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Archive, 2022-09

4 Neural representations of the content and production of human vocalization
Voigtlaender, V. A.; Sandhaeger, F.; Hawellek, D.; Hage, S. R.; Siegel, M.
10.1101/2022.09.30.510259 — neuroscience — Posted on 2022-09-30
6 Accelerated signal propagation speed in human neocortical microcircuits
Olah, G.; Lakovics, R.; Shapira, S.; Leibner, Y.; Szucs, A.; Barzo, P.; Molnar, G.; Segev, I.; Tamas, G.
10.1101/2022.09.30.510270 — neuroscience — Posted on 2022-09-30
9 ATM-Mediated Double-Strand Break Repair Is Required for Meiotic Genome Stability at High Temperature
Zhao, J.; Gui, X.; Ren, Z.; Fu, H.; Yang, C.; Liu, Q.; Zhang, M.; Wang, W.; Wang, C.; Schnittger, A.; Liu, B.
10.1101/2022.09.29.510164 — plant biology — Posted on 2022-09-30
12 Proteomic Mapping of Intercellular Synaptic Environments via Flavin-Dependent Photoredox Catalysis
Bechtel, T. J.; Bertoch, J. M.; Olow, A. K.; Duich, M.; White, C. H.; Reyes-Robles, T.; Fadeyi, O. O.; Oslund, R. C.
10.1101/2022.09.29.510150 — biochemistry — Posted on 2022-09-30
13 Single cell evaluation of endocardial HAND2 gene regulatory networks reveals critical HAND2 dependent pathways impacting cardiac morphogenesis.
George, R. M.; Firulli, B. A.; Podicheti, R.; Rusch, D. B.; Mannion, B. J.; Pennacchio, L. A.; Osterwalder, M.; Firulli, A. B.
10.1101/2022.09.29.510167 — developmental biology — Posted on 2022-09-30
14 Antimicrobial Resistance, Genomic, and Public Health Insights into Enterococcus spp. from Australian Cattle
Sahibzada, S.; Abraham, R. J.; Lee, T.; Jordan, D.; McMillan, K.; Mellor, G. E.; Duffy, L. L.; O'Dea, M.; Abraham, S.; Barlow, R. S.
10.1101/2022.09.29.510230 — microbiology — Posted on 2022-09-30
15 Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor
Mahalingam, G.; Arjunan, P.; Periasami, Y.; Dhyani, A. K.; Devaraju, N.; Rajendiran, V.; Christopher, A. C.; KT, R. D.; Darasingh, I.; Thangavel, S.; Murugesan, M.; Moorthy, M.; Srivastava, A.; Marepally, S.
10.1101/2022.09.30.510287 — pharmacology and toxicology — Posted on 2022-09-30
16 Loss of ZNF251 stimulates NHEJ resulting in PARP inhibitor resistance in BRCA1-mutated cancer cells
Li, H.; Chatla, S.; Liu, X.; Walt, M.; Kim, D.; Lian, Z.; Morton, G.; Feng, Z.; Yang, D.; Liu, H.; Sullivan-Reed, K.; Childers, W.; Yu, X.; Madzo, J.; Chitrala, K. N.; Skorski, T.; Huang, J.
10.1101/2022.09.29.510119 — cancer biology — Posted on 2022-09-30
19 Genomic accordions may hold the key to Monkeypox Clade IIb's increased transmissibility
Monzon, S.; Varona, S.; Negredo, A.; Patino-Galindo, J. A.; Vidal-Freire, S.; Zaballos, A.; Orviz, E.; Ayerdi, O.; Munoz-Garcia, A.; Delgado-Iribarren, A.; Estrada, V.; Garcia, C.; Molero, F.; Sanchez, P.; Torres, M.; Vazquez, A.; Galan, J.-C.; Torres, I.; Causse del Rio, M.; Merino, L.; Lopez, M.; Galar, A.; Cardenoso, L.; Gutierrez, A.; Camacho, J.; Herrero, L.; Jimenez-Sancho, P.; Navarro-Rico, M. L.; Jado, I.; Kuhn, J.; Sanchez-Lockhart, M.; Di Paola, N.; Kugelman, J. R.; Giannetti, E.; Guerra, S.; Garcia-Sastre, A.; Palacios, G.; Sanchez-Seco, M.; Cuesta, I.
10.1101/2022.09.30.510261 — genomics — Posted on 2022-09-30
20 Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape
Marzi, R.; Bassi, J.; Silacci-Fregni, C.; Bartha, I.; Muoio, F.; Culap, K.; Sprugasci, N.; Lombardo, G.; Saliba, C.; Cameroni, E.; Cassotta, A.; Low, J. S.; Walls, A. C.; McCallum, M.; Tortorici, M. A.; Bowen, J. E.; Dellota, E. A.; Dillen, J. R.; Czudnochowski, N.; Pertusini, L.; Terrot, T.; Lepori, V.; Tarkowski, M.; Riva, A.; Biggiogero, M.; Franzetti Pellanda, A.; Garzoni, C.; Ferrari, P.; Ceschi, A.; Giannini, O.; Havenar-Daughton, C.; Telenti, A.; Arvin, A.; Virgin, H. W.; Sallusto, F.; Veesler, D.; Lanzavecchia, A.; Corti, D.; Piccoli, L.
10.1101/2022.09.30.509852 — immunology — Posted on 2022-09-30
21 More than half of the variance in in-vivo 1H-MRS metabolite estimates is common to all metabolites
Prisciandaro, J. J.; Zöllner, H. J.; Murali-Manohar, S.; Oeltzschner, G.; Edden, R. A. E.
10.1101/2022.09.29.510115 — neuroscience — Posted on 2022-09-30
22 Technical insights into fluorescence lifetime microscopy of mechanosensitive Flipper probes
Roffay, C.; Garcia Arcos, J. M.; Chapuis, P.; Lopez-Andarias, J.; Colom, A.; Tomba, C.; Di Meglio, I.; Matile, S.; Roux, A.; Mercier, V.
10.1101/2022.09.28.509885 — biophysics — Posted on 2022-09-30
24 Brief Report: Prognostic relevance of 3q amplification in squamous cell carcinoma of the lung
Abu Rous, F.; Li, P.; Carskadon, S.; Singh, S. R.; Chacko, R.; Abushukair, H.; Gadgeel, S.; Palanisamy, N.
10.1101/2022.09.28.509728 — genomics — Posted on 2022-09-30
25 Meta-analysis of GWAS for sea lice load in Atlantic salmon
Caceres, P. A.; Lopez, P.; Garcia, B.; Cichero, D.; Odegard, J.; Moen, T.; Yanez, J.
10.1101/2022.09.28.509902 — genomics — Posted on 2022-09-30
26 Distribution of sex ratio distorters in natural populations of the isopod Armadillidium vulgare
Durand, S.; Lheraud, B.; Giraud, I.; Bech, N.; Grandjean, F.; Rigaud, T.; Peccoud, J.; Cordaux, R.
10.1101/2022.09.29.510044 — evolutionary biology — Posted on 2022-09-30
30 Heritage of ancient cultures supports conservation: a continent-wide perspective from the Eurasian steppes
Deak, B.; Bede, A.; Radai, Z.; Dembicz, I.; Apostolova, I.; Batary, P.; Galle, R.; Toth, C. A.; Dozsai, J.; Moysiyenko, I. I.; Sudnik-Wojcikowska, B.; Nekhrizov, G.; Lisetskii, F. N.; Buryak, Z. A.; Kis, S.; Borza, S.; Godo, L.; Bragina, T. M.; Smelansky, I.; Molnar, A.; Ban, M.; Bathori, F.; Argay, Z.; Dani, J.; Valko, O.
10.1101/2022.09.29.510067 — ecology — Posted on 2022-09-30
31 Drivers and implications of the extreme 2022 wildfire season in Southwest Europe
RODRIGUES, M.; CUNILL CAMPRUBI, A.; BALAGUER-ROMANO, R.; RUFFAULT, J.; FERNANDES, P.; Resco de Dios, V.
10.1101/2022.09.29.510113 — ecology — Posted on 2022-09-30
34 Diagnosis of type 2 Diabetes Mellitus (T2DM) using Paired microRNAs
Takada, Y.; Ono, Y.; Shibuta, T.; Ishibashi, A.; Takamori, A.; Fujimoto, K.; Hirooka, Y.; Umemura, T.
10.1101/2022.09.29.510072 — molecular biology — Posted on 2022-09-30
39 Detection of orthologous genes with expression shifts linked to nickel hyperaccumulation across Eudicots
Gallopin, M.; Drevet, C.; Garcia de la Torre, V. S.; Jelassi, S.; Michel, M.; Ducos, C.; Saule, C.; Majorel, C.; Burtet-Sarramegna, V.; Pillon, Y.; Bastide, P.; Lespinet, O.; MERLOT, S.
10.1101/2022.09.28.509953 — plant biology — Posted on 2022-09-30
41 Tetraose glycoalkaloids from potato can provide complete protection against fungi and insects
Wolters, P. J.; Wouters, D.; Tikunov, Y. M.; Ayilalath, S.; Kodde, L. P.; Strijker, M.; Caarls, L.; Visser, R. G. F.; Vleeshouwers, V. G. A. A.
10.1101/2022.09.28.509958 — plant biology — Posted on 2022-09-30
42 Subchronic oral toxicity study of Aldicarb sulfoxide in Sprague-Dawley rats
Yongchao, J.; Yi, L.; Juanjuan, D.; Yiting, W.; Yu, W.; Fan, W.; Chao, C.; Wensheng, Z.
10.1101/2022.09.29.510057 — pharmacology and toxicology — Posted on 2022-09-30
44 A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma
Noonan, H. R.; Barbano, J.; Xifaras, M.; Baron, C. S.; Yang, S.; Koczirka, K.; McConnell, A. M.; Zon, L. I.
10.1101/2022.09.29.510035 — cancer biology — Posted on 2022-09-30
45 Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer
Titmarsh, H. F.; von Kriegsheim, A.; Wills, J. C.; O'Connor, R. A.; Dhaliwal, K.; Frame, M. C.; Pattle, S. B.; Dorward, D. A.; Byron, A.; Akram, A. R.
10.1101/2022.09.29.510064 — cancer biology — Posted on 2022-09-30
47 Discovery of E6AP AZUL binding to UBQLN1/2 in cells, phase-separated droplets, and an AlphaFold-NMR integrated structure
Buel, G. R.; Chen, X.; Myint, W.; Kayode, O.; Folimonova, V.; Cruz, A.; Skorupka, K.; Matsuo, H.; Walters, K.
10.1101/2022.09.29.510132 — biophysics — Posted on 2022-09-30
54 Predicting partner fitness based on spatial structuring in a light-driven microbial community
Sakkos, J. K.; Santos-Merino, M.; Kokarakis, E. J.; Li, B.; Fuentes-Cabrera, M.; Zuliani, P.; Ducat, D. C.
10.1101/2022.09.28.510001 — bioengineering — Posted on 2022-09-30
57 A high quality chromosome-level genome assembly for the golden mussel (Limnoperna fortunei)
Rodinho Nunes Ferreira, J. G.; Americo, J. A.; Amaral, D. L. A. S.; Sendim, F.; da Cunha, Y. R.; The Darwin Tree of Life Project Consortium, ; Uliano-Silva, M.; Rebelo, M. d. F.
10.1101/2022.09.29.509984 — genomics — Posted on 2022-09-30
59 Large-scale assessment of habitat quality and quantity change on declining European butterflies
Chazot, N.; Faurby, S.; van Swaay, C.; Ekroos, J.; Wahlberg, N.; Bacon, C. D.; Antonelli, A.
10.1101/2022.09.29.510048 — ecology — Posted on 2022-09-30
60 Clarifying space use concepts in ecology: range vs. occurrence distributions
Alston, J. M.; Fleming, C. H.; Noonan, M. J.; Tucker, M. A.; Silva, I.; Folta, C.; Akre, T. S.; Ali, A. H.; Belant, J. L.; Beyer, D.; Blaum, N.; Boehning-Gaese, K.; Cunha de Paula, R.; Dekker, J.; Drescher-Lehman, J.; Farwig, N.; Fichtel, C.; Fischer, C.; Ford, A. T.; Janssen, R.; Jeltsch, F.; Kappeler, P. M.; LaPoint, S. D.; Markham, A. C.; Medici, P.; Morato, R. G.; Nathan, R.; Olson, K.; Patterson, B. D.; Petroelje, T.; Ramalho, E. E.; Roesner, S.; Santos, L. G. R. O.; Schabo, D. G.; Selva, N.; Sergiel, A.; Spiegel, O.; Ullman, W.; Zieba, F.; Zwijacz-Kozica, T.; Wittemyer, G.; Fagan, W. F.;
10.1101/2022.09.29.509951 — ecology — Posted on 2022-09-30
62 Cellular Factors Involved in Transcriptome Dynamics in Early Zebrafish Embryogenesis
Rauwerda, H.; Pagano, J. F. B.; de Leeuw, W. C.; Ensink, W.; van Olst, M.; Nehrdich, U.; Jonker, M. J.; Spaink, H. P.; Breit, T. M.
10.1101/2022.09.29.510050 — developmental biology — Posted on 2022-09-30
63 Lineage segregation in human pre-implantation embryos is specified by YAP1 and TEAD1
Regin, M.; Essahib, W.; Demtschenko, A.; Dewandre, D.; David, L.; Gerri, C.; Niakan, K.; Verheyen, G.; Tournaye, H.; Sterckx, J.; Sermon, K.; Van de Velde, H.
10.1101/2022.09.29.509946 — developmental biology — Posted on 2022-09-30
65 Methotrexate inhibition of muropeptide transporter SLC46A2 controls psoriatic skin inflammation
Bharadwaj, R.; Lusi, C. F.; Mashayekh, S.; Nagar, A.; Malireddi, R. K. S.; Kane, G. I.; Wodzanowski, K.; Brown, A.; Okuda, K.; Monahan, A.; Paik, D.; Nandy, A.; Anonick, M.; Goldman, W. E.; Kanneganti, T.-D.; Orzalli, M. H.; Grimes, C. L.; Atukorale, P. U.; Silverman, N.
10.1101/2022.09.29.509906 — immunology — Posted on 2022-09-30
68 MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control
Heiland, M.; Connolly, N. M. C.; Nguyen, N. T.; Kesavan, J. C.; Fanning, K.; Sanfeliu, A.; Yan, Y.; Veno, M. T.; Costard, L. S.; Neubert, V.; Hill, T. D. M.; Rosenow, F.; Bauer, S.; Kjems, J.; Morris, G.; Henshall, D.
