberg, M. A.; Minikel, E. V.; Vallabh, S. M.

10.1101/2022.03.22.485331 — neuroscience — Posted on 2022-04-07

2995 The strength of feedback processing is associated with resistance to visual backward masking during illusory contour processing in adult humans.

Foxe, J. J.; Knight, E. J.; Myers, E. J.; Cao, C. Z.; Molholm, S.; Freedman, E. G.

10.1101/2022.04.04.487043 — neuroscience — Posted on 2022-04-07

2996 The theta paradox: 4-8 Hz EEG oscillations reflect both local sleep and cognitive control

Snipes, S.; Krugliakova, E.; Meier, E.; Huber, R.

10.1101/2022.04.04.487061 — neuroscience — Posted on 2022-04-07

2997 Reactivating ordinal position information from auditory sequence memory in human brains

Fan, Y.; Luo, H.

10.1101/2022.04.04.487064 — neuroscience — Posted on 2022-04-07

2998 Population modeling with machine learning can enhance measures of mental health - Open-Data Replication

Easley, T. O.; Chen, R.; Hannon, K.; Dutt, R. K.; Bijsterbosch, J. D.

10.1101/2022.04.04.487069 — neuroscience — Posted on 2022-04-07

2999 Goal-directed recruitment of Pavlovian biases through selective visual attention

Algermissen, J.; den Ouden, H. E. M.

10.1101/2022.04.05.487113 — neuroscience — Posted on 2022-04-07

3000 Mind the gap: Nodes of Ranvier are remodeled by chronic psychosocial stress and neuronal activity

Koskinen, M.-K.; Laine, M. A.; Abdollahzadeh, A.; Gigliotta, A.; Mazzini, G.; Journee, S. H.; Alenius, V.; Trontti, K.; Tohka, J.; Hyytia, P.; Sierra, A.; Hovatta, I.

10.1101/2022.04.05.487090 — neuroscience — Posted on 2022-04-07

3001 HOTARU: Automatic sorting system for large scale calcium imaging data

Takekawa, T.; Nomoto, M.; Asai, H.; Ohkawa, N.; Okubo-Suzuki, R.; Ghandour, K.; Sato, M.; Ohkura, M.; Nakai, J.; Muramatsu, S.-i.; Hayashi, Y.; Inokuchi, K.; Fukai, T.

10.1101/2022.04.05.487077 — neuroscience — Posted on 2022-04-07

3002 Development of a Novel PROTAC using the Nucleic Acid Aptamer as a Targeting Ligand for Tumor Selective Degradation of Nucleolin

Zhang, L.; Li, L.; Wang, X.; Liu, H.; Zhang, Y.; Xie, T.; Zhang, H.; Li, X.; Peng, T.; Sun, X.; Dai, J.; Liu, J.; Wu, W.; Ye, M.; Tan, W.

10.1101/2021.08.05.455211 — biochemistry — Posted on 2022-04-07

3003 The Roles of APOBEC-mediated RNA Editing in SARS-CoV-2 Mutations, Replication, and Fitness

Kim, K.; Calabrese, P.; Wang, S.; Qin, C.; Rao, Y.; Feng, P.; Chen, X.

10.1101/2021.12.18.473309 — microbiology — Posted on 2022-04-07

3004 Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice

Bedard, M. L.; Lord, J. S.; Perez, P. J.; Bravo, I. M.; Teklezghi, A. T.; Tarantino, L. M.; Diering, G. H.; McElligott, Z. A.

10.1101/2022.04.06.487380 — neuroscience — Posted on 2022-04-07

3005 Prediction of infectivity of SARS-CoV2: Mathematical model with analysis of docking simulation for spike proteins and angiotensin-converting enzyme 2

Takaoka, Y.; Sugano, A.; Morinaga, Y.; Ohta, M.; Miura, K.; Kataguchi, H.; Kumaoka, M.; Kimura, S.; Maniwa, Y.

10.1101/2022.03.30.486373 — bioinformatics — Posted on 2022-04-07

3006 Optimal strategies for learning multi-ancestry polygenic scores vary across traits

Lehmann, B.; Mackintosh, M.; McVean, G.; Holmes, C. C.

10.1101/2021.01.15.426781 — genomics — Posted on 2022-04-07

3007 Genomic architecture controls spatial structuring in Amazonian birds

Thom, G.; Moreira, L. R.; Batista, R.; Gehara, M.; Aleixo, A.; Smith, B. T.

10.1101/2021.12.01.470789 — genomics — Posted on 2022-04-07

3008 Efficient Neutralization of SARS-CoV-2 Omicron and Other VOCs by a Broad Spectrum Antibody 8G3

Ma, H.; Tseng, C.-T. K.; Zong, H.; Liao, Y.; Ke, Y.; Tang, H.; Wang, L.; Wang, Z.; He, Y.; Chang, Y.; Wang, S.; Drelich, A.; Hsu, J.; Tat, V.; Yuan, Y.; Wu, M.; Liu, J.; Yue, Y.; Xu, W.; Zhang, X.; Wang, Z.; Yang, L.; Chen, H.; Bian, Y.; Zhang, B.; Yin, H.; Chen, Y.; Zhang, E.; Zhang, X.; Gilly, J.; Sun, T.; Han, L.; Xie, Y.; Jiang, H.; Zhu, J.

10.1101/2022.02.25.482049 — cell biology — Posted on 2022-04-07

3009 Cell Rearrangement Generates Pattern Emergence as a Function of Temporal Morphogen Exposure.

Fulton, T.; Spiess, K.; Thomson, L.; Wang, Y.; Clark, B.; Hwang, S.; Paige, B.; Verd, B.; Steventon, B.

10.1101/2021.02.05.429898 — developmental biology — Posted on 2022-04-07

3010 A conserved enzyme found in diverse human gut bacteria interferes with anticancer drug efficacy

Kyaw, T. S.; Spanogiannopoulos, P.; Guthrie, B. G. H.; Bradley, P. H.; Lee, J. V.; Melamed, J.; Malig, Y. N. A.; Lam, K. N.; Gempis, D.; Sandy, M.; Kidder, W.; van Blarigan, E. L.; Atreya, C.; Venook, A.; Gerona, R. R.; Goga, A. N.; Pollard, K. S.; Turnbaugh, P.

10.1101/820084 — microbiology — Posted on 2022-04-07

3011 JACKIE: Fast enumeration of genomic single- and multi-copy target sites and their off-targets for CRISPR and other engineered nuclease systems

Zhu, J. J.; Cheng, A. W.

10.1101/2020.02.27.968933 — bioinformatics — Posted on 2022-04-07

3012 Spontaneous parthenogenesis in the parasitoid wasp Cotesia typhae: low frequency anomaly or evolving process?

Capdevielle Dulac, C.; Benoist, R.; Paquet, S.; Calatayud, P.-A.; Obonyo, J.; Kaiser, L.; Mougel, F.

10.1101/2021.12.13.472356 — evolutionary biology — Posted on 2022-04-07

3013 Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition

Chann, A. S.; Charnley, M.; Newton, L.; Newbold, A.; Humbert, P. O. O.; Johnstone, R. W.; Russell, S.

10.1101/2021.10.03.462949 — developmental biology — Posted on 2022-04-07

3014 Quantitative Models of Lipid Transfer and Membrane Contact Formation

Zhang, Y.; Ge, J.; Bian, X.; Kumar, A.

10.1101/2022.01.17.476625 — biophysics — Posted on 2022-04-07

3015 The activity and functions of soil microbial communities in the Finnish sub-Arctic vary across vegetation types

Viitamaki, S.; Pessi, I. S.; Virkkala, A.-M.; Niittynen, P.; Kemppinen, J.; Eronen-Rasimus, E.; Luoto, M.; Hultman, J.

10.1101/2021.06.12.448001 — microbiology — Posted on 2022-04-07

3016 Inter-individual deep image reconstruction

Ho, J. K.; Horikawa, T.; Majima, K.; Kamitani, Y.

10.1101/2021.12.31.474501 — neuroscience — Posted on 2022-04-07

3017 Odorant receptor orthologues in conifer-feeding beetles display conserved responses to ecologically relevant odors

Roberts, R. E.; Biswas, T.; Yuvaraj, J. K.; Grosse-Wilde, E.; Powell, D.; Hansson, B. S.; Lofstedt, C.; Andersson, M. N.

10.1101/2022.02.22.481428 — neuroscience — Posted on 2022-04-07

3018 3D Reconstructions of Mouse Skeletal Muscle and Heart Muscle Reveal a Decrease in the MICOS Complex and Altered Mitochondrial Networks

Vue, Z.; Lopez, E. G.; Neikirk, K.; Vang, L.; Beasley, H.; Marshall, A.; Crabtree, A.; Hinton, A.

10.1101/2022.03.22.485341 — biophysics — Posted on 2022-04-07

3019 Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients

Herzog, L. E.; Wang, L.; Yu, E.; Choi, S.; Farsi, Z.; Song, B.; Pan, J. Q.; Sheng, M.

10.1101/2022.04.05.487037 — neuroscience — Posted on 2022-04-07

3020 Non-monotonic effects of GABAergic synaptic inputs on neuronal firing

Zadeh, A. A.; Turner, B. D.; Calakos, N.; Brunel, N.

10.1101/2021.12.07.471426 — neuroscience — Posted on 2022-04-07

3021 Older circuits get richer: neurogenesis timeline shapes hubness and neurogenetic profiles of the adult human brain

diez, I.; Moreno, F. G.; Sainz, N. C.; Stramaglia, S.; Reyes, A. N.; D'Amato, M.; Cortes, J. M.; bonifazi, p.

10.1101/2022.04.01.486541 — neuroscience — Posted on 2022-04-07

3022 Transcriptional targets of senataxin and E2 promoter binding factors are associated with neuro-degenerative pathways during increased autophagic flux

Casey, A.; Liu, W.; Hein, L.; Sargeant, T.; Pederson, S. M.; Mäkinen, V.-P.

10.1101/2022.04.06.486307 — genomics — Posted on 2022-04-07

3023 Unexpected inhibition of motor function by dopamine activation of D1/D2 co-expressing striatal neurons.

Bonnavion, P.; Varin, C.; Fakhfouri, G.; De Groote, A.; Cornil, A.; Isingrini, E.; Rainer, Q.; Xu, K.; Tzavara, E.; Vigneault, E.; Dumas, S.; de Kerchove d'Exaerde, A.; GIROS, B.

10.1101/2022.04.05.487163 — neuroscience — Posted on 2022-04-07

3024 Auditory Language Comprehension During Saccadic Eye Movements: An Investigation Using the N400 Event-Related Brain Potential

Dimigen, O.; Schild, U.; Hohlfeld, A.; Sommer, W.

10.1101/2022.04.05.487157 — neuroscience — Posted on 2022-04-07

3025 A visual representation of the hand in the resting somatomotor regions of the human brain

El Rassi, Y.; Handjaras, G.; Leo, A.; Papale, P.; Corbetta, M.; Ricciardi, E.; Betti, V.

10.1101/2022.04.05.486995 — neuroscience — Posted on 2022-04-07

3026 Signalling speed along a key white matter tract influences memory recall ability in humans

Clark, I. A.; Mohammadi, S.; Callaghan, M. F.; Maguire, E. A.

10.1101/2022.04.06.487313 — neuroscience — Posted on 2022-04-07

3027 Cardiac hemodynamics and ventricular stiffness of sea-run cherry salmon (Oncorhynchus masou masou) differ critically from those of landlocked masu salmon

Usui, Y.; Kimoto, M.; Hanashima, A.; Hashimoto, K.; Mohri, S.

10.1101/2022.04.06.487371 — physiology — Posted on 2022-04-06

3028 Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site

Rennie, M. L.; Arkinson, C.; Chaugule, V. K.; Walden, H.

10.1101/2022.04.06.487267 — biochemistry — Posted on 2022-04-06

3029 Novel Bruton's Tyrosine Kinase (BTK) substrates for time-resolved luminescence assays

Widstrom, N.; Perez, M.; Pratt, E. D.; Heier, J. L.; Blankenhorn, J. F.; Breidenbach, L.; Peterson, H.; Parker, L. L.

10.1101/2022.04.05.487161 — biochemistry — Posted on 2022-04-06

3030 The intergenerational transmission of educational attainment: A closer look at the (interrelated) roles of paternal involvement and genetic inheritance

Verweij, R. M.; Keizer, R.

10.1101/2022.04.06.487369 — genetics — Posted on 2022-04-06

3031 The genetic basis of structural colour variation in mimetic Heliconius butterflies

Brien, M. N.; Enciso Romero, J.; Lloyd, V. J.; Curran, E. V.; Parnell, A. J.; Morochz, C.; Salazar, P. A.; Rastas, P.; Zinn, T.; Nadeau, N. J.

10.1101/2021.04.21.440746 — evolutionary biology — Posted on 2022-04-06

3032 Evidence of attack deflection suggests adaptive evolution of wing tails in butterflies

Chotard, A.; Ledamoisel, J.; Decamps, T.; Herrel, A.; Chaine, A.; Llaurens, V.; Debat, V.

10.1101/2022.04.05.487106 — evolutionary biology — Posted on 2022-04-06

3033 Agricultural margins could enhance landscape connectivity for pollinating insects across the Central Valley of California, U.S.A.

Dilts, T. E.; Black, S.; Hoyle, S.; Jepsen, S.; May, E.; Forister, M.

10.1101/2022.04.06.487372 — ecology — Posted on 2022-04-06

3034 Bi-phasic regulation of AIMP2 and its splice variant in PARP-1- dependent neurodegeneration

Choi, J. W.; Lee, M. H.; Byun, M. R.; Lee, S. W.; Lee, E. J.; Jo, Y. O.; Kim, S. H.; Seol, W.; Baek, K.

10.1101/2022.04.06.487280 — molecular biology — Posted on 2022-04-06

3035 Transformation of the symbiotic alga Oophila amblystomatis : a new toolbox for animal-algae symbiosis studies.

Genot, B.; Burns, J. A.

10.1101/2022.04.06.487339 — molecular biology — Posted on 2022-04-06

3036 The cytolethal distending toxin modulates cell differentiation and elicits epithelial to mesenchymal transition

AZZi-MARTIN, L.; Touffait-Calvez, V.; Everaert, M.; Jia, R.; Sifre, E.; Seeneevassen, L.; Varon, C.; Dubus, P.; Menard, A.

10.1101/2022.04.06.487255 — microbiology — Posted on 2022-04-06

3037 KSHV Topologically Associating Domains in Latent and Reactivated Viral Chromatin

Campbell, M.; Chantarasrivong, C.; Yanagihashi, Y.; Inagaki, T.; Davis, R. R.; Nakano, K.; Kumar, A.; Tepper, C.; Izumiya, Y.

10.1101/2022.04.05.487244 — microbiology — Posted on 2022-04-06

3038 Microaerobic conditions and the complex regulation of natural competence in Staphylococcus aureus

Feng, S. Y.; Hauck, Y.; Morgene, M. F.; Mohammedi, R.; Mirouze, N.

10.1101/2022.04.06.487305 — microbiology — Posted on 2022-04-06

3039 Host range expansion of Shigella phage Sf6 evolves through the dual roles of its tailspike

Subramanian, S.; Dover, J. A.; Parent, K. N.; Doore, S. M.

10.1101/2022.04.06.487239 — microbiology — Posted on 2022-04-06

3040 An ALE meta-analytic review of musical expertise

Criscuolo, A.; Pando-Naude, V.; Bonetti, L.; Vuust, P.; Brattico, E.

10.1101/2021.03.12.434473 — neuroscience — Posted on 2022-04-06

3041 Spectral fiber-photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity

Zhang, W.-T.; Chao, T.-H. H.; Yang, Y.; Wang, T.-W.; Lee, S.-H.; Oyarzabal, E. A.; Zhou, J.; Nonneman, R.; Pegard, N. C.; Zhu, H.; Cui, G.; Shih, Y.-Y. I.

10.1101/2021.08.23.457372 — neuroscience — Posted on 2022-04-06

3042 The purified recombinant FAT domain of the Focal Adhesion Kinase does not bind directly to recombinant Talin or MBD2 in vitro

Naser, R.; Momin, A. A.; Ali, A. j.; Merzaban, J.; Arold, S. T.

10.1101/2022.04.06.487260 — biophysics — Posted on 2022-04-06

3043 Effective holistic characterization of small molecule effects using heterogeneous biological networks

Mangione, W.; Falls, Z.; Samudrala, R.

10.1101/2022.03.23.485550 — bioinformatics — Posted on 2022-04-06

3044 Double trouble: having two hosts reduces infection prevalence in vectored trypanosomatids

Al-Ghafli, H.; Barribeau, S. M.

10.1101/2021.04.29.440076 — evolutionary biology — Posted on 2022-04-06

3045 Comparing Imaging Biomarkers of Cerebral Edema after TBI in Young Adult Male and Female Rats

Minchew, H. M.; Ferren, S. L.; Christian, S. K.; Hu, J.; Keselman, P.; Brooks, W. M.; Andrews, B. T.; Harris, J. L.

10.1101/2021.06.25.449932 — neuroscience — Posted on 2022-04-06

3046 A New Paradigm for Investigating Real-World Social Behavior and its Neural Underpinnings

Alreja, A.; Ward, M. J.; Ma, Q.; Russ, B.; Bickel, S.; Van Wouwe, N.; Gonzalez-Martinez, J. A.; Neimat, J.; Abel, T. J.; Bagic, A.; Parker, L. S.; Richardson, M.; Schroeder, C. E.; Morency, L.-P.; Ghuman, A. S.

10.1101/2021.12.26.474173 — neuroscience — Posted on 2022-04-06

3047 Milking it for all it's worth: The effects of environmental enrichment on maternal nurturance, lactation quality, and offspring social behavior

DeRosa, H.; Caradonna, S. G.; Tran, H.; Marrocco, J.; Kentner, A. C.

10.1101/2021.12.13.472509 — neuroscience — Posted on 2022-04-06

3048 Building model prototypes from time-course data

Veliz-Cuba, A.; Voss, R.; Murrugarra, D.

10.1101/2022.01.27.478080 — systems biology — Posted on 2022-04-06

3049 Organizing laboratory information to analyze the reproducibility of experimental workflows

Peccoud, J.; Johnson, D.; Peccoud, S.; Setchell, J.; Zhou, W.

10.1101/2022.04.05.487214 — synthetic biology — Posted on 2022-04-06

3050 Impact of temperature and time on DNA-free Cas9-ribonucleoprotein mediated gene editing in wheat protoplasts and immature embryos

Poddar, S.; Tanaka, J.; Running, K. L. D.; Kariyawasam, G. K.; Faris, J.; Friesen, T.; Cho, M.-J.; Cate, J. H.; Staskawicz, B.

10.1101/2022.04.05.487229 — plant biology — Posted on 2022-04-06

3051 Linked machine learning classifiers improve species classification of fungi when using error-prone long-reads on extended metabarcodes

Eenjes, T.; Hu, Y.; Irinyi, L.; Hoang, M. T.; Smith, L.; Linde, C.; Milgate, A.; Meyer, W.; Stone, E.; Rathjen, J. P.; Mashford, B.; Schwessinger, B.

10.1101/2021.05.01.442223 — bioinformatics — Posted on 2022-04-06

3052 Isolating salient variations of interest in single-cell transcriptomic data with contrastiveVI

Weinberger, E.; Lin, C.; Lee, S.-I.

10.1101/2021.12.21.473757 — bioinformatics — Posted on 2022-04-06

3053 Laboratory-acquired mutations fall outside the wild-type alleleome of Escherichia coli

Catoiu, E. A.; Phaneuf, P. V.; Monk, J.; Palsson, B.

10.1101/2022.04.04.487056 — bioengineering — Posted on 2022-04-06

3054 Selecting an effective amplitude threshold for neural spike detection

zhang, z.; Constandinou, T.

10.1101/2022.01.25.477685 — bioengineering — Posted on 2022-04-06

3055 Cell-free mutant analysis combined with structure prediction of a lasso peptide biosynthetic protein B2

Alfi, A.; Popov, A.; Kumar, A.; Zhang, K. Y. J.; Dubiley, S.; Severinov, K.; Tagami, S.

10.1101/2022.04.06.487251 — biochemistry — Posted on 2022-04-06

3056 Understanding the Spin Crossover Dynamical Effects of the Dioxygen Binding and Activation on HOD enzyme

Du, L.

10.1101/2022.04.05.487120 — biochemistry — Posted on 2022-04-06

3057 Multiplexed promoter and gene editing in wheat using the virus-based guide RNA delivery system

Wang, W.; Yu, Z.; He, F.; Bai, G.; Trick, H. N.; Akhunova, A.; Akhunov, E.

10.1101/2022.04.06.484365 — genetics — Posted on 2022-04-06

3058 Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord

Wang, Y.-w.; Wreden, C. C.; Levy, M.; Marshall, Z. D. D.; MacLean, J. N.; Heckscher, E. S.

10.1101/2022.04.05.487221 — developmental biology — Posted on 2022-04-06

3059 Extracellular Vesicles from PRPF31+/- iPSC-Derived RPE Have a Distinct RNA Profile Compared to Those From Healthy RPE

Getachew, H.; Mehrotra, S.; Fernandez-Godino, R.; Pierce, E. A.

10.1101/2022.04.05.487197 — molecular biology — Posted on 2022-04-06

3060 Listeria monocytogenes Co-opts Caveolin-Mediated E-cadherin Trafficking and Macropinocytosis for Epithelial Cell-to-Cell Spread

Radhakrishnan, P.; Sathe, M.; Theriot, J. A.

10.1101/2022.04.06.487361 — microbiology — Posted on 2022-04-06

3061 A multidrug-resistant Salmonella enterica serotype Typhimurium DT104 lineage circulating among humans and cattle in the United States lost the ability to produce pertussis-like toxin ArtAB in close temporal proximity to the global DT104 epidemic

Carroll, L. M.; Piacenza, N.; Cheng, R. A.; Wiedmann, M.; Guldimann, C.

10.1101/2022.04.06.487395 — microbiology — Posted on 2022-04-06

3062 Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen.

Fullen, A. R.; Gutierrez-Ferman, J. L.; Yount, K. S.; Love, C. F.; Choi, H. G.; Vargas, M. A.; Raju, D.; Corps, K. N.; Howell, P. L.; Dubey, P.; Deora, R.

10.1101/2022.04.06.487353 — microbiology — Posted on 2022-04-06

3063 Genome-wide fitness analysis identifies genes required for in vitro growth and macrophage infection by African and Global Epidemic pathovariants of Salmonella Enteritidis

Fong, W. Y.; Canals, R.; Predeus, A. V.; Perez-Sepulveda, B.; Wenner, N.; Lacharme-Lora, L.; Feasey, N.; Wigley, P.; Hinton, J. C. D.

10.1101/2022.04.06.487138 — microbiology — Posted on 2022-04-06

3064 MazeMaster: an open-source Python-based software package for controlling virtual reality experiments

Bexter, A.; Kampa, B. M.

10.1101/2020.01.27.921148 — neuroscience — Posted on 2022-04-06

3065 Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model

Kuhn, T.; Landge, A. N.; Moersdorf, D.; Cossmann, J.; Gerstenecker, J.; Mueller, P.; Gebhardt, J. C. M.

10.1101/2022.04.05.487143 — biophysics — Posted on 2022-04-06

3066 Structure Of Eukaryotic Type III Glutamine Synthetase Lacking Ring-Ring Quaternary Contacts

Novikova, I. V.; Powell, S.; Smallwood, C.; Purvine, S. O.; Zhou, M.; Evans, J. E.

10.1101/2022.04.05.486999 — biochemistry — Posted on 2022-04-06

3067 Cryo-EM structure of the diapause chaperone artemin

Parvate, A.; Powell, S.; Brookreson, J.; Moser, T.; Novikova, I. V.; Zhou, M.; Evans, J. E.

10.1101/2022.04.06.487001 — biochemistry — Posted on 2022-04-06

3068 Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus

Ranga-Prasad, H.; Jenkins, M. L.; Parson, M. A.; Rathinaswamy, M. K.; Burke, J. E.

10.1101/2022.04.05.487205 — biochemistry — Posted on 2022-04-06

3069 The {varphi}PA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice

Nieweglowska, E. S.; Brilot, A. F.; Mendez, M.; Baek, M.; Li, J.; Kokontis, C.; Cheng, Y.; Baker, D.; Bondy-Denomy, J.; Agard, D. A.

10.1101/2022.04.06.487387 — biochemistry — Posted on 2022-04-06

3070 Overlapping and distinct cis-acting requirements for oskar mRNA localization pathways

Eichler, C. E.; Grunberg, M. E.; Gavis, E. R.

10.1101/2022.04.04.487058 — developmental biology — Posted on 2022-04-06

3071 Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signalling

Marechal, E.; Poliard, A.; Moreno, M.; Legrix, M.; Macagno, N.; Mondielli, G.; Fauquier, T.; Barlier, A.; Etchevers, H. C.

10.1101/2022.04.05.487130 — developmental biology — Posted on 2022-04-06

3072 New system for serial crystallography data collection at SBC APS

Joachimiak, A.; Sherrell, D. A.; Lavens, A.; Wilamowski, M.; Kim, Y.; Chard, R.; Lazarski, K.; Rosenbaum, G.; Rescovi, R.; Johnson, J. L.; Akins, C.; Chang, C.; Michalska, K.; Babnigg, G.; Foster, I.

10.1101/2022.04.06.487333 — molecular biology — Posted on 2022-04-06

3073 Structural studies of hepatitis C virus non-structural protein-5b of genotype 4a

Gaber, H.; Niessing, D.; Protzer, U.; Janowski, R.

10.1101/2022.04.06.486972 — molecular biology — Posted on 2022-04-06

3074 Disentangling leaf-microbiome interactions in Arabidopsis thaliana by network mapping

Li, K.; Cheng, K.; Wang, H.; Zhang, Q.; Yang, Y.; Jin, Y.; HE, X.; Wu, R.

10.1101/2022.04.05.487248 — microbiology — Posted on 2022-04-06

3075 Barcoding genetically distinct Plasmodium falciparum strains for comparative assessment of fitness and antimalarial drug resistance

Carrasquilla, M.; Drammeh, N. F.; Rawat, M.; Sanderson, T.; Zenonos, Z.; Rayner, J. C.; Lee, M.

10.1101/2022.04.05.487250 — microbiology — Posted on 2022-04-06

3076 Unexpected Complexity of the Ammonia Monooxygenase in Archaea

Hodgskiss, L. H.; Melcher, M.; Kerou, M.; Chen, W.; Ponce-Toledo, R. I.; Savvides, S. N.; Wienkoop, S.; Hartl, M.; Schleper, C.

10.1101/2022.04.06.487334 — microbiology — Posted on 2022-04-06

3077 Using Culture-Enriched Phenotypic Metagenomics for Targeted High-Throughput Monitoring of Clinically-Important Fraction of Beta-Lactam Resistome

Zhang, Z.; Zhang, G.; Ju, F.

10.1101/2022.04.06.487307 — microbiology — Posted on 2022-04-06

3078 Culexarchaeia, a novel archaeal class of anaerobic generalists inhabiting geothermal environments

Kohtz, A. J.; Jay, Z. J.; Lynes, M.; Krukenberg, V.; Hatzenpichler, R.

10.1101/2022.04.06.487207 — microbiology — Posted on 2022-04-06

3079 Dental pulp metagenomics reveals ancient human Herpesviridae.

Oumarou Hama, H.; Zandotti, C.; Loukil, A.; Gazin, C.; Jonvel, R.; Georges-Zimmermann, P.; Decker, M.; Fournier, P.-E.; Barbieri, R.; Aboudharam, G.; Drancourt, M.

10.1101/2022.04.06.487315 — microbiology — Posted on 2022-04-06

3080 A positive feedback loop controls Toxoplasma chronic differentiation

Licon, M. H.; Giuliano, C. J.; Chakladar, S.; Shallberg, L.; Waldman, B. S.; Hunter, C. A.; Lourido, S.

10.1101/2022.04.06.487076 — microbiology — Posted on 2022-04-06

3081 Extended genomic analyses of the broad-host-range phages vB_KmiM-2Di and vB_KmiM-4Dii reveal slopekviruses have highly conserved genomes

Smith-Zaitlik, T.; Shibu, P.; McCartney, A. L.; Foster, G.; Hoyles, L.; Negus, D.

10.1101/2022.04.06.486684 — microbiology — Posted on 2022-04-06

3082 Evidence for complex interplay between quorum sensing and antibiotic resistance in Pseudomonas aeruginosa

Sikdar, R.; Elias, M.

10.1101/2022.04.05.487235 — microbiology — Posted on 2022-04-06

3083 Screening of the optimal CpG-oligodeoxynucleotide for anti-inflammatory responses in avian macrophage cell line HD11

Ichikawa, K.; Matsuzaki, M.; Ezaki, R.; Horiuchi, H.; Yamamoto, Y.

10.1101/2022.04.05.487094 — immunology — Posted on 2022-04-06

3084 The potyviral protein 6K2 from Turnip mosaic virus increases plant resilience to drought

Prakash, V.; Nihranz, C. T.; Casteel, C. L.

10.1101/2022.04.04.487062 — plant biology — Posted on 2022-04-06

3085 PEP7 is a ligand for receptor kinase SIRK1 to regulate aquaporins and root growth

Wang, J.; Xi, L.; Wu, X. N.; Koenig, S.; Rohr, L.; Neumann, T.; Harter, K.; Schulze, W. X.

10.1101/2022.04.05.486672 — plant biology — Posted on 2022-04-06

3086 Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection

Ang, C. W.; Lee, B. M.; Jackson, C. J.; Wang, Y.; Franzblau, S. G.; Francisco, A. F.; Kelly, J. M.; Bernhardt, P. V.; Tan, L.; West, N. P.; Sykes, M. L.; Hinton, A. O.; Bolisetti, R.; Avery, V. M.; Cooper, M. A.; Blaskovich, M.

10.1101/2022.04.05.487095 — pharmacology and toxicology — Posted on 2022-04-06

3087 Overexpression of TopBP1 leads to transformation with a TP53 mutation of non-tumorigenic breast epithelial cells

Umesh, R. M.; Lahiri, M.

10.1101/2022.04.05.487132 — cancer biology — Posted on 2022-04-06

3088 Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B

Orädd, F.; Steffen, J. H.; Gourdon, P.; Andersson, M.

10.1101/2022.04.05.487099 — biophysics — Posted on 2022-04-06

3089 Architecture of the chikungunya virus replication organelle

Laurent, T.; Kumar, P.; Liese, S.; Zare, F.; Pernebrink, M.; Carlson, A.; Carlson, L.-A.

10.1101/2022.04.05.487153 — biophysics — Posted on 2022-04-06

3090 Deep Local Analysis evaluates protein docking conformations with locally oriented cubes

Mohseni Behbahani, Y.; Crouzet, S.; Laine, E.; Carbone, A.

10.1101/2022.04.05.487134 — bioinformatics — Posted on 2022-04-06

3091 Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation, and ssDNA binding kinetics

Orris, B.; Huynh, K. W.; Ammirati, M.; Han, S.; Bolanos, B.; Carmody, J.; Petroski, M. D.; Bosbach, B.; Shields, D. J.; Stivers, J. T.

10.1101/2022.04.05.486416 — biochemistry — Posted on 2022-04-06

3092 Impact of energy limitations on function and resilience in long-wavelength Photosystem II

Viola, S.; Roseby, W.; Santabarbara, S.; Nuernberg, D. J.; Assuncao, R.; Dau, H.; Selles, J.; Boussac, A.; Fantuzzi, A.; Rutherford, A. W.

10.1101/2022.04.05.486971 — biochemistry — Posted on 2022-04-06

3093 An Ultralong Bovine CDRH3 that Targets a Conserved, Cryptic Epitope on SARS-CoV and SARS-CoV-2

Burke, M. J.; Scott, J. N.; Minshull, T.; Stockley, P. G.; Calabrese, A. N.; Boyes, J.

10.1101/2022.04.06.487306 — molecular biology — Posted on 2022-04-06

3094 Advanced transcriptomic analysis reveals the role of efflux pumps and media composition in antibiotic responses of Pseudomonas aeruginosa

Rajput, A.; Tsunemoto, H.; Sastry, A. V.; Szubin, R.; Rychel, K.; Chauhan, S. M.; Pogliano, J.; Palsson, B.

10.1101/2022.04.04.487074 — systems biology — Posted on 2022-04-06

3095 State Dependent Anionic Pore Currents Conducted by Single Countercharge Mutants in a Voltage-Sensing Phosphatase

Shen, R.; Perozo, E.; Roux, B.

