bioRxiv directory

2 Fungal community dynamics and carbon mineralization in coarse woody debris across decay stage, tree species, and stand development stage in northern boreal forests

Hart, S.; Porter, T. M.; Basiliko, N.; Venier, L.; Hajibabaei, M.; Morris, D.

10.1101/2022.01.31.478531 — ecology — Posted on 2022-01-31

3 Oo-site: A dashboard to visualize gene expression during Drosophila oogenesis reveals meiotic entry is regulated post-transcriptionally

Martin, E. T.; Sarkar, K.; McCarthy, A.; Rangan, P.

10.1101/2022.01.31.478569 — developmental biology — Posted on 2022-01-31

4 A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy.

Tomer, D.; Arriagada, C.; Munshi, S.; Alexander, B.; French, B.; Vedula, P.; Caorsi, V.; House, A.; Guvendiren, M.; Kashina, A.; Schwarzbauer, J.; Astrof, S.

10.1101/2020.09.09.290130 — cell biology — Posted on 2022-01-31

5 The Growth Hormone Releasing Hormone Signaling Pathway Governs Cardiomyocyte differentiation in human iPS cells.

Wanschel, A.; Salerno, A. G.; Kuznetsov, J.; Kurtenbach, S.; Rodriguez, D. A.; Valasaki, K.; Balkan, W.; Dykxhoorn, D.; Schally, A.; Hare, J.; Chatzistergos, K.

10.1101/2022.01.31.478572 — cell biology — Posted on 2022-01-31

6 Local IL-17 orchestrates skin aging

Sola, P.; Mereu, E.; Bonjoch, J.; Casado, M.; Reina Garcia, O.; Blanco Garcia, E.; Esteller, M.; DiCroce, L.; Heyn, H.; Solanas, G.; Aznar Benitah, S.

10.1101/2022.01.31.478459 — cell biology — Posted on 2022-01-31

7 Three-dimensional analysis and in vivo imaging for sperm release and transport in the murine seminiferous tubule

Kanazawa, Y.; Omotehara, T.; Nakata, H.; Hirashima, T.; Itoh, M.

10.1101/2022.01.31.478089 — cell biology — Posted on 2022-01-31

8 Single-cell atlas of epithelial and stromal cell heterogeneity by lobe and strain in the mouse prostate

Graham, M. K.; Chikarmane, R.; Wang, R.; Vaghasia, A. M.; Gupta, A.; Zheng, Q.; Wodu, B. P.; Pan, X.; Castagna, N.; Liu, J.; Meyers, J.; Skaist, A.; Wheelan, S. J.; Simons, B. W.; Bieberich, C.; Nelson, W.; DeWeese, T. L.; De Marzo, A. M.; Yegnasubramanian, S.

10.1101/2022.01.31.478481 — cell biology — Posted on 2022-01-31

9 Single-cell transcriptomics of dynamic cell behaviors

Vinarsky, V.; Haber, A.; Kwok, S. J.; Yun, S.-H.; Montoro, D. T.

10.1101/2022.01.31.478519 — cell biology — Posted on 2022-01-31

10 Analysis of secondary metabolite gene clusters and chitin biosynthesis pathways of Monascus purpureus with high production of pigment and citrinin based on whole-genome sequencing

Zhang, S.; Zeng, X.; Lin, Q.; Liu, J.

10.1101/2022.01.31.478530 — microbiology — Posted on 2022-01-31

11 Expansion and contraction of resource allocation in sensory bottlenecks

Edmondson, L. R.; Jimenez Rodriguez, A.; Saal, H. P.

10.1101/2021.05.26.445857 — neuroscience — Posted on 2022-01-31

12 Sequestration of TDP-43216-414 aggregates by cytoplasmic expression of the proSAAS chaperone

Peinado, J. R.; Chaplot, K.; Jarvela, T. S.; Barbieri, E.; Shorter, J.; Lindberg, I.

10.1101/2020.04.15.039578 — neuroscience — Posted on 2022-01-31

13 In-vivo egfp expression in the honeybee Apis mellifera induced by electroporation and viral expression vector.

Leboulle, G.; Gehne, N.; Froese, A.; Menzel, R.

10.1101/2022.01.31.478532 — neuroscience — Posted on 2022-01-31

14 Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons

Upchurch, C.; Combe, C. L.; Knowlton, C.; Rousseau, V. G.; Gasparini, S.; Canavier, C. C.

10.1101/2021.10.26.465936 — neuroscience — Posted on 2022-01-31

15 Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies

Sawada, H.; Katsumata, Y.; Higashi, H.; Zhang, C.; Li, Y.; Morgan, S.; Lee, L. H.; Singh, S. A.; Chen, J. Z.; Howatt, D. A.; Moorleghen, J. J.; Franklin, M. K.; Rateri, D. L.; Shen, Y. H.; LeMaire, S. A.; Aikawa, M.; Majesky, M. W.; Lu, H. S.; Daugherty, A.

10.1101/2020.02.02.930917 — pathology — Posted on 2022-01-31

16 Collective polymerase dynamics emerge from DNA supercoiling during transcription

Sevier, S.; Hormoz, S.

10.1101/2021.11.24.469850 — biophysics — Posted on 2022-01-31

17 Inferring ongoing cancer evolution from single tumour biopsies using synthetic supervised learning

Ouellette, T. W.; Awadalla, P.

10.1101/2021.11.22.469566 — bioinformatics — Posted on 2022-01-31

18 SpatialExperiment: infrastructure for spatially resolved transcriptomics data in R using Bioconductor

Righelli, D.; Weber, L. M.; Crowell, H. L.; Pardo, B.; Collado-Torres, L.; Ghazanfar, S.; Lun, A. T.; Hicks, S. C.; Risso, D.

10.1101/2021.01.27.428431 — bioinformatics — Posted on 2022-01-31

19 Plant Scaffolds Support Motor Recovery and Regeneration in Rats after Traumatic Spinal Cord Injury

Modulevsky, D. J.; Cuerrier, C. M.; Leblanc-Latour, M.; Hickey, R. J.; Obhi, R.-J. K.; Shore, I.; Galuta, A.; Walker, K. L. A.; Tsai, E. C.; Pelling, A. E.

10.1101/2020.10.21.347807 — bioengineering — Posted on 2022-01-31

20 Different contribution of the monkey prefrontal and premotor dorsal cortex in decision making during a transitive inference task

Ramawat, S.; Mione, V.; Di Bello, F.; Bardella, G.; Genovesio, A.; Pani, P.; Ferraina, S.; Brunamonti, E.

10.1101/2021.07.26.453792 — animal behavior and cognition — Posted on 2022-01-31

21 In vitro evolution of uracil glycosylase towards DnaKJ and GroEL binding evolves different misfolded states

Melanker, O.; Goloubinoff, P. A.; Schreiber, G.

10.1101/2021.11.30.470542 — evolutionary biology — Posted on 2022-01-31

22 Host evolutionary history and ecological context modulate the adaptive potential of the microbiome

Henry, L.; Fernandez, M.; Webb, A.; Ayroles, J. F.

10.1101/2020.09.21.306779 — evolutionary biology — Posted on 2022-01-31

23 Succession comprises a sequence of threshold-induced community assembly processes towards multidiversity

Hanusch, M.; He, X.; Ruiz-Hernandez, V.; Junker, R. R.

10.1101/2021.05.18.444608 — ecology — Posted on 2022-01-31

24 Human Cytomegalovirus modifies placental small extracellular vesicle secretion and composition towards a proviral phenotype to enhance infection of fetal recipient cells

Bergamelli, M.; Martin, H.; Aubert, Y.; Mansuy, J.-M.; Marcellin, M.; Burlet-Schiltz, O.; Hurbain, I.; Raposo, G.; Izopet, J.; Fournier, T.; Benchoua, A.; Benard, M.; Groussolles, M.; Cartron, G.; Tanguy le Gac, Y.; Moinard, N.; D'Angelo, G.; Malnou, C. E.

10.1101/2021.11.18.468660 — cell biology — Posted on 2022-01-31

25 Dynamic Turnover of PI4P and PI(4,5)P2 under Hypoxia Controls Electrostatic Plasma Membrane Targeting

Lu, J.; Dong, W.; Hammond, G. R.; Hong, Y.

10.1101/2022.01.07.475384 — cell biology — Posted on 2022-01-31

26 Hsp78-interaction proteome highlights chaperone role during protein aggregation in mitochondria under heat stress

Jaworek, W.; Sylvester, M.; Cenini, G.; Voos, W.

10.1101/2022.01.28.478199 — cell biology — Posted on 2022-01-31

27 Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction

Sugihara, K.; Kitamoto, S.; Saraithong, P.; Nagao-Kitamoto, H.; McCarthy, C.; Hoostal, M.; Rosevelt, A.; Muraleedharan, C. K.; Gillilland, M. G.; Imai, J.; Omi, M.; Bishu, S.; Kao, J. Y.; Alteri, C.; Barnich, N.; Schmidt, T. M.; Nusrat, A.; Inohara, N.; Golob, J. L.; Kamada, N.

10.1101/2022.01.17.476631 — microbiology — Posted on 2022-01-31

28 Effect of stimulation time on the expression of human macrophage polarization markers

Unuvar Purcu, D.; Korkmaz, A.; Gunalp, S.; Helvaci, D. G.; Erdal, Y.; Dogan, Y.; Suner, A.; Wingender, G.; Sag, D.

10.1101/2021.07.26.453762 — immunology — Posted on 2022-01-31

29 Neurons from individual early Alzheimer's disease patients reflect clinical vulnerability

Ng, B.; Rowland, H. A.; Wei, T.; Arunasalam, K.; Hayes, E. M.; Koychev, I.; Hedegaard, A.; Ribe, E. M.; Chan, D.; Chessell, T.; ffytche, D.; Gunn, R. N.; Kocagoncu, E.; Lawson, J.; Malhotra, P.; Ridha, B. H.; Rowe, J. B.; Thomas, A. J.; Zamboni, G.; Buckley, N.; Cader, Z. M.; Lovestone, S.; Wade-Martins, R.

10.1101/2021.11.09.467891 — neuroscience — Posted on 2022-01-31

30 A partially nested cortical hierarchy of neural states underlies event segmentation in the human brain

Geerligs, L.; Gözükara, D.; Oetringer, D.; Campbell, K.; van Gerven, M.; Güclü, U.

10.1101/2021.02.05.429165 — neuroscience — Posted on 2022-01-31

31 Guiding Irregular Nuclear Morphology on Nanopillar Array for Malignancy Differentiation in Tumor cells

Zeng, Y.; Zhuang, Y.; Mitra, A.; Chen, P.; Saggio, I.; Shivashankar, G. V.; Gao, W.; Zhao, W.

10.1101/2022.01.30.478168 — bioengineering — Posted on 2022-01-31

32 Adaptive scans allow targeted cell-ablations on curved cell sheets

Meng, H.; Nuzhdin, D.; Sison, M.; Galland, F.; le goff, l.

10.1101/2022.01.30.478374 — biophysics — Posted on 2022-01-31

33 Constructing Causal Cytokine Networks for Autoimmune and Inflammatory Diseases Target Identification

Chen, Y.

10.1101/2022.01.30.478394 — bioinformatics — Posted on 2022-01-31

34 Extracellular vesicle microRNA cargo engineering reveals critical mechanisms underlying therapeutic efficacy

Euscher, L. M.; Mentkowski, K. I.; Tarvirdizadeh, T.; Julian, I.; Bhatt, K. D.; Eagler, L. A.; Lang, J. K.

10.1101/2022.01.31.478505 — bioengineering — Posted on 2022-01-31

35 Non-canonical scaffold-type ligase complex mediates protein UFMylation

Peter, J. J.; Magnussen, H. M.; DaRosa, P. A.; Millrine, D.; Matthews, S. P.; Lamoliatte, F.; Sundaramoorthy, R.; Kopito, R. R.; Kulathu, Y.

10.1101/2022.01.31.478489 — biochemistry — Posted on 2022-01-31

36 Exploring the possible role of hybridization in the evolution of photosynthetic pathways in Flaveria (Asteraceae), the prime model of C4 photosynthesis evolution

Morales-Briones, D. F.; Kadereit, G.

10.1101/2022.01.31.478436 — evolutionary biology — Posted on 2022-01-31

37 A cross taxonomic comparison of bird and butterfly communities of Tamhini Wildlife Sanctuary across two decades.

Dsouza, S.; Padhye, A.

10.1101/2022.01.30.478416 — ecology — Posted on 2022-01-31

38 Revisiting degron motifs in human AURKA required for its targeting by APC/C-FZR1

Lindon, C.; Abdelbaki, A. A.; Ascanelli, C.; Okoye, C.; Akman, H. B.; Janson, G.; Min, M.-w.; Marcozzi, C.; Hagting, A.; Grant, R.; De Luca, M.; Asteriti, I. A.; Guarguaglini, G.; Paiardini, A.

10.1101/2022.01.31.478464 — cell biology — Posted on 2022-01-31

39 Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export.

Gomez-Navarro, N.; Maldutyte, J.; Poljak, K.; Peak-Chew, S.-Y.; Orme, J.; Bisnett, B.; Lamb, C. H.; Boyce, M.; Gianni, D.; Miller, E. A.

10.1101/2022.01.31.478454 — cell biology — Posted on 2022-01-31

40 Domain expansion and functional diversification in vertebrate reproductive proteins

Rivera, A. M.; Wilburn, D. B.; Swanson, W. J.

10.1101/2022.01.31.478407 — molecular biology — Posted on 2022-01-31

41 Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state

Kipper, K.; Mansour, A.; Tobiasson, V.; Pulk, A.

10.1101/2022.01.31.478155 — molecular biology — Posted on 2022-01-31

42 Intervertebral disc cell chondroptosis elicits neutrophil response in Staphylococcus aureus spondylodiscitis

Schweizer, T. A.; Andreoni, F.; Acevedo, C.; Scheier, T. C.; Heggli, I.; Marques Maggio, E.; Eberhard, N.; Brugger, S. D.; Dudli, S.; Zinkernagel, A. S.

10.1101/2022.01.31.478414 — immunology — Posted on 2022-01-31

43 Orexin action on the dopaminergic system modulates theta during REM sleep and wakefulness

Bandarabadi, M.; Li, S.; Tafti, M.; Colombo, G.; Becchetti, A.; Vassalli, A.

10.1101/2022.01.30.478401 — neuroscience — Posted on 2022-01-31

44 Orally active mGluR2/3 metabotropic antagonist pro-drug mimics the beneficial effects of physical exercise on neurogenesis, behavior, and exercise-related molecular pathways in an Alzheimer's disease mouse model

Perez-Garcia, G.; Bicak, M.; Buros, J.; Haure-Mirande, J.-V.; Perez, G. M.; Otero-Pagan, A.; Sosa, M. A. G.; De Gasperi, R.; Sano, M.; Gage, F. H.; Barlow, C.; Dudley, J. T.; Glicksberg, B. S.; Wang, Y.; Readhead, B.; Ehrlich, M. E.; Elder, G. A.; Gandy, S.

10.1101/2022.01.31.477906 — neuroscience — Posted on 2022-01-31

45 Common signatures of differential microRNA expression in Parkinson's and Alzheimer's disease brains

Dobricic, V.; Schilling, M.; Farkas, I.; Gveric, D.; Schulz, J.; Middleton, L.; Gentleman, S.; Parkkinen, L.; Bertram, L.; Lill, C. M.

10.1101/2022.01.31.478486 — neuroscience — Posted on 2022-01-31

46 CRISPR/Cas9 gene editing uncovers the role of CTR1 and ROS1 in melon fruit ripening and epigenetic regulation

Giordano, A. M.; Santo Domingo, M.; Quadrana, L.; Pujol, M.; Martin-Hernandez, A. M.; Garcia-Mas, J.

10.1101/2022.01.30.478227 — plant biology — Posted on 2022-01-31

47 In vitro direct regeneration and Agrobacterium tumefaciens mediated in planta transformation of Ocimum sanctum L.

Khan, S.; Husain, Z.; Rahman, L. U.

10.1101/2022.01.31.478449 — plant biology — Posted on 2022-01-31

48 Evaluation of PRKACA as a Therapeutic Target for Fibrolamellar Carcinoma

Schalm, S. S.; O'Hearn, E.; Wilson, K.; LaBranch, T. P.; Silva, G.; Zhang, Z.; DiPietro, L.; Bifulco, N.; Woessner, R.; Stransky, N.; Sappal, D.; Campbell, R.; Lobbardi, R.; Palmer, M.; Kim, J.; Ye, C.; Dorsch, M.; Lengauer, C.; Guzi, T.; Kadambi, V.; Garner, A.; Hoeflich, K. P.

10.1101/2022.01.31.477690 — cancer biology — Posted on 2022-01-31

49 Pseudotime analysis reveals novel regulatory factors for multigenic onset and monogenic transition of odorant receptor expression

Hussainy, M.; Korsching, S. I.; Tresch, A.

10.1101/2022.01.31.478392 — bioinformatics — Posted on 2022-01-31

50 The evolution of coordination: A phylogenetic meta-analysis and systematic review

Keeble, L.; Wallenberg, J.; Price, E. E.

10.1101/2022.01.31.478450 — animal behavior and cognition — Posted on 2022-01-31

51 Expanded Analysis of Pigmentation Genetics in UK Biobank

Pairo-Castineira, E.; Cornelissen, J.; Rawlik, K.; Canela-Xandri, O.; Loftus, S. K.; Pavan, W. J.; Brown, K. M.; Tenesa, A.; Jackson, I. J.

10.1101/2022.01.30.478418 — genetics — Posted on 2022-01-31

52 Flagellar energy costs across the Tree of Life

Schavemaker, P. E.; Lynch, M.

10.1101/2022.01.31.478446 — evolutionary biology — Posted on 2022-01-31

53 Reproductive strategies in a complex of simultaneously hermaphroditic species, the Allolobophora chlorotica case study

Dupont, L.; Audusseau, H.; Porco, D.; Butt, K. R.

10.1101/2022.01.31.475338 — evolutionary biology — Posted on 2022-01-31

54 Exploring the thermal limits of malaria transmission in the western Himalaya

Mozaffer, F.; Menon, G. I.; Ishtiaq, F.

10.1101/2022.01.31.478411 — ecology — Posted on 2022-01-31

55 Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer

Pariollaud, M.; Ibrahim, L. H.; Irizarry, E.; Mello, R. M.; Chan, A. B.; Altman, B. J.; Shaw, R. J.; Bollong, M. J.; Wiseman, L.; Lamia, K. A.

10.1101/2022.01.31.478213 — cell biology — Posted on 2022-01-31

56 A subset of gut leukocytes have telomerase-dependent 'hyper-long' telomeres and require telomerase for function in zebrafish

Ellis, P. S.; Martins, R. R.; Thompson, E.; Farhat, A.; Renshaw, S. A.; Henriques, C. M.

10.1101/2022.01.31.478480 — cell biology — Posted on 2022-01-31

57 A Novel Cytoskeletal Action of Xylosides

Mencio, C. P.; Tilve, S. M.; Suzuki, M.; Higashi, K.; Katagiri, Y.; Geller, H. M.

10.1101/2022.01.31.478500 — cell biology — Posted on 2022-01-31

58 Peptide location fingerprinting identifies species- and tissue-conserved structural remodelling of proteins as a consequence of ageing and disease

Eckersley, A.; Ozols, M.; Chen, P.; Tam, V.; Ward, L. J.; Hoyland, J. A.; Trafford, A.; Yuan, X.-M.; Schiller, H. B.; Chan, D.; Sherratt, M. J.

10.1101/2022.01.31.478441 — molecular biology — Posted on 2022-01-31

59 A novel fully-spliced accessory gene in equine lentivirus with distinct Rev-responsive element

Zhang, X.; Li, J.; Zhang, M.; Bai, B.; Ma, W.; Lin, Y.; Guo, X.; Wang, X.-F.; Wang, X.

10.1101/2022.01.30.478423 — molecular biology — Posted on 2022-01-31

60 Chromatin-associated microprocessor assembly is regulated by PRP40, the U1 snRNP auxiliary protein

Stepien, A.; Dolata, J.; Gulanicz, T.; Bielewicz, D.; Bajczyk, M.; Smolinski, D. J.; Szweykowska-Kulinska, Z.; Jarmolowski, A.

10.1101/2022.01.31.478465 — molecular biology — Posted on 2022-01-31

61 Repair of Mismatched Templates during Rad51-dependent Break-Induced Replication

Choi, J.; Gallagher, D. N.; Li, K.; Bronk, G.; Haber, J. E.

10.1101/2022.01.30.478419 — molecular biology — Posted on 2022-01-31

62 Significant Broad Spectrum Antiviral activity of Bi121 Against Different Variants of SARS-CoV-2

Subhadra, B.; Agrawal, R.; Pal, V. K.; Chenine, A.; Mattathil, J. G.; Singh, A.

10.1101/2022.01.29.477140 — microbiology — Posted on 2022-01-31

63 Whole-Genome Sequence of African Swine Fever Virus isolate from India provides insights into diversity and evolution

Mahajan, S.; Doley, J.; Subramaniam, S.; Yadav, A. K.; Pegu, S. R.; Mohan, N. H.; chander, V.; Mathesh, K.; Nandi, S.; Singh, K. P.; Gupta, V. K.; Sharma, G. K.

10.1101/2022.01.31.478458 — microbiology — Posted on 2022-01-31

64 Diurnal differences in intracellular replication within splenic macrophages correlates with the outcome of pneumococcal infection.

Hames, R. G.; Jasiunaite, Z.; Ercoli, G.; Wanford, J. J.; Carreno, D.; Straatman, K.; Martinez-Pomares, L.; Yesilkaya, H.; Glenn, S.; Moxon, E. R.; Andrew, P. W.; Kyriacou, C. P.; Oggioni, M. R.

10.1101/2022.01.30.478422 — microbiology — Posted on 2022-01-31

65 Myxoma virus lacking the host range determinant M062 stimulates cGAS-dependent type 1 interferon response and unique transcriptomic changes in human macrophages

Conrad, S. J.; Peterson, E. A.; Liem, J.; Connor, R.; Nounamo, B.; Cannon, M.; Liu, J.

10.1101/2022.01.30.478420 — immunology — Posted on 2022-01-31

66 Ornithine Lipid Activates Both TLR4 and the non-canonical NLRP3 Inflammasome.

Pizzuto, M.; Hurtado-Navarro, L.; Molina-Lopez, C.; Soubhye, J.; Gelbcke, M.; Rodriguez-Lopez, S.; Ruysschaert, J.-M.; Pelegrin, P.

10.1101/2022.01.28.477396 — immunology — Posted on 2022-01-31

67 High-resolution structural analysis of enterovirus-reactive polyclonal antibodies in complex with whole virions

Antanasijevic, A.; Schulze, A. J.; Reddy, V. S.; Ward, A. B.

10.1101/2022.01.31.478566 — immunology — Posted on 2022-01-31

68 Recipient LAG3 deficiency results in antibody-mediated rejection of mouse renal allografts

Nicosia, M.; Fan, R.; Lee, J.; Gorbacheva, V.; Beavers, A.; Dvorina, N.; Baldwin, W.; Fairchild, R. L.; Min, B.; Valujskikh, A.

10.1101/2022.01.31.478518 — immunology — Posted on 2022-01-31

69 Acyl ghrelin attenuates neurochemical and motor deficits in the 6OHDA model of Parkinsons disease

Rees, D. J.; Johnson, A. L.; Lelos, M. J.; Smith, G. A.; Roberts, L. D.; Phelps, L. H.; Dunnett, S. B.; Morgan, A. H.; Brown, R.; Wells, T.; Davies, J. S.

10.1101/2022.01.31.478447 — neuroscience — Posted on 2022-01-31

70 Do place cells dream of deceptive moves in a signaling game?

Fenton, A. A.; Hurtado, J. R.; Broek, J. A. C.; PARK, E. H.; Mishra, B.

10.1101/2022.01.30.478398 — neuroscience — Posted on 2022-01-31

71 Impact of APOE e3 and e4 genotypes on plasma proteome signatures in Alzheimer's disease

Kaur, G.; Poljak, A.; Masters, C. L.; Fowler, C.; Sachdev, P.

10.1101/2022.01.29.478291 — neuroscience — Posted on 2022-01-31

72 Glia of C. elegans coordinate the heat shock response independent of the neuronal thermosensory circuit and serotonin

Gildea, H. K.; Frankino, P. A.; Tronnes, S. U.; Pender, C. L.; Choi, H. O.; Hunter, T. D.; Cheung, S. S.; Frakes, A. E.; Sukarto, E.; Dillin, A.

10.1101/2022.01.31.478522 — neuroscience — Posted on 2022-01-31

73 Origin of hexagonal metric of grid cells in navigating spaces

Zhang, B.; Zhang, Y.; Liu, J.

10.1101/2022.01.29.478346 — neuroscience — Posted on 2022-01-31

74 Cerebellar transcranial direct current stimulation disrupts neuroplasticity of intracortical motor circuits.

Liao, W.-y.; Sasaki, R.; Semmler, J. G.; Opie, G. M.

10.1101/2022.01.30.478397 — neuroscience — Posted on 2022-01-31

75 A novel role of 3,5-cAMP in the regulation of actin cytoskeleton in Arabidopsis.

Chodasiewicz, M.; Fuentealba, N. F.; Franz, P.; Luzarowski, M.; Moreno, J. C.; Childs, D.; Masiuk, A.; Saluja, M.; Sampathkumar, A.; Skirycz, A.

10.1101/2022.01.31.478439 — plant biology — Posted on 2022-01-31

76 Highly efficient, all-organic bioluminescence-photosensitizer conjugate eradicates early-stagetumors and prevents metastasis in mice

Yan, H.; Forward, S.; Kim, K.-H.; Wu, Y.; Hui, J.; Kashiparekh, A.; Yun, S.-H.

10.1101/2022.01.29.478339 — cancer biology — Posted on 2022-01-31

77 Unfolding and identification of membrane proteins in situ

Galvanetto, N.; Ye, Z.; Marchesi, A.; Mortal, S.; Maity, S.; Laio, A.; Torre, V.

10.1101/732933 — biophysics — Posted on 2022-01-31

78 Active site center redesign increases protein stability preserving catalysis

Romero-Romero, M. L.; Garcia-Seisdedos, H.; Ibarra-Molero, B.

10.1101/2022.01.31.478513 — biophysics — Posted on 2022-01-31

79 Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane

Lisica, A.; Fouchard, J.; Kelkar, M.; Wyatt, T. P.; Duque, J.; Ndiaye, A.-B.; Bonfanti, A.; Baum, B.; Kabla, A.; Charras, G.

10.1101/2022.01.30.478396 — biophysics — Posted on 2022-01-31

80 Making sense of disorder: Investigating intrinsically disordered proteins in the tardigrade proteome via a computational approach

Lowe, N. E.; Chang, R. L.

10.1101/2022.01.29.478329 — bioinformatics — Posted on 2022-01-31

81 Neural network for the prediction of treatment response in triple negative breast cancer

Naylor, P.; Lazard, T.; Bataillon, G.; Lae, M.; Vincent-Salomon, A.; Hamy, A.-S.; Reyal, F.; Walter, T.

10.1101/2022.01.31.478433 — bioinformatics — Posted on 2022-01-31

82 A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA

Liu, X.; Gaubitz, C.; Pajak, J.; Kelch, B. A.

10.1101/2022.01.31.478526 — biochemistry — Posted on 2022-01-31

83 Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP

Imaizumi, Y.; Takanuki, K.; Miyake, T.; Takemoto, M.; Hirata, K.; Hirose, M.; Oi, R.; Kobayashi, T.; Miyoshi, K.; Aruga, R.; Yokoyama, T.; Katagiri, S.; Matsuura, H.; Iwasaki, K.; Kato, T.; Kaneko, M. K.; Kato, Y.; Tajiri, M.; Akashi, S.; Nureki, O.; Hizukuri, Y.; Akiyama, Y.; Nogi, T.

10.1101/2022.01.31.478169 — biochemistry — Posted on 2022-01-31

84 Spatial Venomics - Cobra Venom System Reveals Spatial Differentiation of Snake Toxins by Mass Spectrometry Imaging

Hempel, B.-F.; Damm, M.; Petras, D.; Kazandjian, T. D.; Szentiks, C. A.; Fritsch, G.; Nebrich, G.; Casewell, N. R.; Klein, O.; Süssmuth, R. D.

10.1101/2022.01.31.478453 — biochemistry — Posted on 2022-01-31

85 Indigenous peoples in eastern Brazil: insights from 19th century genomes and metagenomes

Cruz Davalos, D. I.; Arizmendi Cardenas, Y. O.; Bravo-Lopez, M. J.; Neuenschwander, S.; Reis, S.; Bastos, M. Q. R.; Stenderup, J.; Yediay, F. E.; Villa-Islas, V.; Reyna-Blanco, C. S.; Rodrigues-Carvalho, C.; Hünemeier, T.; Allentoft, M. E.; Amorim, C. E. G.; Moreno-Mayar, J. V.; Avila-Arcos, M. C.; Malaspinas, A.-S.

10.1101/2022.01.27.477466 — genomics — Posted on 2022-01-31

86 Role of mucin gene for growth in Anas platyrynchos - a novel report

Murmu, A. K.; Pal, A.; Debnath, M.; Chakraborty, A.; Pal, S.; Banerjee, S.; Pal, A.; Ghosh, N.; Karmakar, U.; Samanta, R.

10.1101/2022.01.29.478287 — genomics — Posted on 2022-01-31

87 Virucidal activity and mechanism of action of cetylpyridinium chloride against SARS-CoV-2

Okamoto, N.; Saito, A.; Okabayashi, T.; Komine, A.

10.1101/2022.01.27.477964 — microbiology — Posted on 2022-01-31

88 Differences in the gut permeability marker levels, and abundance and nuclear antigen reactivity of fecal immunoglobulin A (IgA) subclasses in systemic lupus erythematosus patients and healthy controls

Gudi, R.; Kamen, D.; Vasu, C.

10.1101/2022.01.26.477918 — immunology — Posted on 2022-01-31

89 Heightened NLRP3 inflammasome activation is associated with aging and CMML diseases severity

Andina, N.; de Meuron, L.; Schnegg-Kaufmann, A. S.; Ansermet, C.; Bomaci, G.; Keller, N.; Porret, N. A.; Angelillo-Scherrer, A.; Bonadies, N.; Allam, R.

10.1101/2022.01.27.477992 — immunology — Posted on 2022-01-31

90 High Frequencies of PD-1+TIM3+TIGIT+CTLA4+ Functionally Exhausted SARS-CoV-2-Specific CD4+ and CD8+ T Cells Associated with Severe Disease in Critically ill COVID-19 Patients

Coulon, P.-G. A.; Prakash, S.; Dhanushkodi, N. R.; Srivastava, R.; Zayou, L.; Tifrea, D. F.; Edwards, R. A.; Figueroa, C. J.; Schubl, S. D.; Hsieh, L.; Nesburn, A. B.; Kuppermann, B. D.; BAHRAOUI, E.; Vahed, H.; Gil, D.; Jones, T. M.; Ulmer, J. B.; BENMOHAMED, L.

10.1101/2022.01.30.478343 — immunology — Posted on 2022-01-31

91 Neural correlates of perceived emotions in human insula and amygdala

Zhang, Y.; Zhou, W.; Huang, J.; Hong, B.; Wang, X.

10.1101/2022.01.29.477631 — neuroscience — Posted on 2022-01-31

92 An actionable map of arm and hand muscle responses to electrical stimulation of the dorsal cervical spinal cord in humans

McIntosh, J. R.; Joiner, E. F.; Goldberg, J. L.; Murray, L. M.; Yasin, B.; Mendiratta, A.; Karceski, S. C.; Thuet, E.; Modik, O.; Shelkov, E.; Mandigo, C.; Riew, K. D.; Harel, N. Y.; Virk, M. S.; Carmel, J. B.

10.1101/2022.01.29.478182 — neuroscience — Posted on 2022-01-31

93 Vamos en bici: Study protocol of an investigation of cognitive and neural changes following language training, physical exercise training, or a combination of both

Wenger, E.; Duezel, S.; Polk, S. E.; Bodammer, N. C.; Misgeld, C.; Porst, J.; Wolfarth, B.; Kuehn, S.; Lindenberger, U.

10.1101/2022.01.30.478181 — neuroscience — Posted on 2022-01-31

94 A critical test of deep convolutional neural networks ability to capture recurrent processing in the brain using visual masking

Loke, J. L.; Seijdel, N.; Snoek, L.; van der Meer, M.; van de Klundert, R.; Quispel, E.; Cappaert, N.; Scholte, H. S.

10.1101/2022.01.30.478404 — neuroscience — Posted on 2022-01-31

95 Reduction of layer 5 mediated long-range cortical communication by antipsychotic drugs

Heindorf, M.; Keller, G. B.

10.1101/2022.01.31.478462 — neuroscience — Posted on 2022-01-31

96 Enrichment of specific GABAergic neuronal types in the mouse perirhinal cortex

Nigro, M. J.; Kjelsberg, K.; Convertino, L.; NAIR, R. R.; Witter, M.

10.1101/2022.01.30.478360 — neuroscience — Posted on 2022-01-31

97 Differences between Omicron SARS-CoV-2 RBD and other variants in their ability to interact with cell receptors and monoclonal antibodies

Correa Giron, C.; Laaksonen, A.; Barroso da Silva, F. L.

10.1101/2022.01.29.478316 — biophysics — Posted on 2022-01-31

98 Analysis of receptors responsible for the dysfunction of the human immune system by different viral infections

Ivanov, S. M.; Tarasova, O. A.; Poroikov, V. V.

10.1101/2022.01.26.477819 — bioinformatics — Posted on 2022-01-31

99 In silico analysis of predicted differential MHC binding and CD8+ T-cell immune escape of SARS-CoV-2 B.1.1.529 variant mutant epitopes

Riesgo-Ferreiro, P.; Ranganath, G.; Bukur, T.; Sorn, P.; Rosler, T.; Schrors, B.; Lower, M.

10.1101/2022.01.31.478157 — bioinformatics — Posted on 2022-01-31

100 Investigating the performance of deep learning methods for Hi-C resolution improvement

Murtaza, G.; Jain, A.; Hughes, M.; Varatharajan, T.; Singh, R.

10.1101/2022.01.27.477975 — bioinformatics — Posted on 2022-01-31

101 The predictive value of double-stranded RNA for A-to-I editing detection

Eran, A.; Shur, G.; Tamir, Y.

10.1101/2022.01.29.478304 — bioinformatics — Posted on 2022-01-31

102 HOW 1 CONCERNING IS A SARS-COV-2 VARIANT OF2 CONCERN? COMPUTATIONAL PREDICTIONS AND3 THE VARIANTS LABELING SYSTEM.

Ashoor, D.; Marzouq, M.; Trabelsi, K.; Chlif, S.; Abotalib, N.; Ben Khalaf, N.; Ramadan, A.; FATHALLAH, D. M.

10.1101/2022.01.31.478425 — molecular biology — Posted on 2022-01-31

103 Visible blue light inactivates SARS-CoV-2 variants and inhibits Delta replication in differentiated human airway epithelia

Kocher, J.; Arwood, L.; Roberts, R.; Henson, I.; Annas, A.; Emerson, D.; Stasko, N.; Fulcher, M. L.; Brotton, M.; Randell, S. H.; Cockrell, A.

10.1101/2022.01.25.477616 — microbiology — Posted on 2022-01-31

104 Omicron-specific mRNA vaccine induced potent neutralizing antibody against Omicron but not other SARS-CoV-2 variants

Lee, I.-J.; Sun, C.-P.; Wu, P.-Y.; Lan, Y.-H.; Wang, I.-H.; Liu, W.-C.; Tseng, S.-C.; Tsung, S.-I.; Chou, Y.-C.; Kumari, M.; Chang, Y.-W.; Chen, H.-F.; Lin, Y.-S.; Chen, T. -Y.; Chiu, C.-W.; Hsieh, C.-H.; Chuang, C.-Y.; Lin, C.-C.; Cheng, C.-M.; Lin, H.-T.; Chen, W.-Y.; Chiang, P.-C.; Lee, C.-C.; Liao, J. C.; Wu, H.-C.; Tao, M.-H.

10.1101/2022.01.31.478406 — microbiology — Posted on 2022-01-31

105 Susceptibility of wild canids to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Porter, S. M.; Hartwig, A. E.; Bielefeldt-Ohmann, H.; Bosco-Lauth, A. M.; Root, J. J.

10.1101/2022.01.27.478082 — microbiology — Posted on 2022-01-31

106 Combating the SARS-CoV-2 Omicron variant with non-Omicron neutralizing antibodies

Wang, Y.; Zhang, X.; Liu, J.; Wang, Y.; Zhan, W.; Liu, M.; Zhang, M.; Wang, Q.; Liu, Q.; Zhu, T.-Y.; Wen, Y.; Chen, Z.; Zhao, J.; Wu, F.; Sun, L.; Huang, J.

10.1101/2022.01.30.478305 — microbiology — Posted on 2022-01-31

107 An intranasal lentiviral booster broadens immune recognition of SARS-CoV-2 variants and reinforces the waning mRNA vaccine-induced immunity that it targets to lung mucosa

Vesin, B.; Lopez, J.; Noirat, A.; Authie, P.; Fert, I.; Le Chevalier, F.; Moncoq, F.; Nemirov, K.; Blanc, C.; Planchais, C.; Mouquet, H.; Guinet, F.; Hardy, D.; Gerke, C.; Anna, F.; Bourgine, M.; MAJLESSI, L.; Charneau, P.

10.1101/2022.01.30.478159 — immunology — Posted on 2022-01-31

108 SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection

Greaney, A. M.; Raredon, M. S. B.; Kochugaeva, M. P.; Niklason, L. E.; Levchenko, A.

10.1101/2022.01.29.478335 — systems biology — Posted on 2022-01-31

109 Power analysis for spatial omics

Baker, E. A. G.; Schapiro, D.; Dumitrascu, B.; Vickovic, S.; Regev, A.

10.1101/2022.01.26.477748 — bioinformatics — Posted on 2022-01-31

110 A single-cell atlas of de novo β-cell regeneration reveals the contribution of hybrid β/δ cells to diabetes recovery in zebrafish

Singh, S. P.; Chawla, P.; Hnatiuk, A.; Kamel, M.; Delgadillo Silva, L. F.; Spanjaard, B.; Eski, S. E.; Janjuha, S.; Olivares Chauvet, P.; Kayisoglu, O.; Rost, F.; Blasche, J.; Krankel, A.; Petzold, A.; Kurth, T.; Reinhardt, S.; Junker, J. P.; Ninov, N.

10.1101/2021.06.24.449704 — developmental biology — Posted on 2022-01-31

111 Membrane-assisted assembly and selective autophagy of enteroviruses

Dahmane, S.; Kerviel, A.; Morado, D. R.; Shankar, K.; Ahlman, B.; Lazarou, M.; Altan-Bonnet, N.; Carlson, L.-A.

10.1101/2021.10.06.463375 — microbiology — Posted on 2022-01-31

112 Real-time neurofeedback to alter interpretations of a naturalistic narrative

Mennen, A. C.; Nastase, S. A.; Yeshurun, Y.; Hasson, U.; Norman, K. A.

10.1101/2022.01.30.478388 — neuroscience — Posted on 2022-01-31

113 Echolocation reverses information flow in a cortical vocalization network

García-Rosales, F.; Lopez-Jury, L.; Gonzalez-Palomares, E.; Wetekam, J.; Cabral-Calderin, Y.; Kiai, A.; Kössl, M.; Hechavarria, J. C.

10.1101/2021.03.15.435430 — neuroscience — Posted on 2022-01-31

114 Evidence for widespread alterations in cortical microstructure after 32 hours of sleep deprivation

Voldsbekk, I.; Bjornerud, A.; Groote, I. R.; Zak, N.; Roelfs, D.; Maximov, I. I.; Geier, O.; Due-Tonnessen, P.; Boen, E.; Kuiper, Y.; Lokken, L.-L.; Stromstad, M.; Blakstvedt, T. Y.; Bjorvatn, B.; Malt, U. F.; Westlye, L. T.; Elvsashagen, T.; Grydeland, H.

10.1101/2021.06.22.449439 — neuroscience — Posted on 2022-01-31

115 URMC-099 Prophylaxis Prevents Hippocampal Vascular Vulnerability and Synaptic Damage in an Orthopedic Model of Delirium Superimposed on Dementia

Miller-Rhodes, P.; Li, H.; Velagapudi, R.; Terrando, N.; Gelbard, H. A.

10.1101/2021.10.04.463042 — neuroscience — Posted on 2022-01-31

116 Low-level Action Schemas Support Gaze Guidance Behavior for Action Planning and Execution in Novel Tasks

Keshava, A.; Nezami, F. N.; Neumann, H.; Izdebski, K.; Schueler, T.; Koenig, P.

10.1101/2021.01.29.428782 — neuroscience — Posted on 2022-01-31

117 Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster

Crain, A. T.; Klusza, S.; Armstrong, R. L.; Santa Rosa, P.; Temple, B. R. S.; Strahl, B. D.; McKay, D. J.; Matera, A. G.; Duronio, R. J.

10.1101/2022.01.30.478405 — genetics — Posted on 2022-01-31

118 Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks

Myren-Svelstad, S.; Jamali, A.; Ophus, S. S.; Ostenrath, A. M.; Mutlu, A. K.; Hoffshagen, H. H.; Hotz, A. L.; Neuhauss, S. C. F.; Jurisch-Yaksi, N.; Yaksi, E.

10.1101/2022.01.30.478306 — neuroscience — Posted on 2022-01-31

119 Proximity of astrocyte leaflets to the synapse determines memory strength

Badia-Soteras, A.; Heistek, T. S.; Kater, M.; Negrean, A.; Mansvelder, H. S.; Khakh, B.; Min, R.; Smit, A.; Verheijen, M.

10.1101/2022.01.30.478393 — neuroscience — Posted on 2022-01-31

120 Stress resilience is established during development and is regulated by complement factors

Swaminathan, A.; Gliksberg, M.; Anbalagan, S.; Wigoda, N.; Levkowitz, G.

10.1101/2022.01.31.478444 — neuroscience — Posted on 2022-01-31

121 Genomic analyses identify key molecules and significant signaling pathways in AZIN1 regulated prostate cancer cells

Chang, T.; Gu, H.; Liu, J.

10.1101/2022.01.29.478331 — bioinformatics — Posted on 2022-01-31

122 Single-nuclei transcriptomics of dog hippocampus reveals the distinct cellular mechanism of domestication

Zhou, Q.-J.; Liu, X.; Zhang, L.; Wang, R.; Yin, T.; Li, X.; Li, G.; He, Y.; Ding, Z.; Ma, P.; Wang, S.-Z.; Mao, B.; Zhang, S.; Wang, G.-D.

10.1101/2022.01.29.478120 — evolutionary biology — Posted on 2022-01-31

123 Avoidance of premature splicing in short introns explains the polypyrimidine tract

Yildirim, B.; Vogl, C.

10.1101/2022.01.29.478184 — evolutionary biology — Posted on 2022-01-31

124 Rapidly evolving viral motifs target biophysically constrained binding pockets of host proteins

Shuler, G.; Hagai, T.

10.1101/2022.01.29.478279 — microbiology — Posted on 2022-01-31

125 Chronic brain functional ultrasound imaging in freely moving rodents performing cognitive tasks

El Hady, A.; Takahashi, D. Y.; Sun, R.; Boyd-Meredith, T.; Zhang, Y.; Charles, A.; Brody, C.

10.1101/2022.01.29.478327 — neuroscience — Posted on 2022-01-31

126 Cell Centred Finite Element Model for Intestinal Organoids Shape Analysis: From tissue architecture to mechanics

laussu, j.; michel, d.; segonds, s.; marguet, s.; barreau, f.; hamel, d.; mas, e.; ferrand, a.; bugarin, f.

10.1101/2022.01.27.477994 — biophysics — Posted on 2022-01-31

127 Differentiation signals from glia are fine-tuned to set neuronal numbers during development

Prasad, A. R.; Lago-Baldaia, I.; Bostock, M. P.; Housseini, Z.; Fernandes, V. M.

10.1101/2021.12.13.472383 — neuroscience — Posted on 2022-01-31

128 A snapshot of the root phenotyping landscape in 2021

Delory, B. M.; Hernandez-Soriano, M. C.; Wacker, T. S.; Dimitrova, A.; Ding, Y.; Greeley, L. A.; Ng, J. L. P.; Mesa-Marin, J.; Xie, L.; Zheng, C.; York, L. M.

10.1101/2022.01.28.478001 — scientific communication and education — Posted on 2022-01-31

129 The adapted Activity-By-Contact model for enhancer-gene assignment and its application to single-cell data

Hecker, D.; Behjati Ardakani, F.; Schulz, M. H.

10.1101/2022.01.28.478202 — bioinformatics — Posted on 2022-01-31

130 Tunable Cellular Localization and Extensive Cytoskeleton-Interplay of Reflectins

Song, J.; Chuanyang, L.; Li, B.; Liu, L.; Zeng, L.; Ye, Z.; Wu, W.; Hu, B.

10.1101/2021.08.23.457345 — cell biology — Posted on 2022-01-31

131 Cell wall's mesoscale organization in Deinococcus radiodurans

Farci, D.; Haniewicz, P.; Piano, D.

10.1101/2022.01.29.478271 — microbiology — Posted on 2022-01-31

132 Evolution of chlorhexidine susceptibility and of the EfrEF operon among Enterococcus faecalis from diverse environments, clones and time spans

Pereira, A. P.; Antunes, P.; Willems, R. J. L.; Corander, J.; Coque, T. M.; Peixe, L.; Freitas, A. R.; Novais, C.

10.1101/2022.01.27.478125 — microbiology — Posted on 2022-01-31

133 Staphylococcus aureus prophages are gatekeepers of exogenous lipid utilization to control membrane flexibility and bacterial fitness

Gloux, K.; Zhou, B.; Pathania, A.; Pant, D.; Gaudu, P.; Trieu-Cuot, P.; Gruss, A.

10.1101/2022.01.27.478126 — microbiology — Posted on 2022-01-31

134 Structural basis for regulation of a tripartite toxin-antitoxin system by dual phosphorylation

Baerentsen, R. L.; Nielsen, S. V.; Lyngso, J.; Bisiak, F.; Pedersen, J. S.; Gerdes, K.; Sorensen, M. A.; Brodersen, D.

10.1101/2022.01.28.478185 — microbiology — Posted on 2022-01-31

135 Rhythmic Cilium in SCN Neuron is a Gatekeeper for the Intrinsic Circadian Clock

Hai-Qing, T.; Sen, L.; Yu-Ling, X.; Yu-Cheng, Z.; Xiao-Xiao, J.; Guang-Ping, S.; Min, W.; Zeng-Qing, S.; Huai-Bin, H.; Pei-Yao, L.; Li-Yun, L.; Jin-Feng, Y.; Xiao-Lin, S.; Jia-Ning, L.; Qiu-Ying, H.; Kai, W.; Tao, Z.; Tao, Z.; Ai-ling, L.; Xue-Min, Z.; Hui-Yan, L.

10.1101/2022.01.26.477948 — neuroscience — Posted on 2022-01-31

136 Dynamic human liver proteome atlas reveals functional insights into disease pathways

Mann, M.; Niu, L.; Geyer, P.; Gupta, R.; Santos, A.; Meier, F.; Doll, S.; Wewer Albrechtsen, N. J.; Klein, S.; Ortiz, C.; Uschner, F. E.; Schierwagen, R.; Trebicka, J.

10.1101/2022.01.28.478194 — systems biology — Posted on 2022-01-31

137 A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer

Grubb, T. M.; Maganti, S.; Krill-Burger, J. M.; Fraser, C.; Stransky, L.; Radivoyevitch, T.; Sarosiek, K.; Vazquez, F.; Kaelin, W. G.; Chakraborty, A.

10.1101/2022.01.29.478337 — cancer biology — Posted on 2022-01-31

138 RNA induces unique tau strains and stabilizes Alzheimer disease seeds

Zwierzchowski-Zarate, A.; Kashmer, O. M.; Collazo-Lopez, J. E.; White, C. L.; Diamond, M. I.

10.1101/2022.01.29.478315 — biochemistry — Posted on 2022-01-31

139 Matrix topology guides collective cell migration in vivo

Soans, K. G.; Ramos, A. P.; Sidhaye, J.; Krishna, A.; Solomatina, A.; Hoffmann, K. B.; Schluessler, R.; Guck, J.; Sbalzarini, I. F.; Modes, C. D.; Norden, C.

10.1101/2022.01.31.478442 — developmental biology — Posted on 2022-01-31

140 NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and endosomal microferritinophagy

Ohshima, T.; Yamamoto, H.; Sakamaki, Y.; Saito, C.; Mizushima, N.

10.1101/2022.01.31.478434 — cell biology — Posted on 2022-01-31

141 MUCOSECRETORY LUNG DISEASE: DIFFERENT ASSEMBLIES OF JAG1 AND JAG2 DETERMINE TRACHEOBRONCHIAL CELL FATE

Reynolds, S. D.; Hill, C. L.; Alsudayri, A.; Lallier, S. W.; Wijeratne, S.; Tan, Z. H.; Chiang, T.; Cormet-Boyaka, E.

10.1101/2022.01.29.478334 — cell biology — Posted on 2022-01-31

142 Morphology of immatures of the thelytokous ant, Monomorium triviale Wheeler (Formicidae: Myrmicinae: Solenopsidini) with descriptions of the extraordinary last-instar queen larvae

Idogawa, N.; Gotoh, A.; Dobata, S.

10.1101/2021.11.07.467650 — zoology — Posted on 2022-01-31

143 LinkExplorer: Predicting, explaining and exploring links in large biomedical knowledge graphs

Ott, S.; Barbosa-Silva, A.; Samwald, M.

10.1101/2022.01.09.475537 — bioinformatics — Posted on 2022-01-31

144 GBRAP: a tool to retrieve, parse and analyze GenBank files of viral and bacterial species

Vischioni, C.; Giaccone, V.; Catellani, P.; Alberghini, L.; Scapin, R. M.; Taccioli, C.

10.1101/2021.09.21.461110 — bioinformatics — Posted on 2022-01-31

145 A Phase-separating Thiol-ene Photoresin for Volumetric Bioprinting of Macroporous Hydrogels

Muller, M. Z.; Style, R. W.; Muller, R.; Qin, X.-H.

10.1101/2022.01.29.478338 — bioengineering — Posted on 2022-01-31

146 Scaphoideus titanus Ball feeding behaviour on three grapevine cultivars with different susceptibilities to Flavescence doree

Ripamonti, M.; Maron, F.; Cornara, D.; Marzachi, C.; Fereres, A.; Bosco, D.

10.1101/2021.11.25.470030 — animal behavior and cognition — Posted on 2022-01-31

147 Waves and currents decrease the available space in a salmon cage

Johannesen, A.; Patursson, O.; Kristmundsson, J.; Dam, S. P.; Mulelid, M.; Klebert, P.

10.1101/2021.07.23.453560 — animal behavior and cognition — Posted on 2022-01-31

148 Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts

Nicks, A. M.; Holman, S. R.; Chan, A. Y.; Tsang, M.; Young, P. E.; Humphreys, D. T.; Naqvi, N.; Husain, A.; Li, M.; Smith, N. J.; Iismaa, S. E.; Graham, R. M.

10.1101/2021.09.30.462562 — cell biology — Posted on 2022-01-31

149 An NMR fingerprint matching approach for the identification and structural re-evaluation of Pseudomonas lipopeptides.

De Roo, V.; Verleysen, Y.; Kovacs, B.; De Vleeschouwer, M.; Girard, L.; Hofte, M.; De Mot, R.; Madder, A.; Geudens, N.; Martins, J. C.

10.1101/2022.01.07.475420 — microbiology — Posted on 2022-01-31

150 OViTAD: Optimized Vision Transformer to Predict Various Stages of Alzheimer's Disease Using Resting-State fMRI and Structural MRI Data

Sarraf, S.; Sarraf, A.; DeSouza, D. D.; Anderson, J. A. E.; Kabia, M.; ADNI, T. A. D. N. I.

10.1101/2021.11.27.470184 — neuroscience — Posted on 2022-01-31

151 Reversal Learning Phenotypes are Linked with Novel Genetic Loci in Diversity Outbred Mice

Bagley, J. R.; Bailey, L. S.; Gagnon, L. H.; He, H.; Philip, V. M.; Reinholdt, L. G.; Tarantino, L. M.; Chesler, E. J.; Jentsch, J. D.

10.1101/2022.01.29.478259 — genetics — Posted on 2022-01-31

152 Protein-protein interactions on membrane surfaces analysed using pull-downs with supported bilayers on silica beads

Andhare, D.; Khurana, H.; Pucadyil, T.

10.1101/2021.12.06.471516 — biochemistry — Posted on 2022-01-30

153 Forced proximity promotes the formation of enduring cooperative relationships in vampire bats

Razik, I.; Brown, B. K. G.; Carter, G. G.

10.1101/2022.01.30.478382 — animal behavior and cognition — Posted on 2022-01-31

154 Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics

The COVID Moonshot Initiative, ; Achdout, H.; Aimon, A.; Bar-David, E.; Barr, H.; Ben-Shmuel, A.; Bennett, J.; Bilenko, V. A.; Bilenko, V. A.; Boby, M. L.; Borden, B.; Bowman, G. R.; Brun, J.; BVNBS, S.; Calmiano, M.; Carbery, A.; Carney, D.; Cattermole, E.; Chang, E.; Chernyshenko, E.; Chodera, J. D.; Clyde, A.; Coffland, J. E.; Cohen, G.; Cole, J.; Contini, A.; Cox, L.; Cvitkovic, M.; Dias, A.; Donckers, K.; Dotson, D. L.; Douangamath, A.; Duberstein, S.; Dudgeon, T.; Dunnett, L.; Eastman, P. K.; Erez, N.; Eyermann, C. J.; Fairhead, M.; Fate, G.; Fearon, D.; Fedorov, O.; Ferla, M.; Fernande

10.1101/2020.10.29.339317 — biochemistry — Posted on 2022-01-30

155 Non-identifiability and the Blessings of Misspecification in Models of Molecular Fitness and Phylogeny

Weinstein, E. N.; Amin, A. N.; Frazer, J.; Marks, D.

10.1101/2022.01.29.478324 — evolutionary biology — Posted on 2022-01-30

156 ACCURATE DECODING OF THE SPINAL CORD OUTPUT IN HUMANS WITH IMPLANTED HIGH-DENSITY ELECTRODE ARRAYS

Muceli, S.; Poppendieck, W.; Holobar, A.; Gandevia, S.; Liebetanz, D.; Farina, D.

10.1101/2022.01.29.478247 — neuroscience — Posted on 2022-01-30

157 Evolution of neural activity in circuits bridging sensory and abstract knowledge

Mastrogiuseppe, F.; Hiratani, N.; Latham, P.

10.1101/2022.01.29.478317 — neuroscience — Posted on 2022-01-30

158 Membrane contact probability: an essential and predictive character for the structural and functional studies of membrane proteins

Wang, L.; Zhang, J.; Wang, D.; Song, C.

10.1101/2021.01.17.426988 — biophysics — Posted on 2022-01-30

159 Capturing non-local through-bond effects in molecular mechanics force fields I: Fragmenting molecules for quantum chemical torsion scans

Stern, C. D.; Bayly, C. I.; Smith, D. G. A.; Fass, J.; Wang, L.-P.; Mobley, D. L.; Chodera, J. D.

10.1101/2020.08.27.270934 — biophysics — Posted on 2022-01-30

160 Systemic impact of the expression of the mitochondrial alternative oxidase on Drosophila development

Camargo, A. F.; Saari, S.; Garcia, G. S.; Chioda, M. M.; Othonicar, M. F.; Martins, A. A.; Hayashi, G.; ten Hoeve, J.; Jacobs, H. T.; Pinheiro, D. G.; Dufour, E.; Oliveira, M. T.

10.1101/2021.09.24.461559 — biochemistry — Posted on 2022-01-30

161 Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence

Mohammadi, S.; Yang, L.; Herrera-Alvarez, S.; Rodriguez-Ordonez, M. d. P.; Zhang, K.; Storz, J.; Dobler, S.; Crawford, A. J.; Andolfatto, P.

10.1101/2021.11.29.470343 — evolutionary biology — Posted on 2022-01-30

162 X chromosomes show relaxed selection and complete somatic dosage compensation across Timema stick insect species

Parker, D. J.; Jaron, K. S.; Dumas, Z.; Robinson-Rechavi, M.; Schwander, T.

10.1101/2021.11.28.470265 — evolutionary biology — Posted on 2022-01-30

163 Accurate Segmentation of Bacterial Cells using Synthetic Training Data

Hardo, G.; Noka, M.; Bakshi, S.

10.1101/2021.07.21.453284 — microbiology — Posted on 2022-01-30

164 Peripheral Nerve Magnetoneurography with Optically Pumped Magnetometers

Bu, Y.; Prince, J.; Schwindt, P.; Rao, R.; Zeng, X.; Huang, M.; Baum, E.; Kimball, D.; Shah, V.; Borna, A.; Lerman, I.

10.1101/2021.05.18.444539 — neuroscience — Posted on 2022-01-30

165 Links between memory, synapses, amyloid-beta, tau and microglial changes after tau pathology induction by Alzheimer's brain inoculation in amyloid-beta-plaque bearing mice

Lam, S.; Herard, A. S.; Boluda, S.; Petit, F.; Eddarkaoui, S.; Cambon, K.; Picq, J. L.; Buee, L.; Duyckaerts, C.; Haik, S.; Dhenain, M.

10.1101/2021.04.06.438654 — neuroscience — Posted on 2022-01-30

166 Neuronal membrane proteasomes homeostatically regulate neural circuit activity in vivo and are required for learning-induced behavioral plasticity

He, H.-y.; Ramachandran, K.; McLain, N.; Faulkner, R.; Ahsan, A.; Bera, R.; Margolis, S. S.; Cline, H. T.

10.1101/2022.01.29.478314 — neuroscience — Posted on 2022-01-30

167 Cannabinoid receptor 1 is required for neurodevelopment of striosome-dendron bouquets

Crittenden, J. R.; Yoshida, T.; Venu, S.; Mahar, A.; Graybiel, A. M.

10.1101/2022.01.29.478320 — neuroscience — Posted on 2022-01-30

168 Extracellular Matrix Levels Modulate Outgrowths Dynamics in Ovarian Cancer.

Alshehri, S.; Pavlovic, T.; Farsinejad, S.; Behboodi, P.; Quan, L.; Centeno, D.; Kung, D.; Rezler, M.; Lee, W.; Jasinski, P.; Dziabaszewska, E.; Nowak-Markwitz, E.; Kalyon, D.; Wang, S.; Zaborowski, M.; Iwanicki, M.

10.1101/2022.01.30.478322 — cancer biology — Posted on 2022-01-30

169 The genome sequence of Hirschfeldia incana, a species with high photosynthetic light-use efficiency

Garassino, F.; Wijfjes, R. Y.; Boesten, R.; Becker, F. F. M.; Clapero, V.; van den Hatert, I.; Holmer, R.; Schranz, M. E.; Harbinson, J.; de Ridder, D.; Smit, S.; Aarts, M. G. M.

10.1101/2022.01.29.478283 — bioinformatics — Posted on 2022-01-30

170 Establishment of physiologically relevant oxygen gradients in microfluidic organ chips

Grant, J.; Lee, E.; Almeida, M.; Kim, S.; LoGrande, N.; Goyal, G.; Sesay, A. M.; Breault, D. T.; Prantil-Baun, R.; Ingber, D. E.

10.1101/2022.01.29.478323 — bioengineering — Posted on 2022-01-30

171 Group dynamics and habitat use of the Giant Otter, Pteronura brasiliensis (Zimmermann, 1780), in seasonally flooded forest in the Araguaia River, Central Brazil: A 10-years study.

Leles, B.; Georgiadis, G.; Susana, T. C.; Kaczmarek, N.; Brandao, R. A.; Campello, S.

10.1101/2022.01.30.478386 — animal behavior and cognition — Posted on 2022-01-30

172 Spatial and Temporal Regulation of Parent-of-Origin Allelic Expression in the Endosperm

van Ekelenburg, Y. S.; Hornslien, K. S.; Hautegem, T. V.; Fendrych, M.; Isterdael, G. V.; Bjerkan, K. N.; Miller, J. R.; Nowack, M. K.; Grini, P. E.

10.1101/2022.01.29.478178 — genetics — Posted on 2022-01-30

173 Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus

Schott, B. H.; Wang, L.; Zhu, X.; Harding, A. T.; Ko, E. R.; Bourgeois, J. S.; Washington, E. J.; Burke, T. J.; Anderson, J.; Bergstrom, E.; Gardener, Z.; Paterson, S.; Brennan, R. G.; Chiu, C.; McClain, M. T.; Woods, C. W.; Gregory, S. G.; Heaton, N. S.; Ko, D. C.

10.1101/2022.01.30.478319 — genetics — Posted on 2022-01-30

174 Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death

Chang, S. C.; Gopal, P.; Lim, S.; Wei, X.; Mangadu, R.; Smith, J.; Ng, S.; Gindy, M.; Phan, U.; Henry, B.; Partridge, A. W.

10.1101/2022.01.29.478266 — cell biology — Posted on 2022-01-30

175 Thyroid hormones deficiency impairs male germ cell development: a cross talk between hypothalamic-pituitary-thyroid, and - gonadal axes in zebrafish

Rodrigues, M. S.; Tovo-Neto, A.; da Rosa, I. F.; Doretto, L.; Pourmohammad, H.; Habibi, H.; Nobrega, R. H.

10.1101/2022.01.30.478377 — cell biology — Posted on 2022-01-30

176 A lymphatic-stem cell interactome regulates intestinal stem cell activity

Niec, R.; Chu, T.; Gur-Cohen, S.; Schernthanner, M.; Hidalgo, L.; Pasolli, H. A.; Kataru, R.; Mehrara, B.; Pe'er, D.; Fuchs, E.

10.1101/2022.01.29.478341 — cell biology — Posted on 2022-01-30

177 Condensation of a nuclear mRNA export factor regulates mRNA transport during stress

Heinrich, S.; Hondele, M.; Marchand, D.; Derrer, C. P.; Zedan, M.; Oswald, A.; Uliana, F.; Mancini, R.; Grunwald, D.; Weis, K.

10.1101/2022.01.30.478372 — cell biology — Posted on 2022-01-30

178 A flexible network of lipid droplet associated proteins support embryonic integrity of C. elegans

Cao, Z.; Fung, C. W.; Mak, H. Y.

10.1101/2022.01.30.478363 — cell biology — Posted on 2022-01-30

179 Pinpointing the tumor-specific T-cells via TCR clusters

Goncharov, M.; Bryushkova, E. A.; Sharayev, N. I.; Skatova, V. D.; Baryshnikova, A. M.; Sharonov, G. V.; Samoylenko, I. V.; Demidov, L. V.; Chudakov, D. M.; Serebrovskaya, E. O.

10.1101/2022.01.30.478375 — immunology — Posted on 2022-01-30

180 ScRNA-seq Expression of APOC2 and IFI27 Identifies Four Families of Alveolar Macrophage Superclusters in Cystic Fibrosis and Healthy BALF

Li, X.; Kolling, F.; Aridgides, D.; Mellinger, D.; Ashare, A.; Jakubzick, C.

10.1101/2022.01.30.478325 — immunology — Posted on 2022-01-30

181 Multiphasic hepatitis B virus kinetic patterns in humanized chimeric mice can be explained via stochastic agent-based modeling of intracellular virion production cycles

Hailegiorgis, A.; Ishida, Y.; Collier, N.; Imamura, M.; Shi, Z.; Reinharz, V.; Tsuge, M.; Barash, D.; Hiraga, N.; Yokomichi, H.; Tateno, C.; Ozik, J.; Uprichard, S. L.; Chayama, K.; Dahari, H.

10.1101/2022.01.30.478385 — systems biology — Posted on 2022-01-30

182 The grapevine leaves that are (or were) not: constraints on leaf development and choosing to see what seemingly is not

Chitwood, D. H.; Mullins, J.

10.1101/2022.01.29.478336 — plant biology — Posted on 2022-01-30

183 LKB1 acts as a critical brake for the glucagon-mediated fasting response

Acevedo-Acevedo, S.; Stefkovich, M. L.; Kang, S. W. S.; Cunningham, R. P.; Cultraro, C. M.; Porat-Shliom, N.

10.1101/2022.01.29.478228 — physiology — Posted on 2022-01-30

184 Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

Yagi, H.; Akazawa, H.; Liu, Q.; Yamamoto, K.; Nawata, K.; Saga-Kamo, A.; Umei, M.; Kadowaki, H.; Matsuoka, R.; Shindo, A.; Toko, H.; Takeda, N.; Ando, M.; Yamauchi, H.; Takeda, N.; Fini, M. A.; Ono, M.; Komuro, I.

10.1101/2022.01.30.478356 — pathology — Posted on 2022-01-30

185 Liver Protein Expression in NASH Mice on a High-Fat Diet

Varani, J.; McClintock, S. D.; Knibbs, R. N.; Harber, I.; Zeidan, D.; Jawad-Makki, M. A. H.; Aslam, M. N.

10.1101/2022.01.29.478332 — molecular biology — Posted on 2022-01-30

186 Meta-analysis reveals the global picture of antibiotic resistance gene prevalence across environments

Abramova, A.; Berendonk, T. U.; Bengtsson-Palme, J.

10.1101/2022.01.29.478248 — microbiology — Posted on 2022-01-30

187 Hedgehogs are the major amplifying hosts of severe fever with thrombocytopenia syndrome virus

Zheng, A.; Jiang, J.; Zhao, C.; Zhang, X.; Hao, J.; Ye, L.; Lawrence, K.; Lu, Y.; Du, C.; Si, X.; Xu, H.; Yang, Q.; Xia, Q.; Yu, G.; Yuan, F.

10.1101/2022.01.30.478379 — microbiology — Posted on 2022-01-30

188 An Acyclic Phosphonate Prodrug of HPMPC is Effective Against VZV in Skin Organ Culture and Mice

Lloyd, M. G.; Liu, D.; Lyu, J.; Fan, J.; Overhulse, J.; Kashemirov, B. A.; Prichard, M. N.; McKenna, C. E.; Moffat, J. F.

10.1101/2022.01.30.478368 — microbiology — Posted on 2022-01-30

189 mTOR-regulated Mitochondrial Metabolism Limits Mycobacterium-induced Cytotoxicity

Pagan, A. J.; Lee, L. J.; Edwards-Hicks, J.; Moens, C. B.; Tobin, D. M.; Busch-Nentwich, E. M.; Pearce, E. L.; Ramakrishnan, L.

10.1101/2022.01.30.478369 — immunology — Posted on 2022-01-30

190 Development of 3D breast cancer models with human T cells expressing engineered MAIT cell receptors

Dey, M.; Kim, M. H.; Nagamine, M.; Karhan, E.; Kozhaya, L.; Dogan, M.; Unutmaz, D.; Ozbolat, I. T.

10.1101/2022.01.29.478309 — immunology — Posted on 2022-01-30

191 Clemizole and Trazodone are Effective Antiseizure Treatments in a Zebrafish Model of STXBP1 Disorder

Moog, M.; Baraban, S. C.

10.1101/2022.01.30.478390 — neuroscience — Posted on 2022-01-30

192 The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila

Rosell, A. L.; Paglione, M.; Gilley, J.; Kocia, M.; Gasparrini, M.; Cialabrini, L.; Raffaelli, N.; Angeletti, C.; Orsomando, G.; Coleman, M.; Loreto, A.; Neukomm, L.

10.1101/2022.01.30.478002 — neuroscience — Posted on 2022-01-30

193 Pectin cell wall remodeling through PLL12 and callose deposition through polar CALS7 are necessary for long-distance phloem transport

Kalmbach, L.; Bourdon, M.; Heo, J.-o.; Otero, S.; Blob, B.; Helariutta, Y.

10.1101/2022.01.29.478312 — plant biology — Posted on 2022-01-30

194 A Phase-separating Thiol-ene Photoresin for Volumetric Bioprinting of Macroporous Hydrogels

Muller, M. Z.; Style, R. W.; Muller, R.; Qin, X.-H.

10.1101/2022.01.29.478338 — bioengineering — Posted on 2022-01-30

195 Oxygen availability drives blood traits and the cell number-size tradeoff across Andean hummingbirds

Williamson, J. L.; Linck, E. B.; Bautista, E.; Smiley, A.; McGuire, J. A.; Dudley, R.; Witt, C. C.

10.1101/2022.01.18.476833 — evolutionary biology — Posted on 2022-01-30

196 The Evolutionary History of Small RNAs in the Solanaceae

Baldrich, P.; Belanger, S.; Kong, S.; Pokhrel, S.; Tamim, S.; Teng, C.; Schiebout, C.; Gurazada, S. G. R.; Gupta, P.; Patel, P.; Razifard, H.; Nakano, M.; Dusia, A.; Meyers, B. C.; Frank, M.

10.1101/2021.05.26.445884 — plant biology — Posted on 2022-01-30

197 Sex biases in cancer and autoimmune disease incidence are strongly positively correlated with mitochondrial gene expression across human tissues

Crawford, D. R.; Sinha, S.; Nair, N. U.; Ryan, B. M.; Barnholtz-Sloan, J. S.; Mount, S. M.; Erez, A.; Aldape, K.; Castle, P. E.; Rajagopal, P. S.; Day, C.-P.; Schäffer, A. A.; Ruppin, E.

10.1101/2021.09.07.459207 — cancer biology — Posted on 2022-01-30

198 FMSClusterFinder: A new tool for detection and identification of clusters of sequential motifs with varying characteristics inside genomic sequences

Hejazi, M. M.; Golabi, F.; Bahrami, M.; Kahroba, H.; Hejazi, M. S.

10.1101/2022.01.23.474238 — bioinformatics — Posted on 2022-01-30

199 Unsupervised genome-wide cluster analysis: nucleotide sequences of the omicron variant of SARS-CoV-2 are similar to sequences from early 2020

Hahn, G.; Lee, S.; Prokopenko, D.; Novak, T.; Hecker, J.; Khurana, S.; Baden, L. R.; Randolph, A. G.; Weiss, S. T.; Lange, C.

10.1101/2021.12.29.474469 — bioinformatics — Posted on 2022-01-30

200 Improved AlphaFold modeling with implicit experimental information

Terwilliger, T. C.; Poon, B. K.; Afonine, P.; Schlicksup, C. J.; Croll, T. I.; Millan-Nebot, C.; Richardson, J. S.; Read, R. J.; Adams, P. D.

10.1101/2022.01.07.475350 — biochemistry — Posted on 2022-01-30

201 Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

Flynn, J. M.; Samant, N.; Schneider-Nachum, G.; Barkan, D. T.; Yilmaz, N. K.; Schiffer, C. A.; Moquin, S. A.; Dovala, D.; Bolon, D. N. A.

10.1101/2022.01.26.477860 — molecular biology — Posted on 2022-01-30

202 A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type virus and Delta variant

Jiang, L.; Driedonks, T.; Lowman, M.; Jong, W. S.; van den Berg van Saparoea, H. B.; Dhakal, S.; Zhou, R.; Caputo, C.; Littlefield, K.; Sitaris, I.; Chen, M. W.; Lima, G.; Gololobova, O.; Smith, B.; Mahairaki, V.; Richardson, M. R.; Mulka, K. R.; Lane, A. P.; Klein, S. L.; Pekosz, A.; Brayton, C. F.; Mankowski, J.; Luirink, J.; Villano, J. S.; Witwer, K. W.

10.1101/2021.06.28.450181 — immunology — Posted on 2022-01-30

203 Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium

Mehregan, A.; Perez-Conesa, S.; Zhuang, Y.; Elbahnsi, A.; Pasini, D.; Lindahl, E.; Howard, R. J.; Ulens, C.; Delemotte, L.

10.1101/2021.05.28.446179 — biophysics — Posted on 2022-01-30

204 The effects of sequencing depth on the assembly of coding and noncoding transcripts in the human genome

Babarinde, I. A.; Hutchins, A. P.

10.1101/2022.01.30.478357 — bioinformatics — Posted on 2022-01-30

205 Interplay between rule learning and rule switching in a perceptual categorization task

Bouchacourt, F.; Tafazoli, S.; Mattar, M. G.; Buschman, T. J.; Daw, N. D.

10.1101/2022.01.29.478330 — neuroscience — Posted on 2022-01-30

206 Transcription feedback dynamics in the wake of cytoplasmic degradation shutdown

Chappleboim, A.; Joseph-Strauss, D.; Gershon, O.; Friedman, N.

10.1101/2021.12.01.470637 — cell biology — Posted on 2022-01-30

207 Phylogenomic evidence for the Origin of Obligately Anaerobic Anammox Bacteria around the Great Oxidation Event

Liao, T.; Wang, S.; Stueeken, E. E.; Luo, H.

10.1101/2021.07.07.451387 — microbiology — Posted on 2022-01-30

208 Correction of the scientific production: publisher performance evaluation using a dataset of 4844 PubMed retractions.

Toma, C. S.; Padureanu, L.; Toma, B.

10.1101/2022.01.23.477400 — scientific communication and education — Posted on 2022-01-30

209 Accurate estimation of cell-type resolution transcriptome in bulk tissue through matrix completion

Wang, W.; Yao, J.; Wang, Y.; Zhang, C.; Tao, W.; Zou, J.; Ni, T.

10.1101/2021.06.30.450493 — bioinformatics — Posted on 2022-01-29

210 Contrast-enhanced microCT evaluation of degeneration following partial and full width injuries to mouse lumbar intervertebral disc

Walk, R. E.; Moon, H. J.; Tang, S. Y.; Gupta, M. C.

10.1101/2022.01.14.476362 — bioengineering — Posted on 2022-01-29

211 Recruitment and organization of ESCRT-0 and ubiquitinated cargo via condensation

Banjade, S.; Zhu, L.; Jorgensen, J. R.; Suzuki, S. W.; Emr, S. D.

10.1101/2021.08.23.457352 — cell biology — Posted on 2022-01-29

212 Intrinsic excitability mechanisms of neuronal ensemble formation

Alejandre-Garcia, T.; Kim, S.; Perez-Ortega, J. E.; Yuste, R.

10.1101/2020.07.29.223966 — neuroscience — Posted on 2022-01-29

213 Dynamic Cognitive States Predict Individual Variability in Behavior and Modulate with EEG Functional Connectivity during Working Memory

Beauchene, C.; Hinault, T. T.; Sarma, S.; Courtney, S.

10.1101/2021.08.02.454757 — neuroscience — Posted on 2022-01-29

214 Oculomotor plant and neural dynamics suggest gaze control requires integration on distributed timescales

Miri, A.; Bhasin, B. J.; Aksay, E. R. F.; Tank, D. W.; Goldman, M. S.

10.1101/2021.06.30.450653 — neuroscience — Posted on 2022-01-29

215 Context Free and Context-Dependent Conceptual Representation in the Brain

Gao, Z.; Zheng, L.; Gouws, A.; Krieger-Redwood, K.; Wang, X.; Varga, D.; Smallwood, J.; Jefferies, E.

10.1101/2021.05.03.442424 — neuroscience — Posted on 2022-01-29

216 Decoding the temporal dynamics of affective scene processing

Bo, K.; Cui, L.; Yin, S.; Hu, Z.; Hong, X.; Kim, S.; Keil, A.; Ding, M.

10.1101/2022.01.27.478067 — neuroscience — Posted on 2022-01-29

217 The Functional Logic of Odor Information Processing in the Drosophila Antennal Lobe

Lazar, A. A.; Liu, T.; Yeh, C.-H.

10.1101/2021.12.27.474306 — neuroscience — Posted on 2022-01-29

218 Quantitative evaluation of warming and hemodilution as two techniques to increase the flow rate of blood during simulated massive transfusion of packed red blood cells

Shah, N.

10.1101/2022.01.29.478293 — physiology — Posted on 2022-01-29

219 Altered meningeal immunity contributing to the autism-like behavior of BTBR T+ Itpr3tf/J mice.

Lawrence, D. A.; Uddin, M. N.; Manley, K.

10.1101/2022.01.29.478292 — immunology — Posted on 2022-01-29

220 Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir

Stevens, L. J.; Pruijssers, A. J.; Lee, H. W.; Gordon, C. J.; Tchesnokov, E. P.; Gribble, J.; George, A. S.; Hughes, T. M.; Lu, X.; Li, J.; Perry, J. K.; Porter, D. P.; Cihlar, T.; Sheahan, T. P.; Baric, R. S.; Gotte, M.; Denison, M. R.

10.1101/2022.01.25.477724 — microbiology — Posted on 2022-01-29

221 Hyperactivation of YAP/TAZ drives alterations in mesangial cells through stabilization of N-MYC in diabetic nephropathy

Choi, S.; Suh, S. H.; Bae, H.; Kang, K. P.; Lee, H.; Koh, G. Y.

10.1101/2022.01.29.478286 — pathology — Posted on 2022-01-29

222 Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering

Purshouse, K.; Friman, E.; Boyle, S.; Dewari, P. S.; Grant, V.; Hamdan, A.; Morrison, G.; Brennan, P.; Beentjes, S.; Pollard, S.; Bickmore, W.

10.1101/2022.01.29.478046 — genetics — Posted on 2022-01-29

223 Complex and critical roles for the AtrR transcription factor in control of cyp51A expression in Aspergillus fumigatus

Paul, S.; Verweij, P. E.; Melchers, W. J. G.; Moye-Rowley, W. S.

10.1101/2022.01.28.478276 — microbiology — Posted on 2022-01-29

224 The propensity to sign-track is associated with externalizing behaviour and distinct patterns of reward-related brain activation in youth

Colaizzi, J. M.; Flagel, S. B.; Gearhardt, A. N.; Borowitz, M. A.; Kuplicki, R.; Zotev, V.; Clark, G.; Coronado, J.; Abbott, T.; Paulus, M. P.

10.1101/2022.01.29.477945 — neuroscience — Posted on 2022-01-29

225 Nonlinear super-resolution signal processing for subcellular analysis of calcium dynamics

Calcini, N.; da Silva Lantyer, A.; Zeldenrust, F.; Celikel, T.

10.1101/2022.01.29.478290 — neuroscience — Posted on 2022-01-29

226 Transcriptome Analysis of the Nematode Caenorhabditis elegans and Litoditis marina in a Chemically Defined Food Environment

Sun, P.; Cao, X.; Zhang, L.

10.1101/2022.01.28.478261 — zoology — Posted on 2022-01-29

227 Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma

Qazi, M. A.; Salim, S. K.; Brown, K. R.; Savage, N.; Mikolajewicz, N.; Han, H.; Subapanditha, M. K.; Bakhshinyan, D.; Nixon, A.; Vora, P.; Desmond, K.; Chokshi, C.; Singh, M.; Khoo, A.; Macklin, A.; Khan, S.; Tatari, N.; Winegarden, N.; Richards, L. M.; Pugh, T.; Bock, N.; Mansouri, A.; Venugopal, C.; Kislinger, T. R.; Goyal, S.; Moffat, J.; Singh, S.

10.1101/2022.01.28.478232 — cancer biology — Posted on 2022-01-29

228 Development of an Ultra Low-Cost SSVEP-based BCI Device for Real-Time On-Device Decoding

Teversham, J.; Wong, S.; Hsieh, B.; Rapeaux, A.; Troiani, F.; Savolainen, O.; Zhang, Z.; Maslik, M.; Constandinou, T.

10.1101/2022.01.29.478203 — bioengineering — Posted on 2022-01-29

229 3D Printable High Performance Conducting Polymer Hydrogel for All-Hydrogel Bioelectronics

Zhou, T.; Yuk, H.; Hu, F.; Wu, J.; Tian, F.; Roh, H.; Shen, Z.; Gu, G.; Xu, J.; Lu, B.; Zhao, X.

10.1101/2022.01.29.478311 — bioengineering — Posted on 2022-01-29

230 A guide to using GPS-based tracking to study animal societies

He, P.; Klarevas-Irby, J. A.; Papageorgiou, D.; Strauss, E. D.; Farine, D. R.

10.1101/2022.01.29.478280 — animal behavior and cognition — Posted on 2022-01-29

231 Sensory plasticity in a socially plastic bee

Boulton, R. A.; Field, J.

10.1101/2022.01.29.478030 — evolutionary biology — Posted on 2022-01-29

232 Naive Bayes Assessment of Mediterranean Basin Ecosystem Wildfires Associated With Vegetation Vigor in August 2021

Wibowo, A. A.

10.1101/2022.01.29.478296 — ecology — Posted on 2022-01-29

233 Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart

Siatra, P.; Vatsellas, G.; Chatzianastasiou, A.; Balafas, E.; Manolakou, T.; Papapetropoulos, A.; Agapaki, A.; Mouchtouri, E.-T.; Korovesi, A. G.; Mavroidis, M.; Thanos, D.; Beis, D.; Kokkinopoulos, I.

10.1101/2022.01.28.473428 — cell biology — Posted on 2022-01-29

234 Synthetic glycans that control gut microbiome structure mitigate colitis in mice

Tolonen, A. C.; Beauchemin, N.; Bayne, C.; Li, L.; Tan, J.; Lee, J.; Meehan, B.; Meisner, J.; Millet, Y.; Rapp, E.; Kottler, R.; Murphy, C.; Turnbaugh, P. J.; von Maltzahn, G.; Liu, C. M.; van Hylckama Vlieg, J.

10.1101/2022.01.28.478269 — microbiology — Posted on 2022-01-29

235 GABABR agonist baclofen promotes central nervous system remyelination

Serrano-Regal, M. P.; Bayon-Cordero, L.; Chara, J. C.; Tepavcevic, V.; Ochoa-Bueno, B. I.; Matute, C.; Sanchez-Gomez, M. V.

10.1101/2022.01.28.478233 — neuroscience — Posted on 2022-01-29

236 Categorization and discrimination of human and non-human primate affective vocalizations: investigation of the frontal cortex activity through fNIRS.

Debracque, C.; Ceravolo, L.; Clay, Z.; Grandjean, D.; Gruber, T.

10.1101/2022.01.29.478308 — neuroscience — Posted on 2022-01-29

237 Learning the Vector Coding of Egocentric Boundary Cells from Visual Data

Lian, Y.; Williams, S.; Alexander, A. S.; Hasselmo, M. E.; Burkitt, A. N.

10.1101/2022.01.28.478267 — neuroscience — Posted on 2022-01-29

238 Modelling non-local neural information processing in the brain

Balkenhol, J.; Haendel, B.; Prada, J.; Bosman, C. A.; Ehrenreich, H.; Grohmann, J.; von Kistowski, J.; Wojcik, S. M.; Kounev, S.; Blum, R.; Dandekar, T.

10.1101/2022.01.27.477993 — neuroscience — Posted on 2022-01-29

239 Circadian volume changes in hippocampal glia studied by label-free interferometric imaging

Kouzehgarani, G. N.; Kandel, M. E.; Sakakura, M.; Dupaty, J. S.; Popescu, G.; Gillette, M. U.

10.1101/2022.01.28.478218 — neuroscience — Posted on 2022-01-29

240 No priming, just fighting - endophytic yeast attenuates the defense response and the stress induced by Dutch elm disease in Ulmus minor

Sobrino-Plata, J.; Martinez-Arias, C.; Ormeno-Moncalvillo, S.; Fernandez, I.; Collada, C.; Gil, L.; Pieterse, C. M. J.; Martin, J. A.

10.1101/2022.01.29.478285 — plant biology — Posted on 2022-01-29

241 Mass-Sensitive Particle Tracking to Characterize Membrane-Associated Macromolecule Dynamics

Steiert, F.; Heermann, T.; Hundt, N.; Schwille, P.

10.1101/2022.01.27.477846 — biophysics — Posted on 2022-01-29

242 An allosteric agonist activates BK channels by perturbing coupling between Ca2+ binding and pore opening

Zhang, G.; Xu, X.; Jia, Z.; Geng, Y.; Liang, H.; Shi, J.; Marras, M.; Abella, C.; Magleby, K. L.; Silva, J. R.; Chen, J.; Zou, X.; Cui, J.

10.1101/2022.01.28.478270 — biophysics — Posted on 2022-01-29

243 Protein-Nucleic Acid Interactions for RNA Polymerase II Elongation Factors by Molecular Dynamics Simulations

Gallardo, A.; Bogart, B. M.; Dutagaci, B.

10.1101/2022.01.28.478254 — biophysics — Posted on 2022-01-29

244 maxATAC: genome-scale transcription-factor binding prediction from ATAC-seq with deep neural networks

Cazares, T. A.; Rizvi, F. W.; Iyer, B.; Chen, X.; Kotliar, M.; Wayman, J. A.; Bejjani, A.; Donmez, O.; Wronowski, B.; Parameswaran, S.; Kottyan, L. C.; Barski, A.; Weirauch, M. T.; Prasath, V. S.; Miraldi, E. R.

10.1101/2022.01.28.478235 — bioinformatics — Posted on 2022-01-29

245 Modular and programmable RNA sensing using ADAR editing in living cells

Kaseniit, K. E.; Katz, N.; Kolber, N. S.; Call, C. C.; Wengier, D. L.; Cody, W. B.; Sattely, E. S.; Gao, X. J.

10.1101/2022.01.28.478207 — bioengineering — Posted on 2022-01-29

246 Feedback in the β-catenin destruction complex imparts bistability and cellular memory

Cantoria, M. J.; Alizadeh, E.; Ravi, J.; Bunnag, N.; Kettenbach, A. N.; Ahmed, Y.; Paek, A. L.; Tyson, J. J.; Doubrovinski, K.; Lee, E.; Thorne, C. A.

10.1101/2022.01.28.478206 — cell biology — Posted on 2022-01-29

247 Molecular hydrogen is an overlooked energy source for marine bacteria

Lappan, R.; Shelley, G.; Islam, Z. F.; Leung, P. M.; Lockwood, S.; Nauer, P. A.; Jirapanjawat, T.; Chen, Y.-J.; Kessler, A. J.; Williams, T. J.; Cavicchioli, R.; Baltar, F.; Cook, P. L. M.; Morales, S. E.; Greening, C.

10.1101/2022.01.29.478295 — microbiology — Posted on 2022-01-29

248 Sparse spike trains and the limitations of rate codes underlying rapid behaviour

Fabian, J. M.; O'Carroll, D. C.; Wiederman, S. D.

10.1101/2022.01.28.478240 — neuroscience — Posted on 2022-01-29

249 The genome sequence of Hirschfeldia incana, a species with high photosynthetic light-use efficiency

Garassino, F.; Wijfjes, R. Y.; Boesten, R.; Becker, F. F. M.; Clapero, V.; van den Hatert, I.; Holmer, R.; Schranz, M. E.; Harbinson, J.; de Ridder, D.; Smit, S.; Aarts, M. G. M.

10.1101/2022.01.29.478283 — bioinformatics — Posted on 2022-01-29

250 Interaction with TopBP1 mediates human papillomavirus 16 E2 plasmid segregation/retention function and stability during the viral life cycle

Prabhakar, A. T.; James, C. D.; Das, D.; Fontan, C.; Otoa, R.; Wang, X.; Bristol, M. L.; Morgan, I. M.

10.1101/2022.01.28.478274 — molecular biology — Posted on 2022-01-29

251 Evolution of β-lactamase mediated cefiderocol resistance

Frohlich, C.; Sorum, V.; Tokuriki, N.; Johnsen, P. J.; Samuelsen, O.

10.1101/2022.01.29.478156 — molecular biology — Posted on 2022-01-29

252 Antibodies to native gluten arise from cross-reactive B cells with implications for epitope spreading in celiac disease

Zhou, C.; Osterbye, T.; Dahal-Koirala, S.; Steinsbo, O.; Jahnsen, J.; Lundin, K. E. A.; Buus, S.; Sollid, L. M.; Iversen, R.

10.1101/2022.01.29.478298 — immunology — Posted on 2022-01-29

253 iCn3D: From Web-based 3D Viewer to Structure Analysis Tool in Batch Mode

Wang, J.; Youkharibache, P.; Marchler-Bauer, A.; Lanczycki, C.; Zhang, D.; Lu, S.; Madej, T.; Marchler, G. H.; Cheng, T.; Chong, L. C.; Zhao, S.; Yang, K.; Lin, J.; Cheng, Z.; Dunn, R.; Malkaram, S. A.; Tai, C.-H.; Enoma, D.; Busby, B.; Johnson, N.; Tabaro, F.; Song, G.; Ge, Y.

10.1101/2021.09.10.459868 — bioinformatics — Posted on 2022-01-29

254 An End-to-End Deep Learning Speech Coding and Denoising Strategy for Cochlear Implants

Gajecki, T.; Nogueira, W.

10.1101/2021.11.04.467324 — bioengineering — Posted on 2022-01-29

255 Reduction in cardiolipin reduces expression of creatine transporter-1 and creatine transport in hBMEC/D3 human brain microvessel endothelial cells

Miller, D. W.; Hatch, G. M.

10.1101/2022.01.29.478231 — biochemistry — Posted on 2022-01-29

256 Spatial and molecular anatomy of germ layers in the gastrulating primate embryo

Cui, G.; Feng, S.; Yan, Y.; Wang, L.; He, X.; Li, X.; Duan, Y.; Chen, J.; Tam, P. P. L.; Tang, K.; Zheng, P.; Si, W.; Jing, N.; Peng, G.

10.1101/2022.01.26.474719 — developmental biology — Posted on 2022-01-29

257 Direct DNA sequencing of "Candidatus Liberibacter asiaticus" from Diaphorina citri, the Asian citrus psyllid, and its implications for citrus greening disease management

Higgins, S. A.; Mann, M.; Heck, M. L.

10.1101/2022.01.28.478250 — microbiology — Posted on 2022-01-29

258 Autotaxin is a Potential Link between Genetic Risk Factors and Pathogenesis of Systematic Lupus Erythematosus in Plasmacytoid Dendritic Cells

Tsuchida, Y.; Shoda, H.; Nakano, M.; Ota, M.; Okamura, T.; Yamamoto, K.; Kurano, M.; Yatomi, Y.; Fujio, K.; Sawada, T.

10.1101/2021.10.25.465592 — immunology — Posted on 2022-01-29

259 Myelin Imaging Using 3D Dual-echo Ultra-short Echo Time MRI with Rosette k-Space Pattern

Shen, X.; Ozen, A.; Susnjar, A.; Ilbey, S.; Shi, R.; Chiew, M.; emir, u.

10.1101/2021.09.18.460869 — neuroscience — Posted on 2022-01-29

260 Correction of the scientific production: publisher performance evaluation using a dataset of 4844 PubMed retractions.

Toma, C. S.; Padureanu, L.; Toma, B.

10.1101/2022.01.23.477400 — scientific communication and education — Posted on 2022-01-29

261 P2X2 receptor subunit interfaces are missense variant hotspots where mutations tend to increase apparent ATP affinity

Gasparri, F.; Sarkar, D.; Bielickaite, S.; Poulsen, M. H.; Hauser, A.; Pless, S. A.

10.1101/2021.03.26.436616 — biophysics — Posted on 2022-01-29

262 Identifying Microbial Interaction Networks Based on Irregularly Spaced Longitudinal 16S rRNA sequence data

Zhou, J.; Gui, J.; Viles, W. D.; Hoen, A. G.

10.1101/2021.11.26.470159 — bioinformatics — Posted on 2022-01-29

263 PPRD: a comprehensive online database for expression analysis of ~45,000 plant public RNA-Seq libraries

Yu, Y.; Zhang, H.; Long, Y.; Shu, Y.; Zhai, J.

10.1101/2022.01.28.477949 — plant biology — Posted on 2022-01-29

264 Mucins form a nanoscale material barrier against immune cell attack

Park, S.; Colville, M. J.; Shurer, C. R.; Huang, L.-T.; Kuo, J. C.-H.; Paek, J. H.; Goudge, M. C.; Su, J.; DeLisa, M. P.; Lammerding, J.; Zipfel, W. R.; Fischbach, C.; Reesink, H. L.; Paszek, M. J.

10.1101/2022.01.28.478211 — biophysics — Posted on 2022-01-29

265 Deep learning of Protein Sequence Design of Protein-protein Interactions

Syrlybaeva, R.; Strauch, E.-M.

10.1101/2022.01.28.478262 — bioinformatics — Posted on 2022-01-29

266 A novel genomic DNA library preparation method with low GC bias

Kelly, T.; Haokoyama, T.; Kumaishi, K.; Yabukami, H.; Kato, S.; Hayashi, M.; Minoda, A.; Ichihashi, Y.

10.1101/2022.01.28.478268 — genomics — Posted on 2022-01-29

267 A nucleation barrier spring-loads the CBM signalosome for binary activation

Rodriguez Gama, A.; Miller, T.; Lange, J. J.; Unruh, J.; Halfmann, R.

10.1101/2022.01.28.477912 — cell biology — Posted on 2022-01-29

268 Inner membrane complex proteomics reveals a palmitoylation cascade regulating intraerythrocytic development of malaria parasite

Qian, P.; Wang, X.; Zhong, C.-Q.; Wang, J.; Li, J.; Cui, H.; Yuan, J.

10.1101/2022.01.28.478263 — microbiology — Posted on 2022-01-29

269 Lactate Signaling Mediated by AMD3100 Ameliorates Astrocyte Pathology and Remyelination Without Additional Extension of SOD1G93A Mice' Life-Span

Rabinovich-Nikitin, I.; Solomon, B.

10.1101/2022.01.28.478264 — neuroscience — Posted on 2022-01-29

270 Decline in Environmental Quality and Spatial Dynamics of New City Area Development Metropolitan Mamminasata, South Sulawesi, Indonesia

Surya, B.; Salim, A.; Sariman, S.; Hernita, H.; Saleh, H.; Suriani, S.; Nasrullah, N.; Rasyidi, E. S.; Syahrul Sariman,

10.1101/2022.01.28.478145 — ecology — Posted on 2022-01-28

271 Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks?

Milde, A. M.; Kinn, A. M. R.; Brekke, S.; Gjoen, H.; Mesfin, G.; Murison, R.

10.1101/2022.01.28.478146 — physiology — Posted on 2022-01-28

272 An optimized method for the isolation of urinary extracellular vesicles for molecular phenotyping: detection of biomarkers for radiation exposure

Hinzman, C. P.; Jayatilake, M.; Bansal, S.; Fish, B. L.; Li, Y.; Zhang, Y.; Bansal, S.; Girgis, M.; Iliuk, A.; Xu, X.; Fernandez, J. A.; Griffin, J. H.; Ballew, E. A.; Unger, K.; Boerma, M.; Medhora, M.; Cheema, A. K.

10.1101/2022.01.28.477909 — cancer biology — Posted on 2022-01-28

273 Development and characterization of a human arteriovenous malformation (AVM)-on-a-chip model

Soon, K.; Li, M.; Wu, R.; Turner, W. D.; Wythe, J. D.; Fish, J. E.; Nunes, S. S.

10.1101/2022.01.20.477166 — bioengineering — Posted on 2022-01-28

274 Identification of 121 variants of honey bee Vitellogenin protein sequences with structural differences at functional sites

Leipart, V.; Ludvigsen, J.; Kent, M.; Sandve, S.; To, T.-H.; Arnyasi, M.; Kreibich, C. D.; Dahle, B.; Amdam, G. V.

10.1101/2022.01.28.478245 — biochemistry — Posted on 2022-01-28

275 Single-cell mutation calling and phylogenetic tree reconstruction with loss and recurrence

Kuipers, J.; Singer, J.; Beerenwinkel, N.

10.1101/2022.01.28.478229 — genomics — Posted on 2022-01-28

276 Genome size evolution in the beetle genus Diabrotica

Lata, D.; Coates, B. S.; Walden, K. K. O.; Robertson, H. M.; Miller, N. J.

10.1101/2021.09.04.458993 — genomics — Posted on 2022-01-28

277 Emergent evolutionary forces in spatial models of microbial growth in the human gut microbiota

Ghosh, O. M.; Good, B. H.

10.1101/2021.07.15.452569 — evolutionary biology — Posted on 2022-01-28

278 Convergent extension requires adhesion-dependent biomechanical integration of cell crawling and junction contraction

Weng, S.; Huebner, R.; Wallingford, J. B.

10.1101/2021.01.12.426405 — developmental biology — Posted on 2022-01-28

279 A study of thermally-induced sex reversal in casque-headed lizards

Suarez, G.; Mendoza-Cruz, E.; Acosta, A.; Villagran-Santa Cruz, M.; Cortez, D.; Hernandez-Gallegos, O.

10.1101/2022.01.28.478147 — developmental biology — Posted on 2022-01-28

280 Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies

Robinson, C.-A.; Singh, G. K.; Kleer, M.; Castle, E. L.; Boudreau, B. Q.; Corcoran, J.

10.1101/2021.02.07.430164 — cell biology — Posted on 2022-01-28

281 Lysophosphatidylcholine acyltransferase 2 (LPCAT2) Regulates The Expression of Macrophage Phenotype Markers in RAW264.7 Cells.

Poloamina, V. I.; Alrammah, H.; Abate, W.; Avent, N.; Fejer, G.; Jackson, S. K.

10.1101/2021.11.25.469956 — immunology — Posted on 2022-01-28

282 Sex differences in behavioral responding and dopamine release during Pavlovian learning

Lefner, M. J.; Dejeux, M. I.; Wanat, M. J.

10.1101/2021.10.04.463059 — neuroscience — Posted on 2022-01-28

283 Radiosynthesis and preclinical evaluation of a carbon-11 labeled PDE7 inhibitor for PET neuroimaging

Xiao, Z.; Sun, J.; Fujinaga, M.; Wei, H.; Zhao, C.; Haider, A.; Van, R.; Yamasaki, T.; Zhang, Y.; Rong, J.; Hu, K.; Chen, J.; Leon, E. C.; Hiraishi, A.; Wei, J.; Xu, Y.; Shao, Y.; Zhang, H.-T.; Xu, Y.; Lloyd, K. C. K.; Wang, L.; Zhang, M.-R.; Liang, S. H.

10.1101/2021.06.12.447900 — neuroscience — Posted on 2022-01-28

284 Environmental enrichment mitigatesthe long-lasting sequelae of perinatal fentanyl exposure

Alipio, J. B.; Riggs, L. M.; Plank, M.; Keller, A.

10.1101/2021.07.31.454575 — neuroscience — Posted on 2022-01-28

285 High expression of VRT2 increases the number of rudimentary basal spikelets in wheat

Backhaus, A. E.; Lister, A.; Tomkins, M.; Adamski, N. M.; Simmonds, J.; Macaulay, I. C.; Morris, R. J.; Haerty, W.; Uauy, C.

10.1101/2021.08.03.454952 — plant biology — Posted on 2022-01-28

286 Using the UniFrac metric on Whole Genome Shotgun data

Wei, W.; Koslicki, D.

10.1101/2022.01.17.476629 — bioinformatics — Posted on 2022-01-28

287 A role for heritable transcriptomic variation in maize adaptation to temperate environments

Sun, G.; Yu, H.; Wang, P.; Guerrero, M. G. L.; Mural, R. V.; Mizero, O. N.; Grzybowski, M.; Song, B.; van Dijk, K.; Schachtman, D. P.; Zhang, C.; Schnable, J. C.

10.1101/2022.01.28.478212 — bioinformatics — Posted on 2022-01-28

288 Strong immobilization of C. elegans en masse on cultivation plates by thermoelectric cooling for high-throughput submicron-resolution microscopy

Wang, Y. L.; Jaklitsch, E. L.; Grooms, N. W. F.; Schulting, L. G.; Chung, S. H.

10.1101/2021.12.09.471981 — bioengineering — Posted on 2022-01-28

289 Bioinspired Stretchable Transducer for Wearable Continuous Monitoring of Respiratory Patterns in Humans and Animals

Cotur, Y.; Olenik, S.; Asfour, T.; Bruyns-Haylett, M.; Kasimatis, M.; Tanriverdi, U.; Gonzalez-Macia, L.; Lee, H. S.; Kozlov, A. S.; Guder, F.

10.1101/2022.01.24.477637 — bioengineering — Posted on 2022-01-28

290 Endogenous pancreatic microRNAs differentially target the Delta, Omicron, and Wuhan SARS-CoV-2 genomes to upregulate the Diabetes-associated genes

Bhavya, B.; Pathak, E.; Mishra, R.

10.1101/2022.01.26.477612 — genomics — Posted on 2022-01-28

291 Recurring adaptive introgression of a supergene variant that determines social organization

Stolle, E.; Pracana, R.; Lopez-Osorio, F.; Priebe, M. K.; Hernandez, G. L.; Castillo-Carrillo, C.; Arias, M. C.; Paris, C. I.; Bollazzi, M.; Priyam, A.; Wurm, Y.

10.1101/2021.04.11.439370 — evolutionary biology — Posted on 2022-01-28

292 Dynamic changes to signal allocation rules in response to variable social environments in house mice

Miller, C. H.; Hillock, M. F.; Yang, J.; Carlson-Clarke, B.; Haxhillari, K.; Lee, A. Y.; Warden, M. R.; Sheehan, M. J.

10.1101/2022.01.28.478242 — ecology — Posted on 2022-01-28

293 From microbes to mammals: pond biodiversity homogenization across different land-use types in an agricultural landscape

Ionescu, D.; Bizic, M.; Karnatak, R.; Musseay, C. L.; Onandia, G.; Kasada, M.; Berger, S. A.; Nejstgaard, J. C.; Ryo, M.; Lischeid, G.; Gessner, M. O.; Wollrab, S.; Grossart, H.-P.

10.1101/2022.01.28.477988 — ecology — Posted on 2022-01-28

294 Maintenance of community function through compensation breaks down over time in a desert rodent community

Diaz, R. M.; Ernest, S. K. M.

10.1101/2021.10.01.462799 — ecology — Posted on 2022-01-28

295 Single-cell Transcriptome and Accessible Chromatin Dynamics During Endocrine Pancreas Development

Duvall, E.; Benitez, C. M.; Tellez, K.; Enge, M.; Pauerstein, P. T.; Li, L.; Baek, S.; Quake, S. R.; Smith, J. P.; Sheffield, N. C.; Kim, S. K.; Arda, H. E.

10.1101/2022.01.28.478217 — developmental biology — Posted on 2022-01-28

296 CRY-BARs: Versatile light-gated molecular tools for the remodeling of membrane architectures

Wurz, A. I.; Bunner, W. P.; Szatmari, E. M.; Hughes, R. M.

10.1101/2022.01.28.478241 — cell biology — Posted on 2022-01-28

297 cir-DNA sequencing revealed the landscape of extrachromosomal circular DNA in articular cartilage and the potential roles in osteoarthritis

Xiang, W.; Zhang, T.; Li, S.; Gong, Y.; Luo, X.; Yuan, J.; Wu, Y.; Yan, X.; Xiong, Y.; Liang, J.; Zhao, G.; Gao, C.; Kuang, L.; Ni, Z.

10.1101/2022.01.27.477985 — molecular biology — Posted on 2022-01-28

298 De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals

Tetreau, G.; Sawaya, M. R.; De Zitter, E.; Andreeva, E. A.; Banneville, A.-S.; Schibrowsky, N.; Coquelle, N.; Brewster, A. S.; Grunbein, M. L.; Nass-Kovacs, G.; Hunter, M. S.; Kloos, M.; Sierra, R. G.; Schiro, G.; Qiao, P.; Stricker, M.; Bideshi, D.; Young, I. D.; Zala, N.; Engilberge, S.; Gorel, A.; Signor, L.; Teulon, J.-M.; Hilpert, M.; Foucar, L.; Bielecki, J.; de Wijn, R.; Sato, T.; Kirkwood, H.; Bean, R.; Letrun, R.; Batyuk, A.; Snigireva, I.; Fenel, D.; Schubert, R.; Canfield, E. J.; Alba, M. M.; Laporte, F.; Despres, L.; Bacia, M.; Roux, A.; Chapelle, C.; Riobe, F.; Maury, O.; Ling, W.

10.1101/2021.12.15.472578 — molecular biology — Posted on 2022-01-28

299 Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

Koh, E.-I.; Oluoch, P. O.; Ruecker, N.; Proulx, M. K.; Soni, V.; Murphy, K. C.; Papavinasasundaram, K. G.; Reames, C. J.; Trujillo, C.; Zaveri, A.; Zimmerman, M. D.; Aslebagh, R.; Baker, R. E.; Shaffer, S. A.; Guinn, K. M.; Fitzgerald, M.; Dartois, V. A.; Ehrt, S.; Hung, D. T.; Ioerger, T. R.; Rubin, E.; Rhee, K. Y.; Schnappinger, D.; Sassetti, C. M.

10.1101/2021.04.08.439092 — microbiology — Posted on 2022-01-28

300 DNA damage independent inhibition of NF-κB transcription by anthracyclines

Chora, A.; Pedroso, D.; Pejanovic, N.; Kyriakou, E.; Colaco, H.; Gozzelino, R.; Barros, A.; Willmann, K.; Velho, T.; Moita, C.; Santos, I.; Carvalho, S.; Martins, F.; Ferreira, J.; Almeida, S.; Benes, V.; Anrather, J.; Soares, M.; Geerlof, A.; Neefjes, J.; Sattler, M.; Messias, A.; Neves-Costa, A.; Moita, L. F.

10.1101/2020.04.27.065003 — immunology — Posted on 2022-01-28

Koen, J. D.

10.1101/2021.08.27.457968 — neuroscience — Posted on 2022-01-28

302 A partially nested cortical hierarchy of neural states underlies event segmentation in the human brain

Geerligs, L.; Gözükara, D.; Oetringer, D.; Campbell, K.; van Gerven, M.; Güclü, U.

10.1101/2021.02.05.429165 — neuroscience — Posted on 2022-01-28

303 Understanding associative false memories in aging using multivariate analyses

Dennis, N. A.; Overman, A. A.; Carpenter, C. M.; Gerver, C. R.

10.1101/2021.07.26.453271 — neuroscience — Posted on 2022-01-28

304 Ipsilateral stimulus encoding in primary and secondary somatosensory cortex of awake mice

Pala, A.; Stanley, G. B.

10.1101/2021.07.16.452704 — neuroscience — Posted on 2022-01-28

305 Molecular markers of mechanosensation in glycinergic neurons in the avian lumbosacral spinal cord

Stanchak, K. E.; Miller, K. E.; Lumsden, E. W.; Shikiar, D.; Davis, C.; Brunton, B. W.; Perkel, D. J.

10.1101/2022.01.28.478253 — neuroscience — Posted on 2022-01-28

306 Multiple Synaptic Contacts combined with Dendritic Filtering enhance Spatio-Temporal Pattern Recognition capabilities of Single Neurons

Beniaguev, D.; Shapira, S.; Segev, I.; London, M.

10.1101/2022.01.28.478132 — neuroscience — Posted on 2022-01-28

307 Human cortical areas are sparsely connected: Combining histology with diffusion MRI to estimate the absolute number of axons

Rosen, B. Q.; Halgren, E.

10.1101/2021.06.07.447453 — neuroscience — Posted on 2022-01-28

308 Priority-based transformations of stimulus representation in visual working memory

Wan, Q.; Menendez, J. A.; Postle, B. R.

10.1101/2021.05.13.443973 — neuroscience — Posted on 2022-01-28

309 Within and among population differences in cuticular hydrocarbons in the seabird tick Ixodes uriae.

Dupraz, M.; Leroy, C.; Thorarinsson, T. L.; dEttorre, P.; McCoy, K.

10.1101/2022.01.21.477272 — zoology — Posted on 2022-01-28

310 BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity

Hickman, T. L.; Choi, E.; Whiteman, K. R.; Muralidharan, S.; Pai, T.; Johnson, T.; Parikh, A.; Friedman, T.; Gilbert, M.; Shen, B.; Barron, L.; McGinness, K. E.; Ettenberg, S. A.; Motz, G. T.; Weiss, G. J.; Jensen-Smith, A.

10.1101/2021.11.17.469041 — cancer biology — Posted on 2022-01-28

311 Water-Only Look-Locker Inversion recovery (WOLLI) T1 mapping

Garrison, L. D.; Levick, C.; Pavlides, M.; Marjot, T.; Mozes, F.; Hodson, L.; Neubauer, S.; Robson, M.; Rodgers, C. T.

10.1101/2022.01.28.478209 — biophysics — Posted on 2022-01-28

312 Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

Abskharon, R.; Sawaya, M. R.; Boyer, D. R.; Cao, Q.; Nguyen, B. A.; Cascio, D.; Eisenberg, D. S.

10.1101/2022.01.28.478258 — biophysics — Posted on 2022-01-28

313 QT-GILD: Quartet Based Gene Tree Imputation Using Deep Learning Improves Phylogenomic Analyses Despite Missing Data

Mahbub, S.; Sawmya, S.; Saha, A.; Reaz, R.; Rahman, M. S.; Bayzid, M. S.

10.1101/2021.11.03.467204 — bioinformatics — Posted on 2022-01-28

314 Extending Bayesian Elo-rating to quantify dominance hierarchy steepness

Neumann, C.; Fischer, J.

10.1101/2022.01.28.478016 — animal behavior and cognition — Posted on 2022-01-28

315 Nematodes can survive in a suspended form of life for indefinite time

Shatilovich, A.; Gade, V. R.; Pippel, M.; Hoffmeyer, T. T.; Tchesunov, A. V.; Stevens, L.; Winkler, S.; Hughes, G. M.; Traikov, S.; Hiller, M.; Rivkina, E.; Schiffer, P. H.; Myers, E. W.; Kurzchalia, T. V.

10.1101/2022.01.28.478251 — genomics — Posted on 2022-01-28

316 Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL data

Ehsan, N.; Kotis, B.; Castel, S.; Song, E.; Mancuso, N.; Mohammadi, P.

10.1101/2022.01.28.478116 — genetics — Posted on 2022-01-28

317 AICAR-mediated selection of karyotypically normal cells in Pallister-Killian syndrome patient-derived skin fibroblasts

Salzano, E.; Kaur, M.; Jacko, A. M.; Mceldrew, D. A.; Raible, S. E.; Krantz, I. D.; Izumi, K.

10.1101/2022.01.27.478025 — cell biology — Posted on 2022-01-28

318 Strong interactions between highly-dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin

Tolokh, I. S.; Kinney, N. A.; Sharakhov, I. V.; Onufriev, A. V.

10.1101/2022.01.28.478236 — molecular biology — Posted on 2022-01-28

319 A single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

Drebes Doerr, N. C.; Proutiere, A.; Jaskolska, M.; Stutzmann, S.; Bader, L.; Blokesch, M.

10.1101/2022.01.28.478222 — microbiology — Posted on 2022-01-28

320 Tardigrade community microbiomes in North American orchards include putative endosymbionts and plant pathogens

Tibbs-Cortes, L. E.; Tibbs-Cortes, B. W.; Schmitz-Esser, S.

10.1101/2022.01.28.478239 — microbiology — Posted on 2022-01-28

321 Campylobacter jejuni induces differentiation of human neutrophils to the CD16hi/CD62Llo subtype which possess cancer promoting activities

Dolislager, C. G.; Callahan, S. M.; Donohoe, D. R.; Johnson, J. G.

10.1101/2022.01.28.478176 — microbiology — Posted on 2022-01-28

322 Sex-specific regulation of binge drinking and affective behaviors by subcortical serotonin 5HT2c receptors

Flanigan, M. E.; Hon, O. J.; D'Ambrosio, S.; Boyt, K. M.; Hassanein, L.; Castle, M. E.; Haun, H. L.; Pina, M. M.; Kash, T. L.

10.1101/2022.01.28.478036 — neuroscience — Posted on 2022-01-28

323 Cerebro-cerebellar networks facilitate learning through feedback decoupling

Boven, E.; Pemberton, J.; Chadderton, P.; Apps, R.; Costa, R. P.

10.1101/2022.01.28.477827 — neuroscience — Posted on 2022-01-28

324 On the clinical benefit of on-scalp MEG: A modeling study of on-scalp MEG epileptic activity source estimation ability

Westin, K.; Beniczky, S.; Hamalainen, M.; Lundqvist, D.

10.1101/2022.01.28.478237 — neuroscience — Posted on 2022-01-28

325 Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning

Martin, K. A.; Papadoyannis, E. S.; Schiavo, J. K.; Shokat Fadaei, S.; Temiz, N. Z.; McGinley, M. J.; McCormick, D. A.; Froemke, R. C.

10.1101/2022.01.28.478197 — neuroscience — Posted on 2022-01-28

326 Curiosity and mesolimbic functional connectivity drive information seeking in real life

Eschmann, K. C. J.; Pereira, D. F. M. M.; Valji, A.; Dehmelt, V.; Gruber, M. J.

10.1101/2022.01.28.478038 — neuroscience — Posted on 2022-01-28

327 Face processing in the infant brain after pandemic lockdown

Yates, T. S.; Ellis, C. T.; Turk-Browne, N. B.

10.1101/2022.01.26.477758 — neuroscience — Posted on 2022-01-28

328 Mechanodetection of neighbor plants elicits adaptive leaf movements through calcium dynamics

Pantazopoulou, C. K.; Buti, S.; Nguyen, C. T.; Oskam, L.; Farmer, E.; Kajala, K.; Pierik, R.

10.1101/2022.01.28.478192 — plant biology — Posted on 2022-01-28

329 Neurogenesis and angiogenesis are associated features of aggressive breast cancer

Wik, E.; Aziz, S.; Vethe, H.; Askeland, C.; Finne, K.; Knutsvik, G.; Winge, I.; Kruger, K.; Mannelqvist, M.; Svanoe, A. A.; Birkeland, E.; Kjolle, S.; Davidsen, B.; Aas, T.; Stefansson, I. M.; Kleftogiannis, D.; Akslen, L. A.

10.1101/2022.01.28.477898 — cancer biology — Posted on 2022-01-28

330 Comparative analysis of machine learning algorithms on the microbial strain-specific AMP prediction

Vishnepolsky, B.; Grigolava, M.; Managadze, G.; Gabrielian, A.; Rosenthal, A.; Hurt, D. E.; Tartakovsky, M.; Pirtskhalava, M.

10.1101/2022.01.28.478081 — bioinformatics — Posted on 2022-01-28

331 The adapted Activity-By-Contact-model for enhancer-gene assignment and its combination with transcription factor affinities in single cell data

Hecker, D.; Behjati Ardakani, F.; Schulz, M. H.

10.1101/2022.01.28.478202 — bioinformatics — Posted on 2022-01-28

332 A methodology for co-simulation-based optimization of biofabrication protocols

Giannantoni, L.; Bardini, R.; Di Carlo, S.

10.1101/2022.01.28.478198 — bioinformatics — Posted on 2022-01-28

333 In vivo correction of cystic fibrosis mediated by PNA nanoparticles

Piotrowski-Daspit, A. S.; Barone, C.; Lin, C.-Y.; Deng, Y.; Wu, D.; Binns, T. C.; Xu, E.; Ricciardi, A. S.; Putman, R.; Nguyen, R.; Gupta, A.; Fan, R.; Glazer, P.; Saltzman, W. M.; Egan, M. E.

10.1101/2022.01.28.478191 — bioengineering — Posted on 2022-01-28

334 Evaluation of P. aeruginosa attachment on mineralized collagen scaffolds and addition of manuka honey to increase mesenchymal stem cell osteogenesis

Dewey, M. J.; Collins, A. J.; Tiffany, A.; Barnhouse, V. R.; Lu, C.; Kolliopoulos, V.; Hickok, N. J.; Harley, B. A.

10.1101/2022.01.28.478244 — bioengineering — Posted on 2022-01-28

335 Where Honey Bee Vitellogenin may Bind Zn2+-Ions

Leipart, V.; Enger, O.; Turcu, D. C.; Dobrovolska, O.; Drablos, F.; Halskau, O.; Amdam, G. V.

10.1101/2022.01.28.478200 — biochemistry — Posted on 2022-01-28

336 A Chemical Mutagenesis Approach to Insert Post-Translational Modifications in Aggregation-Prone Proteins

Ge, Y.; Masoura, A.; Yang, J.; Aprile, F. A.

10.1101/2022.01.28.478135 — biochemistry — Posted on 2022-01-28

337 Multimodal single cell sequencing of human diabetic kidney disease implicates chromatin accessibility and genetic background in disease progression

Wilson, P. C.; Muto, Y.; Wu, H.; Karihaloo, A.; Waikar, S. S.; Humphreys, B.

10.1101/2022.01.28.478204 — genomics — Posted on 2022-01-28

338 Inserting Cre Recombinase into the Prolactin 8a2 gene for Decidua-Specific recombination in Mice

Dickson, M. J.; Oh, Y. S.; Gruzdev, A.; Li, R.; Balaguer, N.; Kelleher, A. M.; Spencer, T. E.; Wu, S.-P.; DeMayo, F. J.

10.1101/2022.01.28.478238 — genetics — Posted on 2022-01-28

339 Hsp78-interaction proteome highlights chaperone role during protein aggregation in mitochondria under heat stress

Jaworek, W.; Sylvester, M.; Cenini, G.; Voos, W.

10.1101/2022.01.28.478199 — cell biology — Posted on 2022-01-28

340 Lymphatics constitute a novel component of the intestinal stem cell niche

Goto, N.; Imada, S.; Deshpande, V.; Yilmaz, O. H.

10.1101/2022.01.28.478205 — cell biology — Posted on 2022-01-28

341 Ablation of colonic epithelial Reg4+ support cells induces Notch-independent regeneration and mesenchymal remodeling.

Wheeler, T.; Zemper, A. E.

10.1101/2022.01.28.478243 — cell biology — Posted on 2022-01-28

342 Mapping SARS-CoV-2 antigenic relationships and serological responses

Wilks, S. H.; Muhlemann, B.; Shen, X.; Tureli, S.; LeGresley, E. B.; Netzl, A.; Caniza, M. A.; Chacaltana-Huarcaya, J. N.; Daniell, X.; Datto, M. B.; Denny, T. N.; Drosten, C.; Fouchier, R. A. M.; Garcia, P. J.; Halfmann, P. J.; Jassem, A.; Jones, T. C.; Kawaoka, Y.; Krammer, F.; McDanal, C.; Pajon, R.; Simon, V.; Stockwell, M.; Tang, H.; van Bakel, H.; Webby, R.; Montefiori, D. C.; Smith, D. J.

10.1101/2022.01.28.477987 — immunology — Posted on 2022-01-28

343 Neuroprotective effects of Canagliflozin: lessons from aged genetically diverse UM-HET3 mice.

Jayarathne, H. S. M.; Debarba, L. K.; Jaboro, J. J.; Miller, R. A.; Sadagurski, M.

10.1101/2022.01.27.478017 — neuroscience — Posted on 2022-01-28

344 mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder.

Gurgone, A.; Pizzo, R.; Raspanti, A.; Chiantia, G.; Devi, S.; Morello, N.; Pilotto, F.; Gnavi, S.; Lupori, L.; Mazziotti, R.; Sagona, G.; Putignano, E.; Nocentini, A.; Supuran, C. T.; Marcantoni, A.; Pizzorusso, T.; Giustetto, M.

10.1101/2022.01.28.478021 — neuroscience — Posted on 2022-01-28

345 Extrinsic mortality and senescence: a guide for the perplexed

de Vries, C. d.; Galipaud, M.; Kokko, H.

10.1101/2022.01.27.478060 — evolutionary biology — Posted on 2022-01-28

346 Probabilistic forward replay of anticipated stimulus sequences in human primary visual cortex and hippocampus

Ekman, M.; Gennari, G.; de Lange, F.

10.1101/2022.01.26.477907 — neuroscience — Posted on 2022-01-28

347 Connectivity dynamics and cognitive variability during aging

Jauny, G.; Eustache, F.; Hinault, T. T.

10.1101/2022.01.26.477817 — neuroscience — Posted on 2022-01-28

348 High spatial overlap but diverging age-related trajectories of cortical MRI markers aiming to represent intracortical myelin and microstructure

Parent, O.; Olafson, E.; Bussy, A.; Tullo, S.; Blostein, N.; Salaciak, A.; Bedford, S. A.; Farzin, S.; Beland, M.-L.; Valiquette, V.; Tardif, C. L.; Devenyi, G. A.; Chakravarty, M. M.

10.1101/2022.01.27.477925 — neuroscience — Posted on 2022-01-28

349 Cross-modality supervised image restoration enables nanoscale tracking of synaptic plasticity in living mice

Xu, Y. K. T.; Graves, A. R.; Coste, G. I.; Huganir, R. L.; Bergles, D. E.; Charles, A. S.; Sulam, J.

10.1101/2022.01.27.478042 — neuroscience — Posted on 2022-01-28

350 Structural covariance and heritability of the optic tract and primary visual cortex in living human brains

Miyata, T.; Benson, N. C.; Winawer, J.; Takemura, H.

10.1101/2022.01.27.477973 — neuroscience — Posted on 2022-01-28

351 Penalized Decomposition Using Residuals (PeDecURe) for Nuisance Variable Adjustment in Multivariate Pattern Analysis

Weinstein, S. M.; Davatzikos, C.; Doshi, J.; Linn, K. A.; Shinohara, R. T.; the Alzheimer's Disease Neuroimaging Initiative,

10.1101/2022.01.27.477859 — neuroscience — Posted on 2022-01-28

352 An endogenous Rtn4/Nogo-interacting micropeptide that modulates synaptic plasticity with age.

Kragness, S.; Clark, Z.; Mullin, A.; Guidry, J.; Earls, L. R.

10.1101/2022.01.26.477857 — neuroscience — Posted on 2022-01-28

353 Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

Ximerakis, M.; Holton, K. M.; Giadone, R. M.; Ozek, C.; Saxena, M.; Santiago, S.; Adiconis, X.; Dionne, D.; Nguyen, L.; Shah, K. M.; Goldstein, J. M.; Gasperini, C.; Lipnick, S. L.; Simmons, S. K.; Buchanan, S. M.; Wagers, A. J.; Regev, A.; Levin, J. Z.; Rubin, L. L.

10.1101/2022.01.27.477911 — neuroscience — Posted on 2022-01-28

354 Static magnetic stimulation induces structural plasticity at the axon initial segment of inhibitory cortical neurons

Beros, J. L.; King, E. S.; Clarke, D.; Rodger, J.; Tang, A.

10.1101/2022.01.26.477963 — neuroscience — Posted on 2022-01-28

355 Cueing motor memory reactivation during NREM sleep engenders learning-related changes in precuneus and sensorimotor structures

Rakowska, M.; Bagrowska, P.; Lazari, A.; Navarrete, M.; Abdellahi, M. E. A.; Johansen-Berg, H.; Lewis, P. A.

10.1101/2022.01.27.477838 — neuroscience — Posted on 2022-01-28

356 Resveratrol increases tear production and spontaneous ocular pain after corneal abrasion in male, but not female, rats using a preclinical model of photorefractive keratectomy (PRK)

Hegarty, D. M.; Carroll, J. R.; Nguyen, D.; Halls, V. S.; Robbins, D. I.; Price, T. J.; Dussor, G.; Aicher, S. A.

10.1101/2022.01.25.477730 — neuroscience — Posted on 2022-01-28

357 Encoding and decoding analysis of music perception using intracranial EEG

Bellier, L.; Llorens, A.; Marciano, D.; Schalk, G.; Brunner, P.; Knight, R. T.; Pasley, B. N.

10.1101/2022.01.27.478085 — neuroscience — Posted on 2022-01-28

358 Anterior insular cortex inputs to the dorsolateral striatum govern the maintenance of binge alcohol drinking

Haggerty, D. L.; Munoz, B.; Pennington, T.; Grecco, G. G.; Atwood, B.

10.1101/2022.01.27.478049 — neuroscience — Posted on 2022-01-28

359 Predicting the Degree of Distracted Driving Based on fNIRS Functional Connectivity: A Pilot Study

Ogihara, T.; Tanioka, K.; Hiroyasu, T.; Hiwa, S.

10.1101/2022.01.25.477783 — neuroscience — Posted on 2022-01-28

360 Widespread alterations in microRNA biogenesis in human Huntington's disease putamen

Petry, S.; Keraudren, R.; Nateghi, B.; Loiselle, A.; Pircs, K.; Jakobsson, J. S.; Sephton, C.; Langlois, M.; St-Amour, I.; Hebert, S. S.

10.1101/2022.01.27.478047 — neuroscience — Posted on 2022-01-28

361 Decoding the temporal dynamics of affective scene processing

Bo, K.; Cui, L.; Yin, S.; Hu, Z.; Hong, X.; Kim, S.; Keil, A.; Ding, M.

10.1101/2022.01.27.478067 — neuroscience — Posted on 2022-01-28

362 Position- and scale-invariant object-centered spatial selectivity in monkey frontoparietal cortex dynamically adapts to task demand

Taghizadeh, B.; Fortmann, O.; Gail, A.

10.1101/2022.01.26.477941 — neuroscience — Posted on 2022-01-28

363 The thresholding problem and variability in the EEG graph network parameters

Adamovich, T.; Zakharov, I.; Tabueva, A.; Malykh, S.

10.1101/2022.01.26.477863 — neuroscience — Posted on 2022-01-28

364 Fast and accurate joint inference of coancestry parameters for populations and/or individuals

Mary-Huard, T.; Balding, D.

10.1101/2022.01.28.478138 — genetics — Posted on 2022-01-28

365 Antagonistic regulation of Drosophila mitochondrial uncoupling protein UCP4b by cold and BMP signaling

Chatterjee, N.; Song, W.; Dumesic, P.; Spiegelman, B.; Perrimon, N.

10.1101/2022.01.27.477603 — genetics — Posted on 2022-01-28

366 The histone code of the fungal genus Aspergillus uncovered by evolutionary and proteomic analyses

Zhang, X.; Noberini, R.; Bonaldi, T.; Collemare, J.; Seidl, M. F.

10.1101/2022.01.28.477868 — evolutionary biology — Posted on 2022-01-28

367 The genomic basis of the plant island syndrome in Darwin's giant daisies

Cerca, J.; Petersen, B.; Lazaro Guevara, J. M.; Rivera-Colon, A.; Birkeland, S.; Vizueta, J.; Li, S.; Loureiro, J.; Kosawang, C.; Jaramillo Diaz, P.; Rivas-Torres, G.; Fernandez-Mazuecos, M.; Vargas, P.; McCauley, R.; Petersen, G.; Santos-Bay, L.; Wales, N.; Catchen, J.; Machado, D.; D. Nowak, M.; Suh, A.; Sinha, N.; Nielsen, L. R.; Seeberg, O.; P. Gilbert, M. T.; Leebens-Mack, J. H.; Rieseberg, L.; Martin, M. D.

10.1101/2022.01.26.477903 — evolutionary biology — Posted on 2022-01-28

368 Common and lifestyle-specific traits of mycorrhiza-associated metabolite alterations in plant roots reflects strategies of root-mycorrhizal interactions

Xia, M.; Suseela, V.; McCormack, M. L.; Kennedy, P.; Tharayil, N.

10.1101/2022.01.27.478019 — ecology — Posted on 2022-01-28

369 The Vibrio vulnificus stressosome is dispensable in nutrient-replete conditions.

Cutugno, L.; Mc Cafferty, J.; Pane-Farre, J.; O'Byrne, C. P.; Boyd, A.

10.1101/2022.01.27.477717 — microbiology — Posted on 2022-01-28

370 mucG, mucH,and mucI modulate production of mutanocyclin and reutericyclins in Streptococcus mutans B04Sm5

Baker, J. L.; Tang, X.; LaBonte, S. A.; Uranga, C. C.; Edlund, A.

10.1101/2022.01.27.478122 — microbiology — Posted on 2022-01-28

371 WAT3R: Recovery of T-Cell Receptor Variable Regions From 3' Single-Cell RNA-Sequencing

Ainciburu, M.; Morgan, D. M.; DePasquale, E. A. K.; Love, J. C.; Prosper, F.; van Galen, P.

10.1101/2022.01.26.477886 — immunology — Posted on 2022-01-28

372 Existence of blood circulating immune-cell clusters (CICs) comprising antigen-presenting cells and B cells

Bae, S.; Lee, Y.; Kang, M.; Noh, J.; Seo, D.; Seo, H.; Lee, S.; Kwon, S.

10.1101/2022.01.26.477834 — immunology — Posted on 2022-01-28

373 Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

Li, D.; Martinez, D. R.; Schäfer, A.; Chen, H.; Barr, M.; Sutherland, L. L.; Lee, E.; Parks, R.; Mielke, D.; Edwards, W.; Newman, A.; Bock, K. W.; Minai, M.; Nagata, B. M.; Gagne, M.; Douek, D.; DeMarco, C. T.; Denny, T. N.; Oguin, T. H.; Rountree, W.; Wang, Y.; Mansouri, K.; Edwards, R. J.; Ferrari, G.; Sempowski, G. D.; Eaton, A.; Tang, J.; Cain, D. W.; Santra, S.; Pardi, N.; Weissman, D.; Tomai, M.; Fox, C.; Moore, I. N.; Andersen, H.; Lewis, M. G.; Golding, H.; Khurana, S.; Seder, R.; Baric, R. S.; Montefiori, D. C.; Saunders, K. O.; Haynes, B. F.

10.1101/2022.01.26.477915 — immunology — Posted on 2022-01-28

374 Nucleoside reverse transcriptase inhibitors are the major class of HIV antiretroviral therapeutics that induce neuropathic pain in Mice

Bush, K.; Wairkar, Y.; Tang, S.-J.

10.1101/2022.01.27.478061 — neuroscience — Posted on 2022-01-28

375 INFLAMMATORY BOWEL DISEASE INDUCES α-SYNUCLEIN AGGREGATION IN GUT AND BRAIN

Espinosa-Oliva, A. M.; Laza, R. R.; Soto, M. S.; Serrano, A. B.; Perez, A. I. R.; Ceballos, M. A. R.; Revilla, J. G.; Pavon, M. S.; Serres, S.; Economopoulus, V.; Vazquez, A. E. C.; Carretero, M. D. V.; Miranda, P. G.; Klementieva, O.; Martin, M. J. O.; Deierborg, T.; Infante, E. R.; Sibson, N. R.; Garcia, J. L. L.; de la Quintana, A. M.; Rubio, M. J. P.; Carmona, A. J. H.; Recio, J. L. V.; de Pablos, R. M.

10.1101/2022.01.26.477259 — neuroscience — Posted on 2022-01-28

376 Differential cellular stiffness contributes to tissue elongation on an expanding surface

Koyama, H.; Suzuki, M.; Yasue, N.; Sasaki, H.; Ueno, N.; Fujimori, T.

10.1101/2022.01.27.478117 — biophysics — Posted on 2022-01-28

377 TissUUmaps 3: Interactive visualization and quality assessment of large-scale spatial omics data

Pielawski, N.; Andersson, A.; Avenel, C.; Behanova, A.; Chelebian, E.; Klemm, A.; Nysjö, F.; Solorzano, L.; Wählby, C.

10.1101/2022.01.28.478131 — bioinformatics — Posted on 2022-01-28

378 What stabilizes pre-folded structures in the intrinsically disordered α-helical binding motifs?

Hadzi, S.; Puric, S.; Zavrtanik, U.; Vranken, W.

10.1101/2022.01.28.478151 — bioinformatics — Posted on 2022-01-28

379 LmTag: functional-enrichment and imputation-aware tag SNP selection for population-specific genotyping arrays

Nguyen, D. T.; Nguyen, Q.; Nguyen, D. T.; Vo, N. S.

10.1101/2022.01.28.478108 — bioinformatics — Posted on 2022-01-28

380 STORM: spectral sparsification helps restore the spatial structure at single-cell resolution

WANG, J.; Li, S.; Chen, L.; Li, S.

10.1101/2022.01.25.477389 — bioinformatics — Posted on 2022-01-28

381 Self-assembled DNA nanostructures promote cell migration & differentiation of human umbilical vein endothelial cells

Rajwar Gada, A.; Vaswani, P.; Bhatia, D. D.

10.1101/2022.01.28.478149 — bioengineering — Posted on 2022-01-28

382 Structures of the Type IX Secretion/gliding motility motor from across the phylum Bacteroidetes

Hennell James, R.; Deme, J. C.; Hunter, A.; Berks, B. C.; Lea, S. M.

10.1101/2022.01.28.478170 — biochemistry — Posted on 2022-01-28

383 Inducible degradation of dosage compensation protein DPY-27 facilitates isolation of Caenorhabditis elegans males for molecular and biochemical analyses

Engebrecht, J.; Li, Q.; Kaur, A.; Mallory, B.; Hariri, S.

10.1101/2022.01.27.478040 — genetics — Posted on 2022-01-28

384 Genetic characterization of ABC pesticide transporters establishes Drosophila as an in vivo model for toxicogenetics

Denecke, S. M.; Luong, H. N. B.; Koidou, V.; Kalogeridi, M.; Socratous, R.; Howe, S.; Vogelsang, K.; Nauen, R.; Batterham, P.; Geibel, S.; Vontas, J.

10.1101/2022.01.27.477983 — genetics — Posted on 2022-01-28

385 Did Caenorhabditis nematodes recycle transposons to fight pathogens?

Li, Z.; Roedelsperger, C.

10.1101/2022.01.28.478163 — evolutionary biology — Posted on 2022-01-28

386 The limits of metabolic heredity in protocells

Nunes Palmeira, R.; Colnaghi, M.; Harrison, S. A.; Pomiankowski, A.; Lane, N.

10.1101/2022.01.28.477904 — evolutionary biology — Posted on 2022-01-28

387 Spatial and molecular anatomy of germ layers in the gastrulating primate embryo

Cui, G.; Feng, S.; Yan, Y.; Wang, L.; He, X.; Li, X.; Duan, Y.; Chen, J.; Tam, P. P. L.; Tang, K.; Zheng, P.; Si, W.; Jing, N.; Peng, G.

10.1101/2022.01.26.474719 — developmental biology — Posted on 2022-01-28

388 Preclinical stage abundance and nuclear antigen reactivity of fecal Immunoglobulin A (IgA) varies among males and females of lupus-prone mouse models

Gudi, R.; Roy, S.; Sun, W.; Vasu, C.

10.1101/2022.01.26.477917 — immunology — Posted on 2022-01-28

389 RNase L-mediated RNA decay alters 3' end formation and splicing of host mRNAs

Burke, J. M.; Ripin, N.; Ferretti, M. B.; St Clair, L. A.; Worden-Sapper, E. R.; Sawyer, S. L.; Perera, R.; Lynch, K. W.; Parker, R.

10.1101/2022.01.28.478180 — immunology — Posted on 2022-01-28

390 Changes in cellular ferritin distribution of human brain tissue during autolysis revealed using analytical electron microscopy

Sunkara, S.; Radulovic, S.; Lipovsek, S.; Birkl, C.; Eggenreich, S.; Birkl-Toeglhofer, A. M.; Schinagl, M.; Funk, D.; Stoeger-Pollach, M.; Haybaeck, J.; Goessler, W.; Ropele, S.; Leitinger, G.

10.1101/2022.01.26.477869 — neuroscience — Posted on 2022-01-28

391 Multisensory information about changing object properties can be used to quickly correct predictive force scaling for object lifting

van Polanen, V.

10.1101/2022.01.26.477825 — neuroscience — Posted on 2022-01-28

392 Inter-animal variability in activity phase is constrained by synaptic dynamics in an oscillatory network

Anwar, H.; Martinez, D.; Bucher, D.; Nadim, F.

10.1101/2022.01.27.478028 — neuroscience — Posted on 2022-01-28

393 The role of preterm birth and postnatal stress in neonatal structural brain development

Lammertink, F.; Benders, M. J. N. L.; Hermans, E. J.; Tataranno, M. L.; Dudink, J.; Vinkers, C. H.; van den Heuvel, M. P.

10.1101/2022.01.28.478158 — neuroscience — Posted on 2022-01-28

394 Allatotropin in the Corpora Allata and Ovaries of Rhodnius prolixus: Probable in situ regulatory mechanisms

Villalobos Sambucaro, M. J.; Ronderos, J. R.

10.1101/2022.01.27.478009 — zoology — Posted on 2022-01-28

395 Building model prototypes from time-course data

Veliz-Cuba, A.; Voss, R.; Murrugarra, D.

10.1101/2022.01.27.478080 — systems biology — Posted on 2022-01-28

396 A Statistical Physics Approach for Disease Module Detection

Wang, X.-W.; Qiao, D.; Cho, M.; DeMeo, D.; Silverman, E. K.; Liu, Y.-Y.

10.1101/2022.01.26.477756 — systems biology — Posted on 2022-01-28

397 Temporal Optimization of Radiation Therapy to Heterogeneous Tumour Populations and Cancer Stem Cells

Meaney, C.; Kohandel, M.; Novruzi, A.

10.1101/2022.01.26.477741 — systems biology — Posted on 2022-01-28

398 Compartment-specific energy requirements of photosynthetic carbon metabolism in Camelina sativa leaves

Wieloch, T.; Sharkey, T. D.

10.1101/2022.01.28.478172 — plant biology — Posted on 2022-01-28

399 A wheat kinase and immune receptor form the host-specificity barrier against the blast fungus

Arora, S.; Steed, A.; Goddard, R.; Gaurav, K.; O'Hara, T.; Schoen, A.; Rawat, N.; Elkot, A. F.; Chinoy, C.; Nicholson, M. H.; Asuke, S.; Steuernagel, B.; Yu, G.; Awal, R.; Forner-Martinez, M.; Wingen, L.; Baggs, E.; Clarke, J.; Krasileva, K. V.; Tosa, Y.; Jones, J. D. G.; Tiwari, V. K.; Wulff, B. B. H.; Nicholson, P.

10.1101/2022.01.27.477927 — plant biology — Posted on 2022-01-28

400 Knockout of OsSWEET15 impaired rice embryo formation and seed-setting

Hu, Y.; Tang, Z.; Yang, J.; Bao, S.; Hu, Z.; Xia, H.; Ma, L.; Zheng, Q.; Yang, F.; Zhang, D.; Wang, T.; Sun, S.

10.1101/2022.01.27.478039 — plant biology — Posted on 2022-01-28

401 Genetic basis and adaptive implications of temperature-dependent and temperature-independent effects of drought on chickpea phenology

Li, Y.; Lake, L.; Chauhan, Y. S.; Taylor, J.; Sadras, V.

10.1101/2022.01.26.477940 — plant biology — Posted on 2022-01-28

402 The phloem-resident protein OCTOPUS is a novel regulator of flg22-induced responses in Arabidopsis thaliana

Greenwood, K. N.; King, C. L.; Melena, I.; Stegemann, K. A.; Collins, C. A.

10.1101/2022.01.27.478095 — plant biology — Posted on 2022-01-28

403 Arabidopsis CONSERVED BINDING OF EIF4E1 negatively regulates the NADPH oxidase RESPIRATORY BURST OXIDASE HOMOLOG D

George, J.; Stegmann, M.; Monaghan, J.; Zipfel, C.

10.1101/2022.01.27.478037 — plant biology — Posted on 2022-01-28

404 Temperature modulates PVN pre-sympathetic neurones via transient receptor potential ion channels.

OBrien, F. M.; Feetham, C.; Caroline, C. A.; Hext, K.; Barrett-Jolley, R.

10.1101/2022.01.26.477880 — physiology — Posted on 2022-01-28

405 3D Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast

Lewis, R.; Baskaran, H.; Green, J.; Tashev, S.; Palaiologou, E.; Lofthouse, E. M.; Cleal, J. K.; Page, A.; Chatelet, D.; Goggin, P.; Sengers, B. G.

10.1101/2022.01.26.477815 — physiology — Posted on 2022-01-28

406 Heterotrimeric G protein α subunit (GPA1) regulates the response to low-nitrogen stress in Arabidopsis by interacting with AtNRT1.4 and AtATG8a

Luo, M.; Hu, L.; Li, W.; Ge, L.; Qin, Y.; Zhou, Y.; Tang, W.; Wang, C.; Xu, Z.-S.; Delaplace, P.; Ma, Y.-z.; Chen, M.; Chen, J.

10.1101/2022.01.27.478073 — physiology — Posted on 2022-01-28

407 Deletion of Sod1 in motor neurons exacerbates age-related changes in axons and NMJs associated with premature muscle atrophy in aging mice

Pollock, N.; Macpherson, P. C.; Staunton, C. A.; Hemmings, K.; Davis, C. S.; Owen, E. D.; Vasilaki, A.; Van Remmen, H.; Richardson, A.; McArdle, A.; Brooks, S. V.; Jackson, M. J.

10.1101/2022.01.27.477840 — physiology — Posted on 2022-01-28

408 Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β.

Kobro-Flatmoen, A.; Battistin, C.; Raveendran, R. N.; Bjorkli, C.; Skender, B.; Kentros, C.; Gouras, G. K.; Witter, M. P.

10.1101/2022.01.28.478143 — pathology — Posted on 2022-01-28

409 Single-Cell Analysis Identifies Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension

Viswanathan, G.; Kirshner, H. F.; Nazo, N.; Ganapathi, A.; Cumming, I.; Warman, A.; Almeida-Peters, S.; Haney, J.; Corcoran, D.; Yu, Y.-R. A.; Rajagopal, S.

10.1101/2022.01.26.477878 — pathology — Posted on 2022-01-28

410 How to use transcriptomic data for game-theoretic modeling of treatment-induced resistance in cancer cells?A case study in patient-derived glioblastoma organoids

Gaska, W.; Lokh, C.; Verduin, M.; Vooijs, M.; Cavill, R.; Stankova, K.

10.1101/2022.01.26.477755 — cancer biology — Posted on 2022-01-28

411 Comparative study of the effect of neutrons emitted from neutron source 241Am-Be and curcumin on MCF-7 breast cancer cells in 3D culture medium

Zargan, S.; Salehi Barough, M.; Zargan, J.; Shayesteh, M.; Mousavi, M.; Keshavarz, H.; Haji Nor Mohamadi, A.

10.1101/2022.01.25.477792 — biophysics — Posted on 2022-01-28

412 HydrAMP: a deep generative model for antimicrobial peptide discovery

Szymczak, P.; Mozejko, M.; Grzegorzek, T.; Bauer, M.; Neubauer, D.; Michalski, M.; Sroka, J.; Setny, P.; Kamysz, W.; Szczurek, E.

10.1101/2022.01.27.478054 — bioinformatics — Posted on 2022-01-28

413 Generation of stable microtubule superstructures by binding of peptide-fused tetrameric proteins to inside and outside

Inaba, H.; Sueki, Y.; Ichikawa, M.; Kabir, A. M. R.; Iwasaki, T.; Shigematsu, H.; Kakugo, A.; Sada, K.; Matsuura, K.

10.1101/2022.01.27.476107 — bioengineering — Posted on 2022-01-28

414 Topology of connective tissues: a key parameter in cellular heterogeneity, beyond composition and stiffness

Chen, C.; Ibrahim, Z.; Marchand, M. F.; Piolot, T.; Kamboj, S.; Carreiras, F.; Yamada, A.; Schanne Klein, M. C.; Chen, Y.; Lambert, A.; Aime, C.

10.1101/2022.01.26.477902 — bioengineering — Posted on 2022-01-28

415 Blood flow modeling under LVAD physiology. From global circulation to local hemodynamics

Blanco, P. J.; Grinstein, J.; Bulant, C. A.; Torii, R.; Bourantas, C.; Lemos, P.; Garcia-Garcia, H.

10.1101/2022.01.28.478161 — bioengineering — Posted on 2022-01-28

416 Bio-inspired artificial printed bioelectronic cardio-3D-cellular constructs

Sanjuan Alberte, P.; Charlie Whitehead, C.; Jones, J.; Silva, J. C.; Carter, N.; Kellaway, S.; Ferreira, F. C.; Hague, R. J. M.; Cabral, J. M. S.; White, L. J.; Rawson, F. J.

10.1101/2022.01.26.477866 — bioengineering — Posted on 2022-01-28

417 Megaviruses contain various genes encoding for eukaryotic vesicle trafficking factors

Neveu, E.; Kalifeh, D.; Fasshauer, D.

10.1101/2022.01.28.478187 — genomics — Posted on 2022-01-28

418 Validation of SNP markers for marker-assisted selection of genotypes with increased carotenoid and dry matter contents in cassava

Ige, A. D.; Olasanmi, B.; Bauchet, G.; Kayondo, I. S.; Mbanjo-Edwige, G.-N.; Uwugiaren, R.; Motomura-Wages, S.; Norton, J.; Egesi, C.; Parkes, E. Y.; Kulakow, P.; Ceballos, H.; Rabbi, I. Y.

10.1101/2022.01.27.478005 — genomics — Posted on 2022-01-28

419 Genomic and phylogenetic analysis of the first myovirus isolated from Oceanospirillaceae, representing a novel viral cluster prevalent in polar oceans

Zhang, W.; Liu, Y.; Xing, J.; Zheng, K.; Li, Q.; Gu, C.; Wang, Z.; Shao, H.; Guo, C.; He, H.; Wang, H.; Sung, Y. Y.; Mok, W. J.; Wong, L. L.; Liang, Y.; Wang, M.; McMinn, A.

10.1101/2022.01.27.478124 — genomics — Posted on 2022-01-28

420 A chromosome-level, fully phased genome assembly of the oat crown rust fungus Puccinia coronata f. sp. avenae: a resource to enable comparative genomics in the cereal rusts

Henningsen, E. C.; Hewitt, T.; Dugyala, S.; Nazareno, E.; Gilbert, E.; Li, F.; Kianian, S.; Steffenson, B. J.; Dodds, P. N.; Sperschneider, J.; Figueroa, M.

10.1101/2022.01.26.477636 — genomics — Posted on 2022-01-28

421 Genetic modifiers of Cep290-mediated retinal degeneration

Meyer, K. J.; Whitmore, S. S.; Burnight, E. R.; Riker, M.; Mercer, H. E.; Oladele-Ajose, A.; Howell, G.; Stone, E. M.; Mullins, R. F.; Tucker, B. A.; Scheetz, T. E.; Anderson, M. G.

10.1101/2022.01.26.477596 — genetics — Posted on 2022-01-28

422 Extensive retargeting of plant aminoacyl tRNA synthetases correlates with mitochondrial tRNA gene loss

Warren, J. M.; Sloan, D. B.

10.1101/2022.01.27.478071 — evolutionary biology — Posted on 2022-01-28

423 Fitness costs and benefits in response to artificial artesunate selection in Plasmodium

Villa, M.; Berthomieu, A.; Rivero, A.

10.1101/2022.01.28.478164 — evolutionary biology — Posted on 2022-01-28

424 Experimental disruption of social structure reveals totipotency in the orchid bee, Euglossa dilemma

Saleh, N. W.; Henske, J.; Ramirez, S. R.

10.1101/2022.01.27.478072 — evolutionary biology — Posted on 2022-01-28

425 Geographical and ecological drivers of coexistence dynamics in squamate reptiles

Alencar, L.; Quental, T.

10.1101/2022.01.27.478006 — evolutionary biology — Posted on 2022-01-28

426 Soil fungal communities vary more with soil characteristics than tree diversity at a local scale

Kutos, S.; Barnes, E.; Lewis, J.

10.1101/2022.01.26.477882 — ecology — Posted on 2022-01-28

427 Characterization of Cyanobacterial Communities in Lakes Requires Consideration of Diurnal and Spatial Variation

Cameron, E. S.; Emelko, M. B.; Müller, K. M.

10.1101/2022.01.27.478008 — ecology — Posted on 2022-01-28

428 Slower organisms exhibit sudden population disappearances in a reddened world

Greyson-Gaito, C. J.; Gellner, G.; McCann, K. S.

10.1101/2022.01.27.478031 — ecology — Posted on 2022-01-28

429 Extinction risk, reconstructed catches, and management of chondrichthyan fishes in the Western Central Atlantic Ocean

Talwar, B. S.; Anderson, B.; Avalos-Castillo, C. G.; Blanco-Parra, M. d. P.; Briones, A.; Cardenosa, D.; Carlson, J. K.; Charvet, P.; Cotton, C. F.; Crysler, Z.; Derrick, D. H.; Heithaus, M. R.; Herman, K. B.; Koubrak, O.; Kulka, D. W.; Kyne, P. M.; Lasso-Alcala, O. M.; Mejia-Falla, P. A.; Morales-Saldana, J. M.; Naranjo-Elizondo, B.; Navia, A. F.; Pacoureau, N.; Perez-Jimenez, J. C.; Pollom, R. A.; Rigby, C. L.; Schneider, E. V.; Simpson, N.; Dulvy, N. K.

10.1101/2022.01.26.477854 — ecology — Posted on 2022-01-28

430 CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism

Slavi, N.; Balasubramanian, R.; Lee, M. A.; Liapin, M.; Oaks-Leaf, R.; Peregrin, J.; Potenski, A.; Troy, C. M.; Ross, M. E.; Herrera, E.; Kosmidis, S.; John, S. W. M.; Mason, C. A.

10.1101/2022.01.27.477954 — developmental biology — Posted on 2022-01-28

431 Fgfr2b signaling is essential for the maintenance of the alveolar epithelial type 2 lineage during lung homeostasis in mice

Ahmadvand, N.; Lingampally, A.; Khosravi, F.; Vazquez-Armendariz, A.; Rivetti, S.; Wilhelm, J.; Herold, S.; Barreto, G.; Koepke, J.; Samakovlis, C.; Carraro, G.; Zhang, J.; Al Alam, D.; Bellusci, S.

10.1101/2022.01.26.477823 — developmental biology — Posted on 2022-01-28

432 CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

Prieto, S.; Dubra, G.; Camasses, A.; Simboeck, E.; Aznar, A. B.; Begon-Pescia, C.; Pirot, N.; Gerbe, F.; Angevin, L.; Jay, P.; Krasinska, L.; Fisher, D.

10.1101/2022.01.28.478171 — cell biology — Posted on 2022-01-28

433 LuminoCell: a versatile and affordable luminometer platform for monitoring in-cell luciferase-based reporters

Weissova, K.; Fafilek, B.; Radaszkiewicz, T.; Celiker, C.; Machackova, P.; Cechova, T.; Sebestikova, J.; Hampl, A.; Bryja, V.; Krejci, P.; Barta, T.

10.1101/2022.01.28.478134 — molecular biology — Posted on 2022-01-28

434 Aeromonas hydrophila induces skin disturbance through mucosal microbiota dysbiosis in Pangasianodon hypophthalmus

CHEN, L. H.; LIN, C. H.; SIAO, R. F.; Wang, L.-C.

10.1101/2022.01.27.478127 — microbiology — Posted on 2022-01-28

435 PD-L1 blockade restores CAR T cell activity through IFNγ-regulation of CD163+ macrophages

Yamaguchi, Y.; Gibson, J.; Ou, K.; Ng, R. H.; Jonsson, V. D.; Zarif, J. C.; Lee, P. P.; Wang, X.; Martinez, C.; Dorff, T. B.; Forman, S. J.; Priceman, S. J.

10.1101/2022.01.25.477150 — immunology — Posted on 2022-01-28

436 Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal anti-tumor immunity

Choi, Y.; Gao, Y.; Coughlin, L.; Poulides, N.; Kim, J.; Zhan, X.; Hooper, L.; Pasare, C.; Koh, A.

10.1101/2022.01.26.477865 — immunology — Posted on 2022-01-28

437 Reprogramming Alveolar Macrophage Responses to TGF-β Reveals CCR2+ Monocyte Activity that Promotes Bronchiolitis Obliterans Syndrome

Liu, Z.; Liao, F.; Zhu, J.; Zhou, D.; Heo, G. S.; Luehmann, H. P.; Scozzi, D.; Parks, A.; Hachem, R.; Byers, D.; Tague, L. K.; Kulkarni, H. S.; Cano, M.; Wong, B. W.; Li, W.; Huang, H. J.; Krupnick, A. S.; Kreisel, D.; Liu, Y.; Gelman, A. E.

10.1101/2022.01.27.478090 — immunology — Posted on 2022-01-28

438 Design and Characterization of Lipid Nanocarriers for Oral Delivery of Immunotherapeutic Peptides

Calderon Colon, X.; Zhang, Y.; Tiburzi, O.; Wang, J.; Raimondi, G.; Patrone, J.

10.1101/2022.01.27.478027 — immunology — Posted on 2022-01-28

439 Gnas ablation in CD11c+ cells prevents high-fat diet-induced obesity by elevating adipose tissue catecholamine levels and thermogenesis

Zeng, L.; Herdman, D. S.; Lee, J.; Tao, A.; Das, M.; Bertin, S.; Eckmann, L.; Mahata, S. K.; Devulapalli, S.; Patel, H.; Molina, A. J. A.; Osborn, O.; Corr, M.; Raz, E.; Webster, N. J. G.

10.1101/2022.01.27.478070 — immunology — Posted on 2022-01-28

440 In silico transcriptomics identifies FDA-approved drugs and biological pathways for protection against cisplatin-induced hearing loss

Salehi, P.; Zallocchi, M.; Vijayakumar, S.; Urbanek, M.; Giffen, K. P.; Li, Y.; Hati, S.; Zuo, J.

10.1101/2022.01.26.477836 — neuroscience — Posted on 2022-01-28

441 Sampling-based Bayesian inference in recurrent circuits of stochastic spiking neurons

Zhang, W.; Wu, S.; Josic, K.; Doiron, B.

10.1101/2022.01.26.477877 — neuroscience — Posted on 2022-01-28

442 Unified surface and volumetric projection of physiological imaging data

Kirk, T.; Craig, M.; Chappell, M.

10.1101/2022.01.28.477071 — neuroscience — Posted on 2022-01-28

443 Automated Human Habenula Segmentation from T1-weighted Magnetic Resonance Images using V-Net

Kim, J.-w.; Xu, J.

10.1101/2022.01.25.477768 — neuroscience — Posted on 2022-01-28

444 Multiscale Entropy Analysis of Retinal Signals Reveals Reduced Complexity in a Mouse Model of Alzheimer's Disease

Araya-Arriagada, J.; Garay, S.; Rojas, C.; Duran-Aniotz, C.; G. Palacios, A.; Chacon, M.; E. Medina, L.

10.1101/2022.01.27.478055 — neuroscience — Posted on 2022-01-28

445 A Guide for Quantifying and Optimizing Measurement Reliability for the Study of Individual Differences

Xu, T.; Cho, J.; Kiar, G.; Bridgeford, E. W.; Vogelstein, J. T.; Milham, M. P.

10.1101/2022.01.27.478100 — neuroscience — Posted on 2022-01-28

446 Role of posterodorsal medial amygdala kisspeptin and urocortin-3 in pubertal timing in female mice

Ivanova, D.; Li, X.; Liu, Y.; Mcintyre, C.; Fernandes, C.; Lass, G.; Kong, L.; O'Byrne, K.

10.1101/2022.01.27.477996 — neuroscience — Posted on 2022-01-28

447 Acute Axon Damage and Demyelination are Mitigated by 4-Aminopyridine (4-AP) Therapy after Experimental Traumatic Brain Injury

Radomski, K. L.; Zi, X.; Lischka, F. W.; Noble, M. D.; Galdzicki, Z.; Armstrong, R. C.

10.1101/2022.01.27.477989 — neuroscience — Posted on 2022-01-28

448 Multiple Synaptic Contacts combined with Dendritic Filtering enhance Spatio-Temporal Pattern Recognition capabilities of Single Neurons

Beniaguev, D.; Segev, I.; London, M.

10.1101/2022.01.28.478132 — neuroscience — Posted on 2022-01-28

449 Mindin is essential for cutaneous fibrogenesis in a new mouse model of systemic sclerosis

Rana, I.; Kataria, S.; Tan, T.-L.; Hajam, E. Y.; Kashyap, D. K.; Saha, D.; Ajnabi, J.; Paul, S.; Jayappa, S.; Ananthan, A. S.; Kumar, P.; Zaarour, R. F.; J, H.; Samuel, R.; George, R.; Danda, D.; Jacob, P. M.; Dey, R.; Perundurai, D.; He, Y.-W.; Varga, J.; Varghese, S.; Jamora, C.

10.1101/2022.01.26.477822 — pathology — Posted on 2022-01-28

450 Steroidogenic factor-1 lineage origin of skin lesions in Carney complex syndrome

Sahut-Barnola, I.; Lefrancois-Martinez, A. M.; Dufour, D.; Botto, J.-M.; Kamilaris, C.; Faucz, F. R.; Stratakis, C. A.; Val, P.; Martinez, A.

10.1101/2022.01.26.477839 — pathology — Posted on 2022-01-28

451 Effective generation of tumor-infiltrating lymphocyte products from metastatic non-small-cell lung cancer (NSCLC) lesions irrespective of location and previous treatments.

Castenmiller, S. M.; de Groot, R.; Guislain, A.; Monkhorst, K.; Hartemink, K. J.; Veenhof, A. A. F. A.; Smit, E. F.; Haanen, J. B. A. G.; Wolkers, M. C.

10.1101/2022.01.28.478173 — cancer biology — Posted on 2022-01-28

452 Design in the DARK: Learning Deep Generative Models for De Novo Protein Design

Moffat, L.; Kandathil, S. M.; Jones, D. T.

10.1101/2022.01.27.478087 — bioinformatics — Posted on 2022-01-28

453 Accurate strain-level microbiome composition analysis from short reads

Liao, H.; Ji, Y.; Sun, Y.

10.1101/2022.01.26.477962 — bioinformatics — Posted on 2022-01-28

454 The computational models of AlphaFold2 and RoseTTAfold carry protein foldability information

Liu, S.; Wu, K.; Chen, C.

10.1101/2022.01.27.477978 — bioinformatics — Posted on 2022-01-28

455 Power analysis for spatial omics

Baker, E. A. G.; Schapiro, D.; Dumitrascu, B.; Vickovic, S.; Regev, A.

10.1101/2022.01.26.477748 — bioinformatics — Posted on 2022-01-28

456 Methacrylate-Modified Gold Nanoparticles Enable Non-Invasive Monitoring of Photocrosslinked Hydrogel Scaffolds

Li, L.; Gil, C. J.; Finamore, T. A.; Evans, C. J.; Tomov, M. L.; Ning, L.; Theus, A.; Kabboul, G.; Serpooshan, V.; Roeder, R. K.

10.1101/2022.01.26.477960 — bioengineering — Posted on 2022-01-28

457 Rapid deep widefield neuron finder driven by virtual calcium imaging data

Zhang, Y.; Zhang, G.; Han, X.; Wu, J.; Li, Z.; Li, X.; Xiao, G.; Xie, H.; Fang, L.; Dai, Q.

10.1101/2022.01.25.474600 — bioengineering — Posted on 2022-01-28

458 RTEL1 and MCM10 overcome topological stress during vertebrate replication termination

Campos, L. V.; Greer, B. H.; Heintzman, D. R.; Kavlashvili, T.; McDonald, W. H.; Rose, K. L.; Eichman, B. F.; Dewar, J. M.

10.1101/2022.01.27.478093 — biochemistry — Posted on 2022-01-28

459 Protein Refolding Guided by High-Throughput Differential Scanning Fluorimetry: a case study of an HtrA-Family Bacterial Protease

Ronzetti, M. H.; Baljinnyam, B.; Simeonov, A.

10.1101/2022.01.27.477556 — biochemistry — Posted on 2022-01-28

460 Elucidating Heterogeneous Iron Biomineralization Patterns in a Denitrifying As(III)-Oxidizing Bacterium: Implications for Arsenic Immobilization

Lopez-Adams, R.; Fairclough, S. M.; Lyon, I. C.; Haigh, S. J.; Zhang, J.; Zhao, F.-J.; Moore, K. L.; Lloyd, J. R.

10.1101/2022.01.28.478188 — biochemistry — Posted on 2022-01-28

461 Age and experience affect the biosynthesis and emission of a Drosophila pheromone

Cortot, J.; Farine, J.-P.; Cobb, M.; Everaerts, C.; Ferveur, J.-F.

10.1101/2022.01.27.478004 — animal behavior and cognition — Posted on 2022-01-28

462 Selective Ablation of 3' RNA ends and Processive RTs Facilitate Direct cDNA Sequencing of Full-length Host cell and Viral Transcripts

Gallardo, C. M.; Nguyen, A.-V. T.; Routh, A. L.; Torbett, B. E.

10.1101/2022.01.27.478099 — genomics — Posted on 2022-01-28

463 Identifying systematic variation at the single-cell level by leveraging low-resolution population-level data

Rahmani, E.; Jordan, M. I.; Yosef, N.

10.1101/2022.01.27.478115 — genomics — Posted on 2022-01-28

464 Automated phenol-chloroform extraction of high molecular weight genomic DNA for use in long-read single-molecule sequencing.

Liu, A. W.; Villar-Briones, A.; Luscombe, N. M.; Plessy, C.

10.1101/2022.01.26.477939 — genomics — Posted on 2022-01-28

465 DiSCs: Domains involving SETDB1 and Cohesin are critical regulators of genome topology and stem cell fate

Warrier, T.; Farran, C. E.; Zeng, Y.; Ho, B. S. Q.; Xu, D. L.; Bao, Q.; Zheng, Z. H.; Bi, X.; Tan, K. Y. S.; Ng, H.-H.; Ong, D. S. T.; Chu, J. J. H.; Sanyal, A.; Fullwood, M. J.; Collins, J.; Li, H.; Xu, J.; Loh, Y. H.

10.1101/2022.01.27.478011 — genomics — Posted on 2022-01-28

466 De novo transcriptome of Taverniera cuneifolia (Roth) Ali.

Momin, T.; Punvar, A.; Zala, H.; Ayachit, G.; Joshi, M.; Nagar, P. S.

10.1101/2022.01.27.477879 — genomics — Posted on 2022-01-28

467 Tissue-specific and repeat length-dependent somatic instability of the X-linked dystonia parkinsonism-associated CCCTCT repeat

Campion, L. N.; Yadav, R.; Penney, E. B.; Murcar, M. G.; Correia, K.; Gillis, T.; Fernandez-Cerado, C.; Velasco-Andrada, M. S.; Legarda, G. P.; Ganza-Bautista, N. G.; Lagarde, J. B. B.; Acuña, P. J.; Multhaupt-Buell, T.; Aldykiewicz, G.; Supnet, M. L.; DeGuzman, J. K.; Go, C.; Sharma, N.; Munoz, E. L.; Ang, M. C.; Diesta, C. C. E.; Bragg, D. C.; Ozelius, L. J.; Wheeler, V. C.

10.1101/2022.01.27.478096 — genetics — Posted on 2022-01-28

468 Integrating top-down and bottom-up approaches to understand the genetic architecture of speciation across a monkeyflower hybrid zone

Stankowski, S.; Chase, M.; McIntosh, H.; Streisfeld, M. A.

10.1101/2022.01.28.478139 — genetics — Posted on 2022-01-28

469 Single mutation makes Escherichia coli an insect mutualist

Koga, R.; Moriyama, M.; Onodera-Tanifuji, N.; Ishii, Y.; Takai, H.; Mizutani, M.; Oguchi, K.; Okura, R.; Suzuki, S.; Goto, Y.; Hayashi, T.; Seki, M.; Suzuki, Y.; Nishide, Y.; Hosokawa, T.; Wakamoto, Y.; Furusawa, C.; Fukatsu, T.

10.1101/2022.01.26.477692 — evolutionary biology — Posted on 2022-01-28

470 Phenotypic and transcriptomic responses of the sun- and shade-loving plants to sunlight and dim-light conditions

Zhang, Y.; Niu, Y.; Wang, X.; Wang, Z.; Wang, M.; Yang, J.; Wang, Y.; Zhang, W.; Song, Z.; Li, l.

10.1101/2022.01.28.477942 — evolutionary biology — Posted on 2022-01-28

471 Neanderthals did not likely consume Physcomitrium patens - a model moss species

Haas, F. B.; Eisenhofer, R.; Schreiber, M.; Weyrich, L. S.; Rensing, S. A.

10.1101/2022.01.26.472964 — evolutionary biology — Posted on 2022-01-28

472 Recombination, selection and the evolution of tandem gene arrays

Otto, M.; Zheng, Y.; Wiehe, T.

10.1101/2022.01.26.477888 — evolutionary biology — Posted on 2022-01-28

473 Convergent recruitment of Amh as the sex determination gene in two lineages of stickleback fish

Jeffries, D. L.; Peichel, C. L.; Mee, J. A.

10.1101/2022.01.26.477894 — evolutionary biology — Posted on 2022-01-28

474 Sex-specific transcription and DNA methylation landscapes of the Asian citrus psyllid, a vector of huanglongbing pathogens.

Yu, X.; Marshall, H.; Liu, Y.; Xiong, Y.; Zeng, X.; Yu, H.; Chen, W.; Zhou, G.; Zhu, B.; Ross, L.; Lu, Z.

10.1101/2022.01.28.478167 — evolutionary biology — Posted on 2022-01-28

475 Eco-evolutionary feedbacks in the human gut microbiome

Good, B. H.; Rosenfeld, L. B.

10.1101/2022.01.26.477953 — evolutionary biology — Posted on 2022-01-28

476 When host populations move north, but disease moves south: counter-intuitive impacts of climate warming on disease spread

Moran, E. J.; Martignoni, M.; Lecomte, N.; Leighton, P. A.; Hurford, A.

10.1101/2022.01.26.477883 — ecology — Posted on 2022-01-28

477 Modeling Pulse Dynamics of Juvenile Fish Enables the Short-term Forecasting of Population Dynamics in Japanese Pufferfish: A Latent Variable Approach

Nishijima, S.; Suzuki, S.; Fukuta, R.; Okada, M.

10.1101/2022.01.26.477932 — ecology — Posted on 2022-01-28

478 KLF5-regulated extracellular matrix remodeling secures biliary epithelial tissue integrity against cholestatic liver injury

Yamada, M.; Okada, H.; Ema, M.; Kikkawa, Y.; Miyajima, A.; Itoh, T.