10.1101/2022.09.29.510105 — neuroscience — Posted on 2022-09-30
69 Dopamine regulates decision thresholds in human reinforcement learning.
Chakroun, K.; Wiehler, A.; Wagner, B.; Mathar, D.; Ganzer, F.; vanEimeren, T.; Sommer, T.; Peters, J.
10.1101/2022.09.29.509499 — neuroscience — Posted on 2022-09-30
70 Phosphatidylserine controls synaptic targeting and membrane stability of ASIC1a
Liu, D.-S.; Song, X.-L.; Liu, M.-G.; Lu, J.; Huang, Y.; Jeon, J.; Ma, G.; Li, Y.; Pozzo-Miller, L.; Zhu, M. X.; Xu, T.-L.
10.1101/2022.09.29.509830 — neuroscience — Posted on 2022-09-30
73 Synapsing with oligodendrocyte precursor cells stop sensory axons regenerating into the spinal cord
Kim, H.; Skuba, A.; Xia, J.; Han, S. B.; Zhai, J.; Yoo, R.; Hu, H.; Kang, S. H.; Son, Y.-J.
10.1101/2022.09.28.509944 — neuroscience — Posted on 2022-09-30
74 Brain-wide associations between white matter and agehighlight the role of fornix microstructure in brain age
Korbmacher, M.; de Lange, A. M.; van der Meer, D.; Beck, D.; Eikefjord, E. N.; Lundervold, A.; Andreassen, O.; Westlye, L. T.; Maximov, I. I.
10.1101/2022.09.29.510029 — neuroscience — Posted on 2022-09-30
75 Low-dimensional organization of global brain states of reduced consciousness
Perl, Y. S.; Pallavicini, C.; Piccinini, J.; Demertzi, A.; Bonhomme, V.; Martial, C.; Panda, R.; Alnagger, N.; Annen, J.; Gosseries, O.; Ibanez, A.; Laufs, H.; Sitt, J.; Jirsa, V.; Kringelbach, M. L.; Laureys, S.; Deco, G.; Tagliazucchi, E.
10.1101/2022.09.28.509817 — neuroscience — Posted on 2022-09-30
80 Multi-modal digital pathology for colorectal cancer diagnosis by high-plex immunofluorescence imaging and traditional histology of the same tissue section
Lin, J.-R.; Chen, Y.-A.; Campton, D.; Cooper, J.; Coy, S.; Yapp, C.; Tefft, J.; McCarty, E.; Ligon, K.; Rodig, S. J.; Reese, S.; George, T.; Santagata, S.; Sorger, P. K.
10.1101/2022.09.28.509927 — cancer biology — Posted on 2022-09-30
81 Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers In Vivo
Magoling, B. J. A.; Chen, Y.-J.; Wu, A. Y.-T.; Wong, W. W.-T.; Chuo, S. T.-Y.; Huang, H.-C.; Sung, Y.-C.; Hsieh, H.-T.; Huang, P.; Lee, K.-Z.; Huang, K.-W.; Chen, R.-H.; Chen, Y.; Lai, C. P.
10.1101/2022.09.28.510006 — cancer biology — Posted on 2022-09-30
82 Aberrant DNA repair is a vulnerability in histone H3.3-mutant brain tumors
Rondinelli, B.; Giacomini, G.; Piquet, S.; Chevallier, O.; Dabin, J.; Bai, S.-K.; Kim, B.; Siddaway, R.; Raught, B.; Coyaud, E.; Shan, C.-M.; Reid, R. J. D.; Toda, T.; Rothstein, R.; Wilhelm, T.; Barra, V.; Crane, A.; Dubois, F.; Bandopadhayay, P.; Beroukhim, R.; Naim, V.; Jia, S.; Hawkins, C.; Polo, S. E.
10.1101/2022.09.29.510093 — cancer biology — Posted on 2022-09-30
83 A NOVEL UNBIASED SEED-BASED RNAi SCREEN IDENTIFIES SMALL RNAs THAT INHIBIT ANDROGEN SIGNALING AND PROSTATE CANCER CELL GROWTH
Corbin, J. M.; Georgescu, C.; Wang, L.; Wren, J. D.; Bieniasz, M.; Xu, C.; Asch, A. S.; Ruiz Echevarria, M. J.
10.1101/2022.09.29.510140 — cancer biology — Posted on 2022-09-30
85 LKB1 loss rewires JNK-induced apoptotic protein dynamics through NUAKs and sensitizes KRAS-mutant NSCLC to combined KRASG12C + MCL-1 blockade
Li, C.; Syed, M. U.; Shen, Y.; Fraser, C.; Ouyang, J.; Kreuzer, J.; Clark, S. E.; Oh, A.; Walcott, M.; Morris, R.; Nabel, C.; Caenepeel, S.; Saiki, A. Y.; Rex, K.; Lipford, J. R.; Heist, R. S.; Lin, J. J.; Haas, W.; Sarosiek, K.; Hughes, P. E.; Hata, A. N.
10.1101/2022.09.29.510137 — cancer biology — Posted on 2022-09-30
87 Emergent chirality in active solid rotation of pancreas spheres
Tan, T. H.; Amiri, A.; Seijo-Barandiaran, I.; Staddon, M. F.; Materne, A.; Tomas, S.; Duclut, C.; Popovic, M.; Grapin-Botton, A.; Jülicher, F.
10.1101/2022.09.29.510101 — biophysics — Posted on 2022-09-30
89 Mass spectrometry of RNA-binding proteins during liquid-liquid phase separation reveals distinct assembly mechanisms and droplet architectures
Sahin, C.; Motso, A.; Gu, X.; Feyrer, H.; Lama, D.; Arndt, T.; Rising, A.; Gese, G. V.; Hällberg, B. M.; Marklund, E. G.; Schafer, N. P.; Petzold, K.; Teilum, K.; Wolynes, P. G.; Landreh, M.
10.1101/2022.09.28.509878 — biophysics — Posted on 2022-09-30
91 Single-particle tracking and machine-learning classification reveals heterogeneous Piezo1 diffusion
Tyagi, V.; Ly, A. T.; Bertaccini, G. A.; Evans, E. L.; Freites, J. A.; Tobias, D. J.; Pathak, M. M.
10.1101/2022.09.30.510193 — biophysics — Posted on 2022-09-30
94 Multiomics reveal that silk fibroin and sericin differentially potentiate the paracrine functions of mesenchymal stem cells and enhance tissue regeneration
Zhang, Y.; Sheng, R.; Chen, J.; Wang, H.; Zhu, Y.; Cao, Z.; Zhao, X.; Wang, Z.; Liu, C.; Chen, Z.; Zhang, P.; Kuang, B.; Zheng, H.; Yao, Q.; Zhang, W.
10.1101/2022.09.29.510013 — bioengineering — Posted on 2022-09-30
95 Genetically Encoded RNA-based Bioluminescence Resonance Energy Transfer (BRET) Sensors
Mi, L.; Yu, Q.; Mudiyanselage, A. P. K. K. K.; Wu, R.; Sun, Z.; Zheng, R.; Ren, K.; You, M.
10.1101/2022.09.28.509942 — bioengineering — Posted on 2022-09-30
96 Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectors
Westhaus, A.; Cabanes-Creus, M.; Dilworth, K. L.; Zhu, E.; Salas Gomez, D.; Navarro, R. G.; Amaya, A. K.; Scott, S.; Kwiatek, M.; McCorkindale, A. L.; Hayman, T. E.; Frahm, S.; Perocheau, D. P.; Tran, B. M.; Vincan, E.; Wong, S. L.; Waters, S. A.; Wilson, L. O. W.; Baruteau, J.; Diecke, S.; Gonzalez-Aseguinolaza, G.; Santilli, G.; Thrasher, A. J.; Alexander, I. E.; Lisowski, L.
10.1101/2022.09.28.510021 — bioengineering — Posted on 2022-09-30
97 Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP
Yeager, C.; Carter, G.; Gohara, D. W.; Yennawar, N. H.; Enemark, E. J.; Arnold, J. J.; Cameron, C. E.
10.1101/2022.09.28.509975 — biochemistry — Posted on 2022-09-30
98 Nanoscale Friction of Model Hair Surfaces
Weiand, E.; Ewen, J. P.; Roiter, Y.; Koenig, P. H.; Page, S. H.; Rodriquez-Ropero, F.; Angioletti-Uberti, S.; Dini, D.
10.1101/2022.09.29.510078 — biochemistry — Posted on 2022-09-30
100 Parental pericentromeric methylation status drives methylome remodelling and heterosis in epigenetic hybrids
Kakoulidou, I.; Piecyk, R. S.; Meyer, R. C.; Kuhlmann, M.; Altmann, T.; Gutjahr, C.; Johannes, F.
10.1101/2022.09.29.510107 — genomics — Posted on 2022-09-30
107 Coinfection with chytrid genotypes drives divergent infection dynamics reflecting broad epidemiological patterns
Carvalho, T.; Medina, D.; Ribeiro, L. P.; Rodriguez, D.; Jenkinson, T. S.; Becker, G.; Toledo, L. F.; Hite, J.
10.1101/2022.09.28.509987 — ecology — Posted on 2022-09-30
114 Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endothelium
Ghersi, J. J.; Baldissera, g.; Hintzen, J.; Luff, S. A.; Cheng, S.; Xia, I. F.; Sturgeon, C. M.; Nicoli, S.
10.1101/2022.09.28.509963 — developmental biology — Posted on 2022-09-30
115 Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay
Overeem, A. W.; Chang, Y. W.; Moustakas, I.; Roelse, C. M.; Hillenius, S.; van der Helm, T.; van der Schrier, V. F.; Mei, H.; Freund, C.; Chuva de Sousa Lopes, S. M.
10.1101/2022.09.28.509976 — developmental biology — Posted on 2022-09-30
118 Circadian regulation of protein turnover and proteome renewal
Seinkmane, E.; Peak-Chew, S. Y.; Zeng, A.; Rzechorzek, N. M.; Beale, A. D.; Wong, D. C.; O'Neill, J. S.
10.1101/2022.09.30.509905 — cell biology — Posted on 2022-09-30
119 YAP1 is essential for self-organized differentiation of pluripotent stem cells
Zeevaert, K.; Goetzke, R.; Elsafi Mabrouk, M. H.; Schmidt, M.; Maassen, C.; Henneke, A.-C.; He, C.; Gillner, A.; Zenke, M.; Wagner, W.
10.1101/2022.09.29.510043 — cell biology — Posted on 2022-09-30
121 30-Minute Highly Multiplexed VaxArray Immunoassay for Pneumococcal Vaccine Antigen Characterization
Hu, T.; Miller, D. F.; Taylor, A. W.; McCormick, C.; Thomas, K. N.; Gao, R. Y.; Rowlen, K.; Kim, S. K.; Byrne, E. B.; Kumar, P.; Riley, C.; Dawson, E. D.
10.1101/2022.09.28.509947 — immunology — Posted on 2022-09-30
122 Metabolic plasticity of T-cell therapies: multi-omic profiling of interacting human tumor-infiltrating lymphocytes and autologous tumor adoptive cell therapy
Martinez-Paniagua, M.; Haymaker, C.; Robinson, J.; Harel, M.; Creasy, C.; Adolacion, J. R. T.; An, X.; Fathi, M.; Rezvan, A.; Kumar, M.; Amritkar, A.; Woodman, S. E.; Amaria, R. N.; Geiger, T.; Hwu, P.; Bernatchez, C.; Varadarajan, N.
10.1101/2022.09.28.509590 — immunology — Posted on 2022-09-30
123 Cross-reactive single-domain antibodies to hemagglutinin stem region protect mice from group 1 influenza A virus infection
Voronina, D. V.; Bandelyuk, A. S.; Dzharullaeva, A. S.; Popova, O.; Kan, V. Y.; Esmagambetov, I. B.; Favorskaya, I. A.; Shcheblyakov, D. V.; Naroditskiy, B. S.; Gintsburg, A. L.
10.1101/2022.09.29.510074 — immunology — Posted on 2022-09-30
127 The BeMoBIL Pipeline for automated analyses of multimodal mobile brain and body imaging data
Klug, M.; Jeung, S.; Wunderlich, A.; Gehrke, L.; Protzak, J.; Djebbara, Z.; Argubi-Wollesen, A.; Wollesen, B.; Gramann, K.
10.1101/2022.09.29.510051 — neuroscience — Posted on 2022-09-30
130 kcna1a mutant zebrafish as a model of episodic ataxia type 1 and epilepsy
Dogra, D.; Meza-Santoscoy, P. L.; Rehak, R.; de la Hoz, C. L. R.; Gavrilovici, C.; Ibhazehiebo, K.; Rho, J. M.; Kurrasch, D. M.
10.1101/2022.09.28.509973 — neuroscience — Posted on 2022-09-30
131 Accurate Bayesian segmentation of thalamic nuclei using diffusion MRI and an improved histological atlas
Tregidgo, H. F. J.; Soskic, S.; Althonayan, J.; Maffei, C.; Van Leemput, K.; Golland, P.; Yendiki, A.; Alexander, D. C.; Bocchetta, M.; Rohrer, J. D.; Iglesias, J. E.
10.1101/2022.09.28.508731 — neuroscience — Posted on 2022-09-30
132 Electrophile scanning by chemical proteomics reveals a potent pan-active DUB probe for investigation of deubiquitinase activity in live cells
Conole, D. P.; Cao, F.; Am Ende, C. W.; Xue, L.; Kantesaria, S.; Kang, D.; Jin, J.; Owen, D. P.; Lohr, L. L.; Schenone, M.; Majmudar, J. D.; Tate, E. W.
10.1101/2022.09.28.509970 — systems biology — Posted on 2022-09-30
138 Type 1 interferon remodels normal and neoplastic hematopoiesis in human
Lama, C.; Rosenberg, S.; Kubas-Meyer, A.; Xie, X. A.; Moein, S.; Parghi, N.; Totwani, M.; Saurty-Seerunghen, M. S.; Omar, M.; Dillard, A.; Omans, N. D.; Dusaj, N. N.; Chamely, P.; Mimitou, E.; Smibert, P.; Kosiorek, H. E.; Dueck, A. C.; Weinberg, R.; Chaligne, R.; Marchionni, L.; Patel, S.; Simonson, P. D.; Landau, D. A.; Hoffman, R.; Nam, A. S.
10.1101/2022.09.28.509751 — cancer biology — Posted on 2022-09-30
139 Small Molecule Assembly Modulators with Pan-Cancer Therapeutic Efficacy
Lingappa, A. F.; Akintunde, O.; Ewald, C.; Froehlich, M.; Ziari, N.; Yu, S. F.; Michon, M.; Mallesh, S.; Lin, J.; Kitaygorodskyy, A.; Solas, D.; Reed, J. C.; Lingappa, J. R.; Mueller-Schiffmann, A.; Korth, C.; Prasad, M. D.; Ashton, E.; Fabbri, B.; Nalca, A.; Petrouski, E.; Dey, D.; Andrews, D. W.; Lingappa, V. R.