10.1101/2022.04.04.487073 — biophysics — Posted on 2022-04-06

3096 Exploring the effect of mechanical anisotropy of protein structures in the unfoldase mechanism of AAA+ molecular machines

Varikoti, R. A.; Fonseka, H. Y. Y.; Kelly, M. S.; Javidi, A.; Damre, M.; Mullen, S.; Nugent, J. L.; Gonzales, C. M.; Stan, G.; Dima, R. I.

10.1101/2022.04.06.487390 — biophysics — Posted on 2022-04-06

3097 Cryo-EM reveals an entangled kinetic trap in the folding pathway of a catalytic RNA

Bonilla, S. L.; Vicens, Q.; Kieft, J. S.

10.1101/2022.04.05.487152 — biochemistry — Posted on 2022-04-06

3098 Conserved degronome features governing quality control-associated proteolysis

Mashahreh, B.; Armony, S.; Johansson, K. E.; Chappleboim, A.; Friedman, N.; Gardner, R.; Hartmann-Petersen, R.; Lindorff-Larsen, K.; Ravid, T.

10.1101/2022.04.06.487275 — cell biology — Posted on 2022-04-06

3099 Salicin modifies osteoarthritis progression by binding on IRE1α and inhibiting IRE1α mediated endoplasmic reticulum stress

Zhu, Z.; Gao, S.; Chen, C.; Xu, W.; Xiao, P.; Chen, Z.; Du, C.; Chen, B.; Gao, Y.; Wang, C.; Liao, J.; Huang, W.

10.1101/2022.04.06.487311 — cell biology — Posted on 2022-04-06

3100 Redox sensing by SENP1 augments insulin secretion early after high-fat feeding in mice

Lin, H.; Suzuki, K.; Smith, N.; Li, X.; Nalbach, L.; Fuentes, S.; Spigelman, A. F.; Dai, X.-Q.; Bautista, A.; Ferdaoussi, M.; Aggarwal, S.; Pepper, A. R.; Roma, L. P.; Ampofo, E.; Li, W.-h.; MacDonald, P. E.

10.1101/2022.04.05.487203 — cell biology — Posted on 2022-04-06

3101 Introducing CELLBLOKS: a novel organ-on-a-chip platform allowing a plug-and-play approach towards building organotypic models

Llabjani, V.; Siddique, M. R.; Macos, A.; Abozoid, A.; Hoti, V.; Martin, F. L.; Patel, I. I.; Raza, A.

10.1101/2022.04.05.487165 — cell biology — Posted on 2022-04-06

3102 Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase

Pimenta-Marques, A. R.; Perestrelo, T.; Reis-Rodrigues, P.; Duarte, P.; Lince-Faria, M.; Bettencourt-Dias, M.

10.1101/2022.04.06.487296 — cell biology — Posted on 2022-04-06

3103 CARP2 regulates the Golgi dynamics upon EGF stimulation

Srinivasula, S. M.; SHARMA, R.

10.1101/2022.04.05.487156 — cell biology — Posted on 2022-04-06

3104 Delta-Omicron recombinant SARS-CoV-2 in a transplant patient treated with Sotrovimab

Duerr, R.; Dimartino, D.; Marier, C.; Zappile, P.; Wang, G.; Plitnick, J.; Griesemer, S.; Lasek-Nesselquist, E.; Dittman, M.; Ortigoza, M. B.; Prasad, P. J.; St. George, K.; Heguy, A.

10.1101/2022.04.06.487325 — microbiology — Posted on 2022-04-06

3105 SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein.

Parn, S.; Savsani, K.; Dakshanamurthy, S.

10.1101/2022.04.05.487186 — immunology — Posted on 2022-04-06

3106 Delineating antibody escape from Omicron variants

Gruell, H.; Vanshylla, K.; Korenkov, M.; Tober-Lau, P.; Zehner, M.; Muenn, F.; Janicki, H.; Augustin, M.; Schommers, P.; Sander, L. E.; Kurth, F.; Kreer, C.; Klein, F.

10.1101/2022.04.06.487257 — immunology — Posted on 2022-04-06

3107 ViReMaShiny: An Interactive Application for Analysis of Viral Recombination Data

Yeung, J.; Routh, A. L.

10.1101/2022.04.06.487215 — bioinformatics — Posted on 2022-04-06

3108 Vascular inflammation exposes perivascular cells to SARS-CoV-2 infection

Franca, C. M.; Mansoorifar, A.; Athirasala, A.; Subbiah, R.; Tahayeri, A.; Bertassoni, L. E.

10.1101/2022.04.05.487240 — bioengineering — Posted on 2022-04-06

3109 A weakly structured stem for human origins in Africa

Ragsdale, A. P.; Weaver, T. D.; Atkinson, E. G.; Hoal, E.; Moller, M.; Henn, B. M.; Gravel, S.

10.1101/2022.03.23.485528 — genomics — Posted on 2022-04-06

3110 Loss of LGR5 through plasticity or gene ablation is associated with therapy resistance and enhanced MET-STAT3 signaling in colorectal cancer cells

Posey, T. A.; Jacob, J.; Parkhurst, A. N.; Subramanian, S.; Francisco, L. E.; Liang, Z.; Carmon, K. S.

10.1101/2022.03.01.482539 — cancer biology — Posted on 2022-04-06

3111 Combined epigenetic and metabolic inhibition blocks platinum-induced ovarian cancer stem cell enrichment

Sood, R.; Sriramkumar, S.; Muralikrishnan, V.; Xiao, S.; Wang, W.; Hassel, C.; Nephew, K. P.; O'Hagan, H. M.

10.1101/2021.03.18.435878 — cancer biology — Posted on 2022-04-06

3112 Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI)

Liu, A.; Han, N.; Munoz-Muriedas, J.; Bender, A.

10.1101/2021.09.23.461089 — bioinformatics — Posted on 2022-04-06

3113 An early decline in ETPs reflects reduced pre-thymic progenitors and altered signals from the thymus microenvironment

Srinivasan, J.; Vasudev, A.; Selden, H. J.; Perez, E.; LaFleur, B. J.; Sinari, S. A.; Krueger, A.; Richie, E. R.; Ehrlich, L. I. R.

10.1101/2022.01.18.476832 — immunology — Posted on 2022-04-06

3114 Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2

Tsyklauri, O.; Chadimova, T.; Niederlova, V.; Kovarova, J.; Michalik, J.; Malatova, I.; Janusova, S.; Rossez, H.; Drobek, A.; Vecerova, H.; Galati, V.; Kovar, M.; Stepanek, O.

10.1101/2021.11.10.467495 — immunology — Posted on 2022-04-06

3115 Local biodiversity change reflects interactions among changing abundance, evenness and richness

Blowes, S.; Daskalova, G. N.; Dornelas, M.; Engel, T.; Gotelli, N. J.; Magurran, A.; Martins, I. S.; McGill, B.; McGlinn, D.; Sagouis, A.; Shimadzu, H.; Supp, S. R.; Chase, J.

10.1101/2021.08.29.458087 — ecology — Posted on 2022-04-06

3116 Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

Shi, G.; Chiramel, A. I.; Majdoul, S.; Lai, K. K.; Dempsey, T.; Kenney, A.; Zani, A.; Eddy, A.; Zhang, L.; Das, S.; Beare, P. A.; Andresson, T.; Kar, S.; Yount, J. S.; Best, S. M.; Compton, A. A.

10.1101/2021.04.15.440067 — microbiology — Posted on 2022-04-06

3117 Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies Against Delta and Omicron in Mice

Jansen van Vuren, P.; McAuley, A. J.; Kuiper, M. J.; Singanallur, N. B.; Bruce, M. P.; Riddell, S.; Goldie, S.; Mangalaganesh, S.; Chahal, S.; Drew, T. W.; Blasdell, K. R.; Tachedjian, M.; Caly, L.; Druce, J. D.; Ahmed, S.; Khan, M. S.; Malladi, S. K.; Singh, R.; Pandey, S.; Varadarajan, R.; Vasan, S. S.

10.1101/2022.03.03.481940 — immunology — Posted on 2022-04-06

3118 Modeling naturalistic face processing in humans with deep convolutional neural networks

Jiahui, G.; Feilong, M.; Visconti di Oleggio Castello, M.; Nastase, S. A.; Haxby, J. V.; Gobbini, M. I.

10.1101/2021.11.17.469009 — neuroscience — Posted on 2022-04-06

3119 Trends in Arabidopsis Research post genome sequencing- A Scientometric study

Kumar, S.; Kushwaha, A. K.; R, T.; M, B.; P, K.

10.1101/2022.02.22.481563 — plant biology — Posted on 2022-04-06

3120 An epigenetic memory of inflammation controls context-dependent lineage plasticity in the pancreas

Falvo, D. J.; Grimont, A.; Zumbo, P.; Yang, J. L.; Osterhoudt, A.; Pan, G.; Rendeiro, A. F.; Wilkinson, J. E.; Dündar, F.; Elemento, O.; Yantiss, R. K.; Betel, D.; Koche, R.; Chandwani, R.

10.1101/2021.11.01.466807 — cancer biology — Posted on 2022-04-06

3121 Vimentin intermediate filament assembly is a reversible process

Tran, Q. D.; Sorichetti, V.; Pehau-Arnaudet, G.; Lenz, M.; Leduc, C.

10.1101/2022.03.19.484978 — biophysics — Posted on 2022-04-06

3122 DRP1 regulates endoplasmic reticulum sheets to control mitochondrial DNA replication and segregation

Ilamathi, H. S.; Benhammouda, S.; Desrochers-Goyette, J.; Lines, M. A.; Germain, M.

10.1101/2021.12.09.472002 — cell biology — Posted on 2022-04-06

3123 A Neuromuscular Model of Human Locomotion Combines Spinal Reflex Circuits with Voluntary Movements

Ramadan, R.; Geyer, H.; Jeka, J. J.; Schoener, G.; Reimann, H.

10.1101/2021.09.26.461864 — neuroscience — Posted on 2022-04-06

3124 Visual Clustering of Transcriptomic Data from Primary and Metastatic Tumors - Dependencies and Novel Pitfalls

Marquardt, A.; Kollmannsberger, P.; Krebs, M.; Argentiero, A.; Knott, M.; Solimando, A. G.; Kerscher, A.

10.1101/2021.12.03.471112 — cancer biology — Posted on 2022-04-06

3125 Large protein complex interfaces have evolved to promote cotranslational assembly

Badonyi, M.; Marsh, J. A.

10.1101/2021.05.26.445863 — molecular biology — Posted on 2022-04-06

3126 Z-RNA and the flipside of the SARS Nsp13 helicase

Herbert, A.; Poptsova, M.

10.1101/2022.03.03.482810 — microbiology — Posted on 2022-04-06

3127 Novel AlphasynucleinPAN in human Mesenchymal Stem Cells-derived neurons masks SNCA140 and creates dissociation of deleterious SNCA98 in astrocytoma stem cells

owoola, A. G.; Okolicsanyi, R. K.; Griffiths, L. R.; Haupt, L. M.

10.1101/2022.02.08.479501 — neuroscience — Posted on 2022-04-06

3128 Ribosomes in RNA granules are stalled on mRNA sequences that are consensus sites for FMRP association.

Anadolu, M. N.; Sun, J.; Kailasam, s.; Simbriger, K.; Markova, T.; Jafarnejad, S. M.; Lefebvre, F.; Ortega, J.; Gkogkas, C. G.; Sossin, W. S.

10.1101/2021.02.22.432349 — neuroscience — Posted on 2022-04-06

3129 LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19

Shimizu, H.; Kodama, M.; Matsumoto, M.; Orba, Y.; Sasaki, M.; Sato, A.; Sawa, H.; Nakayama, K. I.

10.1101/2021.09.25.461785 — systems biology — Posted on 2022-04-06

3130 What can cold-induced transcriptomes of Arctic Brassicaceae tell us about the evolution of cold tolerance?

Birkeland, S.; Slotte, T.; Brysting, A. K.; Gustafsson, A. L. S.; Hvidsten, T. R.; Brochmann, C.; Nowak, M. D.

10.1101/2021.12.04.471218 — evolutionary biology — Posted on 2022-04-06

3131 Crowding changes appearance systematically in peripheral, amblyopic, and developing vision

Kalpadakis-Smith, A. V.; Tailor, V. K.; Dahlmann-Noor, A. H.; Greenwood, J. A.

10.1101/2021.11.30.470647 — neuroscience — Posted on 2022-04-06

3132 Illuminating the plant transposon insertion landscape in real time using Cas9-targeted Nanopore sequencing and a novel pipeline

Kirov, I.; Merkulov, P.; Gvaramiya, S.; Komakhin, R.; Omarov, M.; Dudnikov, M.; Kocheshkova, A.; Konstantinov, Z.; Soloviev, A.; Karlov, G.; Divashuk, M.

10.1101/2021.06.11.448052 — genomics — Posted on 2022-04-06

3133 Differential auditory and visual phase-locking are observed during audio-visual benefit and silent lip-reading for speech perception

Aller, M.; Okland, H. S.; MacGregor, L. J.; Blank, H.; Davis, M. H.

10.1101/2021.12.18.472955 — neuroscience — Posted on 2022-04-06

3134 Nonlinear super-resolution signal processing for subcellular analysis of calcium dynamics

Calcini, N.; da Silva Lantyer, A.; Zeldenrust, F.; Celikel, T.

10.1101/2022.01.29.478290 — neuroscience — Posted on 2022-04-06

3135 Toward an optimal contraception dosing strategy

Gavina, B. L. A.; de los Reyes, A. A.; Olufsen, M. S.; Lenhart, S.; Ottesen, J. T.

10.1101/2022.04.04.486926 — systems biology — Posted on 2022-04-06

3136 Non-cancer stem cell-derived Fibromodulin activates Integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

Somasundaram, K.; Sengupta, S.; Mondal, M.; Prasasvi, K. R.; Mukherjee, A.; Magod, P.; Urbach, S.; Friedmann-Morvinski, D.; Marin, P.

10.1101/2022.04.03.486893 — cancer biology — Posted on 2022-04-06

3137 Protist diversity and metabolic strategy in freshwater lakes are shaped by trophic state and watershed land use at a continental scale

Garner, R.; Kraemer, S. A.; Onana, V. E.; Huot, Y.; Gregory-Eaves, I.; Walsh, D. A.

10.1101/2022.04.04.487084 — ecology — Posted on 2022-04-06

3138 Identification of Antimalarial Compounds that Inhibit Apicomplexan AP2 Proteins

10.1101/2022.04.05.487101 — molecular biology — Posted on 2022-04-06

3139 Three Mutations Convert the Selectivity of a Protein Sensor From Nicotinic Agonists to S-Methadone For Use in Cells, Organelles, and Biofluids

Muthusamy, A. K.; Kim, C. H.; Virgil, S. C.; Knox, H. J.; Marvin, J. S.; Nichols, A. L.; Cohen, B. N.; Dougherty, D. A.; Looger, L. L.; Lester, H. A.

10.1101/2022.02.24.481226 — bioengineering — Posted on 2022-04-06

3140 Predicting long pendant edges in model phylogenies, with applications to biodiversity and tree inference

Bocharov, S.; Harris, S.; Kominek, E.; Mooers, A. O.; Steel, M.

10.1101/2021.09.11.459915 — evolutionary biology — Posted on 2022-04-06

3141 Older circuits get richer: neurogenesis timeline shapes hubness and neurogenetic profiles of the adult human brain

diez, I.; Moreno, F. G.; Sainz, N. C.; Stramaglia, S.; Reyes, A. N.; D'Amato, M.; Cortes, J. M.; bonifazi, p.

10.1101/2022.04.01.486541 — neuroscience — Posted on 2022-04-06

3142 Naturalistic viewing conditions can increase task engagement and aesthetic preference but have only minimal impact on EEG quality

Welke, D.; Vessel, E. A.

10.1101/2021.09.18.460905 — neuroscience — Posted on 2022-04-06

3143 Ecologically pre-trained RNNs explain suboptimal animal decisions

Molano-Mazon, M.; Shao, Y.; Duque, D.; Yang, G. R.; Ostojic, S.; de la Rocha, J.

10.1101/2021.05.15.444287 — neuroscience — Posted on 2022-04-06

3144 A hymenopteran odorant alerts flies to bury eggs

Davis, S. M.; Chism, G. T.; Maurer, M. M.; Trejo, J. E.; Garcia, R. J.; Schlenke, T. A.

10.1101/2021.09.30.462443 — animal behavior and cognition — Posted on 2022-04-05

3145 How to select the best model from AlphaFold2 structures?

Takei, Y.; Ishida, T.

10.1101/2022.04.05.487218 — bioinformatics — Posted on 2022-04-05

3146 Nonlinear Parameter and State Estimation Approach in End-stage Kidney Disease Patients

Abohtyra, R.; Vincent, T. L.

10.1101/2022.04.02.486844 — bioengineering — Posted on 2022-04-05

3147 Engineering Antioxidant and Oxygen-Releasing Lignin Composites to Accelerate Wound Healing

Balaji, S.; Short, W. D.; Padon, B. W.; Prajapati, T. J.; Farouk, F.; Kaul, A.; Belgodere, J. A.; Jimenez, S. E.; Deoli, N. T.; Guidry, A. C.; Green, J. C.; Son, D.; Keswani, S.; Jung, O. S.; Astete, C. E.; Kim, M.; Jung, J. P.

10.1101/2022.03.18.484913 — bioengineering — Posted on 2022-04-05

3148 Convergent genomic signatures of adaptation to an extreme environment in cyprinoid fishes

Tong, C.; Li, M.

10.1101/2022.03.30.486405 — evolutionary biology — Posted on 2022-04-05

3149 Nucleoporins facilitate ORC loading onto chromatin

Richards, L.; Lord, C.; Benton, M. L.; Capra, J. A.; Nordman, J. T.

10.1101/2022.04.05.487200 — molecular biology — Posted on 2022-04-05

3150 Comparative analysis about the structure of complete chloroplast genomes in genus Mangifera and accuracy verification about phylogenetic analysis based on gene ycf2 in genus level

Tang, Y.; Luo, S.; Zhang, Y.; Zhao, Y.; Li, R.; Guo, L.; Huang, G.; Gao, A.; Huang, J.; Yujuan Tang, Shixing Luo, Yu Zhang, Ying Zhao, Riwang Li, Limei Guo, Aiping Gao, Jianfeng Huang,

10.1101/2022.04.05.487216 — molecular biology — Posted on 2022-04-05

3151 CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever

Shu, B.; Ooi, J.; Tan, A.; Ng, T.-S.; Dejnirattisai, W.; Mongkolsapaya, J.; Fibriansah, G.; Shi, J.; Kostyuchenko, V.; Screaton, G.; Lok, S.-M.

10.1101/2022.04.04.487075 — molecular biology — Posted on 2022-04-05

3152 Microclimate is a strong predictor of the native and invasive plant-associated soil microbiota on San Cristobal Island, Galapagos archipelago

Schoenborn, A. A.; Yannarell, S. M.; MacVicar, C. T.; Medina, N. N. B.; Markellie, L. M.; Mitchell, H.; Bonham, K. S.; Leon-Reyes, A.; Klepac-Ceraj, V.; Shank, E. A.

10.1101/2022.04.05.487164 — microbiology — Posted on 2022-04-05

3153 A neuronal code for space in hippocampal coactivity dynamics independent of place fields

Levy, E. R. J.; Carrillo-Segura, S.; Redman, W. T.; Park, E. H.; Hurtado, J.; Fenton, A. A.

10.1101/2021.07.26.453856 — neuroscience — Posted on 2022-04-05

3154 Topographic projection of retinal ganglion cell axons at single-cell precision underlies retinotopy in the mouse superior colliculus

Molotkov, D.; Boissonnet, T.; Asari, H.

10.1101/2022.03.25.485790 — neuroscience — Posted on 2022-04-05

3155 Expectation violations enhance neuronal encoding of sensory information in mouse primary visual cortex

Tang, M. F.; Kheradpezhouh, E.; Lee, C. C.; Dickinson, J. E.; Mattingley, J. B.; Arabzadeh, E.

10.1101/2021.10.26.466004 — neuroscience — Posted on 2022-04-05

3156 In Vivo Multi-Day Calcium Imaging of CA1 Hippocampus in Freely Moving Rats Reveals a High Preponderance of Place Cells with Consistent Place Fields

Wirtshafter, H. S.; Disterhoft, J. F.

10.1101/2021.08.17.456533 — neuroscience — Posted on 2022-04-05

3157 Connectome-based predictions reveal developmental change in the functional architecture of sustained attention and working memory

Kardan, O.; Stier, A. J.; Cardenas-Inigues, C.; Pruin, J. C.; Schertz, K. E.; Deng, Y.; Chamberlain, T.; Meredith, W. J.; Zhang, X.; Bowman, J. E.; Lakhtakia, T.; Tindel, L.; Avery, E. W.; Lin, Q.; Yoo, K.; Chun, M. M.; Berman, M. G.; Rosenberg, M. D.

10.1101/2021.08.01.454530 — neuroscience — Posted on 2022-04-05

3158 Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans

Wirak, G. S.; Florman, J.; Alkema, M. J.; Connor, C. W.; Gabel, C. V.

10.1101/2021.07.07.451497 — neuroscience — Posted on 2022-04-05

3159 Accumulated 3-phosphoglycerate in darkness is a primary starting substrate for stepwise photosynthetic induction process in cyanobacteria

Tanaka, K.; Shirai, T.; Matsuda, M.; Kondo, A.; Hasunuma, T.

10.1101/2022.04.04.486922 — plant biology — Posted on 2022-04-05

3160 Nanoscale membrane curvature sorts lipid phases and alters lipid diffusion

Woodward, X.; Javanainen, M.; Fabian, B.; Kelly, C. V.

10.1101/2020.09.23.310086 — biophysics — Posted on 2022-04-05

3161 Cytostatic hypothermia and its impact on glioblastoma and survival

Enam, S. F.; Kilic, C. Y.; Huang, J.; Kang, B. J.; Chen, R.; Tribble, C. S.; Ilich, E.; Betancur, M. I.; Blocker, S. J.; Owen, S.; Buckley, A. F.; Lyon, J. G.; Bellamkonda, R. V.

10.1101/2021.03.25.436870 — bioengineering — Posted on 2022-04-05

3162 m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5' splice site

Parker, M. T.; Soanes, B. K.; Kusakina, J.; Larrieu, A.; Knop, K.; Joy, N.; Breidenbach, F.; Sherwood, A. V.; Barton, G. J.; Fica, S. M.; Davies, B.; Simpson, G. G.

10.1101/2022.04.05.487178 — molecular biology — Posted on 2022-04-05

3163 Cryo-EM Structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids

Li, Q.; Lin, C.; Li, H.; Li, X.; Sun, Q.

10.1101/2022.04.04.487086 — molecular biology — Posted on 2022-04-05

3164 Development of ultra-low-input nanoRibo-seq enables quantification of translational control, revealing broad uORF translation by subtype-specific neurons

Froberg, J. E.; Durak, O.; Macklis, J. D.

10.1101/2022.04.05.487068 — molecular biology — Posted on 2022-04-05

3165 Enhancing Prime Editing Efficiency and Flexibility with Tethered and Split pegRNAs

Feng, Y.; Wang, S.; Mo, Q.; Xiao, X.; Liu, P.; Ma, H.

10.1101/2022.04.05.487236 — molecular biology — Posted on 2022-04-05

3166 Description of Halopseudomonas maritima sp. nov., based on phylogenomic analysis

Kujur, R. R. A.; Das, S. K.

10.1101/2022.04.04.487078 — microbiology — Posted on 2022-04-05

3167 Single-cell transcriptomics to define Plasmodium falciparum stage-transition in the mosquito midgut

Mohammed, M.; Dziedziech, A.; Sekar, V.; Ernest, M.; Alves E Silva, T. L.; Balan, B.; Emami, S. N.; Biryukova, I.; Friedlander, M. R.; Jex, A.; Jacobs-Lorena, M.; Henriksson, J.; Vega-Rodriguez, J.; Ankarklev, J.

10.1101/2022.04.05.487115 — microbiology — Posted on 2022-04-05

3168 Distinct regions of H. pylori's bactofilin regulate protein interactions to control cell shape

Sichel, S. R.; Bratton, B. P.; Salama, N.

10.1101/2022.04.05.487110 — microbiology — Posted on 2022-04-05

3169 High-throughput molecular recording can determine the identity and biological activity of sequences within single cells

Tu, B.; Esvelt, K.

10.1101/2022.03.09.483646 — synthetic biology — Posted on 2022-04-05

3170 Determining significant correlation between pairs of extant characters in a small parsimony framework

Khandai, K.; Navarro-Martinez, C.; Smith, B.; Buonopane, R.; Byun, A. S.; Patterson, M. D.

10.1101/2021.01.26.428213 — evolutionary biology — Posted on 2022-04-05

3171 CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever

Shu, B.; Ooi, J.; Tan, A.; Ng, T.-S.; Dejnirattisai, W.; Mongkolsapaya, J.; Fibriansah, G.; Shi, J.; Kostyuchenko, V.; Screaton, G.; Lok, S.-M.

10.1101/2022.04.04.487075 — molecular biology — Posted on 2022-04-05

3172 Revealing determinants of translation efficiency via whole-gene codon randomisation and machine learning

Nieuwkoop, T.; Terlouw, B.; de Ridder, D.; Oost, J. v. d.; Claassens, N. J.

10.1101/2022.04.05.486962 — molecular biology — Posted on 2022-04-05

3173 Parental histone distribution at nascent strands controls homologous recombination during DNA damage tolerance

Gonzalez-Garrido, C.; Prado, F.

10.1101/2022.04.05.487148 — molecular biology — Posted on 2022-04-05

3174 TransCRISPR - sgRNA design tool for CRISPR/Cas9 experiments targeting transcription factor motifs

Wozniak, T.; Sura, W.; Kazimierska, M.; Kasprzyk, M. E.; Podralska, M.; Dzikiewicz-Krawczyk, A.

10.1101/2022.04.05.487109 — molecular biology — Posted on 2022-04-05

3175 FLAGELLAR MOTILITY DURING E. COLI BIOFILM FORMATION PROVIDES A COMPETITIVE DISADVANTAGE WHICH RECEDES IN THE PRESENCE OF CO-COLONIZERS.

Youssef, W. B.; Deforet, M.; Monmeyran, A.; HENRY, N.

10.1101/2022.04.05.487170 — microbiology — Posted on 2022-04-05

3176 Transmission of human influenza A virus in pigs selects for adaptive mutations on the HA gene

Mo, J.-s.; Abente, E. J.; Sutton, T. C.; Ferreri, L. M.; Geiger, G.; Gauger, P. C.; Perez, D. R.; Vincent, A. L.; Rajao, D. S.

10.1101/2022.04.04.487085 — microbiology — Posted on 2022-04-05

3177 The impact of PrsA over-expression on the Bacillus subtilis transcriptome during fed-batch fermentation of alpha-amylase production

Geissler, A.; Poulsen, L. D.; Doncheva, N. T.; Anthon, C.; Seemann, S. E.; Gonzalez-Tortuero, E.; Breüner, A.; Jensen, L. J.; Hjort, C.; Vinther, J.; Gorodkin, J.

10.1101/2022.04.05.487122 — microbiology — Posted on 2022-04-05

3178 Divergent LD-transpeptidase-independent effects of peptidoglycan carboxypeptidases on intrinsic ss-lactam and vancomycin resistance

Park, S. H.; Choi, U.; Ryu, S.-H.; Lee, H. B.; Lee, J.-W.; Lee, C.-R.

10.1101/2022.04.04.487088 — microbiology — Posted on 2022-04-05

3179 Tracing carbon metabolism with stable isotope metabolomics reveals the legacy of diverse carbon sources in soil

Wilhelm, R. C.; Barnett, S. E.; Swenson, T.; Youngblut, N. D.; Koechli, C. N.; Bowen, B. P.; Northen, T.; Buckley, D. H.

10.1101/2022.04.05.487192 — microbiology — Posted on 2022-04-05

3180 The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito

Roesch, F.; Cereghino, C.; Carrau, L.; Hardy, A.; Ribeiro-Filho, H.; Henrion Lacritick, A.; Koh, C.; Marano, J.; Bates, T. A.; Rai, P.; Chuong, C.; Akter, S.; Vallet, T.; Blanc, H.; Elliot, T.; Brown, A. M.; Michalak, P.; LeRoith, T.; Bloom, J.; Marques, R. E.; Saleh, M.-C.; Vignuzzi, M.; Weger-Lucarelli, J.

10.1101/2022.04.05.487100 — microbiology — Posted on 2022-04-05

3181 Single-deletion-mutant, third-generation rabies viral vectors allow nontoxic retrograde targeting of projection neurons with greatly increased efficiency

Jin, L.; Sullivan, H. A.; Zhu, M.; Lea, N. E.; Lavin, T. K.; Matsuyama, M.; Hou, Y.; Wickersham, I. R.

10.1101/2022.02.23.481706 — neuroscience — Posted on 2022-04-05

3182 Trait anxiety is associated with hidden state inference during aversive reversal learning

Zika, O.; Wiech, K.; Reinecke, A.; Browning, M.; Schuck, N. W.

10.1101/2022.04.01.483303 — neuroscience — Posted on 2022-04-05

3183 Glutathione-mediated plant response to high-temperature

Dard, A.; Weiss, A.; Bariat, L.; Picault, N.; Pontvianne, F.; Riondet, C.; Reichheld, J.-P.

10.1101/2022.03.28.485658 — plant biology — Posted on 2022-04-05

3184 Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids

Wintzinger, M.; Panta, M.; Miz, K.; Pragasam, A. D. P.; Sargent, M.; Peek, C.; Bass, J.; Molkentin, J.; Quattrocelli, M.

10.1101/2021.12.30.474468 — physiology — Posted on 2022-04-05

3185 The network of SARS-CoV-2-cancer molecular interactions and pathways

Erola, P.; Martin, R.; Gaunt, T. R.

10.1101/2022.04.04.487020 — cancer biology — Posted on 2022-04-05

3186 Time series analysis of SARS-CoV-2 genomes and correlations among highly prevalent mutations

Periwal, N.; Rathod, S. B.; Sarma, S.; Johar, G.; Jain, A.; Barnwal, R. P.; Srivastava, K. R.; Kaur, B.; Arora, P.; Sood, V.

10.1101/2022.04.05.487114 — bioinformatics — Posted on 2022-04-05

3187 Detecting DNA of novel fungal pathogens using ResNets and a curated fungi-hosts data collection

Bartoszewicz, J. M.; Nasri, F.; Nowicka, M.; Renard, B. Y.

10.1101/2021.11.30.470625 — bioinformatics — Posted on 2022-04-05

3188 The DNA-based global positioning system--a theoretical framework for large-scale spatial genomics

Greenstreet, L.; Afanassiev, A.; Kijima, Y.; Heitz, M.; Ishiguro, S.; King, S.; Yachie, N.; Schiebinger, G.

10.1101/2022.03.22.485380 — bioinformatics — Posted on 2022-04-05

3189 Pancreatic cancer risk predicted from disease trajectories using deep learning

Placido, D.; Yuan, B.; Hu, J. X.; Haue, A. D.; Chmura, P. J.; Yuan, C.; Kim, J.; Umeton, R.; Antell, G.; Chowdhury, A.; Franz, A.; Brais, L.; Andrews, E.; Marks, D.; Regev, A.; Kraft, P.; Wolpin, B. M.; Rosenthal, M.; Brunak, S.; Sander, C.

10.1101/2021.06.27.449937 — bioinformatics — Posted on 2022-04-05

3190 SampleQC: robust multivariate, multi-celltype, multi-sample quality control for single cell data

Macnair, W.; Robinson, M. D.

10.1101/2021.08.28.458012 — bioinformatics — Posted on 2022-04-05

3191 Resistor: an algorithm for predicting resistance mutations using Pareto optimization over multistate protein design and mutational signatures

Guerin, N.; Feichtner, A.; Stefan, E.; Kaserer, T.; Donald, B. R.

10.1101/2022.01.18.476733 — bioinformatics — Posted on 2022-04-05

3192 CaMKII binds both substrates and activators at the active site

Ozden, C.; Sloutsky, R.; Mitsugi, T.; Santos, N.; Agnello, E.; Gaubitz, C.; Foster, J.; Lapinskas, E.; Esposito, E. A.; Saneyoshi, T.; Kelch, B. A.; Garman, S. C.; Hayashi, Y.; Stratton, M.

10.1101/2020.10.25.354241 — biochemistry — Posted on 2022-04-05

3193 Spontaneous Chiral Symmetry Breaking in a Random Driven Chemical System

Pineros, W. D.; Tlusty, T.

10.1101/2021.08.23.457311 — biochemistry — Posted on 2022-04-05

3194 Evolution of Delta variant by non-Spike signature co-appearing mutations: trailblazer of COVID-19 disease outcome

Banerjee, A.; Mazumder, A.; Roy, J.; Majumdar, A.; Chatterjee, A.; Biswas, N. K.; Chawla-Sarkar, M.; Maitra, A.; Dutta, S.; Das, S.

