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Archive, 2021-01

5 Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes
Fasolino, M.; Schwartz, G. W.; Golson, M.; Wang, Y. J.; Morgan, A.; Liu, C.; Schug, J.; Liu, J.; Wu, M.; Traum, D.; Kondo, A.; May, C.; Goldman, N.; Wang, W.; HPAP Consortium, ; Feldman, M.; Moore, J.; Japp, A.; Betts, M.; Faryabi, R. B.; Naji, A.; Kaestner, K.; Vahedi, G.
10.1101/2021.01.28.428598 — genomics — Posted on 2021-01-31
9 Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions
Findley, A. S.; Monziani, A.; Richards, A. L.; Rhodes, K.; Ward, M. C.; Kalita, C. A.; Alazizi, A.; Pazokitoroudi, A.; Sankararaman, S.; Wen, X.; Lanfear, D. E.; Pique-Regi, R.; Gilad, Y.; Luca, F.
10.1101/2021.01.29.428868 — genomics — Posted on 2021-01-31
10 Evolutionary genetic integration of behavioural and endocrine components of the stress response
Houslay, T. M.; Earley, R. L.; White, S. J.; Lammers, W.; Grimmer, A. J.; Travers, L.; Johnson, E.; Young, A. J.; Wilson, A. J.
10.1101/770586 — evolutionary biology — Posted on 2021-01-31
11 SiCEP3, a C-terminally encoded peptides from Setaria italica, promotes ABA import and signaling pathway
Zhang, L.; Ren, Y.; Wan, Y.; Xu, Q.; Zhang, S.; Yang, G.; Huang, J.; yan, k.; Zheng, C.-C.; Wu, C.
10.1101/2021.01.30.428944 — cell biology — Posted on 2021-01-31
12 Natural IgA and TNFRSF13B polymorphism: a double edged sword fueling balancing selection
Platt, J. L.; de Mattos Barbosa, M. G.; Huynh, D.; Leferts, A. R.; Katta, J.; Kharas, C.; Freddolino, P.; Bassis, C. M.; Wobus, C. E.; Geha, R.; Bram, R. J.; Nunez, G.; Kamada, N.; Cascalho, M.
10.1101/2021.01.29.428850 — immunology — Posted on 2021-01-31
14 Restoration of motor-evoked cortical activity is a distinguishing feature of the most effective rehabilitation therapy after stroke
Conti, E.; ALLEGRA mascaro, A. L.; Scaglione, A.; de Vito, G.; Calugi, F.; Pasquini, M.; Pizzorusso, T.; Micera, S.; Pavone, F. S.
10.1101/2020.03.05.974972 — neuroscience — Posted on 2021-01-31
16 Quantitative prediction of conditional vulnerabilities in regulatory and metabolic networks of Mycobacterium tuberculosis
Immanuel, S. R. C.; Arrieta-Ortiz, M. L.; Ruiz, R. A.; Pan, M.; de Lomana, A. L. G.; Peterson, E. J. R.; Baliga, N. S.
10.1101/2021.01.29.428876 — systems biology — Posted on 2021-01-31
17 Metabolic flux partitioning between the TCA cycle and glyoxylate shunt combined with a reversible methyl citrate cycle provide nutritional flexibility for Mycobacterium tuberculosis
Borah, K.; Mendum, T. A.; Hawkins, N.; Ward, J.; Beale, M.; Larrouy-Maumus, G.; Bhatt, A.; Pichler, H.; MOULIN, M.; Haertlein, M.; Forsyth, T.; Noack, S.; Goulding, C.; McFadden, J.; Beste, D. J.
10.1101/2021.01.29.428863 — systems biology — Posted on 2021-01-31
18 An artificial self-assembling nanocompartment for organising metabolic pathways in yeast
Cheah, L. C.; Stark, T.; Adamson, L.; Abidin, R. S.; Lau, Y. H.; Sainsbury, F.; Vickers, C. E.
10.1101/2021.01.30.428974 — synthetic biology — Posted on 2021-01-31
21 Proton egress pathway during the S1 to S2 transition of the Oxygen Evolving Complex ofPhotosystem II
Kaur, D.; Zhang, Y.; Reiss, K. M.; Mandal, M.; Brudvig, G. W.; Batista, V. S.; Gunner, M. R.
10.1101/2021.01.29.428861 — biophysics — Posted on 2021-01-31
24 DRscDB: A single-cell RNA-seq resource for data mining and data comparison across species
Hu, Y.; Tattikota, S. G.; Liu, Y.; Comjean, A.; Gao, Y.; Forman, C.; Kim, G.; Rodiger, J.; Papatheodorou, I.; Santos, G. D.; Mohr, S.; Perrimon, N.
10.1101/2021.01.29.428862 — bioinformatics — Posted on 2021-01-31
26 Whole-genome analysis of de novo and polymorphic retrotransposon insertions in Autism Spectrum Disorder
Borges Monroy, R.; Chu, C.; Dias, C.; Choi, J.; Lee, S.; Gao, Y.; Shin, T.; Park, P. J.; Walsh, C. A.; Lee, E. A.
10.1101/2021.01.29.428895 — genetics — Posted on 2021-01-31
30 A Mycobacterium tuberculosis effector targets mitochondrion, controls energy metabolism and limits cytochrome c exit.
Martin, M.; deVisch, A.; Barthe, P.; Turapov, O.; Aydogan, T.; Heriaud, L.; Gracy, J.; Mukamolova, G.; Letourneur, F.; Cohen-Gonsaud, M.
10.1101/2021.01.31.428746 — microbiology — Posted on 2021-01-31
31 Single-cell sequencing reveals clonally expanded plasma cells during chronic viral infection produce virus-specific and cross-reactive antibodies
Neumeier, D.; Pedrioli, A.; Genovese, A.; Sandu, I.; Ehling, R.; Hong, K.-L.; Papadopoulou, C.; Agrafiotis, A.; Kuhn, R.; Robbiani, D.; Han, J.; Hauri, L.; Csepregi, L.; Greiff, V.; Merkler, D.; Reddy, S. T.; Oxenius, A.; Yermanos, A.
10.1101/2021.01.29.428852 — immunology — Posted on 2021-01-31
32 Quantitative analysis and genome-scale modeling of human CD4+ T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathways
Sen, P.; Andrabi, S. B. A.; Buchacher, T.; Khan, M. M.; Ullah, U.; Lindeman, T.; Alves Amaral, M.; Hinkkanen, V.; Kemppainen, E.; Dickens, A. M.; Rasool, O.; Hyotylainen, T.; Lahesmaa, R.; Oresic, M.
10.1101/2021.01.29.428853 — immunology — Posted on 2021-01-31
33 Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates
Sakai, S.; Lora, N. E.; Kauffman, K. D.; Dorosky, D. E.; Oh, S.; Namasivayam, S.; Gomez, F.; Fleegle, J. D.; Lindestam Arlehamn, C. S.; Sher, A.; Freeman, G. J.; Via, L. E.; Barry, C. E.; Barber, D. L.
10.1101/2021.01.29.428844 — immunology — Posted on 2021-01-31
34 Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice
Boast, B.; Helian, K.; Andrews, D.; Li, X.; Cho, V.; Closa Mosquera, A.; Sutton, H. J.; Reed, J. H.; Bergmann, H.; Roots, C. M.; Yabas, M.; Barthel, N.; Omari, S. A.; Young, C.; Miosge, L. A.; Eyras, E.; Nutt, S. L.; Hein, N.; Hannan, K. M.; Cockburn, I. A.; Goodnow, C. C.; Enders, A.
10.1101/2021.01.29.428877 — immunology — Posted on 2021-01-31
35 Antisense therapy in a new rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.
Hagemann, T. L.; Powers, B.; Lin, N.-H.; Mohamed, A. F.; Dague, K. L.; Hannah, S. C.; Mazur, C.; Rigo, F.; Feany, M. B.; Perng, M.-D.; Berman, R. F.; Messing, A.
10.1101/2021.01.29.428244 — neuroscience — Posted on 2021-01-31
36 Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets
Mimura, K.; Nagai, Y.; Inoue, K.-i.; Matsumoto, J.; Hori, Y.; Sato, C.; Takada, M.; Suhara, T.; Higuchi, M.; Minamimoto, T.
10.1101/2021.01.29.428749 — neuroscience — Posted on 2021-01-31
41 Atg8 licenses adipokine nuclear exit
Poling, M. E.; Sullivan, C. E.; Brent, A. E.; Hafer, T. L.; Rajan, A.
10.1101/2021.01.29.428913 — physiology — Posted on 2021-01-31
43 Nephrotoxicity of the BRAF-kinase inhibitor Vemurafenib isdriven by off-target Ferrochelatase inhibition
Bai, Y.; Kim, J. Y.; Jayne, L. A.; Gandhi, M.; Huang, K. M.; Silvaroli, J. A.; Sander, V.; Prosek, J.; Jhaveri, K. D.; Baker, S. D.; Sparreboom, A.; Bajwa, A.; Pabla, N. S.
10.1101/2021.01.29.428783 — pharmacology and toxicology — Posted on 2021-01-31
47 Cardiac progenitors auto-regulate second heart field cell fate via Wnt secretion
Miyamoto, M.; Kannan, S.; Uosaki, H.; Kakani, T.; Murphy, S.; Andersen, P.; Kwon, C.
10.1101/2021.01.31.428968 — developmental biology — Posted on 2021-01-31
50 The role of Gdf5 in the development of the zebrafish fin endoskeleton
Waldmann, L.; Leyhr, J.; Zhang, H.; Allalou, A.; Ohman-Magi, C.; Haitina, T.
10.1101/2021.01.31.428959 — developmental biology — Posted on 2021-01-31
51 Molecular profiling of retinal pigment epithelial cell differentiation for therapeutic use
Petrus-Reurer, S.; Lederer, A. R.; Baque-Vidal, L.; Douagi, I.; Pannagel, B.; Aronsson, M.; Bartuma, H.; Wagner, M.; Andre, H.; Sundström, E.; Bhaduri, A.; Kriegstein, A.; Kvanta, A.; La Manno, G.; Lanner, F.
10.1101/2021.01.31.429014 — developmental biology — Posted on 2021-01-31
52 Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin mediated endocytosis
Anderson, R. H.; Sochacki, K. L.; Vuppula, H.; Scott, B. L.; Bailey, E. M.; Schultz, M. M.; Kerkvliet, J. G.; Taraska, J. W.; Hoppe, A. D.; Francis, K. R.
10.1101/2021.01.31.428633 — cell biology — Posted on 2021-01-31
53 Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis
Keppie, S. J.; Mansfield, J. C.; Tang, X.; Philp, C. J.; Graham, H. K.; Önnerfjord, P.; Wall, A.; McLean, C.; Winlove, C. P.; Sherratt, M. J.; Pavlovskaya, G. E.; Vincent, T. L.
10.1101/2021.01.31.428791 — cell biology — Posted on 2021-01-31
56 Multiscale mechanics and temporal evolution of vimentin intermediate filament networks
Schepers, A. V.; Lorenz, C.; Nietmann, P.; Janshoff, A. V.; Klumpp, S.; Koester, S.
10.1101/2021.01.30.428887 — biophysics — Posted on 2021-01-31
57 First 'Comprehensive' Annotation of Leucine-Rich Repeat-Containing Receptors in Rice
Gottin, C.; Dievart, A.; Summo, M.; Droc, G.; Perin, C.; Ranwez, V.; Chantret, N.
10.1101/2021.01.29.428842 — genomics — Posted on 2021-01-31
59 Lrrcc1 and Ccdc61 are conserved effectors of multiciliated cell function
Nommick, A.; Boutin, C.; Rosnet, O.; Bazellieres, E.; Thome, V.; Loiseau, E.; Viallat, A.; Kodjabachian, L.
10.1101/2021.01.30.428946 — developmental biology — Posted on 2021-01-31
60 Zebrafish spinal cord oligodendrocyte formation requires boc function
Appel, B.; Kearns, C. A.; Walker, M.; Ravanelli, A. M.; Scott, K.; Arzbecker, M. R.
10.1101/2021.01.31.429029 — developmental biology — Posted on 2021-01-31
62 SiCEP3, a C-terminally encoded peptides from Setaria italica, promotes ABA import and signaling pathway
Wu, C. A.; Ren, Y.; Wan, Y.; Xu, Q.; Zhang, S.; Yang, G.; Huang, J.; Yan, K.; Zheng, C.-C.; Zhang, L.
10.1101/2021.01.30.428944 — cell biology — Posted on 2021-01-31
66 An engineered multifunctional protein tag for advanced fluorescence imaging
Benaissa, H.; Ounoughi, K.; Aujard, I.; Fischer, E.; Goïame, R.; Nguyen, J.; Tebo, A. G.; Li, C.; Le Saux, T.; Danglot, L.; Pietrancosta, N.; Morin, X.; Jullien, L.; Gautier, A.
10.1101/2021.01.29.428635 — molecular biology — Posted on 2021-01-31
70 Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex
Spizzichino, S.; Boi, D.; Boumis, G.; Lucchi, R.; Liberati, F. R.; Capelli, D.; Montanari, R.; Pochetti, G.; Paone, A.; Rinaldo, S.; Contestabile, R.; Paiardini, A.; Tramonti, A.; Giardina, G.; Cutruzzola, F.
10.1101/2020.12.23.423904 — biochemistry — Posted on 2021-01-31
71 The Biomechanical Basis of Biased Epithelial Tube Elongation in Lung and Kidney Development
Conrad, L.; Runser, S.; Gomez, H.; Lang, C.; Dumont, M.; Sapala, A.; Kramps, L.; Michos, O.; Vetter, R.; Iber, D.
10.1101/2020.06.22.166231 — developmental biology — Posted on 2021-01-31
75 Wild to domesticates: genomes of edible diploid bananas hold traces of several undefined genepools
Sardos, J.; Breton, C.; Perrier, X.; Van Den Houwe, I.; Paofa, J.; Rouard, M.; Roux, N.
10.1101/2021.01.29.428762 — plant biology — Posted on 2021-01-31
76 STARCH SYNTHASE 4 is required for normal starch granule initiation in amyloplasts of wheat endosperm
Hawkins, E.; Chen, J.; Watson-Lazowski, A.; Ahn-Jarvis, J.; Barclay, J. E.; Fahy, B.; Hartley, M.; Warren, F. J.; Seung, D.
10.1101/2021.01.29.428798 — plant biology — Posted on 2021-01-31
84 First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays
Gao, F.; Yang, Y.; Zhu, H.; Wang, J.; Xiao, D.; Zhou, Z.; Dai, T.; Zhang, Y.; Feng, G.; Li, J.; Lin, B.; Xie, G.; Ke, Q.; Li, P.; Sheng, X.; Wang, H.; Yan, L.; Lao, C.; Li, M.; Lu, Y.; Zhao, J.; Feng, S.; Wu, D.; Du, X.
10.1101/2020.11.27.401869 — cancer biology — Posted on 2021-01-30
87 Exploring the natural origins of SARS-CoV-2
Lytras, S.; Hughes, J.; Xia, W.; Jiang, X.; Robertson, D. L.
10.1101/2021.01.22.427830 — evolutionary biology — Posted on 2021-01-30
89 mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
Wang, Z.; Schmidt, F.; Weisblum, Y.; Muecksch, F.; Barnes, C. O.; Finkin, S.; Schaefer-Babajew, D.; Cipolla, M.; Gaebler, C.; Lieberman, J. A.; Oliveira, T. Y.; Yang, Z.; Abernathy, M. E.; Huey-Tubman, K. E.; Hurley, A.; Turroja, M.; West, K. A.; Gordon, K.; Millard, K. G.; Ramos, V.; Silva, J. D.; Xu, J.; Colbert, R. A.; Patel, R.; Dizon, J. P.; Unson-O'Brien, C.; Shimeliovich, I.; Gazumyan, A.; Caskey, M.; Bjorkman, P. J.; Casellas, R.; Hatziioannou, T.; Bieniasz, P. D.; Nussenzweig, M. C.
10.1101/2021.01.15.426911 — immunology — Posted on 2021-01-30
99 Multiple Monkey Pose Estimation Using OpenPose
Blanco Negrete, S.; Labuguen, R.; Matsumoto, J.; Go, Y.; Inoue, K.-i.; Shibata, T.
10.1101/2021.01.28.428726 — neuroscience — Posted on 2021-01-30
100 Predicting multimodal MRI outcomes in children with neurodevelopmental conditions following MRI simulator training
Simhal, A. K.; Filho, J. O. A.; Segura, P.; Cloud, J.; Petkova, E.; Gallagher, R.; Castellanos, F. X.; Colcombe, S.; Milham, M. P.; Di Martino, A.
10.1101/2021.01.28.428697 — neuroscience — Posted on 2021-01-30
102 ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
Fougerat, A.; Schoiswohl, G.; Polizzi, A.; Regnier, M.; Wagner, C.; Smati, S.; Fougeray, T.; Lippi, Y.; Lasserre, F.; Melin, V.; Tramunt, B.; Alkhoury, C.; Emile, A.; Schupp, M.; Gourdy, P.; Dubot, P.; Levade, T.; Ellero-Simatos, S.; Gamet-Payrastre, L.; Panasyuk, G.; Amri, E.-Z.; Postic, C.; Wahli, W.; Loiseau, N.; Montagner, A.; Langin, D.; Lass, A.; Guillou, H.
10.1101/2021.01.28.428684 — physiology — Posted on 2021-01-30
111 Hydroxide ions amplified by water entanglement underly the mechanism of general anesthesia
Zhang, S.; Qian, H.; Li, N.; Yang, L.; Xu, Y.; Chen, R.; Lu, D.; Zhao, R.; Liu, H.; Cui, N.; Liu, Q.
10.1101/2021.01.28.428716 — animal behavior and cognition — Posted on 2021-01-30
115 The stem cell-specific protein TRIM71 inhibits maturation and activity of the pro-differentiation miRNA let-7 via two independent molecular mechanisms
Torres Fernandez, L. A.; Mitschka, S.; Ulas, T.; Dahm, K.; Becker, M.; Händler, K.; Windhausen, J.; Schultze, J. L.; Kolanus, W.
10.1101/2021.01.29.428807 — molecular biology — Posted on 2021-01-30
116 Impact of Prior Infection on Protection and Transmission of SARS-CoV-2 in Golden Hamsters
Zhang, C.; Guo, Z.; Li, N.; Cui, H.; Meng, K.; Liu, L.; Zhao, L.; Zhang, S.; Qin, C.; Liu, J.; Gao, Y.; Zhang, C.
10.1101/2021.01.30.428920 — microbiology — Posted on 2021-01-30
118 Fidelity varies in the symbiosis between a gutless marine worm and its microbial consortium
Sato, Y.; Wippler, J.; Wentrup, C.; Ansorge, R.; Sadowski, M.; Gruber-Vodicka, H. R.; Dubilier, N.; Kleiner, M.
10.1101/2021.01.30.428904 — microbiology — Posted on 2021-01-30
121 Resident Cardiac Macrophages Mediate Adaptive Myocardial Remodeling
Wong, N. R.; Mohan, J.; Kopecky, B.; Guo, S.; Du, L.; Leid, J.; Dmytrenko, O.; Luehmann, H.; Bajpai, G.; Ewald, L.; Bell, L.; Patel, N.; Lokshina, I.; Bredemeyer, A.; Weinheimer, C. J.; Negro, J.; Kovacs, A.; Morimoto, S.; Bayguinov, P. O.; Fisher, M. R.; Fitzpatrick, J. A. J.; Epelman, S.; Kreisel, D.; Sah, R.; Liu, Y.; Hu, H.; Lavine, K. J.
10.1101/2021.01.28.428724 — immunology — Posted on 2021-01-30
122 Development of a yeast-based vaccine for Theileria parva infection in cattle
Goh, S.; Kolakowski, J.; Holder, A.; Pfuhl, M.; Ngugi, D.; Ballingall, K.; Tombacz, K.; Werling, D.
10.1101/2021.01.30.428938 — immunology — Posted on 2021-01-30
124 Age-associated gut microbiota impairs hippocampus-dependent memory in a vagus dependent manner
Rei, D.; Saha, S.; Haddad, M.; Haider Rubio, A.; Ungeheuer, M.-N.; Sokol, H.; Lledo, P.-M.
10.1101/2021.01.28.428594 — neuroscience — Posted on 2021-01-30
126 Talker discontinuity disrupts attention to speech: Evidence from EEG and pupillometry
Lim, S.-J.; Carter, Y. D.; Njoroge, J. M.; Shinn-Cunningham, B. G.; Perrachione, T. K.
10.1101/2021.01.28.428718 — neuroscience — Posted on 2021-01-30
128 Spatial spread of white-nose syndrome in North America, 2006-2018
Kramer, A. M.; Mercier, A.; Maher, S. P.; Kumi-Ansu, Y.; Bowden, S.; Drake, J. M.
10.1101/2021.01.28.428526 — ecology — Posted on 2021-01-30
130 Mitophagy antagonism by Zika virus reveals Ajuba as a regulator of PINK1-Parkin signaling, PKR-dependent inflammation, and viral invasion of tissues.
Ponia, S. S.; Robertson, S. J.; McNally, K. L.; Sturdevant, G. L.; Lewis, M.; Jessop, F.; Bosio, C.; Gallegos, D.; Hay, A.; Schwartz, C.; Rosenke, R.; Saturday, G.; Martens, C.; Best, S. M.
10.1101/2021.01.29.428870 — microbiology — Posted on 2021-01-30
131 A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
Malherbe, D. C.; Kurup, D.; Wirblich, C.; Ronk, A. J.; Mire, C.; Kuzmina, N.; Shaik, N.; Periasamy, S.; Hyde, M. A.; Williams, J. M.; Shi, P.-Y.; Schnell, M. J.; Bukreyev, A.
10.1101/2021.01.29.428442 — immunology — Posted on 2021-01-30
132 SARS-CoV-2 binding and neutralizing antibody levels after vaccination with Ad26.COV2.S predict durable protection in rhesus macaques
Roozendaal, R.; Solforosi, L.; Stieh, D.; Serroyen, J.; Straetemans, R.; Wegmann, F.; Rosendahl Huber, S. K.; van der Lubbe, J. E. M.; Hendriks, J.; le Gars, M.; Dekking, L.; Czapska-Casey, D. N.; Guimera, N.; Janssen, S.; Tete, S.; Chandrashekar, A.; Mercado, N.; Yu, J.; Koudstaal, W.; Sadoff, J.; Barouch, D. H.; Schuitemaker, H.; Zahn, R.
10.1101/2021.01.30.428921 — immunology — Posted on 2021-01-30
133 Recombinant production of a functional SARS-CoV-2 spike receptor binding domain in the green algae Chlamydomonas reinhardtii
Berndt, A. J.; Smalley, T. N.; Ren, B.; Badary, A.; Sproles, A.; Fields, F.; Torres-Tiji, Y.; Heredia, V.; Mayfield, S. P.
10.1101/2021.01.29.428890 — synthetic biology — Posted on 2021-01-30
134 RGI-GOLVEN signalling promotes FLS2 abundance to regulate plant immunity
Stegmann, M.; Zecua-Ramirez, P.; Ludwig, C.; Lee, H.-S.; Peterson, B.; Nimchuk, Z. L.; Belkhadir, Y.; Hueckelhoven, R.
10.1101/2021.01.29.428839 — plant biology — Posted on 2021-01-30
135 Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity
Ozkan, A.; Stolley, D. L.; Cressman, E. N. K.; McMillin, M.; DeMorrow, S.; Yankeelov, T. E.; Rylander, M. N.
10.1101/2021.01.23.427874 — cancer biology — Posted on 2021-01-30
136 Cell lineage as a predictor of immune response in neuroblastoma
Sengupta, S.; Das, S.; Crespo, A.; Miller, B.; Sharma, B.; Zhang, S.; Dries, R.; Huang, H.; Krajewska, M.; Debruyne, D. N.; Soriano, L.; Cohen, M. A.; Versteeg, R.; Jaenisch, R.; Spranger, S.; Lieberman, J.; George, R. E.
10.1101/2021.01.29.428154 — cancer biology — Posted on 2021-01-30
137 Computational model for migration of human osteoblasts in direct current electric field
Dawson, J. E.; Sellmann, T.; Porath, K.; Bader, R.; van Rienen, U.; Appali, R.; Koehling, R.
10.1101/2020.12.15.422893 — biophysics — Posted on 2021-01-30
143 Application of a bioinformatic pipeline to RNA-seq data identifies novel virus-like sequence in human blood
Melnick, M.; Prudencio, M.; Gonzales, P.; Larocca, T. J.; Dowell, R. D.; Song, Y.; Wuu, J.; Benatar, M.; Oskarsson, B.; Petrucelli, L.; Link, C. D.
10.1101/2021.01.27.428546 — bioinformatics — Posted on 2021-01-30
144 Long-range allosteric effects - How adenine nucleotides shape the conformational landscape of the Ski2-like RNA helicase, Brr2
Absmeier, E.; Vester, K.; Ghane, T.; Burakovskiy, D.; Imhof, P.; Rodnina, M. V.; Santos, K. F.; Wahl, M. C.
10.1101/2021.01.28.428616 — biochemistry — Posted on 2021-01-30
145 The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates
Bourc'his, D.; Glaser, J.; Iranzo, J.; Borensztein, M.; Marinucci, M.; Gualtieri, A.; Jouhanneau, C.; Teissandier, A.; Gaston-Massuet, C.
10.1101/2021.01.27.428419 — molecular biology — Posted on 2021-01-30
148 P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites
Stokes, B. H.; Rubiano, K.; Dhingra, S. K.; Mok, S.; Straimer, J.; Gnadig, N. F.; Bath, J. R.; Deni, I.; Ward, K. E.; Striepen, J.; Yeo, T.; Ross, L. S.; Legrand, E.; Ariey, F.; Cunningham, C. H.; Souleymane, I. M.; Gansane, A.; Nzoumbou-Boko, R.; Ndayikunda, C.; Kabanywanyi, A. M.; Uwimana, A.; Smith, S. J.; Kolley, O.; Ndounga, M.; Warsame, M.; Leang, R.; Nosten, F.; Anderson, T.; Rosenthal, P. J.; Menard, D.; Fidock, D. A.
10.1101/2021.01.27.428390 — physiology — Posted on 2021-01-30
153 MMP12 Knockout Prevent Weight and Muscle Loss Induced by Cancer Cachexia
Jiang, L.; Yang, M.; He, S.; Li, Z.; Li, H.; Niu, T.; Xie, D.; Mei, Y.; He, X.; Wei, L.; Huang, P.; Huang, M.; Zhang, R.; Wang, L.; Li, J.
10.1101/2021.01.29.428838 — cancer biology — Posted on 2021-01-30
154 LBH is a cancer stem cell- and metastasis-driving oncogene essential for WNT stem cell function in breast cancer
Garikapati, K.; Ashad-Bishop, K.; Hong, S.; Qureshi, R.; Rieger, M. E.; Lindley, L. E.; Wang, B.; Azzam, D. J.; Khanlari, M.; Nadji, M.; Jain, C.; Kwon, D.; Ban, Y.; Gao, Z.; Chen, S. X.; Sims, A. H.; Kesmodel, S. B.; Slingerland, J. M.; Briegel, K. J.
10.1101/2021.01.29.428659 — cancer biology — Posted on 2021-01-30
155 Cell lineage as a predictor of immune response in neuroblastoma
George, R. E.; Sengupta, S.; Das, S.; Crespo, A.; Miller, B.; Sharma, B.; Zhang, S.; Dries, R.; Huang, H.; Krajewska, M.; Debruyne, D. N.; Soriano, L.; Cohen, M. A.; Versteeg, R.; Jaenisch, R.; Spranger, S.; Lieberman, J.
10.1101/2021.01.29.428154 — cancer biology — Posted on 2021-01-30
161 Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival
Gagliardi, P. A.; Dobrzynski, M.; Jacques, M.-A.; Dessauges, C.; Ender, P.; Blum, Y.; Hughes, R. M.; Cohen, A. R.; Pertz, O.
10.1101/2020.06.11.145573 — cell biology — Posted on 2021-01-30
162 The CPEB3 ribozyme modulates hippocampal-dependent memory
Chen, C. C.; Han, J.; Chinn, C. A.; Li, X.; Nikan, M.; Myszka, M.; Tong, L.; Bredy, T. W.; Wood, M. A.; Luptak, A.
10.1101/2021.01.23.426448 — molecular biology — Posted on 2021-01-30
165 Phenotypic shifts of tumor associated macrophages and STAT3 mediated suppression of myeloid derived suppressor cells drive sensitization of HER2+ tumor immunity.
Sidiropoulos, D. N.; Rafie, C.; Christmas, B. J.; Davis-Marcisak, E. F.; Sharma, G.; Bigelow, E.; Gupta, A.; Yegnasubramanian, S.; Stearns, V.; Connolly, R. M.; Gaykalova, D. A.; Kagohara, L. T.; Jaffee, E. M.; Fertig, E. J.; Roussos-Torres, E. T.
10.1101/2021.01.29.428708 — immunology — Posted on 2021-01-30
169 Deep learning to decipher the progression and morphology of axonal degeneration
Palumbo, A.; Gruening, P.; Landt, S. K.; Heckmann, L. E.; Bartram, L.; Pabst, A.; Flory, C.; Ikhsan, M.; Pietsch, S.; Schulz, R.; Kren, C.; Koop, N.; Boltze, J.; Madany Mamlouk, A.; Zille, M.
10.1101/2020.08.26.269092 — neuroscience — Posted on 2021-01-30
170 Female immunity protects from cutaneous squamous cell carcinoma
Budden, T.; Gaudy-Marqueste, C.; Craig, S.; Hu, Y.; Earnshaw, C.; Gurung, S.; Ra, A.; Akhras, V.; Shenjere, P.; Green, R.; Jamieson, L.; Lear, J.; Motta, L.; Caulin, C.; Oudit, D.; Furney, S.; Viros, A.
10.1101/2021.01.28.428489 — cancer biology — Posted on 2021-01-30
171 Non-parametric modelling of temporal and spatial counts data from RNA-seq experiments
BinTayyash, N.; Georgaka, S.; John, S.; Ahmed, S.; Boukouvalas, A.; Hensman, J.; Rattray, M.
10.1101/2020.07.29.227207 — bioinformatics — Posted on 2021-01-30
174 Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders
Blokland, G. A.; Grove, J.; Chen, C.-Y.; Cotsapas, C.; Tobet, S.; Handa, R.; Schizophrenia Working Group of the Psychiatric Genomics Consortium, ; St Clair, D.; Lencz, T.; Mowry, B. J.; Periyasamy, S.; Cairns, M. J.; Tooney, P. A.; Wu, J. Q.; Kelly, B.; Kirov, G.; Sullivan, P. F.; Corvin, A.; Riley, B. P.; Esko, T.; Milani, L.; Jönsson, E. G.; Palotie, A.; Ehrenreich, H.; Begemann, M.; Steixner-Kumar, A.; Sham, P. C.; Iwata, N.; Weinberger, D. R.; Gejman, P. V.; Sanders, A. R.; Buxbaum, J. D.; Rujescu, D.; Giegling, I.; Konte, B.; Hartmann, A. M.; Bramon, E.; Murray, R. M.; Pato, M. T.; Lee,
10.1101/2020.08.13.249813 — genetics — Posted on 2021-01-30
178 Long-term monitoring reveals topographical features and vegetation explain winter habitat use of an Arctic rodent
von Beckerath, X.; Benadi, G.; Gilg, O.; Sittler, B.; Yannic, G.; Klein, A.-M.; Eitzinger, B.
10.1101/2021.01.24.427984 — ecology — Posted on 2021-01-30
179 Telomerase Prevents Emphysema in Old Mice by Sustaining Subpopulations of Endothelial and AT2 Cells
BREAU, M.; CAYROU, C.; CHURIKOV, D.; FOUILLADE, C.; CURRAS ALONSO, S.; BAUWENS, S.; JOURQUIN, F.; BRAUD, L.; FIORE, F.; CATELLANO, R.; JOSSELIN, E.; SANCHEZ-FERRER, C.; GIOVINAZZO, G.; GILSON, E.; FLORES, I.; LONDONO-VALLEJO, A.; ADNOT, S.; GELI, V.
10.1101/2021.01.07.425708 — molecular biology — Posted on 2021-01-30
180 The ChiS-family DNA-binding domain contains a cryptic helix-turn-helix variant
Klancher, C. A.; Minasov, G.; Podicheti, R.; Rusch, D. B.; Dalia, T. N.; Satchell, K. J.; Neiditch, M. B.; Dalia, A. B.
10.1101/2020.11.18.389122 — microbiology — Posted on 2021-01-30
181 Altered basal lipid metabolism underlies the functional impairment of naive CD8+ T cells in elderly humans
Nicoli, F.; Cabral-Piccin, M.; Papagno, L.; Gallerani, E.; Folcher, V.; Dubois, M.; Clave, E.; Vallet, H.; Frere, J.; Gostick, E.; Llewellyn-Lacey, S.; Price, D.; Toubert, A.; Boddaert, J.; Caputo, A.; Gavioli, R.; Appay, V.
10.1101/2020.09.24.311704 — immunology — Posted on 2021-01-30
183 Pervasive false brain connectivity from electrophysiological signals
Pascual-Marqui, R.; Achemann, P.; Faber, P.; Kinoshita, T.; Kochi, K.; Nichida, K.; Yoshimura, M.
10.1101/2021.01.28.428625 — neuroscience — Posted on 2021-01-30
184 Fructose Metabolism Contributes to the Warburg effect
HAN, B.; Wang, L.; Zhang, J.; Wei, M.; Rajani, C.; Wei, R.; Wang, J.; Yang, H.; Carbone, M.; Xie, G.; Zhou, W.; jia, w.
10.1101/2020.06.04.132902 — cancer biology — Posted on 2021-01-30
185 The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium
Willoughby, P. M.; Allen, M.; Yu, J.; Korytnikov, R.; Chen, T.; Liu, Y.; So, I.; Macpherson, N.; Mitchell, J.; Fernandez-Gonzalez, R.; Bruce, A. E. E.
10.1101/2021.01.29.428759 — cell biology — Posted on 2021-01-29
186 Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever
Kajimura, S.; Yoneshiro, T.; Kataoka, N.; Walejko, J. M.; Ikeda, K.; Brown, Z.; Yoneshiro, M.; Crown, S. B.; White, P.; McGarrah, R.; Nakamura, K.
10.1101/2021.01.29.428776 — cell biology — Posted on 2021-01-29
190 Behavioral and brain mechanisms mediating conditioned flight behavior in rats
Totty, M. S.; Warren, N.; Huddleston, I.; Ramanathan, K. R.; Ressler, R. L.; Oleksiak, C. R.; Maren, S.
10.1101/2021.01.29.428848 — neuroscience — Posted on 2021-01-29
195 Doxorubicin Induces Senescence in Intestinal Epithelial Cells
Biruad, M.; Cortes, J.; Cray, P.; Kunzmann, G.; Mohammed, J.; Dekaney, C. M.
10.1101/2021.01.29.428764 — cell biology — Posted on 2021-01-29
196 A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics
Steenkiste, E. M.; Berndt, J. D.; Pilling, C.; Simpkins, C.; Cooper, J. A.
10.1101/2021.01.29.428899 — cell biology — Posted on 2021-01-29
197 Multi-omic Characterization of Human Tubular Epithelial Cell Response to Serum
Lidberg, K. A.; Muthusamy, S.; Adil, M.; Patel, R. S.; Wang, L.; Bammler, T. K.; Reichel, J.; Yeung, C. K.; Himmelfarb, J.; Kelly, E. J.; Akilesh, S.
10.1101/2021.01.29.428186 — cell biology — Posted on 2021-01-29
198 pUL36 de-ubiquitinase activity augments both the initiation and progression of lytic virus infection in IFN-primed cells
Mohnke, J.; Stark, I.; Fischer, M.; Grothey, A.; O'Hare, P.; Sodeik, B.; Erhard, F.; Dölken, L.; Hennig, T.
10.1101/2021.01.29.428770 — microbiology — Posted on 2021-01-29
199 Characterization of Critical Determinants of ACE2-RBD Interaction
Brown, E. E. F.; Rezaei, R.; Jamieson, T.; Dave, J.; Martin, N. T.; Singaravelu, R.; Crupi, M. J. F.; Boulton, S.; Tucker, S.; Duong, J.; Poutou, J.; Pelin, A.; Yasavoli-Sharahi, H.; Taha, Z.; Arulanandam, R.; Surendran, A.; Ghahremani, M.; Austin, B.; Matar, C.; Diallo, J.-S.; Bell, J. C.; Ilkow, C. S.; Azad, T.
10.1101/2021.01.29.428773 — microbiology — Posted on 2021-01-29
201 Experimental and Molecular Predictions of the Adjuvanticity of Snail Mucin on Hepatitis B Vaccine in Albino Mice
Joshua, P. E.; Nwauzor, C. O.; Odimegwu, D. C.; Ukachukwu, U. G.; Asomadu, R. O.; Ezeorba, T. P. C.
10.1101/2021.01.29.428769 — immunology — Posted on 2021-01-29
202 Contribution of innate and adaptive immune cells to the elimination of Salmonella enterica serotype Enteritidis infection in young broiler chickens
Meijerink, N.; van den Biggelaar, R. H. G. A.; van Haarlem, D. A.; Stegeman, A. J.; Rutten, V. P. M. G.; Jansen, C. A.
10.1101/2021.01.29.428771 — immunology — Posted on 2021-01-29
203 EEG in game user analysis: A framework for expertise classification during gameplay
Hafeez, T.; Umar Saeed, S. M.; Arsalan, A.; Anwar, S. M.; Ashraf, M. U.; Alsubhi, K.
10.1101/2021.01.29.428766 — neuroscience — Posted on 2021-01-29
204 White matter hyperintensity volume and early-onset post-stroke depression in Thai older patients
Jaroonpipatkul, C.; Onwanna, J.; Tunvirachaisakul, C.; Jittapiromsak, N.; Rakvongthai, Y.; Chutinet, A.; Supasitthumrong, T.
10.1101/2021.01.29.428768 — neuroscience — Posted on 2021-01-29
205 Movements of Mycoplasma mobile gliding machinery detected by high-speed atomic force microscopy
Kobayashi, K.; Kodera, N.; Kasai, T.; Tahara, Y. O.; Toyonaga, T.; Mizutani, M.; Fujiwara, I.; Ando, T.; Miyata, M.
10.1101/2021.01.28.428740 — microbiology — Posted on 2021-01-29
206 Long Reads Capture Simultaneous Enhancer-Promoter Methylation Status for Cell-type Deconvolution
Margalit, S.; Abramson, Y.; Sharim, H.; Manber, Z.; Bhattacharya, S.; Chen, Y. W.; Vilain, E.; Barseghyan, H.; Elkon, R.; Sharan, R.; Ebenstein, Y.
10.1101/2021.01.28.428654 — bioinformatics — Posted on 2021-01-29
207 The evolution of interdependence in a four-way mealybug symbiosis
Garber, A. I.; Kupper, M.; Laetsch, D. R.; Weldon, S. R.; Ladinsky, M. S.; Bjorkman, P. J.; McCutcheon, J. P.
10.1101/2021.01.28.428658 — evolutionary biology — Posted on 2021-01-29
213 Loss of the Long Non-coding RNA OIP5-AS1 Exacerbates Heart Failure in a Sex-Specific Manner
Zhuang, A.; Calkin, A. C.; Lau, S.; Kiriazis, H.; Donner, D.; Liu, Y.; Bond, S.; Moody, S.; Gould, E.; Colgan, T.; Ruiz-Carmona, S.; Inouye, M.; de Aguiar Vallim, T. Q.; Tarling, E.; Quaife-Ryan, G.; Hudson, J. E.; Porrello, E.; Gregorevic, P.; Gao, X.-M.; Du, X.-J.; McMullen, J. R.; Drew, B. G.
10.1101/2021.01.28.428540 — physiology — Posted on 2021-01-29
214 NR2F1 is a barrier to dissemination of early-evolved mammary cancer cells
Rodriguez Tirado, C. A.; Kale, N.; Carlini, M. J.; Shrivastava, N.; Khalil, B. D.; Bravo-Cordero, J. J.; Alexander, M.; Ji, J.; Sosa, M. S.
10.1101/2021.01.29.428822 — cancer biology — Posted on 2021-01-29
215 Information retrieval in an infodemic: the case of COVID-19 publications
Ferdowsi, S.; Borissov, N.; Kashani, E.; Vicente Alvarez, D.; Copara, J.; Gouareb, R.; Amini, P.; Teodoro, D.
10.1101/2021.01.29.428847 — bioinformatics — Posted on 2021-01-29
216 TAK1: a potential therapeutic target for retinal neovascularization
Lin, F.-L.; Wang, J.-H.; Chen, J.; Zhu, L.; Chuang, Y.-F.; Tu, L.; Ma, C.; Lama, S.; Ling, D.; Wong, R. C.-B.; Hewitt, A. W.; Tseng, C.-L.; Bui, B. V.; van Wijngaarden, P.; Dusting, G. J.; Wang, P.-Y.; Liu, G.-S.
10.1101/2021.01.29.428701 — biochemistry — Posted on 2021-01-29
221 The genomes of precision edited cloned calves show no evidence for off-target events or increased de novo mutagenesis
Jivanji, S.; Harland, C.; Cole, S.; Brophy, B.; Garrick, D.; Snell, R.; Littlejohn, M.; Laible, G.
10.1101/2021.01.28.428703 — genomics — Posted on 2021-01-29
223 Biodiversity Image Quality Metadata Augments Convolutional Neural Network Classification of Fish Species
Leipzig, J.; Bakis, Y.; Wang, X.; Elhamod, M.; Diamond, K.; Dahdul, W.; Karpatne, A.; Maga, M.; Mabee, P.; Bart, H. L.; Greenberg, J.
10.1101/2021.01.28.428644 — evolutionary biology — Posted on 2021-01-29
224 Generation of a novel Nkx6-1 Venus fusion reporter mouse line
Burtscher, I.; Tarquis-Medina, M.; Salinno, C.; Beckenbauer, J.; Bakhti, M.; Lickert, H.
10.1101/2021.01.29.428800 — developmental biology — Posted on 2021-01-29
225 Spatial organization of transcript elongation and splicing kinetics
Casill, A. D.; Haimowitz, A. J.; Kosmyna, B.; Query, C. C.; Ye, K.; Gamble, M. J.
10.1101/2021.01.28.428713 — molecular biology — Posted on 2021-01-29
234 The composition and function of Enterococcus faecalismembrane vesicles
Afonina, I.; Tien, B.; Nair, Z.; Matysik, A.; Lam, L. N.; Veleba, M.; Koh, A.; Rashid, R.; Cazenave-Gassiot, A.; Wenk, M. R.; Nyunt, S.; Kline, K.
10.1101/2021.01.28.428366 — microbiology — Posted on 2021-01-29
236 A genetic approach to dissect the role of prefoldins in Arabidopsis
Blanco-Tourinan, N.; Esteve-Bruna, D.; Serrano-Mislata, A.; Esquinas, R. M.; Resentini, F.; Forment, J.; Carrasco-Lopez, C.; Novella-Rausell, C.; Palacios, A.; Carrasco, P.; Salinas, J.; Blazquez, M. A.; Alabadi, D.
10.1101/2021.01.28.428673 — plant biology — Posted on 2021-01-29
240 Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal new biological insights
Baptista, R. P.; Li, Y.; Sateriale, A.; Brooks, K. L.; Tracey, A.; Sanders, M. J.; Ansell, B. R. E.; Jex, A. R.; Cooper, G. W.; Smith, E. D.; Xiao, R.; Dumaine, J. E.; Berriman, M.; Striepen, B.; Cotton, J. A.; Kissinger, J. C.
10.1101/2021.01.29.428682 — genomics — Posted on 2021-01-29
242 SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor
Zahradnik, J.; Marciano, S.; Shemesh, M.; Zoler, E.; Chiaravalli, J.; Meyer, B.; Rudich, Y.; Dym, O.; Elad, N.; Schreiber, G.
10.1101/2021.01.06.425392 — biochemistry — Posted on 2021-01-29
243 Development of spike receptor-binding domain nanoparticle as a vaccine candidate against SARS-CoV-2 infection in ferrets
Kim, Y.-I.; Kim, D.; Yu, K.-M.; Seo, H. D.; Lee, S.-A.; Casel, M. A. B.; Jang, S.-G.; Kim, S.; Jung, W.; Lai, C.-J.; Choi, Y. K.; Jung, J. U.
10.1101/2021.01.28.428743 — immunology — Posted on 2021-01-29
245 SUFI: An automated approach to spectral unmixing of fluorescent biological images
Sadashivaiah, V.; Tippani, M.; Page, S. C.; Kwon, S. H.; Bach, S. V.; Bharadwaj, R. A.; Hyde, T. M.; Kleinman, J. E.; Jaffe, A. E.; Maynard, K. R.
10.1101/2021.01.28.428639 — bioinformatics — Posted on 2021-01-29
249 The regulatory landscape of cells in the developing mouse cerebellum
Sarropoulos, I.; Sepp, M.; Frömel, R.; Leiss, K.; Trost, N.; Leushkin, E.; Okonechnikov, K.; Joshi, P.; Kutscher, L. M.; Cardoso-Moreira, M.; Pfister, S. M.; Kaessmann, H.
10.1101/2021.01.29.428632 — genomics — Posted on 2021-01-29
250 Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes
Fasolino, M.; Schwartz, G. W.; Golson, M.; Wang, Y. J.; Morgan, A.; Liu, C.; Schug, J.; Liu, J.; Wu, M.; Traum, D.; Kondo, A.; May, C.; Goldman, N.; Wang, W.; HPAP Consortium, ; Feldman, M.; Moore, J.; Japp, A.; Betts, M.; Faryabi, R. B.; Kaestner, K.; Naji, A.; Vahedi, G.
10.1101/2021.01.28.428598 — genomics — Posted on 2021-01-29
251 Estimating repeat spectra and genome length from low-coverage genome skims with RESPECT
Sarmashghi, S.; Balaban, M.; Rachtman, E.; Touri, B.; Mirarab, S.; Bafna, V.
10.1101/2021.01.28.428636 — genomics — Posted on 2021-01-29
252 The evolutionary making of SARS-CoV-2
Iruegas Lopez, R.; Dosch, J.; Sikora, M.; Hummer, G.; Covino, R.; Ebersberger, I.
10.1101/2021.01.29.428808 — evolutionary biology — Posted on 2021-01-29
255 Heterologous vaccination regimens with self-amplifying RNA and Adenoviral COVID vaccines induce superior immune responses than single dose vaccine regimens in mice
Spencer, A. J.; McKay, P. F.; Belij-Rammerstorfer, S.; Ulaszewska, M.; Bissett, C. D.; Hu, K.; Samnuan, K.; Sharpe, H. R.; Wright, D.; Gilbride, C.; Truby, A.; Allen, E. R.; Gilbert, S. C.; Shattock, R. J.; Lambe, T.
10.1101/2021.01.28.428665 — immunology — Posted on 2021-01-29
256 The SARS-CoV-2 Y453F mink variant displays a striking increase in ACE-2 affinity but does not challenge antibody neutralization
Bayarri-Olmos, R.; Rosbjerg, A.; Johnsen, L. B.; Helgstrand, C.; Bak-Thomsen, T.; Garred, P.; Skjoedt, M.-O.
10.1101/2021.01.29.428834 — immunology — Posted on 2021-01-29
257 Lasting effects of a single psilocybin dose on resting-state functional connectivity in healthy individuals
McCulloch, D. E.-W.; Madsen, M. K.; Stenbaek, D. S.; Kristiansen, S.; Ozenne, B.; Jensen, P. S.; Knudsen, G. M.; Fisher, P. M.
10.1101/2021.01.28.428377 — neuroscience — Posted on 2021-01-29
258 Validation of the Munich Actimetry Sleep Detection Algorithm for estimating sleep-wake patterns from activity recordings
Loock, A.-S.; Khan Sullivan, A.; Reis, C.; Paiva, T.; Gothbi, N.; Pilz, L. K.; Biller, A. M.; Molenda, C.; Vuori-Brodowski, M.; Roenneberg, T.; Winnebeck, E. C.
10.1101/2021.01.28.428574 — neuroscience — Posted on 2021-01-29
261 Pervasive false brain connectivity from electrophysiological signals
Pascual-Marqui, R.; Achemann, P.; Faber, P.; Kinoshita, T.; Kochi, K.; Nichida, K.; Yoshimura, M.
10.1101/2021.01.28.428625 — neuroscience — Posted on 2021-01-29
267 Exploring Energy Landscapes of Intrinsically Disordered Proteins: Insights into Functional Mechanisms
Oliveira Junior, A. B.; Lin, X.; Kulkarni, P.; Onuchic, J. N.; Roy, S.; Leite, V. B. P.
10.1101/2021.01.28.428595 — biophysics — Posted on 2021-01-29
268 Enhanced diffusion by reversible binding to active polymers
Lalitha Sridhar, S.; Dunagin, J.; Koo, K.; Hough, L.; Vernerey, F. J.
10.1101/2021.01.28.428690 — biophysics — Posted on 2021-01-29
270 Allosteric Regulation of the EphA2 Receptor Intracellular Region by Serine/Threonine Kinases
Lechtenberg, B. C.; Gehring, M. P.; Light, T. P.; Matsumoto, M. W.; Hristova, K.; Pasquale, E. B.
10.1101/2021.01.28.428700 — biophysics — Posted on 2021-01-29
272 Selectivity of Protein Interactions along the Aggregation Pathway of a-Synuclein
Leitao, A.; Rudolffi Soto, P.; Chappard, A.; Bhumkar, A.; Hunter, D. J. B.; Sierecki, E.; Gambin, Y.
10.1101/2021.01.29.428744 — biochemistry — Posted on 2021-01-29
274 Sex-dependent gene regulation of human atherosclerotic plaques by DNA methylation and transcriptome integration points to smooth muscle cell involvement in women.
Hartman, R. J. G.; Siemelink, M.; Haitjema, S.; Dekkers, K.; Slenders, L.; Boltjes, A.; Mokry, M.; Timmerman, N.; de Borst, G. J.; Heijmans, B.; Asselbergs, F.; Pasterkamp, G.; van der Laan, S. W.; den Ruijter, H. M.
10.1101/2021.01.28.428414 — genomics — Posted on 2021-01-29
278 H3K4 Methylation in β-cells Prevents Transcriptional Downregulation and Variance Associated with Type 2 Diabetes
Vanderkruk, B.; Maeshima, N.; Pasula, D. J.; Ann, M.; Suresh, P.; Daniel, A.; McDonald, C. L.; Luciani, D. S.; Hoffman, B.
10.1101/2021.01.28.428651 — cell biology — Posted on 2021-01-29
279 SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines
Shen, X.; Tang, H.; McDana, C.; Wagh, K.; Fischer, W.; Theiler, J.; Yoon, H.; Li, D.; Haynes, B. F.; Saunders, K. O.; Gnanakaran, S.; Hengartner, N. W.; Pajon, R.; Smith, G.; Dubovsky, F.; Glenn, G. M.; Korber, B.; Montefiori, D.
10.1101/2021.01.27.428516 — immunology — Posted on 2021-01-29
281 Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds
Haimson, B.; Meir, O.; Sudakevitz-Merzbach, R.; Elberg, G.; Friedrich, S.; Lovell, p.; Paixao, s.; Klen, R.; Mello, C. V.; Klar, A.
10.1101/2021.01.29.428748 — neuroscience — Posted on 2021-01-29
282 mTOR repression in response to amino acid starvation promotes ECM degradation through MT1-MMP endocytosis arrest
Colombero, C.; Remy, D.; Antoine, S.; Mace, A.-S.; Monteiro, P.; ElKhatib, N.; Fournier, M.; Dahmani, A.; Montaudon, E.; Montagnac, G.; Marangoni, E.; Chavrier, P.
10.1101/2021.01.29.428784 — cancer biology — Posted on 2021-01-29
284 A Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO.IL-2Rγc KO. NOD) for COVID-19
Brumeanu, T.-D.; Vir, P.; Karim, A. F.; Kar, S.; Benetiene, D.; Lok, M.; Greenhouse, J.; Putmon-Taylor, T.; Kitajewski, C.; Chung, K. K.; Pratt, K. P.; Casares, S. A.
10.1101/2020.08.19.251249 — immunology — Posted on 2021-01-29
285 Differential robustness to specific potassium channel deletions in midbrain dopaminergic neurons
Goaillard, J.-M.; Haddjeri-Hopkins, A.; Marqueze-Pouey, B.; Tapia, M.; Tell, F.; Amalric, M.
10.1101/845859 — neuroscience — Posted on 2021-01-29
286 Gradual development of non-adjacent dependency learning during early childhood
Paul, M.; Maennel, C.; van der Kant, A.; Mueller, J. L.; Hoehle, B.; Wartenburger, I.; Friederici, A. D.
10.1101/2020.09.01.277822 — neuroscience — Posted on 2021-01-29
287 UniBind: maps of high-confidence direct TF-DNA interactions across nine species
Riudavets Puig, R.; Boddie, P.; Khan, A.; Castro-Mondragon, J. A.; Mathelier, A.
10.1101/2020.11.17.384578 — genomics — Posted on 2021-01-29
288 Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses
Vila, I. K.; Chamma, H.; Steer, A.; Taffoni, C.; Reinert, L. S.; Turtoi, E.; Saccas, M.; Marines, J.; Jin, L.; Bonnefont, X.; Paludan, S. R.; Vlachakis, D.; Turtoi, A.; Laguette, N.
10.1101/2020.12.22.423950 — immunology — Posted on 2021-01-29
290 NMDAR-mediated transcriptional control of gene expression during the development of medial ganglionic eminence-derived interneurons
Mahadevan, V.; Mitra, A.; Zhang, Y.; Yuan, X.; Peltekian, A.; Chittajallu, R.; Esnault, C.; Maric, D.; Rhodes, C.; Pelkey, K. A.; Dale, R. K.; Petros, T. J.; McBain, C. J.
10.1101/2020.06.10.144295 — neuroscience — Posted on 2021-01-29
294 Differential neural circuitry behind autism subtypes with imbalanced social-communicative and restricted repetitive behavior symptoms
Bertelsen, N.; Landi, I.; Bethlehem, R. A. I.; Seidlitz, J.; Busuoli, E. M.; Mandelli, V.; Satta, E.; Trakoshis, S.; Auyeung, B.; Kundu, P.; Loth, E.; Dumas, G.; Baumeister, S.; Beckmann, C. F.; Bolte, S.; Bourgeron, T.; Charman, T.; Durston, S.; Ecker, C.; Holt, R.; Johnson, M. H.; Jones, E. J. H.; Mason, L.; Meyer-Lindenberg, A.; Moessnang, C.; Oldehinkel, M.; Persico, A.; Tillmann, J.; Williams, S. C. R.; Spooren, W.; Murphy, D. G. M.; Buitelaar, J. K.; EU-AIMS LEAP group, ; Baron-Cohen, S.; Lai, M.-C.; Lombardo, M. V.
10.1101/2020.05.08.083758 — neuroscience — Posted on 2021-01-29
295 Intrusive Experiences In Post-Traumatic Stress Disorder: Treatment Response Induces Changes In The Effective Connectivity Of The Anterior Insula
Leroy, A.; Very, E.; Birmes, P.; Szaffarczyk, S.; Lopes, R.; Faure, C.; Duhem, S.; Grandgenevre, P.; Warembourg, F.; Vaiva, G.; Jardri, R.
10.1101/2020.10.01.319269 — neuroscience — Posted on 2021-01-29
296 A mesh microelectrode array for non-invasive electrophysiology within neural organoids
McDonald, M.; Sebinger, D.; Brauns, L.; Gonzalez-Cano, L.; Menuchin-Lasowski, Y.; Mierzejewski, M.; Psathaki, O.-E.; Stumpf, A.; Wickham, J.; Rauen, T.; Schöler, H.; Jones, P. D.
10.1101/2020.09.02.279125 — neuroscience — Posted on 2021-01-29
299 A high throughput lipidomics method using scheduled multiple reaction monitoring
Bhaskar, A. K.; Naushin, S.; Ray, A.; Pradhan, S.; Adlakha, K.; Siddiqua, T. J.; Malakar, D.; Sengupta, S.
10.1101/2021.01.08.425875 — biochemistry — Posted on 2021-01-29
304 The coral symbiont Candidatus Aquarickettsia is variably abundant in threatened Caribbean acroporids and transmitted horizontally.
Baker, L. J.; Reich, H. G.; Kitchen, S. A.; Klinges, J. G.; Koch, H. R.; Baums, I. B.; Muller, E.; Vega Thurber, R.
10.1101/2021.01.28.428674 — microbiology — Posted on 2021-01-29
305 TRIPLE-NEGATIVE BREAST CANCER CELLS RECRUIT NEUTROPHILS BY SECRETING TGF-β AND CXCR2 LIGANDS
SENGUPTA, S.; Hein, L. E.; Xu, Y.; Zhang, J.; Konwerski, J.; Li, Y.; Johnson, C.; Cai, D.; Smith, J.; Parent, C. A.
10.1101/2021.01.28.428630 — immunology — Posted on 2021-01-29
306 A hetero-oligomeric remorin-receptor complex regulates plant development
Abel, N. B.; Buschle, C. A.; Hernandez-Ryes, C.; Burkart, S. S.; Deroubaix, A.-F.; Mergner, J.; Gronnier, J.; Jarsch, I. K.; Folgmann, J.; Braun, K. H.; Bayer, E.; Germain, V.; Derbyshire, P.; Menke, F. L. H.; Kemmerling, B.; Zipfel, C.; Kuester, B.; Mongrand, S.; Marin, M.; Ott, T.
10.1101/2021.01.28.428596 — plant biology — Posted on 2021-01-29
308 PredicTF: a tool to predict bacterial transcription factors in complex microbial communities.
Oliveira Monteiro, L. M.; Saraiva, J. P.; Brizola Toscan, R.; Stadler, P. F.; Silva-Rocha, R.; Nunes da Rocha, U.
10.1101/2021.01.28.428666 — bioinformatics — Posted on 2021-01-29
310 Metagenomic evidence for co-occurrence of antibiotic, biocide and metal resistance genes in pigs
Li, X.; Rensing, C.; Vestergaard, G.; Nesme, J.; Gupta, S.; Arumugam, M.; Brejnrod, A. D.; Sørensen, S. J.
10.1101/2021.01.26.428250 — bioinformatics — Posted on 2021-01-29
315 Occasional paternal inheritance of the germline-restricted chromosome in songbirds
Pei, Y.; Forstmeier, W.; Ruiz-Ruano, F. J.; Mueller, J. C.; Cabrero, J.; Camacho, J. P. M.; Alche, J. D.; Franke, A.; Hoeppner, M.; Boerno, S.; Gessara, I.; Hertel, M.; Teltscher, K.; Knief, U.; Suh, A.; Kempenaers, B.
10.1101/2021.01.28.428604 — genomics — Posted on 2021-01-28
316 A comparative baseline of coral disease across the central Red Sea
Aeby, G. S.; Shore, A.; Jensen, T.; Ziegler, M.; Work, T.; Voolstra, C.
10.1101/2021.01.28.428586 — ecology — Posted on 2021-01-28
318 Encephalitis patient derived monoclonal GABAA receptor antibodies cause catatonia and epileptic seizures
Kreye, J.; Wright, S.; van Casteren, A.; Machule, M.-L.; Reincke, S. M.; Nikolaus, M.; Stoeffler, L.; van Hoof, S.; Sanchez-Sendin, E.; Kornau, H.-C.; Kaindl, A. M.; Wilson, M. A.; Greenhill, S.; Woodhall, G.; Turko, P.; Vida, I.; Garner, C. C.; Wickel, J.; Geis, C.; Fukata, Y.; Fukata, M.; Pruess, H.
10.1101/2021.01.28.428602 — neuroscience — Posted on 2021-01-28
319 Statistical learning as reinforcement learning phenomena
Orpella, J.; Mas-Herrero, E.; Ripolles, P.; Marco-Pallares, J.; de Diego-Balaguer, R.
10.1101/2021.01.28.428582 — neuroscience — Posted on 2021-01-28
323 Intrinsic network activity in human brain organoids
Sharf, T.; van der Molen, T.; Guzman, E.; Glasauer, S. M. K.; Luna, G.; Cheng, Z.; Audouard, M.; Ranasinghe, K. G.; Kudo, K.; Nagarajan, S. S.; Tovar, K. R.; Petzold, L. R.; Hansma, P. K.; Kosik, K. S.
10.1101/2021.01.28.428643 — neuroscience — Posted on 2021-01-28
324 Amplicon sequencing of variable 16S rRNA and ITS2 regions reveal honeybee susceptibility to diseases resulted of their dietary preferences under anthropogenic landforms
Ptaszynska, A. A.; Latoch, P.; Hurd, P.; Polaszek, A.; Michalska-Madej, J.; Grochowalski, L.; Strapagiel, D.; Gnat, S.; Zaluski, D.; Gancarz, M.; Rusinek, R.; Krutmuang, P.; Martin Hernandez, R.; Higes Pascual, M.; Starosta, A. L.
10.1101/2021.01.28.428626 — zoology — Posted on 2021-01-28
325 Regulation of blood-brain barrier integrity and cognition by the microbiome-associated methylamines trimethylamine N-oxide and trimethylamine
Hoyles, L.; Pontifex, M. G.; Rodriguez-Ramiro, I.; Anis-Alavi, M. A.; Snelling, T.; Solito, E.; Fonseca, S.; Carvalho, A. L.; Carding, S. R.; Müller, M.; Glen, R. C.; Vauzour, D.; McArthur, S.
10.1101/2021.01.28.428430 — systems biology — Posted on 2021-01-28
326 Inference and validation of an integrated regulatory network of autism
Ganji, M.; Emadi-Baygi, M.; Mohammadtaheri, F.; Mirmohammadsadeghi, N.; Malek, M.; Waltemath, D.; Salehzadeh-Yazdi, A.; Nikpour, P.
10.1101/2020.06.08.139733 — systems biology — Posted on 2021-01-28
332 Th17 immunity in the colon is controlled by two novel subsets of colon-specific mononuclear phagocytes
Huang, H.-I.; Jewell, M. L.; Youssef, N.; Huang, M.-N.; Hauser, E.; Fee, B. E.; Rudemiller, N. P.; Privratsky, J.; Zhang, J. J.; Reyes, E.; Wang, D.; Taylor, G. A.; Gunn, M. D.; Ko, D. C.; Cook, D. N.; Chandramohan, V.; Crowley, S. D.; Hammer, G. E.
10.1101/2021.01.28.428597 — immunology — Posted on 2021-01-28
333 Retinal optic flow during natural locomotion
Matthis, J. S.; Muller, K. S.; Bonnen, K. L.; Hayhoe, M. M.
10.1101/2020.07.23.217893 — neuroscience — Posted on 2021-01-28
334 The landscape of PrPC biosynthesis revealed by an arrayed genome-wide interference screen
Heinzer, D.; Avar, M.; Pease, D. P.; Dhingra, A.; Yin, J.-A.; Schaper, E.; Dogancay, B.; Emmenegger, M.; Spinelli, A.; Maggi, K.; Chincisan, A.; Hornemann, S.; Heutink, P.; Aguzzi, A.
10.1101/2021.01.28.428672 — neuroscience — Posted on 2021-01-28
335 ssDNA recombineering boosts in vivo evolution of nanobodies displayed on bacterial surfaces
Al-ramahi, Y.; Nyerges, A.; Margolles, Y.; Cerdan, L.; Ferenc, G.; Pal, C.; Fernandez, L. A.; de Lorenzo, V.
10.1101/2021.01.28.428624 — synthetic biology — Posted on 2021-01-28
338 PredicTF: a tool to predict bacterial transcription factors in complex microbial communities.
Oliveira Monteiro, L. M.; Saraiva, J. P.; Nunes da Rocha, U.; Brizola Toscan, R.; Stadler, P. F.; Silva-Rocha, R.
10.1101/2021.01.28.428666 — bioinformatics — Posted on 2021-01-28
341 Identifying drivers of spatio-temporal variation in survival in four blue tit populations
Bastianelli, O.; Robert, A.; Doutrelant, C.; de Franceschi, C.; Giovannini, P.; Charmantier, A.
10.1101/2021.01.28.428563 — ecology — Posted on 2021-01-28
342 Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM
Antanasijevic, A.; Sewall, L. M.; Cottrell, C. A.; Carnathan, D. G.; Jimenez, L. E.; Ngo, J. T.; Silverman, J. B.; Groschel, B.; Georgeson, E.; Bhiman, J.; Bastidas, R.; LaBranche, C.; Allen, J. D.; Copps, J.; Perrett, H. R.; Rantalainen, K.; Cannac, F.; Yang, Y. R.; Torrents de la Pena, A.; Froes Rocha, R.; Berndsen, Z. T.; Baker, D.; King, N. P.; Sanders, R. W.; Moore, J. P.; Crotty, S.; Crispin, M.; Montefiori, D. C.; Burton, D. R.; Schief, W. R.; Silvestri, G.; Ward, A. B.
10.1101/2021.01.28.428677 — immunology — Posted on 2021-01-28
343 Altered cleavage of Caspase-1 in hepatocytes limits control of malaria in the liver
Marques-da-Silva, C.; Poudel, B.; Baptista, R. P.; Peissig, K.; Hancox, L. S.; Shiau, J. C.; Pewe, L.; Shears, M. J.; Kanneganti, T.-D.; Sinnis, P.; Kyle, D. E.; Gurung, P.; Harty, J. T.; Kurup, S. P.
10.1101/2021.01.28.427517 — immunology — Posted on 2021-01-28
349 Two softwood GUX clades are responsible for distinct glucuronic acid patterns on xylan.
Lyczakowski, J. J.; Yu, L.; Terrett, O. M.; Fleischmann, C.; Temple, H.; Thorlby, G.; Sorieul, M.; Dupree, P.
10.1101/2021.01.28.428387 — plant biology — Posted on 2021-01-28
351 A novel allele in the Arabidopsis thaliana MACPF protein CAD1 results in deregulated immune signaling
Holmes, D. R.; Bredow, M.; Thor, K.; Pascetta, S. A.; Sementchoukova, I.; Siegel, K. R.; Zipfel, C.; Monaghan, J.
10.1101/2021.01.28.428637 — plant biology — Posted on 2021-01-28
352 Pre-existing cell subpopulations in primary prostate cancers display surface fingerprint of docetaxel-resistant cells
Drapela, S.; Kvokackova, B.; Fedr, R.; Kurfurstova, D.; Morong, M.; Student, V.; van Weerden, W. M.; Puhr, M.; Culig, Z.; Bouchal, J.; Soucek, K.
10.1101/2021.01.28.428577 — cancer biology — Posted on 2021-01-28
355 Female immunity protects from cutaneous squamous cell carcinoma
Budden, T.; Gaudy-Marqueste, C.; Craig, S.; Hu, Y.; Earnshaw, C.; Gurung, S.; Ra, A.; Akhras, V.; Shenjere, P.; Green, R.; Jamieson, L.; Lear, J.; Motta, L.; Caulin, C.; Oudit, D.; Furney, S.; Viros, A.
10.1101/2021.01.28.428489 — cancer biology — Posted on 2021-01-28
362 Rostrocaudal Patterning and Neural Crest Differentiation of Human Pre-Neural Spinal Cord Progenitors in vitro
Cooper, F.; Gentsch, G. E.; Mitter, R.; Bouissou, C.; Healy, L.; Hernandez-Rodriguez, A.; Smith, J. C.; Bernardo, A. S.
10.1101/2020.06.16.155564 — developmental biology — Posted on 2021-01-28
363 Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools
Hepowit, N. L.; Macedo, J. K. A.; Young, L. E. A.; Liu, K.; Sun, R. C.; MacGurn, J.; Dickson, R. C.
10.1101/2020.10.30.362459 — cell biology — Posted on 2021-01-28
370 Anaerobic sulfur oxidation underlies adaptation of a chemosynthetic symbiont to oxic-anoxic interfaces
Paredes, G. F.; Viehboeck, T.; Lee, R.; Palatinszky, M.; Mausz, M.; Reipert, S.; Schintlmeister, A.; Maier, A.; Volland, J.-M.; Hirschfeld, C.; Wagner, M.; Berry, D.; Markert, S.; Bulgheresi, S.; Koenig, L.
10.1101/2020.03.17.994798 — microbiology — Posted on 2021-01-28
371 Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail
Dong, J.; Zost, S.; Greaney, A.; Starr, T. N.; Dingens, A. S.; Chen, E. C.; Chen, R.; Case, B.; Sutton, R.; Gilchuk, P.; Rodriguez, J.; Armstrong, E.; Gainza, C.; Nargi, R.; Binshtein, E.; Xie, X.; Zhang, X.; Shi, P.-Y.; Logue, J.; Weston, S.; McGrath, M.; Frieman, M.; Brady, T.; Tuffy, K.; Bright, H.; Loo, Y.-M.; McvTamney, P.; Esser, M.; Carnahan, R.; Diamond, M.; Bloom, J.; Crowe, J. E.
10.1101/2021.01.27.428529 — immunology — Posted on 2021-01-28
375 Evidence accumulation and associated error-related brain activity as computationally informed prospective predictors of substance use in emerging adulthood
Weigard, A. S.; Brislin, S. J.; Cope, L. M.; Hardee, J. E.; Martz, M. E.; Ly, A.; Zucker, R. A.; Sripada, C.; Heitzeg, M. M.
10.1101/2020.03.06.981035 — neuroscience — Posted on 2021-01-28
376 HDAC3 regulates senescence and lineage-specific transcriptional programs in non-small cell lung cancer
Eichner, L. J.; Curtis, S. D.; Brun, S. N.; Baumgart, J. T.; Ross, D. S.; Rymoff, T. J.; Shaw, R. J.
10.1101/2020.10.14.338590 — cancer biology — Posted on 2021-01-28
378 Interpretable prioritization of splice variants in diagnostic next-generation sequencing
Danis, D.; Jacobsen, J. O. B.; Carmody, L.; Gargano, M. A.; McMurry, J. A.; Hegde, A.; Haendel, M. A.; Valentini, G.; Smedley, D.; Robinson, P. N.
10.1101/2021.01.28.428499 — bioinformatics — Posted on 2021-01-28
379 Genome-wide DNA methylation predicts environmentally-driven life history variation in a marine fish
Cayuela, H.; Rougeux, C.; Laporte, M.; Merot, C.; Normandeau, E.; Leitwein, M.; Dorant, Y.; Praebel, K.; Kenchington, E.; Clement, M.; Sirois, P.; Bernatchez, L.
10.1101/2021.01.28.428603 — evolutionary biology — Posted on 2021-01-28
382 Nodal modulator is required to sustain endoplasmic reticulum morphology
Amaya, C.; Cameron, C. J.; Devarkar, S. C.; Gerstein, M. B.; Xiong, Y.; Schlieker, C.
10.1101/2021.01.28.428001 — cell biology — Posted on 2021-01-28
385 Vasopressin V2 is a promiscuous G protein-coupled receptor that is biased by its peptide ligands
Heydenreich, F. M.; Plouffe, B.; Rizk, A.; Milic, D.; Zhou, J.; Breton, B.; Le Gouill, C.; Inoue, A.; Bouvier, M.; Veprintsev, D.
10.1101/2021.01.28.427950 — pharmacology and toxicology — Posted on 2021-01-28
386 In-frame deletion of SPECC1L microtubule binding domain results in embryonic tissue movement and fusion defects
Goering, J. P.; Wenger, L. W.; Stetsiv, M.; Moedritzer, M.; Hall, E. G.; Isai, D. G.; Jack, B.; Umar, Z.; Rickabaugh, M. K.; Czirok, A.; Saadi, I.
10.1101/2021.01.28.428634 — developmental biology — Posted on 2021-01-28
390 DeepSVP: Integration of genotype and phenotype for structural variant prioritization using deep learning
Althagafi, A.; Alsubaie, L.; Kathiresan, N.; Mineta, K.; Aloraini, T.; Almutairi, F.; Alfadhel, M.; Gojobori, T.; Alfares, A.; Hoehndorf, R.
10.1101/2021.01.28.428557 — bioinformatics — Posted on 2021-01-28
393 Healing Tissues From the Inside Out: Infusible Biomaterial for Targeting and Treating Inflammatory Tissues via Intravascular Administration
Spang, M. T.; Lazerson, T. S.; Bhatia, S.; Corbitt, J.; Sandoval, G.; Luo, C.; Osborn, K. G.; Cabrales, P.; Kwon, E.; Contijoch, F.; Reeves, R. R.; DeMaria, A. N.; Christman, K. L.
10.1101/2020.04.10.028076 — bioengineering — Posted on 2021-01-28
395 Phage Cocktails can Prevent the Evolution of Phage-Resistant Enterococcus
Wandro, S.; Ghatbale, P.; Attai, H.; Hendrickson, C.; Samillano, C.; Suh, J.; Pride, D. T.; Whiteson, K.
10.1101/2021.01.27.428553 — microbiology — Posted on 2021-01-28
396 Early therapy with remdesivir and antibody combinations improves COVID-19 disease in mice
Martinez, D.; Schaefer, A.; Leist, S. R.; Gully, K.; Feng, J.; Bunyan, E.; Porter, D.; Cihlar, T.; Montgomery, S.; Baric, R. S.; Nussenzweig, M. C.; Sheahan, T. P.
10.1101/2021.01.27.428478 — microbiology — Posted on 2021-01-28
397 D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Viral Transmission via Enhanced Furin-mediated Spike Cleavage
Cheng, Y.-W.; Chao, T.-L.; Li, C.-L.; Wang, S.-H.; Kao, H.-C.; Tsai, Y.-M.; Wang, H.-Y.; Hsieh, C.-L.; Chen, P.-J.; Chang, S.-Y.; Yeh, S.-H.
10.1101/2021.01.27.428541 — microbiology — Posted on 2021-01-28
398 Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike protein
DiMuzio, J. M.; Heimbach, B. C.; Howanski, R. J.; Dowling, J. P.; Patel, N. B.; Henriquez, N.; Nicolescu, C.; Nath, M.; Polley, A.; Bingaman, J. L.; Smith, T.; Harman, B. C.; Robinson, M. K.; Morin, M. J.; Nikitin, P. A.
10.1101/2021.01.27.428534 — immunology — Posted on 2021-01-28
399 SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines
Shen, X.; Tang, H.; McDana, C.; Wagh, K.; Fischer, W.; Theiler, J.; Yoon, H.; Haynes, B. F.; Saunders, K. O.; Gnanakaran, S.; Hengartner, N. W.; Pajon, R.; Smith, G.; Dubovsky, F.; Glenn, G. M.; Korber, B.; Montefiori, D.
10.1101/2021.01.27.428516 — immunology — Posted on 2021-01-28
400 IL-6 blockade suppresses the blood-brain barrier disorder, leading to prevention of onset of NMOSD
Takeshita, Y.; Fujikawa, S.; Serizawa, K.; Fujisawa, M.; Matsuo, K.; Nemoto, J.; Shimizu, F.; Sano, Y.; Tomizawa-Shinohara, H.; Miyake, S.; Ransohoff, R. M.; Kanda, T.
10.1101/2021.01.28.428564 — immunology — Posted on 2021-01-28
404 Acyloxyacyl Hydrolase is a Host Determinant of Gut Microbiome-Mediated Pelvic Pain
Rahman-Enyart, A.; Yang, W.; Yaggie, R. E.; White, B.; Welge, M.; Auvil, L.; Berry, M.; Bushell, C.; Rosen, J.; Rudick, C.; Schaeffer, A. J.; Klumpp, D.
10.1101/2021.01.27.428290 — systems biology — Posted on 2021-01-28
408 Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology
Stewart, C. A.; Gay, C. M.; Ramkumar, K.; Cargill, K. R.; Cardnell, R. J.; Nilsson, M. B.; Heeke, S.; Park, E. M.; Kundu, S. T.; Diao, L.; Wang, Q.; Shen, L.; Xi, Y.; Zhang, B.; Della Corte, C. M.; Fan, Y.; Kundu, K.; Pickering, C. R.; Johnson, F. M.; Zhang, J.; Kadara, H.; Minna, J. D.; Gibbons, D. L.; Wang, J.; Heymach, J. V.; Byers, L. A.
10.1101/2020.05.28.122291 — cancer biology — Posted on 2021-01-28
409 Epigenetic state determines inflammatory sensing in neuroblastoma
Wolpaw, A. J.; Grossmann, L. D.; Dong, M. M.; Dessau, J. L.; Brafford, P. A.; Volgina, D.; Rodriguez-Garcia, A.; Uzun, Y.; Powell, D. J.; Tan, K.; Hogarty, M. D.; Maris, J. M.; Dang, C. V.
10.1101/2021.01.27.428523 — cancer biology — Posted on 2021-01-28
410 The environment topography alters the transition from single-cell populations to multicellular structures in Myxococcus xanthus
Hernandez Ramos, K. C.; Rodriguez-Sanchez, E.; Arias Del Angel, J. A.; Arzola, A. V.; Benitez, M.; Escalante, A. E.; Franci, A.; Volpe, G.; Rivera-Yoshida, N.
10.1101/2021.01.27.428527 — biophysics — Posted on 2021-01-28
413 The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins
Tugaeva, K. V.; Hawkins, D. E. D. P.; Smith, J. L. R.; Bayfield, O. W.; Ker, D.-S.; Sysoev, A. A.; Klychnikov, O. I.; Antson, A. A.; Sluchanko, N. N.
10.1101/2020.12.26.424450 — biochemistry — Posted on 2021-01-28
415 Games of risk and reward in carnivore communities
Ruprecht, J.; Eriksson, C. E.; Forrester, T. D.; Spitz, D. B.; Clark, D. A.; Wisdom, M. J.; Bianco, M.; Rowland, M. M.; Smith, J. B.; Johnson, B. K.; Levi, T.
10.1101/2021.01.27.428481 — ecology — Posted on 2021-01-28
416 The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release
Jabbour, L.; Nguyen, T.; Gadet, R.; Lohez, O.; Mikaelian, I.; Gonzalo, P.; Luyten, T.; Chalabi, M.; Bultynck, G.; Rimokh, R.; Gillet, G.; Popgeorgiev, N.
10.1101/2021.01.27.428229 — cell biology — Posted on 2021-01-28
417 Generation of a New Frizzled 2 Flox Mouse Model to Clarify Its Role in Development
Michalski, M. N.; Diegel, C. R.; Zhong, Z. A.; Suino-Powell, K.; Blazer, L.; Adams, J.; VAI Vivarium and Transgenics Core, ; Beddows, I.; Melcher, K.; Sidhu, S. S.; Angers, S.; Williams, B. O.
10.1101/2021.01.27.428341 — cell biology — Posted on 2021-01-28
418 Golden hamster piRNAs are necessary for early embryonic development and establishment of spermatogonia
Loubalova, Z.; Fulka, H.; Horvat, F.; Pasulka, J.; Malik, R.; Hirose, M.; Ogura, A.; Svoboda, P.
10.1101/2021.01.27.428513 — molecular biology — Posted on 2021-01-28
419 Single-cell immune profiling reveals the impact of antiretroviral therapy on HIV-1-induced immune dysfunction, T cell clonal expansion, and HIV-1 persistence in vivo
Collora, J. A.; Pinto-Santini, D.; Pasalar, S.; Ravindra, N.; Ganoza, C.; Lama, J.; Alfaro, R.; Chiarella, J.; Spudich, S.; van Dijk, D.; Duerr, A.; Ho, Y.-C.
10.1101/2021.01.27.428491 — immunology — Posted on 2021-01-28
421 Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia
Guisle, I.; Petry, S.; Morin, F.; Kerauden, R.; Whittington, R. A.; Calon, F.; Hebert, S.; Planel, E.
10.1101/2021.01.27.428475 — neuroscience — Posted on 2021-01-28
427 Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses.
Munoz-Lobato, F.; Benedetti, K. L.; Farah, F.; Chandra, R.; Bokka, A.; Brueggemann, C.; Saifuddin, F. M.; Nordquist, S. K.; Li, J.; Chang, E.; Varshney, A.; Jiminez, V.; Andersen, K. E.; Baradwaj, A.; Miller, J. M.; Dunn, R. L.; Tsujimoto, B.; Duong, A.; Tran, A.; Zuazo, C. E.; Churgin, M.; Fang-Yen, C.; Bremer, M.; Kato, S.; VanHoven, M.; L'Etoile, N.
10.1101/2020.11.24.395228 — neuroscience — Posted on 2021-01-28
428 Proteomic portraits reveal evolutionarily conserved and divergent responses to spinal cord injury
Skinnider, M. A.; Rogalski, J.; Tigchelaar, S.; Manouchehri, N.; Prudova, A.; Jackson, A. M.; Nielsen, K.; Jeong, J.; Chaudhary, S.; Shortt, K.; Gallagher-Kurtzke, Y.; So, K.; Fong, A.; Gupta, R.; Okon, E. B.; Rizzuto, M. A.; Dong, K.; Streijger, F.; Belanger, L.; Ritchie, L.; Tsang, A.; Christie, S.; Mac-Thiong, J.-M.; Bailey, C.; Ailon, T.; Charest-Morin, R.; Dea, N.; Wilson, J. R.; Dhall, S.; Paquette, S.; Street, J.; Fisher, C. G.; Dvorak, M. F.; Shannon, C. P.; Borchers, C.; Balshaw, R.; Foster, L. J.; Kwon, B. K.
10.1101/2021.01.27.428528 — neuroscience — Posted on 2021-01-28
429 Genotype and age influence cortical-FKBP5 at multiple regulatory and single-cell-type levels in severe psychiatric disorders
Matosin, N.; Arloth, J.; Martinelli, S.; Czamara, D.; Maitra, M.; Halldorsdottir, T.; Cruceanu, C.; Kaul, D.; Gassen, N.; Hafner, K.; Mueller, N.; Worf, K.; Rehawi, G.; Nagy, C.; Scarr, E.; Tao, R.; Jaffe, A. E.; Arzberger, T.; Falkai, P.; Kleinmann, J.; Weinberger, D.; Mechawar, N.; Schmitt, A.; Dean, B.; Turecki, G.; Hyde, T. M.; Binder, E.
10.1101/2021.01.27.428487 — neuroscience — Posted on 2021-01-28
431 The GASA Gene Family in Theobroma cacao: Genome Wide Identification and Expression Analyses
Abdullah, ; Faraji, S.; Mehmood, F.; Malik, H. M. T.; Ahmed, I.; Heidari, P.; Poczai, P.
10.1101/2021.01.27.425041 — plant biology — Posted on 2021-01-28
433 The MEMIC: An ex vivo system to model the complexity of the tumor microenvironment
Janska, L.; Anandi, L.; Kirchberger, N. C.; Marinkovic, Z. S.; Schachtner, L. T.; Guzelsoy, G.; Carmona-Fontaine, C.
10.1101/2021.01.27.428324 — cancer biology — Posted on 2021-01-28
434 A noncanonical FLT3 gatekeeper mutation disrupts gilteritinib binding and confers resistance
Joshi, S. K.; Sharzehi, S.; Pittsenbarger, J.; Bottomly, D.; Tognon, C. E.; McWeeney, S.; Druker, B.; Traer, E.
10.1101/2021.01.27.428336 — cancer biology — Posted on 2021-01-28
435 Ultraviolet light-induced collagen degradation inhibits melanoma invasion
Budden, T.; Gaudy-Marqueste, C.; Porter, A.; Kay, E.; Gurung, S.; Earnshaw, C.; Roeck, K.; Craig, S.; Traves, V.; Krutmann, J.; Muller, P.; Motta, L.; Zanivan, S.; Malliri, A.; Furney, S.; Nagore, E.; Viros, A.
10.1101/2021.01.27.428482 — cancer biology — Posted on 2021-01-28
438 MS2AI: Automated repurposing of public peptide LC-MS data for ML applications
Rehfeldt, T. G.; Krawczyk, K.; Bogebjerg, M.; Schwämmle, V.; Röttger, R.
10.1101/2021.01.27.428375 — bioinformatics — Posted on 2021-01-28
441 Mechanism of activation and regulation of Deubiquitinase activity in MINDY1 and MINDY2
Abdul Rehman, S. A.; Armstrong, L. A.; Lange, S. M.; Kristariyanto, Y. A.; Grawert, T. W.; Knebel, A.; Svergun, D.; Kulathu, Y.
10.1101/2021.01.27.428544 — biochemistry — Posted on 2021-01-28
443 MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution
Gallardo, C. M.; Wang, S.; Montiel-Garcia, D. J.; Little, S. J.; Smith, D. M.; Routh, A. L.; Torbett, B. E.
10.1101/2021.01.27.428469 — genomics — Posted on 2021-01-28
449 Comprehensive in situ mapping of human cortical transcriptomic cell types
Mattsson Langseth, C.; Gyllborg, D.; Miller, J. A.; Close, J. L.; Long, B.; Lein, E. S.; Hilscher, M. M.; Nilsson, M.
10.1101/2021.01.28.428548 — neuroscience — Posted on 2021-01-28
451 Differential chemoarchitecture of Purkinje neurons contributes to intrinsic firing properties
Brandenburg, C.; Smith, L. A.; Kilander, M. B.; Bridi, M. S.; Lin, Y.-C.; Huang, S.; Blatt, G. J.
10.1101/2021.01.28.428615 — neuroscience — Posted on 2021-01-28
454 Improved spatio-temporal measurements of visually evoked fields using optically-pumped magnetometers
Gialopsou, A.; Abel, C.; James, T. M.; Coussens, T.; Bason, M. G.; Puddy, R.; Di Lorenzo, F.; Rolfs, K.; Voigt, J.; Sander, T.; Cercignani, M.; Kruger, P.
10.1101/2021.01.27.428396 — neuroscience — Posted on 2021-01-28
455 Behavioral fingerprints predict insecticide and anthelmintic mode of action
McDermott-Rouse, A.; Minga, E.; Barlow, I.; Feriani, L.; Harlow, P. H.; Flemming, A. J.; Brown, A.
10.1101/2021.01.27.428391 — systems biology — Posted on 2021-01-28
457 Machine Translation between paired Single Cell Multi Omics Data
Martinez-de-Morentin, X.; Khan, S.; Lehmann, R.; Tegner, J.; Gomez-Cabrero, D.
10.1101/2021.01.27.428400 — bioinformatics — Posted on 2021-01-28
458 Unique Protein Interaction Networks Define The Chromatin Remodeling Module of The NuRD Complex
Sharifi Tabar, M.; Giardina, C.; Feng, Y.; Francis, H.; Moghaddassani, H.; Low, J. K. K.; Mackay, J. P.; Bailey, C. G.; Rasko, J. E. J.
10.1101/2021.01.27.428018 — biochemistry — Posted on 2021-01-28
460 Oscillations support co-firing of neurons in the service of human memory formation
Roux, F.; Parish, G. M.; Chelvarajah, R.; Rollings, D. T.; Sawlani, V.; Hamer, H.; Gollwitzer, S.; Kreiselmeyer, G.; ter Wal, M. J.; Kolibius, L.; Staresina, B.; Wimber, M.; Self, M. W.; Hanslmayr, S.
10.1101/2021.01.28.428480 — neuroscience — Posted on 2021-01-28
461 Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics
George, B.; Paul, A. M.; Mukundan, P. P.; Amjesh, R.; Leitzel, K.; Ali, S. M.; Sandiford, O.; Lipton, A.; Rameshwar, P.; Hortobagyi, G. N.; Pillai, R. M.; Kumar, R.
10.1101/840975 — cancer biology — Posted on 2021-01-28
462 Revealing the human mucinome
Malaker, S. A.; Riley, N. M.; Shon, J.; Pedram, K.; Krishnan, V.; Dorigo, O.; Bertozzi, C. R.
10.1101/2021.01.27.428510 — biochemistry — Posted on 2021-01-28
463 A novel adhesive complex at the base of intestinal microcilli
Ebnet, K. T.; Hartmann, C.; Thüring, E.-M.; Michels, B. E.; Pajonczyk, D.; Leussink, S.; Greune, L.; Brinkmann, F.; Glaesner-Ebnet, M.; Wardelmann, E.; Zobel, T.; Schmidt, M. A.; Gerke, V.
10.1101/2021.01.25.428038 — cell biology — Posted on 2021-01-28
465 Elevation-related climate trends dominate fungal co-occurrence patterns on Mt. Norikura, Japan
Yang, Y.; Shi, Y.; kerfahi, D.; Ogwu, M. C.; Wang, J.; Dong, K.; Takahashi, K.; Moroenyane, I.; Adams, J. M.
10.1101/2021.01.25.428196 — microbiology — Posted on 2021-01-28
466 Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice
Silva-Filho, J. L.; The Zika-Unicamp Network, ; Oliveira, L. G.; Monteiro, L.; Parise, P. L.; Zanluqui, N. G.; Polonio, C. M.; Freitas, C. L.; Toledo-Teixeira, D. A.; Souza, W. M.; Bittencourt, N.; Amorim, M. R.; Forato, J.; Muraro, S. P.; Souza, G. F.; Martini, M. C.; Bispos-dos-Santos, K.; Judice, C. C.; Costa, M. L.; Angerami, R. N.; Freitas, A. R. R.; Resende, M. R.; Garcia, M. T.; Moretti, M. L.; Renia, L.; Ng, L. F.; Rothlin, C. V.; Costa, F. T.; Peron, J. P. S.; Proenca-Modena, J. L.
10.1101/2021.01.27.428402 — microbiology — Posted on 2021-01-28
467 Evaluation of the rapidBACpro(R) II kit for the rapid identification of microorganisms directly from blood cultures using MALDI-TOF MS
Oviano, M.; Ingebretsen, A.; Steffensen, A. K.; Croxatto, A.; Prod'hom, G.; Quiroga, L.; Bou, G.; Greub, G.; Rodriguez-Sanchez, B.
10.1101/2021.01.25.428200 — microbiology — Posted on 2021-01-28
469 Genome-wide analysis of mitochondrial DNA copy number reveals multiple loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation
Longchamps, R. J.; Yang, S. Y.; Castellani, C. A.; Shi, W.; Lane, J.; Grove, M. L.; Bartz, T. M.; Sarnowski, C.; Burrows, K.; Guyatt, A. L.; Gaunt, T. R.; Kacprowski, T.; Yang, J.; De, P. L.; Yu, L.; CHARGE Aging and Longevity Group, ; Bergman, A.; Xia, R.; Fornage, M.; Feitosa, M. F.; Wojczynski, M. K.; Kraja, A. T.; Province, M. A.; Amin, N.; Rivadeneira, F.; Tiemeier, H.; Uitterlinden, A. G.; Broer, L.; Van, J.; Van, C.; Raffield, L. M.; Lange, L.; Rich, S. S.; Lemaitre, R. N.; Goodarzi, M. O.; Sitlani, C. M.; Mak, A. C.; Bennett, D. A.; Rodriguez, S.; Murabito, J. M.; Lunetta, K. L.; Soto
10.1101/2021.01.25.428086 — genetics — Posted on 2021-01-28
471 Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted heart
Hesse, J.; Owenier, C.; Lautwein, T.; Zalfen, R.; Weber, J. F.; Ding, Z.; Alter, C.; Lang, A.; Grandoch, M.; Gerdes, N.; Fischer, J. W.; Klau, G. W.; Dieterich, C.; Köhrer, K.; Schrader, J.
10.1101/2021.01.26.428270 — cell biology — Posted on 2021-01-28
473 The human SKI complex prevents DNA-RNA hybrid-associated telomere instability
Herrera-Moyano, E.; Porreca, R. M.; Ranjha, L.; Skourti, E.; Gonzalez Franco, R.; Sun, Y.; Stylianakis, M.; Montoya, A.; Kramer, H.; Vannier, J.-B.
10.1101/2020.05.20.107144 — molecular biology — Posted on 2021-01-28
474 Dengue emergence in the temperate Argentinian province of Santa Fe, 2009-2020.
LOPEZ, M. S.; JORDAN, D. I.; BLATTER, E.; WALKER, E.; GOMEZ, A. A.; MULLER, G. V.; MENDICINO, D.; ROBERT, M. A.; ESTALLO, E. L.
10.1101/2020.08.11.246272 — microbiology — Posted on 2021-01-28
477 The post-translational modification landscape of commercial beers
Kerr, E. D.; Caboche, C. H.; Pegg, C. L.; Phung, T. K.; Gonzalez Viejo, C.; Fuentes, S.; Howes, M. T.; Howell, K.; Schulz, B. L.
10.1101/2021.01.27.427706 — biochemistry — Posted on 2021-01-28
480 Conductance-Based Structural Brain Connectivity in Aging and Dementia
Frau-Pascual, A.; Augustinak, J.; Varadarajan, D.; Yendiki, A.; Salat, D. H.; Fischl, B.; Aganj, I.
10.1101/2020.09.15.298331 — neuroscience — Posted on 2021-01-27
481 Pore structure controls stability and molecular flux in engineered protein cages
Adamson, L.; Tasneem, N.; Andreas, M. P.; Close, W.; Szyszka, T. N.; Jenner, E.; Young, R.; Cheah, L. C.; Norman, A.; Sainsbury, F.; Giessen, T. W.; Lau, Y. H.
10.1101/2021.01.27.428512 — synthetic biology — Posted on 2021-01-27
482 Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy
Bai, P.; Li, Y.; Zhou, Q.; Xia, J.; Wei, P.-C.; Deng, H.; Wu, M.; Chan, S. K.; Kappler, J. W.; Zhou, Y.; Tran, E.; Marrack, P.; Yin, L.
10.1101/700732 — cancer biology — Posted on 2021-01-27
485 Live-cell imaging reveals the spatiotemporal organization of endogenous RNA polymerase II phosphorylation at a single gene
Forero, L. S.; Raymond, W.; Handa, T.; Saxton, M.; Morisaki, T.; Kimura, H.; Bertrand, E.; Munsky, B.; Stasevich, T. J.
10.1101/2020.04.03.024414 — molecular biology — Posted on 2021-01-27
489 Environmental and genetic factors cause atypical development of vocalizations in neonatal mice: analyses of neurodevelopmental disorder models using a novel unsupervised machine learning approach
Mai, L.; Kimura, R.; Hori, K.; Inada, H.; Kanno, K.; Matsuda, T.; Tachibana, R. O.; Yoshizaki, K.; Tucci, V.; Komaki, F.; Hoshino, M.; Osumi, N.
10.1101/738781 — neuroscience — Posted on 2021-01-27
490 Connectome Gradient Dysfunction in Major Depression and Its Association with Gene Expression Profiles
Xia, M.; Liu, J.; Mechelli, A.; Sun, X.; Ma, Q.; Wang, X.; Wei, D.; Chen, Y.; Liu, B.; Huang, C.-C.; Zheng, Y.; Wu, Y.; Chen, T.; Cheng, Y.; Xu, X.; Gong, Q.; Si, T.; Qiu, S.; Lin, C.-P.; Cheng, J.; Tang, Y.; Wang, F.; Qiu, J.; Xie, P.; Li, L.; He, Y.; DIDA-Major Depressive Disorder Working Group,
10.1101/2020.10.24.352153 — neuroscience — Posted on 2021-01-27
492 SARS-CoV-2 emerging complexity
Bertacchini, F.; Bilotta, E.; Pantano, P. S.
10.1101/2021.01.27.428384 — bioinformatics — Posted on 2021-01-27
494 Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos
Guo, L.; Bloom, J. S.; Sykes, S.; Huang, E.; Kashif, Z.; Pham, E.; Ho, K.; Alcaraz, A.; Xiao, X. G.; Duarte-Vogel, S.; Kruglyak, L.
10.1101/2020.12.18.423549 — genetics — Posted on 2021-01-27
495 Local adaptation and archaic introgression shape global diversity at human structural variant loci
Yan, S. M.; Sherman, R. M.; Taylor, D. J.; Nair, D. R.; Bortvin, A. N.; Schatz, M. C.; McCoy, R. C.
10.1101/2021.01.26.428314 — evolutionary biology — Posted on 2021-01-27
496 A Human Accelerated Region is a Leydig cell GLI2 Enhancer that Affects Male-Typical Behavior
Reiter, J.; Norman, A. R.; Ahituv, N. R.; Ryu, A. H.; Jamieson, K.; Shen, Y.; Pollard, K. S.; Thomas, S.
10.1101/2021.01.27.428524 — evolutionary biology — Posted on 2021-01-27
498 Transcriptome profile of the zebrafish atrioventricular canal reveals molecular signatures of pacemaker and valve mesenchyme
Abu Nahia, K.; Migdał, M.; Quinn, A. T.; Poon, K. L.; Łapinski, M.; Sulej, A.; Pawlak, M.; Bugajski, Łukasz; Piwocka, K.; Brand, T.; Kohl, P.; Korzh, V.; Winata, C.
10.1101/2021.01.27.428386 — developmental biology — Posted on 2021-01-27
499 Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection
Sohail, A.; Iqbal, A.; Sahini, N.; Tantawy, M.; Winterhoff, M.; Geffers, R.; Ebensen, T.; Schughart, K.; Pils, M.; Chen, F.; Guzman, C. A.; Preusse, M.; Pleschka, S.; Mostafa, A.; Falk, C.; Michelucci, A.; Pessler, F.
10.1101/2021.01.20.427392 — immunology — Posted on 2021-01-27
500 Architecture of the Neuro-Glia-Vascular System
Zisis, E.; Keller, D.; Kanari, L.; Arnaudon, A.; Gevaert, M.; Delemontex, T.; Coste, B.; Foni, A.; Abdellah, M.; Cali, C.; Hess, K.; Magistretti, P. J.; Schürmann, F.; Markram, H.
10.1101/2021.01.19.427241 — neuroscience — Posted on 2021-01-27
503 Towards Similarity-based Differential Diagnostics For Common Diseases
Slater, L. T.; Karwath, A.; Williams, J. A.; Russell, S.; Makepeace, S.; Carberry, A.; Hoehndorf, R.; Gkoutos, G. V.
10.1101/2021.01.26.428269 — bioinformatics — Posted on 2021-01-27
505 Eya1-dependent homeostasis of morphogenetic territories during collective cell migration
Lopez-Schier, H.; Hammerschmidt, M.; Kawakami, K.; Pinto Teixeira, F.; Miranda Rodriguez, J. R.; Borges, A.; Wibowo, I.
10.1101/2021.01.27.428404 — developmental biology — Posted on 2021-01-27
506 A Single Cell Atlas of Lung Development
Negretti, N. M.; Plosa, E. J.; Benjamin, J. T.; Schuler, B. A.; Habermann, A. C.; Jetter, C. S.; Taylor, C. J.; Gulleman, P.; Nichols, D.; Matlock, B. K.; Guttentag, S. H.; Blackwell, T. S.; Banovich, N. E.; Kropski, J. A.; Sucre, J. M.
10.1101/2021.01.21.427641 — developmental biology — Posted on 2021-01-27
508 Structural insight into Pichia pastoris fatty acid synthase
Snowden, J. S.; Alzahrani, J.; Sherry, L.; Stacey, M.; Rowlands, D. J.; Ranson, N. A.; Stonehouse, N. J.
10.1101/2021.01.27.428426 — microbiology — Posted on 2021-01-27
509 Astrocytic VMAT2 in the developing prefrontal cortex is required for normal grooming behavior in mice
Bezzi, P.; Petrelli, F.; Zehnder, T.; Pucci, L.; Cali, C.; Bondiolotti, B. M.; Molinero Perez, A.; Dallerac, G.; Deglon, N.; Giros, B.; Magara, F.; Magrassi, L.; Mothet, J.-P.; Simmler, L.
10.1101/2021.01.27.428434 — neuroscience — Posted on 2021-01-27
510 Conductance-Based Structural Brain Connectivity in Aging and Dementia
Frau-Pascual, A.; Augustinak, J.; Varadarajan, D.; Yendiki, A.; Salat, D. H.; Fischl, B.; Aganj, I.
10.1101/2020.09.15.298331 — neuroscience — Posted on 2021-01-27
512 Immunogenomic profile of colorectal cancer response to immune checkpoint blockade
Bortolomeazzi, M.; Keddar, M. R.; Montorsi, L.; Acha-Sagredo, A.; Benedetti, L.; Temelkovski, D.; Choi, S.; Petrov, N.; Todd, K.; Wai, P.; Kohl, J.; Denner, T.; Nye, E.; Goldstone, R.; Ward, S.; Wilson, G. A.; Al Bakir, M.; Swanton, C.; John, S.; Miles, J.; Larijani, B.; Kunene, V.; Fontana, E.; Arkenau, H.-T.; Parker, P. J.; Rodriguez-Justo, M.; Shiu, K.-K.; Spencer, J.; Ciccarelli, F. D.
10.1101/2020.12.15.422831 — cancer biology — Posted on 2021-01-27
514 Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms
Gogl, G.; Tugaeva, K. V.; Eberling, P.; Kostmann, C.; Trave, G.; Sluchanko, N. N.
10.1101/2020.07.24.220376 — biochemistry — Posted on 2021-01-27
515 Discovery of an IKK2 Site that Allosterically Controls Its Activation
Hotchkiss, S. J.; Mulero, M. C.; Chan, G. J.; Biswas, T.; Polley, S.; Ohn, C.; Konduri, S.; Demir, O.; Amaro, R. E.; Ghosh, G.
10.1101/2021.01.27.428502 — biochemistry — Posted on 2021-01-27
522 Activation of the Crtc2/Creb1 transcriptional network in skeletal muscle enhances weight loss during intermittent fasting
Bruno, N.; Nwachukwu, J. C.; Srinivasan, S.; Sturgill, D.; Hager, G.; Hurst, S.; Sheu, S.-S.; Conkright, M.; Nettles, K. W.
10.1101/2020.06.27.175323 — physiology — Posted on 2021-01-27
523 Cancer methylomes characterization enabled by Rocker-meth
Benelli, M.; Franceschini, G. M.; Magi, A.; Romagnoli, D.; Biagioni, C.; Migliaccio, I.; Malorni, L.; Di Leo, A.; Demichelis, F.
10.1101/2020.10.09.332759 — cancer biology — Posted on 2021-01-27
524 AMPK-dependent phosphorylation is required for transcriptional activation of TFEB/TFE3
Paquette, M.; El-Houjeiri, L.; Zirden, L. C.; Puustinen, P.; Blanchette, P.; Jeong, H.; Dejgaard, K.; Siegel, P. M.; Pause, A.
10.1101/2021.01.27.428292 — cancer biology — Posted on 2021-01-27
526 Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance
Cagiada, M.; Johansson, K. E.; Valanciute, A.; Nielsen, S. V.; Hartmann-Petersen, R.; Yang, J. J.; Fowler, D. M.; Stein, A.; Lindorff-Larsen, K.
10.1101/2020.09.28.317040 — biophysics — Posted on 2021-01-27
527 Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals fastercommitment under dynamic conditions
Silva, T. P.; Sousa-Luis, R.; Fernandes, T. G.; Bekman, E. P.; Rodrigues, C. A. V.; Vaz, S. H.; Moreira, L. M.; Hashimura, Y.; Jung, S.; Lee, B.; Carmo-Fonseca, M.; Cabral, J. M. S.