10.1101/2022.01.25.477619 — developmental biology — Posted on 2022-01-28

479 Development of DNA methylation-based epigenetic age predictors in loblolly pine (Pinus taeda)

Gardner, S.; Bertucci, E. M.; Sutton, R.; Horcher, A.; Aubrey, D.; Parrott, B.

10.1101/2022.01.27.477887 — developmental biology — Posted on 2022-01-28

480 Sex-Specific Genes Identified in Sea Urchin Gonads are Expressed Prior to Metamorphosis

Pieplow, C.; Wessel, G. M.

10.1101/2022.01.26.477926 — developmental biology — Posted on 2022-01-28

481 Integrated pretraining with evolutionary information to improve RNA secondary structure prediction

Yan, Z.; Hamilton, W. L.; Blanchette, M. D.

10.1101/2022.01.27.478113 — molecular biology — Posted on 2022-01-28

482 Interconversion between Serum Amyloid A native and fibril conformations

Yasar, F.; Sheridan, M. S.; Hansmann, U. H. E.

10.1101/2022.01.27.478066 — molecular biology — Posted on 2022-01-28

483 Micro-colony observation: A rapid and simple approach to count bacterial colony forming units

Bhuyan, S.; Yadav, M.; Giri, S. J.; Sarkar, S.; Begum, S.; Jayswal, A.; Kabyashree, K.; Kumar, A.; Mandal, M.; Ray, S. K.

10.1101/2022.01.26.477842 — microbiology — Posted on 2022-01-28

484 Cross-linked natural IntegroPectin films from Citrus biowaste with intrinsic antimicrobial activity

Piacenza, E.; Presentato, A.; Alduina, R. V.; Scurria, A.; Pagliaro, M.; Albanese, L.; Meneguzzo, F.; Ciriminna, R.; Chillura Martino, D. F.

10.1101/2022.01.28.478153 — microbiology — Posted on 2022-01-28

485 Development of the First Tractable Genetic System for Parvimonas micra, a Ubiquitous Pathobiont in Human Dysbiotic Disease

Higashi, D. L.; McGuire, S.; Abdelrahman, Y.; Zou, Z.; Qin, H.; Anderson, D.; Palmer, E. A.; Kreth, J.; Merritt, J.

10.1101/2022.01.27.477930 — microbiology — Posted on 2022-01-28

486 Fe(III)-dependent anaerobic methane-oxidizing activity in a deep underground borehole demonstrated by in-situ pressure groundwater incubation

Nishimura, H.; Kouduka, M.; Fukuda, A.; Ishimura, T.; Amano, Y.; Beppu, H.; Miyakawa, K.; Suzuki, Y.

10.1101/2022.01.27.478104 — microbiology — Posted on 2022-01-28

487 Transcriptomic and phenomic investigations reveal elements in biofilm repression and formation in the cyanobacterium Synechococcus elongatus PCC 7942

Simkovsky, R.; Parnasa, R.; Wang, J.; Nagar, E.; Zecharia, E.; Suban, S.; Yegorov, Y.; Veltman, B.; Sendersky, E.; Schwarz, R.; Golden, S. S.

10.1101/2022.01.27.477154 — microbiology — Posted on 2022-01-28

488 DNA uptake by cell wall-deficient bacteria reveals a putative ancient macromolecule uptake mechanism

Kapteijn, R.; Shitut, S.; Ashmann, D.; Zhang, L.; de Beer, M.; Daviran, D.; Roverts, R.; Akiva, A.; van Wezel, G.; Kros, A.; Claessen, D.

10.1101/2022.01.27.478057 — microbiology — Posted on 2022-01-28

489 PfD123 modulates K13-mediated survival and recovery after artemisinin exposure.

Noetzel, C.; Kafsack, B. F. C.

10.1101/2022.01.27.476788 — microbiology — Posted on 2022-01-28

490 Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57

Majerciak, V.; Lobanov, A.; Cam, M.; Zheng, Z.-M.

10.1101/2022.01.28.478141 — microbiology — Posted on 2022-01-28

491 Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

Barreira da Silva, R.; Leitao, R.; Pechuan, X.; Werneke, S.; Oeh, J.; Javinal, V.; Wang, Y.; Phung, W.; Everett, C.; Nonomiya, J.; Arnott, D.; Lu, C.; Hsiao, Y.-C.; Koerber, J. T.; Hotzel, I.; Ziai, J.; Modrusan, Z.; Pillow, T.; Roose-Girma, M.; Schartner, J. M.; Merchant, M.; Rutz, S.; Eidenschenk, C.; Mellman, I.; Albert, M.

10.1101/2022.01.25.477769 — immunology — Posted on 2022-01-28

492 T-lymphocyte Tyrosine Hydroxylase Regulates TH 17 T-lymphocytes during Repeated Social Defeat Stress

Elkhatib, S. K.; Moshfegh, C. M.; Watson, G. F.; Case, A. J.

10.1101/2022.01.26.477910 — immunology — Posted on 2022-01-28

493 Macrophages regulate gastrointestinal motility through complement component 1q

Pendse, M.; Li, Y.; Salinas, C. N.; Quinn, G.; Vo, N.; Propheter, D. C.; Dende, C.; Crofts, A. A.; Koo, E.; Hassell, B.; Ruhn, K. A.; Raj, P.; Obata, Y.; Hooper, L. V.

10.1101/2022.01.27.478097 — immunology — Posted on 2022-01-28

494 Decidual innate immune cell kinetics following lipopolysaccharide challenge

St-Germain, L. E.; Castellana, B.; Baltayeva, J.; Beristain, A. G.

10.1101/2022.01.27.478092 — immunology — Posted on 2022-01-28

495 Retinal waves align the concentric orientation map in mouse superior colliculus to the center of vision

Teh, K. L.; Sibille, J.; Kremkow, J.

10.1101/2022.01.26.477810 — neuroscience — Posted on 2022-01-28

496 Evolutionary convergence of a neural mechanism in the cavefish lateral line system

Lunsford, E. T.; Paz, A.; Keene, A. C.; Liao, J. C.

10.1101/2022.01.26.477913 — neuroscience — Posted on 2022-01-28

497 Electrophysiological identification of daily rhythms in the prefrontal cortex

Roberts, B. L.; Wang, J.; Karatsoreos, I. N.

10.1101/2022.01.27.478010 — neuroscience — Posted on 2022-01-28

498 Sensing Echoes: Temporal misalignment as the Earliest Marker of Neurodevelopmental Derail

Torres, E. B.; Bermperidis, T.; Varkey, H.; Vero, J.; London, E.; Phan, H.; Kittler, P.; Gordon, A.; Schafer, S.; Gage, F. H.; Sejnowski, T.

10.1101/2022.01.27.478048 — neuroscience — Posted on 2022-01-28

499 A requirement for correctly scaled synapses in the regulation of motor circuit output

Zubov, T.; do Amaral-Silva, L.; Santin, J. M.

10.1101/2022.01.26.477843 — neuroscience — Posted on 2022-01-28

500 Inflammasome mediated neuronal-microglial crosstalk: a therapeutic substrate in C9orf72-FTD/ALS.

Trageser, K. J.; Smith, C.; Sebastian-Valverde, M.; Iqbal, U. H.; Wu, H.; Estill, M.; Al Rahim, M.; Raval, U.; Herman, F. J.; Zeng, E.; Iban Arias, R.; Oguchi, T.; Zhang, Y.-J.; Petrucelli, L.; Pasinetti, G. M.

10.1101/2022.01.27.478078 — neuroscience — Posted on 2022-01-28

501 Shared and distinct functional effects of patient-specific Tbr1 mutations on cortical development

Co, M.; Barnard, R. A.; Jahncke, J. N.; Grindstaff, S.; Fedorov, L. M.; Adey, A. C.; Wright, K. M.; O'Roak, B. J.

10.1101/2022.01.27.478064 — neuroscience — Posted on 2022-01-28

502 A catalogue of resistance gene homologs and a chromosome-scale reference sequence support resistance gene mapping in winter wheat

Kale, S. M.; Schulthess, A. W.; Padmarasu, S.; Boeven, P.; Schacht, J.; Himmelbach, A.; Steuernagel, B.; Wulff, B.; Reif, J.; Stein, N.; Mascher, M.

10.1101/2022.01.26.477808 — plant biology — Posted on 2022-01-28

503 A peptide-mediated, multilateral molecular dialogue for the coordination of pollen wall formation

Truskina, J.; Bruck, S.; Stintzi, A.; Boeuf, S.; Doll, N. M.; Fujita, S.; Geldner, N.; Schaller, A.; Ingram, G.

10.1101/2022.01.26.477813 — plant biology — Posted on 2022-01-28

504 The T. ispahanicum elongated glume locus P2 maps to chromosome 6A and is associated with the ectopic expression of SVP-A1

Chen, Y.; Liu, Y.; Zhang, J.; Torrance, A.; Watanabe, N.; Adamski, N. M.; Uauy, C.

10.1101/2022.01.27.478079 — plant biology — Posted on 2022-01-28

505 FRIENDLY (FMT) is an RNA binding protein associated with cytosolic ribosomes at the mitochondrial surface

Hemono, M.; Salinas-Giege, T.; Roignant, J.; Vingadassalon, A.; Hammann, P.; Ubrig, E.; Ngondo, P.; Duchene, A.-M.

10.1101/2022.01.27.478018 — plant biology — Posted on 2022-01-28

506 STK25 inhibits PKA signaling by phosphorylating PRKAR1A

Zhang, X.; Wang, B. Z.; Kim, M.; Nash, T.; Liu, B.; Rao, J.; Lock, R.; Tamargo, M.; Soni, R.; Belov, J.; Li, E.; Vunjak-Novakovic, G.; Fine, B.

10.1101/2022.01.27.478084 — physiology — Posted on 2022-01-28

507 Three-dimensional actuation of hummingbird wings requires diverse effects from the primary flight muscles

Agrawal, S.; Tobalske, B. W.; Anwar, M. Z.; Luo, H.; Hedrick, T. L.; Cheng, B.

10.1101/2022.01.27.477984 — biophysics — Posted on 2022-01-28

508 Assessment of AlphaFold2 residue conformations for human proteins

Baek, K. T.; Kepp, K. P.

10.1101/2022.01.28.478137 — biophysics — Posted on 2022-01-28

509 Parameterization and Application of the General Amber Force Field to Model Fluro Substituted Furanose Moieties and Nucleosides

Escalante, D. E.; Aldrich, C. C.; Ferguson, D. M.

10.1101/2022.01.26.477958 — biophysics — Posted on 2022-01-28

510 Dynamics of Human Serum Transferrin in Varying Physicochemical Conditions Explored by Using Molecular Dynamics Simulations

Indrakumar, S.; Kulakova, A.; Harris, P.; Peters, G.

10.1101/2022.01.28.478130 — biophysics — Posted on 2022-01-28

511 NGSEP 4: Efficient and Accurate Identification of Orthogroups and Whole Genome Alignment

Tello, D.; Gonzalez-Garcia, L. N.; Gomez, J.; Zuluaga-Monares, J. C.; Garcia, R.; Angel, R.; Mahecha, D.; Duarte, E.; Leon, M. d. R.; Reyes, F.; Escobar-Velasquez, C.; Linares-Vasquez, M.; Cardozo, N.; Duitama, J.

10.1101/2022.01.27.478091 — bioinformatics — Posted on 2022-01-28

512 ARZIMM: A Novel Analytic Platform for the Inference of Microbial Interactions and Community Stability from Longitudinal Microbiome Study

Li, H.; He, L.; wang, c.; Hu, J.; Gao, z.; Falcone, E.; Holland, S.; Blaser, M.

10.1101/2022.01.26.477892 — bioinformatics — Posted on 2022-01-28

513 Innate immune cell response to host-parasite interaction in a human intestinal tissue microphysiological system

Humayun, M.; Ayuso, J. M.; Park, K. Y.; Di Genova, B. M.; Skala, M.; Kerr, S. C.; Knoll, L.; Beebe, D.

10.1101/2022.01.27.478058 — bioengineering — Posted on 2022-01-28

514 In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesis

McDonald, A. G.; Mariethoz, J.; Davey, G. P.; Lisacek, F.

10.1101/2022.01.27.477885 — biochemistry — Posted on 2022-01-28

515 Microdynamics of lamin A Ig-fold domain regulates higher order assembly of the protein

Mukherjee, C.; Sengupta, D.; Maganti, L.; Mahendar, M.; Bhattacharyya, D.; SENGUPTA, K.

10.1101/2022.01.27.478013 — biochemistry — Posted on 2022-01-28

516 Role of RIGI, MDA5 and interferon alpha of duck in Duck Plague infection, a novel report

Pal, S.; Banerjee, S.; Pal, A.; Kalita, D. j.; Batabyal, S.; Debnath, M.; Chakraborty, A.; Mondal, G.; Roy, B.; Chatterjee, P.; Pal, A.

10.1101/2022.01.26.477779 — genomics — Posted on 2022-01-28

517 Divergent Golgi Trafficking Limits B cell-Mediated IgG Sialylation

Glendenning, L. M.; Zhou, J. Y.; Reynero, K. M.; Cobb, B. A.

10.1101/2022.01.25.477787 — immunology — Posted on 2022-01-28

518 Macrophage-derived VEGF-C decreases hematogenous metastatic dissemination by normalizing the tumor vasculature

Ferreira, S. d. S.; Wallmann, T.; Kerzel, T.; Wallerius, M.; Bartish, M.; Landwehr, L. S.; Pan, Y.; Agardy, D. A.; Hartman, J.; Squadrito, M. L.; Rolny, C.

10.1101/2022.01.26.468593 — cancer biology — Posted on 2022-01-28

519 Deep Learning Characterization of Brain Tumours With Diffusion Weighted Imaging

Meaney, C.; Das, S.; Colak, E.; Kohandel, M.

10.1101/2022.01.25.477747 — cancer biology — Posted on 2022-01-28

520 The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progression

Gupta, N.; Song, H.; Wu, W.; Ponce, R.; Lin, Y.; Kim, J. W.; Small, E.; Feng, F.; Huang, F. W.; Okimoto, R.

10.1101/2022.01.26.477820 — cancer biology — Posted on 2022-01-28

521 The ALT pathway generates telomere fusions that can be detected in the blood of cancer patients

Muyas, F.; Gomez Rodriguez, M. J.; Cortes-Ciriano, I.; Flores, I.

10.1101/2022.01.25.477771 — cancer biology — Posted on 2022-01-28

522 Inhibitor of the nuclear transport protein XPO1 enhances the anticancer efficacy of KRAS G12C inhibitors in preclinical models of KRAS G12C mutant cancers

Khan, H. Y.; Nagasaka, M.; Li, Y.; Aboukameel, A.; Uddin, M. H.; Sexton, R.; Bannoura, S.; Mzannar, Y.; Al-Hallak, M. N.; Kim, S.; Beydoun, R.; Landesman, Y.; Mamdani, H.; Uprety, D.; Philip, P. A.; Mohammad, R.; Shields, A.; Azmi, A. S.

10.1101/2022.01.26.477874 — cancer biology — Posted on 2022-01-28

523 An exactly valid and distribution-free statistical significance test for correlations between time series

Yuan, A. E.; Shou, W.

10.1101/2022.01.25.477698 — bioinformatics — Posted on 2022-01-28

524 The N764K and N856K mutations in SARS-CoV-2 Omicron BA.1 S protein generate potential cleavage sites for SKI-1/S1P protease

Maaroufi, H.

10.1101/2022.01.21.477298 — bioinformatics — Posted on 2022-01-28

525 A universal insect trait tool (ITT, v1.0) for statistical analysis and evaluation of biodiversity research data

Hoerren, T.; Sorg, M.; Hallmann, C. A.; Zizka, V. M. A.; Ssymank, A.; Noll, N. W.; Schaeffler, L.; Scherber, C.

10.1101/2022.01.25.477751 — ecology — Posted on 2022-01-28

526 LCK-14-3-3ζ-TRPM8 axis for regulating TRPM8 function/assembly promotes pancreatic cancer malignancy

Tang, J.; Zhou, C.; Chen, X.-Z.; Zhang, R.

10.1101/2022.01.26.477835 — cell biology — Posted on 2022-01-28

527 Single-cell RNA sequencing identifies phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow

Li, H.; Braunig, S.; Lang, S.; Scheding, S.

10.1101/2022.01.26.477664 — cell biology — Posted on 2022-01-28

528 Emodin Combined with Multiple Low-frequency Low-intensity Ultrasound to Relieve Osteomyelitis Through Sonoantimicrobial Chemotherapy

Lu, F.; Wu, X.; Hu, H.; He, Z.; Sun, J.; Zhang, J.; Song, X.; Jin, X.; Chen, G.

10.1101/2022.01.26.477965 — microbiology — Posted on 2022-01-28

529 Zapline-plus: a Zapline extension for automatic and adaptive removal of frequency-specific noise artifacts in M/EEG

Klug, M.; Kloosterman, N. A.

10.1101/2021.10.18.464805 — neuroscience — Posted on 2022-01-28

530 High performance liquid chromatography-based metabolomics of Psidium guajava Linn. leaf extracts

Gholkar, M. S.; Daswani, P. G.; Iyer, V. V.; Birdi, T. J.

10.1101/2022.01.25.477015 — systems biology — Posted on 2022-01-28

531 Shade-induced transcription of PIF-Direct-Target Genes precedes H3K4-trimethylation chromatin modifications

Calderon, R. H.; Dalton-Roesler, J.; Zhang, Y.; Quail, P. H.

10.1101/2022.01.27.478074 — plant biology — Posted on 2022-01-28

532 A high-throughput approach to identify reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae

Kumar, R.; Oke, A.; Rockmill, B.; de Cruz, M.; Verduzco, R.; Madeira, X. W.; Abrahamsson, D.; Robinson, J.; Allard, P.; Woodruff, T.; Fung, J.

10.1101/2022.01.25.477777 — pharmacology and toxicology — Posted on 2022-01-28

533 Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

Hu, S.; Wang, N.; Chen, S.; Ding, Q.; Wang, C.; Ma, W.; Zhang, X.; Wu, Y.; Lv, Y.; Xue, Z.; Bai, H.; Ge, S.; He, H.; Lu, W.; Zhang, T.; Ding, Y.; Liu, R.; Han, S.; Zhan, Y.; Zhan, G.; Guo, Z.; Zhang, Y.; Lu, J.; Gao, J.; Jia, Q.; Wang, Y.; Wang, H.; Lu, S.; Zhang, H.; He, L.

10.1101/2022.01.22.477323 — pharmacology and toxicology — Posted on 2022-01-28

534 Distinct and common features of numerical and structural chromosomal instability across different cancer types

Zhang, X.; Kschischo, M.

10.1101/2021.10.15.464567 — cancer biology — Posted on 2022-01-28

535 Spectral clustering of single-cell multi-omics data on multilayer graphs

Zhang, S.; Leistico, J. R.; Cho, R. J.; Cheng, J. B.; Song, J. S.

10.1101/2022.01.24.477443 — bioinformatics — Posted on 2022-01-28

536 Involvement of non-LTR retrotransposons in the cancer incidence and lifespan of mammals

Ricci, M.; Peona, V.; Taccioli, C.

10.1101/2021.09.27.461867 — evolutionary biology — Posted on 2022-01-28

537 DEVELOPMENTAL AND EVOLUTIONARY COMPARATIVE ANALYSIS OF A HOXD REGULATORY LANDSCAPE IN MAMMALS AND BIRDS

Hintermann, A.; Guerreiro, I.; Bolt, C. C.; Gitto, S.; Duboule, D.; Beccari, L.

10.1101/2021.08.12.456039 — developmental biology — Posted on 2022-01-28

538 Panoramic visual statistics shape retina-wide organization of receptive fields

Gupta, D.; Mlynarski, W.; Symonova, O.; Svaton, J.; Joesch, M.

10.1101/2022.01.11.475815 — neuroscience — Posted on 2022-01-28

539 Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity

Izgi, H.; Han, D.; Isildak, U.; Huang, S.; Kocabiyik, E.; Khaitovich, P.; Somel, M.; Dönertas, H. M.

10.1101/2021.03.02.432281 — genomics — Posted on 2022-01-28

540 Common Dynamic Determinants Govern Quorum Quenching Activity in N-terminal Serine Hydrolases

Surpeta, B.; Grulich, M.; Palyzova, A.; Maresova, H.; Brezovsky, J.

10.1101/2022.01.13.476167 — biochemistry — Posted on 2022-01-28

541 Puromycin is incorporated into regenerating flagella of Chlamydomonas reinhardtii as an indicator of nascent flagellar proteins

Kubo, T.; Kanou, N.; Oda, T.

10.1101/2022.01.27.478094 — cell biology — Posted on 2022-01-28

542 A studyforrest extension, MEG recordings while watching the audio-visual movie "Forrest Gump"

Liu, X.; Dai, Y.; Xie, H.; Zhen, Z.

10.1101/2021.06.04.446837 — neuroscience — Posted on 2022-01-28

543 Random Compressed Coding with Neurons

Blanco Malerba, S.; Pieropan, M.; Burak, Y.; Azeredo da Silveira, R.

10.1101/2022.01.06.475186 — neuroscience — Posted on 2022-01-28

544 A silent disco: Persistent entrainment of low-frequency neural oscillations underlies beat-based, but not pattern-based temporal expectations

Bouwer, F. L.; Fahrenfort, J. J.; Millard, S. K.; Kloosterman, N. A.; Slagter, H. A.

10.1101/2020.01.08.899278 — neuroscience — Posted on 2022-01-28

545 Semaphorin 3C exacerbates liver fibrosis

De Angelis Rigotti, F.; Wiedmann, L.; Hubert, M. O.; Vacca, M.; Hasan, S. S.; Moll, I.; Carvajal, S.; Jimenez, W.; Starostecka, M.; Billeter, A. T.; Müller-Stich, B.; Wolff, G.; Ekim-Üstünel, B.; Herzig, S.; Mogler, C.; Fischer, A.; Rodriguez-Vita, J.

10.1101/2021.07.29.454292 — pathology — Posted on 2022-01-28

546 Brain-keratinocyte communication suffices for epidermal daily homeostasis

Mortimer, T.; Zinna, V. M.; Laudanna, C.; Petrus, P.; Koronowski, K. B.; Smith, J. G.; Greco, C. M.; Garcia-Lara, E.; Kumar, A.; Vaca-Dempere, M.; Deryagin, O.; Forrow, S.; Welz, P.-S.; Munoz Canoves, P.; Aznar Benitah, S.

10.1101/2022.01.26.477844 — cell biology — Posted on 2022-01-28

547 A pipeline to track unlabeled cells in wide migration chambers using pseudofluorescence

Antonello, P.; Thelen, M.; Krause, R.; Pizzagalli, D. U.

10.1101/2022.01.26.476896 — cell biology — Posted on 2022-01-28

548 Robust, versatile DNA FISH probes for chromosome-specific repeats in Caenorhabditis elegans and Pristionchus pacificus

Adilardi, R. S.; Dernburg, A. F.

10.1101/2022.01.25.477430 — cell biology — Posted on 2022-01-28

549 Local PI(4,5)P2 generation controls fusion pore expansion during exocytosis

Omar-Hmeadi, M.; Gucek, A.; Barg, S.

10.1101/2022.01.26.477824 — cell biology — Posted on 2022-01-28

550 Upregulation of Trem2 expression occurs exclusively on microglial contact with plaques

Wood, J.; Wong, E.; Joghee, R.; Balbaa, A.; Vitanova, K. S.; Vanshoiack, A.; Phelan, S.-L. J.; Launchbury, F.; Desai, S.; Tripathi, T.; Hanrieder, J.; Cummings, D. M.; Hardy, J.; Edwards, F. A.

10.1101/2022.01.26.477873 — neuroscience — Posted on 2022-01-28

551 A Complete Set of Equations and Parameters for the Computational Model of Mitochondrial Function for the Proximal Convoluted Tubule and Medullary Thick Ascending Limb Cells in the Rat Kidney

Bell, W.; Layton, A.

10.1101/2022.01.27.477845 — cell biology — Posted on 2022-01-28

552 Transcription factor determines the sources of extracellular vesicle DNA

Zhang, Y.; Ding, N.; Li, Y.; Zhao, X.; Yang, S.; Fu, P.; Peng, Y.; Cheng, H.; Ouyang, M.; Wang, Y.; Liu, H.; Chen, Y.; Huang, X.; Yu, L.; Tan, Y.

10.1101/2022.01.27.477315 — cell biology — Posted on 2022-01-28

553 Robust and reproducible neuronal differentiation of human embryonic stem cells for neurotoxicology

Samara, A.; Falck, M.; Spildrejorde, M.; Leithaug, M.; Acharya, G.; Lyle, R.; Eskeland, R.

10.1101/2022.01.26.477818 — cell biology — Posted on 2022-01-28

554 AICAR-mediated selection of karyotypically normal cells in Pallister Killian syndrome patient-derived skin fibroblasts

Salzano, E.; Kaur, M.; Jacko, A. M.; Mceldrew, D. A.; Raible, S. E.; Krantz, I.; Izumi, K.

10.1101/2022.01.27.478025 — cell biology — Posted on 2022-01-27

555 Multi-modal and multi-subject modular organization of human brain networks

Puxeddu, M. G.; Faskowitz, J.; Sporns, O.; Astolfi, L.; Betzel, R. F.

10.1101/2022.01.26.477897 — neuroscience — Posted on 2022-01-27

556 Dense poly(ethylene glycol) coatings maximize nanoparticle transport across lymphatic endothelial cells and accumulate in the skin draining lymph nodes

McCright, J. C.; Skeen, C.; Yarmovsky, J.; Maisel, K.

10.1101/2020.08.01.232249 — bioengineering — Posted on 2022-01-27

557 Tracking human skill learning with a hierarchical Bayesian sequence model

Elteto, N.; Nemeth, D.; Janacsek, K.; Dayan, P.

10.1101/2022.01.27.477977 — animal behavior and cognition — Posted on 2022-01-27

558 The Blepharisma stoltei macronuclear genome: towards the origins of whole genome reorganization

Singh, M.; Seah, B. K. B.; Emmerich, C.; Singh, A.; Woehle, C.; Huettel, B.; Byerly, A.; Stover, N. A.; Sugiura, M.; Harumoto, T.; Swart, E. C.

10.1101/2021.12.14.471607 — genomics — Posted on 2022-01-27

559 Unified classification of mouse retinal ganglion cells using function, morphology, and gene expression

Goetz, J.; Jessen, Z. F.; Jacobi, A.; Mani, A.; Cooler, S.; Greer, D.; Kadri, S.; Segal, J.; Shekhar, K.; Sanes, J.; Schwartz, G.

10.1101/2021.06.10.447922 — neuroscience — Posted on 2022-01-27

560 TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

Jairaman, A.; McQuade, A.; Granzotto, A.; Kang, Y. J.; Chadarevian, J. P.; Gandhi, S.; Parker, I.; Smith, I.; Cho, H.; Sensi, S. L.; Othy, S.; Blurton-Jones, M.; Cahalan, M. D.

10.1101/2021.08.24.457491 — neuroscience — Posted on 2022-01-27

561 Temporal filters in response to presynaptic spike trains: Interplay of cellular, synaptic and short-term plasticity time scales

Mondal, Y.; Pena, R. F. O.; Rotstein, H. G.

10.1101/2021.09.16.460719 — neuroscience — Posted on 2022-01-27

562 An enhanced inverted encoding model for neural reconstructions

Scotti, P. S.; Chen, J.; Golomb, J. D.

10.1101/2021.05.22.445245 — neuroscience — Posted on 2022-01-27

563 High School Science Fair: Ethnicity Trends in Student Participation and Experience

Grinnell, F.; Dalley, S.; Reisch, J.

10.1101/2021.12.03.471190 — scientific communication and education — Posted on 2022-01-27

564 Multi-omics analysis combining pyroptosis-related signatures for building a prognosis prediction model in hepatocellular carcinoma

Huang, J.; Li, Y.; Chu, M.; Wang, Y.

10.1101/2022.01.24.477487 — cancer biology — Posted on 2022-01-27

565 Learning latent embedding of multi-modal single cell data and cross-modality relationship simultaneously

Zhang, Z.; Yang, C.; Zhang, X.

10.1101/2021.04.16.440230 — bioinformatics — Posted on 2022-01-27

566 Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies

Zhang, J.; Dutta, D.; Köttgen, A.; Tin, A.; Schlosser, P.; Grams, M. E.; Harvey, B.; CKDGen Consortium, ; Yu, B.; Boerwinkle, E.; Coresh, J.; Chatterjee, N.

10.1101/2021.03.15.435533 — genetics — Posted on 2022-01-27

567 Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche

Patel, A.; Wu, Y.; Han, X.; Su, Y.; Maugel, T. K.; Shroff, H.; Roy, S.

10.1101/2021.10.29.466429 — developmental biology — Posted on 2022-01-27

568 Endoglin deficiency elicits hypoxia-driven congestive heart failure in zebrafish.

Lelievre, E.; Bureau, C.; Bordat, Y.; Fretaud, M.; Langevin, C.; Jopling, C.; Kissa, K.

10.1101/2021.10.09.463775 — developmental biology — Posted on 2022-01-27

569 The plant-specific DDR factor SOG1 increases chromatin mobility in response to DNA damage

Meschichi, A.; Reeck, S.; Sicard, A.; Pontvianne, F.; Rosa, S.

10.1101/2021.11.03.466744 — cell biology — Posted on 2022-01-27

570 Dietary fat promotes antibiotic-induced Clostridioides difficile mortality in mice

Hazleton, K. Z.; Martin, C. G.; Orlicky, D. J.; Arnolds, K. L.; Nusbacher, N. M.; Moreno-Huizar, N.; Armstrong, M. L.; Reisdorph, N.; Lozupone, C. A.

10.1101/828939 — microbiology — Posted on 2022-01-27

571 Anaerobic conditions unmask antimicrobial resistance in Vibrio cholerae

Creasy-Marrazzo, A.; Saber, M. M.; Kamat, M.; Bailey, L. S.; Brinkley, L. M.; Begum, Y. A.; Rashid, M. M.; Khan, A. I.; Qadri, F.; Basso, K. B.; Shapiro, B. J.; Nelson, E. J.

10.1101/2021.06.26.450051 — microbiology — Posted on 2022-01-27

572 Erythropoietin directly remodels the clonal composition of murine hematopoietic multipotent progenitor cells

Eisele, A. S.; Cosgrove, J.; Magniez, A.; Tubeuf, E.; Tenreira Bento, S.; Conrad, C.; Cayrac, F.; Tak, T.; Lyne, A.-M.; Urbanus, J.; Perie, L.

10.1101/2020.04.20.050146 — immunology — Posted on 2022-01-27

573 Rethinking Statistical Learning as a Dynamic Stochastic Process, from The Motor Systems Perspective

Vaskevich, A.; Torres, E. B.

10.1101/2022.01.18.476831 — neuroscience — Posted on 2022-01-27

574 Human cortical areas are sparsely connected: Combining histology with diffusion MRI to estimate the absolute number of axons

Rosen, B. Q.; Halgren, E.

10.1101/2021.06.07.447453 — neuroscience — Posted on 2022-01-27

575 A neural network account of memory replay and knowledge consolidation

Barry, D. N.; Love, B. C.

10.1101/2021.05.25.445587 — neuroscience — Posted on 2022-01-27

576 Microglia Stimulate Zebrafish Brain Repair Via a Specific Inflammatory Cascade

Kanagaraj, P.; Chen, J. Y.; Skaggs, K.; Qadeer, Y.; Conner, M.; Cutler, N.; Richmond, J.; Kommidi, V.; Poles, A.; Affrunti, D.; Powell, C.; Goldman, D.; Parent, J. M.

10.1101/2020.10.08.330662 — neuroscience — Posted on 2022-01-27

577 Beyond rates: Time-varying dynamics of high frequency oscillations as a biomarker of the seizure onset zone

Nunez, M. D.; Charupanit, K.; Sen-Gupta, I.; Lopour, B. A.; Lin, J. J.

10.1101/2020.05.28.122416 — neuroscience — Posted on 2022-01-27

578 A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors

Rothweiler, E.; Stefaniak, J.; Ward, J.; Rogers, C.; Balikci, E.; Huber, K. V. M.

10.1101/2022.01.20.477145 — systems biology — Posted on 2022-01-27

579 GCN5L1 promotes diastolic dysfunction by inhibiting cardiac pyruvate oxidation

Thapa, D.; Bugga, P.; Mushala, B. A. S.; Manning, J. R.; Stoner, M. W.; McMahon, B.; Zeng, X.; Cantrell, P.; Yates, N.; Xie, B.; Edmunds, L. R.; Jurczak, M. J.; Scott, I.

10.1101/2021.09.07.459319 — physiology — Posted on 2022-01-27

580 Hijacking Methyl Reader proteins for Nuclear-Specific Protein Degradation

Nalawansha, D. A.; Li, K.; Hines, J.; Crews, C. M.

10.1101/2022.01.24.477424 — pharmacology and toxicology — Posted on 2022-01-27

581 Co-linear chaining with overlaps and gap costs

Jain, C.; Gibney, D.; Thankachan, S. V.

10.1101/2021.02.03.429492 — bioinformatics — Posted on 2022-01-27

582 Simulated docking reveals putative channels for the transport of long-chain fatty acids in Vibrio cholerae

Turgeson, A. W.; Giles, D. K.; Harris, B. J.

10.1101/2022.01.26.477967 — molecular biology — Posted on 2022-01-27

583 Functional and evolutionary significance of unknown genes from uncultivated taxa

Rodriguez del Rio, A.; Giner-Lamia, J.; Cantalapiedra, C. P.; Botas, J.; Deng, Z.; Hernandez-Plaza, A.; Paoli, L.; Schmidt, T. S.; Sunagawa, S.; Bork, P.; Coelho, L. P.; Huerta-Cepas, J.

10.1101/2022.01.26.477801 — microbiology — Posted on 2022-01-27

584 B-cell epitope mapping of TprC and TprD variants of Treponema pallidum subspecies

Molini, B. J.; Fernandez, M.; Godornes, C.; Vorobieva, A.; Lukehart, S.; Giacani, L.

10.1101/2022.01.26.477776 — microbiology — Posted on 2022-01-27

585 Biocompatible fluorocarbon liquid underlays for in situ extraction of isoprenoids from microbial cultures

Overmans, S.; Lauersen, K. J.

10.1101/2022.01.27.477974 — synthetic biology — Posted on 2022-01-27

586 Grandmaternal allergen exposure causes distinct epigenetic trajectories in offspring associated with airway hyperreactivity and inflammation.

Lebold, K. M.; Cook, M.; Pincus, A. B.; Nevonen, K. A.; Davis, B. A.; Carbone, L.; Calco, G. N.; Fryer, A. D.; Jacoby, D. B.; Drake, M. G.

10.1101/2022.01.25.477760 — physiology — Posted on 2022-01-27

587 Marine Bacteria Chemotaxis to Crude Oil Components with Opposing Effects

Zhao, X.; Ford, R. M.

10.1101/2022.01.26.477900 — bioengineering — Posted on 2022-01-27

588 Permethylation of ribonucleosides provides enhanced mass spectrometry quantification of post-transcriptional modifications

Xie, Y.; Janssen, K. A.; Scacchetti, A.; Bonasio, R.; Garcia, B. A.

10.1101/2022.01.26.477959 — biochemistry — Posted on 2022-01-27

589 Pyrrole produced by Pseudomonas aeruginosa influences olfactory food choice of Caenorhabditis elegans

Prakash, D.; Siddiqui, R.; Chalasani, S. H.; Singh, V.

10.1101/2022.01.27.477966 — animal behavior and cognition — Posted on 2022-01-27

590 Programmable eukaryotic protein expression with RNA sensors

Jiang, K.; Koob, J.; Chen, X. D.; Krajeski, R. N.; Zhang, Y.; Villiger, L.; Zhou, W.; Abudayyeh, O. O.; Chen, F.; Gootenberg, J. S.

10.1101/2022.01.26.477951 — genomics — Posted on 2022-01-27

591 Genetic Regulation of Circular RNA Expression in Human Aortic Smooth Muscle Cells and Vascular Traits

Aherrahrou, R.; Lue, D.; Civelek, M.

10.1101/2022.01.26.477946 — genetics — Posted on 2022-01-27

592 An organoid CRISPRi screen revealed that SOX9 primes human fetal lung tip progenitors to receive WNT and RTK signals

Sun, D.; Batlle, O. L.; van den Ameele, J.; Thomas, J. C.; He, P.; Lim, K.; Tang, W.; Xu, C.; Meyer, K. B.; Teichmann, S. A.; Marioni, J.; Jackson, S. P.; Brand, A. H.; Rawlins, E. L.

10.1101/2022.01.27.478034 — developmental biology — Posted on 2022-01-27

593 Single-cell RNA sequencing identifies phenotypically, functionally, and anatomically distinct stromal niche populations in human bone marrow

Li, H.; Braunig, S.; Lang, S.; Scheding, S.

10.1101/2022.01.26.477664 — cell biology — Posted on 2022-01-27

594 cir-DNA sequencing revealed the landscape of extrachromosomal circular DNA in articular cartilage and the potential roles in osteoarthritis

Ni, Z.; Kuang, L.; Gao, C.; Xiang, W.; Zhang, T.; Li, S.; Gong, Y.; Luo, X.; Yuan, J.; Wu, Y.; Yan, X.; Xiong, Y.; Liang, J.; Zhao, G.

10.1101/2022.01.27.477985 — molecular biology — Posted on 2022-01-27

595 An Optimal Regulation of Fluxes Dictates Microbial Growth In and Out of Steady-State

Chure, G.; Cremer, J.

10.1101/2022.01.27.477569 — microbiology — Posted on 2022-01-27

596 Ultramicrobacteria in various fermented cabbages

Lee, H.-W.; Yoon, S.-R.; Dang, Y.-M.; Kang, M.; Lee, K. H.; Ha, J.-H.; Bae, J.-W.

10.1101/2022.01.26.477936 — microbiology — Posted on 2022-01-27

597 A novel bacteriocin produced by Bifidobacterium longum subsp. infantis has dual antimicrobial and immunomodulatory activity

Javvadi, S. G.; Kujawska, M.; Papp, D.; Gontarczyk, A. M.; Jordan, A.; Lawson, M. A.; O'Neill, I. J.; Alcon-Giner, C.; Clarke, P.; Beraza, N.; Hall, L. J.

10.1101/2022.01.27.477972 — microbiology — Posted on 2022-01-27

598 Molecular mechanisms of Plasmodium development in male and female Anopheles mosquitoes

Haraguchi, A.; Takano, M.; Hakozaki, J.; Nakayama, K.; Nakamura, S.; Yoshikawa, Y.; Fukumoto, S.; Kusakisako, K.; Ikadai, H.

10.1101/2022.01.27.477980 — microbiology — Posted on 2022-01-27

599 KaiC-like proteins improve stress resistance in environmental Pseudomonas species

Terrettaz, C.; Cabete, B.; Geiser, J.; Valentini, M.; Gonzalez, D.

10.1101/2022.01.26.477890 — microbiology — Posted on 2022-01-27

600 Direct type I Interferon signaling in hepatocytes control malaria

Marques-da-Silva, C.; Peissig, K.; Walker, M. P.; Shiau, J.; Kyle, D. E.; Vijay, R.; Lindner, S. E.; Kurup, S. P.

10.1101/2022.01.26.477934 — immunology — Posted on 2022-01-27

601 Germinal center-derived broadly neutralizing antibodies adapt to SARS-CoV-2 antigenic drift

Shitaoka, K.; Kawano, Y.; Higashiura, A.; Mizoguchi, Y.; Hashiguchi, T.; Nishimichi, N.; Huang, S.; Ito, A.; Yamamoto, A.; Ohki, S.; Kanda, M.; Taniguchi, T.; Yokosaki, Y.; Okada, S.; Sakaguchi, T.; Yasuda, T.

10.1101/2022.01.26.477937 — immunology — Posted on 2022-01-27

602 The antimicrobial peptide cathelicidin is critical for the development of Th17 responses in severe inflammatory disease

Smith, K. J.; Minns, D.; McHugh, B.; Holloway, R.; O'Connor, R.; Williams, A.; Melrose, L.; McPherson, R.; Miron, V. E.; Davidson, D. J.; Gwyer Findlay, E.

10.1101/2022.01.27.477976 — immunology — Posted on 2022-01-27

603 The IMD and JNK pathways drive the functional integration of the immune and circulatory systems of mosquitoes

Yan, Y.; Sigle, L. T.; Rinker, D. C.; Estevez-Lao, T. Y.; Capra, J. A.; Hillyer, J. F.

10.1101/2022.01.26.477938 — immunology — Posted on 2022-01-27

604 Molecular insights into the MCM8/9 helicase complex in DNA unwinding and translocation

Weng, Z.; Li, J.; Zheng, J.; Li, H.; Lu, Z.; Zhou, Y.; Xu, D.; Liang, H.; Liu, Y.

10.1101/2022.01.26.477944 — biophysics — Posted on 2022-01-27

605 Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers

Wu, S.; Sirkis, D. W.; Schekman, R.

10.1101/2022.01.27.477991 — biochemistry — Posted on 2022-01-27

606 Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes

Ito, Y.; Chadani, Y.; Niwa, T.; Yamakawa, A.; Machida, K.; Imataka, H.; Taguchi, H.

10.1101/2022.01.27.477990 — biochemistry — Posted on 2022-01-27

607 Multivalent interactions essential for lentiviral integrase function

Ballandras-Colas, A.; Chivukula, V.; Gruszka, D. T.; Shan, Z.; Singh, P. K.; Pye, V. E.; McLean, R. K.; Bedwell, G. J.; Li, W.; Nans, A.; Cook, N. J.; Fadel, H. J.; Poeschla, E. M.; Griffiths, D. J.; Vargas, J.; Taylor, I. A.; Lyumkis, D.; Yardimci, H.; Engelman, A. N.; Cherepanov, P.

10.1101/2022.01.26.477893 — biochemistry — Posted on 2022-01-27

608 Serum proteomics identifies immune pathways and candidate biomarkers of coronavirus infection in wild vampire bats

Becker, D.; Lei, G.-S.; Janech, M. G.; Brand, A. M.; Fenton, B.; Simmons, N. B.; Neely, B. A.

10.1101/2022.01.26.477790 — ecology — Posted on 2022-01-27

609 Ultraviolet Dosage and Decontamination Efficacy was Widely Variable Across 14 UV Devices after Testing a Dried Enveloped Ribonucleic Acid Virus Surrogate for SARS-CoV-2

Buhr, T. L.; Borgers-Klonkowski, E.; Gutting, B. W.; Hammer, E. E.; Hamilton, S. M.; Huhman, B. M.; Jackson, S. L.; Kennihan, N. L.; Lilly, S. D.; Little, J. D.; Luck, B. B.; Matuczinski, E. A.; Miller, C. T.; Sides, R. E.; Yates, V. L.; Young, A. A.

10.1101/2022.01.27.478063 — microbiology — Posted on 2022-01-27

610 The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition

Sacco, M. D.; Hu, Y.; Gongora, M. V.; Meilleur, F.; Kemp, M. T.; Zhang, X.; Wang, J.; Chen, Y.

10.1101/2022.01.26.477774 — microbiology — Posted on 2022-01-27

611 Effect of SARS-CoV-2 spike mutations on its activation by TMPRSS2 and TMPRSS13

Stevaert, A.; Van Berwaer, R.; Raeymaekers, V.; Laporte, M.; Naesens, L. M. J.

10.1101/2022.01.26.477969 — microbiology — Posted on 2022-01-27

612 Evaluation of heat inactivation of human norovirus in freshwater clams using human intestinal enteroids

Hayashi, T.; Yamaoka, Y.; Ito, A.; Kamaishi, T.; Estes, M. K.; Muramatsu, M.; Murakami, K.

10.1101/2022.01.27.477812 — microbiology — Posted on 2022-01-27

613 JQ-1 ameliorates schistosomiasis liver granuloma in mice by suppressing male and female reproductive systems and egg development of Schistosoma japonicum

Tian, J.; Dai, B.; Gong, L.; Wang, P.; Ding, H.; Xia, S.; Sun, W.; Ren, C.; Shen, J.; Liu, M.

10.1101/2022.01.27.477981 — microbiology — Posted on 2022-01-27

614 Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19

Peddireddy, S. P.; Rahman, S. A.; Cillo, A. R.; Vijay, G. M.; Somasundaram, A.; Workman, C. J.; Bain, W.; McVerry, B. J.; Methe, B.; Lee, J. S.; Ray, P.; Ray, A.; Bruno, T. C.; Vignali, D. A.; Kitsios, G. D.; Morris, A.; Singh, H.; Sarkar, A.; Das, J.

10.1101/2022.01.24.477545 — immunology — Posted on 2022-01-27

615 Defining the Substrate Envelope of SARS-CoV-2 Main Protease to Predict and Avoid Drug Resistance

Shaqra, A. M.; Zvornicanin, S.; Huang, Q. Y.; Lockbaum, G. J.; Knapp, M.; Tandeske, L.; Barkan, D. T.; Flynn, J.; Bolon, D. N.; Moquin, S.; Dovala, D.; Kurt Yilmaz, N.; Schiffer, C. A.

10.1101/2022.01.25.477757 — biochemistry — Posted on 2022-01-27

616 Impact of various vaccine boosters on neutralization against Omicron following prime vaccinations with inactivated or adenovirus-vectored vaccine

Huang, Q.; Zeng, J.; Lang, Q.; Gao, F.; Liu, D.; Tian, S.; Shi, R.; Luo, L.; Wang, H.; Hu, L.; Jiang, L.; Liu, Y.; Li, K.; Wu, Y.; Xu, J.; Jiang, W.; Guo, N.; Chen, Z.; Hao, X.; Jin, R.; Yan, J.; Sun, Y.

10.1101/2022.01.25.476850 — immunology — Posted on 2022-01-27

617 On the flexibility of the cellular amination network in E. coli

Lindner, S. N.; Schulz-Mirbach, H.; Müller, A.; Wu, T.; Pfister, P.; Aslan, S.; Schada von Borzyskowski, L.; Erb, T.; Bar-Even, A.

10.1101/2022.01.25.477661 — systems biology — Posted on 2022-01-27

618 Machine Learning for the Identification of Viral Attachment Machinery from Respiratory Virus Sequences

Demidkin, S.; Shwarts, M.; Chakravarty, A.; Joseph-McCarthy, D.

10.1101/2022.01.25.477734 — bioinformatics — Posted on 2022-01-27

619 Preparing for the unknown: How working memory provides a link between perception and anticipated action

Roesner, M.; Sabo, M.; Klatt, L.-I.; Wascher, E.; Schneider, D.

10.1101/2022.01.25.477681 — neuroscience — Posted on 2022-01-27

620 Temporal learning modulates post-interval ERPs in a categorization task with hidden reference durations.

Silvestrin, M.; Claessens, P. M. E.; Cravo, A. M.

10.1101/2022.01.25.477745 — neuroscience — Posted on 2022-01-27

621 Weighting of celestial and terrestrial cues in the monarch butterfly central complex

Nguyen, T. A. T.; Beetz, M. J.; Merlin, C.; Pfeiffer, K.; el Jundi, B.

10.1101/2022.01.25.477695 — neuroscience — Posted on 2022-01-27

622 A bite force database of 654 insect species

Ruehr, P. T.; Edel, C.; Frenzel, M.; Blanke, A.

10.1101/2022.01.21.477193 — zoology — Posted on 2022-01-27

623 Physiological Responses to Caprine Coccidiosis During a 100-year Rain Event in Oklahoma: An Opportunistic Case Study with a implications for climate change and clinical diagnosis.

McCallum, M. L.; Tilahun, Y.; Quijada Pinango, J.; Wang, Z.

10.1101/2022.01.25.477737 — physiology — Posted on 2022-01-27

624 Establishment and characterization of novel autologous pair primary cultures from two Indian non-habitual tongue carcinoma patients

Dwivedi, N.; G, C.; Pillai, V.; Kuriakose, M. A.; Suresh, A.; Das, M.

10.1101/2022.01.25.477260 — cancer biology — Posted on 2022-01-27

625 A cellular hierarchy framework for understanding heterogeneity and predicting drug response in AML

Zeng, A. G. X.; Bansal, S.; Jin, L.; Mitchell, A.; Chen, W. C.; Abbas, H. A.; Chan-Seng-Yue, M.; Voisin, V.; van Galen, P.; Tierens, A.; Cheok, M.; Preudhomme, C.; Dombret, H.; Daver, N.; Futreal, P. A.; Minden, M. D.; Kennedy, J. A.; Wang, J. C. Y.; Dick, J. E.

10.1101/2022.01.25.476266 — cancer biology — Posted on 2022-01-27

626 Reversible adhesion by type IV pili leads to formation of irreversible localized clusters

Kierbel, A.; Pepe, M. V.; Dea, C.; Genskowsky, C.; Capasso, D.; Jäger, A. V.; Peruani, F.

10.1101/2022.01.24.477649 — biophysics — Posted on 2022-01-27

627 Bistable nerve conduction

Zhang, Z.; Qu, Z.

10.1101/2022.01.25.477744 — biophysics — Posted on 2022-01-27

628 Soft topographical patterns trigger a stiffness-dependent cellular response to contact guidance

Comelles, J.; Fernandez-Majada, V.; Acevedo, V.; Rebollo-Calderon, B.; Elena Martinez, E.

10.1101/2022.01.25.477731 — biophysics — Posted on 2022-01-27

629 Needler: An Algorithm to Develop a Comprehensive Targeted MS Method Capable of Monitoring the Human Proteome

Ready, D. B.; Potts, G. K.

10.1101/2022.01.25.477578 — bioinformatics — Posted on 2022-01-27

630 hudson: A User-Friendly R Package to Extend Manhattan Plots

Lucas, A.; Verma, A.; Ritchie, M. D.

10.1101/2022.01.25.474274 — bioinformatics — Posted on 2022-01-27

631 CavitySpace: A database of potential ligand binding sites in the human proteome

Wang, S.; Lin, H.; Huang, Z.; He, Y.; Deng, X.; Xu, Y.; Pei, J.; Lai, L.

10.1101/2022.01.25.477691 — bioinformatics — Posted on 2022-01-27

632 GAIT BIOMECHANICS OF RABBITS WITH EITHER ACHILLES OR TIBIALIS CRANIALIS ARTIFICIAL TENDONS

Hall, P.; Stubbs, C.; Pedersen, A. P.; Billings, C. J.; Stephenson, S. M.; Greenacre, C. B.; Anderson, D.; Crouch, D. L.

10.1101/2022.01.25.477740 — bioengineering — Posted on 2022-01-27

633 Transmission of SARS-CoV-2 from humans to animals and potential host adaptation

Tan, C. C.; Lam, S. D.; Richard, D.; Owen, C.; Berchtold, D.; Orengo, C.; Surendran Nair, M.; Kuchipudi, S. V.; Kapur, V.; van Dorp, L.; Balloux, F.

10.1101/2020.11.16.384743 — genomics — Posted on 2022-01-27

634 A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations

Eccleston, R. C.; Manko, E.; Campino, S.; Clark, T. G.; Furnham, N.

10.1101/2022.01.25.477595 — evolutionary biology — Posted on 2022-01-27

635 Zebrafish caudal fin amputation induces a metabolic switch necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration

Brandao, A. S.; Borbinha, J.; Pereira, T.; Brito, P. H.; Lourenco, R.; Bensimon-Brito, A.; Jacinto, A.

10.1101/2022.01.26.477895 — developmental biology — Posted on 2022-01-27

636 The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

Hirano, M.; Galarza-Munoz, G.; Schott, G.; Wang, L.; Nagasawa, C.; Antonia, A. L.; Jain, V.; Yu, X.; Widen, S. G.; Briggs, F. B.; Gregory, S. G.; Ko, D. C.; Fagg, W. S.; Bradrick, S.; Garcia-Blanco, M. A.

10.1101/2022.01.25.477795 — molecular biology — Posted on 2022-01-27

637 The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses

Sodeik, B.; Serrero, M. C.; Girault, V.; Weigang, S.; Greco, T. M.; Ramos Nascimento, A.; Anderson, F.; Piras, A.; Hickford Martinez, A.; Hertzog, J.; Binz, A.; Pohlmann, A.; Prank, U.; Rehwinkel, J.; Bauerfeind, R.; Cristea, I. M.; Pichlmair, A.; Kochs, G.

10.1101/2022.01.25.477704 — microbiology — Posted on 2022-01-27

638 Inhibitory IL-10-producing CD4+ T cells develop in a T-bet-dependent manner and facilitate cytomegalovirus persistence via coexpression of arginase-1

Clement, M.; Ladell, K.; Miners, K. L.; Marsden, M.; Chapman, L.; Cardus-Figueras, A.; Scott, J.; Andrews, R.; Clare, S.; Kriukova, V. V.; Lupyr, K. R.; Britanova, O. V.; Withers, D. R.; Chudakov, D. M.; Jones, S. A.; Price, D. A.; Humphreys, I.

10.1101/2022.01.25.477742 — immunology — Posted on 2022-01-27

639 Stimulus Whitening Improves the Efficiency of Reverse Correlation

Compton, A.; Roop, B. W.; Parrell, B.; Lammert, A. C.

10.1101/2022.01.25.477706 — neuroscience — Posted on 2022-01-27

640 Brain perivascular space imaging across the human lifespan

Lynch, K. M.; Sepehrband, F.; Toga, A. W.; Choupan, J.

10.1101/2022.01.25.475887 — neuroscience — Posted on 2022-01-27

641 Using the glial mitochondrial machinery to prevent multilevel dysfunctions observed in a mouse model of Alzheimer s disease

Rosenberg, N.; Reva, M.; Restivo, L.; Briquet, M.; Bernardinelli, Y.; Rocher, A.-B.; Markram, H.; Chatton, J.-Y.

10.1101/2022.01.25.477694 — neuroscience — Posted on 2022-01-27

642 Neural Basis of The Double Drift Illusion

Steinberg, N. J.; Roth, Z. N.; Movshon, J. A.; Merriam, E.

10.1101/2022.01.25.477714 — neuroscience — Posted on 2022-01-27

643 A network information theoretic framework to characterise muscle synergies in space and time

O'Reilly, D.; Delis, I.

10.1101/2021.10.15.464450 — neuroscience — Posted on 2022-01-27

644 Multi-echo Quantitative Susceptibility Mapping: How to Combine Echoes for Accuracy and Precision

Biondetti, E.; Karsa, A.; Grussu, F.; Battiston, M.; Yiannakas, M. C.; Thomas, D. L.; Shmueli, K.

10.1101/2021.06.14.448385 — neuroscience — Posted on 2022-01-27

645 The vagus nerve mediates the stomach-brain coherence in rats

Cao, J.; Wang, X.; Chen, J.; Zhang, N.; Liu, Z.

10.1101/2022.01.25.477693 — neuroscience — Posted on 2022-01-27

646 CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington's disease

Yu, D.; Zarate, N.; White, A.; Coates, D.; Tsai, W.; Nanclares, C.; Cuccu, F.; Yue, J. S.; Brown, T. G.; Mansky, R.; Jiang, K.; Kim, H.; Nichols-Meade, T.; Larson, S. N.; Gundry, K.; Zhang, Y.; Tomas-Zapico, C.; Lucas, J. J.; Benneyworth, M.; Öz, G.; Cvetanovic, M.; Araque, A.; Gomez-Pastor, R.

10.1101/2020.10.29.359380 — neuroscience — Posted on 2022-01-27

647 Toll Like Receptor 9 Pathway Mediates Schlafen+-MDSC Polarization During Helicobacter-Induced Gastric Metaplasias

Ding, L. L.; Chakrabarti, J. L.; Sheriff, S.; Li, Q.; Thi Hong, H. N.; Sontz, R. A.; Mendoza, Z. E.; Schreibeis, A.; Helmrath, M. A.; Zavros, Y.; Merchant, J. L.

10.1101/2022.01.25.477562 — cancer biology — Posted on 2022-01-27

648 Slow-cycling cells in glioblastoma: a specific population in the cellular mosaic of cancer stem cells

Yang, C.; Tian, G.; Dajac, M.; Doty, A.; Wang, S.; Lee, J.-H.; Rahman, M.; Huang, J.; Reynolds, B. A.; Sarkisian, M. R.; Mitchell, D.; Deleyrolle, L. P.

10.1101/2022.01.25.477703 — cancer biology — Posted on 2022-01-27

649 A comprehensive evaluation of consensus spectrum generation methods in proteomics

Luo, X.; Bittremieux, W.; Griss, J.; Deutsch, E. W.; Sachsenberg, T.; Levitsky, L. I.; Ivanov, M. V.; Bubis, J. A.; Gabriels, R.; Webel, H.; Sanchez, A.; Bai, M.; Käll, L.; Perez-Riverol, Y.

10.1101/2022.01.25.477699 — bioinformatics — Posted on 2022-01-27

650 TooT-SC: Predicting Eleven Substrate Classes of Transmembrane Transport Proteins

Alballa, M.; Butler, G.

10.1101/2022.01.25.477715 — bioinformatics — Posted on 2022-01-27

651 Selecting an effective amplitude threshold for neural spike detection

zhang, z.; Constandinou, T.

10.1101/2022.01.25.477685 — bioengineering — Posted on 2022-01-27

652 Essential bromodomain TcBDF2 as a drug target against Chagas disease

Pezza, A.; Tavernelli, L. E.; Alonso, V. L.; Perdomo, V. G.; Gabarro, R. C.; Prinjha, R.; Rodriguez Araya, E.; Rioja, I.; Docampo, R.; Calderon, F.; Martin, J. J.; Serra, E.

10.1101/2022.01.25.477728 — cell biology — Posted on 2022-01-27

653 Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosis

Shallberg, L. A.; Phan, A. T.; Christian, D. A.; Perry, J. A.; Haskins, B. E.; Beiting, D. P.; Harris, T. H.; Koshy, A. A.; Hunter, C. A.

10.1101/2022.01.25.477653 — immunology — Posted on 2022-01-27

654 PIMT suppresses endothelial activation and vascular inflammation through methylation of TRAF6

Sun, J.; Zhang, C.; Guo, Z.-F.; Yi, B.; Kazama, K.; Liu, W.; Sun, X.; Wang, L.; Yang, X.-F.; Summer, R. S.

10.1101/2022.01.25.477656 — physiology — Posted on 2022-01-27

655 Genome-wide analysis of Schistosoma mansoni reveals population structure and praziquantel drug selection pressure within Ugandan hot-spot communities

Vianney, T. J.; Berger, D.; Doyle, S.; Sankaranarayanan, G.; Serubanja, J.; Nakawungu, P. K.; Besigye, F.; Sanya, R.; Holroyd, N.; Allan, F.; Webb, E.; Elliott, A.; Berriman, M.; Cotton, J.

10.1101/2022.01.25.477652 — genomics — Posted on 2022-01-27

656 Modelling eDNA transport in river networks reveals highly resolved spatio-temporal patterns of freshwater biodiversity

Carraro, L.; Blackman, R. C.; Altermatt, F.

10.1101/2022.01.25.475970 — ecology — Posted on 2022-01-27

657 Integrative nascent RNA methods to reveal cell-type specific transcription programs in peripheral blood and its derivative cells

Kim, S. S.-Y.; Kim, E.; Kimm, A.; Kwak, H.

10.1101/836841 — molecular biology — Posted on 2022-01-27

658 PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8+ T cells.

Hope, J. L.; Otero, D. C.; Bae, E.-A.; Stairiker, C. J.; Palete, A. B.; Faso, H. A.; Henriquez, M. L.; Seo, H.; Lei, X.; Wang, E. S.; Tinoco, R.; Campos, A. R.; Yin, J.; Adams, P. D.; Rao, A.; Bradley, L. M.

10.1101/2022.01.24.477602 — immunology — Posted on 2022-01-27

659 A murine Wac model exhibits phenotypes relevant to DeSanto-Shinawi Syndrome

Stafford, A. M.; Pacheco-Vergara, M.; Uhl, K. L.; Jager, T. E.; Li, X.; Jeong, J.; Vogt, D.

10.1101/2022.01.24.477600 — neuroscience — Posted on 2022-01-27

660 Dynamic observation of 2H labeled compounds in the human brain with 1H versus 2H magnetic resonance spectroscopy at 9.4T

Ruhm, L.; Ziegs, T.; Wright, A. M.; Mathy, C. S.; Murali-Manohar, S.; Dorst, J.; Avdievich, N.; Henning, A.

10.1101/2022.01.24.477582 — neuroscience — Posted on 2022-01-27

661 Reticulospinal drive increases maximal motoneuron output in humans

Skarabot, J.; Folland, J. P.; Holobar, A.; Baker, S. N.; Del Vecchio, A.

10.1101/2022.01.24.477080 — physiology — Posted on 2022-01-27

662 Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats

Chellian, R.; Behnood-Rod, A.; Wilson, R.; Lin, K.; King, G.; Ruppert-Gomez, M.; Teter, A.; Bruijnzeel, A.

10.1101/2022.01.24.477590 — pharmacology and toxicology — Posted on 2022-01-27

663 Hijacking Methyl Reader proteins for Nuclear-Specific Protein Degradation

Nalawansha, D. A.; Li, K.; Hines, J.; Crews, C. M.

10.1101/2022.01.24.477424 — pharmacology and toxicology — Posted on 2022-01-27

664 A real-time cellular thermal shift assay (RT-CETSA) to monitor target engagement

Sanchez, T. W.; Ronzetti, M. H.; Owens, A. E.; Antony, M.; Voss, T.; Wallgren, E.; Talley, D.; Balakrishnan, K.; Rai, G.; Marugan, J. J.; Michael, S.; Baljinnyam, B.; Southall, N.; Simeonov, A.; Henderson, M. J.

10.1101/2022.01.24.477382 — pharmacology and toxicology — Posted on 2022-01-27

665 Deconstructing replicative senescence heterogeneity of human mesenchymal stem cells at single cell resolution reveals therapeutically targetable senescent cell sub-populations

Taherian Fard, A.; Leeson, H.; Aguado Perez, J.; Pietrogrande, G.; Power, D.; Gomez Inclan, C.; Zheng, H.; Nelson, C. B.; Soheilmoghaddam, F.; Glass, N.; Dharmaratne, M.; Watson, E. R.; Lu, J.; Martin, S.; Pickett, H.; Cooper-White, J.; Wolvetang, E. J.; Mar, J. C.

10.1101/2022.01.24.476823 — bioinformatics — Posted on 2022-01-27

666 RecombineX: a generalized computational framework for automatic high-throughput gamete genotyping and tetrad-based recombination analysis

Li, J.; Llorente, B.; Liti, G.; Yue, J.-X.

10.1101/2022.01.24.477452 — bioinformatics — Posted on 2022-01-27

667 Genomic analyses identify significant molecules and biological processes in colorectal cancer cells with DNA damage

Guo, H.; Zhang, M.; Gu, H.; Liu, J.

10.1101/2022.01.24.477593 — bioinformatics — Posted on 2022-01-27

668 Bioinspired Stretchable Transducer for Wearable Continuous Monitoring of Respiratory Patterns in Humans and Animals

Cotur, Y.; Olenik, S.; Asfour, T.; Bruyns-Haylett, M.; Kasimatis, M.; Tanriverdi, U.; Gonzalez Macia, M. L.; Lee, H. S.; Kozlov, A. S.; Guder, F.

10.1101/2022.01.24.477637 — bioengineering — Posted on 2022-01-27

669 The evolutionary history of mammoth wasps (Hymenoptera: Scoliidae)

Khouri, Z.; Gillung, J. P.; Kimsey, L. S.

10.1101/2022.01.24.474473 — evolutionary biology — Posted on 2022-01-27

670 Leveraging CD39 To Identify Tumor-Reactive CD8 T cells In Human Lung Cancer

Chow, A.; Uddin, F. Z.; Mangarin, L.; Rizvi, H.; Dobrin, A.; Tischfield, S. E.; Quintanal-Villalonga, A.; Chan, J. M.; Shah, N. S.; Allaj, V.; Manoj, P.; Mattar, M.; Meneses, M.; Landau, R.; Ward, M.; Kulick, A.; Kwong, C.; Wierzbicki, M.; Yavner, J.; Chavan, S.; Farillas, A.; Liu, M.; Holland, A.; Ciampricotti, M.; Hirschhorn-Cymerman, D.; Richards, A.; Donoghue, M. T. A.; Heller, G.; Klebanoff, C. A.; Hellmann, M. D.; de Stanchina, E.; Sen, T.; Wolchok, J. D.; Merghoub, T.; Rudin, C. M.

10.1101/2022.01.24.477554 — immunology — Posted on 2022-01-27

671 Computational modeling of macrophage iron sequestration during host defense against Aspergillus

Adhikari, B.; Scindia, Y.; Sordo Vieira, L.; de Assis Lopes Ribeiro, H.; Masison, J.; Yang, N.; Fonseca, L.; Wheeler, M.; Knapp, A.; Mei, Y.; Helba, B.; Atkinson, C.; Schroeder, W.; Mehrad, B.; Laubenbacher, R.

10.1101/2022.01.24.477648 — immunology — Posted on 2022-01-27

672 Heritability of hippocampal functional and microstructural organisation

Bayrak, S.; Vos de Wael, R.; Schaare, H. L.; Caldairou, B.; Bernasconi, A.; Bernasconi, N.; Bernhardt, B. C.; Valk, S. L.

10.1101/2021.11.10.468049 — neuroscience — Posted on 2022-01-27

673 BOLD cofluctuation 'events' are predicted from static functional connectivity

Ladwig, Z.; Seitzman, B. A.; Dworetsky, A.; Yu, Y.; Adeyemo, B.; Smith, D. M.; Petersen, S. E.; Gratton, C.

10.1101/2022.01.24.477543 — neuroscience — Posted on 2022-01-27

674 Impact of a native hemiparasitic plant on invasive and native hosts in the field.

Cirocco, R. M.; Watling, J. R.; Facelli, J. M.

10.1101/2022.01.22.477372 — plant biology — Posted on 2022-01-27

675 Do water and host size interactively affect the impact of a native hemiparasite on a major invasive legume?

Cirocco, R. M.; Facelli, E.; Facelli, J. M.

10.1101/2022.01.22.477374 — plant biology — Posted on 2022-01-27

676 Metabolism is a major driver of hydrogen isotope fractionation recorded in tree-ring glucose of Pinus nigra

Wieloch, T.; Grabner, M.; Augusti, A.; Serk, H.; Ehlers, I.; Yu, J.; Schleucher, J.

10.1101/2021.07.22.453377 — biophysics — Posted on 2022-01-27

677 DeepPlnc: Discovering plant lncRNAs through multimodal deep learning on sequential data

Ritu, ; Gupta, S.; Sharma, N. K.; Shankar, R.

10.1101/2021.12.10.472074 — bioinformatics — Posted on 2022-01-27

678 Smart sealants for prevention and monitoring of gastrointestinal anastomotic leaks using portable smartphone-controlled ultrasound transducers

Anthis, A. H. C.; Abundo, M. P.; Neuer, A. L.; Tsolaki, E.; Rosendorf, J.; Rduch, T.; Starsich, F.; Liska, V.; Schlegel, A. A.; Shapiro, M. G.; Herrmann, I. K.

10.1101/2022.01.24.477460 — bioengineering — Posted on 2022-01-27

679 Intermittent Bulk Release of Human Cytomegalovirus

Flomm, F. J.; Soh, T. K.; Schneider, C.; Wedemann, L.; Britt, H. M.; Thalassinos, K.; Pfitzner, S.; Reimer, R.; Gruenewald, K.; Bosse, J. B.

10.1101/2020.12.31.424954 — microbiology — Posted on 2022-01-27

680 Caspase-1-driven neutrophil pyroptosis promotes an incomplete NETosis upon Pseudomonas aeruginosa infection

Santoni, K.; Pericat, D.; Pinilla, M.; Bagayoko, S.; Hessel, A.; Leon-Ycaza, S. A.; Bellard, E.; Mazeres, S.; Doz-Deblauwe, E.; Winter, N.; Paget, C.; Girard, J.-P.; Cougoule, C.; Poincloux, R.; Lamkanfi, M.; Lefrancais, E.; Meunier, E.; Planes, R.

10.1101/2021.06.28.450116 — immunology — Posted on 2022-01-27

681 Ventral hippocampus-lateral septum circuitry promotes foraging-related memory

Decarie-Spain, L.; Liu, C. M.; Tierno Lauer, L.; Klug, M.; Gianatiempo, I. H.; Suarez, A. N.; Cortella, A. M.; Noble, E. E.; Hahn, J. D.; Davis, E. A.; Kanoski, S. E.

10.1101/2020.06.16.155721 — neuroscience — Posted on 2022-01-27

682 Control of Ca2+ signals by astrocyte nanoscale morphology at tripartite synapses

Denizot, A.; Arizono, M.; Nägerl, V.; Berry, H.; De Schutter, E.

10.1101/2021.02.24.432635 — neuroscience — Posted on 2022-01-27

683 Microbial colonization of tannin-rich tropical plants: interplay between degradability, methane production and tannin disappearance in the rumen

Rira, M.; Morgavi, D. P.; Popova, M.; Maxin, G.; Doreau, M.

10.1101/2021.08.12.456105 — zoology — Posted on 2022-01-27

684 Identifying mutant-specific multi-drug combinations using Comparative Network Reconstruction

Bosdriesz, E.; Fernandes Neto, J. M.; Sieber, A.; Bernards, R. R.; Bluthgen, N.; Wessels, L.

10.1101/2020.12.17.423240 — systems biology — Posted on 2022-01-27

685 Jurassic NLR: conserved and dynamic evolutionary features of the atypically ancient immune receptor ZAR1

Adachi, H.; Sakai, T.; Kourelis, J.; Pai, H.; Gonzalez Hernandez, J. L.; Maqbool, A.; Kamoun, S.

10.1101/2020.10.12.333484 — plant biology — Posted on 2022-01-27

686 A timer gene network is spatially regulated by the terminal system in the Drosophila embryo

Clark, E.; Battistara, M.; Benton, M. A.

10.1101/2022.01.26.477848 — developmental biology — Posted on 2022-01-27

687 The small GTPase Arf1 regulates ATP synthesis and mitochondria homeostasis by modulating fatty acid metabolism

Enkler, L.; Pennauer, M. V.; Szentgyörgyi, V.; Prescianotto-Baschong, C.; Riezman, I.; Wiesyk, A.; Kucharczyk, R.; Spiess, M.; Riezman, H.; Spang, A.

10.1101/2022.01.26.477847 — cell biology — Posted on 2022-01-27

688 Entorhinal layer 6b subplate neurons govern spatial learning and memory

Ben Simon, Y.; Kaefer, K.; Velicky, P.; Csicsvari, J.; Danzl, J. G.; Jonas, P.

10.1101/2022.01.26.477814 — neuroscience — Posted on 2022-01-27

689 Data-driven modelling captures dynamics of the circadian clock ofNeurospora crassa

Singh, A.; Li, C.; Diernfellner, A. C. R.; Hoefer, T.; Brunner, M.

10.1101/2022.01.24.477555 — systems biology — Posted on 2022-01-27

690 Reconstitution of muscle cell microtubule organization in vitro

Heald, R.; Nadkarni, A.

10.1101/2022.01.26.477920 — cell biology — Posted on 2022-01-27

691 The way of the light: how visual information reaches the auditory cortex in congenitally deaf adults

Giorjiani, G. M.; Tal, Z.; Nili, H.; Bi, Y.; Fang, F.; Almeida, J.

10.1101/2022.01.25.477765 — neuroscience — Posted on 2022-01-27

692 Enhanced anticipatory biasing of visuospatial attention in deaf native-signing adults indexed by alpha-band (8-14 Hz) oscillatory neural activity

DeAndrea-Lazarus, I. A.; Freedman, E. G.; Xu, J.; Prinsloo, K. D.; Sargeant, M. M.; Foxe, J. J.

10.1101/2022.01.25.477746 — neuroscience — Posted on 2022-01-27

693 Interrogation of genome-wide, experimentally dissected gene regulatory networks reveals mechanisms underlying dynamic cellular state control

Tan, X.; Worley, J.; Turunen, M.; Wong, K.; Fernandez, E. C.; Paull, E.; Jones, S.; Wang, J.; Noh, H.; Salvatori, B.; Chavez, A.; Califano, A.

10.1101/2021.06.28.449297 — systems biology — Posted on 2022-01-26

694 Humans recognize affective cues in primate vocalizations: Acoustic and phylogenetic perspectives

Debracque, C.; Clay, Z.; Gruber, T.; Grandjean, D.

10.1101/2022.01.26.477864 — animal behavior and cognition — Posted on 2022-01-27

695 Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma

Yang, Y.; Oellerich, T.; Chen, P.; Bolomsky, A.; Ceribelli, M.; Haupl, B.; Wright, G. W.; Phelan, J. D.; Huang, D. W.; Lord, J. W.; Van Winkle, C. K.; Yu, X.; Wisnieski, J.; Wang, J. Q.; Tosto, F. A.; Beck, E.; Wilson, K.; McKnight, C.; Travers, J.; Klumpp-Thomas, C.; Smith, G. A.; Pittaluga, S.; Maric, I.; Kazandjian, D.; Thomas, C. J.; Young, R. M.

10.1101/2021.11.28.470260 — cancer biology — Posted on 2022-01-26

696 Decomposing virulence to understand bacterial clearance in persistent infections

Acuna Hidalgo, B.; Silva, L. M.; Franz, M.; Regoes, R. R.; Armitage, S. A. O.

10.1101/2021.03.29.437521 — evolutionary biology — Posted on 2022-01-26

697 Nos2-/- mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis

Poh, X. Y.; Hong, J. M.; Bai, C.; Miow, Q. H.; Thong, P. M.; Wang, Y.; Rajarethinam, R.; Ding, C. S. L.; Ong, C. W. M.

10.1101/2021.08.15.456427 — microbiology — Posted on 2022-01-26

698 Visual discrimination of optical material properties: a large-scale study

Sawayama, M.; Dobashi, Y.; Okabe, M.; Hosokawa, K.; Koumura, T.; Saarela, T.; Olkkonen, M.; Nishida, S.

10.1101/800870 — neuroscience — Posted on 2022-01-26

699 Dynamics of visual perceptual decision-making in freely behaving mice

You, W.-K.; Mysore, S. P.

10.1101/2020.02.20.958652 — neuroscience — Posted on 2022-01-26

700 Sensory experience modulates the reorganisation of temporal auditory regions for executive processing

Manini, B.; Vinogradova, V.; Woll, B.; Cameron, D.; Eimer, M.; Cardin, V.

10.1101/2021.02.08.430248 — neuroscience — Posted on 2022-01-26

701 An epigenome atlas of neural progenitors within the embryonic mouse forebrain

Rhodes, C. T.; Thompson, J. J.; Mitra, A.; Asokumar, D.; Lee, D. R.; Lee, D. J.; Zhang, Y.; Jason, E.; Dale, R. K.; Rocha, P. P.; Petros, T. J.

10.1101/2021.03.21.436353 — neuroscience — Posted on 2022-01-26

702 Small extracellular vesicles from young mice prevent frailty, improve healthspan and decrease epigenetic age in old mice.

Sanz-Ros, J.; Mas-Bargues, C.; Monleon, D.; Gordevicius, J.; Brooke, R. T.; Dromant, M.; Derevyanko, A.; Guio-Carrion, A.; Roman-Dominguez, A.; Romero-Garcia, N.; Ingles, M.; Blasco, M. A.; Horvath, S.; Vina, J.; Borras, C.

10.1101/2021.07.29.454302 — physiology — Posted on 2022-01-26

703 The relaxin receptor RXFP1 signals through a mechanism of autoinhibition

Erlandson, S. C.; Rawson, S.; Brock, K. P.; Liu, X.; Paulo, J. A.; Mintseris, J.; Gygi, S. P.; Marks, D. S.; Cong, X.; Kruse, A. C.

10.1101/2022.01.22.477343 — pharmacology and toxicology — Posted on 2022-01-26

704 Structure of ATP synthase under strain during catalysis

Guo, H.; Rubinstein, J. L.

10.1101/2022.01.24.477618 — biophysics — Posted on 2022-01-26

705 Pout2Prot: an efficient tool to create protein (sub)groups from Percolator output files

Schallert, K.; Verschaffelt, P.; Mesuere, B.; Benndorf, D.; Martens, L.; Van Den Bossche, T.

10.1101/2021.08.11.455803 — bioinformatics — Posted on 2022-01-26

706 Built on sand: the shaky foundations of simulating single-cell RNA sequencing data

Crowell, H. L.; Leonardo, S. X. M.; Soneson, C.; Robinson, M. D.

10.1101/2021.11.15.468676 — bioinformatics — Posted on 2022-01-26

707 Development and validation of nanobodies specifically targeting the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3)

Smith, C. N.; Kihn, K.; Williamson, Z. A.; Chernyavskyay, Y.; Chow, K. M.; Hersh, L. B.; Korotkov, K. V.; Deredge, D.; Blackburn, J. S.

10.1101/2020.10.02.311787 — biochemistry — Posted on 2022-01-26

708 Interaction of the Proline-Rich Domain of Fission Yeast WASp (Ws1p1) with Actin Filaments

Pollard, T. D.; Rosenbloom, A. D.

10.1101/2022.01.26.477833 — biochemistry — Posted on 2022-01-26

709 Acoustic and postural displays in a miniature and transparent teleost fish, Danionella dracula

Tatarsky, R. L.; Guo, Z.; Campbell, S. C.; Kim, H.; Fang, W.; Perelmuter, J. T.; Schuppe, E. R.; Reeve, H. K.; Bass, A. H.

10.1101/2021.11.10.468077 — animal behavior and cognition — Posted on 2022-01-26

710 Transcriptional mapping of the macaque retina and RPE-choroid reveals conserved inter-tissue transcription drivers and signaling pathways

Mungale, A.; McGaughey, D. M.; Zhang, C.; Yousaf, S.; Liu, J.; Brooks, B. P.; Maminishkis, A.; Fufa, T. D.; Hufnagel, R. B.

10.1101/2022.01.21.477280 — genomics — Posted on 2022-01-26

711 Actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction

Chen, W.; He, B.

10.1101/2021.03.07.434309 — developmental biology — Posted on 2022-01-26

712 Distinct developmental mechanisms influence sexual dimorphisms in the milkweed bug Oncopeltus fasciatus

Just, J.; Laslo, M.; Lee, Y. J.; Yarnell, M. C.; Zhang, Z.; Angelini, D. R.

10.1101/2021.05.12.443917 — developmental biology — Posted on 2022-01-26

713 Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to cell-cell adhesion

Kinoshita, N.; Yamamoto, T. S.; Yasue, N.; Takagi, C.; Fujimori, T.; Ueno, N.

10.1101/2020.10.04.323436 — cell biology — Posted on 2022-01-26

714 Pseudomonas aeruginosa utilises host-derived polyamines to facilitate antimicrobial tolerance

Hasan, C. M.; Green, A.; Cox, A. A.; White, J.; Jones, T.; Winstanley, C.; Kadioglu, A.; Wright, M.; Neill, D. R.; Fothergill, J. L.

10.1101/2021.12.15.472801 — microbiology — Posted on 2022-01-26

715 No need to choose: independent regulation of cognitive stability and flexibility challenges the stability-flexibility tradeoff

Geddert, R. M.; Egner, T.

10.1101/2021.08.10.455850 — neuroscience — Posted on 2022-01-26

716 Assigning metabolic rate measurements to torpor and euthermy in heterothermic endotherms: 'torpor', a new package for R.

Fasel, N. J.; Vullioud, C.; Genoud, M.

10.1101/717603 — physiology — Posted on 2022-01-26

717 Decellularized Normal and Tumor Extracellular Matrix as Scaffold for Cancer Organoid Cultures of Colorectal Peritoneal Metastases

Varinelli, L.; Guaglio, M.; Brich, S.; Zanutto, S.; Belfiore, A.; Zanardi, F.; Iannelli, F.; Oldani, A.; Costa, E.; Chighizola, M.; Minardi, S. P.; Fortuzzi, S.; Filugelli, M.; Garzone, G.; Pisati, F.; Vecchi, M.; Pruneri, G.; Kusamura, S.; Baratti, D.; Cattaneo, L.; Parazzoli, D.; Podesta, A.; Milione, M.; Deraco, M.; Pierotti, M. A.; Gariboldi, M.

10.1101/2021.07.15.452437 — cancer biology — Posted on 2022-01-26

718 Target-dependent siRNA suppression distinguishes self from non-self endogenous siRNAs in C. elegans germline

Gajic, Z.; Kaur, D.; Gu, S. G.

10.1101/2022.01.25.477739 — molecular biology — Posted on 2022-01-26

719 Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

Flynn, J. M.; Samant, N.; Schneider-Nachum, G.; Barkan, D. T.; Yilmaz, N. K.; Schiffer, C. A.; Moquin, S. A.; Dovala, D.; Bolon, D. N. A.

10.1101/2022.01.26.477860 — molecular biology — Posted on 2022-01-26

720 Recommendations for tissue homogenisation and extraction in DNA metabarcoding of Malaise trap samples

Zizka, V. M.; Geiger, M. F.; Hoerren, T.; Kirse, A.; Noll, N. W.; Schaeffler, L.; Scherges, A.; Sorg, M.

10.1101/2022.01.25.477667 — molecular biology — Posted on 2022-01-26

721 Gut bacterial nutrient preferences quantified in vivo

Zeng, X.; Xing, X.; Gupta, M.; Keber, F. C.; Lopez, J. G.; Roichman, A.; Wang, L.; Neinast, M. D.; Donia, M. S.; Wuhr, M.; Jang, C.; Rabinowitz, J.

10.1101/2022.01.25.477736 — molecular biology — Posted on 2022-01-26

722 An LTR retrotransposon in the promoter of a PsMYB10.2 gene associated with the regulation of fruit flesh color in Japanese plum

Fiol, A.; Garcia, S.; Dujak, C.; Pacheco, I.; Infante, R.; Aranzana, M. J.

10.1101/2022.01.26.477575 — molecular biology — Posted on 2022-01-26

723 A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance.

Leshchiner, D.; Rosconi, F.; Sundaresh, B.; Rudmann, E.; Nieto Ramirez, L. M.; Nishimoto, A. T.; Wood, S.; Jana, B.; Bujan, N.; Li, K.; Gao, J.; Frank, M.; Reeve, S. M.; Lee, R. E.; Rock, C. O.; Rosch, J. W.; van Opijnen, T.

10.1101/2022.01.26.477867 — microbiology — Posted on 2022-01-26

724 Transient RNA structures cause aberrant influenza virus replication and innate immune activation

French, H.; Pitre, E.; Oade, M. S.; Elshina, E.; Bisht, K.; Jahun, A.; King, A.; Bauer, D. L. V.; te Velthuis, A. J. W.

10.1101/2022.01.25.476955 — microbiology — Posted on 2022-01-26

725 In vitro activity of ertapenem against Neisseria gonorrhoeae clinical isolates with decreased susceptibility or resistance to extended spectrum cephalosporins in Nanjing, China (2013-2019)

Su, X.-H.; Li, X.; Le, W.-J.; Lou, X.; Genco, C. A.; Rice, P. A.

10.1101/2022.01.25.477800 — microbiology — Posted on 2022-01-26

726 Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells

Glover, G.; Voliotis, M.; Lapinska, U.; Invergo, B.; Soanes, D.; O'Neill, P.; Moore, K.; Nikolic, N.; Petrov, P.; Milner, D.; Roy, S.; Heesom, K.; Richards, T.; tsaneva-atanasova, k.; pagliara, s.

10.1101/2022.01.26.477826 — microbiology — Posted on 2022-01-26

727 Meta-omics-aided isolation of an elusive anaerobic arsenic-methylating soil bacterium

Viacava, K.; Qiao, J.; Janowczyk, A.; Poudel, S.; Jacquemin, N.; Meibom, K. L.; Shrestha, H. K.; Reid, M. C.; Hettich, R. L.; Bernier-Latmani, R.

10.1101/2022.01.25.477449 — microbiology — Posted on 2022-01-26

728 Binocular visual experience and sleep promote visual cortex plasticity and restore binocular vision in a mouse model of amblyopia

Martinez, J. D.; Donnelly, M. J.; Popke, D. S.; Torres, D.; Wilson, L. G.; Brancaleone, W.; Clawson, B. C.; Jiang, S.; Aton, S. J.

10.1101/2022.01.25.477697 — neuroscience — Posted on 2022-01-26

729 Abnormal CCK/CB1R axon targeting in mouse models of dystroglycanopathy

Miller, D. S.; Jahncke, J. N.; Schnell, E.; Wright, K. M.

10.1101/2022.01.26.477791 — neuroscience — Posted on 2022-01-26

730 Cognitive Deficits and Altered Cholinergic Innervation in Young Adult Mice Carrying a Parkinson's Disease LRRK2-G2019S Knockin Mutation

Hussein, A.; Tielemans, A.; Baxter, M. G.; Benson, D. L.; Huntley, G. W.

10.1101/2022.01.26.477929 — neuroscience — Posted on 2022-01-26

731 The Third Transmembrane Domain of Synaptophysin Regulates Initial Fusion Pore Dynamics during Ca2+ -Triggered Exocytosis in Chromaffin cells

Jackson, M. B.; Hsiao, Y.-T.

10.1101/2022.01.26.477821 — biophysics — Posted on 2022-01-26

732 ATP Binding Facilitates Target Search of SWR1 Chromatin Remodeler by Promoting One-Dimensional Diffusion on DNA

Carcamo, C. C.; Poyton, M. F.; Ranjan, A.; Park, G.; Louder, R. K.; Dzu, T.; Wu, C.; Ha, T.

10.1101/2022.01.24.477290 — biophysics — Posted on 2022-01-26

733 S-Acylation Regulates the Membrane Association and Activity of Calpain-5

Gal, J.; Bondada, V.; Mashburn, C. B.; Rodgers, D. W.; Croall, D. E.; Geddes, J. W.

10.1101/2022.01.25.477766 — biochemistry — Posted on 2022-01-26

734 Divergent binding mode for a protozoan BRC repeat to RAD51

Pantelejevs, T.; Hyvonen, M.

10.1101/2022.01.25.477309 — biochemistry — Posted on 2022-01-26

735 Dexamethasone, a direct modulator of AQP2 in Meniere s disease.

Mom, R.; Robert-Paganin, J.; Mom, T.; Chabbert, C.; Rety, S.; Auguin, D.

10.1101/2022.01.25.477763 — biochemistry — Posted on 2022-01-26

736 Investigation of oxidative processes and revealing the changes in purine nucleoside phosphorylase activity levels in model animals in the development of diabetes mellitus

Hovsepyan, L. M.; Ghazaryan, G. S.; Poghosyan, L. G.; Zanginyan, H.

10.1101/2022.01.26.477853 — biochemistry — Posted on 2022-01-26

737 A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene

Ding, Y.; Lang, D.; Yan, J.; Bu, H.; Li, H.; Jiao, K.; Yang, J.; Le, T.; Clark, K.; Ekker, S. C.; Cao, H.; Zhang, Y.; Li, Y.; Glukhov, A. V.; Xu, X. C.

10.1101/2022.01.25.477752 — genetics — Posted on 2022-01-26

738 Yersinia pestis genomes reveal plague in Britain 4,000 years ago

Swali, P.; Schutling, R.; Gilardet, A.; Kelly, M.; Anastasiadou, K.; Glocke, I.; Audsley, T.; Loe, L.; Fernandez-Crespo, T.; Ordono, J.; Walker, D.; Davy, T.; Silva, M.; Hajdinjak, M.; Bergstrom, A.; Booth, T.; Skoglund, P.

10.1101/2022.01.26.477195 — evolutionary biology — Posted on 2022-01-26

739 Deconstructing the role of iron and heme in the structure of healthy human gut microbial communities

Celis Luna, A. I.; Relman, D.; Huang, K. C.

10.1101/2022.01.25.477750 — microbiology — Posted on 2022-01-26

740 SepN is essential for assembly and gating of septal junctions in Nostoc sp. PCC 7120

Kieninger, A.-K.; Tokarz, P.; Weiss, G. L.; Pilhofer, M.; Maldener, I.

10.1101/2022.01.26.477872 — microbiology — Posted on 2022-01-26

741 The Alternative Sigma Factor SigL Influences Clostridioides difficile Toxin Production, Sporulation, and Cell Surface Properties

Clark, A. E.; Adamson, C. C.; Carothers, K. E.; Roxas, B. A. P.; Viswanathan, V.; Vedantam, G.

10.1101/2022.01.26.477884 — microbiology — Posted on 2022-01-26

742 T cell transcription factor expression evolves as adaptive immunity matures in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

Grant, N. L.; Maiello, P.; Klein, E.; Lin, P. L.; Borish, H. J.; Tomko, J.; Frye, L. J.; White, A. G.; Kirschner, D. E.; Mattila, J. T.; Flynn, J. L.

10.1101/2022.01.25.477732 — immunology — Posted on 2022-01-26

743 A quantitative model for the dynamics of target recognition and off-target rejection by the CRISPR-Cas Cascade complex

Rutkauskas, M.; Songailiene, I.; Irmisch, P.; Kemmerich, F. E.; Sinkunas, T.; Siksnys, V.; Seidel, R.

10.1101/2022.01.26.477710 — biophysics — Posted on 2022-01-26

744 SARS-CoV-2 Omicron Variant AI-based Primers

Perez-Romero, C. A.; Tonda, A.; Mendoza-Maldonado, L.; MacSharry, J.; Szafran, J.; Claassen, E.; Garssen, J.; Kraneveld, A. D.; Lopez-Rincon, A.

10.1101/2022.01.21.475953 — bioinformatics — Posted on 2022-01-26

745 Structural diversity of the SARS-CoV-2 Omicron spike

Gobeil, S.; Henderson, R.; Stalls, V.; Janowska, K.; Huang, X.; May, A.; Speakman, M.; Beaudoin, E.; Manne, K.; Li, D.; Parks, R.; Barr, M.; Deyton, M.; Martin, M.; Mansouri, K.; Edwards, R. J.; Sempowski, G. D.; Saunders, K. O.; Wiehe, K.; Williams, W.; Korber, B.; Haynes, B. F.; Acharya, P.

10.1101/2022.01.25.477784 — biochemistry — Posted on 2022-01-26

746 The SARS-CoV-2 protein NSP2 impairs the microRNA-induced silencing capacity of human cells

Zou, L.; Moch, C.; GRAILLE, M.; Chapat, C.

10.1101/2022.01.25.477753 — cell biology — Posted on 2022-01-26

747 Circuit-seq: Circular reconstruction of cut in vitro transposed plasmids using Nanopore sequencing

Emiliani, F. E.; Hsu, I.; McKenna, A.

10.1101/2022.01.25.477550 — molecular biology — Posted on 2022-01-26

748 Despite the odds: formation of the SARS-CoV-2 methylation complex.

Matsuda, A.; Plewka, J.; Chykunova, Y.; Jones, A. N.; Pachota, M.; Rawski, M.; Mourao, A.; Karim, A.; Kresik, L.; Lis, K.; Minia, I.; Hartman, K.; Sonani, R.; Schlauderer, F.; Dubin, G.; Sattler, M.; Suder, P.; Popowicz, G.; Pyrc, K.; Czarna, A.

10.1101/2022.01.25.477673 — microbiology — Posted on 2022-01-26

749 Biodistribution and Environmental Safety of a Live-attenuated YF17D-vectored SARS-CoV-2 Vaccine Candidate

Li, L.-H.; Liesenborghs, L.; Wang, L.; Lox, M.; Yakass, M. B.; Jansen, S.; Rosales Rosas, A. L.; Zhang, X.; Thibaut, H. J.; Teuwen, D.; Neyts, J.; Delang, L.; Dallmeier, K.

10.1101/2022.01.24.477505 — microbiology — Posted on 2022-01-26

750 Wolbachia promotes its own uptake by host cells

Nevalainen, L. B.; Newton, I. L. G.

10.1101/2022.01.24.477646 — microbiology — Posted on 2022-01-26

751 Culture and genomic analysis of Arsenophonus apicola sp. nov. isolated from the honeybee Apis mellifera

Nadal-Jimenez, P.; Siozios, S.; Frost, C. L.; Court, R.; Chrostek, E.; Drew, G. C.; Evans, J. D.; Hawthorne, D. J.; Burritt, J. B.; Hurst, G. D. D.

10.1101/2022.01.26.477889 — microbiology — Posted on 2022-01-26

752 Dysregulation of stress-induced translational control by Porphyromonas gingivalis in host cells

Knowles, A. A.; Campbell, S. G.; Cross, N. A.; Stafford, P.

10.1101/2022.01.24.477647 — microbiology — Posted on 2022-01-26

753 Phenotypic and genotypic characterization of Listeria monocytogenes in clinical ruminant cases in Korea

Kim, J.; Kim, J. W.; Kim, H.-Y.

10.1101/2022.01.24.477645 — microbiology — Posted on 2022-01-26

754 Epigenetic Landscape of HIV Infection in Primary Human Macrophage

Lu, F.; Yi, Y.; Vladimirova, O.; Zhankharia, U.; Collman, R.; Lieberman, P. M.

10.1101/2022.01.25.477798 — microbiology — Posted on 2022-01-26

755 Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

Wu, Y.; Wang, S.; Zhang, Y.; Yuan, L.; Zheng, Q.; Wei, M.; Shi, Y.; Wang, Z.; Ma, J.; Wang, K.; Nie, M.; Xiao, J.; Huang, Z.; Chen, P.; Guo, H.; Lan, M.; Xu, J.; Hou, W.; Hong, Y.; Chen, D.; Sun, H.; Xiong, H.; Zhou, M.; Liu, C.; Guo, W.; Guo, H.; Gao, J.; Li, Z.; Zhang, H.; Wang, X.; Li, S.; Cheng, T.; Zhao, Q.; Chen, Y.; Wu, T.; Zhang, T.; Zhang, J.; Cao, H.; Zhu, H.; Yuan, Q.; Guan, Y.; Xia, N.

10.1101/2022.01.25.477789 — microbiology — Posted on 2022-01-26

756 Phage Paride hijacks bacterial stress responses to kill dormant, antibiotic-tolerant cells

Maffei, E.; Burkolter, M.; Heyer, Y.; Egli, A.; Jenal, U.; Harms, A.

10.1101/2022.01.26.477855 — microbiology — Posted on 2022-01-26

757 Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

Shi, W.; Wang, L.; Zhou, T.; Sastry, M.; Yang, E. S.; Zhang, Y.; Chen, M.; Chen, X.; Choe, M.; Creanga, A.; Leung, K.; Olia, A. S.; Pegu, A.; Rawi, R.; Shen, C.-H.; Stancofski, E.-S. D.; Talana, C. A.; Teng, I.-T.; Wang, S.; Corbett, K. S.; Tsybovsky, Y.; Mascola, J. R.; Kwong, P. D.

10.1101/2022.01.25.477770 — immunology — Posted on 2022-01-26

758 Anti-SARS-CoV-2 swine glyco-humanized polyclonal antibody XAV-19 retains neutralizing activity against SARS-CoV-2 B.1.1.529 (Omicron)

Vanhove, B.; Marot, S. S.; Evanno, G.; Mallet, I.; Rouvray, G.; Shneiker, F.; Mevel, E.; Ciron, C.; Rousse, J.; Royer, P.-J.; Lheriteau, E.; Raffi, F.; Duvaux, O.; Marcelin, A.-G.; Calvez, V.

10.1101/2022.01.26.477856 — immunology — Posted on 2022-01-26

759 Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

Unoh, Y.; Uehara, S.; Nakahara, K.; Nobori, H.; Yamatsu, Y.; Yamamoto, S.; Maruyama, Y.; Taoda, Y.; Kasamatsu, K.; Suto, T.; Kouki, K.; Nakahashi, A.; Kawashima, S.; Sanaki, T.; Toba, S.; Uemura, K.; Mizutare, T.; Ando, S.; Sasaki, M.; Orba, Y.; Sawa, H.; Sato, A.; Sato, T.; Kato, T.; Tachibana, Y.

10.1101/2022.01.26.477782 — biochemistry — Posted on 2022-01-26

760 Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

Yang, X.; Dickmander, R. J.; Bayati, A.; Taft-Benz, S. A.; Smith, J. L.; Wells, C. I.; Madden, E. A.; Brown, J. W.; Lenarcic, E. M.; Yount, B. L.; Chang, E.; Axtman, A. D.; Baric, R. S.; Heise, M. T.; McPherson, P. S.; Moorman, N. J.; Willson, T. M.

10.1101/2022.01.03.474779 — cell biology — Posted on 2022-01-26

761 Somnotate: An accurate, robust, and flexible sleep stage classifier for the experimentalist

Brodersen, P. J. N.; Alfonsa, H.; Krone, L. B.; Blanco-Duque, C.; Fisk, A. S.; Flaherty, S. J.; Guillaumin, M. C. C.; Huang, Y.-G.; Kahn, M. C.; McKillop, L. E.; Milinski, L.; Taylor, L.; Thomas, C. W.; Yamagata, T.; Foster, R. G.; Vyazovskiy, V. V.; Akerman, C. J.

10.1101/2021.10.06.463356 — neuroscience — Posted on 2022-01-26

762 What is valued in conservation? A framework to compare ethical perspectives

Latombe, G.; Lenzner, B.; Schertler, A.; Dullinger, S.; Glaser, M.; Jaric, I.; Pauchard, A.; Wilson, J. R. U.; Essl, F.

10.1101/2020.09.04.282947 — ecology — Posted on 2022-01-26

763 Microbial stowaways - waterbirds as dispersal vectors of aquatic pro- and microeukaryotic communities

Szabo, B.; Szabo, A.; Vad, C. F.; Boros, E.; Lukic, D.; Ptacnik, R.; Marton, Z.; Horvath, Z.

10.1101/2021.10.21.465236 — ecology — Posted on 2022-01-26

764 Cytotoxic T lymphocytes targeting a conserved SARS-CoV-2 spike epitope are efficient serial killers

Fathi, M.; Charley, L.; Cooper, L. J. N.; Varadarajan, N.; Meyer, D.

10.1101/2022.01.24.477535 — immunology — Posted on 2022-01-26

765 Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses

Mao, T.; Goldman-Israelow, B.; Suberi, A.; Zhou, L.; reschke, m.; pena-hernandez, M.; Dong, H.; Homer, R.; Saltzman, M.; Iwasaki, A.

10.1101/2022.01.24.477597 — immunology — Posted on 2022-01-26

766 High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infection

Rinchai, D.; Deola, S.; Zoppoli, G.; Kabeer, B. S. A.; Taleb, S. A.; Pavlovski, I.; Maacha, S.; Gentilcore, G.; Toufiq, M.; Matthew, L.; Liu, L.; Vempalli, F. R.; Mubarak, G.; Lorenz, S.; Sivieri, I.; Cirmena, G.; Dentone, C.; Cuccarolo, P.; Giacobbe, D.; Baldi, F.; Garbarino, A.; Cigolini, B.; Cremonesi, P.; Bedognetti, M.; Ballestrero, A.; Bassetti, M.; Hejblum, B. P.; Augustine, T.; Panhuys, N. V.; Thiebaut, R.; Branco, R.; Chew, T.; Shojaei, M.; Short, K.; Feng, C.; Zughaier, S. M.; Maria, A. D.; Tang, B.; Hssain, A. A.; Bedognetti, D.; Grivel, J.-C.; Chaussabel, D.

10.1101/2021.12.12.472257 — immunology — Posted on 2022-01-26

767 In vivo MR spectroscopy reflects synapse density in a Huntington's disease mouse model

Zarate, N.; Gundry, K.; Yu, D.; Casby, J.; Eberly, L. E.; Oz, G.; Gomez-Pastor, R.

10.1101/2021.10.26.465951 — neuroscience — Posted on 2022-01-26

768 The endoplasmic reticulum membrane protein complex localizes to the mitochondrial - endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei

Iyer, A.; Niemann, M.; Serricchio, M.; Dewar, C. E.; Oeljeklaus, S.; Farine, L.; Warscheid, B.; Schneider, A.; Bütikofer, P.

10.1101/2021.06.17.448810 — biochemistry — Posted on 2022-01-26

769 The limits of evolutionary convergence in sympatry: reproductive interference and developmental constraints leading to local diversity in aposematic signals

Maisonneuve, L.; Elias, M.; Smadi, C.; Llaurens, V.

10.1101/2021.01.22.427743 — evolutionary biology — Posted on 2022-01-26

770 NF90 Interacts with Components of RISC and Modulates Association of Ago2 with mRNA

Grasso, G.; Akkawi, C.; Franckhauser, C.; Nait-Saidi, R.; Bello, M.; Barbier, J.; Kiernan, R.

10.1101/2021.09.23.461467 — molecular biology — Posted on 2022-01-26

771 An Archaea-Specific c-type Cytochrome Maturation Machinery is Crucial for Methanogenesis in Methanosarcina acetivorans

Nayak, D. D.; Gupta, D.; Shalvarjian, K. E.

10.1101/2022.01.26.477811 — microbiology — Posted on 2022-01-26

772 The mycotoxin Beauvericin exhibits immunostimulatory effects on dendritic cells via activating the TLR4 signaling pathway

Yang, X.; Ali, S.; Zhao, M.; Richter, L.; Schafer, V.; Diecks, J. S.; Frank, M.; Qi, J.; Larsen, P. K.; Skerra, J.; Islam, H.; Wachtmeister, T.; Alter, C.; Huang, A.; Bhatia, S.; Kohrer, K.; Kirschning, C.; Weighardt, H.; Kalinke, U.; Kalscheuer, R.; Uhrberg, M.; Scheu, S.

10.1101/2022.01.20.476919 — immunology — Posted on 2022-01-26

773 Immediate and sustained effects of cobalt and zinc-containing pigments on macrophages

Devcic, J.; Dussol, M.; Collin-Faure, V.; Perard, J.; Fenel, D.; Schoehn, G.; Carriere, M.; Rabilloud, T.; Dalzon, B.

10.1101/2021.04.20.440447 — immunology — Posted on 2022-01-26

774 Tracking neural markers of template formation and implementation in attentional inhibition under different distractor consistency

Wen, W.; Huang, Z.; Hou, Y.; Li, S.

10.1101/2021.07.09.451861 — neuroscience — Posted on 2022-01-26

775 iEC7871 Quercus suber model: the first multi-tissue diel cycle genome-scale metabolic model of a woody tree

Cunha, E.; Silva, M.; Chaves, I.; Demirci, H.; Lagoa, D.; Lima, D.; Rocha, M.; Rocha, I.; Dias, O.

10.1101/2021.03.09.434537 — systems biology — Posted on 2022-01-26

776 Y-box binding protein 1 interacts with dengue virus nucleocapsid and mediates viral assembly

Diosa-Toro, M.; Kennedy, D. A.; Chuo, V.; Popov, V. L.; Pompon, J.; Garcia-Blanco, M. A.

10.1101/2022.01.25.477802 — molecular biology — Posted on 2022-01-26

777 Replicative Aging Remodels Cell Wall and is Associated with Increased Intracellular Trafficking in Human Pathogenic Yeasts

Silva, V. K. A.; Bhattacharya, S.; Oliveira, N. K.; Savitt, A. G.; Zamith-Miranda, D.; Nosanchuk, J. D.; Fries, B. C.

10.1101/2022.01.25.477803 — microbiology — Posted on 2022-01-26

778 ARPC5 Isoforms Drive Distinct Arp2/3-dependant Actin Remodeling Events in CD4 T Cells

Sadhu, L.; Tsopoulidis, N.; Laketa, V.; Way, M.; Fackler, O.

10.1101/2022.01.25.477674 — immunology — Posted on 2022-01-26

779 CGRP Administration into the Cerebellum Evokes Migraine-like Behaviors Predominately in Female Mice

Wang, M.; Duong, T.; Rea, B.; Waite, J.; Huebner, M.; Flinn, H.; Russo, A.; Sowers, L. P.

10.1101/2022.01.24.477577 — neuroscience — Posted on 2022-01-26

780 No evidence from complementary data sources of a direct projection from the mouse anterior cingulate area to the hippocampal formation

Andrianova, L.; Yanakieva, S.; Margetts-Smith, G.; Kohli, S.; Brady, E. S.; Aggleton, J.; Craig, M.

10.1101/2022.01.25.477805 — neuroscience — Posted on 2022-01-26

781 SNTA1 GeneRescues Ion Channel Function in Cardiomyocytes Derived from Induced Pluripotent Stem Cells Reprogrammed from Muscular Dystrophy Patients with Arrhythmias

Jalife, J.; Jimenez-Vazquez, E. N.; Arad, M.; Macias, A.; Vera-Pedrosa, M. L.; Cruz, F. M.; Cuttita, A. J.; Monteiro da Rocha, A.; Herron, T. J.; Ponce-Balbuena, D.; Guerrero-Serna, G.; Binah, O.; Michele, D. E.

10.1101/2022.01.25.477696 — cell biology — Posted on 2022-01-26

782 SECEDO: SNV-based subclone detection using ultra-low coverage single-cell DNA sequencing

Rozhonova, H.; Danciu, D.; Stark, S.; Rätsch, G.; Kahles, A.; Lehmann, K.-V.

10.1101/2021.11.08.467510 — bioinformatics — Posted on 2022-01-26

783 3CAC: improving the classification of phages and plasmids in metagenomic assemblies using assembly graphs

Pu, L.; Shamir, R.

10.1101/2021.11.05.467408 — bioinformatics — Posted on 2022-01-26

784 Individual small in-stream barriers contribute little to strong local population genetic structure five strictly aquatic macroinvertebrate taxa

Weiss, M.; Weigand, H.; Leese, F.

10.1101/2020.10.01.322222 — ecology — Posted on 2022-01-26

785 The role of the orbitofrontal cortex in creating cognitive maps

Costa, K. M.; Scholz, R.; Lloyd, K.; Moreno-Castilla, P.; Gardner, M. P. H.; Dayan, P.; Schoenbaum, G.

10.1101/2022.01.25.477716 — neuroscience — Posted on 2022-01-26

786 Temporal perturbations cause movement-context independent but modality-specific sensorimotor adaptation

Schlichting, N.; Kartashova, T.; Wiesing, M.; Zimmermann, E.

10.1101/2021.03.31.437803 — neuroscience — Posted on 2022-01-26

787 Verification of extracellular vesicle-mediated functional mRNA delivery via RNA editing

Somiya, M.; Kuroda, S.

10.1101/2022.01.25.477620 — cell biology — Posted on 2022-01-26

788 The endoplasmic reticulum membrane protein complex (EMC) negatively regulates intestinal homeostasis through the Hippo signaling pathway

Shi, L.; Ma, H.; Zhao, H.; Ma, M.; Wang, J.; Kong, R.; Li, Z.; Ma, R.; Wang, J.-H.; Wu, S.; Dong, M.-Q.; Li, Z.

10.1101/2022.01.25.477727 — cell biology — Posted on 2022-01-26

789 Songbird parents coordinate offspring provisioning at fine spatio-temporal scales.

Baldan, D.; van Loon, E. E.

10.1101/2022.01.24.477548 — animal behavior and cognition — Posted on 2022-01-26

790 Consequences of coupled barriers to gene flow for the build-up of genomic differentiation

Kunerth, H. D.; Bogdanowicz, S. M.; Searle, J. B.; Harrison, R. G.; Coates, B. S.; Kozak, G. M.; Dopman, E. B.

10.1101/2021.09.02.458401 — evolutionary biology — Posted on 2022-01-25

791 Mechanical bistability of the mesoderm epithelium facilitates mesoderm invagination during Drosophila gastrulation

Guo, H.; Swan, M.; He, B.

10.1101/2021.03.18.435928 — developmental biology — Posted on 2022-01-25

792 Study on gene knockout mice and human mutant individual reveals absence of CEP78 causes photoreceptor and sperm flagella impairments

Zhu, T.; Zhang, Y.; Sheng, X.; Zhang, X.; Chen, Y.; Guo, Y.; Qi, Y.; Zhao, Y.; Zhou, Q.; Chen, X.; Guo, X.; Zhao, C.

10.1101/2022.01.25.477668 — developmental biology — Posted on 2022-01-26

793 Cell size homeostasis under the circadian regulation of cell division in cyanobacteria

Kitaguchi, Y.; Tei, H.; Uriu, K.

10.1101/2022.01.25.477786 — cell biology — Posted on 2022-01-26

794 LET-dependence of radiation-induced makers of Immunogenic Cell Death in human cancer cell lines

Ponnaiya, B.; Lomastro, A.; Grabham, P. W.; Garty, g.; Harken, A. D.; Amundson, S. A.; Hillman, E. M. C.; Brenner, D. J.

10.1101/2022.01.25.477729 — cell biology — Posted on 2022-01-26

795 Derlin Dfm1 Employs a Chaperone Function to Resolve Misfolded Membrane Protein Stress

Kandel, R. R.; Jung, J.; Dysau, D.; Kuo, T.; Songster, L.; Aguayo, A.; Duttke, S.; Benner, C.; Neal, S. E.

10.1101/2022.01.25.477788 — cell biology — Posted on 2022-01-26

796 Multiple Ciliary Localization Signals Control INPP5E Ciliary Targeting

Cilleros-Rodriguez, D.; Martin-Morales, R.; Barbeito, P.; Deb Roy, A.; Loukil, A.; Sierra-Rodero, B.; Herranz, G.; Pampliega, O.; Redrejo-Rodriguez, M.; Goetz, S. C.; Izquierdo, M.; Inoue, T.; Garcia-Gonzalo, F. R.

10.1101/2022.01.25.477585 — cell biology — Posted on 2022-01-26

797 Transcriptomics informs design of a planar human enterocyte culture system that reveals metformin enhances fatty acid export

Gomez-Martinez, I.; Bliton, R. J.; Breau, K. A.; Czerwinski, M. J.; Williamson, I. A.; Wen, J.; Rawls, J. F.; Magness, S. T.

10.1101/2022.01.24.477515 — cell biology — Posted on 2022-01-26

798 DciA helicase operators exhibit diversity across bacterial phyla

Blaine, H. C.; Burke, J. T.; Ravi, J.; Stallings, C. L.

10.1101/2022.01.24.477630 — microbiology — Posted on 2022-01-25

799 Comparing the Accuracy and Precision of Multi-echo Combination Methods for Quantitative Susceptibility Mapping Using Laplacian-Based Methods at 3 T

Biondetti, E.; Karsa, A.; Grussu, F.; Battiston, M.; Yiannakas, M. C.; Thomas, D. L.; Shmueli, K.

10.1101/2021.06.14.448385 — neuroscience — Posted on 2022-01-25

800 Whole-brain in vivo base editing reverses autistic-like behaviors in mice

Li, W.; Chen, J.; Peng, W.; Yuan, B.; Han, W.; Yuan, Y.; Xue, Z.; Wang, J.; Chen, Z.; Shan, S.; Zhu, S.; Xu, M.; Cheng, T.; Qiu, Z.

10.1101/2022.01.25.477781 — neuroscience — Posted on 2022-01-25

801 Purkinje Cell Activity in Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques

Avila, E.; Flierman, N.; Holland, P. J.; Roelfsema, P. R.; Frens, M. A.; Badura, A.; De Zeeuw, C. I.

10.1101/2021.03.26.437236 — neuroscience — Posted on 2022-01-25

802 Cortico-Subcortical Interactions in Overlapping Communities of Edge Functional Connectivity

Chumin, E. J.; Faskowitz, J.; Zamani Esfahlani, F.; Jo, Y.; Merritt, H. L.; Tanner, J. C.; Cutts, S. A.; Pope, M. E.; Sporns, O.; Betzel, R.

10.1101/2021.10.19.465016 — neuroscience — Posted on 2022-01-25

803 Look-up and look-down neurons in the mouse visual thalamus during freely moving exploration

Orlowska-Feuer, P.; Ebrahimi, A. S.; Zippo, A. G.; Petersen, R.; Lucas, R. J.; Storchi, R.

10.1101/2022.01.22.477320 — neuroscience — Posted on 2022-01-25

804 A Parsimonious Description of Global Functional Brain Organization in Three Spatiotemporal Patterns

Bolt, T. S.; Nomi, J.; Bzdok, D.; Chang, C.; Yeo, B. T. T.; Uddin, L. Q.; Keilholz, S.

10.1101/2021.06.20.448984 — neuroscience — Posted on 2022-01-25

805 PISCES: A pipeline for the Systematic, Protein Activity-based Analysis of Single Cell RNA Sequencing Data

Vlahos, L. J.; Obradovic, A.; Laise, P.; Worley, J.; Tan, X.; Wang, A.-L.; Califano, A.

10.1101/2021.05.20.445002 — systems biology — Posted on 2022-01-25

806 Multigenerational exposure to heat stress induces phenotypic resilience, and genetic and epigenetic variations in Arabidopsis thaliana offspring

Yadav, N. S.; Titov, V.; Ayemere, I.; Byeon, B.; Ilnytskyy, Y.; Kovalchuk, I.

10.1101/2020.11.30.405365 — plant biology — Posted on 2022-01-25

807 UbE3-APA: A Bioinformatic Strategy to Elucidate Ubiquitin E3 Ligase Activities in Quantitative Proteomics Study

Gong, Y.; Chen, Y.

10.1101/2022.01.16.476541 — bioinformatics — Posted on 2022-01-25

808 Scaling effects of temperature on parasitism from individuals to host-parasite systems

Kirk, D.; O'Connor, M. I.; Mordecai, E. A.

10.1101/2020.12.01.406884 — ecology — Posted on 2022-01-25

809 Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to cell-cell adhesion through enhancing tight junctions

Kinoshita, N.; Yamamoto, T. S.; Yasue, N.; Takagi, C.; Fujimori, T.; Ueno, N.

10.1101/2020.10.04.323436 — cell biology — Posted on 2022-01-25

810 A unified view of low complexity regions (LCRs) across species

Lee, B.; Jaberi-Lashkari, N.; Calo, E.

10.1101/2022.01.06.475253 — cell biology — Posted on 2022-01-25

811 Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in Caenorhabditis elegans

Pena-Ramos, O.; Chiao, L.; Liu, X.; Yu, X.; Yao, T.; He, H.; Zhou, Z.

10.1101/2021.07.16.452694 — cell biology — Posted on 2022-01-25

812 Recurrent urinary tract infection and estrogen shape the taxonomic ecology and functional potential of the postmenopausal urobiome

Neugent, M. L.; Kumar, A.; Hulyalkar, N. V.; Lutz, K. C.; Nguyen, V. H.; Fuentes, J. L.; Zhang, C.; Nguyen, A.; Sharon, B. M.; Kuprasertkul, A.; Arute, A. P.; Ebrahimzadeh, T.; Natesan, N. J.; Li, Q.; Xing, C.; Shulaev, V.; Zimmern, P. E.; Palmer, K. L.; De Nisco, N. J.

10.1101/2021.11.06.467345 — microbiology — Posted on 2022-01-25

813 Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish

Bradshaw, W. J.; Poeschla, M.; Placzek, A.; Kean, S.; Valenzano, D. R.

10.1101/2020.08.21.261248 — immunology — Posted on 2022-01-25

814 Aβ/APP-induced hyperexcitability and dysregulation of homeostatic synaptic plasticity in models of Alzheimer's disease

Martinsson, I.; Quintino, L.; Garcia, M. G.; Konings, S. C.; Torres-Garcia, L.; Svanbergson, A.; Stange, O.; England, R.; Deierborg, T.; Li, J.-Y.; Lundberg, C.; Gouras, G. K.

10.1101/2022.01.25.477711 — neuroscience — Posted on 2022-01-25

815 Orphan nuclear receptors Err2 and 3 promote a feature-specific terminal differentiationprogram underlying gamma motor neuron function and proprioceptive movement control

Khan, M. N.; Cherukuri, P.; Negro, F.; Rajput, A.; Fabrowski, P.; Bansal, V.; Lancelin, C.; Lee, T.-I.; Bian, Y.; Mayer, W. P.; Akay, T.; Mueller, D.; Bonn, S.; Farina, D.; Marquardt, T.

10.1101/2022.01.25.477566 — neuroscience — Posted on 2022-01-25

816 Human cortical areas are sparsely connected: Combining histology with diffusion MRI to estimate the absolute number of axons

Rosen, B. Q.; Halgren, E.

10.1101/2021.06.07.447453 — neuroscience — Posted on 2022-01-25

817 The geometry of hippocampal CA2 representations enables abstract coding of social familiarity and identity

Boyle, L. M.; Posani, L.; Irfan, S.; Siegelbaum, S. A.; Fusi, S.

10.1101/2022.01.24.477361 — neuroscience — Posted on 2022-01-25

818 Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Lustberg, D. J.; Liu, J. Q.; Iannitelli, A. F.; Vanderhoof, S. O.; Liles, L. C.; McCann, K. E.; Weinshenker, D.

10.1101/2022.01.25.477573 — neuroscience — Posted on 2022-01-25

819 Schema representations in distinct brain networks support narrative memory during encoding and retrieval

Masis-Obando, R.; Norman, K. A.; Baldassano, C.

10.1101/2021.05.17.444363 — neuroscience — Posted on 2022-01-25

820 Modular and distinct PlexinA4/Farp2/Rac1 signaling controls dendrite morphogenesis

Danelon, V.; Goldner, R.; Martinez, E.; Gokhman, I.; Wang, K.; Yaron, A.; Tran, T. S.

10.1101/2020.01.15.908434 — neuroscience — Posted on 2022-01-25

821 Disrupted choline clearance and sustained acetylcholine release in vivo by a common choline transporter coding variant associated with poor attentional control in humans

Donovan, E.; Avila, C.; Klausner, S.; Parikh, V.; Fenollar-Ferrer, C.; Blakely, R. D.; Sarter, M.

10.1101/2021.06.27.450076 — neuroscience — Posted on 2022-01-25

822 Correction of the scientific production: publisher performance evaluation using a dataset of 4844 PubMed retractions.

Toma, C. S.; Padureanu, L.; Toma, B.

10.1101/2022.01.23.477400 — scientific communication and education — Posted on 2022-01-25

823 Strain and rupture of HIV-1 capsids during uncoating

Yu, A.; Lee, E. M. Y.; Briggs, J. A. G.; Ganser-Pornillos, B. K.; Pornillos, O.; Voth, G. A.

10.1101/2021.09.30.462583 — biophysics — Posted on 2022-01-25

824 Isotopic signatures induced by upwelling reveal regional fish populations in Lake Tanganyika

Ehrenfels, B.; Junker, J.; Namutebi, D.; Callbeck, C. M.; Dinkel, C.; Kalangali, A.; Kimirei, I. A.; Mbonde, A. S.; Mosille, J. B.; Sweke, E. A.; Schubert, C. J.; Seehausen, O.; Wagner, C. E.; Wehrli, B.

10.1101/2021.10.05.463178 — ecology — Posted on 2022-01-25

825 Biomolecular Tau condensation is linked to Tau accumulation at the nuclear envelope

Wegmann, S.; Hochmair, J.; Exner, C.; Franck, M.; Dominguez-Baquero, A.; Diez, L.; Brognaro, H.; Kraushar, M.; Mielke, T.; Radbruch, H.; Kaniyappan, S.; Falke, S.; Mandelkow, E.; Betzel, C.

10.1101/2022.01.24.477544 — molecular biology — Posted on 2022-01-25

826 Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype

O'Shea, T. M.; Ao, Y.; Wang, S.; Wollenberg, A. L.; Kim, J. H.; Ramos Espinoza, R. A.; Czechanski, A.; Reinholdt, L. G.; Deming, T. J.; Sofroniew, M. V.

10.1101/2022.01.24.477530 — neuroscience — Posted on 2022-01-25

827 MX2 viral substrate breadth and inhibitory activity are regulated by protein phosphorylation

Betancor, G.; Bangham, M. E. M.; Jeon, J. K.; Sha, K.; Lynham, S.; Jimenez Guardeno, J. M.; Malim, M. H.

10.1101/2022.01.24.477574 — microbiology — Posted on 2022-01-25

828 Reduced inflammatory response and promoted multiciliated cell differentiation in mice protected by defective interfering influenza virus

Wang, C.; Honce, R.; Salvatore, M.; Yang, J.; Twells, N. M.; Mahal, L. K.; Schultz-Cherry, S.; Ghedin, E.

10.1101/2022.01.25.477719 — microbiology — Posted on 2022-01-25

829 Human NLRP1 is activated by ZAKa-driven ribotoxic stress response

ROBINSON, K. S.; TOH, G. A.; ROZARIO, P.; BAYAT, S.; SUN, Z.; BAUERNFRIED, S.; NADKARNI, R.; HARAPAS, C. R.; LIM, C. K.; CHU, W.; TAN, K. Y.; BONNARD, C.; SOBOTA, R.; CONNOLLY, J. E.; MASTERS, S. L.; CHEN, K. W.; HO, L.; HORNUNG, V.; Zhong, F. L.

10.1101/2022.01.24.477516 — immunology — Posted on 2022-01-25

830 Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination With Nivolumab

Thudium, K.; Selby, M.; Zorn, J. A.; Rak, G.; Wang, X.-T.; Bunch, R. T.; Hogan, J. M.; Strop, P.; Korman, A. J.

10.1101/2022.01.24.477551 — cancer biology — Posted on 2022-01-25

831 MiR-1253 Potentiates Cisplatin Response in Pediatric Group 3 Medulloblastoma by Regulating Ferroptosis

Kanchan, R. K.; Perumal, N.; Khan, P.; Doss, D.; Chirravuri Venkata, R.; Thapa, I.; Vengoji, R.; Kaushal, J.; Siddiqui, J. A.; Nasser, M. W.; Batra, S. K.; Mahapatra, S.

10.1101/2022.01.24.477587 — cancer biology — Posted on 2022-01-25

832 Observing noncovalent interactions in experimental electron density for macromolecular systems: A novel perspective for protein-ligand interaction research

Ding, K.; Yin, S.; Li, Z.; Jiang, S.; Yang, Y.; Zhou, W.; Huang, B.; Zhang, Y.

10.1101/2022.01.24.468575 — biochemistry — Posted on 2022-01-25

833 Potentially prebiotic synthesis of aminoacyl-RNA via a bridging phosphoramidate-ester intermediate

Roberts, S. J.; Liu, Z.; Sutherland, J. D.

10.1101/2022.01.25.477680 — biochemistry — Posted on 2022-01-25

834 Functional and structural deficiencies of Gemin5 variants associated with neurological disease

Francisco-Velilla, R.; Embarc-Buh, A.; del Cano-Ochoa, F.; Abellan, S.; Vilar, M.; Alvarez, S.; Fernandez-Jaen, A.; Kour, S.; Rajan, D.; Pandey, U. B.; Ramon-Maiques, S.; Martinez-Salas, E.

10.1101/2022.01.25.477707 — molecular biology — Posted on 2022-01-25

835 Transcriptional, post-transcriptional, and post-translational mechanisms rewrite the tubulin code during cardiac hypertrophy and failure

Phyo, S. A.; Uchida, K.; Chen, C. Y.; Caporizzo, M. A.; Bedi, K.; Griffin, J.; Margulies, K.; Prosser, B. L.

10.1101/2022.01.24.477567 — molecular biology — Posted on 2022-01-25

836 HNRNPK is retained in the cytoplasm by Keratin 19 to stabilize target mRNAs

Fallatah, A.; Anastasakis, D.; Manzour, A.; Sharma, P.; Wang, X.; Jacob, A.; Elgerbi, A.; Alsharif, S.; Coulombe, P.; Hafner, M.; Chung, B. M.

10.1101/2022.01.24.477557 — molecular biology — Posted on 2022-01-25

837 Mouse Nuclear RNAi-defective 2 Promotes Splicing of Weak 5' Splice Sites

Flemr, M.; Schwaiger, M.; Hess, D.; Iesmantavicius, V.; Tuck, A. C.; Mohn, F.; Buehler, M.

10.1101/2022.01.25.477700 — molecular biology — Posted on 2022-01-25

838 An efficient CRISPR-Cas9 enrichment sequencing strategy for characterizing complex and highly duplicated genomic regions. A case study in the Prunus salicina LG3-MYB10 genes cluster.

Fiol, A.; Jurado-Ruiz, F.; Lopez-Girona, E.; Aranzana, M. J.

10.1101/2022.01.24.477518 — molecular biology — Posted on 2022-01-25

839 Human sialomucin CD164 is an essential entry factor for lymphocytic choriomeningitis virus

Liu, J.; Knopp, K. A.; Rackaityte, E.; Wang, C. Y.; Laurie, M. T.; Sunshine, S.; Puschnik, A. S.; DeRisi, J.

10.1101/2022.01.24.477570 — microbiology — Posted on 2022-01-25

840 Exit from lag phase in populations of Pseudomonas fluorescens is determined by strong interactions among cells

Ardre, M. B. P.; Doulcier, G.; Brenner, N.; Rainey, P. B.

10.1101/2022.01.24.477561 — microbiology — Posted on 2022-01-25

841 Metabolic strategies shared by basement residents of the Lost City hydrothermal field

Brazelton, W. J.; McGonigle, J. M.; Motamedi, S.; Pendleton, H. L.; Twing, K. I.; Miller, B. C.; Lowe, W. J.; Hoffman, A. M.; Prator, C. A.; Chadwick, G. L.; Anderson, R. E.; Thomas, E.; Butterfield, D. A.; Aquino, K. A.; Früh-Green, G. L.; Schrenk, M. O.; Lang, S. Q.

10.1101/2022.01.25.477282 — microbiology — Posted on 2022-01-25

842 Live biotherapeutic throat spray for respiratory virus inhibition and interferon pathway induction

Spacova, I.; De Boeck, I.; Cauwenberghs, E.; Delanghe, L.; Bron, P. A.; Henkens, T.; Simons, A.; Gamgami, I.; Persoons, L.; Claes, I.; van den Broek, M. F. L.; Schols, D.; Delputte, P.; Coenen, S.; Verhoeven, V.; Lebeer, S.

10.1101/2022.01.25.477549 — microbiology — Posted on 2022-01-25

843 Biogenic methane cycling is controlled by microbial cohorts

Mondav, R.; Martin, G.; Peura, S.; Garcia, S. L.

10.1101/2022.01.24.477581 — microbiology — Posted on 2022-01-25

844 P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

Jenster, L.-M.; Lange, K.-E.; Normann, S.; vom Hemdt, A.; Wuerth, J. D.; Schiffelers, L. D. J.; Tesfamariam, Y. M.; Gohr, F. N.; Klein, L.; Kaltheuner, I. H.; Lapp, D. J.; Mayer, J.; Moecking, J.; Ploegh, H. L.; Latz, E.; Geyer, M.; Kuemmerer, B. M.; Schmidt, F. I.

10.1101/2022.01.24.477423 — immunology — Posted on 2022-01-25

845 Two AGO proteins with transposon-derived sRNA cargo mark the germline in Arabidopsis

Bradamante, G.; Nguyen, V. H.; Incarbone, M.; Meir, Z.; Bente, H.; Dona, M.; Lettner, N.; Mittelsten Scheid, O.; Gutzat, R.

10.1101/2022.01.25.477718 — plant biology — Posted on 2022-01-25

846 Structural insight into antibody evasion of SARS-CoV-2 omicron variant

Verma, J.; Subbarao, N.

10.1101/2022.01.25.477671 — bioinformatics — Posted on 2022-01-25

847 Binding of Human ACE2 and RBD of Omicron Enhanced by Unique Interaction Patterns Among SARS-CoV-2 Variants of Concern

Kim, S.; Liu, Y.; Ziarnik, M.; Cao, Y.; Zhang, X. F.; Im, W.

10.1101/2022.01.24.477633 — biophysics — Posted on 2022-01-25

848 Structural Ramifications of Spike Protein D614G Mutation in SARS-CoV-2

Dokainish, H. M.; Sugita, Y.

10.1101/2022.01.24.477651 — biophysics — Posted on 2022-01-25

849 The Existence of At Least Three Genomic Signature Patterns and At Least Seven Subtypes of COVID-19 and the End of the Disease

Zhang, Z.

10.1101/2022.01.24.477579 — bioinformatics — Posted on 2022-01-25

850 Converting non-neutralizing SARS-CoV-2 antibodies targeting conserved epitopes into broad-spectrum inhibitors through receptor blockade

Weidenbacher, P. A.-B.; Waltari, E.; de los Rios Kobara, I.; Bell, B. N.; Pak, J. E.; Kim, P. S.

10.1101/2022.01.24.477625 — biochemistry — Posted on 2022-01-25

851 Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program

Wendt, F. R.; Pathak, G. A.; Vahey, J.; Qin, X.; Koller, D.; Cabrera-Mendoza, B.; Haeny, A.; Harrington, K. M.; Rajeevan, N.; Duong, L. M.; Levey, D. F.; De Angelis, F.; De Lillo, A.; Bigdeli, T. B.; Pyarajan, S.; VA Million Veteran Program, ; Gaziano, J. M.; Gelernter, J.; Aslan, M.; Provenzale, D.; Helmer, D. A.; Hauser, E. R.; Polimanti, R.; Department of Veteran Affairs Cooperative Study Program (#2006),

10.1101/2022.01.24.477583 — genomics — Posted on 2022-01-25

852 Pleiotropic enhancers are ubiquitous regulatory elements in the human genome

Laiker, I.; Frankel, N.

10.1101/2022.01.25.477532 — genomics — Posted on 2022-01-25

853 Ecosystem gross primary productivity after autumn snowfall and melt events in a mountain meadow

Stoy, P.; Khan, A. M.; Van Dorsten, K. M.; Sauer, P.; Weaver, T.; Brookshire, E. N. J.

10.1101/2022.01.25.477606 — ecology — Posted on 2022-01-25

854 Emergence of glycogen synthase kinase-3 interaction domain enhances phosphorylation of SARS-CoV-2 nucleocapsid protein

Yun, J. S.; Kim, N. H.; Song, H.; Cha, S. Y.; Hwang, K. H.; Lee, J. E.; Jeong, C.-H.; Song, S. H.; Kim, S.; Cho, E. S.; Kim, H. S.; Yook, J. I.

10.1101/2022.01.24.477037 — cell biology — Posted on 2022-01-25

855 The effect of COVID-19 mRNA vaccine on respiratory system: human lung carcinoma cells by means of Raman spectroscopy and imaging.

Abramczyk, H.; Surmacki, J. M.

10.1101/2022.01.24.477476 — cell biology — Posted on 2022-01-25

856 PPMO-mediated exon skipping induces uniform sarcolemmal dystrophin rescue with dose-dependent restoration of circulating microRNA biomarkers and muscle biophysical properties

Chwalenia, K.; Oieni, J.; Zemła, J.; Lekka, M.; Ahlskog, N.; Coenen-Stass, A. M. L.; McClorey, G.; Wood, M. J. A.; Lomonosova, Y.; Roberts, T. C.

10.1101/2022.01.25.477672 — molecular biology — Posted on 2022-01-25

857 Non-uniform dystrophin re-expression after CRISPR-mediated exon excision in the dystrophin/utrophin double-knockout mouse model of DMD

Hanson, B.; Stenler, S.; Ahlskog, N.; Chwalenia, K.; Svrzikapa, N.; Coenen-Stass, A. M. L.; Weinberg, M. S.; Wood, M. J. A.; Roberts, T. C.

10.1101/2022.01.25.477678 — molecular biology — Posted on 2022-01-25

858 The tyrosine phosphatase PRL regulates attachment of Toxoplasma gondii to host cells and is essential for virulence

Yang, C.; Blakely, W. J.; Arrizabalaga, G.

10.1101/2022.01.24.477641 — microbiology — Posted on 2022-01-25

859 Norepinephrine and dopamine contribute to distinct repetitive behaviors induced by novel odorant stress in male and female mice

Lustberg, D. J.; Liu, J. Q.; Iannitelli, A. F.; Vanderhoof, S. O.; Liles, L. C.; McCann, K. E.; Weinshenker, D.

10.1101/2022.01.25.477573 — neuroscience — Posted on 2022-01-25

860 Prior exposure to speech rapidly modulates cortical processing of high-level linguistic structure

Meng, Q.; Li Hegner, Y.; Giblin, I.; McMahon, C.; Johnson, B. W.

10.1101/2022.01.25.477669 — neuroscience — Posted on 2022-01-25

861 The rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2

Domingo-Muelas, A.; Morante-Redolat, J. M.; Moncho-Amor, V.; Jordan, A.; Perez-Villalba, A.; Carrillo-Barbera, P.; Belenguer, G.; Porlan, E.; Kirstein, M.; Bachs, O.; Ferron, S. R.; Lovell-Badge, R.; Farinas, I.

10.1101/2022.01.25.477676 — neuroscience — Posted on 2022-01-25

862 Impacts of development and adult sex on brain cell numbers in the Black Soldier Fly, Hermetia illucens L. (Diptera: Stratiomyidae)

Barrett, M.; Godfrey, R. K.; Sterner, E. J.; Waddell, E. A.

10.1101/2022.01.25.477588 — neuroscience — Posted on 2022-01-25

863 Inference and Uncertainty Quantification of Stochastic Gene Expression via Synthetic Models

Ocal, K.; Gutmann, M. U.; Sanguinetti, G.; Grima, R.

10.1101/2022.01.25.477666 — systems biology — Posted on 2022-01-25

864 LPS-TLR4 pathway stimulating in acute-on-chronic liver failure by promote NETs formation

Liu, Y.; Chen, S.; Wang, J.; Yu, S.; Zhang, X.; Li, Y.; Cao, G.

10.1101/2022.01.25.477506 — pathology — Posted on 2022-01-25

865 Exploring repeats in rice genomes: Identification, Characterization and its Applications

Das, G.; Ghosh, I.

10.1101/2022.01.24.477639 — bioinformatics — Posted on 2022-01-25

866 The chromosome-scale genome assembly of Jasminum sambac var. unifoliatum provide insights into the formation of floral fragrance

Zhou, C.; Zhu, C.; Tian, C.; Xie, S.; Xu, K.; Huang, L.; Wen, S.; Zhang, C.; Lai, Z.; Lin, Y.; Guo, Y.

10.1101/2022.01.25.477387 — genomics — Posted on 2022-01-25

867 Historical records of plant-insect interactions in subarctic Finland

Zoller, L.; Knight, T.

10.1101/2022.01.25.477384 — ecology — Posted on 2022-01-25

868 L-threonine mediated DAF-16/HSF-1 activation inhibits ferroptosis and increases healthspan

Kim, J.; Jo, Y.; Cho, D.; Ryu, D.

10.1101/2022.01.24.477604 — cell biology — Posted on 2022-01-25

869 Nonsynonymous mutations in fepR are associated with Listeria adaptation to low concentrations of benzalkonium chloride, but not increased survival in use level concentrations of benzalkonium chloride.

Bolten, S. J.; Harrand, S.; Skeens, J.; Wiedmann, M.

10.1101/2022.01.24.477644 — microbiology — Posted on 2022-01-25

870 Choice of 16S ribosomal RNA primers impacts urinary microbiota profiling

Heidrich, V.; Inoue, L. T.; Asprino, P. F.; Bettoni, F.; Mariotti, A. C. H.; Bastos, D. A.; Jardim, D. L. F.; Arap, M. A.; Camargo, A. A.

10.1101/2022.01.24.477608 — microbiology — Posted on 2022-01-25

871 Computationally efficient assembly of a Pseudomonas aeruginosa gene expression compendium

Doing, G.; Lee, A. J.; Neff, S. L.; Holt, J. D.; Stanton, B. A.; Greene, C. S.; Hogan, D. A.

10.1101/2022.01.24.477642 — microbiology — Posted on 2022-01-25

872 Characterization and identification of a novel daidzein reductase involved in (S)-equol biosynthesis in Clostridium C1

Hu, Y.-F.; Yang, C.-F.; Song, C.; Zhong, W.-X.; Li, B.; Cao, L.; Chen, H.; Zhao, C.-H.; Yin, Y.

10.1101/2022.01.24.477643 — microbiology — Posted on 2022-01-25

873 Biodiversity of the Genus Trichoderma in the Rhizosphere of Coffee (Coffea arabica) Plants in Ethiopia and their Potential Use in Biocontrol of Coffee Wilt Disease

Mulatu, A.; Megersa, N.; Abena, T.; Kanagarajan, S.; Liu, Q.; Alemu, T.; Vetukuri, R. R.

10.1101/2022.01.24.477504 — microbiology — Posted on 2022-01-25

874 Towards the identification and optimization of the "dose-response" relationship of transcranial direct current stimulation

Salvador, R.; Biagi, M. C.; Perez Pelegri, M.; Zhou, J.; Travison, T.; Alvaro Pascual-Leone, A.; Manor, B.; Ruffini, G.

10.1101/2022.01.22.477353 — neuroscience — Posted on 2022-01-25

875 Visual uncertainty unveils the distinct role of haptic cues in multisensory grasping

Camponogara, I.; Volcic, R.

10.1101/2022.01.25.477675 — neuroscience — Posted on 2022-01-25

876 Xtrapol8: automatic elucidation of low-occupancy intermediate-states in crystallographic studies

De Zitter, E.; Coquelle, N.; Barends, T. R. M.; Colletier, J.-P.

10.1101/2022.01.09.475568 — biophysics — Posted on 2022-01-25

877 Template-based design of peptides to inhibit SARS-CoV-2 RNA-dependent RNA polymerase complexation.

Chenna, A.; Khan, W. H.; Dash, R.; Rathore, A. S.; Goel, G.

10.1101/2022.01.24.477502 — bioinformatics — Posted on 2022-01-25

Smith, I.; Haibe-Kains, B.

10.1101/2022.01.24.477615 — bioinformatics — Posted on 2022-01-25

879 Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail

Addetia, A.; Park, Y.-J.; Starr, T.; Greaney, A. J.; Sprouse, K.; Bowen, J. E.; Tiles, S. W.; Van Voorhis, W. C.; Bloom, J. D.; Corti, D.; Walls, A. C.; Veesler, D.

10.1101/2022.01.21.477288 — biochemistry — Posted on 2022-01-25

880 Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

Yang, X.; Dickmander, R. J.; Bayati, A.; Taft-Benz, S. A.; Smith, J. L.; Madden, E. A.; Brown, J. W.; Lenarcic, E. M.; Yount, B. L.; Chang, E.; Axtman, A. D.; Baric, R. S.; Heise, M. T.; McPherson, P. S.; Moorman, N. J.; Willson, T. M.

10.1101/2022.01.03.474779 — cell biology — Posted on 2022-01-25

881 Substantial immune response in Omicron infected breakthrough and unvaccinated individuals against SARS-CoV-2 variants of concerns

Yadav, P. D.; Sapkal, G.; Sahay, R. R.; Potdar, V.; Deshpande, G.; Patil, D. Y.; Nyayanit, D. A.; Shete, A. M.; Shastri, J.; Awate, P.; Malhotra, B.; Abraham, P.

10.1101/2022.01.24.477043 — microbiology — Posted on 2022-01-25

882 SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-weeks interval between doses

Chatterjee, D.; Tauzin, A.; Marchitto, L.; Gong, S. Y.; Boutin, M.; Bourassa, C.; Beaudoin-Bussieres, G.; Bo, Y.; Ding, S.; Laumaea, A.; Vezina, D.; Perreault, J.; Gokool, L.; Morrisseau, C.; Arlotto, P.; Fournier, E.; Guilbault, A.; Delisle, B.; Levade, I.; Goyette, G.; Gendron-Lepage, G.; Medjahed, H.; De Serres, G.; Tremblay, C.; Martel-Laferriere, V.; Kaufmann, D. E.; Bazin, R.; Prevost, J.; Moreira, S.; Richard, J.; Cote, M.; Finzi, A.

10.1101/2021.12.21.473679 — microbiology — Posted on 2022-01-25

883 Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

Yan, H.; Wang, X.; Xiong, Q.; Cao, L.; Ma, C.; Liu, C.; Si, J.; Liu, P.; Gu, M.; Wang, C.; Shi, L.; Tong, F.; Huang, M.; Zhao, C.; Li, J.; Shen, C.; Chen, Y.; Zhao, H.; Lan, K.

10.1101/2022.01.24.477490 — microbiology — Posted on 2022-01-25

884 Mutations of SARS-CoV-2 variants of concern escaping Spike-specific T cells

Le Bert, N.; Tan, A. T.; Kunasegaran, K.; Chia, A.; Tan, N.; Chen, Q.; Hang, S. K.; Qui, M. D.; Chan, B. S.; Low, J. G.; Young, B.; Ng, K. C.; Chan, D. W. S.; Lye, D. C. B.; Bertoletti, A.

10.1101/2022.01.20.477163 — immunology — Posted on 2022-01-25

885 Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variants

Wang, E.; Chakraborty, A. K.

10.1101/2022.01.24.477469 — immunology — Posted on 2022-01-25

886 BrainStat: A toolbox for brain-wide statistics and neuroscientific contextualization

Vos de Wael, R.; Bayrak, S.; Benkarim, O.; Herholz, P.; Lariviere, S.; Rodriguez-Cruces, R.; Paquola, C.; Hong, S.-J.; Misic, B.; Evans, A.; Valk, S.; Bernhardt, B.

10.1101/2022.01.18.476795 — neuroscience — Posted on 2022-01-25

887 The scotopic band: primate detailed scotopic vision and perceptual uncertainty

Barash, S.; Spivak, O.; Thier, P.

10.1101/2022.01.25.477659 — neuroscience — Posted on 2022-01-25

888 Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

10.1101/2022.01.22.477323 — pharmacology and toxicology — Posted on 2022-01-25

889 No impact of biocontrol agent's predation cues on development time or size of surviving Aedes albopictus under optimal nutritional availability

Russell, M. C.; Cator, L. J.

10.1101/2021.09.16.460697 — ecology — Posted on 2022-01-25

890 Defects in DNA double-strand break repair re-sensitise antibiotic-resistant Escherichia coli tomultiple bactericidal antibiotics

Revitt-Mills, S. A.; Wright, E. K.; Vereker, M.; O'Flaherty, C.; McPherson, F.; Dawson, C.; van Oijen, A. M.; Robinson, A.

10.1101/2022.01.24.477632 — microbiology — Posted on 2022-01-25

891 Microbial habitability of the early Mars lacustrine environment sustained by iron redox cycling

Moore, R. A.; Carr, C. E.

10.1101/2021.09.07.459191 — microbiology — Posted on 2022-01-25

892 CHD8 regulates gut epithelial cell function and affects autism-related behaviours through the gut-brain axis

Chaterjee, I.; Getselter, D.; Ghaneem, N.; Bel, S.; Elliott, E.

10.1101/2021.10.02.462735 — neuroscience — Posted on 2022-01-25

893 SARS-CoV-2 entry sites are present in all structural elements of the human glossopharyngeal and vagal nerves: clinical implications

Vitale-Cross, L.; Szalayova, I.; Scoggins, A.; Palkovits, M.; Mezey, E.

10.1101/2021.12.30.474580 — neuroscience — Posted on 2022-01-25

894 Single cell sequencing reveals microglia induced angiogenesis by specific subsets of endothelial cells following spinal cord injury

Yao, C.; Cao, Y.; Lv, Y.; Wang, D.; Liu, Y.; Gu, X.; Wang, Y.; WANG, X.; Yu, B.

10.1101/2022.01.25.477640 — neuroscience — Posted on 2022-01-25

895 DisGUVery: a versatile open-source software for high-throughput image analysis of Giant Unilamellar Vesicles

van Buren, L.; Koenderink, G. H.; Martinez-Torres, C.

10.1101/2022.01.25.477663 — biophysics — Posted on 2022-01-25

896 High throughput RNA sequencing discovers symptomatic and latent viruses: an example from ornamental Hibiscus

Zhou, S.; Richert-Poeggeler, K.; Wang, Z.; Heslop-Harrison, J.; Liu, Q.

10.1101/2022.01.25.477650 — genomics — Posted on 2022-01-25

897 Types of cis- and trans-gene regulation of expression quantitative trait loci across human tissues

Kvammes, J.; Badsha, M. B.; Martin, E. A.; Wu, J.; Megheib, M.; Wang, X.; Fu, A. Q.

10.1101/2022.01.24.477617 — genomics — Posted on 2022-01-25

898 Decoding the IGF1 Signaling Gene Regulatory Network Behind Alveologenesis from A Mouse Model of Bronchopulmonary Dysplasia

Gao, F.; Li, C.; Smith, S.; Peinado, N.; Kohbodi, G.; Tran, E.; Loh, E.; Li, W.; Borok, Z.; Minoo, P.

10.1101/2022.01.24.477613 — developmental biology — Posted on 2022-01-25

899 Light-controlled phosphorylation in the TrkA-Y785 site by photosensitive UAAs activates the MAPK/ERK signaling pathway

Zhao, S.; Liu, D.

10.1101/2022.01.24.477628 — molecular biology — Posted on 2022-01-25

900 Environmental change alters nitrogen fixation rates and microbial parameters in a subarctic biological soil crust

Salazar, A.; Warshan, D.; Vasquez, C.; Andresson, O.

10.1101/2022.01.25.477655 — microbiology — Posted on 2022-01-25

901 DciA helicase operators exhibit diversity across bacterial phyla

Blaine, H. C.; Burke, J. T.; Ravi, J.; Stallings, C. L.

10.1101/2022.01.24.477630 — microbiology — Posted on 2022-01-25

902 The Temporal and Contextual Stability of Activity Levels in Hippocampal CA1 Cells

Hayashi, Y.; Kobayakawa, K.; Kobayakawa, R.

10.1101/2022.01.24.477445 — neuroscience — Posted on 2022-01-25

903 Two roles for choice selective inhibition in decision-making circuits

Roach, J. P.; Churchland, A. K.; Engel, T. A.

10.1101/2022.01.24.477635 — neuroscience — Posted on 2022-01-25

904 Impaired glutamate reuptake induces synaptic mistuning in rat hippocampal slices, that can be counteracted by ketamine

Vazquez-Juarez, E.; Srivastava, I.; Lindskog, M.

10.1101/2022.01.25.477658 — neuroscience — Posted on 2022-01-25

905 Theoretical Principles of Enhancer-Promoter Communication in Transcriptional Bursting

Wang, Z.; Zhang, Z.; Luo, S.; Zhou, T.; Zhang, J.

10.1101/2022.01.24.477520 — systems biology — Posted on 2022-01-25

906 Rhythm of The Night (and Day): Predictive metabolic modeling of circadian growth in Chlamydomonas

Metcalf, A. J.; Boyle, N.

10.1101/2022.01.24.477634 — systems biology — Posted on 2022-01-25

907 miniTurbo-based interactomics of two plasma membrane-localized SNARE proteins in Marchantia polymorpha

Melkonian, K.; Stolze, S. C.; Harzen, A.; Nakagami, H.

10.1101/2022.01.21.477208 — plant biology — Posted on 2022-01-25

908 Increased parasite load is associated with reduced metabolic rates and escape responsiveness in pumpkinseed sunfish host

Guitard, J. J.; Chretien, E.; De Bonville, J.; Roche, D. G.; Boisclair, D.; Binning, S. A.

10.1101/2022.01.24.477519 — physiology — Posted on 2022-01-25

909 The central clock suffices to drive the majority of circulatory metabolic rhythms

Petrus, P.; Smith, J. G.; Koronowski, K. B.; Chen, S.; Sato, T.; Greco, C. M.; Mortimer, T.; Welz, P.-S.; Zinna, V. M.; Shimaji, K.; Cervantes, M.; Baldi, P.; Canoves, P. M.; Sassone-Corsi, P.; Benitah, S. A.

10.1101/2022.01.24.477514 — physiology — Posted on 2022-01-25

910 E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer

Russo, G. C.; Crawford, A. J.; Clark, D. J.; Cui, J.; Carney, R.; Karl, M. N.; Su, B.; Starich, B. A.; Lih, T.-S.; Kamat, P.; Zhang, Q.; Wu, P.-h.; Lee, M.-H.; Leong, H. S.; Rebecca, V. W.; Zhang, H.; Wirtz, D.

10.1101/2020.11.04.368746 — cancer biology — Posted on 2022-01-25

911 Cannabidiol increases gramicidin current in human embryonic kidney cells: An observational study

Ghovanloo, M. R.; Goodchild, S. J.; Ruben, P.

10.1101/2022.01.24.477627 — biophysics — Posted on 2022-01-25

912 Dissecting Mutational Allosteric Effects in Alkaline Phosphatases Associated with Different Hypophosphatasia Phenotypes: An Integrative Computational Investigation

Xiao, F.; Zhou, Z.; Song, X.; Gan, M.; Long, J.; Verkhivker, G.; Hu, G.

10.1101/2022.01.24.477621 — biophysics — Posted on 2022-01-25

913 FMSClusterFinder: A new tool for detection and identification of clusters of sequential motifs with varying characteristics inside genomic sequences

Hejazi, M. M.; Golabi, F.; Bahrami, M.; Hejazi, M. S.

10.1101/2022.01.23.474238 — bioinformatics — Posted on 2022-01-25

914 Genomics-based annotations help unveil the molecular composition of edible plants

Ofaim, S.; Menichetti, G.; Sebek, M.; Barabasi, A. L.

10.1101/2022.01.24.477528 — bioinformatics — Posted on 2022-01-25

915 Self-rectifying magnetoelectric metamaterials enable precisely timed remote neural stimulation and restoration of sensory motor functions

Bhave, G.; Chen, J. C.; Alrashdan, F.; Robinson, J. T.

10.1101/2022.01.24.477527 — bioengineering — Posted on 2022-01-25

916 Transforming chemical proteomics enrichment into high throughput method using SP2E workflow.

Becker, T.; Wiest, A.; Telek, A.; Bejko, D.; Hoffmann-Roeder, A.; Kielkowski, P.

10.1101/2022.01.24.477214 — biochemistry — Posted on 2022-01-25

917 Genetic regulation of human aortic smooth muscle cell gene expression and splicing predict causal coronary artery disease genes

Aherrahrou, R.; Lue, D.; Perry, R. N.; Aberra, Y. T.; Khan, M. D.; Soh, J. Y.; Ord, T.; Singha, P.; Gilani, H.; Benavente, E. D.; Wong, D.; Hinkle, J.; Ma, L.; Sheynkman, G. M.; den Ruijter, H. H.; Miller, C. L.; Bjorkegren, J. L. M.; Kaikkonen, M. U.; Civelek, M.

10.1101/2022.01.24.477536 — genetics — Posted on 2022-01-25

918 Functional wetland loss drives emerging risks to waterbird migration networks

Donnelly, J. P.; Moore, J. N.; Casazza, M. L.; Coons, S. P.

10.1101/2022.01.24.477605 — ecology — Posted on 2022-01-25

919 "Holey" niche! Finding holes in niche hypervolumesusing persistence homology

Conceicao, P. V.; Morimoto, J.

10.1101/2022.01.21.477279 — ecology — Posted on 2022-01-25

920 Cullin-5 regulates nuclear positioning and reveals insights on the sensing of the nuclear-to-cytoplasmic ratio in Drosophila embryogenesis

Hayden, L.; Chao, A.; Deneke, V.; Puliafito, A.; Di Talia, S.

10.1101/2022.01.24.477546 — developmental biology — Posted on 2022-01-25

921 USH2A gene mutations in rabbits lead to progressive retinal degeneration and hearing loss

Nguyen, V. P.; Song, J.; Prieskorn, D.; Li, Y.; Dolan, D.; Xu, J.; Zhang, J.; Jayasundera,, K. T.; Raphael, Y.; Chen, E. Y.; Paulus, Y.; Yang, D.

10.1101/2022.01.24.476758 — developmental biology — Posted on 2022-01-25

922 A system-wide quantitative map of RNA and protein subcellular localisation dynamics

Villanueva, E.; Smith, T.; Pizzinga, M.; Elzek, M.; Queiroz, R. M. L.; Harvey, R. F.; Breckels, L. M.; Crook, O. M.; Monti, M.; Dezi, V.; Willis, A. E.; Lilley, K. S.

10.1101/2022.01.24.477541 — cell biology — Posted on 2022-01-25

923 Broad-Spectrum Antimicrobial Potential of Crassula ovata

Agbedanu, P. N.; Puga, T. B.; Schafer, J.; Buffalo, A.

10.1101/2022.01.20.477177 — microbiology — Posted on 2022-01-25

924 Fully Human Antibody Immunoglobulin from Transchromosomic Bovines is Potent Against SARS-CoV-2 Variant Pseudoviruses

Luke, T.; Wu, H.; Egland, K. A.; Sullivan, E. J.; Bausch, C. L.

10.1101/2021.08.09.454215 — immunology — Posted on 2022-01-25

925 A scalp geometry parameter-space for optimization and implementation of conventional TMS coil placement

Jiang, Y.; Du, B.; Chen, Y.; Wei, L.; Cao, Z.; Zhang, Z.; Xie, C.; Li, G.; Cai, Z.; Li, Z.; Zhu, C.

10.1101/2022.01.22.477370 — neuroscience — Posted on 2022-01-25

926 Hippocampal delta oscillations entrain neuronal activity, modulate gamma amplitude and convey information about running speed on a treadmill

Furtunato, A. M. B.; Pedrosa, R.; Lobao-Soares, B.; Tort, A. B. L.; Belchior, H. A.

10.1101/2022.01.24.477542 — neuroscience — Posted on 2022-01-25

927 A sparse set of spikes corresponding to reliable correlations is highly informative of visual stimulus on single trials

Levy, M.; Guo, J. K.; MacLean, J. N.

10.1101/2022.01.24.477564 — neuroscience — Posted on 2022-01-25

928 Multilevel Development of Cognitive Abilities in an Artificial Neural Network

Volzhenin, K.; Changeux, J.-P.; Dumas, G.

10.1101/2022.01.24.477526 — neuroscience — Posted on 2022-01-25

929 Hippocampal fear engrams modulate ethanol-induced maladaptive contextual generalization in mice.

Cincotta, C.; Ruesch, E.; Senne, R.; Ramirez, S.

10.1101/2022.01.24.477538 — neuroscience — Posted on 2022-01-25

930 Variability in sampling of cortex-wide neural dynamics explains individual differences in functional connectivity and behavioral phenotype

MacDowell, C. J.; Briones, B. A.; Lenzi, M. J.; Gustison, M. L.; Buschman, T. J.

10.1101/2022.01.24.477572 — neuroscience — Posted on 2022-01-25

931 The geometry of hippocampal CA2 representations enables abstract coding of social familiarity and identity

Boyle, L. M.; Posani, L.; Irfan, S.; Siegelbaum, S. A.; Fusi, S.

10.1101/2022.01.24.477361 — neuroscience — Posted on 2022-01-25

932 Post-embryonic maturation of the C. elegans motor circuit

Mulcahy, B.; Witvliet, D.; Mitchell, J. K.; Schalek, R.; Berger, D.; Wu, Y.; Holmyard, D.; Lu, Y.; Ahamed, T.; Samuel, A. D.; Chisholm, A. D.; Lichtman, J. W.; Zhen, M.

10.1101/2022.01.24.477421 — neuroscience — Posted on 2022-01-25

933 Wheat EARLY FLOWERING3 is a dawn-expressed circadian oscillator component that regulates heading date

Wittern, L.; Steed, G.; Taylor, L. J.; Greenland, A.; Gardner, K.; Hannah, M. A.; Webb, A. A. R.

10.1101/2021.09.03.458922 — plant biology — Posted on 2022-01-25

934 Interspecies transfer of syntenic RAMOSA1 orthologs and promoter cis sequences impacts maize inflorescence architecture

Strable, J.; Unger-Wallace, E.; Aragon-Raygoza, A.; Briggs, S.; Vollbrecht, E.

10.1101/2022.01.07.475427 — plant biology — Posted on 2022-01-25

935 Phase separation of tunable biomolecular condensates predicted by an interacting particle model

Munoz-Gil, G.; Romero, C.; Mateos, N.; de Llobet Cucalon, L. I.; Beato, M.; Lewenstein, M.; Garcia-Parajo, M. F.; Torreno-Pina, J. A.

10.1101/2020.09.09.289876 — biophysics — Posted on 2022-01-25

936 Septin-Mediated Mechanobiological Reprogramming of T Cell Transmigration and 3D Motility

Zhovmer, A. S.; Manning, A.; Smith, C.; Vishweshwaraiah, Y. L.; Wang, J.; Saez, P. J.; Ma, X.; Cartagena-Rivera, A. X.; Singh, R. K.; Dokholyan, N. V.; Tabdanov, E. D.

10.1101/2022.01.18.476840 — biophysics — Posted on 2022-01-25

937 Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

Autio, M. I.; Motakis, E.; Perrin, A.; Bin Amin, T.; Tiang, Z.; Do, D. V.; Wang, J.; Tan, J.; Tan, W. X.; Teo, A. K. K.; Foo, R.

10.1101/2021.12.07.471422 — bioengineering — Posted on 2022-01-25

938 The Blepharisma stoltei macronuclear genome: towards the origins of whole genome reorganization

Singh, M.; Seah, B. K. B.; Emmerich, C.; Singh, A.; Woehle, C.; Huettel, B.; Byerly, A.; Stover, N. A.; Sugiura, M.; Harumoto, T.; Swart, E. C.

10.1101/2021.12.14.471607 — genomics — Posted on 2022-01-25

939 Can double PPO mutations exist in the same allele and are such mutants functional?

Porri, A.; Machado Noguera, M.; Betz, M.; Saelinger, D.; Braendle, F.; Bowe, S.; Lerchl, J.; Meyer, L.; Knapp, M.; Roma-Burgos, N.

10.1101/2022.01.21.477186 — genetics — Posted on 2022-01-25

940 Mutualism-enhancing mutations dominate early adaptation in a microbial community

Venkataram, S.; Kuo, H.-Y.; Hom, E. F. Y.; Kryazhimskiy, S.

10.1101/2021.07.07.451547 — evolutionary biology — Posted on 2022-01-25

941 A within-host infection model to explore tolerance andresistance

Pierre, L.; Christine, L.; Parthuisot, N.; Faucher, C.; Duneau, D.; Ferdy, J.-B.

10.1101/2021.10.19.464998 — evolutionary biology — Posted on 2022-01-25

942 Stem girth changes in response to soil water potential in lowland dipterocarp forest in Borneo: a phenomenological and individualistic time-series analysis

Newbery, D. M.; Lingenfelder, M.

10.1101/2020.07.28.222547 — ecology — Posted on 2022-01-25

943 Mechano-signaling feedback underlies precise inner hair cell patterning in the organ of Corti

Cohen, R.; Taiber, S.; Loza, O.; Kasirer, S.; Woland, S.; Sprinzak, D.

10.1101/2022.01.24.477468 — developmental biology — Posted on 2022-01-25

944 MicroRNA-24-3p promotes skeletal muscle differentiation and regeneration by regulating HMGA1

Dey, P.; Soyer, M. A.; Dey, B. K.

10.1101/2020.11.10.371872 — developmental biology — Posted on 2022-01-25

945 MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1

La Spada, A.; Branch, M. R.; Hsu, C.; Ohnishi, K.; Lee, E.; Meisenhelder, J.; Winborn, B. J.; Sopher, B.; Taylor, J. P.; Hunter, T.

10.1101/2021.11.08.467702 — cell biology — Posted on 2022-01-25

946 Ligand-independent modulation of GIPR signaling by splice variants

Hang, K.; Shao, L.; Zhou, Q.; Zhao, F.; Dai, A.; Cai, X.; Stevens, R. C.; Yang, D.; Wang, M.-W.

10.1101/2022.01.24.477496 — molecular biology — Posted on 2022-01-25

947 Region-specific microRNA alterations in marmosets carrying SLC6A4 polymorphisms are associated with anxiety-like behavior.

Popa, N.; Bachar, D.; Roberts, A. C.; Santangelo, A. M.; Gascon, E.

10.1101/2021.04.08.437842 — neuroscience — Posted on 2022-01-25

948 Minian: An open-source miniscope analysis pipeline

Dong, Z.; Mau, W.; Feng, Y.; Pennington, Z. T.; Chen, L.; Zaki, Y.; Rajan, K.; Shuman, T.; Aharoni, D.; Cai, D. J.

10.1101/2021.05.03.442492 — neuroscience — Posted on 2022-01-25

949 biPACT: a method for three-dimensional visualization of mouse spinal cord circuits of long segments with high resolution

Nakanishi, K.; Shinozaki, M.; Nagoshi, N.; Nakamura, M.; Okano, H.

10.1101/2021.12.12.472305 — neuroscience — Posted on 2022-01-25

950 Connectome Spatial Smoothing (CSS): concepts, methods, and evaluation

Mansour L., S.; Seguin, C.; Smith, R. E.; Zalesky, A.

10.1101/2021.09.19.461011 — neuroscience — Posted on 2022-01-25

951 An in vitro neuronal model replicating the in vivo maturation and heterogeneity of perineuronal nets

Dickens, S.; Goodenough, A.; Kwok, J. C. F.

10.1101/2022.01.22.477344 — neuroscience — Posted on 2022-01-25

952 A learned map for places and concepts in the human MTL

Herweg, N. A.; Kunz, L.; Schonhaut, D. R.; Brandt, A.; Wanda, P. A.; Sharan, A. D.; Sperling, M. R.; Schulze-Bonhage, A.; Kahana, M. J.

10.1101/2020.06.15.152504 — neuroscience — Posted on 2022-01-25

953 Equivalent noise characterization of human lightness constancy

Singh, V.; Burge, J.; Brainard, D. H.

10.1101/2021.06.04.447171 — neuroscience — Posted on 2022-01-25

954 Ultrahigh-Throughput Ambient MS: Direct Analysis at 22 Samples per Second by Infrared Matrix-Assisted Desorption Electrospray Ionization Mass Spectrometry

Radosevich, A. J.; Pu, F.; Chang-Yen, D.; Sawicki, J. W.; Talaty, N. N.; Elsen, N. L.; Williams, J. D.; Pan, J. Y.

10.1101/2021.10.25.465730 — pharmacology and toxicology — Posted on 2022-01-25

955 Label-free imaging of collagen fibers in tissue slices using phase imaging with computational specificity

Sakakura, M.; Macias, V.; Borhani, S.; Kajdacsy-Balla, A.; Popescu, G.

10.1101/2021.11.19.469223 — pathology — Posted on 2022-01-25

956 Polyunsaturated fatty acid structure determines the strength of potentiation of Acid-sensing ion channels

Klipp, R. C.; Bankston, J. R.

10.1101/2021.06.25.449979 — biophysics — Posted on 2022-01-25

957 RUV-III-NB: Normalization of single cell RNA-seq Data

Salim, A.; Molania, R.; Wang, J.; De Livera, A.; Thijssen, R.; Speed, T. P.

10.1101/2021.11.06.467575 — bioinformatics — Posted on 2022-01-25

958 Sift-PULs: A public repository for specific functional polysaccharide utilization loci

Song, T.; Wei, C.; Yuan, D.; Xiang, S.; Liu, L.; Lv, H.; Wang, B.; Huang, T.; Zhao, K.; Wang, X.; Chu, Y.; Luo, D.; Lin, J.

10.1101/2021.08.04.455021 — bioinformatics — Posted on 2022-01-25

959 UbE3-APA: A Bioinformatic Strategy to Elucidate Ubiquitin E3 Ligase Activities in Quantitative Proteomics Study

Gong, Y.; Chen, Y.

10.1101/2022.01.16.476541 — bioinformatics — Posted on 2022-01-25

960 Computation of the mitochondrial age distribution along the axon length

Kuznetsov, I. A.; Kuznetsov, A. V.

10.1101/2021.09.12.459928 — bioengineering — Posted on 2022-01-25

961 Social integration predicts survival in female white-faced capuchin monkeys

KAJOKAITE, K.; Whalen, A.; Koster, J.; Perry, S.

10.1101/2020.08.04.235788 — animal behavior and cognition — Posted on 2022-01-25

962 Transcriptional mapping of the macaque retina and RPE-choroid reveals conserved inter-tissue transcription drivers and signaling pathways

Mungales, A.; McGaughey, D.; Zhang, C.; Yousaf, S.; Liu, J.; Brooks, B.; Maminishkis, A.; Fufa, T.; Hufnagel, R.

10.1101/2022.01.21.477280 — genomics — Posted on 2022-01-25

963 Impact of genomic preselection on subsequent genetic evaluations with ssGBLUP - using real data from pigs

Jibrila, I.; Vandenplas, J.; ten Napel, J.; Bergsma, R.; Veerkamp, R. F.; Calus, M. P. L.

10.1101/2021.06.18.449002 — genetics — Posted on 2022-01-25

964 Genetic mechanisms for tissue-specific essential genes

Dvir, E.; Shohat, S.; Shifman, S.

10.1101/2021.04.09.438977 — genetics — Posted on 2022-01-25

965 TreeSearch: morphological phylogenetic analysis in R

Smith, M. R.

10.1101/2021.11.08.467735 — evolutionary biology — Posted on 2022-01-25

966 The effects of weak selection on neutral diversity at linked sites

Charlesworth, B.

10.1101/2021.11.27.470208 — evolutionary biology — Posted on 2022-01-25

967 Automated Landmarking via Multiple Templates

Zhang, C.; Porto, A.; Rolfe, S.; Kocatulum, A.; Maga, A. M.

10.1101/2022.01.04.474967 — evolutionary biology — Posted on 2022-01-25

968 A chromosomal inversion may facilitate adaptation despite periodic gene flow in a freshwater fish

Thorstensen, M. J.; Euclide, P. T.; Jeffrey, J. D.; Shi, Y.; Treberg, J. R.; Watkinson, D. A.; Enders, E. C.; Larson, W. A.; Kobayashi, Y.; Jeffries, K.

