bioRxiv directory

Feng, R.; Tong, C.; Lin, T.; Liu, H.; Shao, C.; Li, Y.; Sticht, C.; Kan, K.; Li, X.; Liu, R.; Wang, S.; Wang, S.; Munker, S.; Niess, H.; Meyer, C.; Liebe, R.; Ebert, M. P.; Dooley, S.; Wang, H.; Ding, H.; Weng, H.-L.

10.1101/2023.01.12.523351 — cell biology — Posted on 2023-01-31

12 Disease diagnostics using machine learning of immune receptors

Zaslavsky, M. E.; Craig, E.; Michuda, J. K.; Ram-Mohan, N.; Lee, J.-Y.; Nguyen, K. D.; Hoh, R. A.; Pham, T. D.; Parsons, E. S.; Macwana, S. R.; DeJager, W.; Roskin, K. M.; Cunningham-Rundles, C.; Moody, M. A.; Haynes, B. F.; Goldman, J. D.; Heath, J. R.; Balboni, I.; Utz, P. J.; Nadeau, K. C.; Pinsky, B. A.; Blish, C. A.; Merrill, J. T.; Guthridge, J. M.; James, J. A.; Yang, S.; Tibshirani, R.; Kundaje, A.; Boyd, S. D.

10.1101/2022.04.26.489314 — immunology — Posted on 2023-01-31

13 Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome

Yan, T.; Julio, A. R.; Villanueva, M.; Jones, A. E.; Ball, A. B.; Boatner, L. M.; Turmon, A. C.; Yen, S. L.; Desai, H. S.; Divakaruni, A. S.; Backus, K. M.

10.1101/2023.01.22.525042 — biochemistry — Posted on 2023-01-31

14 Large haploblocks underlie rapid adaptation in an invasive weed

Battlay, P.; Wilson, J.; Bieker, V. C.; Lee, C.; Prapas, D.; Petersen, B.; Craig, S.; van Boheemen, L.; Scalone, R.; de Silva, N. P.; Sharma, A.; Konstantinovic, B.; Nurkowski, K. A.; Rieseberg, L. H.; Connallon, T.; Martin, M. D.; Hodgins, K. A.

10.1101/2022.03.02.482376 — evolutionary biology — Posted on 2023-01-31

15 Hypermetabolism in mice carrying a near complete human chromosome 21

Sarver, D. C.; Xu, C.; Rodriguez, S.; Aja, S.; Jaffe, A. E.; Gao, F. J.; Delannoy, M.; Periasamy, M.; Kazuki, Y.; Oshimura, M.; Reeves, R. H.; Wong, G. W.

10.1101/2023.01.30.526183 — physiology — Posted on 2023-01-31

16 Uncovering the Consequences of Batch-Effect Associated Missing Values in Omics Data Analysis

Hui, H. W. H.; Goh, W. W. B.

10.1101/2023.01.30.526187 — bioinformatics — Posted on 2023-01-31

17 The C9Orf72 hexanucleotide repeat expansion transcript forms insoluble aggregates facilitated by multimolecular G-quadruplex structures

Raguseo, F.; Tanase, D.; Malouf, L.; Rubio Sanchez, R.; Elani, Y.; Di Michele, L.; Di Antonio, M.

10.1101/2023.01.31.526399 — biochemistry — Posted on 2023-01-31

18 Bacterial microbiota of Ostreobium, the coral-isolated chlorophyte ectosymbiont, at contrasted salinities

Masse, A.; Detang, J.; Duval, C.; Duperron, S.; Woo, A.; Domart-Coulon, I.

10.1101/2023.01.31.526156 — genetics — Posted on 2023-01-31

19 Identification of genes associated with abiotic stress tolerance in sweetpotato using weighted gene co-expression network analysis

Kitavi, M. N.; Gemenet, D. C.; Wood, J.; Hamilton, J.; Wu, S.; Fei, Z. C.; Khan, A.; Buell, C. R.

10.1101/2023.01.30.526063 — molecular biology — Posted on 2023-01-31

20 Pan-Cancer Biomarker miR-151a Regulates p21 Partially Through p53

Kurata, J. S.; Lin, R.-J.

10.1101/2023.01.30.526369 — molecular biology — Posted on 2023-01-31

21 Cross-domain interactions induce community stability to benthic biofilms in proglacial streams

Busi, S. B.; Peter, H.; Brandani, J.; Kohler, T. J.; Fodelianakis, S.; Pramateftaki, P.; Bourquin, M.; Ezzat, L.; Michoud, G.; Lane, S.; Wilmes, P.; Battin, T.

10.1101/2023.01.31.526486 — microbiology — Posted on 2023-01-31

22 Rewiring of the host cell metabolome and lipidome during lytic gammaherpesvirus infection is essential for infectious virus production

Clark, S. A.; Vazquez, A.; Furiya, K.; Splattstoesser, M. K.; Bashmail, A. K.; Schwartz, H.; Russell, M.; Bhark, S.-J.; Moreno, O. K.; McGovern, M.; Owsley, E. R.; Nelson, T. A.; Sanchez, E.; Delgado, T.

10.1101/2023.01.30.526357 — microbiology — Posted on 2023-01-31

23 Brain signatures indexing variation in internal processing during perceptual decision-making

Nakuci, J.; Samaha, J.; Rahnev, D.

10.1101/2023.01.10.523502 — neuroscience — Posted on 2023-01-31

24 Protracted morphine withdrawal corresponds with sex-specific alterations to motivated behavior and mesoaccumbal subcircuit dopamine cell plasticity

Gomez, D. M.; Kahl, T.; Brettingen, E.; Hearing, M.

10.1101/2023.01.29.526129 — neuroscience — Posted on 2023-01-31

25 Dissecting errors made in response to externally- and internally- driven visual tasks in the common marmosets and humans

Amly, W.; Chen, C.-Y.; Onoe, H.; Isa, T.

10.1101/2021.08.29.458139 — neuroscience — Posted on 2023-01-31

26 The post-translational modification profile of TAR DNA-Binding Protein (TDP-43) in platelets of patients with Alzheimer's disease: An exploratory study for blood-based biomarker development.

Johnson, Q.; Hadjian, M.; Bah, A.; Smith, S.; Kosa, E.; Agbas, A.

10.1101/2023.01.29.526122 — neuroscience — Posted on 2023-01-31

27 Functional Trajectories after Zebrafish Spinal Cord Transection

Jensen, N. O.; Burris, B.; Zhou, L.; Yamada, H.; Reyes, C.; Mokalled, M. H.

10.1101/2023.01.31.526502 — neuroscience — Posted on 2023-01-31

28 Biochemical and Genetic Evidence Supports Fyv6 as a Second-Step Splicing Factor in Saccharomyces cerevisiae

Lipinski, K. A.; Senn, K. A.; Zeps, N. J.; Hoskins, A. A.

10.1101/2023.01.30.526368 — biochemistry — Posted on 2023-01-31

29 A general strategy to develop fluorogenic polymethine dyes for bioimaging

Martin, A.; Rivera-Fuentes, P.

10.1101/2023.01.31.526423 — biochemistry — Posted on 2023-01-31

30 Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif

Brkic, A.; Leibundgut, M.; Jablonska, J.; Zanki, V.; Car, Z.; Petrovic-Perokovic, V.; Marsavelski, A.; Ban, N.; Gruic-Sovulj, I.

10.1101/2023.01.31.526100 — biochemistry — Posted on 2023-01-31

31 Genomic evidence for West Antarctic Ice Sheet collapse during the Last Interglacial Period

Lau, S. C. Y.; Wilson, N. G.; Golledge, N. R.; Naish, T. R.; Watts, P. C.; Silva, C. N. S.; Cooke, I. R.; Allcock, A. L.; Mark, F. C.; Linse, K.; Strugnell, J. M.

10.1101/2023.01.29.525778 — evolutionary biology — Posted on 2023-01-31

32 Homocysteine accelerates hepatocyte autophagy by upregulation of TFEB via DNMT3b-mediated DNA hypomethylation

Yang, A.; Zeng, W.; Hao, Y.; Zhang, H.; Wang, Q.; Sun, Y.; Quan, S.; Ding, N.; Yang, X.; Sun, J.; Zhang, H.; Liu, B.; Jiao, Y.; Wu, K.; Jiang, Y.

10.1101/2023.01.30.526165 — cell biology — Posted on 2023-01-31

33 A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

Maher, S. P.; Bakowski, M. A.; Vantaux, A.; Flannery, E. L.; Andolina, C.; Gupta, M.; Antonova-Koch, Y.; Argomaniz, M.; Monica, C.-M.; Brice, C.; Chao, A. T.; Chatterjee, A. K.; Cheng, W. T.; Cooper, C. A.; Karissa, C.; Galinski, M. R.; Harupa-Chung, A.; Ji, H.; Joseph, S. B.; Lenz, T.; Lonardi, S.; Matheson, J.; Mikolajczak, S. A.; Padin-Irizarry, V.; Pan, K.; Peneau, J.; Prudhomme, J.; Roesch, C.; Sabnis, S. S.; Saney, C. L.; Sattabongkot, J.; Sereshki, S.; Suriyakan, S.; Timothy, M.; Ubalee, R.; Wang, Y.; Wasisakun, P.; Yin, J.; McNamara, C. W.; Joyner, C. J.; Nosten, F.; Witkowski, B.; Le

10.1101/2023.01.31.526483 — cell biology — Posted on 2023-01-31

34 NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains

Huynh, O.; Ruis, K.; Montales, K.; Michael, W. M.

10.1101/2022.09.26.509489 — cell biology — Posted on 2023-01-31

35 Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43, drive ribonucleoprotein condensate transport dysfunction and suppress local translation

Wijegunawardana, D.; Vishal, S. S.; Venkatesh, N.; Gopal, P. P.

10.1101/2023.01.30.526372 — cell biology — Posted on 2023-01-31

36 Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control

Gurzeler, L.-A.; Link, M.; Ibig, Y.; Schmidt, I.; Galuba, O.; Schoenbett, J.; Gasser-Didierlaurant, C.; Parker, C. N.; Mao, X.; Bitsch, F.; Schirle, M.; Couttet, P.; Sigoillot, F.; Ziegelmuller, J.; Uldry, A.-C.; Schmiedeberg, N.; Muhlemann, O.; Reinhardt, J.

10.1101/2023.01.31.526456 — molecular biology — Posted on 2023-01-31

37 The viral packaging motor potentiates late gene expression in Kaposi's sarcoma-associated herpesvirus

McCollum, C. O.; Didychuk, A. L.; Liu, D.; Murray-Nerger, L. A.; Christea, I. M.; Glaunsinger, B. A.

10.1101/2023.01.29.526158 — molecular biology — Posted on 2023-01-31

38 Detection and quantification of the histone code in the fungal genus Aspergillus

Zhang, X.; Noberini, R.; Vai, A.; Bonaldi, T.; Seidl, M. F.; Collemare, J.

10.1101/2023.01.31.526455 — molecular biology — Posted on 2023-01-31

39 CRISPR/Cas12a toolbox for genomic manipulation in Methanosarcina acetivorans

Zhu, P.; Bao, J.; Scheller, S.

10.1101/2023.01.31.526428 — molecular biology — Posted on 2023-01-31

40 Invasive Californian death caps develop mushrooms unisexually and bisexually

Wang, Y.-W.; McKeon, M. C.; Elmore, H.; Hess, J.; Golan, J.; Gage, H.; Mao, W.; Harrow, L.; Goncalves, S. C.; Hull, C. M.; Pringle, A.

10.1101/2023.01.30.525609 — microbiology — Posted on 2023-01-31

41 Being spontaneous has its costs! Characterization of the spontaneous phage ΦD5-resistant mutants of Dickeya solani strain IPO 2222

Sokolova, D.; Smolarska, A.; Bartnik, P.; Rabalski, L.; Kosinski, M.; Narajczyk, M.; Krzyzanowska, D.; Rajewska, M.; Mruk, I.; Czaplewska, P.; Jafra, S. J.; Czajkowski, R.

10.1101/2023.01.31.526416 — microbiology — Posted on 2023-01-31

42 Antiviral action of aqueous extracts of propolis from Scaptotrigona aff. postica against Zica, Chikungunya, and Mayaro virus

Mendonca, R. Z.; Nascimento, R. M.; Fernandes, A. C. O.; Silva Junior, P. I.

10.1101/2022.11.03.515030 — microbiology — Posted on 2023-01-31

43 Simultaneous 3D Cellular Positioning and Apical Dendritic Morphology of Transgenic Fluorescent Mouse CA3 Hippocampal Pyramidal Neurons

Handwerk, C. J.; Bland, K. M.; Denzler, C. J.; Kalinowski, A. R.; Brett, C. A.; Swinehart, B. D.; Rodriguez, H. V.; Cook, H. N.; Vinson, E. C.; Florenz, M. E.; Vidal, G. S.

10.1101/2022.08.12.503761 — neuroscience — Posted on 2023-01-31

44 Heterogeneous Receptor Expression UnderliesNon-uniform Peptidergic Modulation ofOlfaction in Drosophila

Sizemore, T. R.; Jonaitis, J.; Dacks, A. M.

10.1101/2022.04.27.489804 — neuroscience — Posted on 2023-01-31

45 No evidence for differences in contrast of the grey-white matter boundary in Autism Spectrum Disorders: An open replication

Traut, N.; Fouquet, M.; Delorme, R.; Bourgeron, T.; Beggiato, A.; Toro, R.

10.1101/750117 — neuroscience — Posted on 2023-01-31

46 Exploring the host range for genetic transfer of magnetic organelle biosynthesis

Dziuba, M. V.; Mueller, F. D.; Posfai, M.; Schueler, D.

10.1101/2023.01.31.526216 — synthetic biology — Posted on 2023-01-31

47 A modular plasmid toolkit applied in marine Proteobacteria reveals functional insights during bacteria-stimulated metamorphosis

Alker, A. T.; Aspiras, A. E.; Dunbar, T. L.; Farrell, M. V.; Fedoriouk, A.; Jones, J. E.; Mikhail, S. R.; Salcedo, G. Y.; Moore, B. S.; Shikuma, N. J.

10.1101/2023.01.31.526474 — synthetic biology — Posted on 2023-01-31

48 Two splice forms of OsbZIP1, a homolog of AtHY5, function to regulate skoto- and photo-morphogenesis in rice

Bhatnagar, A.; Burman, N.; Sharma, E.; Tyagi, A. K.; Khurana, P.; Khurana, J. P.

10.1101/2023.01.30.526072 — plant biology — Posted on 2023-01-31

49 Molecular and cellular mechanisms by which cardiac sympathetic denervation prevents heart failure and sudden cardiac arrest

DeMazumder, D.; Joshi, P.; O'Rourke, B.; Estes, S.; Dey, S.

10.1101/2023.01.29.526082 — physiology — Posted on 2023-01-31

50 Ryanodine receptor inhibition improves cardiac repolarization reserve and contractile function and prevents sudden arrhythmic death in failing hearts.

Joshi, P.; Estes, S.; DeMazumder, D.; Knollmann, B. C.; Dey, S.

10.1101/2023.01.29.526151 — physiology — Posted on 2023-01-31

51 Adaptive Ensemble Refinement of Protein Structures in High Resolution Electron Microscopy Density Maps with Flexible Fitting via Ensemble Toolkit

Sarkar, D.; Lee, H.; Vant, J. W.; Turilli, M.; Vermaas, J. V.; Jha, S.; Singharoy, A.

10.1101/2021.12.07.471672 — biophysics — Posted on 2023-01-31

52 Aminobenzoic acid derivatives obstruct induced fit in the catalytic center of the ribosome

Majumdar, C.; Walker, J. A.; Francis, M. B.; Schepartz, A.; Cate, J. H. D.

10.1101/2023.01.25.525534 — biophysics — Posted on 2023-01-31

53 Scalable neighbour search and alignment with uvaia

de Oliveira Martins, L.; Mather, A. E.; Page, A. J.

10.1101/2023.01.31.526458 — bioinformatics — Posted on 2023-01-31

54 Computational prediction of MHC anchor locations guide neoantigen identification and prioritization

Xia, H.; McMichael, J. F.; Becker-Hapak, M.; Onyeador, O. C.; Buchli, R.; McClain, E.; Pence, P.; Supabphol, S.; Richters, M. M.; Basu, A.; Ramirez, C. A.; Puig-Saus, C.; Cotto, K. C.; Freshour, S. L.; Hundal, J.; Kiwala, S.; Goedegebuure, S. P.; Johanns, T. M.; Dunn, G. P.; Ribas, A.; Miller, C. A.; Gillanders, W. E.; Fehniger, T. A.; Griffith, O. L.; Griffith, M.

10.1101/2020.12.08.416271 — bioinformatics — Posted on 2023-01-31

55 MHCnvex: Likelihood-based model for calling the copy number variations and loss of heterozygosity in MHC class I and II locus

Hosseini, N.; Mumphrey, M. B.; Cieslik, M.

10.1101/2023.01.29.526131 — bioinformatics — Posted on 2023-01-31

56 Study on the expression of RAD51 in non-small cell lung cancer based on bioinformatics

WU, J.; ZHANG, X.-Y.; ZHANG, Y.-m.; Gao, F.; WANG, G.-y.

10.1101/2023.01.29.526152 — bioinformatics — Posted on 2023-01-31

57 Differentiable Partition Function Calculation for RNA

Matthies, M.; Krueger, R.; Torda, A.; Ward, M.

10.1101/2023.01.30.526001 — bioinformatics — Posted on 2023-01-31

58 Charge-State-Dependent Collision-Induced Dissociation Behaviors of RNA Oligonucleotides via High-Resolution Mass Spectrometry

Sun, R.; Zuo, M.-Q.; Zhang, J.-S.; Dong, M.-Q.

10.1101/2023.01.29.526146 — bioinformatics — Posted on 2023-01-31

59 Rapid, DNA-induced subunit exchange by DNA gyrase

Germe, T.; Bush, N. G.; Baskerville, V.; Saman, D.; Benesch, J. L.; Maxwell, A.

10.1101/2022.09.08.507137 — biochemistry — Posted on 2023-01-31

60 Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury

Rauckhorst, A.; Martinez, G. V.; Andrade, G. M.; Wen, H.; Kim, J. Y.; Simoni, A.; Mapuskar, K. A.; Rastogi, P.; Steinbach, E. J.; McCormick, M. L.; Allen, B. G.; Jackson, A. R.; Pabla, N. S.; Coleman, M. C.; Spitz, D. R.; Taylor, E. B.; Zepeda-Orozco, D.

10.1101/2023.01.31.526492 — biochemistry — Posted on 2023-01-31

61 Glycoproteomics-compatible MS/MS-based quantification of glycopeptide isomers

Maliepaard, J. C. L.; Damen, J. M. A.; Boons, G.-J. P. H.; Reiding, K. R.

10.1101/2023.01.31.526390 — biochemistry — Posted on 2023-01-31

62 Metagenomic analysis of Pigs' faecal microbiome and its functional response associated with dietary fibre

Barman, K.; Choudhury, M.; Banik, S.; Pegu, S. R.; Kumar, S.; Deb, R.; Rahman, J.; Rajkhowa, S.; Jat, S. L.; Rakshit, S.; Gupta, V. K.; Das, P. J.

10.1101/2023.01.29.526153 — genomics — Posted on 2023-01-31

63 PerturbSci-Kinetics: Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens

Xu, Z.; Sziraki, A.; Lee, J.; Zhou, W.; Cao, J.

10.1101/2023.01.29.526143 — genomics — Posted on 2023-01-31

64 Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants

Einson, J.; Glinos, D.; Boerwinkle, E.; Castaldi, P.; Darbar, D.; de Andrade, M.; Ellinor, P.; Fornage, M.; Gabriel, S.; Germer, S.; Gibbs, R.; Hersh, C.; Johnsen, J.; Kaplan, R.; Konkle, B.; Kooperberg, C.; Nassir, R.; Loos, R. J. F.; Meyers, D. A.; Mitchell, B. D.; Psaty, B.; Vasan, R. S.; Rich, S. S.; Rienstra, M.; Rotter, J. I.; Saferali, A.; Shoemaker, M. B.; Silverman, E.; Smith, A. V.; Mohammadi, P.; Castel, S. E.; Iossifov, I.; Lappalainen, T.

10.1101/2023.01.31.526505 — genetics — Posted on 2023-01-31

65 Mangrove propagules are limited in their capacity to disperse across long distances

Granville, N. R.; Banks-Leite, C.

10.1101/2023.01.30.526169 — ecology — Posted on 2023-01-31

66 The Dietary Fermentable Fiber Inulin Alters the Intestinal Microbiome and Improves Chronic Kidney Disease Mineral-Bone Disorder in a Rat Model of CKD

Moe, S. M.; Biruete, A.; Chen, N. X.; Metzger, C. E.; Srinivasan, S.; O'Neill, K.; Fallen, P.; Fonseca, A. D.; Wilson, H. E.; Evenepoel, P.; Swanson, K. S.; de Loor, H.; Allen, M. A.

10.1101/2023.01.29.526093 — cell biology — Posted on 2023-01-31

67 The conserved AAA-ATPase PCH-2 distributes its regulation of meiotic prophase events by remodeling multiple meiotic HORMADs in C. elegans

Russo, A. E.; Giacopazzi, S.; Deshong, A.; Menon, M.; Ortiz, V. A.; Ego, K. M.; Corbett, K. D.; Bhalla, N.

10.1101/2022.05.31.494220 — cell biology — Posted on 2023-01-31

68 Lateral and longitudinal compaction of PRC1 overlap zones drive stabilization of interzonal microtubules

Fermino do Rosario, C.; Zhang, Y.; Stadnicki, J.; Ross, J. L.; Wadsworth, P.

10.1101/2023.01.30.526324 — cell biology — Posted on 2023-01-31

69 Bei Mu Gua Lou San facilitates mucus expectoration by increasing surface area and hydration levels of airway mucus in an air-liquid-interface cell culture model of the respiratory epithelium

Groiss, S.; Somvilla, I.; Daxboeck, C.; Stueckler, M.; Pritz, E.; Brislinger, D.

10.1101/2023.01.31.526405 — molecular biology — Posted on 2023-01-31

70 Transcriptomic-based selection of reference genes for quantitative real-time PCR in an insect endosymbiotic model

Vallier, A.; Dell'Aglio, E.; Ferrarini, M. G.; Hurtado, O.; Vincent-Monegat, C.; Heddi, A.; Rebollo, R.; Zaidman-Remy, A.

10.1101/2023.01.31.526490 — molecular biology — Posted on 2023-01-31

71 Outcome of Drosophila microbiota manipulation depends on dietary preservative formula and batch variation in dietary yeast

Sannino, D. R.; Dobson, A. J.

10.1101/2023.01.30.526386 — microbiology — Posted on 2023-01-31

72 Three dominant Vibrio cholerae lytic phage all require O1 antigen for infection

Beckman, D. A.; Waters, C. M.

10.1101/2023.01.31.526503 — microbiology — Posted on 2023-01-31

73 Fundamentals of biofilm formation in soil: From functionalized self-assembled monolayers to rewilding

Hendiani, S.; Hansen, M. F.; Kontopoulos, I.; Verma, T.; Pucetaite, M.; Burmolle, M.; Ramstedt, M.; Sand, K. K. S.

10.1101/2023.01.30.526320 — microbiology — Posted on 2023-01-31

74 Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism

Harris, R. S.; Fanunza, E.; Cheng, A.; Auerbach, A.; Stefanovska, B.; Moraes, S. N.; Lokensgard, J.; Biolatti, M.; Dell'Oste, V.; Bierle, C. J.; Bresnahan, W. A.

10.1101/2023.01.30.526383 — microbiology — Posted on 2023-01-31

75 Pseudouridine prevalence in Kaposi's sarcoma associated herpesvirus transcriptome reveals an essential mechanism for viral replication

Mottram, T. J.; Harper, K. L.; Vasconcelos, E. J.; Anene, C. A.; Whitehouse, A.

10.1101/2023.01.31.526461 — microbiology — Posted on 2023-01-31

76 Borrelia burgdorferi PlzA is a c-di-GMP dependent DNA and RNA binding protein

Jusufovic, N.; Savage, C.; Saylor, T. C.; Brissette, C. A.; Zueckert, W. R.; Schlax, P.; MOTALEB, M. A. R.; Stevenson, B.

10.1101/2023.01.30.526351 — microbiology — Posted on 2023-01-31

77 Rickettsiales' deep evolutionary history sheds light on the emergence of intracellular lifestyles

Serra Moncadas, L.; Shabarova, T.; Silva Kavagutti, V.; Bulzu, P.-A.; Chiriac, M.-C.; Park, S.-J.; Mukherjee, I.; Ghai, R.; Andrei, A.-S.

10.1101/2023.01.31.526412 — microbiology — Posted on 2023-01-31

78 Structures of Arabidopsis thaliana MDL Proteins and Synergistic Effects with the Cytokine MIF on Human Receptors

Spiller, L.; Ramu, M.; Leissing, F.; Basquin, J.; Bourilhon, P.; Sinitski, D.; Brandhofer, M.; Levecque, S. C.; Sabelleck, B.; Feederle, R.; Flatley, A.; Panstruga, R.; Bernhagen, J.; Lolis, E.

10.1101/2023.01.30.525655 — immunology — Posted on 2023-01-31

79 MEG frequency tagging reveals a grid-like code during covert attentional movements

Giari, G.; Vignali, L.; Xu, Y.; Bottini, R.

10.1101/2023.01.29.526079 — neuroscience — Posted on 2023-01-31

80 Microglial phagocytosis mediates long-term restructuring of spinal GABAergic circuits following early life injury

Xu, Y.; Moulding, D.; Jin, W.; Beggs, S.

10.1101/2023.01.29.525735 — neuroscience — Posted on 2023-01-31

81 Reduced dimension stimulus decoding and column-based modeling reveal architectural differences of primary somatosensory finger maps between younger and older adults

Kalyani, A.; contier, o.; Klemm, L.; Azanon, E.; Schreiber, S.; Speck, O.; Reichert, C.; Kuehn, E.

10.1101/2023.01.30.526109 — neuroscience — Posted on 2023-01-31

82 Emergence of time persistence in an interpretable data-driven neural network model

Wolf, S.; Le Goc, G.; Cocco, S.; Debregeas, G.; Monasson, R.

10.1101/2022.02.02.478841 — neuroscience — Posted on 2023-01-31

83 Characterization of the bioaccumulation and toxicity of copper pyrithione, an antifouling compound, on juveniles of rainbow trout

Bourdon, C.; Cachot, J.; Gonzalez, P.; Couture, P.

10.1101/2023.01.31.526498 — pharmacology and toxicology — Posted on 2023-01-31

84 TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

Yu, P.; Qu, N.; Zhu, R.; Hu, J.; Han, P.; Tan, L.; Gan, H.; He, C.; Fang, C.; Lei, Y.; Li, J.; He, C.; Lan, F.; Shi, X.; Wei, W.; Wang, Y.; Ji, Q.; Yu, F.-x.; Wang, Y.-l.

10.1101/2023.01.29.526126 — cancer biology — Posted on 2023-01-31

85 Predicting response to cytotoxic chemotherapy

Madrid, L.; Thompson, J.; Vias, M.; Escobar-Rey, M.; Leung, W.-K.; Huckstep, J.; Sekowska, M.; Hosking, K.; Jimenez-Linan, M.; Reinius, M.; Sauer, C.; Dobson, H.; Fernandez-Sanroman, A.; Sanders, D.; Correia Martins, F.; Markowetz, F.; Yip, J.; Brenton, J. D.; Piskorz, A.; Macintyre, G.

10.1101/2023.01.28.525988 — cancer biology — Posted on 2023-01-31

86 On Pre-trained Language Models for Antibody

Wang, D.; Ye, F.; Zhou, H.

10.1101/2023.01.29.525793 — bioinformatics — Posted on 2023-01-31

87 HLAProphet: Personalized allele-level quantification of the HLA proteins

Mumphrey, M. B.; Li, G. X.; Hosseini, N.; Nesvizhskii, A.; Cieslik, M.

10.1101/2023.01.29.526142 — bioinformatics — Posted on 2023-01-31

88 Single-cell multi-omic topic embedding reveals cell-type-specific and COVID-19 severity-related immune signatures

Zhou, M.; Zhang, H.; Bai, Z.; Mann-Krzisnik, D.; Wang, F.; Li, Y.

10.1101/2023.01.31.526312 — bioinformatics — Posted on 2023-01-31

89 Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

Ge, R.; Yu, Y.; Qi, Y. X.; Fan, Y. V.; Chen, S.; Gao, C.; Haas, S. S.; Modabbernia, A.; New, F.; Agartz, I.; Asherson, P.; Ayesa-Arriola, R.; Banaj, N.; Banaschewski, T.; Baumeister, S.; Bertolino, A.; Boomsma, D. I.; Borgwardt, S.; Bourque, J.; Brandeis, D.; Breier, A.; Brodaty, H.; Brouwer, R. M.; Buckner, R.; Buitelaar, J. K.; Cannon, D. M.; Caseras, X.; Cervenka, S.; Conrod, P. J.; Crespo-Facorro, B.; Crivello, F.; Crone, E. A.; de Haan, L.; de Zubicaray, G. I.; Di Giorgio, A.; Erk, S.; Fisher, S. E.; Franke, B.; Frodl, T.; Glahn, D. C.; Grotegerd, D.; Gruber, O.; Gruner, P.; Gur, R. E.; G

10.1101/2023.01.30.523509 — bioinformatics — Posted on 2023-01-31

90 Quantitative Annotations of T-Cell Repertoire Specificity

Luo, J.; Wang, X.; Zou, Y.; Chen, L.; Liu, W.; Zhang, W.; Li, S.

10.1101/2023.01.29.526145 — bioinformatics — Posted on 2023-01-31

91 Privately Owned Plants need Space: An Analysis on Plant Biodiversity in Toronto's Privately-owned Publicly Accessible Spaces

Ho, M. R.

10.1101/2023.01.29.526117 — ecology — Posted on 2023-01-31

92 A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells

Li, L.; Bowling, S.; Yu, Q.; McGeary, S. E.; Alcedo, K.; Lemke, B.; Ferreira, M.; Klein, A. M.; Wang, S.-W.; Camargo, F.

10.1101/2023.01.29.526062 — developmental biology — Posted on 2023-01-31

93 Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization

Jang, K. K.; Heaney, T.; London, M.; Ding, Y.; Yeung, F.; Ercelen, D.; Chen, Y.-H.; Axelrad, J.; Gurunathan, S.; Keestra-Gounde, A. M.; Griffin, M. E.; Hang, H. C.; Cadwell, K.

10.1101/2023.01.29.526128 — immunology — Posted on 2023-01-31

94 Rapid withdrawal from threatening animals is movement-specific and mediated by reflex-like neural processing

Railo, H.; Kraufvelin, N.; Santalahti, J.; Laine, T.

10.1101/2023.01.29.526084 — neuroscience — Posted on 2023-01-31

95 Distribution-modeling quantifies collective Th cell decision circuits in chronic inflammation

Burt, P.; Thurley, K.

10.1101/2023.01.29.526090 — systems biology — Posted on 2023-01-31

96 Host-microbe interactions mediate doramectin-promoted metabolic reprogramming of CD8+ T-cells and amplify antitumor immunity

Taghinezhad-S, S.; Mohseni, A. H.; Jiang, W.; Casolaro, V.; G. Bermudez-Humaran, L.; McAllister, F.; Lv, Z.; Li, D.

10.1101/2023.01.29.525543 — cancer biology — Posted on 2023-01-31

97 Organoid generation from mouse mammary tumors captures the genetic heterogeneity of clinically relevant copy number alterations

Lake, K.; Colonetta, M.; Smith, C.; Martinez-Algarin, K.; Saunders, K.; Mohta, S.; Pena, J.; McArthur, H. L.; Reddy, S. M.; Roussos-Torres, E. T.; Chen, E. H.; Chan, I. S.

10.1101/2023.01.29.526141 — cancer biology — Posted on 2023-01-31

98 In Vitro Validation of Computationally Predicted Oncogenic Driver Mutations in EGFR Tyrosine Kinase Domain

Warrier, V. P.; Paruchuri, A.; Ramasamy, S.; Gromiha, M. M.; Karunagaran, D.

10.1101/2023.01.29.526080 — cancer biology — Posted on 2023-01-31

99 In Silico Evaluation of Biomarker Genes for Melanoma Carcinoma

Kwatra, B. B.; Khan, M. M.

10.1101/2023.01.29.526121 — cancer biology — Posted on 2023-01-31

100 Crafting negative training datasets for a high-performance classification of bacterial proteins secreted via non-classical pathways

Oliveira, L. G.; Lanes, G. C.; Santos, A. R. d.

10.1101/2023.01.29.526081 — bioinformatics — Posted on 2023-01-31

101 Data-driven optimization of biomarker panels in highly multiplexed imaging

Sun, H.; Li, J.; Murphy, R. F.

10.1101/2023.01.29.526114 — bioinformatics — Posted on 2023-01-31

102 Single-cell RNA sequencing reveals dysregulated fibroblast subclusters in prurigo nodularis

Patel, J. R.; Joel, M. Z.; Lee, K. K.; Kambala, A.; Cornman, H.; Oladipo, O.; Taylor, M.; Deng, J.; Parthasarathy, V.; Cravero, K.; Marani, M.; Zhao, R.; Sankararam, S.; Li, R.; Pritchard, T.; Rebecca, V.; Kwatra, M. M.; Dong, X.; Kang, S.; Kwatra, S. G.

10.1101/2023.01.29.526050 — bioinformatics — Posted on 2023-01-31

103 Optimizing the design of spatial genomic studies

Jones, A.; Cai, D.; Li, D.; Engelhardt, B. E.

10.1101/2023.01.29.526115 — bioinformatics — Posted on 2023-01-31

104 Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues

Lee, P.-Y.; Schilpp, H.; Naylor, N.; Watkins, S. C.; Yang, B.; Sigal, I. A.

10.1101/2023.01.29.526111 — bioengineering — Posted on 2023-01-31

105 In vivo Modulation of Intraocular and Intracranial Pressures Causes Nonlinear and Non-monotonic Deformations of the Lamina Cribrosa and Scleral Canal

Zhu, Z.; Waxman, S.; Wang, B.; Wallace, J.; Schmitt, S. E.; Tyler-Kabara, E.; Ishikawa, H.; Schuman, J. S.; Smith, M. A.; Wollstein, G.; Sigal, I. A.

10.1101/2023.01.29.526113 — bioengineering — Posted on 2023-01-31

106 Range-wide differential adaptation and genomic vulnerability in critically endangered Asian rosewoods

Hung, T. H.; So, T.; Thammavong, B.; Chamchumroon, V.; Theilade, I.; Phourin, C.; Bouamanivong, S.; Hartvig, I.; Gaisberger, H.; Jalonen, R.; Boshier, D. H.; MacKay, J. J.

10.1101/2023.01.29.524750 — genomics — Posted on 2023-01-31

107 Microevolution and phylogenomic characterization with perspectives in the 2022-2023 outbreak of child Respiratory Syncytial Virus type A

Majaz, S.; Ahmad, A.; Saeed, A.; Noreen, S.; Nouroz, F.; Xie, Y.; Amin, A.

10.1101/2023.01.28.526017 — evolutionary biology — Posted on 2023-01-31

108 Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation, and chromosome segregation of sexual transmission stages

Zeeshan, M.; Rea, E.; Abel, S.; Vukusic, K.; Markus, R.; Brady, D.; Eze, A. A.; Rashpa, R.; Balestra, A.; Bottrill, A.; Brochet, M.; Guttery, D.; Tolic, I. M.; Holder, A. A.; Le Roch, K. G.; Tromer, E.; Tewari, R.

10.1101/2023.01.29.526106 — cell biology — Posted on 2023-01-31

109 Extracellular communication between brain cells through functional transfer of Cre mRNA

Rufino-Ramos, D.; Leandro, K.; Perdigao, P.; O'Brien, K.; Pinto, M.; Santana, M.; SOLINGE, T.; Mahjoum, S.; Breakefield, X.; Breyne, K.; Pereira de Almeida, L.

10.1101/2023.01.29.525937 — cell biology — Posted on 2023-01-31

110 A comprehensive survey of coronaviral main protease active site diversity in 3D: Identifying and analyzing drug discovery targets in search of broad specificity inhibitors for the next coronavirus pandemic

Lubin, J. H.; Martinusen, S. G.; Zardecki, C.; Olivas, C.; Bacorn, M.; Balogun, M.; Slaton, E. W.; Wu, A. W.; Sakeer, S.; Hudson, B. P.; Denard, C.; Burley, S. K.; Khare, S. D.

10.1101/2023.01.30.526101 — molecular biology — Posted on 2023-01-31

111 A Novel Explainable Fuzzy Clustering Approach for fMRI Dynamic Functional Network Connectivity Analysis

Ellis, C. A.; Miller, R. L.; Calhoun, V. D.

10.1101/2023.01.29.526110 — neuroscience — Posted on 2023-01-31

112 Modulation of perception by visual, auditory, and audiovisual reward predicting cues

Antono, J. E.; Pooresmaeili, A.

10.1101/2023.01.29.526087 — neuroscience — Posted on 2023-01-31

113 Long-range alteration of the physical environment mediates cooperation between Pseudomonas aeruginosa swarming colonies

Deforet, M.

10.1101/2022.06.29.498166 — systems biology — Posted on 2023-01-31

114 EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

Chakraborty, S.; Bhat, A. M.; Mushtaq, I.; Luan, H.; Kalluchi, A.; Mirza, S.; Storck, M. D.; Chaturvedi, N.; Lopez-Guerrero, J. A.; Llombart-Bosch, A.; Machado, I.; Scotlandi, K.; Meza, J. L.; Ghosal, G.; Coulter, D. W.; Rowley, J. M.; Band, V.; Mohapatra, B. C.; Band, H.

10.1101/2023.01.15.524130 — cancer biology — Posted on 2023-01-31

115 Fitness effects of mutations to SARS-CoV-2 proteins

Bloom, J. D.; Neher, R. A.

10.1101/2023.01.30.526314 — evolutionary biology — Posted on 2023-01-31

116 Impact of different mutations on Kelch13 protein levels, ART resistance and fitness cost in Plasmodium falciparum parasites

Behrens, H. M.; Schmidt, S.; Peigney, D.; Sabitzki, R.; Henshall, I.; May, J.; Maïga-Ascofare, O.; Spielmann, T.

10.1101/2022.05.13.491767 — microbiology — Posted on 2023-01-31

117 Spontaneous rotations in epithelia as an interplay between cell polarity and boundaries.

Lo Vecchio, S.; Pertz, O.; Szopos, M.; Navoret, L.; Riveline, D.

10.1101/2021.11.11.468187 — biophysics — Posted on 2023-01-31

118 High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display

Li, A.; Voleti, R.; Lee, M.; Gagoski, D.; Shah, N. H.

10.1101/2022.08.01.502334 — biochemistry — Posted on 2023-01-31

119 Adaptation of a quantitative trait to a changing environment: new analytical insights on the asexual and infinitesimal sexual models.

Garnier, J.; Cotto, O.; Bourgeron, T.; Bouin, E.; Lepoutre, T.; Ronce, O.; Calvez, V.

10.1101/2022.06.22.497192 — evolutionary biology — Posted on 2023-01-31

120 Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion.

Ni, D.; Lau, K.; Turelli, P.; Raclot, C.; Beckert, B.; Nazarov, S.; Pojer, F.; Myasnikov, A.; Stahlberg, H.; Trono, D.

10.1101/2021.12.27.474250 — immunology — Posted on 2023-01-31

121 Pinging the brain to reveal the hidden attentional priority map using encephalography

Duncan, D. H.; van Moorselaar, D.; Theeuwes, J.

10.1101/2022.08.23.504931 — neuroscience — Posted on 2023-01-31

122 Metabolic responses of normal rat kidneys to a high salt intake.

Shimada, S.; Hoffmann, B. R.; Yang, C.; Kurth, T.; Greene, A. S.; Liang, M.; Dash, R. K.; Cowley, A. W.

10.1101/2023.01.18.524636 — physiology — Posted on 2023-01-31

123 Trabecular bone remodeling in the ageing mouse: a micro-multiphysics agent-based in silico model using single-cell mechanomics

Boaretti, D.; Marques, F. C.; Ledoux, C.; Singh, A.; Kendall, J. J.; Wehrle, E.; Kuhn, G. A.; Bansod, Y. D.; Schulte, F.; Müller, R.

10.1101/2022.11.16.516723 — bioengineering — Posted on 2023-01-31

124 A simple, flexible and high-efficiency western blot analysis for age-related human induced neurons

Shen, Y.-F.; Liu, M.-J.; Long, Z.; Shi, X.; Liu, M.-L.

10.1101/2023.01.30.526150 — biochemistry — Posted on 2023-01-31

125 Th1 cells alter the inflammatory signature of IL-6 by channelingSTAT transcription factors to Alu-like retroelements

Millrine, D.; Cardus Figueras, A.; Uceda Fernandez, J.; Andrews, R.; Szomolay, B.; Cossins, B. C.; Rice, C.; Li, J.; Tyrrell, V.; mcLeod, L.; Holmans, P.; O'Donnell, V.; Taylor, P.; Turner, S. J.; Jenkins, B. J.; Jones, G. W.; Topley, N.; Williams, N. M.; Jones, S. A.

10.1101/2022.07.18.499157 — immunology — Posted on 2023-01-31

126 Ketamine selectively changes outcome valuation in a biased matching pennies task

Oemisch, M.; Seo, H.

10.1101/2022.07.25.501468 — neuroscience — Posted on 2023-01-31

127 Dopamine receptor 1 on CaMKII-positive neurons within claustrum mediates adolescent cocaine exposure-induced anxiety and electro-acupuncture therapy

Chen, L.; Liu, Z.; Zhao, Z.; Du, D.; Pan, W.; Wei, X.; Nie, J.; Ge, F.; Ding, J.; Fan, Y.; Kim, H. Y.; Guan, X.

10.1101/2022.10.18.512685 — neuroscience — Posted on 2023-01-31

128 Adult ticks (Ixodes scapularis) infected with B. burgdorferi) have increased overwintering survival, with implications for tick population growth

El Nabbout, A.; Ferguson, L.; Miyashita, A.; Adamo, S. A.

10.1101/2022.12.07.519462 — zoology — Posted on 2023-01-31

129 Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death.

Woodley, K.; Dillingh, L. S.; Giotopoulos, G.; Madrigal, P.; Rattigan, K. M.; Philippe, C.; Dembitz, V.; Magee, A. S. M.; Asby, R.; van de Lagemaat, L. N.; Mappereley, C.; James, S. C.; Prehn, J. H.; Tzelepis, K.; Rouault-Pierre, K.; Vassiliou, G. S.; Kranc, K. R.; Helgason, G.; Huntly, B. J. P.; Gallipoli, P.

10.1101/2022.05.16.492042 — cancer biology — Posted on 2023-01-31

130 DIVE: a reference-free statistical approach to diversity-generating and mobile genetic element discovery

Abante, J.; Wang, P. L.; Salzman, J.

10.1101/2022.06.13.495703 — bioinformatics — Posted on 2023-01-31

131 Head-to-tail peptide cyclization: new directions and application to urotensin II and Nrf2

Karami, Y.; Murail, S.; Giribaldi, J.; Lefranc, B.; Defontaine, F.; Lesouhaitier, O.; Leprince, J.; de Vries, S.; Tuffery, P.

10.1101/2022.01.05.475045 — bioinformatics — Posted on 2023-01-31

132 Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Ni, D.; Turelli, P.; Raclot, C.; Beckert, B.; Nazarov, S.; Pojer, F.; Myasnikov, A.; Trono, D.; Stahlberg, H.; Lau, K.

10.1101/2021.12.27.474250 — immunology — Posted on 2023-01-31

133 SARS-CoV-2 spike RBD and nucleocapsid encoding DNA vaccine elicits T cell and neutralising antibody responses that cross react with variants

Brentville, V. A.; Vankemmelbeke, M.; Methingham, R. L.; Symonds, P.; Cook, K. W.; Urbanowicz, R. A.; Tsoleridis, T.; Coleman, C. M.; Chang, K.-C.; Skinner, A.; Dubinina, E.; Daniels, I.; Shah, S.; Argonza, M.; Delgado, J.; Dwivedi, V.; Kulkarni, V.; Dixon, J. E.; Pockley, A. G.; Adams, S. E.; Paston, S. J.; Daly, J. M.; Ball, J. K.; Durrant, L. G.

10.1101/2021.06.18.448932 — immunology — Posted on 2023-01-31

134 Salience-based information integration: An overarching function of the "social brain"?

Lugrin, C.; Konovalov, A.; Ruff, C. C.

10.1101/2023.01.30.525877 — neuroscience — Posted on 2023-01-31

135 Single-trial dynamics of competing reach plans in the human motor periphery

Selen, L. P. J.; Corneil, B. D.; Medendorp, P. W.

10.1101/765180 — neuroscience — Posted on 2023-01-31

136 SARS-CoV-2 Omicron XBB.1.5 May Be a Variant That Spreads More Widely and Faster Than Other Variants

Sugano, A.; Kataguchi, H.; Ohta, M.; Someya, Y.; Kimura, S.; Maniwa, Y.; Tabata, T.; Takaoka, Y.

10.1101/2023.01.18.524660 — bioinformatics — Posted on 2023-01-31

137 Torsion angles to map and visualize the conformational space of a protein

Ginn, H. M.

10.1101/2022.08.04.502807 — biochemistry — Posted on 2023-01-31

138 Sex differences, asymmetry and age-related white matter development in infants and 5-year-olds as assessed with Tract-Based Spatial Statistics

Kumpulainen, V.; Merisaari, H.; Silver, E.; Copeland, A.; Pulli, E.; Lewis, J. D.; Saukko, E.; Shulist, S. J.; Saunavaara, J.; Parkkola, R.; Lähdesmäki, T.; Karlsson, L.; Karlsson, H.; Tuulari, J. J.

10.1101/2023.01.29.526138 — neuroscience — Posted on 2023-01-31

139 Selective deletion of Methyl CpG binding protein 2 from parvalbumin interneurons in the auditory cortex delays the onset of maternal retrieval in mice

Rupert, D. D.; Pagliaro, A. H.; Choe, J.; Shea, S. D.

10.1101/2023.01.30.526321 — neuroscience — Posted on 2023-01-31

140 Distinct tumor architectures for metastatic colonization of the brain

Gan, S.; Macalinao, D. G.; Shahoei, S. H.; Tian, L.; Jin, X.; Basnet, H.; Muller, J. T.; Atri, P.; Seffar, E.; Chatila, W.; Hadjantonakis, A.-K.; Schultz, N.; Brogi, E.; Bale, T. A.; Pe'er, D.; Massague, J.

10.1101/2023.01.27.525190 — cancer biology — Posted on 2023-01-31

141 Real-Time Quantification of Cell Mechanics and Functions by Double Resonator Piezoelectric Cytometry -Theory and Study of Cellular Adhesion of HUVECs

Zhou, T.; Huang, J.; Xiong, L.; Shen, H.; Huang, F.; Li, W.; Peng, H.; Su, Z.; Pan, W.; Zhao, J.; Zhou, Z.; Bao, D.; Deng, L.

10.1101/2023.01.27.522341 — biophysics — Posted on 2023-01-31

142 Ultra-Fast Bioorthogonal Spin-Labeling and Distance Measurements in Mammalian Cells Using Small, Genetically Encoded Tetrazine Amino Acids

Jana, S.; Evans, E. G. B.; Jang, H. S.; Zhang, S.; Zhang, H.; Rajca, A.; Gordon, S. E.; Zagotta, W. N.; Stoll, S.; Mehl, R. A.

10.1101/2023.01.26.525763 — biochemistry — Posted on 2023-01-31

143 Co-evolutionary patterns shown in Ostreococcus-virus system from the Western Baltic Sea in freshly isolated hosts and viruses.

Listmann, L.; Peters, C.; Rahlff, J.; Esser, S. P.; Schaum, E.

10.1101/2023.01.30.526186 — microbiology — Posted on 2023-01-31

144 Assessing the impact of successive soil cultivation on Meloidogyne enterolobii infection and on soil bacterial assemblages

Pasche, J. M.; Brito, J. A.; Vallat, G.; Brawner, J. T.; Snyder, S. L.; Fleming, E.; Yang, J.; Terra, W. C.; Martins, S. J.

10.1101/2023.01.27.525929 — plant biology — Posted on 2023-01-31

145 Technical insights into fluorescence lifetime microscopy of mechanosensitive Flipper probes

Roffay, C.; Garcia Arcos, J. M.; Chapuis, P.; Lopez-Andarias, J.; Schneider, F.; Colom, A.; Tomba, C.; Di Meglio, I.; Dunsing, V.; Matile, S.; Roux, A.; Mercier, V.

10.1101/2022.09.28.509885 — biophysics — Posted on 2023-01-31

146 A novel platform of RNA 2'-O-methylation high-throughput and site-specific quantification tools revealed its broad distribution on mRNA

Tang, Y.; Wu, Y.; Wang, S.; Lu, X.; Gu, X.; Li, Y.; Yang, F.; Xu, R.; Wang, T.; Jiao, Z.; Wu, Y.; Liu, L.; Chen, J.-Q.; Wang, Q.; Chen, Q.

10.1101/2020.03.27.011759 — genetics — Posted on 2023-01-31

147 Simultaneous Knockouts of the Oxytocin and Vasopressin 1b Receptors in Hippocampal CA2 Impair Social Memory

Cymerblit-Sabba, A.; Walsh, C.; Duan, K.-Z.; Song, J.; Holmes, O.; Young, W. S.

10.1101/2023.01.30.526271 — animal behavior and cognition — Posted on 2023-01-31

148 Humans, rats and mice show species-specific adaptations to sensory statistics in categorisation behaviour

Pedrosa, V.; Menichini, E.; Pajot-moric, Q.; Vincent, P.; Teachen, L.; Zhou, L.; Latham, P.; Akrami, A.

10.1101/2023.01.30.526119 — animal behavior and cognition — Posted on 2023-01-31

149 The evolutionary fate of divergent genomes in hybrid zones between selfing and outcrossing species

Fyon, F.; M. Berbel-Filho, W.

10.1101/2022.12.12.520111 — evolutionary biology — Posted on 2023-01-30

150 Spatial enhancer activation determines inhibitory neuron identity

Dvoretskova, E.; Ho, M. C.; Kittker, V.; Vitali, I.; Lam, D. D.; Delgado, I.; Feng, C.; Torres, M.; Winkelmann, J.; Mayer, C.

10.1101/2023.01.30.525356 — developmental biology — Posted on 2023-01-30

151 USP8 inhibition promotes Parkin-independent mitophagy in the Drosophila brain and in human neurons

Mauri, S.; Bernardo, G.; Martinez, A.; Favaro, M.; Trevisan, M.; Cobraiville, G.; Fillet, M.; Caicci, F.; Whitworth, A. J.; Ziviani, E.

10.1101/2023.01.30.526170 — cell biology — Posted on 2023-01-31

152 Left-hemisphere cortical language regions respond equally to dialogue and monologue

Olson, H. A.; Chen, E. M.-Y.; Lydic, K.; Saxe, R.

10.1101/2023.01.30.526344 — neuroscience — Posted on 2023-01-30

153 LTK and ALK regulate neuronal polarity and cortical migration by modulating IGF1R activity

Attisano, L.; Christova, T.; Ho, S. K. Y.; Liu, Y.; Gill, M.

10.1101/2023.01.29.526107 — neuroscience — Posted on 2023-01-31

154 Unlinked background selection reduces neutral diversity more than linked background selection

Matheson, J. D.; Masel, J.

10.1101/2022.01.11.475913 — evolutionary biology — Posted on 2023-01-30

155 Meta Learning Improves Robustness and Performance in Machine Learning-Guided Protein Engineering

Minot, M.; Reddy, S. T.

10.1101/2023.01.30.526201 — bioengineering — Posted on 2023-01-30

156 Domestication in dry-cured meat Penicillium fungi: convergent specific phenotypes and horizontal gene transfers without strong genetic subdivision

Lo, Y.-C.; Bruxaux, J.; Rodriguez de la Vega, R. C.; O'Donnell, S.; Snirc, A.; Coton, M.; Le Piver, M.; Le Prieur, S.; Roueyre, D.; Dupont, J.; Houbraken, J.; Debuchy, R.; Ropars, J.; Giraud, T.; Branca, A.

10.1101/2022.03.25.485132 — evolutionary biology — Posted on 2023-01-30

157 Are Maximum Yields sustainable? Effect of intra-annualtime-scales on MSY, stability and resilience.

Ricouard, A.; Lehuta, S.; Mahevas, S.

10.1101/2022.09.26.509503 — ecology — Posted on 2023-01-30

158 YgfB increases β-lactam resistance in Pseudomonas aeruginosa by counteracting AlpA-mediated ampDh3 expression

Eggers, O.; Renschler, F.; Michalek, L. A.; Wackler, N.; Walter, E.; Smollich, F.; Klein, K.; Sonnabend, M.; Egle, V.; Angelov, A.; Engesser, C.; Borisova, M.; Mayer, C.; Schuetz, M.; Bohn, E.

10.1101/2022.07.05.498809 — microbiology — Posted on 2023-01-30

159 Applying joint graph embedding to study Alzheimer's neurodegeneration patterns in volumetric data

He, R.; Tward, D. J.

10.1101/2023.01.11.523671 — neuroscience — Posted on 2023-01-30

160 Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla

Pizzuti, A.; Huber, L.; Gulban, O. F.; Benitez-Andonegui, A.; Peters, J.; Goebel, R.

10.1101/2022.07.29.502034 — neuroscience — Posted on 2023-01-30

161 α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization

Feller, B.; Fallon, A.; Luo, W.; Nguyen, P. T.; Shlaifer, I.; Lee, A. K.; Karkout, S.; Bourgault, S.; Durcan, T. M.; Takahashi, H.

10.1101/2023.01.28.526024 — neuroscience — Posted on 2023-01-30

162 Proliferation drives quorum sensing of microbial products in human macrophage populations

Rajab, N.; Gearing, L. J.; Lyu, R.; Prawer, Y. D. J.; Angel, P. W.; Grimmond, S. M.; Laslett, A. L.; McCarthy, D. J.; Wells, C.

10.1101/2022.05.12.491598 — systems biology — Posted on 2023-01-30

163 Motor and cognitive deficits limit the ability to flexibly modulate spatiotemporal gait features in older adults with mild cognitive impairment

Rosenberg, M. C.; Slusarenko, A.; Cao, K.; McKay, J. L.; Emmery, L.; Kesar, T. M.; Hackney, M. E.

10.1101/2022.09.09.507368 — synthetic biology — Posted on 2023-01-30

164 Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-specific Transcriptome and Molecular Subtype

Bahrambeigi, V.; Lee, J. J.; Branchi, V.; Henry, J. T.; Rajapakshe, K. I.; Stephens, B. M.; Dhebat, S.; Hurd, M. W.; Sun, R.; Yang, P.; Wang, W.; Kopetz, S. E.; Maitra, A.; Guerrero, P. A.; Xu, Z.; Wang, K.; Ruppin, E.

10.1101/2022.10.27.514047 — cancer biology — Posted on 2023-01-30

165 Benchmarking software to predict antibiotic resistance phenotypes in shotgun metagenomes using simulated data

Wissel, E. F.; Talbot, B. M.; Toyosato, N. A. B.; Petit, R. A.; Hertzberg, V.; Dunlop, A.; Read, T. D.

10.1101/2022.01.13.476279 — bioinformatics — Posted on 2023-01-30

166 Comparison of gene set scoring methods for reproducible evaluation of multiple tuberculosis gene signatures

Wang, X.; Vanvalkenburg, A.; Odom-Mabey, A. R.; Ellner, J. J.; Hochberg, N. S.; Salgame, P.; Patil, P.; Johnson, W. E.

10.1101/2023.01.19.520627 — bioinformatics — Posted on 2023-01-30

167 SpatialDM: Rapid identification of spatially co-expressed ligand-receptor reveals cell-cell communication patterns

LI, Z.; Wang, T.; Liu, P.; Huang, Y.

10.1101/2022.08.19.504616 — bioinformatics — Posted on 2023-01-30

168 Phenotypically Complex Living Materials Containing Engineered Cyanobacteria

Datta, D.; Weiss, E. L.; Wangpraseurt, D.; Hild, E.; Chen, S.; Golden, J. W.; Golden, S. S.; Pokorski, J. K.

10.1101/2023.01.26.525792 — bioengineering — Posted on 2023-01-30

169 Movement data link phenotypic traits to individual fitness in a nocturnal predator.

Becciu, P.; Sechaud, R.; Schalcher, K.; Plancherel, C.; Roulin, A.

10.1101/2022.08.26.505323 — animal behavior and cognition — Posted on 2023-01-30

170 Distinct roles for canonical and variant histone H3 lysine 36 in Polycomb silencing

Salzler, H. R.; Vandadi, V.; McMichael, B. D.; Brown, J. C.; Boerma, S. A.; Leatham-Jensen, M. P.; Adams, K. M.; Meers, M. P.; Simon, J. M.; Duronio, R. J.; McKay, D. J.; Matera, A. G.

10.1101/2022.10.11.511749 — genomics — Posted on 2023-01-30

171 Marching with ants to a new nest

Annagiri, S.; Halder, E.

10.1101/2023.01.27.526000 — ecology — Posted on 2023-01-30

172 Influenza A virus modulation of Streptococcus pneumoniae infection using ex vivo transcriptomics in a human primary lung epithelial cell model reveals differential host glycoconjugate uptake and metabolism

D'Mello, A.; Lane, J. R.; Tipper, J. L.; Martinez, E.; Roussey, H. N.; Harrod, K. S.; Orihuela, C. J.; Tettelin, H.

10.1101/2023.01.29.526157 — microbiology — Posted on 2023-01-30

173 Probiotics supplementation to adult human small intestinal stoma microbiota causes dynamic increase in the community resistance to perturbations and nutrient utilization

Jansma, J.; Thome, N. U.; Schwalbe, M.; Chatziioannou, A. C.; Elsayed, S. S.; van Wezel, G.; van den Abbeele, P.; van Hemert, S.; El Aidy, S.

10.1101/2023.01.29.525861 — microbiology — Posted on 2023-01-30

174 Improved Ethanol Tolerance and Production in Pyruvate Dehydrogenase Mutant of Saccharomyces cerevisiae

Yang, A.; Ranaivoarisoa, T. O.; Bose, A.

10.1101/2023.01.29.526136 — microbiology — Posted on 2023-01-30

175 The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular senescence and drug resilience.

Tripathi, J.; Stoklasa, M.; Nayak, S.; Low, K. E.; Lee, E. Q. H.; Renia, L.; Malleret, B.; Bozdech, Z.

10.1101/2023.01.29.526019 — microbiology — Posted on 2023-01-30

176 The virus-encoded ion channel "viroporin" activity of the agnoprotein is required for BK Polyomavirus release from infected kidney cells

Swinscoe, G.; Prescott, E. L.; Hurdiss, D. L.; Morgan, E. L.; Dobson, S. J.; Edwards, T. A.; Foster, R.; Welberry-Smith, M.; Macdonald, A. A.

10.1101/2023.01.30.526200 — microbiology — Posted on 2023-01-30

177 Seasonal Shifts in Community Composition and Proteome Expression in a Sulfur-Cycling Cyanobacterial Mat

Grim, S. L.; Stuart, D. G.; Aron, P.; Levin, N. E.; Kinsman-Costello, L. E.; Waldbauer, J. E.; Dick, G. J.

10.1101/2023.01.30.526236 — microbiology — Posted on 2023-01-30

178 Accounting for 16S rRNA copy number prediction uncertainty and its implications in microbial diversity analyses

Gao, Y.; Wu, M.

10.1101/2021.08.31.458422 — microbiology — Posted on 2023-01-30

179 Loss of WNT5 Proteins Reprograms Neutrophils in the Spleen to Provide Protection for DSS-Induced Colitis

Luan, Y.; Hu, J.; Wang, Q.; Li, W.; Wang, X.; Qu, R.; Rajendran, B. K.; Zhou, H.; Liu, P.; Shi, Y.; Liu, Y.; Lu, J.; Tang, W.; Wu, D.

10.1101/2023.01.28.526056 — immunology — Posted on 2023-01-30

180 Oxidized MIF is an Alzheimer's Disease drug target relaying external risk factors to tau pathology

Mueller-Schiffmann, A.; Torres, F.; Kitaygorodskyy, A.; Ramani, A.; Alatza, A.; Tschirner, S.; Prikulis, I.; Yu, S.; Dey, D.; Mallesh, S.; Prasad, D.; Solas, D.; Bader, V.; Rozemuller, A.; Wray, S.; Gopalakrishnan, J.; Riek, R.; Lingappa, V. R.; Korth, C.

10.1101/2021.09.11.459903 — neuroscience — Posted on 2023-01-30

181 Deletion of genes linked to the C1-fixing gene cluster affects growth, by-products, and proteome of Clostridium autoethanogenum

Nwaokorie, U. J.; Reinmets, K.; de Lima, L. A.; Pawar, P. R.; Shaikh, K. M.; Harris, A.; Köpke, M.; Valgepea, K.

10.1101/2023.01.30.526161 — synthetic biology — Posted on 2023-01-30

182 Over-expression of ADAR1 in mice does not initiate or accelerate cancer formation in vivo.

Mendez Ruiz, S.; Chalk, A.; Goradia, A.; Heraud-Farlow, J.; Walkley, C.

10.1101/2023.01.29.526130 — cancer biology — Posted on 2023-01-30

183 m6A Demethylase FTO Stabilizes LINK-A to Exert Oncogenic Roles via MCM3-Mediated Cell Cycle Progression and HIF-1α Activation

Nan, Y.; Liu, S.; Luo, Q.; Wu, X.; Zhao, P.; Chang, W.; Liu, Z.

10.1101/2023.01.28.526069 — cancer biology — Posted on 2023-01-30

184 How cells wrap around virus-like particles using extracellular filamentous protein structures

Gupta, S.; Santangelo, C. D.; Patteson, A. E.; Schwarz, J. M.

10.1101/2023.01.30.526272 — biophysics — Posted on 2023-01-30

185 PPAD: A deep learning architecture to predict progression of Alzheimer's disease

Al Olaimat, M. A.; Martinez, J.; Saeed, F.; Bozdag, S.

10.1101/2023.01.28.526045 — bioinformatics — Posted on 2023-01-30

186 Programmable RNA detection with CRISPR-Cas12a

Rananaware, S. R.; Vesco, E. K.; Shoemaker, G. M.; Anekar, S. S.; Sandoval, L. S. W.; Meister, K. S.; Macaluso, N. C.; Nguyen, L. T.; Jain, P. K.

10.1101/2023.01.29.525716 — bioengineering — Posted on 2023-01-30

187 A simple, flexible and high-efficiency western blot analysis for age-related human induced neurons

Shen, Y.-F.; Liu, M.-J.; Long, Z.; Shi, X.; Liu, M.-L.

10.1101/2023.01.30.526150 — biochemistry — Posted on 2023-01-30

188 DTX3L and USP28 fine-tune DNA double strand repair through mutual regulation of their protein levels

Ashok, Y.; Mennerich, D.; Vela-Rodriguez, C.; Alanen, H. I.; Rall-Scharpf, M.; Wiesmuller, L.; Prunskaite-Hyyrylainen, R.; Lehtio, L.; Kietzmann, T.

10.1101/2023.01.30.526213 — biochemistry — Posted on 2023-01-30

189 A New Platform for Label-Free, Proximal Cellular Pharmacodynamic Assays: Identification of Glutaminase Inhibitors Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

Pu, F.; Radosevich, A. J.; Bruckner, B. G.; Fontaine, D. A.; Panchal, S. C.; Williams, J. D.; Gopalakrishnan, S. M.; Elsen, N. L.

10.1101/2023.01.30.526319 — biochemistry — Posted on 2023-01-30

190 Structure of a Membrane Tethering Complex Incorporating Multiple SNAREs

DAmico, K. A.; Stanton, A. E.; Shirkey, J. D.; Travis, S. M.; Jeffrey, P. D.; Hughson, F. M.

10.1101/2023.01.30.526244 — biochemistry — Posted on 2023-01-30

191 Identification of functional Npu DnaE and gp41-1 inteins split in three fragments

Weis, D.; Palanisamy, N.; Ballestin Ballestin, J.; Oeztuerk, M. A.; Di Ventura, B.

10.1101/2023.01.30.526203 — molecular biology — Posted on 2023-01-30

192 An optimized workflow for analyzing extracellular vesicles as biomarkers in liver diseases.

Paluschinski, M.; Loosen, S.; Kordes, C.; Keitel, V.; Kuebart, A.; Brandenburger, T.; Schoeler, D.; Wammers, M.; Neumann, U.; Luedde, T.; Castoldi, M.

10.1101/2023.01.30.526180 — molecular biology — Posted on 2023-01-30

193 G-quadruplexes regulate miRNA biogenesis in live zebrafish embryos

Steeman, T. J.; Weiner, A. M. J.; David, A. P.; Binolfi, A.; Calcaterra, N. B.; Armas, P.

10.1101/2023.01.30.526225 — molecular biology — Posted on 2023-01-30

194 Adaptive and maladaptive consequences of deregulation in a bacterial gene regulatory network

Vinchhi, R.; Yelpure, C.; Balachandran, M.; Matange, N.

10.1101/2023.01.30.526227 — microbiology — Posted on 2023-01-30

195 Structure of the Native Chemotaxis Core Signalling Unit from E-gene lysed E. coli cells

Cassidy, C. K.; Qin, Z.; Frosio, T.; Gosink, K.; Yang, Z.; Sansom, M.; Stansfeld, P.; Parkinson, J. S.; Zhang, P.

10.1101/2023.01.30.526190 — microbiology — Posted on 2023-01-30

196 Rapid metagenomic sequencing for diagnosis and antimicrobial sensitivity prediction of canine bacterial infections

Ring, N.; Low, A. S.; Wee, B.; Paterson, G. K.; Nuttall, T.; Mellanby, R.; Gally, D.; Fitzgerald, J. R.

10.1101/2023.01.30.526267 — microbiology — Posted on 2023-01-30

197 Homeostatic control of an iron repressor in a GI tract resident

Wang, Y.; Mao, Y.; Chen, X.; Yang, K.; Huang, X.; Tian, L.; Jiang, T.; Zou, Y.; Ma, X.; Xu, C.; Zhou, Z.; Wu, X.; Pan, L.; Liang, H.; Chen, C.

10.1101/2023.01.30.526184 — microbiology — Posted on 2023-01-30

198 Co-evolutionary patterns shown in Ostreococcus-virus system from the Western Baltic Sea in freshly isolated hosts and viruses.

Listmann, L.; Peters, C.; Rahlff, J.; Esser, S. P.; Schaum, E.

10.1101/2023.01.30.526186 — microbiology — Posted on 2023-01-30

199 Dual RNA-seq identifies proteins and pathways modulated during Clostridioides difficile colonisation

Frost, L. R.; Stark, R.; Anonye, B.; Ferreira, L. R. P.; Unnikrishnan, M.

10.1101/2023.01.30.526182 — microbiology — Posted on 2023-01-30

200 Reciprocal regulation of TLR4, TLR3 and Macrophage Scavenger Receptor 1 regulates nonopsonic phagocytosis of the fungal pathogen Cryptococcus neoformans.

Onyishi, C. U.; Desanti, G. E.; Wilkinson, A. L.; Fejer, G.; Christophe, O. D.; Bryant, C. E.; Mukhopadhyay, S.; Gordon, S.; May, R. C.

10.1101/2023.01.30.525903 — microbiology — Posted on 2023-01-30

201 Phosphorylation of the inner core oligosaccharide of lipopolysaccharide mediates recognition and phagocytosis of Gram-negative bacteria by Brain Angiogenesis Inhibitor 1 (BAI1)

Billings, E. A.; Columbus, L.; Casanova, J. E.

10.1101/2023.01.30.525907 — microbiology — Posted on 2023-01-30

202 Structure of the PfRCR complex which bridges the malaria parasite and erythrocyte during invasion

Farrell, B.; Alam, N.; Hart, M.; Jamwal, A.; Ragotte, R.; Walters-Morgan, H.; Draper, S.; Knuepfer, E.; Higgins, M. K.

10.1101/2023.01.30.526221 — microbiology — Posted on 2023-01-30

203 Invasive Californian death caps develop mushrooms unisexually and bisexually

Wang, Y.-W.; McKeon, M.; Elmore, H.; Hess, J.; Golan, J.; Gage, H.; Mao, W.; Harrow, L.; Goncalves, S.; Hull, C.; Pringle, A.

10.1101/2023.01.30.525609 — microbiology — Posted on 2023-01-30

204 Extracellular vesicles production regulates fluconazole resistance in Cryptococcus neoformans

Rizzo, J.; Trottier, A.; Moyrand, F.; Coppee, J.-Y.; Maufrais, C.; Zimbres, A. C. G.; Dang, T. T. V.; Alanio, A.; Desnos-Ollivier, M.; Mouyna, I.; PEHAU-ARNAUDET, G.; Commere, P.-H.; Novault, S.; Ene, I. V.; Nimrichter, L.; Rodrigues, M.; Janbon, G.

10.1101/2023.01.30.526212 — microbiology — Posted on 2023-01-30

205 A common tolerance mechanism of bacterial biofilms to antibiotics

Zhang, Y.; Cai, Y.; Wang, T.; Wu, Q.

10.1101/2023.01.30.526163 — microbiology — Posted on 2023-01-30

206 Talk To A Scientist: A Framework for a Webinar-Based Science Outreach Platform for Children

Mhade, S.; Kadam, S.; Kaushik, K.

10.1101/2023.01.28.523869 — scientific communication and education — Posted on 2023-01-30

207 Too bad to be fraud, Midjourney has yet to embark in science.

Cammer, M.

10.1101/2023.01.28.526052 — scientific communication and education — Posted on 2023-01-30

208 An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment

YANG, D.; Li, J.; Zhang, T.; Shi, Q.; Lv, G.; Zhou, X.; CHOUDHRY, N.; Kalashova, J.; Yang, C.; Li, H.; Long, Y.; Sakthivel, B.; Nimishetti, N.; Liu, H.; Allen, T. D.; Zhang, J.

10.1101/2023.01.29.526078 — cancer biology — Posted on 2023-01-30

209 Human Amylin in the Presence of SARS-COV-2 Protein Fragments

Chesney, A. D.; Maiti, B.; Hansmann, U. H. E.

10.1101/2023.01.30.526275 — biophysics — Posted on 2023-01-30

210 Decontamination of ambient and margin noise in droplet-based single cell protein expression data with DecontPro

Yin, Y.; Yajima, M.; Campbell, J. D.

10.1101/2023.01.27.525964 — bioinformatics — Posted on 2023-01-30

211 A dual diffusion model enables 3D binding bioactive molecule generation and lead optimization given target pockets

Huang, L.

10.1101/2023.01.28.526011 — bioinformatics — Posted on 2023-01-30

212 Explainable prediction of catalysing enzymes from reactions using multilayer perceptrons

Probst, D.

10.1101/2023.01.28.526009 — bioinformatics — Posted on 2023-01-30

213 HTLV-1 Splice Sites in Prevalent Gene VectorsCause Splicing Perturbations in Transgenic Human Cells

Miskey, C.; Prommersberger, S.; Mestermann, K.; Hudecek, M.; Ivics, Z.

10.1101/2023.01.28.526022 — genomics — Posted on 2023-01-30

214 Duck pan-genome reveals two transposon-derived structural variations caused bodyweight enlarging and white plumage phenotype formation during evolution

Wang, K.; Hua, G.; Li, J.; Yang, Y.; Zhang, C.; Yang, L.; Hu, X.; Scheben, A.; Wu, Y.; Gong, P.; Zhang, S.; Fan, Y.; Zeng, T.; Lu, L.; Gong, Y.; Jiang, R.; Sun, G.; Tian, Y.; Kang, X.; Hu, H.; Li, W.

10.1101/2023.01.28.526061 — genetics — Posted on 2023-01-30

215 Trophic eggs affect caste determination in the ant Pogonomyrmex rugosus

Genzoni, E.; Schwander, T.; Keller, L.

10.1101/2023.01.28.525977 — evolutionary biology — Posted on 2023-01-30

216 lydemapr: an R package to track the spread of the invasive Spotted Lanternfly (Lycorma delicatula, White 1845) (Hemiptera, Fulgoridae) in the United States

De Bona, S.; Barringer, L.; Kurtz, P.; Losiewicz, J.; Parra, G. R.; Helmus, M. R.

10.1101/2023.01.27.525992 — ecology — Posted on 2023-01-30

217 Changes in biodiversity impact atmospheric chemistry through plant volatiles and particles

Sanaei, A.; Hermann, H.; Alshaabi, L.; Beck, J.; Ferlian, O.; Wadinga Fomba, K.; Haferkorn, S.; van Pinxteren, M.; Quaas, J.; Quosh, J.; Rabe, R.; Wirth, C.; Eisenhauer, N.; Weigelt, A.

10.1101/2023.01.28.526055 — ecology — Posted on 2023-01-30

218 INHIBITORY EFFECTS OF GLUCOCORTICOID ON IMMUNOCYTES

Wu, S.; Zhao, S.; Zhong, Y.; Wang, B.

10.1101/2023.01.28.525640 — immunology — Posted on 2023-01-30

219 Examining Horizontal Transmission of Nippostrongylus brasiliensis in Mice to Assess Biosecurity Risks

Floyd, R. J.; Ricart Arbona, R. J.; Carrasco, S. E.; Lipman, N. S.

10.1101/2023.01.28.526042 — immunology — Posted on 2023-01-30

220 A mouse model of hormonal contraceptive exposure: depression, motivation, and the stress response

Schuh, K. M.; Ahmed, J.; Kwak, E.; Xu, C. X.; Davis, T. T.; Aronoff, C. B.; Tronson, N. C.

10.1101/2023.01.27.525969 — neuroscience — Posted on 2023-01-30

221 The parasubthalamic nucleus refeeding ensemble delays feeding initiation

Dunning, J. L.; Lopez, C.; Krull, C.; Kreifeldt, M.; Angelo, M.; Ramakrishnan, C.; Deisseroth, K.; Contet, C.

10.1101/2023.01.28.525750 — neuroscience — Posted on 2023-01-30

222 Network analysis reveals strain-dependent response to misfolded tau aggregates

Acri, D. J.; You, Y.; Tate, M. D.; McCord, B.; Sharify, A. D.; John, S. K.; Karahan, H.; Kim, B.; Dabin, L. C.; Philtjens, S.; Wijeratne, H. R. S.; McCray, T. J.; Smith, D. C.; Bissel, S. J.; Lamb, B. T.; Lasagna-Reeves, C. A.; Kim, J.

10.1101/2023.01.28.526029 — neuroscience — Posted on 2023-01-30

223 Subcortical correlates of consciousness with human single neuron recordings

Pereira, M.; Faivre, N.; Bernasconi, F.; Brandmeir, N.; Suffridge, J.; Tran, K.; Wang, S.; Finomore, V.; Konrad, P.; Rezai, A.; Blanke, O.

10.1101/2023.01.27.525684 — neuroscience — Posted on 2023-01-30

224 Intralimb locomotor coordination in rats walking on asymmetric pegway

Hanna, K. E.; Salido, E. M.; Lal, N.; Tuntevski, K.; Yakovenko, S.

10.1101/2023.01.27.525960 — neuroscience — Posted on 2023-01-30

225 Live cell imaging and CLEM reveals effects of Mutant Huntingtin Aggregation Process

YIGIT, E. N.; AYDIN, M. S.; AKSAN KURNAZ, I.; EROGLU, E.; Ozturk, G.

10.1101/2023.01.28.526012 — neuroscience — Posted on 2023-01-30

226 Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization-An In Vivo Rat Model

Wang, D.; Lai, A.; Gansau, J.; Seifert, A.; Munitz, J.; Zaheer, K.; Bhadouria, N.; Lee, Y.; Nasser, P.; Laudier, D.; Holguin, N.; Hecht, A.; Iatridis, J. C.

10.1101/2023.01.27.525924 — pathology — Posted on 2023-01-30

227 Tackling hysteresis in conformational sampling - how to be forgetful with MEMENTO

Lichtinger, S. M.; Biggin, P. C.

10.1101/2023.01.28.525919 — biophysics — Posted on 2023-01-30

228 Acoustic trapping and navigation of microrobots in the mouse brain vasculature

Fonseca, A. D. C.; Gluck, C.; Droux, J.; Ferry, Y.; Frei, C.; Wegener, S.; Weber, B.; El Amki, M.; Ahmed, D.

10.1101/2023.01.28.522839 — bioengineering — Posted on 2023-01-30

229 Multifunctional ferromagnetic fiber robots for navigation, sensing, and treatment in minimally invasive surgery

Zhang, Y.; Wu, X.; Vadlamani, R. A.; Lim, Y.; Kim, J.; David, K.; Gilbert, E.; Li, Y.; Wang, R.; Jiang, S.; Wang, A.; Sontheimer, H.; English, D.; Emori, S.; Davalos, R. V.; Poelzing, S.; Jia, X.

10.1101/2023.01.27.525973 — bioengineering — Posted on 2023-01-30

230 Sustained Delivery of GLP-1 Receptor Agonists from Injectable Biomimetic Hydrogels Improves Treatment of Diabetes

d'Aquino, A. I.; Maikawa, C. L.; Nguyen, L. T.; Lu, K.; Hall, I. A.; Prossnitz, A. N.; Chang, E.; Baker, S. W.; Kasse, C. I.; Jons, C. K.; Yan, J.; Hovgaard, L.; Steensgaard, D. B.; Andersen, H. B.; Simonsen, L.; Appel, E. A.

10.1101/2023.01.28.526057 — bioengineering — Posted on 2023-01-30

231 Can a Fish Learn to Ride a Bicycle? Sensorimotor Adaptation to Destabilizing Dynamics in Weakly Electric Fish

Yang, Y.; Yared, D. G.; Cowan, N. J.

10.1101/2023.01.27.525956 — animal behavior and cognition — Posted on 2023-01-30

232 movedesign: Shiny R app to evaluate sampling design for animal tracking movement studies

Silva, I.; Fleming, C. H.; Noonan, M. J.; Fagan, W. F.; Calabrese, J. M.

10.1101/2023.01.27.525894 — ecology — Posted on 2023-01-30

233 Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2

Barreiro, A.; Prenafeta, A.; Bech-Sabat, G.; Roca, M.; Perozo, E.; March, R.; Gonzalez-Gonzalez, L.; Madrenas, L.; Corominas, J.; Fernandez, A.; Moros, A.; Molas, M.; Pentinat-Pelegrin, T.; Panosa, C.; Moreno, A.; Puigvert, E.; Pol, E.; Palmada, J.; Garriga, C.; Prat, T.; Iglesias-Fernandez, J.; Vergara-Alert, J.; Lorca-Oro, C.; Roca, N.; Fernandez-Bastit, L.; Rodon, J.; Perez, M.; Segales, J.; Pradenas, E.; Marfil, S.; Trinite, B.; Ortiz, R.; Clotet, B.; Blanco, J.; Diaz Pedroza, J.; Ampudia Carrasco, R.; Rosales Salgado, Y.; Loubat Casanovas, J.; Capdevila Larripa, S.; Garcia Prado, J.; Barr

10.1101/2021.11.22.469117 — immunology — Posted on 2023-01-30

234 Competition between bottom-up visual input and internal inhibition generates error neurons in a model of the mouse primary visual cortex

Mirasso, C. R.; Fraile, J. G.; Scherr, F.; Ramasco, J. J.; Arkhipov, A.; Maass, W.

10.1101/2023.01.27.525984 — neuroscience — Posted on 2023-01-30

235 Causal inference during closed-loop navigation: parsing of self- and object-motion

Noel, J.-P.; Bill, J.; Ding, H.; Vastola, J.; DeAngelis, G. C.; Angelaki, D.; Drugowitsch, J.

10.1101/2023.01.27.525974 — neuroscience — Posted on 2023-01-30

236 Probabilistic mixture models improve calibration of panel-derived tumor mutational burden in the context of both tumor-normal and tumor-only sequencing

Anaya, J.; Sidhom, J.-W.; Cummings, C. A.; Baras, A. S.; the AACR Project GENIE Consortium,

10.1101/2022.04.22.489230 — bioinformatics — Posted on 2023-01-30

237 Systematic conformation-to-phenotype mapping via limited deep-sequencing of proteins

Serebryany, E.; Zhao, V. Y.; Park, K.; Bitran, A.; Trauger, S. A.; Budnik, B.; Shakhnovich, E. I.

10.1101/2022.04.12.488104 — biophysics — Posted on 2023-01-30

238 A Systematic Approach to the Discovery of Protein-Protein Inter-action Stabilizers

Kenanova, D. N.; Visser, E. J.; Virta, J. M.; Sijbesma, E.; Centorrino, F.; Vickery, H. R.; Zhong, M.; Neitz, J. R.; Brunsveld, L.; Ottmann, C.; Arkin, M. R.

10.1101/2023.01.29.526112 — biochemistry — Posted on 2023-01-30

239 Kinetic modelling of sterol transport between plasma membrane and endo-lysosomes based on quantitative fluorescence and X-ray imaging data

Wüstner, D.; Juhl, A. D.; Egebjerg, J.; Werner, S.; McNally, J. G.; Schneider, G.

10.1101/2023.01.28.526075 — biophysics — Posted on 2023-01-30

240 Beyond sequence similarity: cross-phyla protein annotation by structural prediction and alignment

Ruperti, F.; Papadopoulos, N.; Musser, J.; Mirdita, M.; Steinegger, M.; Arendt, D.

10.1101/2022.07.05.498892 — evolutionary biology — Posted on 2023-01-30

241 Quantifying single cell lipid signaling kinetics after photo-stimulation

Gonzales, D. T.; Schuhmacher, M.; Lennartz, H. M.; Iglesias-Artola, J. M.; Kuhn, S. M.; Barahtjan, P.; Zechner, C.; Nadler, A.

10.1101/2023.01.27.525833 — cell biology — Posted on 2023-01-30

242 Capturing effects of blood flow on the transplanted decellularized nephron with intravital microscopy

Corridon, P. R.

10.1101/2021.02.10.430561 — physiology — Posted on 2023-01-30

243 Over the hills and far away: linking landscape factors with cavity excavation on living forest trees by the Black woodpecker (Dryocopus martius, L. 1758)8)

Cabrera, C.; Monnet, J.-M.; Boutteaux, J.-J.; Doutau, B.; Denis, P.; Paillet, Y.

10.1101/2022.06.22.497197 — ecology — Posted on 2023-01-30

244 Accounting for endogenous effects in decision-making with a non-linear diffusion decision model

Hoxha, I.; Chevallier, S.; Ciarchi, M.; Glasauer, S.; Delorme, A.; Amorim, M.-A.

10.1101/2022.07.18.498922 — neuroscience — Posted on 2023-01-30

245 A computational account of needing and wanting

Bosulu, J.; Pezzulo, G.; Hetu, S.

10.1101/2022.10.24.513547 — neuroscience — Posted on 2023-01-30

246 Angiotensin blockade enhances motivational reward learning via enhancing ventral striatal prediction error and frontostriatal communication

Xu, T.; Zhou, X.; Kanen, J. W.; Wang, L.; Chen, Z.; Zhang, R.; Jiao, G.; Feng, Z.; Zhao, W.; Yao, S.; Becker, B.

10.1101/2022.03.14.484364 — neuroscience — Posted on 2023-01-30

247 Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses

Mahfooz, K.; Rodriguez Gotor, J. J.; Wesseling, J.

10.1101/2020.08.14.251975 — neuroscience — Posted on 2023-01-30

248 An electrostatic cluster guides Abeta fibril formation in cerebral amyloid angiopathy

Crooks, E. J.; Fu, Z.; Irizarry, B. A.; Zhu, X.; Van Nostrand, W. E.; Chowdhury, S.; Smith, S. O.

10.1101/2022.12.22.521588 — neuroscience — Posted on 2023-01-30

249 The transcriptome of soybean reproductive tissues subjected to water deficit, heat stress, and a combination of water deficit and heat stress.

Sinha, R.; Induri, S. P.; Pelaez-Vico, M. A.; Tukuli, A.; Shostak, B.; Zandalinas, S. I.; Joshi, T.; Fritschi, F. B.; Mittler, R.

10.1101/2023.01.29.526088 — plant biology — Posted on 2023-01-30

250 Spatio-temporal evaluation of drought adaptation in wheat revealed NDVI and MTSI as powerful tools for selecting tolerant genotypes

S, S. R.; Singh, G. M.; Kumar, U.; Bhati, P.; Vishwakarma, M.; Navathe, S.; J, Y. K.; Sharma, S.; Mishra, V. K.; Joshi, A. K.

10.1101/2023.01.29.526148 — plant biology — Posted on 2023-01-30

251 Finemap-MiXeR: A variational Bayesian approach for genetic finemapping

Akdeniz, B. C.; Frei, O.; Shadrin, A.; Vetrov, D.; Kropotov, D.; Dale, A.; Hovig, E.; Andreassen, O.

10.1101/2022.11.30.518509 — bioinformatics — Posted on 2023-01-30

252 Two-photon targeted, quad whole-cell patch clamping robot

Gonzalez, G. I. V.; Kgwarae, P. O.; Schultz, S. R.

10.1101/2022.11.14.516499 — bioengineering — Posted on 2023-01-30

253 Extending eco-evolutionary theory with oligomorphic dynamics

Lion, S.; Sasaki, A.; Boots, M.

10.1101/2022.12.12.520082 — evolutionary biology — Posted on 2023-01-30

254 A First Ultrastructural and Immuno-Labelling Investigation of Western Red Cedar Leaves

Gowen, B. E.; Noshad, D.

10.1101/2023.01.28.526058 — plant biology — Posted on 2023-01-30

255 HEXOKINASE-dependent regulation of WRKY transcription factors in Arabidopsis

Boyte, J. M.; Xie, R.; Liu, Y.; Li, X.; Buckley, C. R.; Haydon, M. J. J.

10.1101/2023.01.29.526134 — plant biology — Posted on 2023-01-30

256 Development of a new bioinspired peptide with fibroblast relaxation proprieties for cosmetics applications

Mortari, M. R.; Silva Ramalho, J. D.; Camargo, N. S.; Ferreira, G. A.; Andrade, S. S.; Longo, J. P. F.

10.1101/2023.01.27.525652 — biochemistry — Posted on 2023-01-30

257 Predictability shifts from local to global rules during bacterial adaptation

Couce, A.; Magnan, M.; Lenski, R. E.; Tenaillon, O.

10.1101/2022.05.17.492360 — evolutionary biology — Posted on 2023-01-30

258 The Labbing Project: A database management application for neuroimaging research

Baratz, Z.; Assaf, Y.

10.1101/2023.01.02.522426 — bioinformatics — Posted on 2023-01-30

259 The post-translational modification profile of TAR DNA-Binding Protein (TDP-43) in platelets of patients with Alzheimer's disease: An exploratory study for blood-based biomarker development.

Johnson, Q.; Hadjian, M.; Bah, A.; Smith, S.; Kosa, E.; Agbas, A.

10.1101/2023.01.29.526122 — neuroscience — Posted on 2023-01-30

260 Geodesic theory of long association fibers guidance on the human fetal cortex

Horibe, K.; Taga, G.; Fujimoto, K.

10.1101/2023.01.29.526048 — neuroscience — Posted on 2023-01-29

261 Spectro-temporal acoustical markers differentiate speech from song across cultures

Albouy, P.; Mehr, S. A.; Hoyer, R. S.; Ginzburg, J.; Zatorre, R. J.

10.1101/2023.01.29.526133 — neuroscience — Posted on 2023-01-29

262 Myeloperoxidase promotes a tumorigenic microenvironment in non-small cell lungcancer

Valadez-Cosmes, P.; Kathrin, M.; Kindler, O.; Cosic-Mujkanovic, N.; Lueger, A.; Raftopoulou, S.; Kienzl, M.; Mihalic, Z. N.; Santiso, A.; Sarsembayeva, A.; Brcic, L.; Lindenmann, J.; Sattler, W.; Heinemann, A.; Schicho, R.; Marsche, G.; Houghton, A. M.; Kargl, J.

10.1101/2023.01.28.526014 — cancer biology — Posted on 2023-01-29

263 ChromDL: A Next-Generation Regulatory DNA Classifier

Hill, C.; Hudaiberdiev, S.; Ovcharenko, I.

10.1101/2023.01.27.525971 — genomics — Posted on 2023-01-29

264 Poles apart - the structure and composition of the bird community in bamboo in the Eastern Himalaya

Srinivasan, S.; Srinivasan, U.

10.1101/2023.01.27.525938 — ecology — Posted on 2023-01-29

265 Delivering mRNAs to mouse tissues using the SEND system

Ohtsuka, M.; Imafuku, J.; Hori, S.; Kurosaki, A.; Nakamura, A.; Nakahara, T.; Yahata, T.; Bhat, K.; Papastefan, S.; Nakagawa, S.; Quadros, R. M.; Miura, H.; Gurumurthy, C. B.

10.1101/2023.01.28.522652 — genomics — Posted on 2023-01-29

266 Methods for the analysis of skin microbiomes: a comparison of sampling processes and 16S rRNA hypervariable regions.

Alyami, R. Y.; Cleary, D. W.; Forster, J.; Feelisch, M.; Ardern-Jones, M. R.

10.1101/2023.01.28.525888 — microbiology — Posted on 2023-01-29

267 EB1 decoration of microtubule lattice facilitates spindle-kinetochore lateral attachment in Plasmodium male gametogenesis

Yang, S.; Cai, M.; Huang, J.; Zhang, S.; Mo, X.; Jiang, K.; Cui, H.; Yuan, J.

10.1101/2023.01.29.525995 — microbiology — Posted on 2023-01-29

268 Amphiphiles formed from synthetic DNA-nanomotifs mimic the dispersal of transcriptional clusters in the cell nucleus

Tschurikow, X.; Gadzekpo, A.; Tran, M. P.; Chatterjee, R.; Sobucki, M.; Zaburdaev, V.; Goepfrich, K.; Hilbert, L.

10.1101/2023.01.29.525851 — synthetic biology — Posted on 2023-01-29

269 Performant web-based interactive visualization tool for spatially-resolved transcriptomics experiments

Sriworarat, C.; Nguyen, A. B.; Eagles, N. J.; Collado-Torres, L.; Martinowich, K.; Maynard, K. R.; Hicks, S. C.

10.1101/2023.01.28.525943 — bioinformatics — Posted on 2023-01-29

270 Structural characterization and extended substrate scope analysis of two Mg2+-dependent O-methyltransferases from bacteria

Sokolova, N.; Zhang, L.; Deravi, S.; Oerlemans, R.; Groves, M. R.; Haslinger, K.

10.1101/2023.01.28.526015 — biochemistry — Posted on 2023-01-29

271 Transcriptomic impacts and potential routes of detoxification in a lampricide-tolerant teleost exposed to TFM and niclosamide

Lawrence, M. J.; Grayson, P.; Jeffrey, J.; Docker, M.; Garroway, C. J.; Wilson, J.; Manzon, R.; Wilkie, M.; Jeffries, K.

10.1101/2023.01.29.526103 — genomics — Posted on 2023-01-29

272 Multi-omics Comparison among Populations of Three Plant Sources of Amomi Fructus

Chen, X.; Sun, S.; Han, X.; Li, C.; Nie, B.; Hou, Z.; Ji, J.; Han, X.; Zhang, L.; Yue, J.; Yang, D.; Wang, L.

10.1101/2023.01.27.525993 — evolutionary biology — Posted on 2023-01-29

273 Chimeric chikungunya virus-like particles with surface exposed SARS-CoV-2 RBD elicits potent immunogenic responses in mice.

Singh, V. A.; Nehul, S.; Kumar, C. S.; Banerjee, M.; Kumar, P.; Sharma, G.; Tomar, S.

10.1101/2023.01.29.526074 — molecular biology — Posted on 2023-01-29

274 Bacterial vaginosis is associated with increased amylolytic activity

Hertzberger, R.; Himschoot, L.; Bruisten, S.; Steenbergen, L.; Lewis, W.; Cools, P.; Kort, R.

10.1101/2023.01.28.526025 — microbiology — Posted on 2023-01-29

275 Intracellular diversity of WNV within circulating avian peripheral blood mononuclear cells reveals host-dependent patterns of polyinfection

Talmi-Frank, D.; Byas, A.; Murrieta, R.; Weger-Lucarelli, J.; Rückert, C.; Gallichotte, E.; Yoshimoto, J.; Bosco-Lauth, A.; Graham, B.; Felix, T.; Brault, A.; Ebel, G.

10.1101/2023.01.27.525959 — microbiology — Posted on 2023-01-29

276 Bovine brucellosis: seroprevalence, risk factors and assessment of knowledge, attitude, and practice of cattle owners in Lare and Jikawo districts of Gambella region, Ethiopia

Kumsa, T. Z.; Borena, B. M.; Derib, B. T.; Gichile, A. G.; Marami, L. M.

10.1101/2023.01.26.525782 — microbiology — Posted on 2023-01-29

277 Staphylococcal secreted cytotoxins are competition sensing signals for Pseudomonas aeruginosa

Wang, G. Z.; Warren, E. A.; Haas, A. L.; Pena, A. S.; Kiedrowski, M. R.; Lomenick, B.; Chou, T.-F.; Bomberger, J. M.; Tirrell, D. A.; Limoli, D. H.

10.1101/2023.01.29.526047 — microbiology — Posted on 2023-01-29

278 Omicron BA.1 breakthrough infection drives long-term remodeling of the memory B cell repertoire in vaccinated individuals.

Sokal, A.; Barba-Spaeth, G.; Hunault, L.; Fernandez, I.; Broketa, M.; Meola, A.; Fourati, S.; Azzaoui, I.; Vandenberghe, A.; Lagouge-Roussey, P.; Broutin, M.; Roeser, A.; Bouvier-Alias, M.; Crickx, E.; Languille, L.; Michel, M.; Godeau, B.; Gallien, S.; Melica, G.; Nguyen, Y.; Canoui-Poitrine, F.; Noizat-Pirenne, F.; Megret, J.; Pawlotsky, J.-M.; Fillatreau, S.; Reynaud, C.-A.; Weill, J.-C.; Rey, F. A.; Brunhs, P.; Mahevas, M.; Chappert, P.

10.1101/2023.01.27.525575 — immunology — Posted on 2023-01-29

279 Negative Impact of Daily Screen Use on Inhibitory Control Network in Preadolescence: A Two-Year Follow-Up Study

Chen, Y.-Y.; Yim, H.; Lee, T.-H.

10.1101/2022.02.22.481547 — neuroscience — Posted on 2023-01-29

280 Arrhythmia-associated Calmodulin Variants Interact with KCNQ1 to Confer Aberrant Membrane Trafficking and Function

Kang, P. w.; Woodbury, L.; Angsutararux, P.; Sambare, N.; Shi, J.; Marras, M.; Abella, C.; Bedi, A.; Zinn, D.; Cui, J.; Silva, J. R.

10.1101/2023.01.28.526031 — biophysics — Posted on 2023-01-29

281 demuxmix: Demultiplexing oligonucleotide-barcoded single-cell RNA sequencing data with regression mixture models

Klein, H.-U.

10.1101/2023.01.27.525961 — bioinformatics — Posted on 2023-01-29

282 Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness

Ingelman, H.; Heffernan, J. K.; Harris, A.; Brown, S. D.; Yar Saqib, A.; Pinheiro, M. J.; de Lima, L. A.; Rodriguez Martinez, K.; Gonzalez-Garcia, R. A.; Hawkins, G.; Daleiden, J.; Tran, L.; Zeleznik, H.; Jensen, R. O.; Reynoso, V.; Simpson, S. D.; Köpke, M.; Marcellin, E.; Valgepea, K.

10.1101/2023.01.28.526018 — bioengineering — Posted on 2023-01-29

283 Biochemical deconstruction and reconstruction of the Nuclear Matrix reveal the layers of nuclear organization

Bihani, A.; Avvaru, A.; Mishra, R. K.

10.1101/2023.01.28.525997 — biochemistry — Posted on 2023-01-29

284 Kar4 is Required for the Normal Pattern of Meiotic Gene Expression

Park, Z. M.; Remillard, M.; Rose, M. D.

10.1101/2023.01.29.526097 — genetics — Posted on 2023-01-29

285 Kar4, the Yeast Homolog of METTL14, is Required for mRNA m6A Methylation and Meiosis

Park, Z. M.; Sporer, A.; Kraft, K.; Lum, K.; Blackman, E.; Belnap, E.; Yellman, C.; Rose, M. D.

10.1101/2023.01.29.526094 — genetics — Posted on 2023-01-29

286 Exponential increase in QTL detection with increased sample size.

Chitre, A. S.; Polesskaya, O.; Munro, D.; Cheng, R.; Mohammadi, P.; Holl, K.; Gao, J.; Bimschleger, H. V.; Garcia Martinez, A.; George, A.; Gileta, A. F.; Han, W.; Horvath, A.; Hughson, A.; Ishiwari, K.; King, C. P.; Lamparelli, A.; Versaggi, C. L.; Martin, C.; St. Pierre, C. L.; Tripi, J. A.; Richards, J. B.; Wang, T.; Chen, H.; Flagel, S. B.; Meyer, P.; Robinson, T. E.; Solberg Woods, L. C.; Palmer, A. A.

10.1101/2023.01.27.525982 — genetics — Posted on 2023-01-29

287 Rapid and accurate taxonomic classification of cpn60 amplicon sequence variants

Ren, Q.; Hill, J. E.

10.1101/2023.01.29.526108 — microbiology — Posted on 2023-01-29

288 Dopamine promotes Klebsiella quasivariicola proliferation and inflammatory response in the presence of macrophages

Yan, Q.; Li, X.; Cheng, L.; Liu, X.; Wang, X.; Li, R.; Fan, S.; Ma, T.; Ma, Y.; Kang, J.

10.1101/2023.01.28.526064 — microbiology — Posted on 2023-01-29

289 Development of a Data-driven Integrative Model of Bacterial Chromosome

Wasim, A.; Bera, P.; Mondal, J.

10.1101/2023.01.29.526099 — microbiology — Posted on 2023-01-29

290 Identification of levoglucosan degradation pathways in bacteria and sequence similarity network analysis

Kaur, A.; Scott, N. E.; Herisse, M.; Goddard-Borger, E. D.; Pidot, S. J.; Williams, S. J.

10.1101/2023.01.28.526070 — microbiology — Posted on 2023-01-29

McKeon, S.; Calabro, F.; Thorpe, R.; de la Fuente, A.; Foran, W.; Parr, A.; Jones, S.; Luna, B.

10.1101/2022.07.24.501317 — neuroscience — Posted on 2023-01-29

292 Neuronal responses in mouse inferior colliculus correlate with behavioral detection of amplitude modulated sound

van den Berg, M. M.; Busscher, E.; Borst, J. G. G.; Wong, A. B.

10.1101/2021.11.02.466979 — neuroscience — Posted on 2023-01-29

293 Human neurons lacking amyloid precursor protein exhibit cholesterol-associated developmental and presynaptic deficits

Mesa, H.; Zhang, E.; Wang, Y.; Zhang, Q.

10.1101/2022.12.28.522116 — neuroscience — Posted on 2023-01-29

294 If it's there, could it be a bear?

Foxon, F.

10.1101/2023.01.14.524058 — zoology — Posted on 2023-01-29

295 Pancreatic cancer risk predicted from disease trajectories using deep learning

Placido, D.; Yuan, B.; Hu, J. X.; Zheng, C.; Haue, A. D.; Chmura, P. J.; Yuan, C.; Kim, J.; Umeton, R.; Antell, G.; Chowdhury, A.; Franz, A.; Brais, L.; Andrews, E.; Marks, D.; Regev, A.; Ayandeh, S.; Brophy, M.; Do, N.; Kraft, P.; Wolpin, B. M.; Fillmore, N.; Rosenthal, M.; Brunak, S.; Sander, C.

10.1101/2021.06.27.449937 — bioinformatics — Posted on 2023-01-29

296 Co-evolution integrated deep learning framework for variants generation and fitness prediction

Tan, X.

10.1101/2023.01.28.526023 — bioinformatics — Posted on 2023-01-29

297 Motifs in SARS-CoV-2 evolution

Barrett, C.; Bura, A. C.; He, Q.; Huang, F. W.; Li, T. J. X.; Reidys, C. M.

10.1101/2023.01.27.525936 — bioinformatics — Posted on 2023-01-29

298 SARS-CoV-2 Mpro protease variants of concern display altered viral and host target processing but retain potency towards antivirals

Chen, S. A.; Arutyunova, E.; Lu, J.; Khan, M. B.; Rut, W.; Zmudzinski, M.; Shahbaz, S.; Iyyathurai, J.; Moussa, E.; Turner, Z.; Bai, B.; Lamer, T.; Nieman, J. A.; Vederas, J. C.; Julien, O.; Drag, M.; Elahi, S.; Young, H. S.; Lemieux, M. J.

10.1101/2023.01.28.525917 — biochemistry — Posted on 2023-01-29

299 Germline TFAM levels regulate mitochondrial DNA copy number and mutant heteroplasmy in C. elegans

Schwartz, A. Z.; Nance, J.

10.1101/2023.01.28.526030 — cell biology — Posted on 2023-01-29

300 Intermediate Filaments Associate with Aggresome-like Structures in Proteostressed C. elegans Neurons and Influence the Rate of Large Vesicle Extrusions as Exophers

Arnold, M. L.; Cooper, J. F.; Androwski, R.; Ardeshna, S.; Melentijevic, I.; Smart, A. J.; Guasp, R. J.; Nguyen, K. C.; Bai, G.; Hall, D. H.; Grant, B. D.; Driscoll, M.

10.1101/2022.08.03.501714 — cell biology — Posted on 2023-01-29

301 USP18 is an essential regulator of muscle cell differentiation and maturation

Olie, C. S.; Pinto-Fernandez, A.; Damianou, A.; Vendrell, I.; Mei, H.; den Hamer, B.; van der Wal, E.; de Greef, J. C.; Aronica, E.; Raz, V.; Kessler, B. M.

10.1101/2022.04.01.486741 — cell biology — Posted on 2023-01-29

302 Metacognitive Judgments during Visuomotor Learning Reflect the Integration of Error History

Hewitson, C. L.; Al-Fawakhiri, N.; McDougle, S.

10.1101/2023.01.17.524436 — neuroscience — Posted on 2023-01-29

303 Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches

Nguyen, H. A.; Fagan, C. E.; Hoffer, E. D.; Maehigashi, T.; Dunham, C. M.

10.1101/2023.01.28.526049 — biochemistry — Posted on 2023-01-29

304 Foveolar cone subtype patterning in human retinal organoids

Hussey, K.; Eldred, K.; Reh, T. A.; Johnston, R. J.

10.1101/2023.01.28.526051 — developmental biology — Posted on 2023-01-29

305 Axonal transport of autophagosomes is regulated by dynein activators JIP3/JIP4 and ARF/RAB GTPases

Cason, S. E.; Holzbaur, E. L. F.

10.1101/2023.01.28.526044 — cell biology — Posted on 2023-01-29

306 Myeloperoxidase enhances the migration of human choriocarcinoma JEG-3 cells

Mihalic, Z. N.; Kloimboeck, T.; Cosic-Mujkanovic, N.; Valadez-Cosmes, P.; Maitz, K.; Kindler, O.; Wadsack, C.; Heinemann, A.; Marsche, G.; Gauster, M.; Pollheimer, J.; Kargl, J.

10.1101/2023.01.28.526039 — cell biology — Posted on 2023-01-29

307 Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids

Kalashyan, M.; Raghunathan, K.; Oller, H.; Bayer, M.-T.; Jimenez, L.; Roland, J. T.; Kolobova, E.; Hagen, S. J.; Goldsmith, J. D.; Shub, M. D.; Goldenring, J. R.; Kaji, I.; Thiagarajah, J. R.

10.1101/2023.01.28.526036 — cell biology — Posted on 2023-01-29

308 Remote-refocusing light-sheet fluorescence microscopy enables 3D imaging of electromechanical coupling of hiPSC-derived and adult cardiomyocytes in co-culture

Dvinskikh, L.; Sparks, H.; Brito, L.; MacLeod, K. T.; Harding, S. E.; Dunsby, C.

10.1101/2023.01.28.526043 — cell biology — Posted on 2023-01-29

309 Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution

Bartos, L. M.; Kirchleitner, S. V.; Kolabas, Z. I.; Quach, S.; Blobner, J.; Mueller, S. A.; Ulukaya, S.; Hoeher, L.; Horvath, I.; Wind-Mark, K.; Holzgreve, A.; Ruf, V. C.; Gold, L.; Kunze, L. H.; Kunte, S. T.; Beumers, P.; Antons, M.; Zatcepin, A.; Briel, N.; Hoermann, L.; Messerer, D.; Bartenstein, P.; Riemenschneider, M. J.; Lindner, S.; Ziegler, S.; Herms, J.; Lichtenthaler, S. F.; Ertürk, A.; Tonn, J. C.; von Baumgarten, L.; Albert, N. L.; Brendel, M.

10.1101/2023.01.26.522174 — neuroscience — Posted on 2023-01-29

310 Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia

Zhang, S.; Yi, S.; Wang, L.; Li, S.; Wang, H.; Song, L.; Ou, J.; Zhang, M.; Wang, R.; Wang, M.; Zheng, Y.; Yang, K.; Liu, T.; Ho, M.

10.1101/2021.08.16.456579 — neuroscience — Posted on 2023-01-29

311 A Versatile Deep Graph Contrastive Learning Framework for Single-cell Proteomics Embedding

Li, W.; Yang, F.; Wang, F.; Rong, Y.; Wu, B.; Zhang, H.; Yao, J.

10.1101/2022.12.14.520366 — bioinformatics — Posted on 2023-01-29

312 Pilot Analysis of Genetic Effects on Personality Test Scores with AI: ABO Blood Type in Japan

Kanazawa, M.

10.1101/2023.01.15.524099 — genetics — Posted on 2023-01-29

313 Regionalized protein localization domains in the hair cell kinocilium.

Erickson, T.; Biggers, W. P.; Williams, K.; Butland, S. E.; Venuto, A.

10.1101/2022.12.31.521896 — cell biology — Posted on 2023-01-29

314 Perturbation Variability Does Not Influence Implicit Sensorimotor Adaptation

Wang, T.; Avraham, G.; Tsay, J. S.; Abram, S. J.; Ivry, R. B.

10.1101/2023.01.27.525949 — neuroscience — Posted on 2023-01-29

315 TCGAnalyzeR: a web application for integrative visualization of molecular and clinical data of cancer patients for cohort and associated gene discovery

Zengin, T.; Abak Masud, B.; Onal-Suzek, T.

10.1101/2023.01.20.524925 — bioinformatics — Posted on 2023-01-29

316 Structural study of UFL1-UFC1 interaction uncovers the importance of UFL1 N-terminal helix for ufmylation

Banerjee, S.; Varga, J. K.; Kumar, M.; Zoltsman, G.; Isupov, M. N.; Rosenzweig, R.; Schueler-Furman, O.; Wiener, R.

10.1101/2022.09.15.508077 — biochemistry — Posted on 2023-01-29

317 Sex-dependent resource defense in a nectar-feeding bat

Wintergerst, S.; Winter, Y.; Nachev, V.

10.1101/2021.08.16.456451 — animal behavior and cognition — Posted on 2023-01-29

318 Hub connectivity in the human connectome: Links to aging and processing speed

Li, X.; Salami, A.; Persson, J.

10.1101/2023.01.28.525980 — neuroscience — Posted on 2023-01-29

319 Audiovisual integration is preserved in older adults across the cortical hierarchy

Jones, S. A.; Noppeney, U.

10.1101/2023.01.28.526027 — neuroscience — Posted on 2023-01-29

320 Single-Cell Transcriptome Dynamics of the Autotaxin-Lysophosphatidic Acid Axis During Muscle Regeneration Reveal Proliferative Effects in Mesenchymal Fibro-Adipogenic Progenitors

Contreras, O.; Harvey, R. P.

10.1101/2022.07.02.498539 — cell biology — Posted on 2023-01-29

321 The biology of aging in a social world: insights from free-ranging rhesus macaques

Newman, L.; Testard, C.; DeCasien, A. R.; Chiou, K. L.; Watowich, M. M.; Janiak, M. C.; Pavez-Fox, M. A.; Sanchez Rosado, M. R.; Cooper, E. B.; Costa, C. E.; Petersen, R. M.; Montague, M. M.; Platt, M. L.; Brent, L. J. N.; Snyder-Mackler, N.; Higham, J. P.

10.1101/2023.01.28.525893 — immunology — Posted on 2023-01-29

322 Humans adaptively select different computational strategies in different learning environments.

Verbeke, P.; Verguts, T.

10.1101/2023.01.27.525944 — neuroscience — Posted on 2023-01-29

323 Losses resulting from deliberate exploration trigger beta oscillations in frontal cortex

Chernyshev, B. V.; Pultsina, K. I.; Tretyakova, V. D.; Miasnikova, A. S.; Prokofyev, A. O.; Kozunova, G. L.; Stroganova, T. A.

10.1101/2022.10.06.510948 — neuroscience — Posted on 2023-01-29

324 POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia

Hong, Y.; Kristiansen, C. K.; Chen, A.; NIDO, G. S.; Hoyland, L. E.; Ziegler, M.; Sullivane, G. J.; Bindoff, L. A.; Liang, K. X.

10.1101/2023.01.28.526021 — neuroscience — Posted on 2023-01-29

325 Different time encoding strategies within the medial premotor areas of the primate

Merchant, H.; Mendoza, G.; Perez, O.; Betancourt, A.; Garcia-Saldivar, P.; Prado, L.

10.1101/2023.01.28.526038 — neuroscience — Posted on 2023-01-29

326 A scaling law relating the rate of destruction of a solid tumor and the fractal dimension of its boundary

Lopez, A. G.; Sanjuan, L. R.

10.1101/2022.06.29.498072 — cancer biology — Posted on 2023-01-28

327 Autoinhibited kinesin-1 adopts a hierarchical folding pattern

Tan, Z.; Yue, Y.; da Veiga Leprevost, F.; Haynes, S. E.; Basrur, V.; Nesvizhskii, A. I.; Verhey, K. J.; Cianfrocco, M. A.

10.1101/2023.01.26.525761 — biophysics — Posted on 2023-01-28

Hall, A. R.; Choi, Y. K.; Im, W.; Vavylonis, D.

10.1101/2023.01.27.525865 — biophysics — Posted on 2023-01-28

329 Conformationally responsive dyes enable protein-adaptive Differential Scanning Fluorometry

Wu, T.; Yu, J. C.; Suresh, A.; Gale-Day, Z. J.; Alteen, M. G.; Woo, A. S.; Millbern, Z.; Johnson, O. T.; Carroll, E. C.; Partch, C. L.; Fourches, D.; Vinueza, N. R.; Vocadlo, D. J.; Gestwicki, J. E.

10.1101/2023.01.23.525251 — biochemistry — Posted on 2023-01-28

330 KARS mediates intra-translational deposition of N6-acetyl-L-lysine in nascent proteins to contribute the acetylome in cells

Guo, D.; Zhang, X.; He, J.; Yu, W.; Zhou, R.; Tong, F.; Yin, S.; Wang, Y.; Yang, Y.; Xu, X.; Wang, L.; Fan, M.; Feng, S.; Hong, C.; Huang, C.; Liu, K.; Ouyang, Z.; Wang, Y.

10.1101/2023.01.08.523135 — biochemistry — Posted on 2023-01-28

331 Chromatin phase separated nanoregions regulated by cross-linkers and explored by single particle trajectories

Papale, A.; holcman, d.

10.1101/2022.12.16.520776 — genetics — Posted on 2023-01-28

332 A conserved, non-canonical insert in FIS1 is required for mitochondrial fission and recruitment of DRP1 and TBC1D15

Ihenacho, U. K.; Toro, R.; Mansour, R. H.; Hill, R. B.

10.1101/2023.01.24.525364 — cell biology — Posted on 2023-01-28

333 Soybean and cotton spermosphere soil microbiome shows dominance of soil-borne copiotrophs

Olofintila, O. E.; Noel, Z. A.

10.1101/2023.01.23.525219 — microbiology — Posted on 2023-01-28

334 Dichotomy in TCR V-domain dynamics binding the opposed inclined planes of pMHC-II and pMHC-I α-helices

Murray, J.

10.1101/2023.01.16.524284 — immunology — Posted on 2023-01-28

335 Increased neuron density in the midbrain of foveate birds results from profound change in tissue morphogenesis

Rodrigues, T.; Dib, L.; Brethaut, E.; Matter, M. M.; Matter-Sadzinski, L.; Matter, J.-M.

10.1101/2022.10.29.514341 — neuroscience — Posted on 2023-01-28

336 Sex-Specific Effects of Psychedelic Drug Exposure on Central Amygdala Reactivity and Behavioral Responding

Effinger, D. P.; Quadir, S. G.; Ramage, M. C.; Cone, M. G.; Herman, M. A.

10.1101/2022.04.28.489882 — neuroscience — Posted on 2023-01-28

337 Microscopic Imaging of Epigenetic Age

Rodriguez, D.; Alvarez-Kuglen, M.; Qin, H.; Fiengo, L.; Farhy, C.; Havas, A.; Hsu, W.-M.; Anderson, R. M.; Adams, P. D.; Sharpee, T. O.; Terskikh, A.

10.1101/2022.10.16.512441 — systems biology — Posted on 2023-01-28

338 A converged ubiquitin-proteasome pathway for the degradation of TOC and TOM tail-anchored receptors

Yang, M.; Chen, S.; Lim, S.-L.; Yang, L.; Zhong, J. Y.; Chan, K. C.; Zhao, Z.; Wong, K.-B.; Wang, J.; Lim, B. L.

10.1101/2023.01.07.523072 — plant biology — Posted on 2023-01-28

339 Two forms of sexual dimorphism in gene expression in Drosophila melanogaster: their coincidence and evolutionary genetics

Singh, A.; Agrawal, A. F.

10.1101/2021.02.08.429268 — evolutionary biology — Posted on 2023-01-28

340 Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes generation of the whole lung

Miura, A.; Sarmah, H.; Tanaka, J.; Hwang, Y.; Sawada, A.; Shimamura, Y.; Fang, Y.; Shimizu, D.; Ninish, Z.; Suer, J. L.; Dubois, N.; Davis, J.; Toyooka, S.; Wu, J.; Que, J.; Hawkins, F. J.; Lin, C.-S.; Mori, M.

10.1101/2022.10.31.514628 — developmental biology — Posted on 2023-01-28

341 Biflavonoid quercetin protects against cyclophosphamide induced organ toxicities via modulation of inflammatory cytokines, brain neurotransmitters, and astrocyte immunoreactivity

Onaolapo, A. Y.; Ojo, F. O.; Onaolapo, O. J.

10.1101/2023.01.27.525889 — pharmacology and toxicology — Posted on 2023-01-28

342 Investigating the impact of introduced crabs on the distribution and morphology of littorinid snails: Implications for the survival of the snail Littorina saxatilis

Wells, C. D.; Van Volkom, K. S.; Edquist, S.; Marovelli, S.; Marovelli, J.

10.1101/2023.01.28.526005 — ecology — Posted on 2023-01-28

343 Cup is essential for oskar mRNA translational repression during early Drosophila oogenesis

Bayer, L. V.; Milano, S. N.; Formel, S. K.; Kaur, H.; Ravichandran, R.; Cambeiro, J. A.; Slinko, L.; Catrina, I. E.; Bratu, D. P.

10.1101/2023.01.27.525950 — developmental biology — Posted on 2023-01-28

344 Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage C. elegans embryos

Gonczy, P.

10.1101/2023.01.27.525957 — developmental biology — Posted on 2023-01-28

345 The fission yeast methylphosphate capping enzyme Bmc1/Bin3 promotes 2'-O- methylation of U6 and pre-mRNA splicing

Porat, J.; Slat, V. A.; Rader, S. D.; Bayfield, M. A.

10.1101/2023.01.27.525755 — molecular biology — Posted on 2023-01-28

346 Structural characterization of HIV-1 Env heterotrimers bound to one or two CD4 receptors reveals intermediate Env conformations

Dam, K.-M. A.; Fan, C.; Yang, Z.; Bjorkman, P. J.

10.1101/2023.01.27.525985 — molecular biology — Posted on 2023-01-28

347 Vitamin interdependencies predicted by metagenomics-informed network analyses validated in microbial community microcosms

Hessler, T.; Huddy, R. J.; Sachdeva, R.; Lei, S.; Harrison, S. T. L.; Diamond, S.; Banfield, J. F.

10.1101/2023.01.27.524772 — microbiology — Posted on 2023-01-28

348 Iron Regulatory Protein 1 is Required for the Propagation of Inflammation in Inflammatory Bowel Disease

Fahoum, L.; Belizowsky, S.; Ghatpande, N.; Guttmann-Raviv, N.; Zhang, W.; Kuanyu, L.; Wing-Hang, T.; Nyska, A.; Waterman, M.; Weisshof, R.; Zukirman, A.; Meyron-Holtz, E.

10.1101/2023.01.27.525690 — immunology — Posted on 2023-01-28

349 Protein aggregation in wound fluid confines bacterial lipopolysaccharide and reduces inflammation

Petrlova, J.; Hartman, E.; Petruk, G.; Lim, J. C. H.; Adav, S. S.; Kjellstrom, S.; Puthia, M.; Schmidtchen, A.

10.1101/2023.01.27.525825 — immunology — Posted on 2023-01-28

350 Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness

Eggert, J.; Zinzow-Kramer, W.; Hu, Y.; Tsai, Y.-L.; Weiss, A.; Salaita, K.; Scharer, C.; Au-Yeung, B. B.

10.1101/2023.01.27.525946 — immunology — Posted on 2023-01-28

351 Anteromedial Thalamus Gates the Selection & Stabilization of Long-Term Memories

Toader, A. C.; Regalado, J. M.; Li, Y. R.; Terceros, A.; Yadav, N.; Kumar, S.; Satow, S.; Hollunder, F.; Bonito-Oliva, A.; Rajasethupathy, P.

10.1101/2023.01.27.525908 — neuroscience — Posted on 2023-01-28

352 Cleo: a testbed for bridging model and experiment by simulating closed-loop stimulation, electrode recording, and optogenetics

Johnsen, K. A.; Cruzado, N. A.; Willats, A. A.; Rozell, C. J.

10.1101/2023.01.27.525963 — neuroscience — Posted on 2023-01-28

353 pA regulator: a system for controlling mammalian gene expression via the modulation of polyA signal cleavage

Luo, L.; Jea, J. D.-Y.; Wang, Y.; Chao, P.-W.; Yen, L.

10.1101/2023.01.27.525935 — synthetic biology — Posted on 2023-01-28

354 Natural variation in salt-induced root growth phases and their contribution to root architecture plasticity

van Zelm, E.; Bugallo-Alfageme, S.; Behrouzi, P.; Meyer, J.; Testerink, C.; Gommers, C. M. M.

10.1101/2023.01.27.525841 — plant biology — Posted on 2023-01-28

355 Social Isolation Causes Cortical and Trabecular Bone Loss in Adult Male, but not Female, C57BL/6J Mice

Mountain, R. V.; Langlais, A. L.; Hu, D.; Baron, R.; Lary, C. W.; Motyl, K. J.

10.1101/2023.01.27.525939 — physiology — Posted on 2023-01-28

356 Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts

Rodriguez-Hernandez, D.; Vijayan, K.; Zigweid, R.; Fenwick, M. K.; Sankaran, B.; Roobsoong, W.; Sattabongkot, J.; Glennon, E. K. K.; Myler, P. J.; Sunnerhagen, P.; Staker, B. L.; Kaushansky, A.; Grotli, M.

10.1101/2023.01.27.525941 — pharmacology and toxicology — Posted on 2023-01-28

357 Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

Braxton, A. M.; Kiemen, A. L.; Grahn, M. P.; Forjaz, A.; Babu, J. M.; Zheng, L.; Jiang, L.; Cheng, H.; Song, Q.; Reichel, R.; Graham, S.; Damanakis, A. I.; Fischer, C. G.; Mou, S.; Metz, C.; Granger, J.; Liu, X.-D.; Bachmann, N.; Almagro-Perez, C.; Jiang, A. C.; Yoo, J.; Kim, B.; Du, S.; Foster, E.; Hsu, J. Y.; Rivera, P. A.; Chu, L. C.; Liu, F.; Niknafs, N.; Fishman, E.; Yuille, A.; Roberts, N. J.; Thompson, E. D.; Scharpf, R. B.; Cornish, T. C.; Jiao, Y.; Karchin, R.; Hruban, R. H.; Wu, P.-H.; Wirtz, D.; Wood, L. D.

10.1101/2023.01.27.525553 — cancer biology — Posted on 2023-01-28

358 MIIP downregulation promotes colorectal cancer progression via inducing adjacent adipocytes browning

Qinhao, W.; Yuanyuan, S.; Ruiqi, S.; Xin, X.; Kai, G.; Wei, M.; Yi, R.; Guodong, Y.; Zhengxiang, Z.; Qing, Q.; Xia, L.

10.1101/2023.01.28.526013 — cancer biology — Posted on 2023-01-28

359 In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies

Sealover, N. E.; Theard, P. T.; Linke, A. J.; Hughes, J. M.; Daley, B. R.; Kortum, R. L.

10.1101/2023.01.27.525958 — cancer biology — Posted on 2023-01-28

360 Role of Strong Localized vs. Weak Distributed Interactions in Disordered Protein Phase Separation

Rekhi, S.; Sundaravadivelu Devarajan, D.; Howard, M. P.; Kim, Y. C.; Nikoubashman, A.; Mittal, J.

10.1101/2023.01.27.525976 — biophysics — Posted on 2023-01-28

361 Efficient image analysis for large-scale next generation histopathology using pAPRica

Scholler, J.; Jonsson, J.; Jorda-Siquier, T.; Gantar, I.; Batti, L.; Cheeseman, B.; Pages, S.; Sbalzarini, I. F.; Lamy, C. M.

10.1101/2023.01.27.525687 — bioinformatics — Posted on 2023-01-28

362 A quantitative approach to measure and predict microbiome response to antibiotics

Tu, V.; Ren, Y.; Tanes, C.; Mukhopadhyay, S.; Daniel, S. G.; Li, H.; Bittinger, K.

10.1101/2023.01.27.525904 — bioinformatics — Posted on 2023-01-28

363 Measuring and Modeling Macrophage Growth using a Lab-on-CMOS Capacitance Sensing Microsystem

Smith, K.; Lin, C.-Y.; Gilpin, Y.; Wayne, E. C.; Dandin, M.

10.1101/2023.01.27.525955 — bioengineering — Posted on 2023-01-28

364 Large polyacrylamide hydrogels for large-batch cell culture and mechanobiological studies

Shi, X.; Janmey, P.

10.1101/2023.01.27.525967 — bioengineering — Posted on 2023-01-28

365 Rapid genome functional annotation pipeline anchored to the House sparrow (Passer domesticus, Linnaeus 1758) genome reannotation

Magallanes-Alba, M. E.; Baricalla, A.; Rego, N.; Brun, A.; Karasov, W. H.; Caviedes-Vidal, E.

10.1101/2023.01.27.525869 — genomics — Posted on 2023-01-28

366 The aftermath of a trophic cascade: Increasedanoxia following species invasion of a eutrophiclake

Rohwer, R. R.; Ladwig, R.; Dugan, H. A.; Hanson, P. C.; Walsh, J. R.; Vander Zanden, M. J.

10.1101/2023.01.27.525925 — ecology — Posted on 2023-01-28

367 RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils

Zezulin, A. U.; Ye, D.; Howell, E.; Yen, D.; Bresciani, E.; Diemer, J.; Ren, J.-g.; Ahmad, M. H.; Castilla, L. H.; Touw, I. P.; Minn, A. J.; Tong, W.; Liu, P. P.; Tan, K.; Yu, W.; Speck, N. A.

10.1101/2023.01.27.525911 — developmental biology — Posted on 2023-01-28

368 ChIP-MS reveals the local chromatin composition by label-free quantitative proteomics

Yong, W. K.; Rane, G.; Zaal Anuar, N.; Shao, X.; Goh, C. Y.; Khanchandani, V.; Kuan, V. L. S.; Jeitany, M.; Koeffler, P.; Deng, L.-W.; Sanda, T.; Kappei, D.

10.1101/2023.01.27.525999 — biochemistry — Posted on 2023-01-28

369 Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion

Purcell, R. H.; Sefik, E.; Werner, E.; King, A. T.; Mosley, T. J.; Merritt-Garza, M. E.; Chopra, P.; McEachin, Z. T.; Karne, S.; Raj, N.; Tilahun, K.; Robinette, M.; Warren, S. T.; Wen, Z.; Faundez, V.; Sloan, S. A.; Bassell, G. J.; Mulle, J. G.

10.1101/2023.01.27.525748 — genomics — Posted on 2023-01-28

370 Joint tensor modeling of single cell 3D genome and epigenetic data with Muscle

Park, K.; Keles, S.

10.1101/2023.01.27.525871 — genomics — Posted on 2023-01-28

371 Lateral gene transfer leaves lasting traces in Rhizaria

van Hooff, J. J. E.; Eme, L.

10.1101/2023.01.27.525846 — evolutionary biology — Posted on 2023-01-28

372 Essential resource provision can enhance persistence in food webs

Raatz, M.

10.1101/2023.01.27.525839 — ecology — Posted on 2023-01-28

373 Nhsl1b regulates mesodermal cell migration by controlling protrusion dynamics during zebrafish gastrulation.

Escot, S.; Elouin, A.; Mellottee, L.; David, N. B.

10.1101/2023.01.28.526006 — cell biology — Posted on 2023-01-28

374 Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitors

Le Rouzic, E.; Bonnard, D.; Le Strat, F.; Batisse, C.; Batisse, J.; Amadori, C.; Chasset, S.; Emiliani, S.; Ledoussal, B.; Ruff, M.; Moreau, F.; Benarous, R.

10.1101/2023.01.28.523533 — microbiology — Posted on 2023-01-28

375 Complexity of spatiotemporal plantar pressure patterns during everyday behaviours

Cleland, L. D.; Rowland, H. M.; Mazza, C.; Saal, H. P.

10.1101/2023.01.27.525870 — neuroscience — Posted on 2023-01-28

376 Power Series Template Matching Model for Pitch Perception

Takahashi, J.-i.

10.1101/2023.01.27.525831 — neuroscience — Posted on 2023-01-28

377 Exploring Replay

Antonov, G.; Dayan, P.

10.1101/2023.01.27.525847 — neuroscience — Posted on 2023-01-28

378 Heterogeneity in quiescent Müller glia in the uninjured zebrafish retina drive differential responses following photoreceptor ablation

Krylov, A. J.; Yu, S.; Newton, A. H.; He, j.; Jusuf, P. R.

10.1101/2023.01.27.525802 — neuroscience — Posted on 2023-01-28

379 Prefrontal Cortex Encodes Value Pop-out in Visual Search

Abbaszadeh, M.; Panjehpour, A.; Alemohammad, S. M. A.; Ghavampour, A.; Ghazizadeh, A.

10.1101/2023.01.27.525832 — neuroscience — Posted on 2023-01-28

380 Pleistocene dispersion supports a unique native diversity in the Colombian avocado germplasm

Berdugo-Cely, J. A.; Cortes, A.; Lopez-Hernandez, F.; Delgadillo-Duran, P.; Ceron-Souza, I.; Reyes-Herrera, P. H.; Navas, A.; Yockteng, R.

10.1101/2023.01.27.525883 — plant biology — Posted on 2023-01-28

381 FRETpredict: A Python package for FRET efficiency predictions using rotamer libraries

Montepietra, D.; Tesei, G.; Martins, J. M.; Kunze, M. B. A.; Best, R.; Lindorff-Larsen, K.

10.1101/2023.01.27.525885 — biophysics — Posted on 2023-01-28

382 Complexity of Guanine Quadruplex Unfolding Pathways Revealed by Atomistic Pulling Simulations

Stadlbauer, P.; Mlynsky, V.; Krepl, M.; Sponer, J.

10.1101/2023.01.27.525972 — biophysics — Posted on 2023-01-28

383 Early HIV-1 Gag Assembly on Lipid Membrane with vRNA

Zhou, A. X.-Z.; Hammond, J. A.; Sheng, K.; Millar, D. P.; Williamson, J. R.

10.1101/2023.01.27.525415 — biophysics — Posted on 2023-01-28

384 Efficient estimation of breakpoints in piecewise-linear mixed-effects models for longitudinal ophthalmic studies

Lee, T.; Schuman, J.; Ramos Cadena, M. d. l. A.; Zhang, Y.; Wollstein, G.; Hu, J.

10.1101/2023.01.27.525884 — bioinformatics — Posted on 2023-01-28

385 DeepERA: deep learning enables comprehensive identification of drug-target interactions via embedding of heterogeneous data

Li, L.; Wierbowski, S. D.; Yu, H.

10.1101/2023.01.27.525827 — bioinformatics — Posted on 2023-01-28

386 HAT: de novo variant calling for highly accurate short-read and long-read sequencing data

Ng, J. K.; Turner, T. N.

10.1101/2023.01.27.525940 — bioinformatics — Posted on 2023-01-28

387 scGREAT: Graph-based regulatory element analysis tool for single-cell multi-omics data

Liu, C.; Wang, L.; Liu, Z.

10.1101/2023.01.27.525916 — bioinformatics — Posted on 2023-01-28

388 The nuclear receptor LRH-1 discriminates between ligands using distinct allosteric signaling circuits

Mays, S.; Hercules, D.; Ortlund, e.; Okafor, C. D.

10.1101/2023.01.27.525934 — biochemistry — Posted on 2023-01-28

389 Structure and dynamics of the essential endogenous mycobacterial polyketide synthasePks13

Kim, S. K.; Dickinson, M. S.; Finer-Moore, J. S.; Guan, Z.; Kaake, R. M.; Echeverria, I.; Chen, J.; Pulido, E. H.; Sali, A.; Krogan, N. J.; Rosenberg, O. S.; Stroud, R. M.

10.1101/2023.01.27.525930 — biochemistry — Posted on 2023-01-28

390 Phylogenetics and phylogeography of Euphorbia canariensis reveal an extreme Canarian-Asian disjunction and limited inter-island colonization

Coello, A. J.; Vargas, P.; Cano, E.; Riina, R.; Fernandez-Mazuecos, M.

10.1101/2023.01.27.525850 — evolutionary biology — Posted on 2023-01-28

391 Long-term herbivore removal experiments reveal different impacts of geese and reindeer on vegetation and ecosystem CO2-fluxes in high-Arctic tundra

Petit Bon, M.; Hansen, B. B.; Loonen, M. J. J. E.; Petraglia, A.; Brathen, K. A.; Bohner, H.; Layton-Matthews, K.; Beard, K. H.; Le Moullec, M.; Jonsdottir, I. S.; Van der Wal, R.

10.1101/2023.01.27.525821 — ecology — Posted on 2023-01-28

392 Nesting flight statistics for wind turbine planning: a MoveApps workflow

Koelzsch, A.; Gal, J.

10.1101/2023.01.27.525824 — ecology — Posted on 2023-01-28

393 Early life exposure to broccoli sprouts confers stronger protection against enterocolitis development in an immunological mouse model of inflammatory bowel disease.

Holcomb, L.; Holman, J. M.; Hurd, M.; Lavoie, B.; Colucci, L.; Hunt, B.; Hunt, T.; Mawe, G. M.; Moses, P. L.; Perry, E.; Stratigakis, A.; Zhang, T.; Chen, G.; Ishaq, S. L.; Li, Y.

10.1101/2023.01.27.525953 — microbiology — Posted on 2023-01-28

394 Mass cytometry identifies dysregulation of circulating and cutaneous immune cells in patients with hidradenitis suppurativa

Dimitrion, P.; Hamzavi, I.; Yin, C.; Loveless, I.; Toor, J.; Subedi, K.; Khalasawi, N.; Miller, A.; Huggins, R.; Adrianto, I.; Veenstra, J.; Vellaichamy, G.; Hans, A.; Daveluy, S.; Athar, M.; Liao, W.; Lim, H.; Ozog, D.; Zhou, L.; Mi, Q.-S.

10.1101/2023.01.27.525867 — immunology — Posted on 2023-01-28

395 Memory reactivation of real-world spatial orientation revealed by human electrophysiology.

Schreiner, T.; Griffiths, B. J.; Kutlu, M.; Vollmar, C.; Kaufmann, E.; Quach, S.; Remi, J.; Noachtar, S.; Staudigl, T.

10.1101/2023.01.27.525854 — neuroscience — Posted on 2023-01-28

396 Overlap in the cortical representation of hand and forearm muscles as assessed by navigated TMS

Jin, F.; Bruijn, S. M.; Daffertshofer, A.

10.1101/2023.01.27.525857 — neuroscience — Posted on 2023-01-28

397 Different time scales of common-cause evidence shape multisensory integration, recalibration and motor adaptation

Debats, N.; Heuer, H.; Kayser, C.

10.1101/2023.01.27.525820 — neuroscience — Posted on 2023-01-28

398 Two conserved vocal central pattern generators broadly tuned for fast and slow rates generate species-specific vocalizations in Xenopus clawed frogs

Yamaguchi, A.; Peltier, M.

10.1101/2023.01.27.525835 — neuroscience — Posted on 2023-01-28

399 Elucidating Fibroblast Growth Factor-induced kinome dynamics using targeted mass spectrometry and dynamic modeling

Veth, T. S.; Heck, A. J. R.; Francavilla, C.; Altelaar, M.

10.1101/2023.01.27.525819 — systems biology — Posted on 2023-01-28

400 Carotenoid retention during post-harvest storage of Capsicum annuum: the role of the fruit surface structure.

Holden, A. C.; Cohen, H.; Rickett, D. V.; Aharoni, A.; Fraser, P. D.

10.1101/2023.01.27.525890 — plant biology — Posted on 2023-01-28

401 Heat dissipation from photosynthesis contributes to maize thermoregulation under suboptimal temperature conditions

Sobejano-Paz, V.; Mo, X.; Liu, S.; Mikkelsen, T. N.; He, L.; Jin, H.; Garcia, M.

10.1101/2023.01.27.525868 — plant biology — Posted on 2023-01-28

402 Synthetic lethality in large-scale integrated metabolic and regulatory network models of human cells

Barrena, N.; Valcarcel, L.; Olaverri-Mendizabal, D.; Apaolaza, I.; Planes, F. J.

10.1101/2023.01.27.525829 — cancer biology — Posted on 2023-01-28

403 Conformational stability of a peroxidase from Artocarpus lakoocha: Effect of pH, chaotrophs and temperature.

Sonkar, K. S.; Pachauri, M.; Kumar, A.; Medicherla, J.

10.1101/2023.01.27.525866 — biophysics — Posted on 2023-01-28

404 N-of-one differential gene expression without control samples using a deep generative model

Prada-Luengo, I.; Schuster, V.; Liang, Y.; Terkelsen, T.; Sora, V.; Krogh, A.

10.1101/2023.01.27.525843 — bioinformatics — Posted on 2023-01-28

405 Sexually Dimorphic Role for Insular Perineuronal Nets in Aversion-Resistant Ethanol Consumption

Carvalho, L. M.; Chen, H.; Sutter, M.; Lasek, A. W.

10.1101/2023.01.27.525899 — animal behavior and cognition — Posted on 2023-01-28

406 AIRRSHIP: simulating human B cell receptor repertoire sequences

Sutherland, C.; Cowan, G. J. M.

10.1101/2022.12.20.521228 — bioinformatics — Posted on 2023-01-28

407 Targeted volume Correlative Light and Electron Microscopy of an environmental marine microorganism

Mocaer, K.; Mizzon, G.; Gunkel, M.; Halavatyi, A.; Steyer, A. M.; Oorschot, V.; Schorb, M.; Le Kieffre, C.; Yee, D. P.; Chevalier, F.; Gallet, B.; Decelle, J.; Schwab, Y.; Ronchi, P.

10.1101/2023.01.27.525698 — cell biology — Posted on 2023-01-28

408 The Autophagy Receptor NBR1 Directs the Clearance of Photodamaged Chloroplasts

Lee, H.-N.; V Chacko, J.; Gonzalez Solis, A.; Chen, K.-E.; Barros, J. A. S.; Signorelli, S.; Havey Millar, A.; Vierstra, R. D.; Eliceiri, K. W.; Otegui, M. S.

10.1101/2023.01.27.525901 — cell biology — Posted on 2023-01-28

409 Assessing functional connectivity differences and work-related fatigue in surviving COVID-negative patients.

Hafiz, R.; Gandhi, T. K.; Misrhra, S.; Prasad, A.; Mahajan, V.; Natelson, B.; Di, X.; Biswal, B.

10.1101/2022.02.01.478677 — neuroscience — Posted on 2023-01-28

410 BRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation.

Witus, S. R.; Tuttle, L. M.; Li, W.; Zelter, A.; Wang, M.; Kermoade, K. E.; Wilburn, D. B.; Davis, T. N.; Brzovic, P.; Zhao, W.; Klevit, R. E.

10.1101/2022.08.09.503292 — biochemistry — Posted on 2023-01-28

411 Design of stimulus-responsive two-state hinge proteins

Praetorius, F.; Leung, P. J. Y.; Tessmer, M. H.; Broerman, A.; Demakis, C.; Dishman, A. F.; Pillai, A.; Idris, A.; Juergens, D.; Dauparas, J.; Li, X.; Levine, P. M.; Lamb, M.; Ballard, R. K.; Gerben, S. R.; Nguyen, H.; Kang, A.; Sankaran, B.; Bera, A. K.; Volkman, B. F.; Nivala, J.; Stoll, S.; Baker, D.

10.1101/2023.01.27.525968 — biophysics — Posted on 2023-01-28

412 Counterintuitive Binding of Phosphorylated DEP Domain from Dishevelled Protein to Negatively Charged Membranes

Falginella, F. L.; Drabinova, M.; Bryja, V.; Vacha, R.

10.1101/2023.01.27.525887 — biophysics — Posted on 2023-01-28

413 Dimerization mechanism of an inverted-topology ion channel in membranes

Ernst, M.; Orabi, E. A.; Stockbridge, R. B.; Faraldo-Gomez, J. D.; Robertson, J. L.

10.1101/2023.01.27.525942 — biophysics — Posted on 2023-01-28

414 Haploid androgenetic development in bovines reveals imbalanced WNT signaling and impaired cell fate differentiation.

Aguila, L.; Nociti, R. P.; Sampaio, R. V.; Therrien, J.; Meirelles, F. V.; Felmer, R. N.; Smith, L. C.

10.1101/2023.01.27.525928 — developmental biology — Posted on 2023-01-28

415 An adult stem-like cell population generates germline and neurons in the sea anemone Nematostella vectensis

Miramon-Puertolas, P.; Steinmetz, P. R. H.

10.1101/2023.01.27.525880 — developmental biology — Posted on 2023-01-28

416 scMultiome analysis identifies embryonic hindbrain progenitors with mixed rhombomere identities

Kim, Y.-I.; O'Rourke, R.; Sagerstrom, C. G.

10.1101/2023.01.27.525932 — developmental biology — Posted on 2023-01-28

417 Quantifying single cell lipid signaling kinetics after photo-stimulation

Gonzales, D. T.; Schuhmacher, M.; Lennartz, H. M.; Iglesias-Artola, J. M.; Kuhn, S. M.; Barahtjan, P.; Zechner, C.; Nadler, A.

10.1101/2023.01.27.525833 — cell biology — Posted on 2023-01-28

418 Redefining hematopoietic progenitors cells and reaffirming lineage commitment by transcriptional atlas

Yue, Y.

10.1101/2023.01.27.524347 — cell biology — Posted on 2023-01-28

419 Functional Optimization of Light-Activatable Opto-GPCRs: Illuminating the Importance of the Proximal C-terminus in G-protein Specificity

Leemann, S.; Kleinlogel, S.

10.1101/2023.01.27.525823 — cell biology — Posted on 2023-01-28

420 A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells

Kinghorn, K.; Gill, A.; Marvin, A.; Li, R.; Quigley, K.; le Noble, F.; Mac Gabhann, F.; Bautch, V. L.

10.1101/2023.01.27.525517 — cell biology — Posted on 2023-01-28

421 Extracellular vesicles and co-isolated endogenous retroviruses differently affect dendritic cells

Cocozza, F.; martin jaular, l.; lippens, l.; di cicco, a.; arribas, y. a.; dingli, f.; richard, m.; merle, l.; Poullet, P.; loew, d.; Hendrix, A.; Kassiotis, G.; joliot, a.; tkach, m.; Thery, C.

10.1101/2023.01.27.525863 — cell biology — Posted on 2023-01-28

422 Dandelion utilizes single cell adaptive immune receptor repertoire to explore lymphocyte developmental origins

Suo, C.; Polanski, K.; Dann, E.; Lindeboom, R. G. H.; Vilarrasa Blasi, R.; Vento-Tormo, R.; Haniffa, M.; Meyer, K. B.; Dratva, L. M.; Tuong, Z. K.; Clatworthy, M. R.; Teichmann, S.

10.1101/2022.11.18.517068 — immunology — Posted on 2023-01-27

423 Molecular basis of RanGTP-activated nucleosome assembly with Histones H2A-H2B bound to Importin-9

Shaffer, J. M.; Jiou, J.; Tripathi, K.; Olaluwoye, O. S.; Fung, H. Y. J.; Chook, Y. M.; D'Arcy, S.

10.1101/2023.01.27.525896 — biophysics — Posted on 2023-01-28

424 Cryo-EM structure of the polyphosphate polymerase VTC: Coupling polymer synthesis to membrane transit

Ye, S.

10.1101/2023.01.27.525886 — biophysics — Posted on 2023-01-28

425 Newly born mesenchymal cells disperse through a rapid mechanosensitive migration

Riddell, J.; Noureen, S. R.; Sedda, L.; Glover, J. D.; Ho, W. K. W.; Bain, C. A.; Berbeglia, A.; Brown, H.; Anderson, C.; Chen, Y.; Crichton, M. L.; Yates, C. A.; Mort, R. L.; Headon, D. J.

10.1101/2023.01.27.525849 — cell biology — Posted on 2023-01-28

426 Dendritic spine neck plasticity controls synaptic expression of long-term potentiation

Gupta, R.; O'Donnell, C.

10.1101/2023.01.27.525952 — neuroscience — Posted on 2023-01-27

427 Eomes restricts Brachyury functions at the onset of mammalian gastrulation

Schüle, K. M.; Weckerle, J.; Probst, S.; Wehmeyer, A. E.; Zissel, L.; Schröder, C. M.; Tekman, M.; Kim, G.-J.; Schlägl, I.-M.; Sagar, ; Arnold, S. J.

10.1101/2023.01.27.525830 — developmental biology — Posted on 2023-01-27

428 eIF2B localisation and its regulation during the integrated stress response is cell type specific

Hanson, F. M.; Ribeiro de Oliveira, M. I.; Cross, A. K.; Allen, K. E.; Campbell, S. G.

10.1101/2023.01.10.523470 — cell biology — Posted on 2023-01-27

429 Remapping in a recurrent neural network model of navigation and context inference

Low, I. I.; Giocomo, L. M.; Williams, A. H.

10.1101/2023.01.25.525596 — neuroscience — Posted on 2023-01-27

430 Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell

Wang, Y.; Arnold, M. L.; Smart, A. J.; Wang, G.; Androwski, R. J.; Morera, A.; Nguyen, K. C.; Schweinsberg, P. J.; Bai, G.; Cooper, J.; Hall, D. H.; Driscoll, M.; Grant, B.

10.1101/2022.07.31.502194 — neuroscience — Posted on 2023-01-27

431 The proteomic landscape of synaptic diversity across brain regions and cell types

van Oostrum, M.; Blok, T.; Giandomenico, S. L.; tom Dieck, S.; Tushev, G.; Fuerst, N.; Langer, J. D.; Schuman, E. M.

10.1101/2023.01.27.525780 — neuroscience — Posted on 2023-01-27

432 Elevated Glucocorticoid alters the trajectory of hypothalamic development and function

Eachus, H.; Choi, M. K.; Tochwin, A.; Kaspareit, J.; Ho, M.; Ryu, S.

10.1101/2023.01.27.525966 — neuroscience — Posted on 2023-01-27

433 Engineering synthetic CopT/A-based genetic circuits for miRNA imaging and functional gene regulation

Zhang, C.; Shi, X.; Tang, C.; Du, Y.; Shu, W.; Wang, F.

10.1101/2023.01.25.525516 — synthetic biology — Posted on 2023-01-27

434 Analysis of National Institutes of Health Grant K99 to R00 Transitions from 2007 to 2022

Tyrrell, D. J.

10.1101/2023.01.26.525751 — scientific communication and education — Posted on 2023-01-27

435 Effect of mitochondrial circulation on mitochondrial age density distribution

Kuznetsov, I. A.; Kuznetsov, A. V.

10.1101/2022.12.01.518783 — biophysics — Posted on 2023-01-27

436 On the origin of the integrity of a subset of Topologically Associating Domains upon Cohesin loss in Interphase Chromosomes

JEONG, D.; Shi, G.; Li, X.; Thirumalai, D.

10.1101/2022.10.22.513342 — biophysics — Posted on 2023-01-27

437 Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity

Yun, S.; Soler, I.; Tran, F. H.; Haas, H. A.; Shi, R.; Bancroft, G. L.; Suarez, M.; de Santis, C. R.; Raynolds, R. P.; Eisch, A. J.

10.1101/2023.01.26.525756 — animal behavior and cognition — Posted on 2023-01-27

438 Quantifying constraint in the human mitochondrial genome

Lake, N. J.; Liu, W.; Battle, S. L.; Laricchia, K. M.; Tiao, G.; Puiu, D.; Compton, A. G.; Cowie, S.; Christodoulou, J.; Thorburn, D. R.; Zhao, H.; Arking, D. E.; Sunyaev, S. R.; Lek, M.

10.1101/2022.12.16.520778 — genetics — Posted on 2023-01-27

439 Quantifying the adaptive landscape of commensal gut bacteria using high-resolution lineage tracking

Wong, D. P. G. H.; Good, B. H.

10.1101/2022.05.13.491573 — evolutionary biology — Posted on 2023-01-27

440 Genes vary greatly in their propensity for collateral fitness effects of mutations

Mehlhoff, J. D.; Ostermeier, M.

10.1101/2022.10.24.513589 — evolutionary biology — Posted on 2023-01-27

441 Bayesian modeling of the impact of antibiotic resistance on the efficiency of MRSA decolonization

Ojala, F.; Sater, M. R. A.; Miller, L. G.; McKinnell, J. A.; Huang, S. S.; Grad, Y. H.; Marttinen, P.

10.1101/2023.01.25.525621 — microbiology — Posted on 2023-01-27

442 The infectious salmon anaemia virus esterase prunes erythrocyte surfaces in infected Atlantic salmon and exposes terminal sialic acids to lectin recognition

Fosse, J. H.; Andresen, A. M. S.; Ploss, F. B.; Weli, S. C.; Heffernan, I.; Sapotka, S.; Lundgard, K.; Kuiper, R. V.; Solhaug, A.; Falk, K.

10.1101/2023.01.25.525626 — microbiology — Posted on 2023-01-27

443 Transcranial magnetic stimulation to frontal but not occipital cortex disrupts endogenous attention

Fernandez, A.; Hanning, N. M.; Carrasco, M.

10.1101/2022.11.01.514715 — neuroscience — Posted on 2023-01-27

444 From recency to central tendency biases in working memory: a unifying network model

Boboeva, V.; Pezzotta, A.; Clopath, C.; Akrami, A.

10.1101/2022.05.16.491352 — neuroscience — Posted on 2023-01-27

445 Multiplex qPCR assays for detection of two imperiled anuran species, Anaxyrus californicus and Spea hammondii, from environmental DNA

Rodgers, T. W.; Lovich, R. E.; Walton, J. A.; Prince, D. J.; Gonzalez, B. R.; Shaffer, H. B.; Mock, K. E.

10.1101/2022.12.20.521282 — zoology — Posted on 2023-01-27

446 Evidence for an RNAi-independent role of DICER-LIKE2 in conferring growth inhibition and basal antiviral resistance

Nielsen, C. P. S.; Arribas-Hernandez, L.; Han, L.; Andersen, S. U.; Pumplin, N.; Brodersen, P.

10.1101/2023.01.10.523401 — plant biology — Posted on 2023-01-27

447 In silico Antibody-Peptide Epitope prediction for Personalized cancer therapy

Jacobs, I.; Lim, C. M.; Emmanoil, M.; Malik, N.

10.1101/2023.01.23.525181 — cancer biology — Posted on 2023-01-27

448 Ligand Binding Free Energy Evaluation by Monte Carlo Recursion

de Souza, J. V.; Nogueira, V. H. R.; Nascimento, A. S.

10.1101/2022.08.01.502202 — biophysics — Posted on 2023-01-27

449 Emergent complexity in slowly driven stochastic processes

Costa, A. C.; Vergassola, M.

10.1101/2023.01.03.522580 — biophysics — Posted on 2023-01-27

450 An environmentally ultrasensitive fluorine probe to resolve protein conformational ensembles by 19F NMR and cryo-EM

Huang, Y.; Reddy, K. D.; Bracken, C.; Qiu, B.; Zhan, W.; Eliezer, D.; Boudker, O.

10.1101/2022.03.29.486269 — biophysics — Posted on 2023-01-27

451 Strong positive allometry of bite force in leaf-cutter ants increases the range of cuttable plant tissues

Pueffel, F.; Roces, F.; Labonte, D.

10.1101/2022.09.28.509980 — biophysics — Posted on 2023-01-27

452 Activation Mechanism of the Human Smoothened Receptor

Bansal, P.; Dutta, S.; Shukla, D.

10.1101/2022.06.07.493647 — biophysics — Posted on 2023-01-27

453 OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems

Mendonca, T.; Lis-Slimak, K.; Matheson, A. B.; Smith, M. G.; Anane-Adjei, A. B.; Ashworth, J. C.; Cavanagh, R.; Paterson, L.; Dalgarno, P. A.; Alexander, C.; Tassieri, M.; Merry, C. L. R.; Wright, A. J.

10.1101/2022.04.21.489042 — bioengineering — Posted on 2023-01-27

454 Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice

Macip, C. C.; Hasan, R.; Hoznek, V.; Kim, J.; Metzger, L. E.; Sethna, S.; Davidsohn, N.

10.1101/2023.01.04.522507 — bioengineering — Posted on 2023-01-27

455 Contribution of circulating host and microbial tryptophan metabolites towards Ah receptor activation

Morgan, E. W.; Dong, F.; Annalora, A.; Murray, I. A.; Wolfe, T.; Erickson, R.; Gowda, K.; Amin, S. G.; Petersen, K. S.; Kris-Etherton, P. M.; Marcus, C.; Walk, S. T.; Patterson, A. D.; Perdew, G. H.

10.1101/2023.01.26.525691 — biochemistry — Posted on 2023-01-27

456 Visual versus visual-inertial guidance in hawks pursuing terrestrial targets

Kempton, J. A.; Brighton, C. H.; France, L. A.; Klein Heerenbrink, M.; Minano, S.; Shelton, J.; Taylor, G. K.

10.1101/2022.12.24.521635 — animal behavior and cognition — Posted on 2023-01-27

457 Chronic Gq activation of ventral hippocampal neurons and astrocytes differentially affects memory and behavior

Suthard, R. L.; Jellinger, A. L.; Shpokayte, M.; Surets, M.; Pyo, A. Y.; Buzharsky, M. D.; Senne, R. A.; Dorst, K.; LeBlanc, H.; Ramirez, S.

10.1101/2022.09.15.508157 — animal behavior and cognition — Posted on 2023-01-27

458 Predicting the functional effect of compound heterozygous genotypes from large scale variant effect maps

Xie, M. J.; Cromie, G. A.; Owens, K.; Timour, M. S.; Tang, M.; Kutz, J. N.; El-Hattab, A. W.; McLaughlin, R. N.; Dudley, A.

10.1101/2023.01.11.523651 — genetics — Posted on 2023-01-27

459 Exploring genome gene content and morphological analysis to test recalcitrant nodes in the animal phylogeny

Juravel, K.; Porras, L.; Hoehna, S.; Pisani, D.; Wörheide, G.

10.1101/2021.11.19.469253 — evolutionary biology — Posted on 2023-01-27

460 Mutation of gabra1 is associated with hypermotility and abnormal expression of proteins critical for ion homeostasis and synaptic vesicle transport.

Reyes-Nava, N. G.; Perez, I.; Grajeda, B.; Estevao, I. L.; Ellis, C. C.; Roy, S.; Quintana, A. M.

10.1101/2023.01.27.525860 — developmental biology — Posted on 2023-01-27

461 A billion years arms-race between viruses, virophages and eukaryotes

Nino Barreat, J. G.; Katzourakis, A.

10.1101/2021.04.20.440574 — microbiology — Posted on 2023-01-27

462 Poorer Sleep Health is Associated with Altered Brain Activation During Cognitive Control Processing in Healthy Adults

Smevik, H.; Habli, S.; Saksvik, S. B.; Kliem, E.; Evensmoen, H. R.; Conde, V.; Petroni, A.; Asarnow, R. F.; Dennis, E. L.; Eikenes, L.; Kallestad, H.; Sand, T.; Thompson, P. M.; Saksvik-Lehouillier, I.; Haberg, A. K.; Olsen, A.

10.1101/2022.10.28.512671 — neuroscience — Posted on 2023-01-27

463 Resource allocation to cell envelopes and the scaling of bacterial growth rate

Trickovic, B.; Lynch, M.

10.1101/2022.01.07.475415 — systems biology — Posted on 2023-01-27

464 Terrestrial endotherms trade body temperature regulation for the stress response

Tabh, J. K. R.; Hartjes, M.; Burness, G.

10.1101/2023.01.09.523310 — physiology — Posted on 2023-01-27

465 Molten globule driven and self-downmodulated phase separation of a viral factory scaffold

de Prat Gay, G.; Salgueiro, M.; Camporeale, G.; Visentin, A.; Aran, M.; Pellizza, L.; Esperante, S. A.; Corbat, A.; Grecco, H.; Sousa, B.; Esperon, R.; Borkosky, S.

10.1101/2023.01.27.525862 — biophysics — Posted on 2023-01-27

466 Protein network analysis links the NSL complex to Parkinson's disease and mitochondrial biology

Kelly, K.; Lewis, P.; Plun-Favreau, H.; Manzoni, C.

10.1101/2023.01.27.524249 — neuroscience — Posted on 2023-01-27

467 Peripheral macrophages causally contribute to disease onset and progression in the Ndufs4(KO) model of Leigh syndrome

Hanaford, A.; Khanna, A.; James, K.; Chen, Y.; Mulholland, M.; Kayser, B.; Truong, V.; Sedensky, M. M.; Morgan, P. G.; Kalia, V.; Sarkar, S.; Johnson, S. C.

10.1101/2023.01.27.525842 — pathology — Posted on 2023-01-27

468 Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells

Ippolito, M. R.; Zerbib, J.; Eliezer, Y.; Reuveni, E.; Vigano', S.; De Feudis, G.; Kadmon, A. S.; Vigorito, I.; Martin, S.; Laue, K.; Cohen-Sharir, Y.; Scorzoni, S.; Vazquez, F.; Santaguida, S.; Ben-David, U.

10.1101/2023.01.27.525826 — cancer biology — Posted on 2023-01-27

469 Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Zerbib, J.; Ippolito, M. R.; Eliezer, Y.; De Feudis, G.; Reuveni, E.; Kadmon, A. S.; Martin, S.; Vigano', S.; Leor, G.; Berstler, J.; Laue, K.; Cohen-Sharir, Y.; Scorzoni, S.; Vazquez, F.; Ben-David, U.; Santaguida, S.

10.1101/2023.01.27.525822 — cancer biology — Posted on 2023-01-27

470 Cannabidiol sensitizes TRPV2 channels to activation by 2-APB

Gochman, A.; Tan, X.; Bae, C.; Chen, H.; Swartz, K. J.; Jara-Oseguera, A.

10.1101/2023.01.27.525817 — biophysics — Posted on 2023-01-27

471 Efficiently Quantifying DNA Methylation for Bulk- and Single-cell Bisulfite Data

Fischer, J.; Schulz, M. H.

10.1101/2023.01.27.525734 — bioinformatics — Posted on 2023-01-27

472 Engineered Antiviral Sensor Targets Infected Mosquitoes

Dalla Benetta, E.; Lopez-Denman, A. J.; Li, H.-H.; Masri, R. A.; Brogan, D. J.; Bui, M.; Yang, T.; Li, M.; Dunn, M.; Klein, M. J.; Jackson, S.; Catalan, K.; Blasdell, K. R.; Tng, P.; Antoshechkin, I.; Alphey, L. S.; Paradkar, P. N.; Akbari, O.

10.1101/2023.01.27.525922 — bioengineering — Posted on 2023-01-27

473 A Fully Defined Synthetic Medium Mimicking Sugar Cane Molasses

Eliodorio, K. P.; Cunha, G. C. d. G. e.; Lino, F. S. d. O.; Sommer, M. O. A.; Gombert, A. K.; Giudici, R.; Basso, T. O.

10.1101/2023.01.27.525923 — bioengineering — Posted on 2023-01-27

474 Downfield Proton MRSI with whole-brain coverage at 3T

Ozdemir, I.; Ganji, S.; Gillen, J.; Etyemez, S.; Povazan, M.; Barker, P. B.

10.1101/2023.01.27.525726 — bioengineering — Posted on 2023-01-27

475 Environmental and molecular regulation of asexual reproduction in the sea anemone Nematostella vectensis

Al-Shaer, L.; Leach, W.; Baban, N.; Yagodich, M.; Gibson, M. C.; Layden, M. J.

10.1101/2023.01.27.525773 — animal behavior and cognition — Posted on 2023-01-27

476 Multi-omics analysis identifies LBX1 and NHLH1 as central regulators of human midbrain dopaminergic neuron differentiation

Gomez Ramos, B.; Ohnmacht, J.; de Lange, N.; Ginolhac, A.; Valceschini, E.; Rakovic, A.; Halder, R.; Massart, F.; Klein, C.; Krause, R.; Schulz, M.; Sauter, T.; Krueger, R.; Sinkkonen, L.

10.1101/2023.01.27.525898 — genomics — Posted on 2023-01-27

477 Mitotic heritability of DNA methylation at intermediately methylated sites is imprecise

Hay, A. D.; Kessler, N. J.; Gebert, D.; Takahashi, N.; Tavares, H.; Karam Teixeira, F.; Ferguson-Smith, A. C.

10.1101/2023.01.27.525699 — genetics — Posted on 2023-01-27

478 Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways

Underhill, E. J.; Toettcher, J. E.

10.1101/2023.01.27.525895 — developmental biology — Posted on 2023-01-27

479 Dynamic fate map of hindbrain rhombomeres in zebrafish

Kamaraj, M.; Savy, T.; Desnoulez, S. S.; Peyrieras, N.; Frain, M.

10.1101/2023.01.27.523420 — developmental biology — Posted on 2023-01-27

480 A better brain? Alternative spliced STIM2 in hominoids arises with synapse formation and creates a gain-of-function variant

Poth, V.; Do, H. T. T.; Foerderer, K.; Tschernig, T.; Alansary, D.; Helms, V.; Niemeyer, B. A.

10.1101/2023.01.27.525873 — cell biology — Posted on 2023-01-27

481 Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.

Park, S.-H.; Helsley, R. N.; Fadhul, T.; Willoughby, J. L. S.; Noetzli, L.; Tu, H.-C.; Solheim, M. H.; Fujisaka, S.; Pan, H.; Dreyfuss, J. M.; Bons, J.; Rose, J.; King, C. D.; Schilling, B.; Lusis, A. J.; Pan, C.; Gupta, M.; Kulkarni, R. N.; Fitzgerald, K.; Kern, P. A.; Divanovic, S.; Kahn, R.; Softic, S.

10.1101/2023.01.27.525605 — molecular biology — Posted on 2023-01-27

482 Nanopore-based direct RNA sequencing of the Trypanosoma brucei transcriptome identifies novel lncRNAs

Kruse, E.; Goringer, H. U.

10.1101/2023.01.27.525864 — molecular biology — Posted on 2023-01-27

483 Backup transcription factor binding sites protect human genes from mutations in the promoter

Brown, J. C.

10.1101/2023.01.27.525856 — molecular biology — Posted on 2023-01-27

484 Mycobacterium tuberculosis SecA2-dependent activation of host Rig-I/MAVs signaling is not conserved in Mycobacterium marinum

Serene, L. G.; Champion, P. A.; Schorey, J. S.

10.1101/2023.01.27.525853 — microbiology — Posted on 2023-01-27

485 Steamed broccoli sprouts alleviate gut inflammation and retain gut microbiota against DSS-induced symptoms.

Holman, J. M.; Colucci, L.; Baudewyns, D.; Balkan, J.; Hunt, T.; Hunt, B.; Holcomb, L.; Chen, G.; Moses, P. L.; Mawe, G. M.; Zhang, T.; Li, Y.; Ishaq, S. L.

10.1101/2023.01.27.522641 — microbiology — Posted on 2023-01-27

486 Expanding the repertoire of the plant infecting ophioviruses

Debat, H. J.; Garcia, M. L.; Bejerman, N.

10.1101/2023.01.27.525910 — microbiology — Posted on 2023-01-27

487 The MIR-NAT MAPT-AS1 does not regulate Tau expression in human neurons

Policarpo, R.; Wolfs, L.; Martinez-Montero, S.; Vandermeulen, L.; Royaux, I.; Van Peer, G.; Mestdagh, P.; Sierksma, A.; De Strooper, B.; d'Ydewalle, C.

10.1101/2023.01.27.525631 — neuroscience — Posted on 2023-01-27

Hall, A. R.; Choi, Y. K.; Im, W.; Vavylonis, D.

10.1101/2023.01.27.525865 — biophysics — Posted on 2023-01-27

489 Biventricular interaction during acute left ventricular ischemia in mice: a combined in-vivo and in-silico approach

Colebank, M.; Taylor, R.; Hacker, T.; Chelser, N.

10.1101/2023.01.26.525736 — bioengineering — Posted on 2023-01-27

490 The Australasian dingo archetype: De novo chromosome-length genome assembly, DNA methylome, and cranial morphology

Ballard, J. W. O.; Field, M. A.; Edwards, R. J.; Wilson, L. A. B.; Koungoulos, L. G.; Rosen, B. R.; Chernoff, B.; Dudchenko, O.; Omer, A.; Keilwagen, J.; Skvortsova, K.; Bogdanovic, O.; Chan, E.; Zammit, R.; Hayes, V.; Aiden, E. L.

10.1101/2023.01.26.525801 — genomics — Posted on 2023-01-27

491 Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites and pathways that regulate lifespan

Phua, C. Z. J.; Zhao, X.; Turcios-Hernandez, L.; McKernan, M.; Abyadeh, M.; Ma, S.; Promislow, D. E.; Kaeberlein, M.; Kaya, A.

10.1101/2023.01.26.525799 — genetics — Posted on 2023-01-27

492 Acinar-ductal cell rearrangement drives pancreas branching morphogenesis in an IGF/PI3K-dependent manner

Darrigrand, J.-F.; Salowka, A.; Spagnoli, F. M.

10.1101/2023.01.26.525717 — developmental biology — Posted on 2023-01-27

493 Pooled CRISPR screening of high-content cellular phenotypes by ghost cytometry

Tsubouchi, A.; An, Y.; Kawamura, Y.; Yanagihashi, Y.; Murata, Y.; Teranishi, K.; Ishiguro, S.; Aburatani, H.; Yachie, N.; Ota, S.

10.1101/2023.01.26.525784 — cell biology — Posted on 2023-01-27

494 IL-13 promotes sensory-sympathetic neurons crosstalk in asthma

Crosson, T.; Bhat, S.; Wang, J.-C.; Salaün, C.; Roversi, K.; Herzog, H.; Rafei, M.; Blunck, R.; Talbot, S.

10.1101/2023.01.26.525731 — neuroscience — Posted on 2023-01-27

495 scMINER: a mutual information-based framework for identifying hidden drivers from single-cell omics data

Ding, L.; Shi, H.; Qian, C.; Burdyshaw, C.; Veloso, J. P.; Khatamian, A.; Pan, Q.; Dhungana, Y.; Xie, Z.; Risch, I.; Yang, X.; Huang, X.; Yan, L.; Rusch, M.; Brewer, M.; Yan, K.-K.; Chi, H.; Yu, J.

10.1101/2023.01.26.523391 — systems biology — Posted on 2023-01-27

496 N-arylpyrazole NOD2 agonists promote immune checkpoint inhibitor therapy

Griffin, M. E.; Tsukidate, T.; Hang, H. C.

10.1101/2023.01.26.525573 — cancer biology — Posted on 2023-01-27

497 Hyperextended telomeres promote C-circle formation in telomerase positive human cells

Jones, C. Y.; Williams, C. L.; Moreno, S. P.; Morris, D. K.; Mondello, C.; Karlseder, J.; Bertuch, A. A.

10.1101/2023.01.26.525615 — cancer biology — Posted on 2023-01-27

498 Autoinhibited kinesin-1 adopts a hierarchical folding pattern

Tan, Z.; Yue, Y.; da Veiga Leprevost, F.; Haynes, S. E.; Basrur, V.; Nesvizhskii, A. I.; Verhey, K. J.; Cianfrocco, M. A.

10.1101/2023.01.26.525761 — biophysics — Posted on 2023-01-27

499 Protein Representation Learning via Knowledge Enhanced Primary Structure Modeling

Zhou, H.-Y.; Fu, Y.; Zhang, Z.; Bian, C.; Yu, Y.

10.1101/2023.01.26.525795 — bioinformatics — Posted on 2023-01-27

500 Multi-omics data integration approach identifies potential biomarkers for Prostate cancer

Chikwambi, Z.; Hidjo, M.; Chikondowa, P.; Afolabi, L.; Aketch, V.; Jayeoba, G.; Awe, O. I.; Enoma, D. O.

10.1101/2023.01.26.522643 — bioinformatics — Posted on 2023-01-27

501 Phenotypically Complex Living Materials Containing Engineered Cyanobacteria

Datta, D.; Weiss, E. L.; Wangpraseurt, D.; Hild, E.; Chen, S.; Golden, J. W.; Golden, S. S.; Pokorski, J. K.

10.1101/2023.01.26.525792 — bioengineering — Posted on 2023-01-27

502 Ultra-Fast Bioorthogonal Spin-Labeling and Distance Measurements in Mammalian Cells Using Small, Genetically Encoded Tetrazine Amino Acids

Mehl, R.; Jana, S.; Evans, E. G. B.; Jang, H. S.; Zhang, S.; Zhang, H.; Rajca, A.; Gordon, S. E.; Zagotta, W. N.; Stoll, S.

10.1101/2023.01.26.525763 — biochemistry — Posted on 2023-01-27

503 Understanding Painful versus Non-Painful Dental Pain in Male and Female Patients: A Transcriptomic Analysis of Human Biopsies

Patel, B. R.; Eskander, M.; Chang, F.-M.; Chapa, B.; Ruparel, S.; Lai, Z.; Chen, Y.; Akopian, A.; Ruparel, N. B.

10.1101/2023.01.26.525783 — genomics — Posted on 2023-01-27

504 Molecular mechanisms of coronary artery disease risk at the PDGFD locus

Kim, H.-J.; Cheng, P.; Travisano, S.; Weldy, C. S.; Monteiro, J.; Kundu, R.; Nguyen, T.; Sharma, D.; Shi, H.; Liu, B.; Lin, Y.; Haldar, S.; Jackson, S.; Quertermous, T.

10.1101/2023.01.26.525789 — genetics — Posted on 2023-01-27

505 The LCLAT1/LYCAT acyltransferase supports EGF-mediated phosphatidylinositol-3,4,5-trisphosphate and Akt signalling

Chan, V.; Bone, L.; Anderson, K. E.; Zhang, K.; Orofiamma, L.; Awadeh, Y.; Lee, D. K. C.; Fu, N. J.; Chow, J. T. S.; Salmena, L.; Stephens, L. R.; Hawkins, P. T.; Antonescu, C. N.; Botelho, R. J.

10.1101/2023.01.26.524308 — cell biology — Posted on 2023-01-27

506 Integrated post-genomic cell wall analysis reveals floating biofilm formation associated with high expression of flocculins in the pathogen Candida krusei.

Alvarado, M.; Gomez-Navajas, J. A.; Blazquez-Munoz, M. T.; Gomez-Molero, E.; Berbegal, C.; Eraso, E.; Kramer, G.; De Groot, P.

10.1101/2023.01.26.525814 — cell biology — Posted on 2023-01-27

507 Pseudomonas aeruginosa Siderophores Damage Lung Epithelial Cells and Promote Inflammation

Kang, D.; Kirienko, N.

10.1101/2023.01.26.525796 — cell biology — Posted on 2023-01-27

508 EVIDENCE FOR ANGIOTENSIN II AS A NATURALLY EXISTING SUPPRESSOR FOR THE NATRIURETIC PEPTIDE SYSTEM

Ma, X.; Iyer, S. R.; Ma, X.; Reginauld, S. H.; Chen, Y.; Pan, S.; Zheng, Y.; Moroni, D.; Yu, Y.; Zhang, L.; Cannone, V.; Chen, H. H.; Ferrario, C. M.; Sangaralingham, J.; Burnett, J. C.

10.1101/2023.01.26.525806 — molecular biology — Posted on 2023-01-27

509 Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10-/- mouse model of inflammatory bowel disease

Armstrong, H.; Rahbari, M.; Park, H.; Sharon, D.; Thiesen, A.; Hotte, N.; Sun, N.; Syed, H.; Abofayed, H.; Wang, W.; Madsen, K.; Wine, E.; Mason, A.

10.1101/2023.01.26.525771 — microbiology — Posted on 2023-01-27

510 Bacterial mechanosensing of surface stiffness promotes signaling and growth leading to biofilm formation by Pseudomonas aeruginosa

Wang, L.; Wong, Y.-C.; Correira, J.; Wancura, M.; Geiger, C.; Webster, S. S.; Butler, B.; O'Toole, G. A.; Langford, R.; Brown, K.; Dortdivanlioglu, B.; Webb, L.; Cosgriff-Hernandez, E.; Gordon, V.

10.1101/2023.01.26.525810 — microbiology — Posted on 2023-01-27

511 Streptococcus pneumoniae drives specific and lasting Natural Killer cell memory

Camarasa, T. M. N.; Torne, J.; Chevalier, C.; Rasid, O.; Hamon, M. A.

10.1101/2023.01.26.525815 — microbiology — Posted on 2023-01-27

512 Glutathionylation of Pyruvate Dehydrogenase Complex E2 Protein During Acute Inflammation Is Magnified By Mitochondrial Oxidative Stress, Enhancing Cell Death

Long, D. L.; Poole, L. B.; McCall, C. E.

10.1101/2023.01.26.525791 — immunology — Posted on 2023-01-27

513 PP1β opposes classic PP1 function, inhibiting spine maturation and promoting LTP

Foley, K.; McKee, C.; Ganguly, A.; Barnett, D.; Ward, N.; Mayer, A.; Zhang, Y.; Nairn, A.; Xia, H.

10.1101/2023.01.26.525737 — neuroscience — Posted on 2023-01-27

514 Emergence of distributed working memory in a human brain network model

Feng, M.; Bandyopadhyay, A.; Mejias, J. F.

10.1101/2023.01.26.525779 — neuroscience — Posted on 2023-01-27

515 Senescence of cortical neurons following persistent DNA double-strand breaks induces cerebrovascular lesions

Feng, Y.; Kopsidas, C. A.; Lowe, C. C.; Zhang, J.; Zhou, X.; Kang, W.

10.1101/2023.01.26.525738 — neuroscience — Posted on 2023-01-27

516 Neural tuning instantiates prior expectations in the human visual system

Harrison, W.; Bays, P.; Rideaux, R.

10.1101/2023.01.26.525790 — neuroscience — Posted on 2023-01-27

517 The Effect of Electrical Resonance in Neurons upon the Instability of Electrical Nerve Stimulations

Yu, S.; Yue, W.; Guo, T.; Liu, Y.; Zhang, Y.; Khademi, S.; Zhou, T.; Xu, Z.; Song, B.; Wu, T.; Liu, F.; Tai, Y.; Yu, X.; Wang, M.

10.1101/2023.01.26.525813 — neuroscience — Posted on 2023-01-27

518 Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism.

Stark, R.; Dempsey, H.; Sassi, M.; Kleeman, E.; Davies, J. S.; Zigman, J.; Andrews, Z. B.

10.1101/2023.01.26.525804 — neuroscience — Posted on 2023-01-27

519 Multimodal models of animal sex: breaking binaries leads to a better understanding of ecology and evolution

McLaughlin, J. F.; Brock, K. M.; Gates, I.; Pethkar, A.; Piattoni, M.; Rossi, A.; Lipshutz, S.

10.1101/2023.01.26.525769 — zoology — Posted on 2023-01-27

520 The Spread of Interferon-γ in Melanomas is Highly Spatially Confined, Driving Non-Genetic Variability in Tumor Cells

Centofanti, E.; Wang, C.; Iyer, S.; Krichevsky, O.; Oyler-Yaniv, A.; Oyler-Yaniv, J.

10.1101/2023.01.26.525713 — systems biology — Posted on 2023-01-27

521 Cell cycle oscillations driven by two interlinked bistable switches

Parra-Rivas, P.; Ruiz-Reynes, D.; Gelens, L.

10.1101/2023.01.26.525632 — systems biology — Posted on 2023-01-27

522 Top-down Proteomics of Myosin Light Chain Isoforms Define Chamber-Specific Expression in the Human Heart

Bayne, E. F.; Rossler, K. J.; Gregorich, Z. R.; Aballo, T. J.; Roberts, D. S.; Chapman, E. A.; Guo, W.; Ralphe, J. C.; Kamp, T. J.; Ge, Y.