10.1101/2021.01.27.428468 — bioengineering — Posted on 2021-01-27
528 Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk loci
Hong, T.; Parameswaran, S.; Donmez, O.; Miller, D.; Forney, C.; Lape, M.; Saint Just Ribeiro, M.; Edsall, L. E.; Liang, J.; Magnusen, A.; Miller, W.; Chepelev, I.; Harley, J. B.; Zhao, B.; Kottyan, L. C.; Weirauch, M. T.
10.1101/2020.04.15.043612 — genomics — Posted on 2021-01-27
535 A novel sodium signaling complex regulates uterine activity
Ferreira, J. J.; Amazu, C.; Puga-Molina, L. C.; Ma, X.; England, S. K.; Santi, C. M.
10.1101/2020.07.31.229138 — cell biology — Posted on 2021-01-27
537 Tau aggregates are RNA-protein assemblies that mis-localize multiple nuclear speckle components
Lester, E.; Parker, R.; Ooi, F. K.; Bakkar, N.; Ayers, J.; Woerman, A. L.; Wheeler, J. R.; Bowser, R.; Carlson, G. A.; Prusiner, S. B.
10.1101/2021.01.27.428450 — molecular biology — Posted on 2021-01-27
539 Commensal bacterial-derived retinoic acid primes host defense to intestinal infection
Alenghat, T.; Woo, V.; Eshleman, E. M.; Whitt, J.; Hashimoto-Hill, S.; Wu, S.-e.; Engleman, L.; Rice, T.; Karns, R.; Vallance, B. A.
10.1101/2021.01.27.428280 — microbiology — Posted on 2021-01-27
541 Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium
Canfield, G. S.; Chatterjee, A.; Espinosa, J.; Mangalea, M. R.; Sheriff, E. K.; Keidan, M.; McBride, S. W.; McCollister, B. D.; Hang, H. C.; Duerkop, B. A.
10.1101/2020.09.22.309401 — microbiology — Posted on 2021-01-27
543 Seroprevalence of Toxoplasma gondii among sylvatic rodents in Poland
Grzybek, M.; Antolova, D.; Tolkacz, K.; Alsarraf, M.; Behnke-Borowczyk, J.; Nowicka, J.; Paleolog, J.; Biernat, B.; Behnke, J. M.; Bajer, A.
10.1101/2021.01.27.428493 — microbiology — Posted on 2021-01-27
544 Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer.
Overacre-Delgoffe, A. E.; Cillo, A. R.; Bumgarner, H. J.; Burr, A. H.; Tometich, J. T.; Bhattacharjee, A.; Bruno, T. C.; Vignali, D. A.; Hand, T.
10.1101/2021.01.27.428417 — immunology — Posted on 2021-01-27
545 Nfkbid is required for immunity and antibody responses to Toxoplasma gondii
Souza, S. P.; Splitt, S. D.; Alvarez, J. A.; Wilson, J.; Wizzard, S.; Luo, Z.; Baumgarth, N.; Jensen, K.
10.1101/2020.06.26.174151 — immunology — Posted on 2021-01-27
549 Suberin plasticity to developmental and exogenous cues is regulated by a set of MYB transcription factors
Shukla, V.; Han, J.-P.; Cléard, F.; Legendre-Lefebvre, L.; Gully, K.; Flis, P.; Berhin, A.; Andersen, T. G.; Salt, D. E.; Nawrath, C.; Barberon, M.
10.1101/2021.01.27.428267 — plant biology — Posted on 2021-01-27
550 AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa
Xue, Y.; Wang, S. K.; Rana, P.; West, E. R.; Hong, C. M.; Feng, H.; Wu, D. M.; Cepko, C. L.
10.1101/2021.01.27.428411 — physiology — Posted on 2021-01-27
551 Inhibition of HSP90 reversed STAT3 mediated muscle wasting induced by cancer cachexia
Wang, H.; Niu, M.; Song, S.; Su, Z.; Wei, L.; Li, L.; Pu, W.; Zhao, C.; Ding, Y.; Cao, W.; Gao, Q.
10.1101/2021.01.27.428420 — pathology — Posted on 2021-01-27
552 MOLECULAR LANDSCAPE OF OLD AGE MELANOMA BY SURVIVAL AND IMMUNOTHERAPY RESPONSE
Smith, S. P.; Nagore, E.; Budden, T.; Kumar, R.; Marais, R.; Gaudy-Marqueste, C.; Viros, A.
10.1101/2021.01.27.428444 — cancer biology — Posted on 2021-01-27
554 CloudReg: Automatic Terabyte-Scale Cross-Modal Brain Volume Registration
Chandrashekhar, V.; Tward, D. J.; Crowley, D. G.; Crow, A. K.; Wright, M. A.; Hsueh, B. Y.; Gore, F.; Machado, T. A.; Branch, A.; Rosenblum, J. S.; Deisseroth, K.; Vogelstein, J. T.
10.1101/2021.01.26.428355 — bioengineering — Posted on 2021-01-27
557 Evaluation of solubility and histological effect of 11-keto-β-Boswellic acid on the diabetic mice liver using FTIR-PCA analysis and microscopy
Al-Amri, I.; Mabood, F.; Kadim, I. T.; Alkindi, A.; Al-Harrasi, A.; Al-Hashmi, S.; Abbas, G.; Ahmed, B.; Al-Shuhaimi, J.; Khalaf, S.; Shaikh, J.
10.1101/2021.01.27.428445 — developmental biology — Posted on 2021-01-27
561 Maternal transfer of neutralizing antibodies to OspA after oral vaccination of the rodent reservoir
O'Connell, K.; Nair, N.; Samanta, K.; Azevedo, J. F.; Brown, G. D.; Petersen, C. A.; Gomes-Solecki, M.
10.1101/2021.01.27.428441 — microbiology — Posted on 2021-01-27
563 A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response
Connolly, K. A.; Kuchroo, M.; Venkat, A.; Khatun, A.; Wang, J.; William, I.; Hornick, N.; Fitzgerald, B.; Damo, M.; Kasmani, M. Y.; Cui, C.; Fagerberg, E.; Monroy, I.; Hutchins, A.; Cheung, J. F.; Foster, G. G.; Mariuzza, D. L.; Zhao, H.; Cui, W.; Krishnaswamy, S.; Joshi, N. S.
10.1101/2021.01.27.428467 — immunology — Posted on 2021-01-27
565 Iron-loading is a prominent feature of activated microglia in Alzheimer's disease patients
Kenkhuis, B.; Somarakis, A.; de Haan, L. M.; Dzyubachyk, O.; IJsselsteijn, M. E.; de Miranda, N. F.; Lelieveldt, B. P.; Dijkstra, J.; van Roon-Mom, W. M.; Hollt, T.; van der Weerd, L.
10.1101/2021.01.27.428379 — neuroscience — Posted on 2021-01-27
567 Abolished miR158 activity leads to 21-nucleotide tertiary phasiRNA biogenesis that targets NHX2 in Arabidopsis thaliana
Tripathi, A. M.; Singh, R.; Singh, A.; Verma, A. K.; Mishra, P.; Narayan, S.; Shirke, P. A.; Roy, S.
10.1101/2021.01.27.428373 — plant biology — Posted on 2021-01-27
569 Historical trade routes for diversification of domesticated chickpea inferred from landrace genomics
Igolkina, A. A.; Noujdina, N. V.; Samsonova, M. G.; von Wettberg, E.; Longcore, T.; Nuzhdin, S.
10.1101/2021.01.27.428389 — plant biology — Posted on 2021-01-27
570 Aureochromes are necessary for maintaining polyunsaturated fatty acid content in Nannochloropsis oceanica
Farre, E. M.; Poliner, E.; Busch, A. W.; Newton, L.; Kim, Y. U.; Clark, R.; Gonzalez-Martinez, S. C.; Jeong, B.-r.; Montgomery, B. L.
10.1101/2021.01.27.428447 — plant biology — Posted on 2021-01-27
576 A U-Net model of local brain-age
Popescu, S. G.; Glocker, B.; Sharp, D. J.; Cole, J. H.
10.1101/2021.01.26.428243 — neuroscience — Posted on 2021-01-27
579 Causal emergence of task information from dynamic network interactions in the human brain
Mill, R. D.; Hamilton, J. L.; Winfield, E. C.; Lalta, N.; Chen, R. H.; Cole, M. W.
10.1101/2021.01.26.428276 — neuroscience — Posted on 2021-01-27
581 Segmentor: A tool for manual refinement of 3D microscopy annotations
Borland, D.; McCormick, C. M.; Patel, N. K.; Krupa, O.; Mory, J. T.; Beltran, A. A.; Farah, T. M.; Escobar-Tomlienovich, C. F.; Olson, S. S.; Kim, M.; Wu, G.; Stein, J. L.
10.1101/2021.01.25.428119 — neuroscience — Posted on 2021-01-27
582 BNP facilitates NMB-mediated histaminergic itch via NPRC-NMBR crosstalk
Meng, Q.-T.; Liu, X.-Y.; Liu, X.-T.; Barry, D. M.; Jin, H.; Sun, Y.; Yang, Q.; Wan, L.; Jin, J.-H.; Shen, K.-F.; Munanairi, A.; Kim, R.; Yin, J.; Tao, A.; Chen, Z.
10.1101/2021.01.26.428310 — neuroscience — Posted on 2021-01-27
583 SpatialExperiment: infrastructure for spatially resolved transcriptomics data in R using Bioconductor
Righelli, D.; Weber, L. M.; Crowell, H. L.; Pardo, B.; Collado-Torres, L.; Ghazanfar, S.; Lun, A. T.; Hicks, S. C.; Risso, D.
10.1101/2021.01.27.428431 — bioinformatics — Posted on 2021-01-27
585 Natural diversity of honey bee (Apis mellifera) gut bacteriome in various climatic and seasonal states
Papp, M.; Békési, L.; Farkas, R.; Makrai, L.; Maróti, G.; Tözsér, D.; Solymosi, N.
10.1101/2021.01.27.428438 — genomics — Posted on 2021-01-27
588 Early life experience sets hard limits on motor learning as evidenced from artificial arm use
Maimon-Mor, R. O.; Schone, H. R.; Henderson Slater, D.; Faisal, A. A.; Makin, T. R.
10.1101/2021.01.26.428281 — neuroscience — Posted on 2021-01-27
589 Influence of visual feedback persistence on visuo-motor skill improvement
Unell, A.; Eisenstat, Z. M.; Braun, A.; Gandhi, A.; Gilad-Gutnick, S.; Ben-Ami, S.; Sinha, P.
10.1101/2021.01.26.428288 — neuroscience — Posted on 2021-01-27
590 Resting State Functional Connectivity Predicts Future Changes in Sedentary Behavior
Morris, T. P.; Kucyi, A.; Arnold Anteraper, S.; Geddes, M. R.; Nieto-Castanon, A.; Burzynska, A.; Gothe, N.; Fanning, J.; Salerno, E.; Whitfield-Gabrieli, S.; Hillman, C. H.; McAuley, E.; Kramer, A. F.
10.1101/2021.01.26.428161 — neuroscience — Posted on 2021-01-27
593 Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release
Ijäs, H.; Shen, B.; Heuer-Jungemann, A.; Keller, A.; Kostiainen, M. A.; Liedl, T.; Ihalainen, J. A.; Linko, V.
10.1101/2020.05.13.088054 — biochemistry — Posted on 2021-01-27
594 Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells
Peron, M.; Meneghetti, G.; Dinarello, A.; Martorano, L.; Betto, R. M.; Facchinello, N.; Tesoriere, A.; Tiso, N.; Martello, G.; Argenton, F.
10.1101/2020.07.17.208264 — developmental biology — Posted on 2021-01-27
600 An Updated Investigation Prior To COVID-19 Vaccination Program In Indonesia: Full-Length Genome Mutation Analysis Of SARS-CoV-2
Nidom, R. V.; Indrasari, S.; Normalina, I.; Nidom, A. N.; Afifah, B.; Dewi, L.; Putra, A. K.; Ansori, A. N. M.; Kusala, M. K. J.; Alamudi, M. Y.; Nidom, C. A.
10.1101/2021.01.26.426655 — molecular biology — Posted on 2021-01-27
601 Neutralization of spike 69/70 deletion, E484K, and N501Y SARS-CoV-2 by BNT162b2 vaccine-elicited sera
Xie, X.; Liu, Y.; Liu, J.; Zhang, X.; Zou, J.; Fontes-Garfias, C. R.; Xia, H.; Swanson, K. A.; Cutler, M.; Cooper, D.; Menachery, V. D.; Weaver, S.; Dormitzer, P.; Shi, P.-Y.
10.1101/2021.01.27.427998 — microbiology — Posted on 2021-01-27
602 Sequence signatures of two IGHV3-53/3-66 public clonotypes to SARS-CoV-2 receptor binding domain
Tan, T. J. C.; Yuan, M.; Kuzelka, K.; Padron, G. C.; Beal, J. R.; Chen, X.; Wang, Y.; Rivera-Cardona, J.; Zhu, X.; Stadtmueller, B. M.; Brooke, C. B.; Wilson, I. A.; Wu, N. C.
10.1101/2021.01.26.428356 — microbiology — Posted on 2021-01-27
603 Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model
Caceres, C. J.; Cardenas-Garcia, S.; Carnaccini, S.; Seibert, B.; Rajao, D. S.; Wang, J.; Perez, D. R.
10.1101/2021.01.27.428428 — microbiology — Posted on 2021-01-27
604 Low-Dose Ad26.COV2.S Protection Against SARS-CoV-2 Challenge in Rhesus Macaques
He, X.; Chandrashekar, A.; Zahn, R. C.; Wegmann, F.; Yu, J.; Mercado, N. B.; McMahan, K.; Martinot, A. J.; Piedra-Mora, C.; Beecy, S.; Ducat, S.; Chamanza, R.; Rosendahl Huber, S.; van der Fits, L.; Borducchi, E. N.; Lifton, M.; Liu, J.; Nampanya, F.; Patel, S.; Peter, L.; Tostanoski, L. H.; Pessaint, L.; Van Ry, A.; Finneyfrock, B.; Velasco, J.; Teow, E.; Brown, R.; Cook, A.; Andersen, H.; Lewis, M. G.; Schuitemaker, H.; Barouch, D. H.
10.1101/2021.01.27.428380 — immunology — Posted on 2021-01-27
606 Neutralization of UK-variant VUI-202012/01 with COVAXIN vaccinated human serum
Sapkal, G. N.; Yadav, P.; Ella, R.; Deshpande, G.; Sahay, R.; Gupta, N.; Mohan, V. K.; Abraham, P.; Panda, S.; Bhargava, B.
10.1101/2021.01.26.426986 — microbiology — Posted on 2021-01-27
608 Enhanced laterally resolved ToF-SIMS and AFM imaging of the electrically conductive structures in cable bacteria
Thiruvallur Eachambadi, R.; Boschker, H. T. S.; Franquet, A.; Spampinato, V.; Hidalgo-Martinez, S.; Valcke, R.; Meysman, F. J. R.; Manca, J. V.
10.1101/2021.01.27.428206 — cell biology — Posted on 2021-01-27
609 Spatiotemporal organization of BamA governs the pattern of outer membrane protein distribution in growing Escherichia coli cells
Mamou, G.; Inns, P. G.; Sun, D.; Kaminska, R.; Housden, N. G.; Cohen Khait, R.; Miller, H.; Storek, K. M.; Rutherford, S. T.; Payandeh, J.; Kleanthous, C.
10.1101/2021.01.27.428258 — microbiology — Posted on 2021-01-27
611 Fitness cost of vancomycin-resistant Enterococcus faecium plasmids associated with hospital infection outbreaks
Tedim, A. P.; Lanza, V. F.; Rodriguez, C. M.; Freitas, A. R.; Novais, C.; Peixe, L.; Baquero, F.; COQUE, T. M.
10.1101/2021.01.27.428397 — microbiology — Posted on 2021-01-27
612 Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress
Liang, J.; Ruthel, G.; Sagum, C.; Bedford, M. T.; Sidhu, S.; Sudol, M.; Jaladanki, C. K.; Fan, H.; Freedman, B.; Harty, R. N.
10.1101/2021.01.26.428359 — microbiology — Posted on 2021-01-27
615 Application of the SMALP technology to the isolation of GPCRs from low-yielding cell lines
Tedesco, D.; Maj, M.; Malarczyk, P.; Cingolani, A.; Zaffagnini, M.; Wnorowski, A.; Benelli, T.; Mazzoni, R.; Bartolini, M.; Jozwiak, K.
10.1101/2021.01.26.428305 — biophysics — Posted on 2021-01-27
617 Linear-Nonlinear Cascades Capture Synaptic Dynamics
Rossbroich, J.; Trotter, D.; Beninger, J.; Toth, K.; Naud, R.
10.1101/2020.06.04.133892 — neuroscience — Posted on 2021-01-27
618 Structural basis for Potassium transport by KdpFABC
Sweet, M. E.; Larsen, C.; Zhang, X.; Schlame, M.; Pedersen, B. P.; Stokes, D. L.
10.1101/2021.01.09.426067 — biophysics — Posted on 2021-01-27
622 Tyrosinase from mushroom Agaricus bisporus as an inhibitor of the Hepatitis C virus
Lopez-Tejedor, D.; Claveria-Gimeno, R.; Velazquez-Campoy, A.; Abian, O.; Palomo, J. M.
10.1101/2020.12.23.424187 — microbiology — Posted on 2021-01-27
624 The Effect of Task on Object Processing revealed by EEG decoding
Yip, H. M. K.; Cheung, L. Y. T.; Ngan, V. S. H.; Wong, Y. K.; Wong, A. C.- N.
10.1101/2020.08.18.255018 — neuroscience — Posted on 2021-01-27
626 Spatial analysis of ligand-receptor interaction in skin cancer at genome-wide and single-cell resolution
Tran, M.; Yoon, S.; Siok, M. T.; Andersen, S.; Lam, P.; Purdue, B.; Raghubar, A.; Hanson, S. J.; Devitt, K.; Jones, K.; Walters, S.; Tuong, Z. K.; Kulasinghe, A.; Monkman, J.; Soyer, P. H.; Frazer, I. H.; Nguyen, Q.
10.1101/2020.09.10.290833 — cancer biology — Posted on 2021-01-27
629 Organization of DNA replication origin firing in Xenopus egg extracts : the role of intra-S checkpoint
Ciardo, D.; Haccard, O.; Narassimprakash, H.; Arbona, J.-M.; Hyrien, O.; Audit, B.; Marheineke, K.; Goldar, A.
10.1101/2020.06.22.164673 — cell biology — Posted on 2021-01-27
632 Predicting MEG resting-state functional connectivity using microstructural information
Messaritaki, E.; Foley, S.; Schiavi, S.; Magazzini, L.; Routley, B.; Jones, D. K.; Singh, K. D.
10.1101/2020.09.15.298307 — neuroscience — Posted on 2021-01-27
633 A miR-124-mediated post-transcriptional mechanism controlling the cell fate switch of astrocytes to induced-neurons
Papadimitriou, E.; Koutsoudaki, P. N.; Karamitros, T.; Karagkouni, D.; Chroni-Tzartou, D.; Margariti, M.; Gkemisis, C.; Xingi, E.; Thanou, I.; Tzartos, S. J.; Hatzigeorgiou, A. G.; Thomaidou, D.
10.1101/2020.06.01.127126 — neuroscience — Posted on 2021-01-27
635 A Connectivity-based Psychometric Prediction Framework for Brain-behavior Relationship Studies
Wu, J.; Eickhoff, S. B.; Hoffstaedter, F.; Patil, K. R.; Schwender, H.; Yeo, B. T. T.; Genon, S.
10.1101/2020.01.15.907642 — neuroscience — Posted on 2021-01-27
638 First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays
Gao, F.; Yang, Y.; Zhu, H.; Wang, J.; Xiao, D.; Zhou, Z.; Dai, T.; Zhang, Y.; Feng, G.; Li, J.; Lin, B.; Xie, G.; Ke, Q.; Li, P.; Sheng, X.; Wang, H.; Yan, L.; Lao, C.; Li, M.; Lu, Y.; Zhao, J.; Feng, S.; Wu, D.; Du, X.
10.1101/2020.11.27.401869 — cancer biology — Posted on 2021-01-27
641 Paths to annihilation: Genetic and demographic consequences of range contraction patterns
Rogan, J.; Parker, M. R.; Hancock, Z. B.; Earl, A. D.; Buchholtz, E. K.; Chyn, K.; Martina, J.; Fitzgerald, L. A.
10.1101/2021.01.26.428313 — ecology — Posted on 2021-01-27
644 Identification of TIA1 mRNA targets during human neuronal development
Byres, L. P.; Mufteev, M.; Yuki, K. E.; Wei, W.; Piekna, A.; Wilson, M. D.; Rodrigues, D. C.; Ellis, J.
10.1101/2021.01.26.428265 — neuroscience — Posted on 2021-01-27
646 Microenvironment Impacts the Molecular Architecture and Interactivity of Resident Cells in Marmoset Brain
Lin, J.-P.; Kelly, H. M.; Song, Y.; Kawaguchi, R.; Geschwind, D.; Jacobson, S.; Reich, D. S.
10.1101/2021.01.25.426385 — neuroscience — Posted on 2021-01-27
647 Probability-based mechanisms in biological networks with parameter uncertainty
Ortega, O. O.; Wilson, B. A.; Pino, J. C.; Irvin, M. W.; Ildefonso, G. V.; Garbett, S. P.; Lopez, C. F.
10.1101/2021.01.26.428266 — systems biology — Posted on 2021-01-27
649 Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain
Bialas, A.; Langner, T.; Harant, A.; Contreras, M. P.; Stevenson, C. E. M.; Lawson, D. M.; Sklenar, J.; Kellner, R.; Moscou, M. J.; Terauchi, R.; Banfield, M. J.; Kamoun, S.
10.1101/2021.01.26.428286 — plant biology — Posted on 2021-01-27
650 tTARGIT AAVs: A sensitive and flexible method to manipulate intersectional neuronal populations
Sabatini, P.; Wang, J.; Rupp, A. C.; Affinati, A. H.; Flak, J. N.; Li, C.; Olson, D.; Myers, M.
10.1101/2021.01.26.428259 — physiology — Posted on 2021-01-27
651 Selective uptake into inflamed human intestinal tissue and immune cell targeting by wormlike polymer micelles
Gardey, E.; Sobotta, F. H.; Haziri, D.; Grunert, P. C.; Kuchenbrod, M. T.; Gruschwitz, F. V.; Hoeppener, S.; Schumann, M.; Gassler, N.; Stallmach, A.; Brendel, J. C.
10.1101/2021.01.26.428316 — physiology — Posted on 2021-01-27
652 Niclosamide Inhalation Powder Made by Thin-Film Freezing: Pharmacokinetic and Toxicology Studies in Rats and Hamsters
Jara, M. O.; Warnken, Z. N.; Sahakijpijarn, S.; Moon, C.; Maier, E. Y.; Christensen, D. J.; Koleng, J. J.; Peters, J. I.; Hackman, S. D.; Williams, R. O.
10.1101/2021.01.26.428293 — pharmacology and toxicology — Posted on 2021-01-27
656 Normalization benchmark of ATAC-seq datasets shows the importance of accounting for GC-content effects
Van den Berge, K.; Chou, H.-J.; Roux de Bezieux, H.; Street, K.; Risso, D.; Ngai, J.; Dudoit, S.
10.1101/2021.01.26.428252 — bioinformatics — Posted on 2021-01-27
657 Towards Similarity-based Differential Diagnostics For Common Diseases
Slater, L. T.; Karwath, A.; Williams, J. A.; Russell, S.; Makepeace, S.; Carberry, A.; Hoehndorf, R.; Gkoutos, G. V.
10.1101/2021.01.26.428269 — bioinformatics — Posted on 2021-01-27
659 Taurine suppresses liquid-liquid phase separation of lysozyme protein
Tsubotani, K.; Maeyama, S.; Murakami, S.; Schaffer, S. W.; Ito, T.
10.1101/2021.01.26.428332 — biochemistry — Posted on 2021-01-27
662 Training with an auditory perceptual learning game transfers to speech in competition
Lelo de Larrea-Mancera, E. S.; Phillipp, M. A.; Stavropoulos, T.; Carrillo, A. A.; Cheong, S.; Koerner, T.; Molis, M. R.; Gallun, F. J.; Seitz, A. R.
10.1101/2021.01.26.428343 — animal behavior and cognition — Posted on 2021-01-27
663 Maternal lineages from 10-11th century commoner cemeteries of the Carpathian Basin
Maar, K.; Varga, G. I. B.; Kovacs, B.; Schutz, O.; Maroti, Z.; Kalmar, T.; Nyerki, E.; Nagy, I.; Latinovics, D.; Tihanyi, B.; Marcsik, A.; Palfi, G.; Bernert, Z.; Gallina, Z.; Varga, S.; Kolto, L.; Rasko, I.; Torok, T.; Neparaczki, E.
10.1101/2021.01.26.428268 — genetics — Posted on 2021-01-27
668 Deep Directed Evolution of Solid Binding Peptides for Quantitative Big-Data Generation
Yucesoy, D. T.; Rath, S. S.; Rodriguez, J. L.; Francis-Landau, J. T.; Nakano-Baker, O.; Sarikaya, M.
10.1101/2021.01.26.428348 — molecular biology — Posted on 2021-01-27
669 The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
Hendriks, I. A.; Buch-Larsen, S. C.; Prokhorova, E.; Rebak, A. K. L. F. S.; Ahel, I.; Nielsen, M. L.
10.1101/2021.01.26.428255 — molecular biology — Posted on 2021-01-27
670 Deep-sea plastisphere: long-term colonization by plastic-associated bacterial and archaeal communities in the Southwest Atlantic Ocean
Agostini, L.; Moreira, J. C. F.; Bendia, A. G.; Kmit, M. C. P.; Waters, L. G.; Santana, M. F. M.; Sumida, P. Y. G.; Turra, A.; Pellizari, V. H.
10.1101/2021.01.26.428295 — microbiology — Posted on 2021-01-27
671 Dermal macrophages set pain sensitivity by modulating tissue NGF levels through SNX25-Nrf2 signaling
Tanaka, T.; Okuda, H.; Terada, Y.; Shinjo, T.; Banja, M.; Nishimura, K.; Isonishi, A.; Furue, H.; Takemura, S.; Tatsumi, K.; Wanaka, A.
10.1101/2021.01.26.428327 — immunology — Posted on 2021-01-27
672 TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor
Ferrara, S. J.; Chaudhary, P.; DeBell, M. J.; Marracci, G.; Miller, H.; Calkins, E.; Pocius, E.; Napier, B. A.; Emery, B.; Bourdette, D.; Scanlan, T. S.
10.1101/2021.01.25.428149 — immunology — Posted on 2021-01-27
673 A Developmental Role for Microglial Presenilin 1 in Memory
Ledo, J. H.; Azevedo, E.; Medrihan, L.; Cheng, J.; Silva, H. M.; McCabe, K.; Bamkole, M.; Lafaille, J. J.; Friedman, J. M.; Stevens, B.; Greengard, P.
10.1101/2021.01.26.428181 — neuroscience — Posted on 2021-01-27
674 AI-driven Deep Visual Proteomics defines cell identity and heterogeneity
Mund, A.; Coscia, F.; Hollandi, R.; Kovacs, F.; Kriston, A.; Brunner, A.-D.; Bzorek, M.; Naimy, S.; Rahbek Gjerdrum, L. M.; Dyring-Andersen, B.; Bulkescher, J. M.; Lukas, C.; Gnann, C.; Lundberg, E.; Horvath, P.; Mann, M.
10.1101/2021.01.25.427969 — systems biology — Posted on 2021-01-27
675 L-WNK1 is required for BK channel activation in intercalated cells
Ray, E. C.; Carrisoza, R.; Al-Bataineh, M.; Marciszyn, A. L.; Nkashama, L.; Chen, J. C.; Winfrey, A.; Flores, D.; Wu, P.; Wang, W. C.; wang, c.-l.; Subramanya, A. R.; Kleyman, T. R.; Satlin, L. M.
10.1101/2021.01.26.428162 — physiology — Posted on 2021-01-27
676 Water and Electrolyte Homeostasis in a Mouse Model with Reduced ENaC Gamma Subunit Expression
Ray, E. C.; Jordahl, A.; Marciszyn, A. L.; Winfrey, A.; Lam, T.; Barak, Y.; Sheng, S.; Kleyman, T. R.
10.1101/2021.01.26.428168 — physiology — Posted on 2021-01-27
679 Molecular mechanism of a parasite kinesin motor and implications for its inhibition
Cook, A. D.; Roberts, A.; Atherton, J.; Tewari, R.; Topf, M.; Moores, C. A.
10.1101/2021.01.26.428220 — biophysics — Posted on 2021-01-27
680 Separate neural dynamics underlying the acquisition of different auditory category structures
Feng, G.; Gan, Z.; Yi, H. G.; Ell, S.; Roark, C. L.; Wang, S.; Wong, P. C. M.; Chandresekaran, B.
10.1101/2021.01.25.428107 — bioinformatics — Posted on 2021-01-27
681 Metagenomic evidence for co-occurrence of antibiotic, biocide and metal resistancegenes in pigs
Li, X.; Rensing, C.; Vestergaard, G.; Nesme, J.; Gupta, S.; Arumugamd, M.; Brejnrod, A. D.; sorensen, s.
10.1101/2021.01.26.428250 — bioinformatics — Posted on 2021-01-27
691 Somatic mutations reveal widespread mosaicism and mutagenesis in human placentas
Coorens, T.; Oliver, T.; Sanghvi, R.; Sovio, U.; Cook, E.; Vento-Tormo, R.; Haniffa, M.; Young, M. D.; Rahbari, R.; Sebire, N.; Campbell, P.; Charnock-Jones, D. S.; Smith, G.; Behjati, S.
10.1101/2021.01.26.428217 — genomics — Posted on 2021-01-27
693 Note: Updating the metadata of four misidentified samples in the DrosRTEC dataset
Nunez, J. C. B.; Paris, M.; Machado, H.; Bogaerts, M.; Gonzalez, J.; Flatt, T.; Coronado, M.; Kapun, M.; Schmidt, P.; Petrov, D.; Bergland, A.
10.1101/2021.01.26.428249 — genomics — Posted on 2021-01-27
697 Correlated Evolution in the Small Parsimony Framework
Smith, B.; Buonopane, R.; Navarro-Martinez, C.; Byun, A. S.; Patterson, M. D.
10.1101/2021.01.26.428213 — evolutionary biology — Posted on 2021-01-27
701 A hierarchical Bayesian model to investigate trade-offs between growth and reproduction in a long-lived plant
Journe, V.; Papaix, J.; Walker, E.; Courbet, F.; Lefevre, F.; Oddou-Muratorio, S.; Davi, H.
10.1101/2021.01.26.428205 — ecology — Posted on 2021-01-27
704 Does where you live influence what you are made of? Spatial correlates of chemical traits across commonly occurring boreal plants
Heckford, T. R.; Leroux, S. J.; Vander Wal, E.; Rizzuto, M.; Balluffi-Fry, J.; Richmond, I. C.; Wiersma, Y. F.
10.1101/2021.01.26.428320 — ecology — Posted on 2021-01-27
706 Expression and Manufacturing of Protein Therapeutics in Spirulina
Jester, B.; Zhao, H.; Gewe, M.; Adame, T.; Perruzza, L.; Bolick, D.; Agosti, J.; Khuong, N.; Kuestner, R.; Gamble, C.; Cruickshank, K.; Ferrara, J.; Lim, R.; Paddock, T.; Brady, C.; Ertel, S.; Zhang, M.; Tasch, M.; Saveria, T.; Doughty, D.; Marshall, J.; Carrieri, D.; Lee, J.; Goetsch, L.; Dang, J.; Sanjaya, N.; Fletcher, D.; Martinez, A.; Kadis, B.; Sigmar, K.; Afreen, E.; Nguyen, T.; Randolph, A.; Taber, A.; Krzeszowski, A.; Robinett, B.; Grassi, F.; Guerrant, R.; Spigarelli, M.; Takeuchi, R.; Finrow, B.; Behnke, C.; Roberts, J.
10.1101/2021.01.25.427910 — molecular biology — Posted on 2021-01-27
713 Training Data: How can we best prepare instructors to teach data science in undergraduate biology and environmental science courses?
Emery, N. C.; Crispo, E.; Supp, S. R.; Kerkhoff, A. J.; Farrell, K. J.; Bledsoe, E. K.; O'Donnell, K. L.; McCall, A. C.; Aeillo-Lammens, M.
10.1101/2021.01.25.428169 — scientific communication and education — Posted on 2021-01-27
718 Inhalable textile microplastic fibers impair airway epithelial growth
van Dijk, F.; Song, S. S.; van Eck, G.; Wu, X. H.; Bos, S.; Boom, D.; Kooter, I.; Spierings, D. C. J. N.; Wardenaar, R.; Cole, M.; Salvati, A.; Gosens, R.; Melgert, B. N.
10.1101/2021.01.25.428144 — pharmacology and toxicology — Posted on 2021-01-27
720 Youthful and age-related matreotypes predict drugs promoting longevity
Statzer, C.; Jongsma, E.; Liu, S. X.; Dakhovnik, A.; Wandrey, F.; Mozharovskyi, P.; Zuelli, F.; Ewald, C. Y.
10.1101/2021.01.26.428242 — pharmacology and toxicology — Posted on 2021-01-27
724 LanceOtron: a deep learning peak caller for ATAC-seq, ChIP-seq, and DNase-seq
Hentges, L. D.; Sergeant, M. D.; Downes, D. J.; Hughes, J. R.; Taylor, S.
10.1101/2021.01.25.428108 — bioinformatics — Posted on 2021-01-27
725 Can we put Humpty Dumpty back together again? What does protein quantification mean in bottom-up proteomics?
Plubell, D. L.; Käll, L.; Webb-Robertson, B.-J.; Bramer, L.; Ives, A.; Kelleher, N. L.; Smith, L. M.; Montine, T. J.; Wu, C. C.; MacCoss, M. J.
10.1101/2021.01.25.428175 — biochemistry — Posted on 2021-01-27
726 The urea cycle is transcriptionally controlled by hypoxia-inducible factors
Singh, C.; Benos, A.; Grenell, A.; Tran, V.; Hanna, D.; Kannekanti, N.; Anand-Apte, B.; Brunengraber, H.; Sears, J.
10.1101/2021.01.25.428152 — biochemistry — Posted on 2021-01-27
728 Endometrial Gap Junction Expression - Early Indicators of Endometriosis and Integral to Invasiveness
Nicholson, B.; Kirma, N. B.; Chen, C.-W.; Chavez, J. B.; Lin, L.-L.; Wang, C.-M.; Hsu, Y.-T.; Hart, M. J.; Ruan, J.; Gillette, L. H.; Burney, R. O.; Schenken, R. S.; Robinson, R. D.; Osmulski, P.; Gaczynska, M.
10.1101/2021.01.25.428135 — cell biology — Posted on 2021-01-26
729 Baseline cell proliferation rates and response to UV differ in Lymphoblastoid Cell Lines derived from healthy individuals of extreme constitution types
Chakraborty, S.; Singhmar, S.; Singh, D.; Maulik, M.; Patil, R.; Agrawal, S. K.; Mishra, A.; Ghazi, M.; Vats, A.; Natarajan, v. T.; Juvekar, S.; Prasher, B.; Mukerji, M.
10.1101/2021.01.26.428133 — cell biology — Posted on 2021-01-26
730 Fibroblast State Reversal By MBNL1-Dependent Transcriptome Modification Regulates Cardiac Repair
Bugg, D.; Bretherton, R.; Beach, K.; Reese, A.; Gunaje, J.; Flint, G.; DeForest, C. A.; Stempien-Otero, A.; Davis, J.
10.1101/2021.01.26.428279 — cell biology — Posted on 2021-01-26
731 Human stem cell model of HNF1A deficiency shows uncoupled insulin to C-peptide secretion with accumulation of abnormal insulin granules
Gonzalez, B. J.; Zhao, H.; Niu, J.; Williams, D. J.; Lee, J.; Goulbourne, C. N.; Xing, Y.; Wang, Y.; Oberholzer, J.; Chen, X.; LeDuc, C. A.; Chung, W. K.; Colecraft, H. M.; Gromada, J.; Shen, Y.; Goland, R. S.; Leibel, R. L.; Egli, D.
10.1101/2021.01.26.428260 — cell biology — Posted on 2021-01-26
733 Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells
Bowler-Barnett, E.; Martinez-Garcia, F.; Sherwood, M.; Weston, S.; Wang, Y.; Divecha, N.; Skipp, P.; Ewing, R. M.
10.1101/2021.01.26.428222 — cancer biology — Posted on 2021-01-26
734 Modulation of implanted aortic scaffold- involvement of ECM and immune proteins
Banerjee, D.; Nayakawde, N. B.; Antony, D.; Deshmukh, M.; Ghosh, S.; Sihlbom, C.; Ul Haq, U.; Olausson, M.
10.1101/2020.11.21.392654 — bioengineering — Posted on 2021-01-26
735 Evidence for a role of phenotypic mutations in virus adaptation
Luzon-Hidalgo, R.; Risso, V. A.; Delgado, A.; Andres-Leon, E.; Ibarra-Molero, B.; Sanchez-Ruiz, J. M.
10.1101/2020.08.21.261495 — evolutionary biology — Posted on 2021-01-26
737 Structural and functional studies of the first tripartite protein complex at the Trypanosoma brucei flagellar pocket collar
BONHIVERS, M.; Isch, C.; Majneri, P.; Landrein, N.; Pivovarova, Y.; Lesigang, J.; Lauruol, F.; Robinson, D. R.; Dong, G.
10.1101/2021.01.26.428227 — cell biology — Posted on 2021-01-26
739 Modeling by artificial neural networks of silver carp (Hypophthalmichthys molitrixi) with sous vide processing on the effects of storage and processing temperatures on the microbiological status
Hosseini, S. V.; Pero, M.; Tahergorabi, R.; Kazemzadeh, S.; Santos Aleman, R.; Abrahan Marcia Fuentes, J.; Montero Fernandez, I.; Sosa, L.; Feas Sanchez, X.
10.1101/2021.01.26.428224 — microbiology — Posted on 2021-01-26
743 All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity
Severin, D.; Hong, S. Z.; Roh, S.-E.; Huang, S.; Zhou, J.; Bridi, M. C. D.; Murase, S.; Robertson, S.; Haberman, R.; Huganir, R.; Gallaghe, M.; Quinlan, E. M.; Worley, P.; kirkwood, a.
10.1101/2020.12.30.424871 — neuroscience — Posted on 2021-01-26
744 Imagined speech can be decoded from low- and cross-frequency features in perceptual space
Proix, T.; Delgado Saa, J.; Christen, A.; Martin, S.; Pasley, B. N.; Knight, R. T.; Tian, X.; Poeppel, D.; Doyle, W. K.; Devinsky, O.; Arnal, L. H.; Megevand, P.; Giraud, A.-L.
10.1101/2021.01.26.428315 — neuroscience — Posted on 2021-01-26
747 High-order areas and auditory cortex both represent the high-level event structure of music
Williams, J. A.; Margulis, E. H.; Nastase, S. A.; Chen, J.; Hasson, U.; Norman, K. A.; Baldassano, C. A.
10.1101/2021.01.26.428291 — neuroscience — Posted on 2021-01-26
749 Dual mechanism estrogen receptor inhibitors
Min, J.; Nwachukwu, J. C.; Srinivasan, S.; Rangarajan, E.; Nettles, C. C.; Sanabria Guillen, V.; Ziegler, Y.; Yan, S.; Carlson, K.; Hou, Y.; Kim, S. H.; Novick, S.; Pascal, B.; Houtman, R.; Griffin, P.; Izard, T.; Katzenellenbogen, B.; Katzenellenbogen, J. A.; Nettles, K. W.
10.1101/2020.07.06.189977 — cancer biology — Posted on 2021-01-26
751 Genetic diversity, distribution and domestication history of the neglected GGAtAt genepool of wheat
Badaeva, E. D.; Konovalov, F. A.; Knuepffer, H.; Fricano, A.; Ruban, A. S.; Kehel, Z.; Zoshchuk, S. A.; Surzhikov, S. A.; Neumann, K.; Graner, A.; Hammer, K.; Filatenko, A. A.; Bogaard, A.; Jones, G.; Ozkan, H.; Kilian, B.
10.1101/2021.01.10.426084 — evolutionary biology — Posted on 2021-01-26
752 Local adaptation and archaic introgression shape global diversity at human structural variant loci
Yan, S. M.; Sherman, R. M.; Taylor, D. J.; Nair, D. R.; Bortvin, A. N.; Schatz, M. C.; McCoy, R. C.
10.1101/2021.01.26.428314 — evolutionary biology — Posted on 2021-01-26
756 Streptococcus suis induces expression of cyclooxygenase-2 in porcine lung tissue
Dresen, M.; Schenk, J.; Berhanu Weldearegay, Y.; Vötsch, D.; Baumgärtner, W.; Valentin-Weigand, P.; Nerlich, A.
10.1101/2020.11.10.371575 — microbiology — Posted on 2021-01-26
757 Paradoxical stabilization of relative position in moving frames
Özkan, M.; Anstis, S.; 't Hart, B. M.; Wexler, M.; Cavanagh, P.
10.1101/2021.01.23.427924 — neuroscience — Posted on 2021-01-26
759 A physicochemical model of odor sampling
Gronowitz, M. E.; Liu, A.; Qiu, Q.; Yu, C. R.; Cleland, T. A.
10.1101/2020.06.16.154807 — neuroscience — Posted on 2021-01-26
761 Architecture of the Neuro-Glia-Vascular System
Zisis, E.; Keller, D.; Kanari, L.; Arnaudon, A.; Gevaert, M.; Delemontex, T.; Coste, B.; Foni, A.; Abdellah, M.; Cali, C.; Hess, K.; Magistretti, P. J.; Schürmann, F.; Markram, H.
10.1101/2021.01.19.427241 — neuroscience — Posted on 2021-01-26
762 Replacement of microglia by brain-engrafted macrophages provide protection against concussive injury
Feng, X.; Frias, E.; Paladini, M.-S.; Chen, D.; Boosalis, Z.; Becker, M.; Gupta, S.; Liu, S.; Gupta, N.; Rosi, S.
10.1101/794354 — neuroscience — Posted on 2021-01-26
764 Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction
Arif, M.; Klevstig, M.; Benfeitas, R.; Doran, S.; Turkez, H.; Uhlen, M.; Clausen, M.; Wikström, J.; Etal, D.; Zhang, C.; Levin, M.; Mardinoglu, A.; Boren, J.
10.1101/2020.10.28.358556 — systems biology — Posted on 2021-01-26
768 noisyR: Enhancing biological signal in sequencing datasets by characterising random technical noise
Moutsopoulos, I.; Maischak, L.; Lauzikaite, E.; Vasquez Urbina, S. A.; Williams, E. C.; Drost, H. G.; Mohorianu, I. I.
10.1101/2021.01.17.427026 — bioinformatics — Posted on 2021-01-26
769 Beam image-shift accelerated data acquisition for near-atomic resolution single-particle cryo-electron tomography
Bouvette, J.; Liu, H.-F.; Du, X.; Zhou, Y.; Sikkema, A. P.; Rezende E Mello, J. D. F.; Klemm, B. P.; Huang, R.; Schaaper, R. M.; Borgnia, M. J.; Bartesaghi, A.
10.1101/2020.09.24.294983 — biochemistry — Posted on 2021-01-26
771 Geography is more important than life history in the recent diversification of the tiger salamander complex
Everson, K. M.; Gray, L. N.; Jones, A. G.; Lawrence, N. M.; Foley, M. E.; Sovacool, K. L.; Kratovil, J. D.; Hotaling, S.; Hime, P. M.; Storfer, A.; Parra-Olea, G.; Percino-Daniel, R.; Aguilar-Miguel, X.; O'Neill, E. M.; Zambrano, L.; Shaffer, H. B.; Weisrock, D. W.
10.1101/2020.07.10.197624 — evolutionary biology — Posted on 2021-01-26
786 The dilemma of infection versus colonization at mucosal tissues: immunological and bacteriological features of obstructive tonsillar hypertrophy
Varon, L. S.; De Rosa, J. E.; Rodriguez, R.; Fernandez, P. M.; Billordo, L. A.; Baz, P.; Beccaglia, G.; Spada, N.; Mendoza, T.; Barberis, C.; Vay, C.; Arabolaza, M. E.; Paoli, B.; Arana, E.
10.1101/2021.01.26.428230 — immunology — Posted on 2021-01-26
789 Neuroimmune-glial cells interactions elevate the kynurenine metabolic pathway to sustain neuropathic pain
Maganin, A. G.; Souza, G. R.; Fonseca, M. D.; Lopes, A. H.; Guimaraes, R. M.; Dagostin, A.; Cecilio, N. T.; Mendes, A. S.; Gomes, F. I.; Marques, L. M.; Silva, R. L.; Arruda, L. M.; Santana, D. A.; Lemos, H.; Huang, L.; Davoli-Ferreira, M.; Coelho, D. S.; Santanna, M. B.; Kusuda, R. K.; Talbot, J.; Pacholczyk, G.; Buqui, G. A.; Lopes, N. P.; Alves-Filho, J. C.; Leao, R.; OConnor, J. C.; Cunha, F. Q.; Mellor, A.; Cunha, T. M.
10.1101/2021.01.25.428142 — neuroscience — Posted on 2021-01-26
792 Single-Cell Proteomics Defines the Cellular Heterogeneity of Localized Prostate Cancer
De Vargas Roditi, L.; Jacobs, A.; Rueschoff, J. H.; Bankheac, P.; Chevrier, S.; Jackson, H.; Hermanns, T.; Fankhauser, C.; Poyet, C.; Chun, F.; Tschaebunin, A.; Bodenmiller, B.; Wild, P.
10.1101/2021.01.25.428046 — cancer biology — Posted on 2021-01-26
793 SNAI2-mediated direct repression of BIM protects rhabdomyosarcoma from ionizing radiation
Wang, L.; Hensch, N. R.; Bondra, K.; Sreenivas, P.; Zhao, X. R.; Chen, J.; Baxi, K.; Campos, R. M.; Gryder, B.; Pomella, S.; Rota, R.; Chen, E. Y.; Khan, J.; Houghton, P. J.; Ignatius, M. S.
10.1101/2021.01.25.428112 — cancer biology — Posted on 2021-01-26
794 Hydrodynamic stress and phenotypic plasticity of the zebrafish regenerating fin
Dagenais, P.; Blanchoud, S.; Pury, D.; Pfefferli, C.; Aegerter-Wilmsen, T.; Aegerter, C. M.; Jazwinska, A.
10.1101/2021.01.25.428094 — biophysics — Posted on 2021-01-26
796 Hybrid Clustering of Long and Short-read for Improved Metagenome Assembly
Lu, Y.; Shi, L.; Van Goethem, M. W.; Sevim, V.; Mascagni, M.; Deng, L.; Wang, Z.
10.1101/2021.01.25.428115 — bioinformatics — Posted on 2021-01-26
803 Engineering a niche supporting haematopoietic stem cell development using integrated single cell transcriptomics
Hadland, B.; Varnum-Finney, B.; Dozono, S.; Dignum, T.; Nourigat-McKay, C.; Jackson, D. L.; Itkin, T.; Butler, J. M.; Rafii, S.; Trapnell, C.; Bernstein, I. D.
10.1101/2021.01.25.427999 — developmental biology — Posted on 2021-01-26
804 Large Organellar Changes occur during Mild Heat Shock in Yeast
Keuenhof, K.; Larsson Berglund, L.; Schneider, K. L.; Malmgren Hill, S.; Widlund, P. O.; Nyström, T.; Höög, J. L.
10.1101/2021.01.25.428102 — cell biology — Posted on 2021-01-26
805 Sulfur-fueled chemolithoautotrophs replenish organic carbon inventory in groundwater
Taubert, M.; Heinze, B. M.; Overholt, W. A.; Azemtsop, G.; Houhou, R.; Jehmlich, N.; von Bergen, M.; Roesch, P.; Popp, J.; Kuesel, K.
10.1101/2021.01.26.428071 — microbiology — Posted on 2021-01-26
806 Mechanotaxis directs Pseudomonas aeruginosa twitching motility.
Tala, L.; Kuhn, M.; Inclan, Y.; Patino, R.; Pierrat, X.; Vos, I.; Al-Mayyah, Z.; MacMillan, H.; Negrete, J.; Engel, J. N.; Persat, A.
10.1101/2021.01.26.428277 — microbiology — Posted on 2021-01-26
807 Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques
Crooks, C. M.; Weiler, A. M.; Rybarczyk, S. L.; Bliss, M. I.; Jaeger, A. S.; Murphy, M. E.; Simmons, H. A.; Mejia, A.; Fritsch, M. K.; Hayes, J. M.; Eickhoff, J. C.; Mitzey, A. M.; Razo, E.; Braun, K. M.; Brown, E. A.; Yamamoto, K.; Shepherd, P. M.; Possell, A.; Weaver, K.; Antony, K. M.; Morgan, T. K.; Newman, C. M.; Dudley, D. M.; Schultz-Darken, N.; Peterson, E.; Katzelnick, L. C.; Balmaseda, A.; Harris, E.; OConnor, D. H.; Mohr, E. L.; Golos, T. G.; Friedrich, T. C.; Aliota, M. T.
10.1101/2021.01.25.428184 — microbiology — Posted on 2021-01-26
809 Microbial population dynamics and evolutionary outcomes under extreme energy-limitation
Shoemaker, W. R.; Jones, S. E.; Muscarella, M. E.; Behringer, M. G.; Lehmkuhl, B. K.; Lennon, J. T.
10.1101/2021.01.25.428163 — microbiology — Posted on 2021-01-26
810 40 minutes RT-qPCR Assay for Screening Spike N501Y and HV69-70del Mutations
Korukluoglu, G.; Kolukirik, M.; Bayrakdar, F.; Ozgumus, G. G.; Altas, A. B.; Cosgun, Y.; Ketre Kolukirik, C. Z.
10.1101/2021.01.26.428302 — microbiology — Posted on 2021-01-26
811 Active viral population dynamics in frozen Arctic peat soil revealed with H218O stable isotope probing metagenomics
Trubl, G.; Kimbrel, J.; Liquet-Gonzalez, J.; Nuccio, E. E.; Weber, P. K.; Pett-Ridge, J.; Jansson, J. K.; Waldrop, M.; Blazewicz, S. J.
10.1101/2021.01.25.428156 — microbiology — Posted on 2021-01-26
812 Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2
Vanshylla, K.; Di Cristianziano, V.; Kleipass, F.; Dewald, F.; Schommers, P.; Gieselmann, L.; Gruell, H.; Schlotz, M.; Ercanoglu, M. S.; Stumpf, R.; Mayer, P.; Heger, E.; Johannis, W.; Horn, C.; Suarez, I.; Jung, N.; Salomon, S.; Eberhardt, K.; Faetkenheuer, G.; Pfeifer, N.; Eggeling, R.; Augustin, M.; Lehmann, C.; Klein, F.
10.1101/2021.01.26.428207 — immunology — Posted on 2021-01-26
813 MRI Radiomic Signature of White Matter Hyperintensities Is Associated with Clinical Phenotypes
Bretzner, M.; Bonkhoff, A. K.; Schirmer, M. D.; Hong, S.; Dalca, A.; Donahue, K. L.; Giese, A.-K.; Etherton, M. R.; Rist, P. M.; Nardin, M.; Marinescu, R.; Wang, C.; Regenhardt, R. W.; Benavente, O. R.; Cole, J. W.; Donatti, A.; Griessenauer, C. J.; Heitsch, L.; Holmegaard, L.; Jood, K.; Jimenez Conde, J.; Kittner, S. J.; Lemmens, R.; Levi, C. R.; McArdle, P. F.; McDonough, C. W.; Meshia, J. F.; Phuah, C.-L.; Rolfs, A.; Ropele, S.; Rosand, J.; Roquer, J.; Rundek, T.; Sacco, R. L.; Schmidt, R.; Sharma, P.; Slowik, A.; Sousa, A.; Stanne, T. M.; Strbian, D.; Tatlisumak, T.; Thijs, V.; Vagala, A.;
10.1101/2021.01.24.427986 — neuroscience — Posted on 2021-01-26
816 Computational Investigation of Increased Virulence and Pathogenesis of SARS-CoV-2 Lineage B.1.1.7
Natarajan, M. A.; S. Javali, P.; Jeyaraj Pandian, C.; Akhtar Ali, M.; Srivastava, V.; Jeyaraman, J.
10.1101/2021.01.25.428190 — pathology — Posted on 2021-01-26
817 Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization
Wang, P.; Lihong, L.; Iketani, S.; Luo, Y.; Guo, Y.; Wang, M.; Yu, J.; Zhang, B.; Kwong, P. D.; Graham, B. S.; Mascola, J. R.; Chang, J. Y.; Yin, M. T.; Sobieszczyk, M. E.; Kyratsous, C. A.; Shapiro, L.; Sheng, Z.; Nair, M. S.; Huang, Y.; Ho, D. D.
10.1101/2021.01.25.428137 — immunology — Posted on 2021-01-26
818 Common variants associated with OSMR expression contribute to carotid plaque vulnerability, but not to cardiovascular disease in humans
van Keulen, D.; van Koeverden, I. D.; Boltjes, A.; Princen, H. M. G.; van Gool, A. J.; de Borst, G. J.; Asselbergs, F. W.; Tempel, D.; Pasterkamp, G.; van der Laan, S. W.
10.1101/576793 — genetics — Posted on 2021-01-26
819 Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in Idiopathic Pulmonary Fibrosis
Marchal-Duval, E.; Homps-Legrand, M.; Froidure, A.; Jaillet, M.; Ghanem, M.; Deneuville, L.; Justet, A.; Maurac, A.; Vadel, A.; Fortas, E.; Cazes, A.; Joannes, A.; Giersch, L.; Mal, H.; Mordant, P.; Mounier, C. M.; Schirduan, X.; Korfei, M.; Gunther, A.; Mari, B.; Jaschinski, F.; Crestani, B.; Mailleux, A. A.
10.1101/2021.01.15.425870 — cell biology — Posted on 2021-01-26
820 Myosin-X and talin modulate integrin activity at filopodia tips
Miihkinen, M.; Grönloh, M. L. B.; Vihinen, H.; Jokitalo, E.; Goult, B. T.; Ivaska, J.; Jacquemet, G.
10.1101/2020.05.05.078733 — cell biology — Posted on 2021-01-26
821 Neutralization of UK-variant VUI-202012/01 with COVAXIN vaccinated human serum
Sapkal, G. N.; Yadav, P.; Ella, R.; Deshpande, G.; Sahay, R.; Gupta, N.; Mohan, V. K.; Abraham, P.; Panda, S.; Bhargava, B.
10.1101/2021.01.26.426986 — molecular biology — Posted on 2021-01-26
822 A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques
Hassan, A. O.; Feldmann, F.; Zhao, H.; Curiel, D. T.; Okumura, A.; Tang-Huau, T.-L.; Case, J. B.; Meade-White, K.; Callison, J.; Lovaglio, J.; Hanley, P. W.; Scott, D. P.; Fremont, D. H.; Feldmann, H.; Diamond, M. S.
10.1101/2021.01.26.428251 — microbiology — Posted on 2021-01-26
823 Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization
Wang, P.; Lihong, L.; Iketani, S.; Luo, Y.; Guo, Y.; Wang, M.; Yu, J.; Zhang, B.; Kwong, P. D.; Graham, B. S.; Mascola, J. R.; Chang, J. Y.; Yin, M. T.; Sobieszczyk, M. E.; Kyratsous, C. A.; Shapiro, L.; Sheng, Z.; Nair, M. S.; Huang, Y.; Ho, D. D.
10.1101/2021.01.25.428137 — immunology — Posted on 2021-01-26
824 Erythropoietin directly remodels the clonal composition of murine hematopoietic multipotent progenitor cells
Eisele, A. S.; Cosgrove, J.; Magniez, A.; Tubeuf, E.; Tenreira Bento, S.; Cayrac, F.; Tak, T.; Lyne, A.-M.; Urbanus, J.; Perie, L.
10.1101/2020.04.20.050146 — immunology — Posted on 2021-01-26
825 Functionnectome: a framework to analyse the contribution of brain circuits to fMRI
Nozais, V.; Forkel, S. J.; Foulon, C. J.; Petit, L.; Thiebaut de Schotten, M.
10.1101/2021.01.06.425574 — neuroscience — Posted on 2021-01-26
827 Long-read-sequenced reference genomes of the seven major lineages of enterotoxigenic Escherichia coli (ETEC) circulating in modern time
von Mentzer, A.; Blackwell, G.; Pickard, D.; Boinett, C. J.; Joffre, E.; Page, A. J.; Svennerholm, A.-M.; Dougan, G.; Sjöling, A.
10.1101/2020.07.16.203430 — genomics — Posted on 2021-01-26
829 Discovery of a protein uptake pathway in lysosomes
Fujiwara, Y.; Contu, V. R.; Kabuta, C.; Ogawa, M.; Fujita, H.; Kikuchi, H.; Sakai, R.; Hase, K.; Suzuki, M.; Koyama-Honda, I.; Inoue, M.; Oya, Y.; U. Inoue, Y.; Inoue, T.; Takahashi, R.; Nishino, I.; Wada, K.; Noguchi, S.; Kabuta, T.
10.1101/2020.08.11.245688 — cell biology — Posted on 2021-01-26
831 A novel SARS-CoV-2 related coronavirus in bats from Cambodia
Hul, V.; Delaune, D.; Karlsson, E. A.; Hassanin, A.; Ou Tey, P.; Baidaliuk, A.; Gambaro, F.; Tu, V. T.; Keatts, L.; Mazet, J.; Johnson, C.; Buchy, P.; Dussart, P.; Goldstein, T.; Simon-Loriere, E.; Duong, V.
10.1101/2021.01.26.428212 — microbiology — Posted on 2021-01-26
832 Immunogenic Potential of DNA Vaccine candidate, ZyCoV-D against SARS-CoV-2 in Animal Models
Dey, A.; Rajanathan TM, C.; Chandra, H.; Pericherla, H. P.; Kumar, S.; Choonia, H. S.; Bajpai, M.; Singh, A. K.; Sinha, A.; Saini, G.; Dalal, P.; Vandriwala, S.; Raheem, M. A.; Divate, R. D.; Navlani, N. L.; Sharma, V.; Parikh, A.; Prasath, S.; Rao, S.; Maithal, K.
10.1101/2021.01.26.428240 — immunology — Posted on 2021-01-26
835 Small peptides modulate the immune function of the ion channel-like protein ACD6 in Arabidopsis thaliana
Zhu, W.; Li, L.; Neuhaeuser, B.; Thelen, M.; Wang, M.; Chen, J.; Wei, L.; Venkataramani, K.; Exposito-Alonso, M.; Liu, C.; Keck, J.; Barragan, A. C.; Schwab, R.; Lutz, U.; Ludewig, U.; Weigel, D.
10.1101/2021.01.25.428077 — plant biology — Posted on 2021-01-26
839 LeafGo: Leaf to Genome, a quick workflow to produce high-quality De novo genomes with Third Generation Sequencing technology
Driguez, P.; Bougouffa, S.; Carty, K.; Putra, A.; Jabbari, K.; Reddy, M.; Soppe, R.; Cheung, N.; Fukasawa, Y.; Ermini, L.
10.1101/2021.01.25.428044 — genomics — Posted on 2021-01-26
840 Pre-mRNA processing entropy in a mouse model of trauma
Jentzsch, M. S.; Fredericks, A. M.; Machan, J. T.; Ayala, A.; Monaghan, S. F.
10.1101/2021.01.25.428080 — genomics — Posted on 2021-01-26
843 miR-24:Prdx6 interactions regulate oxidative stress and viability of myogenic progenitors during ageing
Goljanek-Whysall, K.; Arroquia-Soriano, A.; Gostage, J.; Bardell, D.; McCloskey, E.; Bellantuono, I.; Clegg, P. D.; McDonagh, B.
10.1101/2021.01.25.428069 — cell biology — Posted on 2021-01-26
847 Disrupting D2-NMDA receptor heteromerization blocks the rewarding effects of cocaine but preserves natural reward processing
Andry, A.; Estefani, S.-J.; Paula, P.; Sebastian, F. P.; Anna, P.; Veronique, D. S.-P.; Nicolas, H.; Vanesa, O.; Marie-Charlotte, A.; Vincent, K.; Sandrine, B.; Roman, W.; Ying, Z.; Charlene, J.; Alexis-Pierre, B.; Gustavo, T.; Naguib, M.; Jonathan, J.; Jocelyne, C.; Pierre, T.; Jacques, B.; Peter, V.
10.1101/2021.01.25.428078 — neuroscience — Posted on 2021-01-26
850 Teosinte introgression modulates phosphatidylcholine levels and induces early maize flowering time
Rodriguez-Zapata, F.; Barnes, A. C.; Blocher-Juarez, K. A.; Gates, D. J.; Kur, A.; Wang, L.; Jensen, S. E.; Estevez-Palmas, J. M. M.; Janzen, G. M.; Crow, T. M.; Aguilar-Rangel, R.; Demesa-Arevalo, E.; Skopelitis, T.; Perez-Limon, S.; Stutts, W. L.; Thomson, P. M.; Chiu, Y.-C.; Jackson, D.; Fiehn, O.; Runcie, D.; Buckler, E. S.; Ross-Ibarra, J.; Hufford, M.; Sawers, R. J.; Rellan-Alvarez, R.
10.1101/2021.01.25.426574 — plant biology — Posted on 2021-01-26
854 P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis
Wang, G.; Zhu, M.; Peng, R.; Liang, X.; Lan, Z.; Tang, M.; Song, J. H.; Mak, C. S. L.; Park, J.; Zheng, S.-e.; Huang, A.; Ma, X.; Chen, R.; Chang, Q.; Logothetis, C. J.; Lin, S.-H.; Katayama, H.; Hanash, S. M.
10.1101/2021.01.24.428024 — cancer biology — Posted on 2021-01-26
861 Haploflow: Strain-resolved de novo assembly of viral genomes
Fritz, A.; Bremges, A.; Deng, Z.-L.; Lesker, T.-R.; Goetting, J.; Ganzenmueller, T.; Sczyrba, A.; Dilthey, A.; Klawonn, F.; McHardy, A. C.
10.1101/2021.01.25.428049 — bioinformatics — Posted on 2021-01-26
864 Soil causes gut microbiota to flourish and total serum IgE levels to decrease in mice
Zhou, D.; Li, N.; Yang, F.; Zhang, H.; Bai, Z.; Dong, Y.; Li, M.; Zhu, W.; Fei, Z.; Xiao, P.; Xiao, S.; Lu, Z.
10.1101/2021.01.25.428035 — ecology — Posted on 2021-01-26
867 DNA metabarcoding reveals adaptive seasonal variation of individual trophic traits in a critically endangered fish
Villsen, K.; Corse, E.; Meglecz, E.; Archambaud, G.; Vignes, H.; Ereskovsky, A.; Chappaz, R.; Dubut, V.
10.1101/2021.01.25.428043 — ecology — Posted on 2021-01-26
871 Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering A2BAR signaling on intestinal epithelial cells
El-Naccache, d. w.; chen, f.; palma, m.; lemenze, a.; Wu, w.; mishra, p.; eltzshig, h.; robson, s. c.; Di Virgilio, f.; Hasko, G.; gause, w.
10.1101/2021.01.24.428000 — immunology — Posted on 2021-01-26
873 Nigrostriatal Dopamine Signals Sequence-Specific Action-Outcome Prediction Errors
Hollon, N. G.; Williams, E. W.; Howard, C. D.; Li, H.; Traut, T. I.; Jin, X.
10.1101/2021.01.25.428032 — neuroscience — Posted on 2021-01-26
874 BAG3 regulation of Rab35 mediates the ESCRT/endolysosome pathway and tau clearance
Lin, H.; Tang, M.; Ji, C.; Girardi, P.; Cvetojevic, G.; Chen, Y.; Johnson, G. V.
10.1101/2021.01.25.428055 — neuroscience — Posted on 2021-01-26
876 Global analysis of protein arginine methylation
Zhang, F.; Kerbl-Knapp, J.; Rodriguez-Colman, M. J.; Macher, T.; Vujic, N.; Fasching, S.; Jany-Luig, E.; Korbelius, M.; Kuentzel, K. B.; Mack, M.; Akhmetshina, A.; Paar, M.; Rinner, B.; Hoerl, G.; Steyrer, E.; Stelzl, U.; Burgering, B.; Eisenberg, T.; Pertschy, B.; Kratky, D.; Madl, T.
10.1101/2021.01.25.428036 — systems biology — Posted on 2021-01-26
877 6mer Seed Toxicity and Platinum Resistance in Ovarian Cancer
Patel, M.; Wang, Y.; Bartom, E.; Dhir, R.; Nephew, K.; Matei, D.; Murmann, A.; Lengyel, E.; Peter, M. E.
10.1101/2021.01.24.427815 — cancer biology — Posted on 2021-01-26
878 Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs
Kern, D. M.; Sorum, B.; Mali, S. S.; Hoel, C. M.; Sridharan, S.; Remis, J. P.; Toso, D. B.; Kotecha, A.; Bautista, D. M.; Brohawn, S. G.
10.1101/2020.06.17.156554 — biophysics — Posted on 2021-01-26
880 Reproducibility of protein X-ray diffuse scattering and potential utility for modeling atomic displacement parameters
Su, Z.; Dasgupta, M.; Poitevin, F.; Mathews, I. I.; van den Bedem, H.; Wall, M. E.; Yoon, C. H.; Wilson, M. A.
10.1101/2021.01.24.428002 — biophysics — Posted on 2021-01-26
883 Nuclear cholesterol is required for transcriptional repression by BASP1
Loats, A. E.; Carrera, S.; Fleming, A. F.; Roberts, A. R. E.; Sherrard, A.; Toska, E.; Medler, K. F.; Roberts, S. G. E.
10.1101/2021.01.24.427800 — biochemistry — Posted on 2021-01-26
884 Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D
Deng, Y.; Deng, S.; Ho, Y.-H.; Gardner, S. M.; Huang, Z.; Marmorstein, R.; Huang, R.
10.1101/2021.01.24.427995 — biochemistry — Posted on 2021-01-26
885 Distinct Patterns of Emergence of SARS-CoV-2 Spike Variants including N501Y in Clinical Samples in Columbus Ohio
Tu, H.; Avenarius, M. R.; Kubatko, L.; Hunt, M.; Pan, X.; Ru, P.; Garee, J.; Thomas, K.; Mohler, P.; Pancholi, P.; Jones, D.
10.1101/2021.01.12.426407 — genomics — Posted on 2021-01-26
890 Long-term monitoring reveals topographical features and vegetation explain winter habitat use of an Arctic rodent
von Beckerath, X.; Benadi, G.; Gilg, O.; Sittler, B.; Yannic, G.; Klein, A.-M.; Eitzinger, B.
10.1101/2021.01.24.427984 — ecology — Posted on 2021-01-26
892 Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2
Touret, F.; Driouich, J.-S.; Cochin, M.; Petit, P. R.; Gilles, M.; Barthelemy, K.; Moureau, G.; MAHON, F.-X.; Malvy, D.; Solas, C.; de Lamballerie, X.; Nougairede, A.
10.1101/2020.11.17.386904 — microbiology — Posted on 2021-01-26
894 Induction of a colitogenic phenotype in Th1 cells depends on IL-23R signaling
Pawlak, M.; DeTomaso, D.; Meyer zu Horste, G.; Lee, Y.; Nyman, J.; Dionne, D.; Wang, C.; Wallrapp, A.; Burkett, P. R.; Riesenfeld, S. J.; Anderson, A. C.; Regev, A.; Xavier, R. J.; Yosef, N.; Kuchroo, V. K.
10.1101/2021.01.24.426445 — immunology — Posted on 2021-01-26
896 The brain clock portal system: SCN-OVLT
Yao, Y.; Taub, A. B.; LeSauter, J.; Silver, R.
10.1101/2021.01.24.427962 — neuroscience — Posted on 2021-01-26
897 Deconstruction of the retrosplenial granular cortex for social behavior in the mouse model of fragile X syndrome
Shang, H.-F.; Cai, R.; Sun, H.; Sheng, T.; Lian, Y.-N.; Liu, L.; Chen, W.; Gao, L.; Xu, H.; Zhang, C.; Luo, J.-H.; Li, X.; Li, X.-Y.
10.1101/2021.01.24.428008 — neuroscience — Posted on 2021-01-26
898 Large-scale analysis of interindividual variability in single and paired-pulse TMS data: results from the 'Big TMS Data Collaboration'
Corp, D. T.; Bereznicki, H. G. K.; Clark, G. M.; Youssef, G. J.; Fried, P. J.; Jannati, A.; Davies, C. B.; Gomes-Osman, J.; Kirkovski, M.; Albein-Urios, N.; Fitzgerald, P. B.; Koch, G.; Di Lazzaro, V.; Pascual-Leone, A.; Enticott, P. G.; The Big TMS Data Collaboration,
10.1101/2021.01.24.428014 — neuroscience — Posted on 2021-01-26
901 Heterogeneity in PHGDH protein expression potentiates cancer cell dissemination and metastasis
Rossi, M.; Doglioni, G.; Bornes, L.; Broekart, D.; Planque, M.; Fernandez-Garcia, J.; Rinaldi, G.; Van Elsen, J.; Nittner, D.; Jauset, C.; Rizzollo, F.; Riera Domingo, C.; Orth, M.; Dobrolecki, L. E.; Van Brussel, T.; Teoh, S. T.; Aurora, A.; Eelen, G.; Karras, P.; Sotlar, K.; Bartsch, H.; Marine, J.-C.; Carmeliet, P.; Morrison, S. J.; Lewis, M. T.; Hannon, G.; Mazzone, M.; Lambrechts, D.; van Rheenen, J.; Gruenewald, T. G. P.; Lunt, S. Y.; Fendt, S.-M.
10.1101/2021.01.24.427949 — cancer biology — Posted on 2021-01-26
902 Implant- and anesthesia-related factors affecting threshold intensities for vagus nerve stimulation
Ahmed, U.; Chang, Y.-C.; Lopez, M.; Wong, J.; Datta-Chaudhuri, T.; Rieth, L.; Al-Abed, Y.; Zanos, S.
10.1101/2021.01.22.427329 — bioengineering — Posted on 2021-01-26
905 Hox genes regulate asexual reproductive behavior and tissue segmentation in adult animals
Arnold, C.; Migueles-Lozano, A.; Mann, F. G.; Lange, J. J.; Seidel, C.; Sanchez Alvarado, A.
10.1101/2021.01.24.427972 — developmental biology — Posted on 2021-01-26
906 The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation
Revollo, L.; Merrill-Skoloff, G.; De Ceunynck, K.; Dilks, J.; Bordoli, M.; Peters, C.; Noetzli, L.; Ionescu, A.; Rosen, V.; Italiano, J.; Whitman, M.; Flaumenhaft, R.
10.1101/2021.01.24.427281 — cell biology — Posted on 2021-01-26
911 Generalizable prediction of stimulus-independent, task-unrelated thought from functional brain networks
Kucyi, A.; Esterman, M.; Capella, J.; Green, A.; Uchida, M.; Biederman, J.; Gabrieli, J. D. E.; Valera, E. M.; Whitfield-Gabrieli, S.
10.1101/2021.01.25.428126 — neuroscience — Posted on 2021-01-26
914 A Single Cell Atlas of Lung Development
Negretti, N. M.; Plosa, E. J.; Benjamin, J. T.; Schuler, B. A.; Habermann, A. C.; Jetter, C. S.; Taylor, C. J.; Gulleman, P.; Nichols, D.; Matlock, B. K.; Guttentag, S. H.; Blackwell, T. S.; Banovich, N. E.; Kropski, J. A.; Sucre, J. M.
10.1101/2021.01.21.427641 — developmental biology — Posted on 2021-01-25
916 Combining an alarmin HMGN1 peptide with PD-L1 blockade facilitates stem-like CD8+ T cell expansion and results in robust antitumor effects
Chen, C.-Y.; Ueha, S.; Ishiwata, Y.; Shichino, S.; Yokochi, S.; Yang, D.; Oppenheim, J. J.; Ogiwara, H.; Deshimaru, S.; Kanno, Y.; Ogawa, T.; Shibayama, S.; Matsushima, K.
10.1101/2020.12.15.422990 — immunology — Posted on 2021-01-25
917 Adhatoda Vasica ameliorates cellular hypoxia dependent mitochondrial dysfunction in acute and severe asthmatic mice.
Gheware, A. P.; Panda, L.; Khanna, K.; Bhatraju, N. K.; Jain, V.; Sagar, S.; Kumar, M.; Singh, V. P.; Kannan, S.; Subramanian, V.; Mukerji, M.; Agrawal, A.; Prasher, B.
10.1101/2020.04.01.019430 — immunology — Posted on 2021-01-26
918 Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and is partly compensated by repressive histone modification H3K27me3
Li, J.; Pinto-Duarte, A.; Zander, M.; Lai, C.-Y.; Osteen, J.; Fang, L.; Luo, C.; Lucero, J. D.; Gomez-Castanon, R.; Nery, J. R.; Silva-Garcia, I.; Pang, Y.; Sejnowski, T. J.; Powell, S. B.; Ecker, J. R.; Mukamel, E. A.; Behrens, M. M.
10.1101/2019.12.20.883694 — neuroscience — Posted on 2021-01-25
920 VISUAL network analysis reveals the role of BEH3 as a stabilizer in the secondary vascular development in Arabidopsis
Furuya, T.; Saito, M.; Uchimura, H.; Satake, A.; Nosaki, S.; Miyakawa, T.; Shimadzu, S.; Yamori, W.; Tanokura, M.; Fukuda, H.; Kondo, Y.
10.1101/2021.01.19.427273 — plant biology — Posted on 2021-01-25
921 First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays
Gao, F.; Yang, Y.; Zhu, H.; Wang, J.; Xiao, D.; Zhou, Z.; Dai, T.; Zhang, Y.; Feng, G.; Li, J.; Lin, B.; Xie, G.; Ke, Q.; Li, P.; Sheng, X.; Wang, H.; Yan, L.; Lao, C.; Li, M.; Lu, Y.; Zhao, J.; Feng, S.; Wu, D.; Du, X.
10.1101/2020.11.27.401869 — cancer biology — Posted on 2021-01-25
922 Quantitative coupling of cell volume and membrane tension during osmotic shocks
Roffay, C.; Molinard, G.; Kim, K.; Barbarassa, V.; Urbanska, M.; Mercier, V.; Garcia Calvo, J.; Matile, S.; Guck, J.; Lenz, M.; Roux, A.
10.1101/2021.01.22.427801 — biophysics — Posted on 2021-01-25
925 A new method for determining ribosomal DNA copy number shows differences between Saccharomyces cerevisiae populations
Sharma, D.; Hermann-Le Denmat, S.; Matzke, N. J.; Hannan, K.; Hannan, R. D.; O'Sullivan, J. M.; Ganley, A. R. D.
10.1101/2021.01.21.427686 — genomics — Posted on 2021-01-25
926 Ecological habitat partitioning and feeding specialisations of coastal minke whales (Balaenoptera acutorostrata) using a designated MPA in northeast Scotland
Robinson, K. P.; Bamford, C. C. G.; Brown, W. J.; Culloch, R. M.; Dolan, C. J.; Hall, R.; Russell, G.; Sidiropoulos, T.; Spinou, E.; Sim, T. M. C.; Stroud, E.; Williams, G.; Haskins, G. N.
10.1101/2021.01.25.428066 — ecology — Posted on 2021-01-25
930 NOMIS: Quantifying morphometric deviation from normality over the lifetime in the adult human brain
Potvin, O.; Dieumegarde, L.; Duchesne, S.; Alzheimer's Disease Neuroimaging Initiative and CIMA-Q,
10.1101/2021.01.25.428063 — neuroscience — Posted on 2021-01-25
931 Deciphering the transcriptomic regulation of heat stress responses in Nothofagus pumilio
Estravis-Barcala, M.; Heer, K.; Marchelli, P.; Ziegenhagen, B.; Arana, M. V.; Bellora, N.
10.1101/2021.01.25.428064 — plant biology — Posted on 2021-01-25
938 Ageing and MPTP-sensitivity depend on molecular and ultrastructural signatures of astroglia and microglia in mice nigra
Abhilash, P.; Bharti, U.; Haorei, Y.; Rashmi, S.; Raju, T. R.; Kutty, B. M.; Chandrashekar Sagar, B.; Alladi, P. A.
10.1101/2020.12.15.422212 — neuroscience — Posted on 2021-01-25
940 Intelligence and academic performance: Is it all in your head?
Bottenhorn, K. L.; Bartley, J. E.; Riedel, M. C.; Salo, T.; Bravo, E. I.; Odean, R.; Nazareth, A.; Laird, R. W.; Musser, E. D.; Pruden, S. M.; Brewe, E.; Sutherland, M. T.; Laird, A. R.
10.1101/2021.01.23.427928 — neuroscience — Posted on 2021-01-25
944 Analysis of overlapping genetic association in type 1 and type 2 diabetes
Inshaw, J. R.; Sidore, C.; Cucca, F.; Stefana, M. I.; Crouch, D. J. M.; McCarthy, M. I.; Mahajan, A.; Todd, J. A.
10.1101/2020.06.17.156778 — genetics — Posted on 2021-01-25
947 Chromatin-associated protein complexes link DNA base J and transcription termination in Leishmania
Jensen, B. C.; Phan, I. Q.; McDonald, J. R.; Sur, A.; Gillespie, M. A.; Ranish, J. A.; Parsons, M.; Myler, P. J.
10.1101/2020.05.26.117721 — molecular biology — Posted on 2021-01-25
948 TXN, a Xanthohumol Derivative, Attenuates High-Fat Diet Induced Hepatic Steatosis by Antagonizing PPARγ
Zhang, Y.; Bobe, G.; Miranda, C. L.; Lowry, M. B.; Hsu, V. L.; Löhr, C. V.; Wong, C. P.; Jump, D. B.; Robinson, M. M.; Sharpton, T. J.; Maier, C. S.; Stevens, J. F.; Gombart, A. F.
10.1101/2021.01.11.426043 — molecular biology — Posted on 2021-01-25
949 The CXCR6/CXCL16 axis links inflamm-aging to disease severity in COVID-19 patients
Payne, D. J.; Dalal, S.; Leach, R.; Parker, R.; Griffin, S.; McKimmie, C. S.; Cook, G. P.; Richards, S. J.; Hillmen, P.; Munir, T.; Arnold, L.; Riley, K.; McKinley, C.; Place, S.; Baretto, R. L.; Newton, D. J.
10.1101/2021.01.25.428125 — immunology — Posted on 2021-01-25
952 Rit2 reduces LRRK2 kinase activity and protects against alpha-synuclein neuropathology
Obergasteiger, J.; Castonguay, A.-M.; Frapporti, G.; Lobbestael, E.; Baekelandt, V.; Hicks, A.; Pramstaller, P.; Gravel, C.; Corti, C.; Levesque, M.; Volta, M.
10.1101/2020.10.21.348144 — neuroscience — Posted on 2021-01-25
953 Paradoxical stabilization of relative position in moving frames
Özkan, M.; Anstis, S.; 't Hart, B. M.; Wexler, M.; Cavanagh, P.
10.1101/2021.01.23.427924 — neuroscience — Posted on 2021-01-25
955 Gaining Insight into the Deformation of Achilles Tendon Entheses in Mice
Sartori, J.; Koehring, S.; Bruns, S.; Moosmann, J.; Hammel, J. U.
10.1101/2021.01.23.427898 — zoology — Posted on 2021-01-25
959 FILER: large-scale, harmonized FunctIonaL gEnomics Repository
Kuksa, P. P. P.; Gangadharan, P.; Katanic, Z.; Kleidermacher, L.; Amlie-Wolf, A.; Lee, C.-Y.; Greenfest-Allen, E.; Valladares, O.; Leung, Y. Y.; Wang, L.-S.
10.1101/2021.01.22.427681 — bioinformatics — Posted on 2021-01-25
967 Molecular and evolutionary mechanisms of yeast thermotolerance
Abrams, M. B.; Dubin, C. A.; AlZaben, F.; Bravo, J.; Joubert, P. M.; Weiss, C. V.; Brem, R. B.
10.1101/2020.08.31.275453 — evolutionary biology — Posted on 2021-01-25
970 Upregulated-flotillins and sphingosine kinase 2 derail vesicular trafic to stabilize AXL and promote epithelial-mesenchymal transition
Genest, M.; Comunale, F.; Planchon, D.; Govindin, P.; Vacher, S.; Bieche, I.; Robert, B.; Malhotra, H.; Schoenit, A.; Tashireva, L.; Gauthier-Rouviere, C.; Bodin, S.
10.1101/2020.05.12.090571 — cell biology — Posted on 2021-01-25
971 Massive genome decay and expansion of insertion sequences drive the evolution of a novel host-restricted bacterial pathogen
Yebra, G.; Haag, A. F.; Neamah, M. N.; Wee, B. A.; Richardson, E. J.; Horcajo, P.; Granneman, S.; Tormo-Mas, M. A.; de la Fuente, R.; Fitzgerald, J. R.; Penades, J. R.
10.1101/2020.10.13.331058 — microbiology — Posted on 2021-01-25
974 Bacillus subtilis YngB contributes to wall teichoic acid glucosylation and glycolipid formation during anaerobic growth
Wu, C.-H.; Rismondo, J.; Morgan, R. M. L.; Shen, Y.; Loessner, M. J.; Larrouy-Maumus, G.; Freemont, P. S.; Grundling, A.
10.1101/2020.11.30.405621 — microbiology — Posted on 2021-01-25
975 Sexual dimorphism in outcomes of non-muscle invasive bladder cancer: a role of CD163+ M2 macrophages, B cells and PD-L1 immune checkpoint.
Chenard, S.; Jackson, C.; Vidotto, T.; Chen, L.; Hardy, C.; Jamaspishvilli, T.; Berman, D. M.; Siemens, D. R.; Koti, M.
10.1101/2021.01.23.427909 — immunology — Posted on 2021-01-25
978 Cheetah: a computational toolkit for cybergenetic control
Pedone, E.; de Cesare, I.; Zamora, C.; Haener, D.; Postiglione, L.; La Regina, A.; Shannon, B.; Savery, N.; Grierson, C. S.; di Barnardo, M.; Gorochowski, T. E.; Marucci, L.
10.1101/2020.06.25.171751 — synthetic biology — Posted on 2021-01-25
979 Induction of peri-implantation stage synthetic embryos using reprogramming paradigms in ESCs
Langkabel, J.; Horne, A.; Bonaguro, L.; Hesse, T.; Knaus, A.; Riedel, Y.; Händler, K.; Bassler, K.; Reusch, N.; Yeghiazarian, L. H.; Pecht, T.; Aschenbrenner, A. C.; Kaiser, F.; Kubaczka, C.; Schultze, J. L.; Schorle, H.
10.1101/2021.01.25.428068 — synthetic biology — Posted on 2021-01-25
980 Regulatory signatures of drought response in stress resilient Sorghum bicolor
Parvathaneni, R. K.; Kumar, I.; Braud, M.; Ozersky, P.; Mockler, T. C.; Eveland, A. L.
10.1101/2020.08.07.240580 — plant biology — Posted on 2021-01-25
982 Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity
Ozkan, A.; Stolley, D. L.; Cressman, E. N. K.; McMillin, M.; DeMorrow, S.; Yankeelov, T. E.; Rylander, M. N.
10.1101/2021.01.23.427874 — cancer biology — Posted on 2021-01-25
983 Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia
Takao, S.; Forbes, L.; Uni, M.; Cheng, S.; Pineda, J. M. B.; Tarumoto, Y.; Cifani, P.; Minuesa, G.; Chen, C.; Kharas, M. G.; Bradley, R. K.; Vakoc, C. R.; Koche, R. P.; Kentsis, A.
10.1101/2020.05.05.077156 — cancer biology — Posted on 2021-01-25
988 Reconfiguring primase DNA-recognition sequences by using a data driven approach
Soffer, A.; Ifrach, M.; Ilic, S.; Afek, A.; Schussheim, H.; Vilenchik, D.; Akabayov, B.
10.1101/2020.09.29.317842 — biochemistry — Posted on 2021-01-25
989 Emergence of complex dynamics of choice due to repeated exposures to extinction learning
Donoso, J. R.; Packheiser, J.; Pusch, R.; Lederer, Z.; Walther, T.; Uengoer, M.; Lachnit, H.; Güntürkün, O.; Cheng, S.
10.1101/2020.04.17.046136 — animal behavior and cognition — Posted on 2021-01-25
990 Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes
Vysotskiy, M.; Zhong, X.; Miller-Fleming, T. W.; Zhou, D.; Autism Working Group of the Psychiatric Genomics Consortium, ; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, ; Schizophrenia Working Group of the Psychiatric Genomics Consortium, ; Cox, N. J.; Weiss, L. A.
10.1101/2020.06.23.166181 — genetics — Posted on 2021-01-25
992 From zero to infinity: minimum to maximum diversity of the planet by spatio-parametric Rao's quadratic entropy
Rocchini, D.; Marcantonio, M.; Da Re, D.; Bacaro, G.; Feoli, E.; Foody, G. M.; Harrigan, R. J.; Kleijn, D.; Iannacito, M.; Lenoir, J.; Lin, M.; Malavasi, M.; Marchetto, E.; Meyer, R. S.; Moudry, V.; Schneider, F. D.; Simova, P.; Thornhill, A. H.; Thouverai, E.; Vicario, S.; Wayne, R. K.; Ricotta, C.
10.1101/2021.01.23.427872 — ecology — Posted on 2021-01-25
993 DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as Alk target in the Drosophila visceral mesoderm.
Mendoza-Garcia, P.; Basu, S.; Sukumar, S. K.; Arefin, B.; Wolfstetter, G.; Anthonydhason, V.; Molander, L.; Lindehell, H.; Larsson, J.; Larsson, E. L.; Bemark, M.; Palmer, R. H.
10.1101/2021.01.25.428051 — developmental biology — Posted on 2021-01-25
994 Proteins observed in scalp hair from preschool children
Anand, K. S.; Singhal, K.; Leib, R. D.; Rovnaghi, C. R.; Xenochristou, M.; Chien, A.; Tam, G. K.-Y.; Ruiz, M. O.; Dinakarpandian, D. D.
10.1101/2021.01.22.427851 — developmental biology — Posted on 2021-01-25
996 TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis
Jiang, Z.; Li, W.; Yao, L.-H.; Grewe, B. S.; McGinley, A.; Varga, K.; Alford, S.; Gong, L.-W.
10.1101/2021.01.25.428048 — cell biology — Posted on 2021-01-25
998 Disease-relevant single cell photonic signatures identify S100β stem cells and their myogenic progeny in vascular lesions
Molony, C.; King, D.; di Luca, M.; Kitching, M.; Olayinka, A.; Hakimjavadi, R.; Julius, L. A.; Fitzpatrick, E.; Gusti, Y.; Burtenshaw, D.; Healy, K.; Finlay, E. K.; Kernan, D.; Llobera, A.; Liu, W.; Morrow, D.; Redmond, E. M.; Ducree, J.; Cahill, P. A.
10.1101/2020.05.13.093518 — cell biology — Posted on 2021-01-25
999 Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset
Anand, S. P.; Prevost, J.; Nayrac, M.; Beaudoin-Bussieres, G.; Benlarbi, M.; Gasser, R.; Brassard, N.; Laumaea, A.; Gong, S. Y.; Bourassa, C.; Brunet-Ratnasingham, E.; Medjahed, H.; Gendron-Lepage, G.; Goyette, G.; Gokool, L.; Morrisseau, C.; Begin, P.; Martel-Laferriere, V.; Tremblay, C.; Richard, J.; Bazin, R.; Duerr, R.; Kaufmann, D. E.; Finzi, A.
10.1101/2021.01.25.428097 — microbiology — Posted on 2021-01-25
1001 The CovR regulatory network drives the evolution of Group B Streptococcus virulence
Mazzuoli, M. V.; Daunesse, M.; Varet, H.; Rosinski-Chupin, I.; Legendre, R.; Sismeiro, O.; Gominet, M.; Kaminski, P. A.; Glaser, P.; Chica, C.; Trieu-Cuot, P.; Firon, A.
10.1101/2021.01.25.428120 — microbiology — Posted on 2021-01-25
1002 Design of a novel DNA Gyrase B inhibitor with a rhodanine scaffold: in silico and in vitro approaches
Pudipeddi, A.; Vasudevan, S.; Shanmugam, K.; Stanley, A.; P, V.; Neelakantan, P.; Solomon, A. P.
10.1101/2021.01.24.428017 — microbiology — Posted on 2021-01-25
1003 HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells
Reuschl, A.-K.; Shivkumar, M.; Mesner, D.; Pallett, L. J.; Guerra-Assuncao, J. A.; Madansein, R.; Dullabh, K. J.; Sigal, A.; Thornhill, J. P.; Herrera, C.; Fidler, S.; Noursadeghi, M.; Maini, M.; Jolly, C.
10.1101/2021.01.25.428084 — microbiology — Posted on 2021-01-25
1010 mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge
Meyer, M.; Wang, Y.; Edwards, D.; Smith, G. R.; Rubenstein, A. B.; Ramanathan, P.; Mire, C. E.; Pietzsch, C.; Chen, X.; Ge, Y.; Cheng, W. S.; Henry, C.; Woods, A.; Ma, L.; Stewart-Jones, G. B. E.; Bock, K. W.; Mahnaz, M.; Nagata, B. M.; Periasamy, S.; Shi, P.-Y.; Graham, B. S.; Moore, I. N.; Ramos, I.; Troyanskaya, O. G.; Zaslavsky, E.; Carfi, A.; Sealfon, S. C.; Bukreyev, A.
10.1101/2021.01.25.428136 — immunology — Posted on 2021-01-25
1011 SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice
Yang, K.; Shi, Y.; Du, X.; Zhang, Y.; Shan, S.; Yuan, Y.; Wang, R.; Zhou, C.; Liu, Y.; Cai, Z.; Wang, Y.; Fan, L.; Xu, H.; Yu, J.; Cheng, J.; Li, F.; Qiu, Z.
10.1101/2021.01.24.427868 — neuroscience — Posted on 2021-01-25
1015 Effect of mutations in the SARS-CoV-2 spike protein on protein stability, cleavage, and cell-cell fusion function
Barrett, C. T.; Neal, H. E.; Edmonds, K.; Moncman, C. L.; Thompson, R.; Branttie, J. M.; Boggs, K. B.; Wu, C.-Y.; Leung, D. W.; Dutch, R. E.
10.1101/2021.01.24.428007 — microbiology — Posted on 2021-01-25
1016 Next generation vaccine platform: polymersomes as stable nanocarriers for a highly immunogenic and durable SARS-CoV-2 spike protein subunit vaccine
Lam, J. H.; Khan, A. K.; Cornell, T. A.; Dress, R. J.; Chia, T. W.; Yeow, W. W. W.; Mohd-Ismail, N. K.; Venkatraman, S.; Ng, K. T.; Tan, Y.-J.; Anderson, D. E.; Ginhoux, F.; Nallani, M.
10.1101/2021.01.24.427729 — immunology — Posted on 2021-01-25
1020 Information Enhanced Model Selection for Gaussian Graphical Model with Application to Metabolomic Data
Zhou, J.; Hoen, A.; McRitchie, S.; Pathmasiri, W.; Madan, J.; Viles, W.; Dade, E.; Karagas, M.; Gui, J.
10.1101/815423 — bioinformatics — Posted on 2021-01-25
1021 Identification of LINE retrotransposons and long non-coding RNAs expressed in the octopus brain
Petrosino, G.; Ponte, G.; Volpe, M.; Zarrella, I.; Langella, C.; Di Cristina, G.; Finaurini, S.; Russo, M. T.; Basu, S.; Musacchia, F.; Ristoratore, F.; Pavlinic, D.; Benes, V.; Ferrante, M. I.; Albertin, C.; Simakov, O.; Gustincich, S.; Fiorito, G.; Sanges, R.
10.1101/2021.01.24.427974 — genomics — Posted on 2021-01-25
1024 mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants
Wu, K.; Werner, A. P.; Moliva, J. I.; Koch, M.; Choi, A.; Stewart-Jones, G. B. E.; Bennett, H.; Boyoglu-Barnum, S.; Shi, W.; Graham, B. S.; Carfi, A.; Corbett, K. S.; Seder, R. A.; Edwards, D. K.
10.1101/2021.01.25.427948 — immunology — Posted on 2021-01-25
1025 Homozygosity at its Limit: Inbreeding Depression in Wild Arabidopsis arenosa Populations
Barragan, A. C.; Collenberg, M.; Schwab, R.; Kerstens, M.; Bezrukov, I.; Bemm, F.; Pozarova, D.; Kolar, F.; Weigel, D.
10.1101/2021.01.24.427284 — plant biology — Posted on 2021-01-25
1026 Effects of carbon, nitrogen, phosphorus, and potassium on flowering and Fruiting of Glycyrrhiza uralensis
yan, b.; zhang, y.; Zhang, X.; Wang, S.; Cui, J.; Sun, K.; Wang, T.; Kang, C.; Sun, J.; Ge, Y.; guo, l.; Wang, W.
10.1101/2021.01.23.427937 — plant biology — Posted on 2021-01-25
1028 Discerning amyloid network in plants
Gahane, A. Y.; Sinha, N.; Zahra, T.; Thakur, A. K.
10.1101/2021.01.24.427947 — plant biology — Posted on 2021-01-25
1029 Identification of candidate susceptibility genes to Puccinia graminis f. sp. tritici in wheat
Henningsen, E. C.; Omidvar, V.; Della Coletta, R.; Michno, J.-M.; Gilbert, E.; Li, F.; Miller, M.; Myers, C. L.; Gordon, S. P.; Vogel, J. P.; Steffenson, B. J.; Kianian, S. F.; Hirsch, C. D.; Figueroa, M.
10.1101/2021.01.23.427871 — plant biology — Posted on 2021-01-25
1032 The evolution of Sox gene repertoires and regulation of segmentation in arachnids
Baudouin-Gonzalez, L.; Schoenauer, A.; Harper, A.; Blakeley, G.; Seiter, M.; Arif, S.; Sumner-Rooney, L.; Russell, S.; Sharma, P. P.; McGregor, A. P.
10.1101/2020.06.04.133389 — developmental biology — Posted on 2021-01-25
1033 The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions
Di Luca, M.; Fitzpatrick, E.; Burtenshaw, D.; Liu, W.; Helt, J.-C.; Hakimjavadi, R.; Corcoran, E.; Gusti, Y.; Sheridan, D.; Harman, S.; Lally, C.; Redmond, E. M.; Cahill, P. A.
10.1101/2020.05.20.105981 — cell biology — Posted on 2021-01-25
1034 In vivo visualization of propagating α-synuclein pathologies in mouse and marmoset models by a bimodal imaging probe, C05-05
Ono, M.; Takahashi, M.; Shimozawa, A.; Fujinaga, M.; Mori, W.; Nagai, Y.; Mimura, K.; Minamihisamatsu, T.; Uchida, S.; Kumata, K.; Shimojo, M.; Takado, Y.; Takuwa, H.; Shimizu, H.; Kakita, A.; Sahara, N.; Zhang, M.-R.; Minamimoto, T.; Hasegawa, M.; Higuchi, M.
10.1101/2020.10.23.349860 — neuroscience — Posted on 2021-01-25
1036 The structural connectome constrains fast brain dynamics
Sorrentino, P.; Seguin, C.; Rucco, R.; Liparoti, M.; Troisi Lopez, E.; Bonavita, S.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.; Zalesky, A.
10.1101/2020.11.25.393017 — neuroscience — Posted on 2021-01-25
1037 The Supplementary Eye Field Tracks Cognitive Efforts
Claron, J.; Royo, J.; Arcizet, F.; Deffieux, T.; Tanter, M.; Pouget, P.
10.1101/2021.01.14.426722 — neuroscience — Posted on 2021-01-25
1041 Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes
Wang, Y.; Chiola, S.; Yang, G.; Russell, C.; Armstrong, C. J.; Wu, Y.; Spampanato, J.; Tarboton, P.; Chang, A. N.; Harmin, D. A.; Vezzoli, E.; Besusso, D.; Cui, J.; Cattaneo, E.; Kubanek, J.; Shcheglovitov, A.
10.1101/2021.01.25.428022 — neuroscience — Posted on 2021-01-25
1042 First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays
Gao, F.; Yang, Y.; Zhu, H.; Wang, J.; Xiao, D.; Zhou, Z.; Dai, T.; Zhang, Y.; Feng, G.; Li, J.; Lin, B.; Xie, G.; Ke, Q.; Li, P.; Sheng, X.; Wang, H.; Yan, L.; Lao, C.; Li, M.; Lu, Y.; Zhao, J.; Feng, S.; Du, X.; Wu, D.
10.1101/2020.11.27.401869 — cancer biology — Posted on 2021-01-25
1050 Heterogeneity of murine periosteum progenitors involved in fracture healing
Matthews, B. G.; Novak, S.; Sbrana, F. V.; Funnell, J. L.; Cao, Y.; Buckels, E. J.; Grcevic, D.; Kalajzic, I.
10.1101/2020.06.24.169003 — developmental biology — Posted on 2021-01-24
1055 ENOX2 NADH Oxidase: A BCR-ABL1-dependent cell surface and secreted redox protein in chronic myeloid leukemia (CML)
Baykal Kose, S.; Voldoire, M.; Desterke, C.; Sorel, N.; Cayssials, E.; Johnson-Ansah, H.; Guerci-Bresler, A.; Bennaceur-Griscelli, A.; Chomel, J. C.; Turhan, A. G.
10.1101/2021.01.23.427819 — cancer biology — Posted on 2021-01-24
1057 FIVEx: an interactive multi-tissue eQTL browser
Kwong, A.; Boughton, A.; Wang, M.; VandeHaar, P.; Boehnke, M.; Abecasis, G.; Kang, H. M.
10.1101/2021.01.22.426874 — bioinformatics — Posted on 2021-01-24
1058 Genome-wide analysis of mobile element insertions in human genomes
Niu, Y.; Teng, X.; Shi, Y.; Li, Y.; Tang, Y.; Zhang, P.; Luo, H.; Kang, Q.; The Han100K Initiative, ; Xu, T.; He, S.
10.1101/2021.01.22.427873 — genomics — Posted on 2021-01-24
1061 The CPEB3 ribozyme modulates hippocampal-dependent memory
Chen, C. C.; Han, J.; Chinn, C. A.; Li, X.; Nikan, M.; Myszka, M.; Tong, L.; Bredy, T. W.; Wood, M. A.; Luptak, A.
10.1101/2021.01.23.426448 — molecular biology — Posted on 2021-01-24
1062 Cohesin Releasing Factor WAPL Regulates Genome Structure and Function of Mature T Cells
Sun, Y.; Dotson, G. A.; Muir, L. A.; Ronquist, S.; Oravecz-Wilson, K.; Peltier, D.; Seike, K.; Li, L.; Meixner, W.; Rajapakse, I.; Reddy, P.
10.1101/2021.01.23.427857 — molecular biology — Posted on 2021-01-24
1065 Automatic classification of ICA components from infant EEG using MARA
Marriott Haresign, I.; Phillips, E.; Whitehorn, M.; Noreika, V.; Jones, E.; Leong, V.; Wass, S. V.
10.1101/2021.01.22.427809 — neuroscience — Posted on 2021-01-24
1066 The retrosplenial cortex combines internal and external cues to encode head velocity during navigation
Keshavarzi, S.; Bracey, E. F.; Faville, R. A.; Campagner, D.; Tyson, A. L.; Lenzi, S. C.; Branco, T.; Margrie, T. W.
10.1101/2021.01.22.427789 — neuroscience — Posted on 2021-01-24
1068 Cancer Hallmarks Define a Continuum of Plastic Cell States between Small Cell Lung Cancer Archetypes
Groves, S. M.; Ireland, A.; Liu, Q.; Simmons, A. J.; Lau, K.; Iams, W. T.; Tyson, D. R.; Lovly, C.; Oliver, T. G.; Quaranta, V.
10.1101/2021.01.22.427865 — systems biology — Posted on 2021-01-24
1071 REM: An Integrative Rule Extraction Methodology for Explainable Data Analysis in Healthcare
Shams, Z.; Dimanov, B.; Kola, S.; Simidjievski, N.; Andres Terre, H.; Scherer, P.; Matjasec, U.; Abraham, J.; Lio, P.; Jamnik, M.
10.1101/2021.01.22.427799 — bioinformatics — Posted on 2021-01-24
1073 Genome evolution of a non-parasitic secondary heterotroph, the diatom Nitzschia putrida
Kamikawa, R.; Mochizuki, T.; Sakamoto, M.; Tanizawa, Y.; Nakayama, T.; Onuma, R.; Cenci, U.; Moog, D.; Speak, S.; Sarkozi, K.; Toseland, A.; van Oosterhout, C.; Oyama, K.; Kato, M.; Kume, K.; Kayama, M.; Azuma, T.; Ishii, K.-i.; Miyashita, H.; Henrissat, B.; Lombard, V.; Win, J.; Kamoun, S.; Kashiyama, Y.; Mayama, S.; Miyagishima, S.-y.; Tanifuji, G.; Mock, T.; Nakamura, Y.
10.1101/2021.01.24.427197 — genomics — Posted on 2021-01-24
1074 Hi-C Analyses with GENOVA: a case study with cohesin variants
van der Weide, R. H.; van den Brand, T.; Haarhuis, J. H.; Teunissen, H.; Rowland, B.; de Wit, E.
10.1101/2021.01.22.427620 — genomics — Posted on 2021-01-24
1075 Long-read metagenomics of soil communities reveals phylum-specific secondary metabolite dynamics
Van Goethem, M. W.; Osborn, A. R.; Bowen, B.; Andeer, P. F.; Swenson, T. L.; Clum, A.; Riley, R.; He, G.; Koriabine, M.; Sandor, L. C.; Yan, M.; Daum, C. G.; Yoshinaga, Y.; Makhalanyane, T. P.; Garcia-Pichel, F. P.; Visel, A.; Pennacchio, L.; O'Malley, R. C.; Northen, T. R.
10.1101/2021.01.23.426502 — genomics — Posted on 2021-01-24
1076 Local adaptations of Mediterranean sheep and goats through an integrative approach
Serranito, B.; Cavalazzi, M.; Vidal, P.; Taurisson-Mouret, D.; Ciani, E.; Bal, M.; Rouvellac, E.; Servin, B.; Moreno-Romieux, C.; Tosser-Klopp, G.; Hall, S.; Lenstra, J. A.; Pompanon, F.; Benjelloun, B.; DA SILVA, A.
10.1101/2021.01.22.427461 — evolutionary biology — Posted on 2021-01-24
1077 MAESTRO affords 'breadth and depth' for mutation testing
Gydush, G.; Nguyen, E.; Bae, J. H.; Rhoades, J.; Reed, S. C.; Shea, D.; Xiong, K.; Liu, R.; Blewett, T.; Yu, F.; Leong, K. W.; Choudhury, A. D.; Stover, D. G.; Tolaney, S. M.; Krop, I. E.; Love, J. C.; Parsons, H. A.; Makrigiorgos, G. M.; Golub, T. R.; Adalsteinsson, V. A.