10.1101/2021.12.02.470985 — evolutionary biology — Posted on 2022-01-25

969 How to describe and measure phenology? An investigation on the diversity of metrics using phenology of births in large herbivores

Thel, L.; Chamaille-Jammes, S.; Bonenfant, C.

10.1101/2021.05.17.444418 — ecology — Posted on 2022-01-25

970 Manipulating the microbiome alters regenerative outcomes in Xenopus laevis tadpoles via lipopolysaccharide signalling

Chapman, P. A.; Gilbert, C. B.; Devine, T. J.; Hudson, D. T.; Ward, J.; Morgan, X. C.; Beck, C. W.

10.1101/2021.12.09.472019 — developmental biology — Posted on 2022-01-25

971 Fingerprinting of skin cells by live cell Raman spectroscopy reveals melanoma cell heterogeneity and cell-type specific responses to UVR

Mort, R.; Wilkinson, E.; Allinson, S.; Kerns, J. G.; Ashton, L.

10.1101/2021.11.12.468396 — cell biology — Posted on 2022-01-25

972 A surface morphometrics toolkit to quantify organellar membrane ultrastructure using cryo-electron tomography

Barad, B. A.; Medina, M.; Fuentes, D.; Wiseman, R. L.; Grotjahn, D. A.

10.1101/2022.01.23.477440 — cell biology — Posted on 2022-01-25

973 Spatial regulation of the anaphase-promoting complex/cyclosome by a microtubule adaptor

Cao, X.; Shami Shah, A.; Sanford, E. J.; Smolka, M. B.; Baskin, J. M.

10.1101/2022.01.04.474939 — cell biology — Posted on 2022-01-25

974 Trypanosomal variant surface glycoprotein expression in human African trypanosomiasis patients

So, J.; Sudlow, S.; Sayeed, A.; Grudda, T.; Deborggraeve, S.; Ngoyi, D. M.; Desamber, D. K.; Wickstead, B.; Lejon, V.; Mugnier, M. R.

10.1101/2021.09.09.459620 — microbiology — Posted on 2022-01-25

975 Dramatic consequences of reducing erythrocyte membrane cholesterol on Plasmodium falciparum

Ahiya, A. I.; Bhatnagar, S.; Morrisey, J. M.; Beck, J. R.; Vaidya, A. B.

10.1101/2021.10.06.463412 — microbiology — Posted on 2022-01-25

976 Combination of high pressure treatment at 500 MPa and biopreservation with a Lactococcus lactis strain for lowering the bacterial growth during storage of diced cooked ham with reduced nitrite salt

Chaillou, S.; Ramaroson, M.; Coeuret, G.; Rossero, A.; Anthoine, V.; Champomier-Verges, M.; Moriceau, N.; Reze, S.; Martin, J.-L.; Guillou, S.; Zagorec, M.

10.1101/2020.07.22.215863 — microbiology — Posted on 2022-01-25

977 Hierarchical decoupling of electromagnetic and haemodynamic cortical networks

Shafiei, G.; Baillet, S.; Misic, B.

10.1101/2021.09.07.458941 — neuroscience — Posted on 2022-01-25

978 A deep learning framework for inference of single-trial neural population activity from calcium imaging with sub-frame temporal resolution

Zhu, F.; Grier, H. A.; Tandon, R.; Cai, C.; Giovannucci, A.; Kaufman, M. T.; Pandarinath, C.

10.1101/2021.11.21.469441 — neuroscience — Posted on 2022-01-25

979 Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice

Lisgaras, C. P.; Scharfman, H. E.

10.1101/2021.06.28.450253 — neuroscience — Posted on 2022-01-25

980 FiberNeat: Unsupervised White Matter Tract Filtering

Chandio, B. Q.; Chattopadhyay, T.; Owens-Walton, C.; Villalon Reina, J. E.; Nabulsi, L.; Thomopoulos, S. I.; Garyfallidis, E.; Thompson, P. M.

10.1101/2021.10.26.465991 — neuroscience — Posted on 2022-01-25

981 PyRodentTracks: flexible computer vision and RFID based system for multiple rodent tracking and behavioral assessment.

Fong, T.; Jury, B.; Hu, H.; MURPHY, T. H.

10.1101/2022.01.23.477395 — neuroscience — Posted on 2022-01-25

982 Rubisco forms a lattice inside alpha-carboxysomes

Metskas, L. A.; Ortega, D. R.; Oltrogge, L. M.; Blikstad, C.; Laughlin, T.; Savage, D.; Jensen, G. J.

10.1101/2022.01.24.477598 — biophysics — Posted on 2022-01-25

983 Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA

Navarro, I. C.; Suen, K. M.; Bensaddek, D.; Tanpure, A.; Lamond, A. I.; Balasubramanian, S.; Miska, E. A.

10.1101/2022.01.24.477592 — biochemistry — Posted on 2022-01-25

984 No effect of monetary reward in a visual working memory task

van den Berg, R.; Zou, Q.; Li, Y.; Ma, W. J.

10.1101/767343 — animal behavior and cognition — Posted on 2022-01-25

985 LMM-MQM time series mapping - An application in a murine advanced intercross line identifies novel growth QTLs

Arends, D.; Hesse, D.; Kärst, S.; Heise, S.; Lyu, S.; Korkuc, P.; Delpero, M.; Mulligan, M. K.; Prins, P.; Brockmann, G. A.

10.1101/2022.01.23.477441 — genetics — Posted on 2022-01-25

986 Correction of the scientific production: publisher performance evaluation using a dataset of 4844 PubMed retractions.

Toma, C. S.; Padureanu, L.; Toma, B.

10.1101/2022.01.23.477400 — scientific communication and education — Posted on 2022-01-25

987 Manganese excess and deficiency affects photosynthesis and metabolism in Marchantia polymorpha

Krieger-Liszkay, A.; Messant, M.; Thomine, S.; Gakiere, B.; Guerard, F.; Gall, A.; Hennebelle, T.

10.1101/2022.01.24.477552 — plant biology — Posted on 2022-01-25

988 The m6A writer FIONA1 methylates the 3'UTR of FLC and controls flowering in Arabidopsis

Sun, B.; Bhati, K. K.; Edwards, A. K.; Petri, L.; Kruusvee, V.; Blaakmeer, A.; Dolde, U.; Rodrigues, V.; Straub, D.; Wenkel, S.

10.1101/2022.01.24.477497 — plant biology — Posted on 2022-01-25

989 Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

10.1101/2022.01.22.477323 — pharmacology and toxicology — Posted on 2022-01-25

990 Structure of ATP synthase under strain during catalysis

Guo, H.; Rubinstein, J. L.

10.1101/2022.01.24.477618 — biophysics — Posted on 2022-01-25

991 Investigating the entropic nature of membrane-mediated interactions driving the aggregation of peripheral proteins

Sadeghi, M.

10.1101/2022.01.24.477571 — biophysics — Posted on 2022-01-25

992 Structural and mechanistic basis of σ-dependent transcriptional pausing

Pukhrambam, C.; Molodtsov, V.; Kooshkbaghi, M.; Tareen, A.; Vu, H.; Skalenko, K. S.; Su, M.; Zhou, Y.; Winkelman, J. T.; Kinney, J. B.; Ebright, R. H.; Nickels, B. E.

10.1101/2022.01.24.477500 — biochemistry — Posted on 2022-01-25

993 A human DNA methylation atlas reveals principles of cell type-specific methylation and identifies thousands of cell type-specific regulatory elements

Loyfer, N.; Magenheim, J.; Peretz, A.; Cann, G.; Bredno, J.; Klochendler, A.; Fox-Fisher, I.; Shabi-Porat, S.; Hecht, M.; Pelet, T.; Moss, J.; Drawshy, Z.; Amini, H.; Moradi, P.; Nagaraju, S.; Bauman, D.; Shveiky, D.; Porat, S.; Rivkin, G.; Or, O.; Hirshoren, N.; Carmon, E.; Pikarsky, A.; Khalaileh, A.; Zamir, G.; Grinboim, R.; Abu Gazala, M.; Mizrahi, I.; Shussman, N.; Korach, A.; Wald, O.; Izhar, U.; Erez, E.; Yutkin, V.; Samet, Y.; Rotnemer Golinkin, D.; Spalding, K. L.; Druid, H.; Arner, P.; Shapiro, A. M. J.; Grompe, M.; Aravanis, A.; Venn, O.; Jamshidi, A.; Shemer, R.; Dor, Y.; Glaser, B

10.1101/2022.01.24.477547 — genomics — Posted on 2022-01-25

994 Forecasted trends of the new COVID-19 epidemic due to the Omicron variant in Thailand, 2022

Suphanchaimat, R.; Teekasap, P.; Nittayasoot, N.; Phaiyarom, M.; Cetthakrikul, N.

10.1101/2022.01.24.477479 — immunology — Posted on 2022-01-24

995 Predictive coding in ASD: inflexible weighting of prediction errors when switching from stable to volatile environments

Shi, Z.; Theisinger, L.; Allenmark, F.; Pistorius, R.; Mueller, H. J.; Falter-Wagner, C.

10.1101/2022.01.21.477218 — neuroscience — Posted on 2022-01-25

996 Morphological analysis of human and mouse dendritic spines reveals a morphological continuum and differences across ages and species

Ofer, N.; Benavides-Piccione, R.; DeFelipe, J.; Yuste, R.

10.1101/2022.01.24.477510 — neuroscience — Posted on 2022-01-25

997 Species-informative SNP markers for characterising freshwater prawns of genus Macrobrachium in Cameroon

Makombu, J. G.; Cheruiyot, E. K.; Stomeo, F.; Thuo, D.; Oben, P. M.; Oben, B. O.; Zango, P.; Mialhe, E.; Ngueguim, J. R.; Mujibi, F. D.

10.1101/2022.01.24.477480 — genomics — Posted on 2022-01-24

998 Assembly and comparative analysis of the complete mitochondrial genome of three Macadamia species (M. integrifolia, M. ternifolia and M. tetraphylla)

Niu, Y.; Lu, Y.; Song, W.; He, X.; Liu, Z.; Zheng, C.; Wang, S.; Shi, C.; Liu, J.

10.1101/2022.01.24.477484 — genomics — Posted on 2022-01-24

999 Initial assessment of the spatial learning, reversal, and sequencing task capabilities of knock-in rats with humanizing mutations in the Ass-coding region of App

D'Adamio, L.; Pham, H.; Yin, T.

10.1101/2022.01.24.477482 — neuroscience — Posted on 2022-01-24

1000 The sowing date changed the temperature and light conditions in the field modified the cadmium content of brown rice (Oryza sativa L.) by regulating the expression of Cd-related genes

Rang, Z.; Xiao, H.; Yi, Z.; Wang, X.; Chen, Q.; Kuang, Y.; Ao, H.

10.1101/2022.01.24.477481 — physiology — Posted on 2022-01-24

1001 Reactive Oxygen Species-induced Protein Carbonylation Promotes Deterioration of Physiological Activity of Wheat Seeds

Li, B.-B.; Zhang, S.-B.; Lv, Y.-Y.; Wei, S.; Hu, Y.

10.1101/2022.01.24.477486 — physiology — Posted on 2022-01-24

1002 Crystal structure of an RNA/DNA strand exchange junction

Cofsky, J. C.; Knott, G. J.; Gee, C. L.; Doudna, J. A.

10.1101/2022.01.24.477483 — biochemistry — Posted on 2022-01-24

1003 Characterising ontogeny of quantity discrimination in zebrafish

Sheardown, E.; Torres-Perez, J. V.; Anagianni, S.; Fraser, S.; Vallortigara, G.; Butterworth, B.; Miletto-Petrazzini, M. E.; Brennan, C. H.

10.1101/2021.02.25.432846 — animal behavior and cognition — Posted on 2022-01-24

1004 Proteostasis is differentially modulated by inhibition of translation initiation or elongation

Clay, K. J.; Yang, Y.; Petrascheck, M.

10.1101/2022.01.23.477418 — biochemistry — Posted on 2022-01-24

1005 The chromatin factor ROW cooperates with BEAF-32 in regulating long-range inducible genes

Herman, N.; Kadener, S.; Shifman, S.

10.1101/2021.03.08.434270 — genomics — Posted on 2022-01-24

1006 Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke

Brunner, C.; Lagumersindez Denis, N.; Gertz, K.; Grillet, M.; Montaldo, G.; Endres, M.; Urban, A.

10.1101/2022.01.19.476904 — neuroscience — Posted on 2022-01-24

1007 Directly interfacing brain and deep networks exposes non-hierarchical visual processing

Sexton, N. J.; Love, B. C.

10.1101/2021.06.28.450213 — neuroscience — Posted on 2022-01-24

1008 Energy efficient network activity from disparate circuit parameters

Deistler, M.; Macke, J. H.; Goncalves, P. J.

10.1101/2021.07.30.454484 — neuroscience — Posted on 2022-01-24

1009 Evolutionary conserved aspects of animal nutrient uptake and transport in sea anemone vitellogenesis

Lebouvier, M.; Miramon-Puertolas, P.; Steinmetz, P. R. H.

10.1101/2022.01.24.477498 — evolutionary biology — Posted on 2022-01-24

1010 Ligand-independent modulation of GIPR signaling by splice variants

Wang, M.-W.; Hang, K.; Shao, L.; Zhou, Q.; Zhao, F.; Dai, A.; Cai, X.; Stevens, R. C.; Yang, D.

10.1101/2022.01.24.477496 — molecular biology — Posted on 2022-01-24

1011 Nasally-delivered interferon-{lambda} protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron

Chong, Z.; Karl, C. E.; Halfmann, P. J.; Kawaoka, Y.; Winkler, E. S.; Yu, J.; Diamond, M. S.

10.1101/2022.01.21.477296 — microbiology — Posted on 2022-01-24

1012 A bite force database of 654 insect species

Ruehr, P. T.; Edel, C.; Frenzel, M.; Blanke, A.

10.1101/2022.01.21.477193 — zoology — Posted on 2022-01-24

1013 Becoming metrics literate: An analysis of brief videos that teach about the h-index

Maggio, L. A.; Jeffrey, A.; Haustein, S.; Samuel, A.

10.1101/2022.01.21.477291 — scientific communication and education — Posted on 2022-01-24

1014 Differences in durability of PARP inhibition by clinically approved PARP inhibitors: implications for combinations and scheduling

Smith, H. L.; Willmore, E. J.; Mukhopadhyay, A.; Drew, Y.; Curtin, N. J.

10.1101/2022.01.24.477471 — pharmacology and toxicology — Posted on 2022-01-24

1015 Significance of the RBD mutations in the SARS-CoV-2 Omicron: from spike opening to antibody escape and cell attachment

Hossen, M. L.; Baral, P.; Sharma, T.; Gerstman, B. S.; Chapagain, P. P.

10.1101/2022.01.21.477244 — biophysics — Posted on 2022-01-24

1016 The N764K and N856K mutations in SARS-CoV-2 Omicron S protein generate potential cleavage sites for SKI-1/S1P protease

maaroufi, H.

10.1101/2022.01.21.477298 — bioinformatics — Posted on 2022-01-24

1017 ArtSeg: Rapid Artifact Segmentation and Removal in Brightfield Cell Microscopy Images

Ali, M. A. S.; Hollo, K.; Laasfled, T.; Torp, J.; Tahk, M.-J.; Rinken, A.; Palo, K.; Parts, L.; Fishman, D.

10.1101/2022.01.24.477467 — bioinformatics — Posted on 2022-01-24

1018 Does the impact of cultivar mixtures on virulence dynamics in Zymoseptoria tritici populations persist after interseason sexual reproduction?

Orellana-Torrejon, C.; Vidal, T.; Saint-Jean, S.; Suffert, F.

10.1101/2022.01.24.477584 — ecology — Posted on 2022-01-24

1019 Global success in oyster reef restoration despite ongoing recovery debt

Hemraj, D. A.; Bishop, M. J.; Hancock, B.; Minuti, J. J.; Thurstan, R. H.; Zu Ermgassen, P. S. E.; Russell, B. D.

10.1101/2022.01.23.477429 — ecology — Posted on 2022-01-24

1020 Bacteriophage-derived dsRNA exerts anti-SARS-CoV-2 activity in vitro and in Golden Syrian hamsters in vivo

Vaivode, K.; Verhovcova, I.; Skrastina, D.; Petrovska, R.; Kreismane, M.; Lapse, D.; Rubene, D.; Kalnina, Z.; Pjanova, D.

10.1101/2022.01.22.477073 — microbiology — Posted on 2022-01-24

1021 Chemical-induced degradation of PreS2 mutant surface antigen reverses HBV- mediated hepatocarcinogenesis

Yang, J. Y.; Wu, Y.-H.; Pan, M. Y.-C.; Chiou, Y.-T.; Lee, R. K.-L.; Li, T.-N.; Wang, L.

10.1101/2022.01.24.477454 — microbiology — Posted on 2022-01-24

1022 Lack of Ronapreve (REGN-CoV; casirivimab and imdevimab) virological efficacy against the SARS-CoV 2 Omicron variant (B.1.1.529) in K18-hACE2 mice

Tatham, L.; Sharp, J.; Kijak, E.; Herriott, J.; Neary, M.; Box, H.; Valentijn, A.; Cox, H.; Pertinez, H.; Curley, P.; Arshad, U.; Rajoli, R. K.; Rannard, S.; Stewart, J.; Owen, A.

10.1101/2022.01.23.477397 — microbiology — Posted on 2022-01-24

1023 SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment

Bojkova, D.; Rothenburger, T.; Ciesek, S.; Wass, M. N.; Michaelis, M.; Cinatl, J.

10.1101/2022.01.20.477067 — microbiology — Posted on 2022-01-24

1024 Host Chitinase 3-like-1 is a Universal Therapeutic Target for the Delta, Omicron and Other SARS-CoV-2 Viral Variants in COVID 19

Kamle, S.; Ma, B.; Lee, C. M.; Schor, G.; Lee, C. G.; Elias, J. A.

10.1101/2022.01.21.477274 — immunology — Posted on 2022-01-24

1025 Impact of decision and action outcomes on subsequent decision and action behaviors

Saleri Lunazzi, C.; Thura, D.; Reynaud, A. J.

10.1101/2022.01.24.477509 — neuroscience — Posted on 2022-01-24

1026 A retroviral origin of vertebrate myelin

Ghosh, T.; Almeida, R. G.; Zhao, C.; Gonzalez M, G.; Stott, K.; Adams, I.; Rowitch, D. H.; Goldman, N.; Lyons, D. A.; Franklin, R. J.

10.1101/2022.01.24.477350 — neuroscience — Posted on 2022-01-24

1027 Lysophosphatidic acid, a CSF marker in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1

Toft-Bertelsen, T. L.; Barbuskaite, D.; Herfoordt, E. K.; Lolansen, S. D.; Andreassen, S. N.; Rostgaard, N.; Olsen, M. H.; Norager, N. H.; Capion, T.; Rath, M. F.; Juhler, M.; MacAulay, N.

10.1101/2022.01.24.477507 — neuroscience — Posted on 2022-01-24

1028 Mathematical Modeling of Thyroid Homeostasis: Implications for the Allan-Herndon-Dudley Syndrome

Wolff, T. M.; Veil, C.; Dietrich, J. W.; Mueller, M. A.

10.1101/2022.01.24.476744 — systems biology — Posted on 2022-01-24

1029 Integrating Math Modeling, Coding, and Biology in aCURE Lab

Dale, R.; Craig, S.

10.1101/2022.01.20.477155 — scientific communication and education — Posted on 2022-01-24

1030 The Hyaloperanospora arabidopsidis effector HaRxL77 is hypermobile between cells and manipulates host defence

Liu, X.; Bellandi, A.; Johnston, M. G.; Faulkner, C.

10.1101/2022.01.24.477405 — plant biology — Posted on 2022-01-24

1031 The Effect of Ethanolic Extract of Acacia Seyal Bark on Induced Diabetic rats

Elhasan, L. M.; Ahmed, B. A. E.; Abdelgadir, T. S.; Dafaallah, S. G. A.; Othman, O. M.

10.1101/2022.01.21.476925 — pharmacology and toxicology — Posted on 2022-01-24

1032 Multi-omics analysis combining pyroptosis-related signatures for building a prognosis prediction model in hepatocellular carcinoma

Huang, J.; Li, Y.; Chu, M.; Wang, Y.

10.1101/2022.01.24.477487 — cancer biology — Posted on 2022-01-24

1033 GAGAM: a genomic annotation-based enrichment of scATAC-seq data for Gene Activity Matrix

Martini, L.; Bardini, R.; Savino, A.; Di Carlo, S.

10.1101/2022.01.24.477458 — bioinformatics — Posted on 2022-01-24

1034 The monosialoganglioside GM1a protects trophoblasts, erythrocytes and endothelial cells against complement attack

Wedekind, H.; Beimdiek, J.; Rossdam, C.; Kats, E.; Wittek, V.; Schumann, L.; Tiede, A.; Buettner, F. F. R.; Weinhold, B.; Muenster-Kuehnel, A.; Abeln, M.

10.1101/2022.01.24.477475 — biochemistry — Posted on 2022-01-24

1035 Inversion of a topological domain leads to restricted changes in its gene expression and affects inter-domain communication

Galupa, R.; Picard, C.; Servant, N.; Nora, E. P.; Zhan, Y.; Bemmel, J. v.; El Marjou, F.; Johanneau, C.; Borensztein, M.; Ancelin, K.; Giorgetti, L.; Heard, E.

10.1101/2022.01.24.477495 — genomics — Posted on 2022-01-24

1036 Genome-wide analysis identifies Homothorax and Extradenticle as regulators of insulin in Drosophila Insulin-Producing cells

Winant, M.; Buhler, K.; Clements, J.; De Groef, S.; Hens, K.; Vulsteke, V.; Callaerts, P.

10.1101/2022.01.24.477491 — genetics — Posted on 2022-01-24

1037 Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence

Campellone, K. G.; Haarer, E. L.; Guo, S.

10.1101/2022.01.24.477450 — genetics — Posted on 2022-01-24

1038 Relation between the number of peaks and the number of reciprocal sign epistatic interactions

Saona, R.; Kondrashov, F. A.; Khudiakova, K. A.

10.1101/2022.01.23.477446 — evolutionary biology — Posted on 2022-01-24

1039 Assessing flower-visiting arthropod diversity in apple orchards through environmental DNA flower metabarcoding and visual census

Gamonal, N.; Hedegaard Sorensen, D.; Chua, P. Y. S.; Sigsgaard, L.

10.1101/2022.01.24.477478 — ecology — Posted on 2022-01-24

1040 Mechano-signaling feedback underlies precise inner hair cell patterning in the organ of Corti

Sprinzak, D.; Cohen, R.; Taiber, S.; Loza, O.; Kasirer, S.; Woland, S.

10.1101/2022.01.24.477468 — developmental biology — Posted on 2022-01-24

1041 Analysis of non-coding RNAs in Methylorubrum extorquens reveals a novel small RNA specific to Methylobacteriaceae

Boutet, E.; Djerroud, S.; Smail, K.; Lorain, M.-J.; Wu, M.; Lamarche, M. G.; Imane, R.; Miguez, C.; Perreault, J.

10.1101/2022.01.24.477521 — molecular biology — Posted on 2022-01-24

1042 Impaired ERK MAPK activation in mature osteoblasts enhances bone formation via the mTOR pathway

Kim, J.-M.; Yang, Y.-S.; Hong, J.; Chaugule, S.; Chun, H.; van der Meulen, M. C. H.; Xu, R.; Greenblatt, M. B.; Shim, J.-H.

10.1101/2022.01.24.477465 — molecular biology — Posted on 2022-01-24

1043 Type IV pili is a critical virulence factor in clinical isolates of Paenibacillus thiaminolyticus

Hehnly, C.; Shi, A.; Ssentongo, P.; Zhang, L.; Isaacs, A.; Morton, S. U.; Streck, N.; Erdmann-Gilmore, P.; Tolstoy, I.; Townsend, R. R.; Limbrick, D. D.; Paulson, J. N.; Ericson, J. E.; Galperin, M. Y.; Schiff, S. J.; Broach, J. R.

10.1101/2022.01.24.477451 — microbiology — Posted on 2022-01-24

1044 The first horse gut microbiome gene catalog reveals that rare microbiome ensures better cardiovascular fitness in endurance horses

Mach, N.; Midoux, C.; Leclercq, S.; Pennarun, S.; Le Moyec, L.; Rue, O.; Robert, C.; Salle, G.; Barrey, E.

10.1101/2022.01.24.477461 — microbiology — Posted on 2022-01-24

1045 Vaccinia virus attenuation by codon deoptimization of the A24R gene for vaccine development

Lorenzo, M.; Nogales, A.; Chiem, K.; Blasco, R.; Martinez-Sobrido, L.

10.1101/2022.01.23.477337 — microbiology — Posted on 2022-01-24

1046 Diet outweighs genetics in shaping gut microbiomes in Asian honeybee

Su, Q.; Tang, M.; Hu, J.; Tang, J.; Zhang, X.; Li, X.; Niu, Q.; Zhou, X.; Luo, S.; Zhou, X.

10.1101/2022.01.23.477436 — microbiology — Posted on 2022-01-24

1047 Multiplexed strain phenotyping defines consequences of genetic diversity in Mycobacterium tuberculosis for infection and vaccination outcomes

Carey, A. F.; Wang, X.; Cicchetti, N.; Spaulding, C. N.; Liu, Q.; Hopkins, F.; Brown, J.; Sixsmith, J.; Ioerger, T. R.; Fortune, S. M.

10.1101/2022.01.23.477410 — microbiology — Posted on 2022-01-24

1048 Single cell profiling reveals functional heterogeneity and serial killing in human peripheral and ex vivo-generated CD34+ progenitor derived Natural Killer cells

Subedi, N.; Verhagen, L. P.; de Jonge, P.; Van Eyndhoven, L. C.; van Turnhout, M. C.; Koomen, V.; Baudry, J.; Eyer, K.; Dolstra, H.; Tel, J.

10.1101/2022.01.24.477494 — immunology — Posted on 2022-01-24

1049 A novel neuroelectrophysiological age index implicates brain health and sleep disorders

Yook, S.; Park, H. R.; Park, C.; Park, G.; Lim, D. C.; Kim, J.; Joo, E. Y.; Kim, H.

10.1101/2022.01.24.477464 — neuroscience — Posted on 2022-01-24

1050 Imprinted genes Cdkn1c and Igf2 interact to promote terminal differentiation of adult NSCs

Lozano-Urena, A.; Jimenez-Villaba, E.; Lazaro-Carot, L.; Montalban-Loro, R.; Martinez-Gurrea, I.; Nakayama, K. I.; Kirstein, M.; Ferron, S. R.

10.1101/2022.01.24.477488 — neuroscience — Posted on 2022-01-24

1051 RNA-Targeting CRISPR/Cas13d System Eliminates Disease-Related Phenotypes in Pre-clinical Models of Huntington's Disease.

Morelli, K. H.; Wu, Q.; Gosztyla, M. L.; Liu, H.; Zhang, C.; Chen, J.; Marina, R.; Lee, K.; Jones, K. L.; Duan, W.; Yeo, G. W.

10.1101/2022.01.23.477417 — neuroscience — Posted on 2022-01-24

1052 Reduced resilience of functional state transitions in patients with anti-NMDA receptor encephalitis

von Schwanenflug, N.; Ramirez-Mahaluf, J. P.; Krohn, S.; Romanello, A.; Heine, J.; Pruess, H.; Crossley, N. K.; Finke, C.

10.1101/2022.01.24.477081 — neuroscience — Posted on 2022-01-24

1053 A brain atlas of the camouflaging dwarf cuttlefish, Sepia bandensis

Montague, T. G.; Rieth, I. J.; Gjerswold-Selleck, S.; Garcia-Rosales, D.; Aneja, S.; Elkis, D.; Zhu, N.; Kentis, S.; Rubino, F. A.; Nemes, A.; Wang, K.; Hammond, L. A.; Emiliano, R.; Ober, R. A.; Guo, J.; Axel, R.

10.1101/2022.01.23.477393 — neuroscience — Posted on 2022-01-24

1054 PyRodentTracks: flexible computer vision and RFID based system for multiple rodent tracking and behavioral assessment.

Fong, T.; Jury, B.; Hu, H.; MURPHY, T. H.

10.1101/2022.01.23.477395 — neuroscience — Posted on 2022-01-24

1055 Regional mutational signature activities in cancer genomes

Timmons, C.; Morris, Q.; Harrigan, C. F.

10.1101/2022.01.23.477261 — cancer biology — Posted on 2022-01-24

1056 Delineate clonal dynamics of ovarian cancer initiating cells during pre-malignant progression using a mouse genetic mosaic system

Zeng, J.; Casarez, E.; Jiang, Y.; Yela, A. A.; Kelly, B. E.; Ke, E.; Jenkins, T. M.; Atkins, K. A.; Janes, K. A.; Slack-Davis, J. K.; Zong, H.

10.1101/2022.01.23.477434 — cancer biology — Posted on 2022-01-24

1057 Probabilistic Learning of Treatment Trees in Cancer

Yao, T.-H.; Wu, Z.; Bharath, K.; Li, J.; Baladandayuthapani, V.

10.1101/2022.01.23.477414 — bioinformatics — Posted on 2022-01-24

1058 Pan-cancer analysis reveals the prognostic potential of THAP9/THAP9-AS1 Sense-Antisense gene pair in human cancer.

Rashmi, R.; Majumdar, S.

10.1101/2022.01.20.477092 — bioinformatics — Posted on 2022-01-24

1059 FiMO: Inferring the Temporal Order of Mutations on Clonal Phylogeny under Finite-sites Models

Zafar, H.; Agrawal, A. K.

10.1101/2022.01.23.477444 — bioinformatics — Posted on 2022-01-24

1060 A metric and its derived protein similarity network to analyze function-oriented ortholog

Yang, W.; Ji, J.; Ling, S.; Fang, G.

10.1101/2022.01.24.477246 — bioinformatics — Posted on 2022-01-24

1061 A robust and fast two-sample test of equal correlations with an application to differential co-expression

He, L.; Philipp, I.; Webster, S.; Kulminski, A.

10.1101/2022.01.23.477409 — bioinformatics — Posted on 2022-01-24

1062 plotsr: Visualising structural similarities and rearrangements between multiple genomes

Goel, M.; Schneeberger, K.

10.1101/2022.01.24.477489 — bioinformatics — Posted on 2022-01-24

1063 Augmenting Transcranial Magnetic Stimulation Coil with Magnetic Material: An Optimization Approach

Lu, C.; Deng, Z.-D.; Choa, F.-S.

10.1101/2022.01.21.477303 — bioengineering — Posted on 2022-01-24

1064 Variant to function mapping at single-cell resolution through network propagation

Yu, F.; Cato, L. D.; Weng, C.; Liggett, L. A.; Jeon, S.; Xu, K.; Chiang, C. W. K.; Wiemels, J. L.; Weissman, J. S.; Smith, A. J. d.; Sankaran, V. G.

10.1101/2022.01.23.477426 — genomics — Posted on 2022-01-24

1065 Marine invertebrate diversity and distribution; the evidence of human activities in Rommel Bay

Ibrahim, M. A. E.-A.; Zidan, I. M.

10.1101/2022.01.23.477416 — ecology — Posted on 2022-01-24

1066 Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors

Xu, G.; Zhang, R.; Li, H.; Yin, K.; Ma, X.; Lou, Z.

10.1101/2022.01.23.477411 — microbiology — Posted on 2022-01-24

1067 Reversal of obesogenic feeding and hypometabolism by a bifurcating GABAergic neural circuit

Han, Y.; He, Y.; Harris, L.; Xu, Y.; WU, Q.

10.1101/2022.01.23.477433 — neuroscience — Posted on 2022-01-24

1068 Latent circuit inference from heterogeneous neural responses during cognitive tasks

Langdon, C.; Engel, T. A.

10.1101/2022.01.23.477431 — neuroscience — Posted on 2022-01-24

1069 Rapid Selectivity to Natural Images Across Layers of Primate V1

Chen, X.; Zhu, S.; Bai, K.; Xia, R.; Kong, N. C. L.; Norcia, A. M.; Moore, T.

10.1101/2022.01.23.477422 — neuroscience — Posted on 2022-01-24

1070 Single-molecule nanopore dielectrophoretic trapping of α-Synuclein with lipid membranes

Wu, J.; Yamashita, T.; Hamilton, A. D.; Thompson, S.; Luo, J.

10.1101/2022.01.24.477462 — biochemistry — Posted on 2022-01-24

1071 Nascent Polypeptide Associated Complex-alpha and Signal Recognition Particle are required for cardiac development and remodeling

Schroeder, A. M.; Vogler, G.; Colas, A.; Bodmer, R.

10.1101/2022.01.24.477419 — developmental biology — Posted on 2022-01-24

1072 Multi-color dSTORM microscopy in Hormad1-/- spermatocytes reveals alterations in meiotic recombination intermediates and synaptonemal complex structure

Koornneef, L.; Slotman, J. A.; Sleddens-Linkels, E.; van Cappellen, W. A.; Toth, A.; Gribnau, J.; Houtsmuller, A. B.; Baarends, W. M.

10.1101/2022.01.24.477453 — developmental biology — Posted on 2022-01-24

1073 Chondroitin sulfates enhances the barrier function of basement membrane assembled by heparan sulfates

Tao, C.; Makrides, N.; Wu, Y.; Brooks, S. E.; Esko, J. D.; Zhang, X.

10.1101/2022.01.23.477428 — developmental biology — Posted on 2022-01-24

1074 Cryo-EM structure of an active central apparatus

Han, L.; Rao, Q.; Yang, R.; Wang, Y.; Chai, P.; Xiong, Y.; Zhang, K.

10.1101/2022.01.23.477438 — cell biology — Posted on 2022-01-24

1075 Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations

Lee, Y.; Haapanen, O.; Altmeyer, A.; Kühlbrandt, W.; Sharma, V.; Zickermann, V.

10.1101/2022.01.24.477492 — biochemistry — Posted on 2022-01-24

1076 Shelterin is a Dimeric Complex with Extensive Structural Heterogeneity

Zinder, J. C.; Olinares, P. D. B.; Svetlov, V.; Bush, M. W.; Nudler, E.; Chait, B. T.; Walz, T.; de Lange, T.

10.1101/2022.01.24.477420 — biochemistry — Posted on 2022-01-24

1077 Extracellular matrix deposition precedes muscle-tendon integration during murine forelimb morphogenesis

Leng, Y.; Lipp, S. N.; Bu, Y.; Larson, H.; Jacobson, K. R.; Calve, S.

10.1101/2022.01.23.477427 — developmental biology — Posted on 2022-01-24

1078 The AAA-ATPase Atad1 and its partners promote degradation of desmin intermediate filaments in muscle

Aweida, D.; Cohen, S.

10.1101/2022.01.24.477493 — cell biology — Posted on 2022-01-24

1079 Severe acute respiratory disease in American mink (Neovison vison) experimentally infected with SARS-CoV-2

Adney, D. R.; Lovaglio, J.; Schulz, J. E.; Yinda, C. K.; Avanzato, V. A.; Haddock, E.; Port, J. R.; Holbrook, M.; Hanley, P. W.; Saturday, G.; Scott, D.; Spengler, J. R.; Tansey, C.; Cossaboom, C.; Wendling, N.; Martens, C.; Easley, J.; Yap, S. W.; Seifert, S. N.; Munster, V. J.

10.1101/2022.01.20.477164 — microbiology — Posted on 2022-01-24

1080 A surface morphometrics toolkit to quantify organellar membrane ultrastructure using cryo-electron tomography

Barad, B. A.; Medina, M.; Fuentes, D.; Wiseman, R. L.; Grotjahn, D. A.

10.1101/2022.01.23.477440 — cell biology — Posted on 2022-01-24

1081 Nanoscale colocalization of NK cell activating and inhibitory receptors controls signal integration

Tomaz, D.; Pereira, P. M.; Guerra, N.; Dyson, J.; Gould, K.; Henriques, R.

10.1101/266429 — immunology — Posted on 2022-01-24

1082 Comprehensive visualization of cell-cell interactions in single-cell and spatial transcriptomics with NICHES

Raredon, M. S. B.; Yang, J.; Kothapalli, N.; Kaminski, N.; Niklason, L. E.; Kluger, Y.

10.1101/2022.01.23.477401 — bioinformatics — Posted on 2022-01-24

1083 Trichodesmium Erythraeum produces a higher photocurrent than other cyanobacterial species in bio-photo electrochemical cells.

Shlosberg, Y.; Spungin, D.; Holland, N.; Schuster, G.; Berman-Frank, I.; Adir, N.

10.1101/2022.01.23.477402 — microbiology — Posted on 2022-01-24

1084 In vitro analysis of catalase and superoxide dismutase mimetic properties of blue tattoo ink

Homolak, J.

10.1101/2022.01.23.477399 — pharmacology and toxicology — Posted on 2022-01-24

1085 Alternative Assembly of Qβ Virus Like Particles

Jin, X.; Shaw, V.; Sungsuwan, S.; McFall-Boegeman, H.; Huang, X.

10.1101/2022.01.23.477406 — biophysics — Posted on 2022-01-24

1086 On taming the effect of transcript level intra-condition count variation during differential expression analysis: a story of dogs, foxes and wolves

Lobo, D.; Godinho, R.; Archer, J.

10.1101/2022.01.24.477470 — bioinformatics — Posted on 2022-01-24

1087 Artisanal and farmers bread making practices differently shape fungal species diversity in French sourdoughs

Michel, E.; Masson, E.; Bubbendorf, S.; Lapicque, L.; Nidelet, T.; Segond, D.; Guezenec, S.; Marlin, T.; deVillers, H.; Rue, O.; Onno, B.; Legrand, J.; Sicard, D.

10.1101/679472 — ecology — Posted on 2022-01-24

1088 Tracking Genomic Characteristics across Oceanic Provinces: Contrasting Early and Mature Plastic Biofilm Communities

Bos, R. P.; Kaul, D.; Zettler, E. R.; Hoffman, J. M.; Dupont, C. L.; Amaral-Zettler, L. A.; Mincer, T. J.

10.1101/2022.01.23.477364 — ecology — Posted on 2022-01-24

1089 Hypoxia induces a transcriptional early primitive streak signature in pluripotent cells enhancing spontaneous elongation and lineage representation in gastruloids

Lopez-Anguita, N.; Gassaloglu, S. I.; Stötzel, M.; Typou, M.; Virta, I.; Hetzel, S.; Buschow, R.; Koksal, B.; Atilla, D.; Maitschke-Rajasekharan, R.; Chen, R.; Mattei, A. L.; Bedzhov, I.; Meierhofer, D.; Meissner, A.; Veenvliet, J. V.; Bulut-Karslioglu, A.

10.1101/2021.07.21.452906 — developmental biology — Posted on 2022-01-24

1090 Cell type diversity in a developing octopus brain

Styfhals, R.; Zolotarov, G.; Hulselmans, G.; Spanier, K. I.; Poovathingal, S.; Elagoz, A. M.; Deryckere, A.; Rajewsky, N.; Ponte, G.; Fiorito, G.; Aerts, S.; Seuntjens, E.

10.1101/2022.01.24.477459 — developmental biology — Posted on 2022-01-24

1091 In vitro maturation of Toxoplasma gondii bradyzoites in human myotubes and their metabolomic characterization

Christiansen, C.; Maus, D.; Hoppenz, E.; Melerowicz, F.; Scholz, J.; Murillo-Leon, M.; Steinfeldt, T.; Hoffmann, T.; Seeber, F.; Blume, M.

10.1101/2021.01.15.426845 — microbiology — Posted on 2022-01-24

1092 Optogenetic activation of the serotonergic neural circuit between dorsal raphe nucleus and the pre-Bötzinger complex contributes to inhibition of the seizure-induced respiratory arrest in the DBA/1 mouse SUDEP model

Ma, H.; Yu, Q.; Shen, Y.; Lian, X.; Gu, L.; lu, H.; Zhao, H.; Zeng, C.; Nagayasu, K.; Zhang, H.

10.1101/2020.12.04.410969 — neuroscience — Posted on 2022-01-24

1093 The amyloid precursor protein modulates the position and length of the axon initial segment offering a new perspective on Alzheimer's disease genetics

Ma, F.; Xu, J.; Liu, Y.; Popova, D.; Youssef, M.; Hart, R. P.; Herrup, K.

10.1101/2022.01.23.477413 — neuroscience — Posted on 2022-01-24

1094 PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons

Toskas, K.; Yaghmaeian-Salmani, B.; Skiteva, O.; Paslawski, W.; Gillberg, L.; Skara, V.; Antoniou, I.; Sodersten, E.; Svenningsson, P.; Chergui, K.; Ringner, M.; Perlmann, T.; Holmberg, J.

10.1101/2022.01.24.477226 — neuroscience — Posted on 2022-01-24

1095 Changes in blood cell deformability in Chorea-Acanthocytosis and effects of treatment with dasatinib or lithium

Reichel, F.; Kraeter, M.; Peikert, K.; Glass, H.; Rosendahl, P.; Herbig, M.; Prieto, A. R.; Kihm, A.; Kaestner, L.; Hermann, A.; Guck, J.

10.1101/2021.12.16.472921 — biophysics — Posted on 2022-01-24

1096 An analysis of LysM domain function in LytE when fulfilling the D,L-endopeptidase requirement for viability in Bacillus subtilis

Uelze, L.

10.1101/2022.01.12.475998 — genomics — Posted on 2022-01-24

1097 Early transition in foraging mode promoted greater reproductive effort in widely foraging lizards

Padilla Perez, D. J.; DeNardo, D. F.; Angilletta, M. J.

10.1101/2022.01.22.477347 — evolutionary biology — Posted on 2022-01-24

1098 Involvement of non-LTR retrotransposons in the cancer incidence and lifespan of mammals

Ricci, M.; Peona, V.; Taccioli, C.

10.1101/2021.09.27.461867 — evolutionary biology — Posted on 2022-01-24

1099 Analysis and extension of exact mean-field theory with dynamic synaptic currents

Ruffini, G.

10.1101/2021.09.01.458563 — neuroscience — Posted on 2022-01-24

1100 Probabilistic modeling methods for cell-free DNA methylation based cancer classification

Halla-aho, V.; Lähdesmäki, H.

10.1101/2021.06.18.444402 — bioinformatics — Posted on 2022-01-24

1101 WGS analysis of Listeria monocytogenes from rural, urban, and farm environments in Norway: Genetic diversity, persistence, and relation to clinical and food isolates

Fagerlund, A.; Idland, L.; Heir, E.; Moretro, T.; Aspholm, M. E.; Lindbäck, T.; Langsrud, S.

10.1101/2021.10.27.466212 — microbiology — Posted on 2022-01-24

1102 Genomic surveillance of Bacillus cereus sensu lato strains isolated from meat and poultry products in South Africa enables inter- and intra-national surveillance and source tracking

Carroll, L. M.; Pierneef, R.; Mathole, A.; Atanda, A.; Matle, I.

10.1101/2022.01.18.476746 — microbiology — Posted on 2022-01-24

1103 Identifying control ensembles for information processing within the cortico-basal ganglia-thalamic circuit

Vich, C.; Clapp, M.; Verstynen, T.; Rubin, J.

10.1101/2021.12.22.473901 — neuroscience — Posted on 2022-01-24

1104 Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation

Ahmed, M.; Kojima, Y.; Masai, I.

10.1101/2021.10.18.464758 — developmental biology — Posted on 2022-01-24

1105 Development and validation of Arc nanobodies: new tools for probing Arc dynamics and function

Ishizuka, Y.; Mergiya, T. F.; Baldinotti, R.; Xu, J.; Hallin, E. I.; Markusson, S.; Kursula, P.; Bramham, C. R.

10.1101/2022.01.20.477070 — neuroscience — Posted on 2022-01-24

1106 Conformational decoupling in acid-sensing ion channels uncovers mechanism and stoichiometry of PcTx1-mediated inhibition

Heusser, S. A.; Borg, C. B.; Colding, J.; Pless, S. A.

10.1101/2021.06.21.449215 — biophysics — Posted on 2022-01-24

1107 Assessing Reproducibility of High-throughput Experiments in the Case of Missing Data.

Singh, R.; Zhang, F.; Li, Q.

10.1101/2021.07.10.451851 — bioinformatics — Posted on 2022-01-24

1108 Weighted transitivity scores that account for triadic edge similarity in undirected graphs

Peron, G.

10.1101/2022.01.11.475816 — bioinformatics — Posted on 2022-01-24

1109 Antagonistic Co-contraction Can Minimize Muscular Effort in Systems with Uncertainty

Koelewijn, A. D.; van den Bogert, A. J.

10.1101/2020.07.07.191197 — bioengineering — Posted on 2022-01-24

1110 Tempo of degeneration across independently evolved non-recombining regions

Carpentier, F.; Rodriguez De La Vega, R.; Jay, P.; Duhamel, M.; Shykoff, J. A.; Perlin, M. H.; Wallen, M.; Hood, M.; Giraud, T.

10.1101/2021.07.20.453045 — evolutionary biology — Posted on 2022-01-24

1111 Gut Microbiome of Helminth Infected Indigenous Malaysians Is Context Dependent

Tee, M. Z.; Er, Y. X.; Easton, A. V.; Yap, N. J.; Lee, I. L.; Devlin, J.; Chen, Z.; Ng, K. S.; Subramanian, P.; Angelova, A.; Sargsian, S.; Ngui, R.; Boey, C. C. M.; Chua, K. H.; Cadwell, K.; Lim, Y. A. L.; Loke, P.; Lee, S. C.

10.1101/2022.01.21.477162 — microbiology — Posted on 2022-01-24

1112 Fever temperatures impair hemolysis caused by strains of Escherichia coli and Staphylococcus aureus

Palela, M.; Giol, E. D.; Amzuta, A.; Ologu, O.; Stan, R.

10.1101/2020.11.23.393553 — microbiology — Posted on 2022-01-24

1113 The convergence and divergence of episodic and semantic functions across lateral parietal cortex

Humphreys, G. F.; Jung, J.; Lambon Ralph, M.

10.1101/2020.12.08.416123 — neuroscience — Posted on 2022-01-24

1114 A scalp geometry parameter-space for optimization and implementation of conventional TMS coil placement

Jiang, Y.; Du, B.; Chen, Y.; Wei, L.; Cao, Z.; Zhang, Z.; Xie, C.; Li, G.; Cai, Z.; Li, Z.; Zhu, C.

10.1101/2022.01.22.477370 — neuroscience — Posted on 2022-01-24

1115 Conserved mechanism for perception of root-active CLE peptides

Hazak, O.; Carbonnel, S.; Falquet, L.

10.1101/2022.01.21.477294 — plant biology — Posted on 2022-01-24

1116 Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivity.

Kjolby, M.; Breining, P.; Pedersen, K. M.; Wellner, N.; Sorensen, K. M. J.; Gjessing, A. M. P.; Januliene, D.; Vittrup, D. M.; Manavalan, A.; Rotman, M.; Thotakura, G.; Hermey, G.; Madsen, P.; Vaegter, C. B.; Thirup, S.; Asplund, O.; Prasad, R.; Parlevliet, E.; Rensen, P. C. N.; Madsen, A. N.; Holst, B.; Andersen, O. M.; Moller, A.; Hansen, T.; Nykjaer, A.

10.1101/2020.11.10.376178 — physiology — Posted on 2022-01-24

1117 SPCS: A Spatial and Pattern Combined Smoothing Method of Spatial Transcriptomic Expression

Liu, Y.; Wang, T.; Duggan, B.; Huang, K.; Zhang, J.; Ye, X.; Johnson, T.

10.1101/2021.11.02.467030 — bioinformatics — Posted on 2022-01-24

1118 Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in brain phenotypes and unveils a new role for the major vault protein

Kretz, P.; Wagner, C.; Montillot, C.; Hugel, S.; Morella, I.; Brambilla, R.; Herault, Y.; Reymond, A.; Selloum, M.; Collins, S.; Yalcin, B.

10.1101/2022.01.23.477432 — genetics — Posted on 2022-01-24

1119 Hotspots of pest-induced US urban tree death, 2020-2050

Hudgins, E. J.; Koch, F. H.; Ambrose, M. J.; Leung, B.

10.1101/2021.04.24.441210 — ecology — Posted on 2022-01-23

1120 Dietary fat promotes antibiotic-induced Clostridioides difficile mortality in mice

Hazleton, K. Z.; Martin, C. G.; Orlicky, D. J.; Arnolds, K. L.; Nusbacher, N. M.; Moreno-Huizar, N.; Armstrong, M. L.; Reisdorph, N.; Lozupone, C. A.

10.1101/828939 — microbiology — Posted on 2022-01-23

1121 Pupil diameter tracked during motor adaptation in humans

Yokoi, A.; Weiler, J.

10.1101/2021.04.03.438075 — neuroscience — Posted on 2022-01-23

1122 The demographic costs of sexually antagonistic selection in partially selfing populations

Olito, C.; de Vries, C.

10.1101/2022.01.23.477381 — evolutionary biology — Posted on 2022-01-23

1123 Interpreting the Evolutionary Echoes of a Protein Complex Essential for Inner-Ear Mechanosensation

Nisler, C. R.; Narui, Y.; Choudhary, D.; Bowman, J. D.; Lynch, V. J.; Sotomayor, M.

10.1101/2022.01.23.477425 — evolutionary biology — Posted on 2022-01-23

1124 Variation in white spruce needle respiration at the species range limits: a potential impediment to northern expansion

Griffin, K. L.; Griffin, Z. M.; Schmiege, S. C.; Bruner, S. G.; Boelman, N. T.; Vierling, L. A.; Eitel, J. U.

10.1101/2021.08.18.456715 — plant biology — Posted on 2022-01-23

1125 Characterization of methylation profiles in spontaneous preterm birth placental villous tissue

Brockway, H. M.; Wilson, S. L.; Kallapur, S. G.; Buhimschi, C. S.; Muglia, L. J.; Jones, H.

10.1101/2021.04.26.441471 — physiology — Posted on 2022-01-23

1126 Identification of Piperlongumine (PL) as a new E3 ligase ligand to induce targeted protein degradation

Pei, J.; Xiao, Y.; Liu, X.; Hu, W.; Sobh, A.; Yuan, Y.; Zhou, S.; Hua, N.; Mackintosh, S. G.; Zhang, X.; Basso, K. B.; Kamat, M.; Yang, Q.; Licht, J. D.; Zheng, G.; Zhou, D.; Lv, D.

10.1101/2022.01.21.474712 — cancer biology — Posted on 2022-01-23

1127 Flap dynamics in pepsin-like aspartic proteases: a computational perspective using Plasmepsin-II and BACE-1 as model systems

Bhakat, S.; Soderhjelm, P.

10.1101/2020.04.27.062539 — biophysics — Posted on 2022-01-23

1128 Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases

Nguyen, T. T. L.; Gao, H.; Liu, D.; Ye, Z.; Lee, J.-H.; Shi, G.-x.; Copenhaver, K.; Zhang, L.; Wei, L.; Yu, J.; Zhang, C.; Li, H.; Wang, L.; Ordog, T.; Weinshilboum, R. M.

10.1101/2021.12.01.470787 — genomics — Posted on 2022-01-23

1129 How does the host community structure affect the epidemiological dynamics of emerging infectious diseases?

Voinson, M.; Smadi, C.; Billiard, S.

10.1101/2022.01.23.477158 — ecology — Posted on 2022-01-23

1130 Human genetic variations reveal Chromosomal Instability aiding Variants (CIVa) in kinetochore-microtubule associated proteins

Islam, A.; Manjarrez-Gonzalez, J. C.; Gore, T.; Song, X.; Draviam, V. M.

10.1101/2022.01.22.477339 — cell biology — Posted on 2022-01-23

1131 SARS-CoV-2 Viral Genes Compromise Survival and Functions of Human Pluripotent Stem Cell-derived Cardiomyocytes via Reducing Cellular ATP Level

Liu, J.; Zhang, Y.; Wu, S.; Han, L.; Wang, C.; Liu, S.; Simpson, E.; Liu, Y.; Wang, Y.; Shou, W.; Liu, Y.; Rubart-von der Lohe, M.; Wan, J.; Wan, J.; Yang, L.

10.1101/2022.01.20.477147 — molecular biology — Posted on 2022-01-23

1132 Stochastic resonance and bifurcations in a heterogeneous neuronal population explain intrinsic oscillatory patterns in entorhinal cortical stellate cells

Mittal, D.; Narayanan, R.

10.1101/2022.01.23.477388 — neuroscience — Posted on 2022-01-23

1133 Integrated analysis reveals FOXA1 and Ku70/Ku80 as direct targets of ivermectin in prostate cancer

Lv, S.; Wu, Z.; Luo, M.; Zhang, Y.; Zhang, J.; Pascal, L. E.; Wang, Z.; Wei, Q.

10.1101/2022.01.19.476914 — cancer biology — Posted on 2022-01-23

1134 D2BGAN: Dual Discriminator Bayesian Generative Adversarial Network for Deformable MR-Ultrasound Registration Applied to Brain Shift compensation

Rahmani, M.; Moghadssi, H.; Farnia, P.; Ahmadian, A.

10.1101/2022.01.22.477329 — bioengineering — Posted on 2022-01-23

1135 Real-time precision opto-control of chemical processes in live cells

Clark, M. G.; Gonzalez, G.; Aldana-Mendoza, J.; Carlsen, M. S.; Eakins, G. S.; Zhang, C.

10.1101/2022.01.23.477373 — bioengineering — Posted on 2022-01-23

1136 Mechanical strain stimulates COPII-dependent trafficking via Rac1

Farhan, H.; Phuyal, S.; Roca-Cusachs, P.; Geley, S.; Reiterer, V.; Teis, D.; Fankhauser, D.; Kahlhofer, J.; Le Roux, A.-L.; Baker, M.; Kazanietz, M.; Eriksson, L. A.; Mahdizadeh, S. J.; Djaerff, E.

10.1101/2022.01.23.477215 — cell biology — Posted on 2022-01-23

1137 A highly attenuated Vesiculovax vaccine rapidly protects nonhuman primates against lethal Marburg virus challenge

Woolsey, C.; Cross, R. W.; Agans, K. N.; Borisevich, V.; Deer, D. J.; Geisbert, J. B.; Gerardi, C.; Lantham, T. E.; Fenton, K. A.; Egan, M.; Eldridge, J. H.; Geisbert, T. W.; Matassov, D.

10.1101/2022.01.22.477345 — microbiology — Posted on 2022-01-23

1138 Keystone species determine the productivity of synthetic microbial biofilm communities

Sun, X.; Xie, J.; Zheng, D.; Wang, W.; Xia, R.; Zhang, R.; Kovacs, A. T.; Xu, Z.; Shen, Q.

10.1101/2022.01.23.477386 — microbiology — Posted on 2022-01-23

1139 Extraversion is associated with lower brain amyloid deposition in cognitively normal older adults.

Oh, H.

10.1101/2022.01.23.477394 — neuroscience — Posted on 2022-01-23

1140 A scalp geometry parameter-space for optimization and implementation of conventional TMS coil placement

Jiang, Y.; Du, B.; Chen, Y.; Wei, L.; Cao, Z.; Zhang, Z.; Xie, C.; Li, G.; Cai, Z.; Li, Z.; Zhu, C.

10.1101/2022.01.22.477370 — neuroscience — Posted on 2022-01-23

1141 4R-Tobacco-Cembranoid is a Positive Allosteric Modulator of the Alpha7 Nicotinic Acetylcholine Receptor that modulates inflammation-induced thermal hypersensitivity in mice

Rivera-Garcia, L. G.; Francis Malave, A. M.; Wilson, T. D.; Ferchmin, P. A.; Eterovic, V.; Carrasquillo, Y.

10.1101/2022.01.22.477375 — neuroscience — Posted on 2022-01-23

1142 Evaluation of Various Drugs' Influence on Alzheimer's Disease Progress Using a New Analytical Model Based on Cellular Automata

Jafari, N.; Golabi, F.; Ebrahimi-kalan, A.; Sarbaz, Y.

10.1101/2022.01.23.477385 — systems biology — Posted on 2022-01-23

1143 Identification of Piperlongumine (PL) as an new E3 ligase ligand to induce targeted protein degradation

Pei, J.; Xiao, Y.; Liu, X.; Hu, W.; Sobh, A.; Yuan, Y.; Zhou, S.; Hua, N.; Mackintosh, S. G.; Zhang, X.; Basso, K. B.; Kamat, M.; Yang, Q.; Licht, J. D.; Zheng, G.; Zhou, D.; Lv, D.

10.1101/2022.01.21.474712 — cancer biology — Posted on 2022-01-23

1144 Human glioblastoma cell motility depends on the activity of the cysteine metabolism enzyme 3-Mercaptopyruvate sulfurtransferase

Saurty-Seerunghen, M. S.; Daubon, T.; Bellenger, L.; Delaunay, V.; Castro, G.; Guyon, J.; Rezk, A.; Fabrega, S.; Idbaih, A.; Almairac, F.; Burel-Vandenbos, F.; Turchi, L.; Virolle, T.; Peyrin, J.-M.; Antoniewski, C.; Chneiweiss, H.; El-Habr, E. A.; Junier, M.-P.

10.1101/2022.01.21.477271 — cancer biology — Posted on 2022-01-23

1145 Alphavirus nsP2 protease structure and cleavage prediction: Possible relevance to the pathogenesis of viral arthritis

Prescott, L.

10.1101/2022.01.22.477317 — bioinformatics — Posted on 2022-01-23

1146 Lipid-polymer hybrid nanoparticles utilize B cells and dendritic cells to elicit distinct antigen-specific CD4+ and CD8+ T cell responses

Zhang, M. H.; Scotland, B. L.; Jiao, Y.; Slaby, E. M.; Truong, N.; Stephanie, G.; Pearson, R. M.; Szeto, G. L.

10.1101/2022.01.23.477398 — bioengineering — Posted on 2022-01-23

1147 Context-aware information selection and model recommendation with ACCORDION

Ahmed, Y.; Telmer, C.; Miskov-Zivanov, N.

10.1101/2022.01.22.477231 — systems biology — Posted on 2022-01-23

1148 Evaluating the Phytotoxicity of Methanolic Extracts of Parthenium hysterophorus L. on Selected Crops and Weeds

Bashar, H. M. K. M. K.; Juraimi, A. S.; Ahmad Hamdani, M. S.; Uddin, M. K.; Asib, N.; Anwar, M. P.; Rahaman, F.; Haque, M. A.; Hossain, A.

10.1101/2022.01.21.477310 — plant biology — Posted on 2022-01-23

1149 The interplay of active and passive mechanisms in slow axonal transport

Maiya, R.; Dey, S.; Ray, K.; Menon, G. I.

10.1101/2022.01.23.477383 — biophysics — Posted on 2022-01-23

1150 Time-resolved parameterization of aperiodic and periodic brain activity

Wilson, L. E.; da Silva Castanheira, J.; Baillet, S.

10.1101/2022.01.21.477243 — neuroscience — Posted on 2022-01-23

1151 Universal guide for skull extraction and custom-fitting of implants to continuous and discontinuous skulls

Ahmed, Z.; Agha, N. S.; Trunk, A.; Berger, M.; Gail, A.

10.1101/2022.01.22.475298 — neuroscience — Posted on 2022-01-23

1152 Common synaptic inputs are not distributed homogeneously among the motor neurons that innervate synergistic muscles

Del Vecchio, A.; Germer, C. M.; Kinfe, T. M.; Nuccio, S.; Hug, F.; Eskofier, B.; Farina, D.; Enoka, R. M.

10.1101/2022.01.23.477379 — neuroscience — Posted on 2022-01-23

1153 Tracing 3D apoplasmic complexity in vascular tissue of live conifer needles by X-ray computed tomography

Gao, C.; Marker, S. J. V.; Gundlach, C.; Poulsen, H. F.; Bohr, T.; Schulz, A.

10.1101/2022.01.22.477321 — plant biology — Posted on 2022-01-23

1154 The relaxin receptor RXFP1 signals through a mechanism of autoinhibition

Erlandson, S. C.; Rawson, S.; Brock, K. P.; Liu, X.; Paulo, J. A.; Mintseris, J.; Gygi, S. P.; Marks, D. S.; Cong, X.; Kruse, A. C.

10.1101/2022.01.22.477343 — pharmacology and toxicology — Posted on 2022-01-23

1155 Multi-curve fitting and tubulin-lattice signal removal for structure determination of large microtubule-based motors

Chai, P.; Rao, Q.; Zhang, K.

10.1101/2022.01.22.477366 — biophysics — Posted on 2022-01-23

1156 A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys

Qu, J.; Yang, F.; Zhu, T.; Wang, Y.; Fang, W.; Ding, Y.; Zhao, X.; Qi, X.; Xie, Q.; Xu, Q.; Xie, Y.; Sun, Y.; Chen, D.

10.1101/2022.01.22.477221 — bioinformatics — Posted on 2022-01-23

1157 Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning

Neto, N. G. B.; O'Rourke, S. A.; Zhang, M.; Fitzgerald, H. K.; Dunne, A.; Monaghan, M. G.

10.1101/2022.01.22.477332 — bioengineering — Posted on 2022-01-23

1158 Alteration of myocardial structure and function in RAF1associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs

Nakhaei-Rad, S.; Bazgir, F.; Dahlmann, J.; Busley, A. V.; Buchholzer, M.; Haghighi, F.; Schaenzer, A.; Hahn, A.; Koetter, S.; Schanze, D.; Anand, R.; Funk, F.; Borchardt, A.; Kronenbitter, A. V.; Scheller, J.; Piekorz, R. P.; Reichert, A.; Volleth, M.; Wolf, M. J.; Cirstea, I. C.; Gelb, B. D.; Tartaglia, M.; Schmitt, J.; Krueger, M.; Kutschka, I.; Cyganek, L.; Zenker, M.; Kensah, G.; Ahmadian, M. R.

10.1101/2022.01.22.477319 — cell biology — Posted on 2022-01-23

1159 Amphibian mucus triggers a developmental transition in the frog-killing chytrid fungus

Robinson, K. A.; Prostak, S. M.; Grant, E. H. C.; Fritz-Laylin, L.

10.1101/2022.01.21.477224 — cell biology — Posted on 2022-01-23

1160 Crosstalk of Histone Modifications in the Healthy Human Immune System

Dermadi, D.; Kalesinskas, L.; Ganesan, A.; Kuo, A.; Cheung, P.; Cheng, S.; Dvorak, M.; Scriba, T.; Habtezion, A.; Donato, M.; Utz, P. J.; Khatri, P.

10.1101/2022.01.21.477300 — immunology — Posted on 2022-01-23

1161 Look-up and look-down neurons in the mouse visual thalamus during freely moving exploration

Orlowska-Feuer, P.; Ebrahimi, A. S.; Zippo, A. G.; Petersen, R.; Lucas, R. J.; Storchi, R.

10.1101/2022.01.22.477320 — neuroscience — Posted on 2022-01-23

1162 Improved production and expanded application of CVS-N2c-ΔG virus for retrograde tracing

Lin, K.; Li, L.; Ma, W.; Yang, X.; Han, Z.; Luo, N.; Xu, F.

10.1101/2022.01.22.477330 — neuroscience — Posted on 2022-01-23

1163 Amacrine cells shape retinal functions while dynamically preserving circuits for colour vision

Wang, X.; Roberts, P. A.; Yoshimatsu, T.; Lagnado, L.; Baden, T.

10.1101/2022.01.22.477338 — neuroscience — Posted on 2022-01-23

1164 Targeting Noradrenergic Neurons of the Locus Coeruleus: A Comparison of Model Systems and Strategies

Wissing, C.; Maheu, M.; Wiegert, J. S.; Dieter, A.

10.1101/2022.01.22.477348 — neuroscience — Posted on 2022-01-23

1165 An in vitro neuronal model replicating the in vivo maturation and heterogeneity of perineuronal nets

Dickens, S.; Goodenough, A.; Kwok, J. C. F.

10.1101/2022.01.22.477344 — neuroscience — Posted on 2022-01-23

1166 The positive dimension of schizotypy is associated with a reduced attenuation and precision of self-generated touch

Asimakidou, E.; Job, X.; Kilteni, K.

10.1101/2022.01.22.476743 — neuroscience — Posted on 2022-01-23

1167 Focusing perceptual attention in one modality constrains subsequent learning in another modality

Vasilev, D.; Watanabe, M.; Logothetis, N. K.; Totah, N. K.

10.1101/2022.01.22.477334 — neuroscience — Posted on 2022-01-23

1168 Reference-based comparison of adaptive immune receptor repertoires

Weber, C. R.; Rubio, T.; Wang, L.; Zhang, W.; Robert, P. A.; Akbar, R.; Snapkov, I.; Wu, J.; Kuijjer, M. L.; Campos, S. T.; Conesa, A.; Sandve, G. K.; Liu, X.; Reddy, S. T.; Greiff, V.

10.1101/2022.01.23.476436 — systems biology — Posted on 2022-01-23

1169 Impact of a native hemiparasite and mowing on performance of a major invasive weed, European blackberry

Cirocco, R. M.; Watling, J. R.; Facelli, J. M.

10.1101/2022.01.22.477376 — plant biology — Posted on 2022-01-23

1170 Targeted photothrombotic stroke leads to disruptions in neurovascular coupling

Sunil, S.; Jiang, J.; Shah, S.; Kura, S.; Kilic, K.; Erdener, S. E.; Ayata, C.; Devor, A.; Boas, D. A.

10.1101/2022.01.22.477341 — physiology — Posted on 2022-01-23

1171 The effector protein CgNLP1 of Colletotrichum gloeosporioides from Hevea brasiliensis disrupts nuclear localization of necrosis-induced transcription factor HbMYB8-like to suppress plant defense signaling

Yang, G.; Yang, J.; Zhang, Q.; Wang, W.; Feng, L.; Zhao, L.; An, B.; Wang, Q.; He, C.; Luo, H.

10.1101/2022.01.23.477367 — pathology — Posted on 2022-01-23

1172 Towards a structurally resolved cancer interactome

Zhang, J.; Pei, J.; Durham, J.; Bos, T.; Cong, Q.

10.1101/2022.01.21.477304 — bioinformatics — Posted on 2022-01-23

1173 FAME: Fragment-based Conditional Molecular Generation for Phenotypic Drug Discovery

Pham, T.-H.; Xie, L.; Zhang, P.

10.1101/2022.01.21.477292 — bioinformatics — Posted on 2022-01-23

1174 Immune-responsive biodegradable scaffolds for enhancing neutrophil regeneration

Kerr, M.; McBride, D.; Johnson, W.; Chumber, A.; Najibi, A.; Seo, B. R.; Stafford, A.; Scadden, D.; Mooney, D.; Shah, N.

10.1101/2022.01.21.477275 — bioengineering — Posted on 2022-01-23

1175 Transcriptional mapping of the macaque retina and RPE-choroid reveals conserved inter-tissue transcription drivers and signaling pathways

Mungales, A.; McGaughey, D.; Zhang, C.; Yousaf, S.; Liu, J.; Brooks, B.; Maminishkis, A.; Fufa, T.; Hufnagel, R.

10.1101/2022.01.21.477280 — genomics — Posted on 2022-01-23

1176 The spatial scale of adaptation in a native annual plant and its implications for responses to climate change

Gorton, A.; Benning, J. W.; Tiffin, P.; Moeller, D.

10.1101/2022.01.22.477135 — evolutionary biology — Posted on 2022-01-23

1177 Plant longevity, drought and island isolation favoured rampant evolutionary transitions towards insular woodiness

Zizka, A.; Onstein, R. E.; Rozzi, R.; Weigelt, P.; Kreft, H.; Steinbauer, M. J.; Bruelheide, H.; Lens, F.

10.1101/2022.01.22.477210 — evolutionary biology — Posted on 2022-01-23

1178 Modified dN/dS for accounting transition and transversion frequency difference and non-sense substitution in genomes

Aziz, R.; Sen, P.; Beura, P. K.; Dash, M.; Namsa, N. D.; Deka, R. C.; Das, D.; Feil, E.; Satapathy, S. S.; Ray, S. K.

10.1101/2022.01.22.477328 — evolutionary biology — Posted on 2022-01-23

1179 Single-Cell Transcriptomics reveals relaxed evolutionary constraint of spermatogenesis in two passerine birds as compared to mammals

Segami Marzal, J. C.; Semon, M.; Cunha, C.; Bergin, C.; Mugal, C. F.; Qvarnstrom, A.

10.1101/2022.01.22.477241 — evolutionary biology — Posted on 2022-01-23

1180 Characterizing Potential Tetrodotoxin Resistance in Domain IV of the Voltage-Gated Sodium Channel Nav1.4 of Pacific Chorus Frogs, Pseudacris regilla

Montana, K. O.; Ramirez Castaneda, V.; Tarvin, R. D.

10.1101/2022.01.22.475505 — evolutionary biology — Posted on 2022-01-23

1181 Brain temperature affects quantitative features of hippocampal sharp wave ripples

Petersen, P. C.; Vöröslakos, M.; Buzsaki, G.

10.1101/2022.01.21.477285 — neuroscience — Posted on 2022-01-23

1182 PERSISTENT RELIEF OF MOTOR SYMPTOMS IN A PARKINSONIAN MOUSE MODEL AFTER INDUCTION OF LTD AT CORTICAL INPUTS TO INDIRECT PATHWAY STRIATAL NEURONS

Abburi, C.; Thome, J.; Rodriguez, B.; Zhuang, X.; McGehee, D. S.

10.1101/2022.01.21.477283 — neuroscience — Posted on 2022-01-23

1183 White matter connections of high-level visual areas predict cytoarchitecture better than category-selectivity

Kubota, E.; Grotheer, M.; Finzi, D.; Natu, V. S.; Gomez, J.; Grill-Spector, K.

10.1101/2022.01.21.477131 — neuroscience — Posted on 2022-01-23

1184 Brain-optimized neural networks learn non-hierarchical models of representation in human visual cortex

St-Yves, G.; Allen, E. J.; Wu, Y.; Kay, K.; Naselaris, T.

10.1101/2022.01.21.477293 — neuroscience — Posted on 2022-01-23

1185 Glaucoma and Alzheimer: Neurodegenerative disorders show an adrenergic dysbalance

Hohberger, B.; Pruess, H. P.; Mardin, C.; Laemmer, R.; Mueller, J.; Wallukat, G.

10.1101/2022.01.22.477197 — neuroscience — Posted on 2022-01-23

1186 Conserved mechanism for perception of root-active CLE peptides

Hazak, O.; Carbonnel, S.; Falquet, L.

10.1101/2022.01.21.477294 — plant biology — Posted on 2022-01-23

1187 A Cyclisation and Docking Protocol for Cyclic Peptide-Protein Modelling using HADDOCK2.4

Charitou, V.; van Keulen, S. C.; Bonvin, A.

10.1101/2022.01.21.477251 — bioinformatics — Posted on 2022-01-23

1188 Histochemical Examination of Changes In Testis After Vasectomy In Rats And Qualitative Analysis Of Tissue Zinc Content

Ozcinar, E.; Canillioglu, Y.; Cetinel, S.

10.1101/2022.01.21.477201 — developmental biology — Posted on 2022-01-23

1189 Delayed Oligodendrocyte Progenitor Cell Recruitment and Maturation in Large Volume Demyelination

Cooper, J. J. M.; Polanco, J. J.; Saraswat, D.; Peirick, J.; Sim, F.

10.1101/2022.01.21.477229 — neuroscience — Posted on 2022-01-23

1190 Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis

Abdallah, M.; Zanitti, G. E.; Iovene, V.; Wassermann, D.

10.1101/2022.01.21.477198 — neuroscience — Posted on 2022-01-23

1191 DelaySSAToolkit.jl: stochastic simulation of reaction systems with time delays in Julia

Fu, X.; Zhou, X.; Gu, D.; Cao, Z.; Grima, R.

10.1101/2022.01.21.477236 — systems biology — Posted on 2022-01-23

1192 Factors affecting post-breeding endometritis, pregnancy rate and embryonic/fetal death in sport mares in two French commercial stud farms: special focus on age, parity and lactating status effects

Derisoud, E.; Grimard, B.; Gourtay, C.; Chavatte-Palmer, P.

10.1101/2022.01.21.477204 — systems biology — Posted on 2022-01-23

1193 A unified Method for assessing the Observability of Dynamic Complex Systems in Biology

Diaz Ochoa, J. G.

10.1101/2022.01.21.477230 — systems biology — Posted on 2022-01-23

1194 Computational Model of Heterogeneity in Melanoma: Designing Therapies and Predicting Outcomes

Hodgkinson, A.; Trucu, D.; Lacroix, M.; Le Cam, L.; Radulescu, O.

10.1101/2022.01.21.477232 — systems biology — Posted on 2022-01-23

1195 Scale-Dependent Coherence of Terrestrial Vertebrate Biodiversity with Environment

O'Malley, C. P. B.; Roberts, G. G.; Mannion, P. D.; Hackel, J.; Wang, Y.

10.1101/2022.01.21.477239 — systems biology — Posted on 2022-01-23

1196 Probabilistic Edge Weights Fine-tune Boolean Network Dynamics

Deritei, D.; Kunsic, N.; Csermely, P.

10.1101/2022.01.21.477240 — systems biology — Posted on 2022-01-23

1197 A draft genome assembly for the heterozygous wild tomato Solanum habrochaites highlights haplotypic structural variations of intracellular immune receptors

Seong, K.; Lunde, C.; Seo, E.; Li, M.; Krasileva, K.; Staskawicz, B.

10.1101/2022.01.21.477156 — plant biology — Posted on 2022-01-23

1198 Conserved Structural Motifs in the Hammerhead Ribozyme of a Chloroplast Viroid Mimic tRNA Anticodon Structure to Hijack tRNA Ligase for Viroid Circularization

Ortola, B.; Daros, J.-A.

10.1101/2022.01.19.477025 — plant biology — Posted on 2022-01-23

1199 Ethylene augments root hypoxia tolerance through amelioration of reactive oxygen species and growth cessation

Liu, Z.; Hartman, S.; van Veen, H.; Zhang, H.; Leeggangers, H. A.; Martopawiro, S.; Bosman, F.; de Deugd, F.; Su, P.; Hummel, M.; Rankenberg, T.; Hassall, K.; Bailey-Serres, J.; Theodoulou, F.; Voesenek, L. A.; Sasidharan, R.

10.1101/2022.01.21.477196 — plant biology — Posted on 2022-01-23

1200 Out of sight: Surveillance strategies for emerging vectored plant pathogens.

Mastin, A. J.; van den Bosch, F.; Bourhis, Y.; Parnell, S.

10.1101/2022.01.21.477248 — plant biology — Posted on 2022-01-23

1201 Energetic decoupling of phycobilisomes from photosystem II involved in nonphotochemical quenching in red algae

Chiang, Y.-H.; Huang, Y.-J.; Fu, H.-Y.

10.1101/2022.01.21.477255 — plant biology — Posted on 2022-01-23

1202 GM1 asymmetry in the membrane stabilizes pores

Aleksanyan, M.; Lira, R. B.; Steinkuehler, J.; Dimova, R.

10.1101/2022.01.21.477228 — biophysics — Posted on 2022-01-23

1203 Can double PPO mutations exist in a same allele and are such mutants functional?

Porri, A.; Burgos, N. R.

10.1101/2022.01.21.477186 — genetics — Posted on 2022-01-23

1204 chromMAGMA: regulatory element-centric interrogation of risk variants

Nameki, R.; Shetty, A.; Dareng, E.; Tyrer, J.; Lin, X.; The Ovarian Cancer Association Consortium, ; Pharoah, P.; Corona, R. I.; Kar, S.; Lawrenson, K.

10.1101/2022.01.21.477270 — genetics — Posted on 2022-01-23

1205 Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes

Vigue, L.; Croce, G.; Petitjean, M.; Ruppe, E.; Tenaillon, O.; Weigt, M.

10.1101/2022.01.21.477185 — evolutionary biology — Posted on 2022-01-23

1206 Within and among population differences in cuticular hydrocarbons in the seabird tick Ixodes uriae.

Dupraz, M.; Leroy, C.; Thorarinsson, T. L.; dEttorre, P.; McCoy, K.

10.1101/2022.01.21.477272 — ecology — Posted on 2022-01-23

1207 The UBR box E3 ligases Poe and Hyd are required for efficient Pericentrin degradation

Varadarajan, R.; Galletta, B. J.; Fagerstrom, C. J.; Plevock Haase, K.; Rusan, N. M.

10.1101/2022.01.21.477277 — developmental biology — Posted on 2022-01-23

1208 Prostaglandin E1 as therapeutic molecule for Nephronophthisis and related ciliopathies

Garcia, H.; Serafin, A.; Silbermann, F.; Poree, E.; Mahaut, C.; Viau, A.; Billot, K.; Birgy, E.; Garfa-Traore, M.; Roy, S.; Cecarelli, S.; Mehraz, M.; C. Rodriguez, P.; Deleglise, B.; Furio, L.; Jabot-Hanin, F.; Cagnard, N.; Del Nery, E.; Fila, M.; Sin-Monnot, S.; Antignac, C.; Lyonnet, S.; Krug, P.; Salomon, R.; Annereau, J.-P.; Benmerah, A.; Delous, M.; Briseno-Roa, L.; Saunier, S.

10.1101/2022.01.21.477191 — cell biology — Posted on 2022-01-23

1209 Neuro-toxicogenomic mapping of TMT induced neurotoxicity using human minibrain reveals associated adverse outcome events

Govindan, S.; Alpern, D.; Stoppini, L.; Deplancke, B.; Roux, A.

10.1101/2022.01.21.477206 — neuroscience — Posted on 2022-01-23

1210 REM sleep promotes bidirectional plasticity in developing visual cortex in vivo

Renouard, L.; Hayworth, C.; Rempe, M.; Clegern, W.; Wisor, J.; Frank, M. G.

10.1101/2022.01.21.477249 — neuroscience — Posted on 2022-01-23

1211 The role of rice SOG1 and SOG1-like in DNA damage response

Nishizawa-Yokoi, A.; Motoyama, R.; Tanaka, T.; Mori, A.; Iida, K.; Toki, S.

10.1101/2022.01.21.477278 — plant biology — Posted on 2022-01-23

1212 The flavonoid nobiletin exhibits differential effects on cell viability in keratinocytes exposed to UVA versus UVB radiation

Cvammen, W.; Kemp, M. G.

10.1101/2022.01.21.476505 — pharmacology and toxicology — Posted on 2022-01-23

1213 Large-scale systematic feasibility study on the pan-cancer predictability of multi-omic biomarkers from whole slide images with deep learning

Arslan, S.; Mehrotra, D.; Schmidt, J.; Geraldes, A.; Singhal, S.; Hense, J.; Li, X.; Bass, C.; Raharja-Liu, P.

10.1101/2022.01.21.477189 — cancer biology — Posted on 2022-01-23

1214 NELL-1 regulates the matrisome to alter osteosarcoma disease progression

Qin, Q.; Gomez-Salazar, M.; Tower, R. J.; Chang, L.; Morris, C. D.; McCarthy, E. F.; Ting, K.; Zhang, X.; James, A. W.

10.1101/2022.01.21.477245 — cancer biology — Posted on 2022-01-23

1215 SHARPIN serine 146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion, and metastasis

Butt, U.; Khan, M. H.; Pouwels, J.; Westermarck, J.

10.1101/2022.01.21.477220 — cancer biology — Posted on 2022-01-23

1216 Benchmark of Differential Gene Expression Analysis Methods for Inter-species RNA-Seq Data using a Phylogenetic Simulation Framework

Bastide, P.; Soneson, C.; Lespinet, O.; Gallopin, M.

10.1101/2022.01.21.476612 — bioinformatics — Posted on 2022-01-23

1217 Effects of Neonicotinoid Seed Treatments on Soil Microbial Gene Expression Vary with Time in an Agricultural Ecosystem

Parizadeh, M.; Mimee, B.; W. Kembel, S.

10.1101/2022.01.20.477174 — genomics — Posted on 2022-01-23

1218 Widespread transposon co-option in the Caenorhabditis germline regulatory network

Carelli, F. N.; Cerrato, C.; Dong, Y.; Appert, A.; Dernburg, A.; Ahringer, J.

10.1101/2022.01.21.477252 — genomics — Posted on 2022-01-23

1219 Tropical origin, global diversification and dispersal in the pond damselflies (Coenagrionoidea) revealed by a new molecular phylogeny

Willink, B.; Ware, J.; Svensson, E. I.

10.1101/2022.01.21.477207 — evolutionary biology — Posted on 2022-01-23

1220 Bee core venom genes predominantly originated before aculeate stingers evolved

Koludarov, I.; Velasque, M.; Timm, T.; Lochnit, G.; Heinzinger, M.; Vilcinskas, A.; Gloag, R.; Harpur, B. A.; Podsiadlowski, L.; Rost, B.; Dutertre, S.; Stolle, E.; von Reumont, B. M.

10.1101/2022.01.21.477203 — evolutionary biology — Posted on 2022-01-23

1221 Delimiting the cryptic diversity and host preferences of Sycophila parasitoid wasps associated with oak galls using phylogenomic data

Zhang, Y. M.; Sheikh, S.; Ward, A. K. G.; Forbes, A. A.; Prior, K.; Stone, G. N.; Gates, M.; Egan, S.; Zhang, L. N.; Davis, C.; Weinersmith, K.; Melika, G.; Lucky, A.

10.1101/2022.01.21.477213 — evolutionary biology — Posted on 2022-01-23

1222 Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in Drosophila suzukii and its related species

Tanaka, K. M.; Takahashi, K.; Rice, G. R.; Rebeiz, M.; Kamimura, Y.; Takahashi, A.

10.1101/2022.01.21.477200 — developmental biology — Posted on 2022-01-23

1223 On the hormonal control of posterior regeneration in the annelid Platynereis dumerilii

Alvarez-Campos, P.; Planques, A.; Bideau, L.; Vervoort, M.; Gazave, E.

10.1101/2022.01.21.477205 — developmental biology — Posted on 2022-01-23

1224 The architecture of the actin network can balance the pushing forces produced by growing microtubules.

Yamamoto, S.; Gaillard, J.; Vianay, B.; Guerin, C.; Orhant-Prioux, M.; Blanchoin, L.; Thery, M.

10.1101/2022.01.21.476947 — cell biology — Posted on 2022-01-23

1225 A survey of neurophysiological differentiation across mouse visual brain areas and timescales

Gandhi, S. R.; Mayner, W. G. P.; Marshall, W.; Billeh, Y. N.; Bennett, C.; Gale, S.; Mochizuki, C.; Siegle, J. H.; Olsen, S. R.; Tononi, G.; Koch, C.; Arkhipov, A.

10.1101/2022.01.21.476869 — neuroscience — Posted on 2022-01-23

1226 Genetic control of neuronal activity enhances axonal growth only on permissive substrates

Mesquida-Veny, F.; Martinez-Torres, S.; del Rio, J. A.; Hervera Abad, A.

10.1101/2022.01.21.477184 — neuroscience — Posted on 2022-01-23

1227 Population dynamics of epithelial-mesenchymal heterogeneity in cancer cells

Jain, P.; Bhatia, S.; Thompson, E. W.; Jolly, M. K.

10.1101/2022.01.21.475826 — systems biology — Posted on 2022-01-23

1228 Multivalent binding proteins can drive collapse and reswelling of chromatin in confinement

Guha, S.; Mitra, M. K.

10.1101/2022.01.21.477199 — biophysics — Posted on 2022-01-23

1229 Transcriptome-wide Association Study and eQTL colocalization identify potentially causal genes responsible for bone mineral density GWAS associations

Al-Barghouthi, B. M.; Rosenow, W. T.; Du, K.-P.; Heo, J.; Maynard, R.; Mesner, L.; Calabrese, G.; Nakasone, A.; Senwar, B.; Gerstenfeld, L.; Ferguson, V.; Ackert-Bicknell, C.; Morgan, E.; Brautigan, D. L.; Farber, C. R.

10.1101/2021.10.12.464046 — genomics — Posted on 2022-01-23

1230 Human genetic variations reveal Chromosomal Instability aiding Variants (CIVa) in kinetochore-microtubule associated proteins

Draviam, V. M.; Islam, A.; Manjarrez-Gonzalez, J. C.; Gore, T.; Song, X.

10.1101/2022.01.22.477339 — cell biology — Posted on 2022-01-23

1231 CRISPR-based targeted haplotype-resolved assemblies of a megabase region

Li, T.; Du, D.; Zhang, D.; Ma, J.; Zhou, M.; Meng, W.; Jin, Z.; Lin, Y.; Chen, Z.; Yuan, H.; Wang, J.; Dong, S.; Sun, S.; Ye, W.; Li, B.; Zhang, Z.; Xie, Z.; Qiu, W.; Liu, Y.

10.1101/2022.01.21.477044 — genomics — Posted on 2022-01-23

1232 EFA6R suppresses ovarian cancer cell migration and invasion

Tamaddon-Jahromi, S.; Murphy, K.; Walker, W.; Kanamarlapudi, V.

10.1101/2022.01.21.477266 — cell biology — Posted on 2022-01-23

1233 Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus

Beam, J. E.; Wagner, N. J.; Lu, K.-Y.; Rowe, S. E.; Conlon, B. P.

10.1101/2022.01.22.477360 — microbiology — Posted on 2022-01-23

1234 Novel orthonairovirus in rodents and shrews, Gabon

Ozeki, T.; Abe, H.; Ushijima, Y.; Nze-Nkogue, C.; Akomo-Okoue, E. F.; Ella, G. W. E.; Koumba, L. B. M.; Nso, B. C. B. B.; Mintsa-Nguema, R.; Makouloutoou-Nzassi, P.; Makanga, B. K.; Nguelet, F. L. M.; Ondo, G. N.; Mbadinga, M. J. V. M.; Igasaki, Y.; Okada, S.; Lell, B.; Bonney, L. C.; Hewson, R.; Kurosaki, Y.; Yasuda, J.

10.1101/2022.01.22.477371 — microbiology — Posted on 2022-01-23

1235 FOXO dictates initiation of B cell development and myeloid restriction in common lymphoid progenitors

Pena-Perez, L.; Kharazi, S.; Frengen, N.; Krstic, A.; Bouderlique, T.; Hauenstein, J.; He, M.; Somuncular, E.; Li Wang, X.; Dahlberg, C.; Gustafsson, C.; Johansson, A.-S.; Walfridsson, J.; Kadri, N.; Woll, P. S.; Kierczak, M.; Qian, H.; Westerberg, L.; Luc, S.; Mansson, R.

10.1101/2022.01.21.477216 — immunology — Posted on 2022-01-23

1236 Chromatin reprogramming and transcriptional regulation orchestrate embryogenesis in hexaploid wheat

Zhao, L.; Lin, X.; Yang, Y.; Bie, X.; Zhang, H.; Chen, J.; Liu, X.; Wang, H.; Jiang, J.; Fu, X.; Zhang, X.; Xiao, J.

10.1101/2022.01.21.477188 — plant biology — Posted on 2022-01-23

1237 Impact of neonatal activation of nuclear receptor CAR (Nr1i3) on Cyp2 gene expression in adult mouse liver

Shin, A.; Waxman, D. J.

10.1101/2022.01.21.477223 — pharmacology and toxicology — Posted on 2022-01-23

1238 Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing

Truong, D. D.; Lamhamedi-Cherradi, S.-E.; Porter, R. W.; Krishnan, S.; Swaminathan, J.; Gibson, A. L.; Lazar, A. J.; Livingston, J. A.; Gopalakrishnan, V.; Gordon, N.; Daw, N. C.; Gorlick, R.; Ludwig, J. A.

10.1101/2022.01.21.476982 — cancer biology — Posted on 2022-01-22

1239 Structure and function of BcpE2, the most promiscuous GH3-family beta-glucosidase for scavenging glucose from heterosides

Deflandre, B.; Jadot, C.; Planckaert, S.; Thiebaut, N.; Stulanovic, N.; Herman, R.; Devreese, B.; Kerff, F.; Rigali, S.

10.1101/2022.01.22.477351 — biochemistry — Posted on 2022-01-23

1240 Pharmacological inhibition of HDAC6 downregulates TGF-β via Smad2/3 acetylation and improves dystrophin-deficient muscles.

Osseni, A.; Ravel-Chapuis, A.; Scionti, I.; Gangloff, Y.-G.; Moncollin, V.; Mounier, R.; Leblanc, P.; Jasmin, B. J.; Schaeffer, L.

10.1101/2022.01.21.477182 — physiology — Posted on 2022-01-22

1241 Assessing Reproducibility of High-throughput Experiments in the Case of Missing Data.

Singh, R.; Zhang, F.; Li, Q.

10.1101/2021.07.10.451851 — bioinformatics — Posted on 2022-01-22

1242 Tunable Cellular Localization and Extensive Cytoskeleton-Interplay of Reflectins

Song, J.; Chuanyang, L.; Li, B.; Liu, L.; Zeng, L.; Ye, Z.; Wu, W.; Hu, B.

10.1101/2021.08.23.457345 — cell biology — Posted on 2022-01-22

1243 A Snapshot of the Global Drinking Water Virome: Diversity and Metabolic Potential Vary with Residual Disinfectant Use

Hegarty, B. E.; Dai, Z.; Raskin, L.; Pinto, A. J.; Wigginton, K.; Duhaime, M. B.

10.1101/2021.10.07.463401 — microbiology — Posted on 2022-01-22

1244 Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host directed antivirals.

Fang, J.; Pietzsch, C.; Witwit, H.; Tsaprailis, G.; Crynen, G.; Cho, K. F.; Ting, A. Y.; Bukreyev, A.; Saphire, E. O.; de la Torre, J. C.

10.1101/2021.07.16.452739 — microbiology — Posted on 2022-01-22

1245 Single-cell RNA-seq analysis reveals lung epithelial cell-specific contributions of Tet1 to allergic inflammation

Zhu, T.; Brown, A. P.; Cai, L.; Quon, G.; Ji, H.

10.1101/2021.12.22.473869 — immunology — Posted on 2022-01-22

1246 Mapping Spatial Frequency Preferences Across Human Primary Visual Cortex

Broderick, W. F.; Simoncelli, E. P.; Winawer, J.

10.1101/2021.09.27.462032 — neuroscience — Posted on 2022-01-22

1247 A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors

Rothweiler, E.; Stefaniak, J.; Ward, J.; Rogers, C.; Balikci, E.; Huber, K. V. M.

10.1101/2022.01.20.477145 — systems biology — Posted on 2022-01-22

1248 Touch-triggered bZIP translocation regulates elongation and secondary wall biosynthesis

Coomey, J. H.; MacKinnon, K. J.-M.; McCahill, I. W.; Handakumbura, P.; Trabucco, G. M.; Mazzola, J.; Leblanc, N. A.; Kheam, R.; Hernandez-Romero, M.; Barry, K. W.; Liu, L.; Lee, J. E.; Vogel, J. P.; O'Malley, R.; Chambers, J. J.; Hazen, S. P.

10.1101/2021.02.03.429573 — plant biology — Posted on 2022-01-22

1249 Invadopodia enable cooperative invasion and metastasis of breast cancer cells

Perrin, L.; Belova, E.; Bayarmagnai, B.; Tuzel, E.; Gligorijevic, B.

10.1101/2021.02.13.431047 — cancer biology — Posted on 2022-01-22

1250 Outsourced hearing in an orb-weaving spider that uses its web as an auditory sensor

Zhou, J.; Lai, J.; Menda, G.; Stafstrom, J. A.; Miles, C. I.; Hoy, R. R.; Miles, R. N.

10.1101/2021.10.17.464740 — animal behavior and cognition — Posted on 2022-01-22

1251 Once-daily feeding is associated with better health in companion dogs: Results from the Dog Aging Project

Bray, E. E.; Zheng, Z.; Tolbert, M. K.; McCoy, B. M.; Dog Aging Project Consortium, ; Kaeberlein, M.; Kerr, K. F.

10.1101/2021.11.08.467616 — animal behavior and cognition — Posted on 2022-01-22

1252 Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states

Rodriguez-Algarra, F.; Danson, A.; Seaborne, R.; Ylidizoglu, S.; Yoshikawa, H.; Law, P.; Ahmad, Z.; Maudsley, V.; Brew, A.; Holmes, N.; Ochoa, M.; Hodgkinson, A.; Marzi, S.; Madapura, P.; Loose, M. W.; Holland, M.; Rakyan, V.

10.1101/2021.06.10.447887 — genomics — Posted on 2022-01-22

1253 Heterosis counteracts hybrid breakdown to forestall speciation by parallel natural selection

Thompson, K. A.; Schluter, D.

10.1101/2022.01.20.477157 — evolutionary biology — Posted on 2022-01-22

1254 Spatial phylogenetics of Japanese ferns: Patterns, processes, and implications for conservation

Nitta, J.; Mishler, B. D.; Iwasaki, W.; Ebihara, A.

10.1101/2021.08.26.457744 — evolutionary biology — Posted on 2022-01-22

1255 Spatial regulation of the anaphase-promoting complex/cyclosome by a microtubule adaptor

Cao, X.; Shami Shah, A.; Sanford, E. J.; Smolka, M. B.; Baskin, J. M.

10.1101/2022.01.04.474939 — cell biology — Posted on 2022-01-22

1256 Mast cell-mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi

Weimershaus, M.; Carvalho, C.; Enee, E.; Rignault, R.; Dussiot, M.; van Endert, P.; Maciel, T. T.; Hermine, O.

10.1101/2022.01.21.477149 — immunology — Posted on 2022-01-22

1257 An early decline in ETPs reflects reduced pre-thymic progenitors and altered signals from the thymus microenvironment

Srinivasan, J.; Vasudev, A.; Selden, H. J.; Perez, E.; LaFleur, B. J.; Sinari, S. A.; Krueger, A.; Richie, E. R.; Ehrlich, L. I. R.

10.1101/2022.01.18.476832 — immunology — Posted on 2022-01-22

1258 Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.

Sabate-Soler, S.; Nickels, S. L.; Saraiva, C.; Berger, E.; Dubonyte, U.; Barmpa, K.; Lan, Y. J.; Kouno, T.; Jarazo, J.; Robertson, G.; Sharif, J.; Koseki, H.; Thome, C.; Shin, J. W.; Cowley, S. A.; Schwamborn, J. C.

10.1101/2022.01.21.477192 — neuroscience — Posted on 2022-01-22

1259 EEG-Based Spectral Analysis ShowingBrainwave Changes Related to ModulatingProgressive Fatigue During a ProlongedIntermittent Motor Task

Suviseshamuthu, E. S.; Shenoy Handiru, V.; Allexandre, D.; Hoxha, A.; Saleh, S.; Yue, G. H.

10.1101/2021.09.08.458591 — neuroscience — Posted on 2022-01-22

1260 Iron Deficiency Induces Heart Failure with Ectopic Cardiac Calcification in Mice with Metabolic Syndrome

Naito, Y.; Sawada, H.; Yasumura, S.; Horimatsu, T.; Okuno, K.; Tahara, S.; Nishimura, K.; Asakura, M.; Tsujino, T.; Masuyama, T.; Ishihara, M.

10.1101/2022.01.20.477010 — pathology — Posted on 2022-01-22

1261 scFeatures: Multi-view representations of single-cell and spatial data for disease outcome prediction

Cao, Y.; Lin, Y.; Patrick, E.; Yang, P.; Yang, J. Y. H.

10.1101/2022.01.20.476845 — bioinformatics — Posted on 2022-01-22

1262 Found in translation: Microproteins are a new class of potential host cell impurity in mAb drug products

Castro-Rivadeneyra, M.; Tzani, I.; Kelly, P.; Strasser, L.; Guapo, F.; Tierney, C.; Zhang, L.; Clynes, M.; Karger, B. L.; Barron, N.; Bones, J.; Clarke, C.

10.1101/2022.01.20.475618 — genomics — Posted on 2022-01-22

1263 Butterfly wings exhibit spatial variation in chromatin accessibility

Connahs, H.; Gupta, M. d.; Monteiro, A.

10.1101/2022.01.21.477190 — genomics — Posted on 2022-01-22

1264 A monotone single index model for missing-at-random longitudinal proportion data

Acharyya, S.; Pati, D.; Bandyopadhyay, D.; Sun, S.

10.1101/2022.01.20.477170 — developmental biology — Posted on 2022-01-22

1265 Hsa-miR-31-5p controls a metabolic switch in psoriatic keratinocytes that identifies therapeutic intervention

Wang, M.; Yong, Y.; Vos, H.; Gulersonmez, M. C.; Stigter, E. C. A.; Gerrits, J.; Pages Gallego, M.; van Es, R.; Li, L.; Deng, H.; Han, L.; Huang, R.; Lu, C.; Burgering, B. M.

10.1101/2022.01.21.477183 — immunology — Posted on 2022-01-22

1266 A snapshot of brain and cognition in healthy mid-life and older adults

Borne, L.; Lupton, M. K.; Guo, C.; Mosley, P.; Adam, R.; Ceslis, A.; Bourgeat, P.; Fazlollahi, A.; Maruff, P.; Rowe, C. C.; Masters, C. L.; Fripp, J.; Robinson, G. A.; Breakspear, M.; the Prospective Imaging Study of Ageing, ; the Australian Imaging Biomarkers and Lifestyle flagship study of ageing, ; the Alzheimer's Disease Neuroimaging Initiative,

10.1101/2022.01.20.476706 — neuroscience — Posted on 2022-01-22

1267 Characterizing Variability of Audiovisual Speech Perception Based on Periodic and Aperiodic Features of Prestimulus Brain Activity

Singh, V. A. V.; Kumar, V. G.; Banerjee, A.; Roy, D.

10.1101/2022.01.20.477172 — neuroscience — Posted on 2022-01-22

1268 Wildlife and Marine Mammal Spatial Observatory: Observation and automated detection of Southern Right Whales in multispectral satellite imagery

Houegnigan, L.; Romero Merino, E.; Vermeulen, E.; Block, J.; Safari, P.; Moreno-Noguer, F.; Nadeu, C.

10.1101/2022.01.20.477141 — bioinformatics — Posted on 2022-01-22

1269 Prospective Motion Correction and Automatic Segmentation of Penetrating Arteries in Phase Contrast MRI at 7 T

Moore, J.; Jimenez, J.; Lin, W.; Powers, W.; Zong, X.

10.1101/2022.01.20.477093 — bioengineering — Posted on 2022-01-22

1270 Multiscale computer modeling of spreading depolarization in brain slices

Kelley, C.; Newton, A. J. H.; Hrabetova, S.; McDougal, R. A.; Lytton, W. W.

10.1101/2022.01.20.477118 — neuroscience — Posted on 2022-01-22

1271 The Retinal Basis of Photoaversion in Neonatal Mice

Caval-Holme, F.; Aranda, M.; Quaen Chen, A.; Tiriac, A.; Zhang, Y.; Smith, B.; Birnbaumer, L.; Schmidt, T. M.; Feller, M.

10.1101/2022.01.20.477130 — neuroscience — Posted on 2022-01-22

1272 The Intestine is a Major Contributor to Circulating TCA Cycle Intermediates in Mice

Tong, W.; Hannou, S. A.; Wang, Y.; Astapova, I.; Sargsyan, A.; Monn, R.; Thiriveedi, V.; Li, D.; McCann, J. R.; Rawls, J. F.; Roper, J.; Zhang, G.-F.; Herman, M. A.

10.1101/2022.01.20.477123 — physiology — Posted on 2022-01-22

1273 Single cell genotyping of matched bone marrow and peripheral blood cells in treatment naive and AZA-treated MDS and CMML

Schnegg-Kaufmann, A.; Thoms, J. A. I.; Bhuyan, G. S.; Hampton, H. R.; Vaughan, L.; Rutherford, K.; Kakadia, P. M.; Johansson, E. M. V.; Failes, T.; Arndt, G. M.; Koval, J.; Lindeman, R.; Warbuton, P.; Rodriguez-Meira, A.; Mead, A. J.; Unnikrishnan, A.; Bohlander, S. K.; Papaemmanuil, E.; Faridani, O.; Jolly, C. J.; Zanini, F.; Pimanda, J. E.

10.1101/2022.01.20.476890 — cancer biology — Posted on 2022-01-22

1274 GGDB: A Grameneae Genome Alignment Database of Homologous Genes Hierarchically Related to Evolutionary Events

Yang, Q.; Liu, T.; Wu, T.; Lei, T.; Li, Y.; Wang, X.

10.1101/2022.01.20.477137 — bioinformatics — Posted on 2022-01-22

1275 Predicting evolution in experimental range expansions of an aquatic model system

Zilio, G.; Krenek, S.; Gougat-Barbera, C.; Fronhofer, E. A.; Kaltz, O.

10.1101/2022.01.20.477128 — evolutionary biology — Posted on 2022-01-22

1276 Bacteria-mediated stabilization of murine norovirus

Budicini, M. R.; Pfeiffer, J. K.

10.1101/2022.01.21.477311 — microbiology — Posted on 2022-01-22

1277 The Androgen Receptor: A Therapeutic Target in Desmoplastic Small Round Cell Sarcoma

Lamhamedi-Cherradi, S.-E.; Maitituoheti, M.; Menegaz, B. A.; Krishnan, S.; Vetter, A. M.; Camacho, P.; Wu, C.-C.; Beird, H. C.; Porter, R. W.; Ingram, D. R.; Ramamoorthy, V.; Mohiuddin, S.; McCall, D.; Truong, D. D.; Cuglievan, B.; Futreal, P. A.; Velasco, A. R.; Anvar, N. E.; Utama, B.; Titus, M.; Lazar, A. J.; Wang, W.-L.; Rodriguez-Aguayo, C.; Ratan, R.; Livingston, J. A.; Rai, K.; MacLeod, A. R.; Daw, N. C.; Hayes-Jordan, A.; Ludwig, J. A.

10.1101/2022.01.20.477146 — cancer biology — Posted on 2022-01-22

1278 Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

Grout, J. A.; Sirven, P.; Leader, A. M.; Maskey, S.; Hector, E.; Puisieux, I.; Steffan, F.; Cheng, E.; Tung, N.; Maurin, M.; Vaineau, R.; Karpf, L.; Plaud, M.; Casanova-Acebes, M.; Tabachnikova, A.; Keerthivasan, S.; Lansky, A.; LeBerichel, J.; Walker, L.; Rahman, A. H.; Gnjatic, S.; Adam, J.; Martin, J. C.; Wolf, A.; Flores, R.; Beasley, M. B.; Pradhan, R.; Müller, S.; Marron, T. U.; Turley, S. J.; Merad, M.; Kenigsberg, E.; Salmon, H.

10.1101/2022.01.20.476763 — cancer biology — Posted on 2022-01-22

1279 Overestimated Polygenic Prediction due to Overlapping Subjects in Genetic Datasets

Park, D. K.; Chen, M.; Kim, S.; Joo, Y. Y.; Loving, R.; Kim, H.-S.; Cha, J.; Yoo, S.; Kim, J. H.

10.1101/2022.01.19.476997 — genomics — Posted on 2022-01-22

1280 Metatranscriptomics reveals a shift in microbial community composition and function during summer months in a coastal marine environment

Sutherland, B. J. G.; Finke, J. F.; Saunders, R.; Warne, S.; Schulze, A. D.; Strohm, J. H. T.; Chan, A. M.; Suttle, C. A.; Miller, K. M.

10.1101/2022.01.21.477286 — genetics — Posted on 2022-01-22

1281 IL-21 lowers the B cell receptor affinity threshold for participation in a T cell dependent immune response.

Dvorscek, A. R.; McKenzie, C. I.; Robinson, M. J.; Ding, Z.; Pitt, C.; O'Donnell, K.; Zotos, D.; Brink, R.; Tarlinton, D. M.; Quast, I.

10.1101/2022.01.21.476732 — immunology — Posted on 2022-01-22

1282 Macrophage activation of cGAS and TRIM5 distinguish pandemic and non-pandemic HIV

Zuliani-Alvarez, L.; Larsen, M.; Rasaiyaah, J.; Monit, C.; Perry, S. O.; Sumner, R.; McAlpine-Scott, S.; Dickson, C.; Rifat Faysal, K. M.; Hilditch, L.; Miles, R.; Bibollet-Ruche, F.; Hahn, B. H.; Bocking, T.; Pinotsis, N.; James, L. C.; Jacques, D.; Towers, G. J.

10.1101/2022.01.21.477263 — immunology — Posted on 2022-01-22

1283 Virus-assisted directed evolution of enhanced suppressor tRNAs in mammalian cells

Kelemen, R.; Jewel, D.; Huang, R.; Zhu, Z.; Cao, X.; Pasha, M.; Anthony, J.; van Opijnen, T.; Chatterjee, A.

10.1101/2022.01.21.477302 — synthetic biology — Posted on 2022-01-22

1284 Pairwise and higher-order epistatic effects among somatic cancer mutations across oncogenesis

Alfaro-Murillo, J. A.; Townsend, J. P.

10.1101/2022.01.20.477132 — cancer biology — Posted on 2022-01-22

1285 Development and characterization of a human arteriovenous malformation (AVM)-on-a-chip model

Soon, K.; Li, M.; Wu, R.; Fish, J. E.; Nunes, S. S.

10.1101/2022.01.20.477166 — bioengineering — Posted on 2022-01-22

1286 VCF2Prot: An Efficient and Parallel Tool for Generating Personalized Proteomes from VCF Files

ElAbd, H.; Degenhardt, F.; Lenz, T. L.; Franke, A.; Wendorff, M.

10.1101/2022.01.21.477084 — genomics — Posted on 2022-01-22

1287 ESCPE-1 Mediates Retrograde Endosomal Sorting of the SARS-CoV-2 Host Factor Neuropilin-1

Simonetti, B.; Daly, J. L.; Simon-Gracia, L.; Klein, K.; Weeratunga, S.; Anton-Plagaro, C.; Tobi, A.; Hodgson, L.; Lewis, P.; Heesom, K. J.; Shoemark, D. K.; Davidson, A. D.; Collins, B. M.; Teesalu, T.; Yamauchi, Y.; Cullen, P. J.

10.1101/2022.01.20.477115 — cell biology — Posted on 2022-01-22

1288 A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis

Shi, J.; Wu, X.; Wang, Z.; Li, F.; Meng, Y.; Moore, R. M.; Cui, J.; Xue, C.; Croce, K. R.; Yurdagul, A.; Doench, J. G.; Li, W.; Zarbalis, K. S.; Tabas, I.; Yamamoto, A.; Zhang, H.

10.1101/2022.01.21.477299 — cell biology — Posted on 2022-01-22

1289 Structural basis for Parkinson's Disease-linked LRRK2's binding to microtubules

Snead, D. M.; Matyszewski, M.; Dickey, A. M.; Lin, Y. X.; Leschziner, A. E.; Reck-Peterson, S. L.

10.1101/2022.01.21.477284 — cell biology — Posted on 2022-01-22

1290 GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance

Chen, W.; Brown, J. S.; He, T.; Wu, W.-S.; Tu, S.; Weng, Z.; Zhang, D.; Lee, H.-C.

10.1101/2022.01.21.477267 — cell biology — Posted on 2022-01-22

1291 Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors

Duan, J.; Shen, D.-D.; Zhao, T.; Guo, S.; He, X.; Yin, W.; Xu, P.; Ji, Y.; Chen, L.-N.; Liu, J.; Zhang, H.; Liu, Q.; Shi, Y.; Cheng, X.; Jiang, H.; Xu, H. E.; Zhang, Y.; Xie, X.; Jiang, Y.

10.1101/2022.01.22.477336 — molecular biology — Posted on 2022-01-22

1292 Neutralization of Omicron SARS-CoV-2 by 2 or 3 doses of BNT162b2 vaccine

Xia, H.; Zou, J.; Kurhade, C.; Cai, H.; Yang, Q.; Cutler, M.; Cooper, D.; Muik, A.; Jansen, K. U.; Xie, X.; Swanson, K. A.; Shi, P.-Y.

10.1101/2022.01.21.476344 — microbiology — Posted on 2022-01-22

1293 Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation

Page, J. E.; Skiba, M. A.; Do, T.; Kruse, A. C.; Walker, S.

10.1101/2022.01.21.477235 — microbiology — Posted on 2022-01-22

1294 Broadly-recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles

Becerra-Artiles, A.; Calvo-Calle, J. M.; Co, M.; Nanaware, P.; Cruz, J.; Weaver, G. C.; Lu, L.; Forcini, C.; Finberg, R. W.; Moormann, A.; Stern, L. J.

10.1101/2022.01.20.477107 — immunology — Posted on 2022-01-22

1295 Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis

Bai, X.; Verma, D.; Garcia, C.; Musheyev, A.; Kim, K.; Fornis, L.; Griffith, D.; Li, L.; Whittel, N.; Gadwa, J.; Ohanjanyan, T.; Ordway, D.; Chan, E.

10.1101/2022.01.20.477097 — immunology — Posted on 2022-01-22

1296 Rapid prototyping of metabolites detection by bacterial biosensors in human fecal samples.

Zuniga, A.; Boivineau, L.; Mayonove, P.; Conejero, I.; Pageaux, G.-P.; Altwegg, R.; Bonnet, J.

10.1101/2022.01.21.476945 — synthetic biology — Posted on 2022-01-22

1297 In Silico Analysis Of The Effects Of Omicron Spike Amino Acid Changes On The Interactions With Human ACE2 Receptor And Structurally Characterized Complexes With Human Antibodies

D'Arminio, N.; Giordano, D.; Scafuri, B.; Biancaniello, C.; Petrillo, M.; Facchiano, A.; Marabotti, A.

10.1101/2022.01.20.477105 — bioinformatics — Posted on 2022-01-22

1298 Comprehensive Evaluation of ACE2-Fc Combination with Neutralization Antibody on Broad Protection against SARS-CoV-2 and Its Variants

Tang, H.; Ke, Y.; Ma, H.; Han, L.; Wang, L.; Zong, H.; Yuan, Y.; Wang, Z.; He, Y.; Chang, Y.; Wang, S.; Liu, J.; Yue, Y.; Xu, W.; Zhang, X.; Wang, Z.; Yang, L.; Chen, H.; Bian, Y.; Zhang, B.; Liao, Y.; Yin, H.; Chen, Y.; Zhang, E.; Zhang, X.; Jiang, H.; Xie, Y.; Gilly, J.; Wu, M.; Sun, T.; Zhu, J.

10.1101/2022.01.17.475291 — cell biology — Posted on 2022-01-22

1299 Mutations in TIC100 impair and repair chloroplast protein import and impact retrograde signalling

Loudya, N.; Maffei, D. P. F.; Bedard, J.; Ali, S. M.; Devlin, P. F.; Jarvis, P.; Lopez-Juez, E.

10.1101/2022.01.18.476798 — plant biology — Posted on 2022-01-22

1300 A new demethylase gene OsDML4 involved in high temperature induced floury endosperm formation in rice

Yan, Y.; Li, C.; Liu, Z.; Zhuang, J.-J.; Kong, J.-R.; Yang, Z.-K.; Yu, J.; Alam, M. S.; Ruan, C.-C.; Zhang, H.-M.; Xu, J.-H.

10.1101/2022.01.20.477110 — plant biology — Posted on 2022-01-22

1301 Actin networks modulate heterogenous NF-κB dynamics in response to TNFα

Butera, F.; Sero, J. E.; Dent, L. G.; Bakal, C.

10.1101/2022.01.19.476961 — cancer biology — Posted on 2022-01-22

1302 Triplet kinase-phosphatase targeting to overcome kinase inhibitor tolerance in brain tumor cells

Denisova, O.; Merisaari, J.; Huhtaniemi, R.; Qiao, X.; Yetukuri, L.; Jumppanen, M.; Kaur, A.; Paakkonen, M.; von Schantz-Fant, C.; Ohlmeyer, M.; Wennerberg, K.; Kauko, O.; Koch, R.; Aittokallio, T.; Taipale, M.; Westermarck, J.

10.1101/2022.01.20.477108 — cancer biology — Posted on 2022-01-22

1303 Image-centric compression of protein structures improves space savings

Staniscia, L.; Yu, Y. W.

10.1101/2022.01.20.477098 — bioinformatics — Posted on 2022-01-22

1304 Comparison of Two Individual Identification Algorithms for Snow Leopards (Panthera uncia) after Automated Detection

Blount, D.; Bohnett, E. T.; Holmberg, J. T.; Parham, J.; Poya Faryabi, S.; An, L.; Ahmad, B.; Khan, W.; Ostrowski, S.

10.1101/2022.01.20.477059 — bioinformatics — Posted on 2022-01-22

1305 Interaction of surface topography and taper mismatch on head-stem modular junction contact mechanics during assembly in modern total hip replacement

Gustafson, J. A.; Mell, S. P.; Levine, B.; Pourzal, R.; Lundberg, H. J.

10.1101/2022.01.20.476985 — bioengineering — Posted on 2022-01-22

1306 Poison frog dietary preference depends on prey type and alkaloid load

Moskowitz, N. A.; D'Agui, R.; O'Connell, L. A.

10.1101/2022.01.20.476996 — animal behavior and cognition — Posted on 2022-01-22

1307 Additive genetic effects in interacting species jointly determine the outcome of caterpillar herbivory

Gompert, Z.; Saley, T.; Philbin, C.; Yoon, S.; Perry, E.; Sneck, M. E.; Harrison, J. G.; Buerkle, A. C.; Fordyce, J. A.; Nice, C. C.; Dodson, C.; Lebeis, S. L.; Lucas, L. K.; Forister, M. L.

10.1101/2022.01.20.476992 — genomics — Posted on 2022-01-22

1308 Palatal morphology predicts the paleobiology of early salamanders

Jia, J.; Li, G.; Gao, K.-Q.

10.1101/2022.01.17.476642 — evolutionary biology — Posted on 2022-01-22

1309 Evolution of Daphnia population dynamics following invasion by a non-native predator

Einum, S.; Ullern, E. R.; Walsh, M.; Burton, T.

10.1101/2022.01.20.477096 — evolutionary biology — Posted on 2022-01-22

1310 Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

Guan, Y.; Chen, B.; Wu, Y.; Han, Z.; Xu, H.; Zhang, C.; Hao, W.; Gao, W.; Guo, Z.

10.1101/2022.01.11.475954 — molecular biology — Posted on 2022-01-22

1311 Core Transcription Programs Controlling Injury-Induced Neurodegeneration of Retinal Ganglion Cells

Tian, F.; Chen, Y.; Zhou, S.; Wang, Q.; Monavarfeshani, A.; Gao, K.; Jiang, W.; Kawaguchi, R.; Wang, Q.; Tang, M.; Donahue, R.; Meng, H.; Jacobi, A.; Yin, J.; Cai, X.; Hegarty, S.; Stanicka, J.; Dmitriev, P.; Taub, D.; Woolf, C. J.; Sanes, J.; Geschwind, D.; He, Z.

10.1101/2022.01.20.477004 — neuroscience — Posted on 2022-01-22

1312 In Vitro and In Vivo Pathogenicity of A. alternata to Sugar beet and Assessment of Sensitivity to Fungicides

Haque, M. E.; Parvin, M. S.

10.1101/2022.01.15.476474 — plant biology — Posted on 2022-01-22

1313 ECS1 and ECS2 regulate polyspermy and suppress the formation of haploid plants by promoting double fertilization

Mao, Y.; Nakel, T.; Erbasol Serbes, I.; Tekleyohans, D. G.; Joshi, S.; Baum, T.; Groß-Hardt, R.

10.1101/2022.01.20.476184 — plant biology — Posted on 2022-01-22

1314 Tonic GluD1 channel current is independent of G protein activity in the dorsal raphe nucleus

Copeland, D. S.; Gantz, S. C.

10.1101/2022.01.20.477055 — neuroscience — Posted on 2022-01-22

1315 Development and validation of Arc nanobodies: new tools for probing Arc dynamics and function

Ishizuka, Y.; Mergiya, T. F.; Baldinotti, R.; Xu, J.; Hallin, E. I.; Markusson, S.; Kursula, P.; Bramham, C. R.

10.1101/2022.01.20.477070 — neuroscience — Posted on 2022-01-22

1316 Genetic variation of human myokine signaling is dominated by biologic sex and sex hormones

Velez, L.; Van, C.; Moore, T.; Zhou, Z.; Johnson, C.; Hevener, A. L.; Seldin, M. M.

10.1101/2022.01.20.477045 — physiology — Posted on 2022-01-22

1317 Cytocapsular tube network-tumor system is an integrated physical target for the highly effective and efficient pharmacotherapy of solid cancers

Yi, T.; Wagner, G.

10.1101/2022.01.19.476991 — cancer biology — Posted on 2022-01-22

1318 Elucidating Collective Translocation of Nanoparticles Across the Skin Lipid Barrier: A Molecular Dynamics Study

Badhe, Y.; Sharma, P.; Gupta, R.; Rai, B.

10.1101/2022.01.20.477051 — biophysics — Posted on 2022-01-22

1319 Computational modeling of the evolutionary transition from C3 to C4 photosynthesis

Dadras, A.; Marashi, S.-A.; Kavousi, K.; Banaei-Moghaddam, A. M.

10.1101/2022.01.20.477074 — bioinformatics — Posted on 2022-01-22

1320 Uncovering hidden assembly artifacts: when unitigs are not safe and bidirected graphs are not helpful

Rahman, A.; Medvedev, P.

10.1101/2022.01.20.477068 — bioinformatics — Posted on 2022-01-22

1321 Accurate self-assessment in 2D: protein contact map quality estimation by deep evolutionary reconciliation

Roche, R.; Bhattacharya, S.; Shuvo, M. H.; Bhattacharya, D.

10.1101/2022.01.20.477079 — bioinformatics — Posted on 2022-01-22

1322 Neural Collective Matrix Factorization for Integrated Analysis of Heterogeneous Biomedical Data

Mariappan, R.; Jayagopal, A.; Ho, Z. S.; Rajan, V.

10.1101/2022.01.20.477057 — bioinformatics — Posted on 2022-01-22

1323 Organ Scaffold Characterizations Using Intravital Microscopy

Corridon, P. R.; Khan, A.

10.1101/2022.01.20.477052 — bioengineering — Posted on 2022-01-22

1324 Understanding immune-driven brain aging by human brain organoid microphysiological analysis platform

Song, S.; Ao, Z.; Cai, H.; Li, X.; Miao, Y.; Wu, Z.; Krzesniak, J.; Gu, M.; Lee, L. P.; Guo, F.

10.1101/2022.01.19.476989 — bioengineering — Posted on 2022-01-22

1325 Automatically tracking feeding behavior in populations of foraging worms

Bonnard, E.; Liu, J.; Zjacic, N.; Alvarez, L.; Scholz, M.

10.1101/2022.01.20.477072 — animal behavior and cognition — Posted on 2022-01-22

1326 A quantitative, genome-wide analysis in Drosophila reveals transposable elements' influence on gene expression is species-specific

Fablet, M.; Salcez-Ortiz, J.; Jacquet, A.; Menezes, B. F.; Dechaud, C.; Veber, P.; Nous, C.; Rebollo, R.; Vieira, C.

10.1101/2022.01.20.477049 — genomics — Posted on 2022-01-22

1327 Complex genetics cause and constrain fungal persistence in different parts of the mammalian body

Mullis, M. N.; Ghione, C.; Lough-Stevens, M.; Goldstein, I.; Matsui, T.; Levy, S. F.; Dean, M. D.; Ehrenreich, I.

10.1101/2022.01.20.477007 — genetics — Posted on 2022-01-22

1328 Trophic ecology of deep-sea megafauna in the ultra-oligotrophic Southeastern Mediterranean Sea

Guy-Haim, T.; Stern, N.; Sisma-Ventura, G.

10.1101/2022.01.20.477062 — ecology — Posted on 2022-01-22

1329 Parallels of quantum superposition in ecological models: from counterintuitive patterns to eco-evolutionary interpretations of cryptic species

Angeler, D.; Fried-Petersen, H.

10.1101/2022.01.20.477053 — ecology — Posted on 2022-01-22

1330 Brainstem somatostatin-expressing cells control the emotional regulation of pain behavior

Winke, N.; Aby, F.; Jercog, D.; Grivet, Z.; Girard, D.; Landry, M.; Castell, L.; Valjent, E.; Valerio, S.; Fossat, P.; Herry, C.

10.1101/2022.01.20.476899 — neuroscience — Posted on 2022-01-22

1331 Network architecture producing swing to stance transitions in an insect walking system

Strohmer, B.; Mantziaris, C.; Kynigopoulos, D.; Manoonpong, P.; Bonde Larsen, L.; Büschges, A.

10.1101/2022.01.20.477058 — neuroscience — Posted on 2022-01-22

1332 Sex differences in predictors and regional patterns of brain-age-gap estimates

Sanford, N.; Ge, R.; Antoniades, M.; Modabbernia, A.; Haas, S. S.; Whalley, H. C.; Galea, L.; Popescu, S. G.; Cole, J. H.; Frangou, S.

10.1101/2022.01.19.476964 — neuroscience — Posted on 2022-01-22

1333 A Population Response Model of Ensemble Coding

Utochkin, I. S.; Choi, J.; Chong, S. C.

10.1101/2022.01.19.476871 — neuroscience — Posted on 2022-01-22

1334 Selective activation of subthalamic nucleus output quantitatively scales movements

Friedman, A. D.; Yin, H.

10.1101/2022.01.19.477002 — neuroscience — Posted on 2022-01-22

1335 Characterization of second-order mixing effects in reconstructed cross-spectra of random neural fields

Hindriks, R.

10.1101/2022.01.19.476889 — neuroscience — Posted on 2022-01-22

1336 Wearing an Eye Mask During Overnight Sleep Improves Episodic Learning and Alertness

Greco, V.; Bergamo, D.; Cuoccio, P.; Konkoly, K. R.; Lombardo, K. M.; Lewis, P. A.

10.1101/2022.01.20.477083 — neuroscience — Posted on 2022-01-22

1337 Dopamine and ALK4 signaling synergize to induce PCBP1-mediated alternative splicing of FosB and sustained behavioral sensitization to cocaine

Krapacher, F. A.; Fernandez-Suarez, D.; Andersson, A.; Carrier-Ruiz, A.; Ibanez, C. F.

10.1101/2022.01.20.477040 — neuroscience — Posted on 2022-01-22

1338 Combined multiple transcriptional repression mechanisms generate ultrasensitivity and oscillations

Jeong, E. M.; Song, Y. M.; Kim, J. K.

10.1101/2022.01.19.476033 — systems biology — Posted on 2022-01-22

1339 Hyperglycemia in type 2 diabetes: physiological and clinical implications of a brain centered model.

Ojha, A.; Watve, M.

10.1101/2022.01.19.477014 — physiology — Posted on 2022-01-22

1340 Epigenetic anti-cancer treatment with a stabilized carbocyclic Decitabine analogue

Traube, F. R.; Bras, N. F.; Roos, W. P.; Sommermann, C. C.; Diehl, T.; Mayer, R. J.; Ofial, A. R.; Müller, M.; Zipse, H.; Carell, T.

10.1101/2022.01.19.476908 — cancer biology — Posted on 2022-01-22

1341 Endogenous 1-deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells

Cordes, T.; Kuna, R. S.; McGregor, G. H.; Khare, S. V.; Gengatharan, J.; Muthusamy, T.; Metallo, C. M.

10.1101/2022.01.19.476986 — cancer biology — Posted on 2022-01-22

1342 Framework for Denoising Monte Carlo Photon Transport Simulations Using Deep Learning

Raayai Ardakani, M.; Yu, L.; Kaeli, D. R.; Fang, Q.

10.1101/2022.01.19.477008 — biophysics — Posted on 2022-01-22

1343 Meta-analysis of Microbiome Association Networks Reveal Patterns of Dysbiosis in Diseased Microbiomes

Lam, T. J.; Ye, Y.

10.1101/2022.01.19.476958 — bioinformatics — Posted on 2022-01-22

1344 AbLang: An antibody language model for completing antibody sequences

Olsen, T. H.; Moal, I. H.; Deane, C. M.

10.1101/2022.01.20.477061 — bioinformatics — Posted on 2022-01-22

1345 mRNA expression explains metabolic and thermal physiology

Drown, M.; Crawford, D. L.; Oleksiak, M. F.

10.1101/2022.01.19.477029 — genetics — Posted on 2022-01-22

1346 Automated assessment reveals extinction risk of reptiles is widely underestimated across space and phylogeny

de Oliveira Caetano, G. H.; Chapple, D. G.; Grenyer, R.; Raz, T.; Rosenblatt, J.; Tingley, R.; Böhm, M.; Meiri, S.; Roll, U.

10.1101/2022.01.19.477028 — ecology — Posted on 2022-01-22

1347 Visualizing Synaptic Dopamine Efflux with a 2D Nanofilm

Bulumulla, C.; Krasley, A. T.; Walpita, D.; Beyene, A. G.

10.1101/2022.01.19.476937 — neuroscience — Posted on 2022-01-22

1348 XPD protects CTCF-Cohesin binding sites from somatic mutagenesis

Barbour, J. A.; Ou, T.; Fang, H.; Yue, N. C.; Zhu, X.; Wong-Brown, M.; Yang, H.; Wong, Y. T.; Bowden, N. A.; Wu, S.; Wong, J. W. H.

10.1101/2022.01.21.477237 — molecular biology — Posted on 2022-01-22

1349 Structure and Protein-Protein Interactions of Ice Nucleation Proteins Drive Their Activity

Hartmann, S.; Ling, M.; Dreyer, L. S. A.; Zipori, A.; Finster, K. W.; Grawe, S.; Jensen, L. Z.; Borck, S.; Reicher, N.; Drace, T.; Niedermeier, D.; Jones, N. C.; Hoffmann, S. V.; Wex, H.; Rudich, Y.; Boesen, T.; Santl-Temkiv, T.

10.1101/2022.01.21.477219 — microbiology — Posted on 2022-01-22

1350 Mutations in TIC100 impair and repair chloroplast protein import and impact retrograde signalling

Loudya, N.; Maffei, D. P. F.; Bedard, J.; Ali, S. M.; Devlin, P. F.; Jarvis, P.; Lopez-Juez, E.

10.1101/2022.01.18.476798 — plant biology — Posted on 2022-01-22

1351 Experimental evolution of Bacillus subtilis on Arabidopsis thaliana roots reveals fast adaptation and improved root colonization in the presence of soil microbes

Nordgaard, M.; Blake, C.; Maroti, G.; Hu, G.; Wang, Y.; Strube, M. L.; Kovacs, A. T.

10.1101/2021.07.09.451762 — microbiology — Posted on 2022-01-22

1352 Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke

Brunner, C.; Lagumersindez Denis, N.; Gertz, K.; Grillet, M.; Montaldo, G.; Endres, M.; Urban, A.

10.1101/2022.01.19.476904 — neuroscience — Posted on 2022-01-22

1353 Is the genomics cart before the restoration ecology horse? Insights from qualitative interviews and trends from the literature

Mohr, J. J.; Harrison, P. A.; Stanhope, J.; Breed, M. F.

10.1101/2021.08.05.455206 — scientific communication and education — Posted on 2022-01-22

1354 Morphological integration during postnatal ontogeny: implications for evolutionary biology

Hubbe, A.; Garcia, G.; Sebastiao, H.; Porto, A.; Machado, F. A.; Cheverud, J.; Marroig, G.

10.1101/2021.07.13.452198 — developmental biology — Posted on 2022-01-22

1355 Recruitment and organization of ESCRT-0 and ubiquitinated cargo via condensation

Banjade, S.; Zhu, L.; Jorgensen, J.; Suzuki, S.; Emr, S.

10.1101/2021.08.23.457352 — cell biology — Posted on 2022-01-22

1356 Meiotic DSB-independent role of protein phosphatase 4 in Hop1 assembly to promote meiotic chromosome axis formation in budding yeast

Shinohara, M.; Li, K.

10.1101/2021.05.10.443451 — molecular biology — Posted on 2022-01-22

1357 Staphylococcal protein A inhibits IgG-mediated phagocytosis by blocking the interaction of IgGs with FcγRs and FcRn

Cruz, A. R.; Bentlage, A. E. H.; Blonk, R.; Haas, C. J. C. d.; Aerts, P. C.; Scheepmaker, L. M.; Bouwmeester, I. G.; Lux, A.; Strijp, J. A. G. v.; Nimmerjahn, F.; Kessel, K. P. M. v.; Vidarsson, G.; Rooijakkers, S. H. M.

10.1101/2022.01.21.477287 — microbiology — Posted on 2022-01-22

1358 A new replication medium enables a rapid identification of {varphi}x-174 virus by synchronous fluorescence of Tryptophan.

Farber, Y.; Shlosberg, Y.; Schechter, I.; Armon, R.

10.1101/2021.11.27.470195 — microbiology — Posted on 2022-01-22

1359 The Goldilocks Principle conferred by LDH isoenzymes controls murine T cell glycolysis and differentiation

Chen, X.; Liu, L.; Wang, R.

10.1101/2022.01.21.477227 — immunology — Posted on 2022-01-22

1360 Lysophosphatidylcholine acyltransferase 2 (LPCAT2) Regulates The Expression of Macrophage Phenotype Markers in RAW264.7 Cells.

Poloamina, V. I.; Alrammah, H.; Abate, W.; Fejer, G.; Jackson, S. K.

10.1101/2021.11.25.469956 — immunology — Posted on 2022-01-22

1361 Measuring the double-drift illusion and its resets with hand trajectories

't Hart, B. M.; Henriques, D. Y. P.; Cavanagh, P.

10.1101/2021.08.06.455415 — neuroscience — Posted on 2022-01-22

1362 Controlling gene expression timing through gene regulatory architecture

Ali, M. Z.; Brewster, R. C.

10.1101/2021.04.09.439163 — systems biology — Posted on 2022-01-22

1363 The interplay of supercoiling and thymine dimers inDNA

Lim, W.; Randisi, F.; Doye, J. P. K.; Louis, A.

10.1101/2021.09.27.461905 — biophysics — Posted on 2022-01-22

1364 Glycosaminoglycans and glycoproteins influence the elastic response of synovial fluid nanofilms on model oxide surfaces

Mann, A. S.; Smith, A. M.; Saltzherr, J. O.; Gopinath, A.; Andresen Eguiluz, R. C.

10.1101/2021.11.19.469284 — biophysics — Posted on 2022-01-22

1365 A Binary Matrix Method to Enumerate, Hierarchically Order and Structurally Classify Peptide Aggregation

Tagad, A.; Singh, R. K.; Patwari, G. N.

10.1101/2021.11.29.470297 — biophysics — Posted on 2022-01-22

1366 Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumanniicomplex

Djahanschiri, B.; Di Venanzio, G.; Distel, J. S.; Breisch, J.; Dieckmann, M. A.; Goesmann, A.; Averhoff, B.; Göttig, S.; Wilharm, G.; Feldman, M. F.; Ebersberger, I.

10.1101/2022.01.10.475602 — genomics — Posted on 2022-01-22

1367 pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo

Rumley, J. D.; Preston, E. A.; Cook, D.; Peng, F. L.; Zacharias, A. L.; Wu, L.; Jileaeva, I.; Murray, J. I.

10.1101/2021.12.14.472681 — genetics — Posted on 2022-01-22

1368 Parallel evolution of amphioxus and vertebrate small-scale gene duplications

Braso-Vives, M.; Marletaz, F.; Echchiki, A.; Mantica, F.; Acemel, R. D.; Gomez-Skarmeta, J. L.; Targa, L. L.; Pontarotti, P.; Tena, J. J.; Maeso, I.; Escriva, H.; Irimia, M.; Robinson-Rechavi, M.

10.1101/2022.01.18.476203 — evolutionary biology — Posted on 2022-01-22

1369 Temperature-dependent genetics of thermotolerance between yeast species

Abrams, M. B.; Brem, R. B.

10.1101/2022.01.11.475859 — evolutionary biology — Posted on 2022-01-22

1370 Use of object detection in camera trap image identification: assessing a method to rapidly and accurately classify human and animal detections for research and application in recreation ecology

Fennell, M. J. E.; Beirne, C. W.; Burton, C.

10.1101/2022.01.14.476404 — ecology — Posted on 2022-01-22

1371 Pou5f3 and Sox19b determine gene expression repertoire at Zygotic Genome Activation

Gao, M.; Veil, M.; Rosenblatt, M.; Riesle, A. J.; Gebhard, A.; Hass, H.; Buryanova, L.; Yampolsky, L.; Gruening, B. A.; Ulianov, S. V.; Timmer, J.; Onichtchouk, D.

10.1101/2020.02.16.949362 — developmental biology — Posted on 2022-01-22

1372 A unified view of LCRs across species

Lee, B.; Jaberi-Lashkari, N.; Calo, E.

10.1101/2022.01.06.475253 — cell biology — Posted on 2022-01-22

1373 An atlas of plant full-length RNA reveals tissue-specific and evolutionarily-conserved regulation of poly(A) tail length

Jia, J.; Lu, W.; Liu, B.; Yu, Y.; Jin, X.; Shu, Y.; Long, Y.; Zhai, J.

10.1101/2022.01.21.477033 — molecular biology — Posted on 2022-01-22

1374 PopB-PcrV Interactions are Essential for Pore Formation in the Pseudomonas aeruginosa Type III Secretion System Translocon

Kundracik, E. C.; Trichka, J.; Diaz Aponte, J. E.; Rietsch, A.

10.1101/2022.01.21.477233 — microbiology — Posted on 2022-01-22

1375 Genomic screening of antimicrobial resistance markers in UK and US Campylobacter isolates highlights stability of resistance over an 18 year period

van Vliet, A. H. M.; Thakur, S.; Prada, J. M.; Mehat, J. W.; La Ragione, R.

10.1101/2021.08.24.457564 — microbiology — Posted on 2022-01-22

1376 Imbalance of Neuregulin1-ErbB2/3 signaling underlies altered myelin homeostasis in models of Charcot-Marie-Tooth disease type 4H

El-bazzal, L.; Ghata, A.; esteve, c.; Quintana, P.; Trevisiol, N.; Lembo, F.; Megarbane, A.; borg, J.-P.; nicolas, l.; Bartoli, M.; Poitelon, Y.; Roubertoux, P.; DELAGUE, V.; Bernard-Marissal, n.

10.1101/2022.01.20.477077 — neuroscience — Posted on 2022-01-22

1377 A self-supervised domain-general learning framework for human ventral stream representation

Konkle, T.; Alvarez, G. A.

10.1101/2020.06.15.153247 — neuroscience — Posted on 2022-01-22

1378 The Digital Brain Bank, an open access platform for post-mortem datasets

Tendler, B. C.; Hanayik, T.; Ansorge, O.; Bangerter-Christensen, S.; Berns, G. S.; Bertelsen, M. F.; Bryant, K. L.; Foxley, S.; van den Heuvel, M.; Howard, A. F. D.; Huszar, I.; Khrapitchev, A. A.; Leonte, A.; Manger, P. R.; Menke, R. A. L.; Mollink, J.; Mortimer, D.; Pallebage-Gamarallage, M.; Roumazeilles, L.; Sallet, J.; Scholtens, L. H.; Scott, C.; Smart, A.; Turner, M. R.; Wang, C.; Jbabdi, S.; Mars, R. B.; Miller, K. L.

10.1101/2021.06.21.449154 — neuroscience — Posted on 2022-01-22

1379 Hippocampal cells multiplex positive and negative engrams

Shpokayte, M.; McKissick, O.; Yuan, B.; Rahsepar, B.; Fernandez, F. R.; Ruesch, E. A.; Grella, S. L.; White, J. A.; Liu, X. S.; Ramirez, S.

10.1101/2020.12.11.419887 — neuroscience — Posted on 2022-01-22

1380 High efficiency multiplex biallelic heritable editing in Arabidopsis using an RNA virus

Nagalakshmi, U.; Meier, N.; Liu, J.-Y.; Voytas, D.; Dinesh-Kumar, S. P.

10.1101/2022.01.20.477144 — plant biology — Posted on 2022-01-22

1381 RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinoma

Srivastava, A.; Tommasi, C.; Sessions, D.; Mah, A.; Bencomo, T.; Garcia, J. M.; Jiang, T.; Lee, M.; Shen, J. Y.; Seow, L. W.; Nguyen, A.; Rajapakshe, K.; Coarfa, C.; Tsai, K. Y.; Lopez-Pajares, V.; Lee, C. S.

10.1101/2022.01.19.476979 — cancer biology — Posted on 2022-01-22

1382 XPD protects CTCF-Cohesin binding sites from somatic mutagenesis

Barbour, J. A.; Ou, T.; Fang, H.; Yue, N. C.; Zhu, X.; Wong-Brown, M.; Yang, H.; Wong, Y. T.; Wu, S.; Wong, J. W. H.

10.1101/2022.01.21.477237 — molecular biology — Posted on 2022-01-21

1383 Tissue-Specific Control of Ribosomal RNA Synthesis Revealed by Transcription Factor Profiling

Antony, C.; George, S. S.; Blum, J.; Somers, P.; Thorsheim, C. L.; Wu-Corts, D. J.; Ai, Y.; Gao, L.; Lv, K.; Tremblay, M. G.; Moss, T.; Tan, K.; Wilusz, J. E.; Ganley, A. R. D.; Pimkin, M.; Paralkar, V. R.

10.1101/2022.01.21.476118 — molecular biology — Posted on 2022-01-22

1384 CRISPR-Cas systems in Fusobacterium: An untapped genetic frontier

Umana, A.; Slade, D. J.

10.1101/2022.01.21.477265 — microbiology — Posted on 2022-01-21

1385 An in vitro neurogenetics platform for precision disease modeling in the mouse

CORTES, D. E.; ESCUDERO, M.; MITRA, A.; KORGAN, A. C.; EDWARDS, A.; O'CONNELL, K. M. S.; Reinholdt, L. G.; PERA, M. F.

10.1101/2022.01.21.477242 — neuroscience — Posted on 2022-01-21

1386 A proxy measure of striatal dopamine predicts individual differences in temporal precision.

Sadibolova, R.; Monaldi, L.; Terhune, D.

10.1101/2022.01.21.477273 — neuroscience — Posted on 2022-01-21

1387 The evolution of BDNF is defined by strict purifying selection and prodomain spatial coevolution, but what does it mean for human brain disease?

Lucaci, A. G.; Notaras, M.; Kosakovsky Pond, S. L.; Colak, D.

10.1101/2022.01.21.477254 — neuroscience — Posted on 2022-01-21

1388 Molecular and connectomic vulnerability shape cross-disorder cortical abnormalities

Hansen, J. Y.; Shafiei, G. Y.; Vogel, J. W.; Smart, K.; Bearden, C. E.; Hoogman, M.; Franke, B.; van Rooij, D.; Buitelaar, J.; McDonald, C. R.; Sisodiya, S.; Schmaal, L.; Veltman, D. J.; van den Heuvel, O. A.; Stein, D. J.; van Erp, T. G.; Ching, C.; Andreassen, O. A.; Hajek, T.; Opel, N.; Modinos, G.; Aleman, A.; van der Werf, Y.; Jahanshad, N.; Thomopoulos, S. I.; Thompson, P. M.; Carson, R. E.; Dagher, A.; Misic, B.

10.1101/2022.01.21.476409 — neuroscience — Posted on 2022-01-21

1389 Genomes of the extinct Sicilian wolf reveal a complex history of isolation and admixture with ancient dogs

Ciucani, M. M.; Ramos-Madrigal, J.; Hernandez-Alonso, G.; Alberto Carmagnini, A.; Aninta, S. G.; Scharff-Olsen, C. H.; Lanigan, L. T.; Fracasso, I.; Clausen, C. G.; Aspi, J.; Kojola, I.; Baltrunaite, L.; Balciauskas, L.; Moore, J.; Aakesson, M.; Saarma, U.; Hindrikson, M.; Hulva, P.; Bolfikova, B. C.; Nowak, C.; Godinho, R.; Smith, S.; Paule, L.; Nowak, S.; Myslajek, R. W.; Lo Brutto, S.; Ciucci, P.; Boitani, L.; Vernesi, C.; Stenoien, H. K.; Smith, O.; Frantz, L.; Rossi, L.; Angelici, F. M.; Cilli, E.; Sinding, M.-H. S.; Gilbert, M. T. P.; Gopalakrishnan, S.

10.1101/2022.01.21.477289 — genomics — Posted on 2022-01-21

1390 Multi-trait selection to build resilience in conifer forests: a case study on spruce-shoot weevil interactions

Klapste, J.; Jaquish, B.; Porth, I.

10.1101/2022.01.21.477209 — genetics — Posted on 2022-01-21

1391 Recruitment of Corticotropin-releasing Hormone CRH Neurons in response ton Categorically Distinct Stress Challenges in the Mouse Brain

Horvath, K.; Juhasz, B.; Kuti, D.; Torok, B.; Zelena, D.; Ferenczi, S.; Kovacs, K. J.

10.1101/2022.01.20.477065 — neuroscience — Posted on 2022-01-21

1392 Number neurons in the nidopallium of young domestic chicks

Kobylkov, D.; Mayer, U.; Zanon, M.; Vallortigara, G.

10.1101/2022.01.21.475044 — neuroscience — Posted on 2022-01-21

1393 RaMP-DB 2.0: a renovated knowledgebase for deriving biological and chemical insight from genes, proteins, and metabolites

Braisted, J.; Patt, A. C.; TIndall, C.; Eicher, T.; Sheils, T.; Neyra, J.; Spencer, K.; Mathe, E. A.

10.1101/2022.01.19.476987 — bioinformatics — Posted on 2022-01-21

1394 ATLIGATOR: Editing protein interactions with an atlas-based approach

Kynast, J. P.; Schwägerl, F.; Höcker, B.

10.1101/2022.01.19.476980 — bioinformatics — Posted on 2022-01-21

1395 Microenvironmental sensing by fibroblasts controls macrophage population size

Zhou, X.; Franklin, R. A.; Adler, M.; Carter, T. S.; Condiff, E.; Adams, T. S.; Pope, S. D.; Philip, N. H.; Meizlish, M. L.; Kaminski, N. S.; Medzhitov, R.

10.1101/2022.01.18.476683 — immunology — Posted on 2022-01-21

1396 Synaptic and intrinsic potentiation in O-LM interneurons is induced by theta patterns of stimulation

Sammari, M.; Inglebert, Y.; Ankri, N.; Russier, M.; Incontro, S.; Debanne, D.

10.1101/2022.01.19.476905 — neuroscience — Posted on 2022-01-21

1397 Environment constrains fitness advantages of division of labor in microbial consortia engineered for metabolite push or pull interactions

Carlson, R. P.; Beck, A. E.; Bleem, A.; Heys, J.; Gedeon, T.; Bernstein, H. C.; Schepens, D.; Harcombe, W. R.; Pintar, K.; Schrammeck, A.; Johnson, T.; Du, M.

10.1101/2022.01.19.477024 — synthetic biology — Posted on 2022-01-21

1398 Phenotypic dissection of epithelial lineages and therapeutic manipulation of differentiation programs in human Adenoid Cystic Carcinomas

Viragova, S.; Aparicio, L.; Zhao, J.; Valencia Salazar, L. E.; Schurer, A.; Dhuri, A.; Sahoo, D.; Moskaluk, C. A.; Rabadan, R.; Dalerba, P.

10.1101/2022.01.19.476843 — cancer biology — Posted on 2022-01-21

1399 Actin networks modulate heterogenous NF-κB dynamics in response to TNFα

Butera, F.; Sero, J. E.; Dent, L. G.; Bakal, C.

10.1101/2022.01.19.476961 — cancer biology — Posted on 2022-01-21

1400 Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer

Velenosi, T. J.; Krausz, K. W.; Hamada, K.; Dorsey, T.; Ambs, S.; Takahashi, S.; Gonzalez, F. J.

10.1101/2022.01.19.475906 — cancer biology — Posted on 2022-01-21

1401 MOJITOO: a fast and universal method for integration of multimodal single cell data

Cheng, M.; Li, Z.; Gesteira Costa Filho, I.

10.1101/2022.01.19.476907 — bioinformatics — Posted on 2022-01-21

1402 Pathogen Detection in RNA-Seq Data with Pathonoia

Liebhoff, A.-M.; Menden, K.; Laschtowitz, A.; Franke, A.; Schramm, C.; Bonn, S.

10.1101/2022.01.19.476681 — bioinformatics — Posted on 2022-01-21

1403 Is single-step genomic REML with the algorithm for proven and young more computationally efficient when less generations of data are present?

Junqueira, V. S.; Lourenco, D.; Masuda, Y.; Cardoso, F. F.; Lopes, P. S.; Silva, F. F.; Misztal, I.

10.1101/2022.01.19.476983 — genomics — Posted on 2022-01-21

1404 Bergmann's rule in Microlophus lizards: testing for latitudinal and climatic gradients of body size.

Toyama, K. S.; Boccia, C. K.

10.1101/2022.01.18.476846 — evolutionary biology — Posted on 2022-01-21

1405 Quantifying the effects of recent glacial history and future climate change on a unique population of mountain goats

Young, K. B.; Lewis, T. M.; White, K. S.; Shafer, A. B.

10.1101/2022.01.19.476931 — evolutionary biology — Posted on 2022-01-21

1406 Mapping cherry blossoms from geotagged street-level photos

Funada, S.; Tsutsumida, N.

10.1101/2022.01.18.476550 — ecology — Posted on 2022-01-21

1407 Tree size drives diversity and community structure of microbial communities on the bark of beech (Fagus sylvatica)

Dreyling, L.; Schmitt, I.; Dal Grande, F.

10.1101/2022.01.19.476951 — ecology — Posted on 2022-01-21

1408 Reduced feedback barely slows down proprioceptive recalibration

Ruttle, J. E.; 't Hart, B. M.; Henriques, D. Y. P.

10.1101/2022.01.19.476977 — neuroscience — Posted on 2022-01-21

1409 Behavioral and neurochemical effects of novel N-Benzyl-2-phenylethylamine derivatives in adult zebrafish

Demin, K. A.; Kupriyanova, O. V.; Shevyrin, V. A.; Derzhavina, K. A.; Krotova, N. A.; Ilyin, N. P.; Kolesnikova, T. O.; Galstyan, D. S.; Kositsyn, I. M.; Khaybaev, A.-A. S.; Seredinskaya, M. V.; Dubrovskii, Y.; Sadykova, R. G.; Nerush, M. O.; Mor, M. S.; Petersen, E. V.; Strekalova, T.; Efimova, E. V.; Bozhko, D. V.; Myrov, V. O.; Kolchanova, S. M.; Polovian, A. I.; Galumov, G. K.; Kalueff, A. V.

10.1101/2022.01.19.476767 — neuroscience — Posted on 2022-01-21

1410 Tracking the dynamics of perisaccadic visual signals with magnetoencephalography

Nasiotis, K.; Neupane, S.; Bakhtiari, S.; Baillet, S.; Pack, C. C.

10.1101/2022.01.19.476936 — neuroscience — Posted on 2022-01-21

1411 Implicit adaptation is modulated by the relevance of feedback

Parvin, D. E.; Dang, K. V.; Stover, A. R.; Ivry, R. B.; Morehead, R.

10.1101/2022.01.19.476924 — neuroscience — Posted on 2022-01-21

1412 Ultra-flexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon-dimension, Cuff-less Microneedle Electrode Array

Yan, D.; Jiman, A. A.; Bottorff, E. C.; Patel, P. R.; Meli, D.; Welle, E. J.; Ratze, D. C.; Havton, L. A.; Chestek, C. A.; Kemp, S. W. P.; Bruns, T. M.; Yoon, E.; Seymour, J. P.

10.1101/2022.01.19.476928 — neuroscience — Posted on 2022-01-21

1413 Adipose tissue dysfunction and visceral fat are associated to hepatic insulin resistance and severity of NASH even in lean individuals

Saponaro, C.; Sabatini, S.; Gaggini, M.; Carli, F.; Rosso, C.; Positano, V.; Armandi, A.; Caviglia, G. P.; Faletti, R.; Bugianesi, E.; Gastaldelli, A.

10.1101/2022.01.19.476711 — physiology — Posted on 2022-01-21

1414 mTOR is a Major Determinant of Chemosensitivity

Liu, Y.; Azizian, N. G.; Sullivan, D. K.; Li, Y.

10.1101/2022.01.19.476916 — cancer biology — Posted on 2022-01-21

1415 Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12

Wang, Z.; Wang, S.; Qin, J.; Zhang, X.; Lu, G.; Liu, H.; Guo, H.; Wu, L.; Shao, C.; Kong, B.; Liu, Z.

10.1101/2022.01.19.476862 — cancer biology — Posted on 2022-01-21

1416 Detecting Antibody Reactivities in Phage ImmunoPrecipitation Sequencing Data

Chen, A.; Kammers, K.; Larman, H. B.; Scharpf, R. B.; Ruczinski, I.

10.1101/2022.01.19.476926 — bioinformatics — Posted on 2022-01-21

1417 Predicting Mechanical Ventilation Effects on Six Human Tissue Transcriptomes

Somekh, J.; Lotan, N.; Yehuda, G. A.; Sussman, E.

10.1101/2022.01.19.476870 — bioinformatics — Posted on 2022-01-21

1418 Longitudinal Morphological and Functional Characterization of Human Heart Organoids Using Optical Coherence Tomography

Ming, Y.; Hao, S.; Xu, Z.; Goestenkors, A.; Lewis-Israeli, Y. R.; Volmert, B. D.; Aguirre, A.; Zhou, C.

10.1101/2022.01.19.476972 — bioengineering — Posted on 2022-01-21

1419 Improving the Identification Coverage of Protein Interactome by Enhancing the Click Chemistry-based Cross-linking Enrichment Efficiency

Zhao, L.; Zhao, Q.; An, Y.; Gao, H.; Zhang, X.; Liang, Z.; Zhang, L.; Zhang, Y.

10.1101/2022.01.21.475819 — biochemistry — Posted on 2022-01-21

1420 Rice Pan-genome Array (RPGA): an efficient genotyping solution for pan-genome-based accelerated crop improvement in rice

Daware, A.; Malik, A.; Srivastava, R.; Das, D.; Ellur, R. K.; Singh, A. K.; Tyagi, A. K.; Parida, S. K.

10.1101/2022.01.19.476884 — genomics — Posted on 2022-01-21

1421 Experimental Design and Power Calculation in Omics Circadian Rhythmicity Detection

Zong, W.; Seney, M. L.; Ketchesin, K. D.; Gorczyca, M. T.; Liu, A. C.; Esser, K. A.; Tseng, G.; McClung, C. A.; Huo, Z.

10.1101/2022.01.19.476930 — genomics — Posted on 2022-01-21

1422 A natural fungal gene drive enacts killing through targeting DNA

Urquhart, A. S.; Gardiner, D. M.

10.1101/2022.01.19.477016 — genetics — Posted on 2022-01-21

1423 Spatially Aware Dimension Reduction for Spatial Transcriptomics

Shang, L.; Zhou, X.

10.1101/2022.01.19.476966 — genetics — Posted on 2022-01-21

1424 Urban population structure and local movement ecology of a native Australian mosquito involved in disease transmission

Paris, V.; Rane, R.; Mee, P.; Lynch, S.; Hoffmann, A. A.; Schmidt, T. L.

10.1101/2022.01.18.476837 — ecology — Posted on 2022-01-21

1425 An early decline in ETPs reflects reduced pre-thymic progenitors and altered signals from the thymus microenvironment

Srinivasan, J.; Vasudev, A.; Selden, H. J.; Perez, E.; LaFleur, B. J.; Sinari, S. A.; Krueger, A.; Richie, E. R.; Ehrlich, L. I. R.

10.1101/2022.01.18.476832 — immunology — Posted on 2022-01-21

1426 A GSVA based gene set synergizing with CD4+T cell bearing harmful factors yield risk signals in HBV related diseases via amalgamation of artificial intelligence

Huang, J.; Zhao, C.; Zhang, X.; Zhao, Q.; Zhang, Y.; Chen, L.; Dai, G.

10.1101/2022.01.19.476726 — immunology — Posted on 2022-01-21

1427 Therapeutic Interruption of T Cell Development Generates High-Affinity T Cells That Escape Exhaustion and Improve Cancer Immunotherapy

Dhuey, E.; Oldridge, O.; Ravishankar, R.; Dada, H.; Yu, Y.; Anderson, M. S.; Minn, A. J.

10.1101/2022.01.19.476935 — immunology — Posted on 2022-01-21

1428 Inhibition of the IL-17A axis Protects against Immune-related Adverse Events while Supporting Checkpoint Inhibitor Anti-tumor Efficacy

Lechner, M. G.; Patel, A. Y.; Hugo, W.; Angell, T. E.; Cheng, M. I.; Pioso, M. S.; Hoang, A. T.; Yakobian, N.; McCarthy, E. C.; Chen, H.-C.; Rodriguez, E. D.; Guo, L.; Astourian, M.; Drakaki, A.; Famini, P.; Ribas, A.; Su, M. A.

10.1101/2022.01.19.476844 — immunology — Posted on 2022-01-21

Virtue-Griffiths, S. E.; Fornito, A.; Thompson, S.; Biabani, M.; Tiego, J.; Thapa, T.; Rogasch, N. C.

10.1101/2022.01.18.476852 — neuroscience — Posted on 2022-01-21

1430 Mosquito odorant receptor sensitive to natural spatial repellents and inhibitory compounds

Xu, P.; Choo, Y.-M.; An, S.; Leal, G. M.; Leal, W. S.

10.1101/2022.01.19.476929 — neuroscience — Posted on 2022-01-21

1431 Tissue volume estimation and age prediction using rapid structural brain scans

Hobday, H.; Cole, J. H.; Stanyard, R. A.; Daws, R. E.; Giampietro, V.; O'Daly, O.; Leech, R.; Vasa, F.

10.1101/2022.01.19.476615 — neuroscience — Posted on 2022-01-21

1432 Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke

Brunner, C.; Lagumersindez Denis, N.; Gertz, K.; Grillet, M.; Montaldo, G.; Endres, M.; Urban, A.

10.1101/2022.01.19.476904 — neuroscience — Posted on 2022-01-21

1433 A horizon for haptic perception

Miller, L. E.; Jarto, F.; Medendorp, W. P.

10.1101/2022.01.19.476921 — neuroscience — Posted on 2022-01-21

1434 Coupling a Live Cell Directed Evolution Assay with Coevolutionary Landscapes to Engineer an Improved Fluorescent Rhodopsin Chloride Sensor

Chi, H.; Zhou, Q.; Tutol, J. N.; Phelps, S. M.; Lee, J.; Kapadia, P.; Morcos, F.; Dodani, S. C.

10.1101/2022.01.20.474067 — synthetic biology — Posted on 2022-01-21

1435 BOS1 is a positive regulator of wounding induced cell death and plant susceptibility to Botrytis

Cui, F.; Li, X.; Wu, W.; Luo, W.; Wu, Y.; Brosche, M.; Overmyer, K.

10.1101/2022.01.18.476848 — plant biology — Posted on 2022-01-21

1436 Genome-wide analysis of small RNA biogenesis proteins refine the evolution of Dicer-like and Argonaute gene families in flowering plants

Belanger, S.; Zhan, J.; Meyers, B. C.

10.1101/2022.01.18.476847 — plant biology — Posted on 2022-01-21

1437 Heterosis and Combining Ability in Pumpkin Inbreds (Cucurbita moschata Duch. ex Poir.)

Shafin, M. S.; Haque, M. E.; Parvin, M. S.; Akhter, F.

10.1101/2022.01.16.476506 — plant biology — Posted on 2022-01-21

1438 Stabilization of E-cadherin adhesions by COX-2/GSK3β signaling is a targetable pathway in metastatic breast cancer

Balamurugan, K.; Sehareen, S.; Sharan, S.; Krishnamurthy, S.; Tang, W.; McKennett, L.; Padmanaba, V.; Czarra, K. T.; Ewald, A. J.; Ambs, S.; Ueno, N. T.; Poria, D. K.; Sterneck, E.

10.1101/2022.01.18.476813 — cancer biology — Posted on 2022-01-21

1439 Immunotherapy of glioblastoma explants induces interferon-γ responses and immune cell rearrangements in tumor center, but not periphery

Shekarian, T.; Zinner, C.; Bartoszek, E.; Duchemin, W.; Wachnowicz, A. T.; Hogan, S.; Etter, M. M.; Flammer, J.; Paganetti, C.; Martins, T.; Schmassmann, P.; Zanganeh, S.; LeGoff, F.; Muraro, M. G.; Ritz, M.-F.; Phillips, D.; Bhate, S.; Barlow, G. L.; Nolan, G.; Schuerch, C. M.; Hutter, G.

10.1101/2022.01.19.474897 — cancer biology — Posted on 2022-01-21

1440 Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung Cancers

Ouyang, H.; Chen, J.; Xu, C.; He, C.; Sheng, L.; Wang, J.; Pan, D.; Augert, A.; Lin, J.; Zhu, Y.; Jia, D.

10.1101/2022.01.19.475968 — cancer biology — Posted on 2022-01-21

1441 Lira: Rotational Invariant Shape and ElectrostaticDescriptors for Small Molecules and ProteinPockets based on Real Spherical Harmonics

Caires, F. R.; Silva, S. R.; Verissimo-Alves, M.; Pinheiro, V. B.; Montalvao, R. W.

10.1101/2022.01.19.476747 — bioinformatics — Posted on 2022-01-21

1442 Exploring genomic data coupled with 3D chromatin structures using the WashU Epigenome Browser

Li, D.; Purushotham, D.; Harrison, J. K.; Wang, T.

10.1101/2022.01.18.476849 — bioinformatics — Posted on 2022-01-21

1443 A novel, NADH-dependent acrylate reductase in Vibrio harveyi

Bertsova, Y. V.; Serebryakova, M.; Baykov, A. A.; Bogachev, A. V.

10.1101/2022.01.20.477176 — biochemistry — Posted on 2022-01-21

1444 Xeno-monitoring of molecular drivers of artemisinin and partner drug resistance in P. falciparum populations in malaria vectors across Cameroon

Nongley, N. F.; Mugenzi, L.; Tchouakui, M.; Nguiffo, D.; Wondji, M.; Mbakam, B.; Tchoupo, M.; Ndo, C.; Wanji, S.; Wondji, C. S.

10.1101/2022.01.19.476856 — genomics — Posted on 2022-01-21

1445 Oxygen availability drives blood traits and the cell number-size tradeoff across Andean hummingbirds

Williamson, J. L.; Linck, E. B.; Bautista, E.; Smiley, A.; McGuire, J. A.; Dudley, R.; Witt, C. C.

10.1101/2022.01.18.476833 — evolutionary biology — Posted on 2022-01-21

1446 Machine learning algorithms predict soil seed bank persistence from easily available traits

Rosbakh, S.; Pichler, M.; Poschlod, P.

10.1101/2022.01.19.476872 — ecology — Posted on 2022-01-21

1447 Quantitative proteomics of the CDK9 interactome reveals a novel function of the HSP90-CDC37-P-TEFb complex for BETi-induced HIV-1 latency reactivation

Wang, C.; Pan, Z.; He, Y.; Zhang, Z.; Liu, R.; Xue, Y.; Zhou, Q.; Gao, X.

10.1101/2022.01.20.477160 — molecular biology — Posted on 2022-01-21

1448 The influence of resource overlap on bacterial reproductive success in the phyllosphere

Schlechter, R. O.; Kear, E. J.; Bernach, M.; Remus, D. M.; Remus-Emsermann, M. N. P.

10.1101/2022.01.20.477054 — microbiology — Posted on 2022-01-21

1449 Insights into the Human Gut Virome by Sampling a Population from the Indian Subcontinent

Bhardwaj, K.; Garg, A.; Pandey, A. D.; Sharma, H.; kumar, M.; Vrati, S.

10.1101/2022.01.20.477175 — microbiology — Posted on 2022-01-21

1450 Tissue-intrinsic γδ T cells critically regulate Tissue-Resident Memory CD8 T cells

Munoz-Ruiz, M.; Llorian, M.; D'Antuono, R.; Pavlova, A.; Mavrigiannaki, A. M.; Mckenzie, D.; Garcia-Cassani, B.; Iannitto, M. L.; Jandke, A.; Ushakov, D.; Adrian C. Hayday, A.

10.1101/2022.01.19.476598 — immunology — Posted on 2022-01-21

1451 The effects of electroencephalogram feature-based transcranial alternating current stimulation on working memory and electrophysiology

Zeng, L.; Guo, M.; Wu, R.; Luo, Y.; Wei, P.

10.1101/2022.01.19.476885 — neuroscience — Posted on 2022-01-21

1452 Engineered bacterial swarm patterns as spatial records of environmental inputs

Doshi, A.; Shaw, M.; Tonea, R.; Moon, S.; Doshi, A.; Laine, A.; Guo, J.; Danino, T.

10.1101/2022.01.20.477106 — synthetic biology — Posted on 2022-01-21

1453 Regulation of balanced root fungal community of Vanda falcata (Orchidaceae) by partitioning its mycorrhizal fungi and ascomycetous fungi across growth and development

Pujasatria, G. C.; Nishiguchi, I.; Miura, C.; Yamato, M.; Kaminaka, H.

10.1101/2022.01.18.476577 — plant biology — Posted on 2022-01-21

1454 ReadItAndKeep: rapid decontamination of SARS-CoV-2 sequencing reads

Hunt, M.; Swann, J.; Constantinides, B.; Fowler, P. W.; Iqbal, Z.

10.1101/2022.01.21.477194 — bioinformatics — Posted on 2022-01-21

1455 Deep learning based on multi-omics integration identifies potential therapeutic targets in breast cancer

Pan, X.; Burgman, B.; Sahni, N.; Yi, S. S.

10.1101/2022.01.18.476842 — bioinformatics — Posted on 2022-01-21

1456 Nanoformulated Remdesivir with Extremely Low Content of Poly(2-oxazoline) - Based Stabilizer for Aerosol Treatment of COVID-19

Ramsey, J. D.; Stewart, I. E.; Madden, E. A.; Lim, C.; Hwang, D.; Heise, M. T.; Hickey, A. J.; Kabanov, A. V.

10.1101/2022.01.21.477258 — bioengineering — Posted on 2022-01-21

1457 Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria

Shi, Y.-M.; Hirschmann, M.; Shi, Y.-N.; Ahmed, S.; Abebew, D.; Tobias, N. J.; Gruen, P.; Crames, J. J.; Poeschel, L.; Kuttenlochner, W.; Richter, C.; Herrmann, J.; Mueller, R.; Thanwisai, A.; Pidot, S. J.; Stinear, T. P.; Groll, M.; Kim, Y.; Bode, H. B.

10.1101/2022.01.21.477171 — biochemistry — Posted on 2022-01-21

1458 PROTAC-mediated selective degradation of cytosolic soluble epoxide hydrolase enhances ER-stress reduction

Wang, Y.; Morisseau, C.; Takamura, A.; Wan, D.; Li, D.; Wolan, D. W.; Hammock, B. D.; Kitamura, S.

10.1101/2022.01.20.477134 — biochemistry — Posted on 2022-01-21

1459 Reconstitution of an active human CENP-E motor

Craske, B.; Legal, T.; Welburn, J.

10.1101/2022.01.21.477187 — biochemistry — Posted on 2022-01-21

1460 Developing all-in-one virus-like particles for Cas9 mRNA/single guide RNA co-delivery and aptamer-containing lentiviral vectors for improved gene expression

Yadav, M. K.; Atala, A.; Lu, B.

10.1101/2022.01.19.476334 — genomics — Posted on 2022-01-21

1461 Knockout of Bbs10 results in lack of cone electrical function and progressive retinal degeneration of rods and cones

Mayer, S. K.; Thomas, J.; Helms, M.; Kothapalli, A. K.; Cherascu, I.; Stalter, E.; Wang, K.; Datta, P.; Searby, C.; Seo, S.; Hsu, Y.; Bhattarai, S.; Sheffield, V. C.; Drack, A. V.

10.1101/2022.01.19.476952 — genetics — Posted on 2022-01-21

1462 Claspin is required for growth recovery from serum starvation through regulating the PI3K-PDK1-mTOR pathway

Yang, C.-C.; Masai, H.

10.1101/2022.01.21.475743 — molecular biology — Posted on 2022-01-21

1463 Promoting Fc-Fc interactions between anti-capsular antibodies provides strong complement-dependent immune protection against Streptococcus pneumoniae

Aguinagalde, L.; den Boer, M. A.; Castenmiller, S.; Zwarthoff, S.; de Haas, C. J. C.; Aerts, P.; Beurskens, F. J.; Schuurman, J.; Heck, A. J. R.; Kessel, K. V.; Rooijakkers, S.

10.1101/2022.01.21.477211 — microbiology — Posted on 2022-01-21

1464 Outbreak.info: A standardized, searchable platform to discover and explore COVID-19 resources and data

Tsueng, G.; Mullen, J.; Alkuzweny, M.; Cano, M. A.; Rush, B.; Haag, E.; Outbreak Curators, ; Latif, A. A.; Zhou, X.; Qian, Z.; Andersen, K. G.; Wu, C.; Su, A. I.; Gangavarapu, K.; Hughes, L. D.

10.1101/2022.01.20.477133 — bioinformatics — Posted on 2022-01-21

1465 Cold Tolerance is Governed by Diverse Genetic Mechanisms Including Those Regulated by NB-LRR-type Receptor Proteins in Arabidopsis.

Sahoo, D. K.; Hegde, C.; Bhattacharyya, M. K.

10.1101/2022.01.18.476799 — plant biology — Posted on 2022-01-21

1466 High-resolution map of plastid encoded polymerase binding patterns demonstrates a major role of transcription in chloroplast gene expression

Palomar, M.; Jaksich, S.; Fujii, S.; Kucinski, J.; Wierzbicki, A.