10.1101/2022.09.28.509937 — cancer biology — Posted on 2022-09-30
147 Temperature-triggered in situ forming lipid mesophase gel for local treatment of ulcerative colitis
Carone, M.; Spalinger, M. R.; Gaultney, R. A.; Mookhoek, A.; Krebs, P.; Rogler, G.; Luciani, P.; Aleandri, S.
10.1101/2022.09.28.509483 — bioengineering — Posted on 2022-09-30
150 A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brains
Sziraki, A.; Lu, Z.; Lee, J.; Banyai, G.; Anderson, S.; Abdulraouf, A.; Metzner, E.; Liao, A.; Epstein, A.; Xu, Z.; Zhang, Z.; Gan, L.; Nelson, P. T.; Zhou, W.; Cao, J.
10.1101/2022.09.28.509825 — genomics — Posted on 2022-09-30
152 Selection and adaptive introgression guided the complex evolutionary history of European common bean
Bellucci, E.; Benazzo, A.; Xu, C.; Bitocchi, E.; Rodriguez, M.; Alseekh, S.; Di Vittori, V.; Gioia, T.; Neumann, K.; Cortinovis, G.; Frascarelli, G.; Murube, E.; Trucchi, E.; Nanni, L.; Ariani, A.; Logozzo, G.; Shin, J. H.; Liu, C.; Jiang, L.; Ferreira, J. J.; Campa, A.; Attene, G.; Morrell, P. L.; Bertorelle, G.; Graner, A.; Gepts, P.; Fernie, A. R.; Jackson, S. A.; Papa, R.
10.1101/2022.09.28.509856 — genomics — Posted on 2022-09-30
160 Wildflower phenological escape differs by continent and spring temperature
Lee, B. R.; Miller, T.; Rosche, C.; Yang, Y.; Heberling, J. M.; Kuebbing, S. E.; Primack, R. B.
10.1101/2022.09.28.509910 — ecology — Posted on 2022-09-30
161 Accelerated High-throughput Plant Imaging and Phenotyping System
Kose, T.; Lins, T. F.; Wang, J.; O'Brien, A. M.; Sinton, D.; Frederickson, M. E.
10.1101/2022.09.28.509964 — ecology — Posted on 2022-09-30
165 Stress vesicles are induced by acute mechanical force and precede the commitment of epidermal stem cells to terminal differentiation
Huang, S.; Kuri, P.; Zou, J.; Blanco, A.; Marshall, M.; Rice, G.; Prouty, S.; Dentchev, T.; Doepner, M.; Boerckel, J. D.; Capell, B.; Ridky, T. W.; Rompolas, P.
10.1101/2022.09.29.510204 — cell biology — Posted on 2022-09-30
166 Nazo, the Drosophila homolog of the NBIA-mutated protein - c19orf12, is required for triglyceride homeostasis
Sreejith, P.; Lolo, S.; Patten, K. R.; Gunasinghe, M.; More, N.; Pallanck, L. J.; Bharadwaj, R.
10.1101/2022.09.29.510106 — cell biology — Posted on 2022-09-30
167 mTOR inhibitor-independent Autophagy Activator Ameliorates Cellular Tauopathy and Prionopathy Neurodegeneration Phenotypes
Yoon, L.; Botham, R. C.; Verhelle, A.; Cole, C.; Tan, E. P.; Wu, Y.; Sanz-Martinez, P.; Xu, J.; Cuoco, C. A.; Chou, C. C.; Labra, S.; Elia, L. P.; Massey, L. A.; Lee, K.; Xiao, Q.; Kline, G. M.; Ta, A.; Ardejani, M. S.; Cano-Franco, S.; Lyang, N. J.; Hou, W. C.; Yu, A.; Fox, S.; Ko, Y.; Chen, W.; Wulkop-Gil, C.; Ibrahim, L. H.; Jiang, S.; Meneses, A.; Nelson, L. T.; Peng, H.; Lipton, S. A.; Bollong, M. J.; Hansen, M.; Morimoto, R. I.; Finley, D.; Petrassi, H. M.; Wiseman, R. L.; Powers, E. T.; Finkbeiner, S.; Garza, D.; Prado, M. A.; Dikic, I.; Frydman, J.; Johnson, K. A.; Silva, M. C.; Haggar
10.1101/2022.09.29.509997 — cell biology — Posted on 2022-09-30
168 Single-cell sequencing identifies novel atypical B cell subsets with distinct effector functions
Reyes, R. A.; Batugedara, G.; Dutta, P.; Reers, A.; Garza, R.; Ssewanyana, I.; Feeney, M. E.; Greenhouse, B.; Bol, S.; Bunnik, E. M.
10.1101/2022.09.28.509955 — immunology — Posted on 2022-09-30
169 Value-Based Neural Representations Predict Social Decision Preferences
Guassi Moreira, J. F.; Mendez Leal, A. S.; Waizman, Y. H.; Tashjian, S. M.; Galvan, A.; Silvers, J. A.
10.1101/2022.09.28.509596 — neuroscience — Posted on 2022-09-30
170 A Simple Model of Cortical Intraregional Metastability
Venkadesh, S.; Shaikh, A.; Shakeri, H.; Henry, T. R.; Barreto, E.; Van Horn, J. D.
10.1101/2022.09.28.509893 — neuroscience — Posted on 2022-09-30
175 Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia.
Godet, A.-C.; Roussel, E.; David, F.; Hantelys, F.; Morfoisse, F.; Alves, J.; Pujol, F.; Ader, I.; Bertrand, E.; Burlet-Schiltz, O.; Froment, C.; Henras, A.; Vitali, P.; Lacazette, E.; Tatin, F.; Garmy-Susini, B.; Prats, A.-C.
10.1101/2021.02.10.430272 — molecular biology — Posted on 2022-09-30
176 The effects of combined action observation and motor imagery on corticospinal excitability and movement outcomes: Two meta-analyses
Chye, S.; Chembila Valappil, A.; Wright, D. J.; Frank, C.; Shearer, D. A.; Tyler, C. J.; Diss, C. E.; Mian, O.; Tillin, N.; Bruton, A. M.
10.1101/2022.05.23.493106 — neuroscience — Posted on 2022-09-30
178 Diets affect the age-dependent decline of associative learning in Caenorhabditis elegans
Higurashi, S.; Tsukada, S.; Aleogho, B. M.; Park, J. H.; Tanaka, M.; Nakano, S.; Mori, I.; Noma, K.
10.1101/2020.10.08.331256 — neuroscience — Posted on 2022-09-30
179 A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta
Carter, B.; Huang, P.; Liu, G.; Liang, Y.; Lin, P. J. C.; Peng, B.-H.; McKay, L.; Dimitrakakis, A.; Hsu, J.; Tat, V.; Saenkham-Huntsinger, P.; Chen, J.; Kaseke, C.; Gaiha, G. D.; Xu, Q.; Griffiths, A.; Tam, Y. K.; Tseng, C.-T. K.; Gifford, D. K.
10.1101/2022.09.23.509206 — immunology — Posted on 2022-09-30
180 Cellular proteomic profiling using proximity labelling by TurboID-NES in microglial and neuronal cell lines.
Sunna, S.; Bowen, C.; Zeng, H.; Rayaprolu, S.; Kumar, P.; Bagchi, P.; Guo, Q.; Duong, D. M.; Bitarafan, S.; Natu, A.; Wood, L.; Seyfried, N. T.; Rangaraju, S.
10.1101/2022.09.27.509765 — neuroscience — Posted on 2022-09-30
182 Molecular Dynamics Simulations of Ion Permeation in human NaV Channels
Alberini, G.; Paz, S. A.; Corradi, B.; Abrams, C.; Benfenati, F.; Maragliano, L.
10.1101/2022.09.29.509656 — biophysics — Posted on 2022-09-30
186 The sulfonylpiperazine MMV020291 prevents red blood cell invasion by the malaria parasite Plasmodium falciparum through interference with actin-1/profilin dynamics
Dans, M. G.; Piirainen, H.; Nguyen, W.; Khurana, S.; Mehra, S.; Razook, Z.; Das, S.; Parkyn Schneider, M.; Jonsdottir, T. K.; Gabriela, M.; Gancheva, M. R.; Tonkin, C. J.; Mollard, V.; Goodman, C. D.; McFadden, G. I.; Wilson, D. W.; Barry, A. E.; Crabb, B. S.; de Koning-Ward, T. F.; Sleebs, B. E.; Kursula, I.; Gilson, P. R.
10.1101/2022.09.29.510018 — molecular biology — Posted on 2022-09-30
187 SIRT1 regulates DNA damage signaling through the PP4phosphatase complex
Rasti, G.; Becker, M.; Vazquez, B. N.; Espinosa-Alcantud, M.; Fernandez-Duran, I.; Gamez-Garcia, A.; Gonzalez-Nieto, J.; Bosch-Presegue, L.; Marazuela-Duque, A.; Segura-Bayona, S.; Ianni, A.; Bech-Serra, J.-J.; Scher, M.; Serrano, L.; Shankavaram, U.; Erdjument-Bromage, H.; Tempst, P.; Reinberg, D.; Olivella, M.; Stracker, T.; de la Torre, C.; Vaquero, A.
10.1101/2022.09.29.510108 — molecular biology — Posted on 2022-09-30
188 Towards environmental detection, quantification, and molecular characterization of Anopheles stephensi and Aedes aegypti from larval breeding sites
Kristan, M.; Acford-Palmer, H.; Campos, M. O.; Collins, E.; Phelan, J.; Portwood, N.; Pelloquin, B.; Clarke, S.; Lines, J.; Clark, T. G.; Walker, T.; Campino, S. G.; Messenger, L. A.
10.1101/2022.09.29.510135 — molecular biology — Posted on 2022-09-30
189 Expanded diversity of tfdA harboring bacteria across the natural and built environment
White, A. M.; Gonzalez Vazquez, A.; McDaniel, E. A.; Peterson, B. D.; Koch, P. L.; Remucal, C. K.; McMahon, K. D.
10.1101/2022.09.28.509959 — microbiology — Posted on 2022-09-30
190 Characterisation of an Escherichia coli line that completely lacks ribonucleotide reduction yields insights into the evolution of obligate intracellularity.
Arras, S. D. M.; Sibaeva, N.; Catchpole, R. J.; Horinouchi, N.; Si, D.; Rickerby, A. M.; Deguchi, K.; Hibi, M.; Tanaka, K.; Takeuchi, M.; Ogawa, J.; Poole, A. M.
10.1101/2022.09.28.509999 — microbiology — Posted on 2022-09-30
196 Pathway elucidation of pharmaceutical cucurbitacin IIa in Hemsleya chinensis and high-level production of precursor cucurbitadienol in engineered Saccharomyces cerevisiae and Nicotiana benthamiana
Hao, B.; Chen, G.; Guo, Z.-k.; Zhao, Y.; Shu, Y.-y.; Qiu, L.; Duan, S.-f.; Lin, Y.; He, S.-m.; Li, X.-b.; Feng, X.-L.; Xiang, G.-s.; Shi, Y.; Yang, S.-C.; Zhang, G.-H.
10.1101/2022.09.28.509966 — synthetic biology — Posted on 2022-09-30
197 In situ targeted mutagenesis of gut bacteria
Brodel, A. K.; Charpenay, L.; Galtier, M.; Fuche, F. J.; Terrasse, R.; Poquet, C.; Arraou, M.; Prevot, G.; Spadoni, D.; Hessel, E. M.; Fernandez-Rodriguez, J.; Duportet, X.; Bikard, D.
10.1101/2022.09.30.509847 — synthetic biology — Posted on 2022-09-30
198 Diversity, Equity, and Inclusion in the Melanoma Research Community
Portuallo, M. E.; Lu, D. Y.; Alicea, G. M.; Bolling, J.; Lee, R.; McQuade, J.; Warner, A. B.; Davies, M.; Weeraratna, A.; Villanueva, J.; Rebecca, V. W.
10.1101/2022.09.24.509278 — scientific communication and education — Posted on 2022-09-30
203 Reduced Cdc14 phosphatase activity impairs septation, hyphal differentiation and pathogenesis and causes echinocandin hypersensitivity in Candida albicans
Milholland, K. L.; AbdelKhalek, A.; Baker, K. M.; Hoda, S.; DeMarco, A. G.; Naughton, N. H.; Koeberlein, A. N.; Lorenz, G. R.; Anandasothy, K.; Esperilla-Munoz, A.; Narayanan, S. K.; Correa-Bordes, J.; Briggs, S. D.; Hall, M. C.
10.1101/2022.09.29.510203 — molecular biology — Posted on 2022-09-30
204 Single-nucleus RNA-seq reveals that MBD5, MBD6, and SILENZIO maintain silencing during epigenetic reprogramming in pollen
Ichino, L.; Picard, C. L.; Yun, J.; Chotai, M.; Wang, S.; Lin, E. K.; Papareddy, R. K.; Xue, Y.; Jacobsen, S. E.
10.1101/2022.09.29.510154 — molecular biology — Posted on 2022-09-30
205 Microbiota-dependent histone butyrylation in the mammalian intestine
Gates, L. A.; Reis, B. S.; Lund, P. J.; Paul, M. R.; Leboeuf, M.; Nadeem, Z.; Carroll, T. S.; Garcia, B.; Mucida, D.; Allis, C. D.
10.1101/2022.09.29.510184 — molecular biology — Posted on 2022-09-30
206 Early season soil microbiome best predicts wheat grain quality
Asad, N. I.; Wang, X.; Dozois, J. A.; Azarbad, H.; Constant, P.; Yergeau, E.
10.1101/2022.09.29.510160 — microbiology — Posted on 2022-09-30
207 A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites
Zhang, X.; Florini, F.; Visone, J. E.; Leonardi, I.; Gross, M. R.; Patel, V.; Deitsch, K. W.
10.1101/2022.09.29.510131 — microbiology — Posted on 2022-09-30
209 Production of selenium nanoparticles occurs through an interconnected pathway of sulfur metabolism and oxidative stress response in Pseudomonas putida KT2440
Avendano, R.; Munoz-Montero, S.; Rojas-Gätjens, D.; Fuentes, P.; Vieto, S.; Montenegro, R.; Salvador, M.; Frew, R.; Kim, J.; Chavarria, M.; Jimenez, J. I.
10.1101/2022.09.29.507446 — microbiology — Posted on 2022-09-30
210 Modulation of the functional interfaces between retroviral intasomes and the human nucleosome
Mauro, E.; Lapaillerie, D.; Tumiotto, C.; Charlier, C.; Martins, F.; Sousa, S.; Metifiot, M.; Weigel, P.; Yamatsugu, K.; Kanai, M.; Lehmann, H.; Richetta, C.; Batisse, J.; Ruff, M.; Delelis, O.; Paul, L.; Parissi, V.