10.1101/2021.01.22.427323 — molecular biology — Posted on 2021-01-24
1078 Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant
Reuschl, A.-K.; Thorne, L.; Zuliani Alvarez, L.; Bouhaddou, M.; Obernier, K.; Soucheray, M.; Turner, J.; Fabius, J.; Nguyen, G. T.; Swaney, D.; Rosales, R.; White, K. M.; Aviles, P.; Kirby, I. T.; Melnyk, J. E.; Shi, Y.; Zhang, Z.; Shokat, K.; Garcia-Sastre, A.; Jolly, C.; Towers, G. J.; Krogan, N. J.
10.1101/2021.01.24.427991 — microbiology — Posted on 2021-01-24
1084 Mechanisms of lactic acid gustatory attraction in Drosophila
Stanley, M.; Ghosh, B.; Weiss, Z. F.; Christiaanse, J.; Gordon, M. D.
10.1101/2021.01.22.427705 — neuroscience — Posted on 2021-01-24
1085 A Novel Swine Model of the Acute Respiratory Distress Syndrome Using Clinically-Relevant Injury Exposures
Tiba, M. H.; McCracken, B. M.; Leander, D. C.; Colmenaro, C. I.; Nemzek, J. A.; Sjoding, M. W.; Konopka, K. E.; Flott, T. L.; VanEpps, J. S.; Daniels, R.; Ward, K. R.; Stringer, K. A.; Dickson, R. P.
10.1101/2021.01.24.427964 — pathology — Posted on 2021-01-24
1089 CD8+ T cell epitope variations suggest a potential antigen presentation deficiency for spike protein of SARS-CoV-2
Qiu, C.; Xiao, C.; Wang, Z.; Zhu, G.; Chen, X.; Gao, L.; Den, J.; Su, J.; Su, H.; Fang, E. F.; Zhang, Z.; Zhang, J.; Luo, O. J.; Wang, P.; Chen, G.
10.1101/2021.01.22.427863 — immunology — Posted on 2021-01-24
1092 Remodeling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis
Tamamouna, V.; Rahman, M. M.; Petersson, M.; Charalambous, I.; Kux, K.; Mainor, H.; Bolender, V.; Isbilir, B.; Edgar, B. A.; Pitsouli, C.
10.1101/2021.01.23.427889 — cell biology — Posted on 2021-01-24
1093 Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1
Yamawaki, N.; Raineri Tapies, M. G.; Stults, A. M.; Smith, G. A.; Shepherd, G. M. G.
10.1101/2021.01.22.427843 — neuroscience — Posted on 2021-01-24
1096 Molecular basis of small-molecule binding to α-synuclein
Robustelli, P.; Ibanez-de-Opakua, A.; Campbell-Bezat, C.; Giordanetto, F.; Becker, S.; Zweckstetter, M.; Pan, A. C.; Shaw, D. E.
10.1101/2021.01.22.426549 — biophysics — Posted on 2021-01-24
1097 Large field of view-spatially resolved transcriptomics at nanoscale resolution
Chen, A.; Liao, S.; Cheng, M.; Ma, K.; Wu, L.; Lai, Y.; Yang, J.; Li, W.; Xu, J.; Hao, S.; Lu, H.; Chen, X.; Liu, X.; Huang, X.; Lin, F.; Tang, X.; Li, Z.; Hong, Y.; Fu, D.; Jiang, Y.; Peng, J.; Liu, S.; Shen, M.; Liu, C.; Li, Q.; Wang, Z.; Wang, Z.; Huang, X.; Yuan, Y.; Volpe, G.; Ward, C.; Munoz-Canoves, P.; Thiery, J. P.; Zhao, F.; Li, M.; Kuang, H.; Wang, O.; Lu, H.; Wang, B.; Ni, M.; Zhang, W.; Mu, F.; Yin, Y.; Yang, H.; Lisby, M.; Cornall, R. J.; Uhlen, M.; Esteban, M. A.; Li, Y.; Liu, L.; Xu, X.; Wang, J.
10.1101/2021.01.17.427004 — cell biology — Posted on 2021-01-24
1100 Longitudinal Auditory Pathophysiology Following Mild Blast Induced Trauma
Han, E. X.; Fernandez, J. M.; Swanberg, C.; Shi, R.; Bartlett, E. L.
10.1101/2020.11.06.371591 — neuroscience — Posted on 2021-01-24
1101 SSnet: A Deep Learning Approach for Protein-Ligand Interaction Prediction
Verma, N.; Qu, X.; Trozzi, F.; Elsaied, M.; Karki, N.; Tao, Y.; Zoltowski, B. D.; Larson, E.; Kraka, E.
10.1101/2019.12.20.884841 — bioinformatics — Posted on 2021-01-24
1104 Convergent consequences of parthenogenesis on stick insect genomes
Jaron, K. S.; Parker, D. J.; Anselmetti, Y.; Tran Van, P.; Bast, J.; Dumas, Z.; Figuet, E.; Francois, C. M.; Hayward, K.; Rossier, V.; Simion, P.; Robinson-Rechavi, M.; Galtier, N.; Schwander, T.
10.1101/2020.11.20.391540 — evolutionary biology — Posted on 2021-01-24
1105 Nanobody Mediated Macromolecular Crowding Induces Membrane Fission and Remodeling in the African Trypanosome
Hempelmann, A.; Hartleb, L.; Van Straaten, M.; Hashemi, H.; Zeelen, J. P.; Papavasiliou, F. N.; Engstler, M.; Stebbins, C. E.; Jones, N. G.
10.1101/2021.01.13.426364 — microbiology — Posted on 2021-01-24
1106 Can we improve slow learning in cerebellar patients?
Hulst, T.; Mamlins, A.; Frens, M.; Chang, D.-I.; Goericke, S. L.; Timmann, D.; Donchin, O.
10.1101/2020.07.03.185959 — neuroscience — Posted on 2021-01-24
1109 Transcriptome variation in human tissues revealed by long-read sequencing
Glinos, D. A.; Garborcauskas, G.; Hoffman, P.; Ehsan, N.; Jiang, L.; Gokden, A.; Dai, X.; Aguet, F.; Brown, K. L.; Garimella, K.; Bowers, T.; Costello, M.; Ardlie, K.; Jian, R.; Tucker, N. R.; Ellinor, P. T.; Harrington, E. D.; Tang, H.; Snyder, M.; Juul, S.; Mohammadi, P.; MacArthur, D. G.; Lappalainen, T.; Cummings, B.
10.1101/2021.01.22.427687 — genomics — Posted on 2021-01-23
1111 Developmental and behavioral phenotypes in a new mouse model of DDX3X syndrome
Boitnott, A.; Ung, D.; Garcia-Forn, M.; Niblo, K.; Mendonca, D.; Flores, M.; Maxwell, S.; Ellegood, J.; Qiu, L. R.; Grice, D. E.; Lerch, J. P.; Rasin, M.-R.; Buxbaum, J. D.; Drapeau, E.; De Rubeis, S.
10.1101/2021.01.22.427482 — neuroscience — Posted on 2021-01-23
1113 A prioritized and validated resource of mitochondrial proteins in Plasmodium identifies leads to unique biology
van Esveld, S. L.; Meerstein-Kessel, L.; Boshoven, C.; Baaij, J.; Barylyuk, K.; Coolen, J.; Duim, R. A. J.; Dutilh, B. E.; Garza, D. R.; Letterie, M.; Proellochs, N. I.; de Ridder, M. N.; Venkatasubramanian, P. B.; de Vries, L. E.; Waller, R. F.; Kooij, T. W. A.; Huynen, M. A.
10.1101/2021.01.22.427784 — bioinformatics — Posted on 2021-01-23
1116 Evolutionarily conserved transcriptional landscape of the heart defining the chamber specific physiology
Gandhi, S.; Witten, A.; deMajo, F.; Gilbers, M.; Maessen, J. G.; Schotten, U.; de Windt, L.; Stoll, M.
10.1101/2021.01.22.427752 — genomics — Posted on 2021-01-23
1119 Why are viral genomes so fragile? The bottleneck hypothesis
Merleau, N. S. C.; Penisson, S.; Gerrish, P. J.; Elena, S. F.; Smerlak, M.
10.1101/2021.01.23.427881 — evolutionary biology — Posted on 2021-01-23
1122 Phosphorylation of JIP4 at S730 presents anti-viral properties against influenza A virus infection
Del Sarto, J.; Gerlt, V.; Friedrich, M. E.; Anhlan, D.; Wixler, V.; Teixeira, M. M.; Boergeling, Y.; Ludwig, S.
10.1101/2021.01.22.427772 — microbiology — Posted on 2021-01-23
1124 Metabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile
Tremblay, Y. D.; Durand, B. A.; Hamiot, A.; Martin-Verstraete, I.; Oberkampf, M.; Monot, M.; Dupuy, B.
10.1101/2021.01.23.427917 — microbiology — Posted on 2021-01-23
1126 Quantitative coupling of cell volume and membrane tension during osmotic shocks
Roffay, C.; Molinard, G.; Kim, K.; Barbarassa, V.; Urbanska, M.; Mercier, V.; Garcia Calvo, J.; Matile, S.; Guck, J.; Lenz, M.; Roux, A.
10.1101/2021.01.22.427801 — biophysics — Posted on 2021-01-23
1129 Ancient genomes reveal long range influence of the site and culture of Tiwanaku
Popovic, D.; Molak, M.; Ziolkowski, M.; Vranich, A.; Sobczyk, M.; Vidaurre, D. U.; Agresti, G.; Skrzypczak, M.; Ginalski, K.; Lamnidis, T. C.; Nakatsuka, N. J.; Mallick, S.; Baca, M.
10.1101/2021.01.22.427554 — genomics — Posted on 2021-01-23
1130 A genetic variant alters the secondary structure of the lncRNA H19 and is associated with Dilated Cardiomyopathy
Martens, L.; Ruehle, F.; Witten, A.; Meder, B.; Katus, H. A.; Arbustini, E.; Hasenfuss, G.; Sinner, M. F.; Kaab, S.; Pankuweit, S.; Angermann, C.; Bornberg-Bauer, E.; Stoll, M.
10.1101/2021.01.22.427739 — genetics — Posted on 2021-01-23
1134 A targeted and tuneable DNA damage tool using CRISPR/Cas9.
Emmanouilidis, I.; Fili, N.; Cook, A.; Hari-Gupta, Y.; dos Santos, A.; Wang, L.; Martin-Fernandez, M. L.; Ellis, P. J.; Toseland, C. P.
10.1101/2021.01.23.427907 — cell biology — Posted on 2021-01-23
1140 Anaerobic Benzene Biodegradation Linked to Growth of Highly Specific Bacterial Clades
Toth, C.; Luo, F.; Bawa, N.; Webb, J.; Guo, S.; Dworatzek, S.; Edwards, E. A.
10.1101/2021.01.23.427911 — microbiology — Posted on 2021-01-23
1142 Oral epithelial cells distinguish between Candida species with high or low pathogenic potential through miRNA regulation
Horvath, M.; Nagy, G.; Zsindely, N.; Bodai, L.; Horvath, P.; Vagvolgyi, C.; Nosanchuk, J. D.; Toth, R.; Gacser, A.
10.1101/2021.01.23.427558 — microbiology — Posted on 2021-01-23
1143 Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination
Zarnitsyna, V. I.; Akondy, R. S.; Ahmed, H.; McGuire, D. J.; Zarnitsyn, V. G.; Moore, M.; Johnson, P. L. F.; Ahmed, R.; Li, K.; Hellerstein, M.; Antia, R.
10.1101/2021.01.23.427919 — immunology — Posted on 2021-01-23
1144 Dynamics in Natural and Designed Elastins and Their Relation to Elastic Fiber Structure and Recoil
Carvajal, M. F. C. A.; Preston, J. M.; Jamhawi, N. M.; Sabo, T. M.; Bhattacharya, S.; Aramini, J. M.; Wittebort, R. J.; Koder, R.
10.1101/2020.07.14.202523 — biophysics — Posted on 2021-01-23
1146 Whole Animal Multiplexed Single-Cell RNA-Seq Reveals Plasticity of Clytia Medusa Cell Types
Chari, T.; Weissbourd, B.; Gehring, J.; Ferraioli, A.; Leclere, L.; Herl, M.; Gao, F.; Chevalier, S.; Copley, R. R.; Houliston, E.; Anderson, D. J.; Pachter, L.
10.1101/2021.01.22.427844 — systems biology — Posted on 2021-01-23
1147 ENHANCED GRAVITROPISM 2 encodes a STERILE ALPHA MOTIVE containing protein that controls root growth angle in barley and wheat
Kirschner, G. K.; Rosignoli, S.; Vardanega, I.; Guo, L.; Imani, J.; Altmueller, J.; Milner, S. G.; Balzano, R.; Nagel, K. A.; Pflugfelder, D.; Forestan, C.; Bovina, R.; Koller, R.; Stoecker, T. G.; Mascher, M.; Simmonds, J.; Uauy, C.; Schoof, H.; Tuberosa, R.; Salvi, S.; Hochholdinger, F.
10.1101/2021.01.23.427880 — plant biology — Posted on 2021-01-23
1149 Characterization of extracellular vesicles and artificial nanoparticles with four orthogonal single-particle analysis platforms
Arab, T.; Mallick, E. R.; Huang, Y.; Dong, L.; Liao, Z.; Zhao, Z.; Gololobova, O.; Smith, B.; Haughey, N. J.; Pienta, K. J.; Slusher, B. S.; Tarwater, P. M.; Tosar, J. P.; Zivkovic, A. M.; Vreeland, W. N.; Paulaitis, M. E.; Witwer, K. W.
10.1101/2020.08.04.237156 — cell biology — Posted on 2021-01-23
1152 Nef dimerization defect abrogates HIV viremia and associated immune dysregulation in the Bone Marrow-Liver-Thymus-Spleen (BLTS) humanized mouse model
Biradar, S.; Agarwal, Y.; Das, A.; Shu, S. T.; Samal, J.; Ho, S.; Beatty, C.; Castronova, I.; Mailliard, R. B.; Smithgall, T. E.; Bility, M. T.
10.1101/2021.01.21.427631 — immunology — Posted on 2021-01-23
1158 Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback
Lopacinski, A. B.; Sweatt, A. J.; Smolko, C. M.; Gray-Gaillard, E.; Borgmann, C. A.; Shah, M.; Janes, K. A.
10.1101/2020.07.26.222174 — systems biology — Posted on 2021-01-23
1161 THE REGULATORY EFFECT OF LIGHT OVER FRUIT DEVELOPMENT AND RIPENING IS MEDIATED BY EPIGENETIC MECHANISMS
Bianchetti, R.; Bellora, N.; de Haro, L.; Zuccarelli, R.; Rosado, D.; Freschi, L.; Rossi, M.; Bermudez, L. F.
10.1101/2020.07.30.227447 — plant biology — Posted on 2021-01-23
1162 Lineage and Spatial Mapping of Glioblastoma-associated Immunity
Ravi, V. M.; Neidert, N.; Will, P.; Joseph, K.; Kuekelhaus, J.; Vollmer, L.; Goeldner, J.; Behringer, S.; Scherer, F.; Boerries, M.; Follo, M.; Weiss, T.; Delev, D.; Kernbach, J.; Franco, P.; Schallner, N.; Scheiwe, C.; Carro, M. S.; Hofmann, U. G.; Fung, C.; Beck, J.; Sankowski, R.; Prinz, M.; Schnell, O.; Heiland, D. H.
10.1101/2020.06.01.121467 — cancer biology — Posted on 2021-01-23
1165 Functional repertoire convergence of distantly related eukaryotic plankton lineages revealed by genome-resolved metagenomics
Delmont, T. O.; Gaia, M.; Hinsinger, D. D.; Fremont, P.; Vanni, C.; Fernandez Guerra, A.; Eren, A. M.; Kourlaiev, A.; d'Agata, L.; Clayssen, Q.; Villar, E.; Labadie, K.; Cruaud, C.; Poulain, J.; Da Silva, C.; Wessner, M.; Noel, B.; Aury, J.-M.; Coordinators, T. O.; de Vargas, C.; Bowler, C.; Karsenti, E.; Pelletier, E.; Wincker, P.; Jaillon, O.
10.1101/2020.10.15.341214 — microbiology — Posted on 2021-01-23
1170 Social prediction modulates activity of macaque superior temporal cortex
Roumazeilles, L.; Schurz, M.; Lojkiewiez, M.; Verhagen, L.; Schuffelgen, U.; Marche, K.; Mahmoodi, A.; Emberton, A.; Simpson, K.; Joly, O.; Khamassi, M.; Rushworth, M. F.; Mars, R. B.; Sallet, J.
10.1101/2021.01.22.427803 — neuroscience — Posted on 2021-01-23
1172 Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing
Timmers, P. R. H. J.; Tiys, E. S.; Sakaue, S.; Akiyama, M.; Kiiskinen, T. T. J.; Zhou, W.; Hwang, S.-J.; Yao, C.; The Biobank Japan Project, ; FinnGen Study, ; Deelen, J.; Levy, D.; Ganna, A.; Okada, Y.; Joshi, P. K.; Wilson, J. F.; Tsepilov, Y. A.
10.1101/2021.01.22.427837 — genomics — Posted on 2021-01-23
1173 Polycomb suppresses a female gene regulatory network in Sertoli cells
Maezawa, S.; Yukawa, M.; Hasegawa, K.; Sugiyama, R.; Hu, M.; Vidal, M.; Koseki, H.; Barski, A.; DeFalco, T.; Namekawa, S. H.
10.1101/2021.01.19.427322 — developmental biology — Posted on 2021-01-22
1176 Dopamine transporter is a master regulator of dopaminergic neural network connectivity
Miller, D. R.; Guenther, D. T.; Maurer, A. P.; Hansen, C. A.; Zalesky, A.; Khoshbouei, H.
10.1101/2021.01.22.427804 — neuroscience — Posted on 2021-01-23
1178 Effect of hydroxyapatite microspheres, amoxicillin-hydroxyapatite and collagen-hydroxyapatite composites on human dental pulp-derived mesenchymal stem cells
Pupo, Y. M.; Leite, L. M. B.; Senegaglia, A. C.; Antunes, L.; Nadal, J. M.; de Lara, E. L.; Saito, R. E.; Antunes, S. R. M.; Farago, P. V.
10.1101/2021.01.22.427754 — cell biology — Posted on 2021-01-22
1179 Forecasting the future risk of dengue epidemics facing climate change in New Caledonia, South Pacific.
OCHIDA, N.; Mangeas, M.; Myrielle, D.-R.; Dutheil, C.; Forfait, C.; Pelletier, A.; Descloux, E.; Menkes, C.
10.1101/2021.01.22.427761 — microbiology — Posted on 2021-01-22
1183 Effects of Endogenous Angiotensin II on Abdominal Aortic Aneurysms and Atherosclerosis in Angiotensin II-infused Mice
Kukida, M.; Sawada, H.; Ohno-Urabe, S.; Howatt, D. A.; Moorleghen, J. J.; Poglitsch, M.; Daugherty, A.; Lu, H. S.
10.1101/2020.11.18.377416 — pathology — Posted on 2021-01-22
1194 High Throughput Computational Mouse Genetic Analysis
Arslan, A.; GUAN, Y.; Chen, X.; Zhu, W.; Wu, M.; Zheng, M.; Dill, D. L.; Peltz, G.; Donaldson, R.; Ford, M.; Fang, Z.
10.1101/2020.09.01.278465 — bioinformatics — Posted on 2021-01-22
1198 Characterisation of the RNA-interference pathway as a Tool for Genetics in the Nascent Phototrophic Endosymbiosis, Paramecium bursaria
Jenkins, B. H.; Maguire, F.; Leonard, G.; Eaton, J. D.; West, S.; Housden, B. E.; Milner, D. S.; Richards, T. A.
10.1101/2020.12.16.423098 — molecular biology — Posted on 2021-01-22
1199 γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release.
Hu, M. D.; Golovchenko, N. B.; Kelly, T. J.; Agos, J.; Zeglinski, M. R.; Bonder, E. M.; Sandrock, I.; Prinz, I.; Granville, D. J.; Watson, A. J. M.; Edelblum, K. L.
10.1101/2021.01.20.427150 — immunology — Posted on 2021-01-22
1200 Investigating the spectral features of the brain meso-scale structure at rest
Iandolo, R.; Semprini, M.; Sona, D.; Mantini, D.; Avanzino, L.; Chiappalone, M.
10.1101/2020.05.26.114488 — neuroscience — Posted on 2021-01-22
1202 CloudBrain: Online neural computation in the cloud
Larsen, L. B.; Stagsted, R.; Strohmer, B.; Christensen, A. L.
10.1101/2021.01.21.427662 — neuroscience — Posted on 2021-01-22
1205 Single cell transcriptomic analysis identifies Langerhans cells immunocompetency is critical for ability to induce tolerogenic T cells.
Davies, J.; Sirvent, S.; Vallejo, A. F.; Clayton, K.; Porter, G.; Stumpf, P.; West, J.; Ardern-Jones, M.; Singh, H.; MacArthur, B.; Polak, M. E.
10.1101/2019.12.20.884130 — systems biology — Posted on 2021-01-22
1208 Automatic wound detection and size estimation using deep learning algorithms
Carrion, H.; Jafari, M.; Bagood, M. D.; Yang, H.-y.; Isseroff, R. R.; Gomez, M.
10.1101/2020.11.13.275917 — bioinformatics — Posted on 2021-01-22
1213 Unique features of stimulus-based probabilistic reversal learning
Harris, C.; Aguirre, C. G.; Kolli, S.; Das, K.; Izquierdo, A.; Soltani, A.
10.1101/2020.09.24.310771 — animal behavior and cognition — Posted on 2021-01-22
1218 Quantitative Mapping of Human Hair Graying and Reversal in Relation to Life Stress
Rosenberg, A.; Rausser, S.; Ren, J.; Mosharov, E.; Sturm, G. M.; Ogden, R. T.; Patel, P.; Soni, R. K.; Lacefield, C.; Tobin, D. J.; Paus, R.; Picard, M.
10.1101/2020.05.18.101964 — cell biology — Posted on 2021-01-22
1219 Helicase-Like Functions in Phosphate Loop Containing Beta-Alpha Polypeptides
Vyas, P.; Trofimyuk, O.; Longo, L. M.; Deshmukh, F. K.; Sharon, M.; Tawfik, D. S.
10.1101/2020.07.30.228619 — molecular biology — Posted on 2021-01-22
1224 Linear-Nonlinear Cascades Capture Synaptic Dynamics
Rossbroich, J.; Trotter, D.; Beninger, J.; Toth, K.; Naud, R.
10.1101/2020.06.04.133892 — neuroscience — Posted on 2021-01-22
1231 Direct imaging of anthrax intoxication in animals reveals shared and individual functions of CMG-2 and TEM-8 in cellular toxin entry
Merritt, C.; Chun, E. M.; Fattah, R. J.; Moayeri, M.; Paliga, D.; Neumann, S.; Heumann, R.; Leppla, S. H.; Bugge, T. H.
10.1101/2021.01.22.427304 — pathology — Posted on 2021-01-22
1232 MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells
Zanotti, S.; Vanhauwaert, S.; Van Neste, C.; Olexiouk, V.; Van Laere, J.; Verschuuren, M.; Mus, L. M.; Durinck, K.; Tilleman, L.; Deforce, D.; Van Nieuwerburgh, F.; Hogarty, M. D.; Decaesteker, B.; De Vos, W. H.; Speleman, F.
10.1101/2021.01.22.427454 — cancer biology — Posted on 2021-01-22
1233 Neoplastic and Immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.
Riemondy, K. A.; Venkataraman, S.; Willard, N.; Nellan, A.; Sanford, B.; Griesinger, A. M.; Amani, V.; Mitra, S.; Hankinson, T. C.; Handler, M. H.; Sill, M.; Ocasio, J.; Weir, S. J.; Malawsky, D. S.; Gershon, T. R.; Garancher, A.; Wechsler-Reya, R. J.; Hesselberth, J. R.; Foreman, N. K.; Donson, A. M.; Vibhakar, R.
10.1101/2020.08.28.272021 — cancer biology — Posted on 2021-01-22
1235 Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
van Dorp, S.; Qiu, R.; Choi, U. B.; Wu, M. M.; Yen, M.; Kirmiz, M.; Brunger, A. T.; Lewis, R. S.
10.1101/2020.12.17.423361 — biophysics — Posted on 2021-01-22
1242 Performance of a scalable extraction-free RNA-seq method
Ghimire, S.; Stewart, C. G.; Thurman, A. L.; Pezzulo, A. A.
10.1101/2021.01.22.427817 — genomics — Posted on 2021-01-22
1243 Fast but not furious: a streamlined selection method for genome edited cells
Ramachandran, H.; Martins, S.; Kontarakis, Z.; Krutmann, J.; Rossi, A.
10.1101/2021.01.22.427783 — genomics — Posted on 2021-01-22
1244 Exploring the natural origins of SARS-CoV-2
Lytras, S.; Hughes, J.; Xia, W.; Jiang, X.; Robertson, D. L.
10.1101/2021.01.22.427830 — evolutionary biology — Posted on 2021-01-22
1246 An exceptionally preserved euarthropod with unique feather-like appendages from the Chengjiang biota
Zhai, D. Y.; Williams, M.; Siveter, D. J.; Siveter, D. J.; Harvey, T. H. P.; Sansom, R. S.; Mai, H.; Zhou, R.; Hou, X.
10.1101/2021.01.22.427827 — evolutionary biology — Posted on 2021-01-22
1247 Fine-scale Population Structure of North American Arabidopsis thaliana Reveals Multiple Sources of Introduction from Across Eurasia
Shirsekar, G.; Devos, J.; Latorre, S. M.; Blaha, A.; Queiroz Dias, M.; Gonzalez Hernando, A.; Lundberg, D. S.; Burbano, H. A.; Fenster, C. B.; Weigel, D.
10.1101/2021.01.22.427575 — evolutionary biology — Posted on 2021-01-22
1251 Burkholderia from fungus gardens of fungus-growing ants produce antifungals that inhibit the specialized parasite Escovopsis
Francoeur, C. B.; May, D. S.; Thairu, M.; Hoang, D. Q.; Panthofer, O.; Bugni, T. S.; Pupo, M. T.; Clardy, J.; Pinto-Tomas, A. A.; Currie, C. R.
10.1101/2021.01.22.427492 — microbiology — Posted on 2021-01-22
1261 The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity
Smit, M. J.; Armandari, I.; Bockaj, I.; Martini, T. E. I.; Zomerman, W. W.; Siragna, Z.; Meeuwsen-de Boer, T. G. J.; Scherpen, F. J. G.; Schoots, M. H.; Ritsema, M.; den Dunnen, W. F. A.; Hoving, E. H.; Paridaen, J. T. M. L.; de Haan, G.; Guryev, V.; Bruggeman, S.
10.1101/2021.01.22.427790 — cancer biology — Posted on 2021-01-22
1263 Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies
Hu, J.; Peng, P.; Wang, K.; Liu, B.-z.; Fang, L.; Luo, F.-y.; Jin, A.-s.; Tang, N.; Huang, A.
10.1101/2021.01.22.427749 — microbiology — Posted on 2021-01-22
1264 Succinate Dehydrogenase (SDH)-subunit C regulates muscle oxygen consumption and fatigability in an animal model of pulmonary emphysema.
Balnis, J.; Drake, L.; Vincent, C.; Korponay, T. C.; Singer, D.; Lacomis, D.; Lee, C. G.; Elias, J.; Singer, H. A.; Jaitovich, A.
10.1101/2021.01.22.427763 — physiology — Posted on 2021-01-22
1266 The Arabidopsis pattern recognition receptor EFR enhances fire blight resistance in apple
Piazza, S.; Campa, M.; Pompili, V.; Costa, L. D.; Salvagnin, U.; Nekrasov, V.; Zipfel, C.; Malnoy, M.
10.1101/2021.01.22.427734 — plant biology — Posted on 2021-01-22
1267 The Arabidopsis immune receptor EFR increases resistance to the bacterial pathogens Xanthomonas and Xylella in transgenic sweet orange
Mitre, L. K.; Teixeira-Silva, N. S.; Rybak, K.; Magalhaes, D. M.; de Souza-Neto, R. R.; Robatzek, S.; Zipfel, C.; De Souza, A. A.
10.1101/2021.01.22.427732 — plant biology — Posted on 2021-01-22
1268 Improvements in the Sequencing and Assembly of Plant Genomes
Sharma, P.; Aldossary, O.; Alsubaie, B.; Al-Mssallem, I.; Nath, O.; Mitter, N.; Margarido, G.; Topp, B.; Murigneux, V.; Masouleh, A.; Furtado, A.; Henry, R. J.
10.1101/2021.01.22.427724 — genomics — Posted on 2021-01-22
1270 PIKfyve inhibition blocks endolysosomal escape of α-synuclein fibrils and spread of α-synuclein aggregation
See, S. K.; Chen, M.; Bax, S.; Tian, R.; Woerman, A.; Tse, E.; Johnson, I. E.; Nowotny, C.; Munoz, E. N.; Sengstack, J.; Southworth, D. R.; Gestwicki, J. E.; Leonetti, M. D.; Kampmann, M.
10.1101/2021.01.21.427704 — cell biology — Posted on 2021-01-22
1271 Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoforms
Iv, F.; Silva Martins, C.; Castro-Linares, G.; Taveneau, C.; Barbier, P.; Verdier-Pinard, P.; Camoin, L.; Audebert, S.; Tsai, F.-C.; Ramond, L.; Llewellyn, A.; Belhabib, M.; Nakazawa, K.; Di Cicco, A.; Vincentelli, R.; Wenger, J.; Cabantous, S.; Koenderink, G.; Bertin, A.; Mavrakis, M.
10.1101/2021.01.21.427698 — cell biology — Posted on 2021-01-22
1272 A two-color haploid genetic screen identifies novel host factors involved in HIV latency
Röling, M.; Mollapour Sisakht, M.; Ne, E.; Moulos, P.; Stoszko, M.; De Crignis, E.; Bodmer, H.; Kan, T. W.; Akbarzadeh, M.; Harokopos, V.; Hatzis, P.; Palstra, R.-J.; Mahmoudi, T.
10.1101/2021.01.20.427543 — molecular biology — Posted on 2021-01-22
1273 RNAi screening reveals requirement for PDGFRβ in JEV infection.
Zhou, M.; Wang, S.; Guo, J.; Liu, Y.; Cao, J.; Lan, X.; Jia, X.; Zhang, B.; Xiao, G.; Wang, W.
10.1101/2021.01.21.427722 — microbiology — Posted on 2021-01-22
1275 Comparative investigation of the Diabetic foot ulcer microbiome
Saeb, A. T. M.; Tayeb, H. T.; Ouizi, S.; nassar, M.; Alfadda, A. A.; Raja G., U.; mani, B. v.; Youssef, A.; ALSUABEYL, M. S.
10.1101/2021.01.21.427721 — microbiology — Posted on 2021-01-22
1276 Huygens synchronization of medial septal pacemaker neurons generates hippocampal theta oscillation
Kocsis, B.; Martinez-Bellver, S.; Fiath, R.; Domonkos, A.; Sviatko, K.; Bartho, P.; Freund, T. F.; Ulbert, I.; Kali, S.; Varga, V.; Hangya, B.
10.1101/2021.01.22.427736 — neuroscience — Posted on 2021-01-22
1278 A parsimonious model for mass-univariate vertex-wise analysis
Couvy-Duchesne, B.; Zhang, F.; Kemper, K. E.; Sidorenko, J.; Wray, N. R.; Visscher, P. M.; Colliot, O.; Yang, J.
10.1101/2021.01.22.427735 — neuroscience — Posted on 2021-01-22
1282 Pancreatic cancer prognosis is predicted by a novel ATAC-array technology for assessing chromatin accessibility
Dhara, S.; Chhangawala, S.; Chintalapudi, H.; Askan, G.; Aveson, V.; Massa, A. L.; Zhang, L.; Makohon-Moore, A. P.; Lecomte, N.; Melchor, J. P.; Bermeo, J.; Cardenas, A.; Sinha, S.; Glassman, D.; Nicolle, R.; Moffitt, R.; Yu, K.; Leppanen, S.; Laderman, S.; Curry, B.; Gui, J.; Balachandran, V.; Iacobuzio-Donahue, C. A.; Chandwani, R.; Leslie, C. S.; Leach, S. D.
10.1101/2021.01.21.427604 — cancer biology — Posted on 2021-01-22
1284 Measuring gas vesicle dimensions by electron microscopy
Dutka, P.; Malounda, D.; Metskas, L. A.; Chen, S.; Hurt, R. C.; Lu, G. J.; Jensen, G. J.; Shapiro, M. G.
10.1101/2021.01.22.427725 — biochemistry — Posted on 2021-01-22
1285 Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation
Lamers, M. M.; Mykytyn, A. Z.; Breugem, T. I.; Wang, Y.; Wu, D. C.; Riesebosch, S.; van den Doel, P. B.; Schipper, D.; Bestebroer, T.; Wu, N. C.; Haagmans, B. L.
10.1101/2021.01.22.427802 — microbiology — Posted on 2021-01-22
1286 Filamentation in Candida albicans is modulated by adaptive translation of farnesol signalling genes
Oliveira, C.; Guimaraes, A. R.; Correia, I.; Sousa, I.; Poim, A.; Rocha, S.; Moura, G. R.; Santos, M.; Bezerra, A. R.
10.1101/2021.01.20.427544 — microbiology — Posted on 2021-01-22
1287 Bispecific antibody prevents SARS-CoV-2 escape and protects mice from disease
De Gasparo, R.; Pedotti, M.; Simonelli, L.; Nickl, P.; Muecksch, F.; Lorenzi, J. C. C.; Mazzola, F.; Magri, D.; Michalcikova, T.; Haviernik, J.; Honig, V.; Cassaniti, I.; Percivalle, E.; Mrazkova, B.; Polakova, N.; Fortova, A.; Tureckova, J.; Iatsiuk, V.; Di Girolamo, S.; Palus, M.; Zudova, D.; Bednar, P.; Bukova, I.; Bianchini, F.; Mehn, D.; Nencka, R.; Strakova, P.; Pavlis, O.; Rozman, J.; Gioria, S.; Sammartino, J. C.; Giardina, F.; Gaiarsa, S.; Hammarström, Q. P.; Barnes, C. O.; Piralla, A.; Bjorkman, P. J.; Baldanti, F.; Calzolai, L.; Nussenzweig, M. C.; Bieniasz, P. D.; Hatziioannou, T.
10.1101/2021.01.22.427567 — immunology — Posted on 2021-01-22
1289 Queuine, a bacterial derived hypermodified nucleobase, shows protection in in vitro models of neurodegeneration
Richard, P.; Maniere, X.; Kozlowski, L.; Guillorit, H.; Garnier, P.; Danchin, A.; McKnight, N. C.
10.1101/2021.01.20.427538 — neuroscience — Posted on 2021-01-22
1291 A Simple Ultrafast Multicolor Immunolabelling and Clearing Approach for Whole-Organ and Large Tissue 3D Imaging
Biswas, L.; Chen, J.; De Angelis, J.; Chatzis, A.; Nanchahal, J.; Dustin, M.; Ramasamy, S.; Kusumbe, A.
10.1101/2021.01.20.427385 — physiology — Posted on 2021-01-22
1292 Human embryonic stem cell-derived cardiomyocytes express SARS-CoV-2 host entry proteins: screen to identify inhibitors of infection
Williams, T. L.; Colzani, M. T.; Macrae, R. G.; Robinson, E. L.; Bloor, S.; Greenwood, E. J.; Zhan, J. R.; Strachan, G.; Kuc, R. E.; Nyimanu, D.; Maguire, J. J.; Lehner, P. J.; Sinha, S.; Davenport, A. P.
10.1101/2021.01.22.427737 — pharmacology and toxicology — Posted on 2021-01-22
1293 DINC-COVID: A webserver for ensemble docking with flexible SARS-CoV-2 proteins
Hall-Swan, S.; Antunes, D. A.; Devaurs, D.; Rigo, M. M.; Kavraki, L. E.; Zanatta, G.
10.1101/2021.01.21.427315 — bioinformatics — Posted on 2021-01-22
1294 Insights from Genomes and Genetic Epidemiology of SARS-CoV-2 isolates from the state of Andhra Pradesh
Rani, P. R.; Imran, M.; Lakshmi, J. V.; Jolly, B.; Afsar, S.; Jain, A.; Divakar, M. K.; Suresh, P.; Sharma, D.; Rajesh, N.; Bhoyar, R. C.; Ankaiah, D.; Kumari, S. S.; Ranjan, G.; Lavanya, V. A.; Rophina, M.; Umadevi, S.; Sehgal, P.; Devi, A. R.; Surekha, A.; Chandra, P.; Hymavathy, R.; Vanaja, P. R.; Scaria, V.; Sivasubbu, S.
10.1101/2021.01.22.427775 — genomics — Posted on 2021-01-22
1295 The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus
Wells, H. L.; Letko, M. C.; Lasso, G.; Ssebide, B.; Nziza, J.; Byarugaba, D. K.; Navarrete-Macias, I.; Liang, E.; Cranfield, M.; Han, B. A.; Tingley, M. W.; Diuk-Wasser, M.; Goldstein, T.; Kreuder Johnson, C.; Mazet, J.; Chandran, K.; Munster, V.; Gilardi, K.; Anthony, S. J.
10.1101/2020.07.07.190546 — evolutionary biology — Posted on 2021-01-22
1296 Genomic Mutations and Changes in Protein Secondary Structure and Solvent Accessibility of SARS-CoV-2 (COVID-19 Virus)
Nguyen, T. T.; Pathirana, P. N.; Nguyen, T.; Nguyen, Q. V. H.; Bhatti, A.; Nguyen, D. C.; Nguyen, D. T.; Nguyen, N. D.; Creighton, D.; Abdelrazek, M.
10.1101/2020.07.10.171769 — bioinformatics — Posted on 2021-01-22
1298 A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process
Noske, G.; Nakamura, A.; Gawriljuk, V.; Fernandes, R.; Lima, G.; Rosa, H.; Pereira, H.; Zeri, A.; Nascimento, A.; Freire, M.; Oliva, G.; de Godoy, A. S.
10.1101/2020.12.23.424149 — biochemistry — Posted on 2021-01-22
1299 Temporal evolution and adaptation of SARS-COV 2 codon usage
Dilucca, M.; Forcelloni, S.; Giansanti, A.; Georgakilas, A.; Pavlopoulou, A.; Posani, E.
10.1101/2020.05.29.123976 — genomics — Posted on 2021-01-22
1301 TXN, a Xanthohumol Derivative, Significantly Attenuates High-Fat Diet Induced Hepatic Steatosis In Vivo by Antagonizing PPARγ
Zhang, Y.; Bobe, G.; Miranda, C. L.; Lowry, M. B.; Hsu, V. L.; Löhr, C. V.; Wong, C. P.; Jump, D. B.; Robinson, M. M.; Sharpton, T. J.; Maier, C. S.; Stevens, J. F.; Gombart, A. F.
10.1101/2021.01.11.426043 — molecular biology — Posted on 2021-01-22
1303 Sharpened and mechanically robust carbon fiber electrode arrays for neural interfacing
Welle, E. J.; Woods, J. E.; Jiman, A. A.; Richie, J. M.; Bottorff, E. C.; Ouyang, Z.; Seymour, J. P.; Patel, P. R.; Bruns, T. M.; Chestek, C. A.
10.1101/2021.01.21.427697 — bioengineering — Posted on 2021-01-22
1305 A new method for determining ribosomal DNA copy number shows differences between Saccharomyces cerevisiae populations
Sharma, D.; Hermann-Le Denmat, S.; Matzke, N. J.; Hannan, K.; Hannan, R. D.; O'Sullivan, J. M.; Ganley, A. R. D.
10.1101/2021.01.21.427686 — genomics — Posted on 2021-01-22
1306 Human-genome gut-microbiome interaction in Parkinson's disease
Wallen, Z. D.; Stone, W. J.; Factor, S. A.; Molho, E.; Zabetian, C. P.; Standaert, D. G.; Payami, H.
10.1101/2021.01.21.427679 — genetics — Posted on 2021-01-22
1308 A chromosomal inversion drives evolution of multiple adaptive traits in deer mice
Hager, E. R.; Harringmeyer, O. S.; Wooldridge, T. B.; Theingi, S.; Gable, J. T.; McFadden, S.; Neugeboren, B.; Turner, K. M.; Hoekstra, H. E.
10.1101/2021.01.21.427490 — evolutionary biology — Posted on 2021-01-22
1310 A Single Cell Atlas of Lung Development
Negretti, N. M.; Plosa, E. J.; Benjamin, J. T.; Schuler, B. A.; Habermann, A. C.; Jetter, C. S.; Taylor, C. J.; Gulleman, P.; Nichols, D.; Matlock, B. K.; Guttentag, S. H.; Blackwell, T. S.; Banovich, N. E.; Kropski, J. A.; Sucre, J. M.
10.1101/2021.01.21.427641 — developmental biology — Posted on 2021-01-22
1312 IGFBP2 protects against pulmonary fibrosis through inhibiting P21-mediated senescence
Chiahsuan, C.; Lee, J.; Ravichandran, R.; Fleming, T.; Wheatcroft, S.; Kearney, M.; Bremner, R.; Mohanakumar, T.; Flint, D. J.; Sureshbabu, A.
10.1101/2021.01.21.427684 — molecular biology — Posted on 2021-01-22
1314 Prophage-encoded hotspots of bacterial immune systems
Rousset, F.; Dowding, J.; Bernheim, A.; Rocha, E.; Bikard, D.
10.1101/2021.01.21.427644 — microbiology — Posted on 2021-01-22
1315 Extracellular vesicles regulate yeast growth, biofilm formation, and yeast-to-hypha differentiation in Candida albicans
Honorato, L.; Demetrio, J. F.; Ellis, C. C.; Piffer, A. C.; Pereira, Y.; Frases, S.; Araujo, G.; Pontes, B.; Mendes, M. T.; Pereira, M. D.; Guimaraes, A. J.; da Silva, N. M.; Vargas, G.; Joffe, L.; Del Poeta, M.; Nosanchuk, J. D.; Zamith Miranda, D.; Reis, F.; Rodrigues, M. L.; Martins, S.; Alves, L. R.; Almeida, I. C.; Nimrichter, L.
10.1101/2021.01.21.427696 — microbiology — Posted on 2021-01-22
1324 iGEM comes of age: trends in its research output.
Jainarayanan, A. K.; Galanis, A.; Nakara, A. M.; Kundlatsch, G. E.; Rubio Sanchez, R. M.
10.1101/2021.01.21.424716 — scientific communication and education — Posted on 2021-01-22
1325 Genetically Engineered Strains for Combinatorial Cardiovascular Optobiology
Lee, F. K.; Lee, J. C.; Shui, B.; Reining, S.; Jibilian, M.; Small, D. M.; Jones, J. S.; Allan-Rahill, N. H.; Lamont, M. R.; Rizzo, M. A.; Tajada, S.; Navedo, M. F.; Santana, L. F.; Nishimura, N.; Kotlikoff, M. I.
10.1101/2021.01.21.427692 — physiology — Posted on 2021-01-22
1326 HLA-G gene editing: a novel therapeutic alternative in cancer immunotherapy
Palma, M. B.; Tronik-Le Roux, D.; Amin, G.; Castaneda, S.; Mobbs, A. M.; Scarafia, M. A.; La Greca, A.; Daouya, M.; Poras, I.; Inda, A. M.; Moro, L. N.; Carosella, E. D.; Garcia, M. N.; Miriuka, S. G.
10.1101/2021.01.21.427294 — cancer biology — Posted on 2021-01-22
1327 4D chromosome reconstruction elucidates the spatial reorganization of the mammalian X-chromosome
Lappala, A.; Wang, C.-Y.; Kriz, A.; Michalk, H.; Tan, K.; Lee, J.; Sanbonmatsu, K.
10.1101/2021.01.21.427652 — biophysics — Posted on 2021-01-22
1329 Indian genetic heritage in Southeast Asian populations
Changmai, P.; Jaisamut, K.; Kampuansai, J.; Kutanan, W.; Altınısık, N. E.; Flegontova, O.; Inta, A.; Yüncü, E.; Boonthai, W.; Pamjav, H.; Reich, D.; Flegontov, P.
10.1101/2021.01.21.427591 — genetics — Posted on 2021-01-22
1330 Simulation of sugar kelp (Saccharina latissima) breeding guided by practices to prioritize accelerated research gains
Huang, M.; Robbins, K.; Li, Y.; Umanzor, S.; Marty-Rivera, M.; Bailey, D.; Yarish, C.; Lindell, S.; Janninck, J.-L.
10.1101/2021.01.21.427651 — genetics — Posted on 2021-01-22
1336 Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world smallest mammalian divers
He, K.; Eastman, T. G.; Czolacz, H.; Li, S.; Shinohara, A.; Kawada, S.-i.; Springer, M.; Berenbrink, M.; Campbell, K. L.
10.1101/2021.01.14.426706 — evolutionary biology — Posted on 2021-01-22
1339 A conserved role of Parkinson-associated DJ-1 metabolites in sperm motility, mitosis, and embryonic development
Bour, S.; Dening, Y.; Balbach, M.; Poser, I.; Ramirez Alvarez, I.; den Haan, H.; Kluge, C.; Naumann, R.; Oertel, R.; Alba-Alejandre, I.; Accardi, D.; Stief, C. G.; Dieterich, M.; Falkai, P.; Boeckmann, R. A.; Perez-Sanchez, H.; Hyman, A. A.; Trottmann, M.; Pan-Montojo, F. J.
10.1101/2021.01.16.426934 — developmental biology — Posted on 2021-01-22
1341 Intergenerational transmission of the patterns of functional and structural brain networks
Takagi, Y.; Okada, N.; Ando, S.; Yahata, N.; Morita, K.; Koshiyama, D.; Kawakami, S.; Sawada, K.; Koike, S.; Endo, K.; Yamasaki, S.; Nishida, A.; Kasai, K.; Tanaka, S. C.
10.1101/2020.03.06.981068 — neuroscience — Posted on 2021-01-22
1344 Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems
Hill, V.; Akarsu, H.; Barbarroja, R. S.; Cippa, V. L.; Heller, M.; Falquet, L.; Heller, M.; Labroussaa, F.; Jores, J.; Stoffel, M. H.
10.1101/2021.01.21.427616 — microbiology — Posted on 2021-01-21
1346 A study of Mutation in ATP7B gene and its correlation with clinical phenotype and radiological features in Wilson Disease patients
Chaudhuri, J.; Biswas, S.; Gangopadhyay, G.; Biswas, T.; Datta, J.; Biswas, A.; Datta, A.; Mukherjee, A.; Hazra, A.; Datta, A. K.
10.1101/2021.01.21.427561 — neuroscience — Posted on 2021-01-21
1349 Legacy of draught cattle breeds of South India: Insights into population structure, genetic admixture and maternal origin
Manomohan, V.; Saravanan, R.; Pichler, R.; Murali, N.; Sivakumar, K.; Sudhakar, K.; Nachiappan, R. K.; Periasamy, K.
10.1101/2021.01.21.427560 — genetics — Posted on 2021-01-21
1352 Genome-wide discovery of lupus genetic risk variant allelic regulatory activity
Lu, X.; Chen, X.; Forney, C.; Donmez, O.; Miller, D.; Parameswaran, S.; Hong, T.; Huang, Y.; Pujato, M.; Cazares, T.; Miraldi, E. R.; Ray, J. P.; de Boer, C. G.; Harley, J. B.; Weirauch, M. T.; Kottyan, L. C.
10.1101/2020.01.20.906701 — genomics — Posted on 2021-01-21
1354 SpecSeg: cross spectral power-based segmentation of neurons and neurites in chronic calcium imaging datasets
de Kraker, L.; Seignette, K.; Thamizharasu, P.; van den Boom, B. J.; Ferreira Pica, I.; Willuhn, I.; Levelt, C. N.; van der Togt, C.
10.1101/2020.10.20.345371 — neuroscience — Posted on 2021-01-21
1355 Single-molecule FRET dynamics of molecular motors in an ABEL Trap
Dienerowitz, M.; Howard, J. A. L.; Quinn, S. D.; Dienerowitz, F.; Leake, M. C.
10.1101/2020.09.21.306704 — biophysics — Posted on 2021-01-21
1360 Association of NQO1 C609T (Pro187Ser) with risk of Oral Submucous Fibrosis in Eastern Indian population
Mukherjee, S.; Mohanty, S.; Katarkar, A.; Dhariwal, R.; Mahato, B.; Ray, J. G.; Chaudhuri, K.
10.1101/046052 — genetics — Posted on 2021-01-21
1361 Human Pre-Implantation Embryos Are Permissive to SARS-CoV-2 Entry
Montano, M.; Victor, A. R.; Griffin, D. K.; Duong, T.; Bolduc, N.; Farmer, A.; Garg, V.; Hadjantonakis, A.-K.; Barnes, F. L.; Zouves, C. G.; Greene, W. C.; Viotti, M.
10.1101/2021.01.21.427501 — developmental biology — Posted on 2021-01-21
1364 Tristetraprolin prevents gastric metaplasia in mice by suppressing pathogenic inflammation
Busada, J. T.; Kadka, S.; Peterson, K. N.; Stumpo, D. J.; Zhou, L.; Cidlowski, J. A.; Blackshear, P. J.
10.1101/2021.01.21.427435 — immunology — Posted on 2021-01-21
1368 Duchenne Muscular Dystrophy Cell Culture Models Created By CRISPR/Cas9 Gene Editing And Their Application To Drug Screening
Soblechero-Martin, P.; Albiasu-Arteta, E.; Anton-Martinez, A.; de la Puente-Ovejero, L.; Garcia-Jimenez, I.; Gonzalez-Iglesias, G.; Larranaga-Aiestaran, I.; Lopez-Martinez, A.; Poyatos-Garcia, J.; Ruiz-Del-Yerro, E.; Gonzalez, F.; Arechavala-Gomeza, V.
10.1101/2020.02.24.962316 — neuroscience — Posted on 2021-01-21
1372 A novel Wnt/beta-catenin signaling driven adipocyte population that is required for beiging
Liu, Z.; Chen, T.; Zhang, S.; Yang, T.; Gong, Y.; deng, H.-W.; Bai, D.; Tian, W.; Chen, Y.
10.1101/2021.01.14.426702 — physiology — Posted on 2021-01-21
1373 In vivo analysis of the contribution of proprotein convertases to the processing of FGF23
Al Rifai, O.; Susan-Resiga, D.; Essalmani, R.; Creemers, J.; Seidah, N. G.; Ferron, M.
10.1101/2021.01.15.426882 — physiology — Posted on 2021-01-21
1379 Modulation of implanted aortic scaffold- involvement of ECM and immune proteins
Banerjee, D.; Nayakawde, N. B.; Antony, D.; Deshmukh, M.; Ghosh, S.; Sihlbom, C.; Ul Haq, U.; Olausson, M.
10.1101/2020.11.21.392654 — bioengineering — Posted on 2021-01-21
1382 Restoring fertility in yeast hybrids: breeding and quantitative genetics of beneficial traits
Naseeb, S.; Visinoni, F.; Hu, Y.; Hinks Roberts, A. J.; Maslowska, A.; Walsh, T.; Smart, K. A.; Louis, E. J.; Delneri, D.
10.1101/2021.01.21.427634 — genetics — Posted on 2021-01-21
1384 Evolutionary and ecological processes influencing chemical defense variation in an aposematic and mimetic Heliconius butterfly
Mattila, A. L. K.; Jiggins, C. D.; Opedal, O. H.; Montejo-Kovacevich, G.; de Castro, E.; McMillan, W. O.; Bacquet, C.; Saastamoinen, M.
10.1101/2020.01.14.905950 — evolutionary biology — Posted on 2021-01-21
1387 SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes
Yildirim, A.; Mozaffari-Jovin, S.; Wallisch, A.-K.; Ries, J.; Ludwig, S.; Urlaub, H.; Luehrmann, R.; Wolfrum, U.
10.1101/2020.11.11.378448 — cell biology — Posted on 2021-01-21
1388 Blocking the Rac1-TRPC5 pathway protects human podocytes
Zhou, Y.; Kim, C.; Pablo, J. L. B.; Zhang, F.; Jung, J. Y.; Xiao, L.; Bazua, S.; Emani, M.; Hopkins, C.; Weins, A.; Greka, A.
10.1101/2020.08.28.272344 — cell biology — Posted on 2021-01-21
1389 Quantitative Mapping of Human Hair Graying and Reversal in Relation to Life Stress
Rosenberg, A.; Rausser, S.; Ren, J.; Mosharov, E.; Sturm, G. M.; Ogden, R. T.; Patel, P.; Soni, R. K.; Lacefield, C.; Tobin, D. J.; Paus, R.; Picard, M.
10.1101/2020.05.18.101964 — cell biology — Posted on 2021-01-21
1390 Ketogenesis Impact on Liver Metabolism Revealed by Proteomics of Lysine β-hydroxybutyrylation
Koronowski, K. B.; Greco, C. M.; Huang, H.; Kim, J.-K.; Fribourgh, J.; Crosby, P.; Partch, C. L.; Qiao, F.; Zhao, Y.; Sassone-Corsi, P.
10.1101/2021.01.21.427645 — molecular biology — Posted on 2021-01-21
1391 Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
Teano, G.; Concia, L.; Carron, L.; Wolff, L.; Adamusova, K.; Fojtova, M.; Bourge, M.; Kramdi, A.; Colot, V.; Grossniklaus, U.; Bowler, C.; Baroux, C.; Carbone, A.; Probst, A. V.; Prochazkova Schrumpfova, P.; Fajkus, J.; Amiard, S.; Grob, S.; Bourbousse, C.; Barneche, F.
10.1101/2020.11.28.402172 — molecular biology — Posted on 2021-01-21
1392 Survey of peridomestic mammal susceptibility to SARS-CoV-2 infection
Bosco-Lauth, A.; Root, J. J.; Porter, S.; Walker, A.; Guilbert, L.; Hawvermale, D.; Pepper, A.; Maison, R.; Hartwig, A.; Gordy, P.; Bielefeldt-Ohmann, H.; Bowen, R. A.
10.1101/2021.01.21.427629 — microbiology — Posted on 2021-01-21
1397 Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels
Stevens, S.; Longley, C. M.; Ogawa, Y.; Teliska, L.; Arumanayagam, A.; Nair, S.; Oses-Prieto, J. A.; Burlingame, A. L.; Cykowski, M.; Xue, M.; Rasband, M. N.
10.1101/2021.01.21.427626 — neuroscience — Posted on 2021-01-21
1399 Activity in perirhinal and entorhinal cortex predicts observer-specific perceived visual similarities between objects
Ferko, K. M.; Blumenthal, A.; Martin, C. B.; Proklova, D.; Saksida, L. M.; Bussey, T. J.; Khan, A. R.; Köhler, S.
10.1101/2021.01.21.427602 — neuroscience — Posted on 2021-01-21
1400 Functionnectome: a framework to analyse the contribution of brain circuits to fMRI
Nozais, V.; Forkel, S. J.; Foulon, C. J.; Petit, L.; Thiebaut de Schotten, M.
10.1101/2021.01.06.425574 — neuroscience — Posted on 2021-01-21
1401 Nodal GABA facilitates axon spike transmission in the spinal cord.
Hari, K.; Lucas-Osma, A. M.; Metz, K.; Lin, S.; Pardell, N.; Roszko, D.; Black, S.; Minarik, A.; Singla, R.; Stephens, M. J.; Fouad, K.; Jones, K. E.; Gorassini, M. A.; Fenrich, K. K.; Li, Y.; Bennett, D. J.
10.1101/2021.01.20.427494 — neuroscience — Posted on 2021-01-21
1402 Striatal Direct Pathway Targets Npas1+ Pallidal Neurons
Cui, Q.; Du, X.; Chang, I.; Pamukcu, A.; Lilascharoen, V.; Berceau, B.; Garcia, D.; Hong, D.; Chon, U.; Narayanan, A.; Kim, Y.; Lim, B.; Chan, S.
10.1101/2020.09.02.273615 — neuroscience — Posted on 2021-01-21
1405 Connectome: computation and visualization of cell-cell signaling topologies in single-cell systems data
Raredon, M. S. B.; Yang, J.; Garritano, J.; Wang, M.; Kushnir, D.; Schupp, J. C.; Adams, T. S.; Greaney, A. M.; Leiby, K. L.; Kaminski, N.; Kluger, Y.; Levchenko, A.; Niklason, L. E.
10.1101/2021.01.21.427529 — systems biology — Posted on 2021-01-21
1411 GenNet framework: interpretable neural networks for phenotype prediction
van Hilten, A.; Kushner, S. A.; Kayser, M.; Ikram, M. A.; Adams, H.; Klaver, C.; Niessen, W. J.; Roshchupkin, G. V.
10.1101/2020.06.19.159152 — bioinformatics — Posted on 2021-01-21
1417 AdipoAtlas: A Reference Lipidome for Human White Adipose Tissue
Lange, M.; Angelidou, G.; Ni, Z.; Criscuolo, A.; Schiller, J.; Blueher, M.; Fedorova, M.
10.1101/2021.01.20.427444 — biochemistry — Posted on 2021-01-21
1418 Profiling of open chromatin in developing pig (Sus scrofa) muscle to identify regulatory regions
Salavati, M.; Woolley, S. A.; Cortes Araya, Y.; Halstead, M. M.; Stenhouse, C.; Johnsson, M.; Ashworth, C. J.; Archibald, A. L.; Donadeu, F. X.; Hassan, M. A.; Clark, E. L.
10.1101/2021.01.21.426812 — genomics — Posted on 2021-01-21
1419 Species ecology explains the various spatial components of genetic diversity in tropical reef fishes
Donati, G. F. A.; Zemp, N.; Manel, S.; Poirier, M.; Claverie, T.; Ferraton, F.; Gaboriau, T.; Govinden, R.; Hagen, O.; Ibrahim, S.; Mouillot, D.; Leblond, J.; Pagu, J.; Velez, L.; Zareer, I.; Ziyad, A.; Leprieur, F.; Albouy, C.; Pellissier, L.
10.1101/2021.01.21.427590 — genetics — Posted on 2021-01-21
1420 miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to affect muscle contractility upon proteotoxic challenge during ageing
Schiffer, I.; Gerisch, B.; Kawamura, K.; Laboy, R.; Hewitt, J.; Denzel, M. S.; Mori, M. A.; Vanapalli, S.; Shen, Y.; Symmons, O.; Antebi, A.
10.1101/2021.01.21.427623 — genetics — Posted on 2021-01-21
1422 Coupled myovascular expansion directs growth and regeneration of the neonatal mouse heart
DeBenedittis, P.; Karpurapu, A.; Henry, A.; Thomas, M. C.; McCord, T.; Brezitski, K.; Prasad, A.; Kobayashi, Y.; Shah, S.; Kontos, C.; TATA, P. R.; Lumbers, R. T.; Karra, R.
10.1101/2021.01.20.425322 — developmental biology — Posted on 2021-01-21
1423 Adipocyte lipolysis abrogates skin fibrosis in a Wnt/DPP4-dependent manner
Jussila, A. R.; Caves, E.; Zhang, B.; Kirti, S.; Steele, M.; Lei, V.; Hamburg-Shields, E.; Lydon, J.; Ying, Y.; Lafyatis, R.; Rajagopalan, S.; Horsley, V.; Atit, R. P.
10.1101/2021.01.21.427497 — cell biology — Posted on 2021-01-21
1425 Nef dimerization defect abrogates HIV viremia and associated immune dysregulation in the Bone Marrow-Liver-Thymus-Spleen (BLTS) humanized mouse model
Biradar, S.; Agarwal, Y.; Das, A.; Shu, S. T.; Samal, J.; Ho, S.; Beatty, C.; Castronova, I.; Mailliard, R. B.; Smithgall, T. E.; Bility, M. T.
10.1101/2021.01.21.427631 — immunology — Posted on 2021-01-21
1426 Microglial NKCC1 shapes microglial phenotype, cerebral inflammatory responses and brain injury
Toth, K.; Lenart, N.; Szabadits, E.; Posfai, B.; Fekete, R.; Cserep, C.; Alatshan, A.; Benkö, S.; Hübner, C. A.; Kaila, K.; Környei, Z.; Denes, A.
10.1101/2021.01.21.427597 — neuroscience — Posted on 2021-01-21
1427 The effects of long-term exercise training on the neural control of walking
Yaserifar, M.; Mohammadi, Z. F.; Hosseininejad, S. E.; Afrakoti, I. E. P.; Meijer, K.; Boonstra, T. W.
10.1101/2021.01.21.427603 — neuroscience — Posted on 2021-01-21
1431 4D imaging of soft matter in liquid water
Battaglia, G.; Marchello, G.; De Pace, C.; Acosta Gutierrez, S.; Lopez Vasquez, C.; Wilkinson, N.; Gervasio, F. L.; Ruiz Perez, L.
10.1101/2021.01.21.427613 — biophysics — Posted on 2021-01-21
1432 Design of Specific Primer Sets for the Detection of B.1.1.7, B.1.351 and P.1 SARS-CoV-2 Variants using Deep Learning
Lopez-Rincon, A.; Perez-Romero, C.; Tonda, A.; Mendoza-Maldonado, L.; Claassen, E.; Garssen, J.; Kraneveld, A. D.
10.1101/2021.01.20.427043 — bioinformatics — Posted on 2021-01-21
1435 Single-cell deconvolution of 3,000 post-mortem brain samples for eQTL and GWAS dissection in mental disorders
Park, Y. P.; He, L.; Davila-Velderrain, J.; Hou, L.; Mohammadi, S.; Mathys, H.; Peng, Z.; Bennett, D.; Tsai, L.-H.; Kellis, M.
10.1101/2021.01.21.426000 — genomics — Posted on 2021-01-21
1440 Matriptase generates a tissue damage response via promoting Gq signalling, leading to RSK and DUOX activation
Ma, J.; Scott, C. A.; Ho, Y. N.; Marsay, K. S.; Zhang, C.; Teow, C. K. J.; Ng, S. S.; Zhang, W.; Tergaonkar, V.; Partridge, L. J.; Roy, S.; Amaya, E.; Carney, T. J.
10.1101/2021.01.21.427549 — cell biology — Posted on 2021-01-21
1441 A zebrafish reporter line reveals immune and neuronal expression of endogenous retrovirus.
Hamilton, N.; Clarke, A.; Isles, H.; Carson, E. G.; Levraud, J.-P.; Renshaw, S. A.
10.1101/2021.01.21.427598 — cell biology — Posted on 2021-01-21
1442 Piezo1 and BKCa channels in human atrial fibroblasts: interplay and remodelling in atrial fibrillation
Jakob, D.; Klesen, A.; Allegrini, B.; Darkow, E.; Aria, D.; Emig, R.; Chica, A. S.; Rog-Zielinska, E. A.; Guth, T.; Beyersdorf, F.; Kari, F. A.; Proksch, S.; Hatem, S. N.; Karck, M.; Kunzel, S. R.; Guizouarn, H.; Schmidt, C.; Kohl, P.; Ravens, U.; Peyronnet, R.
10.1101/2021.01.21.427388 — molecular biology — Posted on 2021-01-21
1443 The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length
Vinayak Vernekar, D.; Reginato, G.; Adam, C.; Ranjha, L.; Dingli, F.; Marsolier, M.-C.; Loew, D.; Guerois, R.; llorente, b.; Cejka, P.; Borde, V.
10.1101/2021.01.21.427607 — molecular biology — Posted on 2021-01-21
1445 High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity.
Choi, R.; Zhou, M.; Shek, R.; Wilson, J. W.; Tillery, L.; Craig, J. K.; Salukhe, I. A.; Hickson, S. E.; Kumar, N.; James, R. M.; Buchko, G. W.; Wu, R.; Huff, S.; Nguyen, T.-T.; Hurst, B. L.; Cherry, S.; Barrett, L. K.; Van Voorhis, W. C.
10.1101/2021.01.21.427657 — microbiology — Posted on 2021-01-21
1446 In vitro infection of human lung tissue with SARS-CoV-2: Heterogeneity in host defense and therapeutic response
Schaller, M. A.; Sharma, Y.; Dupee, Z.; Nguyen, D. T.; Uruena, J. M.; Smolcheck, R. A.; Loeb, J. C.; Machuca, T. N.; Lednicky, J. A.; Odde, D.; Campbell, R. F.; Sawyer, W. G.; Mehrad, B.
10.1101/2021.01.20.427541 — microbiology — Posted on 2021-01-21
1449 T cell circuits that sense antigen density with an ultrasensitive threshold
Hernandez-Lopez, R. A.; Yu, W.; Cabral, K. A.; Creasey, O. A.; Lopez Pamino, M. d. P.; Tonai, Y.; De Guzman, A.; Makela, A.; Saksela, K.; Gartner, Z. J.; Lim, W.
10.1101/2021.01.21.427654 — synthetic biology — Posted on 2021-01-21
1452 Landscape of glioblastoma niches reveals the prognostic effects of tumor-infiltrating cells
Xiao, Z.; Zhang, W.; Li, G.; Li, W.; Li, L.; Sun, T.; He, Y.; Liu, G.; Wang, L.; Han, X.; Wen, H.; Liu, Y.; Chen, Y.; Wang, H.; Li, J.; Fan, Y.; Zhang, J.
10.1101/2021.01.20.427411 — cancer biology — Posted on 2021-01-21
1455 Population dynamics of the primary malaria vector Nyssorhynchus darlingi in a high transmission setting dominated by fish farming in western Amazonian Brazil
Rufalco-Moutinho, P.; Kadri, S. M.; Alonso, D. P.; Moreno, M.; Carrasco-Escobar, G.; Prussing, C.; Gamboa, D.; Vinetz, J. M.; Mureb Sallum, M. A.; Conn, J. E.; Ribolla, P. E. M.
10.1101/2021.01.20.427434 — ecology — Posted on 2021-01-21
1456 A critical role of AREG for bleomycin-induced skin fibrosis
Zhang, M. Y.; Fang, S.; Gao, H.; Zhang, X.; Gu, D.; Liu, Y.; Wan, J.; Xie, J.
10.1101/2021.01.20.427509 — developmental biology — Posted on 2021-01-21
1457 Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
Vilaplana-Lopera, N.; Almaghrabi, R.; Papatzikas, G.; Gonzalez, E.; Cunningham, A.; Erdem, A.; Schnuetgen, F.; Raghavan, M.; Potluri, S.; Cazier, J.-B.; Schuringa, J. J.; Reed, M. A.; Gunther, U. L.; Garcia, P.
10.1101/2021.01.21.427406 — cell biology — Posted on 2021-01-21
1458 Targeting fibrosis in the Duchenne Muscular Dystrophy mice model: an uphill battle
Theret, M.; Low, M.; Rempel, L.; Li, F. f.; Tung, L. W.; Contreras, O.; Chang, C. K.; Wu, A.; Soliman, H.; Rossi, F. M. V.
10.1101/2021.01.20.427485 — cell biology — Posted on 2021-01-21
1462 Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro
Mossink, B.; Verboven, A. H. A.; van Hugte, E. J. H.; Klein Gunnewiek, T. M.; Parodi, G.; Linda, K.; Schoenmaker, C.; Kleefstra, T.; Kozicz, T.; van Bokhoven, H.; Schubert, D.; Nadif Kasri, N.; Frega, M.
10.1101/2021.01.20.427439 — neuroscience — Posted on 2021-01-21
1465 Synaptic inhibition in the lateral habenula shapes reward anticipation
Lalive, A. L.; Congiu, M.; Clerke, J. A.; Tchenio, A.; Ge, Y.; Mameli, M.
10.1101/2021.01.21.427572 — neuroscience — Posted on 2021-01-21
1468 The elephant retina examined across a range of ages
freed, j.; Joyce, S.; Whalley, R.; Purse, E.; Ingram, T. L.; Yon, L.; Chakrabarti, L.
10.1101/2021.01.20.427452 — zoology — Posted on 2021-01-21
1470 Molecular determinants underlying DS2 activity at δ-containing GABAA receptors
Falk-Petersen, C. B.; Rostrup, F.; Loffler, R.; Buchleithner, S.; Harpsoe, K.; Gloriam, D.; Frolund, B.; Wellendorph, P.
10.1101/2021.01.21.427670 — pharmacology and toxicology — Posted on 2021-01-21
1475 PASV: Automatic protein partitioning and validation using conserved residues
Moore, R. M.; Harrison, A. O.; Nasko, D. J.; Chopyk, J.; Cebeci, M.; Ferrell, B. D.; Polson, S. W.; Wommack, K. E.
10.1101/2021.01.20.427478 — bioinformatics — Posted on 2021-01-21
1476 Deconvolving clinically relevant cellular immune crosstalk from bulk gene expression using CODEFACS and LIRICS
Wang, K.; Patkar, S.; Lee, J. S.; Gertz, E. M.; Robinson, W.; Schischlik, F.; Crawford, D.; Schaffer, A. A.; Ruppin, E.
10.1101/2021.01.20.427515 — bioinformatics — Posted on 2021-01-21
1483 Design considerations of a wearable electronic-skin for mental health and wellness: balancing biosignals and human factors
Khan, Y.; Mauriello, M. L.; Nowruzi, P.; Motani, A.; Hon, G.; Vitale, N.; Li, J.; Kim, J.; Foudeh, A.; Duvio, D.; Shols, E.; Chesnut, M.; Landay, J.; Liphardt, J.; Williams, L.; Sudheimer, K. D.; Murmann, B.; Bao, Z.; Paredes, P. E.
10.1101/2021.01.20.427496 — bioengineering — Posted on 2021-01-21
1484 A rational blueprint for the design of chemically-controlled protein switches
Shui, S.; Gainza, P.; Scheller, L.; Yang, C.; Kurumida, Y.; Georgeon, S.; Rosset, S.; Correia, B.
10.1101/2021.01.21.427547 — biochemistry — Posted on 2021-01-21
1485 Adolescent social stress decrease of adult morphine-induced behavioral sensitization is dependent upon genetic background
Kamens, H.; Miller, C.; Caulfield, J.; Zeid, D.; Horton, W.; Silva, C.; Sebastian, A.; Albert, I.; Gould, T.; Fishbein, D.; Grigson, P. S.; Cavigelli, S.
10.1101/2021.01.20.427504 — animal behavior and cognition — Posted on 2021-01-21
1488 Optimising expression quantitative trait locus mapping workflows for single-cell studies
Cuomo, A. S.; Alvari, G.; Azodi, C. B.; single-cell eQTLGen consortium, ; McCarthy, D. J.; Bonder, M. J.
10.1101/2021.01.20.427401 — genetics — Posted on 2021-01-21
1490 An elongated COI fragment to discriminate botryllid species and as an improved ascidian DNA barcode
Salonna, M.; Gasparini, F.; Huchon, D.; Montesanto, F.; Haddas-Sasson, M.; Ekins, M.; McNamara, M.; Mastrototaro, F.; Gissi, C.
10.1101/2021.01.20.427448 — evolutionary biology — Posted on 2021-01-21
1496 Ocular elongation and retraction in foveated reptiles
Rasys, A. M.; Pau, S. H.; Irwin, K. E.; Luo, S.; Trainor, P. A.; Menke, D. B.; Lauderdale, J. D.
10.1101/2021.01.20.427408 — developmental biology — Posted on 2021-01-21
1499 γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release.
Hu, M. D.; Golovchenko, N. B.; Kelly, T. J.; Agos, J.; Zeglinski, M. R.; Bonder, E. M.; Granville, D. J.; Watson, A. J. M.; Edelblum, K. L.
10.1101/2021.01.20.427150 — immunology — Posted on 2021-01-21
1502 Simulating lesion-dependent functional recovery mechanisms
Sajid, N.; Holmes, E.; Hope, T.; Fountas, Z.; Price, C.; Friston, K.
10.1101/2021.01.20.427450 — neuroscience — Posted on 2021-01-21
1503 CloudBrain: Online neural computation in the cloud
Larsen, L. B.; Stagsted, R.; Strohmer, B.; Christensen, A. L.
10.1101/2021.01.21.427662 — neuroscience — Posted on 2021-01-21
1504 Increased ventromedial prefrontal cortex activity in adolescence benefits prosocial reinforcement learning
Westhoff, B.; Blankenstein, N. E.; Schreuders, E.; Crone, E. A.; Van Duijvenvoorde, A. C. K.
10.1101/2021.01.21.427660 — neuroscience — Posted on 2021-01-21
1510 Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury
Gusarova, G. A.; Das, S.; Islam, M. N.; Westphalen, K.; Jin, G.; Shmarakov, I. O.; Li, L.; Bhattacharya, S.; Bhattacharya, J.
10.1101/2021.01.20.427469 — physiology — Posted on 2021-01-21
1513 ImPartial: Partial Annotations for Cell Instance Segmentation
Martinez, N.; Sapiro, G.; Tannenbaum, A. R.; Hollmann, T. J.; Nadeem, S.
10.1101/2021.01.20.427458 — bioengineering — Posted on 2021-01-21
1514 Fine-scale changes in speed and altitude suggest protean movements in homing pigeon flights
Garde, B.; Wilson, R. P.; Lempidakis, E. L.; Borger, L.; Portugal, S. P.; Hedenstrom, A.; Dell'omo, G.; Quetting, M.; Wikelski, M.; Shepard, E. L.
10.1101/2021.01.20.427436 — animal behavior and cognition — Posted on 2021-01-21
1516 The pseudouridine synthase dyskerin binds to cytoplasmic H/ACA-box snoRNA retaining transcripts affecting nuclear hormone receptor dependence
Zacchini, F.; Venturi, G.; De Sanctis, V.; Bertorelli, R.; Ceccarelli, C.; Santini, D.; Taffurelli, M.; Penzo, M.; Trere, D.; Inga, A.; Dassi, E.; Montanaro, L.
10.1101/2021.01.21.427585 — molecular biology — Posted on 2021-01-21
1517 Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis through dye-functionalized lipid nanocarriers
Press, A. T.; Babic, P.; Hoffmann, B.; Mueller, T.; Foo, W.; Hauswald, W.; Benecke, J.; Beretta, M.; Cseresnyes, Z.; Hoeppner, S.; Nischang, I.; Coldewey, S. M.; Graeler, M. H.; Bauer, R.; Gonnert, F.; Gassler, N.; Wetzker, R.; Figge, M. T.; Schubert, U. S.; Bauer, M.
10.1101/2021.01.20.427305 — molecular biology — Posted on 2021-01-21
1518 DAP5 enables translation re-initiation on structured messenger RNAs
Weber, R.; Kleemann, L.; Hirschberg, I.; Chung, M.-Y.; Valkov, E.; Igreja, C.
10.1101/2021.01.21.427569 — molecular biology — Posted on 2021-01-21
1519 APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer
Isozaki, H.; Abbasi, A.; Nikpour, N.; Langenbucher, A.; Su, W.; Stanzione, M.; Frisco-Cabanos, H.; Siddiqui, F. M.; Phan, N.; Jalili, P.; Oh, S.; Timonina, D.; Bilton, S.; Gomez-Caraballo, M.; Archibald, H. L.; Nangia, V.; Dionne, K.; Riley, A.; Lawlor, M.; Banwait, M. K.; Cobb, R. G.; Zou, L.; Dyson, N. J.; Ott, C. J.; Benes, C.; Getz, G.; Chan, C.; Shaw, A. T.; Lin, J. J.; Sequist, L. V.; Piotrowska, Z.; Engelman, J. A.; Lee, J. J.-K.; Maruvka, Y.; Buisson, R.; Lawrence, M. S.; Hata, A. N.
10.1101/2021.01.20.426852 — cancer biology — Posted on 2021-01-21
1522 Gradual opening of Smc arms in prokaryotic condensin
Vazquez Nunez, R. J.; Polyhach, Y.; Soh, Y.-M.; Jeschke, G.; Gruber, S.
10.1101/2021.01.21.427566 — biochemistry — Posted on 2021-01-21
1523 Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway
Hannan, K. M.; Soo, P.; Wong, M. S.; Lee, J. K.; Hein, N.; Evers, M.; Wysoke, K. D.; Williams, T. D.; Montellese, C.; Smith, L.; Al-Obaidi, S. J.; Nunez-Villacis, L.; Poh, P.; Pavy, M.; He, J.-S.; Parsons, K. M.; Diesch, J.; Burgio, G.; Ferreira, R.; Feng, Z.-P.; Gould, C. M.; Madhamshettiwar, P. B.; Flygare, J.; Gonda, T. J.; Simpson, K. J.; Kutay, U.; Pearson, R. B.; Engel, C.; Watkins, N.; Hannan, R. D.; George, A. J.
10.1101/2021.01.21.427535 — cell biology — Posted on 2021-01-21
1524 Targeted sensors for glutamatergic neurotransmission
Hao, Y.; Toulme, E.; König, B.; Rosenmund, C.; Plested, A. J. R.
10.1101/2021.01.21.427382 — neuroscience — Posted on 2021-01-21
1530 Local jasmonic acid cues drive systemic acquired resistance signal generation
Sales, J. H.; Pabst, E.; Wenig, M.; Breitenbach, H. H.; Perez, G.; Knappe, C.; Hammerl, R.; Liu, J.; Rozhon, W.; Poppenberger, B.; Grill, E.; Dawid, C.; Vlot, C.
10.1101/2021.01.20.427489 — plant biology — Posted on 2021-01-21
1532 Whole-genome sequence analysis of mutations in rice plants regenerated from zygotes, mature embryos, and immature embryos
Ichikawa, M.; Kato, N.; Toda, E.; Kashihara, M.; Ishida, Y.; Hiei, Y.; Isobe, S.; Shirasawa, K.; Hirakawa, H.; Okamoto, T.; Komari, T.
10.1101/2021.01.20.427397 — plant biology — Posted on 2021-01-21
1533 The VTA-BLA-NAc circuit for sex reward inhibited by VTA GABAergic neurons under stress in male mice
Yan, H.; Sun, L.; You, J.; Cui, M.; Sun, F.; Wang, J.; Wang, W.; Wang, D.; Liu, D.; Xu, Z.; Qiu, C.; Liu, B.
10.1101/2021.01.20.427537 — neuroscience — Posted on 2021-01-21
1535 CrossTalkeR: Analysis and Visualisation of Ligand Receptor Networks
Nagai, J. S.; Leimkuehler, N.; Schneider, R.; Gesteira Costa Filho, I.
10.1101/2021.01.20.427390 — systems biology — Posted on 2021-01-21
1536 Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates
Chuprakov, S.; Ogunkoya, A. O.; Barfield, R. M.; Bauzon, M.; Hickle, C.; Kim, Y. C.; Yeo, D.; Zhang, F.; Rabuka, D.; Drake, P. M.
10.1101/2021.01.19.427340 — pharmacology and toxicology — Posted on 2021-01-21
1537 KSR1-and ERK-dependent Translational Regulation of the Epithelial-to-Mesenchymal Transition
Rao, C.; Frodyma, D. E.; Southekal, S.; Svoboda, R. A.; Black, A. R.; Guda, C.; Mizutani, T.; Clever, H.; Johnson, K. R.; Fisher, K. W.; Lewis, R. E.
10.1101/2021.01.18.427224 — cancer biology — Posted on 2021-01-21
1540 Evolution of Single Gyroid Photonic Crystals in Bird Feathers
SARANATHAN, V.; Narayanan, S.; Sandy, A. R.; Dufresne, E. R.; Prum, R. O.
10.1101/2020.08.27.271213 — evolutionary biology — Posted on 2021-01-21
1546 T cell self-reactivity during thymic development dictates the timing of positive selection
Lutes, L. K.; Steier, Z.; McIntyre, L. L.; Pandey, S.; Kaminski, J.; Hoover, A. R.; Ariotti, S.; Streets, A.; Yosef, N.; Robey, E. A.
10.1101/2021.01.18.427079 — developmental biology — Posted on 2021-01-21
1547 Molecular mechanism for kinesin-1 direct membrane recognition
Anton, Z.; Weijman, J. F.; Williams, C.; Moody, E. R. R.; Mantell, J.; Yip, Y. Y.; Cross, J. A.; Williams, T. A.; Steiner, R. A.; Crump, M.; Woolfson, D. N.; Dodding, M. P.
10.1101/2021.01.20.427326 — cell biology — Posted on 2021-01-21
1548 MYBL2 regulates ATM to control replication initiation and prevent replication stress in pluripotent stem cells
Blakemore, D.; Almaghrabi, R.; Vilaplana, N.; Gonzalez, E.; Moya, M.; Ward, C.; Murphy, G.; Gambus, A.; Petermann, E.; Stewart, G.; Garcia, P.
10.1101/2020.06.04.131276 — cell biology — Posted on 2021-01-21
1549 Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration
Arts, J. J. G.; Mahlandt, E. K.; Grönloh, M.; Schimmel, L.; Noordstra, I.; van Steen, A. C. I.; Tol, S.; van Rijssel, J.; Nolte, M. A.; Postma, M.; Khuon, S.; Heddleston, J. M.; Wait, E.; Chew, T. L.; Winter, M.; Montanez, E.; Goedhart, J.; van Buul, J. D.
10.1101/2021.01.18.427135 — cell biology — Posted on 2021-01-21
1551 Myocardial BDNF regulates cardiac bioenergetics through the transcription factor Yin Yang 1
Yang, X.; Zhang, M.; Zimmerman, R. J.; Wang, Q.; Wei, A.-c.; Zhu, G.; Bedja, D.; Jiang, H.; Shiva, S. S.; Scott, I.; O'Rourke, B.; Kass, D. A.; Paolocci, N.; Feng, N.
10.1101/2021.01.19.427213 — molecular biology — Posted on 2021-01-21
1554 Sex-specific differences in the function and differentiation of ABCsmark TLR7-driven immunopathogenesis
Ricker, E.; Manni, M.; Flores-Castro, D.; Jenkins, D.; Gupta, S.; Rivera-Correa, J.; Meng, W.; Rosenfeld, A. M.; Pannellini, T.; Chinenov, Y.; Sculco, P. K.; Jessberger, R.; Luning Prak, E. T.; Pernis, A. B.
10.1101/2021.01.20.427400 — immunology — Posted on 2021-01-21
1555 Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics
Serrano-Lopez, J.; Hegde, S.; Kumar, S.; Serrano, J.; Fang, J.; Wellendorf, A.; Roche, P.; Rangel, Y.; Carrington, L. J.; Geiger, H.; Grimes, L.; Luther, S.; Maillard, I.; Sanchez-Garcia, J.; Starczynowski, D.; Cancelas, J.
10.1101/2021.01.20.427403 — immunology — Posted on 2021-01-21
1556 Analysis of HIV Reservoirs in Cellular Conjugates from Peripheral Blood
Boritz, E.; Perez, L.; Crespo-Velez, D.; Lee, M.; Zakaria, S.; Poole, A.; Bell, J.; Migueles, S.; Chun, T.-W.; Moir, S.; Maldarelli, F.
10.1101/2021.01.19.427248 — immunology — Posted on 2021-01-21
1557 Glycolic acid protects neurons against ischemia in vitro and in two animal models of stroke
Chovsepian, A.; Berchtold, D.; Winek, K.; Mamrak, U.; Ramirez-Alvarez, I.; Dening, Y.; Weitbrecht, L.; Dames, C.; Aillery, M.; Fernandez-Sanz, C.; Dieterich, M.; Falkai, P.; Plesnila, N.; Meisel, A.; Pan-Montojo, F. J.
10.1101/2020.11.24.396051 — neuroscience — Posted on 2021-01-21
1560 Hyperoxia Inhibits the Growth of Mouse Forebrain Oligodendrocyte Progenitors
Moore, L. M.; McLane, L. E.; Wahl, S. E.; Ornelas, I.; Wood, T. L.; Canoll, P. D.; Levison, S. W.
10.1101/2021.01.20.427261 — neuroscience — Posted on 2021-01-21
1566 Single Cell Biological Microlasers Powered by Deep Learning
Qiao, Z.; Sun, W.; Zhang, N.; Jie, R. A.; CHEW, S. Y.; Chen, Y.-C.
10.1101/2021.01.21.427584 — biophysics — Posted on 2021-01-21
1567 Quickomics: exploring omics data in an intuitive, interactive and informative manner
Gao, B.; Zhu, J.; Negi, S.; Zhang, X.; Gyoneva, S.; Casey, F.; Wei, R.; Zhang, B.
10.1101/2021.01.19.427296 — bioinformatics — Posted on 2021-01-21
1573 Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
Teano, G.; Concia, L.; Carron, L.; Wolff, L.; Adamusova, K.; Fojtova, M.; Bourge, M.; Kramdi, A.; Colot, V.; Grossniklaus, U.; Bowler, C.; Baroux, C.; Carbone, A.; Probst, A. V.; Prochazkova Schrumpfova, P.; Fajkus, J.; Amiard, S.; Grob, S.; Bourbousse, C.; Barneche, F.
10.1101/2020.11.28.402172 — molecular biology — Posted on 2021-01-21
1574 Nodal GABA facilitates axon spike transmission in the spinal cord.
Hari, K.; Lucas-Osma, A. M.; Metz, K.; Lin, S.; Pardell, N.; Roszko, D.; Black, S.; Minarik, A.; Singla, R.; Stephens, M. J.; Fouad, K.; Jones, K. E.; Gorassini, M. A.; Fenrich, K. K.; Li, Y.; Bennett, D. J.
10.1101/2021.01.20.427494 — neuroscience — Posted on 2021-01-21
1578 A centrifuge-based method for identifying novel genetic traits that affect root-substrate adhesion in Arabidopsis thaliana
Eldridge, B. M.; Larson, E. R.; Weldon, L.; Smyth, K. M.; Sellin, A. N.; Chenchiah, I. V.; Liverpool, T. B.; Grierson, C. S.
10.1101/2020.05.14.095448 — plant biology — Posted on 2021-01-21
1579 Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics
Velten, L.; Story, B. A.; Hernandez-Malmierca, P.; Leonce, D. R.; Milbank, J.; Paulsen, M.; Demir, A.; Szu-Tu, C.; Froemel, R.; Lutz, C.; Nowak, D.; Jann, J.-C.; Pabst, C.; Boch, T.; Hofmann, W.-K.; Mueller-Tidow, C.; Raffel, S.; Trumpp, A.; Haas, S.; Steinmetz, L. M.
10.1101/500108 — genomics — Posted on 2021-01-21
1587 Mathematical modeling of the Candida albicans yeast to hyphal transition reveals novel control strategies
Wooten, D. J.; Zanudo, J. G. T.; Murrugarra, D.; Perry, A.; Dongari-Bagtzoglou, A.; Laubenbacher, R.; Nobile, C.; Albert, R.
10.1101/2021.01.20.427417 — systems biology — Posted on 2021-01-20
1590 Pharmacokinetics of long-term low-dose oral rapamycin in four healthy middle-aged companion dogs
Evans, J. B.; Morrison, A. J.; Javors, M. A.; Lopez-Cruzan, M.; Promislow, D. E.; Kaeberlein, M.; Creevy, K. E.
10.1101/2021.01.20.427425 — pharmacology and toxicology — Posted on 2021-01-20
1594 Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world smallest mammalian divers
He, K.; Eastman, T. G.; Czolacz, H.; Li, S.; Shinohara, A.; Kawada, S.-i.; Springer, M.; Berenbrink, M.; Campbell, K. L.
10.1101/2021.01.14.426706 — evolutionary biology — Posted on 2021-01-20
1597 {-}Multivariable Association Discovery in Population-scale Meta-omics Studies
Mallick, H.; Rahnavard, A.; McIver, L. J.; Ma, S.; Zhang, Y.; Nguyen, L. H.; Tickle, T. L.; Weingart, G.; Ren, B.; Schwager, E. H.; Chatterjee, S.; Thompson, K. N.; Wilkinson, J. E.; Subramanian, A.; Lu, Y.; Waldron, L.; Paulson, J. N.; Franzosa, E. A.; Bravo, H. C.; Huttenhower, C.
10.1101/2021.01.20.427420 — microbiology — Posted on 2021-01-20
1600 RBCeq: An Integrated Bioinformatics Algorithm Designed to Improve Blood Type Compatibility Testing
Jadhao, S. S.; Davison, C.; Roulis, E. V.; Schoeman, E. M.; Divate, M. D.; Shankar, A. J.; Lee, S.; Pecheniuk, N. M.; Irving, D. O.; Hyland, C. A.; Flower, R. L.; Nagaraj, S. H.
10.1101/2021.01.13.426510 — bioinformatics — Posted on 2021-01-20
1601 Polymorphic SNPs, short tandem repeats and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrains
Mortazavi, M.; Ren, Y.; Saini, S.; Antaki, D.; St. Pierre, C.; Williams, A.; Sohni, A.; Wilkinson, M.; Gymrek, M.; Sebat, J.; Palmer, A. A.
10.1101/2020.03.16.993683 — genomics — Posted on 2021-01-20
1602 Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes
Vysotskiy, M.; Zhong, X.; Miller-Fleming, T. W.; Zhou, D.; Autism Working Group of the Psychiatric Genomics Consortium, ; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, ; Schizophrenia Working Group of the Psychiatric Genomics Consortium, ; Cox, N. J.; Weiss, L. A.
10.1101/2020.06.23.166181 — genetics — Posted on 2021-01-20
1603 GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms
Ward, L. D.; Tu, H.-C.; Quenneville, C. B.; Tsour, S.; Flynn-Carroll, A. O.; Parker, M. M.; Deaton, A. M.; Haslett, P. A. J.; Lotta, L. A.; Verweij, N.; Ferreira, M. A. R.; Regeneron Genetics Center, ; Geisinger-Regeneron DiscovEHR Collaboration, ; Baras, A.; Hinkle, G.; Nioi, P.
10.1101/2020.05.19.104570 — genetics — Posted on 2021-01-20
1605 Phosphoproteomics reveals new insights into the role of PknG during the persistence of pathogenic mycobacteria in host macrophages
Baros-Steyl, S. S.; Nakedi, K. C.; Ganief, T. A.; Okendo, J. O.; Tabb, D. L.; Soares, N. C.; Blackburn, J. M.
10.1101/2021.01.19.427367 — molecular biology — Posted on 2021-01-20
1608 A Large-Scale Brain Network Mechanism for Increased Seizure Propensity in Alzheimer's Disease
Tait, L.; Lopes, M. A.; Stothart, G.; Baker, J.; Kazanina, N.; Zhang, J.; Goodfellow, M.
10.1101/2021.01.19.427236 — neuroscience — Posted on 2021-01-20
1609 Genetic influences on hub connectivity of the human connectome
Arnatkeviciute, A.; Fulcher, B. D.; Oldham, S.; Tiego, J.; Paquola, C.; Gerring, Z. F.; Aquino, K. M.; Hawi, Z.; Johnson, B.; Ball, G. M.; Klein, M.; Deco, G.; Franke, B.; Bellgrove, M.; Fornito, A.
10.1101/2020.06.21.163915 — neuroscience — Posted on 2021-01-20
1611 Coiled coils 9-to-5: Rational de novo design of α-helical barrels with tunable oligomeric states
Dawson, W. M.; Martin, F. J.; Rhys, G. G.; Shelley, K. L.; Brady, R. L.; Woolfson, D. N.
10.1101/2021.01.20.427391 — biochemistry — Posted on 2021-01-20
1614 The power of dying slowly - persistence as unintentional dormancy
Rebelo, J. S.; Domingues, C. P. F.; Monteiro, F.; Nogueira, T.; Dionisio, F.
10.1101/2021.01.20.427471 — microbiology — Posted on 2021-01-20
1615 Genome recombination-mediated tRNA up-regulation conducts general antibiotic resistance of bacteria at early stage
Fang, H.; Zeng, G.; Zhao, J.; Zheng, T.; Xu, L.; Gu, W.; Liu, Y.; Zhang, J.; Sun, X.; Zhang, G.
10.1101/2021.01.19.427372 — microbiology — Posted on 2021-01-20
1619 Itaconate and derivatives reduce interferon responses and inflammation in influenza A infection
Sohail, A.; Iqbal, A.; Sahini, N.; Tantawy, M.; Winterhoff, M.; Geffers, R.; Ebensen, T.; Schughart, K.; Pils, M.; Chen, F.; Guzman, C. A.; Preusse, M.; Pleschka, S.; Mostafa, A.; Falk, C.; Michelucci, A.; Pessler, F.
10.1101/2021.01.20.427392 — immunology — Posted on 2021-01-20
1624 DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets
Wilson, S. B.; Howden, S. E.; Vanslambrouck, J. M.; Dorison, A.; Alquicira-Hernandez, J.; Powell, J. E.; Little, M. H.
10.1101/2021.01.20.427346 — bioinformatics — Posted on 2021-01-20
1625 Real-Time, Direct Classification of Nanopore Signals with SquiggleNet
Bao, Y.; Wadden, J.; Erb-Downward, J. R.; Ranjan, P.; Dickson, R. P.; Blaauw, D.; Welch, J. D.
10.1101/2021.01.15.426907 — bioinformatics — Posted on 2021-01-20
1627 Microarray screening reveals a non-conventional SUMO-binding mode linked to DNA repair by non-homologous end-joining
Cabello-Lobato, M. J.; Jenner, M.; Loch, C. M.; Jackson, S. P.; Wu, Q.; Cliff, M. J.; Schmidt, C. K.
10.1101/2021.01.20.427433 — biochemistry — Posted on 2021-01-20
1628 Enrichment of Zα domains at cytoplasmic stress granules is due to their innate ability to bind nucleic acids
Gabriel, L.; Srinivasan, B.; Kus, K.; Mata, J. F.; Amorim, M.-J.; Jansen, L. E. T.; Athanasiadis, A.
10.1101/2021.01.20.427402 — biochemistry — Posted on 2021-01-20
1629 Biochemical and Structural Characterization of Two Cif-Like Epoxide Hydrolases from Burkholderia cenocepacia
Taher, N. M.; Hvorecny, K. L.; Burke, C. M.; Gilman, M. S. A.; Heussler, G. E.; Adolf-Bryfogle, J.; Bahl, C. D.; O'Toole, G. A.; Madden, D. R.
10.1101/2021.01.20.427036 — biochemistry — Posted on 2021-01-20
1630 H2A.B is a cancer/testis factor involved in activation of ribosome biogenesis in Hodgkin Lymphoma
Tremethick, D.; Xuanzhao, J.; Wen, J. J.; Pavwer, E.; Yu-Huan, W.; Sun, G.; Pullman, A.; Dahlstrome, J. E.; Soboleva, T.
10.1101/2021.01.19.427265 — genomics — Posted on 2021-01-20
1635 Relocation of rDNA repeats for repair is dependent on SUMO-mediated nucleolar release by the Cdc48/p97 segregase
Capella, M.; Mandemaker, I. K.; den Brave, F.; Martin Caballero, L.; Pfander, B.; Ladurner, A. G.; Jentsch, S.; Braun, S. J.
10.1101/2021.01.05.425376 — molecular biology — Posted on 2021-01-20
1638 ATGs ubiquitination is required for circumsporozoite protein to subvert host innate immunity against malaria liver stage
Xu, W.; Zheng, H.; Lu, X.; Li, K.; Zhu, F.; Zhao, C.; Liu, T.; Ding, Y.; Fu, Y.; Zhang, K.; Zhou, T.; Dai, J.; Wu, Y.
10.1101/2021.01.20.427456 — microbiology — Posted on 2021-01-20
1640 RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signalling
Chen, K.; Demarco, B.; Heilig, R.; Ramos, S.; Grayczyk, J.; Assenmacher, C.-A.; Radaelli, E.; Joannas, L.; Henao-Mejia, J.; Brodsky, I.; Broz, P.
10.1101/2021.01.20.427379 — immunology — Posted on 2021-01-20
1644 Topological analysis of single-cell data reveals shared glial landscape of macular degeneration and neurodegenerative diseases
Kuchroo, M.; DiStasio, M.; Calapkulu, E.; Ige, M.; Zhang, L.; Sheth, A. H.; Menon, M.; Xing, Y.; Gigante, S. A.; Huang, J.; Dhodhapkar, R. M.; Rieck, B. A.; Wolf, G.; Krishnaswamy, S.; Hafler, B. P.
10.1101/2021.01.19.427286 — neuroscience — Posted on 2021-01-20
1645 Inhibition of microglial GBA hampers the microglia-mediated anti-oxidant and protective response in neurons
Brunialti, E.; Villa, A.; Mekhaeil, M.; Mornata, F.; Vegeto, E.; Maggi, A.; Di Monte, D. A.; Ciana, P.
10.1101/2021.01.20.427380 — neuroscience — Posted on 2021-01-20
1646 The bacterial virulence factors rhamnolipids and their (R)-3-hydroxyalkanoate precursors activate Arabidopsis innate immunity through two independent mechanisms
Schellenberger, R.; Crouzet, J.; Nickzad, A.; Kutschera, A.; Gerster, T.; Borie, N.; Dawid, C.; Cloutier, M.; Villaume, S.; Dhondt-Cordelier, S.; Hubert, J.; Cordelier, S.; Mazeyrat-Gourbeyre, F.; Schmid, C.; Ongena, M.; Renault, J.-H.; Haudrechy, A.; Hofmann, T.; Baillieul, F.; Clement, C.; Zipfel, C.; Gauthier, C.; Deziel, E.; Ranf, S.; Dorey, S.
10.1101/2020.12.18.423392 — plant biology — Posted on 2021-01-20
1648 Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage
Amen, A. M.; Fellmann, C.; Soczek, K. M.; Ren, S. M.; Lew, R. J.; Knott, G. J.; Park, J. E.; McKinney, A. M.; Mancini, A.; Doudna, J. A.; Costello, J. F.
10.1101/2020.04.25.061606 — cancer biology — Posted on 2021-01-20
1649 The Sequenced Genomes of Non-Flowering Land Plants Reveal the (R)Evolutionary History of Peptide Signaling
Furumizu, C.; Krabberod, A. K.; Hammerstad, M.; Alling, R. M.; Wildhagen, M.; Sawa, S.; Aalen, R. B.
10.1101/2020.06.02.130120 — evolutionary biology — Posted on 2021-01-20
1651 Genetic population structure constrains local adaptation in sticklebacks
Kemppainen, P. M.; Li, Z.; Rastas, P.; Loytynoja, A.; Fang, B.; Guo, B.; Shikano, T.; Yang, J.; Merila, J.
10.1101/2020.01.17.908970 — evolutionary biology — Posted on 2021-01-20
1654 The sensitivity of ECG contamination to surgical implantation site in adaptive closed-loop neurostimulation systems
Neumann, W.-J.; Memarian Sorkhabi, M.; Benjaber, M.; Feldmann, L. K.; Saryyeva, A.; Krauss, J. K.; Sieger, T.; Jech, R.; Contarino, M. F.; Tinkhauser, G.; Pollo, C.; Palmisano, C.; Isaias, I. U.; Cummins, D.; Little, S. J.; Starr, P. A.; Kokkinos, V.; Schneider, G.-H.; Herrington, T.; Brown, P.; Richardson, R. M.; Kuehn, A. A.; Denison, T.
10.1101/2021.01.15.426827 — neuroscience — Posted on 2021-01-20
1655 Cortico-striatal activity driving compulsive reward seeking
Harada, M.; Pascoli, V.; Hiver, A.; Flakowski, J.; Lüscher, C.
10.1101/789495 — neuroscience — Posted on 2021-01-20
1656 Disrupted visual cortical plasticity in early neurodegeneration
Papanikolaou, A.; Rodrigues, F. R.; Holeniewska, J.; Phillips, K. G.; Saleem, A. B.; Solomon, S. G.
10.1101/2020.11.02.365767 — neuroscience — Posted on 2021-01-20
1657 Peripheral kappa opioid receptor activation drives cold hypersensitivity in mice
Madasu, M. K.; Thang, L. V.; Chilukuri, P.; Palanisamy, S.; Arackal, J. S.; Sheahan, T. D.; Foshage, A. M.; Houghten, R. A.; McLaughlin, J. P.; McCall, J. G.; Al-Hasani, R.
10.1101/2020.10.04.325118 — neuroscience — Posted on 2021-01-20
1659 Conserved long-range base pairings associated with pre-mRNA processing of human protein-coding genes
Kalmykova, S.; Kalinina, M.; Denisov, S.; Mironov, A.; Skvortsov, D.; Guigo, R.; Pervouchine, D. D.
10.1101/2020.05.05.076927 — bioinformatics — Posted on 2021-01-20
1662 Genetic variation reveals individual-level climate tracking across the full annual cycle of a migratory bird
Bay, R. A.; Karp, D. S.; Saracco, J. F.; Anderegg, W. R.; Frishkoff, L.; Wiedenfeld, D.; Smith, T. B.; Ruegg, K.
10.1101/2020.04.15.043331 — evolutionary biology — Posted on 2021-01-20
1663 Ventricular, atrial and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak.
Ivanovitch, K.; Soro-Barrio, P.; Chakravarty, P.; Jones, R. A.; Bell, D. M.; Mousavy Gharavy, S. N.; Stamataki, D.; Delile, J.; Smith, J. C.; Briscoe, J.
10.1101/2020.07.12.198994 — developmental biology — Posted on 2021-01-20
1664 A two-phase model of skin epidermal stratification: lessons from centrosomes
Damen, M.; Wirtz, L.; Soroka, E.; Khatif, H.; Kukat, C.; Simons, B. D.; Bazzi, H.
10.1101/2020.07.24.219493 — developmental biology — Posted on 2021-01-20
1665 Effects of the selective dopamine D3 receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice
Botz-Zapp, C. A.; Foster, S. L.; Pulley, D. M.; Hempel, B.; Bi, G.-H.; Xi, Z.-X.; Newman, A. H.; Weinshenker, D.; Manvich, D. F.
10.1101/2020.04.07.029918 — neuroscience — Posted on 2021-01-20
1666 The relationship between EEG and fMRI connectomes is reproducible across simultaneous EEG-fMRI studies from 1.5T to 7T
Wirsich, J.; Jorge, J.; Iannotti, G. R.; Shamshiri, E. A.; Grouiller, F.; Abreu, R.; Lazeyras, F.; Giraud, A.-L.; Gruetter, R.; Sadaghiani, S.; Vulliemoz, S.
10.1101/2020.06.16.154625 — neuroscience — Posted on 2021-01-20
1669 Modelling cell guidance and curvature control in evolving biological tissues
Hegarty-Cremer, S. G. D.; Simpson, M. J.; Andersen, T. L.; Buenzli, P. R.
10.1101/2020.07.10.197020 — biophysics — Posted on 2021-01-20
1670 Generation and characterization of a laforin nanobody inhibitor
Simmons, Z. R.; Sharma, S.; Wayne, J.; Li, S.; Vander Kooi, C. W.; Gentry, M. S.
10.1101/2021.01.20.426524 — biochemistry — Posted on 2021-01-20
1671 Use Of Canine Olfactory Detection For COVID-19 Testing Study On U.A.E. Trained Detection Dog Sensitivity
Granjean, D.; Al Marzooqi, D. H.; Lecoq-Julien, C.; Al Hammadi, H. K.; Alvergnat, G.; Al Blooshi, K. M.; Al Mazrooei, S. K.; Alhmoudi, M. S.; Al Ahbabi, F. M.; Mohammed, Y. S.; Al Falasi, N. M.; Almheiri, N. M.; Al Blooshi, S. M.; Muzzin, Q.; Desquilbet, L.