10.1101/2022.04.05.487103 — genomics — Posted on 2022-04-05

3195 A framework for evaluating edited cell libraries created by massively parallel genome engineering

Cawley, S.; Abbate, E.; Abraham, C. G.; Alvarez, S.; Barber, M.; Bolte, S.; Bruand, J.; Church, D. M.; Davis, C.; Estes, M.; Federowicz, S.; Fox, R.; Gander, M. W.; Garst, A. D.; Gencer, G.; Halweg-Edwards, A. L.; Hardenbol, P.; Hraha, T.; Jain, S.; Johnson, C.; Juneau, K.; Krishnamurthy, N.; Lambert, S.; Leland, B.; Pearson, F.; Ray, J. C. J.; Sanada, C. D.; Shaver, T. M.; Shepherd, T. R.; Shorenstein, J.; Spindler, E. C.; Struble, C. A.; Swat, M. H.; Tanner, S.; Tian, T.; Wishart, K.; Graige, M. S.

10.1101/2021.09.23.458228 — genomics — Posted on 2022-04-05

3196 Quantity and quality of suitable matrices matter in reducing the negative effect of fragmentation on populations' extinction risk

Travassos-Britto, B.; Hohlenwerger, C.; Miranda, J. G. V.; Rocha, P. L. B. d.

10.1101/2020.08.10.244178 — ecology — Posted on 2022-04-05

3197 Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection

Oh, C.-k.; Nakamura, T.; Beutler, N.; Zhang, X.; Pina-Crespo, J.; Talantova, M.; Ghatak, S.; Trudler, D.; Carnevale, L. N.; McKercher, S. R.; Bakowski, M. A.; Diedrich, J. K.; Roberts, A. J.; Woods, A. K.; Chi, V.; Gupta, A. K.; Rosenfeld, M. A.; Kearns, F. L.; Casalino, L.; Shaabani, N.; Liu, H.; Wilson, I. A.; Amaro, R. E.; Burton, D. R.; Yates, J. R.; Becker, C.; Rogers, T. F.; Chatterjee, A. K.; Lipton, S. A.

10.1101/2022.04.05.487060 — microbiology — Posted on 2022-04-05

3198 Screening of SARS-CoV-2 Antivirals Through a Cell-Based RNA-Dependent RNA Polymerase (RdRp) Reporter Assay

Uppal, T.; Tuffo, K.; Khaiboullina, S.; Reganti, S.; PANDORI, M. C.; Verma, S. C.

10.1101/2022.04.04.486994 — microbiology — Posted on 2022-04-05

3199 Functional entry of Members of Venezuelan Equine Encephalitis Complex into host cells is dependent on clathrin-mediated endocytosis, in a pH-Dependent Manner

Ghietto, L. M.; Gil, P. I.; Olmos Quinteros, P.; Gomez, E.; Piris, F. M.; Kunda, P.; Contigiani, M.; Paglini, M. G.

10.1101/2022.03.11.483939 — microbiology — Posted on 2022-04-05

3200 Impact of prior infection on SARS-CoV-2 antibody responses in vaccinated long-term care facility staff

Gallichotte, E. N.; Nehring, M.; Stromberg, S.; Young, M. C.; Snell, A.; Daniels, J. B.; Pabilonia, K. L.; Vandewoude, S.; Ehrhart, N.; Ebel, G. D.

10.1101/2022.04.04.487083 — immunology — Posted on 2022-04-05

3201 Immunopharmacological evaluation of adjuvant efficacy of Monophosphoryl lipid-A and CpG ODN with SARS-CoV-2 RBD antigen

Sambyal, S.; Sravanthi, V.; Khatri, R.; Siddiqui, G.; Ahmed, S.; Samal, S.; Sampath Kumar, H. M.

10.1101/2022.04.04.486920 — immunology — Posted on 2022-04-05

3202 A Python Package for the Localization of Protein Modifications in Mass Spectrometry Data

Barente, A. S.; Villen, J.

10.1101/2022.04.04.487044 — bioinformatics — Posted on 2022-04-05

3203 Methacrylic acid-based biomaterials promote peripheral innervation in the subcutaneous space of mice

Androschuk, A. M.; Tam, T. H.; Mahou, R.; Lo, C.; Salter, M. W.; Sefton, M. V.

10.1101/2022.04.03.486876 — bioengineering — Posted on 2022-04-05

3204 Substance P and adenosine signaling pathways regulate exosomal sorting of miR-21 in colonic epithelial cells

Wani, S.; Law, I. K. M.; Bugwadia, A. K.; Hoffman, J. M.; Pothoulakis, C.

10.1101/2022.03.30.486482 — cell biology — Posted on 2022-04-05

3205 Neural systems underlying RDoC social constructs: An activation likelihood estimation meta-analysis

Lobo, R. P.; Bottenhorn, K. L.; Riedel, M. C.; Toma, A. I.; Hare, M. M.; Smith, D. D.; Moor, A. C.; Cowan, I. K.; Valdes, J. A.; Bartley, J. E.; Salo, T.; Boeving, E. R.; Pankey, B.; Sutherland, M. T.; Musser, E. D.; Laird, A. R.

10.1101/2022.04.04.487016 — neuroscience — Posted on 2022-04-05

3206 High-level motor planning allows flexible walking at different gait patterns in a neuromechanical model

Ramadan, R.; Meischein, F.; Reimann, H.

10.1101/2022.04.04.486949 — neuroscience — Posted on 2022-04-05

3207 Mice expressing P301S mutant human tau have deficits in interval timing

Khandelwal, V.; Larson, T.; Weber, M. A.; Leidinger, M. R.; Meyerholz, D. K.; Narayanan, N.; Zhang, Q.

10.1101/2022.04.04.487032 — neuroscience — Posted on 2022-04-05

3208 Tissue-wide Genetic and Cellular Landscape Shapes the Execution of Sequential PRC2 Functions in Neural Stem Cell Lineage Progression

Amberg, N.; Pauler, F. M.; Streicher, C.; Hippenmeyer, S.

10.1101/2022.04.04.487003 — neuroscience — Posted on 2022-04-05

3209 Microglia Detect Externalized Phosphatidylserine on Synapses for Elimination via TREM2 in Alzheimer's Disease Models

Rueda-Carrasco, J.; Sokolova, D.; Lee, S.-E.; Childs, T.; Jurcakova, N.; De Schepper, S.; Ge, J. Z.; Lachica, J. I.; Toomey, C. E.; Freeman, O. J.; Hardy, J.; Stevens, B.; Lashley, T.; Chang, S.; Hong, S.

10.1101/2022.04.04.486424 — neuroscience — Posted on 2022-04-05

3210 Reduced stroke outcome in old-aged female mice maintained on a dietary vitamin B12 deficiency

Poole, J.; Jasbi, P.; Pascual, A.; North, S.; Kwatra, N.; Weissig, V.; Gu, H.; Bottiglieri, T.; Jadavji, N. M.

10.1101/2022.04.04.487028 — physiology — Posted on 2022-04-05

3211 mRNAid, an Open-Source Platform for Therapeutic mRNA Design and Optimization Strategies

Vostrosablin, N.; Lim, S.; Gopal, P.; Brazdilova, K.; Parajuli, S.; Wei, X.; Gromek, A.; Spale, M.; Muzdalo, A.; Yeo, C.; Wardyn, J.; Mejzlik, P.; Henry, B.; Partridge, A. W.; Bitton, D. A.

10.1101/2022.04.04.486952 — bioinformatics — Posted on 2022-04-05

3212 Small silencing RNAs expressed from W-linked retrocopies of Masculinizer target the male-determining gene PxyMasc during female sex determination in the Diamondback moth Plutella xylostella

Harvey-Samuel, T.; Xu, X.; Anderson, M. E.; Carabajal Paladino, L.; Kumar Purusothaman, D.; Norman, V.; Reitmayer, C. M.; You, M.; Alphey, L.

10.1101/2022.04.04.486979 — developmental biology — Posted on 2022-04-05

3213 Application of light-sheet mesoscopy to image host-pathogen interactions in intact organs

Battistella, E.; Quintana, J. F.; McConnell, G.

10.1101/2022.04.04.486945 — immunology — Posted on 2022-04-05

3214 Cognitive dysfunction and anxiety resulted from synaptic downscaling, hippocampal atrophy and ventricular enlargement in i.c.v. streptozotocin injected male Wistar rats

Roy, A.; Sharma, S.; Nag, T. C.; Katyal, J.; Gupta, Y. K.; Jain, S.

10.1101/2022.04.04.486747 — neuroscience — Posted on 2022-04-05

3215 Gut microbiome-linked metabolites in the pathobiology of depression and anxiety - a role for bile acids

MahmoudianDehkordi, S.; Bhattacharyya, S.; Brydges, C. R.; Jia, W.; Fiehn, O.; Rush, A. J.; Dunlop, B. W.; Kaddurah-Daouk, R.

10.1101/2022.04.04.485514 — neuroscience — Posted on 2022-04-05

3216 ASTF1, an AP2/ERF-family transcription factor and ortholog of cultivated tomato LEAFLESS, is required for acylsugar biosynthesis

Mandal, S.; Rezenom, Y. H.; McKnight, T. D.

10.1101/2022.04.04.487036 — plant biology — Posted on 2022-04-05

3217 Ralstonia solanacearum effector RipAF1 ADP-ribosylates host FBN1 to induce resistance against bacterial wilt

Wu, W.; Luo, X.; Chen, X.; Wang, L.; Wang, K.; Tian, S.; Tong, Z.; Zhao, T.; Fan, X.; Zhuo, T.; Hu, X.; Zou, H.

10.1101/2022.04.04.487053 — plant biology — Posted on 2022-04-05

3218 Electron tomography analysis of the prolamellar body and its transformation into grana thylakoids in the cryofixed Arabidopsis cotyledon

Liang, Z.; Yeung, W.-T.; Mai, K. K.; Ma, J.; Liu, Z.; Chong, Y.-L. F.; Cai, X.; Kang, B.-H.

10.1101/2022.04.04.487035 — plant biology — Posted on 2022-04-05

3219 Increased adipose tissue indices of androgen catabolism and aromatization in women with metabolic dysfunction

Ostinelli, G.; Laforest, S.; Denham, S.; Gauthier, M.-F.; Labelle, V. D.; Scott, E.; Hould, F. S.; Marceau, S.; Homer, N. Z. M.; Begin, C.; Andrew, R.; Tchernof, A.

10.1101/2022.04.04.486987 — physiology — Posted on 2022-04-05

3220 3'UTR-dependent dynamic changes in TP53 mRNA localization regulate p53 tumor suppressor activity

Hu, L.; Misra, S.; Karim, B.; Kuhn, S.; Salotti, J.; Basu, S.; Martin, N.; Saylor, K.; Johnson, P. F.

10.1101/2022.04.04.487038 — cancer biology — Posted on 2022-04-05

3221 Characterizing the extracellular matrix transcriptome of cervical, endometrial, anduterine cancers

Cook, C. J.; Miller, A. E.; Barker, T.; Di, Y.; Fogg, K.

10.1101/2022.04.04.486998 — cancer biology — Posted on 2022-04-05

3222 Molecular-Dynamics Simulation Methods for Macromolecular Crystallography

Wych, D. C.; Aoto, P. C.; Vu, L.; Wolff, A. M.; Mobley, D. L.; Fraser, J. S.; Taylor, S. S.; Wall, M. E.

10.1101/2022.04.04.486986 — biophysics — Posted on 2022-04-05

3223 DeepVelo: Deep Learning extends RNA velocity to multi-lineage systems with cell-specific kinetics

Cui, H.; Maan, H.; Wang, B.

10.1101/2022.04.03.486877 — bioinformatics — Posted on 2022-04-05

3224 A Deep Learning Method for MiRNA/IsomiR Target Detection

Talukder, A.; Zhang, W.; Li, X.; Hu, H.

10.1101/2022.04.04.487002 — bioinformatics — Posted on 2022-04-05

3225 recolorize: improved color segmentation of digital images (for people with other things to do)

Weller, H. I.; Hiller, A. E.; Van Belleghem, S. M.; Lord, N. P.

10.1101/2022.04.03.486906 — bioinformatics — Posted on 2022-04-05

3226 Systematic classification error profoundly impacts inference in high-depth Whole Genome Shotgun Sequencing datasets

Johnson, J. B.; Sun, S.; Fodor, A.

10.1101/2022.04.04.487034 — bioinformatics — Posted on 2022-04-05

3227 Microenvironmental engineering improves the self-organization of patterned microvascular networks

Cabral, K. A.; Srivastava, V.; Coyle, M. C.; Stashko, C.; Weaver, V.; Gartner, Z. J.

10.1101/2022.04.04.487052 — bioengineering — Posted on 2022-04-05

3228 Active vision during prey-capture in wild marmoset monkeys

Ngo, V.; Miller, C.; Gorman, J.; De La Fuente, M. F.; Souto, A.; Schiel, N.

10.1101/2022.04.01.486794 — animal behavior and cognition — Posted on 2022-04-05

3229 Full-length dystrophin is expressed across human tissues and DMD downregulation commonly occurring in tumours coincides with Duchenne-like molecular alterations

Alnassar, N.; Borczyk, M.; Tsagkogeorga, G.; Korostynski, M.; Han, N.; Gorecki, D. C.

10.1101/2022.04.04.486990 — genetics — Posted on 2022-04-05

3230 NUMT PARSER: automated identification and removal of nuclear mitochondrial pseudogenes (numts) for accurate mitochondrial genome reconstruction in Panthera

de Flamingh, A.; Rivera-Colon, A. G.; Gnoske, T.; Kerbis Peterhans, J. C.; Catchen, J. M.; Malhi, R.; Roca, A. L.

10.1101/2022.04.04.487049 — evolutionary biology — Posted on 2022-04-05

3231 Community adaptation to temperature explains abrupt soil bacterial community shift along a geothermal gradient on Iceland

Weedon, J.; Baath, E.; Rijkers, R.; Reischke, S.; Sigurdsson, B. D.; Oddsdottir, E.; van Hal, J.; Aerts, R.; Janssens, I.; van Bodegom, P.

10.1101/2022.04.04.486966 — ecology — Posted on 2022-04-05

3232 Colouring coral larvae for tracking dispersal

Doropoulos, C.; Roff, G.

10.1101/2022.04.04.485987 — ecology — Posted on 2022-04-05

3233 Transcriptional profiling from whole embryos to single neuroblast lineages in Drosophila

Seroka, A. P.; Lai, S.-L.; doe, c.

10.1101/2022.04.04.487012 — developmental biology — Posted on 2022-04-05

3234 Detection and molecular characterization of a phytoplasma associated with Cucumber (Cucumis sativus) and its first report from India

Muttappagol, M.; H. D., V. K.; Hiremath, S.; M., N.; C. R., J. B.; K. S., S.; V, V.; Reddy, C. N. L.

10.1101/2022.04.04.486938 — molecular biology — Posted on 2022-04-05

3235 A one-step CRISPR-based strategy for endogenous gene tagging in Drosophila melanogaster

Xiao, Y.; Yuan, Y.; Yadlapalli, S.

10.1101/2022.04.04.487042 — molecular biology — Posted on 2022-04-05

3236 Single-cell transcriptomics reveal hyperacute cytokine and immune checkpoint axis in patients with poor neurological outcomes after cardiac arrest

Tamura, T.; Cheng, C.; Chen, W.; Merriam, L. C.; Pinilla-Vera, M.; Varon, J.; Hou, P. C.; Lawler, P. R.; Oldham, W. M.; Seethala, R. R.; Tesfaigzi, Y.; Weissman, A. J.; Baron, B. M.; Ichinose, F.; Berg, K. M.; Bohula, E. A.; Morrow, D. A.; Chen, X.; Kim, E. Y.; Immunology of Cardiac Arrest Network (I-CAN),

10.1101/2022.04.04.487033 — immunology — Posted on 2022-04-05

3237 Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Froehlich, A.; olde Heuvel, F.; Rehman, R.; Krishnamurthy, S. S.; Li, S.; Li, Z.; Bayer, D.; Conquest, A.; Hertle, A. M.; Ludolph, A. C.; Huber-Lang, M.; Boeckers, T. M.; Knoell, B.; Morganti-Kossmann, M. C.; Bading, H.; Roselli, F.

10.1101/2022.04.03.486874 — neuroscience — Posted on 2022-04-05

3238 All-optical visualization of specific molecules in the ultrastructural context of brain tissue

10.1101/2022.04.04.486901 — neuroscience — Posted on 2022-04-05

3239 Overactivation of a sleep-active neuron decouples survival from the need to sleep

Busack, I.; Bringmann, H.

10.1101/2022.04.03.486914 — neuroscience — Posted on 2022-04-05

3240 Dichotomic Regulation of Striatal Plasticity by Dynorphin

Yang, R.; Lalchandani, R. R.; Hwang, F.-J.; Bloodgood, D. W.; Kong, D.; Ding, J. B.

10.1101/2022.04.04.487051 — neuroscience — Posted on 2022-04-05

Wong, R. K.; Selvanayagam, J.; Johnston, K.; Everling, S.

10.1101/2022.04.04.487026 — neuroscience — Posted on 2022-04-05

3242 Effect of LSD and music on the time-varying brain dynamics

Adamska, I.; Finc, K.

10.1101/2022.04.04.486673 — neuroscience — Posted on 2022-04-05

3243 Perivascular SPP1 Mediates Microglial Engulfment of Synapses in Alzheimers Disease Models

De Schepper, S.; Ge, J. Z.; Crowley, G.; Ferreira, L. S.; Garceau, D.; Toomey, C. E.; Sokolova, D.; Childs, T.; Lashley, T.; Burden, J. J.; Jung, S.; Sasner, M.; Frigerio, C. S.; Hong, S.

10.1101/2022.04.04.486547 — neuroscience — Posted on 2022-04-05

3244 Nuclear inhibitor of protein phosphatase 1 (NIPP1) regulates CNS tau phosphorylation and myelination during development

McKee, C.; Shrager, P.; Mazumder, A.; Ganguly, A.; Mayer, A.; Foley, K.; Ward, N.; Youngman, M.; Bollen, M.; Hou, H.; Xia, H.

10.1101/2022.04.02.486849 — neuroscience — Posted on 2022-04-05

3245 Sloppiness: fundamental study, new formalism and quantification

Jagadeesan, P.; Raman, K.; Tangirala, A. K.

10.1101/2022.04.02.486816 — systems biology — Posted on 2022-04-05

3246 The catalytic domain of cellulose synthase (CESA) is involved in vesicle trafficking and protein dynamics

Huang, L.; Zhang, W.; Li, X.; Staiger, C. J.; Zhang, C.

10.1101/2022.04.04.487015 — plant biology — Posted on 2022-04-05

3247 Loss of HOXA10 causes endometrial hyperplasia progressing to endometrial cancer

Mishra, A.; Ganguli, N.; Majumdar, S.; Modi, D.

10.1101/2022.04.04.486936 — cancer biology — Posted on 2022-04-05

3248 Tumor spheroids accelerate persistently invading cancer cells

Audoin, M.; Soegaard, M. T.; Jauffred, L.

10.1101/2022.04.04.486939 — biophysics — Posted on 2022-04-05

3249 Talin-drug interaction reveals a key molecular determinant for biphasic mechanical effect: studied under single-molecule resolution

Chakraborty, S.; Bhatt, M.; Chowdhury, D.; Chaudhuri, D.; Haldar, S.

10.1101/2022.04.04.486950 — biophysics — Posted on 2022-04-05

3250 DeepToA: An Ensemble Deep-Learning Approach to Predicting the Theater of Activity of a Microbiome

Zeng, W.; Gautam, A.; Huson, D.

10.1101/2022.04.04.486969 — bioinformatics — Posted on 2022-04-05

3251 Principal component analysis- and tensor decomposition-based unsupervised feature extraction to select more reasonable differentially methylated cytosines: Optimization of standard deviation versus state-of-the-art methods

Taguchi, Y.-h.; Turki, T.

10.1101/2022.04.02.486807 — bioinformatics — Posted on 2022-04-05

3252 Noncoding RNA's competing endogenous gene pair as motif in serous ovarian cancer

Cheng, L.; Zheng, X.; Leung, K.-S.; Wong, M.-H.

10.1101/2022.04.04.486923 — bioinformatics — Posted on 2022-04-05

3253 Engineering Proprioceptive Implants via Surgical and Regenerative Approaches: Preliminary Interpretations

Das, S.; Sarma, H. D.; Bellare, J.

10.1101/2022.04.03.486912 — bioengineering — Posted on 2022-04-05

3254 A Self-Purifying Microfluidic System for Identifying Drugs Acting Against Adult Schistosomes

Girod, V.; Ghoris, M.-J.; Caby, S.; Dissous, C.; Melnyk, O.; Senez, V.; Vicogne, J.

10.1101/2022.04.04.486714 — bioengineering — Posted on 2022-04-05

3255 Remodeling of gene regulatory networks underlying thermogenic stimuli-induced adipose beiging

Lee, S.; Benvie, A. M.; Park, H. G.; Spektor, R.; Harlan, B.; Brenna, J. T.; Berry, D.; Soloway, P.

10.1101/2022.04.03.486732 — genomics — Posted on 2022-04-05

3256 The genetic architectures of vine and skin maturity in tetraploid potato

Caraza-Harter, M. V.; Endelman, J. B.

10.1101/2022.04.04.486897 — genetics — Posted on 2022-04-05

3257 Systematic identification of unannotated ORFs in Drosophila reveals evolutionary heterogeneity

Zheng, E. B.; Zhao, L.

10.1101/2022.04.04.486978 — evolutionary biology — Posted on 2022-04-05

3258 Prey resources are more important than climatic conditions for predicting the distribution of a broad-ranged apex predator

Sutton, L. J.; Anderson, D. L.; Franco, M.; McClure, C. J.; Miranda, E. B.; Vargas, F. H.; Vargas Gonzalez, J. d. J.; Puschendorf, R.

10.1101/2022.04.04.486974 — ecology — Posted on 2022-04-05

3259 Climate change will redefine taxonomic, functional, and phylogenetic diversity patterns of Odonata in space and time

Cancellario, T.; Miranda, R.; Baquero, E.; Fontaneto, D.; Martinez, A.; Mammola, S.

10.1101/2022.04.04.486993 — ecology — Posted on 2022-04-05

3260 T cell-mediated development of stromal fibroblasts with an immune-enhancing chemokine profile

Yan, R.; Fearon, D. T.

10.1101/2022.04.03.486884 — immunology — Posted on 2022-04-05

3261 Breast cancer stem cell-derived tumors escape from γδ T cell immunosurveillance in vivo by modulating γδ T cell ligands

Raute, K.; Strietz, J.; Andrieux, G.; Thomas, O. S.; Kistner, K. M.; Zintchenko, M.; Aichele, P.; Zhou, H.; Weber, W.; Boerries, M.; Swamy, M.; Maurer, J.; Minguet, S.

10.1101/2022.04.04.486931 — immunology — Posted on 2022-04-05

3262 Kidins220 regulates the development of B cells bearing the {lambda} light chain

Schaffer, A.-M.; Fiala, G. J.; Hils, M.; Natali, E.; Babrak, L.; Herr, L. A.; Rizzi, M.; Miho, E.; Schamel, W.; Minguet, S.

10.1101/2022.04.04.486937 — immunology — Posted on 2022-04-05

3263 Firing behavior of single motor neurons of the tibialis anterior in human walking as non-invasively revealed by HDsEMG decomposition

Yokoyama, H.; Kaneko, N.; Sasaki, A.; Saito, A.; Nakazawa, K.

10.1101/2022.04.03.486869 — neuroscience — Posted on 2022-04-05

3264 Functional coupling of the mesencephalic locomotor region and V2a reticulospinal neurons driving forward locomotion

Carbo-Tano, M.; Lapoix, M.; Jia, X.; Auclair, F.; Dubuc, R.; Wyart, C.

10.1101/2022.04.01.486703 — neuroscience — Posted on 2022-04-05

3265 DomeVR: A setup for experimental control of an immersive dome virtual environment created with Unreal Engine 4

Shapcott, K. A.; Weigand, M.; Glukhova, I.; Havenith, M. N.; Scholvinck, M. L.

10.1101/2022.04.04.486889 — neuroscience — Posted on 2022-04-05

3266 Information theory characteristics improve the prediction of lithium response in bipolar disorder patients using an SVM classifier

Tripathi, U.; Mizrahi, L.; Alda, M.; Falkovich, G.; Stern, S.

10.1101/2022.04.04.486856 — neuroscience — Posted on 2022-04-05

3267 The influence of stereopsis on visual saliency in a proto-object based model of selective attention

Uejima, T.; Mancinelli, E.; Niebur, E.; Etienne-Cummings, R.

10.1101/2022.04.04.486976 — neuroscience — Posted on 2022-04-05

3268 Bidirectional modulation of neuronal excitability via ionic actuation of potassium

Verardo, C.; Jolivet, R.; Mele, L. J.; Giugliano, M.; Palestri, P.

10.1101/2022.04.03.486896 — neuroscience — Posted on 2022-04-05

3269 The Insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice

Wang, Y.; Lopez-Bellido, R.; Huo, X.; Kavelaars, A.; Galko, M.

10.1101/2022.04.02.486841 — neuroscience — Posted on 2022-04-05

3270 Chronic hM3Dq-DREADD mediated chemogenetic activation of parvalbumin-positive inhibitory interneurons in postnatal life alters anxiety and despair-like behavior in adulthood in a task and sex-dependent manner

Banerjee, T.; Pati, S.; Tiwari, P.; Vaidya, V. A.

10.1101/2022.04.04.487022 — neuroscience — Posted on 2022-04-05

3271 Laboratory evolution of synthetic electron transport system variants reveals a larger metabolic respiratory system and its plasticity

Anand, A.; Patel, A.; Chen, K.; Olson, C. A.; Phaneuf, P. V.; Lamoureux, C.; Hefner, Y.; Szubin, R.; Feist, A.; Palsson, B.

10.1101/2022.04.04.487013 — systems biology — Posted on 2022-04-05

3272 A paracrine circuit of IL-1b/IL-1R1 between myeloid and tumor cells drives glioblastoma progression

Chen, Z.; Giotti, B.; Kaluzova, M.; Herting, C.; Pinero, G.; vallcorba, m. p.; Cristea, S.; Ross, J. L.; Ackley, J.; Maximov, V.; Szulzewsky, F.; Marquez-Ropero, M.; Angione, A.; Nichols, N.; Tsankkova, N.; Michor, F.; Shayakhmetov, D. M.; Gutmann, D. H.; Tsankov, A. M.; Hambardzumyan, D.

10.1101/2022.04.03.486888 — cancer biology — Posted on 2022-04-05

3273 Drug addiction mutations unveil a methylation ceiling in EZH2-mutant lymphoma

Kwok, H. S.; Freedy, A. M.; Siegenfeld, A. P.; Morriss, J. W.; Waterbury, A. L.; Kissler, S. M.; Liau, B.

10.1101/2022.04.04.486977 — cancer biology — Posted on 2022-04-05

3274 A multiscale whole-cell theory for mechano-sensitive migration on viscoelastic substrates

Shu, W.; Kaplan, C. N.

10.1101/2022.04.01.486783 — biophysics — Posted on 2022-04-05

3275 Elongated exons encoding disordered regions expedited eukaryotic evolution

Homma, K.; Fukuch, S.; Noguchi, T.; Anbo, H.

10.1101/2022.04.03.486857 — bioinformatics — Posted on 2022-04-05

3276 Communication-Efficient Cluster Scalable Genomics Data Processing Using Apache Arrow Flight

Ahmad, T.

10.1101/2022.04.01.486780 — bioinformatics — Posted on 2022-04-05

3277 epiAneufinder: identifying copy number variations from single-cell ATAC-seq data

Ramakrishnan, A.; Symeonidi, A.; Hanel, P.; Schubert, M.; Colome-Tatche, M.

10.1101/2022.04.03.485795 — bioinformatics — Posted on 2022-04-05

3278 Single-cell multimodal modeling with deep parametric inference

Hu, H.

10.1101/2022.04.04.486878 — bioinformatics — Posted on 2022-04-05

3279 Motifizer: a tool for parsing high-throughput sequencing datasets and quantitative comparative analyses of transcription factor-binding sites

Khan, S.; Bhattacharjee, A. S.; Badhe, P.; Dongaonkar, C.; Gaglani, Y.

10.1101/2022.04.03.486862 — bioinformatics — Posted on 2022-04-05

3280 Cellpose 2.0: how to train your own model

Stringer, C.; Pachitariu, M.

10.1101/2022.04.01.486764 — bioinformatics — Posted on 2022-04-05

3281 A computational modeling of primary-microRNA expression

Zheng, H.; Wang, S.; Li, X.; Hu, H.

10.1101/2022.04.04.486960 — bioinformatics — Posted on 2022-04-05

3282 Machine Learning Classification Reveals Robust Morphometric Biomarker of Glial and Neuronal Arbors

Akram, M. A.; Wei, Q.; Ascoli, G.

10.1101/2022.04.02.486839 — bioengineering — Posted on 2022-04-05

3283 Lumbar time-varying muscle synergies in trunk flexion and bending movements at different velocities

Bagheri Rouchi, M.; Davoudi, M.; Meftahi, N.; Rashedi, E.; Parnianpour, M.; Khalaf, K.

10.1101/2022.04.03.486861 — bioengineering — Posted on 2022-04-05

3284 Behavioral dysregulation and monoaminergic deficits precede memory impairments in human tau-overexpressing (htau) mice

Khan, K. M.; Selvakumar, G. P.; Balasubramanian, N.; Wang, R.; Pierson, S.; Hefti, M.; Marcinkiewcz, C. A.

10.1101/2022.04.03.486898 — animal behavior and cognition — Posted on 2022-04-05

3285 Evolutionary responses of a reef-building coral to climate change at the end of the last glacial maximum

Zhang, J.; Richards, Z. T.; Adam, A. A. S.; Chan, C. X.; Shinzato, C.; Gilmour, J.; Thomas, L.; Strugnell, J. M.; Miller, D. J.; Cooke, I. R.

10.1101/2022.04.02.486852 — evolutionary biology — Posted on 2022-04-05

3286 Bird community structure in a mixed forest-production landscape in the northern Western Ghats, India

Munje, A.; Kumar, A.

10.1101/2022.04.04.486917 — ecology — Posted on 2022-04-05

3287 Persistent pervasive transcription in RNA exosome depleted oocytes results in loss of female fertility

Wu, D.; Dean, J.

10.1101/2022.04.02.486818 — developmental biology — Posted on 2022-04-05

3288 Stochastic analysis of frequency bandwidth and noise attenuation in neurotransmission

Vahdat, Z.; Singh, A.

10.1101/2022.04.01.486751 — neuroscience — Posted on 2022-04-05

3289 Brain-heart interactions are optimized across the respiratory cycle via interoceptive attention

Zaccaro, A.; Perrucci, M. G.; Parrotta, E.; Costantini, M.; Ferri, F.

10.1101/2022.04.02.486808 — neuroscience — Posted on 2022-04-05

3290 Separation of NaV Subtypes in the Axon InitialSegment can Impede or Promote Backpropagation

Barlow, B. S.; Longtin, A.; Joos, B.

10.1101/2022.04.01.486760 — neuroscience — Posted on 2022-04-05

3291 Microstructural alterations in tract development in college football: a longitudinal diffusion MRI study

Goubran, M.; Mills, B. D.; Georgiadis, M.; Karimpoor, M.; Mouchawar, N.; Sami, S.; Dennis, E. L.; Mitchell, L. A.; Douglas, D.; DiGiacomo, P.; Rosenberg, J.; Grant, G.; Wintermark, M.; Zeineh, M.

10.1101/2022.04.01.486632 — neuroscience — Posted on 2022-04-05

3292 Functional Cell Types in the Mouse Superior Colliculus

Li, Y.; Meister, M.

10.1101/2022.04.01.486789 — neuroscience — Posted on 2022-04-05

3293 An open-source, ready-to-use and validated ripple detector plugin for the Open Ephys GUI

Sousa, B. M. d.; de Oliveira, E. F.; Beraldo, I. J. d. S.; Polanczyk, R. S.; Leite, J. P.; Lopes Aguiar, C.

10.1101/2022.04.01.486754 — neuroscience — Posted on 2022-04-05

3294 Cue-driven motor planning facilitates express visuomotor responses in human arm muscles

Contemori, S.; Loeb, G. E.; Corneil, B. D.; Wallis, G.; Carroll, T. J.

10.1101/2022.04.02.486810 — neuroscience — Posted on 2022-04-05

3295 Speed-dependent biomechanical changes vary across individual gait metrics post-stroke relative to neurotypical adults

Kettlety, S. A.; Finley, J. M.; Reisman, D. S.; Schweighofer, N.; Leech, K. A.