10.1101/2022.09.29.510092 — microbiology — Posted on 2022-09-30
211 The paradoxical relationship between CRISPR-Cas and phage susceptibility in Pseudomonas aeruginosa
Lood, C.; Verkinderen, E.; Petrovic Fabijan, A.; Iredell, J. R.; Ceyssens, P.-J.; van Noort, V.; Lavigne, R.
10.1101/2022.09.29.510058 — microbiology — Posted on 2022-09-30
212 Exploring dose-response relationships in Aedes aegypti survival upon bacteria and arbovirus infection.
Rocha, M. M.; Talyuli, O. A. C.; Costa, C. L. R.; Granella, L. W.; Mansur, D. S.; Oliveira, P. L.; Oliveira, J. H. M.
10.1101/2022.09.29.510144 — microbiology — Posted on 2022-09-30
213 Atmospheric nitrogen fixation by eukaryotes: Should we reconsider the nitrogen cycle in nature?
Arapitsas, N.; Christakis, C. A.; Angelakis, G.; Maragkoudakis, A.; Kotzabasis, K.; Sarris, P. F.
10.1101/2022.09.29.510055 — microbiology — Posted on 2022-09-30
214 Mycelial differentiation linked avermectin production in studied with Raman imaging
Horii, S.; Samuel, A. Z.; Nakashima, T.; Take, A.; Matsumoto, A.; Takahashi, Y.; Ando, M.; Takeyama, H.
10.1101/2022.09.30.508653 — microbiology — Posted on 2022-09-30
217 Loss of Rab8a in B cells leads to increased antibody responses and class-switch recombination
Hernandez-Perez, S.; Sarapulov, A. V.; Balci, M. O.; Coffey, E.; Harada, A.; Mattila, P.
10.1101/2022.09.19.508414 — immunology — Posted on 2022-09-30
221 AGO1 and HSP90 buffer different genetic variants in Arabidopsis thaliana
Lemus, T.; Mason, G. A.; Bubb, K. L.; Alexandre, C. M.; Queitsch, C.; Cuperus, J. T.
10.1101/2022.06.27.497824 — plant biology — Posted on 2022-09-30
223 Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of the mitochondrial protease LONP1
Mo, A. Y.-C.; Kincross, H.; Wang, X.; Chang, L. Y.-T.; Duns, G.; Kwan, H.; Lau, T.; Docking, T. R.; Tran, J.; Colborne, S.; Cheng, S.-W. G.; Huang, S.; Gharaee, N.; Willie, E.; Jiang, J.; Parker, J.; Bridgers, J.; Wood, D.; Klein Geltink, R.; Morin, G. B.; Karsan, A.
10.1101/2022.09.10.507366 — cancer biology — Posted on 2022-09-30
225 Frequent spontaneous structural rearrangements promote rapid genome diversification in a Brassica napus F1 generation
Orantes-Bonilla, M.; Makhoul, M.; Lee, H.; Singh Chawla, H.; Vollrath, P.; Langstroff, A.; Sedlazeck, F. J.; Zou, J.; Snowdon, R. J.
10.1101/2022.06.27.497715 — genomics — Posted on 2022-09-30
229 A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates
He, P.; Lim, K.; Sun, D.; Pett, J. P.; Jeng, Q.; Polanski, K.; Dong, Z.; Bolt, L.; Richardson, L.; Mamanova, L.; Dabrowska, M.; Wilbrey-Clark, A. L.; Madissoon, E.; Tuong, K. Z.; Dann, E.; Suo, C.; Goh, I.; Yoshida, M.; Nikolic, M. Z.; James, S. M.; He, X.; Barker, R. A.; Teichmann, S.; Marioni, J.; Meyer, K. B.; Rawlins, E. L.
10.1101/2022.01.11.474933 — developmental biology — Posted on 2022-09-30
230 MR1 dependent MAIT cell activation is regulated by autophagy associated proteins
Phalora, P.; Ussher, J. E.; Hester, S.; Marchi, E.; Mak, J. Y. W.; Fairlie, D. P.; Klenerman, P.
10.1101/2022.09.20.508788 — cell biology — Posted on 2022-09-30
232 A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
dos Reis, T. F.; de Castro, P. A.; Bastos, R.; Pinzan, C. F.; Souza, P. F.; Ackloo, S.; Hossain, M. A.; Drewry, D.; Alkhazraji, S.; Ibrahim, A.; Jo, H.; deGrado, W. F.; Goldman, G.
10.1101/2022.09.28.509882 — microbiology — Posted on 2022-09-30
234 AAV-delivered gene editing for latent genital or orofacial herpes simplex virus infection reduces ganglionic viral load and minimizes subsequent viral shedding in mice
Aubert, M.; Haick, A. K.; Strongin, D. E.; Klouser, L. M.; Loprieno, M. A.; Stensland, L.; Santo, T. K.; Huang, M.-l.; Hyrien, O.; Stone, D.; Jerome, K. R.
10.1101/2022.09.23.509057 — neuroscience — Posted on 2022-09-30
235 Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce a symmetric gait
Lu, Y.; Ahamed, T.; Mulcahy, B.; Witvliet, D.; Guan, S. A.; Holmyard, D.; Hung, W.; Meng, J.; Wen, Q.; Chisholm, A.; Samuel, A.; Zhen, M.
10.1101/2021.09.21.461278 — neuroscience — Posted on 2022-09-30
239 Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation
Aggarwal, G.; Banerjee, S.; Jones, S. A.; Benchaar, Y.; Belanger, J.; Sevigny, M.; Smith, D. M.; Niehoff, M. L.; Pavlack, M. D.; de Vera, I. M. S.; Petkau, T. L.; Leavitt, B. R.; Ling, K.; Jafar-Nejad, P.; Rigo, F. D.; Morley, J. E.; Farr, S. A.; Dutchak, P. A.; Sephton, C. F.; Nguyen, A. D.
10.1101/2022.01.12.476053 — neuroscience — Posted on 2022-09-30
240 A scalable screening platform for phenotypic subtyping of ALS patient-derived fibroblasts
Kumbier, K.; Roth, M.; Li, Z.; Lazzari-Dean, J.; Waters, C.; Huang, P.; Korobeynikov, V.; ALS Consortium, N. Y. G. C.; Phatnani, H.; Shneider, N.; Jacobson, M. P.; Wu, L.; Altschuler, S.
10.1101/2022.09.27.509770 — systems biology — Posted on 2022-09-30
241 TMEM100, a Lung-Specific Endothelium Gene
Liu, B.; Yi, D.; Yu, Z.; Pan, J.; Ramirez, K.; Li, S.; Wang, T.; Glembotski, C.; Fallon, M.; Oh, P.; Gu, M.; Kalucka, J.; Dai, Z.
10.1101/2022.08.26.504609 — physiology — Posted on 2022-09-30
242 Dehydration alters transcript levels in the mosquito midgut, likely facilitating rapid rehydration
Holmes, C. J.; Brown, E. S.; Sharma, D.; Warden, M.; Pathak, A.; Payton, B.; Nguyen, Q.; Spangler, A.; Sivakumar, J.; Hendershot, J. M.; Benoit, J. B.
10.1101/2022.09.15.508146 — physiology — Posted on 2022-09-30
244 The biomechanical context influences the PI3K output sig-naling in breast and pancreatic cancer cells.
Di-Luoffo, M.; Schmitter, C.; Barrere, E.; Therville, N.; Delarue, M.; Guillermet-Guibert, J.
10.1101/2021.10.18.464825 — cancer biology — Posted on 2022-09-30
245 IRF7 impacts on prostate cancer cell survival in response to radiation
Pickard, A.; Amoroso, F.; McCulloch, K.; Erickson, A.; Sachdeva, A.; Steele, R.; Mukherjee, D.; Dellett, M.; McComb, J.; McCaffrey, L.; Hart, C.; Brown, M.; McDade, S. S.; Waugh, D.; Clarke, N.; Butterworth, K.; Illidge, T.; Mirtti, T.; Overton, I. M.; Mills, I.
10.1101/2022.09.23.509205 — cancer biology — Posted on 2022-09-30
246 Phenotyping Polarization Dynamics Of Immune Cells Using A Lipid Droplet - Cell Pairing Microfluidic Platform
Pinon, L.; Ruyssen, N.; Pineau, J.; Mesdjian, O.; Cuvelier, D.; Chipont, A.; Allena, R.; Guerin, C.; Asnacios, S.; Asnacios, A.; Pierobon, P.; Fattaccioli, J.
10.1101/2021.12.22.473360 — biophysics — Posted on 2022-09-30
249 FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells
Warren, I. T.; Guiggey, D.; Chiang, A.; Maloy, M. H.; Ogoke, O.; Groth, T. S.; Mon, T.; Meamardoost, S.; Liu, X.; Thompson, S.; Szeglowski, A.; Thompson, R.; Chen, P.; Paulmurugan, R.; Yarmush, M. L.; Kidambi, S.; Parashurama, N.
10.1101/2020.06.01.128108 — bioengineering — Posted on 2022-09-30
250 Computational investigation of IP3 diffusion
Ornelas Guevara, R.; Gil, D.; Voorsluijs, V.; Dupont, G.
10.1101/2022.08.19.504488 — biochemistry — Posted on 2022-09-30
251 Dosage sensitivity in Pumilio1-related phenotypes reflects distinct disease mechanisms
Botta, S.; de Prisco, N.; Chemiakine, A.; Cabaj, M.; Patel, P.; Doron-Mandel, E.; Treadway, C. J.; Jovanovic, M.; Brown, N. G.; Soni, R. K.; Gennarino, V. A.
10.1101/2021.03.11.435015 — genetics — Posted on 2022-09-30
252 Genetic Regulators of Sputum Mucin Concentration and Their Associations with COPD Phenotypes
Van Buren, E.; Radicioni, G.; Lester, S.; O'Neal, W.; Dang, H.; Kasela, S.; Gardadri, S.; Curtis, J.; Han, M.; Krishnan, J.; Wan, E.; Silverman, E.; Hastie, A.; Ortega, V.; Lappalainen, T.; Christenson, S.; Li, Y.; Cho, M.; Kesimer, M.; Kelada, S.
10.1101/2022.09.28.509838 — genetics — Posted on 2022-09-30
254 Restrained activation of CYFIP2-containing WAVE complexes controls membrane protrusions and cell migration
Polesskaya, A.; Boutillon, A.; Yang, S.; Wang, Y.; Romero, S.; Liu, Y.; Lavielle, M.; Molinie, N.; Rocques, N.; Fokin, A.; Guerois, R.; Chen, B.; David, N. B.; Gautreau, A. M.
10.1101/2020.07.02.184655 — cell biology — Posted on 2022-09-30
255 Extracellular caspase-1 regulates hair follicle stem cell migration during wound-healing
Ghosh, S.; Hegde, A.; Ananthan, A. S.; Kataria, S.; Pincha, N.; Dutta, A.; Dutta, A.; Athreya, S.; Khedkar, S. U.; Dey, R.; Bhosale, A.; Jamora, C.
10.1101/548529 — cell biology — Posted on 2022-09-30
259 EPAC1 Inhibition Protects the Heart from Doxorubicin-Induced Toxicity
Mazevet, M.; Belhadef, A.; Ribeiro, M.; Dayde, D.; Llach, A.; Laudette, M.; Belleville, T.; Mateo, P.; Gressette, M.; Lefebvre, F.; Chen, J.; Bachelot-Loza, C.; Rucker-Martin, C.; Lezoualch, F.; Crozatier, B.; Benitah, J.-P.; Vozenin, M.-C.; Fischmeister, R.; Gomez, A.-M.; Lemaire, C.; Morel, E.
10.1101/2021.06.16.448655 — pathology — Posted on 2022-09-30
260 Moving beyond MARCO
Rosa, N.; Watkins, C. J.; Newman, J. M.
10.1101/2022.09.28.509867 — biophysics — Posted on 2022-09-30
261 Polygenic scoring accuracy varies across the genetic ancestry continuum in all human populations
Ding, Y.; Hou, K.; Xu, Z.; Pimplaskar, A.; Petter, E.; Boulier, K.; Prive, F.; Vilhjalmsson, B. J.; Loohuis, L. O.; Pasaniuc, B.
10.1101/2022.09.28.509988 — genetics — Posted on 2022-09-29
266 Accurate and efficient constrained molecular dynamics of polymers through Newton's method and special purpose code
Lopez-Villellas, L.; Kjelgaard Mikkelsen, C. C.; Galano-Frutos, J. J.; Marco-Sola, S.; Alastruey-Benede, J.; Ibanez, P.; Moreto, M.; Sancho, J.; Garcia-Risueno, P.
10.1101/2022.09.28.509839 — molecular biology — Posted on 2022-09-29
268 Single molecule imaging and modelling of mRNA decay dynamics in the Drosophila embryo
Forbes Beadle, L.; Love, J. C.; Shapovalova, Y.; Artemev, A.; Rattray, M.; Ashe, H. L.
10.1101/2022.03.17.484585 — developmental biology — Posted on 2022-09-29
269 Sensitivity of diffusion-tensor and correlated diffusion imaging to white-matter microstructural abnormalities: application in COVID-19
Teller, N.; Chad, J. A.; Wong, A.; Gunraj, H.; Ji, X.; MacIntosh, B. J.; Roudaia, E.; Gilboa, A.; Lam, B.; Sekuler, A.; Heyn, C.; Graham, S.; Black, S.; Chen, J. J.
10.1101/2022.09.29.510004 — biophysics — Posted on 2022-09-29
270 A linear SARS-CoV-2 DNA vaccine candidate reduces virus shedding in ferrets
Martins, M.; do Nascimento, G. M.; Conforti, A.; Noll, J. C. G.; Impellizeri, J. A.; Sanches, E.; Wagner, B.; Lione, L.; Salvatori, E.; Pinto, E.; Compagnone, M.; Viscount, B.; Hayward, J.; Shorrock, C.; Aurisicchio, L.; Diel, D. G.
10.1101/2022.09.29.510112 — immunology — Posted on 2022-09-29
271 Rich dynamics and functional organization on topographically designed neuronal networks in vitro
Montala-Flaquer, M.; Lopez-Leon, C. F.; Tornero, D.; Houben, A. M.; Fardet, T.; Monceau, P.; Bottani, S.; Soriano, J.