10.1101/2021.01.20.427105 — animal behavior and cognition — Posted on 2021-01-20
1672 Multiple dimensions of social motivation in adult female degus
Lidhar, N. K.; Thakur, A.; David, A.-J.; Takehara-Nishiuchi, K.; Insel, N.
10.1101/2020.07.07.191486 — animal behavior and cognition — Posted on 2021-01-20
1676 A Universal Bacteriophage T4 Nanoparticle Platform to Design Multiplex SARS-CoV-2 Vaccine Candidates by CRISPR Engineering
Rao, V. B.; Zhu, J.; Ananthaswamy, N.; Jain, S.; Batra, H.; Tang, W.-C.; Lewry, D. A.; Richards, M. L.; David, S. A.; Kilgore, P. B.; Sha, J.; Drelich, A.; Tseng, C.-T.; Chopra, A. K.
10.1101/2021.01.19.427310 — microbiology — Posted on 2021-01-20
1677 Phylogenomics reveals that Asaia symbionts from insects underwent convergent genome reduction, preserving an insecticide-degrading gene
Comandatore, F.; Damiani, C.; Cappelli, A.; Martins Ribolla, P. E.; Gasperi, G.; Gradoni, F.; Capelli, G.; Piazza, A.; Montarsi, F.; Mancini, M. V.; Rossi, P.; Ricci, I.; Bandi, C.; Favia, G.
10.1101/2020.10.30.363036 — microbiology — Posted on 2021-01-20
1678 Neutralizing and protective human monoclonal antibodies recognizing the N-terminaldomain of the SARS-CoV-2 spike protein
Suryadevara, N.; Shrihari, S.; Gilchuk, P.; VanBlargan, L.; Binshtein, E.; Zost, S.; Nargi, R.; Sutton, R.; Winkler, E. S.; Chen, E. C.; Fouch, M. E.; Davidson, E.; Doranz, B.; Carnahan, R. H.; Thackray, L.; Diamond, M. D.; Crowe, J. E.
10.1101/2021.01.19.427324 — immunology — Posted on 2021-01-20
1681 Neural harmonics of syntactic structure
Tavano, A.; Blohm, S.; Knoop, C.; Muralikrishnan, R.; Scharinger, M.; Wagner, V.; Thiele, D.; Ghitza, O.; Ding, N.; Menninghaus, W.; Poeppel, D.
10.1101/2020.04.08.031575 — neuroscience — Posted on 2021-01-20
1683 Wild-captive contrasts in non-vocal communicative repertoires and functional specificity in orang-utans
Froehlich, M.; Bartolotta, N.; Fryns, C.; Wagner, C.; Momon, L.; Jaffrezic, M.; Mitra Setia, T.; Schuppli, C.; van Noordwijk, M. A.; van Schaik, C. P.
10.1101/2021.01.19.426493 — animal behavior and cognition — Posted on 2021-01-20
1684 Young domestic chicks spontaneously represent the absence of objects
Szabo, E.; Chiandetti, C.; Teglas, E.; Versace, E.; Csibra, G.; Kovacs, A. M.; Vallortigara, G.
10.1101/2021.01.20.427266 — animal behavior and cognition — Posted on 2021-01-20
1685 Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts
Valesano, A. L.; Rumfelt, K. E.; Dimcheff, D. E.; Blair, C. N.; Fitzsimmons, W. J.; Petrie, J. G.; Martin, E. T.; Lauring, A. S.
10.1101/2021.01.19.427330 — microbiology — Posted on 2021-01-20
1686 Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model.
Kurup, D.; Malherbe, D. C.; Wirblich, C.; Lambert, R.; Ronk, A.; Zabihi Diba, L.; Bukreyev, A.; Schnell, M. J.
10.1101/2021.01.19.427373 — microbiology — Posted on 2021-01-20
1687 An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins
Blawas, A. M.; Ware, K. E.; Schmaltz, E.; Spruance, J.; Allen, A. S.; West, N.; Devos, N.; Corcoran, D. L.; Nowacek, D. P.; Eward, W. C.; Fahlman, A.; Somarelli, J. A.
10.1101/2021.01.20.425775 — physiology — Posted on 2021-01-20
1688 Enhancer-associated H3K4 methylation safeguards in vitro germlinecompetence
Bleckwehl, T.; Crispatzu, G.; Schaaf, K.; Respuela, P.; Bartusel, M.; Benson, L.; Clark, S. J.; Dorighi, K. M.; Barral, A.; Laugsch, M.; van IJcken, W.; Manzanares, M.; Wysocka, J.; Reik, W.; Rada-Iglesias, A.
10.1101/2020.07.07.192427 — genomics — Posted on 2021-01-20
1692 Self-organization and information transfer in Antarctic krill swarms
Burns, A. L.; Schaerf, T. M.; Lizier, J. T.; Kawaguchi, S.; Cox, M.; King, R.; Krause, J.; Ward, A. J. W.
10.1101/2021.01.19.427357 — animal behavior and cognition — Posted on 2021-01-20
1693 Breeding seasonality generates reproductive trade-offs in a long-lived mammal
Dezeure, J.; Baniel, A.; Carter, A. J.; Cowlishaw, G.; Godelle, B.; Huchard, E.
10.1101/2021.01.19.427238 — evolutionary biology — Posted on 2021-01-20
1696 Polycomb suppresses a female gene regulatory network in Sertoli cells
Maezawa, S.; Yukawa, M.; Hasegawa, K.; Sugiyama, R.; Hu, M.; Vidal, M.; Koseki, H.; Barski, A.; DeFalco, T.; Namekawa, S. H.
10.1101/2021.01.19.427322 — developmental biology — Posted on 2021-01-20
1698 CometChip Enables Parallel Analysis of Multiple DNA Repair Activities
Ge, J.; Ngo, L. P.; Kaushal, S.; Tay, I. J.; Thadhani, E.; Kay, J. E.; Mazzucato, P.; Chow, D. N.; Fessler, J. L.; Weingeist, D. M.; Sobol, R. W.; Samson, L. D.; Floyd, S. R.; Engelward, B. P.
10.1101/2021.01.19.427336 — molecular biology — Posted on 2021-01-20
1699 Type 2 Diabetes Modifies Skeletal Muscle Gene Expression Response to Gastric Bypass Surgery
Barberio, M. D.; Dohm, G. L.; Pories, W. J.; Gadaleta, N. A.; Houmard, J. A.; Nadler, E. P.; Hubal, M. J.
10.1101/2021.01.19.427352 — molecular biology — Posted on 2021-01-20
1701 Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model
Xia, D.; Lianoglou, S.; Sandmann, T.; Calvert, M.; Suh, J. H.; Thomsen, E.; Dugas, J.; Pizzo, M. E.; DeVos, S. L.; Earr, T. K.; Lin, C.-C.; Davis, S.; Ha, C.; Nguyen, H.; Chau, R.; Yulyaningsih, E.; Solanoy, H.; Masoud, S. T.; Liang, R.; Lin, K.; Thorne, R. G.; Garceau, D.; Whitesell, J. D.; Sasner, M.; Harris, J. A.; Scearce-Levie, K.; Lewcock, J. W.; Paolo, G. D.; Sanchez, P. E.
10.1101/2021.01.19.426731 — neuroscience — Posted on 2021-01-20
1703 Conserved Architecture of Brain Transcriptome Changes between Alzheimer's Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions
Wang, X.; Allen, M.; Reddy, J. S.; Carrasquillo, M. M.; Asmann, Y. W.; Funk, C.; Nguyen, T. T.; Malphrus, K. G.; Younkin, S. G.; Dickson, D. W.; Price, N.; Golde, T. E.; Ertekin-Taner, N.
10.1101/2021.01.18.426999 — neuroscience — Posted on 2021-01-20
1705 Architecture of the Neuro-Glia-Vascular System
Zisis, E.; Keller, D.; Kanari, L.; Arnaudon, A.; Gevaert, M.; Delemontex, T.; Coste, B.; Foni, A.; Marwan, A.; Cali, C.; Hess, K.; Schürmann, F.; Markram, H.
10.1101/2021.01.19.427241 — neuroscience — Posted on 2021-01-20
1709 The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress
Llamas, E.; Torres-Montilla, S.; Lee, H. J.; Barja, M. V.; Schlimgen, E.; Dunken, N.; Wagle, P.; Werr, W.; Zuccaro, A.; Rodriguez-Concepcion, M.; Vilchez, D.
10.1101/2021.01.19.427268 — plant biology — Posted on 2021-01-20
1711 Plants export 2-monopalmitin and supply both fatty acyl and glyceryl moieties to arbuscular mycorrhizal fungi
Luginbuehl, L.; van Erp, H.; Cheeld, H.; Mysore, K. S.; Wen, J.; Oldroyd, G. E.; Eastmond, P. J.
10.1101/2021.01.19.427311 — plant biology — Posted on 2021-01-20
1712 A conserved regulatory module regulates receptor kinase signaling in immunity and development
DeFalco, T. A.; Anne, P.; James, S. R.; Willoughby, A.; Johanndrees, O.; Genolet, Y.; Pullen, A.-M.; zipfel, c.; Hardtke, C.; Nimchuk, Z. L.
10.1101/2021.01.19.427293 — plant biology — Posted on 2021-01-20
1713 Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanics.
Nyga, A.; Munoz, J.; Dercksen, S.; Fornabaio, G.; Uroz, M.; Trepat, X.; Baum, B.; Matthews, H. K.; Conte, V.
10.1101/2021.01.19.427283 — cancer biology — Posted on 2021-01-20
1714 Convergent evolution of resistance pathways during early stage breast cancer treatment with combination cell cycle (CDK) and endocrine inhibitors
Griffiths, J. I.; Chen, J.; Cosgrove, P. A.; O'Dea, A.; Sharma, P.; Ma, C.; Trivedi, M.; Kalinsky, K.; Wisinski, K. B.; O'Regan, R.; Makhoul, , I.; Spring, L. M.; Bardia, A.; Adler, F. R.; Cohen, A. L.; Chang, J. T.; Khan, Q. J.; Bild, A.
10.1101/2021.01.19.427299 — cancer biology — Posted on 2021-01-20
1716 Single particle combinatorial multiplexed liposome fusion mediated by DNA
Malle, M. G.; Loffler, P. M. G.; Bohr, S. S.-R.; Sletfjerding, M. B.; Risgaard, N. A.; Jensen, S. B.; Zhang, M.; Hedegaard, P.; Vogel, S.; Hatzakis, N. S.
10.1101/2021.01.19.427313 — biophysics — Posted on 2021-01-20
1719 Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus
Meier-Stephenson, V.; Badmalia, M. D.; Mrozowich, T.; Lau, K. C.; Schultz, S. K.; Gemmill, D. L.; Osiowy, C.; van Marle, G.; Coffin, C. S.; Patel, T. R.
10.1101/2021.01.19.427307 — biophysics — Posted on 2021-01-20
1721 Integration of spatial transcriptomic and single cell sequencing identifies expression patterns underlying immune and epithelial cell cross-talk in acute kidney injury
Melo Ferreira, R.; Sabo, A. R.; Winfree, S.; Collins, K. S.; Janosevic, D.; Gulbronson, C.; Casbon, L.; Cheng, Y.-H.; Barwinska, D.; Ferkowicz, M. J.; Xuei, X.; Dunn, K. W.; Kelly, K. J.; Sutton, T. A.; Hato, T.; Dagher, P. C.; El-Achkar, T. M.; Eadon, M. T.
10.1101/2021.01.19.427258 — bioinformatics — Posted on 2021-01-20
1723 Deep Learning Achieves Neuroradiologist-Level Performance in Detecting Hydrocephalus
Huang, Y.; Moreno, R.; Malani, R.; Meng, A.; Swinburne, N.; Holodny, A. I.; Choi, Y.; Parra, L. C.; Young, R. J.
10.1101/2021.01.19.427328 — bioinformatics — Posted on 2021-01-20
1726 Impact of sterilization on a conjugated polymer based bioelectronic patch
Yan, Y.; Travaglini, L.; Lau, K.; Rnjak-Kovacina, J.; Eslami, M.; Yang, S.; Lauto, A.; Officer, D.; Mawad, D.
10.1101/2021.01.19.427349 — bioengineering — Posted on 2021-01-20
1727 A scalable pipeline for local ancestry inference using tens of thousands of reference haplotypes
Durand, E. Y.; Do, C. B.; Wilton, P. R.; Mountain, J. L.; Auton, A.; Poznik, G. D.; Macpherson, J. M.
10.1101/2021.01.19.427308 — genomics — Posted on 2021-01-20
1730 Protein-coding repeat polymorphisms strongly shape diverse human phenotypes
Mukamel, R. E.; Handsaker, R. E.; Sherman, M. A.; Barton, A. R.; Zheng, Y.; McCarroll, S. A.; Loh, P.-R.
10.1101/2021.01.19.427332 — genetics — Posted on 2021-01-20
1732 Universal markers support a long inter-domain branch between Archaea and Bacteria
Moody, E. R. R.; Mahendrarajah, T. A.; Dombrowski, N.; Clark, J. W.; Petitjean, C.; Offre, P.; Szöllosi, G. J.; Spang, A.; Williams, T. A.
10.1101/2021.01.19.427276 — evolutionary biology — Posted on 2021-01-20
1735 Sahul's megafauna were vulnerable to extinction due to their position in the trophic network
Llewelyn, J.; Strona, G. S.; McDowell, M.; Johnson, C.; Peters, K.; Stouffer, D. B.; de Visser, S. N.; Saltre, F. B.; Bradshaw, C. J. A.
10.1101/2021.01.19.427338 — ecology — Posted on 2021-01-20
1736 VISUAL network analysis reveals the role of BEH3 as a stabilizer in the secondary vascular development in Arabidopsis
Furuya, T.; Saito, M.; Uchimura, H.; Satake, A.; Nosaki, S.; Miyakawa, T.; Shimadzu, S.; Yamori, W.; Tanokura, M.; Fukuda, H.; Kondo, Y.
10.1101/2021.01.19.427273 — developmental biology — Posted on 2021-01-20
1738 Large lakes harbor streamlined free-living nitrifiers
Podowski, J. C.; Paver, S. F.; Newton, R. J.; Coleman, M. L.
10.1101/2021.01.19.427344 — microbiology — Posted on 2021-01-20
1742 COVID-19 Knowledge, Attitudes, and Practices of United Arab Emirates Medical and Health Sciences Students: A Cross Sectional Study
Baniyas, N.; Sheek-Hussein, M. M.; Al Kaabi, N.; Al Shamsi, M.; Al Neyadi, M. M.; Al Khoori, R.; Ajab, S.; Abid, M.; Grivna, M.; Abu Zidan, F. M.
10.1101/2021.01.19.427250 — scientific communication and education — Posted on 2021-01-19
1750 SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients
Rosin, N. L.; Jaffer, A.; Sinha, S.; Mulloy, R. P.; Robinson, C.; Labit, E.; Almeida, L. G.; Dufour, A.; Corcoran, J. A.; Yipp, B.; Biernaskie, J.
10.1101/2021.01.19.427282 — immunology — Posted on 2021-01-19
1752 Autism Spectrum Disorder is a Risk Factor for PTSD-like Memory Formation
Al Abed, A. S.; Sellami, A.; Marighetto, A.; Desmedt, A.; Dehorter, N.
10.1101/2021.01.18.427217 — neuroscience — Posted on 2021-01-19
1756 Txikispora philomaios n. sp., n. g., a Micro-Eukaryotic Pathogen of Amphipods, Reveals Parasitism and Hidden Diversity in Class Filasterea
Urrutia, A.; Mitsi, K.; Foster, R.; Ross, S.; Carr, M.; Marigomez, I.; Leger, M. M.; Ruiz-Trillo, I.; Feist, S. W.; Bass, D.
10.1101/2021.01.19.427289 — pathology — Posted on 2021-01-19
1760 H2AFB1 is a cancer/testis gene involved in hyperactivation of ribosome biogenesis in Hodgkin Lymphoma
Tremethick, D.; Xuanzhao, J.; Wen, J. J.; Pavwer, E.; Yu-Huan, W.; Sun, G.; Pullman, A.; Dahlstrome, J. E.; Soboleva, T.
10.1101/2021.01.19.427265 — genomics — Posted on 2021-01-19
1767 BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2
Tian, R.; Samelson, A. J.; Rezelj, V. V.; Chen, M.; Ramadoss, G. N.; Guo, X.; Mac Kain, A.; Tran, Q. D.; Lim, S. A.; Lui, I.; Nunez, J.; Rockwood, S. J.; Liu, N.; Carlson-Stevermer, J.; Oki, J.; Maures, T.; Holden, K.; Weissman, J. S.; Wells, J. A.; Conklin, B.; Vignuzzi, M.; Kampmann, M.
10.1101/2021.01.19.427194 — cell biology — Posted on 2021-01-19
1768 The long non-coding RNA Pax6os1/PAX6-AS1 modulates pancreatic beta cell identity and function.
Lopez-Noriega, L.; Callingham, R. M.; Martinez-sanchez, A.; Pizza, G.; Haberman, N.; Cvetesic, N.; Nguyen-Tu, M.-S.; Lenhard, B.; Leclerc, I.; Marchetti, P.; Piemonti, L.; de Koning, E. J. P.; Shapiro, A. M. J.; Johnson, P. R.; Pullen, T. J.; Rutter, G. A.
10.1101/2020.07.17.209015 — cell biology — Posted on 2021-01-19
1769 Genetic, cellular and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
Trofimenko, E.; Grasso, G.; Heulot, M.; Chavalier, N.; Deriu, M. A.; Dubuis, G.; Arribat, Y.; Serulla, M.; Michel, S.; Vantomme, G.; Ory, F.; Dam, L. C.; Puyal, J. P.; Amati, F.; Luthi, A.; Danani, A.; Widmann, C.
10.1101/2020.02.25.963017 — cell biology — Posted on 2021-01-19
1773 A trans-complementation system for SARS-CoV-2
Zhang, X.; Liu, Y.; Liu, J.; Bailey, A. L.; Plante, K. S.; Plante, J. A.; Zou, J.; Xia, H.; Bopp, N. E.; Aguilar, P. V.; Ren, P.; Menachery, V. D.; Diamond, M. S.; Weaver, S. C.; Xie, X.; Shi, P.-Y.
10.1101/2021.01.16.426970 — microbiology — Posted on 2021-01-19
1775 Experimental re-infected cats do not transmit SARS-CoV-2
Gaudreault, N. N.; Carossino, M.; Morozov, I.; Trujillo, J. D.; Meekins, D. A.; Madden, D. W.; Cool, K.; Libanori Artiaga, B.; McDowell, C.; Bold, D.; Balaraman, V.; Kwon, T.; Ma, W.; Henningson, J.; Wilson, D. W.; Wilson, W. C.; Balasuriya, U. B.; Garcia-Sastre, A.; Richt, J. A.
10.1101/2021.01.18.427182 — microbiology — Posted on 2021-01-19
1777 The impact of Spike mutations on SARS-CoV-2 neutralization
Rees-Spear, C.; Muir, L.; Griffith, S. A.; Heaney, J.; Aldon, Y.; Snitselaar, J.; Thomas, P.; Graham, C.; Seow, J.; Lee, N.; Rosa, A.; Roustan, C.; Houlihan, C. F.; Sanders, R. W.; Gupta, R. K.; Cherepanov, P.; Stauss, H.; Nastouli, E.; Doores, K. J.; van Gils, M. J.; McCoy, L. E.
10.1101/2021.01.15.426849 — immunology — Posted on 2021-01-19
1778 Mitochondrial oxidative stress drives IL-12/IL-18-induced IFN-gamma production by CD4+ T cells and is controlled by Fas
Rackov, G.; Zaniani, P. T.; del Pino, S. C.; Shokri, R.; Mon, M. A.; Martinez-A, C.; Balomenos, D.
10.1101/2021.01.19.427239 — immunology — Posted on 2021-01-19
1779 Metabolic control of type 2 innate lymphoid cells plasticity toward protective type 1-like cells during Mycobacterium tuberculosis infection
Hudrisier, D.; Corral, D.; Charton, A.; Krauss, M. Z.; Blanquart, E.; Levillain, F.; Lefrancais, E.; Girard, J.-P.; Eberl, G.; Poquet, Y.; Guery, J.-C.; Arguello, R. J.; Hepworth, M. R.; Neyrolles, O.
10.1101/2021.01.19.427257 — immunology — Posted on 2021-01-19
1780 Hinge Influences in Murine IgG Binding to Cryptococcus neoformans Capsule
Oliveira, D. S. L. d.; Paredes, V.; Caixeta, A. V.; Henriques, N. M.; Wear, M. P.; Albuquerque, P.; Felipe, M. S. S.; Casadevall, A.; Nicola, A. M.
10.1101/2021.01.18.427174 — immunology — Posted on 2021-01-19
1784 Individual-Specific Areal-Level Parcellations Improve Functional Connectivity Prediction of Behavior
Kong, R.; Yang, Q.; Gordon, E.; Xue, A.; Yan, X.; Orban, C.; Zuo, X.-N.; Spreng, N.; Ge, T.; Holmes, A.; Eickhoff, S.; Yeo, B. T. T.
10.1101/2021.01.16.426943 — neuroscience — Posted on 2021-01-19
1788 All-optical electrophysiology in hiPSC-derived neurons with synthetic voltage sensors
Puppo, F.; Sadegh, S.; Trujillo, C.; Thunemann, M.; Campbell, E.; Vandenberghe, M.; Shan, X.; Akkouh, I. A.; Miller, E. W.; Bloodgood, B. L.; Silva, G. A.; Dale, A. M.; Einevoll, G. T.; Djurovic, S.; Andreassen, O. A.; Muotri, A. R.; Devor, A.
10.1101/2021.01.18.427081 — neuroscience — Posted on 2021-01-19
1789 The variability in potential biomarkers for cochlear synaptopathy after recreational noise exposure
Vande Maele, T.; Keshishzadeh, S.; De Poortere, N.; Dhooge, I.; Keppler, H.; Verhulst, S.
10.1101/2021.01.17.427007 — neuroscience — Posted on 2021-01-19
1790 Predicting genotype-specific gene regulatory networks
Weighill, D. A.; Ben Guebila, M.; Glass, K.; Quackenbush, J.; Platig, J.
10.1101/2021.01.18.427134 — systems biology — Posted on 2021-01-19
1793 Targeting EGFR in glioblastoma with a novel brain-penetrant small molecule EGFR-TKI
Ni, J.; Wang, Y.; Wang, Q.; Bergholz, J. S.; Jiang, T.; Roberts, T. M.; Gray, N. S.; Zhao, J. J.
10.1101/2021.01.09.426030 — cancer biology — Posted on 2021-01-19
1794 SRF-MYOCD axis is the targetable driver of a well differentiated aggressive subtype of leiomyosarcomas
Darbo, E.; Perot, G.; Darmusey, L.; Le Guellec, S.; Leroy, L.; Gaston, L.; Desplat, N.; Thebault, N.; Merle, C.; Rochaix, P.; Valentin, T.; Ferron, G.; Chevreau, C.; Bui, B.; Stoeckle, E.; Ranchere-Vince, D.; Meeus, P.; Terrier, P.; Piperno-Neumann, S.; Collin, F.; De Pinieux, G.; Duffaud, F.; Coindre, J.-M.; Blay, J.-Y.; Chibon, F.
10.1101/2020.10.23.352336 — cancer biology — Posted on 2021-01-19
1795 Somatic Mutations in Collagens are Associated with a Distinct Tumor Environment and Overall Survival in Gastric Cancer
Brodsky, A. S.; Khurana, J.; Guo, K.; Wu, E. Y.; Yang, D.; Wong, I. Y.; Uzun, E. D.; Resnick, M. B.
10.1101/2021.01.19.426938 — cancer biology — Posted on 2021-01-19
1797 An all-solid-state heterojunction oxide transistor for the rapid detection of biomolecules and SARS-CoV-2 spike S1 protein
Lin, Y.-H.; Han, Y.; Sharma, A.; AlGhamdi, W. S.; Liu, C.-H.; Chang, T.-H.; Xiao, X.-W.; Seitkhan, A.; Mottram, A. D.; Pattanasattayavong, P.; Faber, H.; Heeney, M.; Anthopoulos, T. D.
10.1101/2021.01.19.427256 — bioengineering — Posted on 2021-01-19
1800 SARS-CoV-2 Genomic Surveillance in Costa Rica: Evidence of a Divergent Population and an Increased Detection of a Spike T1117I Mutation
Molina Mora, J. A.; Cordero-Laurent, E.; Godinez, A.; Calderon-Osorno, M.; Brenes, H.; Soto-Garita, C.; Perez-Corrales, C.; COINGESA-CR Consorcio Interinstitucional de Estudios Genomicos del SARS-CoV-2 Costa Rica, ; Drexler, J. F.; Moreira-Soto, A.; Corrales-Aguilar, E.; Duarte-Martinez, F.
10.1101/2020.12.21.423850 — genomics — Posted on 2021-01-19
1802 The parasite Schistocephalus solidus secretes proteins with putative host manipulation functions
Berger, C. S.; Laroche, J.; Maaroufi, H.; Martin, H.; Moon, K.-M.; Landry, C.; Foster, L.; Aubin-Horth, N.
10.1101/2020.02.03.932509 — genomics — Posted on 2021-01-19
1803 Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions
Wan, Y.; Yang, S. L.; DeFalco, L.; Anderson, D. E.; Zhang, Y.; Aw, A. J.; Lim, S. Y.; Lim, X. N.; Tan, K. Y.; Zhang, T.; Chawla, T.; Su, Y.; Lezhava, A.; Sessions, P. d.; Merits, A.; Wang, L.-F.; Huber, R. G.
10.1101/2021.01.17.427000 — genomics — Posted on 2021-01-19
1805 Unravelling the genetic architecture of musical rhythm: a large-scale genome-wide association study of beat synchronization
Niarchou, M.; Gustavson, D. E.; Sathirapongsasuti, J. F.; Anglada-Tort, M.; Eising, E.; Bell, E.; McArthur, E.; Straub, P.; The 23andMe Research Team, ; McAuley, J. D.; Capra, J. A.; Ullen, F.; Creanza, N.; Mosing, M. A.; Hinds, D.; Davis, L. K.; Jacoby, N.; Gordon, R. L.
10.1101/836197 — genetics — Posted on 2021-01-19
1807 Paradoxes and synergies: optimizing management of a deadly virus in an endangered carnivore
Gilbertson, M. L. J.; Onorato, D.; Cunningham, M. W.; VandeWoude, S.; Craft, M. E.
10.1101/2021.01.11.426249 — ecology — Posted on 2021-01-19
1813 Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine
Watanabe, Y.; Mendonca, L.; Allen, E. R.; Howe, A.; Lee, M.; Allen, J. D.; Chawla, H.; Pulido, D.; Donnellan, F.; Davies, H.; Ulaszewska, M.; Belij-Rammerstorfer, S.; Morris, S.; Krebs, A.-S.; Dejnirattisai, W.; Mongkolsapaya, J.; Supasa, P.; Screaton, G. R.; Green, C. M.; Lambe, T.; Zhang, P.; Gilbert, S. C.; Crispin, M.
10.1101/2021.01.15.426463 — microbiology — Posted on 2021-01-19
1814 Rapid protection from COVID-19 in nonhuman primates vaccinated intramuscularly but not intranasally with a single dose of a recombinant vaccine
Furuyama, W.; Shifflett, K.; Pinksi, A. N.; Griffin, A. J.; Feldmann, F.; Okumura, A.; Gourdine, T.; Jankeel, A.; Lovaglio, J.; Hanley, P. W.; Thomas, T.; Clancy, C. S.; Messaoudi, I.; O'Donnell, K. L.; Marzi, A.
10.1101/2021.01.19.426885 — microbiology — Posted on 2021-01-19
1815 mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
Wang, Z.; Schmidt, F.; Weisblum, Y.; Muecksch, F.; Barnes, C. O.; Finkin, S.; Schaefer-Babajew, D.; Cipolla, M.; Gaebler, C.; Lieberman, J. A.; Yang, Z.; Abernathy, M. E.; Huey-Tubman, K. E.; Hurley, A.; Turroja, M.; West, K. A.; Gordon, K.; Millard, K. G.; Ramos, V.; Silva, J. D.; Xu, J.; Colbert, R. A.; Patel, R.; Dizon, J. P.; Unson-O'Brien, C.; Shimeliovich, I.; Gazumyan, A.; Caskey, M.; Bjorkman, P. J.; Casellas, R.; Hatziioannou, T.; Bieniasz, P. D.; Nussenzweig, M. C.
10.1101/2021.01.15.426911 — immunology — Posted on 2021-01-19
1816 Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine-elicited human sera
Muik, A.; Wallisch, A.-K.; Saenger, B.; Swanson, K. A.; Muehl, J.; Chen, W.; Cai, H.; Sarkar, R.; Tuereci, O.; Dormitzer, P. R.; Sahin, U.
10.1101/2021.01.18.426984 — immunology — Posted on 2021-01-19
1819 Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase - Design, synthesis and biological evaluation
Chandran, R.; Vijayan, D.; Reddy, E. K.; Kumar, M.; Kesavan, L.; Jacob, R.; Ayyiliyath, S.; Variyar, J.; Anwar, S.; Zhang, K.; Chittalakkottu, S.; Omkumar, R. V.
10.1101/2021.01.18.427058 — neuroscience — Posted on 2021-01-19
1822 VEGF-A/VEGFR-1: a painful astrocyte-mediated signaling blocked by the anti-VEGFR-1 mAb D16F7
Micheli, L.; Parisio, C.; Lucarini, E.; Vona, A.; Toti, A.; Pacini, A.; Mello, T.; Boccella, S.; Ricciardi, F.; Maione, S.; Graziani, G.; Lacal, P. M.; Failli, P.; Ghelardini, C.; Di Cesare Mannelli, L.
10.1101/2021.01.19.427244 — neuroscience — Posted on 2021-01-19
1825 Extinction of the Thylacine
Brook, B. W.; Sleightholme, S. R.; Campbell, C. R.; Jaric, I.; Buettel, J. C.
10.1101/2021.01.18.427214 — zoology — Posted on 2021-01-19
1826 A new family of structurally conserved fungal effectors displays epistatic interactions with plant resistance proteins
Lazar, N.; Mesarich, C. H.; Petit-Houdenot, Y.; Talbi, N.; Li de la Sierra-Gallay, I.; Zelie, E.; Blondeau, K.; Gracy, J.; Ollivier, B.; Blaise, F.; Rouxel, T.; Balesdent, M.-H.; Idnurm, A.; van Tilbeurgh, H.; Fudal, I.
10.1101/2020.12.17.423041 — plant biology — Posted on 2021-01-19
1827 Adipocyte deletion of the RNA binding protein HuR induces cardiac hypertrophy and fibrosis
Guarnieri, A. R.; Anthony, S. R.; Gozdiff, A.; Green, L. C.; Slone, S.; Nieman, M. L.; Alam, P.; Benoit, J. B.; Kanisicak, O.; Tranter, M.
10.1101/2021.01.19.425776 — physiology — Posted on 2021-01-19
1829 Defining the cell surface proteomic landscape of multiple myeloma reveals immunotherapeutic strategies and biomarkers of drug resistance
Ferguson, I. D.; Escobar, B. P.; Tuomivaara, S. T.; Lin, Y.-H. T.; Nix, M. A.; Leung, K. K.; Hale, M.; Choudhry, P.; Lopez-Girona, A.; Ramos, E.; Wong, S. W.; Wolf, J. L.; Martin, T. G.; Shah, N.; Vandenberg, S.; Prakash, S.; Besse, L.; Driessen, C.; Wells, J. A.; Wiita, A. P.
10.1101/2021.01.17.427038 — cancer biology — Posted on 2021-01-19
1830 Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics
George, B.; Mukundan, P. P.; Paul, A. M.; Amjesh, R.; Leitzel, K.; Ali, S. M.; Sandiford, O.; Lipton, A.; Rameshwar, P.; Hortobagyi, G. N.; Pillai, R. M.; Kumar, R.
10.1101/840975 — cancer biology — Posted on 2021-01-19
1833 LIQA: Long-read Isoform Quantification and Analysis
Hu, Y.; Fang, L.; Chen, X.; Zhong, J. F.; Li, M.; Wang, K.
10.1101/2020.09.09.289793 — bioinformatics — Posted on 2021-01-19
1839 Transmission of one predicts another: Apathogenic proxies for transmission dynamics of a fatal virus
Gilbertson, M. L. J.; Fountain-Jones, N. M.; Malmberg, J. L.; Gagne, R. B.; Lee, J. S.; Kraberger, S.; Kechejian, S.; Petch, R.; Chiu, E.; Onorato, D.; Cunningham, M. W.; Crooks, K. R.; Funk, W. C.; Carver, S.; VandeWoude, S.; VanderWaal, K.; Craft, M. E.
10.1101/2021.01.09.426055 — ecology — Posted on 2021-01-19
1841 ACVR1R206H increases osteogenic/ECM gene expression and impairs myofiber formation in human skeletal muscle stem cells
Barruet, E.; Garcia, S. M.; Wu, J.; Morales, B. M.; Tamaki, S.; Moody, T.; Pomerantz, J. H.; Hsiao, E. C.
10.1101/2021.01.18.427082 — cell biology — Posted on 2021-01-19
1842 SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
Wibmer, C. K.; Ayres, F.; Hermanus, T.; Madzivhandila, M.; Kgagudi, P.; Lambson, B. E.; Vermeulen, M.; van den Berg, K.; Rossouw, T.; Boswell, M.; Ueckermann, V.; Meiring, S.; von Gottberg, A.; Cohen, C.; Morris, L.; Bhiman, J. N.; Moore, P. L.
10.1101/2021.01.18.427166 — immunology — Posted on 2021-01-19
1843 FcγR responses to soluble immune complexes are governed by solubility and size
Chen, H.; Maul-Pavicic, A.; Holzer, M.; Salzer, U.; Chevalier, N.; Voll, R. E.; Hengel, H.; Kolb, P.
10.1101/2020.11.11.378232 — immunology — Posted on 2021-01-19
1849 Untargeted metabolomic analyses reveal the diversity and plasticity of the specialized metabolome in seeds of different Camelina sativa varieties
Boutet, S.; Barreda, L.; Perreau, F.; Mouille, G.; Delannoy, E.; Martin-Magniette, M.-L.; Monti, A.; Lepiniec, L.; Zanetti, F.; Corso, M.
10.1101/2021.01.18.427130 — plant biology — Posted on 2021-01-19
1851 Lipophilic Nanocrystal Prodrug-Release Defines the Extended Pharmacokinetic Profiles of a Year-Long Cabotegravir
Gauram, N.; McMillan, J. M.; Kumar, D.; Bade, A. N.; Pan, Q.; Kulkarni, T. A.; Li, W.; Smith, N. A.; Dyavar Shetty, B. L.; Sillman, B.; Szlachetka, A.; Edagwa, B. J.; Gendelman, H. E.; Alnouti, Y.
10.1101/2021.01.18.427147 — pharmacology and toxicology — Posted on 2021-01-19
1852 Ectopic FVIII expression and misfolding in hepatocytes as a potential cause of human hepatocellular carcinoma
Deng, R.; Kapelanski-Lamoureux, A.; Gao, Z.-h.; Lazaris, A.; Giles, L.; Malhotra, J.; Yong, J.; Metrakos, P.; Kaufman, R. J.
10.1101/2021.01.19.427220 — cancer biology — Posted on 2021-01-19
1853 UniverSC: a flexible cross-platform single-cell data processing pipeline
Kelly, S. T.; Battenberg, K.; Hetherington, N. A.; Hayashi, M.; Minoda, A.
10.1101/2021.01.19.427209 — bioinformatics — Posted on 2021-01-19
1859 Quantifying nanotherapeutics penetration using hydrogel based microsystem as a new 3D in-vitro platform
Goodarzi, S.; Prunet, A.; Rossetti, F.; Tillement, O.; Porcel, E.; Lacombe, S.; Wu, T.-D.; Guerquin-Kern, J.-L.; Delanoë-Ayari, H.; Lux, F.; Riviere, C.
10.1101/2021.01.17.427020 — bioengineering — Posted on 2021-01-19
1860 A nexus of intrinsic dynamics underlies translocase priming
Krisnamurthy, S.; Eleftheriadis, N.; Karathanou, K.; Smit, J. H.; Portaliou, A.; Chatzi, K. E.; Karamanou, S.; Bondar, A.-N.; Gouridis, G.; Economou, A.
10.1101/2021.01.18.427065 — biochemistry — Posted on 2021-01-19
1861 Enhancing top-down proteomics of brain tissue with FAIMS
Fulcher, J. M.; Makaju, A.; Moore, R. J.; Zhou, M.; Bennett, D. C.; De Jager, P. L.; Qian, W.-J.; Pasa-Tolic, L.; Petyuk, V. A.
10.1101/2021.01.18.427216 — biochemistry — Posted on 2021-01-19
1862 Splenic denervation attenuates repeated social defeat stress-induced T-lymphocyte inflammation
Elkhatib, S. K.; Moshfegh, C. M.; Watson, G. F.; Schwab, A. D.; Katsurada, K.; Patel, K. P.; Case, A. J.
10.1101/2021.01.16.426952 — animal behavior and cognition — Posted on 2021-01-19
1863 Simultaneous single cell measurements of intranuclear proteins and gene expression
Chung, H.; Parkhurst, C.; Magee, E. M.; Phillips, D.; Habibi, E.; Chen, F.; Yeung, B.; Waldman, J. A.; Artis, D.; Regev, A.
10.1101/2021.01.18.427139 — genomics — Posted on 2021-01-19
1864 Molecular programs of fibrotic change in aging human lung
Lee, J.; Islam, M. N.; Boostanpour, K.; Aran, D.; Christenson, S.; Matthay, M. A.; Eckalbar, W.; DePianto, D. J.; Arron, J. R.; Magee, L.; Bhattacharya, S.; Matsumoto, R.; Kubota, M.; Farber, D. L.; Bhattacharya, J.; Wolters, P. J.; Bhattacharya, M.
10.1101/2021.01.18.427195 — genomics — Posted on 2021-01-19
1867 Fundamental identifiability limits in molecular epidemiology
Louca, S.; McLaughlin, A.; MacPherson, A.; Joy, J. B.; Pennell, M. W.
10.1101/2021.01.18.427170 — evolutionary biology — Posted on 2021-01-19
1868 Structural and functional characterization of a putative de novo gene in Drosophila
Lange, A.; Patel, P. H.; Heames, B.; Damry, A. M.; Saenger, T.; Jackson, C. J.; Findlay, G. D.; Bornberg-Bauer, E.
10.1101/2021.01.18.427054 — evolutionary biology — Posted on 2021-01-19
1874 Universal DNA methylation age across mammalian tissues
Lu, A. T.; Fei, Z.; Haghani, A.; Robeck, T. R.; Zoller, J. A.; Li, C. Z.; Zhang, J.; Ablaeva, J.; Adams, D. M.; Almunia, J.; Ardehali, R.; Arneson, A.; Baker, C. S.; Belov, K.; Black, P.; Blumstein, D. T.; Bors, E. K.; Breeze, C. E.; Brooke, R. T.; Brown, J. L.; Caulton, A.; Cavin, J. M.; Chatzistamou, I.; Chen, H.; Chiavellini, P.; Choi, O.-W.; Clarke, S.; DeYoung, J.; Dold, C.; Emmons, C. K.; Emmrich, S.; Faulkes, C. G.; Ferguson, S. H.; Finno, C. J.; Gaillard, J.-M.; Garde, E.; Gladyshev, V. N.; Gorbunova, V.; Goya, R. G.; Grant, M. J.; Hales, E. N.; Hanson, M. B.; Haulena, M.; Hogan, A. N.
10.1101/2021.01.18.426733 — developmental biology — Posted on 2021-01-19
1876 Interaction Between Phosphoinositide 3-Kinase and the VDAC2 Channel Tethers Endosomes to Mitochondria and Promotes Endosome Maturation
Satoh, A. O.; Fujioka, Y.; Kashiwagi, S.; Yoshida, A.; Fujioka, M.; Sasajima, H.; Nanbo, A.; Amano, M.; Ohba, Y.
10.1101/2021.01.18.427063 — cell biology — Posted on 2021-01-19
1878 (p)ppGpp inhibits 70S ribosome formation in Staphylococcus aureus by impeding GTPase-ribosome interactions
Bennison, D. J.; Nakamoto, J. A.; Craggs, T. D.; Milon, P.; Rafferty, J. B.; Corrigan, R. M.
10.1101/2021.01.19.427108 — microbiology — Posted on 2021-01-19
1879 Xanthomonas transcriptome inside cauliflower hydathodes reveals bacterial virulencestrategies and physiological adaptation at early infection stages
Luneau, J. S.; Cerutti, A.; Roux, B.; Carrere, S.; Jardinaud, M.-F.; Gaillac, A.; Gris, C.; Lauber, E.; Berthome, R.; Arlat, M.; Boulanger, A.; Noel, L. D.
10.1101/2021.01.19.427230 — microbiology — Posted on 2021-01-19
1880 Loss of C3aR induces immune infiltration and inflammatory microbiota in a novel spontaneous model of colon cancer
Krieg, C.; Carloni, S.; Weber, L. M.; Fosso, B.; Hardiman, G.; Mileti, E.; El Aidy, S.; Marzano, M.; Pesole, G.; Asnicar, F.; Segata, N.; Robinson, M. D.; Guglietta, S.
10.1101/2021.01.18.426963 — immunology — Posted on 2021-01-19
1881 Potent but transient immunosuppression of T-cells is a general feature of erythroid progenitor cells
Grzywa, T. M.; Sosnowska, A.; Rydzynska, Z.; Lazniewski, M.; Plewczynski, D.; Klicka, K.; Malecka, M.; Rodziewicz-Lurzynska, A.; Ciepiela, O.; Justyniarska, M.; Pomper, P.; Grzybowski, M. M.; Blaszczyk, R.; Wegrzynowicz, M.; Tomaszewska, A.; Basak, G.; Golab, J.; Nowis, D.
10.1101/2021.01.18.427109 — immunology — Posted on 2021-01-19
1885 Human Neural Stem Cells Differentiate and Integrate, Innervating Implanted zQ175 Huntington's Disease Mouse Striatum
Thompson, L. M.; Holley, S. M.; Reidling, J. C.; Cepeda, C.; Lau, A.; Moore, C.; Orellana, I.; Fury, B.; Kopan, L.; Yeung, S.; Neel, M.; Coleal-Bergum, D.; Monuki, E.; K. Meshul, C.; Bauer, G.; Levine, M. S.
10.1101/2021.01.18.427078 — neuroscience — Posted on 2021-01-19
1886 The neuroprotective effects of Sonic hedgehog pathway agonist SAG in a rat model of neonatal stroke
Nguyen, V.; Chavali, M.; Larpthaveesarp, A.; Kodali, S.; Gonzalez, G.; Franklin, R.; Rowitch, D. H.; Gonzalez, F.
10.1101/2021.01.19.427193 — neuroscience — Posted on 2021-01-19
1887 Phenotyping in the era of genomics: MaTrics a digital character matrix to document mammalian phenotypic traits coded numerically
Stefen, C.; Wagner, F.; Asztalos, M.; Giere, P.; Grobe, P.; Hiller, M.; Hofmann, R.; Jaehde, M.; Laechele, U.; Lehmann, T.; Ortmann, S.; Peters, B.; Ruf, I.; Schiffmann, C.; Thier, N.; Unterhitzenberger, G.; Vogt, L.; Rudolf, M.; Wehner, P.; Stuckas, H.
10.1101/2021.01.17.426960 — zoology — Posted on 2021-01-19
1889 Brassinosteroid signaling component SlBES1 promotes tomato fruit softening through transcriptional repression of PMEU1
Liu, H.; Liu, L.; Liang, D.; Zhang, M.; Jia, C.; Qi, M.; Liu, Y.; Shao, Z.; Meng, F.; Hu, S.; Li, C.; Wang, Q.
10.1101/2021.01.18.427052 — plant biology — Posted on 2021-01-19
1890 Analysis of phloem trajectory links tissue maturation to cell specialization.
Roszak, P.; Heo, J.-o.; Blob, B.; Toyokura, K.; de Luis Balaguer, M. A.; Lau, W.; Hamey, F. K.; Cirrone, J.; Wang, X.; Ursache, R.; Tavares, H.; Verstaen, K.; Wendrich, J.; Melnyk, C. W.; Shasha, D.; Ahnert, S.; Saeys, Y.; De Rybel, B.; Heidstra, R.; Scheres, B.; Mähönen, A. P.; Gottgens, B.; Sozzani, R.; Birnbaum, K. D.; Helariutta, Y.
10.1101/2021.01.18.427084 — plant biology — Posted on 2021-01-19
1891 Coordinated action of RTBV and RTSV proteins suppress host RNA silencing machinery
Anand, A.; Pinninti, M.; Tripathi, A.; Mangrauthia, S. K.; Sanan-Mishra, N.
10.1101/2021.01.19.427099 — plant biology — Posted on 2021-01-19
1892 RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth
Noviello, C.; Kobon, K.; Delivry, L.; Guilbert, T.; Julienne, F.; Maire, P.; Randrianarison-Huetz, V.; Sotiropoulos, A.
10.1101/2021.01.18.426685 — physiology — Posted on 2021-01-19
1895 Dissecting the localization of Tilapia tilapinevirus in the brain of the experimentally infected Nile tilapia (Oreochromis niloticus)
Dinh-Hung, N.; Sangpo, P.; Kruangkum, T.; Kayansamruaj, P.; Rung-ruangkijkrai, T.; Senapin, S.; Rodkhum, C.; Dong, H. T.
10.1101/2021.01.19.427199 — pathology — Posted on 2021-01-19
1896 STING suppresses cancer pain via immune and neuronal modulation
Wang, K.; Donnelly, C. R.; Jiang, C.; Liao, Y.; Tao, X.; Bang, S.; Lee, M.; Hilton, M.; Ji, R. R.
10.1101/2021.01.18.426944 — cancer biology — Posted on 2021-01-19
1897 The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival
Dewaele, S.; Delhaye, L.; De Paepe, B.; De Bony, E.; De Wilde, J.; Vanderheyden, K.; Anckaert, J.; Yigit, N.; VandenEynde, E.; Nemati, F.; Decaudin, D.; Jochemsen, A.; Leucci, E.; Vandesompele, J.; Van Dorpe, J.; Marine, J.-C.; Van Coster, R.; Eyckerman, S.; Mestdagh, P.
10.1101/2021.01.18.427176 — cancer biology — Posted on 2021-01-19
1900 Python-Microscope: high performance control of arbitrarily complex and scalable bespoke microscopes
Susano Pinto, D. M. M. S.; Phillips, M. A.; Hall, N.; Mateos-Langerak, J.; Stoychev, D.; Pinto, T. S.; Booth, M. J.; Davis, I.; Dobbie, I. M.
10.1101/2021.01.18.427171 — biophysics — Posted on 2021-01-19
1901 Computational and experimental approaches to controlling bacterial microcompartment assembly
Li, Y.; Kennedy, N. W.; Li, S.; Mills, C. E.; Tullman-Ercek, D.; Olvera de la Cruz, M.
10.1101/2021.01.18.427120 — biophysics — Posted on 2021-01-19
1902 Microscope-Cockpit: Python-based bespoke microscopy for bio-medical science
Phillips, M. A.; Susano Pinto, D. M.; Hall, N.; Mateos-Langerak, J.; Parton, R. M.; Stoychev, D. V.; Park, T.; Pinto, T. S.; Sedat, J. W.; Booth, M. J.; Davis, I.; Dobbie, I. M.
10.1101/2021.01.18.427178 — biophysics — Posted on 2021-01-19
1904 Free energy and kinetics of cAMP permeation through connexin26 hemichannel with and without voltage
Jiang, W.; Lin, Y.-C.; Botello-Smith, W. M.; Contreras, J. E.; Harris, A.; Maragliano, L.; Luo, Y.
10.1101/2021.01.18.427208 — biophysics — Posted on 2021-01-19
1906 ExpertRNA: A new framework for RNA structure prediction
Liu, M.; Pedrielli, G.; Poppleton, E.; Sulc, P.; Bertsekas, D.
10.1101/2021.01.18.427087 — bioinformatics — Posted on 2021-01-19
1910 Polymeric assembly of endogenous Tuberous Sclerosis Protein Complex
Dai, D. L.; Hasan, S. M. N.; Woollard, G.; Bueler, S. A.; Julien, J.-P.; Rubinstein, J. L.; Mazhab-Jafari, M. T.
10.1101/2021.01.18.426261 — biochemistry — Posted on 2021-01-19
1912 A Chromosome-scale draft genome sequence of horsegram (Macrotyloma uniflorum)
Shirasawa, K.; Chahota, R.; Hirakawa, H.; Nagano, S.; Nagasaki, H.; Sharma, T. R.; Isobe, S.
10.1101/2021.01.18.427074 — genomics — Posted on 2021-01-19
1913 Transspecies beak color polymorphism in the Darwin's finch radiation
Enbody, E. D.; Sprehn, C. G.; Abzhanov, A.; Bi, H.; Dobreva, M. P.; Osborne, O.; Rubin, C.-J.; Grant, B. R.; Grant, P. R.; Andersson, L.
10.1101/2021.01.19.426595 — evolutionary biology — Posted on 2021-01-19
1915 Primer biases in the molecular assessment of diet in multiple insectivorous mammals
Browett, S. S.; Curran, T. G.; O'Meara, D. B.; Harrington, A. P.; Sales, N. G.; Antwis, R. E.; O'Neill, D.; McDevitt, A.
10.1101/2021.01.18.426998 — ecology — Posted on 2021-01-19
1920 Large field of view-spatially resolved transcriptomics at nanoscale resolution
Chen, A.; Liao, S.; cheng, M.; Ma, K.; Wu, L.; Lai, Y.; Yang, J.; Li, W.; Xu, J.; Hao, S.; Chen, X.; Liu, X.; Huang, X.; Lin, F.; Tang, X.; Li, Z.; Hong, Y.; Fu, D.; Jiang, Y.; Peng, J.; Liu, S.; Shen, M.; Liu, C.; Li, Q.; Wang, Z.; Wang, Z.; Huang, X.; Yuan, Y.; Volpe, G.; Ward, C.; Munoz-Canoves, P.; Thiery, J. P.; Zhao, F.; Li, M.; Kuang, H.; Wang, O.; Lu, H.; Wang, B.; Ni, M.; Zhang, W.; Mu, F.; Yin, Y.; Yang, H.; Lisby, M.; Cornall, R. J.; Uhlen, M.; Esteban, M. A.; Li, Y.; Liu, L.; Wang, J.; Xu, X.
10.1101/2021.01.17.427004 — cell biology — Posted on 2021-01-19
1921 PERK-dependent reciprocal crosstalk between ER and non-centrosomal microtubules coordinates ER architecture and cell shape
Sanchez-Alvarez, M.; Lolo, F. N.; Sailem, H.; Pascual-Vargas, P.; Fulgoni, G.; Arias-Garcia, M.; del Pozo, M. A.; Bakal, C.
10.1101/2021.01.19.426991 — cell biology — Posted on 2021-01-19
1922 Fluorescence-based 3D targeting of FIB-SEM acquisition of small volumes in large samples
Ronchi, P.; Machado, P.; D'Imprima, E.; Mizzon, G.; Best, B. T.; Cassella, L.; Schnorrenberg, S.; Montero, M. G.; Jechlinger, M.; Ephrussi, A.; Leptin, M.; Mahamid, J.; Schwab, Y.
10.1101/2021.01.18.427072 — cell biology — Posted on 2021-01-19
1923 The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo
Crispatzu, G.; Rehimi, R.; Pachano, T.; Bleckwehl, T.; de la Cruz Molina, S.; Xiao, C.; Mahabir-Brenner, E.; Bazzi, H.; Rada-Iglesias, A.
10.1101/2021.01.18.427085 — molecular biology — Posted on 2021-01-19
1924 Mobile microscopy and telemedicine platform assisted by deep learning for quantification of Trichuris trichiura infection.
Dacal, E.; Bermejo-Pelaez, D.; Lin, L.; Alamo, E.; Cuadrado, D.; Martinez, A.; Mousa, A.; Postigo, M.; Soto, A.; Sukosd, E.; Vladimirov, A.; Mwandawiro, C.; Gichuki, P.; Aba Williams, N.; Munoz, J.; Kepha, S.; Luengo-Oroz, M.
10.1101/2021.01.19.426683 — microbiology — Posted on 2021-01-19
1925 The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models
Davies, S. P.; Mycroft-West, C. J.; Pagani, I.; Hill, H. J.; Chen, Y.-H.; Karlsson, R. T.; Bagdonaite, I.; Guimond, S. E.; Stamataki, Z.; Lima, M. A.; Turnbull, J. E.; Yang, Z.; Vicenzi, E. E.; Skidmore, M. A.; Khanim, F.; Richardson, A.
10.1101/2021.01.10.426114 — pharmacology and toxicology — Posted on 2021-01-19
1929 Distinct Patterns of Emergence of SARS-CoV-2 Spike Variants including N501Y in Clinical Samples in Columbus Ohio
Tu, H.; Avenarius, M. R.; Kubatko, L.; Hunt, M.; Pan, X.; Ru, P.; Garee, J.; Thomas, K.; Mohler, P.; Pancholi, P.; Jones, D.
10.1101/2021.01.12.426407 — genomics — Posted on 2021-01-19
1930 Flexible multivariate linear mixed models for structured multiple traits
Kim, H.; Farage, G.; Lovell, J. T.; Mckay, J. K.; Juenger, T. E.; Sen, S.
10.1101/2020.03.27.012690 — genetics — Posted on 2021-01-19
1931 An evolutionary portrait of the progenitor SARS-CoV-2 and its dominant offshoots in COVID-19 pandemic
Kumar, S.; Tao, Q.; Weaver, S.; Sanderford, M. D.; Caraballo, M.; Sharma, S.; Kosakovsky Pond, S. L.; Miura, S.
10.1101/2020.09.24.311845 — evolutionary biology — Posted on 2021-01-19
1932 Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
McCarthy, K. R.; Rennick, L. J.; Nambulli, S.; Robinson-McCarthy, L. R.; Bain, W. G.; Haidar, G.; Duprex, W. P.
10.1101/2020.11.19.389916 — microbiology — Posted on 2021-01-19
1933 Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates
Zabaleta, N.; Dai, W.; Bhatt, U.; Chichester, J. A.; Sanmiguel, J.; Estelien, R.; Michalson, K. T.; Diop, C.; Maciorowski, D.; Qi, W.; Hudspeth, E.; Cucalon, A.; Dyer, C. D.; Pampena, M. B.; Knox, J. J.; LaRocque, R. C.; Charles, R. C.; Li, D.; Kim, M.; Sheridan, A.; Storm, N.; Johnson, R. I.; Feldman, J.; Hauser, B. M.; Zinn, E.; Ryan, A.; Kobayashi, D. T.; Chauhan, R.; McGlynn, M.; Ryan, E. T.; Schmidt, A. G.; Price, B.; Honko, A.; Griffiths, A.; Yaghmour, S.; Hodge, R.; Betts, M. R.; Freeman, M. W.; Wilson, J. M.; Vandenberghe, L. H.
10.1101/2021.01.05.422952 — immunology — Posted on 2021-01-19
1935 Intracranial electrical stimulation alters meso-scale network integration as a function of network topology
Thompson, W. H.; Esteban, O.; Oya, H.; Nair, R.; Eberhardt, F.; Dubois, J.; Poldrack, R. A.; Adolphs, R.; Shine, J. M.
10.1101/2021.01.16.426941 — neuroscience — Posted on 2021-01-19
1936 Cholinergic signalling in the forebrain controls microglial phenotype and responses to systemic inflammation
Nazmi, A.; Griffin, E. W.; Field, R. H.; Doyle, S.; Hennessy, E.; O'Donnell, M. M.; Rehill, A.; McCarthy, A.; Healy, D.; Doran, M. M.; Lowry, J. P.; Cunningham, C.
10.1101/2021.01.18.427123 — neuroscience — Posted on 2021-01-19
1938 Germline ERBB3 mutation in familial non-small cell lung carcinoma: expanding the role of the ErbB family in oncogenesis.
McInerney-Leo, A. M.; Chew, H. Y.; Inglis, P.-L.; Leo, P. J.; Joseph, S. R.; Cooper, C. L.; Okano, S.; Hassall, T.; Anderson, L.; Bowman, R. V.; Gattas, M.; Harris, J. E.; Marshall, M. S.; Shaw, J. G.; Wheeler, L.; Yang, I. A.; Brown, M. A.; Fong, K. M.; Simpson, F.; Duncan, E. L.
10.1101/2020.05.29.122796 — genomics — Posted on 2021-01-19
1942 In vivo structure and dynamics of the RNA genome of SARS-Cov-2
Zhang, Y.; Huang, K.; Xie, D.; Lau, J. Y.; Shen, W.; Li, P.; Wang, D.; Zou, Z.; Shi, S.; Ren, H.; Jin, M.; Kudla, G.; Zhao, Z.
10.1101/2021.01.15.426526 — genomics — Posted on 2021-01-19
1943 Emergence and Evolution of a Prevalent New SARS-CoV-2 Variant in the United States
Pater, A. A.; Bosmeny, M. S.; Barkau, C. L.; Ovington, K. N.; Chilamkurthy, R.; Parasrampuria, M.; Eddington, S. B.; Yinusa, A. O.; White, A. A.; Metz, P. E.; Sylvain, R. J.; Hebert, M. M.; Benzinger, S. W.; Sinha, K. T.; Gagnon, K. T.
10.1101/2021.01.11.426287 — genomics — Posted on 2021-01-19
1944 Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity
JIA, Y.; Shen, G.; Nguyen, S.; Zhang, Y.; Huang, K.-S.; Ho, H.-Y.; Hor, W.-S.; Yang, C.-H.; Bruning, J. B.; Li, C.; Wang, W.-L.
10.1101/2020.04.09.034942 — evolutionary biology — Posted on 2021-01-19
1945 Local Shape Descriptors for Neuron Segmentation
Sheridan, A.; Nguyen, T.; Deb, D.; Lee, W.-C. A.; Saalfeld, S.; Turaga, S.; Manor, U.; Funke, J.
10.1101/2021.01.18.427039 — neuroscience — Posted on 2021-01-19
1946 ComMet: A method for comparing metabolic states in genome-scale metabolic models
Sarathy, C.; Breuer, M.; Kutmon, M.; Adriaens, M. E.; Evelo, C. T.; Arts, I. C. W.
10.1101/2020.09.14.296145 — systems biology — Posted on 2021-01-19
1949 Tumor-Antagonizing Fibroblasts Secrete Prolargin as Tumor Suppressor in Hepatocellular Carcinoma
Chiavarina, B.; Ronca, R.; Otaka, Y.; Sutton, R. B.; Rezzola, S.; Yokobori, T.; Chiodelli, P.; Souche, R.; Maraver, A.; Faa, G.; Oyama, T.; Gofflot, S.; Bellahcene, A.; Detry, O.; Delvenne, P.; Castronovo, V.; Nishiyama, M.; Turtoi, A.
10.1101/2021.01.04.425182 — cancer biology — Posted on 2021-01-19
1956 The Amyloid Precursor Protein is a conserved Wnt receptor
Liu, T.; Nicolas, M.; Zhang, T.; Rice, H.; Soldano, A.; Claeys, A.; Petrova, I.; Fradkin, L.; De Strooper, B.; Hassan, B. A.
10.1101/2021.01.18.426557 — cell biology — Posted on 2021-01-18
1958 Histone Deacetylase 2 (HDAC2) influences maturation and mitochondrial dynamics in human induced pluripotent stem cell derived neurons.
Frankowski, H.; Yeboah, F.; Berry, B.; Kinoshita, C.; Lee, M.; Evitts, K.; Davis, J.; Kinoshita, Y.; Morrison, R. S.; Young, J. E.
10.1101/2021.01.18.427156 — neuroscience — Posted on 2021-01-18
1961 Less is more: a dose-response mechanistic account of intranasal oxytocin pharmacodynamics in the human brain
Martins, D.; Brodmann, K.; Veronese, M.; Dipasquale, O.; Mazibuko, N.; Schuschnig, U.; Zelaya, F.; Fotopoulou, K.; Paloyelis, Y.
10.1101/2021.01.18.427062 — neuroscience — Posted on 2021-01-18
1968 Cellular Fitness Phenotypes of Cancer Target Genes from On-cobiology to Cancer Therapeutics
George, B.; Mukundan, P. P.; Paul, A. M.; Leitzel, K.; Ali, S. M.; Sandiford, O.; Lipton, A.; Rameshwar, P.; Hortobagyi, G. N.; Pillai, R. M.; Kumar, R.
10.1101/840975 — cancer biology — Posted on 2021-01-18
1970 Effect of luminal surface structure of decellularized aorta on thrombus formation and cell behavior
Kobayashi, M.; Ohara, M.; Hashimoto, Y.; NAKAMURA, N.; Fujisato, T.; Kimura, T.; Kishida, A.
10.1101/2021.01.18.427096 — bioengineering — Posted on 2021-01-18
1971 Canopy spectral reflectance detects oak wilt at the landscape scale using phylogenetic discrimination
Sapes, G.; Lapadat, C.; Schweiger, A. K.; Juzwik, J.; Montgomery, R.; Gholizadeh, H.; Townsend, P. A.; Gamon, J.; Cavender-Bares, J.
10.1101/2021.01.17.427016 — ecology — Posted on 2021-01-18
1974 EEG in Motion: Using an Oddball Task to Explore Motor Interference in Active Skateboarding
Robles, D.; Kuziek, J. W. P.; Wlasitz, N. A.; Bartlett, N. T.; Hurd, P. L.; Mathewson, K. E.
10.1101/2020.06.08.136960 — neuroscience — Posted on 2021-01-18
1975 Evaluating features of scientific conferences: A call for improvements
Sarabipour, S.; Schwessinger, B.; Mumoki, F. N.; Mwakilili, A. D.; Khan, A.; Debat, H. J.; Saez, P.; Seah, S.; Mestrovic, T.
10.1101/2020.04.02.022079 — scientific communication and education — Posted on 2021-01-18
1979 Spontaneous selection of Cryptosporidium drug resistance in a calf model of infection
Hasan, M. M.; Stebbins, E. E.; Choy, R. K. M.; Gillespie, J. R.; de Hostos, E.; Miller, P. J.; Mushtaq, A.; Ranade, R. M.; Teixeira, J. E.; Verlinde, C. L. M. J.; Sateriale, A.; Zhang, Z.; Osbourn, D. M.; Griggs, D. W.; Fan, E.; Buckner, F. S.; Huston, C. D.
10.1101/2021.01.04.425361 — microbiology — Posted on 2021-01-18
1982 Mapping Brain-Behavior Space Relationships Along the Psychosis Spectrum
Ji, J. L.; Helmer, M.; Fonteneau, C.; Burt, J. B.; Tamayo, Z.; Demsar, J.; Adkinson, B.; Savic, A.; Preller, K.; Moujaes, F.; Vollenweider, F. X.; Martin, W.; Repovs, G.; Murray, J. D.; Anticevic, A.
10.1101/2020.09.15.267310 — neuroscience — Posted on 2021-01-18
1983 Sequential and efficient neural-population coding of complex task information
Koay, S. A.; Charles, A. S.; Thiberge, S. Y.; Brody, C.; Tank, D. W.
10.1101/801654 — neuroscience — Posted on 2021-01-18
1984 The human ApoE4 variant reduces functional recovery and neuronal sprouting after incomplete spinal cord injury in male mice
Toro, C. A.; Hansen, J.; Siddiq, M. M.; Johnson, K.; Zhao, W.; Azulai, D.; Das, D. K.; Bauman, W.; Sebra, R.; Cai, D.; Iyengar, R.; Cardozo, C. P.
10.1101/2020.11.05.369900 — neuroscience — Posted on 2021-01-18
1987 DProj: A toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images.
Herbert, S.; Valon, L.; Mancini, L.; Dray, N.; Caldarelli, P.; Gros, J.; Esposito, E.; Shorte, S. L.; Bally-Cuif, L.; Levayer, R.; Aulner, N.; Tinevez, J.-Y.
10.1101/2021.01.15.426809 — bioinformatics — Posted on 2021-01-18
1988 ORFik: a comprehensive R toolkit for the analysis of translation
Tjeldnes, H.; Labun, K.; Torres Cleuren, Y. N.; Chyzynyska, K.; Swirski, M.; Valen, E.
10.1101/2021.01.16.426936 — bioinformatics — Posted on 2021-01-18
1992 Invasion and maintenance of meiotic drivers in populations of ascomycete fungi
martinossi, i.; Veller, C.; Ament-Velasquez, S. L.; Vogan, A.; Rueffler, C.; Johannesson, H.
10.1101/2020.04.06.026989 — evolutionary biology — Posted on 2021-01-18
1993 A burning question: Can savannah fire management generate enough carbon revenue to help save the lion from extinction?
Tear, T.; Wolff, N. H.; Lipsett-Moore, G. L.; Ritchie, M. E.; Ribeiro, N. S.; Petracca, L. S.; Lindsey, P. A.; Hunter, L.; Loveridge, A. J.; Steinbruch, F.
10.1101/2020.06.04.132084 — ecology — Posted on 2021-01-18
1996 Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
Teano, G.; Concia, L.; Carron, L.; Wolff, L.; Adamusova, K.; Fojtova, M.; Bourge, M.; Kramdi, A.; Colot, V.; Grossniklaus, U.; Bowler, C.; Baroux, C.; Carbonne, A.; Probst, A. V.; Prochazkova Schrumpfova, P.; Fajkus, J.; Amiard, S.; Grob, S.; Bourbousse, C.; Barneche, F.
10.1101/2020.11.28.402172 — molecular biology — Posted on 2021-01-18
1998 A genomic perspective on genome size distribution across Earth's microbiomes reveals a tendency to gene loss
Rodriguez-Gijon, A.; Nuy, J. K.; Mehrshad, M.; Buck, M.; Schulz, F.; Woyke, T.; Garcia, S. L.
10.1101/2021.01.18.427069 — microbiology — Posted on 2021-01-18
1999 Selenium-dependent metabolic reprogramming during inflammation and resolution
Korwar, A. M.; Hossain, A.; Lee, T.-J.; Shay, A. E.; Basrur, V.; Conlon, K. P.; Smith, P. B.; Carlson, B. A.; Salis, H. M.; Patterson, A. D.; Prabhu, K. S.
10.1101/2021.01.16.426951 — immunology — Posted on 2021-01-18
2003 Forebrain Shh overexpression improves cognitive function in a Down syndrome mouse model and euploid littermates
Gao, F. J.; Klinedinst, D.; Cheng, B.; Savonenko, A.; Devenney, B.; Li, Y.; Wu, D.; Pomper, M. G.; Reeves, R. H.
10.1101/2021.01.18.427185 — neuroscience — Posted on 2021-01-18
2007 The viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
Vandermeulen, C.; O'Grady, T.; Galvan, B.; Cherkaoui, M.; Desbuleux, A.; Coppin, G.; Olivet, J.; Ben Ameur, L.; Kataoka, K.; Ogawa, S.; Thiry, M.; Mortreux, F.; Calderwood, M.; Hill, D. E.; Van Weyenbergh, J.; Charloteaux, B.; Vidal, M.; Dequiedt, F.; Twizere, J.-C.
10.1101/2021.01.18.427104 — systems biology — Posted on 2021-01-18
2008 Crosstalk between H2A variant-specific modifications impacts vital cell functions
Schmuecker, A.; Lei, B.; Lorkovic, Z.; Capella, M.; Braun, S. J.; Bourguet, P.; Mathieu, O.; Mechtler, K.; Berger, F.
10.1101/2021.01.14.426637 — synthetic biology — Posted on 2021-01-18
2010 Heterozygous mutation of Vegfr3 decreases renal lymphatics but is dispensable for renal function
Liu, H.; Hiremath, C.; Patterson, Q.; Vora, S.; Shang, Z.; Jamieson, A. R.; Fiolka, R. P.; Dean, K. M.; Dellinger, M. T.; Marciano, D. K.
10.1101/2021.01.17.427041 — physiology — Posted on 2021-01-18
2013 COMPARE, an ultra-fast and robust suite for multiparametric screening, identifies phenotypic drug responses in acute myeloid leukemia
Chalabi Hajkarim, M.; Karjalainen, E.; Osipovitch, M.; Dimopoulos, K.; Gordon, S. L.; Ambri, F.; Rasmussen, K. D.; Gronbaek, K.; Helin, K.; Wennerberg, K.; Won, K. J.
10.1101/2021.01.08.425880 — cancer biology — Posted on 2021-01-18
2018 Large scale genomic and evolutionary study reveals SARS-CoV-2 virus isolates from Bangladesh strongly correlate with European origin and not with China.
Rabbi, M. F. A.; Khan, M. I.; Hasan, S.; Chalita, M.; Hasan, K. N.; Sufian, A.; Hosen, M. B.; Polol, M. N. I.; Naima, J.; Lee, K.; Kim, Y. O.; Razu, M. H.; Khan, M.; Rahman, M. M.; Chun, J.; Khaleque, M. A.; Hasan, N. A.; Colwell, R. R.; Akhteruzzaman, S.
10.1101/2021.01.17.425424 — genetics — Posted on 2021-01-18
2020 CRISPR Del/Rei: A simple, flexible and efficient pipeline for scarless genome editing
Wahbeh, M. H.; Feuer, K. L.; Abdollahi, S.; Yovo, C.; Rabie, E.; Lam, A.-T.; Young, L.; Avramopoulos, D.
10.1101/2021.01.18.427163 — genetics — Posted on 2021-01-18
2021 Evaluating and integrating spatial capture-recapture models with data of variable individual identifiability
Ruprecht, J.; Eriksson, C.; Forrester, T. D.; Clark, D. A.; Wisdom, M.; Rowland, M. M.; Johnson, B. K.; Levi, T.
10.1101/2020.03.27.010850 — ecology — Posted on 2021-01-18
2022 Canopy spectral reflectance detects oak wilt at the landscape scale using phylogenetic discrimination
Sapes, G.; Lapadat, C.; Schweiger, A. K.; Juzwik, J.; Montgomery, R.; Gholizadeh, H.; Townsend, P. A.; Gamon, J.; Cavender-Bares, J.
10.1101/2021.01.17.427016 — ecology — Posted on 2021-01-18
2025 Metagenomic methylation patterns resolve complex microbial genomes
Wilbanks, E. G.; Dore, H.; Ashby, M. H.; Heiner, C.; Roberts, R. J.; Eisen, J. A.
10.1101/2021.01.18.427177 — microbiology — Posted on 2021-01-18
2027 Homo-and heterofermentative lactobacilli are differently affected by lignocellulosic inhibitory compounds
Giacon, T. G.; Cunha, G. C. d. G. e.; Elidorio, K. P.; Oliveira, R. P. d. S.; Basso, T. O.
10.1101/2021.01.18.427060 — microbiology — Posted on 2021-01-18
2031 A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging
Soch, J.; Richter, A.; Schütze, H.; Kizilirmak, J. M.; Assmann, A.; Feldhoff, H.; Fischer, L.; Heil, J.; Knopf, L.; Merkel, C.; Raschick, M.; Schietke, C. J.; Schult, A.; Yakupov, R.; Ziegler, G.; Wiltfang, J.; Düzel, E.; Schott, B. H.
10.1101/2021.01.16.426666 — neuroscience — Posted on 2021-01-18
2033 Eye movements elevate crowding in congenital idiopathic nystagmus
Tailor, V. K.; Theodorou, M.; Dahlmann-Noor, A. H.; Dekker, T. M.; Greenwood, J. A.
10.1101/2021.01.16.426927 — neuroscience — Posted on 2021-01-18
2034 Highly efficient multiplex editing: One-shot generation of 8x Nicotiana benthamiana and 12x Arabidopsis mutants
Stuttmann, J.; Barthel, K.; Martin, P.; Ordon, J.; Erickson, J. L.; Herr, R.; Ferik, F.; Kretschmer, C.; Berner, T.; Keilwagen, J.; Marillonnet, S.; Bonas, U.
10.1101/2020.03.31.018671 — plant biology — Posted on 2021-01-18
2036 Enhanced CICR activity reduces ER Ca2+ level in cells expressing CPVT-linked mutant RyR2
Kurebayashi, N.; Murayama, T.; Ohta, R.; Suzuki, J.; Kanemaru, K.; Ohno, S.; Horie, M.; Iino, M.; Yamashita, F.; Sakurai, T.
10.1101/2021.01.16.426980 — physiology — Posted on 2021-01-18
2037 The Mitochondrial Calcium Uniporter of Pulmonary Type 2 Cells Determines Severity of ARDS
Islam, M. N.; Gusarova, G. A.; Das, S. R.; Li, L.; Monma, E.; Anjaneyulu, M.; Owusu-Ansah, E.; Bhattacharya, S.; Bhattacharya, J.
10.1101/2021.01.18.427173 — physiology — Posted on 2021-01-18
2039 From COVID-19 to the Common Cold: Novel Host-Targeted, Pan-Respiratory Antiviral Small Molecule Therapeutics
Selvarajah, S.; Lingappa, A. F.; Michon, M.; Yu, S. F.; Macieik, A.; Mallesh, S.; Appiah, U.; Crabtree, J.; Copeland, K.; Lin, J.; Akintunde, O.; Nichols, C.; Petrouski, E.; Moreira, A. R.; Jiang, I.-t.; DeYarman, N.; Broce, S.; Brown, I.; Lau, S.; Segal, I.; Goldsmith, D.; Hong, S.; Asundi, V.; Briggs, E. M.; Phyo, N. S.; Froehlich, M.; Hogan, R. J.; Tripp, R. A.; Anand, S.; Campi, T. W.; Ford, M.; Reed, J. C.; Onisko, B.; Matlack, K.; Dey, D.; Lingappa, J. R.; Prasad, M. D.; Kitaygorodskyy, A.; Solas, D.; Paulvannan, K.; Lingappa, V. R.
10.1101/2021.01.17.426875 — biochemistry — Posted on 2021-01-18
2040 Geographical and environmental contributions to genomic divergence in mangrove forests
Silva, M. F. d.; Cruz, M. V.; Junior, J. d. D. V.; Zucchi, M. I.; Mori, G. M.; de Souza, A. P.
10.1101/2020.01.08.889717 — evolutionary biology — Posted on 2021-01-18
2042 Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes
Andrews, M. G.; Mukhtar, T.; Eze, U. C.; Simoneau, C. R.; Perez, Y.; Mostajo-Radji, M. A.; Wang, S.; Velmeshev, D.; Salma, J.; Kumar, G. R.; Pollen, A. A.; Crouch, E. E.; Ott, M.; Kriegstein, A. R.
10.1101/2021.01.17.427024 — neuroscience — Posted on 2021-01-18
2044 SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy
Lee, T.-H.; Wu, D.; Guzy, R.; Schoettler, N.; Adegunsoye, A.; Mueller, J.; Hussein, A.; Sperling, A.; Mutlu, G. M.; Fang, Y.
10.1101/2021.01.15.426691 — pathology — Posted on 2021-01-18
2049 Fishing for survival: importance of shark fisheries for the livelihoods of coastal communities in Western Ghana
Seidu, I.; Brobbey, L. K.; Danquah, E.; Oppong, S. K.; Beuningen, D. v.; Seidu, M.; Dulvy, N. K.
10.1101/2021.01.18.427106 — zoology — Posted on 2021-01-18
2054 Molecular basis of ligand recognition and activation of human V2 vasopressin receptor
Jiang, Y.; Zhou, F.; Ye, C.; Ma, X.; Yin, W.; Zhou, Q.; He, X.; Zhang, X.; Croll, T. I.; Yang, D.; Wang, P.; Xu, H. E.; Wang, M.-W.
10.1101/2021.01.18.427077 — biophysics — Posted on 2021-01-18
2056 AsmMix: A pipeline for high quality diploid denovo assembly
Wu, P.; Liu, C.; Wang, O.; Xia, Z.; Chen, F.; Chen, X.; Zhu, H.
10.1101/2021.01.15.426893 — genomics — Posted on 2021-01-18
2059 Spontaneous thought and microstate activity modulation by social imitation
Tomescu, M. I.; Papasteri, C. C.; Sofonea, A.; Boldasu, R.; Kebets, V.; Poalelungi, C.; Podina, I. R.; Nedelcea, C. I.; Berceanu, A. I.; Carcea, I.
10.1101/2021.01.15.426876 — neuroscience — Posted on 2021-01-18
2066 Dissociation of task engagement and arousal effects in auditory cortex and midbrain
Saderi, D.; Schwartz, Z. P.; Heller, C. R.; Pennington, J. R.; David, S. V.
10.1101/2020.06.16.155432 — neuroscience — Posted on 2021-01-18
2067 Human induced pluripotent stem cell-derived vessels as dynamic atherosclerosis model on a chip
Mallone, A.; Gericke, C.; Hosseini, V.; Chahbi, K.; Haenseler, W.; Emmert, M. Y.; Eckardstein, A. v.; Walther, J. H.; Vogel, V.; Weber, B.; Hoerstrup, S. P.
10.1101/2020.11.27.401034 — bioengineering — Posted on 2021-01-18
2072 Allosteric activation of T-cell antigen receptor signalling by quaternary structure relaxation
Lanz, A.-L.; Masi, G.; Porciello, N.; Cohnen, A.; Cipria, D.; Prakaash, D.; Balint, S.; Raggiaschi, R.; Galgano, D.; Cole, D.; Lepore, M.; Dushek, O.; Dustin, M.; Sansom, M.; Kalli, A. C.; Acuto, O.
10.1101/2020.12.02.407882 — immunology — Posted on 2021-01-18
2073 Hierarchy-guided Neural Networks for Species Classification
Elhamod, M.; Diamond, K. M.; Maga, A. M.; Bakis, Y.; Bart, H. L.; Mabee, P.; Dahdul, W.; Leipzig, J.; Greenberg, J.; Avants, B.; Karpatne, A.
10.1101/2021.01.17.427006 — evolutionary biology — Posted on 2021-01-18
2074 noisyR: Enhancing biological signal in sequencing datasets by characterising random technical noise
Moutsopoulos, I.; Maischak, L.; Lauzikaite, E.; Vasquez Urbina, S. A.; Williams, E. C.; Drost, H. G.; Mohorianu, I. I.
10.1101/2021.01.17.427026 — bioinformatics — Posted on 2021-01-18
2076 Model-based prediction of muscarinic receptor function from auditory mismatch negativity responses
Schöbi, D.; Jung, F.; Frässle, S.; Endepols, H.; Moran, R. J.; Friston, K. J.; Tittgemeyer, M.; Heinzle, J.; Stephan, K. E.
10.1101/2020.06.08.139550 — neuroscience — Posted on 2021-01-18
2077 Quantitative 3D microscopy reveals a genetic network predicting the local activity of anti-Aβ compounds
Kirschenbaum, D.; Voigt, F.; Dadgar-Kiani, E.; Catto, F.; Trevisan, C.; Bichsel, O.; Shirani, H.; Nilsson, P. K. R.; Frontzek, K.; Paganetti, P.; Helmchen, F.; Lee, J. H.; Aguzzi, A.
10.1101/2021.01.15.426090 — neuroscience — Posted on 2021-01-18
2080 NyuWa Genome Resource: Deep Whole Genome Sequencing Based Chinese Population Variation Profile and Reference Panel
Zhang, P.; Luo, H.; Li, Y.; Wang, Y.; Wang, J.; Zheng, Y.; Niu, Y.; Shi, Y.; Zhou, H.; Song, T.; Kang, Q.; Xu, T.; He, S.
10.1101/2020.11.10.376574 — genomics — Posted on 2021-01-18
2082 Quantifying Climatic and Socio-Economic Influences on Urban Malaria in Surat, India: A Modelling Study
Santos-Vega, M.; Lowe, R.; Anselin, L.; Desai, V.; Vaishnav, K. G.; Naik, A.; Pascual, M.
10.1101/583880 — ecology — Posted on 2021-01-18
2083 Beyond taxonomic identification: integration of ecological responses to a soil bacterial 16S rRNA gene database.
Jones, B. A.; Goodall, T.; George, P.; Gweon, H. s.; Puissant, J.; Read, D.; Emmett, B.; Robinson, D.; Jones, D.; Griffiths, R.
10.1101/843847 — microbiology — Posted on 2021-01-18
2084 Oocyte spindle assembly depends on multiple interactions between HP1 and the CPC
Wang, L.-I.; Defosse, T.; Jang, J. K.; Battaglia, R.; Wagner, V.; McKim, K.
10.1101/2020.06.03.132142 — genetics — Posted on 2021-01-17
2088 Inhibition of mitochondrial dynamics preferentially targets pancreatic cancer cells with enhanced tumorigenic and invasive potential
Courtois, S.; de Luxan-Delgado, B.; Penin-Peyta, L.; Royo-Garcia, A.; Parejo-Alonso, B.; Jagust, P.; Alcala, S.; Rubiolo, J. A.; Sanchez, L.; Sainz, B.; Heeschen, C.; Sancho, P.
10.1101/2021.01.17.426987 — cancer biology — Posted on 2021-01-17
2089 Cross-tissue single-cell transcriptomics reveals organizing principles of fibroblasts in health and disease
Buechler, M. B.; Pradhan, R. N.; Karabacak Calviello, A.; Muller, S.; Bourgon, R.; Turley, S. J.
10.1101/2021.01.15.426912 — genomics — Posted on 2021-01-17
2092 FiCoS: a fine- and coarse-grained GPU-powered deterministic simulator for biochemical networks
Tangherloni, A.; Nobile, M. S.; Cazzaniga, P.; Capitoli, G.; Spolaor, S.; Rundo, L.; Mauri, G.; Besozzi, D.
10.1101/2021.01.15.426855 — systems biology — Posted on 2021-01-17
2093 Targeting primary and metastatic uveal melanoma with a G protein inhibitor
Onken, M. D.; Makepeace, C. M.; Kaltenbronn, K. M.; Choi, J.; Hernandez-Aya, L.; Weilbaecher, K. N.; Piggott, K. D.; Rao, P. K.; Yuede, C. M.; Dixon, A. J.; Osei-Owusu, P.; Cooper, J. A.; Blumer, K. J.
10.1101/2021.01.16.426957 — cancer biology — Posted on 2021-01-17
2099 Fibrin is a critical regulator of neutrophil effector function at mucosal barrier sites
Silva, L. M.; Doyle, A. D.; Tran, C. L.; Greenwell-Wild, T.; Dutzan, N.; Lum, A. G.; Agler, C. S.; Sibree, M.; Jani, P.; Martin, D.; Kram, V.; Castellino, F. J.; Flick, M. J.; Divaris, K.; Bugge, T. H.; Moutsopoulos, N. M.
10.1101/2021.01.15.426743 — immunology — Posted on 2021-01-17
2100 Optimized CRISPR-mediated gene knock-in reveals FOXP3-independent control of human Treg identity
Lam, A. J.; Lin, D. T. S.; Gillies, J. K.; Uday, P.; Pesenacker, A. M.; Kobor, M. S.; Levings, M. K.
10.1101/2021.01.16.426937 — immunology — Posted on 2021-01-17
2105 Traumatic Brain Injury Impairs Systemic Vascular Function Through Altered Lipid Metabolism and Disruption of Inward-Rectifier Potassium (Kir2.1) Channels
Sackheim, A. M.; Villalba, N.; Sancho, M.; Harraz, O. F.; Bonev, A. D.; D'Alessandro, A.; Nemkov, T.; Nelson, M. T.; Freeman, K.
10.1101/2021.01.15.426853 — physiology — Posted on 2021-01-17
2106 Genetic analysis of the contribution of the proprotein convertases to the in vivo regulation of FGF23
Al Rifai, O.; Susan-Resiga, D.; Essalmani, R.; Creemers, J.; Seidah, N. G.; Ferron, M.
10.1101/2021.01.15.426882 — physiology — Posted on 2021-01-17
2108 Real-Time, Direct Classification of Nanopore Signals with SquiggleNet
Bao, Y.; Wadden, J.; Erb-Downward, J. R.; Ranjan, P.; Dickson, R. P.; Blaauw, D.; Welch, J. D.
10.1101/2021.01.15.426907 — bioinformatics — Posted on 2021-01-17
2110 The GA4GH Variation Representation Specification (VRS): a Computational Framework for the Precise Representation and Federated Identification of Molecular Variation
Wagner, A. H.; Babb, L.; Alterovitz, G.; Baudis, M.; Brush, M.; Cameron, D. L.; Cline, M.; Griffith, M.; Griffith, O.; Hunt, S.; Kreda, D.; Lee, J.; Lopez, J.; Moyer, E.; Nelson, T.; Patel, R. Y.; Riehle, K.; Robinson, P. N.; Rynearson, S.; Schuilenburg, H.; Tsukanov, K.; Walsh, B.; Konopko, M.; Rehm, H.; Yates, A. D.; Freimuth, R. R.; Hart, R. K.
10.1101/2021.01.15.426843 — bioinformatics — Posted on 2021-01-17
2116 Pathological turret mutations in the cardiac sodium channel cause long-range pore disruption
Habib, Z. F.; Kohli, M.; Salvage, S. C.; Rahman, T.; Huang, C. L.-H.; Jackson, A. P.
10.1101/2021.01.15.426807 — biochemistry — Posted on 2021-01-17
2120 Chromosome size affects sequence divergence between species through the interplay of recombination and selection
Tigano, A.; Khan, R.; Omer, A. D.; Weisz, D.; Dudchenko, O.; Multani, A. S.; Pathak, S.; Behringer, R. D.; Aiden, E. L.; Fisher, H.; MacManes, M. D.
10.1101/2021.01.15.426870 — evolutionary biology — Posted on 2021-01-17
2122 Sporulation is dispensable for the vegetable-associated life cycle of the human pathogen Bacillus cereus
Antequera-Gomez, M. L.; Diaz-Martinez, L.; Guadix, J. A.; Sanchez-Tevar, A. M.; Sopena-Torres, S.; Hierrezuelo, J.; Doan, H. K.; Leveau, J. H. J.; de Vicente, A.; Romero, D.
10.1101/2021.01.15.426836 — ecology — Posted on 2021-01-17
2123 The dynamic trophic architecture of open-ocean protist communities revealed through machine- guided metatranscriptomics
Lambert, B.; Groussman, R.; Schatz, M.; Coesel, S.; Durham, B.; Alverson, A. J.; White, A. E.; Armbrust, E. V.
10.1101/2021.01.15.426851 — ecology — Posted on 2021-01-17
2128 Human antibody immune responses are personalized by selective removal of MHC-II peptide epitopes
Gutierrez-Gonzalez, M.; Fahad, A. S.; Ardito, M.; Nanaware, P.; Lu, L.; Normandin, E.; Madan, B.; Tivin, J.; Coates, E.; Henry, A. R.; Laboune, F.; Graham, B. S.; Douek, D. C.; Ledgerwood, J. E.; Mascola, J. R.; Martin, W. D.; Stern, L.; De Groot, A. S.; DeKosky, B. J.
10.1101/2021.01.15.426750 — immunology — Posted on 2021-01-17
2130 The sensitivity of ECG contamination to surgical implantation site in adaptive closed-loop neurostimulation systems
Neumann, W.-J.; Memarian Sorkhabi, M.; Benjaber, M.; Feldmann, L. K.; Saryyeva, A.; Krauss, J. K.; Sieger, T.; Jech, R.; Contarino, M. F.; Tinkhauser, G.; Pollo, C.; Palmisano, C.; Isaias, I. U.; Cummins, D.; Little, S. J.; Starr, P. A.; Kokkinos, V.; Schneider, G.-H.; Herrington, T.; Brown, P.; Richardson, R. M.; Kuehn, A. A.; Denison, T.
10.1101/2021.01.15.426827 — neuroscience — Posted on 2021-01-17
2131 The impact of artifact removal approaches on TMS-EEG signal
Bertazzoli, G.; Esposito, R.; Mutanen, T. P.; Ferrari, C.; Ilmoniemi, R. J.; Miniussi, C.; Bortoletto, M.
10.1101/2021.01.15.426817 — neuroscience — Posted on 2021-01-17
2132 Association of a common genetic variant with Parkinson's disease is propagated through microglia
Langston, R.; Beilina, A.; Reed, X.; Singleton, A.; Blauwendraat, C.; Gibbs, J. R.; Cookson, M. R.
10.1101/2021.01.15.426824 — neuroscience — Posted on 2021-01-17
2134 High-density Neural Recordings from Feline Sacral Dorsal Root Ganglia with Thin-film Array
Sperry, Z. J.; Na, K.; Jun, J.; Madden, L. R.; Socha, A.; Yoon, E.; Seymour, J. P.; Bruns, T. M.
10.1101/2020.07.14.199653 — bioengineering — Posted on 2021-01-17
2136 GAD65Cre drives reporter expression in multiple taste cell types
Larson, E. D.; Vandenbeuch, A.; Anderson, C. B.; Kinnamon, S. C.
10.1101/2021.01.14.426727 — neuroscience — Posted on 2021-01-17
2139 Porcine pancreatic ductal epithelial cells transformed with KRASG12D and SV40T are tumorigenic
Bailey, K.; Cartwright, S. B.; Patel, N. S.; Remmers, N.; Lazenby, A. J.; Hollingsworth, M. A.; Carlson, M. A.
10.1101/2021.01.15.425792 — cancer biology — Posted on 2021-01-17
2140 Chitinase 3-like-1 Stimulates PD-L1 and Other Immune Checkpoint Inhibitors
Ma, B.; Akosman, B.; Kamle, S.; Lee, C.-M.; Koo, J. S.; Lee, C. G.; Elias, J. A.
10.1101/2021.01.15.426788 — cancer biology — Posted on 2021-01-17
2141 DProj: A toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images.
Herbert, S.; Valon, L.; Mancini, L.; Dray, N.; Caldarelli, P.; Gros, J.; Esposito, E.; Shorte, S. L.; Bally-Cuif, L.; Levayer, R.; Aulner, N.; Tinevez, J.-Y.
10.1101/2021.01.15.426809 — bioinformatics — Posted on 2021-01-17
2143 Variational autoencoders learn universal latent representations of metabolomics data
Gomari, D. P.; Schweickart, A.; Cerchietti, L.; Paietta, E.; Fernandez, H.; Al-Amin, H.; Suhre, K.; Krumsiek, J.
10.1101/2021.01.14.426721 — bioinformatics — Posted on 2021-01-17
2145 Metabolism Control in 3D Printed Living Materials
Butelmann, T.; Priks, H.; Parent, Z.; Johnston, T. G.; Tamm, T.; Nelson, A.; Lahtvee, P.-J.; Kumar, R.
10.1101/2021.01.15.426505 — bioengineering — Posted on 2021-01-17
2146 RIPK3 promoter hypermethylation in hepatocytes protects from bile acid induced inflammation and necroptosis
Hoff, J.; Xiong, L.; Kammann, T.; Neugebauer, S.; Micheel, J. M.; Ghait, M.; Deshmukh, S. D.; Press, A.; Bauer, M.; Gassler, N.
10.1101/2021.01.15.426790 — biochemistry — Posted on 2021-01-17
2150 Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease
Sanchez-Ceinos, J.; Guzman-Ruiz, R.; Rangel-Zuniga, O. A.; Moreno-Cano, E.; del Rio-Moreno, M.; Maymo-Masip, E.; Vendrell, J.; Fernandez-Veledo, S.; Laurencikiene, J.; Ryden, M.; Membrives, A.; Luque, R. M.; Lopez-Miranda, J.; M. Malagon, M.
10.1101/2021.01.15.426823 — cell biology — Posted on 2021-01-17
2151 Discovery of 10,828 new putative human immunoglobulin heavy chain IGHV variants
Martins, F. R.; Pontes, L. A. d. M.; Mendes, T. A. d. O.; Felicori, L. F.
10.1101/2021.01.15.426262 — immunology — Posted on 2021-01-17
2152 Metastatic Single Tumor Cells Evade NK Cell-mediated Killing by Thrombin-mediated Loss of the Activating Ligand CD155/PVR/Necl-5
Ichise, H.; Tsukamoto, S.; Hirashima, T.; Konishi, Y.; Oki, C.; Tsukiji, S.; Iwano, S.; Miyawaki, A.; Sumiyama, K.; Terai, K.; Matsuda, M.
10.1101/2021.01.15.426784 — immunology — Posted on 2021-01-17
2155 3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe
Yushkevich, P. A.; Munoz Lopez, M.; Iniguez de Onzono Martin, M. M.; Ittyerah, R.; Lim, S.; Ravikumar, S.; Bedard, M. L.; Pickup, S.; Liu, W.; Wang, J.; Hung, L. Y.; Lasserve, J.; Vergnet, N.; Xie, L.; Dong, M.; Cui, S.; McCollum, L.; Robinson, J. L.; Schuck, T.; de Flores, R.; Grossman, M.; Tisdall, M. D.; Prabhakaran, K.; Mizsei, G.; Das, S. R.; Artacho-Perula, E.; Arroyo Jimenez, M. d. M.; Marcos Rabal, M. P.; Molina Romero, F. J.; Cebada Sanchez, S.; Delgado Gonzalez, J. C.; de la Rosa-Prieto, C.; Corcoles Parada, M.; Lee, E. B.; Trojanowski, J. Q.; Ohm, D. T.; Wisse, L. E. M.; Wolk, D. A.
10.1101/2021.01.15.421909 — neuroscience — Posted on 2021-01-17
2157 Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory
Ramaglia, V.; Dubey, M.; Malpede, A.; Petersen, N.; de Vries, S. I.; Lee, D.; Schenk, G. J.; Gold, S. M.; Geurts, J. J. G.; Huitinga, I.; Gommerman, J.; Kole, M. H. P.
10.1101/2021.01.15.426022 — neuroscience — Posted on 2021-01-17
2159 Large-scale cellular-resolution imaging of neural activity in freely behaving mice
Leman, D. P.; Chen, I. A.; Bolding, K. A.; Tai, J.; Wilmerding, L. K.; Gritton, H. J.; Cohen, Y.; Yen, W. W.; Perkins, L. N.; Liberti, W. A.; Kilic, K.; Han, X.; Cruz-Martin, A.; Gardner, T. J.; Otchy, T. M.; Davison, I. G.
10.1101/2021.01.15.426462 — neuroscience — Posted on 2021-01-17
2163 Reconstructing tumor trajectories during therapy through integration of multiple measurement modalities.
Griffiths, J. I.; Chen, J.; O'Dea, A.; Sharma, P.; Winblad, O.; Trivedi, M.; Kalinsky, K.; Wisinski, K.; O'Regan, R.; Makhoul, I.; Spring, L.; Bardia, A.; Yuan, Y.; Jahanzeb, M.; Adler, F.; Cohen, A.; Bild, A.; Khan, Q.
10.1101/2021.01.14.426737 — systems biology — Posted on 2021-01-17
2165 Applying cis-regulatory codes to predict conserved and variable heat and cold stress response in maize
Zhou, P.; Enders, T. A.; Myers, Z. A.; Magnusson, E.; Crisp, P. A.; Noshay, J.; Cano, F. A. G.; Liang, Z.; Grotewold, E.; Greenham, K.; Springer, N. M.
10.1101/2021.01.15.426829 — plant biology — Posted on 2021-01-17
2166 Genotypic variation in soil penetration by maize roots is negatively related to ethylene-induced thickening
Vanhees, D. J.; Schneider, H. M.; Loades, K. W.; Bengough, A. G.; Bennett, M. J.; Pandey, B. K.; Brown, K. J.; Mooney, S. J.; Lynch, J.
10.1101/2021.01.15.426842 — plant biology — Posted on 2021-01-17
2169 Refinement of α-synuclein ensembles against SAXS data: Comparison of force fields and methods
Ahmed, M. C.; Skaanning, L. K.; Jussupow, A.; Newcombe, E. A.; Kragelund, B. B.; Camilloni, C.; Langkilde, A. E.; Lindorff-Larsen, K.
10.1101/2021.01.15.426794 — biophysics — Posted on 2021-01-17
2173 Ultrasound-mediated blood-brain barrier disruption improves anti-pyroglutamate3 Aβ antibody efficacy and enhances phagocyte infiltration into brain in aged Alzheimer's disease-like mice
Shi, Q.; Sun, T.; Zhang, Y.; Power, C.; Hoesch, C.; Antonelli, S.; Schroeder, M. K.; Caldarone, B. J.; Taudte, N.; Schenk, M.; Schilling, S.; McDannold, N.; Lemere, C. A.
10.1101/2021.01.15.426806 — bioengineering — Posted on 2021-01-17
2175 Evolution of cytokine production capacity in ancient and modern European populations
Dominguez-Andres, J.; Kuijpers, Y.; Bakker, O. B.; Jaeger, M.; Xu, C.-J.; van der Meer, J. W.; Jakobsson, M.; Bertranpetit, J.; Joosten, L. A.; Li, Y.; Netea, M. G.
10.1101/2021.01.14.426690 — genomics — Posted on 2021-01-17
2177 Split-wrmScarlet and split-sfGFP: Tools for faster, easier fluorescent labeling of endogenous proteins in Caenorhabditis elegans
Goudeau, J.; Sharp, C. S.; Paw, J.; Savy, L.; Leonetti, M. D.; York, A. G.; Updike, D. L.; Kenyon, C.; Ingaramo, M.
10.1101/2020.07.02.185249 — genetics — Posted on 2021-01-17
2178 Genetic nurture effects on education: a systematic review and meta-analysis
Wang, B.; Baldwin, J. R.; Schoeler, T.; Cheesman, R.; Barkhuizen, W.; Dudbridge, F.; Bann, D.; Morris, T. T.; Pingault, J.-B.
10.1101/2021.01.15.426782 — genetics — Posted on 2021-01-17
2182 Parallel adaptation in autopolyploid Arabidopsis arenosa is dominated by repeated recruitment of shared alleles
Konecna, V.; Bray, S.; Vlcek, J.; Bohutinska, M.; Pozarova, D.; Roy Choudhury, R.; Flis, P.; Salt, D. E.; Parisod, C. E.; Yant, L.; Kolar, F.
10.1101/2021.01.15.426785 — evolutionary biology — Posted on 2021-01-17
2183 Identifying priority areas for research and conservation of the largetooth sawfish Pristis pristis in Colombia and Panama
Lopez Angarita, J.; Cubillos-M, J. C.; Villate-Moreno, M.; Del Cid, A.; Diaz, J. M.; Cooke, R. G.; Tilley, A.
10.1101/2021.01.14.426658 — ecology — Posted on 2021-01-17
2184 Alternative futures for global biological invasions
Roura-Pascual, N.; Leung, B.; Rabitsch, W.; Rutting, L.; Vervoort, J.; Bacher, S.; Dullinger, S.; Erb, K.-H.; Jeschke, J. J.; Katsanevakis, S.; Kuhn, I.; Lenzner, B.; Liebhold, A. M.; Obersteiner, M.; Pauchard, A.; Peterson, G.; Roy, H. E.; Seebens, H.; Winter, M.; Burgman, M.; Genovesi, P.; Hulme, P. E.; Keller, R. P.; Latombe, G.; McGeoch, M. A.; Ruiz, G. M.; Scalera, R.; Springborn, M. R.; von Holle, B.; Essl, F.
10.1101/2021.01.15.426694 — ecology — Posted on 2021-01-17
2185 Ancient sedimentary DNA shows rapid post-glacial colonisation of Iceland followed by relatively stable vegetation until Landnam
Alsos, I. G.; Lammers, Y.; Kjellman, S. E.; Merkel, M. K.; Bender, E.; Rouillard, A.; Erlendsson, E.; Guthmundsdottir, E. R.; Benediktsson, I. O.; Farnsworth, W. R.; Brynjolfsson, S.; Gisladottir, G.; Eddudottir, S. D.; Schomacker, A.
10.1101/2021.01.15.426816 — ecology — Posted on 2021-01-17
2186 SCFFbxw5 targets MCAK in G2/M to facilitate ciliogenesis in the following cell cycle
Schweiggert, J.; Habeck, G.; Hess, S.; Mikes, F.; Meese, K.; Hata, S.; Knobeloch, K.-P.; Melchior, F.
10.1101/2021.01.15.426831 — cell biology — Posted on 2021-01-17
2187 Auto-qPCR: A Python based web app for automated and reproducible analysis of qPCR data
Maussion, G.; Thomas, R. A.; Demirova, I.; Gu, G.; Cai, E.; Chen, C. X.- Q.; Abdian, N.; Strauss, T. J. P.; Kelai, S.; Nauleau Javaudin, A.; Beitel, L. K.; Ramoz, N.; Gorwood, P.; Durcan, T.
10.1101/2021.01.14.426748 — molecular biology — Posted on 2021-01-17
2188 Multi-omic rejuvenation of human cells by maturation phase transient reprogramming
Gill, D.; Parry, A.; Santos, F.; Hernando-Herraez, I.; Stubbs, T. M.; Milagre, I.; Reik, W.
10.1101/2021.01.15.426786 — molecular biology — Posted on 2021-01-17
2189 The Pentose Phosphate Pathway constitutes a major metabolic hub in pathogenic Francisella
Rytter, H.; Jamet, A.; Ziveri, J.; RAMOND, E.; Coureuil, M.; Lagouge-Roussey, P.; Euphrasie, D.; Tros, F.; Goudin, N.; Chhuon, C.; Nemazanyy, I.; de Moraes, F. E.; Abate, C.; Guerrera, I. C.; charbit, a.
10.1101/2021.01.15.426780 — microbiology — Posted on 2021-01-17
2191 Mobile brain/body imaging of landmark-based navigation with high-density EEG
Delaux, A.; de Saint Aubert, J.-B.; Ramanoël, S.; Becu, M.; Gerhke, L.; Klug, M.; Chavarriaga, R.; Sahel, J.-A.; Gramann, K.; Arleo, A.
10.1101/2021.01.13.426330 — neuroscience — Posted on 2021-01-17
2192 Parallel functional testing identifies enhancers active in early postnatal mouse brain
Lambert, J. T.; Su-Feher, L.; Cichewicz, K.; Warren, T. L.; Zdilar, I.; Wang, Y.; Lim, K. J.; Haigh, J.; Morse, S. J.; Canales, C. P.; Stradleigh, T. W.; Castillo, E.; Haghani, V.; Moss, S. D.; Parolini, H.; Quintero, D.; Shrestha, D.; Vogt, D.; Byrne, L.; Nord, A. S.
10.1101/2021.01.15.426772 — neuroscience — Posted on 2021-01-17
2193 The Supplementary Eye Field Tracks Cognitive Efforts
Claron, J.; Royo, J.; Arcizet, F.; Deffieux, T.; Tanter, M.; Pouget, P.