10.1101/2022.04.01.486769 — neuroscience — Posted on 2022-04-05

3296 Tackling polypharmacology of kinase inhibitors by transcription factor activity profiling.

Medvedev, A.; Makarov, S.; Medvedeva, L. A.; Martsen, E.; Gorman, K. L.; Lin, B.; Makarov, S. S.

10.1101/2022.04.03.486887 — pharmacology and toxicology — Posted on 2022-04-05

3297 LENS - Landscape of Effective Neoantigens Software

Vensko, S. P.; Olsen, K.; Bortone, D. S.; Smith, C. C.; Chai, S.; Rubinsteyn, A.; Vincent, B.

10.1101/2022.04.01.486738 — cancer biology — Posted on 2022-04-05

3298 GenMPI: Cluster Scalable Variant Calling forShort/Long Reads Sequencing Data

Ahmad, T.

10.1101/2022.04.01.486779 — bioinformatics — Posted on 2022-04-05

3299 Factors regulating translation coupled mRNA degradation in yeast

Basu, S.; Maiti, R.; Hait, S.; Chaudhuri, A. R.; Kundu, S.

10.1101/2022.04.01.486758 — bioinformatics — Posted on 2022-04-05

3300 Nonlinear Parameter and State Estimation Approach in End-stage Kidney Disease Patients

Abohtyra, R.; Vincent, T. L.

10.1101/2022.04.02.486844 — bioengineering — Posted on 2022-04-05

3301 Cellular and Molecular Organization of the Rhesus Macaque Dorsal Horn with a Comparison to Mouse

Arokiaraj, C.; Kleyman, M.; Chamessian, A.; Shiers, S.; Kang, B.; Kennedy, M.; Chen, Y.; Dum, R.; Patterson, R.; Lewis, D.; Qadri, Y.; Levine, A.; Price, T.; Pfenning, A.; Seal, R.

10.1101/2022.04.01.486135 — neuroscience — Posted on 2022-04-05

3302 Visuo-tactile integration in texture perception: A replication and extension study

Kangur, K.; Giesel, M.; Harris, J. M.; Hesse, C.

10.1101/2022.04.01.486675 — neuroscience — Posted on 2022-04-05

3303 Trait anxiety is associated with hidden state inference during aversive reversal learning

Zika, O.; Wiech, K.; Reinecke, A.; Browning, M.; Schuck, N. W.

10.1101/2022.04.01.483303 — neuroscience — Posted on 2022-04-05

3304 Functional autapses form in striatal parvalbumin interneurons but not medium spiny neurons

Wang, X.; Shu, Z.; He, Q.; Zhang, X.; Li, L.; Zhang, X.; Li, L.; Xiao, Y.; Peng, B.; Guo, F.; Wang, D.-H.; Shu, Y.

10.1101/2022.04.01.486668 — neuroscience — Posted on 2022-04-05

3305 Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of over 3,000 dogs: determining the optimal age to initiate cancer screening in canine patients

Rafalko, J. M.; Kruglyak, K. M.; McCleary-Wheeler, A. L.; Goyal, V.; Phelps-Dunn, A.; Wong, L. K.; Warren, C. D.; Brandstetter, G.; Rosentel, M. C.; McLennan, L. M.; Grosu, D. S.; Chibuk, J.; Tsui, D. W.; Chorny, I.; Flory, A.

10.1101/2022.03.30.486448 — cancer biology — Posted on 2022-04-05

3306 Reproducible stool metagenomic biomarkers linked to the melanoma immunotherapy positive outcome

Olekhnovich, E. I.; Ivanov, A. B.; Babkina, A. A.; Sokolov, A. A.; Ulyantsev, V. I.; Fedorov, D. E.; Ilina, E. N.

10.1101/2022.04.01.486538 — bioinformatics — Posted on 2022-04-05

3307 Estimates of in vivo turnover numbers by simultaneously considering data from multiple conditions improve metabolic predictions

Wendering, P.; Arend, M.; Nikoloski, Z.

10.1101/2022.04.01.486742 — bioinformatics — Posted on 2022-04-05

3308 Newfoundland and Labrador: A mosaic founder population of an Irish and British diaspora from 300 years ago.

10.1101/2022.04.01.486593 — genetics — Posted on 2022-04-05

3309 phenopype: A phenotyping pipeline for Python

Luerig, M. D.

10.1101/2021.03.17.435781 — evolutionary biology — Posted on 2022-04-05

3310 Factors determining distributions of rainforest Drosophila shift from interspecific competition to high temperature with decreasing elevation

Chen, J.; Lewis, O.

10.1101/2022.04.01.486700 — ecology — Posted on 2022-04-05

3311 Cochlear theta activity oscillates in phase opposition during interaural attention

Koehler, M. H. A.; Weisz, N.

10.1101/2022.02.21.481289 — neuroscience — Posted on 2022-04-05

Rysop, A. U.; Schmitt, L.-M.; Obleser, J.; Hartwigsen, G.

10.1101/2021.12.02.470763 — neuroscience — Posted on 2022-04-05

3313 Bmal1-knockout mice exhibit reduced cocaine-seeking behaviour and cognitive impairments

Castro-Zavala, A.; Alegre-Zurano, L.; Cantacorps, L.; Gallego-Landin, I.; Welz, P.-S.; Aznar Benitah, S.; Valverde, O.

10.1101/2022.04.01.486740 — neuroscience — Posted on 2022-04-05

3314 Decision heuristics in contexts exploiting intrinsic skill

Dundon, N. M.; Colas, J. T.; Garrett, N.; Babenko, V.; Rizor, E.; Yang, D.; MacNamara, M.; Petzold, L.; Grafton, S. T.

10.1101/2022.04.01.486746 — neuroscience — Posted on 2022-04-05

3315 NETISCE: A Network-Based Tool for Cell Fate Reprogramming

Marazzi, L.; Shah, M.; Balakrishnan, S.; Patil, A.; Vera-Licona, P.

10.1101/2021.12.30.474582 — systems biology — Posted on 2022-04-05

3316 Bio-hybrid micro-swimmers propelled by flagella isolated from C. reinhardtii

Ahmad, R.; Bae, A. J.; Su, Y.-J.; Pozveh, S. G.; Bodenschatz, E.; Pumir, A.; Gholami, A.

10.1101/2021.05.19.444861 — biophysics — Posted on 2022-04-05

3317 Assessment of Sex Bias in Housekeeping Gene Expression in Adipose Tissue Through the Massive Analysis of Transcriptomics Data

Guaita-Cespedes, M.; Grillo-Risco, R.; Hidalgo, M. R.; Fernandez-Veledo, S.; Burks, D. J.; de la Iglesia-Vaya, M.; Galan, A.; Garcia-Garcia, F.

10.1101/2021.12.04.471124 — genomics — Posted on 2022-04-05

3318 GPI-anchored FGF directs cytoneme-mediated bidirectional signaling to self-regulate tissue-specific dispersion

Du, L.; Sohr, A.; Li, Y.; Roy, S.

10.1101/2021.02.23.432493 — developmental biology — Posted on 2022-04-05

3319 Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression

Rancourt, A.; Sato, S.; Satoh, M. S.

10.1101/319525 — cell biology — Posted on 2022-04-05

3320 In Utero Activation of NK Cells in Congenital CMV Infection

Vaaben, A. V.; Levan, J.; Nguyen, C. B. T.; Callaway, P. C.; Prahl, M.; Warrier, L.; Nankya, F.; Musinguzi, K.; Kakuru, A.; Muhindo, M. K.; Dorsey, G.; Kamya, M. R.; Feeney, M. E.

10.1101/2022.04.04.487059 — immunology — Posted on 2022-04-05

3321 Bringing the Pig to Comparative Neuroimaging: A Common Space Approach Contextualizes the Pig and Human Structural Connectome

Benn, R. A.; Mars, R. B.; Xu, T.; Yee, J. R.; Rodriguez-Esparragoza, L.; Montesinos, P.; Manzano-Patron, J. P.; Lopez-Martin, G.; Fuster, V.; Sanchez-Gonzalez, J.; Duff, E. P.; Ibanez, B.

10.1101/2020.10.13.337436 — neuroscience — Posted on 2022-04-05

3322 Delayed dynamics of migratory response to CTLA-4 blockade reveals a mechanistic view on potential T cells reinvigoration following immune checkpoint blockade

Safaeifard, F.; Shariatpanahi, S. P.; Golieai, B.; Aref, A. R.; Foroughmand-Araabi, M.-H.; Goliaei, S.; Ruegg, C.

10.1101/2022.04.03.485914 — cancer biology — Posted on 2022-04-05

3323 Efficient Bayesian inference for mechanistic modelling with high-throughput data

Martina Perez, S.; Sailem, H.; Baker, R. E.

10.1101/2022.02.14.480336 — bioinformatics — Posted on 2022-04-05

3324 GoFish: A low-cost, open-source platform for closed-loop behavioural experiments on fish

Ajuwon, V.; Cruz, B. F. P.; Carrico, P.; Champalimaud Foundation Scientific Hardware Platform, ; Kacelnik, A.; Monteiro, T.

10.1101/2022.04.04.486957 — animal behavior and cognition — Posted on 2022-04-05

3325 Species-typical chemical signals mediate reproductive isolation in a teleost fish

Holland, C.; Rosenthal, G. G.

10.1101/2022.04.04.484127 — animal behavior and cognition — Posted on 2022-04-05

3326 A playback paradox? Nathusius' bats, Pipistrellus nathusii, bypass mating and fueling opportunities on migratory transit flights

Marggraf, L. C.; Lindecke, O.; Voigt, C. C.; Petersons, G.; Voigt-Heucke, S. L.

10.1101/2022.04.02.486838 — animal behavior and cognition — Posted on 2022-04-05

3327 Lessons on fruiting body morphogenesis from genomes and transcriptomes of Agaricomycetes

Nagy, L. G.; Vonk, P. J.; Kunzler, M.; Foldi, C.; Viragh, M.; Ohm, R. A.; Hennicke, F.; Balint, B.; Csernetics, A.; Hegedus, B.; Hou, Z.; Liu, X.-b.; Nan, S.; Pareek, M.; Sahu, N.; Szathmari, B.; Varga, T.; Wu, H.; Yang, X.; Merenyi, Z.

10.1101/2021.12.09.471732 — evolutionary biology — Posted on 2022-04-05

3328 Investigating the reliability of molecular estimates of evolutionary time when substitution rates and speciation rates vary

Ritchie, A. M.; Hua, X.; Bromham, L.

10.1101/2021.06.27.450013 — evolutionary biology — Posted on 2022-04-05

3329 Immediate predation risk alters the relationship between potential and realised selection on male traits in the Trinidad guppy Poecilia reticulata

Glavaschi, A.; Cattelan, S.; Devigili, A.; Pilastro, A.

10.1101/2022.04.03.486867 — evolutionary biology — Posted on 2022-04-05

3330 Genome-wide local ancestry and direct evidence for mitonuclear coadaptation in African hybrid cattle populations (Bos taurus/indicus)

Ward, J. A.; McHugo, G. P.; Dover, M. J.; Hall, T. J.; Ng'ang'a, S. I.; Sonstegard, T. S.; Bradley, D. G.; Frantz, L. A.; Salter-Townshend, M.; MacHugh, D. E.

10.1101/2021.08.26.457829 — evolutionary biology — Posted on 2022-04-05

3331 Revealing cell populations catching the early stages of the human embryo development in naive pluripotent stem cells

Moya-Jodar, M.; Ullate-Agote, A.; Barlabe, P.; Rodriguez-Madoz, J. R.; Abizanda, G.; Barreda, C.; Carvajal-Vergara, X.; Vilas-Zornoza, A.; Romero, J. P.; Garate, L.; Agirre, X.; Coppiello, G.; Prosper, F.; Aranguren, X.

10.1101/2022.03.06.482812 — cell biology — Posted on 2022-04-05

3332 Bacterial sirtuin CobB and PRPP synthase crosstalk in regulation of protein acetylation

Walter, B. M.; Morcinek-Orlowska, J.; Szulc, A.; Lovering, A. L.; Banzhaf, M.; Glinkowska, M. K.

10.1101/2020.12.09.417477 — molecular biology — Posted on 2022-04-05

3333 Chromatin reader Dido3 regulates the genetic network of B cell differentiation

Gutierrez del Burgo, F.; Pons, T.; Vazquez de Luis, E.; Martinez-A, C.; Villares, R.

10.1101/2021.02.23.432411 — molecular biology — Posted on 2022-04-05

3334 CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate

Suzuki, T.; Tatsukawa, T.; Sudo, G.; Delandre, C.; Pai, Y. J.; Miyamoto, H.; Raveau, M.; Shimohata, A.; Ohmori, I.; Hamano, S.-i.; Haginoya, K.; Uematsu, M.; Takahashi, Y.; Morimoto, M.; Fujimoto, S.; Osaka, H.; Oguni, H.; Osawa, M.; Ishii, A.; Hirose, S.; Kaneko, S.; Inoue, Y.; Moore, A. W.; Yamakawa, K.

10.1101/2021.09.17.460803 — neuroscience — Posted on 2022-04-05

3335 IDENTIFYING PLANT GENES SHAPING MICROBIOTA COMPOSITION IN THE BARLEY RHIZOSPHERE

Escudero-Martinez, C.; Coulter, M.; Alegria Terrazas, R.; Foito, A.; Kapadia, R.; Pietrangelo, L.; Maver, M.; Sharma, R.; Aprile, A.; Morris, J.; Hedley, P. E.; Maurer, A.; Pillen, K.; Naclerio, G.; Mimmo, T.; Barton, G. J.; Waugh, R.; Abbott, J.; Bulgarelli, D.

10.1101/2021.12.20.472907 — plant biology — Posted on 2022-04-05

3336 BITC induces cardiomyocyte proliferation and heart regeneration

Sakaguchi, A.; Saito, Y.; Kawasaki, M.; Murata, K.; Masumoto, H.; Kimura, W.

10.1101/2021.09.08.459197 — pharmacology and toxicology — Posted on 2022-04-05

3337 Semaphorin 3C exacerbates liver fibrosis

De Angelis Rigotti, F.; Wiedmann, L.; Hubert, M. O.; Vacca, M.; Hasan, S. S.; Moll, I.; Carvajal, S.; Jimenez, W.; Starostecka, M.; Billeter, A. T.; Müller-Stich, B.; Wolff, G.; Ekim-Üstünel, B.; Herzig, S.; Mogler, C.; Fischer, A.; Rodriguez-Vita, J.

10.1101/2021.07.29.454292 — pathology — Posted on 2022-04-05

3338 Comprehensive Structural Variant Detection: From Mosaic to Population-Level

Smolka, M.; Paulin, L. F.; Grochowski, C. M.; Mahmoud, M.; Behera, S.; Gandhi, M.; Hong, K.; Pehlivan, D.; Scholz, S. W.; Carvalho, C. M.; Proukakis, C.; Sedlazeck, F. J.

10.1101/2022.04.04.487055 — bioinformatics — Posted on 2022-04-05

3339 A deep hierarchy of predictions enables assignment of semantic roles in real-time speech comprehension

Su, Y.; Olasagasti, I.; Giraud, A.-L.

10.1101/2022.04.01.486694 — neuroscience — Posted on 2022-04-05

3340 Human statistical learning dynamically shapes the hippocampal processing of temporal associations

Tang, W.; Christiansen, M. H.; Qi, Z.

10.1101/2022.04.04.487009 — neuroscience — Posted on 2022-04-05

3341 Emergence of distinct neural subspaces in motor cortical dynamics during volitional adjustments of ongoing locomotion

Xing, D.; Truccolo, W.; Borton, D. A.

10.1101/2022.04.03.486001 — neuroscience — Posted on 2022-04-05

3342 Genetically encoded sensors for analysing neurotransmission among synaptically-connected neurons

Shindo, Y.; Ashida, K.; Masamoto, K.; Takuwa, H.; Takahashi, M.; Higuchi, M.; Ide, R.; Hotta, K.; Oka, K.

10.1101/2022.04.03.486903 — neuroscience — Posted on 2022-04-05

3343 One-trial social learning of vervet monkey alarm calling

Deshapande, A.; Boekholt, B. v.; Zuberbuhler, K.

10.1101/2022.04.04.486924 — animal behavior and cognition — Posted on 2022-04-05

3344 Socially learned arbitrary call use in a wild primate

Deshapande, A.; Zuberbuhler, K.

10.1101/2022.04.04.486940 — animal behavior and cognition — Posted on 2022-04-05

3345 Chromatin regulates genome-wide transcription factor binding affinities

Neikes, H. K.; Lindeboom, R. G.; Grawe, C.; Lamers, L. A.; Baltissen, M. P.; Jansen, P. W.; van Heeringen, S. J.; Logie, C.; Teichmann, S. A.; Vermeulen, M.

10.1101/2022.04.04.486948 — genomics — Posted on 2022-04-05

3346 Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays

Hirano, T.; Yoshida, M. M.; Kinoshita, K.; Aizawa, Y.; Tane, S.; Yamashita, D.; Shintomi, K.

10.1101/2022.04.04.487030 — cell biology — Posted on 2022-04-05

3347 The angular gyrus is engaged by autobiographical recall not object-semantics, or event-semantics: Evidence from contrastive propositional speech production

Humphreys, G. F.; Halai, A. D.; Branzi, F.; Lambon Ralph, M.

10.1101/2022.04.04.487000 — neuroscience — Posted on 2022-04-05

3348 Transcriptional Heterogeneity and Cell Cycle Regulation as Central Determinants of Primitive Endoderm Priming.

Brickman, J. M.; Perera, M.; Nissen, S. B.; Proks, M.; Pozzi, S.; Monteiro, R. S.; Trusina, A.

10.1101/2022.04.03.486894 — developmental biology — Posted on 2022-04-05

3349 Cholinergic stimulation modulates the functional composition of CA3 cell types in the hippocampus

Puhl, C. J.; Wefelmeyer, W.; Burrone, J.

10.1101/2022.04.04.486716 — neuroscience — Posted on 2022-04-05

3350 Gut Enterochromaffin Cells are Critical Drivers of Visceral Pain and Anxiety

Bayrer, J. R.; Castro, J.; Venkataramen, A.; Touhara, K. K.; Rossen, N. D.; Morrie, R. D.; Hendry, A.; Madden, J.; Braverman, K.; Schober, G.; Brizuela, M.; Bueno Silva, C.; Ingraham, H. A.; Brierley, S. M.; Julius, D.

10.1101/2022.04.04.486775 — physiology — Posted on 2022-04-05

3351 Mutational Changes and Enhanced Cell Migration during Transformation of Breast Non-tumorigenic Cells to Tumorigenic Cells

Lee, S. H. T.; Kim, J. Y.; Kim, P.; Su, C.-Y.; Ahn, E. H.

10.1101/2022.03.27.485986 — cancer biology — Posted on 2022-04-05

3352 Nm-Nano: Predicting 2'-O-methylation (Nm) Sites in Nanopore RNA Sequencing Data

Salem, D. H.; Ariyur, A.; Daulatabad, S. V.; Mir, Q.; Janga, S. C.

10.1101/2022.01.03.473214 — bioinformatics — Posted on 2022-04-05

3353 Forecasting the effects of water regulation on the population viability of a threatened amphibian

Mathwin, R.; Wassens, S.; Gibbs, M.; Young, J.; Ye, Q.; Saltre, F.; Bradshaw, C. J. A.

10.1101/2021.04.20.440713 — ecology — Posted on 2022-04-04

3354 Moxifloxacin-mediated killing of Mycobacterium tuberculosis involves respiratory downshift, reductive stress, and ROS accumulation

Shee, S.; Singh, S.; Tripathi, A.; Thakur, C.; Kumar, A. T.; Das, M.; Yadav, V.; Kohli, S.; Rajmani, R. S.; Chandra, N.; Chakrapani, H.; drlica, K.; Singh, A.

10.1101/2022.04.04.486929 — microbiology — Posted on 2022-04-04

3355 Melanoma cells release DEL-1 via small extracellular vesicles

Schnödl, M.; Tuchmann, F.; Wenzina, J.; Neumüller, k.; Mitulovic, G.; Groeger, M.; Heller, G.; Petzelbauer, P.

10.1101/2022.04.04.487024 — cancer biology — Posted on 2022-04-04

3356 Assessment of AI-based Protein Structure Prediction for the NLRP3 Target

Yin, J.; Yu, J.; Cui, W.; Lei, J.; Chen, W.; Satz, A. L.; Zhou, Y.; Feng, H.; Deng, J.; Su, W.; Kuai, L.

10.1101/2021.11.05.467381 — biochemistry — Posted on 2022-04-04

3357 Surface detection of SARS-CoV-2 by lateral flow LAMP

Acker, I. D.; Ware, M. J.; Bracht, J. R.

10.1101/2022.04.04.487067 — genetics — Posted on 2022-04-04

3358 Molecular differences in APOBEC3 counteraction by primate herpesviruses reveal an evolutionary link between the genesis of APOBEC3B and novel viral ribonucleotide reductase function

Moraes, S. N.; Becker, J.; Moghadasi, S. A.; Shaban, N.; Auerbach, A.; Cheng, A.; Harris, R.

10.1101/2022.04.04.487025 — microbiology — Posted on 2022-04-04

3359 Sub-type selective muscarinic acetylcholine receptor modulation for the treatment of parkinsonian tremor

Bickham, K.; Withers, C. P.; Diedrich, A.; Moehle, M. S.

10.1101/2022.04.04.487007 — neuroscience — Posted on 2022-04-04

3360 Biological responses to terahertz radiation with different power density in primary hippocampal neurons

Zhao, L.; Yi, R.; Liu, S.; Chi, Y.; Tan, S.; Dong, J.; Wang, H.; Zhang, J.; Wang, H.; Xu, X.; Yao, B.; Wang, B.; Peng, R.

10.1101/2022.04.04.487008 — neuroscience — Posted on 2022-04-04

3361 Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

10.1101/2022.04.02.486837 — cancer biology — Posted on 2022-04-04

3362 MAECI: A Pipeline For Generating Consensus Sequence With Nanopore Sequencing Long-read Assembly and Error Correction

Lang, J.

10.1101/2022.04.04.487014 — bioinformatics — Posted on 2022-04-04

3363 Lumbar time-varying muscle synergies in trunk flexion and bending movements at different velocities

Bagheri, M.; Davoudi, M.; Meftahi, N.; Parnianpour, M.; Khalaf, K.; Rashedi, E.

10.1101/2022.04.04.487027 — bioengineering — Posted on 2022-04-04

3364 Screening candidate genes related to psoas muscle traits in Debao and Landrace pigs based on transcriptome analysis

Chen, C.-y.; Zeng, S.-x.; Ma, Y.-d.; Zheng, J.-w.; Li, X.; Xiong, C.-y.; Zhou, H.-j.; Wei, C.-t.; li, Z.

10.1101/2022.04.04.487004 — genomics — Posted on 2022-04-04

3365 Ultrastructure Expansion Microscopy (U-ExM) in Trypanosoma cruzi: localization of tubulin isoforms and isotypes

Alonso, V. L.

10.1101/2022.03.06.483067 — cell biology — Posted on 2022-04-04

3366 Engineering functional membrane-membrane interface by InterSpy

Moghimianavval, H.; Patel, C.; Mohapatra, S.; Hwang, S.-W.; Kayikcioglu, T.; Bashirzadeh, Y.; Liu, A. P.; Ha, T.

10.1101/2022.04.04.487023 — synthetic biology — Posted on 2022-04-04

3367 Structural and Preliminary Biochemical Characterization of MppQ, a PLP-Dependent Aminotransferase from Streptomyces hygroscopicus

Vuksanovic, N.; Serrano, D. A.; Schwabacher, A. W.; Silvaggi, N. R.

10.1101/2022.04.03.486910 — biochemistry — Posted on 2022-04-04

3368 Nuclease proteins CifA and CifB promote spermatid DNA damage associated with symbiont-induced cytoplasmic incompatibility

Kaur, R.; Shropshire, J. D.; Leigh, B. A.; Bordenstein, S. R.

10.1101/2022.04.04.487029 — biochemistry — Posted on 2022-04-04

3369 Mechanism-based crosslinking probes capture E. coli ketosynthase FabB in conformationally-distinct catalytic states.

Chen, A.; Mindrebo, J. T.; Davis, T. D.; Kim, W. E.; Katsuyama, Y.; Jiang, Z.; Ohnishi, Y.; Noel, J. P.; Burkart, M. D.

10.1101/2022.04.04.486996 — biochemistry — Posted on 2022-04-04

3370 Comparing evolvability and pleiotropy across environments

Tarkington, J. A.; Zufall, R.

10.1101/2022.04.01.485835 — evolutionary biology — Posted on 2022-04-04

3371 Genomic legacies of ancient adaptation illuminate the GC-content evolution in bacterial genomes

Teng, W.; Liao, B.; Chen, M.; Shu, W.

10.1101/2022.04.02.486805 — evolutionary biology — Posted on 2022-04-04

3372 hemispheR: an R package for fisheye canopy image analysis

Chianucci, F.; Macek, M.

10.1101/2022.04.01.486683 — ecology — Posted on 2022-04-04

3373 Western spotted skunks provide important food web linkages in forest of the Pacific Northwest

Tosa, M. I.; Lesmeister, D. B.; Levi, T.

10.1101/2022.04.01.486736 — ecology — Posted on 2022-04-04

3374 Rheology of growing axons

Oliveri, H.; de Rooij, R.; Kuhl, E.; Goriely, A.

10.1101/2022.04.01.485819 — developmental biology — Posted on 2022-04-04

3375 Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.

Hall, E. A.; Kumar, D.; Prosser, S. L.; Yeyati, P. L.; Herranz-Pérez, V.; Garcia Verdugo, J. M.; Rose, L.; McKie, L.; Dodd, D. O.; Tennant, P. A.; Megaw, R.; Murphy, L. C.; Ferreira, M.; Grimes, G.; Williams, L.; Pelletier, L.; Quidwai, T.; Reiter, J. F.; Mill, P.

10.1101/2022.04.04.486992 — cell biology — Posted on 2022-04-04

3376 Overactive mitochondrial DNA replisome causes neonatal heart failure via ferroptosis

Landoni, J. C.; Laalo, T.; Goffart, S.; Kivelä, R.; Skube, K.; Nieminen, A. I.; Wickström, S. A.; Stewart, J.; Suomalainen, A.

10.1101/2022.04.04.485133 — molecular biology — Posted on 2022-04-04

3377 Nrf2 prevents diabetic cardiomyopathy via antioxidation and normalization of glucose and lipid metabolism in the heart

Yang, G.; Zhang, Q.; Dong, C.; Hou, G.; Li, J.; Meng, L.; Jiang, X.; Xin, Y.

10.1101/2022.04.04.486954 — molecular biology — Posted on 2022-04-04

3378 Re-engineering of CUP1 promoter and Cup2/Ace1 transactivator to convert Saccharomyces cerevisiae into a whole-cell eukaryotic biosensor capable of detecting 10 nM of bioavailable copper

Zunar, B.; Mosrin, C.; Benedetti, H.; Vallee, B.

10.1101/2022.04.04.486947 — molecular biology — Posted on 2022-04-04

3379 Evidence for a widespread third system for bacterial polysaccharide export across the outer membrane comprising a composite OPX/β-barrel translocon

Schwabe, J.; Perez-Burgos, M.; Herfurth, M.; Glatter, T.; Sogaard-Andersen, L.

10.1101/2022.04.04.486985 — microbiology — Posted on 2022-04-04

3380 Anthropogenic disturbance impacts gut microbiome homeostasis in a Malagasy primate

Wasimuddin, ; Malik, H.; Ratovonamana, Y. R.; Rakotondranary, S. J.; Ganzhorn, J. U.; Sommer, S.

10.1101/2022.04.02.486803 — microbiology — Posted on 2022-04-04

3381 Moxifloxacin-mediated killing of Mycobacterium tuberculosis involves respiratory downshift, reductive stress, and ROS accumulation

Shee, S.; Singh, S.; Tripathi, A.; Thakur, C.; Kumar, A. T.; Das, M.; Yadav, V.; Kohli, S.; Rajmani, R. S.; Chandra, N.; Chakrapani, H.; drlica, K.; Singh, A.

10.1101/2022.04.04.486929 — microbiology — Posted on 2022-04-04

3382 Retraction ATPase motors from three orthologous type IVa pilus systems support promiscuous retraction of the Vibrio cholerae competence pilus

Couser, E.; Chlebek, J. L.; Dalia, A. B.

10.1101/2021.10.23.465551 — microbiology — Posted on 2022-04-04

3383 Modulation of the gut microbiome by novel synthetic glycans for the production of propionate and the reduction of cardiometabolic risk factors

Millet, Y. A.; Meisner, J.; Tan, J.; Jose, A.; Humphries, E.; Miller, K. J.; Bayne, C.; McComb, M.; Giuggio, M.; Konopnicki, C. M.; Belanger, D. B.; Li, L.; Yuan, H.; Rosini, M.; Luong, H.; Martin, J.; Pan, Z.; Kahn, C. R.; van Hylckama Vlieg, J. E.

10.1101/2022.04.04.487010 — microbiology — Posted on 2022-04-04

3384 Identification and functional characterization of two heme uptake systems required for virulence of the fish pathogen Flavobacterium psychrophilum

Zhu, Y.; Lechardeur, D.; Bernardet, J.-F.; Kerouault, B.; Guerin, C.; Rigaudeau, D.; Nicolas, P.; Duchaud, E.; Rochat, T.

10.1101/2022.04.04.486927 — microbiology — Posted on 2022-04-04

3385 CCR4 and CCR7 differentially regulate thymocyte subset localization with distinct outcomes for central tolerance

Li, Y.; Srinivasan, J.; Selden, H. J.; Ehrlich, L. I. R.

10.1101/2022.04.03.486911 — immunology — Posted on 2022-04-04

3386 Older circuits get richer: neurogenesis timeline shapes hubness and neurogenetic profiles of the adult human brain

diez, I.; Moreno, F. G.; Sainz, N. C.; Stramaglia, S.; Reyes, A. N.; D'Amato, M.; Cortes, J. M.; bonifazi, p.

10.1101/2022.04.01.486541 — neuroscience — Posted on 2022-04-04

3387 Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome

Hoffmann, N.; Rahman, S.; Worden, E. J.; Smith, M. L.; Namitz, K. E.; Knutson, B.; Cosgrove, M. S.; Wolberger, C.

10.1101/2022.04.04.486905 — biophysics — Posted on 2022-04-04

3388 Structure Determination of Inactive-State GPCRs with a Universal Nanobody

Robertson, M. J.; Papasergi-Scott, M. M.; He, F.; Seven, A. B.; Meyerowitz, J. G.; Panova, O.; Peroto, M.-C.; Che, T.; Skiniotis, G.

10.1101/2021.11.02.466983 — biophysics — Posted on 2022-04-04

3389 Unbreakable DNA tension probes show that cell adhesion receptors detect the molecular force-extension curve of their ligands

Bender, R. L.; Ogasawara, H.; Kellner, A. V.; Velusamy, A.; Salaita, K.

10.1101/2022.04.04.487040 — biophysics — Posted on 2022-04-04

3390 Deep Learning Achieves Neuroradiologist-Level Performance in Detecting Hydrocephalus Requiring Treatment

Huang, Y.; Moreno, R.; Malani, R.; Meng, A.; Swinburne, N.; Holodny, A. I.; Choi, Y.; Rusinek, H.; Golomb, J. B.; George, A.; Parra, L. C.; Young, R. J.

10.1101/2021.01.19.427328 — bioinformatics — Posted on 2022-04-04

3391 The Modular μSiM Reconfigured: Integration of Microfluidic Capabilities to Study in vitro Barrier Tissue Models under Flow

Mansouri, M.; Ahmed, A.; Ahamd, D.; McCloskey, M. C.; Joshi, I. M.; Gaborski, T. R.; Waugh, R. E.; McGrath, J. L.; Day, S. W.; Abhyankar, V. V.

10.1101/2022.03.28.486107 — bioengineering — Posted on 2022-04-04

3392 Structure and function of a Notch-like proteolytic switch domain in the extracellular matrix receptor dystroglycan

Anderson, M. J.; Hayward, A. N.; Grant, E.; Greenberg, L.; Evans, R. L.; Gordon, W. R.

10.1101/2022.04.04.487063 — biochemistry — Posted on 2022-04-04

3393 Two pathways drive meiotic chromosome axis assembly in Saccharomyces cerevisiae

Heldrich, J.; Milano, C. R.; Markowitz, T. E.; Ur, S. N.; Vale-Silva, L. A.; Corbett, K. D.; Hochwagen, A.

10.1101/2020.08.11.247122 — genomics — Posted on 2022-04-04

3394 Transmembrane helices 5 and 12 control transport dynamics, substrate affinity and specificity in the elevator-type UapA transporter

Dimakis, D.; Pyrris, Y.; Diallinas, G.

