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Archive, 2025-01

2 Cluster Assembly Dynamics Drive Fidelity of Planar Cell Polarity Polarization
Nissen, S. B.; Weiner, A. T.; Suyama, K. L.; Bosch, P. S.; Yu, M.; Song, S.; Gu, Y.; Dunn, A. R.; Axelrod, J. D.
10.1101/2024.10.21.619498 — cell biology — Posted on 2025-01-31
3 Novel Pannexin 1 isoform is increased in cancer
O'Donnell, B. L.; Stefan, D.; Chiu, Y.-H.; Zeitz, M.; Tang, J.; Johnston, D.; Leighton, S.; Van Kessell, C.; Barr, K.; Gyenis, L.; Freeman, T.; Kelly, J. J.; Sayedyahossein, S.; Isakson, B. E.; Litchfield, D. W.; Roth, K.; Smyth, J. W.; Hebb, M.; Ronald, J.; Bayliss, D. A.; Penuela, S.
10.1101/2024.09.09.612143 — cell biology — Posted on 2025-01-31
4 Human iPSC-derived muscle cells as a new model for investigation of EDMD1 pathogenesis.
Lisowska, M.; Rowinska, M.; Suszynska, A.; Bearzi, C.; Łaczmanska, I.; Hanusek, J.; Kunik, A.; Dzianisava, V.; Rzepecki, R.; Machowska, M.; Piekarowicz, K.
10.1101/2024.12.08.627381 — molecular biology — Posted on 2025-01-31
5 Mechanism of the Dual Action Self-Potentiating Antitubercular Drug Morphazinamide
Ostrer, L.; Crooks, T. A.; Howe, M. D.; Vo, S.; Jia, Z.; Hegde, P.; Schacht, N.; Aldrich, C. C.; Baughn, A. D.
10.1101/2024.10.08.617272 — microbiology — Posted on 2025-01-31
9 KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistance
Chatterjee, D.; Svoboda, R. A.; Huisman, D. H.; Drapkin, B. J.; Vieira, H. M.; Rao, C.; Askew, J. W.; Fisher, K. W.; Lewis, R. E.
10.1101/2024.02.23.581815 — cancer biology — Posted on 2025-01-31
10 Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling
Nakagawa, R.; Beardsley, A.; Durney, S.; Hayward, M.-K.; Subramanyam, V.; Meyer, N. P.; Wismer, H.; Goodarzi, H.; Weaver, V. M.; Van de Mark, D.; Goga, A.
10.1101/2024.09.26.615226 — cancer biology — Posted on 2025-01-31
11 Inhibitor-based modulation of huntingtin aggregation mechanisms mitigates fibril-induced cellular stress.
Jain, G.; Trombetta-Lima, M.; Matlahov, I.; Taborda Ribas, H.; Chen, T.; Parlato, R.; Portale, G.; Dolga, A. M.; van der Wel, P. C. A.
10.1101/2023.04.24.537565 — biophysics — Posted on 2025-01-31
15 The regulatory potential of transposable elements in maize
Bubb, K. L.; Hamm, M. O.; Tullius, T. W.; Min, J. K.; Ramirez-Corona, B.; Mueth, N. A.; Ranchalis, J.; Mao, Y.; Bergstrom, E. J.; Vollger, M. R.; Trapnell, C.; Cuperus, J. T.; Queitsch, C.; Stergachis, A. B.
10.1101/2024.07.10.602892 — genomics — Posted on 2025-01-31
19 Sperm derived H2AK119ub1 is required for embryonic development in Xenopus Laevis
Jullien, J.; Francois-Campion, V.; Berger, F.; Goumeidane, M.; Oikawa, M.; Gibeaux, R.; Peshkin, l.; Petrova, K.; Abreu, J.
10.1101/2024.04.23.590676 — developmental biology — Posted on 2025-01-31
20 Bacteriophage resistance evolution in a honey bee pathogen
Van Leuven, J.; Miller, C.; Peters, T.; Spencer, E.; Eline, Y.; Paull, K.; Saucedo, L.; Linzan, K.
10.1101/2024.07.09.602782 — microbiology — Posted on 2025-01-31
22 Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice
Khosravi-Maharlooei, M.; Vecchione, A.; Danzl, N.; Li, H. W.; Nauman, G.; Madley, R.; Waffarn, E.; Winchester, R.; Ruiz, A.; Ding, X.; Fousteri, G.; Sykes, M.
10.1101/2024.05.02.591692 — immunology — Posted on 2025-01-31
25 A toolbox for ablating excitatory and inhibitory synapses
Bareghamyan, A.; Deng, C.; Daoudi, S.; Yadav, S. C.; Lu, X.; Zhang, W.; Campbell, R. E.; Kramer, R.; Chenoweth, D. M.; Arnold, D. B.
10.1101/2024.09.23.614589 — neuroscience — Posted on 2025-01-31
27 Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition
Yang, H.; Wu, G.; Li, Y.; Xu, X.; Cong, J.; Xu, H.; Ma, Y.; Li, Y.; Chen, R.; Pines, A.; Xu, T.; Sydnor, V. J.; Satterthwaite, T. D.; Cui, Z.
10.1101/2023.03.08.531800 — neuroscience — Posted on 2025-01-31
28 Gradients of Recognition Molecules Shape Synaptic Specificity of Visuomotor Transformation
Dombrovski, M.; Zang, Y.; Frighetto, G.; Vaccari, A.; Jang, H.; Mirshahidi, P. S.; Xie, F.; Sanfilippo, P.; Hina, B. W.; Rehan, A.; Hussein, R. H.; Mirshahidi, P. S.; Lee, C.; Morris, A.; Frye, M. A.; von Reyn, C. R.; Kurmangaliyev, Y. Z.; Card, G. M.; Zipursky, S. L.
10.1101/2024.09.04.610846 — neuroscience — Posted on 2025-01-31
29 Small molecule-controlled gene expression: Design of drug-like high affinity small molecule modulators of a custom-made riboswitch
Hedwig, V.; Spoering, M.; Aspnes, G.; Gottschling, D.; Klein, H.; Klugmann, M.; Kreuz, S.; Ries, B.; Schnapp, G.; Scharsich, S.; Hartig, J.; Hucke, O.
10.1101/2025.01.21.634073 — synthetic biology — Posted on 2025-01-31
30 Loss of CTRP10 results in female obesity with preserved metabolic health
Chen, F.; Sarver, D. C.; Saqib, M.; Velez, L. M.; Aja, S.; Seldin, M. M.; Wong, G. W.
10.1101/2023.11.01.565163 — physiology — Posted on 2025-01-31
33 An HIV-1 Reference Epitranscriptome
Bosmeny, M. S.; Pater, A. A.; Zhang, L.; Sha, B. E.; Lyu, Z.; Larkai, L.; Damha, M. J.; Mamede, J. I.; Gagnon, K. T.
10.1101/2025.01.30.635805 — genetics — Posted on 2025-01-31
34 Safe focused ultrasound-mediated blood-brain barrier opening is driven primarily by transient reorganization of tight junctions
Noel, R. L.; Kugelman, T.; Karakatsani, M. E.; Shahriar, S.; Willner, M. J.; Choi, C. S.; Nimi, Y.; Ji, R.; Agalliu, D.; Konofagou, E. E.
10.1101/2025.01.28.635258 — bioengineering — Posted on 2025-01-31
36 Structural and Functional Versatility of the Amyloidogenic Antimicrobial Peptide Citropin 1.3
Strati, F.; Pigozzi Cali, M.; Bloch, Y.; Mostafavi, S.; Monistrol, J.; Golubev, A.; Rayan, B.; Gustavsson, E.; Landau, M.
10.1101/2025.01.31.635854 — molecular biology — Posted on 2025-01-31
38 Biological Drivers of Early Childhood Caries in Preschool Children of Northern Arizona and Hawaii
Whealy, R. N.; Furstenau, T.; Roberts, A.; Cocking, J.; Erickson, D. E.; Brock, B.; McCormick, R.; Timm, S.; Pacheco, M.; Mochida-Meek, S.; Fofanov, V.
10.1101/2025.01.30.635340 — microbiology — Posted on 2025-01-31
39 SEVI Fibrils are Induced by Bacterial Surface Molecules and Exert Antimicrobial Activity Against ESKAPE Pathogens
Vogel, V.; Olari, L. R.; Bauer, R.; Burczyk, S.; Witz, F.; Walker, E.; Jaber, N.; Rupp, U.; Stifel, U.; Zinngrebe, J.; Read, C.; Fischer-Posovszky, P.; Münch, J.; Spellerberg, B.
10.1101/2025.01.31.635909 — microbiology — Posted on 2025-01-31
41 Adaptive strategies of Caribbean sponge holobionts beyond the mesophotic zone
Paix, B.; Thivet, A.; Domingos, C.; Erol, O.; van der Windt, N.; Choi, Y. H.; de Voogd, N. J.
10.1101/2025.01.31.635867 — microbiology — Posted on 2025-01-31
42 Hyaluronic acid hydrogels: Establishing a sustained delivery system for extracellular vesicles
Chabria, Y.; O'Dwyer, J.; McDermott, E.; Owens, P.; Lowery, A. J.; Duffy, G. P.; Dwyer, R. M.
10.1101/2025.01.29.635521 — bioengineering — Posted on 2025-01-31
44 On the transient interactions of α-synuclein in different dimensions
Ortigosa-Pascual, L.; Ferrante Carrante, N.; Bernfur, K.; Makasewicz, K.; Sparr, E.; Linse, S.
10.1101/2025.01.29.635265 — biochemistry — Posted on 2025-01-31
45 1,2,4-Triazole-based first-in-class non-nucleoside inhibitors of bacterial enzyme MraY
Roy, S.; Berida, T.; Huang, T.-Y.; Weck, S. C.; Lutz, M.; McKee, S. R.; Kagerah, N.; Manning, D. L.; Jahan, M. E.; Mishra, S. K.; Doerksen, R. J.; Stallings, C. L.; Ducho, C.
10.1101/2025.01.30.635793 — biochemistry — Posted on 2025-01-31
46 Phylodynamic estimation of the within-host mutation rate of extended-spectrum beta-lactamase-producing Enterobacterales
Aguilar Bultet, L.; Windels, E. M.; Vock, I.; Maurer Perkerman, L.; Tschudin Sutter, S.; Stadler, T.
10.1101/2025.01.31.635889 — genomics — Posted on 2025-01-31
47 The KRAB-Zinc Finger protein ZKSCAN3 represses enhancers via embedded retrotransposons
Moore, D.; Wong, E.; Arnal, C.; Schoenfelder, S. W.; Spivakov, M.; Andrews, S.; Christophorou, M. A.
10.1101/2025.01.30.635440 — molecular biology — Posted on 2025-01-31
48 The core MICOS complex subunit Mic60 has been substituted by two cryptic mitofilin-containing proteins in Euglenozoa
Sheikh, S.; Turpin Knotkova, B.; Benz, C.; Elias, M.; Bily, T.; Bondar, A.; Tesarova, M.; Stribrna, E.; Heller, J.; Meinecke, M.; Hashimi, H.
10.1101/2025.01.31.635831 — molecular biology — Posted on 2025-01-31
50 High throughput protein serial crystallography using a grease matrix and a large-area support film
Sugahara, M.; Maki-Yonekura, S.; Inoue, I.; Takaba, K.; Narai, S.; Naitow, H.; Kang, J.; Tono, K.; Numata, K.; Ishikawa, T.; Yabashi, M.; Yonekura, K.
10.1101/2025.01.31.635837 — molecular biology — Posted on 2025-01-31
51 A molecular switch at the yeast mitoribosomal tunnel exit controls cytochrome b synthesis
Carlstrom, A.; Bridgers, J. B.; Couvillion, M.; Singh, A. P.; Forne, I.; Imhof, A.; Churchman, L. S.; Ott, M.
10.1101/2025.01.30.635641 — molecular biology — Posted on 2025-01-31
55 Unfolded protein response is a critical mediator in Campylobacter jejuni pathogenesis and host defence
Hong, G.; Omole, Z.; Davies, C.; Liaw, J.; Grabowska, A. D.; Canonico, B.; Corcionivoschi, N.; Wren, B. W.; Dorrell, N.; Elmi, A.; Gundogdu, O.
10.1101/2025.01.31.635839 — microbiology — Posted on 2025-01-31
56 Antiviral activity of rosemary extract against Zika virus in human dermal fibroblasts
Masi, J. T.; Crozier, R. W. E.; Coish, J. M.; Hicks, N. J.; Tsiani, E.; Patterson, E. I.; MacNeil, A. J.
10.1101/2025.01.30.635802 — microbiology — Posted on 2025-01-31
57 Statins do not reduce the parasite burden during experimental Trypanosoma cruzi infection
Razzaq, S.; Olmo, F.; Lakshminarayana, S. B.; Ying-Bo, C.; Jayawardhana, S.; Rao, S. P. S.; Kelly, J. M.; Fortes Francisco, A.
10.1101/2025.01.30.635783 — microbiology — Posted on 2025-01-31
58 Enterococcus faecalis-derived lactic acid facilitates persistent and polymicrobial wound infections by suppressing macrophage activation
da Silva, R. A. G.; Tien, B. Y. Q.; Kao, P. H. N.; Celik, C.; Tan, A. Z. C.; Ismail, M. H.; Hu, G.; Chong, K. K. L.; Thibault, G.; Chen, J.; Kline, K. A.
10.1101/2025.01.31.635924 — microbiology — Posted on 2025-01-31
61 Sources of non-uniform coverage in short-read RNA-Seq data
Brooks, T. G.; Lahens, N. F.; Mrcela, A.; Yang, J.; Purohit, S.; Naik, A.; Ricciotti, E.; Sengupta, S.; Choi, P.; Grant, G. R.
10.1101/2025.01.30.634337 — bioinformatics — Posted on 2025-01-31
62 Pathological mutation in SMN impairs modulation of GAR1 phase separation linking condensate dysfunction to Spinal Muscular Atrophy
Felix, S. S.; O'Toole, P.; Oliveira, N. A. S.; Pinho, B. R.; Blacker, T. S.; Fernandes, F.; Oliveira, J. M. A.; Oroz, J.; Laurents, D. V.; Cabrita, E. J.
10.1101/2025.01.30.635772 — biochemistry — Posted on 2025-01-31
65 Müllerian mimicry in Neotropical butterflies: One mimicry ring to bring them all, and in the jungle bind them
Perochon, E.; Rosser, N.; Kozak, K.; McMillan, W. O.; Huertas, B.; Mallet, J.; Ready, J.; Willmott, K.; Elias, M.; Dore, M.
10.1101/2025.01.30.635679 — evolutionary biology — Posted on 2025-01-31
67 Genome-scale transcriptome augmentation during Arabidopsis thaliana photomorphogenesis
Schivre, G.; Wolff, L.; Mirasole, F. M.; Armanet, E.; Davidson, M. L.. H.; Vidal, A.; Cumenal, D.; Dumont, M.; Bourge, M.; Baroux, C.; Bourbousse, C.; Barneche, F.
10.1101/2025.01.30.635720 — plant biology — Posted on 2025-01-31
69 CRISPR screening reveals SYCP3 as a key driver of metastasis in prostate cancer
Rodrigo-Faus, M.; del Monte-Garcia, I.; Hermosilla-Trespaderne, M.; Gordo-Vega, A.; Vidal, N.; Puente, J.; Saiz-Pardo, M.; Cuesta, A. M.; Qu, H.-Q.; Hakonarson, H.; Porras, A.; Sanchez Parcerisa, D.; Bragado, P.; Gutierrez-Uzquiza, A.
10.1101/2025.01.30.629925 — cancer biology — Posted on 2025-01-31
72 Admixture mapping reveals evidence for multiple mitonuclear incompatibilities in swordtail fish hybrids
Robles, N. V.; Moran, B. M.; Rodriguez Barrera, M. J.; Jofre, G. I.; Gunn, T.; Iverson, E. N. K.; Beskid, S.; Baczenas, J.; Sedghifar, A.; Andolfatto, P.; Brandvain, Y.; Havird, J. C.; Rosenthal, G. G.; Schumer, M.
10.1101/2025.01.30.635158 — evolutionary biology — Posted on 2025-01-31
75 Clinical relevance of zebrafish for gene variants testing. Proof-of-principle with SMN1/SMA.
Stringer, B. W.; Zhang, Y.; Taghipour-Sheshdeh, A.; Goh, S.; Kolbel, H.; Farrar, M. A.; Wirth, B.; Giacomotto, J.
10.1101/2025.01.30.632288 — neuroscience — Posted on 2025-01-31
76 Microglial plasticity governed by state-specific enhancer landscapes
Hamagami, N.; Kapadia, D.; Abduljawad, N.; Cheng, Z.; McLaughlin, L.; Singhania, D.; Barclay, K.; Yang, J.; Sun, Z.; Bayguinov, P.; Yu, G.; Gabel, H.; Li, Q.
10.1101/2025.01.30.635595 — neuroscience — Posted on 2025-01-31
78 A-beta-induced distress of astrocytes triggers Alzheimer disease pathology through non-canonical delta secretase activity
Willnow, T.; Schmidt, V.; Malik, A.; Ziemlinska, E.; Obrebski, T.; Zurawska-Plaksej, E.; Cendrowski, J.; Hempstead, B. L.
10.1101/2025.01.30.635618 — neuroscience — Posted on 2025-01-31
80 Endogenous recovery of hippocampal function following global cerebral ischemia in juvenile female mice is influenced by neuroinflammation and circulating sex hormones.
Vigil, J. J.; Tiemeier, E.; Orfila, J. E.; Chalmers, N. E.; Chang, V. N.; Mitchell, D.; Veitch, I.; Falk, M.; Dietz, R. M.; Herson, P. S.; Quillinan, N. J.
10.1101/2025.01.28.635301 — neuroscience — Posted on 2025-01-31
83 Blood mitochondrial health markers cf-mtDNA and GDF15 in human aging
Trumpff, C.; Huang, Q.; Michelson, J.; Liu, C. C.; Shire, D.; Habeck, C. G.; Stern, Y.; Picard, M.
10.1101/2025.01.28.635306 — physiology — Posted on 2025-01-31
84 Cholangiocytes' Primary Cilia Regulate DNA Damage Response and Repair
Peixoto, E.; Pant, K.; Richard, S.; Abrahante, J. E.; Czaja, W.; Gradilone, S.
10.1101/2025.01.28.635267 — pathology — Posted on 2025-01-31
89 DNA from cetariae fish remains confirms sardine (Sardina pilchardus) use and local population continuity in Northwestern Iberia since Roman times
Themudo, G. E.; Fernandez-Fernandez, A.; Abad, P. V.; Novoa, A. A. R.; Fernandez-Rodriguez, C.; de Aguero, E. G.-G.; da Fonseca, R. R.; Campos, P. F.
10.1101/2025.01.28.635260 — evolutionary biology — Posted on 2025-01-31
91 Intense oocyte competition builds the female reproductive reserve in mice
Zhang, H.; Zhang, Y.; Bo, Y.; Cheng, K.; Mu, L.; Liang, J.; Li, L.; Hu, X.; Wang, G.; Geng, K.; Yang, X.; Wang, W.; Jia, L.; Xu, X.; Hu, J.; Wang, C.; Ke, Y.; Xia, G.
10.1101/2025.01.30.635812 — developmental biology — Posted on 2025-01-31
95 Decoding auditory working memory content from EEG aftereffects of auditory-cortical TMS
Uluc, I.; Daneshzand, M.; Jas, M.; Kotlarz, P.; Lankinen, K.; Fiedler, J.; Mamashli, F.; Pajankar, N.; Turpin, T.; Navarro de Lara, L.; Sundaram, P.; Raij, T.; Nummenmaa, A.; Ahveninen, J.
10.1101/2024.03.04.583379 — neuroscience — Posted on 2025-01-31
97 Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in aged mice
Villarroel-Campos, D.; Rhymes, E. R.; Tosolini, A. P.; Malik, B.; Vagnoni, A.; Schiavo, G.; Sleigh, J. N.
10.1101/2025.01.30.635507 — neuroscience — Posted on 2025-01-31
100 Deuterium labeling enables proteome wide turnover kinetics analysis in cell culture
Alamillo, L.; Ng, D. C. M.; Currie, J.; Black, A.; Pandi, B.; Manda, V.; Pavelka, J.; Schaal, P.; Travers, J. G.; McKinsey, T. A.; Lam, M. P. Y.; Lau, E.
10.1101/2025.01.30.635596 — biochemistry — Posted on 2025-01-31
101 Novel Laser Technology Enables 10x Faster SRS Imaging and Rapid Tuning in Biological Samples
Reinkensmeier, L.; Siegmund, R.; Bates, M.; Stibenz, G.; Trabs, P.; Popien, S.; Rimke, I.; Heuke, S.; Egner, A.
10.1101/2025.01.31.635524 — biophysics — Posted on 2025-01-31
104 Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Iden-tify Covalent TLCD1 Inhibitors
Sharma, H. A.; Bielecki, M.; Holm, M. A.; Thompson, T. M.; Yin, Y.; Cravatt, J. B.; Ware, T. B.; Reed, A.; Nassir, M.; El-Hayek Ewing, T.; Melillo, B.; Bazan, J. F.; Baran, P. S.; Cravatt, B.
10.1101/2025.01.31.635883 — biochemistry — Posted on 2025-01-31
113 Mutations in SOD1 induce ALS-related phenotypes in 3D iPSC-derived motor neuron (MN) spheroids
Castellanos-Montiel, M. J.; Franco-Flores, A. K.; Nicouleau, M.; Haghi, G.; Lepine, S.; Baeza, B.; Chen, C. X.- Q.; Goldsmith, T. M.; Aprahamian, N.; Hua, D.; Chaineau, M.; Gursu, L.; Abdian, N.; Deneault, E.; Durcan, T. M.
10.1101/2025.01.28.635126 — neuroscience — Posted on 2025-01-31
114 Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli
Droghetti, R.; Fuchs, P.; Iuliani, I.; Firmano, V.; Tallarico, G.; Calabrese, L.; Grilli, J.; Sclavi, B.; Ciandrini, L.; Cosentino Lagomarsino, M.
10.1101/2023.10.25.563923 — systems biology — Posted on 2025-01-31
116 High-Throughput Glycan Array Screening Reveals Rhamnogalacturonan-I as a Ligand for Arabidopsis Leucine-Rich Repeat Receptor Kinases
LEE, D.; Ruprecht, C.; Lee, J.-M.; Choi, M.-S.; Hrovat, T.; Heo, G.; Edelbacher, N.; Enugutti, B.; Blaukopf, M.; Cho, C. H.; Lee, H.-S.; Belkhadir, Y.; Smakowska-Luzan, E.; Pfrengle, F.
10.1101/2025.01.29.635407 — plant biology — Posted on 2025-01-31
117 Endogenous RALF peptide function is required for powdery mildew host colonization
Leicher, H.; Schade, S.; Huebbers, J. W.; Munzert-Eberlein, K. S.; Haljiti, G.; Ludwig, C.; Mueller, M.; Kinoshita, T.; Engelsdorf, T.; Hueckelhoven, R.; Stegmann, M.
10.1101/2025.01.30.635691 — plant biology — Posted on 2025-01-31
118 The Arabidopsis TNL immune receptor BNT1 localizes to the plastid envelope and mediates flg22-induced resistance against Pseudomonas
Margutti, M. Y. P.; Cislaghi, A. P.; Herrera-Vasquez, A.; Palomeque, J. R.; Bellino, F.; Alvarez, M. E.; Blanco-Herrera, F.; Cecchini, N. M.
10.1101/2025.01.29.635455 — plant biology — Posted on 2025-01-31
120 Immunity gene silencing increases transient protein expression in Nicotiana benthamiana
Dodds, I. L.; Watts, E. C.; Schuster, M.; Buscaill, P.; Tumtas, Y.; Holton, N. J.; Song, S.-j.; Stuttmann, J.; Joosten, M. H. A. J.; Bozkurt, T. O.; van der Hoorn, R. A. L.
10.1101/2025.01.30.635616 — plant biology — Posted on 2025-01-31
121 Functional Modulation of Retrotrapezoid Neurons Drives Fentanyl-Induced Respiratory Depression
Moreira, T. S.; Burgraff, N. J.; Takakura, A. C.; Oliveira, L. M.; Araujo, E. V.; Guan, S.; Ramirez, J.-M.
10.1101/2025.01.28.635295 — physiology — Posted on 2025-01-31
122 Unveiling Hidden Microbial Diversity in Mars 2020 Mission Assembly Cleanrooms with Molecular Insights into the Persistent and Perseverance of Novel Species Defying Metagenome Sequencing
Muthamilselvi Sivabalan, S. K.; Vijayakumar, V.; Sengupta, P.; Palmal, S.; Krishnamurthi, S.; Kumar Singh, N.; Kyrpides, N. C.; Raman, K.; Venkateswaran, K.
10.1101/2025.01.21.633868 — genomics — Posted on 2025-01-31
123 Recent emergence of cephalosporin resistant Salmonella Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding blaCTX-M-15 gene
Thirumoorthy, T. P.; Jacob, J. J.; Velmurugan, A.; Teekaraman, M. P.; Shah, B. S.; Iyer, V.; Maheshwari, G.; Trivedi, U.; Shah, A.; Patel, P.; Gaigawale, A.; M, Y.; Sathya Narayanan, P.; Mutreja, A.; Carey, M.; John, J.; Kang, G.; Veeraraghavan, B.
10.1101/2023.07.05.547856 — genomics — Posted on 2025-01-31
124 A human organoid model of alveolar regeneration reveals distinct epithelial responses to interferon-gamma
Dost, A. F. M.; Balazova, K.; Pou Casellas, C.; van Rooijen, L. M.; Epskamp, W.; van Son, G. J. F.; Wetering, W. J.; Lopez-Iglesias, C.; Begthel, H.; Peters, P. J.; Smakman, N.; van Es, J. H.; Clevers, H.
10.1101/2025.01.30.635624 — cell biology — Posted on 2025-01-31
125 Bidirectional Peptide Conformation Prediction for MHC Class II using PANDORA
Rademaker, D. T.; Parizi, F. M.; van Vreeswijk, M.; Eerden, S.; Marzella, D.; Xue, L.
10.1101/2024.11.04.621877 — immunology — Posted on 2025-01-31
126 Multimodal synapse analysis reveals restricted integration of transplanted neurons remodeled by TREM2
Zarb, Y.; Thorwirth, M.; Markkula, O.; Paoli, E.; Martinez-Reza, M. F.; Todorov, M.; Koupoutidou, C.; Schwarz, V.; Kislinger, G.; Mezydlo, A.; Puglisi, M.; Willem, M.; Ninkovic, J.; Conzelmann, K.-K.; Schifferer, M.; Haass, C.; Kerschensteiner, M.; Portugues, R.; Kopp-Scheinpflug, C.; Goetz, M.
10.1101/2025.01.31.635250 — neuroscience — Posted on 2025-01-31
127 Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers in metazoans
Liu, T.; Cao, L.; Mladenov, M.; Romet-Lemonne, G.; Way, M.; Moores, C.
10.1101/2025.01.31.635869 — biophysics — Posted on 2025-01-31
128 Emergence of binding and catalysis from a designed generalist binding protein
Chen, Y.; Bhattacharya, S.; Bergmann, L.; Correy, G. J.; Tan, S.; Hou, K.; Biel, J.; Lu, L.; Bakanas, I.; Polizzi, N. F.; Fraser, J. S.; DeGrado, W. F.
10.1101/2025.01.30.635804 — biophysics — Posted on 2025-01-31
130 Single cell-resolved transcriptional dynamics of human subcutaneous adipose tissue during lifestyle- and bariatric surgery-induced weight loss
Loft, A.; Rydbirk, R.; Klinggaard, E. G.; van Hauwaert, E. L.; Wernberg, C. W.; Moller, A. F.; Dam, T. V.; Hassan, M. N.; Maniyadath, B.; Nielsen, R.; Krag, A.; Kalucka, J.; Schmidt, S. F.; Lauridsen, M. E. M.; Madsen, J. G. S.; Mandrup, S.
10.1101/2025.01.30.634294 — cell biology — Posted on 2025-01-31
132 The city and forest bird flock together in a common garden: genetic and environmental effects drive urban phenotypic divergence
Thompson, M. J.; Reale, D.; Chenet, B.; Delaitre, S.; Fargevieille, A.; Romans, M.; Caro, S. P.; Charmantier, A.
10.1101/2024.08.27.609854 — evolutionary biology — Posted on 2025-01-31
134 CD300f immune receptor is a microglial tissue damage sensor and regulates efferocytosis after brain damage
Negro-Demontel, M. L.; Evans, F.; Cawen, F. A.; Fitzpatrick, Z.; Mason, H. D.; Ali-Ruiz, D.; Peluffo, H.
10.1101/2024.09.06.611174 — neuroscience — Posted on 2025-01-31
140 Aging: an inevitable road toward gut microbiota pathoadaptation
Melo-Miranda, R.; Pinto, A.; Barreto, H. C.; Jesus, C.; Gordo, I.; Duarte, I.; Sousa, A.
10.1101/2025.01.29.635424 — evolutionary biology — Posted on 2025-01-31
141 Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes
Cao, Y.; Redd, M. A.; Outhwaite, J. E.; Mizikovsky, D.; Shim, W. J.; Fang, C.; Wu, Z.; Daygon, D.; Stark, T.; Palfreyman, R.; Chiu, H. S.; Tan, C.; Thomas, U.; Dragicevic, E.; Sng, J.; Barrett, H.; Dorey, E.; Shah, S.; Short, K.; Palpant, N. J.
10.1101/2025.01.29.635173 — cell biology — Posted on 2025-01-31
142 High-Throughput Site-Specific N-Glycosylation Profiling of Human Fibrinogen in Atrial Fibrillation
Soic, D.; Kifer, D.; Szavits-Nossan, J.; Blivajs, A.; Derek, L.; Rudan, D.; Gornik, O.; Gudelj, I.; Keser, T.
10.1101/2025.01.29.635427 — molecular biology — Posted on 2025-01-31
143 Distinct bacterial and protist plankton diversity dynamics uncovered through DNA-based monitoring in the Baltic Sea area
Jurdzinski, K. T.; Latz, M. A.; Torstensson, A.; Brugel, S.; Hedblom, M.; Hu, Y. O. O.; Lindh, M.; Andersson, A.; Karlson, B.; Andersson, A. F.
10.1101/2024.08.14.607742 — microbiology — Posted on 2025-01-31
144 HIV-1 Rebound Virus Consists of a Small Number of Lineages That Entered the Reservoir Close to ART Initiation
Tyers, L.; Ntuli, J.; Moeser, M.; Council, O.; Zhou, S.; Spielvogel, E.; Sondgeroth, A.; Adams, C.; Thebus, R.; Yssel, A.; Karim, S. A.; Garrett, N.; Pond, S. K.; Williamson, C.; Swanstrom, R.; Abrahams, M.-R.; Joseph, S. B.
10.1101/2025.01.29.635391 — microbiology — Posted on 2025-01-31
145 Lower cortical FKBP5 DNA methylation at key enhancer sites is associated with older age and higher gene expression in schizophrenia
Edmond, K. Z.; Kaul, D.; Yusupov, N.; Ködel, M.; Sauer, S.; Fröhlich, A. S.; Tao, R.; Kleinman, J. E.; Weinberger, D.; Hyde, T. M.; Czamara, D.; Binder, E. B.; Matosin, N.
10.1101/2025.01.28.635384 — neuroscience — Posted on 2025-01-31
146 No single PCR test is sufficient to determine parvovirus IHHNV presence in or impact on farmed shrimp production
Sritunyalucksana, K.; Sanguanrut, P.; Srisala, J.; Thawonsuwan, J.; Saleetid, N.; Vanichviriyakit, R.; Chotwiwatthanakun, C.; FLEGEL, T. W.; Taengchaiyaphum, S.
10.1101/2023.09.08.556791 — zoology — Posted on 2025-01-31
151 The current landscape and emerging challenges of benchmarking single-cell methods
Yang, J. Y. H.; Cao, Y.; Yu, L.; Torkel, M.; Kim, S.; Lin, Y.; Yang, P.; Speed, T. P.; Ghazanfar, S.
10.1101/2023.12.19.572303 — bioinformatics — Posted on 2025-01-31
153 Unsupervised Detection of Rare Events in Liquid Biopsy Assays
Murgoitio-Esandi, J.; Tessone, D.; Naghdloo, A.; Shishido, S. N.; Zhang, B.; Xu, H.; Dasgupta, A.; Mason, J.; Nagaraju, R. M.; Hicks, J.; Kuhn, P.; Oberai, A. A.
10.1101/2025.01.29.635501 — bioinformatics — Posted on 2025-01-31
154 Dimeric R25CPTH(1-34) Activates the Parathyroid Hormone-1 Receptor in vitro and Stimulates Bone Formation in Osteoporotic Female Mice
Noh, M.; Che, X.; Jin, X.; Lee, D.-K.; Kim, H.-J.; Park, D. R.; Lee, S. Y.; Lee, H.; Gardella, T. J.; Choi, J.-Y.; Lee, S.
10.1101/2024.03.13.584815 — genomics — Posted on 2025-01-31
156 Structure and dynamics determine G protein coupling specificity at a class A GPCR
Casiraghi, M.; Wang, H.; Brennan, P.; Habrian, C.; Hubner, H.; Schmidt, M. F.; Maul, L.; Pani, B.; Bahriz, S. M.; Xu, B.; White, E.; Sunahara, R. K.; Xiang, Y. K.; Lefkowitz, R. J.; Isacoff, E. Y.; Nucci, N.; Gmeiner, P.; Lerch, M.; Kobilka, B. K.
10.1101/2024.03.28.587240 — molecular biology — Posted on 2025-01-31
157 Density-dependent expression of epitranscriptomic, stress, and appetite regulating genes in Atlantic salmon
Frapin, M.; Quispe, L.; Troka, J.; Prokkola, J. M.; Laurikainen, O.; Hyvärinen, P.; Primmer, C. R.; Aykanat, T.; Ahi, E. P.
10.1101/2025.01.19.633827 — molecular biology — Posted on 2025-01-31
161 Balancing postural control and motor inhibition during gait initiation
Fiori, L.; Ramawat, S.; Marc, I. B.; Giuffrida, V.; Ranavolo, A.; Draicchio, F.; Pani, P.; Ferraina, S.; Brunamonti, E.
10.1101/2024.05.16.594550 — neuroscience — Posted on 2025-01-31
163 Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration.
Cueva Vargas, J. L.; Belforte, N.; Vidal-Paredes, I. A.; Dotigny, F.; Vande Velde, C.; Quintero, H.; Di Polo, A.
10.1101/2024.12.21.629919 — neuroscience — Posted on 2025-01-31
164 Heterochronous laminar maturation in the human prefrontal cortex
Sydnor, V. J.; Petrie, D.; McKeon, S. D.; Famalette, A.; Foran, W.; Calabro, F. J.; Luna, B.
10.1101/2025.01.30.635751 — neuroscience — Posted on 2025-01-30
166 Gene regulatory mechanisms underlying evolutionary adaptations of homologous neuronal cell types
Flames, N.; Millan-Trejo, A.; Mora-Martinez, C.; Tarazona-Sanchez, A.; Lloret-Fernandez, C.; Alis, R.; Jordan, A.; Barrios, A.
10.1101/2025.01.30.635650 — evolutionary biology — Posted on 2025-01-30
167 Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation
Brinkmeier, M.; Cheung, L. Y. M.; O'Connell, S. P.; Gutierrez, D. K.; Rhoads, E. C.; Camper, S. A.; Davis, S. W.
10.1101/2025.01.30.635771 — developmental biology — Posted on 2025-01-30
169 Conjugative Plasmids Rarely Confer Antibiotic Resistance or Virulence
Domingues, C. P. F.; Rebelo, J. S.; Dionisio, F.; Nogueira, T. I.
10.1101/2025.01.30.635773 — genomics — Posted on 2025-01-30
170 An experimental approach to understanding plastic leachate impacts on marine microorganisms
Maday, S.; Handley, K. M.; Northcott, G.; KIngsbury, J.; Smith, D.; Pantos, O.; Lear, G.
10.1101/2025.01.30.635782 — microbiology — Posted on 2025-01-30
176 Analytical Ultracentrifugation as a Tool for Exploring COSAN Assemblies.
Fakhouri, H.; Mas, C.; Le Roy, A.; Marchal, E.; Pasquier, C.; Diat, O.; Bauduin, P.; Ebel, C.
10.1101/2025.01.30.635703 — biophysics — Posted on 2025-01-30
177 SHINE: SERS-based Hepatotoxicity detection using Inference from Nanoscale Extracellular vesicle content
Parlatan, U.; boudreau, L.; Torun, H.; Fan, L.; Aygun, U.; Gokaltun, A. A.; Akin, D.; Usta, O. B.; Demirci, U.
10.1101/2025.01.30.635446 — biophysics — Posted on 2025-01-30
179 Cracking Controls ATP Hydrolysis in the catalytic domain of a P-ATPase
Placenti, M. A.; Gache, S. A.; Gonzalez-Lebrero, R. M.; Wolynes, P. G.; Flecha, F. L. G.; Roman, E. A.
10.1101/2025.01.29.635504 — biophysics — Posted on 2025-01-30
181 Single-AAV CRISPR editing of skeletal muscle in non-human primates with NanoCas, an ultracompact nuclease
Rauch, B. J.; DeLoughery, A.; Sper, R.; Chen, S.; Yunanda, S.; Masnaghetti, M.; Chai, N.; Lin, J. C.; Neckelmann, A.; Bjornson, Y.; Espino, D. P.; Sancio, A.; Schmitt, C.; Scholes, C.; Shah, R.; Narendra, P. K.; Ansaloni, S.; Tan, S.; Rukmini, S. J.; Somaiah, S.; Suresh, S.; Minami, S.; Tymoshenko, S.; Wright, W.; Xu, S.; Broughton, J.; Retwitzer, M. D.; Bobbin, M.; Yuan, D.; Abe, K.; DeWitt, M.; Zhang, B.; Harrington, L. B.
10.1101/2025.01.29.635576 — bioengineering — Posted on 2025-01-30
182 AmpliconTyper tool for analysing ONT multiplex PCR data from environmental and other mixed sources
Spadar, A.; Mahindroo, J.; Troman, C.; Owusu, M.; Abu-Sarkodie, Y.; Owusu-Dabo, E.; Abraham, D.; Blossom, B.; Govindan, K.; Mohan, V. R.; Dyson, Z. A.; Grassly, N. C.; Holt, K.
10.1101/2025.01.30.635642 — genomics — Posted on 2025-01-30
185 Candidate transmission survival genome of Mycobacterium tuberculosis
Mishra, S.; Singh, P. R.; Hu, X.; Lopez-Quezada, L.; Jinich, A.; Jahn, R.; Geurts, L.; Shen, N.; DeJesus, M.; Hartman, T.; Rhee, K. Y.; Zimmerman, M.; Dartois, V. A.; Jones, R. M.; Jiang, X.; Almada-Monter, R.; Bourouiba, L.; Nathan, C. F.
10.1101/2025.01.30.635747 — microbiology — Posted on 2025-01-30
190 Genomic and Transcriptomic Characterization of Carbohydrate-Active Enzymes in the Anaerobic Fungus Neocallimastix cameroonii var. constans
Blair, E. M.; Navaratna, T. A.; Ahern, C. B.; Ragunathan, R.; Brown, J. L.; Mondo, S. J.; Lipzen, A.; Hanafy, R. A.; LaButti, K.; Talag, J.; Barry, K.; Chovatia, M.; Wang, M.; Gonzalez, J.; Peng, X.; Grigoriev, I. V.; O'Malley, M.
10.1101/2025.01.29.635548 — microbiology — Posted on 2025-01-30
191 Major antigenic differences in Aeromonas salmonicida isolates correlate with the emergence of a new strain causing furunculosis in Chilean salmon farms
Mancilla, M.; Ojeda, A.; Yuivar, Y.; Grandon, M.; Grothusen, H.; Oyarzun, M.; Bisquertt, A.; Ugalde, J.; Fuentes, F.; Ibarra, P.; Bustos, P.
10.1101/2025.01.30.635334 — microbiology — Posted on 2025-01-30
196 Stiffening cells with light
Gonzalez, E.; El Husseiny, J.; Molzahn, F. B.; Campion, T.; Jalaber, H.; Dogniaux, S.; Puech, P.-H.; Nüsse, O.; Gibot, L.; Husson, J.
10.1101/2025.01.30.635790 — biophysics — Posted on 2025-01-30
199 ChiraKit, an online tool for the analysis of circular dichroism spectroscopy data
Burastero, O.; Jones, N.; Defelipe, L. A.; Zavrtanik, U.; Hadzi, S.; Hoffmann, S. V.; Garcia-Alai, M. M.
10.1101/2025.01.29.635490 — biophysics — Posted on 2025-01-30
200 Inferring active and passive mechanical drivers of epithelial convergent extension
Anjum, S.; Vijayraghavan, D.; Fernandez-Gonzalez, R.; Sutherland, A.; Davidson, L.
10.1101/2025.01.28.635314 — biophysics — Posted on 2025-01-30
204 Optimizing DNA origami assembly through selection of scaffold sequences that minimise off-target interactions
Shirt-Ediss, B.; Torelli, E.; Navarro, S. A.; Khamis, H.; Kaplan, A.; Trewby, W.; Elezgaray, J.; Moradzadeh-Esmaeili, N.; Haydell, M.; Keppner, D.; Famulok, M.; Krasnogor, N.
10.1101/2025.01.29.635450 — bioengineering — Posted on 2025-01-30
205 Mdm38/LETM1 couples ion homeostasis and proteostatic mechanisms in the inner mitochondrial membrane
Bohovych, I.; da Silva, G. M.; Ali, S. F.; Bergmeyer, E. J.; Germany, E. M.; Mayank, A.; Wohlschlegel, J. A.; Casler, J. C.; Rahman, M. A.; Nazarko, T. Y.; Tarsio, M.; Shiota, T.; Lackner, L. L.; Claypool, S. M.; Kane, P. M.; Barrientos, A.; Khalimonchuk, O.
10.1101/2025.01.30.635785 — biochemistry — Posted on 2025-01-30
206 Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria
Ashraf, K. U.; Bunoro-Batista, M.; Ansell, T. B.; Punetha, A.; Rosario-Garrido, S.; Firlar, E.; Kaelber, J. T.; Stansfeld, P. J.; Petrou, V. I.
10.1101/2025.01.29.634835 — biochemistry — Posted on 2025-01-30
207 Structure and function of the EDEM:PDI ERAD checkpoint complex
Hitchman, C. J.; Lia, A.; Chiritoiu, G. N.; Munteanu, C. V. A.; Ortigosa, J.; Ghenea, S.; Savva, C. G.; De Benedictis, M.; Tax, G.; Bayo, Y.; Crescioli, I.; Alonzi, D. L.; Quigley, A.; Modenutti, C. P.; Petrescu, S. M.; Santino, A.; Gooptu, B.; Roversi, P.
10.1101/2025.01.29.635535 — biochemistry — Posted on 2025-01-30
213 Complex exchanges among plasmids and clonal expansion of lineages shape the population structure and virulence of Borrelia burgdorferi
Laing, R. A.; Foster, M. J.; Hassani, M. A.; Kotzen, B.; Huang, W.; Shea, T.; Schaffner, S. F.; Cerar, T.; Freimark, L.; Ruzic-Sabljic, E.; Liveris, D.; Reed, K. D.; Branda, J. A.; Steere, A. C.; Wormser, G. P.; Strle, F.; Sabeti, P. C.; Earl, A.; Schwartz, I.; Strle, K.; Lemieux, J. E.
10.1101/2025.01.29.635312 — microbiology — Posted on 2025-01-30
215 Genetic memory devices to detect specialized metabolites in plant and soil microbiomes
Hansen, M. L.; Kordatos, K. I.; Norgaard, J.-J. K.; Jorgensen, J. P.; Strube, M. L.; Schostag, M. D.; Yang, L.; Jelsbak, L.
10.1101/2025.01.30.635401 — microbiology — Posted on 2025-01-30
218 Mapping of Quorum Sensing Landscape of Commensal and Pathogenic Staphylococci Reveals a Largely Inhibitory Interaction Network
Gless, B. H.; Sereika-Bejder, B. S.; Jensen, I.; Bojer, M. S.; Tsiko, K.; Schmied, S. H.; Vitolo, L.; Toledo-Silva, B.; De Vliegher, S.; Ingmer, H.; Olsen, C. A.
10.1101/2025.01.30.635662 — microbiology — Posted on 2025-01-30
225 The transcription factor Traffic jam orchestrates the somatic piRNA pathway in Drosophila ovaries
Alizada, A.; Martins, A.; Mouniee, N.; Suarez, J. R.; Bertin, B.; Gueguen, N.; Mirouse, V.; Papameletiou, A.-M.; Rivera, A. J.; Lau, N. C.; Akkouche, A.; Mehouas, S. M.; Hannon, G. J.; Nicholson, B. C.; Brasset, E.
10.1101/2024.09.10.612307 — molecular biology — Posted on 2025-01-30
226 Simultaneous, real-time tracking of many neuromodulatory signals with Multiplexed Optical Recording of Sensors on a micro-Endoscope
Kalugin, P. N.; Soden, P. A.; Massengill, C. I.; Amsalem, O.; Porniece, M.; Guarino, D. C.; Tingley, D.; Zhang, S. X.; Benson, J. C.; Hammell, M. F.; Tong, D. M.; Ausfahl, C. D.; Lacey, T. E.; Courtney, Y.; Hochstetler, A.; Lutas, A.; Wang, H.; Geng, L.; Li, G.; Li, B.; Li, Y.; Lehtinen, M. K.; Andermann, M. L.
10.1101/2025.01.26.634931 — neuroscience — Posted on 2025-01-30
228 Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons.
Barrett, A.; Varol, E.; Weinreb, A.; Taylor, S. R.; McWhirter, R.; Cros, C.; Vidal, B.; Basavaraju, M.; Poff, A.; Tipps, J. A.; Majeed, M.; Wang, C.; Bayer, E. A.; Reilly, M.; Yemini, E.; Sun, H.; Hobert, O.; Miller, D. M.; Hammarlund, M.
10.1101/2022.04.05.487209 — genetics — Posted on 2025-01-30
230 Climate change, age acceleration, and the erosion of fitness in polar bears
Newediuk, L.; Richardson, E. S.; Biddlecombe, B. A.; Kassim, H.; Kathan, L.; Lunn, N.; Rivkin, L. R.; Salama, O. E.; Schmidt, C.; Jones, M. J.; Garroway, C. J.
10.1101/2024.01.05.574416 — ecology — Posted on 2025-01-30
231 Signal transduction pathways controlling Ins2 gene activity and β cell state transitions
Chu, J.; Sabbineni, B.; Cen, H. H.; Hu, X.; Sun, W. G.; Brownrigg, G. P.; Xia, Y. H.; Rogalski, J.; Johnson, J. D.
10.1101/2024.06.06.597838 — cell biology — Posted on 2025-01-30
233 Alterations of Task-based fMRI Topology Underlying Cognitive Flexibility and Stability in Schizophrenia
Sundermeier, M.; Standke, I.; Schubotz, R. I.; Dannlowski, U.; Lencer, R.; Mecklenbrauck, F.; Trempler, I.; Zahedi, A.
10.1101/2025.01.30.635673 — neuroscience — Posted on 2025-01-30
235 Aperiodicity in mouse CA1 and DG power spectra
Kühn, G.; Rashidy, H. E.; Calegari, F.; Dhingra, S.
10.1101/2025.01.30.635678 — neuroscience — Posted on 2025-01-30
242 Threshold effects of prenatal stress on striatal microglia and relevant behaviors
Maurer, S. V.; Evans, M. M.; Dukle, M.; Kundu, S.; Dennis, J. L.; Ellerbroek, R. M.; Anema, S. L.; Roshko, V. C.; Stevens, H. E.
10.1101/2025.01.30.635666 — neuroscience — Posted on 2025-01-30
247 Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes
Atser, M. G.; Wenyonu, C. D.; Rowe, E. M.; Leung, C. L. K.; Cen, H. H.; Queathem, E. D.; Liu, L. T.; Moravcova, R.; Rogalski, J.; Perrin, D.; Crawford, P.; Foster, L. J.; Alcazar, A.; Johnson, J. D.
10.1101/2024.10.14.618123 — biochemistry — Posted on 2025-01-30
248 Progress in Developing a Bark Beetle Identification Tool
Marais, G. C.; Stratton, I. C.; Hulcr, J.; Johnson, A. J.
10.1101/2024.09.08.611906 — ecology — Posted on 2025-01-30
252 Predicting Inhibitors of OATP1B1 via Heterogeneous OATP-Ligand Interaction Graph Neural Network (HOLIgraph)
Mardikoraem, M.; Eaves, J. N.; Belecciu, T.; Pascual, N. S.; Aljets, A.; Orlando, B. J.; Shapiro, E. M.; Woldring, D. R.
10.1101/2024.10.01.615464 — bioengineering — Posted on 2025-01-30
253 Cis-nonPro Peptides: Genuine Occurrences and their Functional Roles
Richardson, J. S.; Videau, L. L.; Williams, C. J.; Hintze, B. J.; Lewis, S. M.; Richardson, D. C.
10.1101/324517 — biochemistry — Posted on 2025-01-30
256 Trace metals availability controls terminal electron acceptor utilization in Escherichia coli
Ricciardelli, A.; de Pins, B.; Brusca, J.; Correggia, M.; di Iorio, L.; Cascone, M.; Giardina, M.; Castaldi, S.; Isticato, R.; Iacono, R.; Moracci, M.; Nappi, N.; Pollio, A.; Vetriani, C.; Leone, S.; Cordone, A.; Giovannelli, D.
10.1101/2025.01.08.631794 — microbiology — Posted on 2025-01-30
257 Growth in Low Carbon Conditions Reveals Amino-Acid-Coupled Iron Uptake
Lara-Gutierrez, J.; Nguyen, J.; McIlvin, M. R.; Sugiyama, I.; Landry, Z.; Alcolombri, U.; Keegstra, J. M.; Pontrelli, S.; Jimenez-Martinez, J.; Sauer, U.; Hwa, T.; Saito, M.; Stocker, R.
10.1101/2025.01.15.633289 — microbiology — Posted on 2025-01-30
258 Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2
Subramaniam, S.; Napoleon, M. A.; Lotfollahzadeh, S.; Kamal, M. H.; Kurniawan, H.; Elsadawi, M.; Kenney, D.; Douam, F.; Bosmann, M.; Whelan, S.; Cabral, H.; Burks, E. J.; Zhao, G.; Kolachalama, V.; Ravid, K.; Chitalia, V.
10.1101/2025.01.17.633602 — systems biology — Posted on 2025-01-30
259 Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
Schaepe, J. M.; Fries, T.; Doughty, B. R.; Crocker, O. J.; Hinks, M. M.; Marklund, E.; Greenleaf, W. J.
10.1101/2025.01.27.635162 — biophysics — Posted on 2025-01-30
263 Genome evolution and between-host transmission of Spiroplasma endosymbiont in wild communities of Morpho butterflies
Jonathan, F.; Lopez-Villavicencio, M.; Vincent, D.; Rignault, G.; Rachel, F.; Camilo, S.; Karina, L. S.-B.; Patrick, B.; Andre, V. L. F.; Carolina, P.-D.; Violaine, L.
10.1101/2024.02.22.581604 — evolutionary biology — Posted on 2025-01-30
264 The balanced lethal system in Triturus newts originated in an instantaneous speciation event.
France, J. M.; de Visser, M. C.; Arntzen, J. W.; Babik, W.; Cvijanovic, M.; Ivanovic, A.; Smith, J.; Vuicc, T.; Wielstra, B.
10.1101/2024.10.29.620207 — evolutionary biology — Posted on 2025-01-30
265 Morphology and distribution of a new scale mechanoreceptor type in olive-headed sea snakes (Hydrophis major)
Wagner, A.; Johnson, C.; Myoung, H. H.; Sanders, K. L.; Collin, S. P.; Crowe-Riddell, J. M.
10.1101/2025.01.28.635253 — ecology — Posted on 2025-01-30
266 BubR1 and Mad2 regulate adult midgut remodeling in Drosophila diapause
Adachi, Y.; Nagai, H.; Fujichika, T.; Takahashi, A.; Miura, M.; Nakajima, Y.
10.1101/2025.01.26.634899 — developmental biology — Posted on 2025-01-30
267 Infection and herbicide exposure implicate c-Abl kinase in α-Synuclein Ser129 phosphorylation
Ehsani, M.; Sun, Z.; Quevedo-Olmos, A.; Roesler, G.; Rasa, M.; Holthaus, D.; Erttmann, S. F.; Meyer, T. F.
10.1101/2025.01.29.635561 — neuroscience — Posted on 2025-01-30
268 A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation
Gongwer, M. W.; Qi, A.; Enos, A. S.; Mora, S. A. R.; Klune, C. B.; Shari, M.; Kashay, A.; Williams, O. H.; Hacking, A.; Riley, J. P.; Wilke, G. A.; Yang, Y.; Lu, H.; Leuchter, A. F.; DeNardo, L. A.; Wilke, S. A.
10.1101/2025.01.29.635537 — neuroscience — Posted on 2025-01-30
269 MITF regulates gene expression in middle tufted neurons and other projection neurons of the olfactory bulb
Mechmet, F.; San Jose, A. S.; Sigurdsson, S.; Gautsson, I.; Steingrimsson, E.; Petersen, P.
10.1101/2025.01.29.635553 — neuroscience — Posted on 2025-01-30
270 Dopamine signaling drives skin invasion by human-infective nematodes
Patel, R.; Romero, A. G.; Bryant, A. S.; Agak, G. W.; Hallem, E. A.
10.1101/2025.01.29.635547 — neuroscience — Posted on 2025-01-30
272 Cortical circuits for cross-modal generalization
Guyoton, M.; Matteucci, G.; Foucher, C. G.; Getz, M. P.; Gjorgjieva, J.; El-Boustani, S.
10.1101/2023.10.13.562215 — neuroscience — Posted on 2025-01-30
273 The density of doublecortin cells in the piriform cortex is affected by transition to adulthood but not first pregnancy in female mice
Esteve-Perez, R.; Abellan-Alvaro, M.; Navarro-Moreno, C.; Prina, M.; Barneo-Munoz, M.; Lanuza, E.; Sanchez-Catalan, M. J.; Martinez-Garcia, F.; Torres-Perez, J. V.; Agustin-Pavon, C.
10.1101/2023.02.08.527694 — neuroscience — Posted on 2025-01-30
274 Aggregated α-synuclein leads to corticostriatal synaptic dysfunction
Brzozowski, C.; Challa, H.; Gcwensa, N. Z.; Hall, D.; Nabert, D.; Chambers, N. E.; Gallardo, I.; Millett, M. F.; Volpicelli-Daley, L.; Moehle, M.
10.1101/2025.01.29.635597 — neuroscience — Posted on 2025-01-30
275 Tiny radio-tag backpacks impact, but do not significantly affect, hummingbird time budgets in captivity
Sargent, A. J.; Fernandes, A. M.; Clarkson, A. E.; Martinez, S.-L.; Coenen, A.; Hansell, L.; Talwekar, Y.; Munoz Amaya, M. A.; Tellez Colmenares, N.; Elting, R.; Sun, Y.; Cartwright, O. A.; Büttner, N.; Rico-Guevara, A.
10.1101/2025.01.29.635563 — animal behavior and cognition — Posted on 2025-01-30
279 The selective culture and enrichment of major rumen bacteria on three distinct anaerobic culture media
Buckner, A. M.; Glendinning, L.; Palma Hidalgo, J. M.; van Munster, J. M.; Stevens, M.; Watson, M.; Newbold, C. J.
10.1101/2024.08.23.608987 — microbiology — Posted on 2025-01-30
281 Deep-learning based Embedding of Functional Connectivity Profiles for Precision Functional Mapping
Tu, J.; Kim, J.-H.; Luckett, P. H.; Adeyemo, B.; Shimony, J. S.; Elison, J. T.; Eggebrecht, A. T.; Wheelock, M. D.
10.1101/2025.01.29.635570 — neuroscience — Posted on 2025-01-30
284 KaMLs for Predicting Protein pKa Values and Ionization States: Are Trees All You Need?
Shen, M.; Kortzak, D.; Ambrozak, S.; Bhatnagar, S.; Buchanan, I.; Liu, R.; Shen, J.
10.1101/2024.11.09.622800 — biophysics — Posted on 2025-01-30
286 Indian Wellderly exomes underscore NRAP roles in elderly hypertrophic cardiomyopathy
Chimata, P.; Ankit, S.; Agrawal, R.; Rao, V. J.; Koranchery, R.; Rajendran, R.; Mohanan, K. S.; Shenthar, J.; Bazrafshan, S.; Sadayappan, S.; Ahamed, H.; Dhandapany, P. S.
10.1101/789065 — genomics — Posted on 2025-01-30
288 Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction
Bu, X.; Ashby, N.; Vitali, T.; Lee, S.; Gottumukkala, A.; Yoon, K.; Tabbara, S.; Latham, P.; Teal, C.; Chung, I.
10.1101/2024.07.05.602223 — cell biology — Posted on 2025-01-30
289 IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming
Li, M.; Zhang, H.; Wu, X.; Yu, M.; Yang, Q.; Sun, L.; Li, W.; Jiang, Z.; Xue, F.; Wang, T.; An, X.; Chen, L.
10.1101/2024.06.18.599556 — cell biology — Posted on 2025-01-30
290 Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans
Pant, R.; Pitchaimuthu, K.; Ossandon, J. P.; Shareef, I.; Lingareddy, S.; Finsterbusch, J.; Kekunnaya, R.; Röder, B.
10.1101/2024.04.18.590147 — neuroscience — Posted on 2025-01-30
291 Exon inclusion signatures enable accurate estimation of splicing factor activity
Anglada-Girotto, M.; Moakley, D. F.; Zhang, C.; Miravet-Verde, S.; Califano, A.; Serrano, L.
10.1101/2024.06.21.600051 — systems biology — Posted on 2025-01-30
292 Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL
Liu, Y.; Jiang, H.; Liu, J.; Stuani, L.; Merchant, M.; Jager, A.; Koladiya, A.; Chang, T.-C.; Domizi, P.; Sarno, J.; Keyes, T.; Jedoui, D.; Wang, A.; Meng, J.; Hartmann, F.; Bendall, S. C.; Huang, M.; Lacayo, N. J.; Sakamoto, K. M.; Mullighan, C. G.; Mignon, L.; Yu, J.; Yang, J. J.; Ye, J.; Davis, K. L.
10.1101/2025.01.27.635108 — cancer biology — Posted on 2025-01-30
293 Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
Schaepe, J. M.; Fries, T.; Doughty, B. R.; Crocker, O. J.; Hinks, M. M.; Marklund, E.; Greenleaf, W. J.
10.1101/2025.01.27.635162 — biophysics — Posted on 2025-01-30
294 Tension-induced suppression of allosteric conformational changes explains coordinated stepping of kinesin-1
Makino, T.; Kanada, R.; Mori, T.; Miyazono, K.-i.; Komori, Y.; Yanagisawa, H.; Takada, S.; Tanokura, M.; Kikkawa, M.; Tomishige, M.
10.1101/2024.09.19.613825 — biophysics — Posted on 2025-01-30
296 ScaleSC: A superfast and scalable single cell RNA-seq data analysis pipeline powered by GPU.
Hu, W.; Zhang, H.; Gagnon, J.; Ouyang, z.; Moroishi, Y.; Sun, Y.; Cao, S.; Zhang, B.
10.1101/2025.01.28.635256 — bioinformatics — Posted on 2025-01-30
297 ParaSurf: A Surface-Based Deep Learning Approach for Paratope-Antigen Interaction Prediction
Papadopoulos, A. M.; Axenopoulos, A.; Iatrou, A.; Stamatopoulos, K.; Alvarez, F.; Daras, P.
10.1101/2024.12.16.628621 — bioinformatics — Posted on 2025-01-30
298 The coiled-coil domain of myosin-11 as a potential biomarker to detect patients with atherosclerotic cardiovascular disease risk
Takahashi, L.; Tomiyama, H.; Kobori, H.; Hidaka, Y.; Orihara, S.; Satomi, K.; Taguri, M.; Chikamori, T.; Yokoyama, U.
10.1101/2025.01.28.635387 — biochemistry — Posted on 2025-01-30
302 Single-cell transcriptomics reveals the impact of sex and age in the healthy human liver
Rahman, R.; Epstein, E. T.; Murphy, S.; Amir-Zilberstein, L.; McCabe, C.; Delorey, T.; Koene, H.; Fernandes, L.; Tanabe, K. K.; Qadan, M.; Ferrone, C.; Berger, D. L.; Shih, A.; Deguine, J.; Mullen, A.
10.1101/2025.01.27.635138 — cell biology — Posted on 2025-01-30
303 Transmissible antimicrobial resistance in Escherichia coli isolated from household drinking water in Ibadan, Nigeria
Rabiu, A. G.; Dada, R. A.; Afolayan, A. O.; Akinlabi, O. C.; Akande, E. T.; Falodun, O. I.; Okeke, I. N.
10.1101/2025.01.28.635236 — microbiology — Posted on 2025-01-30
308 Inference of human pigmentation from ancient DNA by genotype likelihood
Perretti, S.; Vizzari, M. T.; Santos, P.; Tassani, E.; Benazzo, A.; Ghirotto, S.; Barbujani, G.
10.1101/2025.01.29.635495 — genomics — Posted on 2025-01-30
309 The heritability of migration behaviours in a wide-ranging ungulate
Bonar, M.; Wootton, E.; Anderson, C. R.; Wittemyer, G.; Northrup, J. M.; Shafer, A.
10.1101/2025.01.28.635302 — genetics — Posted on 2025-01-29
311 PP6 phosphatase and Elongator contribute to kinesin 5-dependent spindle assembly by controlling microtubule regulator levels
Marin, L.; Castro-Sangrador, J.; Hoya, M.; Tello, S.; Coll, P. M.; Encinar del Dedo, J.; Fernandez-Alvarez, A.; Ribas, J. C.; Tran, P. T.; Rincon, S. A.
10.1101/2025.01.29.635436 — cell biology — Posted on 2025-01-29
313 Divergent Effects of APOE3 and APOE4 Human Astrocytes on Key Alzheimer's Disease Hallmarks in Chimeric Mice
Cruz-Sese, J.; Miron-Alcala, M.; Alfonso-Triguero, M.; Olalde, J.; Ruiz, L.; Galbis-Gramage, N.; Cortes, L.; Escobar, L.; Preman, P.; Snellinx, A.; Saito, T.; Saido, T. C.; Saiz-Auz, L.; Rabano-Gutierrez, A.; TCW, J.; Goate, A. M.; De Strooper, B.; Alberdi, E.; Arranz, A. M.
10.1101/2025.01.28.635271 — neuroscience — Posted on 2025-01-29
314 Identifying and treating CLN3 disease outside the central nervous system
Ziolkowska, E. A.; Jablonka, A.; Williams, L. L.; Jansen, M. J.; Eultgen, E. M.; Wood, M. D.; Hunter, D. A.; Sharma, J.; Sardiello, M.; Sax, S. E.; Bradley, R. P.; Whiteman, I. T.; Reese, R.; Pestronk, A.; Sands, M. S.; Heuckeroth, R. O.; Snyder-Warwick, A. K.; Cooper, J. D.
10.1101/2025.01.29.635518 — neuroscience — Posted on 2025-01-29
319 Structural insights into transcriptional regulation by the helicase RECQL5
Ariza, A. J. F.; Lue, N. Z.; Grob, P.; Kaeser, B.; Fang, J.; Kassube, S. A.; Nogales, E.
10.1101/2025.01.29.634372 — molecular biology — Posted on 2025-01-29
324 Decoding sequence determinants of gene expression in diverse cellular and disease states
Lal, A.; Karollus, A.; Gunsalus, L.; Garfield, D.; Nair, S.; Tseng, A. M.; Gordon, M. G.; Blischak, J. D.; Van de Geijn, B.; Bhangale, T.; Collier, J. L.; Diamant, N.; Biancalani, T.; Corrada Bravo, H.; Scalia, G.; Eraslan, G.
10.1101/2024.10.09.617507 — genomics — Posted on 2025-01-29
325 Study design and the sampling of deleterious rare variants in biobank-scale datasets
Steiner, M. C.; Rice, D. P.; Biddanda, A.; Ianni-Ravn, M. K.; Porras, C.; Novembre, J.
10.1101/2024.12.02.626424 — genetics — Posted on 2025-01-29
326 Strong genetic differentiation but limited niche partitioning in a sympatric species pair separated by an allochronic reproductive barrier
Irvine, M.; Stewart, Z.; Kumaran, N.; Manawaduge, C. G.; Ryan, J. L.; Balagawi, S.; Missenden, B.; Starkie, M.; Clarke, A. R.; Hurwood, D. A.; Prentis, P.
10.1101/2023.08.30.555036 — evolutionary biology — Posted on 2025-01-29
327 Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne Muscular Dystrophy
Novak, J. S.; Lischin, A.; Uapinyoying, P.; Hindupur, R.; Moon, Y. J.; Bhattacharya, S.; Tiufekchiev, S.; Barone, V.; Mazala, D. A.; Gamu, I. H.; Walters, G.; Jaiswal, J. K.
10.1101/2024.08.15.607998 — cell biology — Posted on 2025-01-29
329 Single-cell transcriptional profiling reveals a novel RAB13+ endothelial subpopulation and profibrotic mesenchymal cells in the aged human bone marrow
Cenzano, I.; Cocera, M.; Lopez Perez, A. R.; Campos-Dopazo, L.; Ruiz, J.; Sancho, I.; San Martin-Uriz, P.; Sarvide, S.; Aguirre-Ruiz, P.; Vilas-Zornoza, A.; Ripalda-Cemborain, P.; Alignani, D.; Lopez, A.; Minana Barrios, M.; Quilez Agreda, D.; Ye, J.; Lehmann, R.; Sudupe, L.; Abengozar-Muela, M.; Tamariz-Amador, L.-E.; MUINOS-LOPEZ, E.; Saez, B.; Tegner, J.; A. Calvo, I.; Gomez-Cabrero, D.; Prosper, F.
10.1101/2025.01.28.635238 — molecular biology — Posted on 2025-01-29
331 The T3SS structural and effector genes of Chlamydia trachomatis are expressed in distinct phenotypic cell forms.
Grieshaber, N.; Appa, C. R.; Ward, M.; Grossman, A.; McCormik, S.; Grieshaber, B. S.; Chiarelli, T. J.; Yang, H.; Omsland, A.; Grieshaber, S. S.
10.1101/2024.04.25.591156 — microbiology — Posted on 2025-01-29
333 RNA modifications on Adenosine co-Regulate Macrophage Function
Griesche, V.; Di Giorgio, S.; Tellioglu, I.; Kao, C.-Y.; Lorenzo, J. P.; Pezzella, L.; Brettschneider, J.; Stoecklin, G.; Papavasiliou, F. N.
10.1101/2025.01.28.635339 — immunology — Posted on 2025-01-29
334 A Bi-Specific T Cell-Engaging Antibody Shows Potent Activity, Specificity, and Tumor Microenvironment Remodeling in Experimental Syngeneic and Genetically Engineered Models of GBM
Zannikou, M. Z.; Duffy, J. T.; Procissi, D.; Najem, H.; Levine, R. N.; Hambardzumyan, D.; Lee-Chang, C.; Leoni, L.; Zhang, B.; Heimberger, A. B.; Miska, J.; Balyasnikova, I. V.
10.1101/2024.12.18.628714 — immunology — Posted on 2025-01-29
336 The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity
Witt, K. C.; Dziulko, A.; An, J.; Pekovic, F.; Cheng, A. X.; Liu, G. Y.; Lee, O. V.; Turner, D. J.; Lari, A. C.; Gaidt, M. M.; Chavez, R.; Fattinger, S. A.; Abraham, P.; Dhaliwal, H.; Lee, A. Y.; Kotov, D. I.; Coscoy, L.; Glaunsinger, B.; Valkov, E.; Chuong, E. B.; Vance, R. E.
10.1101/2024.08.28.610186 — immunology — Posted on 2025-01-29
338 Anchoring functional connectivity to individual sulcal morphology yields insights in a pediatric study of reasoning
Hakkinen, S.; Voorhies, W. I.; Willbrand, E.; Tsai, Y.-H.; Gagnant, T.; Yao, J. K.; Weiner, K. S.; Bunge, S.
10.1101/2024.04.18.590165 — neuroscience — Posted on 2025-01-29
340 Behavioral and genetic markers of susceptibility to escalate fentanyl intake.
Keady, J.; Charnigo, R.; Shaykin, J. D.; Prantzalos, E. R.; Xia, M.; Denehy, E.; Bumgardner, C.; Miller, J.; Ortinski, P.; Bardo, M.; Turner, J. R.
10.1101/2024.12.06.627259 — neuroscience — Posted on 2025-01-29
342 Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair
Phelps, P. E.; Ha, S. M.; Khankan, R. R.; Mekonnen, M. A.; Juarez, G.; Ingraham Dixie, K. L.; Chen, Y.-W.; Yang, X.
10.1101/2023.12.20.572462 — neuroscience — Posted on 2025-01-29
347 Multiplex, multimodal mapping of variant effects in secreted proteins
Popp, N. A.; Powell, R. L.; Wheelock, M. K.; Holmes, K. J.; Zapp, B. D.; Sheldon, K. M.; Fletcher, S. N.; Wu, X.; Fayer, S.; Rubin, A. F.; Lannert, K. W.; Chang, A. T.; Sheehan, J. P.; Johnsen, J. M.; Fowler, D. M.
10.1101/2024.04.01.587474 — genomics — Posted on 2025-01-29
348 Platelet mitochondrial transfer via extracellular vesicles modulates neutrophil phenotype and function
Allan, H. E.; Dark, N.; Vulliamy, P.; Crescente, M.; Armstrong, P. C.; Ferreira, P.; Warner, T. D.
10.1101/2025.01.29.635414 — cell biology — Posted on 2025-01-29
349 Chromosome Pairing Through Tensed DNA Tethers Model Revealed by BRCA2 Meiotic Domain Deletion
Koornneef, L.; van Rossum-Fikkert, S. E.; Sleddens-Linkels, E.; Miron, S.; Maas, A.; van Loon, Y.; Barchi, M.; Zinn-Justin, S.; Essers, J.; Kanaar, R.; Baarends, W. M.; Zelensky, A. N.
10.1101/2023.10.06.561239 — molecular biology — Posted on 2025-01-29
351 Cortical circuits for cross-modal generalization
Guyoton, M.; Matteucci, G.; Foucher, C. G.; Getz, M. P.; Gjorgjieva, J.; El-Boustani, S.
10.1101/2023.10.13.562215 — neuroscience — Posted on 2025-01-29
355 The first complete 3D reconstruction and morphofunctional mapping of an insect eye
Makarova, A. A.; Chua, N. J.; Diakova, A. V.; Desyatirkina, I. A.; Gunn, P.; Pang, S.; Xu, C. S.; Hess, H. F.; Chklovskii, D. B.; Polilov, A. A.
10.1101/2024.09.30.615804 — zoology — Posted on 2025-01-29
358 A generic reference defined by consensus peaks for scATAC-seq data analysis
Meng, Q.; Wu, X.; Chen, W.; Zhao, Y.; Li, C.; Wei, Z.; Li, J.; Xi, X.; Chen, S.; Zhang, C.; Chen, S.; Li, J.; Wang, X.; Jiang, R.; Wei, L.; Zhang, X.
10.1101/2023.05.30.542889 — bioinformatics — Posted on 2025-01-29
360 HIV Coreceptors Related Genes (CCR5 and CXCR4) Promoter Methylation: Original Research
Esman, A.; Salamaikina, S.; Kirichenko, A.; Vinokurov, M.; Fomina, D.; Sikamov, K.; Syrkina, A.; Pokrovskaya, A.; Akimkin, V.
10.1101/2024.07.01.601546 — genetics — Posted on 2025-01-29
361 Chromosome X Dosage Modulates Development of Aneuploidy in Genetically Diverse Mouse Embryonic Stem Cells
Stanton, A.; Aydin, S.; Skelly, D. A.; Stavish, D.; Leonhard, K. A.; McIntire, E.; Pankratz, M.; Czechanski, A.; Ludwig, T.; Choi, T.; Gygi, S. P.; Barbaric, I.; Munger, S. C.; Reinholdt, L. G.; PERA, M. F.
10.1101/2024.06.29.601344 — genetics — Posted on 2025-01-29
362 An unexplored diversity for adaptation of germination to high temperatures in Brassica species
Tiret, M.; Wagner, M.-H.; Gay, L.; Chenel, E.; Dupont, A.; Falentin, C.; Gavory, F.; Labadie, K.; Ducournau, S.; Chevre, A.-M.
10.1101/2024.10.22.619588 — evolutionary biology — Posted on 2025-01-29
363 Pathophysiological Significance of Impaired KAT7-Dependent Histone H3K14 Acetylation During Zinc Deficiency
Fujisawa, T.; Takenaka, S.; Maekawa, L.; Kowada, T.; Matsui, T.; Mizukami, S.; Kato, Y.; Suzuki, M.; Noma, H.; Naguro, I.; Ichijo, H.
10.1101/2023.10.18.562865 — cell biology — Posted on 2025-01-29
364 Characterization of a virulent bacteriophage consortium targeting Enterobacteriaceae from inflamed preterm gut mucosa
Spiegelhauer, M. R.; Offersen, S. M.; Krych, L.; Nielsen, D. S.; Gambino, M.; Brunse, A.; Nguyen, D. N.
10.1101/2025.01.29.635513 — microbiology — Posted on 2025-01-29
365 Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology
Rodriguez-Rodriguez, P.; Wang, W.; Tsagkogianni, C.; Feng, I.; Morello-Megias, A.; Jain, K.; Alanko, V.; Kahvecioglu, H.; Mohammadi, E.; Li, X.; Flajolet, M.; Sandebring-Matton, A.; Maioli, S.; Vidal, N.; Milosevic, A.; Roussarie, J.-P.
10.1101/2024.12.31.630881 — neuroscience — Posted on 2025-01-29
367 Unprecedented Cytotoxicity of Transition Metal Metallacarboranes on Triple Negative Breast Cancer Cells and a Vertebrate Cancer Model
Farras, P.; Murphy, N.; Tipping, W. J.; Ding, Y.; Dwyer, R. M.; Faulds, K.; Pandit, A.; Graham, D.; Spaink, H. P.
10.1101/2025.01.29.635527 — biochemistry — Posted on 2025-01-29
368 Acquisition of ampliconic sequences marks a selfish mouse t-haplotype
Swanepoel, C.; Wang, G.; Zhang, L.; Braendl, B.; Bauer, H.; Tsaytler, P.; Muller, F.-J.; Herrmann, B.; Mueller, J. L.
10.1101/2025.01.28.635315 — genetics — Posted on 2025-01-29
371 Conformational and Functional Regulation of SET by Legumain Cleavage
Horak, C.; Wieland, A. C.; Klaushofer, R.; Briza, P.; Brandstetter, H.; Dall, E.
10.1101/2025.01.28.635311 — molecular biology — Posted on 2025-01-29
373 An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening
Matosevich, N.; Regev, N.; Kimchy, E.; Zelinger, N.; Kabaha, S.; Gabay, N.; Marmelshtein, A.; Nir, Y.
10.1101/2025.01.29.635485 — neuroscience — Posted on 2025-01-29
375 Customizing the Structure of a Minimal TIM Barrel to Craft a De Novo Enzyme
Beck, J.; Smith, B. J.; Zarifi, N.; Freund, E.; Chica, R. A.; Hoecker, B.
10.1101/2025.01.28.635154 — biochemistry — Posted on 2025-01-29
376 DMB labelling for detection and analysis of capsular polysaccharides
Rutschmann, C.; Vershynina, K.; Mathew, C.; Piech, L.; Sulewska, M.; Schilling, P. E.; Wenner, N.; Larsson, L.; Bertola, A.; Cappio Barazzone, E.; Domocos, I.; Roese Mores, C.; Raisse Ndem-Galbert, J.; Turgay, Y.; Schumann, R.; de Viragh, S.; Lavender, H.; Tang, C.; Diard, M.; Sunagawa, S.; Wetter, M.; Fiebig, T.; Slack, E.; Keys, T. G.
10.1101/2025.01.29.635457 — biochemistry — Posted on 2025-01-29
377 Interface integrity in septin protofilaments is maintained by an arginine residue conserved from yeast to man.
Grupp, B.; Graser, J. B.; Seifermann, J.; Gerhardt, S.; Lemkul, J. A.; Gehrke, J. F.; Johnsson, N.; Gronemeyer, T.
10.1101/2025.01.29.635471 — biochemistry — Posted on 2025-01-29
384 Obligate cross-feeding of metabolites is common in soil microbial communities
Yousif, G.; Zorrilla, F.; Dash, S.; Ona, L.; Shekhar, A.; Giri, S.; Guan, R.; Harshe, S.; Itermann, M.; Welter, D.; Benes, V.; Patil, K. R.; Kost, C.
10.1101/2025.01.29.635426 — microbiology — Posted on 2025-01-29
388 Lethal streptococcal infection is associated with widened lymph node bottlenecks
Xia, L.; Hullahalli, K.; Tian, X.; Yuan, C.; Pan, F.; Fan, H.; Waldor, M. K.; Ma, Z.
10.1101/2025.01.29.635438 — microbiology — Posted on 2025-01-29
389 Capturing dynamic phage-pathogen coevolution by clinical surveillance
Mathur, Y.; Boyd, C.; Farnham, J.; MONIR, M. M.; Islam, M. T.; Sultana, M.; Ahmed, T.; Alam, M.; Seed, K.
10.1101/2025.01.29.635557 — microbiology — Posted on 2025-01-29
390 Molecular mechanisms of plastic biodegradation by the fungus Clonostachys rosea
Gambarini, V.; Pavlov, N.; Young, P. G.; Dawes, S.; Auffret, A.; Kingsbury, J. M.; Donaldson, L. A.; Smith, D. A.; Weaver, L.; Pantos, O.; Handley, K. M.; Lear, G.
10.1101/2025.01.28.635403 — microbiology — Posted on 2025-01-29
396 CPSF6 Promotes HIV-1 Preintegration Complex Function
Chaudhuri, E.; Jang, S.; Chakraborty, R.; Radhakrishnan, R.; Arnarson, B.; Prakash, P.; Cornish, D.; Rohlfes, N.; Singh, P. K.; Shi, J.; Aiken, C.; Campbell, E. M.; Hultquist, J. F.; Engelman, A.; Balasubramaniam, M.; Dash, C.
10.1101/2025.01.28.635394 — biochemistry — Posted on 2025-01-29
401 Autocrine glucocorticoid signaling in hormonally active cancer induces antigen expression for immunotherapy
Schauer, M. P.; Weber, J.; Spieler, P.; Altieri, B.; Gehrke, L.; Sbiera, S.; Kircher, S.; Kurlbaum, M.; Kroiss, M.; Kiseljak-Vassiliades, K.; Wierman, M.; Nerreter, T.; Einsele, H.; Fassnacht, M.; Landwehr, L.-S.; Hudecek, M.
10.1101/2025.01.28.632923 — cancer biology — Posted on 2025-01-29
404 Divergent morphologies with convergent performance in the mandible of pelagiarian fishes
Knapp, A.; Rangel-de Lazaro, G.; Friedman, M.; Johanson, Z.; Evans, K.; Giles, S.; Beckett, H.; Goswami, A.
10.1101/2025.01.28.634496 — evolutionary biology — Posted on 2025-01-29
405 Climatic niche conservatism in non-native plants depends on introduction history and biogeographic context
Rönnfeldt, A.; Holle, V.; Schifferle, K.; Gallien, L.; Knight, T.; Weigelt, P.; Craven, D.; Cabral, J. S.; Zurell, D.
10.1101/2025.01.28.635214 — ecology — Posted on 2025-01-29
407 Decoding Phenotypic Variability in Osteogenesis Imperfecta: Zebrafish as a Model for Molecular and Ultrastructural Insights.
Debaenst, S.; Sahd, L.; Debaene, C.; Jarayseh, T.; De Saffel, H.; Bek, J. W.; Steyaert, W.; Van Haver, D.; Dufour, S.; Impens, F.; Coucke, P.; De Clercq, A.; Willaert, A.
10.1101/2025.01.28.635270 — molecular biology — Posted on 2025-01-29
409 Electrophysiological and network dynamics disruption of hippocampal CA1 neurons after NMDAr blockade by MK-801
Aba-Perez, P.; Molina-Paya, F. J.; Rigamonti, G.; Cabrales, G.; Tirado-Zafra, M.; Falco, A.; Martinez-Otero, L.; Borrell, V.; Sanchez-Mut, J.; Redondo, R.; Brotons-Mas, J. R.
10.1101/2025.01.28.635254 — neuroscience — Posted on 2025-01-29
414 Capturing Nematic Order on Tissue Surfaces of Arbitrary Geometry
Eckert, J.; Andrews, T. G.; Pollard, J.; Priya, R.; Yap, A. S.; Morris, R. G.
10.1101/2025.01.28.635015 — biophysics — Posted on 2025-01-29
417 Improving wearable-based seizure prediction by feature fusion using growing network
Hasija, T.; Kuschel, M.; Jackson, M.; Dailey, S.; Menne, H.; Reinsberger, C.; Vieluf, S.; Loddenkemper, T.
10.1101/2025.01.28.635212 — bioinformatics — Posted on 2025-01-29
419 Statistical crystallography reveals an allosteric network in SARS-CoV-2 Mpro
Creon, A.; Scheer, E.; Reinke, P. Y. A.; Mashhour, A. R.; Guenther, S.; Niebling, S.; Schamoni-Kast, K.; Uetrecht, C.; Meents, A.; Chapman, H. N.; Sprenger, J.; Lane, T. J.
10.1101/2025.01.28.635305 — biochemistry — Posted on 2025-01-29
420 Heartbeat-like dynamics drives oxygen activation in methane monooxygenase
Hwang, Y.; Ryu, B.; Lee, D.-H.; Hong, H. J.; Na, J.-G.; Song, C. G.; Kang, H. G.; Pozharski, E.; Lee, S. J.
10.1101/2025.01.28.635075 — biochemistry — Posted on 2025-01-29
422 Hydrological Connectivity Enhances Fish Biodiversity in Amazonian Mining Ponds: Insights from eDNA and Traditional Sampling
Timana-Mendoza, C.; Reyes-Calderon, A.; Venail, P.; Britzke, R.; Santa-Maria, M. C.; Araujo-Flores, J. M.; Silman, M. R.; Fernandez, L. E.
10.1101/2025.01.28.635072 — ecology — Posted on 2025-01-29
423 Human cerebral organoids model tumor infiltration and migration supported by astrocytes in an autologous setting
Schickel, E.; Bender, T.; Kaysan, L.; Hufgard, S.; Mayer, M.; Grosshans, D. R.; Thielemann, C.; Schroeder, I. S.
10.1101/2025.01.29.635456 — cell biology — Posted on 2025-01-29
424 Visualizing sub-organellar lipid distribution using correlative light and electron microscopy
Lennartz, H. M.; Khan, S.; Böhlig, K.; Leng, W.; Elsner, F.; Scher, N.; Wilsch-Bräuninger, M.; Avinoam, O.; Nadler, A.
10.1101/2025.01.28.635245 — cell biology — Posted on 2025-01-29
425 An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Meniere disease
Harhai, M.; Foged, M. M.; Recazens, E.; Lisci, M.; Chollet, S.; Landoni, J. C.; Laban, N.; Manley, S.; Lopez-Escamez, J. A.; Lysakowski, A.; Jourdain, A. A.
10.1101/2025.01.29.635272 — cell biology — Posted on 2025-01-29
428 RNA promotes synapsin coacervation and modulates local translation
Rankovic, B.; Geisterfer, Z.; Chhabra, A.; Jovanovic, V.; Seim, I.; Hoffmann, C.; Condric, A.; Aguilar Perez, G.; Freitag, K.; Nowick, K.; Jendrach, M.; Heppner, F. L.; Reshetniak, S.; Gladfelter, A.; Milovanovic, D.
10.1101/2025.01.29.635107 — cell biology — Posted on 2025-01-29
430 Histone Variant H2A.Z Cooperates with EBNA1 to Maintain Epstein-Barr Virus Latent Epigenome
Castro-Munoz, J. L.; Maestri, D.; Yoon, L.; Karisetty, B. C.; Tempera, I.; Lieberman, P. M.
10.1101/2025.01.28.635203 — molecular biology — Posted on 2025-01-29
431 Targeting deubiquitinating enzymes (DUBs) and ubiquitin pathway modulators to enhance host defense against bacterial infections
Santelices, J.; Schultz, A. C.; Walker, A.; Adams, N.; Tirado, D.; Barker, H.; Eshraghi, A.; Czyz, D. M.; Ferraro, M. J.
10.1101/2025.01.27.635188 — microbiology — Posted on 2025-01-29
433 Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus
Sasaki, T.; Sowerby, J.; Xiao, Y.; Wang, R.; Marks, K. E.; Horisberger, A.; Gao, Y.; Lee, P. Y.; Qu, Y.; Sze, M. A.; Alves, S. E.; Levesque, M. C.; Fujio, K.; Costenbader, K. H.; Rao, D. A.
10.1101/2025.01.27.635189 — immunology — Posted on 2025-01-29
434 Mitochondrial dysfunction underlies monocyte immune deficiency in patients with severe alcohol-related hepatitis
Middleton, P. K.; Aramayo, R. J.; Montoya, A.; Shliaha, P. V.; Pope, S.; Fets, L.; Vergis, N.; Thursz, M. R.; Cocheme, H. M.
10.1101/2025.01.28.634915 — immunology — Posted on 2025-01-29
435 Drug treatment alters performance in a neural microphysiological system of information processing
Watmuff, B.; Habibollahi, F.; Desouza, C.; Khajehnejad, M.; Loeffler, A.; Baranes, K.; Poulin, N.; Kotter, M.; Kagan, B.
10.1101/2025.01.27.635163 — neuroscience — Posted on 2025-01-29
442 Loss of tumor cell MHC Class II drives insensitivity of BRAF-mutant anaplastic thyroid cancers to MAPK inhibitors
Tiedje, V.; Greenberg, J.; Qin, T.; Im, S.-Y.; Krishnamoorthy, G. P.; Boucai, L.; Xu, B.; French, J. D.; Sherman, E. J.; Ho, A. L.; De Stanchina, E.; Socci, N. D.; Jin, J.; Ghossein, R.; Knauf, J. A.; Koche, R. P.; Fagin, J. A.
10.1101/2025.01.27.635086 — cancer biology — Posted on 2025-01-29
445 Biophysical Basis of the in vivo Electroretinogram of the Mouse: 4-Shell Current Source Density Model
Peinado Allina, G.; Meleppat, R. K.; Yao, V.; Calkins, D. J.; FitzGerald, P.; Schiesser, W. E.; Pugh, E. N.
10.1101/2025.01.28.635195 — biophysics — Posted on 2025-01-29
448 Systematic identification of context-dependent gene essentiality in Glioblastoma: The GBM-CoDE platform
Foster, M. T.; Ewing, A.; Frame, M. C. T.; Brennan, P. M.; Khamseh, A.; Beentjes, S. V.; Carragher, N. O.; Semple, C. A.
10.1101/2025.01.27.634260 — bioinformatics — Posted on 2025-01-29
450 DeepSynBa: Actionable Drug Combination Prediction with Complete Dose-Response Profiles
Kuru, H. I.; Zhang, H.; Rattray, M.; Ek, C. H.; Cicek, A. E.; Tastan, O.; Milo, M.
10.1101/2025.01.28.634673 — bioinformatics — Posted on 2025-01-29
452 mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite generates a local immunostimulatory niche for cancer immunotherapy
Zhu, Y.; Yao, Z.-C.; Li, S.; Ma, J.; Wei, C.; Yu, D.; Stelzel, J. L.; Ni, B. Y. X.; Miao, Y.; Van Batavia, K.; Lu, X.; Lin, J.; Dai, Y.; Kong, J.; Shen, R.; Goodier, K. D.; Liu, X.; Cheng, L.; Vuong, I.; Howard, G. P.; Livingston, N. K.; Choy, J.; Schneck, J. P.; Doloff, J. C.; Reddy, S. K.; Hickey, J. W.; Mao, H.-Q.
10.1101/2025.01.27.633179 — bioengineering — Posted on 2025-01-29
453 Hypoxia modulates human pulmonary arterial adventitial fibroblast phenotype through HIF-1α activation
Philip, J. L.; Caneba, C. A.; Caggiano, L. R.; Prakash, N.; Cheng, T.-C.; Barlow, K. A.; Mustafa, T.; Tabima, D. M.; Hacker, T. A.; Masters, K. S.; Chelser, N. C.
10.1101/2025.01.27.635152 — bioengineering — Posted on 2025-01-29
457 The 3D genomics of lampbrush chromosomes highlights the role of active transcription in chromatin organization
Lagunov, T.; Gridina, M.; Nurislamov, A.; Kulikova, T.; Maslova, A.; Konstantinov, V.; Popov, A.; Krasikova, A.; Fishman, V.
10.1101/2025.01.27.635017 — genomics — Posted on 2025-01-29
461 Data-Driven Feed Optimization for Sustainable Aquaculture through Integrated Omics Analysis and Two-stage Bayesian optimization
Terayama, K.; Soma, S.; Furuita, H.; Shimizu, T.; Iwasaki, T.; Sakata, K.; Akagi, K.-i.; Asakura, T.; Sanda, T.; Tomofumi, Y.; Fujikura, Y.; Hongo, Y.; Shima, H.; Yokota, H.; Kikuchi, J.; Yasuike, M.; Mekuchi, M.
10.1101/2025.01.27.635187 — ecology — Posted on 2025-01-29
463 The shortest telomere in telomerase-negative cells triggers replicative senescence at a critical threshold length and also fuels genomic instability
Berardi, P.; Martinez Fernandez, V.; Rat, A.; Rosas Bringas, F. R.; Jolivet, P.; Langston, R.; Mattarocci, S.; Maes, A.; Aspert, T.; Zeinoun, B.; Casier, K.; Kazemier, H. G.; Charvin, G.; Doumic, M.; Chang, M.; Teixeira, M. T.
10.1101/2025.01.27.635053 — molecular biology — Posted on 2025-01-29
464 RIG-I Stimulation Enhances Effector Function and Proliferation of Primary Human CD8 T Cells
Mohamed, A. A.; Wallerath, C.; Hunkler, C.; Hartmann, G.; Stankovic, S.; Brooks, A.; Schlee, M.
10.1101/2025.01.27.635030 — immunology — Posted on 2025-01-29
467 Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis
Stier, M. T.; Sewell, A. E.; Mwizerwa, E. L.; Sim, C. Y.; Tanner, S. M.; Nichols, C. M.; Durai, H. H.; Jennings, E. Q.; Lindau, P.; Wilfong, E. M.; Newcomb, D. C.; Bastarache, J. A.; Ware, L. B.; Rathmell, J. C.
10.1101/2025.01.27.635146 — immunology — Posted on 2025-01-29
468 A CD57+ cytotoxic CD8 T cell subset associated with fibrotic lung disease in systemic sclerosis
Sasaki, T.; Cao, Y.; Marks, K.; Higashioka, K.; Elahee, M.; Ainsworth, R.; Taylor, K.; Bottini, N.; Wolters, P.; Kamiya, M.; Kim, E. Y.; Boin, F.; Rao, D. A.
10.1101/2025.01.27.635121 — immunology — Posted on 2025-01-29
469 Improved transfection methods of primary cultured astrocytes for observation of cytoskeletal structures
IKOMA, C.; INOUE, K.; KASAI, K.; TSUKUDA, S.; TAMURA, A.; NAKATA, S.; IWATA, Y.; TAMAGAWA, T.; NAKAYAMA, A.; TAKANO, K.; SHIGETOMI, E.; KOIZUMI, S.; NAKAGAWA, H.; TERASAKI, A. G.
10.1101/2025.01.27.635031 — neuroscience — Posted on 2025-01-29
470 Perilysosomal Ca2+ overload impairs autophagic degradation in β-cell lipotoxicity
Nguyen, H. T.; Ly, L. D.; Ngo, T. T. T.; Lee, S. K.; Noriega Polo, C.; Lee, S.; Lee, T.; Cha, S.-K.; Lee, M.-S.; Wiederkehr, A.; Wollheim, C. B.; Park, K.-S.
10.1101/2025.01.27.635047 — physiology — Posted on 2025-01-29
473 Synthetic Mucins as Glycan-Defined Prebiotics
Alty, J. W.; Barnes, C. E.; Nicoli, A.; Turner, B.; Beneman, E. A.; Dugan, A. E.; Brucks, S. D.; Kruger, A. G.; Schrock, R. R.; Ribbeck, K.; Kiessling, L. L.
10.1101/2025.01.27.635133 — biochemistry — Posted on 2025-01-29
474 Insights into global antimicrobial resistance dynamics through the sequencing of enteric bacteria from U.S. international travelers
Sridhar, S.; Worby, C.; Bronson, R. A.; Turbett, S. E.; Oliver, E.; Shea, T.; Rao, S. R.; Sanchez, V.; Becker, M.; Kogut, L.; Slater, D. M.; Harris, J. B.; Walters, M. S.; Walker, A. T.; Knouse, M. C.; Leung, D. T.; Kelly, P.; Ryan, E. T.; LaRocque, R. C.; Earl, A. M.
10.1101/2025.01.27.635056 — genomics — Posted on 2025-01-29
477 Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
Lee, Y.-K.; Xiao, C.; Zhou, X.; Wang, L.; McReynolds, M. G.; Wu, Z.; Purisic, E.; Kim, H.; Li, X.; Pang, Z. P.; Dai, J.; Peng, J.; Yang, N.; Yue, Z.
10.1101/2024.12.30.630813 — neuroscience — Posted on 2025-01-29
481 Cellular and synaptic organization of the Octopus vertical lobe
Bidel, F.; Meirovitch, Y.; Yang, F.; Lichtman, J. W.; Hochner, B.
10.1101/2025.01.29.635406 — neuroscience — Posted on 2025-01-29
483 Xenometabolome of Early-Life Stage Salmonids Exposed to 6PPD-Quinone
Ankley, P. J.; da Silva, F. C.; Hunnie, B.; Roberts, C.; Eriksson, A. N. M.; Kohlman, E.; Corker, J.; Westcott, J.; Germain, B.; Martin, M. J.; Dubiel, J.; Anderson-Bain, K.; Urrutia, R. M.; Hogan, N.; Giesy, J. P.; Wiseman, S.; Krol, E.; Hecker, M.; Brinkmann, M.
10.1101/2024.06.12.598661 — pharmacology and toxicology — Posted on 2025-01-29
489 Neuropathological changes in the nucleus basalis of Meynert in people with type 1 or type 2 diabetes mellitus.
Jiang, W.; Kalsbeek, M. J.; Correa-da-Silva, F.; Kalsbeek, A.; Swaab, D. F.; Siegelaar, S. E.; Yi, C.-X.
10.1101/2025.01.29.635423 — neuroscience — Posted on 2025-01-29
491 Expression profile of the ADHD risk gene ADGRL3 during human neurodevelopment and the effects of genetic variation
McNeill, R. V.; Nieberler, M.; Schickardt, Z.; Radtke, F.; Chiocchetti, A.; Kittel-Schneider, S.
10.1101/2025.01.29.635411 — neuroscience — Posted on 2025-01-29
494 Dataset on Temperature Dependency of Zebrafish Early Development
Miller, A.; Schroeder, K. L.; Braun, K. E.; Steindorf, C.; Ottermanns, R.; Ross-Nickoll, M.; Backhaus, T.
10.1101/2025.01.28.635255 — developmental biology — Posted on 2025-01-29
495 Sensory discrimination of chemical and temperature stimuli in the acoel Symsagittifera roscoffensis
Komarov, N.; Aeschbacher, C.; Sauterel, L.; Zuercher, E.; Bailly, X.; Martinez, P.; Sprecher, S. G.
10.1101/2025.01.28.635210 — animal behavior and cognition — Posted on 2025-01-29
500 Involvement of orexin nerves in early stage of Alzheimer's disease model mice and preventive effect of orexin receptor antagonists
Hada, K.; Murata, Y.; Ohi, Y.; Hashimoto, S.; Watanabe, H.; Ozeki, K.; Saido, T. C.; Saito, T.; Sasaguri, H.; Mizoguchi, H.; Yamada, K.; Wakiya, Y.
10.1101/2025.01.28.635390 — animal behavior and cognition — Posted on 2025-01-29
502 Receptor Allostery Promotes Context-Specific Sonic Hedgehog Signaling During Embryonic Development
Ansari, S. S.; Dillard, M. A.; Ghonim, M.; Zhang, Y.; Stewart, D. P.; Canac, R.; Moskowitz, I. P.; Wright, W. C.; Daly, C. A.; Pruett-Miller, S. M.; Steinberg, J.; Wang, Y.-D.; Chen, T.; Thomas, P.; Bridges, J. P.; Ogden, S. K.
10.1101/2025.01.28.635336 — developmental biology — Posted on 2025-01-29
503 Fine-tuning mechanical constraints uncouple patterning and gene expression in murine pseudo-embryos
Pineau, J.; Ng, J. W.; Mayran, A.; Lopez-Delisle, L.; Osteil, P.; Shoushtarizadeh, A.; Duboule, D.; Gobaa, S.; Gregor, T.
10.1101/2025.01.28.635012 — developmental biology — Posted on 2025-01-29
504 TFE3 fusion proteins drive oxidative metabolism, ferroptosis resistance and general RNA synthesis in translocation renal cell carcinoma
Helleux, A.; Davidson, G.; Lallement, A.; Alhourani, F.; Haller, A.; Michel, I.; Fadloun, A.; Thibault-Carpentier, C.; Su, X.; Lindner, V.; Tricard, T.; Lang, H.; Tannir, N. M.; Davidson, I.; Malouf, G. G.
10.1101/2024.10.24.620047 — cancer biology — Posted on 2025-01-29
507 Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neurons
Krispin, S.; van Zuiden, W.; Danino, Y. M.; Molitor, L.; Rudberg, N.; Bar, C.; Coyne, A.; Meimoun, T.; Waldron, F. M.; Gregory, J. M.; Fisher, T.; Nachshon, A.; Stern-Ginossar, N.; Yacovzada, N. S.; Hornstein, E.
10.1101/2024.01.31.572110 — systems biology — Posted on 2025-01-29
511 Multi-modal refinement of the human heart atlas during the first gestational trimester
De Bono, C.; Xu, Y.; Kausar, S.; Herbane, M.; Humbert, C.; Rafatov, S.; Missirian, C.; Moreno, M.; Shi, W.; Gitton, Y. I.; Lombardini, A.; Vanzetta, I.; Mazaud-Guittot, S.; Chedotal, A.; Baudot, A.; Zaffran, S.; Etchevers, H. C.
10.1101/2024.11.21.624698 — developmental biology — Posted on 2025-01-29
512 Establishment of terminal selector combinations in optic lobe neurons
Simon, F.; Holguera, I.; Chen, Y.-C.; Malin, J.; Valentino, P.; Njoo-Deplante, C.; El-Danaf, R. N.; Kapuralin, K.; Erclik, T.; Konstantinides, N.; Özel, M. N.; Desplan, C.
10.1101/2024.02.05.578975 — developmental biology — Posted on 2025-01-29
513 AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism
Zhang, Z.; Zheng, L.; Chen, Y.; Chen, Y.; Hou, J.; Xiao, C.; Zhu, X.; Zhao, S.; Xiong, J.-W.
10.1101/2024.06.04.597368 — cell biology — Posted on 2025-01-29
514 Generation of transplantable and biologically responsive colonic tissue from human induced pluripotent stem cells using a rapid co-differentiation platform.
Dalleywater, W.; Predeus, A. V.; Cakir, B.; Mazin, P.; Vadakekolathu, J.; Rutella, S.; Meakin, M. L.; Ritchie, A. A.; Montazid, S.; Cuevas Ocana, S.; Holmes, N.; Wright, V.; Seng, F.; Bills, A.; Sculthorpe, D.; Elmentaite, R.; Teichmann, S. A.; Irshad, S.; Tomlinson, I.; Silver, A.; Wildman, R. D.; Hannan, N. R. F.; Rose, F. R.; Ilyas, M.
10.1101/2023.12.08.570795 — cell biology — Posted on 2025-01-29
515 SUN-domain proteins of the malaria parasite Plasmodium falciparum are essential for proper nuclear division and DNA repair
Kandelis-Shalev, S.; Goyal, M.; Elam, T.; Assaraf, S.; Dahan, N.; Farchi, O.; Berenshtein, E.; Dzikowski, R.
10.1101/2024.04.23.590856 — microbiology — Posted on 2025-01-29
516 Emergence of high-connectivity states before epileptic seizures: Multi-patient validation, physiological correlates, and network modeling
Medina Leandro, B. N.; Vila-Vidal, M.; Tost, A.; Khawaja, M.; Carreno, M.; Roldan, P.; Rumia, J.; Centeno, M.; Conde, E.; Donaire, A.; Tauste, A.
10.1101/2025.01.24.634461 — neuroscience — Posted on 2025-01-29
520 Long-read sequencing transcriptome quantification with lr-kallisto
Loving, R. K.; Sullivan, D. K.; Booeshaghi, A. S.; Reese, F.; Rebboah, E.; Sakr, J.; Rezaie, N.; Liang, H. Y.; Filimban, G.; Kawauchi, S.; Oakes, C.; Trout, D.; Williams, B. A.; MacGregor, G.; Wold, B.; Mortazavi, A.; Pachter, L.
10.1101/2024.07.19.604364 — bioinformatics — Posted on 2025-01-29
521 Bridging Earth and Space: A Flexible and Resilient Federated Learning Framework Deployed on the International Space Station
Casaletto, J. A.; Foley, P.; Fernandez, M.; Sanders, L. M.; Scott, R. T.; Ranjan, S.; Jain, S.; Haynes, N.; Boerma, M.; Costes, S. V.; Mackintosh, G.
10.1101/2025.01.14.633017 — bioinformatics — Posted on 2025-01-29
524 Predictive influences on memory encoding: investigating oscillations and the N400 event-related potential component
Jano, S. L.; Schlesewsky, M.; Chatburn, A.; Coussens, S.; Cross, Z. R.; Bornkessel-Schlesewsky, I.
10.1101/2024.09.27.615404 — neuroscience — Posted on 2025-01-29
526 The sodium channel SCN2A regulates cortical excitatory and inhibitory neurogenesis
Uy, J. A.; Dargaei, Z.; Geahchan, S.; Botler, L.; Pan, Y.; Brown, C. O.; Howe, J. L.; Scherer, S. W.; Bains, J. S.; Singh, K. K.
10.1101/2025.01.28.635170 — neuroscience — Posted on 2025-01-28
527 Prey capture learning drives critical period-specific plasticity in mouse binocular visual cortex
Bissen, D.; Cary, B. A.; Zhang, A.; Sailor, K. A.; Van Hooser, S. D.; Turrigiano, G. G.
10.1101/2025.01.28.635373 — neuroscience — Posted on 2025-01-28
531 Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning
Turpin-Moreno, I.; Modrego, A.; Marti-Sarrias, A.; Haeb, A. C.; Garcia-Gonzalez, L.; Ruiz-Roig, N.; Soriano, J.; Penuelas-Haro, I.; Espinet, E.; Tornero, D.; Lao, O.; Acosta, S.
10.1101/2025.01.28.635291 — developmental biology — Posted on 2025-01-28
532 LGBTQ+ realities in the biological sciences
Cooper, K. M.; Busch, C. A.; Accorsi, A.; Applewhite, D. A.; Bhanderi, P. B.; da Rocha-Azevedo, B.; Roy, A. D.; Campanale, J. P.; Chang, F.; Chipuk, J. E.; Ligon, L. A.; Luxton, G. G.; Graham, A. J.; Hochman-Mendez, C.; Ozugergin, I.; Park, Z. M.; Thomas, C. M.; Valm, A. M.; Zhu, H.; Alvania, R. S.
10.1101/2025.01.24.634486 — scientific communication and education — Posted on 2025-01-28
534 Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy
Castillo, J. G.; Fernandez, S.; Campbell, T.; Gonzalez-Ventura, D.; Williams, J.; Ybarra, J.; Hernandez, N. F.; Wells, E.; Portnoy, D. A.; DuPage, M.
10.1101/2024.02.15.580555 — immunology — Posted on 2025-01-28
535 7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in Alzheimer's disease
Radhakrishnan, K.; Zhang, Y.; Mustapha, O.; Weigel, T. K.; Upchurch, C. M.; Tian, X.; Herbert, F.; Huang, W.; Leitinger, N.; Eyo, U. B.; Ai, H.; Ferris, H. A.
10.1101/2025.01.19.633810 — neuroscience — Posted on 2025-01-28
545 Enhanced mRNA delivery using ultrasound-delivered click reactive anchors
Di Ianni, E.; Jeon, J.; Hu, H.; Quintana, J. M.; Lee, C.; Haidar, E. A.; Mohammadi, S.; Zargani-Piccardi, A.; Mahamdeh, M.; Hernandez, I. C.; Ng, T. S. C.; Breyne, K.; Lee, H.; Breakefield, X. O.; Miller, M. A.
10.1101/2025.01.28.635330 — bioengineering — Posted on 2025-01-28
548 Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo
Roh, H.; Kim, D.; Kim, B.; Jeon, Y.; Kim, Y.; Jacko, M.; Xu, F.; Lin, C.; Um, J. W.; Ting, A. Y.
10.1101/2025.01.27.635161 — biochemistry — Posted on 2025-01-28
551 Structural Basis for OAS2 Regulation and its Antiviral Function
Merold, V.; Bekere, I.; Kretschmer, S.; Schnell, A. F.; Kmiec, D.; Sivarajan, R.; Lammens, K.; Liu, R.; Mergner, J.; Teppert, J.; Hirschenberger, M.; Hammes, S.; Buder, K.; Weitz, M.; Koenig, L. M.; Pichlmair, A.; Schwierz, N.; Sparrer, K. M. J.; Lee-Kirsch, M. A.; de Oliveira Mann, C. C.
10.1101/2025.01.28.635220 — biochemistry — Posted on 2025-01-28
552 Enzymes can activate and mobilize the cytoplasmic environment across scales
Dindo, M.; Metson, J.; Ren, W.; Chatzittofi, M.; Yagi, K.; Sugita, Y.; Golestanian, R.; Laurino, P.
10.1101/2025.01.28.635259 — biochemistry — Posted on 2025-01-28
553 Evolutionary potential of the Escherichia coli antimutator ΔnudJ is reduced via altered mutational spectrum
Green, R.; Richards, H.; Ozbilek, D.; Tyrrell, F.; Barton, V.; Lovell, S. C.; Gifford, D. R.; Lagator, M.; McBain, A. J.; Krasovec, R.; Knight, C. G.
10.1101/2025.01.28.635215 — evolutionary biology — Posted on 2025-01-28
554 An oligo walk to identify siRNAs against the circular Tau 12->7 RNA
Welden, J. R.; Margvelani, G.; Miaro, M.; Mathews, D.; Rodgers, D. W.; Stamm, S.
10.1101/2025.01.27.635119 — molecular biology — Posted on 2025-01-28
556 Nipah virus matrix protein utilizes cortical actin to stabilize the virus assembly sites and promote budding
Wang, J.; Kliemke, V.; Liu, J.; Matta, G. L.; Wang, Q.; Luo, Y.; Zhang, M.; Liu, G.; Liu, Q.
10.1101/2025.01.27.635114 — microbiology — Posted on 2025-01-28
561 Advancing (-)-Premarineosin A as a Potent Antimalarial Therapeutic via Metabolic Engineering and Late-Stage Derivatization
McBride, C. M.; McCauley, M.; Harris, N. R.; Amin, S.; Verhey-Henke, L.; Teklemichael, A. A.; Oliphant, E. N.; Dranchak, P.; Curtis, B. J.; Lev, K. L.; Qu, F.; Snodgrass, H. M.; Lewis, J. C.; Inglese, J.; Su, X.-z.; Pereira, F.; Sherman, D. H.
10.1101/2025.01.28.635342 — microbiology — Posted on 2025-01-28
564 Gut microbiota phospholipids regulate intestinal gene expression and can counteract the effects of antibiotic treatment
Zhang, X.-S.; Wang, Y.; Sun, H.; Zerbe, C.; Falcone, E.; Bhattacharya, S.; Zhang, M.; Gao, Z.; Diaz-Rubio, M. E.; Bharj, D.; Patel, D.; Pan, S.; Ro, G.; Grenard, J.; Armstrong, A.; Yin, Y. S.; Dominguez-Bello, M. G.; Holland, S.; Su, X.; Blaser, M. J.
10.1101/2025.01.28.633906 — microbiology — Posted on 2025-01-28
565 Polyethylene terephthalate (PET) primary degradation products affect c-di-GMP-, cAMP-signaling and quorum sensing (QS) in Vibrio gazogenes DSM 21264
Preuss, L.; Alawi, M.; Dumnitch, A.; Trinh, L.; Maison, W.; Burmeister, N.; Poehlein, A.; Daniel, R.; Vollstedt, C.; Streit, W.
10.1101/2025.01.28.635239 — microbiology — Posted on 2025-01-28
568 RNA modifications on Adenosine co-Regulate Macrophage Function
Papavasiliou, F. N.; Griesche, V.; di Giorgio, S.; Tellioglu, I.; Kao, C.-Y.; Stoecklin, G.; Lorenzo, J. P.; Pezzella, L.; Brettschneider, J.
10.1101/2025.01.28.635339 — immunology — Posted on 2025-01-28
570 Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP signaling in dormant disseminated uveal melanoma
Kadamb, R.; Anton, M. L.; Purwin, T. J.; Seeneevassen, L.; Chua, V.; Waltrich, F.; Teh, J.; Nieto, M. A.; Sato, T.; Terai, M.; Roman, S.; de Koning, L.; Zheng, D.; Aplin, A. E.; Aguirre-Ghiso, J.
10.1101/2024.03.05.583565 — cancer biology — Posted on 2025-01-28
571 The Interplay of Furin Cleavage and D614G in Modulating SARS-CoV-2 Spike Protein Dynamics
Shoemaker, S. R.; Luo, M.; Dam, K.-M. A.; Pak, J. E.; Hoffmann, M. A. G.; Marqusee, S.
10.1101/2025.01.27.635166 — biophysics — Posted on 2025-01-28
572 Lipid hydrogen isotope compositions primarily reflect growth water in the model archaeon Sulfolobus acidocaldarius
Harris, C. M.; Kopf, S.; Rhim, J. H.; Cobban, A.; Elling, F. J.; Feng, X.; McFarlin, J.; Weber, Y.; Zhang, Y.; Zhou, A.; Batther, H.; Pearson, A.; Leavitt, W. D.
10.1101/2024.10.24.620110 — microbiology — Posted on 2025-01-28
573 C12ORF57: a novel principal regulator of synaptic AMPA currents and excitatory neuronal homeostasis
Jiang, R.; Chouchane, M.; Moey, C.; Bunt, J.; Li, J.; Allkuraya, F.; Alobeid, E.; Richards, L.; Ullian, E.; Sherr, E.
10.1101/2025.01.08.632037 — neuroscience — Posted on 2025-01-28
574 Neoplastic immune mimicry is a generalizable phenomenon in breast cancer and epithelial CD69 enables early tumor progression
Berens, E. B.; Khou, S.; Huang, E.; Hoffman, A.; Johnson, B.; Kirchberger, N.; Sivagnanam, S.; Calistri, N. L.; Derrick, D.; Liby, T. A.; McLean, I. C.; Alanizi, A. A.; Ozmen, F.; Ozmen, T. Y.; Mills, G. B.; Hwang, E. S.; Schedin, P. J.; Gonzalez, H.; Werb, Z.; Heiser, L. M.; Coussens, L. M.
10.1101/2025.01.17.633673 — cancer biology — Posted on 2025-01-28
576 Building a literature knowledge base towards transparent biomedical AI
Huang, Y.; Han, Z.; Luo, X.; Luo, X.; Gao, Y.; Zhao, M.; Tang, F.; Wang, Y.; Chen, J.; Li, C.; Lu, X.; Qiu, J.; Deng, F.; Jiao, T.; Xue, D.; Shang, H.; Feng, F.; Vu, T. H. H.; Guan, L.; Cartailler, J.-P.; Stitzel, M.; Chen, S.; Brissova, M.; Parker, S.; Liu, J.
10.1101/2024.09.22.614323 — bioinformatics — Posted on 2025-01-28
581 Local alkalinity enhancement using artificial substrates increases survivorship of early-stage coral recruits
Ruszczyk, M.; Rodriguez, S.; Tuen, M.; Rux, K.; Chandragiri, S.; Stickley, M.; Haus, B. K.; Baker, A. C.; Miller, M.; Suraneni, P.; Langdon, C.; Prakash, V. N.
10.1101/2025.01.07.631763 — ecology — Posted on 2025-01-28
582 Leaflet specific phospholipid imaging using genetically encoded proximity sensors
Moore, W. M.; Brea, R. J.; Knittel, C.; Wrightsman, E.; Hui, B.; Loui, J.; Ancajas, C. F.; Best, M. D.; Devaraj, N. K.; Budin, I.
10.1101/2024.05.01.592120 — cell biology — Posted on 2025-01-28
583 Diverse phage defence systems define West African South American pandemic Vibrio cholerae
Adams, D. W.; Jaskolska, M.; Lemopoulos, A.; Stutzmann, S.; Righi, L.; Bader, L.; Blokesch, M.
10.1101/2024.11.23.624991 — microbiology — Posted on 2025-01-28
585 Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS
Bekier, M. E.; Pinarbasi, E.; Mesojedec, J. J.; Ghaffari, L.; de Majo, M.; Ullian, E.; Koontz, M.; Coleman, S.; Li, X.; Tank, E. M.; Waksmacki, J.; Barmada, S.
10.1101/2025.01.27.635090 — neuroscience — Posted on 2025-01-28
588 Identification of a novel papillary renal cell carcinoma molecular subtype characterized by HIF-pathway over-activation
de Nicolas-Hernandez, J.; Arenas, A.; Valdivia, C.; Santos, M.; Lanillos, J.; Bechmann, N.; Peitzsch, M.; Gil-Vilarino, E.; Monteagudo, M.; Mellid, S.; Montero-Conde, C.; Cascon, A.; Leandro-Garcia, L. J.; de Velasco, G.; Duran, I.; Puente, J.; Garcia-Donas, J.; Caleiras, E.; Robledo, M.; Rodriguez-Antona, C.
10.1101/2025.01.24.632989 — cancer biology — Posted on 2025-01-28
589 Caveolin-1 regulates context-dependent signaling and survival in Ewing Sarcoma.
Segal, D.; Wang, X.; Mazloom-Farsibaf, H.; Rajendran, D.; Butler, E.; Chen, B.; Chang, B.-J.; Ahuja, K.; Perny, A.; Bhatt, K.; Reed, D. K.; Castrillon, D.; Lee, J.; Jeffery, E.; Wang, L.; Nguyen, K.; Williams, N. S.; Rajaram, S.; Fiolka, R. P.; Jaqaman, K.; Skapek, S. X.; Hon, G. C.; Amatruda, J.; Danuser, G.
10.1101/2024.09.23.614468 — cancer biology — Posted on 2025-01-28
590 CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks
Abbasova, L.; Urbanaviciute, P.; Hu, D.; Ismail, J. N.; Schilder, B. M.; Nott, A.; Skene, N. G.; Marzi, S. J.
10.1101/2022.03.30.486382 — genomics — Posted on 2025-01-28
593 Planting 10 Million Trees with Lukenya University in Kenya: Methodology and Preliminary Observations and Forecasts
Kyalo, P.; Kungurtserv, V.; Muli, E.; Pietsch, S. A.; Mugo, K.; Kaigongi, M.; Wafula, J.; Muvela, S.; Muasa, M.; Mutua, C.
10.1101/2025.01.09.632148 — ecology — Posted on 2025-01-28
595 Animal septins contain functional transmembrane domains
Perry, J. A.; Werner, M. E.; Omi, S.; Heck, B. W.; Maddox, P. S.; Mavrakis, M.; Maddox, A. S.
10.1101/2023.11.20.567915 — cell biology — Posted on 2025-01-28
596 Noradrenaline causes a spread of association in the hippocampal cognitive map
Koolschijn, R. S.; Parthasarathy, P.; Browning, M.; Przygodda, X.; Clarke, W. T.; Vogels, T. P.; O'Reilly, J. X.; Barron, H. C.
10.1101/2024.08.31.610602 — neuroscience — Posted on 2025-01-28
597 Single neuron contributions to the auditory brainstem EEG
Kuokkanen, P. T.; Kraemer, I.; Koeppl, C.; Carr, C. E.; Kempter, R.
10.1101/2024.05.29.596509 — neuroscience — Posted on 2025-01-28
599 Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism
Dierks, D.; Nir, R.; Shachar, R.; Uzonyi, A.; Garcia-Campos, M. A.; Wiener, D.; Rossmanith, W.; Hanna, J. H.; Slobodin, B.; Antebi, Y.; Scherz-Shouval, R.; Schwartz, S.
10.1101/2024.05.09.593376 — systems biology — Posted on 2025-01-28
604 Delayed dichromatism in waterfowl as a convenient tool for assessing vital rates
Tableau, A.; Henderson, I.; Reeber, S.; Guillemain, M.; Maillard, J.-F.; Caizergues, A.
10.1101/2024.06.04.597326 — ecology — Posted on 2025-01-28
605 Artificial Selection and the Skin Microbiome Independently Predict Parasite Resistance
Kramp, R. D.; Janecka, M.; Tardent, N.; Jokela, J.; Kohl, K. D.; Stephenson, J. F.
10.1101/2024.10.19.619196 — ecology — Posted on 2025-01-28
606 Next-Generation Breast Organoids Capture Tissue Organogenesis with High-Resolution Live Imaging
Rauner, G.; Traugh, N.; Trepicchio, C.; Parrish, M. E.; Mushayandebvu, K.; Kuperwasser, C.
10.1101/2023.10.02.560364 — developmental biology — Posted on 2025-01-28
607 Heterochromatin de novo formation and maintenance in P. falciparum
Perez-Cantero, A.; Llora-Batlle, O.; Pelaez-Conde, I.; Martinez-Guardiola, C.; Cortes, A.
10.1101/2025.01.06.631576 — molecular biology — Posted on 2025-01-28
608 Pathogenetic mechanisms of muscle-specific ribosomes in dilated cardiomyopathy
Murphy, M. R.; Ganapathi, M.; Lee, T. M.; Fisher, J. M.; Patel, M. V.; Jayakar, P.; Buchanan, A.; Rippert, A. L.; Ahrens-Nicklas, R. C.; Nair, D.; Soni, R. K.; Yin, Y.; Yang, F.; Reilly, M. P.; Chung, W. K.; Wu, X.
10.1101/2025.01.02.630345 — molecular biology — Posted on 2025-01-28
609 Self-Supervised Grid Cells Without Path Integration
Pettersen, M.; Schoyen, V. S.; Ostby, M. D.; Malthe-Sorenssen, A.; Lepperod, M. E.
10.1101/2024.05.30.596577 — neuroscience — Posted on 2025-01-28
611 Divalent siRNA for prion disease
Gentile, J. E.; Corridon, T. L.; Serack, F. E.; Echeverria, D.; Kennedy, Z. E.; Gallant-Behm, C. L.; Hassler, M. R.; Kinberger, G.; Kamath, N. G.; Lian, Y.; Gross, K. Y.; Miller, R.; DeSouza-Lenz, K.; Howard, M.; Guzman, K.; Chan, N.; Laversenne, V.; Curtis, D. T.; Fettes, K.; Lemaitre, M.; Cappon, G.; Jackson, A. L.; Yamada, K.; Alterman, J. F.; Coffey, A. A.; Minikel, E. V.; Khvorova, A.; Vallabh, S. M.
10.1101/2024.12.05.627039 — neuroscience — Posted on 2025-01-28
613 Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential
Rossignoli, G.; Oberhuemer, M.; Brun, I. S.; Zorzan, I.; Osnato, A.; Wenzel, A.; van Genderen, E.; Drusin, A.; Panebianco, G.; Magri, N.; Solis, M. A.; Colantuono, C.; van Knippenberg, S. S. F. A.; Pham, T. X. A.; Khodeer, S.; Grumati, P.; Cacchiarelli, D.; Martini, P.; Rivron, N. C.; Pasque, V.; Zylicz, J. J.; Leeb, M.; Martello, G.
10.1101/2025.01.17.633522 — cell biology — Posted on 2025-01-28
614 MIReVTD, a Minimum Information Standard for Reporting Vector Trait Data
Ryan, S. J.; Huxley, P.; Lippi, C.; Pawar, S.; Cator, L.; Rund, S. S. C.; Johnson, L. R.
10.1101/2025.01.27.634769 — ecology — Posted on 2025-01-28
615 From temperate to polar waters: Transition to non-cyanobacterial diazotrophy upon entering the Atlantic gateway of the Arctic Ocean
von Friesen, L. W.; Laber, C. P.; Kristensen, B. H.; Nysted, E.; Sundbom, M.; Bertilsson, S.; Snoeijs-Leijonmalm, P.; Farnelid, H.; Riemann, L.
10.1101/2025.01.27.635040 — ecology — Posted on 2025-01-28
617 Slow oscillation-sleep spindle coupling is associated with fear extinction retention in trauma-exposed individuals
Denis, D.; Bottary, R.; Cunningham, T. J.; Davidson, P.; Yuksel, C.; Milad, M. R.; Pace-Schott, E. F.
10.1101/2025.01.27.634866 — neuroscience — Posted on 2025-01-28
619 Cell-state specific drug-responses are associated with differences in signaling network wiring.
Kramer, N.; van Eijl, R.; Stohn, T.; Tanis, S.; Wessels, L.; Bosdriesz, E.; Mulder, K. W.
10.1101/2025.01.27.635060 — systems biology — Posted on 2025-01-28
620 Symmetry as a Fundamental Principle in Defining Gene Expression and Phenotypic Traits
Zhang, C.; Correia, C.; Weiskittel, T.; Tan, S. H.; Zhang, Z.; Yeo, K.-S.; Zhu, S.; Yong Choong, C.; Li, H.
10.1101/2025.01.27.634930 — systems biology — Posted on 2025-01-28
621 Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry
Boatman, A. K.; Chappel, J. R.; Kirkwood-Donelson, K. I.; Fleming, J. F.; Reif, D. M.; Schymanski, E. L.; Rager, J. R.; Baker, E.
10.1101/2025.01.27.634925 — scientific communication and education — Posted on 2025-01-28
623 A cross-species multimodal database of gene expression in cardiac hypertrophy
Sandmann, C.; Lanzer, J.; Stein, F.; Malovrh, E.; Rudinger, N.; Frey, N.; Saez Rodriguez, J.; Volkers, M.
10.1101/2025.01.27.635074 — physiology — Posted on 2025-01-28
625 Non-Visual Light Sensing Enhances Behavioral Memory and Drives Gene Expression in C. elegans
Ji, Z.; Wang, B.; Liu, J.; Chandra, R. K.; Yang, W.; Long, Y.; Egan, M.; L'Etoile, N.; Ma, D. K.
10.1101/2025.01.27.634647 — physiology — Posted on 2025-01-28
626 Fluorescence Lifetime Imaging Microscopy (FLIM) visualizes internalization and biological impact of nanoplastics in live intestinal organoids
Okkelman, I. A.; Zhou, H.; Borisov, S. M.; Debruyne, A. C.; Lefebvre, A. E. Y. T.; Zoccoler, M. L.; Chen, L.; Devriendt, B.; Dmitriev, R. I.
10.1101/2025.01.27.635069 — pharmacology and toxicology — Posted on 2025-01-28
627 Diet links gut chemistry with cancer risk in C57Bl/6 mice and human colorectal cancer patients
Cohen, Z.; Choi, J.; Peregrina, K.; Khan, S.; Wolfson, S.; Sherman, C.; Augenlicht, L. H.; Kelly, L.
10.1101/2025.01.27.635083 — cancer biology — Posted on 2025-01-28
628 Sequential oxidation of L-lysine by a non-heme iron hydroxylase
Reynolds, E. S.; Smith, T. G.; Rama Damodaran, A.; Bhagi-Damodaran, A.
10.1101/2025.01.27.635104 — biochemistry — Posted on 2025-01-28
630 Progenitor Heterogeneity in the Developing Cortex: Divergent and Complementary Roles of NG2-Progenitors and RGCs
Ojalvo-Sanz, A. C.; Figueres-Onate, M.; Barriola, S.; Pernia-Solanilla, C.; Sanchez-Gonzalez, R.; Delgado Garcia, L.; Lopez-Mascaraque, L.
10.1101/2025.01.27.635022 — developmental biology — Posted on 2025-01-28
631 Delayed Trp53 activation protects Dnmt3a-mutant hematopoietic stem cells from inflammatory attrition.
Marando, L.; Giotopoulos, G.; Madrigal, P.; Azazi, D.; Asby, R.; Calleja-Cervantes, M. E.; Gu, M.; Lara-Astiaso, D.; Wilson, N.; Hannah, R.; Bagri, J.; Calderbank, E.; Laurenti, E.; Bernard, E.; Horton, S.; Gottgens, B.; Papaemmanuil, E.; Agrawal Singh, S.; Gozdecka, M.; Vassiliou, G.; Huntly, B.
10.1101/2025.01.27.635076 — molecular biology — Posted on 2025-01-28
632 Bacteriophage-driven DNA inversions shape bacterial functionality and long-term co-existence in Bacteroides fragilis
Carasso, S.; Keshet-David, R.; Zhang, J.; Hajjo, H.; Kadosh-Kariti, D.; Gefen, T.; Geva-Zatorsky, N.
10.1101/2025.01.27.635102 — microbiology — Posted on 2025-01-28
633 Spatial profiling of central nervous system cellular markers in murine breast cancer to brain metastases
Hogg, K.; Calder, G.; Droop, A.; Yang, M.; Simon, A.; Hunt, M. J.; Kaye, P.; Whittington, M. A.; Chawla, S.; Brackenbury, W. J.
10.1101/2025.01.28.635204 — neuroscience — Posted on 2025-01-28
634 Exploring sex-specific alterations in early Alzheimer's disease using network MRI analyses
Ben Abdallah, I.; Sourty, M.; Rame, M.; Degiorgis, L.; Isik, A.; Mathis, C.; Harsan, L.-A.
10.1101/2025.01.28.635128 — neuroscience — Posted on 2025-01-28
635 Molecular Basis of PAC1R Allosteric Modulation with Lipids in Membranes
Hamilton, N. B.; Yang, B.; Xiang, C.; Li, T.; Schneebeli, S. T.; Li, J.
10.1101/2025.01.27.635027 — biophysics — Posted on 2025-01-28
636 R2TP-like Quaternary Chaperones: a comprehensive overview to understand the dynamic R2SP complex
Santo, P. E.; Chagot, M.-E.; Gizardin-Fredon, H.; Ley, M.; Chenuel, T.; Desligniere, E.; Plassart, L.; Paiva, A. C. F.; Sousa, P. M. F.; Bertrand, E.; Charpentier, B.; Verheggen, C.; Quinternet, M.; Meyer, P.; Bandeiras, T. M.; Cianferani, S.; Plisson-Chastang, C.; MANIVAL, X.
10.1101/2025.01.27.635100 — biophysics — Posted on 2025-01-28
643 A fresh perspective on carp feeding behavior in an aquaculture pond and its consequences for individual growth
Riha, M.; Rabaneda-Bueno, R.; Prchalova, M.; Kajgrova, L.; Vrba, J.; Meador, T. B.; Kuklina, I.; Blaha, M.; Drastik, V.; Kocvara, L.; Vesely, L.
10.1101/2025.01.27.635164 — animal behavior and cognition — Posted on 2025-01-28
644 Mapping eukaryotic chromatin accessibility and histone modifications with DNA deaminase
Dong, W.; Zhang, J.; Dai, L.; Chen, J. P.; Wu, H.; He, R.; Pang, Y.; Wang, Z.; Jian, F.; Ren, J.; Liu, Y.; Tian, Y.; Liu, S.; Zhao, X.; Xie, X. S.
10.1101/2024.12.24.630236 — genomics — Posted on 2025-01-28
646 Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs
Vartiainen, E.; Liyanage, D.; Mazureac, I.; Battaglia, R.; Tegtmeyer, M.; Xu, H. J.; Rasanen, N.; Sealock, J.; McCarroll, S. A.; Nehme, R.; Pietilainen, O.
10.1101/2025.01.28.635252 — molecular biology — Posted on 2025-01-28
652 Thalamic oscillations distinguish natural states of consciousness in humans
Chowdhury, A.; Kaufmann, E.; Schreiner, T.; Koeglsperger, T.; Mehrkens, J.-H.; Remi, J.; Vollmar, C.; Staudigl, T.
10.1101/2025.01.28.635248 — neuroscience — Posted on 2025-01-28
654 Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS
Bekier, M. E.; Pinarbasi, E.; Mesojedec, J. J.; Ghaffari, L.; de Majo, M.; Ullian, E.; Koontz, M.; Coleman, S.; Li, X.; Tank, E. M.; Waksmacki, J.; Barmada, S.
10.1101/2025.01.27.635090 — neuroscience — Posted on 2025-01-28
656 Imbalanced mitochondrial dynamics in human and mouse PD brains
Brown, H. J.; Fan, R. Z.; Bell, R.; Salehe, S. S.; Martinez Martinez, C.; Lai, Y.; Tieu, K.
10.1101/2025.01.27.635175 — neuroscience — Posted on 2025-01-28
657 An anti-amyloidogenic approach to specifically block memory consolidation in mice for therapeutic intervention
Lopez-Garcia, P.; McGreevy, K. R.; Vaquero, M. E.; Ramirez de Mingo, D.; Palle, A.; Popiel, H. A.; Santi, A.; Nagai, Y.; Trejo, J. L.; Carrion-Vazquez, M.
10.1101/2025.01.27.635080 — neuroscience — Posted on 2025-01-28
658 Cigarette smoke and biological age induce degenerative heterogeneity in retinalpigment epithelium
Singh, K.; jin, y.; Hu, M.; Pallazo, I.; Cano,, M.; Hoang, T.; Bhutto, I.; Wang, S.; Sinha, D.; Blackshaw, S.; Qian, J.; Handa, J. T.
10.1101/2025.01.27.635096 — neuroscience — Posted on 2025-01-28
659 Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition
Greenwald, N. F.; Nederlof, I.; Sowers, C.; Ding, D.; Park, S.; Kong, A.; Houlahan, K.; Varra, S.; de Graaf, M.; Geurts, V.; Liu, C.; Ranek, J.; Voorwerk, L.; de Maaker, M.; Kagel, A.; McCaffrey, E.; Khan, A.; Yeh, C.; Camacho, C.; Khair, Z.; Bai, Y.; Piyadasa, H.; Risom, T.; Delmastro, A.; Hartmann, F.; Mangiante, L.; Sotomayor, C.; Schumacher, T.; Ma, Z.; Bosse, M.; van de Vijver, M.; Tibshirani, R.; Horlings, H.; Curtis, C.; Kok, M.; Angelo, M.
10.1101/2025.01.26.634557 — cancer biology — Posted on 2025-01-28
662 MOSHPIT: accessible, reproducible metagenome data science on the QIIME 2 framework
Ziemski, M.; Gehret, L.; Simard, A.; Castro Dau, S.; Risch, V.; Grabocka, D.; Matzoros, C.; Wood, C.; Momo Cabrera, P.; Hernandez-Velazquez, R.; Herman, C.; Evans, K.; Robeson, M. S.; Bolyen, E.; Caporaso, J. G.; Bokulich, N. A.
10.1101/2025.01.27.635007 — bioinformatics — Posted on 2025-01-28
664 Refinement Strategies for Tangram for Reliable Single-Cell to Spatial Mapping
Stahl, M.; Strasser, L. J.; Lio, C. T.; Bernett, J.; Röttger, R.; List, M.
10.1101/2025.01.27.634996 — bioinformatics — Posted on 2025-01-28
668 Target the Heart: a new axis of Alzheimer's disease prevention
Heller, L.; Lowe, A.; Del Rosario Hernandez, T.; Gore, S.; Chatterjee, M.; Creton, R.
10.1101/2025.01.27.634057 — animal behavior and cognition — Posted on 2025-01-28
669 Ancient origin of an urban underground mosquito
Haba, Y.; Aardema, M. L.; Afonso, M. O.; Agramonte, N. M.; Albright, J.; Alho, A. M.; Almeida, A. P. G.; Alout, H.; Alten, B.; Altinli, M.; Amara Korba, R.; Andreadis, S. S.; Anghel, V.; Arich, S.; Arsenault-Benoit, A.; Atyame, C.; Aubry, F.; Avila, F. W.; Ayala, D.; Azrag, R. S.; Babayan, L.; Bear, A.; Becker, N.; Bega, A. G.; Bejarano, S.; Ben-Avi, I.; Benoit, J. B.; Boubidi, S. C.; Bradshaw, W. E.; Bravo-Barriga, D.; Bueno-Mari, R.; Busic, N.; Cabanova, V.; Cabeje, B.; Caputo, B.; Cardo, M. V.; Carpenter, S.; Carreton, E.; Chouaibou, M. S.; Christian, M.; Coetzee, M.; Conner, W. R.; Cornel,
10.1101/2025.01.26.634793 — evolutionary biology — Posted on 2025-01-28
673 Stochastic Modeling of Hematopoietic Stem Cell Dynamics
Quinde, C. A.; Krstanovic, K. E.; Vasquez, P. A.; Kathrein, K. L.
10.1101/2025.01.27.635091 — developmental biology — Posted on 2025-01-28
674 Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis
Sudhahar, V.; Xiao, Z.; Das, A.; Ash, D.; Yadav, S.; Matier, C. D.; Pezacki, A. T.; Chatterjee, B.; Antipova, O. A.; Vogt, S.; McMenamin, M.; Kelley, S.; Gabor, C.; Lee, J.; Jo, H.; Chang, C. J.; Rao, J.; Kaplan, J. H.; Ushio-Fukai, M.; Fukai, T.
10.1101/2025.01.27.634587 — cell biology — Posted on 2025-01-28
676 A dual histone code specifies the binding of heterochromatin protein Rhino to a subset of piRNA source loci
Akkouche, A.; Kneuss, E.; Bornelöv, S.; Renaud, Y.; Eastwood, E. L.; van Lopik, J.; Gueguen, N.; Jiang, M.; Creixell, P.; Maupetit-Mehouas, S.; Sobieszek, A.; Gui, Y.; Nicholson, B. C.; Brasset, E.; Hannon, G. J.
10.1101/2024.01.11.575256 — molecular biology — Posted on 2025-01-28
678 Tick-borne pathogens identified in Hyalomma marginatum (Acari: Ixodidae) collected from various vertebrate hosts in the South of France
Bernard, C.; Pollet, T.; Galon, C.; Joly Kukla, C.; Cicculli, V.; Falchi, A.; Grech-Angelini, S.; Poli, P.-E.; Bastien, M.; Combes, B.; Moutailler, S.; Holzmuller, P.; Vial, L.
10.1101/2024.03.01.582933 — microbiology — Posted on 2025-01-28
679 Rapid catecholamine trafficking regulates neutrophil functions and neutrophil-platelet interactions
Mohr, J. M.; Schmitz, A.; Dinarvand, M.; Sangeetha, S.; Hill, B. F.; Wulfert, F.; Neubert, E.; Shumanska, M.; Kaushik, S.; Kartaschew, L.; Bogeski, I.; Daniel, J.; Jung, S.; Eble, J.; Erpenbeck, L.; Kruss, S.
10.1101/2025.01.27.634021 — immunology — Posted on 2025-01-28
680 Musicians' brains at rest: Multilayer network analysis of MEG data
Mandke, K.; Tewarie, P.; Adjamian, P.; Schuermann, M.; Meier, J.
10.1101/2024.01.02.573886 — neuroscience — Posted on 2025-01-28
682 Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Mice Consuming Alcohol Attenuates Glycolysis
Ehinger, Y.; Laguesse, S.; Phamluong, K.; Salvi, A.; Hoisington, Z. W.; Soneja, D.; Gunasekaran, S.; Sei, Y. J.; Nakamura, K.; Ron, D.
10.1101/2023.11.29.569312 — neuroscience — Posted on 2025-01-28
686 Rhythmic sampling of multiple decision alternatives in the human brain
Siems, M.; Cao, Y.; Tohidi-Moghaddam, M.; Donner, T. H.; Tsetsos, K.
10.1101/2023.12.08.570734 — neuroscience — Posted on 2025-01-28
689 Phylogenetic diversity of light dependent phosphorylation of Thr78 in Rca
Bhatnagar, N.; Chung, S. S.; Hodge, J.; Boyd, R.; Kim, S. Y.; Sands, M.; Leakey, A.; Ort, D. R.; Burgess, S. J.
10.1101/2024.08.27.609719 — plant biology — Posted on 2025-01-28
690 SCAN-ACT: Adoptive T Cell Therapy Target Discovery Through Single-Cell Transcriptomics
Testa, S.; Pal, A.; Subramanian, A.; Varma, S.; Tang, J. P.; Graham, D.; Arfan, S.; Pan, M.; Bui, N. Q.; Ganjoo, K. N.; Dry, S.; Huang, P. H.; van de Rijn, M.; Jiang, W.; Kalbasi, A.; Moding, E. J.
10.1101/2025.01.18.633736 — cancer biology — Posted on 2025-01-28
692 Pathway activation model for personalized prediction of drug synergy
Trac, Q. T.; Huang, Y.; Erkers, T.; Östling, P.; Bohlin, A.; Osterroos, A.; Vesterlund, M.; Jafari, R.; Siavelis, I.; Backvall, H.; Kiviluoto, S.; Orre, L.; Rantalainen, M.; Lehtiö, J.; Lehmann, S.; Kallioniemi, O.; Pawitan, Y.; Vu, T. N.
10.1101/2024.06.05.597583 — bioinformatics — Posted on 2025-01-28
695 Large-scale composite hypothesis testing for omics analyses.
De Walsche, A.; Gauthier, F.; Boissot, N.; Charcosset, A.; Mary-Huard, T.
10.1101/2024.03.17.585412 — genomics — Posted on 2025-01-28
696 Decoding human placental cellular and molecular responses to maternal obesity and fetal growth
Jiang, H.; Derisoud, E.; Parreira, D.; Taebnia, N.; Jannig, P. R.; Shafagh, R. Z.; Zhao, A.; Li, C.; Ortiz, M.; Maliqueo, M. A.; Stener-Victorin, E.; Lauschke, V. M.; Deng, Q.
10.1101/2025.01.27.634981 — developmental biology — Posted on 2025-01-28
698 A comprehensive molecular atlas of the cell types in the mouse liver
Pietila, R.; Genove, G.; Mocci, G.; Miao, Y.; Liu, J.; Leptidis, S.; Del Gaudio, F.; Uhrbom, M.; Vazquez-Liebanas, E.; Gustafsson, S.; Buyandelger, B.; Raschperger, E.; Björkegren, J. L. M.; Hansson, E. M.; Gaengel, K.; Mäe, M. A.; Jeansson, M.; Vanlandewijck, M.; He, L.; Strell, C.; Peng, X.-R.; Lendahl, U.; Betsholtz, C.; Muhl, L.
10.1101/2025.01.24.634721 — cell biology — Posted on 2025-01-28
700 Evaluating Seqstant LiveGene Analysis in Real-Time Assessment of Metagenomic Next-Generation Sequencing (mNGS) Data from Respiratory Samples
Boutin, S.; Klein, S.; Untergasser, G.; Loka, T. P.; Jakob, S.; Khatamzas, E.; Wrettos, G.; Knobloch, H.; Nurjadi, D.
10.1101/2025.01.24.634829 — microbiology — Posted on 2025-01-28
701 Optimized antibody with W32I mutation enhances antiviral efficacy against influenza
Guan, S.; Wang, Q.; Nie, J.; Yao, X.; Xie, K.; Zhao, W.; Chang, Y.; Zhu, L.; Hui, J.; Yin, T.; Liu, X.; Shan, Y.
10.1101/2025.01.24.634663 — immunology — Posted on 2025-01-28
703 Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during microglial activation
Arnould, B.; Martz, A.; Belzanne, P.; Peralta, F. A.; Cevoli, F.; Hovhannisyan, V.; Goumon, Y.; Hosy, E.; Specht, A.; Grutter, T.
10.1101/2025.01.24.634652 — neuroscience — Posted on 2025-01-28
705 Mouse Cortical Cellular Diversification Through Lineage Progression of Radial Glia
LI, X.; Yang, L.; Gao, Y.; Wang, Z.; Li, Z.; Liu, G.; Xu, Z.; Zhang, Z.; You, Y.; Yang, Z.
10.1101/2025.01.24.634707 — neuroscience — Posted on 2025-01-28
708 OxLDL-targeted Chimeric Antigen Receptor T Regulatory Cells Reduce Atherosclerotic Plaque Development
Schwab, R. D.; Hong, S. J.; Bi, X.; Degaramo, D. A.; Faruqi, A.; Brookens, S. K.; Keane, J. T.; Liu, F.; Musunuru, K.; Rader, D. J.; Posey, A. D.
10.1101/2025.01.24.634830 — synthetic biology — Posted on 2025-01-28
710 Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease.
Olivas, A. O. D.; Ngai, P. C. M.; Schahrer, E.; Olortegui, K. S.; Cursio, J. F.; Akiyama, S.; Chang, E. B.; Shen, L.; Umanskiy, K.; Rubin, D. T.; Zemmour, D.; Weber, C. R.