10.1101/2021.01.14.426722 — neuroscience — Posted on 2021-01-17
2195 A conserved role of Parkinson-associated DJ-1 metabolites in sperm motility, mitosis, and embryonic development
Bour, S.; Dening, Y.; Balbach, M.; Poser, I.; Ramirez-Alvarez, I.; den Haan, H.; Kluge, C.; Naumann, R.; Oertel, R.; Alba-Alejandre, I.; Accardi, D.; Stief, C. G.; Dieterich, M.; Falkai, P.; Boeckmann, R. A.; Perez-Sanchez, H.; Hyman, A. A.; Trottmann, M.; Pan-Montojo, F. J.
10.1101/2021.01.16.426934 — developmental biology — Posted on 2021-01-17
2197 Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect
Yang, J.; Yu, Y.; Li, Y.; Yan, W.; Ye, H.; Niu, L.; Tang, M.; Wang, Z.; Yang, Z.; Pei, H.; Wei, H.; Zhao, M.; Wen, J.; Yang, L.; Ouyang, L.; Wei, Y.; Chen, Q.; Li, W.; Chen, L.
10.1101/2020.09.11.293563 — cell biology — Posted on 2021-01-17
2199 Activation of the type 3 secretion system of enteropathogenic E. coli leads to reprogrammingof its lipid metabolism
Zacharia, A.; Pal, R. R.; Katsowich, N.; Mannully, C. T.; ibrahem, a.; Alfandary, S.; Serruya, R.; Baidya, A.; Ben-Yehuda, S.; Rosenshine, I.; Moussaieff, A.
10.1101/2020.12.17.423234 — microbiology — Posted on 2021-01-17
2200 Selective vulnerability of supragranular layer neurons in schizophrenia
Batiuk, M. Y.; Tyler, T.; Mei, S.; Rydbirk, R.; Petukhov, V.; Sedmak, D.; Frank, E.; Feher, V.; Habek, N.; Hu, Q.; Igolkina, A.; Roszik, L.; Pfisterer, U.; Petanjek, Z.; Adorjan, I.; Kharchenko, P. V.; Khodosevich, K.
10.1101/2020.11.17.386458 — neuroscience — Posted on 2021-01-17
2201 A sexual dimorphic role of the miR-465 cluster in placental development
Wang, Z.; Meng, N.; Wang, Y.; Zhou, T.; Li, M.; Wang, S.; Chen, S.; Zheng, H.; Kong, S.; Wang, H.; Yan, W.
10.1101/2021.01.16.426973 — developmental biology — Posted on 2021-01-17
2202 Formation and Spontaneous Long-Term Repatterning of Headless Planarian Flatworms
Bischof, J.; LaPalme, J.; Miller, K.; Morokuma, J.; Williams, K.; Fields, C.; Levin, M.
10.1101/2021.01.15.426822 — developmental biology — Posted on 2021-01-17
2203 Functional differences drive the selection of NRAS mutants in melanoma
Murphy, B. M.; Weiss, T. J.; Holderbaum, A. M.; Dhakal, A.; Fort, M.; Bodnar, M. S.; Chen, M.; Burd, C. J.; COPPOLA, V.; Burd, C. E.
10.1101/2021.01.15.426808 — cancer biology — Posted on 2021-01-17
2206 Oncogenetic Network Estimation with Disjunctive Bayesian Networks
Nicol, P. B.; Coombes, K. R.; Deaver, C.; Chkrebtii, O. A.; Paul, S.; Toland, A. E.; Asiaee, A.
10.1101/2020.04.13.040022 — bioinformatics — Posted on 2021-01-17
2209 KIT is required for fetal liver erythropoiesis but dispensable for angiogenesis
Fantin, A.; Plein, A.; Tacconi, C.; Villa, E.; Ceccacci, E.; Denti, L.; Ruhrberg, C.
10.1101/2021.01.15.426801 — developmental biology — Posted on 2021-01-17
2211 An early-morning flowering trait in rice helps retain grain yield under heat stress field conditions at flowering stage
Ishimaru, T.; Hlaing, K. T.; Oo, Y. M.; Lwin, T. M.; Sasaki, K.; Lumanglas, P. D.; Simon, E.-V. M.; Myint, T. T.; Hairmansis, A.; Susanto, U.; Ayyenar, B.; Muthurajan, R.; Hirabayashi, H.; Fukuta, Y.; Kobayasi, K.; Matsui, T.; Yoshimoto, M.; Htun, T. M.
10.1101/2021.01.16.426929 — developmental biology — Posted on 2021-01-17
2212 A conserved role of Parkinson-associated DJ-1 metabolites in sperm motility, mitosis, and embryonic development
Bour, S.; Dening, Y.; Balbach, M.; Poser, I.; Ramirez-Alvarez, I.; den Haan, H.; Kluge, C.; Naumann, R.; Oertel, R.; Alba-Alejandre, I.; Accardi, D.; Stief, C. G.; Dieterich, M.; Falkai, P.; Boeckmann, R. A.; Perez-Sanchez, H.; Hyman, A. A.; Trottmann, M.; Pan-Montojo, F. J.
10.1101/2021.01.16.426934 — developmental biology — Posted on 2021-01-17
2215 Meiosis-specific ZFP541 repressor complex promotes meiotic prophase exit during spermatogenesis
Horisawa-Takada, Y.; Kodera, C.; Takemoto, K.; Sakashita, A.; Horisawa, K.; Maeda, R.; Usuki, S.; Fujimura, S.; Tani, N.; Matsuura, K.; Shimada, R.; Akiyama, T.; Suzuki, A.; Niwa, H.; Tachibana, M.; Ohba, T.; Katabuchi, H.; Namekawa, S. H.; Araki, K.; Ishiguro, K.-i.
10.1101/2021.01.15.426901 — developmental biology — Posted on 2021-01-17
2217 Protein Phosphatase 1 regulates atypical chromosome segregation and cell polarity during mitotic and meiotic division in Plasmodium sexual stages
Zeeshan, M.; Pandey, R.; SUBUDHI, A. K.; Ferguson, D. J. P.; Kaur, G.; Rashpa, R.; Nugmanova, R.; Brady, D.; Bottrill, A.; vaughan, s.; Brochet, M.; Bollen, M.; Pain, A.; Holder, A. A.; Guttery, D. S.; Tewari, R.
10.1101/2021.01.15.426883 — cell biology — Posted on 2021-01-17
2219 Salt Inducible Kinase activation and IRE1-dependent intracellular ATP depletion to form Sec bodies in Drosophila cells.
Rabouille, C.; Zhang, C.; van Leeuwen, W.; Blotenburg, M.; Aguilera-Gomez, A.; Brussee, S.; Kampinga, H. H.
10.1101/2021.01.16.426665 — cell biology — Posted on 2021-01-17
2222 Cognitive boundary signals in the human medial temporal lobe shape episodic memory representation
Zheng, J.; Gomez Palacio Schjetnan, A.; Yebra, M.; Mosher, C. P.; Kalia, S.; Valiante, T. A.; Mamelak, A.; Kreiman, G.; Rutishauser, U.
10.1101/2021.01.16.426538 — neuroscience — Posted on 2021-01-16
2223 Simplicial and Topological Descriptions of Human Brain Dynamics
Billings, J.; Saggar, M.; Hlinka, J.; Keilholz, S.; Petri, G.
10.1101/2020.09.06.285130 — neuroscience — Posted on 2021-01-17
2224 Evaluating features of scientific conferences: A call for improvements
Sarabipour, S.; Schwessinger, B.; Mumoki, F. N.; Mwakilili, A. D.; Khan, A.; Debat, H. J.; Saez, P.; Seah, S.; Mestrovic, T.
10.1101/2020.04.02.022079 — scientific communication and education — Posted on 2021-01-17
2225 The Cardiolipin Transacylase Tafazzin Regulates Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets from Mice
Cole, L. K.; Agarwal, P.; Doucette, C.; Fonseca, M.; Xiang, B.; Sparagna, G. C.; Seshadri, N.; Vandel, M.; Dolinsky, V.; Hatch, G.
10.1101/2021.01.15.426880 — physiology — Posted on 2021-01-17
2227 Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model.
Serra, I.; Manusama, O. R.; Kaiser, F. M. P.; Floriano, I. I.; Wahl, L.; Zalm, C. v. d.; IJspeert, H.; Hagen, P. M. v.; van Beveren, N. J. M.; Arend, S. M.; Okkenhaug, K.; Pel, J. J. M.; Dalm, V. A. S. H.; Badura, A.
10.1101/2021.01.15.426862 — neuroscience — Posted on 2021-01-16
2229 Tonic activity in lateral habenula neurons promotes disengagement from reward-seeking behavior
Sleezer, B. J.; Post, R. J.; Bulkin, D. A.; Ebitz, R. B.; Lee, V.; Han, K.; Warden, M. R.
10.1101/2021.01.15.426914 — neuroscience — Posted on 2021-01-16
2231 Learning from unexpected events in the neocortical microcircuit
Gillon, C. J.; Pina, J. E.; Lecoq, J.; Ahmed, R.; Billeh, Y.; Caldejon, S.; Groblewski, P.; Henley, T. M.; Kato, I.; Lee, E.; Luviano, J.; Mace, K.; Nayan, C.; Nguyen, T.; North, K.; Perkins, J.; Seid, S.; Valley, M.; Williford, A.; Bengio, Y.; Lillicrap, T. P.; Richards, B. A.; Zylberberg, J.
10.1101/2021.01.15.426915 — neuroscience — Posted on 2021-01-16
2236 A novel Wnt/beta-catenin signaling driven adipocyte population that is required for beiging
Liu, Z.; Chen, T.; Zhang, S.; Yang, T.; Gong, Y.; deng, H.-W.; Bai, D.; Tian, W.; Chen, Y.
10.1101/2021.01.14.426702 — physiology — Posted on 2021-01-16
2239 Ecological correlates of reproductive status in a guild of Afrotropical understory trees
Drager, A. P.; Weylandt, M.; Chuyong, G. B.; Kenfack, D.; Thomas, D. W.; Dunham, A. E.
10.1101/2021.01.14.426416 — ecology — Posted on 2021-01-16
2240 Atopic Biomarker Changes after Exposure to Porphyromonas gingivalis Lipopolysaccharide: A Small Experimental Study in Wistar Rat
Nelwan, S. C.; Nugraha, R. A.; Endaryanto, A.; Meizarini, A.; Tedjosasongko, U.; Pradopo, S.; Utomo, H.
10.1101/2021.01.14.426656 — immunology — Posted on 2021-01-16
2242 Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias
Vavouraki, N.; Tomkins, J. E.; Kara, E.; Houlden, H.; Hardy, J.; Tindall, M. J.; Lewis, P. A.; Manzoni, C.
10.1101/2021.01.14.425874 — systems biology — Posted on 2021-01-16
2244 Environment-Dependent Switch between Two Immune Systems against Ralstonia solanacearum Infections in Pepper
Yang, S.; Cai, W.; Shen, L.; Wu, R.; Cao, J.; Cai, J.; He, S.; Zheng, Y.; Zhang, Q.; Wang, A.; Guan, D.; He, S.
10.1101/2021.01.14.426660 — plant biology — Posted on 2021-01-16
2245 A triple-negative matrix-producing breast carcinoma is arrested by tumor-targeting Salmonella typhimurium A1-R in a PDOX model
Hamada, K.; Yamamoto, J.; Hozumi, C.; Zhao, M.; Murata, T.; Sugisawa, N.; Sun, Y.; Aoki, Y.; Nishino, H.; Bouvet, M.; Tsunoda, T.; Hoffman, R. M.
10.1101/2021.01.14.426747 — cancer biology — Posted on 2021-01-16
2247 MolRep: A Deep Representation Learning Library for Molecular Property Prediction
Rao, J.; Zheng, S.; Song, Y.; Chen, J.; Li, C.; Xie, J.; Yang, H.; Chen, H.; Yang, Y.
10.1101/2021.01.13.426489 — bioinformatics — Posted on 2021-01-16
2252 Myoglobin primary structure reveals multiple convergent transitions to semi-aquatic life in the world smallest mammalian divers
He, K.; Eastman, T. G.; Czolacz, H.; Li, S.; Shinohara, A.; Kawada, S.-i.; Springer, M.; Berenbrink, M.; Campbell, K. L.
10.1101/2021.01.14.426706 — evolutionary biology — Posted on 2021-01-16
2254 Data proliferation, reconciliation, and synthesis in viral ecology
Gibb, R.; Albery, G. F.; Becker, D. J.; Brierley, L.; Connor, R.; Dallas, T. A.; Eskew, E. A.; Farrell, M. J.; Rasmussen, A. L.; Ryan, S. J.; Sweeny, A. R.; Carlson, C. J.; Poisot, T.
10.1101/2021.01.14.426572 — ecology — Posted on 2021-01-16
2255 Microclimates can be accurately predicted across ecologically important remote ecosystems
Baker, D. J.; Dickson, C. R.; Bergstrom, D. M.; Whinam, J.; Maclean, I. M.; McGeoch, M. A.
10.1101/2021.01.14.426699 — ecology — Posted on 2021-01-16
2257 The total mRNA concentration buffering system in yeast is global rather than gene-specific
Garcia-Martinez, J.; Medina, D. A.; Bellvis, P.; Sun, M.; Cramer, P.; Chavez, S.; Perez-Ortin, J. E.
10.1101/2021.01.14.426689 — molecular biology — Posted on 2021-01-16
2258 Mitochondrial function is essential for humoral immunity by controlling flux of the TCA cycle, phosphatidic acid and mTOR activity in B cells
Urbanczyk, S.; Baris, O.; Hofmann, J.; Golombek, F.; Castiglione, K.; Meng, X.; Bozec, A.; Mougiakakos, D.; Schulz, S. R.; Schuh, W.; Schloetzer-Schrehardt, U.; Steinmetz, T.; Brodesser, S.; Wiesner, R. J.; Mielenz, D.
10.1101/2021.01.14.426649 — immunology — Posted on 2021-01-16
2259 Opioid withdrawal produces sex-specific effects on fentanyl-vs.-food choice and mesolimbic transcription
Townsend, E. A.; Kim, R. K.; Robinson, H. L.; Marsh, S. A.; Banks, M. L.; Hamilton, P. J.
10.1101/2021.01.14.426662 — neuroscience — Posted on 2021-01-16
2264 Identifying Plasmodium falciparum transmission patterns through parasite prevalence and entomological inoculation rate
Amoah, B.; McCann, R. S.; Kabaghe, A. N.; Mburu, M.; Chipeta, M. G.; Moraga, P.; Gowelo, S.; Tizifa, T.; van den Berg, H.; Mzilahowa, T.; Takken, W.; van Vugt, M.; Phiri, K. S.; Diggle, P. J.; Terlouw, D. J.; Giorgi, E.
10.1101/2021.01.14.426709 — physiology — Posted on 2021-01-16
2265 A Novel in vitro Model for Mature Toxoplasma gondii Bradyzoites Reveals their Metabolome and a Diminished Role of the Mitochondrial Tricarboxylic Acid Cycle
Christiansen, C.; Maus, D.; Melerowicz, F.; Scholz, J.; Murillo-Leon, M.; Steinfeldt, T.; Hoffmann, T.; Seeber, F.; Blume, M.
10.1101/2021.01.15.426845 — microbiology — Posted on 2021-01-16
2266 De novo assembly, annotation, and comparative analysis of 26 diverse maize genomes
Hufford, M. B.; Seetharam, A. S.; Woodhouse, M. R.; Chougule, K. M.; Ou, S.; LIU, J.; Ricci, W. A.; Guo, T.; Olson, A.; Qiu, Y.; Della Coletta, R.; Tittes, S.; Hudson, A. I.; Marand, A. P.; Wei, S.; Lu, Z.; Wang, B.; Tello-Ruiz, M. K.; Piri, R. D.; Wang, N.; Kim, D. w.; Zeng, Y.; O'Connor, C. H.; Li, X.; Gilbert, A. M.; Baggs, E.; Krasileva, K. V.; Portwood, J. L.; Cannon, E. K.; Andorf, C. M.; MANCHANDA, N.; Snodgrass, S. J.; Hufnagel, D. E.; Jiang, Q.; Pedersen, S.; Syring, M. L.; Kudrna, D. A.; Llaca, V.; Fengler, K.; Schmitz, R. J.; Ross-Ibarra, J.; Yu, J.; Gent, J. I.; Hirsch, C. N.; Ware
10.1101/2021.01.14.426684 — genomics — Posted on 2021-01-16
2267 Genetic Control of Pluripotency Epigenome Determines Differentiation Bias in Mouse Embryonic Stem Cells
Byers, C.; Spruce, C.; Fortin, H. J.; Czechanski, A.; Munger, S. C.; Reinholdt, L. G.; Skelly, D. A.; Baker, C. L.
10.1101/2021.01.15.426861 — genomics — Posted on 2021-01-16
2268 Mechanisms Driving Genome Reduction of a Novel Roseobacter Lineage Showing Vitamin B12 Auxotrophy
Feng, X.; Chu, X.; Qian, Y.; Henson, M. W.; Lanclos, V. C.; Qin, F.; Zhao, Y.; Thrash, C.; Luo, H.
10.1101/2021.01.15.426902 — microbiology — Posted on 2021-01-16
2269 Compound FC-10696 Inhibits Egress and Spread of Marburg Virus
Han, Z.; Ye, H.; Liang, J.; Shepley-McTaggart, A.; Wrobel, J. E.; Reitz, A. B.; Whigham, A.; Kavelish, K. N.; Saporito, M. S.; Freedman, B.; Shtanko, O.; Harty, R. N.
10.1101/2021.01.15.426918 — microbiology — Posted on 2021-01-16
2271 Conditional deletion of HIF-1α provides new insight regarding the murine response to gastrointestinal infection with Salmonella Typhimurium
Robrahn, L.; Dupont, A.; Jumpertz, S.; Zhang, K.; Holland, C.; Guillaume, J.; Rappold, S.; Cerovic, V.; Saez, J.; Hornef, M.; Cramer, T.
10.1101/2021.01.16.426940 — microbiology — Posted on 2021-01-16
2272 First evidence of nocardiosis in farmed red drum (Sciaenops ocellatus, Linnaeus) caused by Nocardia seriolae in the Gulf of Mexico
del Rio-Rodriguez, R. E.; Ramirez-Paredes, G.; Soto-Rodriguez, S. A.; Shapira, Y.; Huchin-Cortes, M. d. J.; Ruiz-Hernandez, J.; Gomez-Solano, M. I.; Haydon, D.
10.1101/2021.01.15.426713 — microbiology — Posted on 2021-01-16
2273 The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold
Moison, M.; Martinez Pacheco, J.; Lucero, L.; Fonouni-Farde, C.; Rodriguez-Melo, J.; Mansilla, N.; Christ, A.; Bazin, J.; Benhamed, M.; Ibanez, F.; Crespi, M.; Estevez, J.; Ariel, F.
10.1101/2020.07.13.188763 — plant biology — Posted on 2021-01-16
2275 A Stomata Classification and Detection System in Microscope Images of Maize Cultivars
Aono, A. H.; Nagai, J. S.; Dickel, G.; Marinho, R. C.; Oliveira, P.; Papa, J. P.; Faria, F.
10.1101/538165 — plant biology — Posted on 2021-01-16
2276 Inter- and intra-specific variation in hair cortisol concentrations of Neotropical bats
Sandoval Herrera, N. I.; Mastromonaco, G.; Becker, D.; Simmons, N. B.; Welch, K. C.
10.1101/2021.01.10.426004 — ecology — Posted on 2021-01-16
2279 Targeting EGFR in glioblastoma with a novel brain-penetrant small molecule EGFR-TKI
Ni, J.; Wang, Y.; Wang, Q.; Bergholz, J. S.; Jiang, T.; Roberts, T. M.; Gray, N. S.; Zhao, J. J.
10.1101/2021.01.09.426030 — cancer biology — Posted on 2021-01-16
2280 On a Reef Far, Far Away: Anthropogenic Impacts Following Extreme Storms Affect Sponge Health and Bacterial Communities
Shore, A.; Sims, J. A.; Grimes, M.; Howe-Kerr, L. I.; Grupstra, C. G. B.; Doyle, S. M.; Stadler, L.; Sylvan, J. B.; Shamberger, K. E.; Davies, S. W.; Santiago-Vasquez, L. Z.; Correa, A. M.
10.1101/2020.04.27.064568 — microbiology — Posted on 2021-01-16
2284 Spatial structure impacts adaptive therapy by shaping intra-tumoral competition
Strobl, M. A. R.; Gallaher, J.; West, J.; Robertson-Tessi, M.; Maini, P. K.; Anderson, A.
10.1101/2020.11.03.365163 — cancer biology — Posted on 2021-01-16
2285 Measuring expression heterogeneity of single-cell cytoskeletal protein complexes
Vlassakis, J.; Hansen, L. L.; Higuchi-Sanabria, R.; Zhou, Y.; Tsui, C. K.; Dillin, A.; Huang, H.; Herr, A. E.
10.1101/2020.09.12.294801 — bioengineering — Posted on 2021-01-16
2289 Sleep problems in preschoolers with autism spectrum disorders are associated with sensory sensitivities and thalamocortical overconnectivity
Linke, A. C.; Chen, B.; Olson, L.; Ibarra, C.; Fong, C. H.; Reynolds, S.; Apostol, M.; Kinnear, M. K.; Muller, R.-A.; Fishman, I.
10.1101/2021.01.15.426899 — neuroscience — Posted on 2021-01-15
2290 Serotonin modulates learning content-specific neuroplasticity of functional brain networks
Klöbl, M.; Seiger, R.; Vanicek, T.; Handschuh, P.; Reed, M. B.; Spurny, B.; Ritter, V.; Godbersen, G. M.; Gryglewski, G.; Kraus, C.; Hahn, A.; Lanzenberger, R.
10.1101/2021.01.15.426779 — neuroscience — Posted on 2021-01-15
2292 From plants to ants: Fungal modification of leaf lipids for nutrition and communication in the leaf-cutter ant fungal garden ecosystem
Khadempour, L.; Kyle, J. E.; Webb-Robertson, B.-J. M.; Nicora, C. D.; Smith, F. B.; Smith, R. D.; Lipton, M. S.; Currie, C. R.; Baker, E. S.; Burnum-Johnson, K. E.
10.1101/2020.07.28.224139 — systems biology — Posted on 2021-01-15
2294 Anterior insula-associated social novelty recognition: orchestrated regulation by a local retinoic acid cascade and oxytocin signaling
Kim, S.-H.; An, K.; Namkung, H.; Rannals, M. D.; Moore, J. R.; Cash-Padgett, T.; Mihaljevic, M.; Saha, S.; Oh, L. S.; Kondo, M. A.; Yang, K.; Maher, B. J.; Niwa, M.; Sawa, A.
10.1101/2021.01.15.426848 — animal behavior and cognition — Posted on 2021-01-15
2295 Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Shwachman-Diamond syndrome
Lee, S.; Shin, C. H.; Lee, J.; Jeong, S. D.; Hong, C. R.; Kim, J.-D.; Kim, A.-R.; Son, S. J.; Kokhan, O.; Yoo, T.; Ko, J. S.; Sohn, Y. B.; Kim, O.-H.; Ko, J. M.; Cho, T.-J.; Wright, N. T.; Seong, J. K.; Jin, S.-W.; Kang, H. J.; Kim, H. H.; Choi, M.
10.1101/483362 — genetics — Posted on 2021-01-15
2296 New insights into large tropical tree mass and structure from direct harvest and terrestrial lidar
Burt, A.; Boni Vicari, M.; da Costa, A. C. L.; Coughlin, I.; Meir, P.; Rowland, L.; Disney, M.
10.1101/2020.09.29.317198 — ecology — Posted on 2021-01-15
2300 Beyond linearity in neuroimaging: Capturing nonlinear relationships with application to longitudinal studies
Chen, G.; Nash, T. A.; Reding, K. M.; Kohn, P. D.; Wei, S.-M.; Gregory, M. D.; Eisenberg, D. P.; Cox, R. W.; Berman, K. F.; Kippenhan, J. S.
10.1101/2020.11.01.363838 — neuroscience — Posted on 2021-01-15
2304 Measuring expression heterogeneity of single-cell cytoskeletal protein complexes
Vlassakis, J.; Hansen, L. L.; Higuchi-Sanabria, R.; Zhou, Y.; Tsui, C. K.; Dillin, A.; Huang, H.; Herr, A. E.
10.1101/2020.09.12.294801 — bioengineering — Posted on 2021-01-15
2305 Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis
Reddy, H. M.; Bhattacharya, R.; Jehan, Z.; Mishra, K.; Annapurna, P.; Tiwari, S.; Praveena, N. M.; Alex, J. L.; Dhople, V. M.; Singh, L.; Sivaramakrishnan, M.; Chaturvedi, A.; Rangaraj, N.; Shiju, T. M.; Sridevi, B.; Kumar, S.; Dereddi, R. R.; Rayabandla, S.; Jesudasan, R. A.
10.1101/285429 — genomics — Posted on 2021-01-15
2306 Insights into the genomic evolution of insects from cricket genomes
Ylla, G.; Nakamura, T.; Itoh, T.; Kajitani, R.; Toyoda, A.; Tomonari, S.; Bando, T.; Ishimaru, Y.; Watanabe, T.; Fuketa, M.; Matsuoka, Y.; Barnett, A.; Noji, S.; Mito, T.; Extavour, C. G.
10.1101/2020.07.07.191841 — genomics — Posted on 2021-01-15
2308 The potential of parrotfish faeces in replenishing reefs with coral-associated microbiome
Velasquez-Rodriguez, T. M.; Zuluaga-Arias, C.; Montano, S. M.; Gonzalez, J. M.; Sanchez, J. A.
10.1101/2020.09.15.298737 — ecology — Posted on 2021-01-15
2309 A signaling axis involving CNOT3, Aurora B and ERK promotes mesendodermal differentiation of ES cells in response to FGF2 and BMP4
Sarkar, M.; Martufi, M.; Roman-Trufero, M.; Wang, Y.-F.; Whilding, C.; Dormann, D.; Sabbattini, P.; Dillon, N.
10.1101/756932 — developmental biology — Posted on 2021-01-15
2310 Spatiotemporal transcriptional dynamics of the cycling mouse oviduct
Roberson, E.; Battenhouse, A.; Garge, R.; Tran, N. K.; Marcotte, E.; Wallingford, J.
10.1101/2021.01.15.426867 — developmental biology — Posted on 2021-01-15
2311 Evolution of lbx spinal cord expression and function
Juarez-Morales, J. L.; Weierud, F.; England, S.; Demby, C.; Santos, N.; Mazan, S.; Lewis, K.
10.1101/2020.12.30.424885 — developmental biology — Posted on 2021-01-15
2312 BAZ2A association with H3K14ac is required for the transition of prostate cancer cells into a cancer stem-like state
Pena-Hernandez, R.; Aprigliano, R.; Frommel, S.; Pietrzak, K.; Steiger, S.; Roganowicz, M.; Bizzarro, J.; Santoro, R.
10.1101/2020.07.03.185843 — molecular biology — Posted on 2021-01-15
2313 Accurate bulk quantitation of droplet digital PCR
Sun, C.; Liu, L.; Vasudevan, H.; Chang, K.-C.; Abate, A.
10.1101/2021.01.13.424628 — molecular biology — Posted on 2021-01-15
2315 CAR-NK Cells Effectively Target the D614 and G614 SARS-CoV-2-infected Cells
Ma, M.; Badeti, S.; Chen, C.-H.; Pinter, A.; Jiang, Q.; Shi, L.; Zhou, R.; Xu, H.; Li, Q.; Gause, W.; Liu, D.
10.1101/2021.01.14.426742 — immunology — Posted on 2021-01-15
2317 Consistent cross-modal identification of cortical neurons with coupled autoencoders
Gala, R.; Budzillo, A.; Baftizadeh, F.; Miller, J. A.; Gouwens, N. W.; Arkhipov, A.; Murphy, G.; Tasic, B.; Zeng, H.; Hawrylycz, M.; Sümbül, U.
10.1101/2020.06.30.181065 — neuroscience — Posted on 2021-01-15
2318 Microglia perform local protein synthesis at perisynaptic and phagocytic structures
Vasek, M. J.; Deajon-Jackson, J. D.; Liu, Y.; Crosby, H. W.; Yi, J.; Dougherty, J. D.
10.1101/2021.01.13.426577 — neuroscience — Posted on 2021-01-15
2321 CKS1-dependent proteostatic regulation has dual roles combating acute myeloid leukemia whilst protecting normal hematopoiesis
Grey, W.; Rio-Machin, A.; Casado-Izquierdo, P.; Miettinen, J.; Copley, F.; Parsons, A.; Heckman, C.; Cutillas, P.; Gribben, J.; Fitzgibbon, J.; Bonnet, D.
10.1101/2020.12.27.423419 — cancer biology — Posted on 2021-01-15
2322 Cell cycle-dependent active stress drives epithelia remodeling
Devany, J.; Sussman, D. M.; Yamamoto, T.; Manning, M. L.; Gardel, M. L.
10.1101/804294 — biophysics — Posted on 2021-01-15
2324 Robust T1 MRI cortical surface pipeline for neonatal brain and systematic evaluation using multi-site MRI datasets
Liu, M.; Lepage, C.; Kim, S. Y.; Jeon, S.; Kim, S. H.; Simon, J. P.; Tanaka, N.; Yuan, S.; Islam, T.; Peng, B.; Yun, K.; Surento, W.; Kim, J.; Jahanshad, N.; Styner, M. A.; Toga, A. W.; Barkovich, A. J.; Xu, D.; Evans, A. C.; Kim, H.
10.1101/2021.01.13.426611 — bioinformatics — Posted on 2021-01-15
2325 RBCeq: An Integrated Bioinformatics Algorithm Designed to Improve Blood Type Compatibility Testing
Jadhao, S. S.; Davison, C.; Roulis, E. V.; Schoeman, E. M.; Divate, M. D.; Shankar, A. J.; Lee, S.; Pecheniuk, N. M.; Irving, D. O.; Hyland, C. A.; Flower, R. L.; Nagaraj, S. H.
10.1101/2021.01.13.426510 — bioinformatics — Posted on 2021-01-15
2328 Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes risk
Chiou, J.; Geusz, R.; Okino, M.-L.; Han, J. Y.; Miller, M.; Benaglio, P.; Huang, S.; Korgaonkar, K.; Heller, S.; Kleger, A.; Preissl, S.; Gorkin, D.; Sander, M.; Gaulton, K. J.
10.1101/2021.01.13.426472 — genetics — Posted on 2021-01-15
2330 Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development
Lima, A.; Lubatti, G.; Burgstaller, J.; Hu, D.; Green, A.; di Gregorio, A.; Zawadzki, T.; Pernaute, B.; Mahammadov, E.; Perez Montero, S.; Dore, M.; Sanchez, J. M.; Bowling, S.; Sancho, M.; Karimi, M.; Carling, D.; Jones, N.; Srinivas, S.; Scialdone, A.; Rodriguez, T. A.
10.1101/2020.01.15.900613 — developmental biology — Posted on 2021-01-15
2331 Motor Protein MYO1C is Critical for Photoreceptor Opsin Trafficking and Visual Function
Solanki, A.; Walterhouse, S.; Martin, R.; Obert, E.; Arif, E.; Rahman, B.; Rohrer, B.; Lipschutz, J. H.; Mukherjee, R. D.; Norris, R. A.; Sundstrom, J.; Knolker, H.-J.; Husain, S.; Biswal, M. R.; Nihalani, D.; Lobo, G. P.
10.1101/2020.06.02.129890 — cell biology — Posted on 2021-01-15
2335 Lower neural value signaling in the prefrontal cortex is related to childhood family income and depressive symptomatology during adolescence
Palacios-Barrios, E. E.; Hanson, J. L.; Barry, K. R.; Albert, D.; White, S. F.; Skinner, A. T.; Dodge, K. A.; Lansford, J. E.
10.1101/2021.01.13.426547 — neuroscience — Posted on 2021-01-15
2336 A large-scale neural network training framework for generalized estimation of single-trial population dynamics
Keshtkaran, M. R.; Sedler, A. R.; Chowdhury, R. H.; Tandon, R.; Basrai, D.; Nguyen, S. L.; Sohn, H.; Jazayeri, M.; Miller, L. E.; Pandarinath, C.
10.1101/2021.01.13.426570 — neuroscience — Posted on 2021-01-15
2339 Fatigue, Alertness and Risk Prediction for Shift Workers
Creator, S. F.; Coutts, L. V.; Phillips, R.; Turner, R.; Dijk, D.-J.; Skeldon, A. C.
10.1101/2021.01.13.426509 — neuroscience — Posted on 2021-01-15
2340 Controlling one's world: identification of sub-regions of primate PFC underlying goal-directed behavior
Duan, L. Y.; Horst, N. K.; Cranmore, S. A.; Horiguchi, N.; Cardinal, R. N.; Roberts, A. C.; Robbins, T. W.
10.1101/2021.01.13.426375 — neuroscience — Posted on 2021-01-15
2341 Anesthetics fragment hippocampal network activity, alter spine dynamics and affect memory consolidation
Yang, W.; Chini, M.; Poepplau, J. A.; Formozov, A.; Dieter, A.; Piechocinski, P.; Rais, C.; Morellini, F.; Sporns, O.; Hanganu-Opatz, I. L.; Wiegert, J. S.
10.1101/2020.06.05.135905 — neuroscience — Posted on 2021-01-15
2343 ATRIOVENTRICULAR NODAL FUNCTION, ATRIAL FIBRILLATION AND VENTRICULAR TACHYCARDIA IN GIRAFFES
Shivkumar, T. E.; Hadaya, J.; Bertelsen, M. F.; Aalkjaer, C.; Smerup, M. H.; Wang, T.; Ajijola, O. A.; Horowitz, B. N.
10.1101/2021.01.14.426686 — zoology — Posted on 2021-01-15
2344 A single-cell based precision medicine approach using glioblastoma patient-specific models
Park, J. H.; Feroze, A. H.; Emerson, S. N.; Mihalas, A. B.; Keene, C. D.; Cimino, P. J.; Lopez Garcia de Lomana, A.; Kannan, K.; Wu, W.-J.; Turkarslan, S.; Baliga, N.; Patel, A.
10.1101/2021.01.13.426485 — systems biology — Posted on 2021-01-15
2345 Comprehensive mapping of local and diaspora scientists: a database and analysis of 63951 Greek scientists
Ioannidis, J.; Koutsioumpa, C.; Vakka, A.; Agoranos, G.; Mantsiou, C.; Drekolia, M. K.; Avramidis, N.; Contopoulos-Ioannidis, D.; Drosatos, K.; Baas, J.
10.1101/2021.01.13.426588 — scientific communication and education — Posted on 2021-01-15
2347 Structural characterization of cocktail-like targeting polysaccharides from Ecklonia kurome Okam and their anti-SARS-CoV-2 activities in vitro
Ding, K.; Zhang, B.; Chen, X.; Xu, Y.; Huang, C.; Jin, C.; Du, Z.; Chen, X.; Ding, Y.; Sun, H.; Li, M.; Pei, R.; Zhang, S.; Su, M.; Zhang, Y.; Li, J.
10.1101/2021.01.14.426521 — biochemistry — Posted on 2021-01-15
2348 In vivo structure and dynamics of the RNA genome of SARS-Cov-2
Zhang, Y.; Huang, K.; Xie, D.; Lau, J. Y.; Shen, W.; Li, P.; Wang, D.; Zou, Z.; Shi, S.; Ren, H.; Jin, M.; Kudla, G.; Zhao, Z.
10.1101/2021.01.15.426526 — genomics — Posted on 2021-01-15
2349 Single-cell analysis of colonic epithelium reveals unexpected shifts in cellular composition and molecular phenotype in treatment-naiïve adult Crohn's disease
Kanke, M.; Kennedy, M. M.; Connelly, S.; Schaner, M.; Shanahan, M. T.; Wolber, E. A.; Beasley, C.; Lian, G.; Jain, A.; Long, M. D.; Barnes, E. L.; Herfarth, H. H.; Isaacs, K. L.; Hansen, J. J.; Kapadia, M.; Guillem, J. G.; Furey, T. S.; Sheikh, S. Z.; Sethupathy, P.
10.1101/2021.01.13.426602 — genomics — Posted on 2021-01-15
2351 Maternal infection promotes offspring tissue-specific immune fitness
Lim, A. I.; McFadden, T.; Link, V.; Han, S.-J.; Karlsson, R.-M.; Stacy, A.; Farley, T. K.; Harrison, O. J.; Shih, H.-Y.; Cameron, H. A.; Belkaid, Y.
10.1101/2021.01.13.426542 — immunology — Posted on 2021-01-15
2352 Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in Idiopathic Pulmonary Fibrosis
Marchal-Duval, E.; Homps-Legrand, M.; Froidure, A.; Jaillet, M.; Ghanem, M.; Deneuville, L.; Justet, A.; Maurac, A.; Vadel, A.; Fortas, E.; Cazes, A.; Joannes, A.; Giersch, L.; Mal, H.; Mordant, P.; Mounier, C. M.; Schirduan, X.; Korfei, M.; Gunther, A.; Mari, B.; Jaschinski, F.; Crestani, B.; Mailleux, A. A.
10.1101/2021.01.15.425870 — cell biology — Posted on 2021-01-15
2353 Mitotic R-loops direct Aurora b kinase to maintain centromeric cohesion
Moran, E.; Liu, L.; Zasadzinska, E.; Kestner, C.; Sarkeshik, A.; De Hoyos, H.; Yates, J. R.; Foltz, D.; Stukenberg, T.
10.1101/2021.01.14.426738 — cell biology — Posted on 2021-01-15
2354 Patrolling human SLE haematopoietic progenitors demonstrate enhanced extramedullary colonisation; implications for peripheral tissue injury
Kokkinopoulos, I.; Banos, A.; Grigoriou, M.; Filia, A.; Manolakou, T.; Alissafi, T.; Malissovas, N.; Mitroulis, I.; Verginis, P.; Boumpas, D. T.
10.1101/2021.01.15.426761 — cell biology — Posted on 2021-01-15
2357 Quantitative 3D microscopy reveals a genetic network predicting the local activity of anti-Aβ compounds
Kirschenbaum, D.; Voigt, F.; Dadgar-Kiani, E.; Catto, F.; Trevisan, C.; Bichsel, O.; Shirani, H.; Nilsson, P. K. R.; Frontzek, K.; Paganetti, P.; Helmchen, F.; Lee, J.-H.; Aguzzi, A.
10.1101/2021.01.15.426090 — neuroscience — Posted on 2021-01-15
2359 Spatiotemporal transcriptional dynamics of the cycling mouse oviduct
Roberson, E.; Battenhouse, A.; Garge, R.; Tran, N. K.; Marcotte, E.; Wallingford, J.
10.1101/2021.01.15.426867 — developmental biology — Posted on 2021-01-15
2361 Adiponectin Preserves Metabolic Fitness During Aging
Scherer, P. E.; Li, N.; Zhang, Z.; Zhao, S.; Zhu, Y.; Gliniak, C. M.; Vishvanath, L.; An, Y. A.; Wang, M.-y.; Deng, Y.; Zhu, Q.; Onodera, T.; Oz, O.; Gordillo, R.; Gupta, R. K.; Liu, M.; Horvath, T. L.; Dixit, V. D.
10.1101/2021.01.14.426678 — cell biology — Posted on 2021-01-15
2362 Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle
Lo, H.; Lim, Y.-W.; Xiong, Z.; Martel, N.; Ferguson, C.; Ariotti, N.; Giacomotto, J.; Rae, J.; Floetenmeyer, M.; Moradi, S. V.; Gao, Y.; Tillu, V.; Xia, D.; Wang, H.; Rahnama, S.; Nixon, S.; Bastiani, M.; Day, R.; Smith, K.; Palpant, N.; Johnston, W.; Alexandrov, K.; Collins, B.; Hall, T.; Parton, R.
10.1101/2021.01.13.426456 — cell biology — Posted on 2021-01-15
2365 Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hotspots, Functional Crosstalk and Regulatory Interactions in SARS-CoV-2
Gupta, V.; Haider, S.; Verma, M.; Singhvi, N.; Ponnusamy, K.; Malik, M. Z.; Verma, H.; Kumar, R.; Sood, U.; Hira, P.; Satija, S.; Lal, R.; Singh, Y.
10.1101/2020.06.20.162560 — microbiology — Posted on 2021-01-15
2366 Decoding locomotion from population neural activity in moving C. elegans
Hallinen, K. M.; Dempsey, R.; Scholz, M.; Yu, X.; Linder, A. N.; Randi, F.; Sharma, A. K.; Shaevitz, J. W.; Leifer, A.
10.1101/445643 — neuroscience — Posted on 2021-01-15
2367 Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression
Carossino, M.; Montanaro, P.; O'Connell, A.; Kenney, D.; Gertje, H.; Grosz, K.; Kurnick, S.; Bosmann, M.; Saeed, M.; Balasuriya, U.; Douam, F.; Crossland, N.
10.1101/2021.01.13.425144 — pathology — Posted on 2021-01-15
2368 Motor Protein MYO1C is Critical for Photoreceptor Opsin Trafficking and Vision
Solanki, A.; Walterhouse, S.; Martin, R.; Obert, E.; Arif, E.; Rahman, B.; Rohrer, B.; Lipschutz, J. H.; Mukherjee, R. D.; Norris, R. A.; Sundstrom, J.; Knolker, H.-J.; Husain, S.; Biswal, M. R.; Nihalani, D.; Lobo, G. P.
10.1101/2020.06.02.129890 — cell biology — Posted on 2021-01-15
2370 CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge
Lien, C.-E.; Lin, Y.-J.; Chen, C.; Lian, W.-C.; Kuo, T.-Y.; Campbell, J. D.; Traquina, P.; Lin, M.-Y.; Liu, L. T. C.; Chuang, Y.-S.; Ku, H.-Y.; Liao, C.-C.; Chen, Y.-H.; Jan, J.-T.; Sun, C.-P.; Lin, Y.-S.; Wu, P.-Y.; Wang, Y.-C.; Tao, M.-H.; Lin, Y.-L.
10.1101/2021.01.07.425674 — microbiology — Posted on 2021-01-15
2372 Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates
Zabaleta, N.; Dai, W.; Bhatt, U.; Chichester, J. A.; Sanmiguel, J.; Estelien, R.; Michalson, K. T.; Diop, C.; Maciorowski, D.; Qi, W.; Hudspeth, E.; Cucalon, A.; Dyer, C. D.; Pampena, M. B.; Knox, J. J.; LaRocque, R. C.; Charles, R. C.; Li, D.; Kim, M.; Sheridan, A.; Storm, N.; Johnson, R. I.; Feldman, J.; Hauser, B. M.; Ryan, A.; Zinn, E.; Kobayashi, D. T.; Chauhan, R.; McGlynn, M.; Ryan, E. T.; Schmidt, A. G.; Price, B.; Honko, A.; Griffiths, A.; Yaghmour, S.; Hodge, R.; Betts, M. R.; Freeman, M. W.; Wilson, J. M.; Vandenberghe, L. H.
10.1101/2021.01.05.422952 — immunology — Posted on 2021-01-15
2374 Parallel functional testing identifies enhancers active in early postnatal mouse brain
Lambert, J. T.; Su-Feher, L.; Cichewicz, K.; Warren, T. L.; Zdilar, I.; Wang, Y.; Lim, K. J.; Haigh, J.; Morse, S. J.; Stradleigh, T. W.; Castillo, E.; Haghani, V.; Moss, S. D.; Parolini, H.; Quintero, D.; Shrestha, D.; Vogt, D.; Byrne, L.; Nord, A. S.
10.1101/2021.01.15.426772 — neuroscience — Posted on 2021-01-15
2377 Identification of the Molecular Targets of Disulfide Bond Disrupting Agents
Law, M. E.; Yaaghubi, E.; Ghilardi, A.; Davis, B. J.; Ferreira, R. B.; Koh, J.; Chen, S.; DePeter, S. F.; Schilson, C. M.; Chiang, C.-W.; Heldermon, C. D.; Norgaard, P.; Castellano, R. K.; Law, B. K.
10.1101/2021.01.13.426390 — pharmacology and toxicology — Posted on 2021-01-15
2378 Distinct Patterns of Emergence of SARS-CoV-2 Spike Variants including N501Y in Clinical Samples in Columbus Ohio
Tu, H.; Avenarius, M. R.; Kubatko, L.; Hunt, M.; Pan, X.; Ru, P.; Garee, J.; Thomas, K.; Mohler, P.; Pancholi, P.; Jones, D.
10.1101/2021.01.12.426407 — genomics — Posted on 2021-01-15
2380 Clinically Relevant Gene Editing in Hematopoietic Stem Cells for the Treatment of Pyruvate Kinase Deficiency Hemolytic Anemia
Fananas Baquero, S.; Quintana-Bustamante, O.; Dever, D. P.; Alberquilla, O.; Sanchez, R.; Camarena, J.; Ojeda-Perez, I.; Dessy Rodriguez, M.; Turk, R.; Schubert, M. S.; Lopez Lorenzo, J. L.; Bianchi, P.; Bueren, J. A.; Behlke, M. A.; Porteus, M.; Segovia, J. C.
10.1101/2021.01.14.426673 — genetics — Posted on 2021-01-15
2382 Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2
Bertolin, G.; Alves-Guerra, M.-C.; Cheron, A.; Burel, A.; Prigent, C.; Le Borgne, R.; Tramier, M.
10.1101/2020.04.06.027896 — cell biology — Posted on 2021-01-15
2385 S. Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense
Gutierrez, S.; Fischer, J.; Ganesan, R.; Cildir, G.; Wolke, M.; Pessia, A.; Frommolt, P.; Desiderio, V.; Velagapudi, V.; Robinson, N.
10.1101/2021.01.14.426635 — microbiology — Posted on 2021-01-15
2386 The termite fungal cultivar Termitomyces combines diverse enzymes and oxidative reactions for plant biomass conversion
Schalk, F.; Gostincar, C.; Kreuzenbeck, N. B.; Schantz-Conlon, B.; Sommerwerk, E.; Rabe, P.; Burkhardt, I.; Krüger, T.; Kniemeyer, O.; Brakhage, A. A.; Gunde-Cimerman, N.; De Beer, W. Z.; Dickschat, J. S.; Poulsen, M.; Beemelmanns, C.
10.1101/2021.01.13.426627 — microbiology — Posted on 2021-01-15
2387 Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity
Han, G.; Dou, S.; Li, G.; Li, G.; HOU, C.; Zheng, Y.; Tang, L.; Gao, Y.; Mo, R.; Li, Y.; Wang, R.; Shen, B.; Zhang, J.
10.1101/2021.01.13.426507 — immunology — Posted on 2021-01-15
2388 Interhemispheric transfer of working memories
Brincat, S. L.; Donoghue, J. A.; Mahnke, M. K.; Kornblith, S.; Lundqvist, M.; Miller, E. K.
10.1101/2020.08.12.248203 — neuroscience — Posted on 2021-01-15
2389 Specific neuromodulation induced by alpha-based neurofeedback learning: A double-blind randomized study
Grosselin, F.; Breton, A.; Yahia-Cherif, L.; Wang, X.; Spinelli, G.; Hugueville, L.; Fossati, P.; Attal, Y.; Navarro, X.; Chavez, M.; George, N.
10.1101/2020.12.02.406173 — neuroscience — Posted on 2021-01-15
2391 Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
Casarotto, P. C.; Girych, M.; Fred, S. M.; Kovaleva, V.; Moliner, R.; Enkavi, G.; Biojone, C.; Cannarozzo, C.; Sahu, M. P.; Kaurinkoski, K.; Brunello, C.; Winkel, F.; Steinzeig, A.; Patil, S.; Vestrig, S.; Serchov, T.; Diniz, C. R.; Laukkanen, L.; Cardon, I.; Antila, H.; Rog, T.; Piepponen, T. P.; Bramham, C.; Normann, C.; Lauri, S.; Saarma, M.; Vattulainen, I.; Castren, E.
10.1101/757989 — neuroscience — Posted on 2021-01-15
2393 Characterisation and chemometric evaluation of 17 elements in ten seaweed species from Greenland
Kreissig, K. J.; Hansen, L. T.; Jensen, P. E.; Wegeberg, S.; Geertz-Hansen, O.; Sloth, J. J.
10.1101/2020.11.27.400861 — biochemistry — Posted on 2021-01-15
2395 Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Shwachman-Diamond syndrome
Lee, S.; Shin, C. H.; Lee, J.; Jeong, S. D.; Hong, C. R.; Kim, J.-D.; Kim, A.-R.; Son, S. J.; Kokhan, O.; Yoo, T.; Ko, J. S.; Sohn, Y. B.; Kim, O.-H.; Ko, J. M.; Cho, T.-J.; Wright, N. T.; Seong, J. K.; Jin, S.-W.; Kang, H. J.; Kim, H. H.; Choi, M.
10.1101/483362 — genetics — Posted on 2021-01-15
2396 MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging
Singh, P.; Fragoza, R.; Blengini, C. S.; Tran, T. N.; Pannafino, G.; Al-Sweel, N.; Schimenti, K.; Schindler, K.; Alani, E.; Yu, H.; Schimenti, J. C.
10.1101/2021.01.14.426654 — genetics — Posted on 2021-01-15
2397 High-quality SNPs from genic regions highlight introgression patterns among European white oaks (Quercus petraea and Q. robur).
Lang, T.; Abadie, P.; Leger, V.; Decourcelle, T.; Frigerio, J.-M.; Burban, C.; Bodenes, C.; Guichoux, E.; Le Provost, G.; Robin, C.; Tani, N.; Leger, P.; Lepoittevin, C.; El Mujtar, V. A.; Hubert, F.; Tibbits, J.; Paiva, J.; Franc, A.; Raspail, F.; Mariette, S.; Reviron, M.-P.; Plomion, C.; Kremer, A.; Desprez-Loustau, M.-L.; Garnier-Gere, P.
10.1101/388447 — evolutionary biology — Posted on 2021-01-15
2400 Novel Thyroid-Specific Autoantibodies in Patients with Immune-Related Adverse Events Involving the Thyroid Gland
Yamauchi, I.; Yasoda, A.; Hakata, T.; Yamashita, T.; Hirota, K.; Ueda, Y.; Fujii, T.; Taura, D.; Sone, M.; Inagaki, N.
10.1101/2021.01.14.426670 — immunology — Posted on 2021-01-15
2401 Essential Role of Placenta Derived Interferon Stimulated Gene 20 Against ZIKA Virus Infection
Ding, J.; Aldo, P.; Roberts, C. M.; Stabach, P. R.; Liu, H.; You, Y.; Qiu, X.; Jeong, J.; Maxwell, A.; Lindenbach, B. D.; Braddock, D. T.; Liao, A.; Gil, M.
10.1101/2021.01.13.426624 — immunology — Posted on 2021-01-15
2404 Crosstalk between H2A variant-specific modifications impacts vital cell functions
Schmuecker, A.; Lei, B.; Lorkovic, Z.; Capella, M.; Braun, S. J.; Bourguet, P.; Mathieu, O.; Mechtler, K.; Berger, F.
10.1101/2021.01.14.426637 — synthetic biology — Posted on 2021-01-15
2406 Optimisation and validation of a sensitive bioanalytical method for niclosamide.
Arshad, U.; Pertinez, H.; Box, H.; Tatham, L.; Rajoli, R.; Neary, M.; Sharp, J.; Valentijn, A.; Hobson, J.; Unsworth, C.; Dwyer, A.; Savage, A.; McDonald, T.; Rannard, S.; Curley, P.; Owen, A.
10.1101/2021.01.13.426426 — pharmacology and toxicology — Posted on 2021-01-15
2408 Structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in Nucleotide Excision Repair
van Eeuwen, T.; Shim, Y.; Kim, H. J.; Zhao, T.; Basu, S.; Kaplan, C. D.; Garcia, B. A.; Min, J. H.; Murakami, K.
10.1101/2021.01.14.426755 — biophysics — Posted on 2021-01-15
2409 Structure of Cystathionine β-Synthase from Toxoplasma gondii, a key enzyme in its H2S production machinery.
Fernandez-Rodriguez, C.; Oyenarte, I.; Conter, C.; Gonzalez-Recio, I.; Nunez-Franco, R.; Gil-Pitarch, C.; Quintana, I.; Jimenez-Oses, G.; Dominici, P.; Martinez-Chantar, M. L.; Astegno, A.; Martinez-Cruz, L. A.
10.1101/2021.01.15.426774 — biochemistry — Posted on 2021-01-15
2411 ATRX alteration contributes to tumor growth and immune escape in pleomorphic sarcomas
Darmusey, L.; Perot, G.; Thebault, N.; Le Guellec, S.; Desplat, N.; Gaston, L.; Delespaul, L.; Lesluyes, T.; Darbo, E.; Gomez-Brouchet, A.; Richard, E.; Baud, J.; Leroy, L.; Coindre, J. M.; Blay, J.-Y.; Chibon, F.
10.1101/2020.10.23.352112 — cancer biology — Posted on 2021-01-15
2412 Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis
Miguel, V.; Tituana, J.; Herrero, J. I.; Herrero, L.; Serra, D.; Cuevas, P.; Barbas, C.; Rodriguez-Puyol, D.; Marquez-Exposito, L.; Ruiz-Ortega, M.; Castillo, C.; Sheng, X.; Susztak, K.; Ruiz-Canela, M.; Salas-Salvado, J.; Martinez Gonzalez, M. A.; Ortega, S.; Ramos, R.; Lamas, S.
10.1101/2020.02.18.952440 — biochemistry — Posted on 2021-01-15
2413 The Contributions from the Progenitor Genomes of the Mesopolyploid Brassiceae are Evolutionarily Distinct but Functionally Compatible
Hao, Y.; Mabry, M. E.; Edger, P.; Freeling, M.; Zheng, C.; Jin, L.; VanBuren, R.; Colle, M.; An, H.; Abrahams, R. S.; Washburn, J. D.; Qi, X.; Barry, K.; Daum, C.; Shu, S.; Schmutz, J.; Sankoff, D.; Barker, M. S.; Lyons, E.; Pires, J. C.; Conant, G. C.
10.1101/2020.08.10.245258 — genomics — Posted on 2021-01-15
2415 Functional strain redundancy and persistent phage infection in Swiss hard cheese starter cultures
Somerville, V.; Berthoud, H.; Schmid, R. S.; Bachmann, H.-P.; Meng, H. Y.; Fuchsmann, P.; von Ah, U.; Engel, P.
10.1101/2021.01.14.426499 — microbiology — Posted on 2021-01-15
2420 The impact of age and education on phonemic and semantic verbal fluency: Behavioral and fMRI correlates
Fonseca, R. P.; Marcotte, K.; Hubner, L. C.; ZIMMERMANN, N.; Netto, T. M.; Bizzo, B.; Döring, T.; Landeira-Fernandez, J.; Gasparetto, E. L.; Joanette, Y.; Ansaldo, A. I.
10.1101/2021.01.14.426642 — neuroscience — Posted on 2021-01-14
2421 Two novel loci underlie natural differences in Caenorhabditis elegans macrocyclic lactone responses
Andersen, E. C.; Evans, K. S.; Wit, J.; Stevens, L.; Hahnel, S. R.; Rodriguez, B.; Park, G.; Zamanian, M.; Brady, S. C.; Chao, E.; Introcaso, K.; Tanny, R. E.
10.1101/2021.01.14.426644 — genetics — Posted on 2021-01-14
2428 Enhancers regulate polyadenylation site cleavage and control 3'UTR isoform expression
Kwon, B.; Fansler, M. M.; Patel, N. D.; Lee, S.-H.; Lee, J.; Ma, W.; Mayr, C.
10.1101/2020.08.17.254193 — biochemistry — Posted on 2021-01-14
2430 The epigenetic eraser LSD1 lies at the apex of a reversible erythroid to myeloid cell fate decision
Yu, L.; Myers, G.; Ku, C.-J.; Schneider, E.; Wang, Y.; Singh, S.; Jearawiriyapaisarn, N.; White, A.; Moriguchi, T.; Khoriaty, R.; Yamamoto, M.; Rosenfeld, M. G.; Pedron, J.; Bushweller, J. H.; Lim, K.-C.; Engel, J. D.
10.1101/2021.01.13.426552 — developmental biology — Posted on 2021-01-14
2431 The TPLATE subunit is essential for structural assembly of the endocytic TSET complex
Yperman, K.; Wang, J.; Eeckhout, D.; Winkler, J.; Vu, L.; Vandorpe, M.; Grones, P.; Mylle, E.; Kraus, M.; Merceron, R.; Nolf, J.; Mor, E.; De Bruyn, P.; Loris, R.; Potocky, M.; Savvides, S. N.; De Rybel, B.; De Jaeger, G.; Van Damme, D.; Pleskot, R.
10.1101/2020.08.13.249276 — cell biology — Posted on 2021-01-14
2433 Role of the mobilome in the global dissemination of the carbapenem resistance gene blaNDM
Acman, M.; Wang, R.; van Dorp, L.; Shaw, L. P.; Wang, Q.; Luhmann, N.; Yuyao, Y.; Sun, S.; Chen, H.; Wang, H.; Balloux, F.
10.1101/2021.01.14.426698 — microbiology — Posted on 2021-01-14
2434 Structural mechanism of CARD8 regulation by DPP9
Sharif, H.; Hollingsworth, L. R.; Griswold, A. R.; Hsiao, J. C.; Wang, Q.; Bachovchin, D. A.; Wu, H.
10.1101/2021.01.13.426575 — immunology — Posted on 2021-01-14
2437 The structural connectome constrains fast brain dynamics
Sorrentino, P.; Seguin, C.; Rucco, R.; Liparoti, M.; Troisi Lopez, E.; Bonavita, S.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.; Zalesky, A.
10.1101/2020.11.25.393017 — neuroscience — Posted on 2021-01-14
2438 Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation
Eriksson, D.; Schneider, A.; Thirumalai, A.; Alyahyay, M.; de la Crompe, B.; Sharma, K.; Ruther, P.; Diester, I.
10.1101/2021.01.13.426504 — neuroscience — Posted on 2021-01-14
2439 Natural variations in the P-type ATPase heavy metal transporter ZmCd1 controlling cadmium accumulation in maize grains
Tang, B.; Luo, M.; Zhang, Y.; Li, J.; Guo, H.; Song, W.; Zhang, R.; Feng, Z.; Kong, M.; Li, H.; Cao, Z.; Lu, X.; Li, D.; Zhang, J.; Wang, R.; Wang, Y.; Chen, Z.; Zhao, Y.; Zhao, J.
10.1101/2021.01.13.426291 — plant biology — Posted on 2021-01-14
2440 Recombinant adenovirus causes prolonged mobilization of macrophages in the anterior chamber of mice
Meyer, K. J.; Pellack, D.; Hedberg-Buenz, A. J.; Pomernackas, N.; Soukup, D.; Wang, K.; Fingert, J. H.; Anderson, M. G.
10.1101/2021.01.13.426423 — physiology — Posted on 2021-01-14
2441 MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging
Fragoza, R.; Blengini, C. S.; Tran, T. N.; Pannafino, G.; Al-Sweel, N.; Schimenti, K.; Schindler, K.; Alani, E.; Yu, H.; Schimenti, J. C.
10.1101/2021.01.14.426654 — genetics — Posted on 2021-01-14
2443 Evolution of primate protomusicality via locomotion
Schruth, D. M.; Templeton, C. N.; Holman, D. J.; Smith, E. A.
10.1101/2020.12.29.424766 — evolutionary biology — Posted on 2021-01-14
2444 Mutagenesis Mapping of RNA Structures within the Foot-and-Mouth Disease Virus Genome Reveals Functional Elements Localised in the Polymerase (3Dpol) Encoding Region.
Lasecka-Dykes, L.; Tulloch, F.; Simmonds, P.; Luke, G. A.; Ribeca, P.; Gold, S.; Knowles, N. J.; Wright, C. F.; Wadsworth, J.; Azhar, M.; King, D. P.; Tuthill, T. J.; Jackson, T.; Ryan, M. D.
10.1101/2021.01.04.425359 — evolutionary biology — Posted on 2021-01-14
2446 The effect of activity, energy use, and species identity on environmental DNA shedding of freshwater fish
Thalinger, B.; Rieder, A.; Teuffenbach, A.; Putz, Y.; Schwerte, T.; Wanzenboeck, J.; Traugott, M.
10.1101/2020.10.28.359653 — ecology — Posted on 2021-01-14
2447 Scaling up biodiversity ecosystem functioning relationships: the role of environmental heterogeneity in space and time
Thompson, P. L.; Kefi, S.; Zelnik, Y. R.; Dee, L. E.; Wang, S.; de Mazancourt, C.; Loreau, M.; Gonzalez, A.
10.1101/2020.11.04.367250 — ecology — Posted on 2021-01-14
2448 The Necroptosis Effector MLKL drives Small Extracellular Vesicle Release and Tumour Growth in Glioblastoma
Andre-Gregoire, G.; Douanne, T.; Thys, A.; Maghe, C.; Jacobs, K. A.; Ballu, C.; Trillet, K.; Busnelli, I.; Hyenne, V.; GOETZ, J. G.; Bidere, N.; Gavard, J.
10.1101/2021.01.12.426398 — cell biology — Posted on 2021-01-14
2451 Exo-beta-N-acetylmuramidase NamZ of Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases
Müller, M.; Calvert, M.; Hottmann, I.; Kluj, R. M.; Teufel, T.; Balbuchta, K.; Engelbrecht, A.; Selim, K. A.; Xu, Q.; Borisova, M.; Titz, A.; Mayer, C.
10.1101/2021.01.10.425899 — microbiology — Posted on 2021-01-14
2452 High-content imaging to phenotype antimicrobial effects on individual bacteria at scale
Sridhar, S.; Forrest, S.; Warne, B.; Maes, M.; Baker, S.; Dougan, G.; Bartholdson Scott, J.
10.1101/2021.01.11.426307 — microbiology — Posted on 2021-01-14
2453 Cell surface hydrophobicity determines Pseudomonas aeruginosa aggregate assembly
Azimi, S.; Thomas, J.; Cleland, S.; Curtis, J. E.; Goldberg, J. B.; Diggle, S. P.
10.1101/2021.01.14.426723 — microbiology — Posted on 2021-01-14
2454 Nanobody Mediated Macromolecular Crowding Induces Membrane Fission and Remodeling in the African Trypanosome
Hempelmann, A.; Hartleb, L.; Van Straaten, M.; Hashemi, H.; Zeelen, J. P.; Papavasiliou, F. N.; Engstler, M.; Stebbins, C. E.; Jones, N. G.
10.1101/2021.01.13.426364 — microbiology — Posted on 2021-01-14
2457 Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination
Herskovitz, J.; Hasan, M.; Patel, M.; Blomberg, W. R.; Cohen, J. D.; Machhi, J.; Stein, D.; Schroder, E. A.; McMillan, J.; Gurumurthy, C.; Kevadiya, B. D.; Gendelman, H. E.
10.1101/2021.01.14.426544 — microbiology — Posted on 2021-01-14
2458 Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation
Lioy, V.; Lorenzi, J.-N.; Najah, S.; Poinsignon, T.; Leh, H.; Saulnier, C.; Aigle, B.; Lautru, S.; Thibessard, A.; Lespinet, O.; Leblond, P.; Jaszczyszyn, Y.; Gorrichon, K.; Varoquaux, N.; Junier, I.; Boccard, F.; Pernodet, J.-L.; Bury-Mone, S. G.
10.1101/2020.12.09.415976 — microbiology — Posted on 2021-01-14
2459 Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations
Swanson, O.; Rhodes, B.; Wang, A.; Shi-Mao, X.; Parks, R.; Sanzone, A.; Louder, M. K.; Lin, B. C.; Doria-Rose, N.; Bonsignori, M.; Saunders, K. O.; Wiehe, K.; Haynes, B. F.; Azoitei, M. L.
10.1101/2021.01.04.425252 — immunology — Posted on 2021-01-14
2460 Global transcriptomics reveals specialized roles for splicing regulatory proteins in the macrophage innate immune response
West, K. O.; Wagner, A. R.; Scott, H. M.; Vail, K. J.; Carter, K. E.; Watson, R. O.; Patrick, K. L.
10.1101/2020.12.06.413690 — immunology — Posted on 2021-01-14
2461 SARS-CoV-2 spike protein arrested in the closed state induces potent neutralizing responses
Carnell, G. W.; Ciazynska, K. A.; Wells, D. A.; Xiong, X.; Aguinam, E. T.; McLaughlin, S. H.; Mallery, D.; Ebrahimi, S.; Ceron-Gutierrez, L.; James, L. C.; Doffinger, R.; Heeney, J. L.; Briggs, J. A. G.
10.1101/2021.01.14.426695 — immunology — Posted on 2021-01-14
2462 Dysregulated functional and metabolic response in multiple sclerosis patient macrophages correlate with a more inflammatory state, reminiscent of trained immunity
Fransson, J.; Bachelin, C.; Deknuydt, F.; Ichou, F.; Guillot-Noel, L.; Ponnaiah, M.; Gloaguen, A.; Maillart, E.; Stankoff, B.; Tenenhaus, A.; Mochel, F.; Fontaine, B.; Louapre, C.; Zujovic, V.
10.1101/2021.01.13.426327 — neuroscience — Posted on 2021-01-14
2463 Role of 5-HT2C receptors in zebrafish alarm reactions and post-exposure behavior
do Carmo Silva, R. X.; do Nascimento, B. G.; Gomes, G. C. V.; Holanda da Silva, N. A.; Pinheiro, J. S.; da Silva Chaves, S. N.; Pimentel, A. F. N.; Costa, B. P. D.; Herculano, A. M.; Lima-Maximino, M.; Maximino, C.
10.1101/2020.10.04.324202 — neuroscience — Posted on 2021-01-14
2465 Differential regulation of progranulin derived granulin peptides
Zhang, T.; Du, H.; Nunez Santos, M.; Wu, X.; Reinheckel, T.; Hu, F.
10.1101/2021.01.08.425959 — neuroscience — Posted on 2021-01-14
2466 Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron micro-tomography and volume electron microscopy
Bosch, C.; Ackels, T.; Pacureanu, A.; Zhang, Y.; Peddie, C. J.; Berning, M.; Rzepka, N.; Zdora, M.-C.; Whiteley, I.; Storm, M.; Bonnin, A.; Rau, C.; Margrie, T.; Collinson, L.; Schaefer, A. T.
10.1101/2021.01.13.426503 — neuroscience — Posted on 2021-01-14
2467 Integrated neural dynamics for behavioral decisions and attentional control in the prefrontal cortex
Erez, Y.; Kadohisa, M.; Petrov, P.; Sigala, N.; Buckley, M. J.; Kusunoki, M.; Duncan, J.
10.1101/2020.05.06.080325 — neuroscience — Posted on 2021-01-14
2469 Inside-out regulation of E-cadherin conformation and adhesion
Koirala, R.; Priest, A. V.; Yen, C.-F.; Cheah, J. S.; Pannekoek, W.-J.; Gloerich, M.; Yamada, S.; Sivasankar, S.
10.1101/2020.05.02.074187 — biophysics — Posted on 2021-01-14
2470 An Effector Index to Predict Causal Genes at GWAS Loci
Forgetta, V.; Jiang, L.; Vulpescu, N. A.; Hogan, M. S.; Chen, S.; Morris, J. A.; Grinek, S.; Benner, C.; Jang, D.-K.; Hoang, Q.; Burtt, N.; Flannick, J. A.; Mccarthy, M. I.; Fauman, E.; Greenwood, C. M.; Maurano, M. T.; Richards, J. B.
10.1101/2020.06.28.171561 — bioinformatics — Posted on 2021-01-14
2473 Mutation rates and selection on synonymous mutations in SARS-CoV-2
De Maio, N.; Walker, C. R.; Turakhia, Y.; Lanfear, R.; Corbett-Detig, R.; Goldman, N.
10.1101/2021.01.14.426705 — evolutionary biology — Posted on 2021-01-14
2477 Natural SARS-CoV-2 infection in kept ferrets, Spain
Gortazar, C.; Barroso-Arevalo, S.; Ferreras, E.; Isla, J.; de la Fuente, G.; Rivera, B.; Dominguez, L.; de la Fuente, J.; Vizcaino, J. M.
10.1101/2021.01.14.426652 — microbiology — Posted on 2021-01-14
2479 An activity-based labelling method for the detection of ammonia and methane-oxidizing bacteria.
Sakoula, D.; Smith, G. J.; Frank, J.; Mesman, R. R.; Kop, L. F. M.; Jetten, M. S. M.; van Kessel, M. A. H. J.; Luecker, S.
10.1101/2021.01.14.426632 — microbiology — Posted on 2021-01-14
2480 An enhancer sequence in the intrinsically disordered region of the essential cell division protein FtsZ promotes conformation-guided substrate processing by ClpXP in Escherichia coli
Viola, M. G.; Perdikari, T. M.; Trebino, C.; Rahmani, N.; Mathews, K. L.; Pena, C. M.; Chua, X. Y.; Xuan, B.; LaBreck, C. J.; Fawzi, N. L.; Camberg, J. L.
10.1101/2021.01.14.426688 — microbiology — Posted on 2021-01-14
2483 Functional strain redundancy and persistent phage infection in Swiss hard cheese starter cultures
Somerville, V.; Berthoud, H.; Schmid, R. S.; Bachmann, H.-P.; Meng, H. Y.; Fuchsmann, P.; von Ah, U.; Engel, P.
10.1101/2021.01.14.426499 — microbiology — Posted on 2021-01-14
2484 Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue
Mukadam, A. S.; Miller, L. V. C.; Durrant, C. S.; Vaysburd, M. J.; Katsinelos, T.; Tuck, B. J.; Sanford, S.; Sheppard, O.; Knox, C.; Cheng, S.; James, L. C.; Coleman, M. P.; McEwan, W. A.
10.1101/2021.01.13.426340 — neuroscience — Posted on 2021-01-14
2486 Post-transcriptional gene regulation by the RNA binding protein IGF2BP3 is critical for MLL-AF4 mediated leukemogenesis
Tran, T. M.; Philipp, J.; Bassi, J.; Nibber, N.; Draper, J.; Lin, T.; Palanichamy, J. K.; Jaiswal, A. K.; Silva, O.; Paing, M.; King, J.; Katzman, S.; Sanford, J. R.; Rao, D. S.
10.1101/2020.12.20.423624 — cancer biology — Posted on 2021-01-14
2488 Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation
Nishikawa, T.; Chang, C. Y.; Tai, J. A.; Hayashi, H.; Sun, J.; Torii, S.; Ono, C.; Matsuura, Y.; Ide, R.; Mineno, J.; Sasai, M.; Yamamoto, M.; Nakagami, H.; Yamashita, K.
10.1101/2021.01.13.426436 — immunology — Posted on 2021-01-14
2489 Spatial drivers and pre-cancer populations collaborate with the microenvironment in untreated and chemo-resistant pancreatic cancer
Cui Zhou, D.; Jayasinghe, R. G.; Herndon, J. M.; Storrs, E.; Mo, C.-K.; Wu, Y.; Fulton, R. S.; Wyczalkowski, M. A.; Fronick, C. C.; Fulton, L. A.; Thammavong, L.; Sato, K.; Zhu, H.; Sun, H.; Wang, L.-B.; Li, Y.; Zuo, C.; McMichael, J. F.; Davies, S. R.; Appelbaum, E. L.; Robbins, K. J.; Chasnoff, S. E.; Yang, X.; Liu, R.; Reeb, A. N.; Wendl, M. C.; Oh, C.; Serasanambati, M.; Lal, P.; Varghese, R.; Mashl, J. R.; Ponce, J.; Terekhanova, N. V.; Naser Al Deen, N.; Yao, L.; Wang, F.; Chen, L.; Schnaubelt, M.; Puram, S. V.; Kim, A. H.; Song, S.-K.; Shoghi, K. I.; Ju, T.; Hawkins, W. G.; Chen, K.; Ch
10.1101/2021.01.13.426413 — cancer biology — Posted on 2021-01-14
2493 Constitutive high expression of NOXA sensitizes human embryonic stem cells for rapid cell death
Basundra, R.; Kapoor, S.; Hollville, E.; Kiapour, N.; Lopez, A. B.; Melchiorre, N. M.; Deshmukh, M.
10.1101/2021.01.13.426566 — cell biology — Posted on 2021-01-14
2495 Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2
Palmer, M. V.; Martins, M.; Falkenberg, S.; Buckley, A. C.; Caserta, L. C.; Mitchell, P. K.; Cassmann, E.; Rollins, A.; Zylich, N. C.; Renshaw, R. W.; Guarino, C.; Wagner, B.; Lager, K.; Diel, D. G.
10.1101/2021.01.13.426628 — microbiology — Posted on 2021-01-14
2496 A highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative elicits high titers of neutralizing antibodies
Malladi, S. K.; Patel, U. R.; Singh, R.; Pandey, S.; Kumar, S.; Gayathri, S.; Kalita, P.; Pramanick, I.; Reddy, P.; Girish, N.; Upadhyaya, A.; Khan, M. S.; Bhat, M.; Mani, S.; Bhattacharyya, S.; Siddiqui, S.; Tyagi, A.; Jha, S.; Pandey, R.; Dutta, S.; Ringe, R. P.; Varadarajan, R.
10.1101/2021.01.13.426626 — microbiology — Posted on 2021-01-14
2497 N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
McCallum, M.; De Marco, A.; Lempp, F.; Tortorici, M. A.; Pinto, D.; Walls, A. C.; Beltramello, M.; Chen, A.; Liu, Z.; Zatta, F.; Zepeda, S.; di Iulio, J.; Bowen, J. E.; Montiel-Ruiz, M.; Zhou, J.; Rosen, L.; Bianchi, S.; Guarino, B.; Silacci Fregni, C.; Abdelnabi, R.; Foo, S.-Y. C.; Rothlauf, P. W.; Bloyet, L.-M.; Benigni, F.; Cameroni, E.; Neyts, J.; Riva, A.; Snell, G.; Telenti, A.; Whelan, S. P.; Virgin, H. W.; Corti, D.; Pizzuto, M. S.; Veesler, D.
10.1101/2021.01.14.426475 — immunology — Posted on 2021-01-14
2498 Serotonergic Effects on Interoception
Livermore, J. J. A.; Holmes, C. L.; Moga, G.; Adamatzky, K.; Critchley, H.; Garfinkel, S.; Campbell-Meiklejohn, D.
10.1101/2020.08.28.262550 — neuroscience — Posted on 2021-01-14
2503 The Amot/Integrin protein complex transmits mechanical forces required for vascular expansion
Zhang, Y.; Zhang, Y.; Kameishi, S.; Barutello, G.; Zheng, Y.; Tobin, N. P.; Nicosia, J.; Hennig, K.; Chiu, D. K.-C.; Balland, M.; Barker, T. H.; Cavallo, F.; Holmgren, L.
10.1101/2021.01.14.426638 — cell biology — Posted on 2021-01-14
2504 FOXO1 and FOXO3 cooperatively regulate innate lymphoid cell development
Thanh, T. L.; Norskov, J.; Perez, L. P.; Kharazi, S.; Krstic, A.; Meinke, S.; Schmied, L.; Frengen, N.; Heshmati, Y.; Kierczak, M.; Bouderlique, T.; Wagner, A.; Gustafsson, C.; Chambers, B.; Achour, A.; Kutter, C.; Hoglund, P.; Mansson, R.; Kadri, N.
10.1101/2021.01.13.426512 — cell biology — Posted on 2021-01-14
2506 A convergent structure-function substrate of cognitive imbalances in autism
Hong, S.-J.; Laurent, M.; Park, B.-Y.; Benkarim, O.; Valk, S. L.; Paquola, C.; Lariviere, S.; Vos de Wael, R.; Degre-Pelletier, J.; Soulieres, I.; Ramphal, B.; Margolis, A.; Milham, M.; Di Martino, A.; Bernhardt, B.
10.1101/2021.01.14.426284 — neuroscience — Posted on 2021-01-14
2507 Proximal and Distal Nephron-specific Adaptation to Furosemide
Krauson, A. J.; Schaffert, S.; Walczak, E. M.; Nizar, J. M.; Holdgate, G. M.; Iyer, S.; Elsayed, R.; Gaudet, A.; Khatri, P.; Bhalla, V.
10.1101/2021.01.12.426306 — physiology — Posted on 2021-01-14
2514 Significant East Asian affinity of Chinese Hui genomic structure suggesting their predominant cultural diffusion model in the genetic formation process
Liu, Y.; Yang, J.; Tang, R.; Yuan, D.; Yang, Y.; Wang, P.; Deng, S.; Zeng, S.; Li, H.; Chen, G.; Zou, X.; Wang, M.; He, G.
10.1101/2021.01.12.426452 — genetics — Posted on 2021-01-14
2518 Uneven declines between corals and cryptobenthic fish symbionts from multiple disturbances
Froehlich, C. Y. M.; Klanten, O. S.; Hing, M. L.; Dowton, M.; Wong, M. Y. L.
10.1101/2021.01.13.426488 — ecology — Posted on 2021-01-14
2520 In vivo multi-parametric manganese-enhanced MRI for detecting senile plaques in rodent models of Alzheimer's disease
Kim, E.; Di Censo, D.; Baraldo, M.; Simmons, C.; Rosa, I.; Randall, K.; Ballard, C.; Dickie, B. R.; Williams, S. C.; Killick, R.; Cash, D.
10.1101/2021.01.12.426392 — neuroscience — Posted on 2021-01-14
2525 MiDAS - Meaningful Immunogenetic Data at Scale
Migdal, M.; Ruan, D. F.; Forrest, W. F.; Horowitz, A.; Hammer, C.
10.1101/2021.01.12.425276 — bioinformatics — Posted on 2021-01-14
2528 Dimensionality reduction by UMAP reinforces sample heterogeneity analysis in bulk transcriptomic data
Yang, Y.; Sun, H.; Zhang, Y.; Zhang, T.; Gong, J.; Wei, Y.; Duan, Y.-G.; Shu, M.; Yang, Y.; Wu, D.; Yu, D.
10.1101/2021.01.12.426467 — bioinformatics — Posted on 2021-01-14
2530 Low generalizability of polygenic scores in African populations due to genetic and environmental diversity
Majara, L.; Kalungi, A.; Koen, N.; Zar, H.; Stein, D. J.; Kinyanda, E.; Atkinson, E. G.; Martin, A. R.
10.1101/2021.01.12.426453 — genetics — Posted on 2021-01-14
2534 DotMotif: An open-source tool for connectome subgraph isomorphism search and graph queries
Matelsky, J. K.; Reilly, E. P.; Johnson, E. C.; Stiso, J.; Bassett, D. S.; Wester, B. A.; Gray-Roncal, W.
10.1101/2020.06.08.140533 — neuroscience — Posted on 2021-01-14
2537 Evolution of primate protomusicality via locomotion
Schruth, D. M.; Templeton, C. N.; Holman, D. J.; Smith, E. A.
10.1101/2020.12.29.424766 — evolutionary biology — Posted on 2021-01-14
2540 Integrated multi-omics analysis reveals common and distinct dysregulated pathways for genetic subtypes of Frontotemporal Dementia
Menden, K.; Francescatto, M.; Niyma, T.; Blauwendraat, C.; Dhingra, A.; Castillo Lizardo, M.; Fernandes, N.; Kaurani, L.; Kronenberg-Versteeg, D.; Atarsu, B.; Sadikoglou, E.; Borroni, B.; Rodriguez Nieto, S.; Simon Sanchez, J.; Fischer, A.; Craig, D. W.; Neumann, M.; Bonn, S.; Rizzu, P.; Heutink, P.
10.1101/2020.12.01.405894 — neuroscience — Posted on 2021-01-14
2543 Putative mobilized colistin resistance genes in the human gut microbiome
Andrade, B. G.; Goris, T.; Afli, H.; Coutinho, F. H.; Davila, A. M. R.; Cuadrat, R. R. d. C.
10.1101/2020.12.31.424960 — bioinformatics — Posted on 2021-01-14
2545 Adolescent Alcohol Binge-Drinking compromises behaviors during adulthood without triggering neuroinflammation
Van Hees, L.; Didone, V.; Charlet-Briart, M.; Van Ingelgom, T.; Alexandre, A.; Quertemont, E.; Nguyen, L.; Laguesse, S.
10.1101/2020.08.11.245878 — animal behavior and cognition — Posted on 2021-01-14
2546 Functional annotation of human long noncoding RNAs using chromatin conformation data
Agrawal, S.; Alam, T.; Koido, M.; Kulakovskiy, I. V.; Severin, J.; Abugessaisa, I.; Buyan, A.; Dostie, J.; Itoh, M.; Kondo, N.; Li, Y.; Mendez, M.; Ramilowski, J. A.; Yagi, K.; Yasuzawa, K.; Yip, C. W.; Okazaki, Y.; Hoffman, M. M.; Strug, L.; Hon, C.-C.; Terao, C.; Kasukawa, T.; Makeev, V. J.; Shin, J. W.; Carninci, P.; de Hoon, M. J. L.
10.1101/2021.01.13.426305 — genomics — Posted on 2021-01-14
2547 The genetic architecture of human cortical folding
van der Meer, D.; Kaufmann, T.; Shadrin, A. A.; Makowski, C.; Frei, O.; Roelfs, D.; Monereo Sanchez, J.; Linden, D. E.; Rokicki, J.; de Leeuw, C.; Thompson, W. K.; Loughnan, R. J.; Fan, C. C.; Westlye, L. T.; Andreassen, O. A.; Dale, A. M.
10.1101/2021.01.13.426555 — genomics — Posted on 2021-01-14
2549 Model-based genotype and ancestry estimation for potential hybrids with mixed-ploidy
Shastry, V.; Adams, P. E.; Lindtke, D.; Mandeville, E. G.; Parchman, T. L.; Gompert, Z.; Buerkle, C. A.
10.1101/2020.07.31.231514 — genetics — Posted on 2021-01-14
2550 Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids
Xavier, M.; Kyriazi, M.; Lanham, S.; Alexaki, K.; El-Sagheer, A.; Brown, T.; Kanaras, A.; Oreffo, R. O. C.
10.1101/2019.12.19.882563 — cell biology — Posted on 2021-01-14
2554 The timing and impact of psychiatric, cognitive and motor abnormalities in Huntington's disease
McAllister, B.; Gusella, J. F.; Landwehrmeyer, G. B.; Lee, J.-M.; MacDonald, M. E.; Orth, M.; Rosser, A. E.; Williams, N. M.; REGISTRY Investigators of the European Huntington's disease network, ; Holmans, P.; Jones, L.; Massey, T. H.
10.1101/2020.05.26.116798 — neuroscience — Posted on 2021-01-14
2555 iNetModels 2.0: an interactive visualization and database of multi-omics data
Arif, M.; Zhang, C.; Li, X.; Güngör, C.; Cakmak, B.; Arslantürk, M.; Tebani, A.; Özcan, B.; Subas, O.; Zhou, W.; Piening, B.; Turkez, H.; Fagerberg, L.; Price, N.; Hood, L.; Snyder, M.; Nielsen, J.; Uhlen, M.; Mardinoglu, A.
10.1101/662502 — bioinformatics — Posted on 2021-01-14
2557 Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70
Kemp, S.; Harvey, W.; Datir, R.; Collier, D.; Ferreira, I.; Meng, B.; COVID-19 Genomics UK (COG-UK) consortium, ; Carabelii, A.; Robertson, D. L.; Gupta, R. K.
10.1101/2020.12.14.422555 — microbiology — Posted on 2021-01-14
2558 Cutibacterium acnes clonal complexes display various growth rates in blood culture bottles used for diagnosing orthopedic device related infections
El Sayed, F.; Camernik, P.; Roux, A.-L.; Papst, L.; bauer, t.; Nkam, L.; Sivadon-Tardy, V.; Noussair, L.; Herrmann, J.-L.; Gaillard, J.-L.; Jeverica, S.; Rottman, M.
10.1101/2021.01.11.426311 — microbiology — Posted on 2021-01-14
2559 High-throughput Identification of Eukaryotic Parasites and Arboviruses in Mosquitoes
Cannon, M. V.; Bogale, H. N.; Bhalerao, D.; Keita, K.; Camara, D.; Barry, Y.; Keita, M.; Coulibaly, D.; Kone, A. K.; Doumbo, O. K.; Thera, M. A.; Plowe, C. V.; Travassos, M. A.; Irish, S. R.; Yeroshefsky, J.; Dorothy, J.; Prendergast, B.; St. Laurent, B.; Fritz, M. L.; Serre, D.
10.1101/2021.01.12.426319 — microbiology — Posted on 2021-01-14
2560 Lymphotoxin β receptor: A crucial role in innate and adaptive immune responses against Toxoplasma gondii
Tersteegen, A. K.; Sorg, U. R.; Virgen-Slane, R.; Helle, M.; Petzsch, P.; Dunay, I. R.; Köhrer, K.; Degrandi, D.; Ware, C. F.; Pfeffer, K.
10.1101/2021.01.11.426315 — immunology — Posted on 2021-01-14
2563 Standardized quality control workflow to evaluate the reproducibility and differentiation potential of human iPSCs into neurons
Chen, C. X.- Q.; Abdian, N.; Maussion, G.; Thomas, R. A.; Demirova, I.; Cai, E.; Tabatabaei, M.; Beitel, L. K.; Karamchandani, J.; Fon, E. A.; Durcan, T. M.
10.1101/2021.01.13.426620 — cell biology — Posted on 2021-01-14
2564 Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex
Koike, Y.; Sugai, A.; Hara, N.; Ito, J.; Yokoseki, A.; Ishihara, T.; Yamagishi, T.; Tsuboguchi, S.; Tada, M.; Ikeuchi, T.; Kakita, A.; Onodera, O.
10.1101/2021.01.13.426599 — molecular biology — Posted on 2021-01-14
2568 A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment
Alcaraz, L. B.; Mallavialle, A.; David, T.; Derocq, D.; Delolme, F.; Dieryckx, C.; Boissiere-Michot, F.; Simony-Lafontaine, J.; Du Manoir, S.; Huesgen, P.; Overall, C. M.; Tartare-Deckert, S.; Jacot, W.; Chardes, T.; Guiu, S.; Roger, P.; Reinheckel, T.; Moali, C.; Liaudet-Coopman, E.
10.1101/2020.10.22.350082 — cancer biology — Posted on 2021-01-14
2577 Prevalence of floating toe and its relationship with static postural stability in children: The Yamanashi adjunct study of the Japan Environment and Childrens Study (JECS-Y)
Fujimaki, T.; Wako, M.; Koyama, K.; Furuya, N.; Shinohara, R.; Otawa, S.; Kobayashi, A.; Horiuchi, S.; Kushima, M.; Yamagata, Z.; Haro, H.
10.1101/2021.01.13.426517 — physiology — Posted on 2021-01-13
2579 Evolutionary Perspective And Expression Analysis Of Intronless Genes Highlight The Conservation On Their Regulatory Role
Avina-Padilla, K.; Ramirez Rafael, J. A.; Herrera-Oropeza, G. E.; Muley, V.; Valdivia, D.; Diaz Valenzuela, E.; Garcia-Garcia, A.; Varela-Echavarria, A.; Hernandez-Rosales, M.
10.1101/2021.01.13.426573 — evolutionary biology — Posted on 2021-01-13
2581 Propranolol promotes bone formation and limits resorption through novel mechanisms during anabolic parathyroid hormone treatment in female C57BL/6J mice
Treyball, A.; Bergeron, A. C.; Brooks, D. J.; Langlais, A. L.; Hashmi, H.; Nagano, K.; Barlow, D.; Nevola, K. T.; Houseknecht, K. L.; Baron, R.; Bouxsein, M.; Guntur, A. R.; Motyl, K. J.
10.1101/2020.01.08.898320 — physiology — Posted on 2021-01-13
2584 RatsPub: a webservice aided by deep learning to mine PubMed for addiction-related genes
Gunturkun, M. H.; Flashner, E.; Wang, T.; Mulligan, M. K.; Williams, R. W.; Prins, P.; Chen, H.
10.1101/2020.09.17.297358 — bioinformatics — Posted on 2021-01-13
2585 Climate predicts geographic and temporal variation in mosquito-borne disease dynamics on two continents
Caldwell, J. M.; LaBeaud, A. D.; Lambin, E. F.; Stewart-Ibarra, A. M.; Ndenga, B. A.; Mutuku, F. M.; Krystosik, A. R.; Ayala, E. B.; Anyamba, A.; Borbor-Cordova, M. J.; Damoah, R.; Grossi-Soyster, E. N.; Heras Heras, F.; Ngugi, H. N.; Ryan, S. J.; Shah, M. M.; Sippy, R.; Mordecai, E. A.
10.1101/2020.02.07.938720 — ecology — Posted on 2021-01-13
2587 Meaningful Effects in the Adolescent Brain Cognitive Development Study
Dick, A. S.; Lopez, D. A.; Watts, A. L.; Heeringa, S. G.; Reuter, C.; Bartsch, H.; Fan, C. C.; Kennedy, D.; Palmer, C. E.; Marshall, A. T.; Haist, F.; Hawes, S.; Nichols, T.; Barch, D. M.; Jernigan, T. L.; Garavan, H.; Grant, S.; Pariyadath, V.; Hoffman, E.; Neale, M.; Stuart, E.; Paulus, M. P.; Sher, K.; Thompson, W.
10.1101/2020.09.01.276451 — neuroscience — Posted on 2021-01-13
2589 Mutational impact and signature of ionizing radiation
Youk, J.; Kwon, H. W.; Lim, J.; Kim, E.; Kim, R.; Park, S.; Yi, K.; Jeon, S.; Choi, J.; Na, H.; Lee, E.-S.; Cho, Y.-W.; Min, D.-W.; Kim, H.; Kang, Y.-R.; Choi, S. H.; Bae, M. J.; Lee, C. G.; Kim, J.-G.; Kim, Y. S.; Lee, D. S.; Kim, T. Y.; Ku, T.; Kim, S. Y.; Lee, J.-H.; Koo, B.-K.; Lee, H.; Yi, O. V.; Han, E. C.; Chang, J. H.; Kim, K. S.; Son, T. G.; Ju, Y. S.
10.1101/2021.01.12.426324 — genomics — Posted on 2021-01-13
2591 Differential gene expression associated with a floral scent polymorphism in the evening primrose Oenothera harringtonii (Onagraceae)
Bechen, L. L.; Johnson, M. G.; Broadhead, G. T.; Levin, R. A.; Overson, R. P.; Jogesh, T.; Fant, J. B.; Raguso, R. A.; Skogen, K. A.; Wickett, N. J.
10.1101/2021.01.12.426409 — evolutionary biology — Posted on 2021-01-13
2592 Periplasm homeostatic regulation maintains spatial constraints essential for cell envelope processes and cell viability
Mandela, E.; Stubenrauch, C. J.; Ryoo, D.; Hwang, H.; Cohen, E. J.; Torres, V. V. L.; Deo, P.; Webb, C. T.; Huang, C.; Schittenhelm, R. B.; Beeby, M.; C. Gumbart, J.; Lithgow, T.; Hay, I. D.
10.1101/2021.01.13.426498 — cell biology — Posted on 2021-01-13
2593 A role for SHARPIN in platelet linear protein ubiquitination and function
Moore, S. F.; Zhao, X.; Mallah, S.; Poole, A. W.; Mundell, S. J.; Hutchinson, J. L.; Hers, I.
10.1101/2021.01.13.426403 — cell biology — Posted on 2021-01-13
2594 New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure
Li, H.; Wang, S.; Lee, F.-H.; Roark, R. S.; Murphy, A. I.; Smith, J.; Zhao, C.; Rando, J.; Chohan, N.; Ding, Y.; Kim, E.; Lindemuth, E.; Bar, K. J.; Pandrea, I.; Apetrei, C.; Keele, B. F.; Lifson, J. D.; Lewis, M. G.; Denny, T. N.; Haynes, B. F.; Hahn, B. H.; Shaw, G. M.
10.1101/2021.01.13.426578 — microbiology — Posted on 2021-01-13
2596 Apolipoprotein M attenuates doxorubicin cardiotoxicity by regulating transcription factor EB
Guo, Z.; Picataggi, A.; Ripoll, C. V.; Chendamarai, E.; Girardi, A.; Riehl, T.; Evie, H.; Torrecilla, J. V.; Kovacs, A.; Hyrc, K.; Ma, X.; Asnani, A.; Shewale, S. V.; Scherrer-Crosbie, M.; Cowart, L. A.; Parks, J. S.; Diwan, A.; Margulies, K. B.; Christoffersen, C.; Rettig, M. P.; DiPersio, J. F.; Javaheri, A.
10.1101/2021.01.12.426397 — pharmacology and toxicology — Posted on 2021-01-13
2598 Insights into G-Quadruplex-Hemin Dynamics Using Atomistic Simulations: Implications for Reactivity and Folding
Stadlbauer, P.; Islam, B.; Otyepka, M.; Chen, J.; Monchaud, D.; Zhou, J.; Mergny, J.-L.; Sponer, J.
10.1101/2020.11.09.375691 — biophysics — Posted on 2021-01-13
2599 Biomaterials direct functional B cell response in a material specific manner
Moore, E.; Maestas, D. R.; Cherry, C. C.; Garcia, J. A.; Comeau, H. Y.; Davenport Huyer, L.; Blosser, R. L.; Rosson, G. D.; Elisseeff, J. H.
10.1101/2021.01.12.426347 — bioengineering — Posted on 2021-01-13
2609 PIWI silencing mechanism involving the retrotransposon nimbus orchestrates resistance to infection with Schistosoma mansoni in the snail vector, Biomphalaria glabrata
Knight, M.; Smith, M.; Yadav, S.; Akinyele, O. G.; Pels, N. A.; Horton, D.; Alsultan, N.; Borns, A.; Cousin, C.; Dixon, F.; Mann, V. H.; Lee, C.; Brindley, P. J.; El-Sayed, N. M.; Bridger, J. M.; Knight, M. R.
10.1101/2021.01.12.426235 — molecular biology — Posted on 2021-01-13
2610 Listeria monocytogenes faecal carriage is common and driven by microbiota
Garcia-Garcera, M.; Hafner, L.; Burucoa, C.; Moura, A.; Pichon, M.; Lecuit, M.
10.1101/2021.01.13.426560 — microbiology — Posted on 2021-01-13
2611 Targeting conserved viral virulence determinants by single domain antibodies to block SARS-CoV2 infectivity
Singh, S.; Dahiya, S.; Singh, Y. J.; Beeton, K.; Jain, A.; Sarkar, R.; Dubey, A.; Tehseen, S. A.; Sehrawat, S.
10.1101/2021.01.13.426537 — immunology — Posted on 2021-01-13
2615 Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans
Kanen, J. W.; Luo, Q.; Kandroodi, M. R.; Cardinal, R. N.; Robbins, T. W.; Carhart-Harris, R. L.; den Ouden, H. E.
10.1101/2020.12.04.412189 — neuroscience — Posted on 2021-01-13
2618 BRN2 is a non-canonical melanoma tumor-suppressor
Hamm, M.; Sohier, P.; Petit, V.; Raymond, J.; Delmas, V.; Le Coz, M.; Gesbert, F.; Kenny, C.; Aktary, Z.; Pouteaux, M.; Rambow, F.; Sarasin, A.; Bellacosa, A.; Sanchez-del-Campo, L.; Mosteo, L.; Lauss, M.; Meijer, D.; Steingrimsson, E.; Jonsson, G.; Cornell, R.; Davidson, I.; Goding, C.; Larue, L.
10.1101/2021.01.13.426554 — cancer biology — Posted on 2021-01-13
2620 Diet induced hyperlipidemia confers resistance to standard therapy in pancreatic cancer by selecting for "tumor protective" microbial metabolites and treatment refractory cells.
Kesh, K.; Mendez, R.; Mateo-Victoriano, B.; Garrido, V. T.; Durden, B.; Gupta, V. K.; Reyes, A. O.; Datta, J.; Merchant, N.; Banerjee, S.; Banerjee, S.
10.1101/2021.01.12.426380 — cancer biology — Posted on 2021-01-13
2621 Raman spectroscopy on microcalcifications reveals peculiar differences between male and female breast cancer
Caldarone, A.; Piccotti, F.; Morasso, C.; Truffi, M.; Sottotetti, F.; Guerra, C.; Albasini, S.; Agozzino, M.; Villani, L.; Corsi, F.
10.1101/2021.01.12.426331 — cancer biology — Posted on 2021-01-13
2623 Phylogenomics of plant-associated Botryosphaeriaceae species
Garcia, J.; Laurence, D. P.; Morales-Cruz, A.; Travadon, R.; Minio, A.; Hernadez-Martinez, R.; Rolshausen, P. E.; Baumgartner, K.; Cantu, D.
10.1101/2021.01.12.426103 — genomics — Posted on 2021-01-13
2630 Dynlt3, a novel fundamental regulator of melanosome movement, distribution, maturation and transfer
Aktary, Z.; Conde, A.; Rambow, F.; Di Marco, M.; Amblard, F.; Hurbain, I.; Raposo, G.; Delevoye, C.; Coscoy, S.; LARUE, L.
10.1101/2021.01.13.426541 — cell biology — Posted on 2021-01-13
2631 Large-scale Genetic Characterization of a Model Sulfate Reducing Bacterium
Trotter, V. V.; Shatsky, M.; Price, M. N.; Juba, T. R.; Zane, G. M.; De Leon, K. P.; Majumder, E. L.; Gui, Q.; Ali, R.; Wetmore, K. M.; Kuehl, J. V.; Arkin, A. P.; Wall, J. D.; Deutschbauer, A. M.; Chandonia, J.-M.; Butland, G. P.
10.1101/2021.01.13.426591 — microbiology — Posted on 2021-01-13
2632 Mucoricin is a Ricin-Like Toxin that is Critical for the Pathogenesis of Mucormycosis
Soliman, S.; Baldin, C.; Gu, Y.; Singh, S.; Gebremariam, T.; Swidergall, M.; Alqarihi, A.; Youssef, E.; Alkhazraji, S.; Pikoulas, A.; Perske, C.; Venkataramani, V.; Rich, A.; Bruno, V. M.; Dunning Hotopp, J. C.; Mantis, N. J.; Edwards, J.; Filler, S.; Chamilos, G.; Vitetta, E. S.; Ibrahim, A. S.
10.1101/2021.01.13.426274 — microbiology — Posted on 2021-01-13
2633 Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice
Haigh, J. L.; Adhikari, A.; Copping, N. A.; Stradleigh, T. W.; Wade, A. A.; Catta-Preta, R. F.; Su-Feher, L.; Zdilar, I.; Morse, S. J.; Fenton, T. A.; Nguyen, A. B.; Quintero, D. M.; Agezew, S.; Sramek, M.; Carter, J. L.; Gompers, A.; Lambert, J. T.; Canales, C. P.; Pennacchio, L.; Visel, A.; Dickel, D.; Silverman, J. L.; Nord, A. S.
10.1101/766634 — neuroscience — Posted on 2021-01-13
2634 Temporal uncertainty enhances suppression of neural responses to predictable visual stimuli
Nara, S.; Lizarazu, M.; Richter, C. G.; Dima, D. C.; Cichy, R. M.; Bourguignon, M.; Molinaro, N.
10.1101/2020.08.26.265884 — neuroscience — Posted on 2021-01-13
2635 Identification of a Pathway for Electron Uptake in Shewanella oneidensis
Rowe, A.; Salimijazi, F.; Trutschel, L.; Sackett, J.; Adesina, O.; Anzai, I.; Kugelmass, L. H.; Baym, M.; Barstow, B.
10.1101/2021.01.12.426419 — systems biology — Posted on 2021-01-13
2636 ARID1A-mutant and deficient bladder cancer is sensitive to EZH2 pharmacologic inhibition
Ferguson, J. E.; Rehman, H.; Chandrashekar, D. S.; Chakravarthi, B.; Nepal, S.; Eich, M.-L.; Robinson, A.; Agarwal, S.; Balasubramanya, S. A. H.; Naik, G.; Manne, U.; Netto, G.; Pan, C.-x.; Sonpavde, G.; Varambally, S.
10.1101/2021.01.12.426383 — cancer biology — Posted on 2021-01-13
2637 Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice
Kay, J. E.; Corrigan, J. J.; Armijo, A. L.; Nazari, I. S.; Kohale, I. N.; Torous, D. K.; Avlasevich, S. L.; Croy, R. G.; Wadduwage, D. N.; Carrasco, S. E.; Dertinger, S. D.; White, F. M.; Essigmann, J. M.; Samson, L. D.; Engelward, B. P.
10.1101/2021.01.12.426356 — cancer biology — Posted on 2021-01-13
2639 Rigid monoclonal antibodies improve detection of SARS-CoV-2 nucleocapsid protein
Hodge, C. D.; Rosenberg, D. J.; Wilamowski, M.; Joachimiak, A. D.; Hura, G. L.; Hammel, M.
10.1101/2021.01.13.426597 — biophysics — Posted on 2021-01-13
2643 Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1
Li, S.; Li, Y.; Rushing, B. R.; McRitchie, S. L.; Jones, J. C.; Sumner, S. J.; Dohlman, H. G.
10.1101/2021.01.12.426444 — genomics — Posted on 2021-01-13
2644 DsbA-L protects against diabetic renal injury through the adipo-renal axis
Lin, P. H.; Zeng, F. L.; Yang, M.; Hu, C.; Zhao, L.; Chen, H. X.; Wei, P. Y.
10.1101/2021.01.12.426410 — genetics — Posted on 2021-01-13
2645 Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling
Ariosa-Morejon, Y.; Santos, A.; Fisher, R.; Davis, S.; Charles, P.; Thakker, R. V.; Wann, A.; Vincent, T. L.
10.1101/2021.01.13.426496 — developmental biology — Posted on 2021-01-13
2647 Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals a Broad Potential Host Range of SARS-CoV-2
Liu, Y.; Hu, G.; Wang, Y.; Zhao, X.; Ji, F.; Ren, W.; Gong, M.; Ju, X.; Zhu, Y.; Cai, X.; Wu, J.; Lan, X.; Xie, Y.; Wang, X.; Yuan, Z.; Zhang, R.; Ding, Q.
10.1101/2020.04.22.046565 — microbiology — Posted on 2021-01-13
2648 Immune responses in pancreatic cancer may be restricted byprevalence of activated regulatory T-cells, dysfunctionalCD8+ T-cells, and senescent T-cells
Sivakumar, S.; Abu-Shah, E.; Ahern, D.; Arbe-Barnes, E. H.; Mangal, N.; Reddy, S.; Rendek, A.; Easton, A.; Kurz, E.; Silva, M.; Heij, L. R.; Soonawalla, Z.; Bashford-Rogers, R.; Middleton, M. R.; Dustin, M.
10.1101/2020.06.20.163071 — immunology — Posted on 2021-01-13
2650 Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression
Carossino, M.; Montanaro, P.; O'Connell, A.; Kenney, D.; Gertje, H.; Grosz, K.; Kurnick, S.; Bosmann, M.; Saeed, M.; Balasuriya, U.; Douam, F.; Crossland, N.
10.1101/2021.01.13.425144 — pathology — Posted on 2021-01-13
2652 Robust RNA editing via recruitment of endogenous ADARs using circular guide RNAs
Katrekar, D.; Yen, J.; Xiang, Y.; Saha, A.; Meluzzi, D.; Savva, Y.; Mali, P.