10.1101/2022.09.28.509646 — bioengineering — Posted on 2022-09-29
274 Cortical somatostatin interneuron subtypes form cell-type specific circuits
Wu, J. S.; Sevier, E.; Saldi, G.-A.; Yu, S.; Abbott, L.; Choi, D. H.; Sherer, M.; Qiu, Y.; Shinde, A.; Rizzo, D.; Xu, Q.; Barrera, I.; Kumar, V.; Marrero, G.; Pörnneke, A.; Huang, S.; Rudy, B.; Stafford, D. A.; Macosko, E.; Chen, F.; Fishell, G.
10.1101/2022.09.29.510081 — neuroscience — Posted on 2022-09-29
276 Meta-analysis refinement of plasma extracellular vesicle composition identifies proplatelet basic protein as a signaling messenger in type 1 diabetes
Vallejo, M. C.; Sarkar, S.; Elliott, E. C.; Henry, H. R.; Huang, F.; Payne, S. H.; Ramanadham, S.; Sims, E. K.; Metz, T. O.; Mirmira, R.; Nakayasu, E. S.
10.1101/2022.09.28.509996 — cell biology — Posted on 2022-09-29
278 A grappling hook interaction balances self-assembly and chaperone activity of Nucleophosmin 1
Saluri, M.; Leppert, A.; Gese, G. V.; Sahin, C.; Lama, D.; Kaldmae, M.; Chen, G.; Elofsson, A.; Allison, T. M.; Arsenian-Henriksson, M.; Lane, D. P.; Johansson, J.; Hallberg, B. M.; Landreh, M.
10.1101/2022.09.29.510028 — biophysics — Posted on 2022-09-29
279 De novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography
Chen, Z.; Shiozaki, M.; Haas, K. M.; Zhao, S.; Guo, C.; Polacco, B. J.; Yu, Z.; Krogan, N. J.; Kaake, R. M.; Vale, R. D.; Agard, D. A.
10.1101/2022.09.28.510016 — biophysics — Posted on 2022-09-29
281 The generation of the first chromosome-level de-novo genome assembly and the development and validation of a 50K SNP array for North American Atlantic salmon
Gao, G.; Waldbieser, G. C.; Youngblood, R. C.; Zhao, D.; Pietrak, M.; Allen, M.; Stannard, J.; Buchanan, J.; Long, R.; Milligan, M.; Burr, G.; Mejia-Guerra, K.; Sheehan, M.; Scheffler, B. E.; Rexroad, C.; Peterson, B.; Palti, Y.
10.1101/2022.09.28.509896 — genomics — Posted on 2022-09-29
282 TGFβ-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma
Papoutsoglou, P.; Louis, C.; Pineau, R.; L'Haridon, A.; Banales, J. M.; Gilot, D.; Aubry, M.; Coulouarn, C.
10.1101/2022.09.28.509889 — cancer biology — Posted on 2022-09-29
283 Exosome-derived lncRNA HOXA-AS3 promotes castration resistance and progression of prostate cancer via the miR-29b-3p/Mcl-1/STAT3 axis
Jie, T.; Cai, Q.; Zhao, Y.; Shang, L.; Li, Y.; Zhang, J.; Zhu, L.; Chen, Y.; Li, G.; Liu, Z.; Jia, M.; Kang, S.; Niu, H.; Niu, Y.
10.1101/2022.09.28.509879 — genomics — Posted on 2022-09-29
286 Investigation of the genus Flavobacterium as a reservoir for fish-pathogenic bacterial species: the case of Flavobacterium collinsii
Duchaud, E.; Lee, B.-H.; Nicolas, P.; Saticioglu, I. B.; Fradet, B.; Bernardet, J.-F.; Rigaudeau, D.; Rochat, T.
10.1101/2022.09.27.509832 — microbiology — Posted on 2022-09-29
287 The Arabidopsis SHORTROOT network coordinates shoot apical meristem development with auxin dependent lateral organ initiation
Bahafid, E.; Bradtmöller, I.; Thies, A. M.; Nguyen, T. T. O. N.; Gutierrez, C.; Desvoyes, B.; Stahl, Y.; Blilou, I.; Simon, R. G.
10.1101/2022.09.27.509828 — plant biology — Posted on 2022-09-29
288 Abnormal intrinsic neural timescale in Parkinson's disease
Wei, Y.; Zhang, C.; Peng, Y.; Chen, C.; Han, S.; Wang, W.; Zhang, Y.; Lu, H.; Cheng, J.
10.1101/2022.09.17.508074 — neuroscience — Posted on 2022-09-29
290 36-year study reveals the effects of microhabitats on a wild wheat population
Dahan-Meir, T.; Ellis, T. J.; Mafessoni, F.; Sela, H.; Rudich, O.; Manisterski, J.; Avivi-Ragolsky, N.; Raz, A.; Feldman, M.; Anikster, Y.; Nordborg, M.; Levy, A. A.
10.1101/2022.01.10.475641 — evolutionary biology — Posted on 2022-09-29
293 Tubule jamming in the developing kidney creates cyclical mechanical stresses instructive to nephron formation
Viola, J. M.; Liu, J.; Prahl, L. S.; Huang, A.; Chan, T. J.; Hayward-Lara, G.; Porter, C. M.; Shi, C.; Zhang, J.; Hughes, A. J.
10.1101/2022.06.03.494718 — bioengineering — Posted on 2022-09-29
295 A moonlighting function of Atg11 in spindle positioning
Reza, M. H.; Aggarwal, R.; Verma, J.; Chowdhury, R.; Manjithaya, R.; Sanyal, K.
10.1101/2021.12.15.472744 — genetics — Posted on 2022-09-28
297 Active Translation Control of CD4 T Cell Activation by Regulatory T Cells
So, L.; Obata-Ninomiya, K.; Hu, A.; Muir, V.; Takamori, A.; Song, J.; Buckner, J. H.; Savan, R.; Ziegler, S.
10.1101/2021.09.23.461566 — immunology — Posted on 2022-09-28
299 Silicone Oil-Induced Glaucomatous Neurodegeneration in Rhesus Macaques
Moshiri, A.; Fang, F.; Zhuang, P.; Huang, H.; Feng, X.; Li, L.; Dalal, R.; Hu, Y.
10.1101/2022.06.06.494980 — neuroscience — Posted on 2022-09-29
300 Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer
Lin, J.-R.; Wang, S.; Coy, S.; Chen, Y.-A.; Yapp, C.; Tyler, M. A.; Nariya, M.; Heiser, C. N.; Lau, K.; Santagata, S.; Sorger, P. K.
10.1101/2021.03.31.437984 — cancer biology — Posted on 2022-09-28
301 Combined Scattering, Interferometric and Fluorescence Oblique Illumination for Live Cell Nanoscale Imaging
Zheng, Y.; Lim, Y. J.; Lin, H.; Xu, T.; Longbottom, C.; Delghingaro-Augusto, V.; Thong, Y. L.; Parish, C. R.; Gardiner, E. E.; Lee, W. M.
10.1101/2022.07.22.501104 — biophysics — Posted on 2022-09-28
303 Synthetic regulatory genomics uncovers enhancer context dependence at the Sox2 locus
Brosh, R.; Coelho, C.; Ribeiro-dos-Santos, A. M.; Ellis, G.; Hogan, M. S.; Ashe, H. J.; Somogyi, N.; Ordonez, R.; Luther, R.; Huang, E.; Boeke, J. D.; Maurano, M. T.
10.1101/2022.06.20.495832 — genomics — Posted on 2022-09-28
304 Omnigenic epistasis regulates complex trait heritability
Miller, A. K.; Pan, C.; Lusis, A. J.; Crawford, D. C.; Williams, S. M.; Buchner, D. A.
10.1101/2022.09.28.509932 — genetics — Posted on 2022-09-28
306 CTCF and R-loops are boundaries of cohesin-mediated DNA looping
Zhang, H.; Shi, Z.; Kim, Y.; Yu, H.; Bai, X.-c.; Finkelstein, I. J.
10.1101/2022.09.15.508177 — molecular biology — Posted on 2022-09-28
307 Interleukin-17 drives sex-dependent weight loss and changes in feeding behaviour during Trypanosoma brucei infection
Sinton, M. C.; Girard, A.; Ogunsola, J.; Chandrasegaran, P.; Capewell, P.; Perona-Wright, G.; Ngoyi, D.; Kuispond, N.; BUCHETON, B.; Camara, M.; Kajimura, S.; Benezech, C.; MacLeod, A.; Quintana Alcala, J. F.
10.1101/2022.09.23.509158 — immunology — Posted on 2022-09-28
308 Criticality of neuronal avalanches in human sleep and their relationship with sleep macro- and micro-architecture
Scarpetta, S.; Morrisi, N.; Mutti, C.; Azzi, N.; Trippi, I.; Ciliento, R.; Apicella, I.; Messuti, G.; Angiolelli, M.; Lombardi, F.; Parrino, L.; Vaudano, A. E.
10.1101/2022.07.12.499725 — neuroscience — Posted on 2022-09-28
312 How many sirtuin genes are out there? evolution of sirtuin genes in vertebrates with a description of a new family member
Opazo, J. C.; Vandewege, M.; Hoffmann, F. G.; Zavala, K.; Melendez, C.; Luchsinger, C.; Cavieres, V.; Vargas-Chacoff, L.; Morera, F.; Burgos, P.; Tapia-Rojas, C.; Mardones, G.
10.1101/2020.07.17.209510 — evolutionary biology — Posted on 2022-09-28
313 Trade-offs constrain adaptive pathways to T6 survival
MacGillivray, K. A.; Ng, S. L.; Wiesenfeld, S.; Guest, R. L.; Jubery, T.; Silhavy, T. J.; Ratcliff, W. C.; Hammer, B. K.
10.1101/2022.09.02.506412 — evolutionary biology — Posted on 2022-09-28
314 Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment
Whalen, S.; Inoue, F.; Ryu, H.; Fair, T.; Markenscoff-Papadimitriou, E.; Keough, K.; Kircher, M.; Martin, B.; Alvarado, B.; Elor, O.; Cintron, D. L.; Williams, A.; Samee, M. A. H.; Thomas, S.; Krencik, R.; Ullian, E.; Kriegstein, A.; Shendure, J.; Pollen, A.; Ahituv, N.; Pollard, K. S.
10.1101/256313 — evolutionary biology — Posted on 2022-09-28
316 OnRamp: rapid nanopore plasmid validation
Mumm, C.; Drexel, M. L.; McDonald, T. L.; Diehl, A.; Switzenberg, J. A.; Boyle, A. P.
10.1101/2022.03.15.484480 — molecular biology — Posted on 2022-09-28
317 Automated hippocampal unfolding for morphometry and subfield segmentation with HippUnfold
DeKraker, J.; Haast, R. A.; Yousif, M. D.; Karat, B.; Lau, J. C.; Kohler, S.; Khan, A. R.
10.1101/2021.12.03.471134 — neuroscience — Posted on 2022-09-28
319 Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming.
Keine, C.; Al-Yaari, M.; Radulovic, T.; Thomas, C. I.; Valino Ramos, P.; Guerrero-Given, D.; Ranjan, M.; Taschenberger, H.; Kamasawa, N.; Young, S. M.
10.1101/2022.06.29.497712 — neuroscience — Posted on 2022-09-28
321 Intrinsic neural timescales in the temporal lobe support an auditory processing hierarchy
Cusinato, R.; Alnes, S. L.; van Maren, E.; Boccalaro, I.; Ledergerber, D.; Adamantidis, A.; Imbach, L. L.; Schindler, K.; Baud, M. O.; Tzovara, A.
10.1101/2022.09.27.509695 — neuroscience — Posted on 2022-09-28
322 TemplateFlow: FAIR-sharing of multi-scale, multi-species brain models
Ciric, R.; Thompson, W. H.; Lorenz, R.; Goncalves, M.; MacNicol, E.; Markiewicz, C.; Halchenko, Y.; Ghosh, S. S.; Gorgolewski, K. J.; Poldrack, R.; Esteban, O.
10.1101/2021.02.10.430678 — neuroscience — Posted on 2022-09-28
329 Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice
von Strempel, A.; Weiss, A. S.; Wittmann, J.; Salvado Silva, M.; Ring, D.; Wortmann, E.; Clavel, T.; Debarbieux, L.; Kleigrewe, K.; Stecher, B.
10.1101/2022.09.28.509654 — microbiology — Posted on 2022-09-28
330 Nirmatrelvir-resistant SARS-CoV-2 is efficiently transmitted in Syrian hamsters
Abdelnabi, R.; Jochmans, D.; Donckers, K.; Trueeb, B.; Ebert, N.; Weynand, B.; Thiel, V.; Neyts, J.
10.1101/2022.09.28.509903 — microbiology — Posted on 2022-09-28
332 Activation of SARS-CoV-2 by trypsin-like proteases in the clinical specimens of patients with COVID-19
Igarashi, E.; Shimada, T.; Yazawa, S.; Saga, Y.; Itamochi, M.; Inasaki, N.; Morinaga, Y.; Oishi, K.; Tani, H.
10.1101/2022.09.27.509803 — microbiology — Posted on 2022-09-28
333 Mutational spectra distinguish SARS-CoV-2 replication niches
Ruis, C.; Peacock, T. P.; Polo, L. M.; Masone, D.; Soledad Alvarez, M.; Hinrichs, A. S.; Turakhia, Y.; Ye, C.; McBroome, J.; Corbett-Detig, R.; Parkhill, J.; Floto, R. A.
10.1101/2022.09.27.509649 — microbiology — Posted on 2022-09-28
334 Synthetic carbon fixation via the autocatalytic serine threonine cycle
Wenk, S.; Rainaldi, V.; He, H.; Schann, K.; Bouzon, M.; Doering, V.; Lindner, S.; Bar-Even, A.
10.1101/2022.09.28.509898 — synthetic biology — Posted on 2022-09-28
335 TRAF6 modulates PD-L1 expression through YAP1-TFCP2 signaling in melanoma
Liu, X.; Wang, L.; Han, Y.; Tsai, H.-i.; Shu, F.; Xu, Z.; He, C.; Zhu, H.; Chen, H.; Cheng, F.
10.1101/2022.09.28.509909 — cancer biology — Posted on 2022-09-28
338 DASH/Dam1 complex mutants stabilize ploidy by weakening kinetochore-microtubule attachments
Haase, M. A. B.; Olafsson, G.; Flores, R. L.; Boakye-Ansah, E.; Zelter, A.; Dickinson, M. S.; Stefanita, L. L.; Truong, D. M.; Asbury, C. L.; Davis, T. N.; Boeke, J. D.
10.1101/2022.09.28.509901 — genetics — Posted on 2022-09-28
341 Structural insights into TRAP association with ribosome-Sec61 complex, and translocon inhibition by a CADA derivative
Pauwels, E.; Shewakramani, N. R.; De Wijngaert, B.; Camps, A.; Provinciael, B.; Stroobants, J.; Kalies, K.-U.; Hartmann, E.; Maes, P.; Vermeire, K.; Das, K.