10.1101/2023.01.26.525767 — systems biology — Posted on 2023-01-27

523 Winning a competitive research award decreases time to degree in bioscience PhD programs, but not for everyone

Alvero, A.; Pena, C.; Moore, A. R.; Barron, C. B.; Steele, L.; Eberle, S.; Botham, C. M.

10.1101/2023.01.26.525758 — scientific communication and education — Posted on 2023-01-27

524 Scientific civility and academic performance

Camacho, E.; Dragotakes, Q.; Hartshorn, I.; Casadevall, A.; Buccino, D. L.

10.1101/2023.01.26.525747 — scientific communication and education — Posted on 2023-01-27

525 Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

Chen, J.; Amoozgar, Z.; LIU, X.; Aoki, S.; Liu, Z.; Shin, S.; Matsui, A.; Pu, Z.; Lei, P.-J.; Datta, M.; Zhu, L.; Ruan, Z.; Shi, L.; Staiculescu, D.; Inoue, K.; Munn, L. L.; Fukumura, D.; Huang, P.; Bardeesy, N.; Ho, W. J.; Jain, R.; Duda, D. G.

10.1101/2023.01.26.525680 — cancer biology — Posted on 2023-01-27

526 Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.

Seong, C.-S.; Huang, C.; Boese, A. C.; Hou, Y.; Koo, J.; Mouw, J. K.; Rupji, M.; Joseph, G.; Johnston, H. R.; Claussen, H.; Switchenko, J. M.; Behera, M.; Churchman, M.; Kolesar, J. M.; Arnold, S. M.; Kerrigan, K.; Akerley, W.; Colman, H.; Johns, M. A.; Arciero, C.; Zhou, W.; Marcus, A. I.; Ramalingam, S. S.; Fu, H.; Gilbert-Ross, M.

10.1101/2023.01.26.525772 — cancer biology — Posted on 2023-01-27

527 The impact of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids

Lumibao, J. C.; Okhovat, S. R.; Peck, K.; Lande, K.; Zou, J.; Engle, D. D.

10.1101/2023.01.26.525757 — cancer biology — Posted on 2023-01-27

528 Single fluorogen imaging reveals spatial inhomogeneities within biomolecular condensates

Wu, T.; King, M. R.; Farag, M.; Pappu, R. V.; Lew, M. D.

10.1101/2023.01.26.525727 — biophysics — Posted on 2023-01-27

529 The mineralocorticoid receptor forms higher order oligomers upon DNA binding

Fettweis, G.; Johnson, T. A.; Almeida-Prieto, B.; Presman, D. M.; Hager, G. L.; Alvarez de la Rosa, D.

10.1101/2023.01.26.525752 — biophysics — Posted on 2023-01-27

530 How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain

JANG, H.; Chen, J.; Iakoucheva, L. M.; Nussinov, R.

10.1101/2023.01.26.525746 — biophysics — Posted on 2023-01-27

531 Extracting nanoscale morphology from localizations

Marin, Z.; Fuentes, L. A.; Bewersdorf, J.; Baddeley, D.

10.1101/2023.01.26.525798 — biophysics — Posted on 2023-01-27

532 TRPV1 Opening is Stabilized Equally by Its Four Subunits

Li, S.; Nguyen, P. T.; Vu, S.; Yarov-Yarovoy, V.; Zheng, J.

10.1101/2023.01.26.525787 — biophysics — Posted on 2023-01-27

533 Structure of human NaV1.6 channel reveals Na+ selectivity and pore blockade by 4,9-anhydro-tetrodotoxin

Li, Y.; Yuan, T.; Huang, B.; Zhou, F.; Peng, C.; Li, X.; Qiu, Y.; Yang, B.; Zhao, Y.; Huang, Z.; Jiang, D.

10.1101/2023.01.26.525614 — biophysics — Posted on 2023-01-27

534 Building a Pangenome Alignment Index via Recursive Prefix-Free Parsing

Oliva, M.; Gagie, T.; Boucher, C.

10.1101/2023.01.26.525723 — bioinformatics — Posted on 2023-01-27

535 The Ontology of Biological Attributes (OBA) - Computational Traits for the Life Sciences

Stefancsik, R.; Balhoff, J. P.; Balk, M. A.; Ball, R. L.; Bello, S. M.; Caron, A. R.; Chesler, E. J.; de Souza, V.; Gehrke, S.; Haendel, M.; Harris, L. W.; Harris, N. L.; Ibrahim, A.; Koehler, S.; Matentzoglu, N.; McMurry, J. A.; Mungall, C. J.; Munoz-Torres, M. C.; Putman, T. E.; Robinson, P. N.; Smedley, D.; Sollis, E.; Thessen, A. E.; Vasilevsky, N.; Walton, D. O.; Osumi-Sutherland, D.

10.1101/2023.01.26.525742 — bioinformatics — Posted on 2023-01-27

536 GRN-VAE: A Simplified and Stabilized SEM Model for Gene Regulatory Network Inference

Zhu, H.; Slonim, D.

10.1101/2023.01.26.525733 — bioinformatics — Posted on 2023-01-27

537 Evaluating Retention Index Score Assumptions to Refine GC-MS Metabolite Identification

Degnan, D. J.; Bramer, L. M.; Flores, J. E.; Paurus, V. L.; Corilo, Y. E.; Clendinen, C. S.

10.1101/2023.01.26.525730 — bioinformatics — Posted on 2023-01-27

538 Assessing the functional impact of protein binding site definition

Nandigrami, P.; Fiser, A.

10.1101/2023.01.26.525812 — bioinformatics — Posted on 2023-01-27

539 L0 segmentation enables data-driven concise representations of diverse epigenomic data

Balci, A. T.; Chikina, M.

10.1101/2023.01.26.525794 — bioinformatics — Posted on 2023-01-27

540 A computational model of chemically and mechanically induced platelet plug formation

Cardillo, G.; Barakat, A. I.

10.1101/2023.01.26.525741 — bioengineering — Posted on 2023-01-27

541 Behavioural individuality determines infection risk in clonal ant colonies

Li, Z.; Frank, E. T.; Oliveira-Honorato, T.; Azuma, F.; Bachmann, V.; Parker, D. J.; Schmitt, T.; Economo, E. P.; Ulrich, Y.

10.1101/2023.01.26.525341 — animal behavior and cognition — Posted on 2023-01-27

542 Multi-Omic Signatures of Sarcoidosis and Progression in Bronchoalveolar Lavage Cells

Konigsberg, I. R.; Lin, N. W.; Liao, S.-Y.; Liu, C.; MacPhail, K.; Mroz, M. M.; Davidson, E.; Restrepo, C. I.; Sharma, S.; Li, L.; Maier, L. A.; Yang, I. V.

10.1101/2023.01.26.525601 — genomics — Posted on 2023-01-27

543 Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues

Vicari, M.; Mirzazadeh, R.; Nilsson, A.; Shariatgorji, R.; Bjarterot, P.; Larsson, L.; Lee, H.; Nilsson, M.; Foyer, J.; Ekvall, M.; Czarnewski, P.; Zhang, X.; Svenningsson, P.; Andren, P.; Lundeberg, J.

10.1101/2023.01.26.525195 — genomics — Posted on 2023-01-27

544 Sex-differences in the genetic architecture of individual recombination rates in wild house sparrows (Passer domesticus).

McAuley, J. B.; Servin, B.; Peters, L.; Hagen, I. J.; Niskanen, A. K.; Ringsby, T. H.; Husby, A.; Jensen, H.; Johnston, S. E.

10.1101/2023.01.26.525019 — genetics — Posted on 2023-01-27

545 Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension

Munroe, P. B.; van Duijvenboden, S.; Ramirez, J.; Young, W. J.; Olczak, K. J.; Ahmed, F.; Alhammadi, M. J. A. Y.; Bell, C. G.; Morris, A.

10.1101/2023.01.26.525702 — genetics — Posted on 2023-01-27

546 The molecular clock in long-lived tropical trees is independent of growth rate

Imai, R.; Fujino, T.; Tomimoto, S.; Ohta, K.; Na'iem, M.; Indrioko, S.; Widiyatno, ; Purnomo, S.; Morales, A. M.; Nizhynska, V.; Tani, N.; Suyama, Y.; Sasaki, E.; Kasahara, M.; Satake, A.

10.1101/2023.01.26.525665 — evolutionary biology — Posted on 2023-01-27

547 Population genomics of the mostly thelytokous Diplolepis rosae (Linnaeus, 1758) (Hymenoptera: Cynipidae) reveals population-specific selection for sex

Mozhaitseva, K.; Tourrain, Z.; Branca, A.

10.1101/2023.01.26.525659 — evolutionary biology — Posted on 2023-01-27

548 Genetic diversity of the eastern black rhinoceros (Diceros bicornis michaeli) in Tanzania; implications for future conservation

Hopcraft, G.; Eblate, E. M.; Chuma, I. S.; Otiende, M. Y.; Macha, E. S.; Wambura, D.; Kilbride, E.; Mable, B. K.; Mellya, R. V.

10.1101/2023.01.26.525648 — evolutionary biology — Posted on 2023-01-27

549 Age specific impacts of vegetation functional traits on gastro-intestinal nematode parasite burdens in a large herbivore

Wiersma, E.; Pakeman, R. J.; Bal, X.; Pilkington, J. G.; Pemberton, J. M.; Nussey, D. H.; Sweeny, A. R.

10.1101/2023.01.26.525546 — ecology — Posted on 2023-01-27

550 Niche conservatism in a generalist felid: low differentiation of the climatic niche among subspecies of the leopard (Panthera pardus)

Leedham, S.; Paijmans, J. L. A.; Manica, A.; Leonardi, M.

10.1101/2023.01.26.525491 — ecology — Posted on 2023-01-27

551 Environmental DNA reveals patterns of biological invasion in an inland sea

Duprey, J.; Gallego, R.; Klinger, T.; Kelly, R. P.

10.1101/2023.01.26.525668 — ecology — Posted on 2023-01-27

552 Can snare removal safeguard protected areas caught in the Southeast Asian snaring crisis? Promises and perspectives

Tilker, A.; Niedballa, J.; Viet, H. L.; Abrams, J. F.; Marescot, L.; Wilkinson, N.; Rawson, B. R.; Sollmann, R.; Wilting, A.

10.1101/2023.01.26.525728 — ecology — Posted on 2023-01-27

553 Decoupling of transcript and protein concentrations ensures budding yeast histone homeostasis in different nutrient conditions

Chatzitheodoridou, D.; Bureik, D.; Padovani, F.; Nadimpalli, K. V.; Schmoller, K. M.

10.1101/2023.01.26.525696 — cell biology — Posted on 2023-01-27

554 The nanoscale organization of reticulon 4 shapes local endoplasmic reticulum structure in situ

Fuentes, L. A.; Marin, Z.; Tyson, J.; Baddeley, D.; Bewersdorf, J.

10.1101/2023.01.26.525608 — cell biology — Posted on 2023-01-27

555 A flexible loop in the paxillin LIM3 domain mediates direct binding to integrin β3

Baade, T.; Michaelis, M.; Prestel, A.; Paone, C.; Klishin, N.; Scheinost, L.; Nedielkov, R.; Hauck, C. R.; Moller, H. M.

10.1101/2023.01.26.525744 — cell biology — Posted on 2023-01-27

556 Mechanistic basis of staphylococcal interspecies competition for skin colonization

Maciag, J. J.; Chantraine, C.; Mills, K. B.; Yadav, R.; Yarawsky, A. E.; Chaton, C. T.; Vinod, D.; Fitzkee, N. C.; Mathelie-Guinlet, M.; Dufrene, Y. F.; Fey, P. D.; Horswill, A. R.; Herr, A. B.

10.1101/2023.01.26.525635 — microbiology — Posted on 2023-01-27

557 The role of B cells in immune cell activation in polycystic ovary syndrome

Ascani, A.; Torstensson, S.; Risal, S.; Lu, H.; Eriksson, G.; Li, C.; Teshl, S.; Menezes, J.; Sandor, K.; Ohlsson, C.; Svensson, C.; Karlsson, M.; Stradner, M. H.; Obermayer-Pietsch, B.; Stener-Victorin, E.

10.1101/2023.01.26.525671 — immunology — Posted on 2023-01-27

558 Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction

Selli, M. E.; Landmann, J. H.; Terekhova, M.; Lattin, J.; Heard, A.; Hsu, Y.-S.; Chang, T.-C.; Warrington, J. M.; Ha, H.; Kingston, N.; Hogg, G.; Slade, M.; Berrien-Elliot, M. M.; Foster, M.; Kersting-Schadek, S.; Gruszczynska, A.; DeNardo, D.; Fehniger, T. A.; Artyomov, M.; Singh, N.

10.1101/2023.01.26.525725 — immunology — Posted on 2023-01-27

559 Neural substrates of parallel devaluation-sensitive and devaluation-insensitive Pavlovian learning in humans

Pool, E. R.; Pauli, W. M.; Cross, L.; O'Doherty, J. P.

10.1101/2023.01.26.525637 — neuroscience — Posted on 2023-01-27

560 Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution

Bartos, L. M.; Kirchleitner, S. V.; Kolabas, Z. I.; Quach, S.; Blobner, J.; Mueller, S. A.; Ulukaya, S.; Hoeher, L.; Horvath, I.; Wind-Mark, K.; Holzgreve, A.; Ruf, V. C.; Gold, L.; Kunze, L. H.; Kunte, S. T.; Beumers, P.; Antons, M.; Zatcepin, A.; Briel, N.; Hoermann, L.; Messerer, D.; Bartenstein, P.; Riemenschneider, M. J.; Lindner, S.; Ziegler, S.; Herms, J.; Lichtenthaler, S. F.; Ertuerk, A.; Tonn, J. C.; von Baumgarten, L.; Albert, N. L.; Brendel, M.

10.1101/2023.01.26.522174 — neuroscience — Posted on 2023-01-27

561 Biohybrid restoration of the hippocampal loop re-establishes the non-seizing state in an in vitro model of limbic seizures

Caron, D.; Buccelli, S.; Canal-Alonso, A.; Puthanmadam Subramaniyam, N.; Farsani, J.; Pruzzo, G.; Linares Barranco, B.; Hyttinen, J.; Corchado, J. M.; Chiappalone, M.; Panuccio, G.

10.1101/2023.01.26.525627 — neuroscience — Posted on 2023-01-27

562 The intrinsic clock of the hippocampal subfield CA3 rescues limbic seizures in a biohybrid graft-host interaction in vitro

Caron, D.; Buccelli, S.; Canal-Alonso, A.; Hernandez, M.; Pruzzo, G.; Corchado, J. M.; Chiappalone, M.; Panuccio, G.

10.1101/2023.01.26.525630 — neuroscience — Posted on 2023-01-27

563 Heparan sulfates regulate axonal excitability and context generalization through Ca2+/calmodulin-dependent protein kinase II

Song, I.; Kuznetsova, T.; Baidoe-Ansah, D.; Mirzapourdelavar, H.; Senkov, O.; Hayani, H.; Mironov, A.; Kaushik, R.; Druzin, M.; Johansson, S.; Dityatev, A.

10.1101/2023.01.26.524131 — neuroscience — Posted on 2023-01-27

564 The sequence of regional structural disconnectivity due to multiple sclerosis lesions

Tozlu, C.; Olafson, E.; Jamison, K.; Demmon, E.; Kaunzner, U.; Marcille, M.; Zinger, N.; Michaelson, N.; Safi, N.; Nguyen, T.; Gauthier, S.; Kuceyeski, A.

10.1101/2023.01.26.525537 — neuroscience — Posted on 2023-01-27

565 Electrophysiological signatures of veridical head direction in humans

Griffiths, B. J.; Schreiner, T.; Schaefer, J.; Vollmar, C.; Kaufmann, E.; Quach, S.; Remi, J.; Noachtar, S.; Staudigl, T.

10.1101/2023.01.26.525724 — neuroscience — Posted on 2023-01-27

566 Early whole-body mutant huntingtin lowering preserves proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model

Sapp, E.; Shing, K.; Boudi, A.; Liu, S.; Seeley, C.; Marchionini, D.; DiFiglia, M.; Kegel-Gleason, K. B.

10.1101/2023.01.26.525697 — neuroscience — Posted on 2023-01-27

567 Considering dynamic nature of the brain: the clinical importance of connectivity variability in machine learning classification and prediction

Song, I.; Lee, T.-H.

10.1101/2023.01.26.525765 — neuroscience — Posted on 2023-01-27

568 Analysis of National Institutes of Health Grant K99 to R00 Transitions from 2007 to 2022

Tyrrell, D. J.

10.1101/2023.01.26.525751 — scientific communication and education — Posted on 2023-01-27

569 Drosophila activins adapt gut size to food intake and promote regenerative growth

Christensen, C. F.; Laurichesse, Q.; Loudhaief, R.; Colombani, J.; Andersen, D. S.

10.1101/2023.01.26.525639 — physiology — Posted on 2023-01-27

570 Activated Oncostatin M signaling drives cancer-associated skeletal muscle wasting

Domaniku, A.; Agca, S.; Toledo, B.; Bilgic, S. N.; Kashgari, A. E.; Kir, S.

10.1101/2023.01.26.525658 — cancer biology — Posted on 2023-01-27

571 Excitation energy transfer between higher excited states of photosynthetic pigments: 2. Chlorophyll b is a B band energy trap

Gotze, J. P.; Lokstein, H.

10.1101/2023.01.26.525641 — biophysics — Posted on 2023-01-27

Duitama Gonzalez, C.; Vicedomini, R.; Lemane, T.; Rascovan, N.; Richard, H.; Chikhi, R.

10.1101/2023.01.26.525439 — bioinformatics — Posted on 2023-01-27

573 Species-aware DNA language modeling

Gankin, D.; Karollus, A.; Grosshauser, M.; Klemon, K.; Hingerl, J.; Gagneur, J.

10.1101/2023.01.26.525670 — bioinformatics — Posted on 2023-01-27

574 SeqPanther: Sequence manipulation and mutation statistics toolset

San, J. E.; Wyke, S. V.; Tegally, H.; Wilkinson, E.; Eche, S.; Kanzi, A.; Oliveira, T. d.; Kiran, A. E.

10.1101/2023.01.26.525629 — bioinformatics — Posted on 2023-01-27

575 PortPred: exploiting deep learning embeddings of amino acid sequences for the identification of transporter proteins and their substrates

Anteghini, M.; Martins dos Santos, V. A. P.; Saccenti, E.

10.1101/2023.01.26.525714 — bioinformatics — Posted on 2023-01-27

576 Adaptation of Graph Convolutional Neural Networks and Graph Layer-wise Relevance Propagation to the Spektral library with application to gene expression data of Colorectal Cancer patients

Lutz, S.; Auer, F. J.; Hartmann, D.; Chereda, H.; Beissbarth, T.; Kramer, F.

10.1101/2023.01.26.525010 — bioinformatics — Posted on 2023-01-27

577 macrosyntR : Drawing automatically ordered Oxford Grids from standard genomic files in R

El Hilali, S.; Copley, R. R.

10.1101/2023.01.26.525673 — bioinformatics — Posted on 2023-01-27

578 The Hidradenitis Suppurativa 'Omics Database (HS-OmicsDB)

Dimitrion, P.; Loveless, I.; Zhou, L.; Mi, Q.-S.; Adrianto, I.

10.1101/2023.01.26.524600 — bioinformatics — Posted on 2023-01-27

579 Deep learning enables fast, gentle STED microscopy

Ebrahimi, V.; Stephan, T.; Kim, J.; Carravilla, P.; Eggeling, C.; Jakobs, S.; Han, K. Y.

10.1101/2023.01.26.525571 — bioengineering — Posted on 2023-01-27

580 Differential patterns of automatic segmentation of 3T and 7T MRI: Implications in neuropsychiatric disease

Verma, G.; Choi, K. S.; Mayberg, H.; Balchandani, P.

10.1101/2023.01.25.525542 — bioengineering — Posted on 2023-01-27

581 The RPA complex orchestrates K63-linked deubiquitination via ZUP1

Foster, B.; Attwood, M.; Chong, K.; Drake, M.; Gilroy, R.; Fournier, M.; Gibbs-Seymour, I.

10.1101/2023.01.27.525918 — biochemistry — Posted on 2023-01-27

582 Sequential restoring O2 then unloading CO2 is beneficial against reperfusion injury: role of CO2 in metabolism

Liu, N.; Wang, L.; Xing, Y.; Wang, C.

10.1101/2023.01.26.525692 — biochemistry — Posted on 2023-01-27

583 Heterogeneous responsiveness to environmental stimuli

Cavailles, J.; Grube, M.; Kuzmics, C.

10.1101/2023.01.26.525694 — animal behavior and cognition — Posted on 2023-01-27

584 Immunoreactivity against SLC3A2 in high grade gliomas displays positive correlation with glioblastoma patient survival: Potential target for glioma diagnosis and therapy

Karakas, N.; Topcu, O.; Tuzun, E.; Timirci Kahraman, O.; Sabanci, P. A.; Aras, Y.; Yetimler, B.; Unverengil, G.; Bilgic, M. B.; Shah, K.; Korkaya, H.

10.1101/2023.01.26.525653 — immunology — Posted on 2023-01-27

585 Homeostatic Reinforcement Theory Accounts for Sodium Appetitive State- and Taste- Dependent Dopamine Responding.

Duriez, A.; Bergerot, C.; Cone, J. J.; Roitman, M. F.; Gutkin, B.

10.1101/2023.01.26.525642 — neuroscience — Posted on 2023-01-27

586 Prediction of brain age using structural magnetic resonance imaging: A comparison of accuracy and test-retest reliability of publicly available software packages

Dorfel, R. P.; Arenas-Gomez, J. M.; Fisher, P. M.; Ganz, M.; Knudsen, G. M.; Svensson, J.; Plaven-Sigray, P.

10.1101/2023.01.26.525514 — neuroscience — Posted on 2023-01-27

587 Excitation energy transfer between higher excited states of photosynthetic pigments: 1. Carotenoids facilitate B -> Q band conversion in chlorophylls

Götze, J. P.; Lokstein, H.

10.1101/2023.01.26.525634 — biophysics — Posted on 2023-01-27

588 Infection of equine bronchial epithelial cells with a SARS-CoV-2 pseudovirus

Legere, R. M.; Allegro, A. R.; Affram, Y.; Petri da Silveira, B.; Fridley, J. L.; Wells, K. M.; Oezguen, N.; Burghardt, R. C.; Wright, G. A.; Pollet, J.; Bordin, A. I.; de Figueiredo, P.; Leibowitz, J. L.; Cohen, N. D.

10.1101/2023.01.26.525770 — microbiology — Posted on 2023-01-27

589 The lung employs an intrinsic surfactant-mediated inflammatory response for viral defense

Leibel, S. L.; McVicar, R. N.; Murad, R.; Kwong, E. M.; Clark, A. E.; Alvarado, A.; Grimmig, B. A.; Nuryyev, R.; Young, R. E.; Lee, J. C.; Peng, W.; Zhu, Y. P.; Griffis, E.; Nowell, C. J.; James, B.; Alarcon, S.; Malhotra, A.; Gearing, L. J.; Hertzog, P. J.; Galapate, C. M.; Galenkamp, K. M. O.; Commisso, C.; Smith, D. M.; Sun, X.; Carlin, A. F.; Croker, B. A.; Snyder, E. Y.

10.1101/2023.01.26.525578 — immunology — Posted on 2023-01-27

590 The Omicron variant BQ.1* with mutations at positions 28,311 and 28,312 in the SARS-CoV-2 N gene have minimal impact on CDC N1 target detection

Ren, G.; Langhorst, B. W.; Patton, G. C.

10.1101/2023.01.26.525759 — biochemistry — Posted on 2023-01-27

591 CompCorona: A Web Portal for Comparative Analysis of the Host Transcriptome of PBMC and Lung SARS-CoV-2, SARS-CoV, and MERS-CoV

Salihoglu, R.; Saracoglu, F.; Sibai, M.; Zengin, T.; Abak Masud, B.; Karasoy, O.; Onal-Suzek, T.

10.1101/2023.01.21.524927 — bioinformatics — Posted on 2023-01-27

592 Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity

Yun, S.; Soler, I.; Tran, F. H.; Haas, H. A.; Shi, R.; Bancroft, G. L.; Suarez, M.; de Santis, C. R.; Raynolds, R. P.; Eisch, A. J.

10.1101/2023.01.26.525756 — animal behavior and cognition — Posted on 2023-01-27

593 An antagonism between Spinophilin and Syd-1 operates upstream of memory promoting presynaptic long-term plasticity

Ramesh, N.; Escher, M.; Turrel, O.; Lützkendorf, J.; Matkovic-Rachid, T.; Liu, F.; Sigrist, S. J.

10.1101/2023.01.24.525468 — neuroscience — Posted on 2023-01-27

594 Antagonistic regulation of salt and sugar chemotaxis plasticity by a single chemosensory neuron in Caenorhabditis elegans

Tomioka, M.; Umemura, Y.; Ueoka, Y.; Chin, R.; Katae, K.; Uchiyama, C.; Ike, Y.; Iino, Y.

10.1101/2023.01.25.525622 — neuroscience — Posted on 2023-01-27

595 Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

Walker, F. M.; Martin Sobral, L.; Danis, E.; Sanford, B.; Balakrishnan, I.; Wang, D.; Pierce, A.; Karam, S. D.; Serkova, N. J.; Foreman, N. K.; Venkataraman, S.; Dowell, R.; Vibhakar, R.; Dahl, N. A.

10.1101/2023.01.24.525424 — cancer biology — Posted on 2023-01-27

596 TCR-pMHC complex formation triggers CD3 dynamics

van Eerden, F. J.; Sherif, A. A.; Covarrubias, M. A. L.; Millius, A.; Lu, X.; Ishizuka, S.; Yamasaki, S.; Standley, D. M.

10.1101/2022.07.27.501668 — molecular biology — Posted on 2023-01-27

597 Tracking subjects' strategies in behavioural choice experiments at trial resolution

Maggi, S.; Hock, R. M.; O'Neill, M.; Buckley, M. J.; Moran, P. M.; Bast, T.; Sami, M.; Humphries, M. D.

10.1101/2022.08.30.505807 — neuroscience — Posted on 2023-01-27

598 Combining modelling and experimental approaches to assess the feasibility of developing rice-oil palm agroforestry system

Perez, R. P. A.; VEZY, R.; Bordon, R.; Laisne, T.; Roques, S.; Rebolledo, M.-C.; Rouan, L.; Fabre, D.; Gibert, O.; de Raissac, M.

10.1101/2022.12.19.521043 — plant biology — Posted on 2023-01-27

599 The Urtica Dioica Agglutinin Prevents Rabies Virus Infection in a Muscle Explant Model

Wang, X.; Terrie, L.; Wu, G.; Damme, E. V.; Fooks, A.; Banyard, A. C.; Thorrez, L.; Jochmans, D.; Neyts, J.

10.1101/2021.05.21.441744 — pathology — Posted on 2023-01-27

600 Joint inference of exclusivity patterns and recurrent trajectories from tumor mutation trees

Luo, X. G.; Kuipers, J.; Beerenwinkel, N.

10.1101/2021.11.04.467347 — cancer biology — Posted on 2023-01-27

601 A Genetic History of Continuity and Mobility in the Iron Age Central Mediterranean

Moots, H. M.; Antonio, M. L.; Sawyer, S.; Spence, J. P.; Oberreiter, V.; Weiss, C. L.; Lucci, M.; Cherifi, Y. M. S.; La Pastina, F.; Genchi, F.; Praxmarer, E.; Zagorc, B.; Cheronet, O.; Özdogan, K. T.; Demetz, L.; Amrani, S.; Candilio, F.; De Angelis, D.; Gasperetti, G.; Fernandes, D.; Gao, Z.; Fantar, M.; Coppa, A.; Pritchard, J. K.; Pinhasi, R.

10.1101/2022.03.13.483276 — genomics — Posted on 2023-01-27

602 Adolescent length growth spurts in bonobos and other primates: Mind the scale

Berghaenel, A.; Stevens, J. M. G.; Hohmann, G.; Deschner, T.; Behringer, V.

10.1101/2023.01.26.525764 — evolutionary biology — Posted on 2023-01-26

603 Fetal exposure to endocrine disrupting-bisphenol A (BPA) alters testicular fatty acid metabolism in the adult offspring: relevance to sperm maturation and quality

Varma, S.; Molangiri, A.; Kona, S. R.; Ibrahim, A.; Duttaroy, A. K.; Basak, S.

10.1101/2023.01.18.524658 — developmental biology — Posted on 2023-01-27

604 Intonation Units in spontaneous speech evoke a neural response

Inbar, M.; Genzer, S.; Perry, A.; Grossman, E.; Landau, A. N.

10.1101/2023.01.26.525707 — neuroscience — Posted on 2023-01-26

605 Analysis of convolutional neural networks reveals the computational properties essential for subcortical processing of facial expression

Lim, C.; Inagaki, M.; Shinozaki, T.; Fujita, I.

10.1101/2023.01.18.524656 — neuroscience — Posted on 2023-01-26

606 Summary tests of introgression are highly sensitive to rate variation across lineages

Frankel, L. E.; Ane, C.

10.1101/2023.01.26.525396 — evolutionary biology — Posted on 2023-01-26

607 Aminobenzoic acid derivatives obstruct induced fit in the catalytic center of the ribosome

Majumdar, C.; Walker, J. A.; Francis, M. B.; Schepartz, A.; Cate, J. H. D.

10.1101/2023.01.25.525534 — biophysics — Posted on 2023-01-26

608 Microbiome structure of a wild Drosophila community along tropical elevational gradients and comparison to laboratory lines

Brown, J. J.; Jandova, A.; Jeffs, C. T.; Higgie, M.; Novakova, E.; Lewis, O. T.; Hrcek, J.

10.1101/2021.07.28.454263 — ecology — Posted on 2023-01-26

609 EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

Chakraborty, S.; Bhat, A. M.; Mushtaq, I.; Luan, H.; Kalluchi, A.; Mirza, S.; Storck, M. D.; Chaturvedi, N.; Lopez-Guerrero, J. A.; Llombart-Bosch, A.; Machado, I.; Meza, J. L.; Ghosal, G.; Coulter, D. W.; Rowley, J. M.; Band, V.; Mohapatra, B. C.; Band, H.

10.1101/2023.01.15.524130 — cancer biology — Posted on 2023-01-26

610 A simple image processing pipeline to sharpen topology maps in multi-wavelength interference microscopy

Tinning, P. W.; Schniete, J. K.; Scrimgeour, R. C.; Koelln, L. S.; Rooney, L. M.; Bushell, T. J.; McConnell, G.

10.1101/2023.01.12.523706 — biophysics — Posted on 2023-01-26

611 Nucleation of Biomolecular Condensates from Finite-Sized Simulations

Li, L.; Paloni, M.; Finney, A. R.; Barducci, A.; Salvalaglio, M.

10.1101/2022.11.11.515961 — biophysics — Posted on 2023-01-26

612 Small immunological clocks identified by Deep Learning and Gradient Boosting

Kalyakulina, A.; Yusipov, I.; Kondakova, E.; Bacalini, M. G.; Franceschi, C.; Vedunova, M.; Ivanchenko, M.

10.1101/2022.10.28.514283 — bioinformatics — Posted on 2023-01-26

613 DISCO: A deep learning ensemble for uncertainty-aware segmentation of acoustic signals

Colligan, T.; Irish, K.; Emlen, D. J.; Wheeler, T. J.

10.1101/2023.01.24.525459 — bioinformatics — Posted on 2023-01-26

614 Can the Insect Path Integration Memory be a Bump Attractor?

Pisokas, I.; Kudryashova, N.; Hennig, M. H.

10.1101/2022.04.05.487126 — animal behavior and cognition — Posted on 2023-01-26

615 A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line.

Venuto, A.; Thibodeau-Beganny, S.; Trapani, J. G.; Erickson, T.

10.1101/2023.01.12.523756 — animal behavior and cognition — Posted on 2023-01-26

616 Size and composition of haplotype reference panels impact the accuracy of imputation from low-pass sequencing in cattle

Lloret-Villas, A.; Pausch, H.; Leonard, A. S.

10.1101/2023.01.13.523894 — genomics — Posted on 2023-01-26

617 A high throughput method for egg size measurement in Drosophila

barghi, n.; Ramirez-Lanzas, C.

10.1101/2022.09.13.507758 — evolutionary biology — Posted on 2023-01-26

618 Mutational scans reveal differential evolvability of Drosophila promoters and enhancers

Li, X. C.; Fuqua, T.; van Breugel, M. E.; Crocker, J.

10.1101/2022.10.17.512533 — evolutionary biology — Posted on 2023-01-26

619 Predictive ability of climate on vital rates and population dynamics depends on vital rate and model complexity

Compagnoni, A.; Knight, T. M.; Childs, D.; Salguero-Gomez, R.

10.1101/2022.03.11.484031 — ecology — Posted on 2023-01-26

620 Characterizing insect communities within thin-soil environments

McNamara Manning, K.; Perry, K. I.; Bahlai, C.

10.1101/2022.10.01.510429 — ecology — Posted on 2023-01-26

621 Persistent confined migration confers permanent nuclear and functional changes in migrating cells.

de Lope-Planelles, A.; Gonzalez-Novo, R.; Madrazo, E.; Zamora-Carreras, H.; Torrano, V.; Lopez-Menendez, H.; Roda-Navarro, P.; Monroy, F.; Redondo-Munoz, J.

10.1101/2023.01.05.522838 — cell biology — Posted on 2023-01-26

622 An RNA-based feed-forward mechanism ensures motor switching in oskar mRNA transport

Gaspar, I.; Phea, L. J.; McClintock, M. A.; Heber, S.; Bullock, S. L.; Ephrussi, A.

10.1101/2021.04.24.441269 — cell biology — Posted on 2023-01-26

623 Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner

Fu, X.; Zhuang, Q.; Babarinde, I. A.; Shi, L.; Ma, G.; Hu, H.; Li, Y.; Chen, J.; Xiao, Z.; Deng, B.; Sun, L.; Jauch, R.; Hutchins, A.

10.1101/2022.12.01.518778 — cell biology — Posted on 2023-01-26

624 Staphylococcus aureus prophages are gatekeepers of lipid utilization to control membrane plasticity, bacterial fitness, and antibiotic adaptation

Zhou, B.; Pathania, A.; Pant, D.; Halpern, D.; Gaudu, P.; Trieu-Cuot, P.; Gruss, A.; Gloux, K.

10.1101/2022.01.27.478126 — microbiology — Posted on 2023-01-26

625 Enterococcus faecalis strains with compromised CRISPR-Cas defense emerge under antibiotic selection for a CRISPR-targeted plasmid

Huo, W.; Price, V. J.; Sharifi, A.; Zhang, M. Q.; Palmer, K. L.

10.1101/220467 — microbiology — Posted on 2023-01-26

626 Unravelling specific diet and gut microbial contributions to inflammatory bowel disease

Vasconcelos Pereira, G.; Boudaud, M.; Wolter, M.; Alexander, C.; De Sciscio, A.; Grant, E.; Caetano Trindade, B.; Singh, S.; Campbell, A.; Pudlo, N.; Willieme, S.; Craig, S.; Kim, K.; Denike-Duval, T.; Kennedy, L.; Schmidt, T.; Chen, G.; Eaton, K.; Desai, M. S.; Martens, E. C.

10.1101/2022.04.03.486886 — microbiology — Posted on 2023-01-26

627 Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles

Wang, H.; Wang, Y.; Yuan, C.; Xu, X.; Zhou, W.; Huang, Y.; Lu, H.; Zheng, Y.; Luo, G.; Shang, J.; Sui, M.

10.1101/2022.11.24.516986 — immunology — Posted on 2023-01-26

628 Reproducible patterns of neural activity without attractors in cortical networks

Guarino, D.; Filipchuk, A.; Destexhe, A.

10.1101/2022.05.24.493230 — neuroscience — Posted on 2023-01-26

629 Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr682 phosphorylated APP βCTF

Im, E.; Jiang, Y.; Stavrides, P.; Darji, S.; Erdjument-Bromage, H.; Neubert, T.; Choi, J. Y.; Wegiel, J.; Lee, J.-H.; Nixon, R.

10.1101/2022.06.02.494546 — neuroscience — Posted on 2023-01-26

630 Temporal asymmetries and interactions between dorsal and ventral visual pathways during object recognition

Ayzenberg, V.; Simmons, C.; Behrmann, M.

10.1101/2022.09.17.508376 — neuroscience — Posted on 2023-01-26

631 EEG and pupillometric signatures of working memory overload

Kosachenko, A. I.; Kasanov, D.; Kotyusov, A. I.; Pavlov, Y. G.

10.1101/2022.11.21.517347 — neuroscience — Posted on 2023-01-26

632 Organotopic organization of the cervical vagus nerve

Thompson, N.; Ravagli, E.; Mastitskaya, S.; Iacoviello, F.; Stathopoulou, T.-R.; Perkins, J.; Shearing, P. R.; Aristovich, K.; Holder, D.

10.1101/2022.02.24.481810 — neuroscience — Posted on 2023-01-26

633 Perinatal High Fat Diet Exposure Alters Oxytocin and Corticotropin Releasing Factor Inputs onto Vagal Neurocircuits Controlling Gastric Motility

Carson, K. E.; Alvarez, J.; Mackley, J.; Travagli, A.; Browning, K. N.

10.1101/2022.11.28.517564 — neuroscience — Posted on 2023-01-26

634 5-HT1A and 5-HT2B receptor interaction and co-clustering regulates serotonergic neuron excitability

Benhadda, A.; Delhaye, C.; Moutkine, I.; Marques, X.; Russeau, M.; Le Magueresse, C.; Roumier, A.; Levi, S.; Maroteaux, L.

10.1101/2022.12.09.519723 — neuroscience — Posted on 2023-01-26

635 Evaluation of Long-Short Term Memory Networks for M/EEG Source Imaging with Simulated and Real EEG Data

Hecker, L.; Maschke, M.; Rupprecht, R.; Tebartz van Elst, L.; Kornmeier, J.

10.1101/2022.04.13.488148 — neuroscience — Posted on 2023-01-26

636 The rubber tree kinome: genome-wide characterization and insights into coexpression patterns associated with abiotic stress responses

Santos, L. B.; Aono, A. H.; Francisco, F. R.; Silva, C. C.; Souza, L. M.; de Souza, A. P.

10.1101/2022.08.24.505065 — plant biology — Posted on 2023-01-26

637 Analysis of the Hamiltonian Monte Carlo genotyping algorithm on PROVEDIt mixtures including a novel precision benchmark

Susik, M.; Sbalzarini, I. F.

10.1101/2022.08.28.505600 — bioinformatics — Posted on 2023-01-26

638 Midi-metagenomics: A novel approach for cultivation independent microbial genome reconstruction from environmental samples

Vollmers, J.; Correa Cassal, M.; Kaster, A.-K.

10.1101/2023.01.26.525644 — genomics — Posted on 2023-01-26

639 Impact of cell size on morphogen gradient precision

Adelmann, J. A.; Vetter, R.; Iber, D.

10.1101/2022.02.02.478800 — developmental biology — Posted on 2023-01-26

640 Histone-organized chromatin in bacteria

Hocher, A.; Laursen, S.; Radford, P.; Tyson, J.; Lambert, C.; Stevens, K. M.; Picardeau, M.; Sockett, R. E.; Luger, K.; Warnecke, T.

10.1101/2023.01.26.525422 — molecular biology — Posted on 2023-01-26

641 Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex

Wan, M. S. M.; Muhammad, R.; Koliopoulos, M. G.; Roumeliotis, T. I.; Chaudhary, J. S.; Alfieri, C.

10.1101/2023.01.26.525585 — molecular biology — Posted on 2023-01-26

642 miR-7 controls glutamatergic transmission and neuronal connectivity in a Cdr1as-dependent manner

Cerda-Jara, C. A.; Kim, S. J.; Thomas, G.; Farsi, Z.; Zolotarov, G.; Georgii, E.; Woehler, A.; Piwecka, M.; Rajewsky, N.

10.1101/2023.01.26.525729 — molecular biology — Posted on 2023-01-26

643 Insights into polyprotein processing and RNA-protein interactions in foot-and-mouth disease virus genome replication.

Pierce, D. M.; Rowlands, D.; Stonehouse, N. J.; Herod, M. R.

10.1101/2023.01.26.525530 — microbiology — Posted on 2023-01-26

644 The respiratory syncytial virus surge in Austria, 2022, was caused by lineages present before the COVID-19 pandemic

Redlberger-Fritz, M.; Springer, D. N.; Aberle, S. W.; Camp, J. V.; Aberle, J. H.

10.1101/2023.01.26.525650 — microbiology — Posted on 2023-01-26

645 Helminth-derived metabolites induce tolerogenic functional, metabolic, and transcriptional signatures in dendritic cells that attenuate experimental colitis

Malacco, N. L.; Michi, A. N.; Siciliani, E.; Madrigal, A. G.; Sternlieb, T.; Fontes, G.; King, I. L.; Cestari, I.; Jardim, A.; Stevenson, M. M.; Lopes, F.

10.1101/2023.01.26.525718 — immunology — Posted on 2023-01-26

646 IL-4 downregulates BCL6 to promote memory B cell selection in germinal centers

Shehata, L.; Thouvenel, C. D.; Hondowicz, B. D.; Pew, L. A.; Rawlings, D. J.; Choi, J.; Pepper, M.

10.1101/2023.01.26.525749 — immunology — Posted on 2023-01-26

647 Mapping a brain parasite: occurrence and spatial distribution in fish encephalon

Born-Torrijos, A.; van Beest, G. S.; Merella, P.; Garippa, G.; Raga, J. A.; Montero, F. E.

10.1101/2023.01.26.525646 — zoology — Posted on 2023-01-26

648 Prevalence of Bovine Cysticercosis, Human Taeniasis and Associated Risk Factors in Selected Towns of Silte Zone, Southern Ethiopia

Mussa, S. M.

10.1101/2023.01.25.525623 — systems biology — Posted on 2023-01-26

649 Homeostasis at different backgrounds: The roles of overlayed feedback structures in vertebrate photoadaptation

Grini, J. V.; Nygard, M.; Ruoff, P.

10.1101/2023.01.25.525568 — systems biology — Posted on 2023-01-26

650 HOS1 promotes plant tolerance to low-energy stress via the SnRK1 protein kinase

Margalha, L.; Elias, A.; Belda-Palazon, B.; Peixoto, B.; Confraria, A.; Baena-Gonzalez, E.

10.1101/2023.01.26.525711 — plant biology — Posted on 2023-01-26

651 A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments

Chidley, C.; Darnell, A. M.; Gaudio, B. L.; Lien, E. C.; Barbeau, A. M.; Vander Heiden, M. G.; Sorger, P. K.

10.1101/2023.01.26.525375 — cancer biology — Posted on 2023-01-26

652 Single-molecule displacement mapping unveils sign-asymmetric protein charge effects on intraorganellar diffusion

Xiang, L.; Yan, R.; Chen, K.; Li, W.; Xu, K.

10.1101/2023.01.26.525611 — biophysics — Posted on 2023-01-26

653 Two conformations of the Tom20 preprotein receptor in the TOM holo complex

Ornelas, P.; Bausewein, T.; Martin, J.; Morgner, N.; Nussberger, S.; Kuehlbrandt, W.

10.1101/2023.01.26.525638 — biophysics — Posted on 2023-01-26

654 Single-molecule displacement mapping indicates unhindered intracellular diffusion of small (<~1 kDa) solutes

Choi, A. A.; Xiang, L.; Li, W.; Xu, K.

10.1101/2023.01.26.525579 — biophysics — Posted on 2023-01-26

655 Assembly properties of Spiroplasma MreB involved in swimming motility

Takahashi, D.; Miyata, M.; Fujiwara, I.

10.1101/2023.01.26.525654 — biophysics — Posted on 2023-01-26

656 Preparation and Characterization of Inactivated Tick-Borne Encephalitis Virus Samples for Single Particle Imaging at European XFEL

Vorovitch, M. F.; Samygina, V. R.; Pichkur, E.; Konarev, P. V.; Peters, G.; Khvatov, E. V.; Ivanova, A. L.; Tuchynskaya, K. K.; Konyushko, O. I.; Fedotov, A. Y.; Armeev, G.; Shaytan, K. V.; Maia, F. R. N. C.; Kovalchuk, M. V.; Osolodkin, D. I.; Ishmukhametov, A. A.; Egorov, A. M.

10.1101/2023.01.26.525647 — biophysics — Posted on 2023-01-26

657 Collective heterogeneity of mitochondrial potential in contact inhibition of proliferation

Thurakkal, B.; Hari, K.; Marwaha, R.; Karki, S.; Jolly, M. K.; Das, T.

10.1101/2023.01.25.525600 — biophysics — Posted on 2023-01-26

658 SPEAR: a Sparse Supervised Bayesian Factor Model for Multi-omic Integration

Gygi, J. P.; Konstorum, A.; Pawar, S.; Kleinstein, S. H.; Guan, L.

10.1101/2023.01.25.525545 — bioinformatics — Posted on 2023-01-26

659 Biochemical Properties of Naturally Occurring Human Bloom Helicase Variants

Cueny, R. R.; Varma, S.; Schmidt, K. H.; Keck, J. L.

10.1101/2023.01.26.525669 — biochemistry — Posted on 2023-01-26

660 Simulation-based future-oriented strategy can optimize decision making in a breeding program

Hamazaki, K.; Iwata, H.

10.1101/2023.01.25.525616 — genomics — Posted on 2023-01-26

661 Clonal cell states link Barrett's esophagus and esophageal adenocarcinoma

Gier, R. A.; Hueros, R. A. R.; Rong, J.; DeMarshall, M.; Karakasheva, T. A.; Muir, A. B.; Falk, G. W.; Zhang, N. R.; Shaffer, S. M.

10.1101/2023.01.26.525564 — genomics — Posted on 2023-01-26

662 The Glucocorticoid Receptor is Required for Efficient Aldosterone-Induced Transcription by the Mineralocorticoid Receptor

Johnson, T. A.; Fettweis, G.; Wagh, K.; Almeida-Prieto, B.; Hager, G. L.; Alvarez de la Rosa, D.

10.1101/2023.01.26.525745 — molecular biology — Posted on 2023-01-26

663 HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

Monda, J. K.; Ge, X.; Hunkeler, M.; Donovan, K. A.; Ma, M. W.; Jin, C. Y.; Leonard, M.; Fischer, E. S.; Bennett, E. J.

10.1101/2023.01.26.525555 — molecular biology — Posted on 2023-01-26

664 The evolution of binding affinities between p53 and MDM2 across the animal kingdom demonstrates high plasticity in motif-mediated interactions

Mihalic, F.; Aberg, E.; Farkhondehkish, P.; Theys, N.; Andersson, E.; Jemth, P.

10.1101/2023.01.26.525693 — molecular biology — Posted on 2023-01-26

665 Oriented Display of Cello-Oligosaccharides for Pull-down Binding Assays to Distinguish Binding Preferences of Glycan Binding Proteins

Hackl, M.; Power, Z.; Chundawat, S. P. S.

10.1101/2023.01.26.525732 — molecular biology — Posted on 2023-01-26

666 Contrasting drivers of abundant phage and prokaryotic communities in tropical, coastal ecosystems across the Isthmus of Panama

Weinheimer, A. R.; Aylward, F. O.; Leray, M.; Scott, J. J.

10.1101/2023.01.26.525695 — microbiology — Posted on 2023-01-26

667 Gallionellaceae pangenomic analysis reveals insight into phylogeny, metabolic flexibility, and iron oxidation mechanisms

Hoover, R. L.; Keffer, J. L.; Polson, S. W.; Chan, C. S.

10.1101/2023.01.26.525709 — microbiology — Posted on 2023-01-26

668 Microbial stir bars: light activated rotation of tethered bacterial cells to enhance mixing in stagnant fluids.

Gurung, J. P.; Kashani, M. N.; de Silva, C. M.; Baker, M. A.

10.1101/2023.01.26.525760 — microbiology — Posted on 2023-01-26

669 Export of diverse and bioactive peptides through a type I secretion system.

Kim, S.-Y.; Parker, J. K.; Gonzalez-Magaldi, M.; Telford, M. S.; Leahy, D. J.; Davies, B. W.

10.1101/2023.01.26.525739 — microbiology — Posted on 2023-01-26

670 Host cell cAMP-Epac pathway inhibition by hawthorn extract as a potential treatment for Chagas disease

Ferri, G.; Fernandez, L. R.; Di Mario, G. T.; Palermo, J. A.; Edreira, M. M.

10.1101/2023.01.26.525677 — microbiology — Posted on 2023-01-26

671 Astrocytic connection to engram neurons increased after learning

Kim, J.; Sung, Y.; Park, H.; Choi, D. I.; Kim, J.-i.; Lee, H.; Jung, M. K.; Noh, S.; Ye, S.; Lee, J.; Islam, M. A.; Chun, H.; Mun, J. Y.; Kaang, B.-K.

10.1101/2023.01.25.525617 — neuroscience — Posted on 2023-01-26

672 Using mechanistic models and machine learning to design single-color multiplexed Nascent Chain Tracking experiments

Raymond, W. S.; Ghaffari, S.; Aguilera de Lira, L. U.; Ron, E.; Morisaki, T.; Fox, Z. R.; May, M. P.; Stasevich, T. S.; Munsky, B.

10.1101/2023.01.25.525583 — systems biology — Posted on 2023-01-26

673 Effect of selective end-to-end base stacking interactions on the stability of smectic liquid crystal ordering in concentrated gapped DNA solutions

Kodikara, S. G.; Gyawali, P.; Gleeson, J.; Jakli, A.; Sprunt, S.; Balci, H.

10.1101/2023.01.25.525591 — biophysics — Posted on 2023-01-26

674 A deep learning approach for the discovery of tumor-targeting small organic ligands from DNA-Encoded Chemical Libraries

Torng, W.; Biancofiore, I.; Oehler, S.; Xu, J.; Xu, J.; Watson, I.; Masina, B.; Prati, L.; Favalli, N.; Bassi, G.; Neri, D.; Cazzamalli, S.; Feng, J. A.

10.1101/2023.01.25.525453 — bioinformatics — Posted on 2023-01-26

675 Strain Tracking with Uncertainty Quantification

Kim, Y.; Worby, C. J.; Acharya, S.; van Dijk, L. R.; Alfonsetti, D.; Gromko, Z. J.; Azimzadeh, P. N.; Dodson, K. W.; Gerber, G. K.; Hultgren, S. J.; Earl, A. M.; Berger, B.; Gibson, T. E.

10.1101/2023.01.25.525531 — bioinformatics — Posted on 2023-01-26

676 Molecular Jackhammers Eradicate Cancer Cells by Vibronic-Driven Action

Ayala-Orozco, C.; Galvez-Aranda, D.; Corona, A.; Seminario, J. M.; Rangel, R.; Myers, J. N.; Tour, J. M.

10.1101/2023.01.25.525400 — bioengineering — Posted on 2023-01-26

677 Contribution of circulating host and microbial tryptophan metabolites towards Ah receptor activation

Morgan, E. W.; Dong, F.; Annalora, A.; Murray, I. A.; Wolfe, T.; Erickson, R.; Gowda, K.; Amin, S. G.; Petersen, K. S.; Kris-Etherton, P. M.; Marcus, C.; Walk, S. T.; Patterson, A. D.; Perdew, G. H.

10.1101/2023.01.26.525691 — biochemistry — Posted on 2023-01-26

678 CRaTER enrichment for on-target gene-editing enables generation of variant libraries in hiPSCs

Friedman, C. E.; Fayer, S.; Pendyala, S.; Chien, W.-M.; Tran, L.; Chao, L.; McKinstry, A.; Karbassi, E.; Fenix, A. M.; Loiben, A.; Murry, C. E.; Starita, L. M.; Fowler, D. M.; Yang, K.-C.

10.1101/2023.01.25.525582 — genetics — Posted on 2023-01-26

679 Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection

Keller, N. P.; Schoen, T. J.; Calise, D. G.; Bok, J. W.; Nwagwu, C. D.; Zarnowski, R.; Andes, D.; Huttenlocher, A.

10.1101/2023.01.25.525624 — microbiology — Posted on 2023-01-26

680 Bayesian modeling of the impact of antibiotic resistance on the efficiency MRSA decolonization

Ojala, F.; Sater, M. R. A.; Miller, L. G.; McKinnell, J. A.; Huang, S. S.; Grad, Y. H.; Marttinen, P.

10.1101/2023.01.25.525621 — microbiology — Posted on 2023-01-26

681 Identification and characterization of an HtrA sheddase produced by Coxiella burnetii

OSMAN, I. O.; Caputo, A.; PINAULT, L.; Mege, J.-L.; LEVASSEUR, A.; Devaux, C. A.

10.1101/2023.01.26.525556 — microbiology — Posted on 2023-01-26

682 First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS)

Jhelum, H.; Grand, N.; Jacobsen, K. R.; Halecker, S.; Salerno, M.; Prate, R.; Krüger, L.; Kristiansen, Y.; Krabben, L.; Möller, L.; Laue, M.; Kaufer, B.; Denner, J.

10.1101/2023.01.26.525667 — microbiology — Posted on 2023-01-26

683 Item-specific memory reactivation supports overnight memory consolidation

Liu, J.; Xia, T.; Chen, D.; Yao, Z.; Zhu, M.; Antony, J. W.; Lee, T. M.; Hu, X.

10.1101/2023.01.25.525599 — neuroscience — Posted on 2023-01-26

684 adgrl3.1-deficient zebrafish show noradrenaline-mediated externalizing behaviors, and altered expression of externalizing disorder-candidate genes, suggesting functional targets for treatment

Fontana, B. D.; Reichmann, F.; Tilley, C. A.; Lavlou, P.; Shkumatava, A.; Alnassar, N.; Hillman, C.; Karlsson, K. A.; Norton, W. H. J.; Parker, M. O.

10.1101/2023.01.25.525492 — neuroscience — Posted on 2023-01-26

685 Lost in space(s): multimodal neuroimaging of disorientation along the Alzheimer's disease continuum

Peters-Founshtein, G.; Gazit, L.; Naveh, T.; Domachevsky, L.; Korczyn, A.; Bernstine, H.; Groshar, D.; Marshall, G.; Arzy, S.

10.1101/2023.01.25.525587 — neuroscience — Posted on 2023-01-26

686 Atypical cognitive training-induced learning and brain plasticity and their relation to insistence on sameness in children with autism

Liu, J.; Chang, H.; Abrams, D. A.; Kang, J. B.; Chen, L.; Rosenberg-Lee, M.; Menon, V.

10.1101/2023.01.25.525594 — neuroscience — Posted on 2023-01-26

687 Identification of Immune-Related Candidate Biomarkers in Plasma of Patients with Sporadic Vestibular Schwannoma

Vasilijic, S.; Atai, N.; Hyakusoku, H.; Worthington, S.; Ren, Y.; Sagers, J. E.; Sahin, M. I.; Fujita, T.; Landegger, L. D.; Lewis, R.; Welling, B. D.; Stankovic, K. M.

10.1101/2023.01.24.525436 — neuroscience — Posted on 2023-01-26

688 Lifelong olfactory deprivation-dependent cortical reorganization restricted to orbitofrontal cortex

Peter, M. G.; Darki, F.; Thunell, E.; Martensson, G.; Postma, E. M.; Boesveldt, S.; Westman, E.; Lundstrom, J. N.

10.1101/2023.01.25.525521 — neuroscience — Posted on 2023-01-26

689 Increments in Visual Motion Coherence are More Readily Detected than Decrements

Wei, L.; Mitchell, A. O.; Maunsell, J. H. R.

10.1101/2023.01.25.525590 — neuroscience — Posted on 2023-01-26

690 Gigantic Macroraptorial Sperm Whale Tooth (cf. Livyatan) from the Miocene of Orange County, California

Watmore, K. I.; Prothero, D. R.

10.1101/2023.01.25.525567 — paleontology — Posted on 2023-01-26

691 TERT expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entities

Kuhn, C. K.; Meister, J.; Kreft, S.; Stiller, M.; Puppel, S.-H.; Zaremba, A.; Scheffler, B.; Ullrich, V.; Schöneberg, T.; Schadendorf, D.; Horn, S.

10.1101/2023.01.25.525565 — cancer biology — Posted on 2023-01-26

692 An intrinsically interpretable neural network architecture for sequence to function learning

Balci, A. T.; Ebeid, M. M.; Benos, P. V.; Kostka, D.; Chikina, M.

10.1101/2023.01.25.525572 — bioinformatics — Posted on 2023-01-26

693 Quantum mechanical electronic and geometric parameters for DNA k-mers as features for machine learning

Masuda, K.; Abdullah, A. A.; Sahakyan, A. B.

10.1101/2023.01.25.525597 — bioinformatics — Posted on 2023-01-26

694 Adjustments to the reference dataset design improves cell type label transfer

Moelbert, C.; Haghverdi, L.

10.1101/2023.01.25.525533 — bioinformatics — Posted on 2023-01-26

695 A targeted isotope dilution mass spectrometry assay for Osteopontin quantification in plasma of metastatic breast cancer patients

Leslie, A.; Teh, E.; Drucker, A.; Pinto, D. M.

10.1101/2023.01.25.525566 — biochemistry — Posted on 2023-01-26

696 Statistical evaluation of character support reveals the instability of higher-level dinosaur phylogeny

Cerny, D.; Simonoff, A. L.

10.1101/2023.01.25.525612 — evolutionary biology — Posted on 2023-01-26

697 Extensive hybridisation between multiple differently adapted species may aid persistence in a changing climate

Satokangas, I.; Nouhaud, P.; Seifert, B.; Punttila, P.; Schultz, R.; Jones, M.; Siren, J.; Helantera, H.; Kulmuni, J.

10.1101/2023.01.25.525480 — evolutionary biology — Posted on 2023-01-26

698 One marine protected area is not enough: The trophic ecology of the broadnose sevengill shark (Notorynchus cepedianus) in the Southwest Atlantic

Funes, M.; De Wysiecki, A. M.; Bovcon, N. D.; Jaureguizar, A. J.; Irigoyen, A. J.

10.1101/2023.01.25.524777 — ecology — Posted on 2023-01-26

699 Assessment of treatment-specific tethering survival bias for the juvenile blue crab Callinectes sapidus in a simulated salt marsh

Miller, C. R.; Hyman, A. C.; Shi, D. H.; Lipcius, R.

10.1101/2023.01.25.525559 — ecology — Posted on 2023-01-26

700 Exposure to oxacillin subinhibitory concentrations and in vitro induction of resistance expression in heteroresistant and non-heteroresistant oxacillin-susceptible mecA-positive Staphylococcus aureus (OS-MRSA)

Povoa, H. C. C.; Schimidt, D. B.

10.1101/2023.01.24.521449 — microbiology — Posted on 2023-01-26

701 Activated Sludge Microbial Community Assembly: The Role of Influent Microbial Community Immigration

Gibson, C.; Jauffur, S.; Guo, B.; Frigon, D.

10.1101/2023.01.25.525574 — microbiology — Posted on 2023-01-26

702 Patterns of within-host spread of Chlamydia trachomatis between vagina, endocervix and rectum revealed by comparative genomic analysis

Joseph, S. J.; Bommona, S.; Ziklo, N.; Kama, M.; Dean, D.; Read, T. D.

10.1101/2023.01.25.525576 — microbiology — Posted on 2023-01-26

703 Characterizing the microbiome of patients with myeloproliferative neoplasms during a Mediterranean diet intervention

Avelar-Barragan, J.; Mendez Luque, L. F.; Nguyen, J.; Nguyen, H.; Odegaard, A. O.; Fleischman, A. G.; Whiteson, K.

10.1101/2023.01.25.525620 — microbiology — Posted on 2023-01-26

704 The infectious salmon anaemia virus esterase prunes erythrocyte surfaces in infected Atlantic salmon and exposes terminal sialic acids to lectin recognition

Fosse, J. H.; Andresen, A. M. S.; Ploss, F. B.; Weli, S. C.; Heffernan, I.; Sapotka, S.; Lundgard, K.; Kuiper, R. V.; Solhaug, A.; Falk, K.

10.1101/2023.01.25.525626 — microbiology — Posted on 2023-01-26

705 Resting-state fMRI signals contain spectral signatures of local hemodynamic response timing

Bailes, S. M.; Gomez, D. E. P.; Setzer, B.; Lewis, L. D.

10.1101/2023.01.25.525528 — neuroscience — Posted on 2023-01-26

706 Remapping in a recurrent neural network model of navigation and context inference

Low, I. I.; Giocomo, L. M.; Williams, A. H.

10.1101/2023.01.25.525596 — neuroscience — Posted on 2023-01-26

707 Cleavable crosslinkers redefined by novel MS3-trigger algorithm

Kolbowski, L.; Fischer, L.; Rappsilber, J.

10.1101/2023.01.26.525676 — bioinformatics — Posted on 2023-01-26

708 Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

Collins, B.; McConville, C.; Palmer, C.; Schaffitzel, C.; Stroud, D.; Moody, E.; Derivery, E.; Berger, I.; Ross, J.; Sacharz, J.; Chen, K.-E.; Heesom, K.; McNally, K.; Kato, K.; Healy, M.; Chilton, M.; Caruana, N.; Cullen, P.; Ghai, R.; Butkovic, R.; Hall, R.; Yadav, S.; Saitoh, S.; Shaw, S.; Nguyen, T.; Williams, T.; Croll, T.; Borucu, U.; Planelles-Herrero, V.

10.1101/2023.01.25.525455 — biochemistry — Posted on 2023-01-26

709 KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors

Zhang, B.; Zhao, C.; Shen, W.; Li, W.; Zheng, Y.; Kong, X.; Wang, J.; Wu, X.; Liu, Y.; Zhou, Y.

10.1101/2023.01.26.525636 — developmental biology — Posted on 2023-01-26

710 Wengen, a Tumour Necrosis Factor Receptor, regulates the Fibroblast Growth Factor pathway by an unconventional mechanism

Letizia, A.; Espinas, M. L.; llimargas, M.

10.1101/2023.01.26.525651 — developmental biology — Posted on 2023-01-26

711 scRNAseq unravels the transcriptional network underlying zebrafish retina regeneration

Celotto, L.; Rost, F.; Machate, A.; Bläsche, J.; Dahl, A.; Weber, A.; Hans, S.; Brand, M.

10.1101/2023.01.26.525679 — developmental biology — Posted on 2023-01-26

712 Ensemble Processing and Synthetic Image Generation For Abnormally Shaped Nuclei Segmentation

Han, Y.; Lei, Y.; Shkolnikov, V.; Xin, D.; Auduong, A.; Barcelo, S.; Delp, E. J.

10.1101/2023.01.25.525536 — cell biology — Posted on 2023-01-26

713 Wingless signaling promotes lipid mobilization through signal-induced transcriptional repression

Liu, M.; Hemba-Waduge, R.-U.-S.; Li, X.; Huang, X.; Liu, T.-H.; Han, X.; Wang, Y.; Ji, J.-y.

10.1101/2023.01.25.525602 — cell biology — Posted on 2023-01-26

714 Label-Free Mammalian Cell Tracking Enhanced by Precomputed Velocity Fields

Han, Y.; Yang, L.; Shkolnikov, V.; Xin, D.; Barcelo, S.; Allebach, J.; Delp, E.

10.1101/2023.01.25.525598 — cell biology — Posted on 2023-01-26

715 The actin depolymerizing factor StADF2 alters StREM1.3 plasma membrane nanodomains to inhibit the Potato Virus X

Jolivet, M.-D.; Gouguet, P.; Legrand, A.; Xhelilaj, K.; Faiss, N.; Massoni-Laporte, A.; Robbe, T.; Sagot, I.; Boudsocq, M.; German-Retana, S.; Üstün, S.; Loquet, A.; Habenstein, B.; Germain, V.; Mongrand, S.; Gronnier, J.

10.1101/2023.01.25.525625 — cell biology — Posted on 2023-01-26

716 Rapid and Highly Efficient Morphogenic Gene-Mediated Hexaploid Wheat Transformation

Johnson, K.; Chu, U. C.; Anthony, G.; Wu, E.; Che, P.; Jones, T. J.

10.1101/2023.01.25.525570 — plant biology — Posted on 2023-01-26

717 LY6E protects mice from pathogenic effects of murine coronavirus and SARS-CoV-2

Mar, K. B.; Van Dyke, M. C.; Lopez, A. H.; Eitson, J. L.; Fan, W.; Hanners, N. W.; Evers, B. M.; Shelton, J. M.; Schoggins, J. W.

10.1101/2023.01.25.525551 — microbiology — Posted on 2023-01-26

718 Rapid engineering of SARS-CoV-2 therapeutic antibodies to increase breadth of neutralization including XBB.1.5 and BQ.1.1

Entzminger, K. C.; Fleming, J. K.; Entzminger, P. D.; Espinosa, L. Y.; Samadi, A.; Hiramoto, Y.; Okumura, C.; Maruyama, T.

10.1101/2023.01.25.525589 — immunology — Posted on 2023-01-26

719 New tools to study the interaction between integrins and latent TGFbeta1

Bachmann, M.; Kessler, J.; Burri, E.; Wehrle-Haller, B.

10.1101/2023.01.26.525682 — cell biology — Posted on 2023-01-26

720 Polygenic adaptation dynamics in large, finite populations

Devi, A.; Jain, K.

10.1101/2023.01.25.525607 — evolutionary biology — Posted on 2023-01-26

721 Hacking brain development to test models of sensory coding

Ahmed, M.; Rajagopalan, A. E.; Pan, Y.; Li, Y.; Williams, D. L.; Pedersen, E. A.; Thakral, M.; Previero, A.; Close, K. C.; Christoforou, C. P.; Cai, D.; Turner, G. C.; Clowney, E. J.

10.1101/2023.01.25.525425 — neuroscience — Posted on 2023-01-26

722 Distinct nonlinear spectrotemporal integration in primary and secondary auditory cortices

Kline, A. M.; Aponte, D. A.; Kato, H. K.

10.1101/2023.01.25.525588 — neuroscience — Posted on 2023-01-26

723 Spatial and Temporal Origin of The Third SARS-Cov-2 Outbreak in Taiwan

Tai, J.-H.; Low, Y. K.; Wang, S. C.-L.; Lin, H.-F.; Wang, T.-Y.; Lin, Y.-Y.; Foster, C.; van Hal, S. J.; Lai, Y.-Y.; Yeh, S.-H.; Chang, S.-Y.; Chen, P.-J.; Chaw, S.-M.; Wang, H.-Y.

10.1101/2022.07.04.498645 — evolutionary biology — Posted on 2023-01-26

724 Experimental considerations for study of C. elegans lysosomal proteins

Clancy, J. C.; Vo, A. A.; Myles, K. M.; Levenson, M. T.; Ragle, J. M.; Ward, J. D.

10.1101/2022.06.30.498309 — molecular biology — Posted on 2023-01-26

725 The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in C. albicans

Shrivastava, M.; Kouyoumdjian, G. S.; Kirbizakis, E.; Ruiz-Garcia, D. A.; Henry, M.; Vincent, A. T.; Sellam, A.; Whiteway, M.

10.1101/2023.01.24.524502 — genetics — Posted on 2023-01-26

726 Structural variation across 138,134 samples in the TOPMed consortium

Jun, G.; English, A. C.; Metcalf, G. A.; Yang, J.; Chaisson, M. J.; Pankratz, N.; Menon, V. K.; Salerno, W. J.; Krasheninina, O.; Smith, A. V.; Lane, J. A.; Blackwell, T.; Kang, H. M.; Salvi, S.; Meng, Q.; Shen, H.; Pasham, D.; Bhamidipati, S.; Kottapalli, K.; Arnett, D. K.; Ashley-Koch, A.; Auer, P. L.; Beutel, K. M.; Bis, J. C.; Blangero, J.; Bowden, D. W.; Brody, J. A.; Cade, B. E.; Chen, Y.-D. I.; Cho, M. H.; Curran, J. E.; Fornage, M.; Freedman, B. I.; Fingerlin, T.; Gelb, B. D.; Hou, L.; Hung, Y.-J.; Kane, J. P.; Kaplan, R.; Kim, W.; Loos, R. J. F.; Marcus,, G. M.; Mathias, R. A.; McGarv

10.1101/2023.01.25.525428 — genomics — Posted on 2023-01-26

727 A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice

Setogawa, S.; Kanda, R.; Tada, S.; Hikima, T.; Saitoh, Y.; Ishikawa, M.; Nakada, S.; Seki, F.; Hikishima, K.; Matsumoto, H.; Mizuseki, K.; Fukayama, O.; Osanai, M.; Sekiguchi, H.; Ohkawa, N.

10.1101/2022.10.01.510247 — neuroscience — Posted on 2023-01-26

728 Feeding Neurons Integrate Metabolic and Reproductive States in Mice

Massa, M. G.; Scott, R. L.; Cara, A. L.; Cortes, L. R.; Sandoval, N. P.; Park, J. W.; Ali, S.; Velez, L.; Tesfaye, B.; Reue, K.; van Veen, J. E.; Seldin, M. M.; Correa, S. M.

10.1101/2023.01.25.525595 — neuroscience — Posted on 2023-01-26

729 The RALF Signaling Pathway Regulates Cell Wall Integrity during Pollen Tube Growth in Maize

Zhou, L.-Z.; Wang, L.; Ge, Z.; Mergner, J.; Li, X.; Kuster, B.; Längst, G.; Qu, L.-J.; Dresselhaus, T.

10.1101/2023.01.24.525389 — developmental biology — Posted on 2023-01-26

730 VRPG: an interactive web viewer for reference pangenome graph

Miao, Z.; Yue, J.-X.

10.1101/2023.01.20.524991 — bioinformatics — Posted on 2023-01-26

731 Four decades of phenology in an alpine amphibian: trends, stasis, and climatic drivers

Lenzi, O.; Grossenbacher, K.; Zumbach, S.; Luescher, B.; Althaus, S.; Schmocker, D.; Recher, H.; Thoma, M.; Ozgul, A.; Schmidt, B. R.

10.1101/2022.08.16.503739 — ecology — Posted on 2023-01-26

732 Selective recruitment: Evidence for task-dependent gating of inputs to the cerebellum

Shahshahani, L.; King, M.; Nettekoven, C.; Ivry, R.; Diedrichsen, J.

10.1101/2023.01.25.525395 — neuroscience — Posted on 2023-01-26

733 Individual Differences in Delay Discounting are Associated with Dorsal Prefrontal Cortex Connectivity in Youth

Mehta, K.; Pines, A.; Adebimpe, A.; Larsen, B.; Bassett, D. S.; Calkins, M. E.; Baller, E.; Gell, M.; Patrick, L. M.; Gur, R. E.; Gur, R. C.; Roalf, D. R.; Romer, D.; Wolf, D. H.; Kable, J. W.; Satterthwaite, T. D.

10.1101/2023.01.25.525577 — neuroscience — Posted on 2023-01-26

734 Hydrogels with stiffness-degradation spatial patterns control anisotropic 3D cell response

Garrido, C. A.; Garske, D. S.; Thiele, M.; Amini, S.; Real, S.; Duda, G. N.; Schmidt-Bleek, K.; Cipitria, A.

10.1101/2023.01.25.525504 — bioengineering — Posted on 2023-01-26

735 Intergenerational scaling law determines the precision kinematics of stochastic individual-cell-size homeostasis

Joshi, K.; Biswas, R. R.; Iyer-Biswas, S.

10.1101/2023.01.20.525000 — biophysics — Posted on 2023-01-25

736 Identification of a specific biomarker of Acinetobacter baumannii Global Clone 1 by machine learning and PCR related to metabolic fitness of ESKAPE pathogens.

Alvarez, V. E.; Quiroga, M. P.; Centron, D.

10.1101/2021.10.18.464923 — bioinformatics — Posted on 2023-01-25

737 Identification of CDRH3 Loops in the Naive B Cell Receptor Repertoire that Can Be Engaged by Candidate Immunogens

Swanson, O.; Beem, J. M.; Rhodes, B.; Wang, A.; Barr, M.; Chen, H.; Parks, R.; Saunders, K. O.; Haynes, B. F.; Wiehe, K.; Azoitei, M. L.

10.1101/2021.12.18.473225 — immunology — Posted on 2023-01-25

738 The effects of biological sex on estimates of persistent inward currents in the human lower limb

Jenz, S. T.; Beauchamp, J. A.; Gomes, M. M.; Negro, F.; Heckman, C.; Pearcey, G.

10.1101/2022.10.09.511486 — neuroscience — Posted on 2023-01-25

739 Slow-rising and fast-falling dopaminergic dynamics jointly adjust negative prediction error in the ventral striatum

Shikano, Y.; Yagishita, S.; Tanaka, K. F.; Takata, N.

10.1101/2021.07.23.453499 — neuroscience — Posted on 2023-01-25

740 Decoupling of mRNA and protein expression in aging brains reveals the age-dependent adaptation of specific gene subsets

Khatir, I.; Brunet, M. A.; Meller, A.; Amiot, F.; Patel, T.; Lapointe, X.; Lopez, J. A.; Guilloy, N.; Castonguay, A.; Husain, M. A.; St Germain, J.; Boisvert, F. M.; Plourde, M.; Roucou, X.; Laurent, B.

10.1101/2022.10.02.509373 — biochemistry — Posted on 2023-01-25

741 Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

Shin, H.; Leung, A.; Costello, K. R.; Senapati, P.; Kato, H.; Lee, M.; Lin, D.; Tang, X.; Chen, Z. B.; Schones, D. E.

10.1101/2022.05.11.491514 — molecular biology — Posted on 2023-01-25

742 scPerturb: Harmonized Single-Cell Perturbation Data

Peidli, S.; Green, T. D.; Shen, C.; Gross, T.; Min, J.; Garda, S.; Yuan, B.; Schumacher, L. J.; Taylor-King, J.; Marks, D.; Luna, A.; Bluthgen, N.; Sander, C.

10.1101/2022.08.20.504663 — systems biology — Posted on 2023-01-25

743 Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation

Sporre, E.; Karlsen, J.; Schriever, K.; Asplund-Samuelsson, J.; Janasch, M.; Strandberg, L.; Kotol, D.; Zeckey, L.; Piazza, I.; Syren, P.-O.; Edfors, F.; Hudson, E. P.

10.1101/2022.03.15.483797 — systems biology — Posted on 2023-01-25

744 Hsf1 and the molecular chaperone Hsp90 support a "rewiring stress response" leading to an adaptive cell size increase in chronic stress

Maiti, S.; Bhattacharya, K.; Wider, D.; Hany, D.; Panasenko, O.; Bernasconi, L.; Hulo, N.; Picard, D.

10.1101/2023.01.25.525547 — cell biology — Posted on 2023-01-25

745 Bovine serum albumin promotes reactivation of viable but non-culturable Mycobacterium tuberculosis via activation of protein kinase-dependent cell division processes

Morishige, Y.; Murase, Y.; Chikamatsu, K.; Yamada, H.; Aono, A.; Igarashi, Y.; Kamada, K.; Shimomura, Y.; Hosoya, M.; Takaki, A.; Mitarai, S.

10.1101/2021.11.22.468319 — microbiology — Posted on 2023-01-25

746 Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells

Parween, F.; Singh, S. P.; Zhang, H. H.; Kathuria, N.; Otaizo-Carrasquero, F. A.; Shamsaddini, A.; Gardina, P. J.; Ganesan, S.; Kabat, J.; Lorenzi, H. A.; Myers, T. G.; Farber, J. M.

10.1101/2023.01.25.525561 — immunology — Posted on 2023-01-25

747 Distinct mechanisms underlie value-driven modulation of visual cortex by previously rewarded visual and auditory stimuli

Antono, J. E.; Dang, S.; Auksztulewicz, R.; Pooresmaeili, A.

10.1101/2023.01.25.525484 — neuroscience — Posted on 2023-01-25

748 Every individual makes a difference: A trinity derived from linking individual brain morphometry, connectivity and mentalising ability

Li, Z.; Dong, Q.; Hu, B.; Wu, H.

10.1101/2022.04.11.487870 — neuroscience — Posted on 2023-01-25

749 Engineering synthetic CopT/A-based genetic circuits for miRNA imaging and functional gene regulation

Zhang, C.; Shi, X.; Tang, C.; Du, Y.; Shu, W.; Wang, F.

10.1101/2023.01.25.525516 — synthetic biology — Posted on 2023-01-25

750 Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid

Mavropoulos, A.; Johnson, C.; Lu, V.; Nieto, J.; Schneider, E.; Saini, K.; Phelan, M. L.; Hsie, L.; Wang, M.; Cruz, J.; Mei, J.; Kim, J.; Lian, Z.; Li, N.; Boutet, S. C.; Wong-Thai, A.; Yu, W.; Lu, Q.-Y.; Kim, T.; Geng, Y.; Masaeli, M.; Lee, T. D.; Rao, J.

10.1101/2023.01.24.525423 — pathology — Posted on 2023-01-25

751 Characterizing the Interactions of Cell Membrane-Disrupting Peptides with Lipid-Functionalized Single-Walled Carbon Nanotube Systems for Antimicrobial Screening

Yadav, A.; Kelich, P.; Kallmyer, N. E.; Reuel, N. F.; Vukovic, L.

10.1101/2023.01.25.525557 — bioengineering — Posted on 2023-01-25

752 Ndel1 modulates dynein activation in two distinct ways

Garrott, S. R.; Gillies, J. P.; Siva, A.; Little, S. R.; El Jbeily, R.; DeSantis, M. E.

10.1101/2023.01.25.525437 — biochemistry — Posted on 2023-01-25

753 Conformationally responsive dyes enable protein-adaptive Differential Scanning Fluorometry

Wu, T.; Yu, J. C.; Suresh, A.; Gale-Day, Z. J.; Alteen, M. G.; Woo, A. S.; Millbern, Z.; Johnson, O. T.; Carroll, E. C.; Partch, C. L.; Fourches, D.; Vilnueza, N. R.; Vocadlo, D. J.; Gestwicki, J. E.

10.1101/2023.01.23.525251 — biochemistry — Posted on 2023-01-25

754 In-situ metagenomics: A platform for rapid sequencing and analysis of metagenomes in less than one day

Tamames, J.; Jiminez, D.; Redondo, A.; Martinez, S.; De los Rios, A.

10.1101/2023.01.25.525498 — genomics — Posted on 2023-01-25

755 Cell composition inference and identification of layer-specific spatial transcriptional profiles with POLARIS

Chen, J.; Luo, T.; Jiang, M.; Liu, J.; Gupta, G. P.; Li, Y.

10.1101/2022.12.08.519631 — genetics — Posted on 2023-01-25

756 Evolutionary loss of the β1-adrenergic receptor in salmonids

Joyce, W.

10.1101/2023.01.25.525509 — evolutionary biology — Posted on 2023-01-25

757 Improving genome quality through artificial truncating purifying selection using heat shock: case of carps

Kuzmin, A. V.; Vinogradov, E.; Balashov, D.; Kozenkova, E.; Iliushchenko, D.; Mikhailova, A. G.; Patlay, N.; Zakharenko, E.; Kozenkov, I. I.; Ptashnik, I.; Timonina, V. N.; Tretiakov, E.; Galimov, Y.; Haag, C. R.; Efimenko, B.; Gunbin, K.; Mizgirev, I.; Popadin, K.

10.1101/2023.01.20.524958 — evolutionary biology — Posted on 2023-01-25

758 Single cell transcriptomics of human prenatal anterior foregut-derived organs identifies distinct developmental signatures directing commitment and specialization of the thymic epithelial stroma

Mohammed, A.; Slepicka, P. F.; Solomon, B.; Hubka, K. M.; Nguyen, H. D.; Chavez, M. G.; Yeh, C. Y.; Winn, V. D.; Gifford, C. A.; Khatri, P.; Gentles, A.; Weinacht, K. G.

10.1101/2022.10.02.510339 — developmental biology — Posted on 2023-01-25

759 Microbiome modulates immunotherapy response in cutaneous squamous cell carcinoma

Voigt, A. Y.; Walter, A.; Prieto, K.; Pulido, A. d. M.; Bittencourt, B. M. B.; Young, T.; Graham, J. P.; Tsai, K. Y.; Sundberg, J. P.; Oh, J.

10.1101/2023.01.25.525369 — microbiology — Posted on 2023-01-25

760 Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination

de la Fuente, A. G.; Dittmer, M.; Heesbeen, E.; de la Vega-Gallardo, N.; White, J. A.; Young, A.; Mayne, K.; Falconer, J.; McMurran, C. E.; Innayatulah, M.; Tiwari, V.; Penalva, R.; Ingram, R. J.; Dombrowski, Y.; Fitzgerald, D. C.

10.1101/2023.01.25.525562 — neuroscience — Posted on 2023-01-25

761 GABA-mediated inhibition in visual feedback neurons fine-tunes Drosophila male courtship

Mabuchi, Y.; Cui, X.; Xie, L.; Kim, H.; Jiang, T.; Yapici, N.

10.1101/2023.01.25.525544 — neuroscience — Posted on 2023-01-25

762 Occipital and parietal cortex participate in a cortical network for transsaccadic discrimination of object shape and orientation

Baltaretu, B. R.; Stevens, W. D.; Freud, E.; Crawford, J. D.

10.1101/2021.03.29.437597 — neuroscience — Posted on 2023-01-25

763 Regulation of the hypertonic stress response by the 3' mRNA cleavage and polyadenylation complex

Urso, S.; Sathaseevan, A.; Derry, W. B.; Lamitina, T.

10.1101/2023.01.23.525244 — physiology — Posted on 2023-01-25

764 Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

Taylor, M. S.; Connie, W.; Fridy, P. C.; Senussi, Y.; Cheng, W.-C.; Heaps, J.; Mori, K.; Cohen, L.; Molloy, K. R.; Chait, B. T.; Goggins, M.; Bhan, I.; Franses, J. W.; Yang, X.; Taplin, M.-E.; Wang, X.; Christiani, D. C.; Johnson, B. E.; Meyerson, M.; Uppaluri, R.; Egloff, A. M.; Denault, E. N.; Spring, L. M.; Wang, T.-L.; Shih, I.-M.; Jung, E.; Arora, K. S.; Zukerberg, L. R.; Yilmaz, O. H.; Chi, G.; Norden, B. L.; Song, Y.; Nieman, L.; Parikh, A. R.; Strickland, M.; Mustelin, T.; Eng, G.; Yilmaz, O. H.; Matulonis, U. A.; Skates, S. J.; Rueda, B. R.; Drapkin, R.; Klempner, S. J.; Deshpande, V.

10.1101/2023.01.25.525462 — cancer biology — Posted on 2023-01-25

765 scTOP: physics-inspired order parameters for cellular identification and visualization

Yampolskaya, M.; Herriges, M.; Ikonomou, L.; Kotton, D.; Mehta, P.

10.1101/2023.01.25.525581 — biophysics — Posted on 2023-01-25

766 Zinc Alters the Supramolecular Organization of Nucleic Acid Complexes with Full-Length TIA1

Yang, Y.; Fritzsching, K.; He, S.; McDermott, A. E.

10.1101/2023.01.25.525508 — biophysics — Posted on 2023-01-25

767 The Evolution of Local Energetic Frustration in Protein Families

Freiberger, M. I.; Ruiz-Serra, V. I.; Pontes, C.; Romero-Durana, M.; Galaz-Davison, P.; Ramirez-Sarmiento, C.; Schuster, C. D.; Marti, M. A.; Wolynes, P. G.; Ferreiro, D. U.; Parra, R. G.; Valencia, A.

10.1101/2023.01.25.525527 — bioinformatics — Posted on 2023-01-25

768 Colorimetric Detector for Hydrogen Sulfide Detection in Industrial Environments Based on Silver Nanoparticles Synthesized in Streptomyces Bacteria

Souri, N.; Abbaszadeh, M.; Ghorbanzadeh, S.

10.1101/2023.01.25.525489 — bioengineering — Posted on 2023-01-25

769 PI(3,5)P2 Controls the Signaling Activity of Class I PI3K

Sun, J.; Song, S.; Singaram, I.; Sharma, A.; Wang, W.; Hu, Y.; Lo, W.-T.; Koch, P.; Zhao, J.; Haucke, V.; Gao, R.; Cho, W.

10.1101/2023.01.25.525550 — biochemistry — Posted on 2023-01-25

770 Rapid, DNA-induced subunit exchange by DNA gyrase

Germe, T.; Bush, N. G.; Baskerville, V.; Saman, D.; Benesch, J. L.; Maxwell, A.

10.1101/2022.09.08.507137 — biochemistry — Posted on 2023-01-25

771 Genome Skimming with Nanopore Sequencing Precisely Determines Global and Transposon DNA Methylation in Vertebrates

Faulk, C.

10.1101/2023.01.25.525540 — genomics — Posted on 2023-01-25

772 Rapid turnover and evolution of sex-determining regions among Sebastes rockfishes

Sykes, N. T. B.; Kolora, S. R. R.; Sudmant, P. H.; Owens, G. L.

10.1101/2023.01.19.524770 — evolutionary biology — Posted on 2023-01-25

773 Human scalp hair as a thermoregulatory adaptation

Lasisi, T.; Smallcombe, J. W.; Kenney, W. L.; Shriver, M. D.; Zydney, B.; Jablonski, N. G.; Havenith, G.

10.1101/2023.01.21.524663 — evolutionary biology — Posted on 2023-01-25

774 An efficient algorithm for Nash equilibria when harvesting interacting living resources

Del Santo O'Neill, T. J.; Rossberg, A. G.; Thorpe, R. P.

10.1101/2023.01.25.525330 — ecology — Posted on 2023-01-25

775 Structural asymmetry in biotic interactions as a tool to understand and forecast ecological persistence

Allen-Perkins, A.; Garcia-Callejas, D.; Bartomeus, I.; Godoy, O.

10.1101/2023.01.25.525558 — ecology — Posted on 2023-01-25

776 Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes generation of the whole lung

10.1101/2022.10.31.514628 — developmental biology — Posted on 2023-01-25

777 Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract

Spencer, B. L.; Job, A. M.; Robertson, C. M.; Hameed, Z. A.; Serchejian, C.; Wiafe-Kwakye, C. S.; Mendonca, J. C.; Apolonio, M. A.; Nagao, P. E.; Neely, M. N.; Korotkova, N.; Korotkov, K. V.; Patras, K. A.; Doran, K. S.

10.1101/2023.01.25.525443 — microbiology — Posted on 2023-01-25

778 Reticulocytes in donor RBC units enhance RBC alloimmunization

Thomas, T.; Qiu, A.; Kim, C. Y.; Gordy, D. E.; Miller, A.; Tredicine, M.; Dzieciatkowska, M.; Dei Zotti, F.; Hod, E. A.; D'Alessandro, A.; Zimring, J. C.; Spitalnik, S. L.; Hudson, K. E.

10.1101/2023.01.25.525560 — immunology — Posted on 2023-01-25

779 The memory of pathogenic IgE is contained within CD23+IgG1+ memory B cells poised to switch to IgE in food allergy

Ota, M.; Hoehn, K.; Ota, T.; Aranda, C.; Friedman, S.; Braga, W.; Malbari, A.; Kleinstein, S.; Sicherer, S.; Curotto de Lafaille, M.

10.1101/2023.01.25.525506 — immunology — Posted on 2023-01-25

780 Loss of genital epithelial barrier function is greater with depot-medroxyprogesterone acetate than intravaginal rings that release etonogestrel and ethinyl estradiol

Liu, M.; Miguel, R. D. V.; Calla, N. Q.; Aceves, K.; Fritts, L.; Miller, C. J.; Moss, J.; Baum, M. M.; Cherpes, T. L.

10.1101/2023.01.25.525538 — immunology — Posted on 2023-01-25

781 Need for CD8 T cell clusters to eliminate a malaria liver stage arises in part due to heterogeneity in killing efficacy of individual effector T cells

Bera, S.; Amino, R.; Cockburn, I. A.; Ganusov, V. V.

10.1101/2022.05.18.492520 — immunology — Posted on 2023-01-25

782 A Distinct Phenotype of Polarized Memory B cell holds IgE Memory

Koenig, J. F.; Knudsen, N. P. H.; Phelps, A.; Bruton, K.; Hoof, I.; Lund, G.; Libera, D. D.; Lund, A.; Christensen, L.; Glass, D. R.; Walker, T. D.; Fang, A.; Waserman, S.; Jordana, M.; Andersen, P. S.

10.1101/2023.01.25.525495 — immunology — Posted on 2023-01-25

783 Timing of behavioral responding to long-duration Pavlovian fear conditioned cues

Wright, K. M.; Kantor, C. E.; Moaddab, M.; McDannald, M. A.

10.1101/2023.01.25.525456 — neuroscience — Posted on 2023-01-25

784 Longitudinal study of functional brain networks for processing infant directed and adult directed speech during the first year

Haden, G. P.; Toth, B.; Istvan, W.

10.1101/2023.01.25.525490 — neuroscience — Posted on 2023-01-25

785 Rescue of normal excitability in LGI1-deficient epileptic neurons

Extremet, J.; Ramirez-Franco, J.; Fronzaroli-Molinieres, L.; Boumedine-Guignon, N.; Ankri, N.; El Far, O.; Garrido, J. J.; Debanne, D.; Russier, M.

10.1101/2023.01.25.525523 — neuroscience — Posted on 2023-01-25

786 Aluminium alters excitability by inhibiting calcium, sodium and potassium currents in bovine chromaffin cells.

Baraibar, A. M.; de Pascual, R.; Jimenez, V.; Hernandez, N.; Aguirregabiria, I. E.; Hernandez-Guijo, J. M.

10.1101/2023.01.25.525351 — neuroscience — Posted on 2023-01-25

787 Spatiotemporal dynamics of self-generated imagery reveal a reverse cortical hierarchy from cue-induced imagery

Hu, Y.; Yu, Q.

10.1101/2023.01.25.525474 — neuroscience — Posted on 2023-01-25

788 Taking stock of the past: A psychometric evaluation of the Autobiographical Interview

Lockrow, A. W.; Setton, R.; Spreng, K. A.; Sheldon, S.; Turner, G. R.; Spreng, R. N.

10.1101/2021.12.22.473803 — neuroscience — Posted on 2023-01-25

789 Analysis of skull thickness, scalp-to-cortex distance and association with age and sex in cognitively normal elderly

Zhang, J.; Treyer, V.; Gietl, A.; Sun, J.; Zhang, C.; Hock, C.; Razansky, D.; Nitsch, R. M.; Ni, R.

10.1101/2023.01.19.524484 — neuroscience — Posted on 2023-01-25

790 Variability of visual field maps in human early extrastriate cortex challenges the canonical model of organization of V2 and V3

Ribeiro, F. L.; York, A.; Zavitz, E.; Bollmann, S.; Rosa, M. G. P.; Puckett, A. M.

10.1101/2022.10.16.511648 — neuroscience — Posted on 2023-01-25

791 The worldwide invasion history of a pest ambrosia beetle inferred using population genomics

Urvois, T.; Perrier, C.; Roques, A.; Saune, L.; Courtin, C.; Kajimura, H.; Hulcr, J.; Cognato, A. I.; Auger-Rozenberg, M.-A.; Kerdelhue, C.

10.1101/2023.01.25.525497 — zoology — Posted on 2023-01-25

792 Synthetic genetic circuits to uncover and enforce the OCT4 trajectories of successful reprogramming of human fibroblasts

Ilia, K.; Shakiba, N.; Bingham, T.; Jones, R. D.; Kaminski, M. M.; Aravera, E.; Bruno, S.; Palacios, S.; Weiss, R.; Collins, J. J.; Del Vecchio, D.; Schlaeger, T. M.

10.1101/2023.01.25.525529 — synthetic biology — Posted on 2023-01-25

793 Genomic targets of HOP2 are enriched for features found at recombination hotspots

Daradur, J.; Kesserwan, M.; Freese, N. H.; Loraine, A. E.; Riggs, D.

10.1101/2023.01.25.525520 — plant biology — Posted on 2023-01-25

794 The Medicago truncatula nodule-specific cysteine-rich peptides, NCR343 and NCR-new35 are required for the maintenance of rhizobia in nitrogen-fixing nodules.

Horvath, B.; Gungor, B.; Toth, M.; Domonkos, A.; Ayaydin, F.; Saifi, F.; Chen, Y.; Biro, J. B.; Bourge, M.; Szabo, Z.; Toth, Z.; Chen, R.; Kalo, P.

10.1101/2023.01.23.523609 — plant biology — Posted on 2023-01-25

795 Predicted and Experimental NMR Chemical Shifts at Variable Temperatures: The Effect of Protein Conformational Dynamics

Yi, X.; Zhang, L.; Friesner, R.; McDermott, A. E.

10.1101/2023.01.25.525502 — biophysics — Posted on 2023-01-25

796 Mechanism of HflX-mediated recycling of E. coli ribosome studied by time-resolved cryo-EM

Bhattacharjee, S.; Frank, J.; Feng, X.

10.1101/2023.01.25.525430 — biophysics — Posted on 2023-01-25

797 E2EDA: Protein domain assembly based on end-to-end deep learning

Zhu, H.; Xia, Y.; Zhang, G.

10.1101/2023.01.25.525481 — bioinformatics — Posted on 2023-01-25

798 Tissue-specific collagen hydroxylation at GEP/GDP triplets mediated by P4HA2

WILHELM, D.; WURTZ, A.; ABOUELFARAH, H.; SANCHEZ, G.; BUI, C.; VINCOURT, J.-B.

10.1101/2023.01.25.524868 — biochemistry — Posted on 2023-01-25

799 Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages

Zarrow, J. E.; Alli-Oluwafuyi, A.-M.; Youwakim, C. M.; Kim, K.; Jenkins, A. N.; Suero, I. C.; Jones, M. R.; Mashhadi, Z.; Mackie, K. P.; Waterson, A. G.; Doran, A. C.; Sulikowski, G. A.; Davies, S. S.

10.1101/2023.01.25.525554 — biochemistry — Posted on 2023-01-25

800 Investigating variant and expression of CVD genes associated phenotypes among high-risk Heart Failure patients

Ahmed, Z.; Zeeshan, S.; Persaud, N.; Liang, B. T.

10.1101/2023.01.24.525457 — genomics — Posted on 2023-01-25

801 Structural basis for triacylglyceride extraction frommycobacterial inner membrane by MFS transporter Rv1410

Remm, S.; De Vecchis, D.; Schöppe, J.; Hutter, C. A. J.; Gonda, I.; Hohl, M.; Newstead, S.; Schäfer, L. V.; Seeger, M. A.

10.1101/2023.01.25.525346 — molecular biology — Posted on 2023-01-25

802 SRC-mediated and TKS5-enabled podosome formation is an inherent property of IPF fibroblasts, promoting ECM invasion and pulmonary fibrosis

Barbayianni, I.; Kanellopoulou, P.; Fanidis, D.; Ntouskou, E.-D.; Nastos, D.; Galaris, A.; Harokopos, V.; Hatzis, P.; Tsitoura, E.; Homer, R.; Kaminski, N.; Antoniou, K.; Crestani, B.; Tzouvelekis, A.; Aidinis, V.

10.1101/2023.01.25.522705 — molecular biology — Posted on 2023-01-25

803 The characterisation of phytoene synthase-1 and 2, and 1-D-deoxy-xylulose 5-phosphate synthase genes from red chilli pepper (Capsicum annuum)

Berry, H. M.; Zhou, N.; Rickett, D. V.; Baxter, C. J.; Enfissi, E. M. A.; Fraser, P. D.

10.1101/2023.01.25.525515 — molecular biology — Posted on 2023-01-25

804 Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage.

Warming, H.; Deinhardt, K.; Garland, P.; More, J.; Bulters, D.; Galea, I.; Vargas-Caballero, M.

10.1101/2023.01.25.525148 — neuroscience — Posted on 2023-01-25

805 Investigating the roles of reflexes and central pattern generators in the control and modulation of human locomotion using a physiologically plausible neuromechanical model

Di Russo, A.; Stanev, D.; Sabnis, A.; Danner, S. M.; Ausborn, J.; Armand, S.; Ijspeert, A.

10.1101/2023.01.25.525432 — neuroscience — Posted on 2023-01-25

806 Multi-region brain transcriptomes uncover two subtypes of aging individuals with differences in Alzheimer risk and the impact of APOEe4

Lee, A. J.; Ma, Y.; Yu, L.; Dawe, R. J.; McCabe, C.; Arfanakis, K.; Mayeux, R.; Bennett, D. A.; Klein, H.-U.; De Jager, P.

10.1101/2023.01.25.524961 — neuroscience — Posted on 2023-01-25

807 Electrophysiological signatures of visual recognition memory across all layers of mouse V1

Hayden, D. J.; Finnie, P. S. B.; Thomazeau, A.; Li, A. Y.; Cooke, S. F.; Bear, M. F.

10.1101/2023.01.25.524429 — neuroscience — Posted on 2023-01-25

808 Reinforcement Learning Is Impaired in the Sub-acute Post-stroke Period

Branscheidt, M.; Hadjiosif, A. M.; Anaya, M. A.; Keller, J.; Widmer, M.; Runnalls, K. D.; Luft, A. R.; Bastian, A. J.; Krakauer, J. W. M.; Celnik, P.

10.1101/2023.01.25.525408 — neuroscience — Posted on 2023-01-25

809 The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons

Zhang, C.; Yi, X.; Hou, M.; Li, Q.; Li, X.; Lu, L.; Qi, E.; Wu, M.; Qi, L.; Huan, J.; Qi, Z.; Lv, Y.; Kong, X.; Bi, M.; Feng, S.; Zhou, H.

10.1101/2023.01.25.525483 — neuroscience — Posted on 2023-01-25

810 Emphasis on quality in iNaturalist plant collections enhances learning and research utility

McNair, M. C.; Sexton, C. M.; Zenoble, M.

10.1101/2023.01.24.525445 — scientific communication and education — Posted on 2023-01-25

811 hb or not hb - when and why accounting for background mortality in toxicological survival models matters?

Plantade, J.; Baudrot, V.; Charles, S.

10.1101/2023.01.25.525496 — pharmacology and toxicology — Posted on 2023-01-25

812 Impact of structural sampling, coupling scheme and state of interest on the energy transfer in CP29

Petry, S.; Tremblay, J. C.; Götze, J. P.

10.1101/2023.01.25.525376 — biophysics — Posted on 2023-01-25

813 SARS-CoV-2 Omicron XBB.1.5 may be a cautionary variant by in silico study

Sugano, A.; Kataguchi, H.; Ohta, M.; Someya, Y.; Kimura, S.; Maniwa, Y.; Tabata, T.; Takaoka, Y.

10.1101/2023.01.18.524660 — bioinformatics — Posted on 2023-01-25

814 Unlocking the Power of R: A High-Accuracy Method for Measuring DAB Staining on Immunohistochemical Slides

Fares, M. A.; Tarek, K.; Djallal Eddine, R.

10.1101/2023.01.25.525505 — bioinformatics — Posted on 2023-01-25

815 Quiescence-inducing 3D-engineered matrix uncovers mechanosensitive and drug protective FHL2-p21 signaling axis

Bakhshandeh, S.; Taieb, H. M.; Varadarajan, A. R.; Lissek, S. M.; Huecker, S. M.; Lu, X.; Garske, D. S.; Young, S. A. E.; Contzen, J.; Gossen, M.; Kirsch, S.; Warfsmann, J.; Honarnejad, K.; Klein, C. A.; Cipitria, A.

10.1101/2023.01.25.525382 — bioengineering — Posted on 2023-01-25

816 Adaptive trends of sequence compositional complexity over pandemic time in the SARS-CoV-2 coronavirus

Oliver, J. L.; Bernaola-Galvan, P.; Perfectti, F.; Gomez-Martin, C.; Castiglione, S.; Raia, P.; Verdu, M.; Moya, A.

10.1101/2021.11.06.467547 — genomics — Posted on 2023-01-25

817 Cellular remodeling and JAK inhibition promote zygotic gene expression in the Ciona germline

Ohta, N.; Christiaen, L.

10.1101/2021.07.12.452040 — developmental biology — Posted on 2023-01-25

818 Combining modelling and experimental approaches to assess the feasibility of developing rice-oil palm agroforestry system

Perez, R. P. A.; VEZY, R.; Bordon, R.; Laisne, T.; Roques, S.; Rebolledo, M.-C.; Rouan, L.; Fabre, D.; Gibert, O.; de Raissac, M.

10.1101/2022.12.19.521043 — plant biology — Posted on 2023-01-25

819 Pilot Analysis of Genetic Effects on Personality Test Scores with AI: ABO Blood Type in Japan

Kanazawa, M.

10.1101/2023.01.15.524099 — genetics — Posted on 2023-01-25

820 A role for Toll-like receptor 3 in lung vascular remodeling associated with SARS-CoV-2 infection

Farkas, D.; Bogamuwa, S.; Piper, B.; Newcomb, G.; Gunturu, P.; Bednash, J. S.; Londino, J. D.; Elhance, A.; Nho, R.; Rosas Mejia, O.; Yount, J. S.; Horowitz, J. C.; Goncharova, E. A.; Mallampalli, R. K.; Robinson, R. T.; Farkas, L.

10.1101/2023.01.25.524586 — molecular biology — Posted on 2023-01-25

821 Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

Mitsi, E.; Diniz, M. O.; Reine, J.; Collins, A. M.; Robinson, R.; Hyder-Wright, A.; Farrar, M.; Liatsikos, K.; Hamilton, J.; Onyema, O.; Urban, B. C.; Solorzano, C.; Lambe, T.; Draper, S. J.; Weiskopf, D.; Sette, A.; Maini, M. K.; Ferreira, D. M.

10.1101/2023.01.25.525485 — immunology — Posted on 2023-01-25

822 Occipital and parietal cortex participate in a cortical network for transsaccadic discrimination of object shape and orientation

Baltaretu, B. R.; Stevens, W. D.; Freud, E.; Crawford, J. D.

10.1101/2021.03.29.437597 — neuroscience — Posted on 2023-01-25

823 A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects

Tillotson, R.; Yan, K.; Ruston, J.; de Young, T.; Cordova, A.; Turcotte-Cardin, V.; Yee, Y.; Taylor, C.; Visuvanathan, S.; Babbs, C.; Ivakine, E. A.; Sled, J. G.; Nieman, B. J.; Picketts, D. J.; Justice, M. J.

10.1101/2023.01.25.525394 — neuroscience — Posted on 2023-01-25

824 Adaptive coding of pain prediction error in the anterior insula

Hoskin, R.; Talmi, D.

10.1101/2021.10.15.464508 — neuroscience — Posted on 2023-01-25

825 Activity-dependent glassy cell mechanics : Mechanical properties measured with active microrheology

Ebata, H.; Umeda, K.; Nishizawa, K.; Ngao, W.; Inokuchi, S.; Sugino, Y.; Miyamoto, T.; Mizuno, D.

10.1101/2022.09.02.506288 — biophysics — Posted on 2023-01-25

826 DISCO: A deep learning ensemble for uncertainty-aware segmentation of acoustic signals

Colligan, T.; Irish, K.; Emlen, D. J.; Wheeler, T. J.

10.1101/2023.01.24.525459 — bioinformatics — Posted on 2023-01-25

827 RAMEN identifies effective indicators for severe COVID and Long COVID patients

Xiong, Y.; Wang, J.; Shang, X.; Chen, T.; Fonseca, G.; Rousseau, S.; Ding, J.

10.1101/2023.01.24.525413 — bioinformatics — Posted on 2023-01-25

828 The Ribosome Maturation Factor Rea1 utilizes nucleotide independent and ATP hydrolysis driven Linker remodelling for the removal of ribosome assembly factors

Busselez, J.; Koenig, G.; Klos, T.; Sosnowski, P.; Marechal, N.; Gizardin-Fredon, H.; Cianferani, S.; Dominique, C.; Henry, Y.; Henras, A.; Schmidt, H.

10.1101/2022.11.03.515000 — biochemistry — Posted on 2023-01-25

829 Three-way relationships between gut microbiota, helminth assemblages and bacterial infections in wild rodent populations

Bouilloud, M.; Galan, M.; Dubois, A.; Diagne, C.; Marianneau, P.; Roche, B.; Charbonnel, N.

10.1101/2022.05.23.493084 — ecology — Posted on 2023-01-25

830 SIRT2 inhibition protects against cardiac hypertrophy and heart failure

Yang, X.; Chang, H.-C.; Tatekoshi, Y.; Balibegloo, M.; Wu, R.; Chen, C.; Sato, T.; Shapiro, J. S.; Ardehali, H.

10.1101/2023.01.25.525524 — molecular biology — Posted on 2023-01-25

831 Coronaviruses use ACE2 monomers as entry receptors

Eiring, P.; Klein, T.; Backes, S.; Streit, M.; Doose, S.; Beliu, G.; Sauer, M.

10.1101/2023.01.25.525479 — molecular biology — Posted on 2023-01-25

832 Stem cell factor and granulocyte colony-stimulating factor promote remyelination in the chronic phase of severe traumatic brain injury

Qiu, X.; Ping, S.; Kyle, M.; Chin, L.; Zhao, L.-R.

10.1101/2023.01.24.525450 — neuroscience — Posted on 2023-01-25

833 Network-based cytokine inference implicates Oncostatin M as a driver of knee osteoarthritis

Iijima, H.; Ambrosio, F.; Matsui, Y.

10.1101/2023.01.24.525463 — systems biology — Posted on 2023-01-25

834 Non-alcoholic steatohepatitis disrupts diurnal liver transcriptome rhythms in mice

de Assis, L. V.; Demir, M.; Oster, H.

10.1101/2023.01.24.525228 — physiology — Posted on 2023-01-25

835 Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid

10.1101/2023.01.24.525423 — pathology — Posted on 2023-01-25

836 in vivo quantitative FRET small animal imaging: intensity versus lifetime-based FRET

Smith, J. T.; Sinsuebphon, N.; Rudkouskaya, A.; Michalet, X.; Intes, X.; Barroso, M.

10.1101/2023.01.24.525411 — biophysics — Posted on 2023-01-25

837 The Multi-State Epigenetic Pacemaker enables the identification of combinations of factors that influence DNA methylation

Farrell, C.; Lapborisuth, K.; Snir, S.; Pellegrini, M.

10.1101/2023.01.24.525448 — bioinformatics — Posted on 2023-01-25

838 scTopoGAN: Unsupervised manifold alignment of single-cell data

Singh, A.; Reinders, M.; Mahfouz, A.; Abdelaal, T.

10.1101/2022.04.27.489829 — bioinformatics — Posted on 2023-01-25

839 Interleg coordination is not strictly controlled during walking

Arai, T.; Ota, K.; Funato, T.; Tsuchiya, K.; Aoyagi, T.; Aoi, S.

10.1101/2023.01.24.525466 — bioengineering — Posted on 2023-01-25

840 Volumetric Printing across Melt Electrowritten Scaffolds Fabricates Multi-Material Living Constructs with Tunable Architecture and Mechanics

Groessbacher, G.; Bartolf Kopp, M.; Gergely, C.; Nunez Bernal, P.; Florczak, S.; de Ruijter, M.; Groll, J.; Malda, J.; Jungst, T.; Levato, R.

10.1101/2023.01.24.525418 — bioengineering — Posted on 2023-01-25

841 The multilevel society of proboscis monkeys with a possible patrilineal basis

Matsuda, I.; Murai, T.; Grueter, C. C.; Tuuga, A.; Goossens, B.; Bernard, H.; Yahya, N. K.; Orozco-terWengel, P.; Salgado-Lynn, M.

10.1101/2023.01.24.525467 — animal behavior and cognition — Posted on 2023-01-25

842 Building a genome-based understanding of bacterial pH preferences

Ramoneda, J.; Stallard-Olivera, E.; Hoffert, M.; Winfrey, C. C.; Stadler, M.; Nino-Garcia, J. P.; Fierer, N.

10.1101/2023.01.24.524446 — ecology — Posted on 2023-01-25

843 Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

Colozza, G.; Lee, H.; Merenda, A.; Wu, S.-H.; Catala-Bordes, A.; Radaszkiewicz, T.; Jordens, I.; Lee, J.-H.; Bamford, A.-D.; Farnhammer, F.; Low, T. Y.; Maurice, M. M.; Bryja, V.; Kim, J.; Koo, B.-K.

10.1101/2023.01.24.525366 — cell biology — Posted on 2023-01-25

844 Systematic Analysis of Network-driven Adaptive Resistance to CDK4/6 and Estrogen Receptor Inhibition using Meta-Dynamic Network Modelling

Hart, A. J.; Shin, S.; Nguyen, L. K.

10.1101/2023.01.24.525460 — molecular biology — Posted on 2023-01-25

845 Cardiomyocyte apoptosis contributes to contractile dysfunction in stem cell model of MYH7 E848G hypertrophic cardiomyopa-thy

Loiben, A. M.; Chien, W.-M.; Friedman, C. E.; Chao, L. S.-L.; Weber, G.; Goldstein, A.; Sniadecki, N.; Murry, C. E.; Yang, K.-C.

10.1101/2023.01.24.525458 — molecular biology — Posted on 2023-01-25

846 Shift from a Simplified to Complex Gut Microbiota Reduces Adenoma Burden in a Preclinical Rat Model of Colon Cancer

Busi, S. B.; Davis, D.; Moskowitz, J.; Amos-Landgraf, J.

10.1101/2023.01.20.524931 — microbiology — Posted on 2023-01-25

847 Alteration of neural network and hippocampal slice activation through exosomes derived from 5XFAD nasal lavage fluid

Kim, S. S.; Hong, J. W.

10.1101/2023.01.24.525465 — neuroscience — Posted on 2023-01-25

848 Prioritization of semantic over visuo-perceptual aspects in multi-item working memory

Kerren, C.; Linde-Domingo, J.; Spitzer, B.

10.1101/2022.06.29.498168 — neuroscience — Posted on 2023-01-25

849 Epidermal SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy

O'Brien, J.; Niehaus, P.; Remark, J.; Salimian, M.; Kevas, Y.; Rubin, S.; Kristian, T.; Chandrasekeran, K.; Lu, C. P.-J.; Russell, J.; Ho, C.-Y.

10.1101/2023.01.24.523981 — neuroscience — Posted on 2023-01-25

850 The circadian clock is required for rhythmic lipid transport in the Drosophila hemolymph in interaction with diet, photic condition and feeding

Amatobi, K. M.; Ozbek-Unal, A. G.; Schabler, S.; Deppisch, P.; Helfrich-Forster, C.; Mueller, M. J.; Wegener, C.; Fekete, A.

10.1101/2023.01.24.525412 — systems biology — Posted on 2023-01-25

851 Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation

Niu, Y.; Heddes, M.; Altaha, B.; Birkner, M.; Kleigrewe, K.; Meng, C.; Haller, D.; Kiessling, S.

10.1101/2023.01.24.525433 — physiology — Posted on 2023-01-25

852 The effects of repeated intraperitoneal administration of the GABAB receptor agonist baclofen on body weight in rats maintained on a restricted feeding schedule.

Ebenezer, I. S.

10.1101/2023.01.24.525410 — pharmacology and toxicology — Posted on 2023-01-25

853 Evaluating the solubility of compounds intended for intramammary infusion based upon tests conducted across a range of milk products using cephapirin sodium and benzathine as model drugs

Martinez, M.; Zhao, F.; Longstaff, D. G.; Gabriel, J. J.; Coffey, M. J.

10.1101/2023.01.24.525429 — pharmacology and toxicology — Posted on 2023-01-25

854 Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypanosoma congolense

Peylhard, M.; Berthier, D.; Dayo, G.-K.; Chantal, I.; Sylla, S.; Nidelet, S.; Dubois, E.; Martin, G.; Sempere, G.; Flori, L.; Thevenon, S.

10.1101/2022.06.10.495622 — pathology — Posted on 2023-01-25

855 Single-cell transcriptomic landscape deciphers novel olfactory neuroblastoma subtypes and intratumoral heterogeneity

Yang, J.; Song, X.; Zhang, H.; Liu, Q.; Wei, R.; Guo, L.; Yuan, C.; Xue, K.; Lai, Y.; Wang, L.; Hu, L.; Wang, H.; Zhang, C.; Zhang, Q.; Gu, Y.; Zhao, W.; Yu, H.; Wang, J.; Liu, Z.; Li, H.; Zheng, S.; Liu, J.; Yang, L.; Li, W.; Xu, R.; Chen, J.; Zhou, Y.; Cheng, X.; Yu, Y.; Wang, D.; Sun, X.; Yu, H.

10.1101/2023.01.24.522680 — cancer biology — Posted on 2023-01-25

856 The Impact of Multiple Sequence Alignment Error on Phylogenetic Estimation under Variable-Across-Phylogeny Substitution Models

Doko, R.; Liu, K. J.

10.1101/2023.01.24.525451 — bioinformatics — Posted on 2023-01-25

857 Leveraging genomic redundancy to improve inference and alignment of orthologous proteins

Singleton, M.; Eisen, M.

10.1101/2023.01.24.525427 — bioinformatics — Posted on 2023-01-25

858 RAREFAN: A webservice to identify REPINs and RAYTs in bacterial genomes

Fortmann-Grote, C.; von Irmer, J.; Bertels, F.

10.1101/2022.05.22.493013 — bioinformatics — Posted on 2023-01-25

859 Investigating the Complexity of Gene Co-expression Estimation for Single-cell Data

Zhang, J.; Singh, R.

10.1101/2023.01.24.525447 — bioinformatics — Posted on 2023-01-25

860 A Comparison of Lossless Compression Methods in Microscopy Data Storage Applications

Walker, L. A.; Li, Y.; McGlothlin, M.; Cai, D.

10.1101/2023.01.24.525380 — bioinformatics — Posted on 2023-01-25

861 Lets Get Physical: On Observing Force Perturbations of Proliferating Glioblastoma-related Astrocyte Cells

Seto, J.; Chen, Y.

10.1101/2023.01.24.525397 — bioengineering — Posted on 2023-01-25

862 Lung-mimicking hydrogel culture system reproduces several tuberculosis phenotypes and demonstrates pyrazinamide efficacy

Kolluru, G. V. G.; S., A. P.; M., J. K.; Jeyasankar, S.; Raghunathan, V.; Agarwal, R.

10.1101/2023.01.24.525291 — bioengineering — Posted on 2023-01-25

863 Co-transplantation with mesenchymal stem cells and endothelial cells improvise islet engraftment and survival in STZ treated hyperglycemic mice

Naqvi, R. A.; Naqvi, A.

10.1101/2023.01.24.525444 — biochemistry — Posted on 2023-01-25

864 Importance of eDNA taphonomy and provenance for robust ecological inference: insights from interfacial geochemistry

Sand, K. K.; Jelavic, S.; Kjaer, K. H.; Prohaska, A.

10.1101/2023.01.24.525431 — biochemistry — Posted on 2023-01-25

865 Hatchling fish disperse using an efficient multisensory strategy

Lin, A.; Alvarez-Salvado, E.; Milicic, N.; Pujara, N.; Ehrlich, D. E.

10.1101/2023.01.24.525385 — animal behavior and cognition — Posted on 2023-01-25

866 A Comprehensive Atlas of Perineuronal Net Distribution and Colocalization with Parvalbumin in the Adult Mouse Brain

Lupori, L.; Totaro, V.; Cornuti, S.; Ciampi, L.; Carrara, F.; Grilli, E.; Viglione, A.; Tozzi, F.; Putignano, E.; Mazziotti, R.; Amato, G.; Gennaro, C.; Tognini, P.; Pizzorusso, T.

10.1101/2023.01.24.525313 — neuroscience — Posted on 2023-01-25

867 Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations

Brown, J.; Camporesi, E.; Lantero-Rodriguez, J.; Olsson, M.; Wang, A.; Medem, B.; Zetterberg, H.; Blennow, K.; Wall, M. J.; Karikari, T. K.; Hill, E.

10.1101/2023.01.24.525362 — neuroscience — Posted on 2023-01-25

868 Functional connectivity between the amygdala and prefrontal cortex underlies processing of emotion ambiguity

Sun, S.; Yu, H.; Yu, R.; Wang, S.

10.1101/2023.01.24.525116 — neuroscience — Posted on 2023-01-25

869 Path analysis reveals that corticosterone mediates gluconeogenesis from fat-derived substrates during acute stress in songbirds

Fokidis, B.

10.1101/2023.01.24.525409 — physiology — Posted on 2023-01-25

870 Molecular portraits of colorectal cancer morphological regions

Budinska, E.; Hrivnakova, M.; Catela Ivkovic, T.; Madrzyk, M.; Nenutil, R.; Bencsikova, B.; Al Tukmachi, D.; Ruckova, M.; Zdrazilova Dubska, L.; Slaby, O.; Feit, J.; Dragomir, M.-P.; Borilova Linhartova, P.; Tejpar, S.; Popovici, V.

10.1101/2023.01.24.525310 — cancer biology — Posted on 2023-01-25

871 A 3D adrenocortical carcinoma tumor platform for preclinical modeling of drug response and matrix metalloproteinase activity

Dedhia, P.; Sivakumar, H.; Rodriguez, M. A.; Nairon, K. G.; Zent, J. M.; Zheng, X.; Jones, K.; Popova, L.; Leight, J. L.; Skardal, A.

10.1101/2023.01.24.525287 — cancer biology — Posted on 2023-01-25

872 Transient Aurein 1.2 pores in prokaryotic model bilayers explored by coarse-grain molecular dynamics simulations: as glycolipid content increases, pore lifetime decreases.

Balatti, G. E.; Martini, F.; Pickholz, M. A.

10.1101/2023.01.24.525384 — biophysics — Posted on 2023-01-25

873 Cell Instance Segmentation via Multi-Scale Non-local Correlation

Duan, B.; CAO, J.; Wang, W.; Cai, D.; Yan, Y.

10.1101/2023.01.24.525387 — bioinformatics — Posted on 2023-01-25

874 Delineating genotypes and phenotypes of individual cells from long-read single cell transcriptomes

Shiau, C.-k.; Lu, L.; Kieser, R.; Fukumura, K.; Pan, T.; Lin, H.-Y.; Yang, J.; Tong, E. L.; Lee, G.; Yan, Y.; Huse, J.; Gao, R.

10.1101/2023.01.24.525264 — bioinformatics — Posted on 2023-01-25

875 The Impact of Species Tree Estimation Error on Cophylogenetic Reconstruction

Zheng, J.; Nishida, Y.; Okrasinska, A.; Bonito, G. M.; Heath-Heckman, E. A.; Liu, K. J.

10.1101/2023.01.24.525446 — bioinformatics — Posted on 2023-01-25

876 In vitro and in vivo Antioxidant potential of aqueous and hydroethanolic extracts leaves of Dracaena deisteliana Eng. (Dracacenaceae)

Feudjio, H. B. L.; Chekem Goka, M. S.; Josias, J. D.; Kamsu, G. T.; Sokoudjou, J. B.; Famen, L.-C. N.; Kodjio, N.; Gatsing, D.

10.1101/2023.01.24.525426 — biochemistry — Posted on 2023-01-25

877 Microsaccades are directed towards the midpoint between targets in a variably cued attention task

Willett, S. M.; Mayo, J. P.

10.1101/2023.01.24.525403 — animal behavior and cognition — Posted on 2023-01-25

878 A fundamental law underlying predictive remapping

Adeyefa-Olasupo, I.-E.

10.1101/2023.01.24.525276 — neuroscience — Posted on 2023-01-25

879 SynBa: Improved estimation of drug combination synergies with uncertainty quantification

Zhang, H.; Ek, C. H.; Rattray, M.; Milo, M.

10.1101/2023.01.24.524900 — pharmacology and toxicology — Posted on 2023-01-25

880 Contribution of protein conformational heterogeneity to NMR lineshapes at cryogenic temperatures

Yi, X.; Fritzsching, K.; Rogawski, R.; Xu, Y.; McDermott, A. E.

10.1101/2023.01.24.525358 — biophysics — Posted on 2023-01-25

881 Towards Analyzing the Reclassification Dynamics of ClinVar Variants

Ruscheinski, A.; Reimler, A. L.; Ewald, R.; Uhrmacher, A. M.

10.1101/2023.01.24.525342 — bioinformatics — Posted on 2023-01-25

882 {Theta}-Net: Achieving Enhanced Phase-Modulated Optical Nanoscopy in silico through a computational 'string of beads' architecture

Kaderuppan, S. S.; Wong, E. W. L.; Sharma, A.; Woo, W. L.

10.1101/2023.01.24.525271 — bioinformatics — Posted on 2023-01-25

883 A new web resource to predict the impact of missense variants at protein interfaces using 3D structural data: Missense3D-PPI

Pennica, C.; Hanna, G.; Islam, S.; Sternberg, M. J. E.; David, A.

10.1101/2023.01.24.525222 — bioinformatics — Posted on 2023-01-25

884 Deep Learning Assisted Smartphone-based Quantitative Microscopy for Label-free Hematological Analysis

Huang, B.; Kang, L.; Tsang, V. T. C.; Lo, C. T. K.; Wong, T. T. W.

10.1101/2023.01.24.525176 — bioengineering — Posted on 2023-01-25

885 From breast cancer cell homing to the onset of early bone metastasis: dynamic bone (re)modeling as a driver of osteolytic disease

Young, S. A. E.; Heller, A.-D.; Garske, D. S.; Rummler, M.; Qian, V.; Ellinghaus, A.; Duda, G. N.; Willie, B.; Grueneboom, A.; Cipitria, A.

10.1101/2023.01.24.525352 — bioengineering — Posted on 2023-01-25

886 Neo-natal castration leads to subtle differences in porcine anterior cruciate ligament morphology and function in adolescence

Thompson, J. D.; Howe, D.; Griffith, E. H.; Schnabel, L. V.; Fisher, M. B.

10.1101/2023.01.24.524954 — bioengineering — Posted on 2023-01-25

887 Metachronal coordination enables omnidirectional swimming via spatially distributed propulsion

Herrera-Amaya, A.; Byron, M.

10.1101/2023.01.23.525300 — animal behavior and cognition — Posted on 2023-01-25

888 Nature Forest Reserves in Tanzania and their importance for conservation

Ract, C. C.; Burgess, N.; Dinesen, L.; Sumbi, P.; Malugu, I.; Latham, J.; Anderson, L.; Gereau, R. E.; Goncalves de Lima, M.; Akida, A.; Nashanda, E.; Lyatuu, G.; Platts, P.; Rovero, F.

10.1101/2023.01.24.525332 — ecology — Posted on 2023-01-25

889 Sensitive clustering of protein sequences at tree-of-life scale using DIAMOND DeepClust

Buchfink, B.; Ashkenazy, H.; Reuter, K.; Kennedy, J. A.; Drost, H.-G.

10.1101/2023.01.24.525373 — genomics — Posted on 2023-01-25

890 Exploring the genetic diversity of the Japanese Population: Insights from a Large-Scale Whole Genome Sequencing Analysis

Kawai, Y.; Watanabe, Y.; Omae, Y.; Miyahara, R.; Khor, S.-S.; Noiri, E.; Kitajma, K.; Shimanuki, H.; Gatanaga, H.; Hata, K.; Hattori, K.; Iida, A.; Ishibashi-Ueda, H.; Kaname, T.; Kanto, T.; Matsumura, R.; Miyo, K.; Noguchi, M.; Ozaki, K.; Sugiyama, M.; Takahashi, A.; Tokuda, H.; Tomita, T.; Umezawa, A.; Watanabe, H.; Yoshida, S.; Goto, Y.-i.; Maruoka, Y.; Matsubara, Y.; Niida, S.; Mizokami, M.; Tokunaga, K.

10.1101/2023.01.23.525133 — genomics — Posted on 2023-01-25

891 ADAR1p150 Prevents MDA5 and PKR Activation via Distinct Mechanisms to Avert Fatal Autoinflammation

Hu, S.-B.; Heraud-Farlow, J.; Sun, T.; Liang, Z.; Goradia, A.; Taylor, S.; Walkley, C.; Li, J. B.

10.1101/2023.01.25.525475 — genetics — Posted on 2023-01-25

892 Detection for endogenous retroviral loci in Junglefowl using whole-genome sequencing

Ishihara, S.

10.1101/2023.01.24.525461 — genetics — Posted on 2023-01-25

893 Circadian rhythm disruption is associated with skeletal muscle dysfunction within the blind Mexican Cavefish

Olsen, L.; Krishnan, J.; Hassan, H.; Banks, C.; Rohner, N.

10.1101/2023.01.25.525368 — evolutionary biology — Posted on 2023-01-25

894 Global scale phylogeography of functional traits and microdiversity in Prochlorococcus

Ustick, L. J.; Larkin, A. A.; Martiny, A. C.

10.1101/2023.01.24.525399 — microbiology — Posted on 2023-01-25

895 Stereoinversion via alcohol dehydrogenases enables complete catabolism of β-1-type lignin-derived aromatic isomers

Kato, R.; Maekawa, K.; Kobayashi, S.; Hishiyama, S.; Katahira, R.; Nambo, M.; Higuchi, Y.; Kuatsjah, E.; Beckham, G. T.; Kamimura, N.; Masai, E.

10.1101/2023.01.24.525472 — microbiology — Posted on 2023-01-25

896 Group B Streptococcus drives major transcriptomic changes in the colonic epithelium.

Dominguez, K.; Lindon, A. K.; Gibbons, J.; Darch, S. E.; Randis, T. M.

10.1101/2023.01.24.525471 — microbiology — Posted on 2023-01-25

897 Yersinia Type III-Secreted Effectors Subvert Caspase-4-dependent Inflammasome Activation in Human Cells

Zhang, J.; Brodsky, I. E.; Shin, S.

10.1101/2023.01.24.525473 — microbiology — Posted on 2023-01-25

898 Gestational diabetes mellitus dysregulates the PD-1/PD-L1 axis at the feto-maternal interface

Mihalic, Z. N.; Kindler, O.; Raftopoulou, S.; Santiso, A.; Wadsack, C.; Heinemann, A.; Kargl, J.

10.1101/2023.01.25.525478 — immunology — Posted on 2023-01-25

899 Overexpression of NIMA-related kinase suppresses cell proliferation and tip growth in a liverwort Marchantia polymorpha

Mase, H.; Yoshitake, Y.; Kohchi, T.; Takahashi, T.; Motose, H.

10.1101/2023.01.25.525476 — plant biology — Posted on 2023-01-25

900 Diatom phytochromes integrate the entire visible light spectra for photosensing in marine environments

Duchene, C.; Bouly, J.-P.; Pierella Karlusich, J.; Selles, J.; Bailleul, B.; Bowler, C.; Ribera d'Alcala, M.; Falciatore, A.; Jaubert, M.

10.1101/2023.01.25.525482 — plant biology — Posted on 2023-01-25

901 Comprehensive comparative assessment of the Arabidopsis thaliana MLO2-calmodulin interaction by various in vitro and in vivo protein-protein interaction assays

von Bongartz, K.; Sabelleck, B.; Baquero Forero, A.; Kuhn, H.; Leissing, F.; Panstruga, R.

10.1101/2023.01.25.525488 — plant biology — Posted on 2023-01-25

902 Transpiration Responses to Potential Volatile Signals and Hydraulic Failure in Single Leaves of Vitis vinifera (cv. Shiraz) and Arabidopsis thaliana (Col 0) Utilising Sensitive Liquid Flow and Simultaneous Gas Exchange.

Balacey, S. L.; Capone, D. L.; Sullivan, W.; Tyerman, S.

10.1101/2023.01.24.525440 — plant biology — Posted on 2023-01-25

903 Spatially Resolved Transcriptomic Analysis of the Germinating Barley Grain

Whelan, J.; Lewsey, M. G.; Peirats Llobet, M.; Liew, L. C.; Yi, C.; Berkowitz, O.; Narsai, R.

10.1101/2023.01.24.525109 — plant biology — Posted on 2023-01-25

904 The transcriptional changes underlying the flowering phenology shift in response to climate warming

Komoto, H.; Hata, Y.; Kyozuka, J.; Kajita, Y.; Toyama, H.; Nagahama, A.; Satake, A.

10.1101/2023.01.24.524815 — plant biology — Posted on 2023-01-25

905 Distribution and genetic diversity of South Florida Tephrosia shed light on past cultural use

von Wettberg, E. J.; Sadle, J.; Ogutcen, E.; Possley, J.; Lange, J.; Carrasquila-Garcia, N.; Chang, P.

10.1101/2023.01.24.524594 — plant biology — Posted on 2023-01-25

906 Cell-free Chromatin Immunoprecipitation to detect molecular pathways in Physiological and Disease States

Jang, M. K.; Markowitz, T. E.; Andagie, T. E.; Apalara, Z.; Kuhn, S.; Agbor-Enoh, S.

10.1101/2023.01.24.525414 — genomics — Posted on 2023-01-25

907 Human milk variation is shaped by maternal genetics and impacts the infant gut microbiome

Johnson, K. E.; Heisel, T.; Allert, M.; Furst, A.; Yerabandi, N.; Knights, D.; Jacobs, K. M.; Lock, E. F.; Bode, L.; Fields, D. A.; Rudolph, M. C.; Gale, C. A.; Albert, F. W.; Demerath, E. W.; Blekhman, R.

10.1101/2023.01.24.525211 — genomics — Posted on 2023-01-25

908 Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase delta and Rad51-dependent mechanism

Al-Zain, A.; Nester, M. R.; Symington, L. S.

10.1101/2023.01.24.525421 — genetics — Posted on 2023-01-25

909 Experimental estimates of germline mutation rate in eukaryotes: a phylogenetic meta-analysis

Wang, Y.; Obbard, D. J.

10.1101/2023.01.24.525323 — evolutionary biology — Posted on 2023-01-25

910 Prenatal thyroid hormones accelerate postnatal growth and telomere shortening in wild great tits

Hsu, B.-Y.; Cossin-Sevrin, N.; Stier, A.; Ruuskanen, S.

10.1101/2021.12.22.473794 — evolutionary biology — Posted on 2023-01-25

911 Homeostatic activation of Aryl Hydrocarbon Receptor by dietary ligands dampens cutaneous allergic responses by controlling Langerhans cells migration

Cros, A.; de Juan, A.; Leclere, R.; Sampaio, J.; Maurin, M.; Heurtebise-Chretien, S.; Segura, E.

10.1101/2023.01.24.525336 — immunology — Posted on 2023-01-25

912 Cortical depth-dependent human fMRI of resting-state networks using EPIK

Pais-Roldan, P.; Yun, S. D.; Palomero-Gallagher, N.; Shah, J. N.

10.1101/2020.12.07.414144 — neuroscience — Posted on 2023-01-25

913 USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

Zheng, J.; Wu, S.; Tang, M.; Xi, S.; Wang, Y.; Ren, J.; Luo, H.; Hu, P.; Sun, L.; Du, Y.; Yang, H.; Wang, F.; Gao, H.; Dai, Z.; Ou, X.; Li, Y.

10.1101/2023.01.24.525324 — cancer biology — Posted on 2023-01-25

914 Increased Ca2+ signaling through CaV1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties

Li, H.; Korcari, A.; Ciufo, D.; Mendias, C. L.; Rodeo, S. A.; Buckley, M. R.; Loiselle, A. E.; Pitt, G. S.; Cao, C.

10.1101/2023.01.24.525119 — molecular biology — Posted on 2023-01-25

915 Shift from a Simplified to Complex Gut Microbiota Reduces Adenoma Burden in a Preclinical Rat Model of Colon Cancer

Busi, S. B.; Davis, D.; Moskowitz, J.; Amos-Landgraf, J.

10.1101/2023.01.20.524931 — microbiology — Posted on 2023-01-25

916 Structures of two main components of the virophage and Marseilleviridae virions extend the range of unrelated viruses using fiber head as common receptor binding fold

Jeudy, S.; Garcin, E.; Schmitt, A.; Abergel, C.

10.1101/2023.01.23.525297 — microbiology — Posted on 2023-01-25

917 The vestibular calyceal junction is dismantled in response to diverse injuring stimuli in rats and humans

Maroto, A. F.; Borrajo, M.; Prades, S.; Callejo, A.; Amilibia, E.; Perez-Grau, M.; Roca-Ribas, F.; Castellanos, E.; Barrallo-Gimeno, A.; Llorens, J.

10.1101/2022.05.17.492294 — neuroscience — Posted on 2023-01-25

918 The Effect of Anesthesia Gases on the Oxygen Reduction Reaction

Gupta, A.; Sang, Y.; Fontanesi, C.; Turin, L.; Naaman, R.

10.1101/2022.11.29.518334 — biophysics — Posted on 2023-01-25

919 Towards Analyzing the Reclassification Dynamics of ClinVar Variants

Ruscheinski, A.; Reimler, A. L.; Ewald, R.; Uhrmacher, A. M.

10.1101/2023.01.24.525342 — bioinformatics — Posted on 2023-01-25

920 Fractional Laser Treatment Boosts Systemic Anti-Tumor Immunity in Combination with OX40 Agonist and PD-1 Blockade

Kawakubo, M.; Glahn, J.; Tao, Z.; Demehri, S.; Manstein, D.

10.1101/2021.11.29.470433 — immunology — Posted on 2023-01-25

921 Clustering laminar cytoarchitecture: in vivo parcellation based on cortical granularity

Shamir, I.; Assaf, Y.; Shamir, R.

10.1101/2022.10.29.514347 — neuroscience — Posted on 2023-01-25

922 Brain age as an estimator of neurodevelopmental outcome: A deep learning approach for neonatal cot-side monitoring

Ansari, A.; Pillay, K.; Baxter, L.; Arasteh, E.; Dereymaeker, A.; Schmidt Mellado, G.; Jansen, K.; Naulaers, G.; Bhatt, A.; Van Huffel, S.; Hartley, C.; De Vos, M.; Slater, R.

10.1101/2023.01.24.525361 — neuroscience — Posted on 2023-01-25

923 Metabolically Primed Multipotent Hematopoietic Progenitors Fuel Innate Immunity

Cosgrove, J.; Lyne, A.-M.; Rodriguez, I.; Cabeli, V.; Tenreira-Bento, S.; Tubeuf, E.; Russo, E.; Tabarin, F.; Belloucif, Y.; Maleki-Toyserkani, S.; Reed, S.; Monaco, F.; Ager, A.; Lobry, C.; Bousso, P.; Fernandez-Marcos, P. J.; Isambert, H.; Arguello, R. J.; Perie, L.

10.1101/2023.01.24.525166 — immunology — Posted on 2023-01-24

924 TSD: Transformers for Seizure Detection

Ma, Y.; Liu, C.; Ma, M. S.; Yang, Y.; Truong, N. D.; Kothur, K.; Nikpour, A.; Kavehei, O.

10.1101/2023.01.24.525308 — bioengineering — Posted on 2023-01-25

925 Meisosomes, folded membrane platforms, link the epidermis to the cuticle in C. elegans

Aggad, D.; Brouilly, N.; Omi, S.; Essmann, C. L.; Dehapiot, B.; Savage-Dunn, C.; Richard, F.; Cazevieille, C.; Politi, K. A.; Hall, D. D.; Pujol, R.; Pujol, N.

10.1101/2021.11.26.470028 — cell biology — Posted on 2023-01-25

926 KDM6 demethylases mediate EWSR1-FLI1-driven oncogenic transformation in Ewing Sarcoma

Figuerola-Bou, E.; Rios-Astorch, C.; Blanco, E.; Sanchez-Jimenez, M.; Taboas, P.; Fernandez, G.; Gomez, S.; Munoz, O.; Castellano-Escuder, P.; Perez-Jaume, S.; Prada, E.; Mateo-Lozano, S.; Riggi, N.; Avgustinova, A.; Lavarino, C.; Di Croce, L.; Sanchez-Molina, S.; Mora, J.

10.1101/2023.01.24.524910 — cancer biology — Posted on 2023-01-24

927 A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

Wang, C.; Sun, M.; Shao, C.; Schlicker, L.; Zhuo, Y.; Harim, Y.; Peng, T.; Tian, W.; stoeffler, N.; Schneider, M.; Helm, D.; Mallm, J.-P.; Wu, Y.; Schulze, A.; LIU, H.-K.

10.1101/2023.01.24.525374 — cancer biology — Posted on 2023-01-24

928 Identification of diverse antibiotic resistant bacteria in agricultural soil with H218O stable isotope probing and metagenomics

Hernandez, M.; Roy, S.; Keevil, C. W.; Dumont, M. G.

10.1101/2023.01.24.525391 — microbiology — Posted on 2023-01-24

929 Fractions strategy differences in those born extremely preterm

Carr, S.; Babinchak, W. M.; Istrate, A.; Martyn-Dow, B.; Wang, G.; Chen, W.; Fondran, J.; Zhang, J.; Wein, M.; Yoon, S. Y.; Birnbaum, A.; Roth, E.; Gross, C.; Minich, N.; Thompson, L.; Kim, W. H.; Stern, Y.; Nosarti, C.; Taylor, H. G.; Tatsuoka, C.

10.1101/2022.12.06.519175 — neuroscience — Posted on 2023-01-24

930 In silico Antibody-Peptide Epitope prediction for Personalized cancer therapy

Jacobs, I.; Lim, C. M.; Emmanoil, M.; Malik, N.

10.1101/2023.01.23.525181 — cancer biology — Posted on 2023-01-24

931 Deterministic Early Endosomal MaturationsEmerge From a StochasticTrigger-and-Convert Mechanism

York, H. M.; Joshi, K.; Wright, C. S.; Kreplin, L. Z.; Rodgers, S.; Moorthi, U. K.; Gandhi, H.; Patil, A.; Mitchell, C.; Iyer-Biswas, S.; Arumugam, S.

10.1101/2022.04.15.488498 — biophysics — Posted on 2023-01-24

932 A Novel Hyper-Variable Variable Number Tandem Repeat in the Dopamine Transporter Gene (SLC6A3)

Apsley, A. T.; Domico, E. R.; Verbiest, M. A.; Brogan, C. A.; Buck, E. R.; Burich, A. J.; Cardone, K. M.; Stone, W. J.; Anisimova, M.; Vandenbergh, D. J.

10.1101/2022.08.03.502653 — genomics — Posted on 2023-01-24

933 Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse

Zhu, L.; Brown, A.; Pan, Q.; Fan, L.; Indersie, E.; Tian, C.; Timchenko, N.; Li, L.; Hansen, B. S.; Tan, H.; Lu, M.; Peng, J.; Pruett-Miller, S. M.; Yu, J.; Cairo, S.

10.1101/2023.01.24.525404 — cancer biology — Posted on 2023-01-24

934 Telomerase reactivation induces progression of mouse BrafV600E-driven thyroid cancers without telomere lengthening

Landa, I.; Thornton, C. E.; Xu, B.; Haase, J.; Krishnamoorthy, G.; Hao, J.; Knauf, J. A.; Herbert, Z. T.; Blasco, M. A.; Ghossein, R.; Fagin, J. A.

10.1101/2023.01.24.525280 — cancer biology — Posted on 2023-01-24

935 Disrupted in Renal Carcinoma 3 (DIRC3) impacts malignant phenotype and IGFBP5/IGF-1/Akt signaling axis in differentiated thyroid cancer.

Wysocki, P. T.; Czubak, K.; Marusiak, A. A.; Kolanowska, M.; Nowis, D.

10.1101/2023.01.24.525402 — cancer biology — Posted on 2023-01-24

936 Phenotyping of lymphoproliferative tumours generated in xenografts of non-small cell lung cancer

Pearce, D. R.; Akarca, A. U.; De Maeyer, R. P. H.; Kostina, E.; Huebner, A.; Sivakumar, M.; Karasaki, T.; Shah, K.; Janes, S. M.; McGranahan, N. E.; Reddy, V.; Akbar, A.; Moore, D. A.; Marafioti, T.; Swanton, C.; Hynds, R. E.

10.1101/2023.01.24.520089 — cancer biology — Posted on 2023-01-24

937 Spatiotemporal Dynamics of Vcam1 Regulates Cholangiocarcinoma Mass Expansion and Tumor Dissemination under Growth-suppressive Peritumoral Myofibroblasts

Zhu, L.; Tian, C.; Li, L.; Pan, Q.; Xu, B.; li, y.; Fan, L.; Brown, A.; Morrison, M.; Dey, K.; Yang, J. J.; Yu, J.; Glazer, E. S.

10.1101/2023.01.24.525379 — cancer biology — Posted on 2023-01-24

938 Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma

Kinnaman, M. D.; Zaccaria, S.; Makohon-Moore, A.; Arnold, B.; Levine, M.; Gundem, G.; Ossa, J. E. A.; Glodzik, D.; Sanchez, M. I. R.; Bouvier, N.; Li, S.; Stockfisch, E.; Dunigan, M.; Cobbs, C.; Bhanot, U.; You, D.; Mullen, K.; Melchor, J.; Ortiz, M. V.; O'Donohue, T.; Slotkin, E.; Wexler, L. H.; Cruz, F. S. D.; Hameed, M.; Bender, J. L. G.; Tap, W. D.; Meyers, P.; Papaemmanuil, E.; Kung, A. L.; Iacobuzio-Donahue, C. A.

10.1101/2023.01.05.522765 — cancer biology — Posted on 2023-01-24

939 Designed Ankyrin Repeat Proteins for detecting prostate-specific antigen expression in vivo

Gut, M.; Dreier, B.; Furler, S.; Sobek, J.; Plueckthun, A.; Holland, J. P.

10.1101/2023.01.24.525357 — biochemistry — Posted on 2023-01-24

940 A miniature cellulosome with novel interaction modes

Allan, J.; Black, G.

10.1101/2023.01.24.524588 — biochemistry — Posted on 2023-01-24

941 Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components

Kampmeyer, C.; Gronbaek-Thygesen, M.; Oelerich, N.; Tatham, M. H.; Cagiada, M.; Lindorff-Larsen, K.; Boomsma, W.; Hofmann, K.; Hartmann-Petersen, R.

10.1101/2022.12.08.519562 — biochemistry — Posted on 2023-01-24

942 Multimodal characterization of antigen-specific CD8+ T cells across SARS-CoV-2 vaccination and infection.

Zhang, B.; Upadhyay, R.; Hao, Y.; Samanovic, M. I.; Herati, R. S.; Blair, J.; Axelrad, J.; Mulligan, M. J.; Littman, D. R.; Satija, R.

10.1101/2023.01.24.525203 — genomics — Posted on 2023-01-24

943 A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva

Shatilovich, A.; Gade, V. R.; Pippel, M.; Hoffmeyer, T. T.; Tchesunov, A. V.; Stevens, L.; Winkler, S.; Hughes, G. M.; Traikov, S.; Hiller, M.; Rivkina, E.; Schiffer, P. H.; Myers, E. W.; Kurzchalia, T. V.

10.1101/2022.01.28.478251 — genomics — Posted on 2023-01-24

944 Allelic Transcription Factor binding shape transcriptional kinetics observed with scRNA-seq in human cell lines

Jin, B.; Feng, H.; Bush, W.

10.1101/2022.09.21.508743 — genetics — Posted on 2023-01-24

945 Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps

Maloisel, L. G.; Ma, E.; Phipps, J.; Deshayes, A.; Mattarocci, S.; Marcand, S.; Dubrana, K.; Coic, E.

10.1101/2021.05.27.446004 — genetics — Posted on 2023-01-24

946 Life history traits, pace-of-life and dispersal among and within five species of Trichogramma wasps: a comparative analysis

Guicharnaud, C.; Groussier, G.; Beranger, E.; Lamy, L.; Vercken, E.; Dahirel, M.

10.1101/2023.01.24.525360 — ecology — Posted on 2023-01-24

947 Temporal variability and cell mechanics control robustness in mammalian embryogenesis

Fabreges, D.; Corominas-Murtra, B.; Moghe, P.; Kickuth, A.; Ichikawa, T.; Iwatani, C.; Tsukiyama, T.; Daniel, N.; Gering, J.; Stokkermans, A.; Wolny, A.; Kreshuk, A.; Duranthon, V.; Uhlmann, V.; Hannezo, E.; Hiiragi, T.

10.1101/2023.01.24.525420 — developmental biology — Posted on 2023-01-24

948 Maternal and intrauterine influences on feto-placental growth are accompanied by sexually dimorphic changes in placental mitochondrial respiration, and metabolic signalling pathways

Salazar-Petres, E.; Pereira-Carvalho, D.; Lopez-Tello, J.; Sferruzzi-Perri, A. N.

10.1101/2023.01.24.525377 — developmental biology — Posted on 2023-01-24

949 A conserved, non-canonical insert in mitochondrial fission protein 1 (FIS1) is required for DRP1 and TBC1D15 recruitment and fission

Ihenacho, U. K.; Toro, R.; Mansour, R. H.; Hill, R. B.

10.1101/2023.01.24.525364 — cell biology — Posted on 2023-01-24

950 Y-complex nucleoporins independently contribute to nuclear pore assembly and gene regulation in neuronal progenitors

Orniacki, C.; Verrico, A.; Pelletier, S.; Souquet, B.; Coulpier, F.; Jourdren, L.; Benetti, S.; Doye, V.

10.1101/2023.01.24.524209 — cell biology — Posted on 2023-01-24

951 Circadian oscillation in primary cilium length by clock genes regulate fibroblast cell migration

Nakazato, R.; Matsuda, Y.; Ikegami, K.

10.1101/2023.01.24.525311 — cell biology — Posted on 2023-01-24

952 The N-terminus of Stag1 is required to repress the 2C program by maintaining rRNA expression and nucleolar integrity

Pezic, D.; Weeks, S.; Varsally, W.; Dewari, P. S.; Branco, M.; HADJUR, S.

10.1101/2021.02.14.429938 — cell biology — Posted on 2023-01-24

953 ZMYM2 controls transposable element transcription through distinct co-regulatory complexes.

Owen, D.; Aguilar-Martinez, E.; Ji, Z.; Li, Y.; Sharrocks, A.

10.1101/2023.01.24.525372 — molecular biology — Posted on 2023-01-24

954 ciRS-7-miR7 regulate ischemia induced neuronal death via glutamatergic signaling

Scoyni, F.; Sitnikova, V.; Giudice, L.; Korhonen, P.; Trevisan, D. M.; Hernandez de Sande, A.; Gomez-Budia, M.; Giniatullina, R.; Ugidos, I. F.; Dhungana, H.; Pistono, C.; Korvenlaita, N.; Valimaki, N.-N.; Kangas, S. M.; Hiltunen, A. E.; Kaikkonen-Maatta, M. U.; Koistinaho, J.; Yla-Herttuala, S.; Hinttala, R.; Veno, M. T.; Su, J.; Stoffel, M.; Schaefer, A.; Rajewsky, N.; Kjems, J.; La Pierre, M. P.; Piwecka, M.; Jolkkonen, J.; Giniatullin, R.; Hansen, T. B.; Malm, T.

10.1101/2023.01.24.525136 — molecular biology — Posted on 2023-01-24

955 A time- and space-resolved nuclear receptor atlas in mouse liver

Zummo, F. P.; Berthier, A.; Gheeraert, C.; Vinod, M.; Bobowski, M.; Molendi-Coste, O.; Pineau, L.; Jung, M.; Guille, L.; Chevalier-Dubois, J.; Dombrowicz, D.; Staels, B.; Eeckhoute, J.; Lefebvre, P.

10.1101/2023.01.24.525180 — molecular biology — Posted on 2023-01-24

956 Membrane-dependent actin polymerization mediated by the Legionella pneumophila effector protein MavH

Zhang, Q.; Wan, M.; Mao, Y.

10.1101/2023.01.24.525393 — molecular biology — Posted on 2023-01-24

957 Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs

Leroy, E. C.; Perry, T. N.; Renault, T. T.; Innis, C. A.

10.1101/2022.08.09.503329 — molecular biology — Posted on 2023-01-24

958 UL135 and UL136 Epistasis Controls Reactivation of Human Cytomegalovirus

Moy, M. A.; Collins-McMillen, D. K.; Crawford, L.; Parkins, C.; Zeltzer, S.; Caviness, K.; Caposio, P.; Goodrum, F.

10.1101/2023.01.24.525282 — microbiology — Posted on 2023-01-24

959 Temporally dynamic effects of adult diet on resistance and tolerance to bacterial infection in Aedes aegypti

Magistrado, D.; El-Dougdoug, N. K.; Short, S. M.

10.1101/2023.01.24.525229 — immunology — Posted on 2023-01-24

960 Transformation of primary murine peritoneal mast cells by constitutive KIT activation as a result of lost Cdkn2a/Arf expression

Capellmann, S.; Sonntag, R.; Schueler, H.; Meurer, S. K.; Gan, L.; Kauffmann, M.; Horn, K.; Koenigs-Werner, H.; Weiskirchen, R.; Liedtke, C.; Huber, M.

10.1101/2023.01.24.525344 — immunology — Posted on 2023-01-24

961 Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response

Bao, L.; fu, l.; su, y.; chen, z.; peng, z.; Sun, L.; Gonzalez, F. J.; wu, c.; zhang, h.; shi, b.; shi, y.-b.

10.1101/2023.01.24.524966 — immunology — Posted on 2023-01-24

962 Mast cell-derived BH4 is a critical mediator of postoperative pain

Starkl, P.; Jonsson, G.; Artner, T. J.; Turnes, B. L.; Serhan, N.; Oliveira, T.; Gail, L.-M.; Stejskal, K.; Channon, K.; Kocher, T.; Stary, G.; Klang, V.; Gaudenzio, N.; Knapp, S.; Woolf, C. J.; Penninger, J. M.; Cronin, S. J. F.

10.1101/2023.01.24.525378 — immunology — Posted on 2023-01-24

963 Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities

Patterson, A. R.; Needle, G. A.; Sugiura, A.; Chi, C.; Steiner, K. K.; Fisher, E. L.; Robertson, G. L.; Bodnya, C.; Markle, J. G.; Gama, V.; Rathmell, J. C.

10.1101/2023.01.24.525419 — immunology — Posted on 2023-01-24

964 Increased TCR signaling in regulatory T cells is disengaged from TCR affinity

Jing, Y.; Kong, Y.; Allard, D.; Liu, B.; Kolawole, E.; Sprouse, M.; Evavold, B.; Bettini, M.; Bettini, M.

10.1101/2023.01.17.523999 — immunology — Posted on 2023-01-24

965 DOT1L deletion impairs the development of cortical Parvalbumin-expressing interneurons

Cheffer, A.; Garcia-Miralles, M.; Maier, E. C.; Akol, I.; Franz, H.; Srinivasan, V. S. V.; Vogel, T.

10.1101/2023.01.24.525363 — neuroscience — Posted on 2023-01-24

966 Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson's disease

Sastre, D.; Zafar, F.; Torres, C. A. M.; Piper, D.; Kirik, D.; Sanders, L. H.; Qi, S.; Schuele, B.

10.1101/2023.01.24.525105 — neuroscience — Posted on 2023-01-24

967 Theta- and gamma-band oscillatory uncoupling in the macaque hippocampus

Abbaspoor, S.; Hussin, A.; Hoffman, K. L.

10.1101/2021.12.30.474585 — neuroscience — Posted on 2023-01-24

968 Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area

Lei, H. C.; Parker, K. E.; Yuede, C. M.; McCall, J. G.; Imai, S.-i.

10.1101/2023.01.19.524624 — neuroscience — Posted on 2023-01-24

969 Real-time feedback reduces participant motion during task-based fMRI

Rogers, C. S.; Jones, M. S.; McConkey, S.; McLaughlin, D. J.; Peelle, J. E.

10.1101/2023.01.12.523791 — neuroscience — Posted on 2023-01-24

970 Identifying the engagement of a brain network during a targeted tDCS-fMRI experiment using a machine learning approach

Shinde, A.; Mohapatra, S.; Schlaug, G.

10.1101/2022.09.12.507591 — neuroscience — Posted on 2023-01-24

971 Thermoneutral housing does not accelerate metabolic dysfunction-associated fatty liver disease in male or female mice fed a Western diet

Nunes, J. R.; Smith, T. K.; Ghorbani, P.; O'Dwyer, C.; Trzaskalski, N. A.; Dergham, H.; Pember, C.; Kilgour, M. K.; Mulvihill, E. E.; Fullerton, M. D.

10.1101/2023.01.24.524609 — physiology — Posted on 2023-01-24

972 Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes and Shortens Sinus Node Recovery Time

Ruan, H.; Mandla, R.; Ravi, N.; Galang, G.; Soe, A. W.; Olgin, J. E.; Lang, D.; Vedantham, V.

10.1101/2023.01.24.525392 — physiology — Posted on 2023-01-24

973 Competitive interaction between ATP and GTP regulates mitochondrial ATP-sensitive potassium channels

Palacio, P. B.; Soares, G. C. d. F.; Lima, G. M. B.; Cunha, P. L. O.; Varela, A. L. N.; Facundo, H. T.

10.1101/2023.01.24.525224 — pharmacology and toxicology — Posted on 2023-01-24

974 The regulatory role of the CD2AP/TKS4 interaction in EMT and its potential as abiomarker for colon cancer

Kurilla, A.; Laszlo, L.; Takacs, T.; Tilajka, A.; Lukacs, L.; Novak, J.; Pancsa, R.; Buday, L.; Vas, V.

10.1101/2023.01.13.523903 — cancer biology — Posted on 2023-01-24

975 Mora: abundance aware metagenomic read re-assignment for disentangling similar strains

Zheng, A.; Shaw, J.; Yu, Y. W.

10.1101/2022.10.18.512733 — bioinformatics — Posted on 2023-01-24

976 Gene networks driven by genetic variation for plasma cortisol in hepatic and adipose tissues implicate corticosteroid binding globulin in modulating tissue glucocorticoid action and cardiovascular risk

Bankier, S.; Wang, L.; Crawford, A.; Morgan, R. A.; Ruusalepp, A.; Andrew, R.; Bjorkegren, J. L.; Walker, B. R.; Michoel, T.

10.1101/2023.01.20.524857 — genetics — Posted on 2023-01-24

977 Evolution of two gene networks underlying adaptation to drought stress in the wild tomato Solanum chilense

Wei, K.; Sharifova, S.; Sinha, N. R.; Nakayama, H.; Tellier, A.; Silva Arias, G. A.

10.1101/2023.01.18.524537 — evolutionary biology — Posted on 2023-01-24

978 Buffering role of HSP shapes the molecular evolution of mammalian and human genomes at short and long-term scales

Timonina, V. N.; Tretiakov, E.; Goncharov, A.; Gunbin, K.; Fellay, J.; Popadin, K.

10.1101/2022.11.11.516130 — evolutionary biology — Posted on 2023-01-24

979 Environment as a limiting factor of the historical global spread of mungbean

Ong, P.-W.; Lin, Y.-P.; Chen, H.-W.; Lo, C.-Y.; Burlyaeva, M.; Noble, T.; Nair, R. M.; Schafleitner, R.; Vishnyakova, M.; von Wettberg, E.; Samsonova, M. G.; Nuzhdin, S.; Ting, C.-T.; Lee, C.-R.

10.1101/2022.04.27.489711 — evolutionary biology — Posted on 2023-01-24

980 The role of trade-offs and feedbacks in shaping integrated plasticity, behavioral syndromes, and behavioral correlations

Dochtermann, N. A.

10.1101/2021.07.26.453877 — evolutionary biology — Posted on 2023-01-24

981 The effects of climate drivers are more predictable for development than for other plant population vital rates

Compagnoni, A.; Knight, T. M.; Childs, D.; Salguero-Gomez, R.

10.1101/2022.03.11.484031 — ecology — Posted on 2023-01-24

982 Cyanotoxins accumulate in Lake St. Clair fish yet their fillets are safe to eat

Shahmohamadloo, R. S.; Bhavsar, S. P.; Ortiz Almirall, X.; Marklevitz, S. A.; Rudman, S. M.; Sibley, P. K.

10.1101/2022.09.08.507173 — ecology — Posted on 2023-01-24

983 Cohesin-independent STAG proteins interact with RNA and localise to R-loops to promote complex loading.

Porter, H.; Li, Y.; Varsally, W.; Neguembor, M. V.; Beltran, M.; Pezic, D.; Martin, L.; Tavares Cornejo, M.; Bhamra, A.; Surinova, S.; Jenner, R. G.; Cosma, M. P.; HADJUR, S.

10.1101/2021.02.20.432055 — cell biology — Posted on 2023-01-24

984 Utilization of an Artery-on-a-chip to unravel novel regulators and therapeutic targets in vascular diseases

Paloschi, V.; Pauli, J.; Winski, G.; Wu, Z.; Li, Z.; Glukha, N.; Hummel, N.; Rogowitz, R.; Meucci, S.; Botti, L.; Busch, A.; Chernogubova, E.; Jin, H.; Sachs, N.; Eckstein, H.-H.; Dueck, A.; Boon, R. A.; Bausch, A. R.; Maegdefessel, L.

10.1101/2022.11.29.517312 — cell biology — Posted on 2023-01-24

985 An EpCAM/Trop2 mechanostat differentially regulates individual and collective migration of human carcinoma cells

Aslemarz, A.; Fagotto-Kaufmann, M.; Ruppel, A.; Balland, M.; Lasko, P.; Fagotto, F.

10.1101/2022.10.03.510449 — cell biology — Posted on 2023-01-24

986 The cortico-thalamic loop attunes competitive lateral interactions across retinotopic and orientation preference maps

Guarino, D. G.; Davison, A. P.; Fregnac, Y.; Antolik, J.

10.1101/2022.12.19.521069 — neuroscience — Posted on 2023-01-24

987 Evaluation of Long-Short Term Memory Networks for M/EEG Source Imaging with Simulated and Real EEG Data

Hecker, L.; Rupprecht, R.; Tebartz van Elst, L.; Kornmeier, J.

10.1101/2022.04.13.488148 — neuroscience — Posted on 2023-01-24

988 Empirical methods for the validation of Time-To-Event mathematical models taking into account uncertainty and variability: Application to EGFR+ Lung Adenocarcinoma.

Jacob, E.; Perrillat-Mercerot, A.; Palgen, J.-L.; L'Hostis, A.; Ceres, N.; Boissel, J.-P.; Bosley, J.; Monteiro, C.; Kahoul, R.

10.1101/2022.09.08.507079 — systems biology — Posted on 2023-01-24

989 Improving Interdisciplinary Teaching through a Complexity Lens

Neitzel, S. B.; Zhao, Y.; Diaz Eaton, C.

10.1101/2022.05.26.493642 — scientific communication and education — Posted on 2023-01-24

990 Three-dimensional morphological analysis revealed the cell patterning bases for the sexual dimorphism development in the liverwort Marchantia polymorpha

Cui, Y.; Hisanaga, T.; Kajiwara, T.; Yamaoka, S.; Kohchi, T.; Goh, T.; Nakajima, K.

10.1101/2023.01.24.525312 — plant biology — Posted on 2023-01-24

991 Protein reservoirs of seeds are composites of amyloid and amyloid-like structures facilitating sustained release during germination and seedling growth

Sinha, N.; Zahra, T.; Gahane, A.; Rout, B.; Bhattacharya, A.; Basu, S.; Chakrabarti, A.; Thakur, A.

10.1101/2021.09.08.459376 — plant biology — Posted on 2023-01-24

992 A physicochemical cause of betaine lipid evolutionary loss in seed plants?

Bolik, S.; Schlaich, A.; Mukhina, T.; Amato, A.; Bastien, O.; Schneck, E.; Deme, B.; Jouhet, J.

10.1101/2023.01.24.525350 — plant biology — Posted on 2023-01-24

993 TSD: Transformers for Seizure Detection

Ma, Y.; Liu, C.; Ma, M. S.; Yang, Y.; Truong, N. D.; Kavehei, O.

10.1101/2023.01.24.525308 — bioengineering — Posted on 2023-01-24

994 CAM5, WRKY53, and TGA5 regulate defense gene expression mediated by the volatile organic compound ethyl vinyl ketone

Gong, J.; Guo, Z.; Wang, Z.; Yao, L.; Zhao, C.; Lin, S.; Ma, S.; Shen, Y.

10.1101/2023.01.24.525215 — plant biology — Posted on 2023-01-24

995 Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment

Misetic, H.; Keddar, M. R.; Jeannon, J.-P.; Ciccarelli, F. D.

10.1101/2023.01.24.525325 — cancer biology — Posted on 2023-01-24

996 NGS-enriched activated sludge modelling of an industrial wastewater treatment plant

Prawira Negara, M. A.; Keesman, K. J.; Euverink, G.-J. W.; Jayawardhana, B.

10.1101/2023.01.23.523537 — bioinformatics — Posted on 2023-01-24

997 Accurate and fast graph-based pangenome annotation and clustering with ggCaller

Horsfield, S. T.; Croucher, N. J.; Lees, J. A.

10.1101/2023.01.24.524926 — bioinformatics — Posted on 2023-01-24

998 Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer PDXs

Perron, U.; Grassi, E.; Chatzipli, A.; Viviani, M.; Karakoc, E.; Trastulla, L.; Isella, C.; Zanella, E. R.; Klett, H.; Molineris, I.; Schueler, J.; Esteller, M.; Medico, E.; Conte, N.; McDermott, U.; Trusolino, L.; Bertotti, A.; Iorio, F.

10.1101/2023.01.24.525314 — bioinformatics — Posted on 2023-01-24

999 Two avian Plasmodium species trigger different transcriptional responses on their vector Culex pipiens

Garrigos, M.; Ylla, G.; Martinez-de la Puente, J.; Figuerola, J.; Ruiz-Lopez, M. J.

10.1101/2023.01.24.525339 — genomics — Posted on 2023-01-24

1000 Dominant gingers: discovery and inheritance of a new shell polymorphism in the great pond snail Lymnaea stagnalis

Ledder, M.; Nakadera, Y.; Staikou, A.; Koene, J. M.

10.1101/2023.01.24.525303 — genetics — Posted on 2023-01-24

1001 Recovery of protein synthesis to measure transcription-coupled DNA repair in living cells and tissues

van der Woude, M.; Davo-Martinez, C.; Thijssen, K. L.; Vermeulen, W.; Lans, H.

10.1101/2023.01.24.525327 — genetics — Posted on 2023-01-24

1002 Sedimentary DNA can influence evolution:Establishing mineral facilitated horizontal gene transfer as a route to bacterial fitness

Verma, T.; Hendiani, S.; Andersen, S. B.; Burmoelle, M.; Sand, K. K.

10.1101/2023.01.24.525235 — evolutionary biology — Posted on 2023-01-24

1003 Learning accelerates the evolution of slow aging but obstructs negligible senescence

Lenart, P.; Psalmon, S.; Towbin, B. D.

10.1101/2023.01.24.525295 — evolutionary biology — Posted on 2023-01-24

1004 New climatically specialized lineages of Batrachochytrium dendrobatidis and their sub-lethal effects on amphibians establish the Asiatic origins of the pathogen

Sun, D.; Ellepola, G.; Herath, J.; Liu, H.; Liu, Y.; Murray, K.; Meegaskumbura, M.

10.1101/2023.01.23.525302 — evolutionary biology — Posted on 2023-01-24

1005 Putative APOBEC3 deaminase editing in MPXV as evidence for sustained human transmission since at least 2016.

O'Toole, A. N.; Neher, R.; Ndodo, N.; Borges, V.; Gannon, B.; Gomes, J. P.; Groves, N.; King, D. J.; Maloney, D.; Lemey, P.; Lewandowski, K.; Loman, N.; Myers, R.; Suchard, M. A.; Worobey, M.; Chand, M.; Ihekweazu, C.; Uleato, D.; Adetifa, I.; Rambaut, A.

10.1101/2023.01.23.525187 — evolutionary biology — Posted on 2023-01-24

1006 Enhancing additive series relay intercropping of grass pea (Lathyrus sativus L.) with low land rice (Oryza sativa L.) in North-Western Ethiopia: A farmer's indigenous knowledge

Bitew, Y.; Assefa, E.

10.1101/2023.01.24.525334 — ecology — Posted on 2023-01-24

1007 Intraspecific competition for a nest and its implication for the fitness of relocating ant colonies

Halder, E.; Annagiri, S.

10.1101/2023.01.24.525355 — ecology — Posted on 2023-01-24

1008 IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance

Rundberg Nilsson, A. J.; Xian, H.; Shalapour, S.; Cammenga, J.; Karin, M.

10.1101/2023.01.24.525321 — cell biology — Posted on 2023-01-24

1009 Bacillus subtilis RadA/Sms-mediated nascent lagging-strand un-winding at stalled or reversed forks is a two-step process: RadA/Sms assists RecA nucleation, and RecA loads RadA/Sms

Torres, R.; Carrasco, B.; Alonso, J. C.

10.1101/2023.01.24.525305 — molecular biology — Posted on 2023-01-24

1010 Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed -1 ribosomal frameshifting

Wei, L.-H.; Sun, Y.; Guo, J. U.

10.1101/2023.01.23.525275 — molecular biology — Posted on 2023-01-24

1011 The effects of social experience on host gut microbiome in male zebrafish (Danio rerio)

Scott, E.; Brewer, M. S.; Peralta, A. L.; Issa, F. A.

10.1101/2023.01.23.525298 — microbiology — Posted on 2023-01-24

1012 Why do some fungi want to be sterile? The role of dysfunctional Pro1 in the rice blast fungus

Uchida, M.; Konishi, T.; Fujigasaki, A.; Kita, K.; Arie, T.; Teraoka, T.; Arazoe, T.; Kamakura, T.

10.1101/2023.01.23.525283 — microbiology — Posted on 2023-01-24

1013 A conserved family of immune effectors cleaves cellular ATP upon viral infection

Rousset, F.; Yirmiya, E.; Nesher, S.; Brandis, A.; Mehlman, T.; Itkin, M.; Malitsky, S.; Millman, A.; Melamed, S.; Sorek, R.

10.1101/2023.01.24.525353 — microbiology — Posted on 2023-01-24

1014 Microbe-derived indole tunes organ-function and links microbe metabolites to biological ageing

Xing, P. Y.; Jayaraman, A.; Zhang, G. W.; Martin, K. A.; Faylon, L. E.; Kjelleberg, S.; Rice, S. A.; Wang, Y.; Bello, A. T.; Holmes, E.; Nicholson, J.; Whiley, L.; Pettersson, S.

10.1101/2023.01.24.525337 — microbiology — Posted on 2023-01-24

1015 Prefrontal cortical protease TACE/ADAM17 is involved in neuroinflammation and stress-related eating alterations

Sharafeddin, F.; Ghaly, M.; Simon, T. B.; Ontiveros-Angel, P.; Figueroa, J. D.

10.1101/2023.01.23.525269 — neuroscience — Posted on 2023-01-24

1016 Age differences in spatial memory are mitigated during naturalistic navigation

Hill, P. F.; McAvan, A. S.; Garren, J. D.; Grilli, M. D.; Barnes, C. A.; Ekstrom, A. D.

10.1101/2023.01.23.525279 — neuroscience — Posted on 2023-01-24

1017 Cell-type-specific inhibitory circuitry from a connectomic census of mouse visual cortex

Schneider-Mizell, C. M.; Bodor, A.; Brittain, D.; Buchanan, J.; Bumbarger, D. J.; Elabbady, L.; Kapner, D.; Kinn, S.; Mahalingam, G.; Seshamani, S.; Suckow, S.; Takeno, M.; Torres, R.; Yin, W.; Dorkenwald, S.; Bae, J. A.; Castro, M. A.; Fahey, P. G.; Froudarakis, E.; Halageri, A.; Jia, Z.; Jordan, C.; Kemnitz, N.; Lee, K.; Li, K.; Lu, R.; Macrina, T.; Mitchell, E.; Mondal, S. S.; Mu, S.; Nehoran, B.; Papadopoulos, S.; Patel, S.; Pitkow, X.; Popovych, S.; Silversmith, W.; Sinz, F.; Turner, N. L.; Wong, W.; Wu, J.; Yu, S.-c.; MICrONs Consortium, ; Reimer, J.; Tolias, A.; Seung, H. S.; Reid, R.

10.1101/2023.01.23.525290 — neuroscience — Posted on 2023-01-24

1018 GABAergic signaling shapes multiple aspects of Drosophila courtship motor behavior

Amin, H.; Nolte, S. S.; Swain, B.; von Philipsborn, A. C.

10.1101/2023.01.24.525304 — neuroscience — Posted on 2023-01-24

1019 Healthy aging and cognitive impairment alter EEG functional connectivity in distinct frequency bands

Ray, S.; Kumar, W. S.

10.1101/2023.01.24.525301 — neuroscience — Posted on 2023-01-24

1020 Guide to the construction and use of an adaptive optics two-photon microscope with direct wavefront sensing

Kleninfeld, D.; Yao, P.; Liu, R.; Thunemann, M.; Boggini, T.

10.1101/2023.01.24.525307 — neuroscience — Posted on 2023-01-24

1021 Static and dynamic functional connectomes represent largely similar information

Matkovic, A.; Anticevic, A.; Murray, J. D.; Repovs, G.

10.1101/2023.01.24.525348 — neuroscience — Posted on 2023-01-24

1022 Ramped V1 transcranial ultrasonic stimulation modulates but does not evoke visual evoked potentials

Nandi, T.; Johnstone, A.; Martin, E.; Cooper, R.; Bestmann, S.; Bergmann, T. O.; Treeby, B.; Stagg, C. J.

10.1101/2023.01.24.525317 — neuroscience — Posted on 2023-01-24

1023 Gradual change of cortical representations with growing visual expertise for synthetic shapes.

Kakaei, E.; Braun, J.

10.1101/2023.01.24.525322 — neuroscience — Posted on 2023-01-24

1024 Quantitative comparison between aMRI and DENSE for the assessment of brain tissue motion

Adams, A. L.; Terem, I.; Champagne, A.; Holdsworth, S. J.; Zwanenburg, J. J. M.

10.1101/2023.01.24.525340 — neuroscience — Posted on 2023-01-24

1025 Description of three new species of predatory Genus Hexacentrus (Orthoptera: Tettigoniidae) from India, with bioacoustic and morphological characterization.

Ghosh, A.; JAISWARA, R.; MOON, M.; DASOJU, V.; SABHARWAL, S.; BHATTACHARJEE, A.; Rajaraman, B. K.

10.1101/2023.01.24.525294 — zoology — Posted on 2023-01-24

1026 Topological design principle for the robustness of necroptosis biphasic, emergent, and coexistent (BEC) dynamics

Xu, F.; Li, X.; Wu, R.; Qi, H.; Jin, J.; Liu, Z.; Wu, Y.; Lin, H.; Shen, C.; Shuai, J.

10.1101/2023.01.23.525173 — systems biology — Posted on 2023-01-24

1027 Investigating the effect of changes in model parameters on optimal control policies, time to absorption, and mixing times

Johnson, K.; Plaugher, D. R.; Murrugarra, D.

10.1101/2023.01.23.525286 — systems biology — Posted on 2023-01-24

1028 Natural methylation epialleles correlate with gene expression in maize

Zeng, Y.; Dawe, R. K.; Gent, J.

10.1101/2023.01.23.525249 — plant biology — Posted on 2023-01-24

1029 Plasma membrane association and resistosome formation of plant helper immune receptors

Wang, Z.; Liu, X.; Yu, J.; Yin, S.; Cai, W.-J.; Kim, N. H.; Kasmi, F. E.; Dangl, J. L.; Wan, L.

10.1101/2023.01.23.525201 — plant biology — Posted on 2023-01-24

1030 Redox-mediated activation of ATG3 promotes ATG8 lipidation and autophagy progression in Chlamydomonas

Mallen-Ponce, M. J.; Perez-Perez, M. E.

10.1101/2023.01.24.525316 — plant biology — Posted on 2023-01-24

1031 Regulation of the hypertonic stress response by the 3' mRNA cleavage and polyadenylation complex

Lamitina, T.; Urso, S.; Sathaseevan, A.; Derry, W. B.

10.1101/2023.01.23.525244 — physiology — Posted on 2023-01-24

1032 Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport

Cacheux, J.; Bancaud, A.; Alcaide, D.; Suehiro, J.-i.; Akimoto, Y.; Sakurai, H.; Matsunaga, Y. T.

10.1101/2023.01.24.525266 — biophysics — Posted on 2023-01-24

1033 PolyAMiner-Bulk: A Machine Learning Based Bioinformatics Algorithm to Infer and Decode Alternative Polyadenylation Dynamics from bulk RNA-seq data

Jonnakuti, V. S.; Wagner, E. J.; Maletic-Savatic, M.; Liu, Z.; Yalamanchili, H. K.

10.1101/2023.01.23.523471 — bioinformatics — Posted on 2023-01-24

1034 Delineation of complex gene expression patterns in single cell RNA-seq data with ICARUS v2.0

Jiang, A.; You, L.; Snell, R. G.; Lehnert, K.

10.1101/2023.01.23.525100 — bioinformatics — Posted on 2023-01-24

1035 Utility of long-read sequencing for All of Us

Mahmoud, M.; Huang, Y.; Garimella, K.; Audano, P. A.; Wan, W.; Prasad, N.; Handsaker, R. E.; Hall, S.; Pionzio, A.; Schatz, M. C.; Talkowski, M. E.; Eichler, E. E.; Levy, S. E.; Sedlazeck, F. J.

10.1101/2023.01.23.525236 — bioinformatics — Posted on 2023-01-24

1036 Quantifying paddling kinematic through muscle activation and whole body coordination during maximal sprint of different duration on a kayak ergometer: a pilot study

Garnier, Y. M.; Hilt, P. M.; Sirandre, C.; Ballay, Y.; Lepers, R.; Paizis, C.

10.1101/2023.01.23.525293 — bioengineering — Posted on 2023-01-24

1037 Conformationally Adaptive Dyes Enable Protein-Adaptive Differential Scanning Fluorometry

Wu, T. S.; Yu, J. C.; Suresh, A.; Gale-Day, Z. J.; Alteen, M. G.; Woo, A. S.; Millbern, Z.; Johnson, O. T.; Carroll, E. C.; Partch, C. L.; Fourches, D.; Vilnueza, N. R.; Vocadlo, D. J.; Gestwicki, J. E.

10.1101/2023.01.23.525251 — biochemistry — Posted on 2023-01-24

1038 The Effect of Glycerol on Microbial Community in Industrial Wastewater Treatment Plant

Prawira Negara, M. A.; Jayawardhana, B.; Euverink, G.-J. W.