10.1101/2025.01.27.635092 — pathology — Posted on 2025-01-28
711 Spatial gene expression of human coronary arteries revealed the molecular features of diffuse intimal thickening in explanted hearts
Li, B.; Leung, S.; Elishaev, M.; Cheng, W.-H.; Mocci, G.; Björkegren, J. L.; Lai, C.; Singh, A.; Wang, Y.
10.1101/2025.01.20.633995 — pathology — Posted on 2025-01-28
712 Deletion of PIEZO1 in adult cardiomyocytes accelerates cardiac aging and causes premature death
Martinac, B.; Feneley, M. P.; Macdonald, P. S.; Yu, Z.-Y.; Kesteven, S. H.; Cheng, D.; Guo, Y.; Xaymardan, M.; Lei, H.; Nadar, E.; Wu, J.; Cox, C. D.
10.1101/2025.01.20.633994 — biophysics — Posted on 2025-01-28
713 Restoring Cholesterol Efflux in Vascular Smooth Muscle Cells Transitioning into Foam Cells Through Liver X Receptor Activation
Borras, C.; Rotllan, N.; Grinan, R.; Santos, D.; Mourin, M.; Soto-Carricas, B.; Camacho, M.; Tondo, M.; Canyelles, M.; Blanco-Vaca, F.; Escola-Gil, J.-C.
10.1101/2025.01.22.634420 — biochemistry — Posted on 2025-01-28
714 Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the anterior brainstem
Kilpinen, S.; Virtanen, L.; Bodington Celma, S.; Bonsdorff, A.; Heliölä, H.; Achim, K.; Partanen, J.
10.1101/2025.01.26.634960 — developmental biology — Posted on 2025-01-28
715 A niche-dependent redox rheostat regulates epithelial stem cell fate in the distal colon
Chen, X.; Raghunathan, K.; Bao, B.; Ngwa, E.; Kwong, A.; Wu, Z.; Babcock, S.; Baek, C.; Ye, G.; Muppirala, A.; Peng, Q.; Rutlin, M.; Bhaumik, M.; Yang, D.; Kotlarz, D.; Jadhav, U.; Rao, M.; Weerapana, E.; Zhou, X.; Ordovas-Montanes, J.; Snapper, S. B.; Thiagarajah, J. R.
10.1101/2025.01.26.634856 — cell biology — Posted on 2025-01-28
716 Genetic dissection of cyclic di-GMP signaling in Pseudomonas aeruginosa via diguanylate cyclase disruption
Martino, R. A.; Volke, D. C.; Tenaglia, A. H.; Tribelli, P. M.; Nikel, P. I.; Smania, A. M.
10.1101/2025.01.26.634905 — microbiology — Posted on 2025-01-28
718 A Grapevine MYC2-MYB24 Regulatory Module Activates Terpenoid Biosynthesis Upon Methyl Jasmonate Elicitation
Zhang, C.; Echeverria, J.; Foresti, C.; Santiago, A.; El Idrissi Moubtassim, H.; Amato, A.; Sonego, P.; Pindo, M.; Zenoni, S.; Moretto, M.; Matus, J. T.
10.1101/2025.01.27.635049 — plant biology — Posted on 2025-01-28
720 Applied Machine Learning for human bacteriaMALDI-TOF Mass Spectrometry: a systematicreview
Schmidt-Santiago, L.; Guerrero-Lopez, A.; Sevilla-Salcedo, C.; Rodriguez-Temporal, D.; Rodriguez-Sanchez, B.; Gomez-Verdejo, V.
10.1101/2025.01.25.634879 — bioengineering — Posted on 2025-01-28
722 Effects of host sex, age and behaviour on co-infection patterns in a wild ungulate
Berland, F.; Bourret, V.; Peroz, C.; Malandrin, L.; Bonsergent, C.; Bailly, X.; Masseglia, S.; Nouvel, X.; Lagree, A.-C.; Rouxel, C.; Dimeglio, C.; Izopet, J.; Ollivier, V.; Boulinier, T.; Villena, I.; Aubert, D.; Sluydts, V.; Le Loc'h, G.; Bonnet, A.; Chaval, Y.; Merlet, J.; Lourtet, B.; Gilot-Fromont, E.; Verheyden, H.
10.1101/2025.01.27.635057 — ecology — Posted on 2025-01-28
725 Arousal State Control of Physiological Human Brain Pulsations
Järvelä, M.; Kananen, J.; Helakari, H.; Korhonen, V.; Huotari, N.; Raitamaa, L.; Tuunanen, J.; Kallio, M.; Piispala, J.; Ansakorpi, H.; Kiviniemi, V.
10.1101/2025.01.27.635032 — neuroscience — Posted on 2025-01-28
729 Antioxidant supplementation blunts the proteome response to three weeks of sprint interval training preferentially in human type 2 muscle fibres
Wyckelsma, V. L.; Murgia, M.; Kamandulis, S.; Gastadello, S.; Brazaitis, M.; Snieckus, A.; Eimantas, N.; Paasuke, M.; Edman, S.; Apro, W.; Andersson, D. C.; Westerblad, H.; Venckunas, T.
10.1101/2025.01.27.634979 — physiology — Posted on 2025-01-27
731 Contrasting genetic differentiation of urban and rural populations of two grassland lepidopterans across Europe
Kivela, S. M.; Lee, K. M.; Adamidis, G.; Bonelli, S.; Hendrickx, F.; Huemer, P.; Kadlec, T.; Kankaanpaa, T.; Minard, G.; Nielsen, M.; Piano, E.; Tammaru, T.; Zografou, K.; Merckx, T.
10.1101/2025.01.27.635009 — evolutionary biology — Posted on 2025-01-27
732 A short cut to sample coverage standardization in meta-barcoding data provides new insights into land use effects on insect diversity
Kortmann, M.; Chao, A.; Chiu, C.-H.; Heibl, C.; Mitesser, O.; Moriniere, J.; Bozicevic, V.; Hothorn, T.; Rothacher, J.; Englmeier, J.; Ewald, J.; Fricke, U.; Ganuza, C.; Haensel, M.; Moning, C.; Redlich, S.; Rojas-Botero, S.; Tobisch, C.; Uhler, J.; Zhang, J.; Steffan-Dewenter, I.; Mueller, J.
10.1101/2025.01.27.635018 — ecology — Posted on 2025-01-27
735 Decoding the immune response in leptomeningeal disease through single-cell sequencing of cerebrospinal fluid
Nieto, P.; Klinsing, S.; Caratu, G.; Dettki, M.; Marchese, D.; Weber, K. J.; Morabito, S.; Lorden, P.; Ruano, I.; Imkeller, K.; Velasco, M. A.; Vidal, S.; Melero, J. L.; Euskirchen, P.; Czabanka, M.; Plate, K. H.; Harter, P. N.; Pascual-Reguant, A.; Steinbach, J. P.; Heyn, H.; Zeiner, P. S.; Nieto, J. C.
10.1101/2025.01.27.634744 — immunology — Posted on 2025-01-27
737 Systematic Evaluation of Normalization Approaches in Tandem Mass Tag and Label-Free Protein Quantification Data Using PRONE
Arend, L.; Adamowicz, K.; Schmidt, J. R.; Burankova, Y.; Zolotareva, O.; Tsoy, O.; Pauling, J. K.; Kalkhof, S.; Baumbach, J.; List, M.; Laske, T.
10.1101/2025.01.27.634993 — bioinformatics — Posted on 2025-01-27
740 Immunity can impose a reproduction-survival tradeoff on human malaria parasites
Patterson, D. D.; Childs, L. M.; Stopard, I. J.; Chitnis, N.; Serrato-Arroyo, S.; Greischar, M. A.
10.1101/2025.01.27.635035 — evolutionary biology — Posted on 2025-01-27
743 Generalizable prediction of liquid-liquid phase separation from protein sequence
MohammadHosseini, A. M.; Teimouri, H.; Gureghian, V.; Najjar, R.; Lindner, A. B.; Pandi, A.
10.1101/2025.01.27.635039 — molecular biology — Posted on 2025-01-27
746 Addressing SARS-CoV-2 Evolution: Neutralization of Emerging Variants of Concern by the AVX/COVID-12 'Patria' Vaccine Based on HexaPro-S Ancestral Wuhan Spike or Its Updated BA.2.75.2 Version
Carballo-Uicab, G.; Mellado-Sanchez, G.; Gonzalez-Gonzalez, E.; Salinas-Trujano, J.; Mendoza-Salazar, I.; Lopez-Olvera, K.; Gomez-Castellano, K. M.; Salazar, M. I.; Torres-Flores, J. M.; Chagoya-Cortes, H. E.; Paz-De la Rosa, G.; Mena, I.; Rojas-Martinez, O.; Lara-Puente, J. H.; Peralta-Sanchez, G. J.; Sarfati-Mizrahi, D.; Torres-Flores, A.; Sun, W.; Krammer, F.; Garcia-Sastre, A.; Palese, P.; Lopez-Macias, C.; Lozano-Dubernard, B.; Perez-Tapia, S. M.; Almagro, J. C.
10.1101/2025.01.23.634579 — immunology — Posted on 2025-01-27
747 Cross-species comparative modelling of antimicrobial host responses ex vivo in human and murine precision cut lung slices and in vivo in mice
Choltus, H.; Prados, J.; Bianchi, N.; Heikkila, N.; Serre-Beinier, V.; Karenovics, W.; Badat, B.; Eberhardt, C.; Becattini, S.; Schmolke, M.
10.1101/2025.01.27.634989 — immunology — Posted on 2025-01-27
755 High-throughput Mucus Microrheology for Phenotyping and Disease Modeling
Ling, F.; Sahin, A. T.; Miller Naranjo, B.; Aime, S.; Roth, D.; Tepho, N.; Vendrame, A.; Emken, E.; Kiechle, M.; Tesfaigzi, Y.; Lieleg, O.; Nawroth, J. C.
10.1101/2025.01.09.632077 — bioengineering — Posted on 2025-01-27
756 Molecular Mechanisms of Drug Resistance and Compensation in SARS-CoV-2 Main Protease: The Interplay Between E166 and L50
Zvornicanin, S. N.; Shaqra, A. M.; Flynn, J.; Carias Martinez, H.; Jia, W.; Moquin, S.; Dovala, D.; Bolon, D. N.; Kurt Yilmaz, N.; Schiffer, C. A.
10.1101/2025.01.24.634813 — biochemistry — Posted on 2025-01-27
758 Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons
Barrett, A.; Varol, E.; Weinreb, A.; Taylor, S. R.; McWhirter, R. M.; Cros, C. C.; Vidal, B.; Basaravaju, M.; Poff, A.; Tipps, J. A.; Majeed, M.; Wang, C.; Bayer, E. A.; Reilly, M. B.; Yemini, E.; Sun, H.; Hobert, O.; Miller, D. M.; Hammarlund, M.
10.1101/2025.01.26.634951 — genomics — Posted on 2025-01-27
760 Star Power: Early life stages of an endangered sea star are robust to current and near-future warming
Hodin, J.; Anteau, F. P.; Ashcraft, B. F.; Brito, M.; Curliss, F.; Kalytiak-Davis, A. R.; Peng, J. S.; Schwab, C. J.; Valdez, V. V.; Weertman, W.
10.1101/2025.01.25.634808 — ecology — Posted on 2025-01-27
761 Optimizing multifunctional fluorescent ligands for intracellular labeling
Kumar, P.; Vevea, J. D.; Tkachuk, A. N.; Campbell, K.; Watson, E. T.; Ayala, A. X.; Grimm, J. B.; Chapman, E. R.; Solecki, D. J.; Lavis, L. D.
10.1101/2022.07.02.498544 — cell biology — Posted on 2025-01-27
763 Persistent antigen is essential for sustaining Leishmania-specific memory CD4+ T cells and long-term immunity
Mou, Z.; Zayats, R.; Salako, E.; Ikeogu, N.; Onwah, S. S.; Liu, D.; Hamana, H.; Tan, D.; Kishi, H. K.; Leung, C.; Arsenio, J.; Murooka, T.; Uzonna, J. E.
10.1101/2025.01.26.633721 — immunology — Posted on 2025-01-27
764 Type I and type III interferon receptor knockout chickens: Novel models for unraveling interferon dynamics in influenza infection
Alhussien, M.; Vikkula, H. K.; Klinger, R.; Zenner, C.; Frueh, S. P.; Negi, R.; von Heyl, T.; Schleibinger, S.; Brunner, M.; Berghof, T. V.; Schade, B.; Aboukhadra, B.; Rautenschlein, S.; Preisinger, R.; Sid, H.; Schusser, B.
10.1101/2025.01.24.634794 — immunology — Posted on 2025-01-27
765 Spatiotemporal Complexity in the Psychotic Brain
Li, Q.; Liu, J.; Pearlson, G. D.; Chen, J.; Wang, Y.-P.; Turner, J. A.; Calhoun, V. D.
10.1101/2025.01.14.632764 — neuroscience — Posted on 2025-01-27
766 Sleep increases propagation speed of physiological brain pulsations
Elabasy, A.; Helakari, H.; Vayrynen, T.; Rajna, Z.; Huotari, N.; Raitamaa, L.; Isokoski, V.; Jarvela, M.; Kaakinen, M.; Piispala, J.; Kallio, M.; Korhonen, V.; Seppanen, T.; Kiviniemi, V.
10.1101/2025.01.09.632145 — neuroscience — Posted on 2025-01-27
771 Decoy-seq unlocks scalable genetic screening for regulatory small noncoding RNAs
Choi, B.; Sobti, S.; Soto, L. M.; Charbonneau, T.; Sababi, A.; Navickas, A.; Najafabadi, H. S.; Goodarzi, H.
10.1101/2025.01.25.634869 — systems biology — Posted on 2025-01-27
776 Atypical epigenetic and small RNA control of degenerated transposons and their fragments in clonally reproducing Spirodela polyrhiza
Dombey, R.; Buendia-Avila, D.; Barragan-Borrero, V.; Diezma-Navas, L.; Ponce-Mane, A.; Vargas-Guerrero, J. M.; Elias, R.; Mari-Ordonez, A.
10.1101/2024.04.03.587901 — plant biology — Posted on 2025-01-27
777 Spillover is the dominant non-photochemical quenching mechanism in angiosperms
Nanda, S.; Cainzos, M.; Shutova, T.; Fataftah, N.; Fleig, V.; Lihavainen-Bag, J.; Bag, P.; Holzwarth, A. R.; Jansson, S.
10.1101/2025.01.26.634902 — plant biology — Posted on 2025-01-27
778 Optimized protocols for commonly-used murine models of heart failure with preserved ejection fraction.
McIntosh, B.; Elbassioni, A.; Raheem, A.; MacDonald, E. A.; Nicklin, S. A.; Koay, Y. C.; Cameron, E. R.; Loughrey, C. M.; O'Sullivan, J. F.
10.1101/2025.01.22.634221 — physiology — Posted on 2025-01-27
780 Lipidomic Analysis Reveals Drug-Induced Lipoxins in Glaucoma Treatment
D, M. M.; Maurya, S.; Ho, J.; Livne-Bar, I.; Chan, D.; Buys, Y.; Sit, M.; Trope, G.; FLANAGAN, J.; gronert, k.; Sivak, J. M.
10.1101/2025.01.24.634771 — pharmacology and toxicology — Posted on 2025-01-27
781 Cellular and mitochondrial effects of a gold-N Heterocyclic Carbene on LNCaP and PC3 prostate cancer cell lines
Eguida Sangouard, J.; Cheron, M.; Rivrais, G.; Alziari, S.; Cisnetti, F.; Gautier, A.; Garreau-Balandier, I.; Vernet, P.
10.1101/2025.01.25.634883 — pharmacology and toxicology — Posted on 2025-01-27
782 Rhamnose-mediated modulation of hair follicle growth: insights from chemical genomics
Li, X.; Liu, Y.; Li, L.; Jiang, W.; Ma, S.; Cao, R.; Zhang, Y.; Xiao, R.; Wang, D.; Yang, Z.
10.1101/2025.01.26.634903 — pharmacology and toxicology — Posted on 2025-01-27
783 DUSP11 is an intracellular innate immune checkpoint in lung adenocarcinoma
Thomas, B. J.; Bai, X.; Cryer, B. J.; Escobar, S. M.; Allen, L.-A. H.; Daniels, M. A.; Lange, M. J.; Burke-Aguero, D. H.
10.1101/2025.01.24.634797 — cancer biology — Posted on 2025-01-27
786 Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs and CD8+ T cells
Dong, F.; Zhang, S.; Song, K.; Jiang, L.; Hu, L.-P.; Li, Q.; Zhang, X.-L.; li, j.; Feng, M.; Cai, Z.-W.; Yao, H.-F.; Li, R.-k.; Li, H.; Chen, J.; Hu, X.; Wang, J.; Jiang, C.; Zhu, H. H.; Wang, C.; Da, L.; Zhang, Z.; Bao, Z.; Wang, X.; Jiang, S.-H.
10.1101/2024.10.15.618536 — cancer biology — Posted on 2025-01-27
787 Avoidance of pyroptosis accounts for the relatively high metastatic potential observed in early hybrid EMT states
Verma, A.; Genna, A.; Vinik, Y.; Nataraj, N. B.; Abedrabbo, M.; Selvadurai, B. R.; Bhandari, T.; Aharoni, N.; Ramesh, P.; Boguslavski, B.; Drago, D.; Salame, T. M.; Prior, A.; Levin, Y.; Weizman, E.; Zhu, R.; Caldas, C.; Rueda, O. M.; Lev, S.; Yarden, Y.
10.1101/2025.01.26.634904 — cancer biology — Posted on 2025-01-27
799 Clinical performance evaluation of a tiling amplicon panel for whole genome sequencing of respiratory syncytial virus
Nunley, B. E.; Weixler, A.; Kim, H. G.; Xie, H.; Sereewit, J.; Hajian, P.; Ellis, S. E.; Mills, M. G.; Perez-Osorio, A. C.; Goya, S.; Gov, J.; Dewar, R.; Fernandes, G.; Templeton, K. E.; Maloney, D. M.; Greninger, A. L.; Roychoudhury, P.
10.1101/2025.01.26.634892 — genomics — Posted on 2025-01-27
803 Moving towards more holistic machine learning-based approaches for classification problems in animal studies
Christensen, C.; Ferreira, A.; Cherono, W.; Maximiadi, M.; Nyaguthii, B.; Ogino, M.; Herrera, D.; Farine, D.
10.1101/2024.10.18.618969 — ecology — Posted on 2025-01-27
805 Behavior Outpaces Form when Linking Traits to Ecological Responses within Populations: A Meta-Analysis
Rota, T.; Raffard, A.; Lang, I.; Petitjean, Q.; Jacquin, L.; Dezerald, O.; Blanchet, S.; Hendry, A. P.; Cereghino, R.
10.1101/2025.01.26.634944 — ecology — Posted on 2025-01-27
807 Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16
Ru, Y.; Ma, M.; Zhou, X.; Kriti, D.; Cohen, N.; Souza, S.; Schaniel, C.; Motch Perrine, S. M.; Kuo, S.; Pichurin, O.; Pinto, D.; Housman, G.; Holmes, G.; Schadt, E.; van Bakel, H.; Zhang, B.; Jabs, E. W.; Wu, M.
10.1101/2024.02.11.579844 — developmental biology — Posted on 2025-01-27
808 Complete genome sequence assembly elucidates evolution and regulation of 5S rDNA loci in the greater duckweed Spirodela polyrhiza
Stepanenko, A.; Schubert, V.; Chen, G.; Kishchenko, O.; Michael, T. P.; Lam, E.; Hrmova, M.; Schubert, I.; Borisjuk, N.
10.1101/2025.01.26.634961 — molecular biology — Posted on 2025-01-27
810 Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route
Johnston, S. C.; Qiu, J.; Norris, S. L.; Panchal, R.; Punger, E. M.; Teague, M.; Moore, J. L.; Dyer, D. N.; Frick, O. M.; Stevens, S. C.; Fiallos, J.; Mills, H. L.; Blue, E. L.; Sifford, W. B.; McCarson, T.; Casselman, A.; Latty, J. D.; Huie, K. E.; Adolphi, R.; Nalca, A.
10.1101/2025.01.26.634958 — microbiology — Posted on 2025-01-27
811 Particular Amino Acid on Lateral Interface Maintains FtsZ Function Under Acid Stress in Streptococcus mutans
Chen, Y.; Li, Y.; Niu, J.; Yang, L.; Chi, Y.; Cai, X.; Xin, F.; Zhang, J.; Fang, X.; Mondal, M.; Gao, Y.; Wang, X.
10.1101/2025.01.26.634952 — microbiology — Posted on 2025-01-27
812 Resident Tissue Macrophages Govern Intraocular Pressure Homeostasis
Liu, K. C.; Grimsrud, A. O.; Suarez, M. F.; Schuman, D.; De Ieso, M. L.; Kuhn, M.; Kelly, R. A.; Mathew, R.; Kalnitsky, J.; Mack, M.; Ginhoux, F.; Bupp-Chickering, V.; Balasubramanian, R.; John, S. W. M.; Stamer, W. D.; Saban, D. R.
10.1101/2025.01.25.634888 — immunology — Posted on 2025-01-27
813 Single-Cell Genomics Elucidates Molecular Variations and Regulatory Mechanisms in Circulating Immune Cells
Yin, J.; Zheng, Y.; Huang, Z.; Zhou, W.; Yuan, Y.; Cai, P.; Bai, Y.; Yang, S.; Gao, Y.; Duan, S.; Wang, Y.; Zhang, W.; Zhang, X.; Wei, Y.; Xu, Z.; Huang, Y.; Liu, Y.; Wang, W.; Yang, T.; Lv, J.; Zhang, Z.; Chen, X.; Zhang, X.; Li, F.; Zhang, Y.; Zeng, G.; Wang, X.; Ma, W.; Hou, G.; Hao, S.; Liu, C.; Lai, Y.; Wang, B.; Li, Y.; Zhang, W.; Gao, P.; Xie, J.; Esteban, M. A.; Gu, Y.; Ji, J.; Qi, T.; Liu, B.; Wang, J.; Yang, J.; Xu, X.; Liu, L.; Jin, X.; Liu, C.
10.1101/2025.01.26.634963 — immunology — Posted on 2025-01-27
814 Balancing Integration and Segregation: StructuralConnectivity as a Driver of Brain Network Dynamics
Palma-Espinosa, J.; Orellana-Villouta, S.; Coronel-Oliveros, C.; Maidana, J. P.; Orio, P.
10.1101/2025.01.24.634823 — neuroscience — Posted on 2025-01-27
818 EPISeg: Automated segmentation of the spinal cord on echo planar images using open-access multi-center data
Banerjee, R.; Kaptan, M.; Tinnermann, A.; Khatibi, A.; Dabbagh, A.; Büchel, C.; Kündig, C. W.; Law, C. S. W.; Pfyffer, D.; Lythgoe, D. J.; Tsivaka, D.; Van De Ville, D.; Eippert, F.; Muhammad, F.; Glover, G. H.; David, G.; Haynes, G.; Haaker, J.; Brooks, J. C. W.; Finsterbusch, J.; Martucci, K. T.; Hemmerling, K. J.; Mobarak-Abadi, M.; Hoggarth, M. A.; Howard, M. A.; Bright, M. G.; Kinany, N.; Kowalczyk, O. S.; Freund, P.; Barry, R. L.; Mackey, S.; Vahdat, S.; Schading, S.; McMahon, S. B.; Parish, T.; Marchand-Pauvert, V.; Chen, Y.; Smith, Z. A.; Weber, K. A.; De Leener, B.; Cohen-Adad, J.
10.1101/2025.01.07.631402 — neuroscience — Posted on 2025-01-27
819 A unified rodent atlas reveals the cellular complexity and evolutionary divergence of the dorsal vagal complex
Hes, C.; Tomlinson, A. J.; Michielsen, L.; Murdoch, H. J.; Soltani, F.; Kokoeva, M.; Sabatini, P. V.
10.1101/2024.09.19.613879 — neuroscience — Posted on 2025-01-27
820 Running to remember: The effects of exercise on perineuronal nets, microglia, and hippocampal angiogenesis in female and male mice
Maheu, M. G.; James, N.; Clark, Z.; Yang, A.; Patel, R.; Beaudette, S. M.; MacPherson, R. E. K.; Duarte-Guterman, P.
10.1101/2023.11.24.568577 — neuroscience — Posted on 2025-01-27
823 TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress
Anand, J. R.; Droby, G. N.; Joseph, S.; Patel, U.; Zhang, X.; Klomp, J. A.; Der, C. J.; Purvis, J. E.; Wolff, S. C.; Bowser, J.; Vaziri, C.
10.1101/2025.01.26.634889 — cancer biology — Posted on 2025-01-27
824 Clinico-genomic features predict distinct metastatic phenotypes in cutaneous melanoma
Aprati, T. J.; Day, C.-P.; Lee, D.; Pan, A.; Jee, J.; Tarantino, G.; Manos, M. P.; Faulkner, H.; Holovatska, M. M.; Khaddour, K.; Feng, C. H.; Burke, K. P.; Glettig, M.; Weaver Ohler, Z.; El Meskini, R.; Hodi, F. S.; Haq, R.; Shoushtari, A. N.; Schultz, N.; Ishizuka, J.; Gusev, A.; Griffith, M.; Kehl, K. L.; Liu, D.
10.1101/2025.01.24.633441 — cancer biology — Posted on 2025-01-27
825 Identification of a novel papillary renal cell carcinoma molecular subtype characterized by HIF-pathway over-activation
de Nicolas-Hernandez, J.; Arenas, A.; Valdivia, C.; Santos, M.; Lanillos, J.; Bechmann, N.; Peitzsch, M.; Gil-Vilarino, E.; Monteagudo, M.; Mellid, S.; Montero-Conde, C.; Cascon, A.; Leandro-Garcia, L. J.; de Velasco, G.; Duran, I.; Puente, J.; Garcia-Donas, J.; Caleiras, E.; Robledo, M.; Rodriguez-Antona, C.
10.1101/2025.01.24.632989 — cancer biology — Posted on 2025-01-27
826 Epigenetic Control of TERRA by FTSJ3 is Critical for Telomerase-Driven Cancers
Price, J. D. W.; Vizeacoumar, F. S.; Abuhussein, O.; Maranda, V.; Zhang, Y.; Adachi, H.; Kyrylenko, L.; Rangel-Pozzo, A.; Dong, H.; Gong, L. H.; Walke, P.; Ganapathysamy, A.; Denomy, C.; Freywald, T.; Dahiya, R.; Elhasasna, H.; Saxena, A.; Vizeacoumar, J.; Patel, H.; Rajamanickam, K.; Nguyen, K.; de Oliveira, D. M.; Lazell-Wright, M.; Morejon-Morales, A.; Aggarwal, A.; Xu, J. L.; Alli, N.; Munhoz, E. P.; Gao, P.; Salsman, J.; Dahiya, D.; Gonzalez-Lopez, C.; Thibault, P. A.; Levin, M.; Dellaire, G.; Jette, N.; Groot, G.; Krishnan, A.; Ahmed, S.; Eskiw, C. H.; Barakat, K.; Wu, Y.; DePinho, R. A.
10.1101/2025.01.26.634101 — cancer biology — Posted on 2025-01-27
827 Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen and Identifies Co-Treatment Strategies in Estrogen Receptor Positive Breast Cancer
Kakati, R. T.; Whitman, A. A.; Haase, S.; Szenasi, A. T.; Thai, C. H.; Brunk, E. C.; Okumu, D. O.; East, M. P.; Perou, C. M.; Johnson, G. L.; Spanheimer, P. M.
10.1101/2024.12.19.629395 — cancer biology — Posted on 2025-01-27
831 ASTRO: Automated Spatial Whole-Transcriptome RNA-Expression Workflow
Zhang, D.; Chu, Z.; Huo, Y.; Bai, Z.; Fan, R.; Lu, J.; Gerstein, M.
10.1101/2025.01.24.634814 — bioinformatics — Posted on 2025-01-27
837 Acoustic pH sensor for dynamic ultrasound imaging of cellular acidification
Terwiel, D.; Park, B. M.; Heiles, B.; Waasdorp, R.; Munoz-Ibarra, E.; Ara, T.; Gazzola, V.; Maresca, D.
10.1101/2025.01.24.634762 — bioengineering — Posted on 2025-01-27
838 DNA and RNA from the same single nucleus reveals interactions between genomic and transcriptomic landscapes in human tumor samples
Li, S.; Alexander, J.; Kendall, J.; Andrews, P.; Rose, E.; Orjuela, H.; Park, S.; Podszus, C.; Shanley, L.; Ranade, N.; Morris, P.; Stauder, D.; Bradford, D.; Ronemus, M.; Rishi, A.; Ma, R.; Donoho, D. L.; Goldberg, G. L.; Wigler, M.; Levy, D.
10.1101/2023.10.04.560973 — genomics — Posted on 2025-01-27
839 Genome assembly of Bougainvillia cf. muscus (Cnidaria: Hydrozoa)
Macias-Munoz, A.; Varney, R.; Katcher, E.; Everhart, M.; Oakley, T. H.
10.1101/2025.01.24.634790 — genomics — Posted on 2025-01-27
841 Assembly, Annotation, and Comparative Analysis of the Mitochondrial Genome of Winged Bean (Psophocarpus tetragonolobus): Insights into Evolutionary Adaptation and Codon Usage Bias
Singh, N. K.; Singh, B. K.; Kumar, P.; Pandey, A.; Kumar, S.; Bishi, S. K.; Pattynayak, A.; Bhadana, V. P.; Rakishit, S.; Tribhuvan, K. U.
10.1101/2025.01.24.634632 — genomics — Posted on 2025-01-27
842 Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer
Starble, R.; Sun, E. G.; Gbyli, R.; Radda, J.; Lu, J.; Jensen, T. B.; Sun, N.; Khudaverdyan, N.; Hu, B.; Melnick, M. A.; Zhao, S.; Roper, N.; Wang, G. G.; Song, J.; Politi, K.; Wang, S.; Xiao, A.
10.1101/2025.01.26.634826 — genetics — Posted on 2025-01-27
843 Genome-wide exploration of the transcriptional regulatory landscape in the early-diverging fungus R. microsporus reveals pervasive DNA methyl adenine regulatory network
Lax, C.; Baumgart, L. A.; Tahiri, G.; Nicolas-Munoz, N.; Zhang, Y.; Blaby, I. K.; O'Malley, R. C.; Ng, V.; Navarro, E.; Grigoriev, I. V.; Nicolas, F. E.; Garre, V.
10.1101/2025.01.24.634581 — genetics — Posted on 2025-01-27
844 Unraveling genetic load dynamics during biological invasion: insights from two invasive insect species
Lombaert, E.; Blin, A.; Porro, B.; Guillemaud, T.; Bernal, J. S.; Chang, G.; Kirichenko, N.; Sappington, T. W.; Toepfer, S.; Deleury, E.
10.1101/2024.09.02.610743 — evolutionary biology — Posted on 2025-01-27
845 Interpreting patterns of X chromosomal relative to autosomal diversity in aye-ayes(Daubentonia madagascariensis)
Terbot, J. W.; Soni, V.; Versoza, C. J.; Milhaven, M.; Calahorra-Oliart, A.; Shah, D.; Pfeifer, S. P.; Jensen, J. D.
10.1101/2025.01.25.634876 — evolutionary biology — Posted on 2025-01-27
846 The dominant lineage of Phakopsora pachyrhizi in the United States of America does not have a Brazilian origin
Ferreira, E. G. C.; Inoue, Y.; Murithi, H. M.; Nardwattanawong, T.; Cheema, J.; Grootens, R.; Paes, S. A.; Mahuku, G.; Joosten, M. H. A. J.; Hartman, G.; Yamaoka, Y.; Brommonschenkel, S. H.; van Esse, H. P.; Gupta, Y. K.
10.1101/2025.01.26.634911 — evolutionary biology — Posted on 2025-01-27
850 Attenuated adenosine mediated immune-dampening increases natural killer cell activity in early age-related macular degeneration
Nair, A. P.; Ghosh, S.; Babu, V. S.; Praveen, M.; Xin, Y.; Sahu, G. R.; Vaidya, T. A.; Debnath, J.; Raja, K.; Gadde, S. G. K.; MB, T.; Shetty, N.; Saxena, A.; Shetty, R.; Hose, S.; Deshpande, V.; Chakrabarthy, K.; Handa, J. T.; Qian, J.; Sethu, S.; Sinha, D.; Ghosh, A.
10.1101/2025.01.22.634301 — immunology — Posted on 2025-01-27
853 Proteostasis dysregulation in p.A53T-α-Synuclein iPSC-derived astrocytes exacerbates neurodegeneration in a Parkinson's disease model with Lewy-like pathology
Paschou, C.; Apokotou, O.; Kollias, A.; Charmpi, K.; Dede, S.; Samiotaki, M.; Palese, F.; Dimoula, K.; Emmanouilidou, E.; Taoufik, E.; Zurzolo, C.; Matsas, R.; Papastefanaki, F.
10.1101/2024.11.06.621638 — neuroscience — Posted on 2025-01-27
856 Unlocking the Full Potential of Nanopore Sequencing: Tips, Tricks, and Advanced Data Analysis Techniques
Meyer, D.; Goettsch, W.; Spangenberg, J.; Stieber, B.; Krautwurst, S.; Hoelzer, M.; Brandt, C.; Linde, J.; Hoener zu Siederdissen, C.; Srivastava, A.; Zarkovic, M.; Wollny, D.; Marz, M.
10.1101/2023.12.06.570356 — bioinformatics — Posted on 2025-01-27
857 Mapping Cryptic Phosphorylation Sites in the Human Proteome
Gasparotto, D.; Zanon, A.; Bonaldo, V.; Marchiori, E.; Casagranda, M.; Di Domenico, E.; Copat, L.; Asquini, T. F.; Rigoli, M.; Feltrin, S. V.; Lorenzo, N. L.; Lolli, G.; Pennuto, M.; Requena, J. R.; Stabelli, O. R.; Minervini, G.; Micheletti, C.; Spagnolli, G.; Faccioli, P.; Biasini, E.
10.1101/2024.12.03.626562 — biochemistry — Posted on 2025-01-27
858 FHY3/FAR1 transposable elements generate adaptive genetic variation in the Bassia scoparia genome
Hall, N.; Chen, J.; Saski, C. A.; Matzrafi, M.; Westra, P.; Gaines, T. A.; Patterson, E.
10.1101/2023.05.26.542497 — genomics — Posted on 2025-01-27
862 Leaf spectroscopy reveals drought response variation in Fagus sylvatica saplings from across the species' range
Kurath, D.; van Moorsel, S. J.; Klaver, J.; Voortman, T.; Siegried, B.; Bruegger, Y.-A.; Moradi, A.; Czyz, E. A.; de La Harpe, M.; Wiesenberg, G. L. B.; Schaepman, M. E.; Schuman, M. C.
10.1101/2024.07.23.604726 — ecology — Posted on 2025-01-27
863 Clearance of protein aggregates during cell division
Du, S.; Wang, Y.; Chen, B.; Xie, S.; Chan, K. Y.; Hay, D. C.; Chew, T. G.
10.1101/2024.02.10.579754 — cell biology — Posted on 2025-01-27
864 Broad diversity of human gut bacteria accessible via a traceable strain deposition system
Hitch, T. C. A.; Masson, J. M.; Pauvert, C.; Bosch, J.; Nüchtern, S.; Treichel, N.; Baloh, M.; Razavi, S.; Afrizal, A.; Kousetzi, N.; Aguirre, A. M.; Wylensek, D.; Coates, A.; Jennings, S. A. V.; Panyot, A.; Viehof, A.; Schmitz, M. A.; Stuhrmann, M.; Deis, E. C.; Bisdorf, K.; Chiotelli, M. D.; Lissin, A.; Schober, I.; Witte, J.; Cramer, T.; Riedel, T.; Wende, M.; Winter, K. A.; Amend, L.; Riva, A.; Trinh, S.; Mitchell, L.; Hartman, J.; Berry, D.; Seitz, J.; Bossert, L. C.; Grognot, M.; Allers, T.; Strowig, T.; Pester, M.; Abt, B.; Reimer, L. C.; Overmann, J.; Clavel, T.
10.1101/2024.06.20.599854 — microbiology — Posted on 2025-01-27
867 High-beta bursts in SMA mediate anticipatory muscle inhibition in a bimanual motor task
Manyukhina, V.; Abdoun, O.; Rienzo, F. D.; Barlaam, F.; Daligault, S.; Delpuech, C.; Bonnefond, M.; Schmitz, C.
10.1101/2025.01.24.634650 — neuroscience — Posted on 2025-01-27
868 FAIR assessment of MINERVA as an opportunity to foster open science and scientific crowdsourcing in systems biomedicine
Balaur, I.; Welter, D.; Rougny, A.; Inau, E. T.; Mazein, A.; Ghosh, S.; Schneider, R.; Waltemath, D.; Ostaszewski, M.; Satagopam, V.
10.1101/2024.08.28.610042 — systems biology — Posted on 2025-01-27
872 An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer.
Capitani, C.; Iorio, J.; Lastraioli, E.; Duranti, C.; Bagni, G.; Chioccioli Altadonna, G.; Colasurdo, R.; Scarpellino, G.; Fraser, S. P.; Becchetti, A.; Djamgoz, M. B. A.; Arcangeli, A.
10.1101/2024.07.02.601509 — cancer biology — Posted on 2025-01-27
873 A novel approach to tagging tubulin reveals microtubule assembly dynamics of the axoneme in Trypanosoma brucei
Abbuhl, D.; Pruzincova, M.; Stepanek, L.; Bouscasse, E.; Azevedo, R.; Matondo, M.; Varga, V.; BONNEFOY, S.; BASTIN, P.
10.1101/2025.01.27.634986 — cell biology — Posted on 2025-01-27
876 Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish
John, N.; Fleming, T.; Kolb, J.; Lyraki, O.; Vasquez-Sepulveda, S.; Parmar, A.; Kim, K.; Tarczewska, M.; Singh, K.; Marini, F.; Singh, S. P.; Falk, S.; Franze, K.; Guck, J.; Wehner, D.
10.1101/2025.01.27.635043 — neuroscience — Posted on 2025-01-27
877 TransBrain: A computational framework for translating brain-wide phenotypes between humans and mice
Huang, S.; Zhang, T.; Dong, C.; Shi, Y.; Peng, Y.; Liu, X.; Li, K.; Wang, Q.; He, Y.; Xiao, F.; Tian, X.; Xian, J.; Zhang, C.; Wu, Q.; Zou, Y.; Li, L.; Liu, B.; Wang, X.; Li, A.
10.1101/2025.01.27.635016 — neuroscience — Posted on 2025-01-27
878 Bcl-2 Oligomerizes Bax on the Mitochondrial Membrane Surface Preventing the Initial Stages of Apoptosis
Ayscough, S. E.; Clifton, L. A.; Aden, J.; Köhler, S.; Paracini, N.; Doutch, J.; Bragginton, E. C.; Leung, A. E.; Bogojevic, O.; Poon, J.-F.; Nagy, T. M.; Wacklin-Knecht, H. P.; Gröbner, G.
10.1101/2025.01.24.634681 — biophysics — Posted on 2025-01-27
880 A fluid dynamics-model system for advancing Tissue Engineering and Cancer Research studies: Dynamic Culture with the innovative BioAxFlow Bioreactor
Gramigna, G.; Liguori, F.; Filippini, L.; Mastantuono, M.; Pistillo, M.; Scamarcio, M.; Lisi, A.; Falvo D'Urso Labate, G.; Ledda, M.
10.1101/2025.01.24.634745 — bioengineering — Posted on 2025-01-27
882 The cause-effect conundrum of local-scale site and soil factors in acute oak decline (AOD)
Shaw, L. J.; Rabiey, M.; Garcia, M. S. J.; Clarke, T.; Broome, A.; Corbett, L. J.; Booth, O. R.; Barrett, G. A.; Preston, G. M.; Barsoum, N.; Schonrogge, K.; Jackson, R. W.; Ray, D.
10.1101/2025.01.24.634765 — ecology — Posted on 2025-01-27
884 Tunneling CARs: Increasing CAR T tumor infiltration through the overexpression of MMP7 and SPP1
Van Pelt, S. N.; White, M.; Tat, C.; Hooper, D.; Talbot, L.; Fernandes, R.; Rooney, C.; Omer, B.
10.1101/2025.01.24.634731 — immunology — Posted on 2025-01-27
885 A brainstem map of orofacial rhythms
Kaku, H.; Liu, L. D.; Gao, R.; West, S.; Liao, S.-M.; Finkelstein, A.; Kleinfeld, D.; Thomas, A.; Tipparaju, S. L.; Svoboda, K.; Li, N.
10.1101/2025.01.27.635041 — neuroscience — Posted on 2025-01-27
886 CFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease
Dos Reis, D. C.; Jin, J.; Santos, A.; Muiler, C.; Zagoren, E.; Donnelley, M.; Parsons, D.; Cmielewski, P.; Reyne, N.; McCarron, A.; Smith, Z.; Sumigray, K.; Ameen, N. A.
10.1101/2025.01.24.634747 — physiology — Posted on 2025-01-27
888 Single Cell Spatial Transcriptomics Reveals Immunotherapy-Driven Bone Marrow Niche Remodeling in AML
Gui, G.; Bingham, M. A.; Herzog, J. R.; Wong-Rolle, A.; Dillon, L. W.; Goswami, M.; Martin, E.; Reeves, J.; Kim, S.; Bahrami, A.; Degenhardt, H.; Zaki, G.; Divakar, P.; Schrom, E. C.; Calvo, K.; Hourigan, C. S.; Hansen, K. D.; Zhao, C.
10.1101/2025.01.24.634753 — cancer biology — Posted on 2025-01-27
889 Atomic scale description of the allosteric coupling between a lipid bilayer and a membrane protein
Fourel, C.; Gautier, Y.; Pozza, A.; Giraud, F.; Point, E.; Le Bon, C.; Moncoq, K.; Stirnemann, G.; Henin, J.; Lescop, E.; Catoire, L. J.
10.1101/2025.01.24.634742 — biophysics — Posted on 2025-01-27
892 SpaIM: Single-cell Spatial Transcriptomics Imputation via Style Transfer
Li, B.; Tang, Z.; Budhkar, A.; Liu, X.; Zhang, T.; Yang, B.; Su, J.; Song, Q.
10.1101/2025.01.24.634756 — bioinformatics — Posted on 2025-01-27
895 Caudata macrogenetics: Species range size predicts intraspecific genetic variation in global salamanders
Amador, L.; Wiley, D. L. F.; Arroyo-Torres, I.; McDaniels, C. X.; Rosario-Sanchez, E. O.; Farmer, H.; Bradley, H.; Erdmann, J.; Pelletier, T. A.; Barrow, L. N.
10.1101/2025.01.24.634750 — evolutionary biology — Posted on 2025-01-27
897 Cryptocercus genomes expand knowledge of adaptations to xylophagy and termite sociality
Jones, A. R.; Mikhailova, A. A.; Aumont, C.; Berger, J.; Bornberg-Bauer, E.; Liu, C.; He, S.; Wang, Z.; Winkler, S.; Legendre, F.; McMahon, D. P.; Harrison, M. C.
10.1101/2025.01.24.634722 — evolutionary biology — Posted on 2025-01-27
899 Centriole Loss in Embryonic Development Disrupts Axonal Pathfinding and Muscle Integrity
Gonzalez, B.; Selles-Altes, J.; Pla-Parron, J.; Castro-Ribera, J.; Araujo, S. J.
10.1101/2025.01.26.634909 — cell biology — Posted on 2025-01-27
901 Optimized vectors for genetic engineering of Aureobasidium pullulans
Colarusso, A.; Williams, A.; Gladfelter, A. S.; Wirshing, A. C. E.; Lew, D. J.
10.1101/2025.01.25.634885 — cell biology — Posted on 2025-01-27
902 LAM/TREM2+ macrophages release extracellular vesicles and extracellular lipid droplets which modulate the phenotype of recipient macrophages and homeostasis of skeletal muscle cells
Tacconi, S.; Giudetti, A. M.; Blangero, F.; Meugnier, E.; El-jaafari, A.; Longo, S.; Angile, F.; Fanizzi, F. P.; Canaple, L.; Jalabert, A.; Errazuriz-Cerda, E.; Cassin, C.; Zuccotti, M.; Alfieri, A.; Da Silva, C. C.; Brun, C.; Gillet, B.; Hughes, S.; Rieusset, J.; Vidal, H.; dini, l.; Rome, S.
10.1101/2025.01.26.634912 — cell biology — Posted on 2025-01-27
903 ECD functions as a novel RNA-binding protein to regulate mRNA splicing
Raza, M.; Rajan, A. R.; Kalluchi, A.; Saleem, I.; Kennedy, B. B.; Bhakat, K. K.; Band, H.; Rowley, M. J.; Band, V.
10.1101/2025.01.24.634785 — cell biology — Posted on 2025-01-27
906 Morphology and connectivity of retinal horizontal cells in two avian species
Guenther, A.; Balaji, V.; Leberecht, B.; Forst, J. J.; Rotov, A. Y.; Woldt, T.; Abdulazhanova, D.; Mouritsen, H.; Dedek, K.
10.1101/2025.01.27.634460 — neuroscience — Posted on 2025-01-27
907 Neural sensitivity to radial frequency patterns in the visual cortex of developing macaques
Rodriguez Deliz, C. L.; Lee, G.; Bushnell, B.; Majaj, N.; Movshon, J. A.; Kiorpes, L.
10.1101/2025.01.27.634810 — neuroscience — Posted on 2025-01-27
913 Centromeres in the thermotolerant yeast K. marxianusmediate attachment to a single microtubule
Barrero, D. J.; Hedouin, S.; Mao, Y.; Asbury, C. L.; Stergachis, A.; O'Toole, E.; Biggins, S.
10.1101/2025.01.24.634737 — cell biology — Posted on 2025-01-27
914 APOE-ϵ4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer's disease
Bhattarai, P.; Yilmaz, E.; Cakir, E. O.; Yuceer Korkmaz, H.; Lee, A. J.; Ma, Y.; Celikkaya, H.; Cosacak, M. I.; Haage, V.; Wang, X.; Nelson, N.; Lin, W.; Zhang, Y.; Nuriel, T.; Juelich, D.; Is, O.; Scott, H.; de Jager, P.; Fisher, E.; Tubessing, K.; Teich, A. F.; Bertucci, T.; Temple, S.; Ertekin-Taner, N.; Vardarajan, B. N.; Mayeux, R.; Kizil, C.
10.1101/2025.01.24.634732 — cell biology — Posted on 2025-01-27
915 N-terminal modification of Histone H3 inhibits H3K27M-mediated loss of H3K27 trimethylation
Poux, N.; Zhang, D. F.; Kebede, A. F.; Gainey, I.; Famous, O. E.; Beroukhim, R.; Bandopadhayay, P.
10.1101/2025.01.24.634760 — cell biology — Posted on 2025-01-27
917 Cancer cells transfer invasive properties through microRNAs contained in collagen-tracks
Normand, L.; Rouyer, L.; Richard, E.; Allain, N.; Giraud, J.; Di-Tommaso, S.; Dourthe, C.; Raymond, A. A.; Dupuy, J.-W.; Moreau, K.; Iggo, R.; McGrogan, G.; Dugot-Senant, N.; Bouter, A.; Tan, S.; Favereaux, A.; Moreau, V.; Luco, R.; Ros, M.; SALTEL, F.
10.1101/2025.01.25.634857 — cell biology — Posted on 2025-01-27
919 The TARZN complex binds de novo enhancer mutations and promotes oncogenic expression in T-ALL
Zaal Anuar, N.; Goh, C. Y.; Chua, B. H.; Tan, S. H.; Costa, J. R.; Mansour, M. R.; Sanda, T.; Kappei, D.
10.1101/2025.01.24.634708 — cell biology — Posted on 2025-01-27
920 Glycan-Mediated Mechanosensing Regulates Megakaryocyte-Biased Hematopoietic Stem Cell Subsets.
Roisman, A.; Rivadeneyra, L.; Conroy, L.; Lee-Sundlov, M. M.; Weich, N.; Glabere, S.; Zheng, S.; Rosenbalm, K. E.; Zogg, M.; Steinhardt, G.; Veltri, A. J.; Lau, J. T.; Gu, T.; Weiler, H.; Sun, R. C.; Hoffmeister, K.
10.1101/2025.01.25.634886 — cell biology — Posted on 2025-01-27
921 NCBP2-AS2 is a mitochondrial microprotein, regulates energy metabolism and neurogenesis, and is downregulated in Alzheimer's disease
Popova, S.; Bhattarai, P.; Yilmaz, E.; Lascu, D.; Kuo, J.-H.; Erdem, G.; Coban, B.; Michling, J.; Cosacak, M. I.; Tayran, H.; Kurth, T.; Schambony, A.; Buchholz, F.; Gentzel, M.; Kizil, C.
10.1101/2025.01.25.634884 — cell biology — Posted on 2025-01-27
922 Reduced systemic autophagy by simultaneous loss of ATG4B, ATG4C and ATG4D leads to accelerated aging in mice
Martinez-Garcia, G. G.; Suarez, M. F.; Rodriguez-Santamaria, M. d. M.; Roiz-Valle, D.; Barcena, C.; Corrochano-Ruiz, A.; Tamargo-Gomez, I.; Mayoral, P.; Astudillo, A.; Sveen, C.; Engedal, N.; Lopez-Otin, C.; F. Fernandez, A.; Marino, G.
10.1101/2025.01.25.634746 — cell biology — Posted on 2025-01-27
923 Stable lentiviral-mediated expression of Cytochrome P450 2D6 in HepaRG cells: New means for in vitro assessment of xenobiotic biotransformation and cytotoxicity
Coppens-Exandier, H.; Mackanga, F.; Darde, T.; Bonhomme, C.; Ribault, C.; Gicquel, T.; Pelletier, R.; Roshchina, F.; Schaefer, E.; Chesne, C.; Jamin, A.; Corlu, A.; Loyer, P.
10.1101/2025.01.25.634872 — cell biology — Posted on 2025-01-27
924 HMG box-containing protein 1 (HBP1) prevents pancreatic injury in experimental pancreatitis but accelerates pancreatic neoplasia progression
lee, S.-W.; Ekstrom, T.; Manalo, E.; Ye, S.; Berry, M.; Grygoryev, D.; Szczepaniak, M.; Marmolejo, C. O.; Haverlack, S.; Lee, J.; Shah, V. M.; Keith, D.; Muschler, J. L.; Chin, K.; Sears, R. C.; Weisberg, S. P.; Morgan, T. K.; kim, j.
10.1101/2025.01.24.634817 — cell biology — Posted on 2025-01-27
925 AGO1 interacts with NEAT1 lncRNA and impacts nuclear compartments
Shuaib, M.; Mannen, T.; Yamazaki, T.; Adroub, S. A.; Ghosheh, Y.; Albawardi, W.; Hirose, T.; Orlando, V.
10.1101/2025.01.26.634929 — cell biology — Posted on 2025-01-27
926 Basigin Links Altered Skeletal Stem Cell Lineage Dynamics with Glucocorticoid-induced Bone Loss and Impaired Angiogenesis
Ambrosi, T. H.; Morales, D.; Chen, K.; Hunt, E.; Weldon, K. C.; Maifeld, A. N.; Chavez, F. I.; Wang, Y.; Murphy, M. P.; Cressman, A.; Wheeler, E. E.; Saiz, A.; Leach, J. K.; Fierro, F.; Chan, C. K.; Lane, N. E.
10.1101/2025.01.25.634887 — cell biology — Posted on 2025-01-27
927 Schistosoma mansoni-induced host immunopathology is gut microbiota dependent
Kildemoes, A. M. O.; Schramm, G.; Pakkenberg, B.; Krause, F.; Rasmussen, M. A.; Friis Hansen, C.; Kot, W.; Jensen, A.; Wawrcyniak, J.; Griffin, J.; Wilson, S.; Skov, S.; Hansen, A. K.; Nielsen, D. S.; Vennervald, B. J.
10.1101/2025.01.24.634684 — immunology — Posted on 2025-01-27
928 Alpha-Synuclein co-pathology in Alzheimer's Disease drives tau accumulation
Struebing, F. L.; De Vecchi, T.; Widmann, J.; Song, X.; Fierli, F.; Ruf, V.; Arzberger, T.; Roeber, S.; Koeglsperger, T.; Windl, O.; Haass, C.; Winkelmann, J.; Herms, J.
10.1101/2025.01.24.634706 — neuroscience — Posted on 2025-01-27
932 Flickering white light stimulation at 60 Hz induces strong, widespread neural entrainment and synchrony in healthy subjects
Alamalhoda, M.; Leesch, F.; Giovanetti, F.; Dunne, E.; Pilloni, G.; Caffrey, M.; OKeeffe, J.; Venturino, A.; Ferretti, M. T.
10.1101/2025.01.27.634699 — neuroscience — Posted on 2025-01-27
933 Neuronal Activity-Dependent Gene Dysregulation in C9orf72 i3 Neuronal Models of ALS/FTD Pathogenesis
Ghaffari, L. T.; Welebob, E.; Boehringer, A.; Cyliax, K.; Pasinelli, P.; Trotti, D.; Haeusler, A. R.
10.1101/2025.01.27.632228 — neuroscience — Posted on 2025-01-27
935 CDP-DAG synthases regulate plant growth and broad-spectrum disease resistance
Tan, R.; Sha, G.; Gong, Q.; Yang, L.; Wei, Y.; Liu, X.; Li, Y.; Cheng, J.; Du, X.; Xue, H.; Li, Q.; Luo, J.; Li, G.
10.1101/2025.01.24.634677 — plant biology — Posted on 2025-01-27
938 Multi-modal analysis of satellite cells reveals early impairments at pre-contractile stages of myogenesis in Duchenne muscular dystrophy
Franzmeier, S.; Chakraborty, S.; Mortazavi, A.; Stöckl, J. B.; Pfarr, N.; Sabass, B.; Fröhlich, T.; Kaufhold, C.; Stirm, M.; Wolf, E.; Schlegel, J.; Matiasek, K.
10.1101/2025.01.24.634739 — pathology — Posted on 2025-01-27
944 Met-ID: An Open-Source Software for Comprehensive Annotation of Multiple On-Tissue Chemical Modifications in MALDI-MSI
Bjärterot, P.; Nilsson, A.; Shariatgorji, R.; Vallianatou, T.; Kaya, I.; Svenningsson, P.; Käll, L.; Andren, P. E.
10.1101/2025.01.24.634674 — bioinformatics — Posted on 2025-01-27
946 Bayesian optimization of cortical neuroprosthetic vision using perceptual feedback
Kucukoglu, B.; Soo, L.; Leeftink, D.; Grani, F.; Soto Sanchez, C.; Guclu, U.; van Gerven, M.; Fernandez, E.
10.1101/2025.01.24.634528 — bioengineering — Posted on 2025-01-27
947 Loss-of-function mutations in ASIP and MC1R are associated with coat colour variation in marsupials.
Sauermann, R.; Fancourt, B.; Faulkner, T.; Shute, H.; Reid, D.; Pask, A. J.; Feigin, C. Y.
10.1101/2025.01.22.633987 — genomics — Posted on 2025-01-27
949 A pan-respiratory virus attachment inhibitor with high potency in human airway models and in vivo
Mathez, G.; Jacob Silva, P.; Carlen, V.; Deloizy, C.; Prompt, C.; Hubart, A.; Rocha-Pereira, J.; Galloux, M.; Le Goffic, R.; Stellacci, F.; Cagno, V.
10.1101/2025.01.25.634704 — microbiology — Posted on 2025-01-27
951 Lipid hydrogen isotope compositions primarily reflect growth water in the model archaeon Sulfolobus acidocaldarius
Harris, C. M.; Kopf, S.; Rhim, J. H.; Cobban, A.; Elling, F. J.; Feng, X.; McFarlin, J.; Weber, Y.; Zhang, Y.; Zhou, A.; Batther, H.; Pearson, A.; Leavitt, W. D.
10.1101/2024.10.24.620110 — microbiology — Posted on 2025-01-27
952 β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury
Prevel, R.; Pernet, E.; Tran, K. A.; Sadek, A.; Sadeghi, M.; Lapshina, E.; Jurado, L.; Kristof, A. S.; Moumni, M.; Poschmann, J.; Divangahi, M.
10.1101/2024.09.02.610842 — immunology — Posted on 2025-01-27
953 Vertical transmission of chronic wasting disease in free-ranging white-tailed deer populations
Sandoval, A.; Nalls, A. D.; McNulty, E. D.; Denkers, N. D.; Trujillo, D. D.; Olmsted, Z.; Barton, E.; Ballard, J. R. D.; Grove, D. M.; Dennison, J.; Stilwell, N.; Cleveland, C.; Crum, J.; Ruder, M.; Mathiason, C. K.
10.1101/2025.01.24.634834 — neuroscience — Posted on 2025-01-27
954 Deciphering Multiway Multiscale Brain Network Connectivity:Insights from Birth to 6 Months
Li, Q.; Fu, Z.; Walum, H.; Seraji, M.; Bajracharya, P.; Calhoun, V.; Shultz, S.; Iraji, A.
10.1101/2025.01.24.634772 — neuroscience — Posted on 2025-01-27
955 Transcription driven repurposing of cardiotonic steroids for Lithium treatment of severe depression
Killick, R.; Hooper, C.; Fernandes, C.; Elliott, C.; Aarsland, D.; Kjosavik, S. R.; Osterhus, R. D.; Williams, G.
10.1101/2025.01.24.634703 — neuroscience — Posted on 2025-01-27
957 An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m6A-mediated epi-transcriptomic dysregulation underlying synaptic dysfunction
Guo, Z.; Lu, L.; Sarkar, A. K.; Dao, L.; Liu, Y.; Ma, C.; Thwin, P. H.; Chang, X.; Yoshida, G.; Li, A.; Wang, C.; Westerkamp, G.; Schmitt, L.; Chelsey, M.; Stephanie, M.; Zhao, Y.; Liu, Y.; Wang, X.; Zhu, L.-Q.; Liu, D.; Tchieu, J.; Miyakoshi, M.; Zhu, H.; Gross, C.; Pedapati, E.; Salomonis, N.; Erickson, C.
10.1101/2024.10.14.618205 — neuroscience — Posted on 2025-01-27
958 Effects of systemic oxytocin and beta-3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet-induced obese rats
Slattery, J. D.; Rambousek, J. R.; Tsui, E.; Honeycutt, M. K.; Goldberg, M.; Graham, J. L.; Wietecha, T. A.; Wolden-Hanson, T.; Williams, A. L.; O'Brien, K. D.; Havel, P. J.; Blevins, J. E.
10.1101/2024.09.27.615550 — neuroscience — Posted on 2025-01-27
961 Human and Mouse Models for Kabuki Syndrome Reveal Increase in Inhibitory Synapse Development.
Knopp, J.; Weaver, A.; Miller, S.; Nomura, T.; Whitlark, A.; Swantkowski, J.; Noble, A.; Nam, S.; Hutson, K.; Bergqvist-Patzke, J.; Contractor, A.; Patzke, C.
10.1101/2024.10.04.616738 — neuroscience — Posted on 2025-01-27
962 LGBTQ+ realities in the biological sciences
Cooper, K. M.; Busch, C. A.; Accorsi, A.; Applewhite, D. A.; Bhanderi, P. B.; da Rocha-Azevedo, B.; Roy, A. D.; Campanale, J. P.; Chang, F.; Chipuk, J. E.; Ligon, L. A.; Luxton, G. G.; Graham, A. J.; Hochman-Mendez, C.; Ozugergin, I.; Park, Z. M.; Thomas, C. M.; Valm, A. M.; Zhu, H.; Alvania, R. S.
10.1101/2025.01.24.634486 — scientific communication and education — Posted on 2025-01-27
963 A comparative analysis between two flax varieties indicates lignan-mediated salt stress adaptiveness
Debnath, A. J.; Harencar, L.; Kucka, M.; Kovar, M.; Ivanisova, E.; Mistrikova, V.; Gazo, J.; Razna, K.
10.1101/2024.10.10.617604 — plant biology — Posted on 2025-01-27
964 Targeting Runx1 protects against heart failure with preserved ejection fraction
Elbassioni, A. A. M.; Raheem, A. A.; Song, J.; Johnston, A. S.; Trivett, C.; Lin, H.; Zhang, H.; Bradley, A.; Higgins, E.; Mooney, L.; Koay, Y. C.; O'Toole, D.; Herzyk, P.; Nixon, C.; Blyth, K.; O'Sullivan, J. F.; Lang, N. N.; Berry, C.; Braun, T.; Schiattarella, G. G.; Giacca, M.; McBride, M. W.; Nicklin, S. A.; Cameron, E. R.; Loughrey, C. M.; MacDonald, E. A.
10.1101/2025.01.24.634831 — physiology — Posted on 2025-01-27
965 Epigenetic small molecule screening identifies a new HDACi compound for ameliorating Duchenne muscular dystrophy
Louie, K. W.; Hasegawa, E. H.; Farr, G. H.; Ignacz, A.; Paguio, A.; Maenza, A.; Paquette, A. G.; Henry, C.; Maves, L.
10.1101/2025.01.24.634796 — pharmacology and toxicology — Posted on 2025-01-27
966 Investigating the structural effects of anti-thrombin anticoagulant aptamers on activation of human prothrombin
Troisi, R.; Cangiano, A.; Cowieson, N.; Spiridonova, V.; Del Vecchio, P.; Paduano, L.; Sica, F.
10.1101/2025.01.24.634711 — biophysics — Posted on 2025-01-27
971 Solution biophysics identifies lipid nanoparticle non-sphericity, polydispersity, and dependence on internal ordering for efficacious mRNA delivery
Padilla, M.; Shepherd, S. J.; Hanna, A. R.; Kurnik, M.; Zhang, X.; Chen, M.; Byrnes, J.; Yamagata, H.; Ricciardi, A.; Joseph, R.; Mrksich, K.; Issadore, D.; Gupta, K.; Mitchell, M.
10.1101/2024.12.19.629496 — bioengineering — Posted on 2025-01-27
972 ST-FFPE-mIF: Integrating Spatial Transcriptomics and Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tissues Using Stereo-seq
Zhang, X.; Zhang, M.; Xu, Y.; Song, Y.; Yang, X.; Wu, Y.; Zhao, X.; Ran, D.; Liu, X.; Huang, H.; Lei, W.; Li, H.; Zhang, Y.; Xi, F.; Li, G.; Liu, X.; Xu, L.; Chen, A.; Liao, S.; Zhang, J. j.
10.1101/2025.01.24.634655 — biochemistry — Posted on 2025-01-27
973 Discovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG
Zhang, Z.; Liu, Y.-K.; Luo, Z.; Wu, M.-J.; Evans, C. N.; Qu, Z.; Xue, F.; Zhang, Z.-Y.; Parkinson, E. I.; Bardeesy, N.; Tao, W. A.
10.1101/2025.01.24.634716 — biochemistry — Posted on 2025-01-27
974 Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis
Shimogawa, M.; Li, M.-H.; Park, G. S. H.; Ramirez, J.; Lee, H.; Watson, P.; Sharma, S.; Lin, Z.; Peng, C.; Christianson, D. W.; Eliezer, D.; Rhoades, E.; Petersson, E. J.
10.1101/2025.01.21.634178 — biochemistry — Posted on 2025-01-27
975 Structural Basis of Lipid Membrane Binding by Human Ferlins
Cretu, C.; Chernev, A.; Szabo, C. Z. K.; Pena, V.; Urlaub, H.; Moser, T.; Preobraschenski, J.
10.1101/2025.01.25.634844 — biochemistry — Posted on 2025-01-27
979 Dietary protein source mediates colitis pathogenesis through bacterial modulation of bile acids
Gray, S. M.; Wood, M. C.; Mulkeen, S. C.; Ahmed, S.; Thaker, S. D.; Chen, B.; Sander, W. R.; Bibeva, V.; Zhang, X.; Yang, J.; Herzog, J. W.; Zhang, S.; Dogan, B.; Simpson, K. W.; Sartor, R. B.; Montrose, D. C.
10.1101/2025.01.24.634824 — microbiology — Posted on 2025-01-27
980 Neuroimaging and plasma biomarker differences and commonalities in Lewy body dementia subtypes
Hannaway, N.; Zarkali, A.; Bhome, R.; Dobreva, I.; Thomas, G. E. C.; Veleva, E.; Gorostiaga Belio, I.; Tucker, K.; Heslegrave, A.; Zetterberg, H.; Weil, R. S.
10.1101/2025.01.24.634687 — neuroscience — Posted on 2025-01-27
981 High-beta bursts in SMA mediate anticipatory muscle inhibition in a bimanual motor task
Manyukhina, V.; Bonnefond, M.; Abdoun, O.; Rienzo, F. D.; Barlaam, F.; Daligault, S.; Delpuech, C.; Schmitz, C.
10.1101/2025.01.24.634650 — neuroscience — Posted on 2025-01-27
983 ERGA-BGE genome of Cheirolophus tagananensis: an IUCN endangered shrub endemic to the Canary Islands
Pellicer, J.; Garnatje, T.; Vitales, D.; Hidalgo, O.; Valles, J.; Garcia-Fernandez, A.; Santos-Guerra, A.; Bohne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory Team, ; Wellcome Sanger Institute Scientific Operations: Sequencing Operations, ; Wellcome Sanger Institute Tree of Life Core Informatics Team, ; Thomas, A.; Jackson, B.; Wood, J. M.; Howe, K.; Blaxter, M.; McCarthy, S.; Bortoluzzi, C.
10.1101/2025.01.24.634661 — genomics — Posted on 2025-01-26
984 Genomic characterisation of Listeria monocytogenes isolated from normally sterile human body fluids in Lithuania from 2016 to 2021
Slavinska, A.; Jauneikaite, E.; Meskyte, U.; Kirkliauskiene, A.; Misevic, A.; Petrutiene, A.; Kuisiene, N.
10.1101/2025.01.23.633655 — genomics — Posted on 2025-01-26
985 Functional characterization of immune cells in a cnidarian reveals an ancestral antiviral program
Kozlovski, I.; Sharoni, T.; Levy, S.; Jaimes-Becerra, A.; Talice, S.; Kwak, H.-J.; Aleshkina, D.; Grau-Bove, X.; Karmi, O.; Rosental, B.; Sebe-Pedros, A.; Moran, Y.
10.1101/2025.01.24.634691 — evolutionary biology — Posted on 2025-01-27
987 Emergence of high-connectivity states before epileptic seizures: Multi-patient validation, physiological correlates, and network modeling
MEDINA LEANDRO, B. N.; Tauste, A.; Vila-Vidal, M.; Tost, A.; Khawaja, M.; Carreno, M.; Roldan, P.; Rumia, J.; Centeno, M.; Conde, E.; Donaire, A.
10.1101/2025.01.24.634461 — neuroscience — Posted on 2025-01-27
989 Isostere 18F-protein post-translational editing enables dynamic tracking of neurodegeneration biomarkers
Yang, N.; Poh, A. W. J.; Giltrap, A. M.; Isenegger, P. G.; Sap, J. B. I.; Ford, J.; Auchynnikava, T.; Tan, K. V.; Able, S.; Levin, N.; Davy, M.; Josephson, B.; Yu, Y.; Miner, M. W. G.; Helin, J. S.; Kovacs, L.; Aarnio, R.; Rajala, N. A.; Tredwell, M.; Mohammed, S.; Baldwin, A. J.; Dickens, A. M.; Vallis, K. A.; Kuhle, J.; McGowan, D. R.; Airaksinen, A. J.; Anthony, D. C.; Leppert, D.; Gouverneur, V.; Davis, B. G.
10.1101/2025.01.26.634877 — synthetic biology — Posted on 2025-01-26
990 Isolation of a novel plant growth-promoting Dyella sp. from a Danish natural soil
Dethier, L.; Jespersen, J. R. P.; Lloyd, J.; Pupi, E.; Zhou, W.; Liu, F.; Bai, Y.; Halkier, B. A.; Xu, D.
10.1101/2025.01.24.634660 — plant biology — Posted on 2025-01-26
991 The receptor-like kinases BIR1 and BIR3 modulates antiviral resistance by different mechanisms
Robinson, C.; Guzman-Benito, I.; Sede, A. R.; Elvira-Gonzalez, L.; Hua, C.; Ciska, M.; Nurnberger, T.; Heinlein, M.; Llave, C.
10.1101/2025.01.24.634664 — plant biology — Posted on 2025-01-26
992 Fasting-induced hepatic gluconeogenesis is compromised in Anxa6-/- mice
Alvarez-Guaita, A.; Bernaus-Esque, M.; Blanco-Munoz, P.; Liu, Y.; Sebastian, D.; Meneses-Salas, E.; Nguyen, M. K. L.; Zorzano, A.; Tebar, F.; Enrich, C.; Grewal, T.; Rentero Alfonso, C.
10.1101/2025.01.24.634638 — physiology — Posted on 2025-01-26
993 JNK2 pathway in colonocytes enhances gut barrier integrity in response to microbial acetate.
Chongtham, C.; Biswas, T.; Kumari, N.; Kar, R.; Singh, J.; Chattopadhyay, S.; S, J.; Pant, A.; Patil, V. S.; Arimbasseri, G. A.
10.1101/2025.01.24.634634 — physiology — Posted on 2025-01-26
997 The modification of DNA with indole-linked nucleotides alters its sensitivity to enzymatic cleavage
Lingala, S.; Fisiuk, A.; Stephen, M.; Mohanrao, R.; Klingsberg, J.; Vecchioni, S.; Volvovitz, E.; Rozhkov, S.; Mallikaratchy, P.
10.1101/2025.01.26.634936 — biochemistry — Posted on 2025-01-26
998 Distal mutations in a designed retro-aldolase alter loop dynamics to shift and accelerate the rate-limiting step
Hunt, S. E.; Klaus, C.; John, A. E.; Zarifi, N.; Martinez, A.; Feixas, F.; Garcia-Borras, M.; Thompson, M. C.; Chica, R. A.
10.1101/2025.01.26.634918 — biochemistry — Posted on 2025-01-26
1001 Reaching reproduction in a large carnivore: role of early environment and intrinsic traits
Auclair, L.; Di Bernardi, C.; Sand, H.; Akesson, M.; Zimmermann, B.; Flagstad, O.; Wabakken, P.; Wikenros, C.
10.1101/2025.01.24.634662 — ecology — Posted on 2025-01-26
1002 Targeted delivery of mRNA to the heart via extracellular vesicles or lipid nanoparticles
Nawaz, M.; Tangruksa, B.; Heydarkhan-Hagvall, S.; Kohl, F.; Gonzalez-King Garibotti, H.; Jing, Y.; Payandeh, Z.; Reyahi, A.; Jennbacken, K.; Wiseman, J.; Hultin, L.; Lindfors, L.; Synnergren, J.; Valadi, H.
10.1101/2025.01.25.634881 — molecular biology — Posted on 2025-01-26
1003 Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation
Bridgers, J. B.; Carlstrom, A.; Sherpa, D.; Couvillion, M. T.; Rovsnik, U.; Gao, J.; Wan, B.; Shao, S.; Ott, M.; Churchman, L. S.
10.1101/2025.01.26.634913 — molecular biology — Posted on 2025-01-26
1005 Evaluation of the role of whiB6 and kdpDE in the dominant multidrug resistant clone Mycobacterium tuberculosis B0/W148
Bonnet, I.; Orgeur, M.; Brossier, F.; Sayes, F.; Frigui, W.; Madacki, J.; Varet, H.; Chauffour, A.; Aubry, A.; Veziris, N.; Sougakoff, W.; Brosch, R.; Tournebize, R.
10.1101/2025.01.26.634749 — microbiology — Posted on 2025-01-26
1006 Bioenergetic reprogramming of macrophages reduces drug tolerance in Mycobacterium tuberculosis
Yadav, V.; Sahoo, S.; Malhotra, N.; Mishra, R.; Rajmani, R. S.; Shanmugam, S.; Shandil, R.; Narayanan, S.; Thacker, V. V.; Jolly, M. K.; Seshasayee, A. S. N.; Singh, A.
10.1101/2025.01.24.634842 — microbiology — Posted on 2025-01-26
1007 ViFIT-assisted Histopathology: From H&E Style Standardization to Virtual Fiber Image Transformation
Wang, S.; Zhang, X.; Wang, X.; Lv, C.; Han, X.; Lin, X.; Kang, D.; Lin, R.; Hu, L.; Huang, F.; Liu, W.; Chen, J.
10.1101/2025.01.24.634654 — pathology — Posted on 2025-01-26
1008 Two CTCF motifs impede cohesin-mediated DNA loop extrusion
Barth, R.; Janissen, R.; Muras, L.; van der Torre, J.; Litos, G.; van der Sluis, E.; van der Graaf, A.; Davidson, I. F.; Peters, J.-M.; Dekker, C.
10.1101/2025.01.26.634934 — biophysics — Posted on 2025-01-26
1011 RegFormer: A Single-Cell Foundation Model Powered by Gene Regulatory Hierarchies
Hu, L.; Qiu, P.; Qin, H.; Cao, L.; Jiang, W.; Zhang, Y.; Chen, Q.; Shang, Y.; Xia, T.; Deng, Z.; Xu, X.; Fang, S.; Li, Y.; Zhang, Y.
10.1101/2025.01.24.634217 — bioinformatics — Posted on 2025-01-26
1012 Durable reconstitution of sinonasal epithelium by transplant of CFTR gene corrected airway stem cells
Bravo, D. T.; Vaidyanathan, S.; Baker, J.; Sinha, V.; Tsai, E.; Roozdar, P.; Kong, W. W.; Atkinson, P. J.; Patel, Z. M.; Hwang, P. H.; Rao, V. K.; Negrin, R. S.; Wine, J. J.; Milla, C.; Sellers, Z. M.; Desai, T. J.; Porteus, M.; Nayak, J. V.
10.1101/2025.01.24.634776 — bioengineering — Posted on 2025-01-26
1014 The biochemical function of bivalent aptamer assemblies against B-cell markers CD19 and CD20
Cen, Y. N.; Williams, N. B.; Di Siervi, N.; Chen, L.; Seneviratne, P.; Kreitzer, G.; Cerchietti, L.; Mallikaratchy, P.
10.1101/2025.01.26.634939 — biochemistry — Posted on 2025-01-26
1015 Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut
Lamberte, L. E.; Darby, E. M.; Kiu, R. K. O.; Moran, R. A.; Acuna-Gonzalez, A.; Sim, K.; Shaw, A. G.; Kroll, J. S.; Belteki, G.; Clarke, P.; Felgate, H. M.; Webber, M. A.; Rowe, W.; Hall, L. J.; van Schaik, W.
10.1101/2025.01.25.634871 — microbiology — Posted on 2025-01-26
1018 Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignancies
Lin, Y.; Xiao, Z.; Hu, F.; Zheng, X.; Zhang, C.; Wang, Y.; Liu, Y.; Huang, D.; Wang, Z.; Xia, C.; Weng, Q.; Zhang, L.; Zhao, Y.; Qi, H.; Shen, Y.; Chen, Y.; Zhang, F.; Wu, J.; Liu, P.; Xu, J.; Liu, L.; Zhu, Y.; Zhang, J.; Qian, W.; Liang, A.; Zhu, X.; Wang, T.; Zhang, M.; Wang, J.
10.1101/2025.01.23.634617 — cancer biology — Posted on 2025-01-26
1022 Identification of QTL for reproductive success under heat stress conditions through a tomato MAGIC population
Lin, Y.-P.; Hussain, E.; Hsu, Y.-C.; Lin, C.-Y.; Chen, Y.-S.; Hsu, L.-H.; Hung, C.-Y.; Huang, S.-m.; Yen, J.-Y.; Eybishitz, A.; Hanson, P.; Kang, S. W.; Hoshikawa, K.
10.1101/2025.01.23.634636 — genomics — Posted on 2025-01-26
1024 Combined Central and Peripheral Nerve Stimulation Improves Functional Recovery of Mixed Peripheral Nerve Injury in a Rat Forelimb Model
Eftekari, S. C.; Yoon, Y.-C.; Chen, R. C.-H.; Nicksic, P. J.; Donnelly, D. T.; Jesch, A.; Shaffrey, E. C.; Zeng, W.; Ludwig, K. A.; Poore, S. O.; Vakoc, B. J.; Suminski, A.; Dingle, A. M.
10.1101/2025.01.26.634922 — neuroscience — Posted on 2025-01-26
1025 Striatal cell-type specific stability and reorganization underlying agency and habit
Malvaez, M.; Liang, A.; Hall, B. S.; Giovanniello, J. R.; Paredes, N.; Gonzalez, J. Y.; Blair, G. J.; Sias, A. C.; Murphy, M. D.; Guo, W.; Wang, A.; Singh, M.; Griffin, N. K.; Bridges, S. P.; Wiener, A.; Pimenta, J. S.; Holley, S. M.; Cepeda, C.; Levine, M. S.; Blair, H. T.; Wikenheiser, A. M.; Wassum, K. M.
10.1101/2025.01.26.634924 — neuroscience — Posted on 2025-01-26
1026 Simultaneous, real-time tracking of many neuromodulatory signals with Multiplexed Optical Recording of Sensors on a micro-Endoscope
Kalugin, P. N.; Soden, P. A.; Massengill, C. I.; Amsalem, O.; Porniece, M.; Guarino, D. C.; Tingley, D.; Zhang, S. X.; Benson, J. C.; Hammell, M. F.; Tong, D. M.; Ausfahl, C. D.; Lacey, T. E.; Courtney, Y.; Hochstetler, A.; Zhang, Y.; Holtzman, M. J.; Wang, H.; Geng, L.; Li, G.; Li, B.; Li, Y.; Lehtinen, M. K.; Andermann, M. L.
10.1101/2025.01.26.634931 — neuroscience — Posted on 2025-01-26
1027 Feature-Driven Whole-Tissue Imaging with Subcellular Resolution
Lin, J.; Marin, Z.; Wang, X.; Borges, H. M.; N'Guetta, P.-E. Y.; Luo, X.; Porter, B. A.; Xue, Y.; Islam, M. T.; Ngo, T.; Aurora, A. B.; Zhao, H.; Conzen, S. D.; Morrison, S. J.; Liang, S.; Zhong, Z.; O'Brien, L. L.; Dean, K. M.
10.1101/2025.01.23.634600 — biophysics — Posted on 2025-01-26
1028 Wearable Photonic Device for Multiple Biomarker Sampling and Detection Without Blood Draws
Lin, Z.-T.; Jana, B.; Korupolu, S.; Kong, Y.; Liu, G.; Dong, Y.; Li, Y.; Zhang, Q.; Shou, W.; Upadhyay, P.; Wu, M. X.
10.1101/2025.01.23.634606 — bioengineering — Posted on 2025-01-26
1032 Nanodomain distribution and function of PIN-FORMED auxin efflux carriers in the plasma membrane of tobacco cells are defined by their interactions with the cell wall
Stelate, A.; Malinska, K.; Tihlarikova, E.; Muller, K.; Vaculikova, R.; Knirsch, M.; Vondrakova, Z.; Vlcak, E.; Retzer, K.; Neubergerova, M.; Pleskot, R.; Harant, K.; Filimonenko, V.; Schwarzerova, K.; Nedela, V.; Petrasek, J.
10.1101/2025.01.23.634346 — plant biology — Posted on 2025-01-26
1033 High-dose DFMO alters protein translation in neuroblastoma
Franson, A. T.; Liu, K.; Vemu, R.; Scadden, E.; Li, Y.; Vu, A.; Hogarty, M. D.
10.1101/2025.01.23.634327 — cancer biology — Posted on 2025-01-26
1035 Unraveling Dengue Serotype 3 Transmission in Brazil: Evidence for Multiple Introductions of the 3III_B.3.2 Lineage
Pereira, J. S.; Slavov, S. N.; Brcko, I. C.; Ribeiro, G.; de Souza, V. C.; Ribeiro, I. S.; de Lima, I. T. T.; Borges, G. A. L.; Furtado, K. C. d. L.; Chagas, S. M. d. S.; da Costa, P. M. S. S. B.; Adelino, T.; Iani, F. C. d. M.; Alcantara, L. C. J.; Hill, V.; Grubaugh, N. D.; Sampaio, S. C.; Sabbaga, M. C.; Giovanetti, M.; Lima, A. R. J.
10.1101/2025.01.23.634513 — bioinformatics — Posted on 2025-01-26
1038 Bioengineered visible polymeric mesh to enhance urogynaecological health
Houshyar, S.; Quigley, A.; Cole, I.; Yin, H.; Zizhou, R. E.; Saha, T.; Pirogova, E.; Yeung, J. M.; Mohsenipour, M.; Mirabedini, A.; Subejano, E.; Shindler, A. E.; Wood, J. L.; Franks, A. E.; Hill-Yardin, E. L.
10.1101/2025.01.23.634411 — bioengineering — Posted on 2025-01-26
1040 Germline-restricted chromosome of songbirds has different centromere compared to regular chromosomes
Ridl, J.; Dedukh, D.; Halenkova, Z.; Schlebusch, S. A.; Benes, V.; Lopez, M. O.; Osiejuk, T. S.; Ruiz-Ruano, F. J.; Suh, A.; Albrecht, T.; Reif, J.; Reifova, R.
10.1101/2025.01.23.634594 — genomics — Posted on 2025-01-26
1043 Stratification along tropical forest succession enhances pollinator diversity via functionally unique canopies
Diniz, U. M.; Böttger, D.; Brehm, G.; Lalama, S. F. V.; Frühholz, K.; Pitz, M.; Windl, J.; Rasmussen, C.; Keller, A.; Leonhardt, S. D.
10.1101/2025.01.23.634515 — ecology — Posted on 2025-01-26
1045 ASK1 overexpression protects from HFD-induced body weight gain via FGF21
Goergen, A.; Challa, T. D.; Borsigova, M.; Villarroel-Vicente, C. V.-V.; Van Krieken, P.; Wueest, S.; Konrad, D.
10.1101/2025.01.23.634369 — physiology — Posted on 2025-01-26
1046 Epidermal tumour-resistant progenitors require SOX2-driven developmental reprogramming to drive tumorigenesis
Centeno, P. P.; Chester, C.; Ford, C. A.; Ridgway, R. A.; Cammareri, P.; Jamieson, T.; Marais, R.; Campbell, A. D.; Sansom, O. J.
10.1101/2025.01.23.634502 — cancer biology — Posted on 2025-01-26
1049 Flavodiiron protein activity outcompetes cyclic electron transport when expressed in angiosperm Nicotiana tabacum
Rizzetto, N.; Traverso, E.; Sabia, A.; Fiorin, F.; Francese, C.; Trainotti, L.; Morosinotto, T.; Alboresi, A.
10.1101/2025.01.23.634494 — plant biology — Posted on 2025-01-26
1050 TGR5-mediated Ca2+ signaling in cholangiocytes
Chen, X.; Al-Shebel, A.; Pebrier, T.; Tordjmann, T.; DELLIS, O.
10.1101/2025.01.23.634480 — physiology — Posted on 2025-01-26
1052 Unmasking Epstein-Barr Role in Gastric Carcinogenesis: A Gene Expression Approach to Virus-Positive Tumors
Santos da Silva, V. C.; Pereira, D.; Avelar, D. d. S.; Silva, J. M. C. d.; Mourao, R. M. d. S.; Silva, R. F. d.; Marcon, D. J.; Magalhaes, L.; Vidal, A. F.; Neotti, T.; Anaissi, A. K. M.; Barra, W. F.; Casseb, S. M.; Ribeiro dos Santos, A. K. C.; Demachki, S.; Ishak, G.; Assumpcao, P. P. d.; Moreira, F.; Burbano, R. M. R.
10.1101/2025.01.23.634441 — cancer biology — Posted on 2025-01-26
1053 Avoidance of fratricide and improved efficacy of CD33-MSLN CAR-iNK cells in treating acute myeloid leukemia
Wang, Y.; Zheng, X.; Wang, Z.; Xiao, Z.; Lin, Y.; Zhang, F.; Liu, Y.; Liu, P.; Weng, Q.; Zhang, L.; Xia, C.; Huang, D.; Liu, L.; Zhu, Y.; Zhang, Q.; Qi, H.; Chen, Y.; Shen, Y.; Zhang, C.; Xu, J.; Zhao, Y.; Wu, J.; Wang, T.; Zhang, M.; Li, M.; Qian, W.; Liang, A.; Du, X.; Yang, W.; Zhu, X.; Hu, F.; Wang, J.
10.1101/2025.01.23.634500 — cancer biology — Posted on 2025-01-26
1059 Fexinidazole and Corallopyronin A target Wolbachia-infected sheath cells present in filarial nematodes
Chappell, L.; Peguero, R.; Connor, W.; Fowler, S.; Cooper, B.; Pfarr, K.; Hoerauf, A.; Lustigman, S.; Sakanari, J.; Sullivan, W.
10.1101/2025.01.23.634442 — pathology — Posted on 2025-01-26
1060 Clinical and Genetic Determinants of Glioblastoma Multiforme Survival: A Retrospective Analysis
Gutierrez-Arroyo, J.; Gallego-Porcar, P.; Carbonell-Martinez, E.; Gonzalez-Bonet, L.; Ibanez, M. V.; Diaz-Ruiz, M.; Caballero-Arzapalo, H.; Soto, A.; Garcia-Oriola, G.; Borras-Moreno, J. M.; Martinez-Cadenas, C.; Marques-Torrejon, M. A.
10.1101/2025.01.23.634459 — cancer biology — Posted on 2025-01-26
1061 DNA origami directed integration of colloidal nanophotonic materials with silicon photonics
Luo, X.; Ranno, L.; Sverko, T.; Lee, J. Y.; Sbalbi, N.; Jones, A.; Chen, C.; Bawendi, M. G.; Hu, J.; Macfarlane, R. J.; Bathe, M.
10.1101/2025.01.23.634416 — bioengineering — Posted on 2025-01-26
1062 BubR1 and Mad2 regulate adult midgut remodeling in Drosophila diapause
Adachi, Y.; Nagai, H.; Fujichika, T.; Takahashi, A.; Miura, M.; Nakajima, Y.
10.1101/2025.01.26.634899 — developmental biology — Posted on 2025-01-26
1064 Sleep in People Experiencing Homelessness Under Different Conditions and Seasons
Rice, A.; Casiraghi, L. P.; Gildee, C.; Almquist, Z. W.; Hagopian, A.; Martin, M. A.; de la Iglesia, H. O.
10.1101/2025.01.23.634551 — physiology — Posted on 2025-01-26
1065 γδ T cells are the prime anti-tumoral T cells in pediatric neuroblastoma
Castenmiller, S. M.; Borst, A. L.; Wardak, L.; Molenaar, J. J.; Papadopoulou, M.; de Krijger, R. R.; van der Steeg, A. F. W.; Vermijlen, D.; de Groot, R.; Wienke, J. M.; Wolkers, M. C.
10.1101/2025.01.23.634553 — cancer biology — Posted on 2025-01-26
1066 Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer
Darracq, A.; Sgarioto, N.; Huot, M.; McInnes, G.; Meant, A.; Langford, A.; Villarreal, O. D.; Marois, F.; Caron, M.; Saint-Onge, P.; Leclerc, S.; Cagnone, G.; Andelfinger, G.; Richard, S.; Sinnett, D.; McGraw, S.; Raynal, N. J.-M.
10.1101/2025.01.23.634518 — cancer biology — Posted on 2025-01-26
1067 Phosphatidylserine (PS)-targeting chimeric Interferon (IFN) fusion proteins for anti-tumor applications
Gadiyar, V.; Davra, V.; Pulica, R.; Frederick, T.; Varsanyi, C.; Aquib, A.; Wang, Z.; Smirnov, S.; Bapat, S.; Calianese, D. C.; Choudhary, A.; Kotenko, S. V.; Birge, R. B.
10.1101/2025.01.24.634764 — cancer biology — Posted on 2025-01-26
1070 Low-frequency ultrasound-mediated blood-brain barrier opening enables non-invasive lipid nanoparticle RNA delivery to glioblastoma
Elbaz, M.; Ad-El, N.; Chulanova, Y.; Brier, D.; Goldsmith, M.; Bismuth, M.; Brosque, A.; Sher, D.; Gutkin, A.; Bar-On, D.; Friedmann-Morvinski, D.; Peer, D.; Ilovitsh, T.
10.1101/2025.01.23.634427 — bioengineering — Posted on 2025-01-26
1071 End-to-end Learning of Safe Stimulation Parameters for Cortical Neuroprosthetic Vision
Kücükoglu, B.; Rueckauer, B.; de Ruyter van Steveninck, J.; van der Grinten, M.; Güclütürk, Y.; Roelfsema, P. R.; Güclü, U.; van Gerven, M.
10.1101/2025.01.23.634543 — bioengineering — Posted on 2025-01-26
1073 Customized feminine hygiene wash containing postbiotics from Lactobacillus spp. to treat Urinary Tract Infections (UTI)
Nair, V. G.; Chellappan, D. R.; Durai, R. D.; Y.B.R.D, R.; Narbhavi, D.; M, A.; N, P.; Nagarajan, S.
10.1101/2025.01.24.634779 — microbiology — Posted on 2025-01-26
1076 Tracing Cellular Senescence in Bone: Time-Dependent Changes in Osteocyte Cytoskeleton Mechanics and Morphology
Tilton, M.; Liao, J.; Kim, C.; Shaygani, H.; Astudillo Potes, M.; Cordova, D.; Kirkland, J. L.; Miller, K.
10.1101/2024.09.28.615585 — biophysics — Posted on 2025-01-26
1078 Elevator mechanism dynamics in a sodium-coupled dicarboxylate transporter
Kinz-Thompson, C. D.; Lopez Redondo, M.; Mulligan, C.; Sauer, D. B.; Marden, J. J.; Song, J.; Tajkhorshid, E.; Hunt, J. F.; Stokes, D. L.; Mindell, J. A.; Wang, D.-N.; Gonzalez, R. L.
10.1101/2022.05.01.490196 — biophysics — Posted on 2025-01-26
1081 Well-resolved phylogeny supports repeated evolution of keel flowers as a synergistic contributor to papilionoid legume diversification
Cai, L.; Cardoso, D.; Tressel, L. G.; Lee, C.; Shrestha, B.; Choi, I.-S.; Lima, H. C.; Queiroz, L. P.; Ruhlman, T. A.; Jansen, R. K.; Wojciechowski, M. F.
10.1101/2024.10.07.617045 — evolutionary biology — Posted on 2025-01-26
1083 Cell autonomous polarization by the planar cell polarity signaling pathway
Weiner, A. T.; Nissen, S. B.; Suyama, K. L.; Cho, B.; Pierre-Louis, G.; Axelrod, J. D.
10.1101/2023.09.26.559449 — developmental biology — Posted on 2025-01-26
1084 Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease
Crnkovic, S.; Thekkekara Puthenparampil, H.; Mulch, S.; Biasin, V.; Radic, N.; Wilhelm, J.; Bartkuhn, M.; Bonyadi Rad, E.; Wawrzen, A.; Matzer, I.; Mitra, A.; Leib, R. D.; Nagy, B. M.; Sahu-Osen, A.; Valzano, F.; Bordag, N.; Evermann, M.; Hoetzenecker, K.; Olschewski, A.; Ljubojevic-Holzer, S.; Wygrecka, M.; Stenmark, K.; Marsh, L. M.; de Jesus Perez, V.; Kwapiszewska, G.
10.1101/2024.05.15.594343 — cell biology — Posted on 2025-01-26
1086 In vivo functional profiling and structural characterisation of the human Glp1r A316T variant
El Eid, L.; Deane-Alder, K.; Rujan, R.-M.; Mariam, Z.; Oqua, A. I.; Manchanda, Y.; Belousoff, M. J.; Bernardino de la Serna, J.; Sloop, K. W.; Rutter, G. A.; Montoya, A.; Withers, D. J.; Millership, S.; Bouzakri, K.; Jones, B.; Reynolds, C. A.; Sexton, P. M.; Wootten, D.; Deganutti, G.; Tomas, A.
10.1101/2024.10.19.619191 — cell biology — Posted on 2025-01-26
1089 A theory of brain-computer interface learning via low-dimensional control
Menendez, J. A.; Hennig, J. A.; Golub, M. D.; Oby, E. R.; Sadtler, P. T.; Batista, A. P.; Chase, S. M.; Yu, B. M.; Latham, P. E.
10.1101/2024.04.18.589952 — neuroscience — Posted on 2025-01-26
1090 Nascent dendrite branches initiated by a localized burst of Spire-dependent actin polymerization.
Hatton, D.; Marquilly, C.; Hanrahan, C.; Ferreira, T. A.; Ou, Y.; Cinq-mars, L.; Silkworth, W.; Bailey, H. M.; Quinlan, M.; van Meyel, D. J.
10.1101/2022.06.16.496481 — neuroscience — Posted on 2025-01-26
1092 Octopamine signals coordinate the spatial pattern of presynaptic machineries within individual Drosophila mushroom body neurons
Wu, H.; Eno, S.; Jinnai, K.; Maekawa, Y.; Saito, K.; Abe, A.; Williams, D. W.; Yamagata, N.; Kondo, S.; Tanimoto, H.
10.1101/2024.12.02.626512 — neuroscience — Posted on 2025-01-26
1093 MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases
Woods, V.; Umansky, T.; Russell, S. M.; McGovern, B. L.; Rosales, R.; Rodriguez, M. L.; van Bakel, H.; Sordillo, E. M.; Simon, V.; Garcia-Sastre, A.; White, K. M.; Brubaker, W. F.; Smith, D. M.; Haders, D.
10.1101/2025.01.13.632836 — pharmacology and toxicology — Posted on 2025-01-26
1094 Low Field Magnetic Resonance Imaging to Detect Acute Kidney Injury
Kishimoto, S.; Kazumasa, H.; Devasahayam, N.; Yamashita, K.; Gadisetti, C.; Yamamoto, K.; Brender, J. R.; Mitchell, J.; Krishna, M. C.; Linehan, W. M.; Crooks, D. R.
10.1101/2025.01.22.634393 — physiology — Posted on 2025-01-25
1095 A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistance
Kozlova, N.; Cruz, K. A.; Doh, H. M.; Ruzette, A. A.; Willis, N. A.; Hong, S. M.; Gonzalez, R. S.; Vyas, M.; Selfors, L. M.; Dreyer, S. B.; Upstill-Goddard, R.; Faia, K. L.; Wenglowsky, S.; Close, J.; Beutel, A. K.; Jutric, Z.; Oliphant, M. U. J.; Thapa, B.; Taylor, M.; Mustonen, V.; Mangalath, P.; Halbrook, C. J.; Grossman, J. E.; Hwang, R. F.; Clohessy, J. G.; Ruskamo, S.; Kursula, P.; Petrova, B.; Kanarek, N.; Cole, P. A.; Chang, D.; Norrelykke, S. F.; Scully, R.; Muranen, T.
10.1101/2025.01.22.634323 — cancer biology — Posted on 2025-01-25
1097 Synthesizing unmodified, supercoiled circular DNA molecules in vitro
Rezaei, S.; Moncada-Restrepo, M.; Leng, S.; Chambers, J. W.; Leng, F.
10.1101/2025.01.24.634800 — biochemistry — Posted on 2025-01-25
1099 Wheat infection by Fusarium graminearum species complex members is facilitated by a transcriptionally conserved non-ribosomal peptide synthetase gene cluster
Tralamazza, S. M.; Nielsen, M. R.; Abraham, L. N.; Atanasoff-Kardjalieff, A. K.; Glauser, G.; Sorensen, J. L.; Studt-Reinhold, L.; Correa, B.; Croll, D.
10.1101/2025.01.24.634825 — microbiology — Posted on 2025-01-25
1100 LubriShieldTM - a unique permanent coating for indwelling urinary catheters that impedes surface-associated uropathogens from forming biofilm
Romero, A. I.; Surkov, S.; Wirsen, P.; Brookes, G.; Bergstrom, L.; Tejbrant, J.; Dhamo, E.; Wilks, S.; Bryant, C.; Andersson, J.
10.1101/2025.01.24.634505 — microbiology — Posted on 2025-01-25
1103 Optimized protocols for commonly-used murine models of heart failure with preserved ejection fraction.
McIntosh, B.; Elbassioni, A.; Raheem, A.; MacDonald, E. A.; Nicklin, S. A.; Koay, Y. C.; Cameron, E. R.; Loughrey, C. M.; O'Sullivan, J. F.
10.1101/2025.01.22.634221 — physiology — Posted on 2025-01-25
1104 Deep learning-driven morphology analysis enables label-free classification of therapeutic agent- naive versus resistant cancer cells
Ramathal, C.; Saini, K.; Lian, Z.; Corona, C.; Pham, T.; Carelli, R.; Boutet, S. C.; Ray, M.; Sethuraman, S.; Prindle, V.; Lattmann, E.; Molvetti, M.-G.; Dzung, A.; Levesque, M.; Barnes, M.; Jovic, A.
10.1101/2025.01.22.634357 — cancer biology — Posted on 2025-01-25
1106 Eg5 Inhibitor SB743921 Causes p53-Dependent Cell Cycle Arrest, Senescence and Death in Tumor Cells
Abramenko, I. E.; Khamidullina, A. I.; Kiryukhina, T. A.; Tvorogova, A. V.; Pavlenko, N. G.; Bruter, A. V.; Tatarskiy, V. V.
10.1101/2025.01.23.634373 — cancer biology — Posted on 2025-01-25
1107 Shared molecular regulation of quiescence in neural and glioma stem cells reveals therapeutic vulnerabilities.
Choudhury, C.; Singleton, M.; Brauer, S.; Friess, D.; Hart, J.; Skarne, N.; Pullela, K.; Mao, L.; Day, B. W.; Harris, L.
10.1101/2025.01.22.634421 — cancer biology — Posted on 2025-01-25
1113 Dual regulatory role of IS91-encoded Orf121 in IS91 transposition
Fauconnier, A.; Da Re, S.; Gaschet, M.; Jove, T.; Ploy, M.-C.; Pasternak, C.
10.1101/2025.01.24.634351 — molecular biology — Posted on 2025-01-25
1114 Glo1 reduction in mice results in age- and sex-dependent metabolic dysfunction
Cely, I.; Blencowe, M.; Shu, L.; Diamante, G.; Ahn, I.; Zhang, G.; LaGuardia, J.; Liu, R.; Saleem, Z.; Wang, S.; Davis, R. C.; Lusis, A. J.; Yang, X.
10.1101/2025.01.24.634754 — molecular biology — Posted on 2025-01-25
1116 Customized feminine hygiene wash containing postbiotics from Lactobacillus spp. to treat Urinary Tract Infections (UTI)
Nair, V. G.; Chellappan, D. R.; Durai, R. D.; Y.B.R.D, R.; Narbhavi, D.; M, A.; N, P.; Nagarajan, S.
10.1101/2025.01.24.634779 — microbiology — Posted on 2025-01-25
1117 Dietary protein source mediates colitis pathogenesis through bacterial modulation of bile acids
Gray, S. M.; Wood, M. C.; Mulkeen, S. C.; Ahmed, S.; Thaker, S. D.; Chen, B.; Sander, W. R.; Bibeva, V.; Zhang, X.; Yang, J.; Herzog, J. W.; Zhang, S.; Dogan, B.; Simpson, K. W.; Sator, R. B.; Montrose, D. C.
10.1101/2025.01.24.634824 — microbiology — Posted on 2025-01-25
1119 Capillary-induced bundling of biopolymer networks via protein condensates
Feigeles, C. A.; Brasovs, A.; Puchalski, A.; Laukat, O.; Kornev, K. G.; Weirich, K. L.
10.1101/2025.01.22.634359 — biophysics — Posted on 2025-01-25
1122 ST-FFPE-mIF: Integrating Spatial Transcriptomics and Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tissues Using Stereo-seq
Zhang, X.; Zhang, M.; Xu, Y.; Song, Y.; Yang, X.; Wu, Y.; Zhao, X.; Ran, D.; Liu, X.; Huang, H.; Lei, W.; Li, H.; Zhang, Y.; Xi, F.; Li, G.; Liu, X.; Xu, L.; Chen, A.; Liao, S.; Zhang, J. j.
10.1101/2025.01.24.634655 — biochemistry — Posted on 2025-01-25
1124 Warming disrupts plant-fungal endophyte symbiosis more strongly in leaves than roots
Edwards, J.; Kazenel, M. R.; Luo, Y.; Lynn, J. S.; McCulley, R. L.; Souza, L.; Young, C.; Rudgers, J. A.; Kivlin, S. N.
10.1101/2025.01.22.634355 — ecology — Posted on 2025-01-25
1127 Attenuated adenosine mediated immune-dampening increases natural killer cell activity in early age-related macular degeneration
Nair, A. P.; Ghosh, S.; Babu, V. S.; Praveen, M.; Xin, Y.; Sahu, G. R.; Vaidya, T. A.; Debnath, J.; Raja, K.; Gadde, S. G. K.; MB, T.; Shetty, N.; Saxena, A.; Shetty, R.; Hose, S.; Deshpande, V.; Chakrabarthy, K.; Handa, J. T.; Qian, J.; Sethu, S.; Sinha, D.; Ghosh, A.
10.1101/2025.01.22.634301 — immunology — Posted on 2025-01-25
1131 Knowledge of effort modulates visual memory biases for body postures
Han, Q.; Gandolfo, M.; Vandommelen, J.; Schoenmacker, S.; Drobnicki, K.; Peelen, M. V.
10.1101/2025.01.24.634717 — neuroscience — Posted on 2025-01-25
1132 Transthyretin Levels and Instability in Alzheimer's Disease: Correlations with AD Biomarkers in a Cohort Study
Giao, T.; Tabuas-Pereira, M.; Baldeiras, I.; Saavedra, J.; Dias, A.; Saraiva, M. J.; Almeida, M. R.; Santana, I.; Cardoso, I.
10.1101/2025.01.24.634710 — neuroscience — Posted on 2025-01-25
1133 Motor cortical circuits are uniquely impacted by different exercise intensities
Harroum, N.; Neva, J.; Pageaux, B.; Joubert, M.; OFarrell, A.; Youssef, L.; Bohbot, L.; Maati, H.
10.1101/2025.01.24.634315 — neuroscience — Posted on 2025-01-25
1139 Synaptic phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein aggregation
Dutta, S.; Hensel, J.; Scott, A.; Mohallem, R.; Rossitto, L.-A. M.; Khan, H. F.; Johnson, T.; Ferreira, C. R.; Marmolejo, J. F.; Chen, X.; Jayant, K.; Aryal, U. K.; Volpicelli-Daley, L.; Rochet, C.
10.1101/2025.01.24.634820 — neuroscience — Posted on 2025-01-25
1140 Balancing Integration and Segregation: StructuralConnectivity as a Driver of Brain Network Dynamics
Palma-Espinosa, J.; Orellana Villouta, S.; Coronel-Oliveros, C.; Maidana, J. P.; Orio, P.
10.1101/2025.01.24.634823 — neuroscience — Posted on 2025-01-25
1141 Operant House: A Versatile Open-Source Platform for Automated Operant Conditioning Testing of Mice in Home Cages
Otsuka, S.; Nakamura, Y.; Ito-Ishida, A.; Suzuki, K.; Ishikawa, A.; Matsuda, K.; Suyama, S.; Contractor, A.; Yuzaki, M.
10.1101/2025.01.24.634815 — neuroscience — Posted on 2025-01-25
1144 Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion
Toshima, N.; Behrad, A.; Behnke, F.; Kaushik, G.; Weiglein, A.; Strauch, M.; Thoener, J.; Kobler, O.; Wang, M. L. M.; Dorr, M.; Schleyer, M.
10.1101/2025.01.23.634646 — neuroscience — Posted on 2025-01-25
1145 Loss of signaling fidelity between astrocyte endfeet and adjacent cerebral arterioles in an amyloid mouse model of Alzheimer's disease
Weiss, B. E.; Gant, J. C.; Lin, R.-L.; Gollihue, J. L.; Kraner, S. D.; Rucker, E. B.; Katsumata, Y.; Jiang, Y.; Nelson, P. T.; Wilcock, D. M.; Sompol, P.; Thibault, O.; norris, c. M.
10.1101/2025.01.24.634584 — neuroscience — Posted on 2025-01-25
1147 Quantification of HER2-low and ultra-low expression in breast cancer specimens by quantitative IHC and artificial intelligence
Aidt, F.; Arbel, E.; Remer, I.; Ben-David, O.; Ben-Dor, A.; Rabkin, D.; Hoff, K.; Salomon, K.; Aviel-Ronen, S.; Nielsen, G.; Mollerup, J.; Jacobsen, L.; Tsalenko, A.
10.1101/2025.01.22.634230 — pathology — Posted on 2025-01-25
1148 Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium
Pellon-Cardenas, O.; Hassan, S.; Fokas, E.; He, P.; Patel, I.; Patel, J.; Plotsker, O.; Wu, A.; Kumar, R.; Akther, M.; Logerfo, A.; Wu, S.; Wagner, D.; Boffelli, D.; Walton, K. D.; Manieri, E.; Tong, K.; Spence, J. R.; Bessman, N. J.; Shivdasani, R. A.; Verzi, M. P.
10.1101/2025.01.22.634326 — cancer biology — Posted on 2025-01-25
1152 StrPhaser constructs tandem repeat alleles from VCF data
Wang, X.; King, J.; Meng, H.; Coble, M. D.; Woerner, A. E.
10.1101/2025.01.22.634325 — bioinformatics — Posted on 2025-01-25
1162 A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndrome
de los Reyes-Ramirez, L.; Bergada-Martinez, A.; Martinez-Torres, S.; Martinez-Gallego, I.; Losada-Ruiz, P.; Arboleya, S.; Gueimonde, M.; Maldonado, R.; Rodriguez-Moreno, A.; Ozaita, A.
10.1101/2025.01.24.634730 — animal behavior and cognition — Posted on 2025-01-25
1164 Single-molecule mitochondrial DNA imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks and selection in different organs in vivo
Chandrasegaram, R.; Hynes-Allen, A. M.; Gao, B.; Dhawanjewar, A.; Frison, M.; Petridi, S.; Chinnery, P. F.; Ma, H.; van den Ameele, J.
10.1101/2025.01.24.634671 — developmental biology — Posted on 2025-01-25
1165 A mosaic gastruloid model highlights the developmental stage-specific restriction of cell competition in mammalian pre-gastrulation
Frenster, J. D.; Babin, S.; Josende Garcia, J. B.; Casani Galdon, P.; Pascual Mas, P.; Robertson, G.; Garcia-Ojalvo, J.; Martinez Arias, A.
10.1101/2025.01.25.634859 — developmental biology — Posted on 2025-01-25
1167 A non-invasive approach to awake mouse fMRI compatible with multi-modal techniques
Laxer, S.; Eed, A.; Bellyou, M.; Zeman, P.; Gilbert, K. M.; Naderi, M.; Menon, R. S.
10.1101/2025.01.23.634586 — neuroscience — Posted on 2025-01-25
1168 Hyperacute Response Proteins (HARPs) synthesized on γ-tubulin-FTO-MARK4 translation microdomains upon exposure to stress, regulate stressresponse in cancer.
Saleme, B.; Tejay, S.; Dembele, P.; Abou Farraj, R.; Zhang, Y.; Liu, Y.; Boukouri, A. E.; Zervopoulos, S. D.; Haromy, A.; Zhao, Y.-Y.; Braun, S.; Saleme, W.; Sun, X.; Fahlman, R.; Glover, M.; Kinnaird, A.; Sutendra, G.; Michelakis, E. D.
10.1101/2025.01.20.633998 — cancer biology — Posted on 2025-01-25
1172 7β-hydroxysteroid dehydratase Hsh3 eliminates the 7-hydroxy group of the bile salt ursodeoxycholate during degradation by Sphingobium sp. strain Chol11 and other Sphingomonadaceae
Richtsmeier, P.; Nedielkov, R.; Haring, M.; Yücel, O.; Elsner, L.; Lülf, R. H.; Wöhlbrand, L.; Rabus, R.; Möller, H.; Philipp, B.; Mueller, F. M.
10.1101/2025.01.23.634595 — microbiology — Posted on 2025-01-25
1176 Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology
Bertaccini, G. A.; Casanellas, I.; Evans, E. L.; Nourse, J. L.; Dickinson, G. D.; Liu, G.; Seal, S.; Ly, A. T.; Holt, J. R.; Wijerathne, T. D.; Yan, S.; Hui, E. E.; Lacroix, J. J.; Panicker, M. M.; Upadhyayula, S.; Parker, I.; Pathak, M. M.
10.1101/2023.12.22.573117 — biophysics — Posted on 2025-01-25
1178 TimeFlies: an snRNA-seq aging clock for the fruit fly head sheds light on sex-biased aging
Tennant, N.; Pavuluri, A.; O'Connor-Giles, K. M.; Singh, G.; Larschan, E.; Singh, R.
10.1101/2024.11.25.625273 — genomics — Posted on 2025-01-25
1186 Evaluating genotyping strategies for a small managed population with simulation
Martin, A. A. A.; Schoenebeck, J.; Clements, D. N.; Lewis, T.; Wiener, P.; Gorjanc, G.
10.1101/2025.01.23.634495 — genomics — Posted on 2025-01-25
1189 Drug-Resistance Biomarkers in Leishmania infantum through Nanopore-Based Detection of Aneuploidy and Gene Copy Number Variations with LeishGenApp
Carrasco Martin, M.; Marti-Carreras, J.; Gomez Ponce, M.; Alcover, M. M.; Roura, X.; Ferrer, L.; Baneth, G.; Bruno, F.; Chicharro, C.; Cordeiro-da-Silva, A.; Cristovao, J.; Di Muccio, T.; Maia, C.; Moreno, J.; Priego, A.; Roca-Gerones, X.; Santarem, N.; Vila Soriano, A.; Vitale, F.; Yasur-Landau, D.; Francino, O.
10.1101/2025.01.23.634476 — genetics — Posted on 2025-01-25
1192 An Evolutionary Novelty in TRPV1 Functional Regulation: Characterization of a Dominant-Negative Isoform Exclusive to Catarrhine Primates
Cancino, S.; Cabezas-Bratesco, D.; Matamala, E.; York, J.; Zavala, K.; Montecinos, C.; Bustamante-Villareal, S.; Maldonado, R.; Riadi, G.; Brauchi, S. E.; Opazo, J. C.
10.1101/2025.01.24.634766 — evolutionary biology — Posted on 2025-01-25
1193 A dual interaction between RSV NS1 and MED25 ACID domain reshapes antiviral responses
Ait-Mouhoub, C.; Dong, J.; Noiray, M.; Fix, J.; Nedvedova, S.; Verger, A.; Eleouet, J.-F.; Descamps, D.; Bajorek, M.; Sizun, C.
10.1101/2025.01.23.634448 — pathology — Posted on 2025-01-25
1194 Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors
Shanmugam, V.; Tokcan, N.; Chafamo, D.; Sullivan, S.; Borji, M.; Martin, H.; Newton, G.; Nadaf, N.; Hanbury, S.; Barrera, I.; Cable, D.; Weir, J.; Ashenberg, O.; Pinkus, G.; Rodig, S.; Uhler, C.; Macosko, E.; Shipp, M.; Louissaint, A.; Chen, F.; Golub, T.
10.1101/2025.01.24.631210 — cancer biology — Posted on 2025-01-25
1197 Unsupervised multi-animal tracking for quantitative ethology
Li, Y.; Li, X.; Zhang, Q.; Zhang, Y.; Fan, J.; Lu, Z.; Li, Z.; Wu, J.; Dai, Q.
10.1101/2025.01.23.634625 — animal behavior and cognition — Posted on 2025-01-25
1198 Evaluation of porcine epidemic diarrhea virus RNA contamination on swine industry transportation vehicles
Parker, T. B.; Meiklejohn, K. A.; Machado, G.; Rahe, M.; Darrow, B. S.; Ferreira, J. B.
10.1101/2025.01.24.634714 — ecology — Posted on 2025-01-25
1199 Assessing predictive accuracy of species abundance models in dynamic systems
Brown, C. J.; Buelow, C. A.; Stuart-Smith, R.; Barrett, N.; Edgar, G.; Oh, E.
10.1101/2025.01.23.634630 — ecology — Posted on 2025-01-25
1200 A rapidly closing window for coral persistence under global warming
Bozec, Y.-M.; Adam, A.; Nava, B. A.; Cresswell, A. K.; Haller-Bull, V.; Iwanaga, T.; Lachs, L.; Matthews, S. A.; McWhorter, J. K.; Anthony, K. R. N.; Condie, S. A.; Halloran, P. R.; Ortiz, J.-C.; Riginos, C.; Mumby, P. J.
10.1101/2025.01.23.634487 — ecology — Posted on 2025-01-25
1202 Temperature and precipitation interactively shape the plant microbiome by regulating the start of the growing season
in 't Zandt, D.; Florianova, A.; urinova, M.; in 't Zandt, M.; Klanderud, K.; Vandvik, V.; Münzbergova, Z.
10.1101/2025.01.23.634453 — ecology — Posted on 2025-01-25
1204 Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses in vitro and in vivo
Verwimp, S.; Wagoner, J.; Arenas, E. G.; De Coninck, L.; Abdelnabi, R.; Hyde, J. L.; Schiffer, J.; White, J. M. M.; Matthijnssens, J.; Neyts, J.; Polyak, S. J.; Delang, L.
10.1101/2025.01.24.633564 — microbiology — Posted on 2025-01-25
1205 Vaccination with mRNA-encoded membrane-bound HIV Envelope trimer induces neutralizing antibodies in animal models
Ramezani-Rad, P.; Cottrell, C. A.; Marina-Zarate, E.; Liguori, A.; Landais, E.; Torres, J. L.; Myers, A.; Lee, J. H.; Baboo, S.; Flynn, C.; McKenney, K.; Salcedo, E.; Zhou, X.; Kalyuzhniy, O.; Georgeson, E.; Phelps, N.; Lu, D.; Eskandarzadeh, S.; Menis, S.; Kubitz, M.; Groschel, B.; Alavi, N.; Jackson, A. M.; Lee, W.-H.; Tran, A. S.; Ben-Akiva, E.; Michaels, K. K.; Diedrich, J. K.; Enemuo, C. A.; Lewis, V.; Pradhan, A.; Kasturi, S. P.; Schiffner, T.; Steichen, J. M.; Carnathan, D. G.; Himansu, S.; Yates, J. R.; Paulson, J. C.; Ozorowski, G.; Irvine, D. J.; Silvestri, G.; Sok, D.; Ward, A. B.;
10.1101/2025.01.24.634423 — immunology — Posted on 2025-01-25
1206 CAR T-cell and oncolytic virus dynamics and determinants of combination therapy success for glioblastoma
Conte, M.; Xella, A.; Woodall, R. T.; Cassady, K. A.; Branciamore, S.; Brown, C.; Rockne, R. C.
10.1101/2025.01.23.634499 — immunology — Posted on 2025-01-25
1207 ANDROGENS PROTECT ILC2S FROM FUNCTIONAL SUPPRESSION DURING INFLUENZA VIRUS INFECTION
Kadel, S.; Miller, R. A. J.; Karlik, A.; Turner, S.; Williams, A. P.; Ainsua-Enrich, E.; Hatipoglu, I.; Bagavant, H.; Alberola-Ila, J.; Garton, J.; Pelikan, R.; Kovats, S.
10.1101/2025.01.23.634583 — immunology — Posted on 2025-01-25
1208 SOX9 plays an essential role in myofibroblast driven hepatic granuloma integrity and parenchymal repair during schistosomiasis-induced liver damage
Su, K.; Jokl, E. J.; Costain, A.; Simpson, K.; Cheeseman, A.; Phythian-Adams, A.; Couper, K.; MacDonald, A.; Piper Hanley, K.
10.1101/2025.01.23.634445 — immunology — Posted on 2025-01-25
1210 Gating of hair cell Ca2+ channels governs the activity of cochlear neurons
Karagulyan, N.; Thirumalai, A.; Michanski, S.; Qi, Y.; Fang, Q.; Wang, H.; Ortner, N. J.; Striessnig, J.; Strenzke, N.; Wichmann, C.; Hua, Y.; Moser, T.
10.1101/2025.01.23.634330 — neuroscience — Posted on 2025-01-25
1212 Synaptome architecture shapes regional dynamics in the mouse brain
Hansen, J. Y.; Luppi, A. I.; Qiu, Z.; Gini, S.; Fulcher, B. D.; Gozzi, A.; Grant, S. G. N.; Misic, B.
10.1101/2025.01.24.634803 — neuroscience — Posted on 2025-01-25
1215 Spatial Heterogeneity and Subtypes of Functional Connectivity Development in Youth
Li, H.; Cui, Z.; Cieslak, M.; Salo, T.; Moore, T. M.; Gur, R. E.; Gur, R. C.; Shinohara, R. T.; Oathes, D. J.; Davatzikos, C.; Satterthwaite, T. D.; Fan, Y.
10.1101/2025.01.24.634828 — neuroscience — Posted on 2025-01-25
1216 A Diverse Genetic Basis for Metabolic Reactions is Revealed Through Pangenome analysis
Ardalani, O.; Phaneuf, P. V.; Krishnan, J.; Li, G.; Burrows, J.; Nielsen, L. K.; Palsson, B. O.
10.1101/2025.01.23.634541 — systems biology — Posted on 2025-01-25
1217 Transcriptional Dynamics and Chromatin Accessibility in the Regulation of Shade-Responsive Genes in Arabidopsis
Paulisic, S.; Boccaccini, A.; Dreos, R.; Ambrosini, G.; Guex, N.; Benstei, R. M.; Schmid, M.; Fankhauser, C.
10.1101/2025.01.23.634457 — plant biology — Posted on 2025-01-25
1219 Worldwide patterns in mythology echo the human expansion out of Africa
Delbrassine, H.; Mezzavilla, M.; Vallini, L.; Berezkin, Y.; Bortolini, E.; Tehrani, J.; Pagani, L.
10.1101/2025.01.24.634692 — evolutionary biology — Posted on 2025-01-25
1220 Mettl15-Mettl17 modulates the transition from early to late pre-mitoribosome
Zgadzay, Y.; Mirabello, C.; Wanes, G.; Panek, T.; Chauhan, P.; Nystedt, B.; Zikova, A.; Gahura, O.; Amunts, A.
10.1101/2024.12.18.629302 — molecular biology — Posted on 2025-01-24
1221 JNK regulates GABAAR expression at the cell surface via the receptor clustering protein GIT1 (ArfGAP1)
Varidaki, A.; Deshpande, P.; Nagaeva, E.; Sino, V.; Schäfer, A.; Sourander, C.; Lagerholm, C.; James, P.; Korpi, E. R.; Coffey, E.
10.1101/2025.01.22.634236 — neuroscience — Posted on 2025-01-25
1223 Enhancing Gene Set Overrepresentation Analysis with Large Language Models
Zhu, J.; Wang, R. Y.; Wang, X.; Azevedo, R.; Moreno, A.; Kuhn, J. A.; Khan, Z.
10.1101/2024.11.11.621189 — bioinformatics — Posted on 2025-01-24
1225 Toward De Novo Protein Design from Natural Language
Dai, F.; Fan, Y.; Su, J.; Wang, C.; Han, C.; Zhou, X.; Liu, J.; Qian, H.; Wang, S.; Zeng, A.; Wang, Y.; Yuan, F.
10.1101/2024.08.01.606258 — bioengineering — Posted on 2025-01-24
1228 Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes
Ewald, J. D.; Titterton, K. L.; Bäuerle, A.; Beatson, A.; Boiko, D. A.; Cabrera, A. A.; Cheah, J.; Cimini, B. A.; Gorissen, B.; Jones, T.; Karczewski, K.; Rouquie, D.; Seal, S.; Weisbart, E.; White, B.; Carpenter, A. E.; Singh, S.
10.1101/2025.01.22.634152 — pharmacology and toxicology — Posted on 2025-01-24
1232 Seasonal Enhancement of the Viral Shunt Catalyzes a Subsurface Oxygen Maximum in the Sargasso Sea
Gilbert, N. E.; Muratore, D.; Shopen Gochev, C.; LeCleir, G. R.; Cagle, S. M.; Pound, H. L.; Sun, C. L.; Carillo, A.; Ndlovu, K. S.; Maidanik, I.; Coenen, A. R.; Chittick, L.; DeBruyn, J. M.; Buchan, A.; Lindell, D.; Sullivan, M. B.; Weitz, J. S.; Wilhelm, S. W.
10.1101/2025.01.23.634377 — ecology — Posted on 2025-01-24
1233 A strong relationship between environmental DNA metabarcoding and rank-based abundance of fish
Littlefair, J. E.; Hayhurst, L. D.; Yates, M. C.; Rennie, M. D.; Cristescu, M. E.
10.1101/2025.01.22.634322 — ecology — Posted on 2025-01-24
1236 Molecular Insights into Fungal Innate Immunity Using the Neurospora crassa - Pseudomonas syringae Model
Stark, F. G.; Torii-Karch, M.; Yuvaraj, S.; Bonometti, L.; Gladieux, P.; Glass, L.; Krasileva, K.
10.1101/2025.01.22.633611 — immunology — Posted on 2025-01-24
1237 Detection of low pre-existing humoral immunity against influenza virus H5N1 clade 2.3.4.4b in unexposed individuals
Daniel, K.; Ullrich, L.; Ruchnewitz, D.; Meijers, M.; Halwe, N. J.; Wild, U.; Eberhardt, J.; Stumpf, R.; Schlotz, M.; Wunsch, M.; Girao Lessa, L.; Dietrich, C.; Pinger, A.; Schumacher, A.-L.; Germer, M.; Rohde, M.; Kukat, C.; Gieselmann, L.; Gruell, H.; Hoffmann, D.; Beer, M.; Erren, T.; Lässig, M.; Kreer, C.; Klein, F.
10.1101/2025.01.22.634277 — immunology — Posted on 2025-01-24
1239 Lipid nanoparticle delivery of siRNA to dorsal root ganglion neurons to treat pain
Han, X.; Petrova, V.; Song, Y.; Cheng, Y.-T.; Jiang, X.; Zhou, H.; Hu, C.; Chen, D. S.; Yong, H. J.; Kim, H. W.; Zhang, B.; Barkai, O.; Jain, A.; Renthal, W.; Lirk, P.; Woolf, C. J.; Shi, J.
10.1101/2025.01.23.633455 — neuroscience — Posted on 2025-01-24
1240 17β-Estradiol Counteracts Pathological Microtubule Remodeling To Enhance Cardiac Function
Moon, R.; Vogel, N.; Mendelson, J. B.; Hartweck, L.; Carney, J.; Kim, M.; Gardner, M. K.; Prisco, S.; Prins, K.
10.1101/2025.01.22.634271 — physiology — Posted on 2025-01-24
1241 The E2F4 transcriptional repressor is a key mechanistic regulator of colon cancer resistance to irinotecan (CPT-11).
Matsubara, J.; Li, Y. F.; Koul, S.; Mukohyama, J.; Valencia Salazar, L. E.; Isobe, T.; Qian, D.; Clarke, M. F.; Sahoo, D.; Altman, R. B.; Dalerba, P.
10.1101/2025.01.22.633435 — cancer biology — Posted on 2025-01-24
1242 Oxidative Phosphorylation (OXPHOS) Promotes the Formation and Growth of Melanoma Lung and Brain Metastases
Guerrieri, R. A.; Fischer, G. M.; Kircher, D. A.; Joon, A. Y.; Cortez, J. R.; Grossman, A. H.; Hudgens, C. W.; Ledesma, D. A.; Lazcano, R.; Onana, C. Y.; Knighton, B. G.; Kumar, S.; Hu, Q.; Yennu-Nanda, V. G.; McQuade, J. L.; Deng, W.; Haydu, L. E.; Gershenwald, J. E.; Lazar, A. J.; Tetzlaff, M. T.; Holmen, S. L.; Davies, M. A.
10.1101/2025.01.23.633049 — cancer biology — Posted on 2025-01-24
1243 Interplay between high-energy quenching and state transitions in Chlamydomonas reinhardtii: a single-cell approach
Lahlou, A.; Orlando, M.; Bujaldon, S.; Gaultier, W.; Israelievitch, E.; Hanappe, P.; Le Saux, T.; Jullien, L.; Colliaux, D.; Bailleul, B.
10.1101/2025.01.23.633867 — biophysics — Posted on 2025-01-24
1245 The fractionation dependence of tumor control in proton therapy for early-stage non-small cell lung cancer
Jeong, J.; Taasti, V. T.; Jackson, A.; Gouw, Z. A. R.; Simone, C. B.; Lambin, P.; Deasy, J. O.
10.1101/2025.01.23.632803 — biophysics — Posted on 2025-01-24
1251 Anopheles stephensi larval habitat superproductivity and its relevance for larval source management in Africa
Yared, S.; Dengela, D.; Mumba, P.; Chibsa, S.; Zohdy, S.; Irish, S. R.; Yoshimizu, M.; Balkew, M.; Akuno, A.; Perkins, T. A.; Vazquez-Prokopec, G.
10.1101/2025.01.23.633752 — ecology — Posted on 2025-01-24
1254 Biosynthetic plasticity enables CD8+ T cell functional resilience under nutrient stress
Scaglione, M.; Knight, M.; Trihemasava, K.; Rome, K.; Archambault, A.-S.; Oh, J.; Tanaka, E.; Hall, E.; Le, V.; Lines, C. L.; Goldspiel, B.; Fazelinia, H.; Queriault, C.; Turner, L.; Parnaik, T.; Xu, J.; Spruce, L. A.; Bartman, C.; Mesaros, C.; Klein Geltink, R. I.; Conn, C. S.; Bailis, W.
10.1101/2025.01.22.632829 — immunology — Posted on 2025-01-24
1256 Enterovirus D68 2A protease causes nuclear pore complex dysfunction and motor neuron toxicity
Zinn, K. M.; McLaren, M. W.; Imai, M. T.; Jayaram, M. M.; Rothestein, J. D.; Elrick, M. J.
10.1101/2025.01.23.632178 — neuroscience — Posted on 2025-01-24
1257 Psychedelic-mediated Reversal of General Anesthesia and Restoration of Brain Dynamics in Rat
Huels, E. R.; Kolbman, N.; Fields, C. W.; Nelson, A. G.; Jackson, H.; Liu, T.; Mashour, G. A.; Pal, D.
10.1101/2025.01.22.632279 — neuroscience — Posted on 2025-01-24
1258 Smooth Muscle Cells and Fibroblasts in the Proximal Thoracic Aorta Exhibit Minor Differences Between Embryonic Origins in Angiotensin II-driven Transcriptional Alterations
Ito, S.; Graf, D. B.; Katsumata, Y.; Moorleghen, J. J.; Zhang, C.; Li, Y.; LeMaire, S. A.; Shen, Y. H.; Lu, H. S.; Daugherty, A.; Sawada, H.
10.1101/2025.01.23.610985 — pathology — Posted on 2025-01-24
1259 Bi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal disease
Ren, H.; Elliott, N.; Lye, B.; Shohan, M.; Cross, J.; Field, L.; Ponnusamy, K.; Rice, S.; Jackson, T.; Leontari, I.; Ouazzani, N.; Thomas, R.; Inglott, S.; Bartram, J.; Smith, O.; Bond, J.; Roberts, I. A.; Halsey, C.; Bashford-Rogers, R. J. M.; Milne, T.; Roy, A.; Karadimitris, A.
10.1101/2025.01.22.633541 — cancer biology — Posted on 2025-01-24
1260 3D dynamic multiscale force and shape analysis of in-vivo elastic stress sensors
Jurado Jimenez, A.; Isensee, J.; Hofemeier, A.; Krueger, L. J.; Wittkowski, R.; Golestanian, R.; Bittihn, P.; Betz, T.
10.1101/2025.01.22.633835 — biophysics — Posted on 2025-01-24
1261 Intraluminal pressure triggers a rapid and persistent reinforcement of endothelial barriers
Bancaud, A.; nakajima, T.; Suehiro, J.-I.; Alric, B.; Morfoisse, F.; Cacheux, J.; Matsunaga, Y. T.
10.1101/2025.01.22.634268 — biophysics — Posted on 2025-01-24
1262 Single-molecule tweezers decoding hidden dimerization patterns of membrane proteins within lipid bilayers
Sadongo, V. W.; Kim, E.; Kim, S.; Wijesinghe, W. C. B.; Lee, T. S.; Choi, J.-M.; Min, D.
10.1101/2025.01.22.634249 — biophysics — Posted on 2025-01-24
1263 AC electro-osmosis in bacterial biofilms: a cautionary tale for electrophysiology experiments
Carneiro da Cunha Martorelli, V.; Akabuogu, E.; Tank, R.; Krasovec, R.; Roberts, I.; Waigh, T. A.
10.1101/2025.01.22.634266 — biophysics — Posted on 2025-01-24
1264 Data Fusion for Integrative Species Identification Using Deep Learning
Koesters, L. M.; Karbstein, K.; Hofmann, M.; Hodac, L.; Maeder, P.; Waeldchen, J.
10.1101/2025.01.22.634270 — bioinformatics — Posted on 2025-01-24
1266 A cyanobacterial screening platform for Rubisco mutant variants
Hoffmann, U. A.; Schuppe, A. Z.; Knave, A.; Sporre, E.; Brismar, H.; Englund, E.; Syren, P.-O.; Hudson, E. P.
10.1101/2025.01.22.633911 — bioengineering — Posted on 2025-01-24
1269 Extensive genome evolution distinguishes maize within a stable tribe of grasses
Stitzer, M. C.; Seetharam, A. S.; Scheben, A.; Hsu, S.-K.; Schulz, A. J.; AuBuchon-Elder, T.; El-Walid, M.; Ferebee, T. H.; Hale, C. O.; La, T.; Liu, Z.-Y.; McMorrow, S. J.; Minx, P.; Phillips, A.; Syring, M.; Wrightsman, T.; Zhai, J.; Pasquet, R.; McAllister, C.; Malcomber, S.; Traiperm, P.; Layton, D.; Zhong, J.; Costich, D. E.; Dawe, R. K.; Fengler, K.; Harris, C.; Irelan, Z.; Llaca, V.; Parakkal, P.; Zastrow-Hayes, G.; Woodhouse, M. R.; Cannon, E. K.; Portwood, J.; Andorf, C. M.; Albert, P. S.; Birchler, J. A.; Siepel, A.; Ross-Ibarra, J.; Romay, M. C.; Kellogg, E.; Buckler, E. S.; Hufford
10.1101/2025.01.22.633974 — evolutionary biology — Posted on 2025-01-24
1270 Global loss of responsiveness in key regulator metabolites and elevated enzyme proteins as metabolic dysregulation in skeletal muscle and liver of obese mice during starvation
Li, D.; Morita, K.; Kokaji, T.; Hatano, A.; Hirayama, A.; Soga, T.; Suzuki, Y.; Matsumoto, M.; Tsuchiya, T.; Ozaki, H.; Ohno, S.; Inoue, H.; Inaba, Y.; Sugimoto, H.; Pan, Y.; Kuroda, S.
10.1101/2025.01.22.634184 — systems biology — Posted on 2025-01-24
1271 Regulation of B cell tolerance and autoimmunity by miR-130b
Herrero-Fernandez, B.; Gonzalez-Molina, M. d. P.; Gamez-Reche, L.; Prieto-Munoz, A. M.; Sanz, J.; Gonzalo, T.; Moreno, A.; Nemazee, D.; Xiao, C.; Manas, L.; Gonzalez-Martin, A.
10.1101/2025.01.22.634242 — immunology — Posted on 2025-01-24
1275 Integrative spatial transcriptomic analysis pinpoints the role of TaMCO3 encoding ferroxidase in wheat root tip iron mobilization
Joon, R.; Singh, G.; Tyagi, D.; Meena, V.; Shukla, V.; Agrwal, K.; Banoo, H.; Satbhai, S.; Singh, J.; Long, T.; Ramireddy, E.; PANDEY, A. K.
10.1101/2025.01.22.634289 — plant biology — Posted on 2025-01-24
1276 Winter rye root growth and plasticity in response to nitrogen and phosphorus omission under field conditions.
Nyameasem, J. K.; Seidel, S. J.; Hadir, S.; Lopez, G. M.; Bauke, S. L.; Hernandez-Ochoa, I. M.
10.1101/2025.01.22.634240 — physiology — Posted on 2025-01-24
1278 Extrachromosomal circular DNA promotes inflammation and hepatocellular carcinoma development
Chan, L. K.; Shan, J.; Rodriguez-Fos, E.; Healy, M.; Leary, P.; Parrotta, R.; Desboeufs, N.; Semere, G.; Wittstruck, N.; Henssen, A.; Weber, A.
10.1101/2025.01.22.634016 — cancer biology — Posted on 2025-01-24
1279 Spatial profiling identifies regionally distinct microenvironments and targetable immunosuppressive mechanisms in pediatric osteosarcoma pulmonary metastases.
Eigenbrood, J.; Wong, N.; Mallory, P.; Pereira, J.; Morris, D. W.; Beck, J. A.; Cronk, J. C.; Sayers, C. M.; Mendez, M.; Kaiser, L.; Galindo, J.; Singh, J.; Cardamone, A.; Pore, M.; Kelly, M. C.; LeBlanc, A. K.; Cotter, J.; Kaplan, R. N.; McEachron, T. A.
10.1101/2025.01.22.631350 — cancer biology — Posted on 2025-01-24
1280 Evolution of chronic lymphocytic leukemia after allogeneic stem cell transplant
Garber, H. R.; Wang, D.; Kerros, C.; Beird, H. C.; Mao, X.; Howard, N. G.; Zhang, J.; Roszik, J.; Miller, J. P.; Leonard, P.; Cao, Y.; Zhao, L.; Song, X.; Seth, S.; Lin, P.; Sun, H.; St John, L. S.; Lu, S.; Wierda, W.; Khouri, I. F.; Clise-Dwyer, K.; Lm, J. S.; Alatrash, G.; Futreal, P. A.; Liang, S.; Koppikar, P.; Gu, S.; Molldrem, J. J.
10.1101/2025.01.22.634212 — cancer biology — Posted on 2025-01-24
1281 A pan-cancer atlas of T cell targets
Li, G.; Guzman-Bringas, O. U.; Sharma, A.; Harpaz, Z.; Tardio, E.; Natarajan, A.; Liu, X.; Taylor, D.; Yamin, R.; Dellacherie, M.; Krogsgaard, M.; Cruz, C. R.; Yarmarkovich, M.
10.1101/2025.01.22.634237 — cancer biology — Posted on 2025-01-24
1282 Adaptive Plasticity Tumor Cells Modulate MAPK-Targeting Therapy Response in Colorectal Cancer
Villarreal, O. E.; Xu, Y.; Tran, H.; Machado, A.; Prescod, D.; Anderson, A.; Minelli, R.; Peoples, M.; Lee, H. M.; Wong, C. W.; Fowlkes, N.; Kanikarla, P.; Sorokin, A.; Alshenaifi, J. Y.; Coker, O.; Lin, K.; Bristow, C.; Viale, A.; Shen, J. P.; Parseghian, C.; Marszalek, J. R.; Corcoran, R.; Kopetz, S.
10.1101/2025.01.22.634215 — cancer biology — Posted on 2025-01-24
1283 Physical confinement regulates transition in nematode motility
Dey, S.; Sreepadmanabh, M.; Kundu, S.; Arun, A. B.; Koushika, S. P.; Thutupalli, S.; Hewitt, D.; Bhattacharjee, T.
10.1101/2025.01.22.633777 — biophysics — Posted on 2025-01-24
1284 Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies
Silva, A.; Duarte-Silva, S.; Martins, P. M.; Rodrigues, B.; Serrenho, D.; Vilasboas-Campos, D.; Teixeira-Castro, A.; Vieyto-Nunez, J.; Mieres-Perez, J.; Figueiredo, F.; Fraga, J.; Noble, J.; Lantz, C.; Sepanj, N.; Monteiro-Fernandes, D.; Guerreiro, S.; Neves-Carvalho, A.; Pereira-Sousa, J.; Klärner, F.-G.; Schrader, T.; Loo, J. A.; Pastore, A.; Sanchez-Garcia, E.; Bitan, G.; Carvalho, A. L.; Maciel, P.; Macedo-Ribeiro, S.
10.1101/2025.01.22.633970 — biophysics — Posted on 2025-01-24
1286 Chemistry-based vectors map the chemical space of natural biomes from untargeted mass spectrometry data
Peets, P.; Litos, A.; Duehrkop, K.; Garza, D. R.; van der Hooft, J. J. J.; Boecker, S.; Dutilh, B. E.
10.1101/2025.01.22.634253 — bioinformatics — Posted on 2025-01-24
1287 mzQuality: A tool for quality monitoring and reporting of targeted mass spectrometry measurements
van der Peet, M.; Maas, P.; Wegrzyn, A. B.; Lamont, L.; Fleming, R. M.; Harms, A. C.; Hankemeier, T.; Kindt, A.
10.1101/2025.01.22.633547 — bioinformatics — Posted on 2025-01-24
1288 Region-specific mean field models enhance simulations of local and global brain dynamics
Lorenzi, R. M.; Palesi, F.; Casellato, C.; Gandini Wheeler-Kingshott, C. A. M.; D'Angelo, E. U.
10.1101/2025.01.22.634225 — bioengineering — Posted on 2025-01-24
1290 Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes
Janeva, A.; Penfold, C. A.; Llorente-Armijo, S.; Li, H.; Zikmund, T.; Stock, M.; Jullien, J.; Straub, T.; Forne, I.; Imhof, A.; Vaquerizas, J. M.; Gurdon, J. B.; Hoermanseder, E. B.
10.1101/2025.01.22.634227 — genomics — Posted on 2025-01-24
1292 A high-quality reference genome for the Ural Owl (Strix uralensis) enables investigations of cell cultures as a genomic resource for endangered species
Chrysostomakis, I.; Mozer, A.; Bruno Di-Nizo, C.; Fischer, D.; Sargheini, N.; von der Mark, L.; Huettel, B.; Astrin, J. J.; Toepfer, T.; Boehne, A.
10.1101/2025.01.22.633903 — genomics — Posted on 2025-01-24
1293 The Type IV Secretion System of Patescibacteria is homologous to the bacterial monoderm conjugation machinery
Quinonero-Coronel, M. d. M.; Cabello-Yeves, P. J.; Haro-Moreno, J. M.; Rodriguez-Valera, F.; Garcillan-Barcia, M. P.
10.1101/2025.01.22.634366 — genomics — Posted on 2025-01-24
1294 Exploring the role of transposable elements to sex gap in longevity in Drosophila species
Merenciano, M.; Janillon, S.; Mermet-Bouvier, C.; Burlet, N.; Rodriguez-Rada, V.; Ronget, V.; Gibert, P.; Gaillard, J.-M.; Lemaitre, J.-F.; Marais, G. A.; Boulesteix, M.; Fablet, M.; Vieira, C.
10.1101/2025.01.22.634250 — genomics — Posted on 2025-01-24
1299 Needle in a haystack: A droplet digital polymerase chain reaction assay to detect rare helminth parasites infecting natural host populations
Fouilloux, C. A.; Neeno-Eckwall, E.; Srinivas, I.; Compton, J. S.; Sampson, J.; Weber, J. N.; Wolf, C.; Hund, A. K.; Berini, J.; Alexander, H.; Choi, E.; Bolnick, D. I.; Hite, J. L.
10.1101/2025.01.23.634533 — molecular biology — Posted on 2025-01-24
1301 Metastatic cell plasticity is maintained by SOX9 function during mitosis in breast cancer
Zippo, A.; Beyes, S.; Michelatti, D.; Negri, M. L.; Morelli, L.; Fagnocchi, L.; Frigoli, E.
10.1101/2025.01.24.633933 — molecular biology — Posted on 2025-01-24
1302 Structures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism of ubiquitin-independent proteasomal degradation
Maestro-Lopez, M.; Cheung Cheng, T.; Muntaner, J.; Menendez, M.; Alonso, M.; Schweitzer, A.; Cuellar, J.; Valpuesta, J. M.; Sakata, E.
10.1101/2025.01.22.633148 — molecular biology — Posted on 2025-01-24
1303 Path of differentiation defines human macrophage identity
Frenis, K.; Badalamenti, B.; Mamigonian, O.; Weng, C.; Wang, D.; Fierstein, S.; Cote, P.; Khong, H.; Li, H.; Lummertz da Rocha, E.; Sankaran, V.; Rowe, R. G.
10.1101/2025.01.24.634694 — molecular biology — Posted on 2025-01-24
1305 The Single Cell Landscape of the Human Vein After Arteriovenous Fistula Creation and Implications for Maturation Failure
Martinez, L.; Stoyell-Conti, F. F.; Tabbara, M.; Rojas, M. G.; Pereira-Simon, S.; Santos Falcon, N.; Hernandez Lopez, R.; Galtes, D.; Kosanovic, C.; Griswold, A. J.; Yang, X.; Shiu, Y.-T.; Lee, T.; Duque, J. C.; Ladino, M. A.; Salman, L. H.; Long, X.; Vazquez-Padron, R. I.
10.1101/2025.01.23.634529 — molecular biology — Posted on 2025-01-24
1308 CD8+ T cells mediate vaccination-induced lymphatic containment of latent Mycobacterium tuberculosis infection following immunosuppression, while B cells are dispensable
Miranda-Hernandez, S.; Kumar, M.; Henderson, A.; Graham, E.; Tan, X.; Taylor, J.; Meehan, M.; Ceja, Z.; del Pozo-Ramos, L.; Pan, Y.; Tsui, E.; Donovan, M. L.; Renteria, M. E.; Flores-Valdez, M. A.; Blumenthal, A.; Nguyen, Q.; Subbian, S.; Field, M. A.; Kupz, A.