10.1101/2022.09.28.509949 — cell biology — Posted on 2022-09-28
342 HSV-1 infection induces a downstream shift of promoter-proximal pausing linked to H2A.Z-containing +1 nucleosomes
Weiss, E.; Hennig, T.; Grassl, P.; Djakovic, L.; Whisnant, A. W.; Juerges, C. S.; Koller, F.; Kluge, M.; Erhard, F.; Doelken, L.; Friedel, C. C.
10.1101/2022.09.28.509911 — molecular biology — Posted on 2022-09-28
343 A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
dos Reis, T. F.; de Castro, P. A.; Bastos, R.; Pinzan, C. F.; Souza, P. F.; Ackloo, S.; Hossain, M. A.; Drewry, D.; Alkhazraji, S.; Ibrahim, A.; Jo, H.; deGrado, W. F.; Goldman, G.
10.1101/2022.09.28.509882 — microbiology — Posted on 2022-09-28
344 Achieving quantitative and accurate measurement of the human gut microbiome
Maghini, D. G.; Dvorak, M.; Dahlen, A.; Roos, M.; Kuersten, S.; Bhatt, A. S.
10.1101/2022.09.28.509972 — microbiology — Posted on 2022-09-28
352 ePlatypus: an ecosystem for computational analysis of immunogenomics data
Kreiner, V.; Agrafiotis, A.; Cotet, T.-S.; Kuhn, R.; Shlesinger, D.; Manero-Carranza, M.; Khodaverdi, K.; Masserey, S.; Guerci, L.; Hong, K.-L.; Han, J.; Stiklioraitis, K.; Martinolli, V.; Dizerens, R.; Kilchenmann, S.; Stalder, L.; Nissen, L.; Vogelsanger, B.; Anzböck, S.; Laslo, D.; Kondorosy, M.; Venerito, M.; Garcia, A. S.; Feller, I.; Oxenius, A.; Reddy, S. T.; Yermanos, A.
10.1101/2022.09.28.509709 — immunology — Posted on 2022-09-28
353 eIF4E phosphorylation recruits β-catenin to mRNA cap and selectively promotes Wnt pathway translation in dentate gyrus LTP maintenance in vivo
Patil, S.; Chalkiadaki, K.; Mergiya, T.-F.; Simbriger, K.; Amorim, I. S.; Akerkar, S.; Gkogkas, C. G.; Bramham, C. R.
10.1101/2022.09.28.509312 — neuroscience — Posted on 2022-09-28
356 Control of lipolysis by a population of oxytocinergic sympathetic neurons
Li, E.; Wang, L.; Wang, D.; Chi, J.; Smith, G.; Klein, S.; Cohen, P.; Rosen, E.
10.1101/2022.09.27.509745 — physiology — Posted on 2022-09-28
357 The transcriptional landscape of glycosylation-related genes in cancer
Rodriguez, E.; Lindijer, D.; van Vliet, S. J.; Garcia-Vallejo, J. J.; van Kooyk, Y.
10.1101/2022.09.28.509853 — cancer biology — Posted on 2022-09-28
359 m6A-ELISA, a simple method for quantifying N6-methyladenosine from mRNA populations
Ensinck, I.; Sideri, T.; Modic, M.; Capitanchik, C.; Toolan-Kerr, P.; van Werven, F.
10.1101/2022.09.27.509679 — biochemistry — Posted on 2022-09-28
362 Hybridisation has shaped a recent radiation of grass-feeding aphids
Mathers, T. C.; Wouters, R. H. M.; Mugford, S. T.; Biello, R.; Van Oosterhout, C.; Hogenhout, S. A.
10.1101/2022.09.27.509720 — evolutionary biology — Posted on 2022-09-28
364 Seascape genomics reveals limited dispersal and suggest spatially varying selection among European populations of sea lamprey (Petromyzon marinus)
Baltazar-Soares, M.; Britton, J. R.; Pinder, A.; Harrison, A. J.; Nunn, A. D.; Quintella, B. R.; Mateus, C. S.; Bolland, J. D.; Dodd, J. R.; Almeida, P. R.; Almela, V. D.; Andreou, D.
10.1101/2022.09.28.509639 — evolutionary biology — Posted on 2022-09-28
365 Multi-scale observations of mangrove blue carbon fluxes; the NASA Carbon Monitoring System BlueFlux field campaign
Poulter, B.; Adams, F.; Amaral, C.; Barenblitt, A.; Campbell, A.; Charles, S.; Cuesta, R.; Delaria, E.; Doughty, C.; Fatoyinbo, T.; Gewirtzman, J.; Hanisco, T.; Hull, M.; Kawa, R.; Hannun, R.; Lagomasino, D.; Lait, L.; Malone, S.; Newman, P.; Raymond, P.; Rosentreter, J.; Thomas, N.; Wolfe, G.; Xiong, L.; Ying, Q.; Zhang, Z.
10.1101/2022.09.27.509753 — ecology — Posted on 2022-09-28
368 Nature of epigenetic aging from a single-cell perspective
Tarkhov, A. E.; Lindstrom-Vautrin, T.; Zhang, S.; Ying, K.; Moqri, M.; Zhang, B.; Gladyshev, V. N.
10.1101/2022.09.26.509592 — systems biology — Posted on 2022-09-28
370 Effects of more natural housing conditions on the muscular and skeletal characteristics of female C57BL/6J mice
Mieske, P.; Scheinpflug, J.; Yorgan, T.; Brylka, L.; Palme, R.; Hobbiesiefken, U.; Preikschat, J.; Diederich, K.; Lewejohann, L.
10.1101/2022.09.27.509671 — physiology — Posted on 2022-09-28
372 CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells
Roulstone, V.; Kyula, J.; Wright, J.; Yu, L.; Barreiro Alonso, A.; Melake, M.; Choudhary, J.; Elliott, R.; Lord, C. J.; Mansfield, D.; Matthews, N.; Chauhan, R.; Jennings, V.; Chan, C.; Baldock, H.; Butera, F. J.; Appleton, E.; Nenclares, P.; Pedersen, M.; Foo, S.; Patin, E. C.; Rullan, A.; Tenev, T.; Meier, P.; van Vloten, J.; Vile, R.; Pandha, H.; Melcher, A.; McLaughlin, M.; Harrington, K. J.
10.1101/2022.09.28.508679 — cancer biology — Posted on 2022-09-28
373 Bridging-mediated compaction of mitotic chromosomes
Forte, G.; Boteva, L.; Gilbert, N.; Cook, P. R.; Marenduzzo, D.
10.1101/2022.09.27.509716 — biophysics — Posted on 2022-09-28
374 Moving beyond MARCO
Newman, J. M.; Rosa, N.; Watkins, C. J.
10.1101/2022.09.28.509867 — biophysics — Posted on 2022-09-28
375 A full computational model of cell motility: Early spreading, cell migration and competing taxis
Betorz, J.; Bokil, G. R.; Deshpande, S. M.; Kulkarni, S.; Rolando, D.; Venturini, C.; Saez, P.
10.1101/2022.09.28.509519 — biophysics — Posted on 2022-09-28
377 Quartet DNA reference materials and datasets for comprehensively evaluating germline variants calling performance
Ren, L.; Duan, X.; Dong, L.; Zhang, R.; Yang, J.; Gao, Y.; Peng, R.; Hou, W.; Liu, Y.; Li, J.; Yu, Y.; Zhang, N.; Shang, J.; Liang, F.; Wang, D.; Chen, H.; Sun, L.; Hao, L.; Scherer, A.; Nordlund, J.; Xiao, W.; Xu, J.; Tong, W.; Hu, X.; Jia, P.; Ye, K.; Li, J.; Jin, L.; Shi, L.; Hong, H.; Wang, J.; Fan, S.; Fang, X.; Zheng, Y.
10.1101/2022.09.28.509844 — bioinformatics — Posted on 2022-09-28
382 Permeability transition pore-related changes in the proteome and channel activity of ATP synthase dimers and monomers
Nikiforova, A.; Baburina, Y.; Borisova, M.; Surin, A.; Kharechkina, E.; Krestinina, O.; Suvorina, M.; Kruglova, S.; Kruglov, A.
10.1101/2022.09.28.508998 — biochemistry — Posted on 2022-09-28
383 Driver mutations in GNAQ and GNA11 genes as potential targets for precision immunotherapy in uveal melanoma patients
Garcia-Mulero, S.; Fornelino, R.; Punta, M.; Lise, S.; Varela, M.; Moreno, R.; Costa-Garcia, M.; Gros, A.; Alemany, R.; Piulats, J. M.; Sanz-Pamplona, R.
10.1101/2022.09.28.509834 — genomics — Posted on 2022-09-28
385 Genetic Regulators of Sputum Mucin Concentration and Their Associations with COPD Phenotypes
Van Buren, E.; Radicioni, G.; Lester, S.; O'Neal, W.; Dang, H.; Kasela, S.; Gardadri, S.; Curtis, J.; Han, M.; Krishnan, J.; Wan, E.; Silverman, E.; Hastie, A.; Ortega, V.; Lappalainen, T.; Christenson, S.; Li, Y.; Cho, M.; Kesimer, M.; Kelada, S.
10.1101/2022.09.28.509838 — genetics — Posted on 2022-09-28
386 Enrichment of phenotype among biological forms of Anopheles stephensi Liston through establishment of isofemale lines
Ghosh, C.; Kumar, N.; Kushwah, R. B. S.; M, S.; Joshi, S. G.; R, C. K.; Alalamath, T.; Srinivasan, S.; Subramani, S.; Kumar, S.; Swain, S.
10.1101/2022.09.28.509862 — genetics — Posted on 2022-09-28
392 Acclimating to degraded environments: The social rationale for swift action on restoration
Karatayev, V. A.; Wilson, R. S.; Webster, D. G.; Axelrod, M.; Bauch, C. T.; Anand, M.
10.1101/2022.09.27.509807 — ecology — Posted on 2022-09-28
394 Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function
Lampersberger, L.; Conte, F.; Ghosh, S.; Xiao, Y.; Price, J.; Jordan, D.; Matus, D. Q.; Sarkies, P.; Beli, P.; Miska, E. A.; Burton, N. O.
10.1101/2022.09.27.509717 — developmental biology — Posted on 2022-09-28
395 A filamentous phage triggers antiviral responses in cystic fibrosis basal airway epithelial cells
Popescu, M. C.; Haddock, N. L.; Burgener, E. B.; Rojas-Hernandez, L. S.; Kaber, G.; Hargil, A.; Bollyky, P.; Milla, C. E.
10.1101/2022.09.27.509771 — cell biology — Posted on 2022-09-28
397 Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts
Blokland, K. E. C.; Nizamoglu, M.; Habibie, H.; Borghuis, T.; Schuliga, M.; Melgert, B. N.; Knight, D. A.; Brandsma, C.-A.; Pouwels, S. D.; Burgess, J. K.
10.1101/2022.09.27.509806 — cell biology — Posted on 2022-09-28
398 Structural and Immunological Similarities Between the Metacyclic and Bloodstream Form Variant Surface Glycoproteins of the African Trypanosome
Chandra, M.; Dakovic, S.; Foti, K.; Zeelen, J.; van Straaten, M.; Aresta-Branco, F.; Tihon, E.; Luebbehusen, N.; Ruppert, T.; Glover, L.; Papavasiliou, F. N.; Stebbins, C. E.
10.1101/2022.09.28.508705 — microbiology — Posted on 2022-09-28
400 Commensal-specific CD4 T cells promote inflammation in the central nervous system via molecular mimicry
White, Z.; Cabrera, I.; Ochoa-Raya, A.; Kapustka, I.; Koster, K. P.; Matsuo, T.; Jayawardena, D.; Kageyama, T.; Dudeja, P. K.; Lutz, S. E.; Yoshii, A.; Sano, T.
10.1101/2022.09.27.509786 — immunology — Posted on 2022-09-28
401 Cellular proteomic profiling using proximity labelling by TurboID-NES in microglial and neuronal cell lines.
Sunna, S.; Bowen, C.; Zeng, H.; Rayaprolu, S.; Kumar, P.; Bagchi, P.; Guo, Q.; Duong, D. M.; Bitarafan, S.; Natu, A.; Wood, L.; Seyfried, N. T.; Rangaraju, S.
10.1101/2022.09.27.509765 — neuroscience — Posted on 2022-09-28
404 Disruption of Tonic Endocannabinoid Signaling Triggers the Generation of a Stress Response
Petrie, G.; Balsevich, G.; Fuzesi, T.; Aukema, R.; Wouter, D.; Van der Stelt, M.; Bains, J. S.; Hill, M. N.
10.1101/2022.09.27.509585 — neuroscience — Posted on 2022-09-28
406 Cones and Cone Pathways Remain Functional in Advanced Retinal Degeneration
Ellis, E. M.; Paniagua, A. E.; Scalabrino, M. L.; Thapa, M.; Rathinavelu, J.; Jiao, Y.; Williams, D. S.; Field, G. D.; Fain, G. L.; Sampath, A. P.
10.1101/2022.09.27.509752 — neuroscience — Posted on 2022-09-28
409 A scalable screening platform for phenotypic subtyping of ALS patient-derived fibroblasts
Kumbier, K.; Roth, M.; Li, Z.; Lazzari-Dean, J.; Waters, C.; Huang, P.; Korobeynikov, V.; Consortium, N. Y. G. C.; Phatnani, H.; Schneider, N.; Jacobson, M.; Wu, L.; Altschuler, S.
10.1101/2022.09.27.509770 — systems biology — Posted on 2022-09-28
410 A Genome Scale Transcriptional Regulatory Model of the Human Placenta
Paquette, A. G.; Ahuna, K.; Hwang, Y. M.; Pearl, J.; Liao, H.; Shannon, P.; Kadam, L.; Lapehn, S.; Bucher, M.; Roper, R.; Funk, C. C.; MacDonald, J.; Bammler, T.; Baloni, P.; Brockway, H.; Mason, W. A.; Bush, N.; LeWinn, K. Z.; Carr, C. J.; Stamatoyannopoulos, J.; Muglia, L. J.; Jones, H. M.; Sadovsky, Y.; Myatt, L.; Sathyanarayana, S.; Price, N.; Environmental influences on Child Health Outcomes,
10.1101/2022.09.27.509541 — systems biology — Posted on 2022-09-28
411 The Quartet Data Portal: integration of community-wide resources for multiomics quality control
Yang, J.; Liu, Y.; Shang, J.; Chen, Q.; Chen, Q.; Ren, L.; Zhang, N.; Yu, Y.; Li, Z.; Song, Y.; Yang, S.; Scherer, A.; Tong, W.; Hong, H.; Shi, L.; Xiao, W.; Zheng, Y.