10.1101/2023.01.23.525285 — biochemistry — Posted on 2023-01-24

1039 Improvements to the Gulf Pipefish Syngnathus scovelli Genome

Ramesh, B.; Small, C.; Healey, H.; Johnson, B.; Barker, E.; Currey, M.; Bassham, S.; Myers, M.; Cresko, W.; Jones, A.

10.1101/2023.01.23.525209 — genomics — Posted on 2023-01-24

1040 Exploring the genetic diversity of the Japanese Population: Insights from a Large-Scale Whole Genome Sequencing Analysis

10.1101/2023.01.23.525133 — genomics — Posted on 2023-01-24

1041 Development and Implementation of Novel Chatbot-based Genomic Research Consent

Smith, E. D.; Savage, S. K.; Andrew, E. H.; Mas Martin, G.; Kahn-Kirby, A. H.; LoTempio, J.; Delot, E.; Cohen, A. J.; Pitsava, G.; Berger, S.; Fusaro, V.; Vilain, E.

10.1101/2023.01.23.525221 — genetics — Posted on 2023-01-24

1042 All Quiet on the Western Front? The evolutionary history of monogeneans (Dactylogyridae: Cichlidogyrus, Onchobdella) infecting a West and Central African tribe of cichlid fishes (Chromidotilapiini)

Moons, T.; Kmentova, N.; Pariselle, A.; Artois, T.; Bert, W.; Vanhove, M. P. M.; Cruz-Laufer, A. J.

10.1101/2023.01.23.525183 — evolutionary biology — Posted on 2023-01-24

1043 Robust and fast multicolor Single Molecule Localization Microscopy using spectral separation and demixing

Friedl, K.; Mau, A.; Caorsi, V.; Bourg, N.; Leveque-Fort, S.; Leterrier, C.

10.1101/2023.01.23.525017 — cell biology — Posted on 2023-01-24

1044 The Sin3B chromatin modifier restricts cell cycle progression to dictate hematopoietic stem cell differentiation

Calderon, A.; Mestvirishvili, T.; Boccalatte, F.; Ruggles, K.; David, G.

10.1101/2023.01.23.525185 — cell biology — Posted on 2023-01-24

1045 Endothelial vacuole membrane enriched aquaporins regulate microvascular lumenization in development and hyperglycemia

Chen, C.; Qin, Y.; Xu, Y.; Chen, L.; Wang, L.; Liu, D.

10.1101/2023.01.23.525218 — cell biology — Posted on 2023-01-24

1046 rRNA intermediates coordinate the multilayered nucleolar phase transition in C. elegans

Guang, S.; Xu, D.; Chen, X.

10.1101/2023.01.23.525268 — cell biology — Posted on 2023-01-24

1047 Zika virus dumbbell-1 structure is critical for sfRNA presence and cytopathic effect during infection

Graham, M. E.; Merrick, C.; Akiyama, B. M.; Szucs, M.; Leach, S.; Kieft, J. S.; Beckham, J. D.

10.1101/2023.01.23.525127 — microbiology — Posted on 2023-01-24

1048 Mechanism of glycoform specificity and protection against antibody dependent enhancement by an anti-afucosylated IgG nanobody

Gupta, A.; Kao, K. S.; Yamin, R.; Oren, D. A.; Golgur, Y.; Du, J.; Lollar, P.; Sundberg, E.; Ravetch, J. V.

10.1101/2023.01.23.525277 — immunology — Posted on 2023-01-24

1049 RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection

Lindman, M.; Angel, J. P.; Estevez, I.; Chang, N. P.; Chou, T.-W.; McCourt, M.; Atkins, C.; Daniels, B. P.

10.1101/2023.01.23.525284 — immunology — Posted on 2023-01-24

1050 The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis

Akbarain, F.; Rossi, C.; Costers, L.; Dhooghe, M.; Dhaeseleer, M.; Nagels, G.; Van Schependom, J.

10.1101/2023.01.23.525139 — neuroscience — Posted on 2023-01-24

1051 Transcriptomic profiling of retinal cells reveals a subpopulation of microglia/macrophages expressing Rbpms and Spp1 markers of retinal ganglion cells (RGCs) that confound identification of RGCs

Theune, W. C.; Trakhtenberg, E. F.

10.1101/2023.01.23.525216 — neuroscience — Posted on 2023-01-24

1052 Protocol for mapping of the supplementary motor area using repetitive navigated transcranial magnetic stimulation

Engelhardt, M. J.; Kern, G.; Karhu, J.; Picht, T.

10.1101/2023.01.23.525160 — neuroscience — Posted on 2023-01-24

1053 A systematic comparison of VBM pipelines and their application to age prediction

Antonopoulos, G.; More, S.; Raimondo, F.; Eickhoff, S. B.; Hoffstaedter, F.; Patil, K. R.

10.1101/2023.01.23.525151 — neuroscience — Posted on 2023-01-24

1054 Pictorial balance is a bottom-up aesthetic property mediated by eye movements. A model of a primitive visual operating system explains balance and visual properties of pictures

Corwin, D. M.

10.1101/2020.05.26.104687 — neuroscience — Posted on 2023-01-24

1055 ProT-VAE: Protein Transformer Variational AutoEncoder for Functional Protein Design

Sevgen, E.; Moller, J.; Lange, A.; Parker, J.; Quigley, S.; Mayer, J.; Srivastava, P.; Gayatri, S.; Hosfield, D.; Korshunova, M.; Livne, M.; Gill, M.; Ranganathan, R.; Costa, A. B.; Ferguson, A. L.

10.1101/2023.01.23.525232 — synthetic biology — Posted on 2023-01-24

1056 AGAMOUS mediates timing of guard cell formation during gynoecium development

Brazel, A. J.; Fattorini, R.; McCarthy, J.; Franzen, R.; Rümpler, F.; Coupland, G.; O'Maoileidigh, D. S.

10.1101/2023.01.23.525231 — plant biology — Posted on 2023-01-24

1057 Protein semisynthesis underscores role of a conserved lysine in activation and desensitization of acid-sensing ion channels

Sarkar, D.; Galleano, I.; Ou, S. Y.; Uzun, G. R.; Khoo, K. K.; van Noort, G. J. v. d. H.; Pless, S. A.

10.1101/2023.01.23.525296 — biophysics — Posted on 2023-01-24

1058 Explain-seq: an end-to-end pipeline from training to interpretation of sequence-based deep learning models

Zhao, N.; Wang, S.; Huang, Q.; Dong, S.; Boyle, A. P.

10.1101/2023.01.23.525250 — bioinformatics — Posted on 2023-01-24

1059 Tomographic volumetric bioprinting of 3D pancreatic cancer models

Sgarminato, V.; Madrid-Wolff, J.; Boniface, A.; Ciardelli, G.; Tonda-Turo, C.; Moser, C.

10.1101/2023.01.23.525142 — bioengineering — Posted on 2023-01-24

1060 Caf1 regulates Ash1 histone methyltransferase activity via sensing unmodified histone H3.

Yoon, E.; Song, J.-J.

10.1101/2023.01.24.525315 — biochemistry — Posted on 2023-01-24

1061 Distant sequence regions of JBP1 contribute to J-DNA binding

de Vries, I.; Ammerlaan, D.; Heidebrecht, T.; Celie, P.; Geerke, D.; Joosten, R.; Perrakis, A.

10.1101/2023.01.23.525147 — biochemistry — Posted on 2023-01-24

1062 Coding-sequence evolution does not explain divergence in petal anthocyanin pigmentation between Mimulus luteus var. luteus and M. l. variegatus

Orr, W. E.; Kim, J. Y.; Raj, T.; Hom, E. K.; Person, A. E.; Vonada, A.; Stratton, J. A.; Cooley, A. M.

10.1101/2022.12.11.519905 — molecular biology — Posted on 2023-01-24

1063 Preclinical efficacy, safety, and immunogenicity of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2

10.1101/2021.11.22.469117 — immunology — Posted on 2023-01-24

1064 Network structure influences the strength of learned neural representations

Kahn, A. E.; Szymula, K.; Bassett, D. S.; Nyema, N.; Haggerty, E. B.; Aguirre, G. K.

10.1101/2023.01.23.525254 — neuroscience — Posted on 2023-01-24

1065 Transcranial focused ultrasound to rIFG improves response inhibition through modulation of the P300 onset latency

Fine, J. M.; Fini, M. E.; Mysore, A. S.; Tyler, W. J.; Santello, M.

10.1101/649665 — neuroscience — Posted on 2023-01-24

1066 Genome expansion by a CRISPR trimmer-integrase

Wang, J. Y.; Tuck, O. T.; Skopintsev, P.; Soczek, K. M.; Li, G.; Al-Shayeb, B.; Zhou, J.; Doudna, J. A.

10.1101/2023.01.23.522648 — biochemistry — Posted on 2023-01-24

1067 Molecular Investigations of Selected Spike Protein Mutations in SARS-CoV-2: Delta and Omicron Variants and Omicron Subvariants

Roy, U.

10.1101/2022.05.25.493484 — biochemistry — Posted on 2023-01-24

1068 A transcriptional and regulatory map of mouse somitogenesis

Ibarra-Soria, X.; Thierion, E.; Mok, G. F.; Munsterberg, A.; Odom, D. T.; Marioni, J.

10.1101/2023.01.24.525253 — developmental biology — Posted on 2023-01-24

1069 Cellular and Synaptic Diversity of Layer 2-3 Pyramidal Neurons in Human Individuals

Planert, H.; Mittermaier, F. X.; Grosser, S.; Fidzinski, P.; Schneider, U. C.; Radbruch, H.; Onken, J.; Holtkamp, M.; Schmitz, D.; Alle, H.; Vida, I.; Geiger, J. R. P.; Peng, Y.

10.1101/2021.11.08.467668 — neuroscience — Posted on 2023-01-24

1070 Early maturation of sound duration processing in the infant brain

Polver, S.; Toth, B.; Haaden, G. P.; Bulf, H.; Winkler, I.

10.1101/2023.01.24.525349 — neuroscience — Posted on 2023-01-24

1071 Crb3 stabilizes activated Ezrin-Radixin-Moesin to organize the apical domain of multiciliated cells

Burckle, C.; Raitiere, J.; Kodjabachian, L.; Le-Bivic, A.

10.1101/2023.01.24.525309 — cell biology — Posted on 2023-01-24

1072 DNA methylation site loss for plasticity-led novel trait genetic fixation

Katsumura, T.; Sato, S.; Yamashita, K.; Oda, S.; Gakuhari, T.; Tanaka, S.; Fujitani, K.; Nishimaki, T.; Imai, T.; Yoshiura, Y.; Takeshima, H.; Hashiguchi, Y.; Sekita, Y.; Mitani, H.; Ogawa, M.; Takeuchi, H.; Oota, H.

10.1101/2020.07.09.194738 — evolutionary biology — Posted on 2023-01-24

1073 A highly discriminatory RNA strand-specific assay to facilitate analysis of the role of cis-acting elements in foot-and-mouth disease virus replication

Dobson, S. J.; Ward, J. C.; Herod, M. R.; Rowlands, D. R.; Stonehouse, N. J.

10.1101/2023.01.20.524889 — molecular biology — Posted on 2023-01-24

1074 Phylogroup-specific variation shapes the clustering of antimicrobial resistance genes and defence systems across regions of genome plasticity

Botelho, J.; Tüffers, L.; Fuss, J.; Buchholz, F.; Utpatel, C.; Klockgether, J.; Niemann, S.; Tümmler, B.; Schulenburg, H.

10.1101/2022.04.24.489302 — microbiology — Posted on 2023-01-24

1075 Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity via enlarged endosomal vesicles.

Khalili, D.; Kunc, M.; Herbrich, S.; Mueller, A. M.; Theopold, U.

10.1101/2022.08.17.504232 — cancer biology — Posted on 2023-01-24

1076 Impact of cross-ancestry genetic architecture on GWAS in admixed populations

Mester, R.; Hou, K.; Ding, Y.; Meeks, G.; Burch, K. S.; Bhattacharya, A.; Henn, B. M.; Pasaniuc, B.

10.1101/2023.01.20.524946 — bioinformatics — Posted on 2023-01-24

1077 Systematically characterizing the roles of E3-ligase family members in inflammatory responses with massively parallel Perturb-seq

Geiger-Schuller, K. R.; Eraslan, B.; Kuksenko, O.; Dey, K. K.; Jagadeesh, K.; Thakore, P. I.; Karayel, O.; Yung, A. R.; Rajagopalan, A.; Meireles, A. M.; Yang, K. D.; Amir-Zilberstein, L.; Delorey, T. M.; Phillips, D.; Raychowdhury, R.; Moussion, C.; Price, A.; Hacohen, N.; Doench, J. G.; Uhler, C.; Rozenblatt-Rosen, O.; Regev, A.

10.1101/2023.01.23.525198 — genomics — Posted on 2023-01-24

1078 From cell size and first principles to structure and function of unicellular plankton communities

Andersen, K. H.; Visser, A. W.

10.1101/2022.05.16.492092 — ecology — Posted on 2023-01-24

1079 White matter microstructure is associated with the precision of visual working memory

Li, X.; Rangelov, D.; Mattingley, J. B.; Oestreich, L. K. L.; Levy-Bencheton, D.; O'Sullivan, M. J.

10.1101/2023.01.23.525278 — neuroscience — Posted on 2023-01-24

1080 A class-specific effect of dysmyelination on the excitability of hippocampal interneurons

Pinatel, D.; Pearlstein, E.; Bonetto, G.; Goutebroze, L.; Karagogeos, D.; Crepel, V.; Faivre-Sarrailh, C.

10.1101/2023.01.10.523413 — neuroscience — Posted on 2023-01-24

1081 A stochastic world model on gravity for stability inference

Huang, T.; Liu, J.

10.1101/2022.12.30.522364 — neuroscience — Posted on 2023-01-24

1082 A multi-kingdom genetic barcoding system for precise target clone isolation

Ishiguro, S.; Ishida, K.; Sakata, R. C.; Mori, H.; Takana, M.; King, S.; Bashth, O.; Ichiraku, M.; Masuyama, N.; Takimoto, R.; Kijima, Y.; Adel, A.; Toyoshima, H.; Seki, M.; Oh, J. H.; Archambault, A.-S.; Nishida, K.; Kondo, A.; Kuhara, S.; Aburatani, H.; Klein Geltink, R. I.; Takashima, Y.; Shakiba, N.; Yachie, N.

10.1101/2023.01.18.524633 — synthetic biology — Posted on 2023-01-24

1083 A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS

Irwin, K. E.; Jasin, P.; Braunstein, K. E.; Sinha, I.; Bowden, K. D.; Moghekar, A.; Oh, E. S.; Raitcheva, D.; Bartlett, D.; Berry, J. D.; Traynor, B.; Ling, J. P.; Wong, P. C.

10.1101/2023.01.23.525202 — molecular biology — Posted on 2023-01-24

1084 Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons

Boyd, R. J.; McClymont, S. A.; Barrientos, N. B.; Hook, P. W.; Law, W. D.; Rose, R. J.; Waite, E. L.; Avramopoulos, D.; McCallion, A. S.

10.1101/2023.01.23.525270 — genetics — Posted on 2023-01-24

1085 Identification of a mitochondrial targeting sequence in cathepsin D and its localization in mitochondria

Ikari, N.; Arakawa, H.

10.1101/2023.01.23.524639 — cell biology — Posted on 2023-01-24

1086 DRACC1, a major postsynaptic protein, regulates the condensation of postsynaptic proteins via liquid-liquid phase separation

Kaizuka, T.; Hirouchi, T.; Saneyoshi, T.; Hayashi, Y.; Takumi, T.

10.1101/2023.01.23.525126 — neuroscience — Posted on 2023-01-24

1087 Tug-of-peace: Visual Rivalry and Atypical Visual Motion Processing in MECP2 Duplication Syndrome of Autism

Bogatova, D.; Smirnakis, S.; Palagina, G.

10.1101/2022.09.23.509144 — neuroscience — Posted on 2023-01-23

1088 Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel

Sumino, A.; Zhao, Y.; Mukai, D.; Sumikama, T.; Puppulin, L.; Hattori, M.; Shibata, M.

10.1101/2023.01.22.525118 — physiology — Posted on 2023-01-23

1089 Mesenchymal stromal cells and alpha-1 antitrypsin have a strong synergy in modulating inflammation and its resolution

Han, L.; Wu, X.; Wang, O.; Luan, X.; Velander, W. H.; Aynardi, M.; Halstead, E. S.; Bonavia, A.; Jin, R.; Li, G.; Li, Y.; Wang, Y.; Dong, C.; Lei, Y.

10.1101/2022.11.19.517148 — bioengineering — Posted on 2023-01-23

1090 A harmonized public resource of deeply sequenced diverse human genomes

Koenig, Z.; Yohannes, M. T.; Nkambule, L. L.; Goodrich, J. K.; Kim, H. A.; Zhao, X.; Wilson, M. W.; Tiao, G.; Hao, S. P.; Sahakian, N.; Chao, K. R.; gnomAD Project Consortium, ; Talkowski, M. E.; Daly, M. J.; Brand, H.; Karczewski, K.; Atkinson, E. G.; Martin, A.

10.1101/2023.01.23.525248 — genomics — Posted on 2023-01-23

1091 Metabolic responses to food and temperature in deep-sea isopods, Bathynomus doederleini

Shogo, T.; Yurika, O.; Shin-ichiro, T.; Toru, M.; Shingo, F.; Yagi, M.

10.1101/2023.01.23.525261 — ecology — Posted on 2023-01-23

1092 Endogenous inflammatory mediators produced by injury activate TRPV1 and TRPA1 nociceptors to induce sexually dimorphic cold pain that is dependent on TRPM8 and GFRalpha3

Yang, C.; Yamaki, S.; Jung, T.; Kim, B.; Huynh, R.; McKemy, D. D.

10.1101/2023.01.23.525238 — neuroscience — Posted on 2023-01-23

1093 Limits on Inferring Gene Regulatory Networks Subjected to Different Noise Mechanisms

Saint-Antoine, M. M.; Singh, A.

10.1101/2023.01.23.525259 — systems biology — Posted on 2023-01-23

1094 The pGinger family of expression plasmids

Pearson, A. N.; Thompson, M.; Kirkpatrick, L.; Ho, C.; Vuu, K. M.; Waldburger, L.; Keasling, J. D.; Shih, P. M.

10.1101/2023.01.23.524619 — synthetic biology — Posted on 2023-01-23

1095 Structurally complex osteosarcoma genomes exhibit limited heterogeneity within individual tumors and across evolutionary time

Rajan, S.; Zaccaria, S.; Cannon, M. V.; Cam, M.; Gross, A. C.; Raphael, B. J.; Roberts, R. D.

10.1101/2021.08.30.458268 — cancer biology — Posted on 2023-01-23

1096 Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP·Kap114·H2A-H2B complex

Jiou, J.; Shaffer, J. M.; Bernardes, N.; Fung, H. Y. J.; Kikumoto Dias, J.; D'Arcy, S.; Chook, Y. M.

10.1101/2022.11.22.517512 — biochemistry — Posted on 2023-01-23

1097 Disease-associated regulatory variation often displays plasticity or temporal-specificity in fetal pancreas

Nguyen, J. P.; Arthur, T. D.; Fujita, K.; Salgado, B. M.; Donovan, M. K. R.; Matsui, H.; D'Antonio-Chronowska, A.; D'Antonio, M.; Frazer, K. A.

10.1101/2021.03.17.435846 — genomics — Posted on 2023-01-23

1098 Detecting cultural evolution in a songbird species using community-science data and computational modeling

Pichkar, Y.; Searfoss, A. M.; Creanza, N.

10.1101/2023.01.23.525255 — evolutionary biology — Posted on 2023-01-23

1099 Neural dynamics in the rodent motor cortex enables flexible control of vocal timing

Banerjee, A.; Chen, F.; Druckmann, S.; Long, M. A.

10.1101/2023.01.23.525252 — neuroscience — Posted on 2023-01-23

1100 Local production of reactive oxygen species drives vincristine-induced axon degeneration

Gomez-Deza, J.; Slavutsky, A. L.; Nebiyou, M.; Le Pichon, C.

10.1101/2022.07.30.501173 — neuroscience — Posted on 2023-01-23

1101 Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory and is neuroprotective in non-rodents

Rumian, N. L.; Brown, C. N.; Hendry-Hofer, T. B.; Rossetti, T.; Orfila, J. E.; Tullis, J. E.; Dwoskin, L. P.; Asfaha, O.; Lisman, J. E.; Quillinan, N.; Herson, P. S.; Bebarta, V. S.; Bayer, K. U.

10.1101/2023.01.23.523316 — neuroscience — Posted on 2023-01-23

1102 A reliable and efficient adaptive Bayesian method to assess static lower limb proprioception.

Wood, J. M.; Morton, S. M.; Kim, H. E.

10.1101/2023.01.23.525102 — neuroscience — Posted on 2023-01-23

1103 Rhythmically bursting songbird vocomotor neurons are organized into multiple sequences, suggesting a network/intrinsic properties model encoding song and error, not time

Fetterman, G. C.; Margoliash, D.

10.1101/2023.01.23.525213 — neuroscience — Posted on 2023-01-23

1104 Neurophysiological signatures of cortical micro-architecture

Shafiei, G.; Fulcher, B. D.; Voytek, B.; Satterthwaite, T. D.; Baillet, S.; Misic, B.

10.1101/2023.01.23.525101 — neuroscience — Posted on 2023-01-23

1105 PIC recruitment by synthetic reader-actuators to polycomb-silenced genes blocks triple-negative breast cancer invasion

Williams, N. L.; Hong, L.; Jaffe, M.; Shields, C. E.; Haynes, K. A.

10.1101/2023.01.23.525196 — synthetic biology — Posted on 2023-01-23

1106 Lung infection by P. aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice

Villalba, N.; Ma, Y.; Gahan, S. A.; Joly-Amado, A.; Spence, S.; Yang, X.; Nash, K.; Yuan, S. Y.

10.1101/2023.01.23.524949 — pharmacology and toxicology — Posted on 2023-01-23

1107 PKM2 diverts glycolytic flux in dependence on formate overflow

Benzarti, M.; Oudin, A.; Viry, E.; Gargiulo, E.; Schmoetten, M.; Neises, L.; Pulido, C.; Lorenz, N. I.; Ronellenfitsch, M. W.; Sumpton, D.; Warmoes, M.; Jaeger, C.; Lesur, A.; Paggetti, J.; Moussay, E.; Niclou, S. P.; Letellier, E.; Meiser, J.

10.1101/2023.01.23.525168 — cancer biology — Posted on 2023-01-23

1108 Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance

Thatikonda, V.; Lu, H.; Jurado, S.; Kostyrko, K.; Bristow, C. A.; Bosch, K.; Feng, N.; Gao, S.; Gerlach, D.; Gerlach, M.; Lieb, S.; Jeschko, A.; Machado, A. A.; Marszalek, E. D.; Mahendra, M.; Jaeger, P. A.; Sorokin, A.; Strauss, S.; Trapani, F.; Kopetz, S.; Vellano, C. P.; Petronczki, M.; Kraut, N.; Heffernan, T. P.; Marszalek, J. R.; Pearson, M.; Waizenegger, I.; Hofmann, M. H.

10.1101/2023.01.23.525210 — cancer biology — Posted on 2023-01-23

1109 In silico Antibody-Peptide Epitope prediction for Personalized cancer therapy

Jacobs, I.; Lim, C. M.; Emmanoil, M.; Malik, N.

10.1101/2023.01.23.525181 — cancer biology — Posted on 2023-01-23

1110 DOPA residues endow collagen with radical scavenging capacity

Kurth, M.; Barayeu, U.; Gharibi, H.; Kuzhelev, A.; Riedmiller, K.; Zilke, J.; Noack, K.; Denysenkov, V.; Kappl, R.; Prisner, T. F.; Zubarev, R. A.; Dick, T. P.; Graeter, F.

10.1101/2023.01.23.524231 — biophysics — Posted on 2023-01-23

1111 Pan-cancer Proteomics Analysis to Identify Tumor-Enriched and Highly Expressed Cell Surface Antigens as Potential Targets for Cancer Therapeutics

Wang, J.; Yu, W.; DAnna, R.; Przybyla, A.; Wilson, M.; Sung, M.; Bullen, J.; Hurt, E.; DAngelo, G.; Sidders, B.; Lai, Z.; Zhong, W.

10.1101/2023.01.23.525265 — bioinformatics — Posted on 2023-01-23

1112 Autofluorescence lifetime imaging classifies human lymphocyte activation and subtype

Schmitz, R. L.; Tweed, K. E.; Rehani, P.; Samimi, K.; Riendeau, J.; Jones, I.; Maly, E. M.; Guzman, E. C.; Forsberg, M. H.; Shahi, A.; Capitini, C. M.; Walsh, A. J.; Skala, M. C.

10.1101/2023.01.23.525260 — bioengineering — Posted on 2023-01-23

1113 The sound of restored soil: Measuring soil biodiversity in a forest restoration chronosequence with ecoacoustics

Robinson, J. M.; Breed, M.; Abrahams, C.

10.1101/2023.01.23.525240 — ecology — Posted on 2023-01-23

1114 Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion

White, M. J.; Jacobs, K. A.; Singh, T.; Kutys, M. L.

10.1101/2023.01.23.524428 — cell biology — Posted on 2023-01-23

1115 Molecular Interactions and Forces that Make Proteins Stable: A Quantitative Inventory from Atomistic Molecular Dynamics Simulations

Galano-Frutos, J. J.; Sancho, J.

10.1101/2023.01.23.525230 — molecular biology — Posted on 2023-01-23

1116 The biological activity of bacterial rhamnolipids is linked to their molecular structure

Bredenbruch, S.; Mueller, C.; Atemnkeng, H.; Schroeder, L.; Tiso, T.; Blank, L. M.; Grundler, F. M. W.; Schleker, A. S. S.

10.1101/2023.01.23.525263 — molecular biology — Posted on 2023-01-23

1117 Direct Tests of Cytochrome Function in the Electron Transport Chain of Malaria Parasites

Espino-Sanchez, T. J.; Wienkers, H.; Marvin, R. G.; Nalder, S.-a.; Garcia-Guerrero, A. E.; VanNatta, P. E.; Jami-Alahmadi, Y.; Blackwell, A. M.; Whitby, F. G.; Wohlschlegel, J. A.; Kieber-Emmons, M. T.; Hill, C. P.; Sigala, P. A.

10.1101/2023.01.23.525242 — microbiology — Posted on 2023-01-23

1118 Nanocrystalline silver layer of knitted polyester outperforms other silver-containing wound dressings in an in vitro wound model

Hus, J.; Frausto, R. F.; Grunhut, J.; Hus, N. J.

10.1101/2023.01.23.524940 — microbiology — Posted on 2023-01-23

1119 Foraging on host synthesized metabolites enables the bacterial symbiont Snodgrassella alvi to colonize the honey bee gut

Quinn, A.; El Chazli, Y.; Escrig, S.; Daraspe, J.; Neuschwander, N.; McNally, A.; Genoud, C.; Meibom, A.; Engel, P.

10.1101/2023.01.23.524906 — microbiology — Posted on 2023-01-23

1120 Soybean and cotton spermosphere soil microbiome shows dominance of soil-borne copiotrophs

Olofintila, O. E.; Noel, Z. A.

10.1101/2023.01.23.525219 — microbiology — Posted on 2023-01-23

1121 BRWD1 orchestrates chromatin topology by converting static to dynamic cohesin complexes

Mandal, M.; Maienschein-Cline, M.; Hu, Y.; Mohsin, A.; Veselits, M. L.; Wright, N. E.; Okoreeh, M. K.; Yoon, Y. m.; Veselits, J.; Georgopoulos, K.; Clark, M.

10.1101/2023.01.23.525212 — immunology — Posted on 2023-01-23

1122 Assessment of levamisole HCl and thymosin α1 in two mouse models of amyotrophic lateral sclerosis

Borchelt, D. R.; Ellison, S.

10.1101/2023.01.23.525258 — neuroscience — Posted on 2023-01-23

1123 A Model-Based Hierarchical Bayesian Approach to Sholl Analysis

VonKaenel, E.; Feidler, A.; Lowery, R.; Andersh, K.; Love, T.; Majewska, A.; McCall, M. N.

10.1101/2023.01.23.525256 — neuroscience — Posted on 2023-01-23

1124 Site-specific Covalent Labeling of DNA Substrates by an RNA Transglycosylase

Tota, E. M.; Devaraj, N. K.

10.1101/2023.01.23.525207 — synthetic biology — Posted on 2023-01-23

1125 Stretchable, nano-crumpled MXene multilayers impart long-term antibacterial surface properties

Nagpal, N.; Tokmedash, M. A.; Chen, P.-Y.; VanEpps, J. S.; Min, J.

10.1101/2023.01.23.525034 — bioengineering — Posted on 2023-01-23

1126 An empirical assay of view-invariant object learning in humans and baseline image-computable models

Lee, M. J.; DiCarlo, J. J.

10.1101/2022.12.31.522402 — animal behavior and cognition — Posted on 2023-01-23

1127 Prediction of SARS-CoV-2 spike protein mutations using Sequence-to-Sequence and Transformer models

Ahmadi, H.; Nikoofard, V.; Nikoofard, H.; Abdolvahab, R.; Nikoofard, N.; Esmaeilzadeh, M.

10.1101/2023.01.23.525130 — bioinformatics — Posted on 2023-01-23

1128 Effects of structural complexity and water depth on the juvenile blue crab Callinectes sapidus in a simulated salt marsh mesocosm

Hyman, A.; Miller, C.; Shi, D.; Lipcius, R.

10.1101/2023.01.23.524977 — ecology — Posted on 2023-01-23

1129 Failed down-regulation of PI3K signaling makes autoreactive B cells receptive to bystander T cell help.

Fiske, B. E.; Getahun, A.

10.1101/2023.01.23.525206 — immunology — Posted on 2023-01-23

1130 Adaptive robustness through incoherent signaling mechanisms in a regenerative brain

Bray, S. R.; Wyss, L. S.; Chai, C.; Lozada, M. E.; Wang, B.

10.1101/2023.01.20.523817 — neuroscience — Posted on 2023-01-23

1131 Widespread, perception-related information in the human brain scales with levels of consciousness

Vigotsky, A. D.; Jabakhanji, R.; Branco, P.; Iannetti, G. D.; Baliki, M. N.; Apkarian, A. V.

10.1101/2022.09.19.508437 — neuroscience — Posted on 2023-01-23

1132 Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor

Ciampa, E. J.; Flahardy, P.; Srinivasan, H.; Jacobs, C.; Tsai, L.; Karumanchi, S. A.; Parikh, S. M.

10.1101/2022.03.14.483784 — physiology — Posted on 2023-01-23

1133 Formate Promotes Invasion and Metastasis by Activating Fatty Acid Synthesis and Matrix Metalloproteinases

Delbrouck, C.; Kiweler, N.; Pozdeev, V.; Neises, L.; Oudin, A.; Schuster, A.; D'Herouel, A. F.; Shen, R.; Halder, R.; Lesur, A.; Ogris, C.; Lorenz, N.; Jaeger, C.; Ronellenfitsch, M.; Piraud, M.; Skupin, A.; Niclou, S.; Letellier, e.; Meiser, J.

10.1101/2023.01.23.525172 — cancer biology — Posted on 2023-01-23

1134 Cellular mechanisms of heterogeneity in NF2-mutant schwannoma

MacKenzie, C. C.; Vitte, J.; Liu, C. H.; Wright, E. A.; Flynn, E. A.; Stott, S. L.; Giovannini, M.; McClatchey, A. I.

10.1101/2020.12.31.424999 — cancer biology — Posted on 2023-01-23

1135 In-silico Analysis of SARS-Cov2 Spike Proteins of Different Field Variants

Tariq, M. H.; Amir, A.; Ikram, A.

10.1101/2023.01.22.525048 — bioinformatics — Posted on 2023-01-23

1136 CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment

Li, J.; Huang, T.; Hua, J.; Wang, Q.; Su, Y.; Chen, P.; Bidlingmaier, S.; Li, A.; Xie, Z.; Bidkar, A.; Shen, S.; Shi, W.; Seo, Y.; Flavell, R. R.; Gioeli, D.; Dreicer, R.; Li, H.; Liu, B.; He, J.

10.1101/2022.10.14.512321 — bioengineering — Posted on 2023-01-23

1137 A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence

Kang, T.; Moore, E. C.; Kopania, E.; King, C.; Schilling, B.; Campisi, J.; Good, J.; Brem, R.

10.1101/2022.04.21.489100 — genomics — Posted on 2023-01-23

1138 H4K20me3 controls Ash1-mediated H3K36me3 and transcriptional silencing in facultative heterochromatin

Möller, M.; Ridenour, J. B.; Wright, D. F.; Freitag, M.

10.1101/2022.11.25.517763 — genetics — Posted on 2023-01-23

1139 Peptidoglycan remodeling in response to cell wall acting antibiotics in Bacillus subtilis

Cornilleau, C.; Alvarez, L.; Wegler, C.; Billaudeau, C.; Cava, F.; Carballido-Lopez, R.

10.1101/2023.01.23.525174 — microbiology — Posted on 2023-01-23

1140 A New Approach for Active Coronavirus Infection Identification by Targeting the Negative RNA Strand- A Replacement for the Current Positive RNA-based qPCR Detection Method

Davis, D.; Ullah, H.

10.1101/2023.01.22.525117 — microbiology — Posted on 2023-01-23

1141 Dynamic mitochondrial transcription and translation in B cells control germinal centre entry and lymphomagenesis

Yazicioglu, Y. F.; Marin, E. M.; Sandhu, C.; Galiani, S.; Raza, I. G. A.; Ali, M.; Kronsteiner, B.; Compeer, E.; Attar, M.; Dunachie, S.; Dustin, M.; Clarke, A.

10.1101/2022.07.19.500689 — immunology — Posted on 2023-01-23

1142 Basolateral amygdala circuits supporting negative emotional bias in a mouse model for depression

Bigot, M.; De Badts, C.-H.; Benchetrit, A.; Vicq, E.; Moigneu, C.; Meyrel, M.; Wagner, S.; Houenou, J.; Lledo, P.-M.; Henry, C.; ALONSO, M.

10.1101/2023.01.23.525169 — neuroscience — Posted on 2023-01-23

1143 Integration of spatially opposing cues by a single interneuron guides decision making in C. elegans

Gat, A.; Pechuk, V.; Peedikayil-Kurien, S.; Goldman, G.; Lubliner, J.; Karimi, S.; Krieg, M.; Oren-Suissa, M.

10.1101/2023.01.23.525194 — neuroscience — Posted on 2023-01-23

1144 Quantifying Evoked Responses through Encoded Information

Fuhrer, J.; Glette, K.; Llorens, A.; Endestad, T.; Solbakk, A.-K.; Blenkmann, A.

10.1101/2022.11.11.516096 — neuroscience — Posted on 2023-01-23

1145 Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia

Hoq, M. R.; Bharath, S.; Hallinan, G.; Fernandez, A.; Vago, F.; Ozcan, K.; Li, D.; Garringer, H.; Vidal, R.; Ghetti, B.; Jiang, W.

10.1101/2023.01.09.523314 — neuroscience — Posted on 2023-01-23

1146 Hawks pursuing targets through clutter avoid obstacles by applying open loop steering corrections during closed loop pursuit

Brighton, C. H.; Kempton, J. A.; France, L. A.; KleinHeerenbrink, M.; Minano, S.; Taylor, G. K.

10.1101/2023.01.23.525170 — zoology — Posted on 2023-01-23

1147 Compressed phenotypic screens for complex multicellular models and high-content assays

Mead, B. E.; Kummerlowe, C.; Liu, N.; Kattan, W. E.; Cheng, T.; Cheah, J. H.; Soule, C. K.; Peters, J.; Lowder, K. E.; Blainey, P. C.; Hahn, W. C.; Cleary, B.; Bryson, B.; Winter, P. S.; Raghavan, S.; Shalek, A. K.

10.1101/2023.01.23.525189 — systems biology — Posted on 2023-01-23

1148 Compressed Perturb-seq: highly efficient screens for regulatory circuits using random composite perturbations

Yao, D.; Binan, L.; Bezney, J.; Simonton, B.; Freedman, J.; Frangieh, C. J.; Dey, K. K.; Geiger-Schuller, K.; Eraslan, B.; Gusev, A.; Regev, A.; Cleary, B.

10.1101/2023.01.23.525200 — systems biology — Posted on 2023-01-23

1149 A model of decentralized vision in the sea urchin Diadema africanum

Li, T.; Kirwan, J.; Arnone, M. I.; Nilsson, D.-E.; La Camera, G.

10.1101/2022.05.03.490537 — systems biology — Posted on 2023-01-23

1150 A publishing infrastructure for AI-assisted academic authoring

Pividori, M.; Greene, C. S.

10.1101/2023.01.21.525030 — scientific communication and education — Posted on 2023-01-23

1151 Streamlined regulation of chloroplast development in the liverwort Marchantia polymorpha

Yelina, N. E.; Frangedakis, E.; Schreier, T. B.; Rever, J.; Tomaselli, M.; Haseloff, J.; Hibberd, J. M.

10.1101/2023.01.23.525199 — plant biology — Posted on 2023-01-23

1152 miR-203 drives breast cancer cell differentiation

Martinez-Illescas, N. G.; Leal, S.; Gonzalez, P.; Grana, O.; Oliveira, J. J. M.; Pena, A. C.; Fandino, M. Q.; Ciruelos, E.; Sanz, C.; Aragon, S.; Sotolongo, L.; Jimenez, S.; Caleiras, E. J.; Mulero, F.; Sanchez, C.; Malumbres, M.; Salazar-Roa, M.

10.1101/2023.01.23.525208 — cancer biology — Posted on 2023-01-23

1153 Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency

Bretherton, R. C.; Reichardt, I. M.; Zabrecky, K. A.; Goldstein, A. J.; Bailey, L. R. J.; Bugg, D.; McMillen, T. S.; Kooiker, K. B.; Flint, G.; Martinson, A.; Gunaje, J.; Koser, F.; Linke, W. A.; Regnier, M.; Moussavi-Harami, F.; Sniadecki, N. J.; DeForest, C. A.; Davis, J.

10.1101/2023.01.23.523684 — cell biology — Posted on 2023-01-23

1154 Using RNASeq to investigate the involvement of the Ophiocordyceps clock in ant host infection and behavioral manipulation

Das, B.; Will, I.; Brouns, R.; Brachmann, A.; de Bekker, C.

10.1101/2023.01.20.524843 — molecular biology — Posted on 2023-01-23

1155 Waning Immunity Against XBB.1.5 Following Bivalent mRNA Boosters

Lasrado, N.; Collier, A.-r.; Miller, J.; Hachmann, N.; Liu, J.; Sciacca, M.; Wu, C.; Anand, T.; Bondzie, E.; Fisher, J.; Mazurek, C.; Patio, R.; Powers, O.; Rodrigues, S.; Rowe, M.; Surve, N.; Ty, D.; Korber, B.; Barouch, D. H.

10.1101/2023.01.22.525079 — immunology — Posted on 2023-01-23

1156 A Novel Fully Automated MRI-Based Deep Learning Method For Classification Of IDH Mutation Status In Brain Gliomas

Bangalore Yogananda, C. G.; Shah, B. R.; Vejdani-Jahromi, M.; Nalawade, S.; Murugesan, G. K.; Yu, F. F.; Pinho, M. C.; Wagner, B. C.; Mickey, B.; Patel, T.; Fei, B.; Madhuranthakam, A. J.; Maldjian, J. A.

10.1101/757385 — neuroscience — Posted on 2023-01-23

1157 Glutathione transferase photoaffinity labeling demonstrates GST activation by safeners and NPR1-independent activation by BTH

Font Farre, M.; Brown, D.; Konig, M.; Killinger, B. J.; Kaschani, F.; Kaiser, M.; Wright, A. T.; Burton, J.; van der Hoorn, R. A. L.

10.1101/2023.01.19.524829 — plant biology — Posted on 2023-01-23

1158 Lack of Fzd6 in Ciliated Cells Suppresses Ferroptotic Pulmonary Alveolar Cell Death Induced by LPS and Coronavirus

Yuan, Q.; Luan, Y.; Rajendran, B. K.; Compton, S.; Tang, W.; Wu, D.

10.1101/2023.01.23.524390 — pathology — Posted on 2023-01-23

1159 CompCorona: A Web Portal for Comparative Analysis of the Host Transcriptome of PBMC and Lung SARS-CoV-2, SARS-CoV, and MERS-CoV

Salihoglu, R.; Saracoglu, F.; Sibai, M.; Zengin, T.; Abak Masud, B.; Karasoy, O.; Onal-Suzek, T.

10.1101/2023.01.21.524927 — bioinformatics — Posted on 2023-01-23

1160 RNetDys: identification of disease-related impaired regulatory interactions due to SNPs

Barlier, C.; Ribeiro, M. M.; Jung, S.; del Sol Mesa, A.

10.1101/2022.10.08.511312 — bioinformatics — Posted on 2023-01-23

1161 Both behavior-manipulating and non-manipulating entomopathogenic fungi affect rhythmic gene expression in carpenter ant foragers upon infection

Das, B.; Brachmann, A.; de Bekker, C.

10.1101/2023.01.19.524837 — animal behavior and cognition — Posted on 2023-01-23

1162 A modeling study on the impact of COVID-19 pandemic responses on the community transmission of antibiotic-resistant bacteria

Kovacevic, A.; Smith, D. R. M.; Rahbe, E.; Novelli, S.; Henriot, P.; Temime, L.; Opatowski, L.

10.1101/2022.08.08.503267 — ecology — Posted on 2023-01-23

1163 Lipopolysaccharide integrity primes bacterial sensitivity to a cell wall-degrading intermicrobial toxin

Trotta, K. L.; Hayes, B. M.; Schneider, J. P.; Wang, J.; Todor, H.; Rockefeller Grimes, P.; Zhao, Z.; Hatleberg, W.; Silvis, M. R.; Kim, R.; Koo, B.-M.; Basler, M.; Chou, S.

10.1101/2023.01.20.524922 — microbiology — Posted on 2023-01-23

1164 Neutralization of zoonotic retroviruses by human antibodies: genotype-specific epitopes within the receptor-binding domain from simian foamy virus

Dynesen, L. T.; Fernandez, I.; Coquin, Y.; Delaplace, M.; Montange, T.; Njouom, R.; Bilounga-Ndongo, C.; Rey, F. A.; Gessain, A.; Backovic, M.; Buseyne, F.

10.1101/2022.11.06.515319 — microbiology — Posted on 2023-01-23

1165 A Novel Monoclonal Antibody Targeting a Large Surface of the Receptor Binding Motif Shows Pan-neutralizing SARS-CoV-2 Activity Including BQ.1.1 Variant

de Campos-Mata, L.; Trinite, B.; Modrego, A.; Tejedor Vaquero, S.; Pradenas, E.; Rodrigo Melero, N.; Carlero, D.; Marfil, S.; Pons-Grifols, A.; Bueno-Carrasco, M. T.; Santiago, C.; Tarres-Freixas, F.; Urrea, V.; Izquierdo, N.; Riveira-Munoz, E.; Ballana, E.; Perez, M.; Vergara-Alert, J.; Segales, J.; Carolis, C.; Arranz, R.; Blanco, J.; Magri, G.

10.1101/2023.01.20.524748 — immunology — Posted on 2023-01-23

1166 Oxytocin activity in the Paraventricular and Supramammillary Nuclei of the Hypothalamus is Essential for Social Recognition Memory in Rats

Thirtamara Rajamani, K.; Barbier, M.; Lefevre, A.; Niblo, K.; Cordero, N.; Netser, S.; Grinevich, V.; Wagner, S.; Harony-Nicolas, H.

10.1101/2022.05.23.493099 — neuroscience — Posted on 2023-01-23

1167 Finding the LMA needle in the wheat proteome haystack.

Vincent, D.; Bui, A.; Ram, D.; Ezernieks, V.; Shahinfar, S.; Luke, T.; Rochfort, S.; Rigas, N.; Panozzo, J.; Daetwyler, H.; Hayden, M. J.

10.1101/2023.01.22.525108 — plant biology — Posted on 2023-01-23

1168 Three-dimensional imaging and quantification of mouse ovarian follicles via optical coherence tomography

Amaral, M. M.; Sun, A.; Li, Y.; Ren, C.; Truong, A. B.; Nigam, S.; Jiao, Z.; Wang, P.; Zhou, C.

10.1101/2023.01.23.525192 — bioengineering — Posted on 2023-01-23

1169 Telomerase-independent survival leads to a mosaic of complex subtelomere rearrangements in Chlamydomonas reinhardtii

Chaux, F.; Agier, N.; Garrido, C.; Fischer, G.; Eberhard, S.; Xu, Z.

10.1101/2023.01.23.525193 — genomics — Posted on 2023-01-23

1170 In vivo versus in silico assessment of potentially pathogenic missense variants in human reproductive genes

Ding, X.; Singh, P.; Schimenti, K.; Tran, T. N.; Fragoza, R.; Hardy, J.; Orwig, K.; Kurpisz, M. K.; Yatsenko, A.; Conrad, D. F.; Yu, H.; Schimenti, J. C.

10.1101/2021.10.12.464112 — genetics — Posted on 2023-01-23

1171 Mechanism of an alternative splicing switch mediated by cell-specific and general splicing regulators

Smith, C. W. J.; Yang, Y.; Lee, G.; Nakagaki-Silva, E. E.; Huang, Y.; Peacey, M.; Partridge, R.; Gooding, C.

10.1101/2023.01.23.525191 — molecular biology — Posted on 2023-01-23

1172 Bacteriophage therapy for the treatment of Mycobacterium tuberculosis infections in humanized mice

Yi, G.; Yang, F.; Labani-Motlagh, A.; Moreira, J. D.; Ansari, D.; Bohorquez, J. A.; Patel, S.; Spagnolo, F.; Florence, J.; Vankayalapati, A.; Vankayalapati, R.; Dennehy, J. J. D. J.; Samten, B.

10.1101/2023.01.23.525188 — microbiology — Posted on 2023-01-23

1173 Intracellular pH-regulated Cell Intrinsic Control of Death and Proliferation of Lymphocytes in Immune Response and Tumor Cells

Zeng, W.-p.; Yang, S.; Zhou, B.

10.1101/2021.10.29.466539 — immunology — Posted on 2023-01-23

1174 Nonmotor symptoms associated with progressive loss of dopaminergic neurons in a mouse model of Parkinson's disease

Radlicka, A.; Jabłonska, J.; Lenarczyk, M.; Szumiec, Łukasz; Harda, Z.; Baginska, M.; Pera, J.; Kreiner, G.; Wojcik, D. K.; Rodriguez Parkitna, J. M.

10.1101/2023.01.23.525182 — neuroscience — Posted on 2023-01-23

1175 Low frequency optogenetic deep brain stimulation of nucleus accumbens dopamine D1 or D2 receptor-containing neurons attenuates cocaine seeking selectively in male rats in part by reversing synaptic plasticity deficits

Swinford-Jackson, S. E.; Rich, M. T.; Huffman, P. J.; Knouse, M. C.; Thomas, A. S.; Mankame, S.; Worobey, S. J.; Pierce, R. C.

10.1101/2023.01.23.524956 — neuroscience — Posted on 2023-01-23

1176 MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS pathophysiology

Perez-Cabello, J. A.; Franco, J. M.; Silvera-Carrasco, L.; Capilla-Gonzalez, V.; Armaos, A.; Gomez-Lima, M.; Garcia-Garcia, R.; Yap, X. W.; Leal-Lasarte, M. M.; Lall, D.; Baloh, R. H.; Martinez, S.; Miyata, Y.; Tartaglia, G. G.; Sawarkar, R.; Garcia-Dominguez, M.; Pozo, D.; Roodveldt, C.

10.1101/2023.01.23.524851 — neuroscience — Posted on 2023-01-23

1177 The Medicago truncatula nodule-specific cysteine-rich peptides, NCR343 and NCR-new35 are required for the maintenance of rhizobia in nitrogen-fixing nodules.

Horvath, B.; Gungor, B.; Toth, M.; Domonkos, A.; Ayaydin, F.; Saifi, F.; Chen, Y.; Biro, J. B.; Bourge, M.; Szabo, Z.; Toth, Z.; Chen, R.; Kalo, P.

10.1101/2023.01.23.523609 — plant biology — Posted on 2023-01-23

1178 Evidence for noisy oscillations of cAMP under nutritional stress condition in budding yeast

Colombo, S.; Collini, M.; D' Alfonso, L.; Chirico, G.; Martegani, E.

10.1101/2023.01.23.524687 — biophysics — Posted on 2023-01-23

1179 Minuteman - A versatile cloud computational platform for collaborative research

Li, X.; Chakraborty, J.; Jameson, M.; Moore, H.; Biehlmann, A. L.; Hayat, S.; Jain, D.

10.1101/2023.01.21.514916 — bioinformatics — Posted on 2023-01-23

1180 Novel Pipeline for Large-Scale Comparative Population Genetics

Majoros, S. E.; Adamowicz, S. J.; Cottenie, K.

10.1101/2023.01.23.524574 — bioinformatics — Posted on 2023-01-23

1181 The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets

Okuwaki, M.; Ozawa, S.-i.; Ebine, S.; Juichi, M.; Umeki, T.; Niioka, K.; Kikuchi, T.; Tanaka, N.

10.1101/2023.01.23.525122 — biochemistry — Posted on 2023-01-23

1182 Pot1 promotes telomere DNA replication via the Stn1-Ten1 complex in fission yeast

Borges, P. C.; Escandell, J. M.; Matmati, S.; Coulon, S.; Ferreira, M. G.

10.1101/2023.01.23.525167 — genetics — Posted on 2023-01-23

1183 Identification of Candidate Mitochondrial Inheritance Determinants Using the Mammalian Cell-Free System

Zuidema, D.; Jones, A.; Song, W.-H.; Zigo, M.; Sutovsky, P.

10.1101/2023.01.23.525177 — cell biology — Posted on 2023-01-23

1184 A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia

Menin, L.; Weber, J.; Villa, S.; Martini, E.; Maspero, E.; Cancila, V.; Maiuri, P.; Palamidessi, A.; Frittoli, E.; Bianchi, F.; Tripodo, C.; Walters, K.; Giavazzi, F.; Scita, G.; Polo, S.

10.1101/2023.01.23.524898 — cell biology — Posted on 2023-01-23

1185 Epigenetic signature of human immune aging: the GESTALT study.

Roy, R.; Kuo, P.-L.; Candia, J.; Sarantapoulou, D.; Ubaida-Mohien, C.; Hernandez, D.; Kaileh, M.; Arepalli, S.; Singh, A.; Bektas, A.; Kim, J.; Moore, A. Z.; Tanaka, T.; McKelvey, J.; Zukley, L.; Nguyen, C.; Wallace, T.; Dunn, C.; Wood, W.; Piao, Y.; Coletta, C.; De, S.; Sen, J.; Weng, N.-p.; Sen, R.; Ferrucci, L.

10.1101/2023.01.23.525162 — molecular biology — Posted on 2023-01-23

1186 MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses

Heuberger, C.; Janney, A.; Ilott, N.; Bertocchi, A.; Pott, S.; Gu, Y.; Pohin, M.; Friedrich, M.; Mann, E.; Pearson, C.; Powrie, F.; Pott, J.; Thornton, E. E.; Maloy, K. J.

10.1101/2023.01.23.525150 — immunology — Posted on 2023-01-23

1187 N-glycosylation engineering in chimeric antigen receptor T cells enhances anti-tumor activity

De Bousser, E.; Festjens, N.; Meuris, L.; Plets, E.; Van Hecke, A.; Wyseure, E.; De Munter, S.; Vandekerckhove, B.; Callewaert, N.

10.1101/2023.01.23.525164 — immunology — Posted on 2023-01-23

1188 Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

Seddighi, S.; Qi, Y. A.; Brown, A.-L.; Wilkins, O. G.; Bereda, C.; Belair, C.; Zhang, Y.; Prudencio, M.; Keuss, M.; Khandeshi, A.; Pickles, S.; Hill, S.; Hawrot, J.; Ramos, D.; Yuan, H.; Roberts, J.; Kelmer Sacramento, E.; Shah, S.; Nalls, M. A.; Colon-Mercado, J.; Reyes, J.; Ryan, V.; Nelson, M.; Cook, C.; Li, Z.; Screven, L.; Kwan, J.; Shantaraman, A.; Ping, L.; Koike, Y.; Oskarsson, B.; Staff, N.; Duong, D.; Ahmed, A.; Secrier, M.; Ule, J.; Jacobson, S.; Rohrer, J.; Malaspina, A.; Glass, J.; Ori, A.; Seyfried, N.; Maragkakis, M.; Petrucelli, L.; Fratta, P.; Ward, M. E.

10.1101/2023.01.23.525149 — neuroscience — Posted on 2023-01-23

1189 AtOM, an ontology model for standardizing use of brain atlases in tools, workflows, and data infrastructures

Kleven, H.; Gillespie, T. H.; Zehl, L.; Dickscheid, T.; Bjaalie, J. G.; Martone, M. E.; Leergaard, T. B.

10.1101/2023.01.22.525049 — neuroscience — Posted on 2023-01-23

1190 Paradoxical consequences of early hippocampal damage: greater atrophy is associated with better recall, working memory and visuospatial perception in developmental amnesia

Chareyron, L. J.; Chong, K.; Banks, T.; Mishkin, M.; Burgess, N.; Saunders, R. C.; Vargha-Khadem, F.

10.1101/2023.01.23.525152 — neuroscience — Posted on 2023-01-23

1191 Eye movements track prioritized auditory features in selective attention to natural speech

Gehmacher, Q.; Schubert, J.; Schmidt, F.; Hartmann, T.; Reisinger, P.; Roesch, S.; Schwarz, K.; Popov, T.; Chait, M.; Weisz, N.

10.1101/2023.01.23.525171 — neuroscience — Posted on 2023-01-23

1192 A network pharmacology approach to assess the comparative pharmacodynamics of pharmaceutical excipient trehalose in human, mouse and rat

Friend, J.; Kumar, A. H.

10.1101/2023.01.23.525154 — pharmacology and toxicology — Posted on 2023-01-23

1193 EDA2R/NIK signaling promotes skeletal muscle atrophy linked to cancer cachexia

Bilgic, S. N.; Domaniku, A.; Toledo, B.; Agca, S.; Weber, B. Z. C.; Arabaci, D. H.; Ozornek, Z.; Lause, P.; Thissen, J.-P.; Loumaye, A.; Kir, S.

10.1101/2023.01.23.525138 — cancer biology — Posted on 2023-01-23

1194 Multiscale imaging and quantitative analysis of plasma membrane protein-cortical actin interplay

Dasgupta, A.; Ngo, H.-T.; Tschoerner, D.; Touret, N.; da Rocha-Azevedo, B.; Jaqaman, K.

10.1101/2023.01.22.525112 — biophysics — Posted on 2023-01-23

1195 Cont-ID:Detection of samples cross-contamination in viral metagenomic data

Rollin, J.; Rong, W.; Massart, S.

10.1101/2023.01.23.525161 — bioinformatics — Posted on 2023-01-23

1196 Caltubin regulates microtubule stability via Ca2+-dependent mechanisms favouring neurite regrowth

Barszczyk, A.; Bandura, J.; Zhang, Q.; Wang, H.; Deurloo, M.; Ahmed, Y.; Dong, A.; Meister, P.; Lee, J.; Sun, H.-S.; Tong, Y.; Feng, Z.-P.

10.1101/2023.01.23.525163 — cell biology — Posted on 2023-01-23

1197 Heterologous expression of genes from a heterocystous cyanobacterial endosymbiont highlights organic carbon exchange with its diatom host

Nieves-Morion, M.; Camargo, S.; Bardi, S.; Ruiz Perez, M. T.; Flores, E.; Foster, R. A.

10.1101/2023.01.23.525141 — molecular biology — Posted on 2023-01-23

1198 Structural insights into the mechanism of the human SGLT2-MAP17 glucose transporter

Hiraizumi, M.; Akashi, T.; Murasaki, K.; Kishida, H.; Kumanomidou, T.; Torimoto, N.; Nureki, O.; Miyaguchi, I.

10.1101/2023.01.23.524988 — molecular biology — Posted on 2023-01-23

1199 A new cheese population in Penicillium roqueforti and adaptation of the five populations to their ecological niche

Crequer, E.; Ropars, J.; Jany, J.-L.; Caron, T.; Coton, M.; Snirc, A.; Vernadet, J.-P.; Branca, A.; Giraud, T.; Coton, E.

10.1101/2023.01.21.524518 — microbiology — Posted on 2023-01-23

1200 Type VII secretion system and its effect on Group B Streptococcus virulence

Schindler, Y.; Rahav, G.; Nissan, I.; Valenci, G.; Ravins, M.; Hanski, E.; Ment, D.; Tekes-Manova, D.; Maor, Y.

10.1101/2023.01.23.525132 — microbiology — Posted on 2023-01-23

1201 Aspartyl protease in the secretome of honey bee trypanosomatid parasite is essential for the efficient infection of host

Yuan, X.; Sun, J.; Kadowaki, T.

10.1101/2023.01.23.525124 — microbiology — Posted on 2023-01-23

1202 A universal stress protein is essential for the survival of Mycobacterium tuberculosis

Banerjee, A.; Chakraborty, M. M.; Sharma, S.; Chaturvedi, R.; Bose, A.; Biswas, P.; Singh, A.; Visweswariah, S. S.

10.1101/2023.01.23.525157 — microbiology — Posted on 2023-01-23

1203 Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response

Chen, Y.; Quan, S.; Patil, V.; Kunjamma, R. B.; Tokars, H. M.; Leisten, E. D.; Chan, J. R.; Wong, Y.; Popko, B. J.

10.1101/2023.01.23.525156 — neuroscience — Posted on 2023-01-23

1204 Sensory constraints on volitional modulation of the motor cortex

Fisac, C. F.; Chase, S. M.

10.1101/2023.01.22.525098 — neuroscience — Posted on 2023-01-23

1205 Cognitive and neural bases of salience-driven incidental learning

Sun, S.; Yu, H.; Wang, S.; Yu, R.

10.1101/2023.01.23.525123 — neuroscience — Posted on 2023-01-23

1206 Osr40g3 imparts salt tolerance by regulating GF14e-mediated gibberellin metabolism to activate EG45 in rice

Roy, C.; Sahid, S.; Shee, D.; Datta, R.; Paul, S.

10.1101/2020.04.26.062158 — plant biology — Posted on 2023-01-23

1207 Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel

Sumino, A.; Zhao, Y.; Mukai, D.; Sumikama, T.; Puppulin, L.; Hattori, M.; Shibata, M.

10.1101/2023.01.22.525118 — physiology — Posted on 2023-01-23

1208 Charting the Heterogeneity of Colorectal Cancer Consensus Molecular Subtypes using Spatial Transcriptomics

Valdeolivas, A.; Amberg, B.; Giroud, N.; Richardson, M.; Galvez, E. J. C.; Badillo, S.; Julien-Laferriere, A.; Turos, D.; Voith von Voithenberg, L.; Wells, I.; Lo, A. A.; Yangüez, E.; Das Thakur, M.; Bscheider, M.; Sultan, M.; Kumpesa, N.; Jacobsen, B.; Bergauer, T.; Saez-Rodriguez, J.; Rottenberg, S.; Schwalie, P. C.; Hahn, K.

10.1101/2023.01.23.525135 — cancer biology — Posted on 2023-01-23

1209 Defective ribosome assembly impairs leukemia stem cell function in a murine model of acute myeloid leukemia

Sjovall, D.; Ghosh, S.; Hansson, J.; Guibentif, C.; Jaako, P.

10.1101/2023.01.22.525120 — cancer biology — Posted on 2023-01-23

1210 Accurate and interpretable gene expression imputation on scRNA-seq data using IGSimpute

Xu, K.; Cheong, C.; Veldsman, W. P.; Lyu, A.; Cheung, K.; Zhang, L.

10.1101/2023.01.22.525114 — bioinformatics — Posted on 2023-01-23

1211 RawHash: Enabling Fast and Accurate Real-Time Analysis of Raw Nanopore Signals for Large Genomes

Firtina, C.; Ghiasi, N. M.; Lindegger, J.; Singh, G.; Cavlak, M. B.; Mao, H.; Mutlu, O.

10.1101/2023.01.22.525080 — bioinformatics — Posted on 2023-01-23

1212 A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire

Winiarska, A.; Ramirez-Amador, F.; Hege, D.; Gemmecker, Y.; Prinz, S.; Hochberg, G.; Heider, J.; Szaleniec, M.; Schuller, J. M.

10.1101/2023.01.23.525143 — biochemistry — Posted on 2023-01-23

1213 Hydroxyurea inhibits ERAD-L independently of S-phase arrest in budding yeast

Takano, Y.; Nakatsukasa, K.

10.1101/2023.01.22.525111 — biochemistry — Posted on 2023-01-23

1214 Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

Kumar, A.; Vadas, O.; Dos Santos Pacheco, N.; Zhang, X.; Chao, K.; Darvill, N.; Rasmussen, H.; Xu, Y.; Lin, G.; Stylianou, F.; Pedersen, J. S.; Rouse, S.; Morgan, M.; Soldati-Favre, D.; Matthews, S.

10.1101/2023.01.23.525158 — biochemistry — Posted on 2023-01-23

1215 A lizard is never late: squamate genomics as a recent catalyst for understanding microchromosome and sex chromosome evolution

Pinto, B. J.; Gamble, T.; Smith, C. H.; Wilson, M. A.

10.1101/2023.01.20.524006 — genomics — Posted on 2023-01-23

1216 Using inbreeding to test the contribution of non-additive genetic effects to additive genetic variance: a case study in Drosophila serrata

Dugand, R. J.; Blows, M. W.; McGuigan, K.

10.1101/2023.01.22.525104 — evolutionary biology — Posted on 2023-01-23

1217 First record of highly invasive Chinese sleeper Perccottus glenii Dybowski, 1877 (Perciformes: Odontobutidae) in the Elbe River Basin, Czechia

Smejkal, M.; Dockal, O.; Thomas, K.; Kalous, L.

10.1101/2023.01.20.524995 — ecology — Posted on 2023-01-23

1218 Dynamics of Changes in Cadmium Levels in Environmental Objects and its Impact on the Bio-Elemental Composition of Living Organisms

Nechytailo, L.; Danyliv, S.; Kuras, L.; Shkurashivska, S.; Buchko, A.

10.1101/2023.01.22.525090 — ecology — Posted on 2023-01-23

1219 Genomic and Proteomic Analysis of Patients with Reoccurring Discrete Subaortic Stenosis

Birla, R.; Singampalli, K. L.; Nieuwsma, A.; Brimmer, S. A.; Kaul, A.; Wadhwa, L.; Jung, S. Y.; Mezquita, D.; Grimm, S. L.; Balaji, S.; Coarfa, C.; Caldarone, C. A.; Grande-Allen, K. J.; Keswani, S. G.

10.1101/2023.01.22.525022 — molecular biology — Posted on 2023-01-23

1220 Solution-state NMR Assignment and Secondary Structural Propensities of the Full-Length and Minimalistic-Truncated Prefibrillar Monomeric Form of Biofilm-Forming Functional-Amyloid FapC from Pseudomonas aeruginosa

Akbey, U.; Byeon, C.-H.; Byeon, I. J. L.; Wang, P. C.

10.1101/2023.01.22.525107 — microbiology — Posted on 2023-01-23

1221 PNAG exopolysaccharide eradication gives neutrophils access to Staphylococcus aureus biofilm infections

Kratofil, R. M.; Randall, T. E.; Hommes, J. W.; Sejuty, R.; Chisholm, J.; Raju, D.; Vargas, M.; Howell, P. L.; Pier, G. B.; Morck, D. W.; Harrison, J. J.; Kubes, P.

10.1101/2023.01.23.525131 — immunology — Posted on 2023-01-23

1222 Novel gut microbiota and microbiota-metabolites signatures in gliomas and its predictive/prognosis functions

Zhou, M.; Song, C.; Gu, J. W.; Wang, T.; Shi, L. Y.; Li, C. Y.; Zhu, L. W.; Li, H.; Qi, S.; Lu, Y.

10.1101/2023.01.19.524836 — neuroscience — Posted on 2023-01-23

1223 Attentional modulation is orthogonal to disinhibition by VIP interneurons in primary visual cortex

Myers-Joseph, D.; Wilmes, K. A.; Fernandez-Otero, M.; Clopath, C.; Khan, A. G.

10.1101/2022.11.28.518253 — neuroscience — Posted on 2023-01-23

1224 Early frequency-specific contributions to serial-effects in audition

Lieder, I.; Sulem, A.; Ahissar, M.

10.1101/2023.01.22.525097 — neuroscience — Posted on 2023-01-23

1225 4-methylumbelliferone enhances neuroplasticity in the central nervous system: potential oral treatment for SCI

Irvine, S. F.; Gigout, S.; Stepankova, K.; Varea, N. M.; Urdzikova, L. M.; Jendelova, P.; Kwok, J. C. F.

10.1101/2023.01.23.525137 — neuroscience — Posted on 2023-01-23

1226 Evidence for subjective values guiding cognitive integration of gravity in a free speed manifold pointing task

Devemy, A.; Papaxanthis, C.; da Silva Pontes, L.; Pozzo, T.; Hilt, P. M.

10.1101/2023.01.23.525134 — neuroscience — Posted on 2023-01-23

1227 Visual short-term memory related EEG components in a virtual reality setup

Klotzsche, F.; Gaebler, M.; Villringer, A.; Sommer, W.; Nikulin, V. V.; Ohl, S.

10.1101/2023.01.23.525140 — neuroscience — Posted on 2023-01-23

1228 Data Driven Taxonomy for Antipsychotic Medication: A New Classification System

McCutcheon, R. A.; Harrison, P. J.; Howes, O. D.; McGuire, P. K.; Taylor, D.; Pillinger, T.

10.1101/2023.01.23.524854 — pharmacology and toxicology — Posted on 2023-01-23

1229 Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-Institutional Prospective Cohort Evaluation

Bukavina, L.; Ginwala, R.; Sindhani, M.; Prunty, M.; Geynisman, D.; Pooja, G.; Valentine, H.; Calaway, A.; Brown, J. R.; Correa, A.; Mishra, K.; Pominville, R.; Plimack, E.; Kutikov, A.; Ghannoum, M.; ElShaer, M.; Retuerto, M.; Uzzo, R.; Ponsky, L.; Abbosh, P. H.

10.1101/2023.01.21.525021 — cancer biology — Posted on 2023-01-23

1230 A robust closed-tube method for resolving tp53M214K genotypes

Silvius, K. M.; Kendall, G. C.

10.1101/2023.01.20.524903 — cancer biology — Posted on 2023-01-23

1231 Self-inhibition of HER2 at fever temperatures may prevent dimerization with HER3

Singh, P. K.; Stan, R. C.

10.1101/2023.01.22.525115 — cancer biology — Posted on 2023-01-23

1232 Assessing HLA imputation accuracy in a West African population

Nanjala, R.; Mbiyavanga, M.; Hashim, S.; de Villiers, S.; Mulder, N.

10.1101/2023.01.23.525129 — bioinformatics — Posted on 2023-01-23

1233 Towards a reliable spatial analysis of missing features via spatially-regularized imputation

Qiao, C.; Huang, Y.

10.1101/2023.01.20.524992 — bioinformatics — Posted on 2023-01-23

1234 Serum albumin maintains Wnt water-solubility and activity

Yeo, J. H.; Kwon, S. S.; Chae, J.; Kusen, I.; Han, J.; Lim, J. Y.; Cheong, J.-H.; Kim, T. I.; Jung, Y. O.; Kim, C. H.; Lee, J.

10.1101/2023.01.22.525087 — biochemistry — Posted on 2023-01-23

1235 Calculation of Protein Folding Thermodynamics using Molecular Dynamics Simulations

Galano-Frutos, J. J.; Sancho, J.; Nerin-Fonz, F.

10.1101/2023.01.21.525008 — molecular biology — Posted on 2023-01-23

1236 Cytokines in the Urine of AKI patients regulate TP53 and SIRT1 and can be used as biomarkers for the early detection of AKI

Erichsen, L.; Thimm, C.; Wruck, W.; Kaierle, D.; Schless, M.; Huthmann, L.; Dimski, T.; Kindgen-Milles, D.; Brandenburger, T.; Adjaye, J.

10.1101/2023.01.20.524775 — molecular biology — Posted on 2023-01-23

1237 Selective bacteriophages reduce the emergence of resistant bacteria in the bacteriophage-antibiotic combination therapy

Azam, A. H.; Sato, K.; Miyanaga, K.; Nakamura, T.; Ojima, S.; Kondo, K.; Tamura, A.; Yamashita, W.; Tanji, Y.; Kiga, K.

10.1101/2023.01.22.525106 — microbiology — Posted on 2023-01-23

1238 Insm1 regulates the development of mTECs and immune tolerance

Tao, W.; Wei, Y.; Ye, Z.; Wang, J.; Yang, W.; Yu, G.; Xiong, J.; Jia, S.

10.1101/2023.01.14.524041 — immunology — Posted on 2023-01-23

1239 Chronic deep brain stimulation of the human nucleus accumbens region disrupts the stability of inter-temporal preferences.

Wagner, B. J.; Schueller, C. B.; Schueller, T.; Baldermann, J. C.; Kohl, S.; Visser-Vandewalle, V.; Huys, D.; Marx, M.; Kuhn, J.; Peters, J.

10.1101/2020.12.11.417337 — neuroscience — Posted on 2023-01-23

1240 Distinct spatial maps and multiple object codes in the lateral entorhinal cortex

Huang, X.; Schlesiger, M. I.; Barriuso-Ortega, I.; Leibold, C.; MacLaren, D. A. A.; Bieber, N.; Monyer, H.

10.1101/2022.12.19.521018 — neuroscience — Posted on 2023-01-23

1241 Experiential diversity training and science learning for college students alongside peers with intellectual and developmental disabilities

Rubenzer, K. N.; Pierce, J. T.

10.1101/2023.01.20.524901 — scientific communication and education — Posted on 2023-01-23

1242 Tetrameric UvrD helicase is located at the E. coli replisome due to frequent replication blocks

Wollman, A. J.; Syeda, A.; Howard, J.; Leech, A.; Guy, C.; McGlynn, P.; Hawkins, M.; Leake, M. C.

10.1101/2021.02.22.432310 — biophysics — Posted on 2023-01-23

1243 Transcriptome profiles of eggplant (Solanum melongena) and its wild relative S. dasyphyllum under different levels of osmotic stress provide insights into response mechanisms to drought

Villanueva, G.; Vilanova, S.; Plazas, M.; Prohens, J.; Gramazio, P.

10.1101/2022.11.02.514830 — genetics — Posted on 2023-01-23

1244 YTHDC2 serves a distinct late role in spermatocytes during germ cell differentiation

Bailey, A. S.; Fuller, M. T.

10.1101/2023.01.23.525146 — developmental biology — Posted on 2023-01-23

1245 Transcriptomic, proteomic and functional consequences of codon usage bias in human cells during heterologous gene expression.

Picard, M. A. L.; Leblay, F.; Cassan, C.; Willemsen, A.; Daron, J.; Bauffe, F.; Decourcelle, M.; Demange, A.; Bravo, I. G.

10.1101/2022.01.07.475042 — systems biology — Posted on 2023-01-23

1246 State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels

Park, Y. C.; Reddy, B.; Bavi, N.; Perozo, E.; Faraldo-Gomez, J. D.

10.1101/2022.07.01.498513 — biophysics — Posted on 2023-01-23

1247 Global analysis of aging-related protein structural changes uncovers enzyme polymerization-based control of longevity

Paukstyte, J.; Lopez Cabezas, R. M.; Feng, Y.; Tong, K.; Schnyder, D.; Elomaa, E.; Gregorova, P.; Doudin, M.; Sarkka, M.; Sarameri, J.; Lippi, A.; Vihinen, H.; Juutila, J.; Nieminen, A.; Toronen, P.; Holm, L.; Jokitalo, E.; Krisko, A.; Huiskonen, J. T.; Sarin, P.; Hietakangas, V.; Picotti, P.; Barral, Y.; Saarikangas, J.

10.1101/2023.01.23.524173 — cell biology — Posted on 2023-01-23

1248 Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma syndrome negatively regulates telomere length

Kliszczak, M.; Moralli, D.; Jankowska, J.; Bryjka, P.; Subha, L.; Goncalves, T.; Hester, S.; Fischer, R.; Clynes, D.; Green, C. M.

10.1101/2023.01.22.525054 — cell biology — Posted on 2023-01-23

1249 Sex differences in hippocampal cytokine networks after systemic immune challenge

Finnell, J. E.; Speirs, I. C.; Tronson, N. C.

10.1101/378257 — neuroscience — Posted on 2023-01-23

1250 The fate of recessive deleterious or overdominant mutations near mating-type loci under partial selfing

Tezenas, E.; Giraud, T.; Veber, A.; Billiard, S.

10.1101/2022.10.07.511119 — evolutionary biology — Posted on 2023-01-23

1251 Long-read direct RNA sequencing of the mitochondrial transcriptome of Saccharomyces cerevisiae reveals condition-dependent intron turnover

Koster, C. C.; Kleefeldt, A.; van den Broek, M.; Luttik, M.; Daran, J.-M. G.; Daran-Lapujade, P.

10.1101/2023.01.19.524680 — microbiology — Posted on 2023-01-23

1252 New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders

Pol Cros, M.; Mir-Pedrol, J.; Toloza, L.; Knoedlseder, N.; Guell, M.; Maroutti, J.; Zouboulis, C. C.; Fabrega, M. J.

10.1101/2022.12.15.520547 — immunology — Posted on 2023-01-23

1253 Resource allocation accounts for the large variabilityof rate-yield phenotypes across bacterial strains

Baldazzi, V.; Ropers, D.; Gouze, J.-L.; Gedeon, T.; de Jong, H.

10.1101/2022.04.27.489666 — systems biology — Posted on 2023-01-23

1254 Long-read whole genome analysis of human single cells

Hard, J.; Mold, J. E.; Eisfeldt, J.; Tellgren-Roth, C.; Häggqvist, S.; Bunikis, I.; Contreras-Lopez, O.; Chin, C.-S.; Nordlund, J.; Rubin, C.-J.; Feuk, L.; Michaëlsson, J.; Ameur, A.

10.1101/2021.04.13.439527 — genomics — Posted on 2023-01-23

1255 Surveillance of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Tan, C.; Trew, J.; Peacock, T. P.; Mok, K.; Hart, C.; Lau, K.; Ni, D.; Orme, D.; Ransome, E.; Pearse, W.; Coleman, C.; Bailey, D.; Thakur, N.; Quantrill, J.; Sukhova, K.; Richard, D.; Woodward, G.; Bell, T.; Worledge, L.; Nunez-Mino, J.; Barclay, W. S.; van Dorp, L.; Balloux, F.; Savolainen, V.

10.1101/2023.01.17.524183 — genomics — Posted on 2023-01-23

1256 Fractional Laser Treatment Boosts Systemic Anti-Tumor Immunity in Combination with OX40 Agonist and PD-1 Blockade

Kawakubo, M.; Glahn, J.; Tao, Z.; Demehri, S.; Manstein, D.

10.1101/2021.11.29.470433 — immunology — Posted on 2023-01-23

1257 Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen

Chen, G. Y.; Thorup, N. R.; Miller, A. J.; Li, Y.-C.; Ayres, J. S.

10.1101/2023.01.22.525099 — immunology — Posted on 2023-01-22

1258 Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress

Melnick, A.; Liang, S.; Liu, Y.; Wang, Q.; Dean, N.; Choe, E.; Kunnath, N.; Bodanapu, G.; Mullin, C.; Akter, F.; Lin, K.; Magnuson, B.; Kumar, S.; Lombard, D. B.; Muntean, A. G.; Ljungman, M.; Sekiguchi, J.; Ryan, R. J. H.; Chiang, M. Y.

10.1101/2023.01.22.525059 — cancer biology — Posted on 2023-01-22

1259 Sustained release Resolvin D1 liposomes are effective in the treatment of osteoarthritis in obese mice

Dravid, A. A.; Dhanabalan, K. M.; Naskar, S.; Vashistha, A.; Agarwal, S.; Padhan, B.; Dewani, M.; Agarwal, R.

10.1101/2023.01.21.525015 — bioengineering — Posted on 2023-01-22

1260 RNA Polymerase II, the BAF remodeler and transcription factors synergize to evict nucleosomes

Brahma, S.; Henikoff, S.

10.1101/2023.01.22.525083 — genomics — Posted on 2023-01-22

1261 Sensitized piRNA reporter identifies multiple RNA processing factors involved in piRNA-mediated gene silencing

Brown, J. S.; Zhang, D.; Chen, W.; Lee, H.-C.

10.1101/2023.01.22.525052 — genetics — Posted on 2023-01-22

1262 Modeling of African population history using f-statistics can be highly biased and is not addressed by previously suggested SNP ascertainment schemes

Flegontov, P.; Isıldak, U.; Maier, R.; Yüncü, E.; Changmai, P.; Reich, D.

10.1101/2023.01.22.525077 — genetics — Posted on 2023-01-22

1263 Gliding towards an understanding of the origin of flight in bats

Burtner, A. E.; Grossnickle, D. M.; Santana, S. E.; Law, C. J.

10.1101/2022.09.26.509622 — evolutionary biology — Posted on 2023-01-22

1264 Human Cryptochrome1 dampens homologous recombination at nightfall

Romero-Franco, A.; Checa-Rodriguez, C.; Castellano-Pozo, M.; Miras, H.; Wals, A.; Huertas, P.

10.1101/2023.01.22.524239 — cell biology — Posted on 2023-01-22

1265 S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

Godbole, A. A.; Gopalan, S.; Nguyen, T.-K.; Munden, A. L.; Vo, P.; Lewis, C. A.; Spinelli, J. B.; Fazzio, T. G.; Walker, A. K.

10.1101/2022.03.30.486419 — cell biology — Posted on 2023-01-22

1266 Two residues determine nicotinic acetylcholine receptor requirement for RIC-3

Noonan, J. D.; Beech, R.

10.1101/2023.01.22.525060 — molecular biology — Posted on 2023-01-22

1267 Microbial fingerprints reveal interaction between museum objects, curators and visitors

Simon, L.; Flocco, C.; Henke, D. M.; Rauer, L.; Müller, C.; Vogel, J.; Quassier, C.; Overmann, J.; Simon, S.

10.1101/2023.01.04.522779 — microbiology — Posted on 2023-01-22

1268 Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

Marichannegowda, M. H.; Zemil, M.; Wieczorek, L.; Sanders-Buell, E.; Bose, M.; O'Sullivan, A. M.; King, D.; Francisco, L.; Diaz-Mendez, F.; Setua, S.; Chomont, N.; Phanuphak, N.; Ananworanich, J.; Hsu, D.; Vasan, S.; Michael, N. L.; Eller, L. A.; Tovanabutra, S.; Tagaya, Y.; Robb, M. L.; Polonis, V. R.; Song, H.

10.1101/2023.01.21.525033 — microbiology — Posted on 2023-01-22

1269 MEK1/2 inhibition decreases pro-inflammatory responses in macrophages from people with cystic fibrosis and mitigates severity of illness in experimental murine methicillin-resistant Staphylococcus aureus infection

De, M.; Hisert, K. B.; Liles, W. C.; Manicone, A. M.; Hemann, E. A.; Long, M. E.

10.1101/2023.01.22.525092 — immunology — Posted on 2023-01-22

1270 Targeted Anatomical and Functional Identification of Antinociceptive and Pronociceptive Serotonergic Neurons that project to the Superficial Dorsal Horn

Ganley, R. P.; Sousa, M.; Werder, K.; Öztürk, T.; Mendes, R.; Ranucci, M.; Wildner, H.; Zeilhofer, H. U.

10.1101/2022.03.15.484537 — neuroscience — Posted on 2023-01-22

1271 Common rules underlying optogenetic and behavioral modulation of responses in multi-cell-type V1 circuits

Palmigiano, A.; Fumarola, F.; Mossing, D. P.; Kraynyukova, N.; Adesnik, H.; Miller, K.

10.1101/2020.11.11.378729 — neuroscience — Posted on 2023-01-22

1272 Novel genetic modules encoding high-level antibiotic-free protein expression in probiotic lactobacilli

Dey, S.; Blanch Asensio, M.; Balaji Kuttae, S.; Sankaran, S.

10.1101/2022.08.04.502766 — synthetic biology — Posted on 2023-01-22

1273 Selective sweeps identification in distinct groups of cultivated rye (Secale cereale L.) germplasm provides potential candidates for crop improvement

Hawliczek, A.; Borzecka, E.; Tofil, K.; Alachiotis, N.; Bolibok, L.; Gawronski, P.; Siekmann, D.; Hackauf, B.; Dusinsky, R.; Svec, M.; Bolibok-Bragoszewska, H.

10.1101/2023.01.22.525081 — plant biology — Posted on 2023-01-22

1274 Reproducible growth of Brachypodium distachyon in fabricated ecosystems (EcoFAB 2.0) reveals that nitrogen form and starvation modulate root exudation

Novak, V.; Andeer, P. F.; Bowen, B. P.; Ding, Y.; Zhalnina, K.; Tomaka, C.; Golini, A.; Kosina, S. M.; Northen, T. R.

10.1101/2023.01.18.524647 — plant biology — Posted on 2023-01-22

1275 Establishment of cell transcriptional identity during seed germination

Liew, L. C.; You, Y.; Oliva, M.; Peirats-Llobet, M.; Ng, S.; Tamiru-Oli, M.; Berkowitz, O. G.; Hong, U. V. T.; Haslem, A.; Stuart, T.; Ritchie, M. E.; Bassel, G.; Lister, R.; Whelan, J.; Gouil, Q.; Lewsey, M. G.

10.1101/2023.01.21.523180 — plant biology — Posted on 2023-01-22

1276 Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Mumphrey, M. B.; Hosseini, N.; Parolia, A.; Geng, J.; Zou, W.; Raghavan, M.; Chinnaiyan, A.; Cieslik, M.

10.1101/2023.01.22.523447 — cancer biology — Posted on 2023-01-22

1277 Gemini: Memory-efficient integration of hundreds of gene networks with high-order pooling

Woicik, A.; Zhang, M.; Xu, H.; Mostafavi, S.; Wang, S.

10.1101/2023.01.21.525026 — bioinformatics — Posted on 2023-01-22

1278 Integrating disease genetics and drug bioassays to discover drug impacts on the human phenome

Habib, M.; Melamed, R. D.

10.1101/2023.01.22.525094 — bioinformatics — Posted on 2023-01-22

1279 Development and qualification of a high-yield recombinant human Erythropoietin biosimilar

Nag, K.; Islam, M. J.; Khan, M. M. R.; Rahman Chowdhury, M. M.; Haq Sarker, M. E.; Kumar, S.; Khan, H.; Chakraborty, S.; Roy, R.; Roy, R.; Oli, M. S. K.; Barman, U.; Bappi, M. E. H.; Biswas, B. K.; Mohiuddin, M.; Sultana, N.

10.1101/2023.01.22.525046 — bioengineering — Posted on 2023-01-22

1280 Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome

Yan, T.; Julio, A. R.; Villanueva, M.; Jones, A. E.; Ball, A. B.; Boatner, L. M.; Turmon, A. C.; Yen, S. L.; Desai, H. S.; Divakaruni, A. S.; Backus, K. M.

10.1101/2023.01.22.525042 — biochemistry — Posted on 2023-01-22

1281 A genomic panel for studying C3-C4 intermediate photosynthesis in the Brassiceae tribe

Guerreiro, R. F.; Bonthala, V. S.; Schluter, U.; Triesch, S.; Weber, A. P. M.; Stich, B.

10.1101/2023.01.22.525068 — genomics — Posted on 2023-01-22

1282 A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens

Guna, A.; Page, K. R.; Replogle, J. R.; Esantsi, T. K.; Wang, M. L.; Weissman, J. S.; Voorhees, R. M.

10.1101/2023.01.22.525086 — genomics — Posted on 2023-01-22

1283 Evolution during uncorrelated environmental fluctuations: bet-hedging or phenotypic plasticity?

Sekajova, Z.; Fossen, E. I. F.; Rosa, E.; Ratikainen, I. I.; Tourniaire-Blum, M.; Bolund, E.; Lind, M. I.

10.1101/2023.01.22.523389 — evolutionary biology — Posted on 2023-01-22

1284 Nano-computed tomography reveals repeated phenotypic divergence in parasites to escape host defense

Kolencik, S.; Stanley, E. L.; Punnath, A.; Grant, A. R.; Dona, J.; Johnson, K. P.; Allen, J. M.

10.1101/2023.01.21.525028 — evolutionary biology — Posted on 2023-01-22

1285 Fungal zoospores show contrasting swimming patterns specific to phylum and cytology

Galindo, L. J.; Richards, T. A.; Nirody, J. A.

10.1101/2023.01.22.525074 — evolutionary biology — Posted on 2023-01-22

1286 Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs

Aube, S.; Nielly-Thibault, L.; Landry, C. R.

10.1101/2022.05.24.493236 — evolutionary biology — Posted on 2023-01-22

1287 Structure and stability constrained substitution models outperform traditional substitution models used for evolutionary inference

Lorca, I.; Arenas, M.; Bastolla, U.

10.1101/2023.01.22.525075 — evolutionary biology — Posted on 2023-01-22

1288 Human scalp hair as a thermoregulatory adaptation

Lasisi, T.; Smallcombe, J. W.; Kenney, W. L.; Shriver, M. D.; Zydney, B.; Jablonski, N. G.; Havenith, G.

10.1101/2023.01.21.524663 — evolutionary biology — Posted on 2023-01-22

1289 Identifying drivers of sewage-associated pollutants in pollinators across urban landscapes

Meyer, M. F.; Brousil, M. R.; Lee, B. W.; Armstrong, M. L.; Bloom, E. H.; Crowder, D. W.

10.1101/2023.01.20.524979 — ecology — Posted on 2023-01-22

1290 Breakdown in seasonal dynamics of ant communities with land-cover change

Kass, J. M.; Yoshimura, M.; Ogasawara, M.; Suwabe, M.; Hita Garcia, F.; Fischer, G.; Dudley, K. L.; Donohue, I.; Economo, E. P.

10.1101/2023.01.17.523860 — ecology — Posted on 2023-01-22

1291 Mitochondrial citrate metabolism and efflux regulates trophoblast differentiation

Mahr, R. M.; Jena, S.; Nashif, S. K.; Nelson, A. B.; Rauckhorst, A. J.; Rome, F. I.; Sheldon, R. D.; Hughey, C. C.; Puchalska, P.; Gearhart, M. D.; Taylor, E. B.; Crawford, P. A.; Wernimont, S. A.

10.1101/2023.01.22.525071 — developmental biology — Posted on 2023-01-22

1292 Aurora B Kinase Dependent Phosphorylation of Keratin 8 is required for Cytokinesis in Mammalian Cells of Epithelial Origin

Harmanda, B.; Kaya, O.; Waide, X.; Qureshi, M. H.; Nesvizhskii, A.; Mitchison, T.; Ozlu, N.

10.1101/2023.01.22.525045 — cell biology — Posted on 2023-01-22

1293 BiFCo: Visualising cohesin assembly/disassembly cycle in living cells.

Gonzalez-Martin, E.; Jimenez, J.; A. Tallada, V.

10.1101/2023.01.21.525018 — cell biology — Posted on 2023-01-22

1294 Hep3D: A 3D single-cell digital atlas of the liver to study spatio-temporal tissue architecture

Martinez, D.; Maldonado, V.; Perez, C.; Yanez, R.; Candia, V.; Kalaidzidis, Y.; Zerial, M.; Morales-Navarrete, H.; Segovia-Miranda, F.

10.1101/2023.01.21.525037 — cell biology — Posted on 2023-01-22

1295 The modular biochemical reaction network structure of cellular translation

Zuviria, B. C.; Fer, E.; Adam, Z. R.; Kacar, B.

10.1101/2023.01.21.524914 — molecular biology — Posted on 2023-01-22

1296 Single-cell and spatial multi-omics identify innate and stromal modules targeted by anti-integrin therapy in ulcerative colitis.

Mennillo, E.; Kim, Y. J.; Rusu, I.; Lee, G.; Dorman, L. C.; Bernard-Vazquez, F.; Bain, J. L.; Patel, R.; Andersen, C.; Rao, A.; Tamaki, S.; Tsui, J.; Shen, A.; Naser, M.; Eckalbar, W.; Cho, S.-j.; Beck, K.; El-Nachef, N.; Lewin, S.; Selvig, D. R.; Terdiman, J. P.; Mahadevan, U.; Oh, D.; Fragiadakis, G. K.; Pisco, A.; Combes, A.; Kattah, M. G.

10.1101/2023.01.21.525036 — immunology — Posted on 2023-01-22

1297 Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion

De Munter, S.; Buhl, J.; De Cock, L.; Van Parys, A.; Daneels, W.; Pascal, E.; Deseins, L.; Ingels, J.; Goetgeluk, G.; Billiet, L.; Pille, M.; Vandamme, N.; Van Dorpe, J.; Offner, F.; Depla, E.; Tavernier, J.; Kerre, T.; Drost, J.; Vandekerckhove, B.

10.1101/2023.01.22.523482 — immunology — Posted on 2023-01-22

1298 Covariance-based decoding reveals content-specific feature integration and top-down processing during visual imagery

Mantegna, F.; Olivetti, E.; Schwedhelm, P.; Baldauf, D.

10.1101/2022.09.26.509536 — neuroscience — Posted on 2023-01-22

1299 Linking genetic and environmental factors through marker effect networks to understand trait plasticity

Della Coletta, R.; Liese, S. E.; Fernandes, S. B.; Mikel, M. A.; Bohn, M. O.; Lipka, A. E.; Hirsch, C. N.

10.1101/2023.01.19.524532 — plant biology — Posted on 2023-01-22

1300 Androgen aggravates aortic aneurysms via suppressing PD-1 in mice

Mu, X.; Liu, S.; Wang, Z.; Jiang, K.; McClintock, T. S.; Stromberg, A.; Villasante-Tezanos, A.; Lee, E. S.; Curci, J. A.; Gong, M. C.; Guo, Z.

10.1101/2023.01.22.525073 — pathology — Posted on 2023-01-22

1301 Intracellular conformation of amyotrophic lateral sclerosis-causative TDP-43

Kitamura, A.; Yuno, S.; Kawamura, R.; Kinjo, M.

10.1101/2023.01.22.525050 — biophysics — Posted on 2023-01-22

1302 Structural Determinants of Redox Conduction Favor Robustness over Tunability in Microbial Cytochrome Nanowires

Guberman-Pfeffer, M. J.

10.1101/2023.01.21.525004 — biophysics — Posted on 2023-01-22

1303 Blind Assessment of Monomeric AlphaFold2 Protein Structure Models with Experimental NMR Data

Li, E.; Spaman, L.; Tejero, R.; Huang, Y. J.; Ramelot, T. A.; Fraga, K.; Prestegard, J. H.; Kennedy, M. A.; Montelione, G. T.

10.1101/2023.01.22.525096 — bioinformatics — Posted on 2023-01-22

1304 PC_sim: An integrated measure of protein sequence and structure similarity for improved alignments and evolutionary inference

Piette, O.; Abia, D.; Bastolla, U.

10.1101/2023.01.22.525078 — bioinformatics — Posted on 2023-01-22

1305 Spectroscopic insights into the mechanism of anammox hydrazine synthase

Versantvoort, W.; Hienerwadel, R.; Ferousi, C.; van der Velden, P.; Berthomieu, C.; van Niftrik, L.; Baymann, F.

10.1101/2023.01.22.525020 — biochemistry — Posted on 2023-01-22

1306 Mitochondrial diabetes in mice expressing a dominant-negative allele of nuclear respiratory factor-1 (NRF-1) in pancreatic and β-cells

Morrish, F.; Sweet, I. R.; Hockenbery, D. M.

10.1101/2023.01.22.524153 — molecular biology — Posted on 2023-01-22

1307 Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting

10.1101/2023.01.21.525033 — microbiology — Posted on 2023-01-22

1308 Capturing the dynamics of microbiomes using individual-specific networks

Yousefi, B.; Melograna, F.; Galazzo, G.; van Best, N.; Mommers, M.; Penders, J.; Schwikowski, B.; van Steen, K.

10.1101/2023.01.22.525058 — microbiology — Posted on 2023-01-22

1309 Empirically identifying and computationally modelling the brain-behaviour relationship for human scene categorization

Karapetian, A.; Boyanova, A.; Pandaram, M.; Obermayer, K.; Kietzmann, T. C.; Cichy, R. M.

10.1101/2023.01.22.525084 — neuroscience — Posted on 2023-01-22

1310 Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity

Harris, N.; Bates, S.; Zhuang, Z.; Bernstein, M.; Stonemetz, J.; Hill, T.; Yu, Y. V.; Calarco, J. A.; Sengupta, P.

10.1101/2023.01.22.525070 — neuroscience — Posted on 2023-01-22

1311 Mental image reconstruction from human brain activity

Koide-Majima, N.; Majima, K.

10.1101/2023.01.22.525062 — neuroscience — Posted on 2023-01-22

1312 Attention to Colour: Spotlight in Hue Space

Martinovic, J.; Boyanova, A.; Andersen, S. K.

10.1101/2023.01.22.525095 — neuroscience — Posted on 2023-01-22

1313 Oomycete effector AVRblb2 targets cyclic nucleotide-gated channels through calcium sensors to suppress pattern-triggered immunity

Lee, S.; Lee, J. H.; Lee, H.-Y.; Kang, H. J.; Seo, Y.-E.; Choi, D.

10.1101/2023.01.18.524664 — plant biology — Posted on 2023-01-22

1314 Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein

Bosnakovski, D.; Toso, E. A.; Ener, E. T.; Gearhart, M. D. D.; Yin, L.; Luettmann, F. F.; Magli, A.; Shi, K.; Kim, J.; Aihara, H.; Kyba, M.

10.1101/2023.01.21.524976 — molecular biology — Posted on 2023-01-22

1315 A cathepsin C-like protease post-translationally modifies Toxoplasma gondii secretory proteins for optimal invasion and egress.

Thornton, L. B.; Key, M.; Micchelli, C.; Stasic, A. J.; Kwain, S.; Floyd, K.; Moreno, S. N. J.; Dominy, B. N.; Whitehead, D. C.; Dou, Z.

10.1101/2023.01.21.525043 — microbiology — Posted on 2023-01-22

1316 Representation and Retrieval of Brain Connectivity Information derived from TMS Experiments

Wittenberg, G. F.; Fang, X.; Roy, S.; Lee, B.; Miskov-Zivanov, N. F.; Hochheiser, H.; Banihashemi, L.; Vesia, M.; Ramsey, J.

10.1101/2023.01.22.522249 — neuroscience — Posted on 2023-01-22

1317 Distinct neural components of visually guided grasping during planning and execution

Klein, L. K.; Maiello, G.; Stubbs, K. M.; Proklova, D.; Chen, J.; Paulun, V. C.; Culham, J. C.; Fleming, R. W.

10.1101/2023.01.22.525053 — neuroscience — Posted on 2023-01-22

1318 End-to-End Explainable AI: Derived Theory-of-Mind Fingerprints to Distinguish Between Autistic and Typically developing and Social Symptom Severity

Bhavna, K.; Banerjee, R.; Roy, D.

10.1101/2023.01.21.525016 — neuroscience — Posted on 2023-01-22

1319 Supporting central nervous system neuroprotection and remyelination by specific TLR4 antagonism

Fernandez-Gomez, B.; Marchena, M. A.; Pineiro, D.; Lao, Y.; Valencia, G.; Nocera, S.; Benitez-Fernandez, R.; Gomez-Martin, P.; Castano-Leon, A. M.; Lagares, A.; Hernandez-Jimenez, M.; de Castro, F.

10.1101/2023.01.22.524916 — neuroscience — Posted on 2023-01-22

1320 Sex, but not early life stress, effects on two-bottle choice alcohol drinking behaviors in mice

Perry, T. W.; Sneddon, E. A.; Reichert, A. N.; Schuh, K. M.; Shand, N. A.; Quinn, J. J.; Radke, A. K.

10.1101/2023.01.21.524642 — neuroscience — Posted on 2023-01-22

1321 Sex differences in adolescent cannabis vapor self-administration mediate enduring effects on behavioral flexibility and prefrontal microglia activation in rats

Freels, T. G.; Westbrook, S. R.; Wright, H. R.; Kuyat, J. R.; Zamberletti, E.; Malena, A. N.; Melville, M. W.; Brown, A. M.; Glodosky, N. C.; Ginder, D. E.; Klappenbach, C. M.; Delevich, K. M.; Rubino, T.; McLaughlin, R. J.

10.1101/2023.01.21.524468 — neuroscience — Posted on 2023-01-22

1322 Cortical Representation of Movement Across the Developmental Transition to Continuous Neural Activity

Glanz, R. M.; Sokoloff, G.; Blumberg, M. S.

10.1101/2023.01.22.525085 — neuroscience — Posted on 2023-01-22

1323 Trial-history biases in evidence accumulation can give rise to apparent lapses

Gupta, D.; DePasquale, B.; Kopec, C. D.; Brody, C. D.

10.1101/2023.01.18.524599 — animal behavior and cognition — Posted on 2023-01-22

1324 Surveillance of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

10.1101/2023.01.17.524183 — genomics — Posted on 2023-01-22

1325 High genetic diversity and blaNDM-1 prevalence among Acinetobacter baumannii in Nigerian hospitals

Odih, E. E.; Oaikhena, A. O.; Underwood, A.; Hounmanou, Y. M. G.; Oduyebo, O.; Fadeyi, A.; Aboderin, O.; Ogunleye, V. O.; Argimon, S.; Akpunonu, V. N.; Oshun, P. O.; Egwuenu, A.; Okwor, T. J.; Ihekweazu, C.; Aanensen, D. M.; Dalsgaard, A.; Okeke, I. N.

10.1101/2023.01.20.524999 — genomics — Posted on 2023-01-22

1326 Adult-specific Reelin expression alters striatal neuronal organization. Implications for neuropsychiatric disorders.

Pardo, M.; Gregorio, S.; Montalban, E.; Pujadas, L.; Elias-Tersa, A.; Masachs, N.; Vilchez-Acosta, A.; Parent, A.; Auladell, C.; Girault, J. A.; Vila, M.; Nairn, A. C.; Manso, Y.; Soriano, E.

10.1101/2023.01.21.525025 — neuroscience — Posted on 2023-01-22

1327 Sexual deprivation modulates social interaction and reproductive physiology

Shohat-Ophir, G.

10.1101/2021.04.27.441612 — animal behavior and cognition — Posted on 2023-01-22

1328 Allelic Transcription Factor binding shape transcriptional kinetics observed with scRNA-seq in human cell lines

Jin, B.; Feng, H.; Bush, W.

10.1101/2022.09.21.508743 — genetics — Posted on 2023-01-21

1329 Parental care maintains genetic variation by relaxing selection

Pascoal, S.; Shimadzu, H.; Mashoodh, R.; Kilner, R.

10.1101/2022.05.05.490718 — evolutionary biology — Posted on 2023-01-21

1330 LXR-inducible host E3 ligase IDOL targets a human cytomegalovirus reactivation determinant to promote latency

Mlera, L.; Collins-McMillen, D. K.; Zeltzer, S.; Buehler, J.; Moy, M.; Zarrella, K.; Caviness, K.; Cicchini, L.; Tafoya, D. J.; Goodrum, F.

10.1101/2022.11.15.516687 — microbiology — Posted on 2023-01-21

1331 Use of CD122+ natural killer cell precursors for superior anti-leukemia responses.

Guglietta, S.; Cardenas, L.; Krieg, C.

10.1101/2022.10.24.513585 — immunology — Posted on 2023-01-21

1332 The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cells.

McClatchy, J.; Strogantsev, R.; Wolfe, E.; Lin, H.-Y.; Mohammadhosseini, M.; Davis, B.; Eden, C.; Goldman, D.; Fleming, W.; Conley, P.; Wu, G.; Cimmino, L.; Mohammed, H.; Agarwal, A.

10.1101/2022.09.15.507688 — cancer biology — Posted on 2023-01-21

1333 Complete sequence verification of plasmid DNA using the Oxford Nanopore Technologies' MinION device

Brown, S. D.; Dreolini, L.; Wilson, J. F.; Balasundaram, M.; Holt, R. A.

10.1101/2022.06.21.497051 — bioinformatics — Posted on 2023-01-21

1334 MacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes

Neron, B.; Denise, R.; Coluzzi, C.; Touchon, M.; Rocha, E. P. C.; Abby, S. S.

10.1101/2022.09.02.506364 — bioinformatics — Posted on 2023-01-21

1335 Developing a robust technique for denoising and extracting speech and breath sounds in voice recordings from asthmatic patients

Sayed, S. F.; I. Rezwan, F.

10.1101/2023.01.20.524994 — bioinformatics — Posted on 2023-01-21

1336 Teasing out Missing Reactions in Genome-scale Metabolic Networks through Graph Convolutional Networks

Chen, C.; Liao, C.; Liu, Y.-Y.

10.1101/2022.06.27.497720 — bioinformatics — Posted on 2023-01-21

1337 Reprogramming of the cardiac phosphoproteome in conjunction with proteome and transcriptome creates the enhanced performance and protection circuitry in response to chronic adenylyl cyclase-driven stress

Qu, J.-H.; Chakir, K.; Tarasov, K. V.; Riordon, D. R.; Perino, M. G.; Silvester, A. J.; Lakatta, E. G.

10.1101/2022.04.29.488779 — bioinformatics — Posted on 2023-01-21

1338 Nonlinear Parameter and State Estimation Approach in End-stage Kidney Disease Patients

Abohtyra, R.; Vincent, T. L.

10.1101/2022.04.02.486844 — bioengineering — Posted on 2023-01-21

1339 Evidence for cryptic gene flow in parthenogenetic stick insects of the genus Timema

Freitas, S. N. d.; Parker, D. J.; Labedan, M.; Dumas, Z.; Schwander, T.

10.1101/2023.01.21.525009 — evolutionary biology — Posted on 2023-01-21

1340 Evolutionarily diverse origins of honey bee deformed wing viruses

Hasegawa, N.; Techer, M.; al-Hissnawi, M.; Adjlane, N.; Antunez, K.; Beaurepaire, A.; Christmon, K.; Delatte, H.; Dukku, U.; Eliash, N.; El-Niweir, M.; Esnault, O.; Evans, J.; Haddad, N.; Locke, B.; Munoz, I.; Noel, G.; Panziera, D.; Roberts, J.; De la Rua, P.; Shebl, M.; Stanimirovic, Z.; Rasmussen, D.; Mikheyev, A.

10.1101/2023.01.21.525007 — evolutionary biology — Posted on 2023-01-21

1341 Geodesics to characterize the phylogenetic landscape

Khodaei, M.; Owen, M.; Beerli, P.

10.1101/2022.05.11.491507 — evolutionary biology — Posted on 2023-01-21

1342 ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS

Magri, A.; Lipari, C. L. R.; Risiglione, P.; Zimbone, S.; Guarino, F.; Caccamo, A.; Messina, A.

10.1101/2023.01.21.524879 — neuroscience — Posted on 2023-01-21

1343 Asymmetric retinal direction tuning predicts optokinetic eye movements across stimulus conditions

Harris, S. C.; Dunn, F. A.

10.1101/2022.06.10.495717 — neuroscience — Posted on 2023-01-21

1344 Effect of LSD and music on the time-varying brain dynamics

Adamska, I.; Finc, K.

10.1101/2022.04.04.486673 — neuroscience — Posted on 2023-01-21

1345 Glycoprotein-glycoprotein receptor binding detection using bioluminescence resonance energy transfer (BRET)

Adamczuk, K.; Rivero-Muller, A.

10.1101/2023.01.21.525003 — physiology — Posted on 2023-01-21

1346 The dynamics of whole blood and blood cells during a routine clinical laboratory test

Taye, M.

10.1101/2023.01.21.525013 — biophysics — Posted on 2023-01-21

1347 VRPG: an interactive web viewer for reference pangenome graphs

Miao, Z.; Yue, J.-X.

10.1101/2023.01.20.524991 — bioinformatics — Posted on 2023-01-21

1348 Texture-Based Image Analysis For the Assessment of Soybeans

Lee, A.; Hoffseth, K.

10.1101/2023.01.20.524975 — bioengineering — Posted on 2023-01-21

1349 Effects of phylogenetic variation on prioritization of species for conservation

Wicke, K.; Haque, M. R.; Kubatko, L.

10.1101/2023.01.21.525012 — evolutionary biology — Posted on 2023-01-21

1350 Improving genome quality through artificial truncating purifying selection using heat shock: case of carps

10.1101/2023.01.20.524958 — evolutionary biology — Posted on 2023-01-21

1351 Mitochondrial Genome Analysis and Phylogeny and Divergence Time Evaluation of the Strix aluco

Wang, Y.; Zhan, H.; Yang, X.; Zhang, Y.; Long, Z.; Li, B.; Lv, X.; Wildlife Rescue Center of Leigong Mountain National Nature Reserve,

10.1101/2023.01.20.524943 — evolutionary biology — Posted on 2023-01-21

1352 Decomposing intraspecific phenotypic variation: implications for species and functional diversity

Worthy, S. J.; Umana, M. N.; Zhang, C.; Lin, L.; Cao, M.; Swenson, N. G.

10.1101/2023.01.20.524990 — ecology — Posted on 2023-01-21

1353 Broadly Neutralizing Antibody Epitopes on HIV-1 Particles are exposed after Virus Interaction with Host Cells

Rao, P. G.; Lambert, G. S.; Upadhyay, C.

10.1101/2023.01.20.524996 — microbiology — Posted on 2023-01-21

1354 Pyricularia Populations are Mostly Host-Specialized with Limited Reciprocal Cross-Infection Between Wheat and Endemic Grasses in Minas Gerais, Brazil

Ascari, J. P.; Cazon, L. I.; Rahnama, M.; Lamour, K.; Fernandes, J. M. C.; Farman, M. L.; Del Ponte, E. M.

10.1101/2023.01.20.524950 — microbiology — Posted on 2023-01-21

1355 A HicA toxin-based counter-selection marker for allelic exchange mutations in Fusobacterium nucleatum

Wu, C.; GC, B.; Zhou, P.

10.1101/2023.01.20.524997 — microbiology — Posted on 2023-01-21

1356 Hippocampal subfield volumes contribute to working memory interference control in aging: Evidence from longitudinal associations over 5 years

Andersson, P.; Samrani, G.; Andersson, M.; Persson, J.

10.1101/2023.01.21.525011 — neuroscience — Posted on 2023-01-21

1357 A vocalization-processing network in marmosets

Jafari, A.; Dureux, A.; Zanini, A.; Menon, R. S.; Gilbert, K. M.; Everling, S.

10.1101/2023.01.20.524963 — neuroscience — Posted on 2023-01-21

1358 Is there a brain area dedicated to socially guided spatial attention?

Gorner, M.; Dicke, P. W.; Thier, P.

10.1101/2023.01.20.524674 — neuroscience — Posted on 2023-01-21

1359 Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension

Ulbrich, P.; Morton, L.; Briese, M.; Laemmlin, N.; Mattern, H.; Hasanuzzaman, M.; Westhues, M.; Khoshneviszadeh, M.; Appenzeller, S.; Guendel, D.; Toussaint, M.; Brust, P.; Kniess, T.; Oelschlegel, A.; Goldschmidt, J.; Meuth, S.; Heinze, H. J.; Vielhaber, G. D.; Vielhaber, S.; Becker, A.; Dityatev, A.; Jandke, S.; Sendtner, M.; Dunay, I.; Schreiber, S.

10.1101/2023.01.20.524921 — neuroscience — Posted on 2023-01-21

1360 Intercellular extrachromosomal DNA copy number heterogeneity drives cancer cell state diversity

Stoeber, M. C.; Chamorro Gonzalez, R.; Brueckner, L.; Conrad, T.; Wittstruck, N.; Szymansky, A.; Eggert, A.; Schulte, J. H.; Koche, R. P.; Henssen, A. G.; Schwarz, R. F.; Haase, K.

10.1101/2023.01.21.525014 — cancer biology — Posted on 2023-01-21

1361 Intergenerational scaling law determines the precision kinematics of stochastic individual-cell-size homeostasis

Joshi, K.; Biswas, R. R.; Iyer-Biswas, S.

10.1101/2023.01.20.525000 — biophysics — Posted on 2023-01-21

1362 Rational positioning of 3D printed micro-bricks to realize high-fidelity, multi-functional soft-hard interfaces

Saldivar, M. C.; Salehi, S.; Veeger, R. P. E.; Fenu, M.; Cantamessa, A.; Klimopoulou, M.; Talo, G.; Moretti, M.; Lopa, S.; Ruffoni, D.; Osch, G. v.; Fratila-Apachitei, L. E.; Doubrovski, E. L.; Mirzaali, M. J.; Zadpoor, A. A.

10.1101/2023.01.21.525002 — bioengineering — Posted on 2023-01-21

1363 Towards Reduced Order Models via Robust Proper Orthogonal Decomposition to Capture Personalised Aortic Haemodynamics

Chatpattanasiri, C.; Franzetti, G.; Bonfanti, M.; Diaz-Zuccarini, V.; Balabani, S.

10.1101/2023.01.21.524933 — bioengineering — Posted on 2023-01-21

1364 Inconsistent estimates of hybridization frequency in newts revealed by SNPs and microsatellites

Miralles, A.; Secondi, J.; Pabijan, M.; Babik, W.; Lemaire, C.; Crochet, P.-A.

10.1101/2023.01.21.525005 — genetics — Posted on 2023-01-21

1365 Population genomic analysis of an emerging pathogen Lonsdalea quercina affecting various species of oaks in western North America

Kozhar, O.; Sitz, R. A.; Woyda, R.; Legg, L.; Ibarra Caballero, J. R.; Pearse, I.; Abdo, Z.; Stewart, J. E.

10.1101/2023.01.20.524998 — evolutionary biology — Posted on 2023-01-21

1366 A high-performance speech neuroprosthesis

Willett, F. R.; Kunz, E.; Fan, C.; Avansino, D.; Wilson, G.; Choi, E. Y.; Kamdar, F.; Hochberg, L. R. H.; Druckmann, S.; Shenoy, K.; Henderson, J.

10.1101/2023.01.21.524489 — neuroscience — Posted on 2023-01-21

1367 Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex

Witteveen, I.; McCoy, E.; Holsworth, T.; Shen, C.; Chang, W.; Nance, M.; Belkowitz, A.; Douglad, A.; Puglia, M.; Ribic, A.

10.1101/2023.01.20.524993 — neuroscience — Posted on 2023-01-21

1368 Variable effects of Wolbachia on alphavirus infection in Aedes aegypti

Dodson, B. L.; Pujhari, S.; Brustolin, M. L.; Metz, H. C.; Rasgon, J. L.

10.1101/2023.01.20.524939 — microbiology — Posted on 2023-01-21

1369 Netrin-1 binding to Unc5B regulates Blood-Retina Barrier integrity

Furtado, J.; Geraldo, L. H.; Leser, F. S.; Poulet, M.; Park, H.; Pibouin-Fragner, L.; Eichmann, A.; Boye, K.

10.1101/2023.01.21.525006 — cell biology — Posted on 2023-01-21

1370 Lipopolysaccharide integrity primes bacterial sensitivity to a cell wall-degrading intermicrobial toxin

Trotta, K. L.; Hayes, B.; Schneider, J. P.; Wang, J.; Todor, H.; Grimes, P. R.; Zhao, Z.; Hatleberg, W.; Silvis, M.; Kim, R.; Koo, B.-M.; Basler, M.; Chou, S.

10.1101/2023.01.20.524922 — microbiology — Posted on 2023-01-21

1371 Optimizing FreeSurfer's Surface Reconstruction Parameters for Anatomical Feature Estimation

Baratz, Z.; Assaf, Y.

10.1101/2023.01.02.522457 — neuroscience — Posted on 2023-01-21

1372 Gene networks driven by genetic variation for plasma cortisol in hepatic and adipose tissues implicate corticosteroid binding globulin in modulating tissue glucocorticoid action and cardiovascular risk

Bankier, S.; Wang, L.; Crawford, A.; Morgan, R. A.; Ruusalepp, A.; Andrew, R.; Bjorkegren, J. L.; Walker, B. R.; Michoel, T.

10.1101/2023.01.20.524857 — genetics — Posted on 2023-01-21

1373 Increased TCR signaling in regulatory T cells is disengaged from TCR affinity

Jing, Y.; Kong, Y.; Allard, D.; Liu, B.; Kolawole, E.; Sprouse, M.; Evavold, B.; Bettini, M.; Bettini, M.

10.1101/2023.01.17.523999 — immunology — Posted on 2023-01-21

1374 Small Training Dataset Convolutional Neural Networks for Application Specific Super-Resolution Microscopy

Mannam, V.; Howard, S.

10.1101/2022.08.29.505633 — neuroscience — Posted on 2023-01-21

1375 A Generative Model of Memory Construction and Consolidation

Spens, E.; Burgess, N.

10.1101/2023.01.19.524711 — neuroscience — Posted on 2023-01-21

1376 Adaptive delayed feedback control disrupts unwanted neuronal oscillations and adjusts to network synchronization dynamics

Castro, D.; Aroso, M.; Aguiar, P.; Grayden, D.; Aguiar, P.

10.1101/2022.07.05.498735 — neuroscience — Posted on 2023-01-21

1377 Regulation of PYR/PYL/RCAR ABA receptors mRNA stability: involvement of miR5628 in decay of PYL6 mRNA

Vieira, J. G. P.; Duarte, G. T.; Barrera-Rojas, C. H.; Matiolli, C. C.; Viana, A. J. C.; Canesin, L. E. D.; Vicentini, R.; Nogueira, F. T.; Vincentz, M. G. A.

10.1101/2023.01.17.524441 — plant biology — Posted on 2023-01-21

1378 Optical modulation of excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes

Vurro, V.; Federici, B.; Ronchi, C.; Florindi, C.; Sesti, V.; Crasto, S.; Maniezzi, C.; Galli, C.; Antognazza, M. R.; Bertarelli, C.; Di Pasquale, E.; Lanzani, G.; Lodola, F.

10.1101/2022.09.22.508828 — bioengineering — Posted on 2023-01-21

1379 Cryo-EM structure of DNA polymerase θ helicase domain in complex with inhibitor novobiocin

guo, H.; wang, Y.; mao, J.; zhao, H.; he, Y.; hu, Y.; li, J.; li, Y.; guan, Z.; guo, C.; ni, X.; zhang, F.; heng, J.

10.1101/2023.01.20.524915 — biochemistry — Posted on 2023-01-21

1380 Survival of environmental DNA in sediments: Mineralogic control on DNA taphonomy

Freeman, C. L.; Dieudonne, L.; Agbaje, O. B. A.; Zure, M.; Q. Sanz, J.; Collins, M. J.; Sand, K. K.

10.1101/2020.01.28.922997 — biochemistry — Posted on 2023-01-21

1381 Phenome-wide analysis identifies parent-of-origin effects on the human methylome associated with changes in the rate of aging

Gao, C.; Amador, C.; Walker, R. M.; Campbell, A.; Madden, R. A.; Adams, M. J.; Bai, X.; Liu, Y.; Li, M.; Hayward, C.; Porteous, D. J.; Shen, X.; Evans, K. L.; Haley, C.; McIntosh, A.; Navarro, P.; Zeng, Y.

10.1101/2023.01.18.524653 — genetics — Posted on 2023-01-21

1382 Latitudinal gradient in avian insectivory: complementary effects of climate, habitat and bird diversity

SCHILLE, L.; VALDES-CORRECHER, E.; ARCHAUX, F.; BALACENOIU, F.; BJOERN, M. C.; BOGDZIEWICZ, M.; BOIVIN, T.; BRANCO, M.; DAMESTOY, T.; DE GROOT, M.; DOBROSAVLJEVIC, J.; DUDUMAN, M.-L.; DULAURENT, A.-M.; GREEN, S.; GRUNWALD, J.; EOTVOS, C. B.; FATICOV, M.; FERNANDEZ-CONRADI, P.; FLURY, E.; FUNOSAS, D.; GALMAN, A.; GOSSNER, M. M.; GRIPENBERG, S.; GROSU, L.; Hagge, J.; HAMPE, A.; HARVEY, D.; HOUSTON, R.; ISENMANN, R.; KAVCIC, A.; KOZLOV, M. V.; LANTA, V.; LE TILLY, B.; LOPEZ VAAMONDE, C.; MALLICK, S.; MANTYLA, E.; MARELL, A.; MILANOVIC, S.; MOLNAR, M.; MOREIRA, X.; MOSER, V.; MRAZOVA, A.; MUSOLIN,

10.1101/2023.01.19.524212 — ecology — Posted on 2023-01-21

1383 Whole transcriptome profiling of placental pathobiology in SARS-CoV-2 pregnancies identifies a preeclampsia-like gene signature

Stylianou, N.; Sebina, I.; Matigian, N.; Deohler, H.; Monkman, J.; Rohl, J.; Allenby, M.; Nam, A.; Pan, L.; Rockstroh, A.; Sadeghirad, H.; Chung, K.; Sobanski, T.; O'Byrne, K.; Rebutini, P. Z.; Machado-Souza, C.; Stonoga, E. T. S.; Warkiani, M. E.; Salomon, C.; Short, K. R.; McClements, L.; de Noronha, L.; Huang, R. Y.-J.; Belz, G.; Guimaraes, F.; Clifton, V.; Kulasinghe, A.

10.1101/2023.01.20.524893 — developmental biology — Posted on 2023-01-21

1384 SARS-CoV-2 Omicron XBB.1.5 may be a cautionary variant by in silico study

Sugano, A.; Kataguchi, H.; Ohta, M.; Someya, Y.; Kimura, S.; Maniwa, Y.; Tabata, T.; Takaoka, Y.

10.1101/2023.01.18.524660 — bioinformatics — Posted on 2023-01-21

1385 Mechanisms of Premotor-Motor Cortex Interactions during Goal Directed Behavior

Alyahyay, M.; Kalweit, G.; Kalweit, M.; Karvat, G.; Ammer, J.; Schneider, A.; Adzemovic, A.; Vlachos, A.; Boedecker, J.; Diester, I.

10.1101/2023.01.20.524944 — neuroscience — Posted on 2023-01-21

1386 Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas

Rebecca, V. W.; Xiao, M.; Kossenkov, A.; Godok, T.; Brown, G. S.; Fingerman, D.; Alicea, G. M.; Wei, M.; Ji, H.; Bravo, J.; Chen, Y.; Fane, M. E.; Villanueva, J.; Nathanson, K. L.; Liu, Q.; Gopal, Y. N. V.; Daies, M. A.; Herlyn, M.

10.1101/2023.01.20.524923 — cancer biology — Posted on 2023-01-21

1387 SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis

Theard, P. L.; Linke, A. J.; Sealover, N. E.; Daley, B. R.; Yang, J.; Cox, K.; Kortum, R. L.

10.1101/2023.01.20.524989 — cancer biology — Posted on 2023-01-21

1388 The molecular mechanism of selective and active transport in a Na+/Ca2+ exchanger

Marinelli, F.; Faraldo-Gomez, J. D.

10.1101/2023.01.20.524959 — biophysics — Posted on 2023-01-21

1389 A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 is linked to neurodevelopmental disorders

Gonzalez, A. J.; Kim, H. J.; Freibaum, B. D.; Brautigam, C.; Taylor, J. P.; Chook, Y. M.

10.1101/2023.01.20.524964 — biophysics — Posted on 2023-01-21

1390 Structural preferences shape the entropic force of disordered protein ensembles

Yu, F.; Sukenik, S.

10.1101/2023.01.20.524980 — biophysics — Posted on 2023-01-21

1391 Single molecule visualization of native centromeric nucleosome formation reveals coordinated deposition by kinetochore proteins and centromere DNA sequence

Popchock, A.; Larson, J.; Dubrulle, J.; Asbury, C. L.; Biggins, S.

10.1101/2023.01.20.524981 — biophysics — Posted on 2023-01-21

1392 TCGAnalyzeR: a web application for integrative visualization of molecular and clinical data of cancer patients for cohort discovery

Zengin, T.; Abak Masud, B.; Onal-Suzek, T.

10.1101/2023.01.20.524925 — bioinformatics — Posted on 2023-01-21

1393 High tissue-specificity of lncRNAs maximises the prediction of tissue of origin of circulating DNA

Mouhou, E.; Genty, F.; El Mselmi, W.; Chouali, H.; Zagury, J.-F.; Le Clerc, S.; Proudhon, C.; Noirel, J.

10.1101/2023.01.19.524838 — bioinformatics — Posted on 2023-01-21

1394 Prediction Analysis of Preterm Neonates Mortality using Machine Learning Algorithms via Python Programming

Monfared, V.; Hashemi, A.

10.1101/2023.01.20.524905 — bioinformatics — Posted on 2023-01-21

1395 Accurate age prediction from blood using of small set of DNA methylation sites and a cohort-based machine learning algorithm

Varshavsky, M.; Harari, G.; Glaser, B.; Dor, Y.; Shemer, R.; Kaplan, T.

10.1101/2023.01.20.524874 — bioinformatics — Posted on 2023-01-21

1396 Sample size calculation for a NanoString GeoMx spatial transcriptomics experiment to study predictors of fibrosis progression in non-alcoholic fatty liver disease

Ryaboshapkina, M.; Azzu, V.

10.1101/2023.01.20.524846 — bioinformatics — Posted on 2023-01-21

1397 mini-MEndR: A miniaturized 96-well predictive assay to evaluate muscle stem cell mediated repair

Gulati, N.; Davoudi, S.; Xu, B.; Rjaibi, S. T.; Jacques, E.; Pham, J.; Fard, A.; McGuigan, A. P.; Gilbert, P. M.

10.1101/2023.01.20.524941 — bioengineering — Posted on 2023-01-21

1398 Characterizing Mineral Ellipsoids in New Bone Formation at the Interface of Ti6Al4V Porous Implants

Deering, J.; Chen, J.; Mahmoud, D.; Tang, T.; Lin, Y.; Fang, Q.; Wohl, G. R.; Elbestawi, M.; Grandfield, K.

10.1101/2023.01.20.524810 — bioengineering — Posted on 2023-01-21

1399 Improved Isolation of Extracellular Vesicles by Removal of Both Free Proteins and Lipoproteins

Ter-Ovanesyan, D.; Gilboa, T.; Budnik, B.; Nikitina, A.; Whiteman, S.; Lazarovits, R.; Trieu, W.; Kalish, D.; Church, G. M.; Walt, D. R.

10.1101/2023.01.20.524891 — bioengineering — Posted on 2023-01-21

1400 StratoMod: Predicting sequencing and variant calling errors with interpretable machine learning

Dwarshuis, N. J.; Tonner, P.; Olson, N. D. M.; Sedlazeck, F.; Wagner, J.; Zook, J.

10.1101/2023.01.20.524401 — genomics — Posted on 2023-01-21

1401 Computational Analysis of Maize Enhancer Regulatory Elements Using ATAC-STARR-seq

Marand, A. P.

10.1101/2023.01.20.524917 — genomics — Posted on 2023-01-21

1402 Base editing as a genetic treatment for spinal muscular atrophy

Alves, C. R. R.; Ha, L. L.; Yaworski, R.; Lazzarotto, C. R.; Christie, K. A.; Reilly, A.; Beauvais, A.; Doll, R. M.; de la Cruz, D.; Maguire, C. A.; Swoboda, K. J.; Tsai, S. Q.; Kothary, R.; Kleinstiver, B. P.

10.1101/2023.01.20.524978 — genetics — Posted on 2023-01-21

1403 Fine scale sampling reveals spatial heterogeneity of rhizosphere microbiome in young Brachypodium plants

Acharya, S. M.; Yee, M. O.; Diamond, S.; Andeer, P. F.; Baig, N. F.; Aladesanmi, O. T.; Northen, T. R.; Banfield, J. F.; Chakraborty, R.

10.1101/2023.01.20.524947 — ecology — Posted on 2023-01-21

1404 The impact of selected abiotic factors on zooplankton hatching process through real-time, in-situ observation

Dey, P.; Bradley, T. M.; Boymelgreen, A.

10.1101/2023.01.20.524934 — ecology — Posted on 2023-01-21

1405 YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulated bone development

Collins, J. M.; Lang, A.; Parisi, C.; Moharrer, Y.; Nijsure, M. P.; Kim, J. H.; Szeto, G. L.; Qin, L.; Gottardi, R.; Dyment, N.; Nowlan, N.; Boerckel, J. D.

10.1101/2023.01.20.524918 — developmental biology — Posted on 2023-01-21

1406 Anoctamin 10/TMEM16K mediates convergent extension and tubulogenesis during notochord formation in the early chordate Ciona intestinalis.

Liang, Z.; Dondorp, D.; Chatzigeorgiou, M.

10.1101/2023.01.20.524945 — developmental biology — Posted on 2023-01-21

1407 Abnormal chondrocyte intercalation in a zebrafish model of cblC syndrome restored by an MMACHC cobalamin binding mutant.

Paz, D.; Pinales, B. E.; Castellanos, B. S.; Perez, I.; Gil, C. B.; Jimenez-Madrigal, L.; Reyes-Nava, N. G.; Castro, V. L.; Sloan, J. L.; Quintana, A. M.

10.1101/2023.01.20.524982 — developmental biology — Posted on 2023-01-21

1408 Wolbachia is a nutritional symbiont

Lindsey, A. R.; Parish, A. J.; Newton, I. L.; Tennessen, J.; Jones, M. W.; Stark, N.

10.1101/2023.01.20.524972 — developmental biology — Posted on 2023-01-21

1409 Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure

Mao, H.; Szafranska, K.; Kruse, L.; Holte, C.; Wolfson, D. L.; Ahluwalia, B. S.; Whitchurch, C. B.; Cole, L.; Lockwood, G. P.; Diekmann, R.; Le Couteur, D. G.; Cogger, V. C.; McCourt, P. A. G.

10.1101/2023.01.20.524909 — cell biology — Posted on 2023-01-21

1410 Woronin bodies move dynamically and bidirectionally by hitchhiking on early endosomes in Aspergillus nidulans

Songster, L. D.; Bhuyan, D.; Christensen, J. R.; Reck-Peterson, S. L.

10.1101/2023.01.20.524968 — cell biology — Posted on 2023-01-21

1411 Microbial methane cycling in a landfill on a decadal time scale

Gregoire, D. S.; George, N. A.; Hug, L. A.

10.1101/2023.01.20.524919 — microbiology — Posted on 2023-01-21

1412 Cytotrophoblast cells are selectively permissive and favor Zika virus, but no other related flavivirus, invasion to the placental stroma

Viettri, M. I.; Caraballo, G. I.; Sanchez, M. E.; Espejel-Nunez, A.; Betanzos, A.; Ortiz-Navarrete, V.; Estrada, G.; Nava, P.; Ludert, J. E.

10.1101/2023.01.20.524913 — microbiology — Posted on 2023-01-21

1413 Ultrastructural identification and molecular characterization of two new parabasalid species that naturally colonize laboratory mice, Tritrichomonas musculus and Tritrichomonas casperi

Tuzla, L.; Alves-Ferreira, E. V. C.; Kennard, A.; Shehata, C.; Schwartz, C.; Grigg, M. E.

10.1101/2023.01.20.524969 — microbiology — Posted on 2023-01-21

1414 Graph-pMHC: Graph Neural Network Approach to MHC Class II Peptide Presentation and Antibody Immunogenicity

Thrift, W. J.; Perera, J.; Cohen, S.; Lounsbury, N.; Gurung, H.; Rose, C.; Chen, J.; Jhunjhunwala, S.; Liu, K.

10.1101/2023.01.19.524779 — immunology — Posted on 2023-01-21

1415 Keratinocytes coordinate inflammatory responses and regulate development of secondary lymphedema

Park, H.; Kataru, R. P.; Shin, J.; Garcia Nores, G. D.; Encarnacion, E. M.; Klang, M. G.; Riedel, E.; Coriddi, M.; Dayan, J. H.; Mehrara, B. J.

10.1101/2023.01.20.524936 — immunology — Posted on 2023-01-21

1416 Impact of acquisition and modeling parameters on test-retest reproducibility of edited GABA+

Hupfeld, K. E.; Zollner, H. J.; Hui, S. C. N.; Song, Y.; Murali Manohar, S.; Yedavalli, V.; Oeltzschner, G.; Prisciandaro, J. J.; Edden, R. A. E.

10.1101/2023.01.20.524952 — neuroscience — Posted on 2023-01-21

1417 A machine learning approach to quantify individual gait responses to ankle exoskeletons

Ebers, M. R.; Rosenberg, M. C.; Kutz, J. N.; Steele, K. M.

10.1101/2023.01.20.524757 — neuroscience — Posted on 2023-01-21

1418 PPAR-γ is a promising therapeutic target for memory deficits induced by early alcohol exposure.

Garcia-Baos, A.; Pastor, A.; Gallego-Landin, I.; de la Torre, R.; Sanz, F.; Valverde, O.

10.1101/2023.01.20.524912 — neuroscience — Posted on 2023-01-21

1419 Microglia Proliferation Underlies Synaptic Dysfunction in the Prefrontal Cortex: Implications for the Pathogenesis of HIV-1-Associated Neurocognitive and Affective Alterations

Li, H.; McLaurin, K. A.; Mactutus, C. F.; Booze, R. M.

10.1101/2023.01.20.524942 — neuroscience — Posted on 2023-01-21

1420 Sex and estrous cycle stage shape left-right asymmetry in chronic hippocampal seizures in mice

Cutia, C. A.; Leverton, L. K.; Christian-Hinman, C. A.

10.1101/2023.01.20.524965 — neuroscience — Posted on 2023-01-21

1421 Assessment of white matter hyperintensity severity using multimodal MRI in Alzheimer's Disease

Parent, O.; Bussy, A.; Devenyi, G. A.; Dai, A.; Costantino, M.; Tullo, S.; Salaciak, A.; Bedford, S. A.; Farzin, S.; Beland, M.-L.; Valiquette, V.; Villeneuve, S.; Poirier, J.; Tardif, C. L.; Dadar, M.; the PREVENT-AD Research Group, ; Chakravarty, M.

10.1101/2023.01.20.524929 — neuroscience — Posted on 2023-01-21

1422 Source Localization Using Recursively Applied and Projected MUSIC with Flexible Extent Estimation

Hecker, L.; Tebartz van Elst, L.; Kornmeier, J.

10.1101/2023.01.20.524892 — neuroscience — Posted on 2023-01-21

1423 Adaptive robustness through incoherent signaling mechanisms in a regenerative brain

Wang, B.; Bray, S. R.; Wyss, L. S.; Chai, C.; Lozada, M. E.

10.1101/2023.01.20.523817 — neuroscience — Posted on 2023-01-21

1424 High sensitivity proteome-scale search for crosslinked peptides using CRIMP 2.0

Crowder, D. A.; Sarpe, V.; Amaral, B. C.; Brodie, N. I.; Michael, A. R. M.; Schriemer, D. C. C.

10.1101/2023.01.20.524983 — systems biology — Posted on 2023-01-21

1425 Identification of novel sex determination loci in Japanese weedy melon

Nashiki, A.; Matsuo, H.; Takano, K.; Fitriyah, F.; Isobe, S.; Shirasawa, K.; Yoshioka, Y.

10.1101/2023.01.20.524881 — plant biology — Posted on 2023-01-21

1426 Fusion of dysfunction muscle stem cells with myofibers induces sarcopenia in mice.

Wang, X.; Mishra, P.

10.1101/2023.01.20.524967 — physiology — Posted on 2023-01-21

1427 Performing Roux-N Y Gastric Bypass on Rabbits: Perspective Report to Evaluate Body Weight Changes Food Consumption, And the Malabsorption of Vitamin D3

Al Meanazel, O.; Alanazi, F. K.; Hailat, M.; Abu Dayyih, W.; Al-Shdefat, R.; Abu Assab, M.; Awad, R.; Al-Ani, I.; Shakeel, F.; Alshora, D. H.; Ibrahim, M. A.

10.1101/2023.01.20.524848 — pharmacology and toxicology — Posted on 2023-01-21

1428 Genomic profiling and pre-clinical modelling of breast cancer leptomeningeal metastasis (BCLM) reveals acquisition of a lobular-like phenotype

Fitzpatrick, A.; Iravani, M.; Mills, A.; Vicente, D.; Alaguthurai, T.; Roxanis, I.; Turner, N. C.; Haider, S.; Tutt, A. N. J.; Isacke, C.

10.1101/2023.01.20.524591 — cancer biology — Posted on 2023-01-21

1429 4CAC: 4-class classification of metagenome assembliesusing machine learning and assembly graphs

Pu, L.; Shamir, R.

10.1101/2023.01.20.524935 — bioinformatics — Posted on 2023-01-21

1430 Incorporating metabolic activity, taxonomy and community structure to improve microbiome-based predictive models for host phenotype prediction

Monshizadeh, M.; Ye, Y.

10.1101/2023.01.20.524948 — bioinformatics — Posted on 2023-01-21

1431 Vascularised Cardiac Spheroids-on-a-Chip for Testing the Toxicity of Therapeutics

di Cio, S.; Haddrick, M.; Gautrot, J.

10.1101/2023.01.20.524970 — bioengineering — Posted on 2023-01-21

1432 The revised leopard gecko (Eublepharis macularius) reference genome provides insight into the considerations of genome phasing and assembly

Pinto, B. J.; Gamble, T.; Smith, C. H.; Keating, S. E.; Havird, J. C.; Chiari, Y.

10.1101/2023.01.20.523807 — genomics — Posted on 2023-01-21

1433 Measuring the long arm of childhood in real-time: Epigenetic predictors of BMI and social determinants of health across childhood and adolescence

Raffington, L.; Schneper, L.; Mallard, T. T.; Fisher, J.; Vinnik, L.; Hollis-Hansen, K.; Notterman, D. A.; Tucker-Drob, E. M.; Harden, K. P.

10.1101/2023.01.20.524709 — genomics — Posted on 2023-01-21

1434 High quality genome and transcriptome data for two new species of Mantamonas, a deep-branching eukaryote clade

Blaz, J.; Galindo, L. J.; Heiss, A. A.; Kaur, H.; Torruella, G.; Yang, A.; Thompson, A.; Filbert, A.; Warring, S.; Narechania, A.; Shiratori, T.; Ishida, K.-i.; Dacks, J.; Lopez-Garcia, P.; Moreira, D.; Kim, E.; Eme, L.

10.1101/2023.01.20.524885 — genomics — Posted on 2023-01-21

1435 Gene networks driven by genetic variation for plasma cortisol in hepatic and adipose tissues implicate corticosteroid binding globulin in modulating tissue glucocorticoid action and cardiovascular risk

Bankier, S.; Wang, L.; Crawford, A.; Morgan, R. A.; Ruusalepp, A.; Andrew, R.; Bojrkegren, J. L.; Walker, B. R.; Michoel, T.

10.1101/2023.01.20.524857 — genetics — Posted on 2023-01-21

1436 Incorporating fire-smartness into agricultural policies minimises suppression costs and ecosystem services damages from wildfires

Lecina-Diaz, J.; Chas-Amil, M.-L.; Aquilue, N.; Sil, A.; Brotons, L.; Regos, A.; Touza, J.

10.1101/2023.01.20.524753 — ecology — Posted on 2023-01-21

1437 Causal attribution of agricultural expansion in a small island system using approximate Bayesian computation

Clark, M. C.; Andrews, J.; Kolarik, N.; Omar, M. M.; Hillis, V. C.

10.1101/2023.01.20.524853 — ecology — Posted on 2023-01-21

1438 A novel method for characterising the inter- and intra-lake variability of CH4 emissions: validation and application across a latitudinal transect in the Alpine region

Tomelleri, E.; Scholz, K.; Pighini, S.; Carotenuto, F.; Gioli, B.; Miglietta, F.; Sommaruga, R.; Tonon, G.; Zaldei, A.; Wohlfahrt, G.

10.1101/2023.01.19.524063 — ecology — Posted on 2023-01-21

1439 Characterization of 3D organotypic epithelial tissues reveals tonsil-specific differences in tonic interferon signaling

Jackson, R.; Rajadhyaksha, E. V.; Loeffler, R. S.; Flores, C. E.; Van Doorslaer, K.

10.1101/2023.01.19.524743 — cell biology — Posted on 2023-01-21

1440 Generation of human alveolar epithelial type I cells from pluripotent stem cells

Burgess, C. L.; Huang, J.; Bawa, P.; Alysandratos, K.-D.; Minakin, K.; Morley, M. P.; Babu, A.; Villacorta-Martin, C.; Hinds, A.; Thapa, B. R.; Wang, F.; Matschulat, A. M.; Morrisey, E. E.; Varelas, X.; Kotton, D. N.

10.1101/2023.01.19.524655 — cell biology — Posted on 2023-01-21

1441 Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere length maintenance

Estep, K. N.; Tobias, J. W.; Fernandez, R. J.; Beveridge, B. M.; Johnson, F. B.

10.1101/2023.01.19.524780 — cell biology — Posted on 2023-01-21

1442 Malaria parasite proliferation implicates a resource-dependent counter mechanism

Stuermer, V. S.; Stopper, S.; Binder, P.; Klemmer, A.; Becker, N. B.; Guizetti, J.

10.1101/2023.01.20.524890 — cell biology — Posted on 2023-01-21

1443 Landscape of IGH germline genes of Chiroptera and the pattern of Rhinolophus affinisbat IGH CDR3 repertoire

Ma, L.; Liu, L.; Li, J.; Zhou, H.; Xiao, J.; Ma, Q.; Yao, X.

10.1101/2023.01.20.524863 — immunology — Posted on 2023-01-21

1444 ARPC5 deficiency leads to severe early onset systemic inflammation and early mortality

Sindram, E.; Caballero-Oteyza, A.; Cogata, N.; Huang, S. C. M.; Alizadeh, Z.; Gamez-Diaz, L.; Fazlollahi, M. R.; Peng, X.; Grimbacher, B.; Way, M.; Proietti, M.

10.1101/2023.01.19.524688 — immunology — Posted on 2023-01-21

1445 Damage-induced pyroptosis drives endogenous thymic regeneration viainduction of Foxn1 by purinergic receptor activation

Kinsella, S.; Evandy, C. A.; Cooper, K.; Cardinale, A.; Iovino, L.; deRoos, P.; Hopwo, K. S.; Smith, C. W.; Granadier, D. W.; Sullivan, L. B.; Velardi, E.; Dudakov, J.

10.1101/2023.01.19.524800 — immunology — Posted on 2023-01-21

1446 Immune sensing of food allergens promotes aversive behaviour

Florsheim, E. B.; Bachtel, N. D.; Cullen, J.; Costa Lima, B. G.; Godazgar, M.; Zhang, C.; Carvalho, F.; Gautier, G.; Launay, P.; Wang, A.; Dietrich, M. O.; Medzhitov, R.

10.1101/2023.01.19.524823 — immunology — Posted on 2023-01-21

1447 LACK OF INTERACTIONS BETWEEN PRENATAL IMMUNE ACTIVATION AND delta9-TETRAHYDROCANNABINOL EXPOSURE DURING ADOLESCENCE IN BEHAVIOURS RELEVANT TO SYMPTOM DIMENSIONS OF SCHIZOPHRENIA IN RATS

Moreno-Fernandez, M.; Ucha, M.; Reis de Paiva, R.; Marcos, A.; Ambrosio, E.; Higuera-Matas, A.

10.1101/2023.01.20.524884 — neuroscience — Posted on 2023-01-21

1448 Rectus Femoris Muscle Elasticity and Stiffness Correlates with Maximal Oxygen Consumption in Triathletes

Gavronski, G.; Reimets, A.; Talts, J.; Koovit, I.; Mandel, T.; Viir, R.; Vasar, E.; Veraksits, A.

10.1101/2023.01.20.524872 — physiology — Posted on 2023-01-21

1449 Quantitative proteomics combined with network pharmacology analysis unveils the biological basis of Schisandrin B in treating diabetic nephropathy

Song, J.; zhang, B.; Zhang, H.; Cheng, W.; Liu, P.; Kang, J.

10.1101/2023.01.19.524316 — pharmacology and toxicology — Posted on 2023-01-21

1450 Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA-sequencing datasets

Hazra, R.; Utama, R.; Naik, P.; Dobin, A.; Spector, D.

10.1101/2023.01.20.524887 — cancer biology — Posted on 2023-01-21

1451 Mutual antagonism between glucocorticoid and canonical Wnt signaling pathways in B-cell acute lymphoblastic leukemia

Bergeron, B. P.; Barnett, K. R.; Mobley, R. J.; Hansen, B. S.; Brown, A.; Kodali, K.; Peng, J.; Pruett-Miller, S. M.; Savic, D.

10.1101/2023.01.20.524798 — cancer biology — Posted on 2023-01-21

1452 Spatial determination and prognostic impact of the fibroblast transcriptome in pancreatic ductal adenocarcinoma

Croft, W.; Pearce, H.; Margielewska-Davies, S.; Lim, L.; Nicol, S. M.; Zayou, F.; Blakeway, D.; Marcon, F.; Powell-Brett, S.; Mahon, B.; Merard, R.; Zuo, J.; Middleton, G.; Roberts, K.; Brown, R. M.; Moss, P.

10.1101/2023.01.20.524883 — cancer biology — Posted on 2023-01-21

1453 The mechanics of cephalic furrow formation in the Drosophila embryo

Redowan, N. A.; Holcomb, M. C.; Thomas, J. H.; Blawzdziewicz, J.

10.1101/2023.01.19.524786 — biophysics — Posted on 2023-01-21

1454 Enhanced germination and electrotactic behaviour of Phytophthora palmivora zoospores in weak electric fields.

Moratto, E.; Rothery, S.; Bozkurt, T. O.; Sena, G.

10.1101/2023.01.19.524801 — biophysics — Posted on 2023-01-21

1455 PRE-TRAINING WITH A RATIONAL APPROACH FOR ANTIBODY

Gao, X.; Lai, L.; Cao, C.

10.1101/2023.01.19.524683 — bioinformatics — Posted on 2023-01-21

1456 poolHelper: an R package to help in designing Pool-Seq studies

Carvalho, J.; Faria, R.; Butlin, R. K.; Sousa, V. C.

10.1101/2023.01.20.524733 — bioinformatics — Posted on 2023-01-21

1457 Comparison of force fields to study the zinc-finger containing protein NPL4, a target for Antabuse in cancer therapy

Scrima, S.; Tiberti, M.; Ryde, U.; Lambrughi, M.; Papaleo, E.

10.1101/2023.01.20.524865 — bioinformatics — Posted on 2023-01-21

1458 Visualization and review of reads alignment on the graphical pan-genome with VAG

Li, F.; Hu, H.; Xiao, Z.; Wang, J.; Liu, J.; Zhao, D.; Fu, Y.; Wang, Y.; Yuan, X.; Bu, S.; Zhou, X.; Zhao, J.; Wang, S.

10.1101/2023.01.20.524849 — bioinformatics — Posted on 2023-01-21

1459 Myxosortases process MYXO-CTERM and other bacterial C-terminal protein-sorting signals that have invariant Cys residues.

Haft, D. H.

10.1101/2023.01.19.524832 — bioinformatics — Posted on 2023-01-21

1460 Human VDAC pseudogenes: an emerging role for VDAC1P8 pseudogene in acute myeloid leukemia

Pappalardo, X. G.; Risiglione, P.; Zinghirino, F.; Ostuni, A.; Luciano, D.; Bisaccia, F.; De Pinto, V.; Guarino, F.; Messina, A.

10.1101/2023.01.20.524880 — genomics — Posted on 2023-01-21

1461 FLInt: Single Shot Safe Harbor Transgene Integration via Fluorescent Landmark Interference

Malaiwong, N.; Porta-de-la-Riva, M.; Krieg, M.

10.1101/2023.01.19.524728 — genetics — Posted on 2023-01-21

1462 Emergence and maintenance of stable coexistence during a long-term multicellular evolution experiment

Pineau, R.; Demory, D.; Libby, E.; Lac, D. T.; Day, T.; Bravo, P.; Weitz, J.; Yunker, P. J.; Bozdag, G. O.; Ratcliff, W. C.

10.1101/2023.01.19.524803 — evolutionary biology — Posted on 2023-01-21

1463 Evidence of phylosymbiosis in Formica ants

Jackson, R.; Patapiou, P. A.; Golding, G.; Helantera, H.; Economou, C. K.; Chapuisat, M.; Henry, L. M.

10.1101/2023.01.20.524858 — evolutionary biology — Posted on 2023-01-21

1464 Genomic signatures of past megafrugivore-mediated dispersal in Malagasy palms

Mendez, L.; Barratt, C. D.; Durka, W.; Kissling, W. D.; Eiserhardt, W. L.; Baker, W. J.; Randrianasolo, V.; Onstein, R. E.

10.1101/2023.01.20.524701 — evolutionary biology — Posted on 2023-01-21

1465 Effects of assisted gene flow on the flowering onset of the annual legume Lupinus angustifolius L.: from phenotype to genotype.

Sacristan-Bajo, S.; Lara-Romero, C.; Garcia-Fernandez, A.; Prieto-Benitez, S.; Morente-Lopez, J.; Rubio Teso, M. L.; Torres, E.; Iriondo, J. M.

10.1101/2023.01.20.524742 — evolutionary biology — Posted on 2023-01-21

1466 Rapid turnover and evolution of sex-determining regions among Sebastes rockfishes

Sykes, N. T. B.; Kolora, S. R. R.; Sudmant, P. H.; Owens, G. L.

10.1101/2023.01.19.524770 — evolutionary biology — Posted on 2023-01-21

1467 Facilitative interaction networks in experimental microbial community dynamics

Fujita, H.; Ushio, M.; Suzuki, K.; Abe, M. S.; Yamamichi, M.; Okazaki, Y.; Canarini, A.; Hayashii, I.; Fukushima, K.; Fukuda, S.; Kiers, T.; Toju, H.

10.1101/2023.01.19.524804 — ecology — Posted on 2023-01-21

1468 Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate

Oichi, T.; Kodama, J.; Wilson, K.; Tian, H.; Kawasawa, Y. I.; Usami, Y.; Oshima, Y.; Saito, T.; Tanaka, S.; Iwamoto, M.; Otsuru, S.; Enomoto-Iwamoto, M.

10.1101/2023.01.20.524764 — developmental biology — Posted on 2023-01-21

1469 Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial metabolic reprogramming

Wang, Y.; Kulkarni, V. V.; Pantaleon Garcia, J.; Leiva-Juarez, M. M.; Goldblatt, D. L.; Gulraiz, F.; Chen, J.; Donepudi, S. R.; Lorenzi, P. L.; Wang, H.; Wong, L.-J.; Tuvim, M. J.; Evans, S. E.

10.1101/2023.01.19.524841 — immunology — Posted on 2023-01-21

1470 Neuroimmune cortical organoids overexpressing C4A exhibit multiple schizophrenia endophenotypes

Stanton, M. M.; Modan, S.; Taylor, P. M.; Hariani, H. N.; Sorokin, J.; Rash, B. G.; Rao, S. B.; Lopez-Tobon, A.; Enriquez, L.; Dang, B.; Owango, D.; O'Neill, S.; Castrillo, C.; Nicola, J.; Ye, K.; Blattner, R. M.; Gonzalez, F.; Antonio, D.; Ramkumar, P.; Lash, A.; Flanzer, D.; Bardehle, S.; Gyoneva, S.; Shah, K.; Kato, S.; Skibinski, G.

10.1101/2023.01.20.524955 — neuroscience — Posted on 2023-01-20

1471 Population-level comparisons of gene regulatory networks modeled on high-throughput single-cell transcriptomics data.

Osorio, D.; Capasso, A.; Eckhardt, S. G.; Giri, U.; Somma, A.; Pitts, T. M.; Lieu, C. H.; Messersmith, W. A.; Bagby, S. M.; Singh, H.; Das, J.; Sahni, N.; Yi, S. S.; Kuijjer, M. L.

10.1101/2023.01.20.524974 — bioinformatics — Posted on 2023-01-20

1472 Evidence for vocal signatures and voice-prints in a wild parrot

Smeele, S. Q.; Senar, J. C.; Aplin, L. M.; McElreath, M. B.

10.1101/2023.01.20.524864 — animal behavior and cognition — Posted on 2023-01-20

1473 A novel description of the network dynamics underpinning working memory

Rossi, C.; Vidaurre, D.; Costers, L.; Akbarian, F.; Woolrich, M.; Nagels, G.; Van Schependom, J.

10.1101/2023.01.20.524895 — neuroscience — Posted on 2023-01-20

1474 Threat and reward imminence processing in the human brain

Murty, D. V. P. S.; Song, S.; Surampudi, S. G.; Pessoa, L.

10.1101/2023.01.20.524987 — neuroscience — Posted on 2023-01-20

1475 Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins

Avolio, R.; Agliarulo, I.; Criscuolo, D.; Sarnataro, D.; Auriemma, M.; Pennacchio, S.; Calice, G.; Ng, M. Y.; Giorgi, C.; Pinton, P.; Cooperman, B.; Landriscina, M.; Esposito, F.; Matassa, D. S.

10.1101/2023.01.19.524708 — biochemistry — Posted on 2023-01-20

1476 SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

Daley, B.; Vieira, H. M.; Rao, C.; Hughes, J. M.; Huisman, D. H.; Chatterjee, D.; Sealover, N. E.; Cox, K.; Askew, J. W.; Svoboda, R. A.; Fisher, K. W.; Lewis, R. E.; Kortum, R. L.

10.1101/2022.12.06.519395 — cancer biology — Posted on 2023-01-20

1477 A Parametric Blueprint for Optimum Cochlear Outer Hair Cell Design

Rabbitt, R. D.; Bidone, T. C.

10.1101/2022.10.11.511831 — biophysics — Posted on 2023-01-20

1478 Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

Shin, H.; Leung, A.; Costello, K. R.; Senapati, P.; Kato, H.; Lee, M.; Lin, D.; Tang, X.; Chen, Z. B.; Schones, D. E.

10.1101/2022.05.11.491514 — molecular biology — Posted on 2023-01-20

1479 Organizing memories for generalization in complementary learning systems

Sun, W.; Advani, M.; Spruston, N.; Saxe, A.; Fitzgerald, J. E.

10.1101/2021.10.13.463791 — neuroscience — Posted on 2023-01-20

1480 NEK1-Mediated Phosphorylation of YAP1 is key to Prostate Cancer Progression

Ghosh, I.; Khalil, I. M.; Mirza, R.; King, J.; Olatunde, D.; De Benedetti, A.

10.1101/2023.01.03.522575 — cancer biology — Posted on 2023-01-20

1481 NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data

Bahl, E.; Chatterjee, S.; Mukherjee, U.; Elsadany, M.; Vanrobaeys, Y.; Lin, L.-C.; McDonough, M.; Resch, J.; Giese, K. P.; Abel, T.; Michaelson, J.

10.1101/2022.04.08.487573 — bioinformatics — Posted on 2023-01-20

1482 Characterizing the landscape of viral expression in cancer by deep learning

Elbasir, A.; Ye, Y.; Schaffer, D. E.; Hao, X.; Wickramasinghe, J.; Tsingas, K.; Lieberman, P. M.; Long, Q.; Morris, Q. M.; Zhang, R.; Schaffer, A. A.; Auslander, N.

10.1101/2022.06.26.497658 — bioinformatics — Posted on 2023-01-20

1483 3D printed magneto-active microfiber scaffolds for remote stimulation of 3D in vitro skeletal muscle models

Cedillo Servin, G.; Dahri, O.; Meneses, J.; van Duijn, J.; Sage, F.; Silva, J.; Pereira, A.; Magalhaes, F. D.; Malda, J.; Geijsen, N.; M. Pinto, A.; Castilho, M.

10.1101/2023.01.19.524679 — bioengineering — Posted on 2023-01-20

1484 Absolute quantification of photoreceptor outer segment proteins

Skiba, N. P.; Lewis, T. R.; Spencer, W. J.; Castillo, C. M.; Shevchenko, A.; Arshavsky, V. Y.

10.1101/2023.01.19.524794 — biochemistry — Posted on 2023-01-20

1485 CHD-associated enhancers shape human cardiomyocyte lineage commitment

Armendariz, D. A.; Goetsch, S. C.; Sundarrajan, A.; Sivakumar, S.; Wang, Y.; Xie, S.; Munshi, N. V.; Hon, G. C.

10.1101/2022.04.07.487515 — genomics — Posted on 2023-01-20

1486 Combinatorial single-cell profiling of all major chromatin types with MAbID

Lochs, S. J. A.; van der Weide, R. H.; de Luca, K. L.; Korthout, T.; van Beek, R. E.; Kimura, H.; Kind, J.

10.1101/2023.01.18.524584 — genomics — Posted on 2023-01-20

1487 Captive rearing effects on the methylome of Atlantic salmon after oceanic migration: sex-specificity and intergenerational stability

Venney, C. J.; Bouchard, R.; April, J.; Normandeau, E.; Lecomte, L.; Cote, G.; Bernatchez, L.

10.1101/2022.10.03.510655 — evolutionary biology — Posted on 2023-01-20

1488 Change in Monarch Butterfly Winter Abundance Over the Past Decade: A Red List Perspective

Meehan, T. D.; Crossley, M. S.

10.1101/2023.01.12.523862 — ecology — Posted on 2023-01-20

1489 Basis for the phototaxis sign reversal in the green alga Chlamydomonas reinhardtii studied by high-speed observation

Nakajima, M.; Iizuka, K.; Takahashi, R.; Ueki, N.; Isu, A.; Yoshimura, K.; Nakagaki, T.; Hisabori, T.; Sato, K.; Wakabayashi, K.-i.

10.1101/2020.12.06.414052 — cell biology — Posted on 2023-01-20

1490 BAZ2A-RNA mediated association with TOP2A and KDM1A represses gene expression in prostate cancer

Roganowicz, M.; Baer, D.; Bersaglieri, C.; Aprigliano, R.; Santoro, R.

10.1101/2021.07.15.452487 — molecular biology — Posted on 2023-01-20

1491 Microbial fingerprints reveal interaction between museum objects, curators and visitors

Simon, L.; Flocco, C.; Henke, D. M.; Rauer, L.; Müller, C.; Vogel, J.; Quassier, C.; Overmann, J.; Simon, S.

10.1101/2023.01.04.522779 — microbiology — Posted on 2023-01-20

1492 Inflammatory CD4/CD8 double positive human T cells arise from reactive CD8 T cells and are sufficient to mediate GVHD pathology

Hess, N. J.; Turicek, D. P.; Riendeau, J.; McIlwain, S. J.; Contreras Guzman, E.; Nadiminti, K.; Hudson, A.; Callander, N. S.; Skala, M. C.; Gumperz, J. E.; Hematti, P.; Capitini, C. M.

10.1101/2022.01.11.475845 — immunology — Posted on 2023-01-20

1493 A causal role of human laryngeal motor cortex in perceptual decision of lexical pitch and voicing

Liang, B.; Li, Y.; Zhao, W.; Du, Y.

10.1101/2022.04.12.487725 — neuroscience — Posted on 2023-01-20

1494 Synergic homology directed recombination by PRDM9 meiotic factor

Sanvicente, M.; Gonzalez-Bermudez, L.; Turpin, I.; Batlle, L.; Acosta, S.; Guell, M.; Sanchez-Mejias, A.

10.1101/2022.12.05.519167 — synthetic biology — Posted on 2023-01-20

1495 DNA methylation signatures of duplicate gene evolution in angiosperms

Kenchanmane Raju, S. K.; Ledford, S. M.; Niederhuth, C. E.

10.1101/2020.08.31.275362 — plant biology — Posted on 2023-01-20

1496 Single cell guided deconvolution of bulk transcriptomics recapitulates differentiation stages of acute myeloid leukemia and predicts drug response

Karakaslar, E. O.; Severens, J. F.; Sanchez-Lopez, E.; van Veelen, P. A.; Zlei, M.; van Dongen, J. J.; Otte, A. M.; Halkes, C. J.; van Balen, P.; Veelken, H.; Reinders, M. J.; Griffioen, M.; van den Akker, E. B.

10.1101/2022.12.09.519738 — cancer biology — Posted on 2023-01-20

1497 Interactions between terminal RNA helices affect the stability of the Escherichia coli large ribosomal subunit

Nissley, A. J.; Kamal, T. S.; Cate, J. H.

10.1101/2023.01.19.524821 — biophysics — Posted on 2023-01-20

1498 Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes

Prowse, E. N. P.; Chaudhary, A. R.; Sharon, D.; Hendricks, A. G.

10.1101/2022.05.27.493751 — biophysics — Posted on 2023-01-20

1499 Analysis of noisy transient signals based on Gaussian process regression

Baglaeva, I.; Iaparov, B.; Zahradnik, I.; Zahradnikova, A.

10.1101/2022.09.27.509665 — biophysics — Posted on 2023-01-20

1500 A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

Pabis, K.; Barardo, D.; Selvarajoo, K.; Gruber, J.; Kennedy, B. K.

10.1101/2022.12.29.522277 — bioinformatics — Posted on 2023-01-20

1501 Chiral Graphene Quantum Dots Enhanced Drug Loading into Exosomes

Zhang, Y.; Zhu, Y.; Kim, G.; Wang, C.; Zhu, R.; Lu, X.; Chang, H.-C.; Wang, Y.

10.1101/2023.01.20.523510 — bioengineering — Posted on 2023-01-20

1502 Selection, recombination and population history effects on runs of homozygosity (ROH) in wild red deer (Cervus elaphus)

Hewett, A. M.; Stoffel, M. A.; Peters, L.; Johnston, S. E.; Pemberton, J. M.

10.1101/2023.01.19.524729 — genetics — Posted on 2023-01-20

1503 Target-enriched enzymatic methyl sequencing: flexible, scalable and inexpensive hybridization capture for quantifying DNA methylation

Rubenstein, D. R.; Solomon, J.

10.1101/2022.08.26.505457 — genetics — Posted on 2023-01-20

1504 Spatio-temporal modelling of the effect of selected environmental and land-use factors on species-rich calcareous grasslands: overgrazing and nitrogen deposition

Damgaard, C.

10.1101/2022.11.29.518308 — ecology — Posted on 2023-01-20

1505 High intraspecific growth variability despite strong evolutionary heritage in a neotropical forest

Schmitt, S.; Herault, B.; Derroire, G.

10.1101/2022.07.27.501745 — ecology — Posted on 2023-01-20

1506 Interacting abiotic and biotic drivers shape woody invasions across Hawaiian forests

Craven, D.; Chase, J.; Knight, T.

10.1101/2022.06.01.494375 — ecology — Posted on 2023-01-20

1507 FGF2-induced Redox Signaling: A Mechanism Regulating Pyruvate Dehydrogenase Driven Histone Acetylation and NANOG Upregulation

Fojtik, P.; Senfluk, M.; Holomkova, K.; Salykin, A.; Gregorova, J.; Smak, P.; Pes, O.; Raska, J.; Stetkova, M.; Skladal, P.; Sedlackova, M.; Hampl, A.; Bohaciakova, D.; Uldrijan, S.; Rotrekl, V.

10.1101/2023.01.20.524871 — cell biology — Posted on 2023-01-20

1508 Mutations in NBEAL2 do not impact Weibel-Palade body biogenesis and Von Willebrand factor secretion in Gray Platelet Syndrome Endothelial Colony Forming Cells

Kat, M.; van Moort, I.; Burgisser, P. E.; Kuijpers, T. W.; Hofman, M.; Favier, M.; Favier, R.; Margadant, C.; Voorberg, J.; Bierings, R.

10.1101/2022.06.08.495181 — cell biology — Posted on 2023-01-20

1509 Oligonucleotide-directed proximity-interactome mapping (O-MAP): A unified method for discovering RNA-interacting proteins, transcripts and genomic loci in situ.

Tsue, A. F.; Kania, E. E.; Lei, D. Q.; Fields, R.; McGann, C. C.; Hershberg, E. A.; Deng, X.; Kihiu, M.; Ong, S.-E.; Disteche, C. M.; Kugel, S.; Beliveau, B.; Schweppe, D. K.; Shechner, D. M.

10.1101/2023.01.19.524825 — molecular biology — Posted on 2023-01-20

1510 Novel keto-alkyl-pyridinium antifungal molecules active in models of in vivo Candida albicans vascular catheter infection and ex vivo Candida auris skin colonization

Beattie, S. R.; Esan, T.; Zaronowaki, R.; Eix, E.; Nett, J. E.; Andes, D. R.; Hagen, T.; Krysan, D. J.

10.1101/2023.01.19.524835 — microbiology — Posted on 2023-01-20

1511 Functional characterization of Salmonella Typhimurium encoded YciF, a domain of unknown function (DUF892) family protein, and its role in protection during bile and oxidative stress

Singh, M.; Penmatsa, A.; Nandi, D.

10.1101/2023.01.20.524870 — microbiology — Posted on 2023-01-20

1512 Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses

Garcia, G.; Ignatius Irudayam, J.; Vijay Jeyachandran, A.; Dubey, S.; Chang, C.; Castillo Cario, S.; Price, N.; Arumugam, S.; Marquez, A. L.; Shah, A.; Fanaei, A.; Chakravarty, N.; Joshi, S.; Sinha, S.; French, S. W.; Parcells, M.; Ramaiah, A.; Arumugaswami, V.

10.1101/2023.01.19.524824 — microbiology — Posted on 2023-01-20

1513 Recognition determinants of broad and potent HIV-1 neutralization by an affinity matured antibody from a pediatric elite-neutralizer

Kumar, S.; Singh, S.; Chatterjee, A.; Bajpai, P.; Sharma, S.; Katpara, S.; Lodha, R.; Dutta, S.; Luthra, K.

10.1101/2023.01.19.524673 — immunology — Posted on 2023-01-20

1514 Phage-specific immune responses impair efficacy of phage therapy targeting VRE in a murine model

Berkson, J. D.; Allen, G. B.; Schubert, A. M.; Dunbar, K. E.; Coryell, M. P.; Sava, R. L.; Gao, Y.; Wate, C. E.; Hastie, J. L.; Zimmermann, S. K.; Carlson, P. E.

10.1101/2023.01.19.523600 — immunology — Posted on 2023-01-20

1515 Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

Canales-Herrerias, P.; Uzzan, M.; Seki, A.; Czepielewski, R. S.; Verstockt, B.; Livanos, A.; Raso, F.; Dunn, A.; Dai, D.; Wang, A.; Al-taie, Z.; Martin, J.; Ko, H. M.; Tokuyama, M.; Tankelevich, M.; Meringer, H.; Cossarini, F.; Jha, D.; Krek, A.; Paulsen, J. D.; Zuber Nakadar, M.; Wong, J.; Erlich, E. C.; Onufer, E. J.; Helmink, B. A.; Sharma, K.; Rosenstein, A.; Chung, G.; Dawson, T.; Juarez, J.; Yajnik, V.; Cerutti, A.; Faith, J.; Suarez-Farinas, M.; Argmann, C.; Petralia, F.; Randolph, G. J.; Polydorides, A. D.; Reboldi, A.; Colombel, J. F.; Mehandru, S.

10.1101/2023.01.19.524731 — immunology — Posted on 2023-01-20

1516 Mapping cortical excitability in the human dorsolateral prefrontal cortex

Gogulski, J.; Cline, C. C.; Ross, J. M.; Truong, J.; Sarkar, M.; Parmigiani, S.; Keller, C. J.

10.1101/2023.01.20.524867 — neuroscience — Posted on 2023-01-20

1517 Modulatory feedback explain object segmentation by attention

Papale, P.; Williford, J. R.; Balk, S.; Roelfsema, P. R.

10.1101/2023.01.19.524712 — neuroscience — Posted on 2023-01-20

1518 The effects of aging and hearing impairment on listening in noise

Boncz, A.; Szalardy, O.; Velosy, P. K.; Beres, L.; Winkler, I.; Toth, B.

10.1101/2023.01.20.524873 — neuroscience — Posted on 2023-01-20

1519 Developmental changes in individual alpha frequency: Recording EEG data during public engagement events

Turner, C.; Baylan, S.; Bracco, M.; Cruz, G.; Hanzal, S.; Keime, M.; Kuye, I.; McNeill, D.; Ng, Z.; van der Plas, M.; Ruzzoli, M.; Thut, G.; Trajkovic, J.; Veniero, D.; Wale, S. P.; Whear, S.; Learmonth, G.

10.1101/2023.01.20.524682 — neuroscience — Posted on 2023-01-20

1520 A Unified Physiological Process Links Global Patterns of Functional MRI, Respiratory Activity, and Autonomic Signaling

Bolt, T. S.; Wang, S.; Nomi, J. S.; Setton, R.; Gold, B.; Frederick, B.; Spreng, R. N.; Keilholz, S.; Uddin, L.; Chang, C.

10.1101/2023.01.19.524818 — neuroscience — Posted on 2023-01-20

1521 DISCOVER-EEG: an open, fully automated EEG pipeline for biomarker discovery in clinical neuroscience

Gil Avila, C.; Bott, F. S.; Tiemann, L.; Hohn, V. D.; May, E. S.; Nickel, M. M.; Zebhauser, P. T.; Gross, J.; Ploner, M.

10.1101/2023.01.20.524897 — neuroscience — Posted on 2023-01-20

1522 Dopamine signals encode internally determined subjective value regardless of externally indicated reward attributes

Hill, D. F.; Hickman, R. W.; Al-Mohammad, A.; Stasiak, A.; Schultz, W.

10.1101/2023.01.20.524896 — neuroscience — Posted on 2023-01-20

1523 Gene expression of macaques infected with malaria species of zoonotic concern

Bergey, C. M.; Trujillo, A. E.

10.1101/2023.01.19.524806 — systems biology — Posted on 2023-01-20

1524 Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities

Schott, C. R.; Koehne, A. L.; Sayles, L. C.; Young, E. P.; Luck, C.; Yu, K.; Lee, A. G.; Breese, M. R.; Leung, S. G.; Shah, A. T.; Xu, H.; Liu, H.-Y.; Spillinger, A.; Behroozfard, I. H.; Marini, K. D.; Dinh, P. T.; Pons Ventura, M. V.; Vanderboon, E. N.; Hazard, F. K.; Cho, S.-J.; Avedian, R. S.; Mohler, D. G.; Zimel, M.; Wustrack, R.; Curtis, C.; Sirota, M.; Sweet-Cordero, E. A.

10.1101/2023.01.19.524562 — cancer biology — Posted on 2023-01-20

1525 Functional synapses between small cell lung cancer and glutamatergic neurons

Schmitt, A.; Sakthivelu, V.; Ndoci, K.; Wani, G. A.; Touet, M.; Pintelon, I.; Kisis, I.; Ibruli, O.; Weber, J.; Maresch, R.; Bebber, C. M.; Goergens, J.; Jevtic, M.; Odenthal, F.; Placzek, A.; Hennrich, A. A.; Conzelmann, K.-K.; Boecker, M.; Heimsoeth, A.; Gulculer, G. S.; Jachimowicz, R. D.; George, J.; Bragelmann, J.; von Karstedt, S.; Peifer, M.; Persigehl, T.; Grull, H.; Sos, M. L.; Bruning, J.; Reifenberger, G.; Fischer, M.; Adriaensen, D.; Buttner, R.; Brouns, I.; Rad, R.; Thomas, R. K.; Bergami, M.; Motori, E.; Reinhardt, H. C.; Beleggia, F.

10.1101/2023.01.19.524045 — cancer biology — Posted on 2023-01-20

1526 Structure and its transformation of elliptical nege-like virus Tanay virus

Okamoto, K.; Song, C.; Sakaguchi, M.; Chalkiadaki, C.; Miyazaki, N.; Nabeshima, T.; Morita, K.; Inoue, S.; Murata, K.

10.1101/2023.01.20.523382 — biophysics — Posted on 2023-01-20

1527 Signaling in microbial communities with open boundaries

Winkle, J. J.; Saha, S.; Essman, J.; Bennett, M. R.; Ott, W.; Josic, K. R.; Mugler, A.

10.1101/2023.01.20.524904 — biophysics — Posted on 2023-01-20

1528 Comparison of gene set scoring methods for reproducible evaluation of multiple tuberculosis gene signatures

Wang, X.; Vanvalkenburg, A.; Odom-Mabey, A. R.; Ellner, J. J.; Hochberg, N. S.; Salgame, P.; Patil, P.; Johnson, W. E.

10.1101/2023.01.19.520627 — bioinformatics — Posted on 2023-01-20

1529 Metabolomic characterization of behaviorally manipulated ants with multiomic data integration

Will, I.; Attardo, G. M.; de Bekker, C.

10.1101/2023.01.19.524761 — bioinformatics — Posted on 2023-01-20

1530 The more, the merrier: multivariate phase synchronization methods excel pairwise ones in estimating brain connectivity from reconstructed neural sources

Bruna, R.; Cuesta, P.; Ramirez-Torano, F.; Suarez-Mendez, I.; Pereda, E.

10.1101/2023.01.19.524740 — bioengineering — Posted on 2023-01-20

1531 Ferroptosis Promotes Pulmonary Hypertension

Vogel, N. T.; Annis, J.; Prisco, S.; Kazmirczak, F.; Brittain, E. L.; Prins, K.

10.1101/2023.01.19.524721 — biochemistry — Posted on 2023-01-20

1532 Structural insights into regulation of TRPM7 divalent cation uptake by the small GTPase ARL15

Mahbub, L.; Kozlov, G.; Zong, P.; Tetteh, S.; Nethramangalath, T.; Knorn, C.; Jiang, J.; Shahsavan, A.; Lee, E.; Yue, L.; Runnels, L.; Gehring, K.

10.1101/2023.01.19.524765 — biochemistry — Posted on 2023-01-20

1533 Complex organic matter degradation by secondary consumers in chemolithoautotrophy-based subsurface geothermal ecosystems

Paul, R.; Rogers, T. J.; Fullerton, K. M.; Selci, M.; Cascone, M.; Stokes, M. H.; Steen, A. D.; de Moor, J. M.; Chiodi, A.; Stefansson, A.; Halldorsson, S. A.; Ramirez, C. J.; Jessen, G. L.; Barry, P. H.; Cordone, A.; Giovannelli, D.; Lloyd, K.

10.1101/2023.01.20.524876 — biochemistry — Posted on 2023-01-20

1534 Transcriptional and Histone acetylation changes associated with CRE elements expose key factors governing the regulatory circuit in early stage of Huntington's disease models.

Arancibia-Opazo, S.; Contreras-Riquelme, J. S.; Sanchez, M.; Cisternas-Olmedo, M.; Vidal, R. L.; Martin, A. J. M.; Saez, M. A.

10.1101/2023.01.19.524732 — genomics — Posted on 2023-01-20

1535 A highly discriminatory RNA strand-specific assay to facilitate analysis of the role of cis-acting elements in foot-and-mouth disease virus replication

Dobson, S. J.; Herod, M. R.; Rowlands, D. R.; Stonehouse, N. J.

10.1101/2023.01.20.524889 — molecular biology — Posted on 2023-01-20

1536 Secretory and transcriptomic responses of mantle cells to low pH in the Pacific oyster (Crassostrea gigas)

Zuniga-Soto, N.; Pinto-Borguero, I.; Quevedo, C.; Aguilera, F.

10.1101/2023.01.19.524809 — molecular biology — Posted on 2023-01-20

1537 mRNA decay can be uncoupled from deadenylation during stress response

Czarnocka-Cieciura, A.; Turtola, M.; Tomecki, R.; Krawczyk, P.; Mroczek, S.; Orzel, W.; Saha, U.; Jensen, T. H.; Dziembowski, A.; Tudek, A.

10.1101/2023.01.20.524924 — molecular biology — Posted on 2023-01-20

1538 Immigration and seasonal bottlenecks: High inbreeding despite high genetic diversity in an oscillating population of the biting midge, Culicoides sonorensis (Diptera: Ceratopogonidae)

Shults, P.; Zhang, X.; Moran, M.; Cohnstaedt, L. W.; Gerry, A. C.; Vargo, E. L.; Eyer, P. A.

10.1101/2023.01.19.524819 — molecular biology — Posted on 2023-01-20

1539 Defining the contribution of microRNA-specific slicing Argonautes in animals

Pal, A.; Vasudevan, V.; Houle, F.; Lantin, M.; Maniates, K. A.; Quevillon Huberdeau, M.; Abbott, A.; Simard, M. J.

10.1101/2023.01.19.524781 — molecular biology — Posted on 2023-01-20

1540 Using RNASeq to investigate the involvement of the Ophiocordyceps clock in ant host infection and behavioral manipulation

Das, B.; Will, I.; Brouns, R.; Brachmann, A.; de Bekker, C.

10.1101/2023.01.20.524843 — molecular biology — Posted on 2023-01-20

1541 Archaeal type IV pili stabilize Haloferax volcanii biofilms in flow

Odermatt, P.; Nussbaum, P.; Monnappa, S.; Tala, L.; Li, Z.; Sivabalasarma, S.; Albers, S.-V.; Persat, A.

10.1101/2023.01.20.524888 — microbiology — Posted on 2023-01-20

1542 Human-gut phages harbor sporulation genes

Schwartz, D.; Rodriguez-Ramos, J.; Shaffer, M.; Flynn, R.; Daly, R. A.; Wrighton, K.; Lennon, J. T.

10.1101/2023.01.19.524802 — microbiology — Posted on 2023-01-20

1543 VPg impact on Ryegrass mottle virus serine-like 3C protease proteolysis and structure

Kalnins, G.; Ludviga, R.; Kalnciema, I.; Resevica, G.; Zeltina, V.; Bogans, J.; Tars, K.; Zeltins, A.; Balke, I.

10.1101/2023.01.19.524839 — microbiology — Posted on 2023-01-20

1544 Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver

Tsugawa, H.; Ohki, T.; Tsubaki, S.; Tanaka, R.; Matsuzaki, J.; Suzuki, H.; Hozumi, K.

10.1101/2023.01.19.524842 — microbiology — Posted on 2023-01-20

1545 Fusidic acid-based drug combinations exhibit enhanced activity against Mycobacterium tuberculosis

Omollo, C. O.; Warner, D. F.; Moosa, A.; Chibale, K.