10.1101/2022.01.18.476797 — plant biology — Posted on 2022-01-21

1467 Pareto-optimal trade-off for phenotypic switching of populations in a stochastic environment

Lacoste, D.; Unterberger, J.; Dinis, L.

10.1101/2022.01.18.476793 — biophysics — Posted on 2022-01-21

1468 Optimus: a general purpose adaptive optimisation engine in R

Johnson, N. A. G.; Tamon, L.; Liu, X.; Sahakyan, A. B.

10.1101/2022.01.18.476810 — bioinformatics — Posted on 2022-01-21

1469 Ancient herpes simplex 1 genomes reveal recent viral structure in Eurasia

Guellil, M.; van Dorp, L.; Inksip, S. A.; Dittmar, J. M.; Saag, L.; Tambets, K.; Hui, R.; Rose, A.; D'Atanasio, E.; Kriiska, A.; Varul, L.; Koekkelkoren, A. M. H. C.; Goldina, R. D.; Cessford, C.; Solnik, A.; Metspalu, M.; Krause, J.; Herbig, A.; Robb, J. E.; Houldcroft, C.; Scheib, C. L.

10.1101/2022.01.19.476912 — genomics — Posted on 2022-01-21

1470 Complex genetic architecture underlying the plasticity of maize agronomic traits

Jin, M.; Liu, H.; Liu, X.; Guo, T.; Guo, J.; Yin, Y.; Ji, Y.; Li, Z.; Zhang, J.; Wang, X.; Qiao, F.; Xiao, Y.; Zan, Y.; Yan, J.

10.1101/2022.01.18.476828 — genetics — Posted on 2022-01-21

1471 Warming decreases host survival with multiple parasitoids, but parasitoid performance also decreases

Thierry, M.; Pardikes, N.; Rosenbaum, B.; Ximenez-Embun, M. G.; Hrcek, J.

10.1101/2021.08.24.457463 — ecology — Posted on 2022-01-21

1472 Use of object detection in camera trap image identification: assessing a method to rapidly and accurately classify human and animal detections for research and application in recreation ecology

Fennell, M. J. E.; Beirne, C. W.; Burton, C.

10.1101/2022.01.14.476404 — ecology — Posted on 2022-01-21

1473 Alternative splicing changes are associated with pre-birth adaptation during lung development

Fidalgo, M. F.; Fonseca, C. G.; Caldas, P.; Raposo, A. A.; Balboni, T.; Rita Grosso, A.; Vasconcelos, F. F.; Franco, C. A.

10.1101/2022.01.19.476886 — developmental biology — Posted on 2022-01-21

1474 JWA deficiency accelerates aging through disrupting intestinal epithelial homeostasis via Notch1/PPARγ/Stat5 axis

Zhou, J.; Li, X.; Liu, J.; Wang, L.; Zhou, Y.; Wen, Y.; ding, k.; Zou, L.; Liu, X.; Li, A.; Wang, Y.; Fu, H.; Huang, M.; Ding, G.

10.1101/2022.01.17.476552 — developmental biology — Posted on 2022-01-21

1475 CD155 and EndoA1 mediate growth and tissue invasion downstream of MAP4K4 in medulloblastoma cells

Capdeville, C.; Russo, L.; Penton, D.; Migliavacca, J.; Zecevic, M.; Gries, A.; Neuhauss, S. C. F.; Grotzer, M. A.; Baumgartner, M.

10.1101/2021.08.10.455785 — cell biology — Posted on 2022-01-21

1476 Sialic acid and fucose residues on the SARS-CoV-2 receptor binding domain modulate IgG reactivity

Samuelsson, E.; Mirgorodskaya, E.; Nyström, K.; Bäckström, M.; Liljeqvist, J.-A.; Norden, R.

10.1101/2022.01.20.477056 — molecular biology — Posted on 2022-01-21

1477 Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 Spike protein

Caohuy, H.; Eidelman, O.; Chen, T.; Yang, Q.; Walton, N. I.; Pollard, H. B.

10.1101/2022.01.18.476803 — microbiology — Posted on 2022-01-21

1478 A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection

Zhou, P.; Yuan, M.; Song, G.; Beutler, N.; Shaabani, N.; Huang, D.; He, W.-t.; Zhu, X.; Callaghan, S.; Yong, P.; Anzanello, F.; Peng, L.; Ricketts, J.; Parren, M.; Garcia, E.; Rawlings, S. A.; Smith, D. M.; Nemazee, D.; Teijaro, J. R.; Rogers, T.; Wilson, I. A.; Burton, D. R.; Andrabi, R.

10.1101/2021.03.30.437769 — immunology — Posted on 2022-01-21

1479 Effects of transcranial magnetic stimulation on the human brain recorded with intracranial electrocorticography: First-in-human study

Wang, J. B.; Bruss, J.; Oya, H.; Uitermarkt, B. D.; Trapp, N. T.; Gander, P. E.; Howard, M. A.; Keller, C. J.; Boes, A.

10.1101/2022.01.18.476811 — neuroscience — Posted on 2022-01-21

1480 Non-zero Mean Alpha Oscillations are Evident in Computational Model and Empirical Data

Studenova, A. A.; Villringer, A.; Nikulin, V. V.

10.1101/2021.12.01.470793 — neuroscience — Posted on 2022-01-21

1481 The synaptic vesicle protein Mover/TPRG1L is associated with lipid droplets in astrocytes

Krohn, J.; Domart, F.; Dresbach, T.

10.1101/2022.01.18.476809 — neuroscience — Posted on 2022-01-21

1482 Probabilistic representations as building blocks for higher-level vision

Chetverikov, A.; Kristjansson, A.

10.1101/2021.11.18.469104 — neuroscience — Posted on 2022-01-21

1483 Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

Gueguinou, M.; Ibrahim, S.; Bourgeais, J.; Robert, A.; Pathak, T.; Zhang, X.; Crottes, D.; Dupuy, J.; Ternant, D.; Monbet, V.; Guibon, R.; Flores-Romero, H.; Lefevre, A.; Lerondel, S.; Le Pape, A.; Dumas, J.-F.; Frank, P. G.; Girault, A.; Chautard, R.; Gueraud, F.; Garcia-Saez, A. J.; Ouaissi, M.; Emond, P.; Sire, O.; Herault, O.; Fromont-Hankard, G.; Vandier, C.; Tougeron, D.; Trebak, M.; Raoul, W.; Lecomte, T.

10.1101/2022.01.18.476775 — cancer biology — Posted on 2022-01-21

1484 Septin-Mediated Mechanobiological Reprogramming of T Cell Transmigration and 3D Motility

Zhovmer, A. S.; Manning, A.; Smith, C.; Vishweshwaraiah, Y. L.; Wang, J.; Saez, P. J.; Ma, X.; Cartagena-Rivera, A. X.; Singh, R. K.; Dokholyan, N. V.; Tabdanov, E. D.

10.1101/2022.01.18.476840 — biophysics — Posted on 2022-01-21

1485 Relationship between monomer packing, receptor binding domain pocket status, and pH, in the spike trimer of SARS-CoV-2 variants

Warwicker, J.

10.1101/2021.12.14.472554 — bioinformatics — Posted on 2022-01-21

1486 A comparison of high resolution image reconstruction methods from confocal array detector with a new deconvolution algorithm

Prigent, S.; Dutertre, S.; Bidaud-Meynard, A.; Bertolin, G.; Michaux, G.; Kervrann, C.

10.1101/2021.08.02.454749 — bioinformatics — Posted on 2022-01-21

1487 Deep learning tools and modeling to estimate the temporal expression of cell cycle proteins from 2D still images

Pecot, T.; Cuitino, M. C.; Johnson, R. H.; Timmers, C.; Leone, G.

10.1101/2021.03.01.433386 — bioinformatics — Posted on 2022-01-21

1488 Contribution of arm movements to balance recovery after tripping in older adults.

Bruijn, S. M.; Sloot, L.; Kingma, I.; Pijnappels, M.

10.1101/2021.08.03.454896 — animal behavior and cognition — Posted on 2022-01-21

1489 Genome-wide association and prediction study in grapevine deciphers the genetic architecture of multiple traits and identifies genes under many new QTLs

Flutre, T.; Le Cunff, L.; Fodor, A.; Launay, A.; Romieu, C.; Berger, G.; Bertrand, Y.; Terrier, N.; Beccavin, I.; Bouckenooghe, V.; Roques, M.; Pinasseau, L.; Verbaere, A.; Sommerer, N.; Cheynier, V.; Bacilieri, R.; Boursiquot, J.-M.; Lacombe, T.; Laucou, V.; This, P.; Peros, J.-P.; Doligez, A.

10.1101/2020.09.10.290890 — genetics — Posted on 2022-01-21

1490 The Intrinsically Disordered Region of Coronins Fine-tunes Oligomerization and Actin Polymerization

Han, X.; Hu, Z.; Surya, W.; Ma, Q.; Zhou, F.; Nordenskiöld, L.; Torres, J.; Lu, L.; Miao, Y.

10.1101/2022.01.19.477021 — cell biology — Posted on 2022-01-21

1491 Bone marrow age dictates clonality of smooth muscle-derived cells in the atherosclerotic plaque

Kabir, I.; Zhang, X.; Dave, J.; Chakraborty, R.; Qu, R.; Chandran, R. R.; Ntokou, A.; Aryal, B.; Rotllan, N.; Garcia-Milian, R.; Hwa, J.; Klugar, Y.; Martin, K. A.; Fernandez-Hernando, C.; Greif, D. M.

10.1101/2022.01.18.476756 — cell biology — Posted on 2022-01-21

1492 An extended reservoir of class-D beta-lactamases in non-clinical bacterial strains

Lupo, V.; Mercuri, P. S.; Frere, J.-M.; Joris, B.; Galleni, M.; Baurain, D.; Kerff, F.

10.1101/2022.01.19.477027 — microbiology — Posted on 2022-01-21

1493 Fever temperatures impair hemolysis caused by strains of Escherichia coli and Staphylococcus aureus

Palela, M.; Giol, E. D.; Amzuta, A.; Ologu, O.; Stan, R.

10.1101/2020.11.23.393553 — microbiology — Posted on 2022-01-21

1494 Reduced metabolic activity in established Gardnerella spp. biofilms contributes to protection from the bactericidal effects of metronidazole

Khan, S.; Hill, J. E.

10.1101/2021.09.06.459156 — microbiology — Posted on 2022-01-21

1495 Macrophage network dynamics depend on haptokinesis for optimal local surveillance

Paterson, N.; Lämmermann, T.

10.1101/2021.11.21.469249 — immunology — Posted on 2022-01-21

1496 Excessive self-grooming of Shank3 mutant mice is associated with gene dysregulation and imbalance between the striosome and matrix compartments in the striatum

Ferhat, A.-T.; Biton, A.; Verpy, E.; Forget, B.; de Chaumont, F.; Mueller, F.; Le Sourd, A.-M.; Coqueran, S.; Schmitt, J.; Rochefort, C.; Rondi-Reig, L.; Leboucher, A.; Boland, A.; Fin, B.; Deleuze, J.-F.; Boeckers, T.; Ey, E.; Bourgeron, T.

10.1101/2022.01.19.476922 — neuroscience — Posted on 2022-01-21

1497 BrainStat: A toolbox for brain-wide statistics and neuroscientific contextualization

Vos de Wael, R.; Bayrak, S.; Benkarim, O.; Herholz, P.; Lariviere, S.; Rodriguez-Cruces, R.; Paquola, C.; Hong, S.-J.; Misic, B.; Evans, A.; Valk, S.; Bernhardt, B.

10.1101/2022.01.18.476795 — neuroscience — Posted on 2022-01-21

1498 Bursting emerges from the complementary roles of neurons in a four-cell network

Sakurai, A.; Katz, P. S.

10.1101/2021.08.05.455351 — neuroscience — Posted on 2022-01-21

1499 An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Seuma, M.; Lehner, B.; Bolognesi, B.

10.1101/2022.01.18.476804 — genomics — Posted on 2022-01-21

1500 Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels

Barro Soria, R.; Edmond, M. A.; Hinojo-Perez, A.; Wu, X.; Perez, M. E.

10.1101/2022.01.19.476944 — biophysics — Posted on 2022-01-21

1501 GM1a functions as a coreceptor/ attachment factor for Dengue virus during infection in mammalian systems

Tantirimudalige, S. N.; Raghuvamsi, P. V.; Wei Bao, J. C.; Anand, G. S.; Wohland, T.

10.1101/2022.01.20.477180 — biophysics — Posted on 2022-01-21

1502 Basal amygdala inputs to the medial prefrontal cortex mediate fear memory strengthening

Einarsson, E.; Flores, A.; Jercog, D.; Herry, C.

10.1101/2022.01.20.477064 — neuroscience — Posted on 2022-01-21

1503 Astrocyte glutamate transport is modulated by motor learning and regulates neuronal correlations and movement encoding by motor cortex neurons

Delepine, C.; Li, K.; Shih, J.; Gaudeaux, P.; Sur, M.

10.1101/2022.01.20.477039 — neuroscience — Posted on 2022-01-21

1504 Active Predictive Coding Networks: A Neural Solution to the Problem of Learning Reference Frames and Part-Whole Hierarchies

Gklezakos, D. C.; Rao, R. P. N.

10.1101/2022.01.20.477125 — neuroscience — Posted on 2022-01-21

1505 Depletion of Scleraxis-lineage cells accelerates tendon ECM aging and promotes retention of a specialized remodeling tenocyte population that drives enhanced tendon healing

Korcari, A.; Nichols, A. E.; Loiselle, A. E.

10.1101/2022.01.20.477119 — cell biology — Posted on 2022-01-21

1506 Heterogeneity in Neuronal Dynamics is Learned by Gradient Descent for Temporal Processing Tasks

Winston, C.; Mastrovito, D.; Shea-Brown, E.; Mihalas, S.

10.1101/2022.01.19.476851 — neuroscience — Posted on 2022-01-21

1507 A genetically-defined population in the lateral and ventrolateral periaqueductal gray selectively promotes flight to safety

La-Vu, M.; Sethi, E.; Maesta-Pereira, S.; Schuette, P. J.; Tobias, B. C.; Reis, F. M.; Wang, W.; Leonard, S. J.; Lin, L.; Adhikari, A.

10.1101/2022.01.19.476981 — neuroscience — Posted on 2022-01-21

1508 Neurodevelopmental oscillatory basis of speech processing in noise

Bertels, J.; Niesen, M.; Destoky, F.; Coolen, T.; Vander Ghinst, M.; Wens, V.; Rovai, A.; Trotta, N.; Baart, M.; Molinaro, N.; De Tiege, X.; Bourguignon, M.

10.1101/2022.01.20.476739 — neuroscience — Posted on 2022-01-21

1509 A mixed generative model of auditory word repetition

Sajid, N.; Holmes, E.; Da Costa, L.; Price, C.; Friston, K.

10.1101/2022.01.20.477138 — neuroscience — Posted on 2022-01-21

1510 Caulobacter requires anionic sphingolipids and deactivation of fur to lose lipid A

Zik, J. J.; Yoon, S. H.; Guan, Z.; Skidmore, G. S.; Gudoor, R. R.; Davies, K. M.; Deutschbauer, A. M.; Goodlett, D. R.; Klein, E. A.; Ryan, K. R.

10.1101/2022.01.20.477143 — microbiology — Posted on 2022-01-21

1511 Spatially coherent diffusion of human RNA Pol II depends on transcriptional state rather than chromatin motion

Barth, R.; Shaban, H. A.

10.1101/2022.01.19.476954 — biophysics — Posted on 2022-01-21

1512 gmxapi: a Gromacs-native Python interface for molecular dynamics with ensemble and plugin support

Irrgang, M. E.; Davis, C.; Kasson, P.

10.1101/2021.07.18.452496 — bioinformatics — Posted on 2022-01-21

1513 Benchmarking Computational Integration Methods for Spatial Transcriptomics Data

Li, Y.; Stanojevic, S.; He, B.; Jing, Z.; Huang, Q.; Kang, J.; Garmire, L.

10.1101/2021.08.27.457741 — bioinformatics — Posted on 2022-01-21

1514 m6A reader Pho92 is recruited co-transcriptionally and couples translation efficacy to mRNA decay to promote meiotic fitness in yeast

Varier, R. A.; Sideri, T.; Capitanchik, C.; Manova, Z.; Calvani, E.; Rossi, A.; Edupuganti, R.; Ensinck, I.; Chan, V. W. C.; Patel, H.; Kirkpatrick, J.; Faull, P.; Snijders, A. P.; Vermeulen, M.; Ralser, M.; Ule, J.; Luscombe, N. M.; van Werven, F.

10.1101/2022.01.20.477035 — biochemistry — Posted on 2022-01-21

1515 Nulliparity affects the expression of a limited number of genes and pathways in Day 8 equine embryos

Derisoud, E.; Jouneau, L.; Archilla, C.; Jaszczyszyn, Y.; Legendre, R.; Daniel, N.; Peynot, N.; Dahirel, M.; Auclair-Ronzaud, J.; Duranthon, V.; Chavatte-Palmer, P.

10.1101/2022.01.19.476782 — developmental biology — Posted on 2022-01-21

1516 Mutation of Vsx genes in zebrafish highlights the robustness of the retinal specification network.

Letelier, J.; Buono, L.; Almuedo-Castillo, M.; Zang, J.; Gonzalez-Diaz, S.; Polvillo, R.; Sanabria-Reinoso, E.; Diez del Corral, R.; Neuhauss, S. C. F.; Martinez-Morales, J. R.

10.1101/2022.01.20.477122 — developmental biology — Posted on 2022-01-21

1517 Myogenic regulatory factors MyoD and Myf5 are required for dorsal aorta formation and angiogenic sprouting

Paulissen, E.; Martin, B. L.

10.1101/2022.01.20.477095 — developmental biology — Posted on 2022-01-21

1518 Identification of a Golgi-localized altORF peptide reveals a minimal Golgi targeting motif

Navarro, A. P.; Cheeseman, I. M.

10.1101/2020.12.13.422530 — cell biology — Posted on 2022-01-21

1519 A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

Jenks, J. A.; Amin, S.; Kumar, A.; Sponholtz, M. R.; Wrapp, D.; Venkatayogi, S.; Tu, J.; McLellan, J. S.; Wiehe, K.; Permar, S. R.

10.1101/2022.01.19.476974 — microbiology — Posted on 2022-01-21

1520 ORIGIN OF THREE RELATED MOVEMENT GENE MODULES IN PLANT VIRUSES: EVOLUTIONARY RADIATIONS OF BENYVIRUS-LIKE RNA REPLICONS

Morozov, S.; Solovyev, A. G.

10.1101/2022.01.19.477018 — microbiology — Posted on 2022-01-21

1521 Trophic transfer of microplastics enhances tissue accumulation of chemical additives in fish

Hasegawa, T.; Mizukawa, K.; Geok Yeo, B.; Sekioka, T.; Takada, H.; Nakaoka, M.

10.1101/2021.03.09.434685 — pharmacology and toxicology — Posted on 2022-01-21

1522 Membrane-mediated interactions between hinge-like particles

Li, B.; Abel, S. M.

10.1101/2022.01.19.476938 — biophysics — Posted on 2022-01-21

1523 A molecular dynamics study of antimicrobial peptide translocation across the outer membrane of Gram-negative bacteria

Sharma, P.; Ayappa, K. G.

10.1101/2022.01.20.477041 — biophysics — Posted on 2022-01-21

1524 Dynamics and structural changes of calmodulin upon interaction with its potent antagonist calmidazolium

Leger, C.; Pitard, I.; Sadi, M.; Carvalho, N.; Brier, S.; Mechaly, A.; Raoux Barbot, D.; Davi, M.; Hoos, S.; Weber, P.; Vachette, P.; Durand, D.; Haouz, A.; Guijarro, J. I.; Ladant, D.; CHENAL, A.

10.1101/2022.01.19.474921 — biophysics — Posted on 2022-01-21

1525 Improving Small Molecule pKa Prediction Using Transfer Learning with Graph Neural Networks

Mayr, F.; Wieder, M.; Wieder, O.; Langer, T.

10.1101/2022.01.20.476787 — biophysics — Posted on 2022-01-21

1526 Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs

Chiu, S.-H.; Ho, W.-L.; Sun, Y.-C.; Kuo, J.-C.; Huang, J.-r.

10.1101/2022.01.19.476903 — biophysics — Posted on 2022-01-21

1527 Enhancing Sampling of Water Rehydration on Ligand Binding: A Comparison of Techniques

Ge, Y.; Wych, D. C.; Samways, M. L.; Wall, M. E.; Essex, J. W.; Mobley, D. L.

10.1101/2021.06.14.448350 — biophysics — Posted on 2022-01-21

1528 Tethering designer short double-stranded RNA to mRNA for co-delivery of molecularly-targeted adjuvants and antigens towards cancer vaccination

Tockary, T. A.; Abbasi, S.; Masai, M.; Yoshinaga, N.; Fukushima, S.; Kataoka, K.; Uchida, S.

10.1101/2022.01.18.476829 — bioengineering — Posted on 2022-01-21

1529 Nucleosome topology and DNA sequence modulate the engagement of pioneer factors SOX2 and OCT4

Malaga Gadea, F. C.; Nikolova, E. N.

10.1101/2022.01.18.476780 — biochemistry — Posted on 2022-01-21

1530 Genomic databanks and targeted assays help characterise mosquito incursions within Australia

Schmidt, T. L.; Endersby-Harshman, N.; Kurucz, N.; Pettit, W.; Krause, V.; Ehlers, G.; Muzari, O.; Currie, B. J.; Hoffmann, A. A.

10.1101/2022.01.19.477022 — genomics — Posted on 2022-01-21

1531 Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes

Monti, R.; Rautenstrauch, P.; Ghanbari, M. L.; James, A. R.; Ohler, U.; Konigorski, S.; Lippert, C.

10.1101/2021.05.27.444972 — genetics — Posted on 2022-01-20

1532 Evolution of class-structured populations in fluctuating environments

Lion, S.; Gandon, S.

10.1101/2021.03.12.435065 — evolutionary biology — Posted on 2022-01-20

1533 Research on the temporal evolution track and influence of green development in the last decade

Chen, Y.; Lai, Q.; Ji, X.

10.1101/2022.01.20.477152 — ecology — Posted on 2022-01-21

1534 Lysosomes are Required for Early Dorsal Signaling in the Xenopus Embryo

Tejeda Munoz, N.; De Robertis, E. M.

10.1101/2022.01.19.476939 — developmental biology — Posted on 2022-01-20

1535 Cell cycle dynamics controls fluidity of the developing mouse neuroepithelium

Bocanegra-Moreno, L.; Singh, A.; Hannezo, E.; Zagorski, M.; Kicheva, A.

10.1101/2022.01.20.477048 — developmental biology — Posted on 2022-01-20

1536 A key role for p60-Katanin in axon navigation is conditioned by the tubulin polyglutamylase TTLL6

Ten Martin, D.; Jardin, N.; Giudicelli, F.; Gasmi, L.; Vougny, J.; Haumaitre, C.; Nicol, X.; Janke, C.; Fassier, C.; Hazan, J.

10.1101/2022.01.20.477127 — developmental biology — Posted on 2022-01-20

1537 An ancient role for the Hippo pathway in axis formation and morphogenesis

Brooun, M.; Salvenmoser, W.; Dana, C.; Sudol, M.; Steele, R.; Hobmayer, B.; McNeill, H.

10.1101/2022.01.19.476962 — developmental biology — Posted on 2022-01-20

1538 High Hedgehog signaling is transduced by a multikinase-dependent switch controling the apico-basal distribution of the GPCR Smoothened.

Goncalves-Antunes, M.; Sanial, M.; Contremoulins, V.; Carvalho, S.; Plessis, A.; Becam, I.

10.1101/2022.01.19.476759 — developmental biology — Posted on 2022-01-20

1539 Identification and characterization of a dlx2b cis-regulatory element both sufficient and necessary for correct transcription during zebrafish tooth development

Jackman, W. R.; Moon, Y.; Anderson, D. R.; DeFusco, A. A.; Nguyen, V. M.; Liu, S. Y.; Carter, E. H.; Littleford, H. E.; Richards, E. K.; Jowdry, A. L.

10.1101/2022.01.20.477116 — developmental biology — Posted on 2022-01-21

1540 Understanding the development of oral epithelial organs through single cell transcriptomic analysis

Ye, Q.; Bhojwani, A.; Hu, J. K.

10.1101/2022.01.18.476858 — developmental biology — Posted on 2022-01-21

1541 CONTEXT-DEPENDENT ENHANCER FUNCTION REVEALED BYTARGETED INTER-TAD RELOCATION

Bolt, C. C.; Lopez-Delisle, L.; Hintermann, A.; Mascrez, B.; Rauseo, A.; Andrey, G.; Duboule, D.

10.1101/2022.01.19.476888 — developmental biology — Posted on 2022-01-21

1542 NGF-p75 signaling coordinates skeletal cell migration during bone repair

Xu, J.; Li, Z.; Tower, R. J.; Negri, S.; Wang, Y.; Meyers, C. A.; Sono, T.; Qin, Q.; Lu, A.; Xing, X.; McCarthy, E. F.; Clemens, T. L.; James, A. W.

10.1101/2021.07.07.451468 — cell biology — Posted on 2022-01-20

1543 Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

Chondronasiou, D.; Gill, D.; Mosteiro, L.; Urdinguio, R. G.; Berenguer, A.; Aguilera, M.; Durand, S.; Aprahamian, F.; Nirmalathasan, N.; Abad, M.; Martin-Herranz, D. E.; Stephan-Otto Attolini, C.; Prats, N.; Kroemer, G.; Fraga, M. F.; Reik, W.; Serrano, M.

10.1101/2022.01.20.477063 — cell biology — Posted on 2022-01-21

1544 Pore-C Simultaneously Captures Genome-wide Multi-way Chromatin Interaction and Associated DNA Methylation Status in Arabidopsis

Li, Z.; Long, Y.; Yu, Y.; Zhang, F.; Zhang, H.; Liu, Z.; Jia, J.; Mo, W.; Tian, S. Z.; Zheng, M.; Zhai, J.

10.1101/2022.01.20.477161 — molecular biology — Posted on 2022-01-21

1545 SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

Choi, J.-H.; Zhang, X.; Zhang, C.; Dai, D. L.; Luo, J.; Ladak, R.; Li, Q.; Wiebe, S.; Liu, A. C. H.; Ran, X.; Yang, J.; Naeli, P.; Garzia, A.; Zhou, L.; Mahmood, N.; Deng, Q.; Elaish, M.; Lin, R.; Hobman, T.; Pelletier, J.; Alain, T.; Vidal, S.; Duchaine, T.; Mazhab-Jafari, M.; Mao, X.; Jafarnejad, S. M.; Sonenberg, N.

10.1101/2022.01.19.476693 — microbiology — Posted on 2022-01-20

1546 Environmental and taxonomic drivers of bacterial extracellular vesicle production in marine ecosystems

Biller, S.; Coe, A.; Arellano, A. A.; Dooley, K.; Gong, J. S.; Yeager, E. A.; Becker, J. W.; Chisholm, S. W.

10.1101/2022.01.18.476865 — microbiology — Posted on 2022-01-20

1547 Profiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling device

Shalon, D.; Culver, R. N.; Grembi, J. A.; Folz, J.; Treit, P.; Dethlefsen, L.; Meng, X.; Yaffe, E.; Spencer, S.; Shi, H.; Aranda-Diaz, A.; Patterson, A. D.; Triadafilopoulos, G.; Holmes, S. P.; Mann, M.; Fiehn, O.; Relman, D.; Huang, K.

10.1101/2022.01.19.476920 — microbiology — Posted on 2022-01-20

1548 Intra-granuloma accumulation and inflammatory differentiation of neutrophils underlie mycobacterial ESX-1-mediated immunopathology

Lienard, J.; Munke, K.; Wulff, L.; Da Silva, C.; Vandamme, J.; Laschanzky, K.; Joeris, T.; Agace, W.; Carlsson, F.

10.1101/2022.01.19.477031 — microbiology — Posted on 2022-01-20

1549 Metabolic phenotyping of marine heterotrophs on refactored media reveals diverse metabolic adaptations and lifestyle strategies

Forchielli, E. J.; Sher, D. J.; Segre, D.

10.1101/2022.01.07.475430 — microbiology — Posted on 2022-01-20

1550 Pathogenicity of SARS-CoV-2 Omicron in Syrian hamsters and its neutralization with different Variants of Concern

Mohandas, S.; Yadav, P. D.; Sapkal, G.; Shete, A. M.; Deshpande, G.; Nyayanit, D. A.; Patil, D. Y.; Kadam, M.; Kumar, A.; Mote, C.; Jain, R.

10.1101/2022.01.19.477013 — microbiology — Posted on 2022-01-20

1551 High-throughput suppressor screens unveil functional convergence of single-gene lysis proteins

Adler, B. A.; Chamakura, K.; Carion, H.; Krog, J.; Deutschbauer, A. M.; Young, R. F.; Mutalik, V. K.; Arkin, A. P.

10.1101/2022.01.20.477139 — microbiology — Posted on 2022-01-20

1552 First detection of SARS-CoV-2 infection in Canadian wildlife identified in free-ranging white-tailed deer (Odocoileus virginianus) from southern Quebec, Canada

Kotwa, J. D.; Masse, A.; Gagnier, M.; Aftanas, P.; Blais-Savoie, J.; Bowman, J.; Buchanan, T.; Chee, H.-Y.; Dibernardo, A.; Kruczkiewicz, P.; Nirmalarajah, K.; Soos, C.; Yip, L.; Lindsay, L. R.; Lung, O.; Pickering, B.; Mubareka, S.

10.1101/2022.01.20.476458 — microbiology — Posted on 2022-01-21

1553 The CRISPR-Cas System differentially regulates surface-attached and pellicle-biofilm in Salmonella enterica serovar Typhimurium

Marathe, S. A.; Sharma, N.; Das, A.; Raja, P.

10.1101/2022.01.20.477050 — microbiology — Posted on 2022-01-21

1554 Deep and superficial layers of the primary somatosensory cortex are critical for whisker-based texture discrimination in mice

Park, J. M.; Hong, Y. K.; Rodgers, C. C.; Dahan, J. B.; Harano, N.; Schmidt, E. R.; Bruno, R. M.

10.1101/2020.08.12.245381 — neuroscience — Posted on 2022-01-20

1555 Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function

Kearney, P. J.; Conklin, T.; Martin, G. E.; Lubec, G.; Melikian, H. E.

10.1101/2021.06.04.447129 — neuroscience — Posted on 2022-01-20

1556 Depletion of CD206+ Tumour Macrophages via a Peptide-Targeted Star-Shaped Polyglutamate Inhibits Tumourigenesis and Metastatic Dissemination in Breast Cancer Models

Lepland, A.; Malfanti, A.; Haljasorg, U.; Asciutto, E.; Pickholz, M.; Bringas, M.; Dordevic, S.; Salumae, L.; Peterson, P.; Teesalu, T.; Vicent, M. J.; Scodeller, P.

10.1101/2021.12.29.474487 — cancer biology — Posted on 2022-01-20

1557 Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer

Vlaar, J.; Borgman, A.; Kalkhoven, E.; Westland, D.; Besselink, N.; Shale, C.; Faltas, B. M.; Priestley, P.; Kuijk, E.; Cuppen, E.

10.1101/2021.11.09.468005 — cancer biology — Posted on 2022-01-20

1558 Septin-Mediated Mechanobiological Reprogramming of T Cell Transmigration and 3D Motility

Zhovmer, A. S.; Manning, A.; Smith, C.; Vishweshwarayah, Y.; Wang, J.; Saez, P. J.; Ma, X.; Cartagena-Rivera, A. X.; Singh, R. K.; Dokholyan, N. V.; Tabdanov, E. D.

10.1101/2022.01.18.476840 — biophysics — Posted on 2022-01-20

1559 Unveiling molecular interactions that stabilize bacterial adhesion pili

Dahlberg, T.; Baker, J. L.; Bullitt, E.; Andersson, M.

10.1101/2022.01.20.477034 — biophysics — Posted on 2022-01-20

1560 A dynamical systems treatment of transcriptomic trajectories in hematopoiesis

Freedman, S. L.; Xu, B.; Goyal, S.; Mani, M.

10.1101/2021.05.03.442465 — biophysics — Posted on 2022-01-20

1561 Controlled adhesion, membrane pinning and vesicle transport by Janus particles

Ewins, E. J.; Han, K.; Bharti, B.; Robinson, T.; Velev, O. D.; Dimova, R.

10.1101/2022.01.19.474912 — biophysics — Posted on 2022-01-20

1562 Identifying interactions in omics data for clinical biomarker discovery

Christensen, N. J.; Demharter, S.; Machado, M.; Pedersen, L.; Salvatore, M.; Stentoft-Hansen, V.; Triana Iglesias, M.

10.1101/2022.01.14.475226 — bioinformatics — Posted on 2022-01-20

1563 Targeting SARS-CoV-2 infection through CAR T cells and bispecific T cell engagers

Dogan, M.; Kozhaya, L.; Placek, L.; Karabacak, F.; Yigit, M.; Unutmaz, D.

10.1101/2022.01.19.476940 — bioengineering — Posted on 2022-01-20

1564 Spatially resolved profiling of protein conformation and interactions by biocompatible chemical cross-linking in living cells

Zhao, L.; Zhao, Q.; An, Y.; Gao, H.; Zhang, W.; Gong, Z.; Liu, X.; Zhao, B.; Liang, Z.; Tang, C.; Zhang, L.; Zhang, Y.

10.1101/2022.01.20.476705 — biochemistry — Posted on 2022-01-20

1565 Exo-Enzymatic Cell-Surface Glycan Labeling for Capturing Glycan-Protein Interactions through Photo-Crosslinking

Babulic, J. L.; Capicciotti, C. J.

10.1101/2022.01.20.477088 — biochemistry — Posted on 2022-01-20

1566 Microtubule-Inspired Functionalization of Carbon Nanotubes: A Biomimetic Carrier Design

Barcelos, K.; Alisaraie, L.

10.1101/2022.01.20.477082 — biochemistry — Posted on 2022-01-20

1567 SUMM4 biochemically complex couples insulator function and DNA replication timingcontrol

Andreyeva, E. N.; Emelyanov, A. V.; Nevil, M.; Sun, L.; Vershilova, E.; Hill, C. A.; Keogh, M. C.; Duronio, R. J.; Skoultchi, A. I.; Fyodorov, D. V.

10.1101/2021.10.02.462895 — biochemistry — Posted on 2022-01-20

1568 DNA Strand Breaks and Gaps Target Retroviral Binding and Integration

Senavirathne, G.; Gardner, A.; London, J.; Fishel, R.; Yoder, K. E.

10.1101/2021.11.17.469012 — biochemistry — Posted on 2022-01-20

1569 How a Formate Dehydrogenase Responds to Oxygen: Unexpected O2 Insensitivity of an Enzyme Harboring Tungstopterin, Selenocysteine, and Clusters.

Graham, J. E.; Niks, D.; Zane, G. M.; Gui, Q.; Hom, K.; Hille, R.; Wall, J. D.; Raman, C. S.

10.1101/2022.01.18.476765 — biochemistry — Posted on 2022-01-20

1570 Leveraging a surrogate outcome to improve inference on a partially missing target outcome

McCaw, Z. R.; Gaynor, S. M.; Sun, R.; Lin, X.

10.1101/2020.11.29.403063 — genetics — Posted on 2022-01-20

1571 Whole genome analysis sheds light on the genetic origin of Huns, Avars and conquering Hungarians

Maroti, Z.; Neparaczki, E.; Schutz, O.; Maar, K.; Varga, G. I. B.; Kovacs, B.; Kalmar, T.; Nyerki, E.; Nagy, I.; Latinovics, D.; Tihanyi, B.; Marcsik, A.; Palfi, G.; Bernert, Z.; Gallina, Z.; Horvath, C.; Varga, S.; Kolto, L.; Rasko, I.; Nagy, P. L.; Balogh, C.; Zink, A.; Maixner, F.; Gotherstrom, A.; George, R.; Szalontai, C.; Szenthe, G.; Gall, E.; Kiss, A. P.; Racz, Z.; Gulyas, B.; Kovacsoczy, B. N.; Gaal, S. S.; Tomka, P.; Torok, T.

10.1101/2022.01.19.476915 — genetics — Posted on 2022-01-20

1572 Close kin dyads indicate intergenerational dispersal and barriers

Schmidt, T. L.; ELFEKIH, S.; Cao, L.-J.; Wei, S.-J.; Al-Fageeh, M.; Nassar, M.; Al-Malik, A.; Hoffmann, A. A.

10.1101/2022.01.18.476819 — genetics — Posted on 2022-01-20

1573 Facilitation and biodiversity jointly drive mutualistic networks

Losapio, G.; Norton Hasday, E.; Espadaler, X.; Germann, C.; Ortiz-Sanchez, F. J.; Pont, A. C.; Sommaggio, D.; Schöb, C.

10.1101/2020.08.25.266346 — ecology — Posted on 2022-01-20

1574 Coupled myovascular expansion directs cardiac growth and regeneration

DeBenedittis, P.; Karpurapu, A.; Henry, A.; Thomas, M. C.; McCord, T.; Brezitski, K.; Prasad, A.; Kobayashi, Y.; Shah, S.; Kontos, C.; TATA, P. R.; Lumbers, R. T.; Karra, R.

10.1101/2021.01.20.425322 — developmental biology — Posted on 2022-01-20

1575 Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload

Shahzadi, S. K.; Marzook, H.; Qaisar, R.; Ahmad, F.

10.1101/2021.10.14.464350 — molecular biology — Posted on 2022-01-20

1576 RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses.

Zhang, L.; Rashad, S.; Zhou, Y.; Niizuma, K.; Tominaga, T.

10.1101/2022.01.18.476838 — molecular biology — Posted on 2022-01-20

1577 FoodMicrobionet v4: a large, integrated, open and transparent database for food bacterial communities

Parente, E.; Zotta, T.; Ricciardi, A.

10.1101/2022.01.19.476946 — microbiology — Posted on 2022-01-20

1578 Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response

Shalamova, L.; Felgenhauer, U.; Schaubmar, A. R.; Buettner, K.; Widera, M.; Ciesek, S.; Weber, F.

10.1101/2022.01.20.476754 — microbiology — Posted on 2022-01-20

1579 Genomic library of Bordetella

Bridel, S.; Bouchez, V.; Hauck, S.; Brancotte, B.; Armatys, N.; Landier, A.; Muhle, E.; Guillot, S.; Toubiana, J.; Maiden, M. C.; Jolley, K. A.; Brisse, S.

10.1101/2022.01.20.475763 — microbiology — Posted on 2022-01-20

1580 High abundance of transcription regulators compacts the nucleoid in Escherichia coli

Yilmaz, C.; Schnetz, K.

10.1101/2022.01.19.477023 — microbiology — Posted on 2022-01-20

1581 Evidence of antibodies against SARS-CoV-2 in wild mustelids from Brittany (France)

Davoust, B.; Guerin, P.; Orain, N.; Fligny, C.; Flirden, F.; Fenollar, F.; Mediannikov, O.; Edouard, S.

10.1101/2022.01.20.477038 — microbiology — Posted on 2022-01-20

1582 Hurricane Harvey Impacts on Water Quality and Microbial Communities in Houston, TX Waterbodies

LaMontagne, M. G.; Zhang, Y.; Guillen, G. J.; Gentry, T. J.; Allen, M. S.

10.1101/2022.01.20.476661 — microbiology — Posted on 2022-01-20

1583 Longitudinal Assessment of SARS-CoV-2 Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multi-Cytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

Lin, J.; Law, R.; Korosec, C.; Zhou, C.; Koh, W. H.; Ghaemi, M. S.; Samaan, P.; Ooi, H. K.; Yue, F.-Y.; Gingras, A.-C.; Estacio, A.; Buccholz, M.; Cheatley, P. L.; Pavenski, K.; Mubareka, S.; McGeer, A.; Leis, J.; Heffernan, J. M.; Ostrowski, M.

10.1101/2022.01.18.476864 — immunology — Posted on 2022-01-20

1584 Alpha Oscillatory Activity Causally Linked to Working Memory Retention: Insights from Online Phase-corrected Closed-loop Transcranial Alternating Current Stimulation (tACS)

Chen, X.; Ma, R.; Zhang, W.; Wu, Q.; Yimiti, A.; Xia, X.; Cui, J.; Zeng, G. Q.; Bu, J.; Chen, Q.; Yu, N. X.; Wang, S.; Deng, Z.-D.; Sack, A. T.; Laughlin, M. M.; Zhang, X.

10.1101/2021.05.23.445322 — neuroscience — Posted on 2022-01-20

1585 Base editors for citrus gene editing

Huang, X.; Wang, Y.; Wang, N.

10.1101/2021.10.19.464826 — plant biology — Posted on 2022-01-20

1586 AI-based graptolite identification improves shale gas exploration

Niu, Z.-b.; Xu, H.-h.

10.1101/2022.01.17.476477 — paleontology — Posted on 2022-01-20

1587 Deep learning applications in single-cell omics data analysis

Erfanian, N.; Heydari, A. A.; Ianez, P.; Derakhshani, A.; Ghasemigol, M.; Farahpour, M.; Nasseri, S.; Safarpour, H.; Sahebkar, A.

10.1101/2021.11.26.470166 — bioinformatics — Posted on 2022-01-20

1588 H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeller function

Li, J.; Bergmann, L.; Rafael de Almeida, A.; Webb, K. M.; Gogol, M. M.; Voigt, P.; Liu, Y.; Liang, H.; Smolle, M. M.

10.1101/2021.02.26.432832 — biochemistry — Posted on 2022-01-20

1589 Biophysical Characterisation of Human LincRNA-p21 Sense and Antisense Alu Inverted Repeats

D'Souza, M.; Mrozowich, T.; Badmalia, M. D.; Geeraert, M.; Frederickson, A.; Henrickson, A.; Demeler, B.; Wolfinger, M. T.; Patel, T. R.

10.1101/2021.12.08.471813 — biochemistry — Posted on 2022-01-20

1590 The kinase inhibitor Palbociclib is a potent and specific RNA-binding molecule

Shortridge, M. D.; Vidalala, V.; Varani, G.

10.1101/2022.01.20.477126 — biochemistry — Posted on 2022-01-20

1591 MaxQuant and MSstats in Galaxy enable reproducible cloud-based analysis of quantitative proteomics experiments for everyone

Pinter, N.; Glätzer, D.; Fahrner, M.; Fröhlich, K.; Johnson, J.; Grüning, B. A.; Warscheid, B.; Drepper, F.; Schilling, O.; Föll, M. C.

10.1101/2022.01.20.477129 — biochemistry — Posted on 2022-01-20

1592 Dairy vs. beef production - expert views on welfare

Mandel, R.; Bracke, M. B. M.; Nicol, C. J.; Webster, J.; Gygax, L.

10.1101/2021.12.06.471462 — animal behavior and cognition — Posted on 2022-01-20

1593 Computation of Antigenicity Predicts SARS-CoV-2 Vaccine Breakthrough Variants

Hu, Y.-f.; Hu, J.-c.; Gong, H.-R.; Danchin, A.; Sun, R.; Chu, H.; Hung, I. F.-N.; Yuen, K. Y.; To, K. K.-W.; Zhang, B.-Z.; Yau, T.; Huang, J.-D.

10.1101/2022.01.19.477009 — evolutionary biology — Posted on 2022-01-20

1594 Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

Duty, J. A.; Kraus, T. A.; Zhou, H.; Zhang, Y.; Shaabani, N.; Yildiz, S.; Du, N.; Singh, A.; Miorin, L.; Li, D.; Stegman, K.; Ophir, S. I.; Cao, X.; Atanasoff, K.; Lim, R.; Kowdle, S. S.; Carreno, J. M.; Rivero-Nava, L.; Raskin, A.; Moreno, E.; Johnson, S.; Rathnasinghe, R.; Pai, C. I.; Kehrer, T.; Paz Cabral, E.; Jangra, S.; Healy, L. D.; Singh, G.; Warang, P.; Simon, V.; Sordillo, M. E.; van Bakel, H.; Liu, Y.; Sun, W.; Kerwin, L.; Palese, P.; Teijaro, J.; Schotsaert, M.; Krammer, F.; Bresson, D.; Garcia-Sastre, A.; Fu, Y.; Lee, B.; Powers, C.; Moran, T. M.; Ji, H.; Tortorella, D.; Allen, R.

10.1101/2022.01.19.476998 — microbiology — Posted on 2022-01-20

1595 Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells

Jacobi, A.; Tran, N.; Yan, W.; Benhar, I.; Tian, F.; Schaffer, R.; He, Z.; Sanes, J. R.

10.1101/2022.01.19.476970 — neuroscience — Posted on 2022-01-20

1596 PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos

Calvi, I.; Schwager, F.; Gotta, M.

10.1101/2022.01.19.476913 — cell biology — Posted on 2022-01-20

1597 Central role of Prominin-1 in lipid rafts during liver regeneration

Bahn, M.-S.; Yu, D.-M.; Lee, M.; Jo, S.-J.; Lee, J.-W.; Lee, H.; Kim, A.; Hong, J.-H.; Kim, J.-S.; Koo, S.-H.; Lee, J.-S.; Ko, Y.-G.

10.1101/2022.01.20.477032 — cell biology — Posted on 2022-01-20

1598 c-Fos protein shRNA blockade in the central amygdala nucleus interfere with rats emotional reactivity on behavioral and autonomic level

Robakiewicz, I.

10.1101/2022.01.18.476659 — neuroscience — Posted on 2022-01-20

1599 BIN1 regulates electrical activity and network synchronization in hiPSC-derived neurons

Saha, O.; Melo de Farias, A. R.; Pelletier, A.; Carrier, A.; Gadaut, J.; Landeira, B. M. S.; Guyot, K.; Vreulx, A.-C.; Amouyel, P.; Bonnefond, A.; Queiroz, C. M.; Kilinc, D.; Delahaye, F.; Lambert, J.-C.; Costa, M. R.

10.1101/2022.01.18.476601 — neuroscience — Posted on 2022-01-20

1600 Interplay between murine sex-biased gene expression and hepatic zonation revealed by single nucleus RNA sequencing

Goldfarb, C. N.; Karri, K.; Pyatkov, M.; Waxman, D. J.

10.1101/2022.01.18.476791 — systems biology — Posted on 2022-01-20

1601 Phenotypic Pliancy and the Breakdown of Epigenetic Polycomb Mechanisms

Lambros, L.; Sella, Y.; Bergman, A.

10.1101/2022.01.18.476783 — systems biology — Posted on 2022-01-20

1602 Physiological responses of plants to in vivo XRF radiation damage: insights from elemental, histochemical, anatomical and ultrastructural analyses

Montanha, G. S.; Marques, J. P. R.; Rodrigues, E. S.; Jones, M. W. M.; de Carvalho, H. W. P.

10.1101/2022.01.18.476760 — plant biology — Posted on 2022-01-20

1603 In Vitro and In Vivo Pathogenicity of A. alternata to Sugar beet and Assessment of Sensitivity to Fungicides

Haque, M. E.; Parvin, M. S.

10.1101/2022.01.15.476474 — plant biology — Posted on 2022-01-20

1604 Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

10.1101/2022.01.18.476775 — cancer biology — Posted on 2022-01-20

1605 Redefining the architecture of ferlin proteins: insights into multi-domain protein structure and function

Dominguez, M. J.; McCord, J. J.; Sutton, R. B.

10.1101/2022.01.18.476802 — biophysics — Posted on 2022-01-20

1606 SERM: a self-consistent deep learning solution forrapid and accurate gene expression recovery

Islam, M. T.; Wang, J.-Y.; Ren, H.; Li, X.; Khuzani, M. B.; Sang, S.; Yu, L.; Shen, L.; Zhao, W.; Xing, L.

10.1101/2022.01.18.476789 — bioinformatics — Posted on 2022-01-20

1607 Identification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry

Munden, A.; Wright, M.; Han, D.; Tirgar, R.; Plate, L.; Nordman, J.

10.1101/2022.01.18.476773 — biochemistry — Posted on 2022-01-20

1608 SAIBR: A simple, platform-independent method for spectral autofluorescence correction

Rodrigues, N. T. L.; Bland, T.; Borrego-Pinto, J.; Ng, K.; Hirani, N.; Gu, Y.; Foo, S.; Goehring, N. W.

10.1101/2022.01.19.476881 — cell biology — Posted on 2022-01-20

1609 Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types

van Zyl, T.; Yan, W.; McAdams, A.; Monavarfeshani, A.; Hageman, G. S.; Sanes, J. R.

10.1101/2022.01.19.476971 — cell biology — Posted on 2022-01-20

1610 Denoising diffusion weighted imaging data using convolutional neural networks

Cheng, H.; Vinci-Booher, S.; Wang, J.; Caron, B.; Wen, Q.; Newman, S.; Pestilli, F.

10.1101/2022.01.17.476708 — neuroscience — Posted on 2022-01-20

1611 Expansion and Adaptive Evolution of the mTERF Gene Family in Plants

Zhao, Y.; Cai, M.; Luo, M.; Zhang, J.; Li, Y.; Zhang, X.; Yue, B.; Xiao, H.; Zhao, J.; Zheng, Y.; Qiu, F.

10.1101/2022.01.18.476766 — plant biology — Posted on 2022-01-20

1612 Using the UniFrac metric on Whole Genome Shotgun data

Wei, W.; Koslicki, D.

10.1101/2022.01.17.476629 — bioinformatics — Posted on 2022-01-20

1613 Honey bee flights under ethanol-exposure show changes in body and wing kinematics

Ahmed, I.; Abramson, C. I.; Faruque, I. A.

10.1101/2022.01.18.476777 — animal behavior and cognition — Posted on 2022-01-20

1614 STAT3 regulates cytokine production downstream of TNFR1 in part by inducing expression of TNFAIP3/A20

Antonia, R. J.; Karelehto, E.; Toriguchi, K.; Matli, M.; Warren, R. S.; Pfeffer, L. M.; Donner, D. B.

10.1101/2022.01.19.476699 — cell biology — Posted on 2022-01-20

1615 Mitigation of the age-dependent decline in mitochondrial genome integrity

Tsai, P.-I.; Korotkevich, E.; O'Farrell, P. H.

10.1101/2022.01.18.476860 — cell biology — Posted on 2022-01-20

1616 Biochemistry and nanomechanical properties of human colon cells upon simvastatin, lovastatin and mevastatin supplementations - Raman imaging and AFM studies

Beton, K.; Brozek-Pluska, B.

10.1101/2022.01.19.476934 — cell biology — Posted on 2022-01-20

1617 A local translation program regulates centriole amplification in the airway epithelium

Liu, H.; Li, H.; Jiang, Z.; Jin, S.; Song, R.; Yang, Y.; Li, J.; Huang, J.; Zhang, X.; Dong, X.; Que, J.; Mori, M.; Fritzler, M. J.; He, L.; Cardoso, W. V.; Lu, J.

10.1101/2022.01.18.476821 — cell biology — Posted on 2022-01-20

1618 CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia

ALLOUCH, A.; VOISIN, L.; ZHANG, Y.; SYED, R.; LECLUSE, Y.; CALVO, J.; Selimoglu-Buet, D.; DE BOTTON, S.; LOUACHE, F.; PFLUMIO, F.; SOLARY, E.; PERFETTINI, j.-l.

10.1101/2022.01.18.476736 — immunology — Posted on 2022-01-20

1619 A bivalent EBV vaccine induces neutralizing antibodies that block B and epithelial cell infection and confer immunity in humanized mice

Wei, C.-J.; Bu, W.; Nguyen, L. A.; Batchelor, J. D.; Kim, J.; Pittaluga, S.; Fuller, J. R.; Nguyen, H.; Chou, T.-H.; Cohen, J.; Nabel, G. J.

10.1101/2022.01.18.476774 — immunology — Posted on 2022-01-20

1620 Exploiting Color Space Geometry for Visual Stimulus Design across Animals

Christenson, M. P.; Mousavi, S. N.; Heath, S. L.; Behnia, R.

10.1101/2022.01.17.476640 — neuroscience — Posted on 2022-01-20

1621 pyNeurode: a real-time neural signal processing framework

Tam, W. K.; Nolan, M. F.

10.1101/2022.01.18.476764 — neuroscience — Posted on 2022-01-20

1622 Sensory system-specific associations between brain structure and balance

Hupfeld, K. E.; McGregor, H. R.; Hass, C. J.; Pasternak, O.; Seidler, R.

10.1101/2022.01.17.476654 — neuroscience — Posted on 2022-01-20

1623 The cross-domain functional organisation of posterior lateral temporal cortex: Insights from ALE meta-analyses of seven cognitive domains spanning 9515 participants

Hodgson, V. J.; Lambon Ralph, M.; Jackson, R. L.

10.1101/2022.01.18.476749 — neuroscience — Posted on 2022-01-20

1624 Walking elicits global brain activity in Drosophila

Aimon, S.; Cheng, K. Y.; Gjorgjieva, J.; Grunwald Kadow, I. C.

10.1101/2022.01.17.476660 — neuroscience — Posted on 2022-01-20

1625 ABLE: Automated Brain Lines Extraction Based on Laplacian Surface Collapse

Fernandez-Pena, A.; Martin de Blas, D.; Navas-Sanchez, F. J.; Marcos-Vidal, L.; M. Gordaliza, P.; Santonja, J.; Janssen, J.; Carmona, S.; Desco, M.; Aleman-Gomez, Y.

10.1101/2022.01.18.476370 — neuroscience — Posted on 2022-01-20

1626 Selective inhibition of goal-directed actions in the mesencephalic locomotor region

Gut, N. K.; Yilmaz, D.; Kondabolu, K.; Huerta-Ocampo, I.; Mena-Segovia, J.

10.1101/2022.01.18.476772 — neuroscience — Posted on 2022-01-20

1627 Specialization in somatostatin subnetworks in sensory and association cortex

Khoury, C. F.; Fala, N. G.; Runyan, C. A.

10.1101/2022.01.18.476770 — neuroscience — Posted on 2022-01-20

1628 Phenotypic deconvolution in heterogeneous cancer cell populations using drug screening data

Köhn-Luque, A.; Myklebust, E. M.; Tadele, D. S.; Giliberto, M.; Noory, J.; Harivel, E.; Arsenteva, P.; Mumenthaler, S. M.; Schjesvold, F.; Tasken, K.; Enserink, J. M.; Leder, K.; Frigessi, A.; Foo, J.

10.1101/2022.01.17.476604 — cancer biology — Posted on 2022-01-20

1629 ScrepYard: an online resource for disulfide-stabilised tandem repeat peptides

Liu, J.; Maxwell, M. J.; Cuddihy, T.; Crawford, T.; Bassetti, M.; Hyde, C.; Undheim, E. A. B.; Mobli, M.

10.1101/2022.01.17.476686 — bioinformatics — Posted on 2022-01-20

1630 Resistor: an algorithm for predicting resistance mutations using Pareto optimization over multistate protein design and mutational signatures

Guerin, N.; Kaserer, T.; Donald, B. R.

10.1101/2022.01.18.476733 — bioinformatics — Posted on 2022-01-20

1631 Encoding sensing functions into material interface for a rationally engineered integrated electrochemical liquid biopsy

Zhang, Y.; Zhu, H.; Ying, Z.; Gao, X.; Chen, W.; Zhan, Y.; Feng, L.; Liu, C.-c.; Dai, Y.

10.1101/2022.01.17.476350 — bioengineering — Posted on 2022-01-20

1632 Validity and reliability of Kinect v2 for quantifying upper body kinematics during seated reaching

FAITY, G.; Mottet, D.; Froger, J.

10.1101/2022.01.18.476737 — bioengineering — Posted on 2022-01-20

1633 Chronic social stress induces isolated deficits in reward anticipation on a neuroeconomic foraging task

Durand-de Cuttoli, R.; Martinez-Rivera, F. J.; Li, L.; Minier-Toribio, A.; Russo, S. J.; Nestler, E. J.; Sweis, B. M.

10.1101/2022.01.17.476514 — animal behavior and cognition — Posted on 2022-01-20

1634 Machine learning guided signal enrichment for ultrasensitive plasma tumor burden monitoring

Widman, A. J.; Shah, M.; Ogaard, N.; Khamnei, C. C.; Frydendahl, A.; Deshpande, A.; Arora, A.; Zhang, M.; Halmos, D.; Bass, J.; Langanay, T.; Rajagopalan, S.; Steinsnyder, Z.; Liao, W.; Rasmussen, M. H.; Jensen, S. O.; Nors, J.; Therkildsen, C.; Sotelo, J.; Brand, R.; Shah, R. H.; Cheng, A. P.; Maher, C.; Spain, L.; Krause, K.; Frederick, D. T.; Malbari, M. S.; Marton, M.; Manaa, D.; Winterkorn, L.; Callahan, M. K.; Boland, G.; Wolchok, J. D.; Saxena, A.; Turajlic, S.; Imielinski, M.; Berger, M. F.; Altorki, N. K.; Postow, M. A.; Robine, N.; Andersen, C. L.; Landau, D. A.

10.1101/2022.01.17.476508 — genomics — Posted on 2022-01-20

1635 Assessing the response to genomic selection by simulation

Buntaran, H.; Berna-Vasquez, A. M.; Gordillo, A.; Wimmer, V.; Sahr, M.; Piepho, H.-P.

10.1101/2022.01.17.476687 — genetics — Posted on 2022-01-20

1636 Espalier: Efficient tree reconciliation and ARG reconstruction using maximum agreement forests

Rasmussen, D. A.; Guo, F.

10.1101/2022.01.17.476639 — evolutionary biology — Posted on 2022-01-20

1637 Higher aboveground carbon stocks in mixed-species planted forests than monocultures - a meta-analysis

Warner, E.; Cook-Patton, S. C.; Lewis, O. T.; Brown, N.; Koricheva, J.; Eisenhauer, N.; Ferlian, O.; Gravel, D.; Hall, J. S.; Jactel, H.; Mayoral, C.; Meredieu, C.; Messier, C.; Paquette, A.; Parker, W. C.; Potvin, C.; Reich, P. B.; Hector, A.

10.1101/2022.01.17.476441 — ecology — Posted on 2022-01-20

1638 Mitochondrial diversity in the ribbed mussel, Geukensia demissa, relative to high marsh plant diversity at the southern edge of the distribution

Francis, I. G.; Wares, J. P.

10.1101/2022.01.16.476515 — ecology — Posted on 2022-01-20

1639 Assessing the impact of roadkill on the persistence of wildlife populations: a case study on the giant anteater

Ascensao, F.; Desbiez, A.

10.1101/2022.01.18.476626 — ecology — Posted on 2022-01-20

1640 Olive mill wastewater extract as a potential mosquito larvicide

Halabi, M.; Silberbush, A.; Azaizeh, H.; Shahar, B.; Kurzbaum, E.

10.1101/2022.01.18.476713 — ecology — Posted on 2022-01-20

1641 Fat2 polarizes the WAVE complex in trans to align cell protrusions for collective migration

Williams, A. M.; Donoughe, S.; Munro, E.; Horne-Badovinac, S.

10.1101/2022.01.17.476701 — developmental biology — Posted on 2022-01-20

1642 T cell response following anti COVID-19 BNT162b2 vaccination is maintained against the SARS-CoV-2 Omicron B.1.1.529 variant of concern

Cohen, H.; Rotem, S.; Elia, U.; Bilinsky, G.; Levy, I.; Chitlaru, T.; Bar-Haim, E.

10.1101/2022.01.19.476497 — immunology — Posted on 2022-01-20

1643 Region-specific CREB function regulates distinct forms of regret associated with resilience versus susceptibility to chronic stress

Durand-de Cuttoli, R.; Martinez-Rivera, F. J.; Li, L.; Minier-Toribio, A.; Cathomas, F.; Holt, L. M.; Yasmin, F.; Elhassa, S. O.; Shaikh, J. F.; Ahmed, S.; Russo, S. J.; Nestler, E. J.; Sweis, B. M.

10.1101/2022.01.17.476637 — neuroscience — Posted on 2022-01-20

1644 A Multisite and Multimodal Comparative Study of Cerebellar Connectome Between Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders

Yang, Y.; Li, J.; Li, Z.; Liu, Y.; Wang, J.

10.1101/2022.01.16.476492 — neuroscience — Posted on 2022-01-20

1645 Membrane Stretch Gates NMDA Receptors

Belin, S.; Maki, B. A.; Catlin, J.; Rein, B. A.; Popescu, G. K.

10.1101/2022.01.17.476675 — neuroscience — Posted on 2022-01-20

1646 Modified viral-genetic mapping reveals local and global connectivity relationships of ventral tegmental area dopamine cells

Beier, K.

10.1101/2022.01.18.476718 — neuroscience — Posted on 2022-01-20

1647 Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications

Rust, R.; Weber, R. Z.; Generali, M.; Kehl, D.; Bodenmann, C.; Uhr, D.; Wanner, D.; Zuercher, K. J.; Saito, H.; Hoerstrup, S. P.; Nitsch, R. M.; Tackenberg, C.

10.1101/2022.01.18.476253 — neuroscience — Posted on 2022-01-20

1648 Integration of heterogeneous biological data in multiscale mechanistic model calibration: application to lung adenocarcinoma

Palgen, J.-L.; Perrillat-Mercerot, A.; Ceres, N.; Peyronnet, E.; Coudron, M.; Tixier, E.; Illigens, B. M. W.; Bosley, J.; L'Hostis, A.; Monteiro, C.

10.1101/2022.01.17.476676 — systems biology — Posted on 2022-01-20

1649 Designing multi-epitope based peptide vaccine targeting spike protein SARS-CoV-2 B1.1.529 (Omicron) variant using computational approaches.

Parmar, M.; Thumar, R.; Sheth, J.; Patel, D.

10.1101/2021.12.23.473990 — bioinformatics — Posted on 2022-01-20

1650 CView: A network based tool for enhanced alignment visualization

Linheiro, R.; Sabatino, S.; Lobo, D.; Archer, J.

10.1101/2022.01.17.476623 — bioinformatics — Posted on 2022-01-20

1651 Sequencing of individual barcoded cDNAs on Pacific Biosciences and Oxford Nanopore reveals platform-specific error patterns

Mikheenko, A.; Prjibelski, A. D.; Joglekar, A.; Tilgner, H. U.

10.1101/2022.01.17.476636 — bioinformatics — Posted on 2022-01-20

1652 Joint embedding of biological networks for cross-species functional alignment

Li, L.; Dannenfelser, R.; Zhu, Y.; Hejduk, N.; Segarra, S.; Yao, V.

10.1101/2022.01.17.476697 — bioinformatics — Posted on 2022-01-20

1653 A deep CNN framework for neural drive estimation from HD-EMG across contraction intensities and joint angles

Wen, Y.; Kim, S. J.; Avrillon, S.; Levine, J. T.; Hug, F.; Pons, J. L.

10.1101/2022.01.17.476688 — bioengineering — Posted on 2022-01-20

1654 Serological screening suggests single SARS-CoV-2 spillover events to cattle

Wernike, K.; Boettcher, J.; Amelung, S.; Albrecht, K.; Gaertner, T.; Donat, K.; Beer, M.

10.1101/2022.01.17.476608 — microbiology — Posted on 2022-01-20

1655 Regulators of proteostasis are translationally repressed in fibroblasts from sporadic and LRRK2-G2019S Parkinson's patients

Flinkman, D.; Hong, Y.; Deshpande, P.; Peltonen, S.; Kaasinen, V.; James, P.; Coffey, E.

10.1101/2022.01.17.476095 — neuroscience — Posted on 2022-01-20

1656 The formal demography of kinship IV: Two-sex models

Caswell, H.

10.1101/2022.01.17.476606 — ecology — Posted on 2022-01-20

1657 Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling

Brownfield, D. G.; Diaz de Arce, A.; Ghelfi, E.; Gillich, A.; Desai, T. J.; Krasnow, M. A.

10.1101/2022.01.17.476560 — developmental biology — Posted on 2022-01-20

1658 Cell-Type Specific Profiling of Histone Post-Translational Modifications in the Adult Mouse Striatum

Carpenter, M. D.; Fischer, D. K.; Zhang, S.; Bond, A. M.; Czarnecki, K. S.; Woolf, M. T.; Song, H.; Heller, E. A.

10.1101/2022.01.17.476614 — neuroscience — Posted on 2022-01-20

1659 A whole-brain 3D myeloarchitectonic atlas: mapping the Vogt-Vogt legacy to the cortical surface

Foit, N. A.; Yung, S.; Lee, H. M.; Bernasconi, A.; Bernasconi, N.; Hong, S.-J.

10.1101/2022.01.17.476369 — neuroscience — Posted on 2022-01-20

1660 A systematic evaluation of yeast sample preparation protocols for spectral identifications, proteome coverage and post-isolation modifications

den Ridder, M.; Knibbe, E.; van den Brandeler, W.; Daran-Lapujade, P.; Pabst, M.

10.1101/2022.01.17.476533 — systems biology — Posted on 2022-01-20

1661 Improvements in estimating bioaccumulation metrics in the light of toxicokinetics models and Bayesian inference

Ratier, A.; Lopes, C.; Charles, S.

10.1101/2022.01.17.476613 — pharmacology and toxicology — Posted on 2022-01-20

1662 Contractility-induced self-organization of smooth muscle cells: from multilayer cell sheets to dynamic three-dimensional clusters

Wang, X.; Gonzalez-Rodriguez, D.; Vourc'h, T.; Silberzan, P.; Barakat, A.

10.1101/2022.01.17.476602 — biophysics — Posted on 2022-01-20

1663 Symbolic Kinetic Models in Python (SKiMpy): Intuitive modeling of large-scale biological kinetic models

Weilandt, D. R.; Salvy, P.; Masid, M.; Fengos, G.; Denhardt Eriksson, R.; Hosseini, Z.; Hatzimanikatis, V.

10.1101/2022.01.17.476618 — bioinformatics — Posted on 2022-01-20

1664 Combinatorial selection of biomarkers to optimize gene signatures in diagnostics and single cell applications

Ferrari, I.; Mazzara, S.; Grifantini, R.; Abrignani, S.; Bombaci, M.; Rossi, R. L.

10.1101/2022.01.17.476603 — bioinformatics — Posted on 2022-01-20

1665 Impact of ionizing radiation on the environmental microbiomes of Chernobyl wetlands

Videvall, E.; Burraco, P.; Orizaola, G.

10.1101/2022.01.17.476627 — ecology — Posted on 2022-01-20

1666 Predator-prey interactions in a warming world: the critical role of cold tolerance

Ge, X.; Griswold, C. K.; Newman, J. A.

10.1101/2022.01.17.476522 — ecology — Posted on 2022-01-20

1667 Isolating perceptual biases caused by trial history during auditory categorization

Duque, D.; de la Rocha, J.

10.1101/2022.01.17.476581 — neuroscience — Posted on 2022-01-20

1668 Re-routing metabolism by the mitochondrial pyruvate carrier inhibitor MSDC-0160 attenuates neurodegeneration in a rat model of Parkinson's disease

Mallet, D.; Goutaudier, R.; Barbier, E.; Carnicella, S.; Colca, J.; Fauvelle, F.; Boulet, S.

10.1101/2022.01.17.476616 — neuroscience — Posted on 2022-01-20

1669 Increasing discovery rates in preclinical research through optimised statistical decision criteria

Danziger, M.; Dirnagl, U.; Toelch, U.

10.1101/2022.01.17.476585 — scientific communication and education — Posted on 2022-01-20

1670 Matrix viscoelasticity controls spatio-temporal tissue organization

Elosegui-Artola, A.; Gupta, A.; Najibi, A. J.; Seo, B. R.; Garry, R.; Tringides, C. M.; de Lazaro, I.; Darnell, M.; Gu, W.; Zhou, Q.; Weitz, D.; Mahadevan, L.; Mooney, D.

10.1101/2022.01.19.476771 — biophysics — Posted on 2022-01-20

1671 An evolutionary algorithm for inverse RNA folding inspired by Levy flights

Nono Saha, C. M.; Smerlak, M.

10.1101/2022.01.17.476593 — bioinformatics — Posted on 2022-01-20

1672 SNP calling for the Illumina Infinium Omni5-4 SNP BeadChip kit using the butterfly method

Andersen, M. M.; Christiansen, S. N.; Andersen, J. D.; Eriksen, P. S.; Morling, N.

10.1101/2022.01.17.476594 — bioinformatics — Posted on 2022-01-20

1673 Identifying interactions in omics data for clinical biomarker discovery

Christensen, N. J.; Demharter, S.; Triana Iglesias, M.; Machado, M.; Pedersen, L.; Salvatore, M.; Stentoft-Hansen, V.

10.1101/2022.01.14.475226 — bioinformatics — Posted on 2022-01-20

1674 Probabilistic quotient's work and pharmacokinetics' contribution: countering size effect in metabolic time series measurements

Gotsmy, M.; Brunmair, J.; Bueschl, C.; Gerner, C.; Zanghellini, J.

10.1101/2022.01.17.476591 — bioinformatics — Posted on 2022-01-20

1675 Plausible pathway for a host-parasite molecular replication network to increase its complexity through Darwinian evolution

Kamiura, R.; Mizuuchi, R.; Ichihashi, N.

10.1101/2022.01.17.476531 — evolutionary biology — Posted on 2022-01-20

1676 Region Selective Cortical Control Of The Thalamic Reticular Nucleus

Hadinger, N.; Bosz, E.; Toth, B.; Vantomme, G.; Luthi, A.; Acsady, L.

10.1101/2022.01.17.476335 — neuroscience — Posted on 2022-01-20

1677 Robust, long-term video EEG monitoring in a porcine model of post-traumatic epilepsy.

Martinez Ramirez, L.; Slate, A.; Price, G. G.; Duhaime, A.-C.; Staley, K. J.; Costine-Bartell, B. A.

10.1101/2022.01.17.476340 — neuroscience — Posted on 2022-01-20

1678 Metastability, fractal scaling, and synergistic information processing: what phase relationships reveal about intrinsic brain activity

Hancock, F.; Cabral, J.; Luppi, A.; Rosas, F.; Mediano, P.; Dipasquale, O.; Turkheimer, F. E.

10.1101/2022.01.17.476583 — neuroscience — Posted on 2022-01-20

1679 Structural insights into the galanin receptors signaling

Zheng, S.; Jiang, W.

10.1101/2022.01.17.476689 — neuroscience — Posted on 2022-01-20

1680 Royal knifefish generate powerful suction feeding through large neurocranial elevation and high muscle power output

Li, E. Y.; Kaczmarek, E. B.; Olsen, A.; Brainerd, E. L.; Camp, A. L.

10.1101/2022.01.17.476172 — zoology — Posted on 2022-01-20

1681 Acclimation of phenology relieves leaf longevity constraints in deciduous forests

Marques, L.; Hufkens, K.; Bigler, C.; Crowther, T. W.; Zohner, C. M.; Stocker, B. D.

10.1101/2022.01.17.476561 — ecology — Posted on 2022-01-20

1682 Long dsRNA mediated RNA interference (dsRNAi) is antiviral in interferon competent mammalian cells

Semple, S. L.; Jacob, R. A.; Mossman, K. L.; DeWitte-Orr, S. J.

10.1101/2022.01.14.476298 — immunology — Posted on 2022-01-20

1683 Structural changes after early life adversity in rodents: a systematic review with meta-analysis

Joels, M.; Kraaijenvanger, E.; Sarabdjitsingh, R. A.; Bonapersona, V.

10.1101/2022.01.17.476580 — neuroscience — Posted on 2022-01-20

1684 Evolutionary PTEN Gene Divergence Underpins the Remodeling of Plant Vacuolar Compartments

Gujas, B.; Champeyroux, C.; Hunkeler, A.; Robinson, E.; Blanco-Tourinan, N.; Dias Cruz, T. M.; Van Durme, M.; Nowack, M. K.; Rodriguez-Villalon, A.

10.1101/2022.01.18.476728 — plant biology — Posted on 2022-01-20

1685 Scale Bar of Aging Trajectories for Screening Personal Rejuvenation Treatments

Shen, X.; Wu, B.; Jiang, W.; Li, Y.; Zhang, Y.; Zhao, K.; Nie, N.; Gong, L.; Liu, Y.; Zou, X.; Liu, J.; Jin, J.; Hongwei, O.

10.1101/2022.01.17.476558 — bioengineering — Posted on 2022-01-20

1686 Intramolecular carbon isotope signals reflect metabolite allocation in plants

Wieloch, T.; Sharkey, T. D.; Werner, R. A.; Schleucher, J.

10.1101/2021.06.25.449710 — plant biology — Posted on 2022-01-20

1687 Long read sequencing reveals sequential complex rearrangements driven by Hepatitis B virus integration

Wang, S.; Lin, J.; Yang, X.; Li, Z.; Xu, T.; Jia, P.; Wang, T.; Wang, B.; Hu, L.; Ye, K.

10.1101/2021.12.09.471697 — genomics — Posted on 2022-01-20

1688 Prime Editing Efficiency and Fidelity are Enhanced in the Absence of Mismatch Repair

Ferreira da Silva, J.; Oliveira, G.; Arasa-Verge, E.; Kagiou, C.; Moretton, A.; Thimelthaler, G.; Jiricny, J.; Loizou, J. I.

10.1101/2021.09.30.462548 — molecular biology — Posted on 2022-01-20

1689 Distribution, molecular evolution, and mutational scanning of the anti-CRISPR family AcrIF7 reveal conservation, key residues for the protein function and a putative alternative binding mode to Cas8f

Figueroa, W.; Cazares, A.; Cazares, D.; Wu, Y.; De la Cruz, A.; Welch, M.; Kameyama, L.; Nobrega, F.; Guarneros, G.

10.1101/2021.06.27.450086 — microbiology — Posted on 2022-01-20

1690 The two-component system ChvGI maintains cell envelope homeostasis in Caulobacter crescentus

Quintero-Yanes, A.; Coppine, J.; Mayard, A.; Hallez, R.

10.1101/2022.01.18.476748 — microbiology — Posted on 2022-01-20

1691 Macroscopic chemical to electrical signal converter in microbial communities

Wabnik, K.; Garcia Navarrete, M.; Avdovic, M.; Perez Garcia, S.; Ruiz Sanchis, D.

10.1101/2022.01.19.476902 — synthetic biology — Posted on 2022-01-20

1692 A modular RNA interference system for multiplexed gene regulation

Dwijayanti, A.; Storch, M.; Stan, G.-B.; Baldwin, G. S.

10.1101/2019.12.12.873844 — synthetic biology — Posted on 2022-01-20

1693 The accuracy of protein structures in solution determined by AlphaFold and NMR

Fowler, N. J.; Williamson, M. P.

10.1101/2022.01.18.476751 — biophysics — Posted on 2022-01-20

1694 A comprehensive library of canonical and non-canonical MHC class I antigens for cancer vaccine development.

Bedran, G.; Wang, T.; Pankanin, D.; Weke, K.; Laird, A.; Battail, C.; Zanzotto, F. M.; Pesquita, C.; Axelson, H.; Rajan, A.; Harrison, D. J.; Palkowski, A.; Pawlik, M.; Parys, M.; O'Neill, R.; Brennan, P. M.; Symeonides, S.; Goodlett, D. R.; Litchfield, K.; Fahraeus, R.; Hupp, T. R.; Kote, S.; Alfaro, J. A.

10.1101/2022.01.13.475872 — bioinformatics — Posted on 2022-01-20

1695 Ubiquitinome analysis of articular cartilage post mechanical injury reveals a differential ubiquitination pattern of a subset of DUBs and proteins linked to the ERAD cellular response

Kaokhum, N.; Pinto-Fernandez, A.; Wilkinson, J. M.; Kessler, B. M.; Ismail, H.

10.1101/2022.01.19.476879 — biochemistry — Posted on 2022-01-20

1696 Structural features of Dnase1L3 responsible for serum antigen clearance

McCord, J. J.; Engavale, M.; Masoumzadeh, E.; Villarreal, J.; Mapp, B.; Latham, M. P.; Keyel, P. A.; Sutton, R. B.

10.1101/2022.01.19.476959 — biochemistry — Posted on 2022-01-20

1697 Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex

Foucher, A.-E.; Touat-Todeschini, L.; Juarez-Martinez, A. B.; Laroussi, H.; Karczewski, C.; Acajjaoui, S.; Soler Lopez, M.; Cusack, S.; Mackereth, C. D.; Verdel, A.; Kadlec, J.

10.1101/2022.01.19.476877 — biochemistry — Posted on 2022-01-20

1698 Polycistronic baculovirus expression of SUGT1 enables high-yield production of recombinantleucine-rich repeat proteins and protein complexes

Snead, K.; Wall, V.; Ambrose, H.; Esposito, D.; Drew, M.

10.1101/2022.01.19.476911 — biochemistry — Posted on 2022-01-20

1699 Probing the proton release by Photosystem II in the S1 to S2 high-spin transition

Boussac, A.; sugiura, m.; sellés, j.

10.1101/2022.01.19.476895 — biochemistry — Posted on 2022-01-20

1700 A multivariate view of cognitive performance reveals positive correlation in the Trinidadian Guppy (Poecilia reticulata)

Prentice, P. M.; Wilson, A. J.; Thornton, A.

10.1101/2021.11.04.467320 — animal behavior and cognition — Posted on 2022-01-20

1701 Genetic control of KRAB-ZFP genes explains distal CpG-site methylation which associates with human disease phenotypes.

Bretherick, A. D.; Zeng, Y.; Walker, R. M.; Hayward, C.; Porteous, D. J.; Evans, K. L.; McIntosh, A. M.; Baillie, J. K.; Haley, C.; Ponting, C. P.

10.1101/2022.01.18.476742 — genomics — Posted on 2022-01-20

1702 Partitioning the temporal changes in abundance-based beta diversity into loss and gain components

Tatsumi, S.; Iritani, R.; Cadotte, M. W.

10.1101/2021.05.28.446095 — ecology — Posted on 2022-01-20

1703 Massively parallel genomic perturbations with multi-target CRISPR reveal new insights on Cas9 activity and DNA damage responses at endogenous sites

Zou, R. S.; Marin-Gonzalez, A.; Liu, Y.; Liu, H. B.; Shen, L.; Dveirin, R.; Luo, J. X. J.; Kalhor, R.; Ha, T.

10.1101/2022.01.18.476836 — cell biology — Posted on 2022-01-20

1704 Microtubule plus-end regulation by centriolar cap proteins

Ogunmolu, F. E.; Moradi, S.; Volkov, V. A.; van Hoorn, C.; Wu, J.; Andrea, N.; Hua, S.; Jiang, K.; Vakonakis, I. A.; Potocnjak, M.; Herzog, F.; Gigant, B.; Gudimchuk, N.; Stecker, K. E.; Dogterom, M.; Steinmetz, M. O.; Akhmanova, A.

10.1101/2021.12.29.474442 — cell biology — Posted on 2022-01-20

1705 Centriole-independent centrosome assembly in interphase mammalian cells

Chen, F.; Wu, J.; Iwanski, M. K.; Jurriens, D.; Sandron, A.; Pasolli, M.; Puma, G.; Kromhout, J. Z.; Yang, C.; Nijenhuis, W.; Kapitein, L. C.; Akhmanova, A.

10.1101/2021.08.22.457259 — cell biology — Posted on 2022-01-20

1706 Increased early sodium current provokes familial atrial fibrillation and reduces effectiveness of sodium channel block

O'Reilly, M.; Sommerfeld, L. C.; O'Shea, C.; Broadway-Stringer, S.; Andaleeb, S.; Reyat, J. S.; Kabir, S. N.; Malinova, A.; Delbue, D.; Fortmueller, L.; Gehmlich, K.; Pavlovic, D.; Skryabin, B. V.; Holmes, A. P.; Kirchhof, P.; Fabritz, L.

10.1101/2022.01.18.476646 — molecular biology — Posted on 2022-01-20

1707 HuR-dependent expression of Wisp1 is necessary for TGF????-induced cardiac myofibroblast activity

Green, L. C.; Slone, S.; Anthony, S. R.; Aube, J.; Wu, X.; Xu, L.; Kanisicak, O.; Tranter, M.

10.1101/2022.01.19.476976 — molecular biology — Posted on 2022-01-20

1708 Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress

Virtanen, L.; Holm, E.; Halme, M.; West, G.; Lindholm, F.; Gullmets, J.; Irjala, J.; Helio, T.; Padzik, A.; Meinander, A.; Eriksson, J. E.; Taimen, P.

10.1101/2022.01.19.476880 — molecular biology — Posted on 2022-01-20

1709 Merkel cell polyomavirus regulates miR183 cluster and piR62011 in Merkel cell carcinoma

Arora, R.; Dohadwala, L.; Nanavati, B. N.; Lakshmanan, V.; Mukherjee, S.

10.1101/2022.01.18.476776 — molecular biology — Posted on 2022-01-20

1710 CDC50 orthologues in Plasmodium falciparum have distinct roles in merozoite egress and trophozoite maturation

Patel, A.; Nofal, S. D.; Blackman, M.; Baker, D. A.

10.1101/2022.01.18.476868 — molecular biology — Posted on 2022-01-20

1711 Structural insights into G protein activation by D1 dopamine receptor

Teng, X.; Chen, S.; Wang, Q.; Chen, Z.; Wang, X.; Huang, N.; Zheng, S.

10.1101/2022.01.18.476830 — molecular biology — Posted on 2022-01-20

1712 Linking Dynamic DNA Secondary Structures to Genome Instability

nussenzweig, a.; Matos-Rodrigues, G.; van Wietmarschen, N.; Wu, W.; Tripathi, V.; Koussa, N.; Pavani, R.; Nathan, W.; Belinky, F.; Mohammed, A.; Napiera, M.; Usdin, K.; Ansari, A. Z.; Mirkin, S. M.

10.1101/2022.01.19.476973 — molecular biology — Posted on 2022-01-20

1713 RNF213 reshapes vascular transcriptome and epigenome; A potential role of Alternative splicing in Moyamoya pathology

Zhang, L.; Rashad, S.; Zhou, Y.; Niizuma, K.; Tominaga, T.

10.1101/2022.01.18.476838 — molecular biology — Posted on 2022-01-20

1714 Proton-pumping rhodopsins in marine diatoms

Yoshizawa, S.; Azuma, T.; Kojima, K.; Inomura, K.; Hasegawa, M.; Nishimura, Y.; Kikuchi, M.; Armin, G.; Miyashita, H.; Ifuku, K.; Yamano, T.; Marchetti, A.; Fukuzawa, H.; Sudo, Y.; Kamikawa, R.

10.1101/2022.01.18.476826 — microbiology — Posted on 2022-01-20

1715 Low diversity and instability of the sinus microbiota over time in adults with cystic fibrosis

Armbruster, C. R.; Li, K.; Kiedrowski, M. R.; Zemke, A. C.; Melvin, J. A.; Moore, J.; Atteih, S.; Manko, C. D.; Weaver, M. L.; Gaston, J. R.; Alcorn, J. F.; Morris, A.; Methe, B. A.; Lee, S. E.; Bomberger, J. M.

10.1101/2022.01.18.476814 — microbiology — Posted on 2022-01-20

1716 Identification of a biosynthetic gene cluster encoding a novel lanthanide chelator in Methylorubrum extorquens AM1

Zytnick, A. M.; Good, N. M.; Barber, C. C.; Phi, M. T.; Gutenthaler, S. M.; Zhang, W.; Daumann, L. J.; Martinez-Gomez, N. C.

10.1101/2022.01.19.476857 — microbiology — Posted on 2022-01-20

1717 Genomic diversity of Helicobacter pylori populations from different regions of the human stomach.

Wilkinson, D.; Dickins, B.; Robinson, K.; Winter, J.

10.1101/2022.01.18.476812 — microbiology — Posted on 2022-01-20

1718 SARS-CoV-2 Omicron efficiently infects human airway, but not alveolar epithelium

Lamers, M. M.; Mykytyn, A. Z.; Breugem, T. I.; Groen, N.; Knoops, K.; Schipper, D.; van Acker, R.; van den Doel, P. B.; Bestebroer, T.; Koopman, C. D.; Reusken, C.; Muraro, M. J.; GeurtsvanKessel, C. H.; van Royen, M. E.; Peters, P. J.; Zhang, J.; Haagmans, B. L.

10.1101/2022.01.19.476898 — microbiology — Posted on 2022-01-20

1719 Metagenomics revealing molecular profiling of microbial community structure and metabolic capacity in Bamucuo, Tibet

Peng, S.; Wei, C.; Sun, D.; Yuan, W.; Li, L.; Dai, C.; Chen, Z.; Zeng, X.; Wang, S.; Zhang, Y.; Jiang, S.; Wu, Z.; Liu, D.; Jiang, L.

10.1101/2022.01.18.476867 — microbiology — Posted on 2022-01-20

1720 Environmental and taxonomic drivers of bacterial extracellular vesicle production in marine ecosystems

Biller, S.; Coe, A.; Arellano, A. A.; Dooley, K.; Gong, J. S.; Yeager, E. A.; Becker, J.; Chisholm, S. W.

10.1101/2022.01.18.476865 — microbiology — Posted on 2022-01-20

1721 Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 Spike protein

Caohuy, H.; Eidelman, O.; Chen, T.; Yang, Q.; Walton, N. I.; Pollard, H. B.

10.1101/2022.01.18.476803 — microbiology — Posted on 2022-01-20

1722 Ex Vivo Validation of Six FDA-Approved Non-Receptor Tyrosine Kinase Inhibitors (NRTKIs) as Antivirals to Pandemic and Seasonal Influenza A Viruses

Meineke, R.; Stelz, S.; Busch, M.; Werlein, C.; Kuehnel, M. P.; Jonigk, D.; Rimmelzwaan, G. F.; Elbahesh, H.

10.1101/2022.01.19.476993 — microbiology — Posted on 2022-01-20

1723 Novel Internalin P homologs in Listeria

Conner, K. N.; Burke, J. T.; Hardy, J. W.; Ravi, J.

10.1101/2022.01.19.476994 — microbiology — Posted on 2022-01-20

1724 Enterococcus faecalis antagonizes Pseudomonas aeruginosa growth in polymicrobial biofilms

Tan, C. A. Z.; Lam, L. N.; Biukovic, G.; Soh, E. Y.-C.; Toh, X. W.; Lemos, J. A.; Kline, K. A.

10.1101/2022.01.18.476859 — microbiology — Posted on 2022-01-20

1725 Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

Zhang, Z.; Ju, B.; Zheng, Q.; Guo, H.; Fan, Q.; Li, T.; Song, S.; Sun, H.; Shen, S.; Zhou, X.; Cheng, L.; Xue, W.; Cui, L.; Zhou, B.; Ge, X.; Wang, H.; Wang, M.; Li, S.; Xia, N.

10.1101/2022.01.19.476892 — immunology — Posted on 2022-01-20

1726 NRP1 and furin as putative mediators of SARS-CoV-2 entry into human brain cells

Kumar, A.; Narayan, R. K.; Kumar, S.; Pareek, V.; Kumari, C.; Jha, R. K.; Prasoon, P.

10.1101/2022.01.19.476893 — neuroscience — Posted on 2022-01-20

1727 Broad-host-range mutagenesis with CRISPR-associated transposase

Rodriguez, L.; Ellington, A.; Reisch, C. R.

10.1101/2022.01.19.475551 — synthetic biology — Posted on 2022-01-20

1728 Dopamine ameliorates hyperglycemic memory-induced vascular dysfunction in diabetic retinopathy

Lee, Y.-J.; Jeon, H.-Y.; Lee, A.-J.; Kim, M.; Ha, K.-S.

10.1101/2022.01.19.476943 — biochemistry — Posted on 2022-01-20

1729 Tactical signalling by victims increases bystander consolation in bonobos

Heesen, R. M.; Austry, D. A.; Upton, Z.; Clay, Z.

10.1101/2022.01.18.476740 — animal behavior and cognition — Posted on 2022-01-20

1730 Decoding the activated stem cell phenotype of the vividly maturing neonatal pituitary

Laporte, E.; Hermans, F.; De Vriendt, S.; Vennekens, A.; Lambrechts, D.; Nys, C.; Cox, B.; Vankelecom, H.

10.1101/2022.01.18.476723 — developmental biology — Posted on 2022-01-20

1731 Unexpected growth of a classic yeast auxotroph

Van Oss, S. B.; Parikh, S. B.; Coelho, N. C.; Wacholder, A.; Belashov, I.; Michaca, M.; Xu, J.; Kang, Y. P.; McCourt, K. M.; McKee, J.; Ideker, T.; VanDemark, A. P.; DeNicola, G. M.; Carvunis, A.-R.

10.1101/2022.01.19.476918 — molecular biology — Posted on 2022-01-20

1732 Doderlin: Isolation and Characterization of a Broad-Spectrum Antimicrobial Peptide from Lactobacillus acidophilus

da Silva, B. S.; Diaz-Roa, A.; Yamane, E. S.; Hayashi, M. A. F.; Silva Junior, P. I.

10.1101/2022.01.19.476933 — microbiology — Posted on 2022-01-20

1733 Extended bacterial diversity of the urinary microbiome of reproductive-age healthy European women captured by culturomics and long-read amplicon sequencing

Ugarcina Perovic, S.; Ksiezarek, M.; Rocha, J.; Alves Cappelli, E.; Sousa, M.; Ribeiro G, T.; Grosso, F.; Peixe, L.

10.1101/2022.01.19.476882 — microbiology — Posted on 2022-01-20

1734 SARS-CoV-2 infection results in lasting and systemic perturbations post recovery

Frere, J. J.; Serafini, R. A.; Pryce, K. D.; Zazhytska, M.; Oishi, K.; Golynker, I.; Panis, M.; Zimering, J.; Horiuchi, S.; Hoagland, D. A.; Moller, R.; Ruiz, A.; Overdevest, J. B.; Kodra, A.; Canoll, P. D.; Goldman, J. E.; Borczuk, A. C.; Chandar, V.; Bram, Y.; Schwartz, R.; Lomvardas, S.; Zachariou, V.; tenOever, B.

10.1101/2022.01.18.476786 — microbiology — Posted on 2022-01-20

1735 A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants

Weinstein, J. B.; Bates, T. A.; Leier, H. C.; McBride, S. K.; Barklis, E.; Tafesse, F. G.

10.1101/2022.01.18.476801 — immunology — Posted on 2022-01-20

1736 An excitatory-inhibitory fronto-cerebellar loop resolves the Stroop effect

Okayasu, M.; Inukai, T.; Tanaka, D.; Tsumura, K.; Hosono, M.; Shintaki, R.; Takeda, M.; Nakahara, K.; Jimura, K.

10.1101/2022.01.18.476551 — neuroscience — Posted on 2022-01-20

1737 Seeing sounds: Neural mechanisms underlying auditory contributions to visual detection

Perez-Bellido, A.; Spaak, E.; de Lange, F. P.

10.1101/2022.01.19.476187 — neuroscience — Posted on 2022-01-20

1738 Probing the influence of SMA and vmPFC on the motor system with dual-site transcranial magnetic stimulation

Neige, C.; Ali Zazou, A.; Vassiliadis, P.; Lebon, F.; Brees, T.; Derosiere, G.

10.1101/2022.01.18.476729 — neuroscience — Posted on 2022-01-20

1739 Elucidating gene expression patterns across multiple biological contexts through a large-scale investigation of transcriptomic datasets

Figueiredo, R. Q.; Diaz del Ser, S.; Raschka, T.; Hofmann-Apitius, M.; Kodamullil, A. T.; Mubeen, S.; Domingo-Fernandez, D.

10.1101/2022.01.18.476735 — bioinformatics — Posted on 2022-01-20

1740 Reconstructing the spatiotemporal patterns of admixture during the European Holocene using a novel genomic dating method

Chintalapati, M.; Patterson, N.; Moorjani, P.

10.1101/2022.01.18.476710 — evolutionary biology — Posted on 2022-01-20

1741 The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys

Sasaki, K.; Cheng, K.; Seita, Y.; Moriwaki, T.; Noshiro, K.; Sakata, Y.; Hwang, Y. S.; Torigoe, T.; Saitou, M.; Tsuchiya, H.; Iwatani, C.; Hosaka, M.; Ohkouchi, T.; Watari, H.; Umazume, T.

10.1101/2022.01.19.477000 — developmental biology — Posted on 2022-01-20

1742 Hedgehog regulation of epithelial cell state and morphogenesis in the larynx

Ramachandran, J.; Zhou, W.; Bardenhagen, A. E.; Nasr, T.; Zorn, A. M.; Ji, H.; Vokes, S. A.

10.1101/2022.01.19.476887 — developmental biology — Posted on 2022-01-20

1743 SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice

Lee, K. S.; Wong, T. Y.; Russ, B. P.; Horspool, A. M.; Miller, O.; Rader, N.; Givi, J. P.; Winters, M. T.; Wong, Z. Y.; Cyphert, H. A.; Denvir, J.; Stoilov, P. G.; Barbier, M.; Roan, N.; Amin, M. S.; Martinez, I.; Bevere, J. R.; Damron, F. H.

10.1101/2022.01.18.476863 — immunology — Posted on 2022-01-19

1744 Neural hyperactivity is a core pathophysiological change induced by deletion of an autism risk gene Ash1l in the mouse brain

Gao, Y.; Aljazi, M. B.; He, J.

10.1101/2022.01.19.476965 — neuroscience — Posted on 2022-01-20

1745 High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets

Li, W.; Berlinicke, C.; Huang, Y.; Fang, W.; Chen, C.; Takaesu, F.; Chang, X.; Duan, Y.; Chang, C.; Mao, H.-Q.; Sheng, G.; Giera, S.; Dodge, J. C.; Ji, H.; Madden, S. L.; Zack, D. J.; Chamling, X.

10.1101/2022.01.18.476755 — neuroscience — Posted on 2022-01-20

1746 Changes in late frontal event-related potentials to self-produced foreign phonemes correlate with improvements in pronunciation

Railo, H.; Varjonen, A.; Lehtonen, M.; Sikka, P.

10.1101/2022.01.18.476741 — neuroscience — Posted on 2022-01-20

1747 A truncated form of the p27 CDK inhibitor translated from pre-mRNA causes cell cycle arrest at G2 phase

Kaida, D.; Satoh, T.; Ishida, K.; Yoshimoto, R.

10.1101/2022.01.12.476115 — molecular biology — Posted on 2022-01-19

1748 High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses

Sims, J. J.; Lian, S.; Wilson, J. M.

10.1101/2022.01.17.476672 — molecular biology — Posted on 2022-01-19

1749 Differences in environmental stability among SARS-CoV-2 variants of concern: Omicron has higher stability

Hirose, R.; Itoh, Y.; Ikegaya, H.; Miyazaki, H.; Watanabe, N.; Yoshida, T.; Bandou, R.; Daidoji, T.; Nakaya, T.

10.1101/2022.01.18.476607 — microbiology — Posted on 2022-01-19

1750 Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant

Rosales, R.; McGovern, B. L.; Rodriquez, M. L.; Rai, D. K.; Cardin, R. D.; Anderson, A. S.; Sordillo, E. M.; van Bakel, H.; Simon, V.; Garcia-Sastre, A.; White, K. M.

10.1101/2022.01.17.476685 — microbiology — Posted on 2022-01-19

1751 Prediction and validation of host cleavage targets of SARS-CoV-2 3C like protease

Yucel, N.; Marchiano, S.; Tchelepi, E.; McAfee, Q.; Nimmagadda, N.; Ren, A.; Shi, S.; Murry, C. E.; Arany, Z.

10.1101/2022.01.17.476677 — microbiology — Posted on 2022-01-19

1752 Lemaitre's law and the spatial distributions of the cone photoreceptors in the retinas of vertebrates

Beygi, A.

10.1101/2022.01.09.475540 — biophysics — Posted on 2022-01-19

1753 A Draft Reference Genome for Hirudo verbana, the Medicinal Leech

Paulsen, R. T.; Agany, D. D. M.; Petersen, J.; Davis, C. M.; Ehli, E. A.; Gnimpieba, E.; Burrell, B. D.

10.1101/2020.12.08.416024 — genomics — Posted on 2022-01-19

1754 Acute oral toxicity of zinc phosphide: an assessment for wild house mice in Australia

Hinds, L. A.; Henry, S.; Van de Weyer, N.; Robinson, F.; Ruscoe, W. A.; Brown, P. R.

10.1101/2021.12.09.472031 — ecology — Posted on 2022-01-19

1755 CellKb Immune: a manually curated database of hematopoietic marker gene sets from 7 species for rapid cell type identification

Patil, A.; Patil, A.

10.1101/2020.12.01.389890 — immunology — Posted on 2022-01-19

1756 Rewritable Two-Dimensional DNA-Based Data Storage with Machine Learning Reconstruction

Pan, C.; Tabatabaei, S. K.; Tabatabaei Yazdi, S. M. H.; Hernandez, A. G.; Schroeder, C. M.; Milenkovic, O.

10.1101/2021.02.22.432304 — synthetic biology — Posted on 2022-01-19

1757 Hair phenotype diversity across Indriidae lemurs

Tapanes, E.; Jacobs, R. L.; Harryman, I.; Louis, E. E.; Irwin, M. T.; Kamilar, J. M.; Bradley, B. J.

10.1101/2021.10.16.464615 — evolutionary biology — Posted on 2022-01-19

1758 Transcription Factor EB regulates phosphatidylinositol-3-phosphate levels on endomembranes and alters lysosome positioning in the bladder cancer model

Mathur, P.; De Barros Santos, C.; Lachuer, H.; Latge, B.; Radvanyi, F.; Goud, B.; Schauer, K.

10.1101/2020.07.10.196931 — cell biology — Posted on 2022-01-19

1759 Cortical waves mediate the cellular response to electric fields

Yang, Q.; Miao, Y.; Campanello, L. J.; Hourwitz, M. J.; Abubaker-Sharif, B.; Bull, A. L.; Devreotes, P. N.; Fourkas, J. T.; Losert, W.

10.1101/2021.06.08.447600 — cell biology — Posted on 2022-01-19

1760 Left Hemisphere Dominance for Bilateral Kinematic Encoding in the Human Brain

Merrick, C. M.; Dixon, T. C.; Breska, A.; Lin, J. J.; Chang, E. F.; King-Stephens, D.; Laxer, K. D.; Weber, P. B.; Carmena, J. M.; Knight, R. T.; Ivry, R. B.

10.1101/2021.05.01.442295 — neuroscience — Posted on 2022-01-19

1761 MutSigCVsyn: Identification of Thirty Synonymous Cancer Drivers

Rao, Y.; Ahmed, N.; Pritchard, J.; O'Brien, E.

10.1101/2022.01.16.476507 — bioinformatics — Posted on 2022-01-19

1762 Environment-dependence of the expression of mutational load and species' range limits

Perrier, A.; Sanchez-Castro, D.; Willi, Y.

10.1101/2021.09.15.460519 — evolutionary biology — Posted on 2022-01-19

1763 Evolving social behaviour through selection of single-cell adhesion in Dictyostelium discoideum

Adiba, S.; Forget, M.; De Monte, S.

10.1101/2021.07.15.452515 — evolutionary biology — Posted on 2022-01-19

1764 Suppression without inhibition: How retinal computation contributes to saccadic suppression

Idrees, S.; Baumann, M. P.; Korympidou, M. M.; Schubert, T.; Kling, A.; Franke, K.; Hafed, Z. M.; Franke, F.; Münch, T. A.

10.1101/2020.08.21.261198 — neuroscience — Posted on 2022-01-19

1765 The Life Span of the Great Black Wasp Sphex pensylvanicus L> (Hymenoptera: Sphecidae) and Other Observations from a Nesting Aggregation in Sioux City, Iowa, USA> 2003 -2017

Lechner, G.

10.1101/2022.01.14.476354 — zoology — Posted on 2022-01-19

1766 TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy

Hamon, P.; Gerbe de Thore, M.; Classe, M.; Signolle, N.; Liu, W.; Bawa, O.; Meziani, L.; Clemenson, C.; Milliat, F.; Deutsch, E.; Mondini, M.

10.1101/2022.01.17.476557 — cancer biology — Posted on 2022-01-19

1767 Particle flow modulates growth dynamics and nanoscale-arrested growth of transcription factor condensates in living cells

Munoz-Gil, G.; Romero-Aristizabal, C.; Mateos, N.; Campelo, F.; de LLobet-Cucalon, L. I.; Beato, M.; Lewenstein, M.; Garcia-Parajo, M.; Torreno-Pina, J. A.

10.1101/2022.01.11.475940 — biophysics — Posted on 2022-01-19

1768 ccnWheat: A Database for Comparing Co-expression Networks Analysis of Allohexaploid Wheat and Its Progenitors

Li, Z.; Hu, Y.; Ma, X.; Da, L.; She, J.; Liu, Y.; Yi, X.; Cao, Y.; Xu, W.; Jiao, Y.; SU, Z.

10.1101/2022.01.17.476536 — bioinformatics — Posted on 2022-01-19

1769 Nirmatrelvir, an orally active Mpro inhibitor, is a potent inhibitor of SARS-CoV-2 Variants of Concern

Rai, D. K.; Yurgelonis, I.; McMonagle, P.; Rothan, H. A.; Hao, L.; Gribenko, A.; Titova, E.; Kreiswirth, B.; White, K. M.; Zhu, Y.; Anderson, A. S.; Cardin, R. D.

10.1101/2022.01.17.476644 — microbiology — Posted on 2022-01-19

1770 Structural basis for Nirmatrelvir in vitro efficacy against the Omicron variant of SARS-CoV-2

Greasley, S. E.; Noell, S.; Plotnikova, O.; Ferre, R. A.; Liu, W.; Bolanos, B.; Fennell, K. F.; Nicki, J.; Craig, T.; Zhu, Y.; Stewart, A. E.; Steppan, C. M.

10.1101/2022.01.17.476556 — biochemistry — Posted on 2022-01-19

Horing, B.; Büchel, C.

10.1101/2022.01.16.476547 — neuroscience — Posted on 2022-01-19

1772 Transcriptomic and functional genetic evidence for distinct ecophysiological responses across complex life cycle stages

Freda, P. J.; Toxopeus, J.; Dowle, E. J.; Ali, Z. M.; Heter, N.; Lambert-Collier, R.; Sower, I.; Tucker, J. C.; Morgan, T. J.; Ragland, G. J.

10.1101/2022.01.16.476527 — evolutionary biology — Posted on 2022-01-19

1773 Dogma and belief: the primary lesion in age-related hearing loss is old news

McAlpine, D.; Hernandez-Perez, H.; Seeto, M.; Edwards, B.

10.1101/2022.01.14.472488 — neuroscience — Posted on 2022-01-19

1774 Impaired iron recycling from erythrocytes is an early iron-dependent hallmark of aging

Mandal, P. K.; Slusarczyk, P.; Zurawska, G.; Cybulska, M.; Krawczyk, O.; Mikula, M.; Herman, S.; Lenartowicz, M.; Serwa, R.; Pokrzywa, W.; Mleczko-Sanecka, K.

10.1101/2022.01.16.476518 — physiology — Posted on 2022-01-19

1775 UbE3-APA: A Bioinformatic Strategy to Elucidate Ubiquitin E3 Ligase Activities in Quantitative Proteomics Study

Gong, Y.; Chen, Y.

10.1101/2022.01.16.476541 — bioinformatics — Posted on 2022-01-19

1776 Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease

Guzman-Velez, E.; Diez, I.; Schoemaker, D.; Pardilla-Delgado, E.; Vila-Castelar, C.; Fox-Fuller, J. T.; Baena, A.; Sperling, R. A.; Johnson, K. A.; Lopera, F.; Sepulcre, J.; Quiroz, Y. T.

10.1101/2021.07.03.450933 — neuroscience — Posted on 2022-01-19

1777 A newly-evolved chimeric lysin motif receptor-like kinase in Medicago truncatula spp. tricycla R108 extends its Rhizobia symbiotic partnership

Luu, T.-B.; Ourth, A.; Pouzet, C.; Pauly, N.; Cullimore, J.

10.1101/2021.11.23.469708 — plant biology — Posted on 2022-01-19

1778 Role of the circadian clock "Death-Loop" in the DNA damage response underpinning cancer treatment resistance

Vainshelbaum, N. M.; Salmina, K.; Gerashchenko, B. I.; Lazovska, M.; Zayakin, P.; Cragg, M. S.; Pjanova, D.; Erenpreisa, J.

10.1101/2022.01.14.476363 — cancer biology — Posted on 2022-01-19

1779 Actin-microtubule dynamic composite forms responsive active matter with memory

Kucera, O.; Gaillard, J.; Guerin, C.; Thery, M.; Blanchoin, L.

10.1101/2022.01.10.475629 — biophysics — Posted on 2022-01-19

1780 Hierarchical autoencoder-based integration improves performance in multi-omics cancer survival models through soft modality selection

Wissel, D.; Rowson, D.; Boeva, V.

10.1101/2021.09.16.460589 — bioinformatics — Posted on 2022-01-19

1781 FLIP: Benchmark tasks in fitness landscape inference for proteins

Dallago, C.; Mou, J.; Johnston, K. E.; Wittmann, B.; Bhattacharya, N.; Goldman, S. L.; Madani, A.; Yang, K. K.

10.1101/2021.11.09.467890 — bioengineering — Posted on 2022-01-19

1782 CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7

Tan, Y. Z.; Abbas, Y. M.; Wu, J. Z.; Wu, D.; Hesketh, G. G.; Bueler, S. A.; Gingras, A.-C.; Robinson, C. V.; Grinstein, S.; Rubinstein, J. L.

10.1101/2021.11.03.466369 — biochemistry — Posted on 2022-01-19

1783 Rapid and parallel adaptive mutations in spike S1 drive clade success in SARS-CoV-2

Kistler, K.; Huddleston, J.; Bedford, T.

10.1101/2021.09.11.459844 — evolutionary biology — Posted on 2022-01-19

1784 Comparison of Three Individual Identification Algorithms for Sperm Whales (Physeter macrocephalus) after Automated Detection

Holmberg, J.; Gero, S.; Blount, A.; Parham, J.; Levenson, j.; Gordon, J.

10.1101/2021.12.22.473895 — ecology — Posted on 2022-01-19

1785 Competent immune responses to SARS-CoV-2 variants in older adults following mRNA vaccination

Jergovic, M.; Uhrlaub, J. L.; Watanabe, M.; Bradshaw, C. M.; White, L. M.; LaFleur, B. J.; Edwards, T.; Sprissler, R.; Worobey, M.; Bhattacharya, D.; Nikolich-Zugich, J.

10.1101/2021.07.22.453287 — immunology — Posted on 2022-01-19

1786 Flexible and efficient simulation-based inference for models of decision-making

Boelts, J.; Lueckmann, J.-M.; Gao, R.; Macke, J. H.

10.1101/2021.12.22.473472 — neuroscience — Posted on 2022-01-19

1787 Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

Gargareta, V.-I.; Reuschenbach, J.; Siems, S. B.; Sun, T.; Piepkorn, L.; Mangana, C.; Späte, E.; Goebbels, S.; Huitinga, I.; Möbius, W.; Nave, K.-A.; Jahn, O.; Werner, H. B.

10.1101/2022.01.17.476643 — neuroscience — Posted on 2022-01-19

1788 NestedBD: Bayesian Inference of Phylogenetic Trees From Single-Cell DNA Copy Number Profile Data Under a Birth-Death Model

Liu, Y.; Edrisi, M.; Ogilvie, H.; Nakhleh, L.

10.1101/2022.01.16.476510 — cancer biology — Posted on 2022-01-19

1789 Viability, task switching, and fall avoidance of the simplest dynamic walker

Patil, N. S.; Dingwell, J. B.; Cusumano, J. P.

10.1101/2022.01.16.476517 — bioengineering — Posted on 2022-01-19

1790 A protocol for locating and counting transgenic sequences from laboratory animals using a map-then-capture (MapCap) sequencing workflow: procedure and application of results.

Dicke, S. S.; Rubinstein, D.; Speers, J.; Berres, M.; Pavelec, D.; Schueler, K.; Stapleton, D.; Simonett, S.; Keller, M.; Attie, A.; Zanni, M.

10.1101/2022.01.13.476149 — genetics — Posted on 2022-01-19

1791 CaPTrends: A global database of Carnivoran Population Trends

Johnson, T. F.; Cruz, P.; Isaac, N. J. B.; Paviolo, A.; Gonzalez-Suarez, M.

10.1101/2022.01.13.476193 — ecology — Posted on 2022-01-19

1792 Re-use of labware reduces CO2 equivalent footprint and running costs in laboratories

Farley, M.; Nicolet, B. P.

10.1101/2022.01.14.476337 — cell biology — Posted on 2022-01-19

1793 Computed tomographic analysis of the dental system of three Jurassic ceratopsians: implications for the evolution of the tooth replacement pattern and diet in early-diverging ceratopsians

Hu, J.; Forster, C. A.; Xu, X.; Zhao, Q.; He, Y.; Han, F.

10.1101/2022.01.16.476516 — paleontology — Posted on 2022-01-19

1794 Self-healing codes: how stable neural populations can track continually reconfiguring neural representations

Rule, M. E.; O'Leary, T.

10.1101/2021.03.08.433413 — neuroscience — Posted on 2022-01-19

1795 Proteolytic cleavage of the extracellular domain affects signaling of parathyroid hormone receptor 1

Klenk, C.; Hommers, L.; Lohse, M. J.

10.1101/2021.12.16.472984 — pharmacology and toxicology — Posted on 2022-01-19

1796 NIMAA: an R/CRAN package to accomplish NomInal data Mining AnAlysis

Jafari, M.; Chen, C.; Mirzaie, M.; Tang, J.

10.1101/2022.01.13.475835 — bioinformatics — Posted on 2022-01-19

1797 Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologies

Murtaza, N.; Cheng, A. A.; Brown, C. O.; Meka, D. P.; Hong, S.; Uy, J. A.; El-Hajjar, J.; Pipko, N.; Unda, B. K.; Schwanke, B.; Xing, S.; Thiruvahindrapuram, B.; Worrawat, E.; Trost, B.; Deneault, E.; Calderon de Anda, F.; Doble, B. W.; Ellis, J.; Anagnostou, E.; Bader, G. D.; Scherer, S. W.; Lu, Y.; Singh, K. K.

10.1101/2022.01.17.476220 — neuroscience — Posted on 2022-01-19

1798 Embedded 3D printing in self-healing annealable composites for precise patterning of functionally mature human neural constructs

Kajtez, J.; Wesseler, M. F.; Birtele, M.; Khorasgani, F. R.; Ottosson, D. R.; Heiskanen, A.; Kamperman, T.; Leijten, J.; Martinez-Serrano, A.; Larsen, N. B.; Angelini, T. E.; Parmar, M.; Lind, J. U.; Emneus, J.

10.1101/2021.08.04.455135 — bioengineering — Posted on 2022-01-19

1799 Effect of habitual reading direction on saccadic eye movements

Lyu, A.; Abel, L.; Cheong, A. M. Y.

10.1101/2022.01.18.476817 — neuroscience — Posted on 2022-01-18

1800 Rethinking Statistical Learning as a Dynamic Stochastic Process, from The Motor Systems Perspective

Vaskevich, A.; Torres, E. B.

10.1101/2022.01.18.476831 — neuroscience — Posted on 2022-01-19

1801 Algorithms for Estimating Time-Locked Neural Response Components in Cortical Processing of Continuous Speech

Kulasingham, J. P.; Simon, J. Z.

10.1101/2022.01.18.476815 — neuroscience — Posted on 2022-01-19

1802 Prenatal opioid exposure inhibits microglial sculpting of the dopamine system during adolescence

Smith, C. J.; Lintz, T.; Clark, M. J.; Malacon, K. E.; Constantino, N.; Abiad, A.; Alonso-Caraballo, Y.; Kim, V. J.; Jo, Y. C.; Bilbo, S. D.; Chartoff, E. H.

10.1101/2021.11.28.468091 — neuroscience — Posted on 2022-01-18

1803 Identification of differential hypothalamic DNA methylation and gene expression associated with sexual partner preferences in rams

Bhattacharya, S.; Amodei, R.; Vilain, E.; Roselli, C. E.

10.1101/2022.01.18.476818 — neuroscience — Posted on 2022-01-18

1804 Plasticity of body axis polarity in Hydra regeneration under constraints

Livshits, A.; Garion, L.; Maroudas-Sacks, Y.; Shani-Zerbib, L.; Keren, K.; Braun, E.

10.1101/2021.02.04.429818 — biophysics — Posted on 2022-01-18

1805 DEPP: Deep Learning Enables Extending Species Trees using Single Genes

Jiang, Y.; Balaban, M.; Zhu, Q.; Mirarab, S.

10.1101/2021.01.22.427808 — bioinformatics — Posted on 2022-01-18

1806 MaveDB v2: a curated community database with over three million variant effects from multiplexed functional assays

Rubin, A. F.; Min, J. K.; Rollins, N. J.; Da, E. Y.; Esposito, D.; Harrington, M.; Stone, J.; Bianchi, A. H.; Dias, M.; Frazer, J.; Fu, Y.; Gallaher, M.; Li, I.; Moscatelli, O.; Ong, J. Y.; Rollins, J. E.; Wakefield, M. J.; Ye, S.; Tam, A.; McEwen, A. E.; Starita, L. M.; Bryant, V. L.; Marks, D. S.; Fowler, D. M.

10.1101/2021.11.29.470445 — genomics — Posted on 2022-01-18

1807 Genome sequence data reveal at least two distinct incursions of the tropical race 4 (TR4) variant of Fusarium wilt into South America

Reyes-Herrera, P. H.; Torres-Bedoya, E.; Lopez-Alvarez, D.; Burbano-David, D.; Carmona, S. L.; Bebber, D. P.; Studholme, D. J.; Betancourt, M.; Soto-Suarez, M.

10.1101/2022.01.17.476647 — genomics — Posted on 2022-01-18

1808 Unearthing modes of climatic adaptation in underground storage organs across Liliales

Tribble, C. M.; May, M. R.; Jackson-Gain, A.; Zenil-Ferguson, R.; Specht, C. D.; Rothfels, C. J.

10.1101/2021.09.03.458928 — evolutionary biology — Posted on 2022-01-18

1809 Gene-rich X chromosomes implicate intragenomic conflict in the evolution of bizarre genetic systems

Anderson, N.; Jaron, K. S.; Hodson, C. N.; Couger, M. B.; Sevcik, J.; Weinstein, B.; Pirro, S.; Ross, L.; Roy, S. W.

10.1101/2020.10.04.325340 — evolutionary biology — Posted on 2022-01-18

1810 Live-cell fluorescence lifetime multiplexing using synthetic fluorescent probes

Frei, M. S.; Koch, B.; Hiblot, J.; Johnsson, K.

10.1101/2022.01.15.476486 — cell biology — Posted on 2022-01-18

1811 Mechanisms of A-type lamin targeting to nuclear ruptures are disrupted in LMNA- and BANF1-associated progerias

Sears, R. M.; Roux, K. J.

10.1101/2022.01.14.476371 — cell biology — Posted on 2022-01-18

1812 Systems-wide analysis of the GATC-binding nucleoid-associated protein Gbn and its impact on Streptomyces development

Du, C.; Willemse, J.; Carrion, V. J.; Erkelens, A. M.; Dame, R. T.; van Wezel, G. P.

10.1101/2021.02.06.430045 — molecular biology — Posted on 2022-01-18

1813 A PCNA-K164R mutation impinges on origin activation and mitotic DNA synthesis

Leung, W.; Baxley, R. M.; Thakar, T.; Chang, Y.-C.; Rogers, C. B.; Wang, L.; Durrett, W.; Tella, A.; Moldovan, G.-L.; Shima, N.; Bielinsky, A. K.

10.1101/2020.06.25.172361 — molecular biology — Posted on 2022-01-18

1814 Neuronal primary cilia regulate pyramidal cell positioning to the deep and superficial sublayers in the hippocampal CA1

Yang, J.; Qiu, L.; Chen, X.

10.1101/2021.12.21.473383 — neuroscience — Posted on 2022-01-18

1815 Cycles of transcription and local translation support molecular long-term memory in the hippocampus

Das, S.; Lituma, P. J.; Castillo, P. E.; Singer, R. H.

10.1101/2021.10.29.466479 — neuroscience — Posted on 2022-01-18

1816 A Multimodal Approach to Investigate the Neural Mechanisms of Real World Social Vision

Alreja, A.; Ward, M. J.; Ma, Q.; Russ, B.; Bickel, S.; Van Wouwe, N.; Gonzalez-Martinez, J. A.; Neimat, J.; Bagic, A.; Abel, T. J.; Parker, L. S.; Richardson, M.; Schroeder, C. E.; Morency, L.-P.; Ghuman, A. S.

10.1101/2021.12.26.474173 — neuroscience — Posted on 2022-01-18

1817 In Vivo Multi-Day Calcium Imaging of CA1 Hippocampus in Freely Moving Rats Reveals a High Preponderance of Place Cells with Consistent Place Fields

Wirtshafter, H. S.; Disterhoft, J. F.

10.1101/2021.08.17.456533 — neuroscience — Posted on 2022-01-18

1818 Glutathione regulates transcriptional activation of iron transporters via S-nitrosylation of bHLH factors to modulate subcellular iron homeostasis

Shee, R.; Ghosh, S.; Khan, P.; Sahid, S.; Roy, C.; Shee, D.; Paul, S.; Datta, R.

10.1101/2021.05.09.443283 — plant biology — Posted on 2022-01-18

1819 Can foot placement during gait be trained? Adaptations in stability control when ankle moments are constrained

Hoogstad, L. A.; van Leeuwen, A. M.; van Dieen, J. H.; Bruijn, S. M.

10.1101/2021.08.13.456273 — biophysics — Posted on 2022-01-18

1820 Prediction of evolutionary constraint by genomic annotations improves prioritization of causal variants in maize

Ramstein, G. P.; Buckler, E. S.

10.1101/2021.09.03.458856 — genomics — Posted on 2022-01-18

1821 Maintenance of copy number variation at the human salivary agglutinin gene (DMBT1) by balancing selection driven by host-microbe interactions

Alharbi, A.; Sheng, N.; Nicol, K.; Strömberg, N.; Hollox, E.

10.1101/2021.10.29.466477 — genetics — Posted on 2022-01-18

1822 Evolution of anticipatory effects mediated by epigenetic changes

Kronholm, I.

10.1101/2020.09.30.321091 — evolutionary biology — Posted on 2022-01-18

1823 Are experiment sample sizes adequate to detect biologically important interactions between multiple stressors?

Burgess, B. J.; Jackson, M. C.; Murrell, D. J.

10.1101/2021.07.21.453207 — ecology — Posted on 2022-01-18

1824 Suicidal chemotaxis in bacteria

Oliveira, N. M.; Wheeler, J. H. R.; Deroy, C.; Booth, S. C.; Walsh, E. J.; Durham, W. M.; Foster, K. R.

10.1101/2021.12.21.473623 — microbiology — Posted on 2022-01-18

1825 A deep learning pipeline for segmentation of Proteus mirabilis colony patterns

Doshi, A.; Shaw, M.; Tonea, R.; Minyety, R.; Moon, S.; Laine, A.; Guo, J.; Danino, T.

10.1101/2022.01.17.475672 — microbiology — Posted on 2022-01-18

1826 Divergent effects of absolute evidence magnitude on decision accuracy and confidence in perceptual judgements

Ko, Y. H.; Feuerriegel, D. C.; Turner, W.; Overhoff, H.; Niessen, E.; Stahl, J.; Hester, R.; Fink, G. R.; Weiss, P. H.; Bode, S.

10.1101/2021.07.04.451079 — neuroscience — Posted on 2022-01-18

1827 Impact of pre-breeding feeding practices on rabbit mammary gland development at mid-pregnancy.

Hue-Beauvais, C.; Bebin, K.; Robert, R.; Gardan-Salmon, D.; Maupin, M.; Brun, N.; Aujean, E.; simon, s.; Charlier, M.; Le Provost, F.

10.1101/2022.01.17.476562 — physiology — Posted on 2022-01-18

1828 Exposure to 1800 MHz LTE electromagnetic fields under proinflammatory conditions decreases the response strength and increases the acoustic threshold of auditory cortical neurons.

SOUFFI, S.; LAMETH, J.; GAUCHER, Q.; ARNAUD-CORMOS, D.; LEVEQUE, P.; EDELINE, J.-M.; MALLAT, M.

10.1101/2022.01.13.476168 — neuroscience — Posted on 2022-01-18

1829 Metabolic competition between lipid metabolism and histone methylation regulates sexual differentiation in human malaria parasites.

Harris, C. T.; Tong, X.; Campelo Morillo, R.; Vanheer, L. N.; Marreiros, I. M.; Nahiyaan, N.; Zuzarte-Luis, V. A.; Deitsch, K. W.; Mota, M. M.; Rhee, K. Y.; Kafsack, B. F. C.

10.1101/2022.01.18.476397 — systems biology — Posted on 2022-01-18

1830 Video based phenotyping platform for the laboratory mouse

Beane, G.; Geuther, B. Q.; Sproule, T. J.; Trapszo, J.; Hession, L.; Kohar, V.; Kumar, V.

10.1101/2022.01.13.476229 — animal behavior and cognition — Posted on 2022-01-18

1831 In vitro demonstration of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome

Forster, S. C.; Liu, J.; Kumar, N.; Gulliver, E.; Gould, J. A.; Escobar-Zepeda, A.; Mkandawire, T. T.; Pike, L. J.; Shao, Y.; Stares, M. D.; Browne, H. P.; Neville, B. A.; Lawley, T. D.

10.1101/2022.01.18.476738 — genomics — Posted on 2022-01-18

1832 Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

Martin, D. P.; Lytras, S.; Lucaci, A. G.; Maier, W.; Gruning, B.; Shank, S. D.; Weaver, S.; MacLean, O. S.; Orton, R. J.; Lemey, P.; Boni, M. F.; Tegally, H.; Harkins, G. W.; Scheepers, C.; Bhiman, J. N.; Everatt, J.; Amoako, D. G.; San, J. E.; Giandhari, J.; Sigal, A.; NGS-SA, ; Williamson, C.; Hsiao, N.-y.; von Gottberg, A.; De Klerk, A.; Shafer, R. W.; Robertson, D. L.; Wilkinson, R. J.; Sewell, B. T.; Lessells, R.; Nekrutenko, A.; Greaney, A. J.; Starr, T. N.; Bloom, J. D.; Murrell, B.; Wilkinson, E.; Gupta, R. K.; de Oliveira, T.; Kosakovsky Pond, S. L.

10.1101/2022.01.14.476382 — evolutionary biology — Posted on 2022-01-18

1833 Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle-specific signatures in mouse embryos

Tekko, T.; Novoa, A.; Mallo, M.

10.1101/2022.01.18.476730 — developmental biology — Posted on 2022-01-18

1834 Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells

Rottier, R. J.; Eenjes, E.; Boerema-de Munck, A.; Buscop-van Kempen, M.; Tibboel, D.

10.1101/2022.01.18.476762 — developmental biology — Posted on 2022-01-18

1835 A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing

Dai, S.; Tang, X.; Li, L.; Ishidate, T.; Ozturk, A. R.; Chen, H.; Yan, Y.-H.; Dong, M.-Q.; Shen, E.-Z.; Mello, C. C.

10.1101/2022.01.18.476504 — molecular biology — Posted on 2022-01-18

1836 Elevation of Clavibacter michiganensis subsp. californiensis to species level as Clavibacter californiensis sp. nov., merging and re-classification of Clavibacter michiganensis subsp. chilensis and Clavibacter michiganensis subsp. phaseoli as Clavibacter chilensis sp. nov. based on complete genome in-silico analyses

Arizala, D.; Dobhal, S.; Alvarez, A. M.; Arif, M.

10.1101/2022.01.17.476658 — microbiology — Posted on 2022-01-18

1837 Genomic surveillance of Bacillus cereus sensu lato strains isolated from meat and poultry products in South Africa enables inter- and intra-national surveillance and source tracking

Carroll, L. M.; Pierneef, R.; Mathole, A.; Atanda, A.; Matle, I.

10.1101/2022.01.18.476746 — microbiology — Posted on 2022-01-18

1838 Development of an HIV reporter virus that identifies latently infected CD4+ T cells

Kim, E. H.; Manganaro, L.; Schotsaert, M.; Brown, B.; Mulder, L.; Simon, V.

10.1101/2022.01.17.476679 — microbiology — Posted on 2022-01-18

1839 Polyfunctional IL-17A+ MAIT cells are expanded in the peripheral blood of patients with HLA-B27+ axial spondyloarthritis

Lefton, M.; Sharma, N.; Patel, A. R.; Sparks, J. A.; Ermann, J.

10.1101/2022.01.17.475829 — immunology — Posted on 2022-01-18

1840 Arresting microbiome development limits immune system maturation and resistance to infection.

Lubin, J.-B.; Green, J.; Maddux, S.; Denu, L.; Duranova, T.; Lanza, M.; Wynosky-Dolfi, M.; Brodsky, I. E.; Planet, P. J.; Silverman, M. A.

10.1101/2022.01.17.476513 — immunology — Posted on 2022-01-18

1841 Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes

Park, C.-S.; Guan, J.; Rhee, P.; Gonzalez, F.; Coscoy, L.; Robey, E. A.; Shastri, N.; Sadegh-Nasseri, S.

10.1101/2022.01.18.476719 — immunology — Posted on 2022-01-18

1842 Systematic histone H4 replacement in Arabidopsis thaliana reveals a role for H4R17 in regulating flowering time

Corcoran, E. T.; LeBlanc, C.; Arias Tsang, M.; Sarkiss, A.; Hu, Y.; Pedmale, U. V.; Jacob, Y.

10.1101/2022.01.17.476649 — plant biology — Posted on 2022-01-18

1843 SUMO/deSUMOylation of the BRI1 brassinosteroid receptor modulates plant growth responses to temperature

Naranjo-Arcos, M.; Srivastava, M.; Bhardwarj, M.; Sadanandom, A.; Vert, G.

10.1101/2022.01.17.476605 — plant biology — Posted on 2022-01-18

1844 Single cell profiling of γδ hepatosplenic T-cell lymphoma unravels tumor cell heterogeneity associated with disease progression

Song, W.; Zhang, H.; Yang, F.; Nakahira, K.; Wang, C.; Shi, K.; Zhang, R.

10.1101/2022.01.17.476575 — cancer biology — Posted on 2022-01-18

1845 Activation of the Integrated Stress Response overcomes multidrug resistance in FBXW7-deficient cells

Sanchez-Burgos, L.; Navarro-Gonzalez, B.; Garcia-Martin, S.; Tejero, H.; Anton, M. E.; Al-Shahrour, F.; Fernandez-Capetillo, O.

10.1101/2022.01.17.476566 — cancer biology — Posted on 2022-01-18

1846 Dual Targeting of FLT3 and LSD1 Disrupts the MYC Super-Enhancer Complex in Acute Myeloid Leukemia

Yashar, W. M.; Smith, B. M.; Coleman, D. J.; VanCampen, J.; Kong, G.; Macaraeg, J.; Estabrook, J.; Demir, E.; Long, N.; Bottomly, D.; McWeeney, S. K.; Tyner, J. W.; Druker, B. J.; Maxson, J. E.; Braun, T. P.

10.1101/2022.01.17.476469 — cancer biology — Posted on 2022-01-18

1847 AXL-TBK1 driven nuclear AKT3 promotes metastasis

Arner, E. N.; Westcott, J. M.; Hinz, S.; Tiron, C. E.; Blo, M.; Mai, A.; Virtakoivu, R.; Phinney, N. Z.; Nord, S.; Aguilera, K. Y.; Rizvi, A.; Toombs, J. E.; Reese, T.; Fey, V.; Micklem, D.; Gausdal, G.; Ivaska, J.; Lorens, J.; Brekken, R. A.

10.1101/2022.01.17.476632 — cancer biology — Posted on 2022-01-18

1848 Capturing non-local through-bond effects in molecular mechanics force fields: II. Using fractional bond orders to fit torsion parameters

Stern, C. D.; Maat, J.; Dotson, D. L.; Bayly, C. I.; Smith, D. G. A.; Mobley, D. L.; Chodera, J. D.

10.1101/2022.01.17.476653 — biophysics — Posted on 2022-01-18

1849 Ultra high diversity factorizable libraries for efficient therapeutic discovery

Dai, Z.; Saksena, S. D.; Horny, G.; Banholzer, C.; Ewert, S.; Gifford, D. K.

10.1101/2022.01.17.476670 — bioengineering — Posted on 2022-01-18

1850 De-tensioning of collagen fibers optimizes endometrial receptivity and improves the rate of embryo implantation

Zehorai, E.; Gross, T.; Shimshoni, E.; Hadas, R.; Adir, I.; Golani, O.; Molodij, G.; Eitan, R.; Kadler, K.; Neeman, M.; Dakel, N.; Solomonov, I.; Sagi, I.

10.1101/2022.01.18.476712 — biochemistry — Posted on 2022-01-18

1851 MicroRNA Detection in Biological Media Using a Split Aptamer Platform

Wang, L.; Hast, K.; Aggarwal, T.; Baci, M.; Hong, J.; Izgu, E. C.

10.1101/2022.01.17.476684 — biochemistry — Posted on 2022-01-18

1852 How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein

Kozlov, A. G.; Cheng, X.; Zhang, H.; Shinn, M. K.; Weiland, E.; Nguyen, B.; Shkel, I. A.; Zytkiewicz, E.; Finkelstein, I. J.; Record, M. T.; Lohman, T. M.

10.1101/2022.01.17.476650 — biochemistry — Posted on 2022-01-18

1853 Super-silencers regulated by chromatin interactions control apoptotic genes

Zhang, Y.; Chen, K.; Cai, Y.; Nambu, A.; See, Y. X.; Fu, C.; Raju, A.; Lakshmanan, M.; Osato, M.; Tergaonkar, V.; Fullwood, M.

10.1101/2022.01.17.476559 — genomics — Posted on 2022-01-18

1854 Parallel evolution of amphioxus and vertebrate small-scale gene duplications

Braso-Vives, M.; Marletaz, F.; Echchiki, A.; Mantica, F.; Acemel, R. D.; Gomez-Skarmeta, J. L.; Targa, L. L.; Pontarotti, P.; Tena, J. J.; Maeso, I.; Escriva, H.; Irimia, M.; Robinson-Rechavi, M.

10.1101/2022.01.18.476203 — evolutionary biology — Posted on 2022-01-18

1855 xia2.multiplex: a multi-crystal data analysis pipeline

Gildea, R. J.; Beilsten-Edmands, J.; Axford, D.; Horrell, S.; Aller, P.; Sandy, J.; Sanchez-Weatherby, J.; Owen, C. D.; Lukacik, P.; Strain-Damerell, C. J.; Owen, R. L.; Walsh, M. A.; Winter, G.

10.1101/2022.01.17.476589 — molecular biology — Posted on 2022-01-18

1856 A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response in human cells

Lemay, J.-F.; St-Hilaire, E.; Gezzar-Dandashi, S.; McQuaid, M.; Ronato, D. A.; Gao, Y.; Belanger, F.; Sawchyn, C.; Kimenyi-Ishimwe, A. B.; Mallette, F. A.; Masson, J.-Y.; Drobetsky, E. A.; Wurtele, H.

10.1101/2022.01.17.476707 — molecular biology — Posted on 2022-01-18

1857 Mucociliary Transport Deficiency and Disease Progression in Syrian Hamsters with SARS-CoV-2 Infection

Li, Q.; Vijaykumar, K.; Phillips, S.; Hussain, S. S.; Huynh, V. N.; Fernandez-Petty, C. M.; Peabody Lever, J. E.; Foote, J. B.; Ren, J.; Campos-Gomez, J.; Daya, F. A.; Hubbs, N. W.; Kim, H.; Onuoha, E.; Boitet, E. R.; Fu, L.; Leung, H. M.; Yu, L.; Detchemendy, T. W.; Schaefers, L. T.; Tipper, J. L.; Edwards, L. J.; Leal, S. M.; Harrod, K. S.; Tearney, G. J.; Rowe, S. M.

10.1101/2022.01.16.476016 — microbiology — Posted on 2022-01-18

1858 Trypanosoma brucei: A novel system for metacyclogenesis and complete cyclical development in vitro

Nickel, B.; Fasler, M.; Brun, R.; Kaminsky, R.; Roditi, I.; Jenni, L.

10.1101/2022.01.18.476722 — microbiology — Posted on 2022-01-18

1859 Evidence of increased Cathepsin B/L and decreased TMPRSS2 usage for cell entry by the SARS-CoV-2 Omicron variant

Padmanabhan, P.; Dixit, N. M.

10.1101/2022.01.13.476267 — microbiology — Posted on 2022-01-18

1860 Infection strategy and biogeography distinguish cosmopolitan groups of marine jumbo bacteriophages

Weinheimer, A. R.; Aylward, F. O.

10.1101/2022.01.18.476781 — microbiology — Posted on 2022-01-18

1861 ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of liver cells

Yang, X.; Zhu, Y.; Zhao, X.; Liu, J.; Xun, J.; Yuan, S.; Chen, J.; Pan, H.; Yang, J.; Wang, J.; Liang, Z.; Shen, X.; Liang, Y.; Lin, Q.; Liang, H.; Li, M.; Lu, H.; Zhu, H.

10.1101/2022.01.15.476426 — microbiology — Posted on 2022-01-18

1862 Obesity associated with attenuated tissue immune cell responses in COVID-19

Guo, S. A.; Bowyer, G. S.; Ferdinand, J. R.; Maes, M.; Tuong, Z. K.; Gilman, E.; Liao, M.; Lindeboom, R. G. H.; Yoshida, M.; Worlock, K.; Gopee, H.; Stephenson, E.; Lyons, P. A.; Smith, K. G. C.; Haniffa, M.; Meyer, K. B.; Nikolic, M. Z.; Zhang, Z.; Wunderink, R. G.; Misharin, A. V.; Dougan, G.; Navapurkar, V.; Teichmann, S. A.; Morris, A. C.; Clatworthy, M. R.

10.1101/2022.01.14.475727 — immunology — Posted on 2022-01-18

1863 Chronic hyperglycemia drives alterations in macrophage effector function in pulmonary tuberculosis

Panda, S.; Seelan, D. M.; Faisal, S.; Luthra, K.; Palanichamy, J. K.; Mohan, A.; Vikram, N. K.; Gupta, N. K.; Ramakrishnan, L.; Singh, A.

10.1101/2022.01.18.476721 — immunology — Posted on 2022-01-18

1864 Central tolerance is impaired in the middle-aged thymic environment

Lancaster, J. N.; Keatinge-Clay, D. L.; Srinivasan, J.; Li, Y.; Selden, H. J.; Nam, S.; Richie, E. R.; Ehrlich, L. I. R.

10.1101/2022.01.17.476690 — immunology — Posted on 2022-01-18

1865 Mapping the developing human immune system across organs

Suo, C.; Dann, E.; Goh, I.; Jardine, L.; Kleshchevnikov, V.; Park, J.-E.; Botting, R. A.; Stephenson, E.; Engelbert, J.; Tuong, Z. K.; Polanski, K.; Yayon, N.; Xu, C.; Suchanek, O.; Elmentaite, R.; Dominguez Conde, C.; He, P.; Pritchard, S.; Miah, M.; Moldovan, C.; Steemers, A. S.; Prete, M.; Marioni, J. C.; Clatworthy, M. R.; Haniffa, M.; Teichmann, S. A.

10.1101/2022.01.17.476665 — immunology — Posted on 2022-01-18

1866 Genome-wide identification of preferentially located motifs in gene-proximal regions provides new insights into cis-regulatory sequences in plants

Roziere, J.; Guichard, C.; Brunaud, V.; Martin, M.-L.; Coursol, S.

10.1101/2022.01.17.476590 — genomics — Posted on 2022-01-18

1867 Differential sensory and immune gene evolution in sea turtles with contrasting demographic and life histories

Bentley, B. P.; Carrasco-Valenzuela, T.; Ramos, E. K. S.; Pawar, H.; Arantes, L. S.; Alexander, A.; Banerjee, S. M.; Masterson, P.; Kuhlwilm, M.; Pippel, M.; Mountcastle, J.; Haase, B.; Silva, M. U.; Formenti, G.; Howe, K.; Chow, W.; Tracey, A.; Sims, Y.; Pelan, S.; Wood, J.; Perrault, J. R.; Stewart, K.; Benson, S.; Levy, Y.; Todd, E. V.; Shaffer, H. B.; Scott, P.; Henen, B. T.; Murphy, R. W.; Mohr, D. W.; Scott, A. F.; Gemmell, N.; Suh, A.; Winkler, S.; Thibaud-Nissen, F.; Nery, M. F.; Marques-Bonet, T.; Antunes, A.; Tikochinski, Y.; Dutton, P. H.; Fedrigo, O.; Myers, E. W.; Jarvis, E.; Mazz

10.1101/2022.01.10.475373 — genomics — Posted on 2022-01-18

1868 Supporting per-locus substitution rates improves the accuracy of species networks and avoids spurious reticulations

Cao, Z.; Ogilvie, H.; Nakhleh, L.

10.1101/2022.01.16.476511 — evolutionary biology — Posted on 2022-01-18

1869 Bacterial lipopolysaccharide induces settlement and metamorphosis in a marine larva

Freckelton, M. L.; Nedved, B. T.; Cai, Y.-S.; Cao, S.; Turano, H.; Alegado, R. A.; Hadfield, M. G.

10.1101/851519 — ecology — Posted on 2022-01-18

1870 Culture and genomic analysis of Symbiopectobacterium purcellii, gen.nov. sp. nov., isolated from the leafhopper Empoasca decipiens

Nadal-Jimenez, P.; Siozios, S.; Halliday, N.; Camara, M.; Hurst, G. D. D.

10.1101/2022.01.15.476461 — microbiology — Posted on 2022-01-18

1871 CRISPR screens for host factors critical for infection by SARS-CoV-2 variants of concern identify GATA6 as a central modulator of ACE2.

Israeli, M.; Finkel, Y.; Yahalom-Rone, Y.; Paran, N.; Chitlaru, T.; Israeli, O.; Cohen-Gihon, I.; Aftalion, M.; Falach, R.; Elia, U.; Nemet, I.; Kliker, L.; Mandelboim, M.; Beth-Din, A.; Israely, T.; Cohen, O.; Stern-Ginossar, N.; Bercovich-Kinori, A.

10.1101/2021.07.19.452809 — microbiology — Posted on 2022-01-18

1872 Human foraging for primary rewards is guided by fronto-hippocampal dynamics of future anticipation

Shintaki, R.; Tanaka, D.; Suzuki, S.; Yoshimoto, T.; Sadato, N.; Chikazoe, J.; Jimura, K.

10.1101/2021.11.16.468916 — neuroscience — Posted on 2022-01-18

1873 Hepatocyte serine palmitoyl transferase 2 deficiency promotes liver C16:0-ceramide accumulation through sphingomyelin hydrolysis and leads to liver damage and dysfunction in mice

Lallement, J.; Raho, I.; Merlen, G.; Rainteau, D.; Croyal, M.; Schiffano, M.; Kassis, N.; Doignon, I.; Soty, M.; Krempf, M.; Amouyal, C.; Le Stunff, H.; Magnan, C.; Tordjmann, T.; Cruciani-Guglielmacci, C.

10.1101/2021.09.16.460588 — physiology — Posted on 2022-01-18

1874 YAP restricts renal inflammation and mitigates kidney damage in nephronothisis related kidney disease.

Ferri, G.; Goffette, V.; Poree, E.; Braeg, S.; Carvalho, S.; Quatredeniers, M.; Kuehn, E. W.; Saunier, S.; Viau, A.

10.1101/2022.01.17.475784 — pathology — Posted on 2022-01-18

1875 Role of Water-bridged Interactions in Metal Ion Coupled Protein Allostery

Guan, X.; Tan, C.; Li, W.; Wang, W.; Thirumalai, D.

10.1101/639468 — biochemistry — Posted on 2022-01-18

1876 Short-term instantaneous prophylaxis and efficient treatment against SARS-CoV-2 in hACE2 mice conferred by an intranasal nanobody (Nb22)

Wu, X.; Wang, Y.; Cheng, L.; Ni, F.; Zhu, L.; Ma, S.; Huang, B.; Ji, M.; Hu, H.; Li, Y.; Xu, S.; Shi, H.; Liu, L.; Nawaz, W.; Hu, Q.; Ye, S.; Liu, Y.; Wu, Z.

10.1101/2021.09.06.459055 — microbiology — Posted on 2022-01-18

1877 Evolutionary conservation of A/T-ending codons reflects co-regulation of expression and complex formation.

Benisty, H.; Hernandez-Alias, X.; Weber, M.; Anglada-Girotto, M.; Mantica, F.; Radusky, L.; Senger, G.; Weghorn, D.; Irimia, M.; Schaefer, M. H.; Serrano, L.

10.1101/2022.01.17.475622 — evolutionary biology — Posted on 2022-01-18

1878 Bayesian stroke modeling details sex biases in the white matter substrates of aphasia

Kernbach, J. M.; Hartwigsen, G.; Lim, J.-S.; Bae, H.-J.; Yu, K.-H.; Schlaug, G.; Bonkhoff, A. K.; Rost, N. S.; Bzdok, D.

10.1101/2022.01.18.474989 — neuroscience — Posted on 2022-01-18

1879 Phylovar: Towards scalable phylogeny-aware inference of single-nucleotide variations from single-cell DNA sequencing data

Edrisi, M.; Valecha, M.; Chowdary, S.; Robledo, S.; Ogilvie, H.; Posada, D.; Zafar, H.; Nakhleh, L.

10.1101/2022.01.16.476509 — cancer biology — Posted on 2022-01-18

1880 RASCL: Rapid Assessment Of SARS-CoV-2 Clades Through Molecular Sequence Analysis

Lucaci, A. G.; Zehr, J. D.; Shank, S. D.; Bouvier, D.; Mei, H.; Nekrutenko, A.; Martin, D. P.; Pond, S.

10.1101/2022.01.15.476448 — bioinformatics — Posted on 2022-01-18

1881 Immunokinetic Model for COVID-19 Patients

Fadaei, Y.; Rihan, F. A.; Gandhi, R.

10.1101/2022.01.13.476252 — bioengineering — Posted on 2022-01-18

1882 Cell viability assessment associated with a contact of gas bubbles produced by femtosecond laser breakdown in cell culture media

yasukuni, r.; Koyanagi, A.; Tanaka, Y.; Okano, K.; Hosokawa, Y.

10.1101/2022.01.16.473385 — bioengineering — Posted on 2022-01-18

1883 Capturing the signalling dynamics of the MAPK-AKT-mTOR pathway in a single targeted phosphoproteomics assay

Debets, D. O.; Valverde, J. M.; Altelaar, M.

10.1101/2022.01.17.476555 — cell biology — Posted on 2022-01-18

1884 Avobenzone, Guaiazulene and Tioxolone identified as potent autophagy inducers in a high-throughput image based screen for autophagy flux

Prajapat, S. K.; Subramani, C.; Vrati, S.; Kalia, M.

10.1101/2022.01.17.476702 — cell biology — Posted on 2022-01-18

1885 The Idiopathic Pulmonary Fibrosis-associated single nucleotide polymorphism rs35705950 is transcribed in a MUC5B PromoterAssociated Long Non-Coding RNA(AC061979.1)

Neatu, R.; Thompson, D. J.; Enekwa, I.; Schwalbe, E. C.; Fois, G.; Frick, M.; Braubach, P.; Moschos, S. A.

10.1101/2022.01.18.476727 — cell biology — Posted on 2022-01-18

1886 Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation

Sherpa, D.; Mueller, J.; Karayel, O.; Chrustowicz, J.; Xu, P.; Gottemukkala, K. V.; Baumann, C.; Gross, A.; Czarnezki, O.; Zhang, W.; Gu, J.; Nilvebrant, J.; Weiss, M. J.; Sidhu, S.; Murray, P. J.; Mann, M.; Schulman, B.; Alpi, A. F.

10.1101/2022.01.18.476717 — cell biology — Posted on 2022-01-18

1887 Second Climate Survey of Biomedical PhD Students in the Time of Covid

Ramadoss, D.; Horn, J. P.

10.1101/2022.01.13.476194 — scientific communication and education — Posted on 2022-01-18

1888 Differential Impact of Doxorubicin Dose on Cell Death and Autophagy Pathways during Acute Cardiotoxicity.

Kawalec, P.; Martens, M. D.; Field, J. T.; Mughal, W.; Caymo, A. M.; Chapman, D.; Xiang, B.; Ghavami, S.; Dolinsky, V. W.; Gordon, J.

10.1101/2022.01.15.476450 — physiology — Posted on 2022-01-18

1889 MutSigCVsyn: Identification of Thirty Synonymous Cancer Drivers

Rao, Y.; Ahmed, N.; Pritchard, J.; O'Brien, E.

10.1101/2022.01.16.476507 — bioinformatics — Posted on 2022-01-18

1890 Single-sequence protein structure prediction using supervised transformer protein language models

Wang, W.; Peng, Z.; Yang, J.

10.1101/2022.01.15.476476 — bioinformatics — Posted on 2022-01-18

1891 NIMAA: an R/CRAN package to accomplish NomInal data Mining AnAlysis

Jafari, M.; Chen, C.; Mirzaie, M.; Tang, J.

10.1101/2022.01.13.475835 — bioinformatics — Posted on 2022-01-18

1892 scSampler: fast diversity-preserving subsampling of large-scale single-cell transcriptomic data

Song, D.; Xi, N. M.; Li, J. J.; Wang, L.

10.1101/2022.01.15.476407 — bioinformatics — Posted on 2022-01-18

1893 MERIT: controlling Monte-Carlo error rate in large-scale Monte-Carlo hypothesis testing

Li, Y.; Hu, Y.; Satten, G. A.

10.1101/2022.01.15.476485 — bioinformatics — Posted on 2022-01-18

1894 Engineering Rotating Apical-Out Airway Organoid for Assessing Respiratory Cilia Motility

Wijesekara, P.; Yadav, P.; Perkins, L. A.; Stolz, D.; Franks, J. M.; Watkins, S.; Jacome, E. R.; Brody, S. L.; Horani, A.; Xu, J.; Barati farimani, A.; Ren, X.

10.1101/2022.01.15.476455 — bioengineering — Posted on 2022-01-18

1895 On the Edge: Identifying priority areas for conservation of Fishing Cat, a threatened wetland felid, amidst rapidly altering freshwater landscapes

Adhya, T.; Bagaria, P.; Dey, P.; Munoz, V. H.; Ratnayaka, A. A. W.; Thudugala, A.; N.A, A.; Sanderson, J. G.

10.1101/2022.01.16.476498 — ecology — Posted on 2022-01-18

1896 Entamoeba histolytica EHD1 is involved in mitosome-endosome contact

Santos, H. J.; Hanadate, Y.; Imai, K.; Watanabe, H.; Nozaki, T.

10.1101/2022.01.16.476539 — cell biology — Posted on 2022-01-18

1897 Dual Specificity Phosphatase 7 Drives the Formation of Cardiac Mesoderm in Mouse Embryonic Stem Cells

Sladecek, S.; Radaszkiewicz, K. A.; Bohmova, M.; Gybel, T.; Radaszkiewicz, T. W.; Pachernik, J.

10.1101/2022.01.18.476715 — cell biology — Posted on 2022-01-18

1898 Multiplexed imaging mass cytometry reveals distincttumor-immune microenvironments linked to immunotherapyresponses in melanoma

Xiao, X.; Guo, Q.; Cui, C.; Lin, Y.; Zhang, L.; Ding, X.; Li, Q.; Wang, M.; Yang, W.; Kong, Y.; Yu, R.

10.1101/2022.01.15.476480 — immunology — Posted on 2022-01-18

1899 Analog of the Hutchinson equation in biophysical neurodynamics: from the Morris-Lecar model to a delay differential equation

Paraskevov, A. V.

10.1101/2022.01.15.476459 — neuroscience — Posted on 2022-01-18

1900 Cell morphological profiling enables high-throughput screening for PROteolysis TArgeting Chimera (PROTAC) phenotypic signature

Moreau, K.; Trapotsi, M.-A.; Mouchet, E.; Williams, G.; Monteverde, T.; Juhani, K.; Turkki, R.; Miljkovic, F.; Martinsson, A.; Mervin, L.; Mullers, E.; Barrett, I.; Engkvist, O.; Bender, A.

10.1101/2022.01.17.476610 — pharmacology and toxicology — Posted on 2022-01-18

1901 A new method for the sampling and preservation of placental specimens in low-resource settings for histology and analysis of nucleic acids

Strassmann, B. I.; Potoczak, P. S.; Rysenga, C.; Lieberman, R. W.; Vincenz, C.

10.1101/2022.01.12.476059 — pathology — Posted on 2022-01-18

1902 Hidden multiplicity in the analysis of variance (ANOVA): multiple contrast tests as an alternative

Hothorn, L. A.

10.1101/2022.01.15.476452 — bioinformatics — Posted on 2022-01-18

1903 Spatially resolved single-cell deconvolution of bulk RNA-seq using Bulk2Space

Liao, J.; Qian, J.; Fang, Y.; Chen, Z.; Zhuang, X.; Zhang, N.; Shao, X.; Yang, H.; Yang, P.; Cheng, J.; Hu, Y.; Hu, Y.; Yu, L.; Zhang, J.; Lu, X.; Shao, L.; Wu, D.; Gao, Y.; Chen, H.; Fan, X.

10.1101/2022.01.15.476472 — bioinformatics — Posted on 2022-01-18

1904 3D MRI atlases of congenital aortic arch anomalies and normal fetal heart: application to automated multi-label segmentation

Uus, A.; van Poppel, M. P. M.; Steinweg, J. K.; Grigorescu, I.; Egloff Collado, A.; Ramirez Gilliland, P.; Roberts, T. A.; Hajnal, J. V.; Rutherford, M. A.; Lloyd, D. F. A.; Pushparajah, K.; Deprez, M.

10.1101/2022.01.16.476503 — bioinformatics — Posted on 2022-01-18

1905 Data-driven extraction of human kinase-substrate relationships from omics datasets

Petursson, B.; Petsalaki, E.

10.1101/2022.01.15.476449 — bioinformatics — Posted on 2022-01-18

1906 Yeast biopanning for detecting antibody binding to site-specific phosphorylations in tau

Arbaciauskaite, M.; Pirhanov, A.; Lei, Y.; Cho, Y. K.

10.1101/2022.01.15.476481 — bioengineering — Posted on 2022-01-18

1907 Wireless closed-loop smart bandage for chronic wound management and accelerated tissue regeneration

Jiang, Y.; Trotsyuk, A.; Niu, S.; Henn, D.; Chen, K.; Shih, C.-C.; Larson, M.; Mermin-Bunnell, A.; Mittal, S.; Lai, J.-C.; Saberi, A.; Beard, E.; Jing, S.; Zhong, D.; Steele, S.; Sun, K.; Jain, T.; Zhao, E.; Neimeth, C.; Viana, W.; Tang, J.; Sivaraj, D.; Padmanabhan, J.; Rodrigues, M.; Perrault, D.; Chattopadhyay, A.; Maan, Z.; Leeolou, M.; Bonham, C.; Kwon, S. H.; Kussie, H.; Fischer, K.; Gurusankar, G.; Liang, K.; Zhang, K.; Nag, R.; Snyder, M.; Januszyk, M.; Gurtner, G.; Bao, Z.

10.1101/2022.01.16.476432 — bioengineering — Posted on 2022-01-18

1908 Topological supramolecular network enabled highly conductive and stretchable organic bioelectronics

Jiang, Y.; Zhang, Z.; Wang, Y.-X.; Li, D.; Coen, C.-T.; Hwaun, E.; Chen, G.; Wu, H.-C.; Zhong, D.; Niu, S.; Wang, W.; Saberi, A.; Lai, J.-C.; Wang, Y.; Trotsyuk, A.; Loh, K. Y.; Shih, C.-C.; Xu, W.; Liang, K.; Zhang, K.; Hu, W.; Jia, W.; Cheng, Z.; Dauskardt, R.; Gurtner, G.; Tok, J.; Deisseroth, K.; Soltesz, I.; Bao, Z.

10.1101/2022.01.16.476423 — bioengineering — Posted on 2022-01-18

1909 Strategies of invertebrate osmoregulation: an evolutionary blueprint for transmuting into fresh water from the sea

McNamara, J. C.; Freire, C. A.

10.1101/2022.01.16.476502 — evolutionary biology — Posted on 2022-01-18

1910 Rapid and repeatable genome evolution across three hybrid ant populations

Nouhaud, P.; Martin, S. H.; Portinha, B.; Sousa, V. C.; Kulmuni, J.

10.1101/2022.01.16.476493 — evolutionary biology — Posted on 2022-01-18

1911 Divergent sex-specific effects of an IgE receptor polymorphism: from immunity to health, and ultimately, fitness

Wanelik, K. M.; Begon, M.; Bradley, J. E.; Friberg, I. M.; Jackson, J. A.; Taylor, C. H.; Paterson, S.

10.1101/841825 — ecology — Posted on 2022-01-18

1912 Occurrence Of Avian Reovirus And Picobirnavirus In Wild Birds In An Environmental Protection Area In The Amazon Biome, Para, Brazil

Pereira, D.; Souto, L. C. d. S.; Guerra, S. d. F. d. S.; Penha Junior, E. T. d.; Lobo, P. d. S.; Soares, L. d. S.; Pinheiro, H. H. C.; Chagas, E. H. N.; Ramos, B. A.; Chagas, L. L. d.; Freitas, M. N. O.; Furtado, E. C. d. S.; Rodrigues, J. C. P.; Casseb, A. d. R.; Martins, L. C.; Mascarenhas, J. D. P.

10.1101/2022.01.11.475455 — microbiology — Posted on 2022-01-18

1913 Dietary butyrate treatment enhances healthy metabolites by longitudinal untargeted metabolomic analysis in amyotrophic lateral sclerosis mice

Ogbu, D.; Zhang, Y.-g.; Claud, K.; Xia, Y.; Sun, J.

10.1101/2022.01.15.476456 — physiology — Posted on 2022-01-18

1914 How to characterise shared space use networks

Wanelik, K. M.; Farine, D. R.

10.1101/839530 — ecology — Posted on 2022-01-18

1915 Genomic landscape of drug response reveals novel mediators of anthelmintic resistance

Doyle, S. R.; Laing, R.; Bartley, D.; Morrison, A.; Holroyd, N.; Maitland, K.; Antonopoulos, A.; Chaudhry, U.; Flis, I.; Howell, S.; McIntyre, J.; Gilleard, J. S.; Tait, A.; Mable, B. K.; Kaplan, R.; Sargison, N.; Britton, C.; Berriman, M.; Devaney, E.; Cotton, J.

10.1101/2021.11.12.465712 — genomics — Posted on 2022-01-18

1916 The interaction between a parasite and sub-optimal temperatures contributes to honey bee decline

Frizzera, D.; Andreuzza, L.; Boaro, G.; D'Agaro, M.; Del Fabbro, S.; Zanni, V.; Annoscia, D.; Nazzi, F.

10.1101/2021.07.22.453350 — ecology — Posted on 2022-01-18

1917 The secreted metabolome of HeLa cells under effect of Crotamine, a cell-penetrating peptide from a rattlesnake using NMR-based metabolomics analyses

Coronado, M. A.; de Moraes, F. R.; Stuqui, B.; Calmon, M. F.; Eberle, R. J.; Rahal, P.; Arni, R. K.

10.1101/2022.01.15.476435 — cell biology — Posted on 2022-01-18

1918 The Salmonella transmembrane effector SteD hijacks AP1-mediated vesicular trafficking for delivery to antigen-loading MHCII compartments

Godlee, C.; Cerny, O.; Liu, M.; Blundell, S.; Gallagher, A. E.; Shahin, M.; Holden, D. W.

10.1101/2022.01.10.475600 — microbiology — Posted on 2022-01-18

1919 Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction

Sugihara, K.; Kitamoto, S.; Saraithong, P.; Nagao-Kitamoto, H.; Hoostal, M.; Rosevelt, A.; Muraleedharan, C. K.; Gillilland, M. G.; Imai, J.; Omi, M.; Bishu, S.; Kao, J. Y.; Alteri, C.; Barnich, N.; Schmidt, T. M.; Nusrat, A.; Inohara, N.; Golob, J. L.; Kamada, N.

10.1101/2022.01.17.476631 — microbiology — Posted on 2022-01-18

1920 Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens

Buckley, P.; Ma, R.; Lee, C. H.-J.; Woodhouse, I.; Woo, J.; Tsvetkov, V. O.; Shcherbinin, D. S.; Shugay, M.; Rei, M.; Simmons, A.; Koohy, H.

10.1101/2020.12.25.424183 — immunology — Posted on 2022-01-18

1921 Non-Coding Genetic Analysis Implicates Interleukin 18 Receptor Accessory Protein 3'UTR in Amyotrophic Lateral Sclerosis

Eitan, C.; Siany, A.; Barkan, E.; Olender, T.; van Eijk, K. R.; Moisse, M.; Farhan, S. M. K.; Danino, Y. M.; Yanowski, E.; Marmor-Kollet, H.; Rivkin, N.; Yacovzada, N.; Hung, S.-T.; Cooper-Knock, J.; Yu, C.-H.; Louis, C.; Masters, S. L.; Kenna, K. P.; van der Spek, R. A. A.; Sproviero, W.; Al Khleifat, A.; Iacoangeli, A.; Shatunov, A. S.; Jones, A. R.; Elbaz-Alon, Y.; Cohen, Y.; Chapnik, E.; Rothschild, D.; Weissbrod, O.; Beck, G.; Ainbinder, E.; Ben-Dor, S.; Werneburg, S.; Schafer, D. P.; Brown, R. H.; Shaw, P. J.; Van Damme, P.; van den Berg, L. H.; Phatnani, H. P.; Segal, E.; Ichida, J. K.;

10.1101/2021.06.03.446863 — neuroscience — Posted on 2022-01-18

1922 Illusory tactile movement crosses arms and legs and is coded in external space

Martel, M.; Fuchs, X.; Trojan, J.; Gockel, V.; Habets, B.; Heed, T.

10.1101/2021.05.20.445020 — neuroscience — Posted on 2022-01-18

1923 Improving the robustness of engineered bacteria to nutrient stress using programmed proteolysis

Szydlo, K.; Ignatova, Z.; Gorochowski, T. E.

10.1101/2021.10.04.463040 — synthetic biology — Posted on 2022-01-18

1924 Differential remodelling in small and large murine airways revealed by novel whole lung airway analysis.

Tatler, A. L.; Philp, C. J.; Hill, M. R.; Cox, S.; Bullock, A.; Habgood, A.; John, A.; Middlewick, R.; Stephenson, K. E.; Goodwin, A. T.; Billington, C. K.; O'Dea, R. D.; Brook, B. S.; Johnson, S. R.

10.1101/2022.01.15.476324 — physiology — Posted on 2022-01-18

1925 Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models

Sauer, C. M.; Heider, K.; Belic, J.; Boyle, S. E.; Hall, J. A.; Couturier, D.-L.; An, A.; Vijayaraghavan, A.; Reinius, M. A.; Hosking, K.; Vias, M.; Rosenfeld, N.; Brenton, J. D.

10.1101/2022.01.15.476442 — cancer biology — Posted on 2022-01-18

1926 m6A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small cell lung cancer

Tsuchiya, K.; Yoshimura, K.; Iwashita, Y.; Inoue, Y.; Ohta, T.; Watanabe, H.; Yamada, H.; Kawase, A.; Tanahashi, M.; Ogawa, H.; Funai, K.; Shinmura, K.; Suda, T.; Sugimura, H.

10.1101/2021.07.06.451216 — cancer biology — Posted on 2022-01-18

1927 Optimized phylogenetic clustering of HIV-1 sequence data for public health applications

Chato, C.; Feng, Y.; Ruan, Y.; Xing, H.; Herbeck, J.; Kalish, M.; Poon, A.

10.1101/2022.01.14.476062 — bioinformatics — Posted on 2022-01-18

1928 Sparse and Skew Hashing of K-Mers

Pibiri, G. E.

10.1101/2022.01.15.476199 — bioinformatics — Posted on 2022-01-18

1929 Hierarchical autoencoder-based integration improves performance in multi-omics cancer survival models through soft modality selection

Wissel, D.; Rowson, D.; Boeva, V.

10.1101/2021.09.16.460589 — bioinformatics — Posted on 2022-01-18

1930 Embedded 3D printing in self-healing annealable composites for precise patterning of functionally mature human neural constructs

10.1101/2021.08.04.455135 — bioengineering — Posted on 2022-01-18

1931 Reduction of free-roaming cat population requires high-intensity neutering in spatial contiguity to mitigate compensatory effects

Gunther, I.; Hawlena, H.; Azriel, L.; Gibor, D.; Berke, O.; Klement, E.

10.1101/2021.12.02.470990 — ecology — Posted on 2022-01-18

1932 Catch bond models explain how force amplifies TCR signaling and antigen discrimination

Choi, H.-K.; Li, K.; Rushdi, M. N.; Ge, C.; Chen, W.; Lou, J.; Zhu, C.

10.1101/2022.01.17.476694 — biophysics — Posted on 2022-01-18

1933 Mucosal associated invariant T cells are altered in patients with Hidradenitis Suppurativa and contribute to the inflammatory milieu

Gallagher, C.; MacMahon, J.; O'Neill, C.; Cassidy, F. C.; Dunbar, H.; DeBarra, C.; Cadden, C.; Pisarska, M. M.; Wood, N. A.; Masterson, J. C.; McNamee, E. N.; English, K.; O'Shea, D.; Tobin, A.-M.; Hogan, A. E.

10.1101/2022.01.17.476587 — immunology — Posted on 2022-01-18

1934 Light activation of Orange Carotenoid Protein reveals initial C8'-C7' double bond trans/cis photoisomerization

Chukhutsina, V.; Baxter, J.; Fadini, A.; Morgan, R. M.; Pope, M.; Maghlaoui, K.; Orr, C.; Wagner, A.; van Thor, J.

10.1101/2022.01.17.475858 — biophysics — Posted on 2022-01-18

1935 Quantitative Models of Lipid Transfer and Membrane Contact Formation

Zhang, Y.; Ge, J.; Bian, X.; Kumar, A.

10.1101/2022.01.17.476625 — biophysics — Posted on 2022-01-18

1936 Curation, inference, and assessment of a globally reconstructed gene regulatory network for Streptomyces coelicolor

Zorro-Aranda, A.; Escorcia-Rodriguez, J. M.; Gonzalez-Kise, J. K.; Freyre-Gonzalez, J. A.

10.1101/2021.11.26.470080 — systems biology — Posted on 2022-01-18

1937 Direct Observation of Heterogeneous Formation of Amyloid Spherulites in Real-time by Super-resolution Microscopy

Zhang, M.; Pinholt, H. D.; Zhou, X.; Bohr, S. S.-R.; Banneta, L.; Zaccone, A.; Fodera, V.; Hatzakis, N. S.

10.1101/2021.08.20.457097 — biophysics — Posted on 2022-01-18

1938 Collateral cleavage of 28s rRNA by RfxCas13d causes death of mice

Li, Y.; Xu, J.; Guo, X.; Li, Z.; Cao, L.; Liu, S.; Guo, Y.; Wang, G.; Luo, Y.; Zhang, Z.; Wei, X.; Zhao, Y.; Liu, T.; Wang, X.; Xia, H.; Kuang, M.; Guo, Q.; Li, J.; Chen, L.; Wang, Y.; Li, Q.; Wang, F.; Liu, Q.; You, F.

10.1101/2022.01.17.476700 — bioengineering — Posted on 2022-01-18

1939 Broad-spectrum mono- and combinational drug therapies for global viral pandemic preparedness

Ianevski, A.; Yao, R.; Simonsen, R. M.; Myhre, V.; Ravlo, E.; Kaynova, G. D.; Zusinaite, E.; White, J. M.; Pan, Q.; Polyak, S. J.; Oksenych, V.; Windisch, M. P.; Lastauskiene, E.; Vitkauskiene, A.; Matukevicius, A.; Tenson, T.; Bjoras, M.; Kainov, D. E.

10.1101/2022.01.15.476444 — microbiology — Posted on 2022-01-18

1940 A hippocampal-hypothalamic circuit essential for anxiety-related behavioral avoidance

Xu, X.-H.; Yan, J.-j.; Chen, A.-X.; Zhang, W.; He, T.; Ding, X.-J.; Yu, Z.-X.; Zhang, Y.-L.; He, M.; Li, H.

10.1101/2022.01.17.476545 — neuroscience — Posted on 2022-01-18

1941 Brainwide input-output architecture of paraventricular oxytocin and vasopressin neurons

Freda, S.; Priest, M.; Badong, D.; Xiao, L.; Liu, Y.; Kozorovitskiy, Y.

10.1101/2022.01.17.476652 — neuroscience — Posted on 2022-01-18

1942 Post-encoding reactivation promotes one-shot learning of episodes in humans

Wu, X.; Vinals, X.; Ben-Yakov, A.; Staresina, B.; Fuentemilla, L.

10.1101/2021.04.13.439658 — neuroscience — Posted on 2022-01-18

1943 A remote lecture series roadmap to equity, diversity, and inclusion in STEM

Boyle, E. A.; Goldberg, G.; Schmok, J. C.; Burgado, J.; Izidro Layng, F.; Grunwald, H. A.; Balotin, K. M.; Cuoco, M. S.; Chang, K.-C.; Ecklu-Mensah, G.; Arakaki, A. K. S.; Ahmed, N.; Garcia Arceo, X.; Jagannatha, P.; Pekar, J.; Iyer, M.; DASL Alliance, ; Yeo, G. W.