10.1101/2022.09.26.507202 — systems biology — Posted on 2022-09-28
412 Multi-scale spatial modeling of immune cell distributions enables survival prediction in primary central nervous system lymphoma
Roemer, M. G. M.; van de Brug, T.; Bosch, E.; Berry, D.; Hijmering, N.; Stathi, P.; Weijers, K.; Doorduijn, J.; Broemberg, J.; van de Wiel, M.; Ylstra, B.; de Jong, D.; Kim, Y.
10.1101/2022.09.27.509403 — systems biology — Posted on 2022-09-28
414 Testing the evolutionary drivers of nitrogen-fixing symbioses in challenging soil environments
Siniscalchi, C. M.; Kates, H. R.; Soltis, P. R.; Soltis, D. E.; Guralnick, R. P.; Folk, R. A.
10.1101/2022.09.27.509719 — plant biology — Posted on 2022-09-28
416 The p-rpS6-zone delineates wounding response and the healing process
Ring, N. A. R.; Dworak, H.; Bachmann, B.; Schaedl, B.; Valdivieso, K.; Rozmaric, T.; Heimel, P.; Schuetzenberger, K.; Leinfellner, G.; Ferguson, J.; Drechsler, S.; Mildner, M.; Schosserer, M.; Slezak, P.; Meyuhas, O.; Gruber, F.; Grillari, J.; Redl, H.; Ogrodnik, M.
10.1101/2022.09.27.507541 — physiology — Posted on 2022-09-28
419 Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Vuckovic, Z.; Wang, J.; Pham, V.; Mobbs, J. I.; Belousoff, M. J.; Bhattarai, A.; Burger, W. A. C.; Thompson, G.; Yeasmin, M.; Leach, K.; van der Westhuizen, E. T.; Khajehali, E.; Liang, Y.-L.; Glukhova, A.; Wootten, D.; Lindsley, C. W.; Tobin, A.; Sexton, P.; Danev, R.; Valant, C.; Miao, Y.; Christopoulos, A.; Thal, D. M.
10.1101/2022.09.27.509640 — pharmacology and toxicology — Posted on 2022-09-28
420 Integrative Single Cell Multiomic Profiling Analysis Reveals HOX-PBX Gene Regulatory Network Contributing to the Survival of mTOR Hyperactive Cells
Olatoke, T. F.; Wagner, A.; Astrinidis, A. A.; Guo, M.; Zhang, E. Y.; Zhang, A. A.; Mattam, U.; Chilton, K.; Kopras, E. J.; Gupta, N.; Smith, E. P.; Karbowniczek, M.; Markiewski, M. M.; Wikenheiser-Brokamp, K.; Whitsett, J. A.; McCormack, F. X.; Xu, Y.; Yu, J. J.
10.1101/2022.09.27.509560 — cancer biology — Posted on 2022-09-28
421 Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models
Rodriguez-Berriguete, G.; Ranzani, M.; Prevo, R.; Puliyadi, R.; Machado, N.; Bolland, H. R.; Millar, V.; Ebner, D.; Boursier, M.; Cerutti, A.; Cicconi, A.; Galbiati, A.; Grande, D.; Grinkevich, V.; Majithiya, J.; Piscitello, D.; Rajendra, E.; Stockley, M.; Boulton, S. J.; Hammond, E. M.; Heald, R.; Smith, G. C. M.; Robinson, H.; Higgins, G. S.
10.1101/2022.09.27.509658 — cancer biology — Posted on 2022-09-28
422 miR-28 plus ibrutinib as a novel combination therapy for Diffuse Large B Cell Lymphoma
Fuertes, T.; Alvarez-Corrales, E.; Ubieto-Capella, P.; Serrano-Navarro, A.; Gomez-Escolar, C.; de Molina, A.; Mendez, J.; Ramiro, A. R.; de Yebenes, V. G.
10.1101/2022.09.27.509662 — cancer biology — Posted on 2022-09-28
423 CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer
Houthuijzen, J. M.; de Bruijn, R.; van der Burg, E.; Drenth, A. P.; Wientjens, E.; Filipovic, T.; Bullock, E.; Brambillasca, C. S.; Nieuwland, M.; de Rink, I.; van Diepen, F.; Klarenbeek, S.; Kerkhoven, R.; Brunton, V.; Scheele, C. L. G. J.; Boelens, M. C.; Jonkers, J.
10.1101/2022.09.27.509697 — cancer biology — Posted on 2022-09-28
424 PINK1 supports colorectal cancer growth by regulating the labile iron pool.
Chen, B.; Das, N. K.; Talukdar, I.; Singhal, R.; Castillo, C.; Andren, A.; Mancias, J. D.; Lyssiotis, C. A.; Shah, Y. M.
10.1101/2022.09.27.509713 — cancer biology — Posted on 2022-09-28
425 L1 retrotransposition is regulated post-transcriptionally In High-Grade Serous Ovarian Cancer
Pradhan, B.; Zhang, K.; Li, Y.; Lavikka, K.; Muranen, T.; Huhtinen, K.; Badge, R. M.; Burns, K.; Hynninen, J.; Hietanen, S.; Oikkonen, J.; Hautaniemi, S.; Kauppi, L.
10.1101/2022.09.27.509826 — cancer biology — Posted on 2022-09-28
427 Caveolae govern plasma membrane mechanics to protect cells against EDIN B-induced transcellular tunnel formation and lethality from S. aureus septicaemia
Morel, C.; Lemerle, E.; Tsai, F.-C.; Obadia, T.; Srivastava, N.; Marechal, M.; Salles, A.; Albert, M.; Stefani, C.; Lamaze, C.; Vassilopoulos, S.; Piel, M.; Bassereau, P.; Gonzalez-Rodriguez, D.; Leduc, C.; Lemichez, E.
10.1101/2022.09.27.509635 — biophysics — Posted on 2022-09-28
431 Virtual histology of Alzheimer's Disease: why are amyloid-β plaques visible with X-ray phase-contrast imaging?
Chourrout, M.; Sandt, C.; Weitkamp, T.; Ducic, T.; Meyronet, D.; Baron, T.; Klohs, J.; Rama, N.; Boutin, H.; Singh, S.; Olivier, C.; Wiart, M.; Brun, E.; Bohic, S.; Chauveau, F.
10.1101/2022.09.27.509706 — biophysics — Posted on 2022-09-28
433 DREAMS: Deep Read-level Error Model for Sequencing data applied to low-frequency variant calling and circulating tumor DNA detection
Christensen, M. H.; Drue, S.; Rasmussen, M. H.; Frydendahl, A.; Lyskjaer, I.; Demuth, C.; Nors, J.; Gotschalck, K. A.; Iversen, L. H.; Andersen, C. L.; Pedersen, J. S.
10.1101/2022.09.27.509150 — bioinformatics — Posted on 2022-09-28
435 Analysis of the abomasal transcriptome of LDA affected cattle
Gal, Z.; Biro, B.; Nagy, Z.; Kontra, L.; Horvath, A.; Hoffmann, O. I.
10.1101/2022.09.27.509652 — bioinformatics — Posted on 2022-09-28
436 Real-Time Spatial Registration for 3D Human Atlas
Chen, L.; Teng, D.; Zhu, T.; Kong, J.; Herr, B.; Bueckle, A.; Borner, K.; Wang, F.
10.1101/2022.09.27.509335 — bioinformatics — Posted on 2022-09-28
440 Targeting the Hedgehog Signaling Pathway to Improve Tendon-to-Bone Integration
Kamalitdinov, T. B.; Fujino, K.; Lang, S. K.; Jiang, X.; Madi, R.; Evans, M. K.; Zgonis, M. H.; Kuntz, A. F.; Dyment, N. A.
10.1101/2022.09.27.509810 — bioengineering — Posted on 2022-09-28
442 Yeast mtDNA transcription initiation in single nucleotide addition steps
Goovaerts, Q.; Shen, J.; De Wijngaert, B.; Basu, U.; Patel, S. S.; Das, K.
10.1101/2022.09.27.509796 — biochemistry — Posted on 2022-09-28
446 DNA methylation of the endothelin receptor B makes blue fish yellow
Fang, W.; Blakkan, D.; Bashier, R.; Lee, G. G.; Fernald, R. D.; Alvarado, S. G.
10.1101/2022.09.27.509821 — genetics — Posted on 2022-09-28
453 A Single-Cell Level Comparison of Human Inner Ear Organoids and the Human Cochlea and Vestibular Organs
van der Valk, W. H.; van Beelen, E. S. A.; Steinhart, M. R.; Nist-Lund, C.; de Groot, J. C. M. J.; van Benthem, P. P. G.; Koehler, K. R.; Locher, H.
10.1101/2022.09.28.509835 — developmental biology — Posted on 2022-09-28
457 Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration
Hahn, H.; Daly, C.; Little, J.; Perry-Hauser, N. A.; Inoue, A.; Plouffe, B.; Thomsen, A. R. B.
10.1101/2022.09.27.509755 — cell biology — Posted on 2022-09-28
458 Accurate and efficient constrained molecular dynamics of polymers through Newton's method and special purpose code
Lopez-Villellas, L.; Kjelgaard Mikkelsen, C. C.; Galano-Frutos, J. J.; Marco-Sola, S.; Alastruey-Benede, J.; Ibanez, P.; Moreto, M.; Sancho, J.; Garcia-Risueno, P.
10.1101/2022.09.28.509839 — molecular biology — Posted on 2022-09-28
459 Drug interaction mapping with proximity dependent enzyme recruiting chimeras
Venable, J. D.; Vashisht, A. A.; Rayatpisheh, S.; Lajiness, J. P.; Phillips, D. P.; Brock, A.
10.1101/2022.09.26.509259 — molecular biology — Posted on 2022-09-28
462 Profound immunomodulatory effects of 225Ac-NM600 drive enhanced anti-tumor responsein prostate cancer
de Aguiar Ferreira, C.; Potluri, H. K.; Massey, C.; Grudzinski, J. J.; Carston, A.; Clemons, N.; Thickens, A. S.; Rosenkrans, Z.; Choi, C.; Pinchuk, A.; Kwon, O.; Jeffery, J. J.; Bednarz, B.; Morris, Z.; Weichert, J.; McNeel, D. G.; Hernandez, R.
10.1101/2022.09.26.509374 — immunology — Posted on 2022-09-28
464 Large scale interrogation of retinal cell functions by 1-photon light-sheet microscopy
Roy, S.; Wang, D.; Rudzite, A. M.; Perry, B.; Scalabrino, M. L.; Thapa, M.; Gong, Y.; Sher, A.; Field, G. D.
10.1101/2022.09.26.508527 — neuroscience — Posted on 2022-09-28
465 Cerebral Small Vessel Disease Burden is Associated with Decreased Abundance of Gut Barnesiella intestinihominis Bacterium in the Framingham Heart Study
Fongang, B.; Satizabal, C. L.; Kautz, T. F.; Ngouongo, Y. W.; SherraeMuhammad, J. A.; Vasquez, E.; Mathews, J.; Goss, M.; Saklad, A. R.; Himali, J.; Beiser, A.; Cavazos, J. E.; Mahaney, M. C.; Maestre, G.; DeCarli, C.; Shipp, E. L.; Vasan, R. S.; Seshadri, S.
10.1101/2022.09.27.509283 — neuroscience — Posted on 2022-09-28
467 MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis
Harrington, E. P.; Catenacci, R. B.; Smith, M. D.; Heo, D.; Miller, C. E.; Meyers, K. R.; Glatzer, J.; Bergles, D. E.; Calabresi, P. A.
10.1101/2022.09.27.509669 — neuroscience — Posted on 2022-09-28
470 Trends in self-citation rates in neuroscience literature
Rosenblatt, M.; Mehta, S.; Peterson, H.; Dadashkarimi, J.; Rodriguez, R. X.; Foster, M. L.; Adkinson, B. D.; Liang, Q.; Kimble, V. M.; Ye, J.; McCusker, M. C.; Farruggia, M. C.; Rolison, M.; Westwater, M. L.; Jiang, R.; Noble, S.; Scheinost, D.
10.1101/2022.09.27.509533 — neuroscience — Posted on 2022-09-28
471 Pericytes control vascular stability and auditory spiral ganglion neuron survival
Zhang, Y.; Neng, L.; Sharma, K.; Hou, Z.; Johnson, A.; Song, J.; Dabdoub, A.; Shi, X.
10.1101/2022.09.27.509698 — neuroscience — Posted on 2022-09-28
473 The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease
Iannitelli, A. F.; Kelberman, M. A.; Lustberg, D. J.; Korukonda, A.; McCann, K. E.; Mulvey, B.; Segal, A.; Liles, L. C.; Sloan, S. A.; Dougherty, J.; Weinshenker, D.
10.1101/2022.09.27.509797 — neuroscience — Posted on 2022-09-28
474 Specific connectivity optimizes learning in thalamocortical loops
Lakshminarasimhan, K.; Xie, M.; Cohen, J. D.; Sauerbrei, B.; Hantman, A. W.; Litwin-Kumar, A.; Escola, S.
10.1101/2022.09.27.509618 — neuroscience — Posted on 2022-09-28
477 Spatial tumour gene signature discriminates neoplastic from non-neoplastic compartments in colon cancer: unravelling predictive biomarkers for relapse
Sallinger, K.; Gruber, M.; Mueller, C.-T.; Bonstingl, L.; Pritz, E.; Pankratz, K.; Gerger, A.; Smolle, M. A.; Aigelsreiter, A.; Surova, O.; Svedlund, J.; Nilsson, M.; Kroneis, T.; El-Heliebi, A.
10.1101/2022.09.27.509641 — cancer biology — Posted on 2022-09-28
478 Identification and characterization of four bacteriome- and mycobiome-derived subtypes in tumour and adjacent mucosa tissue of colorectal cancer patients
Salvucci, M.; Poynter, L.; Minerzami, R.; Carberry, S.; O'Byrne, R.; Alexander, J.; Lambrechts, D.; Veselkov, K.; Kinross, J.; Prehn, J. H. M.
10.1101/2022.09.27.509391 — cancer biology — Posted on 2022-09-28
480 Diversity, Equity, and Inclusion in the Melanoma Research Community
Portuallo, M. E.; Lu, D. Y.; Alicea, G. M.; Bolling, J.; Lee, R.; McQuade, J.; Warner, A. B.; Davies, M.; Weeraratna, A.; Villanueva, J.; Rebecca, V. W.
10.1101/2022.09.24.509278 — cancer biology — Posted on 2022-09-28
481 Serum amyloid alpha 1-2 are not required for systemic inflammation in the 4T1 murine breast cancer model
He, C.; Konishi, R.; Harata, A.; Nakamura, Y.; Mizuno, R.; Yoda, M.; Toi, M.; Kawaguchi, K.; Kawaoka, S.