10.1101/2021.01.12.426286 — bioengineering — Posted on 2021-01-13
2653 High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy
Streich, L.; Boffi, J. C.; Wang, L.; Alhalaseh, K.; Barbieri, M.; Rehm, R.; Deivasigamani, S.; Gross, C.; Agarwal, A.; Prevedel, R.
10.1101/2021.01.12.426323 — bioengineering — Posted on 2021-01-13
2654 Emergence and Evolution of a Prevalent New SARS-CoV-2 Variant in the United States
Pater, A. A.; Bosmeny, M. S.; Barkau, C. L.; Ovington, K. N.; Chilamkurthy, R.; Parasrampuria, M.; Eddington, S. B.; Yinusa, A. O.; White, A. A.; Metz, P. E.; Sylvain, R. J.; Hebert, M. M.; Benzinger, S. W.; Sinha, K. T.; Gagnon, K. T.
10.1101/2021.01.11.426287 — genomics — Posted on 2021-01-13
2656 Distinct lung-homing receptor expression and activation profiles on NK cell and T cell subsets in COVID-19 and influenza
Brownlie, D.; Rodahl, I.; Varnaite, R.; Asgeirsson, H.; Glans, H.; Falck-Jones, S.; Vangeti, S.; Buggert, M.; Ljunggren, H.-G.; Michaëlsson, J.; Gredmark-Russ, S.; Smed-Sörensen, A.; Marquardt, N.
10.1101/2021.01.13.426553 — immunology — Posted on 2021-01-13
2660 Rapid screening of pest resistance genes in maize using a sugarcane mosaic virus vector
Chung, S. H.; Bigham, M.; Lappe, R. R.; Chan, B.; Nagalakshmi, U.; Whitham, S. A.; Dinesh-Kumar, S. P.; Jander, G.
10.1101/2021.01.13.425472 — plant biology — Posted on 2021-01-13
2661 Proline-rich Extensin-like Receptor Kinases PERK5 and PERK12 are involved in Pollen Tube Growth
Borassi, C.; Sede, A.; Mecchia, M. A.; Mangano, S.; Marzol, E.; Denita-Juarez, S. P.; Salgado Salter, J. D.; Velasquez, S. M.; Muschietti, J. P.; Estevez, J.
10.1101/2021.01.12.425807 — plant biology — Posted on 2021-01-13
2663 A simple explanation for declining temperature sensitivity with warming
Wolkovich, E. M.; Auerbach, J. L.; Chamberlain, C. J.; Buonaiuto, D. M.; Ettinger, A. K.; Morales-Castilla, I.; Gelman, A.
10.1101/2021.01.12.426288 — plant biology — Posted on 2021-01-13
2667 Niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica
Knodler, L. A.; Powers, T. R.; Haeberle, A. L.; Hammarlöf, D. L.; Cundiff, J. A.; Predeus, A. V.; Hokamp, K.; Hinton, J. C. D.
10.1101/2021.01.11.426201 — microbiology — Posted on 2021-01-13
2669 The SLIM1 transcription factor regulates arsenic sensitivity in Arabidopsis thaliana
Jobe, T. O.; Yu, Q.; Hauser, F.; Xie, Q.; Meng, Y.; Maassen, T.; Kopriva, S.; Schroeder, J.
10.1101/2021.01.12.426316 — plant biology — Posted on 2021-01-13
2671 A rapid phenomics workflow for the in vitro identification of antiviral drugs
Rietdijk, J.; Tempere, M.; Pettke, A.; Georgiev, P.; Lapins, M.; Warpman Berglund, U.; Spjuth, O.; Puumalainen, M.-R.; Carreras-Puigvert, J.
10.1101/2021.01.13.423947 — pharmacology and toxicology — Posted on 2021-01-13
2672 Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identity
Thirant, C.; Peltier, A.; Durand, S.; Kramdi, A.; Louis-Brennetot, C.; Pierre-Eugene, C.; Costa, A.; Grelier, A.; Zaidi, S.; Gruel, N.; Jimenez, I.; Lapouble, E.; Pierron, G.; Brisse, H.; Gauthier, A.; Freneaux, P.; Grossetete-Lalami, S.; Baudrin, L. G.; Raynal, V.; Baulande, S.; Bellini, A.; Bhalshankar, J.; Carcaboso, A. M.; Geoerger, B.; Surdez, D.; Rohrer, H.; Boeva, V.; Schleiermacher, G.; Delattre, O.; Janoueix-Lerosey, I.
10.1101/2021.01.07.425710 — cancer biology — Posted on 2021-01-13
2674 Optical measurement of voltage sensing by endogenous ion channel
Thapa, P.; Stewart, R.; Sepela, R. J.; Vivas, O.; Parajuli, L. K.; Lillya, M.; Fletcher-Taylor, S.; Cohen, B. E.; Zito, K.; Sack, J. T.
10.1101/541805 — biophysics — Posted on 2021-01-13
2677 Visualizing protein-protein interactions in plants by rapamycin-dependent delocalization
Winkler, J.; Mylle, E.; De Meyer, A.; Pavie, B.; Merchie, J.; Grones, P.; Van Damme, D.
10.1101/2020.03.09.983270 — cell biology — Posted on 2021-01-13
2678 Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable
Viana, M. P.; Chen, J.; Knijnenburg, T. A.; Vasan, R.; Yan, C.; Arakaki, J. E.; Bailey, M.; Berry, B.; Borensztejn, A.; Brown, J. M.; Carlson, S.; Cass, J. A.; Chaudhuri, B.; Cordes Metzler, K. R.; Coston, M. E.; Crabtree, Z. J.; Davidson, S.; DeLizo, C. M.; Dhaka, S.; Dinh, S. Q.; Do, T. P.; Domingus, J.; Donovan-Maiye, R. M.; Foster, T. J.; Frick, C. L.; Fujioka, G.; Fuqua, M. A.; Gehring, J. L.; Gerbin, K. A.; Grancharova, T.; Gregor, B. W.; Harrylock, L. J.; Haupt, A.; Hendershott, M. C.; Hookway, C.; Horwitz, A. R.; Hughes, C.; Isaac, E. J.; Johnson, G. R.; Kim, B.; Leonard, A. N.; Leung,
10.1101/2020.12.08.415562 — cell biology — Posted on 2021-01-13
2679 GSDMD Deficiency Protects Against Aortic Rupture
Ye, D.; Howatt, D.; Li, Z.; Daugherty, A.; Lu, H. S.; Wu, C.
10.1101/2021.01.08.425983 — molecular biology — Posted on 2021-01-13
2682 Trait-based responses to forestry and reindeer husbandry modify long-term changes in forest understories
Happonen, K.; Muurinen, L.; Virtanen, R.; Kaakinen, E.; Grytnes, J.-A.; Kaarlejärvi, E.; Parisot, P.; Wolff, M.; Maliniemi, T.
10.1101/2020.04.30.069708 — ecology — Posted on 2021-01-13
2684 The Necroptosis Effector MLKL drives Small Extracellular Vesicle Release and Tumour Growth in Glioblastoma
Andre-Gregoire, G.; Douanne, T.; Thys, A.; Maghe, C.; Jacobs, K. A.; Ballu, C.; Trillet, K.; Busnelli, I.; Hyenne, V.; Bidere, N.; Gavard, J.
10.1101/2021.01.12.426398 — cell biology — Posted on 2021-01-13
2685 Molecular architecture of the endocytic TPLATE complex
Yperman, K.; Wang, J.; Eeckhout, D.; Winkler, J.; Vu, L.; Vandorpe, M.; Grones, P.; Mylle, E.; Kraus, M.; Merceron, R.; Nolf, J.; Mor, E.; De Bruyn, P.; Loris, R.; Potocky, M.; Savvides, S. N.; De Rybel, B.; De Jaeger, G.; Van Damme, D.; Pleskot, R.
10.1101/2020.08.13.249276 — cell biology — Posted on 2021-01-13
2686 Achromobacter genetic adaptation in cystic fibrosis
Gabrielaite, M.; Johansen, H. K.; Nielsen, F. C.; Marvig, R. L.
10.1101/2021.01.13.426490 — microbiology — Posted on 2021-01-13
2689 DNA looping by protamine follows a nonuniform spatialdistribution
McMillan, R. B.; Kuntz, V. D.; Devenica, L. M.; Bediako, H.; Carter, A. R.
10.1101/2021.01.12.426418 — biophysics — Posted on 2021-01-13
2691 Structure and dynamics of semaglutide and taspoglutide bound GLP-1R-Gs complexes
Zhang, X.; Belousoff, M. J.; Liang, Y.-L.; Danev, R.; Sexton, P. M.; Wootten, D.
10.1101/2021.01.12.426449 — biochemistry — Posted on 2021-01-13
2692 The genetic architecture of human cortical folding
van der Meer, D.; Kaufmann, T.; Shadrin, A. A.; Makowski, C.; Frei, O.; Roelfs, D.; Monereo Sanchez, J.; Linden, D. E.; Rokicki, J.; de Leeuw, C.; Thompson, W. K.; Loughnan, R. J.; Fan, C. C.; Thompson, P. M.; Westlye, L. T.; Andreassen, O. A.; Dale, A. M.
10.1101/2021.01.13.426555 — genomics — Posted on 2021-01-13
2693 Novel CHD8 genomic targets identified in fetal mouse brain by in vivo Targeted DamID
Wade, A. A.; van den Ameele, J.; Cheetham, S. W.; Yakob, R.; Brand, A. H.; Nord, A. S.
10.1101/2021.01.12.426468 — genomics — Posted on 2021-01-13
2694 Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants
Damotte, V.; van der Lee, S. J.; Chouraki, V.; Grenier-Boley, B.; Simino, J.; Adams, H.; Tosto, G.; White, C.; Terzikhan, N.; Cruchaga, C.; Knol, M. J.; Li, S.; Schraen, S.; Grove, M. L.; Satizabal, C. L.; Amin, N.; Berr, C.; Younkin, S.; Alzheimer's Disease Neuroimaging Initiative, ; Gottesman, R. F.; Buee, L.; Beiser, A.; Knopman, D. S.; Uitterlinden, A.; DeCarli, C.; Bressler, J.; DeStefano, A.; Dartigues, J.-F.; Yang, Q.; Boerwinkle, E.; Tzourio, C.; Fornage, M.; Ikram, M. A.; Amouyel, P.; de Jager, P.; Reitz, C.; Mosley, T. H.; Lambert, J.-C.; Seshadri, S.; van Duijn, C.
10.1101/194266 — genetics — Posted on 2021-01-13
2695 Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution
Griesemer, D.; Xue, J. R.; Reilly, S. K.; Ulirsch, J. C.; Kukreja, K.; Davis, J.; Kanai, M.; Yang, D. K.; Montgomery, S. B.; Novina, C. D.; Tewhey, R.; Sabeti, P. C.
10.1101/2021.01.13.424697 — genetics — Posted on 2021-01-13
2698 Reducing phenotypic and genotypic instabilities of microbial population during continuous cultivation based on stochastic switching dynamics
Nguyen, T. M.; Telek, S.; Zicler, A.; Martinez, J. A.; Zacchetti, B.; Kopp, J.; Slouka, C.; Herwig, C.; Gruenberger, A.; Frank, D.
10.1101/2021.01.13.426484 — microbiology — Posted on 2021-01-13
2699 Decoding shared versus divergent transcriptomic signatures across cortico-amygdala circuitry in PTSD and depressive disorders
Jaffe, A. E.; Barry, B. K.; Tao, R.; Tran, M. N.; Page, S. C.; Maynard, K. R.; Pattie, E. A.; Nguyen, C. V.; Deep-Soboslay, A.; Bharadwaj, R.; Young, K. A.; Friedman, M. J.; Williamson, D. E.; Traumatic Stress Brain Research Group, ; Shin, J. H.; Hyde, T. M.; Martinowich, K.; Kleinman, J. E.
10.1101/2021.01.12.426438 — neuroscience — Posted on 2021-01-13
2700 A bacterial GW-effector directly targets Arabidopsis Argonaute 1 to suppress PAMP-triggered immunity and cause disease
Thiebeauld, O.; Charvin, M.; Singla Rastogi, M.; Yang, F.; Pontier, D.; Pouzet, C.; Bapaume, L.; Amsefe, D.; Li, G.; Deslandes, L.; Lagrange, T.; Alfano, J. R.; Navarro, L.
10.1101/215590 — plant biology — Posted on 2021-01-13
2703 Single cell label-free probing of chromatin dynamics during B lymphocyte maturation
Morrish, R.; Yim, K. H. W.; Pagliara, S.; Palombo, F.; Chahwan, R.; Stone, N.
10.1101/2021.01.12.426344 — biophysics — Posted on 2021-01-13
2705 Individual Molecular Motors use Low Forces to bypass Roadblocks during Collective Cargo Transport
Shukla, S.; Troitskaia, A.; Swarna, N.; Maity, B. K.; Tjioe, M.; Bookwalter, C. S.; Chrin, L.; Berger, C. L.; Trybus, K. M.; Chemla, Y. R.; Selvin, P. R.
10.1101/2021.01.12.425491 — biophysics — Posted on 2021-01-13
2708 Community RNA-Seq: Multi-kingdom responses to living versus decaying root inputs in soil
Nuccio, E. E.; Nguyen, N. H.; Nunes da Rocha, U.; Mayali, X.; Bougoure, J.; Weber, P.; Brodie, E. L.; Firestone, M. K.; Pett-Ridge, J.
10.1101/2021.01.12.426429 — microbiology — Posted on 2021-01-13
2709 A conserved uORF impacts APOBEC3G translation and is essential for translational inhibition by the HIV-1 Vif protein
Libre, C.; Seissler, T.; Guerrero, S.; Batisse, J.; Verriez, C.; Stupfler, B.; Gilmer, O.; Weber, M. M.; Cimarelli, A.; Etienne, L.; Marquet, R.; Paillart, J.-C.
10.1101/2021.01.13.426487 — microbiology — Posted on 2021-01-13
2712 Paradoxes and synergies: optimizing management of a deadly virus in an endangered carnivore
Gilbertson, M. L. J.; Onorato, D.; Cunningham, M. W.; VandeWoude, S.; Craft, M. E.
10.1101/2021.01.11.426249 — ecology — Posted on 2021-01-13
2713 Sub-lethal aquatic doses of pyriproxyfen may increase pyrethroid resistance in malaria mosquitoes
Opiyo, M. A.; Ngowo, H. S.; Mapua, S. A.; Mpingwa, M.; Matowo, N. S.; Majambere, S.; Okumu, F. O.
10.1101/2021.01.11.426299 — ecology — Posted on 2021-01-13
2714 Anomalous brain energy in old age by wavelet analysis of ERP during a Stroop task
Sanchez Moguel, S. M.; Baravalle, R.; Gonzalez-Salinas, S.; Rosso, O. A.; Fernandez, T.; Montani, F.
10.1101/2021.01.11.426273 — neuroscience — Posted on 2021-01-13
2717 Acquired olfactory loss alters functional connectivity and morphology
Iravani, B.; Peter, M. G.; Arshamian, A.; Olsson, M. J.; Hummel, T.; Kitzler, H. H.; Lundström, J. N.
10.1101/2021.01.11.426175 — neuroscience — Posted on 2021-01-13
2718 The SLIM1 transcription factor regulates arsenic sensitivity in Arabidopsis thaliana
Jobe, T. O.; Yu, Q.; Hauser, F.; Xie, Q.; Meng, Y.; Maassen, T.; Kopriva, S.; Schroeder, J.
10.1101/2021.01.12.426316 — plant biology — Posted on 2021-01-13
2719 Human colorectal pre-cancer atlas identifies distinct molecular programs underlying two major subclasses of pre-malignant tumors
Chen, B.; McKinley, E. T.; Simmons, A. J.; Ramirez, M. A.; Zhu, X.; Southard-Smith, A. N.; Markham, N. O.; Sheng, Q.; Drewes, J.; Xu, Y.; Heiser, C. N.; Zhou, Y.; Revetta, F.; Berry, L. D.; Zheng, W.; Washington, M. K.; Cai, Q.; Sears, C. L.; Goldenring, J. R.; Franklin, J. L.; Vandekar, S.; Roland, J. T.; Su, T.; Huh, W. J.; Liu, Q.; Coffey, R. J.; Shrubsole, M. J.; Lau, K.
10.1101/2021.01.11.426044 — cancer biology — Posted on 2021-01-13
2722 A heritable androgenic mechanism of female intrasexual competition in cooperatively breeding meerkats
Drea, C. M.; Davies, C. S.; Greene, L. K.; Mitchell, J.; Blondel, D. V.; Shearer, C. L.; Feldblum, J. T.; Dimac-Stohl, K. A.; Smyth-Kabay, K. N.; Clutton-Brock, T. H.
10.1101/2021.01.11.425748 — animal behavior and cognition — Posted on 2021-01-13
2723 An insight into neurotoxic and toxicity of spike fragments SARS-CoV-2 by exposure environment: A threat to aquatic health?
Charlie-Silva, I.; Araujo, A.; Guimaraes, A.; Veras, F.; Braz, H.; Pontes, L.; Jorge, R.; Belo, M.; Fernandes, B.; Nobrega, R. H.; Galdino, G.; Condino-Neto, A.; Galindo-Villegas, J.; Machodo-Santelli, G.; Sanches, P.; Rezende, R.; Cilli, E.; Malafaia, G.
10.1101/2021.01.11.425914 — molecular biology — Posted on 2021-01-13
2725 Cell-to-cell heterogeneity in Sox2 and Brachyury expression ratios guides progenitor destiny by controlling their motility.
Romanos, M.; Allio, G.; Combres, L.; Medevielle, F.; Escalas, N.; Soula, C.; Steventon, B.; Trescases, A.; Benazeraf, B.
10.1101/2020.11.18.388611 — developmental biology — Posted on 2021-01-13
2729 A small increase in CHEK1 activity leads to the arrest of the first zygotic division in human
Chen, B.; Guo, J.; Wang, T.; Lee, Q.; Ming, J.; Ding, F.; Li, H.; Zhang, Z.; Li, L.; Cao, Y.; Na, J.
10.1101/2020.12.26.424381 — developmental biology — Posted on 2021-01-13
2734 A persistent giant algal virus, with a unique morphology, encodes an unprecedented number of genes involved in energy metabolism
Blanc-Mathieu, R.; Dahle, H.; Hofgaard, A.; Brandt, D.; Ban, H.; Kalinowski, J.; Ogata, H.; Sandaa, R.-A.
10.1101/2020.07.30.228163 — microbiology — Posted on 2021-01-13
2740 Identification of Fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration
Ambati, M.; Apicella, I.; Narendran, S.; Wang, S.-b.; Leung, H.; Pereira, F.; Varshney, A.; Shadmehr, M.; Stains, C.; Werner, B.; Baker, K.; Marion, K.; Sadda, S.; Taylor, E.; Magagnoli, J.; Sutton, S. S.; Gelfand, B.
10.1101/2021.01.11.425135 — immunology — Posted on 2021-01-13
2742 Multimodal Learning of Pheromone Locations
Pardasani, M.; Marathe, S. D.; Purnapatre, M. M.; Dalvi, U.; Abraham, N. M.
10.1101/2019.12.22.886564 — neuroscience — Posted on 2021-01-13
2745 The duration of antibiotic treatment is associated with carriage of toxigenic and atoxigenic strains of Clostridioides difficile in dogs.
Albuquerque, C.; Pagnossin, D.; Landsgaard, K.; Simpson, J.; Brown, D.; Irvine, J.; Candlish, D.; Ridyard, A.; Douce, G.; Millins, C.
10.1101/2021.01.12.426335 — microbiology — Posted on 2021-01-12
2746 MR relaxometry-based analysis of brain hemorrhages: an experimental study on a rabbit model
DEL SIGNORE, F.; Vignoli, M.; Della Salda, L.; Tamburro, R.; Cerasoli, I.; Paolini, A.; Romanucci, M.; de Pasquale, F.
10.1101/2021.01.12.426333 — neuroscience — Posted on 2021-01-12
2747 Reduced axon caliber in the associative striatum of the Sapap3 knockout mouse
Lousada, E.; Boudreau, M.; Cohen-Adad, J.; Nait Oumesmar, B.; Burguiere, E.; Schreiweis, C.
10.1101/2021.01.12.426339 — neuroscience — Posted on 2021-01-12
2749 NMDARs expressed in Granule Cells are involved in cerebellar plasticity and motor learning
Schonewille, M.; Girasole, A. E.; Rostaing, P.; Mailhes-Hamon, C.; Nelson, A. B.; Triller, A.; Casado, M.; De Zeeuw, C. I.; Bouvier, G.
10.1101/2021.01.12.426386 — neuroscience — Posted on 2021-01-12
2750 Nucleus accumbens neurons encode initiation and vigor of reward approach behavior
Levcik, D.; Sugi, A. H.; Pochapski, J. A.; Baltazar, G.; Pulido, L. N.; Villas-Boas, C.; Aguilar-Rivera, M.; Fuentes-Flores, R.; Nicola, S. M.; Da Cunha, C.
10.1101/2021.01.12.425739 — neuroscience — Posted on 2021-01-12
2752 Cooperative Communication with Humans Evolved to Emerge Early in Dogs
Salomons, H.; Smith, K.; Callahan-Beckel, M.; Callahan, M.; Levy, K.; Kennedy, B. S.; Bray, E.; Gnanadesikan, G. E.; Horschler, D. J.; Gruen, M.; Tan, J.; White, P.; MacLean, E.; Hare, B.
10.1101/2021.01.12.425620 — animal behavior and cognition — Posted on 2021-01-12
2756 Identification of Fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration
Gelfand, B.; Ambati, M.; Apicella, I.; Narendran, S.; Wang, S.-b.; Leung, H.; Pereira, F.; Varshney, A.; Shadmehr, M.; Stains, C.; Werner, B.; Baker, K.; Marion, K.; Sadda, S.; Taylor, E.; Magagnoli, J.; Sutton, S. S.
10.1101/2021.01.11.425135 — immunology — Posted on 2021-01-12
2757 The Th1 cell regulatory circuitry is largely conserved between human and mouse
Henderson, S.; Pullabhatla, V.; Hertweck, A.; de Rinaldis, E.; Herrero, J.; Lord, G. M.; Jenner, R. G.
10.1101/2021.01.11.426266 — immunology — Posted on 2021-01-12
2758 Developmental effects on pattern visual evoked potentials characterized by principal component analysis
Patterson Gentile, C.; Joshi, N. R.; Ciuffreda, K.; Arbogast, K.; Master, C.; Aguirre, G.
10.1101/2020.12.11.420158 — neuroscience — Posted on 2021-01-12
2762 Natural variation in GmRAV confers ecological adaptation through photoperiod control of flowering time and maturity in soybean
Zhao, L.; Wang, Y.; Xu, C.; Sun, J.; Dong, L.; Li, M.; Liu, Y.; Wang, J.; Zhang, X.; Li, D.; Sun, J.; Zhang, Y.; Shan, J.; Li, W.
10.1101/2021.01.11.426255 — plant biology — Posted on 2021-01-12
2763 Host preference and invasiveness of commensals in the Lotus and Arabidopsis root microbiota
Wippel, K.; Tao, K.; Niu, Y.; Zgadzaj, R.; Guan, R.; Dahms, E.; Zhang, P.; Jensen, D. B.; Logemann, E.; Radutoiu, S.; Schulze-Lefert, P.; Garrido-Oter, R.
10.1101/2021.01.12.426357 — plant biology — Posted on 2021-01-12
2765 OPA1 Deletion in Brown Adipose Tissue Improves Thermoregulation and Systemic Metabolism via FGF21
Pereira, R. O.; Marti, A.; Olvera, A. C.; Tadinada, S. M.; Bjorkman, S. H.; Weatherford, E. T.; Westphal, M.; Patel, P. H.; Kirby, A. K.; Hewezi, R.; Bui Tran, W.; Pena, L. M. G.; Souvenir, R. A.; Mital, M.; Adams, C. M.; Potthoff, M. J.; Abel, E. D.
10.1101/2021.01.04.425181 — physiology — Posted on 2021-01-12
2766 Inhibitor Binding Modulates Protonation States in the Active Site of SARS-CoV-2 Main Protease
Kneller, D. W.; Phillips, G.; Weiss, K. L.; Zhang, Q.; Coates, L.; Kovalevsky, A.
10.1101/2021.01.12.426388 — biophysics — Posted on 2021-01-12
2767 Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis
Lucilla, P.; Lasser, M.; Yusuff, T.; Jensen, M.; Ingraham, P.; Huber, E.; Singh, M. D.; Monahan, C.; Iyer, J.; Desai, I.; Karthikeyan, S.; Gould, D. J.; Yennawar, S.; Weiner, A. T.; Pouraja, V. K.; Krishnan, A.; Rolls, M.; Lowery, L. A.; Girirajan, S.
10.1101/2020.09.14.295923 — genomics — Posted on 2021-01-12
2768 High-content single-cell combinatorial indexing
Mulqueen, R. M.; Pokholok, D.; O'Connell, B. L.; Thornton, C. A.; Zhang, F.; O'Roak, B. J.; Link, J.; Yardimci, G. G.; Sears, R. C.; Steemers, F. J.; Adey, A. C.
10.1101/2021.01.11.425995 — genetics — Posted on 2021-01-12
2772 Deficiency of gluconeogenic enzyme PCK1 promotes non-alcoholic steatohepatitis progression by activation of PI3K/AKT/PDGF axis
Ye, Q.; Liu, Y.; Zhang, G.; Deng, H.; Chen, C.; Pan, X.; Wu, K.; Fan, J.; Pan, Q.; Wang, K.; Huang, A.; Tang, N.
10.1101/2021.01.12.426294 — molecular biology — Posted on 2021-01-12
2773 Allosteric MAPKAPK2 Inhibitors Improve Plaque Stability in Advanced Atherosclerosis
Ozcan, L.; Kasikara, C.; Yurdagul, A.; Kuriakose, G.; Hubbard, B.; Serrano-Wu, M. H.; Tabas, I.
10.1101/2021.01.12.426264 — molecular biology — Posted on 2021-01-12
2774 Screening by deep sequencing reveals mediators of miRNA tailing in C. elegans
Prothro, K. P.; Vieux, K.-F.; Palmer, C.; Veksler-Lublinsky, I. I.; McJunkin, K.
10.1101/2021.01.11.426275 — molecular biology — Posted on 2021-01-12
2776 Novel RT-ddPCR assays for determining the transcriptional profile of SARS-CoV-2
Telwatte, S.; Kumar, N.; Vallejo-Gracia, A.; Kumar, G. R.; Lu, C. M.; Ott, M.; Wong, J. K.; Yukl, S. A.
10.1101/2021.01.12.425991 — microbiology — Posted on 2021-01-12
2777 Identification of Nocardia species using Autof MS 1000 and Bruker MALDI-TOF MS systems: A comparison
Ma, B.; Tian, Y.; Han, Y.; Ban, L.; Yang, J.-w.; Qi, X.; Guo, C.; Wang, B.; Yan, W.; Ma, Q.; Wang, S.; Yuan, Y.; Li, Y.
10.1101/2021.01.11.426310 — microbiology — Posted on 2021-01-12
2780 High-content imaging to phenotype antimicrobial effects on individual bacteria at scale
Sridhar, S.; Forrest, S.; Warne, B.; Maes, M.; Baker, S.; Dougan, G.; Bartholdson Scott, J.
10.1101/2021.01.11.426307 — microbiology — Posted on 2021-01-12
2784 Saccharomyces cerevisiae gene expression during fermentation of Pinot noir wines at industrially relevant scale
Reiter, T.; Montpetit, R.; Byer, S.; Frias, I.; Leon, E.; Viano, R.; Mcloughlin, M.; Halligan, T.; Hernandez, D.; Runnebaum, R.; Montpetit, B.
10.1101/2021.01.11.426308 — microbiology — Posted on 2021-01-12
2789 The three-dimensional landscape of chromatin accessibility in Alzheimer's disease
Bendl, J.; Hauberg, M. E.; Girdhar, K.; Im, E.; Vicari, J. M.; Rahman, S.; Dong, P.; Misir, R.; Kleopoulos, S. P.; Reach, S. M.; Apontes, P.; Zeng, B.; Zhang, W.; Voloudakis, G.; Nixon, R. A.; Haroutunian, V.; Hoffman, G. E.; Fullard, J. F.; Roussos, P.
10.1101/2021.01.11.426303 — neuroscience — Posted on 2021-01-12
2796 Evolving cryo-EM structural approaches for GPCR drug discovery
Zhang, X.; Johnson, R. M.; Drulyte, I.; Yu, L.; Kotecha, A.; Danev, R.; Wootten, D.; Sexton, P. M.; Belousoff, M. J.
10.1101/2021.01.11.426276 — biochemistry — Posted on 2021-01-12
2798 Pheromone binding protein shapes olfactory temporal resolution
Shiota, Y.; Sakurai, T.; Ando, N.; Haupt, S. S.; Mitsuno, H.; Daimon, T.; Kanzaki, R.
10.1101/2021.01.11.426239 — neuroscience — Posted on 2021-01-12
2800 Toward Optimized and Predictive Connectomics at Scale
Moon, J. Y.; Mukherjee, P.; Madduri, R. K.; Markowitz, A. J.; Palacios, E. M.; Manley, G. T.; Bremer, P.-T.
10.1101/2021.01.11.426052 — neuroscience — Posted on 2021-01-12
2802 Maternal Biological Age Assessed in Early Pregnancy is Associated with Gestational Age at Birth
Lancaster, E. E.; Lapato, D. M.; Jackson-Cook, C.; Strauss, J. F.; Roberson-Nay, R.; York, T. P.
10.1101/2021.01.11.425979 — genomics — Posted on 2021-01-12
2809 FcγR responses to soluble immune complexes of varying size: A scalable cell-based reporter system
Chen, H.; Maul-Pavicic, A.; Holzer, M.; Salzer, U.; Chevalier, N.; Voll, R. E.; Hengel, H.; Kolb, P.
10.1101/2020.11.11.378232 — immunology — Posted on 2021-01-12
2810 How robust are cross-population signatures of polygenic adaptation in humans?
Refoyo-Martinez, A.; Liu, S.; Jorgensen, A. M.; Jin, X.; Albrechtsen, A.; Martin, A. R.; Racimo, F.
10.1101/2020.07.13.200030 — genetics — Posted on 2021-01-12
2813 SLO2.1 and NALCN form a functional complex to modulate myometrial cell excitability
Ferreira, J. J.; Amazu, C.; Puga-Molina, L. C.; Ma, X.; England, S. K.; Santi, C. M.
10.1101/2020.07.31.229138 — cell biology — Posted on 2021-01-12
2814 Restore mitophagy is essential to prevent cardiac oxidative stress during hypertrophy
Peugnet, V.; Chwastyniak, M.; Lancel, S.; Bultot, L.; Fourny, N.; Beseme, O.; Loyens, A.; Heyse, W.; Amouyel, P.; Bertrand, L.; Pinet, F.; Dubois-Deruy, E.
10.1101/2021.01.12.426366 — cell biology — Posted on 2021-01-12
2815 The Necroptosis Effector MLKL drives Small Extracellular Vesicle Release and Tumour Growth in Glioblastoma
Andre-Gregoire, G.; Douanne, T.; Maghe, C.; Jacobs, K. A.; Ballu, C.; Trillet, K.; Busnelli, I.; Hyenne, V.; Bidere, N.; Gavard, J.
10.1101/2021.01.12.426398 — cell biology — Posted on 2021-01-12
2818 Quantitative Single-Cell Proteomics as a Tool to Characterize Cellular Hierarchies
Schoof, E. M.; Furtwängler, B.; Üresin, N.; Rapin, N.; Savickas, S.; Gentil, C.; Lechman, E.; auf dem Keller, U.; Dick, J. E.; Porse, B.
10.1101/745679 — systems biology — Posted on 2021-01-12
2819 Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance
Cotter, K. A.; Gallon, J.; Uebersax, N.; Rubin, P.; Meyer, K. D.; Piscuoglio, S.; Jaffrey, S. R.; Rubin, M. A.
10.1101/2021.01.12.426354 — cancer biology — Posted on 2021-01-12
2820 Cryo-EM Structure of the N501Y SARS-CoV-2 Spike Protein in Complex with a Potent Neutralizing Antibody
Zhu, X.; Mannar, D.; Srivastava, S. S.; Berezuk, A.; Demers, J.-P.; Saville, J.; Leopold, K.; Li, W.; Dimitrov, D. S.; Tuttle, K.; Zhou, S.; Chittori, S.; Subramaniam, S.
10.1101/2021.01.11.426269 — biophysics — Posted on 2021-01-12
2822 Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the liver
Hildebrandt, F. F. A.; Andersson, A.; Saarenpaa, S.; Larsson, L.; Van Hul, N.; Kanatani, S.; Masek, J.; Ellis, E.; Barragan, A.; Mollbrink, A.; Andersson, E. R.; Lundeberg, J.; Ankarklev, J.
10.1101/2021.01.11.426100 — genomics — Posted on 2021-01-12
2823 Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases
Korsunsky, I.; Wei, K.; Pohin, M.; Kim, E. Y.; Barone, F.; Kang, J. B.; Friedrich, M.; Turner, J.; Nayar, S.; Fisher, B. A.; Raza, K.; Marshall, J. L.; Croft, A. P.; Sholl, L. M.; Vivero, M.; Rosas, I. O.; Bowman, S. J.; Coles, M.; Frei, A. P.; Lassen, K.; Filer, A.; Powrie, F.; Buckley, C. D.; Brenner, M. B.; Raychaudhuri, S.
10.1101/2021.01.11.426253 — genomics — Posted on 2021-01-12
2826 Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets
Francis, M.; Richardson, B.; McNeil, M.; Rioux, M.; Foley, M.; Ge, A.; Pechous, R.; Kindrachuk, J.; Cameron, C.; Richardson, C.; Lew, J.; Cameron, M.; Gerdts, V.; Falzarano, D.; Kelvin, A. A. A.
10.1101/2021.01.12.426381 — microbiology — Posted on 2021-01-12
2827 The genome of a daddy-long-legs (Opiliones) illuminates the evolution of arachnid appendages and chelicerate genome architecture
Gainett, G.; Gonzalez, V. L.; Ballesteros, J. A.; Setton, E. V. W.; Baker, C. M.; Barolo Gargiulo, L.; Santibanez-Lopez, C. E.; Coddington, J. A.; Sharma, P. P.
10.1101/2021.01.11.426205 — developmental biology — Posted on 2021-01-12
2830 Neural heterogeneity promotes robust learning
Perez-Nieves, N.; Leung, V. C. H.; Dragotti, P. L.; Goodman, D. F. M.
10.1101/2020.12.18.423468 — neuroscience — Posted on 2021-01-12
2833 Differential expression of striatal proteins in a mouse model of DOPA-responsive dystonia reveals shared mechanisms among dystonic disorders
Briscione, M. A.; Dinasarapu, A. R.; Bagchi, P.; Donsante, Y.; Downs, A. M.; Fan, X.; Hoehner, J.; Jinnah, H. A.; Hess, E. J.
10.1101/2021.01.12.426367 — neuroscience — Posted on 2021-01-12
2834 A vacuolar hexose transport is required for xylem development in the inflorescence stem of Arabidopsis.
Aubry, E.; Hoffmann, B.; Vilaine, F.; Gilard, F.; Klemens, P. A. W.; Guerard, F.; Gakiere, B.; Neuhaus, H. E.; Bellini, C.; Dinant, S.; Le Hir, R.
10.1101/2020.12.09.417345 — plant biology — Posted on 2021-01-12
2837 QSM Reconstruction Challenge 2.0: a realistic in silico head phantom for MRI data simulation and evaluation of susceptibility mapping procedures
Marques, J. P.; Meineke, J.; Milovic, C.; Bilgic, B.; Chan, K.-S.; Hedouin, R.; vand der Zwaag, W.; Langkammer, C.; Schweser, F.
10.1101/2020.09.29.316836 — neuroscience — Posted on 2021-01-12
2840 Tracking age differences in neural distinctiveness across representational levels
Kobelt, M.; Sommer, V. R.; Keresztes, A.; Werkle-Bergner, M.; Sander, M. C.
10.1101/2020.07.06.187187 — neuroscience — Posted on 2021-01-12
2841 Mechanisms shaping the synergism of zeaxanthin and PsbS in photoprotective energy dissipation in the photosynthetic apparatus of plants
Gruszecki, W. I.; Welc, R.; Luchowski, R.; Kluczyk, D.; Zubik, M.; Grudzinski, W.; Maksim, M.; Reszczynska, E.; Sowinski, K.; Mazur, R.; Nosalewicz, A.
10.1101/2021.01.10.426135 — biophysics — Posted on 2021-01-12
2842 Analyses of cephalic and non-cephalic sensory cell types provide insight into joint photo- and mechanoreceptor evolution
Revilla-i-Domingo, R.; Rajan, V. B. V.; Waldherr, M.; Prohaczka, G.; Musset, H.; Orel, L.; Gerrard, E.; Smolka, M.; Farlik, M.; Lucas, R. J.; Raible, F.; Tessmar-Raible, K.
10.1101/2021.01.10.426124 — developmental biology — Posted on 2021-01-12
2843 Exo-β-N-acetylmuramidase NamZ of Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidase
Müller, M.; Calvert, M.; Hottmann, I.; Kluj, R. M.; Teufel, T.; Balbuchta, K.; Engelbrecht, A.; Selim, K. A.; Xu, Q.; Borisova, M.; Titz, A.; Mayer, C.
10.1101/2021.01.10.425899 — microbiology — Posted on 2021-01-12
2845 Function of the HYDROXYCINNAMOYL-CoA:SHIKIMATE HYDROXYCINNAMOYL TRANSFERASE is evolutionarily conserved in embryophytes
Kriegshauser, L.; Knosp, S.; Grienenberger, E.; Tatsumi, K.; Gütle, D. D.; Sorensen, I.; Herrgott, L.; Zumsteg, J.; Rose, J. K. C.; Reski, R.; Werck, D.; Renault, H.
10.1101/2020.09.16.300285 — plant biology — Posted on 2021-01-12
2847 Mitofusins Mfn1 and Mfn2 are required in the β-cell to preserve mitochondrial architecture and insulin secretion
Georgiadou, E.; Muralidharan, C.; Martinez, M.; Chabosseau, P.; Tomas, A.; Wern, F. Y. S.; Stylianides, T.; Wretland, A.; Legido-Quigley, C.; Alsabeeh, N.; Cruciani-Guglielmacci, C.; Magnan, C.; Ibberson, M.; Leclerc, I.; Ali, Y.; Linnemann, A. K.; Rodriguez, T. A.; Rutter, G. A.
10.1101/2020.04.22.055384 — molecular biology — Posted on 2021-01-12
2851 The genome of a daddy-long-legs (Opiliones) illuminates the evolution of arachnid appendages and chelicerate genome architecture
Gainett, G.; Gonzalez, V. L.; Ballesteros, J. A.; Setton, E. V. W.; Baker, C. M.; Barolo Gargiulo, L.; Santibanez-Lopez, C. E.; Coddington, J. E.; Sharma, P. P.
10.1101/2021.01.11.426205 — developmental biology — Posted on 2021-01-12
2852 The genetic landscape of Ethiopia: diversity, intermixing and the association with culture
Lopez, S.; Tarekegn, A.; Band, G.; van Dorp, L.; Bird, N.; Morris, S.; Oljira, T.; Mekonnen, E.; Bekele, E.; Blench, R.; Thomas, M. G.; Bradman, N.; Hellenthal, G.
10.1101/756536 — genetics — Posted on 2021-01-12
2853 Chemical probe-based Nanopore Sequencing to Selectively Assess the RNA modifications
Ramasamy, S.; Sahayasheela, V. J.; Yu, Z.; Hidaka, T.; Cai, L.; Sugiyama, H.; Pandian, G. N.
10.1101/2020.05.19.105338 — synthetic biology — Posted on 2021-01-12
2856 Single Cell Enhancer Activity Maps Neuronal Lineages in Embryonic Mouse Basal Ganglia
Su-Feher, L.; Rubin, A.; Silberberg, S.; Catta-Preta, R.; Lim, K. J.; Zdilar, I.; McGinnis, C. S.; McKinsey, G.; Rubino, T. A.; Hawrylycz, M.; Thompson, C.; Gartner, Z. J.; Puelles, L.; Zeng, H.; Rubenstein, J. L. R.; Nord, A. S.
10.1101/2021.01.11.426285 — neuroscience — Posted on 2021-01-12
2857 Increased cortical volume without increased neuron number in heterozygous Chd8 mutant mouse cortex
Canales, C. P.; Frank, S.; Bennett, J.; Beauregard, P.; Lavenex, P.; Amaral, D. G.; Nord, A. S.
10.1101/2021.01.11.426290 — neuroscience — Posted on 2021-01-12
2859 Biop-C: A Method for Chromatin Interactome Analysis of Solid Cancer Needle Biopsy Samples
Animesh, S.; Choudhary, R.; Ng, X. Y.; Tay, J. k. X.; Chong, W.-Q.; Goh, B. C.; Fullwood, M.
10.1101/2021.01.11.426176 — genomics — Posted on 2021-01-12
2860 Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Schwachman-Diamond syndrome
Lee, S.; Shin, C. H.; Lee, J.; Jeong, S. D.; Hong, C. R.; Kim, J.-D.; Kim, A.-R.; Son, S. J.; Kokhan, O.; Yoo, T.; Ko, J. S.; Sohn, Y. B.; Kim, O.-H.; Ko, J. M.; Cho, T.-J.; Wright, N. T.; Seong, J. K.; Jin, S.-W.; Kang, H. J.; Kim, H. H.; Choi, M.
10.1101/483362 — genetics — Posted on 2021-01-12
2862 Neuromolecular and behavioral effects of ethanol deprivation in Drosophila
D'Silva, N. M.; McCullar, K. S.; Conard, A. M.; Blackwater, T.; Azanchi, R.; Heberlein, U.; Larschan, E. M.; Kaun, K. R.
10.1101/2021.01.02.425101 — neuroscience — Posted on 2021-01-12
2863 Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons
Kelley, C.; Dura-Bernal, S.; Neymotin, S. A.; Antic, S. D.; Carnevale, N. T.; Migliore, M.; Lytton, W. W.
10.1101/2021.01.08.425962 — neuroscience — Posted on 2021-01-12
2864 Robust Inference of Kinase Activity using Functional Networks
Yilmaz, S.; Ayati, M.; Schlatzer, D.; Cicek, A. E.; Chance, M.; Koyuturk, M.
10.1101/2020.05.01.062802 — systems biology — Posted on 2021-01-12
2869 Dissecting lipid contents in the distinct regions of native retinal rod disk membranes
Sander, C. L.; Sears, A. E.; Pinto, A. F. M.; Choi, E. H.; Kahremany, S. L.; Jin, H. G.; Suh, S.; Pardon, E.; Dong, Z.; Steyaert, J.; Saghatelian, A.; Skowronska-Krawczyk, D.; Kiser, P. D.; Palczewski, K.
10.1101/2021.01.11.426250 — cell biology — Posted on 2021-01-11
2870 Restored TDCA and Valine Levels Imitate the Effects of Bariatric Surgery
Tullius, S. G.; Quante, M.; Iske, J.; Heinbokel, T.; Desai, B. N.; Biefer, H. R. C.; Nian, Y.; Krenzien, F.; Uehara, H.; Maenosono, R.; Azuma, H.; Pratschke, J.; Falk, C.; Lo, T.; Sheu, E.; Tavakkoli, A.; Perkins, D.; Alegre, M.-L.; Banks, A. S.; Elkhal, A.
10.1101/2021.01.11.425291 — cell biology — Posted on 2021-01-12
2871 Myofibrillar Structural Variability Underlies Contractile Function in Stem Cell-Derived Cardiomyocytes
Ufford, K.; Friedline, S.; Tong, Z.; Tang, V. T.; Dobbs, A. S.; Tsan, Y.-C.; Bielas, S. L.; Liu, A. P.; Helms, A. S.
10.1101/2020.10.13.336685 — cell biology — Posted on 2021-01-12
2872 The kidney protects against sepsis by enhancing the systemic release of Uromodulin to stimulate macrophage function
LaFavers, K.; Hage, C.; Gaur, V.; Micanovic, R.; Hato, T.; Khan, S.; Winfree, S.; Doshi, S.; Moorthi, R.; Twigg, H.; Wu, X.-R.; Dagher, P.; Srour, E.; El-Achkar, T. M.
10.1101/2021.01.08.425960 — immunology — Posted on 2021-01-12
2873 Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit
Yong, X. L. H.; Zhang, L.; Yang, L.; Chen, X.; Yu, X.; Chandra, M.; Livingstone, E.; Tan, J. Z. A.; Widagdo, J.; Vieira, M. M.; Roche, K. W.; Lynch, J. W.; Keramidas, A.; Collins, B. M.; Anggono, V.
10.1101/2021.01.11.425709 — neuroscience — Posted on 2021-01-11
2879 Niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica
Knodler, L.; Powers, T. R.; Haeberle, A. L.; Hammarlöf, D. L.; Cundiff, J. A.; Predeus, A. V.; Hokamp, K.; Hinton, J. C. D.
10.1101/2021.01.11.426201 — microbiology — Posted on 2021-01-11
2880 Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome
Andino, R.; Shirogane, Y.; Rousseau, E.; Voznica, J.; Xiao, Y.; Su, W.; Catching, A.; Whitfiled, Z. J.; Rouzine, I. M.; Bianco, S.
10.1101/2021.01.11.426198 — microbiology — Posted on 2021-01-11
2881 Low-pathogenic virus induced immunity against TBEV protects mice from disease but not from virus entry into the CNS
Petry, M.; Palus, M.; Leitzen, E.; Mitterreiter, J. G.; Huang, B.; Kröger, A.; Verjans, G. M. G. M.; Baumgärtner, W.; Rimmelzwaan, G. F.; Ruzek, D.; Osterhaus, A.; Prajeeth, C.
10.1101/2021.01.11.426200 — immunology — Posted on 2021-01-11
2884 Dietary electrolyte balance on serum hematological and biochemical parameters of broilers under heat stress
SILVA, D.; Moura, F. A. d. S.; Lima, V. B. d. S.; Lopes, P. M.; Cardoso, J. d. F. S.; Prado, A. C. d.; Machado, L. P.; Sousa, R. A. d.; Biagiotti, D.; Dourado, L. R. B.
10.1101/2021.01.11.426185 — zoology — Posted on 2021-01-11
2886 Fecal microbial transplant abates tolerance to methylone-induced hyperthermia
Goldsmith, R.; Aburahma, A.; Pachhain, S.; Choudhury, S. R.; Phuntumart, V.; Larsen, R.; Sprague, J. E.
10.1101/2021.01.11.426194 — pharmacology and toxicology — Posted on 2021-01-11
2889 Sustained IL-15 response signature predicts RhCMV/SIV vaccine efficacy
Barrenäs, F.; Hansen, S. G.; Law, L.; Driscoll, C.; Green, R. R.; Smith, E.; Chang, J.; Golez, I.; Urion, T.; Peng, X.; Whitmore, L.; Newhouse, D.; Hughes, C. M.; Morrow, D.; Randall, K. T.; Selseth, A.; Ford, J. C.; Gilbride, R. M.; Randall, B.; Ainslie, E.; Oswald, K.; Shoemaker, R.; Fast, R.; Bosche, W. J.; Axthelm, M. K.; Fukazawa, Y.; Pavlakis, G. N.; Felber, B. K.; Fourati, S.; Sekaly, R.-P.; Lifson, J. D.; Komorowski, J.; Kosmider, E.; Shao, J.; Song, W.; Edlefsen, P. T.; Picker, L. J.; Gale, M.
10.1101/2021.01.11.426199 — genomics — Posted on 2021-01-11
2896 Gradual evolution of allopolyploidy in Arabidopsis suecica
Burns, R.; Mandakova, T.; Jagoda, J.; Soto-Jimenez, L. M.; Liu, C.; Lysak, M. A.; Novikova, P. Y.; Nordborg, M.
10.1101/2020.08.24.264432 — evolutionary biology — Posted on 2021-01-11
2897 Split Staphylococcus aureus prime editor for AAV delivery
Aird, E. J.; Zdechlik, A. C.; Ruis, B. L.; Rogers, C. B.; Lemmex, A. L.; Nelson, A. T.; Hendrickson, E. A.; Schmidt, D.; Gordon, W. R.
10.1101/2021.01.11.426237 — molecular biology — Posted on 2021-01-11
2898 Controlled spatial organization of bacterial clusters reveals cell filamentation is vital for Xylella fastidiosa biofilm formation
Anbumani, S.; da Silva, A. M.; Fischer, E. R.; de Souza e Silva, M.; von Zuben, A. A. G.; Carvalho, H. F.; de Souza, A. A.; Janissen, R.; Cotta, M. A.
10.1101/2021.01.08.425936 — microbiology — Posted on 2021-01-11
2899 Characterization of 475 novel, putative small RNAs (sRNAs) in Carbon-starved Salmonella enterica serovar typhimurium
Houserova, D. M.; Dahmer, D. J.; Amin, S. V.; King, V. M.; Barnhill, E. C.; Huang, Y.; Zambrano, M. E.; Dean, M. A.; crucello, a.; Aria, K. M.; Spector, M. P.; Borchert, G. M.
10.1101/2021.01.11.426214 — microbiology — Posted on 2021-01-11
2901 High-content analysis and Kinetic Image Cytometry identify toxic and epigenotoxic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells
Smith, A. S.; Ankam, S.; Farhy, C.; Fiengo, L.; Basa, R. C. B.; Gordon, K. L.; Martin, C. T.; Terskikh, A. V.; Jordan-Sciutto, K. L.; Price, J. H.; McDonough, P. M.
10.1101/2020.09.05.284422 — neuroscience — Posted on 2021-01-11
2902 Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage
Hsieh, C.; Tsokas, P.; Grau-Perales, A.; Lesburgueres, E.; Bukai, J.; Khanna, K.; Chorny, J.; Chung, A.; Jou, C.; Burghardt, N. S.; Denny, C. A.; Flores-Obando, R. E.; Hartley, B. R.; Valencia, L. M. R.; Hernandez, A. I.; Bergold, P. J.; Cottrell, J. E.; Alarcon, J. M.; Fenton, A. A.; Sacktor, T. C.
10.1101/2020.02.05.936146 — neuroscience — Posted on 2021-01-11
2904 The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models
Davies, S. P.; Mycroft-West, C. J.; Pagani, I.; Hill, H. J.; Chen, Y.-H.; Karlsson, R. T.; Bagdonaite, I.; Guimond, S. E.; Stamataki, Z.; Lima, M. A.; Turnbull, J. E.; Yang, Z.; Vicenzi, E. E.; Skidmore, M. A.; Khanim, F.; Richardson, A.
10.1101/2021.01.10.426114 — pharmacology and toxicology — Posted on 2021-01-11
2907 Use of the p-value as a size-dependent function to address practical differences when analyzing large datasets
Gomez-de-Mariscal, E.; Guerrero, V.; Sneider, A.; Jayatilaka, H.; Phillip, J. M.; Wirtz, D.; Munoz-Barrutia, A.
10.1101/2019.12.17.878405 — bioinformatics — Posted on 2021-01-11
2915 The evolutionary assembly of forest communities along environmental gradients: recent diversification or sorting of pre-adapted clades?
Linan, A. G.; Myers, J. A.; Edwards, C. E.; Zanne, A. E.; Smith, S. A.; Arellano, G.; Cayola, L.; Farfan-Rios, W.; Fuentes, A. F.; Garcia-Cabrera, K.; Gonzales-Caro, S.; Loza, M. I.; Macia, M. J.; Malhi, Y.; Nieto-Ariza, B.; Salinas, N.; Silman, M. R.; Tello, S. J.
10.1101/2020.12.22.424032 — ecology — Posted on 2021-01-11
2921 Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques
van Doremalen, N.; Purushotham, J.; Schulz, J.; Holbrook, M.; Bushmaker, T.; Carmody, A.; Port, J.; Yinda, K. C.; Okumura, A.; Saturday, G.; Amanat, F.; Krammer, F.; Hanley, P.; Smith, B.; Lovaglio, J.; Anzick, S.; Barbian, K.; Martens, C.; Gilbert, S. C.; Lambe, T.; Munster, V.
10.1101/2021.01.09.426058 — microbiology — Posted on 2021-01-11
2923 COVID-19 Severity Is Associated with Differential Antibody Fc-mediated Innate Immune Functions
Adeniji, O. S.; Giron, L. B.; Zilberstein, N. F.; Shaikh, M. W.; Balk, R. A.; Moy, J. N.; Forsyth, C. B.; Keshavarzian, A.; Landay, A. L.; Abdel-Mohsen, M.
10.1101/2021.01.11.426209 — microbiology — Posted on 2021-01-11
2924 Alterations in gut microbiota linked to provenance, sex, and chronic wasting disease in white-tailed deer (Odocoileus virginianus)
Minich, D.; Madden, C.; Evans, M. V.; Ballash, G. A.; Barr, D. J.; Poulsen, K. P.; Dennis, P. M.; Hale, V. L.
10.1101/2021.01.11.426270 — microbiology — Posted on 2021-01-11
2925 Dynamic pneumococcal genetic adaptations support bacterial growth and inflammation during coinfection with influenza
Smith, A. P.; Lane, L.; van Opijnen, T.; Woolard, S.; Carter, R.; Iverson, A.; Burnham, C.; Vogel, P.; Roeber, D.; Hochu, G.; Johnson, M. D.; McCullers, J.; Rosch, J.; Smith, A. M.
10.1101/659557 — microbiology — Posted on 2021-01-11
2926 Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA SARS 2 S in preclinical vaccination
Tscherne, A.; Schwarz, J. H.; Rohde, C.; Kupke, A.; Kalodimou, G.; Limpinsel, L.; Okba, N. M. A.; Bosnjak, B.; Sandrock, I.; Halwe, S.; Sauerhering, L.; Printz, K.; Nan, L.; Duell, E.; Jany, S.; Freudenstein, A.; Schmidt, J.; Werner, A.; Gellhorn, M.; Kluever, M.; Guggemos, W.; Seilmaier, M.; Wendtner, C.; Foerster, R.; Haagmans, B.; Becker, S.; Sutter, G.; Volz, A.
10.1101/2021.01.09.426032 — microbiology — Posted on 2021-01-11
2927 RUNX1 controls the dynamics of cell cycle entry of naive resting B cells by regulating expression of cell cycle and immunomodulatory genes in response to BCR stimulation
Thomsen, I.; Kunowska, N.; de Souza, R.; Moody, A.-M.; Crawford, G.; Wang, Y.-F.; Khadayate, S.; Strid, J.; Karimi, M. M.; Barr, A.; Dillon, N.; Sabbattini, P.
10.1101/2020.12.01.406744 — immunology — Posted on 2021-01-11
2929 Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class
Rapp, M.; Guo, Y.; Reddem, E. R.; Liu, L.; Wang, P.; Yu, J.; Cerutti, G.; Bimela, J.; Bahna, F.; Mannepalli, S.; Zhang, B.; Kwong, P. D.; Ho, D. D.; Shapiro, L.; Sheng, Z.
10.1101/2021.01.11.426218 — immunology — Posted on 2021-01-11
2931 Immunogenicity and Protective Efficacy of an Intranasal Live-attenuated Vaccine Against SARS-CoV-2 in Preclinical Animal Models
Park, J.-G.; Oladunni, F. S.; Rohaim, M. A.; Whittingham-Dowd, J.; Tollitt, J.; Assas, B. M.; Alhazmi, W.; Almilaibary, A.; Iqbal, M.; Chang, P.; Escalona, R.; Shivanna, V.; Torrelles, J. B.; Worthington, J. J.; Jackson-Jones, L. H.; Martinez-Sobrido, L.; Munir, M.
10.1101/2021.01.08.425974 — immunology — Posted on 2021-01-11
2933 Neuron-type specificity of dorsal raphe projections to ventral tegmental area
Chang, A. J.; Wang, L.; Lucantonio, F.; Adams, M.; Lemire, A. L.; Dudman, J. T.; Cohen, J. Y.
10.1101/2021.01.06.425641 — neuroscience — Posted on 2021-01-11
2934 In vivo visualization of pig vagus nerve 'vagotopy' using ultrasound
Settell, M. L.; Kasole, M.; Skubal, A. C.; Knudsen, B. E.; Nicolai, E. N.; Huang, C.; Zhou, C.; Trevathan, J. K.; Pelot, N. A.; Grill, W. M.; Upadhye, A.; Kolluru, C.; Shoffstall, A. J.; Williams, J. C.; Suminski, A. J.; Chen, S.; Ludwig, K. A.
10.1101/2020.12.24.424256 — neuroscience — Posted on 2021-01-11
2935 Orbitofrontal cortex and learning predictions of state transitions
Chan, S. C. Y.; Schuck, N. W.; Lopatina, N.; Schoenbaum, G.; Niv, Y.
10.1101/2020.09.17.302521 — neuroscience — Posted on 2021-01-11
2936 Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility
Korn, C.; Akam, T.; Jensen, K. H. R.; Vagnoni, C.; Huber, A.; Tunbridge, E. M.; Walton, M. E.
10.1101/823401 — neuroscience — Posted on 2021-01-11
2939 Unfolding the Apoptotic Mechanism of Antioxidant Enriched-Leaves of Tabebuia pallida in EAC Cells
Alam, A. K.; Rahman, M. M.; Khan, M. A.; Reza, A. S. M. A.; Sujon, K. M.; Sharmin, R.; Rashid, M.; Sadik, M. G.; Reza, M. A.; Tsukahara, T.; Mosaddik, A.; Gobe, G. C.
10.1101/2021.01.11.426226 — cancer biology — Posted on 2021-01-11
2942 Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Saker channel
Silvera Ejneby, M.; Gromova, A.; Ottosson, N. E.; Borg, S.; Estrada-Mondragon, A.; Yazdi, S.; Apostolakis, P.; Elinder, F.; Delemotte, L.
10.1101/2020.06.11.146548 — biophysics — Posted on 2021-01-11
2945 Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite
Cerutti, G.; Guo, Y.; Zhou, T.; Gorman, J.; Lee, M.; Rapp, M.; Reddem, E. R.; Yu, J.; Bahna, F.; Bimela, J.; Huang, Y.; Katsamba, P. S.; Lihong, L.; Nair, M. S.; Rawi, R.; Olia, A. S.; Wang, P.; Chuang, G.-Y.; Ho, D. D.; Sheng, Z.; Kwong, P. D.; Shapiro, L.
10.1101/2021.01.10.426120 — biochemistry — Posted on 2021-01-11
2949 Rapid Online Assessment of Reading Ability
Yeatman, J. D.; Tang, K. A.; Donnelly, P. M.; Yablonski, M.; Ramamurthy, M.; Karipidis, I. I.; Caffarrra, S.; Takada, M. E.; Kanopka, K.; Ben-Shachar, M.; Domingue, B. W.
10.1101/2020.07.30.229658 — animal behavior and cognition — Posted on 2021-01-11
2950 Massive colonization of protein-coding exons by selfish genetic elements in Paramecium germline genomes
Sellis, D.; Guerin, F.; Arnaiz, O.; Pett, W.; Lerat, E.; Boggetto, N.; Krenek, S.; Berendonk, T.; Couloux, A.; Aury, J.-M.; Labadie, K.; Malinski, S.; Meyer, E.; Sperling, L.; Duret, L.; Duharcourt, S.
10.1101/2020.12.23.424184 — genomics — Posted on 2021-01-11
2957 Free-fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice
Croze, M. L.; Flisher, M.; Guillaume, A.; Tremblay, C.; Noguchi, G. M.; Granziera, S.; Vivot, K.; Castillo, V. C.; Campbell, S. A.; Ghislain, J.; Huising, M. O.; Poitout, V.
10.1101/2020.07.17.208637 — cell biology — Posted on 2021-01-11
2958 Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2 and heparan sulfate
Prieto-Fernandez, E.; Egia-Mendikute, L.; Vila-Vecilla, L.; Lee, S. Y.; Bosch, A.; Barreira-Manrique, A.; Garcia del Rio, A.; Antonana-Vildosola, A.; Jimenez-Lasheras, B.; Palazon, A.
10.1101/2021.01.09.426021 — cell biology — Posted on 2021-01-11
2960 Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster
Rizvi, Z. A.; Dalal, R.; Sadhu, S.; Kumar, Y.; Shrivastava, T.; Gupta, S. K.; Aggarwal, S.; Tripathy, M. R.; Yadav, A. K.; Medigeshi, G. R.; Pandey, A. K.; Samal, S.; Asthana, S.; Awasthi, A.
10.1101/2021.01.11.426080 — microbiology — Posted on 2021-01-11
2962 The landscape of human brain immune response in patients with severe COVID-19
Fullard, J. F.; Lee, H.-c.; Voloudakis, G.; Suo, S.; Shao, Z.; Peter, C.; Javidfar, B.; Zhang, W.; Jiang, S.; Corvelo, A.; Woodoff-Leith, E.; Purohit, D. P.; Hoffman, G. E.; Akbarian, S.; Fowkes, M.; Crary, J.; Yuan, G.-C.; Roussos, P.
10.1101/2021.01.08.425999 — neuroscience — Posted on 2021-01-11
2965 Unique brewing-relevant properties of a strain of Saccharomyces jurei isolated from ash (Fraxinus excelsior)
Hutzler, M.; Michel, M.; Kunz, O. S.; Kuusisto, T.; Magalhaes, F.; Krogerus, K.; Gibson, B.
10.1101/2021.01.11.426216 — microbiology — Posted on 2021-01-11
2967 Chronic SSRI treatment reverses HIV-1 protein-mediated synaptodendritic damage
Denton, A. R.; Mactutus, C. F.; Lateef, A. U.; Harrod, S. B.; Booze, R. M.
10.1101/2021.01.11.426213 — neuroscience — Posted on 2021-01-11
2972 CoronaHiT: High throughput sequencing of SARS-CoV-2 genomes
Baker, D. J.; Aydin, A.; Le-Viet, T.; Kay, G. L.; Rudder, S.; Martins, L. d. O.; Tedim, A. P.; Kolyva, A.; Diaz, M.; Alikhan, N.-F.; Meadows, L.; Bell, A.; Gutierrez, A. V.; Trotter, A. J.; Thomson, N. M.; Gilroy, R.; Griffith, L.; Adriaenssens, E. M.; Stanley, R.; Charles, I. G.; Elumogo, N.; Wain, J.; Prakash, R.; Meader, E.; Mather, A. E.; Webber, M. A.; Dervisevic, S.; Page, A. J.; O'Grady, J.
10.1101/2020.06.24.162156 — genomics — Posted on 2021-01-11
2973 Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
Liu, Z.; VanBlargan, L. A.; Bloyet, L.-M.; Rothlauf, P. W.; Chen, R. E.; Stumpf, S.; Zhao, H.; Errico, J. M.; Theel, E. S.; Liebeskind, M. J.; Alford, B.; Buchser, W. J.; Ellebedy, A. H.; Fremont, D. H.; Diamond, M. S.; Whelan, S. P. J.
10.1101/2020.11.06.372037 — microbiology — Posted on 2021-01-11
2974 Synergistic interferon alpha-based drug combinations inhibit SARS-CoV-2 and other viral infections in vitro
Ianevski, A.; Yao, R.; Zusinaite, E.; Lello, L. S.; Wang, S.; Jo, E.; Yang, J.; Lysvand, H.; Loseth, K.; Oksenych, V.; Tenson, T.; Windisch, M. P.; Poranen, M.; Nieminen, A. I.; Nordbo, S. A.; Fenstad, M. H.; Grodeland, G.; Aukrust, P.; Troseid, M.; Kantele, A.; Merits, A.; Bjoras, M.; Kainov, D. E.
10.1101/2021.01.05.425331 — microbiology — Posted on 2021-01-11
2975 Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
Rosenfeld, R.; Noy-Porat, T.; Mechaly, A.; Makdasi, E.; Levy, Y.; Alcalay, R.; Falach, R.; Aftalion, M.; Epstein, E.; Gur, D.; Chitlaru, T.; Vitner, E. B.; Melamed, S.; Politi, B.; Zauberman, A.; Lazar, S.; Beth-Din, A.; Evgy, Y.; Yitzhaki, S.; Shapira, S. C.; Israely, T.; Mazor, O.
10.1101/2020.10.26.354811 — immunology — Posted on 2021-01-11
2979 24-Nor-Ursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation
Zhu, C.; Boucheron, N.; Mueller, A. C.; Majek, P.; Claudel, T.; Halilbasic, E.; Baazim, H.; Lercher, A.; Viczenczova, C.; Hainberger, D.; Preglej, T.; Sandner, L.; Alteneder, M.; Guelich, A. F.; Khan, M.; Hamminger, P.; Remetic, J.; Ohradanova-Repic, A.; Schatzlmaier, P.; Donner, C.; Fuchs, C.; Stojakovic, T.; Scharnagl, H.; Sakaguchi, S.; Weichhart, T.; Bergthaler, A.; Stockinger, H.; Ellmeier, W.; Trauner, M.
10.1101/2021.01.09.426037 — molecular biology — Posted on 2021-01-11
2980 DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy
Baldwin, L. A.; Bartonicek, N.; Yang, J.; Wu, S. Z.; Deng, N.; Roden, D. L.; Chan, C.-L.; Al-Eryani, G.; Swarbrick, A.; Junankar, S.
10.1101/2021.01.11.426174 — cancer biology — Posted on 2021-01-11
2984 Heme auxotrophy in abundant aquatic microbial lineages
Kim, S.; Kang, I.; Lee, J.-W.; Jeon, C.-O.; Giovannoni, S. J.; Cho, J.-C.
10.1101/2021.01.11.426183 — microbiology — Posted on 2021-01-11
2985 Chemical interplay and complementary adaptative strategies toggle bacterial antagonism and co-existence
Molina-Santiago, C.; Vela-Corcia, D.; Petras, D.; Diaz-Martinez, L.; Perez-Lorente, A.; Sopena-Torres, S.; Pearson, J. R.; Caraballo-Rodriguez, A. M.; Dorrestein, P.; de Vicente, A.; romero, d.
10.1101/2021.01.11.426172 — microbiology — Posted on 2021-01-11
2987 Cell-Free Characterization of Coherent Feed-Forward Loop-Based Synthetic Genetic Circuit
Pieters, P. A.; Nathalia, B. L.; van der Linden, A. J.; Yin, P.; Kim, J.; Huck, W. T. S.; de Greef, T. F. A.
10.1101/2021.01.11.426179 — synthetic biology — Posted on 2021-01-11
2988 The Flowering Time Regulator FLK Controls Pathogen Defense in Arabidopsis thaliana
Fabian, M.; Gao, M.; Zhang, X.-N.; Shi, J.; Kim, S.-H.; Patel, P.; Hu, A. R.; Lu, H.
10.1101/2021.01.10.426133 — plant biology — Posted on 2021-01-11
2989 The pathway of starch synthesis in Arabidopsis thaliana leaves
Fünfgeld, M. M. F. F.; Wang, W.; Ishihara, H.; Arrivault, S.; Feil, R.; Smith, A. M.; Stitt, M.; Lunn, J.; Niittylä, T.
10.1101/2021.01.11.426159 — plant biology — Posted on 2021-01-11
2992 Hydroxyapatite pellets as versatile model surfaces for systematic studies on enamel
Mischo, J.; Faidt, T.; McMillan, R. B.; Dudek, J.; Gunaratnam, G.; Bayenat, P.; Holtsch, A.; Spengler, C.; Mueller, F.; Haehl, H.; Bischoff, M.; Hannig, M.; Jacobs, K.
10.1101/2021.01.11.426207 — biophysics — Posted on 2021-01-11
2995 COT: an efficient Python tool for detecting marker genes among many subtypes
Lu, Y.; Wu, C.-T.; Parker, S. J.; Chen, L.; Saylor, G.; Van Eyk, J. E.; Herrington, D. M.; Wang, Y.
10.1101/2021.01.10.426146 — bioinformatics — Posted on 2021-01-11
2998 Deciphering 3D Human Sphygmopalpation Pulse Patterns using "X-ray" Images Acquired from Tactile Robotic Fingers
KONG, K. W.; CHAN, H.-y.; XIE, J.; LEE, F. C. S.; LEUNG, A. Y. L.; GUAN, B.; SHEN, J.; TAAM WONG, V. C.-W.; LI, W. J.
10.1101/2021.01.10.426152 — bioengineering — Posted on 2021-01-11
2999 Biop-C: A Method for Chromatin Interactome Analysis of Solid Cancer Needle Biopsy Samples
Fullwood, M.; Animesh, S.; Choudhary, R.; Goh, B. C.; Tay, J.; chong, w.-q.; Ng, X. Y.
10.1101/2021.01.11.426176 — genomics — Posted on 2021-01-11
3002 Genetic diversity, distribution and domestication history of the neglected GGAtAt genepool of wheat
Badaeva, E. D.; Konovalov, F. A.; Knuepffer, H.; Fricano, A.; Ruban, A. S.; Kehel, Z.; Zoshchuk, S. A.; Surzhikov, S. A.; Neumann, K.; Graner, A.; Hammer, K.; Filatenko, A. A.; Bogaard, A.; Jones, G.; Ozkan, H.; Kilian, B.
10.1101/2021.01.10.426084 — evolutionary biology — Posted on 2021-01-11
3006 Nuclear m6A reader Ythdc1 regulates the scaffold function of LINE1 in mouse ESCs
Chen, C.; Liu, W.; Guo, J.; Liu, Y.; Liu, X.; Liu, J.; Dou, X.; Le, R.; Huang, Y.; Li, C.; Yang, L.; Kou, X.; Zhao, Y.; Wu, Y.; Chen, J.; Wang, H.; Shen, B.; Gao, Y.; Gao, S.
10.1101/2021.01.10.426065 — cell biology — Posted on 2021-01-11
3008 Recovery of high-quality assembled genomes via single-cell genome-guided binning of metagenome assembly
Arikawa, K.; Ide, K.; Kogawa, M.; Saeki, T.; Yoda, T.; Endoh, T.; Matsuhashi, A.; Takeyama, H.; Hosokawa, M.
10.1101/2021.01.11.425816 — microbiology — Posted on 2021-01-11
3009 Distinct T cell chromatin landscapes in scleroderma subtypes
Dou, D. R.; Zhao, Y.; Abe, B.; Li, R.; Zaba, L. C.; Aren, K.; Carns, M.; Chung, L. S.; Hinchcliff, M.; Chang, H. Y.
10.1101/2021.01.10.426131 — immunology — Posted on 2021-01-11
3010 IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii
Clark, J. T.; Christian, D. A.; Gullicksrud, J.; Perry, J. A.; Park, J.; Jacquet, M.; Tarrant, J. C.; Radaelli, E.; Silver, J.; Hunter, C. A.
10.1101/2021.01.10.426122 — immunology — Posted on 2021-01-11
3013 Cepo uncovers cell identity through differential stability
Kim, J. H.; Wang, K. Y.; Chen, C.; Lin, Y.; Tam, P. P.; Lin, D. M.; Yang, J. Y. H.; Yang, P.
10.1101/2021.01.10.426138 — systems biology — Posted on 2021-01-11
3018 Inter- and intra-specific variation in hair cortisol concentrations of Neotropical bats
Sandoval Herrera, N. I.; Mastromonaco, G.; Becker, D.; Simmons, N. B.; Welch, K. C.
10.1101/2021.01.10.426004 — ecology — Posted on 2021-01-11
3019 Local genetic context shapes the function of a gene regulatory network
Nagy-Staron, A.; Tomasek, K.; Caruso Carter, C.; Sonnleitner, E.; Kavcic, B.; Paixao, T.; Guet, C. C.
10.1101/2021.01.10.426121 — molecular biology — Posted on 2021-01-11
3020 A non-adaptive demographic mechanism for genome expansion in Streptomyces
Choudoir, M. J.; Järvenpää, M. J.; Marttinen, P.; Buckley, D. H.
10.1101/2021.01.09.426074 — microbiology — Posted on 2021-01-11
3021 Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition
Yan, L.; Tu, B.; Yao, J.; Gong, J.; Carugo, A.; Bristow, C.; Wang, Q.; Zhu, C.; Dai, B.; Kang, Y.; Han, L.; Feng, N.; Jin, Y.; Fleming, J.; Heffernan, T.; Yao, W.; Ying, H.
10.1101/2021.01.09.425923 — cancer biology — Posted on 2021-01-11
3022 Late Pleistocene palaeoecology and phylogeography of woolly rhinoceroses
Rey-Iglesia, A.; Lister, A. M.; Stuart, A. J.; Bocherens, H.; Szpak, P.; Willerslev, E.; Lorenzen, E. D.
10.1101/2021.01.08.425884 — evolutionary biology — Posted on 2021-01-11
3023 X chromosome inactivation in the human placenta is patchy and distinct from adult tissues
Phung, T. N.; Olney, K. C.; Silasi, M.; Perley, L.; O'Bryan, J.; Kliman, H. J.; Wilson, M. A.
10.1101/785105 — genomics — Posted on 2021-01-11
3025 In-situ observation of mitochondrial biogenesis as the early event of apoptosis
Shao, C.-s.; Zhou, X.-H.; Miao, Y.-H.; Wang, P.; Zhang, Q.-q.; Huang, Q.
10.1101/2020.08.23.263152 — cell biology — Posted on 2021-01-11
3028 Assessing Study Reproducibility through MMRI: A Novel Approach for Large-scale High-throughput Association Studies
Jiao, Z.; Lai, Y.; Kang, J.; Gong, W.; Ma, L.; Jia, T.; Xie, C.; Cheng, W.; Heinz, A.; Desrivieres, S.; Schumann, G.; Sun, F.; Feng, J.
10.1101/2020.08.18.253740 — neuroscience — Posted on 2021-01-11
3029 Efficient GNE myopathy disease modeling with mutation specific phenotypes in human pluripotent stem cells by base editors
Park, J.-C.; Kim, J.; Jang, H.-K.; Lee, S.-Y.; Kim, K.-T.; Park, S.; Lee, H. S.; Choi, H.-J.; Park, S.-J.; Moon, S.-H.; Bae, S.; Cha, H.-J.
10.1101/2020.11.25.397711 — developmental biology — Posted on 2021-01-11
3030 Sex-specific lipid profiles in muscle of Atlantic salmon juveniles
House, A. H.; Primmer, C. R.; Debes, P. V.; Erkinaro, J.; Kakela, R.; Kurko, J.
10.1101/2020.11.13.379321 — molecular biology — Posted on 2021-01-11
3032 Vegetative phase change in Populus tremula x alba
Lawrence, E. H.; Leichty, A. R.; Doody, E. E.; Ma, C.; Strauss, S. H.; Poethig, R. S.
10.1101/2020.06.21.163469 — plant biology — Posted on 2021-01-11
3035 A simple Agrobacterium-mediated stable transformation technique for the hornwort model Anthoceros agrestis
Frangedakis, E.; Waller, M.; Nishiyama, T.; Tsukaya, H.; Xu, X.; Yue, Y.; Tjahjadi, M.; Gunadi, A.; Van Eck, J.; Li, F.-W.; Szovenyi, P.; Sakakibara, K.
10.1101/2021.01.07.425778 — plant biology — Posted on 2021-01-10
3036 In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography
Ghassabi, Z.; Kuranov, R.; Wu, M.; Tayebi, B. T.; Wang, Y.; Rubinoff, I.; Liu, X.; Wollstein, G.; Schuman, J. S.; Zhang, H. F.; Ishikawa, H.
10.1101/2021.01.08.425925 — bioengineering — Posted on 2021-01-10
3037 IgA Potentiates NETosis in Response to Viral Infection
Stacey, H. D.; Golubeva, D.; Posca, A.; Ang, J. C.; Novakowski, K. E.; Zahoor, M. A.; Kaushic, C.; Cairns, E.; Bowdish, D.; Mullarkey, C. E.; Miller, M. S.
10.1101/2021.01.04.424830 — immunology — Posted on 2021-01-10
3046 Petabyte-Scale Multi-Morphometry of Single Neurons for Whole Brains
Jiang, S.; Wang, Y.; Liu, L.; Zhao, S.; Chen, M.; Zhao, X.; Peng, X.; Ding, L.; Ruan, Z.; Dong, H.; Ascoli, G. A.; Hawrylycz, M.; Zeng, H.; Peng, H.
10.1101/2021.01.09.426010 — neuroscience — Posted on 2021-01-10
3049 VEGFA's distal enhancer regulates its alternative splicing in CML
Dahan, S.; Cohen, K.; Dentata, M.; Engal, E.; Siam, A.; Kay, G.; Drier, Y.; Elias, S.; Salton, M.
10.1101/2021.01.09.426072 — cancer biology — Posted on 2021-01-10
3051 Structural basis for Potassium transport by KdpFABC
Sweet, M. E.; Larsen, C.; Zhang, X.; Schlame, M.; Pedersen, B. P.; Stokes, D. L.
10.1101/2021.01.09.426067 — biophysics — Posted on 2021-01-10
3054 Poor adult nutrition impairs learning and memory in a parasitoid wasp
Kishani Farahani, H.; Moghaddassi, Y.; Pierre, J.-S.; Kraus, S.; Lihoreau, M.
10.1101/2021.01.09.426073 — animal behavior and cognition — Posted on 2021-01-10
3058 Estuarine molecular bycatch as a landscape-wide biomonitoring tool
Mariani, S.; Harper, L. R.; Collins, R. A.; Baillie, C.; Wangensteen, O.; McDevitt, A.; Heddell-Cowie, M.; Genner, M. J.
10.1101/2021.01.10.426097 — ecology — Posted on 2021-01-10
3067 Bioengineered embryoids mimic post-implantation development in vitro
Girgin, M.; Broguiere, N.; Hoehnel, S.; Brandenberg, N.; Mercier, B.; Martinez-Arias, A.; Lutolf, M. P.
10.1101/2021.01.10.426096 — developmental biology — Posted on 2021-01-10
3069 Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution
Wang, L.; Li, J.; He, S.; Chen, H.; He, S.; Yin, M.; Zou, D.; Xu, J.; Chen, S.; Luo, T.; Yu, X.; BEI, J.; Guo, Z.; He, X.
10.1101/2021.01.10.426087 — cell biology — Posted on 2021-01-10
3070 Time-Encoding Migrates from Prefrontal Cortex to Dorsal Striatum During Learning of a Self-Timed Response Duration Task
Chiuffa Tunes, G.; de Oliveira, E. F.; Vieira, E. U. P.; Caetano, M. S.; Cravo, A. M.; Reyes, M. B.
10.1101/2020.11.19.390286 — neuroscience — Posted on 2021-01-10
3073 CLAMP and Zelda function together as pioneer transcription factors to promote Drosophila zygotic genome activation
Duan, J. E.; Rieder, L.; Colonnetta, M. M.; Huang, A.; Mckenney, M.; Watters, S.; Deshpande, G.; Jordan, W.; Fawzi, N. L.; Larschan, E.
10.1101/2020.07.15.205054 — genomics — Posted on 2021-01-10
3076 Multimodal brain imaging study of 36,678 participants reveals adverse effects of moderate drinking
Daviet, R.; Aydogan, G.; Jagannathan, K.; Spilka, N.; Koellinger, P.; Kranzler, H. R.; Nave, G.; Wetherill, R.
10.1101/2020.03.27.011791 — neuroscience — Posted on 2021-01-10
3077 COMPARE, an ultra-fast and robust suite for multiparametric screening, identifies phenotypic drug responses in acute myeloid leukemia
Chalabi Hajkarim, M.; Karjalainen, E.; Osipovitch, M.; Dimopoulos, K.; Gordon, S. L.; Ambri, F.; Rasmussen, K. D.; Gronbaek, K.; Helin, K.; Wennerberg, K.; Won, K. J.
10.1101/2021.01.08.425880 — cancer biology — Posted on 2021-01-10
3078 Relationships between macro-fungal dark diversity and habitat parameters using LiDAR
Valdez, J.; Brunbjerg, A. K.; Flojgaard, C.; Dalby, L.; Clausen, K. K.; Pärtel, M.; Pfeifer, N.; Hollaus, M.; Wimmer, M. H.; Ejrnaes, R.; Moeslund, J. E.
10.1101/2020.07.02.185553 — ecology — Posted on 2021-01-10
3079 Bottom-up inputs are required for the establishment of top-down connectivity onto cortical layer 1 neurogliaform cells
Ibrahim, L. A.; Huang, S.; Fernandez-Otero, M.; Sherer, M.; Vemuri, S.; Xu, Q.; Machold, R.; Rudy, B.; Fishell, G.
10.1101/2021.01.08.425944 — neuroscience — Posted on 2021-01-10
3080 COMPARE, an ultra-fast and robust suite for multiparametric screening, identifies phenotypic drug responses in acute myeloid leukemia
Chalabi Hajkarim, M.; Karjalainen, E.; Osipovitch, M.; Dimopoulos, K.; Gordon, S. L.; Ambri, F.; Rasmussen, K. D.; Gronbaek, K.; Helin, K.; Wennerberg, K.; Won, K. J.
10.1101/2021.01.08.425880 — cancer biology — Posted on 2021-01-10
3081 Mechanistic inferences from analysis of measurements of protein phase transitions in live cells
Posey, A. E.; Ruff, K. M.; Lalmansingh, J. M.; Kandola, T. S.; Lange, J. J.; Halfmann, R.; Pappu, R. V.
10.1101/2020.11.04.369017 — biophysics — Posted on 2021-01-10
3082 MCPdb: The Bacterial Microcompartment Database
Ochoa, J. M.; Bair, K.; Holton, T.; Bobik, T. A.; Yeates, T. O.
10.1101/2021.01.09.426059 — bioinformatics — Posted on 2021-01-10
3084 Cortical Mechanisms of Saccadic Suppression
Denagamage, S.; Morton, M.; Reynolds, J.; Jadi, M.; Nandy, A.
10.1101/2021.01.09.426063 — neuroscience — Posted on 2021-01-09
3088 A framework to identify structured behavioral patterns within rodent spatial trajectories
Donnarumma, F.; Prevete, R.; Maisto, D.; Fuscone, S.; Irvine, E.; van der Meer, M.; Kemere, C.; Pezzulo, G.
10.1101/2020.03.02.967489 — animal behavior and cognition — Posted on 2021-01-09
3089 West Nile virus detection in horses in three Brazilian states.
Azevedo Costa, E.; Giovanetti, M.; Silva Catenacci, L.; Fonseca, V.; Aburjaile, F.; Melo Campos Iani, F.; da Cunha e Silva Vieira, M. A.; Freitas Henriques, D.; Barbosa de Almeida, D.; Maldonado Coelho Guedes, M. I.; Alvares da Silva Ramos, B. S.; Solimar Goncalves Silva, A.; de Oliveira, T.; Ribeiro Leite Jardim Cavalcante, K.; Oliveira de Moura, N. F.; Pecego Martins Romano, A.; Albuquerque, C. F. C. d.; Soares Feitosa, L. C.; Martins Bayeux, J. J.; Bertoni Cavalcanti Teixeira, R.; Lisboa Lobato, O.; da Costa Silva, S.; Lourenco, J.; Alcantara, L. C. J.
10.1101/2021.01.06.425363 — genomics — Posted on 2021-01-09
3093 The kidney protects against sepsis by enhancing the systemic release of Uromodulin to stimulate macrophage function
LaFavers, K.; Hage, C.; Gaur, V.; Micanovic, R.; Hato, T.; Khan, S.; Winfree, S.; Doshi, S.; Moorthi, R.; Twigg, H.; Wu, X.-R.; Dagher, P.; Srour, E.; El-Achkar, T. M.
10.1101/2021.01.08.425960 — immunology — Posted on 2021-01-09
3094 The Coherent Default Mode Network is not involved in Episodic Recall or Social Cognition
Jackson, R. L.; Humphreys, G. F.; Rice, G. E.; Binney, R. J.; Lambon Ralph, M. A.
10.1101/2021.01.08.425921 — neuroscience — Posted on 2021-01-09
3095 Decoupling of global brain activity and cerebrospinal fluid flow in Parkinson's cognitive decline
Han, F.; Brown, G. L.; Zhu, Y.; Belkin-Rosen, A. E.; Lewis, M. M.; Du, G.; Gu, Y.; Eslinger, P. J.; Mailman, R. B.; Huang, X.; Liu, X.
10.1101/2021.01.08.425953 — neuroscience — Posted on 2021-01-09
3097 Intrusive Experiences In Post-Traumatic Stress Disorder: Treatment Response Induces Changes In The Effective Connectivity Of The Anterior Insula
Leroy, A.; Very, E.; Birmes, P.; Szaffarczyk, S.; Lopes, R.; Faure, C.; Duhem, S.; Grandgenevre, P.; Warembourg, F.; Vaiva, G.; Jardri, R.
10.1101/2020.10.01.319269 — neuroscience — Posted on 2021-01-09
3098 Implicit motor learning within three trials
Ruttle, J. E.; t Hart, B. M.; Henriques, D. Y. P.
10.1101/2020.04.07.030189 — neuroscience — Posted on 2021-01-09
3099 The neural basis of effort valuation: A meta-analysis of functional magnetic resonance imaging studies
Lopez-Gamundi, P.; Yao, Y.-W.; Chong, T. T.-J.; Heekeren, H. R.; Mas Herrero, E.; Marco Pallares, J.
10.1101/2021.01.08.425909 — neuroscience — Posted on 2021-01-09
3105 Engineering neurovascular organoids with 3D printed microfluidic chips
Salmon, I.; Grebeniuk, S.; Abdel Fattah, A. R.; Rustandi, G.; Pilkington, T.; Verfaillie, C.; Ranga, A.
10.1101/2021.01.09.425975 — bioengineering — Posted on 2021-01-09
3107 The female pheromone (Z)-4-undecenal mediates flight attraction and courtship in Drosophila melanogaster
Borrero-Echeverry, F.; Solum, M.; Trona, F.; Wallin, E. A.; Bengtsson, M.; Witzgall, P.; Lebreton, S.
10.1101/2021.01.06.425638 — animal behavior and cognition — Posted on 2021-01-09
3108 Chikungunya virus ECSA lineage reintroduction in the northeasternmost region of Brazil
Xavier, J.; Fonseca, V.; Felipe Bezerra, J.; do Monte Alves, M.; Mares-Guia, M. A.; Claro, I.; de Jesus, R.; Adelino, T.; Araujo, E.; Ribeiro Leite Jardim Cavalcante, K.; Tosta, S.; Rocha de Souza, T.; Emanuelle Moreira da Cruz, F.; de Araujo Fabri, A.; de Oliveira, E. C.; Fabiana Oliveira de Moura, N.; Fabiano do Carmo Said, R.; Albuquerque, C. F. C. d.; Azevedo, V.; de Oliveira, T.; Bispo de Filippis, A. M.; Venancio Cunha, R.; Giovanni Luz, K.; Giovanetti, M.; Alcantara, L. C. J.
10.1101/2021.01.09.426024 — genomics — Posted on 2021-01-09
3110 Signatures of Mutational Processes in Human DNA Evolution
Hamidi, H.; Alinejad-Rokny, H.; Coorens, T.; Sanghvi, R.; Lindsay, S. J.; Rahbari, R.; Ebrahimi, D.
10.1101/2021.01.09.426041 — evolutionary biology — Posted on 2021-01-09
3112 Transmission of one predicts another: Apathogenic proxies for transmission dynamics of a fatal virus
Gilbertson, M. L. J.; Fountain-Jones, N. M.; Malmberg, J. L.; Gagne, R. B.; Lee, J. S.; Kraberger, S.; Kechejian, S.; Petch, R.; Chiu, E.; Onorato, D.; Cunningham, M. W.; Crooks, K. R.; Funk, W. C.; Carver, S.; VandeWoude, S.; VanderWaal, K.; Craft, M. E.
10.1101/2021.01.09.426055 — ecology — Posted on 2021-01-09
3113 Unveiling unexpected complexity and multipotentiality of early heart fields
Zhang, Q.; Carlin, D.; Zhu, F.; Cattaneo, P.; Ideker, T.; Evans, S.; Bloomekatz, J.; Chi, N. C.
10.1101/2021.01.08.425950 — developmental biology — Posted on 2021-01-09
3114 The Application of Countercurrent Chromatography for the study of Bacteriophages
Friedersdorff, J. C.; Bright, C.; Rooke, D.; Creevey, C. J.; Kingston Smith, A. H.
10.1101/2021.01.08.425911 — microbiology — Posted on 2021-01-09
3118 Endogenous Retroviral Elements Generate Pathologic Neutrophils and Elastase Rich Exosomes in Pulmonary Arterial Hypertension
Taylor, S.; Contrepois, K.; Benayoun, B.; Jiang, L. A.; Isobe, S.; Wang, L.; Melemenidis, S.; Ozen, M. O.; Otsuki, S.; Shinohara, T.; Sweatt, A. J.; Kaplan, J.; Cao, A.; Moonen, J.-R.; Marciano, D. P.; Gu, M.; Miyagawa, K.; Del Rosario, P. A.; Hsi, A.; Thompson, R.; Ariza, M.-E.; Demirci, U.; Zamanian, R. T.; Haddad, F.; Nicolls, M. R.; Snyder, M. P.; Rabinovitch, M.
10.1101/2021.01.08.426001 — immunology — Posted on 2021-01-09
3119 Double stranded RNA drives innate immune responses, sickness behavior and cognitive impairment dependent on dsRNA length, IFNAR1 expression and age
McGarry, N.; Murray, C.; Garvey, S.; Wilkinson, A.; Tortorelli, L.; Ryan, L.; Hayden, L.; Healy, D.; Griffin, E. W.; Hennessy, E.; Skelly, D. T.; Arumugam, M.; Mitchell, K. J.; Cunningham, C.
10.1101/2021.01.09.426034 — neuroscience — Posted on 2021-01-09
3121 Differential regulation of progranulin derived granulin peptides
Zhang, T.; Du, H.; Nunez Santos, M.; Wu, X.; Reinheckel, T.; Hu, F.
10.1101/2021.01.08.425959 — neuroscience — Posted on 2021-01-09
3122 Bottom-up inputs are required for the establishment of top-down connectivity onto cortical layer 1 neurogliaform cells
Ibrahim, L. A.; Huang, S.; Otero, M. F.; Sherer, M.; Vemuri, S.; Xu, Q.; Machold, R.; Rudy, B.; Fishell, G.
10.1101/2021.01.08.425944 — neuroscience — Posted on 2021-01-09
3123 Eye tracking impairments in children with protein-energy malnutrition
Almeida, N. L.; Silva, J. B. S.; Silva, N. P.; Fernandes, T. P.; Santos, N. A.
10.1101/2021.01.08.425941 — neuroscience — Posted on 2021-01-09
3127 Dependency of LKB1-inactivated lung cancer on aberrant CRTC-CREB activation
Zhou, X.; Li, J. W.; Chen, Z.; Ni, W.; Li, X.; Yang, R.; Shen, H.; Liu, J.; DeMayo, F. J.; Lu, J.; Kaye, F. J.; Wu, L.
10.1101/2021.01.09.425982 — cancer biology — Posted on 2021-01-09
3128 Targeting EGFR in glioblastoma with a novel brain-penetrant small molecule EGFR-TKI
Ni, J.; Wang, Y.; Wang, Q.; Bergholz, J. S.; Jiang, T.; Roberts, T. M.; Gray, N. S.; Zhao, J. J.
10.1101/2021.01.09.426030 — cancer biology — Posted on 2021-01-09
3132 Understanding the holobiont: crosstalk between gut microbiota and mitochondria during endurance
Mach, N.; Moroldo, M.; Rau, A.; Lecardonnel, J.; Moyec, L. L.; Robert, C.; Barrey, E.
10.1101/2021.01.08.425889 — systems biology — Posted on 2021-01-09
3133 The role of water mobility in protein misfolding
Stephens, A. D.; Kolbel, J.; Moons, R.; Ruggerio, M. T.; Mahmoudi, N.; Shmool, T. A.; McCoy, T. M.; Nietlispach, D.; Routh, A. F.; Sobott, F.; Zeitler, J. A.; Kaminski Schierle, G. S.
10.1101/2021.01.06.425575 — biophysics — Posted on 2021-01-09
3134 Structural and mechanistic insight into spectral tuning in flavin-binding fluorescent proteins
Roellen, K.; Granzin, J.; Remeeva, A.; Davari, M. D.; Gensch, T.; Nazarenko, V. V.; Kovalev, K.; Bogorodskiy, A.; Borshchevskiy, V.; Hemmer, S.; Schwaneberg, U.; Gordeliy, V.; Jaeger, K.-E.; Batra-Safferling, R.; Gushchin, I.; Krauss, U.
10.1101/2021.01.08.425906 — biophysics — Posted on 2021-01-09
3135 Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders
Wilmes, S.; Jeffrey, P.-A.; Martinez-Fabregas, J.; Hafer, M.; Fyfe, P. K.; Pohler, E.; Gaggero, S.; Lythe, G.; Launay, D.; Mitra, S.; Piehler, J.; Molina-Paris, C.; Moraga Gonzalez, I.
10.1101/2021.01.08.425379 — bioinformatics — Posted on 2021-01-09
3137 Sex and origin-specific inbreeding effects on flower attractiveness to specialised pollinators
Schrieber, K.; Paul, S. C.; Höche, L. V.; Salas, A. C.; Didszun, R.; Mössnang, J.; Müller, C.; Erfmeier, A.; Eilers, E.
10.1101/2021.01.08.425842 — ecology — Posted on 2021-01-09
3138 The repertoire of testicular extracellular vesicles cargoes and their involvement in inter-compartmental communication required for spermatogenesis
Choy, K. H. K.; Chan, S. Y.; Lam, W.; Jin, J.; Zheng, T.; Yu, S. S.; Wang, W.; Li, L.; Xie, G.; Yim, H. C. H.; Chen, H.; FOK, E. K. L.
10.1101/2021.01.08.426002 — cell biology — Posted on 2021-01-09
3139 Surveillance of Shiga toxin-producing Escherichia coli associated bloody diarrhea in Argentina
Rivas, M.; Pichel, M.; Colonna, M.; Lopez Casanello, A.; Alconcher, L.; Galavotti, J.; Prinicipi, I.; Perez Araujo, S.; Ramirez, F. B.; Gonzalez, G.; Pianciola, L.; Mazzeo, M.; Suarez, A.; Oderiz, S.; Ghezzi, L. F.; Arrigo, D. J.; Paladini, J. H.; Baroni, M. R.; Perez, S.; Tamborini, A.; Chinen, I.; Miliwebsky, E. S.; Goldbaum, F.; Munoz, L.; Spatz, L.; Sanguineti, S.; TEAM, E.
10.1101/2021.01.07.425824 — microbiology — Posted on 2021-01-09
3142 Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons
Cathala, L.; Biane, C.; Rückerl, F.; DiGregorio, D.; Shigemoto, R.; Abrahamsson, T.; Saint-Cloment, C.; Mariani, J.; Sherrard, R. M.
10.1101/2021.01.06.425658 — neuroscience — Posted on 2021-01-09
3144 VPS13D bridges the ER to Miro containing membranes
Guillen-Samander, A.; Leonzino, M.; Hanna, M. G.; Tang, N.; Shen, H.; De Camilli, P.
10.1101/2020.10.07.328906 — cell biology — Posted on 2021-01-09
3148 Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics
Wong, D. R.; Conrad, J.; Johnson, N.; Ayers, J. I.; Laeremans, A.; Lee, J. C.; Lee, J.; Prusiner, S. B.; Bandyopadhyay, S.; Butte, A. J.; Paras, N. A.; Keiser, M. J.
10.1101/2021.01.08.425973 — pharmacology and toxicology — Posted on 2021-01-09
3150 iRGD-liposomes enhance tumor delivery and therapeutic efficacy of antisense oligonucleotide drugs against primary prostate cancer and bone metastasis
Guan, J.; Guo, H.; Tang, T.; Wang, Y.; Wei, Y.; Seth, P.; Li, Y.; Dehm, S. M.; Sailor, M. J.; Ruoslahti, E.; Pang, H.-B.
10.1101/2021.01.08.426005 — cancer biology — Posted on 2021-01-09
3151 Beyond coral-algal regimes: high taxonomic resolution surveys and trait-based analyses reveal multiple benthic regimes
Reverter, M.; Jackson, M.; Rohde, S.; Moeller, M.; Bara, R.; Lasut, M. T.; Segre Reinach, M.; Schupp, P. J.
10.1101/2021.01.08.425940 — ecology — Posted on 2021-01-09
3152 REPEATED INJURY PROMOTES TRACHEOBRONCHIAL TISSUE STEM CELL ATTRITION
Ghosh, M.; Hill, C.; Alsudayri, A.; Lallier, S.; Hayes, D.; Wijeratne, S.; Mahoney, J. E.; Reynolds, S. D.
10.1101/2021.01.08.425956 — cell biology — Posted on 2021-01-09
3153 GSDMD Deficiency Protects Against Aortic Rupture
Ye, D.; Howatt, D.; Li, Z.; Daugherty, A.; Lu, H. S.; Wu, C.
10.1101/2021.01.08.425983 — molecular biology — Posted on 2021-01-09
3155 A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4A1
Li, W.; Hang, S.; Fang, Y.; Bae, S.; Zhang, Y.; Wang, G.; McCurry, M. D.; Bae, M.; Franzosa, E. A.; Huttenhower, C.; Yao, L.; Devlin, A. S.; Huh, J. R.
10.1101/2021.01.08.425963 — immunology — Posted on 2021-01-09
3158 Proton-gated coincidence detection is a common feature of GPCR signaling
Kapolka, N. J.; Rowe, J. B.; Taghon, G. J.; Morgan, W. M.; O'Shea, C. R.; Isom, D. G.
10.1101/2021.01.08.425945 — pharmacology and toxicology — Posted on 2021-01-09
3159 Pin Electrode Reactor: A novel cold atmospheric plasma device and its potential in glioblastoma treatment
deCarvalho, A. M.; Behan, S.; Scally, L.; Sarangapani, C.; Malone, R.; Cullen, P.; Tiwari, B.; Curtin, J. F.
10.1101/2021.01.08.425903 — cancer biology — Posted on 2021-01-09
3161 In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography
Ghassabi, Z.; Kuranov, R.; Wu, M.; Tayebi, B. T.; Wang, Y.; Rubinoff, I.; Liu, X.; Wollstein, G.; Schuman, J. S.; Zhang, H. F.; Ishikawa, H.
10.1101/2021.01.08.425925 — bioengineering — Posted on 2021-01-09
3162 Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy
Chang, C.; Shi, X.; Jensen, L.; Yokom, A. L.; Fracchiolla, D.; Martens, S.; Hurley, J. H.
10.1101/2021.01.08.425958 — biochemistry — Posted on 2021-01-09
3164 Does land use matter? Carbon consequences of alternative land use futures in New England
MacLean, M. G.; Duveneck, M.; Plisinski, J.; Morreale, L.; Laflower, D.; Thompson, J.
10.1101/2021.01.08.425951 — ecology — Posted on 2021-01-09
3166 Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis
Park, S.; Matte-Martone, C.; Gonzalez, D. G.; Lathrop, E. A.; May, D. P.; Pineda, C. M.; Moore, J. L.; Boucher, J. D.; Marsh, E. D.; Schmitter, A.; Cockburn, K.; Bellaiche, Y.; Greco, V.
10.1101/2021.01.08.425932 — cell biology — Posted on 2021-01-09
3167 Shear-Mediated Platelet Activation is Accompanied by Unique Alterations of Platelet Lipid Profile
Sweedo, A.; Wise, L. M.; Roka-Moiia, Y.; Teran Arce, F.; Saavedra, S. S.; Sheriff, J.; Bluestein, D.; Slepian, M. J.; Purdy, J. G.
10.1101/2021.01.08.425446 — cell biology — Posted on 2021-01-09
3168 Gut microbiome features are associated with sepsis onset and outcomes
Rao, K.; Patel, A.; Seekatz, A. M.; Bassis, C.; Sun, Y.; Henig, O.; Albin, O.; SantaLucia, J.; Woods, R.; Bachman, M. A.
10.1101/2021.01.08.426011 — microbiology — Posted on 2021-01-09
3169 Controlled spatial organization of bacterial clusters reveals cell filamentation is vital for Xylella fastidiosa biofilm formation
Anbumani, S.; da Silva, A. M.; Fischer, E. R.; de Souza e Silva, M.; von Zuben, A. A. G.; Carvahlo, H. F.; de Souza, A. A.; Janissen, R.; Cotta, M. A.
10.1101/2021.01.08.425936 — microbiology — Posted on 2021-01-09
3171 Targeting the artemisinin resistant malaria by repositioning of the anti-Hepatitis C Virus drug Alisporivir
Chaurasiya, A.; Garg, S.; Anam, Z. e.; Kumari, G.; Joshi, N.; Kumari, J.; Singhal, J.; Singh, N.; Kaushik, S.; Kaur, A.; Dubey, n.; Srivastava, P.; Marothia, M.; Kumar, M.; Das, G.; Bhattacharjee, S.; Singh, S.; Ranganathan, A.
10.1101/2021.01.08.426017 — microbiology — Posted on 2021-01-09
3172 The effect of root exudates on the transcriptome of rhizosphere Pseudomonas spp.
Mavrodi, O. V.; McWilliams, J. R.; Peter, J. O.; Berim, A.; Hassan, K. A.; Elbourne, L. D.; LeTourneau, M. K.; Gang, D. R.; Paulsen, I. T.; Weller, D. M.; Thomashow, L. S.; Flynt, A. S.; Mavrodi, D.
10.1101/2021.01.08.425997 — microbiology — Posted on 2021-01-09
3173 Local Shifts in Inflammatory and Resolving Lipid Mediators in Response to Tendon Overuse
Markworth, J. F.; Sugg, K. B.; Sarver, D. C.; Maddipati, K. R.; Brooks, S. V.
10.1101/2021.01.08.425901 — immunology — Posted on 2021-01-09
3174 Human gut bacteria produce TH17-modulating bile acid metabolites
Paik, D.; Yao, L.; Zhang, Y.; Bae, S.; D'Agostino, G. D.; Kim, E.; Franzosa, E. A.; Avila-Pacheco, J.; Bisanz, J. E.; Rakowski, C. K.; Vlamakis, H.; Xavier, R. J.; Turnbaugh, P. J.; Longman, R. S.; Krout, M. R.; Clish, C. B.; Huttenhower, C.; Huh, J. R.; Devlin, A. S.
10.1101/2021.01.08.425913 — immunology — Posted on 2021-01-09
3175 Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons
Kelley, C.; Dura-Bernal, S.; Neymotin, S. A.; Antic, S. D.; Carnevale, N. T.; Migliore, M.; Lytton, W. W.
10.1101/2021.01.08.425962 — neuroscience — Posted on 2021-01-09
3176 Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation
Theofilas, P.; Wang, C.; Butler, D.; Morales, D. O.; Petersen, C.; Chin, B.; Yang, T.; Khan, S.; Ng, R.; Kayed, R.; Karch, C. M.; Miller, B. L.; Gestwicki, J. E.; Gan, L.; Temple, S.; Arkin, M. R.; Grinberg, L. T.
10.1101/2021.01.08.425912 — neuroscience — Posted on 2021-01-09
3179 Anti-stress effects of the glucagon-like peptide-1 receptor agonist liraglutide in zebrafish
Bertelli, P. R.; Mocelin, R.; Marcon, M.; Sachett, A.; Gomez, R.; Rosa, A. R.; Herrmann, A. P.; Piato, A.