10.1101/2022.04.04.486963 — genetics — Posted on 2022-04-04

3395 Neuroendocrine control of the proteostatic network by HPK-1 delays aging

Lazaro-Pena, M.; Diaz-Balzac, C. A.; Das, R.; Samuelson, A. V.

10.1101/2022.04.02.486836 — genetics — Posted on 2022-04-04

3396 Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing mice

Natekar, J. P.; Pathak, H.; Stone, S.; Kumari, P.; Sharma, S.; Arora, K.; Rothan, H. A.; Kumar, M.

10.1101/2022.04.04.486975 — microbiology — Posted on 2022-04-04

3397 Unique genomic sequences in novel Mycobacterium avium subsp. hominissuis lineage enabled fine scale tracing the transmission route during pig movement

Komatsu, T.; Ohya, K.; Ota, A.; Nishiuchi, Y.; Yano, H.; Matsuo, K.; Odoi, J. O.; Suganuma, S.; Sawai, K.; Hasebe, A.; Asai, T.; Yanai, T.; Fukushi, H.; Wada, T.; Yoshida, S.; Arikawa, K.; Ito, T.; Kawai, M.; Ato, M.; Baughn, A. D.; Iwamoto, T.; MARUYAMA, F.

10.1101/2022.04.04.487006 — microbiology — Posted on 2022-04-04

3398 Intracellular acidification is a hallmark of thymineless death in E. coli

Ketcham, A.; Freddolino, P.; Tavazoie, S.

10.1101/2022.04.04.487045 — microbiology — Posted on 2022-04-04

3399 Toxoplasma gondii Coq1 is a heptaprenyl diphosphate synthase and its inhibition by a lipophilic bisphosphonate protects mice against T. gondii infection

Sleda, M. A.; Li, Z.-H.; Behera, R.; Baierna, B.; Li, C.; Junpathong, J.; Malwal, S. R.; Kawamukai, M.; Oldfield, E.; Moreno, S. N. J.

10.1101/2022.04.04.487054 — microbiology — Posted on 2022-04-04

3400 Epithelial and neutrophil interactions and coordinated response to Shigella in a human intestinal enteroid-neutrophil co-culture model

Lemme-Dumit, J. M.; Doucet, M.; Zachos, N.; Pasetti, M. F.

10.1101/2020.09.03.281535 — immunology — Posted on 2022-04-04

3401 Distinguishing shadows from surface boundaries using local achromatic cues

DiMattina, C.; Burnham, J. J.; Guner, B. N.; Yerxa, H. B.

10.1101/2022.03.08.483480 — neuroscience — Posted on 2022-04-04

3402 Control of bacterial immune signaling by a WYL domain transcription factor

Blankenchip, C. L.; Nguyen, J. V.; Lau, R. K.; Ye, Q.; Gu, Y.; Corbett, K. D.

10.1101/2022.01.04.474952 — biophysics — Posted on 2022-04-04

3403 Contrastive Cycle Adversarial Autoencoders for Single-cell Multi-omics Alignment and Integration

Wang, X.; Hu, Z.; Yu, T.; Wang, Y.; Wang, R.; Wei, Y.; Shu, J.; Ma, J.; Li, Y.

10.1101/2021.12.12.472268 — bioinformatics — Posted on 2022-04-04

3404 Sparse and Skew Hashing of K-Mers

Pibiri, G. E.

10.1101/2022.01.15.476199 — bioinformatics — Posted on 2022-04-04

3405 De novo human brain enhancers created by single nucleotide mutations

Li, S.; Hannenhalli, S.; Ovcharenko, I.

10.1101/2021.07.04.451055 — genomics — Posted on 2022-04-04

3406 Ctenophore extracellular DNA traps demonstrate conserved antimicrobial behaviors presentat the emergence of animals

Vandepas, L. E.; Stefani, C.; Traylor-Knowles, N.; Goetz, F. W.; Browne, W. E.; Lacy-Hulbert, A.

10.1101/2020.06.09.141010 — evolutionary biology — Posted on 2022-04-04

3407 Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress

Cho, U. H.; Hetzer, M. W.

10.1101/2021.08.31.458302 — cell biology — Posted on 2022-04-04

3408 Moonlighting proteins activate transformation in epigenetically-differentiated phase variants of multidrug-resistant Streptococcus pneumoniae

Kwun, M. J.; Ion, A. V.; Oggioni, M. R.; Bentley, S. D.; Croucher, N. J.

10.1101/2022.03.07.483185 — microbiology — Posted on 2022-04-04

3409 Changes in m6A RNA methylation of goat lung following PPRV infection

Khan, R. I. N.; Praharaj, M. R.; Malla, W. A.; Hosamani, N.; Saxena, S.; Mishra, B.; Rajak, K. K.; Dhanavelu, M.; Tiwari, A. K.; Mishra, B. P.; Sajjanar, B.; Gandham, R. K.

10.1101/2022.03.24.485342 — microbiology — Posted on 2022-04-04

3410 Emotional states as distinct configurations of functional brain networks

Dan, R.; Weinstock, M.; Goelman, G.

10.1101/2021.07.23.453552 — neuroscience — Posted on 2022-04-04

3411 Whole-brain comparison of rodent and human brains using spatial transcriptomics

Beauchamp, A.; Yee, Y.; Darwin, B.; Raznahan, A.; Mars, R. B.; Lerch, J. P.

10.1101/2022.03.18.484766 — neuroscience — Posted on 2022-04-04

3412 Effective and Efficient Neural Networks for Spike Inference from In Vivo Calcium Imaging

Zhou, Z.; Yip, H. M.; Tsimring, K.; Sur, M.; Ip, J. P. K.; Tin, C.

10.1101/2021.08.30.458217 — neuroscience — Posted on 2022-04-04

3413 Spatio-temporal modeling reveals a layer of tunable control circuits for the distribution of cytokines in tissues

Brunner, P.; Kiwitz, L.; Thurley, K.

10.1101/2022.03.17.484722 — systems biology — Posted on 2022-04-04

3414 Concealed identity information detection with pupillometry in rapid serial visual presentation

Chen, I. Y.; Karabay, A.; Mathot, S.; Bowman, H.; Akyurek, E.

10.1101/2021.06.18.448944 — physiology — Posted on 2022-04-04

3415 m6A reader Pho92 is recruited co-transcriptionally and couples translation efficacy to mRNA decay to promote meiotic fitness in yeast

Varier, R. A.; Sideri, T.; Capitanchik, C.; Manova, Z.; Calvani, E.; Rossi, A.; Edupuganti, R.; Ensinck, I.; Chan, V. W. C.; Patel, H.; Kirkpatrick, J.; Faull, P.; Snijders, A. P.; Vermeulen, M.; Ralser, M.; Ule, J.; Luscombe, N. M.; van Werven, F.

10.1101/2022.01.20.477035 — biochemistry — Posted on 2022-04-04

3416 A scalable phenotyping approach for female floral organ development and senescence in the absence of pollination in wheat

Millan-Blanquez, M.; Hartley, M.; Bird, N.; Manes, Y.; Uauy, C.; Boden, S.

10.1101/2022.04.01.486528 — plant biology — Posted on 2022-04-04

3417 Cellular dynamics of endosperm development in Arabidopsis thaliana

Ali, M. F.; Shin, J.-M.; Fatema, U.; Kurihara, D.; Berger, F.; Yuan, L.; Kawashima, T.

10.1101/2022.04.01.485647 — plant biology — Posted on 2022-04-04

3418 Combined drought resistance strategies and the hydraulic limit in co-existing Mediterranean woody species

Alon, A.; Cohen, S.; Burlett, R.; Hochberg, U.; Lukyanov, V.; Rog, I.; Klein, T.; Cochard, H.; Delzon, S.; David-Schwartz, R.

10.1101/2022.04.01.486704 — plant biology — Posted on 2022-04-04

3419 Genomic regions associate with major axes of variation in gas exchange and leaf construction traits in cultivated sunflower (Helianthus annuus L.)

Earley, A. M.; Temme, A. A.; Cotter, C. R.; Burke, J. M.

10.1101/2022.04.01.486477 — plant biology — Posted on 2022-04-04

3420 Genomic insights into present local adaptation and future climate change vulnerability of a keystone forest tree species in East Asian

Sang, Y.; Long, Z.; Dan, X.; Feng, J.; Shi, T.; Jia, C.; Zhang, X.; Lai, Q.; Yang, G.; Zhang, H.; Xu, X.; Liu, H.; Jiang, Y.; Ingvarsson, P. K.; Liu, J.; Mao, K.; Wang, J.

10.1101/2022.04.04.486908 — evolutionary biology — Posted on 2022-04-04

3421 How development affects evolution

Gonzalez-Forero, M.; Gardner, A.

10.1101/2021.10.20.464947 — evolutionary biology — Posted on 2022-04-04

3422 Evolutionary relations between mycorrhizal symbiosis and plant-plant communication in trees

Yamawo, A.; Tomika, H.; Yoshida, S.; Misuzu, O.; Nakajima, R.; Mori, Y.; Hayashi, T.; Yamagishi, H.; Shiojiri, K.

10.1101/2022.04.04.486918 — ecology — Posted on 2022-04-04

3423 Anatomy and Symbiosis of the digestive system of the vent shrimps Rimicaris exoculata and Rimicaris chacei revealed through imaging approaches.

Gueganton, M.; Rouxel, O.; Durand, L.; Cueff-Gauchard, V.; Gayet, N.; Pradillon, F.; Cambon-Bonavita, M.-A.

10.1101/2022.04.04.486049 — microbiology — Posted on 2022-04-04

3424 Emergence and clonal expansion in Europe of Vibrio aestuarianus lineages pathogenic for oysters

Mesnil, A.; Jacquot, M.; Garcia, C.; Tourbiez, D.; Canier, L.; Bidois, A.; Degremont, L.; Cheslett, D.; Geary, M.; Vetri, A.; Roque, A.; Furones, D.; Garden, A.; Orozova, P.; Arzul, I.; Sicard, M.; Charriere, G.; Destoumieux-Garzon, D.; Travers, M.-A.

10.1101/2022.04.04.486953 — microbiology — Posted on 2022-04-04

3425 Accumulated 3-phosphoglycerate in darkness is a primary starting substrate for stepwise photosynthetic induction process in cyanobacteria

Tanaka, K.; Shirai, T.; Matsuda, M.; Kondo, A.; Hasunuma, T.

10.1101/2022.04.04.486922 — plant biology — Posted on 2022-04-04

3426 Screening of candidate host cell membrane proteins involved in SARS-CoV-2 entry

Kotani, N.; Nakano, T.; Kuwahara, R.

10.1101/2020.09.09.289488 — biochemistry — Posted on 2022-04-04

3427 Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design

Weilguny, L.; De Maio, N.; Munro, R.; Manser, C.; Birney, E.; Loose, M.; Goldman, N.

10.1101/2020.02.07.938670 — genomics — Posted on 2022-04-04

3428 Local fitness and epistatic effects lead to distinct patterns of linkagedisequilibrium in protein-coding genes

Ragsdale, A. P.

10.1101/2021.03.25.437004 — evolutionary biology — Posted on 2022-04-04

3429 Dissociation of β2m from MHC Class I Triggers Formation of Noncovalent, Transient Heavy Chain Dimers

Dirscherl, C.; Loechte, S.; Hein, Z.; Kopicki, J.-D.; Harders, A. R.; Linden, N.; Karner, a.; preiner, j.; Weghuber, J.; Garcia-Alai, M.; Uetrecht, C.; Zacharias, M.; Piehler, J.; Lanzerstorfer, P.; Springer, S.

10.1101/2021.07.02.450866 — cell biology — Posted on 2022-04-04

3430 In Vitro Activity of Cysteamine Against SARS-CoV-2 Variants

Thoene, J. G.; Gavin, R. F.; Towne, A.; Wattay, L.; Ferrari, M. G.; Pal, R.

10.1101/2021.10.02.462862 — microbiology — Posted on 2022-04-04

3431 Brequinar and Dipyridamole in Combination Exhibits Synergistic Antiviral Activity Against SARS-CoV-2 in vitro: Rationale for a host-acting antiviral treatment strategy for COVID-19

Demarest, J. F.; Kienle, M.; Boytz, R.; Ayres, M.; Kim, E.; Chung, D.; Gandhi, V.; Davey, R. A.; Sykes, D. B.; Shohdy, N.; Pottage, J. C.; Kumar, V. S.

10.1101/2022.03.30.486499 — microbiology — Posted on 2022-04-04

3432 Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variants

Wang, E.; Chakraborty, A. K.

10.1101/2022.01.24.477469 — immunology — Posted on 2022-04-04

3433 Quantifying the impact of ecological memory on the dynamics of interacting communities

Khalighi, M.; Sommeria-Klein, G.; Gonze, D.; Faust, K.; Lahti, L.

10.1101/2021.09.01.458486 — systems biology — Posted on 2022-04-04

3434 Genomic Surveillance of COVID-19 Variants with Language Models and Machine Learning

Nagpal, S.; Pal, R.; Ashima, ; Tyagi, A.; Tripathi, S.; Nagori, A.; Ahmad, S.; Mishra, H. P.; Kutum, R.; Sethi, T.

10.1101/2021.05.25.445601 — bioinformatics — Posted on 2022-04-04

3435 Rare and population-specific functional variation across pig lines

Ros-Freixedes, R.; Valente, B. D.; Chen, C.-Y.; Herring, W. O.; Gorjanc, G.; Hickey, J. M.; Johnsson, M.

10.1101/2022.02.01.478603 — genomics — Posted on 2022-04-04

3436 Late-acting self-incompatible system, preferential allogamy and delayed selfing in the heteromorphic invasive populations of Ludwigia grandiflora subsp. hexapetala

Portillo Lemus, L. O.; Harang, M.; Bozec, M.; Haury, J.; Stoeckel, S.; Barloy, D.

10.1101/2021.07.15.452457 — ecology — Posted on 2022-04-04

3437 Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

Ranti, D.; Wang, Y.-S.; Daza, J.; Bieber, C.; Salome, B.; Merritt, E.; Cavallo, J.-A.; Hegewisch-Solloa, E.; Mace, E. M.; Farkas, A. M.; Schroff, S.; Lee, B.; Tran, M.; Strandgaard, T.; Lindskrog, S. V.; Dyrskjot, L.; Qi, J.; Patel, M.; Geanon, D.; Kelly, G.; Dereal, R.; Lee, B.; Kim-Schulze, S.; Thin, T. H.; Garcia-Barros, M.; Beaumont, K. G.; Lee, Y.; LaRoche, D.; Sebra, R.; Brody, R.; Tocheva, A.; Hopkins, B.; Wiklund, P.; Galsky, M. D.; Bhardwaj, N.; Sfakianos, J. P.; Horowitz, A.

10.1101/2022.03.06.483198 — immunology — Posted on 2022-04-04

3438 One-sided design of protein-protein interaction motifs using deep learning

Syrlybaeva, R.; Strauch, E.-M.

10.1101/2022.03.30.486144 — bioinformatics — Posted on 2022-04-04

3439 Phylogenomics Illuminates the Evolutionary History of Wild Silkmoths in Space and Time (Lepidoptera: Saturniidae)

Rougerie, R.; Cruaud, A.; Arnal, P.; Ballesteros-Mejia, L.; Condamine, F. L.; Decaens, T.; Elias, M.; Gey, D.; Hebert, P. D. N.; Kitching, I. J.; Lavergne, S.; Lopez-Vaamonde, C.; Murienne, J.; Cuenot, Y.; Nidelet, S.; Rasplus, J.-Y.

10.1101/2022.03.29.486224 — evolutionary biology — Posted on 2022-04-04

3440 Large-scale analysis and computer modeling reveal hidden regularities behind variability of cell division patterns in Arabidopsis thaliana embryogenesis

Laruelle, E.; Belcram, K.; Trubuil, A.; Palauqui, J.-C.; Andrey, P.

10.1101/2022.03.23.483962 — developmental biology — Posted on 2022-04-04

3441 Transcriptional dynamics of colorectal cancer risk associated variation at 11q23.1 are correlated with tuft cell abundance and marker expression in silico

Harris, B. T.; Rajasekaran, V.; Blackmur, J. P.; O'Callaghan, A.; Donnelly, K.; Timofeeva, M.; Vaughan-Shaw, P.; Din, F. V. N.; Dunlop, M. G.; Farrington, S. M.

10.1101/2022.03.29.485182 — bioinformatics — Posted on 2022-04-04

3442 A personalizable autonomous neural mass model of epileptic seizures

Lopez-Sola, E.; Sanchez-Todo, R.; Lleal, E.; Köksal-Ersöz, E.; Yochum, M.; Makhalova, J.; Mercadal, B.; Salvador, R.; Lozano-Soldevilla, D.; Modolo, J.; Bartolomei, F.; Wendling, F.; Benquet, P.; Ruffini, G.

10.1101/2021.12.24.474090 — neuroscience — Posted on 2022-04-04

3443 Multiomic analisys reveals that viroid infection induces a temporal reprograming of plant-defence mechanisms at multiple regulatory levels

Marquez-Molins, J.; Villalba-Bermell, P.; Corell-Sierra, J.; Pallas, V.; Gomez, G.

10.1101/2022.01.06.475203 — plant biology — Posted on 2022-04-04

3444 Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

Dening, Y. F.; Strassl, T.; Ruf, V.; Dirscherl, P.; Chovsepian, A.; Stievenard, A.; Khairnar, A. S.; Schmidt, F.; Giesert, F.; Herms, J.; Levin, J.; Dieterich, M.; Falkai, P.; Vogt, D. M.; Wurst, W.; Giese, A.; Pan-Montojo, F. J.

10.1101/2022.03.31.486401 — neuroscience — Posted on 2022-04-04

3445 Tegaserod maleate suppresses the growth of gastric cancer in vivo and in vitro by targeting MEK1/2

Liu, K.; jiang, y.; wang, z.; chen, y.

10.1101/2022.04.01.486698 — pathology — Posted on 2022-04-04

3446 distinct: a novel approach to differential distribution analyses

Tiberi, S.; Crowell, H. L.; Samartsidis, P.; Weber, L. M.; Robinson, M. D.

10.1101/2020.11.24.394213 — bioinformatics — Posted on 2022-04-04

3447 A single-cell clusters similarity measure for different batches, datasets, and samples

Gonzalez-Velasco, O.; Sanchez-Luis, E.; De La Rosa, E.; Sanchez-Santos, J. M.; De Las Rivas, J.

10.1101/2022.03.14.483731 — bioinformatics — Posted on 2022-04-04

3448 Antibodies to Coagulase of Staphylococcus aureus crossreact to Efb and reveal different binding of shared Fibrinogen Binding repeats

Bertoglio, F.; Ko, Y.-P.; Thomas, S.; Giordano, L.; Scommegna, F. R.; Meier, D.; Polten, S.; Becker, M.; Arora, S.; Hust, M.; Höök, M.; Visai, L.

10.1101/2022.04.01.486801 — biochemistry — Posted on 2022-04-04

3449 Dominance vs. epistasis: the biophysical origins and plasticity of genetic interactions within and between alleles

Xie, X.; Lehner, B.; Li, X.

10.1101/2022.04.03.486855 — genetics — Posted on 2022-04-04

3450 Allele mining, evolutionary genetic analysis of TaHKT1;5 gene and evaluation of salinity stress in selected lines of wheat.

Thiyagarajan, K.; Mathur, P. N.; Vikram, P.; Sehgal, D.; Valluru, R.; Govindan, V.; Rahman, H.; Thapa, D. B.; Pantha, S.; Galeffi, P.; Latini, A.; Cantale, C.; Porceddu, E.; Joshi, A. K.

10.1101/2022.04.01.486792 — genetics — Posted on 2022-04-04

3451 The interplay between habitat fragmentation and life traits affects specialization in lichen symbioses

Berlinches de Gea, A.; Verdu, M.; Villar-dePablo, M.; Perez-Ortega, S.

10.1101/2022.03.30.485788 — ecology — Posted on 2022-04-04

3452 Growth rate controls the sensitivity of gene regulatory circuits

Julou, T.; Gervais, T.; Blank, D.; van Nimwegen, E.

10.1101/2022.04.03.486858 — systems biology — Posted on 2022-04-04

3453 A brain-inspired object-based attention network for multi-object recognition and visual reasoning

Adeli, H.; Ahn, S.; Zelinsky, G.

10.1101/2022.04.02.486850 — animal behavior and cognition — Posted on 2022-04-04

3454 Integrative analysis of metabolite GWAS illuminates the molecular basis of pleiotropy and genetic correlation

Smith, C. J.; Sinnott-Armstrong, N.; Cichonska, A.; Julkunen, H.; Fauman, E.; Wurtz, P.; Pritchard, J. K.

10.1101/2022.04.02.486791 — genomics — Posted on 2022-04-04

3455 Perturbed actin cap and nuclear morphology in primary fibroblasts of Huntington's disease patients as a new phenotypic marker for personalized drug evaluation

Gharaba, S.; Paz, O.; Feld, L.; Abashidze, A.; Weinrab, M.; Wolfenson, H.; Weil, M.

10.1101/2022.04.03.486386 — cell biology — Posted on 2022-04-04

3456 Vimentin Intermediate Filaments Can Enhance or Abate Active Cellular Forces in a Microenvironmental Stiffness-Dependent Manner

Alisafaei, F.; Mandal, K.; Swoger, M.; Yang, H.; Guo, M.; Janmey, P.; Patteson, A. E.; Shenoy, V.

10.1101/2022.04.02.486829 — biophysics — Posted on 2022-04-04

3457 A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator

Doherty, T.; Dempster, E.; Hannon, E.; Mill, J.; Poulton, R.; Corcoran, D.; Sugden, K.; Williams, B.; Caspi, A.; Moffitt, T. E.; Delany, S. J.; Murphy, T. M.

10.1101/2022.04.02.486242 — bioinformatics — Posted on 2022-04-03

3458 Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Rebsamen, M.; Girardi, E.; Sedlyarov, V.; Papakostas, K.; Konecka, J.; Vollert, M.; Scorzoni, S.; Guertl, B.; Klavins, K.; Wiedmer, T.; Superti-Furga, G.

10.1101/2022.04.03.486870 — cell biology — Posted on 2022-04-04

3459 Active emulsions in living cell membranes driven by contractile stresses and transbilayer coupling

Saha, S.; Das, A.; Patra, C.; Anilkumar, A. A.; Sil, P.; Mayor, S.; Rao, M.

10.1101/2022.04.02.486649 — cell biology — Posted on 2022-04-04

3460 Simultaneous adjustments of major mitochondrial pathways through redox regulation of dihydrolipoamide dehydrogenase (mtLPD1)

Timm, S.; Klaas, N.; Niemann, J.; Jahnke, K.; Alseekh, S.; Zhang, Y.; Souza, P.; Hou, L.-Y.; Geigenberger, P.; Daloso, D. M.; Fernie, A. R.; Hagemann, M.

10.1101/2022.04.02.486831 — plant biology — Posted on 2022-04-03

3461 Establishing combination PAC-1 and TRAIL regimens for treating ovarian cancer based on patient-specific pharmacokinetic profiles using in silico clinical trials

Cardinal, O.; Burlot, C.; Fu, Y.; Crosley, P.; Hitt, M.; Craig, M.; Jenner, A. L.

10.1101/2022.03.29.486309 — cancer biology — Posted on 2022-04-03

3462 Scanning Single Molecule Localization Microscopy (scanSMLM) for super-resolution optical volume imaging

Basumatary, J.; Baro, N.; Joshi, P.; Mondal, P. P.

10.1101/2022.04.01.486682 — biophysics — Posted on 2022-04-03

3463 Thermal Effects on Neurons During Stimulation of the Brain

Kim, T.; Kadji, H.; Whalen, A.; Ashourvan, A.; Freeman, E.; Fried, S.; Tadigadapa, S.; Schiff, S. J.

10.1101/2022.04.02.486840 — biophysics — Posted on 2022-04-03

3464 A Miniaturized 3D-Printed Pressure Regulator (μPR) for Microfluidic Cell Culture Applications

Hsu, M.-C.; Mansouri, M.; Ahamed, N. N. N.; Joshi, I. M.; Ahmed, A.; Borkholder, D. A.; Abhyankar, V. V.

10.1101/2022.04.03.486540 — bioengineering — Posted on 2022-04-03

3465 Nonlethal effects of predation: Presence of insectivorous birds affects the behaviour and level of stress in insects

Kollross, J.; Jancuchova-Laskova, J.; Kleckova, I.; Sam, K.; Kodrik, D.; Freiberga, I.

10.1101/2022.04.01.486535 — animal behavior and cognition — Posted on 2022-04-03

3466 Rapid loss of fine motor skills after low dose space radiation exposure

Blackwell, A. A.; Fesshaye, A.; Tidmore, A.; Wallace, D. G.; Britten, R. A.

10.1101/2022.04.01.486651 — animal behavior and cognition — Posted on 2022-04-03

3467 Fungal States of Minds

Adamatzky, A.; Valverdu, J.; Gandia, A.; Chiolerio, A.; Castro, O.; Dodig-Crnkovic, G.

10.1101/2022.04.03.486900 — animal behavior and cognition — Posted on 2022-04-03

3468 Population estimation of a cryptic moss frog using acoustic spatially explicit capture recapture

Stark, D.; Turner, A. A.; van Rensburg, B. J.; Measey, J.

10.1101/2022.04.01.486679 — ecology — Posted on 2022-04-03

3469 Saving the Devils is in the details: Tasmanian Devil facial tumor disease can be eliminated with interventions

Drawert, B.; Matthew, S.; Powell, M.; Rumsey, B.

10.1101/2022.04.03.486872 — ecology — Posted on 2022-04-03

3470 Unravelling specific diet and gut microbial contributions to inflammatory bowel disease

Vasconcelos Pereira, G.; Boudaud, M.; Wolter, M.; Alexander, C.; De Sciscio, A.; Grant, E.; Caetano Trindade, B.; Singh, S.; Campbell, A.; Pudlo, N.; Willieme, S.; Craig, S.; Kim, K.; Denike-Duval, T.; Kennedy, L.; Schmidt, T.; Chen, G.; Eaton, K.; Desai, M. S.; Martens, E. C.

10.1101/2022.04.03.486886 — microbiology — Posted on 2022-04-03

3471 Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala

Sydnor, V. J.; Cieslak, M.; Duprat, R.; Deluisi, J.; Flounders, M. W.; Long, H.; Scully, M.; Balderston, N. L.; Sheline, Y. I.; Bassett, D. S.; Satterthwaite, T. D.; Oathes, D. J.

10.1101/2021.11.12.468411 — neuroscience — Posted on 2022-04-03

3472 Viability of AMURA biomarkers from single-shell diffusion MRI in Migraine Clinical Studies

Martin-Martin, C.; Planchuelo-Gomez, A.; Guerrero, A. L.; Garcia-Azorin, D.; Tristan-Vega, A.; de Luis-Garcia, R.; Aja-Fernandez, S.

10.1101/2022.04.01.486661 — neuroscience — Posted on 2022-04-03

3473 Prediction of designer-recombinases for DNA editing with generative deep learning

Schmitt, L. T.; Paszkowski-Rogacz, M.; Jug, F.; Buchholz, F.

10.1101/2022.04.01.486669 — bioinformatics — Posted on 2022-04-03

3474 Near-neutral pH increased n-caprylate production in a microbiome with product inhibition of methanogenesis

Palomo-Briones, R.; Xu, J.; Spirito, C. M.; Usack, J. G.; Trondsen, L. H.; Guzman, J. J. L.; Angenent, L. T.

10.1101/2022.04.01.486710 — bioengineering — Posted on 2022-04-03

3475 Evolutionary adaptation of the folding pathway for secretability

Smets, D.; Tsirigotaki, A.; Smit, J. H.; Krishnamurthy, S.; Portaliou, A.; Vorobieva, A.; Vranken, W.; Karamanou, S.; Economou, A.

10.1101/2022.04.03.486881 — biochemistry — Posted on 2022-04-03

3476 Protein-Peptide Turnover Profiling reveals wiring of phosphorylation during protein maturation

Hammaren, H. M.; Geissen, E.-M.; Potel, C.; Beck, M.; Savitski, M. M.

10.1101/2022.04.03.486883 — biochemistry — Posted on 2022-04-03

3477 Loss-of-function mutations in novel triacylglycerol lipase genes are associated with low rancidity in pearl millet flour

Aher, R. R.; Reddy, P. S.; Bhunia, R. K.; Flyckt, K. S.; Shankhapal, A. R.; Ojha, R.; Everard, J. D.; Wayne, L. L.; M. Ruddy, B.; Deonovic, B.; K. Gupta, S.; Sharma, K. K.; Bhatnagar-Mathur, P.

10.1101/2022.04.02.486827 — biochemistry — Posted on 2022-04-03

3478 Deciphering Multi-way Interactions in the Human Genome

Dotson, G. A.; Lindsly, S. M.; Cicalo, A.; Chen, C.; Dilworth, S.; Ryan, C.; Jeyarajan, S.; Meixner, W.; Beckloff, N.; Surana, A.; Wicha, M.; Muir, L.; Rajapakse, I.

10.1101/2021.08.15.456363 — genomics — Posted on 2022-04-03

3479 Combining GWAS and TWAS to identify candidate causal genes for tocochromanol levels in maize grain

Wu, D.; Li, X.; Tanaka, R.; Wood, J. C.; Tibbs-Cortes, L. E.; Magallanes-Lundback, M.; Bornowski, N.; Hamilton, J. P.; Vaillancourt, B.; Diepenbrock, C. H.; Li, X.; Deason, N. T.; Schoenbaum, G. R.; Yu, J.; Buell, C. R.; DellaPenna, D.; Gore, M. A.

10.1101/2022.04.01.486706 — genetics — Posted on 2022-04-03

3480 The Bcvic1 and Bcvic2 vegetative incompatibility genes in Botrytis cinerea encode proteins with domain architectures involved in allorecognition in other filamentous fungi

Arshed, S.; Cox, M. P.; Beever, R. E.; Parkes, S. L.; Pearson, M. N.; Bowen, J. K.; Templeton, M. D.

10.1101/2022.04.03.486892 — genetics — Posted on 2022-04-03

3481 Allele mining, evolutionary genetic analysis of TaHKT1;5 gene and evaluation of salinity stress in selected lines of wheat.

Thiyagarajan, K.; Mathur, P. N.; Vikram, P.; Sehgal, D.; Valluru, R.; Govindan, V.; Rahman, H.; Thapa, D. B.; Pantha, S.; Galeffi, P.; Latini, A.; Cantale, C.; Porceddu, E.; Joshi, A. K.

10.1101/2022.04.01.486792 — genetics — Posted on 2022-04-03

3482 Asexual male production by ZW recombination in Artemia parthenogenetica

Boyer, L.; Jabbour-Zahab, R.; Joncour, P.; Glemin, S.; Haag, C. R.; Lenormand, T.

10.1101/2022.04.01.486774 — evolutionary biology — Posted on 2022-04-03

3483 Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8

Wang, N.; He, J.; Feng, X.; Liao, S.; Zhao, Y.; Tang, F.; Kee, K.

10.1101/2022.04.01.486705 — developmental biology — Posted on 2022-04-03

3484 Melanization is an important antifungal defense mechanism in Galleria mellonella hosts

Smith, D. F. Q.; Dragotakes, Q.; Kulkarni, M.; Hardwick, J. M.; Casadevall, A.

10.1101/2022.04.02.486843 — microbiology — Posted on 2022-04-03

3485 Dynamics of drug response in single mycobacterial cells by microfluidic dose-response assay

Mistretta, M.; Gangneux, N.; Manina, G.

10.1101/2022.04.03.486879 — microbiology — Posted on 2022-04-03

3486 CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice

Fried, J.; Paul, M.; Jing, Z.; Fooksman, D.; Lauvau, G.

10.1101/2022.04.03.486895 — immunology — Posted on 2022-04-03

3487 Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature upon SARS-CoV-2 sensing by monocytes in COVID-19

Maher, A. K.; Burnham, K. L.; Jones, E.; Baillon, L.; Selck, C.; Giang, N.; Argüello, R. J.; Short, C.-E.; Quinlan, R.; Barclay, W. S.; Cooper, N.; Taylor, G. P.; Davenport, E. E.; Dominguez-Villar, M.

10.1101/2022.04.03.486830 — immunology — Posted on 2022-04-03

3488 M2e-specific monoclonal antibody cocktails against influenza A virus are superior to individual monoclonal antibody treatments, universally effective, and viral escape mutant resistant

Bimler, L. H.; Kim, T.; Ronzulli, S. L.; Song, A. Y.; Johnson, S. K.; Jones, C. A.; Tompkins, S. M.; Paust, S.