10.1101/2025.01.23.634479 — immunology — Posted on 2025-01-24
1311 Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site-Specific Integration of CFTR and Mutation-Agnostic Disease Rescue
Foley, R. A.; Ayoub, P. G.; Sinha, V.; Juett, C.; Sanoyca, A.; Duggan, E. C.; Lathrop, L. E.; Bhatt, P.; Coote, K.; Illek, B.; Gomperts, B. N.; Kohn, D. B.; Jonas, S. J.
10.1101/2025.01.22.633938 — bioengineering — Posted on 2025-01-24
1312 Identification of a novel false-positive mechanism in RapidFire mass spectrometry and application in drug discovery
Pearson, L.-A.; Lin, D.; Ahmad, S. A.; O'Neill, S.; Post, J. M.; Robinson, C.; Scott, D. E.; Gilbert, I. H.
10.1101/2025.01.24.634670 — biochemistry — Posted on 2025-01-24
1313 Exogenous Amyloid Sequences: Their Role in Amyloid-Beta Heterotypic Aggregation
Seira Curto, J.; Fernandez Gallegos, M. R.; Villegas Hernandez, S.; Sanchez de Groot, N.
10.1101/2025.01.24.634659 — biochemistry — Posted on 2025-01-24
1316 Dual Probe Ligation In Situ Hybridization with Rolling-Circle Amplification for High-Plex Spatial Transcriptomics
Maguire, S.; Credle, J.; Bertelson, E.; Lee, S.; Cha, B.; Xie, D.; Kirk, G.; Ray, D.; George, L.; Suru, A.; Maalouf, A.; Ikenaga, C.; Lloyd, T.; Llosa, N.; Larman, H. B.
10.1101/2025.01.22.634417 — molecular biology — Posted on 2025-01-24
1320 Physiologically-relevant light exposure and light behaviour in Switzerland and Malaysia
Biller, A.; Zauner, J.; Cajochen, C.; Gerle, M. A.; Kalavally, V.; Mohammed, A.; Rottlaender, L.; Seah, M.-Y.; Stefani, O.; Spitschan, M.
10.1101/2025.01.07.631760 — neuroscience — Posted on 2025-01-24
1323 Adaptation shapes the representational geometry in mouse V1 to efficiently encode the environment
Dipoppa, M.; Nogueira, R.; Bugeon, S.; Friedman, Y.; Reddy, C. B.; Harris, K. D.; Ringach, D. L.; Miller, K. D.; Carandini, M.; Fusi, S.
10.1101/2024.12.11.628035 — neuroscience — Posted on 2025-01-24
1325 Mapping cell-cell fusion at single-cell resolution
Gardner, A. L.; Zheng, L.; Howland, K. K.; Saunders, A.; Ramirez, A.; Parker, P.; Iloegbunam, C.; Morgan, D.; Jost, T. A.; Brock, A.
10.1101/2024.12.11.627873 — systems biology — Posted on 2025-01-24
1329 Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF: Evidence for Synergistic Benefit with GLP-1/Glucagon Agonism
Doiron, J.; Elbatreek, M.; Xia, H.; Yu, X.; Gehred, N.; Gromova, T. M.; Chen, J.; Driver, I.; Muraoka, N.; Jensen, M.; Shambhu, S.; Tang, W. H. W.; LaPenna, K.; Sharp, T.; Goodchild, T.; Xian, M.; Xu, S.; Quiriarte, H.; Allerton, T.; Zagouras, A.; Wilcox, J.; Shah, S.; Pfeilschifter, J.; Beck, K.-F.; Vondriska, T.; Li, Z.; Lefer, D.
10.1101/2024.09.16.613349 — pharmacology and toxicology — Posted on 2025-01-24
1331 Metastatic organotropism in small cell lung cancer
Krishnamurthy, M.; Dhall, A.; Sahoo, S.; Schultz, C. W.; Baird, M. A.; Desai, P.; Odell, J.; Takahashi, N.; Nirula, M.; Zhuang, S.; Huang, Y.; Schroeder, B.; Zhang, Y.; Thomas, M. S.; Redon, C.; Robinson, C.; Thang, L.; Ileva, L.; Patel, N. L.; Kalen, J. D.; Varlet, A.-A.; Zuela-Sopilniak, N.; Jha, A.; Wangsa, D.; Butcher, D.; Morgan, T.; Afzal, A. N.; Chari, R.; Baktiar, K.; Kumar, S.; Pongor, L.; Difilippantonio, S.; Aladjem, M. I.; Pommier, Y.; Jolly, M. K.; Lammerding, J.; Sharma, A. K.; Thomas, A.
10.1101/2024.10.07.617066 — cancer biology — Posted on 2025-01-24
1332 Cytosolic transport of citrate protects nutrient-austere pancreatic cancer from ferroptosis
Kneebone, A.; Lindaur, K.; Abbas, A.; Cassel, J.; Graff, S.; Abood, G.; Ding, X.; Small, W.; Tatsuoka, C.; Sidoli, S.; Salvino, J. M.; Vaziri-Gohar, A.
10.1101/2025.01.15.633097 — cancer biology — Posted on 2025-01-24
1333 Artificial Intelligence Apps for Medical Image Analysis using pyCERR and Cancer Genomics Cloud
Apte, A.; LoCastro, E.; Iyer, A.; Elguindi, S.; Jiang, J.; Oh, J. H.; Veeraraghavan, H.; Dave, A.; Deasy, J. O.
10.1101/2025.01.19.633756 — bioinformatics — Posted on 2025-01-24
1335 Macromolecular Diamidobenzimidazole Conjugates Activate STING
Arora, K.; Sheehy, T. L.; Schulman, J. A.; Kimmel, B. R.; McAtee, C.; Bharti, V.; Weaver, A.; Wilson, J. T.
10.1101/2025.01.21.634206 — bioengineering — Posted on 2025-01-24
1342 A single dorsal vagal complex circuit mediates the aversive and anorectic responses to GLP1R agonists
Yacawych, W. T.; Wang, Y.; Zhou, G.; Hassan, S.; Kernodle, S.; Sass, F.; Devaus, M.; Wu, I.; Rupp, A.; Tomlinson, A. J.; Lin, Z.; Secher, A.; Raun, K.; Pers, T.; Seeley, R. J.; Myers, M. G.; Qui, W.
10.1101/2025.01.21.634167 — neuroscience — Posted on 2025-01-24
1345 AlphaCross-XL: a seamless tool for automated and proteome-scale map-ping of crosslinked peptides onto three-dimensional protein structures
Shenoy, S. V.; Biswas, D.; Mandal, K.; Zalevsky, A.; Kishishita, A.; Verma, A.; Upadhay, I.; He, Y.; Sali, A.; Viner, R.; Srivastava, S.; Wiita, A. P.
10.1101/2025.01.21.633663 — bioinformatics — Posted on 2025-01-24
1346 NEAR: Neural Embeddings for Amino acid Relationships
Olson, D. R.; Colligan, T.; Demekas, D.; Roddy, J. W.; Youens-Clark, K.; Wheeler, T.
10.1101/2024.01.25.577287 — bioinformatics — Posted on 2025-01-24
1347 De novo Autogenic Engineered Living Functional Materials
Hammad, H. M.; Swarnadeep, S.; Crater, E. R.; Moore, R. B.; Deshmukh, S.; Manjula-Basavanna, A.; Duraj-Thatte, A. M.
10.1101/2025.01.21.634218 — bioengineering — Posted on 2025-01-24
1349 The paradoxical impact of drought on West Nile virus risk: insights from long-term ecological data
Sambado, S.; Sipin, T. J.; Rennie, Z.; Larsen, A.; Cunningham, J.; Quandt, A.; Sousa, D.; MacDonald, A. J.
10.1101/2025.01.21.634155 — ecology — Posted on 2025-01-24
1351 Distinct Colitis-Associated Macrophages Drive NOD2-DependentBacterial Sensing and Gut Homeostasis
Katkar, G.; Anandachar, M. S.; Ibeawuchi, S.-R.; Espinoza, C.; Coates, J.; Malhotra, Y.; Mullick, M.; Castillo, V.; Vo, D. T.; Sahoo, D.; Sinha, S.; Ghosh, P.
10.1101/2025.01.21.634180 — immunology — Posted on 2025-01-24
1352 High-speed mapping of whole-mouse peripheral nerves at subcellular resolution
Shi, M.-Y.; Yao, Y.; Wang, M.; Yang, Q.; Ding, L.; Li, R.; Li, Y.; Huang, H.; Yang, C.-Y.; Zhou, Z.; Zhu, Z.; Wen, P.; Dai, D.; Zeng, X.; Zhang, K.-M.; Guo, Y.; Sun, Z.-A.; Xia, H.; Ren, Z.; Cakmak, Y. O.; Zhang, M.; Xu, F.; Qu, L.; Zhu, Q.; Lau, P.-M.; Xu, C.; Bi, G.-Q.
10.1101/2025.01.22.632569 — neuroscience — Posted on 2025-01-24
1353 AAV-Delivered Anti-PC-OxPL Antibody Fragments: A NovelTherapeutic Approach to Target ALS
Gomes-Duarte, A.; Wong, J. K.; Pasteuning-Vuhman, S.; Pos, W.; Haselberg, R.; Sogorb-Gonzalez, M.; Pascoal, S.; van Dijk, R.; Sharifi, F.; Giera, M.; Konstantinova, P. S.; Tsimikas, S.; Sadiq, S. A.; van Deventer, S.
10.1101/2025.01.22.634350 — neuroscience — Posted on 2025-01-24
1354 Macrophage depletion restores the DRG microenvironment and prevents axon degeneration in bortezomib-induced neuropathy
Thomsen, M. B.; Singh, A.; Thebeau, C. N.; Gao, V. D.; Schulze, N. F.; Avraham, O.; Yang, S. X.; Koneru, S.; Geier, S. S.; Landon, S. M.; Pelea, A.; Cavalli, V.; Geisler, S.
10.1101/2025.01.22.634362 — neuroscience — Posted on 2025-01-24
1357 Alfalfa transcriptomic responses to the field pathobiome
Nemchinov, L. G.; Irish, B. M.; Grinstead, S.; Postnikova, O. A.
10.1101/2025.01.21.634162 — plant biology — Posted on 2025-01-24
1360 Investigating the role of stomatal dynamics on agronomic traits using a slac1-2 Zea mays mutant
Twohey, R. J.; Christenson, C. G.; Li, C.; Bacher, H.; Calleja, S.; Pastor, B.; Hanneman, M.; Wickes-Do, L.; Gore, M. A.; Pauli, D.; Moose, S. P.; Studer, A. J.
10.1101/2025.01.21.634166 — physiology — Posted on 2025-01-24
1361 B7-H3 as a Dual Clinically Relevant Checkpoint and Antibody Drug Conjugate Target Expressed Across Adenocarcinoma and Neuroendocrine Prostate Cancers
Sharma, S.; Mundhara, N.; Tekoglu, E.; Amaral, A.; Lotan, T. L.; Gu, P.; Luo, J.; Baraban, E. G.; Lack, N. A.; Shenderov, E.
10.1101/2025.01.21.632253 — cancer biology — Posted on 2025-01-24
1363 Proteomic Analysis of Breast Cancer Subtypes Identifies Stromal Contributions that Dictate Aggressive Malignant Behavior
Burton, J. B.; Gascard, P.; Pan, D.; Bons, J.; Bai, R.; Chen-Tanyolac, C.; Caruso, J. A.; Hunter, C.; Schilling, B.; Tlsty, T. D.
10.1101/2025.01.21.634187 — cancer biology — Posted on 2025-01-24
1364 A Domain-Specific Language Model Approach for Identifying Immunogenic Epitopes from Publicly Available Data: EpitopeMiner
Tan, W. K.; Tang, W. L.; Chadha, A. S.; Niedu, R.; Lee, W.; Lim, J. Q.; Rajapakse, M. P.; Wilson, S.; Duan, K.; Chong, R. W. L.; Ong, C. K.; Lee, B.; Rotzschke, O.; Lau, M. C.
10.1101/2025.01.21.633814 — cancer biology — Posted on 2025-01-24
1365 Tunable fluorogenic DNA probes drive fast and high-resolution single-molecule fluorescence imaging
Kummerlin, M.; Zhao, Q.; Hazra, J.; Hepp, C.; Farrar, A.; Turner, P.; Kapanidis, A.
10.1101/2025.01.21.634148 — biophysics — Posted on 2025-01-24
1368 Unveiling Hidden Microbial Diversity in Mars2020 Mission Assembly Cleanrooms withMolecular Insights into the Persistent andPerseverance of Novel Species DefyingMetagenome Sequencing
Muthamilselvi Sivabalan, S. K.; Vijayakumar, V.; Sengupta, P.; Palmal, S.; Krishnamurthi, S.; Kumar Singh, N.; Kyrpides, N. C.; Raman, K.; Venkateswaran, K.
10.1101/2025.01.21.633868 — genomics — Posted on 2025-01-24
1372 Genomic connectivity and adaptation signals of the freshwater sponge Ephydatia muelleri across its distribution
Cassidy, R.; de la Cruz, L.; Mitsi, K.; Galia-Camps, C.; Lopez, A. B.; Gracia-Sancha, C.; Lorente-Sorolla, J. M.; Alvarez-Fernandez, A.; Mozo, R.; Kolomyjec, S. H.; Nichols, S. A.; Manconi, R.; Pereira, R.; Evans, K.; Itskovitch, V.; Horton, A. L.; Leys, S. P.; Taboada, S.; Riesgo, A.
10.1101/2025.01.21.634144 — evolutionary biology — Posted on 2025-01-24
1373 A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis
Darbousset, R.; Senkpeil, L.; Kuehn, J.; Balu, S.; Miglani, D.; Dillon, E.; Fromson, C.; Elahee, M.; Jarrot, P.-A.; Montesi, S. B.; Rao, D. A.; Ware, J.; Wagner, D. D.; Bujor, A. M.; Gutierrez-Arcelus, M.; Nigrovic, P. A.
10.1101/2025.01.21.634123 — immunology — Posted on 2025-01-24
1374 Blockade of mTOR ameliorates IgA Nephropathy by correcting CD89 and CD71 dysfunctions in humanized mice
Cambier, A.; Da Silva, J.; Bex, J.; Canesi, F.; Lachize, L.; Sannier, A.; Boedec, E.; Badie, A.; Monteiro, R. C.
10.1101/2025.01.21.634071 — immunology — Posted on 2025-01-24
1375 Multifaceted Actions of Neurosteroids
Kumar, A.; Qian, M.; Xu, Y.; Benz, A.; Covey, D. F.; Zorumski, C. F.; Mennerick, S.
10.1101/2025.01.22.634297 — neuroscience — Posted on 2025-01-24
1378 Condensin II mediates efficient chromatid resolution and resistance to genotoxic stress in Arabidopsis
Vladejic, J.; Prochazkova, K.; Tomastikova, E. D.; de Cock, Z.; Zwyrtkova, J.; Kaduchova, K.; Pavlikova, M.; Pecinka, A.
10.1101/2025.01.21.634090 — plant biology — Posted on 2025-01-24
1380 Assessing the impact of yield plasticity on hybrid performance in maize
Davis, J. M.; Coffey, L. M.; Turkus, J.; Lopez-Corona, L.; Linders, K.; Ullagaddi, C.; Santra, D. K.; Schnable, P. S.; Schnable, J. C.
10.1101/2025.01.21.634104 — plant biology — Posted on 2025-01-24
1381 Enhancing tree seed germination prediction with image-driven machine learning models.
Barreiro, P. G.; Richard-Bollans, A.; Mattana, E.; Seal, C. E.; Chapman, T.; Dayrell, R.
10.1101/2025.01.21.634084 — plant biology — Posted on 2025-01-24
1382 Human milk bacteria assembled into functionally distinct synthetic communities in infant formula differently affect intestinal physiology and microbiota in neonatal mini-piglets
Le Bras, C.; Randuineau, G.; Cahu, A.; Dahirel, P.; Guerin, S.; Janvier, R.; Rome, V.; Rault, L.; Maillard, M.-B.; Bellanger, A.; Le Loir, Y.; Blat, S.; Even, S.; Le Huerou-Luron, I.
10.1101/2025.01.21.634066 — physiology — Posted on 2025-01-24
1385 Impact of infusion conditions and anesthesia on CSF tracer dynamics in mouse brain
Zhu, Y.; Zhu, J.; Ni, C.; Chen, A.; Li, L.; Gao, Y.; Shoffstall, A. J.; Yu, X.
10.1101/2025.01.21.634133 — physiology — Posted on 2025-01-24
1387 The Lipidome Landscape of Amiodarone Toxicity: An in vivo Lipid-centric Multi-Omics Study
Thu, N. Q.; Oh, J.-H.; Tien, N. T. N.; Park, S.-M.; Yen, N. T. H.; Phat, N. K.; Hung, T. M.; Nguyen, H. T.; Nguyen, D. N.; Yoon, S.; Kim, D. H.; Long, N. P.
10.1101/2025.01.21.633980 — pharmacology and toxicology — Posted on 2025-01-24
1388 Early Proteasome Gene Downregulation And Impaired Proteasomes Function Underlie Proteostasis Failure In Alzheimer's Disease
Myeku, N.; Jiang, S.; Srikanth, M.; Sherpe, R.; Yavari, S.; Gaur, P.; Collins, G. A.; SONI, R.; Menon, V.
10.1101/2025.01.21.634128 — pathology — Posted on 2025-01-24
1389 Druggable genome CRISPRi screen in 3D hydrogels reveals regulators of cortactin-driven actin remodeling in invading glioblastoma cells
Hu, M.; Weldy, A.; Lovalvo, I.; Akins, E.; Jain, S.; Chang, A.; Sati, A.; Lad, M.; Lui, A.; Rajidi, A.; Kothekar, A.; Ding, E. A.; Kumar, S.; Aghi, M. K.
10.1101/2025.01.20.633978 — cancer biology — Posted on 2025-01-24
1390 High cholesterol increases myeloma tumour burden and promotes resistance to bortezomib
Gamez, B.; Whipp, D.; Rao, S. R.; Morris, E. V.; Park, Y. E.; Kaya, Z.; Edwards, C. M.
10.1101/2025.01.21.633916 — cancer biology — Posted on 2025-01-24
1392 Proof-of-principle of NF1 Gene Therapy in plexiform neurofibroma mice models
Bostanthirige, D. H.; Plante, C.; Vatasescu, J.-P. S.; Levesque, M.; Poirier, C.; Deschenes, M.; Chabot, B.; Laurent, B.; Geha, S.; Brosseau, J.-P.
10.1101/2025.01.21.634081 — cancer biology — Posted on 2025-01-24
1393 DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls.
Dennis, S. R.; Tsukioki, T.; Cottone, G.; Zhou, W. R.; Ganz, P. A.; Sehl, M. E.; Luo, Y.; Khan, S. A.; Clare, S. E.
10.1101/2025.01.21.634106 — cancer biology — Posted on 2025-01-24
1400 LEVERAGING TRANSFER LEARNING FOR HIGH-ACCURACY PHENOTYPIC SCREENING IN ZEBRAFISH IMAGE ANALYSIS
Jayaraman, V. U.; Medishetti, R.; Ghosh, S.; Chatti, K.; Uppada, M. K.; Oruganti, S.
10.1101/2025.01.21.634041 — bioinformatics — Posted on 2025-01-24
1405 Genomic reconstruction of Bacillus anthracis from complex environmental samples enables high throughput identification and lineage assignment in Pakistan
Podowski, J. C.; Forrester, S.; Yaqub, T.; Aqel, A.; Abu-Lubad, M.; Mukhtar, N.; Aziz, M. W.; Sardar, N.; Bin Aslam, H.; Pervaiz, H.; Wolfe, A. J.; Schabacker, D.
10.1101/2025.01.21.634099 — bioinformatics — Posted on 2025-01-24
1406 From Background to Signal: Simultaneously derived Copy Numbers from Methylation-Dependent Sequencing cell-free DNA
Hazelaar, D. M.; Boers, R. G.; Boers, J. B.; de Weerd, V.; Jansen, M. P.; Verheul, H. M.; Verhoef, C.; Gribnau, J.; Martens, J. W.; Makrodimitris, S.; Wilting, S. M.
10.1101/2025.01.21.633371 — bioinformatics — Posted on 2025-01-24
1408 ERGA-BGE genome of Androsace saussurei Dentant, Lavergne, F. C. Boucher & S. Ibanez, a recently described plant from the rooftops of Europe
Lavergne, S.; Rosa, A.; Peng, C.; Monteiro, R.; Böhne, A.; Marcussen, T.; Struck, T.; Oomen, R. A.; Genoscope, S. T. T.; Moussy, A.; Cruaud, C.; Labadi, K.; Teodori, E.; Demirdjian, L.; Wincker, P.; Oliveira, P. H.; Aury, J.-M.; Brown, T.
10.1101/2025.01.21.634019 — genomics — Posted on 2025-01-24
1410 Cell type-specific eQTL detection from single-cell RNA-seq reveals post-transcriptional regulatory mechanisms in human islets
de Winter, T. J.; Sovrovic, M.; Dekker, E.; de Graaf, N.; Sun, H.; Johnson, J. D.; Gloyn, A. L.; Carlotti, F.; de Koning, E. J.; Alemany, A.
10.1101/2025.01.21.633530 — genetics — Posted on 2025-01-24
1411 Lethal effects of phyllosphere fungi associated with local plants on invasive plant Ageratina adenophora seedlings
Zeng, Z.-Y.; Liu, Z.-Q.; Yang, A.-L.; Li, Y.-X.; Wang, Y.-L.; Siemann, E.; Li, B.; Zhang, H.-B.
10.1101/2025.01.21.634076 — ecology — Posted on 2025-01-24
1415 Loss of Fanconi anemia proteins causes a reliance on lysosomal exocytosis
Fu, B. X. H. X. H.; Xu, A.; Li, H.; Grandis, J. R.; Johnson, D. E.; Gilbert, L.
10.1101/2025.01.23.634631 — cell biology — Posted on 2025-01-24
1416 Mitochondrial ATP-Sensitive K+ Channels (MitoKATP) Regulate Brown Adipocyte Differentiation and Metabolism
Pereira, O. R.; Serna, J. D. C.; Caldeira da Silva, C. C.; Camara, H.; Kodani, S. D.; Festuccia, W. T.; Tseng, Y.-H.; Kowaltowski, A. J.
10.1101/2025.01.21.634060 — physiology — Posted on 2025-01-24
1417 Sex Hormone Binding Globulin Controls Gender Specific Lipolytic Activity in Human Abdominal Subcutaneous Adipocytes
Abildgaard, J.; Palani, N. P.; Henriksen, T. I.; Aleliunaite, A.; Horvath, C.; Svenstrup, V.; Frederiksen, H.; Juul, A.; Scheele, C.; Pedersen, B. K.; Nielsen, S.
10.1101/2025.01.21.634039 — physiology — Posted on 2025-01-24
1418 Sex-specific transcriptome similarity networks elucidate comorbidity relationships
Sanchez-Valle, J.; Flores-Rodero, M.; Xavier Costa, F.; Carbonell-Caballero, J.; Nunez-Carpintero, I.; Tabares-Seisdedos, R.; Rocha, L. M.; Cirillo, D.; Valencia, A.
10.1101/2025.01.22.634077 — bioinformatics — Posted on 2025-01-24
1419 Generative modeling for RNA splicing predictions and design
Wu, D.; Maus, N.; Jha, A.; Yang, K.; Wales-McGrath, B. D.; Jewell, S.; Tangiyan, A.; Choi, P.; Gardner, J. R.; Barash, Y.
10.1101/2025.01.20.633986 — bioinformatics — Posted on 2025-01-24
1424 Patching up the nucleus: a novel role for PMLII in nuclear envelope rupture repair
Janssen, A. F.; Knowles, O.; Britton, S.; Deane, J. E.; Spruijt, E.; Larrieu, D.
10.1101/2025.01.24.634656 — cell biology — Posted on 2025-01-24
1425 Human milk oligosaccharide metabolism by Clostridium species suppresses inflammation and pathogen growth
Chapman, J. A.; Masi, A. C.; Beck, L. C.; Watson, H.; Young, G. R.; Browne, H. P.; Shao, Y.; Kiu, R.; Nelson, A.; Doyle, J. A.; Palmowski, P.; Lengyel, M.; Connolly, J. P. R.; Lamb, C. A.; Porter, A.; Lawley, T. D.; Hall, L. J.; Embleton, N. D.; Perry, J. D.; Berrington, J. E.; Stewart, C. J.
10.1101/2025.01.21.633585 — microbiology — Posted on 2025-01-24
1426 Innate Immune Memory is Stimulus Specific
O'Farrell, A.; Niu, Z.; Li, J.; Van Eyndhoven, L. C.; Sarma, K.; Raj, A.
10.1101/2025.01.22.634275 — immunology — Posted on 2025-01-24
1427 Humans progressively feel agency over events triggered before their actions
Toma, M.; Mattout, J.; Quentin, R.; Rassoulou, F.; Gautier, A.; Maby, E.; Vernet, M.
10.1101/2023.12.01.569449 — neuroscience — Posted on 2025-01-24
1429 Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity
Pimenta, E. M.; Garza, A. E.; Camp, S. Y.; Park, J.; Hoffman, S. E.; Valderrabano, L.; Fu, J.; Bi, K.; Karam, J.; Titchen, B. M.; Khandekar, M. J.; Shannon, E.; Kang, Y. J.; Nag, A.; Thorner, A. R.; Raut, C. P.; Hornick, J. L.; Merriam, P.; Solimini, N. L.; Demetri, G. D.; Van Allen, E. M.
10.1101/2025.01.20.633920 — cancer biology — Posted on 2025-01-24
1430 BiaPy: Accessible deep learning on bioimages
Franco-Barranco, D.; Andres-San Roman, J. A.; Hidalgo-Cenalmor, I.; Backova, L.; Gonzalez-Marfil, A.; Caporal, C.; Chessel, A.; Gomez-Galvez, P.; Escudero, L. M.; Wei, D.; Munoz-Barrutia, A.; Arganda-Carreras, I.
10.1101/2024.02.03.576026 — bioinformatics — Posted on 2025-01-24
1431 Targeted decontamination of sequencing data with CLEAN
Lataretu, M.; Krautwurst, S.; Huska, M. R.; Marquet, M.; Viehweger, A.; Braun, S. D.; Brandt, C.; Hölzer, M.
10.1101/2023.08.05.552089 — bioinformatics — Posted on 2025-01-24
1434 Protein corona formed on lipid nanoparticles compromises delivery efficiency of mRNA cargo
Voke, E.; Arral, M.; Squire, H. J.; Lin, T.-J.; Coreas, R.; Lui, A.; Iavarone, A. T.; Pinals, R. L.; Whitehead, K. A.; Landry, M.
10.1101/2025.01.20.633942 — bioengineering — Posted on 2025-01-24
1435 First genomic resource of Candidatus Phytoplasma pyri associated to pear decline
Alessio, F. I.; Bongiorno, V. A.; von Backz, O. H.; Conci, L. R.; Fernandez, F. D.
10.1101/2025.01.23.634465 — genomics — Posted on 2025-01-24
1438 Comparative spatial transcriptomics of hair follicle-T cell interactions in mouse, dog and human reveals conserved drivers of primary cicatricial alopecia
Yildiz-Altay, U.; Adhanom, R.; Abdi, W.; Romasco, A.; You, L.; Santacruz, E.; Shakiba, S.; Daga, M.; Tang, Q.; Olivera, M.; Cicuto, T.; Bretheau, F.; Baer, C.; Arjomandnejad, M.; Keeler, A.; Bui, H.; Shokrani, B.; Almela, R.; Byrd, A.; Frey, C.; Richmond, J.
10.1101/2025.01.20.633953 — immunology — Posted on 2025-01-24
1441 Aging directs the differential evolution of KRAS-driven lung adenocarcinoma
Lazure, F.; Drapela, S.; Liu, X.; Lockhart, J.; Kashfi, H.; Sarigul, N.; Ilter, D.; Flores, E. R.; Wang, X.; Smalley, I.; Jaeger, A.; Yu, X.; Gomes, A. P.
10.1101/2025.01.20.633951 — cancer biology — Posted on 2025-01-24
1445 Who am I? Optimal Tissue for Germline Genetic Testing Post-Stem Cell Transplantation
Mertens, M.; Sadlo, M.; Kuehl, J. S.; Metzeler, K.; Zschenderlein, L.; Edelmann, J.; Lehmann, C.; Tull, S.; Karakaya, M.; Velmans, C.; Tumewu, T.; Boehme, M.; Kloetzer, C.; Weigert, A.; Hentschel, J.; Mertens, M.
10.1101/2025.01.20.630521 — genetics — Posted on 2025-01-24
1447 T cell-derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses
Sala, E.; Nelli, M.; Laura, C.; Di Lucia, P.; Beccaria, C. G.; Bono, E. B.; Mangione, M.; Marotta, D.; Sperto, V.; Grillo, M.; Giustini, L.; Tosi, F.; Nie, J.; Kim, D.; Furiato, G.; Malpighi, C.; Consolo, E.; Becher, B.; David, E.; Cohen, M.; Giladi, A.; Amit, I.; Bosselut, R.; Guidotti, L. G.; Iannacone, M.; Kuka, M.
10.1101/2024.12.31.630815 — immunology — Posted on 2025-01-24
1448 Diversity and functional specialization of oyster immune cells uncovered by integrative single cell level investigations
De La Forest Divonne, S.; Pouzadoux, J.; Romatif, O.; Montagnani, C.; Mitta, G.; Destoumieux-Garzon, D.; Gourbal, B.; Charriere, G. M.; Vignal, E.
10.1101/2024.07.19.604245 — immunology — Posted on 2025-01-24
1451 Bridging polarities in metabolomics: Cross-ionization mode chemical similarity prediction between tandem mass spectra
de Jonge, N. F.; Chekmeneva, E.; Schmid, R.; Joas, D.; Truong, L.-J.; van der Hooft, J. J. J.; Huber, F.
10.1101/2024.03.25.586580 — bioinformatics — Posted on 2025-01-24
1453 Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods
Lin, W.-Y.; Kartawinata, M.; Jebson, B. R.; Restuadi, R.; Peckham, H.; Radziszewska, A.; Deakin, C.; Ciurtin, C.; CLUSTER Consortium, ; Wedderburn, L. R.; Wallace, C.
10.1101/2023.09.11.556650 — bioinformatics — Posted on 2025-01-24
1454 PAV-spotter: using signal cross-correlations to identify Presence/Absence Variation in target capture data
de Visser, M. C.; Ploeg, C. v. d.; Cvijanovic, M.; Vucic, T.; Theodoropoulos, A.; Wielstra, B.
10.1101/2024.10.25.620064 — bioengineering — Posted on 2025-01-24
1457 Incomplete recombination suppression fuels extensive haplotype diversity in a butterfly color pattern supergene
De-Kayne, R.; Gordon, I. J.; Terblanche, R. F.; Collins, S.; Omufwoko, K. S.; Martins, D. J.; Martin, S. H.
10.1101/2024.07.26.605145 — evolutionary biology — Posted on 2025-01-24
1458 Mitochondrial ROS and HIF-1α signalling mediate critical period plasticity
Sobrid-Camean, D.; Coulson, B.; Miller, M.; Oswald, M. C.; Pettini, T.; Baines, R. A.; Landgraf, M.
10.1101/2024.11.22.624842 — developmental biology — Posted on 2025-01-24
1459 A trade-off between stress resistance and tolerance underlies the adaptive response to hydrogen peroxide
Jacquel, B.; Kavcic, B.; Aspert, T.; Kuehn, A.; Zhuralev, A.; Byckov, E.; Matifas, A.; Morgan, B.; Julou, T.; Charvin, G.
10.1101/2021.04.23.440814 — cell biology — Posted on 2025-01-24
1460 An Interbacterial Cysteine Protease Toxin Inhibits Cell Growth by Targeting Type II DNA Topoisomerases GyrB and ParE
Song, P.-Y.; Tsai, C.-E.; Chen, Y.-C.; Huang, Y.-W.; Chen, P.-P.; Wang, T.-H.; Hu, C.-Y.; Chen, P.-Y.; Ku, C.; Hsia, K.-C.; Ting, S.-Y.
10.1101/2024.12.30.630690 — microbiology — Posted on 2025-01-24
1462 Human milk oligosaccharide metabolism by Clostridium species suppresses inflammation and pathogen growth
Chapman, J. A.; Masi, A. C.; Beck, L. C.; Watson, H.; Young, G. R.; Browne, H. P.; Shao, Y.; Kiu, R.; Nelson, A.; Doyle, J. A.; Palmowski, P.; Lengyel, M.; Connolly, J. P. R.; Lamb, C. A.; Porter, A.; Lawley, T. D.; Hall, L. J.; Embleton, N. D.; Perry, J. D.; Berrington, J. E.; Stewart, C. J.
10.1101/2025.01.21.633585 — microbiology — Posted on 2025-01-24
1465 Predicting antimicrobial class specificity of small molecules using machine learning
Gadiya, Y.; Genilloud, O.; Bilitewski, U.; Broenstrup, M.; von Berlin, L.; Attwood, M.; Gribbon, P.; Zaliani, A.
10.1101/2024.12.02.626313 — bioinformatics — Posted on 2025-01-24
1468 Ecologically and economically sustainable level of timber harvesting in boreal forests - defining the safe operating space for forest use
Mönkkönen, M.; Blattert, C.; Cours, J.; Duflot, R.; Elo, M.; Eyvindson, K.; Kouki, J.; Trivino, M.; Burgas, D.
10.1101/2024.06.27.600997 — ecology — Posted on 2025-01-24
1474 Dissecting pOXA-48 fitness effects in clinical enterobacteria using plasmid-wide CRISPRi screens
Calvo-Villamanan, A.; Sastre-Dominguez, J.; Barrera-Martin, A.; Costas, C.; San Millan, A.
10.1101/2025.01.23.633114 — microbiology — Posted on 2025-01-24
1475 High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
Howard, C. J.; Abell, N. S.; Osuna, B. A.; Jones, E. M.; Chan, L. Y.; Chan, H.; Artis, D. R.; Asfaha, J. B.; Bloom, J. S.; Cooper, A. R.; Liao, A.; Mahdavi, E.; Mohammed, N.; Su, A. L.; Uribe, G. A.; Kosuri, S.; Dickel, D. E.; Lubock, N. B.
10.1101/2024.10.11.617882 — synthetic biology — Posted on 2025-01-24
1480 Measuring the Strength of Spatial Sorting
Goel, N.; Comerford, M. S.; Bernat, A.; Egan, S. P.; Juenger, T. E.; Keitt, T. H.
10.1101/2025.01.17.633577 — evolutionary biology — Posted on 2025-01-24
1481 Differential regulation of histone H1 subtypes by N6-methyladenosine RNA methylation.
Garcia-Gomis, D.; Lopez-Gomez, J.; Andres, M.; Serna-Pujol, N.; Ponte, I.; Jordan, A.; Roque, A.
10.1101/2025.01.22.634368 — molecular biology — Posted on 2025-01-24
1482 Infection with gut parasites correlates with gut microbiome diversity across human populations in Africa
Ngwese, M. M.; Adegbite, B. R.; Zinsou, J. F.; Fitzstevens, J. L.; Schmidt, V. T.; Moure, P. A. N.; Maloum, M. N.; Tyakht, A. V.; Huus, K. E.; Youngblut, N. D.; Kremsner, P. G.; Akim, A. A.; Ley, R. E.
10.1101/2025.01.23.634469 — microbiology — Posted on 2025-01-24
1483 A trans-amplifying mRNA vaccine with consensus spike elicits broadly cross-neutralizing antibody response against multiple SARS-CoV-2 variants
Gontu, A.; Misra, S.; Chothe, S. K.; Ramasamy, S.; Jakka, P.; Byukusenge, M.; LaBella, L. C.; Nair, M. S.; Jayarao, B. M.; Archetti, M.; Nissly, R. H.; Kuchipudi, S. V.
10.1101/2025.01.22.634352 — microbiology — Posted on 2025-01-24
1484 Clonal interference and changing selective pressures shape the escape of SARS-CoV-2 from hundreds of antibodies
Haddox, H. K.; Abdel Aziz, O.; Galloway, J. G.; Kent, J.; Cooper, C. R.; Bloom, J. D.; Matsen, F. A.
10.1101/2025.01.22.634135 — microbiology — Posted on 2025-01-24
1488 Unravel the start element and promoter architecture across the domain Bacteria
Kuo, S.-T.; Chang, J. K.; Chang, C.; Shen, W.-Y.; Hsu, C.; Lai, S.-W.; Chou, H.-H. D.
10.1101/2025.01.23.634641 — microbiology — Posted on 2025-01-24
1491 Old World alphaviruses use distinct mechanisms to infect brain microvascular endothelial cells for neuroinvasion
Alvarez, P. A.; Tang, A.; Winters, D. M.; Kaushal, P.; Medina, A.; Kaczor-Urbanowicz, K. E.; Ramirez Reyes, B.; Kaake, R. M.; Fregoso, O. I.; Pyle, A. D.; Bouhaddou, M.; Tang, H.; Li, M. M.
10.1101/2025.01.22.634395 — microbiology — Posted on 2025-01-24
1492 South African brown locusts, Locustana pardalina, hosts fluconazole resistant Candidozyma (Candida) auris (Clade III)
Ogundeji, A.; Bello-Akinosho, M.; Swart, V.; Featherston, J.; Bolsenbroek, A.; Beneke, C.; Musoke, J.; Baker, T.; Ismail, A.; Sebolai, O.; Albertyn, J.; Pohl, C.
10.1101/2025.01.22.634428 — microbiology — Posted on 2025-01-24
1494 Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus
Torii, S.; Lord, J. S.; Lavina, M.; Prot, M.; Lecuyer, A.; Diagne, C. T.; Faye, O.; Faye, O.; Sall, A. A.; Bonsall, M. B.; Simon-Loriere, E.; Montagutelli, X.; Lambrechts, L.
10.1101/2025.01.23.634482 — microbiology — Posted on 2025-01-24
1495 DMEM and EMEM are suitable surrogate media to mimic host environment and expand leptospiral pathogenesis studies using in vitro tools
Garcia, L.; Lin, Z.; Culos, S.; Muenker, M. C.; Johnson, E. E.; Wang, Z.; Lopez-Giraldez, F.; Giraud-Gatineau, A.; Jackson, A.; Picardeau, M.; Goodlett, D. R.; Townsend, J. P.; Petrosova, H.; Wunder, E. A.
10.1101/2025.01.22.634353 — microbiology — Posted on 2025-01-24
1496 Malaria vector diversity, transmission, and insecticide resistance, in island communities along the Volta Lake in southern Ghana.
Ebuako, A. A.; Owusu-Asesnso, C. M.; Sabtui, A. R. M.; Sraku, I. K.; Akuamoah-Boateng, Y.; Appiah-Kwarteng, C.; Forson, A. O.; Ayeh-Kumi, P. F.; Afrane, Y. A.
10.1101/2025.01.23.634470 — microbiology — Posted on 2025-01-24
1498 Genetic Determinants of pOXA-48 Plasmid Maintenance and Propagation in Escherichia coli
Baffert, Y.; Fraikin, N.; Makhloufi, Y.; Baltenneck, J.; Val, M.-E.; Dedieu-Berne, A.; degosserie, J.; Iorga, B. I.; Bogaerts, P.; Gueguen, E.; Lesterlin, C.; Bigot, S.
10.1101/2025.01.23.634512 — microbiology — Posted on 2025-01-24
1500 The microbiome of the human facial skin is unique compared to that of other hominids
Degregori, S.; Manus, M.; Qu, E.; Mendall, C.; Baker, J.; Hopper, L.; Amato, K. R.; Lieberman, T.
10.1101/2025.01.22.634396 — microbiology — Posted on 2025-01-24
1502 Convergent Agonist and Heat Activation of Nociceptor TRPM3
Du, J.; Lu, W.; Kumar, S.; Jin, F.; Park, S. J.; Keuning, S. I.; Massimino, R. P.; Choi, W.; Vu, S.
10.1101/2025.01.23.634542 — biophysics — Posted on 2025-01-24
1503 Complex Water Networks Visualized through 2.2-2.3 Angstrom Cryogenic Electron Microscopy of RNA
Kretsch, R. C.; Li, S.; Pintilie, G.; Palo, M. Z.; Case, D. A.; Das, R.; Zhang, K.; Chiu, W.
10.1101/2025.01.23.634578 — biophysics — Posted on 2025-01-24
1504 A single dimer of the SARS-CoV-2 N protein can associate with multiple fragments of single-stranded and stem-loop RNAs
Kaneda, N.; Suzuki, L.; Endo, S.; Husna, S. M. A.; Ishikawa, S.; Takahashi, H.; Oikawa, H.; Itoh, Y.; Takahashi, S.
10.1101/2025.01.23.634602 — biophysics — Posted on 2025-01-24
1508 A single-chain antibody-based AID2 system for conditional degradation of GFP-tagged and untagged proteins
Islam, M.; Negishi, T.; Kitamoto, N.; Hatoyama, Y.; Gamo, K.; Hayashi, K.-i.; Kanemaki, M. T.
10.1101/2025.01.21.633519 — bioengineering — Posted on 2025-01-24
1513 Super-resolution microscopy of mitochondrial mRNAs
Stoldt, S.; Maass, F.; Weber, M.; Dennerlein, S.; Ilgen, P.; Gaertner, J.; Canfes, A.; Schweighofer, S. V.; Jans, D. C.; Rehling, P.; Jakobs, S.
10.1101/2025.01.23.634455 — cell biology — Posted on 2025-01-24
1514 Local traveling waves of cytosolic calcium elicited by defense signals or wounding are propagated by distinct mechanisms
Zhang, W.; Kumar, N.; Helwig, J. R.; Hoerter, A.; Iyer-Pascuzzi, A. S.; Umulis, D. M.; Pienaar, E.; Staiger, C. J.
10.1101/2025.01.23.634554 — cell biology — Posted on 2025-01-24
1516 Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes
Taye, N.; Karoulias, S. Z.; Balic, Z.; Wang, L.; Willard, B.; Martin, D.; Richard, D.; Okamoto, A. S.; Capellini, T. D.; Apte, S. S.; Hubmacher, D.
10.1101/2025.01.23.634616 — cell biology — Posted on 2025-01-24
1519 Construction of Multi-Modal Transcriptome-Small Molecule Interaction Networks from High-Throughput Measurements to Study Human Complex Traits
Akbary Moghaddam, V.; Acharya, S.; Schwaiger-Haber, M.; Liao, S.; Jung, W. J.; Thyagarajan, B.; Shriver, L. P.; Daw, E. W.; Saccone, N. L.; An, P.; Brent, M. R.; Patti, G. J.; Province, M. A.
10.1101/2025.01.22.634403 — systems biology — Posted on 2025-01-23
1520 Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells
Sivakumar, S.; Wang, Y.; Goetsch, S. C.; Pandit, V.; Wang, L.; Zhao, H.; Sundarrajan, A.; Armendariz, D. A.; Takeuchi, C.; Nzima, M.; Chen, W.-C.; Dederich, A. E.; El Hayek, L.; Gao, T.; Ghazawi, R.; Gogate, A.; Kaur, K.; Kim, H. B.; McCoy, M.; Niederstrasser, H.; Oura, S.; Pinzon-Arteaga, C. A.; Sanghvi, M.; Schmitz, D. A.; Yu, L.; Zhang, Y.; Zhou, Q.; Kraus, W. L.; Xu, L.; Wu, J.; Posner, B. A.; Chahrour, M. H.; Hon, G. C.; Munshi, N. V.
10.1101/2025.01.21.633969 — genomics — Posted on 2025-01-23
1521 Loss-of-function mutations in ASIP and MC1R are associated with coat color variation in marsupials.
Sauermann, R.; Fancourt, B.; Faulkner, T.; Shute, H.; Reid, D.; Pask, A. J.; Feigin, C. Y.
10.1101/2025.01.22.633987 — genomics — Posted on 2025-01-23
1522 Functional impact of rare variants and sex across the X-chromosome and autosomes
Ungar, R. A.; Li, T.; Vetr, N. G.; Ersaro, N. M.; Battle, A.; Montgomery, S. B.
10.1101/2025.01.23.634570 — genomics — Posted on 2025-01-23
1523 Inverse hourglass pattern of conservation in rodent molar development.
Ganofsky, J.; Estevez-Villar, M.; Mouginot, M.; Moretti, S.; Nyamari, M.; Robinson-Rechavi, M.; Semon, M.; Pantalacci, S.
10.1101/2025.01.23.634446 — evolutionary biology — Posted on 2025-01-23
1524 Early-life paternal relationships predict adult female survival in wild baboons
Jansen, D. A. W. A. M.; Warutere, J. K.; Tung, J.; Alberts, S. C.; Archie, E.
10.1101/2025.01.22.634342 — evolutionary biology — Posted on 2025-01-23
1526 The brain dynamics of congenitally blind people seeing faces with sound
Matusz, P. J. J.; Reich, L.; Stolz, L. A.; Retsa, C.; Tovar, D. A.; Striem-Amit, E. R.; Aggius-Vella, E.; Amedi, A.; Murray, M. M.
10.1101/2025.01.22.634358 — neuroscience — Posted on 2025-01-23
1527 Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration
Rich, A.; Li, Z.; De Simone, A.; Garcia, L.; Janssen, J.; Ando, K.; Ou, J.; Vergassola, M.; Poss, K. D.; Di Talia, S.
10.1101/2025.01.23.634576 — developmental biology — Posted on 2025-01-23
1528 Pancreatic injury induces β-cell regeneration in axolotl
Powell, C. J.; Singer, H. D.; Juarez, A. R.; Kim, R. T.; Payzin-Dogru, D.; Savage, A. M.; Lopez, N. J.; Blair, S. J.; Abouelela, A.; Dittrich, A.; Akeson, S. G.; Jain, M.; Whited, J. L.
10.1101/2025.01.23.634564 — developmental biology — Posted on 2025-01-23
1529 Dynamic activity of Erg promotes aging of the hematopoietic system
Yano, M.; Sugden, W.; Wang, D.; Badalamenti, B.; Cote, P.; Chin, D.; Goldstein, J.; George, S.; Rodrigues-Luiz, G. F.; da Rocha, E. L.; Li, H.; North, T.; Gryder, B.; Rowe, G.
10.1101/2025.01.23.634563 — developmental biology — Posted on 2025-01-23
1530 Exploring GPCR-mediated optogenetic modulation of seizure network in a pig model of Temporal Lobe Epilepsy
Chang, S.-y.; Bar-Or, K. L.; Mivalt, F.; Maltais, D.; Kfir, Y.; Kim, J.; Kim, I.; Hershko, M.; Daily, J.; Swissa, E.; Levi, O.; Yizhar, O.; Eldar, Y.; Worrell, G.
10.1101/2025.01.23.634545 — neuroscience — Posted on 2025-01-23
1531 Hypothalamic Vasopressin Neurons Enable Maternal Thermoregulatory Behaviors
Adahman, Z.; Ooyama, R.; Gashi, D. B.; Medik, Z. Z.; Hollosi, H. K.; Sahoo, B.; Akowuah, N. D.; Riceberg, J. S.; Carcea, I.
10.1101/2025.01.23.634569 — neuroscience — Posted on 2025-01-23
1532 Maturation of Hippocampus-Medial Prefrontal Cortex Projections Defines a Pathway-Specific Sensitive Period for Cognitive Flexibility
Cruz-Sanchez, A.; Abdusalom, A.; Chasiotis, H.; Gugustea, R.; Mumtaz, U.; Hasantash, M.; Anacker, C.; Arruda-Carvalho, M.
10.1101/2025.01.23.634573 — neuroscience — Posted on 2025-01-23
1533 Evaluation of distal facial nerve branches contribution to facial nerve paralysis in rodents
Marin, B. G.; Grant, J. L.; Mei, C.; Tejeda, G.; Taylor, R. R.; Lee, G. M.; Ortega, V. L.; Cozzone, I. G.; Robbio, R. M.; Robbio, T.; Prasad, A.; Gadkaree, S. K.; Dumont, C. M.
10.1101/2025.01.23.634588 — neuroscience — Posted on 2025-01-23
1534 Data-driven denoising in spinal cord fMRI with principal component analysis
Hemmerling, K. J.; Vigotsky, A. D.; Glanville, C.; Barry, R. L.; Bright, M. G.
10.1101/2025.01.23.634596 — neuroscience — Posted on 2025-01-23
1535 Proximity labeling and orthogonal nanobody pulldown (ID-oPD) approaches to map the spinophilin interactome uncover a putative role for spinophilin in protein homeostasis.
Claeboe, E. T.; Blake, K. L.; Shah, N. R.; Morris, C. W.; Hens, B.; Atwood, B. K.; Absalon, S. J.; Mosley, A. L.; Doud, E. H.; Baucum, A. J.
10.1101/2025.01.23.634546 — neuroscience — Posted on 2025-01-23
1536 An Open-Source Joystick Platform for Investigating Forelimb Motor Control, Auditory-Motor Integration, and Value-Based Decision-Making in Head-Fixed Mice
Linares-Garcia, I.; Iliakis, E. A.; Juliani, S. E.; Ramirez, A. N.; Woolley, J.; Diaz-Hernandez, E.; Fuccillo, M. V.; Margolis, D. J.
10.1101/2025.01.23.634598 — neuroscience — Posted on 2025-01-23
1538 Neural variability compresses with increasing belief precision during Bayesian inference
Skowron, A.; Kosciessa, J. Q.; Lorenz, R.; Hertwig, R.; van den Bos, W.; Garrett, D. D.
10.1101/2024.01.11.575180 — neuroscience — Posted on 2025-01-23
1539 A noncanonical polyamine from bacteria antagonizes animal mitochondrial function
Nauta, K. M.; Gates, D. R.; Weiland, M.; Llontop, M. E. M.; Wang, X.; Nguyen, K. P.; Isaguirre, C. N.; Genjdar, M.; Sheldon, R.; Krawczyk, C. M.; Burton, N. O.
10.1101/2024.04.29.591726 — physiology — Posted on 2025-01-23
1542 An updated vocal repertoire of wild adult bonobos (Pan paniscus )
Wegdell, F.; Schamberg, I.; Berthet, M.; Rothacher, Y.; Dellwo, V.; Surbeck, M.; Townsend, S. W.
10.1101/2025.01.23.634282 — animal behavior and cognition — Posted on 2025-01-23
1543 A sperm-oocyte protein partnership required for egg activation in Caenorhabditis elegans
Tsukamoto, T.; Kwah, J. K.; Zweifel, M. E.; Courtemanche, N.; Gearhart, M. D.; Walstrom, K. M.; Jaramillo-Lambert, A.; Greenstein, D.
10.1101/2025.01.23.634539 — developmental biology — Posted on 2025-01-23
1544 Rdh10-mediated Retinoic Acid Signaling Regulates the Neural Crest Cell Microenvironment During ENS Formation
Butler Tjaden, N. E.; Shannon, S. R.; Seidel, C. W.; Childers, M.; Aoto, K.; Sandell, L. L.; Trainor, P.
10.1101/2025.01.23.634504 — developmental biology — Posted on 2025-01-23
1545 Kiwa is a bacterial membrane-embedded defence supercomplex activated by phage-induced membrane changes
Zhang, Z.; Todeschini, T. C.; Wu, Y.; Kogay, R.; Naji, A.; Cardenas Rodriguez, J.; Anandhakrishna, R. M.; Kaganovich, D.; Taylor, D. W.; Bravo, J. P. K.; Teplova, M.; Amen, T.; Koonin, E. V.; Patel, D. J.; Nobrega, F. L.
10.1101/2023.02.26.530102 — microbiology — Posted on 2025-01-23
1546 Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development
Caccavano, A. P.; Vlachos, A.; McLean, N.; Kimmel, S.; Kim, J. H.; Vargish, G.; Mahadevan, V.; Hewitt, L.; Rossi, A. M.; Spineux, I.; Wu, S. J.; Furlanis, E.; Dai, M.; Garcia, B. L.; Wang, Y.; Chittajallu, R.; London, E.; Yuan, X.; Hunt, S.; Abebe, D.; Eldridge, M. A. G.; Cummins, A. C.; Hines, B. E.; Plotnikova, A.; Mohanty, A.; Averbeck, B. B.; Zaghloul, K.; Dimidschstein, J.; Fishell, G.; Pelkey, K. A.; McBain, C. J.
10.1101/2024.01.20.576455 — neuroscience — Posted on 2025-01-23
1547 Functional recovery of adult brain tissue arrested in time during cryopreservation by vitrification
German, A.; Akdas, E. Y.; Fluegel-Koch, C.; Fejtova, A.; Winkler, J.; Alzheimer, C.; Zheng, F.
10.1101/2025.01.22.634384 — neuroscience — Posted on 2025-01-23
1549 Co-Conservation of Synaptic Gene Expression and Circuitry in Collicular Neurons
Liu, Y.; McDaniel, J. A.; Chen, C.; Yang, L.; Kipcak, A.; Savier, E.; Erisir, A.; Cang, J.; Campbell, J. N.
10.1101/2025.01.23.634521 — neuroscience — Posted on 2025-01-23
1553 Homeostatic bidirectional plasticity in Upbound and Downbound micromodules of the olivocerebellar system
Fernandez Santoro, E. M.; Landsmeer, L. P. L.; Hamdioui, S.; Strydis, C.; De Zeeuw, C. I.; Badura, A.; Negrello, M.
10.1101/2025.01.23.634547 — neuroscience — Posted on 2025-01-23
1555 White matter connections of human ventral temporal cortex are organized by cytoarchitecture, eccentricity, and category-selectivity from birth
Kubota, E.; Yan, X.; Tung, S.; Fascendini, B.; Tyagi, C.; Duhameau, S.; Ortiz, D.; Grotheer, M.; Natu, V. S.; Keil, B.; Grill-Spector, K.
10.1101/2024.07.29.605705 — neuroscience — Posted on 2025-01-23
1556 Contrasting contribution of embryo- and postnatally-derived brain-resident macrophages in sustaining sleep-wake circuitry
Seifinejad, A.; Bandarabadi, M.; Haddar, M.; Wundt, S.; Tafti, M.; Vassalli, A.; Khani, A.; Monaco, G.
10.1101/2024.01.22.576653 — neuroscience — Posted on 2025-01-23
1557 The Power of Three: Dynactin associates with three dyneins under load for greater force production
Rao, L.; Liu, X.; Berger, F.; McKenney, R. J.; Arnold, M.; Stengel, K.; Sidoli, S.; Gennerich, A.
10.1101/2025.01.14.632506 — biophysics — Posted on 2025-01-23
1565 Differentiation Success of Reprogrammed Cells is Heterogenous In Vivo and Modulated by Somatic Cell Identity Memory
Zikmund, T.; Fiorentino, J.; Penfold, C. A.; Stock, M.; Shpudeiko, P.; Agarwal, G.; Langfeld, L.; Petrova, K.; Peshkin, L.; Hamperl, S.; Scialdone, A.; Hoermanseder, E.
10.1101/2024.07.05.602198 — developmental biology — Posted on 2025-01-23
1566 Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice
Bruter, A. V.; Varlamova, E. A.; Stavskaya, N. I.; Antysheva, Z. G.; Manskikh, V. N.; Tvorogova, A. V.; Korshunova, D. S.; Khamidullina, A. I.; Utkina, M. V.; Bogdanov, V. P.; Baikova, I. P.; Nikiforova, A. I.; Albert, E. A.; Maksimov, D. O.; Li, J.; Chen, M.; Schools, G. P.; Feoktistov, A. V.; Shtil, A. A.; Roninson, I. B.; Mogila, V. A.; Silaeva, Y. Y.; Tatarskiy, V. V.
10.1101/2023.11.04.564913 — developmental biology — Posted on 2025-01-23
1567 Stratification of enterochromaffin cells by single-cell expression analysis
Song, Y.; Fothergill, L. J.; Lee, K. S.; Liu, B. Y.; Koo, A.; Perelis, M.; Diwakarla, S.; Callaghan, B.; Huang, J.; Wykosky, J.; Furness, J. B.; Yeo, G. W.
10.1101/2023.08.24.554649 — cell biology — Posted on 2025-01-23
1569 Exploiting fluctuations in gene expression to detect causal interactions between genes
Joly-Smith, E.; Talpur, M. M.; Allard, P.; Papazotos, F.; Potvin-Trottier, L.; Hilfinger, A.
10.1101/2023.09.01.555799 — systems biology — Posted on 2025-01-23
1570 Reduced Liver Mitochondrial Energy Metabolism Impairs Food Intake Regulation Following Gastric Preloads and Fasting
Ponte, M. E.; Prom, J. C.; Newcomb, M. A.; Jordan, A. B.; Comfort, L. L.; Hu, J.; Puchalska, P.; Geisler, C. E.; Hayes, M. R.; Morris, E. M.
10.1101/2024.10.24.620086 — physiology — Posted on 2025-01-23
1571 Immune cell mitochondrial phenotypes are largely preserved in mitochondrial diseases and do not reflect disease severity
Liu, C. C.; Kurade, M.; Monzel, A. S.; Kelly, C.; Juster, R.-P.; Trumpff, C.; Hirano, M.; Picard, M.
10.1101/2025.01.18.633635 — pathology — Posted on 2025-01-23
1572 Bridging polarities in metabolomics: Cross-ionization mode chemical similarity prediction between tandem mass spectra
de Jonge, N. F.; Chekmeneva, E.; Schmid, R.; Joas, D.; Truong, L.-J.; van der Hooft, J. J. J.; Huber, F.
10.1101/2024.03.25.586580 — bioinformatics — Posted on 2025-01-23
1577 Motor cortical beta power reflects adaptation to task constraints
Pierrieau, E.; Dussard, C.; Plantey-Veux, A.; Guerrini, C.; Lau, B.; Pillette, L.; George, N.; Jeunet-Kelway, C.
10.1101/2025.01.23.634491 — neuroscience — Posted on 2025-01-23
1578 A phenomenological interpretation of multiple bursting patterns in Lateral Habenula neurons
Fedorov, D.; Campillo, F.; Desroches, M.; Soria-Gomez, E.; Piriz, J.; Rodrigues, S.
10.1101/2025.01.23.634464 — neuroscience — Posted on 2025-01-23
1579 Shallow-angle intracranial cannula for repeated infusion and in vivo imaging with multiphoton microscopy
Hou, S. S.; Yang, J.; Kwon, Y.; Pian, Q.; Tang, Y.; Dauphinais, C. A.; Calvo-Rodriguez, M.; El Khatib, M.; Vinogradov, S. A.; Sakadzic, S.; Bacskai, B. J.
10.1101/2025.01.22.634409 — neuroscience — Posted on 2025-01-23
1583 Inhibition of cytosolic translation mitigates mitochondrial dysfunction in C. elegans
Mallick, A.; Du, Y.; Ramalho, T.; Li, R.; Ali, L.; Kim, S.; Zhu, L. J.; Haynes, C.
10.1101/2025.01.22.634344 — developmental biology — Posted on 2025-01-23
1584 Convergent flow-mediated mesenchymal force drives embryonic foregut constriction and splitting
Yan, R.; Hoffmann, L. A.; Oikonomou, P.; Li, D.; Lee, C.; Gill, H. K.; Mongera, A.; Nerurkar, N.; Mahadevan, L.; Tabin, C. J.
10.1101/2025.01.22.634318 — developmental biology — Posted on 2025-01-23
1587 A synaptic-astrocytic proteomic signature associated with synaptopathy in Alzheimer's Disease
GRIFFITHS, J.; Schneegans, E.; Whitwell, H.; Qiu, Z.; Notman, B.; Cheung, D.; Willumsen, N.; Matthews, P. M.; Grant, S.; Jackson, J.
10.1101/2025.01.23.634408 — neuroscience — Posted on 2025-01-23
1590 Neural signatures for temporal order memory in the macaque medial posterior parietal cortex
Zuo, S.; Wang, C.; Wang, L.; Jin, Z.; Zhou, X.; Su, N.; Liu, J.; McHugh, T.; Kusunoki, M.; Kwok, S. C.
10.1101/2023.08.17.553665 — neuroscience — Posted on 2025-01-23
1591 STExplorer: Navigating the Micro-Geography of Spatial Omics Data
Zormpas, E.; Vlachogiannis, N. I.; Resteu, A.; Unsworth, A.; Tual-Chalot, S.; Dorgau, B.; Queen, R.; Lako, M.; Tiniakos, D.; Comber, A.; Anstee, Q. M.; Giakountis, A.; Cockell, S. J.
10.1101/2025.01.17.633539 — bioinformatics — Posted on 2025-01-23
1593 Cell type-specific immune regulation under symbiosis in a facultatively symbiotic coral
Valadez-Ingersoll, M.; Rivera, H. E.; Da-Anoy, J.; Kanke, M.; Gomez-Campo, K.; Martinez-Rugerio, M. I.; Kwan, J.; Hekman, R.; Emili, A.; Gilmore, T. D.; Davies, S. W.
10.1101/2024.06.20.599951 — genomics — Posted on 2025-01-23
1594 A path analysis disentangling determinants of natal dispersal in a cooperatively breeding bird
Borger, M. J.; Lee, K. G. L.; Weissing, F. J.; Richardson, D. S.; Dugdale, H. L.; Burke, T.; Pen, I.; Komdeur, J.
10.1101/2024.07.26.605387 — ecology — Posted on 2025-01-23
1596 Avian-specific Salmonella transition to endemicity is accompanied by localized resistome and mobilome interaction
Jia, C.; Huang, C.; Zhou, H.; Zhou, X.; Wang, Z.; Siddique, A.; Kang, X.; Cao, Q.; Huang, Y.; He, F.; Li, Y.; Yue, M.
10.1101/2024.07.26.605275 — microbiology — Posted on 2025-01-23
1597 The Spatial Frequency Representation Predicts Category Coding in the Inferior Temporal Cortex
Toosi, R.; Karami, B.; Koushki, R.; Shakerian, F.; Noroozi, J.; Rezayat, E.; Vahabie, A.-H.; Akhaee, M. A.; Dehaqani, M.-R. A.
10.1101/2023.11.07.566068 — neuroscience — Posted on 2025-01-23
1598 Detection and Removal of Hyper-synchronous Artifacts in Massively Parallel Spike Recordings
Oberste-Frielinghaus, J.; Morales-Gregorio, A.; Essink, S.; Kleinjohann, A.; Barthelemy, F.; Musall, S.; Grun, S.; Ito, J.
10.1101/2024.01.11.575181 — neuroscience — Posted on 2025-01-23
1600 Characterizing dog communities adjacents to key shorebird sites in Chile
Contreras, G.; Peredo, R.; Sandvig, E. M.; Rodriguez, B.; Gallardo, B.; Norambuena, H. V.; Medrano, F.
10.1101/2025.01.20.630152 — zoology — Posted on 2025-01-23
1602 Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females
Vantomme, H.; Quiniou, V.; Adda, L.; Jouannet, C.; Mhanna, V.; Albalaa, C.; Barennes, P.; Coatnoan, N.; Diderot, V.; Dubois, J.; Fourcade, G.; Le Gouge, K.; Nguekap Tchoumba, O.; Pezous, M.; Stys, P.; Six, A.; Mariotti Ferrandiz, E.; Klatzmann, D.
10.1101/2025.01.21.633929 — systems biology — Posted on 2025-01-23
1605 Jack of all trades and master of most: Carpobrotus taxa show no trade-off in reproductive strategies
Canavan, S.; Rodriguez, J.; Skalova, H.; Le Roux, J. J.; Brundu, G.; Castillo, M. L.; D'Antonio, C.; Gonzalez, L.; Hulme, P. E.; Richardson, D. M.; McLean, P.; Moodley-Marikova, D.; Moravcova, L.; Parker, I. M.; Pysek, P.; Stajerova, K.; van Wyk, E.; Novoa, A.
10.1101/2025.01.21.634022 — plant biology — Posted on 2025-01-23
1607 Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis
Garcia-Vazquez, N.; Gonzalez-Robles, T. J.; Lane, E.; Spasskaya, D.; Zhang, Q.; Kerzhnerman, M. A.; Jeong, Y.; Collu, M.; Simoneschi, D.; Ruggles, K. V.; Rona, G.; Kaisari, S.; Pagano, M.
10.1101/2024.06.26.600797 — biochemistry — Posted on 2025-01-23
1608 Genomic adaptations to semi-aquatic and aquatic life in spiders
Fan, Z.; Wang, L.-Y.; Luo, B.; Ren, T.-Y.; Gao, J.-X.; Liu, P.; Cheng, L.-X.; Cai, Y.-J.; Tan, B.; Huang, Q.; Deng, M.-Q.; Zuo, Q.; Zhang, X.-Y.; Lu, J.-Z.; Sun, L.-N.; Irfan, M.; Liu, N.; Tong, C.; Bai, M.; Zhang, Z.-S.
10.1101/2024.01.15.575295 — genomics — Posted on 2025-01-23
1609 CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation during cellular differentiation
Karpinska, M. A.; Zhu, Y.; Fakhraei Ghazvini, Z.; Ramasamy, S.; Barbieri, M.; Cao, N. T. B.; Varahram, N.; Aljahani, A.; Lidschreiber, M.; Papantonis, A.; Oudelaar, A. M.
10.1101/2024.11.20.624447 — genomics — Posted on 2025-01-23
1612 A Recessive oca2 Mutation Underlies Albinism in Xiphophorus fish
Xing, Y.; Boswell, W.; Parker, J.; Du, K.; Schartl, M.; Lu, Y.
10.1101/2025.01.20.633999 — genetics — Posted on 2025-01-23
1613 Selection and transmission of the gut microbiome alone shifts mammalian behavior
Suzuki, T. A.; Akbuga-Schon, T.; Waters, J. L.; Jakob, D.; Vu, D. L.; Ballinger, M. A.; Di Rienzi, S. C.; Chang, H.; de Araujo, I. E.; Tyakht, A. V.; Ley, R. E.
10.1101/2025.01.21.634013 — evolutionary biology — Posted on 2025-01-23
1615 Disentangling heritability and plasticity effects on Populus fremontii leaf reflectance across a temperature gradient
Seeley, M. M.; Thomson, E.; Allan, G. J.; Wiebe, B. C.; Whitham, T. G.; Hultine, K.; Cooper, H. F.; Asner, G. P.; Doughty, C. E.
10.1101/2024.10.21.619129 — ecology — Posted on 2025-01-23
1617 ERH Enables Early Embryonic Differentiation and Overlays H3K9me3 Heterochromatin on a Cryptic Pluripotency H3K9me3 Landscape in Somatic Cells
Katznelson, A.; Hernandez, B.; Fahning, H.; Zhang, J.; Burton, A.; Torres-Padilla, M.-E.; Plachta, N.; Zaret, K. S.; McCarthy, R. L.
10.1101/2024.06.06.597604 — developmental biology — Posted on 2025-01-23
1618 Integrative Mapping of Pre-existing Immune Landscapes for Vaccine Response Prediction
Hao, S.; Tomic, I.; Lindsey, B. B.; Jagne, Y. J.; Hoschler, K.; Meijer, A.; Carreno Quiroz, J. M.; Meade, P.; Sano, K.; Peno, C.; Costa Martins, A. G.; Bogaert, D.; Kampmann, B.; Nakaya, H.; Krammer, F.; de Silva, T. I.; Tomic, A.
10.1101/2025.01.22.634302 — immunology — Posted on 2025-01-23
1619 Regionally specific resting-state beta neural power predicts brain injury and symptom recovery in adolescents with concussion: a longitudinal study
Edgar, J. C.; Blaskey, L.; Chen, Y.; Podolak, O. E.; Murray, D. L.; McNamee, M.; Konka, K.; Berman, J. I.; Roberts, T. P. L.; Huang, M.; Arbogast, K. B.; Master, C. L.
10.1101/2025.01.22.633765 — neuroscience — Posted on 2025-01-23
1623 Even if suboptimal, novelty drives human exploration
Modirshanechi, A.; Lin, W.-H.; Xu, H. A.; Herzog, M. H.; Gerstner, W.
10.1101/2022.07.05.498835 — neuroscience — Posted on 2025-01-23
1627 Cell competition confers anchorage plasticity of disseminated tumor cells
Huh, H. D.; Sub, Y.; Kim, J. H.; Lee, H.; Oh, J.; Lee, D. K.; Hwa, B. J.; Pyun, W. Y.; Bae, S. J.; Pak, S.; Lee, H.-C.; Choi, J.; Jeong, J.; Gee, H. Y.; Park, H. W.
10.1101/2024.11.25.625320 — cancer biology — Posted on 2025-01-23
1628 Neoplastic immune mimicry is a generalizable phenomenon in breast cancer and epithelial CD69 enables early tumor progression
Berens, E. B.; Khou, S.; Huang, E.; Hoffman, A.; Johnson, B.; Kirchberger, N.; Sivagnanam, S.; Calistri, N. L.; Derrick, D.; Liby, T. A.; McLean, I. C.; Alanizi, A. A.; Ozmen, F.; Ozmen, T. Y.; Mills, G. B.; Hwang, E. S.; Schedin, P. J.; Gonzalez, H.; Werb, Z.; Heiser, L. M.; Coussens, L. M.
10.1101/2025.01.17.633673 — cancer biology — Posted on 2025-01-23
1630 Antibody Library Design by Seeding Linear Programming with Inverse Folding and Protein Language Models
Hayes, C. F.; Magana-Zook, S. A.; Goncalves, A.; Solak, A. C.; Faissol, D.; Landajuela, M.
10.1101/2024.11.03.621763 — bioinformatics — Posted on 2025-01-23
1632 Focused Ultrasound Augments the Delivery and Penetration of Model Therapeutics into Cerebral Cavernous Malformations
Fisher, D. G.; Hoch, M. R.; Gorick, C. M.; Huchthausen, C.; Breza, V. R.; Sharifi, K. A.; Tvrdik, P.; Miller, G. W.; Price, R. J.
10.1101/2024.08.27.609060 — bioengineering — Posted on 2025-01-23
1634 Gastrula-premarked posterior enhancer primes posterior tissue development through cross-talk with TGF-β signaling pathway
Chen, Y.; Tan, F.; Fang, Q.; Zhang, L.; Liao, J.; Shen, P.; Qian, Y.; Wen, M.; Song, R.; Fu, Y.; Xu, H. J.; Wang, R.; Li, C.; Shao, Z.; Li, J.; Jing, N.; Yang, X.
10.1101/2024.04.14.589453 — developmental biology — Posted on 2025-01-23
1637 Regulation of hematopoietic stem cell (HSC) proliferation by Epithelial Growth Factor Like-7 (EGFL7)
Kulkarni, R.; Goda, C.; Rudich, A.; Karunasiri, M.; Urs, A. P.; Bustos, Y.; Balcioglu, O.; Li, W.; Chidester, S.; Rodgers, K. A.; Garfinkle, E.; Patel, A.; Miller, K. E.; Popovich, P. G.; Elf, S.; Garzon, R.; Dorrance, A. M.
10.1101/2025.01.21.634107 — cell biology — Posted on 2025-01-23
1639 Phase transition of spindle pole localized protein orchestrates nuclear organization at mitotic exit
Rajeevan, A.; Olakkal, V.; Balakrishnan, M.; Chakrabarty, D.; Charon, F.; Noordermeer, D.; Kotak, S.
10.1101/2025.01.22.634232 — cell biology — Posted on 2025-01-23
1642 Optimisation of skeletal muscle sampling for cultured fat production
Dohmen, R. G.; Hueber, R.; Martins, B.; Gouveia, M. A.; Zschieschang, S.; de Vries, M.; Eussen, R.; Caubergh, J.; Post, M. J.; Flack, J. E.
10.1101/2025.01.22.634340 — cell biology — Posted on 2025-01-23
1643 Jk DNA GAGA MOTIFS ARE REQUIRED FOR LOCAL NUCLEOSOME REMODELING AND Vk-Jk RECOMBINATION
Veselits, M.; McLean, K. C.; Wright, N. E.; Veselits, J.; Okoreeh, M.; Maienschein-Cline, M.; Mandal, M.; Clark, M. R.
10.1101/2025.01.21.634169 — cell biology — Posted on 2025-01-23
1644 Characterization of cytotrophoblast cell population dynamics throughout pregnancy
Schäffers, O.; Verburgt, S.; Harhangi, M.; Broekhuizen, M.; van Hengel, E.; van der Meeren, L.; Schoenmakers, S.; Dekkers, D.; Doff, W.; Demmers, J.; Reiss, I.; Gribnau, J.; van Rijn, B.
10.1101/2025.01.22.634235 — cell biology — Posted on 2025-01-23
1645 Treacle's ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair
Velichko, A. K.; Petrova, N. V.; Deriglazov, D. A.; Kovina, A. P.; Luzhin, A. V.; Kazakov, E. P.; Kireev, I. I.; Razin, S. V.; Kantidze, O.
10.1101/2023.05.11.540311 — cell biology — Posted on 2025-01-23
1647 Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
Gao, X.; Guo, W.; Liu, P.; Yuwen, M.; Liu, Z.; Tan, R.; Liu, K.; Yang, Z.; Ba, J.; Bai, X.; Shama, S.; Tang, C.; Miao, K.; Pei, H.; Liu, L.; Zhu, C.; Wang, T.; Zhang, B.; Kang, J.
10.1101/2024.01.06.574490 — cell biology — Posted on 2025-01-23
1648 Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules
Jassinskaja, M.; Bode, D.; Gonka, M.; Roumeliotis, T. I.; Hogg, A. J.; Rubio Lara, J. A.; Bennett, E.; Milek, J.; Theeuwes, B.; Vijayabaskar, M. S.; Cabrera Cosme, L.; Che, J. L. C.; MacDonald, S.; Ahmed, S.; Hall, B. A.; Vasey, G.; Kooi, H.; Belmonte, M.; Shepherd, M. S.; Brackenbury, W. J.; Kucinski, I.; Yamazaki, S.; Holding, A. N.; Cull, A. H.; Wilson, N. K.; Gottgens, B.; Chaudhary, J. S.; Kent, D. G.
10.1101/2025.01.20.633881 — cell biology — Posted on 2025-01-23
1649 The T3SS structural and effector genes of Chlamydia trachomatis are expressed in distinct phenotypic cell forms.
Grieshaber, N.; Appa, C. R.; Ward, M.; Grossman, A.; McCormik, S.; Grieshaber, B. S.; Chiarelli, T. J.; Yang, H.; Omsland, A.; Grieshaber, S. S.
10.1101/2024.04.25.591156 — microbiology — Posted on 2025-01-23
1650 Distinct memory CD4 subset tropism of two CCR5-tropic HIV-1 in a rapid progressor
Marichannegowda, M.; Farah, Y.; Bose, M.; Sanders-Buell, E.; King, D.; Francisco, L.; Eller, L. A.; Tovanabutra, S.; Michael, N. L.; Robb, M. L.; Song, H.
10.1101/2025.01.21.634053 — microbiology — Posted on 2025-01-23
1652 A Shared Neural Network for Highly Liked and Disliked Music
Ripolles, P.; Belfi, A. M.; Kasdan, A.; Vessel, E. A.; Halpern, A. R.; Rowland, J.; Hopkins, R.; Starr, G. G.; Poeppel, D.
10.1101/2025.01.20.633989 — neuroscience — Posted on 2025-01-23
1653 High-throughput evolution of near-infrared oxytocin nanosensors enables oxytocin imaging in mice and prairie voles
Adams, J.; Komatsu, N.; Navarro, N. P.; Leem, E.; Sun, X.; Zhao, J.; Arias-Soto, O.; Landry, M.
10.1101/2024.05.10.593556 — neuroscience — Posted on 2025-01-23
1655 An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome
Thakur, P.; Lackinger, M.; Diamantopoulou, A.; Rao, S.; Chen, Y.; Khalizova, K.; Ferng, A.; Mazur, C.; Kordasiewicz, H.; Shprintzen, R. J.; Markx, S.; Xu, B.; Gogos, J. A.
10.1101/2022.03.01.482495 — neuroscience — Posted on 2025-01-23
1658 Volatile-suppressed peptide signaling enhances volatile responses in plant-plant interactions
Wang, L.; Hoefer, S.; Jimenez-Sandoval, P.; Yu, H.; Spiegelhalder, R.; Waterman, J. M.; Hurni, L.; Hu, L.; Liu, L.; Jackson, D.; Raissig, M.; Erb, M.
10.1101/2025.01.20.634011 — plant biology — Posted on 2025-01-23
1660 ND-13, a DJ-1 derived peptide, as a novel pharmacological approach in the prevention of NLRP3 inflammasome activity in Diabetic Nephropathy
Caballero Herrero, M. J.; Arias Sanchez, C.; Quevedo, I.; S. Latham, P.; Garijo, C. D. M.; Zhong, Y.; Xu, G.; Guillen, E.; Nunez-Sancho, A.; Angosto, D.; Molina Lopez, C.; Hurtado Navarro, L.; Schachter, J.; Pardo Marin, L.; Ceron, J. J.; Hernandez Martinez, A.; Rosique Lopez, F.; Andugar Rocamora, L.; B. Cabezuelo, J.; Pelegrin, P.; Cuevas, S.
10.1101/2025.01.21.633908 — cell biology — Posted on 2025-01-23
1663 Hyperglycemia worsens smooth muscle foam cell formation through PI3Kgamma-dependent defective autophagy
Labrana, H.; Wahart, A.; Cormier, K.; Solinhac, R.; Swiader, A.; Mentouri, I.; Smirnova, N.; Malet, N.; Gayral, S.; Ramel, D.; Auge, N.; Laffargue, M.
10.1101/2025.01.21.634036 — cell biology — Posted on 2025-01-23
1664 GEI-17-Mediated SUMOylation of GDI-1 Regulates Apoptotic Cell Clearance
Xiao, H.; Yuan, L.; Li, P.; Ma, A.; Li, C.; Liu, F.; Xie, Y.; Zheng, Q.; Wang, H.
10.1101/2025.01.22.634223 — cell biology — Posted on 2025-01-23
1665 Symbiont-specific uptake is mediated by integrins in cnidarian larvae
Jones, V. A. S.; Dorr, M.; Siemers, I.; Rupp, S.; Surm, J. M.; Maegele, I.; Gornik, S. G.; Ferguson, M.; Guse, A.
10.1101/2025.01.21.633834 — cell biology — Posted on 2025-01-23
1666 CD271 sorting for improved liver cell isolation: Semiautomated and simultaneous preparation of parenchymal and non-parenchymal cells from mouse and human livers
Dropmann, A.; Dewidar, B.; Gould, K.; Baccetto, R. L.; Meyer, C.; Caccamo, T.; Erdoesi, P.; Ayvaz, S.; Scheffschick, A.; Damm, G.; Seehofer, D.; Feiner, L. K.; Kruse, B.; Rubie, C.; Glanemann, M.; Orth, V.; Birgin, E.; Rahbari, N.; Ebert, M. P.; Dooley, S.; Hammad, S.
10.1101/2025.01.21.633876 — cell biology — Posted on 2025-01-23
1667 Tool-use brain representations are independent of the acting body part and motor experience
Martinez-Addiego, F.; Liu, Y.; Moon, K.; Shytle, E.; Amaral, L.; O'Brien, C.; Sen, S.; Riesenhuber, M.; Culham, J. C.; Striem-Amit, E. R.
10.1101/2025.01.22.634305 — neuroscience — Posted on 2025-01-22
1669 A pivot-tether model for nucleosome recognition by the chromosomal passenger complex
Ruza, R. R.; Chung, C.; Gold, D.; Serena, M.; Roberts, E.; gruneberg, u.; Barr, F.
10.1101/2025.01.22.634029 — cell biology — Posted on 2025-01-22
1670 The RNA-binding protein RSRC2 promotes mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1
Georgieva, K.; Coomer, A. O.; Babaei, P.; Guiducci, G.; Dodel, M.; Maniati, E.; Thind, A.; Krishnamurthy, S.; Nawrocka, A.; Wallis, S. S.; Shkumatava, A.; Wang, J.; Mardakheh, F. K.; Stojic, L.
10.1101/2025.01.21.634161 — cell biology — Posted on 2025-01-22
1671 Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells
Malik, M.; de Leeuw, W.-J.; Aslam, M. A.; Kwesi-Maliepaard, E. M.; van den Brand, T. A.; van den Broek, B.; Kempers, M.; Hoekman, L.; Proost, N.; van Welsem, T.; de Wit, E.; Borst, J.; Jacobs, H.; van Leeuwen, F.
10.1101/2025.01.20.633937 — immunology — Posted on 2025-01-22
1672 Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response
Serrato-Pomar, I.; Zoladek, J.; Medkour, H.; Narpon, Q.; Rey-Cadilhac, F.; Rossi, S.; French, S. A.; Modahl, C.; Sornjai, W.; Miot, E.; Hamel, R.; Mediannikov, O.; Misse, D.; Nisole, S.; Pompon, J.
10.1101/2025.01.21.634113 — immunology — Posted on 2025-01-22
1675 Structural Insights into Immature Dengue Virus-Like Particles Revealed by Cryo-EM and Molecular Dynamics Simulations
Palur, V. R.; Chen, G.-W.; Chao, D.-Y.; Wu, Y.-N.; Galula, J. U.; Wang, C.-H.; Bond, P. J.; Marzinek, J. K.; Wu, S.-R.
10.1101/2025.01.21.631174 — bioinformatics — Posted on 2025-01-22
1676 Genome-wide mapping of the Galleria mellonella larvae transcription start sites during fungal infection and treatment
Abugessaisa, I.; Konings, M.; Manabe, R.-i.; Tagami, M.; Severin, J.; Hasegawa, A.; Kawashima, T.; Kinoshita, H.; Noma, S.; Takahashi, C.; Verbon, A.; Okazaki, Y.; van de Sande, W. W. J.; Kasukawa, T.
10.1101/2025.01.20.627872 — genomics — Posted on 2025-01-22
1677 Single Cell Transcriptome Signatures of Sarcoidosis in Lung Immune Cell Populations
Moore, C.; Liao, S.-Y.; Wood, C.; Sarkar, A.; Cardwell, J.; MacPhail, K.; Mroz, M. M.; Riley, C.; Mould, K.; Restrepo, C.; Li, L.; Maier, L. A.; Yang, I. V.
10.1101/2025.01.20.633917 — genomics — Posted on 2025-01-22
1678 Heat-responsive dynamic shifts in alternative splicing of the coral Acropora cervicornis
Stankiewicz, K. H.; Valenzuela, J. J.; Turkarslan, S.; Wu, W.-J.; Gomez-Campo, K.; Locatelli, N. S.; Conn, T. L.; Radice, V. Z.; Parker, K. E.; Alderdice, R.; Bay, L. K.; Voolstra, C. R.; Barshis, D. J.; Baums, I. B.; Baliga, N. S.
10.1101/2025.01.21.634199 — genomics — Posted on 2025-01-22
1680 Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ
Eislmayr, K. D.; Langner, C.; Liu, F. L.; Yuvaraj, S.; Babirye, J. P.; Roncaioli, J. L.; Vickery, J. M.; Barton, G. M.; Lesser, C. F.; Vance, R. E.
10.1101/2025.01.20.633976 — immunology — Posted on 2025-01-22
1681 PERK orchestrates MERCS formation and mitochondrial remodelling promoting physiological adaptations during adaptive UPR signalling
Casas-Martinez, J. C.; Xia, Q.; Li, P.; Borja-Gonzalez, M.; Miranda-Vizuete, A.; McDermott, E.; Dockery, P.; Quinlan, L.; Goljanek-Whysall, K.; Samali, A.; McDonagh, B.
10.1101/2025.01.20.633960 — cell biology — Posted on 2025-01-22
1682 Glycoprotein 130 Antagonism Counteracts Metabolic and Inflammatory Alterations to Enhance Right Ventricle Function in Pulmonary Artery Banded Pigs
Mendelson, J. B.; Sternbach, J.; Moon, R.; Hartweck, L.; Clark, S.; Tollison, W.; Lahti, M.; Carney, J.; Markowski, T.; Higgins, L.; Kazmirczak, F.; Prins, K.
10.1101/2025.01.20.633954 — physiology — Posted on 2025-01-22
1683 Genomic Analysis of Date Palm Fruit Size Trait and Identification of Candidate Genes through GWAS
Younuskunju, S.; Mohamoud, Y. A.; Suhre, K.; Mathew, L. S.; Mayer, K.; Malek, J. A.
10.1101/2025.01.20.633890 — genomics — Posted on 2025-01-22
1684 Three annotated chromosome-level de novo genome assemblies of Lomentospora prolificans provide evidence for a chromosomal translocation event
Grossman, N. T.; Fan, Y.; Zimin, A. V.; Wear, M. P.; Jedlicka, A.; Dziedzic, A.; Liporagi-Lopes, L.; Timp, W.; Casadevall, A.
10.1101/2025.01.21.634120 — genomics — Posted on 2025-01-22
1687 Oxidative stress leads to Fur-mediated activation of ftnA in Escherichia coli independently of OxyR/SoxRS regulators
Matveeva, V. O.; Grebennikova, A. D.; Sakharov, D. I.; Fomin, V. V.; Manukhov, I. V.; Bazhenov, S. V.
10.1101/2025.01.22.634231 — molecular biology — Posted on 2025-01-22
1688 Functional interplay between condensin I and topoisomerase IIα in single-molecule DNA compaction
Tsubota, Y.; Shintomi, K.; Kinoshita, K.; Masahara-Negishi, Y.; Aizawa, Y.; Shima, M.; Hirano, T.; Nishiyama, T.
10.1101/2025.01.21.634015 — molecular biology — Posted on 2025-01-22
1693 Development of Severity Index for Oral Epithelial Dysplasia Using Fuzzy Group Decision Making Algorithm
NAWN, D.; Lahiri, P.; De, B.; Pal, M.; Paul, R. R.; Adhya, D. G.; Chakraborty, D.; Chatterjee, J.
10.1101/2025.01.20.633806 — cancer biology — Posted on 2025-01-22
1695 All-Optical Strategies to Minimize Photo-Bleaching in Reversibly Switchable Fluorescent Proteins
Marin-Aguilera, G.; Pennacchietti, F.; Volpato, A.; Papalini, A.; Kulkarni, A.; Bagheri, N.; Minet, G.; Widengren, J.; Testa, I.
10.1101/2025.01.20.633912 — biophysics — Posted on 2025-01-22
1699 Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice
Zhu, D.; Wu, J. Z.; Griffin, P. T.; Samuelson, B. A.; Sinclair, D. A.; Kane, A. E.
10.1101/2025.01.22.634160 — biochemistry — Posted on 2025-01-22
1701 Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis
Shimogawa, M.; Li, M.-H.; Park, G. S. H.; Ramirez, J.; Lee, H.; Watson, P.; Sharma, S.; Lin, Z.; Peng, C.; Christianson, D. W.; Eliezer, D.; Rhoades, E.; Petersson, E. J.
10.1101/2025.01.21.634178 — biochemistry — Posted on 2025-01-22
1703 Computationally designed stem-epitope mimetics elicit broadly reactive antibodies
Wehrle, S.; Scheck, A.; Reusch, L.; Matassoli, F.; Georgeon, S.; Castro, K. M.; Cramer, J.; Harshbarger, W.; Rosset, S.; Andrews, S. F.; Schon, K.; Bouzya, B.; Rouxel, R.; Blais, N.; Malito, E.; McDermott, A.; Krey, T.; Mallett, C. P.; Vassilev, V.; Angeletti, D.; Correia, B.
10.1101/2025.01.22.634229 — biochemistry — Posted on 2025-01-22
1706 An area-resolved phylogeography of bulbous barley (Hordeum bulbosum; Poaceae)
Blattner, F. R.; Pfanzelt, S.; Koch, C.; Himmelbach, A.; Sassone, A. B.; Abdulkarim, A.; Shuka, L.; Harpke, D.
10.1101/2025.01.20.633865 — evolutionary biology — Posted on 2025-01-22
1707 Population Genomics of Giant Mice from the Faroe Islands: Hybridization, Colonization, and a Novel Challenge to Identifying Genomic Targets of Selection
Payseur, B. A.; Jing, P.; Howell, E. K.; Frayer, M. E.; Jones, E. P.; Magnussen, E.; Jensen, J.-K.; Chan, Y. F.; Searle, J. B.
10.1101/2025.01.20.633586 — evolutionary biology — Posted on 2025-01-22
1709 Lower spatial turnover of rare fungal taxa dominantly shaped by stochastic processes in grassland soils
Zhang, B.; Zhou, S.; Xue, K.; Liu, W.; Chen, S.; Tang, L.; Li, L.; Du, J.; Hao, Y.; Cui, X.; Wang, Y.
10.1101/2025.01.20.633927 — ecology — Posted on 2025-01-22
1710 Diversity and seasonality of ectoparasite burden on two species of Madagascar fruit bat, Eidolon dupreanum and Rousettus madagascariensis
Andrianiaina, A. F.; Andry, S.; Kettenburg, G. F.; Ranaivoson, H. C.; Lacoste, V.; Dussart, P.; Heraud, J.-M.; Laverty, T. M.; Guth, S.; Young, K. I.; Andrianarimisa, A.; Brook, C. E.
10.1101/2025.01.20.633693 — ecology — Posted on 2025-01-22
1712 ca-circSCN8A promotes HPASMCs ferroptosis via LLPS initiated R-Loop
Li, M.; Hao, Y.; Song, X.; Liu, H.; Zhang, C.; Zhang, J.; Sun, H.; Zheng, X.; Zhang, L.; Yu, H.; Ma, C.; Zhao, X.; Zhu, D.
10.1101/2025.01.21.634205 — molecular biology — Posted on 2025-01-22
1714 The effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by Culex mosquitoes and pathogenesis in a vertebrate host
van Bree, J.; Visser, I.; Marshall, E. M.; Willemsen, W.; van de Waterbeemd, C.; Abma-Henkens, M.; van Oers, M. M.; Pijlman, G. P.; Rockx, B.; Fros, J. J.
10.1101/2025.01.22.634234 — microbiology — Posted on 2025-01-22
1715 Extracellular polymeric substance degradation shapes microbial community diversity
Pontrelli, S.; Bigovic Villi, K.; Sichert, A.; Trouillon, J.; Rutz, A.; Landry, Z.; Rudisser, S. H.; Stocker, R.; Sauer, U.
10.1101/2025.01.22.634264 — microbiology — Posted on 2025-01-22
1716 Type I partition-related proteins enhance conjugative transfer through transcriptional activation and oriT region binding
Kishida, K.; Kudo, K.; Kumagai, R.; Deng, W.; Stari, L.; Ogawa-Kishida, N.; Ohtsubo, Y.; Nagata, Y.; Tsuda, M.
10.1101/2025.01.22.634284 — microbiology — Posted on 2025-01-22
1717 Sulfoquinovose is differently degraded by the mouse and human gut microbiota and not metabolized by the host
Krasenbrink, J.; Hanson, B. T.; Weiss, A. S.; Borusak, S.; Tanabe, T. S.; Lang, M.; Aichinger, G.; Hausmann, B.; Berry, D.; Richter, A.; Marko, D.; Mussmann, M.; Schleheck, D.; Stecher, B.; Loy, A.
10.1101/2025.01.22.634256 — microbiology — Posted on 2025-01-22
1718 Role of the Nucleotide Excision Repair endonuclease XPF in the kinetoplastid parasite Trypanosoma brucei
Gomez-Linan, C.; Saez-Maldonado, M.; Ruiz-Perez, L. M.; Gonzalez-Pacanowska, D.; Vidal, A. E.
10.1101/2025.01.22.633349 — microbiology — Posted on 2025-01-22
1719 Degradation rather than disassembly of necrotic debris is essential to enhance recovery after acute liver injury
Schuermans, S.; Quanico, J.; Kestens, C.; Vandendriessche, S.; Slowikowski, E.; Crijns, M. L.; Portner, N.; Berghmans, N.; Baggerman, G.; Mattos, M. S.; Proost, P.; Marques, P. E.
10.1101/2025.01.20.633891 — immunology — Posted on 2025-01-22
1720 SwiftMHC: A High-Speed Attention Network for MHC-Bound Peptide Identification and 3D Modeling
Xue, L. C.; Baakman, C.; Crocioni, G.; Rademaker, D. T.; Aarts, Y. J. M.; Fruehbuss, D.
10.1101/2025.01.20.633893 — immunology — Posted on 2025-01-22
1721 STAT3 phosphorylation in the rheumatoid arthritis immunological synapse
Novak, H.; Capera, J.; Jainarayanan, A. K.; Mayya, V.; Zanin-Zhorov, A.; Valvo, S.; MacDonald, J.; Taylor, P. C.; Dustin, M. L.
10.1101/2025.01.20.633875 — immunology — Posted on 2025-01-22
1722 SLAMF6 enables efficient attachment, synapse formation, and killing of HIV-1-infected CD4+ T cells by virus-specific CD8+ T cells
Monel, B.; Lamothe-Molina, P. A.; Meyo, J.; McLean, A. P.; Quinones-Alvarado, R.; Laporte, M.; Boucau, J.; Walker, B. D.; Kavanagh, D. G.; Garcia-Beltran, W. F.; Pacheco, Y.
10.1101/2025.01.20.633914 — immunology — Posted on 2025-01-22
1723 CLASP1/2 REGULATE IMMUNE SYNAPSE MATURATION IN NATURAL KILLER CELLS
Pariani, A. P.; Huhn, V.; Rivabella-Maknis, T.; Alonso, V. L.; Almada, E.; Vena, R.; Favre, C.; Goldenring, J. R.; Kaverina, I.; Larocca, M. C.
10.1101/2025.01.20.633904 — immunology — Posted on 2025-01-22
1724 Large Animal Epilepsy Model Platform: Kainic Acid Porcine Model of Mesial Temporal Lobe Epilepsy
Mivalt, F.; Maltais, D.; Kim, I.; Kim, J.; Began, P.; Duque Lopez, A.; Krakorova, V.; Winter, B.; Gregg, N. M.; Montonye, D.; Gow, C.; Miller, K. J.; Van Gompel, J.; Leyde, K.; Kremen, V.; Worrell, G. A.
10.1101/2025.01.22.634312 — neuroscience — Posted on 2025-01-22
1726 Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion
Sudarsanam, S.; Guzman-Clavel, L.; Dar, N.; Ziak, J.; Shahid, N.; Jin, X. O.; Kolodkin, A. L.
10.1101/2025.01.22.634300 — neuroscience — Posted on 2025-01-22
1730 Adiponectin exerts sex-dependent effects on lipid, amino acid, and glucose metabolism during caloric restriction
Ikushima, Y. M.; Chen, K.-C.; Sulston, R. J.; Mattiucci, D.; Brain, E. J.; Fung Xin Zi, S. A.; Suchacki, K. J.; Thomas, B. J.; Lovdel, A.; Bennett, M.; Kobayashi, H.; Whitfield, P. D.; Takubo, K.; Baker, A. H.; Morton, N. M.; Semple, R. K.; Cawthorn, W. P.
10.1101/2025.01.20.633882 — physiology — Posted on 2025-01-22
1734 Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system
Nelson, C. B.; Wells, J. K.; Kesarwani, E.; Sobinoff, A. P.; Gao, J.; MacKenzie, K. L.; Poulos, R. C.; Nawaz, U.; Wang, X.; Ford, H. L.; Pickett, H. A.
10.1101/2025.01.19.633804 — cancer biology — Posted on 2025-01-22
1736 Integrative multi-layer workflow for quantitative analysis of post-translational modifications
Devesa, C. A.; Barrero-Rodriguez, R.; Laguillo Gomez, A.; Guerrero-Sanchez, V. M.; del Rio-Aleda, D.; Mena, D.; Jorge, I.; Nunez, E.; Calvo, E.; Lopez, J. A.; Marin-Vicente, C.; Martinez-Val, A.; Camafeita, E.; Ibanez, B.; Enriquez, J. A.; Martin-Ventura, J. L.; Rodriguez, J. M.; Vazquez, J.
10.1101/2025.01.20.633864 — bioinformatics — Posted on 2025-01-22
1737 A comprehensive quality control pipeline in human microbiome research for large population studies
Li, R.; A.M. Verlouw, J.; G. Boer, C.; Arp, P.; van Meurs, J.; G. Uitterlinden, A.; Kraaij, R.; Medina-Gomez, C.
10.1101/2025.01.20.633643 — bioinformatics — Posted on 2025-01-22
1739 Transcriptomic analysis of chronic chikungunya in the Reunionese CHIKGene cohort uncovers a shift in gene expression more than 10 years after infection
Gerardin, P.; Medina-Santos, R.; Le Clerc, S.; Bruneau, L.; Maillot, A.; Labib, T.; Rahmouni, M.; Spadoni, J.-L.; Meyniel, J.-P.; Cornet, C.; Lefebvre, C.; El Jahrani, N.; Savara, J.; Mathew, M. J.; Fontaine, C.; Payet, C.; Ah-You, N.; Chabert, C.; Mussard, C.; Porcherat, S.; Medjane, S.; Noirel, J.; Marimoutou, C.; Hocini, H.; Zagury, J.-F.
10.1101/2025.01.20.633311 — bioinformatics — Posted on 2025-01-22
1742 Risk Prediction of RNA Off-Targets of CRISPR Base Editors in Tissue-Specific Transcriptomes Using Language Models
Nakamae, K.; Suzuki, T.; Yonezawa, S.; Yamamoto, K.; Kakuzaki, T.; Ono, H.; Naito, Y.; Bono, H.
10.1101/2025.01.19.633823 — genomics — Posted on 2025-01-22
1744 Contribution of DNA breathing to physical interactions with transcription factors
Butt, W. A.; Lai, B.; Chiu, T.-P.; Bhattarai, M.; Qian, S.; Bishop, A. R.; Duan, J.; Alexandrov, B. S.; Rohs, R.; He, X.
10.1101/2025.01.20.633840 — genetics — Posted on 2025-01-22
1747 Distinct Genetic Populations and Resistance Backgrounds of the Malaria Vector Anopheles funestus in Tanzania
Odero, J. O.; Nambunga, I. H.; Bwanary, H.; Mkandawile, G.; Paliga, J. M.; Mapua, S. A.; Mwinyi, S. H.; Ngowo, H. S.; Govella, N. J.; Kaindoa, E. W.; Tripet, F.; Hernandez-Koutoucheva, A.; Ferguson, H. M.; Clarkson, C. S.; Miles, A.; Weetman, D.; Baldini, F.; Okumu, F. O.; Dennis, T. P. W.
10.1101/2025.01.21.634154 — genetics — Posted on 2025-01-22
1752 Delayed copulation and mating in the malaria vector Anopheles funestus compared to Anopheles arabiensis
Hape, E. E.; Ngonyani, A. T.; Mabula, D. M.; Nkya, J. D.; Thomas, C. A.; Omari, M. J.; Siria, D. J.; Ngowo, H. S.; Koekemoer, L. L.; Okumu, F. O.
10.1101/2025.01.20.633855 — ecology — Posted on 2025-01-22
1753 Spatial pattern of serology against Borrelia and tick-borne encephalitis virus in roe deer (Capreolus capreolus), Northern France, 2019-2022
Metras, R.; Bastien, M.; Ollivier, V.; Poisson, A.; Combes, B.; Gonzalez, G.; Helle, T.; Migne, C. V.; Suhanda, I. E.; Kim, Y.; Verheyden, H.; Boulinier, T.
10.1101/2025.01.20.633885 — ecology — Posted on 2025-01-22
1754 Mechanical signalling through collagen I regulates cholangiocyte specification and tubulogenesis during liver development
Thelwall, I. G.; Morell, C. M.; Dziedzicka, D.; Cabriales, L.; Hodgson, A.; Roos, F. J. M.; Elfari, L.; Vallier, L.; Chalut, K. J.
10.1101/2025.01.22.633528 — developmental biology — Posted on 2025-01-22
1757 LIN28-mediated gene regulatory loops synchronize developmental transitions throughout organogenesis
Thevarajan, I.; Osuna, M. F.; Lewey, S. F.; Sauceda, E.; Briseno, S.; Griffin, C.; Kim, B.; Rowe, R. G.; da Rocha, E. L.; Osborne, J. K.
10.1101/2025.01.22.634324 — developmental biology — Posted on 2025-01-22
1758 Selection of pre-leukemic hematopoietic stem cells driven by distinct extracellular matrix molecules
Jassinskaja, M.; Bode, D.; Gonka, M.; Roumeliotis, T. I.; Hogg, A. J.; Rubio Lara, J. A.; Bennett, E.; Milek, J.; Theeuwes, B.; Vijayabaskar, M. S.; Cabrera Cosme, L.; Che, J. L. C.; MacDonald, S.; Ahmed, S.; Hall, B. A.; Vasey, G.; Kooi, H.; Belmonte, M.; Shepherd, M. S.; Brackenbury, W. J.; Kucinski, I.; Yamazaki, S.; Holding, A. N.; Cull, A. H.; Wilson, N. K.; Gottgens, B.; Chaudhary, J. S.; Kent, D. G.
10.1101/2025.01.20.633881 — cell biology — Posted on 2025-01-22
1760 Scube2 primes Dispatched and ADAM10-mediated Shh release by recruiting HDL acceptors to the plasma membrane
Puschmann, J.; Steffes, G.; Froese, J.; Manikowski, D.; Ehring, K.; Wittke, J.; Garbers, C.; Wegner, S. V.; Grobe, K.
10.1101/2025.01.20.633902 — cell biology — Posted on 2025-01-22
1761 CAR T cell engineering impacts antigen-independent activation and co-inhibition
Stuecheli, S.; Schultheiss, C.; Schmidt-Barbo, P.; Zingg, A.; Franz, N.; Adamo, S.; Fischer, C.; Laubli, H.; Binder, M.
10.1101/2025.01.20.631849 — immunology — Posted on 2025-01-22
1762 Immune and Mutational Profile of Gene-Edited Low-Immunogenic Human Primary Cholangiocyte Organoids
Petrus-Reurer, S.; Baez-Ortega, A.; Lei, W.; Kumaran, G.; Williamson, J.; Jones, J.; Trajkovski, D.; Lawson, A. R.; Mahbubani, K. T.; Brodie, C.; Lehner, P. J.; Bottomley, M. J.; Martincorena, I.; Saeb-Parsy, K.
10.1101/2025.01.20.628680 — immunology — Posted on 2025-01-22
1763 Rubisco is slow across the tree of life
de Pins, B.; Malbranke, C.; Jablonska, J.; Shmuel, A.; Sharon, I.; Bitbol, A.-F.; Mueller-Cajar, O.; Noor, E.; Milo, R.
10.1101/2025.01.19.633714 — systems biology — Posted on 2025-01-22
1764 Molecular mechanisms underlying the early steps of floral initiation in seasonal flowering genotypes of cultivated strawberry
Ziegler, F. M. R.; Gaston, A.; Guy, K.; Devers, M.; Krueger, E.; Brauksiepe, B.; Eimert, K.; Osorio, S.; Denoyes, B.; Usadel, B.
10.1101/2025.01.20.633581 — plant biology — Posted on 2025-01-22
1765 Light induces Phytochrome B SUMOylation to recruit the immune regulator NPR1 in nuclear condensates to control immunity in plants
Ghosh, S.; Ghosh, S.; Mansi, M.; Long, X.; Clark, L.; Srivastava, A.; Kakkunath, S.; Orosa-Puente, B.; Bailey, M.; Bhagat, P. K.; Gough, C.; Zhang, C.; de Lucas, M.; Sadanandom, A.
10.1101/2025.01.19.633791 — plant biology — Posted on 2025-01-22
1770 RAS-PI3K Pathway in CAFs Shapes Physicochemical Properties of Tumor ECM and restrains Tumor progression
Cuesta, C.; Alcon-Perez, M.; Zheng, J.; Procel, N.; Cota, R. R.; Fennema, D.; Rosell, A.; Meson, D. L.; Martinez-Castedo, B.; Arafat, Y.; Sanz-Fraile, H.; Rajeeve, V.; Alonso, D.; Hynds, R. E.; Swanton, C.; Alcaraz, J.; Cutillas, P.; Reyes-Aldasoro, C. C.; Wang, H.; Castellano, E.
10.1101/2025.01.20.633776 — cancer biology — Posted on 2025-01-22
1771 Artificial Intelligence Apps for Medical Image Analysis using pyCERR and Cancer Genomics Cloud
Apte, A.; LoCastro, E.; Iyer, A.; Elguindi, S.; Jiang, J.; Oh, J. H.; Veeraraghavan, H.; Dave, A.; Deasy, J. O.
10.1101/2025.01.19.633756 — bioinformatics — Posted on 2025-01-22
1779 A revision of the Neotropical Costaceae: results from sixty years of taxonomic struggle
Maas, P. J. M.; Maas-van de Kamer, H.; Andre, T.; Skinner, D.; Valderrama, E.; Specht, C. D.
10.1101/2025.01.15.633188 — evolutionary biology — Posted on 2025-01-22
1780 Characterizing venom resistance in Monodelphis domestica yields new insights into mammalian blood physiology
Holding, M. L.; Disharoon, D.; Haynes, L. M.; Paruchuri, B. C.; Golden, K.; Shavit, J.; Desch, K.; Ginsburg, D.; Sen Gupta, A.; Cruz, Y. P.; Drabeck, D.
10.1101/2025.01.21.634112 — evolutionary biology — Posted on 2025-01-22
1782 Virus infection significantly decreases insect fitness: a meta-analysis
Cesar, C. S.; Miranda, V. H.; Silveira, E. R.; de Oliveira, T. A.; Cogni, R.
10.1101/2025.01.19.633787 — ecology — Posted on 2025-01-22
1784 The metabolic enzyme GYS1 condenses with NONO/p54nrb in the nucleus to spatiotemporally regulate glycogenesis and myogenic differentiation
Peng, S.; Li, C.; Wang, Y.; Yi, Y.; Chen, X.; Yin, Y.; Yang, F.; Chen, F.; Ouyang, Y.; Xu, H.; Chen, B.; Shi, H.; Li, Q.; Zhao, Y.; Feng, L.; Gan, Z.; Xie, x.
10.1101/2025.01.19.633807 — cell biology — Posted on 2025-01-22
1786 Meta all the way down: An overview of neuroimaging meta-analyses
Oudyk, K. M.; Dockes, J.; Peraza, J. A.; Kent, J.; Torabi, M.; Wang, M.; McPherson, B. C.; Mirhakimi, N.; de la Vega, A.; Laird, A.; Poline, J.-B.
10.1101/2025.01.21.634094 — neuroscience — Posted on 2025-01-22
1788 Inhibiting EZH2 Alleviates Osteoarthritis and Pain in an Experimental Murine Model Through Modulating Synovial and Macrophage Inflammation, Axon Guidance, and Osteoclastogenesis
Brochard, S.; Vanlaeys, A.; Taieb, M.; Richard, I.; Aury-Landas, J.; Bernay, B.; Pontin, J.; Seillier, C.; Bon, N.; Picart, B.; Pecqueur, C.; Toutirais, O.; Vinatier, C.; Guicheux, J.; Maubert, E.; Agin, V.; Boumediene, K.; Bauge, C.
10.1101/2025.01.19.633762 — physiology — Posted on 2025-01-22
1792 Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma
Li, K.; Tolman, N.; V. Segre, A.; Stuart, K.; Zeleznik, O. A.; Vallabh, N. A.; Hu, K.; Zebardast, N.; Hanyuda, A.; Raita, Y.; Montgomery, C.; Zhang, C.; Hysi, P. G.; Do, R.; Khawaja, A.; Wiggs, J.; Kang, J.; John, S.; Pasquale, L.
10.1101/2025.01.18.633745 — genomics — Posted on 2025-01-22
1793 Fate of a supergene in the shift from diploidy to polyploidy
Mora Carrera, E.; Yousefi, N.; Potente, G.; Stubbs, R. L.; Keller, B.; Leveille-Bourret, E.; Stefan, G.; Celep, F.; Giorgi, T.; Conti, E.
10.1101/2025.01.18.633704 — evolutionary biology — Posted on 2025-01-22
1796 A novel quinone biosynthetic pathway illuminates the evolution of aerobic metabolism
Elling, F. J.; Pierrel, F.; Chobert, S.-C.; Abby, S. S.; Evans, T. W.; Reveillard, A.; Pelosi, L.; Schnoebelen, J.; Hemingway, J. D.; Boumendjel, A.; Becker, K. W.; Blom, P.; Cordes, J.; Nathan, V.; Baymann, F.; Lucker, S.; Spieck, E.; Leadbetter, J. R.; Hinrichs, K.-U.; Summons, R. E.; Pearson, A.
10.1101/2024.07.27.605408 — microbiology — Posted on 2025-01-22
1798 SCAN-ACT: Adoptive T Cell Therapy Target Discovery Through Single-Cell Transcriptomics
Testa, S.; Pal, A.; Subramanian, A.; Varma, S.; Tang, J. P.; Graham, D.; Arfan, S.; Pan, M.; Bui, N. Q.; Ganjoo, K. N.; Dry, S.; Huang, P. H.; van de Rijn, M.; Jiang, W.; Kalbasi, A.; Moding, E. J.
10.1101/2025.01.18.633736 — cancer biology — Posted on 2025-01-22
1800 A bright synthetic near-infrared luciferin enhances the capabilities of deep-tissue bioluminescence imaging using firefly luciferases
Saito-Moriya, R.; Iwano, S.; Kitada, N.; Yamasaki, N.; Kamiya, G.; Ogo, K.; Sugiyama, T.; Chuluun-Erdene, A.; Isagawa, T.; Obata, R.; Ijuin, R.; Abe, H.; Kashiwakura, Y.; Mabuchi, Y.; Takahashi, M.; Yamamoto, Y.; Sawaki, D.; Sato, T.; Sato, S.; Nishikii, H.; Yoshimura, K.; Hioki, H.; Ohmori, T.; Nakashiba, T.; Hirano, T.; Aoyama, H.; Takeda, N.; Miyawaki, A.; Maki, S.; Kuchimaru, T.
10.1101/2025.01.20.633992 — cancer biology — Posted on 2025-01-22
1801 Multifunctional bending magnet beamline with a capillary optic for X-ray fluorescence studies of metals in tissue sections
Roter, B.; Crawford, A. M.; Jin, Q.; Glowacki, A. T.; Lai, B.; Marin, F. S.; Maxey, E. R.; Shi, X.; Culotta, V. C.; Wildeman, A. S.; Patel, N. K.; O'Halloran, T. V.; Jacobsen, C.
10.1101/2025.01.18.633695 — biophysics — Posted on 2025-01-22
1803 Mammal niches are not conserved over continental scales
Goldstein, B. R.; Pacifici, K.; Jensen, A. J.; Reich, B. J.; Cove, M. V.; McShea, W. J.; Rooney, B.; Kierepka, E. M.; Roberts, R. A.; Kays, R.
10.1101/2025.01.17.633640 — ecology — Posted on 2025-01-22
1806 Oncogenic Stress is a Novel Immunogenic Signal Driven by the Unfolded Protein Response and Detected by Neutrophils
Debiesse, A.; Moudombi, L.; Voissiere, A.; Lefevre, L.; Malfroy, M.; Moskalevska, I.; Pereira Abrantes, M.; Vanacker, H.; Hubert, M.; Pommier, R.; Assaf, C.; Jacquet, E.; Laurent, M.; Belluco, S.; Goutagny, N.; Petrilli, V.; Cherfils-Vicini, J.; Caux, C.; Bendriss-Vermare, N.; Michallet, M.-C.
10.1101/2025.01.17.633444 — immunology — Posted on 2025-01-22
1808 CYP722A1-driven 16-hydroxylation of carlactonoic acid regulates the floral transition in Arabidopsis
Kuno, M.; Miyamoto, A.; Takano, H.; Homma, M.; Shiotani, N.; Uchida, K.; Takikawa, H.; Nakajima, M.; Mizutani, M.; Wakabayashi, T.; Sugimoto, Y.
10.1101/2025.01.17.633504 — plant biology — Posted on 2025-01-22
1809 Decoding cellular transcriptional regulatory networks governing wheat inflorescence development
Liu, X.; Lin, X.; Kang, J.; Long, K. A.; Yue, J.; Chen, C.; Wang, D.; Lister, A.; Macaulay, l. C.; Liu, X.; Uauy, C.; Xiao, J.
10.1101/2025.01.18.633750 — plant biology — Posted on 2025-01-22
1811 Enantioselective Protein Affinity Selection Mass Spectrometry (EAS-MS)
Wang, X.; Sun, J.; Ahmad, S.; Yang, D.; Li, F.; Chan, U. H.; Zeng, H.; Simoben, C. V.; Houliston, S.; Dong, A.; Bolotokova, A.; Gibson, E.; Kutera, M.; Ghiabi, P.; Kondratov, I.; Matviyuk, T.; Chuprina, A.; Mavridi, D.; Lenz, C.; Joerger, A. C.; Brown, B. D.; Heath, R. B.; Yue, W.; Robbie, L. K.; Beyett, T. S.; Muller, S.; Knapp, S.; Harding, R. J.; Schapira, M.; Brown, P. J.; Santhakumar, V.; Ackloo, S.; Arrowsmith, C. H.; Edwards, A.; Peng, H.; Halabelian, L.
10.1101/2025.01.17.633682 — pharmacology and toxicology — Posted on 2025-01-22
1813 Neoplastic immune mimicry is a generalizable phenomenon in breast cancer and epithelial CD69 enables early tumor progression
Berens, E. B.; Khou, S.; Huang, E.; Hoffman, A.; Johnson, B.; Kirchberger, N.; Sivagnanam, S.; Calistri, N. L.; Derrick, D.; Liby, T. A.; McLean, I. C.; Alanizi, A. A.; Ozmen, F.; Ozmen, T. Y.; Mills, G. B.; Hwang, E. S.; Schedin, P. J.; Gonzalez, H.; Werb, Z.; Heiser, L. M.; Coussens, L. M.
10.1101/2025.01.17.633673 — cancer biology — Posted on 2025-01-22
1814 Isolation and Bioassay of Linear Veraguamides from a Marine Cyanobacterium (Okeania sp.)
Parker, S.-A. J.; Hough, A.; Lax, N.; Wright, T.; Faruk, A.; Fofie, C. K.; Simcik, R.; Cavanaugh, J. E.; Kolber, B. J.; Tidgewell, K. J.
10.1101/2025.01.18.633713 — cancer biology — Posted on 2025-01-22
1815 Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis
Durfee, C.; Bergstrom, E. N.; Diaz-Gay, M.; Zhou, Y.; Temiz, N. A.; Ibrahim, M. A.; Nandi, S. P.; Wang, Y.; Liu, X.; Steele, C. D.; Proehl, J.; Vogel, R. I.; Argyris, P. P.; Alexandrov, L. B.; Harris, R.
10.1101/2025.01.18.633716 — cancer biology — Posted on 2025-01-22
1816 Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities
Zhao, H.; Park, Y. M.; Zheng, Y.; Mao, Q.; Collet, C. A.; Hu, B.; Zhou, T.; Lin, L.; Wong, S.; Pan, Y.; Monreal, A. V.; Sinha, U. K.; Sedghizadeh, P. P.; Soragni, A.; Lin, D.-C.
10.1101/2025.01.18.631624 — cancer biology — Posted on 2025-01-22
1817 Enhanced AkaLuc Bioluminescence Imaging for Longitudinal Intravital Monitoring of Minimal Residual Disease in a Murine Model of Triple-negative Breast Cancer
Steinbauer, S.; Cowles, J. D.; Sabbaghi, M. A.; Poppelaars, M.; Hussain, A.; Wagesreither, M.; Laimer-Gruber, D.; Tovari, J.; Szakacs, G.; Csiszar, A.
10.1101/2025.01.18.633734 — cancer biology — Posted on 2025-01-22
1818 Markovian State Models uncover Casein Kinase 1 dynamics that govern circadian period
Gravina Ricci, C.; Philpott, J. M.; Torgrimson, M. R.; Freeberg, A. M.; Narasimamurthy,, R.; Pecora de Barros, E.; Amaro, R. E.; Virshup, D. M.; McCammon, J. A.; Partch, C. L.
10.1101/2025.01.17.633651 — biophysics — Posted on 2025-01-22
1820 Tying the Knot: In Silico Design of Foldable Lasso Peptides
Nguyen, J. D. M.; da Hora, G. C. A.; Mifflin, M. C.; Roberts, A. G.; Swanson, J. M. J.
10.1101/2025.01.17.633674 — biophysics — Posted on 2025-01-22
1823 RecAlign: A* recombination-aware sequence to graph mapping
Bonizzoni, P.; Monti, D. C.; Della Vedova, G.; Riccardi, B.; Rizzi, R.; Siren, J.
10.1101/2025.01.18.633308 — bioinformatics — Posted on 2025-01-22
1827 Breaking the Phalanx: Overcoming Bacterial Drug Resistance with Quorum Sensing Inhibitors that Enhance Therapeutic Activity of Antibiotics
Beasley, J.-M.; Dorjsuren, D.; Jain, S.; Rath, M.; Scheufen Tieghi, R.; Tropsha, A.; Simeonov, A.; Zakharov, A. V.; Muratov, E.
10.1101/2025.01.17.633658 — bioinformatics — Posted on 2025-01-22
1830 Low level contamination confounds population genomic analysis
Ward, A.; Scopel, E. F. C.; Shuman, B.; Momany, M.; Bensasson, D.
10.1101/2025.01.17.633387 — genomics — Posted on 2025-01-22
1831 Epigenetic mechanisms regulating CD8+ T cell senescence in aging humans
Turano, P. S.; Dewald, H. K.; Akbulut, E.; Vasilopoulos, T.; Fitzgerald-Bocarsly, P.; Herbig, U.; Martinez Zamudio, R. I.
10.1101/2025.01.17.633634 — genomics — Posted on 2025-01-22
1832 Pervasive and programmed nucleosome distortion patterns on single mammalian chromatin fibers
Yang, M. G.; Richter, H. J.; Wang, S.; McNally, C. P.; Harris, N.; Dhillon, S.; Maresca, M.; de Wit, E.; Willenbring, H.; Maher, J.; Goodarzi, H.; Ramani, V.
10.1101/2025.01.17.633622 — genomics — Posted on 2025-01-22
1833 Mouse Single-Cell Long-Read Splicing Atlas by Ouro-Seq
An, H.; Choi, S. Y.; Yi, J.; Lim, C.; Shin, S.-I.; Oh, S.; Lee, R. H.; Park, J.
10.1101/2025.01.17.633678 — genomics — Posted on 2025-01-22
1834 Single-cell decoding of human islet cell type-specific alterations in type 2 diabetes reveals converging genetic- and state-driven β-cell gene expression defects
Bandesh, K.; Motakis, E.; Nargund, S.; Kursawe, R.; Selvam, V.; Bhuiyan, R.; Eryilmaz, G. N.; Krishnan, S. N.; Spracklen, C. N.; Ucar, D.; Stitzel, M. L.
10.1101/2025.01.17.633590 — genomics — Posted on 2025-01-22
1843 Bayesian phylodynamic inference of population dynamics with dormancy
Cappello, L.; Lo, W. T. J.; Zhang, J. Z.; Xu, P.; Barrow, D.; Chopra, I.; Clark, A. G.; Wells, M. T.; Kim, J.
10.1101/2025.01.19.633741 — evolutionary biology — Posted on 2025-01-22
1845 The capability of plant-bacteria consortia to reduce the genotoxicity of unsymmetrical dimethylhydrazine in the environment
Novoyatlova, U.; Kessenikh, A.; Kononenko, N.; Baranova, E.; Chalkin, S.; Bazhenov, S. V.; Manukhov, I. V.
10.1101/2025.01.17.633569 — ecology — Posted on 2025-01-22
1847 First occurrence of Ranavirus in Scandinavian peninsula
Thumsova, B.; Chondrelli, N.; Valdes, A. E.; Eghbal, R.; Hoglund, J.; Laurila, A.; Bosch, J.; Cortazar- Chinarro, M.
10.1101/2025.01.17.633642 — ecology — Posted on 2025-01-22
1849 Notes on the diet and size of Cassiopea
Muffett, K. M.; Mammone, M.; Morejon-Arrojo, R.; Toso, A.; Fumarola, L. M.; Klovrza, A.; Cardona, V.; Geson, S. M.; Rowe, C.; Bellantuono, A.; Migietta, M. P.; Collin, R.
10.1101/2025.01.18.633672 — ecology — Posted on 2025-01-22
1851 Macrophages restrict tumor permissiveness to immune infiltration by controlling local collagen topography through a Tcf4-Collagen3 fibrotic axis
Fusilier, Z.; Simon, F.; Calvente, I.; Crestey, L.; Clement, A.; Mathieu, M.; Jean-Marie, R.; Piastra-Facon, F.; George Clement, J.; Lumineau, E.; Tonani, M.; Manriquez, V.; Lacerda, L.; de Villemagne, P.; Piaggio, E.; Semetey, V.; Coscoy, S.; Martini, E.; Scita, G.; Gelly, J.-C.; Ivaska, J.; Isambert, H.; Goudot, C.; Pierobon, P.; Lennon-Dumenil, A.-M.; Moreau, H. D.
10.1101/2025.01.17.633527 — immunology — Posted on 2025-01-22
1852 Super-omics and PCAS reveal rheumatoid arthritis as a tumor-like disease
Xiao, L.; Aishan, N.; Ju, S.; Zhao, F.; Ouyang, X.; Chen, D.; Chen, W.; Xie, J.; Zhu, D.; Zhang, J.; Sun, L.; Li, Y.; Zhou, D.; Hu, Q.; Wu, J.; Meng, Q.; Zhou, J.; Xu, D.; Yu, J.; Liang, J.; Cai, Y.; Zhang, M.; He, Y.; Sun, Z.; Wang, L.; Lin, J.; Ji, F.
10.1101/2025.01.17.633562 — immunology — Posted on 2025-01-22
1854 Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring
Jimena, B.; Kazimierczyk, D.; Kazimierczyk, S.; Moya, H. A.; Shin, E.; Li, L.; Korgaonkar, P.; Porter, C.; Seed, B.; Cherayil, B. J.; Jain, N.
10.1101/2025.01.17.633596 — immunology — Posted on 2025-01-22
1855 Preserved suppressive function despite loss of Foxp3: insights into the identity of regulatory T cells
Luckerbauer, B.; Villarino, A. V.; Laurence, A.; Hirahara, K.; Sciume, G.; Mikami, Y.; Shih, H.-Y.; Sun, H.-W.; Tosevska, A.; Brinkmann, M.; Brooks, S.; Scheffel, J.; Meylan, F.; Afzali, B.; Bonelli, M.
10.1101/2025.01.17.633544 — immunology — Posted on 2025-01-22
1858 Interrupting T cell memory ameliorates exaggerated metabolic response to weight cycling
Garcia, J. N.; Cottam, M. A.; Rodriguez, A. S.; Hussein Agha, A. F.; Winn, N. C.; Hasty, A. H.
10.1101/2025.01.17.633599 — physiology — Posted on 2025-01-22
1860 STExplorer: Navigating the Micro-Geography of Spatial Omics Data
Zormpas, E.; Vlachogiannis, N. I.; Resteu, A.; Unsworth, A.; Tual-Chalot, S.; Dorgau, B.; Queen, R.; Lako, M.; Tiniakos, D.; Comber, A.; Anstee, Q. M.; Giakountis, A.; Cockell, S. J.
10.1101/2025.01.17.633539 — bioinformatics — Posted on 2025-01-22
1861 In vivo deletion of a GWAS-identified Myb distal enhancer acts on Myb expression, globin switching, and clinical erythroid parameters in beta-thalassemia
Deleuze, V.; Stephen, T.; Salma, M.; Orfeo, C.; Jorna, R.; Maas, A.; Barroca, V.; Arcangeli, M.-L.; Andrieu-Soler, C.; Grosveld, F.; Soler, E.
10.1101/2025.01.17.633540 — genetics — Posted on 2025-01-22
1864 Follicular mural granulosa cells stockpile glycogen to fuel corpus luteum pre-vascularization
Liao, J.; Liu, Q.; Liu, C.; Liu, G.; Li, X.; Wang, X.; Wang, Y.; Liu, R.; Wu, H.; Shi, H.; Zhao, Y.; Ke, W.; Ran, Z.; Wu, Z.; Tan, B.; Wang, C.; Jiang, X.; Wang, Q.; Xie, Q.; Liu, G.; He, C.
10.1101/2025.01.22.634063 — developmental biology — Posted on 2025-01-22
1865 Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development
Zhao, J.; Bruche, S.; Lekkos, K.; Carr, C.; Vieira, J. M.; Parnavelas, J.; Andrews, W. D.; Mommersteeg, M.
10.1101/2025.01.22.634222 — developmental biology — Posted on 2025-01-22
1866 The Binary Cellular Biology of Human Growth I Quantifying the Creation and Growth of the Body and its Parts
Chodrow, P.; Su, J.; Lee, D.; He, N.; De Man, R.; Tiwari, A.; Mannherz, W.; Citi, L.; Gupta, R.; Gu, Z.; Cantonwine, D. E.; McElrath, T. F.; Tiemeier, H.; Michaelson, J. S.
10.1101/2025.01.22.634248 — developmental biology — Posted on 2025-01-22
1867 Generation of a Nr2f2-driven inducible Cre mouse to target interstitial cells in the reproductive system
Brown, P. R.; Estermann, M. A.; Gruzdev, A.; Scott, G. J.; Hagler, T. B.; Ray, M. K.; Yao, H. H.-C.
10.1101/2025.01.22.634276 — developmental biology — Posted on 2025-01-22
1868 Defining epithelial stem cell heterogeneity through undulating structures of the skin and oral mucosa
Ishikawa, M.; Ngo, Y. X.; Nishikawa, I.; Kato, H.; Maeda, R.; Mizuno, R.; Mizuno, J.; Izumi, K.; Yanagisawa, H.; Sada, A.
10.1101/2025.01.21.634195 — developmental biology — Posted on 2025-01-22
1869 A General Mechanism for Initiating the General Stress Response in Bacteria
Baral, R.; Ho, K.; Kumar, R. P.; Hopkins, J. B.; Watkins, M. B.; LaRussa, S.; Caban-Penix, S.; Calderone, L. A.; Bradshaw, N.
10.1101/2024.02.16.580724 — microbiology — Posted on 2025-01-22
1870 Proximity labeling of the Tau repeat domain enriches RNA-binding proteins that are altered in Alzheimer's disease and related tauopathies
Shapley, S. M.; Shantaraman, A.; Kearney, M. A.; Dammer, E. B.; Duong, D. M.; Bowen, C. A.; Bagchi, P.; Guo, Q.; Rangaraju, S.; Seyfried, N. T.
10.1101/2025.01.22.633945 — neuroscience — Posted on 2025-01-22
1872 Identifying mood instability and circadian rest-activity patterns using digital remote monitoring and actigraphy in participants at risk for bipolar disorder
Panchal, P.; Nelissen, N.; McGowan, N.; Atkinson, L.; Saunders, K.; Harrison, P.; Rushworth, M. F.; Draschkow, D.; Geddes, J.; Nobre, A. C.; Harmer, C.
10.1101/2025.01.20.633946 — neuroscience — Posted on 2025-01-22
1873 Anxiety-associated behaviors following ablation of Miro1 from cortical excitatory neurons
Myers, A. K.; Golden, J. A.; Sakheim, M.; Rivell, C.; Fengler, C.; Jarrahy, L.; Shin, R.; Case, M.; Chapman, C.; Basel, L.; Springer, S.; Kern, N.; Gidicsin, J.; Cho, G.; Kim, S.; Tighiouart, M.
10.1101/2025.01.22.634105 — neuroscience — Posted on 2025-01-22
1874 Fos expression in the periaqueductal gray, but not the ventromedial hypothalamus, is correlated with psychosocial stress-induced cocaine-seeking behavior in rats
Hinds, N. M.; Wojtas, I. D.; Pulley, D. M.; McDonald, S. J.; Spencer, C. D.; Sudarikov, M.; Hubbard, N. E.; Kulick-Soper, C. M.; de Guzman, S.; Hayden, S.; Debski, J. J.; Patel, B.; Fox, D. P.; Manvich, D. F.
10.1101/2025.01.22.634146 — neuroscience — Posted on 2025-01-22
1878 Disease exacerbation by fibroblast inclusion in Duchenne Muscular Dystrophy MYOrganoids reveals limitations of microdystrophin therapeutic efficacy
Palmieri, L.; Pili, L.; Jaber, A.; Vu Hong, A.; Marcello, M.; El Khoury, R.; Brochier, G.; Bigot, A.; Israeli, D.; Richard, I.; Albini, S.
10.1101/2023.07.26.550063 — bioengineering — Posted on 2025-01-22
1882 A field-focused systems approach reveals mRNA covalent modifications linked to sorghum growth and development under drought stress
Yu, L.; Melandri, G.; Dittrich, A. C.; Calleja, S.; Palos, K.; Srinivasan, A.; Brewer, E. K.; Henderson, R.; Garcia, C. D.; Zhang, X.; Rozzi, B.; Eveland, A.; Schroeder, S. J.; Stern, D.; Skirycz, A.; Lyons, E.; Arnold, E. A.; Gregory, B. D.; Nelson, A. D. L.; Pauli, D.
10.1101/2025.01.17.633510 — plant biology — Posted on 2025-01-22
1885 Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling
Le Gac, B.; Tournissac, M.; Belzic, E.; Picaud, S.; Dusart, I.; Soula, H.; Li, D.; Charpak, S.; Cauli, B.
10.1101/2024.03.27.586974 — neuroscience — Posted on 2025-01-22
1887 Multi-scale structure of chromatin condensates rationalizes phase separation and material properties
Zhou, H.; Huertas, J.; Maristany, M. J.; Russell, K.; Hwang, J. H.; Yao, R.; Hutchings, J.; Shiozaki, M.; Zhao, X.; Doolittle, L. K.; Gibson, B. A.; Riggi, M.; Rene Espinosa, J.; Yu, Z.; Villa, E.; Collepardo-Guevara, R.; Rosen, M. K.
10.1101/2025.01.17.633609 — biophysics — Posted on 2025-01-22
1890 Measuring the Strength of Spatial Sorting
Goel, N.; Comerford, M. S.; Bernat, A.; Egan, S. P.; Juenger, T. E.; Keitt, T. H.
10.1101/2025.01.17.633577 — evolutionary biology — Posted on 2025-01-22
1892 Reduced levels of synaptic vesicle protein 2A in the extracellular vesicles and brain of Alzheimer's disease- associations with Aβ, tau and synaptophysin
Nussbaumer, J.; Barve, A.; Zufferey, V.; Espourteille, J.; Kirabali, T.; Konietzko, U.; Razansky, D.; Rominger, A.; Nordberg, A.; Buee, L.; Colin, M.; Nitsch, R. M.; Hock, C.; Richetin, K.; Ni, R.
10.1101/2025.01.21.634009 — neuroscience — Posted on 2025-01-22
1893 PI3K regulates TAZ/YAP and mTORC1 axes that can be synergistically targeted
Garcia, K. C.; Khan, A. A.; Ghosh, K.; Sinha, S.; Scalora, N.; DeWane, G.; Fullenkamp, C.; Merritt, N.; Drebot, Y.; Yu, S.; Leidinger, M.; Henry, M. D.; Breheny, P.; Chimenti, M. S.; Tanas, M. R.
10.1101/2025.01.21.634138 — cancer biology — Posted on 2025-01-22
1895 Comparative evaluation of computational methods for reconstruction of human viral genomes
Sousa, M. J. P.; Toppinen, M.; Pyöriä, L.; Hedman, K.; Sajantila, A.; Perdomo, M. F.; Pratas, D.
10.1101/2025.01.17.633368 — bioinformatics — Posted on 2025-01-22
1896 EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis
Wang, L.; Yang, X.; Zhao, S.; Zheng, P.; Wen, W.; Xu, K.; Cheng, X.; Li, Q.; Khanshour, A. M.; Koike, Y.; Liu, J.; Fan, X.; Otomo, N.; Chen, Z.; Li, Y.; Li, L.; Xie, H.; Zhu, P.; Li, X.; Niu, Y.; Wang, S.; Liu, S.; Yuan, S.; Terao, C.; Li, Z.; Chen, S.; Zhao, X.; Liu, P.; Posey, J. E.; Wu, Z.; Qiu, G.; Ikegawa, S.; Lupski, J.; Rios, J. J.; Wise, C. A.; Zhang, J.; Zhao, C.; Wu, N.
10.1101/2024.03.04.583361 — genetics — Posted on 2025-01-22
1897 Autism-Associated Genes and Neighboring lncRNAs Converge on Key Gene Regulatory Networks
Andersen, R.; Talukdar, M.; Sakamoto, T.; Song, J. H.; Qian, X.; Lee, S.; Delgado, R. N.; Zhao, S.; Eichfeld, G.; Harms, J.; Walsh, C. A.
10.1101/2025.01.20.634000 — genetics — Posted on 2025-01-22
1898 Genomic stability in the Galapagos Scalesia adaptive radiation: Consistent transposable element accumulation despite hybridization and ecological niche shifts
Cerca, J.; Jaramillo Diaz, P.; Goubert, C.; Yang, H.; Bieke, V. C.; Fernandez-Mazuecos, M.; Vargas, P.; Schley, R. J.; Li, S.; Guevara-Andino, J. E.; Petersen, B.; Petersen, G.; Sinha, N.; Nielsen, L. R.; Leebens-Mack, J.; Rivas-Torres, G.; Rieseberg, L. H.; Martin, M.
10.1101/2024.09.30.614436 — evolutionary biology — Posted on 2025-01-22
1900 Independent and repeated acquisition of endosymbiotic bacteria across the diversification of feather lice
Soto-Patino, J.; Walden, K. K. O.; Dona, J.; D'Alessio, L. M.; Bush, S. E.; Clayton, D. H.; Dale, C.; Johnson, K. P.
10.1101/2025.01.17.633592 — evolutionary biology — Posted on 2025-01-22
1901 Multicilia dynamically transduce Shh signaling to regulate choroid plexus functions
He, L.; Mao, S.; Song, R.; Jin, S.; Pang, S.; Jovanovic, A.; Zimmerman, A.; Li, P.; Wu, X.; Wendland, M. F.; Lin, K.; Chen, W.-C.; Choksi, S. P.; Chen, G.; Holtzman, M. J.; Reiter, J. F.; Wan, Y.; Xuan, Z.; Xiang, Y. K.; Xu, C. S.; Upadhyayula, S.; Hess, H. F.
10.1101/2025.01.21.633415 — developmental biology — Posted on 2025-01-22
1907 Parameterization of intraoperative human microelectroderecordings: Linking action potential morphology to brainanatomy
Baker, M. R.; Klassen, B. T.; Jensen, M.; Valencia, G. O.; Heydari, H.; Ince, N. F.; Muller, K. R.; Miller, K. J.
10.1101/2025.01.20.633934 — neuroscience — Posted on 2025-01-22
1908 Gene therapy targeting sustained FGF23-ERK signaling alleviates kidney inflammation
Salas-Bastos, A.; Bardet, C.; Kopper, K.; Jauze, L.; Collaud, F.; Francois, A.; Chen, G.; Mohammadi, M.; Stockmann, C.; Sommer, L.; Loffing, J.; Ronzitti, G.; Pathare, G.
10.1101/2024.01.18.576116 — physiology — Posted on 2025-01-22
1910 Engineering Infrared Light Detection in Blind Human Retina Using Ultrasensitive Human TRPV1 Channels
Chevalier, M.; Fadel, F.; Majer, T.; Magda, D. P.; Gerendas, L.; Kilin, F.; Nagy, Z. Z.; Szabo, A.; Roska, B.; Testa-Silva, G.
10.1101/2025.01.08.631889 — bioengineering — Posted on 2025-01-22
1913 Controlled and polygynous mating in the black soldier fly: advancing breeding programs utilizing quantitative genetic designs
Jensen, K.; Thormose, S. F.; Noer, N. K.; Schou, T. M.; Kargo, M.; Gligorescu, A.; Noergaard, J. V.; Hansen, L. S.; Zaalberg, R. M.; Nielsen, H. M.; Kristensen, T. N.
10.1101/2024.09.09.611978 — animal behavior and cognition — Posted on 2025-01-22
1915 An episodic burst of massive genomic rearrangements and the origin of non-marine annelids
Vargas-Chavez, C.; Benitez-Alvarez, L.; Martinez-Redondo, G. I.; Alvarez-Gonzalez, L.; Salces-Ortiz, J.; Eleftheriadi, K.; Escudero, N.; Guiglielmoni, N.; Flot, J.-F.; Novo, M.; Ruiz-Herrera, A.; McLysaght, A.; Fernandez, R.
10.1101/2024.05.16.594344 — evolutionary biology — Posted on 2025-01-22
1916 Foraging niche partitioning of three Myotis bat species and marine fish consumption by Myotis pilosus in a subtropical East Asian region
Wei, X.; Poon, E. S. K.; Chung, J. C. T.; Chan, D. T. C.; Shek, C. T.; Tsui, W. C.; Zhao, H.; Sin, S. Y. W.
10.1101/2024.08.26.609698 — ecology — Posted on 2025-01-22
1917 Allee effects, spawning asynchrony, and mixed reproductive modes in a common mass spawning coral
Ricardo, G. F.; Doropoulos, C.; Babcock, R. C.; Adam, A. A. S.; Buccheri, E.; Robledo, N.; Uribe-Palomino, J.; Mumby, P. J.
10.1101/2024.12.06.627154 — ecology — Posted on 2025-01-22
1919 Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland
de Freitas Almeida, G. M.; Arriaga, I.; de Azevedo, B. L.; Leppänen, M.; Abrahao, J. S.; Andreani, J.; Zabeo, D.; Ravantti, J. J.; Abrescia, N. G.; Sundberg, L.-R.
10.1101/2024.10.16.618641 — microbiology — Posted on 2025-01-22
1920 Human milk oligosaccharide metabolism by Clostridium species suppresses inflammation and pathogen growth
Chapman, J. A.; Masi, A. C.; Beck, L. C.; Watson, H.; Young, G. R.; Browne, H. P.; Shao, Y.; Kiu, R.; Nelson, A.; Doyle, J. A.; Palmowski, P.; Lengyel, M.; Connolly, J. P. R.; Lamb, C. A.; Porter, A.; Lawley, T. D.; Hall, L. J.; Embleton, N. D.; Perry, J. D.; Berrington, J. E.; Stewart, C. J.
10.1101/2025.01.21.633585 — microbiology — Posted on 2025-01-22
1921 Muscle Cathepsin B treatment improves behavioral and neurogenic deficits in a mouse model of Alzheimer's Disease
Pinto, A.; Haytural, H.; Loss, C.; Alvarez, C.; Ertas, A.; Curtis, O.; Williams, A. R.; Murphy, G.; Salleng, K.; Gografe, S.; Altintas, A.; Kafri, T.; Barres, R.; Deshmukh, A. S.; van Praag, H.
10.1101/2025.01.20.633414 — neuroscience — Posted on 2025-01-22
1924 Single-cell spatial transcriptome reveals pathological features of human hippocampus with sclerosis
Wang, L.; Li, X.; Liu, Y.; Jin, B.; Wei, Y.; He, Y.; Ma, Y.; Wu, Z.; Gong, X.; An, Y.; Kong, X.; Xing, Y.; Ye, R.; Tao, Q.; Li, A.; Chang, M.; Pu, L.; Li, J.; Pang, L.; Zhou, D.; Song, C.; Liu, S.; Xu, X.; Liu, L.; Han, L.; Hong, Z.
10.1101/2025.01.21.633854 — neuroscience — Posted on 2025-01-22
1929 A self-supervised deep learning pipeline for segmentation in two-photon fluorescence microscopy
Ntiri, E. E.; Xu, T.; Rozak, M. W.; Attarpour, A.; Dorr, A.; Stefanovic, B.; Goubran, M.
10.1101/2025.01.20.633744 — neuroscience — Posted on 2025-01-22
1930 The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome
Jeon, S.; Park, J.; Moon, J. H.; Shin, D.; Li, L.; O'Shea, H.; Hwang, S. U.; Lee, H.-J.; Brimble, E.; Lee, J. W.; Clark, S.; Lee, S.-K.
10.1101/2025.01.21.634140 — neuroscience — Posted on 2025-01-22
1932 Longitudinal Trajectories of Cognition and Neural Metrics as Predictors of Persistent Distressing Psychotic-Like Experiences Across Middle Childhood and Early Adolescence
Karcher, N. R.; Dong, F.; Johnson, E. C.; Paul, S. E.; Kilciksiz, C. M.; Oh, H.; Schiffman, J.; Agrawal, A.; Bogdan, R.; Jackson, J. J.; Barch, D.
10.1101/2025.01.20.633817 — neuroscience — Posted on 2025-01-22
1935 A Shared Neural Network for Highly Liked and Disliked Music
Ripolles, P.; Belfi, A. M.; Kasdan, A.; Vessel, E. A.; Halpern, A. R.; Rowland, J.; Hopkins, R.; Starr, G. G.; Poeppel, D.
10.1101/2025.01.20.633989 — neuroscience — Posted on 2025-01-22
1937 Perinatal circadian desynchronization disrupts sleep and prefrontal cortex function in adult offspring
Roberts, B. L.; Wang, J.; Chargui, H.; Cupertino, N. C.; Sorensen, W.; Karatsoreos, I. N.
10.1101/2025.01.21.634103 — neuroscience — Posted on 2025-01-22
1938 Isolation and characterization of synaptic structures from human neural organoids
Oehlenschlaeger, M. S.; Criscuolo, L.; Jensen, P.; Sanchez, D. J. L.-D.; Sutcliffe, M.; Bhosale, S.; Bogetofte, H.; Tahir, M.; Jakobsen, L. A.; Pihl, M.; Brewer, J.; Schwammle, V.; Poulsen, F. R.; Freude, K.; Lancaster, M. A.; Robinson, P. J.; Larsen, M. R.