10.1101/2021.01.08.425989 — pharmacology and toxicology — Posted on 2021-01-09
3180 COMPARE, an ultra-fast and robust suite for multiparametric screening, identifies phenotypic drug responses in acute myeloid leukemia
Chalabi Hajkarim, M.; Karjalainen, E.; Osipovitch, M.; Dimopoulos, K.; Gordon, S. L.; Ambri, F.; Rasmussen, K. D.; Gronbaek, K.; Helin, K.; Wennerberg, K.; Won, K. J.
10.1101/2021.01.08.425880 — cancer biology — Posted on 2021-01-09
3186 eQTL Catalogue: a compendium of uniformly processed human gene expression and splicing QTLs
Kerimov, N.; Hayhurst, J. D.; Peikova, K.; Manning, J. R.; Walter, P.; Kolberg, L.; Samovica, M.; Pandian Sakthivel, M.; Kuzmin, I.; Trevanion, S. J.; Burdett, T.; Jupp, S.; Parkinson, H.; Papatheodorou, I.; Yates, A.; Zerbino, D. R.; Alasoo, K.
10.1101/2020.01.29.924266 — genomics — Posted on 2021-01-09
3188 ConVarT: a search engine for orthologous variants and functional inference of human genetic variants
Pir, M. S.; Bilgin, H. I.; Sayici, A.; Coskun, F.; Torun, F. M.; Zhao, P.; Kang, Y.; Cevik, S.; Kaplan, O. I.
10.1101/2021.01.07.424951 — genetics — Posted on 2021-01-09
3190 Genetic modulation of initial sensitivity to Δ9-tetrahydrocannabinol (THC) among the BXD family of mice
Parks, C.; Rogers, C. M.; Prins, J. P.; Williams, R. W.; Chen, H.; Jones, B. C.; Moore, B. M.; Mulligan, M. K.
10.1101/2021.01.08.425948 — genetics — Posted on 2021-01-09
3192 CRY2 missense mutations suppress P53 and enhance cell growth
Chan, A. B.; Parico, G. C. G.; Fribourgh, J. L.; Ibrahim, L. H.; Bollong, M. J.; Partch, C. L.; Lamia, K. A.
10.1101/2021.01.08.425994 — cell biology — Posted on 2021-01-09
3193 Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
Guo, Y.; Chomiak, A. A.; Hong, Y.; Lowe, C. C.; Chan, W.-C.; Andrade, J.; Pan, H.; Zhou, X.; Berezovski, E.; Monuki, E. S.; Feng, Y.
10.1101/2020.10.22.341784 — neuroscience — Posted on 2021-01-09
3196 Evaluating the transcriptional fidelity of cancer models
Peng, D.; Gleyzer, R.; Tai, W.-H.; Kumar, P.; Bian, Q.; Issacs, B.; Lummertz da Rocha, E.; Cai, S.; DiNapoli, K.; Huang, F.; Cahan, P.
10.1101/2020.03.27.012757 — cancer biology — Posted on 2021-01-09
3198 Widespread introgression across a phylogeny of 155 Drosophila genomes
Suvorov, A.; Kim, B. Y.; Wang, J.; Armstrong, E. E.; Peede, D.; D'Agostino, E. R. R.; Price, D. K.; Wadell, P.; Lang, M.; Courtier-Orgogozo, V.; David, J. R.; Petrov, D.; Matute, D. R.; Schrider, D. R.; Comeault, A. A.
10.1101/2020.12.14.422758 — evolutionary biology — Posted on 2021-01-09
3200 HLF Expression Defines the Human Hematopoietic Stem Cell State
Lehnertz, B.; Chagraoui, J.; MacRae, T.; Tomellini, E.; Corneau, S.; Mayotte, N.; Boivin, I.; Sauvageau, G.
10.1101/2020.06.29.177709 — developmental biology — Posted on 2021-01-08
3202 Distinct roles for dopamine clearance mechanisms in regulating behavioral flexibility
Korn, C.; Akam, T.; Jensen, K. H. R.; Vagnoni, C.; Huber, A.; Tunbridge, E. M.; Walton, M. E.
10.1101/823401 — neuroscience — Posted on 2021-01-08
3203 How we pay attention in naturalistic settings
Turoman, N.; Tivadar, R.; Retsa, C.; Murray, M. M.; Matusz, P. J.
10.1101/2020.07.30.229617 — neuroscience — Posted on 2021-01-08
3204 A Hilbert-based method for processing respiratory timeseries
Harrison, S. J.; Bianchi, S.; Heinzle, J.; Stephan, K. E.; Iglesias, S.; Kasper, L.
10.1101/2020.09.30.321562 — neuroscience — Posted on 2021-01-08
3208 Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors
Mavrommatis, L.; Jeong, H.-W.; Gomez-Giro, G.; Stehling, M.; Kienitz, M.-C.; Psathaki, O. E.; Bixel, G.; Morosan-Puopolo, G.; Gerovska, D.; Arauzo-Bravo, M. J.; Schwamborn, J. C.; Scholer, H. R.; Adams, R. H.; Vorgerd, M.; Brand-Saberi, B.; Zaehres, H.
10.1101/2020.09.14.295832 — bioengineering — Posted on 2021-01-08
3209 Transposable element landscape changes are buffered by RNA silencing in aging Drosophila
Yang, N.; Srivastav, S. P.; Rahman, R.; Ma, Q.; Dayama, G.; Chinen, M.; Lei, E. P.; Rosbash, M.; Lau, N. C.
10.1101/2021.01.08.425853 — genomics — Posted on 2021-01-08
3210 A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle
Lee, Y.-L.; Takeda, H.; Costa Monteiro Moreira, G.; Karim, L.; Mullaart, E.; Coppieters, W.; Appeltant, R.; Veerkamp, R.; Groenen, M.; Georges, M.; Bosse, M.; Druet, T.; Bouwman, A.; Charlier, C.
10.1101/2021.01.08.425854 — genomics — Posted on 2021-01-08
3211 Distinguishing gene flow between malaria parasite populations
Brown, T. S.; Taylor, A. R.; Arogbokun, O.; Buckee, C. O.; Chang, H.-H.
10.1101/2021.01.08.425858 — genomics — Posted on 2021-01-08
3214 High-quality SNPs from genic regions highlight introgression patterns among European white oaks (Quercus petraea and Q. robur).
Lang, T.; Abadie, P.; Leger, V.; Decourcelle, T.; Frigerio, J.-M.; Burban, C.; Bodenes, C.; Guichoux, E.; Le Provost, G.; Robin, C.; Tani, N.; Leger, P.; Lepoittevin, C.; El Mujtar, V. A.; Hubert, F.; Tibbits, J.; Paiva, J.; Franc, A.; Raspail, F.; Mariette, S.; Reviron, M.-P.; Plomion, C.; Kremer, A.; Desprez-Loustau, M.-L.; Garnier-Gere, P.
10.1101/388447 — evolutionary biology — Posted on 2021-01-08
3215 Choosing optimal trigger points for ex situ, in toto conservation of single population threatened species
Brown, K.; Tambyah, T.; Fenwick, J.; Burke, A.; Grant, P.; Hegarty-Cremer, S.; Muller, J.; Bode, M.
10.1101/2021.01.08.425867 — ecology — Posted on 2021-01-08
3217 Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis
Rashidieh, B.; Shohayeb, B.; Bain, A. L.; Fortuna, P. R. J.; Sinha, D.; Burgess, A.; Mills, R.; Adams, R. C.; Lopez, J. A.; Blumbergs, P.; Finnie, J.; Kalimutho, M.; Piper, M.; Hudson, J. E.; Ng, D.; Khanna, K. k.
10.1101/2021.01.08.425857 — cell biology — Posted on 2021-01-08
3218 Liver X Receptor; Controls Hepatic Stellate Cell Activation via Hedgehog Signaling
Zhong, L.; Ning, B.; Du, X.; Shengjie, H.; Cai, C.; Zhou, Y.; Deng, L.; Shen, W.
10.1101/577833 — cell biology — Posted on 2021-01-08
3224 DeepHBV: A deep learning model to predict hepatitis B virus (HBV) integration sites.
Wu, C.; Guo, X.; Li, M.; Fu, X.; Hou, Z.; Zhai, M.; Shen, J.; Qiu, X.; Cui, Z.; Xie, H.; Qin, P.; Weng, X.; Hu, Z.; Liang, J.
10.1101/2021.01.08.425855 — bioinformatics — Posted on 2021-01-08
3228 CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking
Middelkoop, T. C.; Garcia-Baucells, J.; Quintero-Cadena, P.; Pimpale, L. G.; Yazdi, S.; Sternberg, P.; Gross, P.; Grill, S. W.
10.1101/2021.01.08.425924 — developmental biology — Posted on 2021-01-08
3229 Aurora kinase A is essential for meiosis in mouse oocytes
Blengini, C. S.; Ibrahimian, P.; Vaskovicova, M.; Drutovic, D.; Solc, P.; Schindler, K.
10.1101/2021.01.08.425851 — cell biology — Posted on 2021-01-08
3230 Systematically quantifying morphological features reveals constraints on organoid phenotypes
Beck, L. E.; Lee, J.; Cote, C.; Dunagin, M. C.; Salla, N.; Chang, M. K.; Hughes, A. J.; Mornin, J. D.; Gartner, Z. J.; Raj, A.
10.1101/2021.01.08.425947 — systems biology — Posted on 2021-01-08
3231 Dicer promotes genome stability via the bromodomain transcriptional co-activator Brd4.
Gutbrod, M.; Roche, B.; Steinberg, J.; Lakhani, A.; Chang, K.; Schorn, A.; Martienssen, R. A.
10.1101/2021.01.08.425946 — genetics — Posted on 2021-01-08
3233 Genome-scale sequencing and analysis of human, wolf and bison DNA from 25,000 year-old sediment
Gelabert, P.; Sawyer, S.; Bergstrom, A.; Collin, T. C.; Meshvelian, T.; Belfer-Cohen, A.; Lordkipanidze, D.; Jakeli, N.; Matskevich, Z.; Bar-Oz, G.; Fernandes, D. M.; Cheronet, O.; Ozdogan, K. T.; Oberreiter, V.; Feeney, R. N. M.; Skoglund, P.; Pinhasi, R.
10.1101/2021.01.08.425895 — developmental biology — Posted on 2021-01-08
3234 Cysteine is a limiting factor for glioma proliferation and survival
Larion, M.; Ruiz-Rodado, V.; Dowdy, T.; Lita, A.; Kramp, T.; Zhang, M.; Jung, J.; Dios-Esponera, A.; Herold-Mende, C. C.; Camphausen, K.; Gilbert, M. R.
10.1101/2021.01.08.425930 — cancer biology — Posted on 2021-01-08
3237 Ad26.COV2.S-elicited immunity protects against G614 spike variant SARS-CoV-2 infection in Syrian hamsters and does not enhance respiratory disease in challenged animals with breakthrough infection after sub-optimal vaccine dosing
van der Lubbe, J. E. M.; Rosendahl Huber, S. K.; Vijayan, A.; Dekking, L.; van Huizen, E.; Vreugdenhil, J.; Choi, Y.; Baert, M. R. M.; Feddes-de Boer, K.; Izquierdo Gil, A.; van Heerden, M.; Dalebout, T. J.; Myeni, S. K.; Kikkert, M.; Snijder, E. J.; de Waal, L.; Stittelaar, K. J.; Tolboom, J. T. B. M.; Serroyen, J.; Muchene, L.; van der Fits, L.; Rutten, L.; Langedijk, J. P. M.; Barouch, D. H.; Schuitemaker, H.; Zahn, R. C.; Wegmann, F.
10.1101/2021.01.08.425915 — immunology — Posted on 2021-01-08
3240 Loss of PIKfyve drives the spongiform degeneration in prion diseases
Lakkaraju, A. K.; Frontzek, K.; Lemes, E.; Herrmann, U.; Losa, M.; Marpakwar, R.; Aguzzi, A.
10.1101/2021.01.08.425896 — neuroscience — Posted on 2021-01-08
3241 Genetic influences on brain activation and large-scale functional connectivity during nociceptive processing: a twin study
Kastrati, G.; Rosen, J.; Thompson, W. H.; Chen, X.; Larsson, H.; Nichols, T. E.; Tracey, I.; Fransson, P.; Ahs, F.; Jensen, K.
10.1101/2021.01.08.425878 — neuroscience — Posted on 2021-01-08
3242 Somatic mutations in CTCF zinc fingers produce cellular phenotypes explained by structure-function relationships
Rasko, J. E.; Bailey, C. G.; Gupta, S.; Metierre, C.; Amarasekera, P.; O'Young, P.; Kyaw, W.; Laletin, T.; Francis, H.; Semaan, C.; Singh, K.; Mullighan, C.; Wolkenhauer, O.; Schmitz, U.
10.1101/2021.01.08.425848 — cancer biology — Posted on 2021-01-08
3245 Measuring arterial pulsatility with Dynamic Inflow MAgnitude Contrast (DIMAC)
Whittaker, J. R.; Fasano, F.; Venzi, M.; Liebig, P.; Gallichan, D.; Murphy, K.
10.1101/2021.01.08.425882 — bioengineering — Posted on 2021-01-08
3246 Prime editing enables precise genome editing in mouse liver and retina
Jang, H.; Shin, J. H.; Jo, D. H.; Seo, J. H.; Yu, G.; Gopalappa, R.; Cho, S.-R.; Kim, J. H.; Kim, H. H.
10.1101/2021.01.08.425835 — bioengineering — Posted on 2021-01-08
3255 Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity
Sidorenko, E.; Sokolova, M.; Pennanen, A.; Kyheroinen, S.; Posern, G.; Foisner, R.; Vartiainen, M.
10.1101/2021.01.08.425886 — cell biology — Posted on 2021-01-08
3256 Clr4SUV39H1 and Bdf2BRD4 ubiquitination mediate transcriptional silencing via heterochromatic phase transitions
Kim, H.-S.; Roche, B.; Bhattacharjee, S.; Todeschini, L.; Chang, A.-Y.; Hammell, C.; Verdel, A.; Martienssen, R. A.
10.1101/2021.01.08.425919 — molecular biology — Posted on 2021-01-08
3257 Artemisia annua L. extracts prevent in vitro replication of SARS-CoV-2
Nair, M. S.; Huang, Y.; Fidock, D. A.; Polyak, S. J.; Wagoner, J.; Towler, M.; Weathers, P.
10.1101/2021.01.08.425825 — microbiology — Posted on 2021-01-08
3260 An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytes
van der Donk, L. E.; van der Spek, J.; van Duivenvoorde, T.; ten Brink, M. S.; Geijtenbeek, T. B.; Kuijl, C. P.; van Heijst, J. W.; Ates, L. S.
10.1101/2021.01.08.425881 — immunology — Posted on 2021-01-08
3262 Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy.
Shukla, R.; Henkel, N. D.; Smail, M. A.; Wu, X.; Enright, H. A.; Fischer, N.; Eby, H. M.; Carney, P. R.; McCullumsmith, R. E.
10.1101/2021.01.08.425892 — systems biology — Posted on 2021-01-08
3263 Strong and tunable anti-CRISPR/Cas9 activity of AcrIIA4 in plants
Calvache, C.; Vazquez-Vilar, M.; Selma, S.; Uranga, M.; Daros, J. A.; Orzaez, D.
10.1101/2021.01.08.425920 — synthetic biology — Posted on 2021-01-08
3264 HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
Takahashi, S.; Kanai, A.; Okuda, H.; Miyamoto, R.; Kawamura, T.; Matsui, H.; Inaba, T.; Takaori-Kondo, A.; Yokoyama, A.
10.1101/2021.01.08.425834 — cancer biology — Posted on 2021-01-08
3265 Vimentin binds to SARS-CoV-2 spike protein and antibodies targeting extracellular vimentin block in vitro uptake of SARS-CoV-2 virus-like particles
Suprewicz, L.; Swoger, M.; Gupta, S.; Piktel, E.; Byfield, F. F.; Iwamoto, D. V.; Germann, D. A.; Reszec, J.; Marcinczyk, N.; Janmey, P. A.; Schwarz, J. M.; Bucki, R.; Patteson, A. E.
10.1101/2021.01.08.425793 — biophysics — Posted on 2021-01-08
3267 UCsim2: 2D Structured Illumination Microscopy using UC2
Wang, H.; Lachmann, R.; Marsikova, B.; Heinzmann, R.; Diederich, B.
10.1101/2021.01.08.425840 — cell biology — Posted on 2021-01-08
3269 Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila
Eastwood, E. L.; Jara, K. A.; Bornelöv, S.; Munafo, M.; Frantzis, V.; Kneuss, E.; Barbar, E. J.; Czech, B.; Hannon, G. J.
10.1101/2021.01.08.425839 — molecular biology — Posted on 2021-01-08
3272 Creating wounds in cell monolayers using micro-jets
Soitu, C.; Panea, M.; Castrejon-Pita, A. A.; Cook, P. R.; Walsh, E.
10.1101/2021.01.07.425744 — bioengineering — Posted on 2021-01-08
3273 SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor
Zahradnik, J.; Marciano, S.; Shemesh, M.; Zoler, E.; Chiaravalli, J.; Meyer, B.; Dym, O.; Elad, N.; Schreiber, G.
10.1101/2021.01.06.425392 — biochemistry — Posted on 2021-01-08
3276 Is Palmer's elm leaf goldenrod real? The Angiosperms353 kit provides within-species signal in Solidago ulmifolia s.l.
Beck, J. B.; Markley, M. L.; Zielke, M. G.; Thomas, J. R.; Hale, H. J.; Williams, L. D.; Johnson, M. G.
10.1101/2021.01.07.425781 — evolutionary biology — Posted on 2021-01-08
3278 Telomerase Prevents Emphysema in Old Mice by Sustaining Subpopulations of Endothelial and AT2 Cells
BREAU, M.; CAYROU, C.; CHURIKOV, D.; FOUILLADE, C.; CURRAS ALONSO, S.; BAUWENS, S.; JOURQUIN, F.; BRAUD, L.; FIORE, F.; CATELLANO, R.; JOSSELIN, E.; SANCHEZ-FERRER, C.; GIOVINAZZO, G.; GILSON, E.; FLORES, I.; LONDONO-VALLEJO, A.; ADNOT, S.; GELI, V.
10.1101/2021.01.07.425708 — molecular biology — Posted on 2021-01-08
3281 Targeted capture and sequencing of Orientia tsutsugamushi genomes from chiggers and humans
Elliott, I.; Thangnimitchok, N.; de Cesare, M.; Linsuwanon, P.; Paris, D. H.; Day, N. P. J.; Newton, P. N.; Bowden, R.; Batty, E. M.
10.1101/2021.01.07.425812 — microbiology — Posted on 2021-01-08
3282 SARS-CoV-2 Spike Glycoprotein and ACE2 interaction reveals modulation of viral entry in wild and domestic animals
Praharaj, M. R.; Garg, P.; Kesarwani, V.; Topno, N. A.; Khan, R. I. N.; Sharma, S.; Panigrahi, M.; Mishra, B. P.; Mishra, B.; Kumar, G. S.; Gandham, R. K.; Singh, R. K.; Majumdar, S.; Mohapatra, T.
10.1101/2020.05.08.084327 — microbiology — Posted on 2021-01-08
3286 Commercial vaccines do not confer protection against two genetic strains of Piscirickettsia salmonis, LF-89-like and EM-90-like, in Atlantic salmon.
Figueroa, C.; Torrealba, D.; Morales-Lange, B.; Mercado, L.; Dixon, B.; Conejeros, P.; Silva, G.; Soto, C.; Gallardo, J. A.
10.1101/2021.01.07.424493 — immunology — Posted on 2021-01-08
3287 The impact of COVID-19 vaccination campaigns accounting for antibody-dependent enhancement
Adil M. Y., N.; Tsoungui Obama, H. C. J.; Ngucho Yvan Mbeutchou, J.; Kwamou Ngaha, S. F.; Kayanula, L.; Kamanga, G.; Ibrahim, T. B.; Bwanu Iliya, P.; Iyanda, S. B.; Alawam Nemer, L. H. M.; Helle, K. B.; Teboh-Ewungkem, M. I.; Schneider, K. A.
10.1101/2021.01.04.425198 — immunology — Posted on 2021-01-08
3288 The landscape of antibody binding in SARS-CoV-2 infection
Heffron, A. S.; McIlwain, S. J.; Amjadi, M. F.; Baker, D. A.; Khullar, S.; Sethi, A. K.; Palmenberg, A. C.; Shelef, M. A.; O'Connor, D. H.; Ong, I. M.
10.1101/2020.10.10.334292 — immunology — Posted on 2021-01-08
3289 Heart rate variability predicts decline in sensorimotor rhythm control
Nann, M.; Haslacher, D.; Colucci, A.; Eskofier, B.; von Tscharner, V.; Soekadar, S. R.
10.1101/2021.01.08.424840 — neuroscience — Posted on 2021-01-08
3290 Differential encoding of safe and risky offers
Maisson, D. J.-N.; Yoo, S. B. M.; Wang, M. Z.; Cash-Padgett, T. V.; Zimmermann, J.; Hayden, B.
10.1101/2021.01.07.425153 — neuroscience — Posted on 2021-01-08
3291 Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN
Nogami, M.; Ishikawa, M.; Doi, A.; Sano, O.; Sone, T.; Akiyama, T.; Aoki, M.; Nakanishi, A.; Ogi, K.; Yano, M.; Okano, H.
10.1101/2021.01.07.425798 — neuroscience — Posted on 2021-01-08
3293 A role for prefoldins in H2A.Z deposition in Arabidopsis
Mari-Carmona, C.; Forment, J.; Blazquez, M. A.; Alabadi, D.
10.1101/2021.01.07.425797 — plant biology — Posted on 2021-01-08
3294 Synthetic Promoter Designs Enabled by a Comprehensive Analysis of Plant Core Promoters
Jores, T.; Tonnies, J.; Wrightsman, T.; Buckler, E. S.; Cuperus, J.; Fields, S.; Queitsch, C.
10.1101/2021.01.07.425784 — plant biology — Posted on 2021-01-08
3297 IRGM/Irgm1 Aggravates Progression of Atherosclerosis by Inducing Macrophage Apoptosis
Fang, S.; Sun, S.; Cai, H.; Hao, X.; Zou, X.; Wan, X.; Tian, J.; Li, Z.; Wang, S.; He, Z.; Huang, W.; Liang, C.; Zhang, Z.; Yang, L.; Tian, J.; Yu, B.; Sun, B.
10.1101/2021.01.06.425662 — pathology — Posted on 2021-01-08
3298 GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy
Mukha, A.; Kahya, U.; Linge, A.; Chen, O.; Lock, S.; Lukiyanchuk, V.; Richter, S.; Alves, T. C.; Peitzsch, M.; Telychko, V.; Skvortsov, S.; Negro, G.; Aschenbrenner, B.; Skvortsova, I.-I.; Mirtschink, P.; Lohaus, F.; Holscher, T.; Neubauer, H.; Rivandi, M.; Franken, A.; Behrens, B.; Stoecklein, N. H.; Toma, M.; Sommer, U.; Zschaeck, S.; Rehm, M.; Eisenhofer, G.; Schwager, C.; Abdollahi, A.; Groeben, C.; Kunz-Schughart, L. A.; Baretton, G. B.; Baumann, M.; Krause, M.; Peitzsch, C.; Dubrovska, A.
10.1101/2021.01.07.425771 — cancer biology — Posted on 2021-01-08
3299 Cancer phylogenetics using single-cell RNA-seq data
Moravec, J. C.; Lanfear, R.; Spector, D.; Diermeier, S.; Gavryushkin, A.
10.1101/2021.01.07.425804 — cancer biology — Posted on 2021-01-08
3305 Z4-11Al mediates olfactory attraction and courtship in Drosophila melanogaster
Borrero-Echeverry, F.; Solum, M.; Trona, F.; Wallin, E. A.; Bengtsson, M.; Witzgall, P.; Lebreton, S.
10.1101/2021.01.06.425638 — animal behavior and cognition — Posted on 2021-01-08
3314 Transcriptomics provides a genetic signature of vineyard site with insight into vintage-independent regional wine characteristics
Reiter, T.; Montpetit, R.; Byer, S.; Frias, I.; Leon, E.; Viano, R.; Mcloughlin, M.; Halligan, T.; Hernandez, D.; Figueroa-Balderas, R.; Cantu, D.; Steenwerth, K.; Runnebaum, R.; Montpetit, B.
10.1101/2021.01.07.425830 — microbiology — Posted on 2021-01-08
3316 Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma
Choe, J. H.; Watchmaker, P. B.; Simic, M. S.; Gilbert, R. D.; Li, A. W.; Krasnow, N. A.; Carrera, D. A.; Yu, W.; Downey, K. M.; Celli, A.; Cho, J.; Briones, J. D.; Dannenfelser, R.; Cardarelli, L.; Sidhu, S. S.; Roybal, K. T.; Okada, H.; Lim, W. A.
10.1101/2021.01.07.425632 — immunology — Posted on 2021-01-08
3320 High-fidelity fast volumetric brain MRI using a hybrid denoising generative adversarial network (HDnGAN)
Li, Z.; Tian, Q.; Ngamsombat, C.; Cartmell, S.; Conklin, J.; Filho, A. L. M. G.; Lo, W.-C.; Wang, G.; Ying, K.; Setsompop, K.; Fan, Q.; Bilgic, B.; Cauley, S.; Huang, S.
10.1101/2021.01.07.425779 — neuroscience — Posted on 2021-01-08
3321 A single- and paired-pulse TMS-EEG investigation of the N100 and long interval cortical inhibition in autism spectrum disorder
Kirkovski, M.; Hill, A. T.; Rogasch, N. C.; Saeki, T.; Fitzgibbon, B. M.; Yang, J.; Do, M.; Donaldson, P. H.; Albein-Urios, N.; Fitzgerald, P. B.; Enticott, P. G.
10.1101/2021.01.06.425653 — neuroscience — Posted on 2021-01-08
3325 Disrupted PDZ-domain binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis and reward motivation
Sorensen, G.; Rickhag, M.; Leo, D.; Lycas, M. D.; Ridderstrom, P. H.; Weikop, P.; Herborg, F. H.; Woldbye, D. P.; Wortwein, G.; Gainetdinov, R. R.; Fink-Jensen, A.; Gether, U.
10.1101/2021.01.06.425643 — neuroscience — Posted on 2021-01-08
3328 Using dual-calibrated functional MRI to map brain oxygen supply and consumption in multiple sclerosis
Chandler, H. L.; Stickland, R. C.; Germuska, M.; Patitucci, E.; Foster, C.; Bhome-Dhaliwal, S.; Lancaster, T. M.; Saxena, N.; Khot, S.; Tomassini, V.; Wise, R. G.
10.1101/2021.01.07.425819 — neuroscience — Posted on 2021-01-08
3331 The renal inflammatory network of nephronophthisis.
Quatredeniers, M.; Bienaime, F.; Ferri, G.; Isnard, P.; Poree, E.; Billot, K.; Birgy, E.; Ceccarelli, S.; Legendre, F.; Braeg, S.; Nguyen-Khoa, T.; Salomon, R.; Gubler, M.-C.; Kuehn, E. W.; Saunier, S.; Viau, A.
10.1101/2021.01.07.425719 — physiology — Posted on 2021-01-08
3332 Microwell array-based opto-electrochemical detections revealing co-adaptation of rheological properties and oxygen metabolism in budding yeast
Vajrala, V. S.; Alric, B.; Laborde, A.; Colin, C.; Suraniti, E.; Temple-Boyer, P.; Arbault, S.; Delarue, M.; Launay, J.
10.1101/2021.01.07.425712 — biophysics — Posted on 2021-01-08
3335 A mammalian methylation array for profiling methylation levels at conserved sequences
Arneson, A.; Haghani, A.; Thompson, M. J.; Pellegrini, M.; Kwon, S. B.; Vu, H. T.; Li, C. Z.; Lu, A. T.; Barnes, B.; Hansen, K. D.; Zhou, W.; Breeze, C.; Ernst, J.; Horvath, S.
10.1101/2021.01.07.425637 — bioinformatics — Posted on 2021-01-08
3337 Compartmentalized three-dimensional human neuromuscular tissue models fabricated on a well-plate-format microdevice
Yamamoto, K.; Yamaoka, N.; Imaizumi, Y.; Nagashima, T.; Furutani, T.; Ito, T.; Okada, Y.; Honda, H.; Shimizu, K.
10.1101/2021.01.07.424253 — bioengineering — Posted on 2021-01-08
3339 Transcriptomic profiles of Plasmodium falciparum and Plasmodium vivax-infected individuals in Indonesia
Bobowik, K. S.; Syafruddin, D.; Crenna Darusallam, C.; Sudoyo, H.; Wells, C. A.; Gallego Romero, I.
10.1101/2021.01.07.425684 — genomics — Posted on 2021-01-08
3340 Barth syndrome cellular models have dysregulated respiratory chain complex I and mitochondrial quality control due to abnormal cardiolipin
Franca Anzmann, A.; Sniezek, O.; Pado, A.; Busa, V. F.; Vaz, F. M.; Kreimer, S.; Cole, N. R.; Le, A.; Kirsch, B.; Claypool, S. M.; Vernon, H.
10.1101/2021.01.06.425502 — genetics — Posted on 2021-01-08
3341 The impact of PNPLA3 and TM6SF2 in cirrhosis related complications
Uojima, H.; Shao, X.; Arai, T.; ogawa, Y.; Setsu, T.; Atsukawa, M.; Furuichi, Y.; Arase, Y.; Horio, K.; Hidaka, H.; Nakazawa, T.; Kako, M.; Kagawa, T.; Iwakiri, K.; Nakajima, A.; Terai, S.; Tanaka, Y.; Koizumi, W.
10.1101/2021.01.07.425655 — genetics — Posted on 2021-01-08
3343 The molecular principles of Piwi-mediated co-transcriptional silencing through the dimeric SFiNX complex
Schnabl, J.; Wang, J.; Hohmann, U.; Gehre, M.; Batki, J.; Andreev, V. I.; Purkhauser, K.; Fasching, N.; Duchek, P.; Novatchkova, M.; Mechtler, K.; Plaschka, C.; Patel, D. J.; Brennecke, J.
10.1101/2021.01.08.425619 — molecular biology — Posted on 2021-01-08
3344 Role of T cells in intrauterine administration of activated peripheral blood mononuclear cells in recurrent implantation failure.
Ricaud, G.; Vaillancourt, C.; Blais, V.; Disdier, M.; Joao, F.; Johnson, B.; Benkhalifa, M.; Miron, P.; Bernier, J.
10.1101/2021.01.06.425452 — immunology — Posted on 2021-01-08
3345 Macrophage depletion impairs neonatal tendon regeneration
Howell, K. L.; Kaji, D. A.; Montero, A.; Yeoh, K.; Nasser, P.; Huang, A. H. H.
10.1101/2021.01.07.425735 — immunology — Posted on 2021-01-08
3346 Neural correlates of orbital telorism
Pawlak, M. A.; Knol, M. J.; Vernoiij, M. W.; Ikram, M. A.; Adams, H.; Evans, T. E.
10.1101/2021.01.07.425611 — neuroscience — Posted on 2021-01-08
3348 Structural Brain Correlates of Creative Personality
Sadana, D.; Gupta, R. K.; Kumaran, S. S.; Jain, S.; Rajeswaran, J.
10.1101/2021.01.06.425561 — neuroscience — Posted on 2021-01-08
3349 Optogenetic activation of Gq signaling in astrocytes yields stimulation-specific effects on basal hippocampal synaptic excitation and inhibition
Courtney, C. D.; Sobieski, C.; Ramakrishnan, C.; Ingram, R. J.; Wojnowski, N. M.; DeFazio, R. A.; Deisseroth, K.; Christian-Hinman, C. A.
10.1101/2021.01.06.425606 — neuroscience — Posted on 2021-01-08
3353 Multiomics Integration Elucidates Metabolic Modulators of Drug Resistance in Lymphoma
Choueiry, F.; Singh, S.; Sun, X.; Zhang, S.; Sircar, A.; Hart, A.; Alinari, L.; Epperla, N.; Baiocchi, R.; Zhu, J.; Sehgal, L.
10.1101/2021.01.07.425721 — cancer biology — Posted on 2021-01-08
3354 Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia
Ding, Y.-Y.; Kim, H.; Madden, K.; Loftus, J. P.; Chen, G. M.; Allen, D. H.; Zhang, R.; Xu, J.; Hu, Y.; Tasian, S. K.; Tan, K.
10.1101/2021.01.06.425608 — cancer biology — Posted on 2021-01-08
3355 Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identity
Thirant, C.; Peltier, A.; Durand, S.; Kramdi, A.; Louis-Brennetot, C.; Pierre-Eugene, C.; Costa, A.; Grelier, A.; Zaidi, S.; Gruel, N.; Jimenez, I.; Lapouble, E.; Pierron, G.; Brisse, H.; Gauthier, A.; Freneaux, P.; Grossetete-Lalami, S.; Baudrin, L. G.; Raynal, V.; Baulande, S.; Bellini, A.; Bhalshankar, J.; Carcaboso, A. M.; Geoerger, B.; Surdez, D.; Rohrer, H.; Boeva, V.; Schleiermacher, G.; Delattre, O.; Janoueix-Lerosey, I.
10.1101/2021.01.07.425710 — cancer biology — Posted on 2021-01-08
3356 Mapping cellular subpopulations within triple negative breast cancer tumors provides a tool for cancer sensitization to radiotherapy
Alkhatib, H.; Rubinstein, A. M.; Vasudevan, S.; Flashner-Abramson, E.; Stefansky, S.; Oguche, S.; Peretz-Yablonsky, T.; Granit, A.; Granot, Z.; Ben-Porath, I.; Sheva, K.; Meirovitz, A.; Kravchenko-Balasha, N.
10.1101/2021.01.07.425553 — cancer biology — Posted on 2021-01-08
3357 Single cell proteomics of tumor compartments identifies differential kinase activities defining sensitivity to mTOR-PI3-kinase inhibition
Karabacak, N. M.; Zheng, Y.; Dubash, T. D.; Burr, R.; Micalizzi, D. S.; Wittner, B. S.; Wiley, D. F.; Comaills, V.; Emmons, E.; Niederhoffer, K.; Ho, U.; Nieman, L.; Haas, W.; Stott, S. L.; Ting, D. T.; Miyamoto, D. T.; Haber, D. A.; Toner, M.; Maheswaran, S.
10.1101/2021.01.06.425147 — cancer biology — Posted on 2021-01-08
3361 Myeloperoxidase-induced fibrinogen unfolding and clotting
Barinov, N. A.; Pavlova, E. R.; Tolstova, A. P.; Dubrovin, E. V.; Klinov, D. V.
10.1101/2021.01.06.425586 — biophysics — Posted on 2021-01-08
3366 Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition
Yosaatmadja, Y.; Baddock, H. T.; Newman, J. A.; Bielinski, M.; Gavard, A. E.; Mukhopadhyay, S. M. M.; Dannerfjord, A. A.; Schofield, C. J.; McHugh, P. J.; Gileadi, O.
10.1101/2021.01.08.423993 — biochemistry — Posted on 2021-01-08
3368 ConVarT: a search tool for orthologous variants: A method and server for functional inference of human genetic variants
Pir, M. S.; Bilgin, H. I.; Sayici, A.; Coskun, F.; Torun, F. M.; Zhao, P.; Kang, Y.; Cevik, S.; Kaplan, O. I.
10.1101/2021.01.07.424951 — genetics — Posted on 2021-01-08
3371 In vivo deciduous dental eruption in LuiKotale bonobos and Gombe chimpanzees
Lee, S. M.; Sutherland, L. J.; Fruth, B.; Murray, C. M.; Lonsdorf, E. V.; Arbenz-Smith, K.; Augusto, R.; Brogan, S.; Canington, S. L.; Lee, K. C.; McGrath, K.; McFarlin, S. C.; Hohmann, G.
10.1101/2021.01.06.425588 — evolutionary biology — Posted on 2021-01-08
3372 Using genomic prediction to detect microevolutionary change of a quantitative trait
Hunter, D. C.; Ashraf, B.; Berenos, C.; Johnston, S. E.; Wilson, A. J.; Pilkington, J. G.; Pemberton, J. M.; Slate, J.
10.1101/2021.01.06.425564 — evolutionary biology — Posted on 2021-01-08
3377 Wide distribution of alternatively coded Lak megaphages in animal microbiomes
Crisci, M. A.; Chen, L.-X.; Devoto, A. E.; Borges, A. L.; Bordin, N.; Sachdeva, R.; Tett, A.; Sharrar, A. M.; Segata, N.; Debenedetti, F.; Bailey, M.; Burt, R.; Wood, R. M.; Rowden, L. J.; Corsini, P. M.; Holmes, M. A.; Lei, S.; Banfield, J. F.; Santini, J. M.
10.1101/2021.01.08.425732 — microbiology — Posted on 2021-01-08
3378 An awareness-dependent saliency map in the human visual system
WANG, L.; HUANG, L.; LI, M.; WANG, X.; WANG, S.; LIN, Y.; ZHANG, X.
10.1101/2021.01.07.424631 — neuroscience — Posted on 2021-01-08
3379 Social Reactivation of Fear Engrams Enhances Recall and Reinstatement
Finkelstein, A. B.; Leblanc, H.; Cole, R.; Gallerani, T.; Vieira, A.; Zaki, Y.; Ramirez, S.
10.1101/2021.01.07.425728 — neuroscience — Posted on 2021-01-08
3380 Immature olfactory sensory neurons provide behaviorally useful sensory input to the olfactory bulb
Huang, J. S.; Kunkhyen, T.; Liu, B.; Muggleton, R. J.; Avon, J. T.; Cheetham, C. E. J.
10.1101/2021.01.06.425578 — neuroscience — Posted on 2021-01-08
3385 Frog nest foam as a drug delivery system
Brozio, S.; O Shaughnessy, E. M.; Woods, S.; Hall-Barrientos, I.; Martin, P. E.; Kennedy, M. W.; Lamprou, D.; Hoskisson, P. A.
10.1101/2021.01.06.425559 — bioengineering — Posted on 2021-01-08
3387 Engineering the thermotolerant industrial yeast Kluyveromyces marxianus for anaerobic growth
Dekker, W. J. C.; Ortiz-Merino, R.; Kaljouw, A.; Wiering, F. W.; Mooiman, C.; de la Torre, P.; Pronk, J. T.
10.1101/2021.01.07.425723 — biochemistry — Posted on 2021-01-08
3390 Comprehensive multi-omics study of the molecular perturbations induced by simulated diabetes on coronary artery endothelial cells
Moreno-Ulloa, A.; Delgado De la Herran, H. C.; Alvarez Delgado, C.; Mendoza Porras, O.; Carballo Castaneda, R. A.; Villarreal, F.
10.1101/2021.01.06.425584 — biochemistry — Posted on 2021-01-08
3391 A high content lipidomics method using scheduled MRM with variable retention time window and relative dwell time weightage
Bhaskar, A. K.; Naushin, S.; Ray, A.; Pradhan, S.; Adlakha, K.; Siddiqua, T. J.; Malakar, D.; Sengupta, S.
10.1101/2021.01.08.425875 — biochemistry — Posted on 2021-01-08
3392 Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrPSc
Lakkaraju, A. K.; Sorce, S.; Senatore, A.; Nuvolone, M.; Guo, J.; Schwarz, P.; Moos, R.; Pelczar, P.; Aguzzi, A.
10.1101/2021.01.03.425136 — neuroscience — Posted on 2021-01-08
3394 Genome evolution in bacteria isolated from million-year-old subseafloor sediments
Orsi, W. D.; Magritsch, T.; Vargas, S.; Coskun, O. K.; Vuillemin, A.; Hohna, S.; Worheide, G.; D'Hondt, S.; Shapiro, B. J.; Carini, P.
10.1101/2020.12.19.423498 — microbiology — Posted on 2021-01-08
3395 Sensitizing Staphylococcus aureus to antibacterial host defense by decoding and blocking the lipid flippase MprF
Slavetinsky, C. J.; Hauser, J. N.; Gekeler, C.; Slavetinsky, J.; Geyer, A.; Kraus, A.; Heilingbrunner, D.; Wagner, S.; Tesar, M.; Krismer, B.; Kuhn, S.; Ernst, C. M.; Peschel, A.
10.1101/2020.11.12.379776 — microbiology — Posted on 2021-01-08
3396 Social groups with diverse personalities mitigate physiological stress in a songbird
Vagasi, C. I.; Fulop, A.; Osvath, G.; Pap, P. L.; Penzes, J.; Benko, Z.; Lendvai, A. Z.; Barta, Z.
10.1101/2020.04.15.043471 — evolutionary biology — Posted on 2021-01-08
3397 SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4
Onodi, F.; Bonnet-Madin, L.; Meertens, L.; Karpf, L.; Poirot, J.; Zhang, S.-Y.; picard, c.; Puel, A.; Jouanguy, E.; Zhang, Q.; LeGoff, J.; Molina, J.-M.; Delaugerre, C.; Casanova, J.-L.; AMARA, A.; Soumelis, V.
10.1101/2020.07.10.197343 — immunology — Posted on 2021-01-08
3401 The Genetics and Evolution of Eye Color in Domestic Pigeons (Columba livia)
Si, S.; Xu, X.; Zhuang, Y.; Gao, X.; Zhang, H.; Zou, Z.; Luo, S.-J.
10.1101/2020.10.25.340760 — genetics — Posted on 2021-01-08
3403 KIAA0319 influences cilia length, cell migration and mechanical cell-substrate interaction
Diaz, R.; Kronenberg, N. M.; Martinelli, A.; Liehm, P.; Riches, A. C.; Gather, M. C.; Paracchini, S.
10.1101/780874 — cell biology — Posted on 2021-01-08
3405 Functionnectome: a framework to analyse the contribution of brain circuits to fMRI
Nozais, V.; Forkel, S. J.; Foulon, C. J.; Petit, L.; Thiebaut de Schotten, M.
10.1101/2021.01.06.425574 — neuroscience — Posted on 2021-01-08
3410 Aquatic microbial community is partially functionally redundant: insights from an in situ reciprocal transplant experiment
Tandon, K.; Wan, M.-T.; Yang, C.-C.; Yang, S.-H.; Baatar, B.; Chiu, C.-Y.; Tsai, J.-W.; Liu, W.-C.; Ng, C. S.; Tang, S.-L.
10.1101/2020.02.01.930198 — ecology — Posted on 2021-01-07
3412 Ischemic tolerance and cardiac repair in the African spiny mouse
Koopmans, T.; van Beijnum, H.; Roovers, E. F.; Malhotra, D.; Tomasso, A.; Boeter, J.; Versteeg, D.; van Rooij, E.; Bartscherer, K.
10.1101/2021.01.07.425783 — developmental biology — Posted on 2021-01-08
3413 Extracellular Matrix Dysfunction in Sorsby Patient-Derived Retinal Pigment Epithelium
Engel, A. L.; Wang, Y.; Khuu, T.; Worrall, E.; Manson, M. A.; Knight, K.; Yanagida, A.; Qi, J. H.; Ramakrishnan, A.; Weleber, R. G.; Klein, M.; Wilson, D. J.; Anand-Apte, B.; Hurley, J. B.; Du, J. L.; Chao, J. R.
10.1101/2021.01.06.425613 — cell biology — Posted on 2021-01-07
3416 Automaticity in the reading circuitry
Joo, S. J.; Tavabi, K.; Caffara, S.; Yeatman, J. D.
10.1101/829937 — neuroscience — Posted on 2021-01-07
3417 Cellular drivers of injury response and regeneration in the adult zebrafish heart
Hu, B.; Lelek, S.; Spanjaard, B.; Guedes Simoes, M.; Aliee, H.; Schäfer, R.; Theis, F.; Panakova, D.; Junker, J. P.
10.1101/2021.01.07.425670 — systems biology — Posted on 2021-01-07
3421 Differential serotonin uptake mechanisms at the human maternal-fetal interface
Bakovic, P.; Kesic, M.; Horvaticek, M.; George, M.; Peric, M.; Cicin-Sain, L.; Desoye, G.; Wadsack, C.; Panzenboeck, U.; Stefulj, J.
10.1101/2021.01.07.425725 — cell biology — Posted on 2021-01-07
3429 Colistin resistance in Acinetobacter baumannii is driven by multiple genomic traits: Evaluating the role of ISAba1-driven eptA overexpression among Indian isolates
Vijayakumar, S.; Jacob, J. J.; Vasudevan, K.; Shankar, B. A.; Francis, M. L.; Kirubananthan, A.; Anandan, S.; Gunasekaran, K.; Walia, K.; Biswas, I.; Kaye, K. S.; Veeraraghavan, B.
10.1101/2021.01.07.425695 — microbiology — Posted on 2021-01-07
3432 The intensity of the immune response to LPS and E. coli regulates the induction of preterm labor in Rhesus Macaques
Cappelletti, M.; Presicce, P.; Ma, F.; Senthamaraikannan, P.; Miller, L.; Pellegrini, M.; Jobe, A.; Divanovic, S.; Way, S. S.; Chougnet, C.; Kallapur, S.
10.1101/2021.01.07.425700 — immunology — Posted on 2021-01-07
3437 The peripheral T cell population is associated with pneumonia severity in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus 2
Nagata, N.; Iwata-Yoshikawa, N.; Sano, K.; Ainai, A.; Shiwa, N.; Shirakura, M.; Kishida, N.; Arita, T.; Suzuki, Y.; Harada, T.; Kawai, Y.; Ami, Y.; Iida, S.; Katano, H.; Fujisaki, S.; Sekizuka, T.; Shimizu, H.; Suzuki, T.; Hasegawa, H.
10.1101/2021.01.07.425698 — pathology — Posted on 2021-01-07
3439 Genetic composition of queen conch (Lobatus gigas) population on Pedro Bank, Jamaica and its use in fisheries management
Blythe-Mallett, A. P.; Aiken, K. A.; Segura-Garcia, I.; Truelove, N. K.; Webber, M. K.; Roye, M. E.; Box, S. J.
10.1101/2021.01.07.425691 — genetics — Posted on 2021-01-07
3442 Multiple overlapping dynamic patterns of the visual sensory network in schizophrenia
Sendi, M. S. E.; Pearlson, G. D.; Mathalon, D. H.; Ford, J. M.; Preda, A.; van Erp, T. G. M.; Calhoun, V. D.
10.1101/2020.12.21.423535 — neuroscience — Posted on 2021-01-07
3444 West Nile virus detection in horses in three Brazilian states.
Azevedo Costa, E.; Giovanetti, M.; Silva Catenacci, L.; Fonseca, V.; Aburjaile, F.; Melo Campos Iani, F.; da Cunha e Silva Vieira, M. A.; Freitas Henriques, D.; Barbosa de Almeida, D.; Maldonado Coelho Guedes, M. I.; Alvares da Silva Ramos, B. S.; Solimar Goncalves Silva, A.; de Oliveira, T.; Ribeiro Leite Jardim Cavalcante, K.; Oliveira de Moura, N. F.; Pecego Martins Romano, A.; Albuquerque, C. F. C. d.; Soares Feitosa, L. C.; Martins Bayeux, J. J.; Bertoni Cavalcanti Teixeira, R.; Lisboa Lobato, O.; da Costa Silva, S.; Lourenco, J.; Alcantara, L. C. J.
10.1101/2021.01.06.425363 — genomics — Posted on 2021-01-07
3446 Defining the Caprin-1 interactome in unstressed and stressed conditions
Vu, L.; Ghosh, A.; Tran, C.; Tebung, W. A.; Sidibé, H.; Garcia-Mansfield, K.; David-Dirgo, V.; Sharma, R.; Pirrotte, P.; Bowser, R.; Vande Velde, C.
10.1101/2021.01.06.425453 — cell biology — Posted on 2021-01-07
3447 Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils
Manriquez, V.; Nivoit, P.; Urbina, T.; Echenique-Rivera, H.; Melican, K.; Flamant, P.; Schmitt, T.; Bruneval, P.; Obino, D.; Dumenil, G.
10.1101/2021.01.07.425689 — microbiology — Posted on 2021-01-07
3449 Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits
Hyrenius-Wittsten, A.; Su, Y.; Park, M.; Garcia, J. M.; Perry, N.; Montgomery, G.; Liu, B.; Roybal, K. T.
10.1101/2021.01.06.425642 — immunology — Posted on 2021-01-07
3451 Online learning for orientation estimation during translation in an insect ring attractor network
Robinson, B. S.; Norman-Tenazas, R.; Cervantes, M.; Symonette, D.; Johnson, E. C.; Joyce, J.; Rivlin, P. K.; Hwang, G.; Zhang, K.; Gray-Roncal, W. R.
10.1101/2021.01.07.425323 — neuroscience — Posted on 2021-01-07
3452 Multi-Omic Analysis Reveals Cannabidiol Disruption of Cholesterol Homeostasis in Human Cell Lines
Guard, S. E.; Chapnick, D. A.; Poss, Z. C.; Ebmeier, C. C.; Jacobsen, J.; Nemkov, T.; Ball, K. A.; Webb, K. J.; Simpson, H. L.; Coleman, S.; Bunker, E.; Ramirez, A.; Reisz, J. A.; Sievers, R.; Stowell, M. H.; D'Alessandro, A.; Liu, X.; Old, W. M.
10.1101/2020.06.03.130864 — systems biology — Posted on 2021-01-07
3453 Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
van Dorp, S.; Qiu, R.; Choi, U. B.; Wu, M. M.; Yen, M.; Kirmiz, M.; Brunger, A. T.; Lewis, R. S.
10.1101/2020.12.17.423361 — biophysics — Posted on 2021-01-07
3459 Determining pathogenicity of variants of uncertain significance and identification of a founder variant in the epilepsy-associated gene, SZT2
Calhoun, J. D.; Aziz, M. C.; Happ, H. C.; Gunti, J.; Gleason, C.; Mohamed, N.; Zeng, K.; Hiller, M.; Bryant, E.; Mithal, D.; Bellinski, I.; Kinsley, L.; Grimmel, M.; Schwaibold, E. M.; Smith-Hicks, C.; Chassevent, A.; Scala, M.; Accogli, A.; Torella, A.; Striano, P.; Capra, V.; Bird, L. M.; Ben-Sahra, I.; Ekhilevich, N.; Hershkovitz, T.; Weiss, K.; Millichap, J.; Gerard, E. E.; Carvill, G. L.
10.1101/2021.01.06.425612 — genetics — Posted on 2021-01-07
3460 eDNA in a bottleneck: obstacles to fish metabarcoding studies in megadiverse freshwater systems
Jackman, J. M.; Benvenuto, C.; Coscia, I.; Carvalho, C. O.; Ready, J. S.; Boubli, J. P.; Magnusson, W. E.; McDevitt, A.; Sales, N. G.
10.1101/2021.01.05.425493 — ecology — Posted on 2021-01-07
3463 Rapid assembly of a polar network architecture drives efficient actomyosin contractility
Costache, V.; Prigent Garcia, S.; Plancke, C.; Begnaud, S.; Li, L.; Suman, S. K.; REYMANN, A.-C.; Kim, T.; ROBIN, F. B.
10.1101/2020.12.08.406298 — cell biology — Posted on 2021-01-07
3464 BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration
Koppens, M. A.; Davis, H.; Valbuena, G. N.; Mulholland, E. J.; Nasreddin, N.; Colombe, M.; Antanaviciute, A.; Biswas, S.; Friedrich, M.; Lee, L.; Oxford IBD Cohort Investigators, ; Wang, L. M.; Koelzer, V. H.; East, J. E.; Simmons, A.; Winton, D. J.; Leedham, S. J.
10.1101/2021.01.06.425570 — cell biology — Posted on 2021-01-07
3466 Restoration of deficient DNA Repair Genes Mitigates Genome Instability and Increases Productivity of Chinese Hamster Ovary Cells
Spahn, P.; Zhang, X.; Hu, Q.; Hamaker, N.; Hefzi, H.; Li, S.; Kuo, C.-C.; Huang, Y.; Lee, J.; Ly, P.; Lee, K.; Lewis, N. E.
10.1101/2021.01.07.425558 — cell biology — Posted on 2021-01-07
3469 Landscapes and bacterial signatures of mucosa-associated intestinal microbiota in Chilean and Spanish patients with inflammatory bowel disease
Chamorro, N.; Montero, D. A.; Gallardo, P.; Farfan, M.; Contreras, M.; De la Fuente, M.; Dubois, K.; Hermoso, M. A.; Quera, R.; Pizarro-Guajardo, M.; Paredes-Sabja, D.; Ginard, D.; Rossello-Mora, R.; Vidal, R. M.
10.1101/2021.01.04.425212 — microbiology — Posted on 2021-01-07
3471 Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera
Xie, X.; Zou, J.; Fontes-Garfias, C. R.; Xia, H.; Swanson, K. A.; Cutler, M.; Cooper, D.; Menachery, V. D.; Weaver, S. D.; Dormitzer, P. R.; Shi, P.-Y.
10.1101/2021.01.07.425740 — microbiology — Posted on 2021-01-07
3473 MinION™, a portable long-read sequencer, enables rapid vaginal microbiota analysis in a clinical setting
Komiya, S.; Matsuo, Y.; Nakagawa, S.; Morimoto, Y.; Kryukov, K.; Imanishi, T.; Okada, H.; Hirota, K.
10.1101/2021.01.07.425663 — microbiology — Posted on 2021-01-07
3476 Predictors of virus prevalence and diversity across a wild bumblebee community
Pascall, D. J.; Tinsley, M. C.; Clark, B. L.; Obbard, D. J.; Wilfert, L.
10.1101/2021.01.06.425554 — microbiology — Posted on 2021-01-07
3479 Enhancing cancer targeting of γ9δ2TCR through modified NKG2D co-stimulation
Hernandez-Lopez, P.; van Diest, E.; Johanna, I.; Heijhuurs, S.; Straetemans, T.; Sebestyen, Z.; Beringer, D. X.; Kuball, J.
10.1101/2021.01.06.424553 — immunology — Posted on 2021-01-07
3480 Human B cell lineages engaged by germinal centers following influenza vaccination are measurably evolving
Hoehn, K. B.; Turner, J. S.; Miller, F. I.; Jiang, R.; Pybus, O. G.; Ellebedy, A. H.; Kleinstein, S. H.
10.1101/2021.01.06.425648 — immunology — Posted on 2021-01-07
3481 Glycogen Synthase Kinase 3 regulates the genesis of the rare displaced ganglion cell retinal subtype
Kisseleff, E.; Vigouroux, R.; Hottin, C.; Lourdel, S.; Shah, P.; Chedotal, A.; PERRON, M.; Swaroop, A.; Roger, J. E.
10.1101/2021.01.06.425300 — neuroscience — Posted on 2021-01-07
3482 White Matter Alterations in Young Children with Prenatal Alcohol Exposure
Kar, P.; Reynolds, J. E.; Grohs, M. N.; Gibbard, W. B.; McMorris, C.; Lebel, C.
10.1101/2021.01.05.425489 — neuroscience — Posted on 2021-01-07
3485 Association between breastfeeding during infancy and white matter microstructure in early childhood
Kar, P.; Reynolds, J. E.; Grohs, M. N.; Bell, R. C.; Jarman, M.; Dewey, D.; Lebel, C.
10.1101/2021.01.05.425482 — neuroscience — Posted on 2021-01-07
3487 Effect of sub-lethal prenatal endotoxemia on murine placental transport systems and lipid homeostasis
Reginatto, M. W.; Fontes, K. N.; Monteiro, V. S.; Liacone, N.; Andrade, C. B.; Gomes, H. R.; Imperio, G. E.; Bloise, F. F.; Kluck, G.; Atella, G.; Matthews, S.; Bloise, E.; Ortiga-Carvalho, T. M.
10.1101/2020.08.04.236745 — physiology — Posted on 2021-01-07
3488 Rhizoliths identified as prehistoric filing tools for fishhook production on San Nicolas Island, California
Warmlander, S.; Smith, K. N.; Vellanoweth, R. L.; Moritz, R.; Jansson, K.; Gooding, T.; Kendig, W. E.; Sholts, S. B.
10.1101/2021.01.05.425479 — paleontology — Posted on 2021-01-07
3489 A syntenin-deficient microenvironment educates AML for aggressiveness
Leblanc, R.; Fares, J.; Goubard, A.; Castellano, R.; Camoin, L.; Balzano, M.; Ghossoub, R.; Bou-Tayet, B.; Fauriat, C.; Vey, N.; Borg, J.-P.; Collette, Y.; Aurrand-Lions, M.; David, G.; Zimmermann, P.
10.1101/2021.01.06.425538 — cancer biology — Posted on 2021-01-07
3492 Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides
Pyne, A. L. B.; Noy, A.; Main, K.; Velasco-Berrelleza, V.; Piperakis, M. M.; Mitchenhall, L. A.; Cugliandolo, F. M.; Beton, J. G.; Stevenson, C. E. M.; Hoogenboom, B. W.; Bates, A. D.; Maxwell, A.; Harris, S. A.
10.1101/863423 — biophysics — Posted on 2021-01-07
3495 Molecular dynamics simulations and functional studies reveal that hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2 expressing cells
Zhang, L.; Ghosh, S. K.; Basavarajappa, S. C.; Muller-Greven, J.; Penfield, J.; Brewer, A.; Ramakrishnan, P.; Buck, M.; Weinberg, A.
10.1101/2021.01.07.425621 — biochemistry — Posted on 2021-01-07
3496 Structural Basis of KAI2 Divergence in Legume
Guercio, A. M.; Boyer, F.-D.; Rameau, C.; de Saint Germain, A.; Shabek, N.
10.1101/2021.01.06.425465 — biochemistry — Posted on 2021-01-07
3501 Hydraulic diversity stabilizes productivity in a large-scale subtropical tree biodiversity experiment
Schnabel, F.; Liu, X.; Kunz, M.; Barry, K. E.; Bongers, F. J.; Bruelheide, H.; Fichtner, A.; Härdtle, W.; Li, S.; Pfaff, C.-T.; Schmid, B.; Schwarz, J. A.; Tang, Z.; Yang, B.; Bauhus, J.; von Oheimb, G.; Ma, K.; Wirth, C.
10.1101/2021.01.06.425434 — ecology — Posted on 2021-01-07
3503 Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex
Weigt, M.; Gao, Q.; Ban, H.; He, H.; Mastrobuoni, G.; Kempa, S.; Chen, W.; Li, F.
10.1101/518936 — molecular biology — Posted on 2021-01-07
3504 CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge
Lien, C.-E.; Lin, Y.-J.; Kuo, T.-Y.; Campbell, J. D.; Traquina, P.; Lin, M.-Y.; Liu, L. T. C.; Chuang, Y.-S.; Ku, H.-Y.; Liao, C.-C.; Chen, Y.-H.; Jan, J.-T.; Sun, C.-P.; Lin, Y.-S.; Wu, P.-Y.; Wang, Y.-C.; Tao, M.-H.; Lin, Y.-L.
10.1101/2021.01.07.425674 — microbiology — Posted on 2021-01-07
3505 New targets for drug design: Importance of nsp14/nsp10 complex formation for the 3'-5' exoribonucleolytic activity on SARS-CoV-2
Saramago, M.; Barria, C.; Costa, V.; Souza, C. S.; Viegas, S. C.; Domingues, S.; Lousa, D.; Soares, C. M.; Arraiano, C. M.; Matos, R. G.
10.1101/2021.01.07.425745 — microbiology — Posted on 2021-01-07
3506 YhcB (DUF1043), a novel cell division protein conserved across gamma-proteobacteria
Mehla, J.; Liechti, G.; Morgenstern, R. M.; Caufield, J. H.; Hosseinnia, A.; Gagarinova, A.; Phanse, S.; Brockett, M.; Sakhawalkar, N.; Babu, M.; Xiao, R.; Montelione, G. T.; Vorobiev, S.; den Blaauwen, T.; Hunt, J. F.; Uetz, P.
10.1101/2020.12.31.425005 — microbiology — Posted on 2021-01-07
3508 To make or take: bacterial lipid homeostasis during infection
Adams, F. G.; Trappetti, C.; Waters, J. K.; Zang, M.; Brazel, E. B.; Paton, J. C.; Snel, M.; Eijkelkamp, B. A.
10.1101/2021.01.06.425669 — microbiology — Posted on 2021-01-07
3509 Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in hamsters
Brustolin, M.; Rodon, J.; Rodriguez de la Concepcion, M. L.; Avila-Nieto, C.; Cantero, G.; Perez, M.; Nigeer, T.; Noguera-Julian, M.; Guallar, V.; Valencia, A.; Roca, N.; Izquierdo-Useros, N.; Blanco, J.; Clotet, B.; Bensaid, A.; Carrillo, J.; Vergara-Alert, J.; Segales, J.
10.1101/2021.01.07.425729 — pathology — Posted on 2021-01-07
3510 The LEAFY floral regulator displays pioneer transcription factor properties
Lai, X.; Blanc-Mathieu, R.; GrandVuillemin, L.; Huang, Y.; Stigliani, A.; Lucas, J.; Thevenon, E.; Loue-Manifel, J.; Daher, H.; Brun-Hernandez, E.; Vachon, G.; Latrasse, D.; Benhamed, M.; Dumas, R.; Zubieta, C.; Parcy, F.
10.1101/2021.01.07.425699 — plant biology — Posted on 2021-01-07
3514 A simple Agrobacterium-mediated stable transformation technique for the hornwort model Anthoceros agrestis
Frangedakis, E.; Waller, M.; Nishiyama, T.; Tsukaya, H.; Xu, X.; Yue, Y.; Tjahjadi, M.; Gunadi, A.; Van Eck, J.; Li, F.-W.; Szovenyi, P.; Sakakibara, K.
10.1101/2021.01.07.425778 — plant biology — Posted on 2021-01-07
3515 An epigenetic switch regulates the ontogeny of AXL positive/EGFR-TKI resistant cells by modulating miR-335 expression
Sordella, R.; Pal, D.; Safaric Tepes, P.; Lindsted, T.; Ibarra, I.; Lujambio, A.; Jimenez Sabinina, V.; Senturk, S.; Miller, M.; Korimerla, N.; Huang, J.; Glassman, L.; Lee, P.; Zeltsman, D.; Hyman, K.; Esposito, M.; Hannon, G.
10.1101/2021.01.06.425631 — cancer biology — Posted on 2021-01-07
3517 Analysis and Forecasting of Global RT-PCR Primers for SARS-CoV-2
Nayar, G.; Seabolt, E.; Kunitomi, M.; Agarwal, A.; Beck, K. L.; Mukherjee, V.; Kaufman, J.
10.1101/2020.12.26.424429 — bioinformatics — Posted on 2021-01-07
3518 Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis
Reddy, H. M.; Bhattacharya, R.; Jehan, Z.; Mishra, K.; Annapurna, P.; Tiwari, S.; Praveena, N. M.; Alex, J. L.; Dhople, V. M.; Singh, L.; Sivaramakrishnan, M.; Chaturvedi, A.; Rangaraj, N.; Shiju, T. M.; Sridevi, B.; Kumar, S.; Dereddi, R. R.; Rayabandla, S.; Jesudasan, R. A.
10.1101/285429 — genomics — Posted on 2021-01-07
3521 Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites - Trichuris muris, Brugia malayi, Heligmosomoides polygyrus and Schistosoma mansoni
Partridge, F. A.; Bataille, C. J.; Forman, R.; Marriott, A. E.; Forde-Thomas, J.; Häberli, C.; Dinsdale, R. L.; O'Sullivan, J. D.; Willis, N. J.; Wynne, G. M.; Whiteland, H.; Archer, J.; Steven, A.; Turner, J. D.; Keiser, J.; Hoffmann, K. F.; Taylor, M. J.; Else, K. J.; Russell, A. J.; Sattelle, D. B.
10.1101/2020.11.17.384933 — pharmacology and toxicology — Posted on 2021-01-07
3522 Improving variant calling using population data and deep learning
Chen, N.-C.; Kolesnikov, A.; Goel, S.; Yun, T.; Chang, P.-C.; Carroll, A.
10.1101/2021.01.06.425550 — bioinformatics — Posted on 2021-01-07
3524 Verification of CRISPR editing and finding transgenic inserts by Xdrop Indirect sequence capture followed by short- and long- read sequencing
Blondal, T.; Gamba, C.; Jagd, L. M.; Su, L.; Demirov, D.; Guo, S.; Johnston, C. M.; Riising, E. M.; Wu, X.; Mikkelsen, M. J.; Szabova, L.; Mouritzen, P.
10.1101/2020.05.28.105718 — genomics — Posted on 2021-01-07
3526 Bacillus sp. RZ2MS9, a tropical PGPR, colonizes maize endophytically and alters the plant's production of volatile organic compounds both independently and when co-inoculated with Azospirillum brasilense Ab-V5
Almeida, J. R.; Bonatelli, M. L.; Batista, B. D.; Teixeira-Silva, N.; Mondin, M.; Santos, R. C.; Bento, J. M. S.; Hayashibara, C. A. A.; Azevedo, J. L.; Quecine, M. C.
10.1101/2021.01.04.425352 — molecular biology — Posted on 2021-01-07
3527 Influence of chemically and biosynthesized silver nanoparticles on in vitro viability and infectivity of Trichinella spiralis muscle larvae
dyab, a. k.; Abd-ELrahman, S. M.; Mahmoud, A. E.-s.; Elossily, N. A.; Alsharif, F. m.; Mohamed, S. M.; Abomughaid, M. M.
10.1101/2020.12.17.423206 — microbiology — Posted on 2021-01-07
3528 Modeling and Characterization of Inter-Individual Variability in CD8 T Cell Responses in Mice
Audebert, C.; Laubreton, D.; Arpin, C.; Gandrillon, O.; Marvel, J.; Crauste, F.
10.1101/671891 — immunology — Posted on 2021-01-07
3529 The structural connectome constrains fast brain dynamics
Sorrentino, P.; Seguin, C.; Rucco, R.; Liparoti, M.; Troisi Lopez, E.; Bonavita, S.; Quarantelli, M.; Sorrentino, G.; Jirsa, V.; Zalesky, A.
10.1101/2020.11.25.393017 — neuroscience — Posted on 2021-01-07
3530 Thinking ahead: prediction in context as a keystone of language in humans and machines
Goldstein, A.; Zada, Z.; Buchnik, E.; Schain, M.; Price, A.; Aubrey, B.; Nastase, S. A.; Feder, A.; Emanuel, D.; Cohen, A.; Jansen, A.; Gazula, H.; Choe, G.; Rao, A.; Kim, C.; Casto, C.; Lora, F.; Flinker, A.; Devore, S.; Doyle, W.; Dugan, P.; Friedman, D.; Hassidim, A.; Brenner, M.; Matias, Y.; Norman, K. A.; Devinsky, O.; Hasson, U.
10.1101/2020.12.02.403477 — neuroscience — Posted on 2021-01-07
3531 Complexome profiling on the lpa2 mutant reveals insights into PSII biogenesis and new PSII associated proteins
Spaniol, B.; Lang, J.; Venn, B.; Schake, L.; Sommer, F. K.; Mustas, M.; Wollman, F.-A.; Choquet, Y.; Mühlhaus, T.; Schroda, M.
10.1101/2021.01.04.425283 — plant biology — Posted on 2021-01-07
3532 Cortico-autonomic local arousals and heightened somatosensory arousability during NREM sleep of mice in neuropathic pain
Lüthi, A.; Cardis, R.; Lecci, S.; Fernandez, L. M.; Osorio-Forero, A.; Chu Sin Chung, P.; Fulda, S.; Decosterd, I.
10.1101/2021.01.04.425347 — physiology — Posted on 2021-01-07
3533 DeepStrain: A Deep Learning Workflow for the Automated Characterization of Cardiac Mechanics
Morales, M.; van den Boomen, M.; Nguyen, C.; Kalpathy-Cramer, J.; Rosen, B.; Stultz, C.; Izquierdo-Garcia, D.; Catana, C.
10.1101/2021.01.05.425266 — bioinformatics — Posted on 2021-01-07
3536 AusTraits: a curated plant trait database for the Australian flora
Falster, D. S.; Gallagher, R.; Wenk, E.; Wright, I.; Indiarto, D.; Baxter, C.; Andrew, S. C.; Lawson, J.; Allen, S.; Fuchs, A.; Adams, M. A.; Ahrens, C. W.; Alfonzetti, M.; Angevin, T.; Atkin, O. K.; Auld, T.; Baker, A.; Bean, A.; Blackman, C. J.; Bloomfield, K.; Bowman, D.; Bragg, J.; Brodribb, T. J.; Buckton, G.; Burrows, G.; Caldwell, E.; Camac, J.; Carpenter, R.; Catford, J. A.; Cawthray, G. R.; Cernusak, L. A.; Chandler, G.; Chapman, A. R.; Cheal, D.; Cheesman, A. W.; Chen, S.-C.; Choat, B.; Clinton, B.; Clode, P.; Coleman, H.; Cornwell, W. K.; Cosgrove, M.; Crisp, M.; Cross, E.; Crous, K
10.1101/2021.01.04.425314 — ecology — Posted on 2021-01-07
3538 PTEN regulates adipocyte progenitor growth, differentiation and cellular aging
Kirstein, A. S.; Kehr, S.; Nebe, M.; Lorenz, J.; Penke, M.; Breitfeld, J.; Le Duc, D.; Kovacs, P.; Stadler, P. F.; Kiess, W.; Garten, A.
10.1101/2021.01.05.425433 — cell biology — Posted on 2021-01-07
3542 The First complete Zoroastrian-Parsi Mitochondria Reference Genome: Implications of mitochondrial signatures in an endogamous, non-smoking population
Morawala-Patell, V.; Pasha, N. S.; Krishnasamy, K.; Mittal, B.; Gopalakrishnan, C.; Mugasimangalam, R.; Sharma, N.; Khanna-Gupta, A.; Bhote-Patell, P.; Rao, S. N.; Jain, R.
10.1101/2020.06.05.124891 — genomics — Posted on 2021-01-07
3543 Shape matters: the relationship between cell geometry and diversity in phytoplankton
Ryabov, A.; Kerimoglu, O.; Litchman, E.; Olenina, I.; Roselli, L.; Basset, A.; Stanca, E.; Blasius, B.
10.1101/2020.02.06.937219 — ecology — Posted on 2021-01-07
3544 Decreased homotopic interhemispheric functional connectivity in children with autism spectrum disorder
Yao, S.; Zhou, M.; Zhang, Y.; Zhou, F.; Zhang, Q.; Zhao, Z.; Jiang, X.; Xu, X.; Becker, B.; Kendrick, K. M.
10.1101/2020.11.08.373126 — neuroscience — Posted on 2021-01-07
3546 Low-disturbance Farming Regenerates Healthy Deep Soil towards Sustainable Agriculture
Deng, F.; Wang, H.; Xie, H.; Bao, X.; He, H.; Zhang, X.; Liang, C.
10.1101/828673 — ecology — Posted on 2021-01-07
3548 Neuron-type specificity of dorsal raphe projections to ventral tegmental area
Chang, A. J.; Wang, L.; Lucantonio, F.; Adams, M.; Lemire, A.; Dudman, J. T.; Cohen, J. Y.
10.1101/2021.01.06.425641 — neuroscience — Posted on 2021-01-07
3553 Metabolite discovery through global annotation of untargeted metabolomics data
Chen, L.; Lu, W.; Wang, L.; Xing, X.; Teng, X.; Zeng, X.; Muscarella, A. D.; Shen, Y.; Cowan, A. J.; McReynolds, M. R.; Kennedy, B.; Lato, A. M.; Campagna, S. R.; Singh, M.; Rabinowitz, J. D.
10.1101/2021.01.06.425569 — bioinformatics — Posted on 2021-01-06
3556 Incidence and Characteristics of Co-infection and Secondary Infection in Patients with COVID-19
Guo, Y.; Qu, J.; Cheng, L.; Li, X.; Liu, N.; Li, T.; Jiang, Y.; Wan, Q.; Zhuo, C.; Xiao, S.; Liu, B.; Chen, Y.; Fu, l.; Chen, Z.; Ma, M.; Zhuo, C.; Zhong, N.
10.1101/2021.01.06.425542 — microbiology — Posted on 2021-01-06
3559 Limited evidence for parallel evolution among desert adapted Peromyscus deer mice
Colella, J. P.; Tigano, A.; Dudchenko, O.; Omer, A. D.; Khan, R.; Bochkov, I. D.; Aiden, E. L.; MacManes, M. D.
10.1101/2020.06.29.178392 — evolutionary biology — Posted on 2021-01-06
3564 Maintenance of Complex I and respiratory super-complexes by NDUF-11 is essential for respiratory function, mitochondrial structure and health in C. elegans
Knapp-Wilson, A.; Pereira, G. C.; Buzzard, E.; Corey, R. A.; Richardson, A. P.; Neal, C.; Verkade, P.; Halestrap, A. P.; Gold, V.; Kuwabara, P.; Collinson, I.
10.1101/2021.01.06.425530 — molecular biology — Posted on 2021-01-06
3565 Genome-wide screening of circadian and non-circadian impact of Neat1 genetic deletion
Jacq, A.; Becquet, D.; Bello-Goutierrez, M.-M.; Boyer, B.; Guillen, S.; Franc, J.-L.; Francois-Bellan, A.-M.
10.1101/2021.01.06.425556 — molecular biology — Posted on 2021-01-06
3569 Predictors of virus prevalence and diversity across a wild bumblebee community
Pascall, D. J.; Tinsley, M. C.; Clark, B. L.; Obbard, D. J.; Wilfert, L.
10.1101/2021.01.06.425554 — microbiology — Posted on 2021-01-06
3571 Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compound
Hefnawy, A.; Negreira, G.; Jara, M.; Cotton, J. A.; Maes, I.; D'Haenens, E.; Imamura, H.; Cuypers, B.; Monsieurs, P.; Mouchtoglou, C.; De Winter, H.; Berriman, M.; Sanders, M.; Martin, J.; De Muylder, G.; Dujardin, J.-C.; Sterckx, Y. G.-J.; Domagalska, M. A.
10.1101/2021.01.05.425522 — microbiology — Posted on 2021-01-06
3574 Hierarchical Regulation of Autophagy During Adipocyte Differentiation
Ahmed, M.; Lai, T. H.; Pham, T. M.; Zada, S.; Elashkar, O.; Hwang, J. S.; Kim, D. R.
10.1101/2021.01.06.425505 — systems biology — Posted on 2021-01-06
3578 West Nile virus detection in horses in three Brazilian states.
Azevedo Costa, E.; Giovanetti, M.; Silva Catenacci, L.; Fonseca, V.; Aburjaile, F.; Melo Campos Iani, F.; da Cunha e Silva Vieira, M. A.; Maldonado Coelho Guedes, M. I.; Alvares da Silva Ramos, B. S.; Solimar Goncalves Silva, A.; de Oliveira, T.; Oliveira de Moura, N. F.; Pecego Martins Romano, A.; Soares Feitosa, L. C.; Martins Bayeux, J. J.; Bertoni Cavalcanti Teixeira, R.; Lisboa Lobato, O.; da Costa Silva, S.; Lourenco, J.; Alcantara, L. C. J.
10.1101/2021.01.06.425363 — genomics — Posted on 2021-01-06
3579 A suite of rare microbes interacts with a dominant, heritable, fungal endophyte to influence plant trait expression
Harrison, J.; Beltran, L. P.; Buerkle, C. A.; Cook, D.; Gardner, D.; Parchman, T. L.; Poulson, S. R.; Forister, M. L.
10.1101/608729 — ecology — Posted on 2021-01-06
3580 Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy
Wang, C.; Yang, T.; Xiao, J.; Xu, C.; Alippe, Y.; Sun, K.; Kanneganti, T.-D.; Monahan, J. B.; Abu-Amer, Y.; Lieberman, J.; Mbalaviele, G.
10.1101/2021.01.06.425634 — immunology — Posted on 2021-01-06
3581 Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration
Siddiq, M. M.; Hannila, S. S.; Zorina, Y.; Nikulina, E.; Rabinovich, V.; Hou, J.; Huq, R.; Richman, E. L.; Tolentino, R. E.; Hansen, J.; Velenosi, A.; Kwon, B. K.; Tsirka, S. E.; Maze, I.; Sebra, R.; Iyengar, R.; Filbin, M. T.
10.1101/365825 — neuroscience — Posted on 2021-01-06
3582 Whole-brain dynamics of human sensorimotor adaptation
Standage, D. I.; Areshenkoff, C. N.; Gale, D. J.; Nashed, J. Y.; Flanagan, J. R.; Gallivan, J. P.
10.1101/2020.11.27.401679 — neuroscience — Posted on 2021-01-06
3589 Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma
Risom, T.; Glass, D. R.; Liu, C. C.; Rivero-Gutierrez, B.; Baranski, A.; McCaffrey, E. F.; Greenwald, N. F.; Kagel, A. C.; Strand, S. H.; Varma, S.; Kong, A.; Keren, L.; Srivastava, S.; Zhu, C.; Khair, Z.; Veis, D. J.; Deschryver, K.; Vennam, S.; Maley, C.; Hwang, E. S.; Marks, J. R.; Bendall, S. C.; Colditz, G. A.; West, R. B.; Angelo, M.
10.1101/2021.01.05.425362 — cancer biology — Posted on 2021-01-06
3598 SARS-CoV-2 spike downregulates tetherin to enhance viral spread
Stewart, H.; Johansen, K. H.; McGovern, N.; Palmulli, R.; Carnell, G. W.; Heeney, J. L.; Okkenhaug, K.; Firth, A.; Peden, A. A.; Edgar, J. R.
10.1101/2021.01.06.425396 — cell biology — Posted on 2021-01-06
3599 Endosomal cAMP production broadly impacts the cellular phosphoproteome
Tsvetanova, N. G.; Trester-Zedlitz, M.; Newton, B. W.; Peng, G. E.; Johnson, J. R.; Jimenez-Morales, D.; Krogan, N. J.; von Zastrow, M.
10.1101/2021.01.06.425636 — cell biology — Posted on 2021-01-06
3602 Antiviral activity of bacterial TIR domains via signaling molecules that trigger cell death
Ofir, G.; Herbst, E.; Baroz, M.; Cohen, D.; Millman, A.; Doron, S.; Tal, N.; Malheiro, D. B. A.; Malitsky, S.; Amitai, G.; Sorek, R.
10.1101/2021.01.06.425286 — microbiology — Posted on 2021-01-06
3603 A mRNA-LNP vaccine against Dengue Virus elicits robust, serotype-specific immunity
Wollner, C. J.; Richner, M. C.; Hassert, M. A.; Pinto, A. K.; Brien, J. D.; Richner, J. M.
10.1101/2021.01.05.425517 — microbiology — Posted on 2021-01-06
3605 SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor
Zahradnik, J.; Marciano, S.; Shemesh, M.; Zoler, E.; Chiaravalli, J.; Meyer, B.; Dym, O.; Elad, N.; Schreiber, G.
10.1101/2021.01.06.425392 — biochemistry — Posted on 2021-01-06
3606 Zinc-embedded fabrics inactivate SARS-CoV-2 and influenza A virus
Gopal, V.; Nilsson-Payant, B. E.; French, H.; Siegers, J. Y.; Yung, W.-s.; Hardwick, M.; te Velthuis, A. J. W.
10.1101/2020.11.02.365833 — microbiology — Posted on 2021-01-06
3607 Gamma-irradiated SARS-CoV-2 vaccine candidate, OZG-38.61.3, confers protection from SARS-CoV-2 challenge in human ACEII-transgenic mice
Turan, R. D.; Tastan, C.; Dilek Kancagi, D.; Yurtsever, B.; Sir Karakus, G.; Ozer, S.; Abanuz, S.; Cakirsoy, D.; Tumentemur, G.; Demir, S.; Seyis, U.; Kuzay, R.; Elek, M.; Kocaoglu, M. E.; Ertop, G.; Arbak, S.; Acikel Elmas, M.; Hemsinlioglu, C.; Hatirnaz Ng, O.; Akyoney, S.; Sahin, I.; Kayhan, C. K.; Tokat, F.; Akpinar, G.; Kasap, M.; Kocagoz, A. S.; Ozbek, U.; Telci, D.; Sahin, F.; Yalcin, K.; Ratip, S.; Ince, U.; Ovali, E.
10.1101/2020.10.28.356667 — immunology — Posted on 2021-01-06
3609 Cocaine causes rapid remodeling of mesoaccumbens dopaminergic axons, synapses, and mitochondria
Wildenberg, G. A.; Sorokina, A. M.; Koranda, J.; Monical, A.; Heer, C.; Sheffield, M.; Zhuang, X.; McGehee, D. S.; Kasthuri, N.
10.1101/2020.09.29.318881 — neuroscience — Posted on 2021-01-06
3610 The H3K36me2 writer-reader dependency in H3K27M-DIPG
Yu, J.-R.; LeRoy, G.; Bready, D.; Frenster, J. D.; Saldana-Meyer, R.; Jin, Y.; Descostes, N.; Stafford, J. M.; Placantonakis, D. G.; Reinberg, D.
10.1101/2021.01.06.425580 — cancer biology — Posted on 2021-01-06
3611 KERA: Analysis Tool for Multi-Process, Multi-State Single-Molecule Data
Tibbs, J.; Ghoneim, M.; Caldwell, C. C.; Buzynski, T.; Bowie, W.; Boehm, E. M.; Washington, M. T.; Tabei, S. M. A.; Spies, M.
10.1101/2021.01.04.425319 — biophysics — Posted on 2021-01-06
3612 Genome Methylation Predicts Age and Longevity of Bats
Wilkinson, G. S.; Adams, D. M.; Haghani, A.; Lu, A.; Zoller, J.; Breeze, C. E.; Arnold, B. D.; Ball, H. C.; Carter, G. G.; Cooper, L. N.; Dechmann, D. K. N.; Devanna, P. S.; Fasel, N. J.; Galazyuk, A. V.; Gunther, L.; Hurme, E.; Jones, G.; Knornschild, M.; Lattenkamp, E. Z.; Li, C. Z.; Mayer, F.; Reinhardt, J. A.; Medellin, R. A.; Nagy, M.; Pope, B.; Power, M. L.; Ransome, R. D.; Teeling, E. C.; Vernes, S. C.; Zamora-Mejias, D.; Zhang, J.; Horvath, S. C.
10.1101/2020.09.04.283655 — genomics — Posted on 2021-01-06
3614 Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males
Walker, E. M.; Cha, J.; Tong, X.; Guo, M.; Liu, J.-H.; Yu, S.; Iacovazzo, D.; Mauvais-Jarvis, F. M.; Flanagan, S. E.; Korbonits, M.; Stafford, J.; Jacobson, D. A.; Stein, R.
10.1101/2020.06.29.177527 — molecular biology — Posted on 2021-01-06
3615 Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19
Kamle, S.; Ma, B.; He, C. H.; Akosman, B.; Zhou, Y.; Lee, C.-M.; El-Deiry, W. S.; Huntington, K.; Liang, O.; Machan, J. T.; Kang, M.-J.; Shin, H. J.; Mizoguchi, E.; Lee, C. G.; Elias, J. A.
10.1101/2021.01.05.425478 — immunology — Posted on 2021-01-06
3617 Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice
Borrelli, K. N.; Langan, C. R.; Dubinsky, K. R.; Szumlinski, K. K.; Carlezon, W. A.; Chartoff, E. H.; Bryant, C. D.
10.1101/2020.06.05.137190 — neuroscience — Posted on 2021-01-06
3619 Protein scaffold-based multimerization of soluble ACE2 efficiently blocks SARS-CoV-2 infection in vitro
Kayabolen, A.; Akcan, U.; Ozturan, D.; Sarayloo, E.; Nurtop, E.; Ozer, B.; Sahin, G. N.; Dogan, O.; Lack, N.; Kaya, M.; Albayrak, C.; Can, F.; Solaroglu, I.; Bagci-Onder, T.
10.1101/2021.01.04.425128 — molecular biology — Posted on 2021-01-06
3621 COVID-19 virtual patient cohort reveals immune mechanisms driving disease outcomes
Jenner, A. L.; Aogo, R. A.; Alfonso, S.; Crowe, V.; Smith, A. P.; Morel, P. A.; Davis, C. L.; Smith, A. M.; Craig, M.
10.1101/2021.01.05.425420 — immunology — Posted on 2021-01-06
3622 Adipocyte-specific deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality
GOMEZ SALAZAR, M.; PRUNONOSA CERVERA, I.; WANG, R.; FRENCH, K.; GARCIA-MARTIN, R.; BLÜHER, M.; SCHOFIELD, C. J.; STIMSON, R. H.; CHAVAKIS, T.; GUDMUNDSSON, E. F.; JENNINGS, L. L.; GUDNASON, V. G.; MORTON, N. M.; EMILSSON, V.; MICHAILIDOU, Z.
10.1101/2021.01.05.425401 — physiology — Posted on 2021-01-06
3623 The H3K36me2 writer-reader dependency in H3K27M-DIPG
Reinberg, D.; Yu, J.-R.; LeRoy, G.; Bready, D.; Frenster, J. D.; Saldana-Meyer, R.; Jin, Y.; Descostes, N.; Stafford, J. M.; Placantonakis, D. G.
10.1101/2021.01.06.425580 — cancer biology — Posted on 2021-01-06
3624 Kinetic and structural mechanism for DNA unwinding by a non-hexameric helicase
Carney, S. P.; Ma, W.; Whitley, K. D.; Jia, H.; Lohman, T. M.; Luthey-Schulten, Z. A.; Chemla, Y. R.
10.1101/2021.01.05.425498 — biophysics — Posted on 2021-01-06
3627 The skin environment controls local dendritic cell differentiation and function through innate IL-13
Mayer, J. U.; Lamiable, O.; Hilligan, K. L.; Chandler, J. S.; Old, S. I.; Eccles, D. A.; Yang, J.; Webb, G. R.; Domingues, R. G.; Munoz-Erazo, L.; Wakelin, K. A.; Hyde, E. J.; Tang, S.-C.; Chappell, S. C.; Mackay, C. R.; Brombacher, F.; Sher, A.; Tussiwand, R.; Connor, L. M.; Jankovic, D.; Hepworth, M. R.; Le Gros, G.; Ronchese, F.
10.1101/2021.01.05.425466 — immunology — Posted on 2021-01-06
3630 Misregulation of translation drives prostate cancer drug resistance
Lelong, E. I. J.; Adjibade, P.; Joncas, F.-H.; Grenier St-Sauveur, V.; Lambert, J.-P.; Toren, P.; Mazroui, R.; Hussein, S. M. I.
10.1101/2021.01.05.425492 — cancer biology — Posted on 2021-01-06
3631 Cis-Regulatory Element Hijacking by Structural Variants Overshadows Topological Changes in Primary Prostate Cancer
Hawley, J. R.; Zhou, S.; Arlidge, C.; Grillo, G.; Kron, K.; Hugh-White, R.; van der Kwast, T.; Fraser, M.; Boutros, P. C.; Bristow, R. G.; Lupien, M.
10.1101/2021.01.05.425333 — cancer biology — Posted on 2021-01-06
3634 Simultaneous readout of multiple FRET pairs using photochromism
Roebroek, T.; Vandenberg, W.; Sipieter, F.; Hugelier, S.; Stove, C.; Zhang, J.; Dedecker, P.
10.1101/2021.01.06.425528 — biophysics — Posted on 2021-01-06
3640 Cohesin-mediated loop anchors confine the location of human replication origins
Emerson, D. J.; Zhao, P. A.; Klein, K.; Ge, C.; Zhou, L.; Sasaki, T.; Yang, L.; Venvev, S. V.; Gibcus, J. H.; Dekker, J.; Gilbert, D. M.; Phillips-Cremins, J. E.
10.1101/2021.01.05.425437 — genomics — Posted on 2021-01-06
3646 Identifying low risk insecticides to address both food shortages and the biocontrol of human schistosomiasis
Haggerty, C.; Delius, B.; Jouanard, N.; Ndao, P. D.; De Leo, G. A.; Lund, A. J.; Lopez-Carr, D.; Remais, J. V.; Riveau, G.; Sokolow, S. H.; Rohr, J. R.
10.1101/2021.01.05.425425 — ecology — Posted on 2021-01-06
3647 The elevational ascent and spread of exotic annual grasslands in the Great Basin, USA
Smith, J. T.; Allred, B. W.; Boyd, C. S.; Davies, K. W.; Jones, M. O.; Maestas, J. D.; Morford, S. L.; Naugle, D. E.
10.1101/2021.01.05.425458 — ecology — Posted on 2021-01-06
3648 Neural stem cells alter nucleocytoplasmic partitioning and accumulate nuclear polyadenylated transcripts during quiescence
Rossi, A.; Coum, A.; Madelenat, M.; Harris, L.; Miedzik, A.; Strohbuecker, S.; Chai, A.; Fiaz, H.; Chaouni, R.; Faull, P.; Grey, W.; Bonnet, D.; Makeyev, E. V.; Snijders, A. P.; Kelly, G.; Guillemot, F.; Sousa-Nunes, R.
10.1101/2021.01.06.425462 — developmental biology — Posted on 2021-01-06
3650 Increased sensitivity to strong perturbations in a whole-brain model of LSD
Jobst, B. M.; Atasoy, S.; Ponce-Alvarez, A.; Sanjuan, A.; Roseman, L.; Kaelen, M.; Carhart-Harris, R.; Kringelbach, M. L.; Deco, G.
10.1101/2021.01.05.425415 — neuroscience — Posted on 2021-01-06
3655 Sugar feeding enhances gut immunity and protects against arboviral infection in the mosquito vector Aedes aegypti
Almire, F.; Terry, S.; McFarlane, M.; Szemiel, A.; Terhzaz, S.; Varjak, M.; McDonald, A.; Kohl, A.; Pondeville, E.
10.1101/2021.01.05.425375 — physiology — Posted on 2021-01-06
3658 RASSF1C oncogene elicits amoeboid invasion, cancer stemness and invasive EVs via a novel SRC/Rho axis
Tognoli, M. L.; Vlahov, N.; Steenbeek, S.; Grawenda, A. M.; Eyres, M.; Cano-Rodriguez, D.; Scrace, S.; Kartsonaki, C.; von Kriegsheim, A.; Willms, E.; Wood, M.; Rots, M. G.; van Rheenen, J.; O'Neill, E.; Pankova, D.
10.1101/2021.01.05.425393 — cancer biology — Posted on 2021-01-06
3659 Agonistic CD40 antibody therapy induces tertiary lymphoid structures but impairs the response to immune checkpoint blockade in glioma
van Hooren, L.; Vaccaro, A.; Ramachandran, M.; Vazaios, K.; Libard, S.; van de Walle, T.; Georganaki, M.; Huang, H.; Pietilä, I.; Lau, J.; Ulvmar, M. H.; Karlsson, M. C.; Zetterling, M.; Mangsbo, S. M.; Jakola, A. S.; Olsson Bontell, T.; Smits, A.; Essand, M.; Dimberg, A.
10.1101/2021.01.05.425377 — cancer biology — Posted on 2021-01-06
3665 Dietary specialisation in a Critically Endangered pipefish revealed by faecal eDNA metabarcoding
Ntshudisane, O. K.; Emami-Khoyi, A.; Gouws, G.; Weiss, S.-E.; James, N. C.; Oliver, J.-C.; Tensen, L.; Schnelle, C.; Jansen van Vuuren, B.; Bodill, T.; Cowley, P. D.; Whitfield, A.; Teske, P.
10.1101/2021.01.05.425398 — ecology — Posted on 2021-01-06
3668 Automation of Leaf Counting in Maize and Sorghum Using Deep Learning
Miao, C.; Guo, A.; Thompson, A. M.; Yang, J.; Ge, Y.; Schnable, J. C.
10.1101/2020.12.19.423626 — plant biology — Posted on 2021-01-06
3670 A novel skeletal-specific adipogenesis pathway defines key origins and adaptations of bone marrow adipocytes with age and disease
Robles, H.; Zhang, X.; Magee, K. L.; Lorenz, M. R.; Wang, Z.; Harris, C. A.; Craft, C. S.; Scheller, E. L.
10.1101/2021.01.05.425449 — cell biology — Posted on 2021-01-06
3671 Relocation of rDNA repeats for repair is dependent on SUMO-mediated nucleolar release by the Cdc48/p97 segregase
Capella, M.; Mandemaker, I. K.; Martin Caballero, L.; Pfander, B.; Ladurner, A. G.; Jentsch, S.; Braun, S. J.
10.1101/2021.01.05.425376 — molecular biology — Posted on 2021-01-06
3675 Post-Translational Modifications Soften Vimentin Intermediate Filaments
Kraxner, J.; Lorenz, C.; Menzel, J.; Parfentev, I.; Silbern, I.; Denz, M.; Urlaub, H.; Schwappach, B.; Koester, S.
10.1101/2020.06.05.135780 — biophysics — Posted on 2021-01-06
3676 Integrated cross-study datasets of genetic dependencies in cancer
Pacini, C.; Dempster, J. M.; Boyle, I.; Goncalves, E.; Najgebauer, H.; Karakoc, E.; van der Meer, D.; Barthorpe, A.; Lightfoot, H.; Jaaks, P.; McFarland, J. M.; Garnett, M.; Tsherniak, A.; Iorio, F.
10.1101/2020.05.22.110247 — bioinformatics — Posted on 2021-01-06
3682 Different translation dynamics of β- and γ-actin regulates cell migration
Vedula, P.; Kurosaka, S.; Mactaggart, B.; Ni, Q.; Papoian, G. A.; Jiang, Y.; Dong, D. W.; Kashina, A.
10.1101/2021.01.05.425467 — cell biology — Posted on 2021-01-06
3683 Functional plasticity of polarity proteins controls epithelial tissue architecture
Biehler, C.; Rothenberg, K. E.; Jette, A.; Gaude, H.-M.; Fernandez-Gonzalez, R.; Laprise, P.
10.1101/2021.01.05.425461 — cell biology — Posted on 2021-01-06
3688 Amino acids targeted based metabolomics study in non-segmental Vitiligo: a pilot study
Marzabani, R.; Rezadoost, H.; Choopanian, P.; Kolahdooz, S.; Mozafari, N.; Mirzaie, M.; Karimi, M.; Nieminen, A. I.; Jafari, M.
10.1101/2021.01.04.425209 — biochemistry — Posted on 2021-01-06
3690 Transient response of basal ganglia network in healthy and low-dopamine state
Chakravarty, K.; Roy, S.; Sinha, A.; Chiken, S.; Nambu, A.; Hellgren Kotaleski, J.; Kumar, A.
10.1101/2021.01.05.425413 — neuroscience — Posted on 2021-01-06
3692 Training level reveals a dynamic dialogue between stress and memory systems in birds
Lormant, F.; Ferreira, V. H. B.; Lemarchand, J.; Cornilleau, F.; Constantin, P.; Parias, C.; Bertin, A.; Lansade, L.; Leterrier, C.; Levy, F.; Calandreau, L.
10.1101/2021.01.05.425468 — animal behavior and cognition — Posted on 2021-01-06
3698 EMS-based mutants are useful for enhancing drought tolerance in spring wheat
Rahman, M.-u.-; Zahra, S.; Zulfiqar, S.; Hussain, M.; Akhtar, M.; Shaheen, T.
10.1101/2021.01.05.425390 — plant biology — Posted on 2021-01-05
3699 Extracellular matrix changes in colorectal carcinoma and correlation with lymph node metastasis
Theodoro, T. R.; Serrano, R. L.; Turke, K. C.; Saad, S. S.; Ribeiro Junior, M. A. F.; Waisberg, J.; Pinhal, M. A. S.
10.1101/2021.01.05.425386 — cancer biology — Posted on 2021-01-05
3703 Corticospinal correlates of hand preference for reaching during whole-body motion
Oostwoud Wijdenes, L.; Wynn, S. C.; Roesink, B. S.; Schutter, D. J. L. G.; Selen, L. P. J.; Medendorp, W. P.
10.1101/2021.01.05.425205 — neuroscience — Posted on 2021-01-05
3705 Cell motility driven by long-lived spatial memory
D'Alessandro, J.; Barbier-Chebbah, A.; Cellerin, V.; Benichou, O.; Mege, R.-M.; Voituriez, R.; Ladoux, B.
10.1101/2021.01.05.425035 — biophysics — Posted on 2021-01-05
3709 Genome Wide Association Study in the New Haven Lexinome Project Identifies GARRE1 as a Novel Gene for Reading Performance
Adams, A. K.; Guertin, E. L.; Truong, D. T.; Atkinson, E. G.; DeMille, M. M. C.; Bosson-Heenan, J. M.; Frijters, J. C.; Gruen, J. R.
10.1101/2021.01.05.423827 — genetics — Posted on 2021-01-05
3710 Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes
Gonzalez Teran, B.; Pittman, M.; Felix, F.; Richmond-Buccola, D.; Thomas, R.; Choudhary, K.; Moroni, E.; Colombo, G.; Alexanian, M.; Cole, B.; Samse-Knapp, K.; McGregor, M.; Gifford, C. A.; Huttenhain, R.; Gelb, B. D.; Conklin, B. R.; Black, B. L.; Bruneau, B. G.; Krogan, N. J.; Pollard, K. S.; Srivastava, D.
10.1101/2021.01.05.423837 — genetics — Posted on 2021-01-05
3711 Mutagenesis Mapping of RNA Structures within the Foot-and-Mouth Disease Virus Genome Reveals Functional Elements Localised in the Polymerase (3Dpol) Encoding Region.
Lasecka-Dykes, L.; Tulloch, F.; Simmonds, P.; Luke, G. A.; Ribeca, P.; Gold, S.; Knowles, N. J.; Wright, C. F.; Wadsworth, J.; Azhar, M.; King, D. P.; Tuthill, T. J.; Jackson, T.; Ryan, M. D.
10.1101/2021.01.04.425359 — evolutionary biology — Posted on 2021-01-05
3712 Plastid phylogenomics of the Sansevieria clade (Dracaena; Asparagaceae) resolves a rapid evolutionary radiation
van Kleinwee, I.; Larridon, I.; Shah, T.; Bauters, K.; Asselman, P.; Goetghebeur, P.; Leliaert, F.; Veltjen, E.
10.1101/2021.01.05.421016 — evolutionary biology — Posted on 2021-01-05
3713 Latitudinal patterns in intertidal ecosystem structure in West Greenland suggest resilience to climate change
Thyrring, J.; Wegeberg, S.; Blicher, M. E.; Krause-Jensen, D.; Høgslund, S.; Olesen, B.; Wiktor, J.; Mouritsen, K. N.; Peck, L. S.; Sejr, M. K.
10.1101/2021.01.05.419028 — ecology — Posted on 2021-01-05
3714 Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages
Domingues, N.; Calado, R. D. A.; Brito, P.; Matthiesen, R.; Ramalho, J.; Soares, M. I. L.; Pereira, T.; Oliveira, L.; Vicente, J.; Wong, L. H.; Cho, S. M.; Simoes, I.; Sampaio, J.; Klose, C.; Surma, M. A.; Almeida, M. S.; Rodrigues, G.; Goncalves, P. A.; Ferreira, J.; Simons, K.; Melo, T.; Peden, A.; Guimas Almeida, C.; Futter, C. E.; Futerman, A. H.; Vaz, W.; Vieira, O. V.
10.1101/2021.01.05.422575 — cell biology — Posted on 2021-01-05
3715 Associations between brain structure and sleep patterns across adolescent development
Jalbrzikowski, M.; Hayes, R. A.; Scully, K. E.; Franzen, P. L.; Hasler, B. P.; Siegle, G. J.; Buysse, D. J.; Dahl, R. E.; Forbes, E. E.; Ladouceur, C. D.; McMakin, D. L.; Ryan, N. D.; Silk, J. S.; Goldstein, T. R.; Soehner, A. M.
10.1101/2021.01.05.424689 — neuroscience — Posted on 2021-01-05
3720 Comberons from single cell transcriptomics in endothelial cells
Domanskyi, S.; Hakansson, A.; Meng, M.; Graff Zivin, J. S.; Piermarocchi, C.; Paternostro, G.; Ferrara, N.
10.1101/2021.01.04.425317 — systems biology — Posted on 2021-01-05
3722 POT1 Stability and Binding Measured by Fluorescence Thermal Shift Assays
DeLeeuw, L. W.; Monsen, R. C.; Petrauskas, V.; Gray, R. D.; Baranauskiene, L.; Matulis, D.; Trent, J. O.; Chaires, J.
10.1101/2021.01.01.425048 — biophysics — Posted on 2021-01-05
3724 Sample-wise unsupervised deconvolution of complex tissues
Chen, L.; Lin, C.-H.; Wu, C.-T.; Clarke, R.; Yu, G.; Van Eyk, J. E.; Herrington, D. M.; Wang, Y.
10.1101/2021.01.04.425315 — bioinformatics — Posted on 2021-01-05
3725 PreQual: An automated pipeline for integrated preprocessing and quality assurance of diffusion weighted MRI images
Cai, L. Y.; Yang, Q.; Hansen, C. B.; Nath, V.; Ramadass, K.; Johnson, G. W.; Conrad, B. N.; Boyd, B. D.; Begnoche, J. P.; Beason-Held, L. L.; Shafer, A. T.; Resnick, S. M.; Taylor, W. D.; Price, G. R.; Morgan, V. L.; Rogers, B. P.; Schilling, K. G.; Landman, B. A.
10.1101/2020.09.14.260240 — bioengineering — Posted on 2021-01-05
3727 Chromatin Fiber Folding Represses Transcription and Loop Extrusion in Quiescent Cells
Swygert, S. G.; Lin, D.; Portillo-Ledesma, S.; Lin, P.-Y.; Hunt, D. R.; Kao, C.-F.; Schlick, T.; Noble, W. S.; Tsukiyama, T.
10.1101/2020.11.24.396713 — molecular biology — Posted on 2021-01-05
3728 Genomic Background Governs Opposing Responses to Nalidixic Acid Upon Megaplasmid Acquisition in Pseudomonas
Baltrus, D. A.; Smith, C.; Derrick, M.; Leligdon, C.; Rosenthal, Z.; Mollico, M.; Moore, A.; Clark, M.
10.1101/832428 — microbiology — Posted on 2021-01-05
3729 Spontaneous selection of Cryptosporidium drug resistance in a calf model of infection
Hasan, M. M.; Stebbins, E. E.; Choy, R. K. M.; Gillespie, J. R.; de Hostos, E.; Miller, P. J.; Mushtaq, A.; Ranade, R. M.; Teixeira, J. E.; Verlinde, C. L. M. J.; Sateriale, A.; Zhang, Z.; Osbourn, D. M.; Griggs, D. W.; Fan, E.; Buckner, F. S.; Huston, C. D.
10.1101/2021.01.04.425361 — microbiology — Posted on 2021-01-05
3731 Topographical biomaterials instruct bacterial surface attachment and the in vivo host-pathogen response
Romero, M.; Luckett, J.; Figueredo, G.; Carabelli, A.; Carlier, A.; Vasilevich, A. S.; Vermeulen, S.; Scurr, D.; Hook, A.; Dubern, J.-F.; da Silva, A. C.; Winkler, D. A.; Ghaemmaghami, A. M.; de Boer, J.; Alexander, M. R.; Williams, P.