10.1101/2022.04.02.486847 — immunology — Posted on 2022-04-03

3489 VMHdm/cSF-1 Neuronal Circuits Regulate Skeletal Muscle PGC1-α via the Sympathoadrenal Drive

Takuya, T.; Farmer, S.; Harada, A.; Shi, Z.; Lee, J. J.; Tinajero, A.; Singha, A. K.; Fujikawa, T.

10.1101/2022.04.01.486756 — neuroscience — Posted on 2022-04-03

3490 Harnessing cellular perception apparatus for smart metabolic reprogramming

Chunlin, T.; Tao, F.; Xu, P.

10.1101/2022.04.03.486851 — synthetic biology — Posted on 2022-04-03

3491 Modulation of Receptor-like Trans-Membrane Kinase 1 nuclear localisation by DA1 peptidases in Arabidopsis.

Gu, B.; Dong, H.; Smith, C.; Bevan, M. W.

10.1101/2022.04.01.486729 — plant biology — Posted on 2022-04-03

3492 NSMCE2, a Novel Super-Enhancer Regulated Gene, is Linked to Poor Prognosis and Therapy Resistance in Breast Cancer

Di Benedetto, C.; Oh, J.; Choidhery, Z.; Shi, W.; Valdes, G.; Betancur, P.

10.1101/2022.04.01.486781 — cancer biology — Posted on 2022-04-03

3493 Farnesyltransferase inhibition overcomes the adaptive resistance to osimertinib in EGFR-mutant NSCLC

Figarol, S.; Delahaye, C.; Gence, R.; Asslan, R.; Pagano, S.; Tardy, C.; Colinge, J.; Villemin, J.-P.; Maraver, A.; Ferrer, I.; Paz-Ares, L.; Lajoie-Mazenc, I.; Clermont, E.; Casanova, A.; Pradines, A.; Mazieres, J.; Calvayrac, O.; Favre, G.

10.1101/2022.04.01.486707 — cancer biology — Posted on 2022-04-03

3494 Clonal Dynamics of Cancer-Initiating Cells in a Mouse Genetic Mosaic Model of Serous Ovarian Cancer

Zeng, J.; Casarez, E.; Jiang, Y.; Yela, A. A.; Wang, L.; Kelly, B. E.; Ke, E.; Jenkins, T. M.; Atkins, K. A.; Janes, K. A.; Slack-Davis, J. K.; Zong, H.

10.1101/2022.01.23.477434 — cancer biology — Posted on 2022-04-03

3495 Structure Determination of Inactive-State GPCRs with a Universal Nanobody

Robertson, M. J.; Papasergi-Scott, M. M.; He, F.; Seven, A. B.; Meyerowitz, J. G.; Panova, O.; Peroto, M.-C.; Che, T.; Skiniotis, G.

10.1101/2021.11.02.466983 — biophysics — Posted on 2022-04-03

3496 A co-operative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels

Ives, C. M.; Thomson, N. J.; Zachariae, U.

10.1101/2022.04.01.486690 — biophysics — Posted on 2022-04-03

3497 SEACells: Inference of transcriptional and epigenomic cellular states from single-cell genomics data

Persad, S.; Choo, Z.-N.; Dien, C.; Masilionis, I.; Chaligne, R.; Nawy, T.; Brown, C. C.; Pe'er, I.; Setty, M.; Pe'er, D.

10.1101/2022.04.02.486748 — bioinformatics — Posted on 2022-04-03

3498 SIMBA: SIngle-cell eMBedding Along with features

Chen, H.; Ryu, J.; Vinyard, M. E.; Lerer, A.; Pinello, L.

10.1101/2021.10.17.464750 — bioinformatics — Posted on 2022-04-03

3499 Molecular basis of neurodevelopmental disorder-causing mutation in nonsense-mediated mRNA decay factor UPF3B

Bufton, J. C.; Powers, K. T.; Szeto, J.-Y. A.; Schaffitzel, C.

10.1101/2022.04.03.486873 — biochemistry — Posted on 2022-04-03

3500 Kinetic and Redox Characterization of KRAS G12C Inhibition

Huynh, M. V.; Parsonage, D.; Forshaw, T. E.; Chirasani, V. R.; Hobbs, G. A.; Wu, H.; Lee, J.; Furdui, C. M.; Poole, L. B.; Campbell, S. L.

10.1101/2022.04.03.486828 — biochemistry — Posted on 2022-04-03

3501 Compound interaction screen on a photoactivatable cellulose membrane (CISCM) identifies drug targets

Melder, T.; Lindemann, P.; Welle, A.; Trouillet, V.; Heissler, S.; Nazare, M.; Selbach, M.

10.1101/2022.04.03.486868 — biochemistry — Posted on 2022-04-03

3502 An ancestral interaction module promotes oligomerisation in divergent mitochondrial ATP synthases

Gahura, O.; Muhleip, A.; Hierro-Yap, C.; Panicucci, B.; Jain, M.; Slapnickova, M.; Zikova, A.; Amunts, A.

10.1101/2021.10.10.463820 — molecular biology — Posted on 2022-04-03

3503 SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant

Kimura, I.; Yamasoba, D.; Nasser, H.; Zahradnik, J.; Kosugi, Y.; Wu, J.; Nagata, K.; Uriu, K.; Tanaka, Y. L.; Ito, J.; Shimizu, R.; Tan, T. S.; Butlertanaka, E. P.; Asakura, H.; Sadamasu, K.; Yoshimura, K.; Ueno, T.; Takaori-Kondo, A.; Schreiber, G.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Toyoda, M.; Shirakawa, K.; Irie, T.; Saito, A.; Nakagawa, S.; Ikeda, T.; Sato, K.

10.1101/2022.04.03.486864 — microbiology — Posted on 2022-04-03

3504 Conformational Flexibility in Neutralization of SARS-CoV-2 by Naturally Elicited Anti-SARS-CoV-2 Antibodies

Li, R.; Mor, M.; Ma, B.; Clark, A. E.; Alter, J.; Werbner, M.; Lee, J.; Leibel, S. L.; Carlin, A. F.; Dassau, M.; Gal-Tanamy, M.; Croker, B. A.; Xiang, Y.; Freund, N. T.

10.1101/2022.04.03.486854 — immunology — Posted on 2022-04-03

3505 A multi-dataset evaluation of frame censoring for motion correction in task-based fMRI

Jones, M. S.; Zhu, Z.; Bajracharya, A.; Luor, A.; Peelle, J. E.

10.1101/2021.10.12.464075 — neuroscience — Posted on 2022-04-03

3506 RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia

McMillan, M.; Gomez, N.; Bekier, M.; Li, X.; Miguez, R.; Tank, E. M.; Barmada, S.

10.1101/2022.04.03.486880 — neuroscience — Posted on 2022-04-03

3507 Dietary αKG inhibits SARS CoV-2 infection and rescues inflamed lungs to restore normal O2 saturation in animals

Agarwal, S.; Kaur, S.; Asuru, T. R.; Joshi, G.; Shrimali, N. M.; Singh, A.; Singh, O. N.; Srivastva, P.; Shrivastava, T.; Vrati, S.; Surjit, M.; Guchhait, P.

10.1101/2022.04.02.486853 — pathology — Posted on 2022-04-03

3508 Single voxel autocorrelation uncovers gradients of temporal dynamics in the hippocampus and entorhinal cortex during rest and navigation

Bouffard, N. R.; Golestani, A. R.; Brunec, I. K.; Bellana, B.; Park, J. Y.; Barense, M. D.; Moscovitch, M.

10.1101/2021.07.28.454036 — neuroscience — Posted on 2022-04-03

3509 Haplotype and Population Structure Inference using Neural Networks in Whole-Genome Sequencing Data

Meisner, J.; Albrechtsen, A.

10.1101/2020.12.28.424587 — bioinformatics — Posted on 2022-04-03

3510 Efflux-linked Accelerated Evolution of Antibiotic Resistance at a Population Edge

Bhattacharyya, S.; Bhattacharyya, M.; Nandi, A. K.; Pfannenstiel, D. M.; Hwang, Y.; Ho, K.; Harshey, R. M.

10.1101/2022.04.01.486762 — microbiology — Posted on 2022-04-03

3511 Modulation of the extracellular matrix by Streptococcus gallolyticus subsp. gallolyticus and importance in cell proliferation

Kumar, R.; Taylor, J.; Jain, A.; Jung, S. Y.; Xu, Y.

10.1101/2022.03.14.484142 — microbiology — Posted on 2022-04-03

3512 An energy-dissipative state of the major antenna complex of plants

Bru, P.; Steen, C. J.; Park, S.; Amstutz, C. L.; Sylak-Glassman, E. J.; Lam, L.; Fekete, A.; Mueller, M. J.; Longoni, F.; Fleming, G. R.; Niyogi, K. K.; Malnoë, A.

10.1101/2021.07.09.450705 — plant biology — Posted on 2022-04-03

3513 RNA-sequencing manifests the intrinsic role of MAPKAPK2 in facilitating molecular crosstalk during HNSCC pathogenesis

Soni, S.; Anand, P.; Swarnakar, M. K.; Patial, V.; Tirpude, N. V.; Padwad, Y. S.

10.1101/2020.09.22.303180 — cancer biology — Posted on 2022-04-03

3514 A single-cell clusters similarity measure for different batches, datasets, and samples

Gonzalez-Velasco, O.; Sanchez-Luis, E.; De La Rosa, E.; Sanchez-Santos, J. M.; De Las Rivas, J.

10.1101/2022.03.14.483731 — bioinformatics — Posted on 2022-04-03

3515 Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina

Babu, S.; Takeuchi, Y.; Masai, I.

10.1101/2021.11.03.467208 — cell biology — Posted on 2022-04-03

3516 CryoGrid-PIXUL-RNA: High throughput RNA isolation platform for tissue transcript analysis

Schactler, S. A.; Scheuerman, S. J.; Lius, A.; Altemeier, W. A.; An, D.; Matula, T. J.; Mikula, M.; Kulecka, M.; Denisenko, O.; Mar, D.; Bomsztyk, K.

10.1101/2022.04.01.486750 — molecular biology — Posted on 2022-04-03

3517 The Effect of Task on Object Processing revealed by EEG decoding

Yip, H. M. K.; Cheung, L. Y. T.; Ngan, V. S. H.; Wong, Y. K.; Wong, A. C.- N.

10.1101/2020.08.18.255018 — neuroscience — Posted on 2022-04-03

3518 Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion

Huang, C.-K.; Yong, X.; She, D.; Lim, C. T.

10.1101/2022.04.01.486717 — cell biology — Posted on 2022-04-03

3519 A dual mechanism of APC/C inhibition by MAP kinases

Sun, L.; Bai, S.; Chen, J.-l.; Deng, D.-j.; Luo, Z.-q.; Wang, Y.; JIN, Q.

10.1101/2022.04.01.485959 — cell biology — Posted on 2022-04-03

3520 Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

Sokoya, T.; Parolek, J.; Foged, M. M.; Danylchuk, D. I.; Bozan, M.; Sarkar, B.; Hilderink, A.; Philippi, M.; Botto, L. D.; Terhal, P. A.; Maekitie, O.; Piehler, J.; Kim, Y.; Burd, C. G.; Klymchenko, A. S.; Maeda, K.; Holthuis, J. C. M.

10.1101/2022.04.02.486804 — cell biology — Posted on 2022-04-03

3521 Death-seq identifies regulators of cell death and senolytic therapies

Colville, A.; Liu, J.-Y.; Thomas, S.; Ishak, H. D.; Zhou, R.; Klein, J. D. D.; Morgens, D. W.; Goshayeshi, A.; Salvi, J. S.; Yao, D.; Spees, K.; Bassik, M. C.; Rando, T. A.

10.1101/2022.04.01.486768 — cell biology — Posted on 2022-04-03

3522 A Locally Activatable Sensor for Robust Quantification of Organellar Glutathione

Hübner, S.; Quargnali, G.; Thallmair, S.; Rivera-Fuentes, P.

10.1101/2022.04.01.486692 — cell biology — Posted on 2022-04-03

3523 Reduced mitochondria provide an essential function for the cytosolic methionine cycle

Zitek, J.; Füssy, Z.; Treitli, S. C.; Pena-Diaz, P.; Vaitova, Z.; Zavadska, D.; Harant, K.; Hampl, V.

10.1101/2022.04.01.486701 — cell biology — Posted on 2022-04-03

3524 FCHO controls AP2's critical endocytic roles through a PtdIns4,5P2 membrane-dependent switch

Zaccai, N. R.; Kadlecova, Z.; Kane Dickson, V.; Korobchevskaya, K.; Kamenicky, J.; Kovtun, O.; Umasankar, P. K.; Wrobel, A. G.; Kaufman, J. G. G.; Gray, S. R.; Qu, K.; Evans, P. R.; Fritzsche, M.; Sroubek, F.; Höning, S.; Briggs, J. A. G.; Kelly, B. T.; Owen, D. J.; Traub, L. M.

10.1101/2022.04.02.486817 — cell biology — Posted on 2022-04-03

3525 A retrospective and stepwise learning strategy revealed by neuronal activity in the basal forebrain

Manzur, H. E.; Vlasov, K.; Lin, S.-C.

10.1101/2022.04.01.486795 — neuroscience — Posted on 2022-04-03

3526 Dual pathway architecture underlying vocal learning in songbirds

Sankar, R.; Leblois, A.; Rougier, N. P.

10.1101/2022.04.02.486814 — neuroscience — Posted on 2022-04-03

3527 TP53 somatic mutations in Asian breast cancer are associated with subtype-specific effects

Ragu, M. E.; Lim, J. M. C.; Ng, P.-S.; Yip, C.-H.; Rajadurai, P.; Teo, S.-H.; Pan, J.-W.

10.1101/2022.03.31.486643 — cancer biology — Posted on 2022-04-02

3528 DeepAcr: Predicting Anti-CRISPR with Deep Learning

Li, Y.; Wei, Y.; Tan, Q.; Zong, L.; Wang, Y.; Chen, J.; Li, Y.

10.1101/2022.04.02.486820 — bioinformatics — Posted on 2022-04-02

3529 Approximations to the expectations and variances of ratios of tree properties under the coalescent

Lappo, E.; Rosenberg, N. A.

10.1101/2022.04.01.486796 — genetics — Posted on 2022-04-02

3530 Artificial selection methods from evolutionary computing show promise for directed evolution of microbes

Lalejini, A.; Dolson, E.; Vostinar, A. E.; Zaman, L.

10.1101/2022.04.01.486727 — evolutionary biology — Posted on 2022-04-02

3531 IMC10 and LMF1 mediate membrane contact between the mitochondrion and the inner membrane complex in Toxoplasma gondii

Souza, R. O. O.; Arrizabalaga, G.; Jacobs, K. N.

10.1101/2022.04.01.486766 — microbiology — Posted on 2022-04-02

3532 Reduced cutaneous CD200:CD200R1 signalling in psoriasis enhances neutrophil recruitment to skin

Linley, H.; Jaigirdar, S.; Mohamed, K.; Griffiths, C. E.; Saunders, A.

10.1101/2022.04.01.486720 — immunology — Posted on 2022-04-02

3533 Computational design and construction of an Escherichia coli strain engineered to produce a non-standard amino acid

Zomorrodi, A. R.; Hemez, C.; Arranz-Gibert, P.; Wu, T.; Isaacs, F. J.; Segre, D.

10.1101/2022.04.02.486821 — systems biology — Posted on 2022-04-02

3534 Microgravity enhances the phenotype of Arabidopsis zigzag-1 and reduces the Wortmannin-induced vacuole fusion in root cells

Wang, M.; Danz, K.; Ly, V.; Rojas-Pierce, M.

10.1101/2022.04.01.486597 — plant biology — Posted on 2022-04-02

3535 Oncogenic mutations in the DNA-binding domain of FOXO1 disrupt folding: quantitative insights from experiments and molecular simulations

Novack, D. A.; Qian, L.; Acker, G.; Voelz, V. A.; Baxter, R. H. G.

10.1101/2022.04.01.486713 — cancer biology — Posted on 2022-04-02

3536 Clinically-relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

Manas, A.; Aaltonen, K.; Anderson, N.; Hansson, K.; Adamska, A.; Seger, A.; Yasui, H.; van den Bos, H.; Radke, K.; Esfandyari, J.; Bhave, M. S.; Karlsson, J.; Spierings, D. C. J.; Foijer, F.; Gisselsson, D.; Bexell, D.

10.1101/2022.04.01.486670 — cancer biology — Posted on 2022-04-02

3537 Highly multiplexed targeted plasma proteomics quantifies several hundred blood proteins in serum from colorectal carcinoma patients

Lesur, A.; Bernardin, F.; Koncina, E.; Letellier, E.; Kruppa, G.; Schmit, P.-O.; Dittmar, G.

10.1101/2022.04.01.486663 — biochemistry — Posted on 2022-04-02

3538 Cotranslational folding and assembly of the dimeric E. coli inner membrane protein EmrE

Mermans, D.; Nicolaus, F.; Fleisch, K.; von Heijne, G.

10.1101/2022.04.02.486806 — biochemistry — Posted on 2022-04-02

3539 Appia: a web interface for chromatography

Posert, R.; Hartfield, K.; Baconguis, I.

10.1101/2022.04.01.486784 — biochemistry — Posted on 2022-04-02

3540 Unifying genetic association tests via regression: Prospective and retrospective, parametric and non-parametric, and genotype- and allele-based tests

Zhang, L.; Sun, L.

10.1101/2022.03.31.486648 — genomics — Posted on 2022-04-02

3541 Xport-A functions as a chaperone by stabilizing the first 5 transmembrane domains of Rhodopsin-1

Gaspar, C. J.; Martins, J. C.; Melo, M. N.; Cordeiro, T. N.; Adrain, C.; Domingos, P. M.

10.1101/2022.04.01.486763 — cell biology — Posted on 2022-04-02

3542 Mmp14-controlled extracellular matrix homeostasis is required for circadian rhythm

GARVA, R.; Yeung, C.-Y. C.; Pickard, A.; Lu, Y.; Mallikarjun, V.; Swift, J.; Taylor, S. H.; Rai, J.; Eyre, D. R.; Chaturvedi, M.; Itoh, Y.; Meng, Q.-J.; Mauch, C.; Zigrino, P.; Kadler, K. E.

10.1101/2022.04.01.486699 — cell biology — Posted on 2022-04-02

3543 Control of pancreatic islet function and glucose homeostasis by a novel microexon program misregulated in type 2 diabetes

Juan-Mateu, J.; Bajew, S.; Miret, M.; Iniguez, L. P.; Lopez, A.; Bonnal, S.; Atla, G.; Bonas-Guarch, S.; Ferrer, J.; Valcarcel, J.; Irimia, M.

10.1101/2022.04.02.486809 — molecular biology — Posted on 2022-04-02

3544 The fluorescence-activating and absorption-shifting tag (FAST) enables live-cell fluorescence imaging of Methanococcus maripaludis

Hernandez, E.; Costa, K.

10.1101/2022.04.01.486799 — microbiology — Posted on 2022-04-02

3545 Extensive heterogeneity of the HIV-1 infected CD4+ T-cell reservoir revealed by single-cell viral ASAPseq

Wu, V. H.; Nguyen, S.; Nordin, J. M. L.; Joy, J.; Mampe, F.; M. del Rio Estrada, P.; Torres-Ruiz, F.; Gonzalez-Navarro, M.; Andrea Luna-Villalobos, Y.; Avila-Rios, S.; Reyes-Teran, G.; Tebas, P.; Montaner, L. J.; Bar, K. J.; Vella, L. A.; Betts, M. R.

10.1101/2022.04.02.486753 — microbiology — Posted on 2022-04-02

3546 Activation of the integrative and conjugative element Tn916 causes growth arrest and death of host bacteria

Bean, E. L.; McLellan, L. K.; Grossman, A. D.

10.1101/2022.04.01.486793 — microbiology — Posted on 2022-04-02

3547 Novel Requirement for Staphylococcal Cell Wall-Anchored Protein SasD in Pulmonary Infection

Grousd, J. A.; Riesmeyer, A. M.; Cooper, V. S.; Bomberger, J. M.; Richardson, A. R.; Alcorn, J. F.

10.1101/2022.04.01.486802 — microbiology — Posted on 2022-04-02

3548 Robust Variation in Infant Gut Microbiome Assembly Across a Spectrum of Lifestyles

Olm, M. R.; Dahan, D.; Carter, M. M.; Merrill, B. D.; Yu, B.; Jain, S.; Meng, X. D.; Tripathi, S.; Wastyk, H.; Neff, N.; Holmes, S.; Sonnenburg, E. D.; Jha, A. R.; Sonnenburg, J. L.

10.1101/2022.03.30.486467 — microbiology — Posted on 2022-04-02

3549 The WalRK Two-component system is Essential for Proper Cell Envelope Biogenesis in Clostridioides difficile

Muh, U.; Ellermeier, C. D.; Weiss, D. S.

10.1101/2022.04.01.486798 — microbiology — Posted on 2022-04-02

3550 Pleiotrophin signals through ALK receptor to enhance growth of neurons in the presence of inhibitory CSPGs

Gupta, S. J.; Churchward, M. A.; Todd, K. G.; Winship, I. R.

10.1101/2022.04.01.486745 — neuroscience — Posted on 2022-04-02

3551 Modulation of C5a-C5aR1 signaling alters the dynamics of AD progression

Carvalho, K.; Schartz, N. D.; Balderrama-Gutierrez, G.; Liang, H. Y.; Chu, S.-H.; Selvan, P.; Gomez-Arboledas, A.; Petrisko, T.; Fonseca, M. I.; Mortazavi, A.; Tenner, A. J.

10.1101/2022.04.01.486759 — neuroscience — Posted on 2022-04-02

3552 Building molecular band-pass filters via molecular sequestration

Zhang, Y.; Cuba Samaniego, C.; Carleton, K.; Qian, Y.; Giordano, G.; Franco, E.

10.1101/2022.04.02.486709 — synthetic biology — Posted on 2022-04-02

3553 The optimal strategy of incompatible insect technique (IIT) using Wolbachia to control Malaria

Matsufuji, T.; Seirin-Lee, S.

10.1101/2022.04.02.486813 — pathology — Posted on 2022-04-02

3554 Engineering a more specific E. coli glyoxylate/hydroxypyruvate reductase for coupled steady state kinetics assays

Vuksanovic, N.; Serrano, D. A.; Patterson, B. R.; Silvaggi, N. R.

10.1101/2022.04.02.486822 — biochemistry — Posted on 2022-04-02

3555 Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

Belser, J. A.; Lau, E. H.; Barclay, W.; Barr, I. G.; Chen, H.; Fouchier, R. A.; Hatta, M.; Herfst, S.; Kawaoka, Y.; Lakdawala, S. S.; Lee, L. Y. Y.; Neumann, G.; Peiris, M.; Perez, D. R.; Russell, C. J.; Subbarao, K.; Sutton, T. C.; Webby, R. J.; Yang, H.; Yen, H.-L.; Bestebroer, T.; Bhagwat, A.; Blanchard, E.; Caceres, C. J.; Carnaccini, S.; Chiba, S.; Choy, K.-T.; DeBeauchamp, J. L.; de Meulder, D.; Ferreri, L. M.; Frise, R.; Geiger, G.; Hu, M.; Hurt, A. C.; Jeevan, T.; Jones, J. E.; Kercher, L. A.; Kormuth, K. A.; Le Sage, V.; Lexmond, P.; Li, C.; Maines, T. R.; Patel, D. R.; Septer, K. M.;

10.1101/2022.04.02.486825 — microbiology — Posted on 2022-04-02

3556 Extracellular Vesicle (EV) Mitochondria and EV/HSP27 Mixtures Protect the Ischemic Brain Endothelium

Dave, K.; Stolz, D. B.; Reynolds, M. J.; Babidhan, R.; Dobbins, D. X.; Yankello, H.; Reddy, R.; Bae, Y.; Shiva, S.; Soundara Manickam, D.

10.1101/2021.10.29.466491 — bioengineering — Posted on 2022-04-02

3557 Large-scale algorithmic search identifies stiff and sloppy dimensions in synaptic architectures consistent with murine neocortical wiring

Jabri, T.; MacLean, J. N.

10.1101/2021.11.13.468127 — neuroscience — Posted on 2022-04-02

3558 Unsupervised cell functional annotation for single-cell RNA-Seq

Li, D.; Ding, J.; Bar-Joseph, Z.

10.1101/2021.11.20.469410 — bioinformatics — Posted on 2022-04-02

3559 Random peptides rich in small and disorder-promoting amino acids are less likely to be harmful

Kosinski, L.; Aviles, N. R.; Gomez, K.; Masel, J.

10.1101/2020.04.28.066316 — evolutionary biology — Posted on 2022-04-02

3560 Interaction of human Crx and Nrl in live cells measured using fluorescence resonance energy transfer (FRET)

Knox, B. E.; Zhuo, X.

10.1101/2021.10.19.465002 — biochemistry — Posted on 2022-04-02

3561 Inter-Individual Variability in Dorsal Stream Dynamics During Word Production

Liegeois-Chauvel, C.; Dubarry, A.-S.; Wang, I. Z.; Chauvel, P.; Gonzalez-Martinez, J.; Alario, F.- X.

10.1101/2022.04.01.486723 — neuroscience — Posted on 2022-04-02

3562 Explaining flexible continuous speech comprehension from individual motor rhythms

Lubinus, C.; Keitel, A.; Obleser, J.; Poeppel, D.; Rimmele, J.

10.1101/2022.04.01.486685 — neuroscience — Posted on 2022-04-02

3563 Late maturation of executive control promotes conceptual development

Jackson, R. L.; Lambon Ralph, M. A.; Rogers, T. T.

10.1101/2022.03.31.486559 — neuroscience — Posted on 2022-04-02

3564 Ion channel distributions in cortical neurons are optimized for energy-efficient active dendritic computations

Bast, A.; Oberlaender, M.

10.1101/2021.12.11.472235 — neuroscience — Posted on 2022-04-02

3565 Injury risk functions for the four primary knee ligaments

Nusia, J.; Xu, J. C.; Sjöblom, R.; Knälmann, J.; Linder, A.; Kleiven, S.

10.1101/2021.07.30.454445 — bioengineering — Posted on 2022-04-02

3566 Spatial-CITE-seq: spatially resolved high-plex protein and whole transcriptome co-mapping

Liu, Y.; Distasio, M.; Su, G.; Asashima, H.; Enninful, A.; Qin, X.; Deng, Y.; Bordignon, P.; Cassano, M.; Tomayko, M.; Xu, M. L.; Halene, S.; Craft, J. E.; Hafler, D. A.; Fan, R.

10.1101/2022.04.01.486788 — genomics — Posted on 2022-04-02

3567 Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila

Yamada, D.; Bushey, D.; Li, F.; Hibbard, K.; Sammons, M.; Funke, J.; Litwin-Kumar, A.; Hige, T.; Aso, Y.

10.1101/2022.03.30.486484 — neuroscience — Posted on 2022-04-02

3568 CryoGrid-PIXUL-RNA: High throughput RNA isolation platform for tissue transcript analysis

Schactler, S. A.; Scheuerman, S. J.; Lius, A.; Altemeier, W. A.; An, D.; Matula, T. J.; Mikula, M.; Maria Kulecka, M.; Denisenko, O.; Mar, D.; Bomsztyk, K.

10.1101/2022.04.01.486750 — molecular biology — Posted on 2022-04-01

3569 Linking individual differences in human primary visual cortex to contrast sensitivity around the visual field

Himmelberg, M. M.; Winawer, J.; Carrasco, M.

10.1101/2021.10.04.463138 — neuroscience — Posted on 2022-04-02

3570 Long-range cortical synchronization supports abrupt visual learning

Csorba, B. A.; Krause, M. R.; Zanos, T. P.; Pack, C. C.

10.1101/2021.08.03.454994 — neuroscience — Posted on 2022-04-02

3571 A novel anti-PD-L1/IL-15 immunocytokine overcomes resistance to PD-L1 blockade and elicits potent antitumor immunity

Shi, W.; Lv, L.; Liu, N.; Wang, H.; Wang, Y.; Zhu, W.; Liu, Z.; Zhu, J.; Lu, H.

10.1101/2022.03.15.484441 — immunology — Posted on 2022-04-01

3572 Medial prefrontal-hippocampal concordance in child-parent dyads underlies children's psychological wellbeing

Su, H.; Young, C. B.; Han, Z. R.; Xu, J.; Xiong, B.; Wang, J.; Hao, L.; Yang, Z.; Chen, G.; Qin, S.

10.1101/2022.03.30.486310 — neuroscience — Posted on 2022-04-01

3573 Web-based Histology Reference Atlas for the Freshwater Crustacean Daphnia magna

Ngu, M. S.; Vanselow, D. X.; Zaino, C. R.; Lin, A. Y.; Copper, J. E.; Beaton, M.; Colbourne, J. K.; Cheng, K. C.; Ang, K. C.

10.1101/2022.03.09.483544 — zoology — Posted on 2022-04-01

3574 Overexpression of the WAPO-A1 gene increases the number of spikelets per spike in bread wheat

Wittern, L. M.; Barrero, J. M.; Bovill, W. D.; Verbyla, K. L.; Hughes, T.; Swain, S. M.; Steed, G.; Webb, A. A.; Gardner, K.; Jacobs, J.; Frohberg, C.; Schmidt, R.-C.; Cavanagh, C.; Rohde, A.; Davey, M.; Hannah, M. A.

10.1101/2022.04.01.486512 — plant biology — Posted on 2022-04-01

3575 DeepVelo: Data-driven Single-cell Transcriptomic Deep Velocity Field Learning with Neural Ordinary Differential Equations

Chen, Z.; King, W. C.; Gerstein, M.; Zhang, J.

10.1101/2022.02.15.480564 — bioinformatics — Posted on 2022-04-01

3576 Pathways to polar adaptation in fishes revealed by long-read sequencing

Hotaling, S.; Desvignes, T.; Sproul, J. S.; Lins, L. S. F.; Kelley, J. L.

10.1101/2021.11.12.468413 — genomics — Posted on 2022-04-01

3577 Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector

Ibrahim, S. S.; Muhammad, A.; Hearn, J.; Weedall, G. D.; Nagi, S. C.; Mukhtar, M. M.; Fadel, A. N.; Mugenzi, L. J.; Patterson, E. I.; Irving, H.; Wondji, C. S.

10.1101/2022.03.21.485146 — genomics — Posted on 2022-04-01

3578 Allopeptimicins: unique antibacterial metabolites generated by hybrid PKS-NRPS, with original self-defense mechanism in Actinoallomurus

Iorio, M.; Gentile, A.; Brunati, C.; Tocchetti, A.; Landini, P.; Maffioli, S. I.; Donadio, S.; Sosio, M.

10.1101/2022.04.01.486743 — microbiology — Posted on 2022-04-01

3579 Bacterial threat assessment of bacteriophage infection is mediated by intracellular polyamine accumulation and Gac/Rsm signaling

de Mattos, C. D.; Nemudryi, A.; Faith, D.; Bublitz, D. C.; Hammond, L.; Kinnersley, M.; Schwartzkopf, C. M.; Robinson, A. J.; Joyce, A.; Michaels, L. A.; Brzozowski, R.; Coluccio, A.; Xing, D.; Uchiyama, J.; Jennings, L. K.; Eswara, P. J.; Wiedenheft, B.; Secor, P. R.

10.1101/2022.04.01.486733 — microbiology — Posted on 2022-04-01

3580 Efflux-linked Accelerated Evolution of Antibiotic Resistance at a Population Edge

Harshey, R. M.; Bhattacharyya, S.; Bhattacharyya, M.; Nandi, A. K.; Hwang, Y.; Ho, K.; Pfannenstiel, D. M.

10.1101/2022.04.01.486762 — microbiology — Posted on 2022-04-01

3581 Distinct gene expression by expanded clones of quiescent memory CD4+ T cells harboring intact latent HIV-1 proviruses

Weymar, G. H.; Bar-On, Y.; Oliveira, T. Y.; Gaebler, C.; Ramos, V.; Hartweger, H.; Breton, G.; Caskey, M.; Cohn, L. B.; Jankovic, M.; Nussenzweig, M. C.

10.1101/2022.03.02.482683 — immunology — Posted on 2022-04-01

3582 Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

Mikelov, A. I.; Alekseeva, E. I.; Komech, E. A.; Staroverov, D. B.; Turchaninova, M. A.; Shugay, M.; Chudakov, D. M.; Bazykin, G. A.; Zvyagin, I. V.

10.1101/2021.12.30.474135 — immunology — Posted on 2022-04-01

3583 Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions

Zuo, Y.; Iemolo, A.; Montilla-Perez, P.; Li, H.-R.; Yang, X.; Telese, F.