10.1101/2025.01.21.634055 — neuroscience — Posted on 2025-01-22
1939 Mapping brain function underlying naturalistic motor observation and imitation using high-density diffuse optical tomography
Yang, D.; George, T.; Sobolewski, C.; McMorrow, S.; Pacheco, C.; King, K.; Rochowiak, R.; Daniels-Day, E.; Park, S.; Speh, E.; Lidstone, D.; Santra, R.; Crocetti, D.; Nebel, M. B.; Tuncgenc, B.; Vidal, R.; Marrus, N. M.; Mostofsky, S. H.; Eggebrecht, A. T.
10.1101/2025.01.21.634109 — neuroscience — Posted on 2025-01-22
1940 Structural robustness and temporal vulnerability of the starvation-responsive metabolic network in liver of healthy and obese mice
Morita, K.; Hatano, A.; Kokaji, T.; Sugimoto, H.; Tsuchiya, T.; Ozaki, H.; Egami, R.; Li, D.; Terakawa, A.; Ohno, S.; Inoue, H.; Inaba, Y.; Suzuki, Y.; Matsumoto, M.; Takahashi, M.; Izumi, Y.; Bamba, T.; Hirayama, A.; Soga, T.; Kuroda, S.
10.1101/2024.06.17.599249 — systems biology — Posted on 2025-01-22
1941 PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP
Wang, J.; Shi, Y.; Wang, Y.; Shen, Y.; Liu, H.; Sun, S.; Wang, Y.; Zhou, X.; Zhou, Y.; Zeng, X.; Li, J.; Chen, Q.
10.1101/2024.07.23.604769 — cancer biology — Posted on 2025-01-22
1945 Sensory Appendage Protein triggers alarm to pyrethroid in Indian malarial vector Anopheles culicifacies
Saini, V.; Rohilla, P.; Srivastava, V.; Tandon, G.; Yadav, P.; Sankhala, N.; Singh, T.; Sharma, G.; De, T. D.; Tyagi, S.; Dixit, R.
10.1101/2025.01.21.634214 — animal behavior and cognition — Posted on 2025-01-22
1946 An Event-Related Potential Study of Onset Primacy in Visual Change Detection
Van Pelt, J.; Lowe, B. G.; Robinson, J. E.; Donaldson, M. J.; Johnston, P.; Yamamoto, N.
10.1101/539932 — neuroscience — Posted on 2025-01-22
1950 Comparison of Activities of Transcription Factor NF-κB from Two Jellyfish Models
Williams, L. M.; Wang, W.; Grigoryeva, A. V.; Navarro-Rosado, A.; Peart, J. A.; Calderon, A.; Gill, C. L.; Alsante, K. M.; Lackstrom, A. T.; Molecular Biology Laboratory, ; Weissbourd, B.; Wang, M.; DiRusso, C. J.; Cohen, L. B.; Wunderlich, Z.; Grone, B. P.; Gilmore, T. D.
10.1101/2025.01.21.634164 — molecular biology — Posted on 2025-01-22
1952 Buffer specificity of ionizable lipid nanoparticle transfection efficiency and bulk phase transition
Carucci, C.; Philipp, J.; Müller, J. A.; Sudarsan, A.; Kostyurina, E.; Blanchet, C. E.; Schwierz, N.; Parsons, D. F.; Salis, A.; Rädler, J. O.
10.1101/2025.01.17.633509 — biophysics — Posted on 2025-01-21
1953 Delivery of a chemically modified noncoding RNA domain improves dystrophic myotube function
Niasse-Sy, Z.; Zhao, B.; Lenardic, A.; Luong, H. T.; Bar-Nur, O.; Auwerx, J.; Wohlwend, M.
10.1101/2025.01.17.633605 — bioengineering — Posted on 2025-01-22
1954 Characterization of Microbubble Cavitation in Theranostic Ultrasound-mediated Blood-Brain Barrier Opening and Gene Delivery
Tsitsos, F. N.; Batts, A. J.; Jimenez, D. A.; Li, C.; Ji, R.; Bae, S.; Theodorou, A.; Gorman, S. L.; Konofagou, E. E.
10.1101/2025.01.17.633644 — bioengineering — Posted on 2025-01-22
1955 AI.zymes - A modular platform for evolutionary enzyme design
Merlicek, L. P.; Neumann, J.; Lear, A.; Degiorgi, V.; de Waal, M.; Cotet, T.-S.; Mulholland, A. J.; Bunzel, H. A.
10.1101/2025.01.18.633707 — bioengineering — Posted on 2025-01-22
1959 Recovering ecological interactions by mining non-target data from whole genome re-sequencing projects
Jones, M.; Rastas, P. M. A.; Chacon-Duque, J. C.; DiLeo, M.; Nair, A.; Oostra, V.; Saastamoinen, M.; Duplouy, A.
10.1101/2025.01.17.633498 — ecology — Posted on 2025-01-21
1961 Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva
Wits, M.; Gomez-Suarez, N.; Lopez, A. D.; Farfan, N.; Bekedam, F.; Sampadi, B.; Rotman, S.; Lopez, D. R.; Marquez, J. B.; Arendzen, C.; Freund, C.; Veelen, P. v.; Valldeperas, A. L.; Man, F. d.; Ventura, F.; Goumans, M.-J.; Sanchez-Duffhues, G.
10.1101/2025.01.21.634061 — molecular biology — Posted on 2025-01-21
1962 GC-MS Profiling and In vitro Antibacterial, Anti-Biofilm and Anti-adhesive Activities of Tamarix ericoides Rottl. Leaf Extract Against Catheter-Associated Urinary Tract Infectious Agents
Poyil, M. M.; Alsharif, M. H. K.; El-Bidawy, M. H.; Alqahtani, M. S.; Alarabi, T. G. M.; Albadrani, A. A.; Hamid, A. A. M.; Arafah, A. M. R.; Abdel Tawab, A.; Alqasem, S.; Al-Gonaim, A.
10.1101/2025.01.21.634068 — microbiology — Posted on 2025-01-21
1964 Small molecule-controlled gene expression: Design of drug-like high affinity small molecule modulators of a custom-made riboswitch
Hedwig, V.; Spoering, M.; Aspnes, G.; Gottschling, D.; Klein, H.; Klugmann, M.; Kreuz, S.; Ries, B.; Schnapp, G.; Scharsich, S.; Hartig, J.; Hucke, O.
10.1101/2025.01.21.634073 — synthetic biology — Posted on 2025-01-21
1966 Revisiting the need for mRNA nucleoside modification in CAR T cell engineering
Kahwaji, N.; Kotzian, N.; Prinz, J. M.; Pu, Y.; Kath, J.; Picht, S.; Hiller, A. L.; Dunne, C. M.; Launspach, M.; Kleyer, A.; Simon, D. N.; Wagner, D. L.; Pichon, C.; Kroenke, G.; Schmueck-Henneresse, M.; Volk, H.-D.; Gossen, M.; Drzeniek, N. M.
10.1101/2025.01.21.630650 — bioengineering — Posted on 2025-01-21
1968 Peptide Design through Binding Interface Mimicry
Kong, X.; Jiao, R.; Lin, H.; Guo, R.; Huang, W.; Ma, W.-Y.; Wang, Z.; Liu, Y.; Ma, J.
10.1101/2025.01.21.634006 — biochemistry — Posted on 2025-01-21
1969 Carbon monoxide exposure stimulates growth and activity of primary producers in diverse soil ecosystems
Xu, Y.; Teng, Y.; Liao, J.; Leung, P. M.; Dai, S.; Sun, Y.; Hu, W.; Wang, H.; Li, Y.; Huang, Y.; Guo, Z.; Pan, X.; Dong, X.; Luo, Y.; Greening, C.
10.1101/2025.01.21.634059 — biochemistry — Posted on 2025-01-21
1970 USP1 acts as a chaperone for HSFA2 and plays a crucial role in thermopriming in Arabidopsis
Hirt, H.; Shekhawat, K.; Fatima, A.; Alhoraibi, H. M.; Abulfaraj, A. A.; Rayapuram, N.; Manickam, P.
10.1101/2025.01.21.634064 — biochemistry — Posted on 2025-01-21
1971 Molecular sorting of nitrogenase catalytic cofactors
Salinero-Lanzarote, A.; Lian, J.; Namkoong, G.; Suess, D. L. M.; Rubio, L. M.; Dean, D. R.; Perez-Gonzalez, A.
10.1101/2025.01.21.634024 — biochemistry — Posted on 2025-01-21
1974 Phosphoinositide- and Collybistin-Dependent Synaptic Clustering of Gephyrin
Burdina, N.; Liebsch, F.; Macha, A.; Ortuno Gil, J. L.; Frommelt, P.; Rais, I.; Basler, F.; Poepsel, S.; Schwarz, G.
10.1101/2025.01.20.633899 — biochemistry — Posted on 2025-01-21
1976 Minimization of gene editing off-target effects by tissue restriction of expression
Kim, N.-G.; Aubert, M.; Haick, A. K.; Massa, P. A.; Loprieno, M. A.; Walter, M.; Kim, H. G.; Nunley, B. E.; Xie, H.; Stensland, L.; Klouser, L. M.; Perez-Osorio, A. C.; Stone, D.; Roychoudhury, P.; Jerome, K. R.
10.1101/2025.01.21.634017 — molecular biology — Posted on 2025-01-21
1977 The Specific Genetic Markers to Diagnose Xanthomonads Infecting Pepper and Tomato Plants
Can, A.; Abdul-Baasit, A.-N.; Belen, I. N.; Capar, U.; Sener, B.; Basaran, C. C.; Sulu, S. M.; Kusek, M.; Silme, R. S.; Baysal, O.
10.1101/2025.01.21.634051 — molecular biology — Posted on 2025-01-21
1978 Local nucleolar surveillance mechanisms maintain rDNA stability
Liu, R.; Xuan, J.; Pan, J.; Sundramurthi Chelliah, S.; Dmello, R.; Cowley, K. J.; Mendez, S.; Zhang, Y.; Gitareja, K.; Wakefield, M.; Deans, A.; Scott, C.; Chan, K.; Simpson, K. J.; Kang, J.; Sanij, E.
10.1101/2025.01.20.633984 — molecular biology — Posted on 2025-01-21
1979 Host environment shapes filarial parasites fitness and Wolbachia endosymbionts dynamics
FERCOQ, F.; Cormerais, C.; Remion, E.; Gal, J.; Plisson, J.; Fall, A.; Alonso, J.; Lhermitte-Vallarino, N.; Hübner, M. P.; Kohl, L.; Landmann, F.; Martin, C.
10.1101/2025.01.21.632327 — microbiology — Posted on 2025-01-21
1980 Human milk oligosaccharide metabolism by Clostridium species suppresses inflammation and pathogen growth
Chapman, J. A.; Masi, A. C.; Beck, L. C.; Watson, H.; Young, G. R.; Browne, H. P.; Shao, Y.; Kiu, R.; Nelson, A.; Doyle, J. A.; Palmowski, P.; Lengyel, M.; Connolly, J. P. R.; Lamb, C. A.; Porter, A.; Lawley, T. D.; Hall, L. J.; Embleton, N. D.; Perry, J. D.; Berrington, J. E.; Stewart, C. J.
10.1101/2025.01.21.633585 — microbiology — Posted on 2025-01-21
1986 Novel antimicrobial activity of photoactive compounds originally synthesized for industrial applications
Ezquerra-Aznarez, J. M.; Alonso-Roman, R.; Lucia, A.; Andreu, R.; Franco, S.; Ainsa, J. A.; Ramon-Garcia, S.
10.1101/2025.01.21.634129 — microbiology — Posted on 2025-01-21
1987 Unravelling termite evolution with 47 high-resolution genome assemblies
Liu, C.; Aumont, C.; Mikhailova, A.; Audisio, T.; Hellemans, S.; Weng, Y.-M.; He, S.; Clitheroe, C.; wang, Z.; Haifig, I.; Sillam-Dusses, D.; Bucek, A.; Tokuda, G.; Sobotnik, J.; Harrison, M.; Mcmahon, D.; bourguignon, t.
10.1101/2025.01.20.633303 — genomics — Posted on 2025-01-21
1991 Transient pH changes drive vacuole formation in enzyme-polymer condensates
Modi, N.; Nimiwal, R.; Liao, J.; Li, Y.; Bishop, K. J.; Obermeyer, A. C.
10.1101/2025.01.16.633379 — biophysics — Posted on 2025-01-21
1992 Comparison candidate Tick-borne encephalitis virus vaccines based on mRNA, adenovirus serotype 25 and chimera of YFV vaccine strain
Kuznetsova, N. A.; Gushchin, V. A.; Marchuk, E. V.; Siniavin, A.; Kleymenov, D. A.; Nikiforova, M.; Zubkova, O. V.; Vavilova, I. V.; Ozharovskaia, T. A.; Mazunina, E. P.; Bykonia, E. N.; Bogdanov, E. Y.; Zolotar, A. N.; Shidlovskaya, E. V.; Usachev, E. V.; Usacheva, O. V.; Shatalov, A. G.; Zlobin, V. I.; Logunov, D. Y.; Gintsburg, A. L.
10.1101/2025.01.16.633390 — immunology — Posted on 2025-01-21
1993 Multiparametric optimization of human primary B-cell cultures using Design of Experiments
Rovsing, A. B.; Green, K.; Jensen, L.; Nielsen, I. H.; Mikkelsen, J. G.; Degn, S. E.
10.1101/2025.01.16.633474 — immunology — Posted on 2025-01-21
1994 Protective mechanisms against Alzheimer's Disease in APOE3-Christchurch homozygous astrocytes
Tian, X.; Rivera, E. K.; Nikitina, A. A.; Hwang, I.; Smith, J. A.; Cho, Y. J.; Sala-Jarque, J.; DeBose, A.; Andriola, C.; Gollan-Meyer, T.; Kosik, K. S.
10.1101/2025.01.21.634115 — neuroscience — Posted on 2025-01-21
1996 Distinct cell types along thick ascending limb express pathways for monovalent and divalent cation transport
Bahena-Lopez, J.; Demirci, H.; Smorodchenko, A.; Su, X.-T.; Nelson, J.; Yang, C.-L.; Wang, W.-H.; Curry, J.; Duan, X.-P.; Sharkovska, Y.; Liu, R.; Yilmaz, D. E.; Quintanova, C.; Emberly, K.; Emery, B.; Himmerkus, N.; Bleich, M.; Bachmann, S.; Ellison, D. H.
10.1101/2025.01.16.633282 — physiology — Posted on 2025-01-21
1997 Monitoring fungicide resistance frequencies -- a case study of barley net blotch
Knight, N. L.; Adhikari, K. C.; Mair, W. J.; Dodhia, K. N.; Zulak, K. G.; Lopez-Ruiz, F. J.
10.1101/2025.01.16.633467 — pathology — Posted on 2025-01-21
2004 Intersecting Transcriptomic Landscapes of Hypertension and Kidney Function in African American Women
Abbas, M.; Martin, P.; Lindsey, M.; Bennett, E. S.; Brown, T. L.; Nzerue, C.; Williams, C. R.; Gaye, A.
10.1101/2025.01.16.633488 — genomics — Posted on 2025-01-21
2007 The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration
Li, J. S. S.; Liu, Y.; Kim, A.-R.; Qadiri, M.; Xu, J.; Xia, B.; Binari, R.; Asara, J. M.; Hu, Y.; Perrimon, N.
10.1101/2025.01.16.633419 — genetics — Posted on 2025-01-21
2008 Tetranucleotide frequencies differentiate genomic boundaries and metabolic strategies across environmental microbiomes
Kellom, M.; Berg, M.; Chen, A.; Chu, K.; Clum, A.; Huntemann, M.; Ivanova, N.; Kyrpides, N. C.; Mukherjee, S.; Reddy, T. B. K.; Roux, S.; Seshadri, R.; Szabo, G.; Varghese, N.; Woyke, T.; Eloe-Fadrosh, E. A.
10.1101/2025.01.16.633425 — ecology — Posted on 2025-01-21
2009 Defining the cell and molecular origins of the primate ovarian reserve
Wamaitha, S. E.; Rojas, E. J.; Monticolo, F.; Hsu, F.-M.; Sosa, E.; Mackie, A. M.; Oyama, K.; Custer, M.; Murphy, M.; Laird, D. J.; Shu, J.; Hennebold, J. D.; Clark, A.
10.1101/2025.01.21.634052 — developmental biology — Posted on 2025-01-21
2010 A nonhuman primate model mirrors human congenital cytomegalovirus infection and reveals a spectrum of vertical transmission outcomes
Manuel, T. D.; Mostrom, M. J.; Crooks, C.; Davalos, A.; Barfield, R.; Scheef, E. A.; Kendall, S.; Midkiff, C. C.; Sprehe, L. M.; Trexler, M.; Boquet, F.; Shroyer, M.; Danner, V.; Doyle-Meyers, L.; Mirza, A.; Lammi, S.; Otero, C. E.; Lee, M.; Rogers, L.; Kowalik, T.; Chan, C.; Permar, S. R.; Blair, R. V.; Frueh, K.; Malouli, D.; Granek, J. A.; Owzar, K.; Kaur, A.
10.1101/2025.01.16.633406 — immunology — Posted on 2025-01-21
2011 Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT
McManus, D.; Copsel, S.; Pfieffer, B. J.; Wolf, D.; Barreras, H.; Ma, S.; Khodor, A.; Komai, S.; Burgos da Silva, M.; Hazime, H.; Gallardo, M.; van den Brink, M. R.; Abreu, M. T.; Hill, G. R.; Perez, V. L.; Levy, R. B.
10.1101/2025.01.16.633453 — immunology — Posted on 2025-01-21
2012 Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity
Su, J.; Gupta, R.; Van Hoof, S.; Kreye, J.; Pruss, H.; Spielman, B.; Brimberg, L.; Volpe, B. T.; Huerta, P. T.; Diamond, B.
10.1101/2025.01.16.633238 — immunology — Posted on 2025-01-21
2014 A single dorsal vagal complex circuit mediates the aversive and anorectic responses to GLP1R agonists
Yacawych, W. T.; Wang, Y.; Zhou, G.; Hassan, S.; kernodle, s.; Sass, F.; Devaus, M.; Wu, I.; Rupp, A.; Tomlinson, A. J.; Lin, Z.; Secher, A.; Raun, K.; Pers, T.; Seeley, R. J.; Myers, M. G.; Qui, W.
10.1101/2025.01.21.634167 — neuroscience — Posted on 2025-01-21
2015 Working memory shapes neural geometry in human EEG over learning
Wojcik, M. J.; Li, A. X.; Wasmuht, D.; Stroud, J. P.; Stokes, M. G.; Myers, N. E.; Hunt, L. T.
10.1101/2025.01.21.634110 — neuroscience — Posted on 2025-01-21
2019 CHD2 Dosage Ties Autolysosomal Pathway to Cortical Maturation in Disease and Evolution
Leonardi, O.; Lewerissa, E.; Aprile, D.; Barakat, T. S.; Culotta, L.; Deng, R.; Haazen, L.; Linda, K.; Majoie, M.; Mordelt, A.; Ortale, A.; Oudakker, A.; Prazzoli, F.; Puvogel, S.; Scheefhals, N.; Schelhaas, H. J.; Schoenmaker, C.; van Hugte, E.; van Bokhoven, H.; Verhoeven, J.; Vitriolo, A.; Boeckx, C.; Testa, G.; Kasri, N. N.
10.1101/2025.01.21.634145 — neuroscience — Posted on 2025-01-21
2020 High-throughput assessment of exercise-induced adaptations and muscle function in health and ageing
Malita, A.; Texada, M. J.; Kubrak, O.; Lassen, M.; Skakkebaek, A. H.; Bradic, I.; Larsen, M. R.; Ahrentloev, N.; Rewitz, K.
10.1101/2025.01.16.633393 — physiology — Posted on 2025-01-21
2023 ADAR1 Regulates Lipid Remodeling through MDM2 to Dictate Ferroptosis Sensitivity
Kung, C.-P.; Terzich, N. D.; Ilagan, M. X. G.; Prinsen, M. J.; Kaushal, M.; Kladney, R. D.; Weber, J. H.; Mabry, A. R.; Torres, L. S.; Bramel, E. R.; Freeman, E. C.; Sabloak, T.; Cottrell, K. A.; Ryu, S.; Weber, W. M.; Maggi, L.; Shriver, L. P.; Patti, G. J.; Weber, J. D.
10.1101/2025.01.16.633410 — cancer biology — Posted on 2025-01-21
2026 Solution conformational differences between conventional and CENP-A nucleosomes are accentuated by reversible deformation under high pressure
Gupta, K.; Sekulic, N.; Allu, P. K.; Sapp, N.; Huang, Q.; Sarachan, K.; Christensen, M.; Lund, R.; Krueger, S.; Curtis, J. E.; Gillilan, R. E.; Van Duyne, G. D.; Black, B. E.
10.1101/2025.01.16.633457 — biophysics — Posted on 2025-01-21
2031 Using landscape biodiversity metrics to assess rewilding: a space-for-time comparison between the Knepp Estate and an agricultural baseline at Boothby Wildland
Pates, N. J.; Boyce, B. B.; Crawley, M. J.; de Klee, I.; Green, P.; Hodge, J. A.; Estrada, C.; Loughlin, E. K.; Learmonth, R.; Moye, T. J.; Pearce, S. I.; Sherlock, M.; Pearse, W. D.
10.1101/2025.01.16.633386 — ecology — Posted on 2025-01-21
2033 The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8+ T cell responses
Phan, A. T.; Aunins, E.; Cruz-Morales, E.; Dwivedi, G.; Bunkofske, M.; Eberhard, J. N.; Aldridge, D. L.; Said, H.; Banda, O.; Tam, Y.; Christian, D. A.; Vonderheide, R. H.; Kedl, R. M.; Weissman, D.; Alameh, M.-G.; Hunter, C. A.
10.1101/2025.01.16.633383 — immunology — Posted on 2025-01-21
2034 Transfusion of allogenic murine HOD red blood cells preferentially induces low-affinity, short-lived IgG antibodies that are germinal center independent
Medved, J.; Arneja, A.; Moscovich, T. C.; Shah, N.; Muppidi, R. J.; Burnett, E. D.; Boscia, A. R.; Hester, B. N.; Maram, J.; Raghavan, R.; Ireland, S. A.; Berberian, M. B.; Stern-Green, E. A.; Kodali, A. S.; Niebuhr, C. S.; Salazar, J. E.; Santhanakrishnan, M.; Hudson, K. E.; Zimring, J. C.; Hendrickson, J. E.; Luckey, C. J.
10.1101/2025.01.16.633377 — immunology — Posted on 2025-01-21
2038 The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscle.
Prabakaran, A. D.; Chung, H.-J.; McFarland, K.; Govindarajan, T.; Soussi, F. E. A.; Durumutla, H. B.; Villa, C.; Piczer, K.; Latimer, H.; Werbrich, C.; Akinborewa, O.; Horning, R.; Quattrocelli, M.
10.1101/2024.03.28.586997 — physiology — Posted on 2025-01-21
2042 Overcoming challenges of reproducibility and variability for the Clostridioides difficile typification
Bravo-Anton, L.; Guerrero-Lopez, A.; Schmidt-Santiago, L.; Sevilla-Salcedo, C.; Blazquez-Sanchez, M.; Rodriguez-Temporal, D.; Rodriguez-Sanchez, B.; Gomez-Verdejo, V.
10.1101/2024.10.29.620907 — microbiology — Posted on 2025-01-21
2043 Phageome transfer from gut to circulation and its regulation by human immunity
Szymczak, A.; Gembara, K.; Ferenc, S.; Majewska, J.; Miernikiewicz, P.; Harhala, M.; Rybicka, I.; Strapagiel, D.; Slomka, M.; Lach, J.; Gnus, J.; Staczek, P.; Witkiewicz, W.; Dabrowska, K.
10.1101/2024.06.05.597592 — microbiology — Posted on 2025-01-21
2045 "Dark taxonomy": a new protocol for overcoming the taxonomic impediments for dark taxa and broadening the taxon base for biodiversity assessment
Meier, R.; Srivathsan, A.; Oliveira, S. S.; Balbi, M. I. P. A.; Ang, Y.; Yeo, D.; Kjaerandsen, J.; Amorim, D. d. S.
10.1101/2023.08.31.555664 — zoology — Posted on 2025-01-21
2046 An integrative taxonomic treatment of the Mycetophilidae (Diptera: Bibionomorpha) from Singapore reveals 115 new species on 730km2
Amorim, D. d. S.; Oliveira, S. S.; Balbi, M. I. P. A.; Ang, Y.; Torres, A. G.; Yeo, D.; Srivathsan, A.; Meier, R.
10.1101/2023.09.02.555672 — zoology — Posted on 2025-01-21
2048 Rep structures comprise metastable intermediates between open and closed states whose transitional kinetics are tuned by the ionic environment
Howard, J. A. L.; Ambrose, B.; Abdelhamid, M. A. S.; Alevropoulos-Borrill, A.; Ejaz, A.; Dresser, L.; Dienerowitz, M.; Quinn, S. D.; Squires, A. H.; Noy, A.; Craggs, T. D.; Leake, M. C.
10.1101/2024.07.12.603287 — biophysics — Posted on 2025-01-21
2049 CARDBiomedBench: A Benchmark for Evaluating Large Language Model Performance in Biomedical Research
Bianchi, O.; Willey, M.; Alvarado, C. X.; Danek, B.; Khani, M.; Kuznetsov, N.; Dadu, A.; Shah, S.; Koretsky, M. J.; Makarious, M. B.; Weller, C.; Levine, K. S.; Kim, S.; Jarreau, P.; Vitale, D.; Marsan, E.; Iwaki, H.; Leonard, H.; Bandres-Ciga, S.; Singleton, A. B.; Nalls, M. A.; Mokhtari, S.; Khashabi, D.; Faghri, F.
10.1101/2025.01.15.633272 — bioinformatics — Posted on 2025-01-21
2051 Ancient gene clusters initiate monoterpenoid indole alkaloid biosynthesis and C3 stereochemistry inversion
Hwang, J.; Kirshner, J.; Deschenes, D. A. R.; Richardson, M. B.; Fleck, S. J.; Guo, J.; Perley, J. O.; Shahsavarani, M.; Garza-Garcia, J. J. O.; Seveck, A. D.; Doiron, S. S.; Mai, Z.; Silliphant, S. N.; Calhoun, L.; Gao, D.; Lian, J.; Deslongchamps, G.; Albert, V. A.; Qu, Y.
10.1101/2025.01.07.631695 — biochemistry — Posted on 2025-01-21
2052 Deep learning from videography as a tool for measuring E. coli infection in poultry
Scheidwasser, N.; Poulsen, L. L.; Leow, P. R.; Khurana, M. P.; Iglesias-Carrasco, M.; Laydon, D. J.; Donnelly, C. A.; Bojesen, A. M.; Bhatt, S.; Duchene, D. A.
10.1101/2024.11.20.624075 — animal behavior and cognition — Posted on 2025-01-21
2053 The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential
Morabito, R. D.; Tatarakis, D.; Swick, R.; Stettnisch, S.; Schilling, T. F.; Horsfield, J. A.; Martin, B. L.
10.1101/2025.01.16.633481 — developmental biology — Posted on 2025-01-21
2054 H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
Oak, M. S.; Stock, M.; Mezes, M.; Straub, T.; Hynes-Allen, A. M.; van den Ameele, J.; Forne, I.; Ettinger, A.; Imhof, A.; Scialdone, A.; Hoermanseder, E. B.
10.1101/2025.01.20.633863 — developmental biology — Posted on 2025-01-21
2055 Mapping spatially-resolved transcriptomes in systemic sclerosis
Li, Z.; Rigau, A. R.; Xie, W.; Shao, X.; Li, Y.-N.; Matei, A. E.; Zou, H.; Pinello, L.; Distler, J. H. W.; He, R.; Liang, M.
10.1101/2025.01.14.632962 — immunology — Posted on 2025-01-21
2056 Nanophysiology Approach Reveals Diversity in Calcium Microdomains across Zebrafish Retinal Bipolar Ribbon Synapses
Rameshkumar, N.; Shrestha, A. P.; Boff, J. M.; Hoon, M.; Matveev, V.; Zenisek, D.; Vaithianathan, T.
10.1101/2024.11.01.617078 — neuroscience — Posted on 2025-01-21
2058 Neurometabolic predictors of mental effort in the frontal cortex
Barakat, A.; Clairis, N.; Brochard, J.; Pessiglione, M.; Godin, J.-P.; Cuenoud, B.; Xin, L.; Sandi, C.
10.1101/2024.01.23.576854 — neuroscience — Posted on 2025-01-21
2059 Pushing the boundaries of MEG based on optically pumped magnetometers towards early human life
Corvilain, P.; Wens, V.; Bourguignon, M.; Capparini, C.; Fourdin, L.; Ferez, M.; Feys, O.; De Tiege, X.; Bertels, J.
10.1101/2023.10.28.564455 — neuroscience — Posted on 2025-01-21
2064 Epigenetic priming of neural progenitors by Notch enhances Sonic hedgehog signaling and establishes gliogenic competence
Tran, L. N.; Shinde, A.; Schuster, K. H.; Sabaawy, A.; Dale, E.; Welch, M. J.; Isner, T. J.; Nunez, S. A.; Garcia-Moreno, F.; Sagerström, C. G.; Appel, B. H.; Franco, S. J.
10.1101/2025.01.20.633996 — developmental biology — Posted on 2025-01-21
2066 Type-I nNOS neurons orchestrate cortical neural activity and vasomotion
Turner, K.; Brockway, D.; Hossain, M. S.; Griffith, K.; Greenawalt, D.; Zhang, Q.; Gheres, K.; Crowley, N.; Drew, P. J.
10.1101/2025.01.21.634042 — neuroscience — Posted on 2025-01-21
2068 DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal lobar degeneration genetic risk-associated loci
Rambarack, N.; Fodder, K.; Murthy, M.; Toomey, C.; de Silva, R.; Humphrey, J.; Raj, T.; Lashley, T.; Bettencourt, C.
10.1101/2025.01.21.634065 — neuroscience — Posted on 2025-01-21
2069 GAL-101 prevents amyloid beta-induced membrane depolarization in two different types of retinal cells
Pizzi, E.; Gornati, S.; Stabilini, S.; Brambilla, D.; Mercurio, C. A.; Russ, H.; Parsons, C. A.; Mazzanti, M.
10.1101/2025.01.21.634046 — neuroscience — Posted on 2025-01-21
2071 Daily intermittent fasting is an effective multiscale treatment in preclinical models of absence epilepsy
Rulhe, C.; Thirard, S.; Aparicio Arias, J.; Makrini, L.; Fauvelle, F.; Beyne, E.; Dauve, A.; Bouschet, T.; Valjent, E.; Bertaso, F.
10.1101/2025.01.21.634091 — neuroscience — Posted on 2025-01-21
2072 Sound-Enhanced Sleep Depth Reduces Traumatic Brain Injury Damage and Sequelae and Supports Microglial Response
Moreira, C. C. G.; Muellner, A.; Goenel, M.; Hofmann, P.; Teixeira, F.; Paolicelli, R. C.; Dias, I.; Nemirovsky, S. I.; Baumann, C. R.; Noain, D.
10.1101/2025.01.21.634054 — neuroscience — Posted on 2025-01-21
2073 Estimating the motor exploration in reinforcement learning
Zai, A. T.; Lorenz, C.; Srikantharajah, S.; Giret, N.; Hahnloser, R. H.
10.1101/2025.01.21.634056 — neuroscience — Posted on 2025-01-21
2075 The inflammasome adaptor protein ASC triggers immunometabolic dysregulation induced by dysbiosis during obesity
Martinez-Garcia, J. J.; Rodriguez, S.; Guijarro, A.; Quevedo-Romero, I.; Mateo, S. V.; Molina-Lopez, C.; Hurtado-Navarro, L.; Baroja-Mazo, A.; Pelegrin, P.
10.1101/2025.01.16.633385 — immunology — Posted on 2025-01-21
2081 Advanced Manufacturing of Coil-Reinforced Multilayer Vascular Grafts to Optimize Biomechanical Performance
Robinson, A.; Jiang, D.; Nkansah, A.; Leung, J.; Herrera Duran, J.; Laude, M.; Craig, J.; Guo, L.; Timmins, L.; Cosgriff-Hernandez, E.
10.1101/2025.01.16.633374 — bioengineering — Posted on 2025-01-21
2085 Description of a novel extremophile green algae, Chlamydomonas pacifica, and its potential as a biotechnology host
Dutra Molino, J. V.; Oliver, A.; Sethuram, H.; Kang, K.; Saucedo, B.; Diaz, C. J.; Gupta, A.; Jen, L. J.; Torres-tiji, Y.; Hidasi, N.; Badary, A.; Jenkins, H.; Fields, F. J.; Simkovsky, R.; Mayfield, S.
10.1101/2024.09.03.611117 — molecular biology — Posted on 2025-01-21
2088 Collective directional memory controls the range of epithelial cell migration
Canever, H.; Lachuer, H.; Delaunay, Q.; Sipieter, F.; Auduge, N.; Girard, P. P.; Borghi, N.
10.1101/2023.12.08.570811 — biophysics — Posted on 2025-01-21
2091 Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing
Zhou, J.; Zhao, D.; Li, J.; Kong, D.; Li, X.; Zhang, R.; Liang, Y.; Gao, X.; Qian, Y.; Wang, D.; Chen, J.; Lai, L.; Han, Y.; Li, Z.
10.1101/2024.04.17.589933 — biochemistry — Posted on 2025-01-21
2093 Time-resolved immune dynamics in rheumatoid arthritis under Methotrexate therapy
Preglej, T.; Tosevska, A.; Brinkmann, M.; Schatzlmaier, P.; Simader, E.; Sieghart, D.; Hofer, P.; Krausgruber, T.; Dobnikar, L.; Bock, C.; Karonitsch, T.; Kain, R.; Stockinger, H.; Ellmeier, W.; Aletaha, D.; Goeschl, L.; Bonelli, M.
10.1101/2025.01.14.629357 — genomics — Posted on 2025-01-21
2094 Manual versus automatic annotation of transposable elements: case studies in Drosophila melanogaster and Aedes albopictus, balancing accuracy and biological relevance
Carrasco-Valenzuela, T.; Marino, A.; Storer, J. M.; Bonnici, I.; Mazzoni, C. J.; Fontaine, M. C.; Haudry, A.; Boulesteix, M.; Fiston-Lavier, A.-S.
10.1101/2025.01.10.632341 — genomics — Posted on 2025-01-21
2095 The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo
Shi, M.; Li, J.; Liu, X.; Liu, K.; He, L.; Pu, W.; Weng, W.; Zhang, S.; Zhao, H.; Lui, K.; Zhou, B.
10.1101/2024.04.23.590680 — genetics — Posted on 2025-01-21
2096 Convergent gene expression in epithelial cells illuminates the evolution of uterine receptivity
Brulport, A.; Gazda, M. A.; Liorzou, E.; Daunesse, M.; Raquillet, B.; Lepelletier, A.; Sopena-Rios, M.; Regnard, P.; Fellmann, L.; Faccin, L.; Garbit, S.; Cermolacce, A.; Kondova, I.; Raliou, M.; Marcellin, L.; Abo, C.; Doridot, L.; Berthelot, C.
10.1101/2024.03.13.584751 — evolutionary biology — Posted on 2025-01-21
2097 Dominance reversal maintains large-effect resistance polymorphism in temporally varying environments
Karageorgi, M.; Lyulina, A. S.; Bitter, M. C.; Lappo, E.; Greenblum, S. I.; Mouza, Z. K.; Tran, C. T.; Huynh, A. V.; Oken, H.; Schmidt, P.; Petrov, D. A.
10.1101/2024.10.23.619953 — evolutionary biology — Posted on 2025-01-21
2100 Histone deacetylase-1 is required for epigenome stability in Neurospora crassa
Ebot-Ojong, F.; Ferraro, A. R.; Kaddar, F.; Hull-Crew, C.; Scadden, A. W.; Klocko, A. D.; Lewis, Z. A.
10.1101/2025.01.17.633486 — genetics — Posted on 2025-01-21
2103 Inversions Dominate Evolution in the Highly Admixed European Sardine (Sardina pilchardus)
Sabatino, S. J.; Cabezas, M. P.; Pereira, P.; Garrido, S.; Santos, A.; Santos, P. J. T.; Carneiro, M.; Louro, B.; Cox, C.; Canario, A.; Verissimo, A.
10.1101/2025.01.15.633256 — genomics — Posted on 2025-01-21
2106 Development of a novel murine model of in-stent neoatherosclerosis
Liu, J.; Geremew, D.; Sandeman, L.; Nankivell, V.; Chen, R.; Xiang, L.; Solly, E.; Stretton, L. G.; Escarbe, S.; Blake, S.; McLaughlin, R. A.; Tan, J. T. M.; Psaltis, P. J.; Bonder, C. S.; Li, J.; Wu, Y.; Bursill, C. A.
10.1101/2025.01.17.633685 — cell biology — Posted on 2025-01-21
2107 External and Internal Load Profiles of Male and Female Participants during a Walking Football Practice
da Costa, J. A. H. C.; Pereira, C.; Barbosa, A.; Seabra, A.; Brito, J.; Pinto, A.; Martins, C.; Moreira, R.; Goncalves, B.
10.1101/2025.01.15.633234 — physiology — Posted on 2025-01-21
2108 In depth profiling of the cancer proteome from the flowthrough of standard RNA-preparation kits for precision oncology
Mundt Madsen, F.; Nielsen, A. B.; Wang, J.; Duel, J. K.; Yde, C. W.; Eriksen, M. A.; Lassen, U.; Nielsen, F. C.; Rohrberg, K.; Mann, M.
10.1101/2023.05.12.540582 — cancer biology — Posted on 2025-01-21
2113 Density-dependent expression of epitranscriptomic, stress, and appetite regulating genes in Atlantic salmon
Frapin, M.; Quispe, L.; Troka, J.; Prokkola, J. M.; Laurikainen, O.; Hyvärinen, P.; Primmer, C. R.; Aykanat, T.; Ahi, E. P.
10.1101/2025.01.19.633827 — molecular biology — Posted on 2025-01-21
2114 Diverse Defence Systems and Prophages in Human-Associated Bifidobacterium Species Reveal "Arms Race" Dynamics
Docherty, J.; Cook, R.; Kiu, R.; Dyball, X.; Brown, T. L.; Kujawska, M.; lily-Smith, R.; Phillips, S.; Watt, R.; Telatin, A.; Tiwari, S.; Hall, L. J.; Adriaenssens, E. M.
10.1101/2025.01.20.633837 — microbiology — Posted on 2025-01-21
2117 The complex interplay between microalgae and the microbiome in production raceways
Traver-Azuara, J.; Giner, C. R.; Garcia-Comas, C.; Sanchez-Zurano, A.; Ciardi, M.; Acien, G.; Bondarenko, S.; Obiol, A.; Massana, R.; Sala, M. M.; Logares, R.; Cermeno, P.
10.1101/2025.01.20.633910 — microbiology — Posted on 2025-01-21
2120 Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2
Subramaniam, S.; Napoleon, M. A.; Lotfollahzadeh, S.; Kamal, M. H.; Kurniawan, H.; Elsadawi, M.; Kenney, D.; Dhouam, F.; Bosmann, M.; Whelan, S.; Cabral, H.; Burks, E. J.; Zhao, G.; Kolachalama, V.; Ravid, K.; Chitalia, V.
10.1101/2025.01.17.633602 — systems biology — Posted on 2025-01-21
2122 A linked Genomics Sequencing and Mass Spectrometry multi-modal dataset and models for Streamlined Natural Products Discovery in Microbial Strain Libraries
Tay, D. W. P.; Koh, W.; Ang, S. J.; Wong, Z. M.; Lim, Y. W.; Heng, E.; Yeo, N. Z. X.; Adaikkappan, K.; Wong, F. T.; Lim, Y. H.
10.1101/2025.01.20.633932 — synthetic biology — Posted on 2025-01-21
2127 Multi-Region Brain Organoid: Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components
Kshirsagar, A.; Mnatsakanyan, H.; Kulkarni, S.; Guo, J.; Cheng, K.; Bohra, O.; Badr, C. E.; Kathuria, A.
10.1101/2025.01.20.633788 — bioengineering — Posted on 2025-01-21
2131 Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment
Miliordini, G.; Zacco, E.; Armaos, A.; Di Palma, F.; Masi, M.; Giloid, M.; Rupert, J.; Broglia, L.; Varignani, G.; Oneto, M.; Scotto, M.; Marotta, R.; GIROTTO, S.; Cavalli, A.; Tartaglia, G. G.
10.1101/2025.01.20.633558 — biochemistry — Posted on 2025-01-21
2137 GacA regulates symbiosis and mediates lifestyle transitions in Pseudomonas
Luo, Y.; Srinivas, A.; Guidry, C.; Bull, C.; Haney, C.; Hamilton, C. D.
10.1101/2025.01.20.633850 — microbiology — Posted on 2025-01-20
2141 SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals
Dadonaite, B.; Burrell, A. R.; Logue, J.; Chu, H. Y.; Payne, D. C.; Haslam, D. B.; Staat, M. A.; Bloom, J. D.
10.1101/2025.01.17.633612 — microbiology — Posted on 2025-01-20
2148 Role of N-glycosylation as a determinant of ATG9A conformations and activity
Lambrughi, M.; Utichi, M.; Borg, C. B.; Marjault, H.-B.; Echeverria, S. E.; Maeda, K.; Taylor, N. M. I.; Fadda, E.; Jaattela, M.; Papaleo, E.
10.1101/2025.01.17.633517 — biophysics — Posted on 2025-01-20
2150 Impact of selective digestive decontamination on the pangenome composition of ESBL-E. coli
Paganini, J. A.; Schurch, A. C.; Scharringa, J.; Bonten, M. J. M.; Willems, R. J. L.; Plantinga, N. L.
10.1101/2025.01.14.632990 — bioinformatics — Posted on 2025-01-20
2154 More cells, more doublets in highly multiplexed single-cell data
Howitt, G.; Dixit, G.; Aharon, R.; Streeton-Cook, V.; Ling, L.; Hickey, P. F.; Amann-Zalcenstein, D.; Gubbels, L.; Shanthikumar, S.; Ranganathan, S.; Neeland, M.; Maksimovic, J.; Oshlack, A.
10.1101/2024.10.03.616596 — bioinformatics — Posted on 2025-01-20
2155 Tunable porosity in a hydrogel with extreme vibration damping properties
Day, G. J.; Zhang, Q.; Remillat, C. D. L.; Comandini, G.; Perriman, A. W.; Scarpa, F.
10.1101/2025.01.16.633355 — bioengineering — Posted on 2025-01-20
2158 The Brugada syndrome associated gene WT1 impacts on SCN5A expression and cardiac conduction
Marsman, E. M. J.; Offerhaus, J. A.; Mengarelli, I.; Beekman, L.; Wilde, L. M.; Casini, S.; Goumans, M.-J.; Verkerk, A. O.; Jurgens, S. J.; Wilde, A. A.; Boukens, B. J.; Remme, C. A.; Bezzina, C. R.; Bosada, F. M.
10.1101/2025.01.16.633330 — genetics — Posted on 2025-01-20
2159 Evidence for evolution of a new sex chromosome within the Marchantiales haploid plant lineage
Fu, Y.; Zhang, X.; Zhang, T.; Sun, W.; Yang, W.; Shi, Y.; Zhang, J.; He, Q.; Charlesworth, D.; Jiao, Y.; Chen, Z.; Xu, B.
10.1101/2025.01.16.633329 — evolutionary biology — Posted on 2025-01-20
2160 H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
Oak, M. S.; Stock, M.; Mezes, M.; Straub, T.; Hynes-Allen, A. M.; van den Ameele, J.; Forne, I.; Ettinger, A.; Imhof, A.; Scialdone, A.; Hoermanseder, E. B.
10.1101/2025.01.20.633863 — developmental biology — Posted on 2025-01-20
2161 Mapping the complete influenza A virus infection cycle through single vRNP imaging
Rabouw, H. H.; Schokolowski, J.; Müller, M.; Baars, M. J.; Dost, A. F.; Bestebroer, T. M.; Püschel, J.; Clevers, H.; Fouchier, R.; Tanenbaum, M. E.
10.1101/2025.01.20.633851 — cell biology — Posted on 2025-01-20
2163 Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells
Moresco, P.; Kastan, J. P.; Yang, J.-I.; Prabakar, R.; Minicozzi, F.; Adams, D. W.; Cifani, P.; Tuveson, D. A.; Fearon, D. T.
10.1101/2025.01.18.633717 — cell biology — Posted on 2025-01-20
2167 Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate
Li, H.; Ji, S.; Ariefta, N. R.; Galon, E. M. S.; El-Sayed, S. A.; Do, T.; Jia, L.; Sakaguchi, M.; Asada, M.; Nishikawa, Y.; Qin, X.; Liu, M.; Xuan, X.
10.1101/2024.07.15.603500 — microbiology — Posted on 2025-01-20
2168 Regulating white blood cell activity through the novel Universal Receptive System
Tetz, G.; Kardava, K.; Vecherkovskaya, M.; Khodadadi-Jamayran, A.; Tsirigos, A.; Tetz, V.
10.1101/2025.01.06.631232 — immunology — Posted on 2025-01-20
2169 Embryonic macrophages in brown adipose tissue are spatially associated with developing nerves
Felix, I.; Ollikainen, J.; Haque, A.; Karhula, J.; Salmi, M.; Jokela, H.; Rantakari, P.
10.1101/2025.01.16.632922 — immunology — Posted on 2025-01-20
2170 The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling
Jones, A. E.; Rios, A.; Ibrahimovic, N.; Chavez, C.; Bayley, N. A.; Ball, A. B.; Hsieh, W. Y.; Sammarco, A.; Bianchi, A. R.; Cortez, A. A.; Graeber, T. G.; Hoffmann, A.; Bensinger, S. J.; Divakaruni, A. S.
10.1101/2024.03.28.587096 — immunology — Posted on 2025-01-20
2171 CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells
Meng, X.; Zhu, Y.; Liu, K.; Wang, Y.; Liu, X.; Liu, C.; Zeng, Y.; Wang, S.; Gao, X.; Shen, X.; Chen, J.; Tao, S.; Xu, Q.; Dong, L.; Shen, L.; Wang, L.
10.1101/2024.09.30.615805 — immunology — Posted on 2025-01-20
2172 A cholinergic spinal pathway for the adaptive control of breathing
Lin, M.; Calabrese, G. B.; Incognito, A. V.; Moore, M. T.; Agarwal, A.; Wilson, R. J. A.; Zagoraiou, L.; Sharples, S. A.; Miles, G. B.; Philippidou, P.
10.1101/2025.01.20.633641 — neuroscience — Posted on 2025-01-20
2177 Endothelial Sphingosine-1-Phosphate Receptor (S1PR) 1, a Functional S1PR in the Human Cerebrovascular Endothelium, Limits Blood Brain Barrier Permeability and Neuronal Injury following Subarachnoid Hemorrhage in Mice.
Ito, A.; Uchida, H.; Dash, S.; Aburakawa, D.; Shingai, Y.; Liu, C.; Avila Gomez, P.; Tominaga, K.; Kim, G. S.; Faraco, G.; Proia, R. L.; Niizuma, K.; Tominaga, T.; Anrather, J.; Iadecola, C.; Kluk, M. J.; Sanchez, T.
10.1101/2025.01.19.633813 — neuroscience — Posted on 2025-01-20
2178 The interplay between CB2 and NMDA receptors in Parkinsons disease
Lillo, J.; Raich, I.; Rebassa, J. B.; Capo, T.; Badia, P.; Navarro, G.; Reyes-Resina, I.
10.1101/2025.01.20.633878 — neuroscience — Posted on 2025-01-20
2179 The effects of task similarity during representation learning in brains and neural networks
Menghi, N.; Johnston, W. J.; Vigano', S.; Hinrichs, M. A. B.; Maess, B.; Fusi, S.; Doeller, C. F.
10.1101/2025.01.20.633896 — neuroscience — Posted on 2025-01-20
2180 Acute temporal, regional, and cell-type specific NKCC1 disruption following severe TBI in the developing gyrencephalic brain.
Hochstetler, A. E.; Courtney, Y.; Oloko, P.; Baskin, B.; Ding-Su, A.; Stinson, T.; McGuone, D.; Haynes, R.; Lehtinen, M. K.; Costine-Bartell, B. A.
10.1101/2025.01.20.633889 — neuroscience — Posted on 2025-01-20
2182 Using SED-ML for reproducible curation: Verifying BioModels across multiple simulation engines
Smith, L. P.; Malik-Sherif, R. S.; Nguyen, T. V. N.; Hermjakob, H.; Karr, J.; Shaikh, B.; Drescher, L.; Moraru, I. I.; Schaff, J.; Agmon, E.; Patrie, A.; Blinov, M. L.; Hellerstein, J.; May, E.; Nickerson, D.; Gennari, J.; Sauro, H.
10.1101/2025.01.16.633337 — systems biology — Posted on 2025-01-20
2183 Photosynthetic adjustments maintain lettuce growth under dynamically changing lighting in controlled indoor farming setups
Makinen, A.; Ishihara, H.; Poque, S.; Sipari, N.; Himanen, K.; Varjus, I.; Heininen, J.; Pastell, M.; Elomaa, P.; Shapiguzov, A.; Kotilainen, T.; Kangasjarvi, S.
10.1101/2025.01.16.633207 — plant biology — Posted on 2025-01-20
2184 Crop genotype modulates root rot resistance-associated microbial community composition and abundance of key taxa
Gfeller, V.; Schneider, M.; Bodenhausen, N.; Horton, M. W.; Wille, L.; Oldach, K. H.; Studer, B.; Hartmann, M.; Messmer, M. M.; Hohmann, P.
10.1101/2025.01.16.633298 — plant biology — Posted on 2025-01-20
2189 Detailed tandem repeat allele profiling in 1,027 long-read genomes reveals genome-wide patterns of pathogenicity
Danzi, M. C.; Xu, I. R. L.; Fazal, S.; Dolzhenko, E.; Pellerin, D.; Weisburd, B.; Reuter, C.; Sampson, J.; Folland, C.; Wheeler, M. T.; O'Donnell-Luria, A.; Wuchty, S.; Ravenscroft, G.; Eberle, M. A.; All of Us Research Program Long Read Working Group, ; Zuchner, S.
10.1101/2025.01.06.631535 — genomics — Posted on 2025-01-20
2191 Transcription Factors DksA and PsrA are synergistic contributors to L. pneumophila virulence in Acanthamoeba castellanii protozoa
Graham, C. I.; Gierys, A. J.; MacMartin, T. L.; Penner, T. V.; Beck, J. C.; Prehna, G.; de Kievit, T. R.; Brassinga, A. K. C.
10.1101/2024.07.09.602712 — microbiology — Posted on 2025-01-20
2192 Fusobacterium nucleatum determines the expression of amphetamine-induced behavioral responses through an epigenetic phenomenon.
Mabry, S. J.; Cao, X.; Zhu, Y.; Rowe, C. S.; Patel, S.; Gonzalez-Arancibia, C.; Romanazzi, T.; Saleeby, D.; Elam, A.; Lee, H.-T.; Turkmen, S.; Lauzon, S. N.; Hernandez, C. E.; Sun, H.; Wu, H.; Carter, A. M.; Galli, A.
10.1101/2025.01.15.633210 — neuroscience — Posted on 2025-01-20
2195 Optical imaging of treatment-naive human NSCLC reveals changes associated with metastatic recurrence
Diaz, P. M.; Ivers, J. D.; Byrum, S. D.; Quick, C. M.; Arnaoutakis, K.; Quinn, K. P.; Rajaram, N.
10.1101/2024.10.14.618213 — cancer biology — Posted on 2025-01-20
2197 Molecular Dynamics Study of α-Synuclein Domain Deletion Mutant Monomers
Onishi, N.; Mazzaferro, N.; Kunstelj, S.; Alvarado, D.; Muller, A.; Vazquez, F. X.
10.1101/2024.03.23.586267 — biophysics — Posted on 2025-01-20
2198 Biomolecular Condensates Can Enhance Homotypic RNA Clustering
Mahendran, T. S.; Wadsworth, G. M.; Singh, A.; Gupta, R.; Banerjee, P. R.
10.1101/2024.06.11.598371 — biophysics — Posted on 2025-01-20
2199 GPU-accelerated homology search with MMseqs2
Kallenborn, F.; Chacon, A.; Hundt, C.; Sirelkhatim, H.; Didi, K.; Cha, S.; Dallago, C.; Mirdita, M.; Schmidt, B.; Steinegger, M.
10.1101/2024.11.13.623350 — bioinformatics — Posted on 2025-01-20
2202 Neuroligin 3 highlights sexually dimorphic circuitry in Drosophila social spacing
Robinson, J. W.; Bechard, A. T.; Evans, M. R.; Mosuro, K.; Isaacson, J. R.; Pillay, S.; Lin, D. S.; Sahota, A.; de Belle, J. N.; Robinson, G. I.; Simon, A. F.
10.1101/2024.10.28.620699 — animal behavior and cognition — Posted on 2025-01-20
2203 Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations
Inchausti, L.; Bilbao, L.; Campo, V. A.; Garat, J.; Sotelo-Silveira, J.; Rinaldi, G.; Howick, V. M.; Duhagon, M. A.; G. De Gaudenzi, J.; Smircich, P.
10.1101/2025.01.14.633000 — genomics — Posted on 2025-01-20
2204 Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever
Srour, S.; ElGhazaly, M.; O'Connor, D.; Gibani, M. M.; Darton, T. C.; Pollard, A. J.; Collins, M. O.; Humphreys, D.
10.1101/2024.12.13.628371 — microbiology — Posted on 2025-01-20
2205 Dilated cardiomyopathy-associated RNA Binding Motif Protein 20 regulates long pre-mRNAs in neurons
Di Bartolomei, G.; Ortiz, R.; Schreiner, D.; Falkner, S.; Creemers, E. E.; Scheiffele, P.
10.1101/2023.12.06.570345 — neuroscience — Posted on 2025-01-20
2207 Conditioning electrical stimulation fails to enhance sympathetic axon regeneration
Tian, T.; Patel, K.; Kim, D.; SiMa, H.; Harris, A.; Owyoung, J.; Ward, P. J.
10.1101/2023.02.03.527071 — neuroscience — Posted on 2025-01-20
2208 Pain distribution can be determined by classical conditioning
Nastaj, J.; Skalski, J.; Nowak, D.; Kruszyna, N.; Babel, P.; Szikszay, T.; Luedtke, K.; Gnat, R.; Adamczyk, W. M.
10.1101/2024.08.31.609921 — physiology — Posted on 2025-01-20
2209 FlowDesign: Improved Design of Antibody CDRs Through Flow Matching and Better Prior Distributions
Wu, J.; Kong, X.; Sun, N.; Wei, J.; Shan, S.; Feng, F.; Wu, F.; Peng, J.; Zhang, L.; Liu, Y.; Ma, J.
10.1101/2024.11.07.622422 — bioinformatics — Posted on 2025-01-20
2216 CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells
Meng, X.; Zhu, Y.; Liu, K.; Wang, Y.; Liu, X.; Liu, C.; Zeng, Y.; Wang, S.; Gao, X.; Shen, X.; Chen, J.; Tao, S.; Xu, Q.; Dong, L.; Shen, L.; Wang, L.
10.1101/2024.09.30.615805 — immunology — Posted on 2025-01-20
2217 Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi
Stuchly, J.; Novak, D.; Brdickova, N.; Hadlova, P.; Sadilek, V.; Iksi, A.; Kuzilkova, D.; Svaton, M.; Saad, G. A.; Engel, P.; Luche, H.; Sousa, A. E.; Almeida, A. R. M.; Kalina, T.
10.1101/2023.07.13.547329 — immunology — Posted on 2025-01-20
2218 Shaping the physical world to our ends: The left PF technical-cognition area
Osiurak, F.; Federico, G.; Fournel, A.; Gaujoux, V.; Lamberton, F.; Ibarrola, D.; Rossetti, Y.; Lesourd, M.
10.1101/2024.01.02.573935 — neuroscience — Posted on 2025-01-20
2219 A General Framework for Characterizing Optimal Communication in Brain Networks
Fakhar, K.; Hadaeghi, F.; Seguin, C.; Dixit, S.; Messe, A.; Zamora-Lopez, G.; Misic, B.; Hilgetag, C.
10.1101/2024.06.12.598676 — neuroscience — Posted on 2025-01-20
2220 Disruption of G3BP1 Granules Promotes Mammalian CNS and PNS Axon Regeneration
Sahoo, P. K.; Agrawal, M. A.; Hanovice, N.; Ward, P.; Desai, M.; Smith, T. P.; SiMa, H.; Dulin, J. N.; Vaughn, L. S.; Tuszynski, M.; Welshhans, K.; Benowitz, L.; English, A.; Houle, J. D.; Twiss, J. L.
10.1101/2024.06.07.597743 — neuroscience — Posted on 2025-01-20
2225 Long-range organization of primary intestinal fibroblasts guides directed and persistent migration of organoid-derived intestinal epithelia
Fernandez-Majada, V.; Comelles, J.; Abad-Lazaro, A.; Acevedo, V.; Esteve-Codina, A.; Hernando-Momblona, X.; Batlle, E.; Martinez, E.
10.1101/2021.05.28.446131 — cell biology — Posted on 2025-01-20
2226 Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation
Roy, T.; Ghosh, S.; Piplani, N.; Sthanam, L. K.; Tiwary, N.; Dhar, S.; Konyak, W. C. W.; Panigrahi, S. S.; Singh, P.; Sowpati, D. T.; Nair, S.; Kumar, S.; Shekar, P. C.; Sen, S.
10.1101/2024.03.15.585216 — cell biology — Posted on 2025-01-20
2229 TMPRSS2-ERG confers resistance to antiandrogens: mechanism and therapeutic implications
Sekar, A.; Chatterjee, R.; Selvadurai, B. R.; Ray, L.; Verma, A.; Nataraj, N. B.; Garcia, D. D.; Giri, S.; Genna, A.; Karatekin, F.; Gupta, N.; Zerbib, M.; Vinik, Y.; Avioz, T.; Weizman, E.; David, E.; A. Schaffer, A.; Pan, Y.; Huang, H.; M van Weerden, W.; Corey, E.; Hunt, H.; Greenstein, A.; Blecher-Gonen, R.; Oren, R.; Afek, A.; Amit, I.; Lev, S.; Ku, A.; Kartal, S.; R. Bright, J.; T. Lis, R.; L. Dahut, W.; Sowalsky, A. G.; Ruppin, E.; Yarden, Y.
10.1101/2025.01.17.633582 — cancer biology — Posted on 2025-01-20
2230 HPV integration in head and neck cancer: downstream splicing events and expression ratios linked with poor outcomes
Li, S.; Xia, S.; Lawas, M.; Kulshreshtha, A.; Garb, B. F.; Perera, C.; Li, C.; Qin, T.; Welch, J. D.; DSilva, N. J.; Rozek, L. S.; Sartor, M. A.
10.1101/2025.01.17.633627 — cancer biology — Posted on 2025-01-20
2231 SPARC is a new driver of early breast tumor progression via TGF-β -dependent mechanism.
Sciacca, M.; Carballo, M. d. P.; Lacunza, E.; Marino, L.; Cardozo, P. N.; Rodriguez Padilla, N.; Lopez-Lopez, T.; Abba, M.; Courtois, L.; Bieche, I.; Vincent-Salomon, A.; Bilbao, E. R.; Podsypanina, K.; Boissan, M.; Chavrier, P.; Eijan, A. M.; Saez, P. J.; Lodillinsky, C.
10.1101/2025.01.17.632337 — cancer biology — Posted on 2025-01-20
2233 Recommendations for Automating Hydrogen/Deuterium Exchange Mass Spectrometry Measurements using Data-Independent Acquisition Methods
Filandr, F.; Hepburn, M.; Sarpe, V.; Crowder, D. A.; Hassannia, M.; Coales, S.; Shi, Y.; Viner, R.; Rossotti, M. A.; Sheff, J. G.; Tanha, J.; Schriemer, D. C.
10.1101/2025.01.18.633743 — biochemistry — Posted on 2025-01-20
2235 Infected host competence overshadows heterogeneity in susceptibility in shaping experimental epizootics
Perez-Umphrey, A.; Langwig, K.; Adelman, J.; Childs, L.; Garrett-Larsen, J.; Hawley, D. M.; Fleming-Davies, A.
10.1101/2025.01.15.632224 — ecology — Posted on 2025-01-20
2238 Competition for light color between marine Synechococcus strains with fixed and variable pigmentation
Dufour, L.; Garczarek, L.; Mattei, F.; Gouriou, B.; Clairet, J.; Ratin, M.; Kehoe, D. M.; Huisman, J.; Verspagen, J.; Partensky, F.
10.1101/2025.01.17.633661 — microbiology — Posted on 2025-01-20
2239 HoloMoA: Fast holography and deep-learning-based tool for the novelty detection of mechanism of action of antimicrobial candidates
Sedaghat, Z.; Courbon, B.; Botrel, H.; Dugua, H.; Tulinski, P.; Alibaud, L.; Pagani, L.; Mercer, D. K.; Guyard, C.; Vedrine, C.; Dixneuf, S.
10.1101/2025.01.17.633645 — microbiology — Posted on 2025-01-20
2240 Validation and multi-site deployment of a lyophilized qRT-PCR reagent for the molecular diagnosis of avian influenza and rabies in Sub-Saharan African regions
Drzewniokova, P.; Brian, I.; Mancin, M.; Fortin, A.; Gourlaouen, M.; Angot, A.; Niang, M.; Dah, I.; Berete, K.; Diakite, A.; Lo, F. T.; Meseko, C.; Go-Maro, E.; D'Amico, V.; Valastro, V.; Soumare, B.; De Benedictis, P.; Monne, I.; Panzarin, V.
10.1101/2025.01.16.633398 — microbiology — Posted on 2025-01-20
2242 Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity
Jamieson, P. J.; Shen, X.; Abu-Shmais, A. A.; Wasdin, P. T.; Janowska, K.; Edwards, R. J.; Scapellato, G.; Richardson, S. I.; Manamela, N. P.; Liu, S.; Barr, M.; Gillespie, R. A.; Mimms, J.; Suryadevara, N.; Sornberger, T. A.; Zost, S.; Parks, R.; Flaherty, S.; Janke, A. K.; Howard, B. N.; Suresh, Y. P.; Ruprecht, R. M.; Crowe, J. E.; Carnahan, R. H.; Bailey, J. R.; Masaru, K.; Haynes, B. F.; Moore, P. L.; Acharya, P.; Montefiori, D. C.; Kalams, S. A.; Lu, S.; Georgiev, I. S.
10.1101/2025.01.17.633475 — immunology — Posted on 2025-01-20
2243 Autoantibody hotspots reveal origin and impact of immunogenic XIST ribonucleoprotein complex
Yan, B.; Lee, J.; Srinivasan, S.; Shi, Q.; Dou, D. R.; Davuluri, S.; Nandyala, S.; Woods, A.; Leatherman, G.; Zhao, Y.; Reggiardo, R. E.; Sawant, M.; Thiam, H. R.; Shah, A. A.; Fiorentino, D. F.; Chung, L. S.; Chang, H. Y.
10.1101/2025.01.16.633465 — immunology — Posted on 2025-01-20
2245 Detection of Diffuse to Focal Myocardial Fibrosis by Cardiovascular Magnetic Resonance Against Histology in Mini-Swine
Zhang, H.; Cui, C.; Yang, W.; Zhou, D.; Wang, Y.; Zhu, L.; Jiang, M.; Zhang, Q.; Zhao, S.; Piechnik, S. K.; Ferreira, V. M.; Lu, M.
10.1101/2025.01.13.632871 — pathology — Posted on 2025-01-20
2246 Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages
Fei, H.; Lu, X.; Shi, Z.; Liu, X.; Yang, C.; Zhu, X.; Lin, Y.; Jiang, Z.; Wang, J.; Huang, D.; Liu, L.; Zhang, S.; Jiang, L.
10.1101/2024.06.05.597577 — immunology — Posted on 2025-01-20
2247 Fluorogenic Interacting Protein Stabilization for Orthogonal RNA Imaging
Zhou, W.-J.; Wu, M.-Y.; Shao, X.-J.; Tang, L.-J.; Wang, F.; Jiang, J.-H.
10.1101/2025.01.17.633511 — cell biology — Posted on 2025-01-20
2248 Genotype-specific roles of small extracellular vesicles in modulating metronidazole resistance in Giardia lamblia
Luna Pizarro, G.; Laiolo, J.; Salas, N.; Patolsky, R. G.; Diaz Perez, L.; Cotello, C.; Feliziani, C.; Ropolo, A. S.; TOUZ, M. C.
10.1101/2025.01.17.633589 — cell biology — Posted on 2025-01-20
2249 Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential
Rossignoli, G.; Oberhuemer, M.; Brun, I. S.; Zorzan, I.; Osnato, A.; Wenzel, A.; van Genderen, E.; Drusin, A.; Panebianco, G.; Magri, N.; Solis, M. A.; Colantuono, C.; van Knippenberg, S. S. F. A.; Pham, T. X. A.; Khodeer, S.; Grumati, P.; Cacchiarelli, D.; Martini, P.; Rivron, N. C.; Pasque, V.; Zylicz, J. J.; Leeb, M.; Martello, G.
10.1101/2025.01.17.633522 — cell biology — Posted on 2025-01-20
2250 Plakophilin-2 Coordinates Energy Metabolism and Contractility in Cardiomyocytes, Revealing Its Roles beyond Desmosomes
Aycinena, J. A.; Tefera, A. E.; Perea-Gil, I.; Holbrook-Smith, D.; Williams, K. J.; Shenwai, R. J.; Farshidfar, F.; Ryback, B. M.; Foppe, K.; Wu, I.; Zeng, A.; Van Pell, M.; Xu, E. Y.; Woods, J.; Jones, S.; Hatter, Y. D.; Dee-Hoskins, C.; Madariaga, J.; Robinson, K.; Greer-Short, A.; Song, X.; Ivey, K. N.; Priest, J.; Argast, G.; Hoey, T.; Driggers, E. M.; Yang, Z.
10.1101/2025.01.17.633239 — cell biology — Posted on 2025-01-20
2251 Constitutive expression of cardiomyocyte Klf9 precipitates metabolic dysfunction and spontaneous heart failure.
Thakkar, C.; Alikunju, S.; Venkatasubramanian, A.; Yang, Z.; Sayed, N.; Abdellatif, M.; Sayed, D.
10.1101/2025.01.16.633464 — cell biology — Posted on 2025-01-20
2252 The liver clock tunes transcriptional rhythms in skeletal muscle to regulate mitochondrial function
Sica, V.; Sato, T.; Tsialtas, I.; Hernandez, S.; Chen, S.; Baldi, P.; Munoz-Canoves, P.; Sassone-Corsi, P.; Koronowski, K. B.; Smith, J. G.
10.1101/2025.01.17.633623 — cell biology — Posted on 2025-01-20
2253 Oligodendroglia vulnerability in the human dorsal striatum in Parkinson's disease
Reyes, J. M. B.; Harder, L.; Salas, S. M.; Jaisa-aad, M.; Castro, C. M.; Rafati, N.; Nilsson, M.; Hyman, B.; Pozo, A. S.; Munoz-Manchado, A. B.
10.1101/2025.01.15.633167 — neuroscience — Posted on 2025-01-20
2259 Histone deacetylase-1 is required for epigenome stability in Neurospora crassa
Ebot-Ojong, F.; Ferraro, A. R.; Kaddar, F.; Hull-Crew, C.; Scadden, A. W.; Klocko, A. D.; Lewis, Z. A.
10.1101/2025.01.17.633486 — genetics — Posted on 2025-01-20
2261 Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency
Zhao, R.; Wivagg, A.; Lackner, R. M.; Salsman, J.; Dellaire, G.; Matunis, M. J.; Chenoweth, D. M.; Zhao, X.; Zhang, H.
10.1101/2025.01.16.633463 — cell biology — Posted on 2025-01-20
2264 Hsp70 chaperones, Ssa1 and Ssa2, limit poly(A) binding protein aggregation
Buchholz, H. E.; Martin, S. A.; Dorweiler, J. E.; Radtke, C. M.; Knier, A. S.; Beans, N. B.; Manogaran, A. L.
10.1101/2025.01.17.633617 — cell biology — Posted on 2025-01-20
2266 The Innexin 7 gap junction protein contributes to synchronized activity in the Drosophila antennal lobe and regulates olfactory function
Fuenzalida-Uribe, N.; Hidalgo, S.; Silva, B.; Gandhi, S.; Vo, D.; Zamani, P.; Holmes, T. C.; Sayin, S.; Kadow, I. C. G.; Hadjieconomou, D.; O'Dowd, D. K.; Campusano, J. M.
10.1101/2025.01.19.633780 — neuroscience — Posted on 2025-01-20
2269 Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing
Li, J.; Wang, Q.; Zhou, Q.; Yang, L.; Shen, Y.; Huang, S.; Wang, S.; Pylkkänen, L.; Huang, Z.
10.1101/2024.06.20.599315 — neuroscience — Posted on 2025-01-20
2270 Combining SMN2 splicing modifiers with HDAC6 inhibition greatly improves muscle function and survival in Spinal Muscular Atrophy
Osseni, A.; Slika, R.; Coudert, L.; Conjard-Duplany, A.; Weill, L.; Belotti, E.; Clerc, Z.; Gangloff, Y. g.; Sapaly, D.; Vuillerot, C.; Leblanc, P.; Charbonnier, F.; Schaeffer, L.
10.1101/2025.01.15.633267 — physiology — Posted on 2025-01-20
2271 Age and Sex-Specific Changes in Mitochondrial Quality Control in Skeletal and Cardiac Muscle
Springer-Sapp, C. B.; Ogbara, O.; Canellas da Silva, M.; Liu, Y.; Prior, S. J.; Kuzmiak-Glancy, S.
10.1101/2025.01.15.633257 — physiology — Posted on 2025-01-20
2272 TUB-010, a novel anti-CD30 antibody-drug conjugate based on Tub-tag technology, widens the therapeutic window by reducing toxicity while maintaining high efficacy
Gerlach, M.; Schmitt, S.; Cyprys, P.; Kasper, M.-A.; Mai, I.; Klanova, M.; Maiser, A.; Leonhardt, H.; Hackenberger, C. P. R.; Fingerle-Rowson, G. R.; Vogl, A. M.; Schumacher, D.; Helma-Smets, J.
10.1101/2025.01.15.633119 — cancer biology — Posted on 2025-01-19
2273 Engineered spermidine-secreting Saccharomyces boulardii ameliorate colitis and colon cancer in mice
Liu, J.; Mohaqiq, M.; Palou, R.; Li, R.; Zhang, G.; Vaishnav, H.; Parweez, F.; Moyana, T.; Carragher, D.; Cameron, D. W.; Ramsay, T.; van der Sloot, A.; Murthy, S.; Coombes, B.; Tyers, M.
10.1101/2025.01.19.633601 — cancer biology — Posted on 2025-01-19
2275 Tumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancer
Adler, K. M.; Xu, H.; Gladstein, A. C.; Irizarry-Negron, V. M.; Robertson, M. R.; Doerig, K. R.; Petrov, D. A.; Winslow, M. M.; Feldser, D. M.
10.1101/2025.01.15.633175 — cancer biology — Posted on 2025-01-19
2277 PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma
Paras, K.; Brunner, J.; Boyer, J. A.; Montero, A.; Jackson, B.; Chakraborty, S.; Xie, A.; Guillan, K.; Siddiquee, A.; Torres, L. P.; Rabinowitz, J.; Kung, A. L.; Dela Cruz, F. S.; Finley, L.
10.1101/2025.01.15.633227 — cancer biology — Posted on 2025-01-19
2278 The MYCN/Aurora-A complex is a cyclin activating kinase for CDK12
Mueller, M.; Eing, L.; Uhl, L.; Schmitz, M.; Kaneva, I.; Byrne, D. P.; Fleischhauer, D.; Burgess, S. G.; Fischer, S.; Gebauer, N.; Nancy-Portebois, V.; Kaltheuner, I. H.; Ha, S. A.; Schuelein-Voelk, C.; Solvie, D.; Richards, M. W.; Vidal, R.; Brand, M.; Papadopoulos, D.; Bayliss, R. W.; Eyers, P. A.; Eyers, C. E.; Geyer, M.; Eilers, M.; Buechel, G.
10.1101/2025.01.15.633177 — cancer biology — Posted on 2025-01-19
2280 Bidirectional communication between nucleotide and substrate binding sites in a type IV multidrug ABC transporter
Perez Carrillo, V. H.; Di Cesare, M.; Rose-Sperling, D.; Javeed, W.; Neuweiler, H.; Marcoux, J.; Orelle, C.; Jault, J.-M.; Hellmich, U. A.
10.1101/2025.01.15.633140 — biophysics — Posted on 2025-01-19
2281 Run-and-tumble dynamics of E. coli is governed by its mechanical properties
Wu-Zhang, B.; Zhang, P.; Baillou, R.; Lindner, A.; Clement, E.; Gompper, G.; Fedosov, D.
10.1101/2025.01.15.633156 — biophysics — Posted on 2025-01-19
2282 The mechanism of DRB7.2:DRB4 mediated sequestering of endogenous inverted-repeat dsRNA precursors in plants
Paturi, S.; Patra, D.; Behera, P. C.; Aute, R.; Waghela, N.; Kinatukara, P.; Deshmukh, M. V.
10.1101/2025.01.15.633165 — biophysics — Posted on 2025-01-19
2284 Single-cell morphological profiling reveals insights into cell death
Frey, B.; Holmberg, D.; Bystrom, P.; Bergman, E.; Georgiev, P.; Johansson, M. M.; Hennig, P.; Rietdijk, J.; Rosen, D.; Carreras-Puigvert, J.; Spjuth, O.
10.1101/2025.01.15.633042 — bioinformatics — Posted on 2025-01-19
2285 CroCoDeEL: accurate control-free detection of cross-sample contamination in metagenomic data
Goulet, L.; Onate, F. P.; Famechon, A.; Quinquis, B.; Belda, E.; Prifti, E.; Le Chatelier, E.; Gautreau, G.
10.1101/2025.01.15.633153 — bioinformatics — Posted on 2025-01-19
2287 JIND-Multi: Leveraging Multiple Labeled Datasets for Automated Annotation of Single-Cell RNA and ATAC Data
Sancho Zamora, J.; Kanhirodan, A.; Garrote, X.; Gevaert, O.; Hernaez, M.; Serrano, G.; Ochoa, I.
10.1101/2025.01.15.633130 — bioinformatics — Posted on 2025-01-19
2288 CARDBiomedBench: A Benchmark for Evaluating Large Language Model Performance in Biomedical Research
Bianchi, O.; Willey, M.; Avarado, C. X.; Danek, B.; Khani, M.; Kuznetsov, N.; Dadu, A.; Shah, S.; Koretsky, M. J.; Makarious, M. B.; Weller, C.; Levine, K. S.; Kim, S.; Jarreau, P.; Vitale, D.; Marsan, E.; Iwaki, H.; Leonard, H.; Bandres-Ciga, S.; Singleton, A. B.; Nalls, M. A.; Mokhtari, S.; Khashabi, D.; Faghri, F.
10.1101/2025.01.15.633272 — bioinformatics — Posted on 2025-01-19
2295 On the biodegradation of micropatterned polymeric film
Guerriero, I.; Pesce, C.; Spano, R.; Sganga, S.; Tirelli, N.; Di Mascolo, D.; Palange, A. L.; Decuzzi, P.
10.1101/2025.01.15.633178 — bioengineering — Posted on 2025-01-19
2301 3D-Printed Magnetic Levitation Device with Deep Learning-Assisted Particle Tracking and Analysis for High-Throughput Sorting
Ramarao, M.; Ozaltin, A.; Yaman, S.; Ozbozduman, K.; Loc, I.; Ertok, N.; Gao, A.; Unlu, M. B.; Durmus, N. G.
10.1101/2025.01.15.633098 — bioengineering — Posted on 2025-01-20
2302 Target-based de novo design of cyclic peptide binders
Wang, F.; Zhang, T.; Zhu, J.; Zhang, X.; Zhang, C.; Lai, L.
10.1101/2025.01.18.633746 — biochemistry — Posted on 2025-01-19
2303 Allosteric factors in the calcium/calmodulin-responsive kinase II hub domain determine selectivity of GHB ligands for CaMKIIa
Gauger, S. J.; Palmelund, L. B.; Tian, Y.; Marek, A.; Namini, M. R.; Griem-Krey, N.; Kickinger, S.; Mortensen, J. S.; Frolund, B.; Wellendorph, P.
10.1101/2025.01.19.633782 — biochemistry — Posted on 2025-01-19
2304 A Screening Approach Unveils an Unknown Mn2+ - dependent Endopolyphosphatase Activity in Yeast
Moser, S.; Hans, G.; Saiardi, A.; Bru, S.; Taskin, A.; Meisinger, C.; Jessen, H. J.
10.1101/2025.01.19.633793 — biochemistry — Posted on 2025-01-19
2305 Mechanistic Elucidation of CLIC1 Membrane Insertion via Structural and Dynamic Modulation
Cassar, J.; Serrano-Sanchez, A.; Bragg, J.; Medina-Carmona, E.; Ossa, F.; Thompson, G. S.; Abdul-Salam, V. B.; Varela, L.; Ortega-Roldan, J. L.
10.1101/2025.01.19.633805 — biochemistry — Posted on 2025-01-19
2306 Engineering a highly selective, hemoprotein-based scavenger as a carbon monoxide poisoning antidote with no hypertensive effect
Dent, M. R.; DeMartino, A. W.; Xu, Q.; Chen, X.; Ghandi, A.; Hwang, J.; Bocian, K. A.; Alipour, E.; Ucer, B.; Baker, S. R.; Srimath Kandada, A. R.; Bulbul, A.; Kim-Shapiro, D. B.; Rose, J. J.; Tejero, J.; Gladwin, M. T.
10.1101/2025.01.18.633417 — biochemistry — Posted on 2025-01-19
2308 Land-use change undermines the stability of avian functional diversity
Weeks, T. L.; Walkden, P. A.; Edwards, D. P.; Lees, A. C.; Pigot, A. L.; Purvis, A.; Tobias, J.
10.1101/2025.01.15.633202 — ecology — Posted on 2025-01-19
2313 Lack of RNase HI affects virulence in Salmonella enterica
Jimenez-Espadafor, J.; Ortiz-Padilla, M.; Pedraza-Delgado, D. A.; Bernal-Bayard, J.; Ramos-Morales, F.; Balbontin, R.
10.1101/2025.01.19.633779 — microbiology — Posted on 2025-01-19
2317 IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion
Aldridge, D. L.; Lanzar, Z.; Phan, A.; Christian, D. A.; Pardy, R.; Min, B.; Kedl, R.; Hunter, C.
10.1101/2025.01.15.633135 — immunology — Posted on 2025-01-19
2318 Myositis-specific autoantibodies recognizing Mi2 also target the autoimmune regulator (AIRE) protein at a shared PHD-zinc finger
Musai, J.; Jayaraman, S.; Pak, K.; Pinal-Fernandez, I.; Munoz-Braceras, S.; Casal-Dominguez, M.; Cho, E.; Fitisemanu, F. M.; Burbelo, P. D.; Kaplan, M. J.; Warner, B. M.; Schiffenbauer, A. I.; Selva-O'Callaghan, A.; Milisenda, J. C.; Rider, L. G.; Larman, H. B.; Mammen, A. L.
10.1101/2025.01.15.633218 — immunology — Posted on 2025-01-19
2319 Targeted Antisense Oligonucleotide Treatment Rescues Developmental Alterations in Spinal Muscular Atrophy Organoids
Faravelli, I.; Rinchetti, P.; Tambalo, M.; Simutin, I.; Mapelli, L.; Mancinelli, S.; Miotto, M.; Rizzuti, M.; D'Angelo, A.; Cordiglieri, C.; Forotti, G.; Peano, C.; Kunderfranco, P.; Calandriello, L.; Comi, G. P.; Paraboschi, E.; Pali, E.; Beatrice, F.; D'Angelo, E.; Przedborski, S.; Nizzardo, M.; Lodato, S.; Corti, S.
10.1101/2025.01.17.633436 — neuroscience — Posted on 2025-01-19
2320 7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in Alzheimer's disease
Radhakrishnan, K.; Zhang, Y.; Mustapha, O.; Weigel, T. K.; Upchurch, C.; Tian, X.; Herbert, F.; Huang, W.; Leitinger, N.; Eyo, U. B.; Ai, H.; Ferris, H. A.
10.1101/2025.01.19.633810 — neuroscience — Posted on 2025-01-19
2321 NAc-DBS selectively enhances memory updating without effect on retrieval
Perez-Segura, A.; Medina, J.; Cerdan Cerda, A.; Sanchez-Ferri, C.; Torres, D.; Mirasso, C. R.; Strange, B.; Eguiluz, V. M.; Lacasa, L.; Canals, S.
10.1101/2025.01.16.633319 — neuroscience — Posted on 2025-01-19
2323 Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use
Davis, O. C.; Ferland, S.; Lorenzo, L.-E.; Murray-Lawson, C.; Shiers, S.; Yousuf, M. S.; Dedek, A.; Tsai, E. C.; Vines, E.; Horton, P.; Cervantes, A.; Khan, T.; Funk, G.; Dussor, G.; Godin, A. G.; Ferrini, F.; De Koninck, Y.; Hildebrand, M. E.; Price, T. J.
10.1101/2025.01.19.633733 — neuroscience — Posted on 2025-01-19
2325 Disrupted α-ketoglutarate homeostasis trains monocyte-derived macrophages towards M2-like phenotype in long-term treated HIV-infection
Escos, A.; Ambikan, A.; Schuster, S.; Svensson-Akusjärvi, S.; Gelpi, M.; Mansouri, S.; Naval, P.; Junior, R. L.; Sood, V.; Knudsen, A. D.; Pathade, P. P.; Mikaeloff, F.; Hogh, J.; Lourda, M.; Vesterbacka, J.; Nowak, P.; Benfield, T.; Pawar, V.; Siegfried, W.; Muvva, J. R.; Vegvari, A.; Gupta, S.; Savai, R.; Poulsen, S. D.; Neogi, U.
10.1101/2025.01.15.633214 — systems biology — Posted on 2025-01-19
2326 Gene syntax defines supercoiling-mediated transcriptional feedback
Johnstone, C. P.; Love, K. S.; Kabaria, S. R.; Jones, R. D.; Blanch-Asensio, A.; Ploessl, D. S.; Peterman, E. L.; Lee, R.; Yun, J.; Oakes, C. G.; Mummery, C. L.; Davis, R. P.; DeKosky, B. J.; Zandstra, P. W.; Galloway, K. E.
10.1101/2025.01.19.633652 — synthetic biology — Posted on 2025-01-19
2327 Blood-borne sphingosine 1-phosphate maintains vascular resistance and cardiac function.
Del Gaudio, I.; Bonnin, P.; Roy-Vessiers, E.; Robidel, E.; Garcia, M.; Proux, C.; Boutigny, A.; Baudrie, V.; Ha, T. T. H.; Couty, L.; Faedda, N.; Mebrek, N.; Morel, T.; Nitzsche, A.; Baron, S.; Lenoir, O.; Tharaux, P.-L.; Zennaro, M.-C.; Nguyen, L. N.; Henrion, D.; Camerer, E.
10.1101/2025.01.15.633211 — physiology — Posted on 2025-01-19
2330 Mechanistic Insights into Sphingomyelin Nanoemulsions as Drug Delivery Systems for Non-Small Cell Lung Cancer Therapy
Ramos Docampo, E.; Garcia-Fernandez, J.; Marmol, I.; Morin-Jimenez, I.; Iglesias Baleato, M.; de la Fuente Freire, M.
10.1101/2025.01.15.633158 — pharmacology and toxicology — Posted on 2025-01-19
2331 In vitro Activity of Citrus IntegroPectin against Lung Cancer Cells
Di Sano, C.; D'Anna, C.; Li Petri, G.; Angellotti, G.; Meneguzzo, F.; Pagliaro, M.; Ciriminna, R.
10.1101/2025.01.15.633201 — pharmacology and toxicology — Posted on 2025-01-19
2336 Single cell resolved spatial immune repertoire unveils spatial heterogeneity of lymphoid aggregates in human immune disorders
Zhan, X.; Liu, Y.; Guo, Y.; Zhou, W.; Yan, Y.; Zeng, H.; Dong, X.; Chen, X.; Ma, R.; Liu, Z.; Zhu, F.; Zheng, X.; Li, X.; Yin, J.; Chan, F. K.-m.; Liu, C.; Liu, L.; Xu, X.; Hou, Y.; Tao, H.; Dong, Y.; Zeng, T.; Li, Y.; Zhou, J.; Zeng, Z.; Feng, Y.
10.1101/2025.01.16.630222 — immunology — Posted on 2025-01-19
2340 Video based phenotyping platform for the laboratory mouse
Choudhary, A.; Geuther, B. Q.; Beane, G.; Sproule, T. J.; Choudhary, A.; Trapszo, J.; Hession, L.; Kohar, V.; Kumar, V.
10.1101/2022.01.13.476229 — animal behavior and cognition — Posted on 2025-01-19
2341 Dominance reversal maintains large-effect resistance polymorphism in temporally varying environments
Karageorgi, M.; Lyulina, A. S.; Bitter, M. C.; Lappo, E.; Greenblum, S. I.; Mouza, Z. K.; Tran, C. T.; Huynh, A. V.; Oken, H.; Schmidt, P.; Petrov, D. A.
10.1101/2024.10.23.619953 — evolutionary biology — Posted on 2025-01-19
2342 Persistent interferon signaling that causes sensory neuron plasticity and pain in arthritis
Su, J.; Zhang, M.; Kupari, J.; Kwak, D.; Picton, L.; Xu, B.; Hu, Y.; Gonzalez, A.; Usoskin, D.; Xu, Z.; Manira, A. E.; Holmdahl, R.; Ernfors, P.
10.1101/2025.01.18.633447 — neuroscience — Posted on 2025-01-19
2346 Transcriptional and synaptic regulation of NMDA glutamate receptor-mediated hippocampal plasticity and memory
Parra-Damas, A.; del Ser-Badia, A.; Fernandez-Olalla, X.; Deprada-Fernandez, A.; Enriquez-Barreto, L.; Mengual, J. P.; Catala-Solsona, J.; Brito, V.; Rodriguez-Alvarez, J.; Gines, S.; Rodriguez-Moreno, A.; Saura, C. A.
10.1101/2025.01.19.633774 — neuroscience — Posted on 2025-01-19
2347 Shared and individual tuning curves for social vision
Varrier, R. S.; Su, Z.; Liang, Q.; Benson, T. G.; Jolly, E.; Finn, E. S.
10.1101/2025.01.19.633772 — neuroscience — Posted on 2025-01-19
2352 Identification of Human Pathways Acting on Nuclear Non-Coding RNAs Using the Mirror Forward Genetic Approach
Che, R.; Panah, M.; Mirani, B.; Knowles, K.; Ostapovich, A.; Majumdar, D.; Chen, X.; DeSimone, J.; White, W.; Noonan, M.; Luo, H.; Alexandrov, A.
10.1101/2024.09.26.615073 — genetics — Posted on 2025-01-19
2353 Predicting and phase targeting brain oscillations in real-time
Jongejan, S. L.; van der Heijden, C.; Patriota, J.; Talamini, L. M.
10.1101/2024.10.12.617974 — neuroscience — Posted on 2025-01-19
2354 Neuronal cell adhesion molecule (NRCAM) variant defined by microexon skipping is an essential, antigenically distinct, and targetable proteoform in high-grade glioma
Sehgal, P.; Naqvi, A. S.; Higgins, M.; Liu, J.; Harvey, K.; Jarroux, J.; Kim, T.; Mankaliye, B.; Mishra, P.; Watterson, G.; Fine, J.; Davis, J.; Hayer, K. E.; Castro, A.; Mogbo, A.; Drummer, C.; Martinez, D.; Koptyra, M. P.; Ang, Z.; Wang, K.; Farrel, A.; Quesnel-Vallieres, M.; Barash, Y.; Spangler, J. B.; Rokita, J. L.; Resnick, A. C.; Tilgner, H. U.; DeRaedt, T.; Powell, D. J.; Thomas-Tikhonenko, A.
10.1101/2025.01.09.631916 — cancer biology — Posted on 2025-01-19
2359 The mitophagy receptor BNIP3L/Nix coordinates nuclear calcium signaling to modulate the muscle phenotype.
Field, J. T.; Chapman, D.; Hai, Y.; Ghavami, S.; West, A. R.; Ozerklig, B.; Saleem, A.; Kline, J.; Mendelson, A. A.; Kindrachuk, J.; Triggs-Raine, B.; Gordon, J. W.
10.1101/2023.03.18.532760 — cell biology — Posted on 2025-01-19
2360 A common stay-on-goal mechanism in anterior cingulate cortex for information and effort choices
Gonzalez, V. V.; Malvaez, M.; Yeghikian, A.; Wissing, S.; Sharpe, M.; Wassum, K. M.; Izquierdo, A.
10.1101/2024.10.23.619920 — neuroscience — Posted on 2025-01-19
2364 IL-9 as a naturally orthogonal cytokine with optimal JAK/STAT signaling for engineered T cell therapy
Jiang, H.; Limsuwannarot, S.; Kulhanek, K. R.; Pal, A.; Rysavy, L. W.; Su, L.; Labiad, O.; Testa, S.; Ogana, H.; Waghray, D.; Tao, P.; Jude, K. M.; Seet, C. S.; Crooks, G. M.; Moding, E. J.; Garcia, K. C.; Kalbasi, A.
10.1101/2025.01.15.633105 — immunology — Posted on 2025-01-19
2370 Fire shifts the structure and dynamics of woody plant communities in a mediterranean coastal dune ecosystem
Mira, A. F.; Medina, N. G.; Chozas, S.; Divieso, R.; Castro-Rivadeneyra, J.; Diaz-Barradas, M. C.; Hortal, J.
10.1101/2025.01.14.633058 — ecology — Posted on 2025-01-19
2371 Investigation of the HLA locus in autopsy-confirmed progressive supranuclear palsy
Wang, J.; Forrest, S. L.; Dasari, S.; Tanaka, H.; Rogaeva, E.; Tartaglia, C.; Fox, S.; Lang, A. E.; Kalyaanamoorthy, S.; Kovacs, G. G.
10.1101/2025.01.14.632901 — immunology — Posted on 2025-01-19
2372 Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contact Sites Precede Major (Mal)adaptations in Aging Skeletal Muscle and are Prevented by Exercise
Allen, R. J.; Kronemberger, A.; Shi, Q.; Pope, M.; Cuadra-Munoz, E.; Son, W.; Song, L.-S.; Anderson, E. J.; Pereira, R. O.; Lira, V. A.
10.1101/2025.01.14.633043 — physiology — Posted on 2025-01-19
2373 Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation
Wang, Y.; Wu, Y.; Zhang, H.; Liu, X.; Ling, J.; Zhou, X.; Song, A.; Sun, L.; Qiu, H.; Yuan, X.; Xiong, H.; Zou, Y.
10.1101/2024.11.04.610003 — bioinformatics — Posted on 2025-01-19
2376 Opsin-based photoreception in Crinoids: a molecular and behavioural study of Antedon bifida
Nonclercq, Y.; Lienard, M.; Lourtie, A.; Duthoo, E.; Vanespen, L.; Eeckhaut, I.; Flammang, P.; Delroisse, J.
10.1101/2024.08.14.607903 — zoology — Posted on 2025-01-19
2378 A High-Throughput Bone Marrow 3D Co-Culture System to Develop Resistance to B Cell Receptor Signaling Targeted Agents in B Cell Non-Hodgkin Lymphoma
Zadro, A.; Arribas, A. J.; Colombo, M. V.; Cannas, E.; Spriano, F.; Cascione, L.; Mensah, A. A.; Simonetta, F.; Petta, D.; Arrigoni, C.; Candrian, C.; Moretti, M.; Bertoni, F.
10.1101/2025.01.14.632958 — cancer biology — Posted on 2025-01-19
2379 Spatial map of native duct cell populations in human pancreas and their representation in pancreatic cancers
Van den Bossche, J.-L.; Van der Vliet, M.; Michiels, E.; Senar, O. A.; Madran, Z.; Coolens, K.; Van Lint, S.; Nacher, M.; Arsenijevic, T.; Messaoudi, N.; Lefesvre, P.; Montanya, E.; Rovira, M.; Van Laethem, J.-L.; Baldan, J.; Houbracken, I.; Rooman, I.
10.1101/2025.01.14.632911 — cancer biology — Posted on 2025-01-19
2380 Transcriptomic signature reveals sensitivity to tubulin inhibitors in colon cancer
Linares-Blanco, J.; Chicote, I.; Ros, J.; Alcantara, A. M.; Martinez-Quintanilla, J.; Elez, E.; Palmer, H. G.; Fernandez-Lozano, C.; Seoane, J. A.
10.1101/2025.01.14.633026 — cancer biology — Posted on 2025-01-19
2381 Foundational Architecture Enabling Federated Learning for Training Space Biomedical Machine Learning Models between the International Space Station and Earth
Casaletto, J. A.; Foley, P.; Fernandez, M.; Sanders, L. M.; Scott, R. T.; Ranjan, S.; Jain, S.; Haynes, N.; Boerma, M.; Costes, S. V.; Mackintosh, G.
10.1101/2025.01.14.633017 — bioinformatics — Posted on 2025-01-19
2384 Mapping spatially-resolved transcriptomes in systemic sclerosis
Li, Z.; Rigau, A. R.; Xie, W.; Shao, X.; Li, Y.-N.; Matei, A. E.; Zou, H.; Pinello, L.; Distler, J. H. W.; He, R.; Liang, M.
10.1101/2025.01.14.632962 — immunology — Posted on 2025-01-19
2389 Intraductal Papillary Mucinous Neoplasm Cellular Plasticity linked with Repeat Element Dysregulation
Pankaj, A.; Raabe, M. J.; Song, Y.; Patel, B. K.; Xu, K.; Kocher, J. R.; Richieri, P.; Caldwell, N. J.; Ni, P.; Ganci, M. L.; Nieman, L. T.; Zhang, M. L.; Mino-Kenudson, M.; Deshpande, V.; Bardeesy, N.; Fernandez Del-Castillo, C.; Aryee, M. J.; Ting, D. T.; Hernandez-Barco, Y. G.
10.1101/2025.01.14.632658 — cancer biology — Posted on 2025-01-19
2390 The Single-Cell Landscape of Peripheral and Tumor-infiltrating Immune Cells in HPV- HNSCC
Galvani, R. G. A.; Rojas, A.; Matuck, B. F.; Rupp, B. T.; Kumar, N.; Huynh, K.; de Biagi, C. A. O.; Liu, J.; Sheth, S.; Krol, J. M. M.; Maracaja-Coutinho, V.; Byrd, K. M.; Severino, P.
10.1101/2025.01.14.632928 — cancer biology — Posted on 2025-01-19
2392 Digital Phage Biology in Droplets
Givelet, L.; von Schoenberg, S.; Katzmeier, F.; Simmel, F. C.
10.1101/2025.01.14.632946 — biophysics — Posted on 2025-01-19
2393 Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP and its antibody response characterisation
Batra, S.; Olmo, F.; Ragan, T. J.; Frank, A. M.; Kaplan, M.; Lancey, C.; Assadipapari, M.; Ying, C.; Struwe, W. B.; Hesketh, E.; Kelly, J. M.; Barfod, L.; Campeotto, I.
10.1101/2024.03.26.586384 — biophysics — Posted on 2025-01-19
2398 New insights into the cis-regulation of the CFTR gene in pancreatic cells
Blotas, C.; Le Nabec, A.; Collobert, M.; Bulcaen, M.; Carlon, M.; Ferec, C.; Moisan, S.
10.1101/2025.01.14.632890 — genomics — Posted on 2025-01-19
2399 Deciphering Transcription in Cryptosporidium parvum: Polycistronic Gene Expression and Chromatin Accessibility
Xiao, R.; de Paula Baptista, R.; Agyabeng-Dadzie, F.; Li, Y.; Dong, Y.; Schmitz, R. J.; Glenn, T. C.; Kissinger, J. C.
10.1101/2025.01.17.633476 — genetics — Posted on 2025-01-19
2401 KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1
Wang, X.; Bai, Z.; Wallis, C.; Wang, H.; Han, Y.; Jin, R.; Lei, M.; Yang, T.; Gu, C.; Jessen, H.; Shears, S.; Sun, Y.; Corry, B.; Zhang, Y.
10.1101/2025.01.17.633679 — molecular biology — Posted on 2025-01-19
2402 Native nucleosome-positioning elements for the investigation of nucleosome repositioning
Chen, R.-W.; Stoeber, S. D.; Nodelman, I. M.; Chen, H.; Yang, L.; Bowman, G.; Bai, L.; Poirier, M. G.
10.1101/2025.01.17.633597 — molecular biology — Posted on 2025-01-19
2403 Investigating antiviral pathways in Atlantic salmon cells through interferon receptor knockouts via CRISPR-Cas9
Reza, M. A. N.; Harvey, T. N.; Ahmed Abdelrahim Gamil, A.; Evensen, O.; Gillard, G. B.; Sandvik, G. K.
10.1101/2025.01.14.632998 — immunology — Posted on 2025-01-19
2404 Distinct causes of three phenotypic hallmarks of hematopoietic aging
Chia, J. J.; Singh, A.; Lin, Y.; Popko, N.; Mastro, D.; Liu, Y.; Tran, T.; King, J. K.; Rao, D. S.; Hoffmann, A.
10.1101/2025.01.14.632900 — immunology — Posted on 2025-01-19
2407 Triple-effect correction for Cell Painting data with contrastive and domain-adversarial learning
Yan, C.; Zhang, Y.; Feng, J.; Hua, H.; Ruan, Z.; Li, Z.; Li, S.; Yan, C.; Li, P.; Liu, J.; Chen, S.
10.1101/2025.01.13.632874 — bioinformatics — Posted on 2025-01-19
2411 The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B
Yang, X.; Medina, P. C.; Gopalswamy, M.; Vaidya, A.; Schavier, S.; Oltzen, S.; Mossner, S.; Huang, A.; Qi, J.; Floss, D.; Uhrberg, M.; Gohlke, H.; Scheu, S.
10.1101/2025.01.17.633572 — biochemistry — Posted on 2025-01-19
2412 Testing for divergence in a plant symbiont across two natural environmental gradients
Chang, C.-Y.; Topping-Brown, T.; Rud, J. L.; Calvert, M. B.; Bencosme, G.; Robinson, L. J.; Wood, C.
10.1101/2025.01.14.632453 — evolutionary biology — Posted on 2025-01-18
2415 REV7 associates with ATRIP and inhibits ATR kinase activity
Biller, M.; Kabir, S.; Nipper, S.; Allen, S.; Kayali, Y.; Kuncik, S.; Sasanuma, H.; Zhou, P.; Vaziri, C.; Tomida, J.
10.1101/2025.01.17.633588 — molecular biology — Posted on 2025-01-18
2417 Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
Cherdyntseva, V.; Paulson, J.; Adakli, S.; Gagne, J.-P.; Aouami, M.; Ubieto-Capella, P.; Gonzalez-Acosta, D.; Bakker, C.; Poirier, G. G.; Taneja, N.; Lopes, M.
10.1101/2025.01.18.633737 — molecular biology — Posted on 2025-01-18
2420 Temperature vaulting: A method for screening selective, slow- and tight-binding inhibitors targeting kinases in their non-native state
Suzuki, S.; Umezawa, K.; Furuie, G.; Kikuchi, M.; Nakamura, D. G. M.; Fukahori, N.; Kimura, N.; Yamakawa, M.; Niwa, T.; Umehara, T.; Hosoya, T.; Kii, I.
10.1101/2025.01.15.632643 — biophysics — Posted on 2025-01-18
2421 Allometric spreading and focal adhesion collective organization are coordinated by cell-scale geometrical constraints
Bimbard, C.; Wahhod, A.-A.; Mitrossilis, D.; Vermeil, J.; Bousquet, R.; Richert, A.; Pereira, D.; Durand-Smet, P.; Asnacios, S.; Asnacios, A.; Etienne, J.; Fouchard, J.
10.1101/2025.01.17.632363 — biophysics — Posted on 2025-01-18
2422 Atomic Force Microscopy reveals differences in mechanical properties linked to cortical structure in mouse and human oocytes
Bulteau, R.; Barbier, L.; Lamour, G.; Lemseffer, Y.; Verlhac, M.-H.; Tessandier, N.; Labrune, E.; Lenz, M.; Terret, M.-E.; Campillo, C.
10.1101/2025.01.14.632898 — biophysics — Posted on 2025-01-18
2423 Anionic lipid catalyzes the generation of cytotoxic insulin oligomers
Saha, J.; Wolszczak, A.; Kaur, N.; Widanage, M. C. D.; McCalpin, S. D.; Fu, R.; Ali, J.; Ramamoorthy, A.
10.1101/2025.01.14.633028 — biophysics — Posted on 2025-01-18
2424 KILDA: identifying KIV-2 repeats from kmers
Molitor, C.; Labidi, T.; Rimbert, A.; Cariou, B.; Di Filippo, M.; Bardel, C.
10.1101/2025.01.17.631891 — bioinformatics — Posted on 2025-01-18
2426 Lymphoid-tissue-on-chip recapitulates human antibody responses in vitro
Teufel, C.; Schlemmer, A.-S.; Eiken, A. W.; Wagoner, Z. W.; Voehringer, D.; Christ, L.; Dulovic, A.; Marsall, P.; Fandrich, M.; Bras, E. J. S.; Marzi, J.; Baerhold, F.; Philipp, J.; Becker, S.; Wagar, L. E.; Loskill, P.
10.1101/2025.01.14.632762 — bioengineering — Posted on 2025-01-18
2428 Admixture and environmental fluctuations shape the evolutionary history of a predator radiation in East Africa's Lake Tanganyika
Rick, J. A.; Junker, J.; Lewanski, A. L.; Swope, B.; McGlue, M. M.; Sweke, E. A.; Kimirei, I. A.; Seehausen, O.; Wagner, C. E.
10.1101/2025.01.14.633002 — evolutionary biology — Posted on 2025-01-18
2430 Stone Age anthropogenic impacts to forest development in the interior Scandinavian Peninsula
Bertheussen, A.; Wright, D. K.; Dahl, S. O.; Birk, J. J.; Bergman, J.; Buckby, J.; Fiedler, S.; Mjaerum, A.
10.1101/2025.01.15.632029 — ecology — Posted on 2025-01-18
2432 Morpho-functional timeline of progressive cystic fibrosis pancreatic exocrine and endocrine pathology derived from semi-quantitative scoring and AI-driven quantitativeimage analysis
Al-Selwi, Y.; Tiniakos, D.; Richardson, S. J.; Flaxman, C. S.; Russell, L.; Palmer, M.; Coulthard, R.; Maheshwari, R.; Dyson, N.; Honkanen-Scott, M.; Kloeppel, G.; Shaw, J. A.; Kattner, N.
10.1101/2025.01.14.631729 — pathology — Posted on 2025-01-18
2435 Genome assemblies of Indian desi cattle reveals hotspots of rearrangements and immune-related genetic diversity
Azam, S.; Sahu, A.; Kadivella, M.; Khan, A. W.; Neupane, M.; Tassell, C. P. V.; Rosen, B. D.; Gandham, R. K.; Rath, S. N.; Majumdar, S. S.
10.1101/2025.01.14.632934 — genomics — Posted on 2025-01-18
2436 Spacer Extension Reconciles Specificity and Activity in High-Fidelity Cas9 Genome Editing
Lu, Z.; Wei, R.; Zheng, R.; Shin, Y.-C.; Zhang, Q.; Li, J.; Wang, X.; Wei, Y.; Liu, B.; Chen, Y.; Zhang, H.; Chen, H.; Ma, L.
10.1101/2025.01.16.633458 — genomics — Posted on 2025-01-18
2437 Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk
Khouri-Farah, N.; Winchester, E. W.; Schilder, B. M.; Robinson, K.; Curtis, S. W.; Skene, N. M.; Leslie-Clarkson, E.; Cotney, J.
10.1101/2025.01.18.633396 — developmental biology — Posted on 2025-01-18
2438 Intestinal enteroendocrine cell subtype differentiation and hormone production in zebrafish
Morash, M.; Kay, R. G.; Soderblom, E. J.; MacLean, G. H.; Wen, J.; Moore, P. J.; Lickwar, C. R.; Gribble, F. M.; Reimann, F.; Liddle, R. A.; Rawls, J. F.
10.1101/2025.01.17.633579 — developmental biology — Posted on 2025-01-18
2440 Microglial SIRT2 deficiency aggravates cognitive decline and amyloid pathology in Alzheimer's disease
Sola-Sevilla, N.; Garmendia-Berges, M.; Aleixo, M.; Mera-Delgado, M. C.; Solas, M.; Tordera, R. M.; Garcia-Carracedo, L.; Exposito, S.; Anaya-Cubero, E.; Fernandez-Irigoyen, J.; Guruceaga, E.; Santamaria, E.; Martin, E. D.; Puerta, E.
10.1101/2025.01.17.633523 — neuroscience — Posted on 2025-01-18
2441 Impact of meningioma and glioma on whole-brain dynamics
Junca, A.; Escrichs, A.; Martin, I.; Deco, G.; Patow, G. A.
10.1101/2025.01.17.633524 — neuroscience — Posted on 2025-01-18
2444 Patagonian fjords/channels vs. open ocean: phytoplankton molecular diversity in Southern Chilean coast
Fuenzalida, G.; Sanchez, R.; Silva, A.; Figueroa, A.; Artal, O.; Jorquera, M.; Trefault, N.; Espinoza, O.; Guzman, L.
10.1101/2025.01.15.632644 — ecology — Posted on 2025-01-18
2445 Targeting histone acetylation enables epigenetic modulation of inflammatory pathways, a novel therapeutic strategy for rheumatoid arthritis
Brinkmann, M.; Tosevska, A.; Luckerbauer, B.; Madern, M.; Goeschl, L.; Ellmeier, W.; Aletaha, D.; Preglej, T.; Bonelli, M.
10.1101/2025.01.14.632975 — immunology — Posted on 2025-01-18
2447 Decoding MASLD Progression: A Molecular Trajectory-Based Framework for Modelling Disease Dynamics
Kamzolas, I.; Koutsandreas, T.; Barker, C. G.; Vathrakokoili Pournara, A.; Weston, H. N.; Vacca, M.; Papatheodorou, I.; Vidal-Puig, A.; Petsalaki, E.
10.1101/2025.01.14.632908 — systems biology — Posted on 2025-01-18
2449 Computational Modeling of Ternary Complex Formation and Targeted Protein Degradation Mediated by Molecular Glues
Izaguirre, J. A.; Wu, Y.; McDargh, Z.; Palpant, T.; Razavi, A. M.; Trovato, F.; Koh, C.; Xu, H.
10.1101/2025.01.13.632817 — bioinformatics — Posted on 2025-01-18
2451 Interpretable adenylation domain specificity prediction using protein language models
Adduri, A.; McNutt, A.; Ellington, C.; Suraparaju, K.; Fang, N.; Yan, D.; Krummenacher, B.; Li, S.; Bodden, C.; Xing, E.; Behsaz, B.; Koes, D. R.; Mohimani, H.
10.1101/2025.01.13.632878 — bioinformatics — Posted on 2025-01-18
2452 Cell Type-Specific and Diabetic Kidney Disease-Associated Expression of Long Non-Coding RNAs in Human Kidneys
de Klerk, J. A.; Slieker, R.; Parker, W.; Wu, H.; Muto, Y.; Postma, R. J.; 't Hart, L. M.; Peerlings, J. H. D.; Herrewijnen, F. J.; Song, H. I.; Spijker, S. H.; Dumas, S. J.; Koning, M.; van der Pluijm, L. A. K.; Baelde, H. J. J.; Gerrits, T.; Rotmans, J. I.; van Zonneveld, A. J.; van Solingen, C.; Humphreys, B.; Bijkerk, R.
10.1101/2025.01.14.632910 — bioinformatics — Posted on 2025-01-18
2453 Limit of detection of Raman spectroscopy using polystyrene particles from 25 to 1000 nm in aqueous suspensions
Mayorga, C.; Athalye, S.; Boodaghidizaji, M.; Sarathy, N.; Hosseini, M.; Ardekani, A.; Verma, M. S.
10.1101/2025.01.17.632088 — bioengineering — Posted on 2025-01-18
2454 An improved FLARE system for recording and manipulating neuronal activity
Zhou, G.; Li, R.; Bartolik, O.; Ma, Y.; Wan, W. W.; Meng, J.; Hu, Y.; Ye, B.; Wang, W.
10.1101/2025.01.13.632875 — bioengineering — Posted on 2025-01-18
2456 Evolutionary trajectories of immune escape across cancers
Chen, W.; Baker, T.; Zhang, Z.; Ogilvie, H. A.; Van Loo, P.; Gu, S.
10.1101/2025.01.17.632799 — evolutionary biology — Posted on 2025-01-18
2457 Gene family evolution reveals dietary adaptations in butterflies and moths
Weng, Y.-M.; Martinez, J. I.; Markee, A.; Plotkin, D.; Sondhi, Y.; Mongue, A. J.; Frandsen, P. B.; Kawahara, A. Y.
10.1101/2025.01.15.632883 — evolutionary biology — Posted on 2025-01-18
2458 Rising temperatures favour parasite virulence and parallel molecular evolution following a host jump
Hector, T. E.; Kreiner, J. M.; Forward, J. C.; Hoang, K. L.; Stevens, E. J.; Johnson, S.; Li, J.; King, K. C.
10.1101/2025.01.14.632940 — evolutionary biology — Posted on 2025-01-18
2461 Non-invasive eDNA reveals the ecological and genetic status of the Western Capercaillie (Tetrao urogallus aquitanicus) in the Eastern Pyrenees
Buso, P.; Paris, C.; Tassaint, M.; Canal, M.; Danielo, S.; Gibert, A.; Palme, R.; Macho-Maschler, S.; Llauro, C.; Jacob, G.; Delorme-Hinoux, V.; Bertrand, J.; Rey, O.
10.1101/2025.01.14.632749 — ecology — Posted on 2025-01-18
2462 PD-1 prelimits both the cytotoxic and exhaustion potential in thymic CD8+ T cells and impacts the maintenance of peripheral tumor immunity
Mao, Z.; Hirdler, J. B.; Gicobi, J. K.; Maynes, M.; Hsu, M. A.; Dellacecca, E. R.; Zhang, W.; Teske, J. J.; Li, Y.; Zhao, G.; Lucien-matteoni, F.; Borges da Silva, H.; Billadeau, D. D.; Dong, H.
10.1101/2025.01.18.631253 — immunology — Posted on 2025-01-18
2464 Cholinergic Modulation of Chandelier Cells via Heteromeric Nicotinic Receptors in Prefrontal Cortex
Martinez-Marquez, E.; Reyes-Leon, S.; Garcia-San-Jose, F.; Lopez-Begines, S.; Nieto-Gonzalez, J. L.; Garcia-Junco-Clemente, P.
10.1101/2025.01.18.633708 — neuroscience — Posted on 2025-01-18
2466 Evaluating plant growth-defence trade-offs by modelling the interaction between primary and secondary metabolism
Zrimec, J.; Correa, S.; Zagorscak, M.; Petek, M.; Bleker, C.; Stare, K.; Schuy, C.; Sonnewald, S.; Gruden, K.; Nikoloski, Z.
10.1101/2024.09.15.613124 — systems biology — Posted on 2025-01-18
2468 Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes
Liu, Y.; Rao, S.; Hoskins, I.; Geng, M.; Zhao, Q.; Chacko, J.; Ghatpande, V.; Qi, K.; Persyn, L.; Wang, J.; Zheng, D.; Zhong, Y.; Park, D.; Cenik, E. S.; Agarwal, V.; Ozadam, H.; Cenik, C.
10.1101/2024.08.11.607360 — bioinformatics — Posted on 2025-01-18
2469 Predicting the translation efficiency of messenger RNA in mammalian cells
Zheng, D.; Persyn, L.; Wang, J.; Liu, Y.; Montoya, F. U.; Cenik, C.; Agarwal, V.
10.1101/2024.08.11.607362 — bioinformatics — Posted on 2025-01-18
2471 Deep Learning Unravels Potential Antibiotic-Resistance Drugs against Klebsiella Pneumoniae
Lin, P.; Zhou, J.; Meng, S.; Lei, Z.; Jin, L.; Qiu, H.; Xu, Y.; Hsu, T.; Bu, Y.; Qin, G.; Zhang, W.
10.1101/2024.11.25.625191 — bioinformatics — Posted on 2025-01-18
2472 Structure of dimerized assimilatory NADPH-dependent sulfite reductase reveals the minimal interface for diflavin reductase binding
Ghazi Esfahani, B.; walia, n.; Neselu, K.; Garg, Y.; Aragon, M.; Askenasy, I.; Wei, A.; mendez, j.; Stroupe, M. E.
10.1101/2024.06.14.599029 — molecular biology — Posted on 2025-01-18
2473 Prophages are Infrequently Associated With Antibiotic Resistance in Pseudomonas aeruginosa Clinical Isolates
Chang, T. H.; Pourtois, J.; Haddock, N.; Furkuawa, D.; Kelly, K. E.; Amanatullah, D.; Burgener, E. B.; Milla, C.; Banaei, N.; Bollyky, P.
10.1101/2024.06.02.595912 — microbiology — Posted on 2025-01-18
2474 Hypoxia-inducible factor 1 protects neurons from Sarm1-mediated neurodegeneration
Meraner, P.; Avetisyan, A.; Swift, K.; Cheng, Y.-C.; Barria, R.; Freeman, M.
10.1101/2025.01.17.633664 — neuroscience — Posted on 2025-01-18
2475 Fentanyl blockade of K+ channels contribute to Wooden Chest Syndrome
Wei, A. D.; Burgraff, N. J.; Oliveira, L. M.; Moreira, T. S.; Ramirez, J.-M.
10.1101/2025.01.17.633656 — neuroscience — Posted on 2025-01-18
2476 Conditioning electrical stimulation enhances functional rewiring in a mouse model of nerve transfer to treat chronic spinal cord injury
Jara, J. S.; Soliman, M.; Bernstein, A.; di Grazia, P.; Ferguson, A. R.; Brown, J. M.; Torres-Espin, A.; Hollis, E.
10.1101/2025.01.17.633666 — neuroscience — Posted on 2025-01-18
2478 Partial Wwox Loss of Function Increases Severity of Murine Sepsis and Neuroinflammation
De La Cruz, P.; Gomes, M.; Lockett, A.; Fisher, A.; Cook, T.; Smith, P.; Lloyd, C.; Twigg, H.; Oblak, A.; Aldaz, C. M.; Machado, R.
10.1101/2025.01.17.633677 — neuroscience — Posted on 2025-01-18
2479 Simultaneous EEG-PET-MRI identifies temporally coupled, spatially structured hemodynamic and metabolic dynamics across wakefulness and NREM sleep
Chen, J. E.; Lewis, L.; Coursey, S.; Catana, C.; Polimeni, J.; Fan, J.; Dropppa, K.; Patel, R.; Wey, H.-Y.; Chang, C.; Manoach, D.; Price, J.; Sander, C.; Rosen, B. R.
10.1101/2025.01.17.633689 — neuroscience — Posted on 2025-01-18
2483 Variational Autoencoder-based Model Improves Polygenic Prediction in Blood Cell Traits
Li, X.; Pang, M.; Wen, J.; Zhou, L. Y.; Raffield, L. M.; Zhou, H.; Yao, H.; Chen, C.; Sun, Q.; Li, Y.
10.1101/2025.01.13.632820 — bioinformatics — Posted on 2025-01-18
2484 New deep-branching environmental plastid genomes on the algal tree of life
Jamy, M.; Huber, T.; Antoine, T.; Ruscheweyh, H.-J.; Paoli, L.; Pelletier, E.; Delmont, T. O.; Burki, F.
10.1101/2025.01.16.633336 — evolutionary biology — Posted on 2025-01-18
2489 GlycoAvatars: Bead-Coated Membrane Models for Studying the Cancer-Immune Cells Interactome
Miranda, A.; Relvas-Santos, M.; Lourenco, C.; Ferreira, E.; Cunha, D. M.; Palmeira, C.; Santos, L. L.; Mattila, P.; Ferreira, J. A.
10.1101/2025.01.15.633146 — biochemistry — Posted on 2025-01-18
2492 The Power of Three: Dynactin associates with three dyneins under load for greater force production
Rao, L.; Liu, X.; Berger, F.; McKenney, R. J.; Arnold, M.; Stengel, K.; Sidoli, S.; Gennerich, A.
10.1101/2025.01.14.632506 — biophysics — Posted on 2025-01-18
2493 LARP6 regulates the mRNA translation of fibrogenic genes in liver fibrosis
Kim, H. Y.; Mizrahi, O.; Lee, W.; Rosenthal, S. B.; Han, C.; Yee, B. A.; Blue, S. M.; Diaz, J.; Jonnalagadda, J.; Hokutan, K.; Jang, H.; Ma, C.-T.; Bobkov, A.; Sergienko, E.; Jackson, M. R.; Stefanovic, B.; Kisseleva, T.; Yeo, G. W.; Brenner, D. A.
10.1101/2025.01.16.633226 — cell biology — Posted on 2025-01-18
2494 Genetically encoded mechano-sensors with versatile readouts and compact size
Ren, Y.; Yang, J.; Saito, T.; Glomb, O.; Mousavi, S. I.; Naughton, B.; de Fontnouvelle, C.; Fujita, B.; Schlieker, C.; Yogev, S.; Zhang, Y.; Berro, J.
10.1101/2025.01.16.633409 — cell biology — Posted on 2025-01-18
2495 Identification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells
Kour, D.; Bowen, C. A.; Srivastava, U.; Nguyen, H. M.; Kumari, R.; Kumar, P.; Brandelli, A. D.; Bitarafan, S.; Tobin, B. R.; Wood, L. B.; Seyfried, N.; Wulff, H.; Rangaraju, S.
10.1101/2025.01.16.633279 — cell biology — Posted on 2025-01-18
2499 The AMPKa2/PHF2 axis is critical for turning over lipid droplets during muscle stem cell fate
Cicciarello, D.; Mouradian, S.; Pitchecanin, M.; Jarassier, W.; Kneppers, A.; Mounier, R.; Schaeffer, L.; Scionti, I.
10.1101/2025.01.18.630727 — cell biology — Posted on 2025-01-18
2501 Candida albicans enhances melanoma cell aggressiveness through p38-MAPK and HIF-1α pathways and metabolic reprogramming
Aparicio-Fernandez, L.; Cazalis-Bereicua, N.; Areitio, M.; Rodriguez-Erenaga, O.; Abio-Dorronsoro, L.; Martin-Souto, L.; Buldain, I.; Marquez, J.; Benedicto, A.; Arteta, B.; Macias-Camara, N.; Gonzalez, M.; Martin Rodriguez, J. E.; Aransay, A. M.; Pellon, A.; Moyes, D. L.; Anguita, J.; Rementeria, A.; Antoran, A.; Ramirez-Garcia, A.
10.1101/2025.01.17.633543 — microbiology — Posted on 2025-01-18
2504 Schistosoma mansoni antigen induced innate immune memory features mitochondrial biogenesis and can be inhibited by ovarian produced hormones
Oviedo, J. M.; Cortes-Selva, D.; Marchetti, M.; Gordon, L.; Gibbs, L.; Maschek, J. A.; Cox, J.; Frietze, S.; Amiel, E.; Fairfax, K. C.
10.1101/2025.01.14.632838 — immunology — Posted on 2025-01-18
2507 GlycoAvatars: Bead-Coated Membrane Models for Studying the Cancer-Immune Cells Interactome
Miranda, A.; Relvas-Santos, M.; Lourenco, C.; Ferreira, E.; Cunha, D. M.; Palmeira, C.; Santos, L. L.; Ferreira, J. A.; Mattila, P.
10.1101/2025.01.15.633146 — biochemistry — Posted on 2025-01-18
2510 Distinct Classes of Gut Bacterial Molybdenum-Dependent Enzymes Produce Urolithins
Bae, M.; Dong, X.; Avila-Pacheco, J.; Inyama, F.; Hill-Maini, V.; Clish, C.; Balskus, E. P.
10.1101/2025.01.17.632430 — biochemistry — Posted on 2025-01-18
2512 Sequencing-based Spatial Transcriptomics with scRNA-seq Sensitivity
Liao, R.; Fu, D.; Xu, Z.; Liang, H.; Zhou, X.; Chen, Y.; Liu, X.; Cheng, J.; Guo, R.; Li, C.; Xia, H.; Li, G.; Feng, D.; Chen, W.; Chen, Y.; Chen, L.; Huang, Z.; Zhou, Y.; Chen, Q.; Chen, D.; Xuan, S.; Zhang, C.; Lu, Y.; Wang, H.; Feng, T.; Bao, Y.; Zhao, L.; Liu, E.; Wang, G.
10.1101/2025.01.15.633111 — molecular biology — Posted on 2025-01-18
2513 Comprehensive analysis of 37 composts: microbial indicators for soilborne disease suppression in three plant-pathogen systems
Logo, A.; Boppre, B.; Fuchs, J.; Maurhofer, M.; Oberhaensli, T.; Thuerig, B.; Widmer, F.; Flury, P.; Mayerhofer, J.
10.1101/2025.01.17.633646 — molecular biology — Posted on 2025-01-18
2516 Sialic acid-containing glycolipids extend the receptor repertoire of Enterovirus-D68
Pereirinha da Silva, A. K.; van Trijp, J. P.; Montenarie, A.; Fok, J.; Sooksawasdi Na Ayudhya, S.; Pieters, R. J.; Boons, G.-J.; van Riel, D.; de Vries, R.; Bauer, L.
10.1101/2025.01.17.633529 — microbiology — Posted on 2025-01-18
2518 Quantitative proteomics of infected macrophages reveals novel Leishmania virulence factors
Hagedorn, N.; Fradera-Sola, A.; Mitnacht, M.; Gold, T.; Schleicher, U.; Butter, F.; Janzen, C. J.
10.1101/2025.01.17.633565 — microbiology — Posted on 2025-01-18
2519 Systematic Determination of the Impact of Structural Edits on Accumulation into Mycobacteria
Dash, R.; Liu, Z.; Lepori, I.; Chordia, M.; Holsinger, K.; Zhang, H.; Kenyon, R.; Im, W.; Siegrist, M. S.; Pires, M.
10.1101/2025.01.17.633618 — microbiology — Posted on 2025-01-18
2520 Protocol for the production of an Arenavirus and Hantavirus host-pathogen database: Project ArHa.
Simons, D.; Rivero, R.; Martinez-Checa Guiote, A.; Gordon, H.; Milne, G. C.; Rickard, G.; Redding, D. W.; Seifert, S. N.
10.1101/2025.01.17.633514 — microbiology — Posted on 2025-01-18
2521 Gonococcal aggregation causes upregulation of genes involved in antibiotic tolerance
Kraus-Roemer, S.; Wielert, I.; Rathmann, I.; Volkmann, T. E.; Higgins, P. G.; Maier, B.
10.1101/2025.01.17.633513 — microbiology — Posted on 2025-01-18
2522 Bacterial fitness for plant colonization is influenced by plant growth substrate
Torres, M.; Price, M. N.; Kashanova, A.; Kosina, S. M.; Zhalnina, K.; Northen, T. R.; Deutschbauer, A. M.
10.1101/2025.01.16.633496 — microbiology — Posted on 2025-01-18
2523 Integrated analysis of protein sequence and structureredefines viral diversity and the taxonomy of the Flaviviridae
Simmonds, P.; Butkovic, A.; Grove, J.; Mayne, R.; Mifsud, J. C.; Beer, M.; Bukh, J.; Drexler, J. F.; Kapoor, A.; Lohmann, V.; Smith, D. B.; Stapleton, J. T.; Vasilakis, N.; Kuhn, J. H.
10.1101/2025.01.17.632993 — microbiology — Posted on 2025-01-18
2525 Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein
Britton, G. J.; Mogno, I.; Chen-Liaw, A.; Plitt, T.; Helmus, D.; Bongers, G.; Brough, I.; Colmenero, P.; Lam, L. H.; Bullers, S. J.; Penkava, F.; Reyes-Mercedes, P.; Braun, J.; Jacobs, J.; Desch, A. N.; Gevers, D.; Simmons, S.; Filer, A.; Taylor, P. C.; Bowness, P.; Huttenhower, C.; Littman, D. R.; Dubinsky, M. C.; Raza, K.; Tankou, S. K.; Faith, J. J.
10.1101/2025.01.14.633015 — immunology — Posted on 2025-01-18
2526 The emerging fungal pathogen Candida auris induces IFNγ to colonize mammalian hair follicles
Merrill, E. D.; Prudent, V.; Moghadam, P.; Rodriguez, A.; Hurabielle, C.; Wells, E.; Basso, P.; Scharschmidt, T. C.; Rosenblum, M.; Molofsky, A. B.; Noble, S. B.
10.1101/2025.01.15.632653 — immunology — Posted on 2025-01-18
2527 IL-21-STAT3 axis negatively regulates LAIR1 expression in B cells
Yoshida, K.; Kurata-Sato, I.; Atisha-Fregoso, Y.; Aranow, C.; Diamond, B.
10.1101/2025.01.14.632971 — immunology — Posted on 2025-01-18
2528 Harnessing Extracellular Vesicles for Stabilized and Functional IL-10 Delivery in Macrophage Immunomodulation
Saleh, N. A.; Gagea, M. A.; Vitija, X.; Janovic, T.; Schmidt, J. C.; Deng, C. X.; Kanada, M.
10.1101/2025.01.14.633016 — immunology — Posted on 2025-01-18
2529 Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus-MPro inhibitors with potent in vivo efficacy
Detomasi, T. C.; Degotte, G.; Huang, S.; Suryawanshi, R.; Diallo, A.; Lizzadro, L.; Zapatero-Belinchon, F.; Taha, T. Y.; Li, J.; Richards, A.; Hantz, E.; Alam, Z.; Montano, M.; Malvido, M.; Gumpena, R.; Partridge, J. R.; Correy, G. J.; Carvat, A.; Glenn, I. S.; Rosencrans, J.; Revalde, J.; Anderson, D.; Hultquist, J. F.; Arkin, M. R.; Neitz, J.; Swaney, D. L.; Krogan, N. J.; Shoichet, B.; Verba, K.; Ott, M.; Renslo, A.; Craik, C. S.
10.1101/2025.01.16.633443 — biochemistry — Posted on 2025-01-18
2530 PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer
Liu, F.; Liu, W.; Tan, Y.; Shang, Y.; Ling, S.; Jiang, X.; Zhang, Z.; Sun, S.; Xie, P.
10.1101/2024.08.06.606911 — cancer biology — Posted on 2025-01-18
2531 Transocular detection of premotor Parkinson's disease via retinal capillary neurovascular coupling through functional OCT angiography
Liu, K.; Wang, R.; Huang, L.; Zhang, H.; Gao, M.; Sun, B.; Tan, Y.; Ye, J.; Ding, Z.; Gu, Y.; Zhang, S.; Li, P.
10.1101/2024.08.04.606502 — bioengineering — Posted on 2025-01-18
2537 Effects of systemic oxytocin and beta-3 receptor agonist (CL 316243) treatment on body weight and adiposity in male diet-induced obese rats
Slattery, J. D.; Rambousek, J. R.; Tsui, E.; Honeycutt, M. K.; Goldberg, M.; Graham, J. L.; Wietecha, T. A.; Wolden-Hanson, T.; Williams, A. L.; O'Brien, K. D.; Havel, P. J.; Blevins, J. E.
10.1101/2024.09.27.615550 — neuroscience — Posted on 2025-01-17
2538 Electrophysiological resting-state signatures link polygenic scores to general intelligence
Engler, R.; Stammen, C.; Arnau, S.; Schneider Penate, J.; Metzen, D.; Digutsch, J.; Gajewski, P. D.; Getzmann, S.; Fraenz, C.; Reinders, J.; Streit, F.; Ocklenburg, S.; Schneider, D.; Burke, M.; Hengstler, J.; Watzl, C.; Nitsche, M. A.; Kumsta, R.; Wascher, E.; Genc, E.
10.1101/2025.01.17.633388 — neuroscience — Posted on 2025-01-17
2540 Astrocyte Ca2+ activity regulates node of Ranvier length in the white matter
Lezmy, J.; Quintela-Lopez, T.; Woermann, N.; Mao, S.; Thompson, C.; Attwell, D.
10.1101/2025.01.17.633566 — neuroscience — Posted on 2025-01-17
2541 Associations between epilepsy-related polygenic risk and brain morphology in childhood
Ngo, A.; Liu, L.; Lariviere, S.; Kebets, V.; Fett, S.; Weber, C. F.; Royer, J.; Yu, E.; Rodriguez-Cruces, R.; Zhang, Z.; Ooi, L. Q. R.; Yeo, B. T. T.; Frauscher, B.; Paquola, C.; Caligiuri, M. E.; Gambardella, A.; Concha, L.; Keller, S. S.; Cendes, F.; Yasuda, C. L.; Bonilha, L.; Gleichgerrcht, E.; Focke, N. K.; Kotikalapudi, R.; O'Brien, T. J.; Sinclair, B.; Vivash, L.; Desmond, P. M.; Lui, E.; Vaudano, A. E.; Meletti, S.; Kälviäinwn, R.; Soltanian-Zadeh, H.; Winston, G. P.; Tiwari, V. K.; Kreilkamp, B. A. K.; Lenge, M.; Guerrini, R.; Hamandi, K.; Rüber, T.; Bauer, T.; Devinsky, O.; Strian
10.1101/2025.01.17.633277 — neuroscience — Posted on 2025-01-17
2543 High-throughput protein binder discovery by rapid in vivo selection
Styles, M. J.; Pixley, J. A.; Wei, T.; Basile, C.; Lu, S.; Dickinson, B. C.
10.1101/2025.01.06.631531 — synthetic biology — Posted on 2025-01-17
2546 Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.
Hassan, O.; Pizzagalli, M.; Leary, O.; Zepecki, J. P.; Corseri, A.; Wu, L. J.; Sasipalli, S.; Lee, D.; Hayward, L.; Tran, L.; Fajardo, E.; Fiser, A.; Karambizi, D.; Tapinos, N.
10.1101/2024.03.12.584656 — cancer biology — Posted on 2025-01-17
2547 Texture profile analysis and rheology of plant-based and animal meat
Dunne, R. A.; Darwin, E. C.; Perez Medina, V. E.; Levenston, M.; St. Pierre, S. R.; Kuhl, E.
10.1101/2024.10.11.617917 — bioengineering — Posted on 2025-01-17
2549 From macro to micro: De novo genomes of Aedes mosquitoes enable comparative genomics among close and distant relatives
Morinaga, G.; Balcazar, D.; Badolo, A.; Iyaloo, D.; Tantely, L.; Mouillaud, T.; Sharakhova, M.; Geib, S. M.; Paupy, C.; Ayala, D.; Powell, J. R.; Gloria-Soria, A.; Soghigian, J.
10.1101/2025.01.13.632753 — genomics — Posted on 2025-01-17
2550 Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast
Benning, F. M. C.; Bell, T. A.; Nguyen, T. H.; Syau, D.; Connell, L. B.; Coughlin, M.; Nordstrom, A. E. H.; Ericsson, M.; daCosta, C. J. B.; Chao, L. H.
10.1101/2024.04.26.591372 — evolutionary biology — Posted on 2025-01-17
2552 Rapid adaptive evolution of microbial thermal performance curves
Liu, M. H.; Han, Z.-Y.; Yuan, Y.; DeWitt, K.; Wieczynski, D. J.; Yammine, K. M.; Yammine, A.; Zufall, R.; Siepielski, A.; Chalker, D.; Onishi, M.; Machado, F. A.; Gibert, J. P.
10.1101/2024.04.30.590804 — ecology — Posted on 2025-01-17
2553 Beneath the scuttle: Patterns of bacterial abundance, diversity and distribution in an insect dark taxon
Nowak, K. H.; Hartop, E.; Prus-Frankowska, M.; Buczek, M.; Kolasa, M.; Roslin, T.; Ovaskainen, O. T.; Łukasik, P.
10.1101/2024.08.26.609658 — ecology — Posted on 2025-01-17
2555 Gamma-burst cortical activity in awake behaving macaques
Acland, B. T.; Palanca, B. J. A.; Bijsterbosch, J. D.; Snyder, L. H.
10.1101/2023.09.26.559594 — neuroscience — Posted on 2025-01-17
2558 Optical recordings of unitary synaptic connections reveal high and random local connectivity between CA3 pyramidal cells
Layous, R.; Tamas, B.; Mike, A.; Sipos, E.; Arszovszki, A.; Brunner, J.; Szatai, A.; Yaseen, F.; Andrasi, T.; Szabadics, J.
10.1101/2025.01.15.633173 — neuroscience — Posted on 2025-01-17
2559 Oral prodrug of a novel glutathione surrogate reverses metabolic dysregulation and attenuates neurodegenerative process in APP/PS1 mice
Rao, S. P.; Imam-Fulani, A. O.; Xie, W.; Phillip, S.; Chennavajula, K.; Lind, E. B.; Zhang, Y.; Vince, R.; Lee, M. K.; More, S. S.
10.1101/2025.01.15.633247 — neuroscience — Posted on 2025-01-17
2562 Prior use-dependent plasticity triggers different individual corticomotor responses during persistent musculoskeletal pain
Zamorano, A. M.; Kleber, B.; De Martino, E.; Insausti-Delgado, A.; Vuust, P.; Flor, H.; Graven-Nielsen, T.
10.1101/2025.01.15.633250 — neuroscience — Posted on 2025-01-17
2563 Childhood Maltreatment and Brain Aging During Adulthood
Fleming, L.; Ohashi, K.; Enlow, M. B.; Khoury, J.; Klengel, T.; Lyons-Ruth, K.; Teicher, M.; Ressler, K. J.
10.1101/2025.01.16.633271 — neuroscience — Posted on 2025-01-17
2564 Axon Trafficking Counteracts Aberrant Protein Aggregation in Neurons
Feng, Y.; Luan, T.; Zhang, Z.; Wang, W.; Chu, Y.; Wan, S.; Pan, X.; Li, J.; Liu, Y.; Wang, T.
10.1101/2025.01.16.633295 — neuroscience — Posted on 2025-01-17
2565 Fusobacteria nucleatum determines the expression of amphetamine-induced behavioral responses through an epigenetic phenomenon.
Mabry, S. J.; Cao, X.; Zhu, Y.; Rowe, C. S.; Patel, S.; Gonzalez-Arancibia, C.; Romanazzi, T.; Saleeby, D.; Elam, A.; Lee, H.-T.; Turkmen, S.; Lauzon, S. N.; Hernandez, C. E.; Sun, H.; Wu, H.; Carter, A. M.; Galli, A.
10.1101/2025.01.15.633210 — neuroscience — Posted on 2025-01-17
2566 LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
Adami, A.; Garza, R.; Gerdes, P.; Johansson, P. A.; Dorazehi, F.; Koutounidou, S.; Castilla-Vallmanya, L.; Atacho, D. A. M.; Sharma, Y.; Johansson, J. G.; Tam, O.; Kirkeby, A.; Barker, R. A.; Gale Hammell, M.; Douse, C. H.; Jakobsson, J.
10.1101/2025.01.17.633315 — developmental biology — Posted on 2025-01-17
2567 Reactivation of an Embryonic Cardiac Neural Crest Transcriptional Subcircuit During Zebrafish Heart Regeneration
Dhillon-Richardson, R. M.; Haugan, A. K.; Lyons, L. W.; McKenna, J. K.; Bronner, M. E.; Martik, M. L.
10.1101/2025.01.16.633462 — developmental biology — Posted on 2025-01-17
2569 The ratio of Wnt signaling activity to Sox2 transcription factor levels predicts neuromesodermal fate potential
Morabito, R. M.; Tatarakis, D.; Swick, R.; Stettnisch, S.; Schilling, T. F.; Horsfield, J. A.; Martin, B. L.
10.1101/2025.01.16.633481 — developmental biology — Posted on 2025-01-17
2571 OpenEMMU: a versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics
Contreras, O.; Thekkedam, C.; Zaunders, J.; Aguirre-MacLennan, I.; Murray, N. J.; Gonzalez Cordero, A.; Harvey, R. P.
10.1101/2025.01.17.633495 — developmental biology — Posted on 2025-01-17
2573 Repopulation of the brain with microglia-like cells following intraperitoneal bone marrow cell transfer in microglia-deficient mice.
Taylor, I.; Patkar, O. L.; Liu, Y.; Jacquelin, S.; Ranpura, G.; Carter-Cusack, D.; Ewing, A. D.; Kurniawan, N. D.; Li, M.; Vasoya, D.; He, X.; Dando, O. R.; Kind, P.; Hardingham, G. E.; Bradford, B. M.; Mabbott, N. A.; LeFevre, L.; Pridans, C.; Summers, K. M.; Irvine, K. M.; Hume, D. A.
10.1101/2025.01.16.633478 — neuroscience — Posted on 2025-01-17
2578 Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses
Oriol, L.; Chao, M.; Kollman, G. J.; Dowlat, D. S.; Singhal, S. M.; Steinkellner, T.; Hnasko, T. S.
10.1101/2024.06.07.597996 — neuroscience — Posted on 2025-01-17
2579 Deviation from typical brain activity during naturalistic stimulation is related to personality traits
Jajcay, L.; Tomecek, D.; Androvicova, R.; Fajnerova, I.; Dechterenko, F.; Rydlo, J.; Tintera, J.; Lukavsky, J.; Horacek, J.; Hlinka, J.
10.1101/2024.04.23.586759 — neuroscience — Posted on 2025-01-17
2580 Stress Granules Underlie Acute Myeloid Leukemia Stem Cell Survival and Stress Adaptation
Tajik, A.; Tsao, E.; Jahangiri, S.; Seale, B.; Yee, B. A.; Naritomi, J. T.; Balde, Z.; Cathelin, S.; Chahi, A. K.; Li, L.; Chen, H. T.; Wong, N.; Liu, L.; Joshi, P.; Moreira, S.; McCloskey, C. W.; Khan, S.; Rothamel, K. L.; Boutzen, H.; Bansal, S.; Zeng, A. G. X.; Aigner, S.; Lu, Y.; Dick, J. E.; Kislinger, T.; Khokha, R.; Minden, M. D.; Gingras, A.-C.; Yeo, G. W.; Hope, K. J.
10.1101/2025.01.14.632811 — cancer biology — Posted on 2025-01-17
2581 High-throughput measurement of adipocyte size with open-source software using whole-slide adipose tissue images
Ramalho, A. C.; Gauthier, M.-F.; Maltais-Payette, I.; Ostinelli, G.; Hould, F.; Biertho, L.; Tchernof, A.
10.1101/2024.10.31.621327 — cell biology — Posted on 2025-01-17
2582 Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease
VanPortfliet, J. J.; Lei, Y.; Ramanathan, M.; Martinez, C. G.; Wong, J.; Stodola, T. J.; Hoffmann, B. R.; Pflug, K.; Sitcheran, R.; Kneeland, S. C.; Murray, S. A.; McGuire, P. J.; Cannon, C. L.; West, A. P.
10.1101/2024.05.11.593693 — immunology — Posted on 2025-01-17
2584 Low-Frequency Tibial Neuromodulation Increases Voiding Activity - a Human Pilot Study and Computational Model
McConnell-Trevillion, A.; Jabbari, M.; Ju, W.; Lister, E.; Erfanian, A.; Mitra, S.; Nazarpour, K.
10.1101/2024.05.17.594683 — neuroscience — Posted on 2025-01-17
2585 Serotonin modulates infraslow oscillation in the dentate gyrus during Non-REM sleep
Turi, G. F.; Teng, S.; Chen, X.; Lim, E. C.; Dias, C.; Hu, R.; Wang, R.; Zhen, F.; Peng, Y.
10.1101/2023.05.12.540575 — neuroscience — Posted on 2025-01-17
2586 Spatial Profiling Reveals Equivalence-Derived Molecular Signatures of Brain Mimicry and Adaptation in Breast Cancer Brain Metastases
Umeh Garcia, M.; Yeh, C. Y.; Godfrey, B.; Nunez Perez, P.; Barisano, G.; Varma, S.; Ahmadian, S.; Toland, A.; Granucci, M.; Trinh, T.; Vogel, H.; West, R.; Angelo, M.; Tian, L.; Plevritis, S. K.; Hayden Gephart, M.
10.1101/2025.01.13.631781 — cancer biology — Posted on 2025-01-17
2587 Resistance to BRAF inhibitors drives melanoma sensitivity to Chk1 inhibition
Carvalho, D. G.; Kenski, J. C. N.; Moreira, D. A.; Rajao, M. A.; Krijgsman, O.; Furtado, C.; Boroni, M.; Viola, J. P. B.; Peeper, D. S.; Possik, P. A.
10.1101/2025.01.14.632956 — cancer biology — Posted on 2025-01-17
2588 Instantly Reversible Enzyme Regulation via Dichromatic Irradiation of Incorporated Azobenzene
Lahmy, R.; Hiefinger, C.; Zeqiri, F.; Mandl, S.; Stockerl, W.; Gschwind, R. M.; Koenig, B.; Hupfeld, A.