10.1101/2021.12.05.471284 — scientific communication and education — Posted on 2022-01-18

1944 Criticality and network structure drive emergent oscillations in a stochastic whole-brain model

Barzon, G.; Nicoletti, G.; Mariani, B.; Formentin, M.; Suweis, S.

10.1101/2022.01.17.476567 — neuroscience — Posted on 2022-01-18

1945 Task-specific neural processes underlying conflict resolution during cognitive control

Xiao, Y.; Chou, C.-C.; Cosgrove, G. R.; Crone, N. E.; Stone, S.; Madsen, J. R.; Reucroft, I.; Weisholtz, D.; Shih, Y.-C.; Yu, H.-Y.; Anderson, W. S.; Kreiman, G.

10.1101/2022.01.16.476535 — neuroscience — Posted on 2022-01-18

1946 A quantitative analysis of the similarities and differences of the HIV/FIV gag genome

Siu, C.; Horn, M.; Cheng, X. W.

10.1101/2022.01.17.476666 — microbiology — Posted on 2022-01-17

1947 The Streptococcus agalactiae R3 surface protein is encoded by sar5

Dragset, M. S.; Basson, A.; Olaisen, C.; Selvik, L.-K.; Lyng, R. V.; Lysvand, H.; Aas, C. G.; Afset, J. E.

10.1101/2022.01.17.476664 — microbiology — Posted on 2022-01-17

1948 The voltage-gated Cav Ca2+ channel subunit α2δ-4 is required for locomotor behavior and sensorimotor gating in mice

Klomp, A.; Lee, A.; Omichi, R.; Iwasa, Y.; Smith, R.; Usachev, Y.; Russo, A.; Narayanan, N.

10.1101/2022.01.17.476669 — neuroscience — Posted on 2022-01-17

1949 Comparative study of the unbinding process of some HTLV-1 protease inhibitors using Unbiased Molecular Dynamics simulation

Aryapour, H.; Tiyoula, F. N.; Moghadam, M. J.

10.1101/2022.01.17.476663 — bioinformatics — Posted on 2022-01-17

1950 Discrimination of edge orientation by bumblebees

Guiraud, M. G. S.; Roper, M.; Wolf, S.; Woodgate, J. L.; Chittka, L.

10.1101/2022.01.17.476662 — animal behavior and cognition — Posted on 2022-01-17

1951 Basis of narrow-spectrum activity of fidaxomicin on gut pathogen Clostridioides difficile

Cao, X.; Boyaci, H.; Chen, J.; Bao, Y.; Landick, R.; Campbell, E. A.

10.1101/2022.01.17.476619 — microbiology — Posted on 2022-01-17

1952 A deep learning pipeline for segmentation of Proteus mirabilis colony patterns

Doshi, A.; Shaw, M.; Tonea, R.; Minyety, R.; Moon, S.; Laine, A.; Guo, J.; Danino, T.

10.1101/2022.01.17.475672 — microbiology — Posted on 2022-01-17

1953 Tuftsin: a natural molecule against SARS-CoV-2 infection

Huang, J.; Wang, J.; Wang, Z.; Chu, M.; Wang, Y.

10.1101/2022.01.10.475746 — immunology — Posted on 2022-01-17

1954 Synchronized Neural Activity Indexes Engagement with Spoken Stories Despite Acoustic Masking

Irsik, V. C.; Johnsrude, I.; Herrmann, B.

10.1101/2021.03.25.437022 — neuroscience — Posted on 2022-01-17

1955 The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

Banse, S. A.; Jackson, E. G.; Sedore, C. A.; Onken, B.; Hall, D.; Coleman-Hulbert, A. L.; Huynh, P.; Garrett, T.; Johnson, E.; Harinath, G.; Inman, D.; Guo, S.; Morshead, M.; Xue, J.; Falkowski, R.; Chen, E.; Herrera, C.; Kirsch, A. J.; Perez, V. I.; Guo, M.; Lithgow, G. J.; Driscoll, M.; Phillips, P. C.

10.1101/2022.01.15.476462 — physiology — Posted on 2022-01-17

1956 Augmentation of extracellular ATP synergizes with chemotherapy in triple negative breast cancer

Manouchehri, J. M.; Datta, J.; Willingham, N.; Wesolowski, R.; Stover, D. A.; Ganju, R. K.; Carson, W.; Ramaswamy, B.; Cherian, M. A.

10.1101/2022.01.11.475873 — cancer biology — Posted on 2022-01-17

1957 Mechanosensitive Osteogenesis on Native Cellulose Scaffolds for Bone Tissue Engineering.

Leblanc Latour, M.; Pelling, A. E.

10.1101/2021.05.26.444470 — biophysics — Posted on 2022-01-17

1958 Lightweight compositional analysis of metagenomes with FracMinHash and minimum metagenome covers

Irber, L. C.; Brooks, P. T.; Reiter, T. E.; Pierce-Ward, N. T.; Hera, M. R.; Koslicki, D.; Brown, C. T.

10.1101/2022.01.11.475838 — bioinformatics — Posted on 2022-01-17

1959 The genetic and ecological landscape of plasmids in the human gut

Yu, M. K.; Fogarty, E. C.; Eren, A. M.

10.1101/2020.11.01.361691 — bioinformatics — Posted on 2022-01-17

1960 Testing the maintenance of natural responses to survival-relevant calls in the conservation breeding population of a critically endangered corvid (Corvus hawaiiensis)

Sabol, A. C.; Greggor, A. L.; Masuda, B.; Swaisgood, R. R.

10.1101/2021.05.24.445466 — animal behavior and cognition — Posted on 2022-01-17

1961 Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity

Izgi, H.; Han, D.; Isildak, U.; Huang, S.; Kocabiyik, E.; Khaitovich, P.; Somel, M.; Dönertas, H. M.

10.1101/2021.03.02.432281 — genomics — Posted on 2022-01-17

1962 Genome sequence data reveal at least two distinct incursions of the tropical race 4 (TR4) variant of Fusarium wilt into South America

Reyes-Herrera, P. H.; Torres-Bedoya, E.; Lopez-Alvarez, D.; Burbano-David, D.; Carmona, S. L.; Bebber, D. P.; Studholme, D. J.; Betancourt, M.; Soto-Suarez, M.

10.1101/2022.01.17.476647 — genomics — Posted on 2022-01-17

1963 User-guided local and global copy-number segmentation for tumor sequencing data

Lalani, Z.; Chu, G.; Hsu, S.; Zaccaria, S.; El-Kebir, M.

10.1101/2022.01.15.476457 — genomics — Posted on 2022-01-17

1964 ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells

Xu, W.; Yang, W.; Zhang, Y.; Chen, Y.; Zhang, Q.; Wang, X.; Song, K.; Jin, W.; Chen, X.

10.1101/2022.01.16.476488 — genomics — Posted on 2022-01-17

1965 A chromosome-scale genome assembly of the false clownfish, Amphiprion ocellaris

Ryu, T.; Herrera, M.; Moore, B.; Izumiyama, M.; Kawai, E.; Laudet, V.; Ravasi, T.

10.1101/2022.01.16.476524 — genomics — Posted on 2022-01-17

1966 Development of efficient RNAi methods in the corn leafhopper Dalbulus maidis, a promising application for pest control

Dalaison, L. I.; Pascual, A.; Gazza, E.; Welchen, E.; Rivera-Pomar, R.; Catalano, M. I.

10.1101/2022.01.17.476645 — genetics — Posted on 2022-01-17

1967 Alien chromatin other than the GST-encoding Fhb7 candidate confers Fusarium head blight resistance in wheat breeding

Guo, X.; Shi, Q.; Yuan, J.; Zhang, J.; Wang, M.; Wang, J.; Wang, C.; Fu, S.; Su, H.; Liu, Y.; Huang, Y.; Liu, C.; Liu, Q.; Sun, Y.; Wang, L.; Wang, K.; Jing, D.; Zhang, P.; Li, J.; Kang, H.; Zhou, Y.; Ye, X.; Han, F.

10.1101/2021.02.03.429547 — genetics — Posted on 2022-01-17

1968 Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats

Justen, H.; Hasselmann, T.; Illera, J. C.; Delmore, K. E.; Serrano, D.; Flinks, H.; Senzaki, M.; Kawamura, K.; Helm, B.; Liedvogel, M.

10.1101/2022.01.15.476482 — genetics — Posted on 2022-01-17

1969 A novel mechanism for left-right asymmetry establishment involving tissue remodeling and MyoID

Lefevre, B. M.; Delvigne, M.; Vidal, J.; Courtier-Orgogozo, V.; Lang, M.

10.1101/2022.01.16.476383 — evolutionary biology — Posted on 2022-01-17

1970 Substantial genetic mixing among sexual and androgenetic lineages within the clam genus Corbicula

Vastrade, M.; Etoundi, E.; Bournonville, T.; Colinet, M.; Debortoli, N.; Hedtke, S. M.; Nicolas, E.; Pigneur, L.-M.; Virgo, J.; Flot, J.-F.; Marescaux, J.; Van Doninck, K.

10.1101/590836 — evolutionary biology — Posted on 2022-01-17

1971 Divergent age-related methylation patterns in long and short-lived mammals

Haghani, A.; Wang, N.; Lu, A. T.; Mozhui, K.; Raj, K.; Yang, X.; Horvath, S.

10.1101/2022.01.16.476530 — evolutionary biology — Posted on 2022-01-17

1972 Exocyst stimulates each step of exocytic SNARE complex assembly and vesicle fusion

Lee, C.; Lepore, D.; Munson, M.; Yoon, T.-Y.

10.1101/2022.01.16.476540 — molecular biology — Posted on 2022-01-17

1973 The oncogene FOXQ1 is a selective activator of Wnt/β-catenin signalling

Pizzolato, G.; Moparthi, L.; Söderholm, S.; Cantu, C.; Koch, S.

10.1101/2022.01.17.476620 — molecular biology — Posted on 2022-01-17

1974 Human tRNA methyltransferase ALKBH8 targets wider repertoire of tRNAs and non-coding RNAs

Cavallin, I.; Bartosovic, M.; Skalicky, T.; Rengaraj, P.; Schmidt-Dengler, M. C.; Drino, A.; Helm, M.; Vanacova, S.

10.1101/2022.01.17.476611 — molecular biology — Posted on 2022-01-17

1975 Estimating plasmid conjugation rates: a new computational tool and a critical comparison of methods

Huisman, J. S.; Benz, F.; Duxbury, S. J. N.; de Visser, J. A. G. M.; Hall, A. R.; Fischer, E. A. J.; Bonhoeffer, S.

10.1101/2020.03.09.980862 — microbiology — Posted on 2022-01-17

1976 ART duration and immunometabolic state determine efficacy of DC-based treatment restoring functional HIV- specific CD8+ T cells in PLWH.

Calvet-Mirabent, M.; Sanchez-Cerrillo, I.; Martin-Cofreces, N.; De La Fuente, H.; Tsukalov, I.; Delgado-Arevalo, C.; Calzada, M. J.; Santos, I.; Sanz, J.; Garcia-Fraile, L.; Sanchez-Madrid, F.; Alfranca, A.; Munoz-Fernandez, M. A.; Buzon, M. J.; Martin-Gayo, E. M.-G.

10.1101/2022.01.14.476403 — immunology — Posted on 2022-01-17

1977 Suppression without inhibition: How retinal computation contributes to saccadic suppression

Idrees, S.; Baumann, M. P.; Korympidou, M. M.; Schubert, T.; Kling, A.; Franke, K.; Hafed, Z. M.; Franke, F.; Münch, T. A.

10.1101/2020.08.21.261198 — neuroscience — Posted on 2022-01-17

1978 Dissociating the neural correlates of subjective visibility from those of decision confidence

Mazor, M.; Dijkstra, N.; Fleming, S. M.

10.1101/2021.06.01.446101 — neuroscience — Posted on 2022-01-17

1979 Recurrent Connections in the Primate Ventral Visual Stream Mediate a Tradeoff Between Task Performance and Network Size During Core Object Recognition

Nayebi, A.; Sagastuy-Brena, J.; Bear, D. M.; Kar, K.; Kubilius, J.; Ganguli, S.; Sussillo, D.; DiCarlo, J. J.; Yamins, D. L. K.

10.1101/2021.02.17.431717 — neuroscience — Posted on 2022-01-17

1980 Neural basis of functional ultrasound signals

Nunez-Elizalde, A. O.; Krumin, M.; Bai Reddy, C.; Montaldo, G.; Urban, A.; Harris, K. D.; Carandini, M.

10.1101/2021.03.31.437915 — neuroscience — Posted on 2022-01-17

1981 Expectation-Based Gist Facilitation: Rapid Scene Understanding and the Role of Top-Down Information

McLean, D.; Renoult, L.; Malcolm, G. L.

10.1101/2021.02.04.429791 — neuroscience — Posted on 2022-01-17

1982 Activation of the dorsal septum increases alcohol consumption in male C57BL/6J mice.

Haun, H. L.; D'Ambrosio, S. L.; Kash, T. L.

10.1101/2022.01.15.476378 — neuroscience — Posted on 2022-01-17

1983 Fragmented Spatial Maps: State Abstraction and Efficient Planning from Surprisal

Klukas, M.; Sharma, S.; Du, Y.; Lozano-Perez, T.; Kaelbling, L. P.; Fiete, I.

10.1101/2021.10.29.466499 — neuroscience — Posted on 2022-01-17

1984 Efficient coding of natural scenes improves neural system identification

Qiu, Y.; Klindt, D. A.; Szatko, K. P.; Gonschorek, D.; Hoefling, L.; Schubert, T.; Busse, L.; Bethge, M.; Euler, T.

10.1101/2022.01.10.475663 — neuroscience — Posted on 2022-01-17

1985 Quantifying the Morphology and Mechanisms of Cancer Progression in 3D in-vitro environments: Integrating Experiments and Multiscale Models

Dimitriou, N. M.; Flores-Torres, S.; Kinsella, J. M.; Mitsis, G. D.

10.1101/2021.11.16.468856 — systems biology — Posted on 2022-01-17

1986 Stomatal anatomy, leaf structure and nutrients of tropical rainforest tree species respond to altitude in a coordinated manner in accordance with the leaf economics spectrum

Weththasinghe, B. T.; Caldera, I.; Sanjeewani, N.; Samarasinghe, D.; Jayasinghe, H.; Wijethunga, A.; De Costa, J.

10.1101/2022.01.16.476499 — plant biology — Posted on 2022-01-17

1987 Comparative Phenotyping of Two Commonly Used Chlamydomonas reinhardtii Background Strains: CC-1690 (21gr) and CC-5325 (the CLiP Mutant Library Background)

Zhang, N.; Pazouki, L.; Nguyen, H.; Jacobshagen, S.; Xia, M.; Klebanovych, A.; Czymmek, K. J.; Zhang, R.

10.1101/2022.01.15.476454 — plant biology — Posted on 2022-01-17

1988 Identification of candidate virulence loci in Striga hermonthica, a devastating parasite of African cereal crops

Qiu, S.; Bradley, J. M.; Zhang, P.; Chaudhuri, R.; Blaxter, M.; Butlin, R. K.; Scholes, J. D.

10.1101/2022.01.13.476148 — plant biology — Posted on 2022-01-17

1989 Blocking Kir6.2 channels with SpTx1 potentiates glucose-stimulated insulin secretion from murine pancreatic β cells and lowers blood glucose in diabetic mice

Lu, Z.; Ramu, Y.; Yamakaze, J.; Zhou, Y.; Hoshi, T.

10.1101/2022.01.16.476512 — physiology — Posted on 2022-01-17

1990 In vivo inactivation of RAD51-mediated homologous recombination leads to premature aging, but not to tumorigenesis

Matos-Rodrigues, G.; Barroca, V.; Muhammad, A.-A.; Allouch, A.; Koundrioukoff, S.; Lewandowski, D.; Despras, E.; Guirouilh-Barbat, J.; Frappart, L.; Kannouche, P.; Dupaigne, P.; Le Cam, E.; Perfettini, J.-L.; Romeo, P.-H.; Debatisse, M.; Jasin, M.; Livera, G.; Martini, E.; Lopez, B. S.

10.1101/2022.01.17.476609 — cancer biology — Posted on 2022-01-17

1991 RT-qPCR as a screening platform for mutational and small molecule impacts on structural stability of RNA tertiary structures

Zafferani, M.; Muralidharan, D.; Hargrove, A. E.

10.1101/2022.01.16.476525 — biophysics — Posted on 2022-01-17

1992 Computational Prediction of Heteromeric Protein Complex Disassembly Order with Hybrid Monte Carlo/Molecular Dynamics Simulation

Kurisaki, I.; Tanaka, S.

10.1101/2022.01.12.476000 — biophysics — Posted on 2022-01-17

1993 Recovering Single-cell Heterogeneity through Information-based Dimensionality Reduction

DeMeo, B. H.; Berger, B.

10.1101/2021.01.19.427303 — bioinformatics — Posted on 2022-01-17

1994 piggyBac-system-mediated genomic integration of large variant libraries for deep mutational scanning in mammalian cells

Zhao, Y.; Li, Y.; Wang, Y.; Su, W.; Li, S.

10.1101/2022.01.17.476579 — bioengineering — Posted on 2022-01-17

1995 An efficient simplified method for the generation of corneal epithelial cells from human pluripotent stem cells

Abdalkader, R.; Kamei, K.-i.

10.1101/2022.01.16.476543 — bioengineering — Posted on 2022-01-17

1996 Crystal Structure of Caskin1/CASK complex reveals the molecular basis of the binding specificity of CASK_CAMK domain and its binding partners

Wang, Y.; Chen, Q.; Jiang, R.; Ye, X.; Wan, J.; Li, J.; Liu, W.

10.1101/2022.01.16.476467 — biochemistry — Posted on 2022-01-17

1997 Thermodynamic analysis of Zα domain-nucleic acid interactions

SRINIVASAN, B.; Kus, K.; Athanasiadis, A.

10.1101/2022.01.17.476573 — biochemistry — Posted on 2022-01-17

1998 Palatal morphology predicts the paleobiology of early salamanders

Jia, J.; Li, G.; Gao, K.-Q.

10.1101/2022.01.17.476642 — evolutionary biology — Posted on 2022-01-17

1999 The central role of the interspecific interactions in the evolution of microbial communities

Raynaud, T.; Blouin, M.; Devers-Lamrani, M.; Garmyn, D.; Spor, A.

10.1101/2022.01.17.476584 — evolutionary biology — Posted on 2022-01-17

2000 Live-cell fluorescence lifetime multiplexing using synthetic fluorescent probes

Frei, M. S.; Koch, B.; Hiblot, J.; Johnsson, K.

10.1101/2022.01.15.476486 — cell biology — Posted on 2022-01-17

2001 Mod(mdg4) variants repress telomeric retrotransposonHeT-A by blocking subtelomeric enhancers

Takeuchi, C.; Yokoshi, M.; Kondo, S.; Shibuya, A.; Saito, K.; Fukaya, T.; Siomi, H.; Iwasaki, Y. W.

10.1101/2022.01.16.476534 — molecular biology — Posted on 2022-01-17

2002 Using strain-resolved analysis to identify contamination in metagenomics data

Lou, Y. C.; Hoff, J.; Olm, M. R.; West-Roberts, J.; Diamond, S.; Firek, B. A.; Morowitz, M. J.; Banfield, J. F.

10.1101/2022.01.16.476537 — microbiology — Posted on 2022-01-17

2003 Out of the blue: the independent activity of sulfur-oxidizers and diatoms mediate the sudden color shift of a tropical river

Arce-Rodriguez, A.; Libby, E.; Castellon, E.; Avendano, R.; Cambronero, J. C.; Vargas, M.; Pieper, D.; Bertilsson, S.; Chavarria, M.; Puente-Sanchez, F.

10.1101/2022.01.17.476333 — microbiology — Posted on 2022-01-17

2004 Conserved Untranslated Regions of Multipartite Viruses: Natural Markers of Novel Viral Genomic Components and Tags of Viral Evolution

Zhang, S.; Yang, C.; Wu, J.; Qiu, Y.; Xuan, Z.; Yang, L.; Liao, R.; Liang, X.; Yu, H.; Ren, F.; Dong, Y.; Xie, X.; Han, Y.; Wu, D.; Ramos-Gonzalez, P. L.; Freitas-Astua, J.; Zhou, C.; Cao, M.

10.1101/2022.01.16.476546 — microbiology — Posted on 2022-01-17

2005 Meta-analysis of the black soldier fly (Hermetia illucens) microbiota based on 16S rRNA gene amplicon sequencing

Ijdema, F.; De Smet, J.; Crauwels, S.; Lievens, B.; Van Campenhout, L.

10.1101/2022.01.17.476578 — microbiology — Posted on 2022-01-17

2006 Rapid exchange of stably bound protein and DNA cargo on a DNA origami receptor

Brown, J. W. P.; Alford, R. G.; Walsh, J. C.; Spinney, R. E.; Xu, S. Y.; Hertel, S.; Berengut, J. F.; Spenkelink, L. M.; van Oijen, A. M.; Boecking, T.; Morris, R. G.; Lee, L. K.

10.1101/2022.01.16.476526 — synthetic biology — Posted on 2022-01-17

2007 DNA Strand Breaks and Gaps Direct Retroviral Integration

Senavirathne, G.; Gardner, A.; London, J.; Fishel, R.; Yoder, K. E.

10.1101/2021.11.17.469012 — biochemistry — Posted on 2022-01-17

2008 Novel MBLs inhibitors screened from FDA-approved drug library restore the susceptibility of carbapenems to NDM-1-harbouring bacteria

Guo, Y.; Liu, H.; Yang, M.; Ding, R.; Gao, Y.; Niu, X.; Deng, X.; Wang, J.; Feng, H.; Qiu, J.

10.1101/2022.01.16.476523 — microbiology — Posted on 2022-01-17

2009 SARS-CoV-2 infection induces soluble platelet activation markers and PAI-1 in the early moderate stage of COVID-19

Al-Tamimi, A. O.; Yusuf, A. M.; Jayakumar, M. N.; Ansari, A. W.; Elhassan, M.; AbdulKarim, F.; Kannan, M.; Halwani, R.; Ahmad, F.

10.1101/2021.08.23.457378 — pathology — Posted on 2022-01-17

2010 MeShClust v3.0: High-quality clustering of DNA sequences using the mean shift algorithm and alignment-free identity scores

Girgis, H. Z.

10.1101/2022.01.15.476464 — bioinformatics — Posted on 2022-01-17

2011 The role of intraspecific competition during post-glacial recolonization: a Norway spruce case study

Tiret, M.; zhou, l.; scheepers, g.; grahn, t.; milesi, p.; lascoux, m.; lundqvist, s.-o.; gil-garcia, r.

10.1101/2022.01.15.476468 — genetics — Posted on 2022-01-17

2012 Human Mucosal Associated Invariant T cell proliferation is dependent on a MYC-SLC7A5-Glycolysis metabolic axis

Kedia-Mehta, N.; Pisarska, M. M.; Rollings, C.; O'Neill, C.; DeBarra, C.; Foley, C.; Wood, N. A.; Wrigley-Kelly, N.; Veerapen, N.; Besra, G. E.; Bergin, R.; Jones, N.; O'Shea, D.; Sinclair, L. V.; Hogan, A. E.

10.1101/2022.01.17.476571 — immunology — Posted on 2022-01-17

2013 Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM1

Grönloh, M. L. B.; Arts, J. J. G.; Palacios Martinez, S.; van der Veen, A. A.; Kempers, L.; van Steen, A. C. I.; Roelofs, J. J. T. H.; Nolte, M. A.; Goedhart, J.; van Buul, J. D.

10.1101/2022.01.14.476297 — immunology — Posted on 2022-01-17

2014 Absence of the fragile X mental retardation protein alters response patterns to sounds in the auditory midbrain

Sibille, J.; Kremkow, J.; Koch, U.

10.1101/2022.01.15.475369 — neuroscience — Posted on 2022-01-17

2015 Glycation renders alpha-synuclein oligomeric strain and modulates microglia activation

Kumari, M.; Kumar, B.; Bisht, K. S.; Maiti, T. K.

10.1101/2022.01.15.476311 — neuroscience — Posted on 2022-01-17

2016 Generic principles of space compartmentalization in protocell patterns

Gires, P.-Y.; Krauss, S. W.; Thampi, M.; Weiss, M.

10.1101/2022.01.17.476586 — biophysics — Posted on 2022-01-17

2017 A biphasic Deep Semi-supervised framework for Suptype Classification and biomarker discovery

Le, H.; Nguyen, V.-M.; Nguyen, Q.-H.; Le, D.-H.

10.1101/2022.01.13.476268 — bioinformatics — Posted on 2022-01-17

2018 Automatic grading of cervical biopsies by combining full and self-supervision

Lubrano di Scandalea, M.; Lazard, T.; Balezo, G.; Bellahsen-Harrar, Y.; Badoual, C.; Berlemont, S.; Walter, T.

10.1101/2022.01.14.476330 — cancer biology — Posted on 2022-01-17

2019 SLiMAn: an integrative web server for exploring short linear motif-mediated interactions in interactomes.

Reys, V. G. , P. ,; Labesse, G.

10.1101/2022.01.14.476361 — bioinformatics — Posted on 2022-01-17

2020 Experimental characterisation of de novoproteins and their unevolved random-sequencecounterparts

Heames, B.; Buchel, F.; Aubel, M.; Tretyachenko, V.; Lange, A.; Bornberg-Bauer, E.; Hlouchova, K.

10.1101/2022.01.14.476368 — evolutionary biology — Posted on 2022-01-17

2021 Assessing the global impact of targeted conservation actions on species abundance

Jellesmark, S.; Blackburn, T. M.; Dove, S.; Geldmann, J.; Visconti, P.; Gregory, R. D.; McRae, L.; Hoffmann, M.

10.1101/2022.01.14.476374 — ecology — Posted on 2022-01-17

2022 Use of object detection in camera trap image identification: assessing a method to rapidly and accurately classify human and animal detections for research and application in recreation ecology

Fennell, M. J. E.; Beirne, C. W.; Burton, C.

10.1101/2022.01.14.476404 — ecology — Posted on 2022-01-17

2023 Temporal control of late replication and coordination of origin firing by self-stabilizing Rif1-PP1 hubs in Drosophila

Cho, C.-Y.; Seller, C. A.; O'Farrell, P. H.

10.1101/2022.01.14.476400 — cell biology — Posted on 2022-01-17

2024 3D multi-color far-red single-molecule localization microscopy with probability-based fluorophore classification

Siemons, M.; Jurriens, D.; Smith, C.; Kapitein, L.

10.1101/2022.01.14.476290 — cell biology — Posted on 2022-01-17

2025 Somatodendritic release of cholecystokinin potentiates GABAergic synapses onto ventral tegmental area dopamine cells

Martinez Damonte, V.; Pomrenze, M. B.; Casper, C.; Wolfden, A. M.; Malenka, R. C.; Kauer, J. A.

10.1101/2022.01.14.476405 — neuroscience — Posted on 2022-01-17

2026 Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation.

Stieger, K. A.; Eles, J. R.; Ludwig, K.; Kozai, T. D. Y.

10.1101/2022.01.14.476351 — neuroscience — Posted on 2022-01-17

2027 Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer

Datta, J.; Willingham, N.; Manouchehri, J.; Schnell, P.; Sheth, M.; David, J. J.; Kassem, M.; Wilson, T. A.; Radomska, H. S.; Coss, C. C.; Bennett, C. E.; Ganju, R. K.; Sardesai, S. D.; Lustberg, M.; Ramaswamy, B.; Stover, D.; Cherian, M. A.

10.1101/2022.01.14.476328 — cancer biology — Posted on 2022-01-17

2028 The minimizer Jaccard estimator is biased and inconsistent

Belbasi, M.; Blanca, A.; Harris, R. S.; Koslicki, D.; Medvedev, P.

10.1101/2022.01.14.476226 — bioinformatics — Posted on 2022-01-17

2029 SELINA: Single-cell Assignment using Multiple-Adversarial Domain Adaptation Network with Large-scale References

Ren, P.; Shi, X.; Dong, X.; Yu, Z.; Ding, X.; Wang, J.; Sun, L.; Yan, Y.; Hu, J.; Zhang, P.; Chen, Q.; Li, T.; Wang, C.

10.1101/2022.01.14.476306 — bioinformatics — Posted on 2022-01-17

2030 conST: an interpretable multi-modal contrastive learning framework for spatial transcriptomics

Zong, Y.; Yu, T.; Wang, X.; Wang, Y.; Hu, Z.; Li, Y.

10.1101/2022.01.14.476408 — bioinformatics — Posted on 2022-01-17

2031 Automated atlas-based multi-label fetal cardiac vesselsegmentation in Congenital Heart Disease

Ramirez, P. M.; Uus, A.; van Poppel, M. P. M.; Grigorescu, I.; Steinweg, J. K.; Lloyd, D. F. A.; Pushparajah, K.; King, A. P.; Deprez, M.

10.1101/2022.01.14.476320 — bioengineering — Posted on 2022-01-17

2032 M-TUBE: a fabrication-free microfluidic device for large-volume bacterial electroporation requiring minimal assembly

Huang, P.-H.; Chen, S.; Shiver, A. L.; Culver, R. N.; Huang, K.; Buie, C. R.

10.1101/2022.01.14.476275 — bioengineering — Posted on 2022-01-17

2033 In vivo Biomechanical Assessment of Iridial Deformations and Muscle Contractions in Human Eyes

Safa, B. N.; Bahrani Fard, M. R.; Ethier, C. R.

10.1101/2022.01.14.476393 — bioengineering — Posted on 2022-01-17

2034 Functional variability in adhesion and flocculation of yeast megasatellite genes

Saguez, C.; Viterbo, D.; Descorps-Declere, S.; Cormack, B. P.; Dujon, B.; Richard, G.-F.

10.1101/2022.01.14.476295 — genetics — Posted on 2022-01-17

2035 Road encroachment mediates species occupancy, trait filtering and dissimilarity of songbird communities

Ascensao, F.; D Amico, M.; Revilla, E.; Pereira, H.

10.1101/2022.01.14.476305 — ecology — Posted on 2022-01-17

2036 Rapid transgenerational adaptation in response to intercropping increases facilitation and reduces competition

Stefan, L.; Engbersen, N.; Schoeb, C.

10.1101/2022.01.14.476288 — ecology — Posted on 2022-01-17

2037 Chemical defense acquired via pharmacophagy can lead to herd protection in a sawfly

SINGH, P.; Grone, N.; Tewes, L. J.; Müller, C.

10.1101/2022.01.14.476300 — ecology — Posted on 2022-01-17

2038 Red harvester ant (Order: Hymenoptera) preference for cover crop seeds in South Texas

Elliott, L.; Rivera, D.; Noval, J. A.; Choudhury, R. A.; Penn, H. J.

10.1101/2022.01.14.476276 — ecology — Posted on 2022-01-17

2039 Comparison of neural population dynamics in the regression subspace between continuous and categorical task parameters

Chen, H.; Kunimatsu, J.; Oya, T.; Imaizumi, Y.; Hori, Y.; Matsumoto, M.; Minamimoto, T.; Naya, Y.; Yamada, H.

10.1101/2022.01.13.476265 — neuroscience — Posted on 2022-01-17

2040 3D-imaging reveals conserved cerebrospinal fluid drainage via meningeal lymphatic vasculature in mice and humans

Jacob, L.; de Brito Neto, J.; Lenck, S.; Corcy, C.; Benbelkacem, F.; Geraldo, L. H. M.; Xu, Y.; Thomas, J.-M.; El Kamouh, M.-R.; Potier, M.-C.; Haik, S.; Lehericy, S.; Eichmann, A.; Thomas, J.-L.

10.1101/2022.01.13.476230 — neuroscience — Posted on 2022-01-17

2041 Maternal immune activation accelerates puberty initiation and alters mechanical allodynia in male and female C57BL6/J mice.

Zhao, X.; Erickson, M.; Mohammed, R.; Kentner, A. C.

10.1101/2022.01.13.476235 — neuroscience — Posted on 2022-01-17

2042 Distinct Inhibitory Pathways Control Velocity and Directional Tuning in the Retina

Summers, M. T.; Feller, M. B.

10.1101/2022.01.13.476257 — neuroscience — Posted on 2022-01-17

2043 Age-induced changes in Mu Opioid Receptor signaling in the midbrain Periaqueductal Gray of male and female rats

Fullerton, E. F.; Karom, M. C.; Murphy, A. Z.

10.1101/2022.01.13.475945 — neuroscience — Posted on 2022-01-17

2044 Systematic Review and Meta-Analysis: Task-based fMRI Studies in Youths with Irritability

Lee, K. S.; Hagan, C.; Hughes, M.; Cotter, G.; McAdam Freud, E.; Kircanski, K.; Brotman, M.; Leibenluft, E.; Tseng, W.-L.

10.1101/2022.01.14.475556 — neuroscience — Posted on 2022-01-17

2045 Imaging cerebral arteries tortuosity and velocities by transcranial Doppler ultrasound is a reliable assessment of brain aneurysm in mouse models

Lebas, H.; Boutigny, A.; Maupu, C.; Salfati, J.; Orset, C.; Mazighi, M.; Bonnin, P.; BOULAFTALI, Y.

10.1101/2022.01.14.476192 — pathology — Posted on 2022-01-17

2046 A comprehensive library of canonical and non-canonical MHC class I antigens for cancer vaccine development.

10.1101/2022.01.13.475872 — bioinformatics — Posted on 2022-01-17

2047 Non-target effects of ten essential oils on the egg-parasitoid Trichogramma evanescens

van Oudenhove, L.; Cazier, A.; Fillaud, M.; Lavoir, A.-V.; Fatnassi, H.; Perez, G.; Calcagno, V.

10.1101/2022.01.14.476310 — ecology — Posted on 2022-01-17

2048 The cold-drought tolerance trade-off in temperate woody plants constrains range size, but not range filling

Puglielli, G.; Tordoni, E.; Humphreys, A.; Kalwij, J. M.; Hutchings, M. J.; Laanisto, L.

10.1101/2021.07.24.453622 — ecology — Posted on 2022-01-17

2049 Comparative analysis of cattle breeds as satellite cell donors for cultured beef

Melzener, L.; Ding, S.; Hueber, R.; Messmer, T.; Zhou, G.; Post, M. J.; Flack, J. E.

10.1101/2022.01.14.476358 — cell biology — Posted on 2022-01-17

2050 The in vivo RNA structurome of the malaria parasite Plasmodium falciparum, a protozoan with an A/T-rich transcriptome

Dumetz, F.; Enright, A. J.; Zhao, J.; Kwok, C. K.; Merrick, C. J.

10.1101/2021.04.29.441925 — microbiology — Posted on 2022-01-17

2051 The oxygen sensor Prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells

Ajouaou, Y.; Azouz, A.; Taquin, A.; Denanglaire, S.; Hussein, H.; Krayem, M.; Andris, F.; Moser, M.; Goriely, S.; Leo, O.

10.1101/2021.03.23.436597 — immunology — Posted on 2022-01-17

2052 Repetition Probability Effects for Chinese Characters and German Words in the Visual Word Form Area

Li, C.; Kovacs, G.

10.1101/2021.11.01.466762 — neuroscience — Posted on 2022-01-17

2053 TMCC2 Associates with Alzheimer's Disease Pathology in the Human Brain

Hopkins, P. C. R.; Troakes, C.; King, A.; Tear, G.

10.1101/2021.08.14.456332 — neuroscience — Posted on 2022-01-17

2054 An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

Boumelha, J.; de Carne Trecesson, S.; Law, E.; Romero-Clavijo, P.; Coelho, M.; Ng, K.; Mugarza, E.; Moore, C.; Rana, S.; Caswell, D.; Murillo, M.; Hancock, D.; Argyris, P.; Brown, W.; Durfee, C.; Larson, L.; Vogel, R.; Alejandro Suarez-Bonnet, A.; Priestnall, S.; East, P.; Ross, S.; Kassiotis, G.; Molina-Arcas, M.; Swanton, C.; Harris, R.; Downward, J.

10.1101/2020.12.22.423126 — cancer biology — Posted on 2022-01-17

2055 Probabilistic modeling of ambient noise in single-cell omics data

Sheng, C.; Lopes, R.; Li, G.; Schuierer, S.; Waldt, A.; Cuttat, R.; Dimitrieva, S.; Kauffmann, A.; Durand, E.; Galli, G. G.; Roma, G.; de Weck, A.

10.1101/2022.01.14.476312 — bioinformatics — Posted on 2022-01-17

2056 Increases in multiple resources promote plant invasion

Zhang, Z.; Liu, Y.; Hardrath, A.; Jin, H.; van Kleunen, M.

10.1101/2021.08.12.456056 — ecology — Posted on 2022-01-17

2057 ZBTB18 inhibits SREBP-dependent fatty acid synthesis by counteracting CTBPs and KDM1A/LSD1 activity in glioblastoma

Ferrarese, R.; Izzo, A.; Andrieux, G.; Lagies, S.; Bartmuss, J. P.; Masilamani, A. P.; Wasilenko, A.; Osti, D.; Faletti, S.; Schulzki, R.; Yuan, S.; Kling, E.; Ribecco, V.; Heiland, H. D.; Tholen, S. G.; Prinz, M.; Pelicci, G.; Kammerer, B.; Boerries, M.; Carro, M. S.

10.1101/2020.04.17.046268 — cancer biology — Posted on 2022-01-17

2058 P2X2 receptor subunit interfaces are missense variant hotspots where mutations tend to increase apparent ATP affinity

Gasparri, F.; Sarkar, D.; Bielickaite, S.; Poulsen, M. H.; Hauser, A.; Pless, S. A.

10.1101/2021.03.26.436616 — biophysics — Posted on 2022-01-17

2059 Comparison of double-stranded and single-stranded cfDNA library construction methods for targeted genome and methylation sequencing

Zheng, J.; Li, Z.; Zhang, X.; Zhang, H.; Zhu, S.; Sun, J.; Wang, Y.

10.1101/2022.01.12.475986 — molecular biology — Posted on 2022-01-17

2060 ElectroEncephaloGraphy robust statistical linear modelling using a single weight per trial

Pernet, C. R.; Rousselet, G. A.; Suay Mas, I.; Martinez, R.; Wilcox, R.; Delorme, A. A.

10.1101/2021.04.27.441629 — neuroscience — Posted on 2022-01-17

2061 Scalable parametric encoding of multiple modalities

Banh, D.; Huang, A.

10.1101/2021.07.09.451779 — bioinformatics — Posted on 2022-01-16

2062 Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain

Buckley, M. T.; Sun, E.; George, B. M.; Liu, L.; Schaum, N.; Xu, L.; Reyes, J. M.; Goodell, M. A.; Weissman, I. L.; Wyss-Coray, T.; Rando, T. A.; Brunet, A.

10.1101/2022.01.10.475747 — genomics — Posted on 2022-01-16

2063 Accounting for errors in data improves timing in single-cell cancer evolution

Chen, K.; Moravec, J. C.; Gavryushkin, A.; Welch, D.; Drummond, A. J.

10.1101/2021.03.17.435906 — evolutionary biology — Posted on 2022-01-16

2064 Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infection

Jang, K. K.; Kaczmarek, M. E.; Dallari, S.; Chen, Y.-H.; Tada, T.; Axelrad, J.; Landau, N. R.; Stapleford, K. A.; Cadwell, K.

10.1101/2021.07.16.452680 — cell biology — Posted on 2022-01-16

2065 Cytosolic Sensor of Bacterial Lipopolysaccharide in Human Macrophages

Rojas-Lopez, M.; Zajac, A. S.; Wood, T. E.; Miller, K. A.; Gil Marques, M. L.; Hachey, A. C.; Kharbanda, V.; Egger, K. T.; Goldberg, M. B.

10.1101/2021.10.22.465470 — microbiology — Posted on 2022-01-16

2066 Bulk and spatially resolved extracellular metabolomics of free-living nitrogen fixation

Smercina, D.; Kim, Y.-M.; Lipton, M.; Velickovic, D.; Hofmockel, K.

10.1101/2022.01.13.476280 — microbiology — Posted on 2022-01-16

2067 Identification of CDRH3 Loops in the Naive B Cell Receptor Repertoire that Can Be Engaged by Candidate Immunogens

Swanson, O.; Beem, J. M.; Rhodes, B.; Wang, A.; Barr, M.; Chen, H.; Parks, R.; Saunders, K. O.; Haynes, B. F.; Wiehe, K.; Azoitei, M. L.

10.1101/2021.12.18.473225 — immunology — Posted on 2022-01-16

2068 Evolution of assortative mating following selective introgression of pigmentation genes between two Drosophila species

David, J. R.; Ferreira, E. A.; Jabaud, L.; Ogereau, D.; Bastide, H.; Yassin, A.

10.1101/2022.01.14.476347 — evolutionary biology — Posted on 2022-01-16

2069 IL-33 regulates age-dependency of long-term immune dysfunction induced by sepsis

Colon, D. F.; Wanderley, C. W.; Turato, W.; Borges, V. F.; Franchin, M.; Castanheira, F. V. S.; Nascimento, D.; Prado, D.; de Lima, M. H.; Volpon, L. C.; Kavaguti, S. K.; Ramalho, F.; Carlotti, A. P.; Carmona, F.; Franklin, B. S.; Alves-Filho, J. C.; Cunha, F. d. Q.

10.1101/2022.01.15.476447 — immunology — Posted on 2022-01-16

2070 Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Nam, A. S.; Dusaj, N.; Izzo, F.; Murali, R.; Myers, R. M.; Mouhieddine, T.; Sotelo, J.; Benbarche, S.; Waarts, M.; Gaiti, F.; Tahri, S.; Levine, R.; Abdel-Wahab, O.; Godley, L. A.; Chaligne, R.; Ghobrial, I. M.; Landau, D.

10.1101/2022.01.14.476225 — cancer biology — Posted on 2022-01-16

2071 Combining LSD1 and JAK-STAT inhibition targets Down syndrome-associated myeloid leukemia at its core

Grimm, J.; Bhayadia, R.; Gack, L.; Heckl, D.; Klusmann, J.-H.

10.1101/2022.01.14.476342 — cancer biology — Posted on 2022-01-16

2072 Multiple parameters shape the 3D chromatin structure of single nuclei

Goetz, M.; Messina, O.; Espinola, S.; Fiche, J.-B.; Nollmann, M.

10.1101/2022.01.16.476319 — biophysics — Posted on 2022-01-16

2073 Memory effects and static disorder reduce information in single-molecule signals

Song, K.; Makarov, D. E.; Vouga, E.

10.1101/2022.01.13.476256 — biophysics — Posted on 2022-01-16

2074 OrganoID: a versatile deep learning platform for organoid image analysis

Matthews, J. M.; Schuster, B.; Kashaf, S. S.; Liu, P.; Bilgic, M.; Rzhetsky, A.; Tay, S.

10.1101/2022.01.13.476248 — bioengineering — Posted on 2022-01-16

2075 Vexitoxins: a novel class of conotoxin-like venom peptides from predatory gastropods of the genus Vexillum

Kuznetsova, K. G.; Zvonareva, S. S.; Ziganshin, R.; Mekhova, E. S.; Dgebuadze, P. Y.; Dinh, Y. T. H.; Nguyen, T. H. T.; Moshkovskii, S. A.; Fedosov, A. E.

10.1101/2022.01.15.476460 — biochemistry — Posted on 2022-01-16

2076 Contrast-enhanced microCT evaluation of degeneration following partial and full width injuries to mouse lumbar intervertebral disc

Walk, R. E.; Moon, H. J.; Tang, S. Y.; Gupta, M. C.

10.1101/2022.01.14.476362 — animal behavior and cognition — Posted on 2022-01-16

2077 Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in an Alzheimer's disease model

Zeng, H.; Huang, J.; Zhou, H.; Meilandt, W. J.; Dejanovic, B.; Zhou, Y.; Bohlen, C. J.; Lee, S.-H.; Ren, J.; Liu, A.; Sheng, H.; Liu, J.; Sheng, M.; Wang, X.

10.1101/2022.01.14.476072 — genomics — Posted on 2022-01-16

2078 A candidate gene cluster for the bioactive natural product gyrophoric acid in lichen-forming fungi

Singh, G.; Calchera, A.; Merges, D.; Valim, H.; Otte, J.; Schmitt, I.; Dal Grande, F.

10.1101/2022.01.14.475839 — genomics — Posted on 2022-01-16

2079 Ancestral sequence reconstructions evaluated by extant sequence cross-validation

Sennett, M.; Theobald, D.

10.1101/2022.01.14.476414 — evolutionary biology — Posted on 2022-01-16

2080 Genome assembly, structural variants, and genetic differentiation between Lake Whitefish young species pairs (Coregonus sp.) with long and short reads

Mérot, C.; Stenløkk, K. S. R.; Venney, C.; Laporte, M.; Moser, M.; Normandeau, E.; Àrnyasi, M.; Kent, M.; Rougeux, C.; Flynn, J. M.; Lien, S.; Bernatchez, L.

10.1101/2022.01.15.476463 — evolutionary biology — Posted on 2022-01-16

2081 A giant virus genome is densely packaged by stable nucleosomes

Bryson, T. D.; De Ioannes, P.; Valencia-Sanchez, M. I.; Henikoff, J. G.; Talbert, P. B.; La Scola, B.; Armache, K.-J.; Henikoff, S.

10.1101/2022.01.15.476465 — evolutionary biology — Posted on 2022-01-16

2082 The cytoplasmic incompatibility Cif proteins from prophage WO modify sperm genome integrity

Kaur, R.; Leigh, B. A.; Ritchie, I. T.; Bordenstein, S. R.

10.1101/2022.01.15.476471 — cell biology — Posted on 2022-01-16

2083 Outer membrane protein A (OmpA) deficient Salmonella Typhimurium displays enhanced susceptibility towards β-lactam antibiotics: third-generation cephalosporins (ceftazidime) and carbapenems (meropenem)

Roy Chowdhury, A.; Mukherjee, D.; Singh, A. K.; Chakravortty, D.

10.1101/2022.01.16.476490 — microbiology — Posted on 2022-01-16

2084 Sugar shock: Probing Streptococcus pyogenes metabolism through bioluminescence imaging

Davis, R. W.; Muse, C.; Eggleston, H.; Hill, M.; Panizzi, P.

10.1101/2022.01.15.476453 — microbiology — Posted on 2022-01-16

2085 Culture and genomic analysis of Symbiopectobacterium purcellii, gen.nov. sp. nov., isolated from the leafhopper Empoasca decipiens

Nadal-Jimenez, P.; Siozios, S.; Halliday, N.; Camara, M.; Hurst, G. D. D.

10.1101/2022.01.15.476461 — microbiology — Posted on 2022-01-16

2086 Microbiomes of hadal fishes contain similar taxa, obligate symbionts, and known piezophiles across trench habitats

Blanton, J. M.; Peoples, L. M.; Gerringer, M. E.; Iacuniello, C. M.; Gallo, N. D.; Linley, T. D.; Jamieson, A. J.; Drazen, J. C.; Bartlett, D. H.; Allen, E. E.

10.1101/2022.01.15.476391 — microbiology — Posted on 2022-01-16

2087 Comprehensive assessment of functional effects of commonly used sweeteners on ex vivo human gut microbiome

Sun, Z.; Wang, W.; Li, L.; Zhang, X.; Ning, Z.; Mayne, J.; Walker, K.; Stintzi, A.; Figeys, D.

10.1101/2022.01.15.474735 — microbiology — Posted on 2022-01-16

2088 Naive arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigen

Ashouri, J. F.; McCarthy, E.; Yu, S.; Perlmutter, N.; Lin, C.; DeRisi, J.; Ye, C. J.; Weiss, A.

10.1101/2022.01.13.476250 — immunology — Posted on 2022-01-16

2089 ART duration and immunometabolic state determine efficacy of DC-based treatment restoring functional HIV- specific CD8+ T cells in Chronic PLWH.

Calvet-Mirabent, M.; Sanchez-Cerrillo, I.; Martin-Cofreces, N.; De La Fuente, H.; Tsukalov, I.; Delgado-Arevalo, C.; Santos, I.; Sanz, J.; Garcia-Fraile, L.; Sanchez-Madrid, F.; Alfranca, A.; Munoz-Fernandez, M. A.; Buzon, M. J.; Martin-Gayo, E. M.-G.

10.1101/2022.01.14.476403 — immunology — Posted on 2022-01-16

2090 B cells discriminate HIV-1 Envelope protein affinities by sensing antigen binding association rates

Hossain, M. A.; Anasti, K.; Watts, B.; Cronin, K.; Kane, A. P.; Edwards, R. J.; Easterhoff, D.; Zhang, J.; Rountree, W.; Ortiz, Y.; Verkoczy, L.; Reth, M.; Alam, S. M.

10.1101/2022.01.14.476215 — immunology — Posted on 2022-01-16

2091 NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli

Wang, A. G.; Son, M.; Thom, N.; Tay, S.

10.1101/2022.01.14.476099 — systems biology — Posted on 2022-01-16

2092 Endothelial Nitric Oxide Synthase (eNOS) S1176 phosphorylation status governs atherosclerotic lesion formation

Lee, M. Y.; Rahman, N.-T.; Sessa, B.

10.1101/2022.01.13.476234 — physiology — Posted on 2022-01-16

2093 Kynurenine metabolism is altered in mdx mice: a potential muscle to brain connection

Copeland, E. N.; Whitley, K. C.; Watson, C. J.; Baranowski, B. J.; Kurgan, N.; MacNeil, A. J.; MacPherson, R. E.; Fajardo, V. A.; Allison, D. J.

10.1101/2022.01.14.476359 — physiology — Posted on 2022-01-16

2094 Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger

Liu, Q.; Zhang, X.; Huang, H.; Chen, Y.; Wang, F.; Hao, A.; Zhan, W.; Mao, Q.; Hu, Y.; Han, L.; Sun, Y.; Zhang, M.; Liu, Z.; Li, G.; Zhang, W.; Shu, Y.; Sun, L.; Chen, Z.

10.1101/2022.01.14.476289 — biophysics — Posted on 2022-01-16

2095 Escherichia coli response to subinhibitory concentration of Colistin: Insights from study of membrane dynamics and morphology.

Ilangumaran Ponmalar, I.; Swain, J.; Basu, J. K.

10.1101/2022.01.16.476501 — biophysics — Posted on 2022-01-16

2096 Structural Insights into Sphingosine-1-phosphate Receptor Activation

Yu, L.; He, L.; Gan, B.; Ti, R.; Xiao, Q.; Hu, H.; Zhu, L.; Wang, S.; Ren, R.

10.1101/2022.01.15.475352 — biochemistry — Posted on 2022-01-16

2097 Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 A resolution

Pellegrino, S.; Dent, K. C.; Spikes, T.; Warren, A. J.

10.1101/2022.01.16.475527 — biochemistry — Posted on 2022-01-16

2098 Metal-binding propensity in the mitochondrial dynamin-related protein 1

Roy, K.; Pucadyil, T.

10.1101/2022.01.15.476484 — biochemistry — Posted on 2022-01-16

2099 Partial sex linkage and linkage disequilibrium on the guppy sex chromosome

Qiu, S.; Yong, L.; Wilson, A.; Croft, D. P.; Graham, C.; Charlesworth, D.

10.1101/2022.01.14.476360 — evolutionary biology — Posted on 2022-01-16

2100 Modeling predicts differences in CAR T cell signaling due to biological variability

Tserunyan, V.; Finley, S. D.

10.1101/2022.01.14.476364 — systems biology — Posted on 2022-01-16

2101 Allopurinol Blocks The Formation And Progression Of Aortic Aneurysm In A Mouse Model Of Marfan Syndrome

Rodriguez-Rovira, I.; Rycke, K. d.; Arce, C.; Perez, B.; Carretereo, A.; Arbones, M.; Teixido-Tura, G.; Gomez-Cabrera, M. C.; Campuzano, V.; Jimenez-Altayo, F.; Egea, G.

10.1101/2021.10.13.464182 — pathology — Posted on 2022-01-16

2102 Investigation of Chordwise Functionally Graded Flexural Rigidity in Flapping Wings Using a Two-Dimensional Pitch-Plunge Model

Reade, J.; Jankauski, M.

10.1101/2021.08.27.457983 — biophysics — Posted on 2022-01-16

2103 Structural Dynamics of Real and Modeled Solanum Stamens: Implications for Pollen Ejection by Buzzing Bees

Jankauski, M.; Ferguson, R.; Russell, A. L.; Buchmann, S.

10.1101/2021.10.25.465809 — biophysics — Posted on 2022-01-16

2104 Using Topological Data Analysis and RRT to Investigate Protein Conformational Spaces

Dehghanpoor, R.; Afrasiabi, F.; Haspel, N.

10.1101/2021.08.16.456547 — bioinformatics — Posted on 2022-01-16

2105 The VINE complex is a VPS9-domain GEF-containing SNX-BAR coat involved in endosomal sorting

Shortill, S. P.; Frier, M. S.; Davey, M.; Conibear, E.

10.1101/2021.11.29.470412 — cell biology — Posted on 2022-01-16

2106 A CNN model with feature integration for MI EEG subject classification in BMI

Roy, A. M.

10.1101/2022.01.05.475058 — neuroscience — Posted on 2022-01-16

2107 TGF-β-R2 is required for HBP induced acute lung injury and vascular leakage for TGF-/Smad/Rho signaling pathway activation

Liu, Z.; Chen, M.; Sun, Y.; Li, X.; Cao, L.; Ma, X.

10.1101/2022.01.14.476433 — molecular biology — Posted on 2022-01-16

2108 Regulation of sexually dimorphic abdominal courtship behaviors in Drosophila by the Tlx/tailless-like nuclear receptor, Dissatisfaction

Duckhorn, J. C.; Cande, J.; Metkus, M. C.; Song, H.; Altamirano, S.; Stern, D.; Shirangi, T. R.

10.1101/2021.08.09.455671 — neuroscience — Posted on 2022-01-16

2109 Bicarbonate Activation of Monomeric Photosystem II-PsbS/Psb27 Complex

Rutherford, A. W.; Fantuzzi, A.; Piano, D.; Haniewicz, P.; Farci, D.; Loi, M. C.; Park, K.; Büchel, C.; Bochtler, M.

10.1101/2022.01.13.476245 — plant biology — Posted on 2022-01-16

2110 Joint actions of diverse transcription factor families establish neuron-type identities and promote enhancer selectivity

Jimeno-Martin, A.; Sousa, E.; Brocal-Ruiz, R.; Daroqui, N.; Maicas, M.; Flames, N.

10.1101/2020.09.04.283036 — neuroscience — Posted on 2022-01-16

2111 specificity : an R package for generalized specificity analysis, with example analyses of Hawaiian foliar endophytic Fungi, human gut microbiome bacteria, and Antarctic glacier bacteria.

Darcy, J. L.; Amend, A. S.; Swift, S. O. I.; Sommers, P. S.; Lozupone, C. A.

10.1101/2021.11.06.467582 — microbiology — Posted on 2022-01-16

2112 Neuronal hemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein.

Santulli, C.; Bon, C.; De Cecco, E.; Codrich, M.; Narkiewicz, J.; Parisse, P.; Perissinotto, F.; Santoro, C.; Persichetti, F.; Legname, G.; Espinoza, S.; Gustincich, S.

10.1101/2021.10.13.464204 — neuroscience — Posted on 2022-01-16

2113 Individual beliefs about temporal continuity explain variation of perceptual biases

Glasauer, S.; Shi, Z.

10.1101/2021.07.13.452167 — neuroscience — Posted on 2022-01-15

2114 Mechanosensitive Osteogenesis on Native Cellulose Scaffolds for Bone Tissue Engineering.

Leblanc Latour, M.; Pelling, A. E.

10.1101/2021.05.26.444470 — biophysics — Posted on 2022-01-15

2115 Two-stage Linked Component Analysis for Joint Decomposition of Multiple Biologically Related Data Sets

Chen, H.; Caffo, B.; Stein-O'Brien, G.; Liu, J.; Langmead, B.; Colantuoni, C.; Xiao, L.

10.1101/2021.03.22.435728 — bioinformatics — Posted on 2022-01-15

2116 Integrating multimodal data through interpretable heterogeneous ensembles

Li, Y.-C.; Wang, L.; Law, J.; Murali, T. M. N.; Pandey, G.

10.1101/2020.05.29.123497 — bioinformatics — Posted on 2022-01-15

2117 Weighted transitivity scores that account for triadic edge similarity in undirected graphs

Peron, G.

10.1101/2022.01.11.475816 — bioinformatics — Posted on 2022-01-15

2118 Transverse and axial resolution of femtosecond laser ablation

Wang, Y. L.; Grooms, N. W. F.; Chung, S. H.

10.1101/2022.01.13.476227 — bioengineering — Posted on 2022-01-15

2119 BitterMatch: Recommendation systems for matching molecules with bitter taste receptors

Margulis, E.; Slavutsky, Y.; Lang, T.; Behrens, M.; Benjamini, Y.; Niv, M. Y.

10.1101/2022.01.13.476205 — biochemistry — Posted on 2022-01-15

2120 The collapse of genetic incompatibilities in hybridizing populations

Xiong, T.; MALLET, J. L.

10.1101/2021.01.08.425971 — evolutionary biology — Posted on 2022-01-15

2121 Negative effects of agricultural intensification on energetic gain rates of a declining aerial insectivore

Garrett, D. R.; Pelletier, F.; Garant, D.; Belisle, M.

10.1101/2021.03.24.436831 — ecology — Posted on 2022-01-15

2122 Multiscale computer model of the spinal dorsal horn reveals changes in network processing associated with chronic pain

Medlock, L.; Sekiguchi, K.; Hong, S.; Dura-Bernal, S.; Lytton, W. W.; Prescott, S. A.

10.1101/2021.06.09.447785 — neuroscience — Posted on 2022-01-15

2123 Population genomic evidence of selection on structural variants in a natural hybrid zone

Zhang, L.; Chaturvedi, S.; Nice, C.; Lucas, L.; Gompert, Z.

10.1101/2022.01.14.476419 — genomics — Posted on 2022-01-15

2124 Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics

Bonaud, A.; Gargowitsch, L.; Gilbert, S.; Rajan, E.; Canales-Herrerias, P.; Stockholm, D.; Rahman, N.; Collins, M.; Hill, D. L.; Alloatti, A.; Alouche, N.; Balor, S.; Soldan, V.; Gillet, D.; Barbier, J.; Bachelerie, F.; Smith, K. G. C.; Bruhns, P.; Amigorena, S.; Balabanian, K.; Linterman, M. A.; Peden, A.; Espeli, M.

10.1101/2022.01.14.476154 — immunology — Posted on 2022-01-15

2125 Mitochondrial and redox modifications in early stages of Huntington disease

Lopes, C.; Ferreira, I. L.; Maranga, C.; Beatriz, M.; Mota, S.; Sereno, J.; Castelhano, J.; Abrunhosa, A.; Oliveira, F.; De Rosa, M.; Hayden, M. R.; Laco, M.; Januario, C.; Castelo Branco, M.; Rego, A. C.

10.1101/2022.01.14.476381 — neuroscience — Posted on 2022-01-15

2126 Role of the circadian clock "Death-Loop" in the DNA damage response underpinning cancer treatment resistance

Vainshelbaum, N. M.; Salmina, K.; Gerashchenko, B. I.; Lazovska, M.; Zayakin, P.; Cragg, M. S.; Pjanova, D.; Erenpreisa, J.

10.1101/2022.01.14.476363 — cancer biology — Posted on 2022-01-15

2127 Phase Separation of Shell Protein and Enzyme: An Insight into the Biogenesis of a Prokaryotic Metabolosome

Kumar, G.; Sinha, S.

10.1101/2022.01.14.476392 — biophysics — Posted on 2022-01-15

2128 Benchmarking software to predict antibiotic resistance phenotypes in shotgun metagenomes using simulated data

Wissel, E. F.; Talbot, B. M.; Johnson, B. A.; Petit, R. A.; Hertzberg, V.; Dunlop, A.; Read, T. D.

10.1101/2022.01.13.476279 — bioinformatics — Posted on 2022-01-15

2129 Structure-Based Survey of the Human Proteome for Opportunities in Proximity Pharmacology

Rovers, E.; Schapira, M.

10.1101/2022.01.13.475779 — bioinformatics — Posted on 2022-01-15

2130 Drug Contraindications in Comorbid Diseases: a Protein Interactome Perspective

Karunakaran, K. B.; Ganapathiraju, M.; Jain, S.; Brahmachari, S.; Balakrishnan, N.

10.1101/2022.01.11.475465 — bioinformatics — Posted on 2022-01-15

2131 Structural Basis for the Calmodulin-Mediated Activation of eEF-2K

Piserchio, A.; Isiroho, E. A.; Long, K.; Bohanon, A. L.; Kumar, E. A.; Will, N.; Jeruzalmi, D.; Dalby, K. N.; Ghose, R.

10.1101/2022.01.15.476372 — biochemistry — Posted on 2022-01-15

2132 Identification of a transcriptional signature found in multiple models of ASD and related disorders

Thudium, S.; Palozola, K. C.; L'Her, E.; Korb, E.

10.1101/2022.01.14.476375 — genomics — Posted on 2022-01-15

2133 Meiosis in the human pathogen Aspergillus fumigatus has the highest known number of crossovers

Auxier, B.; Becker, F.; Nijland, R.; Debets, A. J. M.; van den Heuvel, J.; Snelders, E.

10.1101/2022.01.14.476329 — genetics — Posted on 2022-01-15

2134 The salmon louse genome may be much larger than sequencing suggests

Wyngaard, G.; Skern-Mauritzen, R.; Malde, K.; Prendergast, R.; Peruzzi, S.

10.1101/2022.01.14.476287 — genetics — Posted on 2022-01-15

2135 Caenorhabditis nematodes colonize ephemeral resource patches in neotropical forests.

Sloat, S. A.; Noble, L. M.; Paaby, A. B.; Bernstein, M.; Chang, A.; Kaur, T.; Yuen, J.; Tintori, S. C.; Jackson, J. L.; Martel, A.; Salome Correa, J. A.; Stevens, L.; Blaxter, M.; Rockman, M. V.

10.1101/2022.01.13.476254 — ecology — Posted on 2022-01-15

2136 FRET monitoring of transcription factor activities in living bacteria

Wang, P.; Zhang, G.; Xu, Z.; Chen, Z.; Liu, X.; Wang, C.; Zheng, C.; Wang, J.; Zhang, H.; Yan, A.

10.1101/2022.01.14.476424 — molecular biology — Posted on 2022-01-15

2137 Modulating CRISPR-Cas genome editing using guide-complementary DNA oligonucleotides

Swartjes, T.; Shang, P.; van den Berg, D.; Kunne, T. A.; Geijsen, N.; Brouns, S. J. J.; van der Oost, J.; Staals, R.; Notebaart, R. A.

10.1101/2022.01.15.475214 — molecular biology — Posted on 2022-01-15

2138 Coupled abiotic-biotic cycling of nitrous oxide in tropical peatlands

Buessecker, S.; Sarno, A. F.; Reynolds, M. C.; Chavan, R.; Park, J.; Fontanez Ortiz, M.; Perez-Castillo, A. G.; Panduro Pisco, G.; Urquiza-Munoz, J. D.; Reis, L. P.; Ferreira-Ferreira, J.; Furtunato Maia, J. M.; Holbert, K. E.; Penton, C. R.; Hall, S. J.; Ghandi, H.; Boechat, I. G.; Guecker, B.; Ostrom, N. E.; Cadillo-Quiroz, H.

10.1101/2022.01.14.475290 — microbiology — Posted on 2022-01-15

2139 Broad-spectrum mono- and combinational drug therapies for global viral pandemic preparedness

10.1101/2022.01.15.476444 — microbiology — Posted on 2022-01-15

2140 Ovariectomy increases paclitaxel-induced mechanical hypersensitivity and reduces anti-inflammatory CD4+ T cells in the dorsal root ganglion of female mice

Goode, D. J.; Mecum, N. E.

10.1101/2022.01.13.476262 — immunology — Posted on 2022-01-15

2141 Comprehensive preclinical evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease

Jambeau, M.; Meyer, K. D.; Hruska-Plochan, M.; Tabet, R.; Lee, C.-Z.; Ray-Soni, A.; Aguilar, C.; Savage, K.; Mishra, N.; Cavegn, N.; Borter, P.; Lin, C.-C.; Jansen-West, K.; Jiang, J.; Freyermuth, F.; Li, N.; De Rossi, P.; Perez-Berlanga, M.; Jiang, X.; Daughrity, L. M.; Pereira, J.; Narayanan, S.; Gu, Y.; Dhokai, S.; Dalkilic-Liddle, I.; Maniecka, Z.; Weber, J.; Workman, M.; McAlonis-Downes, M.; Berezovski, E.; Zhang, Y.-J.; Berry, J.; Wainger, B. J.; Kankel, M. W.; Rushe, M.; Hock, C.; Nitsch, R. M.; Cleveland, D. W.; Petrucelli, L.; Gendron, T.; Montrasio, F.; Grimm, J.; Polymenidou, M.; La

10.1101/2022.01.13.475329 — neuroscience — Posted on 2022-01-15

2142 Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of Fragile X Syndrome

Javadi, S.; Li, Y.; Shen, J.; Zhao, L.; Fu, Y.; Wang, D.; Zhao, X.

10.1101/2022.01.14.476402 — neuroscience — Posted on 2022-01-15

2143 Transcranial alternating current stimulation does not modulate corticospinal activity in humans

Ibanez, J.; Zicher, B.; Brown, K.; Rocchi, L.; Casolo, A.; Del Vecchio, A.; Spampinato, D.; Vollete, C.-A.; Rothwell, J. C.; Baker, S. N.; Farina, D.

10.1101/2022.01.13.476093 — neuroscience — Posted on 2022-01-15

2144 Ehrlichia SLiM ligand mimetic activates Notch signaling in human monocytes

Patterson, L. L.; Velayutham, T. S.; Byerly, C. D.; Bui, D. C.; Patel, J.; Veljkovic, V.; Paessler, S.; McBride, J. W.

10.1101/2022.01.13.476283 — pathology — Posted on 2022-01-15

2145 Multisite Phosphorylation and Binding Alter Conformational Dynamics of the 4E-BP2 Protein

Smyth, S.; Zhang, Z.; Bah, A.; Tsangaris, T.; Dawson, J.; Forman-Kay, J. D.; Gradinaru, C.

10.1101/2022.01.14.476386 — biophysics — Posted on 2022-01-15

2146 Graphics processing unit-accelerated Monte Carlo simulation of polarized light in complex three-dimensional media

Yan, S.; Jacques, S. L.; Ramella-Roman, J. C.; Fang, Q.

10.1101/2022.01.13.476270 — biophysics — Posted on 2022-01-15

2147 Critical assessment of pan-genomics of metagenome-assembled genomes

Li, T.; Yin, Y.

10.1101/2022.01.13.476228 — bioinformatics — Posted on 2022-01-15

2148 Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance anti-HIV activity in vitro

Pan, H.; Wang, J.; Liang, H.; Jiang, Z.; Zhao, L.; Wang, Y.; Yang, X.; Liang, Z.; Shen, X.; Lin, Q.; Liang, Y.; Yang, J.; Lu, P.; Zhu, Y.; Xiang, W.; Li, M.; Wang, P.; Zhu, H.

10.1101/2022.01.14.476413 — bioengineering — Posted on 2022-01-15

2149 Mixing genome annotation methods in a comparative analysis inflates the apparent number of lineage-specific genes

Weisman, C. M.; Murray, A. M.; Eddy, S. R.

10.1101/2022.01.13.476251 — genomics — Posted on 2022-01-15

2150 An ancient truncated duplication of the anti-Mullerian hormone receptor type 2 gene is a potential conserved master sex determinant in the Pangasiidae catfish family

Wen, M.; Pan, Q.; Jouanno, E.; Montfort, J.; Zahm, M.; Cabau, C.; Klopp, C.; Iampietro, C.; Roques, C.; Bouchez, O.; Castinel, A.; Donnadieu, C.; Parrinello, H.; Poncet, C.; Belmonte, E.; Gautier, V.; Avarre, J.-C.; Dugue, R.; Gustiano, R.; Ha, T. T. t.; Campet, M.; Sriphairoj, K.; Ribolli, J.; deAlmeida, F. L.; Desvignes, T.; Postlethwait, J. H.; FloiBucao, C.; Robinson-Rechavi, M.; Bobe, J.; Herpin, A.; Guiguen, Y.

10.1101/2022.01.14.475871 — genomics — Posted on 2022-01-15

2151 Gene regulatory evolution in cold-adapted fly populations neutralizes plasticity and may undermine genetic canalization

Huang, Y.; Lack, J.; Hoppel, G.; Pool, J. E.

10.1101/2022.01.14.476421 — evolutionary biology — Posted on 2022-01-15

2152 A preliminary description of the ecological characteristics of wild waterbird Japanese encephalitis virus hosts in high risk landscapes in India

Walsh, M.; Pattanaik, A.; Vyas, N.; Saxena, D.; Webb, C.; Sawleshwarkar, S.; Mukhopadhyay, C.

10.1101/2022.01.13.476136 — ecology — Posted on 2022-01-15

Marien, j.; Vanden Broecke, B.; Tafompa, P. J.; Bernaerts, L.; Salvador, A. R.; Mnyone, L. L.; Mulungu, L.; Leirs, H.

10.1101/2022.01.14.476303 — ecology — Posted on 2022-01-15

2154 The RNA-binding landscape of HAX1 protein indicates its involvement in ribosome biogenesis and translation.

Balcarak, A.; Macech-Klicka, E.; Wakula, M.; Tomecki, R.; Goryca, K.; Rydzanicz, M.; Chmielarczyk, M.; Wisniewska, M.; Lyczek, F.; Helwak, A.; Tollervey, D.; Kudla, G.; Grzybowska, E.

10.1101/2022.01.14.476349 — molecular biology — Posted on 2022-01-15

2155 Codon optimality is the primary contributor to the exceptional mutational sensitivity of CcdA antitoxin in its operonic context

Chandra, S.; Gupta, K.; Khare, S.; Kohli, P.; Asok, A.; Mohan, S. V.; Gowda, H.; Varadarajan, R.

10.1101/2022.01.15.476443 — molecular biology — Posted on 2022-01-15

2156 EPSTEIN-BARR VIRUS LMP1 ENHANCES LEVELS OF MICROVESICLE-ASSOCIATED PD-L1

Meckes, D. G.; Harb, M. A.; Sun, L.

10.1101/2022.01.14.476429 — microbiology — Posted on 2022-01-15

2157 Dickeya colocasiae sp. nov. isolated from wetland taro, Colocasia esculentum

Boluk, G.; Dobhal, S.; Arizala, D.; Alvarez, A. M.; Arif, M.

10.1101/2022.01.14.476417 — microbiology — Posted on 2022-01-15

2158 The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence

Osman, M. M.; Shanahan, J. K.; Chu, F.; Takaki, K.; Pinckert, M.; Pagan, A. J.; Brosch, R.; Conrad, W.; Ramakrishnan, L.

10.1101/2022.01.14.476355 — microbiology — Posted on 2022-01-15

2159 CARD9 in Neutrophils Protects from Colitis and Controls Mitochondrial Metabolism and Cell Survival

Danne, C.; Michaudel, C.; Skerniskyte, J.; Planchais, J.; Magniez, A.; Agus, A.; Michel, M.-L.; Lamas, B.; Da-Costa, G.; Spatz, M.; Oeuvray, C.; Galbert, C.; Poirier, M.; Wang, Y.; Lapiere, A.; Rolhion, N.; Ledent, T.; Pionneau, C.; Chardonnet, S.; Bellvert, F.; Cahoreau, E.; Rocher, A.; Arguello, R. J.; Peyssonnaux, C.; Louis, S.; Lavie-Richard, M.; Langella, P.; El-Benna, J.; Marteyn, B.; Sokol, H.

10.1101/2022.01.14.476327 — immunology — Posted on 2022-01-15

2160 Modeling predicts differences in CAR T cell signaling due to bio-logical variability

Tserunyan, V.; Finley, S. D.

10.1101/2022.01.14.476364 — systems biology — Posted on 2022-01-15

2161 TRF2 rescues pathogenic phenotypes in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs

Eguchi, A.; Torres-Bigio, S. I.; Koleckar, K.; Birnbaum, F.; Blau, H. M.

10.1101/2022.01.10.475653 — cell biology — Posted on 2022-01-15

2162 Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern.

Vangeel, L.; Chiu, W.; De Jonghe, S.; Maes, P.; Slechten, B.; Raymenants, J.; Andre, E.; Leyssen, P.; Neyts, J.; Jochmans, D.

10.1101/2021.12.27.474275 — microbiology — Posted on 2022-01-15

2163 Dissociating the Neural Correlates of Planning and Executing Tasks with Nested Task Sets

Cookson, S. L.; Schumacher, E. H.

10.1101/2021.08.26.457791 — neuroscience — Posted on 2022-01-15

2164 Metabolomic, photoprotective, and photosynthetic acclimatory responses to post-flowering drought in sorghum

Baker, c.; Patel, D.; Cole, B. J.; Ching, L. G.; Dautermann, O.; Kelikian, A. C.; Allison, C.; Pedraza, J.; Sievert, J.; Bilbao, A.; Lee, J.-Y.; Kim, Y.-M.; Kyle, J. E.; Bloodsworth, K. J.; Paurus, V.; Hixson, K. K.; Hutmacher, R.; Dahlberg, J.; Lemaux, P.; Niyogi, K. K.

10.1101/2022.01.14.476420 — plant biology — Posted on 2022-01-15

2165 Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

Cui, Z.; Liu, P.; Wang, N.; Wang, L.; Fan, K.; Zhu, Q.; Wang, K.; Chen, R.; Feng, R.; Jia, Z.; Yang, M.; Zhu, B.; Fu, W.; Chu, T.; Feng, L.; Wang, Y.; Pei, X.; Yang, P.; Xie, X. S.; Cao, L.; Cao, Y. R.; Wang, X.

10.1101/2021.12.29.474402 — biophysics — Posted on 2022-01-15

2166 Allometric tissue-scale forces activate mechanoresponsive immune cells to drive pathological foreign body response to biomedical implants

Padmanabhan, J.; Chen, K.; Sivaraj, D.; Kuehlmann, B. A.; Bonham, C. A.; Dohi, T.; Henn, D.; Stern-Buchbinder, Z. A.; Than, P. A.; Hosseini, H. S.; Barrera, J. A.; Kussie, H. C.; Magbual, N. J.; Borrelli, M. R.; Trotsyuk, A. A.; Kwon, S. H.; Dunn, J. C. Y.; Maan, Z. N.; Januszyk, M.; Prantl, L.; Gurtner, G. C.

10.1101/2022.01.14.476395 — bioengineering — Posted on 2022-01-15

2167 Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX

Williamson, L. J.; Galchenkova, M.; Best, H. L.; Bean, R. J.; Munke, A.; Awel, S.; Pena, G.; Knoska, J.; Schubert, R.; Doerner, K.; Lloyd-Evans, E.; Young, M.; Valerio, J.; Kloos, M.; Sikorski, M.; Mills, G.; Bieleki, J.; Kirkwood, H.; Kim, C.; de Wijn, R.; Lorenzen, K.; Xavier, P. L.; Rahmani, A.; Gelisio, L.; Yefanov, O.; Mancuso, A. P.; Chapman, H. N.; Crickmore, N.; Rizkallah, P. J.; Berry, C.; Oberthur, D.

10.1101/2022.01.14.476343 — biochemistry — Posted on 2022-01-15

2168 Interactive effect matters: a combination of herbivory degree and the ratio of generalist to specialist better predicts evolution of plant defense

Pan, Y.; Pan, X.; Faria, L. D. B.; Li, B.

10.1101/2022.01.13.476260 — evolutionary biology — Posted on 2022-01-15

2169 The effect of indoor daylight spectrum and intensity on viability of indoor pathogens on different surface materials

Lam, M. I.; Vojnits, K.; Zhao, M.; Pakpour, S.; Macnaughton, P.

10.1101/2022.01.14.476401 — microbiology — Posted on 2022-01-15

2170 Phosphatidylserine within the Viral Membrane Enhances Chikungunya Virus Infectivity in a Cell-type Dependent Manner

Miazgowicz, K. L.; Reyes Ballista, J. M.; Acciani, M. D.; Jimenez, A. R.; Belloli, R. S.; Duncan, A. M.; Havranek, K. E.; Brindley, M. A.

10.1101/2022.01.14.476428 — microbiology — Posted on 2022-01-15

2171 Cross-species permissivity: structure of a goat adeno-associated virus and its complex with the human receptor, AAVR

Large, E. E.; Silveria, M. A.; White, T. A.; Chapman, M. S.

10.1101/2022.01.14.476406 — microbiology — Posted on 2022-01-15

2172 Significant organic carbon acquisition by Prochlorococcus in the oceans

Wu, Z.; Aharonovich, D.; Roth-Rosenberg, D.; Weissberg, O.; Luzzatto-Knaan, T.; Vogts, A.; Zoccarato, L.; Eigemann, F.; Grossart, H.-P.; Voss, M.; Follows, M. J.; Sher, D. J.

10.1101/2022.01.14.476346 — microbiology — Posted on 2022-01-15

2173 Metabolic switching and cell wall remodelling of Mycobacterium tuberculosis during bone tuberculosis

Kaur, K.; Sharma, S.; Abhishek, S.; Kaur, P.; Saini, U. C.; Dhillon, M. S.; Karakousis, P. C.; Verma, I.

10.1101/2022.01.13.476285 — microbiology — Posted on 2022-01-15

2174 Structural and thermodynamic analyses of the β-to-α transformation in RfaH reveal principles of fold-switching proteins

Zuber, P. K.; Daviter, T.; Heissmann, R.; Persau, U.; Schweimer, K.; Knauer, S. H.

10.1101/2022.01.14.476317 — biophysics — Posted on 2022-01-15

2175 The assembled Banana dihaploid mitochondrial genome is compact with a high number of gene copies

Prakash, S. P.; Chandrasekar, V.; Subramanian, S.; Ummar, R.

10.1101/2022.01.13.476214 — bioinformatics — Posted on 2022-01-15

2176 Improving the time and space complexity of the WFA algorithm and generalizing its scoring

Eizenga, J. M.; Paten, B.

10.1101/2022.01.12.476087 — bioinformatics — Posted on 2022-01-15

2177 Kernel Local Fisher Discriminant Analysis of Principal Components (KLFDAPC) significantly improves the accuracy of predicting geographic origin of individuals

Qin, X.; Chiang, C. W. K.; Gaggiotti, O. E.

10.1101/2021.05.15.444294 — genomics — Posted on 2022-01-15

2178 The effect of mainland dynamics on data and parameter estimates in island biogeography

Lambert, J. W.; Santos Neves, P.; Bilderbeek, R.; Valente, L.; Etienne, R. S.

10.1101/2022.01.13.476210 — evolutionary biology — Posted on 2022-01-15

2179 Combined influence of food availability and agricultural intensification on a declining aerial insectivore

Garrett, D. R.; Pelletier, F.; Garant, D.; Belisle, M.

10.1101/2021.02.02.427782 — ecology — Posted on 2022-01-15

2180 Interacting effects of cold snaps, rain, and agriculture on the fledging success of a declining aerial insectivore

Garrett, D. R.; Pelletier, F.; Garant, D.; Belisle, M.

10.1101/2021.06.29.450344 — ecology — Posted on 2022-01-15

2181 The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection

Anikeeva, N.; Steblyanko, M.; Kuri-Cervantes, L.; Buggert, M.; Betts, M. R.; Sykulev, Y.

10.1101/2022.01.13.476200 — immunology — Posted on 2022-01-15

2182 Out of the blue; Phototropins of the leaf vascular bundle sheath mediate the blue light regulation of the leaf hydraulic conductance

Grunwald, Y.; Gosa, S. C.; Torne, T.; Moran, N.; Moshelion, M.

10.1101/720912 — plant biology — Posted on 2022-01-15

2183 ROPIUS0: A deep learning-based protocol for protein structure prediction and model selection and its performance in CASP14

Margelevicius, M.

10.1101/2021.06.22.449457 — bioinformatics — Posted on 2022-01-15

2184 BitterMatch: Recommendation systems for matching molecules with bitter taste receptors

Margulis, E.; Slavutsky, Y.; Lang, T.; Behrens, M.; Benjamini, Y.; Niv, M. Y.

10.1101/2022.01.13.476205 — biochemistry — Posted on 2022-01-15

2185 Forebrain glucocorticoid receptor overexpression alters behavioral encoding of hippocampal CA1 pyramidal cells in mice

Spencer-Segal, J. L.; Gavade, S.; Wei, Q.; Johnston, C.; Kounelis, S.; Laborc, K.; Akil, H.

10.1101/2022.01.13.476185 — neuroscience — Posted on 2022-01-15

2186 Three Reagents for in-Solution Enrichment of Ancient Human DNA at More than a Million SNPs

Rohland, N.; Mallick, S.; Mah, M.; Maier, R. M.; Patterson, N. J.; Reich, D.

10.1101/2022.01.13.476259 — genomics — Posted on 2022-01-15

2187 Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3

Willemsen, N.; Arigoni, I.; Studencka-Turski, M.; Krüger, E.; Bartelt, A.

10.1101/2022.01.14.476367 — pathology — Posted on 2022-01-15

2188 Decreased cell stiffness facilitates detachment and migration of breast cancer cells in 3D collagen matrices: An exploratory study

Higgins, G.; Kim, J. E.; Ferruzzi, J.; Abdalrahman, T.; Franz, T.; Zaman, M. H.

10.1101/2021.01.21.427639 — cancer biology — Posted on 2022-01-15

2189 Mechanisms of A-type lamin targeting to nuclear ruptures are disrupted in LMNA- and BANF1- associated progerias

Sears, R. M.; Roux, K. J.

10.1101/2022.01.14.476371 — cell biology — Posted on 2022-01-15

2190 Biophysical and Architectural Mechanisms of Subthalamic Theta under Response Conflict

Moolchand, P.; Jones, S. R.; Frank, M. J.

10.1101/2021.11.10.468101 — neuroscience — Posted on 2022-01-15

2191 Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2ε in vomeronasal sensory neurons

Lin, J. M.; Mitchell, T. A.; Rothstein, M.; Pehl, A.; Taroc, E. Z. M.; Ketreddi, R. R.; Parra, K. E.; Zuloaga, D. G.; Simoes-Costa, M.; Forni, P. E.

10.1101/2022.01.14.476379 — developmental biology — Posted on 2022-01-14

2192 Syndecan Regulates Cellular Morphogenesis in Cooperation with the Netrin Guidance Pathway and Rho-family GTPases

Dima, R.; Bah Tahe, M.; Chabi, Y. A.; Rivollet, L.; Arena, A. F.; Socovich, A. M.; Shaye, D.; Benard, C. Y.

10.1101/2022.01.13.476274 — developmental biology — Posted on 2022-01-14

2193 Rab35 Governs Apicobasal Polarity Through Regulation of Actin Dynamics During Sprouting Angiogenesis

Francis, C. R.; Kincross, H.; Kushner, E. J.

10.1101/2022.01.13.476231 — developmental biology — Posted on 2022-01-14

2194 Identification and Age-dependent Increase of Platelet Biased Human Hematopoietic Stem Cells

Aksoz, M.; Gafencu, G.-A.; Stoilova, B. S.; Buono, M.; Meng, Y.; Jakobsen, N. A.; Metzner, M.; Clark, S.-A.; Beveridge, R.; Thongjuea, S.; Vyas, P.; Nerlov, C.

10.1101/2022.01.14.475546 — cell biology — Posted on 2022-01-14

2195 Caffeine and MDMA (ecstasy) exacerbate ER stress triggered by hyperthermia

Trychta, K. A.; Harvey, B. K.

10.1101/2022.01.14.476356 — cell biology — Posted on 2022-01-14

2196 Prom1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium

Hurtado Serra, C. F.; Liu, H.; Qian, J.; Mori, M.; Lu, J.; Cardoso, W. V.

10.1101/2022.01.13.475833 — cell biology — Posted on 2022-01-14

2197 dsRNA-induced condensation of antiviral proteins promotes PKR activation

Corbet, G. A.; Burke, J. M.; Bublitz, G. R.; Parker, R.

10.1101/2022.01.14.476399 — cell biology — Posted on 2022-01-14

2198 Comparative analysis of cattle breeds as satellite cells donors for cultured beef

Melzener, L.; Ding, S.; Hueber, R.; Messmer, T.; Zhou, G.; Post, M. J.; Flack, J. E.

10.1101/2022.01.14.476358 — cell biology — Posted on 2022-01-14

2199 Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics

Bhatia, S.; Kramer, M.; Russo, S.; Naik, P.; Arun, G.; Brophy, K.; Andrews, P. A.; Fan, C.; Perou, C. M.; Preall, J.; Ha, T.; Plenker, D.; Tuveson, D.; Rishi, A.; Wilkinson, J. E.; McCombie, W. R.; Kostroff, K.; Spector, D. L.

10.1101/2021.08.09.455691 — cancer biology — Posted on 2022-01-14

2200 Using antibody synergy to engineer a high potency biologic cocktail against C. difficile

Zhao, H.; Tasch, M.; Dodds, M.; Gewe, M.; Martinez, A.; Hutton, M.; Keeney, K.; Pollock, A.; Jester, B.; Khuong, N.; Zhang, M.; Brady, C.; Heinnickel, M.; Tabakh, H.; Sanjaya, N.; Cruickshank, K.; Paddock, T.; Ertel, S.; Struyvenberg, S.; Dang, J.; Shanitta, C.; Fletcher, D.; Goetsch, L.; Gamble, C.; Mileto, S.; Heselpoth, R.; Lyras, D.; Behnke, C.; Fischetti, V.; Finrow, B.; Roberts, J. M.

10.1101/2021.12.21.473715 — bioengineering — Posted on 2022-01-14

2201 FRaeppli, a multispectral imaging toolbox for cell tracing and dense tissue analysis in zebrafish

Caviglia, S.; Unterweger, I. A.; Gasiunaite, A.; Vanoosthuyse, A. E.; Cutrale, F.; Trinh, L. A.; Neuhauss, S. C. F.; Fraser, S. E.; Ober, E. A.

10.1101/2022.01.14.476353 — developmental biology — Posted on 2022-01-14

2202 Cell lineage specification during development of the anterior lateral plate mesoderm and forelimb field

Newton, A. H.; Williams, S. M.; Major, A. T.; Smith, C. A.

10.1101/2022.01.13.475748 — developmental biology — Posted on 2022-01-14

2203 GhCO and GhCRY1 accelerate floral meristem initiation in response to blue light to shorten cotton breeding

Yu, S.; li, X.; Wu, Y.; Liu, Z.; Li, Z.; Chi, H.; Wang, P.; Yan, F.; Yang, Y.; Qin, Y.; Tian, X.; Wei, H.; Wu, A.; Wang, H.; Zhang, X.

10.1101/2022.01.13.476244 — developmental biology — Posted on 2022-01-14

2204 Mitochondrial Network Configuration Influences Sarcomere and Myosin Filament Structure in Striated Muscles

Katti, P.; Hall, A. S.; Ajayi, P. T.; Kim, Y.; Willingham, T. B.; Bleck, C. K. E.; Wen, H.; Glancy, B.

10.1101/2022.01.14.476070 — cell biology — Posted on 2022-01-14

2205 Time-lapsed proteomics reveals a role for the novel protein, SNED1, in modulating ECM composition and protein folding

Lee, F.; Shao, X.; Gao, Y.; Naba, A.

10.1101/2022.01.13.476092 — cell biology — Posted on 2022-01-14

2206 Sub-communities of the vaginal ecosystem in pregnant and non-pregnant women.

Symul, L.; Jeganathan, P.; Costello, E.; France, M.; Bloom, S. M.; Ravel, J.; Kwon, D. S.; Relman, D. A.; Holmes, S. P.

10.1101/2021.12.10.471327 — microbiology — Posted on 2022-01-14

2207 Istradefylline, an adenosine A2a receptor antagonist, ameliorates neutrophilic airway inflammation and psoriasis in mice

Tokano, M.; Kawano, M.; Takagi, R.; Matsushita, S.

10.1101/2021.05.21.445220 — immunology — Posted on 2022-01-14

2208 Hippocampal ripples signal contextually-mediated episodic recall

Sakon, J. J.; Kahana, M. J.

10.1101/2021.06.07.447409 — neuroscience — Posted on 2022-01-14

2209 Natural and designed proteins inspired by extremotolerant organisms can form condensates and attenuate apoptosis in human cells

Veling, M. T.; Nguyen, D. T.; Thadani, N. N.; Oster, M. E.; Rollins, N. J.; Brock, K. P.; Bethel, N. P.; Lim, S.; Baker, D.; Way, J. C.; Marks, D. S.; Chang, R. L.; Silver, P. A.

10.1101/2021.10.01.462432 — synthetic biology — Posted on 2022-01-14

2210 Recruitment of Neuronal KCNQ2/3 Channels to Membrane Microdomains Depends on Palmitoylation of Alzheimer's Disease-Related Protein BACE1

Dai, G.

10.1101/2020.09.30.321307 — physiology — Posted on 2022-01-14

2211 Topological changes in telechelic micelles: flowers versus stars

Baulin, V.

10.1101/2021.08.13.455870 — biophysics — Posted on 2022-01-14

2212 Unraveling membrane properties at the organelle-level with LipidDyn

Scrima, S.; Tiberti, M.; Campo, A.; Corcelle-Termeau, E.; Judith, D.; Moller Foged, M.; Bundgaard Clemmensen, K. K.; Tooze, S.; Jäättelä, M.; Maeda, K.; Lambrughi, M.; Papaleo, E.

10.1101/2022.01.04.474788 — bioinformatics — Posted on 2022-01-14

2213 An Erwinia amylovora inducible promoter for improvement of apple fire blight resistance

Gaucher, M.; Righetti, L.; Aubourg, S.; Duge de Bernonville, T.; Brisset, M.-N.; Chevreau, E.; Vergne, E.

10.1101/767772 — bioengineering — Posted on 2022-01-14

2214 Scorepochs: a computer-aided scoring tool for resting-state M/EEG epochs

Fraschini, M.; La Cava, S. M.; Rodriguez, G.; vitale, a.; Demuru, M.

10.1101/2020.05.26.116434 — bioengineering — Posted on 2022-01-14

2215 Colocalized, Bidirectional Optogenetic Modulations in Freely Behaving Animals with a Wireless Dual-Color Optoelectronic Probe

Sheng, X.

10.1101/2021.06.02.446749 — bioengineering — Posted on 2022-01-14

2216 Nej1XLF interacts with Sae2CTIP to inhibit Dna2 mediated resection at DNA doublestrand break

Mojumdar, A.; Adam, N.; Cobb, J. A.

10.1101/2021.04.10.439283 — genetics — Posted on 2022-01-14

2217 Intramembrane protease SPP defines a cholesterol-regulated switch of the mevalonate pathway

Heidasch, R.; Avci, D.; Lüchtenborg, C.; Kale, D.; Beard, H.; Mentrup, T.; Barniol-Xicota, M.; Schröder, B.; verhelst, S.; Brügger, B.; Lemberg, M. K.

10.1101/2021.07.19.452877 — cell biology — Posted on 2022-01-14

2218 Pericentriolar matrix integrity relies on cenexin and Polo-Like Kinase (PLK)1

Aljiboury, A. A.; Mujcic, A.; Curtis, E.; Cammerino, T.; Magny, D.; Lan, Y.; Bates, M.; Freshour, J.; Ahmed-Braimah, Y. H.; Hehnly, H.

10.1101/2022.01.09.475500 — cell biology — Posted on 2022-01-14

2219 Activity subspaces in medial prefrontal cortex distinguish states of the world

Maggi, S.; Humphries, M. D.

10.1101/668962 — neuroscience — Posted on 2022-01-14

2220 High-titer production of aromatic amines in metabolically engineered Escherichia coli

Yang, T.; Wu, P.; Zhang, Y.; Yuan, J.

10.1101/2022.01.14.476304 — bioengineering — Posted on 2022-01-14

2221 Structures of LIG1 engaging with mutagenic mismatches inserted by polβ in base excision repair

Tang, Q.; McKenna, R.; Caglayan, M.

10.1101/2022.01.14.473406 — biochemistry — Posted on 2022-01-14

2222 Location bias contributes to functionally selective responses of biased CXCR3 agonists

Eiger, D. S.; Boldizsar, N.; Honeycutt, C. C.; Gardner, J.; Kirchner, S.; Hicks, C.; Choi, I.; Pham, U.; Zheng, K.; Warman, A.; Smith, J.; Zhang, J.; Rajagopal, S.

10.1101/2022.01.13.476255 — biochemistry — Posted on 2022-01-14

2223 Enhancement of RecET-mediated in vivo linear DNA assembly by a xonA mutation

Sawitzke, J. A.; Costantino, N. C.; Hutchinson, E.; Thomason, L.; Court, D. L.

10.1101/2022.01.13.476211 — molecular biology — Posted on 2022-01-14

2224 Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

Labib, K.; Fujisawa, R.

10.1101/2022.01.13.476277 — molecular biology — Posted on 2022-01-14

2225 Transcriptomic analysis reveals a role for the nervous system in regulating growth and development of Fasciola hepatica juveniles

Robb, E.; McCammick, E.; Wells, D.; McVeigh, P.; Gardiner, E.; Armstrong, R.; McCusker, P.; Mousley, A.; Clarke, N.; Marks, N.; Maule, A. G.

10.1101/2022.01.13.476286 — molecular biology — Posted on 2022-01-14

2226 Collagen-binding integrin alpha11beta1 contributes to joint destruction in arthritic hTNFtg mice

Deichsel, A.; Giuseppe, A.; Zeinert, I.; Rauwolf, K. K.; Lu, N.; Beckmann, D.; Krause, A.; Eckes, B.; Hansen, U.; Kronenberg, D.; Gullberg, D.; Pap, T.; Korb-Pap, A.

10.1101/2022.01.14.476301 — molecular biology — Posted on 2022-01-14

2227 Bat Red Blood Cells express Nucleic Acid Sensing Receptors and bind RNA and DNA

Lam, L. M.; Dobkin, J.; Eckart, K. A.; Gereg, I.; DiSalvo, A.; Nolder, A.; Anis, E.; Ellis, J. C.; Turner, G.; Mangalmurti, N. S.

10.1101/2022.01.13.476238 — immunology — Posted on 2022-01-14

2228 A Four-Step Enzymatic Cascade for Efficient Production of L-Phenylglycine from Biobased L-Phenylalanine

Zhu, Y.; Yuan, J.

10.1101/2022.01.14.476296 — synthetic biology — Posted on 2022-01-14

2229 Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation

Li, J.; Jamieson, W. D.; Dimitriou, P.; Xu, W.; Rohde, P.; Martinac, B.; Baker, M. A.; Drinkwater, B.; Castell, O.; Barrow, D.

10.1101/2022.01.13.476178 — synthetic biology — Posted on 2022-01-14

2230 The role of LHCBM1 in non-photochemical quenching in Chlamydomonas reinhardtii

Liu, X.; Nawrocki, W. J.; Croce, R.

10.1101/2022.01.13.476201 — plant biology — Posted on 2022-01-14

2231 Inflammatory signals from fatty bone marrow supports the early stages of DNMT3a driven clonal hematopoiesis

Zioni, N.; Bercovich, A.; Chapal-Ilani, N.; Solomon, A.; Petrovich, E.; .Sacma, M.; Geiger, H.; Scheller, M.; Müller-Tidow, C.; Lipka, D.; Shlush, E.; Minden, M.; Kaushansky, N.; Shlush, L.

10.1101/2022.01.13.476218 — cancer biology — Posted on 2022-01-14

2232 Characterizing the conformational free-energy landscape of RNA using single-molecule field-effect transistors

Jang, S. S.; Dubnik, S.; Hon, J.; Nuckolls, C.; Gonzalez, R. L.

10.1101/2022.01.13.475405 — biophysics — Posted on 2022-01-14

2233 Probabilistic modeling of ambient noise in single-cell omics data

Sheng, C.; Lopes, R.; Li, G.; Schuierer, S.; Waldt, A.; Cuttat, R.; Dimitrieva, S.; Kauffmann, A.; Durand, E.; Galli, G. G.; Roma, G.; de Weck, A.

10.1101/2022.01.14.476312 — bioinformatics — Posted on 2022-01-14

2234 ATP6V1B2 and IFI27 and their intrinsic functional genomic characteristics associated with SARS-CoV-2

Zhang, Z.

10.1101/2022.01.13.476223 — bioinformatics — Posted on 2022-01-14

2235 SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding

Brian, B. F.; Sjaastad, F. V.; Freedman, T. S.

10.1101/2022.01.13.475555 — biochemistry — Posted on 2022-01-14

2236 X-linked intellectual disability mutations alter the conformational state of a histone demethylase's sensing of chromatin

Ugur, F. S.; Kelly, M. J. S.; Galonic Fujimori, D.

10.1101/2022.01.13.476263 — biochemistry — Posted on 2022-01-14

2237 Activated MST2 kinase is free of kinetic regulation

Koehler, T. J.; Tran, T.; Kavran, J. M.

10.1101/2022.01.13.476221 — biochemistry — Posted on 2022-01-14

2238 Covariance predicts conserved protein residue interactions important to the emergence and continued evolution of SARS-CoV-2 as a human pathogen

Robins, W. P.; Mekalanos, J. J.

10.1101/2022.01.13.476204 — microbiology — Posted on 2022-01-14

2239 DNA methylation meta-analysis confirms the division of the genome into two functional groups

Salnikov, L.; Goldberg, S.; Sukumaran, P.; Pinsky, E.

10.1101/2022.01.10.475724 — developmental biology — Posted on 2022-01-14

2240 Impact of altering gut microbiota metabolism on osteomyelitis severity in obesity-related type 2 diabetes

Bui, T. I.; Gill, A. L.; Mooney, R. A.; Gill, S. R.

10.1101/2022.01.13.476282 — microbiology — Posted on 2022-01-14

2241 The C-terminal domain of SEC-10 is fundamental for exocyst function, Spitzenkorper organization and cell morphogenesis in Neurospora crassa.

Figueroa-Melendez, A.; Martinez-Nunez, L.; Rico-Ramirez, A. M.; Martinez-Andrade, J. M.; Munson, M.; Riquelme, M.

10.1101/2022.01.14.475644 — microbiology — Posted on 2022-01-14

2242 Bulk and spatially resolved extracellular metabolomics of free-living nitrogen fixation

Smercina, D.; Kim, Y.-M.; Lipton, M.; Velickovic, D.; Hofmockel, K.

10.1101/2022.01.13.476280 — microbiology — Posted on 2022-01-14

2243 The bladder microbiome, metabolome, cytokines, and phenotypes in patients with systemic lupus erythematosus

Liu, F.; Du, J.; Zhai, Q.; Hu, J.; Miller, A. W.; Ren, T.; Feng, Y.; Jiang, P.; Hu, L.; Sheng, J.; Gu, C.; Yan, R.; Lv, L.; Wolfe, A. J.; Feng, N.

10.1101/2022.01.13.476281 — microbiology — Posted on 2022-01-14

2244 The RNA polymerase gene specificity factor sigma 54 is required for homogeneous non-planktonic growth of uropathogenic Escherichia coli

Switzer, A.; Burchell, L.; Mitsidis, P.; Wigneshweraraj, R.

10.1101/2022.01.13.476216 — microbiology — Posted on 2022-01-14

2245 Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

Mould, D. L.; Stevanovic, M.; Ashare, A.; Schultz, D.; Hogan, D.

10.1101/2022.01.14.476307 — microbiology — Posted on 2022-01-14

2246 Speeded detection of spectrotemporal modulations of sound

Veugen, L. C. E.; Van Opstal, A. J.; van Wanrooij, M. M.

10.1101/2022.01.13.476175 — neuroscience — Posted on 2022-01-14

2247 Increased insula activity precedes the formation of subjective Gestalt

Wilding, M.; Koerner, C.; Ischebeck, A.; Zaretskaya, N.

10.1101/2022.01.13.476145 — neuroscience — Posted on 2022-01-14

2248 No One Is Leaving This Time: Appraisal of Awareness and Knowledge of Port Health Officers on International Health Regulation IHR (2005)

Adiama, Y. B.; Adewoy, S. O.; Olaniyi, O. A.; Habeeb, L. M.; Ahmed, A.; Raimi, M. O.

10.1101/2022.01.12.476011 — scientific communication and education — Posted on 2022-01-14

2249 MS1Connect: a mass spectrometry run similarity measure

Lin, A.; Kaiser, B. L. D.; Hutchison, J. R.; Bilmes, J. A.; Noble, W. S.

10.1101/2022.01.12.476125 — bioinformatics — Posted on 2022-01-14

2250 Multi-omic data helps improve prediction of personalised tumor suppressors and oncogenes

Sudhakar, M.; Rengaswamy, R.; Raman, K.

10.1101/2022.01.13.476163 — bioinformatics — Posted on 2022-01-14

2251 MIA: An Open Source Standalone Deep Learning Application for Microscopic Image Analysis

Koerber, N.

10.1101/2022.01.14.476308 — bioinformatics — Posted on 2022-01-14

2252 Automated bioprocess feedback operation in a high throughput facility via the integration of a mobile robotic lab assistant

Kaspersetz, L.; Waldburger, S.; Schermeyer, M.- T.; Riedel, S. L.; Gross, S.; Neubauer, P.; Cruz-Bournazou, M.- N.

10.1101/2022.01.13.476044 — bioengineering — Posted on 2022-01-14

2253 Fiber-parenchyma trade-off underlies changes in tropical forest structure and xylem architecture across a soil water gradient

Lourenco, J.; Bittencourt, P. R. d. L.; Enquist, B. J.; von Arx, G.; Morino, K.; Thomaz, L. D.; Rowland, L.

10.1101/2022.01.13.476164 — ecology — Posted on 2022-01-14

2254 Utilizing citizen science to model the distribution of Aedes aegypti in West Africa

Freeman, E. A.; Carlton, E. J.; Paull, S.; Dadzie, S.; Buchwald, A.

10.1101/2022.01.14.476313 — ecology — Posted on 2022-01-14

2255 Phenology effects on productivity and hatching-asynchrony of American kestrels (Falco sparverius) across a continent

Callery, K. R.; Schulwitz, S. E.; Hunt, A. R.; Winiarski, J. M.; McClure, C. J. W.; Fischer, R. A.; Heath, J. A.

10.1101/2022.01.14.476385 — ecology — Posted on 2022-01-14

2256 Imaging with spatio-temporal modelling to characterize the dynamics of plant-pathogen lesions

Leclerc, M.; Jumel, S.; Hamelin, F. M.; Treilhaud, R.; Parisey, N.; Mammeri, Y.

10.1101/2022.01.13.476165 — ecology — Posted on 2022-01-14

2257 Non-target effects of ten essential oils on the egg-parasitoid Trichogramma evanescens

van Oudenhove, L.; Cazier, A.; Fillaud, M.; Lavoir, A.-V.; Fatnassi, H.; Perez, G.; Calcagno, V.

10.1101/2022.01.14.476310 — ecology — Posted on 2022-01-14

2258 An essential function for autocrine Hedgehog signaling in epithelial proliferation and differentiation in the trachea

Yin, W.; Liontos, A.; Koepke, J.; Ghoul, M.; Mazzocchi, L.; Liu, X.; Lu, C.; Wu, H.; Fysikopoulos, A.; Sountoulidis, A.; Seeger, W.; Ruppert, C.; Gunther, A.; Stainier, D. Y. R.; Samakovlis, C.

10.1101/2022.01.13.476169 — developmental biology — Posted on 2022-01-14

2259 Origin of congenital coronary arterio-ventricular fistulae from anomalous epicardial and myocardial development

Palmquist-Gomes, P.; Ruiz-Villalba, A.; Guadix, J. A.; Romero, J. P.; Bessieres, B.; MacGrogan, D.; Conejo-Munoz, L.; Ortiz-Garrido, A.; Picazo, B.; Houyel, L.; Gomez-Cabrero, D.; Meilhac, S.; De la Pompa, J. L.; Perez-Pomares, J. M.

10.1101/2022.01.13.476153 — developmental biology — Posted on 2022-01-14

2260 Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice

Mojumdar, A.; Adam, N.; Cobb, J. A.

10.1101/2022.01.13.476264 — molecular biology — Posted on 2022-01-14

2261 CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway

Gomez-Cabello, D.; Pappas, G.; Aguilar-Morante, D.; Dinant, C.; Bartek, J.

10.1101/2022.01.14.476291 — molecular biology — Posted on 2022-01-14

2262 The AAA+ ATPase RavA-ViaA complex sensitizes Escherichia coli to aminoglycosides under anaerobic low energy conservation conditions

El Khoury, J.; Zamarreno, J.; Huguenot, A.; Py, B.; Barras, F.

10.1101/2022.01.13.476284 — microbiology — Posted on 2022-01-14

2263 Chlorpyrifos degradation by combined solar photo-Fenton and bacterial metabolism and simultaneous toxicity analysis in zebrafish (Danio rerio)

Nayak, T.; Ghosh, A.; Das, S.; Adhya, T. K.; Patel, P.; Mohanty, S.; Umar, M.; Das, B.; Tripathy, S. K.; Raina, V.

10.1101/2022.01.13.476273 — microbiology — Posted on 2022-01-14

2264 The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion

Introini, V.; Marin-Menendez, A.; Nettesheim, G.; Lin, Y.-C.; Kariuki, S. N.; Smith, A. L.; Jean, L.; Brewin, J. N.; Rees, D. C.; Cicuta, P.; Rayner, J. C.; Penman, B. S.

10.1101/2022.01.13.476158 — microbiology — Posted on 2022-01-14

2265 Environmental factors shape the culturable bacterial diversity in deep-sea water and surface sediments from the Mariana Trench

MA, Y.; DING, W.; WANG, Y.; CHEN, P.; ZHOU, H.; LI, X.; HUANG, Y.; NAN, P.

10.1101/2022.01.13.476188 — microbiology — Posted on 2022-01-14

2266 The interactome of Cryptococcus neoformans Rmt5 reveals multiple regulatory points in fungal cell biology and pathogenesis

Kalem, M. C.; Subbiah, H.; Shen, S.; Chen, R.; Terry, L.; Sun, Y.; Qu, J.; Panepinto, J. C.

10.1101/2022.01.13.475903 — microbiology — Posted on 2022-01-14

2267 RefZ and Noc act synthetically to prevent aberrant divisions during Bacillus subtilis sporulation

Miller, A. K.; Herman, J. K.

10.1101/2022.01.13.476237 — microbiology — Posted on 2022-01-14

2268 Expressing the pro-apoptotic Reaper protein via insertion into the structural open reading frame of Sindbis virus reduces the ability to infect Aedes aegypti mosquitoes

Carpenter, A.; Clem, R. J.

10.1101/2022.01.13.476239 — microbiology — Posted on 2022-01-14

2269 LiCl-induced sickness modulates spontaneous activity and response dynamics in rat gustatory cortex.

Stone, B. T.; Lin, J.-Y.; Mahmood, A.; Sanford, A. J.; Katz, D.

10.1101/2022.01.13.476147 — neuroscience — Posted on 2022-01-14

2270 Contextual associations represented both in neural networks and human behavior

Aminoff, E. M.; Baror, S.; Roginek, E. W.; Leeds, D. D.

10.1101/2022.01.13.476195 — neuroscience — Posted on 2022-01-14

2271 Nicotinic signaling is required for motor learning but not rehabilitation after spinal cord injury

Li, Y.; Hollis, E.

10.1101/2022.01.13.476174 — neuroscience — Posted on 2022-01-14

2272 Functional resilience of mutually repressing motifs embedded in larger regulatory networks

Harlapur, P.; Duddu, A. S.; Hari, K.; Jolly, M. K.

10.1101/2022.01.13.475824 — systems biology — Posted on 2022-01-14

2273 coveR: An R package for processing Digital Cover Photography images to retrieve forest canopy attributes

Chianucci, F.; Ferrara, C.; Puletti, N.

10.1101/2022.01.13.475850 — plant biology — Posted on 2022-01-14

2274 Glucose-stimulated calcium dynamics in beta cells from C57BL/6J, C57BL/6N, and NMRI mice: A systematic comparison of activation, activity, and deactivation properties in tissue slices

Pohorec, V.; Krizancic Bombek, L.; Skelin Klemen, M.; Dolensek, J.; Stozer, A.

10.1101/2022.01.14.476318 — physiology — Posted on 2022-01-14

2275 DeepGOZero: Improving protein function prediction from sequence and zero-shot learning based on ontology axioms

Kulmanov, M.; Hoehndorf, R.

10.1101/2022.01.14.476325 — bioinformatics — Posted on 2022-01-14

2276 A semi-supervised Bayesian mixture modelling approach for joint batch correction and classification

Coleman, S.; Castro Dopico, X.; Karlsson Hedestam, G. B.; Kirk, P. D.; Wallace, C.

10.1101/2022.01.14.476352 — bioinformatics — Posted on 2022-01-14

2277 In vitro Kinase-to-Phosphosite database (iKiP-DB) predicts kinase activity in phosphoproteomic datasets

Mari, T.; Moesbauer, K.; Wyler, E.; Landthaler, M.; Drosten, C.; Selbach, M.

10.1101/2022.01.13.476159 — bioinformatics — Posted on 2022-01-14

2278 Griottes: a generalist tool for network generation from segmented tissue images

Ronteix, G.; Bonnet, V.; Sart, S.; Sobel, J.; Esposito, E.; Baroud, C.

10.1101/2022.01.14.476345 — bioinformatics — Posted on 2022-01-14

2279 CCPLS reveals cell-type-specific spatial dependence of transcriptomes in single cells

Tsuchiya, T.; Hori, H.; Ozaki, H.

10.1101/2022.01.12.476034 — bioinformatics — Posted on 2022-01-14

2280 Integrative analysis of relative abundance data and presence-absence data of the microbiome using the LDM

Zhu, Z.; Satten, G. A.; Hu, Y.-J.

10.1101/2022.01.14.476390 — bioinformatics — Posted on 2022-01-14

2281 BlenderPhotonics - a versatile environment for 3-D complex bio-tissue modeling and light transport simulations based on Blender

Zhang, Y.; Fang, Q.

10.1101/2022.01.12.476124 — bioengineering — Posted on 2022-01-14

2282 The blowfly Chrysomya latifrons inhabits fragmented rainforests, but lacks genetic diversity and population structure

Butterworth, N. J.; Wallman, J. F.; Johnston, N. P.; Dawson, B. M.; McGaughran, A.

10.1101/2022.01.12.476129 — ecology — Posted on 2022-01-14

2283 Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia

Hom, J.; Karnavas, T.; Hartman, E.; Papoin, J.; Tang, Y.; Dulmovits, B. M.; Khan, M.; Patel, H.; Bondy, J.; Edelman, M.; Touraine, R.; Chanoz-Poulard, G.; Ottenberg, G.; Maynard, R.; Adams, D. J.; Robledo, R. F.; Grande, D. A.; Marambaud, P.; Barnes, B. J.; Durand, S.; Narla, A.; Ellis, S.; Zon, L. I.; Peters, L. L.; Costa, L. d.; Lipton, J. M.; Ackert-Bicknell, C.; Blanc, L.

10.1101/2022.01.14.476336 — cell biology — Posted on 2022-01-14

2284 White Matter Brain Structure Predicts Language Performance and Learning Success

Sanchez, S. M.; Schmidt, H.; Gallardo, G.; Anwander, A.; Brauer, J.; Friederici, A. D.; Knoesche, T.

10.1101/2022.01.14.476338 — neuroscience — Posted on 2022-01-14

2285 Using intracerebral microdialysis to probe the efficacy of repurposed drugs in Alzheimer's disease pathology

Bjorkli, C.; Hemler, M.; Julian, J.; Sandvig, A.; Sandvig, I.

10.1101/2022.01.14.476357 — neuroscience — Posted on 2022-01-14

2286 Harmonized-Multinational qEEG Norms (HarMNqEEG)

Li, M.; Wang, Y.; Lopez-Naranjo, C.; Abd Hamid, A. I.; Evans, A. C.; Savostyanov, A. N.; Calzada-Reyes, A.; Areces-Gonzalez, A.; Villringer, A.; Tobon-Quintero, C. A.; Garcia-Agustin, D.; Paz-Linares, D.; Yao, D.; Dong, L.; Aubert-Vazquez, E.; Reza, F.; Omar, H.; Abdullah, J. M.; Galler, J. R.; Ochoa-Gomez, J. F.; Prichep, L. S.; Galan-Garcia, L.; Morales-Chacon, L.; Valdes-Sosa, M. J.; Trondle, M.; Mohd Zulkifly, M. F. B.; Abdul Rahman, M. R. B.; Milakhina, N. S.; Langer, N.; Rudych, P.; Hu, S.; Koenig, T.; Virues-Alba, T. A.; Lei, X.; Bringas-Vega, M. L.; Bosch-Bayard, J. F.; Valdes-Sosa, P.

10.1101/2022.01.12.476128 — neuroscience — Posted on 2022-01-14

2287 Impaired functional connectivity of the hippocampus in murine models of NMDA-receptor antibody associated pathology

Kuchling, J.; Jurek, B.; Kents, M.; Kreye, J.; Geis, C.; Wickel, J.; Mueller, S.; Koch, S. P.; Boehm-Sturm, P.; Pruess, H.; Finke, C.

10.1101/2022.01.12.476037 — neuroscience — Posted on 2022-01-14

2288 Deciphering the evolution of microbial interactions: in silico studies of two-member microbial communities

Sambamoorthy, G.; Raman, K.

10.1101/2022.01.14.476316 — systems biology — Posted on 2022-01-14

2289 Interaction between photoperiod and variation in circadian rhythms in tomato

Xiang, Y.; Sapir, T.; Rouillard, P.; Ferrand, M.; Jimenez-Gomez, J. M.

10.1101/2022.01.14.476322 — plant biology — Posted on 2022-01-14

2290 Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development

Playfoot, C. J.; Sheppard, S.; Planet, E.; Trono, D.

10.1101/2022.01.14.476326 — genomics — Posted on 2022-01-14

2291 Parallel molecular mechanisms underlie convergent evolution of the exaggerated snout phenotype in East African cichlids

Duenser, A.; Singh, P.; Lecaudey, L. A.; Sturmbauer, C.; Albertson, C.; Gessl, W.; Pashay Ahi, E.

10.1101/2022.01.13.476207 — evolutionary biology — Posted on 2022-01-14

2292 Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit

Bilash, O. M.; Chavlis, S.; Poirazi, P.; Basu, J.

10.1101/2022.01.13.476247 — neuroscience — Posted on 2022-01-14

2293 qEEG Analysis in the Diagnosis of Alzheimers Disease; a Comparison of Functional Connectivity and Spectral Analysis

Frangopoulou, M. S.; Alimardani, M.

10.1101/2022.01.10.475756 — neuroscience — Posted on 2022-01-14

2294 The genomic basis of host and vector specificity in non-pathogenic trypanosomatids

Oldrieve, G.; Malacart, B.; Lopez-Vidal, J.; Matthews, K.

10.1101/2022.01.05.475049 — genomics — Posted on 2022-01-14

2295 APOE ε4 effects on hippocampal atrophy in the healthy elderly reflect future cognitive decline

Zhang, L.; Calero, M.; Medina, M.; Strange, B.

10.1101/2022.01.07.475319 — neuroscience — Posted on 2022-01-14

2296 Eurasian lynx populations in Western Europe: What prospects for the next 50 years?

Bauduin, S.; Germain, E.; Zimmermann, F.; Idelberger, S.; Herdtfelder, M.; Heurich, M.; Kramer-Schadt, S.; Duchamp, C.; Drouet-Hoguet, N.; Morand, A.; Blanc, L.; Charbonnel, A.; Gimenez, O.

10.1101/2021.10.22.465393 — ecology — Posted on 2022-01-14

2297 Dynamical processing of orientation precision in the primary visual cortex

Ladret, H. J.; Cortes, N.; Ikan, L.; Chavane, F.; Casanova, C.; Perrinet, L. U.

10.1101/2021.03.30.437692 — neuroscience — Posted on 2022-01-14

2298 Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus

Al-Amin, M. M.; Sullivan, R. K. P.; Alexander, S.; Carter, D. A.; Bradford, D.; Burne, T.

10.1101/2022.01.12.476116 — animal behavior and cognition — Posted on 2022-01-14

2299 PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS summary statistics

von Berg, J.; ten Dam, M.; van der Laan, S. W.; de Ridder, J.

10.1101/2022.01.14.476302 — genetics — Posted on 2022-01-14

2300 Fast event-related mapping of fingertip population receptive fields in human somatosensory and motor cortex at 7T

Khalife, S.; Francis, S. T.; Schluppeck, D.; Sanchez-Panchuelo, R.-M.; Besle, J.

10.1101/2022.01.06.471906 — neuroscience — Posted on 2022-01-14

2301 m6A-TSHub: unveiling the context-specific m6A methylation and m6A-affecting mutations in 23 human tissues

Song, B.; Huang, D.; Zhang, Y.; Wei, Z.; Su, J.; Magalhaes, J. P. d.; Rigden, D.; Meng, J.; Chen, K.

10.1101/2022.01.12.476117 — bioinformatics — Posted on 2022-01-14

2302 Single cell mutant selection for metabolic engineering of actinomycetes

Akhgari, A.; Baral, B.; Koroleva, A.; Siitonen, V.; Fewer, D. P.; Melancon, C. E.; Rahkila, J.; Metsa-Ketela, M.

10.1101/2022.01.13.476137 — bioengineering — Posted on 2022-01-14

2303 Neural ADMIXTURE: rapid population clustering with autoencoders

Mantes, A. D.; Montserrat, D. M.; Bustamante, C.; Giro-i-Nieto, X.; Ioannidis, A. G.

10.1101/2021.06.27.450081 — genomics — Posted on 2022-01-14

2304 ACDC: Analysis of Congruent Diversification Classes

Hoehna, S.; Kopperud, B. T.; Magee, A. F.

10.1101/2022.01.12.476142 — evolutionary biology — Posted on 2022-01-14

2305 Rat leukocyte population dynamics predicts a window for intervention in aging.

Beerman, I.; Yanai, H.; Dunn, C.; Park, B.; Coletta, C.; McDevitt, R.; McNeely, T.; Leone, M.; Wersto, R. P.; Perdue, K.

10.1101/2022.01.12.476126 — evolutionary biology — Posted on 2022-01-14

2306 Seasonality and competition select for variable germination behavior in perennials

ten Brink, H.; Haaland, T. R.; Opedal, O. H.

10.1101/2022.01.13.476161 — evolutionary biology — Posted on 2022-01-14

2307 Temperature-dependent genetics of thermotolerance between yeast species

Abrams, M. B.; Brem, R. B.

10.1101/2022.01.11.475859 — evolutionary biology — Posted on 2022-01-14

2308 A unified view of LCRs across species

Lee, B.; Jaberi-Lashkari, N.; Calo, E.

10.1101/2022.01.06.475253 — cell biology — Posted on 2022-01-14

2309 Leading edge stability in motile cells is an emergent property of branched actin network growth

Garner, R. M.; Theriot, J. A.

10.1101/2020.08.22.262907 — cell biology — Posted on 2022-01-14

2310 Staphylococcus aureus does not synthesize arginine from proline under physiological conditions

Bae, T.; Jeong, B.; Shah, M. A.; Roh, E.; Kim, K. K.; Park, I.

10.1101/2022.01.12.476138 — microbiology — Posted on 2022-01-14

2311 In vivo growth of Staphylococcus lugdunensis is facilitated by the concerted function of heme and non-heme iron acquisition mechanisms

Flannagan, R. S.; Brozyna, J. R.; Kumar, B.; Adolf, L. A.; Power, J. J.; Heilbronner, S.; Heinrichs, D. E.

10.1101/2022.01.12.476141 — microbiology — Posted on 2022-01-14

2312 Quantitative Restoration of Immune Defense in Old Animals Determined by Naive Antigen-Specific CD8 T cell Numbers

Uhrlaub, J.; Jergovic, M.; Bradshaw, C. M.; Sonar, S.; Coplen, C. P.; Dudakov, J.; Murray, K. O.; Lanteri, M. C.; Busch, M. P.; van den Brink, M. R. M.; Nikolich-Zugich, J.

10.1101/2021.08.09.453882 — immunology — Posted on 2022-01-14

2313 SLDP and LIPA mediate lipid droplet-plasma membrane tethering in Arabidopsis thaliana

Krawczyk, H. E.; Sun, S.; Doner, N.; Yan, Q.; Lim, M. S. S.; Scholz, P.; Niemeyer, P. W.; Schmitt, K.; Valerius, O.; Pleskot, R.; Hillmer, S.; Braus, G.; Wiermer, M.; Mullen, R. T.; Ischebeck, T.

10.1101/2022.01.13.476213 — plant biology — Posted on 2022-01-14

2314 OCT4 interprets and enhances nucleosome flexibility

MacCarthy, C.; Huertas, J.; Ortmeier, C.; vom Bruch, H.; Reinke, D.; Sander, A.; Bergbrede, T.; Schoeler, H.; Cojocaru, V.

10.1101/2021.04.27.441583 — biophysics — Posted on 2022-01-14

2315 Role of Sugar Stereochemistry on Structural and Free Energy Landscape of Double-Stranded Nucleic Acids

Kumar, A.; Singh, R. K.; Tagad, A.; Patwari, G. N.

10.1101/2020.08.15.252643 — biophysics — Posted on 2022-01-14

2316 Orientation dependent proton transverse relaxation in the human brain white matter: The magic angle effect on a cylindrical helix

Pang, Y.

10.1101/2021.09.13.460097 — biophysics — Posted on 2022-01-14

2317 Debiasing FracMinHash and deriving confidence intervals for mutation rates across a wide range of evolutionary distances

Rahman Hera, M.; Pierce-Ward, N. T.; Koslicki, D.

10.1101/2022.01.11.475870 — bioinformatics — Posted on 2022-01-14

2318 Detecting DNA of novel fungal pathogens using ResNets and a curated fungi-hosts data collection

Bartoszewicz, J. M.; Nasri, F.; Nowicka, M.; Renard, B. Y.

10.1101/2021.11.30.470625 — bioinformatics — Posted on 2022-01-14

2319 Compartmentalized Cell Envelope Biosynthesis in Mycobacterium tuberculosis

Puffal, J.; Sparks, I. L.; Brenner, J. R.; Li, X.; Leszyk, J. D.; Hayashi, J.; Shaffer, S. A.; Morita, Y. S.

10.1101/2022.01.07.475471 — microbiology — Posted on 2022-01-14

2320 Abiotic treatment to common bean plants results in an altered seed microbiome.

Bintarti, A. F.; Kearns, P. J.; Sulesky-Grieb, A.; Shade, A.

10.1101/2020.06.05.134445 — microbiology — Posted on 2022-01-14

2321 Cerebellar GABA change during visuomotor adaptation relates to adaptation performance and cerebellar network connectivity: A Magnetic Resonance Spectroscopic Imaging study.

Nettekoven, C. R.; Mitchell, L.; Clarke, W. T.; Emir, U.; Campbell, J.; Johansen-Berg, H.; Jenkinson, N.; Stagg, C. J.

10.1101/2021.12.19.473367 — neuroscience — Posted on 2022-01-14

2322 Neural harmonics of syntactic structure

Tavano, A.; Blohm, S.; Knoop, C.; Muralikrishnan, R.; Fink, L. K.; Scharinger, M.; Wagner, V.; Thiele, D.; Ghitza, O.; Ding, N.; Menninghaus, W.; Poeppel, D.

10.1101/2020.04.08.031575 — neuroscience — Posted on 2022-01-14

2323 Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction

Duttke, S.; Montilla-Perez, P.; Chang, M. W.; Li, H.; Chen, H.; Carrette, L. L. G.; de Guglielmo, G.; George, O.; Palmer, A. A.; Benner, C.; Telese, F.

10.1101/2022.01.12.475507 — neuroscience — Posted on 2022-01-14

2324 Intramolecular 13C signals inform about carbon allocation in plants

Wieloch, T.; Sharkey, T. D.; Werner, R. A.; Schleucher, J.

10.1101/2021.06.25.449710 — plant biology — Posted on 2022-01-14

2325 Structure of the Shaker Kv channel and mechanism of slow C-type inactivation

Tan, X.-F.; Bae, C.; Stix, R.; Fernandez-Marino, A. I.; Huffer, K.; Chang, T.-H.; Jiang, J.; Faraldo-Gomez, J.; Swartz, K. J.

10.1101/2021.09.21.461258 — biophysics — Posted on 2022-01-14

2326 ProtFinder: finding subcellular locations of proteins using protein interaction networks

Grover, A.; Gatto, L.

10.1101/2022.01.11.475836 — bioinformatics — Posted on 2022-01-14

2327 Analysis of genetic dominance in the UK Biobank

Palmer, D. S.; Zhou, W.; Abbott, L.; Baya, N.; Churchhouse, C.; Seed, C.; Poterba, T.; King, D.; Kanai, M.; Bloemendal, A.; Neale, B. M.

10.1101/2021.08.15.456387 — genetics — Posted on 2022-01-14

2328 Repeated truncation of a modular antimicrobial peptide gene for neural context

Hanson, M. A.; Lemaitre, B.

10.1101/2021.02.24.432738 — evolutionary biology — Posted on 2022-01-14

2329 Density dependent interactions during growth mask the effect of interactions during flowering in pollinator-sharing annual plants

James, A. R. M.; Geber, M. A.

10.1101/2021.03.31.437969 — ecology — Posted on 2022-01-14

2330 Progenitor cell integration into a barrier epithelium during adult organ turnover

Moreno-Roman, P.; Su, Y.-H.; Galenza, A.; Acosta-Alvarez, L.; Debec, A.; Guichet, A.; Knapp, J.-M.; Kizilyaprak, C.; Humbel, B. M.; Kolotuev, I.; O'Brien, L. E.

10.1101/2021.09.19.457819 — developmental biology — Posted on 2022-01-14

2331 Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS production

Alan, P.; Vandevoorde, K. R.; Joshi, B.; Cardoen, B.; Gao, G.; Mohammadzadeh, Y.; Hamarneh, G.; Nabi, I. R.

10.1101/2021.09.17.460825 — cell biology — Posted on 2022-01-14

2332 Cholesterol biosynthetic pathway induces cellular senescence through ERRa

Ziegler, D. V.; Vernier, M.; Czarnecka-Herok, J.; Scholtes, C.; Machon, C.; Guitton, J.; Rieusset, J.; Giguere, V.; Martin, N.; Bernard, D.

10.1101/2021.10.20.465100 — cell biology — Posted on 2022-01-14

2333 Centriole-independent centrosome assembly in interphase mammalian cells

Chen, F.; Wu, J.; Iwanski, M. K.; Jurriens, D.; Sandron, A.; Pasolli, M.; Puma, G.; Kromhout, J. Z.; Yang, C.; Nijenhuis, W.; Kapitein, L. C.; Akhmanova, A.

10.1101/2021.08.22.457259 — cell biology — Posted on 2022-01-14

2334 Optimized Multicolour Immunofluorescence Panel for Cattle T Cell Phenotyping by an 8-Colour, 10-Parameter Panel

Roos, E. O.; Mwangi, W.; Gerner, W.; Waters, R.; Hammond, J. A.

10.1101/2022.01.12.476027 — immunology — Posted on 2022-01-14

2335 Involvement of prelimbic cortex neurons and related circuits in the acquisition of cooperative learning by pairs of rats

Conde-Moro, A. R.; Rocha-Almeida, F.; Gebara, E.; Delgado-Garcia, J. M.; Sandi, C.; Gruart, A.

10.1101/2022.01.13.476162 — neuroscience — Posted on 2022-01-13

2336 Absence of postsynaptic activity on developing neurons alters gene expression profiles without preventing the refinement of inputs

Chong, Y.; Cooper, E.

10.1101/2020.10.21.349142 — neuroscience — Posted on 2022-01-14

2337 Distinct generation of subjective vividness and confidence during naturalistic memory retrieval in angular gyrus

Zou, F.; Kwok, S. C.

10.1101/2021.03.10.434526 — neuroscience — Posted on 2022-01-14

2338 Identifying Behavioral Structure from Deep Variational Embeddings of Animal Motion

Luxem, K.; Mocellin, P.; Fuhrmann, F.; Kuersch, J.; Remy, S.; Bauer, P.

10.1101/2020.05.14.095430 — neuroscience — Posted on 2022-01-14

2339 Bioluminescent Genetically Encoded Glutamate Indicator for Molecular Imaging of Neuronal Activity

Petersen, E. D.; Lapan, A. P.; Fillion, A. J.; Crespo, E. L.; Lambert, G. G.; Zanca, A. T.; Orcutt, R.; Hochgeschwender, U.; Shaner, N. C.; Gilad, A.

10.1101/2021.06.16.448690 — neuroscience — Posted on 2022-01-14

2340 Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina

Driedonks, T.; Jiang, L.; Carlson, B.; Han, Z.; Liu, G.; Queen, S. E.; Shirk, E. N.; Gololobova, O.; Nyberg, L. H.; Lima, G.; Paniushkina, L.; Garcia-Contreras, M.; Schonvisky, K.; Stover, M.; Guerrero-Martin, S.; Richardson, M. R.; Smith, B.; Mahairaki, V.; Lai, C. P.; Izzi, J. M.; Hutchinson, E. K.; Pate, K. A.; Witwer, K. W.

10.1101/2021.07.28.454192 — pharmacology and toxicology — Posted on 2022-01-14

2341 Radial-axial transport coordination enhances sugar translocation in the phloem vasculature of plants

Nakad, M.; Domec, J.-C.; Sevanto, S. A.; Katul, G. G.

10.1101/2021.09.24.461704 — biophysics — Posted on 2022-01-14

2342 GoPeaks: Histone Modification Peak Calling for CUT&Tag

Yashar, W. M.; Kong, G.; VanCampen, J.; Smith, B. M.; Coleman, D. J.; Carbone, L.; Yardimci, G. G.; Maxson, J. E.; Braun, T. P.

10.1101/2022.01.10.475735 — bioinformatics — Posted on 2022-01-14

2343 Enumeration of Citrus endophytic bacterial communities based on illumine metagenomics technique

Atta, S.

10.1101/2022.01.13.476241 — genetics — Posted on 2022-01-13

2344 Population demography maintains biogeographic boundaries

Schmidt, C.; Munoz, G.; Lancaster, L. T.; Lessard, J.-P.; Marske, K. A.; Marshall, K. E.; Garroway, C. J.

10.1101/2022.01.13.476105 — ecology — Posted on 2022-01-13

2345 Local-scale virome depiction supports significant differences between Aedes aegypti and Aedes albopictus

Calle-Tobon, A.; Perez-Perez, J.; Forero-Pineda, N.; Chavez, O. T.; Rojas-Montoya, W.; Rua-Uribe, G.; Gomez-Palacio, A.

10.1101/2022.01.13.476242 — microbiology — Posted on 2022-01-13

2346 Detailed measurements and simulations of electric field distribution of two TMS coils cleared for obsessive compulsive disorder in the brain and in specific regions associated with OCD

Tzirini, M.; Roth, Y.; Harmelech, T.; Zibman, S.; Pell, G. S.; Kimiskidis, V. K.; Tendler, A.; Zangen, A.; Samaras, T.

10.1101/2022.01.13.476243 — neuroscience — Posted on 2022-01-13

2347 Invariance in pitch perception

McPherson, M. J.; McDermott, J. H.

10.1101/2022.01.13.476197 — neuroscience — Posted on 2022-01-13

2348 Histopathological analysis of selected organs of Oreochromis niloticus due to sub-lethal industrial effluents exposure.

Ishaq, S.; Jabeen, G.; Manzoor, F.

10.1101/2022.01.13.476240 — zoology — Posted on 2022-01-13

2349 Chemical control and herbicide resistance of hairy fleabane in Jordan

Qasem, J. R.

10.1101/2022.01.13.476249 — plant biology — Posted on 2022-01-13

2350 Histopathological analysis of selected organs of Oreochromis niloticus due to sub-lethal industrial effluents exposure.

Ishaq, S.; Jabeen, G.; Manzoor, F.

10.1101/2022.01.13.476240 — zoology — Posted on 2022-01-13

2351 Identification of candidate virulence loci in Striga hermonthica, a devastating parasite of African cereal crops

Qiu, S.; Bradley, J. M.; Zhang, P.; Chaudhuri, R.; Blaxter, M.; Butlin, R. K.; Scholes, J. D.

10.1101/2022.01.13.476148 — plant biology — Posted on 2022-01-13

2352 Ocimum sanctum, OscWRKY1, regulates phenylpropanoid pathway genes and promotes resistance to pathogen infection in Arabidopsis

Joshi, A.; Jeena, G. S.; Shikha, ; Kumar, R.; Pandey, A.; Shukla, R.

10.1101/2022.01.12.474522 — plant biology — Posted on 2022-01-13

2353 Local-scale virome depiction supports significant differences between Aedes aegypti and Aedes albopictus

Calle-Tobon, A.; Perez-Perez, J.; Forero-Pineda, N.; Chavez, O. T.; Rojas-Montoya, W.; Rua-Uribe, G.; Gomez-Palacio, A.

10.1101/2022.01.13.476242 — microbiology — Posted on 2022-01-13

2354 Systematic analysis of human antibody response to ebolavirus glycoprotein reveals high prevalence of neutralizing public clonotypes

Chen, E. C.; Gilchuk, P.; Zost, S. J.; Ilinykh, P. A.; Binshtein, E.; Huang, K.; Myers, L.; Bonissone, S.; Day, S.; Kona, C. R.; Trivette, A.; Reidy, J. X.; Sutton, R. E.; Gainza, C.; Monroig, S.; Davidson, E.; Saphire, E. O.; Doranz, B. J.; Castellana, N.; Bukreyev, A.; Carnahan, R. H.; Crowe, J. E.

10.1101/2022.01.12.476089 — immunology — Posted on 2022-01-13

2355 Detailed measurements and simulations of electric field distribution of two TMS coils cleared for obsessive compulsive disorder in the brain and in specific regions associated with OCD

Tzirini, M.; Roth, Y.; Harmelech, T.; Zibman, S.; Pell, G. S.; Kimiskidis, V. K.; Tendler, A.; Zangen, A.; Samaras, T.

10.1101/2022.01.13.476243 — neuroscience — Posted on 2022-01-13

2356 Comparable human spatial memory distortions in physical, desktop virtual and immersive virtual environments

Zisch, F.; Newton, C.; Coutrot, A.; Murcia-Lopez, M.; Motala, A.; Greaves, J.; de Cothi, W.; Steed, A.; Tyler, N.; Gage, S. A.; Spiers, H. J.

10.1101/2022.01.11.475791 — neuroscience — Posted on 2022-01-13

2357 Role of Yap1 in adult neural stem cell activation

Berninger, B.; Fan, W.; Jurado-Arjona, J.; Alanis-Lobato, G.; Peron, S.; Berger, C.; Andrade-Navarro, M. A.; Falk, S.

10.1101/2022.01.12.475985 — neuroscience — Posted on 2022-01-13

2358 Chemical control and herbicide resistance of hairy fleabane in Jordan

Qasem, J. R.

10.1101/2022.01.13.476249 — plant biology — Posted on 2022-01-13

2359 Inhibition of the JAK/STAT pathway with baricitinib reduces the multiple organ dysfunction caused by hemorrhagic shock in rats

Patel, N. M.; Collotta, D.; Aimaretti, E.; Ferreira Alves, G.; Kröller, S.; Coldewey, S. M.; Collino, M.; Thiemermann, C.

10.1101/2022.01.13.476088 — pharmacology and toxicology — Posted on 2022-01-13

2360 Von Willebrand factor A1 domain affinity for GPIbα and stability are differentially regulated by its O-glycosylated N-linker and C-linker

Iacob, R.; Bonazza, K.; Hudson, N.; Li, J.; Lu, C.; Engen, J. R.; Springer, T. A.

10.1101/2022.01.13.476208 — biophysics — Posted on 2022-01-13

2361 Continuous B- to A- Transition in Protein-DNA Binding - How Well Is It Described by Current AMBER Force Fields?

Jurecka, P.; Zgarbova, M.; Cerny, F.; Salomon, J.

10.1101/2022.01.13.476176 — biophysics — Posted on 2022-01-13

2362 Histone chaperones exhibit conserved functionality in nucleosome remodeling

Buzon, P.; Velazquez-Cruz, A.; Gonzalez-Arzola, K.; Diaz-Quintana, A.; Diaz-Moreno, I.; Roos, W. H.

10.1101/2022.01.13.476140 — biophysics — Posted on 2022-01-13

2363 Dynamic Determinants of Quorum Quenching Mechanism Shared among N-terminal Serine Hydrolases

Surpeta, B.; Grulich, M.; Palyzova, A.; Maresova, H.; Brezovsky, J.

10.1101/2022.01.13.476167 — biochemistry — Posted on 2022-01-13

2364 Deep Proteome Profiling Enabled Functional Annotation and Data-Independent Quantification of Proline Hydroxylation Targets

Gong, Y.; Behera, G.; Erber, L.; Luo, A.; Chen, Y.

10.1101/2022.01.12.474993 — biochemistry — Posted on 2022-01-13

2365 Dissecting the interactions of PINK1 with the TOM complex in depolarized mitochondria

Maruszczak, K.; Jung, M.; Rasool, S.; Trempe, J.-F.; Rapaport, D.

10.1101/2022.01.13.476189 — biochemistry — Posted on 2022-01-13

2366 In vivo single-cell profiling of lncRNAs during Ebola virus infection

Santus, L.; Garcia-Perez, R.; Sopena-Rios, M.; Lin, A. E.; Adams, G. C.; Barnes, K. G.; Siddle, K. J.; Wohl, S.; Reverter, F.; Rinn, J. L.; Bennett, R. S.; Hensley, L. E.; Sabeti, P. C.; Mele, M.

10.1101/2022.01.12.476002 — genomics — Posted on 2022-01-13

2367 A high-resolution comparative atlas across 74 fish genomes illuminates teleost evolution after whole-genome duplication

Parey, E.; Louis, A.; Monfort, J.; Guiguen, Y.; Roest Crollius, H.; Berthelot, C.

10.1101/2022.01.13.476171 — genomics — Posted on 2022-01-13

2368 Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons

Macdonald, L. A.; Taylor, G. C. A.; Brisbane, J. M.; Christodoulou, E.; Scott, L.; Von Kriegsheim, A.; Rossant, J. J.; Gu, B.; Wood, A. J.

10.1101/2022.01.13.476100 — genetics — Posted on 2022-01-13

2369 Enumeration of Citrus endophytic bacterial communities based on illumine metagenomics technique

Atta, S.

10.1101/2022.01.13.476241 — genetics — Posted on 2022-01-13

2370 Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafish

Godivier, J.; Lawrence, E. A.; Wang, M.; Hammond, C. L.; Nowlan, N. C.

10.1101/2022.01.13.476166 — developmental biology — Posted on 2022-01-13

2371 Persistence of parental age effect on somatic mutation rates across generations in Arabidopsis.

Ramamurthy, B.; Bhushan, S.; Singh, A. K.; Thakur, Y.

10.1101/2022.01.12.476102 — developmental biology — Posted on 2022-01-13

2372 Hypercapnia limits β-catenin mediated alveolar type 2 cell progenitor function by altering Wnt production from adjacent fibroblasts

Dada, L. A.; Welch, L. C.; Magnani, N. D.; Ren, Z.; Brazee, P. L.; Celli, D.; Flozak, A. S.; Weng, A.; Maciel-Herrerias, M.; Kryvenko, V.; Vadasz, I.; Runyan, C. E.; Abdala-Valencia, H.; Shigemura, M.; Casalino-Matsuda, S. M.; Misharin, A. V.; Budinger, G. R. S.; Gottardi, C. J.; Sznajder, J. I.

10.1101/2022.01.12.475264 — cell biology — Posted on 2022-01-13

2373 Optineurin mediates delivery of membrane from transferrin receptor-positive endosomes to autophagosomes

Bansal, M.; Sirohi, K.; Moharir, S. C.; Swarup, G.

10.1101/2022.01.12.476135 — cell biology — Posted on 2022-01-13

2374 cGAS recruitment to micronuclei is dictated by pre-existing nuclear chromatin status.

MacDonald, K. M.; Nicholson-Puthenveedu, S.; Tageldein, M. M.; Arrowsmith, C.; Harding, S. M.

10.1101/2022.01.13.476191 — cell biology — Posted on 2022-01-13

2375 Proteasome granular localization is regulated through mitochondrial respiration and kinase signaling

Waite, K. A.; Roelofs, J.

10.1101/2022.01.13.476202 — cell biology — Posted on 2022-01-13

2376 Overexpression of miR5505 enhanced drought and salt resistance in rice (Orayza sativa)

FAN, Y.; Zhang, F.; Xie, J.

10.1101/2022.01.13.476146 — molecular biology — Posted on 2022-01-13

2377 A truncated form of the p27 CDK inhibitor translated from pre-mRNA causes cell cycle arrest at G2 phase

Kaida, D.; Satoh, T.; Ishida, K.; Yoshimoto, R.

10.1101/2022.01.12.476115 — molecular biology — Posted on 2022-01-13

2378 Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021

Caliendo, V.; Lewis, N. S.; Pohlmann, A.; Waldenstrom, J.; van Toor, M.; Lameris, T.; van der Jeugd, H.; Lang, A. S.; Robertson, G.; Beer, M.; Fouchier, R.; Banyard, A. C.; Brown, I. H.; Berhana, Y.; Laurendeau, S.; Kuiken, T.; Hansen, R.; Yason, C.; Alkie, T.; Lung, O.; Baillie, S.; Thorup, K.

10.1101/2022.01.13.476155 — microbiology — Posted on 2022-01-13

2379 Standard selection treatments with sulfadiazine limit Plasmodium yoelii host-to-vector transmission

Rios, K. T.; Dickson, T. M.; Lindner, S. E.

10.1101/2022.01.13.476179 — microbiology — Posted on 2022-01-13

2380 Bifidobacterium longum attenuates ovariectomy-induced bone loss via modulating the Immunoporotic Breg-Treg-Th17 cell axis

Sapra, L.; Shokeen, N.; Gupta, K.; Saini, C.; Bhardwaj, A.; Mathew, M.; Mishra, P. K.; Chattopadhyay, N.; Verma, B.; Srivastava, R. K.

10.1101/2022.01.13.476144 — immunology — Posted on 2022-01-13

2381 AAV11 permits efficient retrograde targeting of projection neurons

Han, Z.; Luo, N.; Kou, J.; Li, L.; Ma, W.; Peng, S.; Xu, Z.; Zhang, W.; Qiu, Y.; Wu, Y.; Wang, J.; Ye, C.; Lin, K.; Xu, F.

10.1101/2022.01.13.476170 — neuroscience — Posted on 2022-01-13

2382 Site-specific adaptation mechanisms of an oral pathobiont in the oral and gut mucosae

Guo, Y.; Kitamoto, S.; Caballero-Flores, G.; Watanabe, D.; Sugihara, K.; Nunez, G.; Alteri, C. J.; Inohara, N.; Kamada, N.

10.1101/2022.01.13.476151 — microbiology — Posted on 2022-01-13

2383 The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

Yuan, S.; Ye, Z.-W.; Liang, R.; Tang, K.; Zhang, A. J.; Lu, G.; Ong, C. P.; Poon, V. K.-M.; Chan, C. C.-S.; Mok, B. W. Y.; Qin, Z.; Xie, Y.; Sun, H.; Tsang, J. O.-L.; Yuen, T. T.-T.; Chik, K. K.-H.; Chan, C. C.-Y.; Cai, J.-P.; Luo, C.; Lu, L.; Yip, C. C.-Y.; Chu, H.; To, K. K.-W.; Chen, H.; Jin, D.-Y.; Yuen, K.-Y.; Chan, J. F. W.

10.1101/2022.01.12.476031 — microbiology — Posted on 2022-01-13

2384 Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, beta, delta, and omicron variants

Banerjee, A.; Lew, J.; Kroeker, A.; Baid, K.; Aftanas, P.; Nirmalarajah, K.; Maguire, F.; Kozak, R.; McDonald, R.; Lang, A.; Gerdts, V.; Straus, S. E.; Gilbert, L.; Li, A. X.; Mozafarihasjin, M.; Walmsley, S.; Gingras, A.-C.; Wrana, J. L.; Mazzulli, T.; Colwill, K.; McGeer, A. J.; Mubareka, S.; Falzarano, D.

10.1101/2022.01.13.475409 — immunology — Posted on 2022-01-13

2385 An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer

Suryadevara, N.; Shiakolas, A.; VanBlargan, L.; Binshtein, E.; Chen, R.; Case, J. B.; Kramer, K.; Armstrong, E.; Myers, L.; Trivette, A.; Gainza, C.; Nargi, R.; Selverian, C.; Davidson, E.; Doranz, B.; Diaz, S.; Handal, L.; Carnahan, R. H.; Diamond, M. S.; Georgiev, I.; Crowe, J. E.

10.1101/2022.01.12.476120 — immunology — Posted on 2022-01-13

2386 matOptimize: A parallel tree optimization method enables online phylogenetics for SARS-CoV-2

Ye, C.; Thornlow, B.; Hinrichs, A. S.; Torvi, D.; Lanfear, R.; Corbett-Detig, R.; Turakhia, Y.

10.1101/2022.01.12.475688 — evolutionary biology — Posted on 2022-01-13

2387 COVID-19 vaccine booster induces a strong CD8+ T cell response against Omicron variant epitopes in HLA-A*02:01+ individuals

Nguyen, A. T.; Szeto, C.; Chatzileontiadou, D. S. M.; Tong, Z. W. M.; Dewar-Oldis, M. J.; Cooper, L.; Murdolo, L. D.; Chew, K. Y.; Lineburg, K. E.; Riboldi-Tunicliffe, A.; Williamson, R.; Gardiner, B. J.; Jayasinghe, D.; Lobos, C. A.; Ahn, Y. M.; Grant, E. J.; Smith, C.; McMahon, J.; Good-Jacobson, K. L.; Barnard, P. J.; Short, K. R.; Gras, S.

10.1101/2022.01.12.473243 — immunology — Posted on 2022-01-13

2388 Mouse lemur, a new primate model to investigate cardiac pacemaker activity.

DiFrancesco, M. L.; Davaze, R.; Torre, E.; Mesirca, P.; Marrot, M.; Lautier, C.; Fontes, P.; Cuoq, J.; Fernandez, A.; Pifferi, F.; Mestre Frances, N.; Mangoni, M. E.; Torrente, A. G.

10.1101/2021.10.25.465774 — physiology — Posted on 2022-01-13

2389 Bioprinting the Tumor Microenvironment with an Upgraded Consumer Stereolithographic 3D Printer

Breideband, L.; Wächtershäuser, K. N.; Hafa, L.; Wieland, K.; Frangakis, A.; Stelzer, E. H. K.; Pampaloni, F.

10.1101/2021.12.30.474546 — bioengineering — Posted on 2022-01-13

2390 Sibling rivalry among the ZBTB transcription factor family: homo vs. heterodimers

Piepoli, S.; Nogay, L.; Akkose, U.; Barakat, S.; Taskiran, H.; Tolay, N.; Gezen, M.; Adebali, O.; Atilgan, C.; Erman, B.

10.1101/2021.12.17.472994 — molecular biology — Posted on 2022-01-13

2391 Dynamic analysis and control of a rice-pest system under transcritical bifurcations

Mandal, S.; Oberst, S.; Biswas, M. H. A.; Islam, M. S.

10.1101/2021.09.07.459216 — systems biology — Posted on 2022-01-13

2392 The Mechanisms of GPR55 Receptor Functonal Selectivity

Akimov, M. G.; Gretskaya, N. M.; Dudina, P. V.; Sherstyanykh, G.; Zinchenko, G. N.; Serova, O. V.; Degtyaryova, K. O.; Deyev, I. E.; Bezuglov, V. V.

10.1101/2022.01.12.476071 — cell biology — Posted on 2022-01-13

2393 Climate change impacts on the abiotic degradation of acyl-homoserine lactones in the fluctuating conditions of marine biofilms

Roggatz, C. C.; Parsons, D. R.

10.1101/2022.01.12.476096 — microbiology — Posted on 2022-01-13

2394 SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

Meng, B.; Ferreira, I.; Abdullahi, A.; Goonawardane, N.; Saito, A.; Kimura, I.; Yamasoba, D.; Kemp, S. A.; Papa, G.; Fatihi, S.; Rathore, S.; Perera Gerba, P.; Ikeda, T.; Toyoda, M.; Tan, T. S.; Kuramochi, J.; Mitsunaga, S.; Ueno, T.; Charles, O.; Collier, D.; CITIID-NIHR BioResource COVID-19 Collaboration, ; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Ecuador-COVID19 Consortium, ; Bradley, J.; Choi, J.; Smith, K.; Madissoon, E.; Meyer, K.; Mlcochova, P.; Doffinger, R.; Teichmann, S. A.; James, L.; Hyeon Lee, J.; Brevini, T.; Pizzuto, M.; Hosmillo, M.; Mallery, D.; Zepeda, S.;

10.1101/2021.12.17.473248 — microbiology — Posted on 2022-01-13

2395 Convergent coding of recent and remote fear memory in the basolateral amygdala

Liu, J.; Totty, M. S.; Melissari, L.; Bayer, H.; Maren, S.

10.1101/2021.09.27.462008 — neuroscience — Posted on 2022-01-13

2396 Dynamic control systems that mimic natural regulation of catabolic pathways enable rapid production of lignocellulose-derived bioproducts

Elmore, J. R.; Peabody, G. L.; Jha, R. K.; Dexter, G. N.; Dale, T.; Guss, A. M.

10.1101/2022.01.12.475730 — synthetic biology — Posted on 2022-01-13

2397 Autophagy is impaired in fetal hypoplastic lungs and rescued by administration of amniotic fluid stem cell extracellular vesicles

Khalaj, K.; Antounians, L.; Figueira, R. L.; Post, M.; Zani, A.

10.1101/2022.01.12.476078 — developmental biology — Posted on 2022-01-13

2398 A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

Wang, X.; Hu, A.; Chen, X.; Zhang, Y.; Yu, F.; Yue, S.; Li, A.; Zhang, J.; Pan, Z.; Yang, Y.; Lin, Y.; Gao, L.; Zhou, J.; Zhao, J.; Li, F.; Shi, Y.; Huang, F.; Yang, X.; Peng, Y.; Tu, L.; Zhang, H.; Zheng, H.; He, J.; Zhang, H.; Xu, L.; Huang, Q.; Zhu, Y.; Deng, K.; Ye, L.

10.1101/2021.11.29.470356 — immunology — Posted on 2022-01-13

2399 Antisense oligonucleotide-based therapeutic strategy for progranulin-deficient frontotemporal dementia

Aggarwal, G.; Banerjee, S.; Jones, S. A.; Pavlack, M. D.; Benchaar, Y.; Belanger, J.; Sevigny, M.; Smith, D. M.; Niehoff, M. L.; de Vera, I. M. S.; Petkau, T. L.; Leavitt, B. R.; Ling, K.; Jafar-Nejad, P.; Rigo, F. D.; Morley, J. E.; Farr, S. A.; Dutchak, P. A.; Sephton, C. F.; Nguyen, A. D.

10.1101/2022.01.12.476053 — neuroscience — Posted on 2022-01-13

2400 A Precision Functional Atlas of Network Probabilities and Individual-Specific Network Topography

Hermosillo, R. J.; Moore, L. A.; Feczko, E. J.; Pines, A. R.; Dworetsky, A.; Conan, G.; Mooney, M. A.; Randolph, A.; Adeyemo, B.; Earl, E.; Perrone, A.; Carrasco, C. M.; Uriarte-Lopez, J.; Snider, K.; Doyle, O.; Cordova, M.; Nagel, B. J.; Ewing, S. W. F.; Satterthwaite, T. D.; Dosenbach, N.; Gratton, C.; Petersen, S.; Dominguez, O. M.; Fair, D. A.

10.1101/2022.01.12.475422 — neuroscience — Posted on 2022-01-13

2401 Flexible cue anchoring strategies enable stable head direction coding in both sighted and blind animals

Asumbisa, K.; Peyrache, A.; Trenholm, S.

10.1101/2022.01.12.476111 — neuroscience — Posted on 2022-01-13

2402 Semi-field evaluations of three botanically derived repellents against the blacklegged tick, Ixodes scapularis (Acari: Ixodidae)

Lee, X.; Wong, C.; Coats, J.; Paskewitz, S. M.

10.1101/2022.01.12.476114 — zoology — Posted on 2022-01-13

2403 An in silico method to assess antibody fragment polyreactivity

Harvey, E. P.; Shin, J.-E.; Skiba, M. A.; Nemeth, G. R.; Hurley, J. D.; Wellner, A.; Shaw, A. Y.; Miranda, V. G.; Min, J. K.; Liu, C. C.; Marks, D. S.; Kruse, A.

10.1101/2022.01.12.476085 — pharmacology and toxicology — Posted on 2022-01-13

2404 Sequence Coverage Visualizer: A web application for protein sequence coverage 3D visualization

Shao, X.; Grams, C.; Gao, Y.

10.1101/2022.01.12.476109 — bioinformatics — Posted on 2022-01-13

2405 EZ Clear for simple, rapid, and robust mouse whole organ clearing

Hsu, C.-W.; Cerda, J.; Kirk, J. M.; Turner, W. D.; Rasmussen, T. L.; Dickinson, M. E.; Suarez, C. P. F.; Wythe, J.

10.1101/2022.01.12.476113 — developmental biology — Posted on 2022-01-13

2406 Enhanced food motivation in obese mice is controlled by D1R expressing spiny projection neurons in the nucleus accumbens.

Matikainen-Ankney, B. A.; Legaria, A. A.; Vachez, Y. M.; Murphy, C. A.; Pan, Y. A.; Schaefer, R. F.; McGrath, Q. J.; Wang, J. G.; Bluitt, M. N.; Norris, A. J.; Creed, M. C.; Kravitz, A. V.

10.1101/2022.01.12.476057 — neuroscience — Posted on 2022-01-13

2407 Explainable t-SNE for single-cell RNA-seq data analysis

Han, H.; Zhang, T.; Benton, M. L.; Li, C.; Wang, J.; Li, J.

10.1101/2022.01.12.476084 — bioinformatics — Posted on 2022-01-13

2408 Embracing curiosity eliminates the exploration-exploitation dilemma

Peterson, E. J.; Verstynen, T. V.

10.1101/671362 — animal behavior and cognition — Posted on 2022-01-13

2409 Comparative transcriptome investigation of Nosema ceranae infecting eastern honeybee workers

Yuanchan, F.; Chen, D.; Guo, R.

10.1101/2022.01.12.476029 — molecular biology — Posted on 2022-01-13

2410 Cattle T Cell Phenotyping by an 8-Colour, 10-Parameter Panel

Roos, E. O.; Mwangi, W.; Gerner, W.; Waters, R.; Hammond, J. A.

10.1101/2022.01.12.476027 — immunology — Posted on 2022-01-13

2411 Parent-Child Autonomic Synchrony During Vicarious Extinction Learning in Pediatric PTSD

George, G. C.; Heyn, S. A.; Konishi, S.; Marin, M.-F.; Milad, M. R.; Herringa, R. J.

10.1101/2022.01.12.476063 — neuroscience — Posted on 2022-01-13

2412 Exogenous capture accounts for fundamental differences between prosaccade and antisaccade performance

Goldstein, A. T.; Stanford, T. R.; Salinas, E.

10.1101/2022.01.12.476074 — neuroscience — Posted on 2022-01-13

2413 Cisplatin neurotoxicity targets specific subpopulations and K+ channels in tyrosine-hydroxylase positive dorsal root ganglia neurons

Finno, C. J.; Chen, Y.; Park, S.; Lee, J. H.; Perez-Flores, C. M.; Yamoah, E.

10.1101/2022.01.12.476091 — neuroscience — Posted on 2022-01-13

2414 A neural network model of hippocampal contributions to category learning

Sucevic, J.; Schapiro, A. C.

10.1101/2022.01.12.476051 — neuroscience — Posted on 2022-01-13

2415 A whole-cell recording database of neuromodulatory action in the adult neocortex

Yan, X.; Calcini, N.; Safavi, P.; Ak, A.; Kole, K.; Zeldenrust, F.; Celikel, T.

10.1101/2022.01.12.476007 — neuroscience — Posted on 2022-01-13

2416 Bulk and Single-nucleus Transcriptomics Highlight Intra-telencephalic and Somatostatin Neurons in Alzheimer's Disease

Consens, M. E.; Chen, Y.; Menon, V.; Wang, Y.; Schneider, J. A.; De Jager, P. L.; Bennett, D. A.; Tripathy, S. J.; Felsky, D.

10.1101/2022.01.12.476076 — neuroscience — Posted on 2022-01-13

2417 Scalable in situ single-cell profiling by electrophoretic capture of mRNA

Borm, L.; Albiach, A. M.; Mannens, C. C.; Janusauskas, J.; Özgün, C.; Fernandez Garcia, D.; Hodge, R. D.; Lein, E.; Codeluppi, S.; Linnarsson, S.

10.1101/2022.01.12.476082 — neuroscience — Posted on 2022-01-13

2418 Theory for weakly polydisperse cytoskeleton filaments

Warshavsky, V.; Marucho, M.

10.1101/2022.01.12.476073 — neuroscience — Posted on 2022-01-13

2419 Accounting for motion in fMRI: What part of the spectrum are we characterizing in autism spectrum disorder?

Nebel, M. B.; Lidstone, D.; Wang, L.; Benkeser, D.; Mostofsky, S. H.; Risk, B. B.

10.1101/2022.01.12.476077 — neuroscience — Posted on 2022-01-13

2420 A Systematic, Complexity-Reduction Approach to Dissect Microbiome: the Kombucha Tea Microbiome as an Example

Huang, X.; Xin, Y.; Lu, T.

10.1101/2022.01.12.475982 — systems biology — Posted on 2022-01-13

2421 A thermodynamic model for water activity and redox potential in evolution and development

Dick, J. M.

10.1101/2021.01.29.428804 — biochemistry — Posted on 2022-01-13

2422 Brain charts for the human lifespan

Bethlehem, R. A. I.; Seidlitz, J.; White, S. R.; Vogel, J. W.; Anderson, K. M.; Adamson, C.; Adler, S.; Alexopoulos, G. S.; Anagnostou, E.; Areces-Gonzalez, A.; Astle, D. E.; Auyeung, B.; Ayub, M.; Ball, G.; Baron-Cohen, S.; Beare, R.; Bedford, S. A.; Benegal, V.; Beyer, F.; Bin Bae, J.; Blangero, J.; Blesa Cabez, M.; Boardman, J. P.; Borzage, M.; Bosch-Bayard, J. F.; Bourke, N.; Calhoun, V. D.; Chakravarty, M. M.; Chen, C.; Chertavian, C.; Chetelat, G.; Chong, Y. S.; Cole, J. H.; Corvin, A.; Costantino, M.; Courchesne, E.; Crivello, F.; Cropley, V. L.; Crosbie, J.; Crossley, N.; Delarue, M.;

10.1101/2021.06.08.447489 — neuroscience — Posted on 2022-01-13

2423 DNA as a Recyclable Natural Polymer

Liu, W.; Giaveri, S.; Ortiz, D.; Stellacci, F.

10.1101/2021.08.31.458327 — biochemistry — Posted on 2022-01-13

2424 Alkaloid avoidance in poison frog tadpoles

Sanchez, E.; Ramirez, T.; O'Connell, L. A.

10.1101/2022.01.12.476122 — animal behavior and cognition — Posted on 2022-01-13

2425 Complement facilitates developmental microglial pruning of astrocyte and vascular networks

Gnanaguru, G.; Tabor, S. J.; Yuda, K.; Mukai, R.; Köhl, J.; Connor, K. M.

10.1101/2022.01.12.476001 — developmental biology — Posted on 2022-01-13

2426 Cryo-EM Structure of Adeno-associated virus-4 at 2.2 A resolution

Zane, G. M.; Silveria, M. A.; Meyer, N. L.; White, T. A.; Chapman, M. S.

10.1101/2022.01.12.476110 — microbiology — Posted on 2022-01-13

2427 PFTK1 kinase regulates axogenesis during development via RhoA activation.

Joselin, A.; Rodriguez Gonzalez, Y.; Kamkar, F.; Jafar-nejad, P.; Wang, S.; Qu, D.; Sanchez Alvarez, L.; Hawari, D.; Sonnenfeld, M.; Slack, R. S.; Albert, P.; Park, D. S.

10.1101/2022.01.11.475789 — neuroscience — Posted on 2022-01-13

2428 Joint modeling of choices and reaction times based on Bayesian contextual behavioral control

Schwöbel, S.; Markovic, D.; Smolka, M. N.; Kiebel, S.

10.1101/2021.10.29.466505 — neuroscience — Posted on 2022-01-13

2429 PVT1, a YAP1 dependent stress responsive lncRNA drives ovarian cancer metastasis and chemoresistance

Tabury, K.; Monavarian, M.; Listik, E.; Shelton, A. K.; Choi, A. S.; Quintens, R.; Arend, R. C.; Hempel, N.; Miller, C. R.; Györrfy, B.; Mythreye, K.

10.1101/2022.01.11.475893 — cancer biology — Posted on 2022-01-13

2430 Ancestral acetylcholine receptor β-subunit forms homopentamers that prime before opening spontaneously

Tessier, C. J. G.; Sturgeon, R. M.; Emlaw, J. R.; McCluskey, G. D.; Perez-Areales, F. J.; daCosta, C. J. B.

10.1101/2022.01.12.475990 — biophysics — Posted on 2022-01-13

2431 Cell- and non-cell-autonomous ARF3 coordinates meristem proliferation and organ patterning in Arabidopsis

Liu, X.; Zhang, K.; Zhang, H.; Pan, Y.; Guo, L.; Tian, S.; Wei, J.; Fu, Y.; Wang, C.; Qu, P.; Liu, L.; Zhang, Y.; Sun, H.; Bai, Z.; Dong, J.; Li, C.

10.1101/2022.01.12.476103 — developmental biology — Posted on 2022-01-13

2432 Benchmarking taxonomic classifiers with Illumina and Nanopore sequence data for clinical metagenomic diagnostic applications

Govender, K. N.; Eyre, D. W.

10.1101/2022.01.11.475979 — microbiology — Posted on 2022-01-13

2433 robustica: customizable robust independent component analysis

Anglada-Girotto, M.; Miravet-Verde, S.; Serrano, L.; Head, S. A.

10.1101/2021.12.10.471891 — systems biology — Posted on 2022-01-13

2434 Pachytene karyotypes of 17 species of birds

Slobodchikova, A.; Malinovskaya, L.; Grishko, E.; Pristyazhnyuk, I.; Torgasheva, A.; Borodin, P.

10.1101/2022.01.01.473627 — genetics — Posted on 2022-01-13

2435 Germline-soma Supply Mitochondria for mtDNA Inheritance in Mouse Oogenesis

Sha, H.; Ye, Z.; Ye, Z.; Shi, S.; Pan, J.; Dong, X.; Zhao, Y.

10.1101/2022.01.11.475948 — developmental biology — Posted on 2022-01-13

2436 Perceptual decisions and oculomotor responses rely on temporally distinct streams of evidence

Lisi, M.; Morgan, M. J.; Solomon, J. A.

10.1101/2020.03.31.018655 — neuroscience — Posted on 2022-01-13

2437 Unifying Gene Expression Complexity and Cellular Operational Efficiency: Application of the Locality and Caching Principles via a Cell-to-Computer Analogy

Jiang, W.; Feliers, D.; Zheng, W. J.; Zhang, F.; Wang, D.

10.1101/2022.01.11.475967 — systems biology — Posted on 2022-01-13

2438 A mixture of innate cryoprotectants is key for freeze tolerance and cryopreservation of a drosophilid fly larva.

Kucera, L.; Moos, M.; Stetina, T.; Korbelova, J.; Vodrazka, P.; Des Marteaux, L.; Grgac, R.; Hula, P.; Rozsypal, J.; Faltus, M.; Simek, P.; Sedlacek, R.; Kostal, V.

10.1101/2021.12.15.472769 — physiology — Posted on 2022-01-13

2439 Multimodal cues displayed by submissive rats promote prosocial choices by dominants

Gachomba, M. J. M.; Esteve-Agraz, J.; Caref, K.; Sanz-Maroto, A.; Bortolozzo-Gleich, H.; Laplagne, D. A.; Marquez, C.

10.1101/2022.01.12.475866 — neuroscience — Posted on 2022-01-13

2440 Emergence of Heartbeat Frailty in Advanced Age: Perspectives from Life-Long EKG Recordings in Mice

Moen, J. M.; Morrell, C. H.; Ahmet, I.; Matt, M. G.; Davoodi, M.; Petr, M.; Charles, S.; deCabo, R.; Yaniv, Y.; Lakatta, E. G.

10.1101/2022.01.12.475659 — physiology — Posted on 2022-01-12

2441 Epigenetic dysregulation from chromosomal transit in micronuclei

Agustinus, A.; Raviram, R.; Dameracharla, B.; Luebeck, J.; Stransky, S.; Scipioni, L.; Myers, R.; DiBona, M.; Duran, M.; Weigelt, B.; Yomtoubian, S.; Toufektchan, E.; Mischel, P.; Mittal, V.; Shah, S.; Maciejowski, J.; Gratton, E.; Ly, P.; Bakhoum, M.; Landau, D.; Bafna, V.; Sidoli, S.; David, Y.; Bakhoum, S. F.