10.1101/2021.11.30.470393 — neuroscience — Posted on 2022-04-01

3584 KSTAR: An algorithm to predict patient-specific kinase activities from phosphoproteomic data

Crowl, S.; Jordan, B.; Ahmed, H.; Ma, C.; Naegle, K. M.

10.1101/2021.07.06.451378 — systems biology — Posted on 2022-04-01

3585 Telomere transcription in MLL-rearranged acute leukemia: increased levels of TERRA associate with lymphoid lineage and are independent of telomere length and ploidy

Caslini, C.; Serna, A.

10.1101/2021.06.18.449032 — cancer biology — Posted on 2022-04-01

3586 dcHiC: differential compartment analysis of Hi-C datasets

Chakraborty, A.; Wang, J.; Ay, F.

10.1101/2021.02.02.429297 — bioinformatics — Posted on 2022-04-01

3587 Evolution of CRISPR-associated Endonucleases as Inferred from Resurrected Proteins

Alonso-Lerma, B.; Jabalera, Y.; Morin, M.; Fernandez, A.; Samperio, S.; Quesada-Ganuza, A.; Reifs, A.; Fernandez-Penalver, S.; Benitez, Y.; Soletto, L.; Gavira, J. A.; Diaz, A.; Vranken, W.; Kleinstiver, B. P.; Sanchez-Mejias, A.; Guell, M.; Mojica, F. J.; Moreno-Pelayo, M. A.; Montoliu, L.; Perez-Jimenez, R.

10.1101/2022.03.30.485982 — evolutionary biology — Posted on 2022-04-01

3588 Olfactory Sensitivity Aligns with Caste Revealing Multipotential Minors and Specialized Soldier Majors in Camponotus floridanus Ants

Ferguson, S. T.; Bakis, I.; Edwards, N. D.; Zwiebel, L.

10.1101/2022.04.01.486728 — evolutionary biology — Posted on 2022-04-01

3589 Topographically distinct adaptive landscapes for skulls, skeletons, and size explain the dietary adaptive radiation of Carnivora (Mammalia)

Slater, G. J.

10.1101/2022.04.01.486739 — evolutionary biology — Posted on 2022-04-01

3590 Evolution of phenotypic variance provides insights into the genetic basis of adaptation

Lai, W.-Y.; Nolte, V.; Jaksic, A. M.; Schlötterer, C.

10.1101/2021.01.19.427260 — evolutionary biology — Posted on 2022-04-01

3591 Fossils Do Not Substantially Improve, and May Even Harm, Estimates of Diversification Rate Heterogeneity

Beaulieu, J. M.; O'Meara, B. C.

10.1101/2021.11.06.467550 — evolutionary biology — Posted on 2022-04-01

3592 Artificial reefs geographical location matters more than shape, age and depth for sessile invertebrate colonization in the Gulf of Lion (NorthWestern Mediterranean Sea)

blouet, s.; Guizien, K.; Bramanti, l.

10.1101/2021.10.08.463669 — ecology — Posted on 2022-04-01

3593 A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease

Rustam, S.; Hu, Y.; Mahjour, S. B.; Randell, S. H.; Rendeiro, A. F.; Ravichandran, H.; Urso, A.; d'Ovidio, F.; Martinez, F. J.; Richmond, B.; Polosukhin, V.; Kropski, J. A.; Blackwell, T. S.; Elemento, O.; Shaykhiev, R.

10.1101/2022.03.16.484543 — cell biology — Posted on 2022-04-01

3594 Single-Molecule Analysis of DNA-binding proteins from Nuclear Extracts (SMADNE)

Schaich, M. A.; Schnable, B. L.; Kumar, N.; Roginskaya, V.; Jakielski, R. C.; Urban, R.; Zhong, Z.; Kad, N. M.; Van Houten, B.

10.1101/2022.04.01.486290 — molecular biology — Posted on 2022-04-01

3595 Comparative metagenomic analysis of biosynthetic diversity across sponge microbiomes highlights metabolic novelty, conservation and diversification

Loureiro, C.; Galani, A.; Gavriilidou, A.; de Mares, M. C.; van der Oost, J.; Medema, M. H.; Sipkema, D.

10.1101/2022.04.01.486688 — microbiology — Posted on 2022-04-01

3596 Periplasmic oxidized-protein repair during copper stress in E. coli: a focus on the metallochaperone CusF.

Vergnes, A.; Henry, C.; Grassini, G.; Loiseau, L.; El Hajj, S.; Denis, Y.; Galinier, A.; Vertommen, D.; Aussel, L.; Ezraty, B.

10.1101/2022.04.01.486667 — microbiology — Posted on 2022-04-01

3597 A 3' UTR-derived small RNA connecting nitrogen and carbon metabolism in enteric bacteria

Walling, L. R.; Kouse, A. B.; Shabalina, S. A.; Zhang, H.; Storz, G.

10.1101/2022.04.01.486790 — microbiology — Posted on 2022-04-01

3598 The Shigella type III effector protein OspB is a cysteine protease

Wood, T. E.; Westervelt, K. A.; Yoon, J. M.; Eshleman, H. D.; Burnes, H.; Levy, R.; Slade, D. J.; Lesser, C. F.; Goldberg, M. B.

10.1101/2021.09.01.458261 — microbiology — Posted on 2022-04-01

3599 Omicron breakthrough infection drives cross-variant neutralization and memory B cell formation

Quandt, J.; Muik, A.; Salisch, N.; Lui, B. G.; Lutz, S.; Krueger, K.; Wallisch, A.-K.; Adams-Quack, P.; Bacher, M.; Finlayson, A.; Ozhelvaci, O.; Vogler, I.; Grikscheit, K.; Hoehl, S.; Goetsch, U.; Ciesek, S.; Tuereci, O.; Sahin, U.

10.1101/2022.04.01.486695 — immunology — Posted on 2022-04-01

3600 Fasciola hepatica Fatty Acid Binding Protein 1 modulates T cell polarization by promoting dendritic cell thrombospondin-1 secretion without affecting metabolic homeostasis in obese mice

Zawistowska-Deniziak, A.; Lambooij, J. M.; Patente, T. A.; Lapinski, M.; van der Zande, H. J.; Basalaj, K.; de Korne, C.; Chaye, M. A.; Gasan, T.; Norbury, L. J.; Giera, M.; Zaldumbide, A.; Smits, H. H.; Guigas, B.

10.1101/2022.04.01.486671 — immunology — Posted on 2022-04-01

3601 Representations of temporal community structure in hippocampus and precuneus predict inductive reasoning decisions

Pudhiyidath, A.; Morton, N. W.; Viveros Duran, R.; Schapiro, A. C.; Momennejad, I.; Hinojosa-Rowland, D. M.; Molitor, R. J.; Preston, A. R.

10.1101/2021.10.12.462707 — neuroscience — Posted on 2022-04-01

3602 Physiopathological changes of ferritin mRNA density and distribution in hippocampal astrocytes in the mouse brain

Tortuyaux, R.; Oudart, M.; Mazare, N.; Mailly, P.; Deschemin, J. C.; Vaulont, S.; Escartin, C.; Cohen-Salmon, M.

10.1101/2022.04.01.486678 — neuroscience — Posted on 2022-04-01

3603 The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons

Ji, H.; Wang, B.; Labib, D.; Lei, J.; Chen, X.; Sapar, M.; Boulanger, A.; Dura, J.-M.; Han, C.

10.1101/2022.02.11.480148 — neuroscience — Posted on 2022-04-01

3604 Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells

Seidman, R. A.; Khattab, H.; Polanco, J. J.; Broome, J. E.; Sim, F.

10.1101/2021.09.22.461371 — neuroscience — Posted on 2022-04-01

3605 Characterization of cell-fate decision landscapes by estimating transcription factor dynamics.

Jimenez, S.; Schreiber, V.; Gradwohl, G.; Molina, N.

10.1101/2022.04.01.486696 — systems biology — Posted on 2022-04-01

3606 basicsynbio and the BASIC SEVA collection: Software and vectors for an established DNA assembly method

Haines, M. C.; Carling, B.; Marshall, J.; Shenshin, V. A.; Baldwin, G. S.; Storch, M.; Freemont, P. C.

10.1101/2022.01.06.446575 — synthetic biology — Posted on 2022-04-01

3607 Head-to-head comparison of CCN4, DNMT3A, PTPN11, and SPARC as suppressors of anti-tumor immunity

Pirkey, A. C.; Deng, W.; Norman, D.; Razazan, A.; Klinke, D. J.

10.1101/2022.04.01.486749 — cancer biology — Posted on 2022-04-01

3608 Integrative conformational ensembles of Sic1 using different initial pools and optimization methods

Gomes, G.-N.; Namini, A.; Gradinaru, C. C.

10.1101/2022.04.01.486785 — biophysics — Posted on 2022-04-01

3609 Actin turnover required for adhesion-independent bleb migration

Copos, C.; Strychalski, W.

10.1101/2022.04.01.486735 — biophysics — Posted on 2022-04-01

3610 HSD3B1 is an Oxysterol 3β-Hydroxysteroid Dehydrogenase in Human Placenta

Dickson, A.; Yutuc, E.; Thornton, C. A.; Dunford, J. E.; Oppermann, U.; Wang, Y.; Griffiths, W. J.

10.1101/2022.04.01.486576 — biochemistry — Posted on 2022-04-01

3611 USP18 is an essential regulator of muscle cell differentiation and maturation

Olie, C. S.; Pinto-Fernandez, A.; Damianou, A.; el Abdellaoui, S.; Vendrell, I.; Mei, H.; den Hamer, B.; van der Wal, E.; de Greef, J. C.; van der Kooi, A. J.; Raaphorst, J.; Aronica, E.; Raz, V.; Kessler, B. M.

10.1101/2022.04.01.486741 — cell biology — Posted on 2022-04-01

3612 Evidence that Nek1 does not phosphorylate Rad54-S572 during recovery from IR

Ghosh, I.; Khalil, M. I.; De Benedetti, A.

10.1101/2022.04.01.486731 — molecular biology — Posted on 2022-04-01

3613 Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike

Yu, X.; Juraszek, J.; Rutten, L.; Bakkers, M. J. G.; Blokland, S.; van den Broek, N. J. F.; Verwilligen, A. Y. W.; Abeywickrema, P.; Vingerhoets, J.; Neefs, J.-M.; Bakhash, S. A. M.; Roychoudhury, P.; Greninger, A.; Sharma, S.; Langedijk, J. P. M.

10.1101/2022.03.31.486561 — molecular biology — Posted on 2022-04-01

3614 The temporal transcriptomic signature of cartilage formation

Takacs, R. A.; Vago, J.; Poliska, S.; Pushparaj, P. N.; Kovacs, P.; Jin, E.-J.; Barrett-Jolley, R.; Zakany, R.; Matta, C.

10.1101/2022.04.01.486765 — molecular biology — Posted on 2022-04-01

3615 Feedback linking cell envelope stiffness, curvature, and synthesis enables robust rod-shaped bacterial growth

al-Mosleh, S.; Gopinathan, A.; Santangelo, C.; Huang, K. C.; Rojas, E.

10.1101/2022.04.01.486519 — microbiology — Posted on 2022-04-01

3616 GTP-bound E. coli FtsZ filaments are composed of Tense monomers: A DNP NMR study using interface detection.

McCoy, K. M.; McDermott, A. E.

10.1101/2022.04.01.486622 — microbiology — Posted on 2022-04-01

3617 Surface microbiota of Mediterranean loggerhead sea turtles unravelled by 16S and 18S amplicon sequencing

Kanjer, L.; Filek, K.; Mucko, M.; Majewska, R.; Gracan, R.; Trotta, A.; Panagopoulou, A.; Corrente, M.; Di Bello, A.; Bosak, S.

10.1101/2022.04.01.486708 — microbiology — Posted on 2022-04-01

3618 Functional Biomarkers of Ex-vivo Dental Caries Onset

Moussa, D. G.; Sharma, A. K.; Mansour, T.; Witthuhn, B.; Perdigao, J.; Rudney, J. D.; Aparicio, C.; Gomez, A.

10.1101/2022.04.01.486588 — microbiology — Posted on 2022-04-01

3619 Frequency of change determines effectiveness of microbial response strategies in sulfidic stream microbiomes

Li, S.; Mosier, D.; Dong, X.; Kouris, A.; Ji, G.; Strous, M.; Diao, M.

10.1101/2022.04.01.486770 — microbiology — Posted on 2022-04-01

3620 Environment and the Evolutionary Trajectory of Horizontal Gene Transfer.

Bhatia, R. P.; Kirit, H. A.; Bollback, J. P.

10.1101/2022.04.01.486712 — microbiology — Posted on 2022-04-01

3621 Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

Planchais, C.; Fernandez, I.; Bruel, T.; Dias de Melo, G.; Prot, M.; Beretta, M.; Guardado-Calvo, P.; Dufloo, J.; Molinos-Albert, L. M.; Backovic, M.; Chiaravalli, J.; Giraud, E.; Vesin, B.; Conquet, L.; Grzelak, L.; Planas, D.; Staropoli, I.; Guivel-Benhassine, F.; Boulle, M.; Cervantes-Gonzalez, M.; French COVID Cohort Study Group, ; CORSER Study Group, ; Ungeheuer, M.-N.; Charneau, P.; van der Werf, S.; Agou, F.; Dimitrov, J. D.; Simon-Loriere, E.; Bourhy, H.; Montagutelli, X.; Rey, F. A.; Schwartz, O.; Mouquet, H.

10.1101/2022.04.01.486719 — immunology — Posted on 2022-04-01

3622 Recall of pre-existing cross-reactive B cell memory following Omicron breakthrough infection

Kaku, C. I.; Bergeron, A. J.; Ahlm, C.; Normark, J.; Sakharkar, M.; Forsell, M. N.; Walker, L. M.

10.1101/2022.04.01.486726 — immunology — Posted on 2022-04-01

3623 New broad-spectrum anti-Flavivirus human antibodies with Zika virus-neutralizing potential

de Oliveira Franca, R. K. A.; Silva, J. M.; Rodrigues, L. S.; Maranhao, A. Q.; Brigido, M. M.

10.1101/2022.04.01.486666 — immunology — Posted on 2022-04-01

3624 Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity

huang, s.; Jia, A.; Song, W.; Hessler, G.; Meng, Y.; Sun, Y.; Xu, L.; Laessle, H.; Jirschitzka, J.; Ma, S.; Xiao, Y.; Yu, D.; Hou, J.; Liu, R.; Sun, H.; Liu, X.; Han, Z.; Chang, J.; Parker, J. E.; Chai, J.

10.1101/2022.04.01.486681 — plant biology — Posted on 2022-04-01

3625 Decision Tree Ensembles Utilizing Multivariate Splits Are Effective at Investigating Beta-Diversity in Medically Relevant 16S Amplicon Sequencing Data

Rudar, J.; Golding, G. B.; Kremer, S. C.; Hajibabaei, M.

10.1101/2022.03.31.486647 — bioinformatics — Posted on 2022-04-01

3626 miRNA upregulate protein and glycan expression via direct activation in proliferating cells

Jame-Chenarboo, F.; Ng, H. H.; Macdonald, D.; Mahal, L. K.

10.1101/2022.04.01.486772 — biochemistry — Posted on 2022-04-01

3627 A single vesicle fluorescence-bleaching assay for multi-parameter analysis of proteoliposomes by total internal reflection fluorescence microscopy

Veit, S.; Paweletz, L. C.; Bohr, S. S.- R.; Menon, A. K.; Hatzakis, N. S.; Guenther Pomorski, T.

10.1101/2022.04.01.486744 — biochemistry — Posted on 2022-04-01

3628 In vivo prenylomic profiling in the brain of a transgenic mouse model of Alzheimer's disease reveals increased prenylation of a key set of proteins

Jeong, A.; Auger, S. A.; Maity, S.; Li, L.; Distefano, M. D.

10.1101/2022.04.01.486487 — biochemistry — Posted on 2022-04-01

3629 Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine

Cho, A.; Muecksch, F.; Wang, Z.; Ben Tanfous, T.; DaSilva, J.; Raspe, R.; Johnson, B.; Bednarski, E.; Ramos, V.; Schaefer-Babajew, D.; Shimeliovich, I.; Dizon, J.; Yao, K.-H.; Schmidt, F.; Millard, K. G.; Turroja, M.; Jankovic, M.; Oliveira, T. Y.; Gazumyan, A.; Gaebler, C.; Caskey, M.; Hatziioannou, T.; Bieniasz, P. D.; Nussenzweig, M. C.

10.1101/2022.03.31.486548 — immunology — Posted on 2022-04-01

3630 Beneficial and Detrimental Effects of Nonspecific Binding During DNA Hybridization

Phan, T. T. M.; Phan, T. M.; Schmit, J. D.

10.1101/2022.03.31.486645 — biophysics — Posted on 2022-04-01

3631 Size matters - the impact of nucleus size on results from spatial transcriptomics

Mohammadi, E.; Chojnowska, K.; Bienkowski, M.; Kostecka, A.; Koczkowska, M.; Zmijewski, M. A.; Jakalski, M.; Ingelsson, M.; Filipowicz, N.; Olszewski, P.; Davies, H.; Wierzbicka, J. M.; Hyman, B. T.; Dumanski, J. P.; Piotrowski, A.; Mieczkowski, J.

10.1101/2022.03.31.486657 — bioinformatics — Posted on 2022-04-01

3632 Drug combination prediction for cancer treatment using disease-specific drug response profiles and single-cell transcriptional signatures

Osorio, D.; Tekpli, X.; Kristensen, V. N.; Kuijjer, M. L.

10.1101/2022.03.31.486602 — bioinformatics — Posted on 2022-04-01

3633 De novo sequencing, diploid assembly, and annotation of the black carpenter ant, Camponotus pennsylvanicus, and its symbionts by one person for $1000, using nanopore sequencing.

Faulk, C.

10.1101/2022.03.31.486652 — genomics — Posted on 2022-04-01

3634 Direct and indirect impacts of positive selection on genomic variation in Drosophila serrata

Wang, Y.; Allen, S. L.; Reddiex, A. J.; Chenoweth, S.

10.1101/2022.03.31.486660 — genetics — Posted on 2022-04-01

3635 An Open and Continuously Updated Fern Tree of Life (FTOL)

Nitta, J.; Schuettpelz, E.; Ramirez Barahona, S.; Iwasaki, W.

10.1101/2022.03.31.486640 — evolutionary biology — Posted on 2022-04-01

3636 Irrational choices via a curvilinear representational geometry for value

Jurewicz, K.; Sleezer, B. J.; Mehta, P. S.; Hayden, B. Y.; Ebitz, R. B.

10.1101/2022.03.31.486635 — neuroscience — Posted on 2022-04-01

3637 Different olfactory neuron classes use distinct temporal and molecular programs to complete synaptic development

Aimino, M. A.; DePew, A. T.; Restrepo, L.; Mosca, T. J.

10.1101/2022.03.31.486637 — neuroscience — Posted on 2022-04-01

3638 Hippocampal CA1 represents action and reward events instantly compared to the superficial and deep layers of the lateral entorhinal cortex

Soma, S.; Ohara, S.; Nonomura, S.; Yoshida, J.; Suematsu, N.; Pastalkova, E.; Sakai, Y.; Tsutsui, K.-I.; Isomura, Y.

10.1101/2022.03.31.485431 — neuroscience — Posted on 2022-04-01

3639 History of previous midlife estradiol treatment permanently alters interactions of brain insulin-like growth factor-1 signaling and hippocampal estrogen synthesis to enhance cognitive aging in a rat model of menopause

Baumgartner, N. E.; McQuillen, S. M.; Perry, S. F.; Miller, S.; Gibbs, R.; Daniel, J. M.

10.1101/2022.03.31.486639 — neuroscience — Posted on 2022-04-01

3640 Informational Masking Can Constrain Acoustically Guided Mating Behavior

Gupta, S.; Bee, M. A.

10.1101/2022.03.31.486641 — neuroscience — Posted on 2022-04-01

3641 Prediction of brain functions from structural connectome using graph neural network

Hui, E. S.; Sun, Y.; Ko, H.; Chan, C. C. H.; Cao, P.

10.1101/2022.03.31.484925 — bioengineering — Posted on 2022-04-01

3642 PanGu Drug Model: Learn a Molecule Like a Human

Lin, X.; Xu, C.; Xiong, Z.; Zhang, X.; Ni, N.; Ni, B.; Chang, J.; Pan, R.; Wang, Z.; Yu, F.; Jiang, H.; Zheng, M.; Qiao, N.

10.1101/2022.03.31.485886 — biochemistry — Posted on 2022-04-01

3643 Cell type-specific Expression Quantitative Trait Loci

Little, P.; Zhabotynsky, V.; Li, Y.; Lin, D.; Sun, W.

10.1101/2022.03.31.486605 — genomics — Posted on 2022-04-01

3644 An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines

Seifert, S. N.; Bai, S.; Fawcett, S.; Norton, E. B.; Zwezdaryk, K. J.; Robinson, J.; Gunn, B.; Letko, M. C.

10.1101/2021.12.05.471310 — microbiology — Posted on 2022-04-01

3645 Development of a long-read NGS workflow for improved characterization of fastidious respiratory mycoplasmas

Framst, I.; D`Andrea, C.; Baquero, M. M.; Maboni, G.

10.1101/2022.03.31.486658 — microbiology — Posted on 2022-04-01

3646 Rapid and accurate identification of Escherichia coli STEC O157:H7 by mass spectrometry, artificial intelligence and detection of specific biomarkers peaks.

Manfredi, E.; Rocca, F.; Zintgraff, J.; Irazu, L.; Miliwebsky, E.; Carbonari, C.; Deza, N.; Prieto, M.; Chinen, I.

10.1101/2022.03.31.486435 — microbiology — Posted on 2022-04-01

3647 MAIT cells activate dendritic cells to promote T follicular helper cell differentiation and humoral immunity

Pankhurst, T. E.; Buick, K. H.; Lange, J. L.; Marshall, A. J.; Button, K. R.; Palmer, O. R.; Farrand, K. J.; Stewart, I. F. N.; Bird, T.; Mason, N. C.; Compton, B. J.; Comoletti, D.; Salio, M.; Painter, G. F.; Hermans, I. F.; Connor, L. M.

10.1101/2022.03.31.486638 — immunology — Posted on 2022-04-01

3648 Follicular helper T cells expressing Blimp1 are specialized for plasma cell differentiation

Miller, K. B.; Suparski, A. G.; Higgins, B. W.; Sharma, S. M.; Milpied, P. J.; McHeyzer-Williams, L. J.; McHeyzer-Williams, M. G.

10.1101/2022.03.31.486642 — immunology — Posted on 2022-04-01

3649 The mouse claustrum synaptically connects cortical network motifs

Qadir, H.; Stewart, B. W.; Van Ryzin, J.; Wu, Q.; Chen, S.; Seminowicz, D. A.; Mathur, B. N.

10.1101/2022.03.31.486634 — neuroscience — Posted on 2022-04-01

3650 GPR183 mediates the capacity of the novel CD47-CD19 bispecific antibody TG-1801 to heighten ublituximab-umbralisib (U2) anti-lymphoma activity

Ribeiro, M.; Profitos-Peleja, N.; Santos, J. C.; Blecua, P.; Reyes Garau, D.; Armengol, M.; Fernandez-Serrano, M.; Miskin, H. P.; Bosch, F.; Esteller, M.; Normant, E.; Roue, G.

10.1101/2022.03.31.486558 — cancer biology — Posted on 2022-04-01

3651 Targeted Proteomics and Support Vector Classification Reveal Potential Biomarkers for the Early Detection of High-grade Serous Ovarian Cancer

Cooper, T. T.; Dieters-Castator, D. Z.; Liu, J.; Siegers, G. M.; Pink, D.; Lewis, J. D.; Fu, Y.; Steed, H.; Lajoie, G. A.; Postovit, L. M.

10.1101/2022.03.31.486596 — cancer biology — Posted on 2022-04-01

3652 Active Anemosensing Hypothesis: How Flying Insects Could Estimate Ambient Wind Direction Through Sensory Integration & Active Movement

van Breugel, F.; Jewell, R.; Houle, J.

10.1101/2022.03.31.486300 — animal behavior and cognition — Posted on 2022-04-01

3653 Multi-environment genome-wide association mapping of culm morphology traits in barley

Bretani, G.; Shaaf, S.; Tondelli, A.; Cattivelli, L.; Delbono, S.; Waugh, R.; Thomas, W. T. B.; Russel, J.; Bull, H.; Igartua, E.; Casas, A. M.; Gracia, P.; Rossi, R.; Schulman, A. H.; Rossini, L.

10.1101/2022.03.30.486427 — plant biology — Posted on 2022-04-01

3654 BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair

Jimenez-Sainz, J.; Mathew, J.; Moore, G.; Lahiri, S.; Garbarino, J.; Eder, J. P.; Rothenberg, E.; Jensen, R. B.

10.1101/2021.09.24.461749 — cancer biology — Posted on 2022-04-01

3655 Temporal and Spatial Resolution of a Protein Quake that Activates Hydrogen Tunneling in Soybean Lipoxygenase

Zaragoza, J. P.; Offenbacher, A. R.; Hu, S.; Gee, C. L.; Firestein, Z. M.; Minnetian, N.; Deng, Z.; Fan, F.; Iavarone, A. T.; Klinman, J. P.

10.1101/2022.03.31.486235 — biophysics — Posted on 2022-04-01

3656 Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle

D'Ercole, C.; D'Angelo, P.; Ruggieri, V.; Proietti, D.; Sanchez Riera, C.; Macone, A.; Bonvissuto, D.; Sette, C.; Giordani, L.; Madaro, L.

10.1101/2022.03.31.486563 — molecular biology — Posted on 2022-04-01

3657 Munc13 supports vesicle fusogenicity after disrupting active zone scaffolds and synaptic vesicle docking

Tan, C.; de Nola, G.; Qiao, C.; Imig, C.; Brose, N.; Kaeser, P. S.

10.1101/2022.04.01.486686 — neuroscience — Posted on 2022-04-01

3658 A neural decision signal during internal sampling from working memory

van Ede, F.; Nobre, A. C.

10.1101/2022.03.31.486618 — neuroscience — Posted on 2022-04-01

3659 Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics electrophysiological phenotype of the A53T mutation

Hornauer, P.; Prack, G.; Anastasia, N.; Ronchi, S.; Kim, T.; Donner, C.; Fiscella, M.; Borgwardt, K.; Taylor, V.; Jagasia, R.; Roqueiro, D.; Hierlemann, A.; Schroeter, M.

10.1101/2022.03.31.486582 — neuroscience — Posted on 2022-04-01

3660 Impact of 98 LRRK2 variants linked to Parkinson's Disease on kinase activity and microtubule binding

Kalogeropulou, A. F.; Purlyte, E.; Tonelli, F.; Lange, S. M.; Wightman, M.; Prescott, A. R.; Padmanabhan, S.; Sammler, E.; Alessi, D. R.

10.1101/2022.04.01.486724 — neuroscience — Posted on 2022-04-01

3661 Long-range inhibition synchronizes and updates prefrontal task activity

Cho, K.; Shi, J.; Sohal, V. S.

10.1101/2022.03.31.486626 — neuroscience — Posted on 2022-04-01

3662 Relative stability of mRNA and protein severely limits inference of gene networks from single-cell mRNA measurements

Mahajan, T.; Saint-Antoine, M.; Dar, R. D.; Singh, A.

10.1101/2022.03.31.486623 — systems biology — Posted on 2022-04-01

3663 Characterization of EDS1-independent plant defense responses against bacterial pathogens using Duckweed/Pseudomonas pathosystems

Baggs, E. L.; Tiersma, M. B.; Abramsom, B. W.; Michael, T.; Krasileva, K. V.

10.1101/2022.03.31.486129 — plant biology — Posted on 2022-04-01

3664 Effect of tempol on post-thaw semen parameters and fertility during chicken semen cryopreservation

Murugesan, S.; Mahapatra, R. K.

10.1101/2022.03.31.486544 — physiology — Posted on 2022-04-01

3665 Influence of ambient day light variations and age on the Iris-pupillary area ratio in beef cattle

Chojnacka, P.; Kumar, A.

10.1101/2022.03.31.486575 — physiology — Posted on 2022-04-01

3666 Mass red blood cell extravasation and tubular uptake results in toxic injury to the tubules during kidney ischemia from venous clamping

McLarnon, S. R.; Johnson, C.; Sun, J.; O'Herron, P.; Marshall, B.; Barrett, A.; O'Connor, P. M.

10.1101/2022.03.31.486613 — physiology — Posted on 2022-04-01

3667 An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant

Thomas, S. P.; Gauglitz, J. M.; Tripathi, A.; Vargas, F.; Bertrand, K.; Chambers, C. D.; Kim, J. H.; Dorrestein, P. C.; Tsunoda, S. M.

10.1101/2022.03.31.486633 — pharmacology and toxicology — Posted on 2022-04-01

3668 Shedding Light on the Black Box of a Neural Network Used to Detect Prostate Cancer in Whole Slide Images by Occlusion-Based Explainability

Krajnansky, V.; Gallo, M.; Nenutil, R.; Nemecek, M.; Holub, P.; Brazdil, T.

10.1101/2022.03.31.486599 — pathology — Posted on 2022-04-01

3669 RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancer

Li, Z.; Sun, J.; Rahman, N.; Yan, B.; Utturkar, S.; Lanman, N. A.; Kazemian, M.; Caron de Fromentel, C.; Levrero, M.; Andrisani, O.

10.1101/2022.03.31.486452 — cancer biology — Posted on 2022-04-01

3670 Phasor-Based Multi-Harmonic Unmixing for in-vivo Hyperspectral Imaging

Vallmitjana, A.; Lepanto, P.; Irigoin, F.; Malacrida, L. S.

10.1101/2022.03.31.486485 — biophysics — Posted on 2022-04-01

3671 ShrinkCRISPR : A flexible method for differential fitness analysis of CRISPR-Cas9 screen data.

Tissier, R.; van Schie, J. J. M.; Wolthuis, R. M. F.; de Lange, j.; de Menezes, R. X.

10.1101/2022.03.31.486584 — bioinformatics — Posted on 2022-04-01

3672 StORF-Reporter: Finding Genes between Genes

Dimonaco, N. J.; Aubrey, W.; Kenobi, K.; Clare, A.; Creevey, C. J.

10.1101/2022.03.31.486628 — bioinformatics — Posted on 2022-04-01

3673 Full-mouth photoacoustic/ultrasound imaging of the periodontal pocket with a compact intraoral transducer

Fu, L.; Khazaeinezhad, R.; Hariri, A.; Qi, B.; Chen, C.; Jokerst, J. V.

10.1101/2022.03.31.486608 — bioengineering — Posted on 2022-04-01

3674 Imaging optically thick tissues simply and reproducibly: a practical guide to Lightsheet Macroscopy

Williams, R. M.; Bloom, J. C.; Robertus, C.; Recknagel, A. K.; Putnam, D.; Schimenti, J. C.; Zipfel, W.

10.1101/2022.03.31.486601 — bioengineering — Posted on 2022-04-01

3675 Quantitative crosslinking and mass spectrometry determine binding interfaces and affinities mediating kinetochore stabilization

Hagemann, G.; Solis-Mezarino, V.; Singh, S.; Potocnjak, M.; Kumar, C.; Herzog, F.

10.1101/2022.03.31.486303 — biochemistry — Posted on 2022-04-01

3676 String-Pulling as a Behavioral Assessment of Skilled Forelimb Motor Function in a Middle Cerebral Artery Occlusion Rat Model

Hart, M.; Blackwell, A. A.; Whishaw, I. Q.; Wallace, D. G.; Cheatwood, J. L.

10.1101/2022.03.31.486586 — animal behavior and cognition — Posted on 2022-04-01

3677 Identification of large offspring syndrome during pregnancy through ultrasonography and maternal blood transcriptome analyses

Rivera, R. M.; Goldkamp, A. K.; Patel, B. N.; Hagen, D. E.; Soto-Moreno, E. J.; Li, Y.; Kim, C. N.; Miller, C.; Williams, F.; Jannaman, E.; Xiao, Y.; Tribulo, P.; Estrada-Cortes, E.; Brau-Rodriguez, A. R.; Hansen, P. J.; Wu, Z.; Spinka, C. M.; Martin, N.; Elsik, C. G.

10.1101/2022.03.31.486611 — developmental biology — Posted on 2022-04-01

3678 Endo-lysosomal assembly variations among Human Leukocyte Antigen class I (HLA-I) allotypes

Olson, E.; Ceccarelli, T.; Raghavan, M.

10.1101/2022.03.31.485520 — immunology — Posted on 2022-04-01

3679 Normative sleep spindle database and findings from 772 healthy children from birth through 18 years

Kwon, H.; Walsh, K. G.; Berja, E. D.; Manoach, D. S.; Eden, U. T.; Kramer, M. A.; Chu, C. J.