10.1101/2024.07.04.602025 — biophysics — Posted on 2025-01-17
2589 GPU-accelerated homology search with MMseqs2
Kallenborn, F.; Chacon, A.; Hundt, C.; Sirelkhatim, H.; Didi, K.; Cha, S.; Dallago, C.; Mirdita, M.; Schmidt, B.; Steinegger, M.
10.1101/2024.11.13.623350 — bioinformatics — Posted on 2025-01-17
2594 Implementation of a Clostridium luticellarii genome-scale model for upgrading syngas fermentations
Scott, W. T.; Rockx, S.; Mariën, Q.; Regueira Lopez, A.; Candry, P.; Ganigue, R.; Koehorst, J. J.; Schaap, P. J.
10.1101/2024.11.26.625427 — systems biology — Posted on 2025-01-17
2597 Time-resolved immune dynamics in rheumatoid arthritis under Methotrexate therapy
Preglej, T.; Tosevska, A.; Brinkmann, M.; Schatzlmaier, P.; Simader, E.; Sieghart, D.; Hofer, P.; Krausgruber, T.; Dobnikar, L.; Bock, C.; Karonitsch, T.; Kain, R.; Ellmeier, W.; Aletaha, D.; Goeschl, L.; Bonelli, M.
10.1101/2025.01.14.629357 — genomics — Posted on 2025-01-17
2599 MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migration
Xu, P.; Zhang, R.; Zhou, Z.; Xu, H.; Li, Y.; Yang, M.; Lin, R.; Wang, Y.; Huang, X.; Xie, Q.; Meng, W.
10.1101/2024.05.28.596185 — cell biology — Posted on 2025-01-17
2600 Genetic analysis of Mycobacterium abscessus reveals genomic diversity linked to global plasmid distribution
Ohse, K.; Yoshida, A.; Kamada, K.; Kitazawa, H.; Ito, Y.; Shoji, T.; Watanabe, K.; Koganemaru, H.; Kikuchi, K.; Toyoda, M.
10.1101/2024.06.11.597493 — microbiology — Posted on 2025-01-17
2603 In the face of competition, imperfect knowledge can lead to sustainable exploitation of a shared resource.
Aarts, G.; Fieberg, J.; Richter, A.; Poos, J. J.; Hintzen, N. T.; Bijleveld, A. I.; Hengeveld, G. M.; van Kooten, T.; van Leeuwen, A.; Matthiopoulos, J.; Van Langevelde, F.; Riotte-Lambert, L.
10.1101/2025.01.16.633107 — ecology — Posted on 2025-01-17
2604 Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease
Crnkovic, S.; Thekkekara Puthenparampil, H.; Mulch, S.; Biasin, V.; Radic, N.; Wilhelm, J.; Bartkuhn, M.; Bonyadi Rad, E.; Wawrzen, A.; Matzer, I.; Mitra, A.; Leib, R. D.; Nagy, B. M.; Sahu-Osen, A.; Valzano, F.; Bordag, N.; Evermann, M.; Hoetzenecker, K.; Olschewski, A.; Ljubojevic-Holzer, S.; Wygrecka, M.; Stenmark, K.; Marsh, L. M.; de Jesus Perez, V.; Kwapiszewska, G.
10.1101/2024.05.15.594343 — cell biology — Posted on 2025-01-17
2608 Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001
Manchanda, Y.; Jones, B.; Carrat, G.; Ramchunder, Z.; Marchetti, P.; Leclerc, I.; Thennati, R.; Burade, V.; Natarajan, M.; Shahi, P.; Tomas, A.; Rutter, G. A.
10.1101/2025.01.13.632834 — pharmacology and toxicology — Posted on 2025-01-17
2610 Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance
Gupta, A.; Choueiry, F.; Reardon, J.; Pramod, N.; Kulkarni, A.; Shankar, E.; Sizemore, S.; Stover, D.; Zhu, J.; Ramaswamy, B.; Majumder, S.
10.1101/2025.01.16.633236 — cancer biology — Posted on 2025-01-17
2616 SH2D2A is an indicator of favourable prognosis in bladder cancer and is enriched in Treg cells
Gilmour, B. C.; Visser, J. G.; Kohn-Luque, A.; Lossius, A.; Borowicz, P.; Spurkland, A.
10.1101/2025.01.13.632739 — bioinformatics — Posted on 2025-01-17
2617 Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant
Yang, B.; Rutkowski, N.; Ruta, A.; Gray-Gaillard, E.; Maestas, D. R.; Kelly, S. H.; Krishnan, K.; Wu, X.; Wu, S.; Chen, A. M.; Amelung, C. D.; Mejias, J. C.; Hooks, J. S. T.; Vanderzee, I.; Mensah, P.; Celik, N.; Eric, M.; Abraham, P.; Tam, A.; Gerecht, S.; Housseau, F.; Pardoll, D. M.; Sears, C.; Elisseeff, J.
10.1101/2025.01.13.632473 — bioengineering — Posted on 2025-01-17
2618 Multi-center benchmarking of cervical spinal cord RF coils for 7 T MRI: A traveling spines study
Alonso-Ortiz, E.; Papp, D.; Barry, R. L.; Poeti, K.; Seifert, A. C.; Gilbert, K. M.; Rios, N. M. L.; Paska, J.; Eippert, F.; Weiskopf, N.; Beghini, L.; Graedel, N.; Trampel, R.; Callaghan, M. F.; Aigner, C.; Freund, P.; Seif, M.; Destruel, A.; Callot, V.; Vannesjo, J.; Cohen-Adad, J.
10.1101/2025.01.13.632825 — bioengineering — Posted on 2025-01-17
2620 ERGA-BGE genome of Pinctada radiata (Leach, 1814): one of the first Lessepsian migrants
Vasileiadou, K.; Manousaki, T.; Dailianis, T.; Skouradakis, G.; Vernadou, E.; Karakasi, D.; Bohne, A.; Monteiro, R.; Fernandez, R.; Escudero, N.; Sequencing Team, G.; Moussy, A.; Cruaud, C.; Labadie, K.; Demirdjian, L.; Istace, B.; Couloux, A.; Wincker, P.; Oliveira, P. H.; Aury, J.-M.; Bortoluzzi, C.
10.1101/2025.01.17.632165 — genomics — Posted on 2025-01-17
2626 Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3
Hennes, E.; Lucas, B.; Scholes, N. S.; Cheng, X.-f.; Scott, D. C.; Bischoff, M.; Reich, K.; Gasper, R.; Lucas, M.; Xu, T. T.; Pulvermacher, L.-M.; Doetsch, L.; Imrichova, H.; Brause, A.; Naredla, K. R.; Sievers, S.; Kumar, K.; Janning, P.; Gersch, M.; Murray, P. J.; Schulmann, B. A.; Winter, G. E.; Ziegler, S.; Waldmann, H.
10.1101/2024.07.10.602857 — cell biology — Posted on 2025-01-17
2628 Diel changes in the expression of a marker gene and candidate genes for intracellular amorphous CaCO3 biomineralization in Microcystis
Bruley, A.; Gaëtan, J.; Gugger, M.; Pancrace, C.; Millet, M.; Gaschignard, G.; Dezi, M.; Humbert, J.-F.; Leloup, J.; Skouri-Panet, F.; Callebaut, I.; Benzerara, K.; Duprat, E.
10.1101/2024.07.07.602159 — microbiology — Posted on 2025-01-17
2629 Longitudinal T cell repertoire analysis reveals dynamic clonal T cell populations in Ulcerative Colitis
Briggs, K. C.; Lin, J. S.; Chaaban, L.; Parian, A.; Lazarev, M.; Selaru, F. M.; Housseau, F.; Smith, K. N.; Melia, J. M.
10.1101/2025.01.13.632427 — immunology — Posted on 2025-01-17
2630 Unintended bias in the pursuit of collinearity solutions in fMRI analysis
Mumford, J. A.; Demidenko, M. I.; Bjork, J. M.; Chaarani, B.; Feczko, E. J.; Garavan, H. P.; Hagler, D. J.; Nelson, S. M.; Wager, T. D.; Poldrack, R. A.
10.1101/2025.01.14.633053 — neuroscience — Posted on 2025-01-17
2631 An amygdala-cortical circuit for encoding generalized fear memories.
Vincent, C. J.; Aguilar-Alvarez, R.; Vanderhoof, S. O.; Mott, D. D.; Jasnow, A. M.
10.1101/2025.01.15.633190 — neuroscience — Posted on 2025-01-17
2633 Subthalamic Signature of Freezing of Gait in Parkinson Disease
Collomb-Clerc, A.; Yeche, M.; Demain, A.; Van Hamme, A.; Olivier, C.; Belaid, H.; Ziri, D.; Derrey, S.; Fernandez-Vidal, S.; Lehongre, K.; Karachi, C.; Lau, B.; Welter, M.-L.
10.1101/2025.01.10.632393 — neuroscience — Posted on 2025-01-17
2634 Muscle Strength and Size Relationships with Unilateral Progressive Resistance Training
Deiwert, D. D.; Ma, S.; Carey, C.; Greenwell, D.; Gordish-Dressman, H.; Thompson, P. D.; Price, T.; Angelopoulos, T. J.; Clarkson, P. M.; Gordon, P. M.; Moyna, N. M.; Pescatello, L. S.; Visich, P. S.; Zoeller, R. F.; Hoffman, E. P.; Hubal, M. J.
10.1101/2025.01.13.632853 — physiology — Posted on 2025-01-17
2635 Cytosolic transport of citrate protects nutrient-austere pancreatic cancer from ferroptosis
Kneebone, A.; Lindaur, K.; Abbas, A.; Cassel, J.; Graff, S.; Abood, G.; Ding, X.; Small, W.; Tatsuoka, C.; Sidoli, S.; Salvino, J. M.; Vaziri-Gohar, A.
10.1101/2025.01.15.633097 — cancer biology — Posted on 2025-01-17
2638 GenVarLoader: An accelerated dataloader for applying deep learning to personalized genomics
Laub, D.; Ho, A.; Jaureguy, J.; Klie, A.; Salem, R. M.; McVicker, G.; Carter, H.
10.1101/2025.01.15.633240 — genomics — Posted on 2025-01-17
2639 Role of X chromosome and dosage compensation mechanisms in complex trait genetics
Fu, Y.; Kenttamies, A.; Ruotsalainen, S. E.; Pirinen, M.; Tukiainen, T.
10.1101/2025.01.16.633321 — genetics — Posted on 2025-01-17
2642 Specific and redundant roles for Gli2 and Gli3 in establishing cell fate during hair follicle development
Gozum, G.; Wirtz, L.; Damen, M.; Reckert, V.; Schettina, P.; Nelles, M.; Bazzi, H.; Niemann, C.
10.1101/2025.01.14.632991 — cell biology — Posted on 2025-01-17
2645 Integrated single-cell analyses of affinity-tested B-cells enable the identification of a gene signature to predict antibody affinity.
Chirichella, M.; Ratcliff, M.; Gu, S.; Miragaia, R.; Sammito, M.; Cutano, V.; Cohen, S.; Angeletti, D.; Romero-Ros, X.; Schofield, D. J.
10.1101/2025.01.15.633143 — immunology — Posted on 2025-01-17
2646 Stimulus-driven cerebrospinal fluid dynamics is impaired in glaucoma patients
Bang, J. W.; Parra, C.; Yu, K.; Lee, H. S.; Wollstein, G.; Schuman, J. S.; Chan, K. C.
10.1101/2025.01.15.633258 — neuroscience — Posted on 2025-01-17
2647 EEG Responses to Exercise Intensity in Parkinson's Disease
Alizadeh, Z.; Arasteh, E.; Mirian, M. S.; Murray, D.; Sacheli, M.; Cresswell, S.; McKeown, M.
10.1101/2025.01.15.633102 — neuroscience — Posted on 2025-01-17
2648 Detection of alpha synuclein seeding activity in tear fluid in patients with Parkinson's disease
Canaslan, S.; Schmitz, M.; Maass, F.; Hermann, P.; da Silva Correia, S.; Zhang, S.; van Riesen, C.; Parchi, P.; Lingor, P.; Zerr, I.
10.1101/2025.01.16.633314 — neuroscience — Posted on 2025-01-17
2649 Impaired glymphatic clearance independently contributes to poor outcomes in Parkinsons disease
Zarkali, A.; Thomas, G. E. C.; Patterson, R.; Hannaway, N.; Dobreva, I.; Heslegrave, A.; Veleva, E.; Zetterberg, H.; Weil, R. S.
10.1101/2025.01.15.633106 — neuroscience — Posted on 2025-01-17
2651 Matrix stiffness modulated release of spheroid-derived extracellular vesicles and discovery of Piezo1 cargo
Sheth, M.; Sharma, M.; Kongsomros, S.; Lehn, M.; Takebe, T.; Takiar, V.; Wise-Draper, T.; Chutipongtanate, S.; Esfandiari, L.
10.1101/2025.01.13.632826 — cancer biology — Posted on 2025-01-17
2652 Cross-modality representation and multi-sample integration of spatially resolved omics data
Li, Z.; Cui, X.; Chen, X.; Gao, Z.; Liu, Y.; Pan, Y.; Chen, S.; Lv, H.; Zhai, L.; Jiang, R.
10.1101/2024.06.10.598155 — bioinformatics — Posted on 2025-01-17
2653 Cardiac fibrosis inhibitor CTPR390 prevents structural and morphological changes in collagen and fibroblasts of engineered human connective tissue
Maestro, D.; Palanca, A.; Llarena, I.; DeGrave, A. N.; Guedes, G.; de Oliveira, G. H.; Coelho Conceicao, A. L.; Mieites, V.; Icardo De La Escalera, J. M.; Sanchez-Cano, C.; Conde, O. M.; Lutz, S.; Cortajarena, A. L.; Villar, A. V.
10.1101/2025.01.15.633162 — biochemistry — Posted on 2025-01-17
2654 Human and Rodent Seizures Demonstrate a Dynamic Interplay with Spreading Depolarizations
Norby, J. H.; Hummel, D.; Ricks, N.; Rolston, J. D.; Rahimpour, S.; Voipio, J.; Trevelyan, A. J.; Smith, E. H.; Parrish, R. R.
10.1101/2025.01.16.633405 — neuroscience — Posted on 2025-01-17
2656 Misspelled-word reading modulates late cortical dynamics
You, J.; Saranpaa, A.; Lindh-Knuutila, T.; Vliet, M. v.; Salmelin, R.
10.1101/2025.01.05.631357 — neuroscience — Posted on 2025-01-17
2657 Exon inclusion signatures enable accurate estimation of splicing factor activity
Anglada-Girotto, M.; Moakley, D. F.; Zhang, C.; Miravet-Verde, S.; Califano, A.; Serrano, L.
10.1101/2024.06.21.600051 — systems biology — Posted on 2025-01-17
2661 Modeling human limb skeletal development using human pluripotent stem cell-derived skeletal assembloids
Takao, T.; Osone, T.; Sato, K.; Yamada, D.; Fujisawa, Y.; Hagiwara, M.; Nakata, E.; Ozaki, T.; Toguchida, J.; Takarada, T.
10.1101/2025.01.09.631479 — bioengineering — Posted on 2025-01-17
2666 Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors
Gongwer, M. W.; Etienne, F.; Moca, E. N.; Chappell, M. S.; Blagburn-Blanco, S. V.; Riley, J. P.; Enos, A. S.; Haratian, M.; Qi, A.; Rojo, R.; Wilke, S. A.; Pridans, C. A.; DeNardo, L. A.; De Biase, L. M.
10.1101/2025.01.15.633068 — neuroscience — Posted on 2025-01-16
2669 The evolution of pectate lyase-like genes across land plants, and their roles in haustorium formation in parasitic plants
Zhang, H.; Wafula, E. K.; Kelly, E. M.; Ko, I.; Yocca, A.; Bandaranayake, P. C. G.; Yang, Z.; Yoder, J.; Honaas, L.; dePamphilis, C.
10.1101/2024.12.04.626843 — plant biology — Posted on 2025-01-16
2670 A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins
Kelpsch, D. J.; Zhang, L.; Thierer, J. H.; Koren, K.; Kumar, U.; Lin, Y.; Hensley, M. R.; Sohn, M.; Liu, J. O.; Lectka, T.; Mumm, J. S.; Farber, S. A.
10.1101/2024.11.14.623618 — physiology — Posted on 2025-01-16
2671 Genetic Mapping of All Human Paralog Pairs to Characterize Synthetic Lethality and Buffering
Flister, M. J.; Verduzco, D.; Petiwala, S.; Carneiro-Lobo, T. C.; Ghekas, C.; Shi, X.; Lu, C.; Dezso, Z. J.
10.1101/2024.07.16.603642 — cancer biology — Posted on 2025-01-16
2672 Characterizing the Solution Space of Migration Histories of Metastatic Cancers with MACH2
Roddur, M. S.; Ramavarapu, V.; Bunkum, A.; Huebner, A.; Mineyev, R.; McGranahan, N.; Zaccaria, S.; El-Kebir, M.
10.1101/2024.11.19.624301 — cancer biology — Posted on 2025-01-16
2673 Community assembly modeling of microbial evolution within Barrett's esophagus and esophageal adenocarcinoma
Guccione, C.; Sfiligoi, I.; Gonzalez, A.; Shaffer, J. P.; Kazachkova, M.; Weng, Y.; McDonald, D.; Shah, S. C.; Minot, S. S.; Paulson, T. G.; Grady, W. M.; Alexandrov, L. B.; Knight, R.; Curtius, K.
10.1101/2025.01.14.633020 — cancer biology — Posted on 2025-01-16
2674 In situ light-driven pH modulation for NMR studies
Barde, A.; Han, R.; Olson, M. A.; Tonelli, M.; Rienstra, C. M.; Henzler-Wildman, K.; Ravula, T.
10.1101/2025.01.16.633412 — biochemistry — Posted on 2025-01-16
2675 Optimizing mouse metatranscriptome profiling by selective removal of redundant nucleic acid sequences
Kuersten, S.; Roos, M.; Tan, A.; Bunga, S.; Skola, D.; Conrad, R.; Maissy, E. S.; Richter, A.; Desplats, P.; Whittaker, D. S.; Zarrinpar, A.
10.1101/2025.01.15.632452 — genomics — Posted on 2025-01-16
2678 Breeding of microbiomes conferring salt tolerance to plants
Pereira, C. G.; Edwards, J. A.; Khasanova, A.; Carlson, A. L.; Brisson, V.; Schaefer, E.; Glavina del Rio, T.; Tringe, S.; Vogel, J. P.; Des Marais, D. L.; Juenger, T. E.; Mueller, U. G.
10.1101/2025.01.13.632835 — evolutionary biology — Posted on 2025-01-16
2680 The Alexander Disease Protein GFAP Drives Mitochondrial Fission
XIONG, D.; KONG, L.; Tan, Y. S.; YUAN, F.; SUN, Z.; LI, X.; ABELLA, E.; MESSING, A.; Zhang, S.-C.
10.1101/2024.02.20.581117 — cell biology — Posted on 2025-01-16
2684 Development of conditional-siRNA programmable riboswitch for targeting adverse cardiac remodeling
Gokulnath, P.; Salvador, A. M.; Graham, C.; Han, S.-p.; Li, G.; Kannappan, R.; Azzam, C.; Spanos, M.; Scherer, L.; Sethu, P.; Rossi, J.; Goddard, W. A.; Das, S.
10.1101/2025.01.16.633434 — molecular biology — Posted on 2025-01-16
2686 Molecular circuit between Aspergillus nidulans transcription factors MsnA and VelB to coordinate fungal stress and developmental responses
Bastakis, E.; Gerke, J.; Ozkan, S.; Harting, R.; Lienard, T.; Sasse, C.; Xylakis, E. S.; Aden, M.; Strohdiek, A.; Heinrich, G.; Grosse, V.; Braus, G. H.
10.1101/2025.01.16.633343 — microbiology — Posted on 2025-01-16
2690 Evidence of dengue virus transmission and a diverse Aedes mosquito virome on the Democratic Republic of Congo-Angola border
He, W.; Bobanga, T.; Piantadosi, A.; Popkin-Hall, Z. R.; Vulu, F.; Collins, M. H.; Kashamuka, M. M.; Tshefu, A. K.; Juliano, J. J.; Parr, J. B.
10.1101/2025.01.16.633031 — microbiology — Posted on 2025-01-16
2691 Human and Mouse Models for Kabuki Syndrome Reveal Increase in Inhibitory Synapse Development.
Knopp, J.; Weaver, A.; Miller, S.; Nomura, T.; Whitlark, A.; Swantkowski, J.; Noble, A.; Nam, S.; Hutson, K.; Bergqvist-Patzke, J.; Contractor, A.; Patzke, C.
10.1101/2024.10.04.616738 — neuroscience — Posted on 2025-01-16
2692 Viral vector-mediated SLC9A6 gene replacement reduces cerebellar dysfunction in the shaker rat model of Christianson syndrome
Anderson, C. J.; Figueroa, K. P.; Paul, S. J.; Gandelman, M.; Dansithong, W.; Katakowski, J. A.; Scoles, D. R.; Pulst, S. M.
10.1101/2024.10.31.621435 — neuroscience — Posted on 2025-01-16
2693 Facilitation of Cav3.2 channel gating in pain pathways reveals a novel mechanism of serum-induced hyperalgesia
Sanner, K.; Kawell, S.; Evans, G. J.; Elekovic, V.; Walz, M.; Joksimovic, S. L.; Joksimovic, S. M.; Donald, R. R.; Tomic, M.; Orestes, P.; Feseha, S.; Dedek, A.; Ghodsi, S. M.; Fallon, I. P.; Lee, J.; Hwang, S. M.; Hong, S. J.; Covey, D. F.; Romano, C.; Timic Stamenic, T.; Chemin, J.; Bourinet, E.; Poulen, G.; Lonjon, N.; Vachiery-Lahaye, F.; Bauchet, L.; Zorumski, C. F.; Mayer, J. P.; Stowell, M. H. B.; Hildebrand, M. E.; Eisenmesser, E. Z.; Jevtovic-Todorovic, V.; Todorovic, S. M.
10.1101/2025.01.03.631165 — neuroscience — Posted on 2025-01-16
2696 The oncogenic CCDC6-RET fusion product is a dual ATP and ADP-dependent kinase that functions via cis-phosphorylation
Martin-Hurtado, A.; Contreras, J. C.; Sanchez-Wandelmer, J.; Zarzuela, E.; Munoz, I. G.; Munoz, J.; Isasa, M.; Plaza-Menacho, I.
10.1101/2025.01.14.632894 — biochemistry — Posted on 2025-01-16
2697 A novel inhibitor against the bromodomain PfBDP1 of the malaria pathogen Plasmodium falciparum
Amann, M.; Warstat, R.; Rechten, K. K.; Theuer, P.; Schustereder, M.; Clavey, S.; Breit, B.; Einsle, O.; Huegle, M.; Petter, M.; Guenther, S.
10.1101/2025.01.16.633141 — biochemistry — Posted on 2025-01-16
2699 Mechanism of RPA phosphocode priming and tuning by Cdk1/Wee1 signaling circuit
Roshan, P.; Kaushik, V.; Mistry, A.; Vayyeti, A.; Antony, A.; Lubbers, R.; Deveryshetty, J.; Antony, E.; Origanti, S. S.
10.1101/2025.01.16.633180 — biochemistry — Posted on 2025-01-16
2700 Urban crops demonstrate comparable potential for organic carbon storage as natural ecosystems.
Prieto, B. J.; Garcia-Palacios, P.; Lorenzo, C.; Elena Aguilar-Santana, E.; Algora, C.; Bastida, F.; Calvo, L.; Nuria Casado Coy, N.; Campos-Castro, A.; Centenaro, G.; Chamizo, S.; Costa, J. C.; Santiago Martin-Bravo, S.; Manuel Delgado-Baquerizo, M.; Dashevskaya, S.; Carmona-Yanez, M. D.; Duran Humia, J.; Fernandez-Alonso, M. J.; Figueira, D.; Garcia, E.; G. Alday, J.; G. de la Riva, E.; Ladron de Guevara, M.; Lopez-Velasco, A.; Lucas-Borja, M. E.; Prieto Aguilar, I.; Perez-LOpez, J.; Plaza-Alvarez, P. A.; Rodriguez Pereiras, A.; Sanz-Lazaro, C.; Soliveres, S.; Terrones, A.; Torres, A.; Leo,
10.1101/2025.01.15.633129 — biochemistry — Posted on 2025-01-16
2702 Creation and Validation of a Proteome-Wide Yeast Library for Protein Detection and Analysis
Baruch, D.; Tsirkas, I.; Sass, E.; Dubreuil, B.; Asraf, Y.; Aharoni, A.; Schuldiner, M.; Klein, O.
10.1101/2025.01.14.632936 — molecular biology — Posted on 2025-01-16
2703 Functional Characterization of a Novel Long Non-Coding RNA in Leishmania braziliensis Identified Through Computational Screening for Conserved RNA Structures
Espada, C. R.; Anthon, C.; Magalhaes, R. D. M.; Quilles Junior, J. C.; Teles, N. M. M.; Pais, F. S.; Orsine, L. A.; de Almeida, L.; Defina, T. P. A.; Dowle, A.; Gorodkin, J.; Walrad, P. B.; Cruz, A. K.
10.1101/2025.01.14.632970 — molecular biology — Posted on 2025-01-16
2705 Environmental factors drive bacterial degradation of gastrointestinal mucus
Arias, S. L.; van Wijngaarden, E. W.; Balint, D.; Jones, J.; Crawford, C. C.; Shukla, P. J.; Silberstein, M.; Brito, I. L.
10.1101/2025.01.16.633397 — microbiology — Posted on 2025-01-16
2706 Rhizosphere-colonizing bacteria persist in the protist microbiome
Taerum, S. J.; Patel, R. R.; Alamo, J.; Gage, D. J.; Steven, B.; Triplett, L. R.
10.1101/2025.01.16.633413 — microbiology — Posted on 2025-01-16
2707 A multilamellar organelle for chemosymbiosis in an aplacophoran mollusc adapted to anoxic cold seep sediment
Li, Y.; Chen, C.; Liu, X.; Li, M.; Zhou, H.; Wang, H.; Zheng, X.; He, X.; Liu, S.; Qiu, J.-W.; Qian, P.-Y.; Sun, J.
10.1101/2025.01.16.633305 — microbiology — Posted on 2025-01-16
2708 Investigation of Bile Salt Hydrolase Activity in Human Gut Bacteria Reveals Production of Conjugated Secondary Bile Acids
Lucas, L. N.; Jillella, M.; Cattaneo, L. E.; Gangwar, B.; Zhang, Q.; Kerby, R. L.; Stevenson, D. M.; Rey, F. E.; Amador-Noguez, D.
10.1101/2025.01.16.633392 — microbiology — Posted on 2025-01-16
2709 The role of lipoteichoic acid in Staphylococcus aureus cell wall integrity
Bae, T.; Kanampalliwar, A.; Shah, M. A.; Park, Y.; Jeong, B.; LAWSON, P. A.; Bell, M.; Fesko, E. M.; Sainato, A.; Sainato, D.; Walker, S.
10.1101/2025.01.16.633316 — microbiology — Posted on 2025-01-16
2710 Technical and biological sources of noise confound multiplexed enhancer AAV screening
Hunker, A. C.; Mich, J. K.; Taskin, N.; Torkelson, A.; Pham, T.; Bertagnolli, D.; Chakka, A. B.; Chakrabarty, R.; Donadio, N. P.; Ferrer, R.; Gasperini, M.; Goldy, J.; Guzman, J.; Jin, K.; Khem, S.; Kutsal, R.; Lalanne, J.-B.; Martinez, R. A.; Newman, D.; Pena, N.; Shapovalova, N. V.; Weed, N.; Zhou, T.; Yao, S.; Shendure, J.; Smith, K. A.; Lein, E. S.; Tasic, B.; Levi, B. P.; Ting, J. T.
10.1101/2025.01.14.633018 — neuroscience — Posted on 2025-01-16
2712 Sequential visual stimuli increase high frequency power in the visual cortex
Keil, J.; Hernandez-Urbina, V.; Vassiliou, C.; Dean, C.; Schmitz, D.; Kremkow, J.; Sibille, J.
10.1101/2025.01.14.632930 — neuroscience — Posted on 2025-01-16
2713 Preclinical Evaluation of P4B-2412 as Phosphodiesterase 4B Radioligand for Positron Emission Tomography Imaging
Song, Z.; Li, Y.; Feng, S.; Chen, J.; Zhou, X.; Zhang, Z.; Sun, Z.; Rong, J.; Zhao, C.; Chaudhary, A.; Patel, J. S.; Gao, Y.; Collier, T. L.; Ran, C.; Haider, A.; Yuan, H.; Liang, S. H.
10.1101/2025.01.16.633384 — neuroscience — Posted on 2025-01-16
2714 Thalamic involvement defines distinct slow-wave subtypes in NREM sleep
Bergamo, D.; Handjaras, G.; Picchioni, D.; Ricciardi, E.; Ozbay, P. S.; de Zwart, J.; Duyn, J. H.; Bernardi, G.; Betta, M.
10.1101/2025.01.16.633402 — neuroscience — Posted on 2025-01-16
2719 Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology
Vetere, L. M.; Galas, A. M.; Vaughan, N.; Feng, Y.; Christenson Wick, Z.; Philipsberg, P. A.; Liobimova, O.; Frenandez-Ruiz, A.; Cai, D. J.; Shuman, T.
10.1101/2025.01.15.633171 — neuroscience — Posted on 2025-01-16
2725 In vivo Morphological Dynamics of Single Laser-Axotomized Corneal Nerve Fibers in Sarm1-Null Adult Mice
Inigo-Portugues, A.; Aleixandre-Carrera, F.; Sala, S.; Borras, F.; Gomez-Sanchez, J. A.; Arthur-Farraj, P.; Acosta, M. C.; Belmonte, C.; Gallar, J.; Meseguer, V.
10.1101/2025.01.14.632447 — neuroscience — Posted on 2025-01-16
2726 Human and Rodent Seizures Demonstrate a Dynamic Interplay with Spreading Depolarizations
Norby, J. H.; Hummel, D.; Rolston, J. D.; Rahimpour, S.; Voipio, J.; Trevelyan, A. J.; Smith, E. H.; Parrish, R. R.
10.1101/2025.01.16.633405 — neuroscience — Posted on 2025-01-16
2731 Experience-dependent reorganization of inhibitory neuron synaptic connectivity
Fink, A. J. P.; Muscinelli, S.; Wang, S.; Hogan, M. I.; English, D. F.; Axel, R.; Litwin-Kumar, A.; Schoonover, C. E.
10.1101/2025.01.16.633450 — neuroscience — Posted on 2025-01-16
2732 Intestinal stem cell marker MEX3A regulates PPARγ expression with functional impact in colorectal carcinogenesis
Silva, A. R.; Coelho, A.; Machado, V.; Russel, M.; Mexieiro, D.; Amaral, A. L.; Cavadas, B.; Carvalho-Maia, C.; Gigliano, D.; Jeronimo, C.; Almeida, R.; Pereira, B.
10.1101/2025.01.13.632758 — cancer biology — Posted on 2025-01-16
2733 Site-specific immunogenicity and anti-PD1 response in mismatch repair deficient lung adenocarcinoma models
Abad, E.; Zadra, I.; Krasko, A.; Subirana, M.; Reyes, D.; Borredat, P.; Pasquali, L.; Aramburu, J.; Lopez, C.; Janic, A.
10.1101/2025.01.13.632715 — cancer biology — Posted on 2025-01-16
2735 SwarmMAP: Swarm Learning for Decentralized Cell Type Annotation in Single Cell Sequencing Data
Goepp, V.; Saldanha, O. L.; Pfeiffer, K.; Kim, H.; Kramann, R.; Hayat, S.; Kather, J. N.
10.1101/2025.01.13.632775 — bioinformatics — Posted on 2025-01-16
2742 Repeated tDCS at clinically-relevant field intensity can boost concurrent motor learning in rats.
Farahani, F.; Voroslakos, M.; Birnbaum, A. M.; FallahRad, M.; Williams, P. T. J. A.; Martin, J. H.; Parra, L. C.
10.1101/2025.01.15.633248 — animal behavior and cognition — Posted on 2025-01-16
2744 Three species, three labs, three experiments: testing the reproducibility of ecological studies on insect behaviour in a multi-laboratory setting
Mundinger, C.; Schulz, N. K. E.; Singh, P.; Janz, S.; Schurig, M.; Seidemann, J.; Kurtz, J.; Muller, C.; Schielzeth, H.; von Kortzfleisch, V. T.; Richter, S. H.
10.1101/2025.01.16.633334 — animal behavior and cognition — Posted on 2025-01-16
2745 Multilayer regulation underlies the functional precision and evolvability of the olfactory system
Mermet, J.; Cruchet, S.; Borbora, A. S.; Lee, D.; Chai, P. C.; Jang, A.; Menuz, K.; Benton, R.
10.1101/2025.01.16.632932 — developmental biology — Posted on 2025-01-16
2747 NimA promotes cell adhesion at the blood brain barrier of Drosophila nervous system
Sakr, R.; Monticelli, S.; Delaporte, C.; Zhang, G.; Tabiat, T.; Giangrande, A.; Cattenoz, P. B.
10.1101/2025.01.15.633121 — developmental biology — Posted on 2025-01-16
2749 TimeFlies: an snRNA-seq aging clock for the fruit fly head sheds light on sex-biased aging
Tennant, N.; Pavuluri, A.; O'Connor-Giles, K. M.; Singh, G.; Larschan, E.; Singh, R.
10.1101/2024.11.25.625273 — genomics — Posted on 2025-01-16
2752 Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids
Calubag, M. F.; Ademi, I.; Grunow, I.; Breuer, L.; Babygirija, R.; Lialios, P.; Le, S.; Minton, D. M.; Sonsalla, M. M.; Illiano, J.; Knopf, B. A.; Xiao, F.; Konopka, A. R.; Harris, D. A.; Lamming, D. W.
10.1101/2025.01.13.632607 — physiology — Posted on 2025-01-16
2753 Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with in Vivo Anti-alphaviral Activity
Hossain, M. A.; Mayo, A. K.; Ghoshal, A.; Taft-Benz, S. A.; Anderson, E. J.; Morales, N. L.; Pressey, K. D.; Vargason, A. M.; Brouwer, K. L. R.; Moorman, N. J.; Heise, M. T.; Willson, T. M.
10.1101/2025.01.13.632788 — pharmacology and toxicology — Posted on 2025-01-16
2754 Targeting anemia-induced CD71+ reticulocytes protects mice from Plasmodium infection
Zeydabadinejad, S.; Kim, J. S. A.; Zheng, A.; Kandalgaonkar, M. R.; Ababio, P. B.; Vijay-Kumar, M.; Yeoh, B. S.; Saha, P.
10.1101/2025.01.13.632761 — pathology — Posted on 2025-01-16
2763 A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins
Kelpsch, D. J.; Zhang, L.; Thierer, J. H.; Koren, K.; Kumar, U.; Lin, Y.; Hensley, M. R.; Sohn, M.; Liu, J. O.; Lectka, T.; Mumm, J. S.; Farber, S. A.
10.1101/2024.11.14.623618 — physiology — Posted on 2025-01-16
2764 Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer.
Toh, Y.; Wu, L.; Tu, J.; Liang, Z.; Aldana, A. M.; Wen, J. J.; Li, L.; Pan, S.; Rowe, J. H.; Hensel, M. E.; Hodo, C. L.; Finch, R. A.; Carmon, K. S.; Liu, Q. J.
10.1101/2024.10.08.616548 — pharmacology and toxicology — Posted on 2025-01-16
2765 Monitoring monomer-specific acyl-tRNA levels in cells with PARTI
Pressimone, M. A.; Schissel, C. K.; Goss, I. H.; Swenson, C. V.; Schepartz, A.
10.1101/2025.01.14.633079 — biochemistry — Posted on 2025-01-16
2768 The T3SS structural and effector genes of Chlamydia trachomatis are expressed in distinct phenotypic cell forms.
Grieshaber, N.; Appa, C. R.; Ward, M.; Grossman, A.; McCormik, S.; Grieshaber, B. S.; Chiarelli, T. J.; Yang, H.; Omsland, A.; Grieshaber, S. S.
10.1101/2024.04.25.591156 — microbiology — Posted on 2025-01-16
2769 Reciprocal interactions between CA1 pyramidal and axo-axonic cells control sharp wave-ripple events
Gilbert, E. T.; Klaver, L. M. F.; Arndt, K. C.; Kim, J.; Jia, X.; McKenzie, S.; English, D. F.
10.1101/2024.07.02.601726 — neuroscience — Posted on 2025-01-16
2771 Behavior decoding delineates seizure microfeatures and associated sudden death risks in mice
Shen, Y.; Thomas, J.; Chen, X.; Zelidon, J.; Hahn, A.; Sathyanesan, A.; Zhang, P.; Gu, B.
10.1101/2025.01.13.632867 — neuroscience — Posted on 2025-01-16
2772 Linalool and trans-nerolidol prevent pentylenetetrazole-induced seizures in adult zebrafish
Silva, A. L.; Bastos, L. M.; Gallas-Lopes, M.; Chitolina, R.; Reis, C. G.; Nunes, D. S.; Elisabetsky, E.; Herrmann, A. P.; Calcagnotto, M. E.; Piato, A.
10.1101/2025.01.14.633001 — neuroscience — Posted on 2025-01-16
2774 Mechanisms of P. aeruginosa resistance to Type VI Secretion System attacks
Tejada-Arranz, A.; Plack, A.; Antelo-Varela, M.; Kaczmarczyk, A.; Klotz, A.; Jenal, U.; Basler, M.
10.1101/2024.10.26.620397 — microbiology — Posted on 2025-01-16
2777 SRSF3 is a key regulator of epicardial formation
Lupu, I.-E.; Bruche, S.; Chakrabarti, A. M.; McCracken, I. R.; Carsana, T.; Redpath, A. N.; Smart, N.
10.1101/2021.11.25.470003 — developmental biology — Posted on 2025-01-16
2781 Redistribution of proteasomes through diffusion and cytoskeleton-dependent mechanisms upon stress induced by protein aggregates
Morten, M. J.; Zhang, Y.; Li, B.; Meng, J. X.; Jiang, K.; Sirvio, L.; Lee, J. E.; Lippert, A. H.; Burridge, M.; Pulgar Prieto, K. D.; Carr, A. R.; Ponjavic, A.; Lee, S. F.; Finley, D.; Klenerman, D.; Ye, Y.
10.1101/487702 — biophysics — Posted on 2025-01-16
2782 Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4
Ekundayo, B.; Arullampalam, P.; Gerber, C.; Haemmerli, A.-F.; Guichard, S.; Boukenna, M.; Ross-Kaschitza, D.; Lochner, M.; Rougier, J.-S.; Stahlberg, H.; Abriel, H.; Ni, D.
10.1101/2024.01.22.576650 — biochemistry — Posted on 2025-01-16
2783 Reducing spatial heterogeneity in coverage improves the effectiveness of dog vaccination campaigns against rabies
Ferguson, E.; Lugelo, A.; Czupryna, A.; Anderson, D.; Lankester, F.; Sikana, L.; Dushoff, J.; Hampson, K.
10.1101/2024.10.03.616420 — ecology — Posted on 2025-01-16
2784 A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses
Van Loy, B.; Pujol, E.; Kamata, K.; Lee, X. Y.; Bakirtzoglou, N.; Van Berwaer, R.; Vandeput, J.; Mestdagh, C.; Persoons, L.; De Wijngaert, B.; Goovaerts, Q.; Noppen, S.; Jacquemyn, M.; Ahmadzadeh, K.; Bernaerts, E.; Martin-Lopez, J.; Escriche, C.; Vanmechelen, B.; Krasniqi, B.; Singh, A. K.; Daelemans, D.; Maes, P.; Matthys, P.; Dehaen, W.; Rozenski, J.; Das, K.; Voet, A.; Vazquez, S.; Naesens, L. M.; Stevaert, A.
10.1101/2024.09.09.611961 — microbiology — Posted on 2025-01-16
2786 A Burst-dependent Thalamocortical Substrate for Perceptual Awareness
Whyte, C. J.; Muller, E. J.; Aru, J.; Larkum, M.; John, Y.; Munn, B. R.; Shine, J. M.
10.1101/2023.07.13.548934 — neuroscience — Posted on 2025-01-16
2787 The splicing factor kinase SRPK1 is a therapeutic target for Peripheral Vascular Disease
Bhalla, S. R.; Wahid, M.; Amartey, J.; Zawia, A.; Riu, F.; Gao, Y.; Agrawal, J.; Lynch, A. P.; Machado, M. J.; Hawtrey, T.; Kikuchi, R.; Green, K. R.; Teboul, L.; Allen, C.; Blackley, Z.; Rajaji, K.; Marsden, D.; Batson, J.; Harper, S. J.; Oltean, S.; Amoaku, W.; Benest, A. V.; Morris, J. C.; Braithwaite, B.; Bates, D. O.
10.1101/2024.04.17.589996 — physiology — Posted on 2025-01-16
2788 YAP engages RIF1 to dampen replication stress in squamous cell carcinoma.
Bojko, J.; Flynn, B.; Aschenbrenner, B.; Howard, A.; Lay, E.; Krajic, N.; Bailey, E.; Catalan, S.; Gallacher, K.; Sins, E.; Wang, J. A.; Jungwirth, U.; Lichtenberger, B. M.; Walko, G.
10.1101/2024.12.20.629444 — cancer biology — Posted on 2025-01-16
2789 Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targeting
Yadollahi, P.; McCord, K. A.; Li, Y.; Dayoub, H.; Saab, K.; Essien, F. N.; Hyslop, S.; Kan, E.; Ahmed, M. K.; Kirby, P. R.; Putluri, V.; Ambati, C.; Kami Reddy, R. K.; Castro, P. D.; Skinner, H. D.; Coarfa, C.; Decker, W. K.; Osman, A. A.; Patel, R. U.; Myers, J. N.; Lai, S. Y.; Putluri, N.; Johnson, F. M.; Frederick, M. J.; William, H. H.; Sandulache, V. C.
10.1101/2025.01.10.632413 — cancer biology — Posted on 2025-01-16
2792 3D-Printing of Electroconductive MXene-based Micro-meshes in a Biomimetic Hyaluronic Acid-based Scaffold Directs and Enhances Electrical Stimulation for Neural Repair Applications.
Woods, I.; Spurling, D.; Sunil, S.; Maughan, J.; Gutierrez Gonzalez, J.; McGuire, T. K.; Leahy, L. M.; Dervan, A.; Nicolosi, V.; O'Brien, F. J.
10.1101/2024.04.05.587425 — bioengineering — Posted on 2025-01-16
2793 Chromosome-level reference genome assembly for the mountain hare (Lepus timidus)
Fekete, Z.; Absolon, D. E.; Michell, C.; Wood, J. M. D.; Goffart, S.; Pohjoismaki, J. L. O.
10.1101/2024.06.10.598177 — genomics — Posted on 2025-01-16
2795 Deletion of the moe A gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism
Escobar Doncel, A.; Patinios, C.; Campos, A.; Walter Costa, M. B.; Turkina, M. V.; Murace, M.; Staals, R. H. J.; Vignolini, S.; Dutilh, B. E.; Ingham, C.
10.1101/2025.01.13.632688 — microbiology — Posted on 2025-01-16
2796 WASp activity in macrophages prevents mechano-induced inflammation by protecting the nuclear envelope
Amadio, R.; Bracchetti, G.; Alraies, Z.; Piperno, G. M.; Rodriguez, L. L.; Maurin, M.; Conti, M.; Andolfi, L.; Castiello, M. C.; Ferrua, F.; Villa, A.; Aiuti, A.; Lennon-Dumenil, A.-M.; Benvenuti, F.
10.1101/2024.12.23.630061 — immunology — Posted on 2025-01-16
2797 Women at the receiving end: Exploring Couples' experiences of infertility challenges in Nigeria
Esan, D. T.; Nnamani, K. Q.; Olajide, A. O.; Akingbade, O.; Oluwade, D. B.; Olawade, D. B.; Ramos, C. G.
10.1101/2025.01.08.632060 — developmental biology — Posted on 2025-01-16
2799 Clinical and Taxonomic Characterization of a Novel Urinary Tract Pathogen Providencia lanzhouensis
Xiang, Y.; Dong, X.; Ma, L.; Cao, D.; Li, Y.; Jiang, X.; Xu, P.; Yuan, X.; Bi, K.; Zhang, Y.; Han, Y.; Zhang, Y.
10.1101/2025.01.14.632977 — microbiology — Posted on 2025-01-16
2801 Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations
Inchausti, L.; Bilbao, L.; Campo, V. A.; Garat, J.; Sotelo-Silveira, J.; Rinaldi, G.; Howick, V. M.; Duhagon, M. A.; G. De Gaudenzi, J.; Smircich, P.
10.1101/2025.01.14.633000 — genomics — Posted on 2025-01-16
2802 Exploring the Pathogen Profiles of Ancient Feces
Capone, D.; Holcomb, D.; Lai, A.; Reinhard, K.; Brown, J.
10.1101/2025.01.14.632942 — microbiology — Posted on 2025-01-16
2803 Role of Tad Pili during the transition from Planktonic to Biofilm State in Bradyrhizobium diazoefficiens USDA 110
Iglesias, J. A.; Colla, D.; Serrangeli, J. S.; Lozano, M. J.; Falduti, O.; Brignoli, D.; Medici, I.; Althabegoiti, M. J.; Lodeiro, A.; Abdian, P.; Paczia, N.; Becker, A.; Soler-Bistue, A.; Perez-Gimenez, J.; Mongiardini, E. J.
10.1101/2025.01.14.633045 — microbiology — Posted on 2025-01-16
2809 Deciphering landscape-scale plant cover and biodiversity from soil eDNA
Goodall, T. I.; Busi, S. B.; Griffiths, R. I.; Gweon, H. S.; Norton, L.; Read, D. S.
10.1101/2025.01.14.632973 — molecular biology — Posted on 2025-01-16
2811 Immunization with a novel RNA replicon vaccine confers long-lasting protection against H5N1 avian influenza virus in 24 bird species
Zimmer, G.; Stettler, M.; Hoby, S.; Wenker, C.; Wyss, F.; Heiderich, E.; Butticaz, L.; Ruggli, N.; Darpel, K.
10.1101/2025.01.15.633174 — microbiology — Posted on 2025-01-16
2813 Volatile Organic Compound Specialists in the Phycosphere
Padaki, V. G.; Mayali, X.; Weber, P.; Giovannoni, S.; Abraham, K.; Jacobs, K.; Collart, L.; Halsey, K.
10.1101/2024.06.14.599129 — microbiology — Posted on 2025-01-16
2815 Diel changes in the expression of a marker gene and candidate genes for intracellular amorphous CaCO3 biomineralization in Microcystis
Bruley, A.; Gaëtan, J.; Gugger, M.; Pancrace, C.; Millet, M.; Gaschignard, G.; Dezi, M.; Humbert, J.-F.; Leloup, J.; Skouri-Panet, F.; Callebaut, I.; Benzerara, K.; Duprat, E.
10.1101/2024.07.07.602159 — microbiology — Posted on 2025-01-16
2816 Endogenously expressed P2X5 includes a proportion of isoforms or transcript variants sensitive to extracellular ATP
Yang, X.-N.; Wang, D.-P.; Shen, C.-H.; Chen, X.; Yang, H.; Zhou, X.; Guo, C.-R.; Tian, Y.; Zhu, M. X.; Yu, Y.
10.1101/2025.01.10.632374 — physiology — Posted on 2025-01-16
2817 Yeast DNA Polymerase δ Proofreading Nuclease Suppresses Translesion Synthesis and Facilitates Recombination in DNA Lesion Bypass.
Jun, C.; Wang, Q.; He, J.; Zhang, Z.; Chung, J. M.; Gallagher, D. N.; Hong, X.; Rao, H.; Shim, E. Y.; Haber, J. E.; Niu, H.; Lee, S. E.
10.1101/2025.01.14.632785 — genetics — Posted on 2025-01-16
2819 Ontogeny drives stage-specific effects of a Gata1 mutation
Sommer, A.; Fischer, S.; Freyer, L.; Lallemand, Y.; Dardenne, P.; Gomez-Perdiguero, E.
10.1101/2025.01.15.633164 — developmental biology — Posted on 2025-01-16
2820 DNA-encoded Library Screening Uncovers Potent DNMT2 Inhibitors Targeting a Cryptic Allosteric Binding Site
Frey, A. F.; Schwan, M.; Weldert, A. C.; Kadenbach, V.; Kopp, J.; Nidoieva, Z.; Zimmermann, R. A.; Gleue, L.; Zimmer, C.; Joerg, M.; Friedland, K.; Helm, M.; Sinning, I.; Barthels, F.
10.1101/2025.01.15.632061 — molecular biology — Posted on 2025-01-16
2824 Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR2
Lakemeyer, M.; Latorre, R.; Blazkova, K.; Jensen, D.; Wood, H. M.; Shakil, N.; Thomas, S. C.; Saxena, D.; Malpuri, Y.; Poolman, D.; Duran de Haro, P.; Keller, L. J.; Reed, D. E.; Schmidt, B. L.; Lomax, A. E.; Bunnett, N. W.; Bogyo, M.
10.1101/2025.01.15.633241 — microbiology — Posted on 2025-01-16
2825 Self-organization of high-dimensional geometry of neural activity in culture
Nakamuta, A.; Akita, D.; Zhang, H.; Kawahara, Y.; Takahashi, H.; Teramae, J.-n.
10.1101/2025.01.14.630383 — neuroscience — Posted on 2025-01-16
2826 Stress-activated neuronal ensemble in the supramammillary nucleus stores anxiety but not memory
Zhang, J.; Yu, K.; Zhang, J.; Chang, Y.; Sun, X.; Qian, Z.; Sun, Z.; Liu, Z.; Ren, W.; Han, J.
10.1101/2025.01.15.633288 — neuroscience — Posted on 2025-01-16
2831 SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals
Gen, R.; Addetia, A.; Asarnow, D.; Park, Y.-J.; Quispe, J.; Chan, M. C.; Brown, J. T.; Lee, J.; Campbell, M. G.; Lapointe, C. P.; Veesler, D.
10.1101/2025.01.14.633005 — biochemistry — Posted on 2025-01-15
2833 High-Resolution Structures of Tobacco Mosaic Virus Disks from Cryo-Electron Microscopy
Abu-Baker, I.; Biela, A. P.; Shah, S. N.; Heddle, J. G.; Lomonossoff, G. P.; Blum, A. S.
10.1101/2025.01.15.633274 — biochemistry — Posted on 2025-01-16
2835 Structural mechanism for recognition of E2F1 by the ubiquitin ligase adaptor Cyclin F
Ngoi, P.; Wang, X.; Putta, S.; Da Luz, R. F.; Serrao, V. H. B.; Emanuele, M. J.; Rubin, S. M.
10.1101/2025.01.15.633208 — biochemistry — Posted on 2025-01-16
2836 Reconstructing NOD-like receptor alleles with high internal conservation in Podospora anserina using long-read sequencing
Ament-Velasquez, S. L.; Furneaux, B.; Dheur, S.; Granger-Farbos, A.; Stelkens, R.; Johannesson, H.; Saupe, S. J.
10.1101/2025.01.13.632504 — genomics — Posted on 2025-01-16
2837 From macro to micro: De novo genomes of Aedes mosquitoes enable comparative genomics among close and distant relatives
Morinaga, G.; Balcazar, D.; Badolo, A.; Iyaloo, D.; Mouillaud, T.; Sharakhova, M.; Geib, S. M.; Paupy, C.; Ayala, D.; Powell, J. R.; Gloria-Soria, A.; Soghigian, J.
10.1101/2025.01.13.632753 — genomics — Posted on 2025-01-16
2838 Deciphering the Host-Pathogen Interface in COVID-19: The precision molecular insight into epitranscriptomic modifications of high-impact transcripts
Mazdziarz, M. A.; Krawczyk, K.; Lepiarczyk, E.; Paukszto, L.; Makowczenko, K. G.; Moczulska, B.; Iwanowicz, P.; Kocbach, P.; Sawicki, J.; Gromadzinski, L.; Majewska, M.
10.1101/2025.01.14.632961 — genetics — Posted on 2025-01-15
2839 ER-associated degradation relying on protein O-mannosylation
Lemus, L.; Meyer, H.; Rodriguez, A. I.; Schuldiner, M.; Goder, V.
10.1101/2025.01.15.633243 — cell biology — Posted on 2025-01-15
2840 Harnessing glucocorticoid receptor antagonization to enhance the efficacy of cardiac regenerative growth factors and cytokines
Da Pra, S.; Boriati, S.; Miano, C.; Del Bono, I.; Sacchi, F.; Bongiovanni, C.; Aharonov, A.; Pianca, N.; Tassinari, R.; Ventura, C.; Lauriola, M.; Tzahor, E.; D'Uva, G.
10.1101/2025.01.15.632969 — cell biology — Posted on 2025-01-15
2841 Interaction of Gut-Microbial Amyloids with Endogenous Amyloids can Drives Microglial Hyperactivity and Neuroinflammation in Alzheimers Disease
Javed, I.; Davis, T. P.; Forgham, H.; Albornoz, E. A.; Pietrogrande, G.; Zhu, J.; Chung, K. H. K.; Tahir, M. S.; Ali, S. A.; Qiao, R.; Kakinen, A.; Wolvetang, E. J.; Woodruff, T. M.; Aguado, J.; Otzen, D. E.
10.1101/2025.01.15.633290 — cell biology — Posted on 2025-01-15
2842 Protein phosphatase 4 is required for centrosome asymmetry in fly neural stem cells
Segura, R. C.; Gallaud, E.; von Barnau Sythoff, A.; Aavula, K.; Taylor, J.; Vahdat, D.; Pielage, J.; Cabernard, C.
10.1101/2025.01.15.633270 — cell biology — Posted on 2025-01-15
2844 m3C is a mitochondrial mRNA modification which promotes tumor progression
Penning, A.; Wang, K.; Celerier, M.; Collignon, E.; Primac, I.; Van der Linden, L.; Bizet, M.; Calonne, E.; Hassabi, B.; Hubert, C.; Putmans, P.; Murisier, F.; Larbanoix, L.; Achouri, Y.; Lan, J.; Nemazanyy, I.; Laurent, S.; Jacquemin, P.; Yi, C.; Deplus, R.; Fuks, F.
10.1101/2025.01.15.633161 — cell biology — Posted on 2025-01-16
2847 Trypstatin as a Novel TMPRSS2 Inhibitor with Broad-Spectrum 1 Efficacy Against Corona and Influenza Viruses
Lawrenz, J.; Wettstein, L.; Rodriguez Alfonso, A.; Nchioua, R.; von Maltitz, P.; Albers, D.; Zech, F.; Vandeput, J.; Stevaert, A.; Fois, G.; Preising, N.; Schmierer, E.; Almeida-Hernandez, Y.; Petersen, M.; Staendker, L.; Wiese, S.; Braubach, P.; Frick, M.; Sanchez-Garcia, E.; Sauter, D.; Kirchhoff, F.; Naesens, L.; Muench, J.
10.1101/2025.01.14.632953 — microbiology — Posted on 2025-01-15
2848 Ribosomal protein phylogeography offers quantitative insights into the efficacy of genome-resolved surveys of microbial communities
Schechter, M. S.; Trigodet, F.; Veseli, I. A.; Miller, S. E.; Klein, M. L.; Sever, M.; Maignien, L.; Delmont, T. O.; Light, S. H.; Eren, A. M.
10.1101/2025.01.15.633187 — microbiology — Posted on 2025-01-15
2850 The Paulinella chromatophore transit peptide part2 adopts a structural fold similar to the γ-glutamyl-cyclotransferase fold
Klimenko, V.; Reiners, J.; Applegate, V.; Reimann, K.; Hoeppner, A.; Smits, S. H. J.; Nowack, E. C. M.
10.1101/2025.01.15.633182 — microbiology — Posted on 2025-01-16
2851 Growth in Low Carbon Conditions Reveals Amino-Acid-Coupled Iron Uptake
Lara-Gutierrez, J.; Nguyen, J.; McIlvin, M. R.; Sugiyama, I.; Moran, D. M.; Landry, Z.; Alcolombri, U.; Keegstra, J. M.; Pontrelli, S.; Jimenez-Martinez, J.; Sauer, U.; Hwa, T.; Saito, M.; Stocker, R.
10.1101/2025.01.15.633289 — microbiology — Posted on 2025-01-16
2852 Multi-System Dysregulation in Placental Malaria Contributes to Adverse Perinatal Outcomes in Mice
Ekregbesi, P.; Seibert, B.; Parish, M.; Flores-Garcia, Y.; Creisher, P.; Hoffmann, J.; Liu, J.; Brayton, C.; Zavala, F.; Klein, S.
10.1101/2025.01.15.633265 — microbiology — Posted on 2025-01-16
2856 Dynamics of Bacterial and Viral Transmission in Experimental Microbiota Transplantation
Weagley, J.; Makimaa, H.; Cardenas, L. A. C.; Romani, A.; Sullender, M.; Aggarwal, S.; Hogarty, M.; Rodgers, R.; Kennedy, E.; Foster, L.; Schriefer, L. A.; Baldridge, M. T.
10.1101/2025.01.15.633206 — microbiology — Posted on 2025-01-16
2858 Kremen1 dependence receptor induces SEC24C- and ATG9A-dependent autophagic cell death
Brahim, S.; Schott, T.; Ghasemi Firouzabadi, S.; Negulescu, A.; Geneste, C.; Errazuriz-Cerda, E.; Ichim, G.; Mehlen, P.; Meurette, O.
10.1101/2025.01.15.633131 — cancer biology — Posted on 2025-01-15
2859 Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection
Benito-Martinez, S.; Salavessa, L.; Mace, A.-S.; Lardier, N.; Fraisier, V.; Sires-Campos, J.; Jani, R. A.; Romao, M.; Gayrard, C.; Plessis, M.; Hurbain, I.; Meddour, C. N.; Morel, E.; Boniotto, M.; Manneville, J. B.; Bernerd, F.; Duval, C.; Raposo, G.; Delevoye, C.
10.1101/2025.01.15.632531 — cell biology — Posted on 2025-01-15
2860 Direct binding of arsenicals to nuclear transport factors disrupts nucleocytoplasmic transport
Lorentzon, E.; Lee, J.; Masaryk, J.; Keuenhof, K.; Karlsson, N.; Galipaud, C.; Madsen, R.; Hoog, J. L.; Levin, D. E.; Tamas, M. J.
10.1101/2025.01.13.632748 — cell biology — Posted on 2025-01-15
2861 miR-29a-3p and TGF-beta Axis in Fanconi Anemia: Mechanisms Driving Metabolic Dysfunction and Genome Stability
Bertola, N.; Regis, S.; Cossu, V.; Balbi, M.; Serra, M.; Corsolini, F.; Bottino, C.; Degan, P.; Dufour, C.; Pierri, F.; Cappelli, E.; Ravera, S.
10.1101/2025.01.14.632746 — cell biology — Posted on 2025-01-15
2862 NAMPT activity plays a key role in driving autoimmune processes that characterize type 1 diabetes development in mice
Egbase, D.; Sayers, S.; Haq, N.; Varghese, J.; Bhattacharya, S.; Kynaston, J.; Hubber, E.; Smith, L.; Pullen, T.; Gerdes, H.; Lee, V.; Hopkins, D.; Zhao, M.; Cheah, Y.; Greally, J.; Butterworth, S.; Pearson, J. A.; Bewick, G. A.; Persaud, S.; Caton, P.
10.1101/2025.01.14.632985 — cell biology — Posted on 2025-01-15
2863 Modeling Retinitis Pigmentosa 59: Dhdds T206A and Dhdds K42E knock-in mutant mice are phenotypically similar.
Nguyen, M. N.; Chakraborty, D.; Messinger, J.; Sherry, D. M.; Fliesler, S. J.; Pittler, S. J.
10.1101/2025.01.13.632845 — cell biology — Posted on 2025-01-15
2864 Proximity interactomics identifies RAI14, EPHA2 and PHACTR4 as essential components of Wnt/planar cell polarity pathway in vertebrates
Gomoryova, K.; Zezula, N.; Radaszkiewicz, T.; Paclikova, P.; Cada, S.; Hanakova, K.; Ganji, R. S.; Micka, M.; Potesil, D.; Zdrahal, Z.; Bryja, V.
10.1101/2025.01.15.633117 — cell biology — Posted on 2025-01-15
2866 The central clock drives metabolic rhythms in muscle stem cells
Sica, V.; Smith, J. G.; Deryagin, O.; Andres, E.; Lukesova, V.; Egg, M.; Cabezas-Wallscheid, N.; Benitah, S. A.; Serrano, A. L.; Perdiguero, E.; Munoz-Canoves, P.
10.1101/2025.01.15.633124 — cell biology — Posted on 2025-01-15
2867 Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK Proteins
Lazaro, B.; Tadeo-Masa, F. J.; Rodriguez, A.; Ayuso, L.; Martinez-Lainez, J. M.; Quandt, E.; Bernard, M.; Borghi, F.; Saiardi, A.; Juan-Mateu, J.; Jimenez, J.; Clotet, J.; Bru, S.
10.1101/2025.01.15.633116 — cell biology — Posted on 2025-01-15
2868 An evolutionarily conserved microRNA, miR-185, regulates key pathways that may contribute to implantation failure.
Smith, W.; Edge, J. C.; Tinning, H.; Butt, Z.; Deligianni, F.; Morales, C.; Muter, J.; Brosens, J.; Mascarenhas, M.; Bhandari, H.; O'Connell, M. J.; Lucas, E.; Simpson, N.; Forde, N.
10.1101/2025.01.15.633123 — cell biology — Posted on 2025-01-15
2869 IFT20 regulates lymphatic endothelial cell-cell junctions via endocytic trafficking of VE-cadherin
Paulson, D.; Majumder, A.; Lehmann, Z.; Knutson, L.; Paulson, J.; Lasey, S.; Fink, D. M.
10.1101/2025.01.15.631989 — cell biology — Posted on 2025-01-15
2872 Evaluation of Prostaglandin Receptor Agonists and Eupatilin in the Context of Nephronophthisis
Tata, A.; Rocha, G.; Hureaux, M.; Serafin, A. S.; Poree, E.; Menguy, L.; Goudin, N.; Cagnard, N.; Greau, L.; Fila, M.; Briseno-Roa, L.; Annereau, J.-P.; Saunier, S.; Benmerah, A.
10.1101/2025.01.15.633139 — cell biology — Posted on 2025-01-15
2876 YAP engages RIF1 to dampen replication stress in squamous cell carcinoma.
Bojko, J.; Flynn, B.; Aschenbrenner, B.; Howard, A.; Lay, E.; Krajic, N.; Bailey, E.; Catalan, S.; Gallacher, K.; Sins, E.; Wang, J. A.; Jungwirth, U.; Lichtenberger, B. M.; Walko, G.
10.1101/2024.12.20.629444 — cancer biology — Posted on 2025-01-15
2882 Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants
Toth, B. I.; Bazeli, B.; Janssens, A.; Lisztes, E.; Racsko, M.; Kelemen, B.; Herczeg, M.; Nagy, T. M.; E. Köver, K.; Mitra, A.; Borics, A.; Biro, T.; Voets, T.
10.1101/2024.02.01.578392 — neuroscience — Posted on 2025-01-15
2883 MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases
Woods, V.; Umansky, T.; Russell, S. M.; McGovern, B. L.; Rosales, R.; Rodriguez, M. L.; van Bakel, H.; Sordillo, E. M.; Simon, V.; Garcia-Sastre, A.; White, K. M.; Brubaker, W. F.; Smith, D. M.; Haders, D.
10.1101/2025.01.13.632836 — pharmacology and toxicology — Posted on 2025-01-15
2884 Genome-wide absolute quantification of chromatin looping
Jusuf, J. M.; Grosse-Holz, S.; Gabriele, M.; Mach, P.; Flyamer, I. M.; Zechner, C.; Giorgetti, L.; Mirny, L.; Hansen, A. S.
10.1101/2025.01.13.632736 — biophysics — Posted on 2025-01-15
2887 Regulation of epigenetics and chromosome structure by human ORC2
Su, Z.; Tian, M.; Shibata, E.; Shibata, Y.; Yang, T.; Wang, Z.; Jin, F.; Zang, C.; Dutta, A.
10.1101/2024.12.18.629220 — genomics — Posted on 2025-01-15
2888 Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
Simmons, S. K.; Adiconis, X.; Haywood, N.; Parker, J.; Lin, Z.; Liao, Z.; Tuncali, I.; Al'Khafaji, A.; Shin, A.; Jagadeesh, K.; Gosik, K.; Gatzen, M.; Smith, J. T.; El Kodsi, D. N.; Kuras, Y.; Baecher-Allan, C.; Serrano, G. E.; Beach, T. G.; Garimella, K.; Rozenblatt-Rosen, O.; Regev, A.; Dong, X.; Scherzer, C.; Levin, J. Z.
10.1101/2024.08.13.607784 — genomics — Posted on 2025-01-15
2890 Classifying cell cycle states and a quiescent-like G0 state using single-cell transcriptomics
O'Connor, S. A.; Garcia, L.; Hoover, R. L.; Patel, A. P.; Bartelle, B. B.; Hugnot, J.-P.; PADDISON, P.; Plaisier, C. L.
10.1101/2024.04.16.589816 — cell biology — Posted on 2025-01-15
2892 Organ-Specific Microbiomes of Biomphalaria Snails
Carruthers, L. V.; Nordmeyer, S. C.; Anderson, T. J.; Chevalier, F. D.; Le Clec'h, W.
10.1101/2024.06.11.598555 — microbiology — Posted on 2025-01-15
2893 TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8+ T cells
Lee, H.; Kim, S.-Y.; Kim, S.-H.; Yu, H.; Jeong, S.; Kim, K. H.; Kim, C. G.; Koh, J.-Y.; Kim, H.-D.; Han, J. W.; Park, S.-H.; Eun, H. S.; Shin, E.-C.
10.1101/2025.01.13.632884 — immunology — Posted on 2025-01-15
2894 Using high-dimensional immunophenotyping for mapping immune cell composition in rapid cryopreserved liquid biopsies
Pedersen, J. G.; Jordt, J. C.; Dietz, L. L.; Winther-Larsen, A.; Gammelgaard, K. R.; Jakobsen, M. R.
10.1101/2025.01.13.632307 — immunology — Posted on 2025-01-15
2896 EPSD 2.0: An Updated Database of Protein Phosphorylation Sites across Eukaryotic Species
Chen, M.; Gou, Y.; Lei, M.; Xiao, L.; Zhao, M.; Huang, X.; Liu, D.; Feng, Z.; Peng, D.; Xue, Y.
10.1101/2025.01.13.632887 — bioinformatics — Posted on 2025-01-15
2897 A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the Drosophila Ventral Nerve Cord.
Soffers, J. H.; Beck, E.; Sytkowski, D. J.; Maughan, M. E.; Devasi, D.; Zhu, Y.; Wilson, B.; David Chen, Y.-C.; Erclik, T.; Truman, J.; Skeath, J.; Lacin, H.
10.1101/2024.11.27.625713 — developmental biology — Posted on 2025-01-15
2898 Atlas of the Bacterial Serine-Threonine Kinases expands the functional diversity of the kinome
O'Boyle, B. M.; Yeung, W.; Lu, J. D.; Katiyar, S.; Yaron-Barir, T. M.; Johnson, J. L.; Cantley, L. C.; Kannan, N.
10.1101/2025.01.12.632604 — bioinformatics — Posted on 2025-01-15
2900 A tunable affinity fusion tag for protein self-assembly
Kimbrough, H.; Jensen, J.; Miller, T.; Lange, J. J.; Halfmann, R.
10.1101/2025.01.14.633037 — cell biology — Posted on 2025-01-15
2902 Asparagine endopeptidase promotes radioresistance in breast cancer through ATR pathway modulation
Morillo-Huesca, M.; Tome, M.; Watts, C.; Huertas, P.; Moreno-Bueno, G.; Duran, R. V.; Martinez-Fabregas, J.
10.1101/2025.01.13.632704 — cancer biology — Posted on 2025-01-15
2903 Paclitaxel causes de novo induction of invasive breast cancer cells by repolarizing tumor-associated macrophages
Friedman-DeLuca, M.; Karagiannis, G. S.; Duran, C. L.; Shukla, S.; Li, J.; Condeelis, J. S.; Oktay, M. H.; Entenberg, D.
10.1101/2025.01.13.632767 — cancer biology — Posted on 2025-01-15
2905 CSMA: an ImageJ Plugin for the Analysis of Wound Healing Assays
Pham, T. T.; Sagymbayeva, A.; Elebessov, T.; Onzhanova, Z.; Molnar, F.
10.1101/2025.01.12.632613 — bioinformatics — Posted on 2025-01-15
2906 Fast and accurate modeling of TCR-peptide-MHC complexes using tFold-TCR
Wu, F.; Zhao, Y.; Xiao, Y.; Qin, C.; Wang, F.; Wu, Z.; Huang, L.-K.; Liu, X.; Song, J.; He, B.; Rossjohn, J.; Yao, J.
10.1101/2025.01.12.632367 — bioinformatics — Posted on 2025-01-15
2907 Clustering Digestive Tract Tumors Using Transcriptomic and Mutation Data
Tally, D. G.; Bombina, P.; Reed, J.; Kinne, J.; Abruzzo, L. V.; Coombes, K. R.; Abrams, Z. B.
10.1101/2025.01.13.632722 — bioinformatics — Posted on 2025-01-15
2913 Global extent and change in human modification of terrestrial ecosystems from 1990 to 2022
Theobald, D. M.; Oakleaf, J. R.; Moncrieff, G.; Voigt, M.; Kiesecker, J.; Kennedy, C.
10.1101/2025.01.12.632633 — ecology — Posted on 2025-01-15
2916 Predicting Metabolic Dysfunction Associated Steatotic Liver Disease Risk Using Patient-Derived Induced Pluripotent Stem Cells
Qin, Y.; Chhetri, P.; Theusch, E.; Lim, G.; Teker, S.; Kuang, Y.-L.; Aziziraftar, S. K.; Mehraban, M. H.; Munoz-Howell, A.; Saxena, V.; Le Guillou, D.; Mattis, A. N.; Maher, J. J.; Medina, M. N.
10.1101/2025.01.13.632567 — cell biology — Posted on 2025-01-15
2918 The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
Huhn, A.; Kutuzov, M. A.; Maclean, K.; Uhl, L. F. K.; Mahale, J. M.; Gerard, A.; van der Merwe, P. A.; Dushek, O.
10.1101/2025.01.12.632665 — immunology — Posted on 2025-01-15
2925 Ameliorative Effects of Brideliaferruginea Extracts on Cadmium Chloride-Induced Reproductive Hormone Imbalance, Oxidative Stress, Hepatorenal Damage, Hematological Disorders, and Acute Toxicity in Wistar Rats
Adewuyi, H. A.; Shekari, A.; Adio, S. W.; Oluwatoyin, A. H.; Fagbohun, R. O.; Owoeye, E. A.; Korie, G. C.; Nasiru, M. O.; Olusegun, T. G.-G.; Ishola, A. B.; Gidado, M. O.
10.1101/2025.01.12.632595 — pharmacology and toxicology — Posted on 2025-01-15
2926 Molecular basis of ligand binding and receptor activation at the human A3 adenosine receptor
Zhang, L.; Mobbs, J. I.; Bennetts, F. M.; Venugopal, H.; Nguyen, A. T. N.; Christopoulos, A.; van der Es, D.; Heitman, L. H.; May, L. T.; Glukhova, A.; Thal, D. M.
10.1101/2025.01.12.632629 — pharmacology and toxicology — Posted on 2025-01-15
2927 Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum
Xiu, Q.; Yin, X.; Chen, Y.; Zhang, Z.; Mao, Y.; Wang, T.; Zhang, J.; Zhou, M.; Duan, Y.
10.1101/2025.01.13.632717 — pathology — Posted on 2025-01-15
2928 Mechanisms of dexamethasone-induced bone toxicity in developing bone: a single-cell perspective
Janda, C.; Warmink, K.; Lijnzaad, P.; Vermaat, T. C. W.; Jansen, L.; van Gend, M. C. C.; Zhang, B.; Balwierz, A.; Proost, N.; van de Ven, M.; Merks, J. H. M.; Margaritis, T.
10.1101/2025.01.13.632523 — cancer biology — Posted on 2025-01-15
2929 Enforced E-selectin ligand installation enhances homing and efficacy of adoptively transferred T cells
Hou, Y.; Ye, J.; Qin, K.; Cui, L.-A.; Chung, S.; Chapla, D. G.; Wang, W.; Shi, Y.; Chen, M.; Moremen, K. W.; Sackstein, R.; Wu, P.
10.1101/2025.01.12.632650 — cancer biology — Posted on 2025-01-15
2930 EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing Sarcoma
Hernandez-Munoz, I.; Cuervas, I.; Prada, E.; Pulecio, J.; Gimeno, R.; Andrades, E.; Gomez-Gonzalez, S.; Berenguer-Molins, P.; Acedo-Terrades, A.; Perera-Bel, J.; Bodalo, M.; Nonell, L.; Perez, E.; Grases, D.; Mata, C.; Yelamos, J.; Richaud, Y.; Vidal, E.; Cuartero, Y.; Le Dily, F.; Sunol, M.; Manzanares, A.; Raya, A.; Mora, J.
10.1101/2025.01.13.632712 — cancer biology — Posted on 2025-01-15
2934 2D, or not 2D? Investigating Vertical Signal Integrity of Tissue Slices
Tiesmeyer, S.; Müller-Bötticher, N.; Malt, A.; Long, B.; Marco Salas, S.; Kiessling, P.; Horn, P.; Guillot, A.; Kümmerle, L.; Ma, L.; Tacke, F.; Theis, F. J.; Kuppe, C.; Nilsson, M.; Eils, R.; Ishaque, N.
10.1101/2025.01.13.632601 — bioinformatics — Posted on 2025-01-15
2935 Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex
Villamarin-Ortiz, A.; Reiche, C. F.; Federer, F.; Clark, A. M.; Rolston, J. D.; Soto-Sanchez, C.; Fernandez, E.; Blair, S.; Angelucci, A.
10.1101/2025.01.13.632843 — bioengineering — Posted on 2025-01-15
2937 Initiation of primary T cell--B cell interactions and extrafollicular antibody responses in an organized microphysiological model of the human lymph node
Zatorski, J. M.; Raskovic, D.; Arneja, A.; Kiridena, S.; Ozulumba, T.; Hammel, J. H.; Anbaei, P.; Ortiz-Cardenas, J. E.; Braciale, T. J.; Munson, J.; Luckey, C. J.; Pompano, R. R.
10.1101/2025.01.12.632545 — bioengineering — Posted on 2025-01-15
2938 Stable, Easy-to-Handle, Fully Autologous Electrospun Polymer-Peptide Skin Equivalent for Severe Burn Injuries
Cohen-Gerassi, D.; BenShoshan, M.; Liiani, A.; Reuveni, T.; Loboda, O.; Haratz, M.; Haik, J.; Binderman, I.; Shacham-Diamand, Y.; Sitt, A.; Di Segni, A.; Adler-Abramovich, L.
10.1101/2025.01.12.632550 — bioengineering — Posted on 2025-01-15
2939 Resorbable alginate embolic microsphere for Musculoskeletal embolization applications
Agarwal, S.; Pandey, M.; Duggan, R.; Brien, C. O.; Lewis, A.; Duffy, B.; McCabe, J.; Daly, R.; Farrissey, L.
10.1101/2025.01.13.632707 — bioengineering — Posted on 2025-01-15
2942 Precision cutaneous stimulation in freely moving mice
Parkes, I.; Schorscher-Petcu, A.; Gan, Q.; Browne, L. E.
10.1101/2024.08.06.606618 — neuroscience — Posted on 2025-01-15
2944 Modification of Non-photochemical Quenching Pathways in the C4 Model Plant Setaria viridis Revealed Shared and Unique Photoprotection Mechanisms as Compared to C3 Plants
Milburn, G.; Morris, C. M.; Kosola, E.; Patel-Tupper, D.; Liu, J.; Pham, D. H.; Acosta-Gamboa, L.; Stone, W. D.; Pardi, S.; Hillman, K.; McHargue, W. E.; Becker, E.; Kang, X.; Sumner, J.; Bailey, C.; Thielen, P. M.; Jander, G.; Kane, C. N.; McAdam, S. A. M.; Lawton, T. J.; Nusinow, D. A.; Zhang, F.; Gore, M. A.; Cheng, J.; Niyogi, K. K.; Zhang, R.
10.1101/2025.01.12.632622 — plant biology — Posted on 2025-01-15
2945 FaRIF at the Core of Strawberry Fruit Ripening: Deciphering its Targets and Interaction Networks
Martin-Pizarro, C.; Franco-Zorrilla, J. M.; Perotti, M. F.; Lozano-Duran, R.; Qin, G.; Pose, D.
10.1101/2025.01.13.631932 — plant biology — Posted on 2025-01-15
2948 The Arabidopsis dehydrin ERD14 chaperones the BRL3 receptor to confer drought resistance
Cano-Delgado, A. I.; Marques-Bueno, M.; Herrero-Garcia, I.; Pistillo, S.; Gupta, A.; Lozano-Elena, F.; Blasco-Escamez, D.; Karampelias, M.; Fabregas, N.; Strotmann, V. I.; Stahl, Y.
10.1101/2025.01.15.633155 — plant biology — Posted on 2025-01-15
2951 Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive behavior
Ruyle, B.; Masud, S.; Kesaraju, R.; Tahirkheli, M.; Modh, J.; Roth, C. G.; Lopera, S. A.; Lintz, T.; Higginbotham, J. A.; Massaly, N.; Moron, J. A.
10.1101/2024.09.16.613257 — physiology — Posted on 2025-01-15
2952 Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology
Ahn, S. H.; Halgren, K.; Grzesiak, G.; MacRenaris, K. W.; Sue, A.; Xie, H.; Demireva, E.; O'Halloran, T. V.; Petroff, M. G.
10.1101/2025.01.11.632558 — pathology — Posted on 2025-01-15
2955 TimberTracer: A Comprehensive Framework for the Evaluation of Carbon Sequestration by Forest Management and Substitution of Harvested Wood Products.
Boukhris, I.; Collalti, A.; Lahssini, S.; Dalmonech, D.; Nakhle, F.; Testolin, R.; Chiricao, M. V.; Santini, M.; Valentini, R.
10.1101/2024.01.24.576985 — ecology — Posted on 2025-01-15
2956 Unintended bias in the pursuit of collinearity solutions in fMRI analysis
Mumford, J. A.; Demidenko, M. I.; Bjork, J. M.; Garavan, H. P.; Hagler, D. J.; Nelson, S. M.; Wager, T. D.; Poldrack, R. A.
10.1101/2025.01.14.633053 — neuroscience — Posted on 2025-01-15
2958 Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity
Pytys, A.; Ijaz, R.; Buszka, A.; Milek, J.; Figiel, I.; Wardaszka, P.; Roszkowska, M.; Mierzwa, N.; Wojtas, A.; Kerstein, E.; Serwa, R.; Kalita, K.; Dzakpasu, R.; Dziembowska, M.; Wlodarczyk, J.; Wojtowicz, T.
10.1101/2025.01.15.633145 — neuroscience — Posted on 2025-01-15
2959 Neurite density but not myelination of specific fiber tracts links polygenic scores to general intelligence
Stammen, C.; Schneider Penate, J.; Metzen, D.; Hoenscher, M. J.; Fraenz, C.; Schlueter, C.; Guentuerkuen, O.; Kumsta, R.; Genc, E.
10.1101/2025.01.15.633108 — neuroscience — Posted on 2025-01-15
2961 Distinct modes of dopamine modulation on striatopallidal synaptic transmission
Lee, Y.; Reva, M.; Kim, K. J.; Kim, Y.; Cho, E.; Kim, H.-j.; Jeong, M.; Myung, K.; Li, Y.; Lee, S. E.; Kim, E.; Lee, C. J. J.; Luscher, C.; Kim, J.-I.
10.1101/2025.01.15.633147 — neuroscience — Posted on 2025-01-15
2962 Different artificial light modalities during daytime have all positive effects on attention and alertness
Bjerrum, L. B.; Visted, E.; Nordhus, I. H.; Osnes, B.; Bjorvatn, B.; Bugge Kambestad, O.; Hansen, M. E.; Sorensen, L.; Flo-Groeneboom, E.
10.1101/2025.01.15.633100 — neuroscience — Posted on 2025-01-15
2965 An MRI-informed histo-molecular analysis implicates ependymal cells in the pathogenesis of periventricular pathology in multiple sclerosis
Groh, A. M.; Afanasiev, E.; Thevakumaran, R.; Callahan-Martin, L.; Creeggan, F.; Yaqubi, M.; Zandee, S.; Prat, A.; Rudko, D. A.; Stratton, J. A.
10.1101/2025.01.14.633055 — neuroscience — Posted on 2025-01-15
2969 ERGA-BGE Reference Genome of Phyllidia flava (Nudibranchia: Phyllidiidae), a Relict Species Endemic to the Mediterranean Sea
Galia-Camps, C.; Pontes, M.; Marcussen, T.; Struck, T. H.; Oomen, R.; Böhne, A.; Monteiro, R.; Aguilera, L.; Gut, M.; Ferreira, F. C.; Cruz, F.; Gomez-Garrido, J.; Alioto, T. S.; De Panis, D.
10.1101/2025.01.14.632929 — genomics — Posted on 2025-01-15
2971 Characterising the periodontal granulation tissue using scRNAseq.
Neves, V. C. M.; Zhu, W.; Fung, K.; Dhami, P.; Sharpe, P.; Krivanek, J.; Nibali, L.; Zhang, C.
10.1101/2025.01.13.632112 — cell biology — Posted on 2025-01-15
2972 Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer's disease
Castanho, I.; Yeganeh, P. N.; Boix, C. A.; Morgan, S. L.; Mathys, H.; Prokopenko, D.; White, B.; Soto, L. M.; Pegoraro, G.; Shah, S.; Ploumakis, A.; Kalavros, N.; Bennett, D. A.; Lange, C.; Kim, D. Y.; Bertram, L.; Tsai, L.-H.; Kellis, M.; Tanzi, R. E.; Hide, W.
10.1101/2025.01.13.632801 — neuroscience — Posted on 2025-01-15
2973 Small or absent Visual Word Form Area is a trait of dyslexia
Mitchell, J. L.; Yablonski, M.; Stone, H. L.; Fuentes-Jimenez, M.; Takada, M.; Tang, K. A.; Tran, J. E.; Chou, C.; Yeatman, J. D.
10.1101/2025.01.14.632854 — neuroscience — Posted on 2025-01-15
2974 Real-time fMRI neurofeedback modulates auditory cortex activity and connectivity in schizophrenia patients with auditory hallucinations: A controlled study
Bauer, C. C. C.; Zhang, J.; Morfini, F.; Hinds, O.; Wighton, P.; Lee, Y.; Stone, L.; Awad, A.; Okano, K.; Hwang, M.; Hammoud, J.; Nestor, P.; Whitfield-Gabrieli, S.; Shinn, A. K.; Niznikiewicz, M. A.
10.1101/2025.01.13.632809 — neuroscience — Posted on 2025-01-15
2975 It takes two: Aberrant repair and low-grade inflammation characterizes bronchiolitis obliterans syndrome after lung transplantation in serum proteomic analysis
Van der Ploeg, E.; Faiz, A.; Teitsma, G.; Brotons, A. S.; Govorukhina, N.; Sand, J.; Leeming, D.; Melgert, B. N.; Horvatovich, P.; Burgess, J. K.; Gan, C. T.
10.1101/2025.01.13.632807 — bioinformatics — Posted on 2025-01-15
2977 SAMson: an automated brain extraction tool for rodents using SAM
Soler, D. P.; Selim, M. K.; Martinez-Tazo, P.; Munoz-Moreno, E.; Ramos-Cabrer, P.; Lopez-Larrubia, P.; De Santis, S.; Canals, S.; Pertusa, A.
10.1101/2024.03.07.583982 — neuroscience — Posted on 2025-01-15
2979 Variation in albumin glycation rates in birds suggests resistance to relative hyperglycaemia rather than conformity to the pace of life syndrome hypothesis
Moreno Borrallo, A.; Jaramillo Ortiz, S.; Schaeffer-Reiss, C.; Quintard, B.; Rey, B.; Bize, P.; Viblanc, V. A.; Boulinier, T.; Chastel, O.; S. Gutierrez, J.; Masero, J. A.; Bertile, F.; Criscuolo, F.
10.1101/2024.07.02.600014 — evolutionary biology — Posted on 2025-01-15
2980 3D Imaging with Superior Resolution Using Atacama Clear
Lacko, L.; Choi, T.; de Silva, N.; Liu, Y.; Jamies, E. A.; Evans, T.; Hurtado, R.
10.1101/2024.01.22.576689 — molecular biology — Posted on 2025-01-15
2983 Reprogramming genetic circuits using space
Alejaldre, L.; Miro-Bueno, J.; Hueso-Gil, A.; Grozinger, L.; Tas, H.; Geibler, S.; Goni-Moreno, A.
10.1101/2024.03.20.585869 — synthetic biology — Posted on 2025-01-15
2984 Single-cell transcriptomics-guided development of flow cytometric tests predicting chronic myeloid leukemia blast crisis transformation at chronic phase diagnosis
Yu, M.; Krishnan, V.; Shyamsunder, P.; Lee, K. L.; Schmidt, F.; Ren, X.; Chuah, C.; Prabhakar, S.; Saunders, V.; Yeung, D.; Shanmuganathan, N.; Yong, A.; Hughes, T.; Ong, S. T.
10.1101/2025.01.09.632094 — cancer biology — Posted on 2025-01-15
2988 Deletion of the moe A gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism
Escobar Doncel, A.; Patinios, C.; Campos, A.; Walter Costa, M. B.; Turkina, M. V.; Murace, M.; Staals, R. H. J.; Vignolini, S.; Dutilh, B. E.; Ingham, C.
10.1101/2025.01.13.632688 — microbiology — Posted on 2025-01-15
2990 Engineered biological neural networks as basic logic operators
Küchler, J.; Vulic, K.; Yao, H.; Valmaggia, C.; Ihle, S. J.; Weaver, S.; Vörös, J.
10.1101/2024.12.23.630065 — neuroscience — Posted on 2025-01-15
2991 Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology
Ahn, S. H.; Halgren, K.; Grzesiak, G.; MacRenaris, K. W.; Sue, A.; Xie, H.; Demireva, E.; O'Halloran, T. V.; Petroff, M. G.
10.1101/2025.01.11.632558 — pathology — Posted on 2025-01-15
2992 A novel tool for designing targeted gene amplicons and an optimised set of primers for high-throughput sequencing in tuberculosis genomic studies
Wang, L.; Thawong, N.; Thorpe, J.; Higgins, M.; Tan, M. K. I.; Sawaengdee, W.; Mahasirimongkol, S.; Perdigao, J.; Campino, S.; Clark, T. G.; Phelan, J. E.
10.1101/2025.01.13.632698 — bioinformatics — Posted on 2025-01-15
2993 A Cross-Species Atlas of the Dorsal Vagal Complex Reveals Neural Mediators of Cagrilintide's Effects on Energy Balance
Ludwig, M. Q.; Coester, B.; Gordian, D.; Hassan, S.; Tomlinson, A. J.; Toure, M. H.; Christensen, O. P.; Moltke-Prehn, A.; Brown, J. M.; Rausch, D. M.; Gowda, A.; Wu, I.; Kernodle, S.; Dong, V.; Ayensu-Mensah, M.; Sabatini, P. V.; Shin, J. H.; Kirigiti, M.; Egerod, K. L.; Le Foll, C.; Lundh, S.; Gerstenberg, M. K.; Lutz, T. A.; Kievit, P.; Secher, A.; Raun, K.; Myers, M. G.; Pers, T. H.
10.1101/2025.01.13.632726 — bioinformatics — Posted on 2025-01-15
2995 Q-score as a reliability measure for protein, nucleic acid, and small molecule atomic coordinate models derived from 3DEM density maps
Pintilie, G.; Shao, C.; Wang, Z.; Hudson, B. P.; Flatt, J. W.; Schmid, M. F.; Morris, K. L.; Burley, S. K.; Chiu, W.
10.1101/2025.01.14.633006 — biochemistry — Posted on 2025-01-15
2996 Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
Sitron, C. S.; Trinkaus, V. A.; Galesic, A.; Garhammer, M.; Yuste Checa, P.; Dransfeld, U.; Feigenbutz, D.; Zhang, J.; Dudanova, I.; Harper, J. W.; Hartl, F. U.
10.1101/2025.01.13.632710 — biochemistry — Posted on 2025-01-15
2997 UniversalEPI: a generalized attention-based deep ensemble model to accurately predict enhancer-promoter interactions across diverse cell types and conditions
Grover, A.; Zhang, L.; Muser, T.; Häfliger, S.; Wang, M.; Yates, J.; Van Allen, E.; Theis, F. J.; Ibarra, I. L.; Krymova, E.; Boeva, V.
10.1101/2024.11.22.624813 — genomics — Posted on 2025-01-15
2998 Developmentally cascading structures do not lose evolutionary potential, but compound developmental instability in rat molars
Vitek, N. S.; Saks, E.; Dong, A.; Burroughs, R.; Ward, D. L.; Pomeroy, E.; Martin-Gronert, M.; Ozanne, S. E.
10.1101/2025.01.13.632740 — evolutionary biology — Posted on 2025-01-15
3000 Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration
Schwayer, C.; Barbiero, S.; Brückner, D. B.; Baader, C.; Repina, N. A.; Diaz, O. E.; Meylan, L. C.; Kalck, V.; Suppinger, S.; Yang, Q.; Schnabl, J.; Kilik, U.; Camp, J. G.; Stockinger, B.; Bühler, M.; Stadler, M. B.; Hannezo, E.; Liberali, P.
10.1101/2025.01.14.632683 — cell biology — Posted on 2025-01-15
3001 Condensate screening identifies YM155 as β-catenin condensate inhibitor in colorectal cancer
Manzato, C.; Sirati, N.; Knol, B. A.; Kuiken, H. J.; Morris, B.; Fleming, C.; Beijersbergen, R. L.; Schuijers, J.
10.1101/2025.01.13.632724 — molecular biology — Posted on 2025-01-15
3009 A fast numerical integration scheme for clonal expansion processes on graphs
Paterson, C. G. B.; Gao, M.; Hellier, J.; Luebeck, G.; Wedge, D. C.; Bozic, I.
10.1101/2025.01.13.632690 — cancer biology — Posted on 2025-01-15
3010 Double-stranded RNA responses, neoantigen presentation and suppression of hepatocellular carcinoma through NMD inhibition via endonuclease SMG6
Arpa, E. S.; Ricci, V.; Shapiro, I. E.; Jokic, M.; Gonzalez Menendez, I.; Quintanilla-Fend, L.; Benechet, A. P.; Rehwinkel, J.; Luther, S. A.; Bassani-Sternberg, M.; Gatfield, D.
10.1101/2025.01.13.632668 — cancer biology — Posted on 2025-01-15
3012 Recombinant production in Escherichia coli of functionally active alpha-hemolysin from the human pathogen Staphylococcus aureus
Diaz-Varela, J. L.; Sabia, V.; Heras-Marquez, D.; Laxalde-Fernandez, D.; Martinez-del-Pozo, A.; Garcia-Linares, S.
10.1101/2025.01.14.632992 — biochemistry — Posted on 2025-01-15
3013 Monitoring monomer-specific acyl-tRNA levels in cells with PARTI
Pressimone, M. A.; Schissel, C. K.; Goss, I. H.; Swenson, C. V.; Schepartz, A.
10.1101/2025.01.14.633079 — biochemistry — Posted on 2025-01-15
3017 Extensive length and homology dependent chimerism in pool-packaged AAV libraries
Lalanne, J.-B.; Mich, J. K.; Huynh, C.; Hunker, A.; McDiarmid, T. A.; Levi, B. P.; Ting, J. T.; Shendure, J.
10.1101/2025.01.14.632594 — genomics — Posted on 2025-01-15
3020 Genetic background sets the trajectory of cancer evolution
Aitken, S. J.; Connor, F.; Feig, C.; Rayner, T. F.; Lukk, M.; Luft, J.; Aitken, S.; Arnedo-Pac, C.; Hayes, J. F.; Nicholson, M. D.; Sundaram, V.; Verburg, J. C.; Connelly, J.; Anderson, C. J.; Behm, M.; Campbell, S.; Daunesse, M.; Ewing, A.; Kaiser, V. B.; Kentepozidou, E.; Pich, O.; Redmond, A. M.; Santoyo-Lopez, J.; Sentis, I.; Talmane, L.; Liver Cancer Evolution Consortium, ; Flicek, P.; Lopez-Bigas, N.; Semple, C. A.; Taylor, M. S.; Odom, D. T.
10.1101/2025.01.13.632787 — genomics — Posted on 2025-01-15
3021 ERGA-BGE genome of Stigmatoteuthis arcturi Robson, 1948: the jewelled squid
Fernandez-Alvarez, F. A.; Bernal-Bajo, A.; Escudero, N.; Conejero, M.; Riesgo, A.; Fernandez, R.; Monteiro, R.; Bohne, A.; Aguilera, L.; Gut, M.; Alioto, T. S.; Ferreira, F. C.; Cruz, F.; Gomez-Garrido, J.; Brown, T.
10.1101/2025.01.13.632676 — genomics — Posted on 2025-01-15
3022 A simple demonstration of a privacy-preserving de-centralised genotype imputation workflow
Letaillandier, A.; Picard-Druet, D.; Ludwig, T. E.; Marenne, G.; Herzig, A. F.
10.1101/2025.01.13.632689 — genetics — Posted on 2025-01-15
3023 Whole-genome duplication increases genetic diversity and load in outcrossing Arabidopsis
Vlcek, J.; Hamala, T.; Cobo, C. V.; Curran, E.; Sramkova, G.; Slotte, T.; Schmickl, R.; Yant, L.; Kolar, F.
10.1101/2025.01.12.632621 — evolutionary biology — Posted on 2025-01-15
3025 Evolution of Wolbachia male-killing mechanism within a host species
Arai, H.; Wijonarko, A.; Katsuma, S.; Naka, H.; Kageyama, D.; Hornett, E. A.; Hurst, G. D. D.
10.1101/2025.01.13.632718 — evolutionary biology — Posted on 2025-01-15
3028 A general framework for cycles in ecology
Moura, R. O.; Calleja Solanas, V.; LANGA, J. A.; Godoy, O.
10.1101/2025.01.13.632680 — ecology — Posted on 2025-01-15
3029 Reactivation of developmentally silenced globin genes through genomic deletions reveals that enhancer distance matters
Felder, A.-K.; Tjalsma, S. J. D.; Verhagen, H. J. M. P.; Majied, R.; Versteger, M. J. A. M.; Verheul, T. C. J.; Mohnani, R.; Gremmen, R.; Krijger, P. H. L.; Philipsen, S.; van den Akker, E.; de Laat, W.
10.1101/2025.01.13.632719 — molecular biology — Posted on 2025-01-15
3030 Quorum sensing mediates morphology and motility transitions in the model archaeon Haloferax volcanii
Chatterjee, P.; Consoli, C. E.; Schiller, H.; Winter, K. K.; McCallum, M. E.; Schulze, S.; Pohlschroder, M.
10.1101/2025.01.14.633064 — microbiology — Posted on 2025-01-15
3034 Antibacterial, antibiofilm and anti-quorum sensing activities of 1,2,3,5-tetrazine derivatives linked to a benzothiazole moiety
Dzoyem, J. P.; Tsemeugne, J.; Pone Kamdem, B.; Foyou Meupiap, R.; Kuate, B. A.; Mkounga, P.; Fekam Boyom, F.; McGaw, L. J.
10.1101/2025.01.14.632941 — microbiology — Posted on 2025-01-15
3037 Pseudomonas superinfection drives Pf phage transmission within airway infections in patients with cystic fibrosis
Pourtois, J. D.; Haddock, N. L.; Gupta, A.; Khosravi, A.; Martinez, H.; Schmidt, A. K.; Prakash, P. S.; Jain, R.; Fleming, P.; Chang, T. H.; Milla, C.; Secor, P. R.; De Leo, G. A.; Bollyky, P. L.; Burgener, E. B.
10.1101/2025.01.14.632786 — microbiology — Posted on 2025-01-15
3039 Microbiota assembly of specific pathogen-free neonatal mice
Kennedy, E.; Weagley, J.; Kim, A.; Antia, A.; DeVeaux, A.; Baldridge, M.
10.1101/2025.01.14.633035 — microbiology — Posted on 2025-01-15
3041 Combinatorial phenotypic landscape enables bacterial resistance to phage infection
Gupta, A.; Morella, N.; Sutormin, D.; Li, N.; Gaisser, K.; Robertson, A.; Ispolatov, Y.; Seelig, G.; Dey, N.; Kuchina, A.
10.1101/2025.01.13.632860 — systems biology — Posted on 2025-01-15
3043 MyVivarium: A cloud-based lab animal colony management application with realtime ambient sensing
Vidva, R.; Raza, M. A.; Prabhakaran, J.; Sheikh, A.; Sharp, A.; Ott, H.; Moore, A.; Fleisher, C.; Netherton, H.; Goldstein, E.; Pitychoutis, P. M.; Nguyen, T. V.; Sathyanesan, A.
10.1101/2024.08.10.607395 — bioinformatics — Posted on 2025-01-14
3044 APE1 active site residue Asn174 stabilizes the AP-site and is essential for catalysis
DeHart, K. M.; Hoitsma, N. M.; Thompson, S. H.; Borin, V. A.; Agarwal, P. K.; Freudenthal, B. D.
10.1101/2025.01.14.633034 — biochemistry — Posted on 2025-01-15
3045 DNA replication in primary hepatocytes without the six-subunit ORC
Przanowska, R. K.; Chen, Y.; Uchida, T. O.; Shibata, E.; Hao, X.; Rueda, I. S.; Jensen, K.; Przanowski, P.; Trimboli, A.; Shibata, Y.; Leone, G.; Dutta, A.
10.1101/2024.04.04.588006 — genetics — Posted on 2025-01-14
3049 Enhancing tumor-infiltrating T cells with an exclusive fuel source
Miller, M. L.; Thauland, T. J.; Nagarajan, R.; Zuo, W. E.; Moreno Lastre, M. A.; Butte, M. J.
10.1101/2024.05.20.595053 — immunology — Posted on 2025-01-14
3054 Spatiotemporal Complexity in the Psychotic Brain
Li, Q.; Liu, J.; Pearlson, G. D.; Chen, J.; Wang, Y.-P.; Turner, J. A.; Calhoun, V. D.
10.1101/2025.01.14.632764 — neuroscience — Posted on 2025-01-14
3058 Affiliative behaviours regulate allostasis development and shape biobehavioural trajectories in horse
Valenchon, M.; Reigner, F.; Lefort, G.; Adriaensen, H.; Gesbert, A.; Barriere, P.; Gaude, Y.; Elleboudt, F.; Levy, I.; Ducluzeau, C.; Dupont, J.; Laine, A.-L.; Uszynski, I.; Dardente, H.; Poupon, C.; Lansade, L.; Calandreau, L.; Keller, M.; Barriere, D. A.
10.1101/2025.01.14.632964 — neuroscience — Posted on 2025-01-14
3060 Arrow heads at Obi-Rakhmat (Uzbekistan) 80 ka ago
Plisson, H.; Kharevich, A.; Kharevich, V.; Chistyakov, P.; Zotkina, L.; Baumann, M.; Pubert, E.; Kolobova, K.; Krivoshapkin, A.
10.1101/2025.01.14.632810 — paleontology — Posted on 2025-01-14
3061 Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis
Sun, B.; Fernandes, D.; Soltys, J.; Kathrin-Kienzler, A.; Paneva, S.; Harrison, R.; Ramanathan, S.; Harrison, A.; Makuch, M.; Fichtner, M.; Donat, R.; Akdeniz, D.; Bayuangga, H.; Im, M. G.; Williams, R.; Vasconcelos, A.; Thompson, S.; Fower, A.; Sun, R.; Fox, H.; Mgbachi, V.; Davies, A.; Tseng, M.; Handel, A.; Kelly, M.; Zhao, M.; Bancroft, J.; Bashford-Rogers, R.; Pluvinage, J.; Dandekar, R.; Alvarenga, B.; Dustin, L.; Rinaldi, S.; Owens, R.; Anthony, D.; Bennett, D.; Waters, P.; Davis, S.; Wilson, M.; O'Connor, K.; Carvalho, A. L.; Irani, S.
10.1101/2025.01.14.631703 — immunology — Posted on 2025-01-14
3062 Weak and tunable adhesion-clutch drives rapid cell migration and glioblastoma motility
Baba, K.; Fukushi-Kumagaya, A.; Morisaki, M.; Takeuchi, R.; Xiao, Z.; Nagashima, Y.; Sakai, M.; Higashiguchi, Y.; Katsuno-Kambe, H.; Katsuma, A.; Ueda, Y.; Kamioka, Y.; Daisuke, K.; Kinashi, T.; Kanemura, Y.; Inagaki, N.
10.1101/2025.01.13.632873 — cell biology — Posted on 2025-01-14
3063 Programmed ribosomal frameshifting during PLEKHM2 mRNA decoding generates a constitutively active mediator of kinesin-1-dependent lysosome transport
Loughran, G.; De Pace, R.; Ding, N.; Zhang, J.; Jungreis, I.; Carancini, G.; Mudge, J. M.; Wang, J.; Kellis, M.; Atkins, J. F.; Baranov, P.; Firth, A.; Li, X.; Bonifacino, J.; Khan, Y. A.
10.1101/2024.08.30.610563 — molecular biology — Posted on 2025-01-14
3067 ECM Signatures Reveal Quiescent Stem Cell Diversity in the Colonic Niche
Hickey, S. E.; Andreatta, M.; Enright, C.; Boucrot, E.; Kiely, P.; Cashman, S.; Carmona, S. J.; McGourty, K.
10.1101/2025.01.13.632868 — developmental biology — Posted on 2025-01-14
3068 The thin descending limb of the loop of Henle originates from proximal tubule cells during mouse kidney development
Chung, E.; Nosrati, F.; Adam, M.; Potter, A.; Sayed, M.; Humphreys, B.; Lim, H.-W.; Hu, Y.-C.; Potter, S. S.; Park, J.-S.
10.1101/2025.01.14.633065 — developmental biology — Posted on 2025-01-14
3071 Tissue-dependent mechanosensing by cells derived from human tumors
Parihar, K.; Nukpezah, J.; Iwamoto, D.; Cruz, K.; Byfield, F.; Chin, L.; Murray, M.; Mendez, M.; van Oosten, A. S.; Herrmann, A.; Charrier, E. E.; Galie, P. A.; Donlick, M.; Lee, T.; Janmey, P. A.; Radhakrishnan, R.
10.1101/2025.01.11.632563 — biophysics — Posted on 2025-01-14
3073 Soil Carbon Sequestration in Nothofagus obliqua Forests with Different Canopy Cover Levels under Silvopastoral Management
Ramos, C.; Zagal, E.; Timmusk, S.; Dube, F.; Paulino, L.; Ortiz, J.; Intriago, J.; Fuentes, J. P.
10.1101/2025.01.11.632554 — ecology — Posted on 2025-01-14
3074 Keystone engineering enables collective range expansion in microbial communities
Simsek, E.; Villalobos, C. A.; Sahu, K.; Zhou, Z.; Luo, N.; Lee, D.; Ma, H. R.; Anderson, D. J.; Lee, C. T.; You, L.
10.1101/2025.01.11.632568 — ecology — Posted on 2025-01-14
3075 Self-Organizing Assembloids Reveal Enteric Nervous System Dynamics in Gut Homeostasis and Regeneration
Sari, I.; Uzun, B.; Oguz, M. O.; Gursoy, E.; Satlykov, N.; Gemalmayan, D. A.; Gonullu, N.; Valenta, T.; Aerts Kaya, F.; Gizer, M.; Korkusuz, P.; Degirmenci, B.
10.1101/2025.01.14.632538 — developmental biology — Posted on 2025-01-14
3077 Zonal endothelial cell heterogeneity underlies murine renal vascular development.
Luo, P. M.; Ahuja, N.; Chaney, C.; Pi, D.; Cwiek, A.; Markowska, Z.; Hiremath, C.; Marciano, D. K.; Hirschi, K. K.; Iruela-Arispe, M. L.; Carroll, T. J.; Cleaver, O.
10.1101/2025.01.13.632837 — developmental biology — Posted on 2025-01-14
3079 Conservation of symmetry breaking at the level of chromatin accessibility between fly species with unrelated anterior determinants
Amiri, E. E.; Tenger-Trolander, A.; Li, M.; Julian, A. T.; Kasan, K.; Sanders, S. A.; Blythe, S. A.; Schmidt-Ott, U.
10.1101/2025.01.13.632851 — developmental biology — Posted on 2025-01-14
3080 High resolution multi-scale profiling of embryonic germ cell-like cells derivation reveals pluripotent state transitions in humans
Stucchi, S.; Sepulveda-Rincon, L. P.; Dion, C.; Matassa, G.; Valenti, A.; Cheroni, C.; Vitriolo, A.; Prazzoli, F.; Young, G.; Rigoli, M. T.; Ciprietti, M.; Muda, B.; Heckhausen, Z.; Hajkova, P.; Caporale, N.; Testa, G.; Leitch, H. G.
10.1101/2025.01.14.632914 — developmental biology — Posted on 2025-01-14
3081 Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury
Marchand, T.; Akinnola, K. E.; Takeishi, S.; Maryanovich, M.; Pinho, S.; Saint-Vanne, J.; Birbrair, A.; Lamy, T.; Tarte, K.; Frenette, P.; Gritsman, K.
10.1101/2023.01.12.523842 — cell biology — Posted on 2025-01-14
3082 Joint single-cell measurements of surface proteins, intracellular proteins and gene expression with icCITE-seq
Chen, K. Y.; Takeshima, Y.; Zorzetto-Fernandes, A. L.; Makino, K.; Kibayashi, T.; Hata, M.; Ichiyama, K.; Croteau, J.; Taylor, K.; Sakaguchi, S.
10.1101/2025.01.11.632564 — immunology — Posted on 2025-01-14
3083 Diacylglycerol kinase zeta dictates CD40-mediated immune synapse formation, mTORC1 signaling and plasma cell fate in B lymphocytes
Fernandez-Barrecheguren, A.; Fernandez-Rego, A.; Fuentes-Cantos, L.; Pons, T.; Estrada, B. S.; Iborra-Pernichi, M.; Ebrahimi, T.; Sagrera-Aparisi, A.; Cogliati, S.; Martinez-Martin, N.; Jimenez-Saiz, R.; Carrasco, Y. R.
10.1101/2025.01.11.632541 — immunology — Posted on 2025-01-14
3085 Non-canonical activation of PAR1 induces autophagy in mammalian breast cancer cells
Saha, S.; KUMAR, R.; SARANGI, S.; TAPADER, R.; RAY, T.; GOPE, A.; NAG, N.; PAL, A.; PAL, A.
10.1101/2025.01.11.632575 — cancer biology — Posted on 2025-01-14
3086 Simultaneous Targeting of KRAS and CDK4 Synergistically Suppresses Pancreatic Cancer Cells
Paulsohn, M.-B.; Frahnert, K. H.; Fang, X.; Schneider, C.; Tapia Contreras, C.; Schneider, G.; Hessmann, E.; Dobbelstein, M.
10.1101/2025.01.11.632518 — cancer biology — Posted on 2025-01-14
3093 Extreme high-diversity barcoded HIV library enables single cell multi-omics analysis of viral expression and fate determination
Zhang, T.-h.; Sheng, L.; Meng, X.; Lai, W.; Du, Y.; Shi, Y.; Wen, J.; Kamata, M.; Chanda, S. K.; Chen, I. S.; Sun, R.
10.1101/2025.01.14.632503 — microbiology — Posted on 2025-01-14
3095 Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis
Sun, B.; Fernandes, D.; Soltys, J.; Kathrin-Kienzler, A.; Paneva, S.; Harrison, R.; Ramanathan, S.; Harrison, A.; Makuch, M.; Fichtner, M.; Donat, R.; Akdeniz, D.; Bayuangga, H.; Im, M. G.; Williams, R.; Vasconcelos, A.; Thompson, S.; Fower, A.; Sun, R.; Fox, H.; Mgbachi, V.; Davies, A.; Tseng, M.; Handel, A.; Kelly, M.; Zhao, M.; Bancroft, J.; Bashford-Rogers, R.; Pluvinage, J.; Dandekar, R.; Alvarenga, B.; Dustin, L.; Rinaldi, S.; Owens, R.; Anthony, D.; Bennett, D.; Waters, P.; Davis, S.; Wilson, M.; O'Connor, K.; Carvalho, A. L.; Irani, S.
10.1101/2025.01.14.631703 — immunology — Posted on 2025-01-14
3097 Bacterial vaginosis-driven changes in cervicovaginal immunity that expand the immunological hypothesis for increased HIV susceptibility
MacLean, F.; Tsegaye, A. T.; Graham, J. B.; Swarts, J. L.; Vick, S. C.; Potchen, N.; Cruz Talavera, I.; Warrier, L.; Dubrulle, J.; Schroeder, L. K.; Saito, A.; Thomas, K. K.; Mack, M.; Sabo, M. C.; Chohan, B. H.; Ngure, K.; Mugo, N.; Lingappa, J. R.; Lund, J. M.
10.1101/2024.07.03.601916 — immunology — Posted on 2025-01-14
3098 Data-driven synapse classification reveals a logic of glutamate receptor diversity
Micheva, K. D.; Simhal, A. K.; Schardt, J.; Smith, S. J.; Weinberg, R. J.; Owen, S. F.
10.1101/2024.12.11.628056 — neuroscience — Posted on 2025-01-14
3101 OVEREXPRESSION OF TEMPRANILLO-LIKE PROTEINS PROMOTES ENDORMANCY RELEASE IN POPLAR
Gomez-Soto, D.; Triozzi, P. M.; Conde, D.; del Barrio, C.; Allona, I.; Perales, M.
10.1101/2025.01.11.632540 — plant biology — Posted on 2025-01-14
3102 Skeletal muscle mitochondria contain nuclear-encoded RNA species prior to and following adaptation to exercise training in rats
Silver, J. L.; Lamon, S.; Loke, S.; Mazzarino, G.; Croft, L.; Ziemann, M.; Wadley, G. D.; Trewin, A. J.
10.1101/2025.01.12.631800 — physiology — Posted on 2025-01-14
3103 An online GPCR drug discovery resource
Caroli, J.; Andreassen, S. N.; Lorente, J. S.; Xiao, B.; Pandy-Szekeres, G.; Gloriam, D.
10.1101/2025.01.11.632537 — pharmacology and toxicology — Posted on 2025-01-14
3104 Liver Lymphatic Dysfunction as a Driver of Fibrosis and Cirrhosis Progression
Jeong, J.; Hsu, S.-J.; Horikami, D.; Utsumi, T.; Yang, Y.; Arefyev, N.; Zhang, X.; Cai, S.-Y.; Boyer, J.; Garcia-Milian, R.; Tanaka, M.; McConnell, M. J.; Huang, H.-C.; Iwakiri, Y.
10.1101/2025.01.11.632552 — pathology — Posted on 2025-01-14
3105 Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes
Fialkoff, G.; Takahashi, N.; Sharkia, I.; Gutin, J.; Hermoni, N.; Kumar, R.; Pongor, L.; Nichols, S.; Sciuto, L.; Graham, C.; Desai, P.; Nirula, M.; Suresh, P.; Abel, M.; Elmeskini, R.; Maoz, M.; Rottenberg, Y.; Shoshan, N.; Nechushtan, H.; Peretz, T.; Roame, D.; Carter, P.; Hubert, A.; Cohen, J. E.; Salah, A.; Temper, M.; Grinshpun, A.; Weaver, Z.; Rajan, A.; Figg, W. D.; Zick, A.; Sadeh, R.; Friedman, N.; Thomas, A.
10.1101/2022.06.24.497386 — cancer biology — Posted on 2025-01-14
3107 Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure
Lu, L.; Fuji, K.; Guyomar, T.; Alcheikh, Y.; Lieb, M.; Andre, M.; Tanida, S.; Nonomura, M.; Hiraiwa, T.; Yennek, S.; Petzold, H.; Martin-Lemaitre, C.; Grapin-Botton, A.; Honigmann, A.; Sano, M.; Riveline, D.
10.1101/2024.02.20.581158 — biophysics — Posted on 2025-01-14
3108 Structural Basis for the Assembly of Amyloid Fibrils by the Master Cell-Signaling Regulator Human Receptor-Interacting Protein Kinase 1
Polonio, P.; Lopez-Alonso, J. P.; Jiang, H.; Escobedo-Gonzales, F. C.; Titaux-Delgado, G. A.; Ubarretxena-Belandia, I.; Mompean, M.
10.1101/2025.01.13.630173 — biophysics — Posted on 2025-01-14
3112 Biophysics-based protein language models for protein engineering
Gelman, S.; Johnson, B.; Freschlin, C.; Sharma, A.; D'Costa, S.; Peters, J.; Gitter, A.; Romero, P. A.
10.1101/2024.03.15.585128 — bioinformatics — Posted on 2025-01-14
3113 Decoding the Functional Interactome of Non-Model Organisms with PHILHARMONIC
Sledzieski, S.; Versavel, C.; Singh, R.; Ocitti, F.; Devkota, K.; Kumar, L.; Shpilker, P.; Roger, L.; Yang, J.; Lewinski, N.; Putnam, H. M.; Berger, B.; Klein-Seetharaman, J.; Cowen, L.
10.1101/2024.10.25.620267 — bioinformatics — Posted on 2025-01-14
3114 A De Novo Design Strategy to Convert FAcD from Dimer to Active Monomer
Chen, K.-W.; Wang, C.-z.; Huang, H.-s.; Wu, X.; Chen, J.-N.; Qiu, J.-H.; HOI, K. K.; Sun, T.-Y.; Wang, J.-b.; Wu, Y.-D.
10.1101/2025.01.11.632520 — bioengineering — Posted on 2025-01-14
3115 The Population Genetics of Biological Noise
Weinreich, D. M.; Sgouros, T.; Raynes, Y.; Burtsev, H.; Chang, E.; Rajakumar, S.; Bravo, I. G.; Petak, C.
10.1101/2025.01.11.632402 — evolutionary biology — Posted on 2025-01-14
3118 Seasonal and comparative evidence of adaptive gene expression in mammalian brain size plasticity
Thomas, W. R.; Richter, T.; O'Neil, E. T.; Baldoni, C.; Corthals, A. P.; von Elverfeldt, D.; Nieland, J. D.; Dechmann, D. K. N.; Hunter, R. G.; Davalos, L. M.
10.1101/2024.06.18.599531 — evolutionary biology — Posted on 2025-01-14
3122 Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients
Masuda, K.; Iketani, S.; Liu, L.; Huang, J.; Qiao, Y.; Shah, J.; McNairy, M. L.; Groso, C.; Ricupero, C.; Loffredo, L. F.; Wang, Q.; Purpura, L.; Coelho-dos-Reis, J. G. A.; Sheng, Z.; Yin, M. T.; Tsuji, M.
10.1101/2025.01.12.632164 — immunology — Posted on 2025-01-14
3123 Damage signals preferentially activate killer CD8+/- regulatory T cells to protect injured tissue
Josyula, A.; Fertil, D.; Hartigan, D. R.; Rudy, P.; Sharma, S.; Fashina, T.; Maclean, E.; Coogan, A. B.; Ngo, T. B.; Sundaresan, V.; Sadtler, K.
10.1101/2025.01.13.632166 — immunology — Posted on 2025-01-14
3125 Developmental and age-related synapse elimination is mediated by glial Croquemort
Jay, T. R.; Kang, Y.; Ouellet-Massicotte, V.; Micael, M. K. B.; Kacouros-Perkins, V. L.; Chen, J.; Sheehan, A.; Freeman, M.
10.1101/2024.06.24.600214 — neuroscience — Posted on 2025-01-14
3128 Resolution of a human super-enhancer by targeted genome randomisation
Koeppel, J.; Murat, P.; Girling, G.; Peets, E. M.; Gouley, M.; Rebernig, V.; Maheshwari, A.; Hepkema, J.; Weller, J.; Jebaraj, J. H. J.; Crawford, R.; Liberante, F. G.; Parts, L.
10.1101/2025.01.14.632548 — synthetic biology — Posted on 2025-01-14
3130 MDL-001: An Oral, Safe, and Well-Tolerated Broad-Spectrum Inhibitor of Viral Polymerases
Woods, V.; Umansky, T.; Russell, S. M.; McGovern, B. L.; Rosales, R.; Rodriguez, M. L.; van Bakel, H.; Sordillo, E. M.; Simon, V.; Garcia-Sastre, A.; White, K. M.; Smith, D. M.; Haders, D.
10.1101/2025.01.13.632836 — pharmacology and toxicology — Posted on 2025-01-14
3131 Single-Photon Single-Particle Tracking
Xu, L. W. Q.; Ronceray, N.; Mitsioni, M. F.; Radenovic, A.; Presse, S.
10.1101/2025.01.10.632389 — biophysics — Posted on 2025-01-14
3139 Genetic diversity affects ecosystem functions across trophic levels as much as species diversity, but in an opposite direction
Fargeot, L.; Poesy, C.; Lefort, M.; Prunier, J. G.; Krick, M.; Verdonck, R.; Veyssiere, C.; Richard, M.; Legrand, D.; Loot, G.; Blanchet, S.
10.1101/2024.03.27.586944 — ecology — Posted on 2025-01-14
3141 Convergence of autism proteins at the cilium
Kostyanovskaya, E.; Lasser, M. C.; Wang, B.; Schmidt, J.; Bader, E.; Buteo, C.; Arbelaez, J.; Sindledecker, A. R.; McCluskey, K. E.; Castillo, O.; Wang, S.; Dea, J.; Helde, K. A.; Graglia, J. M.; Brimble, E.; Kastner, D. B.; Ehrlich, A. T.; State, M. W.; Willsey, A. J.; Willsey, H. R.
10.1101/2024.12.05.626924 — cell biology — Posted on 2025-01-14
3144 Sex Differences in BNST Signaling and BNST CRF in Fear Processing: Implications for Unpredictable Threat in Sustained Fear
Hon, O. J.; Neira, S.; Flanigan, M. E.; Roland, A. V.; Caira, C. M.; Sides, T.; D'Ambrosio, S.; Lee, S.; Simpson, Y.; Buccini, M.; Machinski, S.; Yu, W.; Boyt, K.; Kash, T.
10.1101/2023.04.10.535848 — neuroscience — Posted on 2025-01-14
3146 ANGPTL6 variant induces cerebral vascular dysfunction and predisposes to intracranial aneurysm in mice
Baron-Menguy, C.; Freneau, M.; Mrad, M.-A.; Lebot, C.; Rio, M.; L'Allinec, V.; Quillard, T.; Desal, H.; Redon, R.; Bourcier, R.; Vion, A.-C.; Loirand, G.
10.1101/2025.01.10.632391 — physiology — Posted on 2025-01-14
3147 MISO: Microfluidic protein isolation enables single particle cryo-EM structure determination from a single cell colony
Eluru, G.; De Gieter, S.; Schenck, S.; Stroobants, A.; Shrestha, B.; Erbel, P.; Brunner, J. D.; Efremov, R. G.
10.1101/2025.01.10.632437 — biophysics — Posted on 2025-01-14
3151 CocycleHunter: cohomology-based circular gene setenrichment and genetic phase estimation in single-cell RNA-seq data.
Maggs, K.; Youssef, M. K.; Pulver, C.; Isma, J.; Nguyen, T. J.; Karthaus, W.; Hess, K.; Dotto, G. P.
10.1101/2025.01.09.632214 — bioinformatics — Posted on 2025-01-14
3152 Improved Functional Classification of Hydrolases through Pairwise Structural Similarity of Reaction Cores
Ferdous, S.; Gupta, P.; Teoh, Y. C.; Sajeevan, K. A.; SR, V.; Hainlin, K.; Reuel, N.; Qamhiyah, A.; Aluru, N. R.; Kumar, M.; Chowdhury, R.
10.1101/2025.01.09.632218 — bioinformatics — Posted on 2025-01-14
3154 Precision mRNA Nanomedicine for Targeted Vascular Therapies in ARDS and Atherosclerosis
Zhou, Z.; Zhu, J.; Yeh, C.-F.; Meliton, A.; Wu, D.; Huang, R.-T.; Shentu, T.-P.; Ray, A. G.; Wiseman, D.; Budina, E.; Alpar, A. T.; Yang, K.-C.; Hubbell, J.; Weinstock, A.; Mutlu, G. M.; Tirrell, M. V.; Fang, Y.
10.1101/2025.01.09.632179 — bioengineering — Posted on 2025-01-14
3155 Myofibroblasts reduce angiogenesis and vasculogenesis in a vascularized microphysiological model of lung fibrosis
Cambria, E.; Blazeski, A.; Ko, E. C.; Thai, T.; Dantes, S.; Barbie, D. A.; Shelton, S. E.; Kamm, R. D.
10.1101/2025.01.10.632378 — bioengineering — Posted on 2025-01-14
3157 Wildfire ash impacts to photosynthesis and growth of marine phytoplankton cultures
Van Houtan, K. S.; Lambert, J.; Provatas, A. A.; Van Houtan, D. J.; Smith, C. M.
10.1101/2025.01.10.632499 — ecology — Posted on 2025-01-14
3160 Tracking the phenology of riverine insect communities using environmental DNA
Cereghetti, E.; Ajvazi, X.; Keck, F.; Patrignani, A.; Tartini, N.; Altermatt, F.; Carraro, L.
10.1101/2025.01.10.632357 — ecology — Posted on 2025-01-14
3161 RNA helicase DDX1 regulates germinal centre selection and affinity maturation by promoting tRNA ligase activity
Kimber, R.; Ingelsfield, S.; Screen, M.; Salerno, F.; Matheson, L. S.; Okkenhaug, H.; Whale, A.; Assalaarachchi, J.; Stammers, M.; Akdeniz, D.; Andrews, S.; Ribeiro de Almeida, C.
10.1101/2025.01.10.632317 — immunology — Posted on 2025-01-14
3162 Generation of a T cell receptor, cytokine and cell repertoire synovial fluid atlas to define commonalities and dissimilarities between arthritic diseases through systems immunology approaches
Ha, M. K.; Van Deuren, V. M. L.; de Carvalho Fraga, C. A.; Hotterbeekx, A.; Dehoorne, J.; Renson, T.; Geens, E.; Aerts, N.; Heusdens, C.; Kuznetsova, M.; Van Mechelen, M.; Vanden Bulcke, M.; Hoffman, I.; Wittoek, R.; De Wachter, E.; Andrzejewski, A.; Bartholomeus, E.; de Vrij, N.; Suls, A.; Lion, E.; Vanhee, S.; Adriaensen, W.; Mullan, K.; Nakaya, H.; Kumar-Singh, S.; Laukens, K.; Joos, R.; Meysman, P.; Ogunjimi, B.
10.1101/2025.01.10.632345 — immunology — Posted on 2025-01-14
3163 Polysialylation is a general feature of immune activation
Makhsous, S.; Hunter, C.; van Eeden, C.; Osman, M.; Willis, L. M.
10.1101/2025.01.10.632476 — immunology — Posted on 2025-01-14
3164 Local delivery of SBRT and IL-12 to Murine PDAC Tumors Modulates Hematopoiesis
Vrooman, T. G.; Quarato, E. R.; Salama, N. A.; Lesch, M. L.; Hughson, A. L.; Kawano, Y.; hannon, g.; Lesser, S.; Ye, J.; Eckl, S. L.; Lord, E. M.; Linehan, D. C.; Luheshi, N.; Que, H.; Eyles, J.; Calvi, L. M.; Gerber, S. A.
10.1101/2025.01.10.632406 — immunology — Posted on 2025-01-14
3165 Improving SBRT by re-wiring immunosuppressive neutrophils in murine pancreatic ductal adenocarcinoma
Murphy, J. D.; hannon, g.; Mills, B. N.; Hughson, A. L.; Uccello, T. P.; Gavras, N. W.; Ye, J.; Belt, B. A.; Lesch, M. L.; Eckl, S. L.; Lord, E. M.; Kim, M.; Que, H.; Linehan, D.; Gerber, S. A.
10.1101/2025.01.10.632412 — immunology — Posted on 2025-01-14
3169 Warming winters, changing springs: cold hardiness dynamics predict budbreak and associated low temperature threats on an intercontinental scale
Campos-Arguedas, F.; Kirchhof, E.; North, M. G.; Londo, J. P.; Bates, T.; van Leeuwen, C.; Destrac-Irvine, A.; Bois, B.; Kovaleski, A. P.
10.1101/2025.01.09.632158 — plant biology — Posted on 2025-01-14
3171 Exploring the Role of Kv1.3 and MAPK14 in Mediating Microglial Oxidative Stress and Neuroinflammation Following Organic Dust Exposure
Massey, N.; Bhat, S. M.; Shrestha, D.; Malovic, E.; Karriker, L. A.; Choudhary, S.; Robertson, A.; Nguyen, H. M.; Wulff, H.; Kanthasamy, A.; Charavaryamath, C.
10.1101/2025.01.10.632439 — pharmacology and toxicology — Posted on 2025-01-14
3172 Age- and estrous-dependent effects of psilocybin in rats
Zylko, A. L.; Rakoczy, R. J.; Roberts, B. F.; Wilson, M.; Powell, A.; Heitkamp, M.; Fiest, D.; Jones, J. A.; McMurray, M. S.
10.1101/2025.01.10.632408 — pharmacology and toxicology — Posted on 2025-01-14
3174 Small molecule promoters of endogenous lipid droplet accumulation drive lysophagy
Vechalapu, S. K.; Duraisamy, S.; Senthil, S.; Kumar, R.; Ajnar, D.; Draksharapu, A.; Kumar, S.; ALLIMUTHU, D.
10.1101/2025.01.10.632143 — cancer biology — Posted on 2025-01-14
3175 Recurrent oncogenic ZC3H18 mutations stabilize endogenous retroviral RNA
Tanu, T.; Cox, A. M.; Karlow, J.; Sharma, P.; He, X.; Wu, C.; Babu, S.; Brown, J.; Brown, K. M.; Chanock, S. J.; Liu, D.; Zhang, T.; Burns, K. H.; Boutz, P. L.; Insco, M. L.
10.1101/2025.01.10.632423 — cancer biology — Posted on 2025-01-14
3176 Inhibition of Glutamine Metabolism Suppresses Tumor Progression through Remodeling of the Macrophage Immune Microenvironment
Li, T.; Akhtarkhavari, S.; Chang, T.-Y.; Shen, Y.-A.; Yang, J.; Slusher, B.; Shih, I.-M.; Gaillard, S.; Wang, T.-L.
10.1101/2025.01.10.632174 — cancer biology — Posted on 2025-01-14
3177 Highly potent novel multi-armoured IL13Rα2 CAR-T subverts the immunosuppressive microenvironment of Glioblastoma
Mangolini, M.; Srivastava, S.; Souster, E.; Yang, Y.; Wang, H.; Karattil, R.; Schultz, L.; Ma, B.; Pombal, D.; Greenig, M.; Ramon, A.; Sormanni, P.; Cordoba, S.; Onuoha, S.
10.1101/2025.01.10.632392 — cancer biology — Posted on 2025-01-14
3178 Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targeting
Sandulache, V. C.; Yadollahi, P.; McCord, K. A.; Li, Y.; Dayoub, H.; Saab, K.; Essien, F. N.; Hyslop, S.; Kan, E.; Ahmed, M. K.; Kirby, P. R.; Putluri, V.; Ambati, C.; Kami Reddy, R. K.; Castro, P. D.; Skinner, H. D.; Coarfa, C.; Decker, W. K.; Osman, A. A.; Patel, R. U.; Myers, J. N.; Lai, S. Y.; Putluri, N.; Johnson, F. M.; Frederick, M. J.; William, H. H.
10.1101/2025.01.10.632413 — cancer biology — Posted on 2025-01-14
3179 Neuronal cell adhesion molecule (NRCAM) variant defined by microexon skipping is an essential, antigenically distinct, and targetable surface proteoform in high-grade glioma
Sehgal, P.; Naqvi, A. S.; Higgins, M.; Liu, J.; Harvey, K.; Jarroux, J.; Kim, T.; Mankaliye, B.; Mishra, P.; Watterson, G.; Fine, J.; Davis, J.; Hayer, K. E.; Castro, A.; Mogbo, A.; Drummer, C.; Martinez, D.; Koptyra, M. P.; Ang, Z.; Wang, K.; Farrel, A.; Quesnel-Vallieres, M.; Barash, Y.; Spangler, J. B.; Rokita, J. L.; Resnick, A. C.; Tilgner, H. U.; DeRaedt, T.; Powell, D. J.; Thomas-Tikhonenko, A.
10.1101/2025.01.09.631916 — cancer biology — Posted on 2025-01-14
3180 Anticancer synthetic arylsulfonamides with Wnt1-modulating activity
Gutti, M.; Luo, J.; Sharma, V.; Lee, E.; Desarkar, A.; Raval, R.; Soedarmono, A.; Zhu, J.; Njoo, E.
10.1101/2025.01.11.632297 — cancer biology — Posted on 2025-01-14
3181 Light-induced conformational switching and magnetic sensitivity of Drosophila cryptochrome
Chandler, S. A.; Gehrckens, A. S.; Shah, L. M. N.; Buckton, K. E.; Cao, G.; Sen, N.; Zollitsch, T.; Rodriguez, R.; Solov'yov, I.; Schleicher, E.; Weber, S.; Hore, P. J.; Timmel, C. R.; Mackenzie, S. R.; Benesch, J. L.
10.1101/2025.01.10.632489 — biophysics — Posted on 2025-01-14
3183 A low-complexity linker as a driver of intra- and intermolecular interactions in DNAJB chaperones
Hobbs, B.; Limmer, N.; Ossa, F.; Knupling, E.; Lenton, S.; Fodera, V.; Kalverda, A. P.; Karamanos, T.
10.1101/2025.01.10.632390 — biophysics — Posted on 2025-01-14
3189 High-throughput Mucus Microrheology for Phenotyping and Disease Modeling
Ling, F.; Sahin, A. T.; Miller Naranjo, B.; Aime, S.; Roth, D.; Tepho, N.; Vendrame, A.; Emken, E.; Kiechle, M.; Tesfaigzi, Y.; Lieleg, O.; Nawroth, J. C.
10.1101/2025.01.09.632077 — bioengineering — Posted on 2025-01-14
3190 Real-time simultaneous monitoring of multiple analytes in bacterial cultures
Fink, M. M.; Aljuboori, Z.; Klaers, M.; Underdue, M.; Malkovsky, J.; Rizk, S. S.
10.1101/2025.01.10.632470 — bioengineering — Posted on 2025-01-14
3192 Pre-clinical validation of in vitro engineered but cell-free human tissue grafts for skeletal regeneration
Garcia Garcia, A.; Prithiviraj, S.; Raina, D. B.; Schmidt, T.; Baudet-Quintino, A.; Gonzalez Anton, S.; Rabanal Cajal, L.; Kahn, R.; Tagil, M.; Bourgine, P. E.
10.1101/2025.01.10.632347 — bioengineering — Posted on 2025-01-14
3196 The Role of Genetic Variation in Shaping Phenotypic Responses to Diet in Aging Drosophila melanogaster
Bak, N. K.; Mackay, T. F. C.; Morgante, F.; Nielsen, K. L.; Nielsen, J. L.; Kristensen, T. N.; Rohde, P. D.
10.1101/2025.01.09.632132 — genetics — Posted on 2025-01-14
3199 A proteo-transcriptomic investigation of toxin evolution in planarians and their role in flatworm terrestrialization
Garcia-Vernet, R.; Benitez-Alvarez, L.; Palma-Guerrero, J.; Chiva, C.; Eleftheriadi, K.; Rojo, I.; Sabido, E.; Fernandez, R.
10.1101/2025.01.09.632098 — evolutionary biology — Posted on 2025-01-14
3200 Larger larval sea lamprey (Petromyzon marinus) have longer survival times when exposed to the lampricide 3-trifluoromethyl-4-nitrophenol
Nalesnik, A. M.; Martin, E. L.; Kovacs, I. S.; Johnson, C. S.; Carroll, E. I.; Jubar, A.; Hemstrom, W.; Wilkie, M. P.; Dunlop, E. S.; Sepulveda, M. S.; Johnson, N. S.; Christie, M. R.
10.1101/2025.01.10.632359 — evolutionary biology — Posted on 2025-01-14
3203 Phenological turnover matters when making trait-based predictions of plant-pollinator interactions
Cantwell-Jones, A. R.; Everson, J.; Bates, O.; Al-Hayali, A.; Allen, G.; Berard, L.; Celiebe, F.; Egleston, S.; Hudson, L.; James, J.; Jung, L.; Kattan, M.; Lejeune, R.; Svedin, J.; van Brakel, S.; van Unen, M.; Tylianakis, J. M.; Larson, K.; Gill, R. J.
10.1101/2025.01.10.632321 — ecology — Posted on 2025-01-14
3205 Tissue-resident skeletal muscle macrophages promote recovery from viral pneumonia-induced sarcopenia in normal aging.
Runyan, C. E.; Luo, L.; Welch, L. C.; Lu, Z.; Chen, F.; Schleck, M. J.; Nafikova, R. A.; Grant, R. A.; Piseaux Aillon, R.; Senkow, K. J.; Bunyan, E. G.; Plodzeen, W. T.; Weiss, C.; Dada, L. E.; Thorp, E. B.; Sznajder, J. I.; Chandel, N. S.; Misharin, A. V.; Budinger, G. S.
10.1101/2025.01.09.631996 — immunology — Posted on 2025-01-14
3206 Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds.
Meunier, D.; Corona-Torres, R.; Boulton, K.; Wu, Z.; Ballantyne, M.; Glendinning, L.; Ahmad, A. A.; Borowska, D.; Taylor, L.; Vervelde, L.; del Pozo, J.; Vasilogianni, M.; Jaramillo-Ortiz, J.; Sanchez-Arsuaga, G.; Psifidi, A.; Tomley, F.; Watson, K. A.; McGrew, M. J.; Stevens, M. P.; Blake, D. P.; Hume, D. A.
10.1101/2025.01.10.632125 — immunology — Posted on 2025-01-14
3207 CD2 expression is co-regulated with stemness- and exhaustion-associated factors in human T cells
Demetriou, P.; Iakovou, M.; Gregoriou, G.; Vrachnos, D.; Chi, J.; Tamamouna, V.; Constantinou, S.; Papanastasiou, V.; Antoniades, A.; Costeas, P.
10.1101/2025.01.10.632071 — immunology — Posted on 2025-01-14
3210 The secreted redox sensor roGFP2-Orp1 reveals oxidative dynamics in the plant apoplast
Ingelfinger, J.; Zander, L.; Seitz, P. L.; Trentmann, O.; Tiedemann, S.; Sprunck, S.; Dresselhaus, T.; Meyer, A. J.; Müller-Schüssele, S. J.
10.1101/2025.01.10.632316 — plant biology — Posted on 2025-01-14
3211 ATP-sensitive isoforms of P2X5: A reevaluation of its function across species
Yang, X.-N.; Wang, D.-P.; Shen, C.-H.; Chen, X.; Yang, H.; Zhou, X.; Guo, C.-R.; Tian, Y.; Zhu, M. X.; Yu, Y.
10.1101/2025.01.10.632374 — physiology — Posted on 2025-01-14
3212 Long-term patient-derived ovarian cancer organoids closely recapitulate tumor of origin and clinical response
Thorel, L.; Dolivet, E.; Morice, P.-M.; Florent, R.; Divoux, J.; Perreard, M.; Lecouflet, L.; Desmartin, G.; Marde Alagama, C.; Giffard, F.; Leconte, A.; Lequesne, J.; Clarisse, B.; Briand, M.; Traore, A.; Villenet, C.; Meneboo, J.-P.; Babin, G.; Gaichies, L.; Martin-Francoise, S.; Le Brun, J.-F.; Rouzier, R.; Brotin, E.; Denoyelle, C.; Vigneron, N.; Leman, R.; Vaur, D.; Castera, L.; Jeanne, C.; Blanc-Fournier, C.; Elie, N.; Plancoulaine, B.; Joly, F.; Meryet-Figuiere, M.; Figeac, M.; Weiswald, L.-B.; Poulain, L.
10.1101/2025.01.10.631512 — cancer biology — Posted on 2025-01-14
3213 Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells
Cooke, S. F.; Wright, T. A.; Lappin, G.; Kyurkchieva, E.; Sin, Y. Y.; Ling, J.; Zorn, A.; O'Gorman, B.; Banyard, W.; Chang, C.-J.; Wheadon, H.; Huang, D. T.; Baillie, G. S.; Blair, C. M.
10.1101/2025.01.10.632324 — cancer biology — Posted on 2025-01-14
3214 The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage.
Efthymiou, G.; Compare, C.; Lohmann, E.; Kousteridou, P.; Bertrand, P.; Carr, H.; Ben-Sahra, I.; Nemazanyy, I.; Tubiana, S.-S.; Hussain, Z.; Finetti, P.; Bertucci, F.; Bidaut, G.; Lachaud, C.; Guillaumond, F.; Tomasini, R.; Vasseur, S.
10.1101/2025.01.10.631286 — cancer biology — Posted on 2025-01-14
3217 Cleanet: robust doublet detection in cytometry data based on protein expression patterns
Ionita, M.; McKeague, M. L.; Painter, M. M.; Mathew, D. M.; Pattekar, A.; Maseda, D.; Wherry, E. J.; Greenplate, A. R.
10.1101/2025.01.09.632259 — bioinformatics — Posted on 2025-01-14
3220 Long-Read Low-Pass Sequencing for High-Resolution Trait Mapping
Lee, K. C.; Korani, W.; Bentz, P. C.; Pokhrel, S.; Ozias-Akins, P.; Harkess, A.; Vaughn, J.; Clevenger, J.
10.1101/2025.01.09.632261 — genetics — Posted on 2025-01-14
3221 Entrenchment and contingency in neutral protein evolution with epistasis
Schmelkin, L.; Carnevale, V.; Haldane, A.; Townsend, J. P.; Chung, S.; Levy, R. P.; Kumar, S.
10.1101/2025.01.09.632266 — evolutionary biology — Posted on 2025-01-14
3222 The interplay of uncertainty, relevance and learning influences auditory categorization
Sheth, J.; Collina, J.; Piasini, E.; Kording, K. P.; Cohen, Y.; Geffen, M. N.
10.1101/2022.12.01.518777 — neuroscience — Posted on 2025-01-14
3225 The Mutated p.H222P A-type Lamins Drive Loxl2-Mediated Extracellular Matrix Remodeling in Both Patient-Derived Cardiomyocytes and Mouse Models of Dilated Cardiomyopathy
Kervella, M.; Peccate, C.; Guesmia, Z.; Grandi, F. C.; Mougenot, N.; Forand, A.; Charrabi, A.; Brochier, G.; Andriantsitohaina, R.; Meli, A. C.; Muchir, A.
10.1101/2025.01.10.632312 — pathology — Posted on 2025-01-14
3227 Integrated Techniques for Extracellular Particle Separation and Single-Particle Multiparametric Characterization to Track Cancer Biomarkers from Tissue to Biofluids
Nguyen, K. T.; Xia, J.; Chang, C.; Hade, M. D.; Rima, X. Y.; An, J. Y.; Min, B. H.; Nagaraj, C. K.; Wang, L.; Huang, T. J.; Li, F. K.; Kim, Y.; Wong, D.; Reategui, E.
10.1101/2025.01.09.632270 — cancer biology — Posted on 2025-01-14
3229 Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects
Vigneron, S. F.; Ohno, S.; Braz, J.; Kim, J. Y.; Kweon, O. S.; Webb, C.; Billesbolle, C.; Bhardwaj, K.; Irwin, J. J.; Manglik, A.; Basbaum, A. I.; Ellman, J. A.; Shoichet, B. K.
10.1101/2025.01.09.632033 — biophysics — Posted on 2025-01-14
3232 WITHDRAWN: Structural Enzymology, Phylogenetics, Differentiation, and Symbolic Reflexivity at the Dawn of Biology
Carter, C. W.; Tang, G. Q.; Patra, S. K.; Betts, L.; Dieckhaus, H.; Kuhlman, B.; Douglas, J.; Wills, P.; Bouckaert, R.; Popovic, M.; Ditzler, M.
10.1101/2024.12.17.628912 — evolutionary biology — Posted on 2025-01-14
3233 WARMING AND INCREASED RAINFALL REDUCE BUMBLEBEE QUEEN FITNESS
Archer, C. R.; Schmid-Hempel, P.; Schmid-Hempel, R.; Bayer-Wilfert, L.
10.1101/2025.01.09.632115 — ecology — Posted on 2025-01-14
3234 ATG9 vesicles are a subtype of intracellular nanovesicle
Fesenko, M.; Moore, D. J.; Ewbank, P.; Courthold, E.; Royle, S. J.
10.1101/2024.09.12.612637 — cell biology — Posted on 2025-01-14
3235 Hypoxia-inducible factor 2α promotes protective Th2 cell responses during intestinal helminth infection
Labuda, J. C.; Olsen, T. M.; Verma, S.; Kimmel, S.; Edwards, T. H.; Dufort, M. J.; Harrison, O. J.