10.1101/2023.01.19.524834 — microbiology — Posted on 2023-01-20

1546 Hospital and urban wastewaters shape the structure and active resistome of environmental biofilms

Buelow, E.; Dauga, C.; Carrion, C.; Mathe-Hubert, H.; Achaibou, S.; Gaschet, M.; Jove, T.; Chesneau, O.; Kennedy, S. P.; Ploy, M.-C.; Da Re, S.; DAGOT, C.

10.1101/2023.01.19.524754 — microbiology — Posted on 2023-01-20

1547 Ralstonia solanacearum pandemic lineage strain UW551 overcomes inhibitory xylem chemistry to break tomato bacterial wilt resistance

Hamilton, C. D.; Zaricor, B.; Dye, C. J.; Dresserl, E.; Allen, C.

10.1101/2023.01.20.523839 — microbiology — Posted on 2023-01-20

1548 Immunological parameters of Proteus mirabilis isolates in Rheumatoid Arthritis patients with urinary tract infections

Abdul, F. R.; Raheem, I. A.; Subhi, H. T.; Fatah, H. R.; Muhammad, H. A.

10.1101/2023.01.20.524875 — microbiology — Posted on 2023-01-20

1549 Function and Importance of Marine Bacterial Transporters of Plankton Exometabolites

Schroer, W. F.; Kepner, H. E.; Uchimiya, M.; Mejia, C.; Trujillo Rodriguez, L.; Reisch, C.; Moran, M. A.

10.1101/2023.01.19.524783 — microbiology — Posted on 2023-01-20

1550 The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression

Hoang, T.-M.; Huang, W.; Gans, J.; Nowak, E. S.; Barbier, M.; Wilks, A.; Kane, M. A.; Oglesby, A. G.

10.1101/2023.01.19.524833 — microbiology — Posted on 2023-01-20

1551 Comprehensive longitudinal study of home-cage activity, including climbing, reveals new complex phenotypic profile in the N171-82Q HD mouse model with implications for refined preclinical studies.

Bains, R. S.; Forrest, H.; Sillito, R.; Armstrong, J. D.; Stewart, M. E.; Nolan, P.; Wells, S.

10.1101/2023.01.19.524755 — neuroscience — Posted on 2023-01-20

1552 Implicit motor adaptation and perceived hand position without proprioception: A kinesthetic error may be derived from efferent signals

Tsay, J. S.; Chandy, A. M.; Chua, R.; Miall, R. C.; Cole, J.; Farne, A.; Ivry, R. B.; Sarlegna, F. R.

10.1101/2023.01.19.524726 — neuroscience — Posted on 2023-01-20

1553 Confidence is predicted by pre- and post-choice decision signal dynamics

Grogan, J. P.; Rys, W.; Kelly, S. P.; O'Connell, R. G.

10.1101/2023.01.19.524702 — neuroscience — Posted on 2023-01-20

1554 Mental search of concepts is supported by egocentric vector representations and restructured grid maps

Vigano, S.; Bayramova, R.; Doeller, C.; Bottini, R.

10.1101/2023.01.19.524704 — neuroscience — Posted on 2023-01-20

1555 Analysis of skull thickness, scalp-to-cortex distance and association with age and sex in cognitively normal elderly

Zhang, J.; Treyer, V.; Gietl, A.; Sun, J.; Zhang, C.; Hock, C.; Razansky, D.; Nitsch, R. M.; Ni, R.

10.1101/2023.01.19.524484 — neuroscience — Posted on 2023-01-20

1556 Experimental and computational analysis of REM sleep distributed cortical activity in mice

Peuvrier, M.; Fernandez, L.; Crochet, S.; Destexhe, A.; Salin, P.

10.1101/2023.01.19.524685 — neuroscience — Posted on 2023-01-20

1557 Novel genetically encoded tools for imaging or silencing neuropeptide release from presynaptic terminals in vivo

Kim, D.-I.; Park, S.; Ye, M.; Chen, J. Y.; Jhang, J.; Hunker, A. C.; Zweifel, L. S.; Palmiter, R. D.; Han, S.

10.1101/2023.01.19.524797 — neuroscience — Posted on 2023-01-20

1558 Structure of sleep explained by wave mechanics

Kharchenko, V. A.; Zhdanova, I.

10.1101/2023.01.19.524817 — neuroscience — Posted on 2023-01-20

1559 Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area

Lei, H. C.; Parker, K. E.; Yuede, C. M.; McCall, J. G.; Imai, S.-i.

10.1101/2023.01.19.524624 — neuroscience — Posted on 2023-01-20

1560 TCF4 mutations disrupt synaptic function through dysregulation of RIMBP2 in patient-derived cortical neurons

Davis, B. A.; Chen, H.-Y.; Ye, Z.; Ostlund, I.; Tippani, M.; Das, D.; Sripathy, S. R.; Wang, Y.; Martin, J. M.; Shim, G.; Panchwagh, N. M.; Moses, R. L.; Farinelli, F.; Bohlen, J. F.; Li, M.; Luikart, B. W.; Jaffe, A. E.; Maher, B. J.

10.1101/2023.01.19.524788 — neuroscience — Posted on 2023-01-20

1561 Cortex-wide topography of 1/f-exponent in Parkinson's disease

Helson, P.; Lundqvist, D.; Svenningsson, P.; Vinding, M. C.; Kumar, A.

10.1101/2023.01.19.524792 — neuroscience — Posted on 2023-01-20

1562 Wireless in vivo Recording of Cortical Activity by an Ion-Sensitive Field Effect Transistor

Bhatt, S.; Masterson, E.; Zhu, T.; Eizadi, J.; George, J.; Graupe, N.; Vareberg, A.; Phillips, J.; Bok, I.; Dwyer, M.; Ashtiani, A.; Hai, A.

10.1101/2023.01.19.524785 — neuroscience — Posted on 2023-01-20

1563 Spatial transcriptomic brain imaging reveals the effects of immunomodulation therapy upon specific regional brain cells in mouse dementia model

Lee, E. J.; Bae, S.; Suh, M.; Choi, H.; Choi, Y.; Hwang, D. W.; Lee, D. S.

10.1101/2023.01.20.524845 — neuroscience — Posted on 2023-01-20

1564 Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans

Yaakub, S. N.; White, T. A.; Roberts, J.; Verhagen, L.; Stagg, C. J.; Hall, S. D.; Fouragnan, E. F.

10.1101/2023.01.20.524869 — neuroscience — Posted on 2023-01-20

1565 Subtractive adaptation is a more effective and general mechanism in binocular rivalry than divisive adaptation

Cravo, M. I.; Bernardes, R.; Castelo-Branco, M.

10.1101/2023.01.19.524840 — neuroscience — Posted on 2023-01-20

1566 Sleep specific changes in infra-slow and respiratory frequency drivers of cortical EEG rhythms

Väyrynen, T.; Helakari, H.; Korhonen, V.; Tuunanen, J.; Huotari, N.; Piispala, J.; Kallio, M.; Raitamaa, L.; Kananen, J.; Järvelä, M.; Palva, J. M.; Kiviniemi, V.

10.1101/2023.01.20.524831 — neuroscience — Posted on 2023-01-20

1567 Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice

Cavallaro, J.; Yeisley, J.; Akdogan, B.; Floeder, J. R.; Balsam, P. D.; Gallo, E. F.

10.1101/2023.01.20.524596 — neuroscience — Posted on 2023-01-20

1568 Plasticity in the functional properties of NMDA receptors improves motor circuit performance during severe energy stress

Bueschke, N.; Hu, M.; Amaral-Silva, L.; Alvarez, A.; Santin, J. M.

10.1101/2023.01.19.524811 — neuroscience — Posted on 2023-01-20

1569 No trade-off between the use of space and time for working memory

de Vries, E.; Fejer, G.; van Ede, F.

10.1101/2023.01.20.524861 — neuroscience — Posted on 2023-01-20

1570 A systematic mapping of the genomic and proteomic variation associated with monogenic diabetes

Kuznetsova, K.; Vasicek, J.; Skiadopoulou, D.; Molnes, J.; Udler, M.; Johansson, S.; Njolstad, P. R.; Manning, A. K.; Vaudel, M.

10.1101/2023.01.19.524722 — bioinformatics — Posted on 2023-01-20

1571 Identifying equally scoring trees in phylogenomics with incomplete data using Gentrius

Chernomor, O.; Elgert, C.; von Haeseler, A.

10.1101/2023.01.19.524678 — bioinformatics — Posted on 2023-01-20

1572 Effects of Inbreeding on Microbial Community Diversity of Zea mays

Schultz, C. R.; Johnson, M. S.; Wallace, J.

10.1101/2023.01.19.524730 — bioinformatics — Posted on 2023-01-20

1573 GUIFold - A graphical user interface for local AlphaFold2

Kempf, G.; Cavadini, S.

10.1101/2023.01.19.521406 — bioinformatics — Posted on 2023-01-20

1574 Power analysis of cell-type deconvolution methods across tissues

Vathrakokoili Pournara, A.; Miao, Z.; Beker, O. Y.; Brazma, A.; Papatheodorou, I.

10.1101/2023.01.19.523443 — bioinformatics — Posted on 2023-01-20

1575 Acoustically Targeted Noninvasive Gene Therapy in Large Brain Regions

Nouraein, S.; Saenz, V. A.; Del Mundo, H. C.; Yiu, J.; Szablowski, J. O.

10.1101/2023.01.19.524626 — bioengineering — Posted on 2023-01-20

1576 Alanine replacements in the structured C-terminal domain of the prion protein reveal conformationally variable regions as major determinants for prion propagation

Bhamra, S. K.; Arora, P.; Hosszu, L. L. P.; Bieschke, J.; Clarke, A. R.; Collinge, J.; Jat, P.

10.1101/2023.01.19.524767 — biochemistry — Posted on 2023-01-20

1577 Chargaff's second parity rule lies at the origin of additive genetic interactions in quantitative traits to make natural selection possible.

Matkarimov, B. T.; Saparbaev, M. K.

10.1101/2023.01.19.524724 — genomics — Posted on 2023-01-20

1578 Single-cell sequencing for the molecular identity involved in zinc therapy for spinal cord injury

Shi, Z.; Lin, J.; Ge, M.; Hu, H.; Tian, M.; Mao, L.; Tian, H.; Mei, X.

10.1101/2023.01.19.524759 — genomics — Posted on 2023-01-20

1579 Variance component estimates, phenotypic characterization, and genetic evaluation of bovine congestive heart failure in commercial feeder cattle

Buchanan, J. W.; Flagel, L. E.; MacNeil, M. D.; Nilles, A. R.; Hoff, J. L.; Pickrell, J.; Raymond, R. C.

10.1101/2023.01.19.524739 — genetics — Posted on 2023-01-20

1580 Candidate gene length polymorphisms are linked to dispersive behaviour: searching for a mechanism behind the "paradox of the great speciators"

Estandia, A.; Sendell-Price, A. T.; Oatley, G.; Robertson, F.; Potvin, D.; Massaro, M.; Robertson, B. C.; Clegg, S. M.

10.1101/2023.01.19.524190 — evolutionary biology — Posted on 2023-01-20

1581 Interaction between mutation type and gene pleiotropy drives parallel evolution in the laboratory

Ruelens, P.; Wynands, T.; de Visser, A.

10.1101/2023.01.19.524694 — evolutionary biology — Posted on 2023-01-20

1582 The effectiveness of pseudomagic traits in promoting premating isolation

Aubier, T. G.; Bürger, R.; Servedio, M. R.

10.1101/2023.01.19.524751 — evolutionary biology — Posted on 2023-01-20

1583 Long-term methylome changes after experimental seed demethylation and their interaction with recurrent water stress in Erodium cicutarium (Geraniaceae)

Balao, F.; Medrano, M.; Bazaga, P.; Paun, O.; Alonso, C.

10.1101/2023.01.19.524693 — ecology — Posted on 2023-01-20

1584 Fetal exposure to endocrine disrupting-bisphenol A (BPA) alters testicular fatty acid metabolism in the adult offspring: relevance to sperm maturation and quality

Varma, S.; Molangiri, A.; Kona, S. R.; Ibrahim, A.; Duttaroy, A. K.; Basak, S.

10.1101/2023.01.18.524658 — developmental biology — Posted on 2023-01-20

1585 Spatiotemporal reconstruction of the origin and assembly of smooth muscles in the intestinal villus

Sanketi, B. D.; Mantri, M.; Tavallaei, M. A.; Hu, S.; Wang, M. F. Z.; De Valminck, I.; Kurpios, N. A.

10.1101/2023.01.19.523242 — developmental biology — Posted on 2023-01-20

1586 Extracellular matrices of bone marrow stroma regulate cell phenotype and contribute to distinct stromal niches in vivo

Stone, A. P.; Rand, E.; Thornes, G.; Kay, A. G.; Barnes, A. L.; Hitchcock, I. S.; Genever, P.

10.1101/2023.01.19.524473 — cell biology — Posted on 2023-01-20

1587 The catalytic activity of microRNA Argonautes plays a modest role in microRNA star strand cleavage in C. elegans

Kotagama, K.; Grimme, A. L.; Yang, B.; Sakhawala, R.; Yu, G.; McJunkin, K.

10.1101/2023.01.19.524782 — molecular biology — Posted on 2023-01-20

1588 A decade of hidden phytoplasmas unveiled through citizen science

Brochu, A.-S.; Dionne, A.; Fall, M. L.; Perez-Lopez, E.

10.1101/2023.01.19.524422 — microbiology — Posted on 2023-01-20

1589 FcyRIIB is a novel immune checkpoint in the tumor microenvironment limiting activity of Treg-targeting antibodies

Knorr, D. A.; Leidner, R.; Jensen, S.; Meng, R.; Jones, A.; Ballesteros-Merino, C.; Bell, R. B.; Baez, M.; Sprott, D.; Bifulco, C.; Piening, B. D.; Dahan, R.; Fox, B.; Ravetch, J.

10.1101/2023.01.19.522856 — immunology — Posted on 2023-01-20

1590 Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during persistent infection

Zheng, W.; Chang, I.-C.; Limberis, J.; Budzik, J. M.; Zha, B. S.; Howard, Z.; Ernst, J. D.

10.1101/2023.01.19.524758 — immunology — Posted on 2023-01-20

1591 T helper cells exhibit a dynamic and reversible 3'UTR landscape.

Seyres, D.; Gorka, O.; Schmidt, R.; Marone, R.; Zavolan, M.; Jeker, L. T.

10.1101/2023.01.19.523753 — immunology — Posted on 2023-01-20

1592 Experience dependent plasticity of higher visual cortical areas in the mouse

Craddock, R.; Vasalauskaite, A.; Ranson, A.; Sengpiel, F.

10.1101/2023.01.19.524689 — neuroscience — Posted on 2023-01-20

1593 Dissecting unsupervised learning through hidden Markov modelling in electrophysiological data

Masaracchia, L.; Fredes, F.; Woolrich, M. W.; Vidaurre, D.

10.1101/2023.01.19.524547 — neuroscience — Posted on 2023-01-20

1594 Distinct neuroinflammatory signatures exist across genetic and sporadic ALS cohorts

Rifai, O. M.; O'Shaughnessy, J.; Dando, O. R.; Munro, A. F.; Sewell, M. D.; Abrahams, S.; Waldron, F. M.; Sibley, C. R.; Gregory, J. M.

10.1101/2023.01.19.524561 — neuroscience — Posted on 2023-01-20

1595 Identifying nonlinear Functional Connectivity with EEG/MEG using Nonlinear Time-Lagged Multidimensional Pattern Connectivity (nTL-MDPC)

Rahimi, S.; Jackson, R.; Hauk, O.

10.1101/2023.01.19.524690 — neuroscience — Posted on 2023-01-20

1596 The scheduling of adolescence with Netrin-1 and UNC5C

Hoops, D.; Kyne, R. F.; Salameh, S.; Ewing, E.; He, A. T.; Orsini, T.; Durand, A.; Popescu, C.; Zhao, J. M.; Schatz, K. C.; Lin, L.; Carroll, Q. E.; Liu, G.; Paul, M. J.; Flores, C.

10.1101/2023.01.19.521267 — neuroscience — Posted on 2023-01-20

1597 A haptic illusion created by gravity

Opsomer, L.; Delhaye, B.; Theate, V.; Thonnard, J.-L.; Lefevre, P.

10.1101/2023.01.19.524523 — neuroscience — Posted on 2023-01-20

1598 A Generative Model of Memory Construction and Consolidation

Spens, E.; Burgess, N.

10.1101/2023.01.19.524711 — neuroscience — Posted on 2023-01-20

1599 Human skeletal muscle methylome after low carbohydrate energy balanced exercise

Gorski, P. P.; Turner, D. C.; Iraki, J.; Morton, J. P.; Sharples, A. P.; Areta, J. L.

10.1101/2023.01.19.524676 — physiology — Posted on 2023-01-20

1600 Elucidating the combined toxicity of aflatoxin B1 and fumonisin B1 on HepG2 cells based on respirometry and transcriptome analyses

Chen, X.; Abdallah, M. F.; Grootaert, C.; Van Nieuwerburgh, F.; Rajkovic, A.

10.1101/2023.01.19.524737 — pharmacology and toxicology — Posted on 2023-01-20

1601 Disrupted trans-placental thyroid hormone transport in a human model for MCT8 deficiency

Chen, Z.; Leeuwenburgh, S.; Zijderveld, W. F.; Broekhuizen, M.; Tan, L.; Neuman, R. I.; Jongejan, R. M. S.; de Rijke, Y. B.; Reiss, I. K. M.; Danser, A. H. J.; Peeters, R. P.; Meima, M. E.; Visser, W. E.

10.1101/2023.01.19.524727 — pathology — Posted on 2023-01-20

1602 Global Transcriptomics of Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease using PCK rats

Khare, S.; Jiang, L.; Paine Cabrera, D.; Apte, U.; Pritchard, M. T.

10.1101/2023.01.19.524760 — pathology — Posted on 2023-01-20

1603 Profiling extracellular vesicles in circulation enables the early detection of ovarian cancer

Lee, H.; Dinulescu, D. M.; Castro, C. M.; Jo, A.; Green, A.; Medina, J. E.; Iyer, S.; Ohman, A. W.; McCarthy, E. T.; Reinhardt, F.; Gerton, T.; Demehin, D.; Mishra, R.; Kolin, D. L.; Zheng, H.; Crum, C. P.; Weinberg, R. A.; Reuda, B. R.

10.1101/2023.01.19.524549 — cancer biology — Posted on 2023-01-20

1604 Neuronal Activity-Dependent Mechanisms of Small Cell Lung Cancer Progression

Savchuk, S.; Gentry, K.; Wang, W.; Carleton, E.; Yalcin, B.; Liu, Y.; Pavarino, E. C.; LaBelle, J.; Toland, A. M.; Woo, P. J.; Qu, F.; Filbin, M. G.; Krasnow, M. A.; Sabatini, B. L.; Sage, J.; Monje, M.; Venkatesh, H. S.

10.1101/2023.01.19.524430 — cancer biology — Posted on 2023-01-20

1605 Resistance to vincristine in cancerous B-cells by disruption of p53-dependent mitotic surveillance

Rovsing, A. B.; Thomsen, E. A.; Nielsen, I.; Skov, T. W.; Luo, Y.; Dybkaer, K.; Mikkelsen, J. G.

10.1101/2023.01.19.524713 — cancer biology — Posted on 2023-01-20

1606 Propionate reinforces epithelial identity and reduces aggressiveness of non-small cell lung carcinoma via chromatin remodelling

Ramesh, V.; Gollavilli, P. N.; Pinna, L.; Siddiqui, M. A.; Jakobsen, S. T.; Boiteux, E. L.; Olsen, K. E.; Jensen, O. N.; Siersbaek, R.; Somyajit, K.; Ceppi, P.

10.1101/2023.01.19.524677 — cancer biology — Posted on 2023-01-20

1607 DESP: Demixing Cell State Profiles from Dynamic Bulk Molecular Measurements

Youssef, A.; Paul, I.; Crovella, M.; Emili, A.

10.1101/2023.01.19.524460 — bioinformatics — Posted on 2023-01-20

1608 PanPA: generation and alignment of panproteome graphs

Dabbaghie, F.; Srikakulam, S. K.; Marschall, T.; Kalinina, O. V.

10.1101/2023.01.19.524778 — bioinformatics — Posted on 2023-01-20

1609 Rare disease research workflow using multilayer networks elucidates the molecular determinants of severity in Congenital Myasthenic Syndromes

Nunez-Carpintero, I.; O'Connor, E.; Rigau, M.; Bosio, M.; Azuma, Y.; Topf, A.; Thompson, R.; 't Hoen, P. A. C.; Chamova, T.; Tournev, I.; Guergueltcheva, V.; Laurie, S.; Beltran, S.; Capella-Gutierrez, S.; Cirillo, D.; Lochmuller, H.; Valencia, A.

10.1101/2023.01.19.524736 — bioinformatics — Posted on 2023-01-20

1610 Jammed microgel growth medium prepared by flash-solidification of agarose for 3D cell culture and 3D bioprinting

Sreepadmanabh, M.; Ganesh, M.; Bhat, R.; Bhattacharjee, T.

10.1101/2023.01.19.524686 — bioengineering — Posted on 2023-01-20

1611 Honey bee drones are synchronously hyperactive inside the nest

Neubauer, L. C.; Davidson, J. D.; Wild, B.; Dormagen, D. M.; Landgraf, T.; Couzin, I. D.; Smith, M. L.

10.1101/2023.01.19.524638 — animal behavior and cognition — Posted on 2023-01-20

1612 A scalable platform for functional interrogation of peptide hormones in fish

Moses, E.; Harel, I.

10.1101/2023.01.19.524675 — genetics — Posted on 2023-01-20

1613 MUTATIONAL PROFILE ENABLES THE IDENTIFICATION OF A HIGH RISK SUBGROUP IN MYELODYSPLASTIC SYNDROMES WITH ISOLATED TRISOMY 8

Toribio Castello, S. M.; Castano, S.; Villaverde, A.; Such, E.; Arnan, M.; Sole, F.; Diaz Beya, M.; Diez Campelo, M.; del Rey, M.; Gonzalez, T.; Hernandez Rivas, J. M.

10.1101/2023.01.19.524703 — genetics — Posted on 2023-01-20

1614 Latitudinal gradient in avian insectivory: complementary effects of climate, habitat and bird diversity

10.1101/2023.01.19.524212 — ecology — Posted on 2023-01-20

1615 A Scalable Framework for Closed-Loop Neuromodulation with Deep Learning

Gebodh, N.; Miskovic, V.; Laszlo, S.; Datta, A.; Bikson, M.

10.1101/2023.01.18.524615 — neuroscience — Posted on 2023-01-20

1616 Glycoproteome remodelling and granule-specific N-glycosylation accompany neutrophil granulopoiesis

Kawahara, R.; Ugonotti, J.; Chatterjee, S.; Tjondro, H. C.; Loke, I.; Parker, B. L.; Venkatakrishnan, V.; Dieckmann, R.; Sumer-Bayraktar, Z.; Karlsson-Bengtsson, A.; Bylund, J.; Thaysen-Andersen, M.

10.1101/2023.01.18.524318 — systems biology — Posted on 2023-01-20

1617 Cas9-induced nonhomologous recombination in C. elegans

Zdraljevic, S.; Walter-McNeill, L.; Marquez, H.; Kruglyak, L.

10.1101/2023.01.19.524763 — genetics — Posted on 2023-01-20

1618 Task-specific patterns of odorant receptor expression in worker antennae indicates a sensory filter regulating division of labor in ants

Caminer, M. A.; Libbrecht, R.; Majoe, M.; Ho, D. V.; Foitzik, S.

10.1101/2023.01.20.524877 — evolutionary biology — Posted on 2023-01-20

1619 Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2

Feng, Y.; Yuan, M.; Powers, J. M.; Hu, M.; Munt, J. E.; Arunachalam, P. S.; Leist, S. R.; Bellusci, L.; Adams, L. E.; Sundaramurthy, S.; Shirreff, L. M.; Mallory, M. L.; Scooby, T. D.; Moreno, A.; OHagan, D. T.; Kleanthous, H.; Villinger, F. J.; Veesler, D.; King, N. P.; Suthar, M. S.; Khurana, S.; Baric, R. S.; Wilson, I.; Pulendran, B.

10.1101/2023.01.19.524784 — immunology — Posted on 2023-01-20

1620 Microstructural and cellular characterisation of the subchondral trabecular bone in human knee and hip osteoarthritis using synchrotron tomography

Muratovic, D.; Findlay, D. M.; Quinn, M. J.; Quarrington, R. D.; Solomon, L. B.; Atkins, G. J.

10.1101/2023.01.18.524641 — pathology — Posted on 2023-01-20

1621 Evolutionary selection of proteins with two folds

Schafer, J. W.; Porter, L.

10.1101/2023.01.18.524637 — bioinformatics — Posted on 2023-01-20

1622 Ensemble of similarity metrics with a multiview self-organizing map improves cell clustering in highly multiplexed imaging cytometry data.

Willie, E.; Yang, P.; Patrick, E.

10.1101/2023.01.18.524659 — bioinformatics — Posted on 2023-01-20

1623 Both behavior-manipulating and non-manipulating entomopathogenic fungi affect rhythmic gene expression in carpenter ant foragers upon infection

Das, B.; Brachmann, A.; de Bekker, C.

10.1101/2023.01.19.524837 — animal behavior and cognition — Posted on 2023-01-20

1624 Serotonin blocker Ketanserin reduces coral reef fish Ctenochaetus striatus aggressive behaviour during between-species social interactions

Staubli, V.; Bshary, R.; Triki, Z.

10.1101/2023.01.20.524902 — animal behavior and cognition — Posted on 2023-01-20

1625 Targeted Screening and Identification of Chlorhexidine as a Pro-myogenic Circadian Clock Activator

Ma, k.; Kiperman, T.; Li, W.; Xiong, X.; Li, H.; Horne, D.

10.1101/2023.01.18.524648 — developmental biology — Posted on 2023-01-20

1626 piRNA processing by a trimeric Schlafen-domain nuclease

Podvalnaya, N.; Bronkhorst, A. W.; Lichtenberger, R.; Hellmann, S.; Nischwitz, E.; Falk, T.; Karaulanov, E.; Butter, F.; Falk, S.; Ketting, R.

10.1101/2023.01.19.524756 — molecular biology — Posted on 2023-01-20

1627 Induction of SARS-CoV-2 N-specific CD8+ T cell immunity in lungs by engineered extracellular vesicles associates with strongly impaired viral replication

Manfredi, F.; Chiozzini, C.; Ferrantelli, F.; Leone, P.; Pugliese, k.; Spada, M.; Di Virgilio, A.; Giovannelli, A.; Valeri, M.; Cara, A.; Michelini, Z.; Andreotti, M.; Federico, M.

10.1101/2023.01.19.524762 — immunology — Posted on 2023-01-20

1628 Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses

Duan, M.; Nguyen, D. C.; Joyner, C. J.; Saney, C.; Tipton, C.; Andrews, J.; Lonial, S.; Kim, C.; Hentenaar, I.; Kosters, A.; Ghosn, E.; Jackson, A.; Knechtle, S.; Maruthamuthu, S.; Chandran, S.; Martin, T.; Rajalingam, R.; Vincenti, F.; Breeden, C.; Sanz, I.; Gibson, G.; Lee, F. E.-H.

10.1101/2023.01.18.524601 — immunology — Posted on 2023-01-20

1629 Intrathecal Cu-albumin PET reveals age-related decline of cerebrospinal fluid (CSF)-lymphatic efflux

Sarker, A.; Suh, M.; Choi, Y.; Park, J. Y.; Lee, Y.-S.; Lee, D. S.

10.1101/2023.01.18.524645 — neuroscience — Posted on 2023-01-20

1630 Hierarchical Deviant Processing in Auditory Cortex of Awake Mice

Luo, D.; Liu, J.; Auksztulewicz, R.; Yip, T. K.-W.; Kanold, P. O.; Schnupp, J. W. H.

10.1101/2023.01.18.524413 — neuroscience — Posted on 2023-01-20

1631 Post-Ischemic Reorganization of Sensory Responses in Cerebral Cortex

Hayley, P.; Tuchek, C.; Dalla, S.; Borrell, J.; Murphy, M. D.; Nudo, R. J.; Guggenmos, D. J.

10.1101/2023.01.18.524583 — neuroscience — Posted on 2023-01-20

1632 Translational predictions of phase 2a first-in patient efficacy studies for antituberculosis drugs

Savic, R. M.; Goh, J. J. N.; Ernest, J. P.; Strydom, N.; Wang, Q.; van Wijk, R. C.; Zhang, N.; Deitchman, A.; Nuermberger, E.

10.1101/2023.01.18.524608 — pharmacology and toxicology — Posted on 2023-01-20

1633 Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome

Jain, A.; Govindan, R.; Berkman, A.; Luban, J.; Durham, N. D.; Munro, J.

10.1101/2023.01.18.524651 — biophysics — Posted on 2023-01-20

1634 circRNA-sponging: a pipeline for extensive analysis of circRNA expression and their role in miRNA sponging

Hoffmann, M.; Schwartz, L.; Ciora, O.-A.; Trummer, N.; Willruth, L.-L.; Jankowski, J.; Lee, H. K.; Baumbach, J.; Furth, P. A.; Hennighausen, L.; List, M.

10.1101/2023.01.19.524495 — bioinformatics — Posted on 2023-01-20

1635 Functional domain annotation by structural similarity

Mirzavand Borujeni, P.; Salavati, R.

10.1101/2023.01.18.524644 — bioinformatics — Posted on 2023-01-20

1636 Phantom controllers: Misspecified models create the false appearance of adaptive control during value-based choice

Ritz, H.; Frömer, R.; Shenhav, A.

10.1101/2023.01.18.524640 — animal behavior and cognition — Posted on 2023-01-20

1637 Sex chromosome evolution in beetles

Bracewell, R.; Tran, A.; Chatla, K.; Bachtrog, D.

10.1101/2023.01.18.524646 — evolutionary biology — Posted on 2023-01-20

1638 Neuro-immune modulation of cholinergic signaling in an addiction vulnerability trait

Carmon, H.; Haley, E. C.; Parikh, V.; Tronson, N. C.; Sarter, M.

10.1101/2022.12.05.519158 — neuroscience — Posted on 2023-01-20

1639 lmeEEG: Mass linear mixed-effects modeling of EEG data with crossed random effects

Visalli, A.; Montefinese, M.; Viviani, G.; Finos, L.; Vallesi, A.; Ambrosini, E.

10.1101/2023.01.18.524560 — neuroscience — Posted on 2023-01-20

1640 Mechanistic Basis for Enhanced Strigolactone Sensitivity in KAI2 Triple Mutant

Sobecks, B. L.; Chen, J.; Shukla, D.

10.1101/2023.01.18.524622 — plant biology — Posted on 2023-01-20

1641 Effect of soilless media on small-scale propagation of Pinguicula gigantea

Tarner, K.; Jones, H.; Gaya, H.; Ingwers, M.; McNair, M. C.

10.1101/2023.01.18.523674 — plant biology — Posted on 2023-01-20

1642 Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration

Raslan, A. A.; Pham, T. X.; Lee, J.; Hong, J.; Schmottlach, J. K.; Nicolas, K.; Taha, M. D.; Bujor, A. M.; Caporarello, N.; Thiriot, A.; von Andrian, U. H.; Huang, S. K.; Nicosia, R. F.; Trojanowska, M.; Varelas, X.; Ligresti, G.

10.1101/2023.01.17.523179 — pathology — Posted on 2023-01-20

1643 Tipifarnib potentiates the antitumor effects of PI3Kα inhibition in PIK3CA- and HRAS-dysregulated HNSCC via convergent inhibition of mTOR activity

Smith, A. E.; Chan, S.; Wang, Z.; McCloskey, A.; Reilly, Q.; Wang, J. Z.; Patel, H. V.; Koshizuka, K.; Soifer, H. S.; Kessler, L.; Dayoub, A.; Villaflor, V.; Adkins, D.; Bruce, J. Y.; Ho, A.; Perez, C. A.; Hanna, G. J.; Gasco Hernandez, A.; Saunders, A.; Dale, S.; Gutkind, J. S.; Burrows, F.; Malik, S.

10.1101/2023.01.17.523964 — cancer biology — Posted on 2023-01-20

1644 Differential occupancy and regulatory interactions of KDM6A in bladder cell lines

Ozden-Yilmaz, G.; Savas, B.; Bursali, A.; Eray, A.; Aribas, A.; Senturk, S.; Karaca, E.; Karakulah, G.; Erkek-Ozhan, S.

10.1101/2022.12.19.520968 — cancer biology — Posted on 2023-01-20

1645 Tipifarnib potentiates the antitumor effects of PI3Kα inhibition in PIK3CA- and HRAS-dysregulated HNSCC via convergent inhibition of mTOR activity

10.1101/2023.01.17.523964 — cancer biology — Posted on 2023-01-20

1646 Fast and robust metagenomic sequence comparison through sparse chaining with skani

Shaw, J.; Yu, Y. W.

10.1101/2023.01.18.524587 — bioinformatics — Posted on 2023-01-20

1647 Radiances of Cerenkov-Emitting Isotopes on the IVIS

Pratt, E. C.; Shaffer, T. M.; Bauer, D.; Lewis, J. S.; Grimm, J.

10.1101/2023.01.18.524625 — bioengineering — Posted on 2023-01-20

1648 Defining T cell receptor repertoires using nanovial-based affinity and functional screening

Koo, D.; Mao, Z.; Dimatteo, R.; Tsubamoto, N.; Noguchi, M.; McLaughlin, J.; Tran, W.; Lee, S.; Cheng, D.; de Rutte, J.; Burton Sojo, G.; Witte, O.; Di Carlo, D.

10.1101/2023.01.17.524440 — bioengineering — Posted on 2023-01-20

1649 Trial-history biases in evidence accumulation can give rise to apparent lapses

Gupta, D.; DePasquale, B.; Kopec, C. D.; Brody, C.

10.1101/2023.01.18.524599 — animal behavior and cognition — Posted on 2023-01-20

1650 Recursive Prefix-Free Parsing for Building Big BWTs

Oliva, M.; Gagie, T.; Boucher, C.

10.1101/2023.01.18.524557 — genomics — Posted on 2023-01-20

1651 Dating in the Dark: Elevated Substitution Rates in Cave Cockroaches (Blattodea: Nocticolidae) Have Negative Impacts on Molecular Date Estimates

Kovacs, T. G. L.; Walker, J.; Hellemans, S.; Bourguignon, T.; Tatarnic, N. J.; McRae, J. M.; Ho, S. Y. H.; Lo, N.

10.1101/2023.01.17.524483 — evolutionary biology — Posted on 2023-01-20

1652 The prevalence of dementia in humans could be the result of a functional adaptation

Holt, A. G.; Davies, A. M.

10.1101/2023.01.17.524364 — evolutionary biology — Posted on 2023-01-20

1653 The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling

Carlantoni, C.; Liekfeld, L.; Hemkemeyer, S. A.; Schreier, D.; Saygi, C.; Kurelic, R.; Cardarelli, S.; Kalucka, J.; Schulte, C.; Beerens, M.; Mailer, R.; Schaeffer, T.; Naro, F.; Pellegrini, M.; Nikolaev, V.; Renne, T.; Frye, M.

10.1101/2023.01.18.524585 — developmental biology — Posted on 2023-01-20

1654 Dynamic Effects of Ventral Hippocampal NRG3/ERBB4 Signaling on Nicotine Withdrawal-Induced Responses

Fisher, M. L.; Prantzalos, E.; O'Donovan, B.; Anderson, T.; Sahoo, P. K.; Twiss, J. L.; Ortinski, P. I.; Turner, J. R.

10.1101/2023.01.17.524432 — neuroscience — Posted on 2023-01-20

1655 Frontotemporal Dementia Patient Neurons With Progranulin Deficiency Display Protein Dyshomeostasis

Elia, L. P.; Herting, B.; Alijagic, A.; Buselli, C.; Wong, L.; Morrison, G.; Prado, M. A.; Paolo, J. A.; Gygi, S.; Finley, D.; Finkbeiner, S.

10.1101/2023.01.18.524611 — neuroscience — Posted on 2023-01-20

1656 Measurable fields to spikes causality and its dependence on cortical layer and area.

Akella, S.; Bastos, A. M.; Miller, E. K.; Principe, J. C.

10.1101/2023.01.17.524451 — neuroscience — Posted on 2023-01-20

1657 Dynamic fluctuations in ascending heart-to-brain modulations under mental stress elicitation

Candia-Rivera, D.; Norouzi, K.; Ramsoy, T. Z.; Valenza, G.

10.1101/2022.09.09.507362 — neuroscience — Posted on 2023-01-20

1658 Brain Oscillations during Visuomotor Processing in Children with ASD

Wilson, E. M.; An, K.-M.

10.1101/2023.01.17.524474 — neuroscience — Posted on 2023-01-20

1659 Reliability of decision-making and reinforcement learning computational parameters

Mkrtchian, A.; Valton, V.; Roiser, J. P.

10.1101/2021.06.30.450026 — neuroscience — Posted on 2023-01-20

1660 Distinct Neural Signatures of Multimodal Resizing Illusions: Implications for Chronic Pain Treatment

Hansford, K. J.; Baker, D. H.; McKenzie, K. J.; Preston, C. E. J.

10.1101/2023.01.18.524558 — neuroscience — Posted on 2023-01-20

1661 sLASER and PRESS Perform Similarly at Revealing Metabolite-Age Correlations

Hui, S. C. N.; Gong, T.; Zoellner, H. J.; Hupfeld, K. E.; Gudmundson, A.; Murali-Manohar, S.; Davies-Jenkins, C.; Song, Y.; Chen, Y.; Oeltzschner, G.; Wang, G.; Edden, R. A. E.

10.1101/2023.01.18.524597 — neuroscience — Posted on 2023-01-20

1662 AUTOMATIC EXTRACTION OF ACTIN NETWORKS IN PLANTS

Hembrow, J.; Richards, D. M.; Deeks, M. J.

10.1101/2023.01.18.524528 — plant biology — Posted on 2023-01-20

1663 Inducible TRAP RNA profiling reveals host genes expressed in Arabidopsis cells haustoriated by downy mildew

Asai, S.; Cevik, V.; Jones, J. D. G.; Shirasu, K.

10.1101/2023.01.17.524393 — plant biology — Posted on 2023-01-20

1664 Sas3-mediated histone acetylation regulates effector gene activation in a fungal plant pathogen

Suarez-Fernandez, M.; Alvarez-Aragon, R.; Pastor-Mediavilla, A.; Maestre-Guillen, A.; del Olmo, I.; de Francesco, A.; Meile, L.; Sanchez-Vallet, A.

10.1101/2023.01.18.524538 — plant biology — Posted on 2023-01-20

1665 Cyclic and pseudo-cyclic electron pathways play antagonistic roles during nitrogen deficiency in Chlamydomonas reinhardtii

Dao, O.; Burlacot, A.; Huleux, M.; Auroy, P.; Peltier, G.; Li-Beisson, Y.

10.1101/2023.01.18.524499 — plant biology — Posted on 2023-01-20

1666 The complete chloroplast genome sequence of Akebia trifoliata and a comparative analysis within the Ranales clade

Wang, R.; Chu, Q.; Meng, G.; Li, C.

10.1101/2023.01.18.524534 — plant biology — Posted on 2023-01-20

1667 A predicted amphipathic helix contributes to the efficient S-acylation of the Arabidopsis thaliana Calcineurin B-like protein 2

Wyganowski, T.; Beckmann, L.; Batistic, O.

10.1101/2023.01.17.524453 — plant biology — Posted on 2023-01-20

1668 CONSTANS alters the circadian clock in Arabidopsis thaliana

de los Reyes, P.; Romero-Campero, F. J.; Gao, H.; Serrano-Bueno, G.; Romero, J. M.; Valverde, F.

10.1101/2023.01.19.524697 — plant biology — Posted on 2023-01-20

1669 C-terminal conformational changes in SCF-D3/MAX2 ubiquitin ligase are required for KAI2-mediated signaling

Tal, L.; Guercio, A. M.; Varshney, K.; Young, A.; Gutjahr, C.; Shabek, N.

10.1101/2023.01.19.524830 — plant biology — Posted on 2023-01-20

1670 Competing differentiation gradients coordinate fruit morphogenesis

Gomez-Felipe, A.; Marconi, M.; Branchini, E.; Wang, B.; Bertrand-Rakusova, H.; Stan, T.; Burkiewicz, J.; de Folter, S.; Routier-Kierzkowska, A.-L.; Wabnik, K.; Kierzkowski, D.

10.1101/2023.01.19.524793 — plant biology — Posted on 2023-01-20

1671 Lhcb9-dependent photosystem I structure in moss reveals evolutionary adaptation to changing light conditions during aquatic-terrestrial transition

Sun, H.; Shang, H.; Pan, X.; Li, M.

10.1101/2023.01.18.524345 — plant biology — Posted on 2023-01-20

1672 Glutathione transferase photoaffinity labeling demonstrates GST activation by safeners and NPR1-independent activation by BTH

Font Farre, M.; Brown, D.; Koning, M.; Killinger, B. J.; Kaschani, F.; Kaiser, M.; Wright, A. T.; Burton, J.; van der Hoorn, R. A. L.

10.1101/2023.01.19.524829 — plant biology — Posted on 2023-01-20

1673 Downregulation and delayed induction of photosynthesis by coordinated transcriptomic changes induced by sink-source imbalance

Ozawa, Y.; Tanaka, A.; Suzuki, T.; Sugiura, D.

10.1101/2023.01.19.524789 — plant biology — Posted on 2023-01-20

1674 Transcriptome analysis of Medicago truncatula Autoregulation of Nodulation mutants reveals that disruption of the SUNN pathway causes constitutive expression changes in a small group of genes, but the overall response to rhizobia resembles wild type, including induction of TML1 and TML2.

Schnabel, E.; Chavan, S.; Poehlman, W.; Feltus, F. A.; Frugoli, J.

10.1101/2023.01.19.524769 — plant biology — Posted on 2023-01-20

1675 S-acylation stabilizes ligand-induced receptor kinase complex formation during plant pattern-triggered immune signalling.

Hurst, C. H.; Turnbull, D.; Xhelilaj, K.; Myles, S.; Pflughaupt, R. L.; Kopischke, M.; Davies, P.; Jones, S.; Robatzek, S.; Zipfel, C.; Gronnier, J.; Hemsley, P.

10.1101/2021.08.30.457756 — plant biology — Posted on 2023-01-20

1676 Depletion of the NbCORE receptor drastically improves agroinfiltration productivity in older Nicotiana benthamiana plants.

Dodds, I.; Chen, C.; Buscaill, P.; van der Hoorn, R. A. L.

10.1101/2023.01.18.517935 — plant biology — Posted on 2023-01-20

1677 Nitrogen-limitation independent control of glnA (glutamine synthetase) expression in Escherichia coli by urea, several amino acids, and post-transcriptional regulation.

Urs, K.; Zimmern, P. E.; Reitzer, L.

10.1101/2023.01.17.524496 — physiology — Posted on 2023-01-20

1678 Nanovirseq: dsRNA sequencing for plant virus and viroid detection by Nanopore sequencing

J. Javaran, V.; Poursalavati, A.; Lemoyne, P.; Ste-Croix, D. T.; Moffett, P.; Fall, M. L.

10.1101/2023.01.18.524564 — pathology — Posted on 2023-01-20

1679 Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states

Nyman, J.; Denize, T.; Bakouny, Z.; Labaki, C.; Titchen, B. M.; Bi, K.; Hari, S. N.; Rosenthal, J.; Mehta, N.; Jiang, B.; Sharma, B.; Felt, K.; Umeton, R.; Braun, D. A.; Rodig, S.; Chouieri, T. K.; Signoretti, S.; Van Allen, E. M.

10.1101/2023.01.18.524545 — cancer biology — Posted on 2023-01-20

1680 Stochastic motion and transcriptional dynamicsof distal enhancer-promoter pairs on a compacted chromosome

Brueckner, D. B.; Chen, H.; Barinov, L.; Zoller, B.; Gregor, T.

10.1101/2023.01.18.524527 — biophysics — Posted on 2023-01-20

1681 Optimal Cellular Phenotypic Adaptation in Fluctuating Environments

George, J. T.

10.1101/2023.01.17.524479 — biophysics — Posted on 2023-01-20

1682 Emergent Simplicities in Stochastic Intergenerational Homeostasis

Joshi, K.; Wright, C. S.; Ziegler, K. F.; Spiers, E. M.; Crosser, J. T.; Eschker, S.; Biswas, R. R.; Iyer-Biswas, S.

10.1101/2023.01.18.524627 — biophysics — Posted on 2023-01-20

1683 Decoding Single-Cell Multiomics: scMaui - A Deep Learning Framework for Uncovering Cellular Heterogeneity in Presence of Batch Effects and Missing Data

Jeong, Y.; Ronen, J.; Kopp, W.; Lutsik, P.; Akalin, A.

10.1101/2023.01.18.524506 — bioinformatics — Posted on 2023-01-20

1684 HiCLift: A fast and efficient tool for converting chromatin interaction data between genome assemblies

Wang, X.; Yue, F.

10.1101/2023.01.17.524475 — bioinformatics — Posted on 2023-01-20

1685 Single-cell RNA sequencing reveals aortic cellular heterogeneity in MSC_ITGB3-treated ApoE-/- mice on a high-fat diet

Hu, H.; Liu, D.; Geng, X.; Han, M.; Cui, W.

10.1101/2023.01.18.524536 — bioinformatics — Posted on 2023-01-20

1686 Implantable flexible multielectrode arrays for multi-site sensing of serotonin tonic levels

Castagnola, E.; Robbins, E. M.; Krahe, D.; Wu, B.; Pwint, M. Y.; Cao, Q.; Cui, X. T.

10.1101/2023.01.17.524488 — bioengineering — Posted on 2023-01-20

1687 Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming

Sterling, M.; Englitz, B.

10.1101/2023.01.18.524540 — animal behavior and cognition — Posted on 2023-01-20

1688 Amplitude modulation pattern of rat distress vocalisations during fear conditioning

Gonzalez-Palomares, E.; Boulanger-Bertolus, J.; Dupin, M.; Mouly, A.-M.; Hechavarria, J. C.

10.1101/2023.01.18.524509 — animal behavior and cognition — Posted on 2023-01-20

1689 Simple Causal Relationships in Gene Expression Discovered through Deep Learned Collective Variables

Wang, C.-H.; Vetsigian, K.; Lin, C.; Firth, F.; Bradley, G.; Granovsky, L.; England, J. L.

10.1101/2023.01.18.524617 — genomics — Posted on 2023-01-20

1690 Caffeine-tolerant mutations selected through an at-home yeast experimental evolution teaching lab

Moresi, N. G.; Geck, R. C.; Skophammer, R.; Godin, D.; yEvo Students, ; Taylor, M. B.; Dunham, M. J.

10.1101/2023.01.17.524437 — genetics — Posted on 2023-01-20

1691 Comparative phylogeography of Ponto-Caspian amphipods throughout the invaded Baltic and native NW Black Sea donor ranges. Can introduction mode affect genetic diversity?

Copilas-Ciocianu, D.; Sidagyte-Copilas, E.; Son, M. O.; Morhun, H.; Macher, J.-N.; Arbaciauskas, K.

10.1101/2023.01.18.524525 — evolutionary biology — Posted on 2023-01-20

1692 Hyperparasitism and the evolution of parasite virulence

Wood, J. R.; Ashby, B.

10.1101/2023.01.18.524570 — evolutionary biology — Posted on 2023-01-20

1693 Extrinsic mortality and senescence: a guide for the perplexed

de Vries, C.; Galipaud, M.; Kokko, H.

10.1101/2022.01.27.478060 — evolutionary biology — Posted on 2023-01-20

1694 Evolution of two gene networks underlying adaptation to drought stress in the wild tomato Solanum chilense

Wei, K.; Sharifova, S.; Sinha, N. R.; Nakayama, H.; Tellier, A.; Silva Arias, G. A.

10.1101/2023.01.18.524537 — evolutionary biology — Posted on 2023-01-20

1695 Limits to the spread of an obligate social cheater in the social amoeba Dictyostelium discoideum

Medina, J. M.; Queller, D.; Strassmann, J. E.

10.1101/2023.01.17.524501 — evolutionary biology — Posted on 2023-01-20

1696 Breakdown in seasonal dynamics of ant communities with land-cover change

Kass, J. M.; Yoshimura, M.; Ogasawara, M.; Suwabe, M.; Hita Garcia, F.; Dudley, K. L.; Donohue, I.; Economo, E. P.

10.1101/2023.01.17.523860 — ecology — Posted on 2023-01-20

1697 Lagrangian Formalism in Biology: II. Non-Standard and Null Lagrangians for Nonlinear Dynamical Systems and their Role in Population Dynamics

Pham, D. T.; Musielak, Z. E.

10.1101/2023.01.18.524517 — ecology — Posted on 2023-01-20

1698 Near-surface wind variability over spatiotemporal scales relevant to plume tracking insects

Houle, J.; van Breugel, F.

10.1101/2023.01.18.524580 — ecology — Posted on 2023-01-20

1699 More than germ cells: vascular development in the early zebrafish (Danio rerio) gonad

Kossack, M. E.; Tian, L.; Bowie, K.; Plavicki, J. E.

10.1101/2023.01.18.524593 — developmental biology — Posted on 2023-01-20

1700 Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics

Unterweger, I.; Klepstad, J.; Hannezo, E.; Lundegaard, P. R.; Trusina, A.; Ober, E. A.

10.1101/2023.01.18.524321 — developmental biology — Posted on 2023-01-20

1701 Determinants of renin cell differentiation: a single cell epi-transcriptomics approach

Martini, A. G.; Smith, J. P.; Medrano, S.; Sheffield, N. C.; Sequeira-Lopez, M. L. S.; Gomez, R. A.

10.1101/2023.01.18.524595 — developmental biology — Posted on 2023-01-20

1702 A Clock and Wavefront Self-Organizing model explains somitogenesis in vivo and in vitro

Klepstad, J.; Marcon, L.

10.1101/2023.01.18.524516 — developmental biology — Posted on 2023-01-20

1703 Mixed Lineage Leukemia (Mll1) establishes global histone H3K4 trimethylation and stem like memory Cd8 T cell formation

Getzler, A. J.; Frederick, M. A.; Diao, H.; Milner, J. J.; Belanger, S.; Chen, R.; Tsuda, S. M.; Albao, D.; Kim, J.; Crotty, S.; Goldrath, A.; Pipkin, M. E.

10.1101/2023.01.18.524461 — immunology — Posted on 2023-01-20

1704 Immune-mediated tumor control in the 5TGM1 transfer model of multiple myeloma

Kellermayer, Z.; Tahri, S.; De Jong, M. M. E.; Papazian, N.; Fokkema, C.; Hoogenboezem, R.; Sanders, M. A.; Boon, L.; Den Hollander, C.; Broijl, A.; Sonneveld, P.; Cupedo, T.

10.1101/2023.01.18.524505 — immunology — Posted on 2023-01-20

1705 Informing generative replay for continual learning with long-term memory formation in the fruit fly

Robinson, B. S.; Joyce, J.; Norman-Tenazas, R.; Vallabha, G. K.; Johnson, E. C.

10.1101/2023.01.18.524467 — neuroscience — Posted on 2023-01-20

1706 Towards reproducible models of sequence learning: replication and analysis of a modular spiking network with reward-based learning

Zajzon, B.; Duarte, R.; Morrison, A.

10.1101/2023.01.18.524604 — neuroscience — Posted on 2023-01-20

1707 Proteomics of the astrocyte secretome reveals changes in their response to soluble oligomeric Abeta

Matafora, V.; Gorb, A.; Noble, W.; Bachi, A.; Perez-Nievas, B. G.; Jimenez-Sanchez, M.

10.1101/2023.01.18.523916 — neuroscience — Posted on 2023-01-20

1708 Effects of Dopamine Receptor Antagonists and Radiation on Mouse Neural Stem/Progenitor Cells

He, L.; Bhat, K.; Ioannidis, A.; Pajonk, F.

10.1101/2023.01.18.524632 — neuroscience — Posted on 2023-01-20

1709 Postinspiratory complex acts as a gating mechanism regulating swallow-breathing coordination and other laryngeal behaviors

Huff, A. D.; Amarante, M. K.; Oliveira, L. M.; Ramirez, J.-M.

10.1101/2023.01.18.524513 — neuroscience — Posted on 2023-01-20

1710 Predictors of sensorimotor adaption: insights from over 100,000 reaches

Tsay, J.; Asmerian, H.; Germine, L.; Wilmer, J.; Ivry, R. B.; Nakayama, K.

10.1101/2023.01.18.524634 — neuroscience — Posted on 2023-01-20

1711 Dendritic morphology affects the neuronal excitability type and the network state

Gowers, R.; Schreiber, S.

10.1101/2022.12.13.520117 — neuroscience — Posted on 2023-01-20

1712 The effects of excess salt intake on the kidney metabolism in Sprague-Dawley rats

Shimada, S.; Hoffmann, B. R.; Yang, C.; Kurth, T.; Greene, A. S.; Liang, M.; Dash, R. K.; Cowley, A. W.

10.1101/2023.01.18.524636 — physiology — Posted on 2023-01-20

1713 Hepatocyte-specific miR-33 deletion attenuates NAFLD-NASH-HCC progression

FERNANDEZ TUSSY, P.; Sun, J.; Cardelo, M. P.; Price, N. L.; Goedeke, L.; Xirouchaki, C. E.; Yang, X.; Pastor-Rojo, O.; Bennett, A. M.; Tiganis, T.; Suarez, Y.; Fernandez-Hernando, C.

10.1101/2023.01.18.523503 — physiology — Posted on 2023-01-20

1714 "Tumor Treating Fields" delivered via electromagnetic induction have varied effects across glioma cell lines and electric field amplitudes

Ravin, R.; Cai, T. X.; Li, A.; Briceno, N.; Pursley, R. H.; Cedillos, M.-G.; Pohida, T.; Wang, H.; Zhuang, Z.; Cui, J.; Morgan, N. Y.; Williamson, N. H.; Gilbert, M. R.; Basser, P. J.

10.1101/2023.01.18.524504 — cancer biology — Posted on 2023-01-20

1715 Targeting PPT1 with ezurpimtrostat sensitives liver tumor to immunotherapy by switching cold into hot microenvironments

Bestion, E.; Rachid, M.; Tijeras-Raballand, A.; Roth, G.; Decaens, T.; Ansaldi, C.; MEZOUAR, S.; Raymond, E.; Halfon, P.

10.1101/2023.01.18.524541 — cancer biology — Posted on 2023-01-20

1716 Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model

Pfefferkorn, R. M.; Mortzfeld, B. M.; Fink, C.; von Frieling, J.; Bossen, J.; Esser, D.; Kaleta, C. M.; Rosenstiel, P.; Heine, H.; Roeder, T.

10.1101/2023.01.18.524563 — cancer biology — Posted on 2023-01-20

1717 Super-enhancer driven expression of BAHCC1 promotes melanomacell proliferation and genome stability

Berico, P.; Nogaret, M.; Gambi, G.; Davidson, G.; Cigrang, M.; Vokshi, B.; Le Gras, S.; Mengus, G.; Ye, T.; Dalmasso, M.; Compe, E.; Bertolotto, C.; Davidson, I.; Coin, F.

10.1101/2023.01.18.524519 — cancer biology — Posted on 2023-01-20

1718 A mathematical model for axonal transport of large cargo vesicles

Rahman, N.; Oelz, D. B.

10.1101/2023.01.18.524542 — biophysics — Posted on 2023-01-20

1719 Morphology as indicator of adaptive changes of model tissues in osmotically and chemically changing environments

Höllring, K.; Vurnek, D.; Gehrer, S.; Dudziak, D.; Hubert, M.; Smith, A.-S.

10.1101/2023.01.18.524301 — biophysics — Posted on 2023-01-20

1720 Uncovering hidden biological processes by probabilistic filtering of single-cell data

Piran, Z.; Nitzan, M.

10.1101/2023.01.18.524512 — bioinformatics — Posted on 2023-01-20

1721 Cracking the black box of deep sequence-based protein-protein interaction prediction

Bernett, J.; Blumenthal, D. B.; List, M.

10.1101/2023.01.18.524543 — bioinformatics — Posted on 2023-01-20

1722 A robust normalized local filter to estimate occupancy directly from cryo-EM maps

Forsberg, B. O.; Shah, P. N. M.; Burt, A.

10.1101/2023.01.18.524529 — bioinformatics — Posted on 2023-01-20

1723 Genome assembly of the hybrid grapevine Vitis Chambourcin

Patel, S.; Harris, Z. N.; Londo, J.; Miller, A.; Fennell, A.

10.1101/2023.01.18.524616 — bioinformatics — Posted on 2023-01-20

1724 Genome wide clustering on integrated chromatin states and Micro-C contacts reveals chromatin interaction signatures

Sexton, C. E.; Han, M. V.

10.1101/2023.01.18.524458 — bioinformatics — Posted on 2023-01-20

1725 Combining protein sequences and structures with transformers and equivariant graph neural networks to predict protein function

Boadu, F.; Cao, H.; Cheng, J.

10.1101/2023.01.17.524477 — bioinformatics — Posted on 2023-01-20

1726 Characterizing Primary transcriptional responses to short term heat shock in paired fraternal lymphoblastoid lines with and without Down syndrome.

Cardiello, J. F.; Westfall, J.; Dowell, R. D.; Allen, M. A.

10.1101/2023.01.17.524431 — bioinformatics — Posted on 2023-01-20

1727 A method for predicting linear and conformational B-cell epitopes in an antigen from its primary sequence

Kumar, N.; Tripathi, S.; Sharma, N.; Patiyal, S.; Devi, N. L.; Raghava, G. P. S.

10.1101/2023.01.18.524531 — bioinformatics — Posted on 2023-01-20

1728 Decoupling the correlation between cytotoxic and exhausted T lymphocyte transcriptomic signatures enhances melanoma immunotherapy response prediction

Wang, B.; Wang, K.; Jiang, P.; Ruppin, E.; Wang, B.

10.1101/2023.01.17.524482 — bioinformatics — Posted on 2023-01-20

1729 Predicting tumor immune microenvironment and checkpoint therapy response of head & neck cancer patients from blood immune single-cell transcriptomics

Cao, Y.; Chang, T.; Schischlik, F.; Wang, K.; Sinha, S.; Hannenhalli, S.; Jiang, P.; Ruppin, E.

10.1101/2023.01.17.524455 — bioinformatics — Posted on 2023-01-20

1730 LRphase: an efficient method for assigning haplotype identity to long reads

Holmes, M. J.; Mahjour, B.; Castro, C. P.; Farnum, G. A.; Diehl, A. G.; Boyle, A. P.

10.1101/2023.01.18.524565 — bioinformatics — Posted on 2023-01-20

1731 Approximations to the solution of the Kushner-Stratonovich equation for the stochastic chemostat

Fontenele Magalhaes, J. A.; Emzir, M. F.; Corona, F.

10.1101/2023.01.17.524503 — bioengineering — Posted on 2023-01-20

1732 Method for assessing coating uniformity of angioplasty balloons coated with poly(lactic-co-glycolic acid) nanoparticles loaded with quercetin

Zieschang, A. D.; Hoffseth, K.; Dugas, T. R.; Astete, C.; Boldor, D.

10.1101/2023.01.18.524614 — bioengineering — Posted on 2023-01-20

1733 Towards development of serum substitute medium to induce osteoclast differentiation of human peripheral blood derived monocytes

Ansari, S.; Ito, K.; Hofmann, S.

10.1101/2023.01.18.524526 — bioengineering — Posted on 2023-01-20

1734 Vision-Based Collective Motion: A Locust-Inspired Reductionist Model

Krongauz, D. L.; Ayali, A.; Kaminka, G. A.

10.1101/2023.01.17.524210 — animal behavior and cognition — Posted on 2023-01-20

1735 Combinatorial single-cell profiling of all major chromatin types with MAbID

Lochs, S. J. A.; van der Weide, R. H.; de Luca, K. L.; Korthout, T.; van Beek, R. E.; Kimura, H. J. A.; Kind, J.

10.1101/2023.01.18.524584 — genomics — Posted on 2023-01-20

1736 The evolution of the gliotoxin biosynthetic gene cluster in Penicillium fungi

Balamurugan, C.; Steenwyk, J. L.; Goldman, G. H.; Rokas, A.

10.1101/2023.01.17.524442 — evolutionary biology — Posted on 2023-01-20

1737 Variation in temperature of peak trait performance will constrain adaptation of arthropod populations to climatic warming.

Pawar, S.; Huxley, P.; Smallwood, T.; Nesbit, M.; Chan, A.; Shocket, M.; Johnson, L. R.; Kontopoulos, D. - G.; Cator, L.

10.1101/2023.01.18.524448 — ecology — Posted on 2023-01-20

1738 Metacognitive Judgments during Visuomotor Learning Reflect the Integration of Error History

Hewitson, C. L.; McDougle, S.; Al-Fawakhiri, N.

10.1101/2023.01.17.524436 — neuroscience — Posted on 2023-01-20

1739 Impact of carbon monoxide on neural activation during a reaction time task

Wilson, L. A.; Herigstad, M.

10.1101/2023.01.17.524443 — neuroscience — Posted on 2023-01-20

1740 Comparison of wholemount dissection methods for neuronal subtype marker expression in the mouse myenteric plexus

Gomez-Frittelli, J.; Hamnett, R.; Kaltschmidt, J. A.

10.1101/2023.01.17.524014 — neuroscience — Posted on 2023-01-20

1741 Specific and non-linear effects of glaucoma on optic radiation tissue properties

Kruper, J.; Richie-Halford, A. C.; Benson, N. C.; Caffarra, S.; Owen, J. P.; Wu, Y.; Lee, A. Y.; Lee, C. S.; Yeatman, J. D.; Rokem, A.

10.1101/2023.01.17.524459 — neuroscience — Posted on 2023-01-20

1742 Towards stability of dynamic FC estimates in neuroimaging and electrophysiology: solutions and limits

Alonso, S.; Vidaurre, D.

10.1101/2023.01.18.524539 — neuroscience — Posted on 2023-01-20

1743 Identifying Neural Signatures of Dopamine Signaling with Machine Learning

Sorooshyari, S.; Ouassil, N.; Yang, S. J.; Landry, M. P.

10.1101/2023.01.17.524454 — neuroscience — Posted on 2023-01-20

1744 Rice WRKY13 TF protein binds to motifs in the promoter region to regulate downstream disease resistance-related genes

Jimmy, J. L.; Karn, R.; Kumari, S.; Sruthilaxmi, C. B.; Pooja, S.; Babu, S.

10.1101/2023.01.18.523945 — plant biology — Posted on 2023-01-20

1745 Secure Deep Learning on Genomics Data via a Homomorphic Encrypted Residue Activation Network

Song, C.; Shi, X.

10.1101/2023.01.16.524344 — bioinformatics — Posted on 2023-01-20

1746 The nuclear to cytoplasmic ratio drives cellularization in the close animal relative Sphaeroforma arctica

Olivetta, M.; Dudin, O.

10.1101/2023.01.19.524795 — evolutionary biology — Posted on 2023-01-20

1747 Andes virus genome mutations that are likely associated with animal-model attenuation and human person-to-person transmission

Bellomo, C.; Alonso, D.; Perez-Sautu, U.; Prieto, K.; Kehl, S.; Coelho, R.; Periolo, N.; Di Paola, N.; Ferressini-Gerpe, N.; Kuhn, J. H.; Sanchez-Lockhart, M.; Palacios, G. F.; Martinez, V.

10.1101/2023.01.18.524667 — microbiology — Posted on 2023-01-20

1748 Hierarchical Bayesian modeling identifies key considerations in the development of quantitative loop-mediated isothermal amplification assays

Bradley, J. R.; Borges, D.; Cavaleiro, M.; Mayhew, M. B.

10.1101/2023.01.16.524143 — bioinformatics — Posted on 2023-01-20

1749 Parental care maintains genetic variation by relaxing selection

Pascoal, S.; Shimadzu, H.; Mashoodh, R.; Kilner, R.

10.1101/2022.05.05.490718 — evolutionary biology — Posted on 2023-01-20

1750 How microscopic epistasis and clonal interference shape the fitness trajectory in a spin glass model of microbial long-term evolution

Boffi, N. M.; Guo, Y.; Rycroft, C. H.; Amir, A.

10.1101/2023.01.16.524306 — evolutionary biology — Posted on 2023-01-20

1751 Suspicions of two bridgehead invasions of Xylella fastidiosa subsp. multiplex in France

Dupas, E.; Durand, K.; Rieux, A.; Briand, M.; Pruvost, O.; Cunty, A.; Denance, N.; Donnadieu, C.; Legendre, B.; Lopez-Roques, C.; Cesbron, S.; Ravigne, V.; Jacques, M.-A.

10.1101/2022.02.11.480026 — microbiology — Posted on 2023-01-20

1752 Analysis of Biodeterioration on Ancestral Halls with Different Visitor Flow Rates Using Amplicon Sequencing and Conventional Culturing Methods

Liu, M.; Su, X.; Wen, Q.; Yang, T.; Lin, M.; Abudureyimu, P.; Lon, J. R.; Luo, J.

10.1101/2023.01.19.524717 — microbiology — Posted on 2023-01-20

1753 Locating causal hubs of memory consolidation in spontaneous brain network

Li, Z.; Athwal, D.; Lee, H.-L.; Sah, P.; Opazo, P.; Chuang, K.-H.

10.1101/2022.05.08.490699 — animal behavior and cognition — Posted on 2023-01-19

1754 Plasmid carriage and the unorthodox use of Fisher's theorem in evolutionary biology

Reding, C.

10.1101/810259 — evolutionary biology — Posted on 2023-01-19

1755 Human-caused wolf mortality persists for years after discontinuation of hunting

Oliynyk, R. T.

10.1101/2022.12.20.521126 — ecology — Posted on 2023-01-19

1756 Towards the biogeography of butyrate-producing bacteria

Brame, J. E.; Liddicoat, C.; Abbott, C. A.; Edwards, R. A.; Robinson, J. M.; Gauthier, N. E.; Breed, M. F.

10.1101/2022.10.07.510278 — ecology — Posted on 2023-01-20

1757 Diffusing fraction of niche BMP ligand safeguards stem-cell differentiation

Ridwan, S. M.; Twillie, A.; Matsuda, S.; Antel, M.; Bener, M. B.; Cowan, A. E.; Inaba, M.

10.1101/2022.09.13.507868 — developmental biology — Posted on 2023-01-20

1758 Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window

Vagnozzi, A. N.; Moore, M. T.; Lopez de Boer, R.; Agarwal, A.; Zampieri, N.; Landmesser, L. T.; Philippidou, P.

10.1101/2023.01.18.524559 — neuroscience — Posted on 2023-01-19

1759 Analysis of convolutional neural networks reveals the computational properties essential for subcortical processing of facial expression

Lim, C.; Inagaki, M.; Shinozaki, T.; Fujita, I.

10.1101/2023.01.18.524656 — neuroscience — Posted on 2023-01-19

1760 Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons

Kisner, A.; Polter, A. M.

10.1101/2023.01.19.524776 — neuroscience — Posted on 2023-01-19

1761 Gesture profiles distinguish primary progressive aphasia variants

Dresang, H. C.; Williamson, R.; Kim, H.; Hillis, A. E.; Buxbaum, L. J.

10.1101/2023.01.19.524719 — neuroscience — Posted on 2023-01-19

1762 Functional characterization of the language network of polyglots and hyperpolyglots with precision fMRI

Malik-Moraleda, S.; Jouravlev, O.; Mineroff, Z.; Cucu, T.; Taliaferro, M.; Mahowald, K.; Blank, I. A.; Fedorenko, E.

10.1101/2023.01.19.524657 — neuroscience — Posted on 2023-01-19

1763 Hemodynamic transient and functional connectivity follow structural connectivity and cell type over the brain hierarch

Chuang, K.-H.; Li, Z.; Huang, H.; Khorasani Gerdekoohi, S.; Athwal, D.

10.1101/2022.05.06.490832 — neuroscience — Posted on 2023-01-19

1764 Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex

Bachschmid-Romano, L.; Hatsopoulos, N.; Brunel, N.

10.1101/2022.02.19.481140 — neuroscience — Posted on 2023-01-20

1765 Learning to predict future locations with internally generated theta sequences

Parra-Barrero, E.; Cheng, S.

10.1101/2023.01.19.524705 — neuroscience — Posted on 2023-01-20

1766 Is shape in the eye of the beholder? The reproducibility of geometric morphometric analyses on live fish

Moccetti, P.; Rodger, J. R.; Bolland, J. D.; Kaiser-Wilks, P.; Smith, R.; Nunn, A. D.; Adams, C. E.; Bright, J. A.; Honkanen, H. M.; Lothian, A. J.; Newton, M.; Joyce, D. A.

10.1101/2022.10.11.509915 — zoology — Posted on 2023-01-19

1767 A 3-dimensional molecular cartography of human cerebral organoids revealed by double-barcoded spatial transcriptomics

Lozachmeur, G.; Bramoulle, A.; Aubert, A.; Studer, F.; Moehlin, J.; Madrange, L.; Yates, F.; Deslys, J.-P.; Mendoza-Parra, M. A.

10.1101/2023.01.18.524520 — systems biology — Posted on 2023-01-19

1768 Amino acid sequence assignment from single molecule peptide sequencing data using a two-stage classifier

Smith, M. B.; Simpson, Z. B.; Marcotte, E. M.

10.1101/2022.09.23.509260 — bioinformatics — Posted on 2023-01-19

1769 Evidence for a competitive relationship between executive functions and statistical learning

Pedraza, F.; Farkas, B. C.; Vekony, T.; Haesebaert, F.; Janacsek, K.; Anders, R.; Tillmann, B.; Plancher, G.; Nemeth, D.

10.1101/2023.01.19.524710 — animal behavior and cognition — Posted on 2023-01-19

1770 The effect of Drosophila attP40 background on the glomerular organization of Or47b olfactory receptor neurons

Duan, Q.; Estrella, R.; Carson, A.; Chen, Y.; VOLKAN, P. C.

10.1101/2022.06.16.496338 — genetics — Posted on 2023-01-19

1771 Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

Simon, N.; Safyan, A.; Pyrowolakis, G.; Matsuda, S.

10.1101/2023.01.15.524087 — developmental biology — Posted on 2023-01-19

1772 The Import of Skin Tissue Dynamics in Tactile Sensing

Rongala, U. B.; Seyfarth, A.; Hayward, V.; Jorntell, H.

10.1101/2021.09.06.459180 — neuroscience — Posted on 2023-01-19

1773 Estimating the energy requirements for long term memory formation

Girard, M.; Jiang, J.; van Rossum, M. C.

10.1101/2023.01.16.524203 — neuroscience — Posted on 2023-01-19

1774 Gender impacts the relationship between mood disorder symptoms and effortful avoidance performance

Forys, B. J.; Tomm, R. J.; Stamboliyska, D.; Terpstra, A. R.; Clark, L.; Chakrabarty, T.; Floresco, S. B.; Todd, R. M.

10.1101/2022.06.21.497075 — neuroscience — Posted on 2023-01-19

1775 Temporal progression along discrete coding states during decision-making in the mouse gustatory cortex

Lang, L.; La Camera, G.; Fontanini, A.

10.1101/2022.07.20.500889 — neuroscience — Posted on 2023-01-19

1776 A profile likelihood-based workflow for identifiability analysis, estimation, and prediction with mechanistic mathematical models

Simpson, M. J.; Maclaren, O. J.

10.1101/2022.12.14.520367 — systems biology — Posted on 2023-01-19

1777 Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing

Garana, B. B.; Joly, J. H.; Delfarah, A.; Hong, H.; Graham, N. A.

10.1101/2022.03.15.484520 — bioinformatics — Posted on 2023-01-19

1778 Correspondence analysis for dimension reduction, batch integration, and visualization of single-cell RNA-seq data

Hsu, L. L.; Culhane, A. C.

10.1101/2021.11.24.469874 — bioinformatics — Posted on 2023-01-19

1779 Distinct roles for canonical and variant histone H3 lysine 36 in Polycomb silencing

Salzler, H. R.; Vandadi, V.; McMichael, B. D.; Brown, J. C.; Boerma, S. A.; Leatham-Jensen, M. P.; Adams, K. M.; Meers, M. P.; Simon, J. M.; Duronio, R. J.; McKay, D. J.; Matera, A. G.

10.1101/2022.10.11.511749 — genomics — Posted on 2023-01-19

1780 Weevil carbohydrate intake triggers endosymbiont proliferation: a trade-off between host benefit and endosymbiont burden

Dell'Aglio, E.; Lacotte, V.; Peignier, S.; Rahioui, I.; Benzaoui, F.; Vallier, A.; Silva, P. d.; Desouhant, E.; Heddi, A.; Rebollo, R.

10.1101/2022.07.06.498660 — evolutionary biology — Posted on 2023-01-19

1781 Mechanical Causation of Biological Structure: Productive Pulls Produce Persistent Filaments in a Human Fibroblast Model of Matrix Development

Silverman, A. A.; Olszewski, J. D.; Siadat, S. M.; Ruberti, J. W.

10.1101/2021.09.10.459665 — developmental biology — Posted on 2023-01-19

1782 NuRD independent Mi-2 activity represses ectopic gene expression during neuronal maturation.

Aughey, G. N.; Forsberg, E.; Grimes, K.; Zhang, S.; Southall, T. D.

10.1101/2022.04.19.488642 — developmental biology — Posted on 2023-01-19

1783 Cystine/glutamate antiporter system Xc- deficiency impairs insulin secretion.

de Baat, A.; Meier, D. T.; Rachid, L.; Fontana, A.; Boeni, M.; Donath, M. Y.

10.1101/2023.01.19.524735 — molecular biology — Posted on 2023-01-19

1784 PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity

Sundarraj, J.; Patel, M.; Aziz, H.; Brooke, G.; Tummala, H.; Madapura, P.

10.1101/2022.12.02.518862 — molecular biology — Posted on 2023-01-19

1785 Protein Complexes in cells by AI-assisted structural proteomics

O'Reilly, F. J.; Graziadei, A.; Forbrig, C.; Bremenkamp, R.; Charles, K.; Lenz, S.; Elfmann, C.; Fischer, L.; Stuelke, J.; Rappsilber, J.

10.1101/2022.07.26.501605 — molecular biology — Posted on 2023-01-19

1786 Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates the axon guidance genes robo2 and slit in Drosophila

Singh, B. N.; Tran, H.; Kramer, J.; Kirishenko, E.; Changela, N.; Wang, F.; Feng, Y.; Kumar, D.; Tu, M.; Lan, J.; Bizet, M.; Fuks, F.; Steward, R.

10.1101/2023.01.03.522592 — neuroscience — Posted on 2023-01-19

1787 The striatum drives the ergogenic effects of caffeine

Alves, A. C. d. B.; Speck, A. E.; Farias, H. R.; dos Santos, N. S.; Pannata, G. d. S.; Tavares, A. P.; Martins, L. M.; de Oliveira, J.; Tome, A. R.; Cunha, R.; Aguiar, A. S.

10.1101/2022.10.06.511163 — neuroscience — Posted on 2023-01-19

1788 Layer-Specific Vulnerability is a Mechanism of Topographic Map Aging

Northall, A.; Doehler, J.; Weber, M.; Vielhaber, S.; Schreiber, S.; Kuehn, E.

10.1101/2022.05.29.493865 — neuroscience — Posted on 2023-01-19

1789 Predictive Motor Control Based on a Generative Adversarial Network

Lenninger, M.; Choi, W.-H.; Choi, H.

10.1101/2023.01.17.524156 — neuroscience — Posted on 2023-01-19

1790 A workflow for incorporating cross-sectional data into the calibration of dynamic models

Fischer-Holzhausen, S.; Roeblitz, S.

10.1101/2023.01.17.523407 — systems biology — Posted on 2023-01-19

1791 A multi-kingdom genetic barcoding system for precise target clone isolation

10.1101/2023.01.18.524633 — synthetic biology — Posted on 2023-01-19

1792 Examination of 2D frontal and sagittal markerless motion capture: Implications for 2D and 3D markerless applications

Wade, L.; Needham, L.; Evans, M.; McGuigan, M. P.; Colyer, S.; Cosker, D.; Bilzon, J.

10.1101/2023.01.17.523930 — bioengineering — Posted on 2023-01-19

1793 Metacommunity Structure Preserves Genome Diversity in the Presence of Gene-specific Selective Sweeps.

Pompei, S.; Bella, E.; Weitz, J.; Grilli, J.; Cosentino Lagomarsino, M.

10.1101/2023.01.17.524383 — evolutionary biology — Posted on 2023-01-19

1794 Migratory patterns of two major influenza virus host species on tropical islands

Lebarbenchon, C.; Boucher, S.; Feare, C.; Dietrich, M.; Larose, C.; Humeau, L.; Le Corre, M.; Jaeger, A.

10.1101/2023.01.18.524666 — ecology — Posted on 2023-01-19

1795 Microbial community-based bacterial protein from soybean-processing wastewater as a value-added alternative fish feed ingredient for Asian sea bass (Lates calcarifer)

Santillan, E.; Yasumaru, F.; Vethathirri, R. S.; Thi, S. S.; Hoon, H. Y.; Chan Pek Sian, D.; Wuertz, S.

10.1101/2023.01.18.524524 — microbiology — Posted on 2023-01-19

1796 Analysis of Biodeterioration on Ancestral Halls with Different Visitor Flow Rates Using Amplicon Sequencing and Conventional Culturing Methods

Liu, M.; Su, X.; Wen, Q.; Yang, T.; Lin, M.; Abudureyimu, P.; Lon, J. R.; Luo, J.

10.1101/2023.01.19.524717 — microbiology — Posted on 2023-01-19

1797 A single dietary factor, daily consumption of a fermented beverage, can modulate the gut microbiome within the same ethnic community

Das, S.; Ozkurt, E.; Joishy, T. K.; Deb, D.; Mukherjee, A. K.; Hildebrand, F.; Khan, M. R.

10.1101/2023.01.18.524612 — microbiology — Posted on 2023-01-19

1798 Validation and characterization of a viral antisense transcript with Northern blot analysis and qRT-PCR

Kara, M.

10.1101/2023.01.18.524592 — microbiology — Posted on 2023-01-19

1799 A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish

Robertson, T. F.; Hou, Y.; Shen, S.; Rindy, J.; Sauer, J.-D.; Dinh, H. Q.; Huttenlocher, A.

10.1101/2023.01.17.524414 — immunology — Posted on 2023-01-19

1800 Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation

Vanrobaeys, Y.; Peterson, Z.; Walsh, E.; Chatterjee, S.; Lin, L.-C.; Lyons, L.; Nickl-Jockschat, T.; Abel, T.

10.1101/2023.01.18.524406 — neuroscience — Posted on 2023-01-19

1801 Conic analysis of nonlinear metabolic networks

Taylor, J.; Rapaport, A.; Dochain, D.

10.1101/2023.01.17.524421 — systems biology — Posted on 2023-01-19

1802 Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture

Knyphausen, P.; Rangel Pereira, M.; Brear, P.; Hyvonen, M.; Jermutus, L.; Hollfelder, F.

10.1101/2023.01.19.524706 — synthetic biology — Posted on 2023-01-19

1803 Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma

Xu, Y.; Spear, S.; Ma, Y.; Lorentzen, M. P.; Gruet, M.; McKinney, F.; Xu, Y.; Wickremesinghe, C.; Shepherd, M.; McNeish, I.; Keun, H. C.; Nijhuis, A.

10.1101/2023.01.18.524417 — cancer biology — Posted on 2023-01-19

1804 p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

Grit, J. L.; McGee, L. E.; Tovar, E. A.; Essenburg, C. J.; Wolfrum, E.; Beddows, I.; Williams, K.; Sheridan, R.; Schipper, J.; Adams, M.; Arumugam, M.; Vander Woude, T.; Gurunathan, S.; Field, J. M.; Wulfkuhle, J.; Petricoin, E. F.; Graveel, C. R.; Steensma, M.

10.1101/2023.01.18.523629 — cancer biology — Posted on 2023-01-19

1805 AlphaFold Prediction of Structural Ensembles of Disordered Proteins

Brotzakis, Z. F.; Zhang, S.; Vendruscolo, M.

10.1101/2023.01.19.524720 — biophysics — Posted on 2023-01-19

1806 Yeast eukaryotic initiation factor 4B remodels the mRNA entry site on the small ribosomal subunit

Datey, A.; Khaja, F. T.; Rahil, H.; Hussain, T.

10.1101/2023.01.18.524494 — biophysics — Posted on 2023-01-19

1807 FedDP: Secure Federated Learning for Disease Prediction with Imbalanced Genetic Data

Li, B.; Gao, H.; Shi, X.

10.1101/2023.01.17.524409 — bioinformatics — Posted on 2023-01-19

1808 SUMO interacting motif (SIM) of S100A1 is critical for S100A1 post-translational protein stability

Jebessa, Z. H.; Glaser, M.; Zhao, J.; Schneider, A.; Seenivasan, R.; Busch, M.; Ritterhoff, J.; Wade, R. C.; Most, P.

10.1101/2023.01.18.524665 — biochemistry — Posted on 2023-01-19

1809 Combined CRISPR and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression

Tian, Y.; Dong, D.; Wu, L.; Park, J.; Wei, G.-H.; Wang, L.; PRACTICAL/ELLIPSE consortium,

10.1101/2023.01.18.524405 — genetics — Posted on 2023-01-19

1810 Transposon mutagenesis libraries reveal novel molecular requirements during CRISPR RNA-guided DNA integration

Walker, M. W. G.; Klompe, S. E.; Zhang, D. J.; Sternberg, S. H.

10.1101/2023.01.19.524723 — genetics — Posted on 2023-01-19

1811 Lemur gut microeukaryotic community variation is not associated with host phylogeny, diet, or habitat

Donohue, M. E.; Hert, Z. L.; Karrick, C. E.; Rowe, A. K.; Wright, P. C.; Randriamanandaza, L. J.; Zakamanana, F.; Nomenjanahary, S.; Everson, K. M.; Weisrock, D. W.

10.1101/2023.01.17.524408 — evolutionary biology — Posted on 2023-01-19

1812 Viral capsid, antibody, and receptor interactions: experimental analysis of the antibody escape evolution of canine parvovirus

Lopez-Astacio, R.; Adu, O. F.; Goetschius, D. J.; Lee, H.; Weichert, W.; Wasik, B. R.; Frueh, S. P.; Alford, B. K.; Voorhees, I. E. H.; Flint, J. F.; Saddoris, S.; Goodman, L. B.; Holmes, E. C.; Hafenstein, S.; Parrish, C. R.

10.1101/2023.01.18.524668 — evolutionary biology — Posted on 2023-01-19

1813 Widespread distribution and evolution of poxviral entry-fusion complex proteins in giant viruses

Kao, S.; Kao, C.-F.; Chang, W.; Ku, C.

10.1101/2023.01.19.524718 — evolutionary biology — Posted on 2023-01-19

1814 Adaptations to water stress and pastoralism in the Turkana of northwest Kenya

Lea, A. J.; Caldas, I. V.; Garske, K. M.; Echwa, J.; Gurven, M.; Handley, C.; Kahumbu, J.; Kamau, J.; Kinyua, P.; Lotukoi, F.; Lopurudoi, A.; Lowasa, S.; Mallarino, R.; Martins, D.; Messer, P. W.; Miano, C.; Muhoya, B.; Peng, J.; Phung, T.; Rabinowitz, J. D.; Roichman, A.; Siford, R.; Stone, A.; Taravella-Oill, A. M.; Mathew, S.; Wilson, M. A.; Ayroles, J. F.

10.1101/2023.01.17.524066 — evolutionary biology — Posted on 2023-01-19

1815 Data stochasticity and model parametrisation impact the performance of species distribution models: insights from a simulation study

Lambert, C.; Virgili, A.

10.1101/2023.01.17.524386 — ecology — Posted on 2023-01-19

1816 Collateral RNA cleavage by CRISPR-Cas13 allows selective cell elimination

Bot, J. F.; Zhao, Z.; Kammeron, D.; Shang, P.; Geijsen, N.

10.1101/2023.01.19.524716 — molecular biology — Posted on 2023-01-19

1817 Gravitational and mechanical forces drive mitochondrial translation through the cell adhesion-FAK axis

Wakigawa, T.; Kimura, Y.; Mito, M.; Tsubaki, T.; Saito, H.; Khan, A. H.; Yamamori, T.; Yamazaki, T.; Higashibata, A.; Tsuboi, T.; Saito, T.; Higashitani, A.; Shichino, Y.; Iwasaki, S.

10.1101/2023.01.18.524628 — molecular biology — Posted on 2023-01-19

1818 HIV-PULSE: A long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Lambrechts, L.; Bonine, N.; Verstraeten, R.; Pardons, M.; Noppe, Y.; Rutsaert, S.; Van Nieuwerburgh, F.; Van Criekinge, W.; Cole, B.; Vandekerckhove, L.

10.1101/2023.01.18.524396 — molecular biology — Posted on 2023-01-19

1819 IFI207, a young and fast-evolving antiviral factor, stabilizes STING

Moran, E. A.; Salas-Briceno, K.; Aguilera, A.; Keane, T.; Adams, D.; Lilue, J.; Ross, S. R.

10.1101/2023.01.19.524411 — microbiology — Posted on 2023-01-19

1820 Long-read direct RNA sequencing of the mitochondrial transcriptome of Saccharomyces cerevisiae reveals condition-dependent intron turnover

Koster, C. C.; Kleefeldt, A.; van den Broek, M.; Luttik, M.; Daran, J.-M. G.; Daran-Lapujade, P.

10.1101/2023.01.19.524680 — microbiology — Posted on 2023-01-19

1821 Plant selection and ecological microhabitat drive domestications of shrub-associated microbiomes in a revegetated shrub ecosystem

Lai, Z.; Sun, Y.; Yu, Y.; Liu, Z.; Bai, Y.; Qiao, Y.; Miao, L.; She, W.; Qin, S.; Feng, W.

10.1101/2023.01.19.524707 — microbiology — Posted on 2023-01-19

1822 Molecular Imaging with Fibroblast Activation Protein Tracers depicts Inflammatory Joint Damage and its Transition to Resolution of Inflammation

Rauber, S.; Mohammadian, H.; Schmidkonz, C.; Atzinger, A.; Soare, A.; Maschauer, S.; Treutlein, C.; Angeli, M.; Raimondo, M. G.; Xu, C.; Yang, K.-T.; Lu, L.; Labinsky, H.; Kampylafka, E.; Knitza, J.; Maric, H.; Distler, J. H. W.; Baeuerle, T.; Kuwert, T.; Prante, O.; Canete, J.; Schett, G.; Ramming, A.

10.1101/2023.01.17.524425 — immunology — Posted on 2023-01-19

1823 Molecular and functional properties of human Plasmodium falciparum CSP C-terminus antibodies

Oludada, O. E.; Costa, G.; Burn Aschner, C.; Obraztsova, A.; Prieto, K.; Canetta, C.; Hoffmann, S. L.; Kremsner, P.; Mordmueller, B.; Murugan, R.; Julien, J.-P.; Levashina, E. A.; Wardemann, H.

10.1101/2023.01.19.524692 — immunology — Posted on 2023-01-19

1824 The inflammatory and tumor suppressor SAMD9L acts through a Schlafen-like box to restrict HIV and inhibit cell translation in SAAD/ATXPC

Legrand, A.; Dahoui, C.; De La Myre Mory, C.; Loyer, C.; Noy, K.; Guiguettaz, L.; Pillon, M.; Wcislo, M.; Gueguen, L.; Cimarelli, A.; Mateo, M.; Fiorini, F.; Ricci, E.; Etienne, L.

10.1101/2023.01.19.524725 — immunology — Posted on 2023-01-19

1825 Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells

Medrano, M.; Allaoui, W.; Van Bulck, M.; Thys, S.; Makrini-Maleville, L.; Seuntjens, E.; de Vos, W. H.; Valjent, E.; Gaszner, B.; Van Eeckhaut, A.; Smolders, I.; De Bundel, D.

10.1101/2023.01.19.524191 — neuroscience — Posted on 2023-01-19

1826 Size tuning of neural response variability in laminar circuits of macaque primary visual cortex

Nurminen, L.; Bijanzadeh, M.; Angelucci, A.

10.1101/2023.01.17.524397 — neuroscience — Posted on 2023-01-19

1827 Elevation of NAD+ by nicotinamide riboside spares spinal cord tissue from injury and promotes locomotor recovery

Metcalfe, M.; David, B. T.; Langley, B. C.; Hill, C. E.

10.1101/2023.01.17.524307 — neuroscience — Posted on 2023-01-19

1828 GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes

Sivadasan Bindu, D.; Tan, C. X.; Savage, J. T.; Eroglu, C.

10.1101/2023.01.17.524433 — neuroscience — Posted on 2023-01-19

1829 Bromodomain-containing Protein 4 Regulates Innate Inflammation in Airway Epithelial Cells via Modulation of Alternative Splicing

Mann, M. W.; Fu, Y.; Xu, X.; Roberts, D. S.; Li, Y.; Zhou, J.; Ge, Y.; Brasier, A. R.

10.1101/2023.01.17.524257 — systems biology — Posted on 2023-01-19

1830 TReSR: A PCR-compatible DNA sequence design method for engineering proteins containing tandem repeats

Davey, J. A.; Goto, N. K.

10.1101/2023.01.19.524698 — synthetic biology — Posted on 2023-01-19

1831 MCB-613 exploits a collateral sensitivity in drug-resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1

Bassil, C. F.; Anderson, G. R.; Mayro, B.; Askin, K. N.; Winter, P. S.; Gruber, S.; Hall, T. M.; Hoj, J. P.; Cerda-Smith, C.; Hutchinson, H. M.; Killarney, S. T.; Singleton, K. R.; Qin, L.; Jubien-Girard, K.; Favreau, C.; Martin, A. R.; Robert, G.; Benhida, R.; Auberger, P.; Pendergast, A. M.; Lonard, D. M.; Puissant, A.; Wood, K. C.

10.1101/2023.01.17.524094 — cancer biology — Posted on 2023-01-19

1832 MOXD1 is a gate-keeper of organ homeostasis and functions as a tumor-suppressor in neuroblastoma

Fredlund, E.; Andersson, S.; Hilgert, E.; Alvarez-Hernan, G.; Monferrer, E.; Karakaya, S.; Gregor, T.; Loontiens, S.; Bek, J. W.; Lecomte, E.; Magnusson, E.; Miltenyte, E.; Cabirol, M.; Kyknas, M.; Engstrom, N.; Arsenian Henriksson, M.; Hammarlund, E.; Noguera, R.; Speleman, F.; van Nes, J.; Mohlin, S.

10.1101/2023.01.17.524367 — cancer biology — Posted on 2023-01-19

1833 Lateral membrane organization as target of an antimicrobial peptidomimetic compound

Melcrova, A.; Maity, S.; Melcr, J.; de Kok, N. A. W.; Gabler, M.; van der Eyden, J.; Stensen, W.; Svendsen, J. S. M.; Driessen, A. J. M.; Marrink, S.-J.; Roos, W. H.

10.1101/2023.01.17.524350 — biophysics — Posted on 2023-01-19

1834 Predicting Protein-encoding Gene Content in Escherichia coli Genomes

Nguyen, M.; Elmore, Z.; Ihle, C.; Moen, F. S.; Slater, A. D.; Turner, B. N.; Parrello, B.; Best, A. A.; Davis, J. J.

10.1101/2023.01.17.524402 — bioinformatics — Posted on 2023-01-19

1835 ProteoM enables deep and precise identification of peptides in data-dependent acquisition proteomics

Zhang, Q.

10.1101/2023.01.17.524387 — bioinformatics — Posted on 2023-01-19

1836 Bayesian Differential Analysis of Cell Type Proportions

Karagiannis, T.; Monti, S.; Sebastiani, P.

10.1101/2023.01.17.524410 — bioinformatics — Posted on 2023-01-19

1837 GraphGPSM: a global scoring model for protein structure using graph neural networks

He, G.; Liu, J.; Liu, D.; Zhang, G.

10.1101/2023.01.17.524382 — bioinformatics — Posted on 2023-01-19

1838 curatedPCaData: Integration of clinical, genomic, and signature features in a curated and harmonized prostate cancer data resource

Laajala, T. D.; Sreekanth, V.; Soupir, A.; Creed, J. H.; Calboli, F.; Singaravelu, K.; Orman, M.; Colin-Leitzinger, C.; Gerke, T.; Fidley, B.; Tyekucheva, S.; Costello, J. C.

10.1101/2023.01.17.524403 — bioinformatics — Posted on 2023-01-19

1839 Adaptive optical two-photon fluorescence microscopy probes cellular organization of ocular lenses in vivo

Paidi, S. K.; Zhang, Q.; Yang, Y.; Xia, C.-h.; Ji, N.; Gong, X.

10.1101/2023.01.17.524320 — bioengineering — Posted on 2023-01-19

1840 Accounting for unobserved spatial variation in step selection analyses of animal movement via spatial random effects

Arce Guillen, R.; Lindgren, F.; Muff, S.; Glass, T. W.; Breed, G. A.; Schlaegel, U. E.

10.1101/2023.01.17.524368 — animal behavior and cognition — Posted on 2023-01-19

1841 Surveillance of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Tan, C.; Trew, J.; Peacock, T. P.; Mok, K.; Hart, C.; Lau, K.; Ni, D.; Orme, D.; Ransome, E.; Pearse, W.; Coleman, C.; Bailey, D.; Thakur, N.; Quantrill, J.; Sukhova, K.; Richard, D.; Woodward, G.; Bell, T.; Worledge, L.; Nunez-Mino, J.; Tarlinton, R. E.; Apaa, T.; Matthews, F.; Barclay, W. S.; van Dorp, L.; Balloux, F.; Savolainen, V.

10.1101/2023.01.17.524183 — genomics — Posted on 2023-01-19

1842 Species delimitation of eight ascidian (Tunicata) species from the North Eastern Mediterranean

Karahan, A.; Temiz, B.; Ozturk, E.; Douek, J.; Rinkevich, B.

10.1101/2023.01.17.523747 — genetics — Posted on 2023-01-19

1843 Substance use is related to differential activation and connectivity for social relative to monetary rewards

Wyngaarden, J. B.; Johnston, C. R.; Sazhin, D.; Dennison, J. B.; Zaff, O.; Fareri, D.; McCloskey, M.; Alloy, L. B.; Smith, D. V.; Jarcho, J. M.

10.1101/2023.01.17.524305 — neuroscience — Posted on 2023-01-19

1844 Retinal affectation in Huntington's disease mouse models concurs with a local innate immune response

Arroba, A. I.; Gallardo-Orihuela, A.; Cano-Cano, F.; Martin-Loro, F.; Gonzalez-Montelongo, M. d. C.; Hervas-Corpion, I.; de la Villa, P.; Ramon-Marco, L.; Gomez-Jaramillo, L.; Valor, L. M.

10.1101/2023.01.17.523578 — neuroscience — Posted on 2023-01-19

1845 Motor cortex retains and reorients neural dynamics during motor imagery

Dekleva, B. M.; Chowdhury, R. H.; Batista, A. P.; Chase, S. M.; Yu, B. M.; Boninger, M. L.; Collinger, J. L.

10.1101/2023.01.17.524394 — neuroscience — Posted on 2023-01-19

1846 Oligodendrocyte dynamics dictate individual performance outcomes of working memory training in mice

Shimizu, T.; Nayar, S. G.; Swire, M.; Jiang, Y.; Grist, M.; Bannerman, D. M.; Johansen-Berg, H.; Ogasawara, K.; Tohyama, K.; Richardson, W. D.

10.1101/2023.01.17.524381 — neuroscience — Posted on 2023-01-19

1847 Tiered Sympathetic Control of Cardiac Function Revealed by Viral Tracing and Single Cell Transcriptome Profiling

Sharma, S.; Littman, R.; Tompkins, J.; Arneson, D.; Contreras, J.; Dajani, A.-H.; Ang, K.; Tsanhani, A.; Sun, X.; Jay, P. Y.; Herzog, H.; Yang, X.; Ajijola, O. A.

10.1101/2023.01.18.524575 — neuroscience — Posted on 2023-01-19

1848 Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation

Vanrobeys, Y.; Mukherjee, U.; Langmack, L.; Bahl, E.; Lin, L.-C.; Michaelson, J. J.; Abel, T.; Chatterjee, S.

10.1101/2023.01.18.524576 — neuroscience — Posted on 2023-01-19

1849 Molecular Logic of Synaptic Diversity Between Drosophila Tonic and Phasic Motoneurons

Jetti, S. J.; Crane, A. B.; Akbergenova, Y.; Aponte-Santiago, N. A.; Cunningham, K. L.; Whittaker, C. W.; Littleton, J. T.

10.1101/2023.01.17.524447 — neuroscience — Posted on 2023-01-19

1850 Conserved cis-acting motifs and localization of transcripts and proteins of MFT2 in barley and rice

Utsugi, S.; Kawahigashi, H.; Tagiri, A.; Kikuchi, R.; Mishina, K.; Morishige, H.; Nakamura, S.

10.1101/2023.01.17.524348 — plant biology — Posted on 2023-01-19

1851 Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs

Samarin, J.; Fabrowski, P.; Kurilov, R.; Nuskova, H.; Hummel-Eisenbeiss, J.; Pink, H.; Li, N.; Weru, V.; Alborzinia, H.; Yildiz, U.; Grob, L.; Taubert, M.; Czech, M.; Morgen, M.; Brandstaedter, C.; Goncalves, A.; Uhrig, U.; Seiler, J.; Lyu, Y.; Diederichs, S.; Klingmueller, U.; Muckenthaler, M.; Kopp-Schneider, A.; Teleman, A.; Miller, A. K.; Gunkel, N.

10.1101/2023.01.17.524372 — cancer biology — Posted on 2023-01-19

1852 Deprivation of arginine and lysine interferes with growth of patient-derived tumor xenografts

Wolkersdorfer, A.; Bergmann, B.; Adelmann, J.; Ebbinghaus, M.; Guenther, E.; Gutmann, M.; Hahn, L.; Hurwitz, R.; Luehmann, T.; Schueler, J.; Schmidt, L.; Teifel, M.; Meinel, L.; Rudel, T.

10.1101/2023.01.17.524398 — cancer biology — Posted on 2023-01-19

1853 SARS-CoV-2 Omicron XBB.1.5 may be a cautionary variant by in silico study

Sugano, A.; Kataguchi, H.; Ohta, M.; Someya, Y.; Kimura, S.; Maniwa, Y.; Tabata, T.; Takaoka, Y.

10.1101/2023.01.18.524660 — bioinformatics — Posted on 2023-01-19

1854 Effect of oncolytic virotherapy on immune microenvironment in immune subtypes identified in gastric cancer and hepatocellular carcinoma

Wang, Z.; Peng, S.; Chen, X.; Xie, Z.; Li, S.

10.1101/2023.01.17.524374 — bioinformatics — Posted on 2023-01-19

1855 Ensemble of deep learning language models to support the creation of living systematic reviews for the COVID-19 literature: a retrospective study

Knafou, J.; Haas, Q.; Borissov, N.; Counotte, M. J.; Low, N.; Imeri, H.; Ipekci, A. M.; Buitrago-Garcia, D.; Heron, L.; Amini, P.; Teodoro, D.

10.1101/2023.01.18.524571 — bioinformatics — Posted on 2023-01-19

1856 Immunogenicity and safety in pigs of PHH-1V, a SARS-CoV-2 RBD fusion heterodimer vaccine candidate

Moros, A.; Prefaneta, A.; Barreiro, A.; Perozo, E.; Fernandez, A.; Canete, M.; Gonzalez, L.; Garriga, C.; Pradenas, E.; Marfil, S.; Blanco, J.; Cebollada-Rica, P.; Sistere-Oro, M.; Meyerhans, A.; Prat Cabanas, T.; March, R.; Ferrer, L.

10.1101/2023.01.19.524684 — immunology — Posted on 2023-01-19

1857 A review of online learning strategies for biological NMR techniques a survey of educators

Phelan, M. M.

10.1101/2023.01.13.523927 — scientific communication and education — Posted on 2023-01-19

1858 Efficiency enhancement of microparticles seeding density on the inner surface of polymer hollow microfibers using microfluidics

Aykar, S. S.; Hashemi, N. N.

10.1101/2023.01.16.524327 — bioengineering — Posted on 2023-01-19

1859 A dual MTOR/NAD+ acting gerotherapy

Li, J.; Kumar, S.; Miachin, K.; Bean, N. L.; Halawi, O.; Lee, S.; Niehoff, M.; Pierre, T. H.; Colca, J.; Kletzien, R. F.; Tanis, S. P.; Chen, Y.; Griffett, K.; Niehoff, M.; Miller, T. M.; Hor, J.-H.; Ng, S.-Y.; Wallace, K.; Rindtorff, N.; Farr, S. A.; McCommis, K. S.; Finck, B. N.; Peterson, T. R.

10.1101/2023.01.16.523975 — genomics — Posted on 2023-01-19

1860 Reintroducing genetic diversity in populations from cryopreserved material: The case of Abondance, a French local dairy cattle breed

Jacques, A.; Leroy, G.; Rognon, X.; Verrier, E.; Tixier-Boichard, M.; RESTOUX, G.

10.1101/2023.01.17.524356 — genetics — Posted on 2023-01-19

1861 A field theoretic approach to non-equilibrium population genetics in the strong selection regime

Balick, D. J.

10.1101/2023.01.16.524324 — genetics — Posted on 2023-01-19

1862 FROM FOREST TO SAVANNA AND BACK TO FOREST: EVOLUTIONARY HISTORY OF THE GENUS Dimorphandra (LEGUMINOSAE)

Rocha, V. D. d.; Dal'Sasso, T. C. S.; Williams, C. C. V.; Simon, M. F.; Bueno, M. L.; Oliveira, L. O. d.

10.1101/2023.01.16.524261 — evolutionary biology — Posted on 2023-01-19

1863 The Shot CH1 domain recognises a distinct form of F-actin during Drosophila oocyte determination

Nashchekin, D.; Squires, I.; Prokop, A.; St Johnston, D.

10.1101/2023.01.18.524359 — cell biology — Posted on 2023-01-19

1864 Ciliopathy-associated missense mutations in IFT140 are hypomorphic and have edgetic effects on protein interaction networks

Leonhard, T.; Diwan, G. D.; Klose, F.; Stehle, I. F.; Junger, K.; Seda, M.; Bolz, S.; Woerz, F.; Russell, R. B.; Boldt, K.; Jenkins, D.; Ueffing, M.; Beyer, T.

10.1101/2023.01.18.523235 — cell biology — Posted on 2023-01-19

1865 Early beta-amyloid accumulation in the brain is associated with peripheral T cell alterations

Gericke, C.; Kirabali, T.; Flury, R.; Mallone, A.; Rickenbach, C.; Kulic, L.; Tosevski, V.; Hock, C.; Nitsch, R. M.; Treyer, V.; Ferretti, M. T.; Gietl, A.

10.1101/2023.01.17.524355 — immunology — Posted on 2023-01-19

1866 Dichotomy in TCR V-domain dynamics binding the opposed inclined planes of pMHC-II and pMHC-I α-helices

Murray, J.

10.1101/2023.01.16.524284 — immunology — Posted on 2023-01-19

1867 Bridging Big Data: Procedures for Combining Non-equivalent Cognitive Measures from the ENIGMA Consortium

Kennedy, E.; Vadlamani, S.; Lindsey, H. M.; Lei, P.-W.; Pugh, M. J.; Adamson, M.; Alda, M.; Alonso-Lana, S.; Ambrogi, S.; Anderson, T. J.; Arango, C.; Asarnow, R.; Avram, M.; Ayesa-Arriola, R.; Babikian, T.; Banaj, N.; Bird, L. J.; Borgwardt, S.; Brodtmann, A.; Brosch, K.; Caeyenberghs, K.; Calhoun, V. D.; Chiaravalloti, N. D.; Cifu, D. X.; Crespo-Facorro, B.; Dalrymple-Alford, J. C.; Dams-O'Connor, K.; Dannlowski, U.; Darby, D.; Davenport, N.; DeLuca, J.; Diaz-Caneja, C. M.; Disner, S. G.; Dobryakova, E.; Ehrlich, S.; Esopenko, C.; Ferrarelli, F.; Frank, L. E.; Franz, C.; Fuentes-Claramonte,

10.1101/2023.01.16.524331 — neuroscience — Posted on 2023-01-19

1868 A recurrent network model of planning explains hippocampal replay and human behavior

Jensen, K. T.; Hennequin, G.; Mattar, M. G.

10.1101/2023.01.16.523429 — neuroscience — Posted on 2023-01-19

1869 The absence of a neurogenic response to a repeated concussive-like injury in mice

Weingarten, A.; Bah, T. M.; Yeturu, S.; Samudrala, N.; Villasana, L. E.

10.1101/2023.01.16.524157 — neuroscience — Posted on 2023-01-19

1870 Apparent simplicity and emergent robustness in bacterial cell cycle control

Govers, S. K.; Campos, M.; Tyagi, B.; Laloux, G.; Jacobs-Wagner, C.

10.1101/2023.01.16.524295 — systems biology — Posted on 2023-01-19

1871 Fly-CURE, a Multi-institutional CURE using Drosophila, Increases Students' Confidence, Sense of Belonging, and Persistence in Research

Merkle, J. A.; Devergne, O.; Kelly, S. M.; Croonquist, P. A.; Evans, C. J.; Hwalek, M. A.; Straub, V. L.; Hamill, D. R.; Puthoff, D. P.; Saville, K. J.; Siders, J. L.; Villanueva Gonzalez, Z. J.; Wittke-Thompson, J. K.; Bieser, K. L.; Stamm, J.; Vrailas-Mortimer, A. D.; Kagey, J. D.

10.1101/2023.01.16.524319 — scientific communication and education — Posted on 2023-01-19

1872 HepaRG cells undergo increased levels of post-differentiation patterning in physiologic conditions when maintained as 3D cultures in paper-based scaffolds

DiProspero, T. J.; Brown, L. G.; Fachko, T. D.; Lockett, M. R.

10.1101/2023.01.16.524330 — pharmacology and toxicology — Posted on 2023-01-19

1873 Assessing assay absorption artefacts in in vitro cell responses to particles

Yen, S.; Zosky, G. R.; Song, Y.

10.1101/2023.01.16.524328 — pharmacology and toxicology — Posted on 2023-01-19

1874 Ccn2 deficiency causes smooth muscle cell de-differentiation and severe atherosclerosis in hyperlipidemic mice

Larsen, J. H.; Stubbe, J.; Beck, H. C.; Overgaard, M.; Lindegaard, C. A.; Hansen, D. R.; Goldschmeding, R.; Rodriguez-Diez, R. R.; Ruiz-Ortega, M.; Pyke, C.; Wirka, R.; Lindholt, J. S.; Rasmussen, L. M.; Steffensen, L. B.

10.1101/2023.01.16.524161 — pathology — Posted on 2023-01-19

1875 Active Gαi/o mutants accelerate breast tumor metastasis via the c-Src pathway

Lyu, C.; Bhimani, A. K.; Draus, W. T.; Weigel, R.; Chen, S.

10.1101/2023.01.16.524334 — cancer biology — Posted on 2023-01-19

1876 The 3D coarse-graining formulation of interacting elastohydrodynamic filaments and multi-body microhydrodynamics

Fuchter, P.; Bloomfield-Gadelha, H.

10.1101/2023.01.17.524366 — biophysics — Posted on 2023-01-19

1877 Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin

Wydorski, P. M.; Osipiuk, J.; Lanham, B. T.; Tesar, C.; Endres, M.; Engle, E.; Jedrzejczak, R.; Mullapudi, V.; Michalska, K.; Fidelis, K.; Fushman, D.; Joachimiak, A.; Joachimiak, L. A.

10.1101/2021.09.15.460543 — biophysics — Posted on 2023-01-19

1878 Hierarchical Bayesian modeling identifies key considerations in the development of quantitative loop-mediated isothermal amplification assays

Mayhew, M. B.; Bradley, J. R.; Borges, D.; Cavaleiro, M.

10.1101/2023.01.16.524143 — bioinformatics — Posted on 2023-01-19

1879 A hybrid approach for predicting multi-label subcellular localization of mRNA at genome scale

Choudhury, S.; Bajiya, N.; Patiyal, S.; Raghava, G. P. S.

10.1101/2023.01.17.524365 — bioinformatics — Posted on 2023-01-19

1880 Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids

Haloi, N.; Huang, S.; Nichols, A.; Fine, E. J.; Marotta, C. B.; Dougherty, D. A.; Lindahl, E.; Howard, R. J.; Mayo, S. L.; Lester, H. A.

10.1101/2023.01.16.524298 — bioengineering — Posted on 2023-01-19

1881 Non-photosynthetic bacteria produce photocurrent mediated by NADH.

Shlosberg, Y.; Limwongyut, J.; Moreland, A. S.; Bazan, G. C.

10.1101/2023.01.16.524302 — bioengineering — Posted on 2023-01-19

1882 Natural variation in Prdm9 affecting hybrid sterility phenotypes

AbuAlia, K. F. N.; Damm, E.; Ullrich, K. K.; Mukaj, A.; Parvanov, E. D.; Forejt, J.; Odenthal-Hesse, L.

10.1101/2023.01.17.524418 — genetics — Posted on 2023-01-19

1883 A single amino acid polymorphism in natural Metchnikowin alleles of Drosophila results in systemic immunity and life history tradeoffs

Perlmutter, J. I.; Chapman, J. R.; Wilkinson, M. C.; Nevarez-Saenz, I.; Unckless, R. L.

10.1101/2023.01.16.524277 — genetics — Posted on 2023-01-19

1884 Nutrient niche partitioning between tropical legumes and grasses strengthens under elevated CO2

Churchill, A. C.; Zhang, H.; Kim, G. w.; Catunda, K. L. M.; Anderson, I. C.; Isbell, F. I.; Moore, B.; Pendall, E.; Plett, J. M.; Powell, J.; Power, S. A.

10.1101/2023.01.16.524162 — ecology — Posted on 2023-01-19

1885 Does the territorial behaviour of the Amur tiger affect the accuracy of occupancy estimation?

Xie, B.; Gong, Y.; Fu, Y.; Feng, L.; Yang, H.

10.1101/2023.01.16.524338 — ecology — Posted on 2023-01-19

1886 Natural Killer cell contractility and cytotoxicity is driven by TLR3 agonist-mediated TAZ cytoplasmic sequestration

Wong, D. C. P.; Xia, Z.; Shao, N.; Yeo, J. Y.; Thivakar, T.; Yow, I.; Salazar, A. M.; Liou, Y.-C.; Low, B. C.; Ding, J. L.

10.1101/2023.01.18.524654 — cell biology — Posted on 2023-01-19

1887 PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties

Bahraoui, S.; Tejedor, G.; Mausset-Bonnefont, A.-L.; Autelitano, F.; Jorgensen, C.; Wei, M.; Djouad, F.

10.1101/2023.01.18.524662 — cell biology — Posted on 2023-01-19

1888 Continuous muscle, glial, epithelial, neuronal, and hemocyte cell lines for Drosophila research

Coleman-Gosser, N.; Raghuvanshi, S.; Stitzinger, S.; Hu, Y.; Chen, W.; Luhur, A.; Mariyappa, D.; Josifov, M.; Zelhof, A.; Mohr, S. E.; Perrimon, N.; Simcox, A.

10.1101/2023.01.18.524445 — cell biology — Posted on 2023-01-19

1889 Multiomics study of CHCHD10S59L-related disease reveals energy metabolism downregulation: OXPHOS and beta-oxidation deficiencies associated with lipids alterations

Madji Hounoum, B.; Bellon, R.; Genin, E. C.; Bannwarth, S.; Lefevre, A.; Fleuriol, L.; Debayle, D.; Gay, A.-S.; Petit-Paitel, A.; Lacas-Gervais, S.; Blasco, H.; Edmond, P.; Paquis-Flucklinger, V.; RICCI, J.-E.

10.1101/2023.01.19.524672 — cell biology — Posted on 2023-01-19

1890 Bacopa monnieri phytochemicals regulate fibroblast cell migration via modulation of focal adhesions

Zirmire, R. K.; Saha, D.; Tanimu, H.; Zaarour, R.; Bird, D.; Cherian, P.; Misra, N.; Sanyal, A.; Roy, N.; Jamora, C.

10.1101/2023.01.18.524521 — cell biology — Posted on 2023-01-19

1891 Tau tubulin kinase 1 and 2 regulate ciliogenesis and human pluripotent stem cells-derived neural rosettes

Bino, L.; Cajanek, L.

10.1101/2023.01.18.524283 — cell biology — Posted on 2023-01-19

1892 A Back-Door Insights into the modulation of Src kinase activity by the polyamine spermidine

Rossini, S.; Gagaro, M.; Scalisi, G.; Bianconi, E.; Ambrosino, S.; Panfili, E.; Volpi, C.; Orabona, C.; Macchiarulo, A.; Fallarino, F.; Mondanelli, G.

10.1101/2023.01.15.524120 — molecular biology — Posted on 2023-01-19

1893 Role of cytoneme-like structures and extracellular vesicles in Trichomonas vaginalis parasite: parasite communication

Salas, N.; Blasco Pedreros, M.; dos Santos Melo, T.; Maguire, V.; Sha, J.; Wohlschlegel, J. A.; Pereira-Neves, A.; de Miguel, N.

10.1101/2023.01.18.524507 — microbiology — Posted on 2023-01-19

1894 Label-free quantitative proteomics analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii

Xie, H.; Xu, C.; Zhao, G.; Dong, H.; Dai, L.; Xu, H.; Zhang, L.; Sun, H.; Wang, Q.; Zhang, J.; Yin, K.

10.1101/2023.01.15.524169 — microbiology — Posted on 2023-01-19

1895 3D Chromatin Dynamics during Innate and Adaptive Immune Memory Acquisition

Santosa, E. K.; Lau, C. M.; Sahin, M.; Leslie, C. S.; Sun, J. C.

10.1101/2023.01.16.524322 — immunology — Posted on 2023-01-19

1896 Preclinical Basis of the Efficacy and Pharmacodynamics of Finotonlimab, a Humanized Anti-PD-1 Monoclonal Antibody with Potent Implications for Clinical Benefit

Yang, X.; Li, J.; Guo, E.; Sun, C.; Zhang, X.; Jia, J.; Wang, R.; Ma, J.; Dai, Y.; Deng, M.; Yu, C.; Sun, L.; Li, S.; Xie, L.

10.1101/2023.01.16.524197 — immunology — Posted on 2023-01-19

1897 Sex differences in the effects of mild traumatic brain injury and progesterone treatment on anxiety-like behavior and fear conditioning in rats

Fox, L. C.; Scholl, J. L.; Palmer, G. M.; Forster, G. L.; Watt, M. J.

10.1101/2023.01.13.523944 — neuroscience — Posted on 2023-01-19

1898 Hippocampal area CA2 controls seizure dynamics, interictal EEG abnormalities and social comorbidity in mouse models of temporal lobe epilepsy

Lisgaras, C. P.; Oliva, A.; Mckenzie, S.; LaFrancois, J.; Siegelbaum, S. A.; Scharfman, H. E.

10.1101/2023.01.15.524149 — neuroscience — Posted on 2023-01-19

1899 All-optical interrogation of excitability during seizure propagation reveals high local inhibition amidst baseline excitability

Shah, P. T.; Valiante, T. A.; Packer, A.

10.1101/2023.01.16.524224 — neuroscience — Posted on 2023-01-19

1900 A large-scale Boolean model of the Rheumatoid Arthritis Fibroblast-Like Synoviocytes predicts drug synergies in the arthritic joint

Singh, V.; Naldi, A.; Soliman, S.; Niarakis, A.

10.1101/2023.01.16.524300 — systems biology — Posted on 2023-01-19

1901 Robust single membrane protein tweezers

Kim, S.; Lee, D.; Wijesinghe, W. C. B.; Min, D.

10.1101/2023.01.15.524119 — biophysics — Posted on 2023-01-19

1902 High-throughput phenotyping of infection by diverse microsporidia species reveals a wild C. elegans strain with opposing resistance and susceptibility traits

Mok, C.; Xiao, M. A.; Wan, Y. C.; Zhao, W.; Ahmed, S. M.; Luallen, R. J.; Reinke, A. W.

10.1101/2022.06.20.496912 — genomics — Posted on 2023-01-19

1903 Dbx2, an aging-related homeobox gene, inhibits the proliferation of adult neural progenitors

Giuliani, A.; Licursi, V.; Nisi, P. S.; Fiore, M.; Biagioni, S.; Negri, R.; Rugg-Gunn, P.; Cacci, E.; Lupo, G.

10.1101/2023.01.16.524218 — developmental biology — Posted on 2023-01-19

1904 HuR modulation with tanshinone mimics impairs LPS response in murine macrophages

Bonomo, I.; Assoni, G.; La Pietra, V.; Canarutto, G.; Facen, E.; Donati, G.; Zucal, C.; Genovese, S.; Micaelli, M.; Perez-Rafols, A.; Robbiati, S.; Kontoyannis, D.; De Matteo, M.; Fragai, M.; Seneci, P.; Marinelli, L.; Arosio, D.; Piazza, S.; Provenzani, A.

10.1101/2023.01.16.524289 — molecular biology — Posted on 2023-01-19

1905 Host response of Syrian hamster to SARS-CoV-2 infection, including differences with humans and between sexes

Castellan, M.; Zamperin, G.; Franzoni, G.; Foiani, G.; Zorzan, M.; Drzewniokova, P.; Mancin, M.; Brian, I.; Bortolami, A.; Pagliari, M.; Oggiano, A.; Vascellari, M.; Panzarin, V.; Crovella, S.; Monne, I.; Terregino, C.; De Benedictis, P.; Leopardi, S.

10.1101/2022.11.22.517339 — immunology — Posted on 2023-01-19

1906 Extensive and Persistent Extravascular Dermal Fibrin Deposition Characterizes Systemic Sclerosis

Browning, J. L.; Bhawan, J.; Tseng, A.; Crossland, N.; Bujor, A. M.; Akassoglou, K.; Assassi, S.; Skaug, B.; Ho, J.

10.1101/2023.01.16.523256 — pathology — Posted on 2023-01-19

1907 Novel orthotopic model of neuroblastoma in RNU homozygous rats

Sever, R. E.; Rosenblum, L. T.; Schmitt, L.; Hartwick, S.; Schwab, K.; Wu, Y.; Raphael, I.; Reyes, M.; Edwards, W. B.; Malek, M. M.; Kohanbash, G.

10.1101/2023.01.16.523967 — cancer biology — Posted on 2023-01-19

1908 nf-root: a best-practice pipeline for deep learning-based analysis of apoplastic pH in microscopy images of developmental zones in plantroot tissue

Wanner, J.; Kuhn Cuellar, L.; Rausch, L.; Berendzen, K. W.; Wanke, F.; Gabernet, G.; Harter, K.; Nahnsen, S.

10.1101/2023.01.16.524272 — bioinformatics — Posted on 2023-01-19

1909 Breast Milk Oligosaccharides Contain Immunomodulatory Glucuronic Acid and LacdiNAc

Jin, C.; Lundstrom, J.; Korhonen, E.; Luis, A. S.; Bojar, D.

10.1101/2023.01.16.524336 — biochemistry — Posted on 2023-01-19

1910 QC-GN2oMS2: a Graph Neural Net for High Resolution Mass Spectra Prediction.

Overstreet, R. E.; King, E.; Nguyen, J.; Ciesielski, D.

10.1101/2023.01.16.524269 — biochemistry — Posted on 2023-01-19

1911 Designed active-site library reveals thousands of functional GFP variants

Weinstein, J. Y.; Aldaravi, C. M. G.; Lipsh-Sokolik, R.; Hoch, S. Y.; Liebermann, D.; Nevo, R.; Weissman, H.; Petrovich-Kopitman, E.; Margulies, D.; Ivankov, D.; McCandlish, D.; Fleishman, S. J.

10.1101/2022.10.11.511732 — biochemistry — Posted on 2023-01-19

1912 Use of multimodal sensory cues in predator avoidance by wild-caught zebrafish shoals

Mukherjee, I.; Malakar, A.; Das, D.; Bhat, A.

10.1101/2023.01.16.524267 — animal behavior and cognition — Posted on 2023-01-19

1913 Colonization of a novel host plant reduces phenotypic variation

Nilsson, K. J.; Tsuboi, M.; Opedal, O.; Runemark, A.

10.1101/2023.01.16.524271 — evolutionary biology — Posted on 2023-01-19

1914 Development of a soil inoculation method coupled with blocker-mediated 16S rRNA gene amplicon sequencing reveals the effect of antibacterial T6SS on agrobacteria tumorigenesis and gallobiome composition

Wang, S.-C.; Chen, A.-P.; Chou, S.-J.; Kuo, C. H.; Lai, E.-M.

10.1101/2022.10.28.514271 — microbiology — Posted on 2023-01-19

1915 Mucins shed from the laminated layer in cystic echinococcosis are captured by Kupffer cells via the lectin receptor Clec4F

Barrios, A. A.; Mouhape, C.; Schreiber, L.; Nell, J.; Suarez-Martins, M.; Schlapp, G.; Meikle, M. N.; Mulet, A. P.; Hsu, T.-L.; Hsieh, S.-L.; Mourglia-Ettlin, G.; Gonzalez, C.; Crispo, M.; Barth, T. F. E.; Casaravilla, C.; Jenkins, S. J.; Diaz, A.

10.1101/2022.10.06.511139 — immunology — Posted on 2023-01-19

1916 Exosome based multivalent vaccine: achieving potent immunization, broadened reactivity, and strong T cell responses with nanograms of proteins

Cacciottolo, M.; Nice, J. B.; Li, Y.; LeClaire, M. J.; Twaddle, R.; Mora, C. L.; Adachi, S. Y.; Chin, E. R.; Young, M.; Angeles, J.; Elliott, K.; Sun, M.

10.1101/2023.01.10.523356 — immunology — Posted on 2023-01-19

1917 A call to rethink the cognitive benefits of physical exercise

Ciria, L. F.; Romn-Caballero, R.; Vadillo, M. A.; Holgado, D.; Luque-Casado, A.; Perakakis, P.; Sanabria, D.

10.1101/2022.02.15.480508 — neuroscience — Posted on 2023-01-19

1918 G-quadruplex DNA structures mediate non-autonomous instruction of breast tumour microenvironments

Hunold, P.; Hoehne, M. N.; Kiljan, M.; van Ray, O.; Herter, J.; Herter-Sprie, G. S.; Haensel-Hertsch, R.

10.1101/2023.01.16.524243 — cancer biology — Posted on 2023-01-19

1919 Systematic microRNA screening identifies miR-19b as regulator of temozolomide response through targeting PP2A serine-threonine phosphatase in glioblastoma

Kashani, E.; Hlavackova, K.; Haemmig, S.; Sadowski, M. C.; Phour, J.; Baumgartner, U.; Mueller-Wirth, N.; Trefny, C.; Sharf Den Abu Fakher, B.; Nydegger, C.; Maragkou, T.; Schucht, P.; Zinn, P.; Luedi, M.; Marti, T. M.; Krebs, P.; Vassella, E.

10.1101/2023.01.16.524069 — cancer biology — Posted on 2023-01-19

1920 PacBio Hi-Fi genome assembly of the Iberian dolphin freshwater mussel Unio delphinus Spengler, 1793

Gomes-dos-Santos, A.; Lopes-Lima, M.; Machado, A. M.; Teixeira, A.; Castro, L. F. C.; Froufe, E.

10.1101/2023.01.16.524251 — bioinformatics — Posted on 2023-01-19

1921 Large-scale in-cell photocrosslinking at single residue resolution reveals the molecular basis for glucocorticoid receptor regulation by immunophilins

Baischew, A.; Engel, S.; Geiger, T. M.; Hausch, F.

10.1101/2023.01.16.524346 — biochemistry — Posted on 2023-01-19

1922 Extrinsic mortality and senescence: a guide for the perplexed

de Vries, C. d.; Galipaud, M.; Kokko, H.

10.1101/2022.01.27.478060 — evolutionary biology — Posted on 2023-01-19

1923 Cerebellar-driven cortical dynamics enable task acquisition, switching and consolidation

Pemberton, J.; Chadderton, P.; Costa, R. P.

10.1101/2022.11.14.516257 — neuroscience — Posted on 2023-01-19

1924 Natural variability in bee brain size and symmetry revealed by micro-CT imaging and deep learning

Lösel, P. D.; Monchanin, C.; Lebrun, R.; Jayme, A.; Relle, J.; Devaud, J.-M.; Heuveline, V.; Lihoreau, M.

10.1101/2022.10.12.511944 — animal behavior and cognition — Posted on 2023-01-19

1925 N-terminal proteoforms may engage in different protein complexes

Bogaert, A.; Fijalkowska, D.; Staes, A.; Van de Steene, T.; Vuylsteke, M.; Stadler, C.; Eyckerman, S.; Spirohn, K.; Hao, T.; Calderwood, M. A.; Gevaert, K.

10.1101/2023.01.17.524352 — systems biology — Posted on 2023-01-19

1926 The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors

Bressendorff, S.; Kausika, S.; Sjogaard, I. M. Z.; Oksbjerg, E.; Michels, A.; Poulsen, C.; Brodersen, P.

10.1101/2023.01.18.524620 — molecular biology — Posted on 2023-01-19

1927 Distinction between small RNA-bound and free ARGONAUTE via an N-terminal protein-protein interaction site

Bressendorff, S.; Sjogaard, I. M. Z.; Prestel, A.; Kragelund, B. B.; Poulsen, C.; Brodersen, P.

10.1101/2022.10.22.513346 — molecular biology — Posted on 2023-01-19

1928 Redox-active compound generated by bacterial crosstalk induces hypha branching in Streptomyces species

Kato, M.; Asamizu, S.; Onaka, H.

10.1101/2023.01.12.523877 — microbiology — Posted on 2023-01-19

1929 Cortical projection to the pedunculopontine nucleus subpopulation for the Go/STOP signal modulation of muscle tone and locomotion

Dautan, D.

10.1101/2023.01.05.522181 — neuroscience — Posted on 2023-01-19

1930 A profile likelihood-based workflow for identifiability analysis, estimation, and prediction with mechanistic mathematical models

Simpson, M. J.; Maclaren, O. J.

10.1101/2022.12.14.520367 — systems biology — Posted on 2023-01-19

1931 The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma

Wilson, N. G.; Hernandez-Leyva, A.; Schwartz, D. J.; Bacharier, L. B.; Kau, A.

10.1101/2023.01.03.522677 — genomics — Posted on 2023-01-19

1932 High-throughput sequencing of macaque basolateral amygdala projections reveals dissociable connectional motifs with frontal cortex

Zeisler, Z. R.; London, L.; Janssen, W. G.; Fredericks, J. M.; Elorette, C.; Fujimoto, A.; Zhan, H.; Russ, B. E.; Clem, R. L.; Hof, P. R.; Stoll, F. M.; Rudebeck, P. H.

10.1101/2023.01.18.524407 — neuroscience — Posted on 2023-01-18

1933 Microscopic Imaging of Epigenetic Age

Rodriguez, D.; Alvarez-Kuglen, M.; Qin, H.; Fiengo, L.; Farhy, C.; Havas, A.; Hsu, W.-M.; Anderson, R. M.; Adams, P. D.; Sharpee, T. O.; Terskikh, A.

10.1101/2022.10.16.512441 — systems biology — Posted on 2023-01-18

1934 The telegraph process is not a subordinator

Gorin, G.; Pachter, L.

10.1101/2023.01.17.524309 — biophysics — Posted on 2023-01-18

1935 Improving the predictive performance of CLUE-S by extending demand to land transitions: the trans-CLUE-S model

Kiziridis, D. A.; Mastrogianni, A.; Pleniou, M.; Tsiftsis, S.; Xystrakis, F.; Tsiripidis, I.

10.1101/2023.01.10.523486 — ecology — Posted on 2023-01-18

1936 Normative modeling of brain morphometry in Clinical High-Risk for Psychosis

Haas, S. S.; Ge, R.; Agartz, I.; Amminger, G. P.; Andreassen, O. A.; Bachman, P.; Baeza, I.; Choi, S.; Colibazzi, T.; Cropley, V. L.; de la Fuente-Sandoval, C.; Ebdrup, B. H.; Fortea, A.; Fusar-Poli, P.; Glenthoj, B. Y.; Glenthoj, L. B.; Haut, K. M.; Hayes, R. A.; Heekeren, K.; Hooker, C. I.; Hwang, W. J.; Jahanshad, N.; Kaess, M.; Kasai, K.; Katagiri, N.; Kim, M.; Kindler, J.; Koike, S.; Kristensen, T. D.; Kwon, J. S.; Lawrie, S. M.; Lee, J.; Lemmers-Jansen, I. L.; Lin, A.; Ma, X.; Mathalon, D. H.; McGuire, P.; Michel, C.; Mizrahi, R.; Mizuno, M.; Moller, P.; Mora-Duran, R.; Nelson, B.; Nemot

10.1101/2023.01.17.523348 — neuroscience — Posted on 2023-01-18

1937 Excitation and inhibition delays within a feedforward inhibitory pathway modulate cerebellar Purkinje cell output in mice

Binda, F.; Spaeth, L.; Kumar, A.; Isope, P.

10.1101/2023.01.18.524515 — neuroscience — Posted on 2023-01-18

1938 L-type Ca2+ channels mediate regulation of glutamate release by subthreshold potential changes

Lee, B. J.; Lee, U.; Ryu, S. H.; Han, S.; Lee, S. Y.; Lee, J. S.; Ju, A.; Chang, S.; Lee, S.-H.; Kim, S. H.; Ho, W.-K.

10.1101/2023.01.18.524500 — neuroscience — Posted on 2023-01-18

1939 Sex differences in pain: Spinal cord injury in female and male mice elicits behaviors related to neuropathic pain

Lee, S. E.; Greenough, E. K.; Oancea, P.; Scheinfeld, A. R.; Douglas, A. M.; Gaudet, A. D.

10.1101/2022.10.18.512805 — neuroscience — Posted on 2023-01-18

1940 Preserved functional organization of human auditory cortex in individuals missing one temporal lobe from infancy

Regev, T. I.; Lipkin, B.; Boebinger, D. L.; Paunov, A. M.; Kean, H.; Norman-Haignere, S. V.; Fedorenko, E.

10.1101/2023.01.18.523979 — neuroscience — Posted on 2023-01-18

1941 Medial entorhinal cortex plays a specialized role in learning of flexible, context-dependent interval timing behavior

Bigus, E. R.; Lee, H.-W.; Shi, J.; Heys, J. G.

10.1101/2023.01.18.524598 — neuroscience — Posted on 2023-01-18

1942 Human-derived cortical neurospheroids coupled to passive, high-density and 3D MEAs: a valid platform for functional tests

Muzzi, L.; Di Lisa, D.; Falappa, M.; Pepe, S.; Maccione, A.; Pastorino, L.; Martinoia, S.; Frega, M.

10.1101/2023.01.17.524439 — bioengineering — Posted on 2023-01-18

1943 Extensive characterization of a Williams Syndrome murine model shows Gtf2ird1-mediated rescue of select sensorimotor tasks, but no effect on enhanced social behavior

Dougherty, J. D.; Nygaard, K. R.; Maloney, S. E.; Swift, R. G.; McCullough, K. B.; Wagner, R. E.; Fass, S. B.; Garbett, K.; Mirnics, K.; Veenstra-VanderWeele, J.

10.1101/2023.01.18.523029 — animal behavior and cognition — Posted on 2023-01-18

1944 A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer's disease

Boeddrich, A.; Haenig, C.; Neuendorf, N.; Blanc, E.; Ivanov, A.; Kirchner, M.; Schleumann, P.; Bayraktaroglu, I.; Richter, M.; Molenda, C. M.; Sporbert, A.; Zenkner, M.; Schnoegl, S.; Suenkel, C.; Schneider, L.-S.; Rybak-Wolf, A.; Kochnowsky, B.; Byrne, L. M.; Wild, E. J.; Nielsen, J. E.; Dittmar, G.; Peters, O.; Beule, D.; Wanker, E. E.

10.1101/2023.01.16.523715 — molecular biology — Posted on 2023-01-18

1945 GeneVector: Identification of transcriptional programs using dense vector representations defined by mutual information.

Ceglia, N.; Sethna, Z.; Freeman, S. S.; Uhlitz, F.; Bojilova, V.; Rusk, N.; Burman, B.; Chow, A.; Salehi, S.; Kabeer, F.; Aparicio, S. H.; Greenbaum, B. D.; Shah, S. P.; McPherson, A.

10.1101/2022.04.22.487554 — bioinformatics — Posted on 2023-01-18

1946 Time distributed data analysis by Cosinor.Online application

Molcan, L.

10.1101/805960 — bioinformatics — Posted on 2023-01-18

1947 Gene Trajectory Inference for Single-cell Data by Optimal Transport Metrics

Qu, R.; Cheng, X.; Sefik, E.; Platt, S.; Garritano, J.; Odell, I.; Flavell, R.; Myung, P.; Kluger, Y.

10.1101/2022.07.08.499404 — bioinformatics — Posted on 2023-01-18

1948 Phylogenetic and biogeographical traits predict unrecognized hosts of zoonotic leishmaniasis

Glidden, C. K.; Murran, A.; Silva, R. A.; Castellanos, A. A.; Han, B. A.; Mordecai, E. A.

10.1101/2022.10.11.511693 — ecology — Posted on 2023-01-18

1949 Distinction between small RNA-bound and free ARGONAUTE via an N-terminal protein-protein interaction site

Bressendorff, S.; Sjogaard, I. M. Z.; Prestel, A.; Kragelund, B. B.; Poulsen, C.; Brodersen, P.

10.1101/2022.10.22.513346 — molecular biology — Posted on 2023-01-18

1950 Distinct chromatin scanning modes lead to targeting of compacted chromatin by pioneer factors FOXA1 and SOX2

Lerner, J.; Katznelson, A.; Zhang, J.; Zaret, K. S.

10.1101/2022.12.22.521655 — molecular biology — Posted on 2023-01-18

1951 DksA homologs, ppGpp and RegAB regulate dissimilatory nitrogen metabolism in Paracoccus denitrificans

Ray, A.; Spiro, S.

10.1101/2023.01.17.523660 — microbiology — Posted on 2023-01-18

1952 Enhanced survival and low proliferation marks multifunctional virus specific memory CD4 T cells

Westerhof, L. M.; Noonan, J.; Hargrave, K. E.; Chimbayo, E. T.; Cheng, Z.; Purnell, T.; Jackson, M. R.; Borcherding, N.; MacLeod, M. K.

10.1101/2022.12.13.520219 — immunology — Posted on 2023-01-18

1953 Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and rescue by risperidone

Delgado-Sallent, C.; Gener, T.; Nebot, P.; Lopez-Cabezon, C.; Puig, M. V.

10.1101/2023.01.16.524241 — neuroscience — Posted on 2023-01-18

1954 Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression

Sanda, P.; Hlinka, J.; van den Berg, M.; Bazhenov, M.; Keliris, G. A.; Krishnan, G.

10.1101/2022.11.01.514686 — neuroscience — Posted on 2023-01-18

1955 The locus of recognition memory signals in human cortex depends on the complexity of the memory representations

Sanders, D. M. W.; Cowell, R. A.

10.1101/2021.06.15.448519 — neuroscience — Posted on 2023-01-18

1956 Ubiquitous lognormal distribution of neuron densities across mammalian cerebral cortex

Morales-Gregorio, A.; van Meegen, A.; van Albada, S. J.

10.1101/2022.03.17.480842 — neuroscience — Posted on 2023-01-18

1957 Variations in ERP Data Quality Across Paradigms, Participants, and Scoring Procedures

Zhang, G.; Luck, S. J.

10.1101/2022.08.22.504647 — neuroscience — Posted on 2023-01-18

1958 CRISPR/Cas9-mediated disruption of CjACOS5 confers no-pollen formation on sugi trees (Cryptomeria japonica D. Don)

Nishiguchi, M.; Futamura, N.; Endo, M.; Mikami, M.; Toki, S.; Katahata, S.-I.; Ohmiya, Y.; Konagaya, K.-i.; Nanasato, Y.; Taniguchi, T.; Maruyama, T. E.

10.1101/2023.01.16.521755 — plant biology — Posted on 2023-01-18

1959 ARAX: a graph-based modular reasoning tool for translational biomedicine

Glen, A. K.; Ma, C.; Mendoza, L.; Womack, F.; Wood, E. C.; Sinha, M.; Acevedo, L.; Kvarfordt, L. G.; Peene, R. C.; Liu, S.; Hoffman, A. S.; Roach, J. C.; Deutsch, E. W.; Ramsey, S. A.; Koslicki, D.

10.1101/2022.08.12.503810 — bioinformatics — Posted on 2023-01-18

1960 Heterogeneous pseudobulk simulation enables realistic benchmarking of cell-type deconvolution methods

Hu, M.; Chikina, M.

10.1101/2023.01.05.522919 — bioinformatics — Posted on 2023-01-18

1961 Deep Neural Networks Predict MHC-I Epitope Presentation and Transfer Learn Neoepitope Immunogenicity

Albert, B. A.; Yang, Y.; Shao, X. M.; Singh, D.; Smith, K. N.; Anagnostou, V.; Karchin, R.

10.1101/2022.08.29.505690 — bioinformatics — Posted on 2023-01-18

1962 CanSig: discovery of shared transcriptional states across cancer patients from single-cell RNA sequencing data

Yates, J.; Barkmann, F.; Czyz, P.; Kraft, A.; Glettig, M.; Lohmann, F.; Saquand, E.; von der Horst, R.; Volken, N.; Beerenwinkel, N.; Boeva, V.

10.1101/2022.04.14.488324 — bioinformatics — Posted on 2023-01-18

1963 Unmixing Fluorescence Image Data with Sparse and Low-Rank Poisson Regression

Wang, R.; Lemus, A. A.; Henneberry, C. M.; Ying, Y.; Feng, Y.; Valm, A. M.

10.1101/2023.01.06.523044 — bioinformatics — Posted on 2023-01-18

1964 Persistent homology analysis distinguishes pathological bone microstructure in non-linear microscopy images

Pritchard, Y.; Sharma, A.; Clarkin, C.; Ogden, H.; Mahajan, S.; Garcia, R. J. S.

10.1101/2022.07.19.500658 — bioinformatics — Posted on 2023-01-18

1965 Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer

Choi, S.; Whitman, M. A.; Shimpi, A. A.; Sempertegui, N. D.; Chiou, A.; Druso, J. E.; Verma, A.; Lux, S. C.; Cheng, Z.; Paszek, M.; Elemento, O.; Estroff, L. A.; Fischbach, C.

10.1101/2022.06.29.498001 — bioengineering — Posted on 2023-01-18

1966 Analysis and Comparison of Methods for Determining Motor Threshold with Transcranial Magnetic Stimulation

Wang, B.; Peterchev, A. V.; Goetz, S. M.

10.1101/2022.06.26.495134 — bioengineering — Posted on 2023-01-18

1967 Performance and limitations of linkage-disequilibrium-basedmethods for inferring the genomic landscape of recombination anddetecting hotspots: a simulation study

Raynaud, M.; Gagnaire, P.-A.; Galtier, N.

10.1101/2022.03.30.486352 — genomics — Posted on 2023-01-18

1968 Phylogenetic modeling of enhancer shifts in African mole-rats reveals regulatory changes associated with tissue-specific traits

Parey, E.; Frost, S.; Uribarren, A.; Park, T. J.; Zoettl, M.; Smith, E. S. J.; Berthelot, C.; Villar Lozano, D.

10.1101/2023.01.10.523217 — genomics — Posted on 2023-01-18

1969 Recombination between heterologous human acrocentric chromosomes

Guarracino, A.; Buonaiuto, S.; Gomes de Lima, L.; Potapova, T.; Rhie, A.; Koren, S.; Rubinstein, B.; Fischer, C.; Human Pangenome Reference Consortium, ; Gerton, J. L.; Phillippy, A. M.; Colonna, V.; Garrison, E.

10.1101/2022.08.15.504037 — genomics — Posted on 2023-01-18

1970 DNMT3B PWWP mutations cause hypermethylation of heterochromatin

Taglini, F.; Kafetzopoulos, I.; Musialik, K. I.; Lee, H. Y.; Zhang, Y.; Marenda, M.; Kerr, L.; Finan, H.; Rubio-Ramon, C.; Wapenaar, H.; Davidson-Smith, H.; Wills, J.; Murphy, L. C.; Wheeler, A.; Wilson, M. D.; Sproul, D.

10.1101/2022.12.19.521050 — genetics — Posted on 2023-01-18

1971 Parametric effects of light acting via multiple photoreceptors contribute tocircadian entrainment in Drosophila melanogaster.

Abhilash, L.; Shafer, O. T.

10.1101/2022.03.02.482722 — genetics — Posted on 2023-01-18

1972 Loops and the activity of loop extrusion factors constrain chromatin dynamics

Bailey, M. L. P.; Surovtsev, I. V.; Williams, J. F.; Yan, H.; Yuan, T.; Li, K.; Duseau, K.; Mochrie, S.; King, M. C.

10.1101/2020.02.29.969683 — cell biology — Posted on 2023-01-18

1973 PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size

Sobajima, T.; Kowalczyk, K.; Skylakakis, S.; Hayward, D.; Fulcher, L. J.; Neary, C.; Batley, C.; Kurlekar, S.; Roberts, E.; Gruneberg, U.; Barr, F. A.

10.1101/2022.05.23.492953 — cell biology — Posted on 2023-01-18

1974 A novel TGF-β-responsive enhancer regulates SRC expression and epithelial-mesenchymal transition-associated cell migration

Noshita, S.; Kubo, Y.; Kajiwara, K.; Okuzaki, D.; Nada, S.; Okada, M.

10.1101/2022.11.25.517908 — molecular biology — Posted on 2023-01-18

1975 Tryptophan-like side chain holding aptamers inhibit respiratory syncytial virus infection of lung epithelial cells

Percze, K.; Tolnai, Z. J.; Eleveld, M.; Ou, L.; Du, H.; Olia, A. S.; Kwong, P. D.; de Jonge, M. I.; Meszaros, T.

10.1101/2022.12.09.519757 — molecular biology — Posted on 2023-01-18

1976 Lysine-deficient proteome can be regulated through non-canonical ubiquitination and ubiquitin-independent proteasomal degradation

Szulc, N. A.; Piechota, M.; Thapa, P.; Pokrzywa, W.

10.1101/2023.01.18.524605 — molecular biology — Posted on 2023-01-18

1977 A glycine zipper motif governs translocation of type VI secretion toxic effectors across the cytoplasmic membrane of target cells

Ali, J.; Yu, M.; Sung, L.-K.; Cheung, Y. W.; Lai, E.-M.

10.1101/2022.07.12.499750 — microbiology — Posted on 2023-01-18

1978 The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus

Li, T. M.; Zyulina, V.; Seltzer, E. S.; Dacic, M.; Chinenov, Y.; Daamen, A.; Veiga, K. R.; Schwartz, N.; Oliver, D. J.; Lora, J.; Jabbari, A.; Liu, Y.; Shipman, W. D.; Ambler, W. G.; Taber, S. F.; Onel, K. B.; Zippin, J. H.; Rashighi, M.; Krueger, J. G.; Anandasabapathy, N.; Rogatsky, I.; Blobel, C. P.; Lipsky, P. E.; Lu, T. T.

10.1101/2021.08.18.456792 — immunology — Posted on 2023-01-18

1979 Functionally dissecting claustrum along anterior-posterior axis in anxiety and higher sensitivity to cocaine

Zhao, Z.; Liu, Z.; Chen, L.; Chen, W.; Guo, H.; Wang, J.; Mai, Y.; Wei, X.; Ding, J.; Ge, F.; Fan, Y.; Guan, X.

10.1101/2022.12.30.522289 — neuroscience — Posted on 2023-01-18

1980 Pallidal neuromodulation of the explore/exploit trade-off in decision-making

de Almeida Marcelino, A.; Gray, O.; Al-Fatly, B.; Gilmour, W.; Steele, D.; Kuhn, A.; Gilbertson, T.

10.1101/2022.04.21.489010 — neuroscience — Posted on 2023-01-18

1981 Tunable control of insect pheromone biosynthesis in Nicotiana benthamiana

Kallam, K.; Moreno Gimenez, E.; Mateos Fernandez, R.; Tansley, C.; Gianoglio, S.; Orzaez, D.; Patron, N. J.

10.1101/2022.06.15.496242 — synthetic biology — Posted on 2023-01-18

1982 Gene complementation analysis suggests that dodder plants (Cuscuta spp.) do not depend on the host FT protein for flowering

Mäckelmann, S.; Känel, A.; Kösters, L. M.; Lyko, P.; Prüfer, D.; Noll, G. A.; Wicke, S.

10.1101/2022.12.19.520981 — plant biology — Posted on 2023-01-18

1983 Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states

Al-Dalahmah, O.; Argenziano, M.; Kannan, A.; Mahajan, A.; Furnari, J.; Paryani, F.; Boyett, D.; Save, A.; Humala, N.; Khan, F.; Li, J.; Lu, H.; Sun, Y.; Tuddenham, J.; goldberg, a. r.; Dovas, A.; Banu, M.; Sudhakar, T.; Bush, E.; Lassman, A.; McKhann, G. M.; Gill, B. J. A.; Youngerman, B.; Sisti, M. B.; Bruce, J.; Sims, P.; Menon, V.; Canoll, P.

10.1101/2021.07.06.451295 — pathology — Posted on 2023-01-18

1984 A biomechanical model for the relation between bite force and mandibular opening angle in arthropods

Puffel, F.; Johnston, R. E.; Labonte, D.

10.1101/2022.08.17.504316 — biophysics — Posted on 2023-01-18

1985 Comparison of cell response to chromatin and DNA damage

Luzhin, A.; Rajan, P.; Safina, A.; Leonova, Y.; Stablewski, A.; Wang, J.; Kantidze, O.; Gurova, K.

10.1101/2023.01.17.524424 — molecular biology — Posted on 2023-01-18

1986 Alternative splicing of the stress-sensitive regulator CIRBP sharpens the cellular response to bacterial infection

Corre, M.; Boehm, V.; Besic, V.; Kurowska, A.; Viry, A.; Mohammad, A.; Semanaud-Beaufort, C.; Thomas-Chollier, M.; Lebreton, A.

10.1101/2023.01.18.524578 — molecular biology — Posted on 2023-01-18

1987 HuR inhibition reduces post-ischemic cardiac remodeling by dampening acute inflammatory gene expression and the innate immune response

Slone, S.; Anthony, S. R.; Green, L. C.; Nieman, M. L.; Alam, P.; Wu, X.; Roy, S.; Aube, J.; Xu, L.; Lorenz, J. N.; Owens, A. P.; Kanisicak, O.; Tranter, M.

10.1101/2023.01.17.524420 — molecular biology — Posted on 2023-01-18

1988 A chemical probe to modulate human GID4 Pro/N-degron interactions

Owens, D. D. G.; Maitland, M. E. R.; Khalili Yazdi, A.; Song, X.; Schwalm, M. P.; Machado, R. A. C.; Bauer, N.; Wang, X.; Szewczyk, M. M.; Dong, C.; Dong, A.; Loppnau, P.; Calabrese, M.; Dowling, M. S.; Lee, J.; Montgomery, J. I.; O'Connell, T. N.; Subramanyam, C.; Wang, F.; Schapira, M.; Knapp, S.; Vedadi, M.; Min, J.; Lajoie, G. A.; Barsyte-Lovejoy, D.; Owen, D. R.; Schild-Poulter, C.; Arrowsmith, C. H.

10.1101/2023.01.17.524225 — molecular biology — Posted on 2023-01-18

1989 The BR-body proteome contains a complex network of protein-protein and protein-RNA interactions

Nandana, V.; Rathnayaka-Mudiyanselage, I. W.; Muthunayake, N. S.; Hatami, A.; Mousseau, C. B.; Ortiz-Rodriguez, L. A.; Vaishnav, J.; Collins, M.; Gega, A.; Mallikaarachchi, K. S.; Yassine, H.; Ghosh, A.; Biteen, J. S.; Zhu, Y.; Champion, M. M.; Childers, W. S.; Schrader, J. M.

10.1101/2023.01.18.524314 — microbiology — Posted on 2023-01-18

1990 Insulin-mediated endothelin signaling is antiviral during West Nile virus infection

Trammell, C. E.; Rowe, E. H.; Jones, B. J.; Char, A. B.; Fawcett, S.; Ahlers, L. R. H.; Goodman, A. G.

10.1101/2023.01.17.524426 — microbiology — Posted on 2023-01-18

1991 CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway

Green, L. R.; Issa, R.; Albaldi, F.; Urwin, L.; Khalid, H.; Turner, C. E.; Ciani, B.; Partridge, L. J.; Monk, P. N.

10.1101/2023.01.17.524294 — microbiology — Posted on 2023-01-18

1992 Bioengineering of a Lactococcus lactis subsp. lactis strain enhances nisin production and bioactivity.

Portieles, R.; Xu, H.; Chen, F.; Gao, J.; Du, C.; Gao, X.; Nordelo, C. B.; Yue, Q.; Zhao, L.; Gonzalez, N. P.; Bermudez, R. S.; Borras-Hidalgo, O.

10.1101/2023.01.18.524535 — microbiology — Posted on 2023-01-18

1993 Isolation and genomic and physiological characterization of Parageobacillus sp. G301, the isolate capable of both hydrogenogenic and aerobic carbon monoxide oxidation

Imaura, Y.; Okamoto, S.; Hino, T.; Ogami, Y.; Katayama, Y. A.; Tanimura, A.; Inoue, M.; Kamikawa, R.; Yoshida, T.; Sako, Y.

10.1101/2023.01.17.524042 — microbiology — Posted on 2023-01-18

1994 Engineering a Scalable and Orthogonal Platform for Synthetic Communication in Mammalian Cells

Pistikou, A.-M. M.; Cremers, G.; Nathalia, B.; Bogels, B.; Eijkens, B.; de Dreu, A.; Bezembinder, M.; Stassen, O.; Bouten, C.; Merkx, M.; Jerala, R.; de Greef, T.

10.1101/2023.01.18.524631 — synthetic biology — Posted on 2023-01-18

1995 COL7A1 expression improves prognosis prediction for patients with clear cell renal cell carcinoma atop of stage

Koca, D.; Seraudie, I.; Jardiller, R.; Cochet, C.; Filhol, O.; Guyon, L.

10.1101/2023.01.16.524247 — cancer biology — Posted on 2023-01-18

1996 A Cost-effective Purification Process for Erythropoietin Biosimilar through Downstream Process Engineering

Nag, K.; Sarker, M. E. H.; Kumar, S.; Chakraborty, S.; Khan, H.; Islam, M. J.; Khan, M. M. R.; Chowdhury, M. M. R.; Roy, R.; Roy, R.; Biswas, B. K.; Bappi, M. E. H.; Mohiuddin, M.; Sultana, N.

10.1101/2023.01.18.524508 — bioengineering — Posted on 2023-01-18

1997 Structure and DNA bridging activity of the essential Rec114-Mei4 trimer interface

Liu, K.; Grasso, E. M.; Pu, S.; Eliezer, D.; Liu, S.; Keeney, S.

10.1101/2023.01.18.524603 — biochemistry — Posted on 2023-01-18

1998 Comparative analysis of chemical cross-linking mass spectrometry data indicates that protein STY residues rarely react with N-hydroxysuccinimide ester cross-linkers

Cao, Y.; Liu, X.-T.; Mao, P.-Z.; Tarn, C.; Dong, M.-Q.

10.1101/2023.01.17.524485 — biochemistry — Posted on 2023-01-18

1999 Biochemical and structural characterisation of a family GH5 cellulase from endosymbiont of shipworm P. megotara

Junghare, M.; Manavalan, T.; Fredriksen, L.; Leiros, I.; Altermark, B.; G.H. Eijsink, V.; Vaaje-Kolstad, G.

10.1101/2023.01.17.521928 — biochemistry — Posted on 2023-01-18

2000 Bioorthogonal chemical labelling of endogenous neurotransmitter receptors in living mouse brains

Nonaka, H.; Sakamoto, S.; Shiraiwa, K.; Ishikawa, M.; Tamura, T.; Okuno, K.; Kiyonaka, S.; Susaki, E. A.; Shimizu, C.; Ueda, H. R.; Kakegawa, W.; Arai, I.; Yuzaki, M.; Hamachi, I.

10.1101/2023.01.16.524180 — biochemistry — Posted on 2023-01-18

2001 Genome diversity of Leishmania aethiopica

Hadermann, A.; Heeren, S.; Maes, I.; Dujardin, J.-C.; Domagalska, M. A.; Van den Broeck, F.

10.1101/2023.01.17.524362 — genomics — Posted on 2023-01-18

2002 Geographic migration and vaccine-induced fitness changes of Streptococcus pneumoniae

Belman, S.; Lefrancq, N.; Nzenze, S. A.; Downs, S. L.; du Plessis, M.; Lo, S. W.; The Global Pneumococcal Sequencing Consortium, ; Mcgee, L.; Madhi, S. A.; von Gottberg, A.; Bentley, S. D.; Salje, H.

10.1101/2023.01.18.524577 — evolutionary biology — Posted on 2023-01-18

2003 Morphological changes and two Nodal paralogs drive left-right asymmetry in the squamate veiled chameleon (C. calyptratus).

Shylo, N.; Smith, S. E.; Price, A.; Guo, F.; McClain, M.; Trainor, P.

10.1101/2023.01.18.524635 — developmental biology — Posted on 2023-01-18

2004 Structural basis of peptide recognition and activation of endothelin receptors

Ji, Y.; Duan, J.; Yuan, Q.; He, X.; Yang, G.; Zhu, S.; Wu, K.; Hu, W.; Gao, T.; Cheng, X.; Jiang, H.; Xu, H. E.; Jiang, Y.

10.1101/2023.01.17.524465 — molecular biology — Posted on 2023-01-18

2005 DYRK1A interacts with Tuberous Sclerosis complex and promotes mTORC1 activity

Wang, P.; Sarkar, S.; Zhang, M.; Zhang, Z.; Datta, S.; Jayaram, N.; Datta, S.; He, R.; Wu, P.; Chao, P.; Zhang, Y.; Washburn, M. P.; Florens, L.; Nagarkar, S.; Jaiswal, M.; Mohan, M.

10.1101/2023.01.18.524493 — molecular biology — Posted on 2023-01-18

2006 Impact of the yeast S0/uS2-cluster ribosomal protein rpS21/eS21 on rRNA folding and the architecture of small ribosomal subunit precursors

Poell, G.; Tschochner, H.; Griesenbeck, J.; Milkereit, P.

10.1101/2023.01.18.524556 — molecular biology — Posted on 2023-01-18

2007 Probing the sub-cellular mechanisms of LCA5-Leber Congenital Amaurosis and associated gene therapy with expansion microscopy

Faber, S.; Mercey, O.; Junger, K.; Garanto, A.; Ueffing, M.; Collin, R. W. J.; Boldt, K.; Guichard, P.; Hamel, V.; Roepman, R.

10.1101/2023.01.17.524360 — molecular biology — Posted on 2023-01-18

2008 The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors

Bressendorff, S.; Kausika, S.; Sjogaard, I. M. Z.; Oksbjerg, E.; Michels, A.; Poulsen, C.; Brodersen, P.

10.1101/2023.01.18.524620 — molecular biology — Posted on 2023-01-18

2009 Treponema pallidum subsp. pallidum with an Artificially Impaired TprK Antigenic Variation System is Attenuated in the Rabbit Model of Syphilis

Romeis, E.; Lieberman, N. A. P.; Molini, B. J.; Tantalo, L. C.; Chung, B.; Phung, Q.; Avendano, C.; Vorobieva, A.; Greninger, A. L.; Giacani, L.

10.1101/2023.01.18.524629 — microbiology — Posted on 2023-01-18

2010 Globoside and the mucosal pH mediate parvovirus B19 entry through the epithelial barrier

Suter, C.; Colakovic, M.; Bieri, J.; Gultom, M.; Dijkman, R.; Ros, C.

10.1101/2023.01.18.524533 — microbiology — Posted on 2023-01-18

2011 Proline catabolism is key to facilitating Candida albicans pathogenicity

Silao, F. G. S.; Jiang, T.; Bereczky-Veress, B.; Kuehbacher, A.; Ryman, K.; Uwamohoro, N.; Jenull, S.; Nogueira, F.; Ward, M.; Lion, T.; Urban, C. F.; Rupp, S.; Kuchler, K.; Chen, C.; Peuckert, C.; Ljungdahl, P. O.

10.1101/2023.01.17.524449 — microbiology — Posted on 2023-01-18

2012 Metagenomic analysis of ecological niche overlap and community collapse in microbiome dynamics

Fujita, H.; Ushio, M.; Suzuki, K.; Abe, M. S.; Yamamichi, M.; Okazaki, Y.; Canarini, A.; Hayashi, I.; Fukushima, K.; Fukuda, S.; Kiers, T.; Toju, H.

10.1101/2023.01.17.524457 — microbiology — Posted on 2023-01-18

2013 VAP spatially stabilizes dendritic mitochondria to locally fuel synaptic plasticity

Bapat, O.; Purimetla, T.; Kruessel, S.; Thum, C.; Rupprecht, F.; Shah, M.; Langer, J. D.; Rangaraju, V.

10.1101/2023.01.16.524245 — neuroscience — Posted on 2023-01-18

2014 Modulatory Effect of Levodopa on the Basal Ganglia-Cerebellum Connectivity in Parkinson's Disease

Abulikemu, S.; Tai, Y. F.; Haar, S.

10.1101/2023.01.16.524229 — neuroscience — Posted on 2023-01-18

2015 Gaze patterns and brain activations in humans and marmosets in the Frith-Happe; theory-of-mind animation task

Dureux, A.; Zanini, A.; Selvanayagam, J.; Menon, R. S.; Everling, S.

10.1101/2023.01.16.524238 — neuroscience — Posted on 2023-01-18

2016 Astrocyte and neuronal Panx1 support long-term reference memory in mice

Obot, P.; Subah, G.; Schonwald, A.; Pan, J.; Velisek, L.; Veliskova, J.; Stanton, P. K.; Scemes, E.

10.1101/2023.01.16.524236 — neuroscience — Posted on 2023-01-18

2017 Model-guided Design of Biological Controller for Septic Wound Healing Regulation

Green, L.; Naghshnejad, P.; Dankwa, D.; Tang, X.

10.1101/2023.01.16.523937 — systems biology — Posted on 2023-01-18

2018 A partially shared joint clustering framework for detecting protein complexes from multiple state-specific signed interaction networks

Zhan, Y.; Liu, J.; Wu, M.; Tan, C. S. H.; Li, X.; Ou-Yang, L.

10.1101/2023.01.16.524205 — bioinformatics — Posted on 2023-01-18

2019 Dual Adversarial Deconfounding Autoencoder for joint batch-effects removal from multi-center and multi-scanner radiomics data

Cavinato, L.; Massi, M. C.; Sollini, M.; Kirienko, M.; Ieva, F.

10.1101/2023.01.16.524181 — bioinformatics — Posted on 2023-01-18

2020 Fatty liver-mediated glycine restriction impairs glutathione synthesis and causes hypersensitization to acetaminophen

Ghrayeb, A.; Agranovich, B.; Peled, D.; Finney, A. C.; Abramovitch, I.; Fernandez Garcia, J.; Traylor, J. G.; Drucker, S.; Fernandes, S. I.; Weissman, N.; Chen, Y. E.; Rom, O.; Mor, I.; Gottlieb, E.

10.1101/2023.01.16.524043 — biochemistry — Posted on 2023-01-18

2021 Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

Zhang, S. M.; Paulin, C. B.; Michel, M.; Marttila, P.; Yagüe-Capilla, M.; Bwanika, H. C.; Shu, H.; Papagudi Vekatram, R.; Wiita, E.; Jemth, A.-S.; Almlöf, I.; Loseva, O.; Ortis, F.; Dirks, C.; Koolmeister, T.; Linde, E.; Lee, S.; Llona-Minguez, S.; Haraldsson, M.; Strömberg, K.; Homan, E. J.; Scobie, M.; Lundbäck, T.; Helleday, T.; Rudd, S. G.

10.1101/2023.01.17.524275 — biochemistry — Posted on 2023-01-18

2022 Mechanical models affecting beetle horn remodeling

Matsuda, K.; Adachi, H.; Gotoh, H.; Inoue, Y.; Kondo, S.

10.1101/2023.01.16.524208 — developmental biology — Posted on 2023-01-18

2023 Efficient chemical and enzymatic syntheses of FAD nucleobase analogues and their analysis as enzyme cofactors

Shah, A.; Kumar, Y.; Rohan, S.; Hazra, A. B.

10.1101/2023.01.16.524199 — molecular biology — Posted on 2023-01-18

2024 Fcgamma-receptor-independent controlled activation of CD40 canonical signaling by novel therpeutic antibodies for cancer therapy

Reitinger, C.; Beckmann, K.; Carle, A.; Bluemle, E.; Jurkschat, N.; Paulmann, C.; Prassl, S.; Kazandijan, L.; Nimmerjahn, F.; Fischer, S.

10.1101/2023.01.16.521736 — immunology — Posted on 2023-01-18

2025 Estimating the energy requirements for long term memory formation

Girard, M.; Jiang, J.; van Rossum, M. C.

10.1101/2023.01.16.524203 — neuroscience — Posted on 2023-01-18

2026 Sex differences in neurotransmitter levels in different brain regions after acute and chronic morphine treatment in mice

Gabel, F.; Hovhannisyan, V.; Berkati, A.-K.; ANDRY, V.; Goumon, Y.

10.1101/2023.01.16.524193 — neuroscience — Posted on 2023-01-18

2027 MRI-assessed locus coeruleus contrast and functional response are not associated in young and late middle-aged individuals

Berger, A.; Koshmanova, E.; Beckers, E.; Sharifpour, R.; Paparella, I.; Campbell, I.; Mortazavi, N.; Balda, F.; Yi, Y.-J.; Lamalle, L.; Dricot, L.; Phillips, C.; Jacobs, H.; Talwar, P.; El Tahry, R.; Sherif, S.; Vandewalle, G.

10.1101/2023.01.16.524213 — neuroscience — Posted on 2023-01-18

2028 Astrocytic control of extra-cellular GABA drives circadian time-keeping in the suprachiasmatic nucleus

Patton, A. P.; Morris, E. L.; McManus, D.; Wang, H.; Li, Y.; Chin, J. W.; Hastings, M. H.

10.1101/2023.01.16.523253 — neuroscience — Posted on 2023-01-18

2029 Morphological profiling by cell painting in human neural progenitor cells classifies hit compounds in a pilot drug screen for Alzheimer's disease

McDiarmid, A. H.; Gospodinova, K. O.; Elliott, R. J.; Dawson, J. C.; Hughes, R. E.; Anderson, S. M.; Glen, S. C.; Glerup, S.; Carragher, N. O.; Evans, K. L.

10.1101/2023.01.16.523559 — neuroscience — Posted on 2023-01-18

2030 Functional specialization and structured representations for space and time in prefrontal cortex

Bohm, C.; Lee, A. K.

10.1101/2023.01.16.524214 — neuroscience — Posted on 2023-01-18

2031 Smart utilization of betaine lipids in giant clam Tridacna crocea

Sakai, R.; Goto-Inoue, N.; Yamashita, H.; Aimoto, N.; Kitai, Y.; Maruyama, T.

10.1101/2023.01.16.524159 — zoology — Posted on 2023-01-18

2032 Self-supervised vision transformers accurately decode cellular state heterogeneity

Pfaendler, R.; Hanimann, J.; Lee, S.; Snijder, B.

10.1101/2023.01.16.524226 — systems biology — Posted on 2023-01-18

2033 N-terminal proteoforms may engage in different protein complexes

Bogaert, A.; Fijalkowska, D.; Staes, A.; Van de Steene, T.; Vuylsteke, M.; Stadler, C.; Eyckerman, S.; Spirohn, K.; Hao, T.; Calderwood, M. A.; Gevaert, K.

10.1101/2023.01.17.524352 — systems biology — Posted on 2023-01-18

2034 Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

Song, F.; Lee, W. D.; Marmo, T.; Ji, X.; Song, C.; Liao, X.; Seeley, R.; Yao, L.; Liu, H.; Long, F.

10.1101/2023.01.16.524248 — physiology — Posted on 2023-01-18

2035 A Network-based Transcriptomic Landscape of HepG2 cells to Uncover Causal Gene Cytotoxicity Interactions Underlying Drug-Induced Liver Injury

Wijaya, L.; Gabor, A.; Pot, I.; der Have, L. v.; Saez-Rodriguez, J.; Stevens, J. L.; Le Devedec, S. E.; Callegaro, G.; de Water, B. v.

10.1101/2023.01.16.524182 — pharmacology and toxicology — Posted on 2023-01-18

2036 Oncogenic GNAS uses PKA-dependent and independent mechanisms to induce cell proliferation in human pancreatic ductal and acinar organoids

Desai, R.; Muthuswamy, S. K.

10.1101/2023.01.16.524220 — cancer biology — Posted on 2023-01-18

2037 Volumetric refractive index measurement and quantitative density analysis of mouse brain tissue with sub-micrometer spatial resolution

Lee, A. J.; Kim, Y. S.; Kim, J.-G.; Hugonnet, H.; Lee, M.; Ku, T.; Park, Y.

10.1101/2023.01.16.524195 — biophysics — Posted on 2023-01-18

2038 Ankh : Optimized Protein Language Model Unlocks General-Purpose Modelling

Elnaggar, A.; Essam, H.; Salah-Eldin, W.; Moustafa, W.; Elkerdawy, M.; Rochereau, C.; Rost, B.

10.1101/2023.01.16.524265 — bioinformatics — Posted on 2023-01-18

2039 Caution Regarding the Specificities of Pan-Cancer Microbial Structure

Gihawi, A.; Brewer, D. S.; Cooper, C. S.

10.1101/2023.01.16.523562 — bioinformatics — Posted on 2023-01-18

2040 Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

Potalitsyn, P.; Mrazkova, L.; Selicharova, I.; Tencerova, M.; Ferencakova, M.; Chrudinova, M.; Brzozowski, A. M.; Marek, A.; Kaminsky, J.; Jiracek, J.; Zakova, L.

10.1101/2023.01.16.524179 — biochemistry — Posted on 2023-01-18

2041 Alternative equations and "pseudo-statistical" approaches that enhance the precision of initial rates for the determination of kinetic parameters

Udema, I. I.

10.1101/2023.01.16.524223 — biochemistry — Posted on 2023-01-18

2042 Covalent inhibition by a natural product-inspired latent electrophile

Byun, D. P.; Ritchie, J.; Holewinski, R.; Kim, H.-R.; Tagirasa, R.; Ivanic, J.; Weekley, C. M.; Parker, M. W.; Adresson, T.; Yoo, E.

10.1101/2023.01.16.524242 — biochemistry — Posted on 2023-01-18

2043 Developmental diet alters the fecundity-longevity relationship and age-related gene expression in Drosophila melanogaster

Collins, D. H.; Prince, D. C.; Donelan, J. L.; Chapman, T.; Bourke, A. F. G.

10.1101/2023.01.16.524185 — evolutionary biology — Posted on 2023-01-18

2044 A macroevolutionary role for chromosomal fusion and fission in Erebia butterflies

Augustijnen, H.; Baetscher, L.; Cesanek, M.; Chkhartishvili, T.; Dinca, V.; Iankoshvili, G.; Ogawa, K.; Vila, R.; Klopfstein, S.; de Vos, J.; Lucek, K.

10.1101/2023.01.16.524200 — evolutionary biology — Posted on 2023-01-18

2045 VICTORY for Cryo-EM: Ultra-High Atomic Resolution Cryo-EM Structure of β-Galactosidase at 1.1 A

Chakraborty, A.

10.1101/2023.01.08.522890 — molecular biology — Posted on 2023-01-18

2046 The chromatin modulating NSL complex regulates genes and pathways genetically linked to Parkinsons disease

Hicks, A. R.; Reynolds, R. H.; O'Callaghan, B.; Garcia Ruiz, S.; Gil Martinez, A. L.; Botia, J. A.; Plun-Favreau, H.; Ryten, M.

10.1101/2023.01.16.523926 — neuroscience — Posted on 2023-01-18

2047 A deep generative model of the SARS-CoV-2 spike protein predicts future variants

Dhodapkar, R. M.

10.1101/2023.01.17.524472 — bioinformatics — Posted on 2023-01-18

2048 Discovery of highly potent small molecule pan-coronavirus fusion inhibitors

Curreli, F.; Chau, K.; Tran, T.-T.; Nicolau, I.; Ahmed, S.; Das, P.; Hillyer, C. D.; Premenko-Lanier, M.; Debnath, A. K.

10.1101/2023.01.17.524492 — pharmacology and toxicology — Posted on 2023-01-18

2049 A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease

Geng, Z. Z.; Atla, S.; Shaabani, N.; Vulupara, V. R.; Yang, K. S.; Alugubelli, Y. R.; Khatua, K.; Chen, P.-H. C.; Xiao, J.; Blankenship, L. R.; Ma, X. R.; Vatansever, E. C.; Cho, C.-C.; Ma, Y.; Allen, R.; Ji, H.; Xu, S.; Liu, W. R.

10.1101/2023.01.17.524469 — biochemistry — Posted on 2023-01-18

2050 Cell division tracing combined with single-cell transcriptomics reveals new cell types and differentiation paths in the regenerating mouse lung

Martins, L. R.; Sieverling, L.; Michelhans, M.; Schiller, C.; Erkut, C.; Triana, S.; Froehling, S.; Velten, L.; Glimm, H.; Scholl, C.

10.1101/2023.01.18.524384 — cell biology — Posted on 2023-01-18

2051 Higher Angiotensin I Converting Enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer's disease.

Reveret, L.; Leclerc, M.; Emond, v.; Loiselle, A.; Philippe, B.; Tremblay, C.; Bennett, D. A.; Hebert, S. S.; Calon, F. S.

10.1101/2023.01.17.524254 — neuroscience — Posted on 2023-01-18

2052 Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.

Aguado, J.; Amarilla, A. A.; Taherian Fard, A.; Albornoz, E. A.; Tyshkovskiy, A.; Schwabenland, M.; Chaggar, H.; Modhiran, N.; Gomez-Inclan, C.; Javed, I.; Baradar, A.; Liang, B.; Dharmaratne, M.; Pietrogrande, G.; Padmanabhan, P.; Freney, M.; Parry, R.; Sng, J.; Isaacs, A.; Khromykh, A.; Rojas-Fernandez, A.; Davis, T.; Prinz, M.; Bengsch, B.; Gladyshev, V. N.; Woodruff, T. M.; Mar, J. C.; Watterson, D.; Wolvetang, E. J.

10.1101/2023.01.17.524329 — neuroscience — Posted on 2023-01-18

2053 Benchmarking of analytical combinations for COVID-19 outcome prediction using single-cell RNA sequencing data

Cao, Y.; Ghazanfar, S.; Yang, P.; Yang, J.

10.1101/2023.01.18.524481 — bioinformatics — Posted on 2023-01-18

2054 Ontogenesis of the molecular response to sleep loss

Muheim, C. M.; Ford, K. E.; Medina, E.; Singletary, K. G.; Peixoto, L.; Frank, M. G.

10.1101/2023.01.16.524266 — neuroscience — Posted on 2023-01-18

2055 Resolving the haplotypes of arbuscular mycorrhizal fungi highlights the role of two nuclear populations in host interactions

Sperschneider, J.; Yildirir, G.; Malar C, M.; Ariane Mayrand Nicol, A.; Sorwar, E.; Chen, E. C.; Brauer, E. K.; Bosnich, W.; Corradi, N.

10.1101/2023.01.15.524138 — genomics — Posted on 2023-01-18

2056 Multiple pals gene modules control a balance between immunity and development in Caenorhabditis elegans

Lazetic, V.; Blanchard, M. J.; Bui, T.; Troemel, E. R.

10.1101/2023.01.15.524171 — immunology — Posted on 2023-01-18

2057 Improved cognitive-motor processing speed and decreased functional connectivity after high intensity aerobic exercise in individuals with chronic stroke

Andrushko, J. W.; Rinat, S.; Greeley, B.; Larssen, B. C.; Jones, C. B.; Rubino, C.; Denyer, R.; Ferris, J.; Campbell, K. L.; Neva, J. L.; Boyd, L. A.

10.1101/2023.01.15.523513 — neuroscience — Posted on 2023-01-18

2058 Increased mitochondrial surface area and cristae density in the skeletal muscle of strength athletes

Botella, J.; Schytz, C. T.; Pehrson, T. F.; Hokken, R.; Laugesen, S.; Aagaard, P.; Suetta, C.; Christensen, B.; Ortenblad, N.; Nielsen, J.

10.1101/2023.01.15.524144 — physiology — Posted on 2023-01-18

2059 PeruNPDB: The Peruvian Natural Products Database for in silico drug screening

Barazorda-Ccahuana, H. L.; Galvez Ranilla, L.; Candia-Puma, M. A.; Carcamo-Rodriguez, E. G.; Centeno-Lopez, A. E.; Davila Del-Carpio, G.; Medina-Franco, J. L.; Chavez-Fumagalli, M. A.

10.1101/2023.01.15.524152 — bioinformatics — Posted on 2023-01-18

2060 G3DC: a Gene-Graph-Guided selective Deep Clustering method for single cell RNA-seq data

He, S.; Yu, T.; Fan, J.

10.1101/2023.01.15.524109 — bioinformatics — Posted on 2023-01-18

2061 Linear versus Nonlinear Muscle Networks: A Case Study to Decode Hidden Synergistic Patterns During Dynamic Lower-limb Tasks

O'Keeffe, R.; Rathod, V.; Shirazi, S. Y.; Mehrdad, S.; Edwards, A.; Rao, S.; Atashzar, S. F.