10.1101/2022.01.12.475944 — cancer biology — Posted on 2022-01-12

2442 Label-free sensing of cells with fluorescence lifetime imaging: the quest for metabolic heterogeneity

Shirshin, E. A.; Shirmanova, M. V.; Gayer, A. V.; Lukina, M. M.; Nikonova, E. E.; Yakimov, B. P.; Budylin, G. S.; Dudenkova, V. V.; Ignatova, N. I.; Komarov, D. V.; Yakovlev, V. V.; Becker, W.; Zagaynova, E. V.; Shcheslavskiy, V. V.; Scully, M. O.

10.1101/2022.01.12.476038 — cancer biology — Posted on 2022-01-13

2443 Conformational entropy limits the transition from nucleation to elongation in amyloid aggregation

Phan, T. M.; Schmit, J. D.

10.1101/2020.06.22.165423 — biophysics — Posted on 2022-01-13

2444 Precise Transcript Reconstruction with End-Guided Assembly

Schon, M. A.; Lutzmayer, S.; Hofmann, F.; Nodine, M. D.

10.1101/2022.01.12.476004 — bioinformatics — Posted on 2022-01-13

2445 OKseqHMM: a genome-wide replication fork directionality analysis toolkit

Liu, Y.; Wu, X.; D'aubenton-Carafa, Y.; Thermes, C.; Chen, C.-L.

10.1101/2022.01.12.476022 — bioinformatics — Posted on 2022-01-13

2446 Which lower-limb joints compensate for destabilising energy during walking in humans

Golyski, P. R.; Sawicki, G. S.

10.1101/2022.01.11.475955 — bioengineering — Posted on 2022-01-12

2447 Spatial MIST Technology for Rapid, Highly Multiplexed Detection of Protein Distribution on Brain Tissue

Reddy, R.; Yang, L.; Liu, J.; Liu, Z.; Wang, J.

10.1101/2022.01.11.475923 — bioengineering — Posted on 2022-01-13

2448 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases

Mehta, V.; Khanppnavar, B.; Schuster, D.; Kantarci, I.; Vercellino, I.; Kosturanova, A.; Iype, T.; Stefanic, S.; Picotti, P.; Korkhov, V. M.

10.1101/2021.12.01.470738 — biochemistry — Posted on 2022-01-13

2449 Quantitative Analysis of Genomic Sequences of Virus RNAs Using a Metric-Based Algorithm

Belinsky, A.; Kouzaev, G.

10.1101/2021.06.17.448868 — genomics — Posted on 2022-01-12

2450 An ancestral genomic sequence that serves as a nucleation site for de novo gene birth

Delihas, N.

10.1101/2022.01.12.475983 — genetics — Posted on 2022-01-12

2451 Rare Genetic Variants Correlate with Better Processing Speed

Song, Z.; Gurinovich, A.; Nygaard, M.; Mengel-From, J.; Andersen, S.; Cosentino, S.; Schupfs, N.; Lee, J.; Zmuda, J.; Ukraintseva, S.; Arbeev, K.; Christensen, K.; Perls, T.; Sebastiani, P.

10.1101/2022.01.12.476030 — genetics — Posted on 2022-01-12

2452 A method for partitioning trends in genetic mean and variance to understand breeding practices

Oliveira, T. d. P.; Obsteter, J.; Pocrnic, I.; Gorjanc, G.

10.1101/2022.01.10.475603 — genetics — Posted on 2022-01-12

2453 Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation

Fan, C. C.; Loughnan, R.; Pechva, D.; Chen, C.-H.; Hagler, D.; Thompson, W. K.; Parker, N.; van der Meer, D.; Frei, O.; Andreassen, O.; Dale, A. M.

10.1101/2021.06.24.449723 — genetics — Posted on 2022-01-13

2454 Haplotype-resolved powdery mildew resistance loci reveal the impact of heterozygous structural variation on NLR genes in Muscadinia rotundifolia

Massonnet, M.; Vondras, A. M.; Cochetel, N.; Riaz, S.; Pap, D.; Minio, A.; Figueroa-Balderas, R.; Walker, M. A.; Cantu, D.

10.1101/2021.11.23.469029 — genetics — Posted on 2022-01-13

2455 SNP-level FST outperforms window statistics for detecting soft sweeps in local adaptation

da Silva Ribeiro, T.; Galvan, J. A.; Pool, J. E.

10.1101/2022.01.12.476036 — evolutionary biology — Posted on 2022-01-12

2456 Multiple horizontal acquisitions of plant genes in the whitefly Bemisia tabaci

Gilbert, C.; Maumus, F.

10.1101/2022.01.12.476015 — evolutionary biology — Posted on 2022-01-12

2457 Horizontal Transfers Lead to the Birth of Momilactone Biosynthetic Gene Clusters in Grass

Wu, D.; Hu, Y.; Akashi, S.; Nojiri, H.; Ye, C.-Y.; Zhu, Q.-H.; Okada, K.; Fan, L.

10.1101/2022.01.11.475971 — evolutionary biology — Posted on 2022-01-12

2458 Individual variation in dispersal, and its sources, shape the fate of pushed vs. pulled range expansions

Dahirel, M.; Guicharnaud, C.; Vercken, E.

10.1101/2022.01.12.476009 — ecology — Posted on 2022-01-13

2459 Germline-soma Supply Mitochondria for mtDNA Inheritance in Mouse Oogenesis

Sha, H.; Ye, Z.; Ye, Z.; Shi, S.; Pan, J.; Dong, X.; Zhao, Y.

10.1101/2022.01.11.475948 — developmental biology — Posted on 2022-01-12

2460 Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection

Wang, J.; Han, M.; Roy, A. R.; Wang, H.; Moeckl, L.; Zeng, L.; Moerner, W. E.; Qi, L. S.

10.1101/2021.06.09.447760 — cell biology — Posted on 2022-01-13

2461 The RNA-Binding Protein SAM68 regulates cardiomyocyte differentiation by enhancing Gata4 translation

Dasti, A.; Antonelli, M. C.; Segura, M. A.; Armaos, A.; Bonnin, S.; Graf, T.; Paronetto, M. P.; Tian, T. V.; Bechara, E.; Tartaglia, G. G.

10.1101/2022.01.11.475875 — molecular biology — Posted on 2022-01-12

2462 Host tissue proteomics reveal insights into the molecular basis of Schistosoma haematobium-induced bladder pathology

Osakunor, D. N. M.; Ishida, K.; Lamanna, O. K.; Rossi, M.; Dwomoh, L.; Hsieh, M. H.

10.1101/2021.11.23.469626 — molecular biology — Posted on 2022-01-13

2463 Fibromodulin Ablation Exacerbates the Severity of Acute DSS Colitis

Halasi, M.; Grinstein, M.; Adini, A.; Adini, I.

10.1101/2022.01.12.475640 — immunology — Posted on 2022-01-12

2464 Dynamical Latent State Computation in the Posterior Parietal Cortex

Lakshminarasimhan, K. J.; Avila, E.; Pitkow, X.; Angelaki, D. E.

10.1101/2022.01.12.476065 — neuroscience — Posted on 2022-01-12

2465 Optimal control methods for nonlinear parameter estimation in biophysical neuron models

Kadakia, N.

10.1101/2022.01.11.475951 — neuroscience — Posted on 2022-01-12

2466 Heterosynaptic NMDA Receptor Plasticity in Hippocampal Dentate Granule Cells

Rodenas-Ruano, A.; Nasrallah, K.; Lutzu, S.; Castillo, M.; Castillo, P. E.

10.1101/2022.01.12.476040 — neuroscience — Posted on 2022-01-12

2467 Age-dependent increased sag current in human pyramidal neurons dampens baseline cortical activity

Guet-McCreight, A.; Chameh, H. M.; Mahallati, S.; Wishart, M.; Tripathy, S. J.; Valiante, T. A.; Hay, E.

10.1101/2021.11.03.467014 — neuroscience — Posted on 2022-01-12

2468 GR-regulated enhancers play a central role in the gene regulatory networks underlying drug addiction

Duttke, S.; Montilla-Perez, P.; Chang, M. W.; Li, H.; Chen, H.; Carrette, L. L. G.; de Guglielmo, G.; George, O.; Palmer, A. A.; Benner, C.; Telese, F.

10.1101/2022.01.12.475507 — neuroscience — Posted on 2022-01-12

2469 Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis

Killinger, B. A.; Brundin, P.; Kordower, J. H.; Mercado, G.; Choi, S. G.; Chu, Y.

10.1101/2021.12.22.473905 — neuroscience — Posted on 2022-01-12

2470 Regenerating aggregates of hydra display unique cytoskeletal organisation that is absent in a regeneration-deficient strain

Bhgavan, H.; Prabhu, S.; Govindasamy, N.; Ghanekar, Y.

10.1101/2022.01.11.466547 — zoology — Posted on 2022-01-12

2471 Approximated Gene Expression Trajectories (AGETs) for Gene Regulatory Network Inference on Cell Tracks

Spiess, K.; Fulton, T.; Hwang, S.; Toh, K.; Saunders, D.; Paige, B.; Steventon, B.; Verd, B.

10.1101/2022.01.12.476060 — systems biology — Posted on 2022-01-12

2472 Nonmodular oscillator and switch based on RNA decay drive regeneration of multimodal gene expression

Nordick, B.; Yu, P. Y.; Liao, G.; Hong, T.

10.1101/2022.01.12.475956 — systems biology — Posted on 2022-01-12

2473 A host-gut microbial co-metabolite of aromatic amino acids, p-cresol glucuronide, promotes blood-brain barrier integrity in vivo

Stachulski, A. V.; Knausenberger, T. B.-A.; Shah, S. N.; Hoyles, L.; McArthur, S.

10.1101/2022.01.11.475932 — systems biology — Posted on 2022-01-12

2474 Histone H3K4 methyltransferase DcATX1 promotes ethylene induced petal senescence in carnation

Feng, S.; Wang, R.; Tan, H.; Zhong, L.; Cheng, Y.; Bao, M.; Qiao, H.; Zhang, F.

10.1101/2022.01.12.476045 — plant biology — Posted on 2022-01-12

2475 Genetic diversity and population structure of sweet orange germplasm of India revealed by SSR and InDel markers

Jagannadham, P. T. K.; Anbalagan, T.; Upadhyay, D. Y.; Kamde, S. A.; Jalamkar, P. R.; Murkute, A. A.

10.1101/2022.01.11.475964 — plant biology — Posted on 2022-01-12

2476 A Protective Inter-Organ Communication Response Against Life-Threatening Malarial Anemia

Wu, Q.; Sacomboio, E.; Souza, L. V.; Martins, R.; Cardoso, S.; Ademolue, T. W.; Paixao, T.; Lehtimaki, J.; Norden, C.; Tharaux, P.-L.; Weiss, G.; Wang, F.; Ramos, S.; Soares, M. P.

10.1101/2022.01.12.475857 — pathology — Posted on 2022-01-12

2477 Single Cell Spatial Analysis Reveals the Topology of Immunomodulatory Purinergic Signaling in Glioblastoma

Coy, S.; Wang, S.; Stopka, S. A.; Lin, J.-R.; Rashid, R.; Yapp, C.; Ritch, C. C.; Khadka, P.; Regan, M.; Hwang, J.; Wen, P. Y.; Bandopadhayay, P.; Ligon, K. L.; Agar, N. Y.; Sorger, P. K.; Touat, M.; Santagata, S.

10.1101/2022.01.12.475925 — cancer biology — Posted on 2022-01-12

2478 MT-MAG: Accurate and interpretable machine learning based taxonomic assignment of metagenome-assembled genomes, with a partial classification option

Li, W.; Kari, L.; Yu, Y.; Hug, L. A.

10.1101/2022.01.12.475159 — bioinformatics — Posted on 2022-01-12

2479 GNN-SubNet: disease subnetwork detection with explainable Graph Neural Networks

Pfeifer, B.; Secic, A.; Saranti, A.; Holzinger, A.

10.1101/2022.01.12.475995 — bioinformatics — Posted on 2022-01-12

2480 Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster

Johnstone, P. S.; Ogueta, M.; Top, I.; Syed, S.; Stanewsky, R.; Top, D.

10.1101/2022.01.12.476067 — genetics — Posted on 2022-01-12

2481 Temperature-dependent genetics of thermotolerance between yeast species

Abrams, M. B.; Brem, R. B.

10.1101/2022.01.11.475859 — evolutionary biology — Posted on 2022-01-12

2482 Sex-specific evolution of a Drosophila sensory system via interacting cis- and trans-regulatory changes

Luecke, D. M.; Rice, G. R.; Kopp, A.

10.1101/2022.01.12.475924 — evolutionary biology — Posted on 2022-01-12

2483 Estimating alpha, beta, and gamma diversity through deep learning

Andermann, T.; Antonelli, A.; Barrett, R.; Silvestro, D.

10.1101/2022.01.12.475997 — evolutionary biology — Posted on 2022-01-12

2484 A comparative study of cellular diversity between the Xenopus pronephric and mouse metanephric nephron

Corkins, M. E.; Achieng, M.; DeLay, B. D.; Stankic, V.; Cain, M. P.; Walker, B. L.; Chen, J.; Lindstrom, N. O.; Miller, R. K.

10.1101/2022.01.11.475739 — evolutionary biology — Posted on 2022-01-12

2485 A framework for the quantification of soundscape diversity using Hill numbers

Luypaert, T.; Bueno, A. S.; Masseli, G. S.; Kaefer, I. L.; Campos-Cerqueira, M.; Peres, C. A.; Haugaasen, T.

10.1101/2022.01.11.475919 — ecology — Posted on 2022-01-12

2486 rescomp: An R package for defining, simulating and visualizing ODE models of consumer-resource interactions

Letten, A. D.

10.1101/2022.01.11.475574 — ecology — Posted on 2022-01-12

2487 Improved biodiversity detection using a large-volume environmental DNA sampler with in situ filtration and implications for marine eDNA sampling strategies

Govindarajan, A. F.; McCartin, L.; Adams, A.; Allan, E.; Belani, A.; Francolini, R.; Fujii, J.; Gomez-Ibanez, D.; Kukulya, A.; Marin, F.; Tradd, K.; Yoerger, D. R.; McDermott, J. M.; Herrera, S.

10.1101/2022.01.12.475892 — ecology — Posted on 2022-01-12

2488 Negative feedback may suppress variation to improve collective foraging performance

Reina, A.; Marshall, J. A. R.

10.1101/2020.04.21.053074 — ecology — Posted on 2022-01-12

2489 The Mechanisms of GPR55 Receptor Functonal Selectivity

Akimov, M. G.; Gretskaya, N. M.; Dudina, P. V.; Sherstyanykh, G.; Zinchenko, G. N.; Serova, O. V.; Degtyaryova, K. O.; Deyev, I. E.; Bezuglov, V. V.

10.1101/2022.01.12.476071 — cell biology — Posted on 2022-01-12

2490 Quantitative live-cell fluorescence imaging of GPCR downstream signaling dynamics at the single-cell level.

Tany, R.; Goto, Y.; Kondo, Y.; Aoki, K.

10.1101/2021.08.22.457285 — cell biology — Posted on 2022-01-12

2491 Basal Gp78 mitophagy promotes mitochondrial health and limits mitochondrial ROS production

Alan, P.; Vandevoorde, K. R.; Joshi, B.; Cardoen, B.; Gao, G.; Mohammadzadeh, Y.; Hamarneh, G.; Nabi, I. R.

10.1101/2021.09.17.460825 — cell biology — Posted on 2022-01-12

2492 Fission yeast polycystin Pkd2p promotes the cell expansion and antagonizes the Hippo pathway SIN

Sinha, D.; Ivan, D.; Gibbs, E.; Chetluru, M.; Goss, J. W.; Chen, Q.

10.1101/2021.05.21.444707 — cell biology — Posted on 2022-01-12

2493 Pathogenic, but not non-pathogenic, Rickettsia evade inflammasome-dependent IL-1 responses to establish an intracytosolic replication niche.

Voss, O. H.; Cobb, J.; Gaytan, H.; Rivera Diaz, N.; Sanchez, R.; DeTolla, L.; Rahman, M. S.; Azad, A. F.

10.1101/2021.09.08.459437 — microbiology — Posted on 2022-01-12

2494 Propofol anesthesia alters cortical traveling waves

Bhattacharya, S.; Donoghue, J. A.; Mahnke, M.; Brincat, S. L.; Brown, E. N.; Miller, E. K.

10.1101/2022.01.11.475912 — neuroscience — Posted on 2022-01-12

2495 Mid-level feature differences underlie early animacy and object size distinctions: Evidence from EEG decoding

Wang, R.; Janini, D.; Konkle, T.

10.1101/2022.01.12.475180 — neuroscience — Posted on 2022-01-12

2496 Hippocampal protein aggregation signatures fully distinguish pathogenic and wildtype UBQLN2 in amyotrophic lateral sclerosis

Thumbadoo, K. M.; Dieriks, B. V.; Murray, H. C.; Swanson, M. E.; Yoo, J. H.; Mehrabi, N. F.; Turner, C.; Dragunow, M.; Faull, R. L.; Curtis, M. A.; Siddique, T.; Shaw, C. E.; Henden, L.; Williams, K. L.; Nicholson, G. A.; Scotter, E. L.

10.1101/2022.01.12.475792 — neuroscience — Posted on 2022-01-12

2497 Parallel processing in speech perception with local and global representations of linguistic context

Brodbeck, C.; Bhattasali, S.; Cruz Heredia, A. A. L.; Resnik, P.; Simon, J. Z.; Lau, E.

10.1101/2021.07.03.450698 — neuroscience — Posted on 2022-01-12

2498 Hippocampal Transplants of Fetal GABAergic Progenitors Regulate Adult Neurogenesis in Mice with Temporal Lobe Epilepsy

Arshad, M. N.; Oppenheimer, S.; Jeong, J.; Buyukdemirtas, B.; Naegele, J. R.

10.1101/2022.01.11.475674 — neuroscience — Posted on 2022-01-12

2499 Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells

Canton-Josh, J. E.; Qin, J.; Salvo, J.; Kozorovitskiy, Y.

10.1101/2021.03.26.437266 — neuroscience — Posted on 2022-01-12

2500 Hydrodynamic and Polyelectrolyte Properties of Actin Filaments: Theory and Experiments

Alva Sevilla, E.; George, A.; Brancaleon, L.; Marucho, M.

10.1101/2022.01.11.475973 — neuroscience — Posted on 2022-01-12

2501 How salience enhances inhibitory control: An analysis of electro-cortical mechanisms

Kenemans, J. L.; Schutte, I.; Van Bijnen, S.; Logemann, H. N. A.

10.1101/2022.01.12.475991 — neuroscience — Posted on 2022-01-12

2502 Mapping electromagnetic networks to haemodynamic networks in the human brain

Shafiei, G.; Baillet, S.; Misic, B.

10.1101/2021.09.07.458941 — neuroscience — Posted on 2022-01-12

2503 What can astrocytes compute?

Peterson, E. J.

10.1101/2021.10.20.465192 — neuroscience — Posted on 2022-01-12

2504 Error quantification in multi-parameter mapping facilitates robust estimation and enhanced group level sensitivity

Mohammadi, S.; Streubel, T.; Klock, L.; Lutti, A.; Pine, K.; Weber, S.; Edwards, L.; Scheibe, P.; Ziegler, G.; Gallinat, J.; Kuhn, S.; Callaghan, M.; Weiskopf, N.; Tabelow, K.

10.1101/2022.01.11.475846 — neuroscience — Posted on 2022-01-12

2505 Chemogenetic inhibition of a monosynaptic projection from the basolateral amygdala to the ventral hippocampus reduces appetitive and consummatory alcohol drinking behaviors

Bach, E. C.; Ewin, S. E.; Heaney, C. F.; Carlson, H. N.; Almonte, A. G.; Chappell, A. M.; Raab-Graham, K. F.; Weiner, J. L.

10.1101/529719 — neuroscience — Posted on 2022-01-12

2506 Motor cortical output for skilled forelimb movement is selectively distributed across projection neuron classes

Park, J.; Phillips, J. A.; Guo, J.-Z.; Martin, K. A.; Hantman, A. W.; Dudman, J. T.

10.1101/772517 — neuroscience — Posted on 2022-01-12

2507 Efficient enrichment of synchronized mouse spermatocytes suitable for genome-wide analysis.

Carbajal, A.; Gryniuk, I.; de Castro, R.; Pezza, R.

10.1101/2022.01.11.475957 — systems biology — Posted on 2022-01-12

2508 Repeated toxic injuries of murine liver are tolerated through microsteatosis and mild inflammation

Hammad, S.; Ogris, C.; Othman, A.; Erdoesi, P.; Schmidt-Heck, W.; Biermayer, I.; Helm, B.; Gao, Y.; Pioronska, W.; D'Alessandro, L. A.; Theis, F.; Ebert, M. P.; Klingmüller, U. J.; Hengstler, J.; Dooley, S.; Mueller, N.

10.1101/2022.01.12.476054 — systems biology — Posted on 2022-01-12

2509 Cost-effectiveness of quadrivalent versus trivalent inactivated influenza vaccines for the Portuguese elderly population

Tavares, D.; Mourino, H.; Rodriguez, C. A.; Saborido, C. M.

10.1101/2022.01.04.474923 — scientific communication and education — Posted on 2022-01-12

2510 Phenotypic and transcriptomic analysis reveals early stress responses in transgenic rice expressing Arabidopsis DREB1a

Berchembrock, Y. V.; Pathak, B.; Maurya, C.; Botelho, F. B.; Srivastava, V.

10.1101/2022.01.12.475916 — plant biology — Posted on 2022-01-12

2511 Oncogenic role of a developmentally regulated NTRK2 splice variant

Pattwell, S. S.; Arora, S.; Nuechterlein, N.; Zager, M.; Loeb, K. R.; Cimino, P. J.; Holland, N. C.; Reche-Ley, N.; Bolouri, H.; Bonin, D. A. A.; Szulzewsky, F.; Phadnis, V. V.; Ozawa, T.; Wagner, M. J.; Haffner, M. C.; Cao, J.; Shendure, J.; Holland, E. C.

10.1101/2022.01.07.475392 — cancer biology — Posted on 2022-01-12

2512 Targeting MLL methyltransferases enhance the anti-tumor effects of PI3K inhibition in hormone receptor-positive breast cancer

Jones, R. B.; Farhi, J.; Adams, M.; Parwani, K.; Zecevic, M.; Cooper, G.; Lee, R. S.; Hong, A. L.; Spangle, J.

10.1101/2021.10.01.462826 — cancer biology — Posted on 2022-01-12

2513 Mechanical characterisation of the developing cell wall layers of tension wood fibres by Atomic Force Microscopy

Arnould, O.; Capron, M.; Ramonda, M.; Laurans, F.; Almeras, T.; Pilate, G.; Clair, B.

10.1101/2021.09.23.461481 — biophysics — Posted on 2022-01-12

2514 Comparing the folding landscapes of evolutionarily divergent procaspase-3

Yao, L.; Clark, C.

10.1101/2022.01.12.476064 — biophysics — Posted on 2022-01-12

2515 Reproduction in deep-sea vent shrimps is shaped by diet and phylogeny, with rhythms unlinked to surface production

Methou, P.; Chen, C.; Watanabe, H. K.; Cambon-Bonavita, M.-A.; Pradillon, F.

10.1101/2021.09.10.456763 — ecology — Posted on 2022-01-12

2516 Full Spectrum Flow Cytometry for High-Dimensional Immunophenotyping of Mouse Innate Lymphoid Cells

Mincham, K. T.; Snelgrove, R. J.

10.1101/2022.01.05.475054 — cell biology — Posted on 2022-01-12

2517 Cave Thiovulaceae differ metabolically and genomically from marine species

Bizic, M.; Brad, T.; Ionescu, D.; Barbu-Tudoran, L.; Aerts, J.; Popa, R.; Zoccarato, L.; Ody, J.; Flot, J.-F.; Tighe, S.; Vellone, D.; Sarbu, S. M.

10.1101/2020.11.04.367730 — microbiology — Posted on 2022-01-12

2518 Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1

Mudgal, R.; Bharadwaj, C.; Dubey, A.; Choudhary, S.; Nagarajan, P.; Aggarwal, M.; Ratra, Y.; Basak, S.; Tomar, S.

10.1101/2021.08.19.457046 — immunology — Posted on 2022-01-12

2519 Strong Aversive Conditioning Triggers a Long-Lasting Generalized Aversion

Ramos, R.; Wu, C.-H.; Turrigiano, G. G.

10.1101/2022.01.10.475691 — neuroscience — Posted on 2022-01-12

2520 Efficient generation of lower induced Motor Neurons by coupling Ngn2 expression with developmental cues

Limone, F.; Mitchell, J. M.; Guerra San Juan, I.; Smith, J. L. M.; Raghunathan, K.; Couto, A.; Ghosh, S. D.; Meyer, D.; Mello, C. J.; Nemesh, J.; Smith, B. M.; McCarroll, S. A.; Pietiläinen, O.; Nehme, R.; Eggan, K.

10.1101/2022.01.12.476020 — neuroscience — Posted on 2022-01-12

2521 Istaroxime metabolite PST3093 selectively stimulates SERCA2a and reverses disease-induced changes in cardiac function

Arici, M.; Ferrandi, M.; Barassi, P.; Hsu, S.-C.; Torre, E.; Luraghi, A.; Ronchi, C.; Chang, G.-J.; Peri, F.; Ferrari, P.; Bianchi, G.; Rocchetti, M.; Zaza, A.

10.1101/2021.08.17.455204 — pharmacology and toxicology — Posted on 2022-01-12

2522 Combining ultra-high-field fMRI adaptation and computational modelling to estimate neuronal frequency selectivity in human auditory cortex

Besle, J.; Sanchez-Panchuelo, R.-M.; Francis, S.; Krumbholz, K.

10.1101/2022.01.06.475208 — neuroscience — Posted on 2022-01-12

2523 HIV and FIV glycoproteins increase cellular tau pathology via cGMP-dependent kinase II activation

Sathler, M. F.; Doolittle, M. J.; Cockrell, J. A.; Nadalin, I. R.; Hofmann, F.; VandeWoude, S.; Kim, S.

10.1101/2022.01.11.475910 — neuroscience — Posted on 2022-01-12

2524 Sex differences in pain-related behaviors and clinical progression of disease in mouse models of visceral pain

Francis-Malave, A. M.; Martinez Gonzalez, S.; Pichardo, C.; Wilson, T. D.; Rivera, L. G.; Brinster, L. R.; Carrasquillo, Y.

10.1101/2022.01.11.475721 — neuroscience — Posted on 2022-01-12

2525 Machine-learning from Pseudomonas putida transcriptomes reveals its transcriptional regulatory network

Lim, H. G.; Rychel, K.; Sastry, A. V.; Mueller, J.; Niu, W.; Feist, A. M.; Palsson, B. O.

10.1101/2022.01.11.475908 — systems biology — Posted on 2022-01-12

2526 A split ribozyme that links detection of a native RNA to orthogonal protein outputs

Gambill, L.; Staubus, A.; Ameruoso, A.; Chappell, J.

10.1101/2022.01.12.476080 — synthetic biology — Posted on 2022-01-12

2527 Machine Learning-Based Enzyme Engineering of PETase for Improved Efficiency in Degrading Non-Biodegradable Plastic

Gupta, A.; Agrawal, S.

10.1101/2022.01.11.475766 — synthetic biology — Posted on 2022-01-12

2528 BECN1 F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner

Sebti, S.; Zou, Z.; Shiloh, M. U.

10.1101/2022.01.12.475960 — physiology — Posted on 2022-01-12

2529 Favipiravir, umifenovir and camostat mesylate: a comparative study against SARS-CoV-2

Unal, M. A.; Besbinar, O.; Nazir, H.; Summak, G. Y.; Bayrakdar, F.; Delogu, L. G.; Taskin, T.; Ozkan, S. A.; Akcali, K. C.; Yilmazer, A.

10.1101/2022.01.11.475889 — pharmacology and toxicology — Posted on 2022-01-12

2530 Tissue fibroblasts are a critical source of prostacyclin and anti-thrombotic

Mitchell, J. A.; Vinokurova, M.; Lopes-Pires, M. E.; Shala, F.; Armstrong, P. C.; Ahmetaj-Shala, B.; Elghazouli, Y.; Liu, B.; Zhou, Y.; Hao, C.; Herschman, H.; Kirkby, N. S.

10.1101/2022.01.11.475814 — pharmacology and toxicology — Posted on 2022-01-12

2531 Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein

Fernandes, M. F.; Chan, J. Z.; Hung, C. C. J.; Tomczewski, M. V.; Duncan, R. E.

10.1101/2022.01.11.475901 — pharmacology and toxicology — Posted on 2022-01-12

2532 Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence

Toghani, D.; Zeng, S.; Mahammadov, E.; Crosse, E. I.; Seyedhassantehrani, N.; Burns, C.; Gravano, D.; Radtke, S.; Kiem, H.-P.; Rodriguez, S.; Carlesso, N.; Pradeep, A.; Wilson, N. K.; Kinston, S. J.; Gottgens, B.; Nerlov, C.; Pietras, E.; Mesnieres, M.; Maes, C.; Kumanogoh, A.; Worzfeld, T.; Kharchenko, P.; Scialdone, A.; Spencer, J. A.; Silberstein, L.

10.1101/2022.01.12.476097 — cell biology — Posted on 2022-01-12

2533 Cell adhesion and immune response, two main functions altered in the transcriptome of seasonally regressed testes of two mammalian species

Real, F. M.; Lao-Perez, M.; Burgos, M.; Mundlos, S.; Lupianez, D. G.; Jimenez, R.; Barrionuevo, F. J.

10.1101/2022.01.12.476048 — molecular biology — Posted on 2022-01-12

2534 Hemagglutinin stability determines influenza A virus susceptibility to a broad-spectrum fusion inhibitor Arbidol

Li, Z.; Li, T.; Liu, M.; Ivanovic, T.

10.1101/2022.01.11.475941 — microbiology — Posted on 2022-01-12

2535 GR13-type plasmids in Acinetobacter potentiate the accumulation and horizontal transfer of diverse accessory genes

Moran, R. A.; Liu, H.; Doughty, E. L.; Hua, X.; Cummins, E. A.; Liveikis, T.; McNally, A.; Zhou, Z.; van Schaik, W.; Yu, Y.

10.1101/2022.01.12.475240 — microbiology — Posted on 2022-01-12

2536 A Longitudinal Study of Dominant E. coli Lineages and Antimicrobial Resistance in the Gut of Children Living in an Upper Middle-income Country

Trueba, G.; Calderon, D.; Cardenas, P. A.; Prado, M. B.; Graham, J.

10.1101/2022.01.11.475974 — microbiology — Posted on 2022-01-12

2537 Maternally transferred monoclonal antibodies protect neonatal mice from herpes simplex virus-induced mortality and morbidity

Backes, I. M.; Byrd, B. K.; Patel, C. D.; Taylor, S. A.; Garland, C. R.; MacDonald, S. W.; Balazs, A. B.; Davis, S. C.; Ackerman, M. E.; Leib, D. A.

10.1101/2022.01.12.476098 — immunology — Posted on 2022-01-12

2538 Potentiation of drug toxicity through virus latency reversal promotes preferential elimination of HIV infected cells

Truong, T.; Hayn, M.; Kaas Frich, C.; Ladefoged, L. K.; Jarlstad Olesen, M.; Jakobsen, J.; Lunaberg, C.; Schiott, B.; Muench, J.; Zelikin, A. N.

10.1101/2022.01.12.476003 — pharmacology and toxicology — Posted on 2022-01-12

2539 Collaborative workflow between pathologists and deep learning for evaluation of tumor cellularity in lung adenocarcinoma

Sakamoto, T.; Furukawa, T.; Pham, H. H. N.; Kuroda, K.; Tabata, K.; Kashima, Y.; Okoshi, E. N.; Morimoto, S.; Bychkov, A.; Fukuoka, J.

10.1101/2022.01.11.475587 — pathology — Posted on 2022-01-12

2540 Skeletal muscle regeneration is altered in the R6/2 mouse model of Huntington's disease

Hoque, S.; Sjogren, M.; Allamand, V.; Gawlik, K.; Franke, N.; Durbeej, M.; Bjorkqvist, M.; Soylu-Kucharz, R.

10.1101/2022.01.11.475914 — pathology — Posted on 2022-01-12

2541 Reciprocal epigenetic Sox2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer

SHONIBARE, Z.; Monavarian, M.; O'Connell, K.; Altomare, D.; Shelton, A. K.; Mehta, S.; Jaskula-Sztul, R.; Phaeton, R.; Starr, M. D.; Whitaker, R.; Berchuck, A.; Nixon, A.; Arend, R. C.; Lee, N. Y.; Miller, C. R.; Hempel, N.; Mythreye, K.

10.1101/2022.01.11.475900 — cancer biology — Posted on 2022-01-12

2542 Lightweight compositional analysis of metagenomes with FracMinHash and minimum metagenome covers

Irber, L. C.; Brooks, P. T.; Reiter, T. E.; Pierce-Ward, N. T.; Hera, M. R.; Koslicki, D.; Brown, C. T.

10.1101/2022.01.11.475838 — bioinformatics — Posted on 2022-01-12

2543 Debiasing FracMinHash and deriving confidence intervals for mutation rates across a wide range of evolutionary distances

Rahman Hera, M.; Pierce-Ward, N. T.; Koslicki, D.

10.1101/2022.01.11.475870 — bioinformatics — Posted on 2022-01-12

2544 The channel activities of the full-length prion and truncated proteins

Wu, J.; Lakkaraju, A. K.; Aguzzi, A. K.; Luo, J.

10.1101/2022.01.12.475988 — biochemistry — Posted on 2022-01-12

2545 Factor VII activating protease (FSAP) inhibits the outcome of ischemic stroke in mouse models.

Kim, J.-Y.; Manna, D.; Leergaard, T. B.; Kanse, S. M.

10.1101/2022.01.12.476006 — biochemistry — Posted on 2022-01-12

2546 Cross-linking of the Endolysosomal System Reveals Flotillin Structures and Putative Cargo

Singh, J.; Elhabashy, H.; Muthukottiappan, P.; Stepath, M.; Eisenacher, M.; Kohlbacher, O.; Gieselmann, V.; Winter, D.

10.1101/2022.01.12.475930 — biochemistry — Posted on 2022-01-12

2547 Structural and functional impact by SARS-CoV-2 Omicron spike mutations

Zhang, J.; Cai, Y.; Lavine, C.; Peng, H.; Zhu, H.; Anand, K.; Tong, P.; Gautam, A.; Mayer, M.; Rits-Volloch, S.; Wang, S.; Sliz, P.; Wesemann, D.; Yang, W.; Seaman, M.; Lu, J.; Xiao, T.; Chen, B.

10.1101/2022.01.11.475922 — biochemistry — Posted on 2022-01-12

2548 A bacterial secretosome for regulated envelope biogenesis and quality control

Watkins, D. W.; Collinson, I.

10.1101/2022.01.12.476021 — biochemistry — Posted on 2022-01-12

2549 A survey on antimicrobial resistance genes of frequently used bacteria in kefir and yoghurt

Judge, M. F.; Toth, A. G.; Nagy, S. A.; Papp, M.; Solymosi, N.

10.1101/2022.01.12.476061 — genomics — Posted on 2022-01-12

2550 Two modes of evolution shape bacterial strain diversity in the gut for thousands of generations

Frazao, N.; Konrad, A.; Güleresi, D.; Lässig, M.; Gordo, I.

10.1101/2022.01.11.475860 — evolutionary biology — Posted on 2022-01-12

2551 Evolution under juvenile malnutrition impacts adult metabolism and fitness

Erkosar, B.; Dupuis, C.; Cavigliasso, F.; Savary, L.; Gallart-Ayala, H.; Ivanisevic, J.; Kawecki, T. J.

10.1101/2022.01.11.475896 — evolutionary biology — Posted on 2022-01-12

2552 Ablation of SAMD1 in Mice Causes Failure of Angiogenesis, Embryonic Lethality

Campbell, B.; Engle, S.; Bourassa, P.; Aiello, R.

10.1101/2022.01.11.473462 — developmental biology — Posted on 2022-01-12

2553 Geometric control of Myosin-II orientation during axis elongation

Lefebvre, M. F.; Claussen, N. H.; Mitchell, N. P.; Gustafson, H. J.; Streichan, S. J.

10.1101/2022.01.12.476069 — developmental biology — Posted on 2022-01-12

2554 cdon and boc affect trunk neural crest cell migration through a non-cell autonomous reduction of hedgehog signaling in zebrafish slow-twitch muscle

Lencer, E.; Prekeris, R.; Artinger, K.

10.1101/2022.01.10.475733 — developmental biology — Posted on 2022-01-12

2555 Epac1 regulates cellular SUMOylation by promoting the formation of SUMO-activating nuclear condensates

Yang, W.; Robichaux, W. G.; Mei, F. C.; Lin, W.; Li, L.; Pan, S.; White, M. A.; Chen, Y.; Cheng, X.

10.1101/2022.01.12.476066 — cell biology — Posted on 2022-01-12

2556 Comparison of double-stranded and single-stranded cfDNA library construction methods for targeted genome and methylation sequencing

Zheng, J.; Li, Z.; Zhang, X.; Zhang, H.; Zhu, S.; Sun, J.; Wang, Y.

10.1101/2022.01.12.475986 — molecular biology — Posted on 2022-01-12

2557 Vitamin C functions as double-edge sword on cancer progression depending on ERK activation or inhibition mediated by its receptor SVCT2

Guan, Y.; Chen, B.; Wu, Y.; Han, Z.; Xu, H.; Zhang, C.; Hao, W.; Gao, W.; Guo, Z.

10.1101/2022.01.11.475954 — molecular biology — Posted on 2022-01-12

2558 Generation and characterisation of P. falciparum parasites with a G358S mutation in the PfATP4 Na+ pump and clinically relevant levels of resistance to some PfATP4 inhibitors

Qiu, D.; Pei, J. V.; Rosling, J. E. O.; Li, D.; Xue, Y.; Penington, J. S.; Kümpornsin, K.; Aw, Y. T. V.; Aw, J. Y. H.; Hasemer, H.; Dennis, A. S. M.; Ridgway, M. C.; Papenfuss, A. T.; Lee, M. C. S.; van Dooren, G. G.; Kirk, K.; Lehane, A. M.

10.1101/2022.01.11.475938 — microbiology — Posted on 2022-01-12

2559 Systemic infection of SARS-CoV-2 in free ranging Leopard (Panthera pardus fusca) in India

Mahajan, S.; Mathesh, K.; Chander, V.; Pawde, A. M.; Saikumar, G.; Semmaran, M.; Sree lakshmi, P.; Sharma, M.; nandi, S.; Singh, K. P.; Gupta, V. K.; Singh, R. K.; Sharma, G.

10.1101/2022.01.11.475327 — microbiology — Posted on 2022-01-12

2560 Evolution of a cis-acting SNP that controls Type VI Secretion in Vibrio cholerae

Ng, S. L.; Kammann, S. A.; Steinbach, G.; Hoffmann, T.; Yunker, P. J.; Hammer, B. K.

10.1101/2022.01.11.475911 — microbiology — Posted on 2022-01-12

2561 RNA-based therapy for Cryptosporidium parvum infection: proof-of-concept studies

Castellanos-Gonzalez, A.; Sadiqova, A.; Ortega-Mendez, J.; White, A. C.

10.1101/2022.01.11.475978 — microbiology — Posted on 2022-01-12

2562 Localized Cardiolipin Synthesis is Required for the Assembly of MreB During the Polarized Cell Division of Chlamydia trachomatis

Ouellette, S. P.; Fisher-Marvin, L. A.; Harpring, M.; Lee, J.; Rucks, E. A.; Cox, J. V.

10.1101/2022.01.12.476008 — microbiology — Posted on 2022-01-12

2563 "Learning in reverse: Dopamine errors drive excitatory and inhibitory components of backward conditioning in an outcome-specific manner".

Seitz, B. M.; Hoang, I. B.; Blaisdell, A. P.; Sharpe, M. J.

10.1101/2022.01.10.475719 — neuroscience — Posted on 2022-01-12

2564 SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike-ACE2 receptor interaction

Albornoz, E. A.; Amarilla, A. A.; Modhiran, N.; Parker, S.; Li, X. X.; Wijesundara, D. K.; Pliego Zamora, A.; McMillan, C. L.; Liang, B.; Peng, N. Y. G.; Sng, J. D. J.; Tuj Saima, F.; Paramitha, D.; Parry, R.; Avumegah, M. S.; Isaacs, A.; Lo, M.; Miranda-Chacon, Z.; Bradshaw, D.; Salinas-Rebolledo, C.; Rajapakse, N. W.; Munro, T.; Rojas-Fernandez, A.; Young, P. R.; Stacey, K. J.; Khromykh, A. A.; Chappell, K. J.; Watterson, D.; Woodruff, T. M.

10.1101/2022.01.11.475947 — neuroscience — Posted on 2022-01-12

2565 Optimization of an unscented Kalman filter for an embedded platform

Graybill, P. P.; Gluckman, B. J.; Kiani, M.

10.1101/2022.01.11.475885 — neuroscience — Posted on 2022-01-12

2566 Pathological relevance of post-translationally modified alpha-synuclein (pSer87, pSer129, nTyr39) in idiopathic Parkinson's disease and Multiple System Atrophy.

Sonustun, B.; Altay, F. M.; Strand, C.; Hondhamuni, G.; Warner, T. T.; Lashuel, H. A.; Bandopadhyay, R.

10.1101/2022.01.11.475823 — neuroscience — Posted on 2022-01-12

2567 Optimal protein production by a synthetic microbial consortium: Coexistence, distribution of labor, and syntrophy

Martinez, C.; Cinquemani, E.; de Jong, H.; Gouze, J.-L.

10.1101/2022.01.12.476046 — synthetic biology — Posted on 2022-01-12

2568 Sri Lankan Footprint in Global Aquatic Science Research: A Scientometric Analysis

Bandara, T.

10.1101/2022.01.11.475849 — scientific communication and education — Posted on 2022-01-12

2569 High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake in young men independently of changes in thermogenesis and the gut microbiome

Richard, G.; Blondin, D. P.; Syed, S. A.; Rossi, L.; Fontes, M. E.; Fortin, M.; Phoenix, S.; Frisch, F.; Dubreuil, S.; Guérin, B.; Turcotte, Éric E.; Lepage, M.; Surette, M. G.; Schertzer, J. D.; Steinberg, G. R.; Morrison, K. M.; Carpentier, A. C.

10.1101/2022.01.11.475847 — physiology — Posted on 2022-01-12

2570 Transitivity scores to account for triadic edge weight similarity in undirected weighted graphs

Peron, G.

10.1101/2022.01.11.475816 — bioinformatics — Posted on 2022-01-12

2571 De novo protein structure prediction by incremental inter-residue geometries prediction and model quality assessment using deep learning

Liu, J.; He, G.; Zhao, K.; Zhang, G.

10.1101/2022.01.11.475831 — bioinformatics — Posted on 2022-01-12

2572 Considering decoupled phenotypic diversification between ontogenetic phases in macroevolution: An example using Triggerfishes (Balistidae)

Dornburg, A.; Zapfe, K.; Williams, R.; Alfaro, M.; Morris, R.; Adachi, H.; Flores, J.; Santini, F.; Near, T.; Frederich, B.

10.1101/2022.01.11.475856 — evolutionary biology — Posted on 2022-01-12

2573 Background selection theory overestimates effective population size for high mutation rates

Matheson, J. D.; Masel, J.

10.1101/2022.01.11.475913 — evolutionary biology — Posted on 2022-01-12

2574 Teasing apart the joint effect of demography and natural selection in the birth of a contact zone

Li, L.; Milesi, P.; Tiret, M.; Chen, J.; Sendrowski, J.; Baison, J.; Chen, Z.-q.; Zhou, L.; Karlsson, B.; Berlin, M.; Westin, J.; Garcia-Gil, M. R.; Wu, H.; Lascoux, M.

10.1101/2022.01.11.475794 — evolutionary biology — Posted on 2022-01-12

2575 Loss of plastid developmental genes coincides with a reversion to monoplastidy in hornworts

MacLeod, A. I.; Raval, P. K.; Stockhorst, S.; Knopp, M.; Frangedakis, E.; Gould, S. B.

10.1101/2022.01.11.475830 — evolutionary biology — Posted on 2022-01-12

2576 Aedes aegypti and Aedes albopictus abundance, landscape coverage and spectral indices effects in a subtropical city of Argentina

Martin, M. E.; Alonso, A. C.; Faraone, J.; Stein, M.; Estallo, E. L.

10.1101/2022.01.11.475665 — ecology — Posted on 2022-01-12

2577 In vivo imaging of calcium dynamics in zebrafish hepatocytes

Pozo-Morales, M.; Garteizgogeascoa, I.; Perazzolo, C.; Singh, S. P.

10.1101/2022.01.11.475536 — developmental biology — Posted on 2022-01-12

2578 Differentiation of a CD4+/CD8αβ+ Double Positive T Cell Population From The CD8 Pool Is Sufficient To Mediate Graft-vs-Host Disease but not Graft-vs-Leukemia Effects

Hess, N. J.; Turicek, D. P.; Nadiminti, K.; Hudson, A.; Hematti, P.; Gumperz, J. E.; Capitini, C. M.

10.1101/2022.01.11.475845 — immunology — Posted on 2022-01-12

2579 Corrective feedback control of competing neural network with entire connections

Wang, U.

10.1101/2022.01.10.475737 — neuroscience — Posted on 2022-01-12

2580 Hebbian activity-dependent plasticity in white matter

Lazari, A.; Salvan, P.; Cottaar, M.; Papp, D.; Rushworth, M. F.; Johansen-Berg, H.

10.1101/2022.01.11.473633 — neuroscience — Posted on 2022-01-12

2581 FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis

Jonnalagadda, D.; Kihara, Y.; Groves, A.; Ray, M.; Saha, A.; Lee-Okada, H.-C.; Furihata, T.; Yokomizo, T.; Quadros, E. V.; Rivera, R.; Chun, J.

10.1101/2022.01.10.475450 — neuroscience — Posted on 2022-01-12

2582 Cd59 and inflammation orchestrate Schwann cell development

Wiltbank, A. T.; Steisnon, E.; Criswell, S. J.; Piller, M.; Kucenas, S.

10.1101/2022.01.11.475853 — neuroscience — Posted on 2022-01-12

2583 Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus

Barbuskaite, D.; Oernbo, E. K.; Wardman, J. H.; Toft-Bertelsen, T. L.; Conti, E.; Andreassen, S. N.; Gerkau, N.; Rose, C. R.; MacAulay, N.

10.1101/2022.01.11.475854 — neuroscience — Posted on 2022-01-12

2584 Brain responses in aggression-prone individuals: A systematic review and meta-analysis of functional magnetic resonance imaging (fMRI) studies of anger- and aggression-eliciting tasks

Nikolic, M.; Pezzoli, P.; Jaworska, N.; Seto, M. C.

10.1101/2022.01.11.475895 — neuroscience — Posted on 2022-01-12

2585 Panoramic visual statistics shape retina-wide organization of receptive fields

Gupta, D.; Mlynarski, W.; Symonova, O.; Svaton, J.; Joesch, M.

10.1101/2022.01.11.475815 — neuroscience — Posted on 2022-01-12

2586 NNeurite: artificial neuronal networks for the unsupervised extraction of axonal and dendritic time-lapse signals

Chenouard, N.; Kouskoff, V.; Tsien, R. W.; Gambino, F.

10.1101/2022.01.11.475549 — neuroscience — Posted on 2022-01-12

2587 Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome

Unda, B. K.; Chalil, L.; Yoon, S.; Kilpatrick, S.; Xing, S.; Murtaza, N.; Cheng, A.; Afonso, A.; McCready, E.; Ronen, G.; Howe, J.; Caye-Eude, A.; Verloes, A.; Doble, B. W.; Faivre, L.; Vitobello, A.; Lu, Y.; Penzes, P.; Scherer, S. W.; Singh, K. K.

10.1101/2022.01.11.475723 — neuroscience — Posted on 2022-01-12

2588 Foveal vision predictively sensitizes to defining features of eye movement targets

Kroell, L. M.; Rolfs, M.

10.1101/2022.01.11.475331 — neuroscience — Posted on 2022-01-12

2589 Uncovering potential interventions for pancreatic cancer patients via mathematical modeling

Plaugher, D. R.; Aguilar, B.; Murrugarra, D.

10.1101/2022.01.11.475711 — systems biology — Posted on 2022-01-12

2590 mTORC2 Drives ZFX-mediated Ganglioside Biosynthesis to Promote Breast Cancer Progression.

Rajput, K.; Ansari, M. N.; Jha, S. K.; Sharma, P.; Datta, S.; Medatwal, N.; Kar, A.; Pani, T.; Cholke, K.; Khan, A.; Mukherjee, G.; Deo, S.; Prabhu, J. S.; Mukhopadhyay, A.; Bajaj, A.; Dasgupta, U.

10.1101/2022.01.10.475595 — cancer biology — Posted on 2022-01-12

2591 Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks

Neyret-Kahn, H.; Fontugne, J.; Meng, X.-Y.; Groeneveld, C. S.; Cabel, L.; Ye, T.; Guyon, E.; Krucker, C.; Dufour, F.; Chapeaublanc, E.; Rapinat, A.; Jeffery, D. C. B.; Neuzillet, Y.; Lebret, T.; Gentien, D.; Davidson, I.; Allory, Y.; BERNARD-PIERROT, I.; Radvanyi, F.

10.1101/2022.01.11.475197 — cancer biology — Posted on 2022-01-12

2592 PEGPH20, a PEGylated Human Hyaluronidase, Induces Radiosensitization by Reoxygenation In Pancreatic Cancer Xenografts. A Molecular Imaging Study

Seki, T.; Saida, Y.; Kishimoto, S.; Lee, J.; Otowa, Y.; Yamamoto, K.; Chandramouli, G. V.; Devasahayam, N.; Mitchell, J. B.; Brender, J. R.; Krishna, M. C.

10.1101/2022.01.11.475894 — cancer biology — Posted on 2022-01-12

2593 ProtFinder: finding subcellular locations of proteins using protein interaction networks

Grover, A.; Gatto, L.

10.1101/2022.01.11.475836 — bioinformatics — Posted on 2022-01-12

2594 Inferring tumor-specific cancer dependencies through integrating ex-vivo drug response assays and drug-protein profiling

Batzilla, A.; Lu, J.; Kivioja, J.; Putzker, K.; Lewis, J.; Zenz, T.; Huber, W.

10.1101/2022.01.11.475864 — bioinformatics — Posted on 2022-01-12

2595 Predicting patient treatment response and resistance via single-cell transcriptomics of their tumors

Sinha, S.; vegesna, R.; Dhruba, S. R.; Wu, W.; Kerr, D. L.; Stroganov, O. V.; Grishagin, I.; Aldape, K. D.; Blakely, C. M.; Jiang, P.; Thomas, C. J.; Bivona, T. G.; Schaffer, A. A.; Ruppin, E.

10.1101/2022.01.11.475728 — bioinformatics — Posted on 2022-01-12

2596 Identifying and correcting repeat-calling errors in nanopore sequencing of telomeres

Tan, K.-T.; Slevin, M.; Meyerson, M.; Li, H.

10.1101/2022.01.11.475254 — bioinformatics — Posted on 2022-01-12

2597 GoPeaks: Histone Modification Peak Calling for CUT&Tag

Yashar, W. M.; Kong, G.; VanCampen, J.; Smith, B. M.; Coleman, D. J.; Carbone, L.; Yardimci, G. G.; Maxson, J. E.; Braun, T. P.

10.1101/2022.01.10.475735 — bioinformatics — Posted on 2022-01-12

2598 EagleImp: Fast and Accurate Genome-wide Phasing and Imputation in a Single Tool

Wienbrandt, L.; Ellinghaus, D.

10.1101/2022.01.11.475810 — bioinformatics — Posted on 2022-01-12

2599 Magnetic Temporal Interference for Noninvasive Focal Brain Stimulation

Khalifa, A.; Abrishami, S. M.; Zaeimbashi, M.; Tang, A. D.; Coughlin, B.; Rodger, J.; Sun, N.; Cash, S. S.

10.1101/2022.01.10.475762 — bioengineering — Posted on 2022-01-12

2600 Rational design yields molecular insights on leaf binding of the anchor peptide Macaque Histatin

Dittrich, J.; Brethauer, C.; Goncharenko, L.; Bührmann, J.; Zeisler-Diehl, V.; Pariyar, S.; Jakob, F.; Kurkina, T.; Schreiber, L.; Schwaneberg, U.; Gohlke, H.

10.1101/2022.01.11.475855 — bioengineering — Posted on 2022-01-12

2601 House sparrows do not exhibit a preference for the scent of potential partners with different MHC-I allele numbers and genetic distances

Amo, L.; Amo de Paz, G.; Kabbert, J.; Machordom, A.

10.1101/2022.01.11.475834 — animal behavior and cognition — Posted on 2022-01-12

2602 TEX13B is important for germ cell development and male fertility

Kumar, U.; Sudhakar, D. V. S.; Kumar, N.; Kale, H. T.; Jha, R. K.; Gupta, N. J.; Chakravarthy, B. N.; Deenadayal, M.; Tolani, A. D.; Raychaudhuri, S.; Shekar, P. C.; Thangaraj, K.

10.1101/2022.01.11.475851 — genetics — Posted on 2022-01-12

2603 Divergence and introgression among the virilis group of Drosophila

Yusuf, L.; Tyukmaeva, V.; Hoikkala, A.; Ritchie, M. G.

10.1101/2022.01.11.475832 — evolutionary biology — Posted on 2022-01-12

2604 Impact of Ghost Introgression on Coalescent-based Species Tree Inference and Estimation of Divergence Time

Pang, X.; Zhang, D.-Y.

10.1101/2022.01.11.475787 — evolutionary biology — Posted on 2022-01-12

2605 Consideration of genetic variation and evolutionary history in future conservation of Indian one-horned rhinoceros (Rhinoceros unicornis)

Ghosh, T.; Kumar, S.; Sharma, K.; Kakati, P.; Sharma, A.; Mondol, S.

10.1101/2022.01.11.475781 — ecology — Posted on 2022-01-12

2606 Detection of bifenthrin, bifenazate, etoxazole resistance in Tetranychus urticae collected from mint fields and hop yards using targeted sequencing and TaqMan approaches

Shumate, S.; Haylett, M.; Nelson, B.; Young, N.; Lamour, K.; Walsh, D.; Bradford, B. Z.; Clements, J.

10.1101/2022.01.10.475553 — ecology — Posted on 2022-01-12

2607 Global monitoring of soil animal communities using a common methodology

Potapov, A. M.; Sun, X.; Briones, M. J. I.; Brown, G.; Cameron, E.; Cortet, J.; Eisenhauer, N.; Fujii, S.; Geisen, S.; Gongalsky, K.; Guerra, C.; Handa, T.; Janion-Scheepers, C.; Lindo, Z.; Mathieu, J.; Murvanidze, M.; Nielsen, U. N.; Scheu, S.; Schmidt, O.; Schneider, C.; Seeber, J.; Tuma, J.; Tiunov, A.; Zaitsev, A.; Wall, D.

10.1101/2022.01.11.475793 — ecology — Posted on 2022-01-12

2608 Identification of Mfn2-S249 as a Phosphoregulatory Switch of Mitochondrial Fusion Dynamics

Kumar, S.; Ramonett, A.; Ahmed, T.; Kwak, E.; Flores, P. C.; Ortiz, H. R.; Langlais, P. R.; Karthikeyan, M.; Lee, N. Y.

10.1101/2022.01.11.475884 — cell biology — Posted on 2022-01-12

2609 Single-nucleus RNA-seq of normal-appearing brain regions in relapsing-remitting vs. secondary progressive multiple sclerosis

Kihara, Y.; Zhu, Y.; Jonnalagadda, D.; Romanow, W.; Palmer, C.; Siddoway, B.; Rivera, R.; Dutta, R.; Trapp, B. D.; Chun, J.

10.1101/2022.01.10.475705 — neuroscience — Posted on 2022-01-12

2610 Influence of data sampling methods on the representation of neural spiking activity in vivo

van der Heijden, M. E.; Brown, A. M.; Sillitoe, R. V.

10.1101/2022.01.11.475844 — neuroscience — Posted on 2022-01-12

2611 Failed remyelination of the non-human primate optic nerve leads to axon degeneration, retinal damages and visual dysfunction.

Sarrazin, N.; Chavret-Recculon, E.; Bachelin, C.; Felfli, M.; Arab, R.; Gilardeau, S.; Brazhnikova, E.; Dubus, E.; Yahia-Cherif, L.; Lorenceau, J.; Picaud, S.; Rosolen, S. G.; Moissonnier, P.; Pouget, P.; Baron-Van Evercooren, A.

10.1101/2022.01.11.475669 — neuroscience — Posted on 2022-01-12

2612 Astrogliosis mapping in individual brains using multidimensional MRI

Benjamini, D.; Priemer, D. S.; Perl, D. P.; brody, D. L.; Basser, P. J.

10.1101/2022.01.10.475717 — neuroscience — Posted on 2022-01-12

2613 Magnetic Stimulation Allows Focal Activation of the Mouse Cochlea

Lee, J.-I.; Seist, R.; McInturff, S.; Lee, D. J.; Brown, C.; Stankovic, K. M.; Fried, S.

10.1101/2022.01.11.475825 — neuroscience — Posted on 2022-01-12

2614 40 new specimens of Ichthyornis provide unprecedented insight into the postcranial morphology of crownward stem group birds.

Benito, J.; Chen, A.; Wilson, L. E.; Bhullar, B.-A. S.; Burnham, D.; Field, D. J.

10.1101/2022.01.11.475364 — paleontology — Posted on 2022-01-12

2615 Elevated FAM84B promotes cell proliferation via interacting with NPM1 in esophageal squamous cell carcinoma

Wang, F.; Cheng, C.; Wang, X.; Chen, F.; Li, H.; Zhou, Y.; Wang, Y.; Hu, X.; Kong, P.; Zhang, L.; Cheng, X.; Cui, Y.

10.1101/2022.01.10.475754 — cancer biology — Posted on 2022-01-12

2616 MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas

Stopfer, L. E.; Rettko, N.; Leddy, O.; Mesfin, J. M.; Brown, E.; Winski, S.; Bryson, B. D.; Wells, J. A.; White, F.

10.1101/2022.01.10.475285 — cancer biology — Posted on 2022-01-12

2617 Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

Gerum, R. C.; Mirzahossein, E.; Eroles, M.; Elsterer, J.; Mainka, A.; Bauer, A.; Sonntag, S.; Winterl, A.; Bartl, J.; Fischer, L.; Abuhattum, S.; Goswami, R.; Girardo, S.; Guck, J.; Schruefer, S.; Stroehlein, N.; Nosratlo, M.; Herrmann, H.; Schultheis, D.; Rico, F.; Mueller, S.; Gekle, S.; Fabry, B.

10.1101/2022.01.11.475843 — biophysics — Posted on 2022-01-12

2618 Computational Prediction of Heteromeric Protein Complex Disassembly Order with Hybrid Monte Carlo/Molecular Dynamics Simulation

Kurisaki, I.; Tanaka, S.

10.1101/2022.01.12.476000 — biophysics — Posted on 2022-01-12

2619 Peak Space Motion Artifact Cancellation Applied to Textile Electrode Waist Electrocardiograms Recording During Outdoors Walking and Jogging

Hopenfeld, B. R.

10.1101/2022.01.07.475456 — bioengineering — Posted on 2022-01-12

2620 Limb, joint and pelvic kinematic control in the quail coping with step perturbations

Andrada, E.; Mothes, O.; Stark, H.; Tresch, M. C.; Denzler, J.; Fischer, M. S.; Blickhan, R.

10.1101/2022.01.11.475813 — animal behavior and cognition — Posted on 2022-01-12

2621 The heritability of BMI varies across the range of BMI: a heritability curve analysis in a twin cohort

Azzolini, F.; Berentsen, G.; Skaug, H.; Hjelmborg, J.; Kaprio, J.

10.1101/2022.01.06.475210 — genetics — Posted on 2022-01-12

2622 Automation of tree-ring detection and measurements using deep learning

Polacek, M.; Arizpe, A.; Hüther, P.; Weidlich, L.; Steindl, S.; Swarts, K.

10.1101/2022.01.10.475709 — ecology — Posted on 2022-01-12

2623 Heritable and climatic sources of variation in juvenile tree growth in an Austrian common garden experiment of Central European Norway spruce populations

Morales, L.; Swarts, K.

10.1101/2022.01.10.475611 — ecology — Posted on 2022-01-12

2624 SLC38A2 provides proline to fulfil unique synthetic demands arising during osteoblast differentiation and bone formation.

Shen, L.; Yu, Y.; Zhou, Y.; Pruett-Miller, S. M.; Zhang, G.-F.; Karner, C. M.

10.1101/2022.01.12.475981 — developmental biology — Posted on 2022-01-12

2625 Amniotic fluid stem cell extracellular vesicles promote fetal lung branching and cell differentiation in experimental congenital diaphragmatic hernia

Khalaj, K.; Figueira, R. L.; Antounians, L.; Gandhi, S.; Wales, M.; Montalva, L.; Biouss, G.; Zani, A.

10.1101/2022.01.10.475632 — developmental biology — Posted on 2022-01-12

2626 Novel modification of Luminex assay for characterization of extracellular vesicle populations in biofluids.

Volpert, O. V.; Gershun, E.; Elgart, K.; Kalia, V.; Wu, H.; Baccarelli, A. A.; Eren, E.; Kapogiannis, D.; Verma, A.; Levine, A.; Eitan, E.

10.1101/2022.01.12.475897 — cell biology — Posted on 2022-01-12

2627 Ionophore-stimulation promotes re-organization of the invasion machinery of Toxoplasma gondii

Segev-Zarko, L.-a.; Dahlberg, P. D.; Sun, S. Y.; Pelt, D. M.; Sethian, J. A.; Chiu, W.; Boothroyd, J. C.

10.1101/2022.01.12.476068 — cell biology — Posted on 2022-01-12

2628 Engineered cell differentiation and sexual reproduction in probiotic and mating yeasts

Jensen, E. D.; Deichmann, M.; Ma, X.; Vilandt, R. U.; Schiesaro, G.; Rojek, M. B.; Lengger, B.; Eliasson, L.; Vento, J. M.; Durmusoglu, D.; Hovmand, S. P.; Al'Abri, I.; Zhang, J.; Crook, N. C.; Jensen, M. K.

10.1101/2022.01.11.475777 — cell biology — Posted on 2022-01-12

2629 Vascular topology is acutely impacted by experimental febrile status epilepticus

Salehi, A.; Salari, S.; Daglian, J.; Chen, K.; Baram, T.; Obenaus, A.

10.1101/2022.01.10.475698 — neuroscience — Posted on 2022-01-12

2630 Spinal cord homeostatic plasticity gates mechanical allodynia in chronic pain

Cao, B.; Scherrer, G.; Chen, L.

10.1101/2022.01.10.475704 — neuroscience — Posted on 2022-01-12

2631 Signal denoising through topographic modularity of neural circuits

Zajzon, B.; Dahmen, D.; Morrison, A.; Duarte, R.

10.1101/2022.01.10.475681 — neuroscience — Posted on 2022-01-12

2632 Practical and Thermodynamic Constraints on Electromicrobially-Accelerated CO2 Mineralization

Marecos, S.; Brigham, R.; Dressel, A.; Gaul, L.; Li, L.; Satish, K.; Tjokorda, I.; Zheng, J.; Schmitz, A.; Barstow, B.

10.1101/2022.01.09.475503 — synthetic biology — Posted on 2022-01-12

2633 Augmentation of extracellular ATP synergizes with chemotherapy in triple negative breast cancer

Manouchehri, J. M.; Datta, J.; Willingham, N.; Wesolowski, R.; Stover, D. A.; Ganju, R. K.; Carson, W.; Ramaswamy, B.; Cherian, M. A.

10.1101/2022.01.11.475873 — cancer biology — Posted on 2022-01-12

2634 cpSRP43 is both highly flexible and stable: Structural insights using a combined experimental and computational approach

Benton, M.; Furr, M.; Govind Kumar, V.; Gao, F.; Heyes, C. D.; Suresh Kumar, T. K.; Moradi, M.

10.1101/2022.01.11.475959 — biophysics — Posted on 2022-01-12

2635 Human endothelial cells display a rapid and fluid flow dependent tensional stress increase in response to tumor necrosis factor-α

Brandt, M.; Gerke, V.; Betz, T.

10.1101/2022.01.12.476017 — biophysics — Posted on 2022-01-12

2636 Strand-switching mechanism of Pif1 helicase induced by its collision with a G-quadruplex embedded in dsDNA

Valle-Orero, J.; Rieu, M.; Tran, P. L. T.; Joubert, A.; Allemand, J.-F.; Croquette, V.; Boule, J.-B.

10.1101/2022.01.11.475363 — biophysics — Posted on 2022-01-12

2637 Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins

Zeng, X.; Ruff, K. M.; Pappu, R. V.

10.1101/2022.01.11.475920 — biophysics — Posted on 2022-01-12

2638 How many bits of information can be transferred between residues in a protein and how fast?

Hacisuleyman, A.; Erman, B.

10.1101/2022.01.10.475716 — biophysics — Posted on 2022-01-12

2639 Structural basis of ion - substrate coupling in the Na+-dependent dicarboxylate transporter VcINDY

Sauer, D.; Marden, J. J.; Sudar, J. C.; Song, J.; Mulligan, C.; Wang, D.-N.

10.1101/2022.01.11.475879 — biophysics — Posted on 2022-01-12

2640 Developmental origins of cell heterogeneity in the human lung

Sountoulidis, A.; Marco Salas, S.; Braun, E.; Avenel, C.; Bergenstrahle, J.; Vicari, M.; Czarnewski Barenco, P. V.; Theelke, J.; Liontos, A.; Abalo, X.; Andrusivova, Z.; Asp, M.; Li, X.; Hu, L.; Sariyar, S.; Martinez Casals, A.; Ayoglu, B.; Firsova, A. B.; Michaelsson, J.; Lundberg, E.; Wählby, C.; Sundström, E.; Linnarsson, S.; Lundeberg, J.; Nilsson, M.; Samakovlis, C.

10.1101/2022.01.11.475631 — developmental biology — Posted on 2022-01-12

2641 Ontogenetic Color Switching in Lizards as a by-Product of Guanine Cell Development

Zhang, G.; Yallapragada, V. J.; Shemesh, M.; Wagner, A.; Upcher, A.; Pinkas, I.; McClelland, H. L. O.; Hawlena, D.; Palmer, B. A.

10.1101/2022.01.12.475993 — developmental biology — Posted on 2022-01-12

2642 Differential Requirement of DICER1 Activity during Development of Mitral and Tricuspid Valves

Yan, S.; Peng, Y.; Lu, J.; Shakil, S.; Shi, Y.; Crossman, D. K.; Johnson, W. H.; Liu, S.; Lincoln, J.; Wang, Q.; Jiao, K.

10.1101/2022.01.10.475694 — developmental biology — Posted on 2022-01-12

2643 Microscopic and ultramicroscopic anatomical characteristics of root nodules in Podocarpus macrophyllus during development

Zhu, L.; Chen, H.; Zhao, L.; Jiang, W.

10.1101/2022.01.11.475828 — developmental biology — Posted on 2022-01-12

2644 A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration

Jia, Y.

10.1101/2022.01.11.475943 — cell biology — Posted on 2022-01-12

2645 Pericentrin is a Kinesin-1 Activator that Drives Centriole Motility

Hannaford, M. R.; Liu, R.; Billington, N.; Swider, Z. T.; Galletta, B. J.; Fagerstrom, C. J.; Combs, C.; Sellers, J. R.; Rusan, N. M.

10.1101/2022.01.12.476023 — cell biology — Posted on 2022-01-12

2646 Functional interplay between arginyl-tRNA synthetases and arginyltransferase

Avcilar-Kucukgoze, I.; Kashina, A.

10.1101/2022.01.11.475907 — cell biology — Posted on 2022-01-12

2647 Canonical Wnt Signaling Induces Focal Adhesion and Integrin Beta-1 Endocytosis

Tejeda-Munoz, N.; Morselli, M.; Moriyama, Y.; Sheladiya, P.; Pellegrini, M.; De Robertis, E.

10.1101/2022.01.11.475934 — cell biology — Posted on 2022-01-12

2648 Transgenerational transcriptional heterogeneity from cytoplasmic chromatin

Papathanasiou, S.; Mynhier, N. A.; Liu, S.; Jacob, E.; Stokasimov, E.; van Steensel, B.; Zhang, C.-Z.; Pellman, D.

10.1101/2022.01.12.475869 — cell biology — Posted on 2022-01-12

2649 Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging

Liu, L.; Buckley, M. T.; Reyes, J. M.; Kim, S.; Tian, L.; Wang, T.; Lieu, A.; Mao, M.; Mateo-Rodriguez, C.; Ishak, H.; Jeong, M.; Wu, J. C.; Goodell, M. A.; Brunet, A.; Rando, T. A.

10.1101/2022.01.12.475145 — cell biology — Posted on 2022-01-12

2650 UV-C light completely blocks highly contagious Delta SARS-CoV-2 aerosol transmission in hamsters

Fischer, R.; Port, J. R.; Holbrook, M.; Yinda, K. C.; Creusen, M.; ter Stege, J.; de Samber, M.; Munster, V.

10.1101/2022.01.10.475722 — microbiology — Posted on 2022-01-12

2651 Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery

Chen, S. T.; Park, M. D.; Del Valle, D. M.; Buckup, M.; Tabachnikova, A.; Simons, N. W.; Mouskas, K.; Lee, B.; Geanon, D.; D'Souza, D.; Dawson, T.; Marvin, R.; Nie, K.; Thompson, R.; Zhao, Z.; LeBerichel, J.; Chang, C.; Jamal, H.; Chaddha, U.; Mathews, K.; Acquah, S.; Brown, S.-A.; Reiss, M.; Harkin, T.; Feldmann, M.; Powell, C. A.; Hook, J.; Kim-Schulze, S.; Rahman, A. H.; Brown, B.; The COVID-19 Biobank Team, ; Beckmann, N. D.; Gnjatic, S.; Kenigsberg, E.; Charney, A.; Merad, M.

10.1101/2022.01.11.475918 — immunology — Posted on 2022-01-12

2652 Investigation of the Effects of N-Linked Glycans on the Stability of the Spike Protein in SARS-CoV-2 by Molecular Dynamics Simulations

Tekin, E. D.

10.1101/2022.01.07.475397 — biophysics — Posted on 2022-01-12

2653 GenomeBits insight into omicron and delta variants of coronavirus pathogen

Canessa, E.; Tenze, L.

10.1101/2022.01.11.475877 — bioinformatics — Posted on 2022-01-12

2654 A novel structure-based approach for identification of vertebrate susceptibility to SARS-CoV-2: implications for future surveillance programmes

Kaushik, R.; Kumar, N.; Zhang, K. Y. J.; Srivastava, P.; Bhatia, S.; Malik, Y. S.

10.1101/2022.01.10.475752 — bioinformatics — Posted on 2022-01-12

2655 Head Removal Enhances Planarian Electrotaxis

Sabry, Z.; Wang, R.; Jahromi, A.; Rabeler, C.; Kristan, W. B.; Collins, E.-M.

10.1101/2022.01.10.475627 — animal behavior and cognition — Posted on 2022-01-12

2656 Abscisic Acid Increases Hydrogen Peroxide in Multiple Subcellular Compartments to Drive Stomatal Closure

Postliglione, A. E.; Muday, G. K.

10.1101/2022.01.11.475946 — plant biology — Posted on 2022-01-12

2657 Innovative multidimensional models in a high-throughput-format for different cell types of endocrine origin

Bornstein, S. R.; Shapiro, I.; Malyukov, M.; Züllig, R.; Luca, E.; Gelfgat, E.; Beuschlein, F.; Nölting, S.; Berruti, A.; Sigala, S.; Peitzsch, M.; Steenblock, C.; Ludwig, B.; Kugelmeier, P.; Hantel, C.

10.1101/2022.01.10.475686 — cancer biology — Posted on 2022-01-12

2658 Differential sensory and immune gene evolution in sea turtles with contrasting demographic and life histories

10.1101/2022.01.10.475373 — genomics — Posted on 2022-01-12

2659 Escherichia coli YigI is a conserved γ-proteobacterial acyl-CoA thioesterase permitting metabolism of unusual fatty acid substrates

Schmidt, M.; Proctor, T.; Diao, R.; Freddolino, P. L.

10.1101/2022.01.10.475765 — microbiology — Posted on 2022-01-12

2660 Insights into the structure and function of the human organic anion transporter 1 in lipid bilayer membranes

Janaszkiewicz, A.; Toth, A.; Faucher, Q.; Martin, M.; Chantemargue, B.; Barin-Le Guellec, C.; Marquet, P.; Di Meo, F.

10.1101/2022.01.10.475390 — pharmacology and toxicology — Posted on 2022-01-12

2661 A UHM - ULM interface contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

Galardi, J.; Bela, V. N.; Jeffery, N.; He, X.; Glasser, E.; Loerch, S.; Jenkins, J. L.; Pulvino, M. J.; Boutz, P. L.; Kielkopf, C. L.

10.1101/2022.01.09.475535 — biochemistry — Posted on 2022-01-12

2662 Evidence for quinol oxidase activity of ImoA, a novel NapC/NirT family protein from the neutrophilic Fe(II) oxidizing bacterium Sideroxydans lithotrophicus ES-1

Jain, A.; Coelho, A.; Madjarov, J.; Todorovic, S.; Louro, R. O.; Gralnick, J. A.; Paquete, C. M.

10.1101/2022.01.10.475773 — biochemistry — Posted on 2022-01-12

2663 Performance evaluation of three DNA sample tracking tools in a whole exome sequencing workflow

Wils, G.; Helmoortel, C.; Volders, P.-J.; Vereecke, I.; Milazzo, M. A.; Vandesompele, J.; Coppieters, F.; De Leeneer, K.; Lefever, S.

10.1101/2022.01.11.475818 — genomics — Posted on 2022-01-12

2664 An analysis of LysM domain function in LytE when fulfilling the D,L-endopeptidase requirement for viability in Bacillus subtilis

Uelze, L.

10.1101/2022.01.12.475998 — genomics — Posted on 2022-01-12

2665 Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain

Buckley, M. T.; Sun, E.; George, B. M.; Liu, L.; Schaum, N.; Xu, L.; Reyes, J. M.; Goodell, M. A.; Weissman, I. L.; Wyss-Coray, T.; Rando, T. A.; Brunet, A.

10.1101/2022.01.10.475747 — genomics — Posted on 2022-01-12

2666 The draft genome sequence of Japanese rhinoceros beetle Trypoxylus dichotomus

Morita, S.; Shibata, T. F.; Nishiyama, T.; Kobayashi, Y.; Yamaguchi, K.; Toga, K.; Ohde, T.; Gotoh, H.; Kojima, T.; Weber, J.; Salvemini, M.; Bino, T.; Mase, M.; Nakata, M.; Mori, T.; Mori, S.; Cornette, R.; Sakura, K.; Lavine, L. C.; Emlen, D. J.; Niimi, T.; Shigenobu, S.

10.1101/2022.01.10.475740 — genomics — Posted on 2022-01-12

2667 High content Image Analysis to study phenotypic heterogeneity in endothelial cell monolayers

Chesnais, F. L.; Hue, J.; Roy, E.; Branco, M.; Stokes, R.; Pellon, A.; Le Caillec, J.; Elbahtety, E.; Battilocchi, M.; Danovi, D.; Veschini, L.

10.1101/2020.11.17.362277 — cell biology — Posted on 2022-01-12

2668 SARS-CoV-2 Point Mutation and Deletion Spectra, and Their Association with Different Disease Outcome

Martinez-Gonzalez, B.; Soria, M. E.; Vazquez-Sirvent, L.; Ferrer-Orta, C.; Lobo-Vega, R.; Minguez, P.; De la Fuente, L.; Llorens, C.; Soriano, B.; Ramos-Ruiz, R.; Corton, M.; Lopez-Rodriguez, R.; Garcia-Crespo, C.; Gallego, I.; de Avila, A. I.; Gomez, J.; Enjuanes, L.; Salar-Vidal, L.; Esteban, J.; Fernandez Roblas, R.; Gadea Girones, I.; Ayuso, C.; Ruiz-Hornillos, J.; Verdaguer, N.; Domingo, E.; Perales, C.

10.1101/2022.01.10.475768 — microbiology — Posted on 2022-01-12

2669 Low and high frequency intracranial neural signals match in the human associative cortex

Jacques, C.; Jonas, J.; Colnat-Coulbois, S.; Maillard, L.; Rossion, B.

10.1101/2022.01.09.475577 — neuroscience — Posted on 2022-01-12

2670 Circadian and diel regulation of photosynthesis in the bryophyte Marchantia polymorpha

Cuitun-Coronado, D.; Rees, H.; Hall, A.; de Barros Dantas, L. L.; Dodd, A. N.

10.1101/2022.01.11.475783 — plant biology — Posted on 2022-01-12

2671 Cell surface receptor kinase FERONIA linked to nutrient sensor TORC1 signaling controls root hair growth at low temperature in Arabidopsis thaliana

Pacheco, J. M.; Song, L.; Gabarain, V. B.; Peralta, J. M.; Lehuede, T. U.; Ibeas, M. A.; Zhu, S.; Shen, Y.; Yu, F.; Estevez, J. M.

10.1101/2022.01.10.475584 — plant biology — Posted on 2022-01-12

2672 Processing body dynamics drive non-genetic MEK inhibitors tolerance by fine-tuning KRAS and NRAS translation

Vidal-Cruchez, O.; Nicolini, V. J.; Rete, T.; Rezzonico, R.; Lacoux, C.; Fassy, J.; Jacquet, K.; Domdom, M. A.; Ventujol, C.; Juhel, T.; Romeo, B.; Roux, J.; Hubstenberger, A.; Mari, B.; Mograbi, B.; Hofman, P.; Brest, P.

10.1101/2021.12.06.471470 — cancer biology — Posted on 2022-01-12

2673 Lipid nanoparticles delivering constitutively active STING mRNA as a novel anti-cancer therapeutic approach

Liu, W.; Alameh, M.-G.; Yang, J. F.; Xu, J. R.; Lin, P. J.; Tam, Y. K.; Weissman, D.; You, J.

10.1101/2022.01.08.475499 — bioengineering — Posted on 2022-01-12

2674 HDX-MS performed on BtuB in E. coli outer membranes delineates the luminal domain's allostery and unfolding upon B12 and TonB binding

Zmyslowski, A. M.; Baxa, M. C.; Gagnon, I. A.; Sosnick, T. R.

10.1101/2022.01.07.475440 — biochemistry — Posted on 2022-01-12

2675 Intellectual disability-associated disruption of O-GlcNAcylation impairs neuronal development and cognitive function in Drosophila

Fenckova, M.; Muha, V.; Mariyappa, D.; Catinozzi, M.; Czajewski, I.; Blok, L. E. R.; Ferenbach, A. T.; Storkebaum, E.; Schenck, A.; van Aalten, D. M. F.

10.1101/2022.01.10.475726 — genetics — Posted on 2022-01-12

2676 AF-vapeR: A multivariate genome scan for detecting parallel evolution using allele frequency change vectors

Whiting, J. R.; Paris, J. R.; van der Zee, M.; Fraser, B. A.

10.1101/2021.09.17.460770 — evolutionary biology — Posted on 2022-01-12

2677 Cell Rearrangement Generates Pattern Emergence as a Function of Temporal Morphogen Exposure.

Fulton, T.; Spiess, K.; Thomson, L.; Wang, Y.; Clark, B.; Hwang, S.; Paige, B.; Verd, B.; Steventon, B.

10.1101/2021.02.05.429898 — developmental biology — Posted on 2022-01-12

2678 Differential metabolism of arsenicals regulates Fps1-mediated arsenite transport

Lee, J.; Levin, D. E.

10.1101/2021.10.12.464049 — molecular biology — Posted on 2022-01-12

2679 The bacterial hitchhiker's guide to COI: Universal primer-based COI capture probes fail to exclude bacterial DNA, but 16S capture leaves metazoa behind

Hintikka, S.; Carlsson, J. E. L.; Carlsson, J.

10.1101/2021.11.28.470224 — molecular biology — Posted on 2022-01-12

2680 Perturbation of alphavirus and flavivirus infectivity by components of the bacterial cell wall

Langendries, L.; Jacobs, S.; Abdelnabi, R.; Verwimp, S.; Kaptein, S.; Baatsen, P.; Van Mellaert, L.; Delang, L.

10.1101/2021.05.07.443110 — microbiology — Posted on 2022-01-12

2681 Microbiomes in drinking water treatment and distribution: a critical review and meta-analysis from source to tap

Thom, C.; Smith, C. J.; Moore, G.; Weir, P.; Ijaz, U. Z.

10.1101/2021.08.30.457654 — microbiology — Posted on 2022-01-12

2682 Dendritic integration of sensory and reward information facilitates learning

Schoenfeld, G.; Kollmorgen, S.; Lewis, C. M.; Bethge, P.; Reuss, A. M.; Aguzzi, A.; Mante, V.; Helmchen, F.

10.1101/2021.12.28.474360 — neuroscience — Posted on 2022-01-12

2683 Enhancement of central norepinephrinergic neurotransmission contributes to inhibition of seizure-induced respiratory arrest by targeting the beta-1 adrenergic receptor (β1-AR) locating in the cardiomyocytes in the DBA/1 mouse SUDEP model

Lian, X.; Yu, Q.; Ma, H.; Gu, L.; Xu, Q.; Zhang, H.

10.1101/2022.01.10.475630 — neuroscience — Posted on 2022-01-12

2684 A Proposal for Finite But Unbounded Human Lifetimes

Huang, F.; Maller, R.; Milholland, B.; Ning, X.

10.1101/2022.01.07.474862 — systems biology — Posted on 2022-01-12

2685 Lipid-mediated Association of the Slg1 Transmembrane Domains in Yeast Plasma Membranes

Alavizargar, A.; Elting, A.; Wedlich Soeldner, R.; Heuer, A.

10.1101/2021.06.29.450341 — biophysics — Posted on 2022-01-12

2686 AI for predicting chemical-effect associations at the universe level - deepFPlearn

Schor, J.; Scheibe, P.; Berndt, M.; Busch, W.; Lai, C.; Hackermüller, J.

10.1101/2021.06.24.449697 — bioinformatics — Posted on 2022-01-12

2687 Machine learning models based on molecular descriptors to predict human and environmental toxicological factors in continental freshwater

Servien, R.; Latrille, E.; Patureau, D.; Helias, A.

10.1101/2021.07.20.453034 — biochemistry — Posted on 2022-01-12

2688 Rotavirus RNA chaperone mediates global transcriptome-wide increase in RNA backbone flexibility

Coria, A.; Wienecke, A.; Borodavka, A.; Laederach, A.

10.1101/2022.01.04.474988 — biochemistry — Posted on 2022-01-12

2689 'rbioacc': an R-package to analyse toxicokinetic data

Ratier, A.; Baudrot, V.; Kaag, M.; Siberchicot, A.; Lopes, C.; CHARLES, S.

10.1101/2021.09.08.459421 — ecology — Posted on 2022-01-12

2690 Design Maps of TRPM8 as a Thermometer for Cold Detection

Wang, G.

10.1101/2022.01.02.474742 — biophysics — Posted on 2022-01-12

2691 Dendritic branch structure compartmentalizes voltage-dependent calcium influx in cortical layer 2/3 pyramidal cells

Landau, A. T.; Park, P.; Wong-Campos, D.; He, T.; Cohen, A. E.; Sabatini, B.

10.1101/2022.01.11.475883 — neuroscience — Posted on 2022-01-12

2692 A thalamo-preoptic pathway promoting social touch

Keller, D.; Lang, T.; Cservenak, M.; Puska, G.; Barna, J.; Csillag, V.; Farkas, I.; Zelena, D.; Fanni, D.; Barteczko, L.; B. Usdin, T.; Palkovits, M.; T. Hasan, M.; Grinevich, V.; Dobolyi, A.

10.1101/2022.01.11.475648 — neuroscience — Posted on 2022-01-12

2693 Multidimensional cerebellar computations for flexible kinematic control of movements

Markanday, A.; Hong, S.; Inoue, J.; De Schutter, E.; Thier, P.

10.1101/2022.01.11.475785 — neuroscience — Posted on 2022-01-12

2694 Responses to song playback differ in sleeping versus anesthetized songbirds

Bottjer, S. W.; Le Moing, C. L.; Li, E. J.; Yuan, R. C.

10.1101/2022.01.11.475714 — neuroscience — Posted on 2022-01-12

2695 Precise DNA Cloning via PAMless CRISPR-SpRYgests

Christie, K. A.; Guo, J. A.; Silverstein, R. A.; Doll, R. M.; Mabuchi, M.; Stutzman, H. E.; Ma, L.; Robb, G. B.; Kleinstiver, B. P.

10.1101/2022.01.11.474553 — biochemistry — Posted on 2022-01-12

2696 Effects of larval diet on the life-history traits and phenotypic expression of pyrethroid resistance in the major malaria vector Anopheles gambiae s.s.

Sovegnon, P. M.; Fanou, M. J.; Akoton, R.; Djihinto, O. Y.; Lagnika, H. O.; Agonhossou, R.; Djogbenou, L.

10.1101/2022.01.11.475801 — zoology — Posted on 2022-01-11

2697 Phase tracking algorithms detect both real and imaginary components of outer hair cell nonlinear membrane capacitance that exhibits dielectric loss.

Santos-Sacchi, J.

10.1101/2022.01.01.474702 — biophysics — Posted on 2022-01-11

2698 Parasitized or non-parasitized, why? A study of factors influencing tick burden in roe deer neonates.

Bariod, L.; Saïd, S.; Calenge, C.; Badeau, V.; Chabot, S.; Bourgoin, G.

10.1101/2022.01.11.475805 — ecology — Posted on 2022-01-11

2699 OverFlap PCR - a reliable approach for generation of plasmid DNA libraries containing random sequences without template bias.

Linars, A.; Silamikelis, I.; Gudra, D.; Roga, A.; Fridmanis, D.

10.1101/2022.01.11.475799 — molecular biology — Posted on 2022-01-11

2700 The Antimicrobial Activity of Pechuel-Loeschea leubnitziae Leaf Extract and its Effect on The Expression Level of Methicillin Resistant Staphylococcus Aureus and Candida albicans Virulence-Associated Genes

Muhongo, M. N.; Kangogo, M.; Bii, C.

10.1101/2022.01.11.475881 — molecular biology — Posted on 2022-01-11

2701 Identification of Salivary Gland Escape Barriers to Western Equine Encephalitis Virus in the Natural Vector, Culex tarsalis

Stauft, C. B.; Phillips, A. T.; Wang, T. T.; Olson, K.

10.1101/2022.01.11.475797 — microbiology — Posted on 2022-01-11

2702 State-dependent representation of mixtures by the olfactory bulb

Adefuin, A. M.; Lindeman, S.; Reinert, J. K.; Fukunaga, I.

10.1101/2021.09.23.461425 — neuroscience — Posted on 2022-01-11

2703 Electrical impulse characterization along actin filaments in pathological conditions

Hunley, C.; Mohsin, M.; Marucho, M.

10.1101/2021.09.03.458927 — neuroscience — Posted on 2022-01-11

2704 Neural Regression, Representational Similarity, Model Zoology & Neural Taskonomy at Scale in Rodent Visual Cortex

Conwell, C.; Mayo, D.; Katz, B.; Buice, M. A.; Alvarez, G. A.; Barbu, A.

10.1101/2021.06.18.448431 — neuroscience — Posted on 2022-01-11

2705 Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors

Wenker, S. D.; Gradaschi, V.; Ferrari, C.; Farias, M. I.; Garcia, C.; Beauquis, J.; Zeng, X.; Pitossi, F. J.

10.1101/2022.01.11.475933 — neuroscience — Posted on 2022-01-11

2706 Forward masking in a bottlenose dolphin Tursiops truncatus : Dependence on azimuthal positions of the masker and test sources

Popov, V.; Nechaev, D.; Supin, A. Y.; Sysueva, E.

10.1101/2022.01.11.475800 — physiology — Posted on 2022-01-11

2707 Evaluation of the anti-tumor activities of Sulfonylurea Derivatives

Zhou, S.; Lu, S.; Guo, C.; Wu, L.; Zheng, Z.; Hua, X.; Wei, W.; Zhang, W.; Zhou, S.; Li, R.

10.1101/2022.01.11.475798 — biochemistry — Posted on 2022-01-11

2708 Phylogenetic and protein prediction analysis reveals the taxonomically diverse distribution of virulence factors in the Bacillus cereus group

Zhang, M.; Liu, J.; Yin, Z.; Zhang, L.

10.1101/2022.01.11.475806 — evolutionary biology — Posted on 2022-01-11

2709 Consumer-driven nutrient recycling of freshwater decapods: linking ecological theories and application in integrated multi-trophic aquaculture

Musin, G.; Torres, M. V.; Carvalho, D. d. A.

10.1101/2022.01.11.475807 — ecology — Posted on 2022-01-11

2710 Filamentous Bacteriophage Delay Healing of Pseudomonas-Infected Wounds

Bach, M. S.; de Vries, C. R.; Khosravi, A.; Sweere, J. M.; Popescu, M.; Hargil, A.; Van Belleghem, J. D.; Kaber, G.; Chen, Q.; Burgener, E. B.; Liu, D.; Tran, Q.-L.; Dharmaraj, T.; Birukova, M.; Sunkari, V.; Balaji, S.; Ghosh, N.; Mathew-Steiner, S. S.; Keswani, S.; Banaei, N.; Nedelec, L.; Sen, C. K.; Chandra, V.; Secor, P. R.; Suh, G. A.; Bollyky, P. L.

10.1101/2020.03.10.985663 — microbiology — Posted on 2022-01-11

2711 Caveolae respond to acute oxidative stress through membrane lipid peroxidation, cytosolic release of CAVIN1, and downstream regulation of NRF2

Wu, Y.; Lim, Y.-W.; Stroud, D. A.; Martel, N.; Hall, T. E.; Lo, H.; Ferguson, C.; Ryan, M. T.; McMahon, K.-A.; Parton, R. G.

10.1101/2021.06.09.447684 — cell biology — Posted on 2022-01-11

2712 A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

10.1101/2021.11.29.470356 — immunology — Posted on 2022-01-11

2713 Latent functional connectivity underlying multiple brain states

McCormick, E. M.; Arnemann, K. L.; Ito, T.; Hanson, S. J.; Cole, M. W.

10.1101/2021.04.05.438534 — neuroscience — Posted on 2022-01-11

2714 Towards routine employment of computational tools for antimicrobial resistance determination via high-throughput sequencing

Marini, S.; Mora, R.; Boucher, C.; Noyes, N.; Prosperi, M.

10.1101/2021.11.03.467126 — genomics — Posted on 2022-01-11

2715 Weakly deleterious natural genetic variation greatly amplifies probability of resistance in multiplexed gene drive systems

Khatri, B. S.; Burt, A.

10.1101/2021.12.23.473701 — evolutionary biology — Posted on 2022-01-11

2716 Drift as a driver of language change: An artificial language experiment

Ventura, R.; Plotkin, J. B.; Roberts, G.

10.1101/2021.03.26.437270 — evolutionary biology — Posted on 2022-01-11

2717 Sensitization of Chrysosplenetin against Artemisinin Resistant Plasmodium berghei K173 via Blocking Host ABC Transporters Potentially Mediated by NF-κBB p52 or PXR/CAR Signaling Pathway

Chen, J.; Zhao, X.; Ni, S.; Zhang, Y.; Wu, X.; Yao, Y.

10.1101/2022.01.10.475770 — molecular biology — Posted on 2022-01-11

2718 Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs

Obr, M.; Hagen, W. J.; Dick, R. A.; Yu, L.; Kotecha, A.; Schur, F. K.

10.1101/2022.01.10.475481 — molecular biology — Posted on 2022-01-11

2719 Meiotic pairing and double strand break formation along the heteromorphic threespine stickleback sex chromosomes

Nath, S.; Welch, L. A.; Flanagan, M. K.; White, M. A.

10.1101/2022.01.11.475862 — molecular biology — Posted on 2022-01-11

2720 A honey bee symbiont buffers larvae against nutritional stress through lysine supplementation

Parish, A. J.; Rice, D. W.; Tanquary, V. M.; Tennessen, J. M.; Newton, I. L.

10.1101/2022.01.11.475899 — microbiology — Posted on 2022-01-11

2721 Survival and Transcriptomic Response of Clinically relevant pathogens on Surfaces in Relation to Probiotic and Traditional Cleaning Strategies

Hu, J.; Shuai, W.; Sumner, J. T.; Moghadam, A. A.; Hartmann, E. M.

10.1101/2022.01.11.475867 — microbiology — Posted on 2022-01-11

2722 In situ structure and priming mechanism of the rhoptry secretion system in Plasmodium revealed by cryo-electron tomography

Martinez, M.; Chen, W. D.; Cova, M.; Molnar, P. A.; Mageswaran, S. K.; Guerin, A.; John, A. R. O.; Lebrun, M.; Chang, Y.-W.

10.1101/2022.01.11.475861 — microbiology — Posted on 2022-01-11

2723 Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Hansen, J. Y.; Shafiei, G.; Markello, R. D.; Smart, K.; Cox, S. M.; Norgaard, M.; Beliveau, V.; Wu, Y.; Gallezot, J.-D.; Aumont, E.; Servaes, S.; Scala, S. G.; Dubois, J. M.; Wainstein, G.; Bezgin, G.; Funck, T.; Schmitz, T. W.; Spreng, R. N.; Galovic, M.; Koepp, M. J.; Duncan, J. S.; Coles, J. P.; Fryer, T. D.; Aigbirhio, F. I.; McGinnity, C. J.; Hammers, A.; Soucy, J.-P.; Baillet, S.; Guimond, S.; Hietala, J.; Bedard, M.-A.; Leyton, M.; Kobayashi, E.; Rosa-Neto, P.; Ganz, M.; Knudsen, G. M.; Palomero-Gallagher, N.; Shine, J.; Carson, R. E.; Tuominen, L.; Dagher, A.; Misic, B.

10.1101/2021.10.28.466336 — neuroscience — Posted on 2022-01-11

2724 Behavioral distractibility in preschoolers from different socio-economic backgrounds

Hoyer, R. S.; Pakulak, E.; Bidet-Caulet, A.; Karns, C. M.

10.1101/2021.04.06.438161 — neuroscience — Posted on 2022-01-11

2725 A flux-based machine learning model to simulate the impact of pathogen metabolic heterogeneity on drug interactions

Chung, C. H.; Chandrasekaran, S.

10.1101/2021.08.03.454957 — systems biology — Posted on 2022-01-11

2726 Highly efficient multiplex genome editing in dicot plants using improved CRISPR/Cas systems

Li, B.; Shang, Y.; Wang, L.; Lv, J.; Wang, F.; Chao, J.; Mao, J.; Ding, A.; Wu, X.; Cui, M.; Sun, Y.; Dai, C.

10.1101/2022.01.10.475635 — plant biology — Posted on 2022-01-11

2727 Bioinformatics Analysis of the Potentially Functional circRNA-miRNA-mRNA Network in Breast Cancer

Erdogan, C.; Suer, I.; Kaya, M.; Kurt, Z.; Ozturk, S.; Aydin, N.

10.1101/2022.01.10.475557 — bioinformatics — Posted on 2022-01-11

2728 Complete pan-plastome sequences enable high resolution phylogenetic classification of sugar beet and closely related crop wild relatives

Sielemann, K.; Pucker, B.; Schmidt, N.; Viehoever, P.; Weisshaar, B.; Heitkam, T.; Holtgraewe, D.

10.1101/2021.10.08.463637 — genomics — Posted on 2022-01-11

2729 Comparative reconstruction of the predatory feeding structures of the polyphenic nematode Pristionchus pacificus

Harry, C. J.; Messar, S. M.; Ragsdale, E. J.

10.1101/2021.10.15.464383 — evolutionary biology — Posted on 2022-01-11

2730 Machine learning for exploring microbial inter-kingdom associations in Cystic Fibrosis and Bronchiectasis

Cuthbertson, L.; Ish-horowicz, J.; Felton, I.; James, P.; Turek, E.; Cox, M. J.; Loebinger, M. R.; Simmonds, N. J.; Filippi, S. L.; Moffatt, M. F.; Cookson, W. O.

10.1101/2022.01.11.475678 — molecular biology — Posted on 2022-01-11

2731 Genomic occupancy of the bromodomain protein Bdf3 is dynamic during differentiation of African trypanosomes from bloodstream to procyclic forms

Ashby, E.; Paddock, L.; Betts, H. L.; Miller, G.; Porter, A.; Rollosson, L. M.; Saada, C.; Tang, E.; Wade, S. J.; Hardin, J.; Schulz, D.

10.1101/2022.01.11.475927 — molecular biology — Posted on 2022-01-11

2732 Single-molecule mapping of replisome progression

Claussin, C.; Vazquez, J.; Whitehouse, I.

10.1101/2022.01.10.475700 — molecular biology — Posted on 2022-01-11

2733 Quantitative Isothermal Amplification on Paper Membranes using Amplification Nucleation Site Analysis

Sullivan, B. P.; Chou, Y.-S.; Bender, A. T.; Martin, C. D.; Kaputa, Z. G.; March, H.; Song, M.; Posner, J. D.

10.1101/2022.01.11.475898 — molecular biology — Posted on 2022-01-11

2734 Structural insights as to how iron-loaded siderophores are imported into Mycobacterium tuberculosis by IrtAB

Zhang, B.; Rao, Z.; Yang, H.; Sun, S.; Gao, Y.; Yang, X.; Yang, X.; Hu, T.; Liang, J.; Xiong, Z.; Ren, P.; Bai, F.; Guddat, L. W.

10.1101/2022.01.11.475891 — molecular biology — Posted on 2022-01-11

2735 Oleic acid-related anti-inflammatory effects in force-stressed PdL fibroblasts are mediated by H3 lysine acetylation associated with altered IL10 expression

Schuldt, L.; von Brandenstein, K.; Jacobs, C.; Symmank, J.

10.1101/2022.01.11.475909 — molecular biology — Posted on 2022-01-11

2736 The phylogenomic landscape of the genus Serratia

Williams, D. J.; Grimont, P. A.; Cazares, A.; Grimont, F.; Ageron, E.; Pettigrew, K. A.; Cazares, D.; Njamkepo, E.; Weill, F.-X.; Heinz, E.; Holden, M. T.; Thomson, N.; Coulthurst, S. J.

10.1101/2022.01.11.475790 — microbiology — Posted on 2022-01-11

2737 Paradigm shift in eukaryotic biocrystallization

Pilatova, J.; Panek, T.; Obornik, M.; Cepicka, I.; Mojzes, P.

10.1101/2022.01.11.475817 — microbiology — Posted on 2022-01-11

2738 An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37

Kolesinski, P.; Wang, K.-C.; Hirose, Y.; Nizet, V.; Ghosh, P.

10.1101/2022.01.11.475926 — microbiology — Posted on 2022-01-11

2739 Heterocomplexes between the Atypical Chemokine MIF and the CXC-Motif Chemokine CXCL4L1 Regulate Inflammation and Thrombus Formation

Brandhofer, M.; Hoffmann, A.; Blanchet, X.; Siminkovitch, E.; Rohlfing, A.-K.; El Bounkari, O.; Nestele, J. A.; Bild, A.; Kontos, C.; Hille, K.; Rohde, V.; Froehlich, A.; Golemi, J.; Goekce, O.; Scheiermann, P.; Tsilimparis, N.; Kempf, W. E.; Maegdefessel, L.; Megens, R. T. A.; Ippel, H.; Koenen, R. R.; Mayo, K.; Gawaz, M.; Kapurniotu, A.; Weber, C.; von Hundelshausen, P.; Bernhagen, J.

10.1101/2021.11.26.470090 — immunology — Posted on 2022-01-11

2740 Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection

Fourati, S.; Jimenez-Morales, D.; Hultquist, J. F.; Chang, M. W.; Benner, C.; Krogan, N. J.; Pache, L.; Chanda, S.; Sekaly, R.-P.; Garcia-Sastre, A.; Uccellini, M. B.

10.1101/2022.01.10.475751 — immunology — Posted on 2022-01-11

2741 Glutamine is required for M1-like polarization in response to Mycobacterium tuberculosis infection

Shi, L.; Jiang, Q.; Qiu, Y.; Kurland, I. J.; Drlica, K.; Subbian, S.; Tyagi, S.

10.1101/2022.01.11.475775 — immunology — Posted on 2022-01-11

2742 SARS-CoV-2 triggers complement activation through interactions with heparan sulfate

Lo, M. W.; Amarilla, A. A.; Lee, J. D.; Albornoz, E. A.; Modhiran, N.; Clark, R. J.; Ferro, V.; Chhabra, M.; Khromykh, A. A.; Watterson, D.; Woodruff, T. M.

10.1101/2022.01.11.475820 — immunology — Posted on 2022-01-11

2743 Altered retinal structure and function in Spinocerebellar ataxia type 3

Toulis, V.; Casaroli-Marano, R.; Camos-Carreras, A.; Figueras-Roca, M.; Sanchez-Dalmau, B.; Munoz, E.; Ashraf, N. S.; Ferreira, A. F.; Khan, N.; MARFANY, G.; Costa, M. d. C.

10.1101/2022.01.10.475670 — neuroscience — Posted on 2022-01-11

2744 Efficient coding of natural scenes improves neural system identification

Qiu, Y.; Klindt, D. A.; Szatko, K. P.; Gonschorek, D.; Hoefling, L.; Schubert, T.; Busse, L.; Bethge, M.; Euler, T.

10.1101/2022.01.10.475663 — neuroscience — Posted on 2022-01-11

2745 Pan-genomic analysis of transcriptional modules across Salmonella Typhimurium reveals the regulatory landscape of different strains

Yuan, Y.; Seif, Y.; Rychel, K.; Yoo, R.; Chauhan, S. M.; Poudel, S.; Al-bulushi, T.; Palsson, B.; Sastry, A. V.

10.1101/2022.01.11.475931 — systems biology — Posted on 2022-01-11

2746 Pervasive conditional selection of driver mutations and modular epistasis networks in cancer

Iranzo, J.; Gruenhagen, G.; Calle-Espinosa, J.; Koonin, E. V.

10.1101/2022.01.10.475617 — cancer biology — Posted on 2022-01-11

2747 Alignment of spatial genomics and histology data using deep Gaussian processes

Jones, A.; Townes, F. W.; Li, D.; Engelhardt, B. E.

10.1101/2022.01.10.475692 — bioinformatics — Posted on 2022-01-11

2748 oCEM: Automatic detection and analysis of overlapping co-expressed gene modules

Nguyen, Q.-H.; Le, D.-H.

10.1101/2021.03.15.435373 — bioinformatics — Posted on 2022-01-11

2749 Using syncmers improves long-read mapping

Pellow, D.; Dutta, A.; Shamir, R.

10.1101/2022.01.10.475696 — bioinformatics — Posted on 2022-01-11

2750 A single-cell atlas reveals shared and distinct immune responses and metabolism during SARS-CoV-2 and HIV-1 infections

Pan, T.; Cao, G.; Tang, E.; Zhao, Y.; Penaloza-MacMaster, P.; Fang, Y.; Huang, J.

10.1101/2022.01.10.475725 — bioinformatics — Posted on 2022-01-11

2751 Estimating cell-type-specific gene co-expression networks from bulk gene expression data with an application to Alzheimer's disease

Su, C.; Zhang, J.; Zhao, H.

10.1101/2021.12.21.473558 — bioinformatics — Posted on 2022-01-11

2752 Optimized cell culture conditions promote ex-vivo manipulation and expansion of primitive hematopoietic stem cells for therapeutic gene editing.

Rai, R.; Vetharoy, W.; Naseem, A.; Steinberg, Z.; Thrasher, A. J.; Santilli, G.; Cavazza, A.

10.1101/2022.01.11.475795 — bioengineering — Posted on 2022-01-11

2753 A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection

Vazquez-Rodriguez, J. A.; Shaqour, B.; Guarch-Perez, C.; Choinska, E.; Riool, M.; Verleije, B.; Beyers, K.; Costantini, V. J. A.; Swieszkowski, W.; Zaat, S. A. J.; Cos, P.; Felici, A.; Ferrari, L.

10.1101/2022.01.10.475592 — bioengineering — Posted on 2022-01-11

2754 Structural predictions of the SNX-RGS proteins suggest they belong to a new class of lipid transfer proteins

Paul, B.; Weeratunga, S.; Tillu, V. A.; Hariri, H.; Henne, W. M.; Collins, B.

10.1101/2021.11.30.470681 — biochemistry — Posted on 2022-01-11

2755 H2A.Z deposition by SWR1C involves multiple ATP-dependent steps

Fan, J.; Moreno, A. T.; Baier, A. S.; Loparo, J. J.; Peterson, C. L.

10.1101/2022.01.11.475888 — biochemistry — Posted on 2022-01-11

2756 Membrane-active Polymers: NCMNP13-x, NCMNP21-x and NCMNP21b-x for Membrane Protein Structural Biology

Trinh, T. K. H.; Catalano, C.; Guo, Y.

10.1101/2022.01.10.475744 — biochemistry — Posted on 2022-01-11

2757 Multi-GBS: A massively multiplexed GBS-based protocol optimized for large, repetitive conifer genomes

Vallebueno-Estrada, M.; Steindl, S.; Akulova, V.; Riefler, J.; Slusarz, L.; Arizpe, A.; Swarts, K.

10.1101/2022.01.10.475685 — genomics — Posted on 2022-01-11

2758 Tumour mutations in long noncoding RNAs enhance cell fitness

Esposito, R.; Lanzos, A.; Polidori, T.; Guillen-Ramirez, H.; Merlin, B.; Mela, L.; Zoni, E.; Buechi, I.; Hovhannisyan, L.; McCluggage, F.; Medo, M.; Basile, G.; Meise, D. F.; Ramnarayanan, S.; Zwyssig, S.; Wenger, C.; Schwarz, K.; Vancura, A.; Bosch-Guiteras, N.; JuliKruithof-deo, M.; Zimmer, Y.; Medova, M.; Stroka, D.; Fox, A.; Johnson, R.

10.1101/2021.11.06.467555 — genomics — Posted on 2022-01-11

2759 Hypertrophic Chondrocytes Serve as a Reservoir for Marrow Associated Skeletal Stem and Progenitor Cells, Osteoblasts, and Adipocytes During Skeletal Development

Long, J. T.; Leinroth, A.; Liao, Y.; Ren, Y.; Mirando, A. J.; Nguyen, T.; Guo, W.; Sharma, D.; Rouse, D.; Wu, C.; Cheah, K.; Karner, C. M.; Hilton, M. J.

10.1101/2021.05.18.444731 — developmental biology — Posted on 2022-01-11

2760 Lung injury induces alveolar type 2 cell hypertrophy and polyploidy with implications for repair and regeneration

Weng, A.; Maciel-Herrerias, M.; Watanabe, S. J.; Flozak, A. S.; Welch, L.; Aillon, R. P.; Grant, R.; Han, S.; Dada, L.; HInchcliff, M.; Misharin, A.; Budinger, G. S.; Gottardi, C. J.

10.1101/2021.08.10.455833 — cell biology — Posted on 2022-01-11

2761 OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

Sturm, G.; Karan, K. R.; Monzel, A.; Santhanham, B. S.; Taivassalo, T.; Bris, C.; Duplaga, S. A.; Cross, M.; Towheed, A.; Higgins-Chen, A.; McManus, M. J.; Cardenas, A.; Lin, J.; Epel, E. S.; Rahman, S.; Vissing, J.; Grassi, B.; Levine, M.; Horvath, S.; Haller, R. G.; Lenaers, G.; Wallace, D. C.; Tavazoie, S.; Procaccio, V.; Kaufman, B. A.; Seifert, E. L.; Hirano, M.; Picard, M.

10.1101/2021.11.29.470428 — cell biology — Posted on 2022-01-11

2762 The RNA-Binding Protein SAM68 regulates cardiomyocyte differentiation by enhancing Gata4 translation

Dasti, A.; Antonelli, M. C.; Segura, M. A.; Armaos, A.; Bonnin, S.; Graf, T.; Paronetto, M. P.; Tian, T. V.; Bechara, E.; Tartaglia, G. G.

10.1101/2022.01.11.475875 — molecular biology — Posted on 2022-01-11

2763 Single-nucleus chromatin accessibility identifies a critical role for TWIST1 in idiopathic pulmonary fibrosis myofibroblast activity

Valenzi, E.; Bahudhanapati, H.; Tan, J.; Tabib, T.; Sullivan, D. I.; Sembrat, J.; Fan, L.; Chen, K.; Rojas, M.; Lafargue, A.; Felsher, D.; Tran, P. T.; Kass, D. J.; Lafyatis, R. A.

10.1101/2022.01.10.475117 — molecular biology — Posted on 2022-01-11

2764 A new class of protein sensor links spirochete pleomorphism, persistence, and chemotaxis

Muok, A. R.; Kurniyati, K.; Ortega, D. R.; Olsthoorn, F.; Mabrouk, A. S.; Li, C.; Briegel, A.

10.1101/2022.01.11.475842 — microbiology — Posted on 2022-01-11

2765 EnteroBase: Hierarchical clustering of 100,000s of bacterial genomes into species/sub-species and populations

Achtman, M.; Zhou, Z.; Charlesworth, J.; Baxter, L. A.

10.1101/2022.01.11.475882 — microbiology — Posted on 2022-01-11

2766 Adeno-associated Virus Receptor-binding: Flexible Domains and Alternative Conformations through cryo-Electron Tomography of AAV2 and AAV5 complexes

Hu, G.; Silveria, M. A.; Chapman, M. S.; Stagg, S. M.

10.1101/2022.01.10.475736 — microbiology — Posted on 2022-01-11

2767 Hydrogen production in an aerobic environment by Escherichia coli K-12

Metcalfe, G. D.; Sargent, F.; Hippler, M.

10.1101/2022.01.11.475878 — microbiology — Posted on 2022-01-11

2768 The dgc2 gene encoding di-guanylate cyclase suppresses both motility and biofilm formation in the filamentous cyanobacterium Leptolyngbya boryana.

Toida, K.; Kushida, W.; Yamamoto, H.; Yamamoto, K.; Uesaka, K.; Ihara, K.; Fujita, Y.; Iwasaki, H.

10.1101/2022.01.10.475764 — microbiology — Posted on 2022-01-11

2769 Efficient inactivation of African swine fever virus by a highly complexed iodine combined with compound organic acids

Qi, M.; Pan, L.; Gao, Y.; Li, M.; Wang, Y.; Li, L.-F.; Ji, C.; Sun, Y.; Qiu, H.-J.

10.1101/2022.01.10.475769 — microbiology — Posted on 2022-01-11

2770 Intracellular flow cytometry staining of antibody-secreting cells using phycoerythrin-conjugated antibodies: pitfalls and solutions

Renner, P.; Crone, M.; Kornas, M.; Pioli, K. T.; Pioli, P. D.

10.1101/2022.01.10.475671 — immunology — Posted on 2022-01-11

2771 Humanized CYP2C19 transgenic mouse as an animal model of cerebellar ataxia

Milosavljevic, F.; Brusini, I.; Atanasov, A.; Manojlovic, M.; Novalen, M.; Vucic, M.; Orescanin-Dusic, Z.; Brkljacic, J.; Miksys, S.; Miljevic, C.; Nikolic, A.; Blagojevic, D.; Wang, C.; Damberg, P.; Pesic, V.; Tyndale, R.; Ingelman-Sundberg, M.; Jukic, M. M.

10.1101/2022.01.10.475612 — neuroscience — Posted on 2022-01-11

2772 Local interactions between steady-state visually evoked potentials at nearby flickering frequencies

Liza, K.; Ray, S.

10.1101/2022.01.10.475604 — neuroscience — Posted on 2022-01-11

2773 Atlasing white matter and grey matter joint contributions to resting-state networks in the human brain

Nozais, V.; Forkel, S. J.; Petit, L.; Thiebaut de Schotten, M.; joliot, m.

10.1101/2022.01.10.475690 — neuroscience — Posted on 2022-01-11

2774 Bounded rational decision-making models suggest capacity-limited concurrent motor planning in human posterior parietal and frontal cortex

Schach, S.; Lindner, A.; Braun, D. A.

10.1101/2021.07.13.452019 — neuroscience — Posted on 2022-01-11

2775 Advancing motion denoising of multiband resting-state functional connectivity fMRI data

Williams, J. C.; Tubiolo, P. N.; Luceno, J. R.; Van Snellenberg, J. X.

10.1101/860635 — neuroscience — Posted on 2022-01-11

2776 Gut bacteria regulate the pathogenesis of Huntington's disease in Drosophila model

Chongtham, A.; Yoo, J. H.; Chin, T. M.; Akingbesote, N. D.; Huda, A.; Marsh, J. L.; Khoshnan, A.

10.1101/2021.08.12.456124 — neuroscience — Posted on 2022-01-11

2777 A theory of cortical map formation in the visual brain

Najafian, S.; Koch, E.; Teh, K.-L.; Jin, J.; Rahimi-Nasrabadi, H.; Zaidi, Q.; Kremkow, J.; Alonso, J.-M.

10.1101/2022.01.10.475662 — neuroscience — Posted on 2022-01-11

2778 Perceptual decisions and oculomotor responses rely on temporally distinct streams of evidence

Lisi, M.; Solomon, J. A.; Morgan, M. J.

10.1101/2020.03.31.018655 — neuroscience — Posted on 2022-01-11

2779 Establishment of a hypoxia ischemia reperfusion brain damagemodel in neonatal rats

fu, x.; zhang, t.; lin, w.; jiao, m.; zhang, z.; geng, j.; wei, q.; qi, a.; lin, k.; zheng, y.; fang, m.; li, p.; lin, z.

10.1101/2022.01.10.475606 — neuroscience — Posted on 2022-01-11

2780 Control of Leaf Width by the APC/CTAD1-WL1-NAL1 Pathway in Rice

You, J.; Xiao, W.; Zhou, Y.; Ye, L.; Yu, G.; Yu, P.; Zhang, X.; He, Z.; Xiang, Y.; Sang, X.; Li, Y.-F.; Zhao, F.; Ling, Y.; He, G.; Zhang, T.

10.1101/2022.01.10.475683 — plant biology — Posted on 2022-01-11

2781 Integrated cytometry with machine learning applied to high-content imaging of human kidney tissue for in-situ cell classification and neighborhood analysis

Winfree, S.; McNutt, A. T.; Khochare, S.; Borgard, T. J.; Barwinska, D.; Sabo, A. R.; Ferkowicz, M. J.; Williams, J. C.; Lingeman, J. E.; Gulbronson, C. J.; Kelly, K. J.; Sutton, T. A.; Dagher, P. C.; Eadon, M. T.; Dunn, K. W.; El-Achkar, T. M.

10.1101/2021.12.27.474025 — physiology — Posted on 2022-01-11

2782 Predicting cancer prognosis and drug response from the tumor microbiome

Hermida, L. C.; Gertz, E. M.; Ruppin, E.

10.1101/2020.07.21.214148 — cancer biology — Posted on 2022-01-11

2783 Probing the effect of glycosaminoglycan depletion on integrin interactions with collagen I fibrils in the native ECM environment.

Roth, J. A.; Hoop, C.; Williams, J.; Hayes, R.; Baum, J.

10.1101/2020.02.07.935932 — biophysics — Posted on 2022-01-11

2784 Anaplerotic flux into the Calvin-Benson cycle. Hydrogen isotope evidence for in vivo occurrence in C3 metabolism

Wieloch, T.; Augusti, A.; Schleucher, J.

10.1101/2021.07.30.454453 — biophysics — Posted on 2022-01-11

2785 FunOrder 2.0 - a fully automated method for the identification of co-evolved genes

Vignolle, G. A.; Mach, R. L.; Mach-Aigner, A. R.; Derntl, C.

10.1101/2022.01.10.475597 — bioinformatics — Posted on 2022-01-11

2786 Multi-cancer classification; an analysis of neural network complexity

Webber, J. W.; Elias, K. M.

10.1101/2022.01.10.475759 — bioinformatics — Posted on 2022-01-11

2787 Model-based hearing-restoration strategies for cochlear synaptopathy pathologies

Drakopoulos, F.; Vasilkov, V.; Osses Vecchi, A.; Wartenberg, T.; Verhulst, S.

10.1101/2022.01.10.475652 — bioengineering — Posted on 2022-01-11

2788 Sensitive protein detection using site-specifically oligonucleotide-conjugated nanobodies

Al-Amin, R. A.; Muthelo, P. M.; Abdurakhmanov, E.; Vincke, C.; Muyldermans, S.; Danielson, U. H.; Landegren, U.

10.1101/2022.01.10.475658 — bioengineering — Posted on 2022-01-11

2789 Micro topographical instruction of bacterial attachment, biofilm formation and in vivo host response

Romero, M.; Luckett, J.; Figueredo, G.; Carabelli, A.; Scurr, D.; Hook, A.; Dubern, J.-F.; Ison, E.; Xue, X.; da Silva, A. C.; Blackburn, C.; Carlier, A.; Vasilevich, A. S.; Sudarsanam, P.; Vermeulen, S.; Winkler, D. A.; Ghaemmaghami, A. M.; de Boer, J.; Williams, P.; Alexander, M. R.

10.1101/2020.10.10.328146 — bioengineering — Posted on 2022-01-11

2790 A Cartography of Differential Gene Methylation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Different Network Roles in the Protein-Protein Interactions Network Play Different, Biologically Relevant, Roles

Wilberforce, A.; Dalla Riva, G. V.

10.1101/2021.12.20.473375 — genomics — Posted on 2022-01-11

2791 Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission

Pooley, C. M.; Marion, G.; Doeschl-Wilson, A.

10.1101/2022.01.10.475628 — genetics — Posted on 2022-01-11

2792 Evaluation of methods incorporating biological function and GWAS summary statistics to accelerate discovery

Moore, A.; Marks, J.; Quach, B. C.; Guo, Y.; Bierut, L. J.; Gaddis, N. C.; Hancock, D. B.; Page, G. P.; Johnson, E. O.

10.1101/2022.01.10.475153 — genetics — Posted on 2022-01-11

2793 The megabase-scale crossover landscape is independent of sequence divergence

Lian, Q.; Solier, V.; Walkemeier, B.; Huettel, B.; Schneeberger, K.; mercier, r.

10.1101/2022.01.10.474936 — genetics — Posted on 2022-01-11

2794 Optimization of capture protocols across species targeting up to 32000 genes and their extension to pooled DNA

Mariac, C.; Bethune, K.; Oliveira de Aquino, S.; Abdelrahman, M.; Barnaud, A.; Billot, C.; Zekraoui, L.; Couderc, M.; Kane, N.; Carvalho Andrade, A.; Marraccini, P.; Kiwuka, C.; Albar, L.; Sabot, F.; Poncet, V.; Couvreur, T. L.; Berthouly-Salazar, C.; Vigouroux, Y.

10.1101/2022.01.10.474775 — evolutionary biology — Posted on 2022-01-11

2795 The genetic structure of a wild wheat population has remained associated with microhabitats over 36 years

Dahan-Meir, T.; Ellis, T. J.; Mafessoni, F.; Sela, H.; Manisterski, J.; Avivi-Ragolsky, N.; Raz, A.; Feldman, M.; Anikster, Y.; Nordborg, M.; Levy, A. A.

10.1101/2022.01.10.475641 — evolutionary biology — Posted on 2022-01-11

2796 Maternal transmission as a symbiont sieve, and the absence of lactation in male mammals

Constable, G. W. A.; Fagan, B.; Law, R.

10.1101/2022.01.10.475639 — evolutionary biology — Posted on 2022-01-11

2797 Ecosystem size-induced environmental fluctuations affect the temporal dynamics of community assembly mechanisms

Bier, R. L.; Vass, M.; Szekely, A. J.; Langenheder, S.

10.1101/2022.01.10.475621 — ecology — Posted on 2022-01-11

2798 Noise source importance in linear stochastic models of biological systems that grow, shrink, wander, or persist

Strang, A.; Huffmyer, W.; Rollins, H.; Abbott, K. C.; Thomas, P. J.

10.1101/2022.01.10.475598 — ecology — Posted on 2022-01-11

2799 Modelling and assessing additional transmission routes for porcine reproductive and respiratory syndrome virus: vehicle movements and feed ingredients

Galvis, J. A.; Corzo, C.; Machado, G.

10.1101/2021.07.26.453902 — ecology — Posted on 2022-01-11

2800 Optimum growth temperature declines with body size within fish species

Lindmark, M.; Ohlberger, J.; Gardmark, A.

10.1101/2021.01.21.427580 — ecology — Posted on 2022-01-11

2801 The Alzheimer's gene SORL1 is a key regulator of endosomal traffic and recycling in human neurons

Mishra, S.; Knupp, A.; Szabo, M.; Williams, C. A.; Kinoshita, C.; Hailey, D. W.; Wang, Y.; Young, J. E.

10.1101/2021.07.26.453861 — cell biology — Posted on 2022-01-11

2802 Library Preparation and Sequencing Platform Introduce Bias in Metagenomic-Based Characterizations of Microbiomes

Poulsen, C. S.; Ekstrom, C. T.; Aarestrup, F. M.; Pamp, S. J.

10.1101/592154 — microbiology — Posted on 2022-01-11

2803 Interactions between influenza A virus nucleoprotein and gene segment UTRs facilitate selective modulation of viral gene expression

Diefenbacher, M.; Tan, T. J. C.; Bauer, D. L. V.; Stadtmueller, B.; Wu, N. C.; Brooke, C. B.

10.1101/2022.01.09.475567 — microbiology — Posted on 2022-01-11

2804 Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

Yang, L.; Semmes, E. C.; Ovies, C.; Megli, C.; Permar, S.; Gilner, J. B.; Coyne, C. B.

10.1101/2021.03.29.437467 — immunology — Posted on 2022-01-11

2805 Prenatal stress programs behavioral pattern separation in adult mice

Rajendran, S.; Kaci, M.-L.; Ladeveze, E.; Abrous, N.; Koehl, M.

10.1101/2022.01.10.475616 — neuroscience — Posted on 2022-01-11

2806 A striatal plasticity that supports the long-term preservation of motor function in Parkinsonian mice.

Brague, J. C.; Seal, R. P.

10.1101/2022.01.10.475638 — neuroscience — Posted on 2022-01-11

2807 Enhancement of central norepinephrinergic neurotransmission contributes to inhibition of seizure-induced respiratory arrest by targeting the beta-1 adrenergic receptor (β1-AR) locating in the cardiomyocytes in the DBA/1 mouse SUDEP model

Lian, X.; Yu, Q.; Ma, H.; Gu, L.; Xu, Q.; Zhang, H.

10.1101/2022.01.10.475630 — neuroscience — Posted on 2022-01-11

2808 Short periods of bipolar anodal TDCS induce no instantaneous dose-dependent increase in cerebral blood flow in the targeted human motor cortex

Liu, M. L.; Karabanov, A. N.; Piek, M.; Petersen, E. T.; Thielscher, A.; Siebner, H. R.

10.1101/2022.01.10.475608 — neuroscience — Posted on 2022-01-11

2809 Accurate sex classification from neural responses to sexual stimuli

Putkinen, V. J.; Nazari-Farsani, S.; Karjalainen, T.; Santavirta, S.; Hudson, M.; Seppala, K.; Sun, L.; Karlsson, H.; Hirvonen, J.; Nummenmaa, L.

10.1101/2022.01.10.473972 — neuroscience — Posted on 2022-01-11

2810 Microstructural Impairments in a Topologically Distinct Prefrontal-Habenular Connection in Cocaine Addiction

King, S. G.; Gaudreault, P.-O.; Malaker, P.; Kim, J.-w.; Alia-Klein, N.; Xu, J.; Goldstein, R. Z.

10.1101/2022.01.10.475656 — neuroscience — Posted on 2022-01-11

2811 Collagen XVIII promotes breast cancer through EGFR/ErbB signaling and its ablation improves the efficacy of ErbB-targeting inhibitors

Devarajan, R.; Peltoketo, H.; Izzi, V.; Ruotsalainen, H. J.; Kauppila, S.; Vaisanen, M.-R.; Rask, G.; Martinez-Nieto, G.; Karppinen, S.-M.; Vaisanen, T.; Kaur, I.; Koivunen, J. P.; Sasaki, T.; Winqvist, R.; Warnberg, F.; Sund, M.; Pihlajaniemi, T. A.; Heljasvaara, R.

10.1101/2022.01.10.474416 — cancer biology — Posted on 2022-01-11

2812 Structure of the 5' untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune system via the human oligoadenylate synthase 1

Bignon, E.; Miclot, T.; Terenzi, A.; Barone, G.; Monari, A.

10.1101/2021.12.10.472066 — biophysics — Posted on 2022-01-11

2813 Multi-cancer classification; an analysis of neural network complexity

Webber, J. W.; Elias, K. M.

10.1101/2022.01.10.475759 — bioinformatics — Posted on 2022-01-11

2814 Experimental evidence of non-classical brain functions

Kerskens, C.; Lopez Perez, D.

10.1101/219931 — bioinformatics — Posted on 2022-01-11

2815 Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants

Qu, L.; Yi, Z.; Shen, Y.; Lin, L.; Chen, F.; Xu, Y.; Wu, Z.; Tang, H.; Zhang, X.; Tian, F.; Wang, C.; Xiao, X.; Dong, X.; Guo, L.; Lu, S.; Yang, C.; Tang, C.; Yang, Y.; Yu, W.; Wang, J.; Zhou, Y.; Huang, Q.; Yisimayi, A.; Cao, Y.; Wang, Y.; Zhou, Z.; Peng, X.; Wang, J.; Xie, X. S.; Wei, W.

10.1101/2021.03.16.435594 — immunology — Posted on 2022-01-11

2816 Frequent co-regulation of splicing and polyadenylation by RNA-binding proteins inferred with MAPP

Bak, M.; van Nimwegen, E.; Schmidt, R.; Zavolan, M.; Gruber, A. J.

10.1101/2022.01.09.475576 — systems biology — Posted on 2022-01-11

2817 Patterns of Structural Variation Define Prostate Cancer Across Disease States

Zhou, M.; Ko, M.; Hoge, A. C.; Luu, K.; Liu, Y.; Russell, M. L.; Hannon, W. W.; Zhang, Z.; Carrot-Zhang, J.; Beroukhim, R.; Van Allen, E.; Choudhury, A. D.; Nelson, P. S.; Freedman, M. L.; Taplin, M.-E.; Meyerson, M.; Viswanathan, S. R.; Ha, G.

10.1101/2022.01.09.475586 — genomics — Posted on 2022-01-11

2818 Immunoecology of species with alternative reproductive tactics and strategies

Lozano, G. A.; Ros, A. F. H.

10.1101/062083 — evolutionary biology — Posted on 2022-01-11

2819 Porcine intestinal innate lymphoid cells and lymphocyte spatial context revealed through single-cell RNA sequencing

Wiarda, J. E.; Trachsel, J. M.; Sivasankaran, S. K.; Tuggle, C. K.; Loving, C. L.

10.1101/2022.01.09.475571 — immunology — Posted on 2022-01-11

2820 Two subsets of circulating Ly6Clo monocytes distinguished by CD138 (syndecan-1) expression and Nr4a1 dependence in pristane-treated mice

Han, S.; Zhuang, H.; Arja, R. D.; Reeves, W. H.

10.1101/2022.01.09.475578 — immunology — Posted on 2022-01-11

2821 Experimenter sex modulates mouse biobehavioural and pharmacological responses

Georgiou, P.; Zanos, P.; Mou, T.-C. M.; An, X.; Gerhard, D. M.; Dryanovski, D. I.; Potter, L. E.; Highland, J. N.; Jenne, C. E.; Stewart, B. W.; Pultorak, K.; Yuan, P.; Powels, C. F.; Lovett, J.; Pereira, E. F. R.; Clark, S. M.; Tonelli, L. H.; Moaddel, R. F. R.; Zarate, C. A.; Duman, R. S.; Thompson, S. M.; Gould, T. D.

10.1101/2022.01.09.475572 — neuroscience — Posted on 2022-01-11

2822 Patterns of Saliency and Semantic Features Distinguish Gaze of Expert and Novice Viewers of Surveillance Footage

Peng, Y.; Burling, J. M.; Todorova, G. K.; Neary, C.; Pollick, F. E.; Lu, H.

10.1101/2022.01.09.475588 — neuroscience — Posted on 2022-01-11

2823 Estradiol mediates stress-susceptibility in the male brain

Georgiou, P.; Mou, T.-C. M.; Potter, L. E.; An, X.; Zanos, P.; Patton, M. S.; Pultorak, K. J.; Clark, S. M.; Ngyuyen, V.; Powels, C. F.; Prokai-Tartai, K.; Merchenthaler, I.; Prokai, L.; McCarthy, M. M.; Mathur, B. N.; Gould, T.

10.1101/2022.01.09.475485 — neuroscience — Posted on 2022-01-11

2824 Localized Synaptic Potentiation is Necessary and Sufficient for Context Fear Memory

Cardozo, L. M.; Dillingham, B. C.; Sousa, A. F.; Dang, W.; Job, N.; Yoo, E. J.; Ranamukhaarachchi, S. K.; Yuan, Q.; Mayford, M.

10.1101/2022.01.09.475530 — neuroscience — Posted on 2022-01-11

2825 Exploitation of neighbouring subsoil for nutrient acquisition under annual-perennial strip intercropping systems

Han, E.; Czaban, W.; Dresboll, D. B.; Thorup-Kristensen, K.

10.1101/2022.01.09.475506 — plant biology — Posted on 2022-01-11

2826 Xtrapol8: automatic elucidation of low-occupancy intermediate-states in crystallographic studies

De Zitter, E.; Coquelle, N.; Barends, T. R. M.; Colletier, J.-P.

10.1101/2022.01.09.475568 — biophysics — Posted on 2022-01-11

2827 Lemaitre's law and the spatial distributions of the cone photoreceptors in the retinas of vertebrates

Beygi, A.; Hatzikirou, H.

10.1101/2022.01.09.475540 — biophysics — Posted on 2022-01-11

2828 Single-cell network biology characterizes cell-type gene regulation for drug repurposing and phenotype prediction in Alzheimer's disease

Gupta, C.; Xu, J.; Jin, T.; Khullar, S.; Liu, X.; Alatkar, S.; Cheng, F.; Wang, D.

10.1101/2022.01.09.475548 — bioinformatics — Posted on 2022-01-11

2829 Quantitative Assessment of 3D Printed Blood Vessels Produced with J750™ Digital Anatomy™ for Suture Simulation

Marconi, S.; Mauri, V.; Negrello, E.; Pugliese, L.; Pietrabissa, A.; Auricchio, F.

10.1101/2022.01.09.475308 — bioengineering — Posted on 2022-01-11

2830 High-throughput direct screening of restriction endonuclease using microfluidic fluorescence-activated drop sorter based on SOS response in E. coli

Zhang, Y.; Agresti, J. J.; Zheng, Y.; Weitz, D. A.

10.1101/2022.01.09.475563 — bioengineering — Posted on 2022-01-11

2831 PCR-free, label-free detection of sequence-specific DNA with single-molecule sensitivity using in vitro N-hybrid system in microfluidic drops

Zhang, Y.; Weitz, D. A.

10.1101/2022.01.09.475569 — bioengineering — Posted on 2022-01-11

2832 A unique Thy-1-negative immuno-fibroblast population emerges as a key determinant of fibrotic outcomes to biomaterials

Abebayehu, D.; Pfaff, B. N.; Bingham, G. C.; Ghatti, S.; Miller, A.; Griffin, D. R.; Barker, T.

10.1101/2022.01.09.475583 — bioengineering — Posted on 2022-01-11

2833 Synthesis of cell-laden alginate microgels with tunable compositions based on microfluidic pico-injection technique

Zhang, Y.; Mao, A.; Mooney, D. J.; Weitz, D. A.

10.1101/2022.01.09.475570 — bioengineering — Posted on 2022-01-11

2834 A Tm4sf1-Marked Subpopulation of Endothelial Stem/Progenitor Cells Identified by Lung Single-Cell Omics of Pulmonary Arterial Hypertension

Hong, J.; Wong, B.; Huynh, C.; Tang, B.; Umar, S.; Yang, X.; Eghbali, M.

10.1101/2022.01.09.475566 — genomics — Posted on 2022-01-11

2835 Examining historical rates of leafcutting bee cell pathogens to establish baseline infectivity rates for alfalfa seed growers

Clements, J.; Haylett, M.; Nelson, B.; Walsh, D.

10.1101/2022.01.09.475547 — ecology — Posted on 2022-01-11

2836 Multiplex PCR reveals unique trends in pathogen and parasitoid infestations of alfalfa leafcutting brood cells.

Clements, J.; Haylett, M.; Nelson, B.; Shumate, S.; Young, N.; Bradford, B. Z.; Walsh, D.; Lamour, K.

10.1101/2022.01.09.475550 — ecology — Posted on 2022-01-11

2837 Mechanics of human embryo compaction

Firmin, J.; Ecker, N.; Danon, D. R.; Lange, V. B.; Turlier, H.; Patrat, C.; Maitre, J.-L.

10.1101/2022.01.09.475429 — developmental biology — Posted on 2022-01-11

2838 Integrated cyto-physiological and proteomic analyses reveal new insight into CMS mechanism in a novel upland cotton CMS line LD6A

Jie, Z.; Khan, A.; Bujin, Z.; Qiong, Z.; Ullah, N.; Xiangjun, K.; Yiding, L.; Liu, F.; Ruiyang, Z.

10.1101/2022.01.09.475591 — developmental biology — Posted on 2022-01-11

2839 Differential recognition and cytokine induction by the peptidorhamnomannan from Sporothrix brasiliensis and S. schenckii

Kischkel, B.; Lopes-Bezerra, L. M.; Taborda, C. P.; Joosten, L. A. B.; dos Santos, J. C.; Netea, M. G.

10.1101/2022.01.09.475552 — immunology — Posted on 2022-01-11

2840 Long-term two-photon imaging of spinal cord in freely behaving mice

Ju, F.; Jian, W.; Han, Y.; Huang, T.; Ke, J.; Liu, Z.; Cai, S.; Liu, N.; Wang, L.; Wei, P.

10.1101/2022.01.09.475306 — neuroscience — Posted on 2022-01-11

2841 Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X

Geng, J.; Li, W.; Tang, Y.; Gao, Y.; Lu, Y.; Li, P.; Li, X.; Wang, P.; Fan, Y.; Yang, Y.; Guo, Z.; Liu, X.

10.1101/2022.01.09.475579 — neuroscience — Posted on 2022-01-11

2842 OptiDiff: structural variation detection from single optical mapping reads

Akdel, M.; de Ridder, D.

10.1101/2022.01.08.475501 — bioinformatics — Posted on 2022-01-11

2843 Artificial Metabolic Networks: enabling neural computation with metabolic networks

Faure, L.; Mollet, B.; Liebermeister, W.; Faulon, J.-L.

10.1101/2022.01.09.475487 — systems biology — Posted on 2022-01-11

2844 Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome

Hornburg, D.; Ferdosi, S.; Hasan, M.; Tangeysh, B.; Brown, T. R.; Wang, T.; Elgierari, E. M.; Zhao, X.; Alavi, A.; Chu, J.; Figa, M.; Tao, W.; Wang, J.; Goldberg, M.; Xia, H.; Stolarczyk, C.; Batzoglou, S.; Siddiqui, A.; Farokhzad, O. C.

10.1101/2022.01.08.475439 — biophysics — Posted on 2022-01-11

2845 Validated method for automated glioma diagnosis from GFAP immunohistological images: a complete pipeline

Campo, A.; Fernandez-Flores, F.; Pumarola, M.

10.1101/2022.01.09.474689 — bioinformatics — Posted on 2022-01-11

2846 Validating amino acid variants in proteogenomics using sequence coverage by multiple reads

Levitsky, L. I.; Kuznetsova, K.; Kliuchnikova, A. A.; Ilina, I. Y.; Goncharov, A. O.; Lobas, A. A.; Ivanov, M. V.; Lazarev, V. N.; Ziganshin, R.; Gorshkov, M. V.; Moshkovskii, S.

10.1101/2022.01.08.475497 — bioinformatics — Posted on 2022-01-11

2847 A quantitative analysis of the similarities and differences of the HIV/FIV gag genome

Siu, C.; Cheng, X. W.

10.1101/2022.01.09.475545 — bioinformatics — Posted on 2022-01-11

2848 Engineering a 3D hydrogel system to study optic nerve head astrocyte morphology and behavior in response to glaucomatous insult

Strat, A. N.; Kirschner, A.; Yoo, H.; Singh, A.; Bague, T.; Li, H. N.; Herberg, S.; Ganapathy, P. S.

10.1101/2022.01.08.474536 — bioengineering — Posted on 2022-01-11

2849 RNA-sequencing of human post-mortem hypothalamus and nucleus accumbens identifies expression profiles associated with obesity.

Wake, C.; Schneider, J. A.; Stein, T. D.; Bregu, J.; Labadorf, A.; McKee, A.; De Jager, P. L.; Bennett, D. A.; Seshadri, S.; Myers, R. H.; DeStefano, A. L.

10.1101/2022.01.08.473382 — genomics — Posted on 2022-01-11

2850 Withdrawal from repeated nicotine vapor exposure increases somatic signs of physical dependence, anxiety-like behavior, and brain reward thresholds in adult male rats.

Martinez, M.; Uribe, K. P.; Garcia, V.; Lira, O.; Matos-Ocasio, F.; Negishi, K.; Khan, A. M.; O'Dell, L. E.; Mendez, I. A.

10.1101/2022.01.08.475467 — neuroscience — Posted on 2022-01-11

2851 Functional dissection of neural connectivity in generalized anxiety disorder

Steinhäuser, J. L.; Teed, A. R.; Al-Zoubi, O.; Hurlemann, R.; Chen, G.; Khalsa, S. S.

10.1101/2022.01.09.475543 — neuroscience — Posted on 2022-01-11

2852 Sub-second striatal dopamine dynamics assessed by simultaneous fast-scan cyclic voltammetry and fluorescence biosensor

Salinas, A. G.; Lee, J. O.; Augustin, S. M.; Zhang, S.; Patriarchi, T.; Tian, L.; Morales, M.; Mateo, Y.; Lovinger, D. M.

10.1101/2022.01.09.475513 — neuroscience — Posted on 2022-01-11

2853 Thalamo-Prefrontal Connectivity Correlates with Early Command-Following After Severe Traumatic Brain injury

Cosgrove, M. E.; Saadon, J. R.; Mikell, C. B.; Stefancin, P. L.; Alkadaa, L.; Wang, Z.; Saluja, S.; Servider, J.; Razzaq, B.; Huang, C.; Mofakham, S.

10.1101/2022.01.06.475131 — neuroscience — Posted on 2022-01-11

2854 PD1+ T-cells correlate with Nerve Fiber Density as a prognostic biomarker in patients with resected perihilar cholangiocarcinoma.

Tan, X.; Rosin, M.; Appinger, S.; Bednarsch, J.; Liu, D.; Wiltberger, G.; Garcia Vallejo, J.; Jang, S.; Czigany, Z.; Boroojerdi, S.; Gaisa, N.; Boor, P.; Buelow, R.; de Vos-Geelen, J.; Valkenburg-van Iersel, L.; Clahsen-van Groningen, M.; de Jong, E.; Groot Koerkamp, B.; Doukas, M.; Rocha, F.; Luedde, T.; Klinge, U.; Sivakumar, S.; Neumann, U.; Heij, L.

10.1101/2022.01.07.475344 — cancer biology — Posted on 2022-01-11

2855 Actin-microtubule dynamic composite forms responsive active matter with memory

Kucera, O.; Gaillard, J.; Guerin, C.; Thery, M.; Blanchoin, L.

10.1101/2022.01.10.475629 — biophysics — Posted on 2022-01-11

2856 Mode selection mechanism in traveling and standing waves revealed by Min wave reconstituted in artificial cells

Takada, S.; Yoshinaga, N.; Doi, N.; Fujiwara, K.

10.1101/2022.01.10.475761 — biophysics — Posted on 2022-01-11

2857 MicrogliaST: a web server for microglia spatiotemportal pattern analysis in normal and disordered brains

Xiaoling, Z.; Feng, L.; Guiyuan, T.; Li, Y.; Jiaxin, Z.; Wanqi, M.; Yu, Z.; Congxue, H.; Li, X.; Yinqi, X.; Chunlong, Z.

10.1101/2022.01.08.475469 — bioinformatics — Posted on 2022-01-11

2858 LinkExplorer: Predicting, explaining and exploring links in large biomedical knowledge graphs

Ott, S.; Barbosa-Silva, A.; Samwald, M.

10.1101/2022.01.09.475537 — bioinformatics — Posted on 2022-01-11

2859 Crystal structures of bacterial Small Multidrug Resistance transporter EmrE in complex with structurally diverse substrates

Kermani, A. A.; Burata, O. E.; Koff, B. B.; Koide, A.; Koide, S.; Stockbridge, R. B.

10.1101/2022.01.11.475788 — biochemistry — Posted on 2022-01-11

2860 TrpA1 is a shear stress mechanosensing channel regulating intestinal homeostasis in Drosophila

Gong, J.; Nirala, N. K.; Chen, J.; Wang, F.; Gu, P.; Wen, Q.; Ip, Y. T.; Xiang, Y.

10.1101/2022.01.10.475734 — developmental biology — Posted on 2022-01-11

2861 unc-37/Groucho and lsy-22/AES repress Wnt target genes in C. elegans asymmetric cell divisions

Bekas, K. N.; Phillips, B. T.

10.1101/2022.01.10.475695 — developmental biology — Posted on 2022-01-11

2862 Ccdc38 is required for sperm flagellum biogenesis and male fertility in mouse

Zhang, R.; Li, W.; Yuan, L.; Gao, F.; Wu, B.; Liu, C.; Wang, X.; Wang, L.; Xiao, S.; Chen, Y.; Wei, H.

10.1101/2022.01.10.475757 — developmental biology — Posted on 2022-01-11

2863 Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation

Ezzine, C.; Loison, L.; Bole-Feysot, C.; Dechelotte, P.; Coeffier, M.; Ribet, D.

10.1101/2022.01.09.475538 — cell biology — Posted on 2022-01-11

2864 Telomere elongation in the gut extends zebrafish lifespan

El Mai, M.; GUIGONIS, J.-M.; POURCHER, T.; Kang, D.; Yue, J.-X.; Ferreira, M. G.

10.1101/2022.01.10.475664 — cell biology — Posted on 2022-01-11

2865 Choice of medium affects PBMC quantification, cell size, and downstream respiratory analysis

Christensen, I. B.; Ribas, L. d. O. P.; Larsen, S.; Dela, F.; Gillberg, L.

10.1101/2022.01.10.475633 — cell biology — Posted on 2022-01-11

2866 Privacy-Preserving Federated Neural Network Learning for Disease-Associated Cell Classification

Sav, S.; Bossuat, J.-P.; Troncoso-Pastoriza, J. R.; Claassen, M.; Hubaux, J.-P.

10.1101/2022.01.10.475610 — cell biology — Posted on 2022-01-11

2867 Developmental regulation of mitotic chromosome formation revealed by condensin reporter mice

Taylor, G. C. A.; Macdonald, L. A.; Bui, M.; Scott, L.; Christodoulou, I.; Wills, J. C.; Papadopoulos, D.; Wood, A. J.

10.1101/2020.11.04.367847 — cell biology — Posted on 2022-01-11

2868 HP1β Chromo Shadow Domain facilitates H2A ubiquitination for BRCA1 recruitment at DNA double-strand breaks

Pandita, T.; Charaka, V. K.; Chakraborty, S.; Tsai, C.-L.; Wang, X.; Pandita, R.; Taineer, J.; Hunt, C. R.

10.1101/2022.01.11.475809 — cell biology — Posted on 2022-01-11

2869 Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

Baidya, M.; Chaturvedi, M.; Dwivedi-Agnihotri, H.; Ranjan, A.; Devost, D.; Namkung, Y.; Stepniewski, T. M.; Pandey, S.; Baruah, M.; Panigrahi, B.; Maharana, J.; Banerjee, R.; Selent, J.; Laporte, S.; Hebert, T. E.; Shukla, A. K.

10.1101/2022.01.11.475811 — biochemistry — Posted on 2022-01-11

2870 A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates

He, P.; Lim, K.; Sun, D.; Pett, J. P.; Jeng, Q.; Polanski, K.; Dong, Z.; Bolt, L.; Richardson, L.; Mamanova, L.; Dabrowska, M.; Wilbrey-Clark, A. L.; Madissoon, E.; Tuong, K. Z.; Dann, E.; Suo, C.; Goh, I.; He, X.; Barker, R. A.; Teichmann, S.; Marioni, J.; Meyer, K. B.; Rawlins, E. L.

10.1101/2022.01.11.474933 — developmental biology — Posted on 2022-01-11

2871 Hypoxia Dynamically Regulates DBC1 Ubiquitination and Stability by SIAH2 and OTUD5 in Breast Cancer Progression

Zhu, Y.; Liu, Q.; Luo, Q.; Feng, J.; Zhao, Y.; Liu, L.; Ma, B.; Cheng, H.; Zhang, J.; Zhao, T.; Mu, C.; Chen, L.; Lei, H.; Long, Y.; Su, J.; Chen, G.; Li, Y.; Chen, Q.

10.1101/2022.01.11.475808 — cell biology — Posted on 2022-01-11

2872 Cis-clustering of cadherin-23 controls the kinetics of cell-cell adhesion

Srinivas, C. S.; Singaraju, G. S.; Das, S.; Sagar, A.; Kumar, A.; Rakshit, S.

10.1101/2022.01.09.475209 — cell biology — Posted on 2022-01-11

2873 Oil Red O based method for Exosome Labelling and Detection

Bharati, S.; Anjaly, K.; Thoidingjam, S.; Tiku, A. B.

10.1101/2022.01.09.475514 — cell biology — Posted on 2022-01-11

2874 WNK kinases sense molecular crowding and rescue cell volume via phase separation

Boyd-Shiwarski, C. R.; Shiwarski, D. J.; Griffiths, S. E.; Beacham, R. T.; Norrell, L.; Morrison, D. E.; Wang, J.; Mann, J. R.; Tennant, W.; Anderson, E. N.; Franks, J.; Calderon, M.; Connolly, K. A.; Weaver, C. J.; Weckerly, C. C.; Pandey, U. B.; Donnelly, C. J.; Sun, D.; Rodan, A. R.; Subramanya, A. R.

10.1101/2022.01.10.475707 — cell biology — Posted on 2022-01-11

2875 Pericentriolar matrix integrity relies on cenexin and Polo-Like Kinase (PLK)1

Aljiboury, A. A.; Mujcic, A.; Curtis, E.; Cammerino, T.; Magny, D.; Lan, Y.; Bates, M.; Freshour, J.; Ahmed-Braimah, Y. H.; Hehnly, H.

10.1101/2022.01.09.475500 — cell biology — Posted on 2022-01-11

2876 Anti-thrombotic treatment enhances antibiotic efficiency in a humanized model of meningococcemia

Corre, J.-P.; Obino, D.; Nivoit, P.; Yatim, A.; Schmitt, T.; Dumenil, G.

10.1101/2022.01.10.475613 — pathology — Posted on 2022-01-11

2877 The dorsal hippocampus' role in context-based timing in rodents

De Corte, B. J.; Farley, S. J.; Heslin, K. A.; Parker, K. L.; Freeman, J. H.

10.1101/2022.01.10.475732 — neuroscience — Posted on 2022-01-11

2878 Reconstructing Kinetic Models for Dynamical Studies of Metabolism using Generative Adversarial Networks

Choudhury, S.; Moret, M.; Salvy, P.; Weilandt, D.; Hatzimanikatis, V.; Miskovic, L.

10.1101/2022.01.06.475020 — systems biology — Posted on 2022-01-11

2879 Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia

Wang, H.; Lu, J.; Alencastro, F.; Roberts, A.; Fiedor, J.; Carroll, P.; Eisenman, R.; Ranganathan, S.; Torbenson, M.; Duncan, A. W.; Prochownik, E. V.

10.1101/2021.08.05.455215 — cancer biology — Posted on 2022-01-11

2880 Simulation of foraging behavior using a decision-making agent with Bayesian and inverse Bayesian inference: Temporal correlations and power laws in displacement patterns

Shinohara, S.; Okamoto, H.; Manome, N.; Gunji, Y.; Nakajima, Y.; Moriyama, T.; Chung, U.-i.

10.1101/2021.06.08.447450 — animal behavior and cognition — Posted on 2022-01-11

2881 Day-night and seasonal variation of human gene expression across tissues

Wucher, V.; Sodaei, R.; Amador, R.; Irimia, M.; Guigo, R.

10.1101/2021.02.28.433266 — genomics — Posted on 2022-01-11

2882 The effects of epistasis and linkage on the invasion of locally beneficial mutations and the evolution of genomic islands

Pontz, M.; Bürger, R.

10.1101/2021.04.30.442097 — evolutionary biology — Posted on 2022-01-11

2883 No evidence for long-range male sex pheromones in two malaria mosquitoes

Poda, S. B.; Buatois, B.; Lapeyre, B.; Dormont, L.; Diabate, A.; Gnankine, O.; Dabire, R. K.; Roux, O.

10.1101/2020.07.05.187542 — ecology — Posted on 2022-01-11

2884 Superresolution microscopy reveals partial preassembly and subsequent bending of the clathrin coat during endocytosis

Mund, M.; Tschanz, A.; Wu, Y.-L.; Frey, F.; Mehl, J. L.; Kaksonen, M.; Avinoam, O.; Schwarz, U. S.; Ries, J.

10.1101/2021.10.12.463947 — cell biology — Posted on 2022-01-11

2885 The hippocampus as a sorter and reverberatory integrator of sensory inputs

Nomoto, M.; Murayama, E.; Ohno, S.; Okubo-Suzuki, R.; Muramatsu, S.-i.; Inokuchi, K.

10.1101/2022.01.10.475731 — neuroscience — Posted on 2022-01-11

2886 Closed-loop recruitment of striatal parvalbumin interneurons prevents the onset of compulsive behaviors

Mondragon-Gonzalez, S. L.; Schreiweis, C.; BURGUIERE, E.

10.1101/2022.01.10.475745 — neuroscience — Posted on 2022-01-11

2887 On Riemannian Geometries of Visual Space

Turski, J.

10.1101/2021.10.25.465820 — neuroscience — Posted on 2022-01-11

2888 A Programmable Ontology Encompassing the Functional Logic of the Drosophila Brain

Lazar, A. A.; Turkcan, M. K.; Zhou, Y.

10.1101/2021.12.28.474399 — neuroscience — Posted on 2022-01-11

2889 Alpha phase-amplitude tradeoffs predict visual perception

Fakche, C.; VanRullen, R.; Marque, P.; Dugue, L.

10.1101/2021.05.25.445552 — neuroscience — Posted on 2022-01-11

2890 TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through a transcriptional repression mechanism

Qi, H.; Luo, L.; Lu, C.; Chen, R.; Zhou, X.; Zhang, X.; Jia, Y.

10.1101/2022.01.10.475593 — neuroscience — Posted on 2022-01-11

2891 Uncertainty-guided learning with scaled prediction errors in the basal ganglia

Moeller, M.; Manohar, S.; Bogacz, R.

10.1101/2022.01.10.475599 — neuroscience — Posted on 2022-01-11

2892 Eye-hand coordination during online reach corrections is task-dependent

de Brouwer, A. J.; Spering, M.

10.1101/2021.06.13.448238 — neuroscience — Posted on 2022-01-10

2893 Recognition of HIV-1 capsid licenses innate immune response to viral infection

yoh, s. M.; Mamede, J.; Lau, D.; Ahn, N.; Sanchez, M. T.; Temple, J.; Tuckwell, A.; Fuchs, N. V.; Cianci, G.; Riva, L.; Curry, H.; Yin, X.; Gambut, S.; Simons, L. M.; Hultquist, J. F.; Koenig, R.; Xiong, Y.; Garcia-Sastre, A.; BÖcking, T.; Hope, T. J.; Chanda, S.

10.1101/2022.01.10.472699 — molecular biology — Posted on 2022-01-10

2894 Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface-active antimicrobial peptide-like region and a possible substrate-binding subdomain

Vazquez, R.; Seoane-Blanco, M.; Rivero-Buceta, V.; Ruiz, S.; van Raaij, M. J.; Garcia, P.

10.1101/2022.01.10.475687 — molecular biology — Posted on 2022-01-10

2895 Small uORFs favor translation re-initiation but do not protect mRNAs from nonsense-mediated decay

Russell, P. J.; Slivka, J. A.; Boyle, E. P.; Burghes, A. H. M.; Kearse, M. G.

10.1101/2022.01.10.475702 — molecular biology — Posted on 2022-01-10

2896 FMRP inhibits translation elongation independent of mRNA G-quadruplexes

Scarpitti, M. R.; Warrick, J. E.; Kearse, M. G.

10.1101/2022.01.10.475703 — molecular biology — Posted on 2022-01-10

2897 Exploring high-resolution cryo-ET and subtomogram averaging capabilities of contemporary DEDs

Obr, M.; Hagen, W. J.; Dick, R. A.; Yu, L.; Kotecha, A.; Schur, F. K.

10.1101/2022.01.10.475481 — molecular biology — Posted on 2022-01-10

2898 Impact of Nosema ceranae invasion on sucrose solution consumption, midgut epithelial cell structure, and lifespan of Apis cerana cerana workers

Long, Q.; Sun, M.; Fan, X.; Zhang, W.; Zhou, D.; Hu, Y.; Wang, Z.; Zhang, K.; Yu, K.; Zhao, H.; Song, Y.; Fu, Z.; Guo, R.; Chen, D.

10.1101/2022.01.09.475580 — molecular biology — Posted on 2022-01-10

2899 Strong SARS-CoV-2 N-specific CD8+ T immunity induced by engineered extracellular vesicles associates with protection from lethal infection in mice.

Ferrantelli, F.; Chiozzini, C.; Manfredi, F.; Leone, P.; Spada, M.; DiVirgilio, A.; Giovannelli, A.; Sanchez, M.; Cara, A.; Michelini, Z.; Federico, M.

10.1101/2022.01.10.475620 — microbiology — Posted on 2022-01-10

2900 Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2

Saunders, N.; Planas, D.; Bolland, W. H.; Rodriguez, C.; Fourati, S.; Buchrieser, J.; Planchais, C.; Prot, M.; Staropoli, I.; Guivel-Benhassine, F.; Porrot, F.; Veyer, D.; Pere, H.; Robillard, N.; Saliba, M.; Baidaliuk, A.; Seve, A.; Hocqueloux, L.; Prazuck, T.; Mouquet, H.; Simon-Loriere, E.; Bruel, T.; Pawlotsky, J.-M.; Schwartz, O.

10.1101/2022.01.07.475248 — microbiology — Posted on 2022-01-10

2901 Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro

Jonsdottir, H. R.; Siegrist, D.; Julien, T.; Padey, B.; Bouveret, M.; Terrier, O.; Pizzorno, A.; Huang, S.; Samby, K.; Wells, T.; Boda, B.; Rosa-Calatrava, M.; Engler, O.; Constant, S.

10.1101/2022.01.10.475377 — microbiology — Posted on 2022-01-10

2902 Differential response of Candida species morphologies and isolates to fluconazole and boric acid

Salama, O. E.; Gerstein, A. C.

10.1101/2022.01.09.475582 — microbiology — Posted on 2022-01-10

2903 Establishment of a transparent soil system to study Bacillus subtilis chemical ecology

Lozano-Andrade, C. N.; Nogueira, C. G.; Wibowo, M.; Kovacs, A. T.

10.1101/2022.01.10.475645 — microbiology — Posted on 2022-01-10

2904 The Salmonella transmembrane effector SteD hijacks AP1-mediated vesicular trafficking for delivery to antigen-loading MHCII compartments

Godlee, C.; Cerny, O.; Liu, M.; Blundell, S.; Gallagher, A. E.; Shahin, M.; Holden, D. W.

10.1101/2022.01.10.475600 — microbiology — Posted on 2022-01-10

2905 Visualization of SpoVAEa protein dynamics in dormant spores of Bacillus cereus and dynamic changes in their germinosomes and SpoVAEa during germination

Wang, Y.; Vischer, N. O. E.; Wekking, D.; Bogian, A.; Setlow, P.; BRUL, S.

10.1101/2022.01.10.475594 — microbiology — Posted on 2022-01-10

2906 Pilot scale study on UV-C inactivation of bacterial endospores and virus particles in whole milk: evaluation of system efficiency and product quality

Vashisht, P.; Pendyala, B.; Patras, A.; Vipul Sudhir Gopisetty, V.; Ravi, R.

10.1101/2022.01.07.475436 — microbiology — Posted on 2022-01-10

2907 Live imaging of Yersinia translocon formation and immune recognition in host cells

Rudolph, M.; Carsten, A.; Aepfelbacher, M.; Wolters, M.

10.1101/2022.01.10.475601 — microbiology — Posted on 2022-01-10

2908 Membrane interactions and uncoating of Aichi virus, a picornavirus that lacks a VP4

Kelly, J.; Swanson, J.; Newman, J.; Groppelli, E.; Stonehouse, N.; Tuthill, T. J.

10.1101/2022.01.10.475380 — microbiology — Posted on 2022-01-10

2909 RelCoVax(R), a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in mice

Phatarphekar, A.; Reddy, G. V.; Gokhale, A.; Karanam, G.; Kuchroo, P.; Shinde, K.; Masand, G.; Pagare, S.; Khadpe, N.; Pai, S. S.; Vijayan, V.; RL, R.; Reddy, K. P.; Rao, P.; Rao, S. H.; Ramana, V.

10.1101/2022.01.07.475330 — immunology — Posted on 2022-01-10

2910 Nrf2 attenuates the innate immune response after experimental myocardial infarction

Bromage, D. I.; Trevelin, S. C.; Huntington, J.; Yang, V.; Muthukumar, A.; Mackie, S.; Sawyer, G.; Zhang, X.; Santos, C.; Safinia, N.; Smyrnias, I.; Giacca, M.; Ivetic, A.; Shah, A.

10.1101/2022.01.10.475615 — immunology — Posted on 2022-01-10

2911 Molecular Structure Study on the Polyelectrolyte Properties of Actin Filaments

Bedoya, S. M.; Marucho, M.

10.1101/2022.01.07.475417 — neuroscience — Posted on 2022-01-10

2912 Anterior cingulate metabolite levels, memory, and inhibitory control in abstinent men and women with Alcohol Use Disorder

Oot, E. N.; Sawyer, K. S.; Oscar-Berman, M.; Luhar, R. B.; Jensen, J. E.; Silveri, M. M.

10.1101/2022.01.07.475448 — neuroscience — Posted on 2022-01-10

2913 Sex differences in the alcohol-mediated modulation of BLA network states

DiLeo, A.; Antonoudiou, P.; Ha, S.; Maguire, J.

10.1101/2022.01.07.475435 — neuroscience — Posted on 2022-01-10

2914 Two-photon patterned photostimulation with low-power, high-efficiency and reliable single-cell optogenetic control

Wang, Y.; Zheng, Y.; Xu, Y.; Li, R.; Zheng, Y.; Chen, J.; Li, X.-M.; Hu, H.; Duan, S.; Gong, W.; Si, K.

10.1101/2022.01.08.475477 — neuroscience — Posted on 2022-01-10

2915 Strong Aversive Conditioning Triggers a Long-Lasting Generalized Aversion

Ramos, R.; Wu, C.-H.; Turrigiano, G. G.

10.1101/2022.01.10.475691 — neuroscience — Posted on 2022-01-10

2916 Diversity of cave Phlebotomines (Diptera: Psychodidae) from a Colombian cave

Velazquez, M.; Stuckert, A. M. M.; Vivero, R.; Matute, D. R.

10.1101/2022.01.07.475242 — zoology — Posted on 2022-01-10

2917 The non-neutral, multi-level, phenotypic impact of synonymous mutations revealed through heterologous gene expression in human cells.

Picard, M. A. L.; Leblay, F.; Cassan, C.; Decourcelle, M.; Willemsen, A.; Bauffe, F.; Demange, A.; Bravo, I. G.

10.1101/2022.01.07.475042 — systems biology — Posted on 2022-01-10

2918 ARF small GTPases in the developmental function mediated by ARF regulators GNOM and VAN3

Adamowski, M.; Matijevic, I.; Friml, J.

10.1101/2022.01.07.475425 — plant biology — Posted on 2022-01-10

2919 Diurnal stomatal apertures and density ratios affect whole-canopy stomatal conductance, water-use efficiency and yield

GOSA, S.; Gebeyo, B. A.; Patil, R.; Mencia, R.; Moshelion, M.

10.1101/2022.01.06.475121 — plant biology — Posted on 2022-01-10

2920 Peptide-centric analyses of human plasma enable increased resolution of biological insights into non-small cell lung cancer relative to protein-centric analysis

Donovan, M. K. R.; Huang, Y.; Blume, J. E.; Wang, J.; Hornberg, D.; Mohtashemi, I.; Kim, S.; Ko, M.; Benz, R. W.; Platt, T. L.; Batzoglou, S.; Farokhzad, O. C.; Siddiqui, A.

10.1101/2022.01.07.475393 — cancer biology — Posted on 2022-01-10

2921 Radiofrequency ablation remodels the tumor microenvironment and promotes systemic immunomodulation in pancreatic cancer

Faraoni, E. Y.; Thosani, N. C.; O'Brien, B.; Strickland, L. N.; Mota, V. Y.; Chaney, J. K.; Cen, P.; Rowe, J.; Cardenas, J. C.; Poulsen, K. L.; Wray, C. J.; Bailey-Lundberg, J.

10.1101/2022.01.07.475451 — cancer biology — Posted on 2022-01-10

2922 Characterizing protein protonation microstates using Monte Carlo sampling

Khaniya, U.; Mao, J.; Wei, R.; Gunner, M.

10.1101/2022.01.07.475457 — biophysics — Posted on 2022-01-10

2923 Deviation from the Residue-Based Linear Free Energy Relationship Reveals a Non-Native Structure in Protein Folding

Fujinami, D.; Hayashi, S.; Kohda, D.

10.1101/2022.01.07.475459 — biophysics — Posted on 2022-01-10

2924 Quantification of salt stress in wheat leaves by Raman spectroscopy and machine learning

Kecoglu, I.; Sirkeci, M.; Sen, A.; Unlu, M. B.; Parlatan, U.; Guzelcimen, F.

10.1101/2022.01.07.475441 — biophysics — Posted on 2022-01-10

2925 Uncovering One-Dimensional Reaction Coordinate that Underlies Structure-Function Relationship of Proteins

Wu, S.; Li, H.; Ma, A.

10.1101/2022.01.08.475519 — biophysics — Posted on 2022-01-10

2926 A graph-embedded topic model enables characterization of diverse pain phenotypes among UK Biobank individuals

Wang, Y.; Benavides, R.; Diatchenko, L.; Grant, A.; Li, Y.

10.1101/2022.01.07.475444 — bioinformatics — Posted on 2022-01-10

2927 A visual atlas of genes tissue-specific pathological roles

Rai, P.; Jain, A.; Jha, N.; Sharma, D.; Kumar, S.; Raj, A.; Gupta, A.; Poonia, S.; Chawla, S.; Majumdar, A.; Chakraborty, T.; Ahuja, G.; Sengupta, D.

10.1101/2022.01.08.475476 — bioinformatics — Posted on 2022-01-10

2928 Systematic comparison of ranking aggregation methods for gene lists in experimental results

Wang, B.; Law, A.; Regan, T.; Parkinson, N.; Cole, J.; Russell, C. D.; Dockrell, D. H.; Gutmann, M. U.; Baillie, J. K.

10.1101/2022.01.09.475491 — bioinformatics — Posted on 2022-01-10

2929 Putative host-derived insertions in the genome of circulating SARS-CoV-2 variants

Yang, Y.; Dufault-Thompson, K.; Fontenele, R. S.; Jiang, X.

10.1101/2022.01.04.474799 — bioinformatics — Posted on 2022-01-10

2930 Retinal axial motion analysis and implications for real-time correction in human retinal imaging

Cai, Y.; Grieve, K.; Mece, P.

10.1101/2022.01.07.475424 — bioengineering — Posted on 2022-01-10

2931 Single-Cell Proteomics Study of Immune Cell Diversity by Quantitating 465 Proteins

Yang, L.; Liu, J.; Reddy, R.; Wang, J.

10.1101/2022.01.07.475463 — bioengineering — Posted on 2022-01-10

2932 Application of sequential cyclic compression on cancer cells in a flexible microdevice

Onal, S.; Alkaisi, M. M.; Nock, V.

10.1101/2022.01.07.475458 — bioengineering — Posted on 2022-01-10

2933 Fluorescence visualization of deep-buried hollow organs

Feng, Z.; Li, Y.; Chen, S.; Yu, X.; Ying, Y.; Zheng, J.; Wu, T.; Li, J.; Fan, X.; Zhang, D.; Qian, J.

10.1101/2022.01.07.475462 — bioengineering — Posted on 2022-01-10

2934 A simple bypass assay for DNA polymerases shows hypermutating variants associated with cancer show mechanistic differences in vitro

Crevel, G.; Kearsey, S.; Cotterill, S.