10.1101/2025.01.09.631414 — immunology — Posted on 2025-01-14
3236 A synthetic cell with integrated DNA self-replication and membrane biosynthesis
Restrepo Sierra, A. M.; Ramirez Gomez, F.; van Tongeren, M.; Sierra Heras, L.; Danelon, C.
10.1101/2025.01.14.632951 — synthetic biology — Posted on 2025-01-14
3238 Role of drug induced nuclear CTSL (nCTSL) in DNA damage response in cancer- therapeutic implications
Thirusangu, P.; Jin, L.; Ray, U.; Zhao, A.; Wu, X.; Hou, X.; VanBlaricom, J. L.; Aalam, S. M. M.; Oberg, A. L.; Kannan, N.; Weroha, J.; Chien, J.; Kaufmann, S. H.; Bakkum-Gamez, J. N.; Shridhar, V.
10.1101/2025.01.09.632284 — cancer biology — Posted on 2025-01-14
3239 Image-based 3D active sample stabilization on the nanometer scale for optical microscopy
Vorlaufer, J.; Semenov, N.; Kreuzinger, C.; Javoor, M. G.; Zens, B.; Agudelo, N.; Tavakoli, M. R.; Suplata, M.; Jahr, W.; Lyudchik, J.; Wartak, A.; Schur, F. K.; Danzl, J. G.
10.1101/2025.01.10.629211 — biophysics — Posted on 2025-01-14
3243 Cryo-EM captures early intermediate steps in dynein activation by LIS1
Nguyen, K. H. V.; Karasmanis, E. P.; Kendrick, A. A.; Reck-Peterson, S. L.; Leschziner, A. E.
10.1101/2025.01.10.632485 — biophysics — Posted on 2025-01-14
3248 A reference-quality NLRome for the hexaploid sweetpotato and diploid wild relatives
Parada-Rojas, C. H.; Childs, K. L.; Fernandez de Soto, M.; Salcedo, A.; Pecota, K.; Yencho, G. C.; Almeyda, C.; Kitavi, M.; Buell, C. R.; Conant, G. C.; Baltzegar, D.; Quesada-Ocampo, L. M.
10.1101/2025.01.13.632774 — plant biology — Posted on 2025-01-14
3250 Evaluation of the Prognostic Value of Four ECM-Associated Genes in Recurrence and Metastasis of Colorectal Cancer
Avcıoglu, B. S. D.; Charyyeva, S.; Erdogan, B. D.; Kaymaz, O.; Durhan, A.; Aksel, B.; Yazıcı, O.; Savas, B.; Ensari, A.; Kıvrak, H.; Engin, E. D.; Belder, N.; Özdag, H.
10.1101/2025.01.13.632700 — cancer biology — Posted on 2025-01-14
3252 Chloroform release from ageing cells and Drosophila DJ-1 mutants
Issitt, T.; Johnston, T.; Ugbode, C.; Grumulaityte, J.; Harmens, A.; Brackenbury, W. J.; Sweeney, S. T.; Redeker, K.
10.1101/2025.01.13.632713 — biochemistry — Posted on 2025-01-14
3253 Identification of Inhibitors of Chikungunya virus nsP2 ATPase
Navarro, H.; Scott, J. E.; Smith, G. R.; Ghiabi, P.; Gibson, E.; Loppnau, P.; Harding, R. J.; Hossain, M. A.; Bose, M. R.; Pearce, K. H.; Merten, E. M.; Willson, T. M.; Brown, P. J.
10.1101/2024.12.02.625520 — biochemistry — Posted on 2025-01-14
3257 Atlas of plasma metabolic markers linked to human brain morphology
van der Meer, D.; Kopal, J.; Shadrin, A.; Fuhrer, J.; Rokicki, J.; Stinson, S.; Djurovic, S.; Dale, A.; Andreassen, O.
10.1101/2025.01.12.632645 — neuroscience — Posted on 2025-01-14
3258 Individualized Phenotyping of Functional ALS Pathology in Sensorimotor Cortex
Kalyani, A.; Northall, A.; Schreiber, S.; Bruggemann, J.; Vielhaber, S.; Al Dubai, M.; Bin Ramadan, A.; Mattern, H.; Speck, O.; Reichert, C.; Kuehn, E.
10.1101/2025.01.13.632667 — neuroscience — Posted on 2025-01-14
3260 Fine root endophytes forming winter mycorrhiza
Sentoku, T.; Komatsuda, Y.; Shimada, H.; Arai, M.; Kobae, Y.
10.1101/2025.01.10.632310 — plant biology — Posted on 2025-01-14
3261 Haplotype-resolved genome assembly of the tetraploid potato cultivar Desiree
Godec, T.; Beier, S.; Rodriguez-Granados, N. Y.; Sasidharan, R.; Abdelhakim, L.; Teige, M.; Usadel, B.; Gruden, K.; Petek, M.
10.1101/2025.01.14.631659 — plant biology — Posted on 2025-01-14
3262 Biosynthesis and Bioactivity of Anti-Inflammatory Triterpenoids in Calendula officinalis (pot marigold)
Golubova, D.; Salmon, M.; Su, H.; Tansley, C.; Kaithakottil, G. G.; Linsmith, G.; Schudoma, C.; Swarbreck, D.; O'Connell, M. A.; Patron, N. J.
10.1101/2025.01.11.632544 — plant biology — Posted on 2025-01-14
3264 Effector-triggered processing body formation attenuates host translation via ER stress responses and autophagy upon bacterial infection
Gonzalez-Fuente, M.; Schulz, N.; Abdrakhmanov, A.; Izzati, G.; Zhu, S.; Langin, G.; Gouguet, P.; Franz-Wachtel, M.; Macek, B.; Hafren, A.; Dagdas, Y.; Üstün, S.
10.1101/2025.01.09.632196 — plant biology — Posted on 2025-01-14
3266 Geometry effects on protein mobility in a synapse
Dannenberg, S.; Reshetniak, S.; Mohammadinejad, S.; Rizzoli, S.; Klumpp, S.
10.1101/2025.01.12.632582 — biophysics — Posted on 2025-01-14
3270 Weak and tunable adhesion-clutch drives rapid cell migration and glioblastoma motility
Baba, K.; Fukushi-Kumagaya, A.; Morisaki, M.; Takeuchi, R.; Xiao, Z.; Nagashima, Y.; Sakai, M.; Higashiguchi, Y.; Katsuno-Kambe, H.; Katsuma, A.; Ueda, Y.; Kamioka, Y.; Daisuke, K.; Kinashi, T.; Kanemura, Y.; Inagaki, N.
10.1101/2025.01.13.632873 — cell biology — Posted on 2025-01-14
3271 DUSP12 promotes cell cycle progression and protects cells from cell death by regulating ZPR9
Abdusamad, M.; Guo, X.; Ramirez, I.; Velasquez, E. F.; Cohn, W.; Gholkar, A. A.; Whitelegge, J. P.; Torres, J. Z.
10.1101/2025.01.13.632830 — cell biology — Posted on 2025-01-14
3277 High radiosensitivity in Norway spruce (Picea abies) is rendered by less comprehensive mobilisation of protection, repair and stress responses compared to the radiotolerant Arabidopsis thaliana
Bhattacharjee, P.; Blagojevic, D.; Lee, Y.; Gillard, G. B.; Gronvold, L.; Hvidsten, T. R.; Sandve, S. R.; Lind, O. C.; Salbu, B.; Brede, D. A.; Olsen, J. E.
10.1101/2023.11.20.562501 — plant biology — Posted on 2025-01-14
3278 A Narrow Range of Transcript-error Rates Across the Tree of Life
Li, W.; Baehr, S.; Marasco, M.; Reyes, L.; Brister, D.; Pikaard, C.; Gout, J.-F.; Vermulst, M.; Lynch, M.
10.1101/2023.05.02.538944 — evolutionary biology — Posted on 2025-01-14
3280 Benchmarking unsupervised methods for inferring TCR specificity
Jouannet, C.; Vantomme, H.; Klatzmann, D.; Mariotti-Ferrandiz, E.
10.1101/2024.10.26.620398 — immunology — Posted on 2025-01-14
3281 Single neuron diversity supports area functional specialization along the visual cortical pathways
Feyerabend, M.; Pommer, S.; Jimenez-Sosa, M. S.; Rachel, J.; Sunstrum, J. K.; Preuss, F.; Mestern, S.; Hinkel, R.; Mietsch, M.; Viyajraghavan, S.; Everling, S.; Treue, S.; Arnsten, A. F.; Lewis, D. A.; Wolf, F.; Murray, J.; Muller, L.; McCarroll, S.; Krienen, F.; Datta, D.; Wang, X. J.; Tripathy, S.; Gonzalez-Burgos, G.; Inoue, W.; Neef, A.; Staiger, J. F.; Martinez-Trujillo, J. C.
10.1101/2024.12.13.628359 — neuroscience — Posted on 2025-01-14
3282 FGFR1 inhibition prevents metabolic adaptation associated with therapy resistance in glioblastoma
Duran, R. V.; Zarzuela, L.; Lopez-Cepero, I. G.; Rattigan, K. M.; Sanchez-Escabias, E.; Morillo-Huesca, M.; Reina-Bando, A.; Oltra, S. S.; Sierra-Parraga, J.; Ceballos-Chavez, M.; Capilla-Gonzalez, V.; Moreno-Bueno, G.; Murdoch, P. d. S.; Reyes, J. C.; Helgason, V.; Tome, M.
10.1101/2025.01.11.632515 — cancer biology — Posted on 2025-01-14
3287 Insights into the FOXE3 Transcriptional Network and Disease Mechanisms from the Investigation of a Regulatory Variant Driving Complex Microphthalmia
Plaisancie, J.; Angee, C.; Erjavec, E.; Raymond-Letron, I.; Douet, J.-Y.; Goetz, M.; Vincent-Delorme, C.; Karemaker, I. D.; Baltissen, M.; Vermeulen, M.; Valdivia, L.; Jabot-Hanin, F.; David, P.; Hadjadj, D.; Monsef, Y. A.; Lyazrhi, F.; Calvas, P.; Rozet, J.-M.; Chassaing, N.; Fares-Taie, L.
10.1101/2025.01.13.632782 — genetics — Posted on 2025-01-14
3289 Microscopy Nodes: versatile 3D microscopy visualization with Blender
Gros, O.; Bhickta, C.; Lokaj, G.; Schwab, Y.; Köhler, S.; Banterle, N.
10.1101/2025.01.09.632153 — cell biology — Posted on 2025-01-14
3290 GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration
Albers, D.; Novikova, S.; Vieyto-Nunez, J.; Almeida-Hernandez, Y.; Pastorio, C.; Klassen, F.; Weiss, D.; von Maltitz, P.; Jaikishan, J.; Datta, M.; Jumaa, H.; Jebaraj, B.; Stilgenbauer, S.; Kumar, M.; Maity, P. C.; Buske, C.; Stifel, U.; Zinngrebe, J.; Fischer-Posovszky, P.; Chevigne, A.; Kirchhoff, F.; Sanchez-Garcia, E.; Muench, J.; Harms, M.
10.1101/2025.01.13.632759 — cell biology — Posted on 2025-01-14
3298 miR-379-3p counteracts cancer cachexia through regulation of pyrimidinergic receptor, mitochondrial stress and interferon response.
Borja-Gonzalez, M.; Gonzalez-Ojeda, R.; Sannicandro, A. J.; Su, C.; McCarthy, E. C.; Sanz-Nogues, C.; Dwyer, R. M.; McDonagh, B.; Goljanek-Whysall, K.
10.1101/2025.01.11.632559 — cancer biology — Posted on 2025-01-14
3300 A prime editing strategy to rewrite the γ-globin promoters and reactivate fetal hemoglobin for sickle cell disease
Chalumeau, A.; Bou Dames, M.; Antoniou, P.; Loganathan, P.; Mombled, M.; Corre, G.; Peterka, M.; Amendola, M.; Giovannangeli, C.; Maresca, M.; Miccio, A.; Brusson, M.
10.1101/2025.01.13.632780 — molecular biology — Posted on 2025-01-14
3301 RBM20-variants induce distinct calcium handling and metabolic phenotypes in patient-specific stem cell models of dilated and non-compaction cardiomyopathy
Rebs, S.; Sedaghat-Hamedani, F.; Kayvanpour, E.; Dudek, J.; Berecic, B.; Eberl, H.; Huebscher, D.; Reich, C.; Klein, T.; Doose, S.; Nikolaev, V. O.; Guan, K.; Hasenfuss, G.; Sauer, M.; Tiburcy, M.; Maack, C.; Meder, B.; Streckfuss-Boemeke, K.
10.1101/2025.01.13.632728 — molecular biology — Posted on 2025-01-14
3302 Omics-based insights into human liver reveal GTPase-driven mechanisms of MASLD progression in obesity
Zhao, Q.; de Nardo, W.; Wang, R.; Zhong, Y.; Keles, U.; Zhao, L. N.; Tay, H.; Youhanna, S.; Yan, M.; Xie, Y.; Kim, Y.; Lee, S.; Lim, R. L.; Teo, G.; Naraya, P.; Burton, P. R.; Lauschke, V. M.; Choi, H.; Watt, M. J.; Kaldis, P.
10.1101/2025.01.13.632747 — molecular biology — Posted on 2025-01-14
3303 Combinatorial phosphorylation on CTD of RNA polymerase II selectively controls transcription and export of protein-coding mRNAs
Panina, S. B.; Irani, S.; Hardtke, H. A.; Stephenson, R.; Floyd, B. M.; Moreno, R. Y.; Marcotte, E. M.; Zhang, Q.; Zhang, Y. J.
10.1101/2025.01.13.632769 — molecular biology — Posted on 2025-01-14
3305 Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3
Umhoefer, J. M.; Arce, M. M.; Whalen, S.; Dajani, R.; Goudy, L.; Kasinathan, S.; Belk, J. A.; Zhang, W.; Zhou, R.; Subramanya, S.; Hernandez, R.; Tran, C.; Kirthivasan, N.; Freimer, J. W.; Mowery, C. T.; Nguyen, V.; Ota, M.; Gowen, B. G.; Simeonov, D. R.; Curie, G. L.; Li, Z.; Corn, J. E.; Chang, H. Y.; Gilbert, L. A.; Satpathy, A. T.; Pollard, K. S.; Marson, A.
10.1101/2024.08.30.610436 — immunology — Posted on 2025-01-14
3306 Secreted Clever-1 Modulates T Cell Responses and Impacts Cancer Immunotherapy Efficacy
Prince, S.; Viitala, M.; Sjöroos, R.; Bendes, A. A.; Rannikko, J. H.; Patten, D. A.; di Benedetto, I.; Tyni, L.; Figueiredo, C. R.; Koskivuo, I.; Salminen, T. A.; Shetty, S.; Hollmen, M.
10.1101/2024.10.23.619796 — immunology — Posted on 2025-01-14
3309 Development of FAP-targeted theranostics discovered by next-generation sequencing-augmented mining of a novel immunized VNAR library
Gunaratne, G.; Gallant, J.; Ott, K.; Broome, P.; Celeda, S.; West, J.; Aluicio-Sarduy, E.; Engle, J.; Mixdorf, J.; Boros, E.; Meimetis, L.; Lang, J.; Zhao, S.; Hernandez, R.; Kosoff, D.; LeBeau, A.
10.1101/2025.01.13.632555 — synthetic biology — Posted on 2025-01-14
3310 A Vascularized Liver Microphysiological System Captures Key Features of Hepatic Insulin Resistance and Monocyte Infiltration
Tevonian, E. N.; Kan, E. L.; Maniar, K. K.; Wang, A. J.; Datta, A.; Kamm, R. D.; Lauffenburger, D. A.; Griffith, L. G.
10.1101/2025.01.09.632182 — bioengineering — Posted on 2025-01-14
3311 Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
Sitron, C. S.; Trinkaus, V. A.; Galesic, A. G.; Garhammer, M.; Yuste Checa, P.; Dransfeld, U.; Feigenbutz, D.; Zhang, J.; Dudanova, I.; Harper, J. W.; Hartl, F. U.
10.1101/2025.01.13.632710 — biochemistry — Posted on 2025-01-13
3312 Structures of vesicular stomatitis virus glycoprotein G alone and in complex with a neutralizing antibody
Minoves, M.; OuldAli, M.; belot, l.; roche, s.; zarkadas, e.; Schoehn, G.; Gaudin, Y.; ALBERTINI, A.
10.1101/2025.01.13.632142 — biochemistry — Posted on 2025-01-14
3313 Two Transport Routes for Fetuin-A-based Mineral Complexes in Osteogenic Matrix Mineralization
Schaart, J. M.; Rutten, L.; To, S. V.; Shah, A. A.; Martens, M.; Macias-Sanchez, E.; Jahnen-Dechent, W.; Sommerdijk, N.; Akiva, A.
10.1101/2025.01.13.632733 — biochemistry — Posted on 2025-01-14
3315 ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major.
Almeida Da Silva, G. L.; Damasceno, J. D.; Black, J. A.; McCulloch, R.; Tosi, L. R. O.
10.1101/2025.01.13.632695 — molecular biology — Posted on 2025-01-13
3316 ATG-3 limits Orsay virus infection in C. elegans through regulation of collagen pathways
Kalugotla, G.; Marmerstein, V.; Schriefer, L. A.; Wang, L.; Morrison, S.; Casorla Perez, L.; Schedl, T.; Pak, S. C.; Baldridge, M. T.
10.1101/2025.01.13.632696 — microbiology — Posted on 2025-01-13
3318 Genomic insights into six clinical isolates of Stenotrophomonas maltophilia from Northern India
Gheewalla, N.; Jadhav, Y.; Jagannadham, J.; Tyagi, A.; Budhiraja, S.; TARAI, B.; Karve, S. M.
10.1101/2025.01.13.632882 — microbiology — Posted on 2025-01-13
3319 Overturning circulation structures the microbial functional landscape of the South Pacific
Kolody, B. C.; Sachdeva, R.; Zheng, H.; Fussy, Z.; Tsang, E.; Sonnerup, R. E.; Purkey, S. G.; Allen, E. E.; Banfield, J. F.; Allen, A. E.
10.1101/2025.01.12.631543 — microbiology — Posted on 2025-01-13
3325 Unveiling the Evolution of Antimicrobial Peptides in Gut Microbes via Foundation Model-Powered Framework
LI, W.; Huang, B.; Guo, M.; Zeng, Z.; Cai, T.; Feng, L.; Zhang, X.; Guo, L.; Jiang, X.; Yin, Y.; Wang, E.; Huang, X.; Zheng, J.
10.1101/2025.01.13.632881 — microbiology — Posted on 2025-01-13
3327 Spatially-divergent metabolic impact of experimental toxoplasmosis: immunological and microbial correlates
Lesani, M.; Middleton, C. E.; Feng, T.-Y.; Arroyo, J. C. U.; Casarez, E.; Ewald, S. E.; McCall, L.-I.
10.1101/2025.01.13.632649 — microbiology — Posted on 2025-01-13
3329 VZV gE Promotes STING Degradation via Midnolin-Proteasome Pathway to Inhibit cGAS-STING Signaling
Chen, L.; Dai, L.; Nie, S.; Zhao, Y.; Li, F.; Deng, X.; Liu, C.; Li, M.; Luo, Z.; Liu, Y.; Ge, W.; Liu, X.; Yi, Q.; Li, Y.; Pan, P.; Wang, X.
10.1101/2025.01.13.632693 — microbiology — Posted on 2025-01-14
3332 Linkage-based ortholog refinement in bacterial pangenomes with CLARC
Ojeda, I. G.; Palace, S. G.; Martinez, P. P.; Azarian, T.; Grant, L. R.; Hammitt, L.; Hanage, B.; Lipsitch, M.
10.1101/2024.12.18.629228 — bioinformatics — Posted on 2025-01-13
3334 Structural basis of directionality control in large serine integrases
Shin, H.; Pigli, Y.; Pena Reyes, T.; Fuller, J. R.; Olorunniji, F. J.; Rice, P. A.
10.1101/2025.01.03.631226 — biochemistry — Posted on 2025-01-13
3335 DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project
Mariner, B. L.; McCoy, B. M.; Greenier, A.; Brassington, L.; Slikas, E.; Adjangba, C.; Marye, A.; Harrison, B. R.; Bamberger, T.; Algavi, Y.; Muller, E.; Harris, A.; Rout, E.; The Dog Aging Project Consortium, ; Avery, A.; Borenstein, E.; Promislow, D.; Snyder-Mackler, N.
10.1101/2024.10.08.617286 — genomics — Posted on 2025-01-13
3336 TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions
Perry, C. H.; Lavado, A.; Thulabandu, V.; Ramirez, C.; Pare, J.; Dixit, R.; Mishra, A.; Yang, J.; Yu, J.; Cao, X.
10.1101/2024.12.19.629472 — developmental biology — Posted on 2025-01-13
3337 A novel genetic fluorescent reporter to visualize mitochondrial nucleoids
Deng, J.; Swift, L.; Zaman, M.; Sharma, A.; Bureik, D.; Padovani, F.; Benedikt, A.; Shahhosseini, F.; Jaiswal, A.; Brideau, C.; Grewal, S.; Schmoller, K. M.; Colarusso, P.; Shutt, T. E.
10.1101/2023.10.23.563667 — cell biology — Posted on 2025-01-13
3340 Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
Trinh, V. Q.-H.; Ankenbauer, K. E.; Torbit, S. M.; Liu, J.; Batardiere, M.; Kumar, B.; Maurer, H. C.; Revetta, F.; Chen, Z.; Kruse, A.; Judd, A.; Copeland, C.; Wong, J.; Ben-Levy, O.; Jarvis, B.; Brown, M.; Brown, J. W.; Das, K.; Makino, Y.; Spraggins, J. M.; Lau, K.; Azadi, P.; Maitra, A.; Tan, M. C. B.; DelGiorno, K. E.
10.1101/2024.02.25.581948 — cancer biology — Posted on 2025-01-13
3343 Phylogenetic biome niche conservatism underlies the evolution of forest paleoendemic legume trees in tropical Africa
Ojeda Alayon, D.; Gorel, A.-P.; Dauby, G.; Cervantes Arango, S.; Pan, A. D.; Marcussen, T.; Vanden Abeele, S.; Boom, A.; Forest, F.; de la Estrella, M.; Hardy, O. J.
10.1101/2025.01.10.632308 — evolutionary biology — Posted on 2025-01-13
3345 Impacts of Habitat Transformation on Amphibian and Reptile Communities in a Heterogeneous Andean Landscape
Falcon-Espitia, N.; Rios-Orjuela, J. C.; Perez-Rojas, S.; Plazas-Cardona, D.; Arias-Escobar, A.
10.1101/2025.01.10.632384 — ecology — Posted on 2025-01-13
3349 Prolyl isomerase FKBP12 reduces axon growth and negatively regulates microtubule polymerization by inhibiting CRMP2A
Weissova, R.; Sabo, J.; Chafai, D. E.; Ziak, J.; Buran, P.; Bodakuntla, S.; Janke, C.; Lansky, Z.; Balastik, M.
10.1101/2025.01.13.632804 — neuroscience — Posted on 2025-01-13
3355 Title: Cell-autonomous and non-cell-autonomous effects of TRIM72 on ALS disease progression
Jia, Y.; Fan, D.; Zhang, X.; He, J.; Song, N.; Li, X.; Wang, W. X.; Hu, Y.; Li, Q.; Hu, Y.; Yin, C.; Zhao, P.; Jiang, X.; Piao, X.; Meng, D.; Cheng, H.; Chen, Z.; Huang, X.; Yu, P.; Qi, X.; Ren, J.; Luo, L.; Peng, L.; Guo, W.; Wang, T.; Gong, H.
10.1101/2025.01.09.632080 — neuroscience — Posted on 2025-01-13
3356 Selective Targeting of Pathogenic Tau Seeds via a Novel VHH
GUPTA, A.; Liu, R.; Keely, D.; Sunderman, V.; Tak, Y.; Kostantoulea, K.; Terpack, S.-J. E.; White, C. L.; Russ, W. P.; Rizo, J.; Louros, N.; Vaquer-Alicea, J.; Diamond, M. I.
10.1101/2025.01.13.632833 — neuroscience — Posted on 2025-01-13
3361 Cerebellar transcranial alternating current stimulation in the theta band facilitates extinction of learned fear responses
Thieme, A.; Spisak, Z.; Zeidan, P.; Klein, M.; Nio, E.; Ernst, T. M.; Diekmann, N.; Goericke, S.; Cheng, S.; Merz, C. J.; Yavari, F.; Nitsche, M.; Batsikadze, G.; Timmann, D.
10.1101/2025.01.13.632735 — neuroscience — Posted on 2025-01-13
3362 Deciphering Brain Organoids Heterogeneity by Identifying Key Quality Determinants
Kachkin, D.; Zagha, N.; Boerstler, T.; Furlanetto, F.; Nayebzade, N.; Zappia, L.; Boisvert, M.; Farrell, M.; Ploetz, S.; Regensburger, M.; Guenther, C.; Winkler, J.; Gupta, P.; Theis, F.; Karow, M.; Falk, S.; Winner, B.; Krach, F.
10.1101/2025.01.13.632763 — neuroscience — Posted on 2025-01-13
3364 Integrated Multi-Omics Analyses of Synaptosomes Revealed Synapse-Centered Novel Targets in Alzheimer's Disease
kumar, S.; Ramos, E.; Hidalgo, A.; Rodarte, D.; Sharma, B.; Torres, M. M.; Devara, D.; Gadad, S. S.
10.1101/2025.01.09.631584 — neuroscience — Posted on 2025-01-13
3365 Characterizing Oligodendrocyte-Lineage Cells and Myelination in the Basolateral Amygdala: Insights from a Novel Methodology in Postmortem Human Brain
Perlman, K.; Curto, E.; Barnett-Burns, S.; Davoli, M.-A.; Yerko, V.; Merza, R.; Papadakis, A. I.; Spatz, A.; Pryce, C. R.; Turecki, G.; Mechawar, N.
10.1101/2025.01.09.631560 — neuroscience — Posted on 2025-01-13
3369 Astrocyte and mitochondrial footprints in brain-derived extracellular vesicles predict tau pathology
Espourteille, J.; Barve, A.; Zufferey, V.; Leroux, E.; Perbet, R.; Bagard, S.; Caillierez, R.; Maurage, C. A.; Toni, N.; Buee, L.; Colin, M.; Richetin, K.
10.1101/2025.01.09.632249 — neuroscience — Posted on 2025-01-13
3370 Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice
Mackowiak, B.; Haggerty, D. L.; Lehner, T.; Lin, Y.-H.; Fu, Y.; Lu, H.; Pawlosky, R. J.; Ren, T.; Seo, W.; Feng, D.; Zhang, L.; Lovinger, D. M.; Gao, B.
10.1101/2025.01.09.632203 — neuroscience — Posted on 2025-01-13
3371 CO2-dependent opening of Connexin 43 hemichannels
Dospinsecu, V. M.; Mascarenhas, A.; Butler, J.; Nijjar, S.; de Oliveira Taborda, K.; Connors, S.; Huang, L.; Dale, N.
10.1101/2025.01.13.632711 — neuroscience — Posted on 2025-01-13
3372 Glucocerebrosidase Deficiency Dysregulates Human Astrocyte Lipid Metabolism
Tahanis, A.; Nguyen, T.; Oji, S.; Martinez de Kraatz, M.; Jayasi, J.; Anderson, M.; Krencik, R.
10.1101/2025.01.09.632210 — neuroscience — Posted on 2025-01-13
3376 MiRNA-501-3p and MiRNA-502-3p: A Promising Biomarker Panel for Alzheimer's Disease
Devara, D.; Sharma, B.; Goyal, G.; Rodarte, D.; Kulkarni, A.; Tinu, N.; Pai, A.; Kumar, S.
10.1101/2025.01.09.632227 — neuroscience — Posted on 2025-01-13
3379 Audiovisual gamma stimulation enhances hippocampal neurogenesis and neural circuit plasticity in aging mice
Trinchero, M.; Herrero, M.; Mugnaini, M.; Arredondo, A. A.; Benas, S.; Satorre, I.; Kropff, E.; Schinder, A.
10.1101/2025.01.13.632794 — neuroscience — Posted on 2025-01-13
3380 Neuron type-specific mRNA translation programs provide a gateway for memory consolidation.
Oliveira, M. M.; Mosto, O.; Carney, R.; Liu, W.; Makinde, E.; Lu, E.; Ruiz, K. S.; Carew, T.; Klann, E. M.
10.1101/2025.01.13.632784 — neuroscience — Posted on 2025-01-13
3381 Frontoparietal activity related to neuropsychological assessment of working memory
Jurva, A.; Singh, B.; Qian, H.; Wang, Z.; Jacobs, M.; Dhima, K.; Englot, D.; Williams Roberson, S.; Bick, S.; Constantinidis, C.
10.1101/2025.01.13.632797 — neuroscience — Posted on 2025-01-13
3383 The emergence of the fractal bronchial tree
Mederacke, M.; Yamauchi, K. A.; Doumpas, N.; Schaumann, L.; Sperl, J.; Weikert, T.; Dane, D. M.; Hsia, C. C. W.; Pradella, M.; Bremerich, J.; Vetter, R.; Iber, D.
10.1101/2025.01.13.632436 — developmental biology — Posted on 2025-01-13
3384 Ptpn14 Knockout Mice Reveal Critical Female-Specific Roles for the Hippo Pathway
McCrea, E. M.; Makrides, N.; Tabata, T.; Vogel, H.; Howitt, B.; Reineking, W.; Vilches-Moure, J. G.; Wang, M.; Zhang, X.; Attardi, L. D.
10.1101/2025.01.13.632464 — developmental biology — Posted on 2025-01-13
3387 Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
Chou, C.-C.; Vest, R.; Prado, M. A.; Wilson-Grady, J.; Paulo, J. A.; Shibuya, Y.; Moran-Losada, P.; Lee, T.-T.; Luo, J.; Gygi, S. P.; Kelly, J. W.; Finley, D.; Wernig, M.; Wyss-Coray, T.; Frydman, J.
10.1101/2023.03.27.534444 — cell biology — Posted on 2025-01-13
3393 Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory
Hoisington, Z. W.; Gangal, H.; Phamluong, K.; Shukla, C.; Ehinger, Y.; Moffat, J. J.; Homanics, G. E.; Wang, J.; Ron, D.
10.1101/2024.06.13.597459 — neuroscience — Posted on 2025-01-13
3395 Chronic RNA G-quadruplex Accumulation in Aging and Alzheimer's Disease
Kallweit, L.; Saternos, H.; Hamlett, E. D.; Gilmore, A.; Granholm, A.-C.; Horowitz, S.
10.1101/2023.10.02.560545 — neuroscience — Posted on 2025-01-13
3396 Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain: replication and extension with 7 Tesla fMRI
Zhang, J.; Chen, D.; Deming, P.; Srirangarajan, T.; Theriault, J.; Kragel, P. A.; Hartley, L.; Lee, K. M.; McVeigh, K.; Wager, T.; Wald, L. L.; Satpute, A. B.; Quigley, K. S.; Whitfield-Gabrieli, S.; Barrett, L. F.; Bianciardi, M.
10.1101/2023.07.20.548178 — neuroscience — Posted on 2025-01-13
3401 Identification of a BACH1 lung cancer signature: A novel tool for understanding BACH1 biology and identifying new inhibitors.
Klenja-Skudrinja, D.; Walker, D.; Ali, K. X.; Higgins, M.; Patel, A. A.; Raj, D.; Creelman, A.; McDowall, C.; Wenta, T.; Larsson, E.; Wiel, C.; Sayin, V. I.; de la Vega, L.
10.1101/2025.01.10.632407 — cancer biology — Posted on 2025-01-13
3402 Biomimetic hydrogel platform reveals active force transduction from retinal pigment epithelium to photoreceptors
Korpela, S.; Kauppila, M.; Karema-Jokinen, V.; Sukki, L.; Kallio, P.; Skottman, H.; Nymark, S.; Ihalainen, T. O.
10.1101/2025.01.09.632113 — biophysics — Posted on 2025-01-13
3405 Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome
Draczkowski, P.; Chen, S.-N.; Chen, T.; Wang, Y.-S.; Huang, J. Y. C.; Tsai, M.-C.; Lin, S.-Y.; Viner, R.; Chang, Y.-C.; Wu, K.-P.; Hsu, S.-T. D.
10.1101/2025.01.13.632666 — biochemistry — Posted on 2025-01-13
3406 Selection and characterization of DNA aptamers targeting the surface borrelial protein CspZ with high-throughput cross-over SELEX
Guerin, M.; Vandevenne, M.; Matagne, A.; Aucher, W.; Verdon, J.; Paoli, E.; Ducrotoy, J.; Octave, S.; Avalle, B.; Maffucci, I.; Padiolleau, S.
10.1101/2025.01.13.632687 — biochemistry — Posted on 2025-01-13
3419 The transsulfuration pathway suppresses the embryonic lethalphenotype of glutathione reductase mutants in Caenorhabditis elegans
Valenzuela-Villatoro, M.; Guerrero-Gomez, D.; Gomez-Orte, E.; Cheng, Q.; Zheleva, A.; Mora-Lorca, J. A.; Petrovic, D.; O'Neil, N. J.; Ceron, J.; Hatakeyama, A.; Onami, S.; Filipovic, M.; Arner, E. S.; Cabello, J.; Miranda-Vizuete, A.
10.1101/2025.01.09.632117 — genetics — Posted on 2025-01-13
3420 Determining off-target effects of splice-switching antisense oligonucleotides using short read RNAseq in neuronally differentiated human induced pluripotent stem cells
Kuijper, E. C.; van der Graaf, L.; Pepers, B. A.; Ramos, M. G.; Korhorn, S.; Toonen, L. J. A.; Cats, D.; Buijsen, R. A. M.; Mina, E.; Mei, H.; van Roon-Mom, W. M. C.
10.1101/2025.01.09.631923 — genetics — Posted on 2025-01-13
3423 Chromosomal inversions mediated by tandem insertions of transposable elements
Araya, R. A.; Reinar, W. B.; Torresen, O. K.; Goubert, C.; Daughton, T. J.; Hoff, S. N. K.; Baalsrud, H. T.; Brieuc, M. S. O.; Komisarczuk, A.; Jentoft, S.; Cerca, J.; Jakobsen, K. S.
10.1101/2025.01.09.631634 — evolutionary biology — Posted on 2025-01-13
3424 Threat reduction must be coupled with targeted recovery programmes to conserve global bird diversity
Stewart, K.; Venditti, C.; Carmona, C. P.; Baker, J.; Clements, C.; Tobias, J. A.; Gonzalez-Suarez, M.
10.1101/2025.01.09.632120 — ecology — Posted on 2025-01-13
3427 Cervicovaginal microbial features predict Chlamydia trachomatis spread to the upper genital tract of infected women
Jeong, S.; Tollison, T. S.; Brochu, H.; Chou, H.; Huntress, I.; Yount, K. S.; Zheng, X.; Darville, T.; O'Connell, C. M.; Peng, X.
10.1101/2024.11.26.625070 — microbiology — Posted on 2025-01-13
3428 CD20+ natural killer cells are polyfunctional, memory-like cells that are enriched in inflammatory disorders
Albayrak, O.; Tiryaki, E.; Akkaya, N.; Kizilirmak, A. B.; Doran, T.; Gokmenoglu, G.; Yuksel, M.; Ulukan, B.; Uzulmez, M.; Baytekin, I.; Soylu, K.; Esendagli, G.; Meinl, I.; Koseoglu, M.; Yuksel, B.; Erus, S.; Arikan, C.; Vural, S.; Zeybel, M.; Soysal, A.; Meinl, E.; Vural, A.
10.1101/2025.01.09.632131 — immunology — Posted on 2025-01-13
3429 Palmitate-induced mitochondrial damage restricts histone acetylation in CD8+ T cells to impair anti-tumor immunity.
Tiberti, S.; Romeo, M.; Lauson, C. B. N.; Sheraj, I.; Catozzi, C.; Noberini, R.; Olivari, D.; Dallavilla, T.; Galie, S.; Ballerini, M.; Loffreda, A.; Schaefer, M. H.; Bonaldi, T.; Nezi, L.; Sdelci, S.; Manzo, T.
10.1101/2025.01.09.631811 — immunology — Posted on 2025-01-13
3430 Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses Neuroinflammation
Jank, L.; Singh, S. S.; Lee, J.; Dhukhwa, A.; Siavoshi, F.; Joshi, D.; Minney, V.; Gupta, K.; Ghimire, S.; Deme, P.; Schoeps, V. A.; Soman, K.; Ladakis, D.; Smith, M.; Borkowski, K.; Newman, J.; Baranzini, S. E.; Waubant, E. L.; Fitzgerald, K. C.; Mangalam, A. K.; Haughey, N.; Kornberg, M. D.; Chamling, X.; Calabresi, P. A.; Bhargava, P.
10.1101/2024.10.27.620437 — neuroscience — Posted on 2025-01-13
3433 KaMLs for Predicting Protein pKa Values and Ionization States: Are Trees All You Need?
Shen, M.; Kortzak, D.; Ambrozak, S.; Bhatnagar, S.; Buchanan, I.; Liu, R.; Shen, J.
10.1101/2024.11.09.622800 — biophysics — Posted on 2025-01-13
3437 Mobile Integrons Encode Phage Defense Systems
Kieffer, N.; Hipolito, A.; Ortiz-Miravalles, L.; Blanco, P.; Delobelle, T.; Vizuete, P.; Ojeda, F. M.; Jove, T.; Jurenas, D.; Garcia-Quintanilla, M.; Carvalho, A.; Domingo-Calap, P.; Escudero, J. A.
10.1101/2024.07.02.601719 — microbiology — Posted on 2025-01-13
3438 Two long-axis dimensions of hippocampal cortical integration support memory function across the adult lifespan
Nordin, K.; Pedersen, R.; Falahati, F.; Johansson, J.; Grill, F.; Andersson, M.; Korkki, S. M.; Backman, L.; Zalesky, A.; Rieckmann, A.; Nyberg, L.; Salami, A.
10.1101/2023.03.24.534115 — neuroscience — Posted on 2025-01-13
3439 12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice
Kaylan, K. B.; Nargis, T.; Figatner, K.; Wang, J. E.; Pratuangtham, S.; Chakraborty, A.; Casimiro, I.; Nadler, J. L.; Boxer, M. B.; Maloney, D. J.; Anderson, R. M.; Mirmira, R.; Tersey, S. A.
10.1101/2025.01.10.632274 — physiology — Posted on 2025-01-13
3442 Viscoelastic HyA Hydrogel Promotes Recovery of Muscle Quality and Vascularization in a Murine Model of Delayed Rotator Cuff Repair
Pfaff, M. R.; Wague, A.; Davies, M.; Killaars, A. R.; Ning, D.; Garcia, S.; Nguyen, A.; Nuthalapati, P.; Liu, M.; Liu, X.; Feeley, B. T.; Healy, K. E.
10.1101/2025.01.08.632047 — bioengineering — Posted on 2025-01-13
3443 Genetic and materials engineering to enhance inducible gene expression in lactobacilli
Blanch-Asensio, M.; Tadimarri, V. S.; Martinez, R. P.; Dahiya, G. S.; Lale, R.; Sankaran, S.
10.1101/2025.01.10.632477 — bioengineering — Posted on 2025-01-13
3444 Genomic exaptation and regulatory landscape shifts as key mechanisms enabling flatworm terrestrialization
Benitez-Alvarez, L.; Garcia-Vernet, R.; Eleftheriadi, K.; Vargas-Chavez, C.; Escudero, N.; Salces-Ortiz, J.; Rojo, I.; Fernandez-Alvarez, F. A.; Chiva, C.; Sabido, E.; Mateos, E.; Carbayo, F.; Fernandez, R.
10.1101/2025.01.09.632089 — evolutionary biology — Posted on 2025-01-13
3445 The developmental environment mediates adult seminal proteome allocation in male Drosophila melanogaster
von Hellfeld, R.; Konietzny, R.; Charles, P. D.; Kessler, B. M.; Wigby, S.; Sepil, I.; Morimoto, J.
10.1101/2025.01.09.632097 — evolutionary biology — Posted on 2025-01-13
3446 Tissue imprinting defines functional mosaic of dermal macrophages
Lohrmann, F.; Sankowski, R.; Schwer, S.; Neuber, J.; P Vlachou, E. P.; Westermann, F.; Troesch, E.; Kolter, J.; Kathrin Loesslein, A.; Das Mahapatra, K.; Doering, C.-L.; Ghanem, N.; Kohnert, E.; Heselich, A.; Staszewski, O.; Monaco, G.; Mueller, A.; Eyerich, K.; Zeiser, R.; Prinz, M.; Becher, B.; Zaugg, J.; Kreutz, C.; Sagar, ; Henneke, P.
10.1101/2025.01.09.631670 — immunology — Posted on 2025-01-13
3447 c-Myc inhibits macrophage antimycobacterial response in Mycobacterium tuberculosis infection
Sarti, E.; Dolle, C.; Wolfensberger, R.; Kusejko, K.; Russenberger, D.; Bredl, S.; Speck, R. F.; Greter, M.; Rueschoff, J. H.; Boeck, L.; Mai, D.; Diercks, A. H.; Sander, P.; Olson, G. S.; Nemeth, J.
10.1101/2025.01.09.632095 — immunology — Posted on 2025-01-13
3449 A single pathogen-secreted protein reprograms plants for drought resilience
Subieta, K.; Weber, L.; Luebbers, J.-N.; Wiesotzki, K.; Pierdzig, L.; Thurow, C.; Schmitz, J.; Lipka, U.; Heimel, K.; Schmitt, K.; Thuermer, A.; Poehlein, A.; Daniel, R.; de Vries, J.; Valerius, O.; Braus, G. H.; Polle, A.; Gatz, C.; Teichmann, T.; Lipka, V.
10.1101/2025.01.09.632073 — plant biology — Posted on 2025-01-13
3450 Integrating flowering and stress responses in Arabidopsis through KH-domain genes
Rodriguez Cazorla, E.; Ripoll, J.-J.; Candela, H.; Aranda-Martinez, A.; Zavala-Gonzalez, E.; Martinez-Laborda, A.; Vera, A.
10.1101/2025.01.09.631668 — plant biology — Posted on 2025-01-13
3451 Tissular glucocorticoid reactivating enzyme 11beta-HSD1 drives pathogenic myofibroblast differentiation in chronic kidney disease
Arnoux, G.; Legouis, D.; Tihy, M.; Yvon, R.; Liaudet, N.; Moser, S.; Poinot, H.; SASSI, A.; Lempke, O.; Fernandez, M.; Monnay, I.; Chassot, A.; Bourquin, C.; Moll, S.; Somm, E.; Rutkowski, J. M.; Wenger, R. H.; Naesens, M.; Odermatt, A.; Nlandu Khodo, S.; Pommier, A.; Feraille, E.
10.1101/2025.01.09.631985 — physiology — Posted on 2025-01-13
3458 Linking Molecular Tension and Cellular Tractions: A Multiscale Approach to Focal Adhesion Mechanics
Aytekin, S.; Kimps, L.; Coucke, Q.; Linhares, D.; Deodhar, S.; Cardinaels, R.; Condor, M.; Barrasa-Fano, J.; Van Oosterwyck, H.; Rocha, S.
10.1101/2025.01.09.632081 — biophysics — Posted on 2025-01-13
3460 Pillar arrays as tunable interfacial barriers for microphysiological systems
Goswami, I.; Kim, Y.; Neiman, G.; Siemons, B.; Velazquez, J. I.; Yazgan, K.; Ng, T.; Healy, K.
10.1101/2025.01.08.632020 — bioengineering — Posted on 2025-01-13
3465 The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain
Heyza, J. R.; Mikhova, M.; Perez, G. I.; Broadbent, D. G.; Schmidt, J. C.
10.1101/2025.01.10.632395 — cell biology — Posted on 2025-01-13
3467 T cells are necessary for development of PCOS reproductive symptoms in a letrozole-induced mouse model of PCOS
Ujagar, N.; Velez, L.; De Robles, G.; Nguyen, C.; Wiggins, K.; Kim, J.; Naidu, N.; Angulo, J. A.; Kaufmann, A. S.; Thackray, V. G.; Banaszewska, B.; Wysocka, E.; Duleba, A.; Seldin, M. M.; Nicholas, D. A.
10.1101/2025.01.08.631835 — immunology — Posted on 2025-01-13
3469 A Technical Evaluation of Plasma Proteomics Technologies
Beimers, W. F.; Overmyer, K. A.; Sinitcyn, P.; Lancaster, N. M.; Coon, J. J.
10.1101/2025.01.08.632035 — systems biology — Posted on 2025-01-13
3472 Markers of mitochondrial function and oxidative metabolism in female skeletal muscle do not display intrinsic circadian regulation
Fitzgerald, L. S.; Spurrier, C. S. R.; Lau, N.; Melamed, M.; Burnett, L. A.; Meyer, G. A.; Gui, C.; Hevener, A. L.; Sanford, J. A.; Schenk, S.
10.1101/2025.01.08.631231 — physiology — Posted on 2025-01-13
3474 PixlMap: A generalisable pixel classifier for cellular phenotyping in multiplex immunofluorescence images
Pennie, R. L.; Mason, D.; Rakovic, K.; Ballantyne, F.; Powley, I. R.; Georgakopoulou, A.; Bird, T. G.; Officer-Jones, L.; Le Quesne, J.
10.1101/2025.01.08.632002 — pathology — Posted on 2025-01-13
3475 PRPS activity tunes redox homeostasis in Myc-driven lymphoma
MacMillan, A. C.; Karki, B.; Yang, J.; Gertz, K. R.; Zumwalde, S.; Czyzyk-Krzeska, M. F.; Meller, J.; Cunningham, J. T.
10.1101/2025.01.08.632009 — cancer biology — Posted on 2025-01-13
3476 Three-dimensional patient-derived models of glioblastoma retain intra-tumoral heterogeneity
Moore, Z.; Storey, C.; Brown, D. V.; Valkovic, A.; Spiteri, M.; Pignatelli, J. F.; Oliver, S. J.; Fakhri, A.; Drummond, K. J.; Malinowski, S.; Ligon, K. L.; Sieber, O. M.; Whittle, J. R.; Freytag, S.; Best, S. A.
10.1101/2025.01.08.632025 — cancer biology — Posted on 2025-01-13
3477 AR-V7 condensates drive androgen-independent transcription in castration resistant prostate cancer
Massah, S.; Pinette, N.; Foo, J.; Datta, S.; Guo, M.; Bell, R.; Haegert, A.; Terrado, M.; Volik, S.; Le Bihan, S.; Tekoglu, E.; Bui, J. M.; Lack, N. A.; Gleave, M. E.; Lallous, N.; Rhie, S. K.; Collins, C. C.; Gsponer, J.
10.1101/2025.01.08.631986 — cancer biology — Posted on 2025-01-13
3479 Metapipeline-DNA: A Comprehensive Germline & Somatic Genomics Nextflow Pipeline
Patel, Y.; Zhu, C.; Yamaguchi, T. N.; Wang, N.; Wiltsie, N.; Gonzalez, A.; Winata, H.; Zeltser, N.; Pan, Y.; Mootor, M. F. E.; Sanders, T.; Kandoth, C.; Fitz-Gibbon, S. T.; Livingstone, J.; Liu, L. Y.; Carlin, B.; Holmes, A.; Oh, J.; Sahrmann, J.; Tao, S.; Eng, S.; Hugh-White, R.; Pashminehazar, K.; Park, A.; Beshlikyan, A.; Jordan, M.; Wu, S.; Tian, M.; Arbet, J.; Neilsen, B.; Bugh, Y. Z.; Kim, G.; Salmingo, J.; Zhang, W.; Haas, R.; Anand, A.; Hwang, E.; Neiman-Golden, A.; Steinberg, P.; Zhao, W.; Anand, P.; Tsai, B. L.; Boutros, P. C.
10.1101/2024.09.04.611267 — bioinformatics — Posted on 2025-01-13
3480 The Plantae Visualization Platform: a comprehensive web-based tool for the integration, visualization, and analysis of omic data across plant and related species
Santiago, A.; Orduna, L.; Fernandez, J. D.; Vidal, A.; de Martin-Agirre, I.; Lison, P.; Vidal, E.; Navarro-Paya, D.; Matus, J. T.
10.1101/2024.12.19.629382 — bioinformatics — Posted on 2025-01-13
3482 Defining the limits of plant chemical space: challenges and estimations
Hart, C. E.; Gadiya, Y.; Kind, T.; Krettler, C. A.; Gaetz, M.; Misra, B. B.; Healey, D.; Allen, A.; Colluru, V.; Domingo-Fernandez, D.
10.1101/2025.01.08.631938 — bioinformatics — Posted on 2025-01-13
3484 Learning a CoNCISE language for small-molecule binding
Erden, M.; Devkota, K.; Varghese, L.; Cowen, L.; Singh, R.
10.1101/2025.01.08.632039 — bioinformatics — Posted on 2025-01-13
3486 Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function
Gholamalamdari, O.; van Schaik, T.; Wang, Y.; Kumar, P.; Zhang, L.; Zhang, Y.; Gonzalez, G. A. H.; Vouzas, A. E.; Zhao, P. A.; Gilbert, D. M.; Ma, J.; van Steensel, B.; Belmont, A. S.
10.1101/2024.04.23.590809 — genomics — Posted on 2025-01-13
3488 Rapid polygenic adaptation in a wild population of ash trees under a novel fungal epidemic
Metheringham, C. L.; Plumb, W.; Flynn, W.; Stocks, J.; Kelly, L.; Nemesio Gorriz, M.; Grieve, S.; Moat, J.; Lines, E.; Buggs, R.; Nichols, R. A.
10.1101/2022.08.01.502033 — evolutionary biology — Posted on 2025-01-13
3489 Quantifying food competition between two demersal fish species from spatiotemporal stomach content data
Lindmark, M.; Maioli, F.; Anderson, S. C.; Gogina, M.; Bartolino, V.; Skold, M.; Ohlsson, M.; Eklof, A.; Casini, M.
10.1101/2024.04.22.590538 — ecology — Posted on 2025-01-13
3492 A comparative analysis of planarian regeneration specificity reveals tissue polarity contributions of the axial cWnt signalling gradient.
Cleland, J. P.; Vu, H. T.- K.; Dickmann, J. E. M.; Rozanski, A.; Werner, S.; Schuhmann, A.; Shevchenko, A.; Rink, J. C.
10.1101/2024.12.01.626254 — developmental biology — Posted on 2025-01-13
3494 mTOR signaling governs the formation of epithelial apical projection via S6K1-RhoA and aPKC-Lgl2 axes
Sen, S.; Ghosh, P.; Mukherjee, S.; Prabhu, S.; Khurana, G.; Pinto, C. S.; Gupta, K.; Venkatramani, R.; Sonawane, M.
10.1101/2024.12.08.627438 — cell biology — Posted on 2025-01-13
3497 Ecosystems Oxygen Deficiency and Selection of Antimicrobial Resistance Genes in a One Health Perspective
Ortiz-Miravalles, L.; Prieto, A.; Kieffer, N.; Vergara, E.; Canton, R.; San Millan, A.; Baquero, F.; Hipolito, A.; Escudero, J. A.
10.1101/2024.05.17.594675 — microbiology — Posted on 2025-01-13
3498 A cationic liposome-formulated Toll Like Receptor (TLR)7/8 agonist enhances the efficacy of a vaccine against fentanyl toxicity
Hamid, F. A.; Le, N.-M. N.; Song, D.; Amin, H.; Hicks, L.; Bird, S.; Siram, K.; Hoppe, B.; Demeler, B.; Evans, J. T.; Burkhart, D.; Pravetoni, M.
10.1101/2025.01.08.631964 — immunology — Posted on 2025-01-13
3500 Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease
Binns, T. S.; Köhler, R. M.; Vanhoecke, J.; Chikermane, M.; Gerster, M.; Merk, T.; Pellegrini, F.; Busch, J. L.; Habets, J. G. V.; Cavallo, A.; Beyer, J.-C.; Al-Fatly, B.; Li, N.; Horn, A.; Krause, P.; Faust, K.; Schneider, G.-H.; Haufe, S.; Kühn, A. A.; Neumann, W.-J.
10.1101/2024.04.14.586969 — neuroscience — Posted on 2025-01-13
3504 Rapid evolution of Wolbachia in cherry fruit flies
Bruzzese, D. J.; Schuler, H.; Yee, W. L.; Holzschuh, A.; Feder, J. L.
10.1101/2025.01.13.632697 — evolutionary biology — Posted on 2025-01-13
3505 Multi-omics analysis of keratinocytes reveals dermokine-dependent regulation of cell-cell adhesion via p120
Canbay, V.; Wuestemann, T.; Tian, W.; Beyer, T. A.; Elbaek, C. R.; Stumpe, M.; Restivo, G.; Christiansen, C.; Herranz, A. M.; Mailand, S.; Hafner, J.; Damgaard, R. B.; Goletz, S.; Dengjel, J.; auf dem Keller, U.; Francavilla, C.
10.1101/2025.01.10.632346 — cell biology — Posted on 2025-01-13
3508 The microbiota of fresh unfermented date palm sap: a culturomics and metagenomics investigation.
Djemal, S.; Gdoura, M.; Mathlouthi, N. E. H.; Gdoura, R.; Cassagne, C.; Oumarou Hama, H.
10.1101/2025.01.10.632404 — microbiology — Posted on 2025-01-13
3509 Inhibitory effect of Dolosigranulum pigrum and Corynebacterium pseudodiphtheriticum on pneumococcal in vitro growth
Cisneros, M.; Blanco-Fuertes, M.; Lluansi, A.; Brotons, P.; Henares, D.; Perez-Argüello, A.; Gonzalez-Comino, G.; Ciruela, P.; Mira, A.; Munoz-Almagro, C.
10.1101/2025.01.10.632320 — microbiology — Posted on 2025-01-13
3512 Immunogenomic profiling of circulating T cells in pediatric cancer patients during standard-of-care
Nabbi, A.; Jiang, Y.; Espin Garcia, O.; Mohanraj, S.; Pedersen, S.; Regala, J.; Vernau, L.; Perazzelli, J.; Barrett, D. M.; Pugh, T. J.
10.1101/2025.01.10.632468 — cancer biology — Posted on 2025-01-13
3514 Patterns of population structure and genetic variation within the Saudi Arabian population
Malomane, D. K.; Williams, M. P.; Huber, C. D.; Mangul, S.; Abedalthagafi, M.; Chiang, C. C. W.
10.1101/2025.01.10.632500 — evolutionary biology — Posted on 2025-01-13
3518 The PST repeat region of MDC1 is a tunable multivalent chromatin tethering domain
Heyza, J. R.; Mikhova, M.; Perez, G. I.; Broadbent, D. G.; Schmidt, J. C.
10.1101/2025.01.10.632395 — cell biology — Posted on 2025-01-13
3519 Extracellular stiffness regulates site-specific lung development
Liao, Z.; Lv, J.; Wang, D.; Chen, X.; Zhao, J.; Xu, T.; Meng, H.; Liu, H.
10.1101/2025.01.12.632508 — cell biology — Posted on 2025-01-13
3520 Systematic Identification of Microtubule Inner Proteins Reveals JPT2 as a Key Regulator of Lumen Microenvironment and Drug Sensitivity
Shao, J.; Zhang, R.; Wu, P.; Xu, H.; Zhou, Z.; Gu, L.; Wang, L.; Ren, J.; Huang, X.; Xie, Q.; Wang, Y.; Ji, W.; Feng, W.; Liang, X.; Meng, W.
10.1101/2025.01.12.632577 — cell biology — Posted on 2025-01-13
3522 Systematic characterization of zinc in a series of breast cancer cell lines reveals significant changes in zinc homeostasis
Woyciehowsky, M.; Larson, P.; Stephan, A. R.; Dandridge, S. L.; Idonije, D.; Berg, K. A.; Lanthier, A.; Araiza Acuna, S.; Stites, S. W.; Gebhardt, W. J.; Holtzen, S. E.; Rakshit, A.; Palmer, A. E.
10.1101/2025.01.11.632547 — cell biology — Posted on 2025-01-13
3523 Catalytic degradation of circulating targets with FcRn-mediated cycling LYTACs
Kougentakis, C.; Shurtleff, M. J.; Lieser, R. M.; Chen, T.; Collins, C. L.; Johnson, I. E.; Gu, S.; Akama, K. T.; Doran, K. H.; Fung, C. K.; Hildebrandt, D. H.; Khaleghi, R.; Li, D.; Rank, S.; Tran, T.-T.; Yau, R.; Holly, R. W.; Langsdorf, C.; Lindhout, D. A.; McWhirter, S. M.; Iwig, J. S.; Lewis, J. G.; Staben, S. T.; Turtle, E. D.; Lind, N. A.
10.1101/2025.01.12.632472 — cell biology — Posted on 2025-01-13
3524 Specialized Molecular Pathways Drive the Formation of Light-Scattering Assemblies in Leucophores
Barzilay, Y.; Eyal, Z.; Noy, Y.; Varsano, N.; Olender, T.; Bera, S.; Lerer-Goldshtein, T.; Kedmi, M.; Porat, Z.; Pinkas, I.; Levin-Zaidman, S.; Dezorella, N.; Gur, D.
10.1101/2025.01.12.632588 — cell biology — Posted on 2025-01-13
3527 Euprymna berryi as a comparative model host for Vibrio fischeri light organ symbiosis
Imes, A. M.; Pavelsky, M.; Badal, K.; Kamp, D. L.; Briseno, J. L.; Sakmar, T.; Vogt, M. A.; Nyholm, S. V.; Heath-Heckman, E.; Grasse, B.; Septer, A. N.; Mandel, M. J.
10.1101/2025.01.10.632448 — microbiology — Posted on 2025-01-13
3529 BASTA, a simple whole blood assay for measuring beta-cell antigen specific CD4+ T-cell responses in type 1 diabetes
Lacorcia, M.; Bhattacharjee, P.; Foster, A.; Hardy, M. Y.; Tye-Din, J.; Karas, J.; Wentworth, J.; Cameron, F.; Mannering, S. I.
10.1101/2025.01.08.631617 — immunology — Posted on 2025-01-13
3531 Loss of Effort in Chronic Low-Back Pain Patients: Motivational Anhedonia in Chronic Pain
Alldritt, S.; Jammoul, M.; Makary, M.; Becker, S.; Maeng, D.; Keane, B.; Zald, D.; Geha, P.
10.1101/2025.01.09.632293 — neuroscience — Posted on 2025-01-13
3532 Longitudinal Stability of Mood-Related Resting-State Networks in Youth with Symptomatic Bipolar-I/II Disorder
Hafeman, D. M.; Feldman, J.; Mak, J.; Merranko, J.; Gratton, C.; Phillips, M. L.; Birmaher, B.
10.1101/2025.01.10.630933 — neuroscience — Posted on 2025-01-13
3533 Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors
RAMPERSAUD, R.; Suneson, K.; Wu, G.; Lindqvist, D.; Ho, T.; Myerhoff, D.; Reus, V.; Irwin, M.; Mellon, S.; Wolkowitz, O.; Brundin, L.
10.1101/2025.01.11.632543 — neuroscience — Posted on 2025-01-13
3535 A novel citizen science-based wildlife monitoring and management tool for oil palm plantations
Maharani, N.; Nardiyono, N.; Swayanuar, P.; Munthe, C. R.; NiMatullah, S.; Sueif, S.; Zaini, S.; Supriatna, J.; Kusrini, M.; Dennis, R.; van Balen, B.; van Strien, A.; Meijaard, E.
10.1101/2025.01.12.632638 — scientific communication and education — Posted on 2025-01-13
3539 Plasma membrane mediated GLUT10 mitochondrial targeting regulates intracellular ascorbic acid homeostasis
Jose, A. C.; Syu, Y.-W.; Lai, H.-W.; Tsai, M.-Y.; Jiang, Y.-F.; Hsu, S.-C.; Lin, P.-Y.; Huang, W.-C.; Chu, W.-C.; Fu, C.-Y.; Lee, Y.-C.
10.1101/2025.01.09.632083 — cell biology — Posted on 2025-01-13
3542 Identification of a novel GREMLIN1 uptake pathway in epithelial cells that requires BMP binding
Brazil, D.; Gao, Z.; Gao, Y.; Dutton, L.; Todd, G.; Gipson, G.; Brown, C.; Kerr, E. M.; Daly, C.; Plouffe, B.; Dunne, P.
10.1101/2025.01.09.632157 — cell biology — Posted on 2025-01-13
3543 Altered RNA-processing provides a mechanistic framework delineating human sex reversal associated with pathogenic variants in the RNA-helicase DHX37
Elzaiat, M.; Talouarn, E.; Wankanit, S.; Schlick, L.; Eozenou, C.; Bignon-Topalovic, J.; Kornobis, E.; Commere, P.-H.; Baum, C.; Seffer, V.; McElreavey, K.; Bashamboo, A.
10.1101/2025.01.10.632330 — cell biology — Posted on 2025-01-13
3544 Piezo1 activation increases the release of therapeutic extracellular vesicles after mechanical stimulation in bioreactors
Andrade, A. C.; Le Goas, O.; Lemieux, S.; Grangier, A.; Nicolai, A.; Guerrera, C.; Ribes, C.; Suply, E.; Volatron, J.; Gazeau, F.; Silva, A. K. A.
10.1101/2025.01.09.632205 — cell biology — Posted on 2025-01-13
3550 Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals to navigate soil
Kulich, I.; Vladimirtsev, D.; Randuch, M.; Gao, S.; Citterico, M.; Konrad, K.; Nagel, G.; Wrzaczek, M.; Friml, J.
10.1101/2025.01.07.631646 — plant biology — Posted on 2025-01-13
3556 Sex chromosomes and chromosomal rearrangements are key to behavioural sexual isolation in Jaera albifrons marine isopods
Ribardiere, A.; Daguin-Thiebaut, C.; Coudret, J.; Le Corguille, G.; Avia, K.; Houbin, C.; Loisel, S.; Gagnaire, P.-A.; Broquet, T.
10.1101/2025.01.08.631900 — evolutionary biology — Posted on 2025-01-13
3560 Corticosteroid resistance is predetermined by early immune response dynamics at acute Graft Versus Host disease onset
Le Grand, S.; Marie, Y.; Bouteiller, D.; Robert, E.; Peffault de Latour, R.; Socie, G.; Vallet, N.; Michonneau, D.
10.1101/2025.01.12.632608 — molecular biology — Posted on 2025-01-12
3569 Single-nuclei transcriptomics revealed auxin-driven mechanisms of wood plasticity and severe drought tolerance in poplar
Gomez-Soto, D.; Pereira, W. J.; Piedrabuena-Diaz, A.; Dervinis, C.; Kirst, M.; Allona, I.; Perales, M.; Conde, D.
10.1101/2025.01.08.631930 — plant biology — Posted on 2025-01-13
3576 Sparse Sequencing permits accurate and efficient quantification of genome-wide cytosine modification levels
Loo, C. E.; Fowler, J. M.; Krapp, C.; Zhu, R.; Zhu, W.; Bartolomei, M.; Zhou, W.; Kohli, R. M.
10.1101/2025.01.08.631958 — genomics — Posted on 2025-01-12
3577 Genetic mapping in Collaborative Cross mouse strains identifies loci that affect initial sensitivity to cocaine
Schoenrock, S. A.; Gaines, C. H.; Kumar, P.; Khan, S. A.; Farrington, J.; Ferris, M. T.; Pardo-Manuel de Villena, F.; Valdar, W.; Bubier, J.; Tarantino, L. M.
10.1101/2025.01.12.629464 — genetics — Posted on 2025-01-12
3578 Pathogen and pest communities in food security crops across climate gradients: Anticipating future challenges in the Great Lakes region of Africa
Mouafo-Tchinda, R.; Plex Sula, A.; Etherton, B. A.; Okonya, J.; Nakato, G. V.; Xing, Y.; Robledo Buritica, J.; Adhikari, A.; Blomme, G.; Kantungeko, D.; Nduwayezu, A.; Kreuze, J. F.; Kroschel, J.; Legg, J.; Garrett, K. A.
10.1101/2025.01.08.631994 — ecology — Posted on 2025-01-13
3579 Fibroblast contractility drives network reorganization and epithelial proliferation in intestinal polyposis
Li, M.-L.; Wang, Y.; Figetakis, M.; Gonzalez, D.; Jin, J.; McDonald, E. S.; Ameen, N. A.; Sumigray, K.
10.1101/2025.01.08.632004 — cell biology — Posted on 2025-01-13
3581 Mitochondria transported by Kinesin 3 prevent localized calcium spiking to inhibit caspase-dependent specialized cell death
Sharmin, R.; Elkhalil, A.; Pena, S.; Gaddipati, P.; Clark, G.; Shah, P. K.; Pellegrino, M. W.; Shaham, S.; Ghose, P.
10.1101/2025.01.08.631976 — cell biology — Posted on 2025-01-13
3584 SELECTION OF ANTI-NUCLEAR ANTIGEN (ANA) REACTIVE B CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS.
Atisha-Fregoso, Y.; Meng, W.; Rosenfeld, A.; Liu, F.; Feltman, S.; Aranow, C.; Mackay, M.; Terestchenko, C.; Dunn, M.; Scharff, M.; Prak, E. L.; Diamond, B.
10.1101/2025.01.08.631945 — immunology — Posted on 2025-01-13
3585 Dynamic Transcriptomic Remodeling in Human Neural Progenitor Cells Reveals Mechanisms for Vision Preservation in Retinitis Pigmentosa Model
Shahin, S.; Bell, S.; Lu, B.; Banerjee, S.; Swarup, V.; Xu, H.; Chetsawang, J.; Ramirez, S.; Alfaro, J. S.; Laperle, A.; Svendsen, S.; Svendsen, C. N.; Wang, S.
10.1101/2025.01.06.631620 — neuroscience — Posted on 2025-01-12
3588 A novel RyR2-selective stabilizer prevents stress-induced ventricular tachycardia without compromising cardiac function
Kurebayashi, N.; Kodama, M.; Murayama, T.; Konishi, M.; Sugihara, M.; Inoue, H.; Ishida, R.; Ishii, K.; Mori, S.; Endo, Y.; Zeng, X.; Inoue, Y. U.; Inoue, T.; Noguchi, S.; Nishio, H.; Yokoyama, U.; Kurokawa, J.; Kagechika, H.; Sakurai, T.
10.1101/2024.11.26.625386 — pharmacology and toxicology — Posted on 2025-01-12
3590 Unsupervised reference-free inference reveals unrecognized regulated transcriptomic complexity in human single cells
Dehghannasiri, R.; Henderson, G.; Bierman, R.; Chaung, K.; Baharav, T. Z.; Wang, P. L.; Salzman, J.
10.1101/2022.12.06.519414 — bioinformatics — Posted on 2025-01-12
3591 Adipocyte Aldosterone in Obstructive Sleep Apnea
Dong, Y.; Bock, J. M.; Karim, S.; Singh, P.; Somers, V. K.
10.1101/2025.01.07.631499 — molecular biology — Posted on 2025-01-12
3593 APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
Naguib, S. A.; Lopez-Lee, C.; Torres, E. R.; Lee, S.-I.; Zhu, J.; Zhu, D.; Ye, P.; Norman, K.; Zhao, M.; Wong, M. Y.; Ambaw, Y.; Castaneda, R.; Wang, W.; Patel, T.; Bhagwat, M.; Norinsky, R.; Mok, S.-A.; Walther, T. C.; Farese, R. C.; Luo, W.; Sinha, S.; Wu, Z.; Fan, L.; Gong, S.; Gan, L.
10.1101/2024.04.25.591140 — neuroscience — Posted on 2025-01-12
3594 Vascular contribution to cognitive impairment in heart failure with preserved ejection fraction: TRPV4 and KLF2 as key mediators of neurovascular dysfunction in the ZSF1 model
Lambrichts, S. M. P.; van der Taelen, L.; Pastor, I.; Leenders, P.; Bitsch, N.; Majcher, D.; Hermes, D.; Simmonds, S. J.; van Herwijnen, M.; Kamps, R.; Weltjens, E.; Steinbusch, H. P.; Caiment, F.; Kutmon, M.; Jones, E. A. V.; van Oostenbrugge, R. J.; Foulquier, S.
10.1101/2025.01.08.631937 — neuroscience — Posted on 2025-01-12
3597 ACTIVITY IN HUMAN DORSAL RAPHE NUCLEUS SIGNALS CHANGES IN BEHAVIOURAL POLICY
Priestley, L.; Mahmoodi, A.; Reith, W.; Khalighinejad, N.; Rushworth, M. F.
10.1101/2025.01.08.632066 — neuroscience — Posted on 2025-01-12
3603 Sleep increases propagation speed of physiological brain pulsations
Elabasy, A.; Helakari, H.; Vayrynen, T.; Rajna, Z.; Huotari, N.; Raitamaa, L.; Isokoski, V.; Jarvela, M.; Kaakinen, M.; Piispala, J.; Kallio, M.; Korhonen, V.; Seppanen, T.; Kiviniemi, V.
10.1101/2025.01.09.632145 — neuroscience — Posted on 2025-01-12
3604 Image-based screens identify regulators of endogenous Dvl2 biomolecular condensates
Schubert, A.; Heigwer, F.; Voloshanenko, O.; Scheeder, C.; Kranz, D.; Miersch, T.; Schmitt, B.; Kuhse, M.; Ragaller, F.; Winkler, N.; Gimenes, D.; Ordonez-Rueda, D.; Schwarz, J.; Stein, F.; Jaeger, D.; Engel, U.; Boutros, M.
10.1101/2025.01.11.632522 — cell biology — Posted on 2025-01-12
3605 An expanded palette of bright and photostable organellar Ca2+ sensors
Moret, A.; Farrants, H.; Fan, R.; Zingg, K.; Gee, C. E.; Oertner, T. G.; Rangaraju, V.; Schreiter, E. R.; de Juan-Sanz, J.
10.1101/2025.01.10.632364 — cell biology — Posted on 2025-01-12
3607 Memory engram synapse 3D molecular architecture visualized by cryoCLEM-guided cryoET
Lovatt, C.; O'Sullivan, T. J.; Ortega-de San Luis, C.; Ryan, T. J.; Frank, R. A. W.
10.1101/2025.01.09.632151 — neuroscience — Posted on 2025-01-12
3608 Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution
Lodder, B.; Kamath, T.; Savenco, E.; Roring, B.; Siegel, M.; Chouinard, J.; Lee, S. J.; Zagoren, C.; Rosen, P. C.; Tian, L.; Adan, R.; Sabatini, B. L.
10.1101/2025.01.10.632162 — neuroscience — Posted on 2025-01-12
3609 Competing signaling pathways controls electrotaxis
Kulkarni, S.; Tebar, F.; Rentero, C.; Zhao, M.; Saez, P.
10.1101/2025.01.10.631288 — biophysics — Posted on 2025-01-12
3610 Giant KASH proteins and ribosomes synergistically establish cytoplasmic biophysical properties in vivo
Ding, X.; Hao, H.; Elnatan, D.; Alinaya, P. N.; Kalra, S.; Kaur, A.; Kumari, S. J.; Holt, L. J.; Luxton, G. G.; Starr, D. A.
10.1101/2025.01.10.632479 — biophysics — Posted on 2025-01-12
3612 Identification of critical factors of the replication stress response in human cells
Janssen, L. M. E.; Baltasar Perez, E.; Vaarting, C.; Mazouzi, A.; Raaben, M.; Brummelkamp, T. R.; Medema, R. H.; Raaijmakers, J.
10.1101/2025.01.12.632149 — cell biology — Posted on 2025-01-12
3614 Dietary protein source alters gut microbiota composition and function
Blakeley-Ruiz, J. A.; Bartlett, A.; McMillan, A. S.; Awan, A.; Vanhoy Walsh, M.; Meyerhoffer, A. K.; Vintila, S.; Maier, J. L.; Richie, T.; Theriot, C. M.; Kleiner, M.
10.1101/2024.04.04.588169 — microbiology — Posted on 2025-01-12
3619 Understanding the high-order network plasticity mechanisms of ultrasound neuromodulation
Gatica, M.; Atkinson-Clement, C.; Coronel-Oliveros, C.; Alkhawashki, M.; Mediano, P. A. M.; Tagliazucchi, E.; Rosas, F. E.; Kaiser, M.; Petri, G.
10.1101/2025.01.11.632528 — neuroscience — Posted on 2025-01-12
3620 Transgenic A53T mice have astrocytic α-synuclein aggregates in dopamine and striatal regions
Peat, C.; Prasad, A.; Finkelstein, D. I.; Sue, C.; Johnston, J.; Parish, C.; Thompson, L.; Kirik, D.; Halliday, G.
10.1101/2025.01.09.632283 — neuroscience — Posted on 2025-01-12
3621 Neural decoding of competitive decision-making in Rock-Paper-Scissors using EEG hyperscanning
Moerel, D.; Grootswagers, T.; Chin, J. L. L.; Ciardo, F.; Nijhuis, P.; Quek, G. L.; Smit, S.; Varlet, M.
10.1101/2025.01.09.632285 — neuroscience — Posted on 2025-01-12
3622 The dependency of TMS-evoked potentials on electric-field orientation in the cortex
Grano, I.; Mutanen, T. P.; Nieminen, A. E.; Nieminen, J. O.; Souza, V. H.; Ilmoniemi, R. J.; Lioumis, P.
10.1101/2025.01.10.632309 — neuroscience — Posted on 2025-01-12
3624 OPTN protects retinal ganglion cells and ameliorates neuroinflammation in optic neuropathies
Wang, Q.; Wang, Y.; Jiang, Y. D. D.; Donahue, R.; Cao, G.; Yan, W.; Guo, H.; Hao, J.; Lu, Y.; Wang, Q.; Tian, F.
10.1101/2025.01.09.632264 — neuroscience — Posted on 2025-01-12
3625 Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation
Blaum, N.; Ghelani, T.; Goetz, T.; Chronister, K. S.; Bengochea, M.; Christensen, C. F.; Moulin, T. C.; Ceresnova, L.; Kern, H.; Thomas, U.; Heine, M.; Sigrist, S. J.; Walter, A. M.
10.1101/2025.01.10.632340 — neuroscience — Posted on 2025-01-12
3627 Quantifying Feral Pig Interactions to Inform Disease Transmission Networks
Proboste, T.; Turnlund, A.; Bengsen, A.; Gentle, M.; Wilson, C.; Harriott, L.; Fuller, R.; Marshall, D.; Soares-Magalhaes, R.
10.1101/2024.08.31.610621 — ecology — Posted on 2025-01-12
3628 Vgamma1+ gammadelta T cell-derived IL-4 initiates CD8 T cell immunity
Le, S.; Murphy, D.; Liu, S.; Ge, Z.; May, R.; Cozijnsen, A.; Burn, T.; Jennison, C.; Bachem, A.; Xu, C.; Koay, H.-F.; Schroeder, J.; Gras, S.; Cockburn, I. A.; Bedoui, S.; Mackay, L. K.; Mcfadden, G. I.; Fernandez-Ruiz, D.; Heath, W. R.; Beattie, L.
10.1101/2024.12.06.627130 — immunology — Posted on 2025-01-12
3629 Nurr1 orchestrates claustrum development and functionality
Yan, K.; Newman, A. G.; Lange, P.; Mueller, S.; Foddis, M.; Mantwill, M.; Finke, C.; Koch, S. P.; Boehm-Sturm, P.; Deng, P.; Long, M.; Tarabykin, V.
10.1101/2024.12.31.630879 — neuroscience — Posted on 2025-01-12
3630 TWINKLE: An open-source two-photon microscope for teaching and research
Schottdorf, M.; Rich, P. D.; Diamanti, E. M.; Lin, A.; Tafazoli, S.; Nieh, E. H.; Thiberge, S. Y.
10.1101/2024.09.23.612766 — neuroscience — Posted on 2025-01-12
3631 Neural correlates of approach and avoidance tendencies toward physical activity and sedentary stimuli: An fMRI study
Cheval, B.; Ceravolo, L.; Igloi, K.; Sander, D.; Zimmermann, M.; Van Ruitenbeek, P.; Boisgontier, M. P.
10.1101/2025.01.10.632302 — neuroscience — Posted on 2025-01-12
3632 Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor
Grant, Z. L.; Kuang, S.; Zhang, S.; Horrillo, A. J.; Rao, K. S.; Kameswaran, V.; Joubran, C.; Lau, P. K.; Dong, K.; Yang, B.; Bartosik, W. M.; Zemke, N. R.; Ren, B.; Kathiriya, I. S.; Pollard, K. S.; Bruneau, B. G.
10.1101/2025.01.09.632202 — genomics — Posted on 2025-01-12
3633 Cholesterol deficiency directs autophagy-dependent secretion of extracellular vesicles
Yaeger, J. D.; Sengupta, S.; Walz, A. L.; Morita, M.; Morgan, T. K.; Vermeer, P. D.; Francis, K. R.
10.1101/2025.01.11.632510 — cell biology — Posted on 2025-01-12
3634 Altered microRNA Expression Correlates with Reduced TLR2/4-Dependent Periodontal Inflammation and Bone Resorption Induced by Polymicrobial Infection
Jeepipalli, S.; Gurusamy, P.; Martins, A. R. L.; Colella, E.; Nadakuditi, S. R.; Desaraju, T.; Yada, A.; Onime, J.; William, J.; Bhattacharyya, I.; Chan, E. K. L.; Lakshmyya, K.
10.1101/2025.01.10.632435 — molecular biology — Posted on 2025-01-12
3635 Neural signatures of model-based and model-free reinforcement learning across prefrontal cortex and striatum
Miranda, B.; Butler, J. L.; Malalasekera, W. M. N.; Behrens, T. E. J.; Dayan, P.; Kennerley, S. W.
10.1101/2025.01.11.632388 — neuroscience — Posted on 2025-01-12
3638 Programmable Assembly and Steering of Microbubble Droplets using Ultrasound
Fonseca, A. D. C.; Gautam Kshetri, K.; Boev, D.; Irniger, N.; Nama, N.; Ahmed, D.
10.1101/2025.01.08.631861 — bioengineering — Posted on 2025-01-12
3640 Manual versus automatic annotation of transposable elements: case studies in Drosophila melanogaster and Aedes albopictus, balancing accuracy and biological relevance
Carrasco-Valenzuela, T.; Marino, A.; Storer, J. M.; Bonnici, I.; Mazzoni, C. J.; Fontaine, M. C.; Haudry, A.; Boulesteix, M.; Fiston-Lavier, A.-S.
10.1101/2025.01.10.632341 — genomics — Posted on 2025-01-12
3645 A temporal coordination between Nodal and Wnt signalling governs the emergence of the mammalian body plan
Dias, A.; Pascual-Mas, P.; Torregrosa-Cortes, G.; McNamara, H. M.; Wehmeyer, A. E.; Arnold, S. J.; Martinez Arias, A.
10.1101/2025.01.11.632562 — developmental biology — Posted on 2025-01-12
3646 Extracellular matrix mechanical cues (dys)regulate metabolic redox homeostasis due to impaired autophagic flux
Gerardo, H.; Lourenco, T.; Torres, J.; Ferreira, M.; Aveleira, C.; Simoes, S.; Ferreira, L.; Cavadas, C.; Oliveira, P. J.; Teixeira, J.; Graos, M.
10.1101/2025.01.09.631485 — cell biology — Posted on 2025-01-12
3649 Epigenetic phase variation in the gut microbiome enhances bacterial adaptation
Ni, M.; Fan, Y.; Liu, Y.; Li, Y.; Qiao, W.; Davey, L. E.; Zhang, X.-S.; Ksiezarek, M.; Mead, E.; Touracheau, A.; Jiang, W.; Blaser, M. J.; Valdivia, R.; Fang, G.
10.1101/2025.01.11.632565 — microbiology — Posted on 2025-01-12
3651 Atomic resolution structures of key enzyme MCR in anaerobic methanotrophy reveal novel and extensive post-translational modifications.
Müller, M.-C.; Wissink, M.; Mukherjee, P.; von Possel, N.; Laso-Perez, R.; Engilberge, S.; Carpentier, P.; Kahnt, J.; Wegener, G.; Welte, C.; Wagner, T.
10.1101/2025.01.10.632498 — microbiology — Posted on 2025-01-12
3652 pH adjustment increases biofuel production from inhibitory switchgrass hydrolysates
Barten, L. M.; Crandall, J. G.; Xie, D.; Serate, J.; Handowski, E.; Jen, A.; Overmyer, K. A.; Coon, J. J.; Hittinger, C. T.; Landick, R.; Zhang, Y.; Sato, T. K.
10.1101/2025.01.10.632484 — microbiology — Posted on 2025-01-12
3654 Dynamic Norm-Based Coding of Vocal Identity in the Primate Auditory Cortex
Esposito, Y.; Boe, L.-J.; Trapeau, R.; Renaud, L.; Brochier, T.; Giamundo, M.; Belin, P.
10.1101/2025.01.10.632201 — neuroscience — Posted on 2025-01-12
3655 Collagen Hydrogel Tube Microbioreactors for Cell and Tissue Manufacturing
Yang, Y.; Wu, X.; Pan, Y.; Wang, Y.; Lian, X.; Dong, C.; Liu, W.; Wang, S.; Lei, Y.
10.1101/2025.01.08.631570 — bioengineering — Posted on 2025-01-12
3659 Genomes of the entomopathogenic nematode Steinernema hermaphroditum and its associated bacteria
Schwarz, E. M.; Baniya, A.; Heppert, J. K.; Schwartz, H. T.; Tan, C.-H.; Antoshechkin, I.; Sternberg, P. W.; Goodrich-Blair, H.; Dillman, A. R.
10.1101/2025.01.09.632278 — genomics — Posted on 2025-01-12
3662 Testing for changes in population trends from low-cost ecological count data
Singer, L.; Caduff, M.; Aebischer, T.; Tabiti, P.; Freiberg, A.; Ingensand, J.; Leuenberger, C.; Wegmann, D.
10.1101/2025.01.08.631844 — ecology — Posted on 2025-01-12
3664 High Performance protocol for ultra-short DNA sequencing using Oxford Nanopore Technology (ONT)
Zemaitis, L.; Palepsiene, R.; Juzenas, S.; Alzbutas, G.; Burgi, P.-Y.; Heinis, T.; Charmet, J.; Angeloni Suter, S.; Jost, M.; Raisutis, R.; Simmel, F.; Galminas, I.
10.1101/2025.01.10.632410 — molecular biology — Posted on 2025-01-12
3668 Tke5 is a novel Pseudomonas putida toxin that depolarises membranes killing plant pathogens
Velazquez, C.; Arce-Rodriguez, A.; Altuna-Alvarez, J.; Rojas-Palomino, J.; Flores-Ceron, A.; Ruiz, A.; Gonzalez-Magana, A.; Queralt-Martin, M.; Alcaraz, A.; Albesa-Jove, D.; Bernal, P.
10.1101/2025.01.11.632536 — microbiology — Posted on 2025-01-12
3669 Genetic Mapping of All Human Paralog Pairs to Characterize Synthetic Lethality and Buffering
Flister, M. J.; Verduzco, D.; Petiwala, S.; Carneiro Logo, T.; Ghekas, C.; Shi, X.; Lu, C.; Dezso, Z. J.
10.1101/2024.07.16.603642 — cancer biology — Posted on 2025-01-11
3671 PDZ Domains from the Junctional Proteins Afadin and ZO-1 Act as Mechanosensors
Vachharajani, V. T.; DeJong, M. P.; Dutta, S.; Chapman, J.; Ghosh, E.; Singharoy, A.; Dunn, A. R.
10.1101/2023.09.24.559210 — biophysics — Posted on 2025-01-11
3677 Differential Expression Analysis for Spatially Correlated Data
Vasconcelos, A. G.; McGuire, D.; Simon, N.; Danaher, P.; Shojaie, A.
10.1101/2024.08.02.606405 — genomics — Posted on 2025-01-11
3678 GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis
Bisson, J. A.; Gordillo, M.; Kumar, R.; de Silva, N.; Yang, E.; Banks, K. M.; Shi, Z.-D.; Lee, K.; Yang, D.; Chung, W. K.; Huangfu, D.; Evans, T.
10.1101/2024.07.09.602666 — developmental biology — Posted on 2025-01-11
3679 EOR-1/PLZF-regulated WAH-1/AIF sequentially promotes early and late stages of non-apoptotic corpse removal
Rather, N.; Williams, M.; Elkhalil, A.; Sharmin, R.; Juanez, K.; Clark, G.; Shaham, S.; Ghose, P.
10.1101/2024.12.04.626465 — cell biology — Posted on 2025-01-11
3680 The lipidome and proteome of high-density lipoprotein are altered in menopause
Lehti, S.; Korhonen, T.-M.; Soliymani, R.; Ruhanen, H.; Lahteenmaki, E.; Palviainen, M.; Siljander, P.; Lalowski, M.; Kakela, R.; Lehti, M.; Laakkonen, E. K.
10.1101/2024.01.10.574516 — molecular biology — Posted on 2025-01-11
3682 Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever
Srour, S.; ElGhazaly, M.; O'Connor, D.; Gibani, M. M.; Darton, T. C.; Pollard, A. J.; Collins, M. O.; Humphreys, D.
10.1101/2024.12.13.628371 — microbiology — Posted on 2025-01-11
3683 A comparative evaluation of CRISPR-Cas9 allele editing systems in Candida auris: challenging research in a challenging bug
Sofras, D.; Carolus, H.; Subotic, A.; Lobo Romero, C.; Ennis, C. L.; Hernday, A. D.; Nobile, C. J.; Ryback, J.; Van Dijck, P.
10.1101/2025.01.09.632232 — microbiology — Posted on 2025-01-11
3685 Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain: replication and extension with 7 Tesla fMRI
Zhang, J.; Chen, D.; Srirangarajan, T.; Theriault, J.; Kragel, P. A.; Hartley, L.; Lee, K. M.; McVeigh, K.; Wager, T.; Wald, L. L.; Satpute, A. B.; Quigley, K. S.; Whitfield-Gabrieli, S.; Barrett, L. F.; Bianciardi, M.
10.1101/2023.07.20.548178 — neuroscience — Posted on 2025-01-11
3686 PinkyCaMP a mScarlet-based calcium sensor with exceptional brightness, photostability, and multiplexing capabilities
Fink, R.; Imai, S.; Gockel, N.; Lauer, G.; Renken, K.; Wietek, J.; Lamothe-Molina, P. J.; Furhmann, F.; Mittag, M.; Ziebarth, T.; Canziani, A.; Kubitschke, M.; Kistmacher, V.; Kretschmer, A.; Sebastian, E.; Schmitz, D.; Terai, T.; Gründemann, J.; Hassan, S.; Patriarchi, T.; Reiner, A.; Fuhrmann, M.; Campbell, R. E.; Masseck, O. A.
10.1101/2024.12.16.628673 — neuroscience — Posted on 2025-01-11
3687 Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking
Karashchuk, L.; Li, J. S. L.; Chou, G. M.; Walling-Bell, S.; Brunton, S. L.; Tuthill, J. C.; Brunton, B. W.
10.1101/2024.04.18.589965 — neuroscience — Posted on 2025-01-11
3688 Incomplete adaptation to surface movement during hand reaching
Balestrucci, P.; Bianchi, M.; Ryan, C. P.; Daniele, G.; Flamini, A.; Valente, F.; Lacquaniti, F.; Moscatelli, A.
10.1101/2024.12.18.629126 — neuroscience — Posted on 2025-01-11
3691 Single-cell RNA sequencing across isogenic FUS and TARDBP ALS lines reveals a shared early mitochondrial dysfunction unique to motor neurons.
Schweingruber, C.; Nijssen, J.; Mechtersheimer, J.; Reber, S.; Leboeuf, M.; Mei, I.; Hedges, E.; Keuper, M.; Aguila Benitez, J.; O'Brien, N.; Radoi, V.; Jastroch, M.; Ruepp, M.-D.; Hedlund, E.
10.1101/2023.03.16.531876 — neuroscience — Posted on 2025-01-11
3692 Expert Navigators Deploy Rational Complexity-Based Decision Precaching for Large-Scale Real-World Planning
Fernandez Velasco, P.; Griesbauer, E.-M.; Brunec, I.; Morley, J.; Manley, E.; McNamee, D.; Spiers, H.
10.1101/2024.03.25.586612 — neuroscience — Posted on 2025-01-11
3693 C12ORF57: a novel principal regulator of synaptic AMPA currents and excitatory neuronal homeostasis
Jiang, R.; Chouchane, M.; Moey, C.; Bunt, J.; Li, J.; Allkuraya, F.; Alobeid, E.; Richards, L.; Ullian, E.; Sherr, E.
10.1101/2025.01.08.632037 — neuroscience — Posted on 2025-01-11
3694 Preoperative Brain Mapping Predicts Language Outcomes after Eloquent Tumor Resection
Muir, M.; Noll, K.; Prinsloo, S.; Michener, H.; Asman, P.; Traylor, J.; Kumar, V.; Ene, C.; Forkel, S.; Prabhu, S.
10.1101/2024.05.06.592752 — neuroscience — Posted on 2025-01-11
3696 BIBSNet: A Deep Learning Baby Image Brain Segmentation Network for MRI Scans
Hendrickson, T. J.; Reiners, P.; Moore, L. A.; Lundquist, J. T.; Fayzullobekova, B.; Perrone, A. J.; Lee, E. G.; Moser, J.; Day, T. K. M.; Alexopoulos, D.; Styner, M.; Kardan, O.; Chamberlain, T. A.; Mummaneni, A.; Caldas, H. A.; Bower, B.; Stoyell, S.; Martin, T.; Sung, S.; Fair, E.; Carter, K.; Uriarte-Lopez, J.; Rueter, A. R.; Yacoub, E.; Rosenberg, M. D.; Smyser, C. D.; Elison, J. T.; Graham, A.; Fair, D. A.; Feczko, E.
10.1101/2023.03.22.533696 — neuroscience — Posted on 2025-01-11
3697 Gustatory sensitivity to amino acids in bumblebees
Rossoni, S.; Parkinson, R. H.; Niven, J. E.; Nicholls, E.
10.1101/2024.11.28.625904 — neuroscience — Posted on 2025-01-11
3699 Sequence termination cues drive habits via dopamine-mediated credit assignment
Magnard, R.; Cheng, Y.; Zhou, J.; Province, H.; Thiriet, N.; Janak, P. H.; Vandaele, Y.
10.1101/2024.10.16.618735 — neuroscience — Posted on 2025-01-11
3702 Genetic barcodes for ash (Fraxinus) species and generation of new wide hybrids
Plumb, W.; Kelly, L.; Mullender, J.; Powell, R.; Csiba, L.; Gorriz, M. N.; Carey, D.; Mason, M.; Crowther, W.; Koch, J.; Douglas, G.; Buggs, R.
10.1101/2024.02.19.581010 — plant biology — Posted on 2025-01-11
3706 Searching for Sulfotyrosines (sY) in a HA(pY)STACK
Tzvetkov, J.; Eyers, C. E.; Eyers, P. A.; Ramsbottom, K. A.; Oswald, S. O.; Harris, J. A.; Sun, Z.; Deutsch, E. W.; Jones, A. R.
10.1101/2024.10.14.618131 — bioinformatics — Posted on 2025-01-11
3707 Accurate and General DNA Representations Emerge from Genome Foundation Models at Scale
Ellington, C. N.; Sun, N.; Ho, N.; Tao, T.; Mahbub, S.; Li, D.; Zhuang, Y.; Wang, H.; Song, L.; Xing, E. P.
10.1101/2024.12.01.625444 — bioinformatics — Posted on 2025-01-11
3709 Audiovisual cues must be predictable and win-paired to drive risky choice
Hathaway, B. A.; Kim, D. R.; Malhas, S. B. A.; Hrelja, K. M.; Kerker, L.; Hynes, T. J.; Harris, C.; Langdon, A. J.; Winstanley, C. A.
10.1101/2022.09.20.507379 — animal behavior and cognition — Posted on 2025-01-11
3715 C-terminal tagging impairs AGO2 function
Shah, K. M.; Crozier, A. F. F.; Assaraf, A. A.; Arya, M.; Grevitt, P.; Mardakheh, F.; Plevin, M. J.; Sharp, T. V.
10.1101/2023.11.20.567203 — molecular biology — Posted on 2025-01-11
3720 Respiration facilitates behaviour during multisensory integration
Saltafossi, M.; Zaccaro, A.; Kluger, D. S.; Perrucci, M. G.; Ferri, F.; Costantini, M.
10.1101/2025.01.10.632352 — neuroscience — Posted on 2025-01-11
3721 Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner
Roy, E.; Wang, Q.; Huang, K.; Li, S.; Fan, Y.; Escobar, E.; Huang, S.; Herrera, J.; Li, W.; Pridans, C.; Zhou, X.; Ju, C.; Cao, W.
10.1101/2025.01.10.632400 — neuroscience — Posted on 2025-01-11
3723 Enhancer Dynamics and Spatial Organization Drive Anatomically Restricted Cellular States in the Human Spinal Cord
Kandror, E. K.; Wang, A.; Carriere, M.; Peterson, A.; Liao, W.; Tjarnberg, A.; Fung, J. H.; Mahbubani, K. T.; Loper, J.; Pangburn, W.; Xu, Y.; Saeb-Parsy, K.; Rabadan, R.; Maniatis, T.; Rizvi, A. H.
10.1101/2025.01.10.632483 — neuroscience — Posted on 2025-01-11
3725 Subthalamic Signature of Freezing of Gait in Parkinson Disease
Collomb-Clerc, A.; Yeche, M.; Demain, A.; Van Hamme, A.; Olivier, C.; Belaid, H.; Ziri, D.; Derrey, S.; Fernandez-Vidal, S.; Lehongre, K.; Karachi, C.; Lau, B.; Welter, M.-L.
10.1101/2025.01.10.632393 — neuroscience — Posted on 2025-01-11
3728 Influence of solvent, sex, and age on pharmacokinetic and acute behavioral effects of vaporized cannabis extract in mice
Wesbrook, S. R.; Jensen, A. L.; Copeland-Solorzano, V.; Buursma, J.; Freeby, G.; von Melville, T.; Edwards, T.; Hayashi, K.; McLaughlin, R. J.; Delevich, K. M.
10.1101/2025.01.10.632469 — animal behavior and cognition — Posted on 2025-01-11
3729 Hippocampus does not appear to be a major target of thalamic nucleus reuniens
Andrianova, L.; Brady, E. S.; Margetts-Smith, G.; Kohli, S.; Cavanagh, J.; McBain, C. J.; Craig, M. T.
10.1101/2021.09.30.462517 — neuroscience — Posted on 2025-01-11
3731 Quantifying Differences in Neural Population Activity With Shape Metrics
Barbosa, J.; Nejatbakhsh, A.; Duong, L. R.; Harvey, S. E.; Brincat, S. L.; Siegel, M.; Miller, E. K.; Williams, A. H.
10.1101/2025.01.10.632411 — neuroscience — Posted on 2025-01-11
3732 Spike rate inference from mouse spinal cord calcium imaging data
Rupprecht, P.; Fan, W.; Sullivan, S. J.; Helmchen, F.; Sdrulla, A.
10.1101/2024.07.17.603957 — neuroscience — Posted on 2025-01-11
3733 Shaping the structural dynamics of motor learning through cueing during sleep
Stee, W.; Legouhy, A.; Guerreri, M.; Foti, M. C.; Lina, J.-M.; Zhang, H.; Peigneux, P.
10.1101/2024.08.16.608370 — neuroscience — Posted on 2025-01-11
3734 Reduced and Redundant: Information Processing of Prediction Errors during Sleep
Blume, C.; Dauphin, M.; Niedernhuber, M.; Spitschan, M.; Meyer, M. P.; Cajochen, C.; Bekinschtein, T.; Canales-Johnson, A.
10.1101/2024.12.06.627143 — neuroscience — Posted on 2025-01-11
3736 Scaling of mouse somitogenesis by coupling of cell cycle to segmentation clock oscillations
van Oostrom, M. v.; Li, Y. I.; Meijer, W. H. M.; Noordzij, T. E. J. C.; Fountas, C.; Timmers, E.; Korving, J.; Thomas, W. M.; Simons, B. D.; Sonnen, I.
10.1101/2025.01.10.632257 — developmental biology — Posted on 2025-01-11
3743 Whole-body coarticulation reflects expertise in sport climbing
Maselli, A.; Musculus, L.; Moretti, R.; d'Avella, A.; Raab, M.; Pezzulo, G.
10.1101/2025.01.10.632403 — neuroscience — Posted on 2025-01-11
3746 Attentional enhancement and suppression of stimulus-synchronized BOLD oscillations
Rafeh, R. W.; Ngo, G. N.; Muller, L. E.; Khan, A. R.; Menon, R. S.; Mur, M.; Schmitz, T. W.
10.1101/2025.01.10.632431 — neuroscience — Posted on 2025-01-11
3747 Decoding Gene Networks Controlling Hypothalamic and Prethalamic Neuron Development.
Kim, D. W.; Duncan, L.; Xu, J.; Chang, M.; Sorensen, S. S.; Terrillin, C.; Kanold, P.; Place, E. S.; Blackshaw, S.
10.1101/2025.01.10.632449 — neuroscience — Posted on 2025-01-11
3751 Engineering Infrared Light Detection in Blind Human Retina Using Ultrasensitive Human TRPV1 Channels
Chevalier, M.; Fadel, F.; Majer, T.; Magda, D. P.; Gerendas, L.; Kilin, F.; Nagy, Z. Z.; Szabo, A.; Roska, B.; Testa-Silva, G.
10.1101/2025.01.08.631889 — bioengineering — Posted on 2025-01-11
3753 Single-molecule assay reveals the impact of composition, RNA duplex, and inhibitors on the binding dynamics of SARS-CoV-2 polymerase complex
Lovell, T. C.; Dewling, H. A.; Li, C. X.; Lee, H. W.; Gordon, C. J.; Kocincova, D.; Badmalia, M. D.; Tchesnokov, E. P.; Gotte, M.; Cosa, G.
10.1101/2025.01.10.632212 — biophysics — Posted on 2025-01-11
3754 Protenix - Advancing Structure Prediction Through a Comprehensive AlphaFold3 Reproduction
chen, x.; zhang, y.; lu, c.; ma, w.; guan, j.; gong, c.; yang, j.; zhang, h.; zhang, k.; wu, s.; zhou, k.; yang, y.; liu, z.; wang, l.; shi, b.; shi, s.; xiao, w.
10.1101/2025.01.08.631967 — bioinformatics — Posted on 2025-01-11
3756 Genome-wide CRISPR knockout screening with viral replicons for identification of host factors involved in viral replication
Cheng, K. W.; Bhave, M.; Markhard, A.; Peng, D. L.; Bhatt, K. D.; Travisano, K. A.; Medicielo, J. V.; Lembirik, S.; Njoya, L.; Anantpadma, M.; Kuhn, J. H.; Puschnik, A. S.; Kistler, A. L.
10.1101/2025.01.09.632058 — genomics — Posted on 2025-01-11
3758 Local erythropoiesis directs oxygen availability in bone fracture repair
Lang, A.; Collins, J. M.; Nijsure, M. P.; Belali, S.; Khan, M. P.; Moharrer, Y.; Schipani, E.; Yien, Y. Y.; Fan, Y.; Gelinsky, M.; Vinogradov, S. A.; Koch, C.; Boerckel, J. D.
10.1101/2025.01.10.632440 — cell biology — Posted on 2025-01-11
3759 The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptors
Rios Carrasco, M.; Lin, T.-H.; Zhu, X.; Gabarroca Garcia, A.; Uslu, E.; Liang, R.; Spruit, C.; Richard, M.; Boons, G.-J.; Wilson, I. A.; de Vries, R. P.
10.1101/2025.01.10.632119 — microbiology — Posted on 2025-01-11
3760 Uptake of Prochlorococcus-derived metabolites by Alteromonas macleodii MIT1002 shows high levels of substrate specificity
Halloran, K. H.; Braakman, R.; Coe, A.; Swarr, G.; Kido Soule, M. C.; Chisholm, S. W.; Kujawinski, E. B.
10.1101/2025.01.10.632383 — microbiology — Posted on 2025-01-11
3761 Timed chromatin invasion during mitosis governs prototype foamy virus integration site selection and infectivity
Lagadec, F.; Singh, P. K.; Calmels, C.; Lapaillerie, D.; Lindemann, D.; Parissi, V.; Cherepanov, P.; Engelman, A. N.; Lesbats, P.
10.1101/2025.01.10.632130 — microbiology — Posted on 2025-01-11
3762 Common symbiotic signalling pathway not essential for formation of functional mutualisms with endophytic fungi
Williams, A.; Sinanaj, B.; Rodriguez-Morelos, V.; Prout, J.; Howard, N. O. A.; Durant, E.; Pressel, S.; Field, K.
10.1101/2025.01.10.632311 — microbiology — Posted on 2025-01-11
3763 Dual-use virulence factors of the opportunistic pathogen Chromobacterium haemolyticum mediate haemolysis and colonization
Dumjahn, L.; Wein, P.; Molloy, E. M.; Scherlach, K.; Trottmann, F.; Meisinger, P.; Judd, L. M.; Pidot, S. J.; Stinear, T. P.; Richter, I.; Hertweck, C.
10.1101/2025.01.10.632398 — microbiology — Posted on 2025-01-11
3764 Chemoproteomic Profiling of C. albicans for Characterization of Anti-fungal Kinase Inhibitors
Shirley, D. J.; Nandakumar, M.; Cabrera, A.; Yiu, B.; Puumala, E.; Liu, Z.; Robbins, N.; Whitesell, L.; Smith, J. L.; Lyons, S. P.; Mordant, A. L.; Herring, L. E.; Graves, L. M.; Counago, R. L. M.; Drewry, D. H.; Cowen, L. E.; Willson, T. M.
10.1101/2025.01.10.632200 — microbiology — Posted on 2025-01-11
3765 Single-cell genomics of single soil aggregates: methodological assessment and potential implications with a focus on nitrogen metabolism
Matsumura, E.; Kato, H.; Hara, S.; Ohbayashi, T.; Ito, K.; Shingubara, R.; Kawakami, T.; Mitsunobu, S.; Saeki, T.; Tsuda, S.; Minamisawa, K.; Wagai, R.
10.1101/2025.01.09.632267 — microbiology — Posted on 2025-01-11
3766 Temporal Dynamics of Transcriptional Responses to Repeated mRNA Vaccination: Insights from Third Dose Profiling
Rinchai, D.; Deola, S.; Kabeer, B. S. A.; Gentilcore, G.; Toufiq, M.; Mathew, L. S.; Liu, L.; Vempalli, F.; Mubarak, G.; Lorenz, S.; Augustine, T.; van Panhuys, N.; Bedognetti, D.; Grivel, J.-C.; Chaussabel, D.
10.1101/2025.01.09.631990 — immunology — Posted on 2025-01-11
3767 Astroglial deficiency for oligophrenin-1 contributes to intellectual disability
Cresto, N.; Ezan, P.; Pillet, L.-E.; Mazaud, D.; Mailly, P.; Bemelmans, A.; Meziane, H.; Selloum, M.; Sorg, T.; Marchi, N.; Herault, Y.; BIlluart, P.; Rouach, N.
10.1101/2025.01.09.632152 — neuroscience — Posted on 2025-01-11
3768 Collateral connectomes of Esr1-positive hypothalamic neurons modulate defensive behavior plasticity
Csillag, V.; Forastieri, C.; Szucs, G. M.; Vidal, I. T.; Hiriart, M. B.; Lavis, L. D.; Calvigioni, D.; Fuzik, J.
10.1101/2025.01.10.632334 — neuroscience — Posted on 2025-01-11
3769 MiRNA Locker: A Modularized DNA Assembly As miRNA Inhibitors
Zhu, L.; Min, L.; Zhu, C.-s.; Wu, X.; Li, W.; Ma, J.; Lei, Y.; Gao, C.; Qiu, X.; Liu, C.
10.1101/2025.01.10.632138 — synthetic biology — Posted on 2025-01-11
3770 A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
Klein, M.; Das, A.; BERA, S. C.; Anderson, T. K.; Kocincova, D.; Lee, H. W.; Wang, B.; Papini, F. S.; Marecki, J. C.; Arnold, J. J.; Cameron, C. E.; Raney, K. D.; Artsimovitch, I.; Gotte, M.; Kirchdoerfer, R.; Depken, M.; Dulin, D.
10.1101/2025.01.10.632299 — biophysics — Posted on 2025-01-11
3772 Plasma-driven biocatalysis using the cytochrome P450 enzyme CYP152BSβ
Dirks, T.; Klopsch, S.; Stoesser, D.; Trenkle, S. D.; Yayci, A.; Schüttler, S.; Golda, J.; Bandow, J. E.
10.1101/2025.01.09.631812 — biochemistry — Posted on 2025-01-11
3774 iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade
Sroka, T. J.; Sanwald, L. K.; Prasai, A.; Hoeren, J.; von der Malsburg, K.; Chaumet, V.; Haberkant, P.; Feistel, K.; Mick, D. U.
10.1101/2025.01.10.632381 — biochemistry — Posted on 2025-01-11
3775 Evolution of CYP71D as a driving force of the diversification of monoterpene indole alkaloid biosynthesis
Besseau, S.; Durand, M.; Zamar, D.-L.; Lezin, E.; Meteignier, L.-V.; Birer Williams, C.; Dutilleul, C.; Perrot, T.; Lanoue, A.; Oudin, A.; Papon, N.; Sun, C.; St-Pierre, B.; Courdavault, V.
10.1101/2025.01.09.632084 — biochemistry — Posted on 2025-01-11
3777 Processing of Genomic RNAs by Dicer in Bat Cells Limits SARS-CoV-2 Replication
Owolabi, I. J.; Karim, S.; Khanal, S.; Valdivia, S.; Frenzel, C.; Bai, F.; Flynt, A. S.
10.1101/2025.01.10.632425 — molecular biology — Posted on 2025-01-10
3778 Host-specific microbiome and genomic signatures in Bifidobacterium reveal co-evolutionary and functional adaptations across diverse animal hosts
Kujawska, M.; Seki, D.; Chalklen, L.; Malsom, J.; Goatcher, S.; Christoforou, I.; Mitra, S.; Crouch, L.; Hall, L. J.
10.1101/2025.01.10.632322 — microbiology — Posted on 2025-01-11
3779 Infectome analysis of bat kidneys from Yunnan province, China, reveals close relatives of Hendra-Nipah viruses and prevalent bacterial and eukaryotic pathogens
Kuang, G.; Yang, T.; Yang, W.; Wang, J.; Pan, H.; Pan, Y.; Gou, Q.-y.; Wu, W.-c.; Wang, J.; Yang, L.; Han, X.; Chen, Y.-q.; Eden, J.-S.; Holmes, E. C.; Shi, M.; Feng, Y.
10.1101/2025.01.10.632301 — microbiology — Posted on 2025-01-11
3780 Design of SARS-CoV-2 RBD Immunogens to Focus Immune Responses Towards Conserved Coronavirus Epitopes
Harris, C. M.; Kapingidza, A. B.; San, J. E.; Christopher, J.; Gavitt, T.; Rhodes, B.; Janowska, K.; O'Donnell, C.; Lindenberger, J.; Huang, X.; Sammour, S.; Berry, M.; Barr, M.; Parks, R.; Newman, A.; Overton, M.; Oguin, T.; Acharya, P.; Haynes, B. F.; Saunders, K. O.; Wiehe, K.; Azoitei, M. L.
10.1101/2025.01.09.632180 — immunology — Posted on 2025-01-10
3781 Social dysfunction relates to altered default mode network functional integrity across neuropsychiatric disorders: A replication and generalization study
Braak, S.; Mennes, M.; Su, T.; Pijnenburg, Y. A. L.; Bakker, G.; Arango, C.; van der Wee, N.; Bauduin, S.; Moya, A. O.-T.; Lopez-Morinigo, J.-D.; Dawson, G. R.; Abrahams, A. B.; Beckenstrom, A. C.; Beckmann, C. F.; Marston, H. M.; Penninx, B. W. J. H.; Kas, M. J. H.
10.1101/2025.01.09.631642 — neuroscience — Posted on 2025-01-10
3782 Neural mechanisms of object prioritization in vision
Grignolio, D.; Meyyappan, S.; Geng, J.; Mangun, G. R.; Hickey, C.
10.1101/2025.01.09.632156 — neuroscience — Posted on 2025-01-10
3783 Epigenome-wide analysis reveals novel DNA methylation signatures significantly associated with the infant pupillary light reflex, a candidate intermediate phenotype for autism.
Fish, L.; Gliga, T.; Gui, A.; Begum Ali, J.; Mason, L.; Johnson, M. H.; Charman, T.; Falck-Ytter, T.; Jones, E. J.; Kandaswamy, R.; Happe, F.; Wong, C. C. Y.
10.1101/2025.01.10.632385 — neuroscience — Posted on 2025-01-10
3784 Monocarboxylate transporter 2 is required for the maintenance of myelin and axonal integrity by oligodendrocytes
Izagirre-Urizar, L.; Mora-Huerta, L.; Soler-Saez, I.; Morales-Gallel, R.; Ulloa-Navas, M. J.; Chara, J.-C.; Calovi, S.; Deboux, C. J.; Merino-Cacho, L.; Domercq, M.; Zugaza, J.-L.; Pellerin, L.; Garcia-Garcia, F.; Garcia-Verdugo, J. M.; Matute, C.; Nait Oumesmar, B.; Tepavcevic, V.
10.1101/2025.01.10.632306 — neuroscience — Posted on 2025-01-10
3788 Minimally Invasive DNA-Mediated Photostabilization for Extended Single-Molecule and Super-resolution Imaging
Scheckenbach, M.; Close, C.; Bauer, J.; Grabenhorst, L.; Cole, F.; Koehler, J.; Matikonda, S. S.; Zhang, L.; Cordes, T.; Schnermann, M.; Herrmann, A.; Tinnefeld, P.; Szalai, A. M.; Glembockyte, V.
10.1101/2025.01.08.631860 — biophysics — Posted on 2025-01-10
3789 Atomistic Mechanism of Non-Canonical Voltage Gating in TREK K2P Channels
Sun, H.; Aldakul, Y.; Schewe, M.; Diez, C.; Hwang, S.; Baukrowitz, T.
10.1101/2025.01.08.631886 — biophysics — Posted on 2025-01-10
3792 Subcontinental Genetic Diversity in the All of Us Research Program: Implications for Biomedical Research
Gouveia, M. H.; Meeks, K. A. C.; Pua, V. O. B.; Leal, T. P.; Kehdy, F. S. G.; Mogire, R.; Doumatey, A. P.; Tarazona-Santos, E.; Kittles, R.; Mata, I. F.; O'Connor, T. D.; Adeyemo, A.; Shriner, D.; Rotimi, C.
10.1101/2025.01.09.632250 — genomics — Posted on 2025-01-10
3794 Derivation of cardiac reference ranges for Mus musculus using the Collaborative Cross and identification of new cardiac models
Threadgill, D. W.; Popp, J. L.; Patel, K.; Cuomo, D.; Lynch, R. M.; Leung, S. W.; Berridge, B. R.; Rusyn, I.; Chiu, W. A.
10.1101/2025.01.08.631983 — genetics — Posted on 2025-01-10
3796 Sex chromosomes and chromosomal rearrangements are key to behavioural sexual isolation in Jaera albifrons marine isopods
Ribardiere, A.; Daguin-Thiebaut, C.; Coudret, J.; Le Corguille, G.; Avia, K.; Houbin, C.; Loisel, S.; Gagnaire, P.-A.; Broquet, T.
10.1101/2025.01.08.631900 — evolutionary biology — Posted on 2025-01-10
3797 Resolving forebrain developmental organisation by analysis of differential growth patterns
Manning, E.; Chinnaiya, K.; Furley, C.; Kim, D. W.; Blackshaw, S.; Placzek, M.; Place, E.
10.1101/2025.01.10.632351 — developmental biology — Posted on 2025-01-10
3798 Secreted Frizzled-Related Protein 1a regulates hematopoietic development in a dose-dependent manner
Ide, A. D.; Carpenter, K. A.; Elaswad, M.; Opria, K.; Marcellin, K.; Gilliland, C.; Grainger, S.
10.1101/2025.01.10.632371 — developmental biology — Posted on 2025-01-10
3801 Large extracellular vesicles containing mitochondria (EVMs) derived from Alzheimer disease cells harbor pathologic functional and molecular profiles and spread mitochondrial dysfunctions
Eysert, F.; Legros, V.; Gay, A.-S.; Debayle, D.; Lacas-Gervais, S.; Kaidi, k.; Chevreux, G.; Lagarde, J.; Checler, F.; Sarazin, M.; Potier, M.-C.; Chami, M.
10.1101/2025.01.08.631851 — neuroscience — Posted on 2025-01-10
3802 Phosphoproteomics reveals novel BCR::ABL1-independent mechanisms of resistance in chronic myeloid leukemia
Bica, V.; Venafra, V.; Massacci, G.; Graziosi, S.; Gualdi, S.; Minnella, G.; Sora, F.; Chiusolo, P.; Brunetti, M. E.; Napolitano, G.; Breccia, M.; Mougiakakos, D.; Boettcher, M.; Fischer, T.; Perfetto, L.; Sacco, F.
10.1101/2025.01.08.631869 — systems biology — Posted on 2025-01-10
3803 Revisiting the Central Dogma: the distinct roles of genome, methylation, transcription, and translation on protein expression in Arabidopsis thaliana
Zhong, Z.; Bailey, M.; Kim, Y.-I.; Pesaran-Afsharyan, N.; Parker, B.; Arathoon, L.; Li, X.; Rundle, C. A.; Behrens, A.; Nedialkova, D. D.; Slavov, G.; Hassani-Pak, K.; Lilley, K. S.; Theodoulou, F. L.; Mott, R.
10.1101/2025.01.08.631880 — plant biology — Posted on 2025-01-10
3805 A dietary intervention following incretin analog treatment restores adipose tissue functions in diet-induced obese mice
Seuntjens, J.; De Gols, J.; Davies, B.; Van Looy, F.; Stockmans, I.; Moermans, K.; Carmeliet, G.; Matthys, C.; Vangoitsenhoven, R.; Van der Schueren, B.; Stegen, S.; Shimobayashi, M.
10.1101/2025.01.08.631845 — physiology — Posted on 2025-01-10
3807 Lithography-free Water Stable Conductive Polymer Nanowires
Hughes, D.; Mousa, A. H.; Musumeci, C.; Larsson, M.; Shameem, M. A.; Aydemir, U.; Schmiderer, L.; Larsson, J.; Berggren, M.; Ek, F.; Olsson, R.; Hjort, M.
10.1101/2025.01.08.631660 — biophysics — Posted on 2025-01-10
3809 Spatio-temporal dynamics of ingroup interactions in macaques
Kononowicz, T. W.; Rolando, F.; Maigre, L.; Sirigu, A.; Duhamel, J.-R.; Ballesta, S.; Wirth, S.
10.1101/2025.01.10.632303 — animal behavior and cognition — Posted on 2025-01-10
3810 Guidestar: a spike-in approach to improve RNA detection accuracy in imaging-based spatial transcriptomics
Tan, J. X. M.; Wang, L.; Seow, W. Y.; Boonruangkan, J.; Huang, M.; Toh, J.; Chen, K. H.; Chou, N.
10.1101/2025.01.09.632272 — genomics — Posted on 2025-01-10
3812 Freshwater fish community assessment using eDNA metabarcoding vs. capture-based methods: differences in efficiency and resolution coupled to habitat and ecology
Curto, M.; Batista, S.; Santos, C. D.; Ribeiro, F.; Nogueira, S.; Ribeiro, D.; Prindle, B.; Licari, D.; Riccioni, G.; Dias, D.; Pina-Martins, F.; Jentoft, S.; Verissimo, A.; Alves, M. J.; Gante, H. F.
10.1101/2025.01.08.631834 — ecology — Posted on 2025-01-10
3816 A zebrafish model of nicotinamide adenine dinucleotide (NAD+) deficiency-derived congenital disorders
Tsurho, V.; Gilliland, C.; Ensing, J.; Vansickle, E.; Lanning, N. J.; Mark, P. R.; Grainger, S.
10.1101/2025.01.10.632366 — developmental biology — Posted on 2025-01-10
3817 Epithelial to Mesenchymal Transition in the Endometrium Mediated by HOXA10 drives Embryo Implantation
Ashary, N. S.; Suresh, S.; Bhide, A.; Shayamal, S.; N, P.; Mishra, A.; A, A.; Hansda, S.; BV, H.; Jolly, M. K.; Modi, D.
10.1101/2025.01.10.631632 — developmental biology — Posted on 2025-01-10
3818 A cytoskeletal scaffold promotes motile cilia assembly by regulating transition-zone integrity
Park, H.; Choi, M.; Cheung, H. O.-L.; Zhang, Y.; Makino, S.; Yoshikawa, Y.; Qi, H.; Liu, Z.; Lan, G.; Fu, G.; Wang, Q.; Guo, S. S.; Liu, P.; Liu, Z.; Ti, S.-C.; Wang, W.-J.; Li, X. D.; Ni, T.; Hui, C. C.; He, M.
10.1101/2025.01.10.632296 — developmental biology — Posted on 2025-01-10
3819 Deep topic modeling of spatial transcriptomics in the rheumatoid arthritis synovium identifies distinct classes of ectopic lymphoid structures
Periyakoil, P. K.; Smith, M. H.; Kshirsagar, M.; Ramirez, D.; DiCarlo, E. F.; Goodman, S. M.; Rudensky, A.; Donlin, L.; Leslie, C. S.
10.1101/2025.01.08.631928 — immunology — Posted on 2025-01-10
3820 Hypoxia-related immune subsets induced by Salmonella Typhi infection link early bacterial gut invasion to human infection outcomes
Bossel Ben-Moshe, N.; Hen Avivi, S.; Levy Efrati, L.; Vainman, L.; Hill, J.; OConnor, D.; Verheul, M.; Stockdale, L.; McLean, F.; Pollard, A.; Avraham, R.
10.1101/2025.01.08.631852 — immunology — Posted on 2025-01-10
3822 A critical initialization for biological neural networks
Pachitariu, M.; Zhong, L.; Gracias, A.; Minisi, A.; Lopez, C.; Stringer, C.
10.1101/2025.01.10.632397 — neuroscience — Posted on 2025-01-10
3823 Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes
Bin, J. M.; Emberley, K.; Buscham, T. J.; Eichel-Vogel, M. A.; Doan, R. A.; Steyer, A. M.; Nolan, M. F.; Möbius, W.; Monk, K. R.; Werner, H. B.; Emery, B.; Lyons, D. A.
10.1101/2025.01.10.632348 — neuroscience — Posted on 2025-01-10
3827 PARAS: high-accuracy machine-learning of substrate specificities in nonribosomal peptide synthetases
Terlouw, B. R.; Huang, C.; Meijer, D.; Cediel-Becerra, J. D. D.; Rothe, M. L.; Jenner, M.; Zhou, S.; Zhang, Y.; Fage, C. D.; Tsunematsu, Y.; van Wezel, G. P.; Robinson, S. L.; Alberti, F. L.; Alkhalaf, L. M.; Chevrette, M. G.; Challis, G.; Medema, M. H.
10.1101/2025.01.08.631717 — bioinformatics — Posted on 2025-01-10
3828 Local alkalinity enhancement using artificial substrates increases survivorship of early-stage coral recruits
Ruszczyk, M.; Rodriguez, S.; Tuen, M.; Rux, K.; Chandragiri, S.; Stickley, M.; Haus, B. K.; Baker, A. C.; Miller, M.; Suraneni, P.; Langdon, C.; Prakash, V. N.
10.1101/2025.01.07.631763 — ecology — Posted on 2025-01-10
3829 Exosomes derived from highly scalable and regenerative human progenitor cells promote functional improvement in a rat model of ischemic stroke
Lee, J.; Var, S. R.; Chen, D.; Natera-Rodriguez, D. E.; Hassanipour, M.; West, M. D.; Low, W. C.; Grande, A. W.; Larocca, D.
10.1101/2025.01.07.631793 — neuroscience — Posted on 2025-01-10
3838 Development of avian influenza A(H5) virus datasets for Nextclade enables rapid and accurate clade assignment
Ort, J. T.; Shepard, S. S.; Zolnoski, S. A.; Lam, T. T.- Y.; Davis, T.; Neher, R.; Moncla, L. H.
10.1101/2025.01.07.631789 — bioinformatics — Posted on 2025-01-10
3844 Diversity, connectivity and negative interactions define robust microbiome networks across land, stream, and sea
Kajihara, K. T.; Yuan, M.; Amend, A. S.; Cetraro, N.; Darcy, J. L.; Fraiola, K. M. S.; Frank, K. L.; McFall-Ngai, M.; Medeiros, M. C. I.; Nakayama, K. K.; Nelson, C. E.; Rollins, R. L.; Sparagon, W. J.; Swift, S. O. I.; Tefit, M. A.; Yew, J. Y.; Yogi, D.; Hynson, N. A.
10.1101/2025.01.07.631746 — ecology — Posted on 2025-01-10
3846 Spatiotemporal changes in soil properties predict plant health at continental scale
Wang, N.; Jiang, G.; Hou, Y.; Li, C.; Meng, Y.; Chen, P.; Zhang, Y.; Yang, T.; Wang, X.; Mei, X.; Pommier, T.; Banerjee, S.; Rillig, M.; Dini-Andreote, F.; Friman, V. P.; Xu, Y.; Jousset, A.; Shen, Q.; Wei, Z.
10.1101/2025.01.07.631818 — ecology — Posted on 2025-01-10
3848 A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques
Peres, A.; Upadhyay, A. A.; Klein, V. H.; Saha, S.; Rodriguez, O. L.; Vanwinkle, Z. M.; Granholm, L.; Karunakaran, K.; Lauer, W.; Lin, M. C.; Melton, T.; Metz, A.; Polak, P.; Raju, N.; Shields, K.; Schultze, S.; Ton, T.; Ericsen, A.; Lapp, S. A.; Smith, M.; Lees, W.; Watson, C. T.; Yaari, G.; Bosinger, S. E.
10.1101/2025.01.07.631319 — immunology — Posted on 2025-01-10
3849 An intranasal, NLC-delivered self-amplifying RNA vaccine establishes protective immunity against pre-pandemic H5N1 and H7N9 influenza
Ykema, M. R.; Davis, M. A.; Kasal, D. N.; Jennewein, M. F.; Lo, E.; Singh, J.; Beaver, S.; Cross, N.; Melief, E.; Reed, S.; Press, C.; Fusco, P.; Bakken, J.; Casper, C.; Hartwig, A. T.; Gerhardt, A.; Bowen, R. A.; Voigt, E. A.
10.1101/2025.01.07.631792 — immunology — Posted on 2025-01-10
3850 EPISeg: Automated segmentation of the spinal cord on echo planar images using open-access multi-center data
Banerjee, R.; Kaptan, M.; Tinnermann, A.; Khatibi, A.; Dabbagh, A.; Kündig, C. W.; Law, C. S. W.; Pfyffer, D.; Lythgoe, D. J.; Tsivaka, D.; Van De Ville, D.; Eippert, F.; Muhammad, F.; Glover, G. H.; David, G.; Haynes, G.; Haaker, J.; Brooks, J. C. W.; Finsterbusch, J.; Martucci, K. T.; Hemmerling, K. J.; Mobarak-Abadi, M.; Hoggarth, M. A.; Howard, M. A.; Bright, M. G.; Kinany, N.; Kowalczyk, O. S.; Freund, P.; Barry, R. L.; Mackey, S.; Vahdat, S.; Schading, S.; McMahon, S. B.; Parish, T.; Marchand-Pauvert, V.; Chen, Y.; Smith, Z. A.; Weber, K. A.; De Leener, B.; Cohen-Adad, J.
10.1101/2025.01.07.631402 — neuroscience — Posted on 2025-01-10
3851 Ustilaginoidea virens suppresses floral immunity through promoting GA biosynthesis by the effector SCRE9
Yu, S.; Zhang, S.; Zheng, X.; Li, X.; Wang, J.; Duan, G.; Qiu, S.; Zhao, D.; Nan, N.; Yu, Q.; Jiang, C.; Peng, Z.; Li, D.; Sun, W.
10.1101/2025.01.07.631775 — plant biology — Posted on 2025-01-10
3858 Ancient gene clusters initiate monoterpene indole alkaloid biosynthesis and C-3 stereochemistry inversion
Hwang, J.; Kirshner, J.; Deschenes, D. A. R.; Richardson, M. B.; Fleck, S. J.; Guo, J.; Perley, J. O.; Shahsavarani, M.; Garza-Garcia, J. J. O.; Seveck, A. D.; Doiron, S. S.; Mai, Z.; Silliphant, S. N.; Calhoun, L.; Gao, D.; Lian, J.; Deslongchamps, G.; Albert, V. A.; Qu, Y.
10.1101/2025.01.07.631695 — biochemistry — Posted on 2025-01-10
3859 NERINE reveals rare variant associations in gene networks across multiple phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease
Nazeen, S.; Wang, X.; Morrow, A.; Strom, R.; Ethier, E.; Ritter, D.; Henderson, A.; Afroz, J.; Stitziel, N. O.; Gupta, R. M.; Luk, K.; Studer, L.; Khurana, V.; Sunyaev, S. R.
10.1101/2025.01.07.631688 — genetics — Posted on 2025-01-10
3862 The secreted Nimrod NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila
Dolgikh, A.; Rommelaere, S.; Ghanem, A.; Petrignani, B.; Poidevin, M.; Kurant, E.; Lamaitre, B.
10.1101/2025.01.07.631694 — immunology — Posted on 2025-01-10
3863 Silica-mediated exacerbation of inflammatory arthritis: A novel murine model
Janssen, L. M. F. M. F.; de Ocampo, C.; Kono, D. H.; Ronsmans, S.; Ghosh, M.; Hoet, P. H. M.; Pollard, K. M.; Mayeux, J. M.
10.1101/2025.01.07.631488 — immunology — Posted on 2025-01-10
3864 Star-Shaped Glatiramer Acetate Mitigates Pulmonary Dysfunction and Brain Neurodegeneration in a Murine Model of Cryptococcus-Associated IRIS
Anwar, S.; Zhou, J.; Kowalski, L.; Saylor, J.; Shukla, D.; Boetel, K.; Song, Z.; Sharma, K.; Cheng, J.; Inoue, M.
10.1101/2025.01.07.631707 — immunology — Posted on 2025-01-10
3866 Severe Fe deficiency promotes hypoxia inducible responses in Arabidopsis thaliana
Telara, Y.; Maghrebi, M.; Lavilla, M.; La Monaca, N.; Ambrogini, G.; Sbrana, A.; Delucchi, S.; Perata, P.; Vigani, G.; Giuntoli, B.
10.1101/2025.01.07.631690 — plant biology — Posted on 2025-01-10
3868 Dynamic global acetylation remodeling during the yeast heat shock response
Hardman-Kavanaugh, R. E.; Storey, A. J.; Stuecker, T. N.; Hood, S. E.; Barrett-Wilt, G. A.; Krishnamurthi, V. R.; Wang, Y.; Byrum, S. D.; Mackintosh, S. G.; Edmondson, R. D.; Wahls, W. P.; Tackett, A. J.; Lewis, J. A.
10.1101/2025.01.10.632339 — genomics — Posted on 2025-01-10
3869 ERGA-BGE genome of the Spanish Moon Moth Graellsia isabellae Graells, 1849: a nocturnal lepidopteran protected by the Habitats Directive
Vila, M.; Mari-Mena, N.; Vila, R.; Riesgo, A.; Garcia-Souto, D.; Lopez-Vaamonde, C.; Bohne, A.; Monteiro, R.; Marcussen, T.; Oomen, R.; Struck, T. H.; Gut, M.; Aguilera, L.; Camara Ferreira, F.; Cruz Rodriguez, F.; Gomez-Garrido, J.; Alioto, T. S.; Bortoluzzi, C.
10.1101/2025.01.08.631683 — genomics — Posted on 2025-01-10
3870 Dipeptidase 1 is a functional receptor for coronavirus PHEV
Dufloo, J.; Fernandez, I.; Arbabian, A.; Haouz, A.; Gimenez-Lirola, L. G.; Rey, F. A.; Sanjuan, R.
10.1101/2025.01.09.632101 — microbiology — Posted on 2025-01-10
3871 Comprehensive Infectome Analysis Reveals Diverse Infectious Agents with Zoonotic Potential in Wildlife
Hou, X.; Wang, J.; Wang, D.-X.; Chen, Y.; Li, X.-X.; Wu, W.-C.; Le, S.-J.; Mei, S.-Q.; Liu, H.-L.; Feng, Y.; Yang, L.-F.; Shi, P.-B.; Ren, Z.-R.; Yang, L.; He, H.-J.; Song, W.-J.; Chen, J.; Zhu, M.-M.; Jiang, Z.-W.; Li, X.-M.; Guo, D.; Holmes, E. C.; Deng, Z.-Q.; Shi, M.; Su, S.
10.1101/2025.01.09.632079 — microbiology — Posted on 2025-01-10
3873 Alpha and beta desynchronization during consolidation of newly learned words
Zappa, A.; Leon-Cabrera, P.; Ramos-Escobar, N.; Laine, M.; Rodriguez-Fornells, A.; Francois, C.
10.1101/2025.01.09.632010 — neuroscience — Posted on 2025-01-10
3874 Differential effects of dopamine and serotonin on reward and punishment processes in humans: A systematic review and meta-analysis
Mkrtchian, A.; Qiu, Z.; Abir, Y.; Erdmann, T.; Dercon, Q.; Sedlinska, T.; Browning, M.; Costello, H.; Huys, Q. J. M.
10.1101/2025.01.08.631868 — neuroscience — Posted on 2025-01-10
3877 Predicting Personalised Therapeutic Combinations in Non-Small Cell Lung Cancer Using In Silico Modelling
Clarke, M. A.; Barker, C. G.; Nicholls, A.; Handler, M. P.; Pickard, L.; Shah, A.; Walter, D.; De Braekeleer, E.; Banerji, U.; Choudhary, J.; Ahmad, S.; McDermott, U.; Hannon, G. J.; Fisher, J.
10.1101/2025.01.07.631497 — cancer biology — Posted on 2025-01-10
3880 ERGA-BGE genome of Erebia palarica Chapman, 1905: a montane butterfly endemic to North-West Iberia
Vila, M.; Torrado-Blanco, L.; Ryrholm, N.; Romero-Pedreira, D.; Conejero, M.; Bohne, A.; Monteiro, R.; Marcussen, T.; Oomen, R.; Struck, T. H.; Aguilera, L.; Gut, M.; Camara Ferreira, F.; Cruz Rodriguez, F.; Gomez-Garrido, J.; Alioto, T. S.; Bortoluzzi, C.
10.1101/2025.01.08.631636 — genomics — Posted on 2025-01-10
3881 Niacin protects against vascular calcification via enhanced SIRT1 and SIRT6 signaling and promoted VSMC autophagy
Chen, S.-l.; Kong, C.-H.; Wu, L.; Sun, Y.; Jiang, X.-M.; Shi, Y.; Wang, F.; Wang, D.-C.; Gu, Y.; Zhou, W.; Luo, J.; Chao, Y.
10.1101/2025.01.07.631823 — cell biology — Posted on 2025-01-10
3882 Massive culture-based approach for the screening of AmpC-, ESBL- and carbapenemase producers from complex samples
Taddeucci-Rocha, G.; Costa, V. d. O.; Martins da Silva, S. V.; Goncalves, J. B.; Zambao da Silva, N. C.; Garnica, M.; Picao, R. C.
10.1101/2025.01.06.631451 — microbiology — Posted on 2025-01-10
3883 Cyanochelin B: A siderophore produced by cyanobacterium Leptolyngbya sp. NIES-3755 with photolytic properties that negate iron monopolization in the UV-light
Falcao, B. P.; Di Matteo, V.; Hrouzek, P.; Stenclova, L.; Urajova, P.; Mares, J.; Kuta, J.; Yerena, J. A. M.; Zapomelova, E.; Esposito, G.; mangoni, A.; Costantino, V.; Galica, T.
10.1101/2025.01.08.631963 — microbiology — Posted on 2025-01-10
3884 A comparative evaluation of CRISPR-Cas9 allele editing systems in Candida auris: challenging research in a challenging bug
Carolus, H.; Sofras, D.; Subotic, A.; Lobo Romero, C.; Ennis, C. L.; Hernday, A. D.; Nobile, C. J.; Ryback, J.; Van Dijck, P.
10.1101/2025.01.09.632232 — microbiology — Posted on 2025-01-10
3886 Mechanical impact on neural stem cell lineage decisions in human brain organoids
Falk, S.; Lampersperger, H.; Tranchina, M.; Meth, B.; Han, D.; Nayebzadeh, N.; Reiter, N.; Kuth, S.; Lorke, M.; Boccaccini, A. R.; Budday, S.; Karow, M.
10.1101/2025.01.08.631895 — neuroscience — Posted on 2025-01-10
3887 The subunit 3 of the SUPERKILLER (SKI) complex mediates miR172-directed cleavage of Nodule Number Control 1 (NNC1) to modulate nodulation in Medicago truncatula
Traubenik, S.; Reynoso, M. A.; Sanchez-Rodriguez, F.; Yacullo, M.; Christ, A.; Hummel, M.; Blein, T.; Crespi, M.; Bailey-Serres, J.; Blanco, F. A.; Zanetti, M. E.
10.1101/2025.01.06.631520 — plant biology — Posted on 2025-01-10
3888 ATR and PKMYT1 inhibition re-sensitize a subset of TNBC patient-derived models to carboplatin inducing mitotic catastrophe
Guay, J.; Kuasne, H.; Chabot, C.; Bozek, K.; Buchanan, M.; Majedi, Y.; Aguilar-Mahecha, A.; Bareke, E.; Kong, T.; Yang, K.; Elebute, O.; Guo, R.; Monast, A.; Morin, G.; Huang, S.; Park, M.; Basik, M.
10.1101/2025.01.07.629892 — cancer biology — Posted on 2025-01-10
3889 Anillin directly cross-links microtubules with filamentous actin
Bareja, I.; Kucera, O.; Petitjean, I. I.; Sabo, J.; Braun, M.; Lansky, Z.; Koenderink, G.; Dogterom, M.
10.1101/2025.01.07.631698 — biophysics — Posted on 2025-01-10
3891 Monkeypox virus spreads from cell-to-cell and leads to neuronal death in human neural organoids
Schultz-Pernice, I.; Fahmi, A.; Britto, F.; Liniger, M.; Chiu, Y.-C.; David, T.; Oliveira Esteves, B. I.; Golomingi, A.; Zumkehr, B.; Gerber, M.; Jandrasits, D.; Zuest, R.; Steiner, S.; Wotzkow, C.; Blank, F.; Engler, O. B.; Summerfield, A.; Ruggli, N.; Baud, D.; Alves, M. P.
10.1101/2023.09.19.558432 — microbiology — Posted on 2025-01-10
3892 Stick together: Isolation and characterization of exopolysaccharide producing bacteria from degraded permafrost soils
Waqas, M.; Zelenkova, S.; Vogel, C.; Ruhmann, B.; Varsadiya, M.; Liebmann, P.; Wang, H.; Shibistova, O.; Urich, T.; Guggenberger, G.; Barta, J.
10.1101/2024.12.28.630587 — microbiology — Posted on 2025-01-10
3893 WITHDRAWN: Gammaherpesvirus infection alters transfer RNA splicing and triggers tRNA cleavage
Manning, A. C.; Bashir, M. M.; Jimenez, A. C.; Upton, H. E.; Collins, K.; Lowe, T. M.; Tucker, J. M.
10.1101/2024.02.16.580780 — microbiology — Posted on 2025-01-10
3894 TOGGLE identifies fate and function process within a single type of mature cell through single-cell transcriptomics
Chen, J.; Jiang, E.; Chen, Z.; Liu, K.; Sun, T.; Nong, Y.; Yuan, T.; Daga, P.; Dai, C. C.; Yan, Y.; Ge, J.; Wu, H.; Yang, T.; Wang, S.; Su, Z.; Li, C.; Li, Y.; Yang, K.; Singhal, R. A.; Carll, A. P.
10.1101/2025.01.01.631041 — bioinformatics — Posted on 2025-01-10
3900 Ultra-sensitivity metaproteomics redefines the gut dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases.
Xian, F.; Brenek, M.; Krisp, C.; Aguanno, D.; Urbauer, E.; Srikumar, T.; Ravi Kumar, R. K.; Liu, Q.; Barry, A. M.; Ma, B.; Krieger, J.; Haller, D.; Schmidt, M.; Gomez Varela, D.
10.1101/2024.04.22.590295 — microbiology — Posted on 2025-01-10
3906 Cardiolipin deficiency disrupts CoQ-complex III interface in steatohepatitis
Brothwell, M. J.; Cao, G.; Maschek, J. A.; Poss, A. M.; Peterlin, A. D.; Wang, L.; Baker, T. B.; Shahtout, J. L.; Siripoksup, P.; Pearce, Q. J.; Johnson, J. M.; Finger, F. M.; Prola, A.; Pellizzari, S. A.; Hale, G. L.; Manuel, A. M.; Watanabe, S.; Miranda, E. R.; Affolter, K. E.; Tippetts, T. S.; Nikolova, L. S.; Choi, R. H.; Decker, S. T.; Patil, M.; Catrow, J. L.; Holland, W. L.; Nowinski, S. M.; Lark, D. S.; Fisher-Wellman, K. H.; Mimche, P. N.; Evason, K. J.; Cox, J. E.; Summers, S. A.; Gerhart-Hines, Z.; Funai, K.
10.1101/2024.10.10.617517 — biochemistry — Posted on 2025-01-10
3907 Generation and Characterization of a Knockout Mouse of an Enhancer of EBF3
Hurtado, E. C.; Wotton, J. M.; Gulka, A.; Burke, C.; Ng, J. K.; Bah, I.; Manuel, J.; Heins, H.; Murray, S. A.; Gorkin, D. U.; White, J. K.; Peterson, K. A.; Turner, T. N.
10.1101/2025.01.09.631762 — genetics — Posted on 2025-01-10
3909 Neural plate pre-patterning enables specification of intermediate neural progenitors in the spinal cord
Nandagopal, S.; Cha, A.; Jia, B. Z.; Liao, H.; Comenho, C.; Lahav, G.; Wagner, D. E.; Tsai, T. Y.-C.; Megason, S. G.
10.1101/2025.01.09.632276 — developmental biology — Posted on 2025-01-10
3910 Absolute Quantification of Lysosomal Proteins by Multiple Reaction Monitoring Mass Spectrometry and QconCAT Protein Standards
Mosen, P. R.; Moharana, B.; Fajardo-Callejon, S.; Kaade, E.; Roesel, N.; Omidi, M.; Sakson, R.; Ruppert, T.; Pohl, S.; Gieselmann, V.; Winter, D.
10.1101/2025.01.09.632238 — molecular biology — Posted on 2025-01-10
3913 Susceptibility of bovine respiratory and mammary epithelial cells to avian and mammalian derived clade 2.3.4.4b H5N1 highly pathogenic avian influenza viruses
Meliopoulos, V. A.; Cherry, S.; Smith, M.; Sharp, B.; Brigleb, P. H.; Roubidoux, E. K.; Livingston, B.; Morris, D. R.; Ripperger, T.; Baker, P.; Gragg, S.; Dimitrov, K. M.; Langel, S.; Schultz-Cherry, S.
10.1101/2025.01.09.632235 — microbiology — Posted on 2025-01-10
3914 Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters
da Silva Antunes, R.; Fajardo-Rosas, V.; Yu, E. D.; Galvez, R. I.; Abawi, A.; Escarrega, E. A.; Martinez-Perez, A.; Johansson, E.; Goodwin, B.; Frazier, A.; Dan, J. M.; Crotty, S.; Seumois, G.; Weiskopf, D.; Vijayanand, P.; Sette, A.
10.1101/2025.01.08.631842 — immunology — Posted on 2025-01-10
3916 C12ORF57: a novel principal regulator of synaptic AMPA currents and excitatory neuronal homeostasis
Jiang, R.; Chouchane, M.; Moey, C.; Bunt, J.; Li, J.; Allkuraya, F.; Alobeid, E.; Richards, L.; Ullian, E.; Sherr, E.
10.1101/2025.01.08.632037 — neuroscience — Posted on 2025-01-10
3917 Predictive acoustical processing in human cortical layers
Faes, L. K.; Zulfiqar, I.; Vizioli, L.; Yu, Z.; Wu, Y.-H.; Shin, J.; Cloos, M. A.; Auksztulewicz, R.; Melloni, L.; Uludag, K.; Yacoub, E.; De Martino, F.
10.1101/2025.01.09.632099 — neuroscience — Posted on 2025-01-10
3921 Deficiency of Shank3 in the Nucleus Accumbens Reveals a Loss of Social-Specific Motivation
Folkes, O. M.; Donahue, M.; Wang, S. E.; Oo, N. X.; Wang, X.; Negron-Moreno, P. N.; Jiang, Y.-H.
10.1101/2025.01.08.631742 — neuroscience — Posted on 2025-01-10
3922 Global dissection of the impact of Alzheimer's disease on brain architecture and behavior: High resolution MRH resolves robust regional effects
Johnson, G. A.; Tian, Y.; Hornburg, K. J.; Qi, Y.; White, L. E.; Killmar, J.; Kaczorowski, C.; Ashbrook, D. G.; Williams, R. W.