10.1101/2023.01.15.524160 — bioengineering — Posted on 2023-01-18

2062 Trans-Acting Genotypes Drive mRNA Expression Affecting Metabolic And Thermal Tolerance Traits

Drown, M.; Oleksiak, M.; Crawford, D.

10.1101/2023.01.15.524165 — genetics — Posted on 2023-01-18

2063 AliSim-HPC: parallel sequence simulator for phylogenetics

Ly-Trong, N.; M.J. Barca, G.; Minh, B. Q.

10.1101/2023.01.15.524158 — evolutionary biology — Posted on 2023-01-18

2064 ChipFilter: Microfluidic Based Comprehensive Sample Preparation Methodology for Metaproteomics

Ravi Kumar, R. K.; Ndiaye, M. M.; Haddad, I.; Vinh, J.; Verdier, Y.

10.1101/2023.01.18.524548 — biochemistry — Posted on 2023-01-18

2065 Illumination of the complement receptors C3aR and C5aR signaling by anaphylatoxins

Wang, Y.; Zhuang, Y.; Xu, E. H.; Liu, W.; Xu, Y.; Yuan, Q.; He, X.; Luo, P.; Fan, W.; Zhu, J.; Zhang, X.; Cheng, X.; Jiang, Y.

10.1101/2023.01.18.524551 — biochemistry — Posted on 2023-01-18

2066 Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern

Frasson, I.; Diamante, L.; Zangrossi, M.; Carbognin, E.; Dalla Pieta, A.; Penna, A.; Rosato, A.; Verin, R.; Torrigiani, F.; Salata, C.; Vaccaro, L.; Cacchiarelli, D.; Richter, S. N.; Montagner, M.; Martello, G.

10.1101/2023.01.09.523209 — microbiology — Posted on 2023-01-18

2067 Dynamics of Innate Immune Response Due to Bacteria-Induced Pulpitis

Erdogan, O.; Xia, J.; Chiu, I. M.; Gibbs, J. L.

10.1101/2023.01.15.524125 — immunology — Posted on 2023-01-18

2068 High-throughput quantification of camelid cytokine mRNA expression in PBMCs by microfluidic qPCR technology

Rodon, J.; Te, N.; Ballester, M.; Segales, J.; Vergara-Alert, J.; Bensaid, A.

10.1101/2023.01.15.524100 — immunology — Posted on 2023-01-18

2069 Circuit and cell-specific contributions to decision making involving risk of explicit punishment in male and female rats.

Truckenbrod, L. M.; Betzhold, S. M.; Wheeler, A.-R.; Shallcross, J.; Singhal, S.; Harden, S.; Schwendt, M.; Frazier, C. J.; Bizon, J. L.; Setlow, B.; Orsini, C. A.

10.1101/2023.01.15.524142 — neuroscience — Posted on 2023-01-18

2070 Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming

Yang, J.; Tang, R.; Chen, S.; Chen, Y.; Zhang, L.; Yuan, K.; Huang, R.; Wang, L.

10.1101/2023.01.15.524137 — neuroscience — Posted on 2023-01-18

2071 Dissecting the Functional Organization of the C. elegans Serotonergic System at Whole-Brain Scale

Dag, U.; Nwabudike, I.; Kang, D.; Gomes, M. A.; Kim, J.; Atanas, A. A.; Bueno, E.; Estrem, C.; Pugliese, S.; Wang, Z.; Towlson, E.; Flavell, S. W.

10.1101/2023.01.15.524132 — neuroscience — Posted on 2023-01-18

2072 Early root phenotyping in sweetpotato (Ipomoea batatas L.) uncovers insights into root system architecture variability

Duque, L. O.

10.1101/2023.01.18.524552 — plant biology — Posted on 2023-01-18

2073 An efficient context-aware approach for whole slide image classification

Shen, H.; Wu, J.; Shen, X.; Hu, J.; Liu, J.; Zhang, Q.; Sun, Y.; Chen, K.; Li, X.

10.1101/2023.01.15.524098 — pathology — Posted on 2023-01-18

2074 Deciphering the phenotypic heterogeneity and drug response in cancer cells using genome-wide activity and interaction of chromatin domains.

Pandey, N.; Sharma, M.; Mathur, A.; Nzelu, G. A.; Hakimullah, M.; Jha, I. P.; Chandra, O.; Mishra, S.; Sharma, A.; Foo, R.; Mandoli, A.; DasGupta, R.; KUMAR, V.

10.1101/2023.01.15.524115 — cancer biology — Posted on 2023-01-18

2075 RNA sequencing identifies lung cancer lineage and facilitates drug repositioning

Zeng, L.; Zhang, L.; Li, L.; Liao, X.; Yin, C.; Zhang, L.; Chen, X.; Sun, J.

10.1101/2023.01.18.524544 — cancer biology — Posted on 2023-01-18

2076 Multiple conformational states assembly of multidomain proteins using evolutionary algorithm based on structural analogues and sequential homologues

Peng, C.; Zhou, X.; Liu, J.; Hou, M.; Li, S. Z.; Zhang, G.

10.1101/2023.01.15.524086 — bioinformatics — Posted on 2023-01-18

2077 Reliable genetic correlation estimation via multiple sample splitting and smoothing

Mai, T. T.

10.1101/2023.01.15.524097 — bioinformatics — Posted on 2023-01-18

2078 AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics

Mongia, A.; Saunders, D.; Wang, Y.; Brissova, M.; Powers, A. C.; Kaestner, K. H.; Vahedi, G.; Naji, A.; Schwartz, G.; Faryabi, R. B.

10.1101/2023.01.15.524135 — bioinformatics — Posted on 2023-01-18

2079 Deep Learning Dynamic Allostery of G-Protein-Coupled Receptors

Do, H. N.; Wang, J.; Miao, Y.

10.1101/2023.01.15.524128 — bioinformatics — Posted on 2023-01-18

2080 Cultivation of Ulva sp. offshore the Eastern Mediterranean Sea in experimental bioreactors: seasonal growth dynamics and environmental effects

Zollmann, M.; Liberzon, A.; Palatnik, R. R.; Zilberman, D.; Golberg, A.

10.1101/2023.01.15.524102 — bioengineering — Posted on 2023-01-18

2081 NGS method for parallel processing of high quality, damaged or fragmented input material using target enrichment

Lyander, A.; Gellerbring, A.; Hagglund, M.; Elhami, K.; Wirta, V.

10.1101/2023.01.15.524106 — genomics — Posted on 2023-01-18

2082 Pilot Analysis of Genetic Effects on Personality Test Scores with AI: ABO Blood Type in Japan

Kanazawa, M.

10.1101/2023.01.15.524099 — genetics — Posted on 2023-01-18

2083 Genotype-specific variation in seasonal body condition at a large-effect maturation locus

House, A. H.; Debes, P. V.; Kurko, J.; Erkinaro, J.; Primmer, C. R.

10.1101/2023.01.15.524064 — evolutionary biology — Posted on 2023-01-18

2084 A century of sampling at an ecological preserve reveals declining diversity of wild bees

Graham, K. K.; Glaum, P.; Hartert, J.; Gibbs, J.; Tucker, E.; Isaacs, R.; Valdovinos, F. S.

10.1101/2023.01.15.524123 — ecology — Posted on 2023-01-18

2085 Terrestrial laser scan metrics predict surface vegetation biomass and consumption in a frequently burned southeastern U.S. ecosystem

Loudermilk, E. L.; Pokswinski, S.; Hawley, C. M.; Maxwell, A.; Gallagher, M. R.; Skowronski, N. S.; Hudak, A. T.; Hoffman, C.; Hiers, J. K.

10.1101/2023.01.15.524107 — ecology — Posted on 2023-01-18

2086 Sustained Selective Attention in Adolescence: Cognitive Development and Predictors of Distractibility at School

Hobbiss, M.; Lavie, N.

10.1101/2023.01.15.523576 — developmental biology — Posted on 2023-01-18

2087 Reduced glycolysis links resting zone chondrocyte proliferation in the growth plate

Kobayashi, T.; Young, C. J.; Zhou, W.; Rhee, E. P.

10.1101/2023.01.18.524550 — developmental biology — Posted on 2023-01-18

2088 Nucleoside Diphosphate Kinases 1 and 2 regulate a protective liver response to a high-fat diet

Iuso, D.; Garcia-Saez, I.; Coute, Y.; Yamaryo-Botte, Y.; Erba, E. B.; Adrait, A.; Zeaiter, N.; Tokarska-Schlattner, M.; Jilkova, Z. M.; Boussouar, F.; Barral, S.; Signor, L.; Couturier, K.; Hajmirza, A.; Chuffart, F.; Vitte, A.-L.; Bargier, L.; Puthier, D.; Decaens, T.; Rousseaux, S.; Botte, C. Y.; Schlattner, U.; Petosa, C.; Khochbin, S.

10.1101/2023.01.15.524116 — molecular biology — Posted on 2023-01-18

2089 Tobramycin adaptation alters the antibiotic susceptibility of Pseudomonas aeruginosa quorum sensing-null mutants

Abisado-Duquea, R. G.; McKee, B. M.; Townsend, K. A.; Woods, K.; Holder, A. J.; Craddock, V. D.; Cabeen, M. T.; Chandler, J. R.

10.1101/2023.01.13.523864 — microbiology — Posted on 2023-01-18

2090 Gastrodin ameliorates synaptic impairment, reestablishes mitochondrial membrane potential and reduces oxidative stress in N2a/APP cells through the ERK1/2 and GSK-3beta pathways

Tang, Z.; Peng, Y.; Wang, L.; Guo, M.; Chen, Z.; Zhang, T.; Xiao, Y.; Ni, R.; Qi, X.

10.1101/2023.01.15.524095 — neuroscience — Posted on 2023-01-18

2091 If it's there, could it be a bear?

Foxon, F.

10.1101/2023.01.14.524058 — zoology — Posted on 2023-01-18

2092 Predicting Human Bioavailability of Subcutaneously Administered Fusion Proteins and Monoclonal Antibodies

Zou, P.

10.1101/2023.01.15.524112 — pharmacology and toxicology — Posted on 2023-01-18

2093 Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19.

Clark, J. J.; Penrice-Randal, R.; Sharma, P.; Kipar, A.; Dong, X.; Pennington, S.; Marriott, A. E.; Colombo, S.; Davidson, A. D.; Kavanagh Williamson, M.; Matthews, D. A.; Turtle, L.; Prince, T.; Hughes, G.; Patterson, E. I.; Shawli, G.; Subramaniam, K.; Sharp, J.; McLaughlin, L.; Zhou, E.-M.; Turner, J. D.; Biagini, G.; Owen, A.; Hiscox, J. A.; Stewart, J. P.

10.1101/2020.10.13.334532 — microbiology — Posted on 2023-01-18

2094 Analysis of cell death induction by the barley NLR immune receptor PBR1

Jaiswal, N.; Myers, A.; Weese, T.; Carter, M.; Scofield, S.; Helm, M.

10.1101/2023.01.15.524147 — plant biology — Posted on 2023-01-18

2095 Energetics of the Microsporidian Polar Tube Invasion Machinery

Chang, R.; Davydov, A.; Jaroenlak, P.; Budaitis, B.; Ekiert, D. C.; Bhabha, G.; Prakash, M.

10.1101/2023.01.17.524456 — biophysics — Posted on 2023-01-18

2096 Experimental Tests of the Virtual Circular Genome Model for Non-enzymatic RNA Replication

Ding, D.; Zhou, L.; Mittal, S.; Szostak, J. W.

10.1101/2023.01.16.524303 — biochemistry — Posted on 2023-01-18

2097 The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

Woodall, M.; Cujba, A.-M.; Worlock, K. B.; Case, K.-M.; Masonou, T.; Yoshida, M.; Polanski, K.; Huang, N.; Lindeboom, R. G.; Mamanova, L.; Bolt, L.; Richardson, L.; Ellis, S.; Palor, M.; Burgoyne, T.; Pinto, A.; Moulding, D. A.; McHugh, T. D.; Saleh, A.; Kilich, E.; Mehta, P.; O'Callaghan, C.; Zhou, J.; Barclay, W.; De Coppi, P.; Butler, C. R.; Vinette, H.; Roy, S.; Breuer, J.; Chambers, R. C.; Heywood, W. E.; Mills, K.; Hynds, R. E.; Teichmann, S. A.; Meyer, K. B.; Nikolic, M. Z.; Smith, C. M.

10.1101/2023.01.16.524211 — cell biology — Posted on 2023-01-18

2098 Genomic diversity of SARS-CoV-2 can be accelerated by mutations in the nsp14 gene

Takada, K.; Ueda, M. T.; Shichinohe, S.; Kida, Y.; Ono, C.; Matsuura, Y.; Watanabe, T.; Nakagawa, S.

10.1101/2020.12.23.424231 — microbiology — Posted on 2023-01-18

2099 Neurobehavioral precursors of compulsive cocaine-seeking in dual fronto-striatal circuits

Jones, J.; Belin-Rauscent, A.; Jupp, B.; Fouyssac, M.; Sawiak, S.; Zuhlsdorff, K.; Zhukovsky, P.; Hebon, L.; Velazquez, C.; Robbins, T.; Everitt, B. J.; Belin, D.; Dalley, J.

10.1101/2022.11.09.515779 — neuroscience — Posted on 2023-01-18

2100 Identification of basic helix-loop-helix transcription factors that activate betulinic acid biosynthesis by RNA-sequencing of hydroponically cultured Lotus japonicus

Suzuki, H.; Takahashi, H.; Fukushima, E. O.; Nakazono, M.; Muranaka, T.; Seki, H.

10.1101/2022.11.16.516519 — plant biology — Posted on 2023-01-18

2101 Biomimetic actin cortices shape cell-sized lipid vesicles

Baldauf, L.; Frey, F.; Perez, M. A.; Mladenov, M.; Way, M.; Idema, T.; Koenderink, G.

10.1101/2023.01.15.524117 — biophysics — Posted on 2023-01-18

2102 Autophagy mediates cancer cell resistance to doxorubicin induced by the Programmed Death 1/Programmed Death Ligand 1 immune checkpoint axis

Minassian, L.; Sanwalka, D.; Pare, J.-F.; Macdonald-Goodfellow, S.; Sutherland, R. L.; Ghaffari, A.; Margerum, C. L.; Koti, M.; Craig, A. W. B.; Cotechini, T.; Siemens, D. R.; Chan, E.; Graham, C. H.

10.1101/2023.01.17.524124 — cancer biology — Posted on 2023-01-18

2103 EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

10.1101/2023.01.15.524130 — cancer biology — Posted on 2023-01-18

2104 Knocking out alpha-synuclein in melanoma cells downregulates L1CAM and decreases motility

Gajendran, N.; Rajasekaran, S.; Witt, S. N.

10.1101/2023.01.17.524111 — cancer biology — Posted on 2023-01-18

2105 Allosteric communication induced by GTP binding sets off a closed-to-open transition in a bacterial dynamin-like protein

Schumann, W.; Strodel, B.

10.1101/2023.01.16.524228 — biophysics — Posted on 2023-01-18

2106 A multicolour polymer model for the prediction of 3D structure and transcription in human chromatin

Semeraro, M.; Negro, G.; Suma, A.; Gonnella, G.; Cook, P. R.; Marenduzzo, D.

10.1101/2023.01.16.524198 — biophysics — Posted on 2023-01-18

2107 Cryo-EM reveals the mechanism of DNA compaction by Mycobacterium smegmatis Dps2

Dutta, S.; Garg, P.; Ganji, M.; Satheesh, T.

10.1101/2023.01.16.523357 — biophysics — Posted on 2023-01-18

2108 In situ architecture of Opa1-dependent mitochondrial cristae remodeling

Fry, M. Y.; Navarro, P. P.; Qin, X.; Inde, Z.; Ananda, V. Y.; Lugo, C. M.; Hakim, P.; Luce, B. E.; Ge, Y.; McDonald, J. L.; Ali, I.; Ha, L. L.; Kleinstiver, B. P.; Chan, D. C.; Sarosiek, K.; Chao, L. H.

10.1101/2023.01.16.524176 — biophysics — Posted on 2023-01-18

2109 Nr5a2 is essential for morula development

Festuccia, N.; Vandormael-Pournin, S.; Chervova, A.; Geiselmann, A.-M.; Langa-Vives, F.; Coux, R.-X.; Gonzalez, I.; Cohen-Tannoudji, M.; Navarro, P.

10.1101/2023.01.16.524255 — developmental biology — Posted on 2023-01-18

2110 Coordinated multiple cellular processes in tongue development

Kawasaki, M.; Kawasaki, K.; Sari, F. T.; Kudo, T.; Nihara, J.; Kitamura, M.; Nagai, T.; Utama, V.; Ishida, Y.; Meguro, F.; Nishimura, T.; Kogure, Y.; Maruyama, S.; Tanuma, J.-i.; Kakihara, Y.; Maeda, T.; Ghafoor, S.; Khonsari, R. H.; Corre, P.; Sharpe, P. T.; Cobourne, M.; Franco, B.; Ohazama, A.

10.1101/2023.01.16.524234 — developmental biology — Posted on 2023-01-18

2111 p53 controls choice between apoptotic and non-apoptotic death following DNA damage

Honeywell, M. E.; Isidor, M. S. L.; Harper, N. W.; Fontana, R. E.; Cruz-Gordillo, P.; Porto, S. A.; Spinelli, J. B.; Guertin, D. A.; Lee, M. J.

10.1101/2023.01.17.524444 — cell biology — Posted on 2023-01-18

2112 The phospho-regulated amphiphysin/endophilin interaction is required for synaptic vesicle endocytosis

Kontaxi, C.; Cousin, M. A.

10.1101/2023.01.15.524101 — neuroscience — Posted on 2023-01-18

2113 The impact of modern admixture on archaic human ancestry in human populations

Witt, K. E.; Funk, A.; Lopez Fang, L.; Huerta-Sanchez, E.

10.1101/2023.01.16.524232 — genomics — Posted on 2023-01-18

2114 Migrating neurons adapt motility modes to brain microenvironments via a mechanosensor, PIEZO1

Nakazawa, N.; Grenci, G.; Kameo, Y.; Takeda, N.; Sawada, T.; Kurisu, J.; Zhejing, Z.; Adachi, T.; Nonomura, K.; Kengaku, M.

10.1101/2023.01.17.524464 — cell biology — Posted on 2023-01-18

2115 A controller-peripheral architecture and costly energy principle for learning

Luo, X.; Mok, R. M.; Roads, B. D.; Love, B. C.

10.1101/2023.01.16.524194 — neuroscience — Posted on 2023-01-18

2116 Maternal prenatal distress exposure negatively associates with the stability of neonatal frontoparietal network

Tuulari, J. J.; Rajasilta, O.; Cabral, J.; Kringelbach, M. L.; Karlsson, L.; Karlsson, H.

10.1101/2023.01.17.524480 — neuroscience — Posted on 2023-01-18

2117 Primate superior colliculus is engaged in abstract higher-order cognition

Peysakhovich, B.; Tetrick, S. M.; Silva, A. A.; Li, S.; Zhu, O.; Ibos, G.; Johnston, W. J.; Freedman, D. J.

10.1101/2023.01.17.524416 — neuroscience — Posted on 2023-01-18

2118 Dopamine enhances population coding of fear in prefrontal cortex.

Lesas, J.; Feugas, P.; Herry, C.; Dejean, C.

10.1101/2023.01.17.524376 — neuroscience — Posted on 2023-01-18

2119 An insular cortex to lateral amygdala pathway in fear learning

Palchaudhuri, S.; Osypenko, D.; Kochubey, O.; Schneggenburger, R.

10.1101/2023.01.17.524434 — neuroscience — Posted on 2023-01-18

2120 An updated C. elegans nuclear body muscle transcriptome for studies in muscle formation and function

Schorr, A. L.; Mejia, A. F.; Miranda, M. Y.; Mangone, M.

10.1101/2022.04.12.488068 — genetics — Posted on 2023-01-17

2121 Corynebacterium diphtheriae causes keratinocyte-intrinsic ribotoxic stress and NLRP1 inflammasome activation in a model of cutaneous diphtheria

ROBINSON, K. S.; TOH, G. A.; FIRDAUS, M. J.; THAM, K. C.; ROZARIO, P.; LIM, C.; TOH, Y. X.; LAU, Z. H.; BINDER, S. C.; MAYER, J.; BONNARD, C.; SCHMIDT, F. I.; COMMON, J. A.; ZHONG, F. L.

10.1101/2023.01.16.524188 — immunology — Posted on 2023-01-17

2122 Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonism Reduces Motion Sickness Indicators in Mouse Migraine Models

Rahman, S. M.; Luebke, A. E.

10.1101/2022.06.03.494762 — neuroscience — Posted on 2023-01-17

2123 High-fidelity reproduction of visual signals by electrical stimulation in the central primate retina

Gogliettino, A. R.; Madugula, S. S.; Grosberg, L. E.; Vilkhu, R. S.; Brown, J.; Nguyen, H.; Kling, A.; Hottowy, P.; Dabrowski, W.; Sher, A.; Litke, A. M.; Chichilnisky, E. J.

10.1101/2022.05.24.493162 — neuroscience — Posted on 2023-01-17

2124 Establishing And Maintaining The Blood-Brain Barrier: Epigenetic And Signaling Determinants.

Pandit, P. K. T.; Sadanandan, J.; Thomas, S.; Mathew, I. E.; Huang, Z.; Blackburn, S. L.; Tandon, N.; Lokhande, H.; McCrea, P. D.; Bresnick, E. H.; Dash, P. K.; McBride, D. W.; Harmanci, A.; Jose, D.; Dienel, A. C.; Zeineddine, H. A.; Hong, S.

10.1101/2022.11.29.516809 — neuroscience — Posted on 2023-01-17

2125 Virtual (Zoom) Interactions Alter Behavioral Cooperation and Dyadic Neural Coherence

Balters, S.; Miller, J. G.; Li, R.; Hawthorne, G. H.; Reiss, A. L.

10.1101/2022.06.03.494713 — neuroscience — Posted on 2023-01-17

2126 A novel micro-ECoG recording method for recording multisensory neural activity from the parietal to temporal cortices in mice

Setogawa, S.; Kanda, R.; Tada, S.; Hikima, T.; Saitoh, Y.; Ishikawa, M.; Nakada, S.; Seki, F.; Hikishima, K.; Matsumoto, H.; Mizuseki, K.; Fukayama, O.; Osanai, M.; Sekiguchi, H.; Ohkawa, N.

10.1101/2022.10.01.510247 — neuroscience — Posted on 2023-01-17

2127 Plant detection and counting from high-resolution RGB images acquired from UAVs: comparison between deep-learning and handcrafted methods with application to maize, sugar beet, and sunflower crops

David, E.; Daubige, G.; Joudelat, F.; Burger, P.; Comar, A.; De solan, B.; Baret, F.

10.1101/2021.04.27.441631 — plant biology — Posted on 2023-01-17

2128 Exploiting allele-specific transcriptional effects of subclonal copy number alterations for genotype-phenotype mapping in cancer cell populations

Shi, H.; Williams, M. J.; Satas, G.; Weiner, A. C.; McPherson, A.; Shah, S. P.

10.1101/2023.01.10.523464 — cancer biology — Posted on 2023-01-17

2129 Comparing the value of mono- versus coculture for high-throughput compound screening in hematological malignancies

Herbst, S. A.; Kim, V.; Roider, T.; Schitter, E. C.; Bruch, P.-M.; Liebers, N.; Kolb, C.; Knoll, M.; Lu, J.; Dreger, P.; Mueller-Tidow, C.; Zenz, T.; Huber, W.; Dietrich, S.

10.1101/2022.02.18.481065 — cancer biology — Posted on 2023-01-17

2130 Variational graph encoders: a surprisingly effective generalist algorithm for holistic computer-aided drug design

Lam, H. Y. I.; Pincket, R.; Han, H.; Ong, X. E.; Wang, Z.; Li, W.; Hinks, J.; Zheng, L.; Wei, Y.; Mu, Y.

10.1101/2023.01.11.523575 — bioinformatics — Posted on 2023-01-17

2131 Transcriptome sequencing suggests that pre-mRNAsplicing counteracts widespread intronic cleavage and polyadenylation

Vlasenok, M.; Margasyuk, S.; Pervouchine, D. D.

10.1101/2022.05.27.493724 — bioinformatics — Posted on 2023-01-17

2132 Tissue-specific regulation of gene expression via unproductive splicing

Mironov, A.; Vlasenok, M.; Margasyuk, S.; Mironov, A. A.; Pervouchine, D. D.

10.1101/2022.07.03.498634 — bioinformatics — Posted on 2023-01-17

2133 Bioregional boundaries and genomically-delineated stocks in snapper (Chrysophrys auratus) from southeastern Australia

Bertram, A.; Bell, J.; Brauer, C.; Fowler, A.; Hammer, P.; Sandoval-Castillo, J.; Stewart, J.; Wellenreuther, M.; Beheregaray, L. B.

10.1101/2023.01.16.524335 — genomics — Posted on 2023-01-17

2134 Ancient Clostridium DNA and variants of tetanus neurotoxins associated with human archaeological remains

Hodgins, H. P.; Chen, P.; Lobb, B.; Wei, X.; Tremblay, B. J.; Mansfield, M. J.; Lee, V. C.; Lee, P.-G.; Coffin, J.; Duggan, A. T.; Dolphin, A. E.; Renaud, G.; Dong, M.; Doxey, A. C.

10.1101/2022.06.30.498301 — genomics — Posted on 2023-01-17

2135 Strong interactions between highly-dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin

Tolokh, I. S.; Kinney, N. A.; Sharakhov, I. V.; Onufriev, A. V.

10.1101/2022.01.28.478236 — genomics — Posted on 2023-01-17

2136 The Foundational data initiative for Parkinsons disease (FOUNDIN-PD): enabling efficient translation from genetic maps to mechanism

Bressan, E.; Reed, X.; Bansal, V.; Hutchins, E.; Cobb, M. M.; Webb, M. G.; Alsop, E.; Grenn, F. P.; Illarionova, A.; Savytska, N.; Violich, I.; Broeer, S.; Fernandes, N.; Sivakumar, R.; Beilina, A.; Billingsley, K.; Berghausen, J.; Pantazis, C. B.; Pitz, V.; Patel, D.; Daida, K.; Meechoovet, B.; Reiman, R.; Courtright-Lim, A.; Logemann, A.; Antone, J.; Barch, M.; Kitchen, R.; Li, Y.; Dalgard, C. L.; The American Genome Center, ; Rizzu, P.; Hernandez, D. G.; Hjelm, B. E.; Nalls, M. A.; Gibbs, J. R.; Finkbeiner, S.; Cookson, M. R.; Van Keuren-Jensen, K.; Craig, D. W.; Singleton, A. B.; Heutink,

10.1101/2021.06.03.446785 — genomics — Posted on 2023-01-17

2137 Purging due to self-fertilization does not prevent accumulation of expansion load

Zeitler, L.; Parisod, C.; Gilbert, K. J.

10.1101/2022.12.19.521096 — evolutionary biology — Posted on 2023-01-17

2138 A fitness trade-off explains the early fate of yeast aneuploids with chromosome gains

Pompei, S.; Cosentino Lagomarsino, M.

10.1101/2022.07.07.499182 — evolutionary biology — Posted on 2023-01-17

2139 Phylogeographic breaks and how to find them: An empirical attempt at separating vicariance from isolation by distance in a lizard with restricted dispersal

Rancilhac, L.; Miralles, A.; Geniez, P.; Mendez-Aranda, D.; Beddek, M.; Brito, J. C.; Leblois, R.; Crochet, P.-A.

10.1101/2022.09.30.510256 — evolutionary biology — Posted on 2023-01-17

2140 Pollen-feeding delays reproductive senescence and maintains toxicity of Heliconius butterflies

Pinheiro de Castro, E. C.; McPherson, J.; Julian, G.; Mattila, A.; Bak, S.; Montgomery, S.; Jiggins, C.

10.1101/2023.01.13.523799 — evolutionary biology — Posted on 2023-01-17

2141 Potential future climate change effects on global reptile distributions and diversity

Biber, M. F.; Voskamp, A.; Hof, C.

10.1101/2022.05.07.490295 — ecology — Posted on 2023-01-17

2142 Individual reflectance of solar radiation confers a thermoregulatory benefit to dimorphic males bees (Centris pallida) using distinct microclimates

Barrett, M.; O'Donnell, S.

10.1101/2022.06.28.497958 — ecology — Posted on 2023-01-17

2143 A ligand-receptor interactome atlas of the zebrafish

Chodkowski, M.; Zielezinski, A.; Anbalagan, S.

10.1101/2022.12.15.520415 — developmental biology — Posted on 2023-01-17

2144 Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts

Yeung, C.-Y. C.; Garva, R.; Pickard, A.; Lu, Y.; Mallikarjun, V.; Swift, J.; Taylor, S. H.; Rai, J.; Eyre, D. R.; Chaturvedi, M.; Itoh, Y.; Meng, Q.-J.; Mauch, C.; Zigrino, P.; Kadler, K. E.

10.1101/2022.04.01.486699 — cell biology — Posted on 2023-01-17

2145 Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory programpredicted to correct glucose dysregulation

Tammineni, E. R.; Figueroa, L.; Manno, C.; Varma, D.; Kraeva, N.; Ibarra, C.; Riazi, S.; Klip, A.; Rios, E.

10.1101/2022.03.13.484107 — cell biology — Posted on 2023-01-17

2146 Deadenylation rate is not a major determinant of RNA degradation in yeast

Audebert, L.; Feuerbach, F.; Decourty, L.; Namane, A.; Permal, E.; Badis, G.; Saveanu, C.

10.1101/2023.01.16.524186 — molecular biology — Posted on 2023-01-17

2147 Ribosome rescue factor PELOTA modulates translation start site choice and protein isoform levels of transcription factor C/EBPα

Fernandez, S. G.; Ferguson, L.; Ingolia, N. T.

10.1101/2023.01.16.524343 — molecular biology — Posted on 2023-01-17

2148 Differential effects of pre-mRNA splicing inhibitors on RNA polymerase II transcription

Tellier, M.; Ansa, G.; Murphy, S.

10.1101/2023.01.16.524270 — molecular biology — Posted on 2023-01-17

2149 Predicting the efficacy of BH3 mimetics through the profiling of multiple protein complexes

Chun, C.; Byun, J. M.; Cha, M.; Lee, H.; Choi, B.; Kim, H.; Hong, S.; Lee, Y.; Park, H.; Koh, Y.; Yoon, T.-Y.

10.1101/2023.01.16.524337 — molecular biology — Posted on 2023-01-17

2150 Bidirectional regulation of postmitotic H3K27me3 distributions underlie cerebellar granule neuron maturation dynamics

Ramesh, V.; Liu, F.; Minto, M. S.; Chan, U.; West, A. E.

10.1101/2022.10.10.511582 — molecular biology — Posted on 2023-01-17

2151 The histone methyltransferase NSD3 contributes to sister chromatid cohesion and to cohesin loading during mitotic exit

EOT-HOULLIER, G.; MAGNAGHI-JAULIN, L.; BOURGINE, G.; SMAGULOVA, F.; GIET, R.; WATRIN, E.; JAULIN, C.

10.1101/2021.12.16.472961 — molecular biology — Posted on 2023-01-17

2152 Vancomycin resistance in Enterococcus faecium from the Dallas, Texas area is conferred predominantly on pRUM-like plasmids

Islam, M.; Sharon, B.; Abaragu, A.; Sistu, H.; Akins, R. L.; Palmer, K. L.

10.1101/2021.02.16.431552 — microbiology — Posted on 2023-01-17

2153 What humans learn from corrective feedback for perceptual decision-making

Lee, H.-J.; Lee, H.; Lim, C. Y.; Rhim, I.; Lee, S.-H.

10.1101/2023.01.11.523567 — neuroscience — Posted on 2023-01-17

2154 THINGS-data: A multimodal collection of large-scale datasets for investigating object representations in human brain and behavior

Hebart, M. N.; Contier, O.; Teichmann, L.; Rockter, A.; Zheng, C. Y.; Kidder, A.; Corriveau, A.; Vaziri-Pashkam, M.; Baker, C. I.

10.1101/2022.07.22.501123 — neuroscience — Posted on 2023-01-17

2155 Impaired polyamine metabolism causes behavioral and neuroanatomical defects in a novel mouse model of Snyder-Robinson Syndrome

Akinyele, O.; Kemaladewi, D. U.

10.1101/2023.01.15.524155 — neuroscience — Posted on 2023-01-17

2156 Systemic Calcitonin Gene-Related Peptide (CGRP) modifies auditory and vestibular endorgan electrical potentials, and increases auditory and vestibular hypersensitivities: Implications for vestibular migraine

Rahman, S. M.; Liang, B.; Faucher, S.; Fine, E.; Jonnala, R.; Holt, J. C.; Lee, C.; Luebke, A. E.

10.1101/2022.06.03.494764 — neuroscience — Posted on 2023-01-17

2157 Resurrection of plant disease resistance proteins via helper NLR bioengineering

Contreras, M. P.; Pai, H.; Selvaraj, M.; Toghani, A.; Lawson, D. M.; Tumtas, Y.; Duggan, C.; Yuen, E. L. H.; Stevenson, C. E. M.; Harant, A.; Maqbool, A.; Wu, C.-H.; Bozkurt, T. O.; Kamoun, S.; Derevnina, L.

10.1101/2022.12.11.519957 — plant biology — Posted on 2023-01-17

2158 Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators

Kline, G. M.; Paxman, R. J.; Lin, C.-Y.; Madrazo, N.; Grandjean, J. M.; Lee, K.; Nugroho, K.; Powers, E.; Wiseman, L.; Kelly, J. W.

10.1101/2023.01.16.524237 — biochemistry — Posted on 2023-01-17

2159 Genomic Landscape of Patients with Germline RUNX1 Variants and Familial Platelet Disorder with Myeloid Malignancies in a Natural History Study

Yu, K.; Deuitch, N.; Merguerian, M.; Cunningham, L.; Davis, J.; Bresciani, E.; Diemer, J.; Andrews, E.; Young, A.; Donovan, F.; Sood, R.; Craft, K.; Chong, S.; Chandrasekharappa, S.; Mullikin, J. C.; Liu, P. P.

10.1101/2023.01.17.524290 — genomics — Posted on 2023-01-17

2160 Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome

Feng, X.; Cui, X.; Zhang, L.-S.; Ye, C.; Wang, P.; Zhong, Y.; Zheng, Z.; He, C.

10.1101/2023.01.16.524325 — genetics — Posted on 2023-01-17

2161 Conditional, tissue-specific CRISPR/Cas9 vector system in zebrafish reveal the role of neuropilin-1b in heart regeneration

Mukhopadhyay, D.; Angom, R. S.; Wang, Y.; Wang, E.; Dutta, S.

10.1101/2023.01.16.524222 — molecular biology — Posted on 2023-01-17

2162 Histone acetylation insulator SET orchestrates PP2A inhibition and super-enhancer activation

Wu, D.; Xu, H.; Xu, J.; Lei, Y.; Lei, Y.; Yu, X.; Shi, S.

10.1101/2023.01.15.524091 — molecular biology — Posted on 2023-01-17

2163 Thor-Ribo-Seq: ribosome profiling tailored for low input with RNA-dependent RNA amplification

Mito, M.; Shichino, Y.; Iwasaki, S.

10.1101/2023.01.15.524129 — molecular biology — Posted on 2023-01-17

2164 m6A methylated long noncoding RNA regulates proinflammatory response emerging as novel target for IBD

Olazagoitia-Garmendia, A.; Rojas-Marquz, H.; Sebastian-delaCruz, M.; Ochoa, A.; Mendoza-Gomez, L. M.; Huerta, A.; Santin, I.; Castellanos-Rubio, A.

10.1101/2023.01.17.524371 — molecular biology — Posted on 2023-01-17

2165 Activation-induced cytidine deaminase-based in vivo continuous evolution system enables rapid protein engineering

Zhang, X.; Liu, Z.; Xu, Y.; Rao, D.; Chen, X.; Li, Z.; Huang, Y.; Wu, J.

10.1101/2023.01.17.524385 — molecular biology — Posted on 2023-01-17

2166 Specificity Guides Interpretation: On H3K4 Methylation at Enhancers and Broad Promoters

Shah, R. N.; Ruthenburg, A. J.

10.1101/2023.01.16.524067 — molecular biology — Posted on 2023-01-17

2167 In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming

Antunes, A. V.; Shahinas, M.; Swale, C.; Farhat, D. C.; Ramakrishnan, C.; Bruley, C.; Cannella, D.; Corrao, C.; Coute, Y.; Hehl, A. B.; Bougdour, A.; Coppens, I.; Hakimi, M.-a.

10.1101/2023.01.16.524187 — microbiology — Posted on 2023-01-17

2168 Cross-Species Protection to Innate Immunity Mediated by A Bacterial Pigment

Liu, Y.; McQuillen, E. A.; Rana, P. S. J. B.; Gloag, E. S.; Wozniak, D. J.

10.1101/2023.01.15.524085 — microbiology — Posted on 2023-01-17

2169 Establishment of a Mycoplasma hyorhinis challenge model in five-week-old piglets

Foldi, D.; Nagy, E. Z.; Belecz, N.; Szeredi, L.; Foldi, J.; Kollar, A.; Tenk, M.; Kreizinger, Z.; Gyuranecz, M.

10.1101/2023.01.17.524379 — microbiology — Posted on 2023-01-17

2170 DksA homologs, ppGpp and RegAB regulate dissimilatory nitrogen metabolism in Paracoccus denitrificans

Ray, A.; Spiro, S.

10.1101/2023.01.17.523660 — microbiology — Posted on 2023-01-17

2171 Aqueous Spice Extracts as Alternative Antimycotics to Control Highly Drug Resistant Extensive Biofilm Forming Clinical Isolates of Candida albicans

Sadanandan, B.; Vijayalakshmi, V.; Ashrit, P.; Babu, U. V.; Sharath Kumar, L. M.; Sampath, V.; Shetty, K.; Joglekar, A. P.; Awaknavar, R.

10.1101/2023.01.17.524370 — microbiology — Posted on 2023-01-17

2172 Patulin contamination of hard apple cider by Paecilomyces niveus and other postharvest apple pathogens: assessing risk factors

Wang, T. W.; Wilson, A. G.; Peck, G. M.; Gibney, P. A.; Hodge, K. T.

10.1101/2023.01.16.523797 — microbiology — Posted on 2023-01-17

2173 Antibody-drug conjugates to treat bacterial biofilms

Tvilum, A.; Illemann Johansen, M.; Glud, L.; Ivarsen, D. M.; Khamas, A. B.; Carmali, S.; Satish Mhatre, S.; Sogaard, A. B.; Faddy, E.; de Vor, L.; Rooijakkers, S.; Ostergaard, L.; Pedersen, N. J.; Meyer, R. L.; Zelikin, A. N.

10.1101/2023.01.16.524127 — microbiology — Posted on 2023-01-17

2174 Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

Ma, Y.; Li, P.; Hu, Y.; Qiu, T.; Wang, L.; Lu, H.; Lv, K.; Xu, M.; Zhuang, J.; Liu, X.; He, S.; He, B.; Liu, S.; Liu, L.; Wang, Y.; Yue, X.; Zhai, Y.; Luo, W.; Mai, H.; Zhao, W.; Chen, J.; Chen, S.; Xiong, X.; Shi, M.; Pan, J.-A.; Chen, Y.-Q.

10.1101/2023.01.15.524170 — microbiology — Posted on 2023-01-17

2175 EEF2-inactivating toxins engage the NLRP1 inflammasome and promote epithelial barrier disruption upon Pseudomonas infection

Pinilla, M.; Mazars, R.; Verge, R.; Gorse, L.; Santoni, K.; Robinson, K. S.; Toh, G. A.; Prouvensier, L.; Leonicaza, S. A.; Hessel, A.; pericat, d.; Murris, M.; Henras, A.; Buyck, J. M.; Cougoule, C.; Ravet, E.; Zhong, F. L.; Planes, R.; Meunier, E.

10.1101/2023.01.16.524164 — immunology — Posted on 2023-01-17

2176 Combinatorial gene inactivation of aldehyde dehydrogenases mitigates aldehyde oxidation catalyzed by resting cells of E. coli RARE strains

Butler, N. D.; Anderson, S.; Dickey, R.; Nain, P.; Kunjapur, A. M.

10.1101/2023.01.16.524286 — synthetic biology — Posted on 2023-01-17

2177 Discovering dynamic plant enzyme complexes in yeast for novel alkaloid pathway identification from a medicinal plant kratom

Wu, Y.; Liu, C.; Gong, F.; Li, S.

10.1101/2023.01.16.524293 — synthetic biology — Posted on 2023-01-17

2178 Exploration of the Link Between COVID-19 and Alcoholic Hepatitis from the Perspective of Bioinformatics and Systems Biology

Huang, T.; Yu, B.; Zhou, X.; Pan, H.; Du, A.; Bai, J.; Li, X.; Jiang, N.; He, J.; Wang, Z.; Yuan, K.

10.1101/2023.01.14.524034 — bioinformatics — Posted on 2023-01-17

2179 Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition

Sun, W.; Zhao, X.; Wang, J.; Yang, X.; Cheng, Z.; Liu, S.; Wang, J.; Sheng, G.; Wang, Y.

10.1101/2023.01.17.524369 — biochemistry — Posted on 2023-01-17

2180 Dissecting the basis for differential substrate specificity of ADAR1 and ADAR2

Zambrano-Mila, M. S.; Witzenberger, M.; Uzonyi, A.; Nir, R.; Ben-Aroya, S.; Levanon, E.; Schwartz, S.

10.1101/2023.01.16.524339 — biochemistry — Posted on 2023-01-17

2181 Natural evolution of SARS-CoV-2 variants in K18-ACE2 mice gives rise to more virulent virus and variant alleles associated with treatment resistance.

Willett, J. D. S.; Gravel, A.; Dubuc, I.; Gudimard, L.; Fortin, P.; Liu, J.-L.; Galvez, J. H.; Zwaig, M.; Roy, A.-M.; Lee, S.; Chen, S.-H.; Ragoussis, I.; Flamand, L.

10.1101/2023.01.16.523994 — genetics — Posted on 2023-01-17

2182 Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

Solvay, M.; Pfander, P.; Klaessens, S.; Pilotte, L.; Stroobant, V.; Lamy, J.; Naulaerts, S.; Spillier, Q.; Frederick, R.; De Plaen, E.; Sers, C.; Opitz, C. A.; Van den Eynde, B. J.; Zhu, J.

10.1101/2023.01.16.524177 — cell biology — Posted on 2023-01-17

2183 Extraordinary Evasion of Neutralizing Antibody Response by Omicron XBB.1.5, CH.1.1 and CA.3.1 Variants

Qu, P.; Faraone, J. N.; Evans, J. P.; Zheng, Y.-M.; Carlin, C.; Anghelina, M.; Stevens, P.; Fernandez, S.; Jones, D.; Lozanski, G.; Panchal, A.; Saif, L. J.; Oltz, E. M.; Xu, K.; Gumina, R. J.; Liu, S.-L.

10.1101/2023.01.16.524244 — microbiology — Posted on 2023-01-17

2184 Quorum sensing inhibits Type III-A CRISPR-Cas system activity through repressing positive regulators SarA and ArcR in Staphylococcus aureus

Li, Y.; Li, X.; Tang, Y.; Hoyland-Kroghsbo, N. M.; Ingmer, H.; Jiao, X.; Li, Q.

10.1101/2023.01.17.524377 — microbiology — Posted on 2023-01-17

2185 Peripheral extracellular vesicle-derived miR-150-3p exacerbates acute kidney injury following acute pancreatitis by promoting ferroptosis through FTH1 signaling

Tao, C. J.; Sheng, W. G.; Sheng, Y. C.; Long, C.; Yu, G. X.; Jian, H. Z.; Xin, W. Z.; Gang, W.; Liang, J.; Sheng, T. D.

10.1101/2023.01.17.524353 — cell biology — Posted on 2023-01-17

2186 Composition of nasopharyngeal microbiota in individuals with SARS-CoV-2 infection across three COVID-19 waves in India

Bose, T.; Wasimuddin, ; Acharya, V.; Pinna, N. K.; Kaur, H.; Ranjan, M.; Jandhyala, S.; Nagabandi, T.; Varma, B.; Tallapaka, K. B.; Sowpati, D. T.; Haque, M. M.; Dutta, A.; Siva, A. B.; Mande, S. S.

10.1101/2023.01.02.522449 — microbiology — Posted on 2023-01-17

2187 Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection

Baldeon Vaca, G.; Meyer, M.; Cadete, A.; Hsiao, C. J.; Golding, A.; Jeon, A.; Jacquinet, E.; Azcue, E.; Guan, C. M.; Sanchez-Felix, X.; Pietzsch, C. A.; Mire, C. E.; Hyde, M. A.; Comeaux, M. E.; Williams, J. M.; Sung, J. C.; Carfi, A.; Edwards, D. K.; Bukreyev, A.; Bahl, K.

10.1101/2023.01.11.523616 — immunology — Posted on 2023-01-17

2188 SARS-CoV-2 Protein Nsp2 Stimulates Translation Under Normal and Hypoxic Conditions

Korneeva, N.; Khalil, M. I.; Ghosh, i.; Fan, R.; Arnold, T.; De Benedetti, A.

10.1101/2022.09.13.507829 — physiology — Posted on 2023-01-17

2189 Establishment of Wnt ligand-receptor organization and cell polarity in the C. elegans embryo

Recouvreux, P.; Pai, P.; Torro, R.; Ludanyi, M.; Melenec, P.; Boughzala, M.; Bertrand, V.; Lenne, P.-F.

10.1101/2023.01.17.524363 — developmental biology — Posted on 2023-01-17

2190 Apoptosis recognition receptors regulate skin tissue repair in mice

Justynski, O.; Bridges, K.; Krause, W.; Forni, M. F.; Phan, Q.; Sandoval-Schaefer, T.; Driskell, R.; Miller-Jensen, K.; Horsley, V.

10.1101/2023.01.17.523241 — cell biology — Posted on 2023-01-17

2191 Physicochemical properties of the vacuolar membrane and cellular factors determine formation of vacuolar invaginations

Kimura, Y.; Tsuji, T.; Shimizu, Y.; Watanabe, Y.; Kimura, M.; Fujimoto, T.; Higuchi, M.

10.1101/2023.01.17.524399 — cell biology — Posted on 2023-01-17

2192 Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double strand break repair in the G1 cell cycle phase.

Dullovi, A.; Ozgencil, M.; Tse, W. Y.; Rajvee, V.; Cutillas, P.; Martin, S. A.; Licenikova Horejsi, Z.

10.1101/2023.01.17.524354 — cell biology — Posted on 2023-01-17

2193 RepairSwitch: simultaneous functional assessment of homologous recombination and end joining DNA repair pathways in living cells

Steinberg, R. C.; Liu, J.; Vaghasia, A. M.; Giovinazzo, H.; Pham, M.-T. N.; Tselenchuk, D.; Chikarmane, R.; Haffner, M. C.; Nelson, W. G.; Yegnasubramanian, S.

10.1101/2023.01.17.524235 — cell biology — Posted on 2023-01-17

2194 Human tissues exhibit diverse composition of translation machinery

Anisimova, A. S.; Kolyupanova, N. M.; Makarova, N. E.; Egorov, A. A.; Kulakovskiy, I. V.; Dmitriev, S. E.

10.1101/2023.01.16.524297 — molecular biology — Posted on 2023-01-17

2195 T492I mutation alters SARS-CoV-2 properties via modulating viral non-structural proteins

Lin, X.; Sha, Z.; Trimpert, J.; Kunec, D.; Jiang, C.; Xiong, Y.; Xu, B.; Zhu, Z.; Xue, W.; Wu, H.

10.1101/2023.01.15.524090 — microbiology — Posted on 2023-01-17

2196 Maintained imbalance of triglycerides, apolipoproteins, energy metabolites and cytokines in long-term COVID-19 syndrome (LTCS) patients

Berezhnoy, G.; Bissinger, R.; Liu, A.; Cannet, C.; Schaefer, H.; Kienzele, K.; Bitzer, M.; Haeberle, H.; Goepel, S.; Trautwein, C.; Singh, Y.

10.1101/2023.01.13.523998 — immunology — Posted on 2023-01-17

2197 Redistribution and activation of CD16brightCD56dim NK cell subset to fight against Omicron subvariant BA.2 after COVID-19 vaccination

Liu, Y.; Peng, H.; Xiang, T.; Xu, F.; Jiang, Y.; Zhong, L.; Peng, Y.; Le, A.; Zhang, W.

10.1101/2023.01.13.524025 — immunology — Posted on 2023-01-17

2198 SARS-CoV-2 Envelope protein triggers depression and dysosmia via TLR2 mediated neuroinflammation

Su, W.; Ju, J.; Gu, M.-h.; Wang, X.; Liu, S.; Yu, J.; Mu, D.

10.1101/2023.01.15.524078 — neuroscience — Posted on 2023-01-17

2199 The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

10.1101/2023.01.16.524211 — cell biology — Posted on 2023-01-17

2200 Enhanced transmissibility, infectivity and immune resistance of the SARS-CoV-2 Omicron XBB.1.5 variant

Uriu, K.; Ito, J.; Zahradnik, J.; Fujita, S.; Kosugi, Y.; Schreiber, G.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Sato, K.

10.1101/2023.01.16.524178 — microbiology — Posted on 2023-01-17

2201 Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants

Addetia, A.; Piccoli, L.; Case, J. B.; Park, Y.-J.; Beltramello, M.; Guarino, B.; Dang, H.; Pinto, D.; Scheaffer, S.; Sprouse, K.; Bassi, J.; Silacci-Fregni, C.; Muoio, F.; Dini, M.; Vincenzetti, L.; Acosta, R.; Johnson, D.; Subramanian, S.; Saliba, C.; Giurdanella, M.; Lombardo, G.; Leoni, G.; Culap, K.; McAlister, C.; Rajesh, A.; Dellota, E.; Cameroni, E.; Whitener, B.; Giannini, O.; Ceschi, A.; Ferrari, P.; Franzetti-Pellanda, A.; Biggiogero, M.; Garzoni, C.; Zappi, S.; Bernasconi, L.; Kim, M. J.; Schnell, G.; Czudnochowski, N.; Franko, N.; Logue, J. K.; Yoshiyama, C.; Stewart, C.; Chu, H.;

10.1101/2023.01.17.523798 — immunology — Posted on 2023-01-17

2202 Sex-dependent Differences in the Genomic Profile of Lingual Sensory Neurons in Naive and Tongue-Tumor Bearing Mice

Ibrahim, T.; Wu, P.; Wang, L.-J.; Tumanov, A.; Lai, Z.; Weldon, K.; Chen, Y.; Ruparel, S.

10.1101/2023.01.14.524011 — neuroscience — Posted on 2023-01-17

2203 Using a Topic Model to Map and Analyze a Large Curriculum

Takizawa, P.

10.1101/2023.01.14.524073 — scientific communication and education — Posted on 2023-01-17

2204 Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels

Wong, D. R.; Magaki, S. D.; Vinters, H. V.; Yong, W. H.; Monuki, E. S.; Williams, C. K.; Martini, A. C.; DeCarli, C.; Khacherian, C.; Graff, J. P.; Dugger, B. N.; Keiser, M. J.

10.1101/2023.01.13.524019 — pathology — Posted on 2023-01-17

2205 Principal-stretch-based constitutive neural networks autonomously discover a subclass of Ogden models for human brain tissue

St. Pierre, S. R.; Linka, K.; Kuhl, E.

10.1101/2023.01.14.524079 — biophysics — Posted on 2023-01-17

2206 Structural insights into ligand-recognition, activation, and signaling-bias at the complement C5a receptor, C5aR1

Shukla, A. K.; Saha, S.; Maharana, J.; Yadav, M.; Sarma, P.; Singh, V.; Mohapatra, S.; Soni, C.; Saha, S.; Mishra, S.; Ganguly, M.; Chami, M.; Banerjee, R.

10.1101/2023.01.14.524051 — biophysics — Posted on 2023-01-17

2207 Benchmarking Algorithms for Gene Set Scoring of Single-cell ATAC-seq Data

Wang, X.; Lian, Q.; Dong, H.; Xu, S.; Su, Y.; Wu, X.

10.1101/2023.01.14.524081 — bioinformatics — Posted on 2023-01-17

2208 scRNAseq_KNIME workflow: A Customizable, Locally Executable, Interactive and Automated KNIME workflow for single-cell RNA seq

Kausar, S.; Asif, M.; Baudot, A.

10.1101/2023.01.14.524084 — bioinformatics — Posted on 2023-01-17

2209 Integrated ACMG approved genes and ICD codes for the translational research and precision medicine

Wable, R.; Nair, A. S.; Pappu, A.; Pierre-Louis, W.; Abdelhalim, H.; Patel, K.; Mendhe, D.; Bolla, S.; Mittal, S.; Ahmed, Z.

10.1101/2023.01.14.524076 — bioinformatics — Posted on 2023-01-17

2210 Porosity-permeability tensor relationship of closely and randomly packed fibrous biomaterials and biological tissues: Application to the brain white matter

Yuan, T.; Shen, L.; Dini, D.

10.1101/2023.01.14.524065 — bioengineering — Posted on 2023-01-17

2211 Activity-based profiling of cullin-RING ligase networks by conformation-specific probes

Henneberg, L. T.; Singh, J.; Duda, D. M.; Baek, K.; Yanishevski, D.; Murray, P. J.; Mann, M.; Sidhu, S. S.; Schulman, B. A.

10.1101/2023.01.14.524048 — biochemistry — Posted on 2023-01-17

2212 Genomic resources enable insight into the developmental transcriptome of the blastoclad fungus, Coelomomyces lativittatus, an obligate parasite of mosquitoes and microcrustaceans

Ettinger, C. L.; Ostovar, T.; Yacoub, M.; Ahrendt, S.; Hice, R. H.; Federici, B. A.; Stajich, J. E.

10.1101/2023.01.14.524055 — genomics — Posted on 2023-01-17

2213 Differentiated genomic footprints and connections inferred from 440 Hmong-Mien genomes suggest their isolation and long-distance migration

He, G.; Chen, J.; Liu, Y.; Hu, R.; Wang, P.; Duan, S.; Tang, R.; Yang, J.; Wang, Z.; Xu, X.; Sun, Y.; Yun, L.; Hu, L.; Yan, J.; Nie, S.; Wei, L.; Liu, C.; Wang, M.

10.1101/2023.01.14.523079 — genetics — Posted on 2023-01-17

2214 Compensatory adaptation does not fully alleviate the costs associated with rifampicin resistance and occurs predominantly through off-target mutations

Cohen, Y.; Rozen, G. A.; Pennings, P.; Katz, S.; Hershberg, R.

10.1101/2023.01.13.524028 — evolutionary biology — Posted on 2023-01-17

2215 Functional traits of young seedlings predict trade-offs in seedling performance in three neotropical forests.

Metz, M. R.; Wright, S. J.; Zimmerman, J. K.; Hernandez, A.; Smith, S. M.; Swenson, N. G.; Umana, M. N.; Valencia, R.; Waring-Enriquez, I.; Wordell, M.; Zambrano, M.; Garwood, N. C.

10.1101/2023.01.14.523467 — ecology — Posted on 2023-01-17

2216 The fitness consequences of wildlife conservation translocations: A meta-analysis

Gross, I. P.; Wilson, A. E.; Wolak, M. E.

10.1101/2023.01.14.524021 — ecology — Posted on 2023-01-17

2217 Temporal physiological, transcriptomic and metabolomic analyses revealed molecular mechanism of Canna indica's response to Cr stress

Wei, Z.; Zhongbing, C.; Xiuqing, Y.; Luying, S.; Huan, M.; Sixi, Z.

10.1101/2023.01.14.524062 — molecular biology — Posted on 2023-01-17

2218 Microdiversity of the Vaginal Microbiome is Associated with Preterm Birth

Liao, J.; Shenhav, L.; Serrano, M.; Zhu, B.; Buck, G. A.; Korem, T.

10.1101/2023.01.13.523991 — microbiology — Posted on 2023-01-17

2219 White matter network organization predicts memory decline after epilepsy surgery

Stasenko, A.; Kaestner, E.; Arienzo, D.; Schadler, A.; Helm, J. L.; Shih, J.; Ben-Haim, S.; McDonald, C. R.

10.1101/2023.01.14.524071 — neuroscience — Posted on 2023-01-17

2220 Assessing spontaneous sensory neuron activity using in vivo calcium imaging

Ingram, S. L.; Chisholm, K. I.; Wang, F.; De Koninck, Y.; Denk, F.; Goodwin, G. L.

10.1101/2023.01.12.523728 — neuroscience — Posted on 2023-01-17

2221 Dysregulated mammalian estrus cycle rescued by timed activation of VIP neurons in the circadian pacemaker and late afternoon light exposure

Kahan, A.; Coughlin, G. M.; Borsos, M.; Brunton, B. W.; Gradinaru, V.

10.1101/2023.01.14.524075 — neuroscience — Posted on 2023-01-17

2222 Solving the Variable-Particle Size Quandary of Bone Mills. Development of an Automated Milling System to Generate Graft Particles of Definite Sizes.

Chandra, R. V.

10.1101/2023.01.13.523924 — scientific communication and education — Posted on 2023-01-17

2223 Light and temperature regulate m6A-RNA modification to regulate growth in plants

Artz, O.; Ackermann, A.; Taylor, L. J.; Koo, P.; Pedmale, U. V.

10.1101/2023.01.17.524395 — plant biology — Posted on 2023-01-17

2224 In Breast Cancer ZMIZ1 Co-Regulates E2F2 as Part of the Estrogen Receptor-Mediated Cell-Cycle Response

Zhao, W.; Rose, S. F.; Blake, R.; Godicelj, A.; Cullen, A. E.; Stenning, J.; Beevors, L.; Gehrung, M.; Kumar, S.; Kishore, K.; Sawle, A.; Eldridge, M.; Giorgi, F. M.; Bridge, K. S.; Markowetz, F.; Holding, A. N.

10.1101/789610 — cancer biology — Posted on 2023-01-17

2225 3-D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System (MANTIS)

Scholaert, M.; Houmadi, R.; Martin, J.; Serhan, N.; Tauber, M.; Braun, E.; Basso, L.; Merle, E.; Descargues, P.; Viguier, M.; Lesort, C.; Chaput, B.; Kanitakis, J.; Jullien, D.; Bulai-Livideanu, C.; Lamant, L.; Pages, E.; Gaudenzio, N.

10.1101/2023.01.13.523748 — immunology — Posted on 2023-01-17

2226 Targeted Sequencing of Pancreatic Ductal Adenocarcinoma Tissue

Thillai, K.; Benzing, C.; Quaglia, A.; Sarker, D.; Wells, C.

10.1101/2023.01.13.523431 — cancer biology — Posted on 2023-01-17

2227 GEM-DeCan: Improved tumor immune microenvironment profiling through novel gene expression and DNA methylation signatures predicts immunotherapy response

XIE, T.; Solorzano, J.; Madrid-Mencia, M.; Essabbar, A.; Pernet, J.; Kuo, M.-S.; Hucteau, A.; Coullomb, A.; Verstraete, N.; Oliver, D.; Cruzalegui, F.; Pancaldi, V.

10.1101/2021.04.09.439207 — bioinformatics — Posted on 2023-01-17

2228 PML mutants resistant to arsenic induced degradation fail to generate the appropriate SUMO and ubiquitin signals required for RNF4 and p97 recruitment

Hay, R. T.; Jaffray, E. G.; Tatham, M. H.; Ball, G.; Rojas-Fernandez, A.; Ibrahim, A. F.

10.1101/2023.01.15.524136 — cell biology — Posted on 2023-01-17

2229 Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression

Dar, M. S.; Mensah, I. K.; He, M.; McGovern, S.; Hall, M. C.; Whitlock, H. C.; Bippus, N. E.; Ceminsky, M.; GOWHER, H.

10.1101/2022.08.08.503222 — molecular biology — Posted on 2023-01-17

2230 Receptive field sizes and neuronal encoding bandwidth are constrained by axonal conduction delays.

Hladnik, T.; Grewe, J.

10.1101/2023.01.15.524163 — neuroscience — Posted on 2023-01-17

2231 Estradiol regulates voltage-gated potassium currents in corticotropin-releasing hormone neurons

Power, E. M.; Ganeshan, D.; Iremonger, K. J.

10.1101/2023.01.16.524323 — neuroscience — Posted on 2023-01-17

2232 Loss or Gain of Function? Neuronal Firing Effects of Ion Channel Mutations Depend on Cell Type

Koch, N. A.; Sonnenberg, L.; Hedrich, U. B. S.; Lauxmann, S.; Benda, J.

10.1101/2023.01.16.524256 — neuroscience — Posted on 2023-01-17

2233 Impaired polyamine metabolism causes behavioral and neuroanatomical defects in a novel mouse model of Snyder-Robinson Syndrome

Kemaladewi, D. U.

10.1101/2023.01.15.524155 — neuroscience — Posted on 2023-01-17

2234 Assessment of AlphaFold structures and optimization methods for virtual screening

Peng, Y.; Wu, X.; Lin, L.; Deng, Z.; Zhao, L.; Ke, H.

10.1101/2023.01.10.523376 — bioinformatics — Posted on 2023-01-16

2235 Tryptophan stress activates EGFR-RAS-signaling to MTORC1 and p38/MAPK to sustain translation and AHR-dependent autophagy

Pfander, P.; Hensen, L.; Razquin Navas, P.; Solvay, M.; Prentzell, M. T.; Sadik, A.; Heberle, A. M.; Seifert, S.; Regin, L.; Bausbacher, T.; Egger, A.-S.; Hotze, M.; Kipura, T.; Berdel, B.; Karabogdan, I.; Somarribas Patterson, L. F.; Reil, M.; Sayeeram, D.; Peters, V.; Ramos Pittol, J.; van t Land-Kuper, I.; Bording, T.; Trump, S.; van Pijkeren, A.; Zhang, Y.; Loayza-Puch, F.; Kowar, A.; Harder, S.; Waltl, L.; Gollowitzer, A.; Kataura, T.; Korolchuk, V. I.; Mohammed, S. A.; Sievers, P.; Sahm, F.; Schluter, H.; Koeberle, A.; Hopf, C.; Kwiatkowski, M.; Sers, C.; Van den Eynde, B. J.; Opitz, C.

10.1101/2023.01.16.523931 — biochemistry — Posted on 2023-01-17

2236 Accumulated metagenomic studies reveal recent migration, whole genome evolution, and taxonomic incompleteness of orthomyxoviruses

Dudas, G.; Batson, J.

10.1101/2022.08.31.505987 — evolutionary biology — Posted on 2023-01-16

2237 Arp2/3 Complex Activity Enables Nuclear YAP for Naive Pluripotency of Human Embryonic Stem Cells

Meyer, N. P.; Singh, T.; Kutys, M. L.; Nystul, T.; Barber, D. L.

10.1101/2023.01.16.524285 — cell biology — Posted on 2023-01-16

2238 Decreasing ELK3 expression improves Bone Morphogenetic Protein Receptor 2 signaling and pulmonary vascular cell function in PAH

Ali, M. K.; Zhao, L.; Perez, V. A. d. J.; Nicolls, M. R.; Spiekerkoetter, E.

10.1101/2023.01.14.524023 — cell biology — Posted on 2023-01-16

2239 Mechanistic insights into the role of Ca2+-stimulated AMPK in the secretion of cellulases during carbon stress

Randhawa, A.; Sinha, T.; Das, M.; Ogunyewo, O. A.; Jawed, K.; Yazdani, S. S.

10.1101/2023.01.16.524192 — cell biology — Posted on 2023-01-17

2240 LDL Receptor-Related Protein 5 is a Selective Transporter for Unesterified Polyunsaturated Fatty Acids

Tang, W.; Luan, Y.; Yuan, Q.; Li, A.; Chen, S.; Menacherry, S.; Young, L.; Wu, D. D.

10.1101/2023.01.16.524146 — cell biology — Posted on 2023-01-17

2241 Neurologically healthy humans' ability to make saccades toward unseen targets

Olkoniemi, H.; Hurme, M. J.; Railo, H.

10.1101/2022.05.27.493699 — neuroscience — Posted on 2023-01-16

2242 SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo.

Vermaercke, B.; Iwata, R.; Wierda, K.; Boubakar, L.; Rodriguez, P.; Ditkowska, M.; Bonin, V. V.; Vanderhaeghen, P.

10.1101/2023.01.14.524054 — neuroscience — Posted on 2023-01-16

2243 Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and rescue by risperidone

Delgado-Sallent, C.; Gener, T.; Nebot, P.; Lopez-Cabezon, C.; Puig, M. V.

10.1101/2023.01.16.524241 — neuroscience — Posted on 2023-01-17

2244 Benchmarking single-cell hashtag oligo demultiplexing methods

Howitt, G.; Feng, Y.; Tobar, L.; Vassiliadis, D.; Hickey, P.; Dawson, M. A.; Ranganathan, S.; Shanthikumar, S.; Neeland, M.; Maksimovic, J.; Oshlack, A.

10.1101/2022.12.20.521313 — bioinformatics — Posted on 2023-01-16

2245 Biallelic Variants in MAD2L1BP (p31comet) Cause Female Infertility Characterized by Oocyte Maturation Arrest

Huang, L.; Li, W.; Dai, X.; Zhao, S.; Xu, B.; Wang, F.; Jin, R.-T.; Luo, L.; Wu, L.; Jiang, X.; Cheng, Y.; Zou, J.; Xu, C.; Tong, X.; Fan, H.-Y.; Zhao, H.; Bao, J.

10.1101/2023.01.16.524217 — developmental biology — Posted on 2023-01-16

2246 Apical expansion of calvarial osteoblasts and suture patency is dependent on graded fibronectin cues

Feng, X.; Molteni, H.; Gregory, M.; Lanza, J.; Polsani, N.; Wyetzner, R.; Hawkins, M. B.; Holmes, G.; Hopyan, S.; Harris, M.; Atit, R.

10.1101/2023.01.16.524278 — developmental biology — Posted on 2023-01-16

2247 Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

Simon, N.; Safyan, A.; Pyrowolakis, G.; Matsuda, S.

10.1101/2023.01.15.524087 — developmental biology — Posted on 2023-01-16

2248 Primed to resolve: A single cell atlas of the shoulder capsule reveals a cellular basis for resolving inflammatory fibrosis

Ng, M. T.; Borst, R.; Gacaferi, H.; Davidson, S.; Machado, C. C.; Reekie, I.; Attar, M.; Windell, D.; Kurowska-Stolarska, M.; MacDonald, L.; Alivernini, S.; Garvilles, M.; Jansen, K.; Bhalla, A.; Lee, A.; Charlesworth, J.; Chowdhury, R.; Klenerman, P.; Powell, K.; Hackstein, C.-P.; ICECAP Study group, ; Furniss, D.; Rees, J.; Gilroy, D.; Coles, M.; Carr, A. J.; Sansom, S. N.; Buckley, C. D.; Dakin, S. G.

10.1101/2023.01.16.522218 — cell biology — Posted on 2023-01-16

2249 Mechanical forces in extendable tissue matrix orient cell divisions via microtubule stabilization in Arabidopsis

Hoermayer, L.; Montesinos, J. C.; Spona, L.; Yoshida, S.; Marhava, P.; Caballero-Mancebo, S.; Benkova, E.; Heisenberg, C.-P.; Friml, J.

10.1101/2023.01.16.524206 — cell biology — Posted on 2023-01-16

2250 Phosphorylation and Lamin B receptor modulate the accumulation of PERIOD protein foci

Li, M.; Li, S.; Zhang, L.

10.1101/2023.01.16.524233 — cell biology — Posted on 2023-01-16

2251 Size-Dependent Expression of the Fission Yeast Cdc13 Cyclin is Conferred by Translational Regulation

Bashir, S.; Sun, X.-M.; Zhao, Y.; Martinez-Illescas, N. G.; Gallego-Lopez, I.; Guerrero Negron, L.; Keifenheim, D.; Karadimitriou, T.; Tran, T.; Pickering, M.; Marguerat, S.; Rhind, N.

10.1101/2023.01.16.524304 — cell biology — Posted on 2023-01-16

2252 Age-dependent structural and morphological changes of the stem cell niche disrupt spatiotemporal regulation of stem cells and drive tissue disintegration

Urman, M. A.; John, N. S.; Lee, C.

10.1101/2023.01.15.524122 — cell biology — Posted on 2023-01-16

2253 Damage-induced senescent immune cells regulate regeneration of the zebrafish retina

Konar, G. J.; Flickinger, Z. R.; Sharma, S. P.; Vallone, K. T.; Lyon, C. E.; Doshier, C. C.; Lyon, W. D.; Patton, J. G.

10.1101/2023.01.16.524296 — cell biology — Posted on 2023-01-16

2254 Water stabilizes an alternate turn conformation in horse heart myoglobin

Marx, A.; Bronstein, A. M.

10.1101/2023.01.15.524139 — cell biology — Posted on 2023-01-16

2255 Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis

Lang, N. J.; Gote-Schniering, J.; Porras-Gonzalez, D.; Yang, L.; De Sadeleer, L. J.; Jentzsch, R. C.; Shitov, V.; Zhou, S.; Ansari, M.; Agami, A.; Mayr, C. H.; Hooshiar Kashani, B.; Chen, Y.; Heumos, L.; Pestoni, J. C.; Geeraerts, E.; Anquetil, V.; Saniere, L.; Woegrath, M.; Gerckens, M.; Hatz, R.; Kneidinger, N.; Behr, J.; Wuyts, W. A.; Stoleriu, M.-G.; Luecken, M. D.; Theis, F. J.; Burgstaller, G.; Schiller, H. B.

10.1101/2023.01.16.524219 — cell biology — Posted on 2023-01-16

2256 Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat

Zhao, W.; Johnston, K. G.; Ren, H.; Xu, X.; Nie, Q.

10.1101/2023.01.12.523826 — bioinformatics — Posted on 2023-01-16

2257 Decision Tree Ensembles Utilizing Multivariate Splits Are Effective at Investigating Beta-Diversity in Medically Relevant 16S Amplicon Sequencing Data

Rudar, J.; Golding, G. B.; Kremer, S. C.; Hajibabaei, M.

10.1101/2022.03.31.486647 — bioinformatics — Posted on 2023-01-16

2258 Hotspot of de novo telomere addition stabilizes linear amplicons in yeast grown in sulfate-limiting conditions

Hoerr, R. E.; Eng, A.; Payen, C.; DiRienzi, S. C.; Raghuraman, M. K.; Dunham, M. J.; Brewer, B. J.; Friedman, K. L.

10.1101/2022.06.12.495855 — genetics — Posted on 2023-01-16

2259 Alternative stable states in soil microbiomes of agroecosystems

Fujita, H.; Yoshida, S.; Suzuki, K.; Toju, H.

10.1101/2022.08.23.505048 — microbiology — Posted on 2023-01-16

2260 Abstraction of reward context facilitates relative reward coding in neural populations of the anterior cingulate cortex

Chien, J.; Wallis, J. D.; Rich, E. L.

10.1101/2022.12.10.519901 — neuroscience — Posted on 2023-01-16

2261 Ketamines rapid antidepressant effects are mediated by Ca2+ - permeable AMPA receptors in the hippocampus

Zaytseva, A.; Bouckova, E.; Wiles, M. J.; Wustrau, M. H.; Schmidt, I. G.; Mendez-Vazquez, H.; Khatri, L.; Kim, S.

10.1101/2022.12.05.519102 — neuroscience — Posted on 2023-01-16

2262 OptoCRISPRi-HD: engineering a green-light activated CRISPRi system with high dynamic range

Chen, K.-N.; Ma, B.-G.

10.1101/2022.12.31.522379 — synthetic biology — Posted on 2023-01-16

2263 Exploring the potential of using simulation games for engaging with sheep farmers about lameness recognition

Jones, M. L.; Barnish, M.; Hughes, R.; Murray, A.; Mansour, O.; Loni, T.; Vickery, H.; Evans, M. L.; Green, L.; Verdezoto, N.

10.1101/2022.10.26.513828 — scientific communication and education — Posted on 2023-01-16

2264 Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor

Noddings, C. M.; Johnson, J. L.; Agard, D. A.

10.1101/2023.01.10.523504 — biochemistry — Posted on 2023-01-16

2265 Seabird morphology determines operational wind speeds, tolerable maxima and responses to extremes

Nourani, E.; Safi, K.; de Grissac, S.; Anderson, D. J.; Cole, N. C.; Fell, A.; Gremillet, D.; Lempidakis, E.; Lerma, M.; McKee, J. L.; Pichegru, L.; Provost, P.; Rattenborg, N. C.; Ryan, P. G.; Santos, C. D.; Schoombie, S.; Tatayah, V.; Weimerskirch, H.; Wikelski, M.; Shepard, E.

10.1101/2022.05.02.490292 — animal behavior and cognition — Posted on 2023-01-16

2266 Near-chromosome level genome assembly of devil firefish, Pterois miles

Kitsoulis, C. V.; Papadogiannis, V.; Kristoffersen, J. B.; Kaitetzidou, E.; Sterioti, A.; Tsigenopoulos, C. S.; Manousaki, T.

10.1101/2023.01.10.523469 — genomics — Posted on 2023-01-16

2267 Loss of polarity regulators initiates gasdermin E mediated pyroptosis in human maternal fetal interface trophoblasts

Patel, K.; Nguyen, J.; Shaha, S.; Brightwell, A.; Duan, W.; Zubkowski, A.; Riddell, M.

10.1101/2022.06.30.498172 — developmental biology — Posted on 2023-01-16

2268 Sleep restores an optimal computational regime in cortical networks

Xu, Y.; Schneider, A.; Wessel, R.; Hengen, K. B.

10.1101/2022.12.07.519478 — neuroscience — Posted on 2023-01-16

2269 Efficient parameter calibration and real-time simulation of large scale spiking neural networks with GeNN and NEST

Schmitt, F. J.; Rostami, V.; Nawrot, M. P.

10.1101/2022.05.13.491646 — neuroscience — Posted on 2023-01-16

2270 Distraction and cognitive control independently impact parietal and prefrontal response to pain

Silvestrini, N.; Corradi-Dell'Acqua, C.

10.1101/2022.06.20.496774 — neuroscience — Posted on 2023-01-16

2271 Deep learning based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra.

Burkert, N.; Roy, S.; Haeusler, M.; Wuttke, D.; Mueller, S.; Wiemer, J.; Hollmann, H.; Ramirez-Franco, J.; Benkert, J.; Fauler, M.; Duda, J.; Poetschke, C.; Goaillard, J.-M.; Muenchmeyer, M.; Parlato, R.; Liss, B.

10.1101/2022.12.14.520432 — neuroscience — Posted on 2023-01-16

2272 Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain

Wu, Y.; Walker, J.; Ning, L.; Westberg, M.; Monje, M.; Kirkland, T.; Lin, M.; Su, Y.

10.1101/2022.12.30.522361 — pharmacology and toxicology — Posted on 2023-01-16

2273 Environmentally Induced Sperm RNAs Transmit Cancer Susceptibility to Offspring in a Mouse Model

da Cruz, R. S.; Dominguez, O.; Chen, E.; Gonsiewski, A. K.; Nasir, A.; Cruz, M. I.; Zou, X.; Galli, S.; Makambi, K.; McCoy, M.; Schmidt, M. O.; Jin, L.; Peran, I.; de Assis, S.

10.1101/2020.03.23.004135 — cancer biology — Posted on 2023-01-16

2274 Ion mobility mass spectrometry unveils global protein conformations in response to conditions that promote and reverse liquid-liquid phase separation

Robb, C. G.; Dao, T. P.; Ujma, J.; Castaneda, C. A.; Beveridge, R.

10.1101/2022.12.21.521395 — biophysics — Posted on 2023-01-16

2275 IMPatienT: an Integrated web application to digitize, process and explore Multimodal PATIENt daTa.

Meyer, C.; Romero, N.; Evangelista, T.; Cadot, B.; Laporte, J.; Jeannin-Girardon, A.; Collet, P.; Chennen, K.; Poch, O.

10.1101/2022.04.08.487635 — bioinformatics — Posted on 2023-01-16

2276 Integration of spatial and single-cell data across modalities with weak linkage

Chen, S.; Zhu, B.; Huang, S.; Lin, K.; Hickey, J.; Snyder, M.; Greenleaf, W.; Nolan, G. P.; Zhang, N.; Ma, Z.

10.1101/2023.01.12.523851 — bioinformatics — Posted on 2023-01-16

2277 PIsToN: Evaluating Protein Binding Interfaces with Transformer Networks

Stebliankin, V.; Shirali, A.; Baral, P.; Chapagain, P. P.; Narasimhan, G.

10.1101/2023.01.03.522623 — bioinformatics — Posted on 2023-01-16

2278 Differential retention of Pfam domains creates long-term evolutionary trends

James, J.; Nelson, P.; Masel, J.

10.1101/2022.10.27.514087 — evolutionary biology — Posted on 2023-01-16

2279 Meta-analysis of public RNA sequencing data of queens and workers in social Hymenoptera and termites

Toga, K.; Bono, H.

10.1101/2022.11.20.516280 — ecology — Posted on 2023-01-16

2280 Transient dynamics in plant-pollinator networks: Fewer but higher quality of pollinator visits determines plant invasion success

Valdovinos, F.; Dritz, S.; Marsland, R.

10.1101/2022.05.03.490461 — ecology — Posted on 2023-01-16

2281 Data Gap or Biodiversity Gap? Evaluating apparent spatial biases in community science observations of Odonata in the east-central United States.

Bullion, C. M.; Bahlai, C. A.

10.1101/2022.11.29.518107 — ecology — Posted on 2023-01-16

2282 Protein Complexes in cells by AI-assisted structural proteomics

O'Reilly, F. J.; Graziadei, A.; Forbrig, C.; Bremenkamp, R.; Charles, K.; Lenz, S.; Elfmann, C.; Fischer, L.; Stuelke, J.; Rappsilber, J.

10.1101/2022.07.26.501605 — molecular biology — Posted on 2023-01-16

2283 Transcriptomics in serum and culture medium reveal shared and differential gene regulation in pathogenic and commensal Streptococcus suis

Fredriksen, S.; Ruijten, S. D. E.; Murray, G. G. R.; Juanpere-Borras, M.; van Baarlen, P.; Boekhorst, J.; Wells, J. M.

10.1101/2022.10.16.512421 — microbiology — Posted on 2023-01-16

2284 Perception and propagation of activity through the cortical hierarchy is determined by neural variability

Rowland, J. M.; van der Plas, T. L.; Loidolt, M.; Lees, R. M.; Keeling, J.; Dehning, J.; Akam, T.; Priesemann, V.; Packer, A. M.

10.1101/2021.12.28.474343 — neuroscience — Posted on 2023-01-16

2285 Measures of Implicit and Explicit Adaptation Do Not Linearly Add

't Hart, B. M.; Taqvi, U.; Gastrock, R. Q.; Ruttle, J. E.; Modchalingam, S.; Henriques, D. Y. P.

10.1101/2022.06.07.495044 — neuroscience — Posted on 2023-01-16

2286 Cross-species comparative hippocampal transcriptomics in Alzheimer's disease

De Bastiani, M. A.; Bellaver, B.; Carello-Collar, G.; Zimmermann, M.; Kunach, P.; Lima-Filho, R. A. S.; Forner, S.; Martini, A. C.; Pascoal, T. A.; Lourenco, M. V.; Rosa-Neto, P.; Zimmer, E. R.

10.1101/2021.06.09.447404 — neuroscience — Posted on 2023-01-16

2287 Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies

De Bastiani, M. A.; Bellaver, B.; Brum, W. S.; Guerini de Souza, D.; C. L. Ferreira, P.; S. Rocha, A.; Povala, G.; Ferrari-Souza, J. P.; L. Benedet, A.; J. Ashton, N.; K. Karikari, T.; Zetterberg, H.; Blennow, K.; Rosa-Neto, P.; Pascoal, T. A.; Zimmer, E. R.; Alzheimer's Disease Neuroimaging Initiative,

10.1101/2022.02.25.481812 — neuroscience — Posted on 2023-01-16

2288 Genomic relationships among diploid and polyploid species of the genus Ludwigia L. section Jussiaea using a combination of cytogenetic, morphological, and crossing investigations

BARLOY, D.; Portillo-Lemus, L.; Krueger-Hadfield, S.; Huteau, V.; Coriton, O.

10.1101/2023.01.02.522458 — plant biology — Posted on 2023-01-16

2289 promor: a comprehensive R package for label-free proteomics data analysis and predictive modeling

Ranathunge, C.; Patel, S. S.; Pinky, L.; Correll, V. L.; Chen, S.; Semmes, O. J.; Armstrong, R. K.; Combs, C. D.; Nyalwidhe, J. O.

10.1101/2022.08.17.503867 — bioinformatics — Posted on 2023-01-16

2290 Integrative Multiomics to Dissect the Lung Transcriptional Landscape of Pulmonary Arterial Hypertension

Hong, J.; Wong, B.; Rhodes, C. J.; Kurt, Z.; Schwantes-An, T.-H.; Mickler, E. A.; Graf, S.; Eyries, M.; Lutz, K. A.; Pauciulo, M. W.; Trembath, R. C.; Montani, D.; Morrell, N. W.; Wilkins, M. R.; Nichols, W. C.; Tregouet, D.-A.; Aldred, M. A.; Desai, A. A.; Tuder, R. M.; Geraci, M. W.; Eghbali, M.; Stearman, R. S.; Yang, X.

10.1101/2023.01.12.523812 — genomics — Posted on 2023-01-16

2291 Shared patterns of population genomic variation and phenotypic response across rapid range expansions in two invasive lady beetle species

Jones, A. G.; Obrycki, J. J.; Sethuraman, A.; Weisrock, D. W.

10.1101/2023.01.13.523993 — evolutionary biology — Posted on 2023-01-16

2292 How many sirtuin genes are out there? evolution of sirtuin genes in vertebrates with a description of a new family member

Opazo, J. C.; Vandewege, M.; Hoffmann, F. G.; Zavala, K.; Melendez, C.; Luchsinger, C.; Cavieres, V.; Vargas-Chacoff, L.; Morera, F.; Burgos, P.; Tapia-Rojas, C.; Mardones, G.

10.1101/2020.07.17.209510 — evolutionary biology — Posted on 2023-01-16

2293 A standard protocol to report discrete stage-structured demographic information

Gascoigne, S. J. L.; Rolph, S.; Sankey, D.; Nidadavolu, N.; Stell Picman, A. S.; Hernandez, C. M.; Philpott, M. E. R.; Salam, A.; Bernard, C.; Fenollosa, E.; Jun Lee, Y.; McLean, J.; Hetti Achchige Perera, S.; Spacey, O. G.; Kajin, M.; Vinton, A. C.; Archer, C. R.; Burns, J. H.; Buss, D. L.; Caswell, H.; Che-Castaldo, J. P.; Childs, D. Z.; Capdevila, P.; Compagnoni, A.; Crone, E.; Ezard, T. H. G.; Hodgson, D.; Knight, T. M.; Jones, O. R.; Jongejans, E.; McDonald, J.; Tenhumberg, B.; Thomas, C. C.; Tyre, A. J.; Ramula, S.; Stott, I.; Tremblay, R. L.; Wilson, P.; Vaupel, J. W.; Salguero-Gomez, R

10.1101/2023.01.13.523871 — ecology — Posted on 2023-01-16

2294 A novel supplemental circadian feedback loop in CA1 mediates mood-related behaviors

Wang, X.-L.

10.1101/2023.01.13.524012 — neuroscience — Posted on 2023-01-16

2295 Top-down Modulation of Brain Responses in Spelling Error Recognition

Larionova, E.; Garakh, Z.; Martynova, O.

10.1101/2023.01.13.523923 — neuroscience — Posted on 2023-01-16

2296 Evidence of Lactate Shuttling in the Human Brain using Hyperpolarized 13C-MRI

Uthayakumar, B.; Soliman, H.; Chen, A. P.; Bragagnolo, N. D.; Endre, R.; Perks, W. J.; Ma, N.; Heyn, C.; Cunningham, C. H.

10.1101/2023.01.13.523957 — neuroscience — Posted on 2023-01-16

2297 Tracking movements of an endangered bird using mark-recapture based on DNA-tagging

Banuelos, M.-J.; Moran-Luis, M.; Mirol, P.; Quevedo, M.

10.1101/2023.01.12.523713 — zoology — Posted on 2023-01-16

2298 Migratory birds are able to choose the appropriate migratory direction under dim yellow monochromatic light

Romanova, N.; Utvenko, G.; Prokshina, A.; Cellarius, F.; Fedorischeva, A.; Pakhomov, A.

10.1101/2023.01.13.523666 — zoology — Posted on 2023-01-16

2299 Ornithological and molecular evidence of a reproducing Hyalomma rufipes population under continental climate in Europe

Keve, G.; Csorgo, T.; Benke, A.; Huber, A.; Morocz, A.; Nemeth, A.; Kalocsa, B.; Tamas, E. A.; Gyuracz, J.; Kiss, O.; Kovats, D.; Sandor, A. D.; Karcza, Z.; Hornok, S.

10.1101/2023.01.13.523891 — zoology — Posted on 2023-01-16

2300 Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function

Santi, A.; Kay, E. J.; Neilson, L. J.; McGarry, L.; Lilla, S.; Mullin, M.; Paul, N. R.; Fercoq, F.; Koulouras, G.; Rodriguez-Blanco, G.; Athineos, D.; Mason, S.; Hughes, M.; Kieffer, Y.; Nixon, C.; Blyth, K.; Mechta-Grigoriou, F.; Carlin, L. M.; Zanivan, S.

10.1101/2023.01.13.523951 — cancer biology — Posted on 2023-01-16

2301 Functional microRNA-Targeting Drug Discovery by Graph-Based Deep Learning

Keshavarzi Arshadi, A.; Salem, M.; Karner, H.; Garcia, K.; Arab, A.; Yuan, J. S.; Goodarzi, H.

10.1101/2023.01.13.524005 — cancer biology — Posted on 2023-01-16

2302 Region-Based Epigenetic Clock Design Improves RRBS-Based Age Prediction

Simpson, D. J.; Zhao, Q.; Olova, N.; Dabrowski, J.; Xie, X.; Crespo, E. L.; Chandra, T.

10.1101/2023.01.13.524017 — bioinformatics — Posted on 2023-01-16

2303 Transfer learning in heterogeneous drug-target interaction predictions using federated boosting

Sandor, D.; Antal, P.

10.1101/2023.01.14.524052 — bioinformatics — Posted on 2023-01-16

2304 Data-driven characterization of Preterm Birth through intramodal Diffusion MRI

Tro, R. D.; Roascio, M.; Tortora, D.; Severino, M.; Rossi, A.; Garyfallidis, E.; Arnulfo, G.; Fato, M. M.; Fadnavis, S.

10.1101/2023.01.12.523771 — bioengineering — Posted on 2023-01-16

2305 Germination timing under climate change: warmer springs favor early germination of range-wide cork oak populations

Benito Garzon, M.; Baillou, F.; Costa e Silva, F.; Faria, C.; Marchi, M.; Stiti, B.; Vendramin, G. G.; Vizcaino-Palomar, N.

10.1101/2023.01.13.523208 — ecology — Posted on 2023-01-16

2306 Bayesian areal disaggregation regression to predict wildlife distribution and relative density with low-resolution data

Murphy, K. J.; Ciuti, S.; Burkitt, T.; Morera-Pujol, V.

10.1101/2023.01.12.523783 — ecology — Posted on 2023-01-16

2307 Building modern coexistence theory from the ground up: the role of community assembly

Spaak, J. W.; Schreiber, S.

10.1101/2023.01.13.523886 — ecology — Posted on 2023-01-16

2308 Bioen-OSMOSE: A bioenergetic marine ecosystem model with physiological response to temperature and oxygen

Morell, A.; Shin, Y.-J.; Barrier, N.; Travers-Trolet, M.; Halouani, G.; Ernande, B.

10.1101/2023.01.13.523601 — ecology — Posted on 2023-01-16

2309 Testing the accuracy of species distribution models based on community science data

Velde, M.; Cooper, J. C.; Garrod, H.

10.1101/2023.01.13.523331 — ecology — Posted on 2023-01-16

2310 Reverse chemical ecology approach for sustainable palm tree protection against invasive palm weevils

Antony, B.; Montagne, N.; Comte, A.; Mfarrej, S.; Jakse, J.; Capoduro, R.; Shelke, R.; Cali, K.; AlSaleh, M. A.; Persaud, K.; Pain, A.; Jacquin-Joly, E.

10.1101/2023.01.13.523742 — ecology — Posted on 2023-01-16

2311 Between a rock and a hard place: Effects of land-use change on rock-dwelling animals of lateritic plateaus in the northern Western Ghats

Jithin, V.; Rane, M.; Watve, A.; Giri, V. B.; Naniwadekar, R.

10.1101/2023.01.12.523866 — ecology — Posted on 2023-01-16

2312 Scalable gaussian process inference of neural responses to natural images

Goldin, M. A.; Virgili, S.; Chalk, M.

10.1101/2023.01.13.523423 — neuroscience — Posted on 2023-01-16

2313 An Open-Source Platform for Head-Fixed Operant and Consummatory Behavior

Gordon-Fennell, A.; Barbakh, J. M.; Utley, M.; Singh, S.; Bazzino, P.; Gowrishankar, R.; Bruchas, M.; Roitman, M.; Stuber, G.

10.1101/2023.01.13.523828 — neuroscience — Posted on 2023-01-16

2314 Retinal ganglion cells undergo cell type-specific functional changes in a biophysically detailed model of retinal degeneration

Xu, A.; Beyeler, M.

10.1101/2023.01.13.523982 — neuroscience — Posted on 2023-01-16

2315 Manifold Learning for fMRI time-varying FC

Gonzalez-Castillo, J.; Fernandez, I. S.; Lam, K. C.; Handwerker, D. A.; Pereira, F.; Bandettini, P. A.

10.1101/2023.01.14.523992 — neuroscience — Posted on 2023-01-16

2316 Cryptochromes and UBP12/13 deubiquitinases antagonistically regulate DNA damage response in Arabidopsis

Hu, Y.; Rosado, D.; Lindback, L. N.; Micko, J.; Pedmale, U. V.

10.1101/2023.01.15.524001 — plant biology — Posted on 2023-01-16

2317 Oxycodone self-administration and reinstatement in male and female squirrel monkeys: Effects of alternative reinforcer availability

Moura, F. B.; Booth, R.; Kohut, S.

10.1101/2023.01.12.523850 — pharmacology and toxicology — Posted on 2023-01-16

2318 Integrating physics in deep learning algorithms: A force field as a PyTorch module

Orlando, G.; Serrano, L.; Schymkowitz, J.; Rousseau, F.

10.1101/2023.01.12.523724 — bioinformatics — Posted on 2023-01-16

2319 DReAmocracy: A Method to Capitalize on Prior Drug Discovery Efforts to Highlight Candidate Drugs for Repurposing

Savva, K.; Zachariou, M.; Bourdakou, M.; Dietis, N.; Spyrou, G. M.

10.1101/2023.01.12.523717 — bioinformatics — Posted on 2023-01-16

2320 Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat

Zhao, W.; Johnston, K. G.; REN, H.; Xu, X.; Nie, Q.

10.1101/2023.01.12.523826 — bioinformatics — Posted on 2023-01-16

2321 Knowledge "installed" diffusion model predicts the geometry of actin cytoskeleton from cell morphology

Li, H.; Liu, S.; Deguchi, S.; Matsunaga, D.

10.1101/2023.01.12.523863 — bioinformatics — Posted on 2023-01-16

2322 KOMPUTE: Imputing summary statistics of missing phenotypes in high-throughput model organism data

Warkentin, C.; O'Connell, M.; Lee, D.

10.1101/2023.01.12.523855 — bioinformatics — Posted on 2023-01-16

2323 BnIR: a multi-omics collaborative resource and tool platform for Brassica napus biological study

Qing-Yong, Y.; Yang, Z.; Wang, S.; Wei, L.; Huang, Y.; Liu, D.; Jia, Y.; Luo, C.; Lin, Y.; Liang, C.; Hu, Y.; Dai, C.; Guo, L.

10.1101/2023.01.12.523736 — bioinformatics — Posted on 2023-01-16

2324 MaGplotR: a software for the analysis and visualization of multiple MaGeCK screen datasets through aggregation

Matia, A.; Lorenzo, M. M.; Peng, D.

10.1101/2023.01.12.523725 — bioinformatics — Posted on 2023-01-16

2325 Computational study of Piper betle L. phytocompounds by insilico and ADMET analysis for prediction of potential xanthine oxidase inhibitory activity

Chakravarthi, V.; Karthikeyan, M.; Lakshmanan, L.; Murugesan, S.; Arivuchelvan, A.; Sukumar, K.; Arulmozhi, A.; Jagadeeswaran, A.

10.1101/2023.01.13.523909 — bioinformatics — Posted on 2023-01-16

2326 Integration of spatial and single-cell data across modalities with weak linkage

Chen, S.; Zhu, B.; Huang, S.; Lin, K.; Hickey, J.; Snyder, M.; Greenleaf, W.; Ma, Z.; Nolan, G. P.; Zhang, N.

10.1101/2023.01.12.523851 — bioinformatics — Posted on 2023-01-16

2327 RNA-to-image multi-cancer synthesis using cascaded diffusion models

Carrillo-Perez, F.; Pizurica, M.; Zheng, Y.; Shen, J.; Gevaert, O.

10.1101/2023.01.13.523899 — bioinformatics — Posted on 2023-01-16

2328 GRIP: Graph representation of immune repertoire using graph neural network and transformer

Lee, Y.; Lee, H.; Shin, K.; Kwon, S.

10.1101/2023.01.12.523879 — bioinformatics — Posted on 2023-01-16

2329 Spinal cord injury in mice amplifies anxiety: a novel light-heat conflict test exposes increased salience of anxiety over heat

Lee, S. E.; Greenough, E. K.; Fonken, L. K.; Gaudet, A. D.

10.1101/2023.01.13.523970 — animal behavior and cognition — Posted on 2023-01-16

2330 Random Forest approach for the identification of relationships between epigenetic marks and its application to robust assignment of chromatin states

Murgas, L.; Pollastri, G.; Riquelme, E.; Saez, M.; Martin, A. J. M.

10.1101/2023.01.12.523636 — genomics — Posted on 2023-01-16

2331 Gene Expression and Evolution in the Smalltooth Sawfish, Pristis Pectinata

Jarva, T. M.; Phillips, N. M.; Von Eiff, C.; Poulakis, G. R.; Naylor, G.; Feldheim, K. A.; Flynt, A. S.

10.1101/2023.01.12.523848 — evolutionary biology — Posted on 2023-01-16

2332 The evolution of parthenogen fertilization rates in switching environments: from facultative cell-fusion to oogamy

Liu, X.; Pitchford, J. W.; Constable, G. W. A.

10.1101/2023.01.13.523933 — evolutionary biology — Posted on 2023-01-16

2333 Experimentally induced drought and growing season stage modulate community-level functional traits in a temperate grassland

Fenollosa, E.; Fernandes, P.; Hector, A.; King, H.; Lawson, C.; Jackson, J.; Salguero-Gomez, R.

10.1101/2023.01.12.523738 — ecology — Posted on 2023-01-16

2334 Habitat degradation homogenizes ecological responses to typhoons across a subtropical island

Ross, S. R. P.-J.; Friedman, N. R.; Armitage, D. W.; Dudley, K. L.; Yoshida, T.; Yoshimura, M.; Economo, E. P.; Donohue, I.

10.1101/2023.01.11.523682 — ecology — Posted on 2023-01-16

2335 Divergence of alternative sugar preferences through modulation of the expression and activity of the Gal3 sensor in yeast

Fita-Torro, J.; Swamy, K. B. S.; Pascual-Ahuir, A.; Proft, M.

10.1101/2023.01.12.523712 — ecology — Posted on 2023-01-16

2336 Sustainable seed harvesting in wild plant populations

Bucharova, A.; Bossdorf, O.; Scheepens, J. F.; Salguero-Gomez, R.

10.1101/2023.01.12.523821 — ecology — Posted on 2023-01-16

2337 Calorie restriction brings no benefits to lifespan under stochastic environments

Deere, J.; Holland, P.; Aboobaker, A.; Salguero-Gomez, R.

10.1101/2023.01.12.523873 — ecology — Posted on 2023-01-16

2338 Predicting and quantifying coexistence outcomes between resident and invading species using trait and abundance data

Behm, J. E.; Ellers, J.; Jesse, W. A. M.; Tran, T. J.; Helmus, M. R.

10.1101/2023.01.12.523647 — ecology — Posted on 2023-01-16

2339 Change in Monarch Butterfly Winter Abundance Over the Past Decade: A Red List Perspective

Meehan, T. D.; Crossley, M. S.

10.1101/2023.01.12.523862 — ecology — Posted on 2023-01-16

2340 Anchoring the mean generation time in the SEIR to mitigate biases in R0 estimates due to uncertainty in the distribution of the epidemiological delays

Andrade, J.; Duggan, J.

10.1101/2023.01.13.523965 — ecology — Posted on 2023-01-16

2341 Cell Segmentation in Images Without Structural Fluorescent Labels

Zyss, D.; Ribeiro, S.; Ludlam, M. J. C.; Walter, T.; Fehri, A.

10.1101/2023.01.12.523757 — bioinformatics — Posted on 2023-01-16

2342 Death by a Thousand Cuts -- Combining Kinase Inhibitors for Selective Target Inhibition and Rational Polypharmacology

Outhwaite, I. R.; Singh, S.; Berger, B.-T.; Knapp, S.; Chodera, J. D.; Seeliger, M. A.

10.1101/2023.01.13.523972 — pharmacology and toxicology — Posted on 2023-01-16

2343 BRCA1 expression, its correlation with clinicopathological features and response to neoadjuvant chemotherapy in high grade serous ovarian cancer from an Indian centre

Patil, A.; Patil, S.; CE, A.; Rajarajan, S.; Nimbalkar, V. P.; Amirtham, U.; G, C.; MN, S.; Patil, G. V.; Nargund, A.; VR, P.; Jacob, L.; CS, P.; Prabhu, J. S.

10.1101/2023.01.11.523693 — cancer biology — Posted on 2023-01-16

2344 Proofreading Is Too Noisy For Effective Ligand Discrimination

Kirby, D.; Zilman, A.

10.1101/2023.01.13.523988 — biophysics — Posted on 2023-01-16

2345 A deep learning-based stripe self-correction method for stitched microscopic images

Wang, S.; Liu, X.; Li, Y.; Sun, X.; She, Y.; Xu, Y.; Huang, X.; Lin, R.; Kang, D.; Wang, X.; Tu, H.; Liu, W.; Huang, F.; Chen, J.

10.1101/2023.01.11.523393 — bioinformatics — Posted on 2023-01-16

2346 PhyloCoalSimulations: A simulator for network multispecies coalescent models, including a new extension for the inheritance of gene flow

Fogg, J.; Allman, E. S.; Ane, C.

10.1101/2023.01.11.523690 — evolutionary biology — Posted on 2023-01-16

2347 Unraveling the Potential Role of Tecomella undulata in Experimental NASH

Srinivas, A. N.; Suresh, D.; Suvarna, D.; Pathak, P.; Giri, S.; Pathak, S.; Satish, S.; Chidambaram, S. B.; Kumar, D. P.

10.1101/2022.08.26.505375 — physiology — Posted on 2023-01-16

2348 Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues

Bohannon, B. M.; Jowais, J. J.; Nyberg, L.; Liin, S. I.; Larsson, H. P.

10.1101/2023.01.12.523777 — physiology — Posted on 2023-01-16

2349 Genome-wide analyses of vocabulary size in infancy and toddlerhood: associations with Attention-Deficit/Hyperactivity Disorder and cognition-related traits

Verhoef, E.; Allegrini, A. G.; Jansen, P. R.; Lange, K.; Wang, C. A.; Morgan, A. T.; Ahluwalia, T. S.; Symeonides, C.; EAGLE working group, ; Eising, E.; Franken, M.-C.; Hypponen, E.; Mansell, T.; Olislagers, M.; Omerovic, E.; Rimfeld, K.; Schlag, F.; Selzam, S.; Shapland, C. Y.; Tiemeier, H.; Whitehouse, A. J. O.; Saffery, R.; Bonnelykke, K.; Reilly, S.; Pennell, C. E.; Wake, M.; Cecil, C. A. M.; Plomin, R.; Fisher, S. E.; St. Pourcain, B.

10.1101/2022.06.01.494306 — genomics — Posted on 2023-01-16

2350 Accuracy of direct genomic values and methylation profile through genotype-by-LowPass sequencing using Nanopore technology

Gonzalez-Recio, O.; Lopez-Catalina, A.; Peiro-Pastor, R.; Nieto-Valle, A.; Castro, M.; Fernandez, A.

10.1101/2023.01.15.523960 — genomics — Posted on 2023-01-16

2351 Cytoplasmic Aggregation of RPB1 Predicts Failure of Neoadjuvant Chemotherapy

Nagy-Miko, B.; Nemeth-Szatmari, O.; Farago-Meszaros, R.; Csokasi, A.; Bognar, B.; Ördög, N.; Borsos, B. N.; Majoros, H.; Ujfaludi, Z.; Olah-Nemeth, O.; Nikolenyi, A.; Dobi, A.; Koszo, R.; Santha, D.; Lazar, G.; Simonka, Z.; Paszt, A.; Ormandi, K.; Pankotai, T.; Boros, I. M.; Villanyi, Z.; Vörös, A.

10.1101/2023.01.13.523908 — cancer biology — Posted on 2023-01-16

2352 Structural insights into the interaction and multi-step activation of bacterial ExoY nucleotidyl cyclases toxins by actin-profilin

Teixeira-Nunes, M.; Retailleau, P.; Raoux-Barbot, D.; Comisso, M.; Missinou, A. A.; Velours, C.; Plancqueel, S.; Ladant, D.; Mechold, U.; Renault, L.

10.1101/2023.01.13.523968 — biophysics — Posted on 2023-01-16

2353 TissUUmaps 3: Improvements in interactive visualization, exploration, and quality assessment of large-scale spatial omics data

Pielawski, N.; Andersson, A.; Avenel, C.; Behanova, A.; Chelebian, E.; Klemm, A.; Nysjö, F.; Solorzano, L.; Wählby, C.

10.1101/2022.01.28.478131 — bioinformatics — Posted on 2023-01-16

2354 Short-term molecular consequences of chromosome mis-segregation for genome stability

Garribba, L.; De Feudis, G.; Martis, V.; Galli, M.; Dumont, M.; Eliezer, Y.; Wardenaar, R.; Ippolito, M. R.; Iyer, D. R.; Tijhuis, A. E.; Spierings, D. C.; Schubert, M.; Taglietti, S.; Soriani, C.; Gemble, S.; Basto, R.; Rhind, N.; Foijer, F.; Ben-David, U.; Fachinetti, D.; Doksani, Y.; Santaguida, S.

10.1101/2022.06.19.496702 — cell biology — Posted on 2023-01-16

2355 Assessment of Sex Bias in Housekeeping Gene Expression in Adipose Tissue Through the Massive Analysis of Transcriptomics Data

Guaita-Cespedes, M.; Grillo-Risco, R.; Hidalgo, M. R.; Fernandez-Veledo, S.; Gomez-Cabanes, B.; Anton-Bernat, G.; Gomez-Martinez, H.; Burks, D. J.; de la Iglesia-Vaya, M.; Galan, A.; Garcia-Garcia, F.

10.1101/2021.12.04.471124 — genomics — Posted on 2023-01-15

2356 Integrating proteomic data with metabolic modelling provides insight into key pathways of Bordetella pertussis biofilms

Suyama, H.; Luu, L. D. W.; Zhong, L.; Raftery, M. J.; Lan, R.

10.1101/2022.05.27.493021 — microbiology — Posted on 2023-01-16

2357 MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis

Malmierca-Merlo, P.; Sanchez-Garcia, R.; Grillo-Risco, R.; Perez-Diez, I.; Catala-Senent, J. F.; Gomez-Cabanes, B.; Anton-Bernat, G.; Gomez-Martinez, H.; de la Iglesia-Vaya, M.; Hidalgo, M. R.; Garcia-Garcia, F.

10.1101/2021.07.13.451905 — bioinformatics — Posted on 2023-01-15

2358 Drivers of asymmetrical insect invasions between three world regions

Isitt, R.; Liebhold, A. M.; Turner, R. M.; Battisti, A.; Bertelsmeier, C.; Blake, R.; Brockerhoff, E. G.; Heard, S. B.; Krokene, P.; Okland, B.; Nahrung, H.; Rassati, D.; Roques, A.; Yamanaka, T.; Pureswaran, D.

10.1101/2023.01.13.523858 — ecology — Posted on 2023-01-15

2359 A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila

Oikawa, I.; Kondo, S.; Hashimoto, K.; Yoshida, A.; Hamajima, M.; Tanimoto, H.; Furukubo-Tokunaga, K.; Honjo, K.

10.1101/2022.03.08.483420 — neuroscience — Posted on 2023-01-15

2360 A microRNA expression signature in infant t(4;11) MLL-AF4+ BCP-ALL uncovers novel therapeutic targets

Malouf, C.; Duguid, A.; Camiolo, G.; Nitsche, L.; Jakobczyk, H.; Kotecha, R.; Anderson, R.; Barrett, N.; Smith, O.; Ottersbach, K.

10.1101/2023.01.12.523775 — cancer biology — Posted on 2023-01-15

2361 Construction of Model Animals to Explore Intestinal Microbiome for Detection of Breast Cancer

Ji, X.; Li, R.; Hu, X.; Tian, Y.; Liu, L.; Zhang, C.; Xu, L.; Chen, Y.; Xie, H.; Mao, L.

10.1101/2023.01.13.523911 — cancer biology — Posted on 2023-01-15

2362 Scalable Nanopore sequencing of human genomes provides a comprehensive view of haplotype-resolved variation and methylation

Kolmogorov, M.; Billingsley, K. J.; Mastoras, M.; Meredith, M.; Monlong, J.; Lorig-Roach, R.; Asri, M.; Alvarez Jerez, P.; Malik, L.; Dewan, R.; Reed, X.; Genner, R. M.; Daida, K.; Behera, S.; Shafin, K.; Pesout, T.; Prabakaran, J.; Carnevali, P.; North American Brain Expression Consortium (NABEC), ; Yang, J.; Rhie, A.; Scholz, S. W.; Traynor, B. J.; Miga, K. H.; Jain, M.; Timp, W.; Phillippy, A. M.; Chaisson, M.; Sedlazeck, F. J.; Blauwendraat, C.; Paten, B.

10.1101/2023.01.12.523790 — bioinformatics — Posted on 2023-01-15

2363 Mass cytometry identifies characteristic immune cell subsets in bronchoalveolar lavage fluid from interstitial lung diseases

Hata, K.; Yanagihara, T.; Matsubara, K.; Kunimura, K.; Suzuki, K.; Tsubouchi, K.; Eto, D.; Ando, H.; Uehara, M.; Ikegame, S.; Baba, Y.; Fukui, Y.; Okamoto, I.

10.1101/2023.01.12.523734 — immunology — Posted on 2023-01-15

2364 Cortical topographic motifs emerge in a self-organized map of object space

Doshi, F. R.; Konkle, T.

10.1101/2022.09.06.506403 — neuroscience — Posted on 2023-01-15

2365 Simulated-to-real Benchmarking of Acquisition Methods in Metabolomics

Wandy, J.; McBride, R.; Rogers, S.; Terzis, N.; Weidt, S.; van der Hooft, J. J. J.; Bryson, K.; Daly, R.; Davies, V.

10.1101/2023.01.12.523759 — systems biology — Posted on 2023-01-15

2366 SSI: A Statistical Sensitivity Index for Chemical Reaction Networks in cancer

Biddau, G.; Caviglia, G.; Piana, M.; Sommariva, S.

10.1101/2023.01.12.523784 — systems biology — Posted on 2023-01-15

2367 Leveraging public transcriptome data with machine learning to infer pan-body age- and sex-specific molecular phenomena

Johnson, K. A.; Krishnan, A.

10.1101/2023.01.12.523796 — bioinformatics — Posted on 2023-01-15

2368 LUZP1 regulates the constriction velocity of the contractile ring during cytokinesis

Hyodo, T.; Asano-Inami, E.; Ito, S.; Sugiyama, M.; Nawa, A.; Rahman, M. L.; Hasan, M. N.; Mihara, Y.; Lam, V. Q.; Karnan, S.; Ota, A.; Tsuzuki, S.; Hamaguchi, M.; Hosokawa, Y.; Konishi, H.

10.1101/2022.07.04.498656 — cell biology — Posted on 2023-01-15

2369 Differences in the regulatory strategies of marine oligotrophs and copiotrophs reflect differences in motility

Noell, S. E.; Brennan, E.; Washburn, Q.; Davis, E. W.; Hellweger, F. L.; Giovannoni, S.

10.1101/2022.07.21.501054 — microbiology — Posted on 2023-01-15

2370 Low doses of selenium nanoparticles enhance the performance of the generalist parasitoid Anisopteromalus calandrae

Miksanek, J. R.; Adarkwah, C.; Tuda, M.

10.1101/2023.01.12.523859 — zoology — Posted on 2023-01-15

2371 Next-generation interaction proteomics for quantitative Jumbophage-bacteria interaction mapping

Fossati, A.; Mozumdar, D.; Kokontis, C. Y.; Nieweglowska, E. S.; Mendez, M.; Pelin, A.; Li, Y.; Guo, B.; Krogan, N. J.; Agard, D.; Bondy-Denomy, J.; Swaney, D. L.

10.1101/2023.01.13.523954 — systems biology — Posted on 2023-01-15

2372 Structure-function analysis of a calcium-independent metacaspase reveals a novel proteolytic pathway for lateral root emergence

Stael, S.; Sabljic, I.; Audenaert, D.; Andersson, T.; Tsiatsiani, L.; Kumpf, R. P.; Vidal-Albalat, A.; Vercammen, D.; Jacques, S.; Nguyen, L.; Njo, M.; Fernandez-Fernandez, A. D.; Beunens, T.; Timmerman, E.; Gevaert, K.; Stahlberg, J.; Bozhkov, P. V.; Linusson, A.; Beeckman, T.; Van Breusegem, F.

10.1101/2023.01.15.523950 — plant biology — Posted on 2023-01-15

2373 Perfusable biohybrid designs for bioprinted skeletal muscle tissue

Filippi, M.; Yasa, O.; Giachino, J.; Graf, R.; Balciunaite, A.; Katzschmann, R. K.

10.1101/2023.01.12.523732 — bioengineering — Posted on 2023-01-15

2374 Population Dynamics of EMT Elucidates the Timing and Distribution of Phenotypic Intra-tumoral Heterogeneity

Najafi, A.; Jolly, M. K.; George, J. T.

10.1101/2023.01.13.523978 — bioengineering — Posted on 2023-01-15

2375 Size and composition of haplotype reference panels impact the accuracy of imputation from low-pass sequencing in cattle

Lloret-Villas, A.; Pausch, H.; Leonard, A. S.

10.1101/2023.01.13.523894 — genomics — Posted on 2023-01-15

2376 Predicting the functional effect of compound heterozygous genotypes from large scale variant effect maps

Xie, M. J.; Sirr, A.; Lo, R. S.; Cromie, G. A.; Tang, M.; Ashmead, J.; Owens, K.; Kutz, J. N.; McLaughlin, R. N.; Dudley, A.

10.1101/2023.01.11.523651 — genetics — Posted on 2023-01-15

2377 Control of enhancer activation in the type I interferon response by the histone demethylase Kdm4d/JMJD2d

Chandwani, R.; Fang, T. C.; Dewell, S.; Tarakhovsky, A.

10.1101/2023.01.14.524033 — immunology — Posted on 2023-01-15

2378 NF-κB-Inducing Kinase (NIK) Governs the Mitochondrial Respiratory Capacity, Differentiation, and Inflammatory Status of Innate Immune Cells

Keeney, J. N.; Winters, A. D.; Sitcheran, R.; West, A. P.

10.1101/2022.08.06.503047 — immunology — Posted on 2023-01-15

2379 Rescue of neurogenesis and age-associated cognitive decline in SAMP8 mouse: role of transforming growth factor alpha

Gomez-Oliva, R.; Martinez-Ortega, S.; Atienza-Navarro, I.; Bernal, C.; Dominguez-Garcia, S.; Geribaldi-Doldan, N.; Verastegui, C.; Ezzanad, A.; Hernandez-Galan, R.; Nunez-Abades, P.; Garcia-Alloza, M.; Castro, C.

10.1101/2023.01.14.524036 — neuroscience — Posted on 2023-01-15

2380 Improving gene regulatory network inference and assessment: The importance of using network structure

Escorcia-Rodriguez, J. M.; Gaytan-Nunez, E.; Hernandez-Benitez, E. M.; Zorro-Aranda, A.; Tello-Palencia, M. A.; Freyre-Gonzalez, J. A.

10.1101/2023.01.12.523840 — systems biology — Posted on 2023-01-15

2381 Context-aware knowledge selection and reliable model recommendation with ACCORDION

Ahmed, Y.; Telmer, C.; Zhou, G.; Miskov-Zivanov, N.

10.1101/2022.01.22.477231 — systems biology — Posted on 2023-01-15

2382 Analysis and modeling of cancer drug responses using cell cycle phase-specific rate effects

Gross, S. M.; Mohammadi, F.; Sanchez-Aguila, C.; Zhan, P. J.; Liby, T. A.; Dane, M. A.; Meyer, A. S.; Heiser, L. M.

10.1101/2020.07.24.219907 — cancer biology — Posted on 2023-01-15

2383 DNA Methylation Signatures in Breast Cancer: A Systematic Review and Meta-Analysis

Trasierras-Fresco, A. M.; Andreu, Z.; Hidalgo, M. R.; Gomez-Cabanes, B.; Anton-Bernat, G.; Malmierca-Merlo, P.; Romera-Giner, S.; Crespo, D.; Gomez-Martinez, H.; Serna-Blasco, R.; Romero, A.; Lopez-Guerrero, J. A.; de la Iglesia Vaya, M.; Garcia-Garcia, F.

10.1101/2022.10.15.512358 — cancer biology — Posted on 2023-01-15

2384 Effect of Adult-Born Immature Granule Cells on Pattern Separation in The Hippocampal Dentate Gyrus

Kim, S.-Y.; Lim, W.

10.1101/2023.01.12.523852 — biophysics — Posted on 2023-01-15

2385 MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis

Malmierca-Merlo, P.; Sanchez-Garcia, R.; Grillo-Risco, R.; Perez-Diez, I.; Catala-Senent, J. F.; Gomez-Cabanes, B.; Anton-Bernat, G.; de la Iglesia-Vaya, M.; Hidalgo, M. R.; Garcia-Garcia, F.

10.1101/2021.07.13.451905 — bioinformatics — Posted on 2023-01-15

2386 Modeling Flow in an In Vitro Anatomical Cerebrovascular Model with Experimental Validation

Bhardwaj, S.; Craven, B. A.; Sever, J. E.; Costanzo, F.; Simon, S. D.; Manning, K. B.

10.1101/2023.01.13.523948 — bioengineering — Posted on 2023-01-15

2387 Photocurrent production from cherries in a bio-electrochemical cell.

Shlosberg, Y.

10.1101/2023.01.13.524022 — bioengineering — Posted on 2023-01-15

2388 A new label-free optical imaging method for the lymphatic system enhanced by deep learning

Li, Z.; Huang, S.; He, Y.; van Wijnbergen, J. W.; Zhang, Y.; Cottrell, R. D.; Smith, S. G.; Hammond, P. T.; Chen, D. Z.; Padera, T. P.; Belcher, A. M.

10.1101/2023.01.13.523938 — bioengineering — Posted on 2023-01-15

2389 Evaluation of the morphological and biological functions of vascularized microphysiological systems with supervised machine learning

Tronolone, J. J.; Mathur, T.; Chaftari, C.; Jain, A.

10.1101/2023.01.12.523755 — bioengineering — Posted on 2023-01-15

2390 Long term anthropic management and associated loss of plant diversity deeply impact virome richness and composition of Poaceae communities

Maclot, F.; Debue, V.; Malmstrom, C. M.; Filloux, D.; Roumagnac, P.; Eck, M.; Tamisier, L.; Blouin, A. G.; Candresse, T.; Massart, S.

10.1101/2023.01.12.523554 — genomics — Posted on 2023-01-15

2391 Fathers' preconception smoking and offspring DNA methylation: A two generation study

Kitaba, N. T.; Knudsen, G. T. M.; Johannessen, A.; Rezwan, F. I.; Malinovschi, A.; Oudin, A.; Benediktsdottir, B.; Martino, D.; Callejas Gonzalez, F. J.; Gomez, L. P.; Holm, M.; Jogi, N. O.; Dharmage, S. C.; Watkins, S. H.; Suderman, M.; Skulstad, S. M.; Gomez-Real, F.; Schlunssen, V.; Svanes, C.; Holloway, J. W.

10.1101/2023.01.13.523912 — genomics — Posted on 2023-01-15

2392 Assessment of Sex Bias in Housekeeping Gene Expression in Adipose Tissue Through the Massive Analysis of Transcriptomics Data

Guaita-Cespedes, M.; Grillo-Risco, R.; Hidalgo, M. R.; Fernandez-Veledo, S.; Gomez-Cabanes, B.; Anton-Bernat, G.; Burks, D. J.; de la Iglesia-Vaya, M.; Galan, A.; Garcia-Garcia, F.

10.1101/2021.12.04.471124 — genomics — Posted on 2023-01-15

2393 Learning functional conservation between pig and human to decipher evolutionary mechanisms underlying gene expression and complex trait

Li, J.; Zhao, T.; Guan, D.; Pan, Z.; Bai, Z.; Teng, J.; Zhang, Z.; Zheng, Z.; Zeng, J.; Zhou, H.; Fang, L.; Cheng, H.

10.1101/2023.01.13.523857 — genetics — Posted on 2023-01-15

2394 Pollen-feeding delays reproductive senescence and maintains toxicity of Heliconius butterflies

Pinheiro de Castro, E. C.; McPherson, J.; Julian, G.; Mattila, A.; Bak, S.; Montgomery, S.; Jiggins, C.

10.1101/2023.01.13.523799 — evolutionary biology — Posted on 2023-01-15

2395 Global biogeography of the smallest plankton across ocean depths

Junger, P. C.; Sarmento, H.; Giner, C. R.; Mestre, M.; Sebastian, M.; Moran, X. A. G.; Aristegui, J.; Agusti, S.; Duarte, C. M.; Acinas, S. G.; Massana, R.; Gasol, J. M.; Logares, R.

10.1101/2023.01.13.523743 — ecology — Posted on 2023-01-15

2396 Drivers of plant diversity, community composition, functional traits and soil processes along an alpine gradient in the central Chilean Andes

Schroeder, L.; Robles, V.; Jara-Arancio, P.; Lapadat, C.; Hobbie, S. E.; Arroyo-Kalin, M. T.; Cavender-Bares, J.

10.1101/2023.01.13.523936 — ecology — Posted on 2023-01-15

2397 Seedling performance in a dioecious tree species is similar near female and male conspecific adults despite differences in colonization by arbuscular mycorrhizal fungi

Eck, J. L.; Delavaux, C. S.; Wilson, D. M.; Queenborough, S. A.; Comita, L. S.

10.1101/2023.01.13.523901 — ecology — Posted on 2023-01-15

2398 Growth increases but regeneration declines in response to warming and drying at Arctic treeline in white spruce (Picea glauca)

Jensen, J.; Boelman, N.; Eitel, J.; Vierling, L.; Maguire, A.; Oelkers, R.; Silva, C.; Andreu-Hayles, L.; D'Arrigo, R.; Griffin, K. L.

10.1101/2023.01.12.523811 — ecology — Posted on 2023-01-15

2399 Global patterns of plant form and function are strongly determined by evolutionary relationships

Capdevila, P.; Walker, T.; Schrodt, F.; Rodriguez Caro, R.; Salguero-Gomez, R.

10.1101/2023.01.13.523963 — ecology — Posted on 2023-01-15

2400 Keratinocyte-derived paracrine factors regulate stress response of melanocytes to UVB

Jeayeng, S.; Saelim, M.; Muanjumpon, P.; Buraphat, P.; Kanchanapiboon, P.; Sampattavanich, S.; Panich, U.

10.1101/2023.01.13.523939 — pharmacology and toxicology — Posted on 2023-01-15

2401 Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions

Carpenter, E. S.; Elhossiny, A. M.; Kadiyala, P.; Li, J.; McGue, J.; Griffith, B.; Zhang, Y.; Edwards, J.; Nelson, S.; Lima, F.; Donahue, K. L.; Du, W.; Bischoff, A. C.; Alomari, D.; Watkoske, H.; Mattea, M.; The, S.; Espinoza, C.; Barrett, M.; Sonnenday, C. J.; Olden, N.; Peterson, N.; Gunchick, V.; Sahai, V.; Rao, A.; Bednar, F.; Shi, J.; Frankel, T. L.; Pasca Di Magliano, M.

10.1101/2023.01.13.523300 — cancer biology — Posted on 2023-01-15

2402 GeneMark-ETP: Automatic Gene Finding in Eukaryotic Genomes in Consistence with Extrinsic Data

Bruna, T.; Lomsadze, A.; Borodovsky, M.

10.1101/2023.01.13.524024 — bioinformatics — Posted on 2023-01-15

2403 SunTag-PE: a modular prime editing system enables versatile and efficient genome editing

Hu, Z.; Tian, R.; Liu, J.; Chen, Y.; Huang, Z.; Li, L.; Wang, Y.; Zhong, C.; Zhao, T.

10.1101/2023.01.13.524016 — bioengineering — Posted on 2023-01-15

2404 A highly divergent mitochondrial genome in extant Cape buffalo from Addo Elephant National Park, South Africa

de Jager, D.; Moller, M.; Hoal, E. G.; van Helden, P.; Glanzmann, B.; Harper, C. K.; Bloomer, P.

10.1101/2023.01.14.524049 — genetics — Posted on 2023-01-15

2405 Oviposition behaviour is not affected by ultraviolet light in a butterfly with sexually-dimorphic expression of a UV-sensitive opsin

Borrero Malo, J.; Wright, D. S.; Bacquet, C. N.; Merrill, R. M.

10.1101/2023.01.11.523610 — evolutionary biology — Posted on 2023-01-15

2406 Description of Protosticta armageddonensis sp. nov. (Odonata: Zygoptera: Platystictidae) from the Western Ghats of India

Payra, A.; Chandran, R.; Deshpande, A.; Koparde, P.

10.1101/2023.01.11.523583 — zoology — Posted on 2023-01-15

2407 A Novel Algorithm to Calculate Elementary Modes: Analysis of Campylobacter jejuni Metabolism

Said, Y.; Singh, D.; Sebu, C.; Poolman, M.

10.1101/2023.01.11.521685 — systems biology — Posted on 2023-01-15

2408 Structural Interaction Fingerprints and Machine Learning for predicting and explaining binding of small molecule ligands to RNA

Szulc, N. A.; Mackiewicz, Z.; Bujnicki, J. M.; Stefaniak, F.

10.1101/2023.01.11.523582 — bioinformatics — Posted on 2023-01-15

2409 The Nucleotide Transformer: Building and Evaluating Robust Foundation Models for Human Genomics

Dalla-Torre, H.; Gonzalez, L.; Mendoza Revilla, J.; Lopez Carranza, N.; Henryk Grywaczewski, A.; Oteri, F.; Dallago, C.; Trop, E.; Sirelkhatim, H.; Richard, G.; Skwark, M.; Beguir, K.; Lopez, M.; Pierrot, T.

10.1101/2023.01.11.523679 — genomics — Posted on 2023-01-15

2410 Canary in the Forest? Tree mortality and canopy dieback of western redcedar linked to drier and warmer summer conditions

Andrus, R. A.; Peach, L. R.; Cinquini, A.; Mills, B.; Yusi, J.; Buhl, C. J.; Fischer, M.; Goodrich, B. A.; Holz, A.; Hulbert, J. M.; Meddens, A. J. H.; Moffett, K.; Ramirez, A.; Adams, H. D.

10.1101/2023.01.11.522134 — ecology — Posted on 2023-01-15

2411 Newer Surveillance Data Extends our Understanding of the Niche of Rickettsia montanensis (Rickettsiales: Rickettsiaceae) Infection of the American Dog Tick (Acari: Ixodidae) in the United States.

Lippi, C. A.; Gaff, H. D.; Nadolny, R. M.; Ryan, S. J.

10.1101/2023.01.11.523628 — ecology — Posted on 2023-01-15

2412 A temporal atlas and response to nitrate availability of 3D root system architecture in diverse pennycress (Thlaspi arvense L.) accessions

Griffiths, M.; Liu, A. E.; Gunn, S. L.; Mutan, N. M.; Morales, E. Y.; Topp, C. N.

10.1101/2023.01.14.524046 — plant biology — Posted on 2023-01-15

2413 Variational graph encoders: a surprisingly effective generalist algorithm for holistic computer-aided drug design

Lam, H. Y. I.; Pincket, R.; Han, H.; Ong, X. E.; Wang, Z.; Li, W.; Hinks, J.; Zheng, L.; Wei, Y.; Mu, Y.

10.1101/2023.01.11.523575 — bioinformatics — Posted on 2023-01-15

2414 Sensitive inference of alignment-safe intervalsfrom biodiverse protein sequence clusters usingEMERALD

Grigorjew, A.; Gynter, A.; Dias, F.; Buchfink, B.; Drost, H.-G.; Tomescu, A. I.

10.1101/2023.01.11.523286 — bioinformatics — Posted on 2023-01-15

2415 Magnetic Resonance Fingerprinting based Thermometry (MRFT): application to ex vivo imaging near DBS leads

Qian, E.; Poojar, P.; Fung, M.; Jin, Z.; Vaughan, J. T.; Shrivastava, D.; Gultekin, D.; Fernandes, T.; Geethanath, S.

10.1101/2023.01.11.523421 — bioengineering — Posted on 2023-01-15

2416 Immature leaves are the dominant volatile (Z)-3-hexenyl acetate sensing organs of maize

Wang, L.; Jaeggi, S.; Walthert, M.; Waterman, J. M.; Cofer, T. M.; Erb, M.

10.1101/2023.01.12.523648 — plant biology — Posted on 2023-01-15

2417 Grapevine scion gene expression is driven by rootstock and environment interaction

Harris, Z. N.; Pratt, J. E.; Kovacs, L. G.; Klein, L. L.; Kwasniewski, M. T.; Londo, J. P.; Wu, A.; Miller, A. J.

10.1101/2023.01.12.523795 — plant biology — Posted on 2023-01-15

2418 An assay to reliably achieve Tar Spot symptoms on corn in a controlled environment

Breuing, M.; Bittner, R.; Dolezal, A.; Ramcharan, A.; Bunkers, G. J.

10.1101/2023.01.12.523803 — plant biology — Posted on 2023-01-15

2419 PIF transcriptional regulators are required for rhythmic stomatal movements

Rovira, A.; Veciana, N.; Locascio, A.; Yenush, L.; Leivar, P.; Monte, E.

10.1101/2023.01.14.524044 — plant biology — Posted on 2023-01-15

2420 Hypometabolism to survive the long polar night in the diatom Fragilariopsis cylindrus

Joli, N.; Concia, L.; Mocaer, K.; Guterman, J.; Laude, J.; Guerin, S.; Sciandra, T.; Bruyant, F.; Ait-Mohamed, O.; Beguin, M.; Forget, M.-H.; Bourbousse, C.; Lacour, T.; Bailleul, B.; Tremblay, J.-E.; Campbell, D.; Lavaud, J.; Schwab, Y.; Babin, M.; Bowler, C.

10.1101/2023.01.14.524047 — ecology — Posted on 2023-01-15

2421 High Throughput Sequencing technologies complemented by growers perception highlight the impact of tomato virome in diversified vegetable farms

Temple, C.; Blouin, A. G.; Tindale, S. J.; Steyer, S.; Marechal, K.; Massart, S.

10.1101/2023.01.12.523758 — plant biology — Posted on 2023-01-15

2422 Cell segmentation for high-resolution spatial transcriptomics

Chen, H.; Li, D.; Bar-Joseph, Z.

10.1101/2023.01.11.523658 — bioinformatics — Posted on 2023-01-15

2423 A scalable, Rotating Disc Bioelectrochemical Reactor (RDBER) suitable for the cultivation of both cathodic and anodic biofilms

Hackbarth, M.; Gescher, J.; Horn, H.; Reiner, J. E.

10.1101/2022.09.12.507646 — microbiology — Posted on 2023-01-15

2424 Cytoplasmic Aggregation of RPB1 Predicts Failure of Neoadjuvant Chemotherapy

10.1101/2023.01.13.523908 — cancer biology — Posted on 2023-01-15

2425 Actin networks modulate heterogenous NF-κB dynamics in response to TNFα

Butera, F.; Sero, J. E.; Dent, L. G.; Bakal, C.

10.1101/2022.01.19.476961 — cancer biology — Posted on 2023-01-15

2426 The role of intestine in metabolic dysregulation in murine Wilson disease

Sarode, G. V.; Mazi, T. A.; Neier, K. E.; Shibata, N. M.; Jospin, G.; Harder, N. H. O.; Heffern, M.; Sharma, A. K.; More, S.; Dave, M.; Schroeder, S. M.; Wang, L.; LaSalle, J. M.; Svetlana, L.; Medici, V.

10.1101/2023.01.13.524009 — molecular biology — Posted on 2023-01-15

2427 Phosphorylation of PSD-95 at Serine 73 in dCA1 is required for extinction of contextual fear

Ziołkowska, M.; Borczyk, M.; Cały, A.; Nalberczak-Skora, M.; Nowacka, A.; Sliwinska, M. A.; Łukasiewicz, K.; Skonieczna, E.; Tomaszewski, K. F.; Wojtowicz, T.; Wlodarczyk, J.; Bernas, T.; Salamian, A.; Radwanska, K.

10.1101/2023.01.11.523603 — neuroscience — Posted on 2023-01-15

2428 Unveiling abundance-dependent metabolic phenotypes of microbial communities

Jimenez, N. E.; Acuna, V.; Cortes, M. P.; Eveillard, D.; Maass, A. E.

10.1101/2023.01.10.523517 — bioinformatics — Posted on 2023-01-15

2429 Automated quantitative trait locus analysis (AutoQTL)

Freda, P. J.; Ghosh, A.; Zhang, E.; Luo, T.; Chitre, A.; Polesskaya, O.; St. Pierre, C. L.; Gao, J.; Martin, C. D.; Chen, H.; Garcia-Martinez, A. G.; Wang, T.; Han, W.; Ishiwari, K.; Meyer, P.; Lamparelli, A.; King, C. P.; Palmer, A. A.; Li, R.; Moore, J. H.

10.1101/2023.01.12.523835 — genetics — Posted on 2023-01-15

2430 Systemic orchestration of cell size throughout the body: Influence of sex and rapamycin exposure in Drosophila melanogaster

Szlachcic, E.; Labecka, A. M.; Privalova, V.; Sikorska, A.; Czarnoleski, M.

10.1101/2023.01.11.521715 — developmental biology — Posted on 2023-01-15

2431 Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain

Ganz, J.; Luquette, L. J.; Bizzotto, S.; Bohrson, C.; Jin, H.; Miller, M. B.; Zhou, Z.; Galor, A.; Park, P. J.; Walsh, C. A.

10.1101/2023.01.14.523958 — neuroscience — Posted on 2023-01-14

2432 Bacterial lipoxygenases are associated with host-microbe interactions and may provide cross-kingdom host jumps

Kurakin, G.

10.1101/2022.06.21.497025 — bioinformatics — Posted on 2023-01-14

2433 Millisecond-scale behaviours of plankton quantified in situ and in vitro using the Event-based Vision Sensor (EVS)

Takatsuka, S.; Miyamoto, N.; Sato, H.; Morino, Y.; Kurita, Y.; Yabuki, A.; Chen, C.; Kawagucci, S.

10.1101/2023.01.11.523686 — animal behavior and cognition — Posted on 2023-01-14

2434 Home-field advantage affects the local adaptive interaction between Andropogon gerardii ecotypes and rhizobiome

Kazarina, A.; Sarkar, S.; Thapa, S.; Heeren, L.; Kamke, A.; Ward, K.; Hartung, E.; Ran, Q.; Galliart, M.; Jumpponen, A.; Johnson, L.; Lee, S. T. M.

10.1101/2023.01.04.522809 — microbiology — Posted on 2023-01-14

2435 MetaPathPredict: A machine learning-based tool for predicting metabolic modules in incomplete bacterial genomes

Geller-McGrath, D.; Konwar, K.; Edgcomb, V. P.; Pachiadaki, M.; Roddy, J.; Wheeler, T.; McDermott, J. E.

10.1101/2022.12.21.521254 — bioinformatics — Posted on 2023-01-14

2436 Cost-effective DNA methylation profiling by FML-seq

Foley, J. W.; Zhu, S. X.; West, R. B.

10.1101/2023.01.13.523849 — genomics — Posted on 2023-01-14

2437 Tissue-specific chromatin binding patterns of C. elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression.

de la Cruz Ruiz, P.; Askjaer, P.; Artal-Sanz, M.

10.1101/2023.01.13.523961 — genomics — Posted on 2023-01-14

2438 An intravenous DNA-binding priming agent protects cell-free DNA and improves the sensitivity of liquid biopsies

Tabrizi, S.; Martin-Alonso, C.; Xiong, K.; Blewett, T.; Sridhar, S.; An, Z.; Patel, S.; Rodriguez-Aponte, S. A.; Naranjo, C. A.; Wang, S.-T.; Shea, D.; Golub, T.; Bhatia, S.; Adalsteinsson, V.; Love, J. C.

10.1101/2023.01.13.523947 — genomics — Posted on 2023-01-14

2439 Near-chromosome level genome assembly of devil firefish, Pterois miles

Kitsoulis, C. V.; Papadogiannis, V.; Kristoffersen, J. B.; Kaitetzidou, E.; Sterioti, A.; Tsigenopoulos, C. S.; Manousaki, T.

10.1101/2023.01.10.523469 — genomics — Posted on 2023-01-14

2440 SUMO protease FUG1, histone reader AL3 and the PRC1 Complex are integral to repeat-expansion induced epigenetic silencing in Arabidopsis thaliana

Sureshkumar, S.; Bandaranayake, C.; Lu, J.; Dent, C. I.; Atri, C.; York, H. M.; Tamizhselvan, P.; Shamaya, N.; Folini, G.; Bhagat, P. K.; Bergey, B. G.; Singh Yadav, A.; Kumar, S.; Grummisch, O.; Saini, P.; Yadav, R. K.; Arumugam, S.; Rosonina, E.; Sadanandom, A.; Liu, H.; Balasubramanian, S.

10.1101/2023.01.13.523841 — genetics — Posted on 2023-01-14

2441 Expanding the HDAC druggable landscape beyond enzymatic activity

Olivet, J.; Choi, S. G.; Sierra, S.; O'Grady, T. M.; de la Fuente Revenga, M.; Laval, F.; Botchkarev, V. V.; Gorgulla, C.; Coote, P. W.; Blavier, J.; Geffken, E. A.; Lakhani, J.; Song, K.; Yeoh, Z. C.; Hu, B.; Varca, A. C.; Bruyr, J.; Ibrahim, S.; Jivanjee, T.; Bromley, J. D.; Nyquist, S. K.; Richardson, A.; Yue, H.; Wang, Y.; Calonghi, N.; Stephan, A.; Spirohn, K.; Vertommen, D.; Baietti, M. F.; Lemmens, I.; Seo, H.-S.; Dozmorov, M. G.; Willems, L.; Tavernier, J.; Das, K.; Leucci, E.; Hochkoeppler, A.; Sun, Z.-Y. J.; Calderwood, M. A.; Hao, T.; Shalek, A. K.; Hill, D. E.; Boeszoermenyi, A.; A

10.1101/2022.12.07.519454 — molecular biology — Posted on 2023-01-14

2442 Glycogen degrading activities of catalytic domains of α-amylase and α-amylase-pullulanase enzymes conserved in Gardnerella spp. from the vaginal microbiome

Bhandari, P.; Tingley, J. P.; Abbott, D. W.; Hill, J. E.

10.1101/2022.10.19.512974 — microbiology — Posted on 2023-01-14

2443 Tobramycin adaptation alters the antibiotic susceptibility of Pseudomonas aeruginosa quorum sensing-null mutants

Abisado-Duquea, R. G.; McKee, B. M.; Townsend, K. A.; Woods, K.; Holder, A. J.; Craddock, V. D.; Cabeen, M. T.; Chandler, J. R.

10.1101/2023.01.13.523864 — microbiology — Posted on 2023-01-14

2444 Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

Kennedy, K.; Plagemann, A.; Sommer, J.; Hofmann, M.; Henrich, W.; Barrett, J. F. R.; Surette, M. G.; Atkinson, S.; Braun, T.; Sloboda, D. M.

10.1101/2022.09.02.506244 — microbiology — Posted on 2023-01-14

2445 Activation of the Plasmodium egress effector subtilisin-like protease 1 is achieved by plasmepsin X destruction of the propiece.

Mukherjee, S.; Nasamu, A. S.; Rubiano, K.; Goldberg, D.

10.1101/2023.01.13.524002 — microbiology — Posted on 2023-01-14

2446 Enhanced protein synthesis is a defining requirement for neonatal B cell development

Akerstrand, H.; Boldrin, E.; Montano, G.; Vanhee, S.; Olsson, K.; Krausse, N.; Vergani, S.; Ciesla, M.; Bellodi, C.; Yuan, J.

10.1101/2022.11.11.515795 — immunology — Posted on 2023-01-14

2447 Insm1 regulates the development of mTECs and immune tolerance

Tao, W.; Wei, Y.; Ye, Z.; Wang, J.; Yang, W.; Yu, G.; Xiong, J.; Jia, S.

10.1101/2023.01.14.524041 — immunology — Posted on 2023-01-14

2448 Gait behavioral and neuromuscular characterization in response to increasing working memory load while walking under optic flow perturbations in young adults

LANA, V.; FRERE, J.; CABIBEL, V.; REGUEME, T.; LEFEVRE, N.; DECKER, L. M.

10.1101/2022.07.01.498421 — neuroscience — Posted on 2023-01-14

2449 Measures of Implicit and Explicit Adaptation Do Not Linearly Add

't Hart, B. M.; Taqvi, U.; Gastrock, R. Q.; Ruttle, J. E.; Modchalingam, S.; Henriques, D. Y. P.

10.1101/2022.06.07.495044 — neuroscience — Posted on 2023-01-14

2450 Area postrema neurons mediate interleukin-6 function in cancer-associated cachexia

Sun, Q.; van de Lisdonk, D.; Ferrer, M.; Gegenhuber, B.; Wu, M.; Tollkuhn, J.; Janowitz, T.; Li, B.

10.1101/2023.01.12.523716 — neuroscience — Posted on 2023-01-14

2451 Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic manner

Ju, A.; Altas, B.; Rhee, H. J.; Schwark, M.; Hassouna, I.; Sigler, A.; Kawabe, H.; Chowdhury, K.; Ehrenreich, H.; Brose, N.; Rhee, J. S.

10.1101/2022.12.19.521004 — neuroscience — Posted on 2023-01-14

2452 Habitual aerobic exercise evokes fast and persistent adaptation during split-belt walking

Brinkerhoff, S. A.; Sanchez, N.; Roper, J. A.

10.1101/2022.06.30.498334 — neuroscience — Posted on 2023-01-14

2453 High frequency soil polarization can phenotype crop roots noninvasively

Gu, H.; Cseresnyes, I.; Butnor, J.; Li, B.; Mary, B.; Sun, H.; Zhang, X.; Lu, Y.; Liu, X.

10.1101/2023.01.12.523853 — plant biology — Posted on 2023-01-14

2454 E4F1 and ZNF148 are transcriptional activators of the A57C and wildtype TERT promoter

Chua, B. H.; Ferry, L.; Domrane, C.; Zaal Anuar, N.; Wittek, A.; Jha, S.; Butter, F.; Tenen, D. G.; Defossez, P.-A.; Kappei, D.

10.1101/2023.01.13.523884 — cancer biology — Posted on 2023-01-14

2455 In vitro and in vivo evidences propound therapeutic potential of Lipocalin 2 in cervical carcinoma

Dwivedi, N.; Mazumder, T.; Veeraraghavan, G.; Siva, R.; P K, S.; Ranade, R.; Das, M.; Dhar, S. K.

10.1101/2023.01.13.523914 — cancer biology — Posted on 2023-01-14

2456 The regulatory role of the CD2AP/TKS4 interaction in EMT and its potential as abiomarker for colon cancer

Kurilla, A.; Laszlo, L.; Takacs, T.; Tilajka, A.; Lukacs, L.; Novak, J.; Pancsa, R.; Buday, L.; Vas, V.

10.1101/2023.01.13.523903 — cancer biology — Posted on 2023-01-14

2457 Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses

Ramos Zapatero, M.; Tong, A.; Sufi, J.; Vlckova, P.; Cardoso Rodriguez, F.; Nattress, C.; Qin, X.; Hochhauser, D.; Krishnaswamy, S.; Tape, C. J.

10.1101/2022.10.19.512668 — cancer biology — Posted on 2023-01-14

2458 Structural insights into the interaction and multi-step activation of bacterial ExoY nucleotidyl cyclases toxins by actin-profilin

Teixeira-Nunes, M.; Retailleau, P.; Raoux-Barbot, D.; Comisso, M.; Missinou, A. A.; Velours, C.; Plancqueel, S.; Ladant, D.; Mechold, U.; Renault, L.

10.1101/2023.01.13.523968 — biophysics — Posted on 2023-01-14

2459 Fluorescent protein lifetimes report increased local densities and phases of nuclear condensates during embryonic stem cell differentiation

Joron, K.; Viegas, J. O.; Haas-Neill, L.; Bier, S.; Drori, P.; Dvir, S.; Lim, P. S. L.; Rauscher, S.; Meshorer, E.; Lerner, E.

10.1101/2023.01.12.523769 — biophysics — Posted on 2023-01-14

2460 Cryo-tomography reveals rigid-body motion and organization of apicomplexan invasion machinery

Gui, L.; O'Shaughnessy, W. J.; Cai, K.; Reetz, E.; Reese, M. L.; Nicastro, D.

10.1101/2022.04.23.489287 — biophysics — Posted on 2023-01-14

2461 Driving Forces underlying Selectivity Filter Gating in the MthK Potassium Channel

Kopec, W.; Thomson, A. S.; de Groot, B. L.; Rothberg, B. S.

10.1101/2022.03.29.486236 — biophysics — Posted on 2023-01-14

2462 APPRAISE: Fast, accurate ranking of engineered proteins by receptor binding propensity using structural modeling

Ding, X.; Chen, X.; Sullivan, E. E.; Shay, T. F.; Gradinaru, V.

10.1101/2023.01.11.523680 — bioengineering — Posted on 2023-01-14

2463 DBDA matrix increases ion abundance of fatty acids and sulfatides in MALDI-TOF and mass spectrometry imaging studies

Khamidova, N.; Pergande, M. R.; Pathmasiri, K. C.; Khan, R.; Mohr, J. T.; Cologna, S. M.

10.1101/2023.01.13.524013 — biochemistry — Posted on 2023-01-14

2464 High Throughput Single Cell Proteomic Analysis of Organ Derived Heterogeneous Cell Populations by Nanoflow Dual Trap Single Column Liquid Chromatography

Kreimer, S.; Binek, A.; Chazarin, B.; Cho, J. H.; Haghani, A.; Hutton, A.; Marban, E.; Mastali, M.; Meyer, J. G.; Ribeiro Mesquita, T. R.; Song, Y.; Van Eyk, J.; Parker, S. J.

10.1101/2023.01.06.522908 — biochemistry — Posted on 2023-01-14

2465 Heading direction tracks internally directed selective attention in visual working memory

Thom, J. L.; Nobre, A. C.; van Ede, F.; Draschkow, D.

10.1101/2022.05.04.490654 — animal behavior and cognition — Posted on 2023-01-14

2466 A nanoparticle priming agent reduces cellular uptake of cell-free DNA and enhances the sensitivity of liquid biopsies

Martin Alonso, C.; Tabrizi, S.; Xiong, K.; Blewett, T.; Patel, S.; An, Z.; Sridhar, S.; Bekdemir, A.; Shea, D.; Amini, A. P.; Wang, S.-T.; Kirkpatrick, J.; Rhoades, J.; Golub, T.; Love, J. C.; Adalsteinsson, V.; Bhatia, S.

10.1101/2023.01.13.524003 — genomics — Posted on 2023-01-14

2467 De novo genome assemblies reveal structural variations between laboratory and natural isolates of C. elegans

Bush, Z. D.; Naftaly, A. F. S.; Dinwiddie, D.; Albers, C.; Hillers, K. J.; Libuda, D. E.

10.1101/2023.01.13.523974 — genomics — Posted on 2023-01-14

2468 Relationship between the ACTN3, ACE, AGT, BDKRB2 and IL6 genes and the intake of creatine HCl, whey protein and glutamine, with changes in strength and fat percentage, before an undulating strength program in lower limbs in athletes from Valle del Cauca. Colombia

Gonzalez Estrada, G. D.; Paz, E.; Sanclemente, F.

10.1101/2023.01.14.523685 — genetics — Posted on 2023-01-14

2469 The coupling between mutations effects and environment guides the exploration of the phenotypic space as evidenced in artificial selection experiments

Desbiez-Piat, A.; Ressayre, A.; MARCHADIER, E.; Noly, A.; Bourgais, A.; Galic, N.; Le Guilloux, M.; Tenaillon, M. I.; Dillmann, C.

10.1101/2023.01.13.523786 — evolutionary biology — Posted on 2023-01-14

2470 Oct1 cooperates with Smad transcription factors to promote lineage specification

Perovanovic, J.; Wu, Y.; Abewe, H.; Shen, Z.; Hughes, E. P.; Gertz, J.; Chandrasekharan, M. B.; Tantin, D.

10.1101/2020.12.01.406488 — developmental biology — Posted on 2023-01-14

2471 Listeria monocytogenes requires DHNA-dependent intracellular redox homeostasis facilitated by Ndh2 for survival and virulence

Smith, H. B.; Lee, K.; Stevenson, D. M.; Amador-Noguez, D.; Sauer, J.-D.

10.1101/2023.01.13.524026 — microbiology — Posted on 2023-01-14

2472 Engineered symbiotic bacteria interfering Nosema redox system inhibit microsporidia parasitism in honeybees

Lang, H.; Wang, H.; Wang, H.; Xie, X.; Hu, X.; Zhang, X.; Zheng, H.

10.1101/2023.01.13.524015 — microbiology — Posted on 2023-01-14

2473 Neuronal expression of herpes simplex virus type-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation by activating Jun

Hsu, Z.-S.; Engel, E. A.; Enquist, L. W.; Koyuncu, O. O.

10.1101/2023.01.13.524029 — microbiology — Posted on 2023-01-14

2474 Assembly of gut-derived bacterial communities follows "early-bird" resource utilization dynamics

Aranda-Diaz, A.; Willis, L.; Nguyen, T. H.; Ho, P.-Y.; Vila, J.; Thomsen, T.; Chavez, T.; Yan, R.; Yu, F. B.; Neff, N.; Sanchez, A.; Estrela, S.; Huang, K.

10.1101/2023.01.13.523996 — microbiology — Posted on 2023-01-14

2475 Recovery of the gut microbiome following enteric infection and persistence of antimicrobial resistance genes in specific microbial hosts

Hansen, Z. A.; Vasco, K. A.; Rudrik, J. T.; Scribner, K. T.; Zhang, L.; Manning, S. D.

10.1101/2023.01.13.523990 — microbiology — Posted on 2023-01-14

2476 scDual-Seq of Toxoplasma gondii-infected mouse bone marrow-derived dendritic cells reveals host cell heterogeneity and differential infection dynamics

Hildebrandt, F.; Mohammed, M.; Dziedziech, A.; Bhandage, A.; Divne, A.-M.; Barrenaes, F.; Barragan, A.; Henriksson, J.; Ankarklev, J.

10.1101/2023.01.13.523919 — microbiology — Posted on 2023-01-14

2477 Fitting agent-based models to tumor images using representation learning

Cess, C. G.; Finley, S. D.

10.1101/2023.01.12.523847 — systems biology — Posted on 2023-01-14

2478 Galectin-9 has non-apoptotic cytotoxic activity towards Acute Myeloid Leukemia independent of cytarabine resistance

Choukrani, G.; Visser, N.; Ustyanovska Avtenyuk, N.; Olthuis, M.; Marsman, G.; Ammatuna, E.; Lourens, H. J.; Niki, T.; Huls, G.; Bremer, E.; Wiersma, V. R.

10.1101/2023.01.12.523722 — cancer biology — Posted on 2023-01-14

2479 Screening megasynthetase mutants at high throughput using droplet microfluidics

Pourmasoumi, F.; Hengoju, S.; Beck, K.; Stephan, P.; Klopfleisch, L.; Hoernke, M.; Rosenbaum, M. A.; Kries, H.

10.1101/2023.01.13.523969 — bioengineering — Posted on 2023-01-14

2480 Conserved Roles for the Dynein Intermediate Chain and Ndel1 in Assembly and Activation of Dynein

Okada, K.; Iyer, B. R.; Lammers, L. G.; Gutierrez, P. A.; Li, W.; Markus, S. M.; McKenney, R. J.

10.1101/2023.01.13.523097 — biochemistry — Posted on 2023-01-14

2481 At-home oral bacteria collection using a lollipop-based microfluidic device

Tu, W.-c.; McManamen, A. M.; Su, X.; Jeacopello, I.; Takezawa, M. G.; Hieber, D. L.; Hassan, G. W.; Lee, U. N.; Anana, E. V.; Locknane, M. P.; Stephenson, M. W.; Shinkawa, V. A. M.; Wald, E. R.; DeMuri, G. P.; Adams, K.; Berthier, E.; Thongpang, S.; Theberge, A. B.

10.1101/2023.01.14.524039 — biochemistry — Posted on 2023-01-14

2482 Genome-wide association studies reveal novel loci associated with pyrethroid and organophosphate resistance in Anopheles gambiae s.l.

Lucas, E. R.; Nagi, S. C.; Egyir-Yawson, A.; Essandoh, J.; Dadzie, S.; Chabi, J.; Djogbenou, L. S.; Medjigbodo, A. A.; Edi, C. V.; Ketoh, G. K.; Koudou, B. G.; Van't Hof, A. E.; Rippon, E. J.; Pipini, D.; Harding, N. J.; Dyer, N. A.; Cerdeira, L. T.; Clarkson, C. S.; Kwiatkowski, D.; Miles, A.; Donnelly, M. J.; Weetman, D.

10.1101/2023.01.13.523889 — genomics — Posted on 2023-01-14

2483 SMIM36, a novel and conserved microprotein, is involved in retinal lamination in zebrafish.

Sharma, S.; Ramasamy, S.; Khan, Y.; Joshi, D. C.; Pillai, B.

10.1101/2023.01.14.524032 — developmental biology — Posted on 2023-01-14

2484 Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

Podolsky, M. J.; Kheyfets, B.; Beigh, A. H.; Yang, C. D.; Lizama Valenzuela, C.; Datta, R.; Wolters, P. J.; McManus, M.; Qi, L.; Atabai, K.

10.1101/2023.01.13.523943 — cell biology — Posted on 2023-01-14

2485 The TNF{blacktriangleup}ARE mouse as a model of intestinal fibrosis

Steiner, C. A.; Koch, S. D.; Evanoff, T.; Welch, N.; Kostelecky, R.; Callahan, R.; Murphy, E. M.; Hall, C. H.; Lu, S.; Weiser-Evans, M. C.; Cartwright, I. M.; Colgan, S. P.

10.1101/2023.01.13.523973 — cell biology — Posted on 2023-01-14

2486 Coupling During Collective Cell Migration is Controlled by a Vinculin Mechanochemical Switch

Shoyer, T. C.; Gates, E. M.; Cabe, J. I.; Conway, D. E.; Hoffman, B. D.

10.1101/2023.01.13.523997 — cell biology — Posted on 2023-01-14

2487 Mechanistic modeling with a variational autoencoder for multimodal single-cell RNA sequencing data

Carilli, M. T.; Gorin, G.; Choi, Y.; Chari, T.; Pachter, L.

10.1101/2023.01.13.523995 — biophysics — Posted on 2023-01-14

2488 Automated staging of zebrafish embryos with KimmelNet

Barry, D. J.; Jones, R. A.; Renshaw, M. J.

10.1101/2023.01.13.523922 — developmental biology — Posted on 2023-01-14

2489 The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis

Lupan, B. M.; Solecki, R. A.; Musso, C. M.; Alsina, F. C.; Silver, D. L.

10.1101/2023.01.13.524010 — developmental biology — Posted on 2023-01-14

2490 The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes

Horani, A.; Gupta, D. K.; Xu, J.; Xu, H.; Puga-Molina, L. D. C.; Santi, C.; Ramagiri, S.; Brennen, S. K.; Pan, J.; Huang, T.; Hyland, R. M.; Gunsten, S.; Tzeng, S.-C.; Strahle, J. M.; Mill, P.; Mahjoub, M. R.; Dutcher, S. K.; Brody, S. L.

10.1101/2023.01.13.523966 — cell biology — Posted on 2023-01-14

2491 Age-dependent loss of cohesion protection in human oocytes

Mihalas, B. P.; Pieper, G. H.; Currie, C. E.; Kelly, D. A.; Hartshorne, G. M.; McAinsh, A. D.; Anderson, R. A.; Marston, A. L.

10.1101/2023.01.13.523952 — cell biology — Posted on 2023-01-14

2492 Active compensation for changes in TDH3 expression mediated by direct regulators of TDH3 in Saccharomyces cerevisiae

Vande Zande, P.; Wittkopp, P. J.

10.1101/2023.01.13.523977 — cell biology — Posted on 2023-01-14

2493 Genome-wide CRISPR screen reveals genetic modifiers of Ca2+-mediated cell death

Reyes Gaido, O. E.; Schole, K. L.; Anderson, M. E.; Luczak, E. D.

10.1101/2023.01.13.523980 — cell biology — Posted on 2023-01-14

2494 Incipient parallel evolution of SARS-CoV-2 Deltacron variant in South Brazil

Sant Anna, F. H.; Andreis, T. F.; Salvato, R. S.; Muterle, A. P.; Comerlato, J.; Gregianini, T. S.; Barcellos, R. B.; Godinho, F. M.; Resende, P. C.; Wallau, G. L.; Castro, T. R.; Casarin, B. C.; Vieira, A. A.; Schwarzbold, A. V.; Trindade, P. A.; Giannini, G. L.; Freese, L.; Bristot, G.; Brasil, C. S.; Rocha, B. O.; Martins, P. B.; Oliveira, F. H.; Oosterhout, C. v.; Wendland, E.

10.1101/2022.10.06.511203 — evolutionary biology — Posted on 2023-01-14

2495 Transplantation-based screen uncovers inducers of muscle progenitor cell engraftment across vertebrate species

Tavakoli, S.; Garcia, V.; Gahwiler, E.; Adatto, I.; Rangan, A.; Messemer, K.; Ashrafi Kakhki, S.; Yang, S.; Chan, V.; Manning, M.; Fotowat, H.; Wagers, A.; Zon, L.

10.1101/2023.01.13.523942 — cell biology — Posted on 2023-01-14

2496 Variation in spatial dependencies across the cortical mantle discriminates the functional behaviour of primary and association cortex

Leech, R.; Vos de Wael, R.; Vasa, F.; Xu, T.; Benn, R. A. B.; Scholz, R.; Braga, R.; Milham, M.; Royer, J.; Bernhardt, B.; Jones, E. J.; Jefferies, E.; Margulies, D. S.; Smallwood, J.

10.1101/2023.01.13.523934 — neuroscience — Posted on 2023-01-13

2497 Speos: An ensemble graph representation learning framework to predict core genes for complex diseases

Ratajczak, F.; Joblin, M.; Hildebrandt, M.; Ringsquandl, M.; Falter-Braun, P.; Heinig, M.

10.1101/2023.01.13.523556 — genetics — Posted on 2023-01-13

2498 Promoting extinction or minimizing growth? The impact of treatment on trait trajectories in evolving populations

Raatz, M.; Traulsen, A.

10.1101/2022.06.17.496570 — evolutionary biology — Posted on 2023-01-13

2499 Spatio-temporal remodeling of extracellular matrix orients epithelial sheet folding

Tsuboi, A.; Fujimoto, K.; Kondo, T.

10.1101/2023.01.13.523870 — developmental biology — Posted on 2023-01-13

2500 SEC-TMT facilitates quantitative differential analysis of protein interaction networks

Doron-Mandel, E.; Bokor, B. J.; Ma, Y.; Street, L. A.; Tang, L. C.; Abdou, A. A.; Shah, N. H.; Rosenberger, G.; Jovanovic, M.

10.1101/2023.01.12.523793 — molecular biology — Posted on 2023-01-13

2501 Draft Genome Sequence of Pedococcus sp. Strain 5OH_020 Isolated from California Grassland Soil

Green, M. A.; Alvarez-Aponte, Z. I.; Trotter, V. V.; Taga, M. E.

10.1101/2023.01.13.523987 — microbiology — Posted on 2023-01-13

2502 Genotypic and phenotypic differences among phase-variable colony variants conserved across Gardnerella spp.

Garcia, E. M.; Klimowicz, A. K.; Edupuganti, L.; Topf, M. A.; Bhide, S. R.; Slusser, D. J.; Leib, S. M.; Buck, G. A.; Jefferson, K. K.; Pepperell, C. S.; Dillard, J. P.

10.1101/2023.01.13.523976 — microbiology — Posted on 2023-01-13

2503 Multiomics atlas-assisted discovery of transcription factors enables specific cell state programming

Chung, H. K.; Liu, C.; Casillas, E.; Chick, B.; Mcdonald, B.; Wang, J.; He, P.; Sun, M.; Ma, S.; Chen, D.; Yang, Q.; Hoffmann, F.; Varanasi, S. K.; Tripple, V.; Cho, U. H.; Ho, J.; Hang, Y.; Williams, A.; Wang, Y.; Hargreaves, D.; Kaech, S. M.; Wang, W.

10.1101/2023.01.03.522354 — immunology — Posted on 2023-01-13

2504 Uncertainty aversion predicts the neural expansion of semantic representations

Vives, M.-L.; de Bruin, D.; van Baar, J. M.; FeldmanHall, O.; Bhandari, A.

10.1101/2023.01.13.523818 — neuroscience — Posted on 2023-01-13

2505 NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression

Sim, N.; Li, Y.

10.1101/2023.01.11.523507 — cancer biology — Posted on 2023-01-13

2506 SERS nanowire chip and machine learning enabled instant identification and classification of clinically relevant wild-type and antibiotic resistant bacteria at species and strain level

Das, S.; Saxena, K.; Tinguely, J.-C.; Pal, A.; Wickramasinghe, N. L.; Khezri, A.; Dubey, V. K.; Ahmad, A.; Vivekanandan, P.; Ahmad, R.; Wadduwage, D. N.; Ahluwalia, B. S.; Mehta, D. S.

10.1101/2023.01.12.523744 — biophysics — Posted on 2023-01-13

2507 Functional and structural insights into the interaction and multi-step activation of bacterial ExoY nucleotidyl cyclases toxins by profilin-bound G-actin

Teixeira-Nunes, M.; Retailleau, P.; Raoux-Barbot, D.; Comisso, M.; Missinou, A. A.; Velours, C.; Plancqueel, S.; Ladant, D.; Mechold, U.; Renault, L.

10.1101/2023.01.13.523968 — biophysics — Posted on 2023-01-13

2508 Directional Cell Migration Guided by a Strain Gradient

Yang, F.; Chen, P.; Xie, T.; Shao, Y.; Li, B.; Sun, Y.

10.1101/2021.07.07.451494 — bioengineering — Posted on 2023-01-13

2509 Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of theadrenomedullin2 G protein-coupled receptor

Babin, K. M.; Karim, J. A.; Gordon, P. H.; Lennon, J.; Dickson, A.; Pioszak, A. A.

10.1101/2023.01.13.523955 — biochemistry — Posted on 2023-01-13

2510 Cuticular profiling of insecticide resistant Aedes aegypti

Jacobs, E.; Chrissian, C.; Rankin-Turner, S.; Wear, M.; Camacho, E.; Scott, J. G.; Broderick, N. A.; McMeniman, C. J.; Stark, R. E.; Casadevall, A.

10.1101/2023.01.13.523989 — biochemistry — Posted on 2023-01-13

2511 Transglutaminase mediated asprosin oligomerization allows its tissue storage as fibers

Morcos, Y. A.; Pryymachuk, G.; Luetke, S.; Gerken, A.; Godwin, A. R.; Jowitt, T. A.; Piekarek, N.; Hoffmann, T.; Niehoff, A.; Odenthal, M.; Drebber, U.; Grisk, O.; Ladilov, Y.; Bloch, W.; Callewaert, B.; Paulsson, M.; Hucklenbruch-Rother, E.; Baldock, C.; Sengle, G.

10.1101/2022.01.04.474899 — biochemistry — Posted on 2023-01-13

2512 Incorporating discovery and replication GWAS into summary data Mendelian randomization studies: A review of current methods and a simple, general and powerful alternative

Mounier, N.; Robertson, D. S.; Kutalik, Z.; Dudbridge, F.; Bowden, J.

10.1101/2023.01.12.523708 — genetics — Posted on 2023-01-13

2513 Sex-biased expression is associated with chromatin state in D. melanogaster and D. simulans

Nanni, A. V.; Martinez, N.; Graze, R.; Newman, J. R. B.; Jain, V.; Vlaho, S.; Signor, S.; Nuzhdin, S. V.; Renne, R.; McIntyre, L.

10.1101/2023.01.13.523946 — evolutionary biology — Posted on 2023-01-13

2514 N-terminal Domain Influences Steroid Activation of the Atlantic Sea Lamprey Corticoid Receptor

Katsu, Y.; Lin, X.; Ji, R.; Chen, Z.; Kamisaka, Y.; Bamba, K.; Baker, M. E.

10.1101/2022.10.08.511437 — evolutionary biology — Posted on 2023-01-13

2515 Inorganic phosphate content does not affect oviposition preference in the invasive pest Drosophila suzukii

Olazcuaga, L.; Guilhot, R.; Claret, J.-L.; Rode, N. O.

10.1101/2022.09.09.507340 — ecology — Posted on 2023-01-13

2516 Leftward transfer of a chemosensory polycystin initiates left-dominant calcium signaling for lateralized embryonic development

Tanaka, Y.; Morozumi, A.; Hirokawa, N.

10.1101/2023.01.12.523739 — developmental biology — Posted on 2023-01-13

2517 A circadian-like gene network regulates heterochronic miRNA transcription in C. elegans

Kinney, B.; Sahu, S.; Stec, N.; Hills-Muckey, K.; Adams, D.; Wang, J.; Jaremako, M.; Joshua-Tor, L.; Keil, W.; Hammell, C. M.

10.1101/2022.09.26.509508 — developmental biology — Posted on 2023-01-13

2518 The psychosis risk factor RBM12 encodes a novel repressor of GPCR/cAMP signal transduction

Semesta, K. M.; Garces, A.; Tsvetanova, N. G.

10.1101/2023.01.12.523776 — cell biology — Posted on 2023-01-13

2519 Ribonucleoprotein condensation driven by retrotransposon LINE-1 sustains RNA integrity and translation in mouse spermatocytes

De Luca, C.; Gupta, A.; Bortvin, A.

10.1101/2023.01.09.523313 — molecular biology — Posted on 2023-01-13

2520 Oxidative stress drives mutagenesis through transcription coupled repair in bacteria

Carvajal-Garcia, J.; Samadpour, A. N.; Viera, A. J. H.; Merrikh, H.

10.1101/2022.06.28.497968 — molecular biology — Posted on 2023-01-13

2521 Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection

Bagdonaite, I.; Marinova, I. N.; Rudjord-Levann, A. M.; Pallesen, E. M.; King-Smith, S.; Roemer, T. B.; Chen, Y.-H.; Olofsson, S.; Norden, R.; Bergstrom, T.; Dabelsteen, S.; Wandall, H. H.

10.1101/2022.10.23.513399 — microbiology — Posted on 2023-01-13

2522 Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

Li, J.; Ruggiero-Ruff, R. E.; He, Y.; Qiu, X.; Lainez, N.; Villa, P.; Godzik, A.; Coss, D.; Nair, M. G.

10.1101/2023.01.13.523880 — immunology — Posted on 2023-01-13

2523 Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signalingduring steatohepatitis in diet-induced NAFLD.

LOW, Z. S.; CHUA, D.; CHENG, H. S.; TEE, R.; TAN, W. R.; BALL, C.; SAHIB, N. B. E.; NG, S. S.; QU, J.; LIU, Y.; HONG, H.; CAI, C.; RAO, N. C. L.; WEE, A.; MUTHIAH, M. D.; BICHLER, Z.; MICKELSON, B.; LEE, J. Q.; NG, A. S.; YIP, Y. S.; VOS, M. I. G.; LIM, D. X. E.; CHITTEZHATH, M.; YALIGAR, J.; VERMA, S. K.; POPTANI, H.; GUAN, X. L.; VELAN, S. S.; ALI, Y.; LI, L.; TAN, N. S.; WAHLI, W.

10.1101/2023.01.10.523354 — immunology — Posted on 2023-01-13

2524 Neural responses to instructed positive couple interaction: An fMRI study on compliment sharing

Eckstein, M.; Stoessel, G.; Gerchen, M. F.; Bilek, E.; Kirsch, P.; Ditzen, B.

10.1101/2022.06.15.496238 — neuroscience — Posted on 2023-01-13

2525 A Joint Subspace Mapping Between Structural and Functional Brain Connectomes

Ghosh, S.; Raj, A.; Nagarajan, S.

10.1101/2022.04.12.488055 — neuroscience — Posted on 2023-01-13

2526 Lasting consequences on physiology and social behavior following cesarean delivery in prairie voles

Kenkel, W.; Perkeybile, A. M.; Reinhart, J.; Kingsbury, M.; Carter, C. S.

10.1101/2022.05.22.492927 — neuroscience — Posted on 2023-01-13

2527 A physiologically based model of bile acid metabolism in mice

Kister, B.; Viehof, A.; Rolle-Kampczyk, U.; Schwentker, A.; Treichel, N. S.; Jennings, S.; Wirtz, T.; Blank, L. M.; Hornef, M. W.; von Bergen, M.; Clavel, T.; Kuepfer, L.

10.1101/2022.11.10.515857 — systems biology — Posted on 2023-01-13

2528 Super-resolution mass spectrometry enables rapid, accurate, and highly-multiplexed proteomics at the MS2-level

Kozhinov, A. N.; Johnson, A.; Nagornov, K. O.; Stadlmeier, M.; Martin, W. L.; Dayon, L.; Corthesy, J.; Wuhr, M.; Tsybin, Y. O.

10.1101/2022.07.29.501912 — systems biology — Posted on 2023-01-13

2529 Comparison of the effects of PTH (1-34), PTHrP (1-36) and abaloparatide on the murine osteoblast transcriptome.

Mosca, M. J.; He, Z.; Ricarte, F. R.; Le Henaff, C.; Partridge, N. C.

10.1101/2023.01.11.523646 — physiology — Posted on 2023-01-13

2530 Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia

Cao, L.; Ruiz Buendia, G. A.; Fournier, N.; Liu, Y.; Armand, F.; Hamelin, R.; Pavlou, M.; Radtke, F.

10.1101/2022.12.23.521745 — cancer biology — Posted on 2023-01-13

2531 Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems

Hamis, S.; Somervuo, P.; Agren, J. A.; Tadele, D. S.; Kesseli, J.; Scott, J. G.; Nykter, M.; Gerlee, P.; Finkelshtein, D.; Ovaskainen, O.

10.1101/2022.05.07.491050 — cancer biology — Posted on 2023-01-13

2532 Perinatal folate levels do not influence tumor latency or multiplicity in a model of NF1 associated plexiform-like neurofibromas

Marley, A. R.; Williams, K. B.; Tibbitts, J.; Moertel, C. L.; Johnson, K.; Linden, M. A.; Largaespada, D. A.; Marcotte, E. L.

10.1101/2023.01.13.523962 — cancer biology — Posted on 2023-01-13

2533 Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates

Ranganathan, S.; Dasmeh, P.; Furniss, S.; Shakhnovich, E.

10.1101/2022.09.15.508150 — biophysics — Posted on 2023-01-13

2534 Single-cell Genome-and-Transcriptome sequencing without upfront whole-genome amplification reveals cell state plasticity of melanoma subclones

Theunis, K.; Vanuytven, S.; Rambow, F.; Brown, D.; Vanderhaegen, M.; Marin-Bejar, O.; Rogiers, A.; Vanraemdonck, N.; Leucci, E.; Demeulemeester, J.; Sifrim, A.; Marine, J.-C.; Voet, T.

10.1101/2023.01.13.521174 — genomics — Posted on 2023-01-13

2535 Detection of a reservoir of bedaquiline / clofazimine resistance associated variants in Mycobacterium tuberculosis predating the antibiotic era

van Dorp, L.; Nimmo, C.; Torres Ortiz, A.; Pang, J.; Acman, M.; Tan, C. C.; Millard, J.; Padayatchi, N.; Grant, A.; O'Donnell, M. R.; Pym, A.; Brynildsrud, O. B.; Eldholm, V.; Grandjean, L.; Didelot, X.; Balloux, F.

10.1101/2020.10.06.328799 — genomics — Posted on 2023-01-13

2536 Genomic Analysis of Two Phlebotomine Sand Fly Vectors of Leishmania from the New and Old World

McDowell, M. A.; Labbe, F.; Abdeladhim, M.; Abrudan, J.; Araki, A. S.; Araujo, R. N.; Arensburger, P.; Beniot, J. B.; Brazil, R. P.; Bruno, R. V.; Bueno da Silva Rivas, G.; Carvalho de Abreu, V.; Charamis, J.; Coutinho-Abreu, I.; da Costa-Latge, S. G.; Darby, A.; Dillon, V.; Emrich, S. J.; Fernandez-Medina, D.; Figueiredo Gontijo, N.; Flannley, C. M.; Gatherer, D.; Genta, F. A.; Gesing, S.; Giraldo-Calderon, G. I.; Gomes, B.; Aguiar, E. R. G. R.; Hamarsheh, O.; Hawksworth, M.; Hendershot, J. M.; Hickner, P. V.; Imler, J.-L.; Ioannidis, P.; Jennings, E. C.; Kamhawi, S.; Karageorgiou, C.; Kenned

10.1101/2022.10.05.510924 — genomics — Posted on 2023-01-13

2537 Limited role of generation time changes in driving the evolution of mutation spectrum in humans

Gao, Z.; Zhang, Y.; Cramer, N.; Przeworski, M.; Moorjani, P.

10.1101/2022.06.17.496622 — evolutionary biology — Posted on 2023-01-13

2538 The contrasted impacts of grasshoppers on soil microbial activities in function of primary production and herbivore diet

Ibanez, S.; Foulquier, A.; Brun, C.; Colace, M.-P.; Piton, G.; Bernard, L.; Gallet, C.; Clément, J.-C.

10.1101/2022.07.04.497718 — ecology — Posted on 2023-01-13

2539 Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of Drosophila testes

Raz, A. A.; Vida, G. S.; Stern, S. R.; Mahadevaraju, S.; Fingerhut, J. M.; Viveiros, J. M.; Pal, S.; Grey, J. R.; Grace, M. R.; Berry, C. W.; Li, H.; Janssens, J.; Saelens, W.; Shao, Z.; Hu, C.; Yamashita, Y. M.; Przytycka, T. M.; Oliver, B.; Brill, J. A.; Krause, H. M.; Matunis, E. L.; White-Cooper, H.; DiNardo, S.; Fuller, M. T.

10.1101/2022.07.26.501581 — developmental biology — Posted on 2023-01-13

2540 DMRT1 is a Testis Determining Gene in Rabbits and is Also Essential for Female Fertility

Dujardin, E.; Andre, M.; Dewaele, A.; Mandon-Pepin, B.; Poulat, F.; Frambourg, A.; Thepot, D.; Jouneau, L.; Jolivet, G.; Pailhoux, E.; Pannetier, M.

10.1101/2023.01.13.523925 — developmental biology — Posted on 2023-01-13

2541 A Genetic and Immunohistochemical Analysis of H. Pylori Phenotypes and p27 expression in Adenocarcinoma Patients in Jordan

Al-sheboul, S. A.; Mohammad, A. A. A.-R.; Shboul, Y.; Brown, B.; Matalka, I.

10.1101/2022.12.18.520940 — microbiology — Posted on 2023-01-13

2542 Gac is a transcriptional repressor of the Lyme disease spirochete's OspC virulence-associated surface protein

Castro-Padovani, T. N.; Saylor, T. C.; Husted, O. T.; Krusenstjerna, A. C.; Jusufovic, N.; Stevenson, B.

10.1101/2022.11.09.515855 — microbiology — Posted on 2023-01-13

2543 Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity

Copland, A.; Mackie, G. M.; Scarfe, L.; Lecky, D. A.; Gudgeon, N.; McQuade, R.; Ono, M.; Barthel, M.; Hardt, W.-D.; Ohno, H.; Dimeloe, S.; Bending, D.; Maslowski, K. M.

10.1101/2023.01.12.523780 — immunology — Posted on 2023-01-13

2544 Spatial anchor of adaptive immune cell around biomaterials mediated large-scale wound regeneration

YANG, Y.; CHU, C.; LIU, L.; WANG, C.; Man, Y.

10.1101/2022.03.24.485669 — immunology — Posted on 2023-01-13

2545 Inherent envelope fluctuations in forward masking: Effects of age and hearing loss

Brennan, M.; Svec, A.; Farhadi, A.; Maxwell, B.; Carney, L. H.