10.1101/2022.01.10.475213 — biochemistry — Posted on 2022-01-10

2935 Evaluation of an optimized protocol and Illumina ARTIC V4 primer pool for sequencing of SARS-CoV-2 using COVIDSeq™ and DRAGEN™ COVID Lineage App workflow

Clark, C. R.; Hardison, M. T.; Houdeshell, H. N.; Vest, A. C.; Whitlock, D. A.; Skola, D. D.; Koble, J. S.; Oberholzer, M.; Schroth, G. P.

10.1101/2022.01.07.475443 — genomics — Posted on 2022-01-10

2936 Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells

Barnada, S. M.; Isopi, A.; Tejada-Martinez, D.; Goubert, C.; Patoori, S.; Pagliaroli, L.; Tracewell, M.; Trizzino, M.

10.1101/2022.01.10.475682 — genomics — Posted on 2022-01-10

2937 Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumanniicomplex

Djahanschiri, B.; Di Venanzio, G.; Distel, J. S.; Breisch, J.; Dieckmann, M. A.; Goesmann, A.; Göttig, S.; Wilharm, G.; Averhoff, B.; Feldman, M. F.; Ebersberger, I.

10.1101/2022.01.10.475602 — genomics — Posted on 2022-01-10

2938 The genomic landscape of contemporary western Remote Oceanians

Arauna, L. R.; Bergstedt, J.; Choin, J.; Mendoza-Revilla, J.; Harmant, C.; Roux, M.; Mas-Sandoval, A.; Lemee, L.; Colleran, H.; Francois, A.; Valentin, F.; Cassar, O.; Gessain, A.; Quintana-Murci, L.; Patin, E.

10.1101/2022.01.10.475623 — genomics — Posted on 2022-01-10

2939 A pleiotropic chemoreceptor facilitates the functional coupling of pheromone production and perception

Vernier, C.; Zelle, k.; Leitner, N.; Liang, X.; Halloran, S.; Millar, J.; Ben-Shahar, Y.

10.1101/2022.01.10.475668 — genetics — Posted on 2022-01-10

2940 Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis

Astre, G.; Atlan, T.; Goshtchevsky, U.; Shapira, K.; Oron-Gottesman, A.; Levy, T.; Velan, A.; Levanon, E. Y.; Deelen, J.; Harel, I.

10.1101/2022.01.10.475524 — genetics — Posted on 2022-01-10

2941 Reexamining Waddington: Canalization and new mutations are not required for the evolution of genetic assimilation

Marzec, S. R.; Pelletier, K.; Chang, A. H.-P.; Dworkin, I.

10.1101/2022.01.09.475581 — evolutionary biology — Posted on 2022-01-10

2942 Seasonal variability in carbon:234thorium ratios of suspended and sinking particles in coastal Antarctic waters: Field data and modeling synthesis

Stukel, M. R.; Schofield, O. M. E.; Ducklow, H. W.

10.1101/2022.01.07.475468 — ecology — Posted on 2022-01-10

2943 Quantifying biological carbon pump pathways with a data-constrained mechanistic model ensemble approach

Stukel, M. R.; Decima, M.; Landry, M. R.

10.1101/2022.01.07.475464 — ecology — Posted on 2022-01-10

2944 SOX17 Is Not Required for the Derivation and Maintenance of Mouse Extraembryonic Endoderm Stem Cell Lines

Dong, X.; Ding, A.; Lin, J.

10.1101/2022.01.09.475525 — developmental biology — Posted on 2022-01-10

2945 TRF2 rescues pathogenic phenotypes in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs

Eguchi, A.; Torres-Bigio, S. I.; Koleckar, K.; Birnbaum, F.; Blau, H. M.

10.1101/2022.01.10.475653 — cell biology — Posted on 2022-01-10

2946 Assessing Comparative Microbiome Performance in Plant Cell Wall Deconstruction Using Multi-omics-Informed Network Analysis

Tom, L. M.; Aulitto, M.; Wu, Y.-W.; Gao, Y. W.; Deng, K.; Xiao, N.; Rodriguez, B. G.; Louime, C.; Northen, T. R.; Eudes, A.; Mortimer, J.; Adams, P. D.; Scheller, H.; Simmons, B. A.; Ceja-Navarro, J.; Singer, S. W.

10.1101/2022.01.07.475446 — microbiology — Posted on 2022-01-10

2947 Robust Working Memory through Short-Term Synaptic Plasticity

Kozachkov, L.; Tauber, J.; Lundqvist, M.; Brincat, S. L.; Slotine, J.-J.; Miller, E. K.

10.1101/2022.01.09.475558 — neuroscience — Posted on 2022-01-10

2948 Critical-like bistable dynamics in the resting-state human brain

Wang, S.; Arnulfo, G.; Myrov, V.; Siebenhühner, F.; Nobili, L.; Breakspear, M.; Palva, S.; Palva, J. M.

10.1101/2022.01.09.475554 — neuroscience — Posted on 2022-01-10

2949 Comparative cytogenomics reveals genome reshuffling and centromere repositioning in the legume tribe Phaseoleae

Montenegro, C.; Martins, L.; Bustamante, F. d. O.; Brasileiro-Vidal, A. C.; Pedrosa-Harand, A.

10.1101/2021.08.06.455448 — genomics — Posted on 2022-01-10

2950 Aging leads to DNA methylation alterations associated with loss of lineage fidelity and breast cancer in mammary luminal epithelial cells

Senapati, P.; Miyano, M.; Sayaman, R. W.; Basam, M.; Trac, C.; Leung, A.; LaBarge, M. A.; Schones, D. E.

10.1101/2020.06.26.170043 — genomics — Posted on 2022-01-10

2951 Efficient Estimation of Indirect Effects in Case-Control Studies Using a Unified Likelihood Framework

Satten, G. A.; Curtis, S. W.; Solis-Lemus, C.; Leslie, E. J.; Epstein, M.

10.1101/2021.07.16.452552 — genetics — Posted on 2022-01-10

2952 Correlation scan: identifying genomic regions that affect genetic correlations applied to fertility traits

Olasege, B. S.; Porto-Neto, L. R.; Tahir, M. S.; Gouveia, G. C.; Canovas, A.; Hayes, B.; Fortes, M.

10.1101/2021.11.05.467409 — genetics — Posted on 2022-01-10

2953 The costs and benefits of dispersal in small populations

Polechova, J.

10.1101/2021.12.16.472951 — evolutionary biology — Posted on 2022-01-10

2954 Genetic isolation by distance underlies color pattern divergence in red-eyed treefrogs (Agalychnis callidryas)

Clark, M. I.; Bradburd, G. S.; Akopyan, M.; Vega, A.; Rosenblum, E. B.; Robertson, J. M.

10.1101/2021.05.21.445051 — evolutionary biology — Posted on 2022-01-10

2955 Trade-offs between cost of ingestion and rate of intake drive defensive toxin use

Douglas, T. E.; Beskid, S. G.; Gernand, C. E.; Nirtaut, B. E.; Tamsil, K. E.; Fitch, R. W.; Tarvin, R. D.

10.1101/2021.07.23.453507 — evolutionary biology — Posted on 2022-01-10

2956 Multifunctional role of GPCR signaling in epithelial tube formation

Vishwakarma, V.; Le, T. P.; Chung, S.

10.1101/2022.01.06.475238 — developmental biology — Posted on 2022-01-10

2957 Analysis of conditional colocalization relationships and hierarchies from three-color microscopy images

Vega-Lugo, J.; da Rocha-Azevedo, B.; Dasgupta, A.; Touret, N.; Jaqaman, K.

10.1101/2021.06.16.448703 — cell biology — Posted on 2022-01-10

2958 Dynamic Turnover of PI4P and PI(4,5)P2 under Hypoxia Controls Electrostatic Plasma Membrane Targeting

Lu, J.; Dong, W.; Hammond, G. R.; Hong, Y.

10.1101/2022.01.07.475384 — cell biology — Posted on 2022-01-10

2959 Poly(rC)-binding protein 1 limits hepatitis C virus assembly and secretion

Cousineau, S. E.; Rheault, M.; Sagan, S. M.

10.1101/2021.02.28.433252 — microbiology — Posted on 2022-01-10

2960 EGCG-modified bone graft to modulate the recruitment of M1 macrophage and alleviate the forming of fibrous capsule

Yao, D.; JIN, S.

10.1101/2020.11.10.376590 — immunology — Posted on 2022-01-10

2961 Traveling waves in the prefrontal cortex during working memory

Bhattacharya, S.; Brincat, S. L.; Lundqvist, M.; Miller, E. K.

10.1101/2021.04.08.438959 — neuroscience — Posted on 2022-01-10

2962 Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

Bolkan, S.; Stone, I.; Pinto, L.; Ashwood, Z.; Garcia, J.; Herman, A.; Singh, P.; Bandi, A.; Cox, J.; Zimmerman, C.; Cho, J.; Engelhard, B.; Pillow, J.; Witten, I.

10.1101/2021.07.23.453573 — neuroscience — Posted on 2022-01-10

2963 Behavioral and postural analyses establish sleep-like states for mosquitoes that can impact host landing and blood feeding

Ajayi, O. M.; Marlman, J. M.; Gleitz, L. A.; Smith, E. S.; Piller, B. D.; Krupa, J. A.; Vinauger, C.; Benoit, J. B.

10.1101/2021.11.11.467918 — physiology — Posted on 2022-01-10

2964 Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Cancer

Gupta, P.; Strange, K.; Telange, R.; Guo, A.; Hatch, H.; Sobh, A.; Elie, J.; Carter, A. M.; Totenhagen, J.; Tan, C.; Sonawane, Y. A.; Neuzil, J.; Natarajan, A.; Ovens, A. J.; Oakhill, J. S.; Wiederhold, T.; Pacak, K.; Ghayee, H. K.; Meijer, L.; Reddy, S.; Bibb, J. A.

10.1101/2022.01.09.475410 — cancer biology — Posted on 2022-01-10

2965 Changes in blood cell deformability in Chorea-Acanthocytosis and effects of treatment with dasatinib or lithium

Reichel, F.; Kraeter, M.; Peikert, K.; Glass, H.; Rosendahl, P.; Herbig, M.; Prieto, A. R.; Kihm, A.; Kaestner, L.; Hermann, A.; Guck, J.

10.1101/2021.12.16.472921 — biophysics — Posted on 2022-01-10

2966 The β-lactam Ticarcillin is a Staphylococcus aureus UDP-N-acetylglucosamine 2-epimerase binder.

de Azevedo, E. C.; Nascimento, A. S.

10.1101/2021.11.05.467346 — biophysics — Posted on 2022-01-10

2967 Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

Reed, B. D.; Meyer, M. J.; Abramzon, V.; Ad, O.; Adcock, P.; Ahmad, F. R.; Alppay, G.; Ball, J. A.; Beach, J.; Belhachemi, D.; Bellofiore, A.; Bellow, M.; Felipe Beltran, J.; Betts, A.; Wadud Bhuiya, M.; Blacklock, K.; Boer, R.; Boisvert, D.; Brault, N. D.; Buxbaum, A.; Caprio, S.; Choi, C.; Christian, T. D.; Clancy, R.; Clark, J.; Connolly, T.; Fink Croce, K.; Cullen, R.; Davey, M.; Davidson, J.; Elshenawy, M. M.; Ferrigno, M.; Frier, D.; Gudipati, S.; Hamill, S.; He, Z.; Hosali, S.; Huang, H.; Huang, L.; Kabiri, A.; Kriger, G.; Lathrop, B.; Li, A.; Lim, P.; Liu, S.; Luo, F.; Lv, C.; Ma, X.;

10.1101/2022.01.04.475002 — biophysics — Posted on 2022-01-10

2968 Identification of a phage display-derived peptide interacting with the N-terminal region of Factor VII activating protease (FSAP) enables characterization of zymogen activation.

Seidl, S.; Nielsen, N. V.; Etscheid, M.; Haug, B.-E.; Stensland, M.; Thiede, B.; Declerck, P.; Loset, G.; Kanse, S. M.

10.1101/2022.01.09.475526 — biochemistry — Posted on 2022-01-09

2969 RNA binding to human METTL3-METTL14 restricts N6-deoxyadenosine methylation of DNA in vitro

Qi, S.; Mota, J.; Chan, S.-H.; Villarreal, J.; Dai, N.; Arya, S.; Hromas, R. A.; Rao, M. K.; Correa, I. R.; Gupta, Y. K.

10.1101/2022.01.08.475504 — biochemistry — Posted on 2022-01-09

2970 Chromosome-level genome assembly and annotation of two lineages of the ant Cataglyphis hispanica: steppingstones towards genomic studies of hybridogenesis and thermal adaptation in desert ants

Darras, H.; de Souza Araujo, N.; Baudry, L.; Guiglielmoni, N.; Lorite, P.; Marbouty, M.; Rodriguez, F.; Arkhipov, I.; Koszul, R.; Flot, J.-F.; Aron, S.

10.1101/2022.01.07.475286 — genomics — Posted on 2022-01-09

2971 Cancer-driving mutations are enriched in genic regions intolerant to germline variation

Vitsios, D.; Dhindsa, R. S.; Mitchell, J.; Matelska, D.; Zou, Z.; Armenia, J.; Wang, Q.; Sidders, B.; Harper, A. R.; Petrovski, S.

10.1101/2022.01.07.475416 — genomics — Posted on 2022-01-09

2972 A numerical framework for genetic hitchhiking in populations of variable size

Friedlander, E.; Steinruecken, M.

10.1101/2021.03.25.437048 — genetics — Posted on 2022-01-10

2973 Fixation dynamics of beneficial alleles in prokaryotic polyploid chromosomes and plasmids

Santer, M.; Kupczok, A.; Dagan, T.; Uecker, H.

10.1101/2022.01.07.475421 — evolutionary biology — Posted on 2022-01-09

2974 Repeated origins, gene flow, and allelic interactions of herbicide resistance mutations in a widespread agricultural weed

Kreiner, J. M.; Sandler, G.; Stern, A. J.; Tranel, P. J.; Weigel, D.; Stinchcombe, J. R.; Wright, S. I.

10.1101/2021.05.10.443516 — evolutionary biology — Posted on 2022-01-10

2975 Influence of Nesting Material Composition on Tick Tube Use by Peromyscus leucopus

Mandli, J.; Ring, S. E.; Paskewitz, S. M.

10.1101/2022.01.07.475426 — ecology — Posted on 2022-01-09

2976 Isolation and Characterization of Extracellular Vesicles from the Fungal Phytopathogen Colletotrichum higginsianum

Rutter, B. D.; Chu, T.-T.-H.; Zajt, K. K.; Dallery, J.-F.; O'Connell, R. J.; Innes, R. W.

10.1101/2022.01.07.475419 — cell biology — Posted on 2022-01-09

2977 Liquid-liquid phase separation of the chromosomal passenger complex drives parallel bundling of midzone microtubules

Niedzialkowska, E.; Truong, T. M.; Eldredge, L. A.; Redemann, S.; Chretien, D.; Stukenberg, T.

10.1101/2022.01.07.475460 — cell biology — Posted on 2022-01-09

2978 The EBNA2-EBF1 complex promotes oncogenic MYC expression levels and metabolic processes required for cell cycle progression of Epstein-Barr virus-infected B cells

Beer, S.; Wange, L. E.; Zhang, X.; Kuklik-Roos, C.; Enard, W.; Hammerschmidt, W.; Scialdone, A.; Kempkes, B.

10.1101/2021.12.29.474426 — molecular biology — Posted on 2022-01-10

2979 Identification of domestic cat hepadnavirus from a cat blood sample in Japan

Takahashi, K.; Kaneko, Y.; Shibanai, A.; Yamamoto, S.; Katagiri, A.; Osuga, T.; Inoue, Y.; Kuroda, K.; Tanabe, M.; Okabayashi, T.; Naganobu, K.; Minobe, I.; Saito, A.

10.1101/2022.01.09.475482 — microbiology — Posted on 2022-01-09

2980 A single amino acid substitution in PB1 of pandemic H1N1 with A/Ann Arbor/6/60 master donor virus mutations as a novel live-attenuated influenza virus vaccine

Nogales, A.; Steel, J.; Liu, W.-C.; Lowen, A. C.; Rodriguez, L.; Chiem, K.; Cox, A.; Garcia-Sastre, A.; Albrecht, R.; Dewhurst, S.; Martinez-Sobrido, L.

10.1101/2022.01.07.475442 — microbiology — Posted on 2022-01-09

2981 Polymer-directed inhibition of reversible to irreversible attachment prevents Pseudomonas aeruginosa biofilm formation

Carabelli, A.; Dubern, J.-F.; Papangeli, M.; Farthing, N. E.; Sanni, O.; Heeb, S.; Hook, A.; Alexander, M. R.; Williams, P.

10.1101/2022.01.08.475475 — microbiology — Posted on 2022-01-09

2982 Targeting Host PIM Protein Kinases Reduces Mayaro Virus Replication

Sugasti-Salazar, M.; Campos, D.; Valdes-Torres, P.; Galan-Jurado, P. E.; Gonzalez-Santamaria, J.

10.1101/2022.01.09.475559 — microbiology — Posted on 2022-01-09

2983 Sequential sampling from memory underlies action selection during abstract decision making

Shushruth, S.; Zylberberg, A.; Shadlen, M. N.

10.1101/2021.04.30.442176 — neuroscience — Posted on 2022-01-10

2984 Decoding the Information Structure Underlying the Neural Representation of Concepts

Fernandino, L.; Tong, J.-Q.; Conant, L. L.; Humphries, C. J.; Binder, J. R.

10.1101/2021.03.16.435524 — neuroscience — Posted on 2022-01-10

2985 Cut-and-Paste DNA Insertion with Engineered Type V-K CRISPR-associated Transposases

Tou, C. J.; Orr, B.; Kleinstiver, B. P.

10.1101/2022.01.07.475005 — synthetic biology — Posted on 2022-01-09

2986 Oncogenic role of a developmentally regulated NTRK2 splice variant

10.1101/2022.01.07.475392 — cancer biology — Posted on 2022-01-09

2987 Lipid nanoparticles delivering constitutively active STING mRNA as a novel anti-cancer therapeutic approach

Liu, W.; Alameh, M.-G.; Yang, J. F.; Xu, J. R.; Lin, P. J.; Tam, Y. K.; Weissman, D.; You, J.

10.1101/2022.01.08.475499 — bioengineering — Posted on 2022-01-09

2988 Intravenous gene transfer throughout the brain of infant Old World primates using AAV

Chuapoco, M. R.; Flytzanis, N.; Goeden, N.; Octeau, J. C.; Roxas, K. M.; Chan, K. Y.; Scherrer, J.; Winchester, J.; Blackburn, R. J.; Campos, L. J.; Arokiaraj, C. M.; Miles, T. F.; Jang, M. J.; Vendemiatti, J.; Deverman, B. E.; Pickel, J.; Fox, A. S.; Gradinaru, V.

10.1101/2022.01.08.475342 — bioengineering — Posted on 2022-01-09

2989 HDX-MS performed on BtuB in E. coli outer membranes delineates the luminal domain's allostery and unfolding upon B12 and TonB binding

Zmyslowski, A. M.; Baxa, M. C.; Gagnon, I. A.; Sosnick, T. C.

10.1101/2022.01.07.475440 — biochemistry — Posted on 2022-01-09

2990 Visual threats reduce blood-feeding and trigger escape responses in Aedes aegypti mosquitoes.

Wynne, N. E.; Chandrasegaran, K.; Fryzlewicz, L.; Vinauger, C.

10.1101/2022.01.08.475512 — animal behavior and cognition — Posted on 2022-01-10

2991 Sensitive detection of DNA contamination in tumor samples via microhaplotypes

Whitty, B.; Thompson, J. F.

10.1101/2020.12.18.423488 — genomics — Posted on 2022-01-10

2992 An NMR fingerprint matching approach for the identification and structural re-evaluation of Pseudomonas lipopeptides.

De Roo, V.; Verleysen, Y.; Kovacs, B.; De Vleeschouwer, M.; Girard, L.; Hofte, M.; De Mot, R.; Madder, A.; Geudens, N.; Martins, J. C.

10.1101/2022.01.07.475420 — microbiology — Posted on 2022-01-09

2993 Bacterial lifestyle switch in response to algal metabolites

Barak-Gavish, N.; Dassa, B.; Kuhlisch, C.; Nussbaum, I.; Rosenberg, G.; Avraham, R.; Vardi, A.

10.1101/2022.01.10.475657 — microbiology — Posted on 2022-01-10

2994 Potent protease inhibitors of deadly lagoviruses: rabbit hemorrhagic disease virus and European brown hare syndrome virus

Perera, K. D.; Johnson, D. K.; Lovell, S.; Groutas, W.; Chang, K.-O.; Kim, Y.

10.1101/2022.01.10.474982 — microbiology — Posted on 2022-01-10

2995 Co-localization of different neurotransmitter transporters on synaptic vesicles is sparse except of VGLUT1 and ZnT3

Upmanyu, N.; Jin, J.; Emde, H. v. d.; Ganzella, M.; Boesche, L.; Malviya, V. N.; Zhuleku, E.; Politi, A.; Ninov, M.; Silbern, I.; Leutenegger, M.; Urlaub, H.; Riedel, D.; Preobraschenski, J.; Milosevic, I.; Hell, S.; Jahn, R.; Sambandan, S.

10.1101/2021.06.30.449903 — neuroscience — Posted on 2022-01-10

2996 Molecular basis of SARS-CoV-2 Omicron variant receptor engagement and antibody evasion and neutralization

Hong, Q.; Han, W.; Li, J.; Xu, S.; Wang, Y.; Li, Z.; Wang, Y.; Zhang, C.; Huang, Z.; Cong, Y.

10.1101/2022.01.10.475532 — biochemistry — Posted on 2022-01-10

2997 A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

Yengo, L.; Vedantam, S.; Marouli, E.; Sidorenko, J.; Bartell, E.; Sakaue, S.; Graff, M.; Eliasen, A. U.; Jiang, Y.; Raghavan, S.; Miao, J.; Arias, J. D.; Mukamel, R. E.; Spracklen, C. N.; Yin, X.; Chen, S.-H.; Ferreira, T.; Ji, Y.; Karedera, T.; Lull, K.; Lin, K.; Malden, D. E.; Medina-Gomez, C.; Machado, M.; Moore, A.; Rueger, S.; GIANT Consortium - Height Working Group, ; 23andMe Research Team, ; VA Million Veteran Program, ; DiscovEHR (DiscovEHR and MyCode Community Health Initiative), ; eMERGE (Electronic Medical Records and Genomics Network), ; Lifelines Cohort Study, ; Regeneron Ge

10.1101/2022.01.07.475305 — genetics — Posted on 2022-01-10

2998 A natural mutator allele shapes mutation spectrum variation in mice

Sasani, T. A.; Ashbrook, D. G.; Beichman, A. C.; Lu, L.; Palmer, A. A.; Williams, R. W.; Pritchard, J. K.; Harris, K.

10.1101/2021.03.12.435196 — genetics — Posted on 2022-01-10

2999 Transcriptome-based phylogeny of the semi-aquatic bugs (Hemiptera: Heteroptera: Gerromorpha) reveals patterns of lineage expansion in a series of new adaptive zones

Armisen, D.; Viala, S.; da Rocha Silva Cordeiro, I.; Crumeire, A. J. J.; Hendaoui, E.; le Bouquin, A.; Duchemin, W.; Santos, E.; Toubiana, W.; Vargas-Lowman, A.; Burguez Floriano, C. F.; Polhemus, D. A.; Wang, Y.-H.; Rowe, L.; Moreira, F. F. F.; Khila, A.

10.1101/2022.01.08.475494 — evolutionary biology — Posted on 2022-01-10

3000 Genetic integration of behavioural and endocrine components of the stress response

Houslay, T. M.; Earley, R. L.; White, S. J.; Lammers, W.; Grimmer, A. J.; Travers, L.; Johnson, E.; Young, A. J.; Wilson, A. J.

10.1101/770586 — evolutionary biology — Posted on 2022-01-10

3001 Frequency-dependent hybridization contributes to habitat segregation in monkeyflowers

Toll, K.; Lowry, D.

10.1101/2021.08.21.457231 — ecology — Posted on 2022-01-10

3002 How to describe and measure phenology? An investigation on the diversity of metrics using phenology of births in large herbivores

Thel, L.; Chamaille-Jammes, S.; Bonenfant, C.

10.1101/2021.05.17.444418 — ecology — Posted on 2022-01-10

3003 Single-cell Transcriptomic Profiling Unveils Cardiac Cell-type Specific Response to Maternal Hyperglycemia Underlying the Risk of Congenital Heart Defects

Manivannan, S.; Mansfield, C.; Zhang, X.; Kodigepalli, K. M.; Majumdar, U.; Garg, V.; Basu, M.

10.1101/2021.05.28.446177 — developmental biology — Posted on 2022-01-10

3004 Dynamic Turnover of PI4P and PI(4,5)P2 under Hypoxia Controls Electrostatic Plasma Membrane Targeting

Lu, J.; Dong, W.; Hammond, G. R.; Hong, Y.

10.1101/2022.01.07.475384 — cell biology — Posted on 2022-01-09

3005 Increased resolution in the face of conflict: phylogenomics of the Neotropical bellflowers (Campanulaceae: Lobelioideae), a rapid plant radiation

Lagomarsino, L. P.; Frankel, L.; Uribe-Convers, S.; Antonelli, A.; Muchhala, N.

10.1101/2022.01.09.475565 — evolutionary biology — Posted on 2022-01-09

3006 Antibiotic action revealed by real-time imaging of the mycobacterial membrane

Wuo, M. G.; Dulberger, C. L.; Brown, R. A.; Sturm, A.; Ultee, E.; Bloom-Ackermann, Z.; Choi, C.; Garner, E. C.; Briegel, A.; Hung, D. T.; Rubin, E. J.; Kiessling, L. L.

10.1101/2022.01.07.475452 — microbiology — Posted on 2022-01-09

3007 Interactions between influenza A virus nucleoprotein and gene segment UTRs facilitate selective modulation of viral gene expression

Diefenbacher, M.; Tan, T. J. C.; Bauer, D. L. V.; Stadtmueller, B.; Wu, N. C.; brooke, c.

10.1101/2022.01.09.475567 — microbiology — Posted on 2022-01-09

3008 Trade-Offs Between Hepatic Host Defense and Metabolic Programs Underlie Sex-Biased Diseases

Nikkanen, J.; Leong, Y. A.; Krause, W. C.; Dermadi, D.; Maschek, J. A.; Van Ry, T.; Cox, J.; Weiss, E.; Gokcumen, O.; Chawla, A.; Ingraham, H.

10.1101/2022.01.07.475423 — physiology — Posted on 2022-01-10

3009 Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain

Fernandez-Castaneda, A.; Lu, P.; Geraghty, A. C.; Song, E.; Lee, M.-H.; Wood, J.; Yalcin, B.; Taylor, K. R.; Dutton, S.; Acosta-Alvarez, L.; Ni, L.; Contreras-Esquivel, D.; Gehlhausen, J. R.; Klein, J.; Lucas, C.; Mao, T.; Silva, J.; Pena-Hernandez, M.; Tabachnikova, A.; Takahashi, T.; Tabacof, L.; Tosto-Mancuso, J.; Breyman, E.; Kontorovich, A.; McCarthy, D.; Quezado, M.; Hefti, M.; Perl, D.; Folkerth, R.; Putrino, D.; Nath, A.; Iwasaki, A.; Monje, M.

10.1101/2022.01.07.475453 — neuroscience — Posted on 2022-01-10

3010 Membrane tension propagation couples axon growth and collateral branching

Shi, Z.; Innes-Gold, S.; Cohen, A. E.

10.1101/2022.01.09.475560 — neuroscience — Posted on 2022-01-10

3011 Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis

Feilen, L. P.; Chen, S.-Y.; Fukumori, A.; Feederle, R.; Zacharias, M.; Steiner, H.

10.1101/2022.01.10.475655 — biochemistry — Posted on 2022-01-10

3012 Purification of synchronized E. coli transcription elongation complexes by reversible immobilization on magnetic beads

Kelly, S. L.; Szyjka, C. E.; Strobel, E. J.

10.1101/2022.01.10.475675 — biochemistry — Posted on 2022-01-10

3013 Free diffusion of PI(4,5)P2 in the plasma membrane in the presence of high density effector protein complexes

Pacheco, J.; Cassidy, A. C.; Zewe, J. P.; Wills, R. C.; Hammond, G. R.

10.1101/2022.01.07.475414 — cell biology — Posted on 2022-01-09

3014 NOX4 inhibition promotes the remodeling of dystrophic muscle

Hammers, D. W.

10.1101/2022.01.08.475493 — cell biology — Posted on 2022-01-10

3015 BML-257, a small molecule that protects against drug induced liver injury in zebrafish

Jagtap, U.; Basu, S.; Lokhande, L.; Bharti, N.; Sachidanandan, C.

10.1101/2022.01.09.475146 — molecular biology — Posted on 2022-01-09

3016 RAB18 is a key regulator of GalNAc conjugated siRNA induced silencing in Hep3B cells

Lu, J.; Swearingen, E.; Hardy, M.; Collins, P.; Wu, B.; Yuan, E.; Lu, D.; Li, C.-M. K.; Wang, S.; Ollmann, M.

10.1101/2022.01.07.475411 — molecular biology — Posted on 2022-01-09

3017 The Cryo-EM Structures of two Amphibian Antimicrobial Cross-β Amyloid Fibrils

Bücker, R.; Seuring, C.; Cazey, C.; Veith, K.; Garcia-Alai, M.; Grünewald, K.; Landau, M.

10.1101/2022.01.08.475498 — molecular biology — Posted on 2022-01-09

3018 HIF-1α Contributes to the Progression of Chronic Obstructive Pulmonary Disease

Zhang, K.; Zhou, F.; Zhu, C.; Yuan, L.; Li, D.; Wang, J.; Lu, W.

10.1101/2022.01.09.472256 — molecular biology — Posted on 2022-01-09

3019 Metabolic phenotyping of marine heterotrophs on refactored media reveals diverse metabolic adaptations and lifestyle strategies

Forchielli, E. J.; Sher, D. J.; Segre, D.

10.1101/2022.01.07.475430 — microbiology — Posted on 2022-01-09

3020 Resource allocation to cell envelopes and the scaling of bacterial growth rate

Trickovic, B.; Lynch, M.

10.1101/2022.01.07.475415 — systems biology — Posted on 2022-01-09

3021 SH3Ps recruit auxilin-like vesicle uncoating factors into clathrin-mediated endocytosis

Adamowski, M.; Matijevic, I.; Narasimhan, M.; Friml, J.

10.1101/2022.01.07.475403 — plant biology — Posted on 2022-01-09

3022 Developmental patterning function of GNOM ARF-GEF mediated from the plasma membrane

Adamowski, M.; Matijevic, I.; Friml, J.

10.1101/2022.01.07.475418 — plant biology — Posted on 2022-01-09

3023 Characterization of CAP1 and ECA4 adaptors participating in clathrin-mediated endocytosis

Adamowski, M.; Matijevic, I.; Friml, J.

10.1101/2022.01.07.475412 — plant biology — Posted on 2022-01-09

3024 Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Tumor

10.1101/2022.01.09.475410 — cancer biology — Posted on 2022-01-09

3025 Estimating Pan evolutionary history from nucleotide site patterns

Brand, C. M.; White, F. J.; Rogers, A. R.; Webster, T. H.

10.1101/2022.01.07.475438 — genomics — Posted on 2022-01-09

3026 Toxoflavin secreted by Pseudomonas alcaliphila inhibits growth of Legionella pneumophila and its host Vermamoeba vermiformis

Faucher, S. P.; Matthews, S.; Nickzad, A.; Vounba, P.; Shetty, D.; Bedard, E.; Prevost, M.; Deziel, E.; Paranjape, K.

10.1101/2022.01.08.475489 — microbiology — Posted on 2022-01-09

3027 Critical Pressure of Intramural Delamination in Aortic Dissection

Ban, E.; Cavinato, C.; Humphrey, J. D.

10.1101/2021.09.12.459981 — bioengineering — Posted on 2022-01-10

3028 Multi-omics profiling of Earth's biomes reveals that microbial and metabolite composition are shaped by the environment

Shaffer, J. P.; Nothias, L.-F.; Thompson, L. R.; Jon, S. G.; Salido, R. A.; Couvillion, S. P.; Brejnrod, A. D.; Huang, S.; Lejzerowicz, F.; Lutz, H. L.; Zhu, Q.; Martino, C.; Morton, J. T.; Karthikeyan, S.; Nothias-Esposito, M.; Dührkop, K.; Böcker, S.; Kim, H.; Aksenov, A. A.; Bittremieux, W.; Minich, J. J.; Marotz, C.; Bryant, M. M.; Sanders, K.; Schwartz, T.; Humphrey, G.; Vasquez-Baeza, Y.; Tripathi, A.; Parida, L.; Carrieri, A. P.; Haiminen, N.; Beck, K. L.; Das, P.; Gonzalez, A.; McDonald, D.; Karst, S. M.; Albertsen, M.; Ackermann, G.; DeReus, J.; Thomas, T.; Petras, D.; Shade, A.; St

10.1101/2021.06.04.446988 — ecology — Posted on 2022-01-10

3029 Aerobic methoxydotrophy: growth on methoxylated aromatic compounds by Methylobacterium

Lee, J. A.; Stolyar, S.; Marx, C. J.

10.1101/712836 — microbiology — Posted on 2022-01-10

3030 Heat-Dependent Hairpin Melting Drives TRPV1 Opening

Wang, G.

10.1101/2022.01.02.474701 — biophysics — Posted on 2022-01-10

3031 Intramolecular Communication and Allosteric Sites in Enzymes Unraveled by Time-Dependent Linear Response Theory

Huang, B.-C.; Cheng, Y.-Y.; Chang-Chein, C.-H.; Yao, C.-L.; Yang, L.-W.

10.1101/677617 — biophysics — Posted on 2022-01-10

3032 Entropy of city street networks linked to future spatial navigation ability

Coutrot, A.; Manley, E.; Goodroe, S.; Gahnstrom, C.; Filomena, G.; Yesiltepe, D.; Dalton, R. C.; Wiener, J. M.; Holscher, C.; Hornberger, M.; Spiers, H. J.

10.1101/2020.01.23.917211 — neuroscience — Posted on 2022-01-10

3033 Transcription shapes 3D chromatin organization by interacting with loop-extruding cohesin complexes

Banigan, E. J.; Tang, W.; van den Berg, A. A.; Stocsits, R. R.; Wutz, G.; Brandao, H. B.; Busslinger, G. A.; Peters, J.-M.; Mirny, L. A.

10.1101/2022.01.07.475367 — genomics — Posted on 2022-01-08

3034 Analysis of historical selection in winter wheat

Yang, C. J.; Ladejobi, O.; Mott, R.; Powell, W.; Mackay, I.

10.1101/2022.01.07.475391 — genetics — Posted on 2022-01-08

3035 The cell growth cycle: resource allocation and subcellular pattern formation in budding yeast.

Machne, R.; Murray, D. B.; Bernhart, S. H.; Axmann, I. M.; Stadler, P. F.

10.1101/2021.05.26.444658 — cell biology — Posted on 2022-01-10

3036 Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration

Meehan, G. R.; McInnes, I. B.; Brewer, J. M.; Garside, P.

10.1101/2022.01.07.475399 — immunology — Posted on 2022-01-08

3037 Defining the dynamics of naive CD4 and CD8 T cells across the mouse lifespan

Rane, S.; Hogan, T.; Lee, E.; Seddon, B.; Yates, A.

10.1101/2022.01.07.475400 — immunology — Posted on 2022-01-08

3038 A Proposal for Finite But Unbounded Human Lifetimes

Huang, F.; Maller, R.; Milholland, B.; Ning, X.

10.1101/2022.01.07.474862 — systems biology — Posted on 2022-01-08

3039 Exploration of Methanomethylophilus alvus pyrrolysyl-tRNA synthetase activity in yeast

Stieglitz, J. T.; Lahiri, P.; Stout, M. I.; Van Deventer, J. A.

10.1101/2022.01.07.475408 — synthetic biology — Posted on 2022-01-08

3040 The scaffolding protein Flot2 regulates cytoneme-based transport of Wnt3 in gastric cancer

Routledge, D.; Rogers, S.; Ashktorab, H.; Phesse, T.; Scholpp, S.

10.1101/2022.01.07.475396 — cancer biology — Posted on 2022-01-08

3041 Dissecting conformational rearrangements and allosteric modulation in metabotropic glutamate receptor activation

Lecat-Guillet, N.; Quast, R. B.; Liu, H.; Moller, T. C.; Rovira, X.; Soldevilla, S.; Lamarque, L.; Trinquet, E.; Liu, J.; Pin, J.-P.; Rondard, P.; Margeat, E.

10.1101/2022.01.07.474531 — biophysics — Posted on 2022-01-08

3042 Actin isovariant ACT7 controls root meristem development in Arabidopsis through modulating auxin and ethylene responses

Numata, T.; Sugita, K.; Rahman, A. A.; Rahman, A.

10.1101/2021.05.12.443766 — plant biology — Posted on 2022-01-10

3043 Characterizing the body morphology of the first metacarpal in the Homininae using 3D geometric morphometrics

Morley, J.; Bucchi, A.; Lorenzo, C.; Püschel, T. A.

10.1101/2020.04.30.070326 — paleontology — Posted on 2022-01-10

3044 Simplifying MS1 and MS2 spectra to achieve lower mass error, more dynamic range, and higher peptide identification confidence on the Bruker timsTOF Pro

Wilding-McBride, D.; Dagley, L. F.; Spall, S. K.; Infusini, G.; Webb, A. I.

10.1101/2021.10.18.464737 — bioinformatics — Posted on 2022-01-10

3045 Flow-cell based technology for massively parallelcharacterization of base-modified DNA aptamers

Wu, D.; Feagin, T.; Mage, P.; Rangel, A.; Wan, L.; Kong, D.; Li, A.; Coller, J.; Eisenstein, M.; Soh, H. T.

10.1101/2020.04.25.060004 — bioengineering — Posted on 2022-01-10

3046 Selfish migrants: How a meiotic driver is selected to increase dispersal

Runge, J.-N.; Kokko, H.; Lindholm, A. K.

10.1101/2021.02.01.429134 — evolutionary biology — Posted on 2022-01-10

3047 Idiosyncratic epistasis leads to global fitness-correlated trends

Bakerlee, C. W.; Nguyen Ba, A. N.; Shulgina, Y.; Rojas-Echenique, J. I.; Desai, M. M.

10.1101/2021.09.22.461382 — evolutionary biology — Posted on 2022-01-10

3048 Pathways of savannization in a mesic African savanna-forest mosaic following an extreme fire

Beckett, H.; Staver, C.; Charles-Dominique, T.; Bond, W.

10.1101/2021.05.27.445949 — ecology — Posted on 2022-01-10

3049 Dynamic Turnover of PI4P and PI(4,5)P2 under Hypoxia Controls Electrostatic Plasma Membrane Targeting

Lu, J.; Dong, W.; Hammond, G. R.; Hong, Y.

10.1101/2022.01.07.475384 — cell biology — Posted on 2022-01-10

3050 Concurrent fMRI demonstrates propagation of TMS effects across task-related networks

Deng, L.; Gamboa, O. L.; Dannhauer, M.; Jonnalagadda, A.; Hamdan, R.; Crowell, C.; Worth, T.; Peterchev, A. V.; Sommer, M. A.; Cabeza, R.; Appelbaum, L. G.; Davis, S. W.

10.1101/2022.01.06.475293 — neuroscience — Posted on 2022-01-10

3051 Localized nanoscale induction by single domain magnetic particles

Christiansen, M. G.; Mirkhani, N.; Hornslien, W.; Schuerle, S.

10.1101/2020.07.16.207126 — neuroscience — Posted on 2022-01-10

3052 Acoustic camera system for measuring ultrasound communication in mice

Matsumoto, J.; Kanno, K.; Kato, M.; Nishimaru, H.; Setogawa, T.; Chinzorig, C.; Shibata, T.; Nishijo, H.

10.1101/2021.12.12.468927 — neuroscience — Posted on 2022-01-10

3053 Neural event segmentation of continuous experience in human infants

Yates, T. S.; Skalaban, L. J.; Ellis, C. T.; Bracher, A. J.; Baldassano, C.; Turk-Browne, N. B.

10.1101/2021.06.16.448755 — neuroscience — Posted on 2022-01-10

3054 The cytosolic Arabidopsis thaliana cysteine desulfurase ABA3 delivers sulfur to the sulfurtransferase STR18

Selles, B.; Moseler, A.; Caubriere, D.; Sun, S.-K.; Ziesel, M.; Dhalleine, T.; Heriche, M.; Wirtz, M.; Rouhier, N.; Couturier, J.

10.1101/2020.03.25.008375 — plant biology — Posted on 2022-01-10

3055 Reliable in silico ranking of engineered therapeutic TCR binding affinities with MMPBSA and MMGBSA.

Van der Kamp, M. W.; Crean, R. M.; Cole, D. K.; Pudney, C. R.

10.1101/2021.06.21.449221 — biophysics — Posted on 2022-01-10

3056 Nucleoplasmic Lamin C Rapidly Accumulates at Sites of Nuclear Envelope Rupture with BAF and cGAS

Kono, Y.; Adam, S. A.; Reddy, K.; Zheng, Y.; Medalia, O.; Goldman, R. D.; Kimura, H.; Shimi, T.

10.1101/2022.01.05.475028 — cell biology — Posted on 2022-01-10

3057 Toxin-producing endosymbionts shield pathogenic fungus against micropredators

Richer, I.; Radosa, S.; Cseresnyes, Z.; Ferling, I.; Buettner, H.; Niehs, S. P.; Gerst, R.; Figge, M. T.; Hillmann, F.; Hertweck, C.

10.1101/2022.01.07.475374 — microbiology — Posted on 2022-01-09

3058 High seroprevalence of SARS-CoV-2 in white-tailed deer (Odocoileus virginianus) at one of three captive cervid facilities in Texas

Roundy, C. M.; Nunez, C. M.; Thomas, L. F.; Auckland, L. D.; Tang, W.; Richison, J. J.; Green, B. R.; Hilton, C. D.; Cherry, M. J.; Pauvolid-Correa, A.; Hamer, G. L.; Cook, W. E.; Hamer, S. A.

10.1101/2022.01.05.475172 — zoology — Posted on 2022-01-09

3059 WhyD tailors surface polymers to prevent bacteriolysis and direct cell elongation in Streptococcus pneumoniae

Flores-Kim, J.; Dobihal, G. S.; Bernhardt, T. G.; Rudner, D. Z.

10.1101/2022.01.07.475315 — microbiology — Posted on 2022-01-09

3060 Interspecies transfer of syntenic RAMOSA1 orthologs and promoter cis sequences impacts maize inflorescence architecture

Strable, J.; Unger-Wallace, E.; Aragon-Raygoza, A.; Briggs, S.; Vollbrecht, E.

10.1101/2022.01.07.475427 — plant biology — Posted on 2022-01-09

3061 Glucocorticoid receptor dysregulation underlies 5-HT2A receptor-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model

Saunders, J. M.; Muguruza, C.; Sierra, S.; Moreno, J. L.; Callado, L. F.; Meana, J. J.; Beardsley, P. M.; Gonzalez-Maeso, J.

10.1101/2022.01.07.475437 — neuroscience — Posted on 2022-01-09

3062 Dominance of coniferous and broadleaved trees drives bacterial associations with boreal feather mosses

Rodriguez-Rodriguez, J. C.; Bergeron, Y.; Kembel, S. W.; Fenton, N. J.

10.1101/2022.01.07.475413 — microbiology — Posted on 2022-01-09

3063 The transcriptomic signature of physiological trade-offs caused by larval overcrowding in Drosophila melanogaster

Morimoto, J.; Derous, D.; Wenzel, M.; Henry, Y.; Colinet, H.

10.1101/2022.01.07.475433 — ecology — Posted on 2022-01-09

3064 Structural and functional analysis of the human Cone-rod homeobox transcription factor

Clanor, P.-M.; Buchholz, C.; Hayes, J. E.; Friedman, M. A.; White, A. M.; Enke, R. A.; Berndsen, C. E.

10.1101/2022.01.09.475544 — biochemistry — Posted on 2022-01-09

3065 Wnt11 family dependent morphogenesis during frog gastrulation is marked by the cleavage furrow protein anillin

Van Itallie, E. S.; Field, C. M.; Mitchison, T. J.; Kirschner, M. W.

10.1101/2022.01.07.475368 — developmental biology — Posted on 2022-01-08

3066 Dynamic changes in mRNA nucleocytoplasmic localization in the nitrate response of Arabidopsis roots

Fonseca, A.; Moyano, T. C.; Rosa, S.; Gutierrez, R. A.

10.1101/2022.01.07.475360 — molecular biology — Posted on 2022-01-09

3067 Compartmentalized Cell Envelope Biosynthesis in Mycobacterium tuberculosis

Puffal, J.; Sparks, I. L.; Brenner, J. R.; Li, X.; Leszyk, J. D.; Hayashi, J.; Shaffer, S. A.; Morita, Y. S.

10.1101/2022.01.07.475471 — microbiology — Posted on 2022-01-08

3068 MTORC2 is a physiological hydrophobic motif kinase of S6 Kinase 1.

Majeed, S. T.; Majeed, R.; Zargar, M. A.; Andrabi, K. I.

10.1101/2021.08.17.456612 — molecular biology — Posted on 2022-01-09

3069 Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among bloodstream isolates at a United States academic medical center

Kochan, T.; Nozick, S. H.; Medernach, R. L.; Cheung, B. H.; Gatesy, S. W.; Lebrun-Corbin, M.; Mitra, S. D.; Khalatyan, N.; Krapp, F.; Qi, C.; Ozer, E. A.; Hauser, A. R.

10.1101/2020.12.04.410209 — microbiology — Posted on 2022-01-09

3070 Application of a convolutional neural network to the quality control of MRI defacing

Delbarre, D. J.; Santos, L.; Ganjgahi, H.; Horner, N.; McCoy, A.; Westerberg, H.; Häring, D. A.; Nichols, T. E.; Mallon, A.-M.

10.1101/2021.06.24.449613 — neuroscience — Posted on 2022-01-09

3071 Robotic Search for Optimal Cell Culture in Regenerative Medicine

Kanda, G. N.; Tsuzuki, T.; Terada, M.; Sakai, N.; Motozawa, N.; Masuda, T.; Nishida, M.; Watanabe, C. T.; Higashi, T.; Horiguchi, S. A.; Kudo, T.; Kamei, M.; Sunagawa, G. A.; Matsukuma, K.; Sakurada, T.; Ozawa, Y.; Takahashi, M.; Takahashi, K.; Natsume, T.

10.1101/2020.11.25.392936 — systems biology — Posted on 2022-01-09

3072 Effects of various carbohydrates on the in vitro pollen germination of Vinca rosea and Cucumis melo var. utilissimus

Manchanda, P.; Sharma, S.; Marni, A. D.; Sharma, V.

10.1101/2020.10.03.316216 — plant biology — Posted on 2022-01-09

3073 A novel metric reveals previously unrecognized distortion in dimensionality reduction of scRNA-Seq data

Cooley, S. M.; Hamilton, T.; Ray, J. C. J.; Deeds, E. J.

10.1101/689851 — bioinformatics — Posted on 2022-01-09

3074 Raman Signal Denoising using Fully Convolutional Encoder Decoder Network

Loc, I.; Kecoglu, I.; Unlu, M. B.; Parlatan, U.

10.1101/2022.01.07.475347 — biochemistry — Posted on 2022-01-09

3075 Strict adherence to Mendel's First Law across a large sample of human sperm genomes

Carioscia, S. A.; Weaver, K. J.; Bortvin, A. N.; Ariad, D.; Bell, A. D.; McCoy, R. C.

10.1101/2021.11.19.469261 — genomics — Posted on 2022-01-09

3076 Horizontal transposon transfer and its implications for the ancestral ecology of hydrophiine snakes

Galbraith, J. D.; Ludington, A. J.; Sanders, K. L.; Amos, T. G.; Thomson, V. A.; Tuipulotu, D. E.; Dunstan, N.; Edwards, R. J.; Suh, A.; Adelson, D. L.

10.1101/2021.06.22.449521 — evolutionary biology — Posted on 2022-01-09

3077 Multifunctional role of GPCR signaling in epithelial tube formation

Vishwakarma, V.; Le, T. P.; Chung, S.

10.1101/2022.01.06.475238 — developmental biology — Posted on 2022-01-09

3078 DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics

Robertson, G. L.; Riffle, S. N.; Patel, M.; Marshall, A.; Beasley, H.; Garza-Lopez, E.; Shao, J.; Vue, Z.; Hinton, A.; Mears, J. A.; Gama, V.

10.1101/2021.12.31.474637 — cell biology — Posted on 2022-01-09

3079 Clp protease and antisense RNA jointly regulate the global regulator CarD to mediate mycobacterial starvation response

Li, X.; Chen, F.; Liu, X.; Xiao, J.; Andongma, B. T.; Tang, Q.; Cao, X.; Chou, S.-H.; Galperin, M. Y.; He, J.

10.1101/2021.04.15.439805 — microbiology — Posted on 2022-01-09

3080 Probing Causality of the Brainstem-Hypothalamic Murine Models of Sleep-Wake Regulation

Bahari, F.; Billard, M. W.; Kimbugwe, J.; Curay, C.; Watson, G. D. R.; Alloway, K. D.; Gluckman, B. J.

10.1101/2020.09.21.306456 — neuroscience — Posted on 2022-01-09

3081 Hue tuning curves in V4 change with visual context

Benjamin, A. S.; Ramkumar, P.; Fernandes, H.; Smith, M. A.; Kording, K. P.

10.1101/780478 — neuroscience — Posted on 2022-01-09

3082 FPCountR: Absolute quantification of fluorescent proteins for synthetic biology

Csibra, E.; Stan, G.-B.

10.1101/2021.12.06.471413 — synthetic biology — Posted on 2022-01-09

3083 Behavioral and postural analyses establish sleep-like states for mosquitoes that can impact interactions with hosts

Ajayi, O. M.; Marlman, J. M.; Gleitz, L. A.; Smith, E. S.; Piller, B. D.; Krupa, J. A.; Vinauger, C.; Benoit, J. B.

10.1101/2021.11.11.467918 — physiology — Posted on 2022-01-09

3084 Inferring parameters of cancer evolution from sequencing and clinical data

Lee, N. D.; Bozic, I.

10.1101/2020.11.18.387837 — cancer biology — Posted on 2022-01-09

3085 Targeting EGFR in glioblastoma with a novel brain-penetrant small molecule EGFR-TKI

Ni, J.; Wang, Y.; Wang, Q.; Bergholz, J. S.; Jiang, T.; Roberts, T. M.; Gray, N. S.; Zhao, J. J.

10.1101/2021.01.09.426030 — cancer biology — Posted on 2022-01-09

3086 A multi-state dynamic process confers mechano-adaptation to the bacterial flagellar motor

Wadhwa, N.; Sassi, A. S.; Berg, H. C.; Tu, Y.

10.1101/2021.12.22.473861 — biophysics — Posted on 2022-01-09

3087 A native chemical chaperone in the human eye lens

Serebryany, E.; Chowdhury, S.; Woods, C. N.; Thorn, D. C.; Watson, N. E.; McClelland, A.; Klevit, R. E.; Shakhnovich, E. I.

10.1101/2020.12.16.423154 — biophysics — Posted on 2022-01-09

3088 Heterogeneous interactions and polymer entropy decide organization and dynamics of chromatin domains

Kumari, K.; Ravi Prakash, J.; Padinhateeri, R.

10.1101/2021.02.17.431616 — biophysics — Posted on 2022-01-09

3089 Signalling centre vortices coordinate collective behaviour in social amoebae

Ford, H. Z.; Manhart, A.; Chubb, J. R.

10.1101/2022.01.07.475371 — biophysics — Posted on 2022-01-09

3090 dsSurvival: Privacy preserving survival models for federated individual patient meta-analysis in DataSHIELD

Banerjee, S.; Sofack, G.; Papakonstantinou, T.; Avraam, D.; Burton, P.; Zöller, D.; Bishop, T. R.

10.1101/2022.01.04.471418 — bioinformatics — Posted on 2022-01-09

3091 A learned embedding for efficient joint analysis of millions of mass spectra

Bittremieux, W.; May, D. H.; Bilmes, J.; Noble, W. S.

10.1101/483263 — bioinformatics — Posted on 2022-01-09

3092 Identification of Differentially Expressed Genes and associated pathways common to Eyelid and Non-Ocular Basal Cell Carcinoma to understand the Molecular Biology of BCC

Vats, P.; Jayaraj, P.; Sen, S.; Dahiya, S.; Mohindroo, V.

10.1101/2021.05.01.442022 — bioinformatics — Posted on 2022-01-09

Krivonosov, M.; Nazarenko, T.; Bacalini, M. G.; Vedunova, M.; Franceschi, C.; Zaikin, A.; Ivanchenko, M.

10.1101/2020.03.10.986505 — bioinformatics — Posted on 2022-01-09

3094 Micro topographical instruction of bacterial attachment, biofilm formation and in vivo host response

10.1101/2020.10.10.328146 — bioengineering — Posted on 2022-01-09

3095 High nucleotide substitution rates associated with retrotransposon proliferation drive dynamic secretome evolution in smut pathogens

Depotter, J. R.; Oekmen, B.; Ebert, M. K.; Beckers, J.; Kruse, J.; Thines, M.; Doehlemann, G.

10.1101/2021.04.23.441129 — evolutionary biology — Posted on 2022-01-09

3096 Evolution of genes involved in the unusual genitals of the bear macaque, Macaca arctoides

Stevison, L.; Bailey, N. P.; Szpiech, Z. A.; Novak, T. E.; Melnick, D. J.; Evans, B. J.; Wall, J. D.

10.1101/2020.05.18.102251 — evolutionary biology — Posted on 2022-01-09

3097 Extracting abundance information from DNA-based data

Luo, M.; Ji, Y.; Yu, D. W.

10.1101/2022.01.06.475221 — ecology — Posted on 2022-01-09

3098 Contribution of cytoplasm viscoelastic properties to mitotic spindle positioning

Xie, J.; Najafi, J.; Le Borgne, R.; Durieu, C.; Verbavatz, J.-M.; Salle, J.; Minc, N.

10.1101/2021.10.21.465315 — cell biology — Posted on 2022-01-09

3099 HIV-induced membraneless organelles orchestrate post-nuclear entry steps.

Scoca, V.; Morin, R.; Tinevez, J.-Y.; Di Nunzio, F.

10.1101/2020.11.17.385567 — microbiology — Posted on 2022-01-09

3100 Stress-sensitive inference of task controllability

Ligneul, R.; Mainen, Z.; Ly, V.; Cools, R.

10.1101/2020.11.19.390393 — neuroscience — Posted on 2022-01-09

3101 Consistent population activity on the scale of minutes in the mouse hippocampus

Liu, Y.; Levy, S. J.; Mau, W.; Geva, N.; Rubin, A.; Ziv, Y.; Hasselmo, M.; Howard, M.

10.1101/2021.02.07.430172 — neuroscience — Posted on 2022-01-09

3102 The voltage and spiking responses of subthreshold resonant neurons to structured and fluctuating inputs: persistence and loss of resonance and variability

Pena, R. F.; Rotstein, H. G.

10.1101/2021.06.14.448368 — neuroscience — Posted on 2022-01-09

3103 Outer hair cell electro-mechanical power conversion

Rabbitt, R. D.

10.1101/2021.07.29.454372 — physiology — Posted on 2022-01-09

3104 The Relationship Between Soldier Height, Weight and Army Combat Fitness Scores

Palmer, R.; DeBeliso, M.

10.1101/2021.12.22.473875 — physiology — Posted on 2022-01-09

3105 Signalling centre vortices coordinate collective behaviour in social amoebae

Ford, H. Z.; Manhart, A.; Chubb, J. R.

10.1101/2022.01.07.475371 — biophysics — Posted on 2022-01-08

3106 Separable roles for RNAi in regulation of transposable elements and viability in the fission yeast Schizosaccharomyces japonicus

Chapman, E.; Taglini, F.; Bayne, E. H.

10.1101/2022.01.07.475324 — molecular biology — Posted on 2022-01-08

3107 Regulation of Chromatin Accessibility by hypoxia and HIF

Batie, M.; Frost, J.; Shakir, D.; Rocha, S.

10.1101/2022.01.07.475388 — molecular biology — Posted on 2022-01-08

3108 Digenic traits under population admixture and inbreeding

Smith, R. D.

10.1101/2022.01.07.475385 — genetics — Posted on 2022-01-08

3109 Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR

Perez Verdaguer, M.; Zhang, T.; Paulo, J. A.; Wallace, C.; Watkins, S. C.; Gygi, S. P.; Sorkin, A.

10.1101/2022.01.07.475389 — systems biology — Posted on 2022-01-08

3110 Ecological speciation promoted by divergent regulation of functional genes within African cichlid fishes

Carruthers, M.; Edgley, D. E.; Saxon, A. D.; Gabagambi, N. P.; Shechonge, A.; Miska, E. A.; Durbin, R.; Bridle, J. R.; Turner, G. F.; Genner, M. J.

10.1101/2022.01.07.475335 — evolutionary biology — Posted on 2022-01-08

3111 A novel mouse model based on intersectional genetics enables unambiguous in vivo discrimination between plasmacytoid and other dendritic cells and their comparative characterization

Valente, M.; Collinet, N.; Vu Manh, T.-P.; Naciri, K.; Bessou, G.; Gil, L.; Milpied, P.; Tomasello, E.; Dalod, M.

10.1101/2022.01.07.475382 — immunology — Posted on 2022-01-08

3112 Comprehensive analysis of disease pathology in immunocompetent and immunocompromised hamster models of SARS-CoV-2 infection

Ramasamy, S.; Kolloli, A.; Kumar, R.; Hussain, S.; Soteropoulos, P.; Chang, T.; Subbian, S.

10.1101/2022.01.07.475406 — pathology — Posted on 2022-01-08

3113 Time-adaptive Unsupervised Auditory Attention Decoding Using EEG-based Stimulus Reconstruction

Geirnaert, S.; Francart, T.; Bertrand, A.

10.1101/2022.01.07.475386 — neuroscience — Posted on 2022-01-08

3114 Frequency Effects on Spelling Error Recognition: An ERP Study

Larionova, E.; Martynova, O.

10.1101/2022.01.07.475328 — neuroscience — Posted on 2022-01-08

3115 Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome

Yatskevich, S.; Muir, K. W.; Bellini, D.; Zhang, Z.; Yang, J.; Tischer, T.; Predin, M.; Dendooven, T.; McLaughlin, S. H.; Barford, D.

10.1101/2022.01.07.475394 — biochemistry — Posted on 2022-01-08

3116 Homologous recombination between tandem paralogues drives evolution of Type VII secretion system immunity genes in firmicute bacteria

Garrett, S.; Mariano, G.; Palmer, T.

10.1101/2022.01.07.475358 — microbiology — Posted on 2022-01-08

3117 Climate Surveys of Biomedical PhD Students and Training Faculty Members in the Time of Covid

Ramadoss, D.; McCord, M. C.; Horn, J. P.

10.1101/2022.01.06.475246 — scientific communication and education — Posted on 2022-01-07

3118 Improving AlphaFold modeling using implicit information from experimental density maps

Terwilliger, T. C.; Poon, B. K.; Afonine, P.; Schlicksup, C. J.; Croll, T. I.; Millan-Nebot, C.; Richardson, J. S.; Read, R. J.; Adams, P. D.

10.1101/2022.01.07.475350 — biochemistry — Posted on 2022-01-07

3119 Delayed processing of blood samples impairs the accuracy of mRNA-based biomarkers

Wilson, C.; Dias, N.; Pancini, S.; Mercadante, V.; Biase, F.

10.1101/2022.01.07.475362 — genomics — Posted on 2022-01-07

3120 Covariant Fitness Clusters Reveal Structural Evolution of SARS-CoV-2 Polymerase Across the Human Population

Wang, C.; Elghobashi-Meinhardt, N.; Balch, W. E.

10.1101/2022.01.07.475295 — evolutionary biology — Posted on 2022-01-07

3121 Spread of new mutations through space

Shaw, K.; Beerli, P.

10.1101/2022.01.07.475395 — evolutionary biology — Posted on 2022-01-07

3122 On the environmental zero-point problem in microevolutionary climate response predictions

Ergon, R.

10.1101/2022.01.07.475361 — evolutionary biology — Posted on 2022-01-07

3123 Integrated Tick Management in the Upper Midwest: Impact of Invasive Vegetation Removal and Host-targeted Acaricides on Ixodes scapularis Infestation and Borrelia burgdorferi Prevalence of Small Mammals

Mandli, J. T.; Lee, X.; Paskewitz, S. M.

10.1101/2022.01.07.475376 — ecology — Posted on 2022-01-07

3124 The native - exotic plant choice in green roof design: using a multicriteria decision framework to foster urban biodiversity

Calvino, A. A.; Tavella, J.; Beccacece, H. M.; Estallo, E.; Fabian, D.; Moreno, M. L.; Salvo, A.; Fenoglio, M. S.

10.1101/2022.01.07.475351 — ecology — Posted on 2022-01-07

3125 Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation

Camuglia, J. M.; Chanet, S.; Martin, A. C.

10.1101/2022.01.07.475359 — cell biology — Posted on 2022-01-07

3126 The salivary, metal-binding peptide histatin-5 buffers extracellular copper availability

Stewart, L.; Hong, Y.; Holmes, I.; Firth, S.; Bolton, J.; Santos, Y.; Cobb, S.; Jakubovics, N.; Djoko, K.

10.1101/2022.01.07.472205 — microbiology — Posted on 2022-01-07

3127 Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

Nelson, C. E.; Namasivayam, S.; Foreman, T. W.; Kauffman, K. D.; Sakai, S.; Dorosky, D. E.; Lora, N. E.; NIAID/DIR Tuberculosis Imaging Program, ; Brooks, K.; Potter, E. L.; Roederer, M.; Sher, A.; Weiskopf, D.; Sette, A.; de Wit, E.; Hickman, H. D.; Brenchley, J. M.; Via, L. E.; Barber, D. L.

10.1101/2022.01.06.475282 — immunology — Posted on 2022-01-07

3128 Relapse-like behavior and nAChR sensitization following intermittent access nicotine self-administration

Drenan, R.; Jin, X.-T.; Tucker, B.; Thomas, L.; Walker, N.; Kim, V.; Albertson, S.; Damuka, N.; Krizan, I.; Edassery, S.; Savas, J.; Sai, K. K. S.; Jones, S.; Tapia, M.

10.1101/2022.01.07.475355 — neuroscience — Posted on 2022-01-07

3129 Multi-micron crisscross structures from combinatorially assembled DNA-origami slats

Wintersinger, C. M.; Minev, D.; Ershova, A.; Sasaki, H.; Gowri, G.; Berengut, J.; Corea-Dilbert, F. E.; Yin, P.; Shih, W.

10.1101/2022.01.06.475243 — synthetic biology — Posted on 2022-01-07

3130 basicsynbio and the BASIC SEVA collection: Software and vectors for an established DNA assembly method

Haines, M. C.; Carling, B.; Marshall, J.; Storch, M.; Freemont, P. C.

10.1101/2022.01.06.446575 — synthetic biology — Posted on 2022-01-07

3131 Phylogenomics reveals the evolutionary origin of lichenization in chlorophyte algae

Keller, J.; Puginier, C.; Libourel, C.; Otte, J.; Skaloud, P.; Delaux, P.-M.; Dal Grande, F.

10.1101/2022.01.06.475074 — plant biology — Posted on 2022-01-07

3132 Integrating Cell Morphology with Gene Expression and Chemical Structure to Aid Mitochondrial Toxicity Detection

Seal, S.; Carreras-Puigvert, J.; Trapotsi, M.-A.; Yang, H.; Spjuth, O.; Bender, A.

10.1101/2022.01.07.475326 — bioinformatics — Posted on 2022-01-07

3133 Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes

Pradier, L.; Bedhomme, S.

10.1101/2022.01.07.475340 — genomics — Posted on 2022-01-07

3134 Globally invariant metabolism but density-diversity mismatch in springtails

Potapov, A. M.; Guerra, C. A.; van den Hoogen, J.; Babenko, A.; Bellini, B. C.; Berg, M. P.; Chown, S. L.; Deharveng, L.; Kova_, L.; Kuznetsova, N. A.; Ponge, J.-F.; Potapov, M. B.; Russell, D. J.; Alexandre, D.; Alatalo, J. M.; Arbea, J. I.; Bandyopadhyay, I.; Bernava, V.; Bokhorst, S.; Bolger, T.; Castano-Meneses, G.; Chauvat, M.; Chen, T.-W.; Chomel, M.; Classen, A. T.; Cortet, J.; Cuchta, P.; de la Pedrosa, A. M.; Ferreira, S. S. D.; Fiera, C.; Filser, J.; Franken, O.; Fujii, S.; Gagnon koudji, E.; Gao, M.; Gendreau-Berthiaume, B.; Gomez-Pamies, D. F.; Greve, M.; Handa, I. T.; Heiniger, C.

10.1101/2022.01.07.475345 — ecology — Posted on 2022-01-07

3135 Sustained upregulation of widespread hippocampal-neocortical coupling following memory encoding

Folvik, L.; Sneve, M. H.; Ness, H.; Vidal-Pineiro, D.; Raud, L.; Geier, O. M.; Walhovd, K. B.; Fjell, A. M.

10.1101/2022.01.07.475348 — neuroscience — Posted on 2022-01-07

3136 Hexosamine pathway activation improves memory but does not extend lifespan in mice.

Allmeroth, K.; Hartman, M. D.; Purrio, M.; Mesaros, A.; Denzel, M. S.

10.1101/2022.01.07.475325 — physiology — Posted on 2022-01-07

3137 Features of smaller ribosomes in Candidate Phyla Radiation (CPR) bacteria revealed with a molecular evolutionary analysis

Tsurumaki, M.; Saito, M.; Tomita, M.; Kanai, A.

10.1101/2022.01.07.475337 — bioinformatics — Posted on 2022-01-07

3138 Raman Signal Denoising Using Fully Convolutional Encoder Decoder Network

Loc, I.; Kecoglu, I.; Unlu, M. B.; Parlatan, U.

10.1101/2022.01.07.475347 — biochemistry — Posted on 2022-01-07

3139 Busy and confused? High risk of missed alerts in the cockpit: an electrophysiological study

Causse, M.; Parmentier, F.; Mouratille, D.; Thibaut, D.; Kisselenko, M.; Fabre, E. F.

10.1101/2022.01.07.475323 — neuroscience — Posted on 2022-01-07

3140 Wnt/PCP signaling mediates breast cancer metastasis by promoting pro-invasive protrusion formation in collectively motile leader cells

VanderVorst, K.; Dreyer, C.; Hatakeyama, J.; Bell, G. R.; Berg, A. L.; Hernandez, M.; Lee, H.; Collins, S. R.; Carraway, K. L.

10.1101/2022.01.07.475316 — cancer biology — Posted on 2022-01-07

3141 Autoantibody and hormone activation of the thyrotropin G protein-coupled receptor

Faust, B.; Singh, I.; Zhang, K.; Hoppe, N.; Pinto, A. F. M.; Muftuoglu, Y.; Billesboelle, C. B.; Saghatelian, A.; Cheng, Y.; Manglik, A.

10.1101/2022.01.06.475289 — biochemistry — Posted on 2022-01-07

3142 Common neural functions during children's naturalistic and controlled laboratory mathematics learning

Amalric, M.; Cantlon, J.

10.1101/2022.01.07.475365 — neuroscience — Posted on 2022-01-07

3143 CHDbase: A Comprehensive Knowledgebase for Congenital Heart Disease-related Genes and Clinical Manifestations

Zhou, W.-Z.; Li, W.; Shen, H.; Wang, R. W.; Chen, W.; Zhang, Y.; Zeng, Q.; Wang, H.; Yuan, M.; Zeng, Z.; Cui, J.; Li, C.-Y.; Ye, F. Y.; Zhou, Z.

10.1101/2022.01.06.475217 — genetics — Posted on 2022-01-07

3144 Comparing transmission reconstruction models with Mycobacterium tuberculosis whole genome sequence data

Sobkowiak, B.; Romanowski, K.; Sekirov, I.; Gardy, J. L.; Johnston, J.

10.1101/2022.01.07.475333 — bioinformatics — Posted on 2022-01-07

3145 Assessing and assuring interoperability of a genomics file format

Niu, Y. N.; Roberts, E. G.; Denisko, D.; Hoffman, M. M.

10.1101/2022.01.07.475366 — bioinformatics — Posted on 2022-01-07

3146 GraphChainer: Co-linear Chaining for Accurate Alignment of Long Reads to Variation Graphs

Ma, J.; Caceres, M.; Salmela, L.; Mäkinen, V.; Tomescu, A. I.

10.1101/2022.01.07.475257 — bioinformatics — Posted on 2022-01-07

3147 Extracting abundance information from DNA-based data

Luo, M.; Ji, Y.; Yu, D. W.

10.1101/2022.01.06.475221 — ecology — Posted on 2022-01-07

3148 Characterization of ultrapotent chemogenetic ligands for research applications in non-human primates

Raper, J.; Eldridge, M. A. G.; Sternson, S.; Shim, J. Y.; Fomani, G. P.; Richmond, B. J.; Wichmann, T.; Galvan, A.

10.1101/2022.01.06.475241 — neuroscience — Posted on 2022-01-07

3149 Loss-of-function of OTUD7A in the schizophrenia-associated 15q13.3 deletion impairs synapse development and function in human neurons

Kozlova, A.; Zhang, S.; Kotlar, A. V.; Jamison, B.; Zhang, H.; Shi, S.; Forrest, M. P.; McDaid, J.; Cutler, D. J.; Epstein, M. P.; Zwick, M. E.; Pang, Z. P.; Sanders, A. R.; Warren, S. T.; Gejman, P. V.; Mulle, J. G.; Duan, J.

10.1101/2022.01.06.473910 — neuroscience — Posted on 2022-01-07

3150 Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood.

Dannenhoffer, C. A.; Gomez-A, A.; Macht, V.; Jawad, R.; Sutherland, E. B.; Vetreno, R. P.; Crews, F. T.; Boettiger, C.; Robinson, D.

10.1101/2022.01.07.475220 — neuroscience — Posted on 2022-01-07

3151 Differences in pathways contributing to thyroid hormone effects on postnatal cartilage calcification versus secondary ossification center development

Mohan, S.; Gomez, G. A.; Aghajanian, P.; Pourteymoor, S.; Larkin, D.

10.1101/2022.01.07.475320 — physiology — Posted on 2022-01-07

3152 Resolving Protein Conformational Plasticity and Substrate Binding Through the Lens of Machine-Learning

Ahalawat, N.; Mondal, J.

10.1101/2022.01.07.475334 — biophysics — Posted on 2022-01-07

3153 Fluid-structure interaction analysis of eccentricity and leaflet rigidity on thrombosis biomarkers in bioprosthetic aortic valve replacements

Oks, D.; Vazquez, M.; Houzeaux, G.; Butakoff, C.; Samaniego, C.

10.1101/2022.01.06.475272 — bioengineering — Posted on 2022-01-07

3154 Translational buffering by ribosome stalling in upstream open reading frames

Bottorff, T. A.; Geballe, A. P.; Subramaniam, A. R.

10.1101/2022.01.06.475296 — molecular biology — Posted on 2022-01-07

3155 Thermal characterization of the multimeric bacteriophage endolysin PlyC

Hoopes, J. T.; Heselpoth, R. D.; Schwarz, F. P.; Nelson, D. C.

10.1101/2022.01.06.475266 — biophysics — Posted on 2022-01-07

3156 Homologous BHLH transcription factors induce distinct deformations of torsionally-stressed DNA: a potential transcription regulation mechanism.

Hörberg, J.; Moreau, K.; Reymer, A.

10.1101/2022.01.07.475332 — biochemistry — Posted on 2022-01-07

Vitrinel, B.; Vogel, C.; Christiaen, L.

10.1101/2022.01.07.475354 — developmental biology — Posted on 2022-01-07

3158 Non-alcoholic components of Pelinkovac, a Croatian wormwood-based strong liquor, counteract the inhibitory effect of high ethanol concentration on catalase in vitro

Homolak, J.; Babic Perhoc, A.; Joja, M.; Kodvanj, I.; Toljan, K.; Virag, D.

10.1101/2022.01.07.475357 — pharmacology and toxicology — Posted on 2022-01-07

3159 Revised Michaelis-Menten rate law with time-varying molecular concentrations

Lim, R.; Martin, T. L. P.; Chae, J.; Kim, W.; Kim, H.; Ghim, C.-M.; Kim, P.-J.

10.1101/2022.01.07.475310 — biophysics — Posted on 2022-01-07

3160 Heparin-derived theranostic nanoprobes overcome the blood-brain barrier and target glioma in murine model

Samanta, S.; Le Joncour, V.; Wegrzyniak, O.; Rangasami, V.; Ali-Loytty, H.; Hong, T.; Selvaraju, R. K.; Aberg, O.; Hilborn, J.; Laakkonen, P.; Varghese, O. P.; Eriksson, O.; Cabral, H.; Oommen, O. P.

10.1101/2022.01.07.475195 — bioengineering — Posted on 2022-01-07

3161 Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

Zhao, F.; Keating, C.; Ozorowski, G.; Shaabani, N.; Francino-Urdaniz, I. M.; Barman, S.; Limbo, O.; Burns, A.; Zhou, P.; Ricciardi, M.; Woehl, J.; Tran, Q.; Turner, H. L.; Peng, L.; Huang, D.; Nemazee, D.; Andrabi, R.; Sok, D.; Teijaro, J. R.; Whitehead, T. A.; Ward, A. B.; Burton, D.; Jardine, J. G.

10.1101/2022.01.06.475303 — bioengineering — Posted on 2022-01-07

3162 In vitro and in vivo venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by Dispholidus typus

Menzies, S. K.; Clare, R. H.; Xie, C.; Westhorpe, A.; Hall, S. R.; Edge, R. J.; Alsolaiss, J.; Crittenden, E.; Harrison, R. A.; Kool, J.; Casewell, N. R.

10.1101/2022.01.07.475313 — pharmacology and toxicology — Posted on 2022-01-07

3163 A kinase translocation reporter reveals real-time dynamics of ERK activity in Drosophila

Yuen, A. C.; Prasad, A. R.; Fernandes, V. M.; Amoyel, M.

10.1101/2022.01.07.475336 — developmental biology — Posted on 2022-01-07

3164 Multi-omics reveals principles of gene regulation and pervasive non-productive transcription in the human cytomegalovirus genome

Jürges, C. S.; Lodha, M.; Le-Trilling, V. T. K.; Bhandare, P.; Wolf, E.; Zimmermann, A.; Trilling, M.; Prusty, B.; Dölken, L.; Erhard, F.

10.1101/2022.01.07.472583 — microbiology — Posted on 2022-01-07

3165 Molecular convergence by differential domain acquisition is a hallmark of chromosomal passenger complex evolution

Komaki, S.; Tromer, E. C.; De Jaeger, G.; De Winne, N.; Heese, M.; Schnittger, A.

10.1101/2022.01.07.475321 — cell biology — Posted on 2022-01-07

3166 Sulfane sulfur post-translationally modifies the global regulator AdpA to influence actinorhodin production and morphological differentiation of Streptomyces coelicolor

Liu, H.; Xun, L.; Lu, T.; Wu, X.; Cao, Q.; Xia, Y.

10.1101/2022.01.06.475307 — microbiology — Posted on 2022-01-07

3167 Molecular Insights into the Differential Dynamics of SARS-CoV-2 Variants of Concern (VOCs)

Mandal, N.; Padhi, A. K.; Rath, S. L.

10.1101/2021.10.22.465272 — biophysics — Posted on 2022-01-07

3168 The diversity and functional capacity of microbes associated with coastal phototrophs

Miranda, K. K.; Weigel, B. L.; Fogarty, E.; Veseli, I. A.; Giblin, A.; Murat Eren, A.; Pfister, C. A.

10.1101/2022.01.05.475171 — ecology — Posted on 2022-01-07

3169 Separate to operate: the centriole-free inner core of the centrosome regulates the assembly of the intranuclear spindle in Toxoplasma gondii

Tomasina, R.; Martins-Duarte, E. S.; Bastin, P.; Gissot, M.; Francia, M. E.

10.1101/2022.01.05.475174 — cell biology — Posted on 2022-01-07

3170 Barley stripe mosaic virus γb protein targets thioredoxin h-type 1 to dampen SA-mediated antiviral defenses

Jiang, Z.; Jin, X.; Yang, M.; Pi, Q.; Cao, Q.; Li, Z.; Zhang, Y.; Wang, X.-B.; Han, C.-G.; Yu, J.-L.; Li, D.

10.1101/2022.01.06.475245 — microbiology — Posted on 2022-01-07

3171 Analysis of SARS-CoV-2 Omicron Neutralization Data up to 2021-12-22

Netzl, A.; Tureli, S.; LeGresley, E.; Mühlemann, B.; Wilks, S. H.; Smith, D. J.

10.1101/2021.12.31.474032 — immunology — Posted on 2022-01-07

3172 Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses

Dosil, S. G.; Lopez-Cobo, S.; Rodriguez-Galan, A.; Fernandez-Delgado, I.; Ramirez-Huesca, M.; Milan-Rois, P.; Castellanos, M.; Somoza, A.; Gomez, M. J.; Reyburn, H. T.; Vales-Gomez, M.; Sanchez Madrid, F.; Fernandez-Messina, L.

10.1101/2022.01.05.475119 — immunology — Posted on 2022-01-07

3173 New insights on the role of HCN in root hair elongation through single cell proteomics

Garcia, I.; Arenas-Alfonseca, L.; Romero, L. C.; Yamada, M.

10.1101/2022.01.05.475094 — plant biology — Posted on 2022-01-07

3174 Duckweed roots are dispensable and are on a trajectory toward vestigiality

Bishopp, A.; Ware, A.; Jones, D. H.; Flis, P.; Smith, K. E.; Kümpers, B.; Yant, L.; Atkinson, J.; Wells, D. M.

10.1101/2022.01.05.475062 — evolutionary biology — Posted on 2022-01-07

3175 Orthohantavirus infection in two rodent species that inhabit wetlands in the central-east region of Argentina

Maroli, M.; Bellomo, C. M.; Coelho, R. M.; Martinez, V. P.; Pina, C. I.; Gomez Villafane, I.

10.1101/2022.01.05.475175 — ecology — Posted on 2022-01-07

3176 Functional oscillation of a multienzyme glucosome assembly during cell cycle progression

Jeon, M.; Schmitt, D. L.; Kyoung, M.; An, S.

10.1101/2022.01.06.475270 — cell biology — Posted on 2022-01-07

3177 LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

Westendorf, K.; Wang, L.; Zentelis, S.; Foster, D.; Vaillancourt, P.; Wiggin, M.; Lovett, E.; van der Lee, R.; Hendle, J.; Pustilnik, A.; Sauder, J. M.; Kraft, L.; Hwang, Y.; Siegel, R. W.; Chen, J.; Heinz, B. A.; Higgs, R. E.; Kallewaard, N.; Jepson, K.; Goya, R.; Smith, M. A.; Collins, D. W.; Pellacani, D.; Xiang, P.; de Puyraimond, V.; Ricicova, M.; Devorkin, L.; Pritchard, C.; O'Neill, A.; Dalal, K.; Panwar, P.; Dhupar, H.; Garces, F. A.; Cohen, C.; Dye, J.; Huie, K. E.; Badger, C. V.; Kobasa, D.; Audet, J.; Freitas, J. J.; Hassanali, S.; Hughes, I.; Munoz, L.; Palma, H. C.; Ramamurthy, B.

10.1101/2021.04.30.442182 — immunology — Posted on 2022-01-07

3178 Reduced mesophyll conductance by cell wall thickening and chloroplasts decreasing driven the decline of photosynthesis under sole NH4+ supply

cao, y.; Pan, Y.; Liu, T.; Wang, M.; Guo, S.

10.1101/2022.01.05.475041 — physiology — Posted on 2022-01-07

3179 Truncation of IFT80 causes early embryonic loss in cattle

Obando Ortega, M. S.; Bickhart, D. M.; Clark, K. N.; Null, D. J.; Hutchison, J. L.; McClure, J. C.; Cole, J. B.

10.1101/2021.07.02.450952 — genomics — Posted on 2022-01-07

3180 Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization

Demeter, M. C.; Derenyi, I.; Szöllosi, G. J.

10.1101/2020.07.16.206862 — evolutionary biology — Posted on 2022-01-07

3181 Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

Takeda, T.; Yamano, S.; Goto, Y.; Hirai, S.; Furukawa, Y.; Kikuchi, Y.; Misumi, K.; Suzuki, M.; Takanobu, K.; Senoh, H.; Saito, M.; Kondo, H.; Daghlian, G.; Hong, Y. K.; Yoshimatsu, Y.; Hirashima, M.; Kobashi, Y.; Okamoto, K.; Kishimoto, T.; Umeda, Y.

10.1101/2021.12.26.474221 — pharmacology and toxicology — Posted on 2022-01-07

3182 Selective whole genome amplification as a tool to enrich specimens with low Treponema pallidum genomic DNA copies for whole genome sequencing

Thurlow, C. M.; Joseph, S. J.; Ganova-Raeva, L. M.; Katz, S.; Pereira, L.; Chen, C.-Y.; Debra, A.; Vilfort, K.; Workowski, K.; Cohen, S.; Reno, H.; Sun, Y.; Burroughs, M.; Sheth, M.; Chi, K.-H.; Danavall, D.; Philip, S.; Cao, W.; Kersh, E.; Pillay, A.

10.1101/2021.07.09.451864 — genomics — Posted on 2022-01-07

3183 Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP)

Foley, G.; Mora, A.; Ross, C. M.; Bottoms, S.; Sutzl, L.; Lamprecht, M. L.; Zaugg, J.; Essebier, A.; Balderson, B.; Newell, R.; Thomson, R. E.; Kobe, B.; Barnard, R. T.; Guddat, L.; Schenk, G.; Carsten, J.; Gumulya, Y.; Rost, B.; Haltrich, D.; Sieber, V.; Gillam, E. M.; Boden, M.

10.1101/2019.12.30.891457 — bioinformatics — Posted on 2022-01-07

3184 Machine learning models based on molecular descriptors to predict human and environmental toxicological factors in continental freshwater

Servien, R.; Latrille, E.; Patureau, D.; Helias, A.

10.1101/2021.07.20.453034 — biochemistry — Posted on 2022-01-07

3185 Comparative whole plastome and low copy number phylogenetics of the core Saccharinae and Sorghinae.

Lloyd Evans, D.; Hughes, B.; Joshi, S. V.

10.1101/2022.01.04.474895 — evolutionary biology — Posted on 2022-01-07

3186 A novel form of macropinocytosis mediates ultra-rapid transfer of pathological alpha-synuclein to lysosomes

Bayati, A.; Banks, E.; Han, C.; Luo, W.; Zorca, C.; Reintsch, W. E.; Vanderperre, B.; McBride, H. M.; Fon, E. A.; Durcan, T. A.; McPherson, P. S.

10.1101/2022.01.06.475207 — cell biology — Posted on 2022-01-07

3187 Numerical methods for the detection of phase defect structures in excitable media

Kabus, D.; Arno, L.; Leenknegt, L.; Panfilov, A. V.; Dierckx, H.

10.1101/2021.12.16.473086 — systems biology — Posted on 2022-01-07

3188 Transbilayer Coupling of Lipids in Cells Investigated by Imaging Fluorescence Correlation Spectroscopy

Bag, N.; London, E.; Holowka, D. A.; Baird, B.

10.1101/2022.01.06.475300 — biophysics — Posted on 2022-01-07

3189 Lifetime of actin-dependent protein nanoclusters

Sarkar, S.; Goswami, D.

10.1101/2022.01.06.475299 — biophysics — Posted on 2022-01-07

3190 Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes

Ignatenko, O.; Malinen, S.; Vihinen, H.; Nikkanen, J.; Kononov, A.; Jokitalo, E.; Ince-Dunn, G.; Suomalainen, A.

10.1101/2021.08.24.457472 — neuroscience — Posted on 2022-01-07

3191 Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence

Anderson, S. R.; Roberts, J. M.; Ghena, N.; Irvin, E.; Schwakopf, J.; Cooperstein, I.; Bosco, A.; Vetter, M. L.

10.1101/2022.01.05.475126 — neuroscience — Posted on 2022-01-07

3192 Cas9 fusions for precision in vivo editing

Richardson, R. R.; Steyert, M.; Khim, S. N.; Romanowski, A. J.; Inen, J.; Altas, B.; Poulopoulos, A.

10.1101/2020.07.15.199620 — synthetic biology — Posted on 2022-01-07

3193 A novel metric reveals previously unrecognized distortion in dimensionality reduction of scRNA-Seq data

Cooley, S. M.; Hamilton, T.; Ray, J. C. J.; Deeds, E. J.

10.1101/689851 — bioinformatics — Posted on 2022-01-07

3194 High homozygosity of inversions in sunflower species largely averts accumulation of deleterious mutations

Huang, K.; Ostevik, K. L.; Elphinstone, C.; Todesco, M.; Bercovich, N.; Owens, G. L.; Rieseberg, L. H.

10.1101/2022.01.06.475294 — evolutionary biology — Posted on 2022-01-06

3195 A comprehensive approach for artifact-free sample preparation and assessment of mitochondrial morphology in tissue and cultured cells

Hinton, A.; Katti, P.; Christensen, T. A.; Mungai, M.; Shao, J.; Zhang, L.; Trushin, S.; Alghanem, A.; Jaspersen, A.; Geroux, R. E.; Neikirk, K.; Biete, M.; Garza Lopez, E.; Vue, Z.; Beasley, H.; Marshall, A.; Bleck, C. K. E.; Hicsasmaz, I.; Murray, S. A.; Edmonds, R. A. C.; Dajles, A.; Koo, Y. D.; Bacevac, S.; Salisbury, J. L.; Pereira, R. O.; Glancy, B.; Trushina, E.; Abel, E. D.

10.1101/2021.06.27.450055 — cell biology — Posted on 2022-01-07

3196 Emerin oligomerization and nucleoskeletal coupling at the nuclear envelope regulate nuclear mechanics against stress

Fernandez, A. M.; Bautista, M.; Wu, L.; Pinaud, F.

10.1101/2021.02.12.429834 — cell biology — Posted on 2022-01-07

3197 Kinetic principles underlying pioneer function of GAGA transcription factor in live cells

Tang, X.; Li, T.; Liu, S.; Wisniewski, J.; Zheng, Q.; Lavis, L.; Rong, Y.; Wu, C.

10.1101/2021.10.21.465351 — molecular biology — Posted on 2022-01-07

3198 Disruption of natural killer cell homing as a biomarker in persons aging with or without HIV

Kroll, K. W.; Shah, S. V.; Lucar, O.; Premeaux, T. A.; Shikuma, C. M.; Corley, M.; Mosher, M.; Bowler, S.; Ndhlovu, L.; Reeves, R. K.

10.1101/2022.01.05.475089 — immunology — Posted on 2022-01-07

3199 Supplementary motor area contributions to rhythm perception

Leow, L.-A.; Rinchon, C.; Emerick, M.; Grahn, J.

10.1101/2021.11.25.470060 — neuroscience — Posted on 2022-01-07

3200 Malformations of the sacculus and the semicircular canals in spider morph pythons

Starck, M. J.; Schrenk, F.; Sofia, S.; Pees, M.

10.1101/2022.01.06.475233 — zoology — Posted on 2022-01-06

3201 PhysiBoSS 2.0: a sustainable integration of stochastic Boolean and agent-based modelling frameworks

Ponce-de-Leon, M.; Montagud, A.; Noel, V.; Pradas, G.; Meert, A.; Barillot, E.; Calzone, L.; Valencia, A.

10.1101/2022.01.06.468363 — systems biology — Posted on 2022-01-06

3202 Reconstructing Kinetic Models for Dynamical Studies of Metabolism using Generative Adversarial Networks

Choudhury, S.; Moret, M.; Salvy, P.; Weilandt, D.; Hatzimanikatis, V.; Miskovic, L.

10.1101/2022.01.06.475020 — systems biology — Posted on 2022-01-06

3203 Characterization of a novel peptide mined from the Red Sea brine pools and modified to enhance its anticancer activity

Abdou, Y. T.; Saleeb, S. M.; Abdel-Raouf, K.; Allam, M.; Adel, M.; Amleh, A.

10.1101/2022.01.06.475234 — cancer biology — Posted on 2022-01-06

3204 Proteomic Dissection of a Giant Cell

Lin, A.; Piehowski, P.; Tsai, C.-F.; Makushok, T.; Yi, L.; Diaz, U.; Yan, C.; Summers, D.; Sood, P.; Smith, R.; Liu, T.; Marshall, W. F.

10.1101/2022.01.06.475287 — cell biology — Posted on 2022-01-06

3205 STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity

Ohishi, H.; Shimada, S.; Uchino, S.; Li, J.; Sato, Y.; Shintani, M.; Owada, H.; Ohkawa, Y.; Pertsinidis, A.; Yamamoto, T.; Kimura, H.; Ochiai, H.

10.1101/2022.01.06.472721 — molecular biology — Posted on 2022-01-06

3206 Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a pan-Ebolavirus Immunotherapeutic

Kuang, E.; Cross, R. W.; McCavitt-Malvido, M.; Abelson, D. M.; Borisevich, V.; Agans, K. N.; Mlakar, N.; Marimuthu, A.; Deer, D. J.; Shestowsky, W. S.; Kim, D.; Geisbert, J. B.; Zeitlin, L.; Moyer, C. L.; Roy, C. J.; Geisbert, T.; Bornholdt, Z. A.

10.1101/2022.01.06.475142 — microbiology — Posted on 2022-01-06

3207 Regulation of major bacterial survival strategies by transcript sequestration in a membraneless organelle

Szoke, T.; Albocher, N.; Goldberger, O.; Barsheshet, M.; Nussbaum-Shochat, A.; Wiener, R.; Schuldiner, M.; Amster-Choder, O.

10.1101/2022.01.06.475198 — microbiology — Posted on 2022-01-06

3208 MethylScore, a pipeline for accurate and context-aware identification of differentially methylated regions from population-scale plant WGBS data

Hüther, P.; Hagmann, J.; Nunn, A.; Kakoulidou, I.; Pisupati, R.; Langenberger, D.; Weigel, D.; Johannes, F.; Schultheiss, S. J.; Becker, C.

10.1101/2022.01.06.475031 — plant biology — Posted on 2022-01-06

3209 A Saturation-Mutagenesis Analysis of the Interplay Between Stability and Activation in Ras

Hidalgo, F.; Nocka, L. M.; Shah, N. H.; Gorday, K.; Latorraca, N. R.; Bandaru, P.; Templeton, S.; Lee, D.; Karandur, D.; Pelton, J. G.; Marqusee, S.; Wemmer, D.; Kuriyan, J.

10.1101/2022.01.06.475190 — biophysics — Posted on 2022-01-06

3210 Machine learning-assisted identification of factors contributing to the technical variability between bulk and single-cell RNA-seq experiments

Lipnitskaya, S.; Shen, Y.; Legewie, S.; Klein, H.; Becker, K.

10.1101/2022.01.06.474932 — bioinformatics — Posted on 2022-01-06

3211 Exploring novel fluorine rich fuberidazole derivatives as hypoxic cancer inhibitors: design, synthesis, pharmacokinetics, molecular docking and DFT evaluations

Taj, M. B.; Ali, O. M.

10.1101/2022.01.06.475235 — biochemistry — Posted on 2022-01-06

3212 Evaluating Human Mutation Databases for 'Treatability' Using Personalized Antisense Oligonucleotides

Gleeson, J. G.; Tang, I.; Mittal, S.

10.1101/2022.01.04.474998 — genetics — Posted on 2022-01-06

3213 Distinct responses to rare codons in select Drosophila tissues

Allen, S. R.; Stewart, R. K.; Rogers, M.; Ruiz, I. J.; Cohen, E.; Laederach, A.; Counter, C.; Sawyer, J. K.; Fox, D. T.

10.1101/2022.01.06.475284 — developmental biology — Posted on 2022-01-06

3214 Concurrent fMRI demonstrates propagation of TMS effects across task-related networks

Deng, L.; Gamboa, O. L.; Dannhauer, M.; Jonnalagadda, A.; Hamdan, R.; Crowell, C.; Worth, T.; Peterchev, A. V.; Sommer, M. A.; Cabeza, R.; Appelbaum, L. G.; Davis, S. W.

10.1101/2022.01.06.475293 — neuroscience — Posted on 2022-01-06

3215 Fibrin, Bone Marrow Cells and macrophages interactively modulate cardiomyoblast fate.

Borrego, I.; FROBERT, A.; AJALBERT, G.; VALENTIN, J.; KALTENRIEDER, C.; Fellay, B.; STUMPE, M.; Cook, S.; DENGJEL, J.; GIRAUD, M.-N.

10.1101/2022.01.06.475189 — physiology — Posted on 2022-01-06

3216 The CAR mRNA-Interaction Surface is a Zipper Extension of the Ribosome A Site

Dalgarno, C.; Scopino, K.; Raval, M.; Nachmanoff, C.; Sakkas, E.; Krizanc, D.; Thayer, K.; Weir, M. P.

10.1101/2022.01.06.475228 — biophysics — Posted on 2022-01-06

3217 Modeling Cell Biological Features of Meiotic Chromosome Pairing

Navarro, E. J.; Marshall, W. F.; Fung, J. C.

10.1101/2022.01.06.475288 — biophysics — Posted on 2022-01-06

3218 PLEKHA5 regulates mitotic progression by promoting APC/C localization to microtubules

Cao, X.; Shami Shah, A.; Sanford, E. J.; Smolka, M. B.; Baskin, J. M.

10.1101/2022.01.04.474939 — cell biology — Posted on 2022-01-06

3219 Inter-trial variations in EEG predict the individual differences in social tasks

Zhang, H.; Zhang, K.; Zhang, Z.; Zhao, M.; Liu, Q.; Luo, W.; Wu, H.

10.1101/2021.10.29.465647 — neuroscience — Posted on 2022-01-06

3220 Hierarchical Computational Anatomy: Unifying the Molecular to Tissue Continuum via Measure Representations of the Brain

Miller, M. I.; Tward, D. J.; Trouve, A.

10.1101/2021.04.19.440540 — neuroscience — Posted on 2022-01-06

3221 Mean-field approximation of network of biophysical neurons driven by conductance-based ion exchange

Bandyopadhyay, A.; bernard, c.; Jirsa, V.; Petkoski, S.

10.1101/2021.10.29.466427 — neuroscience — Posted on 2022-01-06

3222 A Large-Scale Investigation of White Matter Microstructural Associations with Reading Ability

Meisler, S. L.; Gabrieli, J. D. E.

10.1101/2021.08.26.456137 — neuroscience — Posted on 2022-01-06

3223 Chromosome 1q amplification perturbs a ceRNA network to promote melanoma metastasis

Xu, X.; Wang, K.; Vera, O.; Verma, A.; Elemento, O.; Yu, X.; Karreth, F. A.

10.1101/2021.11.14.468531 — cancer biology — Posted on 2022-01-06

3224 A generalised mechano-kinetic model for use in multiscale simulation protocols.

Hanson, B. S.; Read, D. J.; Dougan, L.; Harris, S. A.

10.1101/2020.11.17.386524 — biophysics — Posted on 2022-01-06

3225 Stem embolism vulnerability curve depends on methods used: is there a fifth mechanism of cavitation?

Peng, G.; Cao, L.; Ren, Z.; Liang, Z.; Yu, G.; Yang, D.; Tyree, M. T.

10.1101/2022.01.05.475122 — physiology — Posted on 2022-01-06

3226 A Computational Method to Dissect Colonization Resistance of the Gut Microbiota against Pathogens

Ke, S.; Xiao, Y.; Weiss, S. T.; Chen, X.; Kelly, C. P.; Liu, Y.-Y.

10.1101/2022.01.06.475215 — bioinformatics — Posted on 2022-01-06

3227 Supervised dimensionality reduction for exploration of single-cell data by Hybrid Subset Selection - Linear Discriminant Analysis

Amouzgar, M.; Glass, D. R.; Baskar, R.; Averbukh, I.; Kimmey, S. C.; Tsai, A. G.; Hartmann, F. J.; Bendall, S. C.

10.1101/2022.01.06.475279 — bioinformatics — Posted on 2022-01-06

3228 Joint copy number and mutation phylogeny reconstruction fromsingle-cell amplicon sequencing data

Sollier, E.; Kuipers, J.; Beerenwinkel, N.; Takahashi, K.; Jahn, K.

10.1101/2022.01.06.475205 — bioinformatics — Posted on 2022-01-06

3229 Chromosome-scale assembly of the highly heterozygous genome of red clover (Trifolium pratense L.), an allogamous forage crop species

Bickhart, D. M.; Koch, L. M.; Smith, T. P. L.; Riday, H.; Sullivan, M. L.

10.1101/2022.01.06.475143 — genomics — Posted on 2022-01-06

3230 Liver-derived cell lines from cavefish Astyanax mexicanus as an in vitro model for studying metabolic adaptation

Krishnan, J.; Wang, Y.; Kenzior, O.; Hassan, H.; Olsen, L.; Tsuchiya, D.; Wang, Y.; Zhao, C.; Rohner, N.

10.1101/2022.01.06.475101 — evolutionary biology — Posted on 2022-01-06

3231 Acquisition of cross-azole tolerance and aneuploidy in Candida albicans strains evolved to posaconazole

Kukurudz, R. J.; Chapel, M.; Wonitowy, Q.; Bukari, A.-R. A.; Sidney, B.; Sierhuis, R.; Gerstein, A.

10.1101/2022.01.06.475277 — evolutionary biology — Posted on 2022-01-06

3232 A unified view of LCRs across species

Lee, B.; Jaberi-Lashkari, N.; Calo, E.

10.1101/2022.01.06.475253 — cell biology — Posted on 2022-01-06

3233 Receptor interacting protein kinase-3 promotes both myopathy and cardiomyopathy in dystrophin-deficient mice

bencze, M.; Hou, C.; Periou, B.; Agbulut, O.; Gervais, M.; Ternacle, J.; Derumeaux, G.; Tiret, L.; Relaix, F.; Authier, F. J.

10.1101/2022.01.06.475271 — cell biology — Posted on 2022-01-06

3234 Exploring Functional Brain Network Modularity in Educational Contexts

Weinberger, A. B.; Cortes, R. A.; Betzel, R. F.; Green, A. E.

10.1101/2022.01.06.475275 — neuroscience — Posted on 2022-01-06

3235 Ramp-shaped neural tuning supports graded population-level representation of the object-to-scene continuum

Park, J.; Josephs, E.; Konkle, T.

10.1101/2022.01.06.475244 — neuroscience — Posted on 2022-01-06

3236 Examining the Neural Correlates of Error Awareness in a Large fMRI Study

Dali, G.; Brosnan, M. B.; Tiego, J.; Johnson, B.; Bellgrove, M.; Hester, R.

10.1101/2022.01.06.475224 — neuroscience — Posted on 2022-01-06

3237 Validation that human microbiome phages use alternative genetic coding with TAG stop read as Q

Peters, S.; Borges, A. L.; Giannone, R. J.; Morowitz, M.; Banfield, J.; Hettich, R.

10.1101/2022.01.06.475225 — systems biology — Posted on 2022-01-06

3238 Extracellular ATP plays an important role in systemic wound response activation

Myers, R.; Fichman, Y.; Stacey, G.; Mittler, R.

10.1101/2022.01.06.475278 — plant biology — Posted on 2022-01-06

3239 Integrative time-scale and multi-omic analysis of host-responses to Hop stunt viroid infection

Marquez-Molins, J.; Villalba-Bermell, P.; Corell-Sierra, J.; Pallas, V.; Gomez, G.

10.1101/2022.01.06.475203 — plant biology — Posted on 2022-01-06

3240 Dynamic changes in gas solubility of xylem sap reiterate the enigma of plant water transport under negative pressure

Pereira, L.; Jansen, S.; Miranda, M. T.; Pacheco, V. S.; Kaack, L.; Pires, G. S.; Guan, X.; Mayer, J. L.; Machado, E. C.; Schenk, H. J.; Ribeiro, R.

10.1101/2022.01.06.475193 — plant biology — Posted on 2022-01-06

3241 Cytokinin signalling regulates two-stage inflorescence arrest in Arabidopsis

Walker, C. H.; Ware, A.; Simura, J.; Ljung, K.; Wilson, Z. A.; Bennett, T.

10.1101/2022.01.06.475268 — plant biology — Posted on 2022-01-06

3242 Cross-talk between cAMP and Ca2+ signalling in cardiac pacemaker cells involves IP3-evoked Ca2+ release and stimulation of adenylyl cyclase 1

Bose, S. J.; Read, M.; Capel, R. A.; Akerman, E.; Ayagama, T.; Russell, A.; Terrar, D. A.; Zaccolo, M.; Burton, R. A. B.

10.1101/2022.01.06.475211 — pharmacology and toxicology — Posted on 2022-01-06

3243 Genome-wide SNPs of vegetable leafminer, Liriomyza sativae: insights into the recent Australian invasion

Xu, X.; Schmidt, T. L.; Liang, J.; Ridland, P. M.; Chung, J.; Yang, Q.; Jasper, M.; Umina, P. A.; Hoffmann, A. A.

10.1101/2022.01.06.475194 — bioinformatics — Posted on 2022-01-06

3244 Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning

Coyote-Maestas, W.; Nedrud, D.; He, Y.; Schmidt, D.

10.1101/2022.01.06.475280 — biochemistry — Posted on 2022-01-06

3245 Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

Bibel, B.; Elkayam, E.; Silletti, S.; Komives, E. A.; Joshua-Tor, L.

10.1101/2022.01.06.475261 — biochemistry — Posted on 2022-01-06

3246 Maternal investment evolves with larger body size and higher diversification rate in sharks and rays

Mull, C. G.; Pennell, M. W.; Yopak, K. E.; Dulvy, N. K.

10.1101/2022.01.05.475057 — evolutionary biology — Posted on 2022-01-06

3247 Ghost lineages invalidate or reverse several results on gene flow

Tricou, T.; Tannier, E.; de Vienne, D. M.

10.1101/2022.01.06.475184 — evolutionary biology — Posted on 2022-01-06

3248 Assessing Bayesian Phylogenetic Information Content of Morphological Data Using Knowledge from Anatomy Ontologies

Sasso Porto, D.; Dahdul, W.; Lapp, H.; Balhoff, J.; Vision, T.; Mabee, P.; Uyeda, J.

10.1101/2022.01.06.475250 — evolutionary biology — Posted on 2022-01-06

3249 GO WIDE TO GO DEEP: AFFORDABLE, REPLICABLE ROBOTIC MINIRHIZOTRON SAMPLING FOR PHENOLOGY STUDIES

Nair, R.; Strube, M.; Hertel, M.; Kolle, O.; Reichstein, M.; Migliavacca, M.

10.1101/2022.01.06.475082 — ecology — Posted on 2022-01-06

3250 Multifunctional role of GPCR signaling in epithelial tube formation

Vishwakarma, V.; Le, T. P.; Chung, S.

10.1101/2022.01.06.475238 — developmental biology — Posted on 2022-01-06

3251 The biosynthetic-secretory pathway, supplemented by recycling routes, specifies epithelial membrane polarity

Zhang, N.; Zhang, H.; Khan, L. A.; Jafari, G.; Eun, Y.; Membreno, E.; Gobel, V.

10.1101/2022.01.06.475118 — cell biology — Posted on 2022-01-06

3252 Moment-Based Estimation of State-Switching Rates in Cell Populations

Saint-Antoine, M. M.; Singh, A.

10.1101/2022.01.06.475260 — cell biology — Posted on 2022-01-06

3253 Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

Shi, G.; Chiramel, A. I.; Majdoul, S.; Lai, K. K.; Dempsey, T.; Kenney, A.; Zani, A.; Eddy, A.; Zhang, L.; Das, S.; Beare, P. A.; Andresson, T.; Kar, S.; Yount, J. S.; Best, S. M.; Compton, A. A.

10.1101/2021.04.15.440067 — microbiology — Posted on 2022-01-06

3254 Sex-specific distribution and classification of Wolbachia infections and mitochondrial DNA haplogroups in Aedes albopictus from the Indo-Pacific

Yang, Q.; Chung, J.; Robinson, K.; Schmidt, T. L.; Ross, P.; Liang, J.; Hoffmann, A.

10.1101/2022.01.05.475177 — microbiology — Posted on 2022-01-06

3255 Protection of Hamsters Challenged with SARS-CoV-2 Variants of Concern by Two Doses of MVC-COV1901 Vaccine Followed by a Single Dose of Beta Variant Version of MVC-COV1901

Kuo, T.-Y.; Lien, C.-E.; Lin, Y.-J.; Lin, M.-Y.; Wu, C.-C.; Tang, W.-H.; Campbell, J. D.; Traquina, P.; Chuang, Y.-S.; Liu, L. T. C.; Cheng, J.; Chen, C.

10.1101/2021.09.29.462344 — immunology — Posted on 2022-01-06

3256 Release of acidic store calcium is required for effective priming of the NLRP3 inflammasome

Platt, N.; Shepherd, D.; Weng, Y.; Churchill, G. C.; Galione, A.; Platt, F. M.

10.1101/2022.01.06.475262 — immunology — Posted on 2022-01-06

3257 Neuromaps: structural and functional interpretation of brain maps

Markello, R. D.; Hansen, J. Y.; Liu, Z.-Q.; Bazinet, V.; Shafiei, G.; Suarez, L. E.; Blostein, N.; Seidlitz, J.; Baillet, S.; Satterthwaite, T. D.; Chakravarty, M.; Raznahan, A.; Misic, B.

10.1101/2022.01.06.475081 — neuroscience — Posted on 2022-01-06

3258 Individual coactivation patterns improve the subject identification and their behavior association

Yang, H.; Yao, X.; Zhang, H.; Meng, C.; Biswal, B. B.

10.1101/2022.01.06.475181 — neuroscience — Posted on 2022-01-06

3259 Neural correlate of reduced respiratory chemosensitivity during chronic epilepsy

Bhandare, A.; Dale, N.

10.1101/2022.01.06.475212 — neuroscience — Posted on 2022-01-06

3260 Concomitant AD and DLB pathologies shape subfield microglia responses in the hippocampus

Fixemer, S.; Ameli, C.; Hammer, G. P.; Salamanca, L. M.; Huarte, O. U.; Schwartz, C.; Gerardy, J.-J.; Mechawar, N.; Skupin, A.; Mittelbronn, M.; Bouvier, D. S.

10.1101/2022.01.06.475218 — neuroscience — Posted on 2022-01-06

3261 Synchronization in the connectome: Metastable oscillatory modes emerge from interactions in the brain spacetime network

Cabral, J.; Castaldo, F.; Vohryzek, J.; Litvak, V.; Bick, C.; Lambiotte, R.; Friston, K.; Kringelbach, M. L.; Deco, G.

10.1101/2022.01.06.475196 — neuroscience — Posted on 2022-01-06

3262 An emergent temporal basis set robustly supports cerebellar time-series learning

Gilmer, J. I.; Farries, M. A.; Kilpatrick, Z. P.; Delis, I.; Person, A. L.

10.1101/2022.01.06.475265 — neuroscience — Posted on 2022-01-06

3263 Fast event-related mapping of fingertip population receptive fields in human somatosensory and motor cortex

Khalife, S.; Francis, S. T.; Schluppeck, D.; Sanchez-Panchuelo, R.-M.; Besle, J.

10.1101/2022.01.06.471906 — neuroscience — Posted on 2022-01-06

3264 Random Compressed Coding with Neurons

Blanco Malerba, S.; Pieropan, M.; Burak, Y.; Azeredo da Silveira, R.

10.1101/2022.01.06.475186 — neuroscience — Posted on 2022-01-06

3265 The principal mitochondrial K+ uniport is associated with respiratory complex I

Zemel, M.; Angelin, A.; Potluri, P.; Wallace, D.; Fieni, F.

10.1101/2022.01.06.475251 — physiology — Posted on 2022-01-06

3266 Stimulating the sir2-pgc-1α axis rescues exercise capacity and mitochondrial respiration in Drosophila tafazzin mutants.

Damschroder, D.; Zapata-Perez, R.; Houtkooper, R. H.; Wessells, R.

10.1101/2022.01.06.475267 — physiology — Posted on 2022-01-06

3267 LIX1 controls digestive mesenchyme-derived cell fate decision by regulating cristae organization in mitochondria

Guerin, A.; Angebault, C.; Kinet, S.; Cazevieille, C.; Rojo, M.; Fauconnier, J.; Lacampagne, A.; Mourier, A.; Taylor, N.; de Santa Barbara, P.; Faure, S.

10.1101/2022.01.06.475258 — cancer biology — Posted on 2022-01-06

3268 Cytocapsular tubes and networks function as physical superdefence freeway systems conducting conventional cancer drug pan-resistant tumor metastasis

Yi, T.; Wagner, G.

10.1101/2022.01.05.475158 — cancer biology — Posted on 2022-01-06

3269 Bias in FGFR1 signaling in response to FGF4, FGF8, and FGF9

Karl, K. A.; Hristova, K.; Krejci, P.; Del Piccolo, N.

10.1101/2022.01.06.475273 — biophysics — Posted on 2022-01-06

3270 Development and Validation of Fluorinated Amino Acid Parameters for use with the AMBER ff15ipq Protein Force Field

Yang, D.; Gronenborn, A.; Chong, L.

10.1101/2022.01.06.475229 — biophysics — Posted on 2022-01-06

3271 GFAP: ultra-fast and accurate gene functional annotation software for plants

Xu, D.; Jin, K.; Jiang, H.; Gong, D.; Yang, J.; Yu, W.; Yang, Y.; Li, J.; Pan, W.

10.1101/2022.01.05.475154 — bioinformatics — Posted on 2022-01-06

3272 Treatment of wound infections in a mouse model using Zn2+-releasing phage bound to gold nanorods

PENG, H.; Rossetto, D.; Mansy, S.; Jordan, M.; Roos, K.; Chen, I.

10.1101/2022.01.05.475129 — bioengineering — Posted on 2022-01-06

3273 Feasibility of Using Wearable EMG Armbands combined with Unsupervised Transfer Learning for Seamless Myoelectric Control

Sohn, M. H.; Lai, S. Y.; Elwin, M. L.; Dewald, J. P. A.

10.1101/2022.01.06.475232 — bioengineering — Posted on 2022-01-06

3274 An Extended Motif in the SARS-CoV-2 Spike Modulates Binding and Release of Host Coatomer in Retrograde Trafficking

Dey, D.; Singh, S.; Khan, S.; Martin, M.; Schnicker, N.; Gakhar, L.; Pierce, B.; Hasan, S. S.

10.1101/2021.09.03.458953 — biochemistry — Posted on 2022-01-06

3275 Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization

Pesenti, M. E.; Raisch, T.; Conti, D.; Hoffmann, I.; Vogt, D.; Prumbaum, D.; Vetter, I. R.; Raunser, S.; Musacchio, A.

10.1101/2022.01.06.475204 — biochemistry — Posted on 2022-01-06

3276 Redirecting RiPP biosynthetic enzymes to proteins and backbone-modified substrates

Walker, J. A.; Hamlish, N.; Tytla, A.; Brauer, D. D.; Francis, M. B.; Schepartz, A.

10.1101/2022.01.05.475141 — biochemistry — Posted on 2022-01-06

3277 Statistical analysis reveals the onset of synchrony in sparse swarms of Photinus knulli fireflies

Sarfati, R.; Gaudette, L.; Cicero, J.; Peleg, O.

10.1101/2022.01.05.475109 — animal behavior and cognition — Posted on 2022-01-06

3278 Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland

Hou, H.; Chan, C.; Yuki, K. E.; Sokolowski, D.; Roy, A.; Qu, R.; Uuskula-Reimand, L.; Faykoo-Martinez, M.; Hudson, M.; Corre, C.; Goldenberg, A.; Zhang, Z.; Palmert, M. R.; Wilson, M. D.

10.1101/2022.01.05.475069 — genomics — Posted on 2022-01-06

3279 Sperm exposure to accessory gland secretions alters the transcriptomic response of the endometrium in cattle

Sanchez, J. M.; Rabaglino, M. B.; Bages-Arnal, S.; McDonald, M.; Behura, S. K.; Spencer, T. E.; Lonergan, P.; Fernandez-Fuertes, B.

10.1101/2022.01.06.475202 — genomics — Posted on 2022-01-06

3280 Shrimp draft genome contains independent clusters of ancient and current endogenous viral elements (EVE) of the parvovirus IHHNV

Taengchaiyaphum, S.; Wongkhaluang, P.; Flegel, T. W.; Sritunyalucksana, K.

10.1101/2021.12.29.474436 — genetics — Posted on 2022-01-06

3281 Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease

Wilson, R.; Yuan, V.; Courtney, J. A.; Tipler, A.; Cnota, J.; Jones, H.

10.1101/2022.01.06.475249 — genetics — Posted on 2022-01-06

3282 Effects of recombination on the evolvability, genetic diversity and mutational robustness of neutrally evolving populations

Krug, J.; Klug, A.

10.1101/2022.01.05.475123 — evolutionary biology — Posted on 2022-01-06

3283 THEWEIGHT: A simple and flexible algorithm for simulating non-ideal, age-structured populations

Waples, R. S.

10.1101/2022.01.05.475135 — evolutionary biology — Posted on 2022-01-06

3284 The Emergence of the Metabolic Signaling of the Nucleoredoxin-like Genes during Evolution

Ait-Ali, N.; Blond, F.; Clerin, E.; Morshedian, A.; Cesar, Q.; Delalande, F.; Koyanagi, M.; Birck, C.; Han, J.; Ren, X.; Dorsselaer, A.; Terakita, A.; Fain, G.; Leveillard, T.

10.1101/2022.01.06.475223 — evolutionary biology — Posted on 2022-01-06

3285 Acetyl-CoA mediated autoacetylation of fatty acid synthase in de novo lipogenesis

Miao, T.; Kim, J.; Kang, P.; Bai, H.

10.1101/2022.01.06.475252 — developmental biology — Posted on 2022-01-06

3286 RETINOBLASTOMA RELATED (RBR) interaction with key factors of the RNA-directed DNA methylation (RdDM) pathway

Ruiz-Leon, J.; Espinal-Centeno, A.; Blilou, I.; Scheres, B.; Arteaga-Vazquez, M.; Cruz-Ramirez, A.

10.1101/2022.01.06.474281 — developmental biology — Posted on 2022-01-06

3287 Toxoplasma ceramide synthases: a curious case of gene duplication, divergence and key functionality

Koutsogiannis, Z.; Mina, J.; Albus, C.; Kol, M.; Holthuis, J.; Pohl, E.; Denny, P.

10.1101/2022.01.05.475179 — microbiology — Posted on 2022-01-06

3288 DWV 3C protease uncovers the diverse catalytic triad in insect RNA viruses

Yuan, X.; Kadowaki, T.

10.1101/2022.01.06.475182 — microbiology — Posted on 2022-01-06

3289 A blunted GPR183/oxysterol axis during dysglycemia results in delayed recruitment of macrophages to the lung during M. tuberculosis infection

Ngo, M. D.; Bartlett, S.; Bielefeldt-Ohmann, H.; Foo, C. X.; Sinha, R.; Arachchige, B. J.; Reed, S. J.; Mandrup-Poulsen, T.; Rosenkilde, M. M.; Ronacher, K.

10.1101/2022.01.05.475168 — immunology — Posted on 2022-01-06

3290 Disruption of natural killer cell homing as a biomarker in persons aging with or without HIV

Kroll, K. W.; Shah, S. V.; Lucar, O.; Premeaux, T. A.; Shikuma, C. M.; Corley, M.; Mosher, M.; Bowler, S.; Ndhlovu, L.; Reeves, R. K.

10.1101/2022.01.05.475089 — immunology — Posted on 2022-01-06

Srivastava, R.; Agrawal, A.; Vahed, H.; BenMohamed, L.

10.1101/2022.01.05.475170 — immunology — Posted on 2022-01-06

3292 Dysfunctional Senescent Herpes Simplex Virus Specific CD57+CD8+ T cells are Associated with Recurrent Symptomatic Herpes in Humans

BenMohamed, L.; Khan, A. A.; Srivastava, R.; Vahed, H.

10.1101/2022.01.05.475169 — immunology — Posted on 2022-01-06

3293 Resolution and b value dependent Structural Connectome in ex vivo Mouse Brain

Crater, S.; Maharjan, S.; Qi, Y.; Zhao, Q.; Cofer, G.; Cook, J. J.; Johnson, G. A.; Wang, N.

10.1101/2022.01.05.474963 — neuroscience — Posted on 2022-01-06

3294 Chronic Cognitive and Cerebrovascular Function Following Mild Traumatic Brain Injury in Rats

Griffiths, D. R.; Law, L. M.; Young, C.; Fuentes, A.; Truran, S.; Karamanova, N.; Bell, L. C.; Turner, G.; Emerson, H.; Mastroeni, D.; Gonzales, R.; Reaven, P. D.; Quarles, C. C.; Migrino, R. Q.; Lifshitz, J.

10.1101/2022.01.05.474992 — neuroscience — Posted on 2022-01-06

3295 scRNA-sequencing reveals subtype-specific transcriptomic perturbations in DRG neurons of Pirt-EGFPf mice in neuropathic pain condition

Zhang, C.; Hu, M.-W.; He, S.; Wang, X.; Cao, X.; Zhou, F.; Qian, J.; Guan, Y.

10.1101/2022.01.06.475187 — neuroscience — Posted on 2022-01-06

3296 A novel method for multi-scale recording of intracranial EEG through dynamic alteration of electrode surface area

Remakanthakarup Sindhu, K.; Ngo, D.; Ombao, H.; Olaya, J. E.; Shrey, D. W.; Lopour, B. A.

10.1101/2022.01.05.475164 — neuroscience — Posted on 2022-01-06

3297 Resonant waves drive long-range correlations in fMRI signals

Cabral, J.; Fernandes, F. F.; Shemesh, N.

10.1101/2022.01.06.475200 — neuroscience — Posted on 2022-01-06

3298 Loss of pod strings in common bean is associated with gene duplication, retrotransposon insertion, and overexpression of PvIND

Parker, T.; Cetz, J.; de Sousa, L. L.; Kuzay, S.; Lo, S.; Floriani, T. d. O.; Njau, S. N.; Arunga, E. E.; Duitama, J.; Jernstedt, J.; Myers, J.; Llaca, V.; Herrera-Estrella, A.; Gepts, P.

10.1101/2022.01.05.475151 — plant biology — Posted on 2022-01-06

3299 Hantaan virus replication is promoted via AKT activated mitochondria OXPHOS

Dong, Y.; Zhang, X.; Li, M.; Ying, Q.; Feng, Y.; Li, Z.; Wu, X.-a.; Wang, F.

10.1101/2022.01.05.475173 — pathology — Posted on 2022-01-06

3300 Development of OPLS-AA/M Parameters for Simulations of G Protein-Coupled Receptors and Other Membrane Proteins

Robertson, M. J.; Skiniotis, G.

10.1101/2022.01.05.475148 — biophysics — Posted on 2022-01-06

3301 dsSurvival: Privacy preserving survival models for federated individual patient meta-analysis in DataSHIELD

Banerjee, S.; Sofack, G.; Papakonstantinou, T.; Avraam, D.; Burton, P.; Zöller, D.; Bishop, T. R.

10.1101/2022.01.04.471418 — bioinformatics — Posted on 2022-01-06

3302 MvPPT: a highly efficient and sensitive pathogenicity prediction tool for missense variants

Tong, S.; Fan, K.; Zhou, Z.-W.; Liu, L.-Y.; Zhang, S.-Q.; Fu, Y.; Wang, G.-Z.; Zhu, Y.; Yu, Y.-C.

10.1101/2022.01.05.475156 — bioinformatics — Posted on 2022-01-06

3303 Regulating bacterial behavior within hydrogels of tunable viscoelasticity

Bhusari, S.; Sankaran, S.; del Campo, A.

10.1101/2022.01.06.475183 — bioengineering — Posted on 2022-01-06

3304 Dissolvable microgel-templated macroporous hydrogels for controlled cell assembly

Jiang, Z.; Lin, F.-Y.; Jiang, K.; Nguyen, H.; Chang, C.-Y.; Lin, C.-C.

10.1101/2022.01.05.475155 — bioengineering — Posted on 2022-01-06

3305 Linked-Read Sequencing of Eight Falcons Reveals a Unique Genomic Architecture in Flux

Wilcox, J.; Arca-Ruibal, B.; Samour, J.; Mateuta, V.; Idaghdour, Y.; Boissinot, S.

10.1101/2022.01.05.468466 — genomics — Posted on 2022-01-06

3306 Genomic signatures of isolation, hybridization, and selection during speciation of island finches

Stervander, M.; Melo, M.; Jones, P.; Hansson, B.

10.1101/2022.01.05.474904 — evolutionary biology — Posted on 2022-01-06

3307 Unravelling microalgal-bacterial interactions in aquatic ecosystems through 16S co-occurrence networks

Pushpakumara, B. L. D. U.; Tandon, K.; Willis, A.; Verbruggen, H.

10.1101/2022.01.05.475147 — ecology — Posted on 2022-01-06

3308 Genome characteristic of Bordetella parapertussis isolated from Iran

Safarchi, A.; Saedi, S.; Tay, C. Y.; Lamichhan, B.; Nakhost Lotfi, M.; Shahgheraghi, F.

10.1101/2022.01.05.475152 — microbiology — Posted on 2022-01-06

3309 IKKalpha-Mediated Non-canonical NF-kappaB Signaling is Required to Support Murine Gammaherpesvirus 68 Latency In Vivo

Cieniewicz, B.; Kirillov, V.; Daher, I.; Li, X.; Oldenburg, D. G.; Dong, Q.; Bettke, J. A.; Marcu, K. B.; Krug, L. T.

10.1101/2022.01.05.475165 — microbiology — Posted on 2022-01-06

3310 Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence

Anderson, S. R.; Roberts, J. M.; Ghena, N.; Irvin, E.; Schwakopf, J.; Cooperstein, I.; Bosco, A.; Vetter, M. L.

10.1101/2022.01.05.475126 — neuroscience — Posted on 2022-01-06

3311 Synaptic plasticity of inhibitory synapses onto medial olivocochlear efferent neurons

Cadenas, L. T.; Cheng, H.; Weisz, C. J. C.

10.1101/2022.01.05.475100 — neuroscience — Posted on 2022-01-06

3312 Where we perceive before we look: The distribution of presaccadic attention assessed with dynamic 1/f noise

Hanning, N. M.; Deubel, H.

10.1101/2022.01.05.475160 — neuroscience — Posted on 2022-01-06

3313 Serine 1283 in extracellular matrix glycoprotein Reelin is crucial for Reelin's function in brain development

Kleene, R.; Loers, G.; Sharaf, A.; Wang, S.; Kataria, H.; Anstoetz, M.; Hermans-Borgmeyer, I.; Schachner, M.

10.1101/2022.01.06.474241 — neuroscience — Posted on 2022-01-06

3314 A western representative of an eastern clade: phylogeographic history of the gypsophilous plant Nepeta hispanica

Ramos-Gutierrez, I.; Moreno Saiz, J. C.; Fernandez-Mazuecos, M.

10.1101/2022.01.05.475097 — plant biology — Posted on 2022-01-06

3315 Tiling mechanisms of the compound eye through geometrical tessellation

Sato, M.; Hayashi, T.; Tomomizu, T.; Sushida, T.; Akiyama, M.; Ei, S.-I.

10.1101/2022.01.05.475162 — developmental biology — Posted on 2022-01-06

3316 Generation of rat lungs by blastocyst complementation in Fgfr2b-deficient mouse model

Yuri, S.; Murase, Y.; Isotani, A.

10.1101/2022.01.05.475149 — developmental biology — Posted on 2022-01-06

3317 A novel form of macropinocytosis mediates ultra-rapid transfer of pathological alpha- synuclein to lysosomes

Bayati, A.; Banks, E.; Han, C.; Luo, W.; Zorca, C.; Reintsch, W. E.; Vanderperre, B.; McBride, H. M.; Fon, E. A.; Durcan, T. A.; McPherson, P. S.

10.1101/2022.01.06.475207 — cell biology — Posted on 2022-01-06

3318 Plant peptidoglycan precursor biosynthesis: Conservation between moss chloroplasts and Gram negative bacteria

Dowson, A. J.; Lloyd, A. J.; Cuming, A. C.; Roper, D. I.; Frigerio, L.; Dowson, C. G.

10.1101/2022.01.05.475093 — evolutionary biology — Posted on 2022-01-06

3319 Spatial scales of competition and a growth-motility tradeoff interact to determine bacterial coexistence

Kuhn, T.; Mamin, M.; Bindschedler, S.; Bshary, R.; Estoppey, A.; Gonzalez, D.; Palmieri, F.; Junier, P.; Richter, X.-Y. L.

10.1101/2022.01.05.474435 — ecology — Posted on 2022-01-06

3320 HLJ1 amplifies endotoxin-induced sepsis severity by promoting IL-12 heterodimerization in macrophages

Luo, W.-J.; Yu, S.-L.; Chang, C.-C.; Chien, M.-H.; Liao, K.-M.; Chang, Y.-L.; Chuang, Y.-H.; Chen, J. J. W.; Yang, P.-C.; Su, K.-Y.

10.1101/2022.01.05.475083 — immunology — Posted on 2022-01-06

3321 Phosphate transporter PHT1;1 as a key determinant of phosphorus acquisition in Arabidopsis natural accessions

Chien, P.-S.; Chao, Y.-T.; Chou, C.-H.; Hsu, Y.-Y.; Chiang, S.-F.; Tung, C.-W.; Chiou, T.-J.

10.1101/2022.01.05.475091 — plant biology — Posted on 2022-01-06

3322 Alternative splicing analysis benchmark with DICAST

Fenn, A. M.; Tsoy, O.; Faro, T.; Roessler, F.; Dietrich, A.; Kersting, J.; Louadi, Z.; Lio, C. T.; Voelker, U.; Baumbach, J.; Kacprowski, T.; List, M.

10.1101/2022.01.05.475067 — bioinformatics — Posted on 2022-01-06

3323 Applied phenomics and genomics for improving barley yellow dwarf resistance in winter wheat

Silva, P.; Evers, B.; Kieffaber, A.; Wang, X.; Brown, R.; Gao, L.; Fritz, A. K.; Crain, J.; Poland, J.

10.1101/2022.01.05.475073 — genetics — Posted on 2022-01-06

3324 Relaxed risk of predation drives parallel evolution of stickleback behaviour

Fraimout, A.; Päiviö, E.; Merilä, J.

10.1101/2022.01.05.475046 — evolutionary biology — Posted on 2022-01-06

3325 Climatic niche conservatism in a clade of disease vectors (Diptera: Phlebotominae)

D'Agostino, E. R. R.; Vivero, R.; Romero, L.; Bejarano, E.; Hurlbert, A. H.; Comeault, A. A.; Matute, D. R.

10.1101/2022.01.05.475052 — evolutionary biology — Posted on 2022-01-06

3326 Humanization of wildlife gut microbiota in urban environments

Dillard, B. A.; Chung, A. K.; Gunderson, A. R.; Campbell-Staton, S. C.; Moeller, A. H.

10.1101/2022.01.05.475040 — ecology — Posted on 2022-01-06

3327 Characterization of alveolar epithelial lineage heterogeneity during the late pseudoglandular stage of mouse lung development

Jones, M.; Chong, L.; Lingampally, A.; Wilhelm, J.; Ansari, M.; Schiller, H. B.; Carraro, G.; Bellusci, S.

10.1101/2022.01.05.475053 — developmental biology — Posted on 2022-01-06

3328 Injury suppresses Ras cell competitive advantage through enhanced wild-type cell proliferation

Gallini, S.; Rahman, N.-T.; Annusver, K.; Gonzalez, D. G.; Yun, S.; Matte-Martone, C.; Xin, T.; Lathrop, E.; Suozzi, K. C. S. C.; Kasper, M.; Greco, V.

10.1101/2022.01.05.475078 — cell biology — Posted on 2022-01-06

3329 Differential serotonergic modulation of principal neurons and interneurons in the anterior piriform cortex

Lorincz, M. L.; Piszar, I.

10.1101/2022.01.05.475043 — neuroscience — Posted on 2022-01-06

3330 An efficient multi-scale CNN model with intrinsic feature integration for motor imagery EEG subject classification in brain-machine interfaces

Roy, A. M.

10.1101/2022.01.05.475058 — neuroscience — Posted on 2022-01-06

3331 Analytical time-dependent distributions for gene expression models with complex promoter switching mechanisms

Jia, C.; Li, Y.

10.1101/2022.01.05.475050 — systems biology — Posted on 2022-01-06

3332 Machine learning guided batched design of a bacterial Ribosome Binding Site

Zhang, M.; Holowko, M. B.; Zumpe, H. H.; Ong, C. S.

10.1101/2022.01.05.475140 — synthetic biology — Posted on 2022-01-06

3333 Lack of evidence for functional luteinising hormone chorionic gonadotropin receptors in non-pregnant human endometrial stromal cells

Mann, O. N.; Kong, C.-S.; Lucas, E. S.; Brosens, J. J.; Hanyaloglu, A. C.; Brighton, P. J.

10.1101/2022.01.05.474837 — pharmacology and toxicology — Posted on 2022-01-06

3334 A novel computational method for head-to-tail peptide cyclization: application to urotensin II

Karami, Y.; Murail, S.; Giribaldi, J.; Lefranc, B.; Leprince, J.; de Vries, S.; Tuffery, P.

10.1101/2022.01.05.475045 — bioinformatics — Posted on 2022-01-06

3335 Choice can be predicted from populations of bursting neurons in superficial layers of monkey V1

Koren, V.; Andrei, A. R.; Hu, M.; Dragoi, V.; Obermayer, K.

10.1101/2020.01.10.901504 — neuroscience — Posted on 2022-01-06

3336 Protein Complex Structure Prediction Powered by Multiple Sequence Alignments of Interologs from Multiple Taxonomic Ranks and AlphaFold2

Si, Y.; Yan, C.

10.1101/2021.12.21.473437 — bioinformatics — Posted on 2022-01-06

3337 Endogenous retroviruses co-opted as divergently transcribed regulatory elements shape the regulatory landscape of embryonic stem cells

Bakoulis, S.; Krautz, R.; Alcaraz, N.; Salvatore, M.; Andersson, R.

10.1101/2021.06.11.448013 — genomics — Posted on 2022-01-06

3338 Opposite roles of Rad5 in DNA damage tolerance: playing in both error-free and mutagenic lesion bypass

Maslowska, K. H.; Pages, V.

10.1101/2022.01.06.475185 — molecular biology — Posted on 2022-01-06

3339 Inter-trial Variations in EEG predict the individual differences in social tasks

Zhang, H.; Zhang, K.; Zhang, Z.; Zhao, M.; Liu, Q.; Luo, W.; Wu, H.

10.1101/2021.10.29.465647 — neuroscience — Posted on 2022-01-06

3340 Light-driven biological actuators to probe the rheology of 3D microtissues

Mery, A.; Ruppel, A.; Revilloud, J.; Balland, M.; Cappello, G.; Boudou, T.

10.1101/2022.01.05.475039 — biophysics — Posted on 2022-01-06

3341 Reliable cell retention of mammalian suspension cells in microfluidic cultivation chambers

Schmitz, J.; Stute, B.; Taeuber, S.; Kohlheyer, D.; von Lieres, E.; Gruenberger, A.

10.1101/2022.01.05.475060 — bioengineering — Posted on 2022-01-06

3342 CRISPR/Cas9 knock-in strategy to evaluate phospho-regulation of SAMHD1

Schüssler, M.; Rauch, P.; Schott, K.; Oo, A.; Fuchs, N. V.; Kim, B.; König, R.

10.1101/2022.01.04.475018 — microbiology — Posted on 2022-01-06

3343 Apical and basal auxin sources pattern shoot branching in a moss

Thelander, M.; Landberg, K.; Muller, A. R. J.; Cloarec, G.; Cunniffe, N.; Huguet, S.; Soubigou-Taconnat, L.; Brunaud, V.; Coudert, Y.

10.1101/2022.01.04.474977 — plant biology — Posted on 2022-01-06

3344 Red blood cells protein profile is modified in breast cancer patients

Pereira-Viega, T.; Bravo, S. B.; Gomez-Tato, A.; Yanez-Gomez, C.; Abuin, C.; Varela, V.; Cueva, J.; Palacios, P.; Davila-Ibanez, A. B.; Pineiro, R.; Vilar, A.; Chantada-Vazquez, M. P.; Lopez-Lopez, R.; Costa, C.

10.1101/2022.01.04.474889 — cancer biology — Posted on 2022-01-06

3345 CRISPR-LRS for mapping transgenes in the mouse genome

Bryant, W. B.; Yang, A.; Griffin, S.; Zhang, W.; Long, X.; Miano, J. M.

10.1101/2022.01.05.475144 — genetics — Posted on 2022-01-06

3346 The NF-κB pathway regulates heterochromatin at intronic young LINE-1 elements and hematopoietic stem cell gene expression during irradiation stress

Pelinski, Y.; Hidaoui, D.; Stolz, A.; Hermetet, F.; Chelbi, R.; Diop, M. K.; Chioukh, A.; Porteu, F.; Elvira-Matelot, E.

10.1101/2021.06.08.447574 — cell biology — Posted on 2022-01-06

3347 Correlative all-optical quantification of mass density and mechanics of sub-cellular compartments with fluorescence specificity

Schlüssler, R.; Kim, K.; Nötzel, M.; Taubenberger, A. V.; Abuhattum, S.; Beck, T.; Müller, P.; Maharana, S.; Cojoc, G.; Girardo, S.; Hermann, A.; Alberti, S.; Guck, J.

10.1101/2020.10.30.361808 — biophysics — Posted on 2022-01-06

3348 Joint dimension reduction and clustering analysis for single-cell RNA-seq and spatial transcriptomics data

Liu, W.; Liao, X.; Zhou, X.; Shi, X.; Liu, J.

10.1101/2021.12.25.474153 — genomics — Posted on 2022-01-06

3349 Multiple hybridization events punctuate the evolutionary trajectory of Malassezia furfur

Theelen, B.; Mixao, V.; Ianiri, G.; Goh, J. P. Z.; Dijksterhuis, J.; Heitman, J.; Dawson, T. L.; Gabaldon, T.; Boekhout, T.

10.1101/2021.11.02.466935 — evolutionary biology — Posted on 2022-01-06

3350 Shaping sustainable harvest boundaries for marine populations despite estimation bias

Goto, D.; Devine, J.; Umar, I.; Fischer, S.; De Oliveira, J.; Howell, D.; Jardim, E.; Mosqueira, I.; Ono, K.

10.1101/2020.12.05.413070 — ecology — Posted on 2022-01-06

3351 Identification of a novel cationic glycolipid in Streptococcus agalactiae that contributes to brain entry and meningitis

Joyce, L. R.; Manzer, H. S.; da C. Mendonca, J.; Villarreal, R.; Nagao, P. E.; Doran, K. S.; Palmer, K. L.; Guan, Z.

10.1101/2020.12.01.406702 — microbiology — Posted on 2022-01-06

3352 Word structure tunes electrophysiological and hemodynamic responses in the frontal cortex

Gao, F.; Hua, L.; He, Y.; Yuan, Z.

10.1101/2021.11.14.468513 — neuroscience — Posted on 2022-01-06

3353 Programmed knockout mutation of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic opisthorchiasis

Chaiyadet, S.; Tangkawattana, S.; Smout, M. J.; Ittiprasert, W.; Mann, V. H.; Deenonpoe, R.; Arunsan, P.; Loukas, A.; Brindley, P. J.; Laha, T.

10.1101/2021.12.10.472085 — cancer biology — Posted on 2022-01-05

3354 Evaluation of a predictive method for the H&E-based molecular profiling of breast cancer with deep learning

Arslan, S.; Li, X.; Schmidt, J.; Hense, J.; Geraldes, A.; Bass, C.; Brown, K.; Marcia, A.; Dewhirst, T.; Pandya, P.; Singhal, S.; Mehrotra, D.; Raharja-Liu, P.

10.1101/2022.01.04.474882 — cancer biology — Posted on 2022-01-05

3355 Single chain models illustrate the 3D RNA folding shape during translation

Guo, T.; Modi, O. L.; Hirano, J.; Guzman, H. V.; Tsuboi, T.

10.1101/2021.11.25.470027 — biophysics — Posted on 2022-01-05

3356 bMSI-CAST: a systematic method for next generation sequencing-based microsatellite instability detection in plasma cell-free DNA

Li, W.; Huang, F.; Huang, J.; YANG, J.; Zhang, H.; Zhao, L.; Xie, H.; Wang, X.; Hong, Y.; Shu, J.; Yu, J.; Li, Q.; Chen, W.; He, J.

10.1101/2021.02.22.432191 — bioinformatics — Posted on 2022-01-05

3357 Thresholding Approach for Low-Rank Correlation Matrix based on MM algorithm

Tanioka, K.; Furotani, Y.; Hiwa, S.

10.1101/2021.12.28.474401 — bioinformatics — Posted on 2022-01-06

3358 The contribution of genetic and environmental effects to Bergmanns rule and Allens rule in house mice

Ballinger, M. A.; Nachman, M. W.

10.1101/2021.06.14.448454 — evolutionary biology — Posted on 2022-01-05

3359 Function and constraint in enhancers with multiple evolutionary origins

Fong, S. L.; Capra, J. A.

10.1101/2022.01.05.475150 — evolutionary biology — Posted on 2022-01-06

3360 Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of amidbrain GABAergic neuron subtype with characteristics of REM sleep regulatory neurons

Kirjavainen, A.; Singh, P.; Lahti, L.; Seja, P.; Lelkes, Z.; Makkonen, A.; Kilpinen, S.; Ono, Y.; Salminen, M.; Aitta-Aho, T.; Stenberg, T.; Molchanova, S.; Achim, K.; Partanen, J.

10.1101/2022.01.05.473755 — developmental biology — Posted on 2022-01-06

3361 A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

Van Winkle, J. A.; Peterson, S. T.; Kennedy, E. A.; Wheadon, M. J.; Ingle, H.; Desai, C.; Rodgers, R.; Constant, D. A.; Wright, A. P.; Li, L.; Artyomov, M.; Lee, S.; Baldridge, M. T.; Nice, T. J.

10.1101/2021.06.02.446828 — immunology — Posted on 2022-01-05

3362 Transcriptional and cell type profiles of cortical brain regions showing ultradian cortisol rhythm dependent responses to emotional face stimulation

Habets, P. C.; Kalafatakis, K.; Dzyubachyk, O.; van der Werff, S.; Keo, A.; Thakrar, J.; Mahfouz, A.; Pereira, A.; Russell, G.; Lightman, S.; Meijer, O. C.

10.1101/2022.01.05.475032 — neuroscience — Posted on 2022-01-05

3363 Non-canonical odor coding in the mosquito

Younger, M. A.; Herre, M.; Goldman, O. V.; Lu, T.-C.; Caballero-Vidal, G.; Qi, Y.; Gilbert, Z. N.; Gong, Z.; Morita, T.; Rahiel, S.; Ghaninia, M.; Matthews, B. J.; Ignell, R.; Li, H.; Vosshall, L. B.

10.1101/2020.11.07.368720 — neuroscience — Posted on 2022-01-05

3364 The neural dynamics associated with computational complexity

Franco, J. P.; Bossaerts, P.; Murawski, C.

10.1101/2022.01.05.475102 — neuroscience — Posted on 2022-01-05

3365 Classification of Pacemaker Dynamics in the Mouse Intestine by Field Potential Microimaging

Iwata, N.; Takai, C.; Mochizuki, N.; Yamauchi, M.; Kaji, N.; Kasahara, Y.; Nakayama, S.

10.1101/2021.05.29.446256 — physiology — Posted on 2022-01-05

3366 Phase tracking algorithms detect both real and imaginary components of outer hair cell nonlinear membrane capacitance that exhibits dielectric loss.

Santos-Sacchi, J.

10.1101/2022.01.01.474702 — biophysics — Posted on 2022-01-05

3367 Sensing Local Field Potentials with a Directional and Scalable Depth Electrode Array

Abrego, A. M.; Khan, W.; Wright, C. E.; Islam, M. R.; Bai, X.; Ghajar, M. H.; Tandon, N.; Seymour, J.

10.1101/2021.09.20.460996 — bioengineering — Posted on 2022-01-05

3368 Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.

Papaioannou, A.; Centonze, F. G.; Metais, A.; Maurel, M.; Negroni, L.; Gonzales-Quiroz, M.; Zare Golchesmeh, E.; Blondel, A.; Koong, A. C.; Hetz, C.; Pedeux, R.; Tremblay, M. L.; Mahdizadeh, S. J.; Svensson, G.; Eriksson, L. A.; chevet, e.

10.1101/2020.03.02.972950 — biochemistry — Posted on 2022-01-05

3369 Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia

Lyu, A.; Nam, S. H.; Humphrey, R. S.; Durham, T. A.; Hu, Z.; Arasappan, D.; Horton, T. M.; Ehrlich, L. I. R.

10.1101/2022.01.05.475106 — cancer biology — Posted on 2022-01-05

3370 Nanometer-Resolution Long-term Tracking of Single Cargos Reveals Dynein Motor Mechanisms

Peng, C. S.; Zhang, Y.; Liu, Q.; Marti, G. E.; Huang, Y.-W. A.; Sudhof, T. C.; Cui, B.; Chu, S.

10.1101/2022.01.05.475120 — biophysics — Posted on 2022-01-05

3371 Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-PRC1 axis

Wang, D.; Tanaka-Yano, M.; Meader, E.; Kinney, M.; Morris, V.; Lummertz da Rocha, E.; Orkin, S.; North, T.; Daley, G. Q.; Rowe, G.

10.1101/2022.01.05.474696 — developmental biology — Posted on 2022-01-05

3372 Cardiomyocyte differentiation from iPS cells is delayed following knockout of Bcl-2

Vervliet, T.; Duelen, R.; Roderick, l. H.; Sampaolesi, M.

10.1101/2022.01.05.475068 — developmental biology — Posted on 2022-01-05

3373 Conserved meiotic mechanisms in the cnidarian Clytia hemisphaerica revealed by Spo11 knockout

Munro, C.; Cadis, H.; Houliston, E.; Huynh, J.-R.

10.1101/2022.01.05.475076 — developmental biology — Posted on 2022-01-05

3374 Full Spectrum Flow Cytometry for High-Dimensional Immunophenotyping of Murine Innate Lymphoid Cells

Mincham, K. T.; Snelgrove, R. J.

10.1101/2022.01.05.475054 — cell biology — Posted on 2022-01-05

3375 Nucleoplasmic Lamin C Rapidly Accumulates at Sites of Nuclear Envelope Rupture with BAF and cGAS

Kono, Y.; Adam, S. A.; Reddy, K.; Zheng, Y.; Medalia, O.; Goldman, R. D.; Kimura, H.; Shimi, T.

10.1101/2022.01.05.475028 — cell biology — Posted on 2022-01-05

3376 The role of collegiality in academic review, promotion, and tenure

Dawson, D.; Morales, E.; McKiernan, E. C.; Schimanski, L. A.; Niles, M. T.; Alperin, J. P.

10.1101/2022.01.05.475103 — scientific communication and education — Posted on 2022-01-05

3377 Limited consequences for loss of RNA-directed DNA methylation in Setaria viridis domains rearranged methyltransferase (DRM) mutants

Read, A. C.; Weiss, T.; Crisp, P. A.; Liang, Z.; Noshay, J.; Menard, C. C.; Wang, C.; Song, M.; Hirsch, C. N.; Springer, N. M.; Zhang, F.

10.1101/2022.01.05.474142 — plant biology — Posted on 2022-01-05

3378 Mutant KRAS-associated proteome is mainly controlled by exogenous factors

Dias Carvalho, P.; Martins, F.; Carvalho, J.; Oliveira, M. J.; Velho, S.

10.1101/2022.01.05.475056 — cancer biology — Posted on 2022-01-05

3379 Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Hoelting, T. L. B.; Cidre-Aranaz, F.; Matzek, D.; Popper, B.; Jacobi, S. J.; Li, J.; Piseddu, I.; Cadilha, B. L.; Ledderose, S.; Zwilling, J.; Ohmura, S.; Anz, D.; Kuenkele, A.; Klauschen, F.; Gruenewald, T. G. P.; Knott, M. M. L.

10.1101/2022.01.05.475061 — cancer biology — Posted on 2022-01-05

3380 Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity

Heo, Y.; Yoon, E.; Jeon, Y.-E.; Yun, J.-H.; Ishimoto, N.; Woo, H.; Park, S.-Y.; Song, J.-J.; Lee, W.

10.1101/2022.01.05.474995 — biophysics — Posted on 2022-01-05

3381 Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations

Chandrasekaran, S. N.; Cimini, B. A.; Goodale, A.; Miller, L.; Kost-Alimova, M.; Jamali, N.; Doench, J. G.; Fritchman, B.; Skepner, A.; Melanson, M.; Arevalo, J.; Caicedo, J. C.; Kuhn, D.; Hernandez, D.; Berstler, J.; Abbasi, H. S.; Root, D. E.; Swalley, S. E.; Singh, S.; Carpenter, A. E.

10.1101/2022.01.05.475090 — bioinformatics — Posted on 2022-01-05

3382 Intracellular copper storage and delivery in a bacterium

Dennison, C.; Lee, J.

10.1101/2022.01.05.475036 — biochemistry — Posted on 2022-01-05

3383 In vitro characterization of the full-length human dynein-1 cargo adaptor BicD2

Fagiewicz, R.; Crucifix, C.; Deville, C.; Kieffer, B.; Nomine, Y.; Busselez, J.; Rossolillo, P.; Schmidt, H.

10.1101/2022.01.05.474964 — biochemistry — Posted on 2022-01-05

3384 Discovery of novel compounds as potent activators of Sirt3

Reverdy, C.; Gitton, G.; Guan, X.; Adhya, I.; Dumpati, R.; Roy, S.; Errasti, G.; Delacroix, T.; Chakrabarti, R.

10.1101/2022.01.05.475007 — biochemistry — Posted on 2022-01-05

3385 Insights into I-motif stabilization by high resolution primer extension assays: Its strengths and limitations

Jamroskovic, J.; Deiana, M.; Sabouri, N.

10.1101/2022.01.05.475026 — biochemistry — Posted on 2022-01-05

3386 The genomic basis of host and vector specificity in non-pathogenic trypanosomatids

Oldrieve, G.; Malacart, B.; Lopez-Vidal, J.; Matthews, K.

10.1101/2022.01.05.475049 — genomics — Posted on 2022-01-05

3387 Simultaneous inference of parental admixture proportions and admixture times from unphased local ancestry calls

Avadhanam, S.; Williams, A. L.

10.1101/2022.01.05.475139 — genetics — Posted on 2022-01-05

3388 GJA1-20k, an internally translated isoform of Connexin 43, is an actin capping protein

Shaw, R. M.; Baum, R.; Palatinus, J. A.; Waghalter, M.; Shimura, D.; Jin, Q.; Kuzmanovich, L.; Xiao, S.; Kleber, A. G.; grintsevich, e.; Hong, T.

10.1101/2022.01.05.475034 — cell biology — Posted on 2022-01-05

3389 The formation of a fuzzy complex in the negative arm regulates the robustness of the circadian clock.

Jankowski, M. S.; Griffith, D.; Shastry, D. G.; Pelham, J. F.; Ginell, G. M.; Thomas, J.; Karande, P.; Holehouse, A. S.; Hurley, J. M.

10.1101/2022.01.04.474980 — molecular biology — Posted on 2022-01-05

3390 Intestinal Bacteroides Modulates Systemic Inflammation and the Microbial Ecology in a Mouse Model of CF: Evidence for Propionate and other Short Chain Fatty Acids Reducing Systemic Inflammatory Cytokines

Price, C.; Valls, R.; Ramsey, A.; Loeven, N.; Jones, J.; Barrack, K.; Schwartzman, J.; Royce, D.; Cramer, R. A.; Madan, J.; Ross, B.; Bliska, J. B.; O'Toole, G.

10.1101/2022.01.05.475125 — microbiology — Posted on 2022-01-05

3391 Staphylococcus aureus activates the Aryl Hydrocarbon Receptor in Human Keratinocytes

Stange, E.-L.; Rademacher, F.; Drerup, K. A.; Heinemann, N.; Möbus, L.; Gläser, R.; Harder, J.

10.1101/2022.01.05.475099 — immunology — Posted on 2022-01-05

3392 Sleep slow-wave oscillations trigger seizures in a genetic epilepsy model of Dravet syndrome

Catron, M. A.; Howe, R. K.; Besing, G.-L. K.; St. John, E. K.; Potesta, C. V.; Gallagher, M. J.; Macdonald, R. L.; Zhou, C.

10.1101/2022.01.04.474940 — neuroscience — Posted on 2022-01-05

3393 Resting-State Network Analysis of Suicide Attempt History in the UK Biobank

Thompson, M. F.; Ghahramanlou-Holloway, M.; Murphy, M. A.; Perera, K. U.; Benca-Bachman, C.; Palmer, R. H. C.; Gray, J. C.

10.1101/2022.01.04.474947 — neuroscience — Posted on 2022-01-05

3394 Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

Reed, B. D.; Meyer, M. J.; Abramzon, V.; Ad, O.; Adcock, P.; Ahmad, F. R.; Alppay, G.; Ball, J. A.; Beach, J.; Belhachemi, D.; Bellofiore, A.; Bellow, M.; Felipe Beltran, J.; Betta, A.; Wadud Bhuiya, M.; Blacklock, K.; Boer, R.; Boisvert, D.; Brault, N. D.; Buxbaum, A.; Caprio, S.; Choi, C.; Christian, T. D.; Clancy, R.; Clark, J.; Connolly, T.; Fink Croce, K.; Cullen, R.; Davey, M.; Davidson, J.; Elshenawy, M. M.; Ferrigno, M.; Frier, D.; Gudipati, S.; Hamill, S.; He, Z.; Hosali, S.; Huang, H.; Huang, L.; Kabiri, A.; Kriger, G.; Lathrop, B.; Li, A.; Lim, P.; Liu, S.; Luo, F.; Lv, C.; Ma, X.;

10.1101/2022.01.04.475002 — biophysics — Posted on 2022-01-05

3395 Front propagation and arrival times in networks with application to neurodegenerative diseases

Putra, P. S.; Oliveri, H.; Thompson, T. B.; Goriely, A.

10.1101/2022.01.04.474911 — biophysics — Posted on 2022-01-05

3396 The Metaxin Mitochondrial Import Proteins: Multiple Metaxin-like Proteins in Fungi

Adolph, K. W.

10.1101/2022.01.04.474931 — evolutionary biology — Posted on 2022-01-05

3397 Increased opposite sex association is linked with fitness benefits, otherwise sociality is subject to stabilising selection in a wild passerine

Dunning, J.; Burke, T.; Chan, A. H. H.; Chik, H. Y. J.; Evans, T.; Schroeder, J.

10.1101/2022.01.04.474937 — evolutionary biology — Posted on 2022-01-05

3398 Deterministic approximation for population dynamics in the presence of advantageous mutants

Rodriguez-Brenes, I.; Wodarz, D.; Komarova, N.

10.1101/2022.01.04.474956 — evolutionary biology — Posted on 2022-01-05

3399 Isolated Grauer's gorilla populations differ in diet and gut microbiome

Michel, A.; Minocher, R.; Niehoff, P.; Li, Y.; Nota, K.; Gadhvi, M. A.; Su, J.; Iyer, N.; Porter, A.; Ngobobo-As-Ibungu, U.; Binyinyi, E.; Pekeyake, R. N.; Parducci, L.; Caillaud, D.; Guschanski, K.

10.1101/2022.01.04.474987 — ecology — Posted on 2022-01-05

3400 Towards transboundary networks of climate-smart marine reserves in the Southern California Bight

Arafeh-Dalmau, N.; Munguia-Vega, A.; Micheli, F.; Vilalta-Navas, A.; Villasenor-Derbez, J. C.; Precoma-de la Mora, M.; Schoeman, D. S.; Medellin-Ortiz, A.; Cavanaugh, K. C.; Sosa-Nishizaki, O.; Burnham, T. L. U.; Knight, C. J.; Woodson, C. B.; Abas, M.; Abadia-Cardoso, A.; Aburto-Oropeza, O.; Esgro, M. W.; Espinosa-Andrade, N.; Beas-Luna, R.; Cardenas, N.; Carr, M. H.; Dale, K. E.; Cisneros-Soberanis, F.; Flores-Morales, A. L.; Fulton, S.; Garcia-Rodriguez, E.; Giron-Nava, A.; Gleason, M. G.; Green, A. L.; Hernandez-Velasco, A.; Ibarra-Macias, B.; Johnson, A. F.; Lorda, J.; Malpica-Cruz, L.; M

10.1101/2022.01.04.475006 — ecology — Posted on 2022-01-05

3401 B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening by pioneering factors

Kaemena, D. F.; Yoshihara, M.; Ashmore, J.; Beniazza, M.; Zhao, S.; Bertenstam, M.; Olariu, V.; Katayama, S.; Okita, K.; Tomlinson, S.; Yusa, K.; Kaji, K.

10.1101/2022.01.04.474927 — cell biology — Posted on 2022-01-05

3402 Structural basis of peptidomimetic agonism revealed by small molecule GLP-1R agonists Boc5 and WB4-24

Cong, Z.; Zhou, Q.; Li, Y.; Chen, L.-N.; Zhang, Z.-C.; Liang, A.; Liu, Q.; Wu, X.; Dai, A.; Xia, T.; Wu, W.; Zhang, Y.; Yang, D.; Wang, M.-W.

10.1101/2022.01.05.475023 — molecular biology — Posted on 2022-01-05

3403 A Novel Virus Discovered in the Yeast Pichia membranifaciens.

Lee, M. D.; Creagh, J. W.; Fredericks, L. R.; Crabtree, A. M.; Patel, J. S.; Rowley, P. A.

10.1101/2022.01.05.475065 — molecular biology — Posted on 2022-01-05

3404 RNA-mediated nucleosome depletion is required for elimination of transposon-derived DNA.

Singh, A.; Maurer-Alcala, X. X.; Solberg, T.; Gisler, S.; Ignarski, M.; Swart, E. C.; Nowacki, M.

10.1101/2022.01.04.474918 — molecular biology — Posted on 2022-01-05

3405 Signaling modality within gp130 receptor enhances tissue regeneration

Shkhyan, R.; Flynn, C.; Lamoure, E.; Van Handel, B.; Sarkar, A.; Lu, J.; York, J.; Banks, N.; Van der Horst, R.; Liu, N.; Lee, S.; Bajaj, P.; Vadivel, K.; Harn, H. I.-C.; Lozito, T.; Lieberman, J.; Chuong, C.-M.; Hurtig, M.; Evseenko, D.

10.1101/2022.01.05.475124 — molecular biology — Posted on 2022-01-05

3406 Mapping functional regions of essential bacterial proteins with dominant-negative protein fragments

Savinov, A.; Fernandez, A.; Fields, S.

10.1101/2022.01.04.474984 — microbiology — Posted on 2022-01-05

3407 Genomic dissection of the microevolution of Australian epidemic Bordetella pertussis

XU, Z.; Hu, D.; Luu, L. D. W.; Octavia, S.; Keil, A. D.; Sintchenko, V.; Tanaka, M. M.; Mooi, F. R.; Robson, J.; Lan, R.

10.1101/2022.01.05.475016 — microbiology — Posted on 2022-01-05

3408 Herpes simplex virus 1 expressing GFP-tagged virion host shutoff (vhs) protein uncouples the activities of degradation and nuclear retention of the infected cell transcriptome

Wise, E. L.; Samolej, J.; Elliott, G.

10.1101/2022.01.04.475014 — microbiology — Posted on 2022-01-05

3409 Recurrent emergence of carbapenem resistance in Klebsiella pneumoniae mediated by an inhibitory ompK36 mRNA secondary structure

Wong, J. L. C.; David, S.; Sanchez-Garrido, J.; Woo, J. Z.; Low, W. W.; Morecchiato, F.; Giani, T.; Rossolini, G. M.; Brett, S. J.; Clements, A.; Aanensen, D. M.; Rouskin, S.; Frankel, G.

10.1101/2022.01.05.475072 — microbiology — Posted on 2022-01-05

3410 Identification and molecular characterization of novel viruses in Ugandan cattle

Balinandi, S.; Hayer, J.; Cholleti, H.; Lutwama, J.; Wille, M.; Malmberg, M.; Mugisha, L.

10.1101/2022.01.05.475030 — microbiology — Posted on 2022-01-05

3411 Combination therapy of metformin with sodium selenite reverses effects of monotherapy on nitric oxide production, IL-1β and TNF-α release, and upregulates relative expression of Bcl-2 by LPS-activated human primary monocytes in T-cell acute lymphoblastic leukemia

Rostane, F.; Sari, N.; Bali, I.; Messali, R.; Hadjidj, Z.; Miliani, M.; Belhassena, I.; El Mezouar, C.; Aribi, M.

10.1101/2022.01.04.475000 — immunology — Posted on 2022-01-05

3412 Drosophila Mechanical Nociceptors Preferentially Sense Localized Poking

Liu, Z.; Wang, Q.-X.; Wu, M.-H.; Lin, S.-Z.; Feng, X.-X.; Li, B.; Liang, X.

10.1101/2022.01.04.474910 — neuroscience — Posted on 2022-01-05

3413 Elixirs of Life, threats to Human and Environmental Well-being: Assessment of Antibiotic Residues in Raw Meat Sold Within Central Market Kaduna Metropolis, Kaduna State, Nigeria

Habeeb, L. M.; Olaniyi, O. A.; Yusu, A. B.; Azaman, I.; Raimi, M. O.

10.1101/2022.01.04.474997 — pharmacology and toxicology — Posted on 2022-01-05

3414 Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome

Yoon, J.-Y.; Daneshgar, N.; Chu, Y.; Chen, B.; Hefti, M.; Irani, K.; Song, L.-S.; Brenner, C.; Abel, E. D.; London, B.; Dai, D.-F.

10.1101/2022.01.04.475008 — pathology — Posted on 2022-01-05

3415 Single-cell multi-omics analyses reveal EZH2 as a main driver of retinoic acid resistance in PLZF-RARA leukemia.

Poplineau, M.; Platet, N.; Mazuel, A.; Herault, L.; Koide, S.; Kuribayashi, W.; Carbuccia, N.; N'Guyen, L.; Vernerey, J.; Oshima, M.; Birnbaum, D.; Iwama, A.; Duprez, E.

10.1101/2022.01.04.474890 — cancer biology — Posted on 2022-01-05

3416 Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia

Zhai, Y.; Singh, P.; Dolnik, A.; Brazda, P.; Atlasy, N.; del Gaudio, N.; Dohner, K.; Dohner, H.; Minucci, S.; Martens, J.; Altucci, L.; Megchelenbrink, W.; Bullinger, L.; Stunnenberg, H. G.

10.1101/2022.01.04.474929 — cancer biology — Posted on 2022-01-05

3417 PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides

Saillard, C.; Delecourt, F.; Schmauch, B.; Moindrot, O.; Svrcek, M.; Bardier-Dupas, A.; Emile, J.-F.; Ayadi, M.; Rebours, V.; de Mestier, L.; Hammel, P.; Neuzillet, C.; Bachet, J.-B.; Iovanna, J.; Dusetti, N.; Blum, Y.; Richard, M.; Kermezli, Y.; Paradis, V.; Zaslavskiy, M.; Courtiol, P.; Kamoun, A.; Nicolle, R.; Cros, J.

10.1101/2022.01.04.474951 — cancer biology — Posted on 2022-01-05

3418 EchinoDB: An update to the web-based application for genomic and transcriptomic data on Echinoderms.

Mittal, V.; Reid, R. W.; Jacob Machado, D.; Mashanov, V.; Janies, D. A.

10.1101/2022.01.03.474134 — bioinformatics — Posted on 2022-01-05

3419 ABRIDGE: An ultra-compression software for SAM alignment files

Banerjee, S.; Andorf, C.

10.1101/2022.01.04.474935 — bioinformatics — Posted on 2022-01-05

3420 Engineered collagen-targeting therapeutics reverse lung and kidney fibrosis in mice

WHITE, M. J. V.; Raczy, M.; Budina, E.; Solanki, A.; Zhang, Z. J.; Gray, L. T.; Cao, S.; Alpar, A. T.; Hubbell, J.

10.1101/2022.01.04.474747 — bioengineering — Posted on 2022-01-05

3421 Investigating the NRAS 5' UTR as a Target for Small Molecules

Balaratnam, S.; Torrey, Z. R.; Calabrese, D. R.; Banco, M. T.; Yazdani, K.; Liang, X.; Ferre-D'Amare, A.; Incarnato, D.; Schneekloth, J. S.

10.1101/2022.01.05.475055 — biochemistry — Posted on 2022-01-05

3422 Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

Perveen, S.; Zepeda-Velazquez, C. A.; McLeod, D.; Marcellus, R.; Mohammed, M.; Abbey, M.; Ensan, D.; Panagopoulos, D.; Trush, V.; Gibson, E.; Dong, A.; Halabelian, L.; Poda, G.; Owen, J.; Aman, A.; Kiyota, T.; Mamai, A.; Arrowsmith, C. H.; Brown, P. J.; Schapira, M.; Al-awar, R.; Vedadi, M.

10.1101/2022.01.05.475077 — biochemistry — Posted on 2022-01-05

3423 Biochemical characterization of actin assembly mechanisms with ALS-associated profilin variants

Liu, X.; Pimm, M. L.; Haarer, B.; Brawner, A. T.; Henty-Ridilla, J. L.

10.1101/2022.01.05.475096 — biochemistry — Posted on 2022-01-05

3424 Molecular Mechanism of Hyperactivation Conferred by a Truncated TRPA1 Disease Mutant Suggests New Gating Insights

Bali, A.; Schaefer, S. P.; Trier, I.; Zhang, A. L.; Kabeche, L.; Paulsen, C. E.

10.1101/2022.01.05.475133 — biochemistry — Posted on 2022-01-05

3425 Automated Landmarking via Multiple Templates

Zhang, C.; Porto, A.; Rolfe, S.; Kocatulum, A.; Maga, A. M.

10.1101/2022.01.04.474967 — evolutionary biology — Posted on 2022-01-05

3426 Comparative whole plastome and low copy number phylogenetics of the core Saccharinae and Sorghinae.

Lloyd Evans, D.; Hughes, B.; Joshi, S. V.

10.1101/2022.01.04.474895 — evolutionary biology — Posted on 2022-01-05

3427 Recurrent co-option and recombination of cytokine and three finger proteins in multiple reproductive tissues throughout salamander evolution

Wilburn, D. B.; Kunkel, C. L.; Feldhoff, R. C.; Feldhoff, P. W.; Searle, B. C.

10.1101/2022.01.04.475003 — evolutionary biology — Posted on 2022-01-05

3428 The bounded coalescent model: conditioning a genealogy on a minimum root date

Carson, J.; Ledda, A.; Ferretti, L.; Keeling, M.; Didelot, X.

10.1101/2022.01.04.474909 — evolutionary biology — Posted on 2022-01-05

3429 Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

Zhen, H.; Xu, L.; Cai, C.; Zhou, Y.; Liu, J.; Zhu, Z.; Kang, W.; Chen, D.; Pei, S.; Xue, T.; Cen, W.; Shi, C.; Wu, X.; Huang, Y.; Xu, C.; Yan, Y.; Yang, Y.; He, W.; Hu, X.; Zhang, Y.; Chen, Y.; Bi, C.; He, C.; Xue, L.; Xiao, S.; Yue, Z.; Jiang, Y.; Yu, J.-K.; Jarvis, E.; Li, G.; Lin, G.; Zhang, Q.; Zhou, Q.

10.1101/2022.01.04.475009 — evolutionary biology — Posted on 2022-01-05

3430 Evidences for newer insecticides and growth regulators resistance in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) in Karnataka, India

Ballari, H. S.; Udikeri, S. S.; Kalia, V.

10.1101/2022.01.02.474718 — ecology — Posted on 2022-01-05

3431 Spatially unique Shh-Fgf8 distribution in regenerating limb guarantees consistent limb morphogenesis in different limb sizes and contributes to axolotl specific digit patterning.

furukawa, s.; yamamoto, s.; kashimoto, r.; morishita, y.; Satoh, A.

10.1101/2022.01.04.475010 — developmental biology — Posted on 2022-01-05

3432 Oligomerization of peripheral membrane proteins provides tunable control of cell surface polarity

Lang, C. F.; Munro, E.

10.1101/2022.01.04.474999 — cell biology — Posted on 2022-01-05

3433 Mandatory coupling of zygotic transcription to DNA replication in early Drosophila embryos

Cho, C.-Y.; Kemp, J. P.; Duronio, R. J.; O'Farrell, P. H.