10.1101/2025.01.08.632011 — neuroscience — Posted on 2025-01-10
3923 Decoding the Molecular Language of Proteins with Evolla
Zhou, X.; Han, C.; Zhang, Y.; Su, J.; Zhuang, K.; Jiang, S.; Yuan, Z.; Zheng, W.; Dai, F.; Zhou, Y.; Tao, Y.; Wu, D.; Yuan, F.
10.1101/2025.01.05.630192 — bioinformatics — Posted on 2025-01-09
3924 Modeling the human limb skeletal development using human pluripotent stem cell-derived skeletal assembloid
Takao, T.; Osone, T.; Sato, K.; Yamada, D.; Fujisawa, Y.; Hagiwara, M.; Nakata, E.; Ozaki, T.; Toguchida, J.; Takarada, T.
10.1101/2025.01.09.631479 — bioengineering — Posted on 2025-01-10
3925 Structural insights into mechanisms of zinc scavenging by the Candida albicans zincophore Pra1
Syrjanen, J. L.; Nore, A.; Roselletti, E.; Chakraborty, T.; Perera, R. L.; Wilson, D.
10.1101/2025.01.09.632233 — biochemistry — Posted on 2025-01-09
3927 Ag+-regulated aptamers to thrombin
Alieva, R.; Sokolova, S.; Oleynikov, I.; Novikov, R.; Zatsepin, T.; Aralov, A.; Zavyalova, E.
10.1101/2025.01.09.632085 — biochemistry — Posted on 2025-01-09
3928 Structural and functional characterization of integrin a5-targeting antibodies for anti-angiogenic therapy
Nguyen, A.; Heim, J. B.; Cordara, G.; Chan, M. C.; Johannesen, H.; Charlesworth, C.; Li, M.; Azumaya, C. M.; Madden, B.; Krengel, U.; Meves, A.; Campbell, M. G.
10.1101/2025.01.08.631572 — biochemistry — Posted on 2025-01-09
3929 AMPylation regulates PLD3 processing.
Hoffmann, L.; Eckl, E.-M.; Berouti, M.; Pries, M.; Koller, A.; Guhl, C.; Hellmich, U. A.; Hornung, V.; Xiang, W.; Jae, L. T.; Kielkowski, P.
10.1101/2025.01.09.632087 — biochemistry — Posted on 2025-01-09
3930 The complete {lambda}-carrageenan depolymerization cascade from a marine Pseudoalteromonad revealed by structural analysis of the enzymes.
Vickers, C. J.; Hettle, A. G.; Hobbs, J. K.; Shapiro-Ward, S.; Pluvinage, B.; Medley, B. J.; McGuire, B. E.; Mihalynuk, L.; Nitin, N.; Zandberg, W. F.; Boraston, A. B.
10.1101/2025.01.09.632246 — biochemistry — Posted on 2025-01-09
3931 Bacteroidales T6SS minor Hcp subunits form heteromers recognising effectors
San-Miguel, S. G.; Al-Ammari, M. K. S.; Kowalska, A.; Sauer, U.; Batista, P. R.; Sandblad, L.; Uhlin, B. E.; Cisneros, D. A.
10.1101/2025.01.09.632221 — biochemistry — Posted on 2025-01-10
3932 The N-terminal order-disorder transition is a critical determinant for a metamorphosis of IscU
Na, J.; Heo, J.; Jeong, M.; Ji, S.; Ko, Y. H.; Shafiei, A.; Baldir, N.; DeMirci, H.; Yu, W.; Kim, J. H.
10.1101/2025.01.09.632086 — biochemistry — Posted on 2025-01-10
3936 Aggregation of HAPLN2, a component of the perinodal extracellular matrix, is a hallmark of physiological brain aging in mice
Watanabe, A.; Hirayama, S.; Kominato, I.; Marchese, S.; Esposito, P.; Metodieva, V.; Kameda, H.; Sano, T.; Takatori, S.; Takao, M.; Koike, M.; Varela, J. A.; Tomita, T.; Murata, S.
10.1101/2025.01.09.632092 — biochemistry — Posted on 2025-01-10
3937 N6-methyladenosine and the NEXT complex direct Xist RNA turnover and X inactivation dynamics
Wei, G.; Coker, H.; Rodermund, L.; Almeida, M.; Roach, H. L.; Nesterova, T. B.; Brockdorff, N.
10.1101/2025.01.09.632176 — biochemistry — Posted on 2025-01-10
3939 rbfox1 loss of function in zebrafish leads to dysregulation in bdnf/trkb2 and pac1a expression resulting in HPI axis hyperactivation, altered stress response and allostatic overload
Leggieri, A.; Judit Garcia-Gonzalez, J.; Hosseinian, S.; Ashdown, P.; Anagianni, S.; Wang, X.; Havelange, W.; Fernandez-Castillo, N.; Cormand, B.; Brennan, C. H.
10.1101/2024.10.09.616976 — genetics — Posted on 2025-01-10
3941 Rigorous process for isolation of gut-derived extracellular vesicles and the effect on latent HIV
Anyanwu, N. C. J.; Premadasa, L. S.; Naushad, W.; Okeoma, B. C.; Mohan, M.; Okeoma, C. M.
10.1101/2025.01.09.632234 — molecular biology — Posted on 2025-01-09
3943 SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agents
Iimori, Y.; Morita, T.; Masuda, T.; Kitajima, S.; Kono, N.; Kageyama, S.; Galipon, J.; Sasaki, A. T.; Kanai, A.
10.1101/2025.01.08.632070 — molecular biology — Posted on 2025-01-09
3945 METTL3 Aggravates Intimal Hyperplasia by Facilitating the m6A-YTHDC1-dependent SGK1 Gene Transcription
huang, J.; Feng, Q.; Dong, Z.; Li, Z.; Liu, Y.; Xu, R.; Liu, Z.; Ding, Q.; Yang, X.; Yu, F.; Jia, Y.; Zhou, Y.; Kong, W.; Hao, T.; Fu, Y.
10.1101/2025.01.09.632275 — molecular biology — Posted on 2025-01-09
3946 The RING Finger E3 Ligase RNF25 Protects DNA Replication Forks Independently of its Canonical Roles in Ubiquitin Signaling
Chiou, L. F.; Jayaprakash, D.; Droby, G. N.; Zhang, X.; Yang, Y.; Mills, C. A.; Webb, T. S.; Barker, N. K.; Wu, D.; Herring, L. E.; Bowser, J.; Vaziri, C.
10.1101/2025.01.09.632184 — molecular biology — Posted on 2025-01-09
3948 UFMylation promotes orthoflavivirus infectious particle production
Schmidt, H. M.; Sorensen, G. C.; Lanahan, M. R.; Grabowski, J.; Park, M.; Horner, S. M.
10.1101/2025.01.09.632082 — microbiology — Posted on 2025-01-09
3950 Metatranscriptomics sheds light on 'who is doing what' in the coral Porites lutea
Tandon, K.; Hu, J.; Ricci, F.; Blackall, L.; Medina, M.; Kuhl, M.; Verbruggen, H.
10.1101/2025.01.09.632055 — microbiology — Posted on 2025-01-09
3955 Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer's disease, and cognitive resilience
Tosoni, G.; Ayyildiz, D.; Penning, A.; Snoeck, S.; Santiago-Mujika, E.; Ruiz Ormaechea, O.; Lee, H.; Poovathingal, S. K.; Davie, K.; Bryois, J.; Macnair, W.; Anink, J.; De Vries, L.; Verhaagen, J.; Aronica, E.; Thuret, S.; Basak, O.; Roybon, L.; Fitzsimons, C. P.; Lucassen, P. J.; Salta, E.
10.1101/2025.01.08.631686 — neuroscience — Posted on 2025-01-10
3956 Integration of sensory and fear memories in the rat medial temporal lobe
Wong, F. S.; Thomas, A. B.; Killcross, S.; Laurent, V.; Westbrook, R. F.; Holmes, N. M.
10.1101/2024.07.31.605652 — neuroscience — Posted on 2025-01-10
3957 Design of novel synthetic promoters to tune gene expression in T cells
Bonfa, G.; Martino, G.; Sellitto, A.; Rinaldi, A.; Tedeschi, F.; Caliendo, F.; Melchiorri, L.; Perna, D.; Starkey, F.; Nikolados, E.; Menolascina, F.; Siciliano, V.
10.1101/2025.01.09.632034 — synthetic biology — Posted on 2025-01-09
3960 Identification and Functional Characterization of Regulatory Variants in DPP9 Associated with COVID-19 Severity
Farah, G.; Torres, M.; Henches, L.; Aschard, H.; Ghosn, J.; Duval, X.; Milieu Interieur Consortium, ; French COVID Cohort Study Group, ; Rihet, P.; Spicuglia, S.; Marquet, S.
10.1101/2025.01.07.631679 — genetics — Posted on 2025-01-09
3961 habtools: an R package to calculate 3D metrics for surfaces and objects
Schiettekatte, N. M.; Asbury, M.; Chen, G.-Y.; Dornelas, M.; Reichert, J.; Torres-Pulliza, D.; Zawada, K. J.; Madin, J. S.
10.1101/2024.09.19.613985 — ecology — Posted on 2025-01-09
3963 APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence
Xie, J.; Chen, D. G.; Chour, W.; Ng, R. H.; Zhang, R.; Yuan, D.; Choi, J.; McKasson, M.; Troisch, P.; Smith, B.; Jones, L.; Webster, A.; Rasheed, Y.; Li, S.; Edmark, R.; Hong, S.; Murray, K. M.; Logue, J. K.; Franko, N. M.; Lausted, C. G.; Piening, B.; Algren, H.; Wallick, J.; Magis, A. T.; Watanabe, K.; Mease, P.; Greenberg, P. D.; Chu, H.; Goldman, J. D.; Su, Y.; Heath, J. R.
10.1101/2025.01.08.631993 — immunology — Posted on 2025-01-09
3964 DeMBA: a developmental atlas for navigating the mouse brain in space and time
Carey, H.; Kleven, H.; Ovsthus, M.; Yates, S. C.; Csucs, G.; Puchades, M. A.; McMullan, S.; Bjaalie, J. G.; Leergaard, T. B.; Bjerke, I. E.
10.1101/2024.06.14.598876 — neuroscience — Posted on 2025-01-09
3965 Serotonergic mediation of orienting and defensive responses in zebrafish
do Nascimento, B. G.; Rodrigues, J. R.; Silva, M. C. R.; Dutra Costa, B. P.; Silva, M. L.; Pyterson, M. P.; Silva, H. T. L.; Bruce de Souza, L. V. X.; de Siqueira-Silva, D. H.; Maximino, C.
10.1101/2023.11.24.568601 — neuroscience — Posted on 2025-01-09
3966 Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells
Kowar, A.; Becker, J. P.; Del Pizzo, R.; Tang, Z.; Champagne, J.; Koerner, P.-R.; Navarro, J. M.; Tilghman, F. M.; Sakeer, H.; Riemer, A. B.; Agami, R.; Loayza-Puch, F.
10.1101/2025.01.08.631915 — cancer biology — Posted on 2025-01-09
3967 Impaired oxidative phosphorylation drives primary tumor escape and metastasis
Arner, E. N.; Jennings, E. Q.; Crooks, D. R.; Ricketts, C. J.; Wolf, M. M.; Cottam, M. A.; Fisher-Gupta, E. L.; Lang, M.; Maio, N.; Shibata, Y.; Krystofiak, E. N.; Vlach, L. M.; Hatem, Z.; Blatt, A. M.; Heintzman, D. R.; Sewell, A. E.; Hathaway, E. S.; Steiner, K. K.; Ye, X.; Schaefer, S.; Bacigalupa, Z. A.; Linehan, M.; Beckermann, K. E.; Mason, F. M.; Idrees, K.; Rathmell, W. K.; Rathmell, J. C.
10.1101/2025.01.08.631936 — cancer biology — Posted on 2025-01-09
3968 An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations
Loberg, M. A.; Xu, G. J.; Chen, S.-C.; Chen, H.-C.; Wahoski, C. C.; Caroland, K. P.; Tigue, M. L.; Hartmann, H. A.; Gallant, J.-N.; Phifer, C. J.; Ocampo, A.; Wang, D. K.; Fankhauser, R. G.; Karunakaran, K. A.; Wu, C.-C.; Tarabichi, M.; Shaddy, S. M.; Netterville, J. L.; Rohde, S. L.; Solorzano, C. C.; Bischoff, L. A.; Baregamian, N.; Murphy, B. A.; Choe, J. H.; Wang, J. R.; Huang, E. C.; Sheng, Q.; Kagohara, L. T.; Jaffee, E. M.; Belcher, R. H.; Lau, K.; Ye, F.; Lee, E.; Weiss, V. L.
10.1101/2025.01.08.631962 — cancer biology — Posted on 2025-01-09
3969 Context-dependent translation inhibition as a novel oncology therapeutic modality
Diamond, P. D.; Sauer, P. V.; Holm, M.; Swanson-Swett, C. J.; Ferguson, L.; Bratset, N. M.; Wienker, G. W.; Sim, J. S.; Adams, H. K.; Kenner, L.; Meyers, M.; Gygi, D.; Könst, Z. A.; Bahmanyar, S. S.; Hamann, L. G.; Schuller, A. P.
10.1101/2025.01.09.632223 — cancer biology — Posted on 2025-01-09
3970 JNK pathway suppression drives resistance to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer
Alexandrou, S.; Lee, C. S.; Fernandez, K. J.; Wiharja, C. E.; Eshraghi, L.; Reeves, J.; Reed, D. A.; Phan, Z.; Portman, N.; Milioli, H. H.; Nikolic, I.; Cadell, A. L.; Croucher, D. R.; Simpson, K. J.; Lim, E.; Hickey, T. E.; Millar, E. K. A.; Alves, C. L.; Ditzel, H. J.; Caldon, C. E.
10.1101/2025.01.08.631992 — cancer biology — Posted on 2025-01-09
3974 Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish
Eski, S. E.; Mi, J.; Pozo-Morales, M.; Hovhannisyan, G. G.; Perazzolo, C.; Manco, R.; Ez-Zammoury, I.; Barbhaya, D.; Lefort, A.; Libert, F.; Marini, F.; Gurzov, E. N.; Andersson, O.; Singh, S. P.
10.1101/2025.01.09.629100 — developmental biology — Posted on 2025-01-09
3976 Foxi2 and Sox3 are master regulators controlling ectoderm germ layer specification
Hendrickson, C.; Blitz, I. L.; Hussein, A.; Paraiso, K. D.; Cho, J.; Klymkowsky, M. W.; Kofron, M. J.; Cho, K. W. Y.
10.1101/2025.01.09.632114 — developmental biology — Posted on 2025-01-09
3979 CONSERVED NUCLEAR MORPHOLOGY IDENTIFIES FUNCTIONAL RADIAL GLIA NEURAL PROGENITORS
Soriano, J. P.; Borau, C.; Sortino, R.; Garma, L.; Ortega, J. A.; Asin, J.; Alcantara, S.
10.1101/2025.01.09.632137 — developmental biology — Posted on 2025-01-09
3980 Distinct origin and fate for fetal hematopoietic progenitors
Soares-da-Silva, F.; Nogueira, G.; Mailhe, M.-P.; Freyer, L.; Perkins, A.; Hatano, S.; Yoshikai, Y.; Pereira, P.; Bandeira, A.; ELSAID, R.; Gomez-Perdiguero, E.; Cumano, A.
10.1101/2025.01.08.631951 — developmental biology — Posted on 2025-01-09
3981 microRNA-210 enhances cell survival and paracrine potential for cardiac cell therapy while targeting mitophagy.
Alonaizan, R.; Purnama, U.; Malandraki-Miller, S.; Gunadasa-Rohling, M.; Lewis, A.; Smart, N.; Carr, C.
10.1101/2025.01.09.632206 — developmental biology — Posted on 2025-01-09
3984 Individual-specific strategies inform category learning
Collina, J.; Erdil, G.; Xia, M.; Angeloni, C. F.; Wood, K. C.; Sheth, J.; Kording, K. P.; Cohen, Y.; Geffen, M. N.
10.1101/2024.09.26.615062 — neuroscience — Posted on 2025-01-09
3985 Revealing hidden knowledge in amnestic mice
Santi, A.; Moore, S.; Fogelson, K. A.; Wang, A.; Lawlor, J.; Amato, J.; Burke, K.; Lauer, A. M.; Kuchibhotla, K. V.
10.1101/2025.01.09.632026 — neuroscience — Posted on 2025-01-09
3986 Age-dependent alterations in the head-direction signal in a rat model of Fragile X Syndrome
Moore, N.; Duszkiewicz, A. J.; Asiminas, A.; Dudchenko, P. A.; Peyrache, A.; Wood, E. R.
10.1101/2025.01.09.632139 — neuroscience — Posted on 2025-01-09
3987 The STAT3-VDAC1 Axis Modulates Mitochondrial Function and Plays a Critical Role in the Survival of Acute Myeloid Leukemia Cells
Gil, K. B.; Borg, J.; Moreira Pereira, R.; Inguva-Sheth, A.; Araujo, G.; Rahkola, J.; Showers, W.; Grier, A.; D'Alessandro, A.; Smith, C.; McMahon, C.; Pollyea, D. A.; Gillen, A. E.; Amaya, M. L.
10.1101/2024.06.24.600435 — cancer biology — Posted on 2025-01-09
3989 A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification
Wiegering, A.; Anselme, I.; Brunetti, L.; Metayer-Derout, L.; Calderon, D.; Thomas, S.; Nedelec, S.; Eschstruth, A.; Serpieri, V.; catala, m.; Antoniewski, C.; Schneider-Maunoury, S.; STEDMAN, A.
10.1101/2024.02.28.582477 — developmental biology — Posted on 2025-01-09
3991 N6-methyladenosine in DNA promotes genome stability
Conti, B.; Novikov, L.; Tong, D.; Xiang, Q.; Nguyen, C.; Vigil, S.; McLellan, T. J.; De La Cruz, N.; Veettil, R. T.; Pradhan, P.; Sahasrabudhe, P.; Arroyo, J. D.; Shang, L.; Sabari, B. R.; Shields, D. J.; Oppikofer, M.
10.1101/2024.07.20.604187 — molecular biology — Posted on 2025-01-09
3993 Adaptation, not prediction, drives neuronal spiking responses in mammalian sensory cortex
Westerberg, J. A.; Xiong, Y. S.; Nejat, H.; Sennesh, E.; Durand, S.; Hardcastle, B.; Cabasco, H.; Belski, H.; Bawany, A.; Gillis, R.; Loeffler, H.; Peene, C. R.; Han, W.; Nguyen, K.; Ha, V.; Johnson, T.; Grasso, C.; Young, A.; Swapp, J.; Ouellette, B.; Caldejon, S.; Williford, A.; Groblewski, P. A.; Olsen, S. R.; Kiselycznyk, C.; Lecoq, J. A.; Maier, A.; Bastos, A. M.
10.1101/2024.10.02.616378 — neuroscience — Posted on 2025-01-09
3994 The blast effector Pwl2 is a virulence factor that modifies the cellular localisation of host protein HIPP43 to suppress immunity.
Were, V.; Yan, X.; Foster, A.; Sklenar, J.; Langner, T.; Gentle, A.; Sahu, N.; Bentham, A.; Zdrzałek, R.; Ryder, L.; Kaimenyi, D.; Gomez De La Cruz, D.; Petit-Houdenot, Y.; Eseola, A. B.; Smoker, M.; Bautista, M. J.; Ma, W.; Kourelis, J.; Maclean, D.; Banfield, M. J.; Kamoun, S.; Menke, F. L. H.; Moscou, M. J.; Talbot, N. J.
10.1101/2024.01.20.576406 — plant biology — Posted on 2025-01-09
3996 Lipid Packing Defects are Necessary and Sufficient for Membrane Binding of alpha-Synuclein
Johnson, D. H.; Kou, O. H.; White, J. M.; Ramirez, S. Y.; Margaritakis, A.; Chung, P. J.; Jaeger, V. W.; Zeno, W. F.
10.1101/2024.11.14.623669 — biophysics — Posted on 2025-01-09
4000 Migratory dermal gamma delta T cells determine the balance between lung immunity and tissue damage during Nippostrongylus brasiliensis infection
Papotto, P. H.; Parkinson, J. E.; Chan, B. H. K.; Lin, I.-H.; Baldwin, G. E.; Denny, F.; Zhang, L.; Dodd, R.; Pearson, S. T.; Fischhaber, N.; Konkel, J. E.; Withers, D. R.; Hepworth, M. R.; Allen, J. E.
10.1101/2025.01.07.631663 — immunology — Posted on 2025-01-09
4005 A biologically plausible decision-making model based on interacting neural populations
Baspinar, E.; Cecchini, G.; DePass, M.; Andujar, M.; Pani, P.; Ferraina, S.; Moreno-Bote, R.; Cos, I.; Destexhe, A.
10.1101/2023.02.28.530384 — neuroscience — Posted on 2025-01-09
4006 Pelagic ecosystem responses to changes in seawater conditions during the Middle Pleistocene Transition in the Eastern Mediterranean
Agiadi, K.; Vasiliev, I.; Vite, A.; Zarkogiannis, S.; Fuster-Alonso, A.; Mestre-Tomas, J.; Koskeridou, E.; Quillevere, F.
10.1101/2024.12.28.630586 — systems biology — Posted on 2025-01-09
4007 Pregnancy and postpartum dynamics revealed by millions of lab tests
Bar, A.; Moran, R.; Mayo, A.; Mendelson Cohen, N.; Korem Kohanim, Y.; Toledano, Y.; Alon, U.
10.1101/2023.05.11.540359 — physiology — Posted on 2025-01-09
4010 Tricuspid valve leaflet remodeling in sheep with biventricular heart failure: A comparison between leaflets
Kostelnik, C. J.; Meador, W. D.; Lin, C.-Y.; Mathur, M.; Malinowski, M.; Jazwiec, T.; Malinowska, Z.; Piekarska, M. L.; Gaweda, B.; Timek, T. A.; Rausch, M. K.
10.1101/2024.09.16.613284 — bioengineering — Posted on 2025-01-09
4013 More dominant baboons have less and lower quality sleep
Fele, M.; Christensen, C.; Bracken, A. M.; O'Riain, J.; Lurgi, M.; Papadopoulou, M.; Fuertbauer, I.; King, A. J.
10.1101/2025.01.06.629345 — animal behavior and cognition — Posted on 2025-01-09
4019 Multi-modal refinement of the human heart atlas during the first gestational trimester
De Bono, C.; Xu, Y.; Kausar, S.; Herbane, M.; Humbert, C.; Rafatov, S.; Missirian, C.; Moreno, M.; Shi, W.; Gitton, Y. I.; Lombardini, A.; Vanzetta, I.; Mazaud-Guittot, S.; Chedotal, A.; Baudot, A.; Zaffran, S.; Etchevers, H. C.
10.1101/2024.11.21.624698 — developmental biology — Posted on 2025-01-09
4020 Optimisation of single-nuclei isolation and RNA sequencing of parasitic nematodes
Buddenborg, S. K.; Morrison, A.; Fletcher, A. C.; Kieninger, M. R.; Ng, B. L.; Maitland, K.; Hart, E.; Bartley, D.; Duque-Correa, M. A.; Doyle, S. R.
10.1101/2024.11.13.623282 — molecular biology — Posted on 2025-01-09
4021 Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.
Dholakia, V.; Quantrill, J. L.; Richardson, S.; Pankaew, N.; Brown, M. D.; Yang, J.; Capelastegui, F.; Masonou, T.; Case, K.-M.; Aejian, J.; Staller, E.; Sheppard, C. M.; Brown, I. H.; Smith, C. M.; Iqbal, M.; Digard, P.; Barclay, W. S.; Pinto, R. M.; Peacock, T. P.; Goldhill, D. H.
10.1101/2025.01.06.631435 — microbiology — Posted on 2025-01-09
4022 Functional constraints of wtf killer meiotic drivers
Srinivasa, A. N.; Campbell, S.; Venkatesan, S.; Nuckolls, N. L.; Lange, J. J.; Halfmann, R.; Zanders, S. E.
10.1101/2024.08.27.609905 — genetics — Posted on 2025-01-09
4023 Mapping Serotonergic Dynamics using Drug-Modulated Molecular Connectivity
Ionescu, T. M.; Amend, M.; Hafiz, R.; Maurer, A.; Biswal, B. B.; Wehrl, H. F.; Herfert, K.
10.1101/2024.02.08.579462 — neuroscience — Posted on 2025-01-09
4027 Physiological and molecular impairment of PV circuit homeostasis in mouse models of autism
Monday, H. R.; Nieto, A. M.; Yohannes, S. A.; Luxu, S.; Wong, K. W.; Bolio, F. E.; Feldman, D.
10.1101/2025.01.08.632056 — neuroscience — Posted on 2025-01-09
4028 Human hippocampal ripples predict the alignment of experience to a grid-like schema
Xiao, Z.; Wang, X.; Zhang, J.; Ou, J.; He, L.; Qu, Y.; Hu, X.; Behrens, T. E.; Liu, Y.
10.1101/2025.01.08.632069 — neuroscience — Posted on 2025-01-09
4031 Multi-dimensionality of tree communities structure host-parasitoid networks and their phylogenetic composition
Wang, M.-Q.; Guo, S.-K.; Guo, P.-F.; Yang, J.-J.; Chen, G.-A.; Chesters, D.; Orr, M. C.; Niu, Z.-Q.; Staab, M.; Chen, J.-T.; Li, Y.; Zhou, Q.-S.; Fornoff, F.; Shi, X.; Li, S.; Martini, M.; Klein, A.-M.; Schuldt, A.; Liu, X.; Ma, K.; Bruelheide, H.; Luo, A.; Zhu, C.-D.
10.1101/2024.06.13.598779 — ecology — Posted on 2025-01-09
4033 Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes
Gristick, H. B.; Hartweger, H.; Nishimura, Y.; Gavor, E.; Nagashima, K.; Koranda, N. S.; Gnanapragasam, P. N. P.; Kakutani, L. M.; Segovia, L.; Donau, O.; Keeffe, J. R.; West, A. P.; Martin, M. A.; Nussenzweig, M. C.; Bjorkman, P. J.
10.1101/2025.01.08.632013 — bioengineering — Posted on 2025-01-09
4035 Chiari II brain malformation is secondary to open spina bifida
Clark, M.; Edwards, T. J.; Savery, D.; Galea, G. L.; Samy, N.; Pauws, E.; Kessaris, N.; Greene, N. D.; Copp, A. J.
10.1101/2025.01.06.631442 — developmental biology — Posted on 2025-01-09
4036 Fast adaptation of Myosin II activity to confinement sustains neutrophil migration in capillaries
Deygas, M.; Bernard, M.; Nivoit, P.; Barbier, L.; Wang, L.; Maurin, M.; Tejerina, E.; Jakuszeit, T.; Deslys, A.; Garcia-Gomez, M.; Baaziz, O.; Garbay, S.; Terriac, E.; Attia, R.; Dumenil, G.; Piel, M.; VARGAS, P.
10.1101/2025.01.08.631737 — cell biology — Posted on 2025-01-09
4037 Human REXO4 is Required for Cell Cycle Progression
Clutario, K. M.; Abdusamad, M.; Ramirez, I.; Rich, K. J.; Gholkar, A. A.; Zaragoza, J.; Torres, J. Z.
10.1101/2025.01.08.631954 — cell biology — Posted on 2025-01-09
4039 Age-Dependent Cortical Overconnectivity in Shank3 Mice is Reversed by Anesthesia
Montagni, E.; Ambrosone, M.; Martello, A.; Curti, L.; Baroncelli, L.; Mannaioni, G.; Pavone, F.; Masi, A.; Allegra Mascaro, A. L.
10.1101/2024.08.13.607775 — neuroscience — Posted on 2025-01-09
4040 Genome organization by SATB1 binding to base-unpairing regions (BURs) provides scaffold for SATB1-regulated gene expression
Kohwi, Y.; Wong, X.; Grange, M.; Sexton, T.; Richards, H. W.; Kitagawa, Y.; Sakaguchi, S.; Liang, Y.-C.; Chuong, C.-M.; Botchkarev, V.; Taniuchi, I.; Reddy, K. L.; Kohwi-Shigematsu, T.
10.1101/2021.12.19.473323 — genomics — Posted on 2025-01-09
4042 CLCNet: a contrastive learning and chromosome-aware network for genomic prediction in plants
Huang, J.; Yang, Z.; Yin, M.; Li, C.; Li, J.; Wang, Y.; Huang, L.; He, F.; Liang, C.; Li, M.; Han, R.; Jiang, Y.
10.1101/2024.12.29.630569 — bioinformatics — Posted on 2025-01-09
4043 Ecological not social factors explain brain size in cephalopods
Basava, K.; Bendixen, T.; Leonhard, A.; George, N. L.; Vanhersecke, Z.; Omotosho, J.; Mather, J.; Muthukrishna, M.
10.1101/2024.05.01.592020 — evolutionary biology — Posted on 2025-01-09
4045 Two independent translocation modes drive neural stem cell dissemination into the human fetal cortex
Wimmer, R.; Lestienne, P.; Brunet, C.; Di Cicco, A.; Chehade, C.; Artioli, A.; Cortes, M.; Mace, A. S.; Fraisier, V.; WANG, X.; Manneville, J. B.; Bessiere, B.; Roy, A.; Forsberg Nilsson, K.; Ladewig, J.; Guimiot, F.; Baffet, A. D.
10.1101/2025.01.08.631865 — neuroscience — Posted on 2025-01-09
4048 Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5'- and 3'-ends
Luyties, O.; Sanford, L.; Rodino, J.; Nagel, M.; Jones, T.; Rimel, J. K.; Ebmeier, C. C.; Shelby, G. S.; Cozzolino, K.; Brennan, F.; Hartzog, A.; Saucedo, M. B.; Watts, L. P.; Spencer, S. L.; Kugel, J. L.; Dowell, R. D.; Taatjes, D. J.
10.1101/2025.01.08.632016 — biochemistry — Posted on 2025-01-09
4050 Landscape of human protein-coding somatic mutations across tissues and individuals
Xu, H.; Bierman, R.; Akey, D.; Koers, C.; Comi, T.; McWhite, C. D.; Akey, J. M.
10.1101/2025.01.07.631808 — genomics — Posted on 2025-01-09
4051 Evolutionary sparse learning with paired species contrast reveals the shared genetic basis of convergent traits
Kumar, S.; Allard, J. B.; Sharma, S.; Patel, R.; Sanderford, M. D.; Tamura, K.; Vucetic, S.; Gerhard, G. S.
10.1101/2025.01.08.631987 — evolutionary biology — Posted on 2025-01-09
4053 MicroRNA signatures of VO2peak in older adult participants of the Study of Muscle, Mobility and Aging
Karere, G.; Hsu, F.-C.; Hepple, R. T.; Coen, P. M.; Cummings, S.; Newman, A.; Glynn, N. W.; Sparks, L.; Lane, N. E.; Xu, J.; Wagner, N.; Li, G.; Chan, J.; Cox, L. A.; Kritchevsky, S.
10.1101/2025.01.08.631999 — molecular biology — Posted on 2025-01-09
4054 The 2.3 A Structure of A21, a Protein Component of the Conserved Poxvirus Entry-Fusion Complex
Diesterbeck, U. S.; Muslinkina, L.; Gittis, A. G.; Singh, K.; Moss, B.; Garboczi, D. N.
10.1101/2025.01.08.631918 — molecular biology — Posted on 2025-01-09
4055 Extracellular vesicles of a phytobeneficial bacterium trigger distinct systemic response in plant
Zannis-Peyrot, T.; Degusseau, L.; Dugas, P.-Y.; Bastian, F.; Gaucher, M.; Gaillard, V.; Comte, G.; Wisniewski-Dye, F.; Kerzaon, I.; Lavire, C.; Vial, L.
10.1101/2025.01.08.631853 — microbiology — Posted on 2025-01-09
4060 Distinct roles of cortical layer 5 subtypes in associative learning
Moberg, S.; Garibbo, M.; Mazo, C.; Gilad, A.; Schmitz, D.; Costa, R. P.; Larkum, M. E.; Takahashi, N.
10.1101/2025.01.07.631500 — neuroscience — Posted on 2025-01-09
4063 Higher-order EEG microstate syntax and surrogate testing
von Wegner, F.; Hermann, G.; Tödt, I.; Todtenhaupt, I. K.; Laufs, H.
10.1101/2025.01.07.631820 — neuroscience — Posted on 2025-01-09
4064 Long-term homeostasis in microbial consortia via auxotrophic cross-feeding
Grandel, N. E.; Alexander, A. M.; Peng, X.; Palamountain, C.; Alnahhas, R. N.; Hirning, A. J.; Josic, K.; Bennett, M. R.
10.1101/2025.01.08.631749 — synthetic biology — Posted on 2025-01-09
4066 Network-based framework for studying etiology and phenotype diversity in primary ciliopathies
Aarts, E. M.; Laman Trip, D. S.; Neatu, R.; Martin, C. G.; Riley, B.; Kraus, A.; Green, A.; Al-Hamed, M. H.; Armstrong, R. E.; Sayer, J.; Bachmann-Gagescu, R.; Beltrao, P.
10.1101/2025.01.08.631887 — genetics — Posted on 2025-01-09
4067 Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors
Corso Diaz, X.; Liang, X.; Preston, K.; Tegshee, B.; English, M. A.; Nellissery, J.; Yadav, S. P.; Marchal, C.; Swaroop, A.
10.1101/2024.09.19.613899 — molecular biology — Posted on 2025-01-08
4068 Molecular characterisation of common Culicoides Biting Midges (Diptera: Ceratopogonidae) in Ireland
Isiye, E.; Olmeda, A. V.; Curran, T.; O'Neill, D.; de Waal, T.; Barry, G.; O'Hanlon, A.; O'Shaughnessy, J.; McCarthy, N. K.; Vellinga, A.; Jenkinson, A.; Johnson, A.; Barrett, D.; Costello, S.; Zintl, A.; O'Meara, D.
10.1101/2025.01.08.631704 — molecular biology — Posted on 2025-01-08
4071 Characterization of Clinical Fusobacterium nucleatum Isolates from Oral Squamous Cell Carcinoma Patients
Lim, S.; Hsueh, W.-H.; Hodges, C.; Vuong, C.; Smith, K.; Hsiao, J.-R.; Chang, J. S.; Chang, J.-Y.; Chen, J.-W.; Huang, I.-H.
10.1101/2025.01.08.631950 — microbiology — Posted on 2025-01-08
4072 Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa determines specific clinically relevant phenotypes and infection outcome
Bosc, L.; Secher, T.; Ball, G.; Le Pennec, D.; Tribout, M.; Moly, B.; Bai, Y.; Ouerdane, L.; Arnoux, P.; Denis, Y.; Lei, X.; Bordi, C.; Heuze-Vourc'h, N.; Haussler, S.; Gomez, N. O.; Voulhoux, R.
10.1101/2025.01.08.631948 — microbiology — Posted on 2025-01-08
4073 Protein and genomic language models chart a vast landscape of antiphage defenses
Mordret, E.; Herve, A.; Vaysset, H.; Clabby, T.; Tesson, F.; Shomar, H.; Lavenir, R.; Cury, J.; Bernheim, A.
10.1101/2025.01.08.631966 — microbiology — Posted on 2025-01-08
4075 Bacterial and host enzymes modulate the inflammatory response produced by the peptidoglycan of the Lyme disease agent
McCausland, J. W.; Kloos, Z. A.; Irnov, I.; Sonnert, N. D.; Zhou, J.; Putnick, R.; Mueller, E. A.; Steere, A. C.; Palm, N. W.; Grimes, C. L.; Jacobs-Wagner, C.
10.1101/2025.01.08.631998 — microbiology — Posted on 2025-01-08
4076 ATF6 enables pathogen infection in ticks by inducing stomatin and altering cholesterol dynamics
Vosbigian, K. A.; Wright, S. J.; Rosche, K. L.; Fisk, E. A.; Ramirez-Zepp, E.; Shelden, E. A.; Shaw, D. K.
10.1101/2025.01.08.632023 — microbiology — Posted on 2025-01-08
4077 Genome Analysis of Bacillus paralicheniformis AA1 isolated from a conventional milpa farming system in the northwestern region of Sonora, Mexico
Verdugo-Fuentes, A. A.; Chavez-Almanza, A.; Villa-Rodriguez, E.; Rojas-Padilla, J.; Cantu-Soto, E.; Diaz-Quiroz, C.
10.1101/2025.01.08.631978 — microbiology — Posted on 2025-01-08
4080 Trace metals availability controls terminal electron acceptor utilization in Escherichia coli
Ricciardelli, A.; de Pins, B.; Brusca, J.; Correggia, M.; di Iorio, L.; Cascone, M.; Giardina, M.; Castaldi, S.; Isticato, R.; Iacono, R.; Moracci, M.; Nappi, N.; Pollio, A.; Vetriani, C.; Leone, S.; Cordone, A.; Giovannelli, D.
10.1101/2025.01.08.631794 — microbiology — Posted on 2025-01-08
4084 Iron-sulfur cluster proteins present the weak spot in plasma-treated Escherichia coli
Krewing, M.; Weisgerber, K. M.; Dirks, T.; Bobkov, I.; Schubert, B.; Bandow, J. E.
10.1101/2025.01.08.631878 — microbiology — Posted on 2025-01-09
4089 GABRA1 frameshift variants impair GABAA receptor proteostasis
Williams, M. P.; Wang, Y.-J.; Kang, J.-Q.; Perryman, J. H.; Mu, T.
10.1101/2024.11.28.625971 — cell biology — Posted on 2025-01-08
4090 Protosequences in brain organoids model intrinsic brain states
van der Molen, T.; Spaeth, A.; Chini, M.; Hernandez, S.; Kaurala, G. A.; Schweiger, H. E.; Duncan, C.; McKenna, S.; Geng, J.; Lim, M.; Bartram, J.; Dendukuri, A.; Zhang, Z.; Gonzalez-Ferrer, J.; Bhaskaran-Nair, K.; Blauvelt, L. J.; Harder, C. R. K.; Petzold, L. R.; Alam El Din, D.-M.; Laird, J.; Schenke, M.; Smirnova, L.; Colquitt, B. M.; Mostajo-Radji, M. A.; Hansma, P. K.; Teodorescu, M.; Hierlemann, A.; Hengen, K. B.; Hanganu-Opatz, I. L.; Kosik, K. S.; Sharf, T.
10.1101/2023.12.29.573646 — neuroscience — Posted on 2025-01-08
4091 Modeling the acutely injured brain environment in vitro.
Maria Arzate, D.; Alvaro, V.; Pradanos-Senen, A. V.; Gallego, L.; Manzano, D.; Llorente-Saez, C.; Bartolome, R.; Ferrarini, A.; Lopez, J. A.; Murenu, E.; Berninger, B.; Ortega, F.; Goetz, M.; Heinrich, C.; Gascon, S.
10.1101/2025.01.08.631921 — neuroscience — Posted on 2025-01-08
4092 Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy Responses
Lei, J. T.; Dobrolecki, L. E.; Huang, C.; Srinivasan, R. R.; Vasaikar, S. V.; Lewis, A. N.; Sallas, C.; Zhao, N.; Cao, J.; Landua, J. D.; Moon, C. I.; Liao, Y.; Hilsenbeck, S. G.; Osborne, C. K.; Rimawi, M. F.; Ellis, M. J.; Petrosyan, V.; Wen, B.; Li, K.; Saltzman, A. B.; Jain, A.; Malovannaya, A.; Wulf, G. M.; Marangoni, E.; Li, S.; Kraushaar, D. C.; Wang, T.; Damodaran, S.; Zheng, X.; Meric-Bernstam, F.; Echeverria, G. V.; Anurag, M.; Chen, X.; Welm, B. E.; Welm, A. L.; Zhang, B.; Lewis, M. T.
10.1101/2024.12.09.627518 — cancer biology — Posted on 2025-01-08
4094 Torsion-Induced Traumatic Optic Neuropathy (TITON): A Physiologically Relevant Animal Model of Traumatic Optic Neuropathy
Ryan, A. K.; Asemota, B. I.; Heisler-Taylor, T.; Mello, C.; Rodriguez, L.; Sponsel, W. E.; Racine, J.; Rex, T. S.; Glickman, R. D.; Reilly, M. A.
10.1101/2024.10.08.617086 — bioengineering — Posted on 2025-01-08
4096 A novel motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin
Bradburn, D. A.; Reis, J. C.; Qayyum, S.; Viennet, T.; Arthanari, H.; Cyert, M. S.
10.1101/2024.05.12.593783 — biochemistry — Posted on 2025-01-08
4099 ChromBPNet: bias factorized, base-resolution deep learning models of chromatin accessibility reveal cis-regulatory sequence syntax, transcription factor footprints and regulatory variants
Pampari, A.; Shcherbina, A.; Kvon, E. Z.; Kosicki, M.; Nair, S.; Kundu, S.; Kathiria, A. S.; Risca, V. I.; Kuningas, K.; Alasoo, K.; Greenleaf, W.; Pennacchio, L.; Kundaje, A.
10.1101/2024.12.25.630221 — genetics — Posted on 2025-01-08
4100 Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex
Sellitto, S.; Caredio, D.; Bimbati, M.; Mariutti, G.; Cerisoli, M.; Frick, L.; Bouris, V.; Morales, C. O. O.; Vena, D. L.; Neupane, S.; Baroni, F.; Ging, K.; Yin, J.-A.; De Cecco, E.; Armani, A.; Aguzzi, A.
10.1101/2024.10.21.619371 — cell biology — Posted on 2025-01-08
4101 Screening for variable drug responses using human iPSC cohorts
Platani, M.; Jiang, H.; Davidson, L.; Hariharan, S.; Doyonnas, R.; Lamond, A. I.; Swedlow, J. R.
10.1101/2023.06.16.545161 — cell biology — Posted on 2025-01-08
4102 Methanogens are associated with altered microbial production of short-chain fatty acids and human-host metabolizable energy
Dirks, B.; Davis, T. L.; Carnero, E. A.; Corbin, K. D.; Smith, S. R.; Rittmann, B. E.; Krajmalnik-Brown, R.
10.1101/2024.12.31.630929 — microbiology — Posted on 2025-01-08
4105 Endocannabinoids facilitate transitory reward engagement through retrograde gain control
Marcus, D. J.; English, A. E.; Chun, G.; Seth, E. F.; Oomen, R.; Hwang, S.; Wells, B. A.; Piantadosi, S. C.; Suko, A.; Li, Y.; Zweifel, L.; Land, B. B.; Stella, N.; Bruchas, M.
10.1101/2025.01.06.630792 — neuroscience — Posted on 2025-01-08
4106 Differential encoding of odor and place in mouse piriform and entorhinal cortex
Mena, W.; Baker, K.; Rubin, A.; Kohli, S.; Yoo, Y.; Ziv, Y.; Razaei-Mazinani, C.; Fleischmann, A.
10.1101/2023.10.05.561119 — neuroscience — Posted on 2025-01-08
4110 WormID-Benchmark: Extracting Whole-Brain Neural Dynamics of C. elegans At the Neuron Resolution
Adhinarta, J.; Dong, J.; He, T.; Sprague, D.; Wan, J.; Lee, H. J.; Yu, Z.; Lu, H.; Yemini, E.; Kato, S.; Varol, E.; Wei, D.
10.1101/2025.01.06.631621 — neuroscience — Posted on 2025-01-08
4112 Cortical sensory aging is layer-specific
Liu, P.; Doehler, J.; Henschke, J. U.; Northall, A.; Serian, A.; Loaiza-Carvajal, L. C.; Budinger, E.; Schwarzkopf, D. S.; Speck, O.; Pakan, J. M. P.; Kuehn, E.
10.1101/2023.12.01.567841 — neuroscience — Posted on 2025-01-08
4114 Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use
Barekat, K.; Ricciotti, E.; Ghosh, S.; Herrmann, C.; Keat, K.; Assenmacher, C.-A.; Tanes, C.; Wilson, N.; Sengupta, A.; Das, U. S.; Joshi, R.; Ritchie, M.; Bittinger, K.; Weljie, A.; Cadwell, K.; Bushman, F.; Wu, G.; FitzGerald, G. A.
10.1101/2024.11.22.624882 — pharmacology and toxicology — Posted on 2025-01-08
4122 Audiovisual cues must be predictable and win-paired to drive risky choice
Hathaway, B. A.; Kim, D. R.; Malhas, S. B. A.; Hrelja, K. M.; Kerker, L.; Hynes, T. J.; Harris, C.; Langdon, A. J.; Winstanley, C. A.
10.1101/2022.09.20.507379 — animal behavior and cognition — Posted on 2025-01-08
4125 Single molecule Lipid Biosensors Mitigate Inhibition of Endogenous Effector Proteins
Holmes, V.; Ricci, M. M. C.; Weckerly, C. C.; Worcester, M.; Hammond, G. R.
10.1101/2024.09.11.612480 — cell biology — Posted on 2025-01-08
4129 Hypoxia-inducible factor 1α is required to establish the larval glycolytic program in Drosophila melanogaster
Heidarian, Y.; Fasteen, T. D.; Mungcal, L.; Buddika, K.; Mahmoudzadeh, N. H.; Nemkov, T.; D'Alessandro, A.; Tennessen, J.
10.1101/2025.01.07.631819 — developmental biology — Posted on 2025-01-08
4134 The spinal premotor network driving scratching flexor and extensor alternation
Yao, M.; Nagamori, A.; Azim, E.; Sharpee, T.; Goulding, M.; Golomb, D.; Gatto, G.
10.1101/2025.01.08.631866 — neuroscience — Posted on 2025-01-08
4135 Physiologically-relevant light exposure and light behaviour in Switzerland and Malaysia
Biller, A.; Zauner, J.; Cajochen, C.; Gerle, M. A.; Kalavally, V.; Mohammed, A.; Rottlaender, L.; Seah, M.-Y.; Stefani, O.; Spitschan, M.
10.1101/2025.01.07.631760 — neuroscience — Posted on 2025-01-08
4137 Nondestructive Detection and Quantification of Dysprosium in Plant Tissues
Hernandez-Pagan, E.; Laosuntisuk, K.; Harris, A. T.; Haynes, A. N.; Buitrago, D.; Rajabu, C.; Kudenov, M. W.; Doherty, C. J.
10.1101/2025.01.07.631589 — plant biology — Posted on 2025-01-08
4139 The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure
Haddox, H. K.; Angehrn, G.; Sesta, L.; Jennings-Shaffer, C.; Temple, S. D.; Galloway, J. G.; DeWitt, W. S.; Bloom, J. D.; Matsen, F. A.; Neher, R. A.
10.1101/2025.01.07.631013 — bioinformatics — Posted on 2025-01-08
4141 A Microphysiological Model of Progressive Human Hepatic Insulin Resistance
Hellen, D. J.; Ungerleiger, J.; Tevonian, E.; Sphabmixay, P.; Roy, P.; Chidley, C.; Jeppesen, J.; Demozay, D.; Griffith, L. G.
10.1101/2025.01.08.631261 — bioengineering — Posted on 2025-01-08
4142 Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC)
Monsen, P. J.; Bommi, P. V.; Grigorescu, A. A.; Lauing, K. L.; Mao, Y.; Berardi, P.; Zhai, L.; Ojo, O.; Penco-Campillo, M.; Koch, T.; Egozi, M.; Jha, S. V.; Dunne, S. F.; Jiang, H.; Song, G.; Zhang, F.; Kregel, S.; Vaziri-Gohar, A.; Fanning, S.; Sanchez-Gomez, P.; Allen, J. M.; Yamini, B.; Lukas, R. V.; Wainwright, D. A.; Schiltz, G. E.
10.1101/2025.01.07.631731 — biochemistry — Posted on 2025-01-08
4143 Probabilities of finding trace profile donors and their paternal relatives in Y-STR reference databases
Olsen, T. O. S.; Morling, N.; Eriksen, P. S.; Kampmann, M.-L.; Mogensen, H. S.; Andersen, M. M.
10.1101/2025.01.08.631054 — genetics — Posted on 2025-01-08
4144 Genome-wide Viral Nascent RNA Sequencing Unveils Polymerase Pausing Landscape at Single-nucleotide Precision
Zhu, Z.; Fung, C. W.; Xu, X.; Liang, Z.; Gao, Z.; Wang, M. H.; Li, M.; Yeung, S. Y.; Wang, J.; Tse, C. K. M.; Cheung, P. P.-H.
10.1101/2025.01.08.631631 — genetics — Posted on 2025-01-08
4146 Disentangling the evolutionary history of terrestrial planarians through phylogenomics
Benitez-Alvarez, L.; Escudero, N.; Salces-Ortiz, J.; Rojo, I.; Fernandez-Alvarez, F. A.; Mateos, E.; Carbayo, F.; Fernandez, R.
10.1101/2025.01.07.631701 — evolutionary biology — Posted on 2025-01-08
4147 Gut meta-virome reveals potential zoonotic pathogens and environmental RNA viruses carried by non-human primates
Yan, Y.; LI, Y.; Yang, L.; Wu, H.; Wu, F.; Chang, H.; Hu, Z.; He, S.; Ren, Y.; Zhu, L.; Li, B.; Guo, S.
10.1101/2025.01.07.631708 — ecology — Posted on 2025-01-08
4148 Nitrification in a seagrass-sponge association
Berlinghof, J.; Montilla, L. M.; Meador, T. B.; Gallucci, L.; Giovannelli, D.; Gruber-Vodicka, H.; Maselli, M.; Margiotta, F.; Wild, C.; Cardini, U.
10.1101/2025.01.07.631680 — ecology — Posted on 2025-01-08
4151 RNase III cleavage signals spread across splice junctions enforce sequential processing of co-hosted snoRNAs.
Migeot, V.; Mary, Y.; Fafard-Couture, E.; Lombard, P.; Bachand, F.; Scott, M. S.; Yague-Sanz, C.
10.1101/2025.01.08.631648 — molecular biology — Posted on 2025-01-08
4152 Identification and characterization of novel bat coronaviruses in Spain
Soriano-Tordera, C.; Buigues, J.; Vinals, A.; Muscolino, E.; Martinez-Recio, R.; Diez, J.; Monros, J. S.; Cuevas, J. M.; Dufloo, J.; Sanjuan, R.
10.1101/2025.01.07.631674 — microbiology — Posted on 2025-01-08
4154 Eye metrics are a marker of visual conscious awareness and neural processing in cerebral blindness
Kronemer, S. I.; Gobo, V. E.; Japee, S.; Merriam, E.; Osborne, B.; Bandettini, P. A.; Liu, T.
10.1101/2025.01.06.631506 — neuroscience — Posted on 2025-01-08
4155 LPS-induced sepsis disrupts brain activity in a region- and vigilance-state specific manner
Leemburg, S.; Kala, A.; Nataraj, A.; Karkusova, P.; Baindur, S.; Suresh, A.; Blahna, K.; Jezek, K.
10.1101/2024.12.25.630319 — neuroscience — Posted on 2025-01-08
4156 2-Deoxy-D-glucose chemical exchange-sensitive spin-lock MRI of cerebral glucose metabolism after stroke in the rat
Boehm-Sturm, P.; Schuenke, P.; Foddis, M.; Mueller, S.; Koch, S. P.; Beard, D. J.; Holloway, P.; Mottahedin, A.; Schroeder, L.; Buchan, A. M.; Mergenthaler, P.
10.1101/2025.01.08.628135 — neuroscience — Posted on 2025-01-08
4159 Potato Late Blight Control with a Botanical Product and Reduced Copper Applications
Musa, T.; Kagi, A.; Gutlin, H.; Schnee, S.; Massana-Codina, J.; Sullam, K. E.
10.1101/2025.01.08.627882 — plant biology — Posted on 2025-01-08
4160 Maturase K forms a plastidial splicing complex with a neofunctionalized branching enzyme
Liang, Y.; Gao, Y.; Fontana, A.; Abt, M. R.; Gicgier, A. P.; Liu, C.; Sharma, M.; Zoschke, R.; Zeeman, S. C.; Pfister, B.
10.1101/2025.01.08.628318 — plant biology — Posted on 2025-01-08
4161 SERUM AND PLASMA SPHINGOLIPIDS AS BIOMARKERS OFANTHRACYCLINE-INDUCED CARDIOTOXICITY
Mohammed, S.; Kalogeropoulos, A. P.; Alvarado, V.; Weisfelner-Bloom, M.; Clarke, C. J.
10.1101/2025.01.06.631494 — physiology — Posted on 2025-01-08
4164 The Peptonizer2000: bringing confidence to metaproteomics
Holstein, T.; Verschaffelt, P.; Van de Vyver, S.; Van den Bossche, T.; Mesuere, B.; Martens, L.; Muth, T.
10.1101/2024.05.20.594958 — bioinformatics — Posted on 2025-01-08
4166 AAVone: A Cost-Effective, Single-Plasmid Solution for Efficient AAV Production with Reduced DNA Impurities
Yang, R.; Tran, N. T.; Chen, T.; Cui, M.; Wang, Y.; Sharma, T.; Liu, Y.; Zhang, J.; Yuan, X.; Zhang, D.; Chen, C.; Shi, Z.; Wang, L.; Dai, Y.; Zaidi, H.; Liang, J.; Chen, M.; Jaijyan, D.; Hu, H.; Wang, B.; Xu, C.; Hu, W.; Gao, G.; Yu, D.; Tai, P. W. L.; Wang, Q.
10.1101/2025.01.07.631712 — bioengineering — Posted on 2025-01-08
4167 Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3
Snow, A. J. D.; Wijesiriwardena, T.; Lane, B. J.; Farrell, B.; Dowdle, P. C.; Katan, M.; muench, s. P.; Breeze, A.
10.1101/2024.06.04.596442 — biochemistry — Posted on 2025-01-08
4168 Plasma Cell-Free DNA in Acute and Chronic Aortic Syndromes.
Weerakkody, R. A.; Adamowicz, M.; Robert, C.; Pound, J.; Syed, M.; Pumpe, C.; Bilal, A.; Laird, A.; McLaren, D. B.; Falah, O.; Tambyraja, A.; Reed, M. J.; Newby, D. E.; Aitman, T. J.
10.1101/2025.01.06.631373 — genomics — Posted on 2025-01-08
4169 Circulating mitochondrial bioenergetics as fingerprint of the hepatic one: how to monitor genetic MASLD
Paolini, E.; Longo, M.; Meroni, M.; Podini, P.; Maggioni, M.; Quattrini, A.; Fracanzani, A. L.; Dongiovanni, P.
10.1101/2024.05.06.592717 — genetics — Posted on 2025-01-08
4170 Beyond venomous fangs: Uloboridae spiders have lost their venom but not their toxicity
Peng, X.; Dersch, L.; Dresler, J.; Lüddecke, T.; Dederichs, T.; Michalik, P.; Peigneur, S.; Tytgat, J.; Hassan, A.; Mucciolo, A.; Robinson-Rechavi, M.; Zancolli, G.
10.1101/2023.06.26.546488 — evolutionary biology — Posted on 2025-01-08
4171 Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths
Lindhout, F. W.; Szafranska, H. M.; Imaz-Rosshandler, I.; Guglielmi, L.; Moarefian, M.; Voitiuk, K.; Zernicka-Glover, N. K.; Boulanger, J.; Schulze, U.; Lloyd-Davies Sanchez, D. J.; Minnick, J.; Teodorescu, M.; Lancaster, M. A.
10.1101/2024.12.28.630576 — developmental biology — Posted on 2025-01-08
4173 HIV-1 protein coding sequences are present in relevant bacteria
Pelaez-Prestel, H. F.; Mozas-Gutierrez, J.; Lafuente, E. M.; Reche, P. A.
10.1101/2024.12.04.626764 — microbiology — Posted on 2025-01-08
4177 Loss of Elp3 impairs the maturation tempo of brain ependymal cells
Tielens, S.; Boutin, C.; Huysseune, S.; Thelen, N.; Charlet-Briart, M.; Reyskens, C.; Oskera, L.; Boutsen, A.; Mateo-Sanchez, S.; Delacroix, L.; Labedan, P.; Thiry, M.; Malgrange, B.; Chariot, A.; Tissir, F.; Creppe, C.; Seuntjens, E.; Laguesse, S.; Nguyen, L.
10.1101/2025.01.07.631730 — neuroscience — Posted on 2025-01-08
4178 Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR): A Novel Method revealing bortezomib resistance mechanisms in Multiple Myeloma
Arguello, R. J.; Pierre, P.; Gigan, J. P.; Garcia-Gonzalez, P.; Galliot, L.; Ghaffar, Y.; Flores-Santibanez, F.; Seillier, E.; Lavignolle-Heguy, R.; Dos Santos, D.; Fischaux, S.; Combes, A.; Narita, M.; Gatti, E.; Nal, B.; Rocchi, S.; Moreaux, J.
10.1101/2024.10.22.617161 — cancer biology — Posted on 2025-01-08
4179 mimicINT: a workflow for microbe-host protein interaction inference
Choteau, S. A.; Maldonado, K.; Bergon, A.; Cristianini, M.; Drets, L.; Boujeant, M.; Brun, C.; Spinelli, L.; Zanzoni, A.
10.1101/2022.11.04.515250 — bioinformatics — Posted on 2025-01-08
4180 The Rise of Open Data Practices Among Bioscientists at the University of Edinburgh
Deeb, H.; Creasey, S.; de Ugarte, D. L.; Strevens, G.; Usman, T.; Wong, H. Y.; Kutzer, M. A. M.; Wilson, E.; Zielinski, T.; Millar, A. J.
10.1101/2024.02.18.580901 — bioinformatics — Posted on 2025-01-08
4181 Deep Learning for Biomarker Discovery in Cancer Genomes
Unger, M.; Loeffler, C. M. L.; Zigutyte, L.; Sainath, S.; Lenz, T.; Vibert, J.; Mock, A.; Froehling, S.; Graham, T. A.; Carrero, Z. I.; Kather, J. N.
10.1101/2025.01.06.631471 — bioinformatics — Posted on 2025-01-08
4182 CLCNet: a contrastive learning and chromosome-aware network for genomic prediction in plants
Huang, J.; Yang, Z.; Yin, M.; Li, C.; Li, J.; Wang, Y.; Huang, L.; He, F.; Liang, C.; Li, M.; Han, R.; Jiang, Y.
10.1101/2024.12.29.630569 — bioinformatics — Posted on 2025-01-08
4183 Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology
Zigutyte, L.; Lenz, T.; Han, T.; Hewitt, K. J.; Reitsam, N. G.; Foersch, S.; Carrero, Z.; Unger, M.; Pearson, A. T.; Truhn, D.; Kather, J. N.
10.1101/2024.10.29.620913 — bioinformatics — Posted on 2025-01-08
4185 A high-throughput protein tagging toolkit that retains endogenous UTRs for studying gene regulation in Kinetoplastids.
Carbajo, C. G.; Han, X.; Savur, B.; Upadhyaya, A.; Taha, F.; Tinti, M.; Wheeler, R. J.; Yates, P. A.; Tiengwe, C.
10.1101/2024.11.02.621556 — molecular biology — Posted on 2025-01-08
4186 CapP mediates the structural formation of biofilm-specific pili in the opportunistic human pathogen Bacillus cereus
Alvarez-Mena, A.; Shukkoor, M. B. A.; Caro-Astorga, J.; Berbon, M.; Gomez, M. L. A.; Grelard, A.; Kauffmann, B.; Morvan, E.; de Vicente, A.; Habestein, B.; Loquet, A.; Romero, D.
10.1101/2024.02.27.582368 — microbiology — Posted on 2025-01-08
4191 Exploring the repository of de novo designed bifunctional antimicrobial peptides through deep learning
Dong, R.; Liu, R.; Liu, Z.; Liu, Y.; Zhao, G.; Li, H.; Hou, S.; Ma, X.; Kang, H.; Liu, J.; Guo, F.; Zhao, P.; Wang, J.; Wang, C.; Wu, X.; Ye, S.; Zhu, C.
10.1101/2024.02.23.581845 — bioinformatics — Posted on 2025-01-08
4192 TRIM21-NUP98 interface accommodates structurally diverse molecular glue degraders
Cheng, Y.; Cao, L.; Lu, P.; Xue, L.; Li, X.; Wang, Q.; Dou, D.; Li, J.; Han, T.
10.1101/2025.01.07.631691 — biochemistry — Posted on 2025-01-08
4193 Distinct Control of histone H1 expression within the Histone Locus body by CRAMP1
Bodner, J.; Vadlamani, P.; Helmin, K. A.; Liu, Q.; Mendillo, M. L.; Singer, B. D.; Srivastava, S.; Foltz, D. R.
10.1101/2025.01.07.631602 — genomics — Posted on 2025-01-08
4195 Cleavage cascade of the sigma regulator FecR orchestrates TonB-dependent signal transduction
Yokoyama, T.; Miyazaki, R.; Suzuki, T.; Dohmae, N.; Nagai, H.; Tsukazaki, T.; Kubori, T.; Akiyama, Y.
10.1101/2025.01.06.631622 — immunology — Posted on 2025-01-08
4197 Modeling the acutely injured brain environment in vitro.
Maria Arzate, D.; Alvaro, V.; Pradanos-Senen, A. V.; Gallego, L.; Manzano, D.; Llorente-Saez, C.; Bartolome, R.; Ferrarini, A.; Lopez, J. A.; Murenu, E.; Berninger, B.; Ortega, F.; Goetz, M.; Heinrich, C.; Gascon, S.
10.1101/2025.01.08.631921 — neuroscience — Posted on 2025-01-08
4199 Optimizing the Efficacy of Vaccine-Induced Immunotherapy in Melanomas
Chamseddine, I.; Kambara, M.; Bhatt, P.; Pilon-Thomas, S.; Rejniak, K. A.
10.1101/2025.01.06.631283 — systems biology — Posted on 2025-01-08
4201 Growth Hormone Excess Drives Liver Aging via increased Glycation stress
Singh, P.; Gautam, A.; Trujillo, M.; Galligan, J.; Hensley, L.; Kapahi, P.; Bartke, A.
10.1101/2025.01.06.631635 — physiology — Posted on 2025-01-08
4206 QUICHE reveals structural definitions of anti-tumor responses in triple negative breast cancer
Ranek, J. S.; Greenwald, N. F.; Goldston, M.; Fullaway, C. C.; Sowers, C.; Kong, A.; Mouron, S.; Quintela-Fandino, M.; West, R. B.; Angelo, M.
10.1101/2025.01.06.631548 — bioinformatics — Posted on 2025-01-08
4207 DNALONGBENCH: A Benchmark Suite for Long-Range DNA Prediction Tasks
Cheng, W.; Song, Z.; Zhang, Y.; Wang, S.; Wang, D.; Yang, M.; Li, L.; Ma, J.
10.1101/2025.01.06.631595 — bioinformatics — Posted on 2025-01-08
4212 DNA data (genome skims and metabarcodes) paired with chemical data demonstrate utility for retrospective analysis of forage linked to fatal poisoning of cattle
Cook, D.; Kocurek, B. J.; Stonecipher, C.; Welch, K. D.; Gardner, D. R.; Mammel, M. K.; Reed, E.; Ramachandran, P.; Erickson, D.; Commichaux, S.; Ottesen, A.
10.1101/2025.01.06.631623 — genomics — Posted on 2025-01-08
4214 CENdetectHOR: a comprehensive tool for CENtromere profiling and HOR detection
Daponte, A.; Pagliuca, P.; Vila-Verde, C. F.; Montinaro, F.; Antonacci, F.; Ventura, M.; Ceriani, M.; Catacchio, C. R.
10.1101/2025.01.07.631657 — genetics — Posted on 2025-01-08
4217 Hypoxia-Mediated Molecular Interactions of Tissue-Specific Mesenchymal Stem Cells Drive Metabolic Reprogramming and Immunomodulation in Acute Graft-versus-Host Disease
Mendiratta, M.; Mendiratta, M.; Malhotra, L.; Rai, S.; Sarangathem, V.; Dahiya, P.; Gupta, R.; Bakhshi, S.; Dadhwal, V.; Pushpam, D.; Aggarwal, M.; Gupta, A. K.; Malik, P. S.; Pramanik, R.; Mahapatra, M.; Seth, T.; Dhawan, R.; Bandyopadhyay, S.; Hariprasad, G.; Nayak, B.; Singh, T. D.; Kumar, S.; Mir, R. A.; Sharawat, S. K.; Prakash, H.; Mohanty, S.; Sahoo, R. K.
10.1101/2025.01.06.630457 — immunology — Posted on 2025-01-08
4218 Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotype
Ellul, P.; Fourcade, g.; Mhanna, V.; Coatnoan, N.; Bodula, S.; Seilhean, D.; Mouton, L.; Marguerit, G.; Delorme, R.; Mi, T.; Youngblood, B.; Rosenzwajg, M.; Tchitcheck, N.; Klatzmann, D.
10.1101/2025.01.06.631430 — immunology — Posted on 2025-01-08
4219 Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen
Pohl, L.; Wittenborn, T. R.; Shahrokhtash, A.; Kastberg, K. S.; Fahlquist-Hagert, C.; Jensen, L.; Sardella, D.; Pulfer, A.; Sutherland, D. S.; Gonzalez, S. F.; Schiessl, I. M.; Degn, S. E.
10.1101/2025.01.06.631523 — immunology — Posted on 2025-01-08
4220 Wnt signaling drives stromal inflammation in inflammatory arthritis
Mueller, A. A.; Zou, A. E.; Marsh, L.-J.; Kemble, S.; Nayar, S.; Watts, G. F. M.; Murphy, C. L.; Taylor, E.; Major, T.; Gardner, D.; Buckley, C. D.; Wei, K.; Raychaudhuri, S.; Korsunsky, I.; Filer, A.; Croft, A. P.; Brenner, M. B.
10.1101/2025.01.06.631510 — immunology — Posted on 2025-01-08
4221 RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir seeding in the Gut Mucosa
Perdios, C.; Suresh Babu, N.; Coleman, C. D.; Brown, A. T.; Mostrom, M. J.; Allers, C.; Doyle-Meyers, L.; Fennessey, C. M.; Keele, B. F.; Kaur, A.; Freeman, M. L.; Mudd, J. C.
10.1101/2025.01.06.631163 — immunology — Posted on 2025-01-08
4225 Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma
Joun, G. L.; Kempe, E. G.; Chen, B.; Sterling, J. R.; Abbassi, R. H.; du Preez, W. D.; Recasens, A.; Clark, T.; Du, T. Y.; Low, J. K.; Kim, H.; Yang, P.; Khor, J.; Hoque, M.; Idurthi, D. C.; Kuchibhotla, M.; Palanisamy, R.; Jorgensen, W. T.; Montgomery, A.; Baker, J.; Higginbottom, S.; Tomaskovic-Crook, E.; Crook, J. M.; Loo, L.; Day, B. W.; Neely, G.; Guccione, E.; Johns, T. G.; Kassiou, M.; Don, A. S.; Munoz, L.
10.1101/2025.01.06.631591 — cancer biology — Posted on 2025-01-08
4227 Hybrid supramolecular-covalent bioresin promotes cell migration and self-assembly in light-based volumetric bioprinted constructs
Falandt, M.; Bernal, P. N.; Longoni, A.; Buchholz, M.-B.; Quilis, P. C.; Widmann, K.; Barrera-Roman, M.; Malda, J.; Vermdonen, T.; Rios, A.; Levato, R.
10.1101/2025.01.06.631505 — bioengineering — Posted on 2025-01-08
4228 Improving MALDI Mass Spectrometry Imaging Performance: Low-Temperature Thermal Evaporation for Controlled Matrix Deposition and Improved Image Quality
Mahamdi, T.; Serna, C. G.; Gine, R.; Rofes, J.; Mohammed, S. A.; Rafols, P.; Correig, X.; Garcia-Altares, M.; Hopf, C.; Iakab, S. A.; Yanes, O.
10.1101/2025.01.06.631532 — bioengineering — Posted on 2025-01-08
4229 Ramp sequence may explain synonymous variant association with Alzheimer's disease in the Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA)
Miller, J. B.; Brandon, J. A.; McKinnon, L. M.; Sabra, H. W.; Lucido, C. C.; Murcia, J. D. G.; Nations, K. A.; Payne, S. H.; Ebbert, M.; Kauwe, J. S.; Ridge, P. G.
10.1101/2025.01.06.631528 — genetics — Posted on 2025-01-08
4230 Modelling forest dynamics using integral projection models (IPMs) and repeat LiDAR
Rosen, A.; Battison, R.; Hernandez, C.; Spacey, O.; McLean, J.; Prober, S.; Gascoigne, S.; McMahon, S.; Jucker, T.; Salguero-Gomez, R.
10.1101/2025.01.06.631514 — ecology — Posted on 2025-01-08
4231 Pluripotent stem cell-derived NK progenitor cell therapy prevents tumour occurrence and eradicates minimal residual disease
Wang, Z.; Lin, Y.; Huang, D.; Zhang, L.; Xia, C.; Weng, Q.; Liu, Y.; Wang, T.; Zhang, M.; Wu, J.; Qi, H.; Liu, L.; Shen, Y.; Chen, Y.; Zhu, Y.; Hu, F.; Wang, J.
10.1101/2025.01.07.631650 — cancer biology — Posted on 2025-01-08
4232 TGFBR2-High mesenchymal glioma stem cells phenocopy regulatory T cells to suppress CD4+ and CD8+ T cell function
Johnson, A. L.; Khela, H. S.; Korleski, J.; Sall, S.; Li, Y.; Zhou, W.; Smith-Connor, K.; Lopez-Bertoni, H.; Laterra, J.
10.1101/2025.01.07.631757 — cancer biology — Posted on 2025-01-08
4233 Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in thetumor microenvironment
Aviles Huerta, D.; Del Pizzo, R.; Kowar, A.; Baig, A. H.; Palazzo, G.; Stepanova, E.; Amaya Ramirez, C. C.; D'Agostino, S.; Ratto, E.; Pechincha, C.; Siefert, N.; Engel, H.; Du, S.; Cardenas-De Miguel, S.; Miao, B.; Cruz Vilchez, V.; Muller-Decker, K.; Elia, I.; Sun, C.; Palm, W.; Loayza-Puch, F.
10.1101/2025.01.08.631877 — cancer biology — Posted on 2025-01-08
4234 Androgen receptor inhibition extends PARP inhibitor activity in prostate cancer models beyond BRCA mutations and defects in homologous recombination repair.
Illuzzi, G.; Galbiati, A.; Staniszewska, A. D.; Hanson, R.; Michaloglou, C.; Cooke, S.; Uznanska, K.; Bialecka, M.; Solarczyk, K.; Dev, H. S.; Massie, C. E.; Albertella, M. R.; Leo, E.; Forment, J. V.; O'Connor, M. J.
10.1101/2025.01.07.631700 — cancer biology — Posted on 2025-01-08
4235 Mitoxantrone inhibits and downregulates ERα through binding at the DBD-LBD interface
Wang, H.; Luo, Y.; Artham, S.; Wang, Q.; Peng, Y.; Yun, Z.; Li, X.; Wu, C.; Liu, Z.; Weber-Bonk, K. L.; Pai, C.-P.; Cao, Y.; Yue, J.; Park, S.; Keri, R. A.; Geng, L.; McDonnell, D. P.; Kao, H.-Y.; Yang, S.
10.1101/2025.01.07.631371 — cancer biology — Posted on 2025-01-08
4236 Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression
Guinn, S.; Perez, B.; Tandurella, J. A.; Ramani, M.; Lee, J. W.; Zabransky, D. J.; Kartalia, E.; Patel, J.; Zlomke, H.; Nicolson, N.; Shin, S.; Barrett, B.; Sun, N.; Hernandez, A.; Coyne, E.; Cannon, C.; Gross, N. E.; Charmsaz, S.; Cho, Y.; Leatherman, J.; Lyman, M.; Mitchell, J. T.; Kagohara, L. T.; Goggins, M. G.; Lafaro, K. J.; He, J.; Shubert, C.; Burns, W.; Zheng, L.; Fertig, E. J.; Jaffee, E. M.; Burkhart, R. A.; Ho, W. J.; Zimmerman, J. W.
10.1101/2025.01.07.631784 — cancer biology — Posted on 2025-01-08
4237 Convergent genomic and molecular features predict risk of metachronous metastasis in clear cell renal cell carcinoma
Naeini, M. M.; Pang, M.; Rohatgi, N.; Kadioglu, S.; Ghoshdastider, U.; DiNatale, R. G.; Mano, R.; Hakimi, A. A.; Skanderup, A. J.
10.1101/2025.01.07.630976 — cancer biology — Posted on 2025-01-08
4241 MLC1 alteration in iPSCs give rise to disease-like cellular vacuolation phenotype in the astrocyte lineage
Sharma, S.; Bharti, V.; Das, P. K.; Rahman, A.; Sharma, H.; Rauthan, R.; RC, M.; Gupta, N.; Shukla, R.; Mohanty, S.; Kabra, M.; Francis, K. R.; Chakraborty, D.
10.1101/2025.01.06.631607 — cell biology — Posted on 2025-01-08
4243 β1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium
Sakthivel, K.; Kotowska, A. M.; Portner, E. J.; Merry, C.; Nordenfelt, P. M.; Wright, A. J.; Swaminathan, V. S.
10.1101/2025.01.07.631639 — cell biology — Posted on 2025-01-08
4244 Mitigating Proinflammatory SASP and DAMP with Urolithin A: A Novel Senomorphic Strategy
Barkovskaya, A.; Brauning, A.; Chamoli, M.; Rane, A.; Andersen, J. K.; Sharma, A.
10.1101/2025.01.07.631588 — cell biology — Posted on 2025-01-08
4246 CellPhePy: a Python implementation of the CellPhe toolkit for automated cell phenotyping from microscopy time-lapse videos
Wiggins, L.; Lacy, S.; Park, G.; Marrison, J.; Powell, B.; Cimini, B. A.; O'Toole, P. J.; Wilson, J.; Brackenbury, W. J.
10.1101/2025.01.07.631669 — cell biology — Posted on 2025-01-08
4248 Redox homeostasis in ferroptosis and aging: a causal role for fard-1 and dhs-25 in Caenorhabditis elegans
Pensotti, R.; Sciandrone, B.; Bovio, F.; Schroeter, L.; Maglioni, S.; Thewes, L.; Forcella, M. E.; Fusi, P. A.; Rossi, A.; Berndt, C.; Ventura, N.; Regonesi, M. E. E.
10.1101/2025.01.07.631721 — cell biology — Posted on 2025-01-08
4249 Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome
Merino-Cacho, L.; Barroso-Gomila, O.; Pozo-Rodriguez, M.; Muratore, V.; Serrano, A.; Guinea-Perez, C.; Perez, C.; Cano-Lopez, S.; Urcullu, A.; Azkargorta, M.; Iloro, I.; Galdeano, C.; Juarez-Jimenez, J.; Mayor, U.; Elortza, F.; Barrio, R.; Sutherland, J. D.
10.1101/2025.01.07.631759 — cell biology — Posted on 2025-01-08
4253 Canonical Wnt induction by OTULIN prevents keratinocyte death and skin inflammation
Lecomte, K.; Hertens, P.; Toniolo, A.; Boone, F.; Ciers, M.; Verboom, L.; Staes, K.; van Loo, G.; Hoste, E.
10.1101/2025.01.08.631848 — cell biology — Posted on 2025-01-08
4254 Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution
Ong, Q.; Lim, C. J. Y.; Liao, Y.; Ng, J. T.-Y.; Lim, L. T. R.; Koh, S. X. Y.; Chan, S. E.; Lee, P. Y. Y.; Lim, H.; Ye, C. R.; Wang, L. C.; Ler, S. G.; Sobota, R. M.; Tan, Y. S.; I. Shulman, G.; Yang, X.; Han, W.
10.1101/2025.01.06.631444 — molecular biology — Posted on 2025-01-08
4256 Specificity Protein 1 is essential for the limb trajectory of ephrin-mediated spinal motor axons
Liao, P.; Chang, M.-Y.; Yang, W.-B.; Lin, K.; Lee, Y.-C.; Chuang, J.-Y.; Wu, Y.-H.; Kania, A.; Chang, W.-C.; Hsu, T.-I.; Kao, T.-J.
10.1101/2025.01.07.631735 — neuroscience — Posted on 2025-01-08
4257 Host genotype shapes root mycobiota in durum wheat
TRINQUIER, M.; COLOMBO, M.; FREVILLE, H.; JACQUES, D.; ROCHER, A.; LEFEBVRE, B.; ROUX, C.
10.1101/2024.10.27.616629 — plant biology — Posted on 2025-01-08
4258 Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training
Hulmi, J. J.; Halonen, E. J.; Sharples, A. P.; O'Connell, T. M.; Kuikka, L.; Lappi, V.-M.; Salokas, K.; Keskitalo, S.; Varjosalo, M.; Ahtiainen, J. P.
10.1101/2024.11.19.624068 — physiology — Posted on 2025-01-08
4259 Engineering 3D Skeletal Muscle Tissue with Complex Multipennate Myofiber Architectures
Stang, M. A.; Lee, A.; Bliley, J. M.; Coffin, B. D.; Yerneni, S. S.; Campbell, P. G.; Feinberg, A. W.
10.1101/2025.01.06.631119 — bioengineering — Posted on 2025-01-08
4260 Homosensory and heterosensory dishabituation engage distinct circuits in Drosophila
Charonitakis, A.; Pasadaki, S.; Georganta, E.-M.; Foka, K.; Semelidou, O.; Skoulakis, E. M.
10.1101/2025.01.07.631716 — animal behavior and cognition — Posted on 2025-01-08
4262 ANGPTL3 binds to PCSK9 to coordinately regulate intracellular lipid homeostasis.
Bini, S.; Pecce, V.; Pinzon Grimaldos, A.; Di Costanzo, A.; Minicocci, I.; Covino, S.; Tramontano, D.; Piconese, S.; D'Erasmo, L.; Arca, M.
10.1101/2025.01.05.631413 — cell biology — Posted on 2025-01-08
4263 CSDE1 regulates miR-20a-5p/ TMBIM6 axis in melanoma
Ramakrishna, S.; Guitart, T.; Gebauer, F.; Kakumani, P. K.
10.1101/2025.01.07.631786 — molecular biology — Posted on 2025-01-08
4266 WITHDRAWN: HER2 Cellular Localization, Cell-Cell Contacts, and Cell Density Regulate Cancer Cell Plasticity in HER2+ Breast Cancer
Sameri, S.; Das, D.; Shahrivari, S.; Milosevic, V.; Sarhadi, S.; Koerkel-Qu, H.; Fisch, C.; Kokal, M.; Schletter, M.; Hahn, P. S.; Seider, L.; Schubel, M.; Michaelis, S.; Wegener, J.; Weber, F.; Hoffmann, M.; Werno, C.; Weidele, K.; Bruckmann, A.; Ostman, A.; Tamm, E. R.; Li, Y.; Klein, C. A.; Hosseini, H.
10.1101/2023.09.28.559965 — cancer biology — Posted on 2025-01-08
4268 Cell-death induced immune response and coagulopathy promote cachexia in Drosophila
Singh, A.; Hu, Y.; Lopes, R. F.; Lane, L.; Woldemichael, H.; Xu, C.; Udeshi, N.; Carr, S. A.; Perrimon, N.
10.1101/2025.01.07.631515 — genetics — Posted on 2025-01-08
4269 Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control
Rodschinka, G.; Forcelloni, S.; Behrens, A.; Riemenschneider, H.; Edbauer, D.; Wani, S.; Nedialkova, D. D.
10.1101/2025.01.07.631643 — molecular biology — Posted on 2025-01-08
4270 Polymerase Eta Recruits FANCD2 to Common Fragile Sites to Maintain Genome Stability
Niljikar, M.; Barreto-Galvez, A.; Patel, S.; Gagliardi, J. E.; Kumar, V.; Pradeep, A.; Juwarwala, A.; Gerhardt, J.; Chang, Y.; Montagna, C.; Madireddy, A.
10.1101/2025.01.06.631600 — molecular biology — Posted on 2025-01-08
4271 Adipocyte Aldosterone in Obstructive Sleep Apnea
Dong, Y.; Bock, J. M.; Karim, S.; Singh, P.; Somers, V. K.
10.1101/2025.01.07.631499 — molecular biology — Posted on 2025-01-08
4275 Engineered bacteria launch and control an oncolytic virus
Singer, Z. S.; Pabon, J.; Huang, H.; Sun, W.; Luo, H.; Grant, K.; Coker, C.; Rice, C. M.; Danino, T.
10.1101/2023.09.28.559873 — synthetic biology — Posted on 2025-01-08
4278 Fast and flexible minimizer digestion with digest
Zheng, A.; Lee, I.; Shivakumar, V. S.; Ahmed, O. S.; Langmead, B.
10.1101/2025.01.02.631161 — bioinformatics — Posted on 2025-01-08
4279 AAVone: A Cost-Effective, Single-Plasmid Solution for Efficient AAV Production with Reduced DNA Impurities
Yang, R.; Tran, N. T.; Chen, T.; Cui, M.; Wang, Y.; Sharma, T.; Liu, Y.; Zhang, J.; Yuan, X.; Zhang, D.; Chen, C.; Shi, Z.; Wang, L.; Dai, Y.; Zaidi, H.; Liang, J.; Chen, M.; Jaijyan, D.; Hu, H.; Wang, B.; Xu, C.; Hu, W.; Gao, G.; Yu, D.; Tai, P. W. L.; Wang, Q.
10.1101/2025.01.07.631712 — bioengineering — Posted on 2025-01-08
4281 TRIM21-NUP98 interface accommodates structurally diverse molecular glue degraders
Han, T.; Cheng, Y.; Cao, L.; Lu, P.; Xue, L.; Li, X.; Wang, Q.; Dou, D.; Li, J.
10.1101/2025.01.07.631691 — biochemistry — Posted on 2025-01-08
4283 Structural insights into heterohexameric assembly of epilepsy-related ligand-receptor complex LGI1-ADAM22
Yamaguchi, T.; Okatsu, K.; Kubota, M.; Mitsumori, A.; Yamagata, A.; Fukata, Y.; Fukata, M.; Shibata, M.; Fukai, S.
10.1101/2025.01.06.631603 — biochemistry — Posted on 2025-01-08
4284 Nucleotide-resolution Mapping of RNA N6-Methyladenosine (m6A) modifications and comprehensive analysis of global polyadenylation events in mRNA 3' end processing in malaria pathogen Plasmodium falciparum
Catacalos-Goad, C.; Chakrabarti, M.; Salem, D. H.; Camporeale, C.; Somalraju, S.; Tegowski, M.; Singh, R.; Reid, R. W.; Janies, D. A.; Meyer, K. D.; Janga, S. C.; Hunt, A. G.; Chakrabarti, K.
10.1101/2025.01.07.631827 — genomics — Posted on 2025-01-08
4286 Pluripotency factors enhance the firing efficiency of late DNA replication origins in mouse embryonic stem cells
Rodriguez-Carballo, E.; Dionellis, V. S.; Ntallis, S. G.; Bernasconi, L.; Keskin, E.; Halazonetis, T.
10.1101/2025.01.07.631761 — molecular biology — Posted on 2025-01-08
4290 Metabolic tagging reveals surface-associated lipoproteins in mycobacteria
Parkin, L. A.; Maceren, J. P.; Palande, A.; Previti, M. L.; Seeliger, J. C.
10.1101/2025.01.07.631728 — microbiology — Posted on 2025-01-08
4291 Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization.
Tang, G.; Carr, A. V.; Perez, C.; Ramos Sarmiento, K.; Levy, L.; Lampe, J.; Diener, C.; Gibbons, S. M.
10.1101/2025.01.07.631807 — microbiology — Posted on 2025-01-08
4293 Isolation of phages infecting the zoonotic pathogen Streptococcus suis reveals novel structural and genomic characteristics
Osei, E. K.; O'Hea, R.; Cambillau, C.; Athalye, A.; Hille, F.; Franz, C. M. A. P.; O'Doherty, A.; Wilson, M.; Murray, G. G. R.; Weinert, L. A.; Manzanilla, E. G.; Mahony, J.; Kenny, J.
10.1101/2025.01.07.631744 — microbiology — Posted on 2025-01-08
4294 Targeting histone acetylation to overcome drug resistance in the parasite Trichomonas vaginalis
Seifert-Gorzycki, J.; Munoz, D.; Lizarraga, A.; Iriarte, L.; Coceres, V.; Strobl-Mazzulla, P. H.; de Miguel, N.
10.1101/2025.01.07.631743 — microbiology — Posted on 2025-01-08
4299 Diverse ssRNA viruses associated with Karenia brevis harmful algal blooms in Southwest Florida
Lim, S. J.; Rogers, A.; Rosario, K.; Kerr, M.; Garrett, M.; Koester, J.; Hubbard, K.; Breitbart, M.
10.1101/2025.01.06.631608 — microbiology — Posted on 2025-01-08
4300 Abundant and active acetogens enhance the carbon dioxide sink of Blue Carbon ecosystems
Rodriguez Martinez, K.; Ricci, F.; Ni, G.; Iram, N.; Palfreyman, R.; Gonzalez-Garcia, R. A.; Heffernan, J. K.; Greening, C.; Adame, M. F.; Marcellin, E.
10.1101/2025.01.07.631696 — microbiology — Posted on 2025-01-08
4303 Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals to navigate soil
Kulich, I.; Vladimirtsev, D.; Randuch, M.; Gao, S.; Citterico, M.; Konrad, K.; Nagel, G.; Wrzaczek, M.; Friml, J.
10.1101/2025.01.07.631646 — plant biology — Posted on 2025-01-08
4305 Higher adaxial stomatal density is associated with lower grain yield in spring wheat
Samantara, K.; Ivandi, E.; Tulva, I.; Jalakas, P.; Khalegh Doust, B.; Ingver, A.; Karp, M.; Brazauskas, G.; Bleidere, M.; Tamm, I.; Horak, H.; Merilo, E.
10.1101/2025.01.07.631641 — plant biology — Posted on 2025-01-08
4309 Densely Populated Cell and Organelles Segmentation with U-Net Ensembles
Fulton, S.; Baenen, C.; Storrie, B.; Yang, Z.; Leapman, R. D.; Aronova, M.
10.1101/2024.11.19.623228 — bioengineering — Posted on 2025-01-08
4310 Steppe Ancestry in western Eurasia and the spread of the Germanic Languages
McColl, H.; Kroonen, G.; Moreno-Mayar, J. V.; Valeur Seersholm, F.; Scorrano, G.; Pinotti, T.; Vimala, T.; Sindbaek, S. M.; Ethelberg, P.; Fyfe, R.; Gaillard, M.-J.; Larsen, H. M. E.; Mortensen, M. F.; Demeter, F.; Jorkov, M. L. S.; Bergerbrant, S.; Damgaard, P. d. B.; Allentoft, M. E.; Vinner, L.; Gaunitz, C.; Ramsoe, A.; Altinkaya, I.; Amund Henriksen, R.; Irving-Pease, E. K.; Sjögren, K.; Sabatini, S.; Fischer, A.; Barrie, W.; Ingason, A.; Rosengren, A.; Vaughn, A.; Cao, J.; Staring, J.; Stenderup, J.; Yediay, F. E.; Ahlström, T.; Akhvlediani, I.; Albris, S. L.; Atabiev, B.; Balanovskaya,
10.1101/2024.03.13.584607 — genetics — Posted on 2025-01-07
4314 An improved rapid and sensitive long amplicon method for nanopore-based RSV whole genome sequencing
Dong, X.; Edwards, S.; Deng, Y.-M.; Dapat, C.; Hirankitti, A.; Wordsworth, R.; Whitney, P.; Baird, R.; Freeman, K.; Daley, A. J.; Barr, I. G.
10.1101/2025.01.06.631406 — microbiology — Posted on 2025-01-07
4316 Selective direct motor cortical influence during naturalistic climbing in mice
Koh, N.; Ma, Z.; Sarup, A.; Kristl, A. C.; Agrios, M.; Young, M.; Miri, A.
10.1101/2023.06.18.545509 — neuroscience — Posted on 2025-01-07
4319 Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs
Yoshino, J.; Mali, S.; Williams, C.; Morita, T.; Emerson, C.; Arp, C.; Miller, S.; Yin, C.; The, L.; Chikaya, H.; Motoyoshi, M.; Ishii, K.; Emoto, K.; Bautista, D. M.; Parrish, J. Z.
10.1101/2022.10.07.511265 — neuroscience — Posted on 2025-01-07
4321 NFIB influences progenitor competence in maturation of GABAergic neurons in mice
Bright, A. R.; Kotlyarenko, Y.; Neuhaus, F.; Rodrigues, D.; Feng, C.; Peters, C.; Vitali, I.; Doenmez, E.; Myoga, M. H.; Dvoretskova, E.; Mayer, C.
10.1101/2024.03.18.585524 — neuroscience — Posted on 2025-01-08
4324 Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons
Strucinska, K.; Kneis, P.; Pennington, T.; Cizio, K.; Szybowska, P.; Morgan, A.; Weertman, J.; Lewis, T. L.
10.1101/2025.01.07.631801 — cell biology — Posted on 2025-01-07
4327 Human cortical dynamics reflect graded contributions of local geometry and network topography
Royer, J.; Paquola, C.; Rodriguez-Cruces, R.; Auer, H.; Ngo, A.; Sahlas, E.; Arafat, T.; Abdallah, C.; Mansilla de Latorre, D.; Pana, R.; Hall, J. A.; Leech, R.; Smallwood, J.; Frauscher, B.; Bernhardt, B.
10.1101/2025.01.07.631564 — neuroscience — Posted on 2025-01-07
4329 Light and chloroplast redox state modulate the progression of tobacco leaf infection by Pseudomonas syringae pv tabaci
Arce, R. C.; Demarchi, M.; Figueroa, N.; Delprato, M. L.; Hajirezaei, M.-R.; Mayta, M. L.; Lodeyro, A. F.; Krapp, A. D. R.; Carrillo, N.
10.1101/2025.01.06.631282 — plant biology — Posted on 2025-01-07
4332 Quantifying Metagenomic Strain Associations fromMicrobiomes with Anpan
Ghazi, A. R.; Thompson, K. N.; Bhosle, A.; Mei, Z.; Yan, Y.; Wang, F.; Wang, K.; Franzosa, E. A.; Huttenhower, C.
10.1101/2025.01.06.631550 — bioinformatics — Posted on 2025-01-07
4333 Deep Learning for Biomarker Discovery in Cancer Genomes
Unger, M.; Loeffler, C. M. L.; Zigutyte, L.; Sainath, S.; Lenz, T.; Vibert, J.; Mock, A.; Froehling, S.; Graham, T. A.; Carrero, Z. I.; Kather, J. N.
10.1101/2025.01.06.631471 — bioinformatics — Posted on 2025-01-07
4334 A comprehensive benchmark and guide for sequence-function interpretable deep learning models in genomics
Sun, C.; Sun, Y.; Xu, K.; He, Z.; Li, H.; Li, Y.; Yu, Z.; wang, Y.; Lin, X.; Xu, X.; Hu, P.; Bo, X.; Liao, M.; Chen, H.
10.1101/2025.01.06.631405 — bioinformatics — Posted on 2025-01-07
4335 Discovery of Expression-Governing Residues in Proteins
Jiang, F.; Li, M.; Wu, B.; Zhang, L.; Zhong, B.; Yu, Y.; Hong, L.
10.1101/2025.01.06.631498 — bioengineering — Posted on 2025-01-07
4337 Detailed tandem repeat allele profiling in 1,027 long-read genomes reveals genome-wide patterns of pathogenicity
Danzi, M. C.; Xu, I. R. L.; Fazal, S.; Dolzhenko, E.; Pellerin, D.; Weisburd, B.; Reuter, C.; Sampson, J.; Folland, C.; Wheeler, M. T.; O'Donnell-Luria, A.; Wuchty, S.; Ravenscroft, G.; Eberle, M. A.; All of Us Research Program Long Read Working Group, ; Zuchner, S.
10.1101/2025.01.06.631535 — genomics — Posted on 2025-01-07
4338 EASYstrata: a new workflow to infer evolutionary strata along sex chromosomes and other supergenes
Rougemont, Q.; Lucotte, E.; Boyer, L.; Jalaber, A.; Snirc, A.; Giraud, T.; Rodriguez de la Vega, R. C.
10.1101/2025.01.06.631483 — genomics — Posted on 2025-01-07
4339 Signatures of genomic adaptation to Cuckoo brood parasitism in Reed Warbler hosts across Europe
Smith, W. J.; Ronka, K.; Bensch, S.; Bergman, N.; Dudaniec, R. Y.; Eroukhmanoff, F.; Fossoy, F.; Hansson, B.; Jezierski, M. T.; Kluen, E.; Prochazka, P.; Lo Cascio Saetre, C.; Stokke, B. G.; Thorogood, R.
10.1101/2025.01.06.631542 — evolutionary biology — Posted on 2025-01-07
4342 Virus and Cell Specific HMGB1 Secretion and Subepithelial Infiltrate Formation in Adenovirus Keratitis
Saha, A.; Islam, M. M.; Kumar, R.; Ismail, A. M.; Garcia, E.; Gullapali, R. R.; Chodosh, J.; Rajaiya, J.
10.1101/2025.01.07.631509 — microbiology — Posted on 2025-01-07
4343 Prolific release of S-layer units and associated proteins by the methanotrophic bacterium Methylomicrobium album BG8
Hermary, M. K.; Rodriguez Gallo, M. C.; Grigonyte, A. M.; Uhrig, R. G.; Sauvageau, D.; Stein, L. Y.
10.1101/2025.01.06.631565 — microbiology — Posted on 2025-01-07
4346 Determination of the mechanisms of MCPA resistance in Amaranthus powellii
Aicklen, I.; Jugulam, M.; Gaines, T. A.; Kramer, W.; Laforest, M.; Robinson, D.; Sikkema, P.; Tardif, F.
10.1101/2025.01.03.631130 — plant biology — Posted on 2025-01-07
4347 Armadillo Repeat Only Proteins Are Crucial for the Function of Plant CNGC Channels
Kulich, I.; Oulehlova, D.; Vladimirtsev, D.; Zou, M.; Lileikyte, E.; Janda, M.; Iakovenko, O.; Neubergerova, M.; Studtrucker, T.; Pleskot, R.; Dietrich, P.; Fendrych, M.; Friml, J.
10.1101/2025.01.06.631460 — plant biology — Posted on 2025-01-07
4351 Queen loss unmasks cryptic worker influence and decentralizes the bumble bee social network
Ruttenberg, D. M.; Wolf, S. W.; Webb, A. E.; Wyman, E. S.; White, M.; Melo, D.; Traniello, I. M.; Kocher, S. D.
10.1101/2025.01.07.630106 — animal behavior and cognition — Posted on 2025-01-07
4353 The Chimeric Peptide (GEP44) Reduces Body Weight, Energy Intake, and Energy Expenditure in Diet-Induced Obese Rats
Goldberg, M. E.; Blevins, J. E.; Wolden-Hanson, T.; Elfers, C. T.; Chichura, K. S.; Ashlaw, E. F.; den Hartigh, L. J.; Roth, C. L.; Doyle, R. P.
10.1101/2025.01.06.631534 — physiology — Posted on 2025-01-07
4355 Necrotizing enterocolitis causes increased ileal goblet cell loss in Wnt2b KO mice
Adegboye, C.; Emeonye, C.; Wu, Y.-S.; Oliveira, F. L. S.; Raveenthiraraj, S.; O'Connell, A. E.
10.1101/2025.01.07.631715 — developmental biology — Posted on 2025-01-07
4356 Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
Zurawska, G.; Sas, Z.; Jonczy, A.; Mahadeva, R.; Slusarczyk, P.; Chwalek, M.; Seehofer, D.; Damm, G.; Kulecka, M.; Rumienczyk, I.; Moulin, M.; Jastrzebski, K.; Mikula, M.; Etzerodt, A.; Serwa, R.; Miaczynska, M.; Rygiel, T. P.; Mleczko-Sanecka, K.
10.1101/2023.11.14.566925 — cell biology — Posted on 2025-01-07
4358 WormID-Benchmark: Extracting Whole-Brain Neural Dynamics of C. elegans At the Neuron Resolution
Adhinarta, J.; Dong, J.; He, T.; Sprague, D.; Wan, J.; Lee, H. J.; Yu, Z.; Lu, H.; Yemini, E.; Kato, S.; Varol, E.; Wei, D.
10.1101/2025.01.06.631621 — neuroscience — Posted on 2025-01-07
4359 HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell Renal Cell Carcinoma
Zhao, W.; Kim, B.; Coffey, N. J.; Bowers, S.; Jiang, Y.; Bowman, C. E.; Noji, M.; Jang, C.; Simon, C. M.; Arany, Z.; Kim, B.
10.1101/2024.05.04.592520 — cancer biology — Posted on 2025-01-07
4363 A computationally designed panel of diverse and selective peroxygenases for terpene oxyfunctionalization
Munch, J.; Soler, J.; Gildor-Cristal, O.; Fleishman, S.; Garcia-Borras, M.; Weissenborn, M. J.
10.1101/2024.09.27.615329 — biochemistry — Posted on 2025-01-07
4364 Targeted protein editing with an antibody-based system
Rimon, O.; Konc, J.; Ali, M.; Roy Chowdhury, V.; Cernauskiene, I.; Sormanni, P.; Bernardes, G. J. L.; Vendruscolo, M.
10.1101/2023.07.28.551006 — biochemistry — Posted on 2025-01-07
4365 Homosensory and heterosensory dishabituation engage distinct circuits in Drosophila
Charonitakis, A.; Pasadaki, S.; Georganta, E.-M.; Foka, K.; Semelidou, O.; Skoulakis, E. M.
10.1101/2025.01.07.631716 — animal behavior and cognition — Posted on 2025-01-07
4371 Loss of Elp3 impairs the maturation tempo of brain ependymal cells
Tielens, S.; Boutin, C.; Huysseune, S.; Thelen, N.; Charlet-Briart, M.; Reyskens, C.; Oskera, L.; Boutsen, A.; Mateo-Sanchez, S.; Delacroix, L.; Labedan, P.; Thiry, M.; Malgrange, B.; Chariot, A.; Tissir, F.; Creppe, C.; Seuntjens, E.; Laguesse, S.; Nguyen, L.
10.1101/2025.01.07.631730 — neuroscience — Posted on 2025-01-07
4372 Using magnetoencephalography to track the propagation of 40 Hz invisible spectral flicker
Henney, M. A.; Spaak, E.; Hansen, H. E.; Carstensen, M.; Madsen, K. H.; Oostenveld, R.
10.1101/2025.01.07.631693 — neuroscience — Posted on 2025-01-07
4373 Stress, Epigenetic Remodeling and FKBP51: Pathways to Chronic Pain Vulnerability
Morgan, O. B.; Singleton, S.; Hestehave, S.; Sarter, T.; Wozniak, E.; Mein, C. A.; Hausch, F.; Bell, C. G.; Geranton, S. M.
10.1101/2025.01.07.631709 — neuroscience — Posted on 2025-01-07
4376 Chromatin architecture mapping by multiplex proximity tagging
Delamarre, A.; Bailey, B.; Yavid, J.; Koche, R.; Mohibullah, N.; Whitehouse, I.
10.1101/2024.11.12.623258 — molecular biology — Posted on 2025-01-07
4377 Developmental olfactory dysfunction and abnormal odor memory in immune-challenged Disc1+/- mice
Parbst, F.; Kostka, J. K.; Gunther, A.; Chen, Y.-N.; Hanganu-Opatz, I. L. H.; Bitzenhofer, S. H.
10.1101/2024.05.17.594663 — neuroscience — Posted on 2025-01-07
4378 Long term rescue of Alzheimer deficits in vivo by one-time gene-editing of App C-terminus.
Aulston, B.; Gimse, K.; Bazick, H. O.; Kramar, E. A.; Pizzo, D. P.; Parra-Rivas, L. A.; Sun, J.; Branes-Guerrero, K.; Checka, N.; Bagheri, N.; Satyadev, N.; Carlson-Stevermer, J.; Saito, T.; Saido, T. C.; Audhya, A.; Wood, M. A.; Zylka, M. J.; Saha, K.; Roy, S.
10.1101/2024.06.08.598099 — neuroscience — Posted on 2025-01-07
4379 Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington's Disease Mouse Models
Pearl, J. R.; Shetty, A. C.; Cantle, J. P.; Bergey, D. E.; Bragg, R. M.; Coffey, S. R.; Kordasiewicz, H. B.; Hood, L. E.; Price, N. D.; Ament, S. A.; Carroll, J. B.
10.1101/2020.06.04.132571 — neuroscience — Posted on 2025-01-07
4380 Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury
Truchi, M.; Gautier-Isola, M.; Savary, G.; Cadis, H.; Scribe, C.; Baeri, A.; Lingampally, A.; Magnone, V.; Girard-Riboulleau, C.; Arguel, M.-J.; de Schutter, C.; Fassy, J.; Boukrout, N.; Larrue, R.; Martin, N.; Rezzonico, R.; Pluquet, O.; Perrais, M.; Hofman, V.; Marquette, C.-H.; Hofman, P.; Günther, A.; Ricard, N.; BARBRY, P.; Leroy, S.; Lebrigand, K.; Bellusci, S.; Cauffiez, C.; Vassaux, G.; Pottier, N.; Mari, B.
10.1101/2023.07.11.548522 — pathology — Posted on 2025-01-07
4381 Estimating consensus proteomes and metabolic functions from taxonomic affiliations
Belcour, A.; Hamon-Giraud, P.; Mataigne, A.; Ruiz, B.; Le Cunff, Y.; Got, J.; Awhangbo, L.; Lebreton, M.; Frioux, C.; Dittami, S.; Dabert, P.; Siegel, A.; Blanquart, S.
10.1101/2022.03.16.484574 — bioinformatics — Posted on 2025-01-07
4382 Lipid transfer proteins and a PI 4-kinase initiate nuclear phosphoinositide signaling
Carrillo, N. D.; Chen, M.; Wen, T.; Awasthi, P.; Wolfe, T. J.; Sterling, C.; Cryns, V. L.; Anderson, R. A.
10.1101/2023.05.08.539894 — cell biology — Posted on 2025-01-07
4386 In vivo regulation of an endogenously-tagged protein by a light-regulated kinase
vigano, a. m.; Bao, M.; Lepeta, K. J.; Aguilar, G.; Schnider, S. T.; Affolter, M.
10.1101/2024.11.27.625702 — developmental biology — Posted on 2025-01-07
4389 ABHD2 activity is not required for the non-genomic action of progesterone on human sperm
Arnolds, O.; Carter, E. M.; Edwards, M.; Wigren, E.; Homan, E.; Ribera, P.; Bentley, K.; Haraldsson, M.; Theo-Emegano, N.; Loppnau, P.; Szewczyk, M. M.; Cao, M. A.; Barsyte-Lovejoy, D.; Vester, K.; Thrun, A.; Amaral, A.; Lesche, R.; Münchow, J.; Zhu, W. F.; Temme, L.; Brenker, C.; Strünker, T.; Sundström, M.; Todd, M. H.; Edwards, A. M.; Tredup, C.; Gileadi, O.
10.1101/2024.12.17.628646 — cell biology — Posted on 2025-01-07
4390 Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants
Kiu, R.; Darby, E. M.; Alcon-Giner, C.; Acuna-Gonzalez, A.; Camargo, A.; Lamberte, L. E.; Phillips, S.; Sim, K.; Shaw, A. G.; Clarke, P.; van Schaik, W.; Kroll, J. S.; Hall, L. J.
10.1101/2024.12.18.629205 — microbiology — Posted on 2025-01-07
4391 Rac1 inhibition prevents axonal cytoskeleton dysfunction in Transthyretin Amyloid Polyneuropathy
Magalhaes, J.; Dias, V.; Eira, J.; Novoa, G.; Oliveira da Silva, M. I.; Kan, Y. Y.; Dias, A.; Carvalho, E.; Santos, M.; Seixas, A. I.; Coelho, T.; Taipa, R.; Paes de Faria, J. I.; Lemos, C.; Liz, M. A.
10.1101/2024.11.27.625664 — neuroscience — Posted on 2025-01-07
4392 Escalating High-dimensional Imaging using Combinatorial Channel Multiplexing and Deep Learning
Ben-Uri, R.; Ben Shabat, L.; Bar-Tal, O.; Bussi, Y.; Maimon, N.; Keidar Haran, T.; Milo, I.; Elhanani, O.; Rochwarger, A.; Schürch, C. M.; Bagon, S.; Keren, L.
10.1101/2023.09.09.556962 — systems biology — Posted on 2025-01-07
4393 Dynamic Transcriptomic Remodeling in Human Neural Progenitor Cells Reveals Mechanisms for Vision Preservation in Retinitis Pigmentosa Model
Shahin, S.; Bell, S.; Lu, B.; Banerjee, S.; Swarup, V.; Xu, H.; Chetsawang, J.; Ramirez, S.; Alfaro, J. S.; Laperle, A.; Svendsen, S.; Svendsen, C. N.; Wang, S.
10.1101/2025.01.06.631620 — neuroscience — Posted on 2025-01-07
4394 Biphasic Changes in Hippocampal Granule Cells after Traumatic Brain Injury
Danielewicz, J.; Llamosas, N.; Dura, I.; Barros de Souza, D.; Rodrigues, S.; Encinas, J. M.; Mateos, D. M.
10.1101/2024.01.23.576807 — neuroscience — Posted on 2025-01-07
4395 Intrastriatal delivery of a zinc finger protein targeting the mutant HTT gene obviates lipid phenotypes in zQ175DN HD mice
Iwanowicz, A.; Boudi, A.; Seeley, C.; Sapp, E.; Miller, R.; Liu, S.; Chase, K.; Shing, K.; Batista, A. R.; Siena-Esteves, M.; Aronin, N.; Difiglia, M.; Kegel-Gleason, K. B.
10.1101/2025.01.06.630918 — neuroscience — Posted on 2025-01-07
4396 Attentional cueing effects are reversed during locomotion
Djebbara, Z.; Huynh, D. C.; Koselevs, A.; Chen, Y.; Fich, L. B.; Gramann, K.
10.1101/2025.01.07.631651 — neuroscience — Posted on 2025-01-07
4397 NF1 modulates microtubule repair and sensitivity to antibody-drug conjugates
Achutti Duso, B.; Messuti, E.; Tini, G.; Bonetti, E.; Castiglioni, A.; Frige, G.; Ciossani, G.; Monzani, S.; Soriani, C.; Khuntsariya, D.; Roda, N.; Polazzi, A.; Ippolito, M. R.; Gavilan Dorronzoro, E.; Mane, E.; Milani, M.; Bottosso, M.; Pagliuca, M.; Farfalla, A.; Dondi, A.; Nicolo, E.; Reduzzi, C.; Jemos, C.; Guerini Rocco, E.; Rodighero, S.; Tosoni, D.; Medford, A.; Davis, A.; D'Amico, P.; Santaguida, S.; Cristofanilli, M.; Braun, M.; Lansky, Z.; Scietti, L. A.; Pelicci, P. G.; Mazzarella, L.
10.1101/2023.12.06.569572 — cancer biology — Posted on 2025-01-07
4398 Demonstrating Soft X-Ray Tomography in the lab for correlative cryogenic biological imaging using X-rays and light microscopy
O'Connor, S.; Rogers, D.; Kobylynska, M.; Geraets, J.; Thaysen, K.; Egebjerg, J. M.; Brink, M. C.; Herbsleb, L.; Salakova, M.; Fuchs, L.; Alves, F.; Feldmann, C.; Ekman, A.; Sheridan, P.; Fyans, W.; McEnroe, T.; O'Reilly, F.; Fahy, K.; Fleck, R. A.; Wüstner, D.; Simpson, J. C.; Walter, A.; Kapishnikov, S.
10.1101/2024.12.23.629889 — biophysics — Posted on 2025-01-07
4399 HapCNV: A Comprehensive Framework for CNV Detection in Low-input DNA Sequencing Data
Yu, X.; Qin, F.; Liu, S.; Brown, N. J.; Lu, Q.; Cai, G.; Guler, J. L.; Xiao, F.
10.1101/2024.12.19.629494 — bioinformatics — Posted on 2025-01-07
4400 Sheltered load in fungal mating-type chromosomes revealed by fitness experiments
Guyot, L.; Chahine, E.; De Filippo, E.; Lalanne, C.; Brun, S.; Hartmann, F. E.; Giraud, T.
10.1101/2024.09.10.612177 — evolutionary biology — Posted on 2025-01-07
4402 In vivo measurements of receptor tyrosine kinase activity reveal feedback regulation of a developmental gradient
Ho, E. K.; Kim-Yip, R. P.; Simpkins, A. G.; Farahani, P. E.; Oatman, H. R.; Posfai, E.; Shvartsman, S. Y.; Toettcher, J. E.
10.1101/2025.01.06.631605 — developmental biology — Posted on 2025-01-07
4403 Drosophila Toll-2 controls homeotic domain formation and timing of folding
Alpar, L.; Pigache, R.; Leroy, A.; Ech-Chouini, M.; Pelletier, S.; Bellaiche, Y.
10.1101/2025.01.07.631521 — developmental biology — Posted on 2025-01-07
4406 Evidence for direct control of neurovascular function by circulating platelets in healthy older adults
Rossetti, G. M. K.; Dunster, J. L.; Sohail, A.; Williams, B.; Cox, K. M.; Jewett, E.; Benford, E.; Lovegrove, J. A.; Gibbins, J. M.; Christakou, A.
10.1101/2024.05.31.596788 — neuroscience — Posted on 2025-01-07
4408 Early amyloid spine response and impaired synaptic transmission of pyramidal neurons in human biopsies with Alzheimer's Disease-related pathology
Dougalis, A.; Abushik, P.; Pelkonen, A.; Giudice, L.; Gomez-Budia, M.; Novosolova, N.; Valimaki, N.-N.; Rezaie, M.; Nurkhametova, D.; Giniatullina, R.; Shakirzyanova, A.; Mali, A.; Rauramaa, T.; Stevens, B.; Hiltunen, M.; Leinonen, V.; Malm, T.
10.1101/2025.01.07.630516 — neuroscience — Posted on 2025-01-07
4410 Noncanonical Short-Latency Auditory Pathway Directly Activates Deep Cortical Layers
Garcia, M. M.; Kline, A. M.; Onodera, K.; Tsukano, H.; Dandu, P. R.; Acosta, H. C.; Kasten, M.; Manis, P. B.; Kato, H. K.
10.1101/2025.01.06.631598 — neuroscience — Posted on 2025-01-07
4412 Dorsal hippocampus mediates light-tone sensory preconditioning task in mice
Pinho, J. S.; Ramon-Duaso, C.; Manzanares-Sierra, I.; Busquets-Garcia, A.
10.1101/2025.01.07.631667 — neuroscience — Posted on 2025-01-07
4413 WormID-Benchmark: Extracting Whole-Brain Neural Dynamics of C. elegans At the Neuron Resolution
Adhinarta, J.; Dong, J.; He, T.; Sprague, D.; Wan, J.; Lee, H. J.; Yu, Z.; Lu, H.; Yemini, E.; Kato, S.; Varol, E.; Wei, D.
10.1101/2025.01.06.631621 — neuroscience — Posted on 2025-01-07
4415 Endocannabinoids facilitate transitory reward engagement through retrograde gain control
Marcus, D. J.; English, A. E.; Chun, G.; Seth, E. F.; Oomen, R.; Hwang, S.; Wells, B. A.; Piantadosi, S. C.; Suko, A.; Li, Y.; Zweifel, L.; Land, B. B.; Stella, N.; Bruchas, M.
10.1101/2025.01.06.630792 — neuroscience — Posted on 2025-01-07
4416 Transcriptional responses to prolonged oxidative stress require cholinergic activation of G-protein-coupled receptor signaling
Biswas, K.; Moore, C.; Rogers, H.; Wani, K. A.; Higgins, D. P.; Walker, A. K.; Pukkila-Worley, R.; Rand, J. B.; Francis, M. M.
10.1101/2025.01.06.628021 — neuroscience — Posted on 2025-01-07
4418 Integration of multi-omics and deep phenotyping provides novel insights into multiple abiotic stress responses in potato
Zagorscak, M.; Abdelhakim, L.; Rodriguez-Granados, N. Y.; Siroka, J.; Ghatak, A.; Bleker, C.; Blejec, A.; Zrimec, J.; Novac, O.; Pencik, A.; Baebler, S.; Borroto, L. P.; Schuy, C.; Zupanic, A.; Afjehi-Sadat, L.; Wurzinger, B.; Weckwerth, W.; Pompe-Novak, M.; Knight, M. R.; Strnad, M.; Bachem, C. W.; Chaturvedi, P.; Sonnewald, S.; Sasidharan, R.; Panzarova, K.; Gruden, K.; Teige, M.
10.1101/2024.07.18.604140 — plant biology — Posted on 2025-01-07
4419 Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres
Freire, N. H.; Herlinger, A. L.; Vanini, J.; Dalmolin, M.; Fernandes, M. A. C.; Nor, C.; Ramaswamy, V.; de Farias, C. B.; Brunetto, A. T.; Brunetto, A. L.; Gregianin, L. J.; Jaeger, M. d. C.; Taylor, M. D.; Roesler, R.
10.1101/2024.09.23.614476 — cancer biology — Posted on 2025-01-07
4422 Benchmarking AI Models for In Silico Gene Perturbation of Cells
Li, C.; Gao, H.; She, Y.; Bian, H.; Chen, Q.; Liu, K.; Wei, L.; Zhang, X.
10.1101/2024.12.20.629581 — bioinformatics — Posted on 2025-01-07
4423 Toward De Novo Protein Design from Natural Language
Dai, F.; Fan, Y.; Su, J.; Wang, C.; Han, C.; Zhou, X.; Liu, J.; Qian, H.; Wang, S.; Zeng, A.; Wang, Y.; Yuan, F.
10.1101/2024.08.01.606258 — bioengineering — Posted on 2025-01-07
4424 PI(3,5)P2 Controls the Signaling Activity of Class I PI3K
Sun, J.; Zalejski, J.; Song, S.; Sharma, A.; Wang, W.; Hu, Y.; Lo, W.-T.; Koch, P.; Singh, J.; Singaram, I.; An, B.; Zhao, J.; Gong, L.-W.; Haucke, V.; Gao, R.; Cho, W.
10.1101/2023.01.25.525550 — biochemistry — Posted on 2025-01-07
4428 Strong Selection, but low repeatability: Temperature-specific effects on genomic predictions of adaptation
Rego, A.; Baur, J.; Girard-Tercieux, C.; de la Paz Celorio-Mancera, M.; Stelkens, R.; Berger, D.
10.1101/2024.09.12.612579 — evolutionary biology — Posted on 2025-01-07
4429 Functional carbohydrate-active enzymes acquired by horizontal gene transfer from plants in the whitefly Bemisia tabaci
Colinet, D.; Haon, M.; Drula, E.; Boyer, M.; Grisel, S.; Belliardo, C.; Koutsovoulos, G.; Berrin, J.-G.; Danchin, E.
10.1101/2024.06.03.597214 — evolutionary biology — Posted on 2025-01-07
4430 ARHGEF18 is a flow-responding exchange factor controlling endothelial tight junctions and vascular leakage
Batta, S. P. R.; Rio, M.; Lebot, C.; Baron-Menguy, C.; Babahnini, i.; Bodet, M.; Le Ruz, R.; Loirand, G.; Vion, A.-C.
10.1101/2022.09.10.507283 — cell biology — Posted on 2025-01-07
4432 MAIT cells have a negative impact on glioblastoma
keretsu, S.; Hana, T.; Lee, A.; Kedei, N.; Malik, N.; Kim, H.; Spurgeon, J.; Khayrullina, G.; Ruf, B.; Hara, A.; Coombs, M.; Watowich, M.; Watanabe, M.; Hari, A.; Ford, M. K. B.; Sahinalp, C.; Zaki, G.; Gilbert, M. R.; Cimino, P. J.; Prins, R.; Terabe, M.
10.1101/2022.07.17.499189 — immunology — Posted on 2025-01-07
4433 The Alzheimer's disease gene SORL1 regulates lysosome function in human microglia
Mishra, S.; Morshed, N.; Sidhu, S.; Kinoshita, C.; Stevens, B.; Jayadev, S.; Young, J. E.
10.1101/2024.06.25.600648 — neuroscience — Posted on 2025-01-07
4434 Integration of sensory and fear memories in the rat medial temporal lobe
Wong, F. S.; Thomas, A. B.; Killcross, S.; Laurent, V.; Westbrook, R. F.; Holmes, N. M.
10.1101/2024.07.31.605652 — neuroscience — Posted on 2025-01-07
4438 Amygdala GABA Neurons: Gatekeepers of Stress and Reproduction
Yu, J.; Farjami, S.; Nechyporenko, K.; Li, X. F.; Yaseen, H.; Lin, Y.; Ye, J.; Hollings, O.; O'Byrne, K. T.; Tsaneva-Atanasova, K.; Voliotis, M.
10.1101/2025.01.06.631361 — physiology — Posted on 2025-01-07
4439 FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis
Lange, M.; Wölk, M.; Doubravsky, C. E.; Hendricks, J. M.; Kato, S.; Otoki, Y.; Styler, B.; Nakagawa, K.; Fedorova, M.; Olzmann, J. A.
10.1101/2025.01.06.631537 — cell biology — Posted on 2025-01-06
4442 The miR156/SPL9 interaction mode regulates the anthocyanin accumulation in potato
Li, N.; Nie, H.; Wu, X.; Wang, P.; Ma, Y.; Yang, E.; Wu, J.; Zhang, Z.; Xie, R.; Wang, D.; Ma, Y.
10.1101/2025.01.06.631517 — molecular biology — Posted on 2025-01-06
4443 Methylglyoxal-induced glycation stress promotes aortic stiffening: Putative mechanistic roles of oxidative stress and cellular senescence
Singh, P.; Venkatasubramanian, R.; Mahoney, S.; Darrah, M.; Ludwig, K.; Zhang, A.; Kaneshiro, K.; Enriquez, L. N.; Wimer, L.; Shanmugam, M. M.; Morazan, E.; Trujillo, M.; Sarpong, R.; Galligan, J.; Seals, D.; Kapahi, P.; Clayton, Z. S.
10.1101/2025.01.06.631561 — molecular biology — Posted on 2025-01-06
4445 Mirror effect of genomic deletions and duplications on cognitive ability across the human cerebral cortex
Kumar, K.; Kazem, S.; Huguet, G.; Renne, T.; Engchuan, W.; Jean-Louis, M.; Kopal, J.; Saci, Z.; Thiruvahindrapuram, B.; MacDonald, J. R.; Mollon, J.; Schultz, L. M.; Knowles, E. E. M.; Porteous, D.; Davies, G.; Redmond, P.; Harris, S. E.; Cox, S. R.; Schumann, G.; Pausova, Z.; Greenwood, C. M. T.; Paus, T.; Scherer, S. W.; Almasy, L.; Sebat, J.; Glahn, D.; Dumas, G.; Jacquemont, S.
10.1101/2025.01.06.631492 — neuroscience — Posted on 2025-01-07
4446 Catalyzing computational biology research at an academic institute through an interest network
Zak, J.; Newman, I.; Montiel Garcia, D. J.; Parisi, D.; Joy, J.; Head, S. R.; Ducom, J.-C.; Natarajan, P.; Cui, H.; Ul-Hasan, S.
10.1101/2025.01.05.631403 — bioinformatics — Posted on 2025-01-06
4448 Development and Implementation of a Minority Health International Infectious Diseases Research Training Program
Sy, A.; Taylor, D.; Leaungwutiwong, P.; Phanupak, N.; Sirida, Y.; Leke, R.; Humphrey, P. S.; Tandon, R.; Kulkarni, M.; Madhivanan, P.; Kaholokula, J. K.; Nerurkar, V. R.
10.1101/2025.01.05.631114 — scientific communication and education — Posted on 2025-01-06
4450 Assessing Knowledge, Uptake and Factors associated with cervical cancer screening among women in selected communities of Wakiso District in Uganda: A population-based study
Bulamba, R. M.; Kyasanku, E.; Nalugoda, F.; Daama, A.; Nkale, J.; Miller, A. P.; Byansi, W.; Namutundu, J.; Kigozi, G.; Nalwoga, G. K.; Balwanaki, C.; Watya, S.; Ekström, A. M.; Mugamba, S.; Ndejjo, R.; Nakigozi, G.
10.1101/2025.01.05.631384 — scientific communication and education — Posted on 2025-01-06
4456 Heterochromatin de novo formation and maintenance in P. falciparum
Perez-Cantero, A.; Llora-Batlle, O.; Pelaez-Conde, I.; Martinez-Guardiola, C.; Cortes, A.
10.1101/2025.01.06.631576 — molecular biology — Posted on 2025-01-06
4457 A mechanistic understanding of the effect of Staphylococcus aureus VraS histidine kinase single point mutation on antibiotic resistance
Ali, L.; Karki, S.; Boorgula, G. D.; Mekakda, A.; Cagle-White, B.; Bhattarai, S.; Beaudoin, R.; Blakeney, A.; Singh, S.; Srivastava, S.; Abdelaziz, M. H.
10.1101/2025.01.06.631495 — microbiology — Posted on 2025-01-06
4458 Bacteria induce an amoeboid phase in coccolithophores that persists after bloom collapse
Zweifel, S. T.; Henshaw, R. J.; Mueller, O.; Keegstra, J. M.; Pioli, R.; Martinez-Perez, C.; Alcolombri, U.; Clerc, E.; Stocker, R.
10.1101/2025.01.06.631481 — microbiology — Posted on 2025-01-06
4461 Complex roles for proliferating cell nuclear antigen in human cytomegalovirus replication
Longmire, P.; Daigle, O.; Zeltzer, S.; Lee, M.; Svoboda, M.; Padilla-Rodriguez, M.; Bobak, C.; Bosco, G.; Goodrum, F.
10.1101/2025.01.06.631530 — microbiology — Posted on 2025-01-06
4463 An improved rapid and sensitive long amplicon method for nanopore-based RSV whole genome sequencing
Dong, X.; Edwards, S.; Deng, Y.-M.; Dapat, C.; Hirankitti, A.; Wordsworth, R.; Whitney, P.; Baird, R.; Freeman, K.; Daley, A. J.; Barr, I. G.
10.1101/2025.01.06.631406 — microbiology — Posted on 2025-01-06
4465 Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.
Dholakia, V.; Quantrill, J. L.; Richardson, S.; Pankaew, N.; Brown, M. D.; Yang, J.; Capelastegui, F.; Masonou, T.; Case, K.-M.; Aejian, J.; Staller, E.; Sheppard, C. M.; Brown, I. H.; Smith, C. M.; Iqbal, M.; Digard, P.; Barclay, W. S.; Pinto, R. M.; Peacock, T. P.; Goldhill, D. H.
10.1101/2025.01.06.631435 — microbiology — Posted on 2025-01-06
4466 Vertical transmission of core endophytes through the seeds
Sanz-Puente, I.; Redonde, S.; Torres-Cortes, G.; de Toro, M.; Fernandes, S.; Borner, A.; Lorenzo, O.; de la Cruz, F.; Robledo, M.
10.1101/2025.01.06.628327 — microbiology — Posted on 2025-01-06
4469 Food pairing independently associated with cardiometabolic traits beyond dietary patterns across western and eastern populations
Deng, Q.; Sun, Y.; Gu, M.; Fu, J.; Xu, F.; Jiao, Y.; Zhou, Y.; Ma, B.; Liu, L.; Wang, X.; Dong, Q.; Wu, T.; Zou, H.; Shi, J.; Wang, Y.; Sheng, Y.; Tang, L.; Sun, W.; Li, A.; Hu, S.; Zheng, J.-S.; He, Y.; Zhou, H.; Wu, W.; Kong, X.; Chen, L.
10.1101/2025.01.03.631167 — microbiology — Posted on 2025-01-06
4472 Butyrolactol A is a phospholipid flippase inhibitor that potentiates the bioactivity of caspofungin against resistant fungi
Chen, X.; Duan, H. D.; Hoy, M. J.; Koteva, K.; Spitzer, M.; Guitor, A. K.; Puumala, E.; Hu, G.; Yiu, B.; Bian, Z.; Chou, S.; Guo, A. B. Y.; Sun, S.; Robbins, N.; Cook, M. A.; Truant, R.; MacNeil, L. T.; Brown, E. D.; Kronstad, J. W.; Cowen, L. E.; Heitman, J.; Li, H.; Wright, G. D.
10.1101/2025.01.06.630955 — biochemistry — Posted on 2025-01-06
4476 Epigenetic landscape of the H3K27me3 mark in macrophages transformed by Theileria annulata
Sakura, T.; Tajeri, S.; Rchiad, Z.; Ansari, H. R.; Kaushik, A.; Mourier, T.; Pain, A.; Wassef, M.; Langsley, G.
10.1101/2025.01.06.631474 — microbiology — Posted on 2025-01-06
4477 Recent breeding experience improves egg ejection behaviour
Mari, L.; Hughes, A. E.; Troscianko, J.; Tomasek, O.; Albrecht, T.; Jelinek, V.; Sulc, M.
10.1101/2025.01.06.631447 — animal behavior and cognition — Posted on 2025-01-06
4478 More dominant baboons have less and lower quality sleep
Fele, M.; Christensen, C.; Bracken, A. M.; O'Riain, J.; Lurgi, M.; papadopoulou, M.; Fuerbauer, I.; King, A. J.
10.1101/2025.01.06.629345 — animal behavior and cognition — Posted on 2025-01-06
4479 Rhythms of Early Life: Gut Microbiota Rhythmicity and Circadian Maturation in infants
Muehlematter, C.; Nielsen, D. S.; Castro-Mejia, J.; Walser, J.-C.; Schoch, S.; Kurth, S.
10.1101/2025.01.06.631487 — developmental biology — Posted on 2025-01-06
4480 The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning
Zhang, Y.-F.; Dufour, J.-P.; Zatka-Haas, P.; Redgrave, P.; Black, M. J.; Lak, A.; Mann, E.; Cragg, S. J.; Abraham, W.; Reynolds, J. N.
10.1101/2025.01.06.631486 — neuroscience — Posted on 2025-01-06
4482 Accumbal acetylcholine signals associative salience
Zhang, Z.; Costa, K. M.; Zhuo, Y.; Li, G.; Li, Y.; Schoenbaum, G.
10.1101/2025.01.06.631529 — neuroscience — Posted on 2025-01-06
4483 Maturation of striatal dopamine supports the development of habitual behavior through adolescence
Petrie, D. J.; Parr, A. C.; Sydnor, V.; Ojha, A.; Foran, W.; Tervo-Clemmens, B.; Calabro, F.; Luna, B.
10.1101/2025.01.06.631527 — neuroscience — Posted on 2025-01-06
4487 Psilocybin induces sex- and context-specific recruitment of the stress axis
Cook, S. G.; Lee, S.; Ference, E.; Shi, Y.; Rojas-Carvajal, M.; Hen, R.; Bains, J. S.; Fuzesi, T.; Turi, G. F.
10.1101/2025.01.06.631556 — neuroscience — Posted on 2025-01-06
4489 Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin
Sia, C. M.; Ambrose, R. L.; Valcanis, M.; Andersson, P.; Ballard, S. A.; Howden, B. P.; Williamson, D. A.; Pearson, J. S.; Ingle, D. J.
10.1101/2024.07.30.605691 — microbiology — Posted on 2025-01-06
4490 High-throughput protein binder discovery by rapid in vivo selection
Styles, M. J.; Pixley, J. A.; Wei, T.; Basile, C.; Lu, S.; Dickinson, B. C.
10.1101/2025.01.06.631531 — synthetic biology — Posted on 2025-01-06
4491 Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila
Yadav, S.; Pan, X.; Li, S.; Martin, P. L.; Hoang, N.; Chen, K.; Karhadkar, A.; Malhotra, J.; Zuckerman, A. L.; Munan, S.; Klose, M. K.; Wang, L.; Cracan, V.; Parkhitko, A.
10.1101/2025.01.06.631511 — synthetic biology — Posted on 2025-01-06
4492 Engineering of CRISPR-Cas PAM recognition using deep learning of vast evolutionary data
Nayfach, S.; Bhatnagar, A.; Novichkov, A.; Estevam, G. O.; Kim, N.; Hill, E.; Ruffolo, J. A.; Silverstein, R. A.; Gallagher, J.; Kleinstiver, B. P.; Meeske, A. J.; Cameron, P.; Madani, A.
10.1101/2025.01.06.631536 — synthetic biology — Posted on 2025-01-06
4493 Longitudinal and multimodal auditing of tumor adaptation to CDK4/6 inhibitors in HR+ metastatic breast cancers
Creason, A. L.; Egger, J.; Watson, C.; Sivagnanam, S.; Chin, K.; MacPherson, K.; Lin, J.-R.; Chen, Y.-A.; Johnson, B. E.; Feiler, H. S.; Galipeau, D.; Navin, N. E.; Demir, E.; Chang, Y. H.; Corless, C. L.; Mitri, Z. I.; Thomas, G.; Sorger, P. K.; Adey, A. C.; Coussens, L. M.; Gray, J. W.; Mills, G. B.; Goecks, J.
10.1101/2023.09.27.557464 — cancer biology — Posted on 2025-01-06
4495 A glycerol oxidase from Norway spruce (Picea abies L. Karst.) expands biochemical and structural attributes of the GMC oxidoreductase superfamily
Paasela, T.; Schwenner, N.; Zhao, H.; Sun, M.; Haataja, T.; Karppi, J.; Vaattovaara, A.; Master, E.; Sandgren, M.; Karkonen, A.; Tenkanen, M.
10.1101/2025.01.06.631446 — biochemistry — Posted on 2025-01-06
4496 Parametrically guided design of beta barrels and transmembrane nanopores using deep learning
Kim, D. E.; Watson, J. L.; Juergens, D.; Majumder, S.; Sonigra, R.; Gerben, S. R.; Kang, A.; Bera, A. K.; Li, X.; Baker, D.
10.1101/2024.07.22.604663 — biochemistry — Posted on 2025-01-06
4497 Transcriptional Integration of Meiotic Prophase I Progression and Early Oocyte Differentiation
Abt, K. M.; Bartholomew, M. A.; Nixon, A. N.; Richman, H. E.; Gura, M. A.; Seymour, K. A.; Freiman, R. N.
10.1101/2025.01.06.631470 — genetics — Posted on 2025-01-06
4498 High genetic diversity and no detectable founder effects following a rapid range expansion of a long-distance migrant (Acrocephalus scirpaceus)
Bergman, N. M.; Lehikoinen, P.; Kluen, E.; Bensch, S.; Lo Cascio Saetre, C.; Eroukhmanoff, F.; Fossoy, F.; Prochazka, P.; Smith, W. J.; Stokke, B. G.; Primmer, C. R.; Thorogood, R.; Ronka, K.
10.1101/2025.01.06.631438 — evolutionary biology — Posted on 2025-01-06
4499 Recombination, truncation and horizontal transfer shape the diversity of cytoplasmic incompatibility patterns
Namias, A.; Martinez, J.; Boussou, I.; Terretaz, K.; Conner, W. R.; Justy, F.; Makoundou, P.; Perriat-Sanguinet, M.; Labbe, P.; Sicard, M.; Landmann, F.; Weill, M.
10.1101/2025.01.06.631454 — evolutionary biology — Posted on 2025-01-06
4501 Detection of airborne Coccidioides spores using lightweight portable air samplers affixed to uncrewed aircraft systems in California's Central Valley
Radosevich, M. T.; Dobson, S.; Weaver, A. K.; Lampman, P. T. A.; Kollath, D. R.; Couper, L.; Campbell, G.; Taylor, J.; Remais, J. V.; Kobziar, L.; Markwiese, J.; Head, J. R.
10.1101/2024.10.28.620741 — ecology — Posted on 2025-01-06
4502 Non-invasive characterization of oocyte deformability in micro-constrictions
Barbier, L.; Bulteau, R.; Rezaei, B.; Panier, T.; Labrune, E.; Verlhac, M.-H.; Vernerey, F.; Campillo, C.; Terret, M.-E.
10.1101/2025.01.06.631295 — developmental biology — Posted on 2025-01-06
4503 NNMT promotes tubular senescence and fibrosis in chronic kidney disease
Chanvillard, L.; Lantermans, H.; Wall, C.; Thevenet, J.; Butter, L.; Tauzin, L.; Claessen, N.; Christen, S.; Karaz, S.; Lassueur, S.; Izzo, G.; Sanchez Garcia, J. L.; Metairon, S.; Holzwarth, J.; Ferro, V.; Moco, S.; van Bommel, E.; van Baar, M.; Hesp, A.; van Raalte, D.; Roelofs, J.; Sanders, M.; Feige, J.; Sorrentino, V.; Tammaro, A.
10.1101/2025.01.06.631437 — cell biology — Posted on 2025-01-06
4504 DNA topological regulation by topoisomerase IIbeta-DNA-PK interaction is important for controlled hypoxia-inducible gene expression
Bunch, H.; Park, J.; Seu, M.-S.; Farmakes, J. K.; Lee, J.; Yoo, J.-S.; Lu, H.; Yoon, Y.-R.; Jeon, J.-H.; Schellenberg, M.; Kang, K.; Calderwood, S. K.; Davis, A. J.
10.1101/2025.01.06.631366 — molecular biology — Posted on 2025-01-06
4507 Rev-RRE activity modulates HIV-1 replication and latency reactivation: Implications for viral persistence and cure strategies
Dzhivhuho, G. A.; Jackson, P. E. H.; Honeycutt, E. S.; Mesquita, F. d. S.; Huang, J.; Hammarskjold, M.-L.; Rekosh, D.
10.1101/2025.01.06.631466 — microbiology — Posted on 2025-01-06
4508 Delineating JunB's Crucial Function in Mature Th17 Cells through Inducible Targeted Protein Degradation
Whitaker, C.; Sasaki, D.; Miyagi, M.; Hirota, M.; Tamai, M.; Wang, K.; Chien, H.-C.; Sarkar, S.; Toma, T.; Taira, N.; Ishikawa, H.
10.1101/2025.01.06.631425 — immunology — Posted on 2025-01-06
4512 Hierarchical whole-brain modeling of critical synchronization dynamics in human brains
Myrov, V.; Suleimanova, A.; Knapic, S.; Liu, W.; Partanen, P.; Vesterinen, M.; Palva, S.; Palva, J. M.
10.1101/2024.05.08.593146 — neuroscience — Posted on 2025-01-06
4513 Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling
Tetenborg, S.; Shihabeddin, E.; Kumar, E. O. A. M.; Sigulinsky, C.; Dedek, K.; Lin, Y.-P.; Echeverry, F.; Hoff, H.; Pereda, A.; Jones, B. W.; Ribelayga, C.; Ebnet, K.; Matsuura, K.; O'Brien, J.
10.1101/2024.11.26.625481 — neuroscience — Posted on 2025-01-06
4515 TERT prevents obesity-induced metabolic disorders by promoting adipose stem cell expansion and differentiation
Braud, L.; Bernabe, M.; Vernerey, J.; Miranda, A. M. A.; Dominguez, A.; Churikov, D.; Richaud, M.; McAllan, L.; Lachaud, C.; Gil, J.; Scott, W.; Geli, V.
10.1101/2025.01.06.631346 — physiology — Posted on 2025-01-06
4517 Melatonin attenuates kidney injury by alleviating lysosomal damage in diabetic kidney disease
Chen, J.; Zhang, S.; Ma, X.; Chen, A.; Wu, Y.; Wang, G.; Zhang, Q.; Xue, Y.; Jia, Y.; Zheng, Z.
10.1101/2025.01.06.631433 — pathology — Posted on 2025-01-06
4518 Corticotropin-releasing hormone in melanoma and non-melanoma skin cancer.
Mueller, M.; Melchers, S.; Mueller, I.; Utikal, J.; Krug, J.; Schmieder, A.
10.1101/2025.01.06.631434 — cancer biology — Posted on 2025-01-06
4519 Sequence-dependent co-condensation of Lsr2 with DNA elucidates the mechanism of genome compaction in Mycobacterium tuberculosis
Satheesh, T.; Singh, R. K.; Gaur, P.; Shahu, S.; Ramakrishnan, S.; Srivastava, M.; Neogi, S.; Choubey, S.; Ganji, M.
10.1101/2025.01.06.631453 — biophysics — Posted on 2025-01-06
4521 CHOPOFF: symbolic alignments enable fast and sensitive CRISPR off-target detection
Labun, K.; Rio, O.; Tjeldnes, H.; Swirski, M.; Komisarczuk, A. Z.; Haapaniemi, E. M.; Valen, E.
10.1101/2025.01.06.603201 — bioinformatics — Posted on 2025-01-06
4524 Biochemical and physiological characterization of Aedes aegypti midgut chymotrypsin
Ramirez, A. G.; Isoe, J.; Serafim, M. S. M.; Fong, D.; Le, M. A.; Nguyen, J. T.; Burata, O. E.; Lucero, R. M.; Rascon, A. A.
10.1101/2024.12.31.630969 — biochemistry — Posted on 2025-01-06
4526 Spatial-scERA: A method for reconstructing spatial single-cell enhancer activity in multicellular organisms
Alberti, B.; Vincent, S.; Stevant, I.; Lajoignie, D.; Tarayre, H.; Villoutreix, P.; Ghavi-Helm, Y.
10.1101/2024.10.02.616294 — genomics — Posted on 2025-01-06
4527 A Scalable Framework for Identifying Allelic Series from Summary Statistics
McCaw, Z. R.; Gao, J.; Dey, R.; Tucker, S.; Zhang, Y.; insitro Research Team, ; Gronsbell, J.; Li, X.; Fox, E.; O'Dushlaine, C.; Soare, T. W.
10.1101/2024.10.31.621375 — genetics — Posted on 2025-01-06
4529 Chiari II brain malformation is secondary to open spina bifida
Clark, M.; Edwards, T. J.; Savery, D.; Galea, G. L.; Samy, N.; Pauws, E.; Greene, N.; Copp, A.
10.1101/2025.01.06.631442 — developmental biology — Posted on 2025-01-06
4532 The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors
Ubah, O. C.; Lake, E. W.; Priyanka, S.; Shi, K.; Moeller, N. H.; Porter, A. J.; Aihara, H.; LeBeau, A. M.; Barelle, C. J.
10.1101/2024.07.30.605874 — pharmacology and toxicology — Posted on 2025-01-06
4535 Optimising CAR-T cell sensitivity by engineering matched extracellular sizes between CAR/antigen and CD2/CD58 adhesion complexes
Burton, J.; Siller-Farfan, J. A.; Andre, V.; Jenkins, E.; Barton, M. I.; Bustamante Eguiguren, S.; Cabezas-Caballero, J.; Davis, S.; Weikl, T. R.; van der Merwe, P. A.; Dushek, O.
10.1101/2025.01.06.631424 — immunology — Posted on 2025-01-06
4537 Control of tongue movements by the Purkinje cells of the cerebellum
Hage, P.; Fakharian, M. A.; Shoup, A. M.; Pi, J. S.; Sedaghat-Nejad, E.; Orozco, S. P.; Jang, I. K.; Looi, V.; Elseweifi, H.; Mohammadrezaei, N.; Vasserman, A.; Arginteanu, T.; Shadmehr, R.
10.1101/2024.07.25.604757 — neuroscience — Posted on 2025-01-06
4539 Decoding the Molecular Language of Proteins with Evola
Zhou, X.; Han, C.; Zhang, Y.; Su, J.; Zhuang, K.; Jiang, S.; Yuan, Z.; Zheng, W.; Dai, F.; Zhou, Y.; Tao, Y.; Wu, D.; Yuan, F.
10.1101/2025.01.05.630192 — bioinformatics — Posted on 2025-01-06
4543 Temporal and Notch identity determine layer targeting and synapse location of medulla neurons
Holguera, I.; Chen, Y.-C.; Chen, Y.-C. D.; Simon, F.; Gaffney, A. G.; Rodas, J. D.; Cordoba, S.; Desplan, C.
10.1101/2025.01.06.631439 — developmental biology — Posted on 2025-01-06
4544 Enhanced yield and subtype identity of hPSC-derived midbrain dopamine neuron by modulation of WNT and FGF18 signaling
Kim, T. W.; Piao, J.; Bocchi, V. D.; Koo, S. Y.; Choi, S. J.; Chaudhry, F.; Yang, D.; Cho, H. S.; Hergenreder, E.; Perera, L. R.; Joshi, S.; Mrad, Z. A.; Claros, N.; Donohue, S. A.; Frank, A. K.; Walsh, R.; Mosharov, E. V.; Betel, D.; Tabar, V.; Studer, L.
10.1101/2025.01.06.631400 — cell biology — Posted on 2025-01-06
4545 Human mitochondrial transfer modeling reveals biased delivery from mesenchymal-to-hematopoietic stem cells
Dupard, S. J.; Pinheiro, J. M.; Baudet, A.; Garcia Garcia, A.; Zacharaki, D.; Gil, D. H.; Prithiviraj, S.; Swaminathan, V.; Bourgine, P. E.
10.1101/2025.01.06.631461 — cell biology — Posted on 2025-01-06
4547 The Geometry and Dimensionality of Brain-wide Activity
Wang, Z.; Mai, W.; Chai, Y.; Qi, K.; Ren, H.; Shen, C.; Zhang, S.; Tan, G.; Hu, Y.; Wen, Q.
10.1101/2023.02.23.529673 — neuroscience — Posted on 2025-01-06
4550 Divergent endothelial mechanisms drive arteriovenous malformations in ALK1 and SMAD4 loss-of-function
Oppenheim, O.; Giese, W.; Park, H.; Baumann, E.; Ivanov, A.; Beule, D.; Eichmann, A.; Gerhardt, H.
10.1101/2025.01.03.631070 — developmental biology — Posted on 2025-01-06
4551 Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development
Wang, Q.; Li, H.; Mao, Y.; Garg, A.; Park, E. S.; Wu, Y.; Chow, A.; Peregrin, J.; Zhang, X.