10.1101/2022.03.31.486476 — neuroscience — Posted on 2022-04-01

3680 The role of capacity constraints in Convolutional Neural Networks for learning random versus natural data

Tsvetkov, C.; Malhotra, G.; Evans, B. D.; Bowers, J. S.

10.1101/2022.03.31.486580 — neuroscience — Posted on 2022-04-01

3681 EEG-representational geometries and psychometric distortions in approximate numerical judgment

Appelhoff, S.; Hertwig, R.; Spitzer, B.

10.1101/2022.03.31.486560 — neuroscience — Posted on 2022-04-01

3682 Performance comparison of systemic activity correction in fNIRS for methods with and without short distance channels

Klein, F.; Luehrs, M.; Benitez-Andonegui, A.; Roehn, P.; Kranczioch, C.

10.1101/2022.03.31.486522 — neuroscience — Posted on 2022-04-01

3683 Unraveling the functional attributes of the language connectome: crucial subnetworks, flexibility and variability.

Roger, E.; Rodrigues de Almeida, L.; Loevenbruck, H.; Perrone-Bertolotti, M.; Cousin, E.; Schwartz, J.-L.; Perrier, P.; Dohen, M.; Vilain, A.; Baraduc, P.; Achard, S.; Baciu, M.

10.1101/2022.03.31.486594 — neuroscience — Posted on 2022-04-01

3684 Affective enhancement of episodic memory is associated with widespread patterns of intrinsic functional connectivity across the adult lifespan

Katsumi, Y.; Moore, M.

10.1101/2022.03.31.485630 — neuroscience — Posted on 2022-04-01

3685 Frontal Cortex Gates Distractor Stimulus Encoding in Target Sensory Cortex

Zhang, Z.; Zagha, E.

10.1101/2022.03.31.486430 — neuroscience — Posted on 2022-04-01

3686 Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

Yamano, S.; Goto, Y.; Takeda, T.; Hirai, S.; Furukawa, Y.; Kikuchi, Y.; Kasai, T.; Misumi, K.; Suzuki, M.; Takanobu, K.; Senoh, H.; Saito, M.; Kondo, H.; Umeda, Y.

10.1101/2022.03.31.486525 — pathology — Posted on 2022-04-01

3687 Transcriptional landscape in BRAF wild type metastatic melanoma

Lastraioli, E.; Ruffinatti, F. A.; di Costanzo, F.; Munaron, L.; Arcangeli, A.

10.1101/2022.03.31.486532 — cancer biology — Posted on 2022-04-01

3688 Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T cell lymphoma

Vanden Bempt, M.; Debackere, K.; Demeyer, S.; Van Thillo, Q.; Meeuws, N.; Provost, S.; Mentens, N.; Jacobs, K.; Gielen, O.; Nittner, D.; Ogawa, S.; Kataoka, K.; Graux, C.; Tousseyn, T.; Cools, J.; Dierickx, D.

10.1101/2022.03.31.486583 — cancer biology — Posted on 2022-04-01

3689 Bladder cancer organoids as a functional system to model different disease stages and therapy response

Minoli, M.; Cantore, T.; Kiener, M.; Fedrizzi, T.; La Manna, F.; Karkampouna, S.; Genitisch, V.; Rodriguez, A.; Klima, I.; Gasperini, P.; Kiss, B.; Seiler-Blarer, R.; Demichelis, F.; Thalmann, G. N.; Kruithof-de Julio, M.

10.1101/2022.03.31.486514 — cancer biology — Posted on 2022-04-01

3690 Does Tesla valve work for microscale active swimmers? - a computational study

Rogers, A. T.; Wang, Y.

10.1101/2022.03.31.486569 — biophysics — Posted on 2022-04-01

3691 Small molecules from Bacopa monneiri as potent inhibitors against Neurodegenerative disorders

Sangeet, S.; Khan, A.

10.1101/2022.03.31.486590 — bioinformatics — Posted on 2022-04-01

3692 A Novel Sequence Labeling Framework for Extracting Drug-Protein Relations from Biomedical Literature

Luo, L.; Lai, P.-T.; Wei, C.-H.; Lu, Z.

10.1101/2022.03.31.486574 — bioinformatics — Posted on 2022-04-01

3693 Designing microplate layouts using artificial intelligence

Francisco Rodriguez, M. A.; Carreras-Puigvert, J.; Spjuth, O.

10.1101/2022.03.31.486595 — bioinformatics — Posted on 2022-04-01

3694 RNAinsecta: A tool for prediction of pre-microRNA in insects using machine learning algorithms.

Nath, A.; Bora, U.

10.1101/2022.03.31.486617 — bioinformatics — Posted on 2022-04-01

3695 Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and Interfaces

Peng, L.; Matellan, C.; del Rio Hernandez, A.; Gautrot, J. E.

10.1101/2022.03.31.485540 — bioengineering — Posted on 2022-04-01

3696 Human iPSC-Vascular Smooth Muscle Cell Spheroids Demonstrate Size-dependent Alterations in Cellular Viability and Secretory Function

Islam, S.; Parker, J.; Dash, B. C.; Hsia, H.

10.1101/2022.03.31.486610 — bioengineering — Posted on 2022-04-01

3697 Characterization of a miniaturized ultrasound transducer customized for oral health applications

Qi, B.; Hariri, A.; Khazaeinezhad, R.; Fu, L.; Jokerst, J. V.

10.1101/2022.03.31.486598 — bioengineering — Posted on 2022-04-01

3698 A robust method for measuring social reward in adult mice

Harda, Z.; Chroszcz, M.; Misiołek, K.; Klimczak, M.; Szumiec, Łukasz; Kaczmarczyk-Jarosz, M.; Rodriguez Parkitna, J.

10.1101/2022.03.31.486566 — animal behavior and cognition — Posted on 2022-04-01

3699 Improved Centromere Assemblies for RefGen_v4

Laspisa, D. J.; Schneider, K. L.; Presting, G. G.

10.1101/2022.03.30.486462 — genomics — Posted on 2022-04-01

3700 dartR v2: an accessible genetic analysis platform for conservation, ecology, and agriculture

Mijangos, J. L.; Gruber, B.; Berry, O.; Pacioni, C.; Georges, A.

10.1101/2022.03.30.486475 — genomics — Posted on 2022-04-01

3701 Robust inference of expression state in bulk and single-cell RNA-Seq using curated intergenic regions

Fonseca Costa, S. S.; Rosikiewicz, M.; Roux, J.; Wollbrett, J.; Bastian, F. B.; Robinson-Rechavi, M.

10.1101/2022.03.31.486555 — genomics — Posted on 2022-04-01

3702 OTTERS: A powerful TWAS framework leveraging summary-level reference data

Dai, Q.; Zhou, G.; Zhao, H.; Vosa, U.; Franke, L.; Battle, A.; Teumer, A.; Lehtimaki, T.; Raitakari, O.; Esko, T.; eQTLGen Consortium, ; Epstein, M. P.; Yang, J.

10.1101/2022.03.30.486451 — genetics — Posted on 2022-04-01

3703 Cas9 targeted nanopore sequencing with enhanced variant calling improves CYP2D6-CYP2D7 hybrid allele genotyping

Rubben, K.; Tilleman, L.; Deserranno, K.; Tytgat, O.; Deforce, D.; Van Nieuwerburgh, F.

10.1101/2022.03.31.486504 — genetics — Posted on 2022-04-01

3704 Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors

Kang, M.; Na, H. Y.; Kim, J.-W.; Ahn, S.; Lee, S.; Ahn, S.; Lee, J. H.; Youk, J.; Kim, H. T.; Kim, K.-J.; Suh, K. J.; Lee, J. S.; Kim, S. H.; Kim, J. W.; Kim, Y. J.; Lee, K.-W.; Yoon, Y.-S.; Kim, J. H.; Chung, J.-H.; Han, H.-S.; Lee, J. S.

10.1101/2022.03.31.486530 — genetics — Posted on 2022-04-01

3705 The genome sequence of the scarce swallowtail, Iphiclides podalirius

Mackintosh, A.; Laetsch, D. R.; Baril, T.; Ebdon, S.; Jay, P.; Vila, R.; Hayward, A.; Lohse, K.

10.1101/2022.03.31.486480 — evolutionary biology — Posted on 2022-04-01

3706 The genetic architecture of multiple mutualisms and mating system in Turnera ulmifolia

Laurich, J. R.; Reid, C. G.; Biel, C.; Wu, T.; Knox, C.; Frederickson, M. E.

10.1101/2022.03.31.484762 — evolutionary biology — Posted on 2022-04-01

3707 Predicting catchment suitability for biodiversity at national scales

Dobson, B.; Barry, S.; Maes-Prior, R.; Mijic, A.; Woodward, G.; Pearse, W. D.

10.1101/2022.03.31.486513 — ecology — Posted on 2022-04-01

3708 High predation risk decimates survival duringthe reproduction season

Smolinsky, R.; Hiadlovska, Z.; Marsala, S.; Skrabanek, P.; Skrobanek, M.; Martinkova, N.

10.1101/2022.03.31.486539 — ecology — Posted on 2022-04-01

3709 Autophagy slows the aging of Germline stem cells in Drosophila through modulation of E-cadherin

Shravage, B. V.; Murmu, N.

10.1101/2022.03.31.486570 — developmental biology — Posted on 2022-04-01

3710 Medial prefrontal-hippocampal concordance in child-parent dyads underlies children's psychological wellbeing

Su, H.; Young, C. B.; Han, Z. R.; Xu, J.; Xiong, B.; Wang, J.; Hao, L.; Yang, Z.; Chen, G.; Qin, S.

10.1101/2022.03.30.486310 — neuroscience — Posted on 2022-04-01

3711 CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder

Tamura, S.; Nelson, A. D.; Spratt, P. W.; Kyoung, H.; Zhou, X.; Li, Z.; Zhao, J.; Holden, S. S.; Sahagun, A.; Keeshen, C. M.; Lu, C.; Hamada, E. C.; Ben-Shalom, R.; Pan, J. Q.; Paz, J. T.; Sanders, S. J.; Matharu, N.; Ahituv, N.; Bender, K. J.

10.1101/2022.03.30.486483 — neuroscience — Posted on 2022-04-01

3712 Responses of cortical neurons to intracortical microstimulation in awake primates

Yun, R.; Mishler, J.; Perlmutter, S. I.; Rao, R. P. N.; Fetz, E. E.

10.1101/2022.03.30.486457 — neuroscience — Posted on 2022-04-01

3713 Retinal ganglion cell endowment is correlated with optic tract fiber cross section, not density

Taskin, H. O.; Qiao, Y.; Sydnor, V. J.; Cieslak, M.; Haggerty, E. B.; Satterthwaite, T. D.; Morgan, J. I.; Shi, Y.; Aguirre, G. K.

10.1101/2022.03.30.486288 — neuroscience — Posted on 2022-04-01

3714 Different patterns of visual processing for shapes in V1 of mouse and monkey

Ben Yehoshua, E.; Slovin, H.

10.1101/2022.03.31.486346 — neuroscience — Posted on 2022-04-01

3715 The role of clearance in neurodegenerative diseases

Brennan, G. S.; Thompson, T. B.; Oliveri, H.; Rognes, M. E.; Goriely, A.

10.1101/2022.03.31.486533 — neuroscience — Posted on 2022-04-01

3716 The impact of sparsity in low-rank recurrent neural networks

Herbert, E.; Ostojic, S.

10.1101/2022.03.31.486515 — neuroscience — Posted on 2022-04-01

3717 A fluctuation-based approach to infer kinetics and topology of cell-state switching

Saint-Antoine, M. M.; Grima, R.; Singh, A.

10.1101/2022.03.30.486492 — systems biology — Posted on 2022-04-01

3718 Padé SSA: A frequency domain method for estimating the dynamics of stochastic reaction networks

Gupta, A.; Khammash, M.

10.1101/2022.03.31.486511 — systems biology — Posted on 2022-04-01

3719 Defining Predictors of Successful Early Career to Independent Funding Conversion Among Surgeon-Scientists

Keswani, S. S.; Short, W. D.; Mehl, S. C.; Singampalli, K. L.; Parikh, U. M.; Potturu, M.; Masri, L.; Olutoye, O. O.; Cheng, L. S.; King, A.; Lee, T. C.

10.1101/2022.03.30.486442 — scientific communication and education — Posted on 2022-04-01

3720 Discussion-based DEI education to help create inclusive and open BME research lab environments

Naiknavare, R.; Maisel, K.

10.1101/2022.03.30.486429 — scientific communication and education — Posted on 2022-04-01

3721 Dissecting Succulence: Crassulacean Acid Metabolism and Hydraulic Capacitance are Independent Adaptations in Clusia Leaves

Leverett, A.; Hartzell, S.; Winter, K.; Garcia, M.; Aranda, J.; Virgo, A.; Smith, A. J.; Focht, P.; Rasmussen-Arda, A.; Willats, W. G. T.; Cowan-Turner, D.; Borland, A. M.

10.1101/2022.03.30.486278 — plant biology — Posted on 2022-04-01

3722 Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition

Snoeck, S.; Abramson, B. W.; Garcia, A. G. K.; Egan, A. N.; Michael, T. P.; Steinbrenner, A. D.

10.1101/2022.03.30.484633 — plant biology — Posted on 2022-04-01

3723 Multi-omic profiling of the leukemic microenvironment shows bone marrow interstitial fluid is distinct from peripheral blood plasma

Nierves, L.; Guo, J.; Chen, S.; Tsui, J.; Uzozie, A. C.; Bush, J. W.; Huan, T.; Lange, P. F.

10.1101/2022.03.30.486272 — cancer biology — Posted on 2022-04-01

3724 Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

Sipe, L. M.; Chaib, M.; Korba, E. B.; Lovely, M. C.; Jo, H.; Counts, B. R.; Tanveer, U.; Clements, J. C.; John, N. A.; Daria, D.; Marion, T. N.; Sekhri, R.; Pingili, A. K.; Teng, B.; Carson, J. A.; Hayes, D. N.; Davis, M. J.; Pierre, J. F.; Makowski, L.

10.1101/2022.03.30.486293 — cancer biology — Posted on 2022-04-01

3725 The dynamical Matryoshka model: 3. Diffusive nature of the atomic motions contained in a new dynamical model for deciphering local lipid dynamics

Matsuo, T.; Cisse, A.; Plazanet, M.; Natali, F.; Marek Koza, M.; Olivier, J.; Bicout, D.; Peters, J.

10.1101/2022.03.30.486412 — biophysics — Posted on 2022-04-01

3726 An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequences

Gurun, B.; Horton, W.; Murugan, D.; Zhu, B.; Leyshock, P.; Kumar, S.; Byrne, K. T.; Vonderheide, R. H.; Margolin, A. A.; Mori, M.; Spellman, P. T.; Coussens, L. M.; Speed, T. P.

10.1101/2022.03.30.486449 — bioinformatics — Posted on 2022-04-01

3727 Improved performance of biohybrid muscle-based bio-bots doped with piezoelectric boron nitride nanotubes

Mestre, R.; Fuentes, J.; Lefaix, L.; Wang, J.; Guix, M.; Murillo, G.; Bashir, R.; Sanchez, S.

10.1101/2022.03.30.486204 — bioengineering — Posted on 2022-04-01

3728 Felidae call type and species identification based on acoustic features

Bandara, D.; Exantus, K.; Navarro-Martinez, C.; Patterson, M.; Byun, A.

10.1101/2022.03.30.486147 — animal behavior and cognition — Posted on 2022-04-01

3729 Insights into the domestication of avocado and potential genetic contributors to heterodichogamy

Solares, E. A.; Morales-Cruz, A.; Figueroa Balderas, R.; Focht, E.; Ashworth, V. E. T. M.; Wyant, S. R.; Minio, A.; Cantu, D.; Arpaia, M. L.; Gaut, B. S.

10.1101/2022.03.30.486474 — genomics — Posted on 2022-04-01

3730 Macroevolutionary diversity of traits and genomes in the model yeast genus Saccharomyces

Peris, D.; Ubbelohde, E. J.; Kuang, M. C.; Kominek, J.; Langdon, Q. K.; Adams, M.; Koshalek, J. A.; Hulfachor, A. B.; Opulente, D. A.; Hall, D. J.; Hyma, K.; Fay, J. C.; Leducq, J.-B.; Charron, G.; Landry, C. R.; Libkind, D.; Goncalves, C.; Goncalves, P.; Sampaio, J. P.; Wang, Q.-M.; Bai, F.-Y.; Wrobel, R. L.; Hittinger, C. T.

10.1101/2022.03.30.486421 — evolutionary biology — Posted on 2022-04-01

3731 Fold Evolution by Creative Destruction

Alvarez-Carreno, C.; Gupta, R. J.; Petrov, A. S.; Williams, L. D.

10.1101/2022.03.30.486258 — evolutionary biology — Posted on 2022-04-01

3732 Convergent genomic signatures of adaptation to an extreme environment in cyprinoid fishes

Tong, C.; Li, M.

10.1101/2022.03.30.486405 — evolutionary biology — Posted on 2022-04-01

3733 Evolutionary relationships and range evolution of greenhood orchids (subtribe Pterostylidinae): insights from plastid phylogenomics

Nargar, K.; O'Hara, K.; Mertin, A.; Bent, S.; Nauheimer, L.; Simpson, L.; Zimmer, H.; Molloy, B. P. J.; Clements, M. A.

10.1101/2022.03.30.486312 — evolutionary biology — Posted on 2022-04-01

3734 Climate adaptation and vulnerability of foundation species in a global change hotspot

Gallegos, C.; Hodgins, K. A.; Monro, K.

10.1101/2022.03.30.486132 — evolutionary biology — Posted on 2022-04-01

3735 Introduced crops supplement rather than replace indigenous crops in an African center of agrobiodiversity

Rampersad, C.; Geto, T.; Samuel, T.; Abebe, M.; Soto Gomez, M.; Pironon, S.; Buchi, L.; Haggar, J.; Stocks, J.; Ryan, P.; Buggs, R. J. A.; Demissew, S.; Wilkin, P.; Borrell, J. S.

10.1101/2022.03.30.486402 — ecology — Posted on 2022-04-01

3736 The interplay between habitat fragmentation and life traits affects specialization in lichen symbioses

Berlinches de Gea, A.; Perez-Ortega, S.; Verdu, M.; Villar-dePablo, M.

10.1101/2022.03.30.485788 — ecology — Posted on 2022-04-01

3737 Lethal and sub-lethal concentrations of pesticides detected in milkweeds purchased from nurseries across the United States

Halsch, C. A.; Hoyle, S. M.; Code, A.; Fordyce, J. A.; Forister, M. L.

10.1101/2022.03.30.486459 — ecology — Posted on 2022-04-01

3738 The cardiopharyngeal mesoderm contributes to lymphatic vessel development

Maruyama, K.; Miyagawa-Tomita, S.; Haneda, Y.; Kida, M.; Matsuzaki, F.; Imanaka-Yoshida, K.; Kurihara, H.

10.1101/2022.03.30.486479 — developmental biology — Posted on 2022-04-01

3739 Evaluating impact of experimental design on accuracy of parameter estimation and model selection efficiency: T cell clustering as a case study

Rajakaruna, H.; Ganusov, V. V.

10.1101/2022.03.30.486434 — immunology — Posted on 2022-04-01

3740 Integrated single-cell (phospho-)protein and RNA detection uncovers phenotypic characteristics of human antibody secreting cells.

van Buijtenen, E.; Janssen, W.; Vink, P.; Habraken, M. J. M.; Wingens, L. J. A.; van Elsas, A.; Huck, W. T. S.; van Buggenum, J. A. G. L.; van Eenennaam, H.

10.1101/2022.03.31.486501 — immunology — Posted on 2022-04-01

3741 Unraveling axonal mechanisms of traumatic brain injury

Devoto, V. M. P.; Lacovich, V.; Feole, M.; Bhat, P.; Chovan, J.; Carna, M.; Onyango, I. G.; Dragisic, N.; Susserova, M.; Barrios-Llerena, M. E.; Stokin, G. B.

10.1101/2022.03.30.486433 — neuroscience — Posted on 2022-04-01

3742 High-contrast en-bloc staining of mouse whole-brain samples for EM-based connectomics

Song, K.; Feng, Z.; Helmstaedter, M.

10.1101/2022.03.30.486341 — neuroscience — Posted on 2022-04-01

3743 Computational analysis of memory consolidation following inhibitory avoidance (IA) training in adult and infant rats: critical roles of CaMKIIα and MeCP2

Zhang, Y.; Smolen, P. D.; Alberini, C.; Baxter, D. A.; Byrne, J.

10.1101/2022.03.30.486426 — neuroscience — Posted on 2022-04-01

3744 A recurrent network architecture explains tectal activity dynamics and experience-dependent behaviour

Zylbertal, A.; Bianco, I. H.

10.1101/2022.03.30.486335 — neuroscience — Posted on 2022-04-01

3745 Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells

Mäki-Marttunen, T.; Mäki-Marttunen, V.

10.1101/2022.03.30.486368 — neuroscience — Posted on 2022-04-01

3746 Electrophysiological signatures reveal spinal learning mechanisms for a lasting sensorimotor adaptation

Lavaud, S.; D'Andola, M.; Bichara, C.; Takeoka, A.

10.1101/2022.03.30.486422 — neuroscience — Posted on 2022-04-01

3747 A neuromodulatory model for determining the effect of emotion-respiration-cognition coupling on the time-to-respond

Yonekura, S.; Cueto, J.; Kanazawa, H.; Atsumi, N.; Hirabayashi, S.; Iwamoto, M.; Kuniyoshi, Y.

10.1101/2022.03.30.486453 — neuroscience — Posted on 2022-04-01

3748 Hand-foot coordination is significantly influenced by motion direction in individuals with autism spectrum disorder

Umesawa, Y.; Matsushima, K.; Fukatsu, R.; Terao, Y.; Ide, M.

10.1101/2022.03.30.486494 — neuroscience — Posted on 2022-04-01

3749 Studies of a siderophore-producing cyclization domain: A refined proposal of substrate binding

Gnann, A. D.; Xia, Y.; Soule, J.; Barthelemy, C.; Mawani, J. S.; Nzikoba Musoke, S.; Castellano, B. M.; Brignole, E. J.; Frueh, D.; Dowling, D. P.

10.1101/2022.03.18.483834 — biochemistry — Posted on 2022-04-01

3750 Experimental demonstration of tethered gene drive systems for confined population modification or suppression

Metzloff, M.; Yang, E.; Dhole, S.; Clark, A. G.; Messer, P. W.; Champer, J.

10.1101/2021.05.29.446308 — genetics — Posted on 2022-04-01

3751 Novel Methods for Multi-ancestry Polygenic Prediction and their Evaluations in 3.7 Million Individuals of Diverse Ancestry

Zhang, H.; Zhan, J.; Jin, J.; Ahearn, T. U.; Yu, Z.; O'Connell, J.; Jiang, Y.; Chen, T.; 23andMe Research Team, ; Garcia-Closas, M.; Lin, X.; Koelsch, B. L.; Chatterjee, N.

10.1101/2022.03.24.485519 — genetics — Posted on 2022-04-01

3752 Competitive evolution of H1N1 and H3N2 influenza viruses in the United States: A mathematical modeling study

Wilasang, C.; Suttirat, P.; Wiratsudakul, A.; Chadsuthi, S.; Modchang, C.

10.1101/2021.09.30.462654 — evolutionary biology — Posted on 2022-04-01

3753 Competition contributes to both warm and cool range edges

Lyu, S.; Alexander, J. M.

10.1101/2022.02.20.481210 — ecology — Posted on 2022-04-01

3754 In-depth characterization of denitrifier communities across different soil ecosystems in the tundra

Pessi, I. S.; Viitamaki, S.; Virkkala, A.-M.; Eronen-Rasimus, E.; Delmont, T. O.; Marushchak, M. E.; Luoto, M.; Hultman, J.

10.1101/2020.12.21.419267 — microbiology — Posted on 2022-04-01

3755 Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions

Pringle, E. S.; Duguay, B. A.; Bui-Marinos, M. P.; Mulloy, R. P.; Landreth, S. L.; Desireddy, K. S.; Dolliver, S. M.; Ying, S.; Caddell, T.; Slaine, P. D.; Bearne, S. L.; Falzarano, D.; Corcoran, J.; Khaperskyy, D. A.; McCormick, C.

10.1101/2022.03.10.483772 — microbiology — Posted on 2022-04-01

3756 Inflammasome activation in infected macrophages drives COVID-19 pathology

Sefik, E.; Qu, R.; Junqueira, C.; Kaffe, E.; Mirza, H.; Zhao, J.; Brewer, J. R.; Han, A.; Steach, H. R.; Israelow, B.; Blackburn, H. N.; Velazquez, S.; Chen, Y. G.; Halene, S.; Iwasaki, A.; Meffre, E.; Nussenzweig, M.; Lieberman, J.; Wilen, C. B.; Kluger, Y.; Flavell, R. A.

10.1101/2021.09.27.461948 — immunology — Posted on 2022-04-01

3757 Omicron BA.1 and BA.2 Variants Increase the Interactions of SARS-CoV-2 Spike Glycoprotein with ACE2

Golcuk, M.; Yildiz, A.; Gur, M.

10.1101/2021.12.06.471377 — immunology — Posted on 2022-04-01

3758 High temperature molecular motions within a model protomembrane architecture

Misuraca, L.; Matsuo, T.; Disse, A.; LoRicco, J.; Calio, A.; Zanotti, J.-M.; Deme, B.; Oger, P. M.; Peters, J.

10.1101/2022.03.31.486527 — biophysics — Posted on 2022-04-01

3759 Computational design of ultrasensitive flexible peptide:receptor signaling complexes for enhanced chemotaxis

Jefferson, R. E.; Oggier, A.; Fuglistaler, A.; Camviel, N.; Hijazi, M.; Rico Villarreal, A.; Arber, C.; Barth, P.

10.1101/2022.03.30.486413 — biophysics — Posted on 2022-04-01

3760 One-sided design of protein-protein interaction motifs using deep learning

Syrlybaeva, R.; Strauch, E.-M.

10.1101/2022.03.30.486144 — biophysics — Posted on 2022-04-01

3761 mEos4b photoconversion efficiency depends on laser illumination conditions used in PALM

Wulffele, J.; Thedie, D.; Glushonkov, O.; Bourgeois, D.

10.1101/2022.03.31.486573 — biophysics — Posted on 2022-04-01

3762 PIEZO1-dependent erythrocyte dehydration as the mechanism for selection of an allele protecting from severe malaria.

Zimmerberg, J.; Glushakova, S. E.; Bezrukov, L.; Waters, H.; Kegawa, Y.; Blank, P. S.

10.1101/2022.03.31.486604 — biophysics — Posted on 2022-04-01

3763 Protons in gating the Kv1,2 channel: a calculated conformational change in response to addition of a proton, and a proposed path from voltage sensing domain to gate

Kariev, A. M.; Green, M. E.

10.1101/2022.03.31.486624 — biophysics — Posted on 2022-04-01

3764 Modelling biochemical gradients in vitro to control cell compartmentalization in a microengineered 3D model of the intestinal epithelium

Altay, G.; Abad-Lazaro, A.; Gualda, E. J.; Folch, J.; Insa, C.; Tosi, S.; Hernando-Momblona, X.; Batlle, E.; Loza, P.; Fernandez-Majada, V.; Martinez, E.

10.1101/2021.12.13.472418 — bioengineering — Posted on 2022-04-01

3765 Introgression between highly divergent sea squirt genomes: an adaptive breakthrough?

Fraisse, C.; Le Moan, A.; Roux, C.; Dubois, G.; Daguin-Thiebaut, C.; Gagnaire, P.-A.; Viard, F.; Bierne, N.

10.1101/2022.03.22.485319 — evolutionary biology — Posted on 2022-04-01

3766 Evolution of reduced mate-harming tendency of males in Drosophila melanogaster populations selected for faster life history

Verma, T.; Dasgupta, P.; Mohapatra, A.; Senapati, H. K.; Muni, R. K.; Nandy, B.

10.1101/2021.10.30.466596 — evolutionary biology — Posted on 2022-04-01

3767 Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

Wehling, L.; Keegan, L.; Fernandez-Palanca, P.; Hassan, R.; Ghallab, A.; Schmitt, J.; Schirmacher, P.; Kummer, U.; Hengstler, J. G.; Sahle, S.; Breuhahn, K.

10.1101/2022.03.31.486549 — molecular biology — Posted on 2022-04-01

3768 Prostaglandin D2 pathway in a transgenic rat model of Alzheimer's disease: therapeutic potential of timapiprant a DP2 antagonist

Wallace, C. H.; Oliveros, G. E.; Serrano, P. A.; Rockwell, P.; Xie, L.; Figueiredo-Pereira, M. E.

10.1101/2022.03.30.486444 — neuroscience — Posted on 2022-04-01

3769 Spontaneous thalamic activity modulates the cortical innervation of the primary visual nucleus of the thalamus

Moreno-Juan, V.; Anibal-Martinez, M.; Herrero-Navarro, A.; Vadeolmillos, M.; Martini, F.; Lopez-Bendito, G.

10.1101/2020.11.13.382366 — neuroscience — Posted on 2022-04-01

3770 Timing Is Everything In Autumn - Coordination Of Senescence Onset By A Transcriptional Program In Response To Environmental And Phytohormone Signals

Lihavainen, J.; Simura, J.; Bag, P.; Fataftah, N.; Robinson, K. M.; Delhomme, N.; Novak, O.; Ljung, K.; Jansson, S.

10.1101/2022.03.30.486406 — plant biology — Posted on 2022-04-01

3771 Prioritization of driver genes in cancer-associated copy number alterations identifies B4GALT5 as a glycooncogene

Parashuraman, S.; Sahu, P.; Russo, F.; Agliarulo, I.; Rizzo, R.; Lo Monte, M.; Normanno, N.; Soddu, S.; Carlomagno, F.; Luini, A.

10.1101/2022.03.30.486261 — cancer biology — Posted on 2022-04-01

3772 The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

Cathcart, A. L.; Havenar-Daughton, C.; Lempp, F. A.; Ma, D.; Schmid, M.; Agostini, M. L.; Guarino, B.; Di iulio, J.; Rosen, L.; Tucker, H.; Dillen, J.; Subramanian, S.; Sloan, B.; Bianchi, S.; Wojcechowskyj, J.; Zhou, J.; Kaiser, H.; Chase, A.; Lauron, E.; Montiel-Ruiz, M.; Spreafico, R.; Noack, J.; Czudnochowski, N.; Sahakyan, A.; Pinto, D.; Saliba, C.; Culap, K.; Delotta, E.; Park, A.; Cameroni, E.; Ledoux, S.; Kawaoka, Y.; Werts, A.; Colas, C.; Soriaga, L.; Telenti, A.; Purcell, L. A.; Hwang, S.; Snell, G.; Virgin, H. W.; Corti, D.; Hebner, C. M.

10.1101/2021.03.09.434607 — immunology — Posted on 2022-04-01

3773 Coding Recognition of the Dose-Effect Interdependence of Small Biomolecules Encrypted on Paired Chromatographic-Based Microassay Arrays

Deng, Y.; Lin, Z.; Cheng, Y.

10.1101/2021.03.10.434720 — biochemistry — Posted on 2022-04-01

3774 A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease

10.1101/2022.03.16.484543 — cell biology — Posted on 2022-04-01

3775 Microbial dysbiosis and metabolic disorders promote rheumatoid arthritis progression across successive stages

Cheng, M.; Zhao, Y.; Cui, Y.; Zha, Y.; Li, S.; Cao, G.; Li, M.; Zhang, L.; Ning, K.; Han, J.

10.1101/2022.02.13.480248 — microbiology — Posted on 2022-04-01

3776 Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

Bollmann, S.; Mattern, H.; Bernier, M.; Robinson, S. R.; Park, D.; Speck, O.; Polimeni, J. R.

10.1101/2021.06.09.447807 — neuroscience — Posted on 2022-04-01

3777 Sleep loss disrupts the neural signature of successful learning

Guttesen, A. a. V.; Gaskell, M. G.; Madden, E. V.; Appleby, G.; Cross, Z. R.; Cairney, S. A.

10.1101/2021.11.16.468870 — neuroscience — Posted on 2022-04-01

3778 Neprosin belongs to a new family of glutamic peptidase family based on in silico evidence

Ting, T. Y.; Baharin, A.; Ramzi, A. B.; Ng, C. L.; Goh, H.-H.

10.1101/2022.02.22.481544 — plant biology — Posted on 2022-04-01

3779 MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size

Lafferty, M. J.; Aygün, N.; Krupa, O.; Liang, D.; Wolter, J. M.; Geschwind, D. H.; de la Torre-Ubieta, L.; Stein, J. L.

10.1101/2022.03.31.486585 — genetics — Posted on 2022-04-01

Archive, 2022-04