10.1101/2022.01.04.474810 — cell biology — Posted on 2022-01-05

3434 A unique class of Zn2+-binding PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

Sacco, M. D.; Wang, S.; Adapa, S. R.; Zhang, X.; Gongora, M. V.; Gatdula, J. R.; Lewandowski, E. M.; Hammond, L. R.; Townsend, J. A.; Marty, M. T.; Wang, J.; Eswara, P. J.; Jiang, R. H. Y.; Sun, X.; Chen, Y.

10.1101/2022.01.04.474981 — microbiology — Posted on 2022-01-05

3435 Presence of sodium taurocholate co-transporting polypeptide and Hepatitis B replication marker on placenta: Another home for the virus

Garg, G.; MN, M.; Patel, K.; Purwar, S.; Mukhopadhyay, S.; Mishra, N.; Gupta, S.; Rawat, S. K.; Khosla, R.; Singh, J.; Nema, S.; Biswas, D.; Singh, A. K.; Vyas, A. K.

10.1101/2022.01.05.475013 — microbiology — Posted on 2022-01-05

3436 Genomic insights into the phylogeny and biomass-degrading enzymes of rumen ciliates

Li, Z.; Wang, X.; Zhang, Y.; Yu, Z.; Zhang, T.; Dai, X.; Pan, X.; Jing, R.; Yan, Y.; Liu, Y.; Gao, S.; Li, F.; Huang, Y.; Tian, J.; Yao, J.; Xing, X.; Shi, T.; Ning, J.; Yao, B.; Huang, H.; Jiang, Y.

10.1101/2022.01.05.474053 — microbiology — Posted on 2022-01-05

3437 Interferon lambda signals in maternal tissues to exert protective and pathologic effects in a gestational-stage dependent manner

Casazza, R. L.; Philip, D. T.; Lazear, H. M.

10.1101/2022.01.04.475019 — immunology — Posted on 2022-01-05

3438 Texture-like representation of objects in human visual cortex

Jagadeesh, A. V.; Gardner, J.

10.1101/2022.01.04.474849 — neuroscience — Posted on 2022-01-05

3439 Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in In Vitro, In Vivo and Ex Vivo Models of Pulmonary Fibrosis

Ahangari, F.; Becker, C.; Foster, D. G.; Chioccioli, M.; Nelson, M.; Beke, K.; wang, X.; Readhead, B.; Meador, C.; Correll, K.; Lili, L.; Roybal, H. M.; Rose, K.-A.; Ding, S.; Barnthaler, T.; Briones, N.; Deluliis, G.; Schupp, J. C.; Li, Q.; Omote, N.; Aschner, Y.; Kopf, K. W.; Magnusson, B.; Hicks, R.; Backmark, A.; Cousens, L. P.; Dudley, J. T.; Kaminski, N.; Downey, G. P.

10.1101/2022.01.04.474955 — systems biology — Posted on 2022-01-05

3440 A Wake-Up Call: Determination of Antibiotics Residue Level in Raw Meat in Abattoir and Selected Slaughterhouses in Five Local Government in Kano State, Nigeria.

Habeeb, L. M.; Olaniyi, O. A.; Garba, M.; Raimi, M. O.

10.1101/2022.01.04.474991 — pharmacology and toxicology — Posted on 2022-01-05

3441 Evaluation of a predictive method for the H&E-based molecular profiling of breast cancer with deep learning

Raharja-Liu, P.; Arslan, S.; Li, X.; Schmidt, J.; Hense, J.; Geraldes, A.; Bass, C.; Brown, K.; Marcia, A.; Dewhirst, T.; Pandya, P.; Singhal, S.; Mehrotra, D.

10.1101/2022.01.04.474882 — cancer biology — Posted on 2022-01-05

3442 HMGN5 escorts oncogenic STAT3 signaling by regulating chromatin landscape in tumorigenesis of breast cancer

Mou, J.; Huang, M.; Wang, F.; Xu, X.; Xie, H.; Lu, H.; Li, M.; Li, Y.; Kong, W.; Chen, J.; Xiao, Y.; Chen, Y.; Wang, C.; Ren, J.

10.1101/2022.01.04.474868 — cancer biology — Posted on 2022-01-05

3443 Autophagy and evasion of immune system by SARS-CoV-2. Structural features of the Non-structural protein 6 from Wild Type and Omicron viral strains interacting with a model lipid bilayer.

Bignon, E.; Marazzi, M.; Grandemange, S.; Monari, A.

10.1101/2022.01.05.475107 — biophysics — Posted on 2022-01-05

3444 Theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces

Sadhu, R. K.; Barger, S. R.; Penic, S.; Iglic, A.; Krendel, M.; Gauthier, N.; Gov, N.

10.1101/2022.01.04.474893 — biophysics — Posted on 2022-01-05

3445 SPITFIR(e): A supermaneuverable algorithm for restoring 2D-3D fluorescence images and videos,and background subtraction

Prigent, S.; Nguyen, H.-N.; Leconte, L.; Valades-Cruz, C. A.; Hajj, B.; Salamero, J.; Kervrann, C.

10.1101/2022.01.04.474883 — bioinformatics — Posted on 2022-01-05

3446 PDBspheres - a method for finding 3D similarities in local regions in proteins

Zemla, A.; Allen, J. E.; Kirshner, D.; Lightstone, F. C.

10.1101/2022.01.04.474934 — bioinformatics — Posted on 2022-01-05

3447 Unraveling membrane properties at the organelle-level with LipidDyn

Scrima, S.; Tiberti, M.; Campo, A.; Corcelle-Termeau, E.; Judith, D.; Moller Foged, M.; Bundgaard Clemmens, K. K.; Tooze, S.; Jäättelä, M.; Maeda, K.; Lambrughi, M.; Papaleo, E.

10.1101/2022.01.04.474788 — bioinformatics — Posted on 2022-01-05

3448 Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

Santos, L. H.; Kronenberger, T.; Almeida, R. G.; Barbosa da Silva, E.; Rocha, R. E. O.; Oliveira, J. C.; Barreto, L. V.; Skinner, D.; Fajtova, P.; Giardini, M. A.; Woodworth, B.; Bardine, C.; Lourenco, A. L.; Craik, C. S.; Poso, A.; Podust, L. M.; McKerrow, J. H.; Siqueira-Neto, J. L.; O'Donoghue, A. J.; da Silva Junior, E. N.; Ferreira, R.

10.1101/2022.01.05.475095 — biochemistry — Posted on 2022-01-05

3449 Differential mosquito attraction to humans is associated with skin-derived carboxylic acid levels

De Obaldia, M. E.; Morita, T.; Dedmon, L. C.; Boehmler, D. J.; Jiang, C. S.; Zeledon, E. V.; Cross, J. R.; Vosshall, L. B.

10.1101/2022.01.05.475088 — neuroscience — Posted on 2022-01-05

3450 Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning

Daniels, K. G.; Wang, S.; Simic, M. S.; Bhargava, H. K.; Capponi, S.; Tonai, Y.; Yu, W.; Bianco, S.; Lim, W. A.

10.1101/2022.01.04.474985 — synthetic biology — Posted on 2022-01-05

3451 DNA methylation signatures of duplicate gene evolution in angiosperms

Kenchanmane Raju, S. K.; Ledford, S. M.; Niederhuth, C. E.

10.1101/2020.08.31.275362 — plant biology — Posted on 2022-01-05

3452 Task-independent metrics of computational hardness predict human cognitive performance

Franco, J. P.; Doroc, K.; Yadav, N.; Bossaerts, P.; Murawski, C.

10.1101/2021.04.25.441300 — animal behavior and cognition — Posted on 2022-01-05

3453 Predictive Modeling of Pseudomonas syringae Virulence on Bean using Gradient Boosted Decision Trees

Almeida, R. N. D.; Greenberg, M.; Bundalovic-Torma, C.; Martel, A.; Wang, P. W.; Middleton, M.; Chatterton, S.; Desveaux, D.; Guttman, D. S.

10.1101/2021.05.27.445966 — genomics — Posted on 2022-01-05

3454 SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

Walter, M.; Chen, I. P.; Vallejo-Gracia, A.; Kim, I.-J.; Bielska, O.; Lam, V. L.; Hayashi, J. M.; Cruz, A.; Shah, S.; Gross, J. D.; Krogan, N. J.; Schilling, B.; Ott, M.; Verdin, E.

10.1101/2022.01.04.474979 — microbiology — Posted on 2022-01-05

3455 SARS-CoV-2 Infection of Microglia Elicits Pro-inflammatory Activation and Apoptotic Cell Death

Jeong, G. U.; Lyu, J.; Kim, K.-D.; Chung, Y. C.; Yoon, G. Y.; Lee, S.; Hwang, I.; Shin, W.-H.; Ko, J.; Lee, J.-Y.; Kwon, Y.-C.

10.1101/2022.01.04.475015 — microbiology — Posted on 2022-01-05

3456 Myofibroblast differentiation is governed by adhesion mechanics, and inhibition of the stress sensor Talin2 reverses lung fibrosis

WHITE, M. J. V.; Ozkan, M.; Medellin, J. E. G.; Solanki, A.; Hubbell, J.

10.1101/2021.06.07.447403 — immunology — Posted on 2022-01-05

3457 Virtually the same? Evaluating the effectiveness of remote undergraduate research experiences

Hess, R. A.; Erickson, O. A.; Cole, R. B.; Isaacs, J. M.; Alvarez-Clare, S.; Arnold, J.; Augustus-Wallace, A. C.; Ayoob, J. C.; Berkowitz, A.; Branchaw, J. L.; Burgio, K. R.; Cannon, C. H.; Ceballos, R. M.; Cohen, C. S.; Coller, H.; Disney, J.; Doze, V. A.; Eggers, M. J.; Ferguson, E. L.; Gray, J. J.; Greenberg, J. T.; Hoffmann, A.; Jensen-Ryan, D.; Kao, R. M.; Keene, A. C.; Kowalko, J.; Lopez, S. A.; Mathis, C.; Minkara, M.; Murren, C. J.; Ondrechen, M. J.; Ordonez, P.; Osano, A.; Padilla-Crespo, E.; Palchoudhury, S.; Qin, H.; Ramirez-Lugo, J.; Reithel, J.; Shaw, C. A.; Smith, A.; Smith, R. J

10.1101/2022.01.03.474815 — scientific communication and education — Posted on 2022-01-05

3458 Programmed knockout mutation of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic opisthorchiasis

Chaiyadet, S.; Tangkawattana, S.; Smout, M. J.; Ittiprasert, W.; Mann, V. H.; Deenonpoe, R.; Arunsan, P.; Loukas, A.; Brindley, P. J.; Laha, T.

10.1101/2021.12.10.472085 — cancer biology — Posted on 2022-01-05

3459 Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants

Neamtu, A.; Mocci, F.; Laaksonen, A.; Barroso da Silva, F. L.

10.1101/2022.01.04.474958 — biophysics — Posted on 2022-01-05

3460 Computational study of the furin cleavage domain of SARS-CoV-2: delta binds strongest of extant variants

Jawaid, M. Z.; Baidya, A.; Jakovcevic, S.; Lusk, J.; Mahboubi-Ardakani, R.; Solomon, N.; Gonzalez, G.; Arsuaga, J.; Vazquez, M.; Davis, R. L.; Cox, D. L.

10.1101/2022.01.04.475011 — biophysics — Posted on 2022-01-05

3461 A Substrate-triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-L-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate

McBride, M. J.; Nair, M. A.; Sil, D.; Slater, J. W.; Neugebauer, M. E.; Chang, M.; Boal, A.; Krebs, C.; Bollinger, J. M.

10.1101/2021.12.02.471016 — biochemistry — Posted on 2022-01-05

3462 Genomic perspectives on the emerging SARS-CoV-2 Omicron variant

Ma, W.; Yang, J.; Fu, H.; Su, C.; Yu, C.; Wang, Q.; de Vasconcelos, A. T. R.; Bazykin, G.; Bao, Y.; Li, M.

10.1101/2022.01.05.474231 — genomics — Posted on 2022-01-05

3463 The spatial landscape of gene expression isoforms in tissue sections

Lebrigand, K.; Bergenstrahle, J.; Thrane, K.; Mollbrink, A.; Meletis, K.; Barbry, P.; Waldmann, R.; Lundeberg, J.

10.1101/2020.08.24.252296 — genomics — Posted on 2022-01-05

3464 Oct1 recruits the histone lysine demethylase Utx to canalize lineage specification

Perovanovic, J.; Wu, Y.; Shen, Z.; Hughes, E.; Chandrasekharan, M. B.; Tantin, D.

10.1101/2020.12.01.406488 — developmental biology — Posted on 2022-01-05

3465 Sequence assignment validation in cryo-EM models with checkMySequence

Chojnowski, G.

10.1101/2022.01.04.474974 — molecular biology — Posted on 2022-01-05

3466 An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

Zhou, B.; Zhou, R.; Chan, J. F.-W.; Luo, M.; Peng, Q.; Yuan, S.; Mok, B. W.-Y.; Chen, B.; Wang, P.; Poon, V. K.-M.; Chu, H.; Chan, C. C.-S.; Tsang, J. O.-L.; Chan, C. C.-Y.; Au, K.-K.; Man, H.-O.; Lu, L.; To, K. K.-W.; Chen, H.; Yuen, K.-Y.; Chen, Z.

10.1101/2022.01.05.475037 — immunology — Posted on 2022-01-05

3467 Blocking antibodies against integrin-a3, integrin-aM, and integrin-aMb2 de-differentiate myofibroblasts and reverse lung and kidney fibroses in a mouse model

WHITE, M.; ozkan, m.; Medellin, J. E. G.; Raczy, M.; Koss, K. M.; Solanki, A.; Zhang, Z. J.; Alpar, A. T.; Naved, B. A.; Wertheim, J.; Hubbell, J. A.

10.1101/2021.06.07.447405 — immunology — Posted on 2022-01-05

3468 Leveraging spiking deep neural networks to understand the neural mechanisms underlying selective attention

Soerensen, L. K. A.; Zambrano, D.; Slagter, H. A.; Bohte, S. M.; Scholte, H. S.

10.1101/2020.12.15.422863 — neuroscience — Posted on 2022-01-05

3469 The evolution of partner specificity in mutualisms

Carlson, C. I.; Akcay, E. I.; Morsky, B.

10.1101/2021.12.10.472103 — evolutionary biology — Posted on 2022-01-05

3470 Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

Wang, L.; Kainulainen, M. H.; Jiang, N.; Di, H.; Bonenfant, G.; Mills, L.; Currier, M.; Shrivastava-Ranjan, P.; Calderon, B. M.; Sheth, M.; Mann, B. R.; Hossain, J.; Lin, X.; Lester, S.; Pusch, E.; Jones, J.; Cui, D.; Chatterjee, P.; Jenks, H. M.; Morantz, E.; Larson, G.; Hatta, M.; Harcourt, J.; Tamin, A.; Lin, Y.; Tao, Y.; Zhao, K.; Lacek, K.; Burroughs, A.; Wong, T.; Tong, S.; Barnes, J. R.; Tenforde, M. W.; Self, W. H.; Shapiro, N. I.; Exline, M. C.; Files, D. C.; Gibbs, K. W.; Hager, D. N.; Patel, M.; Laufer Halpin, A. S.; McMullan, L. K.; Lee, J. S.; Xia, H.; Xie, X.; Shi, P.-Y.; Davis,

10.1101/2021.11.24.469906 — microbiology — Posted on 2022-01-05

3471 Dead infant carrying by chimpanzee mothers in the Budongo Forest

Soldati, A.; Fedurek, P.; Crockford, C.; Adue, S.; Akankwasa, J. W.; Asiimwe, C.; Asua, J.; Atayo, G.; Chandia, B.; Freymann, E.; Fryns, C.; Muhumuza, G.; Taylor, D.; Zuberbuhler, K.; Hobaiter, C.

10.1101/2021.12.22.473786 — animal behavior and cognition — Posted on 2022-01-05

3472 Investigating neurotrophin genetics and hippocampal volume

de Frutos, J.; Vacher, M.; Porter, T.; Brown, B.; Laws, S.

10.1101/2022.01.01.474700 — genetics — Posted on 2022-01-05

3473 Age differences in the functional architecture of the human brain

Setton, R.; Mwilambwe-Tshilobo, L.; Girn, M.; Lockrow, A. W.; Baracchini, G.; Hughes, C.; Lowe, A. J.; Cassidy, B. N.; Li, J.; Luh, W.-M.; Bzdok, D.; Leahy, R. M.; Ge, T.; Margulies, D. S.; Misic, B.; Bernhardt, B. C.; Stevens, W. D.; De Brigard, F.; Kundu, P.; Turner, G. R.; Spreng, R. N.

10.1101/2021.03.31.437922 — neuroscience — Posted on 2022-01-05

3474 Classification of daily crop phenology in PhenoCams using deep learning and hidden markov models

Taylor, S. D.; Browning, D. M.

10.1101/2021.10.20.465168 — plant biology — Posted on 2022-01-05

3475 Tobacco HY5, NtHY5, positively regulates flavonoid biosynthesis and enhances salt stress tolerance

Singh, D.; Singh, H.; Singh, N.; Dwivedi, S.; Trivedi, P. K.

10.1101/2022.01.05.475064 — plant biology — Posted on 2022-01-05

3476 Improved management facilitates return of an iconic fish species

MacKenzie, B. R.; Aarestrup, K.; Birnie-Gauvin, K.; Cardinale, M.; Christoffersen, M.; Lund, H. S.; Onandia, I.; Quilez-Badia, G.; Payne, M. R.; Sundelof, A.; Sorensen, C.; Casini, M.

10.1101/197780 — ecology — Posted on 2022-01-05

3477 Hypoxia-Induced Ethanol Production in Arabidopsis Root Apex Cells Affects Endocytic Vesicle Recycling and F-Actin Organisation

Kagenishi, T.; Baluska, F.; Yokawa, K.

10.1101/2022.01.05.475021 — plant biology — Posted on 2022-01-05

3478 Asymmetric wall ingrowth deposition in Arabidopsis phloem parenchyma transfer cells is tightly associated with sieve elements

Wei, X.; Huang, Y.; Collings, D. A.; McCurdy, D. W.

10.1101/2022.01.04.475004 — plant biology — Posted on 2022-01-05

3479 Cellular and gene expression patterns associated with root bifurcation in Selaginella

Fang, T.; Motte, H.; Parizot, B.; Smet, W.; Yang, X.; Walker, L.; Njo, M.; Bassel, G.; Beeckman, T.

10.1101/2022.01.03.474808 — plant biology — Posted on 2022-01-05

3480 Comparative plant transcriptome profiling of Arabidopsis and Camelina infested with Myzus persicae aphids acquiring circulative and non-circulative viruses reveals virus- and plant-specific alterations relevant to aphid feeding behavior and transmission

Chesnais, Q.; Golyaev, V.; Velt, A.; Rustenholz, C.; Brault, V.; Pooggin, M.; Drucker, M.

10.1101/2022.01.04.474350 — plant biology — Posted on 2022-01-05

3481 Shelterin components modulate nucleic acids condensation and phase separation in the context of telomeric DNA

Soranno, A.; Incicco, J. J.; De Bona, P.; Tomko, E. J.; Galburt, E.; Holehouse, A. S.; Galletto, R.

10.1101/2021.04.30.442189 — biophysics — Posted on 2022-01-05

3482 Joint dimension reduction and clustering analysis for single-cell RNA-seq and spatial transcriptomics data

Liu, W.; Liao, X.; Zhou, X.; Shi, X.; Liu, J.

10.1101/2021.12.25.474153 — genomics — Posted on 2022-01-05

3483 Plant speciation in the Namib Desert: origin of a widespread derivative species from a narrow endemic

Milton, J. J.; Affenzeller, M.; Abbott, R. J.; Comes, H.-P.

10.1101/2022.01.04.474907 — evolutionary biology — Posted on 2022-01-05

3484 PLEKHA5 regulates mitotic progression by promoting APC/C localization to microtubules

Cao, X.; Shami Shah, A.; Sanford, E. J.; Smolka, M. B.; Baskin, J. M.

10.1101/2022.01.04.474939 — cell biology — Posted on 2022-01-05

3485 Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis

Luisi, B. F.; Islam, M. S.; Hardwick, S. W.; Quell, L.; Chirgadze, D. Y.; Görke, B.

10.1101/2022.01.04.474903 — molecular biology — Posted on 2022-01-05

3486 A multiwell-plate Caenorhabditis elegans assay for assessing the therapeutic potential of Bacteriophages against Clinical Pathogens

Manohar, P.; Loh, B.; Namasivayam, E.; Loganathan, A.; Nachimuthu, R.; Leptihn, S.

10.1101/2022.01.05.474866 — microbiology — Posted on 2022-01-05

3487 ifCNV: a novel isolation-forest-based package to detect copy number variations from NGS datasets

Cabello, S.; Vendrell, J. A.; Van Goethem, C.; Brousse, M.; Goze, C.; Frantz, L.; Solassol, J.

10.1101/2022.01.03.474771 — bioinformatics — Posted on 2022-01-05

3488 Glycosylated proteins identified for the first time in the alga Euglena gracilis

O'Neill, E. C.

10.1101/2021.10.28.466288 — biochemistry — Posted on 2022-01-05

3489 Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

Cuevas-Navarro, A.; Rodriguez-Munoz, L.; Grego-Bessa, J.; Cheng, A.; Rauen, K. A.; Urisman, A.; McCormick, F.; Jimenez, G.; Castel, P.

10.1101/2022.01.04.474894 — genetics — Posted on 2022-01-05

3490 Pathogens in exacerbations of chronic rhinosinusitis differ in sensitivity to silver nanoparticles

Szaleniec, J.; Gibała, A.; Stalinska, J.; Ocwieja, M.; Zeliszewska, P.; Drukała, J.; Szaleniec, M.; Gosiewski, T.

10.1101/2022.01.03.474872 — microbiology — Posted on 2022-01-05

3491 Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

Mao, Q.; Acharya, A.; Rodriguez-delaRosa, A.; Marchiano, F.; Dehapiot, B.; Al Tanoury, Z.; Rao, J.; Diaz-Cuadros, M.; Mansur, A.; Wagner, E.; Chardes, C.; Gupta, V. A.; Lenne, P.-F.; Habermann, B. H.; Theodoly, O.; Pourquie, O.; Schnorrer, F.

10.1101/2021.10.24.465614 — developmental biology — Posted on 2022-01-05

3492 Microbial succession on degrading micropollutants under recurrent exposure

Izabel-Shen, D.; Li, S.; Luo, T.; Wang, J.; Li, Y.; Sun, Q.; Yu, C.-P.; Hu, A.

10.1101/2021.08.24.457489 — ecology — Posted on 2022-01-05

3493 Adaptive coding of stimulus information in human fronto-parietal cortex during visual classification

Wisniewski, D.; Gonzalez-Garcia, C.; Formica, S.; Woolgar, A.; Brass, M.

10.1101/2021.11.22.469511 — neuroscience — Posted on 2022-01-05

3494 Organization and dynamics of the SpoVAEa protein, and its surrounding inner membrane lipids upon germination of Bacillus subtilis spores

Wen, J.; Vischer, N. O. E.; de Vos, A. L.; Manders, E. M. M.; Setlow, P.; Brul, S.

10.1101/2021.11.20.469378 — microbiology — Posted on 2022-01-05

3495 Towards Biophysical Markers of Depression Vulnerability

Pinotsis, D.; Fitzgerald, S.; See, C.; Sementsova, A.; Widge, A. S.

10.1101/2021.12.08.471836 — neuroscience — Posted on 2022-01-05

3496 Drug-Target Binding Affinity Prediction Using Transformers

Saadat, M.; Behjati, A.; Zare-Mirakabad, F.; Gharaghani, S.

10.1101/2021.09.30.462610 — bioinformatics — Posted on 2022-01-05

3497 Isolation and Identification of taxonomically diverse bacterial endophytes from citrus in Punjab Pakistan

Atta, S.

10.1101/2022.01.04.474905 — molecular biology — Posted on 2022-01-04

3498 Cost-effectiveness of quadrivalent versus trivalent inactivated influenza vaccines for the Portuguese elderly population

Tavares, D.; Mourino, H.; Rodriguez, C. A.; Saborido, C. M.

10.1101/2022.01.04.474923 — scientific communication and education — Posted on 2022-01-04

3499 An Antioxidant Polysaccharide from Ganoderma lucidum Induces Apoptotic Activity in Breast Cancer Cell Line

Uddin Pk, M. M.; Pervin, R.; Shahangir Biswas, M.; Rahman, M.

10.1101/2022.01.04.474971 — pharmacology and toxicology — Posted on 2022-01-04

3500 Influence of sequencing depth on bacterial classification and abundance in bacterial communities

Mejia, F.; Aviles Jimenez, F.; Mendez Tenorio, A.

10.1101/2022.01.04.474922 — bioinformatics — Posted on 2022-01-04

3501 Cucumeropsis mannii seed oil (CMSO) ameliorates adipokines dysfunction and dyslipidemia in male Wistar rats exposed to Bisphenol-A

Aja, P. M.; Chukwu, D. C.; Agu, P. C.; Ani, O. G.; Ekpono, E. U.; Ogwoni, H. A.; Awoke, J. N.; Ogbu, P. N.; Aja, L.; Nwite, F. E.; Ukachu, O. U.; Orji, O. U.; Nweke, P. C.; Egwu, C. O.; Ekpono, E. U.; EWa, G. O.; Igwenyi, I. O.; Alum, E. U.; Uti, D. E.; Tusubira, D.; Offor, C. E.; Njoku, A.; Maduagwunna, E. K.

10.1101/2022.01.04.474972 — biochemistry — Posted on 2022-01-04

3502 The runaway evolution of SARS-CoV-2 leading to the highly evolved Delta strain

Ruan, Y.; Hou, M.; Tang, X.; He, X.; Lu, X.; Lu, J.; Wu, C.-I.; Wen, H.

10.1101/2021.12.30.474592 — evolutionary biology — Posted on 2022-01-04

3503 Heterogeneity of social cognition in temporo-parietal junction: Overlapping yet distinct representation between visual perspective-taking and theory of mind

Ogawa, K.; Matsuyama, Y.

10.1101/2022.01.04.474884 — neuroscience — Posted on 2022-01-04

3504 Proteomic identification of phosphorylation dependent Septin 7 interactors that drive dendritic spine formation

Yadav, S.; Byeon, S.; Werner, B.; Falter, R.; Davidsen, K.; Snyder, C.; Ong, S.-E.

10.1101/2022.01.04.474970 — neuroscience — Posted on 2022-01-04

3505 Dissociating encoding of memory and salience by manipulating long-term synaptic potentiation

Kaganovsky, K.; Plitt, M. H.; Yang, R.; Sando, R.; Giocomo, L. M.; Ding, J. B.; Südhof, T. C.

10.1101/2022.01.04.474865 — neuroscience — Posted on 2022-01-04

3506 The first sheep graph-based pan-genome reveals the spectrum of structural variations and their effects on tail phenotypes

Li, R.; Gong, M.; Zhang, X.; Wang, F.; Liu, Z.; Zhang, L.; Xu, M.; Zhang, Y.; Dai, X.; Zhang, Z.; Fang, W.; Yang, Y.; Zhang, H.; Fu, W.; Cao, C.; Yang, P.; Ghanatsaman, Z. A.; Negari, N. J.; Nanaei, H. A.; Yue, X.; Song, Y.; Lan, X.; Deng, W.; Wang, X.; Xiang, R.; Ibeagha-Awemu, E. M.; Heslop-Harrison, P.; Lenstra, J. A.; Gan, S.; Jiang, Y.

10.1101/2021.12.22.472709 — genomics — Posted on 2022-01-04

3507 Macrophages break interneuromast cell quiescence by intervening the inhibition of Schwann cells in zebrafish lateral line

Lin, M.-J.; Lee, C.-M.; Hsu, W.-L.; Chen, B.-C.; Lee, S.-J.

10.1101/2021.12.29.474498 — developmental biology — Posted on 2022-01-04

3508 Loci for prediction of penicillin and tetracycline susceptibility in Neisseria gonorrhoeae: a genome wide association study

Mortimer, T. D.; Zhang, J. J.; Ma, K. C.; Grad, Y. H.

10.1101/2021.08.03.454909 — microbiology — Posted on 2022-01-04

3509 Cellular perception of growth rate and the mechanistic origin of bacterial growth laws

Wu, C.; Balakrishnan, R.; Braniff, N.; Mori, M.; Manzanarez, G.; Zhang, Z.; Hwa, T.

10.1101/2021.10.16.464649 — systems biology — Posted on 2022-01-04

3510 Novel Methods for Elucidating Modality Importance in Multimodal Electrophysiology Classifiers

Ellis, C. A.; Sendi, M. S.; Zhang, R.; Carbajal, D. A.; Wang, M. D.; Miller, R. L.; Calhoun, V. D.

10.1101/2022.01.01.474276 — bioinformatics — Posted on 2022-01-04

3511 MorphData: Automating the data extraction process of morphological features of microglial cells in ImageJ

Campos, A. B.; Duarte-Silva, S.; Ambrosio, A. F.; Maciel, P.; Fernandes, B.

10.1101/2021.08.05.455282 — bioinformatics — Posted on 2022-01-04

3512 Further perceptions of probability: in defence of trial-by-trial estimation models

Forsgren, M.; Juslin, P.; van den Berg, R.

10.1101/2020.01.30.927558 — animal behavior and cognition — Posted on 2022-01-04

3513 A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius)

Brown, A. R.; Comai, K.; Mannino, D.; McCullough, H.; Meyers, H. C.; Donekal, Y.; The BIO306 Consortium, ; Graves, C. W.; Seidel, H. S.

10.1101/2021.05.19.444867 — genetics — Posted on 2022-01-04

3514 Cross-species incompatibility between a DNA satellite and the Drosophila Spartan homolog poisons germline genome integrity

Brand, C. L.; Levine, M. T.

10.1101/2021.08.13.455988 — evolutionary biology — Posted on 2022-01-04

3515 Ageing red deer alter their spatial behaviour and become less social

Albery, G. F.; Clutton-Brock, T. H.; Morris, A.; Morris, S.; Pemberton, J. M.; Nussey, D. H.; Firth, J. A.

10.1101/2021.06.11.448092 — ecology — Posted on 2022-01-04

3516 Sufu regulation of Hedgehog signaling in P19 cells is required for proper glial cell differentiation

Spice, D. M.; Dierolf, J.; Kelly, G. M.

10.1101/2021.08.24.457497 — developmental biology — Posted on 2022-01-04

3517 Regulation of neurofilament length and transport by a dynamic cycle of polymer severing and annealing

Uchida, A.; Peng, J.; Brown, A.

10.1101/2021.01.17.427018 — cell biology — Posted on 2022-01-04

3518 Dealing with the promise of metabarcoding in mega-event biomonitoring: EXPO2015 unedited data

Agostinetto, G.; Bruno, A.; Sandionigi, A.; Brusati, A.; Manzari, C.; Chiodi, A.; Siani, E.; Borruso, L.; Galimberti, A.; Pesole, G.; Labra, M.; Casiraghi, M.

10.1101/2022.01.02.474438 — molecular biology — Posted on 2022-01-04

3519 Conservation of the direct and indirect pathways dichotomy in mouse caudal striatum with uneven distribution of dopamine receptor D1- and D2-expressing neurons

Ogata, K.; Kadono, F.; Hirai, Y.; Inoue, K.-i.; Takada, M.; Karube, F.; Fujiyama, F.

10.1101/2021.11.04.467262 — neuroscience — Posted on 2022-01-04

3520 Distinct Alterations in Cerebellar Connectivity with Substantia Nigra and Ventral Tegmental Area in Parkinson's Disease

O'Shea, I. M.; Popal, H.; Olson, I. R.; Murty, V. P.; Smith, D. V.

10.1101/2021.05.13.443998 — neuroscience — Posted on 2022-01-04

3521 A Eukaryotic Circuit for Secretion-coupled Cellular Autonomy

Qiao, L.; Abd El-Hafeez, A. A.; Lo, I.-C.; Sinha, S.; Midde, K.; Ngo, T.; Aznar, N.; Lopez-Sanchez, I.; Gupta, V.; Farquhar, M.; Rangamani, P.; Ghosh, P.

10.1101/2021.03.18.436048 — systems biology — Posted on 2022-01-04

3522 Haplotype-aware pantranscriptome analyses using spliced pangenome graphs

Sibbesen, J. A.; Eizenga, J. M.; Novak, A. M.; Siren, J.; Chang, X.; Garrison, E.; Paten, B.

10.1101/2021.03.26.437240 — bioinformatics — Posted on 2022-01-04

3523 Simulated hemiparesis increases optimal spatiotemporal gait asymmetry but not metabolic cost

Johnson, R. T.; Bianco, N. A.; Finley, J.

10.1101/2021.12.20.473515 — bioengineering — Posted on 2022-01-04

3524 The AMA1-RON complex drives Plasmodium sporozoite invasion in the mosquito and mammalian hosts

Fernandes, P.; Loubens, M.; Le Borgne, R.; Marinach, C.; Ardin, B.; Briquet, S.; Vincensini, L.; Hamada, S.; Hoareau-Coudert, B.; Verbavatz, J.-M.; Weiner, A.; Silvie, O.

10.1101/2022.01.04.474787 — microbiology — Posted on 2022-01-04

3525 Siglec-5 is an inhibitory immune checkpoint molecule for human T cells

Vuchkovska, A.; Glanville, D.; Scurti, G.; White, P.; Nishimura, M. I.; Ulijasz, A.; Iwashima, M. J.

10.1101/2022.01.04.474948 — immunology — Posted on 2022-01-04

3526 Structure-function-dynamics relationships in the peculiar Planktothrix PCC7805 OCP1: impact of his-tagging and carotenoid type.

Wilson, A.; Andreeva, E. A.; Nizinski, S.; Talbot, L.; Hartmann, E.; Schlichting, I.; Burdzinski, G.; Sliwa, M.; KIRILOVSKY, D.; Colletier, J.-P.

10.1101/2022.01.04.474796 — biophysics — Posted on 2022-01-04

3527 Mobility of nucleosomes is regulated by their binding partners

Melters, D. P.; Neuman, K. C.; Rakshit, T.; Dalal, Y.

10.1101/2022.01.04.474986 — biophysics — Posted on 2022-01-04

3528 Control of bacterial anti-phage signaling by a WYL domain transcription factor

Blankenchip, C. L.; Nguyen, J. V.; Lau, R. K.; Ye, Q.; Gu, Y.; Corbett, K. D.

10.1101/2022.01.04.474952 — biophysics — Posted on 2022-01-04

3529 Identification of bacteria strains using the Recombinase Polymerase Amplification assay on a miniaturized solid-state pH sensor

Nguyen, A. H.; Malhotra, S.; Lau, M. P. H.; Cao, H.

10.1101/2022.01.04.474950 — bioengineering — Posted on 2022-01-04

3530 Reduced local mechanical stimuli in spaceflight diminishes osteocyte lacunar morphometry and spatial heterogeneity in mouse cortical bone

Coulombe, J. C.; Mullen, Z. K.; Wiens, A. M.; Fisher, L. E.; Lynch, M. E.; Stodieck, L. S.; Ferguson, V. L.

10.1101/2022.01.04.474962 — bioengineering — Posted on 2022-01-04

3531 Embracing enzyme promiscuity with activity-based compressed biosensing

Holt, B. A.; Lim, H. S.; Su, M.; Tuttle, M.; Liakakos, H.; Qiu, P.; Kwong, G. A.

10.1101/2022.01.04.474983 — bioengineering — Posted on 2022-01-04

3532 A Low-Cost, 3D-Printed Biosensor for Rapid Detection of Escherichia coli

Malhotra, S.; Pham, D. S.; Lau, M. P. H.; Nguyen, A. H.; Cao, H.

10.1101/2022.01.04.474944 — bioengineering — Posted on 2022-01-04

3533 Rotavirus RNA chaperone mediates global transcriptome-wide increase in RNA backbone flexibility

Coria, A.; Wienecke, A.; Borodavka, A.; Laederach, A.

10.1101/2022.01.04.474988 — biochemistry — Posted on 2022-01-04

3534 The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn2+-binding domain essential for ligand binding and activity

Sander, S.; Gattkowski, E.; Pick, J.; Fliegert, R.; Tidow, H.

10.1101/2022.01.04.474898 — biochemistry — Posted on 2022-01-04

3535 Understanding host response to infectious salmon anaemia virus in an Atlantic salmon cell line using single-cell RNA sequencing

Gervais, O.; Gratacap, R.; Papadopoulou, A.; Houston, R. D.; Hassan, M. A.; Robledo, D.

10.1101/2022.01.04.474990 — genomics — Posted on 2022-01-04

3536 New genomic signals underlying the emergence of human proto-genes

Grandchamp, A.; Berk, K.; Dohmen, E.; Bornberg-Bauer, E.

10.1101/2022.01.04.474757 — genomics — Posted on 2022-01-04

3537 Gene expression profiles of some prognostic markers in a human breast cell line (MCF7) exposed to Curcumin nanoparticles and nanocapsules

Shaker, E.; Nasr, G. M.; Moawad, M.

10.1101/2022.01.04.474885 — genetics — Posted on 2022-01-04

3538 Guardian crypt-base-goblet-cells protect the human colonic stem cell niche by triggering cholinergic calcium signal-dependent MUC2 secretion and luminal flushing

Pelaez-Llaneza, N.; Jones, V.; Kam, C.; Lee, A.; Parris, A.; Tattan, S.; Loader, M.; Champion, J.; Russam, G.; Miller, B.; Juge, N.; Wharton, R.; Speakman, C.; Kapur, S.; Hernon, J.; Stearns, A.; Shaik, I.; Pal, A.; Tsigka, A.; Batsoulis, D.; Williams, M. R.

10.1101/2022.01.04.474646 — cell biology — Posted on 2022-01-04

3539 Histone deacetylase inhibitor overrides the effect of soft hydrogel on the mechanoresponse of human mesenchymal stem cells

Joshi, R.; Murlidharan, P.; Yadav, P.; Dharnidharka, V.; Majumder, A.

10.1101/2022.01.04.474891 — cell biology — Posted on 2022-01-04

3540 Thiamine metabolism genes in diatoms are not regulated by thiamine despite the presence of predicted riboswitches

Llavero-Pasquina, M.; Geisler, K.; Holzer, A.; Mehrshahi, P.; Mendoza-Ochoa, G. I.; Newsad, S.; Davey, M. P.; Smith, A. G.

10.1101/2022.01.04.474978 — molecular biology — Posted on 2022-01-04

3541 Enhanced loss of retinoic acid network genes in Xenopus laevis achieves a tighter signal regulation

Abbou, T.; Bendelac-Kapon, L.; Sebag, A.; Fainsod, A.

10.1101/2022.01.04.474867 — molecular biology — Posted on 2022-01-04

3542 Core Microbiota Drive the Prevalence of Extracellular Antibiotic Resistome in the Water Compartments

Yu, K.-F.; Li, P.; Huang, Y.; Yang, J.; Li, H.; Xie, Y.; Li, R.; Zhang, B.; He, Y.

10.1101/2022.01.04.474879 — microbiology — Posted on 2022-01-04

3543 Human land-use impacts viral diversity and abundance in a New Zealand river

French, R.; Charon, J.; Le Lay, C.; Muller, C.; Holmes, E. C.

10.1101/2022.01.04.474996 — microbiology — Posted on 2022-01-04

3544 Exploring the onset of B12-based mutualisms using a recently evolved Chlamydomonas auxotroph and B12-producing bacteria

Bunbury, F.; Deery, E.; Sayer, A.; Bhardwaj, V.; Harrison, E.; Warren, M. J.; Smith, A. G.

10.1101/2022.01.04.474942 — microbiology — Posted on 2022-01-04

3545 Multivalent interactions drive the Toxoplasma AC9:AC10:ERK7 complex to concentrate ERK7 in the apical cap

Back, P. S.; O'Shaughnessy, W. J.; Moon, A. S.; Dewangan, P. S.; Reese, M. L.; Bradley, P. J.

10.1101/2022.01.04.474968 — microbiology — Posted on 2022-01-04

3546 A Comparison Of Fecal Glucocorticoid Metabolite Concentration And Gut Microbiota Diversity In Bonobos (Pan paniscus)

Hickmott, A. J.; Boose, K. J.; Wakefield, M. L.; Brand, C. M.; Snodgrass, J. J.; Ting, N.; White, F. J.

10.1101/2022.01.04.474930 — microbiology — Posted on 2022-01-04

3547 GWAS and functional studies implicate a role for altered DNA repair in the evolution of drug resistance in Mycobacterium tuberculosis

Nandicoori, V. K.; Naz, S.; Paritosh, K.; Sanyal, P.; Khan, S.; Singh, Y.; Varshney, U.

10.1101/2022.01.04.474954 — microbiology — Posted on 2022-01-04

3548 Wnt5A supports antigen cross-presentation and CD8 T cell activation.

Sarraf, T. R.; Sen, M.

10.1101/2022.01.04.474906 — immunology — Posted on 2022-01-04

3549 Mosquito Olfactory Response Ensemble: a curated database of behavioral and electrophysiological responses enables pattern discovery

Gupta, A.; Singh, S. S.; Mittal, A. M.; Singh, P.; Goyal, S.; Kannan, K. R.; Gupta, A. K.; Gupta, N.

10.1101/2022.01.04.474842 — neuroscience — Posted on 2022-01-04

3550 Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learning

Daniels, K. G.; Wang, S.; Simic, M. S.; Bhargava, H. K.; Capponi, S.; Tonai, Y.; Yu, W.; Bianco, S.; Lim, W. A.

10.1101/2022.01.04.474985 — synthetic biology — Posted on 2022-01-04

3551 Improving disease resistance in plants by editing the epigenome

Veley, K. M.; Elliott, K.; Jensen, G.; Zhong, Z.; Feng, S.; Yoder, M.; Gilbert, K. B.; Berry, J. C.; Ghoshal, B.; Gallego-Bartolome, J.; Norton, J.; Motomura-Wages, S.; Carrington, J. C.; Jacobsen, S. E.; Bart, R.

10.1101/2022.01.04.474801 — plant biology — Posted on 2022-01-04

3552 Transglutaminase mediated asprosin oligomerization allows its tissue storage as fibers

Morcos, Y. A.; Pryymachuk, G.; Hoffmann, T.; Luetke, S.; Gerken, A.; Piekarek, N.; Odenthal, M.; Drebber, U.; Bloch, W.; Callewaert, B.; Paulsson, M.; Hucklenbruch-Rother, E.; Sengle, G.

10.1101/2022.01.04.474899 — biochemistry — Posted on 2022-01-04

3553 Structural basis of Omicron neutralization by affinity-matured public antibodies

Sheward, D. J.; Pushparaj, P.; Das, H.; Kim, C.; Kim, S.; Hanke, L.; Dyrdak, R.; McInerney, G. M.; Albert, J.; Murrell, B.; Karlsson Hedestam, G. B.; Hällberg, B. M.

10.1101/2022.01.03.474825 — immunology — Posted on 2022-01-04

3554 Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

wang, x.; Wang, T.; Ge, J.; Zhang, L.; Lan, J.; He, X.; Ren, Y.; Wang, Z.; Zhou, H.; Fan, S.; Zhu, C.; Liu, D.; Shao, B.; Liu, T.-Y.; Wang, Q.

10.1101/2022.01.03.474855 — biophysics — Posted on 2022-01-04

3555 Caveolae promote successful abscission by controlling intercellular bridge tension during cytokinesis

ANDRADE, V.; Bai, J.; GUPTA, N.; Jimenez, A.-J.; Delevoye, C.; Lamaze, C.; Echard, A.

10.1101/2022.01.04.474800 — cell biology — Posted on 2022-01-04

3556 Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

Yang, X.; Dickmander, R. J.; Bayati, A.; Taft-Benz, S. A.; Smith, J. L.; Brown, J. W.; Lenarcic, E. M.; Yount, B. L.; Chang, E.; Axtman, A. D.; Baric, R. S.; Heise, M. T.; McPherson, P. S.; Moorman, N. J.; Willson, T. M.

10.1101/2022.01.03.474779 — cell biology — Posted on 2022-01-04

3557 A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron

Yuan, T. Z.; Lucas, C.; Monteiro, V. S.; Iwasaki, A.; Yang, M. L.; Nepita, H. F.; Lujan Hernandez, A. G.; Taft, J. M.; Frei, L.; Reddy, S. T.; Weber, C.; Malobisky, K. P.; Mesquita, R.; Sato, A.

10.1101/2022.01.04.474803 — immunology — Posted on 2022-01-04

3558 Maternal cytokine response after SARS-CoV-2 infection during pregnancy

Gigase, F. A. J.; Molenaar, N. M.; Missall, R. D.; Rommel, A.-S.; Lieb, W.; Ibroci, E.; Ohrn, S.; Lynch, J.; Krammer, F.; Brody, R.; Jessel, R. H.; Sperling, R. S.; Lesseur, C.; Callipari, F.; Galang, R. R.; Snead, M. C.; Janevic, T.; Stone, J.; Howell, E. A.; Chen, J.; Pop, V. J. M.; Dolan, S. M.; Bergink, V.; De Witte, L. D.

10.1101/2022.01.04.474908 — immunology — Posted on 2022-01-04

3559 The tetraspanin TSPAN5 regulates AMPARs exocytosis by interacting with the AP-4 complex

Moretto, E.; Longatti, A.; Miozzo, F.; Bonnet, C.; Coussen, F.; Jaudon, F.; Cingolani, L.; Passafaro, M.

10.1101/2022.01.04.474946 — neuroscience — Posted on 2022-01-04

3560 The generation of a Nutm1 knock-in reporter mouse line for imaging post-meiotic spermatogenesis

Hakun, M. C.; Rossant, J.; Gu, B.

10.1101/2022.01.04.474959 — developmental biology — Posted on 2022-01-04

3561 mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system

Dahl, K. D.; Hathaway, H. A.; Almeida, A. R.; Bourne, J.; Brown, T. L.; Finseth, L. T.; Wood, T. L.; Macklin, W. B.

10.1101/2022.01.04.474811 — developmental biology — Posted on 2022-01-04

3562 hPSC-Derived Enteric Ganglioids Model Human ENS Development and Function

Majd, H.; Samuel, R. M.; Ramirez, J. T.; Kalantari, A.; Barber, K.; Ghazizadeh, Z.; Chemel, A. K.; Cesiulis, A.; Richter, M. N.; Das, S.; Keefe, M. G.; Wang, J.; Shiv, R.; McCann, C. J.; Bhat, S.; Khoroshkin, M.; Yu, J.; Nowakowski, T. J.; Goodarzi, H.; Thapar, N.; Kaltschmidt, J. A.; Fattahi, F.

10.1101/2022.01.04.474746 — developmental biology — Posted on 2022-01-04

3563 Generation of Vascularized Brain Organoids to Study Neurovascular Interactions

Luo, Z.-G.; Sun, X.-Y.; Ju, X.-C.; Li, Y.; Zeng, P.-M.; Wu, J.; Shen, L.-B.; Chen, Y.

10.1101/2022.01.04.474960 — developmental biology — Posted on 2022-01-04

3564 The onset of whole-body regeneration in Botryllus schlosseri: morphological and molecular characterization

Ricci, L.; Salmon, B.; Olivier, C.; Andreoni-Pham, R.; Chaurasia, A.; Alie, A.; Tiozzo, S.

10.1101/2022.01.04.472827 — developmental biology — Posted on 2022-01-04

3565 The Mitochondrial RNA Granule is Necessary for Parkinsonism-Associated Metal Toxicity

Werner, E.; Gokhale, A.; Ackert, M.; Xu, C.; Wen, Z.; Roberts, A. M.; Roberts, B. R.; Vrailas-Mortimer, A. R.; Crocker, A. J.; Faundez, V.

10.1101/2022.01.04.474973 — cell biology — Posted on 2022-01-04

3566 ZYG-9ch-TOG promotes the stability of acentrosomal poles via regulation of spindle microtubules in C. elegans oocyte meiosis

Cavin-Meza, G.; Mullen, T. J.; Wolff, I. D.; Czajkowski, E. R.; Divekar, N. S.; Finkle, J. D.; Wignall, S. M.

10.1101/2022.01.04.474888 — cell biology — Posted on 2022-01-04

3567 Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling

Jobin, M.-L.; De Smedt-Peyrusse, V.; Ducrocq, F.; Oummadi, A.; Baccouch, R.; Hauge Pedersen, M.; Medel Lacruz, B.; Van-Delft, P.; Fouillen, L.; Mongrand, S.; Selent, J.; Tolentino-Cortez, T.; Barreda-Gomez, G.; Gregoire, S.; Masson, E.; Durroux, T.; Javitch, J. A.; Guixa-Gonzalez, R.; Alves, I.; Trifilieff, P.

10.1101/2022.01.04.474945 — cell biology — Posted on 2022-01-04

3568 PLEKHA5 regulates mitotic progression by promoting APC/C localization to microtubules

Cao, X.; Shami Shah, A.; Sanford, E. J.; Smolka, M. B.; Baskin, J. M.

10.1101/2022.01.04.474939 — cell biology — Posted on 2022-01-04

3569 SARS-CoV-2 entry sites are present in all structural elements of the human glossopharyngeal and vagal nerves: clinical implications

Vitale-Cross, L.; Szalayova, I.; Scoggins, A.; Palkovits, M.; Mezey, E.

10.1101/2021.12.30.474580 — neuroscience — Posted on 2022-01-04

3570 Low centrosome numbers correlate with higher aggressivity in ovarian cancer

Morretton, J.-P.; Simon, A.; Herbette, A.; Barbazan, J.; Perez-Gonzalez, C.; Cosson, C.; Mboup, B.; Latouche, A.; Popova, T.; Kieffer, Y.; Gestraud, P.; Bataillon, G.; Becette, V.; Meseure, D.; Nicolas, A.; Mariani, O.; Vincent-Salomon, A.; Stern, M.-H.; Mechta-Grigoriou, F.; Roman Roman, S.; Vignjevic, D. M.; Rouzier, R.; Sastre-Garau, X.; Goundiam, O.; Basto, R.

10.1101/623983 — cancer biology — Posted on 2022-01-04

3571 Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir (PF-07321332)

Ullrich, S.; Ekanayake, K. B.; Otting, G.; Nitsche, C.

10.1101/2021.11.28.470226 — biochemistry — Posted on 2022-01-04

3572 Identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species

Heinzelman, P.; Greenhalgh, J.; Romero, P. A.

10.1101/2021.03.16.435705 — biochemistry — Posted on 2022-01-04

3573 Specialized protrusions coordinate migratory border cell cluster cohesion via Scribble, Cdep, and Rac

Campanale, J. P.; Mondo, J. A.; Montell, D. J.

10.1101/2022.01.04.474957 — cell biology — Posted on 2022-01-04

3574 Fasting Induces a Highly Resilient Deep Quiescent State in Muscle Stem Cells via Ketone Body Signaling

Benjamin, D. I.; Both, P. I.; Benjamin, J. S.; Nutter, C. W.; Tan, J. H.; Kang, J. I.; Machado, L. A.; Klein, J. D. D.; Morree, A. d.; Kim, S. I.; Liu, L. I.; Dulay, H.; Feraboli, L.; Louie, S. M.; Nomura, D. K.; Rando, T. A.

10.1101/2022.01.04.474961 — cell biology — Posted on 2022-01-04

3575 E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins

Dewson, G.; Huang, A. S.; Chin, H. S.; Reljic, B.; Djajawi, T. M.; Tan, I. K.; Stroud, D. A.; Huang, D. C. S.; van Delft, M. F.

10.1101/2022.01.04.474880 — cell biology — Posted on 2022-01-04

3576 Regulation of PDF Receptor signaling controlling daily locomotor rhythms in Drosophila

Li, W.; Trigg, J.; Taghert, P. H.

10.1101/2022.01.03.474875 — neuroscience — Posted on 2022-01-04

3577 Co-infection of Candidatus Piscichlamydia trichopodus (order Chlamydiales) and Henneguya sp (Myxosporea, Myxobolidae) in snakeskin gourami Trichopodus pectoralis (Regan 1910)

Dinh-Hung, N.; Dong, H. T.; Soontara, C.; Rodkhum, C.; Nimitkul, S.; Srisapoome, P.; Chatchaiphan, S.; Kayansamruaj, P.

10.1101/2021.06.01.446678 — pathology — Posted on 2022-01-04

3578 The evolution of widespread recombination suppression on the Dwarf Hamster (Phodopus) X chromosome

Moore, E. C.; Thomas, G. W. C.; Mortimer, S.; Kopania, E. E. K.; Hunnicutt, K. E.; Clare-Salzler, Z. J.; Larson, E. E.; Good, J. M.

10.1101/2021.11.15.468705 — genomics — Posted on 2022-01-04

3579 Insights from the genomes of four diploid Camelina spp.

Martin, S. L.; Toro, B. L.; James, T.; Sauder, C. A.; Laforest, M.

10.1101/2021.08.23.455123 — genomics — Posted on 2022-01-04

3580 Landscaping the behavioural ecology of primate stone tool use

Almeida-Warren, K.; Matsuzawa, T.; Carvalho, S.

10.1101/2021.08.24.457369 — ecology — Posted on 2022-01-04

3581 Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant SARS-CoV-2 isolates

Bojkova, D.; Widera, M.; Ciesek, S.; Wass, M. N.; Michaelis, M.; Cinatl, J. N.

10.1101/2022.01.03.474773 — microbiology — Posted on 2022-01-04

3582 Beyond dimension reduction: Stable electric fields emerge from and allow representational drift

Pinotsis, D.; Miller, E. K.

10.1101/2021.08.22.457247 — neuroscience — Posted on 2022-01-04

3583 Molecular and cellular adaptations in hippocampal parvalbumin neurons mediate behavioral responses to chronic social stress

Bhatti, D. L.; Medrihan, L.; Chen, M. X.; Jin, J.; McCabe, K.; Wang, W.; Azevedo, E. P.; Ledo, J. H.; Kim, Y.

10.1101/2021.09.14.459024 — neuroscience — Posted on 2022-01-04

3584 Quantifying the Morphology and Mechanisms of Cancer Progression in 3D in-vitro environments: Integrating Experiments and Multiscale Models

Dimitriou, N. M.; Flores-Torres, S.; Kinsella, J. M.; Mitsis, G. D.

10.1101/2021.11.16.468856 — systems biology — Posted on 2022-01-04

3585 Transcription Factor EB regulates phosphatidylinositol-3-phosphate levels on endomembranes and alters lysosome positioning in the bladder cancer model

Mathur, P.; De Barros Santos, C.; Lachuer, H.; Latge, B.; Radvanyi, F.; Goud, B.; Schauer, K.

10.1101/2020.07.10.196931 — cancer biology — Posted on 2022-01-04

3586 The SARS-CoV-2 infection in Thailand: analysis of spike variants complemented by protein structure insights

Ittisoponpisan, S.; Yahangkiakan, S.; Sternberg, M. J. E.; David, A.

10.1101/2022.01.01.474713 — bioinformatics — Posted on 2022-01-04

3587 Intermittent KHz-frequency electrical stimulation selectively engages small unmyelinated vagal afferents

Chang, Y.-C.; Ahmed, U.; Jayaprakash, N.; Mughrabi, I.; Lin, Q.; Wu, Y.-C.; Gerber, M.; Abbas, A.; Daytz, A.; Gabalski, A. H.; Ashville, J.; Dokos, S.; Rieth, L.; Datta-Chaudhuri, T.; Tracey, K.; Guo, T.; Al-Abed, Y.; Zanos, S.

10.1101/2021.01.30.428827 — bioengineering — Posted on 2022-01-04

3588 Directed evolution of angiotensin-converting enzyme 2 (ACE2) variants with enhanced peptidase activity profiles for novel therapeutic applications

Heinzelman, P.; Romero, P. A.

10.1101/2022.01.03.474817 — biochemistry — Posted on 2022-01-04

3589 Population genetics of transposable element load: a mechanistic account of observed overdispersion

Smith, R. D.; Puzey, J.; Conradi Smith, G. D.

10.1101/2020.11.16.382945 — genomics — Posted on 2022-01-04

3590 Sex-specific association between urinary kisspeptin and pubertal development

de Freitas, R. S.; Franca, T. F. A.; Pompeia, S.

10.1101/2021.07.12.452029 — developmental biology — Posted on 2022-01-04

3591 An integrative process-based model for biomass and yield estimation of hardneck garlic (Allium sativum)

Yun, K.; Shin, M.; Moon, K. H.; Kim, S.-H.

10.1101/2021.11.04.467009 — plant biology — Posted on 2022-01-04

3592 Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

Meister, M. T.; Groot Koerkamp, M. J. A.; de Souza, T.; Breunis, W. B.; Frazer-Mendelewska, E.; Brok, M.; DeMartino, J.; Manders, F.; Calandrini, C.; Kerstens, H. H. D.; Janse, A.; Dolman, M. E. M.; Eising, S.; Langenberg, K. P. S.; van Tuil, M.; Knops, R. R. G.; Terwisscha van Scheltinga, S.; Hiemcke-Jiwa, L. S.; Flucke, U.; Merks, J. H. M.; van Noesel, M. M.; Tops, B. B. J.; Hehir-Kwa, J. Y.; Kemmeren, P.; Molenaar, J. J.; van de Wetering, M.; van Boxtel, R.; Drost, J.; Holstege, F. C. P.

10.1101/2022.01.03.474504 — cancer biology — Posted on 2022-01-04

3593 Calculation of centralities in protein kinase A

Kornev, A. P.; Aoto, P.; Taylor, S.

10.1101/2022.01.03.474877 — bioinformatics — Posted on 2022-01-04

3594 Clustering Deviation Index (CDI): A robust and accurate unsupervised measure for evaluating scRNA-seq data clustering

Fang, J.; Chan, C.; Owzar, K.; Wang, L.; Qin, D.; Li, Q.-J.; Xie, J.

10.1101/2022.01.03.474840 — bioinformatics — Posted on 2022-01-04

3595 LINE-1 Retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5'-single cell RNA-Seq

McKerrow, W.; Doudican, N.; Frazzette, N.; Evans, S. A.; Rocha, A.; Kagermazova, L.; Sedivy, J.; Neretti, N.; Carucci, J.; Boeke, J. D.; Fenyö, D.

10.1101/2021.01.19.427347 — bioinformatics — Posted on 2022-01-04

3596 One-step pipetting of barcoded planar microparticles into compact monolayer assembling chip for efficient readout of multiplexed immunoassay

Bae, S.; Lee, D.; Na, H.; Jang, J.; Kwon, S.

10.1101/2022.01.03.474850 — bioengineering — Posted on 2022-01-04

3597 Local assembly of long reads enables phylogenomics of transposable elements in a polyploid cell line

Han, S.; Dias, G. B.; Basting, P. J.; Viswanatha, R.; Perrimon, N.; Bergman, C. M.

10.1101/2022.01.04.471818 — genomics — Posted on 2022-01-04

3598 Systematic whole-genome sequencing reveals an unexpected diversity among actinomycetoma pathogens and provides insights into their antibacterial susceptibilities

Watson, A. K.; Kepplinger, B.; Bakhiet, S. M.; Mhmoud, N. A.; Goodfellow, M.; Fahal, A. H.; Errington, J.

10.1101/2022.01.03.474876 — genomics — Posted on 2022-01-04

3599 E.PAGE: A curated database and enrichment tool to predict modules associated with gene-environment interactions

Muralidharan, S.; Zahir, F.; Mehdi, A. M.

10.1101/2022.01.03.474848 — genomics — Posted on 2022-01-04

3600 randtip, a generalized framework to expand incomplete phylogenies using non-molecular phylogenetic information

Ramos-Gutierrez, I.; Lima, H.; Molina-Venegas, R.

10.1101/2022.01.04.474924 — evolutionary biology — Posted on 2022-01-04

3601 Carbon content, carbon fixation yield and dissolved organic carbon release from diverse marine nitrifiers

Bayer, B.; McBeain, K.; Carlson, C. A.; Santoro, A. E.

10.1101/2022.01.04.474793 — ecology — Posted on 2022-01-04

3602 Hbxip (Lamtor5) is essential for embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1

Qin, Y.; Ni, P.; Zhang, Q.; Wang, X.; Du, X.; Yin, Z.; Wang, L.; Ye, L.; Chen, L.

10.1101/2022.01.04.474860 — developmental biology — Posted on 2022-01-04

3603 Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos

Edwards, H. E.; Souder, J. P.; Gorelick, D. A.

10.1101/2022.01.04.474920 — developmental biology — Posted on 2022-01-04

3604 Hydrothermal Synthesis of Clove Bud-Derived Multifunctional Carbon Dots Passivated with PVP- Antioxidant, Catalysis, and Bioimaging Applications

Pandey, A. K.; Bankoti, K.; Nath, T. K.; Dhara, S.

10.1101/2021.11.29.470381 — cell biology — Posted on 2022-01-04

3605 The ESKAPE mobilome contributes to the spread of antimicrobial resistance and CRISPR-mediated conflict between mobile genetic elements

Botelho, J.; Cazares, A.; Schulenburg, H.

10.1101/2022.01.03.474784 — microbiology — Posted on 2022-01-04

3606 The 2009 pandemic H1N1 hemagglutinin stalk remained antigenically stable after circulating in humans for a decade

Christensen, S. R.; Martin, E. T.; Petrie, J.; Monto, A.; Hensley, S. E.

10.1101/2022.01.03.474869 — microbiology — Posted on 2022-01-04

3607 Controls on the isotopic composition of microbial methane

Gropp, J.; Jin, Q.; Halevy, I.

10.1101/2021.09.14.460204 — microbiology — Posted on 2022-01-04

3608 A Single Intranasal Dose of Bacterial Therapeutics to Calves Confers Longitudinal Modulation of the Nasopharyngeal Microbiota

Amat, S.; Timsit, E.; Workentine, M.; Schwinghamer, T.; van der Meer, F.; Guo, Y.; Alexander, T.

10.1101/2022.01.03.474870 — microbiology — Posted on 2022-01-04

3609 BDSF is a degradation-prone quorum-sensing signal detected by the histidine kinase RpfC of Xanthomonas campestris pv. campestris

Tian, X.-Q.; Wu, Y.; Cai, Z.; Qian, W.

10.1101/2022.01.03.474871 — microbiology — Posted on 2022-01-04

3610 S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice

Sen Chaudhuri, A.; Yeh, Y.-W.; Sun, J.-B.; Zewdie, O.; Jin, T.; Wei, B.; Holmgren, J.; Zou, X.

10.1101/2022.01.04.474916 — immunology — Posted on 2022-01-04

3611 Comprehensive antibody profiling of mRNA vaccination in children

Bartsch, Y. C.; St Denis, K. J.; Kaplonek, P.; Kang, J.; Lam, E. C.; Burns, M. D.; Farkas, E. J.; Davis, J.; Boribong, B.; Edlow, A. G.; Fasano, A.; Shreffler, W.; Zavadska, D.; Johnson, M.; Goldblatt, D.; Balazs, A. B.; Yonker, L. M.; Galit, A.

10.1101/2021.10.07.463592 — immunology — Posted on 2022-01-04

3612 Encoding of speech in convolutional layers and the brain stem based on language experience

Begus, G.; Zhou, A.; Zhao, C.

10.1101/2022.01.03.474864 — neuroscience — Posted on 2022-01-04

3613 Biological Aging of CNS-Resident Cells Alters the Clinical Course and Immunopathology of Autoimmune Demyelinating Disease

Atkinson, J. R.; Jerome, A. D.; Sas, A. R.; Munie, A.; Wang, C.; Ma, A.; Arnold, W. D.; Segal, B. M.

10.1101/2021.12.26.473589 — neuroscience — Posted on 2022-01-04

3614 Hippocampal Volume, Neurite Density and Trace Eye-Blink Conditioning in Young Children

Vieites, V.; Ralph, Y.; Reeb-Sutherland, B.; Dick, A. S.; Mattfeld, A. T.; Pruden, S. M.

10.1101/2022.01.03.474711 — neuroscience — Posted on 2022-01-04

3615 Effects of tDCS on the attentional blink revisited: A statistical evaluation of a replication attempt

Reteig, L. C.; Newman, L. A.; Ridderinkhof, K. R.; Slagter, H. A.

10.1101/2021.06.16.448698 — neuroscience — Posted on 2022-01-04

3616 Quality assessment of anatomical MRI images from Generative Adversarial Networks: human assessment and image quality metrics

Treder, M. S.; Codrai, R.; Tsvetanov, K. A.

10.1101/2022.01.03.474792 — neuroscience — Posted on 2022-01-04

3617 Visual search training benefits from the integrative effect of enhanced covert attention and optimized overt eye movements

Zhang, Q.; Huang, Z.; Li, L.; Li, S.

10.1101/2022.01.03.474790 — neuroscience — Posted on 2022-01-04

3618 Structural insights into an evolutionary turning-point of photosystem I from prokaryotes to eukaryotes

Kato, K.; Nagao, R.; Ueno, Y.; Yokono, M.; Suzuki, T.; Jiang, T.-Y.; Dohmae, N.; Akita, F.; Akimoto, S.; Miyazaki, N.; Shen, J.-R.

10.1101/2022.01.03.474851 — plant biology — Posted on 2022-01-04

3619 Trait variation between and within Andes and coastal mountain ranges in the iconic South American tree Araucaria araucana in Chile

McIntosh, M.; Gonzalez-Campos, J.; Demaree, P.; Toro-Salamanca, O.; Ipinza, R.; Bustamante-Sanchez, M.; Hasbun, R.; Nelson, C.

10.1101/2022.01.04.474828 — plant biology — Posted on 2022-01-04

3620 A global Anopheles gambiae gene co-expression network constructed from hundreds of experimental conditions with missing values

Kuang, J.; Buchon, N.; Michel, K.; Scoglio, C. M.

10.1101/2022.01.03.474847 — bioinformatics — Posted on 2022-01-04

3621 Nm-Nano: Predicting 2'-O-methylation (Nm) Sites in Nanopore RNA Sequencing Data

Salem, D. H.; Ariyur, A.; Daulatabad, S. V.; Mir, Q.; Janga, S. C.

10.1101/2022.01.03.473214 — bioinformatics — Posted on 2022-01-04

3622 Characterizing RNA-binding Ligands on Structures, Chemical Information, Binding Affinity and Drug-likeness

Fan, C.; Wang, X.; Wang, T.; Zhao, H.

10.1101/2022.01.03.474753 — bioinformatics — Posted on 2022-01-04

3623 Tree House Explorer: A Novel Genome Browser for Phylogenomics

Harris, A. J.; Foley, N. M.; Williams, T. L.; Murphy, W. J.

10.1101/2022.01.03.474706 — bioinformatics — Posted on 2022-01-04

3624 Magnetic torque-driven living microrobots for enhanced tumor infiltration

Gwisai, T.; Mirkhani, N.; Christiansen, M. G.; Nguyen, T. T.; Ling, V.; Schuerle, S.

10.1101/2022.01.03.473989 — bioengineering — Posted on 2022-01-04

3625 Plasma and ovarian metabolomics responses to chronic stress in female mice

Zeleznik, O. A.; Hunag, T.; Patel, C. J.; Poole, E. M.; Clish, C. B.; Armaiz-Pena, G. N.; Nagaraja, A. S.; Eliassen, A. H.; Shutta, K. H.; Balasubramanian, R.; Kubzansky, L. D.; Hankinson, S. E.; Sood, A. K.; Tworoger, S. S.

10.1101/2022.01.03.474852 — animal behavior and cognition — Posted on 2022-01-04

3626 High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets

MacMillan, H. J.; Kong, Y.; Calvo-Roitberg, E.; Alonso, L. C.; Pai, A. A.

10.1101/2022.01.03.474854 — genomics — Posted on 2022-01-04

3627 The RNA binding protein Swm is critical for Drosophila melanogaster intestinalprogenitor cell maintenance

Ariyapala, I. S.; Buddika, K.; Hundley, H. A.; Calvi, B.; Sokol, N.

10.1101/2022.01.03.474858 — genetics — Posted on 2022-01-04

3628 Resonant fluctuations of selection pressure exponentially accelerate fitness valley crossing

Di Salvo, M. E.; Reynolds, K. A.; Lin, M. M.

10.1101/2022.01.03.474754 — evolutionary biology — Posted on 2022-01-04

3629 Evolutionary jumps in bacterial GC content

Mahajan, S.; Agashe, D.

10.1101/2021.02.16.431469 — evolutionary biology — Posted on 2022-01-04

3630 Effects of diversifying the planting period of maize on herbivorous and their natural enemies

Clemente-Orta, G. M.; Alvarez, H. A.; Madeira, F.; Albajes, R.

10.1101/2022.01.03.474813 — ecology — Posted on 2022-01-04

3631 Testing a theoretical framework for the environment-species abundance paradigm: a new approach to the Abundant Centre Hypothesis

Maitra, A.; Pandit, R.; Mungee, M.; Athreya, R.

10.1101/2022.01.03.474819 — ecology — Posted on 2022-01-04

3632 Modelling the distribution of rare invertebrates by correcting class imbalance and spatial bias

Gaul, W. B.; Sadykova, D.; White, H. J.; Leon-Sanchez, L.; Caplat, P.; Emmerson, M. C.; Yearsley, J. M.

10.1101/2022.01.03.474856 — ecology — Posted on 2022-01-04

3633 Dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification

Kolay, S.; Vega, A. R.; Dodd, D. A.; Perez, V. A.; Kashmer, O. M.; White, C. L.; Diamond, M. I.

10.1101/2022.01.03.474802 — cell biology — Posted on 2022-01-04

3634 Nested spatial and temporal modeling of environmental conditions associated with genetic markers of Vibrio parahaemolyticus in Washington state Pacific oysters

Fries, B.; Davis, B. J. K.; Corrigan, A. E.; DePaola, A.; Curriero, F. C.

10.1101/2022.01.03.471994 — microbiology — Posted on 2022-01-04

3635 Low vision impairs implicit sensorimotor adaptation in response to small errors, but not large errors

Tsay, J. S.; Tan, S.; Chu, M.; Ivry, R. B.; Cooper, E. A.

10.1101/2022.01.03.474829 — neuroscience — Posted on 2022-01-04

3636 Keeping time and rhythm by replaying a sensory-motor engram

de Lafuente, V.; Jazayeri, M.; Merchant, H.; Garcia-Garibay, O.; Cadena-Valencia, J.; Malagon, A. M.

10.1101/2022.01.03.474812 — neuroscience — Posted on 2022-01-04

3637 The structured flow on the brain's resting state manifold

Fousek, J.; Rabuffo, G.; Gudibanda, K.; Sheheitli, H.; Jirsa, V.; Petkoski, S.

10.1101/2022.01.03.474841 — neuroscience — Posted on 2022-01-04

3638 Got Milk? Maternal immune activation during the mid-lactational period affects nutritional milk quality and adolescent offspring sensory processing in male and female rats

DeRosa, H.; Tran, H.; Kentner, A. C.

10.1101/2022.01.03.474857 — neuroscience — Posted on 2022-01-04

3639 Regulation of PDF Receptor signaling controlling daily locomotor rhythms in Drosophila

Li, W.; Trigg, J.; Taghert, P.

10.1101/2022.01.03.474875 — neuroscience — Posted on 2022-01-04

3640 Nearly maximal information gain due to time integration in central dogma reactions

Sarkar, S.; Rammohan, J.

10.1101/2022.01.02.474710 — systems biology — Posted on 2022-01-04

3641 An integrated approach to protein discovery and detection from complex biofluids

Luu, G. T.; Ge, C.; Tang, Y.; Li, K.; Cologna, S. M.; Burdette, J. E.; Su, J.; Sanchez, L. M.

10.1101/2022.01.03.474834 — cancer biology — Posted on 2022-01-04

3642 Molecular Dynamics of DNA Translocation by FtsK

Pajak, J.; Arya, G.

10.1101/2022.01.03.474797 — biophysics — Posted on 2022-01-04

3643 Interpreting tree ensemble machine learning models with endoR

Ruaud, A.; Pfister, N. A.; Ley, R. E.; Youngblut, N. D.

10.1101/2022.01.03.474763 — bioinformatics — Posted on 2022-01-04

3644 The last missing piece of the Triangle of U: the evolution of the tetraploid Brassica carinata genome

Yim, W. C.; Swain, M. L.; Ma, D.; An, H.; Bird, K. A.; Curdie, D. D.; Wang, S.; Ham, H. D.; Luzuriaga-Neira, A.; Kirkwood, J. S.; Hur, M.; Solomon, J. K. Q.; Harper, J. F.; Kosma, D. K.; Alvarez-Ponce, D.; Cushman, J. C.; Edger, P. P.; Mason, A. S.; Pires, J. C.; Tang, H.; Zhang, X.

10.1101/2022.01.03.474831 — genetics — Posted on 2022-01-04

3645 The evolution of sexual dichromatism in a large radiation of landfowls: re-examining the female-biased selection in Wallace's model

Li, Z.; Chen, D.; Dong, L.

10.1101/2022.01.02.474725 — evolutionary biology — Posted on 2022-01-04

3646 Explaining the microbial diversity conundrum: can microbiome composition be crucial for host fitness, while highly divergent among healthy individuals?

Daybog, I.; Kolodny, O.

10.1101/2022.01.03.474762 — evolutionary biology — Posted on 2022-01-04

3647 Phylogeographic analysis reveals an ancient East African origin of the human herpes simplexvirus 2 dispersal out-of-Africa.

Havens, J. L.; Calvignac-Spencer, S.; Merkel, K.; Burrel, S.; Boutolleau, D.; Wertheim, J. O.

10.1101/2022.01.03.474822 — evolutionary biology — Posted on 2022-01-04

3648 From smooth cortical gradients to discrete modules: spontaneous and topologically robust emergence of modularity in grid cells

Khona, M.; Chandra, S.; Fiete, I.

10.1101/2021.10.28.466284 — neuroscience — Posted on 2022-01-04

3649 A role for Lin28a in aging-associated decline of adult hippocampal neurogenesis

Hu, Z.; Ma, J.; Yue, H.; Li, X.; Wang, C.; Wang, L.; Sun, B.; Chen, Z.; Wang, L.; Gu, Y.

10.1101/2022.01.03.474756 — neuroscience — Posted on 2022-01-04

3650 Continuous Daily Head and Trunk Acceleration Recording for the Assessment of Bone Stimulation in Astronauts

Clement, G.; Sugita, Y.

10.1101/2022.01.03.474794 — neuroscience — Posted on 2022-01-04

3651 A memory-based theory of emotional disorders

Cohen, R. T.; Kahana, M. J.

10.1101/817486 — neuroscience — Posted on 2022-01-04

3652 The rosy future paradox: Positive future thinking without task relevance enhances negative biases and anxiety for aversive events

Montijn, N. D.; Gerritsen, L.; van Son, D.; Engelhard, I. M.

10.1101/2022.01.03.474768 — neuroscience — Posted on 2022-01-04

3653 Schild analysis of the interaction between parthenolide and cocaine on their effects onplanarian motility suggests an orthosteric relationship.

Kakuturu, J.; O'Brien, M.; Pagan, O. R.

10.1101/2022.01.02.474598 — pharmacology and toxicology — Posted on 2022-01-04

3654 Large-scale conformational changes of FhaC provide insights into the two-partner secretion mechanism

Sicoli, G.; Konijnenberg, A.; Guerin, J.; Hessmann, S.; Del Nero, E.; Hernandez-Alba, O.; Lecher, S.; Rouaut, G.; Mueggenburg, L.; Vezin, H.; CIANFERANI, S.; Sobott, F.; Schneider, R.; Jacob-Dubuisson, F.

10.1101/2021.11.09.467682 — biophysics — Posted on 2022-01-04

3655 Statistics or biology: the zero-inflation controversy about scRNA-seq data

Jiang, R.; Sun, T.; Song, D.; Li, J. J.

10.1101/2020.12.28.424633 — bioinformatics — Posted on 2022-01-04

3656 Construct a variable-length fragment library for de novo protein structure prediction

Feng, Q.; Hou, M.; Liu, J.; Zhao, K.; Zhang, G.

10.1101/2022.01.03.474755 — bioinformatics — Posted on 2022-01-04

3657 Correlation scan: identifying genomic regions that affect genetic correlations applied to fertility traits

Olasege, B. S.; Porto-Neto, L. R.; Tahir, M. S.; Gouveia, G. C.; Canovas, A.; Hayes, B.; Fortes, M.

10.1101/2021.11.05.467409 — genetics — Posted on 2022-01-04

3658 The genetic basis of structural colour variation in mimetic Heliconius butterflies

Brien, M. N.; Enciso Romero, J.; Lloyd, V. J.; Curran, E. V.; Parnell, A. J.; Morochz, C.; Salazar, P. A.; Rastas, P.; Zinn, T.; Nadeau, N. J.

10.1101/2021.04.21.440746 — evolutionary biology — Posted on 2022-01-04

3659 Gut melange a trois: fluctuating selection modulated by microbiota, host immune system, and antibiotics

Barreto, H. C.; Abreu, B.; Gordo, I.

10.1101/2021.12.30.474527 — evolutionary biology — Posted on 2022-01-04

3660 An investigation into the spatiotemporal patterns of the Nymphalid butterfly Vagrans egista sinha (Kollar, )

Pop, P.; Barwal, K. S.; Singh, R.; Pandey, P.; Singh, H. P.; Sondhi, S.

10.1101/2022.01.02.474748 — ecology — Posted on 2022-01-04

3661 Augmenting Recombinant Antibody Production in HEK293E Cells: Optimising Transfection and Culture Parameters

Heng, Z. S.-L.; Yeo, J. Y.; Koh, D. W.-S.; Gan, S. K.-E.; Ling, W.-L.

10.1101/2021.11.04.467283 — molecular biology — Posted on 2022-01-04

3662 Impairment of SARS-CoV-2 spike-glycoprotein maturation and fusion-activity by nitazoxanide: an effect independent of spike variants emergence

Riccio, A.; Santopolo, S.; Rossi, A.; Piacentini, S.; Rossignol, J.-F.; Santoro, M. G.

10.1101/2021.04.12.439201 — microbiology — Posted on 2022-01-04

3663 Hypothalamic GABRA5-positive Neurons Control Obesity via Astrocytic GABA

Sa, M.; Yoo, E.-S.; Koh, W.; Park, M. G.; Jang, H.-J.; Yang, Y. R.; Lim, J.; Won, W.; Kwon, J.; Bhalla, M.; An, H.; Seong, Y.; Lee, S. E.; Park, K. D.; Suh, P.-G.; Sohn, J.-W.; Lee, C. J. J.

10.1101/2021.11.07.467613 — neuroscience — Posted on 2022-01-04

3664 Reactive astrocytes promote proteostasis in Huntington disease through the JAK2-STAT3 pathway

Abjean, L.; Ben Haim, L.; Riquelme-Perez, M.; Gipchtein, P.; Derbois, C.; Palomares, M.-A.; Petit, F.; Herard, A.-S.; Gaillard, M.-C.; Guillermier, M.; Gaudin-Guerif, M.; Auregan, G.; Sagar, N.; Hery, C.; Dufour, N.; Robil, N.; Kabani, M.; Melki, R.; De la grange, P.; Bemelmans, A.; Bonvento, G.; Deleuze, J.-F.; Hantraye, P.; Flament, J.; Bonnet, E.; Brohard, S.; Olaso, R.; Brouillet, E.; Carrillo-de Sauvage, M.; Escartin, C.

10.1101/2021.04.29.441924 — neuroscience — Posted on 2022-01-04

3665 Oxytocin modulates social brain network correlations in resting and task state

Wu, Q.; Huang, Q.; Liu, C.; Wu, H.

10.1101/2021.12.30.474596 — neuroscience — Posted on 2022-01-04

3666 Weak catch bonds make strong networks

Mulla, Y.; Avellaneda, M. J.; Roland, A.; Baldauf, L.; Jung, W.; Kim, T.; Tans, S. J.; Koenderink, G.

10.1101/2020.07.27.219618 — biophysics — Posted on 2022-01-04

3667 Characterization of divalent cation interactions with AASTY native nanodiscs

Timcenko, M.; Autzen, A. A. A.; Autzen, H. E.

10.1101/2021.10.07.463511 — biochemistry — Posted on 2022-01-04

3668 Habit formation viewed as structural change in the behavioral network

Yamada, K.; Toda, K.

10.1101/2021.07.29.454400 — animal behavior and cognition — Posted on 2022-01-04

3669 Revealing genomic changes responsible for cannabinoid receptor loss in parrots: mechanism and functional effects

Divin, D.; Gomez Samblas, M.; Kuttiyarthu Veetil, N.; Voukali, E.; Swiderska, Z.; Krajzingrova, T.; Tesicky, M.; Benes, V.; Elleder, D.; Bartos, O.; Vinkler, M.

10.1101/2022.01.03.474805 — genomics — Posted on 2022-01-04

3670 A positive correlation between GC content and growth temperature in prokaryotes

Hu, E.-Z.; Lan, X.-R.; Liu, Z.-L.; Gao, J.; Niu, D.-K.

10.1101/2021.04.27.441598 — genomics — Posted on 2022-01-04

3671 Atg11 promotes Kar9-mediated alignment of the mitotic spindle

Reza, M. H.; Verma, J.; Chowdhury, R.; Manjithaya, R.; Sanyal, K.

10.1101/2021.12.15.472744 — genetics — Posted on 2022-01-04

3672 The dopamine dip amplitude is a quantitative measure of disappointment

Shikano, Y.; Yagishita, S.; Tanaka, K. F.; Takata, N.

10.1101/2021.07.23.453499 — neuroscience — Posted on 2022-01-04

3673 An ultra-sensitive and easy-to-use multiplexed single-cell proteomic analysis

Gu, L.; Li, Z. Y.; Wang, Q. Q.; Zhang, H. P.; Sun, Y. D.; Li, C.; Wang, H.

10.1101/2022.01.02.474723 — systems biology — Posted on 2022-01-04

3674 Somatic genetics analysis of sleep in adult mice

Liu, Q.; Wang, F.; Wang, G.; Li, Q.; Xu, J.; Zhao, S.; Zhou, R.; Chen, Z.; Jiang, W.; Gao, X.; Zhou, S.; Chen, Z.; Sun, Q.; Ma, C.; Chen, L.; Shi, B.; Guo, Y.; Wang, H.; Wang, X.; Li, H.; Cai, T.; Wang, Y.; Chen, Z.

10.1101/2021.05.05.442860 — neuroscience — Posted on 2022-01-03

3675 Effects of α-crystallin gene knockout on zebrafish lens development

Posner, M.; Murray, K. L.; Andrew, B.; Brdicka, S.; Butterbaugh-Roberts, A.; Franklin, K.; Hussen, A.; Kaye, T.; Kepp, E.; McDonald, M. S.; Snodgrass, T.; Zientek, K.; David, L. L.

10.1101/2021.12.22.473921 — developmental biology — Posted on 2022-01-03

3676 Akkermansia Muciniphila induces chronic extramedullary hematopoiesis through cooperative IL-1R and TLR signals

Wang, Y.; Morishima, T.; Sezaki, M.; Nakato, G.; Fukuda, S.; Li, Y.; Takizawa, H.

10.1101/2022.01.03.474846 — microbiology — Posted on 2022-01-03

3677 15N metabolic labeling quantification workflow in Arabidopsis using Protein Prospector

Shrestha, R.; Reyes, A. V.; Baker, P. R.; Wang, Z.-Y.; Chalkley, R. J.; Xu, S.-L.

10.1101/2021.11.30.470624 — plant biology — Posted on 2022-01-03

3678 Towards Generalizable Predictions for the Effects of Mutations on G-Protein Coupled Receptor Expression

Kuntz, C. P.; Woods, H.; McKee, A. G.; Zelt, N. B.; Mendenhall, J. L.; Meiler, J.; Schlebach, J. P.

10.1101/2021.12.28.474371 — biophysics — Posted on 2022-01-03

3679 Energetics of a protein disorder-order transition in small molecule recognition

Mendoza-Martinez, C.; Papadourakis, M.; llabres, s.; Gupta, A. A.; Barlow, P. N.; Michel, J.

10.1101/2021.08.05.454052 — biophysics — Posted on 2022-01-03

3680 P-TEFb is degraded by Siah1/2 in quiescent cells

Huang, F.; Feng, Y.; Peterlin, B. M.; Fujinaga, K.

10.1101/2021.12.30.474394 — biochemistry — Posted on 2022-01-03

3681 Reconstruction of nitrogenase predecessors suggests origin from maturase-like proteins

Garcia, A. K.; Kolaczkowski, B.; Kacar, B.

10.1101/2021.07.07.451390 — evolutionary biology — Posted on 2022-01-03

3682 Analysis of caspase-mediated suppression of the cGAS/STING pathway in Kaposi's sarcoma associated herpesvirus lytic infection reveals a dramatic cellular heterogeneity in type I interferon responses

Tabtieng, T.; Lent, R. C.; Monago Sanchez, A.; Gaglia, M. M.

10.1101/2021.05.03.442439 — microbiology — Posted on 2022-01-03

3683 Insightful inference compensates for distorted perception

Mihali, A. L.; Broeker, M. D.; Horga, G.

10.1101/2021.11.13.468497 — neuroscience — Posted on 2022-01-03

3684 Impaired endogenous neurosteroid signaling contributes to behavioral deficits associated with chronic stress

Walton, N. L.; Antonoudiou, P.; Barros, L.; DiLeo, A.; Gabby, J.; Howard, S.; Paracha, R.; Sanchez, E. J.; Weiss, G. L.; Kong, D.; Maguire, J.

10.1101/2021.12.30.474579 — neuroscience — Posted on 2022-01-03

3685 Neuromodulators generate multiple context-relevant behaviors in a recurrent neural network by shifting activity hypertubes

Tsuda, B.; Pate, S. C.; Tye, K. M.; Siegelmann, H. T.; Sejnowski, T. J.

10.1101/2021.05.31.446462 — neuroscience — Posted on 2022-01-03

3686 An in vivo pig model for testing novel PET radioligands targeting cerebral protein aggregates

Raval, N. R.; Nasser, A.; Madsen, C. A.; Beschorner, N.; Beaman, E. E.; Juhl, M.; Lehel, S.; Palner, M.; Svarer, C.; Plaven-Sigray, P.; Jorgensen, L. M.; Knudsen, G. M.

10.1101/2021.12.31.473908 — neuroscience — Posted on 2022-01-03

3687 Efficient and stochastic mouse action switching during probabilistic decision making

Beron, C. C.; Neufeld, S. Q.; Linderman, S. W.; Sabatini, B. L.

10.1101/2021.05.13.444094 — neuroscience — Posted on 2022-01-03

3688 Elementary vectors and autocatalytic sets for computational models of cellular growth

Müller, S.; Szeliova, D.; Zanghellini, J.

10.1101/2021.10.31.466640 — systems biology — Posted on 2022-01-03

3689 An ultra-sensitive and easy-to-use multiplexed single-cell proteomic analysis

Gu, L.; Li, Z. Y.; Wang, Q. Q.; Zhang, H. P.; Li, X. M.; Li, J. Q.; Sun, Y. D.; Li, C.; Wang, H.

10.1101/2022.01.02.474723 — systems biology — Posted on 2022-01-03

3690 Maize brace root mechanics vary by whorl, genotype, and reproductive stage

Hostetler, A. N.; Erndwein, L.; Ganji, E.; Reneau, J. W.; Killian, M. L.; Sparks, E. E.

10.1101/547794 — plant biology — Posted on 2022-01-03

3691 Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels

Cecon, E.; Fernandois, D.; Renault, N.; Coelho, C. F. F.; Wenzel, J.; Bedart, C.; Izabelle, C.; Gallet, S.; Le Poder, S.; Klonjkowski, B.; Schwaninger, M.; PREVOT, V.; Dam, J.; Jockers, R.

10.1101/2021.12.30.474561 — pharmacology and toxicology — Posted on 2022-01-03

3692 BRPF3 knockdown or inhibition moderately reverses olaparib resistance in high grade serous ovarian carcinoma

Bitler, B. G.; Yamamoto, T. M.; McMellen, A.; Kim, H.; Watson, Z. L.

10.1101/2021.12.21.473688 — cancer biology — Posted on 2022-01-03

3693 An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene

Azman, M. S.; Dodel, M.; Capraro, F.; Faraway, R.; Dermit, M.; Fan, W.; Ule, J.; Mardakheh, F. K.

10.1101/2021.12.16.472890 — cancer biology — Posted on 2022-01-03

3694 Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine arm of its donor substrate and weakly binds the acyl carrier protein

Dhembla, C.; Yadav, U.; Kundu, S.; Sundd, M.

10.1101/2022.01.03.474776 — biophysics — Posted on 2022-01-03

3695 Profiling of the drug resistance of thousands of Src tyrosine kinase mutants uncovers a regulatory network that couples autoinhibition to the dynamics of the catalytic domain

Chakraborty, S.; Ahler, E.; Simon, J.; Fang, L.; Potter, Z.; Sitko, K.; Stephany, J.; Guttman, M.; Fowler, D.; Maly, D. J.

10.1101/2021.12.05.471322 — biochemistry — Posted on 2022-01-03

3696 3D Reconstruction of Bird Flight Trajectories Using a Single Video Camera

Srinivasan, M. V.; Vo, H. D.; Schiffner, I.

10.1101/340232 — animal behavior and cognition — Posted on 2022-01-03

3697 Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2

Reynisdottir, T.; Anderson, K.; Boukas, L.; Bjornsson, H.

10.1101/2022.01.03.474770 — genetics — Posted on 2022-01-03

3698 Wetland loss in the Neembucu Wetlands Complex, Paraguay, using remote sensing

O'Leary, F.

10.1101/2022.01.03.474818 — ecology — Posted on 2022-01-03

3699 Mito-FUNCAT-FACS reveals cellular heterogeneity in mitochondrial translation

Kimura, Y.; Saito, H.; Osaki, T.; Ikegami, Y.; Wakigawa, T.; Ikeuchi, Y.; Iwasaki, S.

10.1101/2022.01.03.474764 — molecular biology — Posted on 2022-01-03

3700 Cell type specific IL-27p28 (IL-30) deletion uncovers an unexpected pro-inflammatory property of IL-30 in autoimmune inflammation

Kim, D.; Kim, S.; Yin, Z.; Min, B.

10.1101/2022.01.03.474823 — immunology — Posted on 2022-01-03

3701 Volatile anesthetics inhibit presynaptic cGMP signaling to depress presynaptic excitability in rat hippocampal neurons

Speigel, I. A.; Osman, V.; Hemmings, H. C.

10.1101/2022.01.03.474845 — neuroscience — Posted on 2022-01-03

3702 Seed-competent tau monomer initiates pathology in PS19 tauopathy mice

Mirbaha, H.; Chen, D.; Mullapudi, V.; Terpack, S. J. E.; White, C. L.; Joachimiak, L. A.; Diamond, M. I.

10.1101/2022.01.03.474806 — neuroscience — Posted on 2022-01-03

3703 Integrated Autolysis, DNA Hydrolysis and Precipitation Enables an Improved Bioprocess for Q-Griffithsin, a Broad-Spectrum Antiviral and Clinical-Stage anti-COVID-19 Candidate

Decker, J. S.; Menacho-Melgar, R.; Lynch, M. D.

10.1101/2021.12.30.474602 — synthetic biology — Posted on 2022-01-03

3704 Controlled exchange of protein and nucleic acid signals from and between synthetic minimal cells

Heili, J. M.; Stokes, K.; Gaut, N. J.; Deich, C.; Gomez-Garcia, J.; Cash, B.; Pawlak, M. R.; Engelhart, A. E.; Adamala, K. P.

10.1101/2022.01.03.474826 — synthetic biology — Posted on 2022-01-03

3705 Cellular and gene expression patterns associated with root bifurcation in Selaginella

Beeckman, T.; Fang, T.; Motte, H.; Parizot, B.; Smet, W.; Yang, X.; Walker, L.; Njo, M.; Bassel, G.

10.1101/2022.01.03.474808 — plant biology — Posted on 2022-01-03

3706 Demonstration of a common DPhe7 to DNal(2')7 peptide ligand antagonist switch for the melanocortin-3 and melanocortin-4 receptors identifies systematic mischaracterization of the pharmacological properties of melanocortin peptides

Gimenez, L. E.; Noblin, T. A.; Williams, S. Y.; Mullick Bagchi, S.; Ji, R.-L.; Tao, Y.-X.; Jeppesen, C. B.; Conde-Frieboes, K. W.; Sawyer, T. K.; Grieco, P.; Cone, R. D.

10.1101/2022.01.03.474807 — pharmacology and toxicology — Posted on 2022-01-03

3707 Serum metabolomic analysis of men on a low-carbohydrate diet for biochemically recurrent prostate cancer reveal the potential role of ketogenesis to slow tumor growth: A secondary analysis of the CAPS2 diet trial

Chi, J.-T. A.; Lin, P.-H.; Tolstikov, V.; Howard, L.; Chen, E. Y.; Bussberg, V.; Greenwood, B.; Narain, N. R.; Kiebish, M. A.; Freedland, S.

10.1101/2021.12.29.474437 — cancer biology — Posted on 2022-01-03

3708 Hydrodynamics of spike proteins dictate a transport-affinity competition for SARS-CoV-2 and other enveloped viruses

Moreno, N.; Moreno-Chaparro, D.; Balboa Usabiaga, F.; Ellero, M.

10.1101/2022.01.03.474721 — biophysics — Posted on 2022-01-03

3709 Directed evolution of angiotensin-converting enzyme 2 (ACE2) variants with enhanced peptidase activity profiles for novel therapeutic applications

Heinzelman, P.; Romero, P. A.

10.1101/2022.01.03.474817 — biochemistry — Posted on 2022-01-03

3710 Splicing QTL analysis focusing on coding sequences reveals pathogenicity of disease susceptibility loci.

Yamaguchi, K.; Ishigaki, K.; Suzuki, A.; Tsuchida, Y.; Tsuchiya, H.; Sumitomo, S.; Nagafuchi, Y.; Miya, F.; Tsunoda, T.; Hirofumi, S.; Fujio, K.; Yamamoto, K.; Kochi, Y.

10.1101/2021.12.30.474578 — genetics — Posted on 2022-01-03

3711 Increasing adult density compromises anti-bacterial defense in Drosophila melanogaster

Das, P. N.; Basu, A. K.; Prasad, N. G.

10.1101/2022.01.02.474745 — evolutionary biology — Posted on 2022-01-03

3712 A triad of kicknet sampling, eDNA metabarcoding, and predictive modeling to assess aquatic macroinvertebrate biodiversity

Keck, F.; Hürlemann, S.; Locher, N.; Stamm, C.; Deiner, K.; Altermatt, F.

10.1101/2022.01.03.474789 — ecology — Posted on 2022-01-03

3713 Cell culture model system utilizing engineered A549 cells to express high levels of ACE2 and TMPRSS2 for investigating SARS-CoV-2 infection and antivirals

Chang, C.-W.; Parsi, K. M.; Somasundaran, M.; Vanderleeden, E.; Cruz, J.; Cousineau, A.; Liu, P.; Li, Q.; Wang, Y.; Maehr, R.; Wang, J. P.; Finberg, R. W.

10.1101/2021.12.31.474593 — cell biology — Posted on 2022-01-03

3714 A dual-receptor mechanism between integrins and ACE2 widens SARS-CoV-2 tissue tropism

Nader, D.; Gressett, T. E.; Hossen, M. L.; Chapagain, P. P.; Kerrigan, S. W.; Bix, G.

10.1101/2022.01.02.474028 — cell biology — Posted on 2022-01-03

3715 The SARS-CoV-2 variant, Omicron, shows rapid replication in human primary nasal epithelial cultures and efficiently uses the endosomal route of entry.

Peacock, T. P.; Brown, J. C.; Zhou, J.; Thakur, N.; Newman, J.; Kugathasan, R.; Sukhova, K.; Kaforou, M.; Bailey, D.; Barclay, W. S.

10.1101/2021.12.31.474653 — microbiology — Posted on 2022-01-03

3716 In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolate

Touret, F.; Baronti, C.; Bouzidi, H. S.; de Lamballerie, X.

10.1101/2022.01.01.474639 — microbiology — Posted on 2022-01-03

3717 Omicron variant escapes therapeutic mAbs contrary to eight prior main VOC

Boschi, C.; Colson, P.; Bancod, A.; Moal, V.; La Scola, B.

10.1101/2022.01.03.474769 — microbiology — Posted on 2022-01-03

3718 An in vitro and in vivo approach for the isolation of Omicron variant from human clinical specimens

Yadav, P. D.; Gupta, N.; Potdar, V.; Mohandas, S.; Sahay, R. R.; Sarkale, P.; Shete, A. M.; Razdan, A.; Patil, D. Y.; Nyayanit, D. A.; Joshi, Y.; Patil, S.; Majumdar, T.; Dighe, H.; Malhotra, B.; Shastri, J.; Abraham, P.

10.1101/2022.01.02.474750 — microbiology — Posted on 2022-01-03

3719 Understanding drivers of phylogenetic clustering and terminal branch lengths distribution in epidemics of Mycobacterium tuberculosis

Menardo, F.

10.1101/2022.01.03.474767 — microbiology — Posted on 2022-01-03

3720 In planta transcriptomics reveals conflicts between pattern-triggered immunity and the AlgU sigma factor regulon

Wang, H.; Lovelace, A.; Smith, A.; Kvitko, B. H.

10.1101/2022.01.03.474781 — microbiology — Posted on 2022-01-03

3721 Duplication and overexpression of the genes encoding a beta 1,3-glucan synthase confer the intrinsic resistance to echinocandin in Mucor circinelloides

Lee, S. C.; Garcia, A.; Huh, E. Y.

10.1101/2022.01.03.474814 — microbiology — Posted on 2022-01-03

3722 RG203KR mutations in SARS-CoV-2 Nucleocapsid: Assessing the impact using Virus-like particle model system

Raheja, H.; Das, S.; Banerjee, A.; P, D.; C, D.; Mukhopadhyay, D.; Ramachandra, S. G.; Das, S.

10.1101/2022.01.02.473343 — microbiology — Posted on 2022-01-03

3723 Nonself Mutations in the Spike Protein Suggest an Increase in the Antigenicity and a Decrease in the Virulence of the Omicron Variant of SARS-CoV-2

Otaki, J. M.; Nakasone, W.; Nakamura, M.

10.1101/2021.12.30.474613 — immunology — Posted on 2022-01-03

3724 Phosphoantigens are Molecular Glues that Promote Butyrophilin 3A1/2A1 Association Leading to Vγ9Vδ2 T Cell Activation

Yuan, L.; Ma, X.; Yang, Y.; Li, X.; Ma, W.; Yang, H.; Huang, J.-W.; Xue, J.; Yi, S.; Zhang, M.; Cai, N.; Ding, Q.; Li, L.; Duan, J.; Malwal, S.; Chen, C.-C.; Oldfield, E.; Guo, R.-T.; Zhang, Y.

10.1101/2022.01.02.474068 — immunology — Posted on 2022-01-03

3725 SARS-CoV-2 entry sites are present in all structural elements of the human glossopharyngeal and vagal nerves: clinical implications

Mezey, E.; Vitale-Cross, L.; Szalayova, I.; Scoggins, A.; Palkovits, M.

10.1101/2021.12.30.474580 — neuroscience — Posted on 2022-01-03

3726 Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin's hunger-suppressing effects

Heyward, F. D.; Liu, N.; Jacobs, C.; Ivison, R.; Machado, N.; Uner, A.; Srinivasan, H.; Patel, S.; Gulko, A.; Sermersheim, T.; Orkin, S. H.; Tsai, L.; Rosen, E. D.

10.1101/2022.01.03.474708 — neuroscience — Posted on 2022-01-03

3727 Essential regulatory functions of CaMKII T286 phosphorylation in LTP and two distinct forms of LTD

Bayer, K. U.; Cook, S. G.; Rumian, N. L.

10.1101/2022.01.03.474759 — neuroscience — Posted on 2022-01-03

3728 Long-term dynamic changes of NMDA receptors following an excitotoxic challenge

Granzotto, A.; d'Aurora, M.; Bomba, M.; Gatta, V.; Onofrj, M.; Sensi, S. L.

10.1101/2022.01.03.474836 — neuroscience — Posted on 2022-01-03

3729 Engineering Protein Activity into Off-the-Shelf DNA Devices

Sekhon, H.; Loh, S. N.

10.1101/2022.01.03.474821 — synthetic biology — Posted on 2022-01-03

3730 Robust expansion of phylogeny for fast-growing genome sequence data

Ye, Y.; Shum, M.; Tsui, J.; Yu, G.; Smith, D.; Zhu, H.; Wu, J.; Guan, Y.; Lam, T. T.-Y.

10.1101/2021.12.30.474610 — bioinformatics — Posted on 2022-01-03

3731 Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR

Stevers, L. M.; Wolter, M.; Carlile, G.; Macdonald, D.; Richard, L.; Gielkens, F.; Thomas, D.; Chakka, S. K.; Peterson, M. L.; Thomas, H.; Brunsveld, L.; Ottmann, C.

10.1101/2022.01.03.473871 — biochemistry — Posted on 2022-01-03

3732 Cystic fibrosis patient-derived bronchial organoids unveil druggable pathways against Mycobacterium abscessus infection.

Leon Icaza, S. A.; Bagayoko, S.; Iakobachvili, N.; Ferrand, C.; Aydogan, T.; Bernard, C.; Sanchez Dafun, A.; Murris-Espin, M.; Mazieres, J.; Bordignon, P. J.; Mazeres, S.; Bernes Lasserre, P.; Rame, V.; Lagarde, J.-M.; Marcoux, J.; Bousquet, M. P.; Chalut, C.; Guilhot, C.; Clevers, H.; Peters, P. J.; Molle, V.; Lugo-Villarino, G.; Cam, K.; Berry, L.; Meunier, E.; Cougoule, C.

10.1101/2022.01.03.474765 — cell biology — Posted on 2022-01-03

3733 Reduced Pathogenicity of the SARS-CoV-2 Omicron Variant in Hamsters

McMahan, K.; Giffin, V.; Tostanoski, L.; Chung, B.; Siamatu, M.; Suthar, M.; Halfmann, P.; Kawaoka, Y.; Piedra-Mora, C.; Martinot, A.; Kar, S.; Andersen, H.; Lewis, M. G.; Barouch, D. H.

10.1101/2022.01.02.474743 — microbiology — Posted on 2022-01-03

3734 Analysis of SARS-CoV-2 Omicron Neutralization Data up to 2021-12-22

Netzl, A.; Tureli, S.; LeGresley, E.; Mühlemann, B.; Wilks, S. H.; Smith, D. J.

10.1101/2021.12.31.474032 — immunology — Posted on 2022-01-03

3735 Heat-Dependent Hairpin Melting Drives TRPV1 Opening

Wang, G.

10.1101/2022.01.02.474701 — biophysics — Posted on 2022-01-03

3736 Design Maps of TRPM8 as a Thermometer for Cold Detection

Wang, G.

10.1101/2022.01.02.474742 — biophysics — Posted on 2022-01-03

3737 Distinct roles of core autophagy-related genes (ATGs) in zebrafish definitive hematopoiesis

CHEN, X.-K.; YI, Z.-N.; LAU, J. J.-Y.; MA, A. C.-H.

10.1101/2022.01.03.474766 — developmental biology — Posted on 2022-01-03

3738 mBeRFP, a versatile fluorescent tool to enhance multichannel live imaging and its applications

Martin, E.; Suzanne, M.

10.1101/2022.01.03.474820 — developmental biology — Posted on 2022-01-03

3739 Evaluation of lamin A/C mechanotransduction under different surface topography in LMNA related muscular dystrophy.

Dutta, S.; Vasudevan, M.; Thangamuniyandi, M.

10.1101/2022.01.03.474777 — cell biology — Posted on 2022-01-03

3740 Microtubules restrict F-actin to the immune synapse via GEF-H1 to maintain polarity in lymphocytes

Pineau, J.; Pinon, L.; Mesdjian, O.; Fattaccioli, J.; Lennon Dumenil, A.-M.; Pierobon, P.

10.1101/2022.01.03.473915 — cell biology — Posted on 2022-01-03

3741 Vps68 cooperates with ESCRT-III in intraluminal vesicle formation

Alsleben, S.; Kölling, R.

10.1101/2022.01.03.474785 — molecular biology — Posted on 2022-01-03

3742 ClusTrast: a short read de novo transcript isoform assembler guided by clustered contigs

Westrin, K. J.; Kretzschmar, W. W.; Emanuelsson, O.

10.1101/2022.01.02.473666 — bioinformatics — Posted on 2022-01-03

3743 Urban-adapted mammal species have more known pathogens

Albery, G. F.; Carlson, C. J.; Cohen, L. E.; Eskew, E. A.; Gibb, R.; Ryan, S. J.; Sweeny, A. R.; Becker, D. J.

10.1101/2021.01.02.425084 — ecology — Posted on 2022-01-03

3744 A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

Wang, K.; Jia, Z.; Bao, L.; Wang, L.; Cao, L.; Chi, H.; Hu, Y.; Li, Q.; Jiang, Y.; Zhu, Q.; Deng, Y.; Liu, P.; Wang, N.; Wang, L.; Liu, M.; Li, Y.; Zhu, B.; Fan, K.; Fu, W.; Yang, P.; Pei, X.; Cui, Z.; Qin, L.; Ge, P.; Wu, J.; Liu, S.; Chen, Y.; Huang, W.; Qin, C.; Wang, Y.; Qin, C.; Wang, X.

10.1101/2021.12.24.474084 — microbiology — Posted on 2022-01-03

3745 High-resolution screening for marine prokaryotic and eukaryotic taxa with selective preference for PE and PET surfaces

Marsay, K.; Koucherov, Y.; Davidov, K.; Iankelevich Kounio, E.; Itzahri, S.; Salmon-Divon, M.; Oren, M.

10.1101/2021.12.26.474179 — microbiology — Posted on 2022-01-03

3746 An interactome landscape of SARS-CoV-2 virus-human protein-protein interactions by protein sequence-based multi-label classifiers

Lee, H.-J.

10.1101/2021.11.07.467640 — systems biology — Posted on 2022-01-03

3747 Parallel evolution of urban-rural clines in melanism in a widespread mammal

Cosentino, B. J.; Gibbs, J.

10.1101/2021.09.08.459478 — evolutionary biology — Posted on 2022-01-03

3748 Coupled protein quality control during nonsense mediated mRNA decay

Inglis, A. J.; Guna, A.; Merchan, A. G.; Pal, A.; Esantsi, T. K.; Keys, H. R.; Frenkel, E. M.; Oania, R.; Weissman, J. S.; Voorhees, R. M.

10.1101/2021.12.22.473893 — molecular biology — Posted on 2022-01-03

3749 Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized mice

Sun, R.; Zhao, Z.; Fu, C.; Wang, Y.; Guo, Z.; Zhang, C.; Liu, L.; Zhang, C.; Shu, C.; He, J.; Hua, S.; Gao, Y.; Hu, Z.

10.1101/2021.11.05.466755 — immunology — Posted on 2022-01-03

3750 Normalizing the brain connectome for communication through synchronization

Petkoski, S.; Jirsa, V.

10.1101/2020.12.02.408518 — neuroscience — Posted on 2022-01-03

3751 Dynamic evolution of small signaling peptide compensation in plant stem cell control

Kwon, C.-T.; Tang, L.; Wang, X.; Gentile, I.; Hendelman, A.; Robitaille, G.; Van Eck, J.; Xu, C.; Lippman, Z.

10.1101/2022.01.03.474791 — plant biology — Posted on 2022-01-03

3752 Immunosuppression broadens evolutionary pathways to treatment failure during Acinetobacter baumannii pneumonia

Huo, W.; Busch, L. M.; Hernandez-Bird, J.; Hamami, E.; Marshall, C. W.; Geisinger, E.; Cooper, V. S.; van Opijnen, T.; Rosch, J.; Isberg, R. R.

10.1101/2021.04.07.438861 — microbiology — Posted on 2022-01-03

3753 Human red blood cells express the RNA sensor TLR7 and bind viral RNA

Lam, L. M.; Clements, R. L.; Eckart, K. A.; Weisman, A. R.; Vaughan, A. E.; Yehya, N.; Meyer, N. J.; Jurado, K. A.; Mangalmurti, N. S.

10.1101/2022.01.01.474694 — immunology — Posted on 2022-01-03

3754 scTenifoldKnk: an efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation

Osorio, D.; Zhong, Y.; Li, G.; Xu, Q.; Yang, Y.; Tian, Y.; Chapkin, R. S.; Huang, J. Z.; Cai, J. J.

10.1101/2021.03.22.436484 — bioinformatics — Posted on 2022-01-03

3755 DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics

Robertson, G. L.; Riffle, S.; Patel, M.; Marshall, A.; Beasley, H.; Garza-Lopez, E.; Shao, J.; Vue, Z.; Hinton, A.; Mears, J.; Gama, V.

10.1101/2021.12.31.474637 — cell biology — Posted on 2022-01-03

3756 CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells

Conery, A.; Bommi-Reddy, A.; Park-Chouinard, S.; Mayhew, D. N.; Terzo, E.; Hingway, A.; Steinbaugh, M. J.; Wilson, J. E.; Sims, R. J.

10.1101/2021.12.26.474204 — cancer biology — Posted on 2022-01-03

3757 Kinetic isotope tracing of glycerol and de novo proteogenic amino acids in Human Lung Carcinoma cells using glucose

Akram, S.; Thakur, J.; Shree, M.; Masakapalli, S. K.; Nanda, R. K.

10.1101/2020.10.28.358432 — biochemistry — Posted on 2022-01-03

3758 The First High-Quality Genome Assembly and Data Analysis of the Malaysian mahseer (Tor tambroides)

Lau, M. M. L.; LIM, L. W. K.; Chung, H.-H.; Gan, H. M.

10.1101/2022.01.02.474749 — genomics — Posted on 2022-01-03

3759 Retrieval context determines whether event boundaries impair or enhance temporal order memory

Wen, T.; Egner, T.

10.1101/2022.01.02.474709 — neuroscience — Posted on 2022-01-03

3760 Polymer brush bilayers under stationary shear motion at linear response regime: A theoretical approach

Edwards, M.

10.1101/565796 — biophysics — Posted on 2022-01-03

3761 Single-cell RNA-Seq analysis reveals dual sensing of HIV-1 in blood Axl+ dendritic cells

Brouiller, F.; Nadalin, F.; Aït-Mohamed, O.; Bonte, P.-E.; Delaugerre, C.; Lelievre, J.-D.; Ginhoux, F.; RUFFIN, N.; BENAROCH, P.

10.1101/2022.01.03.474732 — immunology — Posted on 2022-01-03

3762 Cancer metabolic subtypes and their association with molecular and clinical features

Moiso, E.; Provero, P.

10.1101/2021.12.16.472974 — cancer biology — Posted on 2022-01-03

3763 Supergene formation: evidence for recombination suppression among multiple functional loci within inversions.

Jay, P.; Leroy, M.; Le Poul, Y.; Whibley, A.; Arias, M.; Chouteau, M.; Joron, M.

10.1101/2021.12.16.472922 — evolutionary biology — Posted on 2022-01-03

3764 How many giraffes are there? A comparison of abundance estimators at Ongava Game Reserve, Namibia

Bonenfant, C.; Stratford, K.; Periquet, S.

10.1101/2021.09.28.459593 — ecology — Posted on 2022-01-03

3765 Signal neutrality, scalar property, and collapsing boundaries as consequences of a learned multi-time scale strategy

Manneschi, L.; Gigante, G.; Vasilaki, E.; Del Giudice, P.

10.1101/2021.09.01.458481 — neuroscience — Posted on 2022-01-03

3766 The adolescent pattern of sleep spindle development revealed by HD-EEG polysomnography

Bocskai, G.; Potari, A.; Gombos, F.; Kovacs, I.

10.1101/2021.12.20.473516 — neuroscience — Posted on 2022-01-03

3767 Effector-mediated subversion of proteasome activator (PA)28αβ enhances lysosomal targeting of Legionella pneumophila within cytokine-activated macrophages

Ngwaga, T.; Chauhan, D.; Salberg, A. G.; Shames, S. R.

10.1101/2021.12.27.473672 — microbiology — Posted on 2022-01-03

3768 Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains

Roelle, S. M.; Shukla, N.; Pham, A. T.; Bruchez, A. M.; Matreyek, K. A.

10.1101/2021.12.25.474149 — microbiology — Posted on 2022-01-03

3769 Nucleus size and its effect on the chromatin structure in living cells.

Efremov, A. K.; Hovan, L.; Yan, J.

10.1101/2021.07.27.453925 — biophysics — Posted on 2022-01-03

3770 Avian haemosporidians (Plasmodium and Haemoproteus) status in selected bird groups (Old world Flycatchers, Warblers, Babblers, and Thrushes) of India and their phylogenetic relationships with other lineages of the world

Sharma, V.; Singh, A.; Dixit, R.; Tripathi, N. K.; Singh, B.; Sharma, V.; Sharma, C. P.; Mohan, D.; GUPTA, S. K.

10.1101/2021.09.27.461904 — genetics — Posted on 2022-01-03

3771 Single particle-resolution fluorescence microscopy of nanoplastics

Nguyen, B.; Tufenkji, N.

10.1101/2020.08.25.267443 — ecology — Posted on 2022-01-03

3772 Properties and computational consequences of fast dendritic spikes during natural behavior

Destexhe, A.; Mehta, M.

10.1101/2021.12.27.474234 — neuroscience — Posted on 2022-01-03

3773 Augmenting Flexibility: Mutual Inhibition Between Inhibitory Neurons Expands Functional Diversity

Liu, B.; White, A. J.; Lo, C.-C.

10.1101/2020.11.08.371179 — neuroscience — Posted on 2022-01-03

3774 Water levels primarily drive variation in photosynthesis and nutrient use of scrub Red Mangroves in the southeastern Florida Everglades

Hogan, J. A.; Castaneda-Moya, E.; Lamb-Wotton, L.; Troxler, T.; Baraloto, C.

10.1101/2021.01.27.428494 — plant biology — Posted on 2022-01-03

3775 Single-cell analysis of microglial transcriptomic diversity in subarachnoid hemorrhage

Chen, J.; Sun, L.; Lyu, H.; Zheng, Z.; Lai, H.; Wang, Y.; Luo, Y.; Lu, G.; Chan, W. Y.; Zhang, Y.; Chen, X.; Li, Z.; Ko, H.; Wong, K. C. G.

10.1101/2021.12.27.474223 — neuroscience — Posted on 2022-01-02

3776 Uncovering a neural circuit controlling adult quiescent neural stem cell activation in the subventricular zone

Naffaa, M. M.; Khan, R. R.; Kuo, C. T.; Yin, H. H.

10.1101/2021.12.27.474262 — neuroscience — Posted on 2022-01-02

3777 Connectional architecture of the prefrontal cortex in the marmoset brain

Watakabe, A.; Skibbe, H.; Nakae, K.; Abe, H.; Ichinohe, N.; Wang, J.; Takaji, M.; Mizukami, H.; Woodward, A.; Gong, R.; Hata, J.; Okano, H.; Ishii, S.; Yamamori, T.

10.1101/2021.12.26.474213 — neuroscience — Posted on 2022-01-02

3778 Asymmetric habitat isolation and sexual isolation predicted by the cost of migration and hybridization generate novel signatures of reinforcing selection

Zhang, L.; Hood, G. R.; Ott, J. R.; Egan, S. P.

10.1101/2022.01.02.474698 — evolutionary biology — Posted on 2022-01-02

3779 Optogenetic Manipulation of Cell Migration with High Spatiotemporal Resolution Using Lattice Lightsheet Microscopy

Tang, W.-C.; Liu, Y.-T.; Yeh, C.-H.; Lin, Y.-L.; Lin, Y.-C.; Hsu, T.-L.; Gao, L.; Chang, S.-W.; Chen, P.; Chen, B.-C.

10.1101/2022.01.02.474058 — cell biology — Posted on 2022-01-02

3780 A wMel Wolbachia variant in Aedes aegypti from field-collected Drosophila melanogaster with increased phenotypic stability under heat stress

Gu, X.; Ross, P. A.; Rodriguez-Andres, J.; Robinson, K. L.; Yang, Q.; Lau, M.-J.; Hoffmann, A. A.

10.1101/2022.01.02.474744 — microbiology — Posted on 2022-01-02

3781 Neural correlates of individual differences in aversion to risk and choice inconsistency

Jaquerod, M. E.; Lintas, A.; Gratton, G.; Fabiani, M.; Low, K. A.; Tobler, P. N.; Villa, A. E. P.

10.1101/2021.05.10.443362 — neuroscience — Posted on 2022-01-02

3782 The Layer 7 Cortical Interface: A Scalable and Minimally Invasive Brain-Computer Interface Platform

Ho, E.; Hettick, M.; Papageorgiou, D.; Poole, A. J.; Monge, M.; Vomero, M.; Gelman, K. R.; Hanson, T.; Tolosa, V.; Mager, M.; Rapoport, B. I.

10.1101/2022.01.02.474656 — neuroscience — Posted on 2022-01-02

3783 Intestinal Mucin Is a Chaperone of Multivalent Copper

Reznik, N.; Gallo, A. D.; Rush, K. W.; Javitt, G.; Fridmann-Sirkis, Y.; Ilani, T.; Nairner, N. A.; Chacon, K.; Franz, K. J.; Fass, D.

10.1101/2022.01.02.474741 — biochemistry — Posted on 2022-01-02

3784 Reliance of neuronal gene expression on cohesin scales with chromatin loop length

Calderon, L.; Weiss, F. D.; Beagan, J. A.; Oliveira, M. S.; Wang, Y.-F.; Carroll, T.; Dharmalingam, G.; Gong, W.; Tossell, K.; de Paola, V.; Whilding, C.; Ungless, M. A.; Fisher, A. G.; Phillips-Cremins, J. E.; Merkenschlager, M.

10.1101/2021.02.24.432639 — genomics — Posted on 2022-01-02

3785 Shorter effective lifespan in laboratory populations of D. melanogaster can reduce sexual selection.

Mital, A.; Sarangi, M.; Nandy, B.; Pandey, N.; Joshi, A.

10.1101/2021.04.09.439133 — evolutionary biology — Posted on 2022-01-02

3786 Meta-ecosystem dynamics drive the spatial distribution of functional groups in river networks

Jacquet, C.; Carraro, L.; Altermatt, F.

10.1101/2021.06.04.447105 — ecology — Posted on 2022-01-02

3787 Comparison of Three Individual Identification Algorithms for Sperm Whales (Physeter macrocephalus) after Automated Detection

Holmberg, J.; Gero, S.; Blount, A.; Parham, J.; Levenson, j.

10.1101/2021.12.22.473895 — ecology — Posted on 2022-01-02

3788 Prenatal murine skeletogenesis partially recovers from absent skeletal muscle as development progresses

Sotiriou, V.; Ahmed, S.; Nowlan, N.

10.1101/2022.01.01.473639 — developmental biology — Posted on 2022-01-02

3789 Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality

Koch, C. M.; Anekalla, K.; Hu, Y.-S.; Davis, J. M.; Ciesielski, M.; Gadhvi, G.; Chen, S.-Y.; Turner, M.; Cheng, Y.; Coates, B. M.; Abdala-Valencia, H.; Reyfman, P. A.; Misharin, A. V.; Budinger, G. S.; Winter, D. R.; Ridge, K. M.

10.1101/2020.06.08.141309 — immunology — Posted on 2022-01-02

3790 Schizophrenia polygenic risk during typical development reflects multiscale cortical organization

Kirschner, M.; Paquola, C.; Khundrakpam, B.; Vainik, U.; Bhutani, N.; Hodzic-Santor, B.; Georgiadis, F.; Al-Sharif, N. B.; Misic, B.; Bernhardt, B.; Evans, A. C.; Dagher, A.

10.1101/2021.06.13.448243 — neuroscience — Posted on 2022-01-02

3791 Memory Trace Imbalance in Reinforcement and Punishment Systems Can Reinforce Implicit Choices Leading to Obsessive-Compulsive Behavior

Sakai, Y.; Sakai, Y.; Abe, Y.; Narumoto, J.; Tanaka, S. C.

10.1101/2020.08.07.241588 — neuroscience — Posted on 2022-01-02

3792 Interplay between LHCSR proteins and state transitions governs the NPQ response in intact cells of Chlamydomonas during light fluctuations.

Steen, C.; Burlacot, A.; Short, A.; Niyogi, K. K.; Fleming, G.

10.1101/2021.12.31.474662 — plant biology — Posted on 2022-01-02

3793 Controlling critical mistag-associated false discoveries in metagenetic data

Richardson, R. T.

10.1101/2022.01.01.474695 — ecology — Posted on 2022-01-02

3794 Potential geographic distribution and ecological niche of the insect order Megaloptera: the case of the neartic-neotropical transition zone

Alvarez, H. A.; Rivas-Soto, M. A.

10.1101/2022.01.01.474714 — ecology — Posted on 2022-01-02

3795 Temporal control of the integrated stress response by a stochastic molecular switch

Klein, P.; Kallenberger, S. M.; Roth, H.; Roth, K.; Ly-Hartig, T. B. N.; Magg, V.; Ales, J.; Rastgou Talemi, S.; Qiang, Y.; Wolf, S.; Oleksiuk, O.; Kurilov, R.; Di Ventura, B.; Bartenschlager, R.; Eils, R.; Rohr, K.; Hamprecht, F. A.; Höfer, T.; Fackler, O. T.; Stoecklin, G.; Ruggieri, A.

10.1101/2022.01.01.474691 — cell biology — Posted on 2022-01-02

3796 Cooperative regulation of C1-domain membrane recruitment polarizes atypical Protein Kinase C

Jones, K. A.; Drummond, M. L.; Prehoda, K.

10.1101/2022.01.01.474707 — cell biology — Posted on 2022-01-02

3797 Efficient simulation of 3D reaction-diffusion in models of neurons and networks

McDougal, R. A.; Conte, C.; Eggleston, L.; Newton, A. J. H.; Galijasevic, H.

10.1101/2022.01.01.474683 — neuroscience — Posted on 2022-01-02

3798 Bacterial composition and inferring function profiles in the biofloc system rearing Litopenaeus vannamei postlarvae at a low salinity

Huang, H.-H.; Li, C.-Y.; Lei, Y.-J.; Kuang, W.-Q.; Zou, W.-S.; Yang, P.-H.

10.1101/2022.01.01.474705 — systems biology — Posted on 2022-01-02

3799 An ultra-sensitive and easy-to-use multiplexed single-cell proteomic analysis

Li, C.; Gu, L.; Li, Z. Y.; Wang, Q. Q.; Zhang, H. P.; Li, X. M.; Li, J. Q.; Sun, Y. D.; Wang, H.

10.1101/2022.01.02.474723 — systems biology — Posted on 2022-01-02

3800 PlasmidMaker: a Versatile, Automated, and High Throughput End-to-End Platform for Plasmid Construction

Enghiad, B.; Xue, P.; Singh, N.; Boob, A. G.; Shi, C.; Petrov, V. A.; Liu, R.; Peri, S. S.; Lane, S. T.; Gaither, E. D.; Zhao, H.

10.1101/2021.12.31.474679 — synthetic biology — Posted on 2022-01-02

3801 Low-cost arabinose induced genetic circuit for protein production: Modeling.

Flores Gomez, C. J.; Valeria de la Cruz, E.; Garcia Barrera, J. L.

10.1101/2021.12.31.474657 — synthetic biology — Posted on 2022-01-02

3802 Apoplastic CBM1-interacting proteins bind conserved carbohydrate binding module 1 motifs in fungal hydrolases to counter pathogen invasion

Takeda, T.; Takahashi, M.; Shimizu, M.; Sugihara, Y.; Saitoh, H.; Fujisaki, K.; Ishikawa, K.; Utsushi, H.; Kanzaki, E.; Sakamoto, Y.; Abe, A.; Terauchi, R.

10.1101/2021.12.31.474618 — plant biology — Posted on 2022-01-02

3803 Concerted expansion and contraction of immune receptor gene repertoires in plant genomes

Ngou, B. P. M.; Heal, R.; Wyler, M.; Schmid, M. W.; Jones, J. D.

10.1101/2022.01.01.474684 — plant biology — Posted on 2022-01-02

3804 Simultaneous overexpression of multiple herbicide-metabolizing genes for broad-spectrum resistance in an agricultural weed Echinochloa phyllopogon

Suda, H.; Yoshimoto, Y.; Kubo, T.; Tanaka, K.; Tanaka, S.; Yamaguchi, T.; Miyashita, M.; Tominaga, T.; Iwakami, S.

10.1101/2022.01.02.474499 — plant biology — Posted on 2022-01-02

3805 P2RX7 inhibition reduces breast cancer induced osteolytic lesions - implications for bone metastasis

Shah, K. M.; Tattersall, L.; Hussain, A.; Macfarlane, S. C.; Williamson, A.; Acosta-Martin, A. E.; Erler, J. T.; Ottewell, P. D.; Gartland, A.

10.1101/2021.12.31.474644 — cancer biology — Posted on 2022-01-02

3806 Phase tracking algorithms detect both real and imaginary components of outer hair cell nonlinear membrane capacitance that exhibits dielectric loss.

Santos-Sacchi, J.

10.1101/2022.01.01.474702 — biophysics — Posted on 2022-01-02

3807 Counting fluorescently labeled proteins in tissues in the spinning disk microscope using single-molecule calibrations

Liao, M.; Kuo, Y.-W.; Howard, J.

10.1101/2022.01.02.474734 — biophysics — Posted on 2022-01-02

3808 Structural Evolution of the Ancient Enzyme, Dissimilatory Sulfite Reductase

Colman, D. R.; Labesse, G.; Swapna, G. V. T.; Stefanakis, J.; Montelione, G. T.; Boyd, E. S.; Royer, C. A.

10.1101/2021.12.28.474277 — biophysics — Posted on 2022-01-02

3809 SpotLink enables sensitive and precise identification of site non-specific cross-links at the proteome scale

Zhang, W.; Gong, P.; Shan, Y.; Zhao, L.; Hu, H.; Wei, Q.; Liang, Z.; Liu, C.; Zhang, L.; Zhang, Y.

10.1101/2021.12.31.474672 — bioinformatics — Posted on 2022-01-02

3810 Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response

Andrechak, J. C.; Dooling, L. J.; Hayes, B. H.; Kadu, S.; Zhang, W.; Pan, R.; Vashisth, M.; Irianto, J.; Alvey, C. M.; Discher, D. E.

10.1101/2022.01.01.474150 — bioengineering — Posted on 2022-01-02

3811 High Speed Visual Insect Swarm Tracker (Hi-VISTA) used to identify the effects of confinement on individual insect flight

Ahmed, I.; Faruque, I. A.

10.1101/2021.12.31.474665 — animal behavior and cognition — Posted on 2022-01-02

3812 Whole genome sequencing of hematologically stained cells catapulted from Cell smears

Bae, S.; Jung, Y.; Kim, S.; Kim, J.; Lee, A. C.; Lee, D.; Kwon, S.

10.1101/2021.12.31.474675 — genomics — Posted on 2022-01-02

3813 Cell-based screen identifies human type I interferon-stimulated regulators of Toxoplasma gondii Infection

Gossner, A.; Raper, A.; Hassan, M. A.

10.1101/2022.01.02.474728 — genomics — Posted on 2022-01-02

3814 Investigating neurotrophin genetics and hippocampal volume

de Frutos, J.; Vacher, M.; Porter, T.; Laws, S.; Brown, B.

10.1101/2022.01.01.474700 — genetics — Posted on 2022-01-02

3815 A simple island biodiversity model is robust to trait dependence in diversification and colonization rates

Xie, S.; Valente, L.; Etienne, R.

10.1101/2022.01.01.474685 — evolutionary biology — Posted on 2022-01-02

3816 Role of vegetation characteristics on the distribution of three hornbill species in and around Pakke Tiger Reserve, Arunachal Pradesh, India

Dasgupta, S.; Bhattacharya, T.; Kaul, R.

10.1101/2022.01.01.474716 — ecology — Posted on 2022-01-02

3817 Local climate and vernalization requirements explain the latitudinal patterns of flowering initiation in the crop wild relative Linum bienne

Landoni, B.; Suarez-Montes, P.; Habeahan, R. H. F.; Brennan, A. C.; Perez-Barrales, R.

10.1101/2022.01.02.474722 — ecology — Posted on 2022-01-02

3818 Temporal variation of patch connectivity determines biodiversity recovery from recurrent disturbances

Jacquet, C.; Munoz, F.; Bonada, N.; Datry, T.; Heino, J.; Jabot, F.

10.1101/2022.01.02.474736 — ecology — Posted on 2022-01-02

3819 Applying biostimulants boosts forage productivity without affecting soil biotic and abiotic parameters on a Central Coast California rangeland

Carey, C. J.; Strohm, H.; Smith, F.; Biaggi, M.

10.1101/2021.12.31.474676 — ecology — Posted on 2022-01-02

3820 Release of HIV-1 particles from the viral compartment in macrophages requires an associated cytoskeleton and is driven by mechanical constraints

Rodrigues, V.; Taheraly, S.; Maurin, M.; San-Roman, M.; Granier, E.; Hanouna, A.; BENAROCH, P.

10.1101/2021.12.31.474638 — cell biology — Posted on 2022-01-02

3821 Dealing with the promise of metabarcoding in mega-event biomonitoring: EXPO2015 unedited data

Agostinetto, G.; Bruno, A.; Sandionigi, A.; Brusati, A.; Manzari, C.; Chiodi, A.; Siani, E.; Borruso, L.; Galimberti, A.; Pesole, G.; Labra, M.; Casiraghi, M.

10.1101/2022.01.02.474438 — molecular biology — Posted on 2022-01-02

3822 Capsaicin potently blocks Salmonella typhimurium invasion of Vero cells

Ayariga, J. A.; Abugri, D.; Amrutha, B.; Villafane, R.

10.1101/2022.01.02.474733 — microbiology — Posted on 2022-01-02

3823 Epithelial MHC class II directs microbiota-specific intestinal immune homeostasis

Eshleman, E. M.; Shao, T.-Y.; Woo, V.; Rice, T.; Whitt, J.; Engleman, L.; Way, S. S.; Alenghat, T.

10.1101/2022.01.01.473735 — immunology — Posted on 2022-01-02

3824 Region-specific alterations of perineuronal net expression in postmortem autism brain tissue

Brandenburg, C.; Blatt, G. J.

10.1101/2021.12.31.474655 — neuroscience — Posted on 2022-01-02

3825 Neuronal cell-type and circuit basis for visual predictive processing

Zou, J.; Huang, L.; Wang, L.; Xu, Y.; Li, C.; Peng, Q.; Zeng, H.; Zhang, S.; Li, L.

10.1101/2021.12.31.474667 — neuroscience — Posted on 2022-01-02

3826 An in vivo pig model for testing novel PET radioligands targeting cerebral protein aggregates

Raval, N. R.; Nasser, A.; Madsen, C. A.; Beschorner, N.; Beaman, E. E.; Juhl, M.; Lehel, S.; Palner, M.; Svarer, C.; Plaven-Sigray, P.; Jorgensen, L. M.; Knudsen, G. M.

10.1101/2021.12.31.473908 — neuroscience — Posted on 2022-01-02

3827 Inter-individual deep image reconstruction

Ho, J. K.; Horikawa, T.; Majima, K.; Kamitani, Y.

10.1101/2021.12.31.474501 — neuroscience — Posted on 2022-01-02

3828 Abnormal larval neuromuscular junction morphology and physiology in Drosophila Prickle isoform mutants with defective axonal transport and adult seizure behavior

O'Harrow, T.; Ueda, A.; Xing, X.; Ehaideb, S. N.; Manak, J. R.; Wu, C.-F.

10.1101/2021.12.31.474668 — neuroscience — Posted on 2022-01-02

3829 Synthetic Data Resource and Benchmarks for Time Cell Analysis and Detection Algorithms

Ananthamurthy, K. G.; Bhalla, U. S.

10.1101/2022.01.01.474717 — neuroscience — Posted on 2022-01-02

3830 Reduced synaptic activity and dysregulated extracellular matrix pathways are common phenotypes in midbrain neurons derived from sporadic and mutation-associated Parkinson's disease patients

Stern, S.; Lau, S.; Manole, A.; Rosh, I.; Percia, M.; Ben-Ezer, R.; Shokhirev, M.; Qiu, F.; Schafer, S.; Mansour, A.; Stern, T.; Ofer, P.; Stern, Y.; Diniz, A. M.; Moore, L. R.; Nayak, R.; Aicher, A.; Rhee, A.; Wong, T.; Nguyen, T.; Linker, S. B.; Winner, B.; Freitas, B.; Jones, E.; Bardy, C.; Brice, A.; Winkler, J.; Marchetto, M. C.; Gage, F. H.

10.1101/2021.12.31.474654 — neuroscience — Posted on 2022-01-02

3831 Efficient learning in children with rapid GABA boosting after training

Frank, S. M.; Becker, M.; Qi, A.; Geiger, P.; Frank, U. I.; Malloni, W. M.; Sasaki, Y.; Greenlee, M. W.; Watanabe, T.

10.1101/2022.01.02.474022 — neuroscience — Posted on 2022-01-02

3832 Post-Translational Tubulin Modifications in Differentiated Human Neural Stem Cells

Knight, V. B.; Jogalekar, M. P.; Serrano, E. E.

10.1101/2021.12.31.474563 — neuroscience — Posted on 2022-01-02

3833 Maturation of prefrontal input to dorsal raphe increases behavioral persistence in mice

Gutierrez-Castellanos, N.; Sarra, D.; Godinho, B.; Mainen, Z.

10.1101/2022.01.01.474690 — neuroscience — Posted on 2022-01-02

3834 Contribution of behavioural variability to representational drift

Sadeh, S.; Clopath, C.

10.1101/2022.01.02.474731 — neuroscience — Posted on 2022-01-02

3835 Multiplex labeling and manipulation of endogenous neuronal proteins using sequential CRISPR/Cas9 gene editing

Droogers, W. J.; Willems, J.; MacGillavry, H. D.; de Jong, A. P.

10.1101/2022.01.02.474730 — neuroscience — Posted on 2022-01-02

3836 Single-cell transcriptome reveals the redifferentiation trajectories of the early stage of de novo shoot regeneration in Arabidopsis thaliana

Liu, G.; Li, J.; Li, J.; Chen, Z.; Yuan, P.; Chen, R.; Yin, R.; Liao, Z.; Li, X.; Gu, Y.; Sun, H.-X.; Xia, K.

10.1101/2022.01.01.474510 — plant biology — Posted on 2022-01-02

3837 Transcriptomic changes in the pituitary of female mice with androgen excess through dihydrotestosterone (DHT) treatment

Joseph, S.; Divall, S.; Wu, S.

10.1101/2021.12.31.474680 — physiology — Posted on 2022-01-02

3838 Viscoelastic RNA entanglement and advective flow underlie nucleolar form and function

Riback, J. A.; Eeftens, J. M.; Lee, D. S. W.; Quinodoz, S. A.; Beckers, L.; Becker, L. A.; Brangwynne, C. P.

10.1101/2021.12.31.474660 — biophysics — Posted on 2022-01-02

3839 Structure determination of protein-peptide complexes from NMR chemical shift data using MELD.

Mondal, A.; Swapna, G. V. T.; Hao, J.; Ma, L.; Roth, M. J.; Montelione, G. T.; Perez, A.

10.1101/2021.12.31.474671 — biophysics — Posted on 2022-01-02

3840 GNNQQNY: Methodology for biophysical and structural understanding of aggregation

Burra, G.; Maina, M. B.; Serpell, L. C.; Thakur, A.

10.1101/2022.01.01.474692 — biophysics — Posted on 2022-01-02

3841 Development, Structure, and Mechanism of Synthetic Antibodies that Target Claudin and Clostridium perfringens Enterotoxin Complexes

Orlando, B. J.; Dominik, P. K.; Roy, S.; Ogbu, C.; Erramilli, S. K.; Kossiakoff, A. A.; Vecchio, A. J.

10.1101/2022.01.01.474715 — biophysics — Posted on 2022-01-02

3842 Correlative cryogenic montage electron tomography for comprehensive in-situ whole-cell structural studies

Yang, J. E.; Larson, M. R.; Sibert, B. S.; Kim, J. Y.; Parrell, D.; Sanchez, J. C.; Pappas, V.; Kumar, A.; Cai, K.; Thompson, K. J.; Wright, E. R.

10.1101/2021.12.31.474669 — biophysics — Posted on 2022-01-02

3843 Novel Methods for Elucidating Modality Importance in Multimodal Electrophysiology Classifiers

Ellis, C. A.; Sendi, M. S.; Zhang, R.; Carbajal, D. A.; Wang, M. D.; Miller, R. L.; Calhoun, V. D.

10.1101/2022.01.01.474276 — bioinformatics — Posted on 2022-01-02

3844 Robust hydrogel-integrated microsystems enabled by enhanced interfacial bonding strength

Bae, S.; Kim, Y.-W.; Sun, J.-Y.; Kwon, S.

10.1101/2021.12.31.474677 — bioengineering — Posted on 2022-01-02

3845 STReTCh: a strategy for facile detection of mechanical forces across proteins in cells

Zhong, B. L.; Vachharajani, V. T.; Dunn, A. R.

10.1101/2021.12.31.474658 — bioengineering — Posted on 2022-01-02

3846 Analyzing the relationship between distracted driving and eye movement using multimodal data collected during car driving

Hiroyasu, T.; Tanioka, K.; Uraki, D.; Hiwa, S.; Furutani, H.

10.1101/2021.12.31.474674 — bioengineering — Posted on 2022-01-02

3847 The TOG protein Stu2 is regulated by acetylation

Miller, R. K.; Greenlee, M. A.; Witt, B.; Sabo, J.; Morris, S. C.

10.1101/2021.12.31.474666 — genetics — Posted on 2022-01-02

3848 Pachytene karyotypes of 17 species of birds

Slobodchikova, A.; Malinovskaya, L.; Grishko, E.; Pristyazhnyuk, I.; Torgasheva, A.; Borodin, P.

10.1101/2022.01.01.473627 — genetics — Posted on 2022-01-02

3849 The hidden structural variability in avian genomes

Peona, V.; Blom, M.; Frankl-Vilches, C.; Mila, B.; Ashari, H.; Thebaud, C.; Benz, B. W.; Christidis, L.; Gahr, M.; Irestedt, M.; Suh, A.

10.1101/2021.12.31.473444 — evolutionary biology — Posted on 2022-01-02

3850 Meta-analysis of the genetic loci of pigment pattern evolution in vertebrates

Elkin, J.; Martin, A.; Courtier-Orgogozo, V.; Santos, M. E.

10.1101/2022.01.01.474697 — evolutionary biology — Posted on 2022-01-02

3851 Northward Expansion of Amblyomma americanum (Acari: Ixodidae) into Southern Michigan

Fowler, P. D.; Nguyentran, S.; Quantroche, L. M.; Porter, M.; Kobbekaduwa, V.; Tippin, S.; Miller, G.; Dinh, E.; Foster, E.; Tsao, J.

10.1101/2021.12.31.474651 — ecology — Posted on 2022-01-02

3852 Importance Of Small Diameter Woody Plants And Treelet Species In Tropical Wet Evergreen Forest Of Southern Western Ghats, India

Sreejith, K. A.; Sanil, M. S.; Prasad, T. S.; Prejith, M. P.; Sreekumar, V. B.; Murali, A.

10.1101/2021.12.31.474647 — ecology — Posted on 2022-01-02

3853 Cyanopeptides Restriction and Degradation Co-mediate Microbiota Assembly During a Freshwater Cyanobacterial Harmful Algal Bloom (CyanoHAB)

Gao, H.; Zhao, Z.; Zhang, L.; Ju, F.

10.1101/2021.12.31.474673 — ecology — Posted on 2022-01-02

3854 oca2 targeting using CRISPR/Cas9 in the Malawi cichlid Astatotilapia calliptera

Clark, B.; Elkin, J.; Marconi, A.; Turner, G. F.; Smith, A. M.; Joyce, D.; Miska, E. A.; Juntti, S. A.; Santos, M. E.

10.1101/2022.01.01.474687 — developmental biology — Posted on 2022-01-02

3855 Isoforms of the transcriptional cofactor SIN3 differentially regulate genes necessary for energy metabolism and cell survival

Mitra, A.; Vo, L.; Soukar, I.; Chaubal, A.; Greenberg, M.; Pile, L.

10.1101/2021.12.31.474661 — molecular biology — Posted on 2022-01-02

3856 Production and cross-feeding of nitrite within Prochlorococcus populations

Berube, P. M.; O'Keefe, T. J.; Rasmussen, A. N.; Chisholm, S. W.

10.1101/2021.12.31.474641 — microbiology — Posted on 2022-01-02

3857 Adjunctive inhibition of the integrated stress response pathway accelerates bacterial clearance in a mouse model of tuberculosis

Krug, S.; Prasad, P.; Xiao, S.; Lun, S.; Ruiz-Bedoya, C. A.; Klunk, M.; Ordonez, A. A.; Jain, S. K.; Srikrishna, G.; Kramnik, I.; Bishai, W.

10.1101/2021.12.31.474642 — microbiology — Posted on 2022-01-02

3858 Testing the state-dependent model of time perception against experimental evidence

Ravichandran-Schmidt, P.; Hass, J.

10.1101/2021.12.31.474629 — neuroscience — Posted on 2022-01-02

3859 Expectation violations produce error signals in mouse V1

Price, B. H.; Jensen, C. M.; Khoudary, A. A.; Gavornik, J. P.

10.1101/2021.12.31.474652 — neuroscience — Posted on 2022-01-02

3860 AVATAR: AI Vision Analysis for Three-dimensional Action in Real-time

Kim, D.; Kim, D.-G.; Shin, A.; Jeong, Y.-C.; Park, S.

10.1101/2021.12.31.474634 — neuroscience — Posted on 2022-01-02

3861 Interplay between LHCSR proteins and state transitions governs the NPQ response in intact cells of Chlamydomonas during light fluctuations.

Steen, C.; Burlacot, A.; Short, A.; Niyogi, K. K.; Fleming, G.

10.1101/2021.12.31.474662 — plant biology — Posted on 2022-01-02

3862 Liquid condensate is a common state of proteins and polypeptides at the regime of high intermolecular interactions

Poudyal, M.; Patel, K.; Sawner, A. S.; Gadhe, L.; Kadu, P.; Datta, D.; Mukherjee, S.; Ray, S.; Navalkar, A.; Maiti, S.; Chatterjee, D.; Bera, R.; Gahlot, N.; Padinhateeri, R. K.; Maji, S. K.

10.1101/2021.12.31.474648 — biophysics — Posted on 2022-01-02

3863 Dynamic characteristics and Functional Analysis Provide new insights into the role of GauERF105 in resistance against Verticillium wilt in Cotton

UMER, M. J.; Wang, Y.; HOU, Y.; XU, Y.; MEHARI, T. G.; ZHENG, J.; WANG, Y.; ZHOU, Z.; LI, Z.; LIU, F.

10.1101/2021.12.30.474616 — pathology — Posted on 2022-01-02

3864 NeoRdRp: A comprehensive dataset for identifying RNA-dependent RNA polymerase of various RNA viruses from metatranscriptomic data

Sakaguchi, S.; Urayama, S.-i.; Takaki, Y.; Wu, H.; Suzuki, Y.; Nunoura, T.; Nakano, T.; Nakagawa, S.

10.1101/2021.12.31.474423 — microbiology — Posted on 2022-01-02

3865 Prelimbic proBDNF facilitates memory destabilization by regulation of neuronal function in juveniles

Sun, W.; Chen, X.; Mei, Y.; Yang, Y.; Li, X.; An, L.

10.1101/2021.12.30.474526 — neuroscience — Posted on 2022-01-02

3866 A remote lecture series roadmap to equity, diversity, and inclusion in STEM

10.1101/2021.12.05.471284 — scientific communication and education — Posted on 2022-01-02

3867 Protein Complex Structure Prediction Powered by Multiple Sequence Alignments of Interologs from Multiple Taxonomic Ranks and AlphaFold2

Si, Y.; Yan, C.

10.1101/2021.12.21.473437 — bioinformatics — Posted on 2022-01-02

3868 Comprehensive evaluation of machine learning models and gene expression signatures for prostate cancer prognosis using large population cohorts

Li, R.; Zhu, J.; Zhong, W.-D.; Jia, Z.

10.1101/2021.07.02.450975 — bioinformatics — Posted on 2022-01-02

3869 In Vivo Transcriptomic Profiling using Cell Encapsulation Identifies Effector Pathways of Systemic Aging

Mashinchian, O.; Hong, X.; Michaud, J.; Migliavacca, E.; Lefebvre, G.; Boss, C.; De Franceschi, F.; Le Moal, E.; Collerette-Tremblay, J.; Isern, J.; Metairon, S.; Raymond, F.; Descombes, P.; Bouche, N.; Munoz-Canoves, P.; Feige, J. N.; Bentzinger, C. F.

10.1101/2020.03.09.979054 — bioengineering — Posted on 2022-01-02

3870 An analytical solution simulating growth of Lewy bodies

Kuznetsov, I. A.; Kuznetsov, A. V.

10.1101/2021.12.22.473938 — bioengineering — Posted on 2022-01-02

3871 High-plex Multiomic Analysis in FFPE at Subcellular Level by Spatial Molecular Imaging

He, S.; Bhatt, R.; Brown, C.; Brown, E. A.; Buhr, D. L.; Chantranuvatana, K.; Danaher, P.; Dunaway, D.; Garrison, R. G.; Geiss, G.; Gregory, M. T.; Hoang, M. L.; Khafizov, R.; Killingbeck, E. E.; Kim, D.; Kim, T. K.; Kim, Y.; Klock, A.; Korukonda, M.; Kutchma, A.; Lee, E.; Lewis, Z. R.; Liang, Y.; Nelson, J. S.; Ong, G. T.; Perillo, E. P.; Phan, J. C.; Phan-Everson, T.; Piazza, E.; Rane, T.; Reitz, Z.; Rhodes, M.; Rosenbloom, A.; Ross, D.; Sato, H.; Wardhani, A. W.; Williams-Wietzikoski, C. A.; Wu, L.; Beechem, J. M.

10.1101/2021.11.03.467020 — genomics — Posted on 2022-01-02

3872 Coevolution of relative brain size and life expectancy in parrots

Smeele, S. Q.; Conde, D. A.; Baudisch, A.; Bruslund, S.; Iwaniuk, A.; Staerk, J.; Wright, T. F.; Young, A. M.; McElreath, M. B.; Aplin, L.

10.1101/2021.10.28.466243 — evolutionary biology — Posted on 2022-01-02

3873 Genomic structure predicts metabolite dynamics in microbial communities

Gowda, K.; Ping, D.; Mani, M.; Kuehn, S.

10.1101/2020.09.29.315713 — ecology — Posted on 2022-01-02

3874 Memory Trace Imbalance in Reinforcement and Punishment Systems Can Reinforce Implicit Choices Leading to Obsessive-Compulsive Behavior

Sakai, Y.; Sakai, Y.; Abe, Y.; Narumoto, J.; Tanaka, S. C.

10.1101/2020.08.07.241588 — neuroscience — Posted on 2022-01-02

3875 Evidence or Confidence: What Really Accumulates During a Decision?

Lee, D. G.; Daunizeau, J.; Pezzulo, G.

10.1101/2021.04.02.438275 — neuroscience — Posted on 2022-01-02

3876 Analysis and extension of exact mean-field theory with dynamic synaptic currents

Ruffini, G.

10.1101/2021.09.01.458563 — neuroscience — Posted on 2022-01-02

3877 The non-specific Lipid Transfer Protein (nsLTP) is involved at early and late stages of symbiosis between Alnus glutinosa and Frankia alni.

Gasser, M.; Alloisio, N.; Fournier, P.; Balmand, S.; Kharrat, O.; Tulumello, J.; Heddi, A.; Da Silva, P.; Normand, P.; Boubakri, H.; Pujic, P.

10.1101/2021.10.29.465983 — plant biology — Posted on 2022-01-02

3878 Rheology of crossbridge ensembles

Nguyen, K. D.; Venkadesan, M.

10.1101/2021.12.29.474482 — biophysics — Posted on 2022-01-02

3879 MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect

Tareen, A.; Kooshkbaghi, M.; Posfai, A.; Ireland, W. T.; McCandlish, D. M.; Kinney, J. B.

10.1101/2020.07.14.201475 — bioinformatics — Posted on 2022-01-02

3880 PCaDB - a comprehensive and interactive database for transcriptomes from prostate cancer population cohorts

Li, R.; Zhu, J.; Zhong, W.-D.; Jia, Z.

10.1101/2021.06.29.449134 — bioinformatics — Posted on 2022-01-02

3881 Mutualism-enhancing mutations dominate early adaptation in a microbial community

Venkataram, S.; Kuo, H.-Y.; Hom, E. F. Y.; Kryazhimskiy, S.

10.1101/2021.07.07.451547 — evolutionary biology — Posted on 2022-01-02

3882 Fast parametric curve matching (FPCM) for automatic spike detection

Kleeva, D.; Soghoyan, G.; Komoltsev, I.; Sinkin, M.; Ossadtchi, A.

10.1101/2021.12.31.474621 — neuroscience — Posted on 2022-01-01

3883 Theta- and gamma-band oscillatory uncoupling in the macaque hippocampus

Abbaspoor, S.; Hussin, A.; Hoffman, K. L.

10.1101/2021.12.30.474585 — neuroscience — Posted on 2022-01-01

3884 The 24-chain core-shell nanostructure of wood cellulose microfibrils in seed plants

Chang, C.-H.; Cai, W.; Lin, J.-H.; Huang, S.-J.; Lin, Y.-C. J.; Tsao, C.-S.; Tai, H.-C.

10.1101/2021.12.31.474620 — plant biology — Posted on 2022-01-01

3885 Structure-function relationships in mitochondrial transcriptional condensates

Feric, M.; Sarfallah, A.; Dar, F.; Temiakov, D.; Pappu, R. V.; Misteli, T.

10.1101/2021.12.30.474545 — biophysics — Posted on 2022-01-01

3886 Genomic analyses identify biological processes in ZKSCAN3-deficient colorectal cancer cells

Qian, Z.; Chang, T.; Zhang, T.; Wang, J.; Gu, H.

10.1101/2021.12.30.474589 — bioinformatics — Posted on 2022-01-01

3887 Escherichia coli chemotaxis to competing stimuli in a microfluidic device with a constant gradient

Zhao, X.; Ford, R. M.

10.1101/2021.12.30.474376 — bioengineering — Posted on 2022-01-01

3888 Acoustic and vibrational signaling in true katydid Nesoecia nigrispina: three means of sound production in the one species

Korsunovskaya, O. S.; Zhantiev, R. D.

10.1101/2021.12.30.474575 — animal behavior and cognition — Posted on 2022-01-01

3889 Functional Requirements for a Samd14-Capping Protein Complex in Stress Erythropoiesis

Ray, S.; Chee, L.; Zhou, Y.; Schaefer, M. A.; Naldrett, M. J.; Alvarez, S.; Woods, N. T.; Hewitt, K.

10.1101/2021.12.31.474625 — cell biology — Posted on 2022-01-01

3890 ZC3HC1 is a structural element of the nuclear basket effecting interlinkage of TPR polypeptides

Gunkel, P.; Cordes, V. C.

10.1101/2021.12.30.474576 — cell biology — Posted on 2022-01-01

3891 Triple-helix potential of the mouse genome

Maekawa, K.; Yamada, S.; Sharma, R.; Chauduri, J.; Keeney, S.

10.1101/2021.12.31.474609 — molecular biology — Posted on 2022-01-01

3892 NeoRdRp: A comprehensive dataset for identifying RNA-dependent RNA polymerase of various RNA viruses from metatranscriptomic data

Sakaguchi, S.; Urayama, S.-i.; Takaki, Y.; Wu, H.; Suzuki, Y.; Nunoura, T.; Nakano, T.; Nakagawa, S.

10.1101/2021.12.31.474423 — microbiology — Posted on 2022-01-01

3893 The Rhizosphere Bacterial Communities Differ Among Domesticated Maize Landraces - An Experimental Confirmation

Lund, M.; Rasmussen, J. A.; Ramos-Madrigal, J.; Gilbert, M. T. P.; Barnes, C. J.

10.1101/2021.12.30.474574 — microbiology — Posted on 2022-01-01

3894 White-matter degradation and dynamical compensation support age-related functional alterations in human brain

Petkoski, S.; Ritter, P.; Jirsa, V.

10.1101/2021.12.30.474565 — neuroscience — Posted on 2022-01-01

3895 Patterns of Arc mRNA expression in the rat brain following dual recall of fear- and reward-based socially acquired information

Agee, L. A.; Hilz, E. N.; Jun, D.; Lee, H. J.; Monfils, M. H.

10.1101/2021.12.30.474464 — neuroscience — Posted on 2022-01-01

3896 NETISCE: A Network-Based Tool for Cell Fate Reprogramming

Marazzi, L.; Shah, M.; Balakrishnan, S.; Patil, A.; Vera-Licona, P.

10.1101/2021.12.30.474582 — systems biology — Posted on 2022-01-01

3897 Thylakoid grana stacking revealed by multiplex genome editing of LHCII encoding genes

Guardini, Z.; Gomez, R. L.; Caferri, R.; Stuttmann, J.; Dall'Osto, L.; Bassi, R.

10.1101/2021.12.31.474624 — plant biology — Posted on 2022-01-01

3898 Normal Reproductive function in male mice lacking pituitary kisspeptin receptor.

Ma, Y.; Awe, O.; Radovick, S.; Yang, X.; Divall, S.; Wolfe, A.; Wu, S.

10.1101/2021.12.30.474587 — physiology — Posted on 2022-01-01

3899 Exercise and the brain: a mechanical model for pulsation on flow of cerebrospinal fluid

Hale, M. G.; Coles, J. A.

10.1101/2021.12.30.474515 — physiology — Posted on 2022-01-01

3900 Novel enhancers of guanylyl cyclase-A activity via allosteric modulation

Andresen, H.; Perez-Ternero, C.; Robinson, J.; Dickey, D. M.; Hobbs, A. J.; Potter, L. R.; Levy, F. O.; Cataliotti, A.; Moltzau, L. R.

10.1101/2021.12.31.474340 — pharmacology and toxicology — Posted on 2022-01-01

3901 VRK1 is a Paralog Synthetic Lethal Target in VRK2-methylated Glioblastoma

Shields, J. A.; Meier, S. R.; Bandi, M.; Dam Ferdinez, M.; Engel, J. L.; Mulkearns-Hubert, E. E.; Hajdari, N.; Mitchell, K.; Zhang, W.; Zhao, S.-c.; Zhang, M.; Tjin Tham Sjin, R.; Wilker, E.; Lathia, J.; Andersen, J.; Chen, Y.; Li, F.; Weber, B.; Huang, A.; Emmanuel, N.

10.1101/2021.12.30.474571 — cancer biology — Posted on 2022-01-01

3902 Cell adhesion strength and tractions are mechano-diagnostic features of cellular invasiveness

Paddillaya, N.; Ingale, K.; Gaikwad, C.; Saini, D. K.; Pullarkat, P. A.; Kondaiah, P.; Menon, G. I.; Gundiah, N.

10.1101/2021.12.30.474608 — bioengineering — Posted on 2022-01-01

3903 P-TEFb is degraded by Siah1/2 in quiescent cells

Huang, F.; Feng, Y.; Peterlin, B. M.; Fujinaga, K.

10.1101/2021.12.30.474394 — biochemistry — Posted on 2022-01-01

3904 Vocal traits of shorebird chicks are related to body mass and sex

Kostoglou, K. N.; Miller, E. H.; Weston, M. A.; Wilson, D. R.

10.1101/2021.12.30.474581 — animal behavior and cognition — Posted on 2022-01-01

3905 Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7

Lang, T.; Pelaseyed, T.

10.1101/2021.12.31.474548 — genetics — Posted on 2022-01-01

3906 Cell type-specific interpretation of noncoding variants using deep learning-based methods

Sindeeva, M.; Chekanov, N.; Avetisian, M.; Baranov, N.; Malkin, E.; Lapin, A.; Kardymon, O.; Fishman, V.

10.1101/2021.12.31.474623 — genetics — Posted on 2022-01-01

3907 Parasite defensive limb movements enhance signal attraction in male little torrent frogs: insight into the evolution of multimodal signals

Zhao, L.; Wang, J.; Zhang, H.; Wang, T.; Yang, Y.; Tang, Y.; Halfwerk, W.; Cui, J.

10.1101/2021.12.31.474622 — evolutionary biology — Posted on 2022-01-01

3908 Phenolic degradation by catechol dioxygenases is associated with pathogenic fungi with a necrotrophic lifestyle in the Ceratocystidaceae

Soal, N.; Coetzee, M. H.; van der Nest, M. A.; Hammerbacher, A.; Wingfield, B.

10.1101/2021.12.30.474597 — evolutionary biology — Posted on 2022-01-01

3909 Seasonal challenges of tropical bats (Rousettus aegyptiacus) in temperate zones

Weinberg, M.; Mazar, O.; Goutnik, S.; Harten, L.; Handel, M.; Czirjak, G. A.; Yovel, Y.

10.1101/2021.12.31.473712 — ecology — Posted on 2022-01-01

3910 High affinity enhancer-promoter interactions can bypass CTCF/cohesin-mediated insulation and contribute to phenotypic robustness

Chakraborty, S.; Kopitchinski, N.; Eraso, A.; Awasthi, P.; Chari, R.; Rocha, P. P.

10.1101/2021.12.30.474562 — developmental biology — Posted on 2022-01-01

3911 Plasma membrane phosphatidylinositol-4-phosphate is not necessary for Candida albicans viability, yet is key for cell wall integrity and systemic infection

Garcia-Rodas, R.; Labbaoui, H.; Orange, F.; Solis, N.; Zaragoza, O.; Filler, S.; Bassilana, M.; Arkowitz, R. A.

10.1101/2021.12.31.474627 — cell biology — Posted on 2022-01-01

3912 Rsc3K, a SMV resistance gene localized on chromosome 2 in soybean cv. Kefeng No.1, interacts with virulence determinant P3

Jin, T.; Yin, J.; Xue, S.; Li, B.; Zong, T.; Yang, Y.; Liu, H.; Liu, M.; Xu, K.; Li, K.; Wang, L.; Zhi, H.

10.1101/2021.12.30.474612 — molecular biology — Posted on 2022-01-01

3913 New 63 knot and other knots in human proteome from AlphaFold predictions

Perlinska, A. P.; Niemyska, W. H.; Gren, B. A.; Rubach, P.; Sulkowska, J. I.

10.1101/2021.12.30.474018 — molecular biology — Posted on 2022-01-01

3914 An in vitro and computational validation of a novel loss-of-functional mutation in PAX9 associated with non-syndromic tooth agenesis

Sarkara, T.; Ranjan, P.; Kanathur, S.; Gupta, A.; DAS, P.

10.1101/2021.12.31.471205 — molecular biology — Posted on 2022-01-01

3915 Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

Cohen, A.; Jeng, E.; Voorhies, M.; Symington, J.; Ali, N.; Bassik, M.; Sil, A.

10.1101/2021.12.30.474615 — microbiology — Posted on 2022-01-01

3916 Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

Mikelov, A. I.; Alekseeva, E. I.; Komech, E. A.; Staroverov, D. B.; Turchaninova, M. A.; Shugay, M.; Chudakov, D. M.; Bazykin, G. A.; Zvyagin, I. V.

10.1101/2021.12.30.474135 — immunology — Posted on 2022-01-01

3917 Oxytocin modulates social brain network correlations in resting and task state

Wu, Q.; Huang, Q.; Liu, C.; Wu, H.

10.1101/2021.12.30.474596 — neuroscience — Posted on 2022-01-01

3918 A systematic characterization of intrinsically formed microglia-like cells during retinal organoid differentiation.

Bartalska, K.; Hübschmann, V.; Korkut-Demirbas, M.; Cubero, R. J. A.; Venturino, A.; Rössler, K.; Czech, T.; Siegert, S.

10.1101/2021.12.30.474511 — neuroscience — Posted on 2022-01-01

3919 V1 receptive field structure contributes to neuronal response latency

Vafaei, A.; Mohammadi, M.; Khadir, A.; Zabeh, E.; YazdaniBanafsheDaragh, F.; Khorasani, M.; Lashgari, R.

10.1101/2021.12.30.474591 — neuroscience — Posted on 2022-01-01

3920 Impaired endogenous neurosteroid signaling contributes to behavioral deficits associated with chronic stress

Walton, N. L.; Antonoudiou, P.; Barros, L.; DiLeo, A.; Gabby, J.; Howard, S.; Paracha, R.; Sanchez, E. J.; Weiss, G. L.; Kong, D.; Maguire, J.

10.1101/2021.12.30.474579 — neuroscience — Posted on 2022-01-01

3921 The synaptic organization in the C. elegans neural network suggests significant local compartmentalized computations

Ruach, R.; Ratner, N.; Emmons, S. W.; Zaslaver, A.

10.1101/2021.12.30.474568 — neuroscience — Posted on 2022-01-01

3922 Muscarinic acetylcholine receptors modulate HCN channel properties in vestibular ganglion neurons

Bronson, D.; Kalluri, R.

10.1101/2021.12.30.474193 — neuroscience — Posted on 2022-01-01

3923 INFLUENCE OF RAT CENTRAL THALAMIC NEURONS ON FORAGING BEHAVIOR IN A HAZARDOUS ENVIRONMENT

Herzallah, M.; Amir, A.; Pare, D.

10.1101/2021.12.31.474632 — neuroscience — Posted on 2022-01-01

3924 Microglia influence neurofilament deposition in ALS iPSC-derived motor neurons

Allison, R. L.; Adelman, J. W.; Abrudan, J.; Urrutia, R. A.; Zimmermann, M. T.; Mathison, A.; Ebert, A.

10.1101/2021.12.30.474573 — neuroscience — Posted on 2022-01-01

3925 A common human brain-derived neurotrophic factor polymorphism leads to sustained depression of excitatory synaptic transmission by isoflurane in hippocampus

Williams, R. A.; Johnson, K. W.; Lee, F. S.; Hemmings, H. C.; Platholi, J.

10.1101/2021.12.30.474566 — neuroscience — Posted on 2022-01-01

3926 Superficial white matter microstructure affects processing speed in cerebral small vessel disease

Wang, S.; Zhang, F.; Huang, P.; Hong, H.; Jiaerken, Y.; Yu, X.; zhang, R.; Zeng, Q.; Zhang, Y.; Kikinis, R.; Rathi, Y.; Makris, N.; Lou, M.; Pasternak, O.; Zhang, M.; O'Donnell, L. J.

10.1101/2021.12.30.474604 — neuroscience — Posted on 2022-01-01

3927 Global ecomorphological restructuring of dominant marine reptiles prior to the K/Pg mass extinction

MacLaren, J. A.; Bennion, R. F.; Bardet, N.; Fischer, V.

10.1101/2021.12.30.474572 — paleontology — Posted on 2022-01-01

3928 Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancer

Tonelli, C.; Deschenes, A.; Yao, M. A.; Park, Y.; Tuveson, D. A.

10.1101/2021.12.31.472823 — cancer biology — Posted on 2022-01-01

3929 Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices

Akyuz, N.; Karavitaki, K. D.; Pan, B.; Tamvakologos, P. I.; Brock, K. P.; Li, Y.; Marks, D. S.; Corey, D. P.

10.1101/2021.12.30.474567 — biophysics — Posted on 2022-01-01

3930 DNA origami as a nanomedicine for targeted rheumatoid arthritis therapy through reactive oxygen species and nitric oxide scavenging

Ma, Y.; Lu, Z.; Shi, Y.; Li, Z.

10.1101/2021.12.30.474611 — bioengineering — Posted on 2022-01-01

3931 Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

Helsley, R. N.; Miyata, T.; Kadam, A.; Venkateshwari, V.; Sangwan, N.; Huang, E. C.; Banerjee, R.; Brown, A. L.; Fung, K. K.; Massey, W.; Neumann, C.; Danny, O.; Osborn, L. J.; Schugar, R. C.; McMullen, M. R.; Bellar, A.; Poulsen, K. L.; Kim, A.; Pathak, V.; Mrdjen, M.; Anderson, J. T.; Willard, B.; McClain, C. J.; Mitchell, M.; McCullough, A. J.; Radaeva, S.; Barton, B.; Szabo, G.; Dasarathy, S.; Garcia-Garcia, J. C.; Rotroff, D. M.; Allende, D. S.; Wang, Z.; Hazen, S. L.; Nagy, L. E.; Brown, J. M.

10.1101/2021.12.31.474633 — biochemistry — Posted on 2022-01-01

3932 The gut microbiota affects the social network of honeybees

Liberti, J.; Kay, T.; Quinn, A.; Kesner, L.; Frank, E. T.; Cabirol, A.; Richardson, T. O.; Engel, P.; Keller, L.

10.1101/2021.12.31.474534 — animal behavior and cognition — Posted on 2022-01-01

3933 In silico Elucidation of Dihydroquinine Mechanism of Action against Toxoplasma gondii

Ayariga, J. A.; Huffman, A. M.; Napier, A.; Robertson, B.; Abugri, D.

10.1101/2021.12.30.474617 — cell biology — Posted on 2022-01-01

3934 Roles for Mitochondrial Complex I subunits in regulating synaptic transmission and growth

Mallik, B.; Frank, C. A.

10.1101/2021.12.30.474605 — neuroscience — Posted on 2022-01-01

3935 A Xenopus neuromast bioassay for chemical ototoxicity

Knight, V. B.; Luna, A. R.; Serrano, E.

10.1101/2021.12.30.474606 — neuroscience — Posted on 2022-01-01

Archive, 2022-01