10.1101/2022.10.20.513056 — neuroscience — Posted on 2023-01-13

2546 BRAin-wide Neuron quantification Tool reveals strong sexual dimorphism in the evolution of fear memory

Franceschini, A.; Mazzamuto, G.; Checcucci, C.; Chicchi, L.; Fanelli, D.; Costantini, I.; Passani, B.; Silva, B. A.; Pavone, F. S.; Silvestri, L.

10.1101/2022.09.12.507637 — neuroscience — Posted on 2023-01-13

2547 Precise and versatile microplate reader-based analyses of biosensor signals from arrayed microbial colonies

Hartmann, F. S. F.; Weiss, T.; Kastberg, L. L. B.; Workman, C. T.; Seibold, G. M.

10.1101/2022.08.12.503755 — synthetic biology — Posted on 2023-01-13

2548 A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides

Bartmann, K.; Bendt, F.; Dönmez, A.; Haag, D.; Kessel, H. E.; Masjosthusmann, S.; Noel, C.; Wu, J.; Zhou, P.; Fritsche, E.

10.1101/2023.01.12.523741 — pharmacology and toxicology — Posted on 2023-01-13

2549 A natural history of networks: Modeling higher-order interactions in geohistorical data

Rojas, A.; Holmgren, A.; Neuman, M.; Edler, D.; Blocker, C.; Rosvall, M.

10.1101/2022.09.26.509538 — paleontology — Posted on 2023-01-13

2550 Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycle.

Tadimari Prabhakar, A.; James, C. D.; Fontan, C.; Otoa, R.; Wang, X.; Bristol, M. L.; Hill, R. D.; Dubey, A.; Morgan, I. M.

10.1101/2023.01.11.523702 — cancer biology — Posted on 2023-01-13

2551 Z-Flipon Variants reveal the many roles of Z-DNA and Z-RNA in health and disease

Umerenkov, D.; Herbert, A.; Konovalov, D.; Danilova, A.; Beknazarov, N.; Kokh, V.; Fedorov, A.; Poptsova, M.

10.1101/2023.01.12.523822 — genomics — Posted on 2023-01-13

2552 Phenotypic and genotypic adaptation of E. coli to thermal stress is contingent on genetic background

Batarseh, T. N.; Batarseh, S. N.; Rodriguez-Verdugo, A. N.; Gaut, B. S.

10.1101/2023.01.11.523675 — evolutionary biology — Posted on 2023-01-13

2553 Prion-like characteristics of Hepatitis E virus ORF3 protein are associated with virus release and pathogenesis

Wang, Y.; Tian, H.; Shi, N.; Wu, C.; Huang, Y.; Yang, Y.; Ding, Q.; Zheng, X.; Zhao, Q.; Tuite, M.; Chen, H.; Nan, Y.

10.1101/2023.01.13.523929 — microbiology — Posted on 2023-01-13

2554 Single-dose YF17D-vectored Ebola vaccine candidate protects mice against both lethal surrogate Ebola and yellow fever virus challenge

Lemmens, V.; Kelchtermans, L.; Debaveye, S.; Chiu, W.; Vercruysse, T.; Ma, J.; Thibaut, H. J.; Neyts, J.; Sanchez-Felipe, L.; Dallmeier, K.

10.1101/2023.01.13.523888 — immunology — Posted on 2023-01-13

2555 Engineered production of isoprene from the model green microalga Chlamydomonas reinhardtii

Yahya, R. Z.; Wellman, G. B.; Overmans, S.; Lauersen, K. J.

10.1101/2023.01.12.523746 — bioengineering — Posted on 2023-01-13

2556 Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier

Shay, T. F.; Sullivan, E. E.; Ding, X.; Chen, X.; Kumar, S. R.; Goertsen, D.; Brown, D.; Vielmetter, J.; Borsos, M.; Lam, A. W.; Gradinaru, V.

10.1101/2023.01.12.523632 — bioengineering — Posted on 2023-01-13

2557 Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates

Chen, X.; Wolfe, D. A.; Sivadasan Bindu, D.; Zhang, M.; Taskin, N.; Goertsen, D.; Shay, T. F.; Sullivan, E.; Ravindra Kumar, S.; Huang, S.-F.; Arokiaraj, C. M.; Plattner, V.; Campos, L. J.; Mich, J. K.; Monet, D.; Ngo, V.; Ding, X.; Omstead, V.; Weed, N.; Bishaw, Y.; Gore, B. B.; Lein, E. S.; Akrami, A.; Miller, C.; Levi, B. P.; Keller, A.; Ting, J. T.; Fox, A. S.; Eroglu, C.; Gradinaru, V.

10.1101/2023.01.12.523844 — bioengineering — Posted on 2023-01-13

2558 2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified

Neto, N.; Suku, M.; Hoey, D.; Monaghan, M. G.

10.1101/2023.01.13.523892 — bioengineering — Posted on 2023-01-13

2559 The junctional mechanosensor AmotL2 regulates YAP promotor accessibility

Mannion, A. J.; Zhao, H.; Zhang, Y.; von Wright, Y.; Bergman, O.; Saharinen, P.; Holmgren, L.

10.1101/2023.01.13.523596 — cell biology — Posted on 2023-01-13

2560 The mitochondrial multi-omic response to exercise training across tissues

Amar, D.; Gay, N. R.; Jimenez-Morales, D.; Jean Beltran, P. M.; Ramaker, M. E.; Natarajan Raja, A.; Zhao, B.; Sun, Y.; Marwaha, S.; Gaul, D.; Hershman, S. G.; Xia, A.; Lanza, I.; Fernandez, F. M.; Montgomery, S. B.; Hevener, A. L.; Ashley, E.; Walsh, M. J.; Sparks, L. M.; Burant, C. F.; Rector, R. S.; Thyfault, J.; Wheeler, M. T.; Goodpaster, B. H.; Coen, P. M.; Schenk, S.; Bodine, S. C.; Lindholm, M. E.; MoTrPAC Study Group,

10.1101/2023.01.13.523698 — molecular biology — Posted on 2023-01-13

2561 The role of the 5' sensing function of ribonuclease E in cyanobacteria

Hoffmann, U. A.; Lichtenberg, E.; Rogh, S. N.; Bilger, R.; Reimann, V.; Heyl, F.; Backofen, R.; Steglich, C.; Hess, W. R.; Wilde, A.

10.1101/2023.01.13.523895 — microbiology — Posted on 2023-01-13

2562 Interaction of FlhF, SRP-like GTPase with FliF, MS ring component assembling the initial structure of flagella in marine Vibrio

Fukushima, Y.; Homma, M.; Kojima, S.

10.1101/2023.01.12.523874 — microbiology — Posted on 2023-01-13

2563 The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoites

Sanchez, S. G.; Bassot, E.; Cerutti, A.; Nguyen, H. M.; Aïda, A.; Blanchard, N.; Besteiro, S.

10.1101/2023.01.13.523885 — microbiology — Posted on 2023-01-13

2564 Comparison of metabarcoding taxonomic markers to describe fungal communities in fermented foods

Rue, O.; Cotton, M.; Dugat-Bony, E.; Howell, K.; Irlinger, F.; Legras, J.-L.; Loux, V.; Michel, E.; Mounier, J.; Neuveglise, C.; Sicard, D.

10.1101/2023.01.13.523754 — microbiology — Posted on 2023-01-13

2565 Bovine blood and milk T-cell subsets in distinct states of activation and differentiation during subclinical Staphylococcus aureus mastitis

Tucker, N.; Cunha, P.; Gilbert, F. B.; Rambault, M.; Santos, K. R.; Remot, A.; Germon, P.; Rainard, P.; Martins, R. P.

10.1101/2023.01.12.523729 — immunology — Posted on 2023-01-13

2566 Alterations in Germinal Center Formation and B Cell Activation during Severe Orientia tsutsugamushi Infection in Mice

Gonzales, C.; Liang, Y.; Fisher, J.; Card, G.; Sun, J.; Soong, L.

10.1101/2023.01.12.523709 — immunology — Posted on 2023-01-13

2567 Oxygen-induced chromophore degradation in the photoswitchable red fluorescent protein rsCherry

Bui, T. Y. H.; De Zitter, E.; Moeyaert, B.; Pecqueur, L.; Srinivasu, B. Y.; Economou, A.; Fontecave, M.; Van Meervelt, L.; Dedecker, P.; Pedre, B.

10.1101/2023.01.13.523900 — biophysics — Posted on 2023-01-13

2568 A Real-Time Analysis of Protein Transport via the Twin Arginine Translocation Pathway in Response to Different Components of the Protonmotive Force in vivo

Zhou, W.; Hao, B.; Bricker, T. M.; Theg, S. M.

10.1101/2023.01.12.523868 — biochemistry — Posted on 2023-01-13

2569 Can we sort states of environmental DNA (eDNA) from a single sample?

Kirtane, A. A.; Kleyer, H.; Deiner, K.

10.1101/2023.01.13.523867 — molecular biology — Posted on 2023-01-13

2570 Redox-active compound generated by bacterial crosstalk induces hypha branching in Streptomyces species

Kato, M.; Asamizu, S.; Onaka, H.

10.1101/2023.01.12.523877 — microbiology — Posted on 2023-01-13

2571 Temporal pattern recognition in retinal ganglion cells is mediated by dynamical inhibitory synapses

Ebert, S.; Buffet, T.; Sermet, B. S.; Marre, O.; Cessac, B.

10.1101/2023.01.12.523643 — neuroscience — Posted on 2023-01-13

2572 Persistent Extrasynaptic Hyperdopaminergia in the mouse Hippocampus Induces Plasticity and Recognition Memory Deficits Reversed by Antipsychotics

Rocchetti, J.; Fasano, C.; Dal-Bo, G.; Guma, E.; El Mestikawy, S.; Wong, T. P.; Fakhfouri, G.; GIROS, B.

10.1101/2023.01.12.523788 — neuroscience — Posted on 2023-01-13

2573 Task history dictates how the dorsolateral striatum controls action strategy and vigor

Crego, A. C. G.; Amaya, K. A.; Palmer, J. A.; Smith, K. S.

10.1101/2023.01.11.523640 — animal behavior and cognition — Posted on 2023-01-13

2574 Biophysical modeling of the electric field magnitude and distribution induced by electrical stimulation with intracerebral electrodes

Alonso, F.; Mercadal, B.; Salvador, R.; Ruffini, G.; Bartolomei, F.; Wendling, F.; Modolo, J.

10.1101/2023.01.13.523921 — neuroscience — Posted on 2023-01-13

2575 Distributed representations of prediction error signals across the cortical hierarchy are synergistic

Gelens, F.; Komatsu, M.; Uran, C.; Jensen, M. A.; Miller, K. J.; Ince, R. A. A.; Vinck, M.; Canales-Johnson, A.

10.1101/2023.01.12.523735 — neuroscience — Posted on 2023-01-13

2576 The neural activity of auditory conscious perception

Christison-Lagay, K. L.; Freedman, N. C.; Micek, C.; Khalaf, A.; Kronemer, S. I.; Gusso, M. M.; Kim, L.; Forman, S.; Ding, J.; Aksen, M.; Abdel-Aty, A.; Kwon, H.; Markowitz, N.; Yeagle, E.; Espinal, E.; Herrero, J.; Bickel, S.; Young, J.; Mehta, A.; Wu, K.; Gerrard, J.; Damisah, E.; Spencer, D.; Blumenfeld, H.

10.1101/2023.01.12.523829 — neuroscience — Posted on 2023-01-13

2577 Reactivation of the progenitor gene Trim71 enhances the mitotic and hair cell-forming potential of cochlear supporting cells

Li, X.-J.; Morgan, C.; Nadar-Ponniah, P. T.; Kolanus, W.; Doetzlhofer, A.

10.1101/2023.01.12.523802 — neuroscience — Posted on 2023-01-13

2578 Localization and connectivity of rodent equivalent of the primate posterior cingulate cortex (area 23)

Xiang, X.-J.; Chen, S.-Q.; Zhang, X.-Q.; Chen, C.-H.; Zhang, S.-Y.; Cai, H.-R.; Ding, S.-L.

10.1101/2023.01.11.523665 — neuroscience — Posted on 2023-01-13

2579 What humans learn from corrective feedback for perceptual decision-making

Lee, H.-J.; Lee, H.; Lim, C. Y.; Rhim, I.; Lee, S.-H.

10.1101/2023.01.11.523567 — neuroscience — Posted on 2023-01-13

2580 Top-down control of exogenous attentional selection is mediated by beta coherence in prefrontal cortex

Dubey, A.; Markowitz, D.; Pesaran, B.

10.1101/2023.01.11.523664 — neuroscience — Posted on 2023-01-13

2581 A Role For Astrocytic Insulin-Like Growth Factor I Receptors In The Response To Ischemic Insult

Suda, K.; Pignatelli, J.; Genis, L.; Fernandez, A. M.; Fernandez de Sevilla, M. E.; Fernandez de la Cruz, I.; Pozo-Rodrigalvarez, A.; de Ceballos, M. L.; Diaz-Pacheco, S.; Herrero-Labrador, R.; Torres Aleman, I.

10.1101/2023.01.13.523904 — neuroscience — Posted on 2023-01-13

2582 From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions

Tiane, A.; Schepers, M.; Reijnders, R. A.; van Veggel, L.; Chenine, S.; Rombaut, B.; Dempster, E.; Verfaillie, C.; Wasner, K.; Grunewald, A.; Prickaerts, J.; Pishva, E.; Hellings, N.; van den Hove, D.; Vanmierlo, T.

10.1101/2023.01.12.523740 — neuroscience — Posted on 2023-01-13

2583 Real-time feedback reduces participant motion during task-based fMRI

Rogers, C. S.; Jones, M. S.; McConkey, S.; McLaughlin, D. J.; Peelle, J. E.

10.1101/2023.01.12.523791 — neuroscience — Posted on 2023-01-13

2584 Myricetin protected against Aβ oligomer-induced synaptic impairment, mitochondrial function and oxidative stress in SH-SY5Y cells via ERK1/2/GSK-3β pathways

Wang, L.; Tang, Z.; Deng, Y.; Peng, Y.; Xiao, Y.; Xu, J.; Ni, R.; Qi, X.

10.1101/2023.01.12.523781 — neuroscience — Posted on 2023-01-13

2585 Ketolysis is Required for the Proper Development and Function of the Somatosensory Nervous System.

Enders, J.; Jack, J.; Thomas, S.; Lynch, P.; Lasnier, S.; Cao, X.; Swanson, M. T.; Ryals, J. M.; Thyfault, J. P.; Puchalska, P.; Crawford, P. A.; Wright, D. E.

10.1101/2023.01.11.523492 — neuroscience — Posted on 2023-01-13

2586 Evidence for adaptive myelination of subcortical shortcuts for visual motion perception in healthy adults

Rowe, E.; Zhang, Y.; Garrido, M.

10.1101/2023.01.11.523655 — neuroscience — Posted on 2023-01-13

2587 Micromotion derived fluid shear stress mediates peri-electrode gliosis through mechanosensitive ion channels

Trotier, A. F.; Bagnoli, E.; Walski, T.; Evers, J.; Pugliese, E.; Lowery, M. M.; Kilcoyne, M.; Fitzgerald, U.; Biggs, M.

10.1101/2023.01.13.523766 — neuroscience — Posted on 2023-01-13

2588 The detection of brood parasitism and quasi-parasitism in the burying beetle Nicrophorus quadripunctatus under natural conditions

Niida, T.; Yao, I.; Nisimura, T.; Suzuki, S.

10.1101/2023.01.11.523691 — animal behavior and cognition — Posted on 2023-01-13

2589 A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line.

Venuto, A.; Thibodeau-Beganny, S.; Trapani, J. G.; Erickson, T.

10.1101/2023.01.12.523756 — animal behavior and cognition — Posted on 2023-01-13

2590 Observing Aggression Increases Aggression In Semi-Free Ranging Barbary Macaques

Blood, R. A.; Semple, S.

10.1101/2023.01.12.523737 — animal behavior and cognition — Posted on 2023-01-13

2591 Millisecond-scale behaviours of plankton quantified in situ and in vitro using the Event-based Vision Sensor (EVS)

Takatsuka, S.; Miyamoto, N.; Sato, H.; Morino, Y.; Kurita, Y.; Yabuki, A.; Chen, C.; Kawagucci, S.

10.1101/2023.01.11.523686 — animal behavior and cognition — Posted on 2023-01-13

2592 spinDrop: a droplet microfluidic platform to maximise single-cell sequencing information content

de Jonghe, J.; Kaminski, T. S.; Morse, D.; Tabaka, M.; Ellermann, A. L.; Kohler, T. N.; Amadei, G.; Handford, C.; Findlay, G.; Zernicka-Goetz, M.; Teichmann, S.; Hollfelder, F.

10.1101/2023.01.12.523500 — developmental biology — Posted on 2023-01-13

2593 Convergence of direction, location and theta in the rat anteroventral thalamic nucleus

Lomi, E.; Jeffery, K.; Mitchell, A.

10.1101/2023.01.11.523585 — neuroscience — Posted on 2023-01-13

2594 Fast 2-photon stimulation using holographic patterns

Brunstein, M.; Lubetzki, J.; Li, W.; Moutoussamy, C.; Barral, J.

10.1101/2023.01.12.523269 — neuroscience — Posted on 2023-01-13

2595 Pupil dilation scales with movement distance of real but not of imagined reaching movements

Voudouris, D.; Schuetz, I.; Schinke, T.; Fiehler, K.

10.1101/2023.01.11.521813 — neuroscience — Posted on 2023-01-13

2596 The dietary polyphenol metabolite protocatechuic acid produces acute and sustained effects on hippocampal electrical activity

Montero-Atalaya, M.; Munoz-Arnaiz, R.; Makarova, J.; Bartolome, B.; Moreno-Arribas, V.; Herreras, O.

10.1101/2023.01.12.523723 — neuroscience — Posted on 2023-01-13

2597 Different rules for binocular combination of luminance flicker in cortical and subcortical pathways

Segala, F. G.; Bruno, A.; Aung, M. T.; Wade, A. R.; Baker, D. H.

10.1101/2023.01.11.523568 — neuroscience — Posted on 2023-01-13

2598 Neural evidence for boundary updating as the source of the repulsive bias in classification

Lee, H.; Lee, H.-J.; Choe, K. W.; Lee, S.-H.

10.1101/2023.01.11.523692 — neuroscience — Posted on 2023-01-13

2599 Assessing spontaneous sensory neuron activity using in vivo calcium imaging

Ingram, S. L.; Chisholm, K. I.; Wang, F.; Denk, F.; De Koninck, Y.; Goodwin, G. L.

10.1101/2023.01.12.523728 — neuroscience — Posted on 2023-01-13

2600 Cortical beta power reflects a neural implementation of decision boundary collapse in a speeded flanker task

Kirschner, H.; Fischer, A. G.; Danielmeier, C.; Klein, T. A.; Ullsperger, M.

10.1101/2023.01.13.523918 — neuroscience — Posted on 2023-01-13

2601 A tachykinin precursor 1 medullary circuit promoting rhythmic breathing

Rousseau, J.-P.; Furdui, A.; da Silveira Scarpellini, C.; Horner, R. L.; Montandon, G.

10.1101/2023.01.13.523897 — neuroscience — Posted on 2023-01-13

2602 Area postrema neurons mediate interleukin-6 function in cancer-associated cachexia

Li, B.; Sun, Q.; van de Lisdonk, D.; Ferrer, M.; Gegenhuber, B.; Wu, M.; Tollkuhn, J.; Janowitz, T.

10.1101/2023.01.12.523716 — neuroscience — Posted on 2023-01-13

2603 Enhancing glymphatic function with very low-intensity ultrasound via the transient receptor potential vanilloid-4-aquaporin-4 pathway

Liao, W.-H.; Wu, C.-H.; Chu, Y.-C.; Hsiao, M.-Y.; Kung, Y.; Wang, J.-L.; Chen, W.-S.

10.1101/2023.01.13.523878 — neuroscience — Posted on 2023-01-13

2604 A novel head-fixed assay for social touch in mice uncovers aversive responses in two autism models.

Chari, T.; Hernandez, A.; Portera-Cailliau, C.

10.1101/2023.01.11.523491 — neuroscience — Posted on 2023-01-13

2605 Heterogeneity of novel APOER2 isoforms specific to Alzheimer disease impact cellular and synaptic states

Gallo, C. M.; Kistler, S.; Natrakul, A.; Labadorf, A. T.; Beffert, U.; Ho, A.

10.1101/2023.01.12.523804 — neuroscience — Posted on 2023-01-13

2606 Applying joint graph embedding to study Alzheimer's neurodegeneration patterns in volumetric data

He, R.; Tward, D. J.

10.1101/2023.01.11.523671 — neuroscience — Posted on 2023-01-13

2607 Distinct Mechanisms Underlie Electrical Coupling Resonance and Its Interaction with Membrane Potential Resonance

Li, X.; Itani, O.; Bucher, D. M.; Rotstein, H. G.; Nadim, F.

10.1101/2023.01.11.523652 — neuroscience — Posted on 2023-01-13

2608 Individual Variability in Structural Connectivity Architecture of the Human Brain across the Middle-aged and Old Adult

Huang, W.; Dong, X.; Ma, G.; Zhang, Z.; Su, L.; Shu, N.

10.1101/2023.01.11.523683 — neuroscience — Posted on 2023-01-13

2609 Distinguishing response from stimulus driven history biases

Sheehan, T. C.; Serences, J. T.

10.1101/2023.01.11.523637 — neuroscience — Posted on 2023-01-13

2610 Sampling strategies and integrated reconstruction for reducing distortion and boundary slice aliasing in high-resolution 3D diffusion MRI

Li, Z.; Miller, K. L.; Andersson, J. L. R.; Zhang, J.; Liu, S.; Guo, H.; Wu, W.

10.1101/2023.01.11.523645 — neuroscience — Posted on 2023-01-13

2611 Protein aggregation in plant mitochondria inhibits translation and induces an NAC017-dependent ethylene-associated unfolded protein response

Song, C.; Li, Y.; Hou, Y.; Yang, M.; Li, T.; Liu, Y.; Xu, C.; Liu, J.; Millar, H.; Wang, N.; Li, L.

10.1101/2023.01.11.523570 — plant biology — Posted on 2023-01-13

2612 Axial regionalization in Tiktaalik roseae and the origin of quadrupedal locomotion

Stewart, T. A.; Lemberg, J. B.; Hillan, E.; Magallanes, I.; Daeschler, E. B.; Shubin, N. H.

10.1101/2023.01.11.523301 — paleontology — Posted on 2023-01-13

2613 Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

Singh, I.; Li, F.; Fink, E.; Chau, I.; Li, A.; Rodriguez-Hernandez, A.; Glenn, I.; Zapatero-Belinchon, F. J.; Rodriguez, M.; Devkota, K.; Deng, Z.; White, K.; Wan, X.; Tolmachova, N. A.; Moroz, Y. S.; Kaniskan, H. U.; Ott, M.; Gastia-Sastre, A.; Jin, J.; Fujimori, D. G.; Irwin, J. J.; Vedadi, M.; Shoichet, B. K.

10.1101/2023.01.12.523677 — biophysics — Posted on 2023-01-13

2614 Pathogenesis of Breakthrough Infections with SARS-CoV-2 Variants in Syrian Hamsters

Plunkard, J.; Mulka, K.; Zhou, R.; Tarwater, P.; Zhong, W.; Lowman, M.; Wong, A.; Pekosz, A.; Villano, J.

10.1101/2023.01.12.523876 — microbiology — Posted on 2023-01-13

2615 Selectivity for food in human ventral visual cortex

Jain, N.; Wang, A.; Henderson, M. M.; Lin, R.; Prince, J. S.; Tarr, M. J.; Wehbe, L.

10.1101/2022.05.22.492983 — neuroscience — Posted on 2023-01-13

2616 Population demographic history and evolutionary rescue: influence of a bottleneck event

Olazcuaga, L.; Lincke, B.; Delacey, S.; Durkee, L. F.; Melbourne, B. A.; Hufbauer, R. A.

10.1101/2023.01.11.523672 — evolutionary biology — Posted on 2023-01-13

2617 PRDM16 restricts stem cell proliferation by integrating BMP and Wnt signalling in the developing choroid plexus

He, L.; Wen, J.; Dai, Q.

10.1101/2023.01.13.523917 — developmental biology — Posted on 2023-01-13

2618 Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine

Phillips, R. A.; Tuscher, J. J.; Wan, E.; Fitzgerald, N. D.; Zipperly, M. E.; Duke, C. G.; Ianov, L.; Day, J. J.

10.1101/2023.01.12.523845 — neuroscience — Posted on 2023-01-13

2619 Modulation and Neural Correlates of Postmating Sleep Plasticity in Drosophila Females

Duhart, J. M.; Buchler, J. R.; Inami, S.; Kennedy, K. J.; Jenny, B. P.; Afonso, D. J. S.; Koh, K.

10.1101/2023.01.11.523670 — neuroscience — Posted on 2023-01-13

2620 Molecular identification of ALDH1A1 and SIRT2 in the astrocytic putrescine-to-GABA metabolic pathway

Bhalla, M.; Shin, J. I.; Ju, Y. H.; Park, Y. M.; Yoo, S.; Lee, H.; Lee, C. J. J.

10.1101/2023.01.11.523573 — neuroscience — Posted on 2023-01-13

2621 Single nucleus multiome analysis of the prefrontal cortex from C9orf72 ALS/FTD patients illuminates pathways affected during disease progression

Wang, H.-L. V.; Veire, A. M.; Gendron, T. F.; Gearing, M.; Glass, J. D.; Jin, P.; Corces, V. G.; McEachin, Z. T.

10.1101/2023.01.12.523820 — neuroscience — Posted on 2023-01-13

2622 Rice Yellow Mottle Virus resistance by genome editing of the Oryza sativa L. ssp. japonica nucleoporin gene OsCPR5.1 but not OsCPR5.2

Arra, Y.; Auguy, F.; Stiebner, M.; Cheron, S.; Wudick, M. M.; Miras, M.; Schepler-Luu, V.; Cunnac, S.; Frommer, W. B.; Albar, L.

10.1101/2023.01.13.523077 — plant biology — Posted on 2023-01-13

2623 High frequency soil polarization can phenotype crop roots noninvasively

Gu, H.; Cseresnyes, I.; Butnor, J.; Li, B.; Mary, B.; Sun, H.; Zhang, X.; Lu, Y.; Liu, X.

10.1101/2023.01.12.523853 — plant biology — Posted on 2023-01-13

2624 Poison exon annotations improve the yield of clinically relevant variants in genomic diagnostic testing

Felker, S. A.; Lawlor, J. M. J.; Hiatt, S. M.; Thompson, M. L.; Latner, D. R.; Finnila, C. R.; Bowling, K. M.; Bonnstetter, Z. T.; Bonini, K. E.; Kelly, N. R.; Kelley, W. V.; Hurst, A. C. E.; Kelly, M. A.; Nakouzi, G.; Hendon, L. G.; Bebin, E. M.; Kenny, E.; Cooper, G. M.

10.1101/2023.01.12.523654 — genetics — Posted on 2023-01-13

2625 Incorporating discovery and replication GWAS into summary data Mendelian randomization studies: A review of current methods and a simple, general and powerful alternative

Mounier, N.; Robertson, D. S.; Kutalik, Z.; Dudbridge, F.; Bowden, J.

10.1101/2023.01.12.523708 — genetics — Posted on 2023-01-13

2626 Genetic mapping reveals new loci and alleles for flowering time and plant height using the double round-robin population of barley

Cosenza, F.; Shrestha, A.; Van Inghelandt, D.; Casale, F.; Wu, P.-Y.; Weisweiler, M.; Li, J.; Wespel, F.; Stich, B.

10.1101/2023.01.12.523733 — genetics — Posted on 2023-01-13

2627 The phruta R package and salphycon shiny app: increasing access, reproducibility, and transparency in phylogenetic analyses

Roman Palacios, C.

10.1101/2023.01.11.523621 — evolutionary biology — Posted on 2023-01-13

2628 High intraspecies allelic diversity in Arabidopsis NLR immune receptors is associated with higher transcription, gene body hypomethylation, and proximity to transposable elements

Sutherland, C. A.; Prigozhin, D. M.; Monroe, J. G.; Krasileva, K. V.

10.1101/2023.01.12.523861 — plant biology — Posted on 2023-01-13

2629 A paternal signal induces endosperm proliferation upon fertilization in Arabidopsis

Simonini, S.; Bencivenga, S.; Grossniklaus, U.

10.1101/2023.01.12.523779 — plant biology — Posted on 2023-01-13

2630 Repeated adaptation to whole genome duplication in outcrossing Arabidopsis is mediated by mosaic adaptive haplotypes

Bohutinska, M.; Petrikova, E.; Booker, T. R.; Vives Cobo, C.; Vlcek, J.; Sramkova, G.; Postulkova, A.; Hojka, J.; Marhold, K.; Kolar, F.; Yant, L.; Schmickl, R.

10.1101/2023.01.11.523565 — evolutionary biology — Posted on 2023-01-13

2631 Warming-induced range expansion effects on the diversity and composition of the gut microbiome: a case study with two butterflies

Montoya, D.; de Jong, M.

10.1101/2023.01.11.523549 — ecology — Posted on 2023-01-13

2632 Mathematical model of nuclear speckle morphology

Wakao, S.; Saitoh, N.; Awazu, A.

10.1101/2023.01.12.523856 — cell biology — Posted on 2023-01-13

2633 Bidirectional multiciliated cell extrusion is controlled by Notch driven basal extrusion and Piezo 1 driven apical extrusion.

Ventrella, R.; Kim, S. K.; Sheridan, J.; Grata, A. C.; Bresteau, E.; Hassan, O. A.; Suva, E. E.; Walentek, P.; Mitchell, B.

10.1101/2023.01.12.523838 — cell biology — Posted on 2023-01-13

2634 Modeling the Effects of Transcranial Magnetic Stimulation on Spatial Attention

Jing, Y.; Numssen, O.; Weise, K.; Kalloch, B.; Haueisen, J.; Hartwigsen, G.; Knoesche, T.

10.1101/2023.01.11.523548 — neuroscience — Posted on 2023-01-13

2635 Design of amyloidogenic peptide traps

Sahtoe, D. D.; Andrzejewska, E. A.; Han, H. L.; Rennella, E.; Schneider, M. M.; Meisl, G.; Ahlrichs, M.; Decarreau, J.; Nguyen, H.; Kang, A.; Levine, P. M.; Lamb, M.; Li, X.; Bera, A. K.; Kay, L. E.; Knowles, T.; Baker, D.

10.1101/2023.01.13.523785 — synthetic biology — Posted on 2023-01-13

2636 Flat clathrin lattices are linked to metastatic potential in colorectal cancer

Cresens, C.; Solis-Fernandez, G.; Tiwari, A.; Nuyts, R.; Hofkens, J.; Barderas, R.; Rocha, S.

10.1101/2023.01.12.520576 — cancer biology — Posted on 2023-01-13

2637 Inferring membrane properties during clathrin-mediated endocytosis using machine learning

Lin, Z.; Mao, Z.; MA, R.

10.1101/2023.01.11.523591 — biophysics — Posted on 2023-01-13

2638 Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition

Thakur, N.; Ray, A.; Sharp, L.; Jin, B.; Duong, A.; Gopal Pour, N.; Obeng, S.; Wijesekara, A.; Gao, Z.-G.; McCurdy, C.; Jacobson, K. A.; Lyman, E.; Eddy, M.

10.1101/2023.01.11.523010 — biophysics — Posted on 2023-01-13

2639 Piconewton forces mediate GAIN domain dissociation of the latrophilin-3 adhesion GPCR

Zhong, B. L.; Lee, C. E.; Vachharajani, V. T.; Sudhof, T. C.; Dunn, A. R.

10.1101/2023.01.12.523854 — biophysics — Posted on 2023-01-13

2640 A simple computational method to increase axial contrast in multi-wavelength interference microscopy

Tinning, P. W.; Schniete, J. K.; Scrimgeour, R. C.; Koelln, L. S.; Rooney, L. M.; Bushell, T. J.; McConnell, G.

10.1101/2023.01.12.523706 — biophysics — Posted on 2023-01-13

2641 Adsorption of RNA to interfaces of biomolecular condensates enables wetting transitions

Erkamp, N. A.; Farag, M.; Qian, D.; Sneideris, T.; Welsh, T. J.; Ausserwoger, H.; Weitz, D.; Pappu, R. V.; Knowles, T.

10.1101/2023.01.12.523837 — biophysics — Posted on 2023-01-13

2642 Active Learning of the Conformational Ensemble of Proteins using Maximum Entropy VAMPNets

Kleiman, D. E.; Shukla, D.

10.1101/2023.01.12.523801 — biophysics — Posted on 2023-01-13

2643 Equivalence of charge imbalance and external electric fields during free energy calculations of membrane electroporation

Kasparyan, G.; Hub, J. S.

10.1101/2023.01.13.523896 — biophysics — Posted on 2023-01-13

2644 Mass spectrometry-based proteomics imputation using self supervised deep learning

Webel, H.; Niu, L.; Bach Nielsen, A.; Locard-Paulet, M.; Mann, M.; Juhl Jensen, L.; Rasmussen, S.

10.1101/2023.01.12.523792 — bioinformatics — Posted on 2023-01-13

2645 Deep-learning based bioactive peptides generation and screening against Xanthine oxidase

Zhang, H.; Saravanan, K. M.; Zhang, J. Z. H.; Wu, X.

10.1101/2023.01.11.523536 — bioinformatics — Posted on 2023-01-13

2646 Biochemical characterization of a GDP-mannose transporter from Chaetomium thermophilum

Premageetha, G. T. R.; Dhanabalan, K.; Bose, S.; Manjunath, L.; Joseph, D.; Paz, A.; Grandfield, S.; Nayak, V.; Bredeston, L. M.; Abramson, J.; Subramanian, R.

10.1101/2023.01.13.523913 — biochemistry — Posted on 2023-01-13

2647 Major axes of variation in tree demography across global forests

Leite, M. d. S.; McMahon, S. M.; Prado, P. I.; Davies, S. J.; Oliveira, A. A. d.; De Deurwaerder, H. P.; Aguilar, S.; Anderson-Teixeira, K. J.; Aqilah, N.; Bourg, N. A.; Brockelman, W. Y.; Castano, N.; Chang-Yang, C.-H.; Chen, Y.-Y.; Chuyong, G.; Clay, K.; Duque, A.; Ediriweera, S.; Ewango, C. E. N.; Gilbert, G.; Gunatilleke, I. A. U. N.; Gunatilleke, C. V. S.; Howe, R.; Huasco, W. H.; Itoh, A.; Johnson, D. J.; Kenfack, D.; Kral, K.; Leong, Y. T.; Lutz, J. A.; Makana, J.-R.; Malhi, Y.; McShea, W. J.; Mohamad, M.; Nasardin, M.; Nathalang, A.; Parker, G.; Parmigiani, R.; P?rez, R.; Phillips, R.

10.1101/2023.01.11.523538 — ecology — Posted on 2023-01-13

2648 Floral presence and flower identity alter cereal aphid endosymbiont communities on adjacent crops

Zytynska, S. E.; Sturm, S.; Hawes, C.; Weisser, W. E.; Karley, A.

10.1101/2023.01.11.523439 — ecology — Posted on 2023-01-13

2649 IL-17 activation undermines longevity and stress tolerance by inhibiting a protective transcriptional network

Lu, Q.; Vladareanu, I.; Zhao, L.; Nilsson, L.; Henriksson, J.; Chen, C.

10.1101/2023.01.13.523898 — cell biology — Posted on 2023-01-13

2650 Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury

Marchand, T.; Akinnola, K. E.; Takeishi, S.; Maryanovich, M.; Pinho, S.; Saint-Vanne, J.; Birbrair, A.; Lamy, T.; Tarte, K.; Frenette, P.; Gritsman, K.

10.1101/2023.01.12.523842 — cell biology — Posted on 2023-01-13

2651 TGFB1 Induces Fetal Reprogramming and Enhances Intestinal Regeneration

Chen, L.; Dupre, A.; Qiu, X.; Pellon-Cardenas, O.; Walton, K. D.; Wang, J.; Perekatt, A. O.; Hu, W.; Spence, J. R.; Verzi, M. P.

10.1101/2023.01.13.523825 — cell biology — Posted on 2023-01-13

2652 DENND2B activates Rab35 at the intercellular bridge regulating cytokinetic abscission and tetraploidy

Kumar, R.; Francis, V.; Ioannou, M. S.; Aguila, A.; Banks, E.; Kulasekaran, G.; Khan, M.; McPherson, P. S.

10.1101/2023.01.12.523789 — cell biology — Posted on 2023-01-13

2653 VAP-mediated membrane tethering mechanisms implicate ER-PM contact function in pH homeostasis

Hoh, K. L.; Mu, B.; See, T.; Ng, A. Y. E.; Ng, A. Q. E.; Zhang, D.

10.1101/2023.01.12.523872 — cell biology — Posted on 2023-01-13

2654 Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

Doolittle, M. L.; Saul, D.; Kaur, J.; Rowsey, J. L.; Vos, S. J.; Pavelko, K. D.; Farr, J. N.; Monroe, D.; Khosla, S.

10.1101/2023.01.12.523760 — cell biology — Posted on 2023-01-13

2655 Microtubule decay is a driver of neuronal ageing and a promising target for intervention

Okenve-Ramos, P.; Gosling, R.; Chojnowska-Monga, M.; Gupta, K.; Shields, S.; Sanchez-Soriano, N.

10.1101/2023.01.11.523590 — neuroscience — Posted on 2023-01-13

2656 Genomic characterization of multidrug-resistant extended spectrum β-lactamase-producing Klebsiella pneumoniae from clinical samples of a tertiary hospital in South Kivu Province, eastern Democratic Republic of Congo

Irenge, L. M.; Ambroise, J.; Bearzatto, B.; Durant, J.-F.; Bonjean, M.; Gala, J.-L.

10.1101/2023.01.10.523520 — genetics — Posted on 2023-01-13

2657 Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in Staphylococcus aureus

Adolf, L. A.; Müller-Jochim, A.; Kricks, L.; Puls, J.-S.; Lopez, D.; Grein, F.; Heilbronner, S.

10.1101/2023.01.11.523574 — microbiology — Posted on 2023-01-13

2658 Inhibition of Herpes simplex virus and Vesicular stomatitis virus Proliferation by Lactiplantibacillus planterum and star anise Extract Is Associated with Induction of MX gene expression

El-Sayed, M.; Sayed Abdelgeliel, A.; Ghanem, A.; H Alrohaimi, A.; Saeed Alzahrani, S.; Fayad, E.; A Alghamdi, M.; Badawy, I.; Bastawy, A.; Elebeedy, D.

10.1101/2023.01.11.523569 — microbiology — Posted on 2023-01-13

2659 Anthracyclines inhibit SARS-CoV-2 infection

Wang, Z.; Pan, Q.; Ma, L.; Zhao, J.; McIntosh, F.; Liu, Z.; Ding, S.; Lin, R.; Shan, C.; Finzi, A.; Liang, C.

10.1101/2023.01.10.523518 — microbiology — Posted on 2023-01-13

2660 OpaR exerts a dynamic control over c-di-GMP homeostasis and cpsA expression in V. parahaemolyticus through its regulation of ScrC and the trigger phosphodiesterase TpdA.

Zamorano-Sanchez, D.; Alejandre-Sixtos, J. E.; Arredondo-Hernandez, A.; Martinez-Mendez, R.

10.1101/2023.01.10.523516 — microbiology — Posted on 2023-01-13

2661 A precision overview of genomic resistance screening in isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.

Morey-Leon, G.; Mejia-Ponce, P. M.; Granda Pardo, J. C.; Munoz-Mawyin, K.; Fernandez-Cadena, J. C.; Garcia-Moreira, E.; Andrade-Molina, D.; Licona-Cassani, C.; Berna, L.

10.1101/2023.01.10.523521 — microbiology — Posted on 2023-01-13

2662 Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity.

Colbert, J. F.; Kirsch, J. M.; Erzen, C. L.; Langouët-Astrie, C. J.; Thompson, G. E.; McMurtry, S. A.; Kofonow, J. M.; Robertson, C.; Kovacs, E. J.; Sullivan, R. C.; Hippensteel, J. A.; Sawant, N. V.; De Nisco, N. J.; McCollister, B. D.; Schwartz, R. S.; Horswill, A. R.; Frank, D.; Duerkop, B. A.; Schmidt, E. P.

10.1101/2023.01.10.523523 — microbiology — Posted on 2023-01-13

2663 Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

Gerke, C.; Bauersfeld, L.; Oberhardt, V.; Jürges, C.; Spaapen, R.; Mussolino, C.; Le-Trilling, V. T. K.; Trilling, M.; Dölken, L.; Erhard, F.; Hofmann, M.; Hengel, H.; Momburg, F.; Halenius, A.

10.1101/2023.01.10.523457 — microbiology — Posted on 2023-01-13

2664 Study on Spatio-temporal Prevalence and Hematological Attributes of Bovine Babesiosis in Cattle Population of Layyah, Southern Punjab, Pakistan

Lashari, M. H.; Ahmad, H.; Rehman, Z.-U.-

10.1101/2023.01.09.523272 — immunology — Posted on 2023-01-13

2665 Distinct representations of innate and learned threats within the thalamic-amygdala pathway

Khalil, V.; Faress, I.; Mermet-Joret, N.; Kerwin, P.; Yonehara, K.; Nabavi, S.

10.1101/2023.01.10.523445 — neuroscience — Posted on 2023-01-13

2666 Identification of factors mediating the signaling convergenceof multiple receptors following cell-cell interaction

Sheinin, R.; Dulberg, S.; Kaminitz, A.; Madi, A.; Sharan, R.

10.1101/2022.06.27.497758 — bioinformatics — Posted on 2023-01-13

2667 Bridging Transcriptome Regulation and Cellular Operational Efficiency with the Locality and Caching System Optimization Principles

Jiang, W.; Feliers, D.; Zheng, W. J.; Zhang, F.; Wang, D.

10.1101/2022.01.11.475967 — systems biology — Posted on 2023-01-13

2668 Phenotype integration improves power and preserves specificity in biobank-based genetic studies of MDD

Dahl, A.; Thompson, M.; An, U.; Krebs, M. D.; Appadurai, V.; Border, R.; Bacanu, S.-A.; Werge, T.; Flint, J.; Schork, A. J.; Sankararaman, S.; Kendler, K.; Cai, N.

10.1101/2022.08.15.503980 — genetics — Posted on 2023-01-13

2669 Probabilistic embedding, clustering, and alignment for integrating spatial transcriptomics data with PRECAST

Liu, W.; Liao, X.; Luo, Z.; Yang, Y.; Lau, M. C.; Jiao, Y.; Shi, X.; Zhai, W.; Ji, H.; Yeong, J.; Liu, J.

10.1101/2022.06.26.497672 — genomics — Posted on 2023-01-13

2670 APOE3 Christchurch modulates tau phosphorylation and regulates β-catenin/Wnt/Cadherin signaling in induced pluripotent stem cell-derived cerebral organoids from Alzheimer's cases

Mazzarino, R. C.; Perez-Corredor, P. A.; Vanderleest, T. E.; Vacano, G. N.; Sanchez, J.; Villalba-Moreno, N. D.; Krasemann, S.; Mendivil Perez, M. A.; Aguillon, D.; Jimenez-Del-Rio, M.; Baena, A.; Sepulveda-Falla, D.; Lopera-Restrepo, F.; Quiroz-Gaviria, Y.; Arboleda-Velasquez, J. F.

10.1101/2023.01.11.523290 — neuroscience — Posted on 2023-01-13

2671 Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer

Yan, W.; Steele, N. G.; Kemp, S. B.; Menjivar, R. E.; Du, W.; Carpenter, E. S.; Donahue, K. L.; Brown, K. L.; Irizarry-Negron, V.; Yang, S.; Burns, W. R.; Zhang, Y.; Pasca di Magliano, M.; Bednar, F.

10.1101/2023.01.11.523584 — cancer biology — Posted on 2023-01-13

2672 Mechanisms of HIV-1 Integrase Resistance to Dolutegravir and Potent Inhibition of Drug Resistant Variants

Li, M.; Passos, D.; Shan, Z.; Smith, S. J.; Sun, Q.; Biswas, A.; Choudhuri, I.; Strutzenberg, T.; Haldane, A.; Deng, N.; Li, Z.; Zhao, X.-Z.; Burke, T. R.; Levy, R. M.; Hughes, S. H.; Craigie, R.; Lyumkis, D.

10.1101/2022.12.04.519057 — biophysics — Posted on 2023-01-12

2673 Urine proteomic analysis of the rat e-cigarette model

Liu, Y.; Shen, Z.; Zhao, C.; Gao, Y.

10.1101/2022.11.19.517186 — biochemistry — Posted on 2023-01-13

2674 CoVar: A generalizable machine learning approach to identify the coordinated regulators driving variational gene expression

Roy, S.; Sheikh, S.; Furey, T.

10.1101/2023.01.12.523808 — genetics — Posted on 2023-01-13

2675 Modeling the Diverse Effects of Divisive Normalization on Noise Correlations

Weiss, O.; Bounds, H. A.; Adesnik, H.; Coen-Cagli, R.

10.1101/2022.06.08.495145 — neuroscience — Posted on 2023-01-12

2676 A novel regulatory mechanism of actin cytoskeleton dynamics through a neural microexon in DAAM1 is necessary for memory formation

Polinski, P.; Miret-Cuesta, M.; Zamora-Moratalla, A.; Mantica, F.; Cantero-Recasens, G.; Normanno, D.; Iniguez-Rabago, L.; Morenilla-Palao, C.; Ordono, P.; Bonnal, S.; Gomez-Riera, R.; De Lagran, M. M.; Fernandez-Blanco, A.; Rodriguez-Marin, C.; Permanyer, J.; Folsz, O.; Sierra, C.; Legutko, D.; Wojnacki, J.; Musoles-Lleo, J. L.; Herrera, E.; Dierssen, M.; Irimia, M.

10.1101/2023.01.12.523772 — neuroscience — Posted on 2023-01-12

2677 Goal-seeking compresses neural codes for space in the human hippocampus and orbitofrontal cortex

Muhle-Karbe, P. S.; Sheahan, H.; Pezzulo, G.; Spiers, H. J.; Chien, S.; Schuck, N. W.; Summerfield, C.

10.1101/2023.01.12.523762 — neuroscience — Posted on 2023-01-12

2678 Restructuring of an asymmetric neural circuit during associative learning

Tang, L. T. H.; Lee, G. A.; Cook, S. J.; Ho, J.; Potter, C. C.; Buelow, H. E.

10.1101/2023.01.12.523604 — neuroscience — Posted on 2023-01-13

2679 Behavioral and transcriptomic changes following brain-specific loss of noradrenergic transmission.

Isingrini, E.; Guinaudie, C.; Perret, L.; Guma, E.; Gorgievski, V.; Blum, I. D.; Colby-Milley, J.; Bairachnaya, M.; Mella, S.; Adamantidis, A.; Storch, F. K.; GIROS, B.

10.1101/2023.01.12.523778 — neuroscience — Posted on 2023-01-13

2680 The autism-associated loss of δ-catenin functions disrupts social behaviors

Mendez-Vazquez, H.; Roach, R. L.; Nip, K.; Sathler, M. F.; Garver, T.; Danzman, R. A.; Moseley, M. C.; Roberts, J. P.; Koch, O. N.; Steger, A. A.; Lee, R.; Arikkath, J.; Kim, S.

10.1101/2023.01.12.523372 — neuroscience — Posted on 2023-01-13

2681 A time-series analysis of blood-based biomarkers within a 25-year longitudinal dolphin cohort.

Rangan, A. V.; McGrouther, C. C.; Bhadra, N.; Schork, N.

10.1101/2022.06.28.497095 — bioinformatics — Posted on 2023-01-12

2682 Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

Lazaro-Pena, M.; Cornwell, A. B.; Diaz-Balzac, C. A.; Das, R.; Macoretta, N.; Thakar, J.; Samuelson, A.

10.1101/2023.01.11.523661 — genetics — Posted on 2023-01-12

2683 Dominant-negative mutations in CBX1 cause a neurodevelopmental disorder

Kuroda, Y.; Iwata-Otsubo, A.; Dias, K.-R.; Lindsay-Temple, S.; Nagao, K.; De Hayr, L.; Zhu, Y.; Isobe, S.-Y.; Nishibuchi, G.; Fiordaliso, S.; Fujita, Y.; Rippert, A. L.; Baker, S. W.; Leung, M. L.; Koboldt, D. C.; Harman, A.; Keena, B. A.; Kazama, I.; Musuwadi Subramanian, G.; Manickam, K.; Schmalz, B.; Latsko, M.; Zackai, E.; Edwards, M.; Evans, C.-A.; Dulik, M. C.; Buckley, M. F.; Yamashita, T.; O'Brien, W. T.; Harvey, R. J.; Obuse, C.; Roscioli, T.; Izumi, K.

10.1101/2020.09.29.319228 — genetics — Posted on 2023-01-12

2684 High-throughput single-cell sequencing of multiple invertible promoters reveals a strong determinant of bacterial population heterogeneity

Lan, F.; Saba, J.; Qian, Y.; Ross, T. D.; Landick, R.; Venturelli, O. S.

10.1101/2022.10.31.514637 — systems biology — Posted on 2023-01-12

2685 Selection of optimal cell lines for high-content phenotypic screening

Heinrich, L.; Kumbier, K.; Li, L.; Altschuler, S.; Wu, L.

10.1101/2023.01.11.523662 — pharmacology and toxicology — Posted on 2023-01-12

2686 A novel role of USP7 in imparting partial EMT state in colorectal cancer through the DDX3X-β-catenin axis

Basu, B.; Karmakar, S.; Basu, M.; Ghosh, M. K.

10.1101/2023.01.11.523622 — cancer biology — Posted on 2023-01-12

2687 Activation Dynamics of Ubiquitin Specific Protease 7

Valles, G. J.; Jaiswal, N.; Korzhnev, D. M.; Bezsonova, I.

10.1101/2023.01.11.523550 — biophysics — Posted on 2023-01-12

2688 Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum

Htet, P. H.; Avezov, E.; Lauga, E.

10.1101/2023.01.11.523552 — biophysics — Posted on 2023-01-12

2689 Computational investigation of the effect of reduced dynein velocity and reduced cargo diffusivity on slow axonal transport

Kuznetsov, I. A.; Kuznetsov, A. V.

10.1101/2022.10.14.512302 — biophysics — Posted on 2023-01-12

2690 Pressure and ultrasound activate mechanosensitive TRAAK K+ channels through increased membrane tension

Sorum, B.; Docter, T.; Panico, V.; Rietmeijer, R. A.; Brohawn, S. G.

10.1101/2023.01.11.523644 — biophysics — Posted on 2023-01-12

2691 Deep learning prediction boosts phosphoproteomics-based discoveries through improved phosphopeptide identification

Yi, X.; Bo, W.; Ji, S.; Saltzman, A. B.; Jaehnig, E. J.; Lei, J. T.; Gao, Q.; Zhang, B.

10.1101/2023.01.11.523329 — bioinformatics — Posted on 2023-01-12

2692 Selection of Extended CRISPR RNAs with Enhanced Targeting and Specificity

Herring-Nicholas, A.; Dimig, H.; Roesing, M.; Josephs, E. A.

10.1101/2023.01.11.523593 — bioengineering — Posted on 2023-01-12

2693 Identifying the suite of genes central to swimming in the biocontrol bacteria Pseudomonas protegens Pf-5

Fabian, B. K.; Foster, C.; Asher, A.; Hassan, K. A.; Paulsen, I. T.; Tetu, S. G.

10.1101/2023.01.12.523705 — genomics — Posted on 2023-01-12

2694 Activator-blocker model of transcriptional regulation by pioneer-like factors

Riesle, A. J.; Gao, M.; Rosenblatt, M.; Hermes, J.; Hass, H.; Gebhard, A.; Veil, M.; Gruening, B.; Timmer, J.; Onichtchouk, D.

10.1101/2023.01.11.523615 — developmental biology — Posted on 2023-01-12

2695 Cystin is required for maintaining fibrocystin (FPC) levels and safeguarding proteome integrity in mouse renal epithelial cells A mechanistic connection between the kidney defects in cpk mice and human ARPKDRunning title: Cystin deficiency results in FPC degradation

Zhang, Y.; Yang, C.; Wang, W.; Haraffuji, N.; Stasiak, P.; Bell, D. P.; Sztul, E.; Caldovic, L.; Guay-Woodford, L. M.; Bebok, Z.

10.1101/2022.04.19.488799 — cell biology — Posted on 2023-01-12

2696 Development of novel cytoprotective small compounds inhibiting mitochondria-dependent apoptosis

Matsuyama, S.; Matsuyama, M.; Ortega, J.; Fedorov, Y.; Scott-McKean, J.; Muller-Greven, J.; Buck, M.; Adams, D.; Jastrzebska, B.; Greenlee, W.

10.1101/2022.10.12.511987 — cell biology — Posted on 2023-01-12

2697 Armadillo repeat-containing kinesin represents the versatile plus-end-directed transporter in Physcomitrella

Yoshida, M. W.; Hakozaki, M.; Goshima, G.

10.1101/2022.07.08.499244 — cell biology — Posted on 2023-01-12

2698 Class switching is differentially regulated in RBC alloimmunization and vaccination

Prakash, A.; Medved, J.; Arneja, A.; Niebuhr, C.; Li, A. N.; Tarrah, S.; Boscia, A. R.; Burnett, E. D.; Singh, A.; Salazar, J. E.; Xu, W.; Santhanakrishnan, M.; Hendrickson, J. E.; Luckey, C. J.

10.1101/2023.01.11.523608 — immunology — Posted on 2023-01-12

2699 Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function

Bormann, A.; Koerner, M. B.; Dahse, A.-K.; Glaeser, M. S.; Irmer, J.; Lede, V.; Alenfelder, J.; Lehmann, J.; Hall, D. C. N.; Thane, M.; Schleyer, M.; Kostenis, E.; Schoeneberg, T.; Bigl, M.; Langenhan, T.; Ljaschenko, D.; Scholz, N.

10.1101/2023.01.11.521585 — neuroscience — Posted on 2023-01-12

2700 Thermal cycling-hyperthermia ameliorates cognitive impairment of intracerebroventricular Aβ25-35-induced Alzheimer's disease in C57BL/6 mice

Kuo, Y.-Y.; Chen, W.-T.; Lin, G.-B.; Chen, Y.-M.; Liu, H.-H.; Chao, C.-Y.

10.1101/2022.07.22.500895 — neuroscience — Posted on 2023-01-12

2701 Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling

Leung, A.; Rangamani, P.

10.1101/2022.08.17.504291 — systems biology — Posted on 2023-01-12

2702 Temperature-Sensitive Contact Modes Allosterically Gate TRPV3

Burns, D.; Venditti, V.; Potoyan, D. A.

10.1101/2023.01.02.522497 — biophysics — Posted on 2023-01-12

2703 NAPS: Integrating pose estimation and tag-based tracking

Wolf, S. W.; Ruttenberg, D. M.; Knapp, D. Y.; Webb, A. E.; Traniello, I. M.; McKenzie-Smith, G. C.; Leheny, S. A.; Shaevitz, J. W.; Kocher, S. D.

10.1101/2022.12.07.518416 — animal behavior and cognition — Posted on 2023-01-12

2704 Genomics of secondarily temperate adaptation in the only non-Antarctic icefish

Rivera-Colon, A. G.; Rayamajhi, N.; Minhas, B. F.; Madrigal, G.; Bilyk, K. T.; Yoon, V.; Hüne, M.; Gregory, S.; Cheng, C.- H. C.; Catchen, J. M.

10.1101/2022.08.13.503862 — genomics — Posted on 2023-01-12

2705 G Protein-Coupled Receptor Kinase-2 (GRK-2) controls exploration through neuropeptide signaling in Caenorhabditis elegans

Davis, K.; Mitchell, C.; Weissenfels, O.; Bai, J.; Raizen, D. M.; Ailion, M.; Topalidou, I.

10.1101/2022.11.05.515252 — genetics — Posted on 2023-01-12

2706 Inorganic phosphate content does not affect oviposition preference in the invasive pest Drosophila suzukii

Olazcuaga, L.; Guilhot, R.; Claret, J.-L.; Rode, N. O.

10.1101/2022.09.09.507340 — ecology — Posted on 2023-01-12

2707 Machine-guided cell-fate engineering

Appleton, E. M.; Tao, J.; Fonseca, G. J.; Liu, S.; Glass, C. H.; Church, G. M.

10.1101/2022.10.14.512279 — developmental biology — Posted on 2023-01-12

2708 Local angiogenic interplay of Vegfc/d and Vegfa drives brain region-specific development of fenestrated capillaries

Parab, S.; Card, O. A.; Chen, Q.; Buck, L. D.; Quick, R. E.; Horrigan, W. F.; Levkowitz, G.; Vanhollebeke, B.; Matsuoka, R. L.

10.1101/2022.12.08.519692 — developmental biology — Posted on 2023-01-12

2709 Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer

Achinger-Kawecka, J.; Stirzaker, C.; Chia, K.-M.; Portman, N.; Campbell, E.; Du, Q.; Laven-Law, G.; Nair, S.; Yong, A.; Wilkinson, A.; Clifton, S.; Milioli, H. H.; Alexandrou, S.; Caldon, C. E.; Song, J.; Khoury, A.; Meyer, B.; Gee, J. M. W.; Schmitt, A.; Wong, E.; Hickey, T.; Lim, E.; Clark, S.

10.1101/2021.06.21.449340 — molecular biology — Posted on 2023-01-12

2710 Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

Chan, A. W.; Broncel, M.; Haseley, N. R.; Chakladar, S.; Andree, E.; Herneisen, A. L.; Shortt, E.; Treeck, M.; Lourido, S.

10.1101/2023.01.11.523553 — microbiology — Posted on 2023-01-12

2711 iTie controls intestinal tolerance through suppressing the NLRP6 inflammasome

Qin, X.; Zhu, F.; Li, W.; Wang, S.; Xia, P.

10.1101/2023.01.12.523719 — immunology — Posted on 2023-01-12

2712 Palmitoylation controls the stability of 190 kDa Ankyrin-G in dendritic spines and is regulated by ZDHHC8 and lithium.

Piguel, N. H.; Sanders, S. S.; De Simone, F. I.; Martin-De- Saavedra, M. D.; Mccoig, E.; Dionisio, L. E.; Smith, K. R.; Thomas, G. M.; Penzes, P.

10.1101/620708 — neuroscience — Posted on 2023-01-12

2713 ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis

Jourdon, A.; Wu, F.; Mariani, J.; Capauto, D.; Norton, S.; Tomasini, L.; Amiri, A.; Suvakov, M.; Schreiner, J.; Jang, Y.; Panda, A.; Nguyen, C. K.; Cummings, E. M.; Han, G.; Powell, K.; Szekely, A.; McPartland, J. C.; Pelphrey, K.; Chawarska, K.; Ventola, P.; Abyzov, A.; Vaccarino, F. M.

10.1101/2022.03.19.484988 — neuroscience — Posted on 2023-01-12

2714 Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens.

Sumanth, M. S.; Liu, Y.; Wu, J.; Fechter, L.; Murugesan, K.; Maecker, H.; Gotlib, J.; Zehnder, J.; Paulmurugan, R.; Krishnan, A.

10.1101/2023.01.07.523111 — cancer biology — Posted on 2023-01-12

2715 Membrane-binding properties of NS1 proteins from Zika and Dengue viruses: Comparative simulations in explicit bilayers reveal significant differences

Muthukumaran, R.; Sankararamakrishnan, R.

10.1101/2023.01.12.523767 — biophysics — Posted on 2023-01-12

2716 The molecular mechanism of monovalent cation selectivity in the TRPM5 channel

Ives, C. M.; Thomson, N. J.; Zachariae, U.

10.1101/2023.01.11.523625 — biophysics — Posted on 2023-01-12

2717 Helical Intermediate Formation and Its Role in Amyloid of an Amphibian Antimicrobial Peptide

Prasad, A. K.; Martin, L. L.; Panwar, A. S.

10.1101/2023.01.11.523545 — biophysics — Posted on 2023-01-12

2718 Single-cell methylation sequencing data reveal succinct metastatic migration histories and tumor progression models

Liu, Y.; Li, X. C.; Rashidi Mehrabadi, F.; Schäffer, A. A.; Pratt, D.; Crawford, D. R.; Malikic, S.; Molloy, E.; Gopalan, V.; Mount, S. M.; Ruppin, E.; Aldape, K.; Sahinalp, S. C.

10.1101/2021.03.22.436475 — bioinformatics — Posted on 2023-01-12

2719 Small cell lung cancer co-culture organoids provide insights into cancer cell survival after chemotherapy

Sen, C.; Koloff, C.; Kundu, S.; Wilkinson, D. C.; Yang, J.; Shia, D. W.; Meneses, L. K.; Rickabaugh, T. M.; Gomperts, B.

10.1101/2023.01.03.522668 — bioengineering — Posted on 2023-01-12

2720 Crosslinking by ZapD drives the assembly of short, discontinuous FtsZ filaments into ring-like structures in solution

Merino-Salomon, A.; Schneider, J.; Babl, L.; Krohn, J.-H.; Sobrinos-Sanguino, M.; Schäfer, T.; Luque-Ortega, J. R.; Alfonso, C.; Jimenez, M.; Jasnin, M.; Rivas, G.; Schwille, P.

10.1101/2023.01.12.523557 — biochemistry — Posted on 2023-01-12

2721 High Throughput Single Cell Proteomic Analysis of Organ Derived Heterogeneous Cell Populations by Nanoflow Dual Trap Single Column Liquid Chromatography

Kreimer, S.; Binek, A.; Chazarin, B.; Cho, J. H.; Haghani, A.; Hutton, A.; Marban, E.; Mastali, M.; Meyer, J. G.; Ribeiro Mesquita, T. R.; Song, Y.; Van Eyk, J.; Parker, S. J.

10.1101/2023.01.06.522908 — biochemistry — Posted on 2023-01-12

2722 A hepatitis B virus (HBV) sequence variation graph improves sequence alignment and sample-specific consensus sequence construction for genetic analysis of HBV

Duchen, D. A.; Clipman, S.; Vergara, C.; Thio, C. L.; Thomas, D. L.; Duggal, P.; Wojcik, G. L.

10.1101/2023.01.11.523611 — genomics — Posted on 2023-01-12

2723 Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infection

Dwivedi, A. K.; Siegel, D. A.; Thanh, C.; Hoh, R.; Hobbs, K. S.; Pan, T.; Gibson, E. A.; Martin, J.; Hecht, F.; Pilcher, C.; Milush, J.; Busch, M. P.; Stone, M.; Huang, M.-L.; Levy, C. N.; Roychoudhury, P.; Hladik, F.; Jerome, K. R.; Henrich, T. J.; Deeks, S. G.; Lee, S. A.

10.1101/2023.01.10.523535 — genetics — Posted on 2023-01-12

2724 DNA metabarcoding using new rbcL and ITS2 metabarcodes collectively enhance detection efficiency of medicinal plants in single and polyherbal formulations

Travadi, T.; Shah, A. P.; Pandit, R.; Sharma, S.; Joshi, C.; Joshi, M.

10.1101/2023.01.11.523696 — molecular biology — Posted on 2023-01-12

2725 Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation

Höpfler, M.; Absmeier, E.; Peak-Chew, S.-Y.; Vartholomaiou, E.; Passmore, L. A.; Gasic, I.; Hegde, R. S.

10.1101/2023.01.12.523749 — molecular biology — Posted on 2023-01-12

2726 SEC-TMT facilitates quantitative differential analysis of protein interaction networks

Doron-Mandel, E.; Bokor, B. J.; Ma, Y.; Street, L. A.; Tang, L. C.; Abdou, A. A.; Shah, N. H.; Rosenberger, G.; Jovanovic, M.

10.1101/2023.01.12.523793 — molecular biology — Posted on 2023-01-12

2727 Spliceosomal mutations decouple 3' splice site fidelity from cellular fitness

Roy, K. R.; Gabunilas, J.; Neutel, D.; Ai, M.; Samson, J. A.; Lyu, G.; Chanfreau, G. F.

10.1101/2023.01.12.523824 — molecular biology — Posted on 2023-01-12

2728 BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis.

Salas-Lloret, D.; Garcia-Rodriguez, N.; Giebel, L.; de Ru, A. H.; van Veelen, P. A.; Huertas, P.; Vertegaal, A. C. O.; Gonzalez-Prieto, R.

10.1101/2023.01.12.523782 — molecular biology — Posted on 2023-01-12

2729 FOXM1 acts sexually dimorphically to regulate functional β-cell mass

Peng, G.; Mosleh, E.; Yuhas, A.; Katada, K.; Cherry, C.; Golson, M. L.

10.1101/2023.01.12.523673 — molecular biology — Posted on 2023-01-12

2730 Actin nucleators safeguard replication forks by limiting nascent strand degradation

Nieminuszczy, J.; Martin, P. R.; Broderick, R.; Krwawicz, J.; Kanellou, A.; Mocanu, C.; Smith, C.; Wen, K.-K.; Woodward, B. L.; Bakal, C.; Shackley, F.; Aguilera, A.; Stewart, G. S.; Vyas, Y. M.; Niedzwiedz, W.

10.1101/2023.01.12.523639 — molecular biology — Posted on 2023-01-12

2731 An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3-RIF1 interaction critical for DNA repair activity

Sifri, C.; Hoeg, L.; Durocher, D.; Setiaputra, D.

10.1101/2023.01.12.523815 — molecular biology — Posted on 2023-01-12

2732 Diverse methanotrophs from alpha and gammaproteobacteria dwell in a stone quarry: a study from Western India wetland

Mohite, J.; Manvi, S.; Pardhi, K.; Bahulikar, R. A.; Rahalkar, M. C.

10.1101/2023.01.11.523701 — microbiology — Posted on 2023-01-12

2733 A Single Laccase Acts as a Key Component of Environmental Sensing in a Broad Host Range Fungal Pathogen

Westrick, N. M.; Dominguez, E. G.; Hull, C. M.; Smith, D.; Kabbage, M.

10.1101/2023.01.12.523834 — microbiology — Posted on 2023-01-12

2734 Measuring prion propagation in single bacteria elucidates mechanism of loss

Jager, K.; Orozco-Hildago, M. T.; Springstein, B. L.; Joly-Smith, E.; Papazotos, F.; McDonough, E.; Fleming, E.; McCallum, G.; Hilfinger, A.; Hochschild, A.; Potvin-Trottier, L.

10.1101/2023.01.11.523042 — microbiology — Posted on 2023-01-12

2735 Uptake-independent killing of macrophages by extracellular aggregates of Mycobacterium tuberculosis is ESX-1 and PDIM-dependent

Toniolo, C.; Dhar, N.; McKinney, J. D.

10.1101/2023.01.11.523669 — microbiology — Posted on 2023-01-12

2736 Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

Dong, Q.; Lin, H.; Allen, M.-M.; Garneau, J. R.; Sia, J. K.; Smith, R. C.; Haro, F.; McMillen, T.; Pope, R. L.; Metcalfe, C.; Burgo, V.; Woodson, C.; Dylla, N.; Kohout, C.; Sundararajan, A.; Snitkin, E. S.; Young, V. B.; Fortier, L.-C.; Kamboj, M.; Pamer, E. G.

10.1101/2023.01.12.523823 — microbiology — Posted on 2023-01-12

2737 Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses

Shakri, A. R.; Wang, C.; Lucky, A. B.; Kalamuddin, M.; Chim-Ong, A.; Li, X.; Cui, L.; Miao, J.

10.1101/2023.01.11.523703 — microbiology — Posted on 2023-01-12

2738 Microbiome derived acidity protects against microbial invasion in Drosophila

Barron, A. J.; Lesperance, D. N. A.; Doucette, J.; Calle, S.; Broderick, N. A.

10.1101/2023.01.12.523836 — microbiology — Posted on 2023-01-12

2739 Phage vB_KmiS-Kmi2C infects members of the Klebsiella oxytoca complex and represents a novel genus of lytic bacteriophage

Newberry, F.; Shibu, P.; Smith-Zaitlik, T.; Eladawy, M.; McCartney, A. L.; Hoyles, L.; Negus, D.

10.1101/2023.01.12.523727 — microbiology — Posted on 2023-01-12

2740 Glycine homeostasis requires reverse SHMT flux

McBride, M. J.; Hunter, C. J.; Rabinowitz, J.

10.1101/2023.01.11.523668 — biochemistry — Posted on 2023-01-12

2741 Urinary Glycosaminoglycans are Associated with Recurrent UTI and Urobiome Ecology in Postmenopausal Women

Neugent, M. L.; Hulyalkar, N. V.; Kumar, A.; Xing, C.; Zimmern, P. E.; Shulaev, V.; De Nisco, N. J.

10.1101/2023.01.11.523678 — biochemistry — Posted on 2023-01-12

2742 Cryo-EM structure of the endothelin-1-ETB-Gi complex

Sano, F. K.; Akasaka, H.; Shihoya, W.; Nureki, O.

10.1101/2023.01.12.523720 — biochemistry — Posted on 2023-01-12

2743 Candida albicans oropharyngeal infection is an exception to iron-based nutritional immunity

Solis, N. V.; Wakade, R. S.; Filler, S.; Krysan, D. J.

10.1101/2023.01.11.523704 — microbiology — Posted on 2023-01-12

2744 Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV)

Choi, A.; Kots, E.; Singleton, D.; Weinstein, H.; Whittaker, G.

10.1101/2023.01.11.523687 — microbiology — Posted on 2023-01-12

2745 The phenotype and genotype of fermentative microbes

Hackmann, T.

10.1101/2023.01.12.523810 — microbiology — Posted on 2023-01-12

2746 Reinforcement Learning informs optimal treatmentstrategies to limit antibiotic resistance.

Weaver, D. T.; Maltas, J.; Scott, J. G.

10.1101/2023.01.12.523765 — microbiology — Posted on 2023-01-12

2747 Uncovering specific mechanisms across cell types in dynamical models

Hauber, A. L.; Rosenblatt, M.; Timmer, J.

10.1101/2023.01.10.523526 — systems biology — Posted on 2023-01-12

2748 Increased mesoscale diffusivity in response to acute glucose starvation

Xie, Y.; Gresham, D.; Holt, L. J.

10.1101/2023.01.10.523352 — biophysics — Posted on 2023-01-12

2749 Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular ciliate Stentor

Shekhar, S.; Guo, H.; Colin, S. P.; Marshall, W. F.; Kanso, E. A.; Costello, J. H.

10.1101/2023.01.10.523506 — biophysics — Posted on 2023-01-12

2750 Non-operable glioblastoma: proposition of patient-specific forecasting by image-informed poromechanical model

Urcun, S.; Baroli, D.; Rohan, P.-Y.; Skalli, W.; Lubrano, V.; Bordas, S.; Sciume, G.

10.1101/2023.01.10.523475 — biophysics — Posted on 2023-01-12

2751 nleval: A Python Toolkit for Generating Benchmarking Datasets for Machine Learning with Biological Networks

Liu, R.; Krishnan, A.

10.1101/2023.01.10.523485 — bioinformatics — Posted on 2023-01-12

2752 Chitosan oligosaccharide induces plant resistance gene expression in Pinus massoniana

Yin, H.; Guo, W.; Fang, J.; Liu, H.; Dong, G.; Li, X.

10.1101/2023.01.11.523542 — genomics — Posted on 2023-01-12

2753 Determining Best Practice for the Spatial Poisson Process in Species Distribution Modelling

Bellew, S.; Flint, I.; WANG, Y.

10.1101/2023.01.10.523499 — ecology — Posted on 2023-01-12

2754 Spatial exclusion leads to tug-of-war ecological dynamics between competing species within microchannels

Rothschild, J.; Ma, T.; Milstein, J. N.; Zilman, A.

10.1101/2023.01.10.523527 — ecology — Posted on 2023-01-12

2755 BMP suppresses WNT to integrate patterning of orthogonal body axes in adult planarians.

Clark, E. G.; Petersen, C.

10.1101/2023.01.10.523528 — developmental biology — Posted on 2023-01-12

2756 Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies

Fischer, K.; Lulla, A.; So, T.; Pereyra-Gerber, P.; Raybould, M. I. J.; Kohler, T. N.; Kaminski, T. S.; Yam-Puc, J. C.; Hughes, R.; Leiss-Maier, F.; Brear, P.; Matheson, N. J.; Deane, C.; Hyvonen, M.; Thaventhiran, J.; Hollfelder, F.

10.1101/2023.01.10.523494 — immunology — Posted on 2023-01-12

2757 Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signalingduring steatohepatitis in diet-induced NAFLD.

LOW, Z. S.; CHUA, D.; CHENG, H. S.; TEE, R.; SAHIB, W. R.; BALL, C.; SAHIB, N. B. E.; NG, S. S.; QU, J.; LIU, Y.; HONG, H.; CAI, C.; RAO, N. C. L.; WEE, A.; MUTHIAH, M. D.; BICHLER, Z.; MICKELSON, B.; LEE, J. Q.; NG, A. S.; YIP, Y. S.; VOS, M. I. G.; LIM, D. X. E.; CHITTEZHATH, M.; YALIGAR, J.; VERMA, S. K.; POPTANI, H.; GUAN, X. L.; VELAN, S. S.; ALI, Y.; LI, L.; TAN, N. S.; WAHLI, W.

10.1101/2023.01.10.523354 — immunology — Posted on 2023-01-12

2758 Noise improves the association between effects of local stimulation and structural degree of brain networks

Zheng, Y.; Tang, S.; Zheng, H.; Wang, X.; Liu, L.; Yang, Y.; Zhen, Y.; Zheng, Z.

10.1101/2023.01.10.523529 — neuroscience — Posted on 2023-01-12

2759 Femtosecond laser preparation of resin embedded samples for correlative microscopy workflows in life sciences

Bosch, C.; Lindenau, J.; Pacureanu, A.; Peddie, C. J.; Majkut, M.; Douglas, A. C.; Carzaniga, R.; Rack, A.; Collinson, L.; Schaefer, A.; Stegmann, H.

10.1101/2023.01.10.523473 — neuroscience — Posted on 2023-01-12

2760 Brain signatures indexing variation in internal processing during perceptual decision-making

Nakuci, J.; Samaha, J.; Rahnev, D.

10.1101/2023.01.10.523502 — neuroscience — Posted on 2023-01-12

2761 A Network Pharmacology Approach to Elucidate the Anti-inflammatory Effects of Ellagic Acid

Hoang, S. H.

10.1101/2023.01.10.523505 — pharmacology and toxicology — Posted on 2023-01-12

2762 Modelling drug responses and evolutionary dynamics using triple negative breast cancer patient-derived xenografts

Shea, A.; Eyal-Lubling, Y.; Guerrero-Romero, D.; Manzano Garcia, R.; Greenwood, W.; O'Reilly, M.; Georgopoulou, D.; Callari, M.; Lerda, G.; Wix, S.; Giovannetti, A.; Masina, R.; Esmaeilishirazifard, E.; Martin, A. G.; Nagano, A.; Young, L.; Kupczak, S.; Cheng, Y.; Bardwell, H.; Provenzano, E.; Kane, J.; Lay, J.; Grybowicz, L.; McAdam, K.; Caldas, C.; Abraham, J.; Rueda, O. M.; Bruna, A.

10.1101/2023.01.10.523259 — cancer biology — Posted on 2023-01-12

2763 Novel CAF-identifiers via transcriptomic analysis in oral cancer patients

Dwivedi, N.; Shukla, N.; Das, M.; Dhar, S.

10.1101/2023.01.10.523511 — cancer biology — Posted on 2023-01-12

2764 Identification of Cell-Type Specific Alternative Transcripts in the Multicellular Alga Volvox carteri

Balasubramanian, R. N.; Umen, J. G.

10.1101/2023.01.10.523483 — bioinformatics — Posted on 2023-01-12

2765 Design of 8-mer Peptides that Block Clostridioides difficile Toxin A in Intestinal Cells

Sarma, S.; Catella, C. M.; Pedro, E. T. S.; Xiao, X.; Durmusoglu, D.; Menegatti, S.; Crook, N.; Magness, S. T.; Hall, C.

10.1101/2023.01.10.523493 — bioengineering — Posted on 2023-01-12

2766 Perilaryngeal Functional Muscle Network in Patients with Vocal Hyperfunction - A Case Study

O'Keeffe, R.; Shirazi, Y.; Mehrdad, S.; Crosby, T.; Johnson, A. M.; Atashzar, S. F.

10.1101/2023.01.10.523514 — bioengineering — Posted on 2023-01-12

2767 Near-chromosome level genome assembly of devil firefish, Pterois miles

Kitsoulis, C. V.; Papadogiannis, V.; Kristoffersen, J. B.; Kaitetzidou, E.; Sterioti, A.; Tsigenopoulos, C. S.; Manousaki, T.

10.1101/2023.01.10.523469 — genomics — Posted on 2023-01-12

2768 MRBEE: A novel bias-corrected multivariable Mendelian Randomization method

Lorincz-Comi, N. J.; Yang, Y.; Li, G.; Zhu, X.

10.1101/2023.01.10.523480 — genomics — Posted on 2023-01-12

2769 Multiomic identification of key transcriptional regulatory programs during endurance exercise training

Smith, G. R.; Zhao, B.; Lindholm, M. E.; Raja, A.; Viggars, M. R.; Pincas, H.; Gay, N. R.; Sun, Y.; Ge, Y.; Nair, V. D.; Sanford, J. A.; Amper, M. A. S.; Vasoya, M.; Smith, K. S.; Montgomery, S. B.; Zaslavsky, E.; Bodine, S. C.; Esser, K. A.; Walsh, M. J.; Snyder, M.; Sealfon, S. C.

10.1101/2023.01.10.523450 — genomics — Posted on 2023-01-12

2770 Improving the predictive performance of CLUE-S by extending demand to land transitions: the trans-CLUE-S model

Kiziridis, D. A.; Mastrogianni, A.; Pleniou, M.; Tsiftsis, S.; Xystrakis, F.; Tsiripidis, I.

10.1101/2023.01.10.523486 — ecology — Posted on 2023-01-12

2771 Wnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea.

Russell, N.; Burra, K.; Shah, R.; Bottasso-Arias, N.; Mohanakrishnan, M.; Snowball, J.; Ediga, H.; Madala, S. K.; Sinner, D. I.

10.1101/2023.01.10.523309 — developmental biology — Posted on 2023-01-12

2772 Change in brain asymmetry reflects level of acute alcohol intoxication and impacts on inhibitory control

Dubois, J.; Field, R. M.; Jawhar, S.; Jewison, A.; Koch, E. M.; M. Aghajan, Z.; Miller, N.; Perdue, K. L.; Taylor, M.

10.1101/2023.01.10.523048 — neuroscience — Posted on 2023-01-12

2773 Production of β-PheRS fragments correlates with food avoidance and slow growth, and is suppressed by the appetite-inducing hormone CCHa2

Brunssen, D.; Suter, B.

10.1101/2023.01.11.523627 — developmental biology — Posted on 2023-01-12

2774 Leftward transfer of a chemosensory polycystin initiates left-dominant calcium signaling for lateralized embryonic development

Tanaka, Y.; Morozumi, A.; Hirokawa, N.

10.1101/2023.01.12.523739 — developmental biology — Posted on 2023-01-12

2775 Trophoblast organoids with physiological polarity model placental structure and function

Yang, L.; Liang, P.; Yang, H.; Coyne, C.

10.1101/2023.01.12.523752 — cell biology — Posted on 2023-01-12

2776 The psychosis risk factor RBM12 encodes a novel repressor of GPCR/cAMP signal transduction

Semesta, K. M.; Garces, A.; Tsvetanova, N. G.

10.1101/2023.01.12.523776 — cell biology — Posted on 2023-01-12

2777 Independent regulation of Z-lines and M-linesduring sarcomere assembly in cardiac myocytesrevealed by the automatic image analysis software sarcApp

Neininger-Castro, A. C.; Hayes, J. B.; Sanchez, Z. C.; Taneja, N.; Fenix, A. M.; Moparthi, S.; Vassilopoulos, S.; Burnette, D. T.

10.1101/2023.01.11.523681 — cell biology — Posted on 2023-01-12

2778 Engraftment of wild-type alveolar type II epithelial cells in surfactant protein C deficient mice

Iezza, D.; Predella, C.; NI, K.; Murray, J. W.; Liu, H.-Y.; Saqi, A.; Glasser, S. W.; Dorrello, N. V.

10.1101/2023.01.12.523571 — cell biology — Posted on 2023-01-12

2779 Oncogenic Ras deregulates cell-substrate interactions during mitotic rounding and respreading to alter cell division orientation

Ganguli, S.; Wyatt, T.; Meyer, T.; Baum, B.; Matthews, H.

10.1101/2023.01.12.523730 — cell biology — Posted on 2023-01-12

2780 Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile

Carrera-Bravo, C.; Zhou, T.; Hang, J. W.; Modh, H.; Huang, F.; Malleret, B.; Wacker, M. G.; Wang, J.-W.; Renia, L.; Tan, K. S.

10.1101/2023.01.11.523595 — cell biology — Posted on 2023-01-12

2781 End Binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of Dense Core Vesicles

Park, J.; Miller, K. G.; De Camilli, P.; Yogev, S.

10.1101/2023.01.12.523768 — cell biology — Posted on 2023-01-12

2782 MARCH5-dependent NLRP3 ubiquitination is an essential step for NEK7 docking on the mitochondria

Park, Y.-J.; Dodantenna, N.; Kim, T.-H.; Lee, H.-S.; Yoo, Y.-S.; Lee, E.-S.; Lee, J.-H.; Kwon, M.-H.; Kang, H. C.; Lee, J.-S.; Cho, H.

10.1101/2023.01.12.523764 — immunology — Posted on 2023-01-12

2783 Transcriptional signatures of heroin intake and seeking throughout the brain reward circuit

Browne, C. J.; Futamura, R.; Minier-Toribio, A.; Hicks, E. M.; Ramakrishnan, A.; Martinez-Rivera, F.; Estill, M.; Godino, A.; Parise, E. M.; Torres-Berrio, A.; Cunningham, A. M.; Hamilton, P. J.; Walker, D. M.; Huckins, L. M.; Hurd, Y. L.; Shen, L.; Nestler, E. J.

10.1101/2023.01.11.523688 — neuroscience — Posted on 2023-01-12

2784 Not all Notch pathway mutations are equal in the embryonic mouse retina

Bosze, B.; Suarez-Navarro, J.; Cajias, I.; Brzezinski, J. A.; Brown, N. L.

10.1101/2023.01.11.523641 — developmental biology — Posted on 2023-01-12

2785 Maternal exposure to environmental levels of carbamazepine induces mild growth retardation in mouse embryos

Douek-Maba, O.; Kalev-Altman, R.; Mordehay, V.; Hayby-Averbuch, H.; Shlezinger, N.; Chefetz, B.; Sela-Donenfeld, D.

10.1101/2023.01.12.523650 — developmental biology — Posted on 2023-01-12

2786 DNA elements tether canonical Polycomb Repressive Complex 1 to human genes

Barrasa, J. I.; Kahn, T. G.; Lundkvist, M. J.; Schwartz, Y. B.

10.1101/2023.01.12.523763 — developmental biology — Posted on 2023-01-12

2787 Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase

Batty, P.; Langer, C. C. H.; Takacs, Z.; Tang, W.; Blaukopf, C.; Peters, J.-M.; Gerlich, D. W.

10.1101/2023.01.12.523718 — cell biology — Posted on 2023-01-12

2788 Senescent cells deposit intracellular contents through adhesion-dependent fragmentation

Durik, M.; Sampaio Goncalves, D.; Spiegelhalter, C.; Messaddeq, N.; Keyes, B.

10.1101/2023.01.11.523642 — cell biology — Posted on 2023-01-12

2789 Insulin determines the effects of TGF-beta on HNF4alpha transcription and epithelial-to-mesenchymal transition in hepatocytes

10.1101/2023.01.12.523351 — cell biology — Posted on 2023-01-12

2790 MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy

Kim, Y.; Li, C.; Gu, C.; Tycksen, E.; Puri, A.; Pietka, T. A.; Sivapackiam, J.; Fang, Y.; Kidd, K.; Park, S.-J.; Johnson, B. G.; Kmoch, S.; Duffield, J. S.; Bleyer, A. J.; Jackrel, M. E.; Urano, F.; Vijay, s.; Lindahl, M.; Chen, Y. M.

10.1101/2023.01.10.523171 — cell biology — Posted on 2023-01-12

2791 Mitotic events depend on regulation of PLK-1 levels by the mitochondrial protein SPD-3

Redemann, S.; Chen, Y.-Z.; Zimyanin, V. L.

10.1101/2023.01.11.523633 — cell biology — Posted on 2023-01-12

2792 The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2 in vitro

Chen, H.-F.; Wang, W.-J.; Chen, C.-Y.; Chang, W.-C.; Hsueh, P.-R.; Peng, S.-L.; Wu, C.-S.; Chen, Y.; Huang, H.-Y.; Shen, W.-J.; Wang, S.-C.; Hung, M.-C.

10.1101/2023.01.12.523465 — microbiology — Posted on 2023-01-12

2793 Vectored Immunoprophylaxis and Treatment of SARS-CoV-2 Infection

Tada, T.; Dcosta, B. M.; Minnee, J.; Landau, N. R.

10.1101/2023.01.11.523649 — microbiology — Posted on 2023-01-12

2794 Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection

Vaca, G. B.; Meyer, M.; Cadete, A.; Hsiao, C. J.; Golding, A.; Jeon, A.; Jacquinet, E.; Azcue, E.; Guan, C. M.; Sanchez-Felix, X.; Pietzsch, C. A.; Mire, C. E.; Hyde, M. A.; Comeaux, M. E.; Williams, J. M.; Sung, J. C.; Carfi, A.; Edwards, D. K.; Bukreyev, A.; Bahl, K.

10.1101/2023.01.11.523616 — immunology — Posted on 2023-01-12

2795 Transfer learning identifies sequence determinants of regulatory element accessibility

Salvatore, M.; Horlacher, M.; Marsico, A.; Winther, O.; Andersson, R.

10.1101/2022.08.05.502903 — bioinformatics — Posted on 2023-01-12

2796 CHC22 clathrin membrane recruitment uses SNX5 in bipartite interaction with secretory tether p115

Greig, J.; Bates, G. T.; Yin, D. I.; Simonetti, B.; Cullen, P. J.; Brodsky, F. M.

10.1101/2022.12.21.520923 — cell biology — Posted on 2023-01-12

2797 Acute adenoviral cardiac infection elicits an arrhythmogenic substrate prior to inflammatory myocardial remodeling and myocarditis

Padget, R. L.; Blair, G. A.; North, M. D.; Zeitz, M. J.; Tanenbaum, M. T.; King, D. R.; Hoeker, G. S.; Swanger, S. A.; Poelzing, S.; Smyth, J. W.

10.1101/2022.11.29.518421 — pathology — Posted on 2023-01-12

2798 Running ahead of evolution - AI based simulation for predicting future high-risk SARS-CoV-2 variants

Chen, J.; Nie, Z.; Wang, Y.; Wang, K.; Xu, F.; Hu, Z.; Zheng, B.; Wang, Z.; Song, G.; Zhang, J.; Fu, J.; Huang, X.; Wang, Z.; Ren, Z.; Wang, Q.; Li, D.; Wei, D.; Zhou, B.; Yang, C.; Tian, Y.; Gao, W.

10.1101/2022.11.17.516989 — bioinformatics — Posted on 2023-01-12

2799 A local translation program regulates centriole amplification in the airway epithelium

Liu, H.; Li, H.; Jiang, Z.; Jin, S.; Song, R.; Yang, Y.; Li, J.; Huang, J.; Zhang, X.; Dong, X.; Mori, M.; Fritzler, M. J.; He, L.; Cardoso, W. V.; Lu, J.

10.1101/2022.01.18.476821 — cell biology — Posted on 2023-01-12

2800 Prophylaxis and Treatment of SARS-CoV-2 infection by an ACE2 Receptor Decoy

Tada, T.; Dcosta, B. M.; Zhou, H.; Landau, N. R.

10.1101/2022.12.31.522401 — microbiology — Posted on 2023-01-12

2801 Stepwise molecular specification of excitatory synapse diversity on a target neuron

Paul, M. A.; Sigoillot, S. M.; Marti, L.; Delagrange, M.; Mailly, P.; Selimi, F.

10.1101/2023.01.03.521946 — neuroscience — Posted on 2023-01-12

2802 Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

Zhang, S.; Yuan, L.; Danilova, L.; Mo, G.; Zhu, Q.; Deshpande, A.; Bell, A. T. F.; Elisseeff, J.; Popel, A. S.; Anders, R. A.; Jaffee, E. M.; Yarchoan, M.; Fertig, E. J.; Kagohara, L. T.

10.1101/2023.01.10.523481 — cancer biology — Posted on 2023-01-12

2803 Aggregation Tool for Genomic Concepts (ATGC): A deep learning framework for sparse genomic measures and its application to somatic mutations

Anaya, J.; Sidhom, J.-W.; Cummings, C. A.; Mahmood, F.; Baras, A. S.; The AACR Project GENIE Consortium,

10.1101/2020.08.05.237206 — bioinformatics — Posted on 2023-01-12

2804 Genetic diversity of North American popcorn germplasm and the effect of population structure on nicosulfuron response

Sullivan, M.; Williams, M. M.; Studer, A. J.

10.1101/2023.01.06.523022 — genetics — Posted on 2023-01-12

2805 Gallocin A, an atypical two-peptide bacteriocin with intramolecular disulfide bonds required for activity

Proutiere, A.; du Merle, L.; Garcia-Lopez, M.; Leger, C.; Voegele, A.; Chenal, A.; Harrington, A.; Tal-Gan, Y.; Cokelaer, T.; Trieu-Cuot, P.; Dramsi, S.

10.1101/2022.12.05.519244 — microbiology — Posted on 2023-01-12

2806 Drivers of genomic landscapes of differentiation across Populus divergence gradient

Shang, H.; Rendon-Anaya, M.; Paun, O.; Field, D. L.; Hess, J.; Vogl, C.; Liu, J.; Ingvarsson, P. K.; Lexer, C.; Leroy, T.

10.1101/2021.08.26.457771 — evolutionary biology — Posted on 2023-01-12

2807 Variance (un)explained: Experimental conditions and temporal dependencies explain similarly small proportions of reaction time variability in perceptual and cognitive tasks

Perquin, M. N.; Heed, T.; Kayser, C.

10.1101/2022.12.22.521656 — neuroscience — Posted on 2023-01-12

2808 Online abstraction during statistical learning revealed by neural entrainment from intracranial recordings

Sherman, B. E.; Aljishi, A.; Graves, K. N.; Quraishi, I. H.; Sivaraju, A.; Damisah, E. C.; Turk-Browne, N. B.

10.1101/2023.01.11.523605 — neuroscience — Posted on 2023-01-12

2809 SCN1A-deficient hiPSC-derived excitatory neuronal networks display mutation-specific phenotypes

van Hugte, E. J. H.; Lewerissa, E.; Wu, K. M.; Parodi, G.; van Voorst, T.; Kogo, N.; Keller, J.; Schubert, D.; Schelhaas, H. J.; Verhoeven, J.; Majoie, M.; van Bokhoven, H.; Nadif Kasri, N.

10.1101/2023.01.11.523598 — neuroscience — Posted on 2023-01-12

2810 Dysregulated gene expression through TP53 promoter swapping in osteosarcoma

Saba, K. H.; Difilippo, V.; Kovac, M.; Cornmark, L.; Magnusson, L.; Nilsson, J.; van den Bos, H. H.; Spierings, D. C. J.; Bidgoli, M.; Jonson, T.; Sumathi, V. P.; Brosjo, O.; Staaf, J.; Foijer, F.; Styring, E.; Nathrath, M.; Baumhoer, D.; Nord, K. H.

10.1101/2020.04.20.050252 — cancer biology — Posted on 2023-01-12

2811 Evolutionary dynamics of genome size and content during the adaptive radiation of Heliconiini butterflies

Cicconardi, F.; Milanetti, E.; Pinheiro de Castro, E. C.; Mazo-Vargas, A.; Belleghem, S. M.; Ruggieri, A. A.; Rastas, P.; Hanly, J. J.; Evans, E.; Jiggins, C. D.; McMillan, W. O.; Papa, R.; di Marino, D.; Martin, A.; Montgomery, S. H.

10.1101/2022.08.12.503723 — evolutionary biology — Posted on 2023-01-12

2812 Deucravacitinib, a tyrosine kinase 2 pseudokinase inhibitor, protects human beta cells against proinflammatory insults

Dos Santos, R. S.; Guzman-Llorens, D.; Perez-Serna, A. A.; Nadal, A.; Marroqui, L.

10.1101/2022.12.27.522037 — cell biology — Posted on 2023-01-12

2813 Polyethylene glycol (PEG)-associated immunological effects triggered by clinically relevant lipid nanoparticles

Wang, H.; Wang, Y.; Yuan, C.; Xu, X.; Zhou, W.; Huang, Y.; Lu, H.; Zheng, Y.; Luo, G.; Shang, J.; Sui, M.

10.1101/2022.11.24.516986 — immunology — Posted on 2023-01-12

2814 Does prefrontal connectivity during task switching help or hinder children's performance?

Schwarze, S. A.; Laube, C.; Khosravani, N.; Lindenberger, U.; Bunge, S. A.; Fandakova, Y.

10.1101/2022.10.04.510761 — neuroscience — Posted on 2023-01-12

2815 Deucravacitinib, a tyrosine kinase 2 pseudokinase inhibitor, protects human beta cells against proinflammatory insults

Dos Santos, R. S.; Guzman-Llorens, D.; Perez-Serna, A. A.; Nadal, A.; Marroqui, L.

10.1101/2022.12.27.522037 — cell biology — Posted on 2023-01-12

2816 Refinement of AlphaFold-Multimer structures with single sequence input

Oda, T.

10.1101/2022.12.27.521991 — bioinformatics — Posted on 2023-01-12

2817 Non-random interactions within and across guilds shape the potential to coexist in multi-trophic ecological communities

Garcia-Callejas, D.; Godoy, O.; Buche, L.; Hurtado, M.; B. Lanuza, J.; Allen-Perkins, A.; Bartomeus, I.

10.1101/2021.11.29.470335 — ecology — Posted on 2023-01-12

2818 Small non-coding vault RNA1-2 modulate expression of cell membrane proteins through nascent RNA silencing

Alagia, A.; Terenova, J.; Ketley, R. F.; Di Fazio, A.; Chelysheva, I.; Gullerova, M.

10.1101/2022.08.12.503724 — molecular biology — Posted on 2023-01-12

2819 Experimental Diets Dictate the Metabolic Benefits of Probiotics in Obesity

Larsen, I. S.; Choi, B. S.- Y.; Foh, B.; Kristensen, N. N.; Ouellette, A.; Haller, R. F.; Olsen, P. B.; Saulnier, D.; Sina, C.; Jensen, B. A. H.; Marette, A.

10.1101/2022.10.27.514016 — microbiology — Posted on 2023-01-12

2820 Response inhibition in Premotor cortex corresponds1to a complex reshuffle of the mesoscopic informationnetwork

Bardella, G.; Giarrocco, F.; Giuffrida, V.; Brunamonti, E.; Pani, P.; Ferraina, S.

10.1101/2021.03.15.435381 — neuroscience — Posted on 2023-01-12

2821 Exogenous chromosomes reveal how sequence composition drives chromatin assembly, activity, folding and compartmentalization

Chapard, C.; Meneu, L.; Serizay, J.; Routhier, E.; Ruault, M.; Bignaud, A.; Gourgues, G.; Lartigue, C.; Piazza, A.; Taddei, A.; Beckouet, F.; Mozziconacci, J.; Koszul, R.

10.1101/2022.12.21.520625 — genetics — Posted on 2023-01-12

2822 High quality de novo genome assembly of non-conventional yeast Kazachstania bulderi a new potential low pH production host for biorefineries.

Balarezo-Cisneros, L. N.; Timouma, S.; Hanak, A.; Currin, A.; Valle, F.; Delneri, D.

10.1101/2023.01.11.523663 — genomics — Posted on 2023-01-12

2823 Evolutionary trajectories are contingent on mitonuclear interactions

Biot-Pelletier, D.; Bettinazzi, S.; Gagnon-Arsenault, I.; Dube, A. K.; Bedard, C.; Nguyen, T. H. M.; Fiumera, H.; Breton, S.; Landry, C.

10.1101/2022.09.11.507487 — evolutionary biology — Posted on 2023-01-12

2824 X-Chromosome Target Specificity Diverged Between Dosage Compensation Mechanisms of Two Closely Related Caenorhabditis Species

Yang, Q.; Lo, T.-W.; Brejc, K.; Schartner, C.; Ralston, E. J.; Lapidus, D. M.; Meyer, B. J.

10.1101/2022.12.05.519163 — cell biology — Posted on 2023-01-12

2825 An Iron-Calcium-Miro Axis Influences Parkinson Risk and Neurodegeneration

Bharat, V.; Vanhauwaert, R.; Li, L.; Muir, C. M.; Durairaj, A. S.; Chandra, S.; Le Guen, Y.; Nandakishore, P.; Hsieh, C.-H.; Rensi, S. E.; Altman, R.; Greicius, M. D.; Feng, L.; Wang, X.

10.1101/2022.10.30.513580 — cell biology — Posted on 2023-01-12

2826 New insight into the Germline Genes and CDR3 Repertoire of the TCR-beta chain in Chiroptera

Zhou, H.; Yao, X. S.; Li, J.; Ma, Q. Q.; Liu, L. Y.; Zhou, D. W.; Wu, Y. J.; Wang, X. L.; Zhou, J.; Ma, L.

10.1101/2022.12.05.519110 — immunology — Posted on 2023-01-12

2827 Ca2+ and cAMP open differentially dilating synaptic fusion pores

Bulgari, D.; Cavolo, S. L.; Schmidt, B. F.; Buchan, K.; Bruchez, M. P.; Deitcher, D. L.; Levitan, E.

10.1101/2022.12.24.521856 — neuroscience — Posted on 2023-01-12

2828 Bulk and Mosaic Deletions of Egfr Reveal Regionally Defined Gliogenesis in the Developing Mouse Forebrain

Zhang, X.; Xiao, G.; Johnson, C. A.; Cai, Y.; Horowitz, Z.; Mennicke, C.; Coffey, R.; Haider, M.; Threadgill, D. W.; Eliscu, R.; Oldham, M. C.; Greenbaum, A. C.; Ghashghaei, H. T.

10.1101/2022.12.10.519926 — neuroscience — Posted on 2023-01-12

2829 Fragment Linker Prediction Using Deep Encoder-Decoder Network for PROTAC Drug Design

Kao, C.-T.; Lin, C.-T.; Chao, C.-L.; Lin, C.-C.

10.1101/2022.11.17.516992 — pharmacology and toxicology — Posted on 2023-01-12

2830 Centromere-associated retroelement evolution in Drosophila melanogaster reveals an underlying conflict

Hemmer, L. W.; Negm, S.; Geng, X.; Courret, C.; Navarro-Dominguez, B.; Speece, I.; Wei, X.; Altidor, E.; Chaffer, J.; Sproul, J. S.; Larracuente, A. M.

10.1101/2022.11.25.518008 — genomics — Posted on 2023-01-11

2831 A gene-level test for directional selection on gene expression

Colbran, L. L.; Ramos-Almodovar, F. C.; Mathieson, I.

10.1101/2022.11.03.515083 — genomics — Posted on 2023-01-11

2832 MetaTiME: Meta-components of the Tumor Immune Microenvironment

Zhang, Y.; Xiang, G.; Jiang, A. Y.; Lynch, A.; Zeng, Z.; Wang, C.; Zhang, W.; Fan, J.; Kang, J.; Gu, S.; Wan, C.; Zhang, B.; Liu, X. S.; Brown, M.; Meyer, C. A.

10.1101/2022.08.05.502989 — genomics — Posted on 2023-01-12

2833 Conceptual and analytical approaches for modeling the developmental origins of inequality

Malani, A.; Archie, E.; Rosenbaum, S.

10.1101/2022.02.10.479998 — evolutionary biology — Posted on 2023-01-11

2834 An epigenetic basis of adaptive plasticity in Drosophila melanogaster

DiVito-Evans, A. M.; Fairbanks, R. A.; Schmidt, P.; Levine, M. T.

10.1101/2022.10.11.511590 — evolutionary biology — Posted on 2023-01-12

2835 Multiscale modelling of invasive species control: the cane toad in Australia

Pham, A. D.; Baker, C. M.; Geard, N.

10.1101/2022.12.07.518288 — ecology — Posted on 2023-01-12

2836 Do Newly Born Orphan Proteins Resemble Never Born Proteins? A Study Using Three Deep Learning Algorithms

Liu, J.; Yuan, R.; Shao, W.; Wang, J.; Silman, I.; Sussman, J. L.

10.1101/2022.08.02.502493 — molecular biology — Posted on 2023-01-11

2837 Metagenomic Data Reveal Type I Polyketide Synthase Distributions Across Biomes

Singh, H. W.; Creamer, K. E.; Chase, A. B.; Klau, L. J.; Podell, S.; Jensen, P. R.

10.1101/2023.01.09.523365 — microbiology — Posted on 2023-01-11

2838 Defining protein variant functions using high-complexity mutagenesis libraries and enhanced mutant detection software ASMv1.0

Yang, X.; Hong, A. L.; Sharpe, T.; Giacomelli, A. O.; Lintner, R. E.; Alan, D.; Green, T.; Hayes, T. K.; Piccioni, F.; Fritchman, B.; Kawabe, H.; Sawyer, E.; Sprenkle, L.; Lee, B. P.; Persky, N. S.; Brown, A.; Greulich, H.; Aguirre, A. J.; Meyerson, M.; Hahn, W. C.; Johannessen, C. M.; Root, D. E.

10.1101/2021.06.16.448102 — systems biology — Posted on 2023-01-11

2839 Systematic integration of protein affecting mutations, gene fusions, and copy number alterations into a comprehensive somatic mutational profile

Striker, S. S.; Wilferd, S. F.; Lewis, E. M.; O'Connor, S. A.; Plaisier, C. L.

10.1101/2022.07.22.501139 — systems biology — Posted on 2023-01-11

2840 ADOPT: intrinsic protein disorder prediction through deep bidirectional transformers

Tamiola, K.; Fisicaro, C.; Dutton, O.; Hoffmann, F.; Henderson, L.; Owens, B. M. J.; Heberling, M.; Redl, I.; Paci, E.

10.1101/2022.05.25.493416 — bioinformatics — Posted on 2023-01-11

2841 Spectrum preserving tilings enable sparse and modular reference indexing

Fan, J.; Khan, J.; Pibiri, G. E.; Patro, R.

10.1101/2022.10.27.513881 — bioinformatics — Posted on 2023-01-11

2842 Bottlenose dolphins' broadband clicks are structured for communication

Stepanov, A.; Zhivomirov, H.; Nedelchev, I.; Stateva, P.

10.1101/2023.01.11.523588 — animal behavior and cognition — Posted on 2023-01-11

2843 Novel insights into the cold resistance of Hevea brasiliensis through coexpression networks

Silva, C. C.; Bajay, S. K.; Aono, A. H.; Francisco, F. R.; Junior, R. B.; de Souza, A. P.; Mantello, C. C.; Vicentini dos Santos, R.

10.1101/2021.11.02.466997 — genomics — Posted on 2023-01-11

2844 NAK associated protein 1/NAP1 is required for mitosis and cytokinesis by activating TBK1

Paul, S.; Sarraf, S.; Nam, K. H.; Zavar, L.; Biswas, S. R.; Fritsch, L. E.; DeFoor, N.; Yaron, T. M.; Johnson, J. L.; Huntsman, E. M.; Cantley, L. C.; Ordureau, A.; Pickrell, A. M.

10.1101/2022.03.09.483647 — cell biology — Posted on 2023-01-11

2845 Single-cell response to Wnt activation in human embryonic stem cells reveals uncoupling of Wnt target gene expression

Soderholm, S.; Jauregi-Miguel, A.; Pagella, P.; Ghezzi, V.; Zambanini, G.; Nordin, A.; Cantu, C.

10.1101/2023.01.11.523587 — developmental biology — Posted on 2023-01-11

2846 Neuronal activity-driven O-GlcNAcylation promotes mitochondrial plasticity

Yu, S. B.; Sanchez, R. G.; Papich, Z. D.; Whisenant, T. C.; Ghassemian, M.; Koberstein, J. N.; Stewart, M. L.; Pekkurnaz, G.

10.1101/2023.01.11.523512 — neuroscience — Posted on 2023-01-11

2847 A human stomach cell type transcriptome atlas

Öling, S.; Struck, E.; Norreen-Thorsen, M.; Zwahlen, M.; von Feilitzen, K.; Odeberg, J.; Ponten, F.; Lindskog, C.; Uhlen, M.; Dusart, P.; Butler, L.

10.1101/2023.01.10.520700 — systems biology — Posted on 2023-01-11

2848 Phage DNA polymerase prevents on-target damage and enhances precision of CRISPR editing

Yang, Q.; Abebe, J. S.; Mai, M.; Rudy, G.; Devinsky, O.; Long, C.

10.1101/2023.01.10.523496 — bioengineering — Posted on 2023-01-11

2849 Faecal glucocorticoid metabolite levels of intensive captive, free-range captive, and wild Tasmanian devils

Florent, S. N.; Clarke, J.; Bashaw, M. J.; Hamede, R. K.; Jones, M. E.; Cameron, E. Z.

10.1101/2023.01.11.523346 — zoology — Posted on 2023-01-11

2850 Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infection

10.1101/2023.01.10.523535 — genetics — Posted on 2023-01-11

2851 Natural selection differences detected in key protein domains between non-pathogenic and pathogenic Feline Coronavirus phenotypes

Zehr, J. D.; Kosakovsky Pond, S. L.; Millet, J. K.; Olarte-Castillo, X. A.; Lucaci, A. G.; D, S. S.; Ceres, K.; Choi, A.; Whittaker, G.; Goodman, L. B.; Stanhope, M. J.

10.1101/2023.01.11.523607 — evolutionary biology — Posted on 2023-01-11

2852 Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes

Ma, L.; Singh, J.; Schekman, R.

10.1101/2023.01.11.523558 — cell biology — Posted on 2023-01-11

2853 Retroviral infection and commensal bacteria dependently alter the metabolomic profile in a sterile organ

Spring, J.; Beilinson, V.; DeFelice, B. C.; Sanchez, J. M.; Fischbach, M.; Chervonsky, A.; Golovkina, T.

10.1101/2023.01.10.523497 — microbiology — Posted on 2023-01-11

2854 Bacterial meningitis in the early postnatal mouse studied at single-cell resolution

Wang, J.; Rattner, A.; Nathans, J.

10.1101/2023.01.11.523597 — immunology — Posted on 2023-01-11

2855 Accelerated evolution using the phage T7 and its application to evolve riboswitches

Goicoechea, E.; Jaramillo, A.

10.1101/2023.01.11.523572 — synthetic biology — Posted on 2023-01-11

2856 A role for the proteasome alpha2 subunit N-tail in substrate processing

Sahu, I.; Bajorek, M.; Xiaolin, T.; Srividya, M.; Krutauz, D.; Reis, N.; Osmulski, P. A.; Gaczynska, M. E.; Glickman, M. H.

10.1101/2023.01.11.523624 — biochemistry — Posted on 2023-01-11

2857 Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation

Laroussi, H.; Juarez-Martinez, A. B.; Le Roy, A.; Boeri Erba, E.; de Massy, B.; Kadlec, J.

10.1101/2023.01.11.523614 — biochemistry — Posted on 2023-01-11

2858 Structure and activity of botulinum neurotoxin X

Martinez-Carranza, M.; Skerlova, J.; Lee, P.-G.; Zhang, J.; Burgin, D.; Elliott, M.; Philippe, J.; Donald, S.; Hornby, F.; Henriksson, L.; Masuyer, G.; Beard, M.; Dong, M.; Stenmark, P.

10.1101/2023.01.11.523524 — biochemistry — Posted on 2023-01-11

2859 Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor

Noddings, C. M.; Johnson, J. L.; Agard, D. A.

10.1101/2023.01.10.523504 — biochemistry — Posted on 2023-01-11

2860 Dynamic DNA methylation turnover at the exit of pluripotency epigenetically primes gene regulatory elements for hematopoietic lineage specification

Parry, A. J.; Krueger, C.; Lohoff, T.; Wingett, S.; Schoenfelder, S.; Reik, W.

10.1101/2023.01.11.523441 — molecular biology — Posted on 2023-01-11

2861 Defective transfer of parental histone decreases frequency of homologous recombination in budding yeast

Karri, S.; Yang, Y.; Zhou, J.; Dickson, Q.; Wang, Z.; gan, h.; Yu, C.

10.1101/2023.01.10.523501 — molecular biology — Posted on 2023-01-11

2862 Improved enzymatic labeling of fluorescent in situ hybridization probes applied to the visualization of retained introns in cells

Xiao, W.; Yeom, K.-H.; Lin, C.-H.; Black, D. L.

10.1101/2023.01.10.523484 — molecular biology — Posted on 2023-01-11

2863 Branched multimeric peptides as affinity reagents for detection of α-Klotho protein

Ye, X.; Zhang, P.; Wang, J. C. K.; Smith, C. L.; Sousa, S.; Loas, A.; Eaton, D. L.; Preciado Lopez, M.; Pentelute, B. L.

10.1101/2023.01.10.523487 — molecular biology — Posted on 2023-01-11

2864 Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization

Schwalm, M. P.; Kraemer, A.; Doelle, A.; Weckesser, J.; Yu, X.; Jin, J.; Saxena, K.; Knapp, S.

10.1101/2023.01.11.523589 — molecular biology — Posted on 2023-01-11

2865 Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity

Broderick, R.; Cherdyntseva, V.; Nieminuszczy, J.; Dragona, E.; Kyriakaki, M.; Evmorfopoulou, T.; Gagos, S.; Niedzwiedz, W.

10.1101/2023.01.11.523580 — molecular biology — Posted on 2023-01-11

2866 Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

Chan, A. W.; Broncel, M.; Haseley, N. R.; Chakladar, S.; Andree, E.; Herneisen, A. L.; Shortt, E.; Treeck, M.; Lourido, S.

10.1101/2023.01.11.523553 — microbiology — Posted on 2023-01-11

2867 The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS

Hurst, M. N.; Beebout, C. J.; Hollingsworth, A.; Guckes, K. R.; Purcell, A. B.; Bermudez, T.; Williams, D.; Trent, M. S.; Hadjifrangiskou, M.

10.1101/2023.01.10.523522 — microbiology — Posted on 2023-01-11

2868 Next-generation diarylquinolines improve sterilizing activity of regimens with pretomanid and the novel oxazolidinone TBI-223 in a mouse tuberculosis model

Li, S.-Y.; Converse, P. J.; Betoudji, F.; Lee, J.; Mdluli, K.; Upton, A.; Fotouhi, N.; Nuermberger, E.

10.1101/2023.01.10.523519 — microbiology — Posted on 2023-01-11

2869 Ethanolaminephosphate cytidyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major

Basu, S.; Pawlowic, M.; Hsu, F.-F.; Thomas, G.; Zhang, K.

10.1101/2023.01.10.523530 — microbiology — Posted on 2023-01-11

2870 Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance

Rodrigues, M.; Sabaeifard, P.; Yildiz, M. S.; Coughlin, L.; Ahmed, S.; Behrendt, C.; Wang, X.; Monogue, M.; Kim, J.; Gan, S.; Zhan, X.; Filkins, L.; Williams, N.; Hooper, L.; Koh, A.; Toprak, E.

10.1101/2023.01.11.523617 — microbiology — Posted on 2023-01-11

2871 Exosome based multivalent vaccine: achieving potent immunization, broaden reactivity and T cell response with nanograms of proteins without any adjuvant.

Cacciottolo, M.; Nice, J. B.; Li, Y.; LeClaire, M. J.; Twaddle, R.; Mora, C. L.; Adachi, S. Y.; Chin, E. R.; Young, M.; Angeles, J.; Elliott, K.; Sun, M.

10.1101/2023.01.10.523356 — immunology — Posted on 2023-01-11

2872 Indirect enrichment of desirable, but less fit phenotypes, from a synthetic microbial community using microdroplet confinement

Prabhakar, R. G.; Fan, G.; Alnahhas, R. N.; Hirning, A. J.; Bennett, M. R.; Shamoo, Y.

10.1101/2023.01.11.523444 — synthetic biology — Posted on 2023-01-11

2873 Steady-state polypeptide transfer from the translocon to the membrane

Knyazev, D. G.; Schaur, M.; Kuttner, R.; Siligan, C.; Goessweiner-Mohr, N.; Hagleitner-Ertugrul, N.; Pohl, P.

10.1101/2023.01.10.523415 — biophysics — Posted on 2023-01-11

2874 ODNA: Identification of Organellar DNA by Machine Learning

Martin, R.; Nguyen, M. K.; Lowack, N.; Heider, D.

10.1101/2023.01.10.523051 — bioinformatics — Posted on 2023-01-11

2875 A chromosome-scale assembly for tetraploid sour cherry (Prunus cerasus L.) 'Montmorency' identifies three distinct ancestral Prunus genomes

Goeckeritz, C. Z.; Rhoades, K. E.; Childs, K. L.; Iezzoni, A. F.; VanBuren, R.; Hollender, C. A.

10.1101/2023.01.10.523438 — genomics — Posted on 2023-01-11

2876 Isogenic lines of rainbow trout (Oncorhynchus mykiss) as a tool to assess how growth and feeding behaviour are correlated to feed efficiency in fish

Pouil, S.; Kerneis, T.; Quillet, E.; Lallias, D.; Labbe, L.; Phocas, F.; Dupont-Nivet, M.

10.1101/2023.01.10.523400 — genetics — Posted on 2023-01-11

2877 dentist: Computing uncertainty by sampling points around maximum likelihood estimates

Boyko, J.; O'Meara, B.

10.1101/2023.01.10.523430 — evolutionary biology — Posted on 2023-01-11

2878 Nest site selection and productivity of a critically endangered parrot, the great green macaw (Ara ambiguus) in an anthropogenic landscape

Lewis, T. C.; Gutierrez Vargas, I.; Vredenbregt, C.; Jimenez, M.; Hatchwell, B.; Beckerman, A.; Childs, D.

10.1101/2023.01.10.523381 — ecology — Posted on 2023-01-11

2879 Let there be nightlights: the ecological role of bioluminescence in a Costa Rican mushroom

Adams, C. A.; Donald, M. L.; Swearingen, C.; Escudero, E.; Sourell, S.; Landrein, S.; Seas, C.; Mueller, G.; Chaverri, P.

10.1101/2023.01.10.523474 — ecology — Posted on 2023-01-11

2880 The great acceleration of island saturation by species introductions in the Anthropocene has altered species-area relationships

Gleditsch, J. M.; Behm, J. E.; Helmus, M. R.

10.1101/2023.01.10.523426 — ecology — Posted on 2023-01-11

2881 Intrinsic microtubule destabilization of multiciliated choroid plexus epithelial cells during postnatal lifetime

Ho, K. H.; Scarpetta, V.; Salio, C.; D'Este, E.; Meschkat, M.; Wurm, C. A.; Kneussel, M.; Janke, C.; Magiera, M. M.; Sassoe-Pognetto, M.; Brill, M. S.; Patrizi, A.

10.1101/2023.01.10.523428 — developmental biology — Posted on 2023-01-11

2882 Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of epithelial cells from nasal polyps

Kim, J.; Hegener, K.; Hagedorn, C.; Jamal Jameel, K.; Weidinger, D.; Seuthe, I. M. C.; Eichhorn, S.; Kreppel, F.; Park, J. J.-H.; Knobloch, J.

10.1101/2023.01.10.522992 — cell biology — Posted on 2023-01-11

2883 Origin Matters: Using a Local Reference Genome Improves Measures in Population Genomics

Thorburn, D.-M. J.; Sagonas, K.; Binzer-Panchal, M.; Chain, F. J.; Feulner, P.; Bornberg-Bauer, E.; Reusch, T.; Samonte-Padilla, I. E.; Milinski, M.; Lenz, T.; Eizaguirre, C.

10.1101/2023.01.10.523267 — bioinformatics — Posted on 2023-01-11

2884 Benchmark and optimization of AlphaFold structures based virtual screening strategy

Peng, Y.; Wu, X.; Lin, L.; Deng, Z.; Zhao, L.; Ke, H.

10.1101/2023.01.10.523376 — bioinformatics — Posted on 2023-01-11

2885 CellCharter: a scalable framework to chart and compare cell niches across multiple samples and spatial -omics technologies.

Varrone, M.; Tavernari, D.; Santamaria-Martinez, A.; Ciriello, G.

10.1101/2023.01.10.523386 — bioinformatics — Posted on 2023-01-11

2886 Smooth Muscle Cell Death Drives an Osteochondrogenic Phenotype and Severe Proximal Vascular Disease in Progeria

Murtada, S.-I.; Kawamura, Y.; Cavinato, C.; Wang, M.; Ramachandra, A. B.; Spronck, B.; Tellides, G.; Humphrey, J.

10.1101/2023.01.10.523266 — bioengineering — Posted on 2023-01-11

2887 Molecular Mechanocytometry Using Tension-activated Cell Tagging (TaCT)

Ma, R.; Velusamy, A.; Rashid, A.; Deal, B. R.; Chen, W.; Petrich, B.; Li, R.; Salaita, K.

10.1101/2023.01.10.523449 — bioengineering — Posted on 2023-01-11

2888 Firing-rate-modulated spike detection and neural decoding co-design

Zhang, Z.; Constandinou, T.

10.1101/2023.01.10.523472 — bioengineering — Posted on 2023-01-11

2889 The identification and analysis of meristematic mutations within the apple tree that developed the RubyMac sport mutation

Sun, H.; Abeli, P.; Campoy, J. A.; Ruetjes, T.; Krause, K.; Jiao, W.-B.; von Korff, M.; Beaudry, R.; Schneeberger, K.

10.1101/2023.01.10.523380 — genomics — Posted on 2023-01-11

2890 Multimodal Data Integration Advances Longitudinal Prediction of the Naturalistic Course of Depression and Reveals a Multimodal Signature of Disease Chronicity

Habets, P. C.; Thomas, R. M.; Milaneschi, Y.; Jansen, R.; Pool, R.; Peyrot, W. J.; Penninx, B. W.; Meijer, O. C.; van Wingen, G. A.; Vinkers, C. H.

10.1101/2023.01.10.523383 — genomics — Posted on 2023-01-11

2891 SURFBAT: a surrogate family-based association test building on large imputation reference panels

Herzig, A. F.; Rubinacci, S.; Marenne, G.; Perdry, H.; FrEx Consortium, ; FranceGenRef Consortium, ; Dina, C.; Redon, R.; Delaneau, O.; Genin, E.

10.1101/2023.01.10.523404 — genetics — Posted on 2023-01-11

2892 Adult stem cell characterization from the Medial Gastrocnemius and Semitendinosus muscles in early development of cerebral palsy pathology

Corvelyn, M.; Meirlevede, J.; Deschrevel, J.; Huyghe, E.; De Wachter, E.; Gayan-Ramirez, G.; Sampaolesi, M.; Van Campenhout, A.; Desloovere, K.; Costamagna, D.

10.1101/2023.01.10.523388 — developmental biology — Posted on 2023-01-11

2893 Automating microbial taxonomy workflows with PHANTASM: PHylogenomic ANalyses for the TAxonomy and Systematics of Microbes

Wirth, J. S.; Bush, E. C.

10.1101/2022.10.18.512716 — bioinformatics — Posted on 2023-01-11

2894 Phylogeographic reconstruction of the emergence and spread of Powassan virus in the northeastern United States

Vogels, C. B. F.; Brackney, D. E.; Dupuis, A. P.; Robich, R. M.; Fauver, J. R.; Brito, A. F.; Williams, S. C.; Anderson, J. F.; Lubelczyk, C. B.; Lange, R. E.; Prusinski, M. A.; Kramer, L. D.; Gangloff-Kaufmann, J. L.; Goodman, L. B.; Baele, G.; Smith, R. P.; Armstrong, P. M.; Ciota, A. T.; Dellicour, S.; Grubaugh, N. D.

10.1101/2022.10.14.512245 — genomics — Posted on 2023-01-11

2895 Spatial replication can best advance our understanding of population responses to climate

Compagnoni, A.; Evers, S.; Knight, T.

10.1101/2022.06.24.497542 — ecology — Posted on 2023-01-11

2896 Non-invasive assessment of normal and impaired iron homeostasis in living human brains.

Filo, S.; Shaharabani, R.; Bar Hanin, D.; Adam, M.; Ben-David, E.; Schoffman, H.; Margalit, N.; Habib, N.; Shahar, T.; Mezer, A.

10.1101/2022.05.02.490254 — neuroscience — Posted on 2023-01-11

2897 Rapid structural remodeling of peripheral taste fibers is independent of taste cell turnover

Whiddon, Z. D.; Marshall, J.; Alston, D. C.; McGee, A. W.; Krimm, R. F.

10.1101/2022.11.17.513266 — neuroscience — Posted on 2023-01-11

2898 The role of calcium, Akt and ERK signaling in cadmium-induced hair cell death

Galdieri, J.; Adams, C.; Padilla, M.; Stawicki, T. M.

10.1101/2022.08.15.504004 — neuroscience — Posted on 2023-01-11

2899 Principal component analysis- and tensor decomposition-based unsupervised feature extraction to select more reasonable differentially methylated cytosines: Optimization of standard deviation versus state-of-the-art methods

Taguchi, Y.-h.; Turki, T.

10.1101/2022.04.02.486807 — bioinformatics — Posted on 2023-01-11

2900 Divergence of trafficking and polarity mechanisms for PIN auxin transporters during land plant evolution

Tang, H.; Lu, K.-J.; Chang, Y.; Cheng, Y.-L.; Tu, S.-L.; Friml, J.

10.1101/2022.04.28.489888 — evolutionary biology — Posted on 2023-01-11

2901 Site-suitability difference and the expectation of species richness difference in stochastic two-subcommunities models

Iritani, R.

10.1101/2023.01.01.522407 — ecology — Posted on 2023-01-11

2902 Acute manipulation and real-time visualization of membrane trafficking and exocytosis in Drosophila

Glashauser, J.; Camelo, C.; Hollmann, M.; Backer, W.; Jacobs, T.; Isasti Sanchez, J.; Schleutker, R.; Forster, D.; Berns, N.; Riechmann, V.; Luschnig, S.

10.1101/2022.03.25.483021 — cell biology — Posted on 2023-01-11

2903 Viral and host small RNA transcriptome analysis of SARS-CoV-1 and SARS-CoV-2-infected human cells reveals novel viral short RNAs.

Driedonks, T.; Nyberg, L.; Conte, A.; Ma, Z.; Pekosz, A.; Duban, E.; Sültmann, H.; Turchinovich, A.; Witwer, K.

10.1101/2022.12.27.522023 — molecular biology — Posted on 2023-01-11

2904 Deconfounded Dimension Reduction via Partial Embeddings

Chen, A. A.; Clark, K.; Dewey, B.; DuVal, A.; Pellegrini, N.; Nair, G.; Jalkh, Y.; Khalil, S.; Zurawski, J.; Calabresi, P.; Reich, D.; Bakshi, R.; Shou, H.; Shinohara, R. T.

10.1101/2023.01.10.523448 — neuroscience — Posted on 2023-01-11

2905 Characterization and Applications of Evoked Responses During Epidural Electrical Stimulation

Verma, N.; Romanauski, B.; Lam, D.; Lujan, L.; Blanz, S.; Ludwig, K.; Lempka, S.; Knudsen, B.; Nishiyama, Y.; Hao, J.; Park, H.-J.; Ross, E.; Lavrov, I.; Zhang, M.

10.1101/2023.01.10.523453 — physiology — Posted on 2023-01-11

2906 Afrothismiaceae (Dioscoreales), a new fully mycoheterotrophic family endemic to tropical Africa

Cheek, M.; Gomez, M. S.; Graham, S. W.; Rudall, P.

10.1101/2023.01.10.523343 — plant biology — Posted on 2023-01-11

2907 Updated phylogeny and protein structure predictions revise the hypothesis on the origin of MADS-box transcription factors in land plants

Qiu, Y.; Li, Z.; Walther, D.; Köhler, C.

10.1101/2023.01.10.523452 — plant biology — Posted on 2023-01-11

2908 MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites

Wang, C.; Dong, Y.; Oberstaller, J.; Li, C.; Zhang, M.; Gibbons, J.; Pires, C. V.; Zhu, L.; Jiang, R.; Kim, K.; Miao, J.; Otto, T. D.; Cui, L.; Adams, J. H.; Liu, X.

10.1101/2022.09.21.508539 — bioinformatics — Posted on 2023-01-11

2909 A multivariate network analysis of ring- and diffuse-porous tree xylem vasculature segmented by convolutional neural networks

Huber, A. E.; Haft-Javaherian, M.; Berg, M.; Lanba, A.; Lorthois, S.; Bauerle, T. L.; Nishimura, N.

10.1101/2023.01.10.523508 — plant biology — Posted on 2023-01-11

2910 Evolutionary history of Castanea sativa Mill. in the Caucasus driven by Middle and Late Pleistocene paleoenvironmental changes

Beridze, B.; Sekiewicz, K.; Walas, L.; Thomas, P. A.; Danelia, I.; Kvartskhava, G.; Fazaliyev, V.; Bruch, A. A.; Dering, M.

10.1101/2023.01.11.523563 — evolutionary biology — Posted on 2023-01-11

2911 A general time-in, time-out model for the evolution of nuptial gift-giving

Charmouh, A. P.; Bilde, T.; Bocedi, G.; Duthie, A. B.

10.1101/2023.01.11.523385 — evolutionary biology — Posted on 2023-01-11

2912 Response to Tcherkez and Farquhar: Rubisco adaptation is more limited by phylogenetic constraint than by catalytic trade-off

Bouvier, J. W.; Kelly, S.

10.1101/2023.01.07.523088 — evolutionary biology — Posted on 2023-01-11

2913 Growth in a biofilm promotes conjugation of a blaNDM-1-bearing plasmid between Klebsiella pneumoniae strains

Element, S. J.; Moran, R. A.; Beattie, E.; Hall, R. J.; van Schaik, W.; Buckner, M. M. C.

10.1101/2023.01.05.522703 — microbiology — Posted on 2023-01-11

2914 Evidence for an RNAi-independent role of DICER-LIKE2 in conferring growth inhibition and basal antiviral resistance

Nielsen, C. P. S.; Arribas-Hernandez, L.; Han, L.; Andersen, S. U.; Pumplin, N.; Brodersen, P.

10.1101/2023.01.10.523401 — plant biology — Posted on 2023-01-11

2915 Sensing of viral RNA in plants via a DICER-LIKE Ribonuclease

Nielsen, C. P. S.; Han, L.; Arribas-Hernandez, L.; Karelina, D.; Petersen, M.; Brodersen, P.

10.1101/2023.01.10.523395 — plant biology — Posted on 2023-01-11

2916 miRCurator: A rapid curation and analysis tool for plantmicroRNA studies

Avsar, B.; Esmaeili Aliabadi, D.

10.1101/2023.01.10.523394 — bioinformatics — Posted on 2023-01-11

2917 Organisms employ a mode-switching strategy for solving the explore-vs-exploit problem

Biswas, D.; Lamperski, A.; Yang, Y.; Hoffman, K.; Guckenheimer, J.; Fortune, E. S.; Cowan, N. J.

10.1101/2023.01.11.523566 — animal behavior and cognition — Posted on 2023-01-11

2918 Photosynthetic and water transport strategies of plants along a tropical forest aridity gradient: a test of optimality theory

Zhang-Zheng, H.; Malhi, Y.; Gvozdevaite, A.; Peprah, T.; Boackye, M.; Zieminska, K.; Adu-Bredu, S.; Aguirre-Gutierrez, J.; Sandoval, D.; Prentice, C.; Oliveras, I.

10.1101/2023.01.10.523419 — ecology — Posted on 2023-01-11

2919 Virome analyses by next-generation sequencing (NGS) in chilli (Capsicum anuum L.) presented with diverse symptoms phenotype revealed the association of seven plant viruses

Reddy, N. V.; Hiremath, S.; Muttappagol, M.; H. D., V. k.; Koti, P. S.; T. L., M. K.; C. R., J. B.; K. S., S.; V, V.; Reddy, C. N. L.

10.1101/2023.01.11.523546 — molecular biology — Posted on 2023-01-11

2920 Defective engram allocation contributes to impaired fear memory performance in Down syndrome

Fernandez-Blanco, A.; Zamora-Moratalla, A.; Sabariego-Navarro, M.; Dierssen, M.

10.1101/2023.01.11.523460 — neuroscience — Posted on 2023-01-11

2921 Human-specific features and developmental dynamics of the brain N-glycome

Klaric, T. S.; Gudelj, I.; Santpere, G.; Sousa, A. M. M.; Novokmet, M.; Vuckovic, F.; Ma, S.; Beceheli, I.; Sherwood, C. C.; Ely, J. J.; Hof, P. R.; Josic, D.; Lauc, G.; Sestan, N.

10.1101/2023.01.11.523525 — neuroscience — Posted on 2023-01-11

2922 A dominant-negative avirulence effector of the barley powdery mildew fungus provides mechanistic insight to barley MLA immune receptor activation

Crean, E. E.; Bilstein-Schloemer, M.; Maekawa, T.; Schulze-Lefert, P.; Saur, I. M.-L.

10.1101/2023.01.11.523539 — plant biology — Posted on 2023-01-11

2923 How does the mode of evolutionary divergence affect reproductive isolation?

De Sanctis, B.; Schneemann, H.; Welch, J. J.

10.1101/2022.03.08.483443 — evolutionary biology — Posted on 2023-01-11

2924 Elucidation of the antiviral mechanism of natural therapeutic molecules Herbacetin and Caffeic acid phenethyl ester against Chikungunya and Dengue virus

Bhutkar, M.; Rani, R.; Kothiala, A.; Mahajan, S.; Waghmode, B.; Kumar, R.; Singh, V.; Sircar, D.; Kumar, P.; Tomar, S.

10.1101/2022.05.31.494145 — microbiology — Posted on 2023-01-11

2925 Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal - medial prefrontal cortex circuit during natural sleep in APPNL-G-F mice

Brady, E. S.; Griffiths, J.; Andrianova, L.; Saito, T.; Sado, T. C.; Randall, A. D.; Tamagnini, F.; Witton, J.; Craig, M.

10.1101/2022.02.08.479119 — neuroscience — Posted on 2023-01-11

2926 eIF2B localisation and its regulation during the integrated stress response is cell type specific

Hanson, F. M.; Ribeiro de Oliveira, M. I.; Cross, A. K.; Allen, K. E.; Campebll, S. G.

10.1101/2023.01.10.523470 — cell biology — Posted on 2023-01-11

2927 Immobilization of Lipophilic and Amphiphilic Biomarker on Hydrophobic Microbeads

Dinter, F.; Thiele, T.; Schedler, U.; Lehmann, W.; Schierack, P.; Roediger, S.

10.1101/2023.01.10.523433 — biochemistry — Posted on 2023-01-11

2928 Adolescent parvalbumin expression in the left orbitofrontal cortex shapes sociability in female mice

Jeon, Y.-S.; Jeong, D.; Kweon, H.; Kim, J.-H.; Kim, C. Y.; Oh, Y.; Lee, Y.-H.; Kim, C. H.; Kim, S.-G.; Jeong, J.-W.; Kim, E.; Lee, S.-H.

10.1101/2022.03.04.482801 — animal behavior and cognition — Posted on 2023-01-11

2929 How Occam's razor guides human decision-making

Piasini, E.; Liu, S.; Chaudhari, P.; Balasubramanian, V.; Gold, J. I.

10.1101/2023.01.10.523479 — neuroscience — Posted on 2023-01-10

2930 Unbalanced response to growth variations reshapes the cell fate decision landscape

Zhu, J.; Chu, P.; Fu, X.

10.1101/2022.09.13.507864 — systems biology — Posted on 2023-01-10

2931 Deep Domain Adversarial Neural Network for the Deconvolution of Cell Type Mixtures in Tissue Proteome Profiling

Wang, F.; Yang, F.; Huang, L.-K.; Song, J.; Gasser, R.; Aebersold, R.; Wang, G.; Yao, J.

10.1101/2022.11.25.517895 — bioinformatics — Posted on 2023-01-10

2932 Phylogenetic modeling of enhancer shifts in African mole-rats reveals regulatory changes associated with tissue-specific traits

Parey, E.; Frost, S.; Uribarren, A.; Park, T. J.; Zoettl, M.; Smith, E. S. J.; Berthelot, C.; Villar Lozano, D.

10.1101/2023.01.10.523217 — genomics — Posted on 2023-01-10

2933 Associative white matter tracts selectively predict sensorimotor learning

Vinci-Booher, S.; McDonald, D.; Berquist, E.; Pestilli, F.

10.1101/2023.01.10.523345 — neuroscience — Posted on 2023-01-10

2934 Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generation

Ma, W.; You, S.; Regnier, M.; McCammon, J. A.

10.1101/2022.09.22.508219 — biophysics — Posted on 2023-01-10

2935 A cinnamyl alcohol dehydrogenase (CAD) like enzyme leads to a branch in the shikonin biosynthetic pathway in Arnebia euchroma

Wang, R.; Liu, C.; Wang, S.; Sun, J.; Guo, J.; Lyu, C.; Kang, C.; Wan, X.; Shi, L.; Wang, J.; Huang, L.; Guo, L.

10.1101/2023.01.09.523192 — biochemistry — Posted on 2023-01-10

2936 The arginine dihydrolase pathway shapes human gut microbial community assembly, functions, and mammalian host colonization

Liu, Y.; Cheng, Y.-Y.; Zhou, Z.; Vivas, E. I.; Anantharaman, K.; Venturelli, O. S.

10.1101/2023.01.10.523442 — systems biology — Posted on 2023-01-10

2937 A tissue centric atlas of cell type transcriptome enrichment signatures

Dusart, P.; Öling, S.; Struck, E.; Norreen-Thorsen, M.; Zwahlen, M.; von Feilitzen, K.; Oksvold, P.; Bosic, M.; Iglesias, M. J.; Renne, T.; Odeberg, J.; Ponten, F.; Lindskog, C.; Uhlen, M.; Butler, L.

10.1101/2023.01.10.520698 — systems biology — Posted on 2023-01-10

2938 Systematic, Protein Activity-based Characterization of Single Cell State

Vlahos, L. J.; Obradovic, A.; Worley, J.; Tan, X.; Howe, A.; Laise, P.; Wang, A.-L.; Drake, C. G.; Califano, A.

10.1101/2021.05.20.445002 — systems biology — Posted on 2023-01-10

2939 Modeling and Analysis of a Cell-Free Gluconate Responsive Biosensor

Adhikari, A.; Murti, A.; Narayanan, A. N.; Lim, H. E.; Varner, J.

10.1101/2023.01.10.523462 — synthetic biology — Posted on 2023-01-10

2940 Carbohydrate distribution via SWEET17 is critical for Arabidopsis inflorescence branching under drought

Valifard, M.; Khan, A.; LE HIR, R.; Pommerrenig, B.; Neuhaus, H. E.; Keller, I.

10.1101/2023.01.10.523414 — plant biology — Posted on 2023-01-10

2941 Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14

Wang, M.; Zhong, Z.; Gallego-Bartolome, J.; Feng, S.; Shih, Y.-H.; Liu, M.; Zhou, J.; Richey, J. C.; Ng, C.; Jami-Alahmadi, Y.; Wohlschlegel, J.; Wu, K.; Jacobsen, S. E.

10.1101/2023.01.10.523456 — plant biology — Posted on 2023-01-10

2942 Canagliflozin extends life span and leads to less weight gain in C57BL6 male mice

Habeos, E. E.; Filippopoulou, F.; Kanakis, M.; Habeos, G. I.; Lagoumintzis, G.; Taraviras, S.; Chartoumpekis, D. V.

10.1101/2022.11.20.517248 — physiology — Posted on 2023-01-10

2943 Within-species differences in vocal production learning in a songbird are associated with differences in flexible rhythm pattern perception

Rouse, A. A.; Patel, A. D.; Wainapel, S.; Kao, M. H.

10.1101/2022.07.13.499954 — animal behavior and cognition — Posted on 2023-01-10

2944 Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes generation of the whole lung

10.1101/2022.10.31.514628 — developmental biology — Posted on 2023-01-10

2945 The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

Siegfried, H.; Le Borgne, R.; Durieu, C.; De Azevedo Laplace, T.; Verraes, A.; Daunas, L.; Verbavatz, J.-M.; Heuze, M. L.

10.1101/2022.10.17.512434 — cell biology — Posted on 2023-01-10

2946 Paresthesia during spinal cord stimulation depends on synchrony of dorsal column axon activation

Sagalajev, B.; Zhang, T.; Abdollahi, N.; Yousefpour, N.; Medlock, L.; Al-Basha, D.; Ribeiro-da-Silva, A.; Esteller, R.; Ratte, S.; Prescott, S. A.

10.1101/2023.01.10.523167 — neuroscience — Posted on 2023-01-10

2947 Atlasing white matter and grey matter joint contributions to resting-state networks in the human brain

Nozais, V.; Forkel, S. J.; Petit, L.; Talozzi, L.; Corbetta, M.; Thiebaut de Schotten, M.; joliot, m.

10.1101/2022.01.10.475690 — neuroscience — Posted on 2023-01-10

2948 Worth the work? Monkeys discount rewards by a subjective adapting effort cost

Burrell, M.; Pastor-Bernier, A.; Schultz, W.

10.1101/2023.01.10.523384 — neuroscience — Posted on 2023-01-10

2949 Competing Decision-Making Systems Are Adaptively Chosen Based on Individual Differences in Brain Connectivity

Yang, Y. C.; Sibert, C.; Stocco, A.

10.1101/2023.01.10.523458 — neuroscience — Posted on 2023-01-10

2950 The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.

Li, Z.; Wang, M.; Zhong, Z.; Gallego-Bartolome, J.; Feng, S.; Jami-Alahmadi, Y.; Wang, X.; Wohlschlegel, J.; Bischof, S.; Long, J. A.; Jacobsen, S. E.

10.1101/2023.01.10.523455 — plant biology — Posted on 2023-01-10

2951 Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity.

Ripa, R.; Ballhysa, E.; Steiner, J.; Annibal, A.; Hochhard, N.; Latza, C.; Dolfi, L.; Calabrese, C.; Meyer, A.; Polidori, M. C.; Mueller, R.-U.; Antebi, A.

10.1101/2022.12.05.519139 — physiology — Posted on 2023-01-10

2952 Breathe Easy, an automated respiratory data pipeline for waveform characteristic analysis

Lusk, S.; Ward, C. S.; Chang, A.; Twitchell-Heyne, A.; Fattig, S.; Allen, G.; Jankowsky, J.; Ray, R.

10.1101/2022.12.02.518741 — physiology — Posted on 2023-01-10

2953 Exploiting allele-specific transcriptional effects of subclonal copy number alterations for genotype-phenotype mapping in cancer cell populations

Shi, H.; Williams, M. J.; Satas, G.; Weiner, A. C.; McPherson, A.; Shah, S. P.

10.1101/2023.01.10.523464 — cancer biology — Posted on 2023-01-10

2954 Non-invasive investigation of the morphology and optical properties of the upside-down jellyfish Cassiopea with optical coherence tomography

Lyndby, N. H.; Murthy, S.; Bessette, S.; Jakobsen, S. L.; Meibom, A.; Kühl, M.

10.1101/2023.01.10.523435 — biophysics — Posted on 2023-01-10

2955 Single Molecule Mechanics and Kinetics of Cardiac Myosin Interacting with Regulated Thin Filaments

Clippinger Schulte, S. R.; Scott, B.; Barrick, S. K.; Stump, W. T.; Blackwell, T.; Greenberg, M. J.

10.1101/2023.01.09.522880 — biophysics — Posted on 2023-01-10

2956 Dynein dysfunction prevents maintenance of high concentrations of slow axonal transport cargos at the axon terminal: a computational study

Kuznetsov, I. A.; Kuznetsov, A. V.

10.1101/2022.06.19.496644 — biophysics — Posted on 2023-01-10

2957 Rethinking bacterial relationships in light of their molecular abilities

Mahlich, Y.; Zhu, C.; Chung, H.; Velaga, P. K.; de Paolis Kaluza, M. C.; Radivojac, P.; Friedberg, I.; Bromberg, Y.

10.1101/2022.11.28.518265 — bioinformatics — Posted on 2023-01-10

2958 VStrains: De Novo Reconstruction of Viral Strains via Iterative Path Extraction From Assembly Graphs

Luo, R.; Lin, Y.

10.1101/2022.10.21.513181 — bioinformatics — Posted on 2023-01-10

2959 Deep learning-based predictive identification of functional subpopulations of hematopoietic stem cells and multipotent progenitors

Wang, S.; Han, J.; Huang, J.; Shi, Y.; Zhou, Y.; Kim, D.; Islam, M. K.; Zhou, J.; Ostrovsky, O.; Li, C.; Lian, Z.; Liu, Y.; Huang, J.

10.1101/2022.12.19.519644 — bioengineering — Posted on 2023-01-10

2960 Graph Convolutional Learning of Multimodal Brain Connectome Data for Schizophrenia Classification

Ghosh, S.; Bhargava, E.; Lin, C.-T.; Nagarajan, S. S.

10.1101/2023.01.05.522960 — bioengineering — Posted on 2023-01-10

2961 Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets

Tahti, E. F.; Blount, J. M.; Jackson, S. N.; Gao, M.; Gill, N. P.; Smith, S. N.; Pederson, N. J.; Rumph, S. N.; Struyvenberg, S. A.; Mackley, I. G. P.; Madden, D. R.; Amacher, J.

10.1101/2022.12.31.522388 — biochemistry — Posted on 2023-01-10

2962 Genome-Wide Association Study Finds Multiple Loci Associated with Intraocular Pressure in HS Rats

Fowler, S.; Wang, T.; Munro, D.; Kumar, A.; Chitre, A. S.; Hollingsworth, T.; Martinez, A. G.; St. Pierre, C. L.; Bimschleger, H.; Gao, J.; Cheng, R.; Mohammadi, P.; Chen, H.; Palmer, A. A.; Polesskaya, O.; Jablonski, M. M.

10.1101/2022.08.16.503865 — genomics — Posted on 2023-01-10

2963 Heritable maize microbiomes contribute to local adaptation and host stress resilience

He, X.; Wang, D.; Jiang, Y.; Li, M.; Delgado-Baquerizo, M.; McLaughlin, C.; Marcon, C.; Baer, M.; Guo, L.; Moya, Y. A. T.; von Wiren, N.; Deichmann, M.; Schaaf, G.; Piepho, H.-P.; Yang, Z.; Yang, J.; Yim, B.; Smalla, K.; Goormachtig, S.; de Vries, F. T.; Huging, H.; Sawers, R. J. H.; Reif, J. C.; Hochholdinger, F.; Chen, X.; Yu, P.

10.1101/2023.01.10.523403 — genetics — Posted on 2023-01-10

2964 Preventing multiple resistance above all: new insights for managing fungal adaptation

Ballu, A.; Ugazio, C.; Duplaix, C.; Noly, A.; Wullschleger, J.; Torriani, S. F. F.; Deredec, A.; Carpentier, F.; Walker, A.-S.

10.1101/2022.12.17.520869 — evolutionary biology — Posted on 2023-01-10

2965 Information integration during bioelectric regulation of morphogenesis in the embryonic frog brain

Manicka, S.; Pai, V. P.; Levin, M.

10.1101/2023.01.08.523164 — developmental biology — Posted on 2023-01-10

2966 Emergent dynamics of adult stem cell lineages from single nucleus and single cell RNA-Seq of Drosophila testes

10.1101/2022.07.26.501581 — developmental biology — Posted on 2023-01-10

2967 A hierarchical pathway for assembly of the distal appendages that organize primary cilia

Kanie, T.; Love, J. F.; Fisher, S. D.; Gustavsson, A.-K.; Jackson, P. K.

10.1101/2023.01.06.522944 — cell biology — Posted on 2023-01-10

2968 Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages

Kanie, T.; Ng, R.; Abbott, K. L.; Pongs, O.; Jackson, P. K.

10.1101/2023.01.06.523037 — cell biology — Posted on 2023-01-10

2969 Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons

Grenier, T.; Consuegra, J.; Galvao Ferrarini, M.; Akherraz, H.; Bai, L.; Dusabyinema, Y.; Rahioui, I.; da Silva, P.; Gillet, B.; Hughes, S.; Ramos, C.; Matos, R.; Leulier, F.

10.1101/2021.10.31.466661 — microbiology — Posted on 2023-01-10

2970 In situ structures of secretins from bacterial type II secretion system reveal their membrane interactions and translocation process

Yu, Z.; Wu, Y.; Chen, M.; Huo, T.; Zheng, W.; Ludtke, S.; Shi, X.; Wang, Z.

10.1101/2023.01.10.523476 — microbiology — Posted on 2023-01-10

2971 The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus

10.1101/2021.08.18.456792 — immunology — Posted on 2023-01-10

2972 Dihydroxy-Metabolites of Dihomo-gamma-linolenic Acid Drive Ferroptosis- Mediated Neurodegeneration

Sarparast, M.; Pourmand, E.; Hinman, J.; Vonarx, D.; Reason, T.; Zhang, F.; Paithankar, S.; Chen, B.; Borhan, B.; Watts, J. L.; Alan, J.; Lee, K. S. S.

10.1101/2023.01.05.522933 — neuroscience — Posted on 2023-01-10

2973 Neuromuscular connectomes across development reveal synaptic ordering rules

Meirovitch, Y.; Kang, K.; Draft, R. W.; Pavarino, E. C.; Henao Echeverri, M. F.; Yang, F.; Turney, S. G.; Berger, D. R.; Peleg, A.; Montero-Crespo, M.; Schaleck, R. L.; Lu, J.; Livet, J.; Tapia, J.-C.; Lichtman, J. W.

10.1101/2021.09.20.460480 — neuroscience — Posted on 2023-01-10

2974 Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators

Kuhnisch, J.; Theisen, S.; Dartsch, J.; Fritsche-Guenther, R.; Kirchner, M.; Obermayer, B.; Bauer, A.; Kahlert, A.-K.; Rothe, M.; Beule, D.; Heuser, A.; Mertins, P.; Kirwan, J. A.; Berndt, N.; MacRae, C. A.; Hubner, N.; Klaassen, S.

10.1101/2023.01.10.523243 — pathology — Posted on 2023-01-10

2975 Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

Beach, C.; MacLean, D.; Majorova, D.; Melemenidis, S.; Nambiar, D. K.; Kim, R. K.; Valbuena, G. N.; Guglietta, S.; Krieg, C.; Damavandi, M. D.; Suwa, T.; Easton, A.; Domingo, E.; Moon, E. J.; Jiang, D.; Jiang, Y.; Koong, A. C.; Woodruff, T. M.; Graves, E. E.; Maughan, T.; Buczacki, S. J.; Stucki, M.; Le, Q.-T.; Leedham, S. J.; Giaccia, A. J.; Olcina, M. M.

10.1101/2023.01.10.521547 — cancer biology — Posted on 2023-01-10

2976 Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment

Colombani, T.; Rogers, Z.; Bhatt, K.; Sinoimeri, J.; Gerbereux, L.; Hamrangsekachaee, M.; Bencherif, S. A.

10.1101/2023.01.10.523477 — cancer biology — Posted on 2023-01-10

2977 Androgen-mediated TGFβ expression suppresses anti-tumor neutrophil response in bone metastatic prostate cancer

Alsamraae, M.; Costanzo-Garvey, D.; Teply, B. A.; Boyle, S.; Sommerville, G.; Herbert, Z.; Morrissey, C.; Dafferner, A. J.; Abdalla, M. Y.; Fallet, R. W.; Kielian, T.; Jensen-Smith, H.; deOliveira, E. I.; Chen, K.; Bettencourt, I. A.; Wang, J. M.; McVicar, D. W.; Keeley, T.; Yu, F.; Cook, L. M.

10.1101/2022.12.30.522329 — cancer biology — Posted on 2023-01-10

2978 Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion

Alshahrany, N.; Jimenez-Pascual, A.; Siebzehnrubl, F. A.

10.1101/2023.01.10.523434 — cancer biology — Posted on 2023-01-10

2979 Streamlined Structure Determination by Cryo-Electron Tomography and Subtomogram Averaging using TomoBEAR

Balyschew, N.; Yushkevich, A.; Mikirtumov, V.; Sanchez, R. M.; Sprink, T.; Kudryashev, M.

10.1101/2023.01.10.523437 — biophysics — Posted on 2023-01-10

2980 Disease-associated patterns of acetylation stabilize tau fibril formation

Li, L.; Nguyen, B.; Mullapudi, V.; Saelices, L.; Joachimiak, L. A.

10.1101/2023.01.10.523459 — biophysics — Posted on 2023-01-10

2981 Physical mechanisms of red blood cell splenic filtration

Moreau, A.; Yaya, F.; Lu, H.; Surendranath, A.; Charrier, A.; Dehapiot, B.; Helfer, E.; Viallat, A.; Peng, Z.

10.1101/2023.01.10.523245 — biophysics — Posted on 2023-01-10

2982 Trade-offs between cost and information in cellular prediction

Tjalma, A. J.; Galstyan, V.; Goedhart, J.; Slim, L.; Becker, N. B.; ten Wolde, P. R.

10.1101/2023.01.10.523390 — biophysics — Posted on 2023-01-10

2983 Automating microbial taxonomy workflows with PHANTASM: PHylogenomic ANalyses for the TAxonomy and Systematics of Microbes

Wirth, J. S.; Bush, E. C.

10.1101/2022.10.18.512716 — bioinformatics — Posted on 2023-01-10

2984 Comprehensive approach to study branched ubiquitinchains reveals roles for K48-K63 branches inVCP/p97-related processes

Lange, S. M.; McFarland, M. R.; Lamoliatte, F.; Kwasna, D.; Shen, L.; Wallace, I.; Cole, I.; Armstrong, L. A.; Knebel, A.; Johnson, C.; De Cesare, V.; Kulathu, Y.

10.1101/2023.01.10.523363 — biochemistry — Posted on 2023-01-10

2985 Immobilization of Lipophilic and Amphiphilic Biomarker on Hydrophobic Microbeads

Dinter, F.; Thiele, T.; Schedler, U.; Lehmann, W.; Schierack, P.; Roediger, S.

10.1101/2023.01.10.523433 — biochemistry — Posted on 2023-01-10

2986 Tissue-specific sex difference in mouse eye and brain metabolome under fed and fasted states

Saravanan, M.; Xu, R.; Roby, O.; Wang, Y.; Zhu, S.; Lu, A.; Du, J.

10.1101/2023.01.10.523270 — biochemistry — Posted on 2023-01-10

2987 The effect of sociality on competitive interactions among birds

Berberi, I.; Miller, E. T.; Dakin, R.

10.1101/2022.05.09.491173 — animal behavior and cognition — Posted on 2023-01-10

2988 Multidrug resistance plasmids underlie clonal expansions and international spread of Salmonella enterica serotype 4,,12,i:- ST34 in Southeast Asia

Chung The, H.; Pham, P.; Thanh Tuyen, H.; Vo Kim Phuong, L.; Phuong Yen, N. T.; Le, S.-N. H.; Duong, V. T.; Chau, T. T. H.; Phuc, H. L.; Ngoc, N. M.; Lan Vi, L.; Mather, A.; Thwaites, G.; Thomson, N. R.; Baker, S.; Pham, D. T.

10.1101/2023.01.10.523379 — genomics — Posted on 2023-01-10

2989 Introgressive descent and hypersexuality drive the evolution of sexual parasitism and morphological reduction in a fungal species complex.

Fernandez-Mendoza, F.; Strasser, E.; Frolov, I.; Vondrak, J.; Muggia, L.; Mayrhofer, H.; Gaya, E.; Grube, M.

10.1101/2023.01.10.523206 — evolutionary biology — Posted on 2023-01-10

2990 eIF2B localisation and its regulation during the integrated stress response is cell type specific

Hanson, F. M.; Ribeiro de Oliveira, M. I.; Cross, A. K.; Allen, K. E.; Campebll, S. G.

10.1101/2023.01.10.523470 — cell biology — Posted on 2023-01-10

2991 Long Non-Coding RNA Generated from CDKN1A Gene by Alternative Polyadenylation Regulates p21 Expression during DNA Damage Response

Murphy, M. R.; Ramadei, A.; Doymaz, A.; Varriano, S.; Natelson, D. M.; Yu, A.; Aktas, S.; Mazzeo, M.; Mazzeo, M.; Zakusilo, G.; Kleiman, F. E.

10.1101/2023.01.10.523318 — molecular biology — Posted on 2023-01-10

2992 Adaptive evolution of hearing genes suggests multiple evolutionary paths for dolphin echolocation in different environments.

Magpali, L.; Freitas Nery, M.; Freitas, L.; Karen Sousa Ramos, E.; Silva de Souza, E. M.

10.1101/2023.01.10.523466 — molecular biology — Posted on 2023-01-10

2993 Uncovering the Dynamics of Precise Repair at CRISPR/Cas9-induced Double-Strand Breaks

Ben-Tov, D.; Mafessoni, F.; Cucuy, A.; Honig, A.; Bessudo, C.; Levy, A. A.

10.1101/2023.01.10.523377 — molecular biology — Posted on 2023-01-10

2994 Inspiration of SARS-CoV-2 envelope protein mutations on pathogenicity of Omicron XBB

Gao, Z.-b.; Wang, Y.; Ji, H.; Zuo, X.; Xia, B.

10.1101/2023.01.09.523338 — microbiology — Posted on 2023-01-10

2995 Intracytoplasmic membranes develop in Geobacter sulfurreducens under thermodynamically limiting conditions

Howley, E. T.; Mangus, A. M.; Williams, D. R.; Torres, C. I.

10.1101/2022.08.05.502997 — microbiology — Posted on 2023-01-10

2996 Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed myelinating oligodendrocytes in PLP1 mutant mice

Abdelwahab, T.; Stadler, D.; Knopper, K.; Arampatzi, P.; Saliba, A.-E.; Kastenmuller, W.; Martini, R.; Groh, J.

10.1101/2023.01.10.523231 — neuroscience — Posted on 2023-01-10

2997 Electrophysiological signatures of spelling sensitivity development from primary school age to adulthood

Larionova, E.; Rebreikina, A.; Martynova, O.

10.1101/2023.01.10.523398 — neuroscience — Posted on 2023-01-10

2998 Sickle cell disease patient plasma sensitizes iPSC-derived sensory neurons from sickle cell disease patients

Allison, R. L.; Burand, A.; Nieves Torres, D.; Brandow, A. M.; Stucky, C. L.; Ebert, A.

10.1101/2023.01.10.523446 — neuroscience — Posted on 2023-01-10

2999 Estimation of animal location from grid cell populationactivity using persistent cohomology

Kawahara, D.; Fujisawa, S.

10.1101/2023.01.10.523361 — neuroscience — Posted on 2023-01-10

3000 Natural stimuli drive concerted nonlinear responses in populations of retinal ganglion cells

Karamanlis, D.; Khani, M. H.; Schreyer, H. M.; Zapp, S. J.; Mietsch, M.; Gollisch, T.

10.1101/2023.01.10.523412 — neuroscience — Posted on 2023-01-10

3001 Knockout of Sporadic Creutzfeldt-Jakob Disease Risk Gene Stx6 in Mice Extends Prion Disease Incubation Time

Jones, E.; Hill, E.; Linehan, J.; Nazari, T.; Caulder, A.; Codner, G. F.; Hutchison, M.; Mackenzie, M.; Wiggins De Oliveira, M.; Al-Doujaily, H.; Sandberg, M.; Vire, E.; Cunningham, T. J.; Asante, E. A.; Brandner, S.; Collinge, J.; Mead, S.

10.1101/2023.01.10.523281 — neuroscience — Posted on 2023-01-10

3002 Navigation and the Efficiency of Spatial Coding: Insights from Closed-Loop Simulations

Ghazinouri, B.; Mohagheghi Nejad, M.; Cheng, S.

10.1101/2023.01.10.523425 — neuroscience — Posted on 2023-01-10

3003 Evolutionarily acquired activity-dependent transformation of the CaMKII holoenzyme

Tsujioka, S.; Sumino, A.; Nagasawa, Y.; Sumikama, T.; Flechsig, H.; Puppulin, L.; Tomita, T.; Baba, Y.; Kakuta, T.; Ogoshi, T.; Umeda, K.; Kodera, N.; Murakoshi, H.; Shibata, M.

10.1101/2023.01.10.523378 — neuroscience — Posted on 2023-01-10

3004 On the physiological and structural contributors to the dynamic balance of excitation and inhibition in local cortical networks

Shirani, F.; Choi, H.

10.1101/2023.01.10.523489 — neuroscience — Posted on 2023-01-10

3005 Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria

Purhonen, J.; Banerjee, R.; Wanne, V.; Sipari, N.; Morgelin, M.; Fellman, V.; Kallijarvi, J.

10.1101/2023.01.10.521980 — pathology — Posted on 2023-01-10

3006 Matrix vesicle isolation from a three-dimensional in vitro bone model

Ansari, S.; van Dasler, L.; Yuana, Y.; Castilho, M.; Ito, K.; Hofmann, S.

10.1101/2023.01.10.523451 — bioengineering — Posted on 2023-01-10

3007 Branched chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast

Blank, H. M.; Reuse, C.; Schmidt-Hohagen, K.; Hiller, K.; Polymenis, M.

10.1101/2023.01.10.523468 — biochemistry — Posted on 2023-01-10

3008 Comparing rapid rule-learning strategies in humans and monkeys

Goudar, V.; Kim, J.-W.; Liu, Y.; Dede, A. J. O.; Jutras, M. J.; Skelin, I.; Ruvalcaba, M.; Chang, W.; Fairhall, A. L.; Lin, J. J.; Knight, R. T.; Buffalo, E. A.; Wang, X.-J.

10.1101/2023.01.10.523416 — animal behavior and cognition — Posted on 2023-01-10

3009 Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2 strain WA1/2020 as well as variants delta and omicron.

Flamier, A.; Bisht, P.; Richards, A.; Tomasello, D. L.; Jaenisch, R.

10.1101/2023.01.10.523422 — neuroscience — Posted on 2023-01-10

3010 Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility.

Cola, R. B.; Roccaro, D. M.; Naim, S.; Babalian, A.; Seebeck, P.; Alvarez-Bolado, G.; Celio, M. R.

10.1101/2023.01.10.521942 — neuroscience — Posted on 2023-01-10

3011 Developmental hearing loss-induced perceptual deficits are rescued by cortical expression of GABAB receptors

Masri, S.; Fair, R.; Mowery, T. M.; Sanes, D. H.

10.1101/2023.01.10.523440 — neuroscience — Posted on 2023-01-10

3012 Thermal plasticity of wing spot size in Drosophila guttifera: investigating the relevance to Wingless morphogen

Fukutomi, Y.; Takahashi, A.; Koshikawa, S.

10.1101/2023.01.09.523128 — zoology — Posted on 2023-01-10

3013 Missing data in amortized simulation-based neural posterior estimation

Wang, Z.; Hasenauer, J.; Schaelte, Y.

10.1101/2023.01.09.523219 — systems biology — Posted on 2023-01-10

3014 Ketocarotenoid production in tomato triggers metabolic reprogramming and cellular adaptation: The quest for homeostasis?

Nogueira, M.; Enfissi, E. M. A.; Price, E. J.; Menard, G. N.; Venter, E.; Eastmond, P. J.; Bar, E.; Lewinsohn, E.; Fraser, P. D.

10.1101/2023.01.09.523254 — systems biology — Posted on 2023-01-10

3015 Integration of transcriptomics data into agent-based models of solid tumor metastasis

Retzlaff, J.; Lai, X.; Berking, C.; Vera, J.

10.1101/2023.01.09.523238 — systems biology — Posted on 2023-01-10

3016 HOGVAX: Exploiting Peptide Overlaps to Maximize Population Coverage in Vaccine Design with Application to SARS-CoV-2

Schulte, S. C.; Dilthey, A. T.; Klau, G. W.

10.1101/2023.01.09.523288 — bioinformatics — Posted on 2023-01-10

3017 Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load

Cody, J.; Ellis-Connell, A.; O'Connor, S.; Pienaar, E.

10.1101/2023.01.09.523305 — systems biology — Posted on 2023-01-10

3018 Identification, characterisation and recombinant expression of flavonoid 3',5'-hydroxylases and cytochrome P450 reductases from Vaccinium species

Kukk, K.

10.1101/2023.01.09.523147 — synthetic biology — Posted on 2023-01-10

3019 A Cellular Platform for Production of C4 Monomers

Davis, M. A.; Yu, V. Y.; Fu, B.; Wen, M.; Koleski, E. J.; Silverman, J.; Berdan, C. A.; Nomura, D. K.; Chang, M. C. Y.

10.1101/2023.01.09.523327 — synthetic biology — Posted on 2023-01-10

3020 Sirtuin 2 inhibition modulates chromatin landscapes genome- wide to induce senescence in ATRX-deficient malignant glioma

Malgulwar, P. B.; Danussi, C.; Dharmaiah, S.; Johnson, W.; Rao, A.; Huse, J. T.

10.1101/2023.01.09.523324 — cancer biology — Posted on 2023-01-10

3021 Spin-coupled electron densities of iron-sulfur cluster imaged by in situ serial Laue diffraction

Ren, Z.; Zhang, F.; Kang, W.; Wang, C.; Shin, H.; Zeng, X.; Gunawardana, S.; Bowatte, K.; Krauss, N.; Lamparter, T.; Yang, X.

10.1101/2023.01.09.523341 — biophysics — Posted on 2023-01-10

3022 Single Molecule Mechanics and Kinetics of Cardiac Myosin Interacting with Regulated Thin Filaments

Clippinger Schulte, S. R.; Scott, B.; Barrick, S. K.; Stump, W. T.; Greenberg, M. J.

10.1101/2023.01.09.522880 — biophysics — Posted on 2023-01-10

3023 BRDriver: Breast Cancer Driver Gene Predictor

Perera, R.; Perera, R.

10.1101/2023.01.09.523362 — bioinformatics — Posted on 2023-01-10

3024 FastRecomb: Fast inference of genetic recombination rates in biobank scale data

Naseri, A.; Yue, W.; Zhang, S.; Zhi, D.

10.1101/2023.01.09.523304 — bioinformatics — Posted on 2023-01-10

3025 MESH-FREE HIGH-RESOLUTION SIMULATION OF CEREBROCORTICAL OXYGENSUPPLY WITH FAST FOURIER PRECONDITIONING

Linninger, A.; Ventimiglia, T. A.

10.1101/2023.01.09.523320 — bioengineering — Posted on 2023-01-10

3026 The role of catalytic and regulatory domains of human PrimPol in DNA binding and synthesis

Boldinova, E. O.; Baranovskiy, A. G.; Gagarinskaya, D. I.; Makarova, A. V.; Tahirov, T. H.

10.1101/2023.01.09.523353 — biochemistry — Posted on 2023-01-10

3027 Why do cell-level test methods for detecting differentially expressed genes fail in single-cell RNA-seq data?

Lee, H.; Han, B.

10.1101/2023.01.09.523212 — genomics — Posted on 2023-01-10

3028 Whole genome sequencing of Red Chittagong Cattle (RCC) cattle and insight into genetic variants in candidate genes for disease resistance

Das, A.; Gupta, M. D.; Shaha, M.; Lima, A.; Miazi, O. F.; Das, G. B.

10.1101/2023.01.09.523278 — genomics — Posted on 2023-01-10

3029 Systematic elucidation of genetic mechanisms underlying cholesterol uptake

Hamilton, M. C.; Fife, J. D.; Akinci, E.; Yu, T.; Khowpinitchai, B.; Cha, M.; Barkal, S.; Thi, T. T.; Yeo, G.; Ramos Barroso, J. P.; Francoeur, M. J.; Velimirovic, M.; Gifford, D. K.; Lettre, G.; Yu, H.; Cassa, C. A.; Sherwood, R. I.

10.1101/2023.01.09.500804 — genetics — Posted on 2023-01-10

3030 Spatial transcriptomics reveals a conserved segment polarity program that governs muscle patterning in Nematostella vectensis

He, S.; Shao, W.; Chen, S.; Wang, T.; Gibson, M.

10.1101/2023.01.09.523347 — evolutionary biology — Posted on 2023-01-10

3031 Evolutionary history of the Brachyury gene in Hydrozoa: duplications, divergence and neofunctionalization.

Vetrova, A. A.; Kupaeva, D. M.; Lebedeva, T. S.; Walentek, P.; Tsikolia, N.; Kremnyov, S. V.

10.1101/2023.01.09.523299 — developmental biology — Posted on 2023-01-10

3032 Inducible in vivo genome editing in the sea star Patiria miniata

Zueva, O.; Hinman, V.

10.1101/2023.01.09.523328 — developmental biology — Posted on 2023-01-10

3033 CTCF is essential for proper mitotic spindle structure and anaphase segregation

Chiu, K.; Berrada, Y.; Eskndir, N.; Song, D.; Fong, C.; Naughton, S.; Chen, T.; Moy, S.; Gyurmey, S.; James, L.; Ezeiruaku, C.; Capistran, C.; Lowey, D.; Diwanji, V.; Peterson, S.; Parakh, H.; Burgess, A.; Probert, C.; Zhu, A.; Anderson, B.; Levi, N.; Gerlitz, G.; Packard, M. C.; Dorfman, K. A.; Bahiru, M. S.; Stephens, A. D.

10.1101/2023.01.09.523293 — cell biology — Posted on 2023-01-10

3034 Identification and Characterization of a Novel Major Facilitator Superfamily (MFS) Efflux Pump SA09310 Mediating Tetracycline Resistance in Staphylococcus aureus

Li, D.; Ge, Y.; Wang, N.; Shi, Y.; Guo, G.; Zou, Q.; Liu, Q.

10.1101/2023.01.09.523367 — microbiology — Posted on 2023-01-10

3035 Activation of basal forebrain astrocytes induces wakefulness without compensatory changes in sleep drive

Ingiosi, A. M.; Hayworth, C. R.; Frank, M. G.

10.1101/2023.01.09.523360 — neuroscience — Posted on 2023-01-10

3036 Genetic architecture of the white matter connectome of the human brain

Sha, Z.; Schijven, D.; Fisher, S. E.; Francks, C.

10.1101/2022.05.10.491289 — neuroscience — Posted on 2023-01-10

3037 Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

Dhavale, D. D.; Barclay, A. M.; Borcik, C. G.; Basore, K.; Gordon, I. R.; Liu, J.; Milchberg, M. H.; O'Shea, J. Y.; Rau, M. J.; Smith, Z.; Sen, S.; Summers, B.; Smith, J. W.; Warmuth, O. A.; Chen, Q.; Fitzpatrick, J. A. J.; Schwieters, C. D.; Tajkhorshid, E.; Rienstra, C. M.; Kotzbauer, P. T.

10.1101/2023.01.09.523303 — neuroscience — Posted on 2023-01-10

3038 Periplasmic stress contributes to a tradeoff between protein secretion and cell growth in E. Coli Nissile

Emani, S. S.; Kan, A. S.; Storms, T.; Bonanno, S.; Law, J.; Ray, S.; Joshi, N. S.

10.1101/2023.01.09.523330 — synthetic biology — Posted on 2023-01-10

3039 HYENA detects non-coding genes activated by distal enhancers in cancer

Yesilkanal, A. E.; Yu, A.; Thakur, A.; Wang, F.; Wu, X.; Muir, A.; He, X.; Spitz, F.; Yang, L.

10.1101/2023.01.09.523321 — cancer biology — Posted on 2023-01-10

3040 Dynamical modelling of proliferative-invasive plasticity and IFN-gamma signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity

Subhadarshini, S.; Sahoo, S.; Somarelli, J.; Jolly, M. K.

10.1101/2023.01.09.523355 — cancer biology — Posted on 2023-01-10

3041 Native Triboelectric Nanogenerator Ion Mobility-Mass Spectrometry of Egg Proteins Relevant to Objects of Cultural Heritage at Picoliter and Nanomolar Quantities.

Vallejo, D. D.; Popowich, A.; Arslanoglu, J.; Tokarski, C.; Fernandez, F.

10.1101/2023.01.09.523258 — biophysics — Posted on 2023-01-10

3042 DNA-origami line-actants control domain organisation and fission in synthetic membranes

Rubio-Sanchez, R.; Cicuta, P.; Mognetti, B. M.; Di Michele, L.

10.1101/2023.01.09.523307 — biophysics — Posted on 2023-01-10

3043 A multi-scale clutch model for adhesion complex mechanics

Venturini, C.; Saez, P.

10.1101/2023.01.09.523273 — biophysics — Posted on 2023-01-10

3044 13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue

Barclay, A. M.; Dhavale, D. D.; Borcik, C. G.; Milchberg, M. H.; Kotzbauer, P. T.; Rienstra, C. M.

10.1101/2023.01.09.523339 — biophysics — Posted on 2023-01-10

3045 Merging Bioactivity Predictions from Cell Morphology and Chemical Fingerprint Models by Leveraging Similarity to Training Data

Seal, S.; Yang, H.; Trapotsi, M.-A.; Singh, S.; Carreras-Puigvert, J.; Spjuth, O.; Bender, A.

10.1101/2022.08.11.503624 — bioinformatics — Posted on 2023-01-10

3046 CrossTx: Cross-cell line Transcriptomic Signature Predictions

Chrysinas, P.; Chen, C.; Gunawan, R.

10.1101/2023.01.09.523287 — bioinformatics — Posted on 2023-01-10

3047 AngioMT: An in silico platform for digital sensing of oxygen transport through heterogenous microvascular networks

Mathur, T.; Tronolone, J. J.; Jain, A.

10.1101/2023.01.09.523275 — bioengineering — Posted on 2023-01-10

3048 Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

Bai, N.; Adeshina, Y.; Bychkov, I.; Xia, Y.; Gowthaman, R.; Miller, S. A.; Gupta, A. K.; Johnson, D. K.; Lan, L.; Golemis, E. A.; Makhov, P. B.; Xu, L.; Pillai, M. M.; Boumber, Y.; Karanicolas, J.

10.1101/2023.01.09.523326 — biochemistry — Posted on 2023-01-10

3049 Multiplexed Methylated DNA Immunoprecipitation Sequencing (Mx-MeDIP-Seq) to Study DNA Methylation Using Low Amounts of DNA

Ridha, I.; Xu, C.; Chung, Y.; Park, J.; LaBaer, J.; Murugan, V.

10.1101/2023.01.09.523163 — genomics — Posted on 2023-01-10

3050 Evolutionary transcriptomics reveals longevity mostly driven by polygenic and indirect selection in mammals

Liu, W.; Zhu, P.; Li, M.; Li, Z.; Yu, Y.; Liu, G.; Du, J.; Wang, X.; Yang, J.; Tian, R.; Seim, I.; Kaya, A.; Li, M.; Li, M.; Gladyshev, V. N.; Zhou, X.

10.1101/2023.01.09.523139 — evolutionary biology — Posted on 2023-01-10

3051 SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

Aloise, C.; Schipper, J. G.; van Vliet, A.; Oymans, J.; Donselaar, T.; Hurdiss, D. L.; de Groot, R. J.; van Kuppeveld, F. J. M.

10.1101/2022.09.02.506332 — microbiology — Posted on 2023-01-10

3052 Humanized CD36 mouse model supports the preclinical evaluation of therapeutic candidates targeting CD36

Xie, X.; Niu, Z.; Wang, L.; Zhou, X.; Yu, X.; Jing, H.; Yang, Y.

10.1101/2023.01.09.523279 — immunology — Posted on 2023-01-10

3053 Peripersonal encoding of forelimb proprioception in the mouse somatosensory cortex

Alonso, I.; Scheer, I.; Palacio-Manzano, M.; Frezel-Jacob, N.; Philippides, A.; Prsa, M.

10.1101/2022.05.25.493376 — neuroscience — Posted on 2023-01-10

3054 Hamsters are a model for post-COVID-19 alveolar regeneration mechanisms: an opportunity to understand post-acute sequelae of SARS-CoV-2

Heydemann, L.; Ciurkiewicz, M.; Beythien, G.; Becker, K.; Schughart, K.; Stanelle-Bertram, S.; Schaumburg, B.; Mounogou-Kouassi, N.; Beck, S.; Zickler, M.; Kuehnel, M.; Gabriel, G.; Beineke, A.; Baumgaertner, W.; Armando, F.

10.1101/2022.11.17.515635 — pathology — Posted on 2023-01-10

3055 Oncogene-like addiction to aneuploidy in human cancers

Girish, V.; Lakhani, A. A.; Scaduto, C. M.; Thompson, S. L.; Brown, L. M.; Hagenson, R. A.; Sausville, E. L.; Mendelson, B. E.; Lukow, D. A.; Yuan, M. L.; Kandikuppa, P. K.; Stevens, E. C.; Lee, S. N.; Salovska, B.; Li, W.; Smith, J. C.; Taylor, A. M.; Martienssen, R. A.; Liu, Y.; Sun, R.; Sheltzer, J. M.

10.1101/2023.01.09.523344 — cancer biology — Posted on 2023-01-10

3056 Coexistence between similar invaders: The case of two cosmopolitan exotic insects

Arnold, M. B.; Back, M.; Crowell, M. D.; Farooq, N.; Ghimire, P.; Obarein, O. A.; Smart, K. E.; Taucher, T.; VanderJeugdt, E.; Perry, K. I.; Landis, D. A.; Bahlai, C.

10.1101/2022.02.03.479030 — ecology — Posted on 2023-01-10

3057 Six3 acts independently of Pax6 to provide an essential contribution to lens development

Grainger, R. M.; Fisher, M.; Nakayama, T.; Manohar, S.