10.1101/2024.10.20.619055 — developmental biology — Posted on 2025-01-06
4554 Bioenergetics of human spermatozoa in patients with testicular germ cell tumour
Simonik, O.; Bryndova, B.; Sur, V. P.; Ded, L.; Cockova, Z.; Benda, A.; Qasemi, M.; Pecina, P.; Pecinova, A.; Spevakova, D.; Hradec, T.; Skrobanek, P.; Ezrova, Z.; Kratka, Z.; Kren, R.; Jeseta, M.; Boublikova, L.; Zamecnik, L.; Buchler, T.; Neuzil, J.; Postlerova, P.; Komrskova, K.
10.1101/2024.05.24.595824 — cell biology — Posted on 2025-01-06
4556 Astrocytic RNA editing regulates the host immune response to alpha-synuclein
D'Sa, K.; Choi, M. L.; Wagen, A. Z.; Seto-Salvia, N.; Kopach, O.; Evans, J. R.; Rodrigues, M.; Lopez-Garcia, P.; Lachica, J.; Clarke, B. E.; Singh, J.; Ghareeb, A.; Bayne, J.; Grant-Peters, M.; Garcia-Ruiz, S.; Chen, Z.; Rodriques, S.; Athauda, D.; Gustavsson, E. K.; Gagliano Taliun, S. A.; Toomey, C.; Reynolds, R. H.; Young, G.; Strohbuecker, S.; Warner, T.; Rusakov, D. A.; Patani, R.; Bryant, C.; Klenerman, D. A.; Gandhi, S.; Ryten, M.
10.1101/2024.02.26.582055 — neuroscience — Posted on 2025-01-06
4557 Insulin resistance, cognition, and functional brain network topology in older adults with obesity
McIntyre, C. C.; Lyday, R. G.; Su, Y.; Nicklas, B. J.; Simpson, S. L.; Deep, G.; Macauley, S. L.; Hugenschmidt, C. E.
10.1101/2024.11.26.625552 — neuroscience — Posted on 2025-01-06
4558 MorphoCellSorter: An Andrews plot-based sorting approach to rank microglia according to their morphological features
Benkeder, S.; Dinh, S.-M.; Marchal, P.; De Gea, P.; Thoby-Brisson, M.; Hubert, V.; Hristovska, I.; Pitollat, G.; Combet, K.; Cardoit, L.; Pillot, B.; Leon, C.; Wiart, M.; Marthy, S.; Honnorat, J.; Pascual, O.; Comte, J.-C.
10.1101/2024.08.29.609024 — neuroscience — Posted on 2025-01-06
4559 Multi-modal image analysis for large scale cancer tissue studies within IMMUcan
Eling, N.; Dorier, J.; Rusakiewicz, S.; Devanand, P.; Daniel, M.; Windhager, J.; Fernandez, B. P.; Deglise, S.; Despland, L.; Benyagoub, A.; Loboda, S.; Sandkuijl, D.; Parsotam, N.; Hong, H. S.; Morfouace, M.; Guex, N.; Coukos, G.; Bodenmiller, B.; Tissot, S.; Schulz, D.
10.1101/2024.12.16.628597 — cancer biology — Posted on 2025-01-06
4560 MuSpAn: A Toolbox for Multiscale Spatial Analysis
Bull, J. A.; Moore, J. W.; Mulholland, E. J.; Leedham, S. J.; Byrne, H. M.
10.1101/2024.12.06.627195 — cell biology — Posted on 2025-01-06
4561 A New Approach to Monitoring Protein Transfer via Extracellular Vesicles
Chabronova, A.; Pigden, O.; Jenkins, R.; Jensen, A.; Clarke, E.; James, V.; Peffers, M. J.
10.1101/2024.12.16.628642 — molecular biology — Posted on 2025-01-06
4562 Does Precision Grip Research Extend to Unconstrained, Multidigit Grasping?
Lepori, F.; Hartmann, F. T.; Dehn, K. I.; Chessa, M.; Fleming, R. W.; Maiello, G.
10.1101/2024.12.20.627508 — neuroscience — Posted on 2025-01-06
4563 EPHA2-dependent Ephrin-B1 signaling supports self-renewal ability and recurrence of oral cancer
R, R. R.; U, S. K.; Shanmugam, G.; Datta, N.; Louis, J. M.; Jeyaram, R. D.; Datta, K. K.; Gowda, H.; Sarkar, M.; Nair, M. G.; Prabhu, J. S.; Shabeer, H.; P G, B.; A, T.; Jose, A.; Maliekal, T. T.
10.1101/2025.01.03.631197 — cancer biology — Posted on 2025-01-06
4567 Relevance of the synergy of surveillance and populational networks in understanding the Usutu virus outbreak within common blackbirds (Turdus merula) in Metropolitan France, 2018
Bouchez-Zacria, M.; Calenge, C.; Villers, A.; Lecollinet, S.; Gonzalez, G.; Quintard, B.; Leclerc, A.; Baurier, F.; Paty, M.-C.; Faure, E.; Eraud, C.; Decors, A.
10.1101/2024.07.22.604715 — ecology — Posted on 2025-01-06
4568 Delayed dichromatism in waterfowl as a convenient tool for assessing vital rates
Tableau, A.; Henderson, I.; Reeber, S.; Guillemain, M.; Maillard, J.-F.; Caizergues, A.
10.1101/2024.06.04.597326 — ecology — Posted on 2025-01-06
4575 From dimer to tetramer: the evolutionary trajectory of C4 photosynthetic-NADP-ME oligomeric state in Poaceae
Boehm, J. M.; Willms, S.; Ferrao, O.; Buitrago-Arango, M.; Huedig, M.; Poschmann, G.; Fazelnia, N.; Nagel-Steger, L.; Klinke, S.; Drakonaki, A.; Gatsogiannis, C.; Tronconi, M. A.; Alvarez, C. E.; Maurino, V. G.
10.1101/2025.01.05.631420 — evolutionary biology — Posted on 2025-01-06
4577 Regulation of transcription elongation anticipates alternative gene expression strategies across the cell cycle
Maya-Miles, D.; Garcia-Martinez, J.; Cases, I.; Pasion, R.; de la Cruz, J.; Perez-Ortin, J. E.; Munoz-Centeno, M. d. l. C.; Chavez, S.
10.1101/2025.01.05.631386 — molecular biology — Posted on 2025-01-05
4578 Vesicular glutamate release is necessary for neural tube formation
Goyal, R.; Castro, P. A.; Levin, J. B.; Shim, S.; Mizuno, G. O.; Tian, L.; Borodinsky, L. N.
10.1101/2025.01.05.631426 — neuroscience — Posted on 2025-01-06
4579 Key-cutting machine: A novel optimization framework for tailored protein and peptide design
Leyva, Y. C.; Torres, M. D. T.; Oliva, C. A.; de la Fuente-Nunez, C.; Brizuela, C. A.
10.1101/2025.01.05.631393 — bioengineering — Posted on 2025-01-05
4581 Changes in free-roaming dog population demographics and health associated with a catch-neuter-vaccinate-release program in Jamshedpur, India
Smith, L. M.; Kartal, T.; Rawat, S.; Chaudhari, A.; Kumar, A.; Pandey, R. K.; Quinnell, R. J.; Collins, L. M.
10.1101/2025.01.05.631379 — ecology — Posted on 2025-01-05
4586 VISTA-induced tumor suppression by a four amino acid intracellular motif
Zhao, Y.; Andoh, T.; Charles, F.; Reddy, P.; Paul, K.; Goar, H.; Durdana, I.; Golder, C.; Hardy, A.; Juntilla, M.; Yang, S.-R.; Lin, C.-Y.; Sagiv-Barfi, I.; Geller, B. S.; Moore, S.; Thakkar, D.; Boyd-Kirkup, J.; Peng, Y.; Ford, J. M.; Telli, M.; Zhang, S.; Kurian, A.; West, R. B.; Yue, T.; Lipchik, A. M.; Snyder, M.; Gruber, J. J.
10.1101/2025.01.05.631401 — cancer biology — Posted on 2025-01-05
4587 FAIRSCAPE: An Evolving AI-readiness Framework for Biomedical Research
Al Manir, S.; Levinson, M. A.; Niestroy, J.; Churas, C.; Parker, J. A.; Clark, T.
10.1101/2024.12.23.629818 — bioinformatics — Posted on 2025-01-05
4588 KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistance
Chatterjee, D.; Svoboda, R. A.; Huisman, D. H.; Drapkin, B. J.; Vieira, H. M.; Rao, C.; Askew, J. W.; Fisher, K. W.; Lewis, R. E.
10.1101/2024.02.23.581815 — cancer biology — Posted on 2025-01-05
4590 Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein
Shinkai, Y.; Ding, Y.; Matsui, T.; Devitt, G.; Akiyama, M.; Shen, T.-L.; Nishida, M.; Ida, T.; Akaike, T.; Mahajan, S.; Fukuto, J. M.; Shigeta, Y.; Kumagai, Y.
10.1101/2023.10.19.563042 — biochemistry — Posted on 2025-01-05
4592 Copy number variation contributes to parallel local adaptation in an invasive plant
Wilson, J. R.; Bieker, V. C.; van Boheemen, L.; Connallon, T.; Martin, M. D.; Battlay, P.; Hodgins, K. A.
10.1101/2024.07.03.601998 — evolutionary biology — Posted on 2025-01-05
4594 Caffeine induces age-dependent increases in brain complexity and criticality during sleep
Thölke, P.; Arcand-Lavigne, M.; Lajnef, T.; Frenette, S.; Carrier, J.; Jerbi, K.
10.1101/2024.05.27.596056 — neuroscience — Posted on 2025-01-05
4595 Binding items to contexts through conjunctive neural representations with the Method of Loci
Huang, J.; Manglik, A.; Dutra, N.; Tarder-Stoll, H.; Chamberlain, T. A.; Ajemian, R.; Zhang, Q.; Norman, K. A.; Baldassano, C.
10.1101/2024.12.19.629352 — neuroscience — Posted on 2025-01-05
4598 Engineered Living Glues for Autonomous Detection and On-Demand Treatment of Inflammatory Bowel Disease
Ge, C.; Jiang, S.; Dong, X.; Jiang, X.; Zhi, W.; Xiang, Y.; Yang, P.; Zhang, Q.; Chen, X.; Liu, Y.; Huang, S.; Liu, Y.; Lin, J.; An, B.; Huang, P.; Zhong, C.
10.1101/2025.01.04.630840 — synthetic biology — Posted on 2025-01-05
4599 An opioid efficacy switch for reversible optical control of peripheral analgesia
Posa, L.; Romano, G.; Ji, X.; Khan, S.; Paz, B.; Han, G. W.; Nazarova, A. L.; Zaidi, S. A.; Ranjbar, M.; Pleil, K. E.; Katritch, V.; Gati, C.; Trauner, D.; Levitz, J.
10.1101/2024.12.16.628735 — pharmacology and toxicology — Posted on 2025-01-05
4600 Kinase Suppressor of Ras 2 promotes self-renewal and clonogenicity of small-cell lung carcinoma
Huisman, D. H.; Chatterjee, D.; Svoboda, R. A.; Vieira, H. M.; Ireland, A. S.; Skupa, S.; Askew, J. W.; Frodyma, D. E.; Girard, L.; Fisher, K. W.; Kareta, M.; Minna, J.; Oliver, T. G.; Lewis, R. E.
10.1101/2022.02.11.480157 — cancer biology — Posted on 2025-01-05
4601 A novel pan class-I glucose transporter inhibitor DRB18 exhibits synergistic effects in vitro and in vivo with paclitaxel against human non-small cell lung cancer
Shriwas, P.; Bachmann, L.; Ward, R.; Adhicary, S.; Nielsen, C. M.; Li, Y.; Zhang, H.; Song, J.; Roberts, D.; Bergmeier, S.; Chen, X.
10.1101/2024.12.15.628558 — cancer biology — Posted on 2025-01-05
4603 Optimizing spinal cord injury in zebrafish larvae: effects of age on the injury response
Walker, W. J.; Underwood, K. L.; Garrett, P. I.; Lorbacher, K. B.; Linch, S. M.; Rynes, T. P.; Sloop, C.; Mruk, K.
10.1101/2023.05.18.541337 — developmental biology — Posted on 2025-01-05
4604 Populations of the Australian saltmarsh mosquito Aedes vigilax vary between panmixia and temporally stable local genetic structure
Schmidt, T. L.; Endersby-Harshman, N.; Mills, T.; Rane, R.; Pandey, G.; Hardy, C.; Court, L.; Webb, C.; Trewin, B.; Neilan, B.; Hoffmann, A. A.
10.1101/2025.01.05.631387 — evolutionary biology — Posted on 2025-01-05
4605 Caribbean octocoral communities: finding the forest for the trees?
Lasker, H. R.; Bramanti, L.; Edmunds, P. J.; Girard, J. F.; Pages, N.; Tonra, K.; Wells, C.; Guizien, K.
10.1101/2025.01.05.631368 — ecology — Posted on 2025-01-05
4606 Lack of ADAP1/Centaurin-α1 Ameliorates Cognitive Impairment and Neuropathological Hallmarks in a Mouse Model of Alzheimer's Disease
Szatmari, E. M.; Moran, C.; Cohen, S. J.; Bashtovyy, D.; Jacob, A. L.; Bunner, W.; Phipps, M.; Stackman, R. W.; Yasuda, R. L.
10.1101/2025.01.05.630617 — neuroscience — Posted on 2025-01-05
4610 Cycling Molecular Assemblies for Selective Cancer Cell Golgi Disruption
Tan, W.; Zhang, Q.; Liu, Z.; Qiu, K.; Divyanshu, M.; Gerton, T.; Copperman, N.; Xia, C.; Lin, C.; Lau, W.; Lee, M.; Ashton-Rickardt, I.; hong, P.; Dinulescu, D.; Hsieh, J.-T.; Loeb, D.; Drapkin, R.; Diao, J.; Lu, L.; Xu, B.
10.1101/2025.01.05.631374 — biochemistry — Posted on 2025-01-05
4611 C. elegans interprets dietary quality through context-dependent serotonergic modulation
Feng, L.; Marquina-Solis, J.; Yue, L.; Harnagel, A.; Greenfeld, Y.; Bargmann, C. I.
10.1101/2025.01.05.631367 — neuroscience — Posted on 2025-01-05
4615 NF-κB mediates transactivation of HNRNPD, resulting in PTEN destabilization and constitutive activation of the PI3K-AKT pathway in oral cancer cells
Kumar, V.; Mittal, A.; Kumar, A.; Lone, M. R.; Yadav, V.; Verma, P.; Pradhan, D.; Mishra, D.; Thakar, A.; Chauhan, S. S.
10.1101/2025.01.05.631360 — cancer biology — Posted on 2025-01-05
4616 Dissection of ergosterol metabolism reveals a pathway optimized for membrane phase separation
Juarez-Contreras, I.; Lopes, L. J. S.; Holt, J.; Yu-Liao, L.; O'Shea, K.; Ruiz-Ruiz, J.; Sodt, A.; Budin, I.
10.1101/2025.01.05.631358 — biophysics — Posted on 2025-01-05
4619 Misspelled-word reading modulates late cortical dynamics
You, J.; Saranpaa, A.; Lindh-Knuutila, T.; Vliet, M. v.; Salmelin, R.
10.1101/2025.01.05.631357 — neuroscience — Posted on 2025-01-05
4620 PEARL: Protein Eluting Alginate with Recombinant Lactobacilli
Tadimarri, V. S.; Blanch-Asensio, M.; Deshpande, K.; Baumann, J.; Baumann, C.; Mueller, R.; Trujillo, S.; Sankaran, S.
10.1101/2024.09.12.612671 — bioengineering — Posted on 2025-01-05
4621 Oligosaccharyltransferase is involved in targeting to ER-associated degradation
Shenkman, M.; Ogen-Shtern, N.; Patel, C.; Groisman, B.; Pasmanik-Chor, M.; Schermann, S. M.; Korner, R.; Lederkremer, G. Z.
10.1101/2024.05.12.593735 — cell biology — Posted on 2025-01-05
4622 Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation.
Hadebe, S.; Savulescu, A. F.; Khumalo, J.; Jones, K.; Mangali, S.; Mthembu, N.; Musaigwa, F.; Maepa, W.; Ndlovu, H.; Ngomti, A.; Scibiorek, M.; Okendo, J.; Brombacher, F.
10.1101/2023.08.02.551636 — immunology — Posted on 2025-01-05
4625 Leaf size determines damage- and herbivore-induced volatile emissions in maize
Waterman, J. M.; Cofer, T. M.; von Laue, O. M.; Mateo, P.; Wang, L.; Erb, M.
10.1101/2024.11.14.623649 — plant biology — Posted on 2025-01-05
4626 Progressive chromosome shape changes quantified during cell divisions
Kakui, Y.; Kusano, Y.; Clarence, T.; Lopez, M.; Hirota, T.; Khatri, B. S.; Uhlmann, F.
10.1101/2024.11.19.623756 — biophysics — Posted on 2025-01-05
4627 An arginine switch drives the stepwise activation of β-arrestin
Ji, J. S.; Yun, Y.; Stepniewski, T.; Yoon, H.-J.; Min, K.; Park, J. Y.; Chung, C.; Chung, K. Y.; Selent, J.; Lee, H. H.
10.1101/2025.01.05.631353 — biochemistry — Posted on 2025-01-05
4629 An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Marques, E.; Burr, S. P.; Casey, A. M.; Stopforth, R. J.; Yu, C. S.; Turner, K.; Wolf, D. M.; Dilucca, M.; Tyrrell, V. J.; Kramer, R.; Kanse, Y. M.; Powell, C. A.; Stewart, J. B.; Murphy, M. P.; Minczuk, M.; O'Donnell, V.; Bryant, C. E.; Chinnery, P. F.; Kaser, A.; von Kriegsheim, A.; Ryan, D. G.
10.1101/2025.01.05.631298 — immunology — Posted on 2025-01-05
4630 Nutrient availability dictates cancer metabolism-based therapeutic responses of non-oncology drugs
Pyun, W. Y.; Park, J.-H.; Roh, J. W.; Kim, J.; Paik, J. E.; Cho, S. C.; Park, S. Y.; Jeong, H.-S.; Namkung, W.; Nam, J. H.; Park, H. W.
10.1101/2025.01.05.631340 — cancer biology — Posted on 2025-01-05
4631 Tumour suppressor WT1 and its interacting protein RNA helicase DDX5 regulate the microRNA let7/Igf1r axis in the kidney mesenchyme
Dey, S.; Slight, J.; Aitken, S.; Joseph, I.; Bhore, U.; vonkriegsheim, A.; Petrovich, G.; Charlton, J.; Stancheva, V.; Mohapatra, D.; Essafi, A.; Pritchard Jones, K.; Hastie, N.; Bharathavikru, R. S.
10.1101/2025.01.05.631347 — cancer biology — Posted on 2025-01-05
4632 Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism
Wu, W.; Yu, M.; Li, Q.; Zhao, Y.; Zhang, L.; Sun, Y.; Wang, Z.; Gong, Y.; Wang, W.; Liu, C.; Zhang, J.; Tang, Y.; Xu, X.; Guo, X.; Zhan, J.; Zhang, H.
10.1101/2024.08.01.606147 — cancer biology — Posted on 2025-01-05
4637 IFNγ activates an immune-like regulatory network in the cardiac vascular endothelium
Arthur, T. D.; Joshua, I. N.; Nguyen, J. P.; D'Antonio-Chronowska, A.; D'Antonio, M.; Frazer, K. A.
10.1101/2024.05.03.592380 — bioinformatics — Posted on 2025-01-05
4640 RNA-triggered CRISPR-Cas12a2 Preferentially and Cooperatively Cleaves Collateral DNA
Hallmark, T.; Kunwar, S.; Manna, S.; Keiser, D.; Naegle, B.; Thomas, A.; Beisel, C. L.; Jackson, R. N.
10.1101/2025.01.05.631166 — biochemistry — Posted on 2025-01-05
4644 Checkpoint receptors in circulating γδ T cells can discern the outcome of cancer immunotherapy
Catafal Tardos, E.; Dachicourt, L.; Baglioni, M. V.; Fares da Silva, M. G. F.; Secci, D.; Donia, M.; Kverneland, A.; Svane, I. M.; Bekiaris, V.
10.1101/2025.01.05.631352 — immunology — Posted on 2025-01-05
4647 Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease
Spencer, P. N.; Wang, J.; Smith, E. P.; Spiga, L.; Simmons, A. J.; Kim, T.; Kim, W.; Brown, M. E.; Yang, Y.; Kaur, H.; Xu, Y.; Kang, S. W.; Helou, M. D.; Lee, M. A.; Zheng, L.; Arceneaux, D.; Tasneem, N.; Mueller, K. D.; Kuddar, O. S.; Harned, M. H.; Ro, J.; Li, J.; Banerjee, A.; Markham, N. O.; Wilson, K. T.; Coburn, L. A.; Goettel, J. A.; Liu, Q.; Washington, M. K.; Valdivia, R. H.; Zhu, W.; Lau, K. S.
10.1101/2025.01.04.630951 — cell biology — Posted on 2025-01-04
4652 Humidity-driven ABA depletion determines plant-pathogen competition for leaf water
Yasuda, S.; Shinozawa, A.; Hirase, T.; Weng, Y.; Ishizaki, H.; Suzuki, R.; Ueda, S.; Sk, R.; Yotsui, I.; Toyota, M.; Okamoto, M.; Saijo, Y.
10.1101/2025.01.04.631318 — plant biology — Posted on 2025-01-04
4657 Studies of all-trans retinoic acid transport in myopigenesis
Chatterjee, S.; Roy, A.; Yu, J.; Read, A. T.; Bentley-Ford, M. R.; Pardue, M. T.; Kane, M. A.; Finn, M. G.; Ethier, C. R.
10.1101/2025.01.04.631331 — biochemistry — Posted on 2025-01-04
4658 High-efficiency Kemp eliminases by complete computational design
Listov, D.; Vos, E.; Hoffka, G.; Hoch, S. Y.; Berg, A.; Hamer-Rogotner, S.; Dym, O.; Kamerlin, S. C. L.; Fleishman, S. J.
10.1101/2025.01.04.631280 — biochemistry — Posted on 2025-01-04
4661 Non-Contrast microCT Analysis of Obese Adipose in Response to Cold-Exposure Reveals Sex-Specific Alterations
Eades, A. E.; Payne, M. M.; Clark, Z.; Evans, L.; Walsh, R. M.; Bye, B. B.; Rekowski, M.; Morris, E. M. M.; Bossmann, S. H.; VanSaun, M.
10.1101/2025.01.04.631266 — cell biology — Posted on 2025-01-04
4663 A two-step mechanism for RIG-I activation by influenza virus mini viral RNAs
Pitre, E.; Bisht, K.; Remick, K.; Ghorbani, A.; yewdell, j. J. W.; Elshina, E.; te Velthuis, A. J. W.
10.1101/2025.01.04.630666 — microbiology — Posted on 2025-01-04
4670 Pea-Saving Partners: Bacillus and Pseudomonas combat downy mildew in pea crops
Okechukwu, E. C.; Jimenez-Quiros, C.; Baysal, O.; Kocamaz, S.; Arikan, B.; Webb, A.; Wood, T.; Arora, S.; Domoney, C.; Studholme, D. J.; Tor, M.
10.1101/2025.01.04.631291 — plant biology — Posted on 2025-01-04
4671 Next-Generation Mapping of the ACINUS-Mediated Alternative Splicing Machinery and Its Regulation by O-glycosylation in Arabidopsis
Shrestha, R.; Reyes, A. V.; Carey, S.; Karunadasa, S. S.; Zhai, W.; Byun, D.; Lin, W.-D.; Li, J.; Alerte, K.; Cui, H.; Wang, Z.-Y.; Xu, S.-L.
10.1101/2025.01.04.631329 — plant biology — Posted on 2025-01-04
4673 ModiDeC: a multi-RNA modification classifier for direct nanopore sequencing
Alagna, N.; Muendnich, S.; Miedema, J.; Pastore, S.; Lehmann, L.; Wierczeiko, A.; Friedrich, J.; Walz, L.; Joerg, M.; Butto, T.; Friedland, K.; Helm, M.; Gerber, S.
10.1101/2025.01.04.631307 — bioinformatics — Posted on 2025-01-04
4674 LCORL and STC2 variants increase body size and growth rate in cattle and other animals
Bai, F.; Cai, Y.; Qiu, M.; Liang, C.; Pan, L.; Liu, Y.; Feng, Y.; Cao, X.; Yang, Q.; Ren, G.; Jiao, S.; Gao, S.; Lu, M.; Wang, X.; Heller, R.; Lenstra, J. A.; Jiang, Y.
10.1101/2025.01.01.630985 — genetics — Posted on 2025-01-04
4675 Natural variation modifies centromere proximal meiotic crossover frequency and segregation distortion in Arabidopsis thaliana
Gorringe, N.; Topp, S.; Burns, R.; Yamaguchi, S.; Rabanal, F. A.; Fernandes, J. B.; Weigel, D.; Kakutani, T.; Naish, M.; Henderson, I. R.
10.1101/2025.01.04.631303 — genetics — Posted on 2025-01-04
4676 Multi-Omics Atlas-Assisted Discovery of Transcription Factors for Selective T Cell State Programming
Chung, H. K.; Liu, C.; Jambor, A. N.; Riesenberg, B. P.; Sun, M.; Casillas, E.; Chen, T.; Chick, B.; Wang, Z. A.; Wang, J.; Mcdonald, B.; Wang, J.; He, P.; Yang, Q.; Varanasi, S. K.; Mann, T.; Chen, D.; Hoffmann, F.; Tripple, V.; Hang, Y.; Ho, J.; Cho, U. H.; Williams, A.; Wang, Y.; Hargreaves, D.; Thaxton, J. E.; Kaech, S. M.; Wang, W.
10.1101/2023.01.03.522354 — immunology — Posted on 2025-01-04
4677 Spatial Expression of Long Non-Coding RNAs in Human Brains of Alzheimer's Disease
Ng, B.; Avey, D. R.; Lopes, K. d. P.; Fujita, M.; Vialle, R. A.; Vyas, H.; Kearns, N. A.; Tasaki, S.; Iatrou, A.; Tissera, S. D.; Chang, T.-H.; Xu, J.; Yu, C.; Sultan, F.; Menon, V.; Gaiteri, C.; De Jager, P. L.; Bennett, D. A.; Wang, Y.
10.1101/2024.10.27.620550 — neuroscience — Posted on 2025-01-04
4678 Multisensory gamma stimulation enhances adult neurogenesis and improvescognitive function in male mice with Down Syndrome
Islam, M. R.; Jackson, B.; Naomi, M. T.; Schatz, B.; Tan, N.; Murdock, M.; Park, D. S.; Amorim, D. R.; Jiang, F.; Pineda, S. S.; Adaikkan, C.; Fernandez, V.; Geigenmuller, U.; Firenze, R. M.; Kellis, M.; Boyden, E. S.; Tsai, L.-H.
10.1101/2024.10.03.616486 — neuroscience — Posted on 2025-01-04
4681 Molecular signatures of heat tolerance and sensitivity in the alpine plant Wahlenbergia ceracea during moderate warming
Notarnicola, R. F.; Arnold, P. A.; Feng, Z.-P.; Hamilton, J.; Jones, A.; Loke, S.; Schwessinger, B.; Nicotra, A. B.; Ganguly, D. R.
10.1101/2023.09.27.559694 — plant biology — Posted on 2025-01-04
4682 DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
Tannus Ruckert, M.; McKinnon Walsh, R.; Bye, B. A.; Eades, A. E.; Yan, W.; Bednar, F.; Shi, J.; Lyssiotis, C. A.; VanSaun, M.; Silva Silveira, V.
10.1101/2024.12.20.629199 — cancer biology — Posted on 2025-01-04
4685 Rapid establishment of species barriers in plants compared to animals
Monnet, F.; Postel, Z.; Touzet, P.; Fraisse, C.; Van de Peer, Y.; Vekemans, X.; Roux, C.
10.1101/2023.10.16.562535 — evolutionary biology — Posted on 2025-01-04
4688 Stimulus novelty uncovers coding diversity in survey of visual cortex
Garrett, M.; Groblewski, P.; Piet, A.; Ollerenshaw, D.; Najafi, F.; Yavorska, I.; Amster, A.; Bennett, C.; Buice, M.; Caldejon, S.; Casal, L.; D'Orazi, F.; Daniel, S.; de Vries, S. E.; Kapner, D.; Kiggins, J.; Lecoq, J.; Ledochowitsch, P.; Manavi, S.; Mei, N.; Morrison, C. B.; Naylor, S.; Orlova, N.; Perkins, J.; Ponvert, N.; Roll, C.; Seid, S.; Williams, D.; Williford, A.; Ahmed, R.; Amine, D.; Billeh, Y.; Bowman, C.; Cain, N.; Cho, A.; Dawe, T.; Departee, M.; Desoto, M.; Feng, D.; Gale, S.; Gelfand, E.; Gradis, N.; Grasso, C.; Hancock, N.; Hu, B.; Hytnen, R.; Jia, X.; Johnson, T.; Kato, I.;
10.1101/2023.02.14.528085 — neuroscience — Posted on 2025-01-04
4689 Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling
Tetenborg, S.; Shihabeddin, E.; Kumar, E. O. A. M.; Sigulinsky, C.; Dedek, K.; Lin, Y.-P.; Echeverry, F.; Hoff, H.; Pereda, A.; Jones, B. W.; Ribelayga, C.; Ebnet, K.; Matsuura, K.; O'Brien, J.
10.1101/2024.11.26.625481 — neuroscience — Posted on 2025-01-04
4691 Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis
Potts, M. A.; Mizutani, S.; Deng, Y.; Vaidyanathan, S.; Ting, K.; Giner, G.; Shruti, S.; Liao, Y.; Diepstraten, S.; Kueh, A. J.; Pal, M.; Healey, G.; Tai, L.; Wang, Z.; Koenig, C.; Kaloni, D.; Whelan, L.; Milevskiy, M.; Pomilio, G.; Wei, A.; Visvader, J. E.; Papenfuss, A. T.; Wilcox, S.; Jeyasekharan, A.; Shi, W.; Lelliott, E.; Kelly, G. L.; Brown, K.; Strasser, A.; Herold, M. J.
10.1101/2022.02.16.480657 — cancer biology — Posted on 2025-01-04
4694 Prediction of peptide structural conformations with AlphaFold2
Ille, A. M.; Markosian, C.; Burley, S. K.; Pasqualini, R.; Arap, W.
10.1101/2024.12.03.626727 — bioinformatics — Posted on 2025-01-04
4695 AI-enabled Alkaline-resistant Evolution of Protein to Apply in Mass Production
Kang, L.; Wu, B.; Zhou, B.; Tan, P.; Kang, Y.; Yan, Y.; Zong, Y.; Li, S.; Liu, Z.; Hong, L.
10.1101/2024.09.04.611192 — bioinformatics — Posted on 2025-01-04
4697 Leveraging Crosslinker Diffusion to Template Stiffness Gradients in Alginate Hydrogels
Ostrowski, Z.; Price, T.; Zhang, J.; Foroozandehfar, A.; Namanda, F. R.; Kaufmann, T.; Judka, N.; Gardner, T.; Thatcher, M.; Miller, E.; Mesyk, L.; Koep, A.; Melvin, A. T.; Ren, J.; Schneider, I. C.
10.1101/2024.06.26.599742 — bioengineering — Posted on 2025-01-04
4698 Scale invariance of mechanical properties in the developing mammalian retina
Shelton, E. R.; Frischmann, M.; Brinkop, A. T.; James, R. M.; Serwane, F.
10.1101/2024.10.21.619491 — bioengineering — Posted on 2025-01-04
4699 Structural evolution of the estrogen receptor regulatory domain
McDougal, D. P.; Pederick, J. L.; Shearwin-Whyatt, L. M.; Grutzner, F.; Bruning, J. B.
10.1101/2024.12.18.629305 — biochemistry — Posted on 2025-01-04
4700 High-Resolution Genome-Wide Maps Reveal Widespread Presence of Torsional Insulation
Hall, P. M.; Mayse, L. A.; Bai, L.; Smolka, M. B.; Pugh, B. F.; Wang, M. D.
10.1101/2024.10.11.617876 — genomics — Posted on 2025-01-04
4701 40S ribosomal subunits scan mRNA for the start codon by one-dimensional diffusion
Wakabayashi, H.; Zhu, M.; Grayhack, E. J.; Mathews, D. H.; Ermolenko, D. N.
10.1101/2024.12.30.630811 — genetics — Posted on 2025-01-04
4703 Resource Quality Differentially Impacts Daphnia Interactions with Two Parasites
Fearon, M. L.; Sanchez, K. F.; Sun, S.-J.; Calhoun, S. K.; Monell, K. J.; Ravichandran, V.; Duffy, M. A.
10.1101/2024.07.31.605800 — ecology — Posted on 2025-01-04
4704 Single cell RNA sequencing reveals a shift in cell function and maturation of endogenous and infiltrating cell types in response to acute intervertebral disc injury
Clayton, S. W.; Sebastian, A.; Wilson, S. P.; Hum, N. R.; Walk, R. E.; Easson, G. W.; Vaidya, R. S.; Broz, K. S.; Loots, G. G.; Tang, S. Y.
10.1101/2024.08.10.607363 — cell biology — Posted on 2025-01-04
4705 Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3
Hennes, E.; Lucas, B.; Scholes, N. S.; Cheng, X.-f.; Scott, D. C.; Bischoff, M.; Reich, K.; Gasper, R.; Lucas, M.; Xu, T. T.; Pulvermacher, L.-M.; Doetsch, L.; Imrichova, H.; Brause, A.; Naredla, K. R.; Sievers, S.; Kumar, K.; Janning, P.; Gersch, M.; Murray, P. J.; Schulmann, B. A.; Winter, G. E.; Ziegler, S.; Waldmann, H.
10.1101/2024.07.10.602857 — cell biology — Posted on 2025-01-04
4708 Starvation of the bacteria Vibrio atlanticus promotes lightning group-attacks on the dinoflagellate Alexandrium pacificum
Rolland, J. L.; Masseret, E.; Laabir, M.; TETREAU, G.; gourbal, b.; Thebault, A.; Abadie, E.; Rodrigues-Stien, A.; Veckerle, C.; servanne.meunier, e.; Destoumieux-Garzon, D.; Lagorce, A.; lami, r.
10.1101/2024.12.18.629110 — microbiology — Posted on 2025-01-04
4715 ALDH1 subtype-specific inhibitor targets key cancerous epithelial cell populations in aggressive subtypes of breast cancer
PEREZ, M.; Farres, J.; Rebollido-Rios, R.; Pequerul, R.; Constantinescu, A.; Janji, B.; Kumar, A.; Pares-Casampera, X.; Palacios, O.; Colignon, D.; Berrou, A.; Fournet, G.; Martin, G.; Ceylan, I.
10.1101/2024.10.18.619128 — cancer biology — Posted on 2025-01-04
4718 Nanomotif: Leveraging DNA Methylation Motifs for Genome Recovery and Host Association of Plasmids in Metagenomes from Complex Microbial Communities
Heidelbach, S.; Dall, S. M.; Boejer, J. S.; Nissen, J.; van der Maas, L. N. L.; Sereika, M.; Kirkegaard, R.; Kousgaard, S. J.; Thorlacius-Ussing, O.; Jensen, S. I.; Hose, K.; Nielsen, T. D.; Albertsen, M.
10.1101/2024.04.29.591623 — bioinformatics — Posted on 2025-01-04
4719 Mapping interactions within the NMD decapping complex reveals how Upf1 recruits Dcp2 onto mRNA targets
RUIZ GUTIERREZ, N.; DUPAS, J.; AUQUIER, E.; BARBARIN-BOCAHU, I.; GAUDON-PLESSE, C.; Saveanu, C.; GRAILLE, M.; LE HIR, H.
10.1101/2024.12.18.629111 — biochemistry — Posted on 2025-01-04
4721 Genomic Diversity and Antimicrobial Resistance of Vibrio cholerae Isolates from Africa: A PulseNet Africa Initiative Using Nanopore Sequencing to Enhance Genomic Surveillance
Foster-Nyarko, E.; Able-Thomas, S.; Adade, N. E.; Adade, R.; Anne, J. C. B.; Antwi, L.; Bah, Y.; Boateng, G.; Carleton, H.; Chaima, D.; Chilengi, R.; Coulibaly, K. J.; Derra, F. A.; Didon, D.; Dimuna, C.; Dosso, M.; Drammeh, M. M.; Ferjani, S.; Holt, K. E.; Jatta, R.; Kalule, J. B.; Kanteh, A.; Kette, H. F.; Khan, D.; Kouadio, N. K. N.; Lee, C.; Mantina, H.; Mulenga, G.; Mwaba, J.; Nyang, F.; Owusu-Okyere, G.; Rowland, J.; Seck, A.; Sesay, A. K.; Smith, A.; Smith, P.; Soma, D.; Tau, N.; Tchuint, P. L. S.; Tientcheu, P.-E. M.; Sokoni, C.; Vakou, S. N.; Vubil, D.; PulseNet Africa,
10.1101/2024.12.17.628868 — genomics — Posted on 2025-01-04
4723 Mettl15-Mettl17 modulates the transition from early to late pre-mitoribosome
Zgadzay, Y.; Mirabello, C.; Wanes, G.; Panek, T.; Chauhan, P.; Nystedt, B.; Zikova, A.; Gahura, O.; Amunts, A.
10.1101/2024.12.18.629302 — molecular biology — Posted on 2025-01-04
4724 Identifying genomic surveillance gaps in Africa for the global public health response to West Nile Virus
Moir, M.; Sitharam, N.; Hofstra, M.; Dor, G.; Mwanyika, G.; Ramphal, Y.; Reichmuth, M. L.; San, J. E.; Gifford, R.; Wilkinson, E.; Tshiabula, D.; Preiser, W.; Konou, A. A.; Bitew, M.; Onoja, B. A.; Paganotti, G. M.; Abera, A.; Maror, J. A.; Kayiwa, J.; Abuelmaali, S.; Lusamaki, E. K.; Venter, M.; Burt, F.; Baxter, C.; Lessels, R.; de Oliveira, T.; Tegally, H.
10.1101/2024.12.18.629123 — molecular biology — Posted on 2025-01-04
4725 Chemosynthesis enhances carbon fixation in an active microbialite ecosystem
Ricci, F.; Leung, P. M.; Hutchinson, T.; Nguyen-Dinh, T.; Hood, A. v. S.; Salazar, V. W.; Eate, V.; Wong, W. W.; Cook, P. L. M.; Greeening, C.; McClelland, H.
10.1101/2024.12.18.629060 — microbiology — Posted on 2025-01-04
4726 Insights into the spool-like architecture and infectionstrategy of the archaeal virus SEV1
Zhang, H.; Wang, H.; Li, Y.; Fan, Y.; Zhang, Z.; Chen, H.; Song, K.; Huang, L.; Zhu, P.
10.1101/2024.12.18.629138 — microbiology — Posted on 2025-01-04
4727 Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease.
Chaichana, P.; Satapoomin, N.; Kullapanich, C.; Chuenklin, S.; Mohammad, A.; Inthawong, M.; Ball, E.; Burke, T. P.; Sunyakumthorn, P.; Salje, J.
10.1101/2024.12.18.629091 — microbiology — Posted on 2025-01-04
4729 HIV-1 Vpr alters cellular transcription by targeting the PAF1 complex
Biguet, M.; Marno, K.; Oliveira, N.; Gibbons, J. M.; Pade, C.; Jones, C. E.; McKnight, A.
10.1101/2024.12.18.629146 — microbiology — Posted on 2025-01-04
4730 Global expression profile of Enterohemorrhagic Escherichia coli O157:H7 in phagosome of murine macrophages
Riviere, N. A.; Jiang, L.; Wu, X.; Casabonne, M. C.; Guo, L.; Smith, L. Y.; Marques Da Silva, W.; Cataldi, A. A.; Xing, K.; Bei, J.; Larzabal, M.
10.1101/2024.12.18.629128 — microbiology — Posted on 2025-01-04
4731 Exploring new Bacteroidota strains: Functional Diversity and Probiotic Characteristics
Ladewig, L.; Tufail, M. A.; Kinfu, B. M.; Fokt, H.; Baines, J. F.; Schmitz, R. A.
10.1101/2024.12.18.628894 — microbiology — Posted on 2025-01-04
4732 Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely injured lungs
Baker, J. M.; Flott, T. L.; McLellan, L. A.; Bustos, I. G.; Guerrero, J. L.; Mendez, L. M.; Petouhoff, A. M.; Ranjan, P.; Metcalf, J. D.; McDonald, R. A.; Falkowski, N. R.; He, Y.; Cala, M. P.; Huffnagle, G. B.; Sjoding, M. W.; Reyes, L. F.; Stringer, K. A.; Dickson, R. P.
10.1101/2024.12.18.629020 — microbiology — Posted on 2025-01-04
4735 EXPLORING SOCIAL COGNITION DECLINE ACROSS ALZHEIMER'S DISEASE SEVERITY: INSIGHTS FROM A COMPARATIVE ANALYSIS
Martins, G. C.; Duarte Vieira, V. L.; Leme de Arruda, A. M.; Miluzzi Pinetti, F.; Maruta Siqueira, D.; Salvador Rocco, I.; de Oliveira Bertolucci, P. H.; Tufik,, S.; Berlim de Mello, C.
10.1101/2024.12.17.629002 — neuroscience — Posted on 2025-01-04
4737 Neural Speech-Tracking During Selective Attention: A spatially realistic audiovisual study
Har-shai Yahav, P.; Rabinovitch, E.; Korisky, A.; Vaknin Harel, R.; Zion Golumbic, E.
10.1101/2023.12.27.573349 — neuroscience — Posted on 2025-01-04
4738 What makes human cortical pyramidal neurons functionally complex
Aizenbud, I.; Yoeli, D.; Beniaguev, D.; de Kock, C. P.; London, M.; Segev, I.
10.1101/2024.12.17.628883 — neuroscience — Posted on 2025-01-04
4739 TCR clonality and TCR clonal expansion in the in situ microenvironment of non-small cell lung cancer
Yu, H.; Magoulopoulou, A.; Amini, R.-m.; Chatzinikolaou, M. P.; Horie, M.; Lindberg, A.; Mezheyeuski, A.; Backman, M.; Metousis, A.; Brunstrom, H.; Zuniga, M. M.; Botling, J.; Mattsson, J. S. M.; Karre, K.; Leandersson, K.; Nilsson, M.; Strell, C.; Micke, P.
10.1101/2024.12.17.628857 — cancer biology — Posted on 2025-01-04
4740 High-pressure Golgi neuronal staining for X-ray whole-brain imaging
Tang, Q.; Cai, X.; Liu, Y.; Zhang, Y.; Yan, X.; Zhou, F.; Zhang, J.; Li, Q.; Li, K.; Deng, B.; Wang, L.; Li, J.; Zhu, Y.; Fan, C.; Hu, J.
10.1101/2025.01.04.631279 — biophysics — Posted on 2025-01-04
4744 Wolbachia and its pWCP plasmid show differential dynamics during the development of Culex mosquitoes
Brunner, A. S.; Gauliard, C.; Tutagata, J.; Bordenstein, S.; Bordenstein, S.; Trouche, B.; Reveillaud, J.
10.1101/2025.01.03.631243 — microbiology — Posted on 2025-01-04
4746 Zero-phase-delay connectivity increases the reliability, concordance with structure, and prognostic ability of functional connectivity metrics
Mehra, C.; Beyh, A.; Laiou, P.; Garces, P.; Murphy, D.; Loth, E.; Dell' Acqua, F.; Ewen, J.; Richardson, M.; O'Muircheartaigh, J.
10.1101/2025.01.04.631256 — neuroscience — Posted on 2025-01-04
4747 Altered brain-ventricle coupling modes over Alzheimer's disease progression detected with fMRI
Campo, F. F.; Brattico, E.; Magalhaes, V.; Nigro, S.; Tafuri, B.; the Alzheimer's Disease Neuroimaging Initiative, ; Logroscino, G.; Cabral, J.
10.1101/2025.01.04.631289 — neuroscience — Posted on 2025-01-04
4750 Seagrass arabinogalactan-proteins: Are they important for adaptation to the marine environment?
Pfeifer, L.; Johnson, K. L.; Bacic, A.; Reusch, T. B. H.; Duarte, C. M.; Sinclair, E. A.; Classen, B.
10.1101/2025.01.03.631252 — plant biology — Posted on 2025-01-04
4752 Biofilm Forming Capacity, Sanitizer Tolerance and Genetic Characterization of Persistent and Non-Persistent Listeria monocytogenes from Artisanal Cheese Processing Environments
Aboagye, E. F.; Forauer, E. C.; Gilmour, A. J.; Blackwell, H. L.; Cushman, L.; Herren, C. S.; Denaro, S. C.; Felten, L.; Ballard, M.; Etter, A. J.
10.1101/2025.01.03.631244 — microbiology — Posted on 2025-01-04
4753 Parenteral Vaccination with recombinant EtpA glycoprotein impairs enterotoxigenic E. coli colonization
Vickers, T. J.; Buckley, D.; Khatoon, N.; Sheikh, A.; Setu, B.; Berndsen, Z. T.; Fleckenstein, J. M.
10.1101/2025.01.03.631264 — microbiology — Posted on 2025-01-04
4755 T Lymphocyte-Specific Deletion of SHP1 and SHP2 Promotes Activation-Induced Cell Death of CD4+ T Cells and Impairs Antitumor Response
Foster, C. J.; Du, J.; Pundel, O.; Geer, M. J.; Ripert, R. C.; Liu, J.; Heim, T. A.; Araki, K. Y.; Lund, A. W.; Wang, J.; Neel, B. G.
10.1101/2025.01.03.631277 — immunology — Posted on 2025-01-04
4757 Laser speckle contrast imaging of hepatic microcirculation
Zhukov, O.; Postnov, D. D.; Hejn, K. H.; Ravnskjaer, K.; Sosnovtseva, O.
10.1101/2024.12.24.629390 — physiology — Posted on 2025-01-04
4758 Development of Proton Density Fat Fraction Micro-MRI for Non-Invasive Quantitative Assessment of Bone Marrow Changes with Age and Radiation in Mouse Models
Ghimire, H. M.; Malekzadeh, M.; Lim, J. E.; Madabushi, S. S.; Zampini, M. A.; Camacho, A.; Hu, W.; Storme, G.; Malki, M. M. A.; Hui, S. K.
10.1101/2025.01.03.631267 — biophysics — Posted on 2025-01-04
4759 Identification and Characterization of Novel Outer Membrane Proteins of Brachyspira pilosicoli
Panda, A.; Kapoor, J.; Hareramadas, B.; Naqvi, I.; Chhabra, R.; Kumar, S.; Bandyopadhyay, A.
10.1101/2025.01.03.631275 — bioinformatics — Posted on 2025-01-04
4761 Genetics and Environment Distinctively Shape the Human Immune Cell Epigenome
Wang, W.; Hariharan, M.; Ding, W.; Bartlett, A.; Barragan, C.; Castanon, R.; Rothenberg, V.; Song, H.; Nery, J.; Aldridge, A.; Altshul, J.; Kenworthy, M.; Liu, H.; Tian, W.; Zhou, J.; Zeng, Q.; Chen, H.; Wei, B.; Gunduz, I. B.; Norell, T.; Broderick, T. J.; McClain, M.; Satterwhite, L.; Burke, T.; Petzold, E.; Shen, X.; Woods, C.; Fowler, V. G.; Ruffin, F.; Panuwet, P.; Barr, D. B.; Beare, J. L.; Smith, A. K.; Spurbeck, R. R.; Vangeti, S.; Ramos, I.; Nudelman, G.; Sealfon, S. C.; Castellino, F.; Walley, A. M.; Evans, T.; Muller, F.; Greenleaf, W. J.; Ecker, J. R.
10.1101/2023.06.29.546792 — genomics — Posted on 2025-01-04
4767 Developing a model system to sustain ex vivo chloroplast function
Mohagheghi, M. V.; Navid, A.; Mossington, T.; Ye, C.; Coleman, M. A.; Hoang-Phou, S.
10.1101/2025.01.03.631265 — bioengineering — Posted on 2025-01-04
4768 An mTOR Inhibitor Discovery System Using Drug-Sensitized Yeast
Breen, A. K.; Thomas, S.; Beckett, D.; Agsalud, M.; Gingras, G.; Williams, J.; Wasko, B. M.
10.1101/2025.01.03.631268 — molecular biology — Posted on 2025-01-04
4769 Early Noise Exposure and Changes in Medial Olivocochlear Strength Alters Auditory Pathway Development
Castagna, V. C.; Boero, L. E.; Di Guilmi, M. N.; Fuchs, P. A.; Lauer, A. M.; Elgoyhen, A. B.; Gomez-Casati, M. E.
10.1101/2025.01.03.631257 — neuroscience — Posted on 2025-01-04
4771 Antidepressants promote developmental-like plasticity through remodeling of extracellular matrix
Nguyen, P. T.; Tamura, S.; Sun, E.; Shi, Y.; Xiao, Y.; Lacefield, C.; Turi, G.; Hen, R.
10.1101/2025.01.03.631260 — neuroscience — Posted on 2025-01-04
4775 Synergizing Network Pharmacology and Pan-Cancer Analysis in TCM Repositioning for Tumor Therapy
Yang, D.; Hu, X.; Liu, Y.; Liao, Y.; Fahira, A.; Wang, L.; Shahab, M.; Ouyang, D.; Kuang, W.; Huang, Z.
10.1101/2025.01.03.631162 — bioinformatics — Posted on 2025-01-04
4776 Hydrogen-bonded organic framework nanotransducers enabled sono-optogenetics for Parkinsonian rats
Wang, W.; Pyatnitskiy, I.; Shi, Y.; Tang, K. W. K.; Xie, Y.; Wynn, T.; Liu, X.; Hsieh, J.-C.; Jeong, J.; He, W.; Artman, B.; Lozano, A. R.; Shi, X.; Sangani, A.; Fenno, L.; Santacruz, S.; Chen, B.; Wang, H.
10.1101/2025.01.03.631271 — bioengineering — Posted on 2025-01-04
4777 Proteomic profiling of advanced hepatocellular carcinoma identifies predictive signatures of response to treatments
Delamarre, A.; Decraecker, M.; Blanc, J.-F.; Di-Tommaso, S.; Dourthe, C.; Dupuy, J.-W.; Moreau, M.; Allain, N.; Mahouche, I.; Giraud, J.; Benard, g.; Lalou, C.; Pinson, B.; Bioulac-Sage, P.; Toulouse, C.; Morisset, A.; Boursier, J.; Le Bail, B.; Raymond, A.-A.; Saltel, F.
10.1101/2025.01.03.631224 — cancer biology — Posted on 2025-01-04
4780 The WRC domain of GRF transcription factors. Structure and DNA recognition
Biglione, F. A.; Palatnik, J. F.; Gonzalez Schain, N. D.; Rasia, R. M.
10.1101/2025.01.03.631214 — biophysics — Posted on 2025-01-04
4786 Strategic Conservation Prioritization Through Creating and Updating the Regional Species of Greatest Conservation Need (RSGCN) List in the Northeastern U.S.
Starking, M. D.; Rice, T. M.; Terwilliger, K.; Drummey, D.; Frantz, M.; Haffner, C. D.; Hess, B.; Holst, L.; Marchand, M.; Burgio, K. R.
10.1101/2025.01.03.631241 — ecology — Posted on 2025-01-04
4787 Dynamic remodeling of centrioles and the microtubule cytoskeleton in the lifecycle of chytrid fungi
Long, A. F.; Vasudevan, K.; Swafford, A. J. M.; Venard, C. M.; Stajich, J. E.; Fritz-Laylin, L. K.; Feldman, J. L.; Stearns, T.
10.1101/2025.01.03.631223 — cell biology — Posted on 2025-01-04
4788 ORP2 regulates free cholesterol accumulation in hepatocytes during MASH
Wu, J.; Zhao, Y.; Qiu, L.; Liang, Y.; Chen, Q.; Wang, X.; Gu, J.; Wang, H.; Liu, Y.; Wu, X.; Chen, S.; Chen, F.-J.; Gao, M.; Yang, H.
10.1101/2025.01.03.631227 — cell biology — Posted on 2025-01-04
4789 AFM-based nanoscale characterization of physical interaction within hematopoietic stem cells niche at single-cell level
Kubiak, A. J.; Bryniarska-Kubiak, N.; Eren, M.; Kowalski, K.; Gawlinska, K.; Kwiecinska, P.; Biarnes-Pelicot, M.; Dessard, M.; El Husseiny, J.; N-Guyen, T.-T.; Kozuch, P.; Lis, O.; Targosz-Korecka, M.; Puech, P.-H.; Szade, K.
10.1101/2025.01.03.627171 — cell biology — Posted on 2025-01-04
4790 RBPscan: A Quantitative, In Vivo Tool for Profiling RNA-Binding Protein Interactions
Kretov, D. A.; Sanborn, O.; McIsaac, T.; Park, E.; Imrat, I.; Wu, S.; Cifuentes, D.
10.1101/2025.01.03.631239 — molecular biology — Posted on 2025-01-04
4793 Valence-dependent sensory-rhythmic neural entrainment modulates cortico-subcortical dynamics, attention, and memory
Hoyer, R. S.; Bernier, M.-F.; Martineau, L.; Lessard Bonaventure, P.; Labelle, C.; Borderie, A.; Blanchette, I.; Blumenthal, A.; Albouy, P.
10.1101/2025.01.03.631218 — neuroscience — Posted on 2025-01-03
4794 Human iPSC-based coculture model reveals neuroinflammatory crosstalk between microglia and astrocytes
Tujula, I.; Hyvärinen, T.; Lotila, J.; Rogal, J.; Voulgaris, D.; Sukki, L.; Tornberg, K.; Korpela, K.; Jäntti, H.; Malm, T.; Herland, A.; Kallio, P.; Narkilahti, S.; Hagman, S.
10.1101/2025.01.03.628608 — neuroscience — Posted on 2025-01-03
4795 Transcriptomic analysis of repeat expansion-ataxias uncovers distinct non-neuronal cell type-specific signatures of disease across the human brain
Chen, Z.; Hicks, A.; Brenton, J.; Grant-Peters, M.; Reynolds, R. H.; Gustavsson, E. K.; Rocca, C.; Rocamora-Perez, G.; Garza, R.; Garcia-Ruiz, S.; Dominik, N.; Anderson, C.; Curless, T.; Montgomery, K.; Macpherson, H.; Nethisinghe, S.; Gavriouchkina, D.; Blunskyte-Hendley, M.; Fairbrother-Browne, A.; Lee, J.; Luo, H.; Efthymiou, S.; Murphy, D.; Hinton, F.; Botia, J. A.; Cortese, A.; Wood, N.; Giunti, P.; Hardy, J.; Jakobsson, J.; Gandhi, S.; Tucci, A.; McLean, C.; Jaunmuktane, Z.; Houlden, H.; Ryten, M.
10.1101/2025.01.03.631007 — neuroscience — Posted on 2025-01-03
4796 Circadian Rhythms are Disrupted in Patients and Preclinical Models of Machado-Joseph Disease
Ribeiro, R. F.; Pereira, D.; Lopes, S. M.; Reis, T.; Silva, P.; Lobo, D.; Gaspar, L.; Duraes, J.; Fernandes, A. R.; Ferreira-Marques, M.; Carvalhas-Almeida, C.; Peca, J.; Alvaro, A. R.; Santana, I.; Santana, M. M.; Silva, M. M. C.; Pereira de Almeida, L.; Cavadas, C.
10.1101/2025.01.03.631212 — neuroscience — Posted on 2025-01-04
4797 Convergent state-control of endogenous opioid analgesia
Kimmey, B. A.; Ejoh, L.; Shangloo, L.; Wojick, J. A.; Chehimi, S. N.; McCall, N. M.; Oswell, C. S.; Mahmood, M.; Yang, L.; Samineni, V. K.; Ramakrishnan, C.; Deisseroth, K.; Crist, R. C.; Reiner, B. C.; Tian, L.; Corder, G.
10.1101/2025.01.03.631111 — neuroscience — Posted on 2025-01-04
4798 Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation
Yang, X.; Jeong, D.; Madeo, G.; Kumbhar, R.; Wang, N.; Niu, L.; Hu, J.; Li, S.; Gadhave, K.; Chen, R.; Akkentli, F.; Workman, C. J.; Vignali, D. A. A.; Ying, M.; Bonci, A.; Dawson, V. L.; Dawson, T.; Mao, X.
10.1101/2025.01.03.631221 — neuroscience — Posted on 2025-01-04
4799 TSPO-PET Reveals Higher Inflammation in White Matter Disrupted by Paramagnetic Rim Lesions in Multiple Sclerosis
Tozlu, C.; Jamison, K. W.; Kang, Y.; Hurtado Rua, S.; Kaunzner, U. W.; Nguyen, T.; Kuceyeski, A.; Gauthier, S. A.
10.1101/2025.01.03.627857 — neuroscience — Posted on 2025-01-04
4800 Linking neural population formatting to function
Ruff, D. A.; Markman, S. K.; Kim, J. Z.; Cohen, M. R.
10.1101/2025.01.03.631242 — neuroscience — Posted on 2025-01-04
4801 DANCE: An open-source analysis pipeline and low-cost hardware to quantify aggression and courtship in Drosophila
Yadav, R. S. P.; Dey, P.; Ansari, F.; Kottat, T.; Prabhu, P. P.; Vasam, M.; Ayyangar, S.; Bhaskar S, S.; Prabhu, K.; Ghosh, M.; Agrawal, P.
10.1101/2025.01.03.631168 — neuroscience — Posted on 2025-01-04
4802 An ultra-long heavy chain bovine antibody neutralizes SARS-CoV-2 and reacts broadly with sarbecoviruses.
Tsoleridis, T.; Fan, C.; Park, E. J.; Duncan, J. D.; Sharma, P.; Wartnaby, S.; Chappell, J. G.; Kipar, A.; Bentley, E. G.; Kirby, A.; Han, X.; Coleman, C. M.; Flyak, A. I.; McClure, C. P.; Rho, S.; Johansson, D. X.; Persson, M. A. A.; Tarr, A. W.; Haig, D.; Stewart, J. P.; Bjorkman, P. J.; Urbanowicz, R. A.; Ball, J. K.
10.1101/2025.01.03.631215 — immunology — Posted on 2025-01-03
4808 Adult patients with autoinflammation of unknown origin partially phenocopy the immune presentation of Still's disease
Veiga, R.; De Vuyst, L.; Neumann, J.; Bucken, L.; Prezzemolo, T.; Willemsen, M.; Vanderschueren, S.; Matthys, P.; Immunome Project Consortium for Autoinflammatory Disorders (ImmunAID), ; Wouters, C.; Humblet-Baron, S.; Liston, A.
10.1101/2024.11.27.625689 — immunology — Posted on 2025-01-03
4812 Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cells
Ward, A. V.; Riley, D.; Cosper, K. E.; Finlay-Schultz, J.; Brechbuhl, H. M.; Libby, A. E.; Hill, K. B.; Varshney, R. R.; Kabos, P.; Rudolph, M. R.; Sartorius, C. A.
10.1101/2024.05.30.596684 — cancer biology — Posted on 2025-01-03
4813 Benchmarking residue-resolution protein coarse-grained models for simulations of biomolecular condensates
Feito, A.; Sanchez-Burgos, I.; Tejero, I.; Sanz, E.; Rey, A.; Collepardo-Guevara, R.; Tejedor, A. R.; Espinosa, J. R.
10.1101/2024.08.28.610132 — biophysics — Posted on 2025-01-03
4814 Structural basis of directionality control in large serine integrases
Shin, H.; Pigli, Y.; Pena Reyes, T.; Fuller, J. R.; Olorunniji, F. J.; Rice, P.
10.1101/2025.01.03.631226 — biochemistry — Posted on 2025-01-03
4816 Ultra-sensitive detection of Phytophthora pluvialis by real-time PCR targeting a mitochondrial gene
O'Neill, R. A.; McLay, E.; Leite, L. N.; Panda, P.; Perez-Sierra, A.; Eacock, A.; Le Boldus, J. M.; Stamm, E.; Fraser, S.; McDougal, R. L.
10.1101/2024.12.18.629255 — microbiology — Posted on 2025-01-03
4817 Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation
Kwaku, G.; Simaku, P.; Jensen, K. N.; Floyd, D.; Saelens, J.; Reardon, C.; Ward, R.; Basham, K.; Hepworth, O.; Vyas, T.; Zamith Miranda, D.; Nosanchuk, J.; Vyas, J.; Brown Harding, H.
10.1101/2025.01.03.631181 — microbiology — Posted on 2025-01-03
4820 Visual field specializations in mouse dLGN
Cha, K.; Rangel Olguin, A. G.; Sharif, R.; Cook, E. P.; Krishnaswamy, A.
10.1101/2025.01.03.631238 — neuroscience — Posted on 2025-01-03
4822 Direct control of neurovascular function by circulating platelets in healthy older adults
Rossetti, G. M. K.; Dunster, J. L.; Sohail, A.; Williams, B.; Cox, K. M.; Jewett, E.; Benford, E.; Lovegrove, J. A.; Gibbins, J. M.; Christakou, A.
10.1101/2024.05.31.596788 — neuroscience — Posted on 2025-01-03
4824 Phylogeography and genetic structure of the steppe marmot (Marmota bobak Muller, 1776)
Brandler, O. V.; Tambovtseva, V. G.; Tukhbatullin, A. R.; Rumyantsev, V. Y.; Grachov, A. A.; Kapustina, S. Y.
10.1101/2024.12.12.628213 — zoology — Posted on 2025-01-03
4825 In silico analysis of the evolution of root phenotypes during maize domestication in Neolithic soils of Tehuacan
Lopez-Valdivia, I.; Vallebueno-Estrada, M.; Rangarajan, H.; Swarts, K.; Benz, B.; Blake, M.; Sidhu, J. S.; Perez-Limon, S.; Sawers, R. J.; Schneider, H.; Lynch, J.
10.1101/2024.11.18.623787 — plant biology — Posted on 2025-01-03
4826 NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway
Magana-Avila, G. R.; Carbajal-Contreras, H.; Amnekar, R.; Dite, T.; Tellez-Sutterlin, M.; Garcia-Avila, K.; Marquina-Castillo, B.; Lopez-Saavedra, A.; Vazquez, N.; Rojas-Ortega, E.; Delpire, E.; Ellison, D. H.; Alessi, D. R.; Gamba, G.; Castaneda-Bueno, M.
10.1101/2024.12.12.628222 — physiology — Posted on 2025-01-03
4827 EPHA2-dependent Ephrin-B1 signaling supports self-renewal ability and recurrence of oral cancer
R, R. R.; U, S. K.; Shanmugam, G.; Datta, N.; Louis, J. M.; Jeyaram, R. D.; Datta, K. K.; Gowda, H.; Sarkar, M.; Nair, M. G.; Prabhu, J. S.; Shabeer, H.; P G, B.; A, T.; Jose, A.; Maliekal, T. T.
10.1101/2025.01.03.631197 — cancer biology — Posted on 2025-01-03
4834 Xenosiderophore transporter gene expression and clade-specific filamentation in Candida auris killifish infection
Gifford, H.; Bedekovic, T.; Helmstetter, N.; Gregory, J.; Ma, Q.; Brand, A. C.; Wilson, D.; Rhodes, J.; Ramsdale, M.; Kudoh, T.; Farrer, R. A.
10.1101/2024.10.22.619744 — microbiology — Posted on 2025-01-03
4835 Phage detection by a bacterial NLR-related protein is mediated by DnaJ
Conte, A. N.; Ruchel, M. E.; Ridgeway, S. M.; Kibby, E. M.; Nagy, T. A.; Whiteley, A. T.
10.1101/2024.06.04.597415 — microbiology — Posted on 2025-01-03
4836 Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticles
Fan, C.; Keeffe, J. R.; Malecek, K. E.; Cohen, A. A.; West, A. P.; Baharani, V. A.; Rorick, A. V.; Gao, H.; Gnanapragasam, P. N. P.; Rho, S.; Alvarez, J.; Segovia, L. N.; Hatziioannou, T.; Bieniasz, P. D.; Bjorkman, P. J.
10.1101/2025.01.02.631145 — immunology — Posted on 2025-01-03
4837 Tattoo ink induces inflammation in the draining lymph node and impairs the immune response against a COVID-19 vaccine
Capucetti, A.; Falivene, J.; Pizzichetti, C.; Latino, I.; Mazzuchelli, L.; Schacht, V.; Hauri, U.; Raimondi, A.; Virgilio, T.; Pulfer, A.; Mosole, S.; Grau Roma, L.; Baumler, W.; Palus, M.; Renner, L.; Ruzek, D.; Goldman Levy, G.; Foerster, M.; Chahine, K.; Gonzalez, S. F.
10.1101/2024.12.18.629172 — immunology — Posted on 2025-01-03
4842 PERFORMANCE OF FOUR NEWLY RELEASED CASSAVA VARIETIES IN A FALLOWED LAND OVER TWO FARMING SEASONS
Ossai, C. O.; Ojobor, S. A.; Ogwuche, T. O.; Akpeji, S. C.; Alama, I. S.; Diebiru-Ojo, E. M.
10.1101/2025.01.01.631026 — plant biology — Posted on 2025-01-03
4843 ABA-induced MYB transcriptional module regulates the differentiation trajectory of chickpea exodermis
Jo, L.; Kluck, R. M. C.; Buti, S.; Holbein, J.; Chhillar, H.; Ding, P.; Franke, R.; Kajala, K.
10.1101/2025.01.03.631192 — plant biology — Posted on 2025-01-03
4844 Impaired humidity sensing reduces tick survival by preventing water homeostasis
Uhran, M. R.; Onyeagba, K.; Sanderson, S. M.; Hoque, S. F.; Kelley, M.; Smith, E. S.; Oyen, K.; Benton-Anderson, A.; Arya, T.; Ledezma, A.; Almatar, H.; Kennedy, J.; Frigard, R.; Holmes, C. J.; Chen, S.-C.; Olafson, P. U.; Gaff, H. D.; Benoit, J. B.
10.1101/2024.11.06.618166 — physiology — Posted on 2025-01-03
4845 Multi-modal image analysis for large scale cancer tissue studies within IMMUcan
Schulz, D.; Eling, N.; Dorier, J.; Rusakiewicz, S.; Devanand, P.; Daniel, M.; Windhager, J.; Fernandez, B. P.; Deglise, S.; Despland, L.; Benyagoub, A.; Loboda, S.; Sandkuijl, D.; Parsotam, N.; Hong, H. S.; Morfouace, M.; Guex, N.; Coukos, G.; Bodenmiller, B.; Tissot, S.
10.1101/2024.12.16.628597 — cancer biology — Posted on 2025-01-03
4849 A Novel XACT lncRNA Transcript with Functions Transcending X-Chromosome Inactivation.
Zhang, P.; Angles, P. H.; Zhang, H.; Li, T.; Mulet-Lazaro, R.; van IJcken, W. F. J.; Philipsen, S.; Delwel, R.; Gribnau, J.; Huylebroeck, D.; Grosveld, F.; Rougeulle, C.; Mulugeta, E.
10.1101/2025.01.03.631201 — genetics — Posted on 2025-01-03
4851 Nucleus softens during herpesvirus infection
Tervonen, A.; Leclerc, S.; Ruokolainen, V.; Tieu, K.; Lyonnais, S.; Niskanen, H.; Chen, J.-H.; Gupta, A.; Kaikkonen, M. U.; Larabell, C. A.; Muriaux, D.; Mattola, S.; Conway, D. E.; Ihalainen, T. O.; Aho, V.; Vihinen-Ranta, M.
10.1101/2025.01.03.631188 — cell biology — Posted on 2025-01-03
4852 The origin and evolution of the gonococcal beta-lactamase plasmid, and implications for public health
Elsener, T. A.; Cehovin, A.; Philp, C.; Fortney, K. R.; Spinola, S.; Maiden, M. C. J.; Tang, C. M.
10.1101/2025.01.03.631176 — microbiology — Posted on 2025-01-03
4854 Broad-Spectrum Antiviral Efficacy of 7-Deaza-7-Fluoro-2'-C-Methyladenosine Against Multiple Coronaviruses In Vitro and In Vivo
Chaves, I. d. M.; de Souza, F. R. O.; Queiroz-Junior, C. M.; Oliveira, L. C.; Andrade, A. C. d. S.; Costa, V. R. d. M.; Teixeira, D. C.; Santos, F. R. d. S.; Fonseca, T. C. M.; Lacerda, L. d. S. B.; Pereira, R. d. D.; Pimenta, J. C.; Amblard, F.; Schinazi, R. F.; Teixeira, M. M.; Costa, V. V.
10.1101/2025.01.02.631052 — microbiology — Posted on 2025-01-03
4863 Selective attention network in naturalistic auditory scenes is object and scene specific
Wikman, P.; Muukkonen, I.; Kauramaki, J.; Laaksonen, V.; Waris, O.; Petkov, C.; Rauschecker, J.
10.1101/2025.01.03.631190 — neuroscience — Posted on 2025-01-03
4866 Facilitation of Cav3.2 channel gating in pain pathways reveals a novel mechanism of serum-induced hyperalgesia
Sanner, K.; Kawell, S.; Evans, G. J.; Elekovic, V.; Walz, M.; Joksimovic, S. L.; Joksimovic, S. M.; Donald, R. R.; Tomic, M.; Orestes, P.; Feseha, S.; Dedek, A.; Ghodsi, S. M.; Fallon, I. P.; Lee, J.; Hwang, S. M.; Hong, S. J.; Covey, D. F.; Romano, C.; Timic Stamenic, T.; Chemin, J.; Bourinet, E.; Zorumski, C. F.; Mayer, J. P.; Stowell, M. H. B.; Hildebrand, M. E.; Eisenmesser, E. Z.; Jevtovic-Todorovic, V.; Todorovic, S. M.
10.1101/2025.01.03.631165 — neuroscience — Posted on 2025-01-03
4867 APP β-CTF triggers cell-autonomous synaptic toxicity independent of Aβ
Luo, M.; Zhou, J.; Sun, C.; Chen, W.; Fu, C.; Si, C.; Zhang, Y.; Geng, Y.; Chen, Y.
10.1101/2024.07.11.603028 — neuroscience — Posted on 2025-01-03
4871 Comparative study of Ergosterol and 7-dehydrocholesterol and their Endoperoxides: Generation, Identification and Impact in Phospholipid Membranes and Melanoma Cells
Yukuyama, M. N.; Fabiano, K. C.; Inague, A.; Uemi, M.; Lima, R. S.; Diniz, L. R.; Oliveira, T. E.; Iijima, T. S.; Faria, H. O. F.; Santos, R. S.; Nolf, M. F. V.; Chaves-Filho, A. B.; Yoshinaga, M. Y. B.; Junqueira, H. C.; Di Mascio, P.; Baptista, M. d. S.; Miyamoto, S.
10.1101/2024.10.21.619400 — biochemistry — Posted on 2025-01-03
4875 Quantifying the success of prey crypsis, aposematism and evasiveness in avoiding predators attack
Linke, D.; Mejia, J. H.; Navarro, V. N. P. E.; Gohil, P.; Garcia, C. R.; Salinas, L.; Elias, M.; Matos-Maravi, P.
10.1101/2024.10.31.621260 — ecology — Posted on 2025-01-03
4876 Divergent endothelial mechanisms drive arteriovenous malformations in Alk1 and Smad4 loss-of-function
Oppenheim, O.; Giese, W.; Park, H.; Baumann, E.; Ivanov, A.; Beule, D.; Eichmann, A.; Gerhardt, H.
10.1101/2025.01.03.631070 — developmental biology — Posted on 2025-01-03
4877 KMT2d regulates tooth enamel development
Lee, J.-M.; Jung, H.; Tang, Q.; Li, L.; Lee, S.-K.; Lee, J. W.; Kwon, H.-J.
10.1101/2024.08.20.608898 — developmental biology — Posted on 2025-01-03
4878 A novel human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion
Richards, A.; Khalil, A.; Bisht, P.; Whitfield, T. W.; Gao, X.; Kamm, R.; Mooney, D.; Gehrke, L.; Jaenisch, R.
10.1101/2024.12.18.629173 — microbiology — Posted on 2025-01-03
4879 Niche-specific macrophage loss promotes skin capillary aging
Mesa, K. R.; O'Connor, K. A.; Ng, C.; Salvatore, S.; Dolynuk, A.; Rivera Lomeli, M.; Littman, D. R.
10.1101/2023.08.25.554832 — immunology — Posted on 2025-01-03
4880 Maternal type 2 immunity promotes a microchimeric transfer of systemic type 2 immunity to offspring.
Gabier, M.; Darby, M.; Chetty, A.; Taliep, A.; Cook, P.; Ryffel, B.; Oudhoff, M.; Dewals, B.; Cunningham, A.; Hickey, E.; Horsnell, W.
10.1101/2025.01.03.631175 — immunology — Posted on 2025-01-03
4881 Erasable Hippocampal Neural Signatures Predict Memory Discrimination
Kinsky, N. R.; Orlin, D. J.; Ruesch, E. A.; Kim, B.; Coello, S.; Diba, K.; Ramirez, S.
10.1101/2023.02.02.526824 — neuroscience — Posted on 2025-01-03
4882 A computational approach to understanding effort-based decision-making in depression
Valton, V.; Mkrtchian, A.; Moses-Payne, M.; Gray, A.; Kieslich, K.; VanUrk, S.; Samborska, V.; Halahakoon, D. C.; Manohar, S. G.; Dayan, P.; Husain, M.; Roiser, J. P.
10.1101/2024.06.17.599286 — neuroscience — Posted on 2025-01-03
4886 Reducing Cofilin dosage makes embryos resilient to heat stress
Biel, N.; Rashid, F.; Natua, S.; Wang, T.-Y.; Chou, T.-F.; Nguyen, T. V. P.; Golding, I.; Kalsotra, A.; Sokac, A. M.
10.1101/2025.01.02.631102 — developmental biology — Posted on 2025-01-03
4887 Noncanonical PI(4,5)P2 coordinates lysosome positioning through cholesterol trafficking
Loughran, R. M.; Arora, G. K.; Sun, J.; Crabtree, S.; Llorente, A.; Ly, K.; Huynh, R.-L.; Cho, W.; Emerling, B. M.
10.1101/2025.01.02.629779 — cell biology — Posted on 2025-01-03
4890 1,3- and 1,4-linked Polysaccharides Uptake in Intestinal Cells Relies on Clathrin/Dynamin 1/Rab5-dependent Endocytosis
Liao, W.; Cao, D.; Wang, Y.; Du, Z.; Yao, J.; Dou, P.; Zheng, Y.; Wang, Z.; Chen, X.; Wang, P.; Chen, H.; Diao, X.; Wang, K.; Ding, K.
10.1101/2025.01.02.631151 — pharmacology and toxicology — Posted on 2025-01-03
4891 Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in H3K27M-mutant gliomas
Batsios, G.; Taglang, C.; udutha, s.; Gillespie, A. M.; Robinson, S. P.; Phoenix, T.; Mueller, S.; Venneti, S.; Koschmann, C.; Viswanath, P.
10.1101/2025.01.02.631150 — cancer biology — Posted on 2025-01-03
4893 Quantifying the shape of cells - from Minkowski tensors to p-atic order
Happel, L.; Griseldis, O.; Grudtsyna, V.; Jain, H. P.; Sknepnek, R.; Doostmohammadi, A.; Voigt, A.
10.1101/2025.01.03.631196 — biophysics — Posted on 2025-01-03
4895 High-resolution digital dissociation of brain tumors with deep multimodal autoencoder
Sun, J.; Pan, Y.; Lin, T.; Smith, K.; Onar-Thomas, A.; Robinson, G. W.; Zhang, W.; Northcott, P. A.; Li, Q.
10.1101/2025.01.02.631152 — bioinformatics — Posted on 2025-01-03
4896 AncestryHub: A web server for local ancestry analysis
Jiang, S.; Deng, Y.; Li, S.; Liu, C. J.; Luo, J.; Zhu, X.; Song, G. D.; Zhang, K.; Song, Q.; Ma, L.
10.1101/2025.01.02.630692 — bioinformatics — Posted on 2025-01-03
4897 Glassy Surfactants Enable Ultra-High Concentration Biologic Therapeutics
Jons, C. K.; Prossnitz, A. N.; Eckman, N.; Dong, C.; Utz, A.; Appel, E.
10.1101/2024.09.09.612104 — bioengineering — Posted on 2025-01-03
4904 Ancient DNA reveals diverse community organizations in the 5th millennium BCE Carpathian Basin
Szecsenyi-Nagy, A.; Virag, C.; Jakab, K.; Rohland, N.; Ringbauer, H.; Anders, A.; Raczky, P.; Hajdu, T.; Kiss, K.; Szeniczey, T.; Evinger, S.; Keszi, T.; Virag, Z. M.; Cheronet, O.; Mallick, S.; Akbari, A.; Pinhasi, R.; Reich, D.; Siklosi, Z.; Szecsenyi-Nagy, A.
10.1101/2025.01.02.631136 — genomics — Posted on 2025-01-03
4905 Clair3-RNA: A deep learning-based small variant caller for long-read RNA sequencing data
Zheng, Z.; Yu, X.; Chen, L.; Lee, Y.-L.; Xin, C.; Wong, A. O. K.; Jain, M.; Kesharwani, R. K.; Sedlazeck, F. J.; Luo, R.
10.1101/2024.11.17.624050 — bioinformatics — Posted on 2025-01-03
4909 Transplant immunosuppressant therapies induce unique functional changes in lymph node and re-shape gut immune homeostasis
Wu, L.; Kensiski, A.; Gavzy, S.; Song, Y.; Lwin, H. W.; France, M.; Kong, D.; Li, L.; Lakhan, R.; Saxena, V.; Piao, W.; WillsonShirkey, M.; Mas, V.; Lohmsr, B.; Bromberg, J. S.; Ma, B.
10.1101/2025.01.02.631100 — immunology — Posted on 2025-01-03
4910 Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance
Klope, M. T.; Talukder, P.; Blank, B. R.; Chelebieva, S.; Chen, J.; Fontaine, S. D.; Gonciarz, R. L.; Jaishankar, P.; Lee, G. J.; Legac, J.; Mathur, V.; Narayan, A.; Okitwi, M.; Orena, S.; Settineri, N. S.; Tapia, J.; Taremwa, Y.; Tumwebaze, P. K.; Vinod, A.; Burrows, J. N.; Rosenthal, P. J.; Cooper, R. A.; Renslo, A. R.
10.1101/2025.01.02.631109 — pharmacology and toxicology — Posted on 2025-01-03
4917 Targeting Osteosarcoma heterogeneity to improve therapeutic response
Melano, B.; Dinh, T.; Zirak, B.; Karimzadeh, M.; Woo, B. J.; Choi, B.; Goodarzi, H.; Sweet-Cordero, A.
10.1101/2025.01.02.631118 — genomics — Posted on 2025-01-03
4920 NR6A1 is essential for neural crest cell specification, formation and survival
Moore, E. L.; Munoz, W.; Bhatt, S.; Sakai, D.; Achilleos, A.; Zhao, R.; Lamb, M.; Price, A.; Seidel, C.; Tiana, M.; Barral, A.; Clawson, D.; Manzanares, M.; Trainor, P.
10.1101/2025.01.02.630962 — developmental biology — Posted on 2025-01-03
4922 Endothelial Sensitivity to Pro-Fibrotic Signals Links Systemic exposure to Pulmonary Fibrosis
Mobus, L.; Yla-Outinen, L.; Mannino, L.; Migliaccio, G.; Kosunen, K.; Dalessandro, N.; Serra, A.; Greco, D.
10.1101/2025.01.02.631148 — molecular biology — Posted on 2025-01-03
4924 Chloroplast genome editing of Rubisco boosts photosynthesis and plant growth
Yamori, W.; Nakazato, I.; Qu, Y.; Sanga, Y.; Miyata, T.; Uehara, R.; Noto, Y.; Namba, K.; Fukayama, H.; Matsumura, H.; Arimura, S.-i.
10.1101/2025.01.02.631008 — plant biology — Posted on 2025-01-03
4925 Phosphorus Availability Modulates Flowering Time Through Subcellular Reprogramming of bGLU25 and GRP7 in Flowering Plants
Cho, H.; Choi, I.; Bouain, N.; Nawaz, A.; Zheng, L.; Shahzad, Z.; Brandizzi, F.; Rhee, S. Y.; Rouached, H.
10.1101/2025.01.02.631137 — plant biology — Posted on 2025-01-03
4926 FGF12A Regulates Nav1.5 via CaM-regulated and CaM-independent Mechanisms
Woodbury, L. S.; Angsutararux, P.; Marras, M.; Wagner, E. S.; Abella, C.; Li, A.; Silva, J. R.
10.1101/2025.01.02.631125 — biophysics — Posted on 2025-01-03
4929 From Nets to Molecules: A Comparative Study of Stream Fish Diversity Recovery Using Different Sampling Methods in Eastern Amazonia
Rosa, F. d. A. S.; Carvalho, C. O.; Queiroz, A. K. O. d.; Silva, D. J. F.; Barreto, S. B.; Thorbek, B. L. G.; Sales, J. B. d. L.; Mauvisseau, Q.; de Boer, H. J.; Ready, J. S.
10.1101/2025.01.02.631091 — genetics — Posted on 2025-01-03
4930 Role of Cockayne Syndrome B (CSB) Protein in Genome Maintenance in Human Cells under Oxidative Stress
Low, G. K. M.; Ng, G. Y.-Q.; Zeegers, D.; Ting, A.; Gopalakrishnan, K.; Khaw, A. K.; Jayapal, M.; Hande, P.
10.1101/2025.01.02.631021 — cell biology — Posted on 2025-01-03
4931 Recessive but damaging alleles of muscle-specific ribosomal protein gene RPL3L drive neonatal dilated cardiomyopathy
Murphy, M. R.; Ganapathi, M.; Lee, T. M.; Fisher, J. M.; Patel, M. V.; Jayakar, P.; Buchanan, A.; Soni, R. K.; Yin, Y.; Yang, F.; Reilly, M. P.; Chung, W. K.; Wu, X.
10.1101/2025.01.02.630345 — molecular biology — Posted on 2025-01-03
4932 Systematically investigating and identifying bacteriocins in the human gut microbiome
Zhang, D.; Zou, Y.; Shi, Y.; Zhang, J.; Liu, J.; Wu, G.; Zhang, J.; Gao, Y.; Chen, M.; LI, Y.-X.
10.1101/2024.07.15.603639 — microbiology — Posted on 2025-01-03
4934 Norditerpene natural products from subterranean fungi with anti-parasitic activity
Kolas, A.; Rusman, Y.; Maia, A. C. G.; Williams, J.; Fumuso, F. G.; Cotto-Rosario, A.; Onoh, C.; Baggar, H.; Piaskowski, M. L.; Baigorria, C.; Paes, R.; Chakrabarti, D.; Weible, L.; Ojo, K. K.; OConnor, R.; Salomon, C. E.
10.1101/2025.01.02.631097 — microbiology — Posted on 2025-01-03
4939 In vitro FLASH irradiation of A549 lung cancer cells and IMR90 healthy human fibroblasts in the synchrocyclotron room of a clinical proton therapy system
Zazpe, A.; del Monte-Garcia, I.; Palao, N.; Cerron, F.; Cueto-Remacha, M.; Paula Linzoain-Agos, P.; Iniesta-Gonzalez, M.; Quartieri, M.; Cuesta, A. M.; Espana, S.; Velasco, G.; Vera-Sanchez, J. A.; Fraile, L. M.; Mazal, A.; Udias, J. M.; Porras, A.; Bragado, P.; Gutierrez-Uzquiza, A.; Sanchez-Parcerisa, D.
10.1101/2024.11.13.623375 — bioengineering — Posted on 2025-01-03
4942 Assessing the oviposition and larval ecologies of mosquitoes and Stegomyia indices along an urban-rural gradient during ongoing dengue outbreaks in the arboviral hotspots of Cocody-Bingerville, southeastern Cote d'Ivoire
Bire, Y. N.; Zahouli, J. Z. B.; Dibo, J. D. K.; Coulibaly, P. N.; Manouana, P. G.; Mavoungou, J. F.; Hellhammer, F.; Maganga, G. D.; Djogbenou, L. S.; Adegnika, A. A.; Borrmann, S.; Becker, S. C.; Toure, M.
10.1101/2025.01.02.631058 — ecology — Posted on 2025-01-03
4943 Independent regulation of memory and emotion by selective retrieval
Wang, Y.; Zhu, Z.; Subbulakshmi, S.; Li, Y.; Fang, F.; Anderson, M.
10.1101/2025.01.02.631155 — neuroscience — Posted on 2025-01-02
4944 Declarative Memory Through the Lens of Single-Trial Peaks in High-Frequency Power
Dede, A. J. O.; Cross, Z. R.; Gray, S. M.; Kelly, J. P.; Yin, Q.; Vahidi, P.; Asano, E.; Schuele, S. U.; Rosenow, J. M.; Wu, J. Y.; Lam, S. K.; Raskin, J. S.; Lin, J. J.; Kim-McManus, O.; Sattar, S.; Shaikhouni, A.; King-Stephens, D.; Weber, P. B.; Laxer, K. D.; Brunner, P.; Roland, J. L.; Saez, I.; Girgis, F.; Knight, R. T.; Ofen, N.; Johnson, E. L.
10.1101/2025.01.02.631123 — neuroscience — Posted on 2025-01-02
4946 Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure
Kim, S.; Kim, Y. K.; Kim, S.; Choi, Y.-S.; Lee, I.; Joo, H.; Kim, J.; Kwon, M.; Park, S.; Jo, M. K.; Choi, Y.; D'Souza, T.; Jung, J. W.; Zakhem, E.; Lenzini, S.; Woo, J.; Choi, H.; Park, J.; Park, S.-Y.; Kim, G. B.; Nam, G.-H.; Kim, I.-S.
10.1101/2024.05.24.592430 — bioengineering — Posted on 2025-01-02
4952 Tissue-Specific Ablation of Liver Fatty Acid-Binding Protein Induces a Metabolically Healthy Obese Phenotype in Female Mice
Tawfeeq, H. R.; Lackey, A. I.; Zhou, Y.; Diolintzi, A.; Zacharisen, S.; Lau, Y. H.; Quadro, L.; Storch, J.
10.1101/2025.01.02.631082 — physiology — Posted on 2025-01-02
4953 Searching for Sequence Features that Control DNA Cyclizability
Gordiychuk, M.; Park, J.; Basu, A.; Ha, T.; Bialek, W.; Zhang, Y.
10.1101/2025.01.02.631081 — biophysics — Posted on 2025-01-02
4954 Biochemical Profiling and Structural Basis of ADAR1-Mediated RNA Editing
Deng, X.; Sun, L.; Zhang, M.; Basavaraj, R.; Wang, J.; Weng, Y.-L.; Gao, Y.
10.1101/2025.01.02.631069 — biochemistry — Posted on 2025-01-02
4955 An endogenous retroviral element co-opts an upstream regulatory sequence to achieve somatic expression and mobility
Rubanova, N.; Singh, D.; Barolle, L.; Chalvet, F.; Netter, S.; Poidevin, M.; Servant, N.; Bardin, A. J.; Siudeja, K.
10.1101/2025.01.02.631056 — genomics — Posted on 2025-01-02
4957 Mesoscale landscaping of the TRIM protein family reveals a novel human condensatopathy
Singh, H. R.; Sharma, V.; Nijssen, J.; Pozniakovski, A.; Rubin, A.; Liang, L.; Ball, D.; Hong, S.; Gauntner, V.; Yu, G.; Ranga, A.; Salant, D.; Hildebrandt, F.; Hyman, A. A.; Majmundar, A. J.
10.1101/2025.01.02.630836 — cell biology — Posted on 2025-01-02
4958 New isolate genomes and global marine metagenomes resolve ecologically relevant units of SAR11
Freel, K. C.; Tucker, S. J.; Freel, E. B.; Giovannoni, S. J.; Eren, A. M.; Rappe, M. S.
10.1101/2024.12.24.630191 — microbiology — Posted on 2025-01-02
4961 Rate of brain aging associates with future executive function in Asian children and older adults
Cheng, S. F.; Yue, W. L.; Ng, K. K.; Qian, X.; Liu, S.; Tan, T. W. K.; Nguyen, K.-N.; Leong, R. L. F.; Hilal, S.; Cheng, C.-Y.; Tan, A. P.; Law, E. C.; Gluckman, P. D.; Chen, C. L.-H.; Chong, Y. S.; Meaney, M. J.; Chee, M.; Yeo, B. T. T.; Zhou, J. H.
10.1101/2023.11.27.568184 — neuroscience — Posted on 2025-01-02
4963 A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia
Dong, Z.; Sepulveda, H.; Vazquez, L. J. A.; Blouin, C.; Fernandez, J.; Binder, M.; Chou, W.-C.; Tien, H.-F.; Faulkner, G. J.; Myers, S. A.; Patnaik, M.; Rao, A.
10.1101/2024.01.30.578015 — cancer biology — Posted on 2025-01-02
4967 Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes
Wang, S.-T.; Anahtar, M.; Kim, D. M.; Samad, T. S.; Zhang, C. M.; Patel, S.; Ko, H.; Ngambenjawong, C.; Wang, C. S.; Kirkpatrick, J. D.; Kumar, V.; Fleming, H. E.; Bhatia, S. N.
10.1101/2024.12.30.630769 — bioengineering — Posted on 2025-01-02
4969 TGF-β3 Promotes Trophoblast Development via ACSS2-Dependent Permissive Lipid Metabolism
BOFFA, F.; Moncada, M.; Lo Sterzo, M.; Palazzese, L.; Scudieri, A.; Domenicone, M.; Capra, E.; Lazzari, B.; Gioia, L.; Alberio, R.; Iuso, D.; Loi, P.; Czernik, M.
10.1101/2025.01.02.631122 — developmental biology — Posted on 2025-01-02
4970 Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells
Oqua, A. I.; Chao, K.; El Eid, L.; Casteller, L.; Baxter, B. P.; Miguens-Gomez, A.; Barg, S.; Jones, B.; Bernardino de la Serna, J.; Rouse, S. L.; Tomas, A.
10.1101/2024.06.22.600087 — cell biology — Posted on 2025-01-02
4971 Recombinant Pichinde reporter virus as a safe and suitable surrogate for high-throughput antiviral screening against highly pathogenic arenaviruses
Sacramento, C. Q.; Bott, R.; Huang, Q.; Eaton, B.; Postnikova, E.; Sabir, A. J.; Argade, M. D.; Ratia, K.; Anantpadma, M.; Carlier, P. R.; Ly, H.; Liang, Y.; Rong, L.
10.1101/2024.12.19.629433 — microbiology — Posted on 2025-01-02
4972 Warm temperature suppresses plant systemic acquired resistance by intercepting N-hydroxypipecolic acid biosynthesis
Shields, A.; Yao, L.; Rossi, C. A. M.; Collado Cordon, P.; Kim, J. H.; Mudher Abo Al-Timmen, W.; Li, S.; Marchetta, E.; Shivnauth, V.; Chen, T.; He, S. Y.; Xin, X.; Castroverde, C. D.
10.1101/2023.10.31.564368 — plant biology — Posted on 2025-01-02
4975 Non-vectorial Integration of Intersectional Short-Pulse Stimulation Enables Enhanced Deep Brain Modulation and Effective Seizure Control
Foldi, T.; Szoboszlay, M.; Chadaide, Z.; Radics, B.; Horvath, B.; Vecsernyes, E.; Lango, I.; Rafi, P.; Pejin, A.; Barcsai, L.; Kozak, G.; Forgo, N.; Furuglyas, K.; Nagy, O.; Nagy, A. J.; Laszlovszky, T.; Somogyvari, Z.; Lorincz, M. L.; Devinsky, O.; Berenyi, A.
10.1101/2025.01.02.631064 — neuroscience — Posted on 2025-01-02
4976 Real-time fMRI neurofeedback reduces default mode network and auditory cortex functional connectivity in schizophrenia
Zhang, J.; Bauer, C. C. C.; Morfini, F.; Lee, Y.; Stone, L.; Awad, A.; Okano, K.; Hwang, M.; Shinn, A. K.; Niznikiewicz, M. A.; Whitfield-Gabrieli, S.
10.1101/2025.01.02.631107 — neuroscience — Posted on 2025-01-02
4977 Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance
Seto, M.; Clifton, M.; Gomez, M. L.; Coughlan, G.; Gifford, K. A.; Jefferson, A. L.; De Jager, P.; Bennett, D. A.; Wang, Y.; Barnes, L. L.; Schneider, J. A.; Hohman, T. J.; Buckley, R. F.; Dumitrescu, L.
10.1101/2025.01.02.631098 — neuroscience — Posted on 2025-01-02
4982 Decreased auditory cortical activations and altered long-range alpha-band connectivity characterize passive auditory spatial attention in ASD
Osorio, S.; Tan, J.; Levine, G.; Ahlfors, S. P.; Graham, S.; Mamashli, F.; Khan, S.; Joseph, R. M.; Losh, A.; Pawlyszyn, S.; McGuiggan, N. M.; Hamalainen, M. S.; Bharadwaj, H.; Kenet, T.
10.1101/2025.01.02.631088 — neuroscience — Posted on 2025-01-02
4983 Brain Infiltrated Monocyte-Macrophages in a rat model of Temporal Lobe Epilepsy: Revisiting the Pro-Inflammatory Paradigm
Grabon, W.; Gasmi, N.; Lang, A.; Ruiz, A.; Georges, B.; Blot, V.; Ogier, M.; Rheims, S.; Navarro, F. P.; Bezin, L.
10.1101/2025.01.02.631083 — neuroscience — Posted on 2025-01-02
4984 IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice.
Kerr, C. M.; Proctor-Roser, M. A.; Parthasarathy, S.; OConnor, J. J.; Pfannenstiel, J. J.; Orozco, R. C.; Fehr, A. R.
10.1101/2025.01.01.631031 — microbiology — Posted on 2025-01-02
4985 Flexibility in PAM Recognition Expands DNA Targeting in xCas9
Hossain, K. A.; Nierzwicki, L.; Orozco, M.; Czub, J.; Palermo, G.
10.1101/2024.08.26.609653 — biophysics — Posted on 2025-01-02
4988 A nucleotide code governs Lis1's ability to relieve dynein autoinhibition
Geohring, I. C.; Chai, P.; Iyer, B. R.; Ton, W. D.; Yang, J.; Ide, A. H.; George, S. C.; Bagri, J. S.; Baird, S. V.; Zhang, K.; Markus, S. M.
10.1101/2024.12.30.630615 — biochemistry — Posted on 2025-01-02
4989 Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells
Oqua, A. I.; Chao, K.; El Eid, L.; Casteller, L.; Baxter, B. P.; Miguens-Gomez, A.; Barg, S.; Jones, B.; Bernardino de la Serna, J.; Rouse, S. L.; Tomas, A.
10.1101/2024.06.22.600087 — cell biology — Posted on 2025-01-02
4990 Tissue-Like Multicellular Development Triggered by Mechanical Compression in Archaea
Rados, T.; Leland, O.; Escudeiro, P.; Mallon, J.; Andre, K.; Caspy, I.; vonKugelgen, A.; Stolovicki, E.; Nguyen, S.; Patop, I.; Rangel, L. T.; Kadener, S.; Renner, L.; Thiel, V.; Soen, Y.; Bharat, T.; Alva, V.; Bisson, A.
10.1101/2024.10.19.619234 — cell biology — Posted on 2025-01-02
4991 Molecular Landscape of the Mouse Adrenal Gland and Adjacent Adipose by Spatial Transcriptomics
Blatkiewicz, M.; Hryhorowicz, S.; Szyszka, M.; Suszynska-Zajczyk, J.; Pławski, A.; Plewinski, A.; Porzionato, A.; Malendowicz, L. K.; Rucinski, M.
10.1101/2025.01.02.631086 — molecular biology — Posted on 2025-01-02
4992 Passaging Human Tauopathy Patient Samples in Cells Generates Heterogeneous Fibrils with a Subpopulation Adopting Disease Folds
Zeng, Z.; Tsay, K.; Vijayan, V.; Frost, M.; Prakash, S.; Quddus, A.; Albert, A.; Vigers, M.; Srivastava, M.; Woerman, A.; Han, S.
10.1101/2023.07.19.549721 — molecular biology — Posted on 2025-01-02
4993 Decoding Secondary Motor Cortex Neuronal Activity during Cocaine Self-Administration: Insights from Longitudinal in vivo Calcium Imaging
Chen, Y.; Fu, H.; Korada, A.; Lange, M. A.; Rayanki, C.; Montgomery, J. M. F.; Lu, T.; Lai, D.; Fang, S.; Guo, C.; MA, Y.-Y.
10.1101/2024.05.20.594996 — neuroscience — Posted on 2025-01-02
4994 CLN5 deficiency impairs glucose uptake in Batten disease
Marchese, M.; Bernardi, S.; Vivarelli, R.; Doccini, S.; Santucci, L.; Ogi, A.; Licitra, R.; Zang, J.; Soliymani, R.; Mero, S.; Neuhauss, S. C.; Signore, G.; Lalowski, M. M.; Santorelli, F. M.
10.1101/2025.01.02.630719 — neuroscience — Posted on 2025-01-02
4995 Combined statistical-mechanistic modeling links ionchannel genes to physiology of cortical neuron types
Bernaerts, Y.; Deistler, M.; Goncalves, P. J.; Beck, J.; Stimberg, M.; Scala, F.; Tolias, A. S.; Macke, J. H.; Kobak, D.; Berens, P.
10.1101/2023.03.02.530774 — neuroscience — Posted on 2025-01-02
4998 The Regulatory Logic of Planarian Stem Cell Differentiation
Perez-Posada, A.; Garcia-Castro, H.; Emili, E.; Vanni, V.; Arias-Baldrich, C.; Frölich, S.; van Heeringen, S. J.; Kenny, N. J.; Solana, J.
10.1101/2024.08.23.608747 — systems biology — Posted on 2025-01-02
4999 Data-Independent Acquisition Mass Spectrometry as a Tool for Metaproteomics: Interlaboratory Comparison Using a Model Microbiome
Rajczewski, A. T.; Blakeley-Ruiz, J.; Meyer, A.; Vintila, S.; Mcilvin, M. R.; Van Den Bossche, T.; Searle, B. C.; Griffin, T.; Saito, M.; Kleiner, M.; Jagtap, P.
10.1101/2024.09.18.613707 — systems biology — Posted on 2025-01-02
5001 WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer
Citron, F.; Ho, I.-L.; Balestrieri, C.; Liu, Z.; Yen, E.-Y. N.; Cecchetto, L.; Perelli, L.; Zhang, L.; Castillo Montanez, L. A.; Blazanin, N.; Dyke, C. A.; Shah, R.; Attanasio, S.; Srinivasan, S.; Chen, K.-C.; Chen, Z.; Scognamiglio, I.; Pham, N.; Khan, H.; Jiang, S.; Pan, J.; Vanderkruk, B.; Leung, C.; Mattohti, M.; Rai, K.; Chu, Y.; Wang, L.; Gao, S.; Deem, A. K.; Carugo, A.; Wang, H.; Yao, W.; Tonon, G.; Xiong, Y.; Lorenzi, P. L.; Bonini, C.; Zal, A.; Hoffman, B.; Giuliani, V.; Heffernan, T.; Jeter, C. R.; Lissanu, Y.; Genovese, G.; Di Pilato, M.; Viale, A.; Draetta, G. F.
10.1101/2024.10.21.619543 — cancer biology — Posted on 2025-01-02
5002 Direct RNA sequencing (RNA004) allows for improved transcriptome assessment and near real-time tracking of methylation for medical applications
Hewel, C.; Wierczeiko, A.; Miedema, J.; Hofmann, F.; Weissbach, S.; Dietrich, V.; Friedrich, J.; Holthoefer, L.; Haug, V.; Muendnich, S.; Schartel, L.; Jenson, K.; Diederich, S.; Sys, S.; Butto, T.; Paul, N.; Koch, J.; Lyko, F.; Kraft, F.; Schweiger, S.; Lemke, E. A.; Helm, M.; Linke, M.; Gerber, S.
10.1101/2024.07.25.605188 — bioinformatics — Posted on 2025-01-02
5003 Protein CREATE enables closed-loop design of de novo synthetic protein binders
Lourenco, A. L.; Subramanian, A. M.; Spencer, R. K.; Miao, J.; Anaya, M.; Fu, W.; Chow, E. D.; Thomson, M.
10.1101/2024.12.20.629847 — bioengineering — Posted on 2025-01-02
5004 A Cell-Permeable Fluorescent Probe Reveals Temporally Diverse PI(4,5)P2 Dynamics Evoked by Distinct GPCR Agonists in Neurons
Kundu, R.; Mondal, S.; Kapadia, A.; Banerjee, A. A.; Kucherak, O. A.; Klymchenko, A. S.; Koushika, S. P.; Venkatramani, R.; Vaidya, V. A.; Datta, A.
10.1101/2024.06.17.599302 — biochemistry — Posted on 2025-01-02
5005 Genomic signals of local adaptation in Eleginops maclovinus from Northern Chilean Patagonia
Claure, C. E.; McKinney, G. J.; Rocha, J. D.; Yanez, J. M.; Perez-Santos, I.; Canales-Aguirre, C. B.
10.1101/2024.12.20.629640 — evolutionary biology — Posted on 2025-01-02
5006 An in-depth dataset of northwestern European arthropod life histories and ecological traits
Logghe, G.; Batsleer, F.; Maes, D.; Permentier, T.; Berg, M. P.; Brosens, D.; Cooleman, S.; De Smedt, P.; Hagge, J.; Lambrechts, J.; Pollet, M.; Verheyde, F.; Bonte, D.
10.1101/2024.12.17.628846 — ecology — Posted on 2025-01-02
5008 Brain signal complexity and aperiodicity predict human corticospinal excitability
Frohlich, J.; Ruch, S.; Trunk, B. H.; Keute, M.; Mediano, P. A. M.; Gharabaghi, A.
10.1101/2024.02.09.579457 — neuroscience — Posted on 2025-01-02
5010 Awakening of the RuMP cycle for partial methylotrophy in the thermophile Parageobacillus thermoglucosidasius
Paredes-Barrada, M.; Mathissen, A. S.; van der Molen, R. A.; Jimenez-Huesa, P. J.; Polano, M. E.; Donati, S.; Abele, M.; Ludwig, C.; van Kranenburg, R.; Claassens, N. J.
10.1101/2024.10.31.621308 — synthetic biology — Posted on 2025-01-02
5012 Sustained efficacy of CRISPR-Cas13b gene therapy for FSHD is challenged by immune response to Cas13b
Rashnonejad, A.; Farea, M.; Chermahini, G. A.; COULIS, G.; Taylor, N.; Fowler, A.; Villalta, A.; King, O. D.; Harper, S. Q.
10.1101/2024.12.18.629250 — molecular biology — Posted on 2025-01-02
5013 IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice.
Kerr, C. M.; Proctor-Roser, M. A.; Parthasarathy, S.; OConnor, J. J.; Pfannenstiel, J. J.; Orozco, R. C.; Fehr, A. R.
10.1101/2025.01.01.631031 — microbiology — Posted on 2025-01-02
5014 Protection Against Pneumonia Induced By Vaccination With Fimbriae Subunits From Klebsiella pneumoniae
Assoni, L.; Ciaparin, I.; Trentini, M. M.; Baboghlian, J.; Rodrigo, G.; Ferreira, B. V.; Pereira, J. A.; Martinez, C. A. R.; Caldas Ferraz, L. F.; Girardello, R.; Carvalho, L. M.; Hakansson, A. P.; Converso, T. R.; Darrieux, M.
10.1101/2025.01.02.631074 — immunology — Posted on 2025-01-02
5015 Visual experience contributes to separation of face and language responses in the ventral stream
Saccone, E. J.; LNU, A.; Murty, N. A. R.; Kim, J. S.; Tian, M.; KANWISHER, N. G.; Bedny, M.
10.1101/2024.12.18.629198 — neuroscience — Posted on 2025-01-02
5018 Precise calcium-to-spike inference using biophysical generative models
Broussard, G. J.; Diana, G.; Urra Quiroz, F. J.; Sermet, B. S.; Lynch, L. A.; DiGregorio, D. A.; Wang, S. S.- H.
10.1101/2024.12.31.630967 — neuroscience — Posted on 2025-01-02
5021 MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia
Pastoors, D.; Havermans, M.; Mulet-Lazaro, R.; Smeenk, L.; Ottema, S.; Erpelinck, C.; Herk, S. V.; Anthonissen, M.; Grob, T.; Wouters, B.; Beverloo, B.; Haferlach, T.; Haferlach, C.; Zuber, J.; Bindels, E.; Delwel, R.
10.1101/2025.01.02.631046 — cancer biology — Posted on 2025-01-02
5023 Actin and vimentin jointly control cell viscoelasticity and compression stiffening
Conboy, J. P.; Lettinga, M. G.; Boukany, P.; MacKintosh, F. C.; Koenderink, G. H.
10.1101/2025.01.01.630993 — biophysics — Posted on 2025-01-02
5024 TOGGLE identifies fate and function process within a single type of mature cell through single-cell transcriptomics
Chen, J.; Jiang, E.; Chen, Z.; Liu, K.; Sun, T.; Nong, Y.; Kong, Y.; Yuan, T.; Daga, P.; Dai, C. C.; Yan, Y.; Ge, J.; Wu, H.; Yang, T.; Wang, S.; Su, Z.; Li, C.; Li, Y.; Yang, K.; Singhal, R. A.; Carll, A. P.
10.1101/2025.01.01.631041 — bioinformatics — Posted on 2025-01-02
5026 Orally Delivered Milk-Derived Nanovesicles Loaded with Connexin 43 Peptides forTargeted Cardiac Ischemia-Reperfusion Therapy
Marsh, S. R.; Amin, R.; Toldo, S.; Beard, C.; Dogan, A. B.; Andres, E.; Mezzaroma, E.; Stout, R.; Bannon, M. S.; Payne, L. B.; Abbate, A.; Sassi, Y.; Letteri, R. A.; Gourdie, R. G.
10.1101/2025.01.01.630994 — bioengineering — Posted on 2025-01-02
5030 LCORL and STC2 variants increase body size and growth rate in cattle and other animals
Bai, F.; Cai, Y.; Qiu, M.; Liang, C.; Pan, L.; Liu, Y.; Feng, Y.; Cao, X.; Yang, Q.; Ren, G.; Jiao, S.; Gao, S.; Lu, M.; Wang, X.; Heller, R.; Lenstra, J. A.; Jiang, Y.
10.1101/2025.01.01.630985 — genetics — Posted on 2025-01-02
5031 Halting predicted vertebrate declines requires tackling multiple drivers of biodiversity loss
Capdevila, P.; O'Brien, D.; Marconi, V.; Johnson, T. F.; Freeman, R.; McRae, L.; Clements, C. F.
10.1101/2025.01.02.630023 — ecology — Posted on 2025-01-02
5032 Impact of Low-Dose Narrowband UV Radiation on Skin Tissue and Mast Cells in a Canine Model
Maeda, Y.; Kubota, S.; Kawarai, S.; Okuyama, H.; Kamimura, M.; Ono, M.; Nishida, M.; Moriya, S.; Onoda, Y.; Tsurumoto, T.; Nagata, K.; Ansai, S.-i.; Fujikawa, Y.; Tsukamoto, A.
10.1101/2025.01.01.631029 — immunology — Posted on 2025-01-02
5033 CD38 expression by neonatal human naïve CD4+ T cells shapes their distinct metabolic state and high regulatory T cell potential
Dwyer, L. R.; Clancy, S.; Gouirand, V.; Chien, C.; Rogers, E. E.; Oltman, S. P.; Jelliffe-Pawlowski, L. L.; Lynch, S. V.; Wagner, A.; Combes, A. J.; Scharschmidt, T. C.
10.1101/2025.01.02.631038 — immunology — Posted on 2025-01-02
5034 Sleep patterns predicting stress resilience are dependent on sex
Bush, B. J.; Mohamed, A.; Andrews, E.-J.; Cain, G.; Fawole, A.; Johnson, H.; Arocho, A.; Qiao, Z.; Paul, K. N.; Ehlen, J. C.
10.1101/2024.12.30.630808 — neuroscience — Posted on 2025-01-02
5036 GENETIC ANALYSIS OF ARABIDOPSIS AUTOPHAGY-RELATED 8 FAMILY PROTEINS REVEALS THEIR REDUNDANT AND REGULATORY ROLES IN PLANT AUTOPHAGY
Dong, K.; Deng, G.; Liu, Y.; Wei, H.; Chen, K.-E.; Huang, X.; Huang, W.; Zheng, P.; Ueda, T.; Vierstra, R. D.; Huang, X.; Li, F.
10.1101/2025.01.01.631040 — plant biology — Posted on 2025-01-02
5039 A tool to dissect heterotypic determinants of homotypic protein phase behavior
Kimbrough, H.; Jensen, J.; Weber, C.; Miller, T.; Maddera, L. E.; Babu, V.; Redwine, W. B.; Halfmann, R.
10.1101/2025.01.01.631016 — biophysics — Posted on 2025-01-02
5040 Conformational dynamics and multi-modal interaction of Paxillin with the Focal Adhesion Targeting Domain
Bhattacharya, S.; He, Y.; Chen, Y.; Mohanty, A.; Grishaev, A.; Kulkarni, P.; Salgia, R.; Orban, J.
10.1101/2025.01.01.630265 — biophysics — Posted on 2025-01-02
5043 A multipurpose microhaplotype panel for genetic analysis of California Chinook salmon
Anderson, E.; Clemento, A.; Campbell, M. A.; Pearse, D. E.; Beulke, A.; Columbus, C.; Campbell, E.; Thompson, N.; Garza, J.-C.
10.1101/2024.12.31.630931 — genetics — Posted on 2025-01-02
5045 Picornaviridae and Caliciviridae diversity in Madagascar fruit bats is driven by cross-continental genetic exchange
Kettenburg, G.; Ranaivoson, H. C.; Andrianiaina, A.; Andry, S.; Henry, A. R.; Davis, R. L.; Laboune, F.; Longtine, E. R.; Godbole, S.; Horigan, S.; Ruhs, E. C.; Raharinosy, V.; Randriambolamanantsoa, T. H.; Lacoste, V.; Heraud, J.-M.; Dussart, P.; Douek, D. C.; Brook, C. E.
10.1101/2024.12.31.630946 — evolutionary biology — Posted on 2025-01-02
5048 In vivo itaconate tracing reveals degradation pathway and turnover kinetics
Cordes, T. F.; Willenbockel, H. F.; Williams, A. T.; Lucas, A.; Dowerg, B.; Cabrales, P.; Metallo, C. M.
10.1101/2025.01.02.629617 — cell biology — Posted on 2025-01-02
5050 Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases
Finney, J.; Kuraoka, M.; Song, S.; Watanabe, A.; Liang, X.; Liao, D.; Moody, M. A.; Walter, E. B.; Harrison, S.; Kelsoe, G. H.
10.1101/2025.01.01.631020 — immunology — Posted on 2025-01-02
5051 Prefrontal dopamine activity is critical for rapid threat avoidance learning
Zeidler, Z. E.; Gomez, M. F.; Gupta, T.; Shari, M.; Wilke, S. A.; DeNardo, L. A.
10.1101/2024.05.02.592069 — neuroscience — Posted on 2025-01-02
5053 Differences in apple fruit shape are independent of fruit size
DeViller, K.; Chitwood, D. H.; Myles, S.; Li, M.; Migicovsky, Z.
10.1101/2025.01.01.631017 — plant biology — Posted on 2025-01-02
5054 Evaluation of Candidate ''Kill or Cure'' Strategies to Treat MFN2-related Lipodystrophy
Luijten, I.; Weng, X.; Kibildyte, U.; Buchan, J.; Onishi, A.; Mann, J.; McKay, E. J.; Savage, D. B.; Semple, R. K.
10.1101/2025.01.01.630797 — physiology — Posted on 2025-01-02
5057 A framework integrating multiscale in-silico modeling and experimental data predicts CD33 CAR-NK cytotoxicity across target cell types
Ahmad, S.; Xing, K.; Rajakaruna, H.; Stewart, W. C.; Beckwith, K.; Nayak, I.; Kararoudi, M. N.; Lee, D. A.; Das, J. J.
10.1101/2024.12.31.630941 — cancer biology — Posted on 2025-01-02
5063 Force Generation by Enhanced Diffusion in Enzyme-Loaded Vesicles
Eberhard, E.; Burger, L.; Pastrana, C. L.; Seyed-Allaei, H.; Giunta, G.; Gerland, U.
10.1101/2025.01.02.627955 — biophysics — Posted on 2025-01-02
5067 Quantitative evaluation of the role of the microenvironment in the phenotype, metabolism, and drug resistance of PDAC tumor organoids
Sorzabal, I.; Morales, X.; Cortes-Dominguez, I.; Esparza, M.; Grande, L.; Castillo, P.; Narayanan, S.; Ponz-Sarvise, M.; Vicent, S.; Ortiz-de-Solorzano, C.
10.1101/2024.12.31.630904 — bioengineering — Posted on 2025-01-02
5070 Molecular basis for the activation of Pseudomonas aeruginosa MsbA by Zn2+
Lyu, J.; Bahramimoghaddam, H.; Zhang, T.; Yadav, G.; Zhao, M.; Russell, D.; Laganowsky, A.
10.1101/2024.12.31.630943 — biochemistry — Posted on 2025-01-02
5074 Non-nucleosomal (CENP-A/H4)2 - DNA complexes as a possible platform for centromere organization
Ali-Ahmad, A.; Mors, M.; Carrer, M.; Li, X.; Bilokapic, S.; Halic, M.; Cascella, M.; Sekulic, N.
10.1101/2024.12.31.630874 — biochemistry — Posted on 2025-01-02
5075 Single-cell mapping of regulatory DNA:Protein interactions
Chi, W. Y.; Yoon, S.-H.; Mekerishvili, L.; Ganesan, S.; Potenski, C.; Izzo, F.; Landau, D.; Raimondi, I.
10.1101/2024.12.31.630903 — genomics — Posted on 2025-01-02
5077 Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis
Xie, Q.; Wu, H.; Qiu, J.; Liu, J.; Lyu, Q.; Long, H.; Li, W.; Zhang, S.; Jiang, X.; Zhou, Y.; Gao, Y.; Hsueh, A. J. W.; Kuang, Y.; Suo, L.
10.1101/2025.01.02.631059 — genetics — Posted on 2025-01-02
5078 Convergent Evolutionary Traces of Genomic Innovations and Depletions in Socially Parasitic Ants
Harrison, M. C.; Seguret, A. C.; Finke, C.; Jongepier, E.; Grandchamp, A.; Stoldt, M.; Heinze, J.; Foitzik, S.; Bornberg-Bauer, E.; Feldmeyer, B.
10.1101/2024.12.31.630940 — evolutionary biology — Posted on 2025-01-02
5080 Experimental assessment of large mammal population estimates from airborne thermal videography
McElhinny, J. S.; Larsen, G. D.; Messinger, M.; Newbolt, C. H.; Whitworth, A.; Ditchkoff, S. S.; Silman, M. R.; Beaver, J. T.
10.1101/2024.12.31.630817 — ecology — Posted on 2025-01-02
5082 Hepatic fructose metabolism is antagonized by growth hormone/insulin-like growth factor signaling via regulation of ketohexokinase expression
Elsaid, S. A.; Meesala, P.; Choi, Y.; Yu, L.; Lazar, M.; Xiao, Y.; Pichel, J. M.; Perez-Matute, P.; Rodrigo, F.; Alaby Pinheiro Faccioli, L.; Sun, Y.; Berryman, D.; List, E. O.; Kopchick, J.; Mayer, D.; Tee, S. S.
10.1101/2025.01.01.630846 — molecular biology — Posted on 2025-01-02
5083 Structure of an LGR dimer - an evolutionary predecessor of glycoprotein hormone receptors
Gong, Z.; Chen, S.; Fu, Z.; Kloss, B.; Wang, C.; Clarke, O. B.; Fan, Q. R.; Hendrickson, W. A.
10.1101/2024.12.31.630923 — molecular biology — Posted on 2025-01-02
5089 The bully phage: A Shiga toxin-encoding prophage interferes with the induction of co-hosted prophages
Litvak, Y.; Hashuel, R.; Wellins, T.; Rachimi, M.; Gutman, E.; Melki, R.; Taktuk, L.; Pash Wasserzug, P.; Avissar, R.; Roitman, K.
10.1101/2025.01.01.630987 — microbiology — Posted on 2025-01-02
5090 The mycomembrane differentially and heterogeneously restricts antibiotic permeation
Lepori, I.; Jackson, K.; Liu, Z.; Chordia, M. D.; Wong, M.; Rivera, S. L.; Roncetti, M.; Poliseno, L.; Pires, M. M.; Siegrist, M. S.
10.1101/2024.12.31.630956 — microbiology — Posted on 2025-01-02
5091 Molecular basis for shifted receptor recognition by an encephalitic arbovirus
Fan, X.; Li, W.; Oros, J.; Plung, J. S.; Plante, J. A.; Basu, H.; Nagappan-Chettiar, S.; Boeckers, J. M.; Tjang, L. V.; Mann, C. J.; Brusic, V.; Buck, T. K.; Varnum, H.; Yang, P.; Malcolm, L. M.; Choi, S. Y.; de Souza, W. M.; Chiu, I. M.; Umemori, H.; Weaver, S. M.; Plante, K. S.; Abraham, J.
10.1101/2025.01.01.631009 — microbiology — Posted on 2025-01-02
5094 Methanogens are associated with altered microbial production of short-chain fatty acids and human-host metabolizable energy
Dirks, B.; Davis, T. L.; Carnero, E. A.; Corbin, K. D.; Smith, S. R.; Rittmann, B. E.; Krajmalnik-Brown, R.
10.1101/2024.12.31.630929 — microbiology — Posted on 2025-01-02
5095 Discrimination between Mycobacterium tuberculosis and Mycobacterium bovis using Fourier Transform Infrared Spectroscopy
Guterres, K. B.; Silva-Pereira, T. T.; Oliveira, R.; Moonen, C. G. J.; Heinemann, M. B.; Araujo, F. R.; Palaci, M.; de Souza, G.; Guimaraes, N. S.; Guimaraes, A. M. S.
10.1101/2025.01.01.631036 — microbiology — Posted on 2025-01-02
5096 A20's Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven Enteritis
Bowman, C. J.; Stibor, D.; Sun, X.; Shimizu, H.; Yamashita, E.; Lenci, N.; Advincula, R.; Kim, M. C.; Turnbaugh, J. A.; Sun, Y.; Razani, B.; Turnbaugh, P. J.; Ye, C. J.; Malynn, B. A.; Ma, A.
10.1101/2024.12.31.630926 — immunology — Posted on 2025-01-02
5098 Aedes aegypti midgut chymotrypsin has no significant role in blood meal protein digestion or fecundity
Rascon, A. A.; Ramirez, A. G.; Isoe, J.; Serafim, M. S. M.; Fong, D.; Le, M. A.; Nguyen, J. T.; Burata, O. E.; Lucero, R. M.
10.1101/2024.12.31.630969 — biochemistry — Posted on 2025-01-02
5100 Promiscuous structural cross-compatibilities between major shell components of Klebsiella pneumoniae bacterial microcompartments
Barthe, L.; Balestrino, D.; Azizi, B.; Dessaux, D.; Soldan, V.; Esque, J.; Schiex, T.; Barbe, S.; Garcia-Alles, L. F.
10.1101/2025.01.01.631032 — biochemistry — Posted on 2025-01-02
5101 Protein Barcoding and Next-Generation Protein Sequencing for Multiplexed Protein Selection, Analysis, and Tracking
Chinnaraj, M.; Huang, H.; Hutchinson, S.; Meyer, M.; Pike, D.; Ribezzi, M.; Sultana, S.; Ocampo, D.; Ding, F.; Carpenter, M. L.; Chorny, I.; Vieceli, J.
10.1101/2024.12.31.630920 — biochemistry — Posted on 2025-01-02
5102 Ether Rhodamines with Enhanced Hydrophilicity, Fluorogenicity, and Brightness for Super-Resolution Imaging
Fang, X.; Qiao, Q.; Li, Z.; Li, H.-K.; Chen, J.; Xu, N.; An, K.; Jiang, W.; Tao, Y.; Bao, P.; Zhang, Y.; Wu, Z.; Liu, X.; Xu, Z.
10.1101/2025.01.02.631033 — biochemistry — Posted on 2025-01-02
5103 The small genome size ensures adaptive flexibility for an alpine ginger
Xiao, Q.-S.; Fer, T.; Guo, W.; Chen, H.-F.; Li, L.; Zhao, J.-L.
10.1101/2024.12.31.630872 — ecology — Posted on 2025-01-02
5106 Chronic Staphylococcus aureus infection of osteocytes promotes an intracellular viable-but-non-culturable phenotype
Gunn, N. J.; Zelmer, A. R.; Kidd, S. P.; Solomon, L. B.; Carda-Dieguez, M.; Mira, A.; Yang, D.; Atkins, G. J.
10.1101/2024.12.17.629047 — microbiology — Posted on 2025-01-02
5112 Selective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept
Hughes, S. J.; Stech, W. J.; Davies, C. T. R.; McGarry, D.; Williams, A.; del Barco Barrantes, I.; Harris, R.; Owens, D. D. G.; Fawcett, A.; Hellicar, J.; Meier, G. P.; Runcie, A. C.; Greger, L.; O'Rourke, M.; Churcher, I.; Pass, M.; Brown, G. A.; Ciulli, A.; Modis, L. K.; Testa, A.
10.1101/2024.12.31.630899 — biochemistry — Posted on 2025-01-02
5115 cOmicsArt - a customizable Omics Analysis and reporting tool
Seep, L.; Jost, P. J.; Lisowski, C.; Huang, H.; Grein, S.; Hermannsdottir, H.; Kuellmer, K.; Fromme, T.; Klingenspor, M.; Mass, E.; Kurts, C.; Hasenauer, J.
10.1101/2024.10.30.621025 — bioinformatics — Posted on 2025-01-02
5121 Perturbing whole-brain models of brain hierarchy: an application for depression following pharmacological treatment
Socoro Garrigosa, M.; Sanz Perl, Y.; Kringelbach, M. L.; Carhart-Harris, R.; Vohryzek, J.; Deco, G.
10.1101/2025.01.01.631011 — neuroscience — Posted on 2025-01-02
5122 Assessing the role of BNST GABA neurons in backward conditioned suppression
Ly, A.; Hotchkiss, H.; Prevost, E. D.; Pelletier, J.; Deming, M.; Murib, L.; Root, D. H.
10.1101/2025.01.01.631006 — neuroscience — Posted on 2025-01-02
5123 The role of STN beta oscillations on lower extremity muscle activity in Parkinsonian stepping
Simpson, T. G.; He, S.; Pogosyan, A.; Rodriguez Plazas, F.; Hart, M. G.; Shah, R.; Hasegawa, H.; Wiest, C.; Wehmeyer, L.; Yassine, S.; Guo, X.; Merla, A.; Perera, A.; Raslan, A.; O'Keeffe, A.; Welter, M.-L.; Ashkan, K.; Morgante, F.; Andrade, P.; Visser-Vandewalle, V.; Pereira, E. A.; Tan, H.
10.1101/2025.01.01.631000 — neuroscience — Posted on 2025-01-02
5124 Convergent and non-additive impact of schizophrenia risk genes in human neurons
Deans, P. M.; Townsley, K. G.; Li, A.; Seah, C.; Johnson, J.; Garcia Gonzalez, J.; Cao, E.; Schrode, N.; Yu, A.; Cartwright, S.; Voloudakis, G.; Zhang, W.; Wang, M.; Fullard, J. F.; Girdhar, K.; Stahl, E.; Akbarian, S.; Zhang, B.; Roussos, P.; O'Reilly, P. F.; Huckins, L. M.; Brennand, K. J.
10.1101/2022.03.29.486286 — neuroscience — Posted on 2025-01-02
5127 A forward-engineered muscle tissue driven soft robotic swimmer
Drennan, W. C.; Aydin, O.; Emon, B.; Li, Z.; JOY, M. S. H.; Barishman, A.; Kim, Y.; Wei, M.; Denham, D.; Carrillo, A.; Saif, M. T. A.
10.1101/2024.10.30.621139 — bioengineering — Posted on 2025-01-02
5129 AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone
Elsheikh, A.; Driggers, C. M.; Truong, H. H.; Yang, Z.; Allen, J.; Henriksen, N.; Walczewska-Szewc, K.; Shyng, S.-L.
10.1101/2024.09.05.611490 — biochemistry — Posted on 2025-01-02
5130 The Rodent Electronic Nicotine Delivery System: Description and Validationof an Apparatus for Nose-Only E-Cigarette Aerosol Inhalation in Freely Moving Rats
Odum, A. L.; Willis-Moore, M. E.; Callister, K. T.; Haynes, J. M.; Frye, C. C. J.; Scribner, L. N.; Legaspi, D. N.; Da Silva, D. S.; Olsen, A. L.; Truscott, T. T.; Alden, P. T.; Bevins, R. A.; Leventhal, A. M.; Lee, S. T.; Gomer, B.
10.1101/2024.12.21.629932 — animal behavior and cognition — Posted on 2025-01-02
5131 Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions Affecting Activation and Autoinhibition
Snyder, L. F.; O'Brien, E. M.; Zhao, J.; Liang, J.; Bruce, B. J.; Zhang, Y.; Zhu, W.; Cassier, T.; Schnicker, N. J.; Zhou, X.; Gordan, R.; He, B. Z.
10.1101/2024.04.20.590343 — evolutionary biology — Posted on 2025-01-02
5133 Genomic signals of local adaptation in Eleginops maclovinus from Northern Chilean Patagonia
Claure, C. E.; McKinney, G. J.; Rocha, J. D.; Yanez, J. M.; Perz-Santos, I.; Canales-Aguirre, C. B.
10.1101/2024.12.20.629640 — evolutionary biology — Posted on 2025-01-02
5135 LIN-67 functionally interacts with heterochronic miRNAs and regulates developmental timing in Caenorhabditis elegans
Medley, J. C.; Perales, R.; Gaete Humada, B.; Doerfel, K.; Levine, A.; Panzade, G.; Hammell, C. M.; Zinovyeva, A.
10.1101/2024.12.31.630947 — developmental biology — Posted on 2025-01-02
5141 Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation
Xu, S.; Buridant, A.; Hirsch, T.; Shafaq-Zadah, M.; Dransart, E.; Ledoux, B.; Johannes, L.; van der Bruggen, P.; Morsomme, P.; Renard, H.-F.
10.1101/2024.10.28.620627 — cell biology — Posted on 2025-01-02
5142 Effect of curcumin and 5-bromoindole-3-carboxyaldehyde on the inhibition of Quorum sensig-dependent virulence factors in Pseudomonas aeruginosa
Gonzalez, G. M.; Garcia-Contreras, R.; ALVARADO SALAZAR, J. A.; Garcia Vales, I.; Valdes, N. G.; Lugo Gutierrez, D. A.; Bustamante Martinez, I. L.; Tescucano Alonso, A. R.; Ramirez-Villalva, A.; Almeida, J.
10.1101/2024.07.29.605599 — microbiology — Posted on 2025-01-02
5145 AA147 Alleviates Symptoms in a Mouse Model of Multiple Sclerosis by Reducing Oligodendrocyte Loss
Asku, M.; Kaschke, K.; Podojil, J. R.; Chiang, M.; Steckler, I.; Bruce, K.; Cogswell, A. C.; Schulz, G.; Kelly, J.; Wiseman, R. L.; Miller, S.; Popko, B.; Chen, Y.
10.1101/2025.01.01.630914 — neuroscience — Posted on 2025-01-02
5146 Neural circuits between nodose ganglion and pulmonary neuroendocrine cells regulate lung inflammatory responses
CHEN, J.; Xie, S.; Lin, Z.; Zhao, C.; Tao, R.; Ma, Y.; Chen, X.; Wu, R.; Sui, P.; Wang, S.; Ji, h.; Song, H.; Zhang, X.; Sun, Y.; Song, Y.; Su, X.
10.1101/2025.01.01.630820 — neuroscience — Posted on 2025-01-02
5148 CaBLAM! A high-contrast bioluminescent Ca2+ indicator derived from an engineered Oplophorus gracilirostris luciferase
Lambert, G. G.; Crespo, E. L.; Murphy, J.; Boassa, D.; Luong, S.; Celinskis, D.; Venn, S.; Nguyen, D. K.; Hu, J.; Sprecher, B.; Tree, M. O.; Orcutt, R.; Heydari, D.; Bell, A. B.; Torreblanca-Zanca, A.; Hakimi, A.; Lipscombe, D.; Moore, C. I.; Hochgeschwender, U.; Shaner, N. C.
10.1101/2023.06.25.546478 — neuroscience — Posted on 2025-01-02
5151 VGluT3 BNST neurons transmit GABA and restrict feeding without affecting rewarding or aversive processing
Ly, A.; Karnosky, R.; Prevost, E. D.; Hotchkiss, H.; Pelletier, J.; Spencer, R. L.; Ford, C. P.; Root, D. H.
10.1101/2025.01.01.631003 — neuroscience — Posted on 2025-01-02
5154 TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress
Shukla, N.; Neal, M.; Farre, J.-C.; Mast, F. D.; Truong, L.; Simon, T.; Miller, L.; Aitchison, J.; Subramani, S.
10.1101/2024.12.31.630809 — cell biology — Posted on 2025-01-02
5155 Chronic degenerative failure of salivary glands can be reversed through restoring mitochondrial function
Li, J.; Tan, L. X.; Sun, B.; Griffin, N.; Niknezhad, S. V.; Yu, C.; Berthoin, L.; Cruz Pacheco, N.; Mohabbat, S.; Sinada, H.; Gaylord, E. A.; Chen, Y. T.; An, L.; Efraim, Y.; Bahney, C. S.; Lombaert, I. M. A.; Knox, S.
10.1101/2024.12.31.630834 — cell biology — Posted on 2025-01-02
5156 A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma.
Jo, H.; Dalvi, A.; Yang, W.; Morozova, E.; Munoz, S.; Glasgow, S. M.
10.1101/2024.12.31.630965 — cell biology — Posted on 2025-01-02
5161 Auditory tract maturation in early infancy: Links to speech production
Liu, F.; Wang, Y.; Gu, J.; Liu, J.; Cai, X.; Zhang, H.; Feng, J.; Wang, Z.; Wu, H.; Shen, D.
10.1101/2024.12.31.630971 — neuroscience — Posted on 2025-01-01
5164 Persistent virulent phages exist in bacterial isolates
Dougherty, P. E.; Bernard, C.; Carstens, A. B.; Stanford, K.; McAllister, T. A.; Rocha, E. P. C.; Hansen, L. H.
10.1101/2024.12.31.630880 — microbiology — Posted on 2025-01-01
5165 Iterative acylation on mature lasso peptides by widespread acetyltransferases for lipolasso production
Xiong, J.; Wu, S.; Liang, Z.-Q.; Fang, S.; Tao, F.-Y.; Gong, X.-T.; Wu, Q.; Cui, J.-J.; Gao, K.; Luo, S.; Lei, D.; Dong, S.-H.
10.1101/2024.12.31.630886 — synthetic biology — Posted on 2025-01-01
5168 Non-nucleosomal (CENP-A/H4)2 - DNA complexes as a possible platform for centromere organization
Ali-Ahmad, A.; Mors, M.; Carrer, M.; Li, X.; Bilokapic, S.; Halic, M.; Sekulic, N.; Cascella, M.
10.1101/2024.12.31.630874 — biochemistry — Posted on 2025-01-01
5170 A third type of PETase from the marine Halopseudomonas lineage
Turak, O.; Gagsteiger, A.; Upadhyay, A.; Kriegel, M.; Salein, P.; Agarwal, S.; Borchert, E.; Höcker, B.
10.1101/2024.12.31.630877 — biochemistry — Posted on 2025-01-01
5172 BORC segregates synaptic vesicle and lysosomal proteins through motors UNC-104/KIF1A and UNC-116/KIF5
Mathew, A.; Seal, S.; Dandekar, A.; Chauhan, B. S.; Sivadasan, S.; Nonet, M. L.; Koushika, S. P.
10.1101/2024.12.31.630845 — cell biology — Posted on 2025-01-01
5174 Flaviviruses Hijack HuR to Suppress CNPY3: A Novel Pathway for Immune Evasion and Therapeutic Intervention
Ding, X.; Li, J.; He, J.; Zhao, J.; Zhou, Y.; Chen, X.; Tong, J.; Quan, W.; Qiu, M.; Hua, D.; Liu, M.; Guan, S.
10.1101/2024.12.31.630865 — microbiology — Posted on 2025-01-01
5181 Clostridium novyi type B causes fatal hemorrhagic disease in wild Asian elephants
Padhi, S. K.; Pahari, A.; Behera, B. K.; Dash, M.; Dash, R.; Sahoo, N.; Nath, I.; Acharaya, A. P.; Panda, S. K.; Mahapatra, S.; Nair, M. V.
10.1101/2024.12.31.630866 — microbiology — Posted on 2025-01-01
5182 T cell-derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses during Viral Infections
Sala, E.; Nelli, M.; Laura, C.; Di Lucia, P.; Beccaria, C. G.; Bono, E. B.; Mangione, M.; Marotta, D.; Sperto, V.; Grillo, M.; Giustini, L.; Nie, J.; Furiato, G.; Malpighi, C.; Consolo, E.; David, E.; Cohen, M.; Giladi, A.; Amit, I.; Bosselut, R.; Guidotti, L. G.; Iannacone, M.; Kuka, M.
10.1101/2024.12.31.630815 — immunology — Posted on 2025-01-01
5183 Distinct region-specific neutralization profiles of contemporary HIV-1 clade C against best-in-class broadly neutralizing antibodies
Sutar, J.; Jayal, P.; Mullick, R.; Chaudhary, S.; Kamble, P.; Bhowmick, S.; Kaginkar, S.; Padwal, V.; Devadiga, P.; Neman, N.; Kitchin, D.; Kaldine, H.; Mkhize, N. N.; Ndlovu, B.; Gounder, K.; Mukherjee, S.; Shrivas, S.; Sharma, N.; Prasad, C.; Tewatia, S.; Parihar, N.; Kumar, N.; Kasarpalkar, N.; Singh, B.; Mohapatra, S.; Aquil, M.; Kumar, C. V.; Dinesha, T. R.; Srikrishnan, A. K.; Shastri, J.; Agrawal, S.; Gaikwad, S.; Mondal, S.; Bandopadhyay, B.; Guha, S. K.; Kale, D.; Biswas, D.; Patil, D.; Paranjape, R. S.; Mukhopadhyay, S.; V, H.; Das, R.; Kondapi, A.; Bhor, V.; Deshpande, S.; Sok, D.;
10.1101/2024.12.31.630867 — immunology — Posted on 2025-01-01
5184 Crosslinker-free in situ hydrogel induces self-aggregation of human dental pulp stem cells with enhanced antibacterial activity
Lee, S. J.; Wu, Z.; Huang, M.; Liang, C.; Huang, Z.; Siyuan, C.; Rajasekar, V.; Abdalla, M. M.; Nah, H.; Heo, D. N.; Kwon, I. K.; Cho, M.-J.; Kim, S. J.; Sohn, S.; Kim, S.-H.; Sugimura, R. R.; Yiu, C. K. Y.
10.1101/2024.12.30.630819 — bioengineering — Posted on 2025-01-01
5186 Fusobacterium nucleatum is enriched in invasive biofilms in colorectal cancer
Queen, J.; Cing, Z.; Minsky, H.; Nandi, A.; Southward, T.; Ferri, J.; McMann, M.; Iyadorai, T.; Vadivelu, J.; Roslani, A.; Loke, M. F.; Wanyiri, J.; White, J. R.; Drewes, J. L.; Sears, C. L.
10.1101/2024.12.30.630810 — microbiology — Posted on 2025-01-01
5189 Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer.
Yoffe, L.; Bhinder, B.; Kang, S. W.; Zhang, H.; Singh, A.; Ravichandran, H.; Markowitz, G. J.; Martin, M.; Kim, J.; Zhang, C.; Elemento, O.; Tansey, W.; Bates, S.; McGraw, T. E.; Borczuk, A.; Lee, H.-S.; Altorki, N. K.; Mittal, V.
10.1101/2024.12.31.630523 — cancer biology — Posted on 2025-01-01
5190 Directionality of two-photon absorption in representative fluorescent proteins
Lazar, J.; Timr, S.; Rybakova, O.; Khoroshyy, P.; Brynda, J.; Thuen, A.; Drobizhev, M.; Myskova, J.
10.1101/2024.12.31.630429 — biophysics — Posted on 2025-01-01
5193 Isoform-level discovery, quantification and fusion analysis from single-cell and spatial long-read RNA-seq data with Bambu-Clump
Sim, A. D.; Ling, M. H.; Chen, Y.; Lu, H.; See, Y. X.; Perrin, A.; Leng Agnes, O. B.; Cao, E. Y.; Chia, B.; Liu, J.; Wüstefeld, T.; Shin, J.; Göke, J.
10.1101/2024.12.30.630828 — bioinformatics — Posted on 2025-01-01
5194 Wavefront estimation through structured detection in laser scanning microscopy
Fersini, F.; Zunino, A.; Morerio, P.; Baldini, F.; Booth, M. J.; Del Bue, A.; Vicidomini, G.
10.1101/2024.12.31.630574 — bioengineering — Posted on 2025-01-01
5198 Argonaute proteins regulate the timing of the spermatogenic transcriptional program
Carro, M. d. l. M.; Dziubek, A.; Touey, A.; Popkowski, E.; Abdelmassih, M.; Simon, L. E.; Tanis, S. L.; Ahmed, F.; Grenier, J. K.; Grimson, A.; Cohen, P. E.
10.1101/2024.12.31.630913 — developmental biology — Posted on 2025-01-01
5199 Dynamic balance of H3K9me2 heterochromatin by CoREST-2 and RE-1 in growing neurons
Drube, J. F.; Cardozo-Gizzi, A.; Rozes-Salvador, V.; Martinez, I.; Ceschin, D. G.; Giordano, L.; Serniotti, L.; Gastaldi, L.; Remedi, M.; Moyano, A. L.; Caceres, A.; Wilson, C.
10.1101/2024.12.31.629745 — cell biology — Posted on 2025-01-01
5200 ZapA employs a two-pronged mechanism to facilitate Z ring formation in Escherichia coli
Cui, Y.; Gong, H.; Yan, D.; Li, H.; Yang, W.; Li, Y.; Chen, X.; Lutkenhaus, J.; Huang, S.-Y.; Yang, X.; Du, S.
10.1101/2024.12.31.629942 — microbiology — Posted on 2025-01-01
5202 Nurr1 orchestrates claustrum development and functionality
Yan, K.; Newman, A. G.; Lange, P.; Mueller, S.; Marco Foddis, M.; Mantwill, M.; Finke, C.; Koch, S. P.; Boehm-Sturm, P.; Deng, P.; Long, M.; Tarabykin, V.
10.1101/2024.12.31.630879 — neuroscience — Posted on 2025-01-01
5205 Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology
Rodriguez-Rodriguez, P.; Wang, W.; Tsagkogianni, C.; Feng, I.; Morello-Megias, A.; Jain, K.; Alanko, V.; Kahvecioglu, H.; Mohammadi, E.; Li, X.; Flajolet, M.; Sandebring-Matton, A.; Maioli, S.; Vidal, N.; Milosevic, A.; Roussarie, J.-P.
10.1101/2024.12.31.630881 — neuroscience — Posted on 2025-01-01
5206 Different mechanisms link gain and loss of kinesin functions to axonal degeneration
Liew, Y.-T.; Voelzmann, A.; Owens, M.; Day, M.; Cairns, W.; Jones, E.; Dajas-Bailador, F.; McCann, S.; Murphy, T.; Tortoishell, H.; Parkin, J.; Bailey, D. M. D.; Landgraf, M.; Prokop, A.
10.1101/2024.12.31.630930 — neuroscience — Posted on 2025-01-01
5208 Detection of HTTex1p by western blot and immunostaining of HD human and mouse brain using neo-epitope antibody P90 highlights impact of CAG repeat expansion on its size, solubility, and response to MSH3 silencing
Sapp, E.; Boudi, A.; Iwanowicz, A.; Belgrad, J.; Miller, R.; O'Reilly, D.; Yamada, K.; Deng, Y.; Joni, M.; Li, X.; Kegel-Gleason, K.; Khvorova, A.; Reiner, A.; Aronin, N.; DiFiglia, M.
10.1101/2024.12.31.630891 — neuroscience — Posted on 2025-01-01
5209 Circuit dynamics of approach-avoidance conflict in humans
Staveland, B. R.; Oberschulte, J.; Kim-McManus, O.; Willie, J. T.; Brunner, P.; Dastjerdi, M.; Lin, J. J.; Hsu, M.; Knight, R. T.
10.1101/2024.12.31.630927 — neuroscience — Posted on 2025-01-01
5211 YX0798 Is a Highly Potent, Selective, and Orally Effective CDK9 Inhibitor for Treating Aggressive Lymphoma
Jiang, V.; Xue, Y.; Kim, H.; Cai, Q.; Zhang, T.; Nie, L.; McIntosh, J.; Liu, Y.; Chen, H.; Zhou, J.; Wang, M.
10.1101/2024.12.31.629756 — cancer biology — Posted on 2025-01-01