10.1101/2020.10.10.328146 — microbiology — Posted on 2021-01-05
3732 Weight loss response following lifestyle intervention associated with baseline gut metagenomic signature in humans
Diener, C.; Qin, S.; Zhou, Y.; Patwardhan, S.; Tang, L.; Lovejoy, J.; Magis, A. T.; Price, N. D.; Hood, L.; Gibbons, S. M.
10.1101/2021.01.05.425474 — microbiology — Posted on 2021-01-05
3733 IgA Potentiates NETosis in Response to Viral Infection
Stacey, H. D.; Golubeva, D.; Posca, A.; Ang, J. C.; Novakowski, K. E.; Zahoor, M. A.; Kaushic, C.; Cairns, E.; Bowdish, D.; Mullarkey, C. E.; Miller, M. S.
10.1101/2021.01.04.424830 — immunology — Posted on 2021-01-05
3734 Multi-Spatial Scale Dynamic Interactions between Functional Sources Reveal Sex-Specific Changes in Schizophrenia
Iraji, A.; Faghiri, A.; Fu, Z.; Rachakonda, S.; Kochunov, P.; Belger, A.; Ford, J.; McEwen, S.; Mathalon, D.; Mueller, B.; Pearlson, G. D.; Potkin, S. G.; Preda, A.; Turner, J.; Van Erp, T.; Calhoun, V.
10.1101/2021.01.04.425222 — neuroscience — Posted on 2021-01-05
3739 Distinct roles and actions of PDI family enzymes in catalysis of nascent-chain disulfide formation
Hirayama, C.; Machida, K.; Noi, K.; Murakawa, T.; Okumura, M.; Ogura, T.; Imataka, H.; Inaba, K.
10.1101/2021.01.04.425348 — biochemistry — Posted on 2021-01-05
3741 Spatial population genomics of a recent mosquito invasion
Schmidt, T. L.; Swan, T.; Chung, J.; Karl, S.; Demok, S.; Yang, Q.; Field, M. A.; Muzari, M. O.; Ehlers, G.; Brugh, M.; Bellwood, R.; Horne, P.; Burkot, T. R.; Ritchie, S.; Hoffmann, A. A.
10.1101/2020.11.30.405191 — genomics — Posted on 2021-01-05
3743 Behavioral and genomic sensory adaptations underlying the pest activity of Drosophila suzukii
Durkin, S. M.; Chakraborty, M.; Abrieux, A.; Lewald, K. M.; Gadau, A.; Svetec, N.; Peng, J.; Kopyto, M.; Langer, C. B.; Chiu, J. C.; Emerson, J. J.; Zhao, L.
10.1101/2020.10.15.341594 — evolutionary biology — Posted on 2021-01-05
3745 Familiar neighbours, but not relatives, enhance fitness in a territorial mammal
Siracusa, E. R.; Boutin, S.; Dantzer, B.; Lane, J. E.; Coltman, D. W.; McAdam, A. G.
10.1101/589002 — evolutionary biology — Posted on 2021-01-05
3748 Dinophyceae use exudates as weapons against the parasite Amoebophrya sp. (Syndiniales)
Long, M.; Marie, D.; Szymczak, J.; Toullec, J.; Bigeard, E.; Sourisseau, M.; Le Gac, M.; Guillou, L.; Jauzein, C.
10.1101/2021.01.05.425281 — microbiology — Posted on 2021-01-05
3751 Virus-associated organosulfur metabolism in human and environmental systems
Kieft, K.; Breister, A. M.; Huss, P.; Linz, A. M.; Zanetakos, E.; Zhou, Z.; Rahlff, J.; Esser, S. P.; Probst, A. J.; Raman, S.; Roux, S.; Anantharaman, K.
10.1101/2021.01.05.425418 — microbiology — Posted on 2021-01-05
3753 Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential drug sensitivity
Steketee, P. C.; Dickie, E. A.; Iremonger, J.; Crouch, K.; Paxton, E.; Jayaraman, S.; Alfituri, O. A.; Awuah-Mensah, G.; Ritchie, R.; Schnaufer, A.; De Koning, H.; Gadelha, C.; Wickstead, B.; Barrett, M. P.; Morrison, L. J.
10.1101/2021.01.05.425368 — microbiology — Posted on 2021-01-05
3756 A sinusoidal transform of the visual field in cortical area V2
Sedigh-Sarvestani, M.; Lee, K.-S.; Satterfield, R.; Shultz, N.; Fitzpatrick, D.
10.1101/2020.12.08.416651 — neuroscience — Posted on 2021-01-05
3757 Evidence for a deep, distributed and dynamic semantic code in human ventral anterior temporal cortex
Rogers, T. T.; Cox, C.; Lu, Q.; Shimotake, A.; Kikuch, T.; Kunieda, T.; Miyamoto, S.; Takahashi, R.; Ikeda, A.; Matsumoto, R.; Lambon Ralph, M. A.
10.1101/695049 — neuroscience — Posted on 2021-01-05
3758 Mapping the dynamic transfer functions of epigenome editing
Lee, J. B.; Caywood, L. M.; Lo, J. Y.; Levering, N. B.; Keung, A. J.
10.1101/2021.01.05.425451 — synthetic biology — Posted on 2021-01-05
3761 The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor
Legge, D.; Ling, L.; Moriarty, W.; Lee, D.; Szemes, M.; Zahed, A.; Panousopoulus, L.; Chung, W. Y.; Aghabi, Y.; Barratt, J.; Williams, R.; Pritchard-Jones, K.; Malik, K.; Oltean, S.; Brown, K. W.
10.1101/2020.11.02.364570 — cancer biology — Posted on 2021-01-05
3763 Structural basis of rotavirus RNA chaperone displacement and RNA annealing
Bravo, J. P. K.; Bartnik, K.; Venditti, L.; Gail, E. H.; Davidovich, C.; Lamb, D. C.; Tuma, R.; Calabrese, A. N.; Borodavka, A.
10.1101/2020.10.26.354233 — biophysics — Posted on 2021-01-05
3764 RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splicing variants in cancer
Cotto, K. C.; Feng, Y.-Y.; Ramu, A.; Skidmore, Z. L.; Kunisaki, J.; Richters, M.; Freshour, S.; Lin, Y.; Chapman, W.; Uppaulri, R.; Govindan, R.; Griffith, O. L.; Griffith, M.
10.1101/436634 — bioinformatics — Posted on 2021-01-05
3767 Large-scale quantification of human osteocyte lacunar morphological biomarkers as assessed by ultra-high-resolution desktop micro-computed tomography
Goff, E.; Buccino, F.; Bregoli, C.; McKinley, J. P.; Aeppli, B.; Recker, R. R.; Shane, E.; Cohen, A.; Kuhn, G.; Müller, R.
10.1101/2021.01.05.425223 — bioengineering — Posted on 2021-01-05
3769 High-throughput tandem-microwell assay for ammonia repositions FDA-Approved drugs to Helicobacter pylori infection
Liu, F.; Yu, J.; Zhang, Y.; Li, F.; Liu, Q.; Zhou, Y.; Huang, S.; Fang, H.; Xiao, Z.; Liao, L.; Xu, J.; Wu, X.-Y.; Wu, F.
10.1101/2021.01.05.425432 — biochemistry — Posted on 2021-01-05
3770 Intramolecular quality control: HIV-1 Envelope gp160 signal-peptide cleavage as a functional folding checkpoint
McCaul, N. D.; Quandte, M.; Bontjer, I.; van Zadelhoff, G.; Land, A.; Sanders, R. W.; Braakman, I.
10.1101/2020.07.08.188672 — biochemistry — Posted on 2021-01-05
3771 Distribution and diversity of dimetal-carboxylate halogenases in cyanobacteria
Eusebio, N.; Rego, A.; Glasser, N. R.; Castelo-Branco, R.; Balskus, E. P.; Leao, P. N.
10.1101/2021.01.05.425448 — biochemistry — Posted on 2021-01-05
3772 An optimized ribodepletion approach for C. elegans RNA-sequencing libraries
Barrett, A.; McWhirter, R.; Taylor, S. R.; Weinreb, A.; Miller, D.; Hammarlund, M.
10.1101/2021.01.04.425342 — genomics — Posted on 2021-01-05
3773 High-resolution QTL mapping with Diversity Outbred mice identifies genetic variants that impact gut microbiome composition
Schlamp, F.; Zhang, D. Y.; Beltran, J. F.; Cosgrove, E.; Simecek, P.; Edwards, M.; Goodrich, J. K.; Ley, R. E.; Churchill, G. A.; Clark, A. G.
10.1101/722744 — genetics — Posted on 2021-01-05
3780 Homogenization of a Reaction Diffusion Equation can Explain Influenza A Virus Load Data
Baabdulla, A. A.; Park, J. A.; Now, H.; Kim, W.-J.; Jung, S.; Yoo, J.-Y.; Hillen, T.
10.1101/2021.01.04.425332 — microbiology — Posted on 2021-01-05
3781 Proteomic interrogation of the pathogen-host interface in cholera
Zoued, A.; Zhang, H.; Zhang, T.; Giorgio, R. T.; Kuehl, C. J.; Fakoya, B.; Sit, B.; Waldor, M. K.
10.1101/2021.01.05.425471 — microbiology — Posted on 2021-01-05
3783 Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites
Stokes, B. H.; Rubiano, K.; Dhingra, S. K.; Mok, S.; Straimer, J.; Gnadig, N. F.; Bath, J. R.; Deni, I.; Ward, K. E.; Striepen, J.; Yeo, T.; Ross, L. S.; Legrand, E.; Ariey, F.; Cunningham, C. H.; Souleymane, I. M.; Gansane, A.; Nzoumbou-Boko, R.; Ndayikunda, C.; Kabanywanyi, A. M.; Uwimana, A.; Smith, S. J.; Kolley, O.; Ndounga, M.; Warsame, M.; Leang, R.; Nosten, F.; Anderson, T. J. C.; Rosenthal, P. J.; Menard, D.; Fidock, D. A.
10.1101/2021.01.05.425445 — microbiology — Posted on 2021-01-05
3784 HIV modifies the m6A and m5C epitranscriptomic landscape of the host cell
Cristinelli, S.; Angelino, P.; Janowczyk, A.; Delorenzi, M.; Ciuffi, A.
10.1101/2021.01.04.425358 — microbiology — Posted on 2021-01-05
3785 Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice
Cohen, A. A.; Gnanapragasam, P. N. P.; Lee, Y. E.; Ou, S.; Kakutani, L. M.; Keeffe, J. R.; Barnes, C. O.; Wu, H.-J.; Howarth, M.; West, A. P.; Nussenzweig, M. C.; Bjorkman, P. J.
10.1101/2020.11.17.387092 — immunology — Posted on 2021-01-05
3786 The evolution of cold nociception in drosophilid larvae and identification of a neural basis for cold acclimation
Himmel, N. J.; Letcher, J. M.; Sakurai, A.; Gray, T. R.; Benson, M. N.; Donaldson, K. J.; Cox, D. N.
10.1101/2021.01.04.425280 — neuroscience — Posted on 2021-01-05
3789 Tumor-Antagonizing Fibroblasts Secrete Prolargin as Tumor Suppressor in Hepatocellular Carcinoma
Chiavarina, B.; Ronca, R.; Otaka, Y.; Sutton, R. B.; Rezzola, S.; Yokobori, T.; Chiodelli, P.; Souche, R.; Maraver, A.; Faa, G.; Oyama, T.; Gofflot, S.; Bellahcene, A.; Detry, O.; Delvenne, P.; Castronovo, V.; Nishiyama, M.; Turtoi, A.
10.1101/2021.01.04.425182 — cancer biology — Posted on 2021-01-05
3791 debar, a sequence-by-sequence denoiser for COI-5P DNA barcode data
Nugent, C. M.; Elliott, T. A.; Ratnasingham, S.; Hebert, P. D. N.; Adamowicz, S. J.
10.1101/2021.01.04.425285 — bioinformatics — Posted on 2021-01-05
3792 Genetic epidemiology of variants associated with immune escape from global SARS-CoV-2 genomes
Jolly, B.; Rophina, M.; Shamnath, A.; Imran, M.; Bhoyar, R. C.; Divakar, M. K.; Rani, P. R.; Ranjan, G.; Sehgal, P.; Chandrasekhar, P.; Afsar, S.; Lakshmi, J. V.; Surekha, A.; Sivasubbu, S.; Scaria, V.
10.1101/2020.12.24.424332 — bioinformatics — Posted on 2021-01-05
3795 Scaling up: understanding movement from individual differences to population-level dispersal
Edelsparre, A. H.; Hefley, T.; Rodriguez, M. A.; Fitzpatrick, M. J.; Sokolowski, M. B.
10.1101/2021.01.04.425125 — ecology — Posted on 2021-01-05
3796 Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis
Ayaub, E. A.; Poli, S.; Ng, J.; Adams, T. S.; Schupp, J. C.; Quesada, L.; Poli, F.; Cosme, C.; Matthew, R.; Martinez, J.; Liang, X.; Villalba, J.; Lederer, J. A.; Chu, S. G.; Raby, B.; Washko, G.; Coarfa, C.; Perrella, M. A.; El-Chemaly, S.; Kaminski, N.; Rosas, I.
10.1101/2021.01.04.425268 — cell biology — Posted on 2021-01-05
3797 SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation
Hörnich, B. F.; Grosskopf, A. K.; Schlagowski, S.; Tenbusch, M.; Kleine-Weber, H.; Neipel, F.; Stahl-Hennig, C.; Hahn, A. S.
10.1101/2020.07.25.221135 — microbiology — Posted on 2021-01-05
3798 Rapid inactivation in vitro of SARS-CoV-2 in saliva by black tea and green tea
Ohgitani, E.; Shin-Ya, M.; Ichitani, M.; Kobayashi, M.; Takihara, T.; Kawamoto, M.; Kinugasa, H.; Mazda, O.
10.1101/2020.12.28.424533 — microbiology — Posted on 2021-01-05
3799 Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates
Zabaleta, N.; Dai, W.; Bhatt, U.; Chichester, J. A.; Estelien, R.; Sanmiguel, J.; Michalson, K. T.; Diop, C.; Maciorowski, D.; Qi, W.; Hudspeth, E.; Cucalon, A.; Dyer, C. D.; Pampena, M. B.; Knox, J. J.; LaRocque, R. C.; Charles, R. C.; Li, D.; Kim, M.; Sheridan, A.; Storm, N.; Johnson, R. I.; Feldman, J.; Hauser, B. M.; Ryan, A.; Kobayashi, D. T.; Chauhan, R.; McGlynn, M.; Ryan, E. T.; Schmidt, A. G.; Price, B.; Honko, A.; Griffiths, A.; Yaghmour, S.; Hodge, R.; Betts, M. R.; Freeman, M. W.; Wilson, J. M.; Vandenberghe, L. H.
10.1101/2021.01.05.422952 — immunology — Posted on 2021-01-05
3804 All-Flesh Tomato Regulated by Reduced Dosage of AFF Provides New Insights into Berry Fruit Evolution
Liu, L.; Zhang, K.; Bai, J.; Lu, J.; Lu, X.; Hu, J.; Pan, C.; He, S.; Yuan, J.; Zhang, Y.; Zhang, M.; Guo, Y.; Wang, X.; Huang, Z.; Du, Y.; Cheng, F.; Li, J.
10.1101/2021.01.04.425284 — plant biology — Posted on 2021-01-05
3807 FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction
Diener, J. L.; Mowbray, S.; Yowe, D.; Xu, J.; Caplan, S.; Misra, A.; Kapur, A.; Huang, W.-J.; Shapiro, J.; Ke, X.; Wu, X.; Bose, A.; Panza, D.; Chen, M.; Beaulieu, V.; Gao, J.
10.1101/2021.01.04.425295 — pharmacology and toxicology — Posted on 2021-01-05
3808 A novel universal algorithm for filament network tracing and cytoskeleton analysis
Flormann, D. A.; Schu, M.; Terriac, E.; Thalla, D.; Kainka, L.; Koch, M.; Gad, A. K.; Lautenschlaeger, F.
10.1101/2021.01.04.425230 — biophysics — Posted on 2021-01-05
3809 Mechanics of the cellular microenvironment as perceived by cells in vivo
Mongera, A.; Pochitaloff, M.; Gustafson, H. J.; Stooke-Vaughan, G. A.; Rowghanian, P.; Campas, O.
10.1101/2021.01.04.425259 — biophysics — Posted on 2021-01-05
3812 A read count-based method to detect multiplets and their cellular origins from snATAC-seq data
Thibodeau, A.; Eroglu, A.; Lawlor, N.; Nehar-Belaid, D.; Kursawe, R.; Marches, R.; Kuchel, G. A.; Banchereau, J.; Stitzel, M. L.; Cicek, A. E.; Ucar, D.
10.1101/2021.01.04.425250 — bioinformatics — Posted on 2021-01-05
3814 Metabolomic Signature of Amino Acids in Plasma of Patients with non-segmental Vitiligo
Marzabani, R.; Rezadoost, H.; Choopanian, P.; Kolahdooz, S.; Mozafari, N.; Mirzaie, M.; Karimi, M.; Nieminen, A. I.; Jafari, M.
10.1101/2021.01.04.425209 — biochemistry — Posted on 2021-01-05
3820 Reciprocal Priming between RTKs within Recycling Endosomes Orchestrates Cellular Signaling Outputs
Smith, M. P.; Ferguson, H. R.; Ferguson, J.; Zindy, E.; Kowalczyk, K. M.; Kedward, T.; Bates, C.; Parsons, J.; Watson, J.; Chandler, S.; Fullwood, P.; Warwood, S.; Knight, D.; Clarke, R. B.; Francavilla, C.
10.1101/2021.01.04.425243 — cell biology — Posted on 2021-01-05
3822 Synergistic interferon alpha-based drug combinations inhibit SARS-CoV-2 and other viral infections in vitro
Ianevski, A.; Yao, R.; Zusinaite, E.; Lello, L. S.; Wang, S.; Jo, E.; Yang, J.; Lysvand, H.; Loseth, K.; Oksenych, V.; Tenson, T.; Windisch, M. P.; Poranen, M.; Nieminen, A. I.; Nordbo, S. A.; Fenstad, M. H.; Grodeland, G.; Aukrust, P.; Troseid, M.; Kantele, A.; Merits, A.; Bjoras, M.; Kainov, D. E.
10.1101/2021.01.05.425331 — microbiology — Posted on 2021-01-05
3823 SARS-CoV-2 susceptibility of cell lines and substrates commonly used in diagnosis and isolation of influenza and other viruses
Wang, L.; Fan, X.; Bonenfant, G.; Cui, D.; Hossain, J.; Jiang, N.; Larson, G.; Currier, M.; Liddell, J.; Wilson, M.; Tamin, A.; Harcourt, J.; Ciomperlik-Patton, J.; Pang, H.; Dybdahl-Sissoko, N.; Campagnoli, R.; Shi, P.-Y.; Barnes, J. R.; Thornburg, N. J.; Wentworth, D. E.; Zhou, B.
10.1101/2021.01.04.425336 — microbiology — Posted on 2021-01-05
3825 Proton receptors regulate synapse-specific reconsolidation in the amygdala
Koffman, E. E.; Kruse, C. M.; Singh, K.; Naghavi, F. N.; Egbo, J. A.; Boateng, S.; Houdi, M. B.; Lin, B.; Debiec, J.; Du, J.
10.1101/2021.01.04.425235 — neuroscience — Posted on 2021-01-05
3828 Deletion of Serf2 shifts amyloid conformation in an Aβ amyloid mouse model
Stroo, E.; Janssen, L.; Sin, O.; Hogewerf, W.; Koster, M. H.; Harkema, L.; Youssef, S. A.; beschorner, N.; Wolters, A. H. G.; Bakker, B.; Thathiah, A.; Foijer, F.; van de Sluis, B.; van Deursen, J.; Jucker, M.; de Bruin, A.; Nollen, E.
10.1101/2021.01.05.423442 — molecular biology — Posted on 2021-01-05
3831 The adhesion capability of S. aureus cells is heterogeneously distributed over the cell envelope
Spengler, C.; Glatz, B. A.; Maikranz, E.; Bischoff, M.; Klatt, M. A.; Santen, L.; Fery, A.; Jacobs, K.
10.1101/2021.01.05.425282 — biophysics — Posted on 2021-01-05
3833 Single-molecule super-resolution imaging of T-cell plasma membrane CD4 redistribution upon HIV-1 binding
Yuan, Y.; Jacobs, C.; Llorente Garcia, I.; Pereira, P. M.; Lawrence, S.; Laine, R. F.; Marsh, M.; Henriques, R.
10.1101/2021.01.05.425371 — biophysics — Posted on 2021-01-05
3834 Disorder is a critical component of lipoprotein sorting in Gram-negative bacteria
El Rayes, J.; Szewczyk, J.; Deghelt, M.; matagne, a.; Iorga, B. I.; Cho, S.-H.; Collet, J.-F.
10.1101/2021.01.05.425367 — biochemistry — Posted on 2021-01-05
3835 Alzheimer's genetic risk effects on cerebral blood flow are spatially consistent and proximal to gene expression across the lifespan
Chandler, H. L.; Wise, R. G.; Linden, D. E.; Williams, J.; Murphy, K.; Lancaster, T. M.; Alzheimers Disease Neuroimaging Initiative (ADNI),
10.1101/2020.12.31.424949 — genetics — Posted on 2021-01-05
3836 Effects of plant community history, soil legacy and plant diversity on soil microbial communities
Schmid, M. W.; van Moorsel, S. J.; Hahl, T.; De Luca, E.; De Deyn, G.; Wagg, C.; Niklaus, P. A.; Schmid, B.
10.1101/2020.07.08.193409 — ecology — Posted on 2021-01-05
3837 Amnion signals are essential for mesoderm formation in primates
Yang, R.; Goedel, A.; Kang, Y.; Si, C.; Chu, C.; Zheng, Y.; Chen, Z.; Gruber, P. J.; Xiao, Y.; Zhou, C.; Witman, N.; Leung, C.-Y.; Chen, Y.; Fu, J.; Ji, W.; Lanner, F.; Niu, Y.; Chien, K. R.
10.1101/2020.05.28.118703 — developmental biology — Posted on 2021-01-05
3838 Quantitative profiling of native RNA modifications and their dynamics using nanopore sequencing
Begik, O.; Lucas, M. C.; Pryszcz, L. P.; Ramirez, J. M.; Medina, R.; Milenkovic, I.; Cruciani, S.; Liu, H.; Vieira, H. G. S.; Sas-Chen, A.; Mattick, J. S.; Schwartz, S.; Novoa, E. M.
10.1101/2020.07.06.189969 — molecular biology — Posted on 2021-01-05
3842 TopoStats - a program for automated tracing of biomolecules from AFM images
Beton, J. G.; Moorehead, R.; Helfmann, L.; Gray, R.; Hoogenboom, B.; Joseph, A. P.; Topf, M.; Pyne, A. L. B.
10.1101/2020.09.23.309609 — biophysics — Posted on 2021-01-05
3845 Comparing statistical and mechanistic models to identify the drivers of mortality within a rear-edge beech population
Petit-Cailleux, C.; Davi, H.; Lefevre, F.; Garrigue, J.; Magdalou, J.-A.; Hurson, C.; Magnanou, E.; Oddou-Muratorio, S.
10.1101/645747 — ecology — Posted on 2021-01-05
3846 Evidence for an Active Role of Inferior Frontal Cortex in Conscious Experience
Weilnhammer, V. A.; Fritsch, M.; Chikermane, M.; Eckert, A.-L.; Kanthak, K.; Stuke, H.; Kaminski, J.; Sterzer, P.
10.1101/2020.05.28.114645 — neuroscience — Posted on 2021-01-05
3847 Non-cell autonomous OTX2 transcription factor regulates anxiety-related behaviors in the mouse
Vincent, C.; Gilabert-Juan, J.; Gibel-Russo, R.; Alvarez-Fischer, D.; Krebs, M.-O.; Le Pen, G.; Prochiantz, A.; Di Nardo, A. A.
10.1101/710848 — neuroscience — Posted on 2021-01-05
3850 KERA: Analysis Tool for Multi-Process, Multi-State Single-Molecule Data
Tibbs, J.; Ghoneim, M.; Caldwell, C. C.; Buzynski, T.; Bowie, W.; Boehm, E. M.; Washington, M. T.; Tabei, S. M. A.; Spies, M.
10.1101/2021.01.04.425319 — biophysics — Posted on 2021-01-05
3851 Population Differentiation of Rhodobacteraceae Along Coral Compartments
Luo, H.; Luo, D.; Wang, X.; Feng, X.; Tian, M.; Wang, S.; Tang, S.-L.; Ang, P. O.; Yan, A.
10.1101/2020.12.31.424895 — microbiology — Posted on 2021-01-05
3853 Autism associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses
Bucher, M.; Niebling, S.; Han, Y.; Molodenskiy, D.; Kreienkamp, H.-J.; Svergun, D.; Kim, E.; Kostyukova, A. S.; Kreutz, M. R.; Mikhaylova, M.
10.1101/2020.12.31.424970 — neuroscience — Posted on 2021-01-05
3854 OPA1 Deletion in Brown Adipose Tissue Improves Thermoregulation and Systemic Metabolism via FGF21
Pereira, R. O.; Marti, A.; Olvera, A. C.; Tadinada, S. M.; Bjorkman, S. H.; Weatherford, E. T.; Westphal, M.; Patel, P. H.; Kirby, A. K.; Hewezi, R.; Bui Tran, W.; Pena, L. M. G.; Souvenir, R. A.; Mital, M.; Adams, C. M.; Potthoff, M. J.; Abel, E. D.
10.1101/2021.01.04.425181 — physiology — Posted on 2021-01-05
3857 HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
Garcia-Dominguez, D. J.; Hajji, N.; Sanchez-Molina, S.; Figuerola, E.; de Pablos, R. M.; Espinosa-Oliva, A. M.; Andres-Leon, E.; Terron-Camero, L. C.; Flores-Campos, R.; Pascual-Pasto, G.; Robles, M. J.; Carcaboso, A. M.; Mora, J.; de Alava, E.; Hontecillas-Prieto, L.
10.1101/2021.01.04.425179 — cancer biology — Posted on 2021-01-05
3858 A Mechanistic Modeling Framework Reveals the Key Principles Underlying Tumor Metabolism
Tripathi, S.; Park, J. H.; Pudakalakatti, S.; Bhattacharya, P. K.; Kaipparettu, B. A.; Levine, H.
10.1101/2021.01.04.424598 — cancer biology — Posted on 2021-01-05
3859 Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
Rovsnik, U.; Zhuang, Y.; Forsberg, B. O.; Carroni, M.; Yvonnesdotter, L.; Howard, R. J.; Lindahl, E.
10.1101/2021.01.04.425171 — biochemistry — Posted on 2021-01-05
3861 Spatial population genomics of a recent mosquito invasion
Schmidt, T. L.; Swan, T.; Chung, J.; Karl, S.; Demok, S.; Yang, Q.; Field, M. A.; Muzari, M. O.; Ehlers, G.; Brugh, M.; Bellwood, R.; Horne, P.; Burkot, T. R.; Ritchie, S.; Hoffmann, A. A.
10.1101/2020.11.30.405191 — genomics — Posted on 2021-01-05
3864 Roles for ELMOD2 and Rootletin in Ciliogenesis
Turn, R. E.; Linnert, J.; Gigante, E. D.; Wolfrum, U.; Caspary, T.; Kahn, R. A.
10.1101/2021.01.04.425267 — cell biology — Posted on 2021-01-04
3866 Immunogenicity and protective efficacy of one- and two-dose regimens of the Ad26.COV2.S COVID-19 vaccine candidate in adult and aged rhesus macaques
Solforosi, L.; Kuipers, H.; Rosendahl Huber, S. K.; van der Lubbe, J. E. M.; Dekking, L.; Czapska-Casey, D. N.; Izquierdo Gil, A.; Baert, M.; Drijver, J.; Vaneman, J.; van Huizen, E.; Choi, Y.; Vreugdenhil, J.; Kroos, S.; de Wilde, A. H.; Kourkouta, E.; Custers, J.; Dalebout, T. J.; Myeni, S. K.; Kikkert, M.; Snijder, E. J.; Barouch, D. H.; Boszormenyi, K. P.; Stammes, M. A.; Kondova, I.; Verschoor, E. J.; Verstrepen, B. E.; Koopman, G.; Mooij, P.; Bogers, W. M. J. M.; van Heerden, M.; Muchene, L.; Tolboom, J. T. B. M.; Roozendaal, R.; Schuitemaker, H.; Wegmann, F.; Zahn, R. C.
10.1101/2020.11.17.368258 — immunology — Posted on 2021-01-04
3868 Spatial Clustering of CD68+ Tumor Associated Macrophages with Tumor Cells is Associated with Worse Overall Survival in Metastatic Clear Cell Renal Cell Carcinoma
Chakiryan, N. H.; Kimmel, G.; Kim, Y.; Hajiran, A.; Aydin, A.; Zemp, L.; Katende, E.; Nguyen, J.; Lopez-Blanco, N.; Chahoud, J.; Spiess, P.; Fournier, M.; Dhillon, J.; Wang, L.; Moran-Segura, C.; El-Kenawi, A.; Mule, J.; Altrock, P. M.; Manley, B. J.
10.1101/2021.01.04.425197 — cancer biology — Posted on 2021-01-04
3869 Structural basis for broad coronavirus neutralization
Sauer, M.; Park, Y.-J.; Tortorici, M. A.; Walls, A. C.; Homad, L.; Acton, O.; Bowen, J. E.; Wang, C.; Xiong, X.; de van der Schueren, W.; Quispe, J.; Bosch, B.-J.; Hoffstrom, B. G.; McGuire, A. T.; Veesler, D.
10.1101/2020.12.29.424482 — biochemistry — Posted on 2021-01-04
3871 Selection of popcorn genotypes tolerant to Spodoptera frugiperda and key traits related to the identification of tolerance
Kuroda, A. T.; Costa Rosa, J.; Almeida, L. F. A. d.; Garcia, G. D. L.; Demitto, G. A.; Souza, R. M. B. d.; Albuquerque, F. A. d.; Scapim, C. A.
10.1101/2021.01.04.425203 — genetics — Posted on 2021-01-04
3873 ERK signaling licenses SKN-1A/NRF1 for proteasome production and proteasomal stress resistance
Zhang, P.; Qu, H.-Y.; Wu, Z.; Na, H.; Hourihan, J.; Zhang, F.; Zhu, F.; Isik, M.; Walhout, A. J. M.; Feng, Y.-X.; Blackwell, K.
10.1101/2021.01.04.425272 — cell biology — Posted on 2021-01-04
3875 A workflow for simultaneous detection of coding and non-coding transcripts by ribosomal RNA-depleted RNA-Seq.
Williams, J. M.; Potemkin, N.; Cawood, S.; Treece, J.; Guevremont, D.; Rand, C.; McLean, C.; Stanton, J.-A. L.
10.1101/2021.01.04.425201 — molecular biology — Posted on 2021-01-04
3876 TMPRSS2 structure-phylogeny repositions Avoralstat for SARS-CoV-2 prophylaxis in mice
Sun, Y. J.; Velez, G.; Parsons, D.; Li, K.; Ortiz, M.; Sharma, S.; McCray, P. B.; Bassuk, A. G.; Mahajan, V. B.
10.1101/2021.01.04.425289 — microbiology — Posted on 2021-01-04
3881 High transgene expression is associated with systemic GFP silencing in Nicotiana benthamiana
Hendrix, B.; Hoffer, P.; Sanders, R.; Schwartz, S.; Zheng, W.; Eads, B.; Taylor, D.; Deikman, J.
10.1101/2021.01.04.425204 — plant biology — Posted on 2021-01-04
3884 Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth
Gupta, S.; Yano, J. A.; Htwe Htwe, H.; Shin, H. R.; Cakir, Z.; Ituarte, T.; Wen, K. W.; Kim, G. E.; Zoncu, R.; Dawson, D. W.; Perera, R. M.
10.1101/2021.01.04.425106 — cancer biology — Posted on 2021-01-04
3885 Metronomic therapy prevents emergence of drug resistance by maintaining the dynamic of intratumor heterogeneity.
Bondarenko, M.; Le Grand, M.; Shaked, Y.; Raviv, Z.; Chapuisat, G.; Carrere, C.; Montero, M.-P.; Rossi, M.; Pasquier, E.; Carre, M.; Andre, N.
10.1101/2021.01.04.425214 — cancer biology — Posted on 2021-01-04
3886 H3K27me3 is a determinant of chemotolerance in triple-negative breast cancer
Marsolier, J.; Prompsy, P.; Durand, A.; Lyne, A.-M.; Landragin, C.; Trouchet, A.; Tenreira-bento, S.; Eisele, A.; Foulon, S.; Baudre, L.; Grosselin, K.; Bohec, M.; Baulande, S.; Dahmani, A.; Letouze, E.; Marangoni, E.; Perie, L.; Vallot, C.
10.1101/2021.01.04.423386 — cancer biology — Posted on 2021-01-04
3887 Phosphoproteomic Landscape of AML Cells Treated with the ATP-Competitive CK2 Inhibitor CX-4945
Rosales, M.; Rodriguez-Ulloa, A.; Besada, V.; Ramon, A. C.; Perez, G. V.; Ramos, Y.; Guirola, O.; Gonzalez, L. J.; Zettl, K.; Wisniewski, J. R.; Perera, Y.; Perea, S. E.
10.1101/2021.01.04.425248 — cancer biology — Posted on 2021-01-04
3888 Structural Characteristics and Proton Conductivity of the Gel Within the Electrosensory Organs of Cartilaginous Fishes
Phillips, M.; Wheeler, A.; Robinson, M. J.; Leppert, V.; Jia, M.; Rolandi, M.; Hirst, L. S.; Amemiya, C. T.
10.1101/2021.01.04.425255 — biophysics — Posted on 2021-01-04
3889 Genetic Diversity of Dianthus Plants Revealed by SRAP Markers
Wang, J.; Li, J.; Shi, G.; Hao, H.; Ji, Z.; Lai, Z.; Xing, G.
10.1101/2021.01.04.425199 — genetics — Posted on 2021-01-04
3892 Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy
Schmitt, R. E.; Smith, D. Y.; Cho, D. S.; Kirkeby, L. A.; Resch, Z. T.; Liewluck, T.; Niu, Z.; Milone, M.; Doles, J. D.
10.1101/2021.01.04.425299 — developmental biology — Posted on 2021-01-04
3893 Reduced miR-184-3p expression occurring in Type 2 diabetic pancreatic islets protects β-cells from lipotoxic and proinflammatory apoptosis via a CRTC1-dependent mechanism
Grieco, G. E.; Brusco, N.; Nigi, L.; Formichi, C.; Fignani, D.; Licata, G.; Marselli, L.; Marchetti, P.; Salvini, L.; Tinti, L.; Po, A.; Ferretti, E.; Sebastiani, G.; Dotta, F.
10.1101/2021.01.04.425234 — cell biology — Posted on 2021-01-04
3895 Genetic depletion studies define receptor usage by virulent hantaviruses in human endothelial cells
Dieterle, M. E.; Sola-Riera, C.; Jangra, R. K.; Ye, C.; Goodfellow, S. M.; Mittler, E.; Kasikci, E.; Bradfute, S. B.; Klingström, J.; Chandran, K.
10.1101/2020.12.30.424861 — microbiology — Posted on 2021-01-04
3896 Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus
Arunkumar, G. A.; Strohmeier, S.; Li, T.; Bhavsar, D.; Chromikova, V.; Amanat, F.; Bunyatov, M.; Wilson, P. C.; Ellebedy, A.; Boons, G.-J.; Simon, V.; de Vries, R. P.; Krammer, F.
10.1101/2021.01.04.425274 — microbiology — Posted on 2021-01-04
3899 Quantification of biologically and chemically bound phosphorus in activated sludge from full-scale plants with biological P-removal
Petriglieri, F.; Petersen, J. F.; Peces, M.; Nierychlo, M.; Hansen, K.; Baastrand, C. B.; Nielsen, U. G.; Reitzel, K.; Nielsen, P. H.
10.1101/2021.01.04.425262 — microbiology — Posted on 2021-01-04
3901 Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations
Swanson, O.; Rhodes, B.; Wang, A.; Shi-Mao, X.; Parks, R.; Sanzone, A.; Louder, M. K.; Lin, B. C.; Doria-Rose, N.; Bonsignori, M.; Saunders, K. O.; Wiehe, K.; Haynes, B. F.; Azoitei, M. L.
10.1101/2021.01.04.425252 — immunology — Posted on 2021-01-04
3902 Batf-mediated Epigenetic Control of Effector CD8+ T Cell Differentiation
Tsao, H.-W.; Kaminski, J.; Kurachi, M.; Barnitz, R. A.; DiIorio, M. A.; LaFleur, M. W.; Ise, W.; Kurosaki, T.; Wherry, E. J.; Haining, W. N.; Yosef, N.
10.1101/2021.01.04.425241 — immunology — Posted on 2021-01-04
3903 Preliminary report of preclinical efficacy and safety analysis of gamma-irradiated inactivated SARS-CoV-2 vaccine candidates, SK-01 version 1 and OZG-3861 version 1
SIR KARAKUS, G.; Tastan, C.; Dilek Kancagi, D.; Yurtsever, B.; Tumentemur, G.; Demir, S.; Turan, R. D.; Abanuz, S.; Cakirsoy, D.; Seyis, U.; Ozer, S.; Elibol, O.; Elek, M.; Ertop, G.; Arbak, S.; Acikel Elmas, M.; Hemsinlioglu, C.; Kocagoz, A. S.; Hatirnaz Ng, O.; Akyoney, S.; Sahin, I.; Ozbek, U.; Telci, D.; Sahin, F.; Yalcin, K.; Ovali, E.
10.1101/2020.09.04.277426 — immunology — Posted on 2021-01-04
3904 Evolution of Antibody Immunity to SARS-CoV-2
Gaebler, C.; Wang, Z.; Lorenzi, J. C. C.; Muecksch, F.; Finkin, S.; Tokuyama, M.; Cho, A.; Jankovic, M.; Schaefer-Babajew, D.; Oliveira, T. Y.; Cipolla, M.; Viant, C.; Barnes, C. O.; Hurley, A.; Turroja, M.; Gordon, K.; Millard, K. G.; Ramos, V.; Schmidt, F.; Weisblum, Y.; Jha, D.; Tankelevich, M.; Yee, J.; Shimeliovich, I.; Robbiani, D. F.; Zhao, Z.; Gazumyan, A.; Hatziioannou, T.; Bjorkman, P. J.; Mehandru, S.; Bieniasz, P. D.; Caskey, M.; Nussenzweig, M. C.; Hagglof, T.; Schwartz, R. E.; Bram, Y.; Martinez-Delgado, G.; Mendoza, P.; Breton, G.; Dizon, J.; Unson-O'Brien, C.; Patel, R.
10.1101/2020.11.03.367391 — immunology — Posted on 2021-01-04
3905 The impact of COVID-19 vaccination campaigns accounting for antibody-dependent enhancement
Adil M. Y., N.; Tsoungui Obama, H. C. J.; Ngucho Yvan Mbeutchou, J.; Kwamou Ngaha, S. F.; Kayanula, L.; Kamanga, G.; Ibrahim, T. B.; Bwanu Iliya, P.; Iyanda, S. B.; Alawam Nemer, L. H. M.; Helle, K. B.; Teboh-Ewungkem, M. I.; Schneider, K. A.
10.1101/2021.01.04.425198 — immunology — Posted on 2021-01-04
3907 HIV-1-induced apathy: Mitigation by the gut metabolite, S-equol
McLaurin, K. A.; Bertrand, S.; Illenberger, J.; Harrod, S.; Mactutus, C. F.; Booze, R.
10.1101/2021.01.04.425260 — neuroscience — Posted on 2021-01-04
3908 Dentate Gyrus and CA3 GABAergic Interneurons Bidirectionally Modulate Signatures of Internal and External Drive to CA1
Aery Jones, E. A.; Rao, A.; Zilberter, M.; Djukic, B.; Gillespie, A. K.; Koutsodendris, N.; Nelson, M.; Yoon, S. Y.; Huang, K.; Yuan, H.; Gill, T. M.; Huang, Y.; Frank, L. M.
10.1101/2021.01.04.425303 — neuroscience — Posted on 2021-01-04
3910 Assisted assembly of bacteriophage T7 core components for genome translocation across the bacterial envelope
Perez-Ruiz, M.; Pulido-Cid, M.; Luque-Ortega, J. R.; Valpuesta, J. M.; Cuervo, A.; Carrascosa, J. L.
10.1101/2021.01.04.424714 — biophysics — Posted on 2021-01-04
3912 Extracellular endosulfatase Sulf-2 harbours a chondroitin/dermatan sulfate chain that modulates its enzyme activity
El Masri, R.; Seffouh, A.; Roelants, C.; Seffouh, I.; Gout, E.; Perard, J.; Dalonneau, F.; Nishitsuji, K.; Noborn, F.; Nikpour, M.; Larson, G.; Cretinon, Y.; Uchimura, K.; Daniel, R.; Lortat-Jacob, H.; Filhol, O.; Vives, R. R.
10.1101/2021.01.04.425218 — biochemistry — Posted on 2021-01-04
3916 Neuromolecular and behavioral effects of ethanol deprivation in Drosophila
D'Silva, N. M.; McCullar, K. S.; Conard, A. M.; Blackwater, T.; Azanchi, R.; Heberlein, U.; Larschan, E. M.; Kaun, K. R.
10.1101/2021.01.02.425101 — neuroscience — Posted on 2021-01-04
3919 Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors
Molina, L. M.; Zhu, J.; Li, Q.; Pradhan-Sundd, T.; Sayed, K.; Jenkins, N.; Vats, R.; Ko, S.; Hu, S.; Poddar, M.; Singh, S.; Tao, J.; Sundd, P.; Singhi, A.; Watkins, S. C.; Ma, X.; Benos, P. V.; Feranchak, A.; Nejak-Bowen, K.; Watson, A.; Bell, A.; Monga, S. P.
10.1101/2020.10.21.349159 — pathology — Posted on 2021-01-04
3920 Structural Basis for Allosteric Control of the SERCA-Phospholamban Membrane Complex by Ca2+ and cAMP-dependent Phosphorylation
Weber, D. K.; Hernandez, M. S.; Reddy, V. U.; Wang, S.; Larsen, E. K.; Tata, G.; Gustavsson, M.; Cornea, R. L.; Thomas, D. D.; De Simone, A.; Veglia, G.
10.1101/2020.08.28.271940 — biophysics — Posted on 2021-01-04
3921 Building blocks of protein structures - Physics meets Biology
Skrbic, T.; Maritan, A.; Giacometti, A.; Rose, G. D.; Banavar, J. R.
10.1101/2020.11.10.375105 — biophysics — Posted on 2021-01-04
3922 AdRoit: an accurate and robust method to infer complex transcriptome composition
Yang, T.; Alessandri-Haber, N.; Fury, W.; Schaner, M.; Breese, R.; LaCroix-Fralish, M.; Kim, J.; Adler, C.; Macdonald, L. E.; Atwal, G. S.; Bai, Y.
10.1101/2020.12.14.422697 — bioinformatics — Posted on 2021-01-04
3926 Talin-vinculin precomplex drives adhesion maturation by accelerated force transmission and vinculin recruitment
Han, S. J.; Azarova, E. V.; Whitewood, A. J.; Bachir, A.; Guttierrez, E.; Groisman, A.; Horwitz, A. R.; Goult, B. T.; Dean, K.; Danuser, G.
10.1101/735183 — cell biology — Posted on 2021-01-04
3927 Amyloid beta acts synergistically as a pro-inflammatory cytokine
LaRocca, T. J.; Cavalier, A. N.; Roberts, C. M.; Lemieux, M. R.; Link, C. D.
10.1101/2020.09.28.316927 — molecular biology — Posted on 2021-01-04
3928 A parental transcriptional response to microsporidia infection induces inherited immunity in offspring
Willis, A. R.; Zhao, W.; Sukhdeo, R.; Wadi, L.; Tamim El Jarkass, H.; Claycomb, J. M.; Reinke, A. W.
10.1101/2020.10.11.335117 — microbiology — Posted on 2021-01-04
3930 TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
Lehmkuhl, E. M.; Loganathan, S.; Alsop, E.; Blythe, A. D.; Kovalik, T.; Barrameda, D.; Kueth, C.; Eck, R. J.; Siddegowda, B. B.; Joardar, A.; Mortimore, N. P.; Bowser, R.; Van Keuren-Jensen, K.; Zarnescu, D. C.; Macias, M. E.; Ball, H.
10.1101/2020.07.01.182360 — neuroscience — Posted on 2021-01-04
3932 Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor
Williams, C. H.; Neitzel, L. R.; Karki, P.; Thayer, T. E.; Keyesr, B. D.; Wells, Q. S.; Perry, J. A.; Birukov, K.; Birukova, A.; Hong, C. C.
10.1101/612549 — cancer biology — Posted on 2021-01-04
3937 Folding and Persistence Time of Intramolecular G-Quadruplexes Transiently Embedded in a DNA duplex
Tran, P. L. T.; Rieu, M.; Hodeib, S.; Joubert, A.; Ouellet, J.; Alberti, P.; Bugaut, A.; Allemand, J.-F.; Boule, J.-B.; Croquette, V.
10.1101/2021.01.04.425278 — biophysics — Posted on 2021-01-04
3939 Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck
Braun, K. M.; Moreno, G. K.; Halfmann, P. J.; Hodcroft, E. B.; Baker, D. A.; Boehm, E. C.; Weiler, A. M.; Haj, A. K.; Hatta, M.; Chiba, S.; Maemura, T.; Kawaoka, Y.; Koelle, K.; O'Connor, D.; Friedrich, T.
10.1101/2020.11.16.384917 — microbiology — Posted on 2021-01-04
3940 Spike protein disulfide disruption as a potential treatment for SARS-CoV-2
Grishin, A. M.; Dolgova, N. V.; Harms, S.; Pickering, I. J.; George, G. N.; Falzarano, D.; Cygler, M.
10.1101/2021.01.02.425099 — microbiology — Posted on 2021-01-04
3948 Bromodomain 4 inhibition leads to MYCN downregulation in Wilms' tumor cells
Woods, A. D.; Keller, C.; Berlow, N. E.; Michalek, J. E.; Royer-Pokora, B.; Purohit, R.; Tranbarger Freier, K. E.; Lathara, M.; Matlock, K.; Srivivasa, G.; Veselska, R.
10.1101/2021.01.04.425208 — cancer biology — Posted on 2021-01-04
3949 Inhibition of Extracellular Vesicle-Associated MMP2 Abrogates Intercellular Transfer of Hepatic miR-122 to Tissue Macrophages and Curtails Liver Inflammation
Das, A.; Basu, S.; Bandyopadhyay, D.; Datta, D.; Chakraborty, S.; Adak, M.; Swarnakar, S.; Chakrabarti, P.; Bhattacharyya, S. N.
10.1101/2021.01.04.425217 — cancer biology — Posted on 2021-01-04
3958 Urban-adapted mammal species have more known pathogens
Albery, G. F.; Carlson, C. J.; Cohen, L. E.; Eskew, E. A.; Gibb, R.; Ryan, S. J.; Sweeny, A. R.; Becker, D. J.
10.1101/2021.01.02.425084 — ecology — Posted on 2021-01-04
3962 Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
Bui, L. T.; Winters, N. I.; Chung, M.-I.; Joseph, C.; Gutierrez, A. J.; Habermann, A. C.; Adams, T. S.; Schupp, J. C.; Poli, S.; Peter, L. M.; Taylor, C. J.; Blackburn, J. B.; Richmond, B. W.; Nicholson, A. G.; Rassl, D.; Wallace, W. A.; Rosas, I. O.; Jenkins, R. G.; Kaminski, N.; Kropski, J. A.; Banovich, N. E.; Human Cell Atlas Lung Biological Network,
10.1101/2020.10.20.347187 — cell biology — Posted on 2021-01-04
3963 Nsp1 of SARS-CoV-2 Stimulates Host Translation Termination
Shuvalov, A.; Shuvalova, E.; Biziaev, N.; Sokolova, E.; Evmenov, K.; Egorova, T.; Alkalaeva, E.
10.1101/2020.11.11.377739 — molecular biology — Posted on 2021-01-04
3965 scRNA-seq Reveals A Macrophage Subset That Provides A Splenic Replication Niche For Intracellular Salmonella
Hoffman, D.; Avraham, R.; Tevet, Y.; Rosenberg, G.; Vainman, L.; Solomon, A.; Hen-Avivi, S.; Bossel Ben-Moshe, N.
10.1101/2021.01.04.425175 — immunology — Posted on 2021-01-04
3966 The RAG1 Ubiquitin Ligase Domain Enhances T Cell Receptor Gene Assembly and Thymic Selection
Burn, T.; Miot, C.; Kreiger, P.; Hayer, K.; Bhattacharyya, A.; Jones, J.; Bassing, C.; Behrens, E.
10.1101/2021.01.04.425211 — immunology — Posted on 2021-01-04
3968 Spatiotemporal dynamics between interictal epileptiform discharges and ripples during associative memory processing
Henin, S.; Shankar, A.; Borges, H.; Flinker, A.; Doyle, W.; Friedman, D.; Devinsky, O.; Buzsaki, G.; Liu, A.
10.1101/2020.07.22.216416 — neuroscience — Posted on 2021-01-04
3976 Photosynthetic acclimation and sensitivity to short- and long-term environmental changes
Schonbeck, L.; Grossiord, C.; Gessler, A.; Gisler, J.; Meusburger, K.; D'Odorico, P.; Rigling, A.; Salmon, Y.; Stocker, B. D.; Zweifel, R.; Schaub, M.
10.1101/2021.01.04.425174 — plant biology — Posted on 2021-01-04
3979 A systematic CRISPR screen reveals an IL-20/IL20RA-mediated peritoneal immune crosstalk to prevent the ovarian cancer metastasis
Li, J.; Qin, X.; Shi, J.; Wang, X.; Li, T.; Xu, M.; Chen, X.; Zhao, Y.; Han, J.; Piao, Y.; Zhang, W.; Qu, P.; Wang, L.; Xiang, R.; Shi, Y.
10.1101/2021.01.03.425154 — cancer biology — Posted on 2021-01-04
3981 Mapping the mechanical microenvironment in the ovary
Hopkins, T. I. R.; Bemmer, V. L.; Franks, S.; Dunlop, C.; Hardy, K.; Dunlop, I. E.
10.1101/2021.01.03.425098 — biophysics — Posted on 2021-01-04
3984 Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2
Liu, L.; Chopra, P.; Li, X.; Bouwman, K. M.; Tompkins, S. M.; Wolfert, M. A.; de Vries, R. P.; Boons, G.-J.
10.1101/2020.05.10.087288 — biochemistry — Posted on 2021-01-04
3985 Pan-genome Analysis in Sorghum Highlights the Extent of Genomic Variation and Sugarcane Aphid Resistance Genes
Wang, B.; Jiao, Y.; Chougule, K.; Olson, A.; Huang, J.; Llaca, V.; Fengler, K.; Wei, X.; Wang, L.; Wang, X.; Regulski, M.; Drenkow, J.; Gingeras, T. R.; Hayes, C.; Armstrong, J. S.; Huang, Y.; Xin, Z.; Ware, D.
10.1101/2021.01.03.424980 — genomics — Posted on 2021-01-04
3987 Pulled Diversification Rates, Lineage-Through-Time Plots and Modern Macroevolutionary Modelling
Helmstetter, A. J.; Glemin, S.; Kafer, J.; Zenil-Ferguson, R.; Sauquet, H.; de Boer, H.; Dagallier, L.-P. M.; Mazet, N.; Reboud, E. L.; Couvreur, T. L.; Condamine, F. L.
10.1101/2021.01.04.424672 — evolutionary biology — Posted on 2021-01-04
3992 Small mitochondrial protein NERCLIN regulates cardiolipin homeostasis and mitochondrial ultrastructure.
Konovalova, S.; Torregrosa-Munumer, R.; Manjunath, P.; Baral, S.; Liu, X.; Holopainen, M.; Kvist, J.; Rajendran, J.; Yang, Y.; Varjosalo, M.; Käkelä, R.; Somerharju, P.; Tyynismaa, H.
10.1101/2021.01.03.424667 — cell biology — Posted on 2021-01-04
3996 Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect after a Drug Repurposing Screen
Rodon, J.; Munoz-Basagoiti, J.; Perez-Zsolt, D.; Noguera-Julian, M.; Paredes, R.; Mateu, L.; Quinones, C.; Erkizia, I.; Blanco, I.; Valencia, A.; Guallar, V.; Carrillo, J.; Blanco, J.; Segales, J.; Clotet, B.; Vergara-Alert, J.; Izquierdo-Useros, N.
10.1101/2020.04.23.055756 — microbiology — Posted on 2021-01-04
3998 Spatiotemporal dynamics of human attention revealed byintracerebral recording
Seidel Malkinson, T.; Bayle, D. J.; Bourgeois, A.; Lehongre, K.; Fernandez, S.; Navarro, V.; Adam, C.; Margulies, D.; Sitt, J. D.; Bartolomeo, P.
10.1101/2021.01.02.425103 — neuroscience — Posted on 2021-01-04
4000 Aberrant Dynamic Functional Connectivity of Default Mode Network in Schizophrenia and Links to Symptom Severity
Sendi, M. S. E.; Zendehrouh, E.; Ellis, C. A.; Liang, Z.; Fu, Z.; Mathalon, D. H.; Ford, J. M.; Preda, A.; van Erp, T. G. M.; Miller, R. L.; Pearlson, G. D.; Turner, J. A.; Calhoun, V. D.
10.1101/2021.01.03.425152 — neuroscience — Posted on 2021-01-04
4001 Imaging Multiple Sclerosis Pathology at 160μm Isotropic Resolution by Human Whole-Brain Ex Vivo Magnetic Resonance Imaging at 3T
Weigel, M.; Dechent, P.; Galbusera, R.; Bahn, E.; Nair, G.; Kappos, L.; Brück, W.; Stadelmann, C.; Granziera, C.
10.1101/2021.01.03.425097 — neuroscience — Posted on 2021-01-04
4003 Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrPSc
Lakkaraju, A. K.; Sorce, S.; Senatore, A.; Nuvolone, M.; Guo, J.; Schwarz, P.; Moos, R.; Pelczar, P.; Aguzzi, A.
10.1101/2021.01.03.425136 — neuroscience — Posted on 2021-01-04
4004 Neuromolecular and behavioral effects of ethanol deprivation in Drosophila
D'Silva, N. M.; McCullar, K. S.; Conard, A. M.; Blackwater, T.; Azanchi, R.; Heberlein, U.; Larschan, E. M.; Kaun, K. R.
10.1101/2021.01.02.425101 — neuroscience — Posted on 2021-01-04
4010 LocusZoom.js: Interactive and embeddable visualization of genetic association study results
Boughton, A. P.; Welch, R. P.; Flickinger, M.; VandeHaar, P.; Taliun, D.; Abecasis, G. R.; Boehnke, M.
10.1101/2021.01.01.423803 — bioinformatics — Posted on 2021-01-04
4012 Priming mycobacterial ESX-secreted protein B to form a channel-like structure
Gijsbers, A.; Vinciauskaite, V.; Siroy, A.; Gao, Y.; Tria, G.; Mathew, A.; Sanchez-Puig, N.; Lopez-Iglesias, C.; Peters, P. P.; Ravelli, R. R.
10.1101/2021.01.02.425093 — biochemistry — Posted on 2021-01-04
4013 Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro
Garcia-Alonso, L.; Handfield, L.-F.; Roberts, K.; Nikolakopoulou, K.; Fernando, R. C.; Gardner, L.; Woodhams, B.; Arutyunyan, A.; Polanski, K.; Hoo, R.; Sancho-Serra, C.; Li, T.; Kwakwa, K.; Tuck, E.; Kleshchevnikov, V.; Tarkowska, A.; Porter, T.; Mazzeo, C. I.; van Dongen, S.; Dabrowska, M.; Vaskivskyi, V.; Mahbubani, K. T.; PARK, J.-E.; Jimenez-Linan, M.; Campos, L.; Kiselev, V.; Lindskog, C.; Ayuk, P.; Prigmore, E.; Stratton, M. R.; Saeb-Parsy, K.; Moffett, A.; Moore, L.; Bayraktar, O. A.; Teichmann, S. A.; Turco, M. Y.; Vento-Tormo, R.
10.1101/2021.01.02.425073 — genomics — Posted on 2021-01-04
4017 12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes
Kulkarni, A.; Pineros, A. R.; Ibrahim, S.; Hernandez-Perez, M.; Orr, K. S.; Glenn, L.; Walsh, M.; Nadler, J. L.; Morris, M. A.; Tersey, S. A.; Mirmira, R. G.; Anderson, R. M.
10.1101/2021.01.02.424855 — immunology — Posted on 2021-01-04
4019 MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis
Kantar, D.; Bousquet Mur, E.; Mancini, M.; Slaninova, V.; Ben Salah, Y.; Costa, L.; Forest, E.; Lassus, P.; Geminard, C.; Boissiere-Michot, F.; Orsetti, B.; Theillet, C.; Colinge, J.; Benistant, C.; Maraver, A.; Heron-Milhavet, L.; Djiane, A.
10.1101/2020.06.13.149724 — cancer biology — Posted on 2021-01-04
4020 FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.
Yamawaki, K.; Shiina, I.; Murata, T.; Tateyama, S.; Maekawa, Y.; Niwa, M.; Shimonaka, M.; Okamoto, K.; Suzuki, T.; Nishida, T.; Abe, R.; Obata, Y.
10.1101/2021.01.01.424454 — cancer biology — Posted on 2021-01-04
4026 Machine Learning to Summarize and Provide Context for Sleep and Eating Schedules.
Chen, T.; Chen, Y.; Gao, J.; Gao, P.; Moon, J. H.; Ren, J.; Zhu, R.; Song, S.; Clark, J. M.; Bennett, W.; Lehman, H.; Budavari, T.; Woolf, T.
10.1101/2020.12.31.424983 — bioinformatics — Posted on 2021-01-04
4027 Mining underutilized whole-genome sequencing projects to improve 16S rRNA databases
Nolan, B.; Abram, F.; Brennan, F.; Holmes, A.; O'Flaherty, V.; Pritchard, L.; Waters, N. R.
10.1101/2021.01.01.425045 — bioinformatics — Posted on 2021-01-04
4029 Dimerization mechanism and structural features of human LI-cadherin
Yui, A.; Caaveiro, J. M. M.; Kuroda, D.; Nakakido, M.; Nagatoishi, S.; Goda, S.; Maruno, T.; Uchiyama, S.; Tsumoto, K.
10.1101/2020.09.18.291195 — biochemistry — Posted on 2021-01-04
4030 The histologic phenotype of lung cancers may be driven by transcriptomic features rather than genomic characteristics
Tang, M.; Abbas, H. A.; Negrao, M. V.; Ramineni, M.; Hu, X.; Fujimoto, J.; Reuben, A.; Varghese, S.; Zhang, J.; Li, J.; Chow, C.-W.; Mao, X.; Song, X.; Lee, W.-c.; Wu, J.; Little, L.; Gumbs, C.; Behrens, C.; Moran, C.; Weissferdt, A.; Lee, J. J.; Sepesi, B.; Swisher, S.; Heymach, J. V.; Wistuba, I. I.; Futreal, P. A.; Kalhor, N.; Zhang, J.
10.1101/2021.01.01.425056 — genomics — Posted on 2021-01-04
4032 Identification of Discriminative Gene-level and Protein-level Features Associated with Gain-of-Function and Loss-of-Function Mutations
Sevim Bayrak, C.; Jain, A.; Stein, D.; Chaudhary, K.; Nadkarni, G.; Van Vleck, T. T.; Boisson-Dupuis, S.; Stenson, P.; Cooper, D. N.; Schlessinger, A. N.; Itan, Y.
10.1101/2021.01.01.424981 — genetics — Posted on 2021-01-04
4038 CAR/Nr1i3 directs T cell adaptation to bile acids in the small intestine
Chen, M. L.; Huang, X.; Wang, H.; Liu, Y.; Shang, J.; Eliason, A.; Hegner, C.; Park, H.; Frey, B.; Wang, G.; Kojetin, D. J.; Weaver, C. T.; Pipkin, M. E.; Moore, D. D.; Sundrud, M. S.
10.1101/2020.07.30.229864 — immunology — Posted on 2021-01-04
4040 Role of hypothalamic MAPK/ERK signaling in diabetes remission induced by the central action of fibroblast growth factor 1
Brown, J. M.; Bentsen, M. A.; Rausch, D. M.; Phan, B. A.; Wieck, D.; Wasanwala, H.; Matsen, M. E.; Acharya, N.; Richardson, N.; Zhao, X.; Zhai, P.; Secher, A.; Morton, G. J.; Pers, T. H.; Schwartz, M. W.; Scarlett, J. M.
10.1101/2020.12.24.424313 — neuroscience — Posted on 2021-01-04
4042 Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2
Xie, Y.; Clarke, B. P.; Kim, Y. J.; Ivey, A. L.; Hill, P. S.; Shi, Y.; Ren, Y.
10.1101/2021.01.04.425184 — biophysics — Posted on 2021-01-04
4046 POT1 Stability and Binding Measured by Fluorescence Thermal Shift Assays
DeLeeuw, L. W.; Monsen, R. C.; Petrauskas, V.; Gray, R. D.; Baranauskiene, L.; Matulis, D.; Trent, J. O.; Chaires, J.
10.1101/2021.01.01.425048 — biophysics — Posted on 2021-01-04
4048 The engineered peptide construct NCAM1-Aβ inhibits aggregation of the human prion protein (PrP)
Gielnik, M.; Zhukova, L.; Zhukov, I.; Graslund, A.; Kozak, M.; Warmlander, S. K. T. S.
10.1101/2021.01.04.425177 — biochemistry — Posted on 2021-01-04
4049 6-gingerol interferes with amyloid-beta (Aβ) peptide aggregation
Berntsson, E.; Paul, S.; Sholts, S. B.; Jarvet, J.; Barth, A.; Graslund, A.; Warmlander, S. K. T. S.
10.1101/2021.01.03.425159 — biochemistry — Posted on 2021-01-04
4050 S. aureus-serine protease-like protein B (SplB) activates PAR2 and induces endothelial barrier dysfunction
Chandrabalan, A.; Thibeault, P. E.; Deinhardt-Emmer, S.; Nordengrün, M.; Iqbal, J.; Mrochen, D. M.; Mittmann, L. A.; Chamling, B.; Reichel, C. A.; Ramachandran, R.; Bröker, B. M.; Darisipudi, M. N.
10.1101/2020.12.30.424670 — immunology — Posted on 2021-01-04
4051 De novo germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice
Foray, A.-P.; Candon, S.; Hildebrand, S.; Marquet, C.; Valette, F.; Pecquet, C.; Lemoine, S.; Langa-Vives, F.; Dumas, M.; Hu, P.; Santamaria, P.; Lyon, S.; Scott, L.; Bu, C. H.; Wang, T.; Xu, D.; Moresco, E. M. Y.; Scazzocchio, C.; Bach, J.-F.; Beutler, B.; Chatenoud, L.
10.1101/2020.12.30.424747 — immunology — Posted on 2021-01-04
4052 Lithium ions display weak interaction with amyloid-beta (Aβ) peptides and have minor effects on their aggregation
Berntsson, E.; Paul, S.; Vosough, F.; Sholts, S. B.; Jarvet, J.; Roos, P. M.; Barth, A.; Graslund, A.; Warmlander, S. K. T. S.
10.1101/2021.01.03.425155 — biochemistry — Posted on 2021-01-04
4053 Specific cognitive signatures of information seeking in controllable environments
Rouault, M.; Weiss, A.; Lee, J. K.; Boute, J.; Drugowitsch, J.; Chambon, V.; Wyart, V.
10.1101/2021.01.04.425114 — neuroscience — Posted on 2021-01-04
4054 Effects of chronic lithium treatment on anxious behaviors and serotonergic genes expression in the midbrain raphe nuclei in defeated male mice
Smagin, D. A.; Kovalenko, I. L.; Galyamina, A. G.; Belozertseva, I. V.; Tamkovich, N. V.; Baranov, K. O.; Kudryavtseva, N. N.
10.1101/2021.01.04.425168 — neuroscience — Posted on 2021-01-04
4055 In vivo super-resolution track-density imaging for thalamic nuclei identification
Basile, G. A.; Bertino, S.; Bramanti, A.; Anastasi, G. P.; Milardi, D.; Cacciola, A.
10.1101/2021.01.03.425122 — neuroscience — Posted on 2021-01-04
4059 Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis
Reddy, H. M.; Bhattacharya, R.; Jehan, Z.; Mishra, K.; Annapurna, P.; Tiwari, S.; Praveena, N. M.; Alex, J. L.; Dhople, V. M.; Singh, L.; Sivaramakrishnan, M.; Chaturvedi, A.; Rangaraj, N.; Shiju, T. M.; Sridevi, B.; Kumar, S.; Dereddi, R. R.; Rayabandla, S.; Jesudasan, R. A.
10.1101/285429 — genomics — Posted on 2021-01-04
4064 Sequencing of clinical samples reveals that adaptation keeps establishing during H7N9 virus infection in humans
Li, L.; Ma, J.; Li, J.; Yuan, J.; Su, W.; Jin, T.; Wang, X.; Zhang, R.; Zou, R.; Li, L.; Li, J.; Fang, S.; Yuan, J.; Yang, C.; Qi, Y.; Gao, Q.; Ji, J.; Ma, K.; Fan, G.; Pei, N.; Deng, Y.; Zhou, Y.; Lin, D.; Li, F.; Ouyang, W.; Jia, H.; Liu, X.; Jiang, H.; Yang, H.; Xu, X.; Wang, H.; Liu, Y.
10.1101/2020.12.30.424890 — microbiology — Posted on 2021-01-03
4065 Colour Ambiguity In Real Scenes And The Role Of Perceptual Organisation
Werner, A. M.; Schmidt, A. M.; Hilmers, J.; Boborzi, L.; Weigold, M.
10.1101/2021.01.03.423255 — neuroscience — Posted on 2021-01-03
4067 Chromatin Interaction Neural Network (ChINN): A machine learning-based method for predicting chromatin interactions from DNA sequences
Cao, F.; Zhang, Y.; Cai, Y.; Animesh, S.; Zhang, Y.; Akincilar, S.; Loh, Y. P.; Chng, W. J.; Tergaonkar, V.; Kwoh, C. K.; Fullwood, M.
10.1101/2020.12.30.424817 — bioinformatics — Posted on 2021-01-03
4071 Distribution of Huntington's disease Haplogroups in Indian population
V, S. D.; Ratna, N.; Lakshmi, S.; Murari, G.; Kamble, N.; Yadav, R.; Viswanath, B.; Varghese, M.; Pal, P.; Jain, S.; Purushottam, M.
10.1101/2020.12.31.424975 — neuroscience — Posted on 2021-01-03
4073 Cellular mechanisms of heterogeneity in NF2-mutant schwannoma
MacKenzie, C. C.; Liu, C. H.; Vitte, J.; Giovannini, M.; McClatchey, A. I.
10.1101/2020.12.31.424999 — cancer biology — Posted on 2021-01-03
4074 Wide occurrence of putative mobilized colistin resistance genes in the human gut microbiome
Andrade, B. G.; Goris, T.; Afli, H.; Coutinho, F. H.; Davila, A. M. R.; Cuadrat, R. R. d. C.
10.1101/2020.12.31.424960 — bioinformatics — Posted on 2021-01-03
4079 Time-dependent pleiotropic phenotypes are caused by progressive DNA polymerase α deficiency in zebrafish
Lin, A. Y.-S.; Thomas, G. K.; Ang, K.; van Rossum, D. B.; Canfield, V. A.; Cheng, K. C.
10.1101/2020.12.31.425001 — genetics — Posted on 2021-01-03
4082 PD-L1+ and Hyal2+ myeloid cells in renal cell carcinoma: a case report
Kwenda, E.; Domiguez Gutierrez, P. R.; O'Malley, P.; Crispen, P. L.; Kusmartsev, S.
10.1101/2020.12.29.424690 — cell biology — Posted on 2021-01-03
4087 A metagenomic-based stufy of two sites from the Barbadian reef system
Hallett, M. T.; Simpson, S.; Bettauer, V.; Ramachandran, A.; Kramer, S.; Mahon, S.; Medina, M.; Valles, Y.; Dumeaux, V.; Valles, H.; Walsh, D. A.
10.1101/2021.01.02.425083 — microbiology — Posted on 2021-01-03
4088 Paired heavy and light chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses
Banach, B. B.; Cerutti, G.; Fahad, A. S.; Shen, C.-H.; Oliveira de Souza, M.; Katsamba, P. S.; Tsybovsky, Y.; Wang, P.; Nair, M. S.; Huang, Y.; Francino Urdaniz, I. M.; Steiner, P. J.; Gutierrez-Gonzalez, M.; Liu, L.; Lopez Acevedo, S. N.; Nazzari, A.; Wolfe, J. R.; Luo, Y.; Olia, A. S.; Teng, I.-T.; Yu, J.; Zhou, T.; Reddem, E. R.; Bimela, J.; Pan, X.; Madan, B.; Laflin, A. D.; Nimrania, R.; Yuen, K.-T.; Whitehead, T. A.; Ho, D. D.; Kwong, P. D.; Shapiro, L.; DeKosky, B. J.
10.1101/2020.12.31.424987 — immunology — Posted on 2021-01-03
4089 Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface
Zost, S. J.; Dong, J.; Gilchuk, I. M.; Gilchuk, P.; Thornburg, N. J.; Bangaru, S.; Kose, N.; Finn, J. A.; Bombardi, R.; Soto, C.; Nargi, R. S.; Irving, R. P.; Suryadevara, N.; Westover, J. B.; Carnahan, R. H.; Turner, H. L.; Li, S.; Ward, A. B.; Crowe, J. E.
10.1101/2020.12.31.424868 — immunology — Posted on 2021-01-03
4090 Disrupted dynamic functional network connectivity among cognitive control networks in the progression of Alzheimer's disease
Sendi, M. S. E.; Zendehrouh, E.; Fu, Z.; Liu, J.; Du, Y.; Mormino, E. C.; Salat, D. H.; Miller, R. L.; Calhoun, V.
10.1101/2020.12.31.424877 — neuroscience — Posted on 2021-01-03
4091 A Nanoceutical Agent for Chemoprevention of Bilirubin Encephalopathy
Adhikari, A.; Bhutani, V. K.; Mondal, S.; Das, M.; Darbar, S.; Ghosh, R.; Polley, N.; Das, A. K.; Bhattacharya, S. S.; Mallick, A. K.; Pal, S. K.
10.1101/2020.12.31.425023 — pharmacology and toxicology — Posted on 2021-01-03
4092 The DAXX-SREBP axis promotes oncogenic lipogenesis and tumorigenesis
Mahmud, I.; Tian, G.; Wang, J.; Lewis, J.; Waddell, A.; Lydon, M. L.; Zhao, L. Y.; Li, J.-L.; Purayil, H. T.; Huo, Z.; Daaka, Y.; Garrett, T. J.; Liao, D.
10.1101/2020.12.31.424997 — cancer biology — Posted on 2021-01-03
4093 SERS uncovers the link between conformation of cytochrome c heme and mitochondrial membrane potential
Brazhe, N. A.; Nikelshparg, E. I.; Baizhumanov, A. A.; Grivennikova, V. G.; Semenova, A. A.; Novikov, S. M.; Volkov, V. S.; Arsenin, A. V.; Yakubovsky, D. I.; Evlyukhin, A. B.; Bochkova, Z. V.; Goodilin, E. A.; Maksimov, G. V.; Sosnovtseva, O.; Rubin, A. B.
10.1101/2021.01.03.425119 — biophysics — Posted on 2021-01-03
4094 Mechanistic Insight from Full Quantum Mechanical Modeling: Laccase as a Detoxifier of Aflatoxins
Zaccaria, M.; Dawson, W.; Kish, D. R.; Reverberi, M.; Bonaccorsi di Patti, M. C.; Domin, M.; Cristiglio, V.; Dellafiora, L.; Gabel, F.; Nakajima, T.; Genovese, L.; Momeni, B.
10.1101/2020.12.31.424992 — biophysics — Posted on 2021-01-03
4101 Distinct cryo-EM Structure of α-synuclein Filaments derived by Tau
Hojjatian, A.; Dasari, A.; Sengupta, U.; Taylor, D.; Daneshparvar, N.; Yeganeh, F. A.; Dillard, L.; Michael, B.; Griffin, R. G.; Borgnia, M. J.; Kayed, R.; Taylor, K. A.; Lim, K. H.
10.1101/2020.12.31.424989 — biochemistry — Posted on 2021-01-03
4103 In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesions
Nicolas, C.; Van Lith, C.; Allen, K.; Hickey, R.; Du, Z.; Hillin, L.; Guthman, R.; Cao, W.; Bhagwate, A.; O'Brien, D.; Kocher, J.-P.; Kaiser, R. A.; Russell, S.; Lillegard, J.
10.1101/2021.01.02.425079 — cell biology — Posted on 2021-01-03
4108 Retroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular Damage
Branscome, H.; Yin, D.; Jacob, S.; Cowen, M.; Kim, Y.; Khatkar, P.; Erickson, J.; El-Hage, N.; Liotta, L. A.; Kashanchi, F.
10.1101/2020.12.31.424849 — cell biology — Posted on 2021-01-03
4109 Knowledge graph analytics platform with LINCS and IDG for Parkinson's disease target illumination
Yang, J. J.; Gessner, C. R.; Duerksen, J. L.; Biber, D.; Binder, J. L.; Ozturk, M.; Foote, B.; McEntire, R.; Stirling, K.; Ding, Y.; Wild, D. J.
10.1101/2020.12.30.424881 — bioinformatics — Posted on 2021-01-03
4110 Transcriptomics data availability and reusability in the transition from microarray to next-generation sequencing
Rustici, G.; Williams, E.; Barzine, M.; Brazma, A.; Bumgarner, R.; Chierici, M.; Furlanello, C.; Greger, L.; Jurman, G.; Miller, M.; Ouellette, B. F. F.; Quackenbush, J.; Reich, M.; Stoeckert, C. J.; Taylor, R. C.; Trutane, S. C.; Weller, J.; Wilhelm, B.; Winegarden, N.
10.1101/2020.12.31.425022 — bioinformatics — Posted on 2021-01-03
4111 Empirical variance component regression for sequence-function relationships
Zhou, J.; Wong, M. S.; Chen, W.-C.; Krainer, A. R.; Kinney, J. B.; McCandlish, D. M.
10.1101/2020.10.14.339804 — evolutionary biology — Posted on 2021-01-03
4114 Characterisation of growth plate dynamics in murine models of osteoarthritis
Samvelyan, H. J.; Madi, K.; Tornqvist, A. E.; Javaheri, B.; Staines, K. A.
10.1101/2020.10.14.339119 — physiology — Posted on 2021-01-03
4115 A persistent giant algal virus, with a unique morphology, encodes an unprecedented number of genes involved in energy metabolism
Blanc-Mathieu, R.; Dahle, H.; Hofgaard, A.; Brandt, D.; Ban, H.; Kalinowski, J.; Ogata, H.; Sandaa, R.-A.
10.1101/2020.07.30.228163 — microbiology — Posted on 2021-01-03
4117 Classification of Sex and Alzheimers Disease via Brain Imaging-Based Deep Learning on 85,721 Samples
Lu, B.; Li, H.-X.; Chang, Z.-K.; Li, L.; Chen, N.-X.; Zhu, Z.-C.; Zhou, H.-X.; Fan, Z.; Yang, H.; Chen, X.; Yan, C.-G.
10.1101/2020.08.18.256594 — neuroscience — Posted on 2021-01-03
4120 Helicase-Like Functions in Phosphate Loop Containing Beta-Alpha Polypeptides
Vyas, P.; Trofimyuk, O.; Longo, L. M.; Deshmukh, F. K.; Sharon, M.; Tawfik, D. S.
10.1101/2020.07.30.228619 — molecular biology — Posted on 2021-01-03
4121 Genomic Background Governs Opposing Responses to Nalidixic Acid Upon Megaplasmid Acquisition in Pseudomonas
Baltrus, D. A.; Smith, C.; Derrick, M.; Leligdon, C.; Rosenthal, Z.; Mollico, M.; Moore, A.; Clark, M.
10.1101/832428 — microbiology — Posted on 2021-01-03
4124 Human brain region-specific variably methylated regions (VMRs) are enriched for heritability of distinct neuropsychiatric traits
Rizzardi, L. F.; Hickey, P. F.; Idrizi, A.; Tryggvadottir, R.; Callahan, C. M.; Stephens, K. E.; Taverna, S. D.; Zhang, H.; Ramazanoglu, S.; GTEx Consortium, ; Hansen, K. D.; Feinberg, A. P.
10.1101/2021.01.02.425010 — genomics — Posted on 2021-01-02
4129 The solution structure of Dead End bound to AU-rich RNA reveals an unprecedented mode of tandem RRM-RNA recognition required for mRNA regulation
Duszczyk, M. M.; Wischnewski, H.; Kazeeva, T.; Loughlin, F. E.; von Schroetter, C.; Pradere, U.; Hall, J.; Ciaudo, C.; Allain, F. H.- T.
10.1101/572156 — molecular biology — Posted on 2021-01-02
4130 Novel antibiotic mode of action by repression of promoter isomerisation
Kerr, L.; Browning, D. F.; Lemonidis, K.; Salih, T.; Hunter, I. S.; Suckling, C. J.; Tucker, N. P.
10.1101/2020.12.31.424950 — molecular biology — Posted on 2021-01-02
4134 An amiRNA screen uncovers redundant CBF & ERF34/35 transcription factors that differentially regulate arsenite and cadmium responses
Xie, Q.; Yu, Q.; Jobe, T. O.; Pham, A.; Ge, C.; Guo, Q.; Liu, J.; Liu, H.; Zhang, H.; Zhao, Y.; Xue, S.; Hauser, F.; Schroeder, J. I.
10.1101/2020.12.30.424898 — plant biology — Posted on 2021-01-02
4136 Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies
Dong, H.; Liu, P.; Bai, M.; Wang, K.; Feng, R.; Zhu, D.; Sun, Y.; Mu, S.; Li, H.; Harmsen, M. M.; Sun, S.; Wang, X.; Guo, H.
10.1101/2020.12.31.424923 — biophysics — Posted on 2021-01-02
4137 The Crystal Structure of Bromide-bound GtACR1 Reveals a Pre-Activated State in the Transmembrane Anion Tunnel
Li, H.; Huang, C.-Y.; Govorunova, E. G.; Sineshchekov, O. A.; Wang, M.; Zheng, L.; Spudich, J. L.
10.1101/2020.12.31.424927 — biophysics — Posted on 2021-01-02
4138 Cas9-cleavage sequences in minimal plasmids enhance non-viral genome targeting of CARs in primary human T cells
Jing, R.; Jiao, P.; chen, j.; Meng, X.; Wu, X.; Duan, Y.; Shang, K.; Qian, L.; Huang, Y.; Liu, J.; Huang, T.; Jin, J.; Chen, W.; Zeng, X.; Yin, W.; Gao, X.; zhou, c.; Sedelain, M.; Sun, J.
10.1101/2020.12.31.424920 — bioengineering — Posted on 2021-01-02
4139 Dynamic Detection and Reversal of Myocardial Ischemia Using an Artificially Intelligent Bioelectronic Medicine
Ganzer, P. D.; Loeian, M. S.; Roof, S. R.; Teng, B.; Lin, L.; Friedenberg, D. A.; Baumgart, I. W.; Meyers, E. C.; Chun, K. S.; Rich, A.; Muir, W. W.; Weber, D. J.; Hamlin, R. L.
10.1101/2020.12.30.424900 — bioengineering — Posted on 2021-01-02
4142 Insights into Genome Recoding from the Mechanism of a Classic +1-Frameshifting tRNA
Gamper, H.; Li, H.; Masuda, I.; Robkis, D. M.; Christian, T.; Conn, A. B.; Blaha, g.; Petersson, E. J.; Gonzalez, R. L.; Hou, Y.-M.
10.1101/2020.12.31.424971 — biochemistry — Posted on 2021-01-02
4143 Single-cell and single-variant resolution analysis of clonal evolution in human liver cancer
Su, X.; Zhao, L.; Shi, Y.; Zhang, R.; Long, Q.; Bai, S.; Luo, Q.; Lin, Y.; Zou, X.; Ghazanfar, S.; Tao, K.; yang, g.; Wang, L.; He, K.-Y.; Cui, X.; He, J.; Wu, J.-X.; Han, B.; Wang, N.; Li, X.; Yang, P.; Hou, S.; Sun, J.; Yang, J. Y. H.; Chen, J.; Han, Z.-G.
10.1101/2020.12.30.424907 — genomics — Posted on 2021-01-02
4145 Alveolar type II cells harbouring SARS-CoV-2 show senescence with a proinflammatory phenotype
Evangelou, K.; Veroutis, D.; Foukas, P. G.; Paschalaki, K.; Kittas, C.; Tzioufas, A. G.; de Leval, L.; Vassilakos, D.; Barnes, P. J.; Gorgoulis, V.
10.1101/2021.01.02.424917 — cell biology — Posted on 2021-01-02
4146 Genomic insights of high-risk clones of ESBL-producing Escherichia coli isolated from community infections and commercial meat in Southern Brazil
Soncini, J. G.; Cerdeira, L.; Koga, V. L.; Tizura, A. T.; Fuga, B.; Nakazato, G.; Kobayashi, R.; Aires, C. A. M.; Lincopan, N.; Vespero, E. C.
10.1101/2020.12.31.424884 — microbiology — Posted on 2021-01-02
4149 YhcB (DUF1043), a novel cell division protein conserved across gamma-proteobacteria
Mehla, J.; Liechti, G.; Morgenstern, R. M.; Caufield, J. H.; Hosseinnia, A.; Gagarinova, A.; Phanse, S.; Brockett, M.; Sakhawalkarar, N.; Babu, M.; Xiao, R.; Montelionege, G. T.; Vorobiev, S.; den Blaauwen, T.; Hunt, J. F.; Uetz, P.
10.1101/2020.12.31.425005 — microbiology — Posted on 2021-01-02
4151 Intermittent bulk release of human cytomegalovirus through multivesicular bodies
Flomm, F. J.; Soh, T. K.; Schneider, C.; Britt, H. M.; Thalassinos, K.; Pfitzner, S.; Reimer, R.; Gruenewald, K.; Bosse, J. B.
10.1101/2020.12.31.424954 — microbiology — Posted on 2021-01-02
4159 Orchestration of the stilbene synthase gene family and their regulators by subgroup 2 MYB genes
Orduna, L.; Li, M.; Navarro, D.; Zhang, C.; Ramsak, Z.; Gruden, K.; Höll, J.; Merz, P.; Vannozzi, A.; Cantu, D.; Bogs, J.; Wong, D. C. J.; Huang, S.-s. C.; Matus, J. T.
10.1101/2020.12.31.424746 — plant biology — Posted on 2021-01-02
4162 Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction
Subramanian, S.; Gorday, K.; Marcus, K.; Orellana, M. R.; Ren, P.; Luo, X. R.; O'Donnell, M. E.; Kuriyan, J.
10.1101/2020.12.31.424921 — biophysics — Posted on 2021-01-02
4166 Knowledge graph analytics platform with LINCS and IDG for Parkinson's disease target illumination
Yang, J. J.; Gessner, C. R.; Duerksen, J. L.; Biber, D.; Binder, J. L.; Ozturk, M.; Foote, B.; McEntire, R.; Stirling, K.; Ding, Y.; Wild, D. J.
10.1101/2020.12.30.424881 — bioinformatics — Posted on 2021-01-02
4167 Comprehensive analysis of the host-virus interactome of SARS-CoV-2
Chen, Z.; Wang, C.; Feng, X.; Nie, L.; Tang, M.; Zhang, H.; Xiong, Y.; Swisher, S. K.; Srivastava, M.; Chen, J.
10.1101/2020.12.31.424961 — molecular biology — Posted on 2021-01-02
4169 Sequencing of Sars-CoV-2 genome using different Nanopore chemistries
Gonzalez-Recio, O.; Gutierrez-Rivas, M.; Peiro-Pastor, R.; Aguilera-Sepulveda, P.; Cano-Gomez, C.; Jimenez-Clavero, M. A.; Fernandez-Pinero, J.
10.1101/2021.01.02.425072 — microbiology — Posted on 2021-01-02
4171 The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates
Li, D.; Edwards, R. J.; Manne, K.; Martinez, D. R.; Schafer, A.; Alam, S. M.; Wiehe, K.; Lu, X.; Parks, R.; Sutherland, L. L.; Oguin, T. H.; McDanal, C.; Perez, L. G.; Mansouri, K.; Gobeil, S. M. C.; Janowska, K.; Stalls, V.; Kopp, M.; Cai, F.; Lee, E.; Foulger, A.; Hernandez, G.; Sanzone, A.; Tilahun, K.; Jiang, C.; Tse, L. V.; Bock, K. W.; Minai, M.; Nagata, B. M.; Cronin, K.; Gee-Lai, V.; Deyton, M.; Barr, M.; Von Holle, T.; Macintyre, A. N.; Stover, E.; Feldman, J.; Hauser, B. M.; Caradonna, T. M.; Scobey, T. D.; Moody, M. A.; Cain, D. W.; DeMarco, C. T.; Denny, T. N.; Woods, C. W.; Petzol
10.1101/2020.12.31.424729 — immunology — Posted on 2021-01-02
4172 Precise genomic deletions using paired prime editing
Choi, J.; Chen, W.; Suiter, C. C.; Lee, C.; Chardon, F. M.; Yang, W.; Leith, A.; Daza, R. M.; Martin, B.; Shendure, J.
10.1101/2020.12.30.424891 — bioengineering — Posted on 2021-01-02
4175 Function of the HYDROXYCINNAMOYL-CoA:SHIKIMATE HYDROXYCINNAMOYL TRANSFERASE is evolutionarily conserved in embryophytes
Kriegshauser, L.; Knosp, S.; Grienenberger, E.; Tatsumi, K.; Gütle, D. D.; Sorensen, I.; Herrgott, L.; Zumsteg, J.; Rose, J. K. C.; Reski, R.; Werck, D.; Renault, H.
10.1101/2020.09.16.300285 — plant biology — Posted on 2021-01-02
4182 PEDF and Derived Peptides Prevent Apoptosis and Promote Differentiation of Retinal Photoreceptors
Michelis, G.; German, O. L.; Villasmil, R.; Rotstein, N. P.; Politi, L.; Becerra, S. P.
10.1101/2021.01.01.425044 — cell biology — Posted on 2021-01-01
4184 Bulkhead-like apical membrane structures between hepatocytes are required for anisotropic lumen expansion and liver tissue morphogenesis
Belicova, L.; Repnik, U.; Delpierre, J.; Gralinska, E.; Seifert, S.; Valenzuela, J. I.; Morales-Navarrete, H. A.; Franke, C.; Raagel, H.; Shcherbinina, E.; Prikazchikova, T. P.; Koteliansky, V.; Vingron, M.; Kalaidzidis, Y.; Zatsepin, T.; Zerial, M.
10.1101/2020.12.31.424978 — cell biology — Posted on 2021-01-01
4187 A persistent invasive phenotype in post-hypoxic tumor cells is revealed by novel fate-mapping and computational modeling
Rocha, H. L.; Godet, I.; Kurtoglu, F.; Metzcar, J.; Konstantinopoulos, K.; Bhoyar, S.; Gilkes, D. M.; Macklin, P.
10.1101/2020.12.30.424757 — cancer biology — Posted on 2021-01-01
4188 A Constitutively Closed Pannexin1 Channel in Lipid Bilayer Nanodiscs Assembles as a Large-Pore Heptamer
Jin, X.; Leonhardt, S. A.; Chiu, Y.-H.; Purdy, M. D.; McIntire, W. E.; Bennett, B. C.; Bayliss, D. A.; Yeager, M.
10.1101/2020.12.31.425019 — biophysics — Posted on 2021-01-01
4189 Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses
Banchenko, S.; Krupp, F.; Gotthold, C.; Buerger, J.; Graziadei, A.; O' Reilly, F.; Sinn, L.; Ruda, O.; Rappsilber, J.; Spahn, C. M. T.; Mielke, T.; Taylor, I. A.; Schwefel, D.
10.1101/2020.12.31.424931 — biochemistry — Posted on 2021-01-01
4190 Simultaneous Identification of Brain Cell Type and Lineage via Single Cell RNA Sequencing
Anderson, D. J.; Pauler, F.; McKenna, A.; Shendure, J.; Hippenmeyer, S.; Horwitz, M. S.
10.1101/2020.12.31.425016 — genomics — Posted on 2021-01-01
4192 Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution
Trevino, A. E.; Muller, F.; Andersen, J.; Sundaram, L.; Kathiria, A.; Shcherbina, A.; Farh, K.; Chang, H. Y.; Pasca, A. M.; Kundaje, A.; Pasca, S. P.; Greenleaf, W. J.
10.1101/2020.12.29.424636 — neuroscience — Posted on 2021-01-01
4193 A Hot-Coal theory of Working Memory
Lundqvist, M.; Rose, J.; Warden, M. R.; Buschman, T. J.; Miller, E. K.; Herman, P.
10.1101/2020.12.30.424833 — neuroscience — Posted on 2021-01-01
4195 CO2 signalling mediates neurovascular coupling in the cerebral cortex
Hosford, P. S.; Wells, J. A.; Ruminot, I.; Christie, I. N.; Theparambil, S. M.; Hadjihambi, A.; Barros, L. F.; Lythgoe, M. F.; Gourine, A. V.
10.1101/2020.12.31.424942 — neuroscience — Posted on 2021-01-01
4197 The gastrin-releasing peptide regulates stress-enhanced fear and dopamine signaling
Morishita, Y.; Fuentes, I.; Favate, J.; Zushida, K.; Nishi, A.; Hevi, C.; Goldsmith, N.; Buyske, S.; Sillivan, S. E.; Miller, C. A.; Kandel, E. R.; Uchida, S.; Shah, P.; Shumyatsky, G. P.
10.1101/2020.12.31.424996 — neuroscience — Posted on 2021-01-01
4198 A genome-scale yeast library with inducible expression of individual genes
Arita, Y.; Kim, G.; Li, Z.; Friesen, H.; Turco, G.; Wang, R. Y.; Climie, D.; Usaj, M.; Hotz, M.; Stoops, E.; Baryshnikova, A.; Boone, C.; Botstein, D.; Andrews, B. J.; McIsaac, R. S.
10.1101/2020.12.30.424776 — synthetic biology — Posted on 2021-01-01
4200 Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models
de Rus Jacquet, A.; Ambaw, A.; Tambe, M. A.; Timmers, M.; Ma, S. Y.; Wu, Q.-L.; Simon, J. E.; McCabe, G. P.; Lila, M. A.; Shi, R.; Rochet, J.-C.
10.1101/2020.12.01.391268 — pharmacology and toxicology — Posted on 2021-01-01
4203 MiREDiBase: a manually curated database of validated and putative editing events in microRNAs
Marceca, G. P.; Distefano, R.; Tomasello, L.; Lagana, A.; Russo, F.; Calore, F.; Romano, G.; Bagnoli, M.; Gasparini, P.; Ferro, A.; Acunzo, M.; Ma, Q.; Croce, C. M.; Nigita, G.
10.1101/2020.09.04.283689 — bioinformatics — Posted on 2021-01-01
4204 Quantitative Genetic Scoring, or how to put a number on an arbitrary genetic region
Schoenmacker, G. H.; Vlaming, P.; Pallesen, J.; Pikulina, M. Y.; Ghamarian, A. H.; Demontis, D. H.; Borglum, A.; Galesloot, T. E.; Poelmans, G.; Franke, B.; Claassen, T.; Heskes, T.; Buitelaar, J.; Arias Vasquez, A.
10.1101/2020.12.15.422886 — bioinformatics — Posted on 2021-01-01
4205 X-MOL: large-scale pre-training for molecular understanding and diverse molecular analysis
Xue, D.; Zhang, H.; Xiao, D.; Gong, Y.; Chuai, G.; Sun, Y.; Tian, H.; Wu, H.; Li, Y.; Liu, Q.
10.1101/2020.12.23.424259 — bioinformatics — Posted on 2021-01-01
4206 Clipper: p-value-free FDR control on high-throughput data from two conditions
Ge, X.; Chen, Y. E.; Song, D.; McDermott, M.; Woyshner, K.; Manousopoulou, A.; Wang, L. D.; Li, W.; Li, J. J.
10.1101/2020.11.19.390773 — bioinformatics — Posted on 2021-01-01
4209 Assembly and Validation of Two Gap-free Reference Genomes for Xian/indica Rice Reveals Insights into Plant Centromere Architecture
Song, J.-M.; Xie, W.-Z.; Wang, S.; Guo, Y.-X.; Koo, D.-H.; Kudrna, D.; Huang, Y.; Feng, J.-W.; Zhang, W.; Zhou, Y.; Zuccolo, A.; Long, E.; Lee, S.; Talag, J.; Zhou, R.; Zhu, X.-T.; Yuan, D.; Udall, J.; Xie, W.; Wing, R. A.; Zhang, Q.; Poland, J.; Zhang, J.; Chen, L.-L.
10.1101/2020.12.24.424073 — genomics — Posted on 2021-01-01
4211 Leveraging the Mendelian Disorders of the Epigenetic Machinery to Systematically Map Functional Epigenetic Variation
Luperchio, T. R.; Boukas, L.; Zhang, L.; Pilarowski, G. O.; Jiang, J.; Kalinousky, A.; Hansen, K. D.; Bjornsson, H. T.
10.1101/2020.11.08.373456 — genetics — Posted on 2021-01-01
4214 A morphological trait involved in reproductive isolation between Drosophila sister species is sensitive to temperature
Peluffo, A. E.; Hamdani, M.; Vargas-Valderrama, A.; David, J. R.; Mallard, F.; Graner, F.; Courtier-Orgogozo, V.
10.1101/2020.01.20.911826 — evolutionary biology — Posted on 2021-01-01
4216 Comparing statistical and mechanistic models to identify the drivers of mortality within a rear-edge beech population
Petit-Cailleux, C.; Davi, H.; Lefevre, F.; Garrigue, J.; Magdalou, J.-A.; Hurson, C.; Magnanou, E.; Muratorio, S.
10.1101/645747 — ecology — Posted on 2021-01-01
4217 Impacts of water quality on Acropora coral settlement: The relative importance of substrate quality and light
Ricardo, G. F.; Harper, C. E.; Negri, A. P.; Luter, H. M.; Abdul Wahab, M. A.; Jones, R. J.
10.1101/2020.11.19.390724 — ecology — Posted on 2021-01-01
4218 scATAC-Seq reveals epigenetic heterogeneity associated with an EMT-like process in male germline stem cells and its regulation by G9a
Liao, J.; Suen, H. C.; Luk, A. C. S.; Lee, A. W. T.; Ng, J. K. W.; Chan, T. H. T.; Cheung, M. Y.; Chan, D. Y. L.; Qi, H.; Chan, W.-Y.; Hobbs, R. M.; Lee, T. L.
10.1101/2020.10.12.336834 — cell biology — Posted on 2021-01-01
4219 DNA damage activates mTORC1 signaling in podocytes leading to glomerulosclerosis
Braun, F.; Blomberg, L.; Akbar-Hase, R. A.; Puelles, V. G.; Wong, M. N.; Rahmatollahi, M.; Fermin, D.; Slaats, G.; Koehler, S.; Brinkkoetter, P.; Lindenmeyer, M. T.; Cohen, C.; Kann, M.; Bloch, W.; Sampson, M. G.; Huber, T. B.; Schermer, B.; Benzing, T.; Schumacher, B.; Kurschat, C. E.
10.1101/2020.09.13.295303 — cell biology — Posted on 2021-01-01
4220 The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion.
Oliver, S. L.; Xing, Y.; Chen, D.-H.; Roh, S. H.; Pintilie, G. D.; Bushnell, D. A.; Sommer, M. H.; Yang, E.; Carfi, A.; Chiu, W.; Arvin, A. M.
10.1101/2020.09.08.269191 — microbiology — Posted on 2021-01-01
4225 Control of neurogenic competence in mammalian hypothalamic tanycytes.
Yoo, S.; Kim, J.; Lyu, P.; Hoang, T.; Ma, A.; Trinh, V.; Dai, W.; Jiang, L.; Leavey, P.; Won, J.-K.; Park, S.-H.; Qian, J.; Brown, S. P.; Blackshaw, S.
10.1101/2020.11.02.359992 — neuroscience — Posted on 2021-01-01
4227 Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system
Jablonski, L.; Harczos, T.; Wolf, B.; Hoch, G.; Dieter, A.; Hessler, R.; Ayub, S.; Ruther, P.; Moser, T.
10.1101/2020.05.25.114868 — neuroscience — Posted on 2021-01-01
4229 Systems Biology under heat stress in Indian Cattle
Khan, R. I. N.; Sahu, A. R.; Malla, W. A.; Praharaj, M. R.; Hosamani, N.; Kumar, S.; Gupta, S.; Sharma, S.; Saxena, A.; Varshney, A.; Singh, P.; Verma, V.; Kumar, P.; Singh, G.; Pandey, A.; Saxena, S.; Gandham, R. K.; Tiwari, A. K.
10.1101/2020.04.09.031153 — physiology — Posted on 2021-01-01
4230 Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation
Martin, E. W.; Thomasen, F. E.; Milkovic, N. M.; Cuneo, M. J.; Grace, C. R.; Nourse, A.; Lindorff-Larsen, K.; Mittag, T.
10.1101/2020.05.15.096966 — biophysics — Posted on 2021-01-01
4231 Removing unwanted variation between samples in Hi-C experiments
Fletez-Brant, K.; Qiu, Y.; Gorkin, D. U.; Hu, M.; Hansen, K. D.
10.1101/214361 — genomics — Posted on 2021-01-01
4232 All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity
Severin, D.; Hong, S. Z.; Roh, S.-E.; Zhou, J.; Bridi, M. C. D.; Murase, S.; Robertson, S.; Haberman, R.; Huganir, R.; Gallaghe, M.; Quinlan, E. M.; Worley, P.; kirkwood, a.
10.1101/2020.12.30.424871 — neuroscience — Posted on 2021-01-01
4235 Allosteric communication in Class A β-lactamases occurs via Cooperative Coupling of Loop Dynamics
Galdadas, I.; Qu, S.; Oliveira, A. S. F.; Olehnovics, E.; Mack, A. R.; Mojica, M. F.; Agarwal, P. K.; Tooke, C. L.; Gervasio, F. L.; Spencer, J.; Bonomo, R. A.; Mulholland, A. J.; Haider, S.
10.1101/2020.12.30.424904 — biophysics — Posted on 2021-01-01
4240 Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients
Huang, Y.; Sun, B.; Debarros, J.; Zhang, C.; Zhan, S.; Li, D.; Zhang, C.; Wang, T.; Huang, P.; Lai, Y.; Brown, P.; Cao, C.; Tan, H.
10.1101/2020.12.30.424800 — neuroscience — Posted on 2021-01-01
4241 Mechanical Stretch Inhibition SensitizesProprioceptors to Compressive Stresses
Das, R.; Lin, L.-C.; Catala-Castro, F.; Malaiwong, N.; Sanfeliu, N.; Porta-de-la-Riva, M.; Pidde, A.; Krieg, M.
10.1101/2020.12.30.422571 — neuroscience — Posted on 2021-01-01
4249 Pan-cancer analysis of mRNA stability for decoding tumour post-transcriptional programs
Perron, G.; Jandaghi, P.; Rajaee, M.; Alkallas, R.; Riazalhosseini, Y.; Najafabadi, H. S.
10.1101/2020.12.30.424872 — genomics — Posted on 2021-01-01
4250 Drosophila functional screening of de novo variants in autism uncovers deleterious variants and facilitates discovery of rare neurodevelopmental diseases
Marcogliese, P. C.; Deal, S. L.; Andrews, J.; Harnish, J. M.; Bhavana, V. H.; Graves, H. K.; Jangam, S.; Luo, X.; Liu, N.; Bei, D.; Chao, Y.-H.; Hull, B.; Lee, P.-T.; Pan, H.; Longley, C. M.; Chao, H.-T.; Chung, H.; Haelterman, N. A.; Kanca, O.; Manivannan, S. N.; Rossetti, L. Z.; Gerard, A.; Schwaibold, E. M. C.; Guerrini, R.; Vetro, A.; England, E.; Murali, C. N.; Barakat, T. S.; van Dooren, M. F.; Wilke, M.; van Slegtenhorst, M.; Lesca, G.; Sabatier, I.; Chatron, N.; Brownstein, C. A.; Madden, J. A.; Agrawal, P. B.; Keller, R.; Pavinato, L.; Brusco, A.; Rosenfeld, J. A.; Marom, R.; Wangler,
10.1101/2020.12.30.424813 — genetics — Posted on 2021-01-01
4251 Fatty acid metabolic reprogramming promotes C. elegans development
Cao, X.; Xie, Y.; Xue, B.; Yang, H.; Garcia, L. R.; Zhang, L.
10.1101/2020.12.30.424804 — genetics — Posted on 2021-01-01
4253 The structural basis for Ulp2 recruitment to the kinetochore
Quan, Y.; Hinshaw, S. M.; Wang, P.-C.; Harrison, S. C.; Zhou, H.
10.1101/2020.12.30.424835 — cell biology — Posted on 2021-01-01
4254 Integrative analysis reveals unique features of the Smc5/6 complex
Yu, Y.; Li, S.; Ser, Z.; Sanyal, T.; Choi, K.; Wan, B.; Sali, A.; Kentsis, A.; Patel, D. J.; Zhao, X.
10.1101/2020.12.31.424863 — molecular biology — Posted on 2021-01-01
4256 Bovine neutrophils release extracellular traps and cooperate with macrophages in Mycobacterium avium subsp. paratuberculosis clearance
Ladero-Aunon, I.; Molina, E.; Holder, A.; Kolakowski, J.; Harris, H.; Urkitza, A.; Anguita, J.; Werling, D.; Elguezabal, N.
10.1101/2020.12.30.424791 — immunology — Posted on 2021-01-01
4257 Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques
Wood, M. P.; Jones, C. I.; Lippy, A.; Oliver, B. G.; Walund, B.; Fancher, K. A.; Fisher, B. S.; Wright, P. J.; Fuller, J. T.; Murapa, P.; Habib, J.; Mavigner, M.; Chahroudi, A.; Sather, D. N.; Fuller, D. H.; Sodora, D.
10.1101/2020.12.31.424784 — immunology — Posted on 2021-01-01
4258 Simultaneous inhibition of human CD4 and 4-1BB biogenesis suppresses cytotoxic T lymphocyte proliferation
Claeys, E.; Pauwels, E.; Humblet-Baron, S.; Schols, D.; Waer, M.; Sprangers, B.; Vermeire, K.
10.1101/2020.12.30.424816 — immunology — Posted on 2021-01-01