10.1101/2023.01.09.523289 — developmental biology — Posted on 2023-01-10

3058 The neurodevelopmental transcriptome of the Drosophila melanogaster microcephaly gene abnormal spindle reveals a role for temporal transcription factors and the immune system in regulating brain size

Mannino, M. C.; Cassidy, M. B.; Florez, S.; Rusan, Z.; Chakraborty, S.; Schoborg, T.

10.1101/2023.01.09.523369 — developmental biology — Posted on 2023-01-10

3059 Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier

Baringer, S. L.; Palsa, K.; Simpson, I. A.; Connor, J. R.

10.1101/2023.01.10.522344 — cell biology — Posted on 2023-01-10

3060 N-Cadherin and alpha-catenin regulate formation of functional tunneling nanotubes

Pepe, A.; Notario Manzano, R.; Sartori-Rupp, A.; Brou, C.; Zurzolo, C.

10.1101/2023.01.10.523392 — cell biology — Posted on 2023-01-10

3061 A mechanism of melanogenesis mediated by E-cadherin downregulation and its involvement in solar lentigines

Inoue, D.; Narita, T.; Ishikawa, K.; Maeno, K.; Motoyama, A.; Ono, T.; Aoki, H.; Shibata, T.

10.1101/2023.01.09.523359 — cell biology — Posted on 2023-01-10

3062 Genome wide-analysis of anterior-posterior mRNA localization in Stentor coeruleus reveals a role for the microtubule cytoskeleton

Albright, A. R.; Angeles-Albores, D.; Marshall, W. F.

10.1101/2023.01.09.523364 — cell biology — Posted on 2023-01-10

3063 LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

Busley, A. V.; Gutierrez-Gutierrez, O.; Hammer, E.; Steinegger, M.; Boehmer, L.; Schroeder, H.; Kleinsorge, M.; Altmueller, J.; Marbach, F.; Hasenfuss, G.; Zimmermann, W.-H.; Wollnik, B.; Cyganek, L.

10.1101/2023.01.10.523203 — cell biology — Posted on 2023-01-10

3064 Polyploid yeast are dependent on elevated levels of Mps1 for successful chromosome segregation

Meyer, R. E.; Sartin, A.; Gish, M.; Harsha, J.; Wilkie, E.; Haworth, D.; LaVictorie, R.; Alberola, I.; Chuong, H. H.; Gorbsky, G. J.; Dawson, D. S.

10.1101/2023.01.09.523325 — cell biology — Posted on 2023-01-10

3065 Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1Omicron

Chen, D.-Y.; Kenney, D.; Chin, C.-V.; Tavares, A. H.; Khan, N.; Conway, H. L.; Liu, G.; Choudhary, M. C.; Gertje, H. P.; O'Connell, A. K.; Kotton, D. N.; Herrmann, A.; Ensser, A.; Connor, J. H.; Bosmann, M.; Li, J. Z.; Gack, M. U.; Baker, S. C.; Kirchdoerfer, R. N.; Kataria, Y.; Crossland, N. A.; Douam, F.; Saeed, M.

10.1101/2022.10.13.512134 — microbiology — Posted on 2023-01-10

3066 Neural phoneme discrimination in variable speech in newborns; associations with dyslexia risk and later language skills

Virtala, P.; Kujala, T.; Partanen, E.; Hamalainen, J. A.; Winkler, I.

10.1101/2023.01.10.522962 — neuroscience — Posted on 2023-01-10

3067 Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis

del Puerto, A.; Marti-Prado, B.; Barrios-Munoz, A. L.; Lopez-Fonseca, C.; Pose-Utrilla, J.; Alcover-Sanchez, B.; Cesca, F.; Schiavo, G.; Campanero, M. R.; Farinas, I.; Iglesias, T.; Porlan, E.

10.1101/2023.01.10.523252 — neuroscience — Posted on 2023-01-10

3068 A class-specific effect of dysmyelination on the excitability of hippocampal interneurons

Pinatel, D.; Pearlstein, E.; Bonetto, G.; Goutebroze, L.; Karagogeos, D.; Crepel, V.; Faivre-Sarrailh, C.

10.1101/2023.01.10.523413 — neuroscience — Posted on 2023-01-10

3069 The Myb family genes in the rice pathogen Magnaporthe oryzae: Finding and deleting more family members involved in pathogenicity

Li, Y.; Zheng, X.; Pei, M.; Chen, M.; Zhang, S.; Liang, C.; Gao, L.; Huang, P.; Olsson, S.

10.1101/2021.12.28.474317 — microbiology — Posted on 2023-01-10

3070 Trabecular bone remodeling in the ageing mouse: a micro-multiphysics agent-based in silico model using single-cell mechanomics

Boaretti, D.; Marques, F. C.; Ledoux, C.; Singh, A.; Kendall, J. J.; Wehrle, E.; Kuhn, G. A.; Bansod, Y. D.; Schulte, F.; Müller, R.

10.1101/2022.11.16.516723 — bioengineering — Posted on 2023-01-10

3071 The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

Sagert, L.; Winter, C.; Ruppert, I.; Zehetmaier, M.; Thomas, C.; Tampe, R.

10.1101/2023.01.08.523166 — biochemistry — Posted on 2023-01-10

3072 Purging due to self-fertilization does not prevent accumulation of expansion load

Zeitler, L.; Parisod, C.; Gilbert, K. J.

10.1101/2022.12.19.521096 — evolutionary biology — Posted on 2023-01-10

3073 Novel artificial selection method improves function of simulated microbial communities

Vessman, B.; Guridi-Fernandez, P.; Arias-Sanchez, F. I.; Mitri, S.

10.1101/2023.01.08.523165 — evolutionary biology — Posted on 2023-01-10

3074 A tissue dissociation method optimized for ATAC-seq and CUT&RUN in Drosophila pupal tissues.

Buchert, E. M.; Fogarty, E. A.; Uyehara, C. M.; McKay, D. J.; Buttitta, L.

10.1101/2022.08.15.504052 — developmental biology — Posted on 2023-01-10

3075 Localized modulation of DNA supercoiling, triggered by the Shigella anti-silencer VirB, is sufficient to relieve H-NS-mediated silencing

Picker, M. A.; Karney, M. M.; Gerson, T. M.; Karabachev, A. D.; Duhart, J. C.; McKenna, J. A.; Wing, H. J.

10.1101/2023.01.09.523335 — molecular biology — Posted on 2023-01-10

3076 CXCL13 levels in cerebrospinal fluids of patients with multiple sclerosis: The role of Borrelia proteins in neuro infections

Karabork, S.; Turkoglu, S. A.; Yıldız, S.; Sırmatel, F.

10.1101/2023.01.05.522966 — microbiology — Posted on 2023-01-10

3077 Calcium signals tune AMPK activity and mitochondrial homeostasis in dendrites of developing neurons

Hatsuda, A.; Kurisu, J.; Fujishima, K.; Kawaguchi, A.; Ohno, N.; Kengaku, M.

10.1101/2022.12.27.521995 — neuroscience — Posted on 2023-01-10

3078 Targeted gene deletion with SpCas9 and multiple guide RNAs in Arabidopsis thaliana: four are better than two

Ordon, J.; Kiel, N.; Becker, D.; Kretschmer, C.; Schulze-Lefert, P.; Stuttmann, J.

10.1101/2023.01.10.523375 — plant biology — Posted on 2023-01-10

3079 Cellular segregation in co-cultures driven by differential adhesion and contractility on distinct time scales

Skamrahl, M.; Schuenemann, J.; Mukenhirn, M.; Pang, H.; Gottwald, J.; Jipp, M.; Ferle, M.; Ruebeling, A.; Oswald, T. A.; Honigmann, A.; Janshoff, A.

10.1101/2022.05.23.492966 — biophysics — Posted on 2023-01-10

3080 MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio High Fidelity reads

Uliano-Silva, M.; Gabriel R. N. Ferreira, J.; Krasheninnikova, K.; Darwin Tree of Life Consortium, ; Formenti, G.; Abueg, L.; Torrance, J.; W Myers, G.; Durbin, R.; Blaxter, M.; A. McCarthy, S.

10.1101/2022.12.23.521667 — bioinformatics — Posted on 2023-01-10

3081 Aclarubicin stimulates RNA polymerase II elongation at closely spaced divergent promoters

Wooten, M.; Takushi, B.; Ahmad, K.; Henikoff, S.

10.1101/2023.01.09.523323 — genomics — Posted on 2023-01-10

3082 A field-capable rapid plant DNA extraction protocol using microneedle patches for botanical survey and monitoring

Selz, J.; Adam, N. R.; Magrini, C. E. M.; Montandon, F. M.; Buerki, S.; Maerkl, S. J.

10.1101/2023.01.09.523204 — ecology — Posted on 2023-01-10

3083 Ribonucleoprotein condensation driven by retrotransposon LINE-1 sustains RNA integrity and translation in mouse spermatocytes

De Luca, C.; Gupta, A.; Bortvin, A.

10.1101/2023.01.09.523313 — molecular biology — Posted on 2023-01-10

3084 Heterologous production of cyanophycin with Tatumella morbirosei cyanophycin synthetase

Swain, K.; Sharon, I.; Blackson, W.; Tekel, S.; Schmeing, T. M.; Nielsen, D. R.; Nannenga, B. L.

10.1101/2023.01.09.523336 — molecular biology — Posted on 2023-01-10

3085 Multifaceted roles of a light-responsive factor LhWRKY44 in promoting anthocyanin accumulation in Asiatic hybrid lilies (Lilium spp.)

Bi, M.; Liang, R.; Qu, Y.; Wang, J.; Cao, Y.; Liu, X.; He, G.; Zhang, W.; Yang, Y.; Tang, Y.; Yang, P.; Xu, L.; Ming, J.

10.1101/2023.01.09.523317 — molecular biology — Posted on 2023-01-10

3086 Tomato brown rugose fruit virus Mo gene is a novel microbial source tracking marker

Natarajan, A.; Fremin, B. J.; Schmidtke, D. T.; Wolfe, M.; Zlitni, S.; Graham, K. E.; Brooks, E. F.; Severyn, C. J.; Sakamoto, K. M.; Lacayo, N. J.; Kuersten, S.; Koble, J.; Caves, G.; Kaplan, I.; Singh, U.; Jagannathan, P.; Rezvani, A. R.; Bhatt, A. S.; Boehm, A. B.

10.1101/2023.01.09.523366 — microbiology — Posted on 2023-01-10

3087 To be or not to be an anti-CRISPR: AcrIII-1 and the importance of working with native biological systems

Martinez-Alvarez, L.; Stickel, D.; Salegi-Diez, A.; Bhoobalan-Chitty, Y.; Peng, X.

10.1101/2023.01.10.523387 — microbiology — Posted on 2023-01-10

3088 Metagenomic Data Reveal Type I Polyketide Synthase Distributions Across Biomes

Singh, H. W.; Creamer, K. E.; Chase, A. B.; Klau, L. J.; Podell, S.; Jensen, P. R.

10.1101/2023.01.09.523365 — microbiology — Posted on 2023-01-10

3089 Major trends and environmental correlates of spatiotemporal shifts in the distribution of genes compared to a biogeochemical model simulation in the Chesapeake Bay

Preheim, S. P.; Morris, S.; Zhang, Y.; Holder, C.; Arora-Williams, K.; Gensbigler, P.; Hinton, A.; Jin, R.; Pradal, M.-A.; Gnanadesikan, A.

10.1101/2023.01.09.523340 — microbiology — Posted on 2023-01-10

3090 The potato resistance protein Rx1 multimerizes upon activation by the Coat Protein of PVX

Knip, M.; Latul, E.; Takken, F. L.

10.1101/2023.01.10.523371 — plant biology — Posted on 2023-01-10

3091 Modular transcriptional responses to environmental changes

BERINGER, M.; Mattam, B.; CHOUDHURY, R. R.; Parisod, C.

10.1101/2023.01.09.523218 — plant biology — Posted on 2023-01-10

3092 Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex

Asko, O.; Blenkmann, A. O.; Leske, S. L.; Foldal, M. D.; Llorens, A.; Funderud, I.; Meling, T. R.; Knight, R. T.; Endestad, T.; Solbakk, A.-K.

10.1101/2023.01.04.521570 — neuroscience — Posted on 2023-01-10

3093 Expected Distractor Context Biases the Attentional Template for Target Shapes

Lerebourg, M.; de Lange, F. P.; Peelen, M. V.

10.1101/2022.10.18.512686 — neuroscience — Posted on 2023-01-10

3094 Cyclic di-AMP traps proton-coupled K+ transporters of the KUP family in an inward-occluded conformation

Fuss, M. F.; Wieferig, J.-P.; Corey, R. A.; Hellmich, Y.; Tascon, I.; Sousa, J. S.; Stansfeld, P. J.; Vonck, J.; Hänelt, I.

10.1101/2023.01.09.523207 — biophysics — Posted on 2023-01-10

3095 Competitive, connective and allosteric Nanobodies that modulate the SOS1-RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design

Fischer, B.; Uchanski, T.; Sheryazdanova, A.; Gonzalez, S.; Volkov, A. N.; Brosens, E.; Zogg, T.; Kalichuk, V. V.; Ballet, S.; Versees, W.; Sablina, A. A.; Pardon, E.; Wohlkonig, A.; Steyaert, J.

10.1101/2022.12.06.519258 — bioengineering — Posted on 2023-01-10

3096 Quantification of bacterial DNA in blood using droplet digital PCR: a pilot study

Tedim, A. P.; Merino, I.; Ortega, A.; Dominguez-Gil, M.; Eiros, J. M.; Bermejo-Martin, J. F.

10.1101/2022.12.02.518639 — microbiology — Posted on 2023-01-10

3097 Cumulative multisensory discrepancies shape the ventriloquism aftereffect but not the ventriloquism bias

Kayser, C.; Park, H.; Heuer, H.

10.1101/2022.09.06.506717 — neuroscience — Posted on 2023-01-10

3098 Eccentric cycling involves greater mental demand and cortical activation of the frontoparietal network

Borot, L.; Pageaux, B.; Laroche, D.; Vergotte, G.; Lepers, R.; Perrey, S.

10.1101/2022.11.05.515299 — physiology — Posted on 2023-01-10

3099 Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination

Myllymaki, H.; Kelly, L.; Elliot, A. M.; Carter, R. N.; Morton, N. M.; Feng, Y.

10.1101/2023.01.09.523333 — cancer biology — Posted on 2023-01-10

3100 Assessing the burden of rare DNA methylation outliers in schizophrenia

Hansen, C. S.; McQuillin, A.; St Claire, D.; Mill, J.; Hannon, E.; Sharp, A. J.; Janecka, M.

10.1101/2023.01.09.523073 — genetics — Posted on 2023-01-10

3101 Ecological and life history drivers of avian skull evolution

Hunt, E. S. E.; Felice, R. N.; Tobias, J. A.; Goswami, A.

10.1101/2023.01.09.523311 — evolutionary biology — Posted on 2023-01-10

3102 Phosphatidylinositol-4-phosphate signaling regulates dense granule biogenesis and exocytosis in Toxoplasma gondii

Arabiatorre, A.; Formanowicz, M.; Bankaitis, V. A.; Grabon, A.

10.1101/2023.01.09.523261 — cell biology — Posted on 2023-01-09

3103 Taxonomic identification accuracy from BOLD and GenBank databases using over a thousand insect barcodes from Colombia

Baena-Bejarano, N.; Reina, C.; Martinez-Revelo, D. E.; Medina, C. A.; Tovar, E.; Uribe-Soto, S.; Neita-Moreno, J. C.; Gonzalez, M. A.

10.1101/2022.10.26.513939 — molecular biology — Posted on 2023-01-09

3104 DNA G-quadruplex is a transcriptional control device that regulates memory

Marshall, P. R.; Zhao, Q.; Davies, J.; Liau, W.-S.; Lee, Y.; Basic, D.; Periyakaruppiah, A.; Zajaczkowski, E.; Leighton, L. J.; Madugalle, S. U.; Musgrove, M.; Kielar, M.; Gong, H.; Ren, H.; Kaczmarczyk, L.; Jackson, W. S.; Chen, A.; Spitale, R.; Bredy, T.

10.1101/2023.01.09.523337 — neuroscience — Posted on 2023-01-10

3105 Curation of causal interactions mediated by genes associated to autism accelerates the understanding of gene-phenotype relationships underlying neurodevelopmental disorders

Iannuccelli, M.; Vitriolo, A.; Licata, L.; Cheroni, C.; Castagnoli, L.; Testa, G.; Cesareni, G.; Perfetto, L.

10.1101/2023.01.09.523265 — systems biology — Posted on 2023-01-09

3106 Genomes of the human filarial parasites Mansonella perstans and Mansonella ozzardi

Sinha, A.; Li, Z.; Poole, C. B.; Morgan, R. D.; Ettwiller, L.; Lima, N. F.; Ferreira, M. U.; Fombad, F. F.; Wanji, S.; Carlow, C. K. S.

10.1101/2023.01.06.523030 — genomics — Posted on 2023-01-09

3107 Adaptive diversification and niche packing on rugged fitness landscapes

Rubin, I. N.; Ispolatov, Y.; Doebeli, M.

10.1101/2022.05.15.492034 — evolutionary biology — Posted on 2023-01-09

3108 Enzymatic reactions of AGO4 in RNA-directed DNA methylation: siRNA duplex loading, passenger strand elimination, target RNA slicing and sliced target retention

Wang, F.; Huang, H.-Y.; Huang, J.; Singh, J.; Pikaard, C. S.

10.1101/2022.10.06.511223 — molecular biology — Posted on 2023-01-09

3109 SIR telomere silencing depends on nuclear envelope lipids and modulates sensitivity to a lysolipid drug

sosa ponce, M. L.; Remedios, M. H.; Moradi Fard, S.; Cobb, J. A.; Zaremberg, V.

10.1101/2022.07.08.499406 — molecular biology — Posted on 2023-01-09

3110 Brain-localized CD4 and CD8 T cells perform correlated random walks and not Levy walks

Patel, D.; Lin, R.; Majumder, B.; Ganusov, V. V.

10.1101/2023.01.09.523257 — immunology — Posted on 2023-01-09

3111 Thalamocortical interactions shape hierarchical neural variability during stimulus perception

Tauste Campo, A.; Zainos, A.; Vazquez, Y.; Alvarez, M.; Deco, G.; Romo, R.; Rossi Pool, R.

10.1101/2022.09.20.508691 — neuroscience — Posted on 2023-01-09

3112 Anti-seizure Gene Therapy for Focal Cortical Dysplasia

Almacellas Barbanoj, A.; Graham, R. T.; Maffei, B.; Carpenter, J. C.; Leite, M.; Hoke, J.; Hardjo, F.; Scott-Solache, J.; Chimonides, C.; Schorge, S.; Kullmann, D. M.; Magloire, V.; Lignani, G.

10.1101/2023.01.09.523292 — neuroscience — Posted on 2023-01-09

3113 Single-nucleus transcriptional profiling of GAD2-positive neurons from mouse lateral habenula reveals distinct expression of neurotransmission- and depression-related genes

Green, M. V.; Gallegos, D. A.; Boua, J.-V.; Bartelt, L. C.; Narayanan, A.; West, A. E.

10.1101/2023.01.09.523312 — neuroscience — Posted on 2023-01-09

3114 Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia

Hoq, M. R.; Bharath, S.; Hallinan, G.; Fernandez, A.; Vago, F.; Ozcan, K.; Li, D.; Garringer, H.; Vidal, R.; Ghetti, B.; Jiang, W.

10.1101/2023.01.09.523314 — neuroscience — Posted on 2023-01-09

3115 A comparative analysis of microglial inducible Cre lines

Faust, T. E.; Feinberg, P. A.; O'Connor, C.; Kawaguchi, R.; Chan, A.; Strasburger, H.; Masuda, T.; Amann, L.; Knobeloch, K.-P. E.; Prinz, M.; Schaefer, A.; Schafer, D. P.

10.1101/2023.01.09.523268 — neuroscience — Posted on 2023-01-09

3116 DANCE: A Deep Learning Library and Benchmark Platform for Single-Cell Analysis

Ding, J.; Wen, H.; Tang, W.; Liu, R.; Li, Z.; Venegas, J.; Su, R.; Molho, D.; Jin, W.; Zuo, W.; Wang, Y.; Yang, R.; Xie, Y.; Tang, J.

10.1101/2022.10.19.512741 — bioinformatics — Posted on 2023-01-09

3117 SNV-FEAST: microbial source tracking with single nucleotide variants

Briscoe, L.; Halperin, E.; Garud, N. R.

10.1101/2022.05.28.493810 — bioinformatics — Posted on 2023-01-09

3118 CeLab, a Microfluidic Platform for the Study of Life History Traits, reveals Metformin and SGK-1 regulation of Longevity and Reproductive Span

Sohrabi, S.; Cota, V.; Murphy, C. T.

10.1101/2023.01.09.523184 — bioengineering — Posted on 2023-01-09

3119 Fast and Accurate Cell Tracking: a real-time cell segmentation and tracking algorithm to instantly export quantifiable cellular characteristics from large scale image data

Chou, T.-C.; You, L.; Beerens, C.; Feller, K. J.; Chien, M.-P.

10.1101/2023.01.09.523224 — bioengineering — Posted on 2023-01-09

3120 Hypothalamic Protein Profiling from Mice Subjected to Social Defeat Stress

Mitra, S.; Sameer Kumar, G. S.; Samanta, A.; Thakur, S. S.

10.1101/2023.01.09.523315 — animal behavior and cognition — Posted on 2023-01-09

3121 Beyond mean fitness: demographic stochasticity and resilience matter at tree species climatic edges

Guyennon, A.; Reineking, B.; Salguero-Gomez, R.; Dahlgren, J.; Lehtonen, A.; Ratcliffe, S.; Ruiz-Benito, P.; Zavala, M. A.; Kunstler, G.

10.1101/2022.08.22.504487 — ecology — Posted on 2023-01-09

3122 Efficient decision-makers evaluate relative reward per effort

Kubanek, J.

10.1101/2022.05.31.494175 — ecology — Posted on 2023-01-09

3123 Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury

Ngo, A. T.; Sarkar, A.; Yarovoi, I.; Levine, N.; Bochenek, V.; Zhao, G.; Rauova, L.; Kowalska, M. A.; Eckart, K.; Mangalmurti, N.; Rux, A.; Cines, D. B.; Poncz, M.; Gollomp, K.

10.1101/2023.01.09.522931 — cell biology — Posted on 2023-01-09

3124 Loss of PTPMT1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure

Zheng, H.; Li, Q.; Li, S.; Li, Z.; Brotto, M.; Weiss, D.; Prosdocimo, D.; Xu, C.; Reddy, A.; Puchowicz, M.; Zhao, X.; Weitzmann, M. N.; Jain, M. K.; Qu, C.-K.

10.1101/2023.01.09.523031 — cell biology — Posted on 2023-01-09

3125 INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10

Zhang, W.; Zhao, J.; Deng, L.; Ishimwe, N.; Pauli, J.; Wu, W.; Shan, S.; Kempf, W.; Ballantyne, M. D.; Kim, D.; Lyu, Q.; Bennett, M.; Rodor, J.; Turner, A. W.; Lu, Y. W.; Gao, P.; Choi, M.; Warthi, G.; Kim, H. W.; Barroso, M. M.; Bryant, W. B.; Miller, C. L.; Weintraub, N. L.; Maegdefessel, L.; Miano, J. M.; Baker, A. H.; Long, X.

10.1101/2023.01.07.522948 — molecular biology — Posted on 2023-01-09

3126 A Binary RNA and DNA Self-Amplifying Platform for Next Generation Vaccines and Therapeutics

Jefferies, W.; Choi, K. B.; Ribeca, P.; Kari, S.; Young, J.; Hui, E.; Qi, S. Y.; Garrosvillas, E.; Lincez, P.; Welch, T.; Saranchova, I.; Pfeifer, C. G.

10.1101/2022.12.06.519322 — immunology — Posted on 2023-01-09

3127 Mapping multidimensional content representations to neural and behavioral expressions of episodic memory

Wang, Y.; Lee, H.; Kuhl, B. A.

10.1101/2023.01.09.523096 — neuroscience — Posted on 2023-01-09

3128 Functional Topography of the Neocortex Predicts Covariation in Complex Cognitive and Basic Motor Abilities

Whitman, E. T.; Knodt, A. R.; Elliott, M. L.; Abraham, W. C.; Cheyne, K.; Hogan, S.; Ireland, D.; Keenan, R.; Lueng, J. H.; Melzer, T. R.; Poulton, R.; Purdy, S. C.; Ramrakha, S.; Thorne, P. R.; Caspi, A.; Moffitt, T. E.; Hariri, A. R.

10.1101/2023.01.09.523297 — neuroscience — Posted on 2023-01-09

3129 Is high-frequency activity evidence of an anterior temporal lobe network or micro-saccades?

O'Neill, G. C.; Mellor, S.; Seymour, R. A.; Alexander, N.; Tierney, T. M.; Timms, R. C.; Maguire, E. A.; Barnes, G. R.

10.1101/2023.01.09.523285 — neuroscience — Posted on 2023-01-09

3130 Natural gradient enables fast sampling in spiking neural networks

Masset, P.; Zavatone-Veth, J. A.; Connor, J. P.; Murthy, V. N.; Pehlevan, C.

10.1101/2022.06.03.494680 — neuroscience — Posted on 2023-01-09

3131 Distinct Functional cerebral Hypersensitivity networks during incisional and inflammatory pain in rats

Kreitz, S.; Pradier, B.; Segelcke, D.; Amirmohseni, S.; Hess, A.; Faber, C.; Pogatzki-Zahn, E. M.

10.1101/2023.01.09.523228 — neuroscience — Posted on 2023-01-09

3132 Mapping the auditory space of Culex pipiens female mosquito in 3D

Lapshin, D.; Vorontsov, D.

10.1101/2023.01.09.523250 — neuroscience — Posted on 2023-01-09

3133 Early rise and persistent inhibition of electromyography during failed stopping

Fisher, M.; Trinh, H.; O'Neill, J.; Greenhouse, I.

10.1101/2023.01.09.523332 — neuroscience — Posted on 2023-01-09

3134 Multiplex qPCR assays for detection of two imperiled anuran species, Anaxyrus californicus and Spea hammondii, from environmental DNA

Rodgers, T. W.; Lovich, R. E.; Walton, J. A.; Prince, D. J.; Gonzales, B. R.; Shaffer, H. B.; Mock, K. E.

10.1101/2022.12.20.521282 — zoology — Posted on 2023-01-09

3135 At-home, cell-free synthetic biology education modules for transcriptional regulation and environmental water quality monitoring

Jung, K. J.; Rasor, B. J.; Rybnicky, G. A.; Silverman, A. D.; Standeven, J.; Kuhn, R.; Granito, T.; Ekas, H. M.; Wang, B. M.; Karim, A. S.; Lucks, J. B.; Jewett, M. C.

10.1101/2023.01.09.523248 — synthetic biology — Posted on 2023-01-09

3136 Insulin resistance-driven beta-cell adaptation in mice: Mechanistic characterization and 3D analysis

Liboz, A.; Beaupere, C.; Roblot, N.; Tinevez, J.-Y.; Guilmeau, S.; Burnol, A.-F.; Gueddouri, D.; Prieur, X.; Feve, B.; Guillemain, G.; Blondeau, B.

10.1101/2023.01.09.523222 — physiology — Posted on 2023-01-09

3137 Cyclic di-AMP traps proton-coupled K+ transporters of the KUP 1 family in an inward-occluded conformation

Fuss, M. F.; Wieferig, J.-P.; Corey, R. A.; Hellmich, Y.; Tascon, I.; Sousa, J. S.; Stansfeld, P. J.; Vonck, J.; Hanelt, I.

10.1101/2023.01.09.523207 — biophysics — Posted on 2023-01-09

3138 Integration of chromatin accessibility and gene expression data with cisREAD reveals a switch from PU.1/SPIB-driven to AP-1-driven gene regulation during B cell activation

Emmett, A. M. L.; Saadi, A.; Care, M. A.; Doody, G. M.; Tooze, R. M.; Westhead, D. R.

10.1101/2023.01.09.522862 — bioinformatics — Posted on 2023-01-09

3139 Robotics-driven manufacturing of cartilaginous microtissues for the bio-assembly of skeletal implants

Decoene, I.; Nasello, G.; Madeiro, R. F.; Nilsson Hall, G.; Pastore, A.; Van Hoven, I.; Ribeiro Viseu, S.; Verfaillie, C.; Geris, L.; Luyten, F.; Papantoniou, I.

10.1101/2023.01.09.522841 — bioengineering — Posted on 2023-01-09

3140 Dopamine and norepinephrine differentially mediate the exploration-exploitation tradeoff

Chen, C. S.; Mueller, D.; Knep, E.; Ebitz, R. B.; Grissom, N. M.

10.1101/2023.01.09.523322 — animal behavior and cognition — Posted on 2023-01-09

3141 Unique amino acid substitution in RBD region of SARS-CoV-2 Omicron XAY.2

Salsekar, L.; Rahangdale, S.; Tamboli, E.; Khairnar, K.

10.1101/2023.01.09.523246 — genomics — Posted on 2023-01-09

3142 High-dimensional phenotyping to define the genetic basis of cellular morphology

Tegtmeyer, M.; Arora, J.; Asgari, S.; Cimini, B. A.; Peirent, E.; Liyanage, D.; Way, G. P.; Weisbart, E.; Nathan, A.; Amariuta, T.; Eggan, K.; Haghighi, M.; McCarroll, S. A.; Carpenter, A. E.; Singh, S.; Nehme, R.; Raychaudhuri, S.

10.1101/2023.01.09.522731 — genomics — Posted on 2023-01-09

3143 Comparative genomics of smut fungi suggest the ability of meiosis and mating in asexual species of the genus Pseudozyma (Ustilaginales)

Steins, L.; Guerreiro, M. A.; Duhamel, M.; Liu, F.; Wang, Q.-M.; Boekhout, T.; Begerow, D.

10.1101/2023.01.09.523226 — genomics — Posted on 2023-01-09

3144 Decoding the genetic and chemical basis of sexual attractiveness in parasitic wasps

Sun, W.; Lange, M. I.; Gadau, J.; Buellesbach, J.

10.1101/2023.01.09.523239 — genetics — Posted on 2023-01-09

3145 Phylogenomics reveals pervasive ancient introgression in the radiation of macaques

Tan, X.; Qi, J.; Liu, Z.; Fan, P.; Zhang, L.; Li, J.; Roos, C.; Zhou, X.; Li, M.

10.1101/2023.01.09.523240 — evolutionary biology — Posted on 2023-01-09

3146 Parental care drives the evolution of molecular genetic variation

Mashoodh, R.; Trowsdale, A. T.; Manica, A.; Kilner, R. M.

10.1101/2023.01.09.523216 — evolutionary biology — Posted on 2023-01-09

3147 The Ecology of Viruses in Urban Rodents with a Focus on SARS-CoV-2

Fisher, A.; Airey, G.; Liu, Y.; Gemmell, M.; Thomas, J.; Bentley, E.; Whitehead, M.; Paxton, W.; Pollakis, G.; Paterson, S.; Viney, M.

10.1101/2023.01.07.523115 — ecology — Posted on 2023-01-09

3148 Bivalent mRNA vaccine improves antibody-mediated neutralization of many SARS-CoV-2 Omicron lineage variants

Jiang, N.; Wang, L.; Hatta, M.; Feng, C.; Currier, M.; Lin, X.; Hossain, J.; Cui, D.; Mann, B. R.; Kovacs, N. A.; Wang, W.; Atteberry, G.; Wilson, M.; Chau, R.; Lacek, K. A.; Paden, C. R.; Hassell, N.; Rambo-Martin, B.; Barnes, J. R.; Kondor, R. J.; Self, W. H.; Rhoads, J. P.; Baughman, A.; Chappell, J. D.; Shapiro, N. I.; Gibbs, K. W.; Hager, D. N.; Lauring, A. S.; Surie, D.; McMorrow, M. L.; Thornburg, N. J.; Wentworth, D. E.; Zhou, B.

10.1101/2023.01.08.523127 — microbiology — Posted on 2023-01-09

3149 Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single cell transcriptomics

Briggs, E. M.; Marques, C. A.; Oldrieve, G. R.; Hu, J.; Otto, T. D.; Matthews, K. D.

10.1101/2023.01.09.523263 — microbiology — Posted on 2023-01-09

3150 T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy

Hansen, A. S.; Jensen, L. S.; Ryttersgaard, K. G.; Krapp, C.; Just, J.; Gammelgaard, K. R.; Jonsson, K. L.; Johannsen, M.; Etzerodt, A.; Deleuran, B. W.; Jakobsen, M. R.

10.1101/2023.01.09.523220 — immunology — Posted on 2023-01-09

3151 Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model

Fei, N.; Miyoshi, S.; Hermanson, J. B.; Miyoshi, J.; Xie, B.; DeLeon, O.; Hawkins, M.; Charlton, W.; D'Souza, M.; Hart, J.; Sulakhe, D.; Martinez-Guryn, K. B.; Chang, E. B.; Charlton, M. R.; Leone, V. A.

10.1101/2023.01.09.523249 — physiology — Posted on 2023-01-09

3152 Terrestrial endotherms trade body temperature regulation for the stress response when energy is limited

Tabh, J. K. R.; Hartjes, M.; Burness, G.

10.1101/2023.01.09.523310 — physiology — Posted on 2023-01-09

3153 Effects of Variants of Concern Mutations on the Force-Stability of the SARS-CoV-2:ACE2 Interface and Virus Transmissibility

Bauer, M. S.; Gruber, S.; Hausch, A.; Melo, M. C. R.; Gomes, P. S. F. C.; Nicolaus, T.; Milles, L. F.; Bernardi, R. C.; Gaub, H. E.; Lipfert, J.

10.1101/2023.01.06.522349 — biophysics — Posted on 2023-01-09

3154 Force-regulated spontaneous conformational changes of integrins α5β1 and αVβ3

Chen, Y.; Kong, F.; Li, Z.; Ju, L. A.; Zhu, C.

10.1101/2023.01.09.523308 — biophysics — Posted on 2023-01-09

3155 Odd-even disparity in the population of slipped hairpins in RNA repeat sequences with implications for phase separation

Maity, H.; Nguyen, H. T.; Hori, N.; Thirumalai, D.

10.1101/2023.01.09.523227 — biophysics — Posted on 2023-01-09

3156 SemiBin2: self-supervised contrastive learning leads to better MAGs for short- and long-read sequencing

Pan, S.; Zhao, X.-M.; Coelho, L. P.

10.1101/2023.01.09.523201 — bioinformatics — Posted on 2023-01-09

3157 Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating JMJD3

Saiioum, Z.; Dauner, K.; Verma, N.; Zhang, D. J.; Nakka, K.; VALDIVIESO GONZALEZ, D.; Almendro-Vedia, V.; McDonald, J.; Lopez Montero, I.; Sorisky, A.; Dilworth, J.; Zha, X.

10.1101/2023.01.09.523264 — biochemistry — Posted on 2023-01-09

3158 Mutation rate, selection, and epistasis inferred from RNA virus haplotypes via neural posterior estimation

Caspi, I.; Meir, M.; Ben Nun, N.; Stern, A.; Ram, Y.

10.1101/2023.01.09.523230 — evolutionary biology — Posted on 2023-01-09

3159 Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern

10.1101/2023.01.09.523209 — microbiology — Posted on 2023-01-09

3160 An expert-based global assessment of threats and conservation measures for subterranean ecosystems

Nanni, V.; Piano, E.; Cardoso, P.; Isaia, M.; Mammola, S.

10.1101/2023.01.09.523190 — ecology — Posted on 2023-01-09

3161 Population-level interactions among PV, SOM, and Pyramidal neurons in cortex

Potter, C. T.; Bassi, C. D.; Runyan, C. A.

10.1101/2023.01.09.523298 — neuroscience — Posted on 2023-01-09

3162 Insights into the metabolic specificities of pathogenic strains from the Ralstonia solanacearum species complex

Baroukh, C.; Cottret, L.; Pires, E.; Peyraud, R.; Guidot, A.; Genin, S.

10.1101/2023.01.09.523232 — systems biology — Posted on 2023-01-09

3163 Direct visualization of emergent metastatic features within an ex vivo model of the tumor microenvironment

Anandi, L.; Garcia, J.; Janska, L.; Liu, J.; Ros, M.; Carmona-Fontaine, C.

10.1101/2023.01.09.523294 — cancer biology — Posted on 2023-01-09

3164 HQAlign: Aligning nanopore reads for SV detection using current-level modeling

Joshi, D. J.; Diggavi, S. N.; Chaisson, M.; Kannan, S.

10.1101/2023.01.08.523172 — bioinformatics — Posted on 2023-01-09

3165 Predicting murine age across tissues and cell types using single cell transcriptome data

Neumann, J. F.; Leote, A. C. d. S.; Liersch, M.; Beyer, A.

10.1101/2022.10.19.512922 — bioinformatics — Posted on 2023-01-09

3166 A cinnamyl alcohol dehydrogenase (CAD) like enzyme leads to a branch in the shikonin biosynthetic pathway in Arnebia euchroma

Wang, R.; Liu, C.; Wang, S.; Sun, J.; Guo, J.; Lyu, C.; Kang, C.; Wan, X.; Shi, L.; Wang, J.; Huang, L.; guo, l.

10.1101/2023.01.09.523192 — biochemistry — Posted on 2023-01-09

3167 The influence of partner presence and association strength on neophobia in tokay geckos

Szabo, B.; Ringler, E.

10.1101/2023.01.09.523205 — animal behavior and cognition — Posted on 2023-01-09

3168 Genomes of the human filarial parasites Mansonella perstans and Mansonella ozzardi

Sinha, A.; Li, Z.; Poole, C. B.; Morgan, R. D.; Ettwiller, L.; Lima, N. F.; Ferreira, M. U.; Fombad, F. F.; Wanji, S.; Carlow, C. K. S.

10.1101/2023.01.06.523030 — genomics — Posted on 2023-01-09

3169 Genetics of Latin American Diversity (GLAD) Project: insights into population genetics and association studies in recently admixed groups in the Americas

Borda, V.; Loesch, D. P.; Guo, B.; Laboulaye, R.; Veliz-Otani, D.; French-Kwawu, J. N.; Peixoto Leal, T.; Gogarten, S. M.; Ikpe, S.; Gouveia, M. H.; Mendes, M.; Abecasis, G. R.; Alvim, I.; Arboleda-Bustos, C. E.; Arboleda, G.; Arboleda, H.; Barreto, M. L.; Barwick, L.; Bezzera, M. A.; Blangero, J.; Borges, V.; Caceres, O.; Cai, J.; Chana-Cuevas, P.; Chen, Z.; Custer, B.; Dean, M.; Dinardo, C.; Domingos, I.; Duggirala, R.; Dieguez, E.; Fernandez, W.; Ferraz, H. B.; Gilliland, F. D.; Guio, H.; Horta, B.; Curran, J. E.; Johnsen, J. M.; Kaplan, R. C.; Kelly, S.; Kenny, E. E.; Kittner, S.; Konkle,

10.1101/2023.01.07.522490 — genetics — Posted on 2023-01-09

3170 MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size

Lafferty, M. J.; Aygün, N.; Patel, N. K.; Krupa, O.; Liang, D.; Wolter, J. M.; Geschwind, D. H.; de la Torre-Ubieta, L.; Stein, J. L.

10.1101/2022.03.31.486585 — genetics — Posted on 2023-01-09

3171 A network based approach to identifying correlations between phylogeny, morphological traits and occurrence information of fish Species in US river basins.

Tripathi, R.; Reza, A.; Su, G.; Mertel, A.; Calabrese, J. M.

10.1101/2023.01.09.523236 — ecology — Posted on 2023-01-09

3172 Single-cell transcriptomic profiling redefines the origin and specification of early adrenogonadal progenitors

Neirijnck, Y.; Sararols, P.; Kuhne, F.; Mayere, C.; Nef, S.; Schedl, A.

10.1101/2023.01.09.523195 — developmental biology — Posted on 2023-01-09

3173 YAP-dependent autophagy is controlled by AMPK, SIRT1 and flow intensity in kidney epithelial cells.

Claude-Taupin, A.; Roccio, F.; Garfa-Traore, M.; Regnier, A.; Burtin, M.; Morel, E.; Terzi, F.; Codogno, P.; Dupont, N.

10.1101/2023.01.09.523237 — cell biology — Posted on 2023-01-09

3174 Chemical inhibition of bromodomain proteins in insect stage African trypanosomes perturbs silencing of the Variant Surface Glycoprotein repertoire and results in widespread changes in the transcriptome

Ashby, E. C.; Havens, J. L.; Hardin, J.; Schulz, D.

10.1101/2023.01.09.523188 — molecular biology — Posted on 2023-01-09

3175 Epigenetically silenced DACT3 promotes tumor growth via affecting Wnt/beta-catenin signaling and supports chidamide plus azacitidine therapy in acute myeloid leukemia

Jiang, D.; Shao, H.; Meng, J.; Mo, Q.; Zhong, R.; Ji, X.; Liang, C.; Lin, W.; Chen, F.; Dong, M.

10.1101/2023.01.09.523194 — molecular biology — Posted on 2023-01-09

3176 Composition of nasopharyngeal microbiota in individuals with SARS-CoV-2 infection across three COVID-19 waves in India

Bose, T.; Wasimuddin, ; Acharya, V.; Pinna, N. K.; Kaur, H.; Ranjan, M.; Jandhyala, S.; Nagabandi, T.; Varma, B.; Tallapaka, K. B.; Sowpati, D. T.; Haque, M. M.; Dutta, A.; Siva, A. B.; Mande, S. S.

10.1101/2023.01.02.522449 — microbiology — Posted on 2023-01-09

3177 The Effect of Growth Substrate Availability on Anaerobic Arsenic Methylation by Paraclostridium bifermentans strain EML

Qiao, J.; Sallet, H.; Meibom, K. L.; Jacquemin, N.; Bernier-Latmani, R.

10.1101/2023.01.09.523296 — microbiology — Posted on 2023-01-09

3178 The splicing isoform Foxpdelta2 releases the autoinhibitory conformation and differentially regulates tTregs and pTregs homeostasis

Qianchong, G.; Xiufeng, Z.; Jie, G.; Wei, X.; Jianhua, Z.; Wei, Z.; Fuping, Z.; Baidong, H.; Xuyu, Z.

10.1101/2023.01.09.523191 — immunology — Posted on 2023-01-09

3179 Loss of Rab8a in B cells leads to increased antibody responses and class-switch recombination

Hernandez-Perez, S.; Sarapulov, A. V.; Balci, M. O.; Coffey, E.; Harada, A.; Mattila, P.

10.1101/2022.09.19.508414 — immunology — Posted on 2023-01-09

3180 A Gamma-adapted recombinant subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection.

Coria, L. M.; Rodriguez, J. M.; Demaria, A.; Bruno, L. A.; Rios Medrano, M.; Pueblas Castro, C.; Castro, E. F.; Del Priore, S. A.; Hernando Insua, A. C.; Kaufmann, I. G.; Saposnik, L. M.; Stone, W. B.; Prado, L.; Krum, V.; Zurvarra, F. M.; Sidabra, J. E.; Drehe, I.; Baque, J. A.; Li Causi, M.; De Nichilo, A. V.; Payes, C. J.; Auguste, A. J.; Vega, J. C.; Alvarez, D. E.; Flo, J. M.; Pasquevich, K. A.; Cassataro, J.

10.1101/2023.01.03.522213 — immunology — Posted on 2023-01-09

3181 A Convolutional Autoencoder-based Explainable Clustering Approach for Resting-State EEG Analysis

Ellis, C. A.; Miller, R.; Calhoun, V.

10.1101/2023.01.04.522805 — neuroscience — Posted on 2023-01-09

3182 Acute psilocybin enhances cognitive flexibility in rats

Torrado Pacheco, A.; Olson, R. J.; Garza, G.; Moghaddam, B.

10.1101/2023.01.09.523291 — neuroscience — Posted on 2023-01-09

3183 Low Rate Hippocampal Delay Period Activity Encodes Behavioral Experience

Athanasiadis, M.; Masserini, S.; Yuan, L.; Fetterhoff, D.; Leutgeb, J. K.; Leutgeb, S.; Leibold, C.

10.1101/2023.01.09.523199 — neuroscience — Posted on 2023-01-09

3184 A shift in the mechanisms controlling hippocampal engram formation during brain maturation

Ramsaran, A. I.; Wang, Y.; Golbabaei, A.; Yeung, B.-r. A.; de Snoo, M. L.; Rashid, A. J.; Awasthi, A.; Lau, J.; Tran, L. M.; Ko, S. Y.; Abegg, A.; Duan, L. C.; McKenzie, C.; Gallucci, J.; Ahmed, M.; Kaushik, R.; Dityatev, A.; Josselyn, S. A.; Frankland, P. W.

10.1101/2023.01.09.523283 — neuroscience — Posted on 2023-01-09

3185 A Multiscale Protein Abundance Structured Population Kinetic Model Systematically Explores the Design Space of Constitutive and Inducible CAR-T cells

Das, J.; Rajakaruna, H.; Desai, M.

10.1101/2023.01.09.523295 — systems biology — Posted on 2023-01-09

3186 H2A.X mutants exhibit enhanced DNA demethylation in Arabidopsis thaliana

Frost, J. M.; Lee, J.; Hsieh, P.-H.; Lin, S. J.; Min, Y.; Bauer, M.; Runkel, A.; Cho, H.-T.; Hsieh, T.-F.; Choi, Y.; Fischer, R. L.

10.1101/2023.01.08.523178 — plant biology — Posted on 2023-01-09

3187 Changes in Plasma Fatty Acid Abundance Related to Chronic Pancreatitis: A Pilot Study

Gumpper, K.; Crowe, O.; Hart, P. A.; Pita-Grisanti, V.; Velez-Bonet, E.; Belury, M. A.; Ramsey, M.; Cole, R. M.; Badi, N.; Culp, S.; Hinton, A.; Lara, L.; Krishna, S. G.; Conwell, D. L.; Cruz-Monserrate, Z.

10.1101/2023.01.05.522899 — physiology — Posted on 2023-01-09

3188 Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

Voss, H. L.; Godbole, S.; Schlumbohm, S.; Schumann, Y.; Peng, B.; Mynarek, M.; Rutkowski, S.; Dottermusch, M.; Dorostkar, M.; Korshunov, A.; Mair, T.; Pfister, S.; Neumann, P.; Hartmann, C.; Weiss, J.; Liesche-Starnecker, F.; Yudong, G.; Schlueter, H.; Schueller, U.; Krisp, C.; Neumann, J. E.

10.1101/2023.01.09.523234 — cancer biology — Posted on 2023-01-09

3189 Simultaneous Determination of Size and Shape of Single alpha-Synuclein Oligomers in Solution

Awasthi, S.; Ying, C.; Li, J.; Mayer, M.

10.1101/2023.01.09.523202 — biophysics — Posted on 2023-01-09

3190 Improving prediction of drug-target interactions based on fusing multiple features with data balancing and feature selection techniques

Khojasteh, H.; Pirgazi, J.

10.1101/2022.12.07.519302 — bioinformatics — Posted on 2023-01-09

3191 Weakly-supervised temporal segmentation of cell-cycle stages with center-cell focus using Recurrent Neural Networks

Jose, A.; Roy, R.; Stegmaier, J.

10.1101/2023.01.09.523193 — bioinformatics — Posted on 2023-01-09

3192 Supramolecular fibrous hydrogel augmentation of uterosacral ligament suspension for treatment of pelvic organ prolapse

Miller, B.; Wolfe, W.; Gentry, J. L.; Grewal, M. G.; Highley, C. B.; De Vita, R.; Vaughan, M. H.; Caliari, S. R.

10.1101/2023.01.08.522930 — bioengineering — Posted on 2023-01-09

3193 Phage-Assisted, Active Site-Directed Ligand Evolution with a Genetically Encoded Nε-Butyryl-ʟ-Lysine to Identify a Cellularly Potent and Selective Inhibitor for the ENL YEATS Domain as an Anti-Leukemia Agent

Chen, P.-H. C.; Guo, X. S.; Zhang, H. E.; Geng, Z. Z.; Dubey, G. K.; Fierke, C. A.; Xu, S.; Liu, W. R.

10.1101/2023.01.08.523168 — biochemistry — Posted on 2023-01-09

3194 Structural insights into transcription activation mechanism of the global regulator GlnR from actinobacteria

Lin, W.; Shi, J.; Feng, Z.; Xu, J.; Li, F.; Zhang, Y.; Wen, A.; Wang, F.; Song, Q.; Wang, L.; Wang, S.; Feng, Y.

10.1101/2023.01.09.523197 — biochemistry — Posted on 2023-01-09

3195 A pilot study of stable isotope fractionation in Bombyx mori rearing

Li, H.; He, Y.; Lu, J.; Jia, L.; Liu, Y.; Yang, D.; Shao, S.; Lv, G.; Yang, H.; Zheng, H.; Cui, X.; Zhou, Y.; Peng, Z.

10.1101/2023.01.08.523185 — biochemistry — Posted on 2023-01-09

3196 Demonstration of in vivo engineered tandem duplications of varying sizes using CRISPR and recombinases in Drosophila melanogaster

Loehlin, D. W.; McClain, G. L.; Xu, M.; Kedia, R.; Root, E.

10.1101/2023.01.08.523181 — genetics — Posted on 2023-01-09

3197 Westwards expansion of the European catfish Silurus glanis in the Douro River (Portugal)

Gkenas, C.; Martelo, J.; Ribeiro, D.; Gago, J.; Santos, G.; Dias, D.; Ribeiro, F.

10.1101/2023.01.07.522915 — ecology — Posted on 2023-01-09

3198 Development of novel cytoprotective small compounds inhibiting mitochondria-dependent apoptosis

Matsuyama, S.; Matsuyama, M.; Ortega, J.; Fedorov, Y.; Scott-McKean, J.; Muller-Greven, J.; Buck, M.; Adams, D.; Jastrzebska, B.; Greenlee, W.

10.1101/2022.10.12.511987 — cell biology — Posted on 2023-01-09

3199 Acute effects of subanesthetic ketamine on cerebrovascular hemodynamics in humans: A TD-fNIRS neuroimaging study

Castillo, A.; Dubois, J.; Field, R. M.; Fishburn, F.; Gundran, A.; Ho, W. C.; Jawhar, S.; Kates-Harbeck, J.; M. Aghajan, Z.; Miller, N.; Perdue, K. L.; Phillips, J.; Ryan, W. C.; Shafiei, M.; Scholkmann, F.; Taylor, M.

10.1101/2023.01.06.522912 — neuroscience — Posted on 2023-01-09

3200 Resting state networks of awake adolescent and adult squirrel monkeys using ultra-high field (9.4T) functional magnetic resonance imaging

Yassin, W.; de Moura, F. B.; Withey, S. L.; Cao, L.; Kangas, B. D.; Bergman, J.; Kohut, S.

10.1101/2023.01.08.523000 — neuroscience — Posted on 2023-01-09

3201 Comparison of SARS-CoV-2 entry inhibitors based on ACE2 receptor or engineered Spike-binding peptides

Llewellyn, G. N.; Chen, H.-Y.; Rogers, G. L.; Huang, X.; Sell, P.; Henley, J. E.; Cannon, P. M.

10.1101/2023.01.05.522964 — microbiology — Posted on 2023-01-09

3202 Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

Labzin, L. I.; Chew, K. Y.; Eschke, K.; Wang, X.; Esposito, T.; Stocks, C. J.; Rae, J.; Patrick, R.; Mostafavi, H.; Hill, B.; Yordanov, T.; Holley, C. L.; Emming, S.; Fritzlar, S.; Mordant, F. L.; Steinfort, D. P.; Subbarao, K.; Nefzger, C. M.; Lagendijk, A. K.; Gordon, E.; Parton, R.; Short, K. R.; Londrigan, S. L.; Schroder, K.

10.1101/2022.03.22.485248 — immunology — Posted on 2023-01-09

3203 Unlocking de novo antibody design with generative artificial intelligence

Shanehsazzadeh, A.; Bachas, S.; Kasun, G.; Sutton, J. M.; Steiger, A. K.; Shuai, R.; Kohnert, C.; Morehead, A.; Brown, A.; Chung, C.; Luton, B. K.; Diaz, N.; McPartlon, M.; Knight, B.; Radach, M.; Bateman, K.; Spencer, D. A.; Cejovic, J.; Kopec-Belliveau, G.; Haile, R.; Yassine, E.; McCloskey, C.; Natividad, M.; Chapman, D.; Stojanovic, L.; Rakocevic, G.; Hannum, G.; Yapici, E.; Moran, K.; Caguiat, R.; Abdulhaqq, S.; Guo, Z.; Klug, L. R.; Gander, M.; Meier, J.

10.1101/2023.01.08.523187 — synthetic biology — Posted on 2023-01-09

3204 RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer

Cotto, K. C.; Feng, Y.-Y.; Ramu, A.; Richters, M.; Freshour, S.; Skidmore, Z. L.; Xia, H.; McMichael, J.; Kunisaki, J.; Campbell, K. M.; Po-Chen, T. H.; Rozycki, E. B.; Devarakonda, S.; Adkins, D.; Sankararaman, S.; Lin, Y.; Chapman, W.; Maher, C.; Arora, V.; Dunn, G.; Uppaulri, R.; Govindan, R.; Griffith, O. L.; Griffith, M.

10.1101/436634 — bioinformatics — Posted on 2023-01-09

3205 Nanoparticle-Conjugated TLR9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 Vaccines

Ou, B. S.; Picece, V. C. T. M.; Baillet, J.; Gale, E. C.; Powell, A. E.; Saouaf, O. M.; Yan, J.; Lopez Hernandez, H.; Appel, E.

10.1101/2023.01.02.522505 — bioengineering — Posted on 2023-01-09

3206 Broad and Durable Humoral Responses Following Single Hydrogel Immunization of SARS-CoV-2 Subunit Vaccine

Ou, B. S.; Saouaf, O. M.; Yan, J.; Bruun, T. U. J.; Baillet, J.; King, N. P.; Appel, E.

10.1101/2022.12.12.520166 — bioengineering — Posted on 2023-01-09

3207 Molecular Investigations of Selected Spike Protein Mutations in SARS-CoV-2: Delta and Omicron Variants and Omicron Subvariants

Roy, U.

10.1101/2022.05.25.493484 — biochemistry — Posted on 2023-01-09

3208 Performance of computational algorithms to deconvolve heterogeneous bulk tumor tissue depends on experimental factors

Hippen, A. A.; Omran, D. K.; Weber, L. M.; Jung, E.; Drapkin, R.; Doherty, J. A.; Hicks, S. C.; Greene, C. S.

10.1101/2022.12.04.519045 — bioinformatics — Posted on 2023-01-09

3209 CLOOME: contrastive learning unlocks bioimaging databases for queries with chemical structures

Sanchez-Fernandez, A.; Rumetshofer, E.; Hochreiter, S.; Klambauer, G.

10.1101/2022.11.17.516915 — bioinformatics — Posted on 2023-01-09

3210 Characterizing the landscape of gene expression variance in humans

Wolf, S.; Melo, D.; Garske, K. M.; Pallares, L. F.; Lea, A. J.; Ayroles, J. F.

10.1101/2022.11.15.516646 — genomics — Posted on 2023-01-09

3211 Phylogenomics reveals patterns of ancient hybridization and differential diversification contributing to phylogenetic conflict in Populus L. and Salix L.

Sanderson, B. J.; Ghambir, D.; Feng, G.; Hu, N.; Cronk, Q. C.; Percy, D. M.; Freaner, F. M.; Johnson, M. G.; Smart, L. B.; Keefover-Ring, K.; Yin, T.; Ma, T.; DiFazio, S. P.; Liu, J.; Olson, M. S.

10.1101/2023.01.04.522772 — evolutionary biology — Posted on 2023-01-09

3212 The causal role of the inferior temporal cortex in visual perception

Shahbazi, E.; Ma, T.; Pernus, M.; Scheirer, W. J.; Afraz, A.

10.1101/2022.10.24.513337 — neuroscience — Posted on 2023-01-09

3213 Mean amplitude of low frequency fluctuations measured by fMRI at 11.7T in the aging brain of mouse lemur primate

Garin, C. M.; Dhenain, M.

10.1101/2022.12.21.521367 — neuroscience — Posted on 2023-01-09

3214 Modulation of functional networks related to the serotonin neurotransmitter system by citalopram: evidence from a multimodal neuroimaging study

Boucherie, D.; Reneman, L.; Booij, J.; Martins, D.; Dipasquale, O.; Schrantee, A.

10.1101/2022.10.20.512503 — neuroscience — Posted on 2023-01-09

3215 Leveraging T-cell receptor - epitope recognition models to disentangle unique and cross-reactive T-cell response to SARS-CoV-2 during COVID-19 progression/resolution

Postovskaya, A.; Vujkovic, A.; de Block, T.; van Petersen, L.; van Frankenhuijsen, M.; Brosius, I.; Bottieau, E.; van Dijck, C.; Theunissen, C.; van Ierssel, S. H.; Vlieghe, E.; Bartholomeus, E.; Adriaensen, W.; Vanham, G.; Ogunjimi, B.; Laukens, K.; Vercauteren, K.; Meysman, P.

10.1101/2020.09.09.289355 — bioinformatics — Posted on 2023-01-09

3216 Heterogeneities in infection outcomes across species: sex and tissue differences in virus susceptibility

Roberts, K. E.; Longdon, B.

10.1101/2022.11.01.514663 — evolutionary biology — Posted on 2023-01-09

3217 Contributions of cell behavior to geometric order in embryonic cartilage

Mathias, S.; Adameyko, I.; Hellander, A.; Kursawe, J.

10.1101/2022.06.27.497736 — developmental biology — Posted on 2023-01-09

3218 Glial-dependent clustering of voltage-gated ion channels in Drosophila precedes myelin formation

Rey, S.; Ohm, H.; Moschref, F.; Zeuschner, D.; Klämbt, C.

10.1101/2023.01.09.523229 — neuroscience — Posted on 2023-01-09

3219 A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex

Valakh, V.; Wise, D. L.; Zhu, X. A.; Sha, M.; Fok, J.; Van Hooser, S.; Schectman, R.; Cepeda, I.; Kirk, R.; O'Toole, S. M.; Nelson, S. B.

10.1101/2021.10.20.465163 — neuroscience — Posted on 2023-01-09

3220 DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts

Shumliakivska, M.; Luxan, G.; Hemmerling, I.; Abplanalp, W. T.; Li, X.; Scheller, M.; Muller-Tidow, C.; Leuschner, F.; Schuhmacher, B.; Debes, A.; Glaser, S.-F.; Muhly Reinholz, M.; Kirschbaum, K.; Hoffmann, J.; Nagel, E.; Puntmann, V. O.; John, D.; Cremer, S.; Zeiher, A. M.; Dimmeler, S.

10.1101/2023.01.07.521766 — physiology — Posted on 2023-01-09

3221 The genomic diversity of Taiwanese Austronesian groups: implications for the "Into and Out of Taiwan" models

Liu, D.; Ko, A. M.-S.; Stoneking, M.

10.1101/2023.01.09.523210 — genomics — Posted on 2023-01-09

3222 Rapid Real-time Squiggle Classification for Read Until Using RawMap

Sadasivan, H.; Wadden, J.; Goliya, K.; Ranjan, P.; Dickson, R. P.; Blaauw, D.; Das, R.; Narayanasamy, S.

10.1101/2022.11.22.517599 — bioinformatics — Posted on 2023-01-09

3223 Age-dependent structural reorganization of utricular ribbon synapses

Wichmann, C.; Michanski, S.; Henneck, T.; Mukhopadhyay, M.; Steyer, A. M.; Gonzalez, P. A.; Grewe, K.; Ilgen, P.; Gültas, M.; Fornasiero, E. F.; Jakobs, S.; Möbius, W.; Vogl, C.; Pangrsic, T.; Rizzoli, S. O.

10.1101/2022.12.19.521049 — cell biology — Posted on 2023-01-09

3224 Break-induced replication is the primary recombination pathway in plant somatic hybrid mitochondria: a model for mt-HGT

Gandini, C. L.; Garcia, L. E.; Abbona, C. C.; Ceriotti, L. F.; Kushnir, S.; Geelen, D. L.; Sanchez-Puerta, M. V.

10.1101/2023.01.07.523103 — molecular biology — Posted on 2023-01-09

3225 Metataxonomic insights in the distribution of Lactobacillaceae in foods and food environments

Parente, E.; Zotta, T.; Giavalisco, M.; Ricciardi, A.

10.1101/2022.09.09.507241 — microbiology — Posted on 2023-01-09

3226 Astrocytic L-lactate signaling in the anterior cingulate cortex is essential for schema memory and neuronal mitochondrial biogenesis

Akter, M.; Hasan, M.; Ramkrishnan, A. S.; Zheng, X.; Iqbal, Z.; Fu, Z.; Lei, Z.; Karim, A.; Li, Y.

10.1101/2023.01.08.523156 — neuroscience — Posted on 2023-01-09

3227 In Breast Cancer ZMIZ1 Co-Regulates E2F2 as Part of the Estrogen Receptor-Mediated Cell-Cycle Response

Zhao, W.; Rose, S. F.; Blake, R.; Godicelj, A.; Cullen, A. E.; Stenning, J.; Gehrung, M.; Kumar, S.; Kishore, K.; Sawle, A.; Eldridge, M.; Giorgi, F. M.; Bridge, K. S.; Markowetz, F.; Holding, A. N.

10.1101/789610 — cancer biology — Posted on 2023-01-09

3228 Flotillin-Associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes

Haro-Moreno, J. M.; Lopez-Perez, M.; Alekseev, A.; Podoliak, E.; Kovalev, K.; Gordeliy, V.; Stepanauskas, R.; Rodriguez-Valera, F.

10.1101/2023.01.04.522823 — microbiology — Posted on 2023-01-09

3229 Restoring vascular endothelial autophagic flux reduces atherosclerotic lesions

Chatterjee, S.; Kheloufi, M.; Mazlan, S. M. I.; Loyer, X.; McKinsey, T. A.; Boulanger, C.; Coly, P.-M.

10.1101/2021.05.06.442901 — pathology — Posted on 2023-01-09

3230 Massively parallel single molecule tracking of sequence-dependent DNA mismatch repair in vivo

Kayikcioglu, T.; Zarb, J. S.; Mohapatra, S.; Lin, C.-T.; London, J. A.; Hansen, K. D.; Fishel, R.; Ha, T.

10.1101/2023.01.08.523062 — biophysics — Posted on 2023-01-09

3231 VICTORY for Cryo-EM: Ultra-High Atomic Resolution Cryo-EM Structure of β-Galactosidase at 1.1 A

Chakraborty, A.

10.1101/2023.01.08.522890 — molecular biology — Posted on 2023-01-09

3232 Larger but younger fish when growth outpaces mortality in heated ecosystem

Lindmark, M.; Karlsson, M.; Gardmark, A.

10.1101/2022.04.13.488128 — ecology — Posted on 2023-01-09

3233 Generative modeling of short, disordered proteins with homogeneous sequence composition

Taneja, I.; Lasker, K.

10.1101/2022.11.11.516154 — bioinformatics — Posted on 2023-01-09

3234 Detection of circular RNAs and their potential as biomarkers predictive of drug response

Nguyen, J.; Mammoliti, A.; Nair, S. K.; So, E.; Abbas-Aghababazadeh, F.; Eeles, C.; Smith, I.; Smirnov, P.; He, H. H.; Tsao, M.-S.; Haibe-Kains, B.

10.1101/2023.01.08.522775 — bioinformatics — Posted on 2023-01-09

3235 Genomic health is dependent on long-term population demographic history

Wootton, E.; Robert, C.; Taillon, J.; Shafer, A.; Cote, S.

10.1101/2022.08.16.503900 — genomics — Posted on 2023-01-08

3236 Information integration during bioelectric regulation of morphogenesis in the embryonic frog brain

Manicka, S.; Pai, V. P.; Levin, M.

10.1101/2023.01.08.523164 — developmental biology — Posted on 2023-01-08

3237 The multimodal action of G alpha q in coordinating growth and homeostasis in the Drosophila wing imaginal disc

Velagala, V.; Soundarrajan, D. K.; Unger, M. F.; Gazzo, D.; Kumar, N.; Li, J.; Zartman, J. J.

10.1101/2023.01.08.523049 — developmental biology — Posted on 2023-01-09

3238 A texture statistics encoding model reveals hierarchical feature selectivity across human visual cortex

Henderson, M. M.; Tarr, M. J.; Wehbe, L.

10.1101/2022.09.23.509292 — neuroscience — Posted on 2023-01-08

3239 Dynamical information enables inference of gene regulation at single-cell scale

Zhang, S. Y.; Stumpf, M. P. H.

10.1101/2023.01.08.523176 — systems biology — Posted on 2023-01-08

3240 Sequence to graph alignment using gap-sensitive co-linear chaining

Chandra, G.; Jain, C.

10.1101/2022.08.29.505691 — bioinformatics — Posted on 2023-01-08

3241 Shine: To explore specific, sensitive and conserved biomarkers from massive microbial genomic data within intrapopulations.

Ji, C.; Shao, J. J.

10.1101/2021.11.11.468318 — bioinformatics — Posted on 2023-01-08

3242 Engineering Escherichia coli to produce aromatic chemicals from ethylene glycol

Panda, S.; Zhou, J. F. J.; Feigis, M.; Harrison, E.; Ma, X.; Fung, V.; Mahadevan, R.; Zhou, K.

10.1101/2023.01.08.523183 — bioengineering — Posted on 2023-01-08

3243 Multifaceted effects of bycatch mitigation measures on target/non-target species for pelagic longline fisheries and consideration for bycatch management

Ochi, D.; Okamoto, K.; Ueno, S.

10.1101/2022.07.14.500149 — ecology — Posted on 2023-01-08

3244 Outsourcing Memory Through Niche Construction

Lee, E. D.; Flack, J.; Krakauer, D.

10.1101/2022.09.01.506204 — ecology — Posted on 2023-01-08

3245 Early life experience with natural odors modifies olfactory behavior through an associative process

Dylla, K. V.; O'Connell, T. F.; Hong, E. J.

10.1101/2023.01.08.523155 — neuroscience — Posted on 2023-01-08

3246 Cortical astrocyte N-Methyl-D-Aspartate receptors influence whisker barrel activity and sensory discrimination

Ahmadpour, N.; Kantroo, M.; Stobart, M. J.; Salamovska, T.; O'Hara, F.; Erickson, D.; Carrion-Falgarona, S.; Stobart, J. L.

10.1101/2023.01.08.523173 — neuroscience — Posted on 2023-01-08

3247 Moderating carbohydrate digestion rate promotes metabolic flexibility in mice

Hayes, A. M. R.; Swackhamer, C.; Quezada-Calvillo, R.; Butte, N. F.; Sterchi, E. E.; Nichols, B. L.; Hamaker, B. R.

10.1101/2023.01.08.523060 — physiology — Posted on 2023-01-08

3248 Epileptic seizure suppression: a computational approach for identification and control using real data

Ferres Brogin, J. A.; Faber, J.; Reyes-Garcia, S. Z.; Cavalheiro, E. A.; Domingues Bueno, D.

10.1101/2023.01.08.522971 — bioinformatics — Posted on 2023-01-08

3249 PASTE2: Partial Alignment of Multi-slice Spatially Resolved Transcriptomics Data

Liu, X.; Zeira, R.; Raphael, B.

10.1101/2023.01.08.523162 — bioinformatics — Posted on 2023-01-08

3250 Modeling of growth of Ulva sp. macroalgae in a controlled photobioreactor based on nitrogen accumulation dynamics

Zollmann, M.; Liberzon, A.; Golberg, A.

10.1101/2023.01.08.523140 — bioengineering — Posted on 2023-01-08

3251 Allele mining of eukaryotic translation initiation factor genes in Prunus species for the identification of new sources of resistance to sharka

Tricon, D.; Faivre-DARCIER, J.; Eyquard, J.-P.; Liu, S.; Decroocq, S.; Chague, A.; Liu, W.; Balakishiyeva, G.; Mamadov, A.; Turdiev, T.; Kostritsyna, T.; Asma, B.; Akparov, Z.; DECROOCQ, V.

10.1101/2023.01.08.523144 — genetics — Posted on 2023-01-08

3252 Target complementarity in cnidarians supports a common origin for animal and plant microRNAs

Admoni, Y.; Fridrich, A.; Moran, Y.

10.1101/2023.01.08.523153 — evolutionary biology — Posted on 2023-01-08

3253 UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity in Liver Disease.

Collins, A.; Scott, R.; Wilson, C. L.; Abbate, G.; Ecclestone, G. B.; Biddles, D.; Oakley, F.; Mann, J.; Mann, D. A.; Kenneth, N. S.

10.1101/2023.01.08.523142 — cell biology — Posted on 2023-01-08

3254 Transient septin sumoylation steers a Fir1-Skt5 protein complex between the split septin ring

Mueller, J.; Furlan, M.; Settele, D.; Grupp, B.; Johnsson, N.

10.1101/2023.01.08.523158 — cell biology — Posted on 2023-01-08

3255 An oviduct glycan increases sperm lifespan by diminishing ubiquinone and production of reactive oxygen species

Hughes, J.; McMorrow, K.; Bovin, N.; Miller, D.

10.1101/2023.01.08.523174 — cell biology — Posted on 2023-01-08

3256 DiPRO1 dependent transcriptional and epigenetic regulation distinctly controls the fate of muscle and mesenchymal cancer cells.

RICH, J.; BENNAROCH, M.; NOTEL, L.; PATALAKH, P.; ALBEROLA, J.; OPOLON, P.; BAWA, O.; RONDOF, W.; MARCHAIS, A.; DESSEN, P.; MEURICE, G.; POLROT, M.; SER-LE ROUX, K.; DROIN, N.; RASLOVA, H.; GEOERGER, B.; PIROZHKOVA, I. V.

10.1101/2023.01.08.523169 — molecular biology — Posted on 2023-01-08

3257 The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle

Aristodemou, A. E. N.; Rueda, D. S.; Taylor, G. P.; Bangham, C. R. M.

10.1101/2023.01.08.523159 — microbiology — Posted on 2023-01-08

3258 Electron transport chain RNAi in glutamate neurons extends life span, increases sleep, and decreases locomotor activity in Drosophila melanogaster

Landis, J. E.; Sungu, K.; Sipe, H.; Copeland, J. M.

10.1101/2023.01.08.523160 — neuroscience — Posted on 2023-01-08

3259 Fully automated detection of dendritic spines in 3D live cell imaging data using deep convolutional neural networks

Vogel, F. W.; Alipek, S.; Eppler, J.-B.; Triesch, J.; Bissen, D.; Acker-Palmer, A.; Rumpel, S.; Kaschube, M.

10.1101/2023.01.08.522220 — neuroscience — Posted on 2023-01-08

3260 Defective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling

Elguero, J. E.; Liu, G.; Tiemeyer, K.; Gandevia, H.; Duro, L.; McCall, K.

10.1101/2023.01.08.523170 — neuroscience — Posted on 2023-01-08

3261 Temporal Dynamics of Activity in Default Mode Network Suggests a Role in Top-down processing

Mastrovito, D.; Hanson, S.; Hanson, C.

10.1101/2023.01.08.523152 — neuroscience — Posted on 2023-01-08

3262 Analysis and design of single-cell experiments to harvest fluctuation information while rejecting measurement noise

Vo, H. D.; Forero, L. S.; Aguilera, L.; Munsky, B. E.

10.1101/2021.05.11.443611 — systems biology — Posted on 2023-01-08

3263 Leveraging Developmental Landscapes for Model Selection in Boolean Gene Regulatory Networks

Subbaroyan, A.; Sil, P.; Martin, O. C.; Samal, A.

10.1101/2023.01.08.523151 — systems biology — Posted on 2023-01-08

3264 The Arabidopsis LHT1 amino acid transporter contributes to Pseudomonas simiae-mediated plant-growth promotion by modulating bacterial metabolism in the rhizosphere

Agorsor, I. D. K.; Kagel, B. T.; Danna, C. H.

10.1101/2022.12.16.520833 — plant biology — Posted on 2023-01-08

3265 Ex-situ mycoremediation of petroleum polluted soils in Ogoniland, Nigeria

Anoliefo, G. O.; Nwaokolo, M.; Edegbai, B. O.; Ikhajiagbe, B.

10.1101/2023.01.08.523087 — plant biology — Posted on 2023-01-08

3266 Comparative Transcriptome Profiling Provides Insights into the Growth Promotion Activity of Pseudomonas fluorescens strain SLU99 in Tomato and Potato Plants

Hanifah, N. A. S.; Ghadamgahi, F.; Ghosh, S.; Ortiz, R.; Whisson, S. C.; Vetukuri, R. R.; Kalyandurg, P. B.

10.1101/2023.01.08.523145 — plant biology — Posted on 2023-01-08

3267 ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain

Chu, J.; Qiu, Z.; Yang, J.; Zhou, Y.; Chen, J.; Chen, K.; Zhang, C.; Cheng, H.; Koylass, N.; Liu, J. O.; Guan, Y.

10.1101/2023.01.08.523161 — physiology — Posted on 2023-01-08

3268 Data Fusion by Matrix Completion for Exposome Target Interaction Prediction

Wang, K.; Kim, N.; Bagherian, M.; Li, K.; Chou, E.; Colacino, J. A.; Dolinoy, D. C.; Sartor, M. A.

10.1101/2022.08.24.505125 — pharmacology and toxicology — Posted on 2023-01-08

3269 The cancer-specific lncRNA LISR customizes ribosomes to suppress anti-tumour immunity

Cinque, S.; Verheyden, Y.; Katopodi, V.; Knezevic, Z.; Demesmaeker, E.; Adnane, S.; Hanache, S.; Vendramin, R.; Stinkens, F.; Vervloesem, F.; Cuomo, A.; Pozniak, J.; Calabuig, A. C.; Tabruyn, S.; Bechter, O.; Baietti, M. F.; Groaz, E.; Bonaldi, T.; Leucci, E.

10.1101/2023.01.06.523012 — cancer biology — Posted on 2023-01-08

3270 Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls

Donovan, M. K. R.; Huang, Y.; Blume, J. E.; Wang, J.; Hornberg, D.; Mohtashemi, I.; Kim, S.; Ko, M.; Benz, R. W.; Platt, T. L.; Batzoglou, S.; Farokhzad, O. C.; Siddiqui, A.

10.1101/2022.01.07.475393 — cancer biology — Posted on 2023-01-08

3271 Massively parallel single molecule tracking of sequence-dependent DNA mismatch repair in vivo

Kayikcioglu, T.; Zarb, J. S.; Lin, C.-T.; Mohapatra, S.; London, J. A.; Hansen, K. D.; Rishel, R.; Ha, T.

10.1101/2023.01.08.523062 — biophysics — Posted on 2023-01-08

3272 Unmixing Fluorescence Image Data with Sparse and Low-Rank Poisson Regression

Wang, R.; Lemus, A. A.; Henneberry, C. M.; Ying, Y.; Feng, Y.; Valm, A. M.

10.1101/2023.01.06.523044 — bioinformatics — Posted on 2023-01-08

3273 The life span of steps in the enzyme-catalyzed reaction, its implications, and matters of general interest

Udema, I. I.

10.1101/2023.01.08.523157 — biochemistry — Posted on 2023-01-08

3274 Regulation of Nuclear Transcription by Mitochondrial RNA

Sriram, K.; Qi, Z.; Yuan, D.; Malhi, N. K.; Liu, X.; Calandrelli, R.; Luo, Y.; Jin, S.; Shi, J.; Salas, M.; Dang, R.; Armstrong, B.; Priceman, S. J.; Wang, P.; Liao, J.; Natarajan, R.; Zhong, S.; Chen, Z. B.

10.1101/2022.12.10.519922 — genomics — Posted on 2023-01-08

3275 Identification and characterisation of Botrylloides species from Aotearoa New Zealand coasts

Temiz, B.; Clarke, R. M.; Page, M.; Lamare, M.; Wilson, M. J.

10.1101/2021.09.08.459371 — genetics — Posted on 2023-01-08

3276 Aneuploidy in human embryos is associated with a maternal age- independent increase in mitochondrial DNA content and an enrichment of ultra-rare mitochondrial DNA variants

Ri, M. T.; Ree, N.; Oreshkov, S.; Tofilo, M.; Kirillova, A.; Zvereva, I.; Gunbin, K.; Yurov, V.; Salumets, A.; Woods, D. C.; Tilly, J. L.; Khrapko, K.; Fellay, J.; Mazunin, I.; Popadin, K.

10.1101/2022.10.14.512116 — genetics — Posted on 2023-01-08

3277 Acetylated dietary protein contributes to the acetylome in cells via KARS-mediated intra-translational deposition of acetyl-lysine in nascent protein

Guo, D.; Zhang, X.; He, J.; Yu, W.; Zhou, R.; Tong, F.; Yin, S.; Wang, Y.; Yang, Y.; Xu, X.; Wang, L.; Fan, M.; Feng, S.; Hong, C.; Huang, C.; Liu, K.; Ouyang, Z.; Wang, Y.

10.1101/2023.01.08.523135 — biochemistry — Posted on 2023-01-08

3278 The effect of in vitro starch digestibility on glycemic/insulinemic index of biscuits and bread made from non-conventional wholemeal/wholegrain flour mixtures.

Papadopoulos, C.; Anagnostopoulos, K.; Zisimopoulos, A.; Panopoulou, M.; Papazoglou, D.; Grapsa, A.; Tente, T.; Tentes, I.

10.1101/2023.01.08.523146 — biochemistry — Posted on 2023-01-08

3279 Artificial intelligence supports automated characterization of differentiated human pluripotent stem cells

Marzec-Schmidt, K.; Ghosheh, N.; Stahlschmidt, S. R.; Kuppers-Munther, B.; Synnergren, J.; Ulfenborg, B.

10.1101/2023.01.08.523148 — cell biology — Posted on 2023-01-08

3280 A versatile in situ cofactor enhancing system for meeting cellular demands for engineered metabolic pathways

Joroensuk, J.; Sutthaphirom, C.; Phonbuppha, J.; Chinantuya, W.; Kesornpun, C.; Akeratchatapan, N.; Kittipanukul, N.; Phatinuwat, K.; Atichartpongkul, S.; Fuangthong, M.; Pongtharangkul, T.; Hollmann, F.; Chaiyen, P.

10.1101/2023.01.08.523081 — synthetic biology — Posted on 2023-01-08

3281 Innate immunity can distinguish beneficial from pathogenic rhizosphere microbiota

Thoms, D.; Chen, M. Y.; Liu, Y.; Morales Moreira, Z.; Luo, Y.; Song, S.; Wang, N. R.; Haney, C. H.

10.1101/2023.01.07.523123 — plant biology — Posted on 2023-01-08

3282 Establishment and Characterization of Three Novel CAF Cell Lines from HNSCC Patients

Dwivedi, N.; Bahar, H.; D N, S.; Cherry, C. E.; Gangadharan, C.; Suresh, A.; Kuriakose, M. A.; Pillai, V.; P K, S.; Das, M.

10.1101/2023.01.08.523131 — cancer biology — Posted on 2023-01-08

3283 IraM Remodels the RssB Segmented Helical Linker to Stabilize σs against Degradation by ClpXP

Brugger, C.; Srirangam, S.; Deaconescu, A.

10.1101/2023.01.07.523045 — biophysics — Posted on 2023-01-08

3284 Fluorescence Image Data with Sparse and Low-Rank Poisson Regression

Wang, R.; Lemus, A. A.; Henneberry, C. M.; Ying, Y.; Feng, Y.; Valm, A. M.

10.1101/2023.01.06.523044 — bioinformatics — Posted on 2023-01-08

3285 Fertility decline in female mosquitoes is regulated by the orco olfactory co-receptor

David, O. G.; Sanchez, K. M.; Arce, A. V.; Costa-da-Silva, A. L.; Bellantuono, A. J.; DeGennaro, M.

10.1101/2023.01.07.523099 — genetics — Posted on 2023-01-08

3286 Adaptive evolution of carnivory in Nepenthes pitcher plants: a comparative transcriptomics and proteomics perspective

Scharmann, M.; Metali, F.; Grafe, U.; Widmer, A.

10.1101/2023.01.07.523112 — evolutionary biology — Posted on 2023-01-08

3287 Marine heatwaves threaten cryptic coral diversity and erode associations amongst coevolving partners

Starko, S.; Fifer, J. E.; Claar, D. C.; Davies, S. W.; Cunning, R.; Baker, A. C.; Baum, J. K.

10.1101/2023.01.07.522953 — ecology — Posted on 2023-01-08

3288 How coupled slow oscillations, spindles and ripples control neuronal processing and communication during human sleep

Staresina, B.; Niediek, J.; Borger, V.; Surges, R.; Mormann, F.

10.1101/2023.01.08.523138 — neuroscience — Posted on 2023-01-08

3289 A converged ubiquitin-proteasome pathway for the degradation of TOC and TOM tail-anchored receptors

Yang, M.; Chen, S.; Lim, S.-L.; Yang, L.; Zhong, J. Y.; Chan, K. C.; Zhao, Z.; Wong, K.-B.; Wang, J.; Lim, B. L.

10.1101/2023.01.07.523072 — plant biology — Posted on 2023-01-08

3290 Elevated CO2 alters photosynthesis, growth and susceptibility to powdery mildew of oak seedlings

Sanchez-Lucas, R.; Mayoral, C.; Raw, M.; Mousouraki, M.-A.; Luna, E.

10.1101/2023.01.07.523094 — plant biology — Posted on 2023-01-08

3291 Comparative plant growth responses in a crop-weed mix; a case study of Zea mays (L.) and Eleusine indica (L.) Gaertn

Ikhajiagbe, B.; Musa, S. I.; Ekhator, E. F.

10.1101/2023.01.07.523107 — plant biology — Posted on 2023-01-08

3292 Enkurin: A novel marker for myeloproliferative neoplasms from platelet, megakaryocyte, and whole blood specimens.

Sumanth, M. S.; Liu, Y.; Wu, J.; Fechter, L.; Murugesan, K.; Maecker, H.; Gotlib, J.; Zehnder, J.; Paulmurugan, R.; Krishnan, A.

10.1101/2023.01.07.523111 — cancer biology — Posted on 2023-01-08

3293 Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel

Pei, D.; Mingfeng, Z.; Shan, Y.

10.1101/2023.01.07.523124 — biophysics — Posted on 2023-01-08

3294 Mechanism of physical force induced human slack channel desensitization

Zhang, M.; Shan, Y.; Pei, D.

10.1101/2023.01.07.523125 — biophysics — Posted on 2023-01-08

3295 Identification and Characterization of novel long non-coding RNAs in vascular smooth cells

Solomon, C. U.; McVey, D. G.; Andreadi, C.; Gong, P.; Turner, L.; Khemiri, S.; Chamberlain, J. C.; Webb, T. R.; Samani, N.; Ye, S.

10.1101/2023.01.06.523019 — bioinformatics — Posted on 2023-01-08

3296 Protein language model embedded geometric graphs power inter-protein contact prediction

Si, Y.; Yan, C.

10.1101/2023.01.07.523121 — bioinformatics — Posted on 2023-01-08

3297 Unsupervised Contrastive Peak Caller for ATAC-seq

Vu, H. T. H.; Zhang, Y.; Tuteja, G.; Dorman, K.

10.1101/2023.01.07.523108 — bioinformatics — Posted on 2023-01-08

3298 Decoding CRISPR-Cas9 PAM recognition with UniDesign

Huang, X.; Zhou, J.; Yang, D.; Zhang, J.; Xia, X.; Chen, Y. E.; Xu, J.

10.1101/2023.01.08.523136 — bioinformatics — Posted on 2023-01-08

3299 Superhydrophobic Rotation-Chip for Computer-Vision Identification of Drug-Resistant Bacteria

He, J.; Peng, R.; Yuqing, H.; Karim, R.; Lu, G.; Du, K.

10.1101/2023.01.06.523046 — bioengineering — Posted on 2023-01-08

3300 Incorporating Radiopacity into Implantable Polymeric Biomedical Devices for Clinical Radiological Monitoring

Pawelec, K. M.; Tu, E.; Chakravarty, S.; Hix, J. M. L.; Buchanan, L.; Kenney, L.; Buchanan, F.; Chatterjee, N.; Das, S.; Alessio, A.; Shapiro, E.

10.1101/2023.01.06.523025 — bioengineering — Posted on 2023-01-08

3301 ColMA/PEGDA Bioink for Digital Light Processing 3D Printing in Biomedical Engineering

Chen, J.

10.1101/2023.01.08.523134 — bioengineering — Posted on 2023-01-08

3302 Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency

C. Marques, F.; Boaretti, D.; Walle, M.; C. Scheuren, A.; A. Schulte, F.; Muller, R.

10.1101/2023.01.07.523082 — bioengineering — Posted on 2023-01-08

3303 Genetic diversity of North American popcorn germplasm and the effect of population structure on nicosulfuron response

Sullivan, M.; Williams, M. M.; Studer, A. J.

10.1101/2023.01.06.523022 — genetics — Posted on 2023-01-08

3304 Genomic evidence for rapid speciation and gene flow between sympatric carnivorous Nepenthes pitcher plants

Scharmann, M.; Metali, F.; Grafe, U.; Widmer, A.

10.1101/2023.01.07.522986 — evolutionary biology — Posted on 2023-01-08

3305 Temperature and food chain length, but not latitude, explain region-specific kelp forest responses to an unprecedented heatwave

Starko, S.; Timmer, B.; Reshitnyk, L.; Csordas, M.; McHenry, J.; Schroeder, S.; Hessing-Lewis, M.; Costa, M.; Zielinski, A.; Zielinski, R.; Cook, S.; Underhill, R.; Boyer, L.; Fretwell, C.; Yakimishyn, J.; Heath, W. A.; Gruman, C.; Baum, J. K.; Neufeld, C. J.

10.1101/2023.01.07.523109 — ecology — Posted on 2023-01-08

3306 Impact of urbanization on the taxonomic and functional diversity of spider assemblages in Guwahati City, Assam, India

Sharma, A.; Deka, B.; Bishaya, P.; Kumar, R.; Sharma, N.

10.1101/2023.01.07.523076 — ecology — Posted on 2023-01-08

3307 Habitat amount, temperature and biotic interactions drive community structure, life-history traits, and performance traits of cavity-nesting bees and wasps and their natural enemies in cities

Casanelles Abella, J.; Pellissier, L.; Aleixo, C.; Alos Orti, M.; Chiron, F.; Deguines, N.; Laanisto, L.; Myczko, Łukasz; Niinemets, U.; Pinho, P.; Samson, R.; Tryjanowski, P.; Villarroy Villalba, L.; Moretti, M.

10.1101/2023.01.07.522464 — ecology — Posted on 2023-01-08

3308 C. elegans SMOC-1 interacts with both BMP and glypican to regulate BMP signaling

DeGroot, M. S.; Williams, B.; Chang, T. Y.; Maas Gamboa, M. L.; Larus, I. M.; Fromme, J. C.; Liu, J.

10.1101/2023.01.06.523017 — developmental biology — Posted on 2023-01-08

3309 Follicle stimulating hormone signaling opposes the DRL-1/FLR-4 MAP Kinases to balance p38-mediated growth and lipid homeostasis in C. elegans

Torzone, S. K.; Park, A. Y.; Breen, P. C.; Cohen, N. R.; Dowen, R. H.

10.1101/2023.01.07.523122 — developmental biology — Posted on 2023-01-08

3310 A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4

Gumusderelioglu, S.; Resch, L.; Brock, T.; Undiagnosed Diseases Network, ; Luxton, G. G.; Tan, Q. K.-G.; Hopkins, C. E.; Starr, D. A.

10.1101/2023.01.07.523106 — cell biology — Posted on 2023-01-08

3311 Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages

Kanie, T.; Ng, R.; Abbott, K. L.; Pongs, O.; Jackson, P. K.

10.1101/2023.01.06.523037 — cell biology — Posted on 2023-01-08

3312 A hierarchical pathway for assembly of the distal appendages that organize primary cilia

Kanie, T.; Love, J. F.; Fisher, S. D.; Gustavsson, A.-K.; Jackson, P. K.

10.1101/2023.01.06.522944 — cell biology — Posted on 2023-01-08

3313 INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation

10.1101/2023.01.07.522948 — molecular biology — Posted on 2023-01-08

3314 Viral and bacterial ecogenomics in globally expanding red snow blooms

Barno, A. R.; Green, K. T.; Rohwer, F.; Silveira, C. R.

10.1101/2023.01.07.523113 — molecular biology — Posted on 2023-01-08

3315 Immune response modulation by Pseudomonas aeruginosa persister cells

Marques, C. N. H.; Hastings, C. J.; Himmler, G. E.; Patel, A.

10.1101/2023.01.07.523056 — microbiology — Posted on 2023-01-08

3316 The NO Answer for Autism Spectrum Disorder

Tripathi, M. K.; Ojha, S. K.; Kartawy, M.; Hamoudi, W.; Aran, A.; Amal, H.

10.1101/2023.01.07.523095 — neuroscience — Posted on 2023-01-08

3317 The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation

Zhu, J.; Xian, Q.; Hou, X.; Wong, K. F.; Zhu, T.; Chen, Z.; He, D.; Kala, S.; Jing, J.; Wu, Y.; Zhao, X.; Li, D.; Guo, J.; Qiu, Z.; Sun, L.

10.1101/2023.01.07.523089 — neuroscience — Posted on 2023-01-08

3318 Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in Arabidopsis

Lopes, F. L.; Formosa-Jordan, P.; Malivert, A.; Margalha, L.; Confraria, A.; Feil, R.; Lunn, J. E.; Jönsson, H.; Landrein, B.; Baena-Gonzalez, E.

10.1101/2023.01.08.522175 — plant biology — Posted on 2023-01-08

3319 Cytokinins regulate spatially-specific ethylene production to control root growth in Arabidopsis

Yamoune, A.; Zdarska, M.; Depaepe, T.; Korytarova, A.; Skalak, J.; Berendzen, K. W.; Mira-Rodado, V.; Tarr, P.; Spackova, E.; Badurova, L.; Parizkova, B.; Franczyk, A.; Kovacova, I.; Pernisova, M.; Novak, O.; Meyerowitz, E. M.; Harter, K.; Van Der Straeten, D.; Hejatko, J.

10.1101/2023.01.07.522790 — plant biology — Posted on 2023-01-08

3320 Pre-anthesis spike growth dynamics and its association to yield components among elite bread wheat cultivars (Triticum aestivum L. spp.) under Mediterranean climate

Roychowdhury, R.; Zilberman, O.; Chandrasekhar, K.; Curzon, A. Y.; Nashef, K.; Abbo, S.; Slafer, G. A.; Bonfil, D. J.; Ben-David, R.

10.1101/2023.01.08.523132 — plant biology — Posted on 2023-01-08

3321 TCDD dysregulation of lncRNA expression, liver zonation and intercellular communication across the liver lobule

Karri, K.; Waxman, D. J.

10.1101/2023.01.07.523119 — pharmacology and toxicology — Posted on 2023-01-08

3322 In Vivo Biocompatibility of ZIF-8 for Antigen Slow Release via Intranasal Administration

Kumari, S.; Howlett, T. S.; Ehrman, R. N.; Koirala, S.; Trashi, O.; Trashi, I.; Wijesundara, Y. H.; Gassensmith, J. J.

10.1101/2023.01.07.523104 — pharmacology and toxicology — Posted on 2023-01-08

3323 EnsDTI-kinase: Web-server for Predicting Kinase-Inhibitor Interactions with Ensemble Computational Methods and Its Applications

Lu, Y.; Lim, S.; Park, S.; Choi, M.; Cho, C.; Kang, S.; Kim, S.

10.1101/2023.01.06.523052 — bioinformatics — Posted on 2023-01-08

3324 DPHL v2: An updated and comprehensive DIA pan-human assay library for quantifying more than 14,000 proteins.

Xue, Z.; Zhu, T.; Zhang, F.; Zhang, C.; Xiang, N.; Qian, L.; Yi, X.; Sun, Y.; Liu, W.; Cai, X.; Wang, L.; Dai, X.; Yue, L.; Li, L.; Pham, T. V.; Piersma, S. R.; Xiao, Q.; Luo, M.; Lu, C.; Zhu, J.; Zhao, Y.; Wang, G.; Xiao, J.; Liu, T.; Liu, Z.; He, Y.; Wu, Q.; Gong, T.; Zhu, J.; Zheng, Z.; Ye, J.; Li, Y.; Jimenez, C. R.; A, J.; Guo, T.

10.1101/2023.01.07.523067 — bioinformatics — Posted on 2023-01-08

3325 Ex Vivo Biomechanical Characterization of Umbilical Vessels: Possible Shunts in Congenital Heart Palliation

Murtada, S.-I.; Ramachandra, A. B.; Humphrey, J. D.

10.1101/2023.01.07.523118 — bioengineering — Posted on 2023-01-08

3326 Linking fluid-axons interactions to the macroscopic fluid transport properties of the brain

Yuan, T.; Zhan, W.; Dini, D.

10.1101/2023.01.06.523035 — bioengineering — Posted on 2023-01-08

3327 Secretion encoded single-cell sequencing (SEC-seq) uncovers gene expression signatures associated with high VEGF-A secretion in mesenchymal stromal cells

Udani, S.; Langerman, J.; Koo, D.; Baghdasarian, S.; Cheng, B.; Kang, S.; Soemardy, C.; de Rutte, J.; Plath, K.; Di Carlo, D.

10.1101/2023.01.07.523110 — bioengineering — Posted on 2023-01-08

3328 Replicative aging impedes stress-induced assembly of a key human protein disaggregase

Mathangasinghe, Y.; Alberts, N.; Rosado, C. J.; Cox, D.; Payne, N. L.; Ormsby, A. R.; Alp, K. M.; Sakson, R.; Uthishtran, S.; Ruppert, T.; Arumugam, S.; Hatters, D. M.; Kampinga, H. H.; Nillegoda, N. B.

10.1101/2022.06.25.497591 — cell biology — Posted on 2023-01-08

3329 Long-Read Genome Assembly and Gene Model Annotations for the Rodent Malaria Parasite Plasmodium yoelii 17XNL

Godin, M. J.; Sebastian, A.; Albert, I.; Lindner, S. E.

10.1101/2023.01.06.523040 — microbiology — Posted on 2023-01-08

3330 A study on packed cell volume for deducing hemoglobin: Cholistani camels in perspective

Farooq, U.; Idris, M.; Sajjad, N.; Lashari, M. H.; Ahmad, S.; Rehman, Z. U.; Rashid, H.; Mahmood, A.; Hameed, S.

10.1101/2022.11.15.516630 — physiology — Posted on 2023-01-08

3331 DNA methylation signature in NSD2 loss-of-function variants appeared similar to that in Wolf-Hirschhorn syndrome

Kawai, T.; Kinoshita, S.; Takayama, Y.; Onishi, E.; Kamura, H.; Kojima, K.; Kikuchi, H.; Terao, M.; Sugawara, T.; Migita, O.; Kagami, M.; Isojima, T.; Yamaguchi, Y.; Wakui, K.; Ohashi, H.; Shimizu, K.; Mizuno, S.; Okamoto, N.; Fukushima, Y.; Takada, F.; Kosaki, K.; Takada, S.; Akutsu, H.; Ura, K.; Nakabayashi, K.; Hata, K.

10.1101/2023.01.06.522834 — genetics — Posted on 2023-01-08

3332 Ehrlichia Notch signaling induction promotes XIAP stability and inhibits apoptosis

McBride, J. W.; Patterson, L. L.; Byerly, C. D.; Solomon, R.; Pittner, N.; Bui, D. C.; Patel, J.

10.1101/2023.01.06.523066 — microbiology — Posted on 2023-01-08

3333 Theory and practice of using cell strainers to sort Caenorhabditis elegans by size

Lanier, V. J.; White, A. M.; Faumont, S.; Lockery, S.

10.1101/2023.01.07.523116 — bioengineering — Posted on 2023-01-08

3334 Hand preference predicts behavioral responses to threats in Barbary macaques

van Dijk, E. S. J.; Bhattacharjee, D.; Belli, E.; Massen, J. J. M.

10.1101/2023.01.06.523039 — animal behavior and cognition — Posted on 2023-01-08

3335 A multicolor suite for deciphering population coding in calcium and cAMP in vivo

Yokoyama, T.; Manita, S.; Uwamori, H.; Tajiri, M.; Imayoshi, I.; Yagishita, S.; Murayama, M.; Kitamura, K.; Sakamoto, M.

10.1101/2023.01.06.522686 — neuroscience — Posted on 2023-01-08

3336 Metabolite T1 relaxation times differ across the adult lifespan

Murali-Manohar, S.; Gudmundson, A. T.; Hupfeld, K. E.; Zöllner, H. J.; Hui, S. C. N.; Song, Y.; Davies-Jenkins, C. W.; Gong, T.; Wang, G.; Oeltzschner, G.; Edden, R. A. E.

10.1101/2023.01.06.522927 — neuroscience — Posted on 2023-01-08

3337 Developing hippocampal spheroids model ictogenesis and epileptogenesis

Ephraim, J. W.; Caron, D.; Canal-Alonso, A.; Corchado, J. M.; Palazzolo, G.; Panuccio, G.

10.1101/2023.01.06.523024 — neuroscience — Posted on 2023-01-08

3338 Gene Expression Changes in Cultured Reactive Rat Astrocyte Models and Comparison to Device-Associated Effects in the Brain

Riggins, T. E.; Whitsitt, Q. A.; Saxena, A.; Hunter, E.; Hunt, B.; Thompson, C. H.; Moore, M. G.; Purcell, E. K.

10.1101/2023.01.06.522870 — neuroscience — Posted on 2023-01-08

3339 If it's real, could it be an eel?

Foxon, F.

10.1101/2023.01.07.523085 — zoology — Posted on 2023-01-08

3340 The complex inhibitory mechanism of glycomimetics with human heparanase

Whitefield, C.; Vo, Y.; Schwartz, B. D.; Hepburn, C.; Ahmed, F. H.; Onagi, H.; Banwell, M. G.; Nelms, K.; Malins, L. R.; Jackson, C. J.

10.1101/2023.01.05.522817 — biochemistry — Posted on 2023-01-08

3341 Contrast Sensitivity Function in Deep Networks

Akbarinia, A.; Morgenstern, Y.; Gegenfurtner, K. R.

10.1101/2023.01.06.523034 — animal behavior and cognition — Posted on 2023-01-08

3342 Rapid automated 3-D pose estimation of larval zebrafish using a physical model-trained neural network

Ravan, A. S.; Feng, R.; Gruebele, M.; Chemla, Y. R.

10.1101/2023.01.06.522821 — animal behavior and cognition — Posted on 2023-01-08

3343 Scalable Apparatus to Measure Posture and Locomotion (SAMPL): a high-throughput solution to study unconstrained vertical behavior in small animals

Zhu, Y.; Auer, F.; Gelnaw, H.; Davis, S. N.; Hamling, K. R.; May, C. E.; Ahamed, H.; Ringstad, N.; Nagel, K. I.; Schoppik, D.

10.1101/2023.01.07.523102 — neuroscience — Posted on 2023-01-07

3344 A detailed input-output characterization of single neurons reveals the synaptic basis of spontaneous spiking in recurrent networks

Bartram, J.; Franke, F.; Kumar, S. S.; Buccino, A. P.; Xue, X.; Ganswein, T.; Schroter, M.; Kim, T.; Kasuba, K. C.; Hierlemann, A.

10.1101/2023.01.06.523018 — neuroscience — Posted on 2023-01-08

3345 Activity Hierarchy Measurement to Establish Trace Memory-eligible "Primed" Neurons

Zhou, Y.; Qiu, L.; Lyon, M.; Chen, X.

10.1101/2023.01.06.523038 — neuroscience — Posted on 2023-01-08

3346 A biochemical analysis of Black Soldier fly (Hermetia illucens) larval frass plant growth promoting activity

Green, T. R.

10.1101/2023.01.06.523026 — biochemistry — Posted on 2023-01-08

3347 Multifaceted effects of bycatch mitigation measures on target/non-target species for pelagic longline fisheries and consideration for bycatch management

Ochi, D.; Okamoto, K.; Ueno, S.

10.1101/2022.07.14.500149 — ecology — Posted on 2023-01-08

3348 Different methods to estimate the phase of neural rhythms agree, but only during times of low uncertainty

Wodeyar, A.; Marshall, F. A.; Chu, C. J.; Eden, U. T.; Kramer, M. A.

10.1101/2023.01.05.522914 — neuroscience — Posted on 2023-01-07

3349 Efficient minimizer orders for large values of k using minimum decycling sets

Pellow, D.; Pu, L.; Ekim, B.; Kotlar, L.; Berger, B.; Shamir, R.; Orenstein, Y.

10.1101/2022.10.18.512682 — bioinformatics — Posted on 2023-01-07

3350 LHX2 in germ cells control tubular organization in the developing mouse testis

Singh, N.; Singh, D.; Bhide, A.; Sharma, R.; Bhowmick, S.; Patel, V.; Modi, D.

10.1101/2022.12.29.522214 — developmental biology — Posted on 2023-01-07

3351 Endothelial SMAD1/5 signaling couples angiogenesis to osteogenesis during long bone growth

Lang, A.; Benn, A.; Wolter, A.; Balcaen, T.; Collins, J.; Kerckhofs, G.; Zwijsen, A.; Boerckel, J. D.

10.1101/2023.01.07.522994 — developmental biology — Posted on 2023-01-07

3352 RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1alpha

Dumesic, P. A.; Wilensky, S. E.; Bose, S.; Van Vranken, J. G.; Gygi, S. P.; Spiegelman, B. M.

10.1101/2023.01.06.522985 — cell biology — Posted on 2023-01-07

3353 Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis

Alexanian, M.; Padmanabhan, A.; Nishino, T.; Travers, J. G.; Ye, L.; Lee, C. Y.; Sadagopan, N.; Huang, Y.; Pelonero, A.; Auclair, K.; Zhu, A.; Gonzalez Teran, B.; Flanigan, W.; Kim, C. K.-S.; Lumbao-Conradson, K.; Costa, M.; Jain, R.; Charo, I.; Haldar, S. M.; Pollard, K. S.; Vagnozzi, R. J.; McKinsey, T. A.; Przytycki, P. F.; Srivastava, D.

10.1101/2023.01.06.522937 — molecular biology — Posted on 2023-01-07

3354 An axon - T cell feedback loop enhances inflammation and axon degeneration

Liu, T.; Wang, H.; Kutsovsky, D. Y.; Ohn, C. Y.; Patel, N.; Yang, J.; Simon, D. J.

10.1101/2023.01.06.523014 — neuroscience — Posted on 2023-01-07

3355 The interaction between random and systematic visual stimulation and infraslow quasiperiodic spatiotemporal patterns of whole brain activity

Xu, N.; Smith, D. M.; Jeno, G.; Seeburger, D. T.; Schumacher, E. H.; Keilholz, S. D.

10.1101/2022.12.06.519337 — neuroscience — Posted on 2023-01-07

3356 Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles

Mason, A. J.; Keeler, A. B.; Kabir, F.; Winckler, B.; Deppmann, C. D.

10.1101/2022.05.24.493096 — neuroscience — Posted on 2023-01-07

3357 Selective inhibition of excitatory synaptic transmission alters the emergent bursting dynamics of in vitro neural networks

Weir, J. S.; Christiansen, N.; Sandvig, A.; Sandvig, I.

10.1101/2022.09.08.507095 — neuroscience — Posted on 2023-01-07

3358 Hetnet connectivity search provides rapid insights into how two biomedical entities are related

Himmelstein, D. S.; Zietz, M.; Rubinetti, V.; Kloster, K.; Heil, B. J.; Alquaddoomi, F.; Hu, D.; Nicholson, D. N.; Hao, Y.; Sullivan, B. D.; Nagle, M. W.; Greene, C. S.

10.1101/2023.01.05.522941 — bioinformatics — Posted on 2023-01-07

3359 HiDDEN: A machine learning label refinement method for detection of disease-relevant populations in case-control single-cell transcriptomics

Goeva, A.; Dolan, M.-J.; Luu, J.; Garcia, E.; Boiarsky, R.; Gupta, R. M.; Macosko, E.

10.1101/2023.01.06.523013 — bioinformatics — Posted on 2023-01-07

3360 Genomes of the human filarial parasites Mansonella perstans and Mansonella ozzardi

Sinha, A.; Li, Z.; Poole, C. B.; Morgan, R. D.; Ettwiller, L.; Lima, N. F.; Ferreira, M. U.; Fombad, F. F.; Wanji, S.; Carlow, C. K. S.

10.1101/2023.01.06.523030 — genomics — Posted on 2023-01-07

3361 Development of Multiomics in situ Pairwise Sequencing (MiP-Seq) for Single-cell Resolution Multidimensional Spatial Omics

Wu, X.; Xu, W.; Deng, L.; Li, Y.; Wang, Z.; Sun, L.; Gao, A.; Wang, H.; Yang, X.; Wu, C.; Zou, Y.; Yan, K.; Liu, Z.; Zhang, L.; Du, G.; Yang, L.; Lin, D.; Wang, P.; Han, Y.; Fu, Z. F.; Dai, J.; Cao, G.

10.1101/2023.01.07.523058 — molecular biology — Posted on 2023-01-07

3362 A CheZ orthologue in Campylobacter jejuni plays a role in chemotaxis through conserved phosphatase activity

Jama, A. S.; Ketley, J. M.

10.1101/2023.01.06.523011 — microbiology — Posted on 2023-01-07

3363 M. tuberculosis antigen-responsive IL17+ CD4 T cells are disproportionately spared in ART-suppressed HIV

Ogongo, P.; Tran, A.; Marzan, F.; Gingrich, D.; Krone, M.; Aweeka, F.; Lindestam Arlehamn, C. S.; Martin, J. N.; Deeks, S.; Hunt, P. W.; Ernst, J. D.

10.1101/2023.01.06.523027 — immunology — Posted on 2023-01-07

3364 Diverging Parkinson's Disease Pathology between GBAN370S ,LRRK2G2019S and engineered SNCAA53T iPSC-derived Dopaminergic Neurons

Fathi, A.; Bakshy, K.; Zieghami, L.; Fiene, R.; Bradley, R.; Dickerson, S.; Carlson, C.; Schachtele, S.; Liu, J.

10.1101/2023.01.06.521264 — neuroscience — Posted on 2023-01-07

3365 APOE4, Age & Sex Regulate Respiratory Plasticity Elicited By Acute Intermittent Hypercapnic-Hypoxia

Nair, J.; Welch, J. F.; Marciante, A. B.; Hou, T.; Lu, Q.; Fox, E. J.; Mitchell, G. S.

10.1101/2023.01.06.522840 — neuroscience — Posted on 2023-01-07

3366 Growth responses of Celosia argentea L. in soils polluted with microplastics

Ikhajiagbe, B.; Omoregie, G. O.; Adama, S. O.; Esheya, K. U.

10.1101/2023.01.07.523084 — plant biology — Posted on 2023-01-07

3367 Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in TP53, KMT genes and PDGFB fusions

Das, S.; Idate, R.; Lana, S. E.; Regan, D. P.; Duval, D. L.

10.1101/2023.01.06.522911 — cancer biology — Posted on 2023-01-07

3368 Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Lee, E.; Cullen, C.; Murad, J. P.; Gumber, D.; Park, A.; Yang, J.; Stern, L.; Adkins, L.; Dhapola, G.; Gittins, B.; Chang, W.-C.; Martinez, C.; Woo, Y.; Cristea, M.; Rodriguez, L.; Ishihara, J.; Lee, J. K.; Forman, S. J.; Wang, L.; Priceman, S. J.

10.1101/2023.01.06.522784 — cancer biology — Posted on 2023-01-07

3369 Passive endocytosis in protocells enables nutrient transport bypassing permeability limits

Zhang, S. J.; Anees, P.; Krishnan, Y.; Fai, T. G.; Szostak, J. W.; Wang, A.

10.1101/2023.01.07.522792 — biophysics — Posted on 2023-01-07

3370 Convergent behavior of extended stalk regions from staphylococcal surface proteins with widely divergent sequence patterns

Yarawsky, A. E.; Ori, A. L.; English, L. R.; Whitten, S. T.; Herr, A. B.

10.1101/2023.01.06.523059 — biophysics — Posted on 2023-01-07

3371 High Throughput Proteomic Analysis of Heterogeneous Cell Populations with NanoDTSC

Kreimer, S.; Binek, A.; Chazarin, B.; Cho, J. H.; Haghani, A.; Hutton, A.; Marban, E.; Mastali, M.; Meyer, J. G.; Ribeiro Mesquita, T. R.; Song, Y.; Van Eyk, J.; Parker, S. J.

10.1101/2023.01.06.522908 — biochemistry — Posted on 2023-01-07

3372 A biochemical analysis of Black Soldier fly (Hermetia illucens) larval frass plant growth promoting activity

Green, T. R.

10.1101/2023.01.06.523026 — biochemistry — Posted on 2023-01-07

3373 Surface frustration re-patterning underlies the structural landscape and evolvability of fungal orphan candidate effectors

Derbyshire, M. C.; Raffaele, S.

10.1101/2023.01.06.522876 — genomics — Posted on 2023-01-07

3374 Adaptation of prokaryotic toxins for negative selection and cloning-independent markerless mutagenesis (CIMM) in Streptococcus species

Li, L.; Qin, H.; Zou, Z.; Kreth, J.; Merritt, J.

10.1101/2023.01.03.522674 — genetics — Posted on 2023-01-07

3375 Leaf decomposing fungi influence Saccharomyces paradoxus growth across carbon environments

El-Khatib, S.; Lambert, M. G.; Reed, M. N.; Goncalves, M. B.; Boynton, P. J.

10.1101/2023.01.06.523016 — ecology — Posted on 2023-01-07

3376 Development of Encarsia tabacivora (Viggiani) (Hymenoptera: Aphelinidae) in nymphs of Bemisia tabaci (Gennadius) MEAN 1 (Hemiptera: Aleyrodidae)

Gamarra, H. A.; Sporleder, M.; Supanta, L.; Rodriguez, A. R.; Kroschel, J.; Kreuze, J. F.

10.1101/2023.01.06.486630 — developmental biology — Posted on 2023-01-07

3377 Gaudichaudione H inhibits Herpes Simplex Virus-1 replication by regulating cellular nuclear factor-κB in an interferon-γ-independent manner

Feng, J.; Tang, Y.; Fu, W.; Xu, H.

10.1101/2023.01.06.523065 — cell biology — Posted on 2023-01-07

3378 Identification of common sequence motifs shared exclusively among selectively packed exosomal pathogenic microRNAs during rickettsial infections

Bei, J.; Qiu, Y.; Cockrell, D.; Chang, Q.; Husseinzadeh, S.; Zhou, C.; Gaitas, A.; Fang, X.; Jin, Y.; Khanipov, K.; Saito, T. B.; Gong, B.

10.1101/2023.01.06.522907 — molecular biology — Posted on 2023-01-07

3379 All-optical spatiotemporal mapping of ROS dynamics across mitochondrial microdomains in situ

Koren, S. A.; Selim, N. A.; De La Rosa, L.; Horn, J.; Farooqi, M. A.; Wei, A. Y.; Mueller-Eigner, A.; Emerson, J.; Johnson, G. V.; Wojtovich, A. P.

10.1101/2023.01.07.523093 — molecular biology — Posted on 2023-01-07

3380 Anaerobe isolation from denitrifying benzene-degrading enrichment culture and their capacity to mineralize benzene

Eziuzor, S. C.; Vogt, C.

10.1101/2023.01.07.522375 — microbiology — Posted on 2023-01-07

3381 Long timescale anti-directional rotation in Drosophila optomotor behavior

Mano, O.; Choi, M.; Tanaka, R.; Creamer, M. S.; Castelo Branco Matos, N.; Shomar, J.; Badwan, B. A.; Clandinin, T. R.; Clark, D. A.

10.1101/2023.01.06.523055 — neuroscience — Posted on 2023-01-07

3382 Using soybean historical field trial data to study genotype by environment variation and identify mega-environments with the integration of genetic and non-genetic factors

Dalsente Krause, M.; Olimpio das Gracas Dias, K.; Singh, A. K.; Beavis, W. D.

10.1101/2022.04.11.487885 — genetics — Posted on 2023-01-07

3383 Opponent Learning with Different Representations in the Cortico-Basal Ganglia Pathways Can Develop Obsession-Compulsion Cycle

Sato, R.; Shimomura, K.; Morita, K.

10.1101/2022.10.25.513649 — neuroscience — Posted on 2023-01-07

3384 Stimulus-specific prediction error neurons in mouse auditory cortex

Audette, N. J.; Schneider, D. M.

10.1101/2023.01.06.523032 — neuroscience — Posted on 2023-01-07

3385 Solving the spike sorting problem with Kilosort

Pachitariu, M.; Sridhar, S.; Stringer, C.

10.1101/2023.01.07.523036 — neuroscience — Posted on 2023-01-07

3386 Microbe-induced plant drought tolerance by ABA-mediated root morphogenesis and epigenetic reprogramming of gene expression

Alwutayd, K. M.; Rawat, A. R.; Sheikh, A.; Almeida-Trapp, M.; Veluchamy, A.; Jalal, R.; Karampelias, M.; Froehlich, K.; Alzaed, W.; Tabassum, N.; Schley, T. R.; Schaeffner, A. R.; Daur, I.; Saad, M. M.; Hirt, H.

10.1101/2023.01.03.522604 — plant biology — Posted on 2023-01-07

3387 Transcriptome analysis reveals novel regulators of the Scots pine stilbene pathway

Paasela, T.; Lim, K.-J.; Pavicic, M.; Harju, A.; Venäläinen, M.; Paulin, L.; Auvinen, P.; Kärkkäinen, K.; Teeri, T. H.

10.1101/2023.01.05.522892 — plant biology — Posted on 2023-01-07

3388 MYC enhancer invasion promotes prognostic cancer type-specific gene programs through an epigenetic switch

Jakobsen, S. T.; Jensen, R.; Ravnsborg, T.; Vaagenso, C.; Einarsson, H.; Madsen, M. S.; Andersson, R. T.; Jensen, O. N.; Siersbaek, R.

10.1101/2023.01.06.522970 — genomics — Posted on 2023-01-07

3389 Distinctive and complementary roles of E2F transcription factors during plant replication stress response

Nisa, M.; Eekhout, T.; Bergis, C.; Pedroza-Garcia, J.; He, X.; Mazubert, C.; Vercauteren, I.; Brik-Chaouche, R.; Drouin-Wahbi, J.; latrasse, D.; Bergounioux, C.; Vandepoele, K.; Benhamed, M.; De Veylder, L.; Raynaud, C.

10.1101/2023.01.06.523015 — genetics — Posted on 2023-01-07

3390 Carbon Sequestration in Soils below Seaweed Farms

Duarte, C. C.; Delgado-Huertas, A. A.; Marti, E. E.; Gasser, B. B.; San Martin, I. I.; Cousteau, A. A.; Neumeyer, F. F.; Reilly-Cayten, M. M.; Boyce, J. J.; Kuwae, T. T.; Hori, M. M.; Miyajima, T. T.; Price, N. N.; Arnold, S. S.; Martinez-Ricart, A. A.; Davis, S. S.; Surugau, N. N.; Abdul, A.-J. A.; Wu, J. J.; Xi, X. X.; Chung, I. K. I.; Choi, C. G. C.; Sondak, C. F. A. C.; Albasri, H. H.; Krause-Jensen, D. D.; Bruhn, A. A.; Boderskov, T. T.; Hancke, K. K.; Funderud, J. J.; Borrero, A. A.; Pascal, F. F.; Joanne, P. P.; Ranivoarivelo, L. L.; Collins, W. T. W.; Gutierrez, J. F. J.; Riquelme, R.

10.1101/2023.01.02.522332 — ecology — Posted on 2023-01-07

3391 Loss of NR5A1 in Sertoli cells after sex determination changes their cellular identity and induces their death by anoikis

Souali-Crespo, S.; Condrea, D.; Vernet, N.; Feret, B.; Klopfenstein, M.; Grandgirard, E.; Alunni, V.; Cerciat, M.; Jung, M.; Mayere, C.; Nef, S.; Mark, M.; Chalmel, F.; Ghyselinck, N. B.

10.1101/2023.01.04.522755 — developmental biology — Posted on 2023-01-07

3392 APOBEC3F is the main source of editing identified during the 2022 outbreak of human monkeypox virus

Suspene, R.; Raymond, K. A.; Boutin, L.; Guillier, S.; Lemoine, F.; Ferraris, O.; Tournier, J.-N.; Iseni, F.; Simon-Loriere, E.; Vartanian, J.-P.

10.1101/2023.01.06.522979 — microbiology — Posted on 2023-01-07

3393 A quorum of mechano-sensing fungal consortia

Garcia-Navarrete, M.; Ruiz Sanchis, D.; Sanchez-Munoz, I.; Gonzalez-Ruiz, S.; Avdovic, M.; Atienza-Sans, S.; Wabnik, K.

10.1101/2022.10.24.513463 — microbiology — Posted on 2023-01-07

3394 Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity

Fritschi, C. J.; Anang, S.; Gong, Z.; Mohammadi, M.; Richard, J.; Bourassa, C.; Severino, K. T.; Richter, H.; Yang, D.; Chen, H.-C.; Chiu, T.-J.; Seaman, M.; Madani, N.; Abrams, C.; Finzi, A.; Hendrickson, W. A.; Sodroski, J.; Smith, A. B.

10.1101/2023.01.02.522483 — microbiology — Posted on 2023-01-07

3395 Autophagy Disruption Reduces mTORC1 Activation Leading to Retinal Ganglion Cell Neurodegeneration Associated with Glaucoma

Huang, K.-C.; Gomes, C.; Shiga, Y.; Belforte, N.; VanderWall, K. B.; Lavekar, S. S.; Fligor, C. M.; Harkin, J.; Di Polo, A.; Meyer, J. S.

10.1101/2023.01.04.522687 — neuroscience — Posted on 2023-01-07

3396 Young, but not in the Dark - the Influence of Reduced Lighting on Gait Stability in Middle-aged adults

Naaman, T.; Hayek, R.; Gutman, I.; Springer, S.

10.1101/2023.01.04.522698 — neuroscience — Posted on 2023-01-07

3397 Monosynaptic trans-collicular pathways for sensory-motor integration in the whisker system

Martin-Cortecero, J.; Isaias-Camacho, E. U.; Boztepe, B.; Ziegler, K.; Mease, R. A.; Groh, A.

10.1101/2022.08.30.505868 — neuroscience — Posted on 2023-01-07

3398 Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates the axon guidance genes robo2 and slit in Drosophila

Singh, B. N.; Tran, H.; Kramer, J.; Kirishenko, E.; Changela, N.; Wang, F.; Feng, Y.; Kumar, D.; Tu, M.; Liang, S.; Lan, J.; Bizet, M.; Fuks, F.; Steward, R.

10.1101/2023.01.03.522592 — neuroscience — Posted on 2023-01-07

3399 Relationships between competition sprint cycling power and endurance power are high across ALL durations and energetic pathways

Ferguson, H. A.; Harnish, C.; Klich, S.; Michalik, K.; Dunst, A. K.; Zhou, T.; Chase, G. J.

10.1101/2023.01.06.522987 — physiology — Posted on 2023-01-07

3400 Apelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema

Lamaa, A.; Creff, J.; Benuzzi, E.; Pujol, F.; Draia-Nicolau, T.; Nougue, M.; Verdu, L.; Morfoisse, F.; Lacazette, E.; Valet, P.; Chaput, B.; Gross, F.; Gayon, R.; Bouille, P.; Malloizel-Delaunay, J.; Bura-Riviere, A.; Prats, A.-C.; Garmy-Susini, B.

10.1101/2023.01.05.522869 — pathology — Posted on 2023-01-07

3401 VHL Mutation Drives Human Clear Cell Renal Cell Carcinoma Progression Through PI3K/AKT-Dependent Cholesteryl Ester Accumulation

Zhang, S.; He, Y.; Feng, W.; Zheng, Y.; Hu, S.; Fang, T.; Liu, Z.; Liu, J.; Yu, J.; He, A.; Gong, Y.; He, Z.; Yang, K.; Xi, Z.; Yu, W.; Zhou, L.; Yao, L.; Yue, S.

10.1101/2023.01.02.522447 — cancer biology — Posted on 2023-01-07

3402 Linear contraction of stress fibers generates cell body rotation

Okimura, C.; Akiyama, S.; Nishigami, Y.; Zaitsu, R.; Sakurai, T.; Iwadate, Y.

10.1101/2023.01.03.522661 — biophysics — Posted on 2023-01-07

3403 Conformational changes in the AdeB transmembrane efflux pump protein by amphiphilic peptide Mastoparan-B, down-regulates expression of the adeB Gene and restores antibiotics Susceptibility.

Shakibaie, M. R.; Modarresi, F.; Azizi, O.; Tadjrobehkar, O.; Ghaemi, M. M.

10.1101/2023.01.03.522678 — bioinformatics — Posted on 2023-01-07

3404 Persistent confined migration confers permanent nuclear and functional changes in migrating cells.

de Lope-Planelles, A.; Gonzalez-Novo, R.; Madrazo, E.; Zamora-Carreras, H.; Torrano, V.; Lopez-Menendez, H.; Roda-Navarro, P.; Monroy, F.; Redondo-Munoz, J.

10.1101/2023.01.05.522838 — cell biology — Posted on 2023-01-07

3405 Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity

Villarreal, O. D.; Dort, J.; Heckel, E.; Wang, Y. C.; Ragoussis, I.; Joyal, J.-S.; Dumont, N.; Richard, S.

10.1101/2023.01.03.522550 — molecular biology — Posted on 2023-01-07

3406 Flotillin-Associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes

Haro-Moreno, J. M.; Lopez-Perez, M.; Alekseev, A.; Podoliak, E.; Kovalev, K.; Gordeliy, V.; Stepanauskas, R.; Rodriguez-Valera, F.

10.1101/2023.01.04.522823 — microbiology — Posted on 2023-01-07

3407 Multi-task learning uncovers robust translation cis-regulatory features

Zheng, W.; Fong, J. H. C.; Wan, Y. K.; Chu, A. H. Y.; Huang, Y.; Wong, A. S. L.; Ho, J. W. K.

10.1101/2022.05.03.490410 — bioinformatics — Posted on 2023-01-07

3408 Adaptation to ex vivo culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner

Johnson, C. S.; Sham, K.; Belluschi, S.; Wang, X.; Lau, W.; Kaufmann, K. B.; Krivdova, G.; Calderbank, E. F.; Mende, N.; McLeod, J.; Mantica, G.; Williams, M. J.; Grey-Wilson, C.; Drakopoulos, M.; Sinha, S.; Diamanti, E.; Basford, C.; Green, A. R.; Wilson, N. K.; Howe, S. J.; Dick, J. E.; Gottgens, B.; Francis, N.; Laurenti, E.

10.1101/2022.11.17.516906 — cell biology — Posted on 2023-01-07

3409 Degeneracy and stability in neural circuits of dopamine and serotonin neuromodulators: A theoretical consideration

Behera, C. K.; Joshi, A.; Wang, D.-H.; Sharp, T.; Wong-Lin, K.

10.1101/2020.09.25.313999 — neuroscience — Posted on 2023-01-06

3410 Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis

Killinger, B. A.; Brundin, P.; Kordower, J. H.; Mercado, G.; Choi, S. G.; Chu, Y.; Tittle, T.

10.1101/2021.12.22.473905 — neuroscience — Posted on 2023-01-06

3411 Loss of secondary motor cortex neurons in chronic neuropathic pain

Das Gupta, A.; Zheng, H.; John, J.; Kaushalya, S.; Asan, L.; Beretta, C.; Kuner, R.; Knabbe, J.; Kuner, T.

10.1101/2023.01.05.522932 — neuroscience — Posted on 2023-01-06

3412 The Cortical Representation of Language Timescales is Shared between Reading and Listening

Chen, C.; Dupre la Tour, T.; Gallant, J.; Klein, D.; Deniz, F.

10.1101/2023.01.06.522601 — neuroscience — Posted on 2023-01-06

3413 D-type K+ current controls the function of electrically coupled neurons in a species-specific fashion

Dapino, A.; Davoine, F.; Curti, S.

10.1101/2023.01.06.523023 — neuroscience — Posted on 2023-01-06

3414 Defining protein variant functions using high-complexity mutagenesis libraries and enhanced mutant detection software ASMv1.0

10.1101/2021.06.16.448102 — systems biology — Posted on 2023-01-06

3415 Unified Tumor Growth Mechanisms from Multimodel Inference and Dataset Integration

Beik, S. P.; Harris, L. A.; Kochen, M. A.; Sage, J.; Quaranta, V.; Lopez, C. F.

10.1101/2022.07.22.500696 — systems biology — Posted on 2023-01-06

3416 MODELING POLARITY SITE MOVEMENT IN YEAST VIA CALCIUM-MEDIATED REGULATION OF GAP ACTIVITY

Parikh, V.

10.1101/2022.12.20.521256 — systems biology — Posted on 2023-01-06

3417 Extremely-fast construction and querying of compacted and colored de Bruijn graphs with GGCAT

Cracco, A.; Tomescu, A. I.

10.1101/2022.10.24.513174 — bioinformatics — Posted on 2023-01-06

3418 Dashing 2: genomic sketching with multiplicities and locality-sensitive hashing

Baker, D. N.; Langmead, B.

10.1101/2022.10.16.512384 — bioinformatics — Posted on 2023-01-06

3419 Statistically Consistent Rooting of Species Trees under the Multi-Species Coalescent Model

Tabatabaee, Y.; Roch, S.; Warnow, T.

10.1101/2022.10.26.513897 — bioinformatics — Posted on 2023-01-06

3420 Somatic mutation but not aneuploidy differentiates lung cancer in never-smokers and smokers.

Moorthi, S.; Paguirigan, A.; Ko, M.; Pettinger, M.; Hoge, A. C. H.; Nag, A.; Patel, N. A.; Wu, F.; Sather, C.; Fitzgibbon, M. P.; Thorner, A. R.; Anderson, G. L.; Ha, G.; Berger, A. H.

10.1101/2023.01.05.522947 — genomics — Posted on 2023-01-06

3421 Sex-biased infections scale to population impacts for an emerging wildlife disease

Kailing, M. J.; Hoyt, J. R.; White, J. P.; Kaarakka, H. M.; Redell, J. A.; Leon, A. E.; Rocke, T. E.; DePue, J. E.; Scullon, W. H.; Parise, K. L.; Foster, J. T.; Kilpatrick, A. M.; Langwig, K. E.

10.1101/2022.07.29.502066 — ecology — Posted on 2023-01-06

3422 Biodiversity-ecosystem function relationships change in sign and magnitude across the Hill diversity spectrum

Roswell, M.; Harrison, T.; Genung, M.

10.1101/2022.09.30.510130 — ecology — Posted on 2023-01-06

3423 High-throughput single molecule tracking identifies drug interactions and cellular mechanisms

McSwiggen, D. T.; Liu, H.; Tan, R.; Agramunt Puig, S.; Akella, L. B.; Berman, R.; Bretan, M.; Chen, H.; Darzacq, X.; Ford, K.; Godbey, R.; Gonzalez, E.; Hanuka, A.; Heckert, A.; Ho, J. J.; Johnson, S. L.; Kelso, R.; Klammer, A.; Li, J.; Lin, K.; Margolin, B.; McNamara, P.; Meyer, L.; Pierce, S. E.; Sule, A.; Tang, Y.; Anderson, D. J.; Beck, H.

10.1101/2023.01.05.522916 — cell biology — Posted on 2023-01-06

3424 Circadian desynchronization attenuates information throughput independent of daily rhythms in prefrontal cortex pyramidal neurons in mice

Roberts, B. L.; Karatsoreos, I. N.

10.1101/2022.01.27.478010 — neuroscience — Posted on 2023-01-06

3425 Newly repopulated spinal cord microglia exhibit a unique transcriptome and coincide with sex-independent pain resolution

Donovan, L. J.; Bridges, C. M.; Nippert, A. R.; Wang, M.; Wu, S.; Forman, T. E.; Haight, E. S.; Huck, N. A.; Jordan, C. E.; Gardner, A. S.; Nair, R. V.; Tawfik, V. L.

10.1101/2022.12.20.521295 — neuroscience — Posted on 2023-01-06

3426 The human language system, including its inferior frontal component in 'Broca's area', does not support music perception

Chen, X.; Affourtit, J.; Ryskin, R.; Regev, T. I.; Norman-Haignere, S.; Jouravlev, O.; Malik-Moraleda, S.; Kean, H.; Varley, R.; Fedorenko, E.

10.1101/2021.06.01.446439 — neuroscience — Posted on 2023-01-06

3427 Somatostatin-expressing neurons in the ventral tegmental area innervate specific forebrain regions and are involved in the stress response

Nagaeva, E.; Schafer, A.; Linden, A.-M.; Elsila, L. V.; Ryazantseva, M.; Umemori, J.; Egorova, K.; Korpi, E. R.

10.1101/2023.01.06.522982 — neuroscience — Posted on 2023-01-06

3428 The Field-Dependent Nature of PageRank Values in Citation Networks

Heil, B. J.; Greene, C. S.

10.1101/2023.01.05.522943 — scientific communication and education — Posted on 2023-01-06

3429 Genomic evolution of non-small cell lung cancer patient-derived xenograft models

Hynds, R. E.; Huebner, A.; Pearce, D. R.; Akarca, A. U.; Moore, D. A.; Ward, S.; Gowers, K. H. C.; Karasaki, T.; Hill, M. S.; Al Bakir, M.; Wilson, G. A.; Pich, O.; Sivakumar, M.; Ben Aissa, A.; Gronroos, E.; Chandrasekharan, D.; Kolluri, K. K.; Towns, R.; Wang, K.; Cook, D. E.; Bosshard-Carter, L.; Naceur-Lombardelli, C.; Rowan, A. J.; Veeriah, S.; Litchfield, K.; Quezada, S. A.; Janes, S. M.; Jamal-Hanjani, M.; Marafioti, T.; TRACERx Consortium, ; McGranahan, N.; Swanton, C.

10.1101/2023.01.06.521078 — cancer biology — Posted on 2023-01-06

3430 Enhanced neuroimaging with a calcium sensor in the live adult Drosophila Melanogaster brain using closed-loop adaptive optics light-sheet microscopy

Hubert, A.; Farkouh, G.; Harms, F.; Veilly, C.; Imperato, S.; Mercier, M.; Loriette, V.; Rouyer, F.; Fragola, A.

10.1101/2023.01.06.522997 — biophysics — Posted on 2023-01-06

3431 Unusual actin-binding mechanism and the role of profilin in actin dynamics of trypanosomatid parasites

Vizcaino-Castillo, A.; Kotila, T.; Kogan, K.; Yanase, R.; Como, J.; Antenucci, L.; Michelot, A.; Sunter, J. D.; Lappalainen, P.

10.1101/2023.01.06.522972 — biochemistry — Posted on 2023-01-06

3432 To design or not to design? Comparison of beetle ultraconserved element probe set utility based on phylogenetic distance, breadth, and method of probe design

Gustafson, G.; Glynn, R.; Short, A.; Tarasov, S.; Gunter, N.

10.1101/2023.01.06.522983 — evolutionary biology — Posted on 2023-01-06

3433 Thyroid hormone-dependent apoptosis during metamorphosis in Ciona robusta involves both bilaterian-ancestral and vertebrate-derived processes

Martinand-Mari, C.; Godefroy, N.; Le Goff, E.; Pan, Q.; Baghdiguian, S.; Debiais-Thibaud, M.

10.1101/2023.01.06.522990 — evolutionary biology — Posted on 2023-01-06

3434 The possible copepod link between kelp forests, the pelagic ecosystem and deep-sea carbon sequestration

Kvile, K. O.; Angles d'Auriac, M.; Altin, D.; Olsen, R. E.; Hancke, K.

10.1101/2023.01.06.523004 — ecology — Posted on 2023-01-06

3435 A parametric model for estimating the timing and intensity of animal migration

Thompson, P. R.; Harrington, P. D.; Mallory, C. D.; Lele, S. R.; Bayne, E. M.; Derocher, A. E.; Edwards, M. A.; Campbell, M.; Lewis, M. A.

10.1101/2023.01.05.522924 — ecology — Posted on 2023-01-06

3436 Sniffer beetles: Odor imaging reveals congeneric herbivores identify their congeneric hostplants based on differential olfactory perceptions

Binayak, G.; Deshpande, A.; Dahanukar, N.; Ingale, P.; Subaharan, K.; Munikrishnappa, V. K. T.; Ghate, H.; Pandit, S.

10.1101/2023.01.06.522974 — ecology — Posted on 2023-01-06

3437 Targeting the deNEDDylating enzyme NEDP1 to ameliorate ALS phenotypes through Stress Granules dissolution

Kassouf, T.; Shrivastava, R.; Meszka, I.; Bailly, A.; Polanowska, J.; Trauchessec, H.; Mandrioli, J.; Carra, S.; Xirodimas, D.

10.1101/2023.01.06.522988 — cell biology — Posted on 2023-01-06

3438 Neural characterization of the "totonou" state associated with sauna use

Chang, M.; Ibaraki, T.; Naruse, Y.; Imamura, Y.

10.1101/2023.01.06.522959 — neuroscience — Posted on 2023-01-06

3439 Thermodynamic limitations on brain oxygen metabolism: physiological implications

Buxton, R. B.

10.1101/2023.01.06.522942 — neuroscience — Posted on 2023-01-06

3440 A Transcriptional Cofactor Regulatory Network for the C. elegans Intestine

Walhout, M.; Horowitz, B. B.; Nanda, S.

10.1101/2023.01.05.522920 — systems biology — Posted on 2023-01-06

3441 Zinc nano-fertilization enhances wheat productivity and biofortification

Yadav, A.; Bana, R.; Krishnan, P.; Kundu, M.; Choudhary, A. K.; Shivay, Y. S.; Meena, S. L.; Begam, S.; Godara, S.; Ranjan, R.; Kumar, S.; Yadav, S.; Nain, M. S.; Singh, T.; Yadav, A.; Raj, R.

10.1101/2023.01.06.522993 — plant biology — Posted on 2023-01-06

3442 Transcription factors mediating regulation of photosynthesis

Halpape, W.; Wulf, D.; Verwaaijen, B.; Stasche, A. S.; Zenker, S.; Sielemann, J.; Tschikin, S.; Viehoever, P.; Sommer, M.; Weber, A. P.; Delker, C.; Eisenhut, M.; Braeutigam, A.

10.1101/2023.01.06.522973 — plant biology — Posted on 2023-01-06

3443 Revealing how memory shapes time-dependent computational processes in plant tropisms

Riviere, M.; Meroz, Y.

10.1101/2023.01.06.522981 — plant biology — Posted on 2023-01-06

3444 Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM

Bergh, C.; Rovsnik, U.; Howard, R. J.; Lindahl, E.

10.1101/2023.01.06.523006 — biophysics — Posted on 2023-01-06

3445 A self-inactivating invertebrate opsin with resistance to retinal depletion optically drives biased signaling toward Gβγ-dependent ion channel modulation

Tsukamoto, H.; Kubo, Y.

10.1101/2023.01.05.522954 — biophysics — Posted on 2023-01-06

3446 Effects of Alzheimer's Disease Drug Candidates on Disordered Aβ42 Dissected by Comparative Markov State Analysis (CoVAMPnet)

Marques, S. M.; Kouba, P.; Legrand, A.; Sedlar, J.; Disson, L.; Planas-Iglesias, J.; Sanusi, Z.; Kunka, A.; Damborsky, J.; Pajdla, T.; Prokop, Z.; Mazurenko, S.; Sivic, J.; Bednar, D.

10.1101/2023.01.06.523007 — biophysics — Posted on 2023-01-06

3447 ViralConsensus: A fast and memory-efficient tool for calling viral consensus genome sequences directly from read alignment data

Moshiri, N.

10.1101/2023.01.05.522928 — bioinformatics — Posted on 2023-01-06

3448 RabbitVar: ultra-fast and accurate somatic small-variant calling on multi-core architectures

Zhang, H.; Song, H.; Yin, Z.; Chang, Q.; Wei, Y.; Niu, B.; Schmidt, B.; Liu, W.

10.1101/2023.01.06.522980 — bioinformatics — Posted on 2023-01-06

3449 Sterol derivative binding to the orthosteric site causes conformational changes in an invertebrate Cys-loop receptor

De Gieter, S.; Wijckmans, E.; Pasini, D.; Ulens, C.; Efremov, R. G.

10.1101/2023.01.06.523009 — biochemistry — Posted on 2023-01-06

3450 A strongly improved assembly of the pearl millet reference genome using OxfordNanopore long reads and optical mapping

Salson, M.; Orjuela, J.; Mariac, C.; Zekraoui, L.; Couderc, M.; Arribat, S.; Rodde, N.; Faye, A.; Kane, N.; Tranchant-Dubreuil, C.; Vigouroux, Y.; Berthouly-Salazar, C.

10.1101/2023.01.06.522873 — genomics — Posted on 2023-01-06

3451 Ultra-fast genome-wide inference of pairwise coalescence times

Schweiger, R.; Durbin, R.

10.1101/2023.01.06.522935 — genetics — Posted on 2023-01-06

3452 A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bug Cimex lectularius

Haberkorn, C.; David, J.-P.; Henri, H.; Delpuech, J.-M.; Lasseur, R.; Vavre, F.; Varaldi, J.

10.1101/2023.01.06.522975 — evolutionary biology — Posted on 2023-01-06

3453 RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1alpha

Dumesic, P. A.; Wilensky, S. E.; Bose, S.; Van Vranken, J. G.; Spiegelman, B. M.

10.1101/2023.01.06.522985 — cell biology — Posted on 2023-01-06

3454 Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome

Cao, F.; Deliz-Aguirre, R.; Gerpott, F. H. U.; Ziska, E.; Taylor, M. J.

10.1101/2023.01.06.522894 — cell biology — Posted on 2023-01-06

3455 Mechanistic insight into substrate specificity of plant glucosinolate transporters

Kanstrup, C.; Wulff, N.; Pena-Varas, C.; Jorgensen, M. E.; Bang-Sorensen, R.; Crocoll, C.; Jorgensen, F. S.; Ramirez, D.; Dreyer, I.; Mirza, O.; Nour-Eldin, H. H.

10.1101/2023.01.06.522984 — molecular biology — Posted on 2023-01-06

3456 A bioinformatics screen reveals Hox and chromatin remodeling factors at the Drosophila histone locus

Hodkinson, L. J.; Smith, C.; Comstra, H. S.; Albanese, E. H.; Ajani, B. A.; Arsalan, K.; Perez Daisson, A.; Forrest, K. B.; Fox, E. H.; Guerette, M. R.; Khan, S.; Koenig, M. P.; Lam, S.; Lewandowski, A. S.; Mahoney, L. J.; Manai, N.; Migaly, J.; Miller, B. A.; Milloway, O.; Ngo, V. D.; Oey, N. F.; Punjani, T. A.; SiMa, H.; Zeng, H.; Schmidt, C. A.; Rieder, L. E.

10.1101/2023.01.06.523008 — molecular biology — Posted on 2023-01-06

3457 ATG5 selectively engages virus-tethered BST2/Tetherin in an LC3C-associated pathway

Judith, D.; Versapuech, M.; Bejjani, F.; Palaric, M.; Verlhac, P.; Kuster, A.; Lepont, L.; Gallois-Montbrun, S.; Janvier, K.; Berlioz-Torrent, C.

10.1101/2023.01.06.522978 — microbiology — Posted on 2023-01-06

3458 Multi-scale transcriptome unveils spatial organisation and temporal dynamics of Bacillus subtilis biofilms

Dergham, Y.; Le Coq, D.; Nicolas, P.; Deschamps, J.; Huillet, E.; Sanchez-Vizuete, P.; Hamze, K.; Briandet, R.

10.1101/2023.01.06.522868 — microbiology — Posted on 2023-01-06

3459 Zika virus infection induces IL-1β-mediated inflammatory responses by macrophages in the brain of an adult mouse model

Jeong, G. U.; Lee, S.; Kim, D. Y.; Lyu, J.; Yoon, G. Y.; Ko, J.; Kwon, Y.-C.

10.1101/2023.01.05.522967 — microbiology — Posted on 2023-01-06

3460 Identification of protein secretion systems in bacterial genomes using MacSyFinder version 2.

Abby, S. S.; Denise, R.; Rocha, E. P.

10.1101/2023.01.06.522999 — microbiology — Posted on 2023-01-06

3461 Leafhopper transmits soybean stay-green associated virus to legume plants

Yin, J.; Hu, Z.; Xu, S.; Hong, X.; Qiu, Y.; Cheng, X.; Wang, L.; Sheng, W.; Zhi, H.; Li, K.; Xu, K.

10.1101/2023.01.05.522956 — microbiology — Posted on 2023-01-06

3462 Human CCR6+ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity

Singh, S. P.; Parween, F.; Edara, N.; Zhang, H. H.; Chen, J.; Otaizo-Carrasquero, F.; Cheng, D.; Oppenheim, N. A.; Ransier, A.; Zhu, W.; Shamsaddini, A.; Gardina, P. J.; Darko, S. W.; Singh, T. P.; Douek, D. C.; Myers, T. G.; Farber, J. M.

10.1101/2023.01.05.522630 — immunology — Posted on 2023-01-06

3463 Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme

Chan, A. H.; Vezyrgiannis, K.; Von Pein, J. B.; Wang, X.; Labzin, L. I.; Boucher, D.; Schroder, K.

10.1101/2023.01.05.522955 — immunology — Posted on 2023-01-06

3464 Automated Enrichment of Phosphotyrosine Peptides for High-Throughput Proteomics

Chang, A. T.; Leutert, M.; Rodriguez-Mias, R.; Villen, J.

10.1101/2023.01.05.522335 — systems biology — Posted on 2023-01-06

3465 Ultrasensitive Proteomics Depicted an In-depth Landscape for Mouse Embryo

Gu, L.; Li, X. M.; Zhu, W. C.; Shen, Y.; Wang, Q. Q.; Zhang, H. P.; Li, J. Q.; Li, Z. Y.; Liu, Z.; Li, C.; Wang, H.

10.1101/2023.01.06.523005 — systems biology — Posted on 2023-01-06

3466 Joint effects of social interactions and environmental challenges on physiology, internal microbiome, and reproductive performance in tree swallows (Tachycineta bicolor).

Taff, C. C.; McNew, S. M.; Zimmer, C.; Uehling, J. J.; Houtz, J. L.; Ryan, T. A.; Chang van Oordt, D.; Injaian, A. S.; Vitousek, M. N.

10.1101/2023.01.05.522952 — physiology — Posted on 2023-01-06

3467 Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma

Kinnaman, M. D.; Zaccaria, S.; Makohon-Moore, A.; Arnold, B.; Levine, M.; Gundem, G.; Ossa, J. E. A.; Glodzik, D.; Sanchez, M. I. R.; Bouvier, N.; Li, S.; Stockfisch, E.; Dunigan, M.; Cobbs, C.; Bhanot, U.; You, D.; Ortiz, M. V.; O'Donohue, T.; Slotkin, E.; Wexler, L. H.; Cruz, F. S. D.; Hameed, M.; Bender, J. L. G.; Tap, W. D.; Meyers, P.; Papaemmanuil, E.; Kung, A. L.; Iacobuzio-Donahue, C. A.

10.1101/2023.01.05.522765 — cancer biology — Posted on 2023-01-06

3468 High-yield, ligation-free assembly of DNA constructs with nucleosome positioning sequence repeats for single molecule manipulation assays

Lin, Y.-Y.; Brouns, T.; Kolbeck, P. J.; Vanderlinden, W.; Lipfert, J.

10.1101/2023.01.05.522917 — biophysics — Posted on 2023-01-06

3469 ConDoR: Tumor phylogeny inference with a copy-number constrained mutation loss model

Sashittal, P.; Zhang, H.; Iacobuzio-Donahue, C. A.; Raphael, B.

10.1101/2023.01.05.522408 — bioinformatics — Posted on 2023-01-06

3470 Heterogeneous pseudobulk simulation enables realistic benchmarking of cell-type deconvolution methods

Hu, M.; Chikina, M.

10.1101/2023.01.05.522919 — bioinformatics — Posted on 2023-01-06

3471 Osseointegration of functionally-graded Ti6Al4V porous implants: Histology of the pore network

Deering, J.; Mahmoud, D.; Rier, E.; Lin, Y.; Pereira, A. C. d. N.; Titotto, S.; Fang, Q.; Wohl, G. R.; Deng, F.; Grandfield, K.; Elbestawi, M. A.; Chen, J.

10.1101/2023.01.05.521963 — bioengineering — Posted on 2023-01-06

3472 Graph Convolutional learning of Multimodal Brain Connectome Data for Schizophrenia Classification

Ghosh, S.; Bhargava, E.; Lin, C.-T.; Nagarajan, S. S.

10.1101/2023.01.05.522960 — bioengineering — Posted on 2023-01-06

3473 A Novel Protein for the Bioremediation of Gadolinium Waste

Lee, H. D.; Grady, C. J.; Krell, K.; Strebeck, C.; Good, N. M.; Martinez-Gomez, N. C.; Gilad, A.

10.1101/2023.01.05.522788 — bioengineering — Posted on 2023-01-06

3474 Phenotypic subtyping via contrastive learning

Gorla, A.; Sankararaman, S.; Burchard, E.; Flint, J.; Zaitlen, N.; Rahmani, E.

10.1101/2023.01.05.522921 — genomics — Posted on 2023-01-06

3475 Leveraging family data to design Mendelian Randomization that is provably robust to population stratification

LaPierre, N.; Fu, B.; Turnbull, S.; Eskin, E.; Sankararaman, S.

10.1101/2023.01.05.522936 — genetics — Posted on 2023-01-06

3476 Assessment of distant-site rescue elements for CRISPR toxin-antidote gene drives

Chen, J.; Xu, X.; Champer, J.

10.1101/2023.01.06.522951 — genetics — Posted on 2023-01-06

3477 Whole Genomes Reveal Evolutionary Relationships and Mechanisms Underlying Gene-Tree Discordance in Neodiprion Sawflies

Herrig, D. K.; Vertacnik, K. L.; Ridenbaugh, R. D.; Everson, K. M.; Sim, S. B.; Geib, S. M.; Weisrock, D.; Linnen, C. R.

10.1101/2023.01.05.522922 — evolutionary biology — Posted on 2023-01-06

3478 Ongoing amphibian trade into the United States threatens salamander biodiversity

Connelly, P. J.; Ross, N.; Stringham, O. C.; Eskew, E. A.

10.1101/2023.01.05.522946 — ecology — Posted on 2023-01-06

3479 Environmental constraints can explain clutch size differences between urban and forest blue tits (Cyanistes caeruleus): insights from an egg removal experiment

Pitt, M. D.; Capilla-Lasheras, P.; Alhowiti, N. S. S.; Branston, C.; Carlon, E.; Boonekamp, J.; Dominoni, D. M.

10.1101/2023.01.05.522710 — ecology — Posted on 2023-01-06

3480 Durotaxis bridges phase transition as a function of tissue stiffness in vivo

Zhu, M.; Gu, B.; Thomas, E. C.; Tao, H.; Yung, T.; Zhang, K.; Rossant, J.; Sun, Y.; Hopyan, S.

10.1101/2023.01.05.522913 — developmental biology — Posted on 2023-01-06

Price, C. A.

10.1101/2023.01.05.522893 — developmental biology — Posted on 2023-01-06

3482 Evaluation Of Effect Of Bacteria On The Surface Of The Dental Implant

George, A. S.; S, S.; NP, M.; R, S.; N, T.

10.1101/2023.01.05.522965 — microbiology — Posted on 2023-01-06

3483 The macrophage genetic cassette inr/dtor/pvf2 is a nutritional status checkpoint for developmental timing.

Juarez-Carreno, S.; Geissmann, F.

10.1101/2023.01.05.522883 — immunology — Posted on 2023-01-06

3484 The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis

Sikder, M. A. A.; Rashid, R. B.; Ahmed, T.; Sebina, I.; Howard, D. R.; Ullah, M. A.; Rahman, M. M.; Lynch, J. P.; Curren, B.; Werder, R. B.; Simpson, J.; Bissell, A.; Morrison, M.; Walpole, C.; Radford, K. J.; Kumar, V.; Woodruff, T. M.; Tan, H.; Ali, A.; Kaiko, G. E.; Upham, J. W.; Hoelzle, R. D.; O Cuiv, P.; Holt, P. G.; Dennis, P. G.; Phipps, S.

10.1101/2023.01.05.522516 — immunology — Posted on 2023-01-06

3485 Cortical projection to the pedunculopontine nucleus subpopulation for the Go/STOP signal modulation of muscle tone and locomotion

Dautan, D.

10.1101/2023.01.05.522181 — neuroscience — Posted on 2023-01-06

3486 An entorhinal-like region in food-caching birds

Applegate, M. C.; Gutnichenko, K. S.; Mackevicius, E. L.; Aronov, D.

10.1101/2023.01.05.522940 — neuroscience — Posted on 2023-01-06

3487 Decomprolute: A benchmarking platform designed for multiomics-based tumor deconvolution

Feng, S.; Calinawan, A. P.; Pugliese, P.; Wang, P.; Ceccarelli, M.; Petralia, F.; Gosline, S. J.

10.1101/2023.01.05.522902 — cancer biology — Posted on 2023-01-06

3488 Functional genomic analysis of adult and pediatric brain tumor isolates

Hoellerbauer, P.; Biery, M.; Arora, S.; Rao, Y.; Girard, E.; Mitchell, K.; Dighe, P.; Kufeld, M.; Kuppers, D.; Herman, J.; Holland, E.; Soroceanu, L.; Vitanza, N.; Olson, J.; Pritchard, J.; PADDISON, P.

10.1101/2023.01.05.522885 — cancer biology — Posted on 2023-01-06

3489 Fracture in Living Cell Monolayers

Duque, J.; Bonfanti, A.; Fouchard, J.; Ferber, E.; Harris, A.; Kabla, A.; Charras, G.

10.1101/2023.01.05.522736 — biophysics — Posted on 2023-01-06

3490 The Use of Class Imbalanced Learning Methods on ULSAM Data to Predict the Case-Control Status in Genome-Wide Association Studies

Oztornaci, R. O.; Syed, H.; Morris, A.; Tasdelen, B.

10.1101/2023.01.05.522884 — bioinformatics — Posted on 2023-01-06

3491 When Geometric Deep Learning Meets Pretrained Protein Language Models

Wu, F.; Radev, D.; Xu, J.

10.1101/2023.01.05.522958 — bioinformatics — Posted on 2023-01-06

3492 The probability of edge existence due to node degree: a baseline for network-based predictions

Zietz, M.; Himmelstein, D. S.; Kloster, K.; Williams, C.; Nagle, M. W.; Greene, C. S.

10.1101/2023.01.05.522939 — bioinformatics — Posted on 2023-01-06

3493 Harnessing antimicrobial peptide genes to expedite disease-resistant enhancement in aquaculture: Transgenesis and genome editing

Wang, J.; Cheng, Y.

10.1101/2023.01.05.522886 — bioengineering — Posted on 2023-01-06

3494 Omicron Spike Protein Is Vulnerable to Reduction

Stagljar, I.; Yao, Z.; Geng, B.; Marcon, E.; Pu, S.; Tang, H.; Merluza, J.; Bello, A.; Snider, J.; Lu, P.; Wood, H.

10.1101/2023.01.06.522977 — biochemistry — Posted on 2023-01-06

3495 Comparison of SARS-CoV-2 entry inhibitors based on ACE2 receptor or engineered Spike-binding peptides

Llewellyn, G. N.; Chen, H.-Y.; Rogers, G. L.; Huang, X.; Sell, P.; Henley, J. E.; Cannon, P. M.

10.1101/2023.01.05.522964 — microbiology — Posted on 2023-01-06

3496 Dynamics of temporal attention revealed by continuous tracking of visual cortical responses

Denison, R. N.; Tian, K.; Heeger, D. J.; Carrasco, M.

10.1101/2022.11.18.517084 — neuroscience — Posted on 2023-01-06

3497 Adenoviral chromatin organization primes for early gene activation

Schwartz, U.; Komatsu, T.; Huber, C.; Lagadec, F.; Baumgartl, C.; Silberhorn, E.; Nuetzel, M.; Rayne, F.; Basyuk, E.; Bertrand, E.; Rehli, M.; Wodrich, H.; Laengst, G.

10.1101/2020.07.07.190926 — cell biology — Posted on 2023-01-06

3498 Epigenetically silencing gluconeogenic enzyme PCK1 by EZH2 promotes renal tubulointerstitial fibrosis

Wu, M.; Chen, D.; Wang, Y.; Lin, P.; Yang, F.; Lin, J.; Tan, B.; Sheng, G.; Yang, X.; Huang, D.; Ye, C.

10.1101/2022.10.31.514497 — molecular biology — Posted on 2023-01-06

3499 Substrate binding and lipid-mediated allostery in the human organic anion transporter 1 at the atomic-scale

Janaszkiewicz, A.; Toth, A.; Faucher, Q.; Arnion, H.; Vedrenne, N.; Barin-Le Guellec, C.; Marquet, P.; Di Meo, F.

10.1101/2022.07.14.500056 — pharmacology and toxicology — Posted on 2023-01-06

3500 Reverse Correlation Uncovers More Complete Tinnitus Spectra

Hoyland, A.; Barnett, N. V.; Roop, B. W.; Alexandrou, D.; Caplan, M.; Mills, J.; Parrell, B.; Chari, D. A.; Lammert, A. C.

10.1101/2022.12.23.521795 — bioengineering — Posted on 2023-01-06

3501 A Modular Approach to Active Focus Stabilization for Fluorescence Microscopy

van den Berg, B.; Van den Eynde, R.; Amouroux, B.; Mueller, M.; Dedecker, P.; Vandenberg, W.

10.1101/2020.09.22.308197 — biochemistry — Posted on 2023-01-06

3502 Heterochromatin and RNAi act independently to ensure genome stability in Mucorales human fungal pathogens

Navarro-Mendoza, M. I.; Perez-Arques, C.; Heitman, J.

10.1101/2022.12.01.518749 — genetics — Posted on 2023-01-06

3503 The Verticillium longisporum phospholipase VlsPLA2 is a virulence factor targets host nuclei and modulates plant immunity

Rafiei, V.; Velez, H.; Piombo, E.; Dubey, M.; Tzelepis, G.

10.1101/2022.03.19.484916 — microbiology — Posted on 2023-01-06

3504 Modulatory dynamics of periodic and aperiodic activity in respiration-brain coupling

Kluger, D. S.; Forster, C.; Abbasi, O.; Chalas, N.; Villringer, A.; Gross, J.

10.1101/2022.07.14.500026 — neuroscience — Posted on 2023-01-06

3505 Endophytic fungi related to the ash dieback causal agent encode signatures of pathogenicity on European ash

Rafiqi, M.; Kosawang, C.; Peers, J. A.; Jelonek, L.; Yvanne, H.; McMullan, M.; Nielsen, L. R.

10.1101/2023.01.04.522732 — plant biology — Posted on 2023-01-06

3506 Metabolic engineering of anthocyanin pathway in Artemisia annua cells does not exclude the expression of artemisinin pathway

Judd, R.; Dong, Y.; Sun, X.; Zhu, Y.; Li, M.; Xie, D.-Y.

10.1101/2023.01.05.522882 — plant biology — Posted on 2023-01-06

3507 The Resolvin D2-GPR18 Axis Enhances Bone Marrow Function and Limits Hepatic Fibrosis in Aging

Fitzgerald, H.; Bonin, J. L.; Sadhu, S.; Lipscomb, M.; Biswas, N.; Decker, C.; Nabage, M.; Bossardi, R.; Marinello, M.; Hebe Mena, A.; Gilliard, K.; Spite, M.; Adam, A.; MacNamara, K. C.; Fredman, G.

10.1101/2023.01.05.522881 — physiology — Posted on 2023-01-06

3508 Heterogeneity of Glycan Biomarker Clusters as an Indicator of Recurrence in Pancreatic Cancer

Haab, B. B.; Allen, P.; Shi, C.; Braak, S.; Klamer, Z.; Gao, C.

10.1101/2023.01.05.522607 — cancer biology — Posted on 2023-01-06

3509 Segmenting functional tissue units across human organs using community-driven development of generalizable machine learning algorithms

Jain, Y.; Godwin, L. L.; Joshi, S.; Mandarapu, S.; Le, T.; Lindskog, C.; Lundberg, E.; Börner, K.

10.1101/2023.01.05.522764 — bioinformatics — Posted on 2023-01-06

3510 Deep learning-driven fragment ion series classification enables highly precise and sensitive de novo peptide sequencing

Klaproth-Andrade, D.; Hingerl, J.; Smith, N. H.; Trauble, J.; Wilhelm, M.; Gagneur, J.

10.1101/2023.01.05.522752 — bioinformatics — Posted on 2023-01-06

3511 UFMTrack: Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

Vladymyrov, M.; Marchetti, L.; Aydin, S.; Soldati, S. G. N.; Mossu, A.; Pal, A.; Gueissaz, L.; Ariga, A.; Engelhardt, B.

10.1101/2023.01.04.522827 — immunology — Posted on 2023-01-06

3512 Identification and characterization of metabolic subtypes of endometrial cancer using systems-level approach

Srivastava, A.; Vinod, P. K.

10.1101/2023.01.05.522818 — systems biology — Posted on 2023-01-06

3513 Realistic simulation of time-course measurements in systems biology

Egert, J.; Kreutz, C.

10.1101/2023.01.05.522854 — systems biology — Posted on 2023-01-06

3514 Artificial nanovesicles for dsRNA delivery in spray induced gene silencing for crop protection

Qiao, L.; Nino Sanchez, J.; Hamby, R.; Capriotti, L.; Chen, A.; Mezzetti, B.; Jin, H.

10.1101/2023.01.03.522662 — plant biology — Posted on 2023-01-06

3515 Distinct functions of TIR1 and AFB1 receptors in auxin signalling

Chen, H.; Li, L.; Qi, L.; Friml, J.

10.1101/2023.01.05.522749 — plant biology — Posted on 2023-01-06

3516 Wheat plant height locus RHT25 encodes a PLATZ transcription factor that interacts with DELLA (RHT1)

Zhang, J.; Li, C.; Zhang, W.; Zhang, X.; Mo, Y.; Tranquilli, G. E.; Vanzetti, L. S.; Dubcovsky, J.

10.1101/2023.01.05.522836 — plant biology — Posted on 2023-01-06

3517 The FIBRILLIN multigene family in tomato, their roles in plastoglobuli structure and metabolism

Almeida, J.; Perez-Fons, L.; Drapal, M.; Liew, K.; Fraser, P. D.

10.1101/2023.01.05.522848 — plant biology — Posted on 2023-01-06

3518 Spatiotemporal distribution of ROS production, delivery and utilization in Arabidopsis root hairs

Kubenova, L.; Haberland, J.; Dvorak, P.; Samaj, J.; Ovecka, M.

10.1101/2023.01.05.522872 — plant biology — Posted on 2023-01-06

3519 Collagen remodeling leads to inflammation-free expansion of periprostatic adipose tissue and promotes prostate cancer progression

Esteve, D.; Toulet, A.; Roumiguie, M.; Bu, D.; Pericart, S.; Belles, C.; Manceau, C.; Houel, C.; Ducoux-Petit, M.; Van Acker, N.; Dauvillier, S.; Jia, Y.; Franchet, C.; Doumerc, N.; Thoulouzan, M.; Le Gonidec, S.; Valet, P.; Malavaud, B.; Burlet-Schiltz, O.; Bouloumie, A.; Scherer, P. E.; Milhas, D.; Muller, C.

10.1101/2023.01.05.522843 — cancer biology — Posted on 2023-01-06

3520 Accurate and Rapid Detection of Peritoneal Metastasis from Gastric Cancer by AI-assisted Stimulated Raman Cytology

Chen, X.; Wu, Z.; He, Y.; Hao, Z.; Wang, Q.; Zhou, K.; Zhou, W.; Wang, P.; Shan, F.; Li, Z.; Ji, J.; Fan, Y.; Li, Z.; Yue, S.

10.1101/2023.01.05.522829 — biophysics — Posted on 2023-01-06

3521 CAT PETR: A Graphical User Interface for Differential Analysis of Phosphorylation Data

Flanagan, K.; Av-Gay, Y.; Pelech, S.; Dao Duc, K.

10.1101/2023.01.04.522665 — bioinformatics — Posted on 2023-01-06

3522 Minimal Positional Substring Cover: A Haplotype Threading Alternative to Li & Stephens Model

Sanaullah, A.; Zhi, D.; Zhang, S.

10.1101/2023.01.04.522803 — bioinformatics — Posted on 2023-01-06

3523 ChemGAPP; A Package for Chemical Genomics Analysis and Phenotypic Profiling.

Doherty, H. M.; Kritikos, G.; Galardini, M.; Banzhaf, M.; Moradigaravand, D.

10.1101/2023.01.05.522861 — bioinformatics — Posted on 2023-01-06

3524 Radiopaque Implantable Biomaterials for Nerve Repair

Pawelec, K. M.; Hix, J. M. L.; Shapiro, E. M.

10.1101/2023.01.05.522860 — bioengineering — Posted on 2023-01-06

3525 3D co-culture of macrophages and fibroblasts in a sessile drop chip for unveiling the role of macrophages in skin wound-healing

Lyu, X.; Cui, F.; Zhou, H.; Cao, B.; Cai, M.; Yang, S.; Sun, B.; Li, G.

10.1101/2023.01.04.522690 — bioengineering — Posted on 2023-01-06

3526 Highly multiplexed ddPCR-amplicon sequencing reveals strong Plasmodium falciparum population structure and isolated populations amenable to local elimination efforts in Zanzibar

Holzschuh, A.; Lerch, A.; Gerlovina, I.; Fakih, B. S.; Al-Mafazy, A.-W.; Reaves, E. J.; Ali, A.; Abbas, F.; Ali, M. H.; Ali, M. A.; Hetzel, M. W.; Yukich, J. O.; Koepfli, C.

10.1101/2023.01.05.522832 — genomics — Posted on 2023-01-06

3527 Intermediate molecular phenotypes to identify genetic markers of anthracycline-induced cardiotoxicity risk

Gomez-Vecino, A.; Corchado-Cobos, R.; Blanco-Gomez, A.; Garcia-Sancha, N.; Castillo-Lluva, S.; Martin-Garcia, A.; Prieto, C.; Ruiz-Pinto, S.; Pita, G.; Velasco-Ruiz, A.; Patino-Alonso, C.; Galindo-Villardon, M. P.; Vera-Pedrosa, M. L.; Jalife, J.; Mao, J. H.; Macias de Plasencia, G.; Castellanos-Martin, A.; Saez-Freire, M. d. M.; Mendiburu-Elicabe, M.; Fraile-Martin, S.; Rodriguez-Teixeira, T.; Garcia-Macias, C.; Galvis-Jimenez, J. M.; Garcia-Sanchez, A.; Isidoro-Garcia, M.; Fuentes, M.; Garcia-Cenador, M. B.; Garcia-Criado, F. J.; Garcia-Hernandez, J. L.; Hernandez-Garcia, M. A.; Cruz-Hernand

10.1101/2023.01.05.522844 — genetics — Posted on 2023-01-06

3528 Efficient, robust, and versatile fluctuation data analysis using MLE MUtation Rate calculator (mlemur)

Lazowski, K.

10.1101/2023.01.05.522850 — genetics — Posted on 2023-01-06

3529 Synchronous effective population size changes and genetic stability of forest trees through glacial cycles

Milesi, P.; Kastally, C.; Dauphin, B.; Cervantes, S.; Bagnoli, F.; Budde, K. B.; Cavers, S.; Fady, B.; Faivre-Rampant, P.; Gonzalez-Martinez, S. C.; Grivet, D.; Gugerli, F.; Jorge, V.; Lesur Kupin, I.; Ojeda, D. I.; Olsson, S.; Opgenoorth, L.; Pinosio, S.; Plomion, C.; Rellstab, C.; Rogier, O.; Scalabrin, S.; Scotti, I.; Vendramin, G. G.; Westergren, M.; GenTree Consortium, ; Lascoux, M.; Pyhajarvi, T.

10.1101/2023.01.05.522822 — evolutionary biology — Posted on 2023-01-06

3530 Comment on 'Connexins evolved after early chordates lost innexin diversity'

Kelmanson, I. V.; Bakin, E. A.; Karbat, I.; Slivko-Koltchik, G. A.; Reuveny, E.; Panchin, Y. V.

10.1101/2023.01.05.522624 — evolutionary biology — Posted on 2023-01-06

3531 CartoCell, a high-throughput pipeline for accurate 3D image analysis, unveils cell morphology patterns in epithelial cysts.

Andres-San Roman, J. A.; Gordillo-Vazquez, C.; Franco-Barranco, D.; Morato, L.; Tagua, A.; Vicente-Munuera, P.; Palacios, A. M.; Gavilan, M. P.; Annese, V.; Gomez-Galvez, P.; Arganda-Carreras, I.; Escudero, L. M.

10.1101/2023.01.05.522724 — developmental biology — Posted on 2023-01-06

3532 Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in normal and human mitochondrial disease models

Tian, D.; Cui, M.; Han, M.

10.1101/2023.01.05.522895 — cell biology — Posted on 2023-01-06

3533 High-throughput single molecule tracking identifies drug interactions and cellular mechanisms

10.1101/2023.01.05.522916 — cell biology — Posted on 2023-01-06

3534 HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

Azuma, K.; Sakamoto, M.; Katayama, S.; Matsui, A.; Nakamichi, K.; Goshima, N.; Watanabe, S.; Nakayama, J.; Semba, K.

10.1101/2021.05.16.444388 — cancer biology — Posted on 2023-01-06

3535 HPC-Atlas: Computationally Constructing A Comprehensive Atlas of Human Protein Complexes

Pan, Y.; Li, R.; Li, W.; Lv, L.; Guan, J.; Zhou, S.

10.1101/2023.01.03.522554 — bioinformatics — Posted on 2023-01-05

3536 A single cell transcriptomic and clonal analysis depict valvulogenesis

Fahrat, B.; Bordeu, I.; Jagla, B.; Blanc, H.; Loulier, K.; Simons, B. D.; Beaurepaire, E.; Livet, J.; Puceat, M.

10.1101/2022.08.06.503022 — developmental biology — Posted on 2023-01-06

3537 Adult neurogenesis improves spatial information encoding in the mouse hippocampus

Frechou, M. A.; Martin, S. S.; McDermott, K. D.; Gokhan, S.; Tome, W.; Coen-Cagli, R.; Goncalves, J. T.

10.1101/2022.11.30.518622 — neuroscience — Posted on 2023-01-05

3538 Unified Tumor Growth Mechanisms from Multimodel Inference and Dataset Integration

Beik, S. P.; Harris, L. A.; Kochen, M. A.; Sage, J.; Quaranta, V.; Lopez, C. F.

10.1101/2022.07.22.500696 — systems biology — Posted on 2023-01-05

3539 G-quadruplex landscape and its regulation revealed by a new antibody capture method

Datta, S.; Patel, M.; Sathyaseelan, C.; Ghosh, C.; Mudgal, A.; Patel, D.; Rathinavelan, T.; Singh, U.

10.1101/2022.09.03.506459 — genomics — Posted on 2023-01-05

3540 Vast heterogeneity in cytoplasmic diffusion rates revealed by nanorheology and Doppelgänger simulations

Garner, R. M.; Molines, A. T.; Theriot, J. A.; Chang, F.

10.1101/2022.05.11.491518 — cell biology — Posted on 2023-01-05

3541 The nonlinearity of regulation in biological networks

Manicka, S.; Johnson, K.; Levin, M.; Murrugarra, D.

10.1101/2021.12.22.473903 — systems biology — Posted on 2023-01-05

3542 Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

Vijjamarri, A. K.; Niu, X.; Vandermeulen, M. D.; Onu, C.; Zhang, F.; Qiu, H.; Gupta, N.; Gaikwad, S.; Greenberg, M.; Cullen, P.; Lin, Z.; Hinnebusch, A. G.

10.1101/2023.01.05.522830 — molecular biology — Posted on 2023-01-05

3543 Competition co-immunoprecipitation reveals interactors of the chloroplast CPN60 chaperonin machinery

Ries, F.; Weil, H. L.; Herkt, C.; Muehlhaus, T.; Sommer, F.; Schroda, M.; Willmund, F.

10.1101/2023.01.05.522938 — molecular biology — Posted on 2023-01-05

3544 The metabolic enzyme EXT1 is sufficient to induce the epithelial-mesenchymal transition program in cancers

Solaimuthu, B.; Khatib, A.; Hayashi, A.; Tanna, M.; Lichtenstein, M.; Karmi, A.; Shaul, Y. D.

10.1101/2023.01.05.522866 — cancer biology — Posted on 2023-01-05

3545 The "replacing surgery" of cpDNA: de novo chemical synthesis and in vivo functional testing of Chlamydomonas chloroplast genome

Guo, C.; Zhang, G.; Wang, H.; Mei, R.; Li, X.; Li, H.; Jia, B.; Wang, C.; Hu, Z.

10.1101/2023.01.05.522807 — molecular biology — Posted on 2023-01-05

3546 Label-free high-resolution infrared spectroscopy for spatiotemporal analysis of complex living systems

Gvazava, N.; Konings, S.; Cepeda-Prado, E.; Skoryk, V.; Umeano, C. H.; Dong, J.; Silva, I. A. N.; Rylander Ottosson, D.; Leigh, N. D.; Wagner, D. E.; Klementieva, O.

10.1101/2023.01.05.522847 — molecular biology — Posted on 2023-01-05

3547 A novel, lightweight drive implant for chronic tetrode recordings in juvenile mice

Pendry, R. J.; Quigley, L. D.; Volk, L. J.; Pfeiffer, B. E.

10.1101/2023.01.04.522760 — neuroscience — Posted on 2023-01-05

3548 Different methods to estimate the phase of neural rhythms agree, but only during times of low uncertainty

Wodeyar, A.; Marshall, F. A.; Chu, C. J.; Eden, U. T.; Kramer, M. A.

10.1101/2023.01.05.522914 — neuroscience — Posted on 2023-01-05

3549 Functional connectivity favors hyperactivity leading to synapse loss in amyloidosis

L'esperance, O. J.; McGhee, J.; Davidson, G.; Smith, A. S.; Subramanian, J.

10.1101/2023.01.05.522900 — neuroscience — Posted on 2023-01-05

3550 DNA supercoiling-induced shapes alter minicircle hydrodynamic properties

Waszkiewicz, R.; Ranasinghe, M.; Fogg, J. M.; Catanese, D. J.; Ekiel-Jezewska, M. L.; Lisicki, M.; Demeler, B.; Zechiedrich, L.; Szymczak, P.

10.1101/2023.01.04.522747 — biophysics — Posted on 2023-01-05

3551 CRISPR-Cas-Docker: Web-based in silico docking and machine learning-based classification of crRNAs with Cas proteins

Park, H.-m.; Won, J.; Park, Y.; Anzaku, E. T.; Vankerschaver, J.; Van Messem, A.; De Neve, W.; Shim, H.

10.1101/2023.01.04.522819 — bioinformatics — Posted on 2023-01-05

3552 Evaluating Evasion Strategies in Zebrafish Larvae

Jiao, Y.; Colvert, B.; Man, Y.; McHenry, M. J.; Kanso, E.

10.1101/2023.01.05.522537 — animal behavior and cognition — Posted on 2023-01-05

3553 Testing the ion-current model for flagellar length sensing and IFT regulation

Ishikawa, H.; Moore, J.; Diener, D.; Delling, M.; Marshall, W. F.

10.1101/2022.08.20.504661 — cell biology — Posted on 2023-01-05

3554 Three bacterial DedA subfamilies with distinct functions and phylogenetic distribution

Todor, H.; Herrera, N.; Gross, C. A.

10.1101/2023.01.04.522824 — molecular biology — Posted on 2023-01-05

3555 Highly pathogenic avian influenza A H5 virus outbreaks in broiler farms in the Netherlands. Clinical signs, transmission and identification of reporting thresholds.

Gonzales, J. L.; Hobbelen, P. H.; van der Spek, A. N.; Vries, E. P.; Elbers, A. R.

10.1101/2023.01.05.522008 — microbiology — Posted on 2023-01-05

3556 Candidatus Nealsonbacteria (OD1) are biomass recycling ectosymbionts of methanogenic archaea in a stable benzene-degrading enrichment culture

Chen, X.; Molenda, O.; Brown, C. T.; Toth, C. R. A.; Guo, S.; Luo, F.; Howe, J.; Nesbo, C. L.; He, C.; Montabana, E. A.; Cate, J. H. D.; Banfield, J. F.; Edwards, E. A.

10.1101/2022.04.20.488981 — microbiology — Posted on 2023-01-05

3557 ATP is a major determinant of phototrophic bacterial longevity in growth arrest.

Yin, L.; Ma, H.; Fones, E. M.; Morris, D.; Harwood, C. S.

10.1101/2023.01.04.522825 — microbiology — Posted on 2023-01-05

3558 Home-field advantage affects the local adaptive interaction between Andropogon gerardii ecotypes and rhizobiome

Kazarina, A.; Sarkar, S.; Thapa, S.; Heeren, L.; Kamke, A.; Ward, K.; Hartung, E.; Ran, Q.; Galliart, M.; Jumpponen, A.; Johnson, L.; Lee, S. T. M.

10.1101/2023.01.04.522809 — microbiology — Posted on 2023-01-05

3559 Global gene expression of human malaria parasite liver stages throughout intrahepatocytic development

Zanghi, G.; Patel, H.; Camargo, N.; Smith, J. L.; Bae, Y.; Flannery, E. L.; Chuenchob, V.; Fishbaugher, M. E.; Mikolajczak, S. A.; Roobsoong, W.; Sattabongkot, J.; Hayes, K.; Vaughan, A. M.; Kappe, S. H. I.

10.1101/2023.01.05.522945 — microbiology — Posted on 2023-01-05

3560 Corynebacterium of the diphtheriae complex in companion animals: clinical and microbiological characterization of 64 cases from France

Museux, K.; Arcari, G.; Rodrigo, G.; Hennart, M.; Badell-Ocando, E.; Toubiana, J.; Brisse, S.

10.1101/2023.01.04.522820 — microbiology — Posted on 2023-01-05

3561 Analogue signaling of somato-dendritic synaptic activity to axon enhances GABA release in young cerebellar molecular layer interneurons

Trigo, F. F.; Kawaguchi, S.-y.

10.1101/2022.10.18.512768 — neuroscience — Posted on 2023-01-05

3562 Drosophila integrates visual evidence and counterevidence in self motion estimation

Tanaka, R.; Zhou, B.; Agrochao, M.; Badwan, B. A.; Au, B.; Matos, N. C. B.; Clark, D. A.

10.1101/2023.01.04.522814 — neuroscience — Posted on 2023-01-05

3563 Distinct prefrontal projections conversely orchestrate social competition and hierarchy

Choi, T.-Y.; Jeon, H.; Jeong, S.; Kim, E. J.; Kim, J.; Jeong, Y. H.; Kang, B.; Choi, M.; Koo, J. W.

10.1101/2023.01.04.522808 — neuroscience — Posted on 2023-01-05

3564 Ythdf2 ablation protects aged retina from RGC dendrite shrinking and visual decline

Niu, F.; Long, G.; Zhang, J.; She, Y.; Yu, J.; Ji, S.-J.

10.1101/2023.01.05.522855 — neuroscience — Posted on 2023-01-05

3565 Neurovascular reactivity increases across development in the visual and frontal pole networks as revealed by a breath-holding task: a longitudinal fMRI study

Chen, D. Y.; Di, X.; Biswal, B.

10.1101/2023.01.05.522905 — neuroscience — Posted on 2023-01-05

3566 Neurophysiological Changes Associated with Vibroacoustically-augmented Breath-focused Mindfulness for Dissociation: Targeting Interoception and Attention

Fani, N.; Guelfo, A.; La Barrie, D.; Teer, A. P.; Clendinen, C.; Karimzadeh, L.; Jain, J.; Ely, T. D.; Powers, A.; Kaslow, N. J.; Bradley, B.; Siegle, G. J.

10.1101/2023.01.04.521609 — neuroscience — Posted on 2023-01-05

3567 Chronic Changes In Oligodendrocyte Sub-Populations After Middle Cerebral Artery Occlusion in Neonatal Mice.

Frazier, A. P.; Mitchell, D. N.; Given, K. S.; Burch, A. M.; Childs, C. R.; Moreno-Garcia, M.; Corigliano, M. R.; Quillinan, N.; Macklin, W. B.; Herson, P.; Dingman, A.

10.1101/2023.01.05.522879 — neuroscience — Posted on 2023-01-05

3568 Prenatal benzene exposure alters offspring hypothalamic development predisposing to metabolic disease in later life

Koshko, L.; Scofield, S.; Debarba, L.; Stilgenbauer, L.; Sacla, M.; Fakhoury, P.; Jayarathne, H.; Perez-Mojica, J. E.; Griggs, E.; Lempradl, A.; Sadagurski, M.

10.1101/2023.01.05.522910 — neuroscience — Posted on 2023-01-05

3569 Dihydroxy-Metabolites of Dihomo-gamma-linolenic Acid Drive Ferroptosis- Mediated Neurodegeneration

Sarparast, M.; Pourmand, E.; Hinman, J.; Vonarx, D.; Reason, T.; Zhang, F.; Paithankar, S.; Chen, B.; Borhan, B.; Watts, J. L.; Alan, J.; Lee, K. S. S.

10.1101/2023.01.05.522933 — neuroscience — Posted on 2023-01-05

3570 BundleWarp, streamline-based nonlinear registration of white matter tracts

Chandio, B. Q.; Olivetti, E.; Romero, D.; Harezlak, J.; Garyfallidis, E.

10.1101/2023.01.04.522802 — neuroscience — Posted on 2023-01-05

3571 Impaired migration and premature differentiation underlie the neurological phenotype associated with PCDH12 loss of function

Rakotomamonjy, J.; Rylaarsdam, L.; Fares-Taie, L.; McDermott, S.; Davies, D.; Yang, G.; Fagbemi, F.; Epstein, M.; Guemez-Gamboa, A.

10.1101/2023.01.05.522934 — neuroscience — Posted on 2023-01-05

3572 Emergence of brain-like mirror-symmetric viewpoint tuning in convolutional neural networks

Farzmahdi, A.; Zarco, W.; Freiwald, W.; Kriegeskorte, N.; Golan, T.

10.1101/2023.01.05.522909 — neuroscience — Posted on 2023-01-05

3573 Loss of secondary motor cortex neurons in chronic neuropathic pain

Das Gupta, A.; Zheng, H.; Asan, L.; John, J.; Kaushalya, S.; Beretta, C.; Kuner, R.; Knabbe, J.; Kuner, T.

10.1101/2023.01.05.522932 — neuroscience — Posted on 2023-01-05

3574 Placing approach-avoidance conflict within the framework of multi-objective reinforcement learning

Enkhtaivan, E.; Nishimura, J.; Cochran, A. L.

10.1101/2023.01.05.522878 — neuroscience — Posted on 2023-01-05

3575 The Preprint Club - A cross-institutional, community-based approach to peer reviewing

Richter, F. C.; Gea-Mallorqui, E.; Ruffin, N.; Vabret, N.

10.1101/2023.01.04.522570 — scientific communication and education — Posted on 2023-01-05

3576 The metagenomic analysis of viral diversity in Colorado potato beetle public NGS data

Starchevskaya, M.; Kamanova, E.; Vyatkin, Y.; Tregubchak, T.; Bauer, T.; Bodnev, S.; Rotskaya, U.; Polenogova, O.; Kryukov, V.; Antonets, D.

10.1101/2023.01.04.522816 — bioinformatics — Posted on 2023-01-05

3577 Impact of phylogeny on structural contact inference from protein sequence data

Dietler, N.; Lupo, U.; Bitbol, A.-F.

10.1101/2022.09.26.509588 — bioinformatics — Posted on 2023-01-05

3578 Refined novel techniques for long term cryo-storage using vitrification and laser warming

Lin, C.; Hsieh, W.-C.; Loeslakwiboon, K.; Huang, C.-L.; Chen, T.-C.; Tsai, S.

10.1101/2023.01.04.521297 — bioengineering — Posted on 2023-01-05

3579 Microbial siderophore production is tightly coupled to iron in hydrothermal plumes

Hoffman, C. L.; Monreal, P. J.; Albers, J. B.; Lough, A. J. M.; Santoro, A. E.; Mellett, T.; Buck, K. N.; Tagliabue, A.; Lohan, M. C.; Resing, J. A.; Bundy, R. M.

10.1101/2023.01.05.522639 — biochemistry — Posted on 2023-01-05

3580 Compulsivity is linked to maladaptive choice variability but unaltered reinforcement learning under uncertainty

Lee, J. K.; Rouault, M.; Wyart, V.

10.1101/2023.01.05.522867 — animal behavior and cognition — Posted on 2023-01-05

3581 Bouts of rest and physical activity in C57BL/6J mice

Pernold, K.; Rullman, E.; Ulfhake, B.

10.1101/2023.01.05.522835 — animal behavior and cognition — Posted on 2023-01-05

3582 The metacognitive control of decisions predicts whether and how mice override their default policy

Schreiweis, C.; Euvrard, M.; Burguiere, E.; Daunizeau, J.

10.1101/2023.01.04.522806 — animal behavior and cognition — Posted on 2023-01-05

3583 Fake IDs? Widespread misannotation of DNA Transposons as a General Transcription Factor

Hassan, N. T.; Adelson, D. L.

10.1101/2022.11.24.517799 — genomics — Posted on 2023-01-05

3584 A genomic test of subspecies in the Eunota togata species group (Coleoptera: Cicindelidae): Morphology masks evolutionary relationships and taxonomy

Laroche, R. A. S.; Duran, D. P.; Lee, C.-T. A.; Godwin, W.; Roman, S. J.; Herrmann, D. P.; Egan, S. P.

10.1101/2023.01.05.522877 — evolutionary biology — Posted on 2023-01-05

3585 Temperature and nutrients drive eco-phenotypic dynamics in a microbial food web

Han, Z.-Y.; Wieczynski, D. J.; Yammine, A.; Gibert, J. P.

10.1101/2021.08.12.456102 — ecology — Posted on 2023-01-05

3586 A glia cell dependent mechanism at a peripheral nerve plexus critical for target-selective axon regeneration

Walker, L. J.; Guevara, C.; Kawakami, K.; Granato, M.

10.1101/2023.01.05.522786 — neuroscience — Posted on 2023-01-05

3587 Chronic seizure-induced serotonin pathway dysregulation coincides with mortality in Alzheimer s disease mouse models

DEL POZO, A.; KNOX, K. M.; LEHMANN, L.; DAVIDSON, S.; JAYADEV, S.; BARKER-HALISKI, M.

10.1101/2023.01.05.522897 — neuroscience — Posted on 2023-01-05

3588 A Convolutional Autoencoder-based Explainable Clustering Approach for Resting-State EEG Analysis

Ellis, C. A.; Miller, R.; Calhoun, V.

10.1101/2023.01.04.522805 — neuroscience — Posted on 2023-01-05

3589 Maternal diesel exposure and maternal choline supplementation interactions in fetal and placental immune factors

Maurer, S. V.; Bolton, J. L.; Bilbo, S. D.; Williams, C. L.

10.1101/2023.01.04.522511 — neuroscience — Posted on 2023-01-05

3590 Low dimensional criticality embedded in high dimensional awake brain dynamics

Fontenele, A. J.; Sooter, J. S.; Norman, V. K.; Gautam, S. H.; Shew, W.

10.1101/2023.01.05.522896 — neuroscience — Posted on 2023-01-05

3591 Critical assessment of E. coli genome-scale metabolic model with high-throughput mutant fitness data

Bernstein, D. B.; Akkas, B.; Price, M. N.; Arkin, A. P.

10.1101/2023.01.05.522875 — systems biology — Posted on 2023-01-05

3592 Cell-free expression and characterization of multivalent rhamnose-binding lectins using biolayer interferometry

Warfel, K. F.; Laigre, E.; Sobol, S. E.; Gillon, E.; VARROT, A.; Renaudet, O.; Dejeu, J.; Jewett, M.; Imberty, A.

10.1101/2023.01.05.522863 — synthetic biology — Posted on 2023-01-05

3593 Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice

Macip, C. C.; Hasan, R.; Hoznek, V.; Kim, J.; Metzger, L. E.; Sethna, S.; Davidsohn, N.

10.1101/2023.01.04.522507 — bioengineering — Posted on 2023-01-05

3594 The Effects of Histone H2B ubiquitylations and H3K79me3 on Transcription Elongation

Huynh, M. T.; Sengupta, B.; Krajewski, W. A.; Lee, T.-H.

10.1101/2023.01.05.522859 — biochemistry — Posted on 2023-01-05

3595 Dispersal overwhelms variation in host quality to shape nectar microbiome assembly.

Francis, J. S.; Mueller, T. G.; Vannette, R. L.

10.1101/2023.01.05.522929 — ecology — Posted on 2023-01-05

3596 INO80 regulates chromatin accessibility to facilitate meiotic sex chromosome inactivation

Chakraborty, P.; Magnuson, T.

10.1101/2023.01.04.522761 — developmental biology — Posted on 2023-01-05

3597 Modulation of protein-DNA binding reveals mechanisms of spatiotemporal gene control in early Drosophila embryos

Syed, S.; Duan, Y.; Lim, B.

10.1101/2023.01.05.522923 — developmental biology — Posted on 2023-01-05

3598 Proteomic analysis of flagella from Chlamydomonas mutants lacking the central pair apparatus reveals loss of radial spoke head proteins

Wemmer, K. A.; AZIMZADEH, J. F.; Marshall, W. F.

10.1101/2022.10.02.510551 — cell biology — Posted on 2023-01-05

3599 Cas phosphorylation regulates focal adhesion assembly

Kumar, S.; Stainer, A.; Dubrulle, J.; Simpkins, C.; Cooper, J.

10.1101/2022.12.19.521109 — cell biology — Posted on 2023-01-05

3600 SCAR and the Arp2/3 complex polarise the actomyosin cortex and plasma membrane organization in asymmetrically dividing neuroblasts

Cazzagon, G.; Roubinet, C.; Baum, B.

10.1101/2023.01.05.522888 — cell biology — Posted on 2023-01-05

3601 Type I IFN stimulates lymph node stromal cells from adult and old mice during a West Nile virus infection

Bennett, A. K.; Richner, M.; Mun, M. D.; Richner, J. M.

10.1101/2023.01.05.522898 — immunology — Posted on 2023-01-05

3602 Memory out of context: Spacing effects and decontextualization in a computational model of the medial temporal lobe

Antony, J. W.; Liu, X. L.; Zheng, Y. W.; Ranganath, C.; O'Reilly, R. C.

10.1101/2022.12.01.518703 — neuroscience — Posted on 2023-01-05

3603 Point mutations in the catalytic domain disrupt cellulose synthase (CESA6) vesicle trafficking and protein dynamics

Huang, L.; Zhang, W.; Li, X.; Staiger, C. J.; Zhang, C.

10.1101/2022.04.04.487015 — plant biology — Posted on 2023-01-05

3604 Generation of eco-friendly channel catfish, Ictalurus punctatus, harboring alligator cathelicidin gene with robust disease resistance by harnessing different CRISPR/Cas9-mediated systems

Wang, J.; Su, B.

10.1101/2023.01.05.522889 — bioengineering — Posted on 2023-01-05

3605 The complex inhibitory mechanism of glycomimetics with human heparanase

Whitefield, C.; Vo, Y.; Schwartz, B. D.; Hepburn, C.; Ahmed, F. H.; Onagi, H.; Banwell, M. G.; Nelms, K.; Malins, L. R.; Jackson, C. J.

10.1101/2023.01.05.522817 — biochemistry — Posted on 2023-01-05

3606 SPRUCE: Single-cell Pairwise Relationships Untangled by Composite Embedding model

Subedi, S.; Park, Y.

10.1101/2022.09.16.508327 — bioinformatics — Posted on 2023-01-05

3607 Rac negative feedback links local PIP3 rate-of-change to dynamic control of neutrophil guidance

Town, J. P.; Weiner, O. D.

10.1101/2022.12.30.521706 — cell biology — Posted on 2023-01-05

3608 Simultaneous Inhibition of the Arp2/3 Complex and Formins Enhances de novo Actin Filament Nucleation in Arabidopsis thaliana

Xu, L.; Cao, L.; Li, J.; Staiger, C. J.

10.1101/2022.08.03.502536 — cell biology — Posted on 2023-01-05

3609 Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion

Yue, C.; Song, W.; Wang, L.; Jian, F.; Chen, X.; Gao, F.; Shen, Z.; Wang, Y.; Wang, X.; Cao, Y. R.

10.1101/2023.01.03.522427 — immunology — Posted on 2023-01-05

3610 Dissecting the Thermodynamics of ATP Binding to GroEL One Nucleotide at a Time

Walker, T.; Sun, H. M.; Gunnels, T.; Wysocki, V.; Laganowsky, A.; Rye, H.; Russell, D. H.

10.1101/2022.09.13.507831 — biophysics — Posted on 2023-01-05

3611 MARSY: A multitask deep learning framework for prediction of drug combination synergy scores

El Khili, M. R.; Memon, S. A.; Emad, A.

10.1101/2022.06.07.495155 — bioinformatics — Posted on 2023-01-05

3612 The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

Cao, X.; Nguyen, V.; Tsai, J.; Gao, C.; Tian, Y.; Zhang, Y.; Carver, W.; Kiaris, H.; Cui, T.; Tan, W.

10.1101/2023.01.05.522853 — microbiology — Posted on 2023-01-05

3613 Poor neutralizing antibody responses against SARS-CoV-2 Omicron BQ.1.1 and XBB in Norway in October 2022

Vikse, E. L.; Fossum, E.; Erdal, M. S.; Hungnes, O.; Bragstad, K.

10.1101/2023.01.05.522845 — immunology — Posted on 2023-01-05

3614 Targets and cross-reactivity of human T cell recognition of Common Cold Coronaviruses

Tarke, A.; Zhang, Y.; Methot, N.; Narowski, T. N.; Phillips, E.; Mallal, S.; Frazier, A.; Filaci, G.; Weiskopf, D.; Dan, J. M.; Lakshmanane, P.; Scheuermann, R. H.; Sette, A.; Grifoni, A.

10.1101/2023.01.04.522794 — immunology — Posted on 2023-01-05

3615 The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus

10.1101/2021.08.18.456792 — immunology — Posted on 2023-01-05

3616 Reach corrections toward moving objects are faster than reach corrections toward jumping targets

Reschechtko, S.; Gnanaseelan, C.; Pruszynski, J. A.

10.1101/2022.12.24.521682 — neuroscience — Posted on 2023-01-05

3617 Development and validation of a type 2 diabetes machine learning classification model for EHR-based diagnostics and clinical decision support

Glanz, V.; Dudenkov, V.; Velikorodny, A.

10.1101/2022.10.08.511400 — bioinformatics — Posted on 2023-01-05

3618 Urban birds become less fearful following COVID-19 reopenings

Diamant, E.; MacGregor-Fors, I.; Blumstein, D. T.; Yeh, P. J.

10.1101/2023.01.04.522762 — animal behavior and cognition — Posted on 2023-01-05

3619 networkGWAS:A network-based approach to discover genetic associations

Muzio, G.; O'Bray, L.; Meng-Papaxanthos, L.; Klatt, J.; Borgwardt, K.

10.1101/2021.11.11.468206 — genomics — Posted on 2023-01-05

3620 CRTC-1 Balances Histone Trimethylation and Acetylation to Promote Longevity

Silva-Garcia, C. G.; Lascarez-Lagunas, L. I.; Papsdorf, K.; Heintz, C.; Prabhakar, A.; Morrow, C. S.; Pajuelo, L.; Sharma, A.; Liu, J.; Colaiacovo, M. P.; Brunet, A.; Mair, W. B.

10.1101/2022.08.31.506037 — genetics — Posted on 2023-01-05

3621 Cellular and Circuit Organization of the Locus Coeruleus of Adult Mice

McKinney, A.; Hu, M.; Jing, J.; Hoskins, A.; Mohammadyar, A.; Naeem, N.; Patel, S.; Sheth, B. R.; Jiang, X.

10.1101/2022.03.01.481656 — neuroscience — Posted on 2023-01-05

3622 Vitamin D inhibits osteosarcoma by reprogramming nonsense-mediated RNA decay and SNAI2-mediated epithelial-to-mesenchymal transition

Capobianco, E.; McGaughey, V.; Seraphin, G.; Heckel, J.; Rieger, S.; Lisse, T. S.

10.1101/2023.01.04.522778 — cancer biology — Posted on 2023-01-05

3623 Collective Evolution Learning Model for Vision-Based Collective Motion with Collision Avoidance

Krongauz, D. L.; Lazebnik, T.

10.1101/2022.06.09.495429 — bioinformatics — Posted on 2023-01-05

3624 CUT&Tag recovers up to half of ENCODE ChIP-seq peaks in modifications of H3K27

Hu, D.; Abbasova, L.; Schilder, B. M.; Nott, A.; Skene, N. G.; Marzi, S. J.

10.1101/2022.03.30.486382 — genomics — Posted on 2023-01-05

3625 Direct digital sensing of protein biomarkers in solution

Krainer, G.; Saar, K. L.; Arter, W. E.; Welsh, T. J.; Czekalska, M. A.; Jacquat, R. P. B.; Peter, Q.; Traberg-Christensen, W.; Pujari, A.; Jayaram, A. K.; Challa, P.; Taylor, C. G.; van der Linden, L.-M.; Franzmann, T.; Owens, R. M.; Alberti, S.; Klenerman, D.; Knowles, T. P. J.

10.1101/2020.05.24.113498 — biophysics — Posted on 2023-01-05

3626 ATP diffusional gradients are sufficient to maintain bioenergetic homeostasis in synaptic boutons lacking mitochondria

Kuznetsov, I. A.; Kuznetsov, A. V.

10.1101/2022.12.09.519840 — biophysics — Posted on 2023-01-05

3627 Image-centric compression of protein structures improves space savings

Staniscia, L.; Yu, Y. W.

10.1101/2022.01.20.477098 — bioinformatics — Posted on 2023-01-05

3628 Resurrection of human endogenous retroviruses during aging reinforces senescence

Liu, X.; Liu, Z.; Wu, Z.; Ren, J.; Fan, Y.; Sun, L.; Cao, G.; Niu, Y.; Zhang, B.; Ji, Q.; Jiang, X.; Wang, C.; Wang, Q.; Ji, Z.; Li, L.; Esteban, C. R.; Yan, K.; Li, W.; Cai, Y.; Wang, S.; Zheng, A.; Zhang, Y.; Tan, S.; Cai, Y.; Song, M.; Lu, F.; Tang, F.; Ji, W.; Zhou, Q.; Belmonte, J. C. I.; Zhang, W.; Qu, J.; Liu, G.

10.1101/2021.02.22.432260 — cell biology — Posted on 2023-01-05

3629 Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes

Fialkoff, G.; Takahashi, N.; Sharkia, I.; Gutin, J.; Pongor, L.; Rajan, A.; Nichols, S.; Sciuto, L.; Vilimas, R.; Graham, C.; Desai, P.; Maoz, M.; Rottenberg, Y.; Shoshan, N.; Nechushtan, H.; Peretz, T.; Roame, D.; Carter, P.; Kumar, R.; Hubert, A.; Cohen, J. E.; Upadhyay, D.; Salah, A.; Temper, M.; Grinshpun, A.; Figg, W. D.; Zick, A.; Sadeh, R.; Friedman, N.; Thomas, A.

10.1101/2022.06.24.497386 — cancer biology — Posted on 2023-01-05

3630 Single-cell atlases of two lophotrochozoan larvae highlight their complex evolutionary histories

Piovani, L.; Leite, D. J.; Yanez-Guerra, L. A.; Simpson, F.; Musser, J. M.; Salvador-Martinez, I.; Marletaz, F.; Jekely, G.; Telford, M. J.

10.1101/2023.01.04.522730 — evolutionary biology — Posted on 2023-01-05

3631 Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST

Long, Y.; Ang, K. S.; Li, M.; Chong, K. L. K.; Sethi, R.; Zhong, C.; Xu, H.; Ong, Z.; Sachaphibulkij, K.; Chen, A.; Li, Z.; Fu, H.; Wu, M.; Lim, H. K. L.; Liu, L.; Chen, J.

10.1101/2022.08.02.502407 — bioinformatics — Posted on 2023-01-05

3632 A phosphorylation switch regulates RAB6 function during mitosis

Jimenez, A. J.; Bousquet, H.; Bardin, S.; Perez, F.; Goud, B.; Miserey, S.

10.1101/2023.01.05.522745 — cell biology — Posted on 2023-01-05

3633 Process Optimization of Plasma Bubbling Set Up for Cow Milk Decontamination and Quality Evaluation.

Dash, S.; Jaganmohan, R.

10.1101/2022.12.28.522063 — microbiology — Posted on 2023-01-05

3634 The neuron mixer and its impact on human brain dynamics

Luff, C.; Peach, R. L.; Mallas, E.-J.; Rhodes, E.; Laumann, F.; Boyden, E. S.; Sharp, D. J.; Barahona, M.; Grossman, N.

10.1101/2023.01.05.522833 — neuroscience — Posted on 2023-01-05

3635 Adapting fundamental concepts from insect societies to the demands of bio-ontologies.

Silva, T. S. R.; Pie, M. R.

10.1101/2021.05.18.444717 — zoology — Posted on 2023-01-05

3636 Neural correlates of probabilistic information processing in gesture-speech integration

Zhao, W.; Li, X.; Du, Y.

10.1101/2022.11.23.517759 — neuroscience — Posted on 2023-01-05

3637 Unravelling microalgal-bacterial interactions in aquatic ecosystems through 16S rRNA gene-based co-occurrence networks

Pushpakumara, B. L. D. U.; Tandon, K.; Willis, A.; Verbruggen, H.

10.1101/2022.01.05.475147 — ecology — Posted on 2023-01-04

3638 Coordinated electrical and chemical signaling between two neurons orchestrates switching of motor states

Bach, M.; Bergs, A.; Mulcahy, B.; Zhen, M.; Gottschalk, A.

10.1101/2023.01.04.522780 — neuroscience — Posted on 2023-01-05

3639 Identification of basic helix-loop-helix transcription factors that activate betulinic acid biosynthesis by RNA-sequencing of hydroponically cultured Lotus japonicus

Suzuki, H.; Takahashi, H.; Fukushima, E. O.; Nakazono, M.; Muranaka, T.; Seki, H.

10.1101/2022.11.16.516519 — plant biology — Posted on 2023-01-04

3640 Single-cell atlases of two lophotrochozoan larvae highlight their complex evolutionary histories

Piovani, L.; Leite, D. J.; Yanez-Guerra, L. A.; Simpson, F.; Musser, J. M.; Salvador-Martinez, I. A.; Marletaz, F.; Jekely, G.; Telford, M. J.

10.1101/2023.01.04.522730 — evolutionary biology — Posted on 2023-01-04

3641 Gender impacts the relationship between mood disorder symptoms and effortful avoidance performance

Forys, B. J.; Tomm, R. J.; Stamboliyska, D.; Terpstra, A. R.; Clark, L.; Chakrabarty, T.; Floresco, S. B.; Todd, R. M.

10.1101/2022.06.21.497075 — neuroscience — Posted on 2023-01-04

3642 Conserved folding landscape of monomeric initiator caspases

Nag, M.; Clark, C.

10.1101/2023.01.04.522766 — biophysics — Posted on 2023-01-04

3643 Integrative proteogenomics using ProteomeGenerator2

Kwok, N.; Aretz, Z.; Takao, S.; Ser, Z.; Cifani, P.; Kentsis, A.

10.1101/2023.01.04.522774 — bioinformatics — Posted on 2023-01-04

3644 ElasticBLAST: Accelerating Sequence Search via Cloud Computing

Camacho, C.; Boratyn, G.; Joukov, V.; Vera Alvarez, R.; Madden, T. L.

10.1101/2023.01.04.522777 — bioinformatics — Posted on 2023-01-04

3645 A framework evaluating the utility of multi-gene, multi-disease population-based panel testing that accounts for uncertainty in penetrance estimates

Liang, J. W.; Christensen, K. D.; Green, R. C.; Kraft, P.

10.1101/2022.08.10.503415 — genetics — Posted on 2023-01-04

3646 Decoding the fundamental drivers of phylodynamic inference

Featherstone, L. A.; Duchene, S.; Vaughan, T. G.

10.1101/2022.06.07.495205 — evolutionary biology — Posted on 2023-01-04

3647 Nanopore-based enrichment of antimicrobial resistance genes -- a case study

Viehweger, A.; Marquet, M.; Hölzer, M.; Dietze, N.; Pletz, M.; Brandt, C.

10.1101/2021.08.29.458107 — microbiology — Posted on 2023-01-04

3648 Postsynaptic receptors regulate presynaptic neurotransmitter stability through trans-synaptic bridges

Godavarthi, S. K.; Hiramoto, M.; Ignatyev, Y.; Levin, J. B.; Li, H.; Pratelli, M.; Borchardt, J.; Czajkowski, C. M.; Borodinsky, L. N.; Sweeney, L.; Cline, H. T.; Spitzer, N. C.

10.1101/2022.09.10.507343 — neuroscience — Posted on 2023-01-04

3649 Direct Brain Recordings Suggest a Causal Subsequent-Memory Effect

Rubinstein, D. Y.; Weidemann, C. T.; Sperling, M. R.; Kahana, M. J.

10.1101/2022.10.12.511606 — neuroscience — Posted on 2023-01-04

3650 Music and Speech Elicit Similar Subcortical Responses in Human Listeners

Shan, T.; Cappelloni, M. S.; Maddox, R. K.

10.1101/2022.10.14.512309 — neuroscience — Posted on 2023-01-04

3651 Chondro/osteoclasts and mast cells are co-villains in the joint destruction of rheumatoid arthritis

McClure, J.; McClure, S. F.

10.1101/2023.01.04.522721 — pathology — Posted on 2023-01-04

3652 A multi-tissue single-cell tumor microenvironment atlas reveals myeloid-derived cell states with significant impact on clinical outcome

Maklouf, G. R.; Guimaraes, G. R.; Teixeira, C. E.; Pretti, M. A. M.; de Oliveira Santos, L.; Tessarollo, N. G.; Toledo, N. E.; Falchetti, M.; Dimas, M. M.; Serain, A. F.; Bastos, N. C.; de Macedo, F. C.; Rodrigues, F. R.; da Silva, J. L.; Lummertz-Rocha, E.; Chaves, C. B. P.; de Melo, A. C.; Moraes-Vieira, P. M. M.; Mori, M. A.; Boroni, M.

10.1101/2023.01.04.522727 — cancer biology — Posted on 2023-01-04

3653 Transcription Through Roadblock Systems Reveals a Hybrid Transit Mechanism

Qian, J.; Cartee, A. G.; Dunlap, D.; Artsimovitch, I.; Finzi, L.

10.1101/2023.01.04.522798 — biophysics — Posted on 2023-01-04

3654 MIDAS: a deep generative model for mosaic integration and knowledge transfer of single-cell multimodal data

He, Z.; Chen, Y.; Hu, S.; An, S.; Shi, J.; Liu, R.; Zhou, J.; Dong, G.; Shi, J.; Zhao, J.; Wang, J.; Zhu, Y.; Ou-Yang, L.; Bo, X.; Ying, X.

10.1101/2022.12.13.520262 — bioinformatics — Posted on 2023-01-04

3655 Resurrecting the Alternative Splicing Landscape of Archaic Hominins using Machine Learning

Brand, C. M.; Colbran, L. L.; Capra, J. A.

10.1101/2022.08.02.502533 — genomics — Posted on 2023-01-04

3656 Disruption of the standard kinetochore in holocentric Cuscuta species

Neumann, P.; Oliveira, L. C.; Jang, T.-S.; Novak, P.; Koblizkova, A.; Schubert, V.; Houben, A.; Macas, J.

10.1101/2023.01.04.522735 — genetics — Posted on 2023-01-04

3657 Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity in Drosophila

Hwangbo, D.-S.; Kwon, Y.-J.; Iwanaszko, M.; Jiang, P.; Abbasi, L.; Wright, N.; Alli, S.; Hutchison, A. L.; Dinner, A.; Braun, R.; Allada, R.

10.1101/2023.01.04.522718 — genetics — Posted on 2023-01-04

3658 A potential cost of evolving epibatidine resistance in poison frogs

York, J. M.; Borghese, C. M.; George, A. A.; Cannatella, D. C.; Zakon, H. H.

10.1101/2023.01.04.522789 — evolutionary biology — Posted on 2023-01-04

3659 Optimization of molecular methods for detection and quantification of specific duckweed-bacteria interactions

Acosta, K.; Sorrels, S.; Chrisler, W. B.; Huang, W.; Gilbert, S.; Brinkman, T.; Michael, T. P.; Lebeis, S.; Lam, E.

10.1101/2023.01.04.522651 — ecology — Posted on 2023-01-04

3660 Predation, community asynchrony, and metacommunity stability in cyanobacterial mats

Cissell, E. C.; McCoy, S. J.

10.1101/2022.10.07.511315 — ecology — Posted on 2023-01-04

3661 Transient loss of Polycomb components induces an epigenetic cancer fate

Parreno, V.; LOUBIERE, V.; Schuettengruber, B.; Erokhin, M.; Gyorrfy, B.; Di Stefano, M.; Fritsch, L.; Moreaux, J.; Chetverina, D.; Martinez, A.-M.; Cavalli, G.

10.1101/2023.01.04.522799 — developmental biology — Posted on 2023-01-04

3662 Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot process

Gerlach, G. F.; Imseis, Z. H.; Cooper, S. L.; Santos, A. N.; O'Brien, L. L.

10.1101/2022.11.03.515102 — developmental biology — Posted on 2023-01-04

3663 The LINC complex inhibits excessive chromatin repression

Amiad Pavlov, D.; Unnikannan, C.; Lorber, D.; Bajpai, G.; Olender, T.; Stoops, E.; Reuveny, A.; Safran, S.; Volk, T.

10.1101/2022.02.09.479725 — cell biology — Posted on 2023-01-04

3664 Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during Zebrafish Left-Right Organizer development

Aljiboury, A. A.; Ingram, E.; Krishnan, N.; Ononiwu, F.; Pal, D.; Manikas, J.; Taveras, C.; Hall, N. A.; Da Silva, J.; Freshour, J.; Hehnly, H.

10.1101/2022.10.31.514532 — cell biology — Posted on 2023-01-04

3665 Spatial molecular imaging of the human type 2 diabetic islet

Kolar, G. R.; Ross, D.; Killingbeck, E.; Samson, W. K.; Yosten, G. L. C.

10.1101/2023.01.04.519955 — molecular biology — Posted on 2023-01-04

3666 3D genome organization around nuclear speckles drives mRNA splicing efficiency

Bhat, P.; Chow, A.; Emert, B.; Ettlin, O.; Quinodoz, S. A.; Takei, Y.; Huang, W.; Blanco, M. R.; Guttman, M.

10.1101/2023.01.04.522632 — molecular biology — Posted on 2023-01-04

3667 Targeted insertion and reporter transgene activity at a gene safe harbor of the human blood fluke, Schistosoma mansoni

Tanno, W. I.; Moscheid, M. F.; Chaparro, C.; Mann, V. H.; Quack, T.; Rodpai, R.; Miller, A. N.; Wistiphongpun, P.; Buakaew, W.; Mentink-Kane, M.; Miller, L.; Schmid, S.; Popratiloff, A.; Grevelding, C.; Grunau, C.; Brindley, P. J.

10.1101/2022.09.02.506379 — molecular biology — Posted on 2023-01-04

3668 Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission

Sapiro, A. L.; Hayes, B. M.; Volk, R. F.; Zhang, J. Y.; Brooks, D. M.; Martyn, C.; Radkov, A.; Zhao, Z.; Kinnersley, M.; Secor, P. R.; Zaro, B. W.; Chou, S.

10.1101/2022.11.09.515847 — microbiology — Posted on 2023-01-04

3669 Microbial fingerprints reveal interaction between museum objects, curators and visitors

Simon, L.; Flocco, C.; Henke, D. M.; Rauer, L.; Müller, C.; Vogel, J.; Quassier, C.; Overmann, J.; Simon, S.

10.1101/2023.01.04.522779 — microbiology — Posted on 2023-01-04

3670 IL-15 enhances functional properties and responses of CD28-negative CD4+ cytotoxic T cells expanded in Systemic lupus erythematosus

Hong, X.; Ren, H.; Wang, T.; Wei, L.; Meng, S.; Song, W.; Chen, Y.; Li, H.; Zhao, Q.; Jiang, Z.; Liu, D.

10.1101/2023.01.04.522682 — immunology — Posted on 2023-01-04

3671 Hypo-responsiveness of human alveolar macrophages to IFN-γ is not due to attenuated STAT1 signaling

Thiel, B. A.; Lundberg, K. C.; Schlatzer, D.; Jarvela, J.; Li, Q.; Shaw, R.; Beckloff, S. E.; Chance, M. R.; Boom, W. H. A.; Silver, R. F.; Bebek, G.

10.1101/2022.12.07.519298 — immunology — Posted on 2023-01-04

3672 Epstein-Barr virus promotes T cell dysregulation in a humanized mouse model of multiple sclerosis

Allanach, J. R.; Fettig, N. M.; Hardman, B. K.; Fan, V.; Rosen, A. R.; Goldberg, E. J.; Morse, Z. J.; Shanina, I.; Vorobeychik, G.; Osborne, L. C.; Horwitz, M. S.

10.1101/2022.02.23.481716 — immunology — Posted on 2023-01-04

3673 Behavioral and Neuroanatomical Investigation of Attention Deficit Hyperactivity Disorder Pathogenesis in Juvenile Spontaneously Hypertensive Rats

Aydin, A. G.; Adiguzel, E.

10.1101/2023.01.04.522787 — neuroscience — Posted on 2023-01-04

3674 MNK1 and MNK2 expression in the human dorsal root and trigeminal ganglion

Shiers, S.; Sahn, J. J.; Price, T. J.

10.1101/2023.01.04.522773 — neuroscience — Posted on 2023-01-04

3675 Mechanisms of masking by Schroeder-phase harmonic tone complexes in the budgerigar (Melopsittacus undulatus)

Henry, K. S.; Wang, Y.; Abrams, K. S.; Carney, L. H.

10.1101/2022.10.26.513930 — neuroscience — Posted on 2023-01-04

3676 Systemic Calcitonin Gene-Related Peptide (CGRP) modifies auditory and vestibular endorgan electrical potentials, and increases auditory and vestibular hypersensitivities: Implications for vestibular migraine

Rahman, S. M.; Liang, B.; Faucher, S.; Fine, E.; Jonnala, R.; Holt, J. C.; Lee, C.; Luebke, A. E.

10.1101/2022.06.03.494764 — neuroscience — Posted on 2023-01-04

3677 Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonism Reduces Motion Sickness Indicators in Mouse Migraine Models

Rahman, S. M.; Luebke, A. E.

10.1101/2022.06.03.494762 — neuroscience — Posted on 2023-01-04

3678 Programmable Drug Control of Receptor Valency Modulates the Potency of Cell Therapeutics

Finn, P.; Chavez, M.; Chen, X.; Wang, H.; Rane, D. A.; Gurjar, J.; Qi, L. S.

10.1101/2023.01.04.522664 — synthetic biology — Posted on 2023-01-04

3679 Endophytic fungi related to the ash dieback causal agent encode signatures of pathogenicity on European ash

Rafiqi, M.; Kosawang, C.; Peers, J. A.; Jelonek, L.; Yvanne, H.; McMullan, M.; Nielsen, L. R.

10.1101/2023.01.04.522732 — plant biology — Posted on 2023-01-04

3680 The AFB1 auxin receptor controls the cytoplasmic auxin response pathway in Arabidopsis thaliana

Dubey, S. M.; Han, S.; Stutzman, N.; Prigge, M. J.; Medvecka, E.; Platre, M. P.; Busch, W.; Fendrych, M.; Estelle, M.

10.1101/2023.01.04.522696 — plant biology — Posted on 2023-01-04

3681 MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis

DeRollo, R. E.; Cazarin, J.; Ahmad Shahidan, S. N. A. B.; Burchett, J. B.; Mwangi, D.; Krishnaiah, S.; Hsieh, A. L.; Walton, Z. E.; Brooks, R.; Mello, S. S.; Weljie, A. M.; Dang, C. V.; Altman, B. J.

10.1101/2023.01.03.522637 — cancer biology — Posted on 2023-01-04

3682 Vitamin D inhibits osteosarcoma by reprogramming nonsense-mediated RNA decay and SNAI2-mediated epithelial-to-mesenchymal transition

Capobianco, E.; McGaughey, V.; Seraphin, G.; Heckel, J.; Rieger, S.; Lisse, T. S.

10.1101/2023.01.04.522778 — cancer biology — Posted on 2023-01-04

3683 A model for cis-regulation of transcriptional condensates and gene expression by proximal lncRNAs

Natarajan, P.; Shrinivas, K.; Chakraborty, A. K.

10.1101/2023.01.04.522753 — biophysics — Posted on 2023-01-04

3684 Multiphoton imaging of glucose, galactose, and fructose-induced formation of fluorescent advanced glycation end products in tissues

Lin, C.-J.; Mondal, S. I.; Lee, S.-L.; Kang, J.-W.; So, P. T.; Dong, C.-Y.

10.1101/2023.01.04.522782 — biophysics — Posted on 2023-01-04

3685 Patterning of membrane adhesion under hydraulic stress

Dinet, C.; Torres-Sanchez, A.; Arroyo, M.; Staykova, M.

10.1101/2023.01.04.522479 — biophysics — Posted on 2023-01-04

3686 Combined SPT and FCS methods highlight a mechanism of RNAP II oversampling in cell nuclei

FOURNIER, M.; LECLERC, P.; LERAY, A.; CHAMPELOVIER, D.; AGBAZAHOU, F.; BIDAUX, G.; FURLAN, A.; HELIOT, L.

10.1101/2022.07.27.501703 — biophysics — Posted on 2023-01-04

3687 Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors

Najma, B.; Baskaran, A.; Foster, P. J.; Duclos, G.

10.1101/2023.01.04.522797 — biophysics — Posted on 2023-01-04

3688 Dimensional Reduction for Single Molecule Imaging of DNA and Nucleosome Condensation by Polyamines, HP1α and Ki-67

Benning, N. A.; Kaestel-Hansen, J.; Rashid, F.; Park, S.; Urteaga, R. M.; Liao, T.-W.; Hao, J.; Berger, J. M.; Hatzakis, N. S.; Ha, T.

10.1101/2023.01.04.522433 — biophysics — Posted on 2023-01-04

3689 Unravelling cell type specific response to Parkinson's Disease at single cell resolution

Martirosyan, A.; Pestana, F.; Hebestreit, K.; Gasparyan, H.; Aleksanyan, R.; Poovathingal, S.; Marneffe, C.; Thal, D. R.; Kottick, A.; Hanson-Smith, V. J.; Guelfi, S.; Metzakopian, E.; Belgard, T. G.

10.1101/2023.01.04.522691 — bioinformatics — Posted on 2023-01-04

3690 Development and validation of a type 2 diabetes machine learning classification model for EHR-based diagnostics and clinical decision support

Glanz, V.; Dudenkov, V.; Velikorodny, A.

10.1101/2022.10.08.511400 — bioinformatics — Posted on 2023-01-04

3691 Generalized tree structure to annotate untargeted metabolomics and stable isotope tracing data

Li, S.; Zheng, S.

10.1101/2023.01.04.522722 — bioinformatics — Posted on 2023-01-04

3692 Sequence-to-sequence translation from mass spectra to peptides with a transformer model

Yilmaz, M.; Fondrie, W. E.; Bittremieux, W.; Nelson, R.; Ananth, V.; Oh, S.; Noble, W. S.

10.1101/2023.01.03.522621 — bioinformatics — Posted on 2023-01-04

3693 Organometallic Pillarplexes that bind DNA 4-way Holliday Junctions and Forks.

Craig, J. S.; Melidis, L.; Williams, H. D.; Dettmer, S. J.; Heidecker, A. A.; Altmann, P. J.; Guan, S.; Campbell, C.; Browning, D. F.; Sigel, R. K. O.; Johannsen, S.; Egan, R. T.; Aikman, B.; Casini, A.; Poethig, A.; Hannon, M. J.

10.1101/2023.01.04.522759 — biochemistry — Posted on 2023-01-04

3694 Potential of imputation for cost-efficient genomic selection for resistance to Flavobacterium columnare in rainbow trout (Oncorhynchus mykiss)

Fraslin, C.; Robledo, D.; Kause, A.; Houston, R. D.

10.1101/2023.01.04.522693 — genetics — Posted on 2023-01-04

3695 Indel driven rapid evolution of core nuclear pore protein gene promoters

Read, A. M.; McQuarrie, D. W. J.; Civetta, A.; Soller, M.

10.1101/2023.01.04.522740 — evolutionary biology — Posted on 2023-01-04

3696 Phylogenomics reveals patterns of ancient hybridization and differential diversification contributing to phylogenetic conflict in Populus L. and Salix L.

Sanderson, B. J.; Ghambir, D.; Feng, G.; Hu, N.; Cronk, Q. C.; Percy, D. M.; Freaner, F. M.; Johnson, M. G.; Smart, L. B.; Keefover-Ring, K.; Yin, T.; Ma, T.; DiFazio, S. P.; Liu, J.; Olson, M. S.

10.1101/2023.01.04.522772 — evolutionary biology — Posted on 2023-01-04

3697 Hybrid epigenomes reveal extensive local genetic changes to chromatin accessibility contribute to divergence in embryonic gene expression between species

Devens, H. R.; Davidson, P. L.; Byrne, M.; Wray, G. A.

10.1101/2023.01.04.522781 — evolutionary biology — Posted on 2023-01-04

3698 Simultaneous proteome localization and turnover analysis reveals spatiotemporal dynamics of unfolded protein responses

Currie, J.; Manda, V.; Hidalgo, V.; Ludwig, R. W.; Lam, M. P. Y.; Lau, E.

10.1101/2023.01.04.521821 — cell biology — Posted on 2023-01-04

3699 Calcium flux through ER-TGN contact sites facilitates cargo export

Ramazanov, B. R.; Di Martino, R.; Kumar, A.; Parchure, A.; Kim, Y.; Griesbeck, O.; Schwartz, M. A.; Luini, A.; von Blume, J.

10.1101/2022.12.19.521097 — cell biology — Posted on 2023-01-04

3700 MitoQuicLy: a high-throughput method for quantifying cell-free DNA from human plasma, serum, and saliva

Michelson, J.; Rausser, S.; Peng, A.; Yu, T.; Sturm, G.; Trumpff, C.; Kaufman, B. A.; Rai, A. J.; Picard, M.

10.1101/2023.01.04.522744 — molecular biology — Posted on 2023-01-04

3701 High Throughput Viability Assay for Microbiology

Meyer, C. T.; Lynch, G. K.; Stamo, D. F.; Miller, E. J.; Chatterjee, A.; Kralj, J. M.

10.1101/2023.01.04.522767 — microbiology — Posted on 2023-01-04

3702 Antibacterial activity of ethanolic and aqueous extracts of Zingiber officinale on Streptococcus pneumoniae and Pseudomonas aeruginosa

RUKUNDO, A.; OMARA, D.; MAJALIJA, S.; ODUR, S.; ALAFI, S.; OKECH, S. G.

10.1101/2023.01.03.522596 — microbiology — Posted on 2023-01-04

3703 An effective sanitizer for fresh produce production: In situ plasma activated water treatment inactivates pathogenic bacteria and maintains the quality of cucurbit fruit

Rothwell, J. G.; Hong, J.; Morrison, S. J.; Vyas, H. K. N.; Xia, B.; Mai-Prochnow, A.; McConchie, R.; Phan-Thien, K.-Y.; Cullen, P. J.; Carter, D. A.

10.1101/2023.01.03.522676 — microbiology — Posted on 2023-01-04

3704 Synthetic STING agonists elicit powerful vaccine adjuvancy providing robust central memory and anti-tumour effects

Towner, L. D.; Dahal, L. N.; Taylor, M. C.; Cox, K. L.; Inzhelevskaya, T.; Mack, M.; Wedge, S. R.; Richardson, C.; Cragg, M. S.; Beers, S. A.

10.1101/2023.01.04.522614 — immunology — Posted on 2023-01-04

3705 Label-free single-cell live imaging reveals fast metabolic switch in T lymphocytes

Paillon, N.; Ung, T. P. L.; Dogniaux, S.; Stringari, C.; Hivroz, C.

10.1101/2023.01.04.522685 — immunology — Posted on 2023-01-04

3706 Coordinated electrical and chemical signaling between two neurons orchestrates switching of motor states

Bach, M.; Bergs, A.; Mulcahy, B.; Zhen, M.; Gottschalk, A.

10.1101/2023.01.04.522780 — neuroscience — Posted on 2023-01-04

3707 Cold tolerance and diapause within across trophic levels: endoparasitic wasps and their fly host have similar phenotypes

McIntyre, T.; Andaloori, L.; Hood, G. R.; Feder, J. L.; Hahn, D. A.; Ragland, G. J.; Toxopeus, J.

10.1101/2023.01.04.522725 — physiology — Posted on 2023-01-04

3708 Machine Learning Reveals Lipidome Remodeling Dynamics in a Mouse Model of Ovarian Cancer

Bifarin, O. O.; Sah, S.; Gaul, D. A.; Moore, S. G.; Chen, R.; Palaniappan, M.; Kim, J.; Matzuk, M. M.; Fernandez, F. O.

10.1101/2023.01.04.520434 — cancer biology — Posted on 2023-01-04

3709 Wetting by biomolecular condensates increases membrane lipid packing and dehydration

Mangiarotti, A.; Siri, M.; Zhao, Z.; Malacrida, L.; Dimova, R.

10.1101/2023.01.04.522768 — biophysics — Posted on 2023-01-04

3710 The assembly landscape of the complete B-repeat superdomain from Staphylococcus epidermidis strain 1457

Yarawsky, A. E.; Herr, A. B.

10.1101/2023.01.04.522776 — biophysics — Posted on 2023-01-04

3711 Sequential unfolding mechanisms of monomeric caspases

Joglekar, I.; Clark, C.

10.1101/2023.01.04.522771 — biophysics — Posted on 2023-01-04

3712 How random is the review outcome? A systematic study of the impact of external factors on eLife peer review

Liang, W.; Mahowald, K.; Raymond, J.; Krishna, V.; Smith, D.; Jurafsky, D.; McFarland, D.; Zou, J.

10.1101/2023.01.04.522708 — bioinformatics — Posted on 2023-01-04

3713 Reconstruction of 3-dimensional tissue organization at the single-cell resolution

Fu, Y.; Das, A.; Wang, D.; Braun, R.; Yi, R.

10.1101/2023.01.04.522502 — bioinformatics — Posted on 2023-01-04

3714 MuLan-Methyl - Multiple Transformer-based Language Models for Accurate DNA Methylation Prediction

Zeng, W.; Gautam, A.; Huson, D. H.

10.1101/2023.01.04.522704 — bioinformatics — Posted on 2023-01-04

3715 Human Brain Endothelial Cell Seeded on Inner Surface of Alginate Hollow Microfibers

Aykar, S. S.; Alimoradi, N.; Petersen, I. S.; Montazami, R.; Brockman, A. L.; Hashemi, N. N.

10.1101/2023.01.04.522758 — bioengineering — Posted on 2023-01-04

3716 Targeted cohesin loading characterizes the entry and exit sites of loop extrusion trajectories

Han, R.; Huang, Y.; Vaandrager, I.; Allahyar, A.; Magnitov, M.; Verstegen, M. J. A. M.; de Wit, E.; Krijger, P. H. L.; de Laat, W.

10.1101/2023.01.04.522689 — genomics — Posted on 2023-01-04

3717 FAXC Proteins of Vertebrates and Invertebrates: Relationship to Metaxin Proteins

Adolph, K. W.

10.1101/2023.01.04.522723 — evolutionary biology — Posted on 2023-01-04

3718 Fluctuating environments promote evolvability by shaping adaptive variation accessible to populations

Kumawat, B.; Lalejini, A.; Acosta, M.; Zaman, L.

10.1101/2023.01.04.520634 — evolutionary biology — Posted on 2023-01-04

3719 Time-varying habitat selection analysis: a model and applications for studying diel, seasonal and post-release changes

Dejeante, R.; Valeix, M.; Chamaille-Jammes, S.

10.1101/2023.01.04.522602 — ecology — Posted on 2023-01-04

3720 Loss of NR5A1 in Sertoli cells after sex determination changes their cellular identity and induces their death by anoikis

SOUALI-CRESPO, S.; CONDREA, D.; VERNET, N.; FERET, B.; KLOPFENSTEIN, M.; GRANDGIRARD, E.; ALUNNI, V.; CERCIAT, M.; JUNG, M.; MAYERE, C.; NEF, S.; MARK, M.; CHALMEL, F.; GHYSELINCK, N. B.

10.1101/2023.01.04.522755 — developmental biology — Posted on 2023-01-04

3721 Filopodial protrusion driven by density-dependent Ena-TOCA-1 interactions

Blake, T. C. A.; Fox, H. M.; Urbancic, V.; Wolowczyk, A.; Allgeyer, E. S.; Mason, J.; Gallop, J. L.

10.1101/2023.01.04.522504 — cell biology — Posted on 2023-01-04

3722 Extensive diversity in RNA termination and regulation revealed by transcriptome mapping for the Lyme pathogen B. burgdorferi

Petroni, E.; Esnault, C.; Tetreault, D.; Dale, R. K.; Storz, G.; Adams, P. P.

10.1101/2023.01.04.522626 — microbiology — Posted on 2023-01-04

3723 In vitro ALPK1 kinase assay reveals new insights into ADP-heptose sensing pathway and kinase activity of disease-associated ALPK1 mutants

Garcia-Weber, D.; Dangeard, A.-S.; Teixeira, V.; Hauke, M.; Carreaux, A.; Josenhans, C.; Arrieumerlou, C.

10.1101/2023.01.04.522711 — immunology — Posted on 2023-01-04

3724 The study of fibrotic scar at the long term spinal cord lesion rats

Naghynajadfard, M.

10.1101/2023.01.03.522540 — neuroscience — Posted on 2023-01-04

3725 Structural circuit plasticity by a neurotrophin with a Toll modifies dopamine-dependent behaviour

SUN, J.; ULIAN-BENITEZ, S.; FORERO, M. G.; LI, G.; SINGH, D.; CACHERO, S.; ROJO-CORTES, F. R.; MOREIRA, M.; KAVANAGH, D.; JEFFERIS, G. S. X. E.; HIDALGO, A.

10.1101/2023.01.04.522695 — neuroscience — Posted on 2023-01-04

3726 Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex

Asko, O.; Blenkmann, A. O.; Leske, S. L.; Foldal, M. D.; Llorens, A.; Funderud, I.; Meling, T.; Knight, R. T.; Endestad, T.; Solbakk, A.-K.

10.1101/2023.01.04.521570 — neuroscience — Posted on 2023-01-04

3727 Distinct hypothalamus-habenula circuits govern risk preference

Groos, D.; Reuss, A. M.; Rupprecht, P.; Stachniak, T.; Han, S.; Lewis, C.; Sych, Y.; Wieckhorst, M.; Karayannis, T.; Aguzzi, A.; Helmchen, F.

10.1101/2023.01.04.522571 — neuroscience — Posted on 2023-01-04

3728 Personalized alpha-tACS targeting left posterior parietal cortex modulates visuo-spatial attention and posterior evoked EEG activity

Radecke, J.-O.; Fiene, M.; Misselhorn, J.; Herrmann, C. S.; Engel, A. K.; Wolters, C. H.; Schneider, T. R.

10.1101/2023.01.04.522700 — neuroscience — Posted on 2023-01-04

3729 Manipulating mitochondrial dynamics in the NTS prevents diet-induced deficits in brown fat morphology and activity

Fozzato, A.; New, L. E.; Griffiths, J. C.; Patel, B.; Deuchars, S. A.; Filippi, B. M.

10.1101/2023.01.04.522581 — neuroscience — Posted on 2023-01-04

3730 Cell-type-specific propagation of visual flicker

Schneider, M.; Tzanou, A.; Uran, C.; Vinck, M.

10.1101/2023.01.04.522738 — neuroscience — Posted on 2023-01-04

3731 Deep brain stimulation and dopamine medication enhance free choice preference in Parkinson's disease

Bendetowicz, D.; Temiz, G.; Hainque, E.; Czernecki, V.; Lau, B.; Karachi, C.; Munuera, J.

10.1101/2023.01.04.522610 — neuroscience — Posted on 2023-01-04

3732 p38γMAPK delays myelination and remyelination and is abundant in multiple sclerosis lesions

Marziali, L. N.; Hwang, Y.; Palmisano, M.; Cuenda, A.; Sim, F.; Volsko, C.; Dutta, R.; Trapp, B.; Wrabetz, L.; Feltri, M.

10.1101/2023.01.04.522734 — neuroscience — Posted on 2023-01-04

3733 Establishing a causal role for left ventrolateral prefrontal cortex in value-directed memory encoding with high-definition transcranial direct current stimulation

Han, L. T.; Cohen, M. S.; He, L. K.; Green, L. M.; Knowlton, B. J.; Castel, A. D.; Rissman, J.

10.1101/2023.01.04.522746 — neuroscience — Posted on 2023-01-04

3734 Understanding and evaluating ambiguity in single-cell and single-nucleus RNA-sequencing

He, D.; Soneson, C.; Patro, R.

10.1101/2023.01.04.522742 — bioinformatics — Posted on 2023-01-04

3735 A fluorogenic chemically induced dimerization technology for controlling, imaging and sensing protein proximity

Bottone, S.; Cakil, Z. V.; Joliot, O.; Boncompain, G.; Perez, F.; Gautier, A.

10.1101/2023.01.04.522617 — cell biology — Posted on 2023-01-04

3736 scRNA-seq analysis of hemocytes of penaeid shrimp under virus infection

Koiwai, K.; Kondo, H.; Hirono, I.

10.1101/2023.01.04.521844 — cell biology — Posted on 2023-01-04

3737 The interfascicular matrix of energy storing tendons houses heterogenous cell populations disproportionately affected by ageing

Zamboulis, D. E.; Marr, N.; Lenzi, L.; Birch, H. L.; Screen, H. R. C.; Clegg, P. D.; Thorpe, C. T.

10.1101/2023.01.04.522701 — cell biology — Posted on 2023-01-04

3738 Abnormal expression of Prolyl oligopeptidase (POP) and its catalytic products Ac-SDKP contributes to the ovarian fibrosis change in Polycystic ovary syndrome (PCOS) mice

Han, S.; Wang, S.; Fan, X.; Wang, X.; Huang, Y.; Zhang, H.; Ma, Y.; Wang, J.; Zhang, C.

10.1101/2023.01.04.522712 — cell biology — Posted on 2023-01-04

3739 In vivo activity of Sotrovimab against BQ.1.1 Omicron sublineage

Driouich, J.-S.; Bernadin, O.; Touret, F.; de Lamballerie, X.; Nougairede, A.

10.1101/2023.01.04.522629 — microbiology — Posted on 2023-01-04

3740 Dynamical control enables the formation of demixed biomolecular condensates

Lin, A. Z.; Ruff, K. M.; Jalihal, A. P.; Dar, F.; King, M. R.; Lalmansingh, J. M.; Posey, A. E.; Seim, I.; Gladfelter, A. S.; Pappu, R. V.

10.1101/2023.01.04.522702 — biophysics — Posted on 2023-01-04

3741 Detection of tumor-derived extracellular vesicles interactions with immune cells is dependent on EV-labelling methods

Loconte, L.; Arguedas, D.; Chipont, A.; El, R.; Guyonnet, L.; Guerin, C.; Piovesana, E.; Vazquez-Ibar, J. L.; Joliot, A.; Thery, C.; Martin Jaular, L.

10.1101/2023.01.04.522609 — cell biology — Posted on 2023-01-04

3742 HPC-Atlas: Computationally Constructing A Comprehensive Atlas of Human Protein Complexes

Pan, Y.; Li, R.; Li, W.; Lv, L.; Guan, J.; Zhou, S.

10.1101/2023.01.03.522554 — bioinformatics — Posted on 2023-01-04

3743 Bioinformatics Approaches to Determine the Effect of SARS-CoV-2 Infection on Patients with Intrahepatic Cholangiocarcinoma

Zhou, X.; Huang, T.; Yuan, K.

10.1101/2023.01.04.522709 — bioinformatics — Posted on 2023-01-04

3744 Different Coexisting Mpox Lineages Were Continuously Circulating in Humans Prior to 2022

Ndodo, N. D.; Ashcroft, J.; Lewandowski, K.; Yinka-Ogunleye, A.; Chukwu, C.; Ahmad, A.; King, D.; Akinpelu, A.; Maluquer de Motes, C.; Ribeca, P.; Sumner, R. P.; Rambaut, A.; Chester, M.; Maishman, T.; Bamidele, O.; Nwando, M.; Babatunde, O.; Aruna, O.; Pullan, S.; Gannon, B.; Brown, C.; Ihekweazu, C.; Adetifa, I.; Ulaeto, D.

10.1101/2023.01.03.522633 — microbiology — Posted on 2023-01-04

3745 Assessment of Immunogenicity and Efficacy of CV0501 mRNA-based Omicron COVID-19 Vaccination in Small Animal Models

Roth, N.; Gergen, J.; Kovacikova, K.; Mueller, S.; Ulrich, L.; Schoen, J.; Halwe, N. J.; Fricke, C.; Corleis, B.; Dorhoi, A.; Hoffmann, D.; Beer, M.; Maione, D.; Petsch, B. W.; Rauch, S.

10.1101/2023.01.04.521629 — immunology — Posted on 2023-01-04

3746 The prospect of universal coronavirus immunity: a characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses

Soni, M. K.; Migliori, E.; Fu, J.; Assal, A.; Chan, H. T.; Pan, J.; Khatiwada, P.; Ciubotariu, R.; May, M. S.; Pereira, M. R.; De Giorgi, V.; Sykes, M.; Mapara, M. Y.; Muranski, P.

10.1101/2023.01.03.519511 — immunology — Posted on 2023-01-04

3747 Effect of Nivolumab therapy on Metastatic Lung Cancer in Human Microbiome

Kubba, R.; Nguyen, S.; Borneman, J.; Pai, R.; Evans, R. J.

10.1101/2023.01.03.522679 — cancer biology — Posted on 2023-01-04

3748 The Physical Basis of Osmosis

Manning, G. S.; Kay, A. R.

10.1101/2023.01.02.522450 — biophysics — Posted on 2023-01-04

3749 EpiMix: an integrative tool for epigenomic subtyping using DNA methylation

Zheng, Y.; Jun, J.; Brennan, K.; Gevaert, O.

10.1101/2023.01.03.522660 — bioinformatics — Posted on 2023-01-04

3750 Human embryonic tanycyte: heterogeneity and developmental trajectory

Li, Y.

10.1101/2023.01.03.522431 — bioinformatics — Posted on 2023-01-04

3751 ASTK: a software for comprehensive analysis of alternative splicing

Huang, S.; He, J.; Guo, J.; Sun, Z.; Cheng, L.; Ji, X.; Zhang, Y.

10.1101/2023.01.03.522470 — bioinformatics — Posted on 2023-01-04

3752 Small cell lung cancer co-culture organoids provide insights into cancer cell survival after chemotherapy

Sen, C.; Koloff, C.; Kundu, S.; Wilkinson, D. C.; Yang, J.; Shia, D. W.; Meneses, L. K.; Rickabaugh, T. M.; Gomperts, B.

10.1101/2023.01.03.522668 — bioengineering — Posted on 2023-01-04

3753 The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma

Wilson, N. G.; Hernandez-Leyva, A.; Schwartz, D. J.; Bacharier, L. B.; Kau, A.

10.1101/2023.01.03.522677 — genomics — Posted on 2023-01-04

3754 Identification of a new antiphage system in Mycobacterium phage Butters

Mohammed, H. T.; Mageeney, C. M.; Ware, V. C.

10.1101/2023.01.03.522681 — microbiology — Posted on 2023-01-04

3755 IsoAnalytics: A Single-cell Proteomics Web Server

Zhan, X.; Palmer, S.; Koh, A. Y.

10.1101/2023.01.03.522673 — bioinformatics — Posted on 2023-01-04

3756 Control of atypical PKC{iota} membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface

Cobbaut, M.; McDonald, N. Q.; Parker, P. J.

10.1101/2023.01.03.522491 — biochemistry — Posted on 2023-01-04

3757 Relationships between mediolateral step modulation and clinical balance measures in people with chronic stroke

Howard, K. E.; Reimold, N. K.; Knight, H. L.; Embry, A. E.; Knapp, H. A.; Agne, A. A.; Jacobs, C. J.; Dean, J. C.

10.1101/2022.04.26.489530 — bioengineering — Posted on 2023-01-04

3758 No evidence of sexual conflict for a novel sperm-derived seminal fluid protein in Caenorhabditis nematodes

Kasimatis, K. R.; Rehaluk, C.; Rowe, L.; Cutter, A. D.

10.1101/2022.09.22.509081 — evolutionary biology — Posted on 2023-01-04

3759 Pelage Variation and Morphometrics of Closely Related Callithrix Marmoset Species and Their Hybrids

Malukiewicz, J.; Warren, K.; Boere, V.; Bandeira, I. L.; Curi, N. H.; das Dores, F. T.; Fitorra, L. S.; Furuya, H. R.; Igayara, C. S.; Milanelo, L.; Moreira, S. B.; Molina, C. V.; Nardi, M. S.; Nicola, P. A.; Passamani, M.; Pedro, V. S.; Pereira, L. C.; Petri, B.; Pissinatti, A.; Quirino, A. A.; Rogers, J.; Ruiz-Miranda, C. R.; Silva, D. L.; Silva, I. O.; Silva, M. O.; Suma, J. L.; Zwarg, T.; Ackermann, R. R.

10.1101/2023.01.01.522211 — zoology — Posted on 2023-01-04

3760 Cognitive exertion affects the appraisal of one's own and other people's pain

Riontino, L.; Fournier, R.; Lapteva, A.; Silvestrini, N.; Schwartz, S.; Corradi-Dell'Acqua, C.

10.1101/2022.06.09.495450 — neuroscience — Posted on 2023-01-04

3761 Liver Fibroblast Growth Factor 21 (FGF21) is Required for the Full Anorectic Effect of the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide in Male Mice fed High Carbohydrate Diets

Le, T. D. V.; Fathi, P.; Watters, A. B.; Ellis, B. J.; Bozadjieva-Kramer, N.; Perez, M. B.; Sullivan, A. I.; Rose, J. P.; Baggio, L. L.; Koehler, J.; Brown, J. L.; Bales, M. B.; Nwaba, K. G.; Campbell, J. E.; Drucker, D. J.; Potthoff, M. J.; Seeley, R. J.; Ayala, J. E.

10.1101/2023.01.03.522509 — physiology — Posted on 2023-01-04

3762 Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor.

Buigues, P. J.; Gehrke, S.; Badaoui, M.; Mandana, G.; Qi, T.; Bottegoni, G.; Rosta, E.

10.1101/2023.01.03.522558 — biophysics — Posted on 2023-01-04

3763 Emergent complexity in slowly driven stochastic processes

Costa, A. C.; Vergassola, M.

10.1101/2023.01.03.522580 — biophysics — Posted on 2023-01-04

3764 Expansion and collapse of VEGF diversity in major clades of the animal kingdom

Rauniyar, K.; Bokharaie, H.; Jeltsch, M.

10.1101/2022.09.19.507521 — evolutionary biology — Posted on 2023-01-04

3765 Heritable variation in thermoregulation is associated with reproductive success in the world's largest bird

Svensson, E. I.; Schou, M. F.; Melgar, J.; Waller, J. T.; Engelbrecht, A.; Brand, Z.; Schalk, C. C.; Cornwallis, C. K.

10.1101/2022.03.08.483498 — evolutionary biology — Posted on 2023-01-04

3766 Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase

Rees, J.; Sarangi, G.; Cheng, Q.; Floor, M.; Andres, A.; Oliva, B.; Villa-Freixa, J.; Arner, E.; Castellano, S.

10.1101/2023.01.03.522577 — molecular biology — Posted on 2023-01-04

3767 Aging Decreases the Precision of Visual Working Memory

Mohammadpour Esfahan, S.; H.K Nili, M.-H.; Sanayei, M.; Rezayat, E.

10.1101/2023.01.03.522567 — neuroscience — Posted on 2023-01-04

3768 Two modes of mid-frontal theta suggest a role in conflict and error processing

Muralidharan, V.; Aron, A. R.; Cohen, M. X.; Schmidt, R.

10.1101/2022.03.25.485421 — neuroscience — Posted on 2023-01-04

3769 Physical Activity Delays Obesity-Associated Pancreatic Ductal Adenocarcinoma in Mice and Decreases Inflammation

Pita-Grisanti, V.; Dubay, K.; Lahooti, A.; Badi, N.; Ueltschi, O.; Gumpper-Fedus, K.; Hsueh, H.-Y.; Lahooti, I.; Chavez-Tomar, M.; Terhorst, S.; Knoblaugh, S. E.; Cao, L.; Huang, W.; Coss, C. C.; Mace, T.; Choueiry, F.; Hinton, A.; Mitchell, J. M.; Schmandt, R.; Onstad Grinsfelder, M.; Basen-Engquist, K.; Cruz-Monserrate, Z.

10.1101/2023.01.03.521203 — cancer biology — Posted on 2023-01-04

3770 PIsToN: Evaluating Protein Binding Interfaces with Transformer Networks

Stebliankin, V.; Shirali, A.; Baral, P.; Chapagain, P. P.; Narasimhan, G.

10.1101/2023.01.03.522623 — bioinformatics — Posted on 2023-01-04

3771 Niche differential gene expression analysis in spatial transcriptomics data identifies context-dependent cell-cell interactions

Mason, K.; Sathe, A.; Hess, P.; Rong, J.; Wu, C.-Y.; Furth, E.; Ji, H. P.; Zhang, N.

10.1101/2023.01.03.522646 — bioinformatics — Posted on 2023-01-04

3772 Computational mutagenesis by using AUTO-MUTE 2.0 to examine X-ray crystallography structures for p53 and the impact of its resolution on predictions

Sait, S.; Vaisman, I.

10.1101/2023.01.03.522606 — bioinformatics — Posted on 2023-01-04

3773 A step towards measuring connectivity in the deep-sea: elemental fingerprints of mollusk larval shells discriminate hydrothermal sites

Mouchi, V.; Pecheyran, C.; Claverie, F.; Cathalot, C.; Matabos, M.; Rouxel, O.; Jollivet, D.; Broquet, T.; Comtet, T.

10.1101/2023.01.03.522618 — ecology — Posted on 2023-01-04

3774 Paternal morphine exposure enhances morphine self-administration and induces region-specific neural adaptations in reward-related brain regions of male offspring

Toussaint, A. B.; Ellis, A. S.; Bongiovanni, A. R.; Peterson, D. R.; Bavley, C. C.; Karbalaei, R.; Mayberry, H. L.; Bhakta, S.; Dressler, C. C.; Imperio, C. G.; Maurer, J. J.; Schmidt, H. D.; Chen, C.; Bland, K.; Liu-Chen, L.-Y.; Wimmer, M. E.

10.1101/2023.01.03.522600 — neuroscience — Posted on 2023-01-04

3775 Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

Deganutti, G.; Pipito, L.; Rujan, R. M.; Weizmann, T.; Griffin, P.; Ciancetta, A.; Moro, S.; Reynolds, C. A.

10.1101/2022.10.26.513870 — bioinformatics — Posted on 2023-01-04

3776 HiTaC: Hierarchical Taxonomic Classification of Fungal ITS Sequences

Miranda, F. M.; Azevedo, V. A. C.; Renard, B. Y.; C. Piro, V.; Ramos, R. T. J.

10.1101/2020.04.24.014852 — bioinformatics — Posted on 2023-01-04

3777 A defined community of core gut microbiota members promotes cognitive performance in honey bees

Cabirol, A.; Schafer, J.; Neuschwander, N.; Kesner, L.; Liberti, J.; Engel, P.

10.1101/2023.01.03.522593 — animal behavior and cognition — Posted on 2023-01-04

3778 Expanding risk predictions of pesticide resistance evolution in arthropod pests with a proxy for selection pressure

Thia, J. A.; Maino, J.; Kelly, A.; Hoffmann, A. A.; Umina, P. A.

10.1101/2022.04.18.488707 — evolutionary biology — Posted on 2023-01-04

3779 Pan-genome study underling the extent of genomic variation of invasive Streptococcus pneumoniae in Malawi

Iranzadeh, A.; Alisoltani, A.; Kiran, A.; Breiman, R.; Chaguza, C.; Peno, C.; Cornick, J. E.; Everett, D. B.; Mulder, N.

10.1101/2023.01.02.522535 — microbiology — Posted on 2023-01-04

3780 Modelling the stable subspace of distributed brain responses in stimulus processing

Vidaurre, D.

10.1101/2023.01.03.522583 — neuroscience — Posted on 2023-01-04

3781 Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway

Kin, K.; Kano, S.-i.; Niwa, M.

10.1101/2023.01.03.522598 — neuroscience — Posted on 2023-01-04

3782 Representational geometry explains puzzling error distributions in behavioral tasks

Wei, X.-X.; Woodford, M.

10.1101/2023.01.03.522667 — neuroscience — Posted on 2023-01-04

3783 Tool-sensed object information effectively supports vision for multisensory grasping

Camponogara, I.; Farne', A.; Volcic, R.

10.1101/2023.01.03.522671 — neuroscience — Posted on 2023-01-04

3784 Drifting representation with transient resets characterizes sensorimotor transformation in the monkey superior colliculus

Heusser, M. R.; Jagadisan, U. K.; Gandhi, N. J.

10.1101/2023.01.03.522634 — neuroscience — Posted on 2023-01-04

3785 Running ahead of evolution - AI based simulation for predicting future high-risk SARS-CoV-2 variants

Chen, J.; Nie, Z.; Wang, Y.; Wang, K.; Xu, F.; Hu, Z.; Zheng, B.; Wang, Z.; Song, G.; Zhang, J.; Fu, J.; Huang, X.; Wang, Z.; Ren, Z.; Wang, Q.; Li, D.; Wei, D.; Zhou, B.; Yang, C.; Tian, Y.

10.1101/2022.11.17.516989 — bioinformatics — Posted on 2023-01-04

3786 Flexible and scalable control of T cell memory by a reversible epigenetic switch

Abadie, K.; Clark, E.; Ukogu, O.; Yang, W.; Daza, R.; Ng, K. K. H.; Fathima, J.; Wang, A.; Bhandoola, A.; Nourmohammad, A.; Shendure, J.; Cao, J.; Kueh, H. Y.

10.1101/2022.12.31.521782 — immunology — Posted on 2023-01-04

3787 COVID-associated pulmonary aspergillosis in immunocompetent patients

Ribeiro, H. A. L.; Scindia, Y.; Mehrad, B.; Laubenbacher, R.

10.1101/2022.07.18.500514 — systems biology — Posted on 2023-01-04

3788 Metrics of Coral Microfragment Viability

Lager, C.; Perry, R.; Daly, J.; Page, C.; Mizobe, M.; Bouwmeester, J.; Consiglio, A.; Powell-Palm, M. J.; Hagedorn, M.

10.1101/2023.01.03.522625 — cell biology — Posted on 2023-01-03

3789 Dock7 regulates AKT and mTOR/S6K activity required for the transformed phenotypes and survival of cancer cells

Teran, O. Y.; Zanotelli, M. R.; Lin, M.-c. J.; Cerione, R. A.; Wilson, K. F.

10.1101/2023.01.03.522657 — cancer biology — Posted on 2023-01-03

3790 An RNA seq-based reference landscape of human normal and neoplastic brain

Arora, S.; Szulzewsky, F.; Jensen, M.; Nuechterlein, N.; Pattwell, S. S.; Holland, E. C.

10.1101/2023.01.03.522658 — bioinformatics — Posted on 2023-01-03

3791 Evolution of explorative and exploitative search strategies in collective foraging

Garg, K.; Smaldino, P. E.; Kello, C. T.

10.1101/2023.01.03.522515 — animal behavior and cognition — Posted on 2023-01-03

3792 Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells

Katsuda, T.; Li, J.; Merrell, A. J.; Sussman, J.; Matsuzaki, J.; Ochiya, T.; Stanger, B. Z.

10.1101/2023.01.03.522656 — cell biology — Posted on 2023-01-03

3793 A dynamic partitioning mechanism polarizes membrane protein distribution

Banerjee, T.; Matsuoka, S.; Biswas, D.; Miao, Y.; Pal, D. S.; Kamimura, Y.; Ueda, M.; Devreotes, P. N.; Iglesias, P. A.

10.1101/2023.01.03.522496 — cell biology — Posted on 2023-01-03

3794 Epithelioids: Self-sustaining 3D epithelial cultures to study long-term processes

Herms, A.; Fernandez-Antoran, D.; Alcolea, M.; Kalogeropoulou, A.; Banerjee, U.; Piedrafita, G.; Abby, E.; Valverde-Lopez, J. A.; Ferreira, I. S.; Dentro, S.; Ong, S. H.; Colom, B.; Murai, K.; King, C.; Mahbubani, K. T.; Saeb-Parsy, K.; Lowe, A. R.; Gerstung, M.; Jones, P. H.

10.1101/2023.01.03.522589 — cell biology — Posted on 2023-01-03

3795 Stepwise molecular specification of excitatory synapse diversity on a target neuron

Paul, M. A.; Sigoillot, S. M.; Marti, L.; Delagrange, M.; Mailly, P.; Selimi, F.

10.1101/2023.01.03.521946 — neuroscience — Posted on 2023-01-03

3796 Hypersensitivity to distractors in Fragile X syndrome from loss of modulation of cortical VIP interneurons.

Rahmatullah, N.; Schmitt, L.; DeStefano, L.; Post, S.; Chaudhari, G.; Robledo, J.; Pedapati, E.; Erickson, C.; Portera-Cailliau, C.; Goel, A.

10.1101/2023.01.03.522654 — neuroscience — Posted on 2023-01-03

3797 AlphaFold2 can predict structural and phenotypic effects of single mutations

Mcbride, J. M.; Reinharz, V.; Polev, K.; Grzybowski, B. A.; Tlusty, T.

10.1101/2022.04.14.488301 — biochemistry — Posted on 2023-01-03

3798 LoxCode in vivo clonal barcoding resolves mammalian epiblast contribution to fetal organs

Weber, T. S.; Biben, C.; Miles, D. C.; Zhang, S.; Tam, P.; Taoudi, S.; Naik, S. H.

10.1101/2023.01.02.522501 — developmental biology — Posted on 2023-01-03

3799 Mice generated with induced pluripotent stem cells derived from mucosal-associated invariant T cells

Sugimoto, C.; Fujita, H.; Wakao, H.

10.1101/2022.07.27.501791 — immunology — Posted on 2023-01-03

3800 HydRA: Deep-learning models for predicting RNA-binding capacity from protein interaction association context and protein sequence

Jin, W.; Brannan, K. W.; Kapeli, K.; Park, S. S.; Tan, H. Q.; Gosztyla, M. L.; Mujumdar, M.; Ahdout, J.; Henroid, B.; Rothamel, K.; Xiang, J. S.; Wong, L.; Yeo, G. W.

10.1101/2022.12.23.521837 — bioinformatics — Posted on 2023-01-03

3801 Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotype.

Lawler, P. E.; Bollinger, J. G.; Schindler, S. E.; Hodge, C. R.; Iglesias, N. J.; Krishnan, V.; Coulton, J. B.; Li, Y.; Holtzman, D. M.; Bateman, R. J.

10.1101/2023.01.03.522616 — biochemistry — Posted on 2023-01-03

3802 Deleterious effects of thermal and water stresses on life history and physiology: a case study on woodlouse

DEPEUX, C.; BRANGER, A.; MOULIGNIER, T.; MOREAU, J.; Lemaitre, J.-F.; DECHAUME-MONCHARMONT, F.-X.; LAVERRE, T.; PAULHAC, H.; GAILLARD, J.-M.; BELTRAN-BECH, S.

10.1101/2022.09.26.509512 — evolutionary biology — Posted on 2023-01-03

3803 Site-suitability difference and the expectation of species richness difference in stochastic two-subcommunity models

Iritani, R.

10.1101/2023.01.01.522407 — ecology — Posted on 2023-01-03

3804 DNA metabarcoding reveals the dietary profiles of a benthic marine crustacean, Nephrops norvegicus

Shum, P.; Wäge-Recchioni, J.; Sellers, G. S.; Johnson, M. L.; Joyce, D. A.

10.1101/2022.12.14.520264 — ecology — Posted on 2023-01-03

3805 The C. elegans Anchor Cell Transcriptome: Ribosome Biogenesis Drives Cell Invasion through Basement Membrane

Costa, D. S.; Kenny-Ganzert, I. W.; Chi, Q.; Park, K.; Kelley, L. C.; Garde, A.; Matus, D. Q.; Park, J.; Yogev, S.; Goldstein, B.; Gibney, T. V.; Pani, A. M.; Sherwood, D. R.

10.1101/2022.12.28.522136 — cell biology — Posted on 2023-01-03

3806 gp120 envelope glycoproteins of HIV-1 Group M Subtype A and Subtype B differentially affect gene expression in human vascular endothelial cells

Suh, A. J.; Suzuki, D. I.; Gychka, S. G.; Brelidze, T. I.; Suzuki, Y. J.

10.1101/2023.01.03.522636 — cell biology — Posted on 2023-01-03

3807 Blocking abundant RNA transcripts by high-affinity oligonucleotides during transcriptome library preparation

Verwilt, J.; Everaert, C.; Verniers, K.; Vandamme, N.; Rubio, A. M.; Vandesompele, J.; Mestdagh, P.

10.1101/2022.03.11.483910 — molecular biology — Posted on 2023-01-03

3808 Variability in training unlocks generalization in visual perceptual learning through invariant representations

Manenti, G. L.; Dizaji, A. S.; Schwiedrzik, C. M.

10.1101/2022.08.26.505408 — neuroscience — Posted on 2023-01-03

3809 Decoding the relative contributions of extrinsic and intrinsic mechanisms in mediating heterogeneous spiking activities of sensory neurons in vivo using computational modeling

Akhshi, A.; Haggard, M.; Marquez Machorro, M.; Farjami, S.; Chacron, M. J.; Khadra, A.

10.1101/2023.01.03.521866 — neuroscience — Posted on 2023-01-03

3810 An original potentiating mechanism revealed by the cryoEM structures of the human α7 nicotinic receptor in complex with nanobodies

Prevost, M. S.; Barilone, N.; Dejean de la Batie, G.; Pons, S.; Ayme, G.; England, P.; Gielen, M.; Bontems, F.; Pehau-Arnaudet, G.; Maskos, U.; Lafaye, P.; Corringer, P.-J.

10.1101/2023.01.03.522595 — neuroscience — Posted on 2023-01-03

3811 Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization

Goldblatt, D.; Huang, S.; Greaney, M. R.; Hamling, K. R.; Voleti, V.; Perez-Campos, C.; Patel, K. B.; Li, W.; Hillman, E. M. C.; Bagnall, M. W.; Schoppik, D.

10.1101/2022.10.21.513243 — neuroscience — Posted on 2023-01-03

3812 Combined genome-scale fitness and paralog synthetic lethality screens with just 44k clones: the IN4MER CRISPR/Cas12a multiplex knockout platform

Esmaeili Anvar, N.; Lin, C.; Wilson, L. L.; Sangree, A. K.; Ma, X.; Colic, M.; Doench, J. G.; Hart, T.

10.1101/2023.01.03.522655 — systems biology — Posted on 2023-01-03

3813 Boolean modeling of mechanosensitive Epithelial to Mesenchymal Transition and its reversal

Sullivan, E.; Harris, M.; Bhatnagar, A.; Guberman, E.; Zonfa, I.; Ravasz Regan, E.

10.1101/2022.08.29.505701 — systems biology — Posted on 2023-01-03

3814 HSV-1 Oncolytic Virus Targeting CEACAM6-Expressing Tumors Using a Bispecific T-Cell Engager

Murad, Y. M.; Lee, I.-F.; Liu, X.; Delwar, Z.; Ding, J.; Liu, G.; Tatsiy, O.; Chouljenko, D.; Hussack, G.; Van Faassen, H.; Jia, W. W.-G.

10.1101/2023.01.02.522257 — cancer biology — Posted on 2023-01-03

3815 Reconstructing the functional effect of TP53 somatic mutations on its regulon using causal signalling network modelling

Triantafyllidis, C.; Barberis, A.; Miar, A.; Chartlon, P.; Hartley, F.; Van Bijsterveldt, L.; Gjerga, E.; Saez-Rodriguez, J.; Buffa, F. M.

10.1101/2022.06.23.497293 — cancer biology — Posted on 2023-01-03

3816 The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding

Bennett, J. A.; Steward, L. R.; Voss, A.; Rudolph, J.; Aydin, H.

10.1101/2022.04.21.489104 — biophysics — Posted on 2023-01-03

3817 Development and validation of a type 2 diabetes machine learning classification model for EHR-based diagnostics and clinical decision support

Glanz, V.; Dudenkov, V.; Velikorodny, A.

10.1101/2022.10.08.511400 — bioinformatics — Posted on 2023-01-03

3818 MASH Native: A Unified Solution for Native Top-Down Proteomics Data Processing

Larson, E. J.; Pergande, M. R.; Moss, M. E.; Rossler, K. J.; Wenger, R. K.; Krichel, B.; Josyer, H.; Melby, J. A.; Roberts, D. S.; Pike, K.; Shi, Z.; Chan, H.-J.; Knight, B. A.; Rogers, H. T.; Brown, K. A.; Ong, I. M.; Jeong, K.; Marty, M. T.; McIlwain, S. J.; Ge, Y.

10.1101/2023.01.02.522513 — bioinformatics — Posted on 2023-01-03

3819 CopyMix: Mixture Model Based Single-Cell Clustering and Copy Number Profiling using Variational Inference

Safinianaini, N.; P. E. de Souza, C.; Roth, A.; Koptagel, H.; Toosi, H.; Lagergren, J.

10.1101/2020.01.29.926022 — bioinformatics — Posted on 2023-01-03

3820 Strategies for increasing the depth and throughput of protein analysis by plexDIA

Derks, J.; Slavov, N.

10.1101/2022.11.05.515287 — bioengineering — Posted on 2023-01-03

3821 A high-throughput machine vision-based univariate scale for pain and analgesia in mice

Sabnis, G. S.; Hession, L. E.; Kim, K.; Beierle, J. A.; Kumar, V. A.

10.1101/2022.12.29.522204 — animal behavior and cognition — Posted on 2023-01-03

3822 Isolation by Distance in Populations with Power-law Dispersal

Smith, T. B.; Weissman, D. B.

10.1101/2020.06.24.168211 — evolutionary biology — Posted on 2023-01-03

3823 Holobiont Evolution: Model of Phage/Bacteria Dynamics With Implications for the Lytic to Lysogenic Transition

Roughgarden, J.

10.1101/2023.01.03.522622 — ecology — Posted on 2023-01-03

3824 Macrophage activation drives ovarian failure and masculization

Bravo, P.; Liu, Y.; Draper, B. W.; Marlow, F.

10.1101/2023.01.03.522645 — developmental biology — Posted on 2023-01-03

3825 Molecular architecture of the ciliary tip revealed by cryo-electron tomography

Legal, T.; Tong, M.; Black, C.; Valente-Paterno, M.; Gaertig, J.; Bui, K. H.

10.1101/2023.01.03.522627 — cell biology — Posted on 2023-01-03

3826 Transcription factor AhR regulates glutathione S-transferases (GSTs) conferring resistance to lambda-cyhalothrin in Cydia pomonella

Hu, C.; Liu, Y.-X.; Zhang, S.-P.; Wang, Y.-Q.; Gao, P.; Li, Y.-T.; Yang, X.

10.1101/2023.01.03.522531 — molecular biology — Posted on 2023-01-03

3827 AedG, a new weapon in Acinetobacters fight against antimicrobials

Hassan, K. A.; Naidu, V. N.; Shah, B.; Maher, C.; Paulsen, I. T.

10.1101/2023.01.03.522653 — microbiology — Posted on 2023-01-03

3828 Identification of two distinct phylogenomic lineages and model strains for the understudied cystic fibrosis lung pathogen Burkholderia multivorans

Parfitt, K. M.; Green, A. E.; Connor, T. R.; Neill, D. R.; Mahenthiralingam, E.

10.1101/2023.01.03.522605 — microbiology — Posted on 2023-01-03

3829 Application of nanopore sequencing for accurate identification of bacterial colonies

Marshall, A.; Fuller, D. T.; Dougall, P.; Kumaragama, K.; Dhaniyala, S.; Sur, S.

10.1101/2023.01.03.522650 — microbiology — Posted on 2023-01-03

3830 Nirmatrelvir Resistance in SARS-CoV-2 Omicron_BA.1 and WA1 Replicons and Escape Strategies

Lan, S.; Neilsen, G.; Slack, R. L.; Cantara, W. A.; Emanuelli Castaner, A.; Lorson, Z. C.; Lulkin, N. D.; Zhang, H.; Lee, J.; Cilento, M. E.; Tedbury, P. R.; Sarafianos, S. G.

10.1101/2022.12.31.522389 — microbiology — Posted on 2023-01-03

3831 mRNA delivery of dimeric human IgA protects mucosal tissues from bacterial infection

Deal, C. E.; Richards, A. F.; Yeung, T.; Maron, M. J.; Wang, Z.; Lai, Y.-T.; Fritz, B. R.; Himansu, S.; Narayanan, E.; Liu, D.; Koleva, R.; Licht, S.; Hsiao, C. J.; Rajlic, I. L.; Koch, H.; Kleyman, M.; Pulse, M. E.; Weiss, W. J.; Doering, J. E.; Lindberg, S. K.; Mantis, N. J.; Carfi, A.; Plante, O. J.

10.1101/2023.01.03.521487 — immunology — Posted on 2023-01-03

3832 Multiomics atlas-assisted discovery of transcription factors enables specific cell state programming.

Chung, H. K.; Liu, C.; Casillas, E.; Mcdonald, B.; Wang, J.; Sun, M.; Ma, S.; Chen, D.; Chick, B.; Yang, Q.; Hoffmann, F.; Varanasi, S. K.; Tripple, V.; Cho, U. H.; Ho, J.; Hang, Y.; Williams, A.; Hargreaves, D.; Kaech, S. M.; Wang, W.

10.1101/2023.01.03.522354 — immunology — Posted on 2023-01-03

3833 Functional Organization of Auditory and Reward Systems in Healthy Aging

Belden, A.; Quinci, M. A.; Geddes, M. R.; Hanser, S. B.; Donovan, N. J.; Loui, P.

10.1101/2023.01.01.522417 — neuroscience — Posted on 2023-01-03

3834 The human brain reactivates context-specific past information at event boundaries of naturalistic experiences

Hahamy, A.; Dubossarsky, H.; Behrens, T. E. J.

10.1101/2022.06.13.495935 — neuroscience — Posted on 2023-01-03

3835 Mitochondrial genes in the 22q11.2 deleted region regulate neural stem and progenitor cell proliferation

Campbell, P. D.; Lee, I.; Thyme, S.; Granato, M.

10.1101/2023.01.03.522615 — neuroscience — Posted on 2023-01-03

3836 Brain state and cortical layer-specific mechanisms underlying perception at threshold

Morton, M. P.; Denagamage, S.; Blume, I. J.; Reynolds, J. H.; Jadi, M. P.; Nandy, A. S.

10.1101/2021.11.16.468866 — neuroscience — Posted on 2023-01-03

3837 Neural activity in the anterior cingulate cortex is required for effort-based decision making

Kashay, A. Q.; Cheung, J. Y.; Vaknalli, R. N.; Delaney, M. J.; Navarro, M. B.; Junaidi, C.; Veenker, F.; Neuwirth, M. E.; Gabriel, C. J.; DeNardo, L. A.; Wilke, S. A.

10.1101/2022.03.22.485350 — neuroscience — Posted on 2023-01-03

3838 An Automated Scientist to Design and Optimize Microbial Strains for the Industrial Production of Small Molecules

Singh, A. H.; Kaufmann-Malaga, B. B.; Lerman, J. A.; Dougherty, D. P.; Zhang, Y.; Kilbo, A. L.; Wilson, E. H.; Ng, C. Y.; Erbilgin, O.; Curran, K. A.; Reeves, C. D.; Hung, J. E.; Mantovani, S.; King, Z. A.; Ayson, M.; Denery, J. R.; Lu, C.-W.; Norton, P.; Tran, C.; Platt, D. M.; Cherry, J. R.; Chandran, S. S.; Meadows, A. L.

10.1101/2023.01.03.521657 — synthetic biology — Posted on 2023-01-03

3839 A critical role of retinoic acid concentration for the induction of a fully human-like atrial phenotype in hiPSC-CM

Schulz, C.; Soenmez, M.; Krause, J.; Schwedhelm, E.; Bangfen, P.; Alihodzic, D.; Hansen, A.; Eschenhagen, T.; Christ, T.

10.1101/2023.01.03.522611 — pharmacology and toxicology — Posted on 2023-01-03

3840 Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis

Gui, Y.; Tao, J.; Wang, Y.; Palanza, Z.; Qiao, Y.; Hargis, G.; Kreutzer, D. L.; Liu, S.; Bastacky, S.; Wang, Y.; Yu, Y.; Fu, H.; Zhou, D.

10.1101/2023.01.03.522608 — pathology — Posted on 2023-01-03

3841 Mammary-specific ectopic expression of mutant human GATA3 did not potentiate medroxyprogesterone acetate-driven mouse mammary tumorigenesis

Lofgren, K. A.; Kenny, P. A.

10.1101/2023.01.03.522644 — cancer biology — Posted on 2023-01-03

3842 Cooperative NF-κB and Notch1 signaling promotes macrophage-mediated MenaINV expression in breast cancer

Duran, C. L.; Karagiannis, G. S.; Chen, X.; Sharma, V. P.; Entenberg, D.; Condeelis, J. S.; Oktay, M. H.

10.1101/2023.01.03.522642 — cancer biology — Posted on 2023-01-03

3843 MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis

DeRollo, R. E.; Cazarin, J.; Ahmad Shahidan, S. N. A. B.; Burchett, J. B.; Mwangi, D.; Krishnaiah, S.; Hsieh, A. L.; Walton, Z. E.; Brooks, R.; Mello, S. S.; Weljie, A. M.; Dang, C. V.; Altman, B. J.

10.1101/2023.01.03.522637 — cancer biology — Posted on 2023-01-03

3844 Structure of pre-miR-31 reveals an active role in Dicer processing

Ma, S.; Kotar, A.; Grote, S.; Rouskin, S.; Keane, S. C.

10.1101/2023.01.03.519659 — biophysics — Posted on 2023-01-03

3845 Structural mechanism of LIN28B nucleosome targeting by OCT4 for pluripotency

Guan, R.; Lian, T.; Zhou, B.-R.; Bai, Y.

10.1101/2023.01.03.522631 — biophysics — Posted on 2023-01-03

3846 Crystal structure of a mammalian CMTM6 and its interaction model with PD-L1

Zhang, S.; Xie, Q.; Fu, C.; Luo, Y.; Sun, Z.; Zhou, X.

10.1101/2023.01.03.522599 — biophysics — Posted on 2023-01-03

3847 Structural and Dynamical Properties of Elastin-Like Peptides near their Lower Critical Solution Temperature

Morozova, T. I.; Garcia, N. A.; Matsarskaia, O.; Roosen-Runge, F.; Barrat, J.-L.

10.1101/2022.09.25.509363 — biophysics — Posted on 2023-01-03

3848 Computing absolute binding affinities by Streamlined Alchemical Free Energy Perturbation

Santiago-McRae, E.; Ebrahimi, M.; Sandberg, J. W.; Brannigan, G.; Henin, J.

10.1101/2022.12.09.519809 — biophysics — Posted on 2023-01-03

3849 Sequence-to-sequence translation from mass spectra to peptides with a transformer model

Fondrie, W. E.; Yilmaz, M.; Bittremieux, W.; Nelson, R.; Ananth, V.; Oh, S.; Noble, W. S.

10.1101/2023.01.03.522621 — bioinformatics — Posted on 2023-01-03

3850 Control of atypical PKC{iota} membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface

Cobbaut, M.; McDonald, N. Q.; Parker, P. J.

10.1101/2023.01.03.522491 — biochemistry — Posted on 2023-01-03

3851 Crosstalk between chromatin and the transcription factor Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage.

Mancheno-Ferris, A.; IMMARIGEON, C.; Rivero, A.; Depierre, D.; Chanard, N.; Fosseprez, O.; Aughey, G.; Lhoumaud, P.; Anglade, J.; Southall, T.; plaza, s.; Cuvier, O.; Payre, F.; Polesello, C.

10.1101/2023.01.03.522588 — genomics — Posted on 2023-01-03

3852 Building pangene sets from plant genome alignments confirms presence-absence variation

Contreras-Moreira, B.; Saraf, S.; Naamati, G.; Amberkar, S. S.; Flicek, P.; Jones, A. R.; Dyer, S.

10.1101/2023.01.03.520531 — genomics — Posted on 2023-01-03

3853 The genetic architecture of the human skeletal form

Kun, E.; Javan, E. M.; Smith, O.; Gulamali, F.; Fuente, J. d. l.; Flynn, B. I.; Vajrala, K.; Trutner, Z.; Jayakumar, P.; Tucker-Drob, E. M.; Sohail, M.; Singh, T.; Narasimhan, V. M.

10.1101/2023.01.03.521284 — genomics — Posted on 2023-01-03

3854 L-shape distribution of the relative substitution rate (c micro) observed for SARS-COV-2 genome, inconsistent with the selectionist theory, the neutral theory and the nearly neutral theory but a near-neutral balanced selection theory: implication on neutralist-selectionist debate

Wu, C.; Paradis, N.; Lakernick, P.; Hryb, M.

10.1101/2023.01.01.522435 — evolutionary biology — Posted on 2023-01-03

3855 Reduced effectiveness of purifying selection on new mutations in a parthenogenic terrestrial isopod (Trichoniscus pusillus)

Yarbrough, E.; Chandler, C.

10.1101/2023.01.03.522635 — evolutionary biology — Posted on 2023-01-03

3856 Foraging guild modulates insectivorous bat responses to habitat loss and insular fragmentation in peninsular Malaysia

Hazard, Q. C. K.; Froidevaux, J. S. P.; Yoh, N.; Moore, J.; Senawi, J.; Gibson, L.; Palmeirim, A. F.

10.1101/2023.01.03.522569 — ecology — Posted on 2023-01-03

3857 The myocardium utilizes Pdgfra-PI3K signaling to steer towards the midline during heart tube formation

Shrestha, R.; McCann, T.; Saravanan, H.; Lieberth, J.; Koirala, P.; Bloomekatz, J.

10.1101/2023.01.03.522612 — developmental biology — Posted on 2023-01-03

3858 Enhanced transmissibility of XBB.1.5 is contributed by both strong ACE2 binding and antibody evasion

Yue, C.; Song, W.; Wang, L.; Jian, F.; Chen, X.; Gao, F.; Shen, Z.; Wang, Y.; Wang, X.; Cao, Y. R.

10.1101/2023.01.03.522427 — immunology — Posted on 2023-01-03

3859 Nanoparticle-Conjugated TLR9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 Vaccines

Ou, B. S.; Picece, V. C. T. M.; Baillet, J.; Gale, E. C.; Powell, A. E.; Saouaf, O. M.; Yan, J.; Lopez Hernandez, H.; Appel, E.

10.1101/2023.01.02.522505 — immunology — Posted on 2023-01-03

3860 In-silico monitoring of directed evolution convergence to unveil best performing variants with credibility score

Nemoto, T.; Ocari, T.; Planul, A.; Tekinsoy, M.; Zin, E. A.; Dalkara, D.; Ferrari, U.

10.1101/2023.01.03.522172 — bioinformatics — Posted on 2023-01-03

3861 HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

Chu, L.; Chen, Y.; Qian, L.; Zhu, J.; Meng, W.; Wang, Q.; Wang, C.; Cui, S.

10.1101/2023.01.03.522548 — immunology — Posted on 2023-01-03

3862 Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2s.

Taniuchi, I.; Nomura, A.; Oishi, M. O.; Kobayashi, T.; Seo, W.; Kakugawa, K.; Muroi, S.; Yoshida, H.; Endo, T.; Moro, K.

10.1101/2023.01.03.522551 — immunology — Posted on 2023-01-03

3863 Experiments in micro-patterned model membranes support the narrow escape theory

Meiser, E.; Mohammadi, R.; Vogel, N.; Holcman, D.; Fenz, S. F.

10.1101/2023.01.03.521408 — biophysics — Posted on 2023-01-03

3864 Structural insights into ion conduction by novel cation channel, TMEM87A, in Golgi apparatus

Han, A.-r.; Zhang, A.; Kang, H.; Maria Solano, M. A.; Yang, J.; Lee, C. J.; Choi, S.; Kim, H. M.

10.1101/2023.01.03.522544 — biophysics — Posted on 2023-01-03

3865 Integrated Bioinformatics Analysis Reveals APEX1 as a Potential Biomarker for Septic Cardiomyopathy

Pu, J.; Gao, F.; He, Y.

10.1101/2023.01.03.522553 — bioinformatics — Posted on 2023-01-03

3866 Rare catechol-O-methyltransferase (COMT) missense variants are structurally unstable proteasome targets

Larsen, F. B.; Cagiada, M.; Dideriksen, J.; Stein, A.; Lindorff-Larsen, K.; Hartmann-Petersen, R.

10.1101/2023.01.03.522480 — biochemistry — Posted on 2023-01-03

3867 Dissecting the respective roles of microbiota and host genetics in the susceptibility of Card9-/- mice to colitis

Danne, C.; Lamas, B.; Lavelle, A.; Michel, M.-L.; Da-Costa, G.; Pham, H.-P.; Lefevre, A.; Bridonneau, C.; Bredon, M.; Planchais, J.; Straube, M.; Emond, P.; Langella, P.; Sokol, H.

10.1101/2023.01.03.522555 — genetics — Posted on 2023-01-03

3868 Phylogenetic comparative approach reveals evolutionary conservatism, ancestral composition, and integration of vertebrate gut microbiota

Perez-Lamarque, B.; Sommeria-Klein, G.; Duret, L.; Morlon, H.

10.1101/2023.01.03.522549 — evolutionary biology — Posted on 2023-01-03

3869 TOBF1 modulates mouse embryonic stem cell fate through co-transcriptional regulation of alternative splicing

Chakraborty, D.; Aich, M.; Ansari, A. H.; Ding, L.; Iesmantavicius, V.; Paul, D.; Choudhary, C.; Maiti, S.; Buchholz, F.

10.1101/2023.01.03.522557 — developmental biology — Posted on 2023-01-03

3870 Multi-omics analysis reveals the regulatory mechanism of flavonol biosynthesis during the formation of petal color in Camellia nitidissima

Feng, Y.; Li, J.; Chu, X.; Yin, H.; Fan, Z.; Yu, S.; Minyan, W.; Li, X.; Liu, W.

10.1101/2023.01.03.522545 — molecular biology — Posted on 2023-01-03

3871 GolpHCat (TMEM87A): a unique voltage-gated and pH-sensitive cation channel in the Golgi

Kang, H.; Jeong, H.; Han, A.-R.; Koh, W.; Lee, J. M.; Jo, H.; Lee, H.; Bhalla, M.; Roh, W. S.; Jang, H. J.; Lee, B.; Kim, H. M.; An, H. J.; Lee, C. J.

10.1101/2023.01.03.522543 — molecular biology — Posted on 2023-01-03

3872 Consistency across multi-omics layers in a drug-perturbed gut microbial community

Wuyts, S.; Alves, R.; Zimmermann-Kogadeeva, M.; Nishijima, S.; Blasche, S.; Driessen, M.; Geyer, P. E.; Hercog, R.; Kartal, E.; Maier, L.; Müller, J. B.; Garcia Santamarina, S.; Schmidt, T. S. B.; Sevin, D. C.; Telzerow, A.; V. Treit, P.; Wenzel, T.; Typas, A.; R. Patil, K.; Mann, M.; Kuhn, M.; Bork, P.

10.1101/2023.01.03.519475 — microbiology — Posted on 2023-01-03

3873 CCR1 Mediates Müller Cell Activation and Photoreceptor Cell Death in Macular and Retinal Degeneration

Elbaz-Hayoun, S.; Rinsky, B.; Hagbi-Levi, S.; Grunin, M.; Chowers, I.

10.1101/2023.01.03.522541 — immunology — Posted on 2023-01-03

3874 Innovative Research Experiences for Underrepresented Undergraduates: A Collaborative STEM Research Program as a Pathway to Graduate School

Hacisalihoglu, G.

10.1101/2023.01.03.522432 — scientific communication and education — Posted on 2023-01-03

3875 Glycoprofiling of Cartilage Matrix-Forming Tumours.

McClure, J.; McClure, S. F.

10.1101/2023.01.03.522552 — pathology — Posted on 2023-01-03

3876 Establishment of primary renal lymphoma model and the clinical relevance

Li, X.; Deng, M.; Zhang, C.; Luo, L.; Qian, H.

10.1101/2023.01.03.522576 — cancer biology — Posted on 2023-01-03

3877 Fatty Acid Vesicles as Hard UV-C Shields for Early Life

Lechuga, I.; Michaelian, K.

10.1101/2023.01.01.522439 — biophysics — Posted on 2023-01-03

3878 Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor.

Buigues Jorro, P. J.; Gehrke, S.; Badaoui, M.; Mandana, G.; Qi, T.; Bottegoni, G.; Rosta, E.

10.1101/2023.01.03.522558 — biophysics — Posted on 2023-01-03

3879 EVALUATION AND COMPARISON OF THE ANTIOXIDANT AND FREE RADICAL SCAVENGING PROPERTIES OF MEDICINAL PLANTS BY USING THE DPPH ASSAY IN-VITRO

Yousaf, H.

10.1101/2023.01.03.522539 — biochemistry — Posted on 2023-01-03

3880 SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression

Naeli, P.; Zhang, X.; Harris Snell, P.; Chatterjee, S.; Kamran, M.; Ladak, R. J.; Orr, N.; Duchaine, T.; Sonenberg, N.; Jafarnejad, S. M.

10.1101/2023.01.01.522328 — cell biology — Posted on 2023-01-03

3881 ErbB inhibition impairs cognition via disrupting myelination and aerobic glycolysis in oligodendrocytes

Hu, X.; Zhu, Q.; Lou, T.; Hu, Q.; Niu, X.; He, L.; Huang, H.; Xu, Y.; Qiu, M.; Shen, Y.; Jia, J.-M.; Tao, Y.

10.1101/2023.01.03.522525 — neuroscience — Posted on 2023-01-03

3882 Composition of nasopharyngeal microbiota in individuals with SARS-COV-2 infection across three COVID-19 waves in India

Bose, T.; Wasimuddin, ; Acharya, V.; Pinna, N. K.; Kaur, H.; Ranjan, M.; Jhandylala, S.; Nagabandi, T.; Varma, B.; Tallapaka, K. B.; Sowpati, D. T.; Haque, M. M.; Dutta, A.; Siva, A. B.; Mande, S. S.

10.1101/2023.01.02.522449 — microbiology — Posted on 2023-01-03

3883 A Gamma-adapted recombinant subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from SARS-CoV-2 infection.

10.1101/2023.01.03.522213 — immunology — Posted on 2023-01-03

3884 Time Dependent Dihedral Angle Oscillations of the Spike Protein of SARS-CoV-2 Reveal Favored Frequencies of Dihedral Angle Rotations

Bastidas, O. H.

10.1101/2023.01.02.522466 — biophysics — Posted on 2023-01-03

3885 Investigation of the Impact of Clonal Hematopoiesis on Severity and Pathophysiology of COVID-19 in Rhesus Macaques

Shin, T.-H.; Zhou, Y.; Lee, B.-C.; Hong, S. G.; Andrew, S. F.; Flynn, B. J.; Gagne, M.; Todd, J.-P. M.; Moore, I. N.; Cook, A.; Lewis, M. G.; Foulds, K. E.; Seder, R. A.; Doueck, D. C.; Roederer, M.; Dunbar, C. E.

10.1101/2023.01.01.522064 — genetics — Posted on 2023-01-03

3886 Metabolic rewiring of the probiotic bacterium Lacticaseibacillus rhamnosus GG contributes to cell wall remodeling and antimicrobials production

Suissa, R.; Olender, T.; Malitsky, S.; Golani, O.; Turjeman, S.; Meijler, M. M.; Koren, O.; Kolodkin-Gal, I.

10.1101/2023.01.03.522566 — microbiology — Posted on 2023-01-03

3887 Pathogen and human NDPK-proteins promote AML cell survival via monocyte NLRP3-inflammasome activation.

Trova, S.; Lin, F.; Lomada, S.; Fenton, M.; Chauhan, B.; Adams, A.; Puri, A.; Di Maio, A.; Wieland, T.; Sewell, D.; Dick, K.; Wiseman, D.; Wilks, D. P.; Goodall, M.; Drayson, M. T.; Khanim, F. L.; Bunce, C.

10.1101/2023.01.02.522534 — microbiology — Posted on 2023-01-03

3888 Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses

Jossi, S. E.; Arcuri, M.; Alshayea, A.; Persaud, R. R.; Marcial-Juarez, E.; Palmieri, E.; Di Benedetto, R.; Perez-Toledo, M.; Pillaye, J.; Channell, W. M.; Schager, A. E.; Lamerton, R. E.; Cook, C. N.; Goodall, M.; Hanaeda, T.; Baumler, A. J.; Jackson-Jones, L. H.; Toellner, K.-M.; Maclennan, C.; Henderson, I. R.; Micoli, F.; Cunningham, A. F.

10.1101/2023.01.03.522561 — immunology — Posted on 2023-01-03

3889 Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

Li, Q.; Nemecz, A.; Ayme, G.; Prevost, M. S.; Pons, S.; Dejean de la Batie, G.; Barilone, N.; Baachaoui, R.; Maskos, U.; Lafaye, P.; Corringer, P.-J.

10.1101/2023.01.03.522562 — neuroscience — Posted on 2023-01-03

3890 Neural correlates of face perception modeled with a convolutional recurrent neural network

O'Reilly, J. A.; Wehrman, J.; Carey, A.; Bedwin, J.; Hourn, T.; Asadi, F.; Sowman, P. F.

10.1101/2023.01.02.522523 — neuroscience — Posted on 2023-01-03

3891 Meditation attenuates Default-mode activity: a pilot study using ultra-high strength MRI

Ganesan, S.; Moffat, B.; Van Dam, N.; Lorenzetti, V.; Zalesky, A.

10.1101/2023.01.02.522524 — neuroscience — Posted on 2023-01-03

3892 Expression profiling of the learning striatum

Lousada, E.; Kliesmete, Z.; Janjic, A.; Burguiere, E.; Enard, W.; Schreiweis, C.

10.1101/2023.01.03.522560 — neuroscience — Posted on 2023-01-03

3893 Pelage Variation and Morphometrics of Closely Related Callithrix Marmoset Species and Their Hybrids

10.1101/2023.01.01.522211 — zoology — Posted on 2023-01-03

3894 Mapping the dynamic cell surface interactome of high-density lipoprotein reveals Aminopeptidase N as modulator of its endothelial uptake

Frey, K.; Rohrer, L.; Potapenko, A.; Goetze, S.; von Eckardstein, A.; Wollscheid, B.

10.1101/2023.01.03.522574 — systems biology — Posted on 2023-01-03

3895 A simple and efficient in planta transformation method based on the active regeneration capacity of plants

Mei, G.; Chen, A.; Wang, Y.; Li, S.; Wu, M.; Liu, X.; Hou, X.

10.1101/2023.01.02.522521 — plant biology — Posted on 2023-01-03

3896 Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage and regeneration response after cisplatin

Wijaya, L. S.; Kunnen, S.; Trairatphisan, P.; Fisher, C.; Crosby, M.; Schaefer, K.; Bodie, K.; Vaughan, E.; Breidenbach, L.; Reich, T.; Clausznitzer, D.; Bonnet, S. A.; Zheng, S.; Pont, C.; Stevens, J. L.; Le Devedec, S. E.; Water, B. v. d.

10.1101/2023.01.03.522568 — pharmacology and toxicology — Posted on 2023-01-03

3897 EFNB1 level affects drug response in DLBCL cell lines

Li, X.; Zhang, C.; Deng, M.; He, Z.; Qian, H.

10.1101/2023.01.03.522579 — pharmacology and toxicology — Posted on 2023-01-03

3898 NEK1-Mediated Phosphorylation of YAP1 is key to Prostate Cancer Progression

Ghosh, I.; Khalil, I. M.; Mirza, R.; King, J.; Olatunde, D.; De Benedetti, A.

10.1101/2023.01.03.522575 — cancer biology — Posted on 2023-01-03

3899 Transcriptomics of mussel transmissible cancer MtrBTN2 reveals accumulation of multiple cancerous traits and oncogenic pathways shared among bilaterians

Burioli, E. A. V.; HAMMEL, M.; Vignal, E.; Vidal-Dupiol, J.; Mitta, G.; Thomas, F.; Bierne, N.; Destoumieux-Garzon, D.; Charriere, G. M.

10.1101/2023.01.03.522559 — cancer biology — Posted on 2023-01-03

3900 Impact of rare structural variant events in newly diagnosed multiple myeloma

Chojnacka, M.; Diamond, B. T.; Ziccheddu, B.; Rustad, E.; Maclachlan, K. H.; Papadimitriou, M.; Boyle, E. M.; Blaney, P.; Usmani, S.; Morgan, G.; Landgren, O.; Maura, F.

10.1101/2023.01.03.522573 — cancer biology — Posted on 2023-01-03

3901 Cancer Cell`s Seven Achilles Heels: Consideration for desing of anti-cancer drug combinations.

Gahramanov, V.; Vizeacoumar, F. S.; Morales, A. M.; Bonham, K.; Sakharkar, M. K.; Vizeacoumar, F. J.; Freywald, A.; Sherman, M. Y. Y.

10.1101/2023.01.02.522527 — cancer biology — Posted on 2023-01-03

3902 Modulating membrane shape and mechanics of minimal cells by light: area increase, softening and interleaflet coupling of membrane models doped with azobenzene-lipid photoswitches

Aleksanyan, M.; Grafmueller, A.; Crea, F.; Gergiev, V. N.; Heberle, J.; Dimova, R.

10.1101/2023.01.03.522478 — biophysics — Posted on 2023-01-03

3903 AimSeg: a machine-learning-aided tool for axon, inner tongue and myelin segmentation

Rondelli, A. M.; Morante-Redolat, J. M.; Bankhead, P.; Vernay, B.; Williams, A.; Carrillo-Barbera, P.

10.1101/2023.01.02.522533 — bioinformatics — Posted on 2023-01-03

3904 Computational workflow and interactive analysis of single-cell expression profiling of islets generated by the Human Pancreas Analysis Program

Patil, A.; Schug, J.; HPAP, ; Naji, A.; Kaestner, K.; Faryabi, R.; Vahedi, G.

10.1101/2023.01.03.522578 — genomics — Posted on 2023-01-03

3905 Resolving the heterogeneity of L1 DNA methylation reveals the epigenetic and transcriptional interplay between L1s and their integration sites.

Lanciano, S.; Philippe, C.; Sarkar, A.; Domrane, C.; Doucet, A. J.; van Essen, D.; Saccani, S.; Ferry, L.; Defossez, P.-A.; Cristofari, G.

10.1101/2023.01.03.522582 — genomics — Posted on 2023-01-03

3906 Systematic assessment of the contribution of structural variants to inherited retinal diseases

Wen, S.; Wang, M.; Qian, X.; Li, Y.; Wang, K.; Choi, J.; Pennesi, M. E.; Yang, P.; Marra, M.; Koenekoop, R. K.; Lopez, I.; Matynia, A.; Gorin, M.; Sui, R.; Yao, F.; Goetz, K.; Porto, F. B. O.; Chen, R.

10.1101/2023.01.02.522522 — genetics — Posted on 2023-01-03

3907 Transfer Learning with False Negative Control Improves Polygenic Risk Prediction

Jeng, X. J.; Hu, Y.; Tzeng, J.-Y.

10.1101/2023.01.02.522532 — genetics — Posted on 2023-01-03

3908 The Potential of the Primitive: a Network Analysis of Early Arthropod Evolution

Ostachuk, A.

10.1101/2023.01.03.522586 — evolutionary biology — Posted on 2023-01-03

3909 Lifestyle and not density of fish hosts determines parasite distribution over time and space

Kmentova, N.; Cruz-Laufer, A. J.; Milec, L.; Moons, T.; Heeren, S.; van den Hoorn, E.; Thys, K. J. M.; Makasa, L.; Chocha Manda, A.; Masilya Mulungula, P.; Van Steenberge, M.; Jorissen, M.; Vanhove, M. P. M.

10.1101/2023.01.03.522369 — ecology — Posted on 2023-01-03

3910 A single-cell, time-resolved profiling of Xenopus mucociliary epithelium reveals non-hierarchical model of development

Lee, J.; Moller, A. F.; Chae, S.; Bussek, A.; Kim, Y.; Lee, H.-S.; Park, T. J.; Pers, T. H.; Kwon, T.; Sedzinski, J.; Natarajan, K. N.

10.1101/2023.01.03.521555 — developmental biology — Posted on 2023-01-03

3911 In Vivo Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem Cells

Nakajima, I.; Tsukimura, T.; Ono, T.; Shiga, T.; Shitara, H.; Togawa, T.; Sakuraba, H.; Miyaoka, Y.

10.1101/2023.01.03.522057 — cell biology — Posted on 2023-01-03

3912 Pan-genome study underling the extent of genomic variation of invasive Streptococcus pneumoniae in Malawi

Iranzadeh, A.; Alisoltani, A.; Kiran, A.; Breiman, R.; Chaguza, C.; Peno, C.; French, N.; Cornick, J. E.; Everett, D. B.; Mulder, N.

10.1101/2023.01.02.522535 — microbiology — Posted on 2023-01-03

3913 The Respiratory Syncytial Virus M2-2 protein is targeted for proteasome degradation and inhibits translation and stress granules assembly

Scudero, O. B.; Santiago, V. F.; Palmisano, G.; Simabuco, F. M.; Ventura, A. M.

10.1101/2023.01.02.522538 — microbiology — Posted on 2023-01-03

3914 Chronic social stress blunts core body temperature and molecular rhythms of Cirbp and Rbm3 in mice lateral habenula

Haniffa, S.; Narain, P.; Hughes, M.; Petkovic, A.; Susic, M.; Mlambo, V.; Chaudhury, D.

10.1101/2023.01.02.522528 — neuroscience — Posted on 2023-01-03

3915 Pore-like diffusion barriers in murine cardiac myocytes

Deisl, C.; Chung, J.; Hilgemann, D. W.

10.1101/2023.01.02.522313 — physiology — Posted on 2023-01-03

3916 MASH Native: A Unified Solution for Native Top-Down Proteomics Data Processing

10.1101/2023.01.02.522513 — bioinformatics — Posted on 2023-01-03

3917 A quantitative theory for genomic offset statistics

Gain, C.; Rhone, B.; CUBRY, P.; Salazar, I.; Forbes, F.; Vigouroux, y.; Jay, F.; Francois, O.

10.1101/2023.01.02.522469 — evolutionary biology — Posted on 2023-01-03

3918 The evolution and spread of sulfur-cycling enzymes reflect the redox state of the early Earth

Mateos, K.; Chappell, G.; Klos, A.; Le, B.; Stueeken, E. E.; Anderson, R. E.

10.1101/2022.08.05.502933 — evolutionary biology — Posted on 2023-01-03

3919 LoxCode in vivo clonal barcoding resolves mammalian epiblast contribution to fetal organs

Naik, S.; Weber, T. S.; Biben, C.; Tam, P.; Zhang, S.; Miles, D. C.; Taoudi, S.

10.1101/2023.01.02.522501 — developmental biology — Posted on 2023-01-03

3920 The Embryonic Origin of Primordial Germ Cells in the Tardigrade Hypsibius exemplaris

Heikes, K. L.; Game, M.; Smith, F. W.; Goldstein, B.

10.1101/2023.01.02.522500 — developmental biology — Posted on 2023-01-03

3921 Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis

Dave, B. M.; Chen, X.; McCready, F.; Tailor, J. K.; Ellis, J.; Huang, X.; Dirks, P. B.

10.1101/2023.01.02.522503 — developmental biology — Posted on 2023-01-03

3922 Cognition's dependence on functional network integrity with age is conditional on structural network integrity

Liu, X.; Tyler, L. K.; Cam-CAN, ; Davis, S. W.; Rowe, J.; Tsvetanov, K. A.

10.1101/2023.01.02.522493 — neuroscience — Posted on 2023-01-03

3923 An isogenic human iPSC model unravels neurodevelopmental abnormalities in SMA

Grass, T.; Rosignol, I.; Thomas, J.; Buchner, F.; Dokuzluoglu, Z.; Dalinskaya, A.; Becker, J.; Wirth, B.; Rodriguez-Muela, N.

10.1101/2023.01.02.522499 — neuroscience — Posted on 2023-01-03

3924 How honey bees make fast and accurate decisions

MaBouDi, H.; Marshall, J. A. R.; Dearden, N.; Barron, A. B.

10.1101/2023.01.02.522517 — neuroscience — Posted on 2023-01-03

3925 Circuit to target approach defines an autocrine myofibroblast loop that drives cardiac fibrosis

Miyara, S.; Adler, M.; Bassat, E.; Divinsky, Y.; Umansky, K. B.; Elkahal, J.; Genzelinakh, A.; Kain, D.; Lendengolts, D.; Shalit, T.; Gershovits, M.; Shakked, A.; Zhang, L.; Wang, J.; Kimchi, D. M.; Baehr, A.; Sarig, R.; Kupatt, C.; Tanaka, E. M.; Medzhitov, R.; Mayo, A.; Alon, U.; Tzahor, E.

10.1101/2023.01.01.522422 — systems biology — Posted on 2023-01-03

3926 Engineering and characterization of carbohydrate-binding modules to enable real-time imaging of cellulose fibrils biosynthesis in plant protoplasts

Jayachandran, D.; Smith, P.; Irfan, M.; Sun, J.; Yarborough, J. M.; Bomble, Y. J.; Lam, E.; Chundawat, S. P. S.

10.1101/2023.01.02.522519 — plant biology — Posted on 2023-01-03

3927 Ethyl Maltol Disrupts Iron Homeostasis in SH-SY5Y Neuroblastoma Cell Line

Sun, Y.; Bressler, J. P.

10.1101/2023.01.02.522514 — pharmacology and toxicology — Posted on 2023-01-03

3928 EZH2 mutations in follicular lymphoma distort H3K27me3 profiles and alter transcriptional responses to PRC2 inhibition

Romero, P.; Richart, L.; Aflaki, S.; Burton, M.; Michaud, A.; Masliah-Planchon, J.; Kuhnoswki, F.; Meaudre, C.; Luscan, A.; Hamza, A.; Legoix, P.; Vincent-Salomon, A.; Wassef, M.; Holoch, D.; Margueron, R.

10.1101/2023.01.02.522460 — cancer biology — Posted on 2023-01-03

3929 DISCO+QR: Rooting Species Trees in the Presence of GDL and ILS

Willson, J.; Tabatabaee, Y.; Liu, B.; Warnow, T.

10.1101/2023.01.02.522492 — bioinformatics — Posted on 2023-01-03

3930 RNA-seq preprocessing and sample size considerations for gene network inference

Altay, G.; Zapardiel-Gonzalo, J.; Peters, B.

10.1101/2023.01.02.522518 — bioinformatics — Posted on 2023-01-03

3931 Molecular characterization of nervous system organization in the hemichordate Saccoglossus kowalevskii

Andrade Lopez, J. M.; Pani, A. M.; Wu, M.; Gerhart, J.; Lowe, C. J.

10.1101/2023.01.02.522090 — evolutionary biology — Posted on 2023-01-03

3932 Genome-wide temperature-sensitivity of PcG regulation and reduction thereof in temperate Drosophila melanogaster

Voigt, S.; Froschauer, C.

10.1101/2023.01.02.522482 — evolutionary biology — Posted on 2023-01-03

3933 Defining Cardiac Nerve Architecture During Development, Disease, and Regeneration

Salamon, R. J.; Halbe, P.; Kasberg, W.; Bae, J.; Audhya, A.; Mahmoud, A. I.

10.1101/2022.12.31.522405 — developmental biology — Posted on 2023-01-03

3934 Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

Wang, J.; Cheng, M.; Gao, M.; Sun, Y.; Lu, Y.; Li, X.; Shi, C.; Wang, J.; Wang, N.; Yang, W.; Jiang, Y.; Huang, H.; Yang, G.; Zeng, Y.; Wang, C.; Cao, X.

10.1101/2023.01.01.522424 — immunology — Posted on 2023-01-03

3935 A surprising lack of presaccadic benefits during visual change detection

Gupta, P.; Sridharan, D.

10.1101/2023.01.01.522284 — neuroscience — Posted on 2023-01-03

3936 Optimizing FreeSurfer's Surface Reconstruction Parameters for Anatomical Feature Estimation

Baratz, Z.; Assaf, Y.

10.1101/2023.01.02.522457 — neuroscience — Posted on 2023-01-03

3937 The statistics of natural shapes predict high-level aftereffects in human vision

Morgenstern, Y.; Storrs, K. R.; Schmidt, F.; Hartmann, F.; Tiedemann, H.; Wagemans, J.; Fleming, R.

10.1101/2023.01.02.522484 — neuroscience — Posted on 2023-01-03

3938 Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation

Vinje, V.; Zapf, B.; Ringstad, G.; Eide, P. K.; Rognes, M. E.; Mardal, K.

10.1101/2023.01.01.522190 — neuroscience — Posted on 2023-01-03

3939 Multiple independent components contribute to event-related potential correlates of conscious vision

Colombari, E.; Railo, H.

10.1101/2023.01.02.522455 — neuroscience — Posted on 2023-01-03

3940 Modulation of Giant Depolarizing Potentials (GDPs) in Human Large Basket Cells by Norepinephrine and Acetylcholine

Yang, D.; Qi, G.; Ort, J.; Witzig, V.; Bak, A.; Delev, D.; Koch, H.; Feldmeyer, D.

10.1101/2023.01.02.522475 — neuroscience — Posted on 2023-01-03

3941 Facial representation comparisons between human brain and deep convolutional neural network reveal a fatigue repetition suppression mechanism

Lu, Z.; Ku, Y.

10.1101/2023.01.02.522298 — neuroscience — Posted on 2023-01-03

3942 Rice potassium transporter OsHAK18 mediates phloem K+ loading and redistribution

Shen, L.; Wu, Q.; Fan, W.; Luan, J.; Li, N.; Chen, D.; Tian, Q.; Jing, W.; Zhang, W.

10.1101/2023.01.02.522451 — plant biology — Posted on 2023-01-03

3943 Genomic relationships among diploid and polyploid species of the genus Ludwigia L. section Jussiaea using a combination of cytogenetic, morphological, and crossing investigations

BARLOY, D.; Portillo-Lemus, L.; Krueger-Hadfield, S.; Huteau, V.; Coriton, O.

10.1101/2023.01.02.522458 — plant biology — Posted on 2023-01-03

3944 E3 Ubiquitin Ligase CHIP Drives Monoubiquitination-mediated Nuclear Import of Tumor Suppressor PTEN

Chakraborty, S.; Karmakar, S.; Basu, M.; Ghosh, M. K.

10.1101/2023.01.02.522453 — cancer biology — Posted on 2023-01-03

3945 The Labbing Project: A database management application for neuroimaging research

Baratz, Z.; Assaf, Y.

10.1101/2023.01.02.522426 — bioinformatics — Posted on 2023-01-03

3946 Scribe: next-generation library searching for DDA experiments

Searle, B. C.; Shannon, A. E.; Wilburn, D. B.

10.1101/2023.01.01.522445 — bioinformatics — Posted on 2023-01-03

3947 Estimation of the expectation of species richness difference of two-subcommunities from site-suitability difference in a species-independent stochastic model

Iritani, R.

10.1101/2023.01.01.522407 — ecology — Posted on 2023-01-03

3948 Real time mobilization of a novel diatom Mutator-Like Element (MULE) transposon to inactivate the uridine monophosphate synthase (UMPS) locus in Phaeodactylum tricornutum

Abbriano, R. M.; George, J.; Kahlke, T.; Commault, A. S.; Fabris, M.

10.1101/2023.01.02.522487 — molecular biology — Posted on 2023-01-03

3949 CircPLXNA2 affects the proliferation and apoptosis of myoblast through circPLXNA2/gga-miR-12207-5P/MDM4 axis

Dong, X.; Xing, J.; Liu, Q.; Ye, M.; Zhou, Z.; Li, Y.; Li, Z.; Nie, Q.

10.1101/2023.01.01.522409 — molecular biology — Posted on 2023-01-03

3950 LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry.

Yang, Y.; Chen, H.; Corey, R.; Morales, V.; Quentin, Y.; Froment, C.; Caumont-Sarcos, A.; Albenne, C.; Burlet-Schiltz, O.; Ranava, D.; Stansfeld, P. J.; Marcoux, J.; Ieva, R.

10.1101/2023.01.02.522452 — microbiology — Posted on 2023-01-03

3951 The predictive power of intrinsic timescale during the perceptual decision-making process across the mouse brain

Imani, E.; Hashemi, A.; Radkani, S.; Egger, S. W.; Moazami Goudarzi, M.

10.1101/2023.01.01.522410 — neuroscience — Posted on 2023-01-03

3952 Temperature-Sensitive Contact Modes Allosterically Gate TRPV3

Burns, D.; Venditti, V.; Potoyan, D. A.

10.1101/2023.01.02.522497 — biophysics — Posted on 2023-01-03

3953 RNAP promoter search and transcription kinetics in live E. coli cells

Bettridge, K. E.; Harris, F.; Yeyha, N.; Xiao, J.

10.1101/2022.12.31.522404 — biophysics — Posted on 2023-01-03

3954 Structure of the ISW1a complex bound to the dinucleosome

Li, L.; Chen, K.; Sia, Y.; Hu, P.; Ye, Y.; Chen, Z.

10.1101/2023.01.02.522444 — biochemistry — Posted on 2023-01-03

3955 Clarifying the biological and statistical assumptions of cross-sectional biological age predictors

Sluiskes, M. H.; Goeman, J. J.; Beekman, M.; Slagboom, P. E.; Putter, H.; Rodriguez-Girondo, M.

10.1101/2023.01.01.522413 — molecular biology — Posted on 2023-01-03

3956 Gre factors protect against phenotypic diversification and cheating in Escherichia coli populations under toxic metabolite stress

Sivaloganathan, D. M.; Brynildsen, M. P.

10.1101/2023.01.02.522506 — microbiology — Posted on 2023-01-03

3957 Prediction of Polygenic Risk Score by Machine Learning and Deep Learning Methods in Genome-wide Association Studies

Öztornaci, R. O.; Cosgun, E.; Colak, C.; Tasdelen, B.

10.1101/2022.12.30.522280 — bioinformatics — Posted on 2023-01-03

3958 Genetic architectures of postmating isolation and morphology of two highly diverged rockfishes (genus Sebastes)

Muto, N.; Kawasaki, T.; Kakioka, R.; Nagano, A. J.; Shimizu, Y.; Inose, S.; Shimizu, Y.; Takahashi, H.

10.1101/2022.05.27.493803 — evolutionary biology — Posted on 2023-01-03

3959 The search behavior of terrestrial mammals

Noonan, M. J.; Martinez-Garcia, R.; Fleming, C. H.; Garcia De Figueiredo, B.; Ali, A. H.; Attias, N.; Belant, J. L.; Beyer, D. E.; Berteaux, D.; Bidner, L. R.; Boone, R. B.; Boutin, S.; Brito, J.; Brown, M.; Carter, A.; Castellanos, A.; Castellanos, F. X.; Chitwood, M. C.; Darlington, S.; de la Torre, J. A.; Dekker, J.; DePerno, C.; Droghini, A.; Farhadinia, M.; Fennessy, J.; Fichtel, C.; Ford, A. T.; Gill, R.; Goheen, J.; Gustavo R. Oliveira-Santos, L.; Hebblewhite, M.; Hodges, K. E.; Isbell, L. A.; Janssen, R.; Kappeler, P. M.; Kays, R.; Kaczensky, P.; Kauffman, M.; LaPoint, S.; Lashley, M.;

10.1101/2022.12.31.521874 — ecology — Posted on 2023-01-03

3960 SNARE protein tomosyn regulates dense core vesicle composition but not exocytosis in mammalian neurons

Subkhangulova, A.; Gonzalez-Lozano, M. A.; Groffen, A. J. A.; van Weering, J. R. T.; Smit, A. B.; Toonen, R. F.; Verhage, M.

10.1101/2022.12.18.520925 — neuroscience — Posted on 2023-01-03

3961 A quantitative, genome-wide analysis in Drosophila reveals transposable elements' influence on gene expression is species-specific

Fablet, M.; Salces-Ortiz, J.; Jacquet, A.; Menezes, B. F.; Dechaud, C.; Veber, P.; Nous, C.; Rebollo, R.; Vieira, C.

10.1101/2022.01.20.477049 — genomics — Posted on 2023-01-03

3962 Deleterious effects of thermal and water stresses on life history and physiology: a case study on woodlouse

DEPEUX, C.; BRANGER, A.; MOULIGNIER, T.; MOREAU, J.; Lemaitre, J.-F.; DECHAUME-MONCHARMONT, F.-X.; LAVERRE, T.; PAULHAC, H.; GAILLARD, J.-M.; BELTRAN-BECH, S.

10.1101/2022.09.26.509512 — evolutionary biology — Posted on 2023-01-03

3963 Combining Aperiodic 1/f Slopes and Brain Simulation: An EEG/MEG Proxy Marker of Excitation/Inhibition Imbalance in Alzheimer's Disease

Martinez-Canada, P.; Perez-Valero, E.; Minguillon, J.; Pelayo, F.; Lopez-Gordo, M. A.; Morillas, C. A.

10.1101/2022.12.21.521529 — neuroscience — Posted on 2023-01-03

3964 Approximating carbon fixation - how important is the Calvin-Benson cycle steady-state assumption?

van Aalst, M.; Ebenhoeh, O.; Walker, B. J.

10.1101/2022.11.18.517021 — plant biology — Posted on 2023-01-03

3965 Glucagon-Like Peptide-1 Receptor Activation Stimulates PKA-Mediated Phosphorylation of Raptor and this Contributes to the Weight Loss Effects of Liraglutide

Le, T. D. V.; Liu, D.; Ellis, B. J.; Collins, S.; Ayala, J. E.

10.1101/2022.04.21.489078 — physiology — Posted on 2023-01-03

3966 Near-critical tuning of cooperativity revealed by spontaneous switching in a protein signalling array

Keegstra, J. M.; Avgidis, F.; Mulla, Y.; Parkinson, J. S.; Shimizu, T. S.

10.1101/2022.12.04.518992 — biophysics — Posted on 2023-01-03

3967 Multiomic Analysis of Adult Diapause in Drosophila melanogaster Identifies Hallmarks of Cellular Quiescence

Hutfilz, C.

10.1101/2022.12.21.521440 — genomics — Posted on 2023-01-03

3968 Microbial symbionts are shared between ants and their associated beetles

Valdivia, C.; Newton, J. A.; O'Donnell, S.; von Beeren, C.; Kronauer, D. J. C.; Russell, J. A.; Lukasik, P.

10.1101/2022.12.02.518891 — ecology — Posted on 2023-01-03

3969 Rac negative feedback links local PIP3 rate-of-change to dynamic control of neutrophil guidance

Town, J. P.; Weiner, O. D.

10.1101/2022.12.30.521706 — cell biology — Posted on 2023-01-03

3970 Tissue-resident memory T cells mediate mucosal immunity to recurrent urinary tract infection

Rousseau, M.; Lacerda Mariano, L.; Canton, T.; Ingersoll, M. A.

10.1101/2021.10.28.466224 — immunology — Posted on 2023-01-03

3971 Uncovering the Organization of Neural Circuits with Generalized Phase Locking Analysis

Safavi, S.; Panagiotaropoulos, T. I.; Kapoor, V.; Ramirez-Villegas, J. F.; Logothetis, N. K.; Besserve, M.

10.1101/2020.12.09.413401 — neuroscience — Posted on 2023-01-03

3972 Distinct cellular origins and differentiation process account for distinct oncogenic and clinical behaviors of leiomyosarcomas

Darbo, E.; Perot, G.; Darmusey, L.; Le Guellec, S.; Leroy, L.; Gaston, L.; Desplat, N.; Thebault, N.; Merle, C.; Rochaix, P.; Valentin, T.; Ferron, G.; Chevreau, C.; Bui, B.; Stoeckle, E.; Ranchere-Vince, D.; Meeus, P.; Terrier, P.; Piperno-Neumann, S.; Collin, F.; De Pinieux, G.; Duffaud, F.; Coindre, J.-M.; Blay, J.-Y.; Chibon, F.

10.1101/2020.10.23.352336 — cancer biology — Posted on 2023-01-03

3973 Increased intracellular crowding during hyperosmotic stress

Kitamura, A.; Oasa, S.; Kawaguchi, H.; Osaka, M.; Vukojevic, V.; Kinjo, M.

10.1101/2022.12.30.522363 — biophysics — Posted on 2023-01-03

3974 Entropy predicts sensitivity of pseudo-random seeds

Maier, B. D.; Sahlin, K.

10.1101/2022.10.13.512198 — bioinformatics — Posted on 2023-01-03

3975 UNCURL-App: Interactive Database-Driven Analysis of Single Cell RNA Sequencing Data

Zhang, Y.; Mao, S.; Mukherjee, S.; Kannan, S.; Seelig, G.

10.1101/2020.04.15.043737 — bioinformatics — Posted on 2023-01-03

3976 De novo design of site-specific protein interactions with learned surface fingerprints

Gainza, P.; Wehrle, S.; Van Hall-Beauvais, A.; Marchand, A.; Scheck, A.; Harteveld, Z.; Ni, D.; Tan, S.; Sverrisson, F.; Goverde, C.; Turelli, P.; Raclot, C.; Teslenko, A.; Pacesa, M.; Rosset, S.; Buckley, S.; Georgeon, S.; Marsden, J.; Petruzzella, A.; Liu, K.; Xu, Z.; Chai, Y.; Han, P.; Gao, G. F.; Oricchio, E.; Fierz, B.; Trono, D.; Stahlberg, H.; Bronstein, M.; Correia, B. E.

10.1101/2022.06.16.496402 — bioengineering — Posted on 2023-01-03

3977 Degenerative changes are associated with severity of anterior cruciate ligament injury within the skeletally immature joint

Howe, D.; Thompson, J. D.; Teeter, S. D.; Barlow, O.; Griffith, E. H.; Schnabel, L. V.; Spang, J. T.; Fisher, M. B.

10.1101/2022.11.12.516262 — bioengineering — Posted on 2023-01-03

3978 TREE-QMC: Improving quartet graph construction for scalable and accurate species tree estimation from gene trees

Han, Y.; Molloy, E.

10.1101/2022.06.25.497608 — evolutionary biology — Posted on 2023-01-03

3979 Signaling protein abundance modulates the strength of the Spindle Assembly Checkpoint

Chen, C.; Humphrey, L.; Jema, S.; Karmarkar, S.; Ferrari, F.; Joglekar, A.

10.1101/2022.05.10.491369 — cell biology — Posted on 2023-01-03

3980 Grasping with a twist: Dissociating action goals from motor actions in human frontoparietal circuits

Rens, G.; Figley, T. D.; Gallivan, J. P.; Liu, Y.; Culham, J.

10.1101/2023.01.02.522486 — neuroscience — Posted on 2023-01-02

3981 Auditory and Reward Connectivity in Young and Older Adults During Music Listening and Rest

Belden, A.; Quinci, M. A.; Geddes, M. R.; Hanser, S. B.; Donovan, N. J.; Loui, P.

10.1101/2023.01.01.522417 — neuroscience — Posted on 2023-01-02

3982 Neural Synchronization as a Function of Engagement with the Narrative

Ohad, T.; Yeshurun, Y.

10.1101/2023.01.01.522416 — neuroscience — Posted on 2023-01-02

3983 Learning Cortical Hierarchies with Temporal Hebbian Updates.

Aceituno, P. V.; Farinha, M. T.; Loidl, R.; Grewe, B. F.

10.1101/2023.01.02.522459 — neuroscience — Posted on 2023-01-02

3984 Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson's patients

Lofredi, R.; Okudzhava, L.; Irmen, F.; Bruecke, C.; Huebl, J.; Krauss, J. K.; Schneider, G.-H.; Faust, K.; Neumann, W.-J.; Kuehn, A. A.

10.1101/2022.05.06.490913 — neuroscience — Posted on 2023-01-02

3985 MitoMouse is a model reconstruction of murine mitochondrial metabolism

Chapman, S.; Molinie, T.; Mourier, A.; Habermann, B. H.

10.1101/2023.01.02.522468 — systems biology — Posted on 2023-01-02

3986 An empirical assay of view-invariant object learning in humans and comparison with baseline image-computable models

Lee, M. J.; DiCarlo, J. J.

10.1101/2022.12.31.522402 — animal behavior and cognition — Posted on 2023-01-02

3987 Endoparasitoid lifestyle promotes endogenization and domestication of dsDNA viruses

Guinet, B.; Lepetit, D.; Charlat, S.; Buhl, P. N.; Notton, D. G.; Cruaud, A.; Rasplus, J.-Y.; Stigenberg, J.; de Vienne, D. M.; Boussau, B.; Varaldi, J.

10.1101/2022.11.16.515002 — genomics — Posted on 2023-01-02

3988 DUAL FUNCTION OF ZIKA VIRUS NS2B-NS3 PROTEASE

Shiryaev, S.; Cieplak, P.; Cheltsov, A.; Liddington, R. C.; Terskikh, A.

10.1101/2021.11.28.470275 — immunology — Posted on 2023-01-02

3989 High bacillary burden and the ESX-1 type VII secretion system promote MHC class I presentation by Mycobacterium tuberculosis infected macrophages to CD8 T-cells

Mott, D.; Yang, J.; Baer, C.; Papavinasasundaram, K.; Sassetti, C. M.; Behar, S. M.

10.1101/2022.10.20.513087 — immunology — Posted on 2023-01-02

3990 Enhanced Sodium Channel Inactivation by Temperature and FHF2 Deficiency Blocks Heat Nociception

Marra, C.; Hartke, T.; Ringkamp, M.; Goldfarb, M.

10.1101/2022.02.12.480202 — neuroscience — Posted on 2023-01-02

3991 A sleep-active neuron can promote survival while sleep behavior is disturbed

Busack, I.; Bringmann, H.

10.1101/2022.04.03.486914 — neuroscience — Posted on 2023-01-02

3992 Effects of sensorineural hearing loss on formant-frequency discrimination: Measurements and models

Carney, L. H.; Cameron, D. A.; Kinast, K. B.; Feld, C. E.; Schwarz, D. M.; Leong, U.-C.; McDonough, J. M.

10.1101/2022.10.26.513920 — neuroscience — Posted on 2023-01-02

3993 Neurological Disorder after Severe Pneumonia is Associated with Translocation of Bacteria from Lung to Brain

Ma, Q.; Yao, C.; Wu, Y.; Wang, H.; Fan, Q.; Yang, Q.; Xu, J.; Dai, H.; Zhang, Y.; Xu, F.; Lu, T.; Wang, C.

10.1101/2022.12.30.522351 — neuroscience — Posted on 2023-01-02

3994 Both GEF domains of the autism and epilepsy-associated Trio protein are required for proper tangential migration of GABAergic interneurons

Eid, L.; Lokmane, L.; Raju, P. K.; Tene Tadoum, S. B.; Jiang, X.; Toulouse, K.; Lupien-Meilleur, A.; Charron-Ligez, F.; Toumi, A.; Backer, S.; Lachance, M.; Lavertu-Jolin, M.; Montseny, M.; Lacaille, J.-C.; Bloch-Gallego, E.; Rossignol, E.

10.1101/2022.12.31.522400 — neuroscience — Posted on 2023-01-02

3995 Incorporating models of subcortical processing improves the ability to predict EEG responses to natural speech

Lindboom, E.; Nidiffer, A.; Carney, L. H.; Lalor, E. C.

10.1101/2023.01.02.522438 — neuroscience — Posted on 2023-01-02

3996 Robust total X-ray scattering workflow to study correlated motion of proteins in crystals

Meisburger, S. P.; Case, D. A.; Ando, N.

10.1101/2022.08.22.504832 — biophysics — Posted on 2023-01-02

3997 EquiFold: Protein Structure Prediction with a Novel Coarse-Grained Structure Representation

Lee, J. H.; Yadollahpour, P.; Watkins, A.; Frey, N. C.; Leaver-Fay, A.; Ra, S.; Cho, K.; Gligorijevic, V.; Regev, A.; Bonneau, R.

10.1101/2022.10.07.511322 — bioinformatics — Posted on 2023-01-02

3998 Neuron types in the developing mouse CNS can be divided into several epigenomic and transcriptomic classes

Kilpinen, S.; Heliola, H.; Achim, K.

10.1101/2022.12.29.522188 — genomics — Posted on 2023-01-02

3999 Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain

Wu, Y.; Walker, J.; Ning, L.; Westberg, M.; Monje, M.; Kirkland, T.; Lin, M.; Su, Y.

10.1101/2022.12.30.522361 — pharmacology and toxicology — Posted on 2023-01-02

4000 Carcinogen induced expansion of atypical B cells and pre-treatment tumor adjacent tertiary lymphoid structures associate with poor response to BCG in non-muscle invasive bladder cancer

Yolmo, P.; Rahimi, S.; Chenard, S.; Conseil, G.; Jenkins, D.; Emon, I.; Hamilton, J.; Xu, M.; Rangachari, M.; Berman, D. M.; Siemens, D. R.; Koti, M.

10.1101/2022.12.30.522127 — cancer biology — Posted on 2023-01-02

4001 High Sensitivity Top-down Proteomics Captures Single Muscle Cell Heterogeneity in Large Proteoforms

Melby, J. A.; Brown, K. A.; Gregorich, Z. R.; Roberts, D. S.; Chapman, E. A.; Ehlers, L. E.; Gao, Z.; Larson, E. J.; Jin, Y.; Lopez, J.; Hartung, J.; Zhu, Y.; Wang, D.; Guo, W.; Diffee, G. M.; Ge, Y.

10.1101/2022.12.29.521273 — biochemistry — Posted on 2023-01-02

4002 Revealing the function of HMGB1 N-terminal acetylation by a protein semi-synthesis approach

Wei, T.; Liu, J.; Tan, Y.; Li, C.; Wei, R.; Wang, J.; Wu, H.; Li, Q.; Liu, H.; Tang, Y.; Li, X.

10.1101/2021.10.05.463167 — biochemistry — Posted on 2023-01-02

4003 Transcriptional patterns of sexual dimorphism and in host developmental programs in the model parasitic nematode Heligmosomoides bakeri

Pollo, S. M. J.; Coria, A. L.; Liu, H.; Cruces Gonzalez, D.; Finney, C. A. M.; Wasmuth, J. D.

10.1101/2022.09.14.508015 — genomics — Posted on 2023-01-02

4004 Jaccard dissimilarity in stochastic community models based on the species-independence assumption

Iritani, R.; Ontiveros, V. L. J.; Alonso, D.; Capitan, J. A.; Godsoe, W.; Tatsumi, S.

10.1101/2022.12.13.520233 — ecology — Posted on 2023-01-02

4005 Evidence for a functional interaction between the respiratory syncytial virus fusion and attachment proteins in the envelope of infectious virus particles.

Sugrue, R.; Tan, B. H.; Huong, T. N.

10.1101/2022.12.18.520517 — microbiology — Posted on 2023-01-02

4006 Persistent increase in human-caused wolf mortality following the 2012-2014 Minnesota hunting seasons

Oliynyk, R. T.

10.1101/2022.12.20.521126 — zoology — Posted on 2023-01-02

4007 Damage dynamics in single E. coli and the role of chance in the timing of cell death

Yang, Y.; Karin, O.; Mayo, A.; Song, X.; Chen, P.; Santos, A. L.; Lindner, A. B.; Alon, U.

10.1101/2022.10.17.512406 — systems biology — Posted on 2023-01-02

4008 Phylogenetic analyses of AGO/DCL/RDR proteins in green plants refine the evolution of small RNA pathways

Belanger, S.; Zhan, J.; Meyers, B. C.

10.1101/2022.01.18.476847 — plant biology — Posted on 2023-01-02

4009 Reduced blood to brain glucose transport as the cause for hyperglycemia: a model that resolves multiple anomalies in type 2 diabetes

Ojha, A.; Watve, M.

10.1101/2022.01.19.477014 — physiology — Posted on 2023-01-02

4010 EVMP: Enhancing machine learning models for synthetic promoter strength prediction by Extended Vision Mutant Priority framework

Yang, W.; Li, D.; Huang, R.

10.1101/2022.10.15.512354 — bioinformatics — Posted on 2023-01-02

4011 Using Mesoscopic Tract-Tracing Data to Guide the Estimation of Fiber Orientation Distributions in the Mouse Brain from Diffusion MRI

Liang, Z.; Arefin, T. M.; Lee, C. H.; Zhang, J.

10.1101/2022.06.02.492838 — bioengineering — Posted on 2023-01-02

4012 Mathematical characterization of fractal river networks

Terui, A.

10.1101/2022.11.07.515375 — ecology — Posted on 2023-01-02

4013 Examining the Reproductive Success of Bull Kelp (Nereocystis luetkeana) In Climate Change Conditions

Korabik, A. R.; Winquist, T.; Grosholz, E. D.; Hollarsmith, J. A.

10.1101/2022.11.01.514766 — ecology — Posted on 2023-01-02

4014 The shh limb enhancer is activated in patterned limb regeneration but not in hypomorphic limb regeneration in Xenopus laevis

Tada, R.; Higashidate, T.; Amano, T.; Ishikawa, S.; Yokoyama, C.; Nara, S.; Ishida, K.; Kawaguchi, A.; Ochi, H.; Ogino, H.; Yakushiji-Kaminatsui, N.; Sakamoto, J.; Kamei, Y.; Tamura, K.; Yokoyama, H.

10.1101/2022.12.27.522067 — developmental biology — Posted on 2023-01-02

4015 A dark matter in sake brewing: Origin of microbes producing a Kimoto-style fermentation starter

Ito, K.; Niwa, R.; Kobayashi, K.; Nakagawa, T.; Hoshino, G.; Tsuchida, Y.

10.1101/2022.11.28.518188 — microbiology — Posted on 2023-01-02

4016 Inter-individual deep image reconstruction

Ho, J. K.; Horikawa, T.; Majima, K.; Kamitani, Y.

10.1101/2021.12.31.474501 — neuroscience — Posted on 2023-01-02

4017 Generating New Musical Preferences from Multi-level Mapping of Predictions to Reward

Kathios, N.; Sachs, M. E.; Zhang, E.; Ou, Y.; Loui, P.

10.1101/2022.06.17.496615 — neuroscience — Posted on 2023-01-02

4018 Development of a 3D bioprinted airway smooth muscle model for manipulating structure and measuring contraction

Osagie, J. O.; Syeda, S. S.; Turner-Brannen, E.; Guimond, M.; Parrenas, L. C.; Haroon, A.; Imasuen, P.; West, A. R.

10.1101/2022.12.15.520464 — physiology — Posted on 2023-01-02

4019 Assessment of structural behaviour of new L-asparaginase and SAXS data-based evidence for catalytic activity in its monomeric form

Mihooliya, K. N.; Nandal, J.; Kalidas, N.; Ashish, ; Chand, S.; Verma, D. K.; Bhattaharyya, M. S.; Sahoo, D. K.

10.1101/2023.01.01.522448 — biochemistry — Posted on 2023-01-02

4020 ACE2 Receptor Decoy is a Potent Prophylactic and Therapeutic for SARS-CoV-2

Tada, T.; Dcosta, B. M.; Zhou, H.; Landau, N. R.

10.1101/2022.12.31.522401 — microbiology — Posted on 2023-01-02

4021 Botrytis cinerea small RNAs are associated with tomato AGO1 and silence tomato target genes supporting cross-kingdom RNAi between the fungal pathogen B. cinerea and its tomato host

He, B.; Cai, Q.; Weiberg, A.; Chen, A.-P.; Ouyang, S.; Borkovich, K.; Stajich, J.; Abreu-Goodger, C.; Jin, H.

10.1101/2022.12.30.522274 — plant biology — Posted on 2023-01-02

4022 Lung lipid deposition in pneumonias of viral and non-viral aetiology

Potashnikova, D. M.; Tvorogova, A. V.; Saidova, A. A.; Sotnikova, T. N.; Arifulin, E. A.; Lipina, T. V.; Shirokova, O. M.; Melnikov, E. S.; Rodina, T. A.; Valyaeva, A. A.; Zharikova, A. A.; Zayratyants, G. O.; Zayratyants, O. V.; Sheval, E. V.; Margolis, L. B.; Vasilieva, E. Y.

10.1101/2022.12.30.522299 — pathology — Posted on 2023-01-02

4023 Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

Raina, K.; Forbes, C. D.; Stronk, R.; Rappi, J. P.; Eastman, K. J.; Gerritz, S. W.; Yu, X.; Li, H.; Bhardwaj, A.; Forgione, M.; Hundt, A.; King, M. P.; Posner, Z. M.; Denny, A.; McGovern, A.; Puleo, D. E.; Garvin, E.; Chenard, R.; Zaware, N.; Mousseau, I. J.; Macaluso, J.; Martin, M.; Bassoli, K.; Jones, K.; Garcia, M.; Howard, K.; Smith, L. M.; Chen, J. M.; De Leon, C. A.; Hines, J.; Kayser-Bricker, K. J.; Crews, C. M.

10.1101/2023.01.01.522436 — cancer biology — Posted on 2023-01-02

4024 Femtomolar-level PCR-free quantification of microRNA cancer biomarkers in serum

Kanavarioti, A.

10.1101/2022.12.30.522268 — biophysics — Posted on 2023-01-02

4025 Structural insights into ubiquitin chain cleavage by Legionella ovarian tumor deubiquitinases

Kang, S.; Kim, G.; Choi, M.; Jeong, M.; Noort, G. J. v. d. H. v.; Roh, S.-H.; Shin, D.

10.1101/2023.01.02.522462 — biochemistry — Posted on 2023-01-02

4026 Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85beta/AP-2-mediated endocytosis

Matsubayashi, H. T.; Mountain, J.; Yao, T.; Peterson, A. F.; Deb Roy, A.; Inoue, T.

10.1101/2022.12.31.522383 — cell biology — Posted on 2023-01-02

4027 The bacterial genetic determinants of Escherichia coli capacity to cause bloodstream infections in humans

Burgaya, J.; Marin, J.; Royer, G.; Condamine, B.; Gachet, B.; Clermont, O.; Jaureguy, F.; Burdet, C.; Lefort, A.; de Lastours, V.; Denamur, E.; Galardini, M.; Blanquart, F.; The Colibafi/Septicoli Group, ; The COLIVILLE Group,

10.1101/2022.12.31.522367 — microbiology — Posted on 2023-01-02

4028 Novel emm4 lineage associated with an upsurge in invasive group A streptococcal disease in the Netherlands, 2022

van der Putten, B. C.; Bril-Keijzers, W. C.; Rumke, L. W.; Vestjens, S. M. T.; Koster, L. A.; Willemsen, M.; Vlaminckx, B. J. M.; de Gier, B.; van Sorge, N. M.

10.1101/2022.12.31.522331 — microbiology — Posted on 2023-01-02

4029 Massive solubility changes of neuronal proteins upon simulated traumatic brain injury reveal the role of shockwave in irreversible damage

Saei, A. A.; Gharibi, H.; Lyu, H.; Nilsson, B.; Jafari, M.; von Holst, H.; Zubarev, R. A.

10.1101/2022.12.31.522370 — neuroscience — Posted on 2023-01-02

4030 Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure

altounian, m.; bellon, a.; Mann, F.

10.1101/2022.12.30.522325 — neuroscience — Posted on 2023-01-02

4031 The formation of brain shape in human newborns

Krohn, S.; von Schwanenflug, N.; Romanello, A.; Valk, S. L.; Madan, C. R.; Finke, C.

10.1101/2023.01.01.521756 — neuroscience — Posted on 2023-01-02

4032 Evaluating the neural underpinnings of motivation for walking exercise

Doren, S.; Schwab, S. M.; Bigner, K.; Calvelage, J.; Preston, K.; Laughlin, A.; Drury, C.; Tincher, B.; Carl, D.; Awosika, O. O.; Boyne, P.

10.1101/2022.12.30.522346 — neuroscience — Posted on 2023-01-02

4033 Predicting alcohol-related memory problems in older adults: A machine learning study with multi-domain features

Kamarajan, C.; Pandey, A. K.; Chorlian, D. B.; Meyers, J. L.; Kinreich, S.; Pandey, G.; Subbie Saenz de Viteri, S.; Zhang, J.; Kuang, W.; Barr, P. B.; Aliev, F.; Anokhin, A. P.; Plawecki, M. H.; Kuperman, S.; Almasy, L.; Merikangas, A.; Brislin, S. J.; Bauer, L.; Hesselbrock, V.; Chan, G.; Kramer, J.; Lai, D.; Hartz, S.; Bierut, L. J.; McCutcheon, V. V.; Bucholz, K. K.; Dick, D. M.; Schuckit, M. A.; Edenberg, H. J.; Porjesz, B.

10.1101/2022.12.30.522330 — neuroscience — Posted on 2023-01-02

4034 Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance in a p53-dependent manner

Stigliani, A.; Ialchina, R.; Yao, J.; Czaplinska, D.; Dai, Y.; Berg Andersen, H.; Andersson, R.; Pedersen, S. F.; Sandelin, A.

10.1101/2023.01.02.522472 — cancer biology — Posted on 2023-01-02

4035 Implementation of a flavin biosynthesis operon improves extracellular electron transfer in bioengineered Escherichia coli

Mouhib, M.; Reggente, M.; Boghossian, A. A.

10.1101/2022.12.31.522390 — bioengineering — Posted on 2023-01-02

4036 Replacing continuous stimulation of one set of electrodes with successive stimulation of multiple sets of electrodes can improve the focality of transcranial temporal interference stimulation (tTIS), especially the focality of stimulation towards deep brain regions: A simulation study.

Li, Y.; Zhang, W.

10.1101/2022.12.30.522357 — bioengineering — Posted on 2023-01-02

4037 Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets

Tahti, E. F.; Blount, J. M.; Jackson, S. N.; Gao, M.; Gill, N. P.; Smith, S. N.; Pederson, N. J.; Rumph, S. N.; Struyvenberg, S. A.; Mackley, I. G. P.; Madden, D. R.; Amacher, J.

10.1101/2022.12.31.522388 — biochemistry — Posted on 2023-01-02

4038 Early infection response of the first trimester human placenta at single-cell scale

Hoo, R.; Ruiz-Morales, E. R.; Kelava, I.; Sancho-Serra, C.; Icoresi Mazzeo, C.; Chelaghma, S.; Tuck, E.; Predeus, A. V.; Fernandez-Antoran, D.; Waller, R. F.; Lee, M.; Vento-Tormo, R.

10.1101/2023.01.02.522155 — genomics — Posted on 2023-01-02

4039 The Trouble with Triples: Examining the Impact of Measurement Error in Mediation Analysis

Gastonguay, M. S.; Keele, G. R.; Churchill, G. A.

10.1101/2022.07.07.499004 — genetics — Posted on 2023-01-02

4040 Regionalized protein localization domains in the hair cell kinocilium

Erickson, T.; Biggers, W. P.; Williams, K.; Venuto, A.

10.1101/2022.12.31.521896 — cell biology — Posted on 2023-01-02

4041 Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cortex

Ghisleni, A.; Bonilla-Quintana, M.; Crestani, M.; Fukuzawa, A.; Rangamani, P.; Gauthier, N.

10.1101/2023.01.02.522381 — cell biology — Posted on 2023-01-02

4042 Regulation of replication origin licensing by ORC phosphorylation reveals a two-step mechanism for Mcm2-7 ring closing

Amasino, A.; Gupta, S.; Friedman, L. J.; Gelles, J.; Bell, S. P.

10.1101/2023.01.02.522488 — molecular biology — Posted on 2023-01-02

4043 CAS12e (CASX2) CLEAVAGE OF CCR5: IMPACT OF GUIDE RNA LENGTH AND PAM SEQUENCE ON CLEAVAGE ACTIVITY

Armstrong, D. A.; Hudson, T. R.; Hodge, C. A.; Hampton, T. H.; Howell, A. L.; Hayden, M. S.

10.1101/2023.01.02.522476 — molecular biology — Posted on 2023-01-02

4044 An engineered ACE2 decoy broadly neutralizes Omicron subvariants and shows therapeutic effect in SARS-CoV-2-infected cynomolgus macaques

Urano, E.; Itoh, Y.; Suzuki, T.; Sasaki, T.; Kishikawa, J.-i.; Akamatsu, K.; Higuchi, Y.; Sakai, Y.; Okamura, T.; Mitoma, S.; Sugihara, F.; Takada, A.; Kimura, M.; Hirose, M.; Sasaki, T.; Koketsu, R.; Tsuji, S.; Yanagida, S.; Shioda, T.; Hara, E.; Matoba, S.; Matsuura, Y.; Kanda, Y.; Arase, H.; Okada, M.; Takagi, J.; Kato, T.; Hoshino, A.; Yasutomi, Y.; Saito, A.; Okamoto, T.

10.1101/2022.12.29.522275 — microbiology — Posted on 2023-01-02

4045 Genotyping of Orientia tsutsugamushi circulating in and around Vellore (South India) using TSA 56 gene

Janaki, K.; Punitha, G.; Lakshmisurya, N.; Gunasekaran, K.; Abhilash, K. P.; Prakash, J. A. J.

10.1101/2022.12.29.522276 — microbiology — Posted on 2023-01-02

4046 Garments that measure EEG: Evaluation of an EEG sensor layer fully implemented with smart textiles

Lopez-Larraz, E.; Escolano, C.; Robledo, A.; Morlas, L.; Alda, A.; Minguez, J.

10.1101/2022.12.31.522227 — neuroscience — Posted on 2023-01-02

4047 Autophagy collaborates with apoptosis pathways to control myelination specificity and function

Zhang, T.; Bae, H.-G.; Bhambri, A.; Zhang, Y.; Barbosa, D.; Xue, J.; Wazir, S.; Mulinyawe, S. B.; Kim, J. H.; Sun, L. O.

10.1101/2022.12.31.522394 — neuroscience — Posted on 2023-01-02

4048 The (Limited?) Utility of Brain Age as a Biomarker for Capturing Cognitive Decline

Tetereva, A.; Pat, N.

10.1101/2022.12.31.522374 — neuroscience — Posted on 2023-01-02

4049 Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes

Wang, G.; Chiou, J.; Zeng, C.; Miller, M.; Matta, I.; Han, J. Y.; Kadakia, N.; Okino, M.-L.; Beebe, E.; Mallick, M.; Camunas-Soler, J.; dos Santos, T.; Dai, X.-Q.; Ellis, C.; Hang, Y.; Kim, S. K.; Macdonald, P. E.; Kandeel, F. R.; Preiss, S.; Gaulton, K.; Sander, M.

10.1101/2022.12.31.522386 — systems biology — Posted on 2023-01-02

4050 OptoCRISPRi-HD: engineering a green-light activated CRISPRi system with high dynamic range

Chen, K.-N.; Ma, B.-G.

10.1101/2022.12.31.522379 — synthetic biology — Posted on 2023-01-02

4051 Oat species and interspecific amphiploids show predominance of diploid nuclei in the syncytial endosperm

Tomaszewska, P.; Kosina, R.

10.1101/2022.12.30.522337 — plant biology — Posted on 2023-01-02

4052 Screening of herbal molecules for the management of Alzheimer's Disorder through molecular docking and in-vitro investigation

Nagu, P.; Pathan, A. K. A.; Mehta, V.

10.1101/2023.01.01.522412 — pharmacology and toxicology — Posted on 2023-01-02

4053 Label-free and non-destructive pathology of human lung adenocarcinomas with ultraviolet single-plane illumination microscopy

Zhang, Y.; Huang, B.; Kang, L.; Tsang, V.; Wu, J.; Kei, L.; Wong, T.

10.1101/2023.01.02.522477 — pathology — Posted on 2023-01-02

4054 Assessment of lisavanbulin (BAL101553) as an anti-lymphoma agent

Spriano, F.; Aresu, L.; Cascione, L.; Risi, G.; Arribas, A. J.; Napoli, S.; Rinaldi, A.; Forster-Gross, N.; Bachmann, F.; Engelhardt, M.; Lane, H.; Bertoni, F.

10.1101/2022.12.31.521730 — cancer biology — Posted on 2023-01-02

4055 ERBB4-mediated signaling is a mediator of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms

Arribas, A. J.; Napoli, S.; Cascione, L.; Barnabei, L.; Sartori, G.; Cannas, E.; Gaudio, E.; Tarantelli, C.; Mensah, A. A.; Spriano, F.; Zucchetto, A.; Rossi, F. M.; Rinaldi, A.; Castro de Moura, M.; Jovic, S.; Bordone Pittau, R.; Stathis, A.; Stussi, G.; Gattei, V.; Brown, J. R.; Esteller, M.; Zucca, E.; Rossi, D.; Bertoni, F.

10.1101/2023.01.01.522017 — cancer biology — Posted on 2023-01-02

4056 HSV-1 Oncolytic Virus Targeting CEACAM6-Expressing Tumors Using a Bispecific T-Cell Engager

Murad, Y. M.; Lee, I.-F.; Liu, X.; Delwar, Z.; Ding, J.; Liu, G.; Tatsiy, O.; Chouljenko, D.; Hussack, G.; Van Faassen, H.; Jia, W. W.-G.

10.1101/2023.01.02.522257 — cancer biology — Posted on 2023-01-02

4057 Arginine limitation causes a directed DNA sequence evolution response in colorectal cancer cells

Hsu, D.; Gao, J.; Yamaguchi, N.; Pinzaru, A.; Mandayam, N.; Liberti, M.; Heissel, S.; Alwaseem, H.; Tavazoie, S.; Tavazoie, S.

10.1101/2023.01.02.521806 — cancer biology — Posted on 2023-01-02

4058 Influence of Electronic Polarization on the Binding of Anions to a Chloride-Pumping Rhodopsin

Phan, L. X.; Chamorro, V. C.; Martinez-Seara, H.; Crain, J.; Sansom, M.; Tucker, S. J.

10.1101/2022.12.31.522380 — biophysics — Posted on 2023-01-02

4059 Qualitative assessment of cryo-EM map reconstruction

Nidamarthi, K. H. V.

10.1101/2022.12.31.521834 — biophysics — Posted on 2023-01-02

4060 Development of digital Hi-C assay

Mori, A.; Schweikert, G.

10.1101/2022.12.31.522397 — bioinformatics — Posted on 2023-01-02

4061 The new mega dataset combined with a deep neural network makes progress in predicting the impact of single mutations on protein stability

Pak, M. A.; Dovidchenko, N. V.; Sharma, S. M.; Ivankov, D. N.

10.1101/2022.12.31.522396 — bioinformatics — Posted on 2023-01-02

4062 The Identification of Key Genes and Biological Pathways in Polycystic Ovary Syndrome and its Complications by Next Generation Squancing (NGS) and Bioinformatics Analysis

Vastrad, B. M.; Vastrad, C. M.

10.1101/2022.12.29.522191 — bioinformatics — Posted on 2023-01-02

4063 RGT: a toolbox for the integrative analysis of high throughput regulatory genomics data

Li, Z.; Kuo, C.-C.; Ticconi, F.; Shaigan, M.; Gusmao, E. G.; Allhoff, M.; Manolov, M.; Zenke, M.; Gesteira Costa Filho, I.

10.1101/2022.12.31.522372 — bioinformatics — Posted on 2023-01-02

4064 On the correspondence between the transcriptomic response of a compound and its effects on its targets

Engler Hart, C.; Ence, D.; Healey, D.; Domingo-Fernandez, D.

10.1101/2023.01.01.522411 — bioinformatics — Posted on 2023-01-02

4065 Design and fabrication of a low-cost microfluidic cartridge with integrated pressure-driven check valve for molecular diagnostics platforms

Downen, R. S.; Dong, Q.; Chen, J. L.; Li, Z.

10.1101/2022.12.29.522222 — bioengineering — Posted on 2023-01-02

4066 The online metacognitive control of decisions

Lee, D. G.; Benon, J.; Hopper, W.; Verdeil, M.; Pessiglione, M.; Vinckier, F.; Bouret, S.; Rouault, M.; Lebouc, R.; Pezzulo, G.; Schreiweis, C.; Burguiere, E.; Daunizeau, J.

10.1101/2023.01.02.522463 — animal behavior and cognition — Posted on 2023-01-02

4067 AgamPrimer: Primer Design in Anopheles gambiae informed by range-wide genomic variation

Nagi, S. C.; Miles, A.; Donnelly, M. J.

10.1101/2022.12.31.521737 — genomics — Posted on 2023-01-02

4068 Order of events in a developing genetic code

Yarus, M.

10.1101/2022.12.31.522385 — evolutionary biology — Posted on 2023-01-02

4069 Individualistic attitudes in iterative Prisoners Dilemma undermine evolutionary fitness and may drive cooperative human players to extinction

Pulcu, E.

10.1101/2023.01.02.522489 — evolutionary biology — Posted on 2023-01-02

4070 Early life drought predicts components of adult body size in wild female baboons

Levy, E. J.; Lee, A.; Siodi, I. L.; Helmich, E. C.; McLean, E. R.; Malone, E. J.; Pickard, M. J.; Ranjithkumar, R.; Tung, J.; Archie, E.; Alberts, S. C.

10.1101/2023.01.02.522387 — ecology — Posted on 2023-01-02

4071 Atheroprone shear stress stimulates noxious endothelial extracellular vesicle uptake by MCAM and PECAM-1 cell adhesion molecules

Coly, P.-M.; Chatterjee, S.; Mezine, F.; El Jekmek, C.; Devue, C.; Nipoti, T.; Lara Corona, M.; Dingli, F.; Loew, D.; van Niel, G.; Boulanger, C. M.

10.1101/2022.12.31.522373 — cell biology — Posted on 2023-01-02

4072 Trafficking of nuclear-encoded apicoplast proteins depends on F-actin and Myosin F in Toxoplasma gondii

Devarakonda, P. M.; Sarmiento, V.; Heaslip, A. T.

10.1101/2023.01.01.521342 — cell biology — Posted on 2023-01-02

4073 Meiotic Cells Escape Prolonged Spindle Checkpoint Activity Through Premature Silencing and Slippage

MacKenzie, A.; Vicory, V.; Lacefield, S.

10.1101/2023.01.02.522494 — cell biology — Posted on 2023-01-02

4074 Extracellular succinate induces spatially organized biofilm formation in Clostridioides difficile

Auria, E.; Deschamps, J.; Briandet, R.; Dupuy, B.

10.1101/2023.01.02.522461 — microbiology — Posted on 2023-01-02

4075 Genomics of the "tumorigenes" clade of the family Rhizobiaceae and description of Rhizobium rhododendri sp. nov.

Kuzmanovic, N.; diCenzo, G. C.; Bunk, B.; Sproeer, C.; Fruehling, A.; Neumann-Schaal, M.; Overmann, J.; Smalla, K.

10.1101/2023.01.02.522471 — microbiology — Posted on 2023-01-02

4076 Cellular Immune Responses Induced by Subretinal AAV Gene Transfer can be Restrained by the Subretinal Associated Immune Inhibition Mechanism

VENDOMELE, J.; CHAUVEAU, G. A.; DALKARA, D.; Galy, A.; FISSON, S.

10.1101/2022.12.30.522324 — immunology — Posted on 2023-01-02

4077 KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response

Ager, C. R.; Zhang, M.; Chaimowitz, M.; Bansal, S.; Obradovic, A.; Rogava, M.; Melms, J. C.; McCann, P.; Spina, C.; Drake, C. G.; Dallos, M. C.; Izar, B.

10.1101/2023.01.01.522340 — immunology — Posted on 2023-01-02

4078 Population-level neural correlates of flexible avoidance learning in medial prefrontal cortex

Ehret, B.; Boehringer, R.; Amadei, E. A.; Cervera, M. R.; Galgali, A.; Henning, C.; Mante, V.; Grewe, B. F.

10.1101/2022.12.31.522384 — neuroscience — Posted on 2023-01-02

4079 Induced Alpha And Beta Electroencephalographic Rhythms Covary With Single-Trial Speech Intelligibility In Competition

Viswanathan, V.; Bharadwaj, H. M.; Heinz, M. G.; Shinn-Cunningham, B. G.

10.1101/2022.12.31.522365 — neuroscience — Posted on 2023-01-02

4080 Analysis of the genome-scale metabolic model of Bacillus subtilis to design novel in-silico strategies for native and recombinant L-asparaginase overproduction

Barge, N. S.; Sahoo, A.; Dasu, V. V.

10.1101/2022.12.29.522229 — systems biology — Posted on 2023-01-02

4081 Genetic Divergence Analysis among Sesame (Sesamum Indicum L.) Accessions in Middle Awash, Ethiopia

Gimbichu, M. T.; Gurmu, G. N.; Ayana, N. G.

10.1101/2022.12.29.522196 — plant biology — Posted on 2023-01-02

4082 Sex allocation plasticity in response to resource and pollination availability in the annual plant Brassica rapa (Brassicaceae)

Kostur, N.; Wadgymar, S. M.

10.1101/2022.12.30.522342 — plant biology — Posted on 2023-01-02

4083 Androgen-mediated TGFβ expression suppresses anti-tumor neutrophil response in bone metastatic prostate cancer

Alsamraae, M.; Costanzo-Garvey, D.; Teply, B.; Sommerville, G.; Herbert, Z.; Morrissey, C.; Abdalla, M. Y.; Fallet, R. W.; Kielian, T.; Jensen-Smith, H.; deOliveira, E. I.; Chen, K.; Bettencourt, I.; Wang, J. M.; Keeley, T.; Yu, F.; Cook, L. M.

10.1101/2022.12.30.522329 — cancer biology — Posted on 2023-01-02

4084 The reprogrammed mouse heart phosphoproteome in response to the chronic stress of markedly high cardiac-specific adenylyl cyclase type 8 overexpression

Qu, J.-H.; Chakir, K.; Tarasov, K. V.; Riordon, D. R.; Perino, M. G.; Silvester, A. J.; Lakatta, E. G.

10.1101/2022.04.29.488779 — bioinformatics — Posted on 2023-01-02

4085 Towards a unified theory of the reference frame of the ventriloquism aftereffect

Loksa, P.; Kopco, N.

10.1101/2021.03.31.437664 — neuroscience — Posted on 2023-01-02

4086 Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair

Sun, X.; Li, S.; He, Y.; Liu, Y.; Ma, T.; Zeng, R.; Liu, Z.; Chen, Y.; Zheng, Y.; Liu, X.

10.1101/2022.11.24.517620 — bioengineering — Posted on 2023-01-02

Archive, 2023-01