10.1101/2022.09.26.509617 — cancer biology — Posted on 2022-09-28
482 Lineage-specific oncogenes drive growth of major forms of human cancer using common downstream mechanisms
Kauko, O.; Turunen, M.; Pihlajamaa, P.; Hakkinen, A.; Queiroz, R. M.; Paakkonen, M.; Ventela, S.; Gaetani, M.; Lundstrom, S.; Murgia, A.; Sahu, B.; Routila, J.; Irjala, H.; Griffin, J. L.; Lilley, K. S.; Kivioja, T.; Hautaniemi, S.; Taipale, J.
10.1101/2022.09.27.509636 — cancer biology — Posted on 2022-09-28
483 Murine breast cancers disorganize the liver transcriptome in zonated manners
Vandenbon, A.; Mizuno, R.; Konishi, R.; Onishi, M.; Masuda, K.; Kobayashi, Y.; Kawamoto, H.; Suzuki, A.; Shimizu, M.; Tanaka, Y.; Suzuki, Y.; Kawaoka, S.
10.1101/2022.09.27.509354 — cancer biology — Posted on 2022-09-28
488 Phylogenetic inference from single-cell RNA-seq data
Liu, X.; Griffiths, J. I.; Bishara, I.; Liu, J.; Bild, A. H.; Chang, J. T.
10.1101/2022.09.27.509725 — bioinformatics — Posted on 2022-09-28
494 FAM237A, rather than peptide PEN and proCCK56-63, is a ligand of the orphan receptor GPR83
Li, H.-Z.; Wang, Y.-F.; Shao, X.-X.; Liu, Y.-L.; Xu, Z.-G.; Wang, S.-L.; Guo, Z.-Y.
10.1101/2022.09.27.509696 — biochemistry — Posted on 2022-09-28
496 Spatially Resolved Single-cell Translatomics at Molecular Resolution
Zeng, H.; Huang, J.; Ren, J.; Wang, C. K.; Tang, Z.; Zhou, Y.; Aditham, A.; Shi, H.; Sui, X.; Wang, X.
10.1101/2022.09.27.509605 — genomics — Posted on 2022-09-28
503 Rising novelty and homogenization of breeding bird communities in the U.S.
Latimer, C. E.; Graves, R.; Pidgeon, A. M.; Gorzo, J. M.; Henschell, M. M.; Schilke, P. R.; Hobi, M. L.; Olah, A.; Kennedy, C. M.; Zuckerberg, B.; Radeloff, V. C.
10.1101/2022.09.27.509749 — ecology — Posted on 2022-09-28
506 Multimodal mass spectrometry imaging reveals single-cell metabolic states in mammalian liver
Tian, H.; Rajbhandari, P. R.; Tarolli, J.; Decker, A. M.; Neelakantan, T. V.; Angerer, T.; Zandkarimi, F.; Daniels, J.; Remotti, H. R.; Frache, G.; Winograd, N.; Stockwell, B. R.
10.1101/2022.09.26.508878 — cell biology — Posted on 2022-09-28
507 Towards optimised extracellular vesicle proteomics from cerebrospinal fluid
Kangas, P.; Nyman, T. A.; Metsähonkala, L.; Burns, C.; Tempest, R.; Williams, T.; Karttunen, J.; Jokinen, T. S.
10.1101/2022.09.27.508990 — cell biology — Posted on 2022-09-28
509 KaryoCreate: a new CRISPR-based technology to generate chromosome-specific aneuploidy by targeting human centromeres
Bosco, N.; Goldberg, A.; Johnson, A. F.; Zhao, X.; Mays, J. C.; Cheng, P.; Bianchi, J. J.; Toscani, C.; Katsnelson, L.; Annuar, D.; Mei, S.; Faitelson, R. E.; Pesselev, I. Y.; Mohamed, K. S.; Mermerian, A.; Camacho-Hernandez, E. M.; Gionco, C. A.; Manikas, J.; Tseng, Y.-S.; Sun, Z.; Fani, S.; Keegan, S.; Lippman, S. M.; Fenyo, D.; Santaguida, S.; Davoli, T.
10.1101/2022.09.27.509580 — cell biology — Posted on 2022-09-28
511 Vascular-water-exchange MRI (VEXI) enables the detection of subtle BBB breakdown in Alzheimer's disease without MRI contrast agent
Zhang, Y.; Wang, Y.; Li, Z.; Wang, Z.; Cheng, J.; Bai, X.; Hsu, Y.-C.; Sun, Y.; Li, S.; Shi, J.; Sui, B.; Bai, R.
10.1101/2022.09.27.509514 — neuroscience — Posted on 2022-09-28
512 Cannabidiol targets a modulatory system for excitatory-inhibitory synaptic coordination, contributing to its anti-seizure action
Rosenberg, E.; Chamberland, S.; Bazelot, M.; Nebet, E.; Wang, X.; McKenzie, S.; Jain, S.; Greenhill, S.; Wilson, M.; Salah, A.; Bailey, S.; Patra, P. H.; Chenouard, N.; Sun, S.; Jones, D.; Buzsaki, G.; Devinsky, O.; Woodhall, G.; Scharfman, H.; Whalley, B.; Tsien, R.
10.1101/2022.09.27.509638 — neuroscience — Posted on 2022-09-28
513 Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/Omicron variants following an inactivated whole-virus vaccine
Lu, C.; Zhang, Y.; Liu, X.; Hou, F.; Cai, R.; Yu, Z.; Liu, F.; Yang, G.; Ding, J.; Xu, J.; Hua, X.; Pan, X.; Liu, L.; Lin, K.; Wang, Z.; Li, X.; Lu, J.; Zhang, Q.; Li, Y.; Hu, C.; Fan, H.; Liu, X.; Wang, H.; Jia, R.; Xu, F.; Wang, X.; Huang, H.; Zhao, R.; Li, J.; Cheng, H.; Jia, W.; Yang, X.
10.1101/2022.09.06.506714 — molecular biology — Posted on 2022-09-28
514 Model-based whole-brain perturbational landscape of neurodegenerative diseases
Sanz Perl, Y.; Fittipaldi, S.; Gonzalez Campo, C.; Moguilner, S.; Cruzat, J.; Herzog, R.; Kringelbach, M. L.; Deco, G.; Prado, P.; Ibanez, A.; Tagliazucchi, E.
10.1101/2022.09.26.509612 — neuroscience — Posted on 2022-09-28
515 Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice
Tsuji, S.; Brace, C. S.; Yao, R.; Tanie, Y.; Tada, H.; Rensing, N.; Mizuno, S.; Almunia, J.; Kong, Y.; Nakamura, K.; Ogiso, N.; Toyokuni, S.; Takahashi, S.; Wong, M.; Imai, S.-i.; Satoh, A.
10.1101/2022.09.26.509442 — physiology — Posted on 2022-09-28
516 SARS-CoV-2 variants show temperature-dependent enhanced polymerase activity in the upper respiratory tract and high transmissibility
Kim, S.-M.; Kim, E.-H.; Casel, M. A. B.; Kim, Y.-i.; Sun, R.; Kwack, M.-J.; Yoo, J.-S.; Yoo, M.-A.; Yoo, K.-M.; Jang, S.-G.; Rollon, R.; Choi, J. H.; Gil, J.; Eun, K.; Kim, H.; Ensser, A.; Hwang, J.; Song, M.-S.; Kim, M. H.; Jung, J. U.; Choi, Y. K.
10.1101/2022.09.27.509689 — microbiology — Posted on 2022-09-28
518 HB-EGF promotes horizontal basal cell proliferation and olfactory sensory neuron regeneration in the zebrafish olfactory epithelium
Sireci, S.; Kocagöz, Y.; Alkiraz, A. S.; Güler, K.; Dokuzluoglu, Z.; Balcioglu, E.; Demirler, M. C.; Fuss, S. H.
10.1101/2022.09.26.509477 — developmental biology — Posted on 2022-09-28
519 Lysosome repair by ER-mediated cholesterol transfer
Radulovic, M.; Wenzel, E. M.; Gilani, S.; Holland, L. K. K.; Lystad, A. H.; Phuyal, S.; Olkkonen, V. M.; Brech, A.; Jäättelä, M.; Maeda, K.; Raiborg, C.; Stenmark, H.
10.1101/2022.09.26.509457 — cell biology — Posted on 2022-09-28
520 The assembly of wild natural isolates define neuronal integrity and life history traits of co-inhabiting C. elegans.
Urquiza-Zurich, S.; Garcia-Angulo, V. A.; Burdisso, P.; Palominos, M. F.; Fernandez-Hubeid, L.; Castillo, J. P.; Calixto, A.
10.1101/2022.09.26.509631 — microbiology — Posted on 2022-09-28
522 A Multivalent Polyomavirus Vaccine Elicits Durable Neutralizing Antibody Responses in Macaques
Peretti, A.; Scorpio, D. G.; Kong, W.-P.; Pang, Y.-Y. S.; McCarthy, M. P.; Ren, K.; Jackson, M.; Graham, B. S.; Buck, C. B.; McTamney, P. M.; Pastrana, D. V.
10.1101/2022.09.26.509096 — immunology — Posted on 2022-09-28
527 Kazrin is an endosomal adaptor for dynein/dynactin
Hernandez-Perez, I.; Baumann, A.; Rubio, J.; Girao, H.; Rebollo, E.; Aragay, A. M.; Geli, M. I.
10.1101/2021.08.30.458243 — cell biology — Posted on 2022-09-28
528 Alternative mRNA polyadenylation bridges mitochondrion-to-nucleus communication in Arabidopsis
Jia, H.; Zeng, W.; Zhang, X.; Li, J.; Bao, X.; Zhao, Y.; Zhu, L.; Ma, C.; Wang, F.; Guo, X.; Song, C.-P.; Ma, L.; Zhu, X.
10.1101/2022.09.27.509730 — molecular biology — Posted on 2022-09-28
530 In vivo proximity ligation reveals endogenous candidate interactors of Neurexin's intracellular domain
Schaan Profes, M.; Tiroumalechetty, A.; Patel, N.; Lauar, S. S.; Sidoli, S.; Kurshan, P.
10.1101/2022.09.27.509791 — neuroscience — Posted on 2022-09-28
533 Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina
Mantyla, E.; Montonen, T.; Azzari, L.; Mattola, S.; Hannula, M.; Vihinen-Ranta, M.; Hyttinen, J.; Vippola, M.; Foi, A.; Nymark, S.; Ihalainen, T. O.
10.1101/2022.09.27.509734 — molecular biology — Posted on 2022-09-28
534 The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids
Rynne, J.; Ortiz-Zapater, E.; Khooshemehri, P.; Ponde, N. O.; Bucca, G.; Hesketh, A.; Plate, M.; Chambers, R.; Smith, C. P.; Martinez-Nunez, R. T.
10.1101/2022.09.27.509553 — molecular biology — Posted on 2022-09-28
536 The ubiquitin conjugase Rad6 mediates ribosome pausing during oxidative stress
Meydan, S.; Barros, G.; Simoes, V.; Harley, L.; Cizubu, B. K.; Guydosh, N. R.; Silva, G.
10.1101/2022.09.27.509727 — molecular biology — Posted on 2022-09-28
537 AGAL misprocessing-induced ER stress and the unfolded protein response: lysosomal storage-independent mechanism of Fabry disease pathogenesis?
Zivna, M.; Dostalova, G.; Baresova, V.; Musalkova, D.; Kuchar, L.; Asfaw, B.; Poupetova, H.; Vlaskova, H.; Kmochova, T.; Vyletal, P.; Hartmannova, H.; Hodanova, K.; Stranecky, V.; Steiner-Mrazova, L.; Hnizda, A.; Radina, M.; Votruba, M.; Sovova, J.; Treslova, H.; Stolnaja, L.; Rekova, P.; Roblova, L.; Honsova, E.; Hulkova, H.; Rychlik, I.; Bleyer, A. J.; Linhart, A.; Sikora, J.; Kmoch, S.
10.1101/2022.09.27.509714 — molecular biology — Posted on 2022-09-28
538 The TaxUMAP atlas: efficient display of large clinical microbiome data reveals ecological competition involved in protection against bacteremia
Schluter, J.; Djukovic, A.; Taylor, B. P.; Yan, J.; Duan, C.; Hussey, G. A.; Liao, C.; Sharma, S.; Fontana, E.; Amoretti, L. A.; Wright, R. J.; Dai, A.; Peled, J.; Taur, Y.; Perales, M.-A.; Siranosian, B. A.; Bhatt, A. S.; van den Brink, M. R. M.; Pamer, E. G.; Xavier, J. B.
10.1101/2022.09.27.509746 — microbiology — Posted on 2022-09-28
539 Bordetella spp. block eosinophil recruitment to suppress lung iBALT formation
First, N. J.; Martinez, A.; Gonzalez-Fernandez, A.; Bharrhan, S.; Roan, C.; Cox, E.; Wang, J.; Scott, R.; Woolard, M.; Gestal, M. C.
10.1101/2022.09.27.509784 — microbiology — Posted on 2022-09-28
540 Characterization of membrane vesicles in Alteromonas macleodii indicates potential roles in their copiotrophic lifestyle
Fadeev, E.; Carpaneto Bastos, C.; Hennenfeind, J.; Biller, S. J.; Sher, D. J.; Wietz, M.; Herndl, G. J.
10.1101/2022.09.27.509651 — microbiology — Posted on 2022-09-28
545 Cyclitol secondary metabolism is a central feature of Burkholderia leaf symbionts
Danneels, B.; Blignaut, M.; Marti, G.; Sieber, S.; Vandamme, P.; Meyer, M.; Carlier, A.
10.1101/2022.09.27.509721 — microbiology — Posted on 2022-09-28
546 Influenza A virus reassortment is strain dependent
Taylor, K. Y.; Agu, I.; Jose, I. R.; Mantynen, S.; Campbell, A. J.; Mattson, C.; Chou, T.-w.; Zhou, B.; Gresham, D.; Ghedin, E.; Diaz-Munoz, S. L.
10.1101/2022.09.26.509616 — microbiology — Posted on 2022-09-28
548 Copper stress perturbs zinc and manganese homeostasis in Streptococcus pyogenes.
Hong, Y. J.; Mackenzie, E. S.; Firth, S. J.; Bolton, J. F.; Stewart, L. J.; Waldron, K. J.; Djoko, K. Y.
10.1101/2022.09.28.509676 — microbiology — Posted on 2022-09-28
550 Excessive fluid shear stress-mediated Klf4 leads to arteriovenous pathogenesis
Banerjee, K.; Gahn, J.; Lin, Y.; Lei, X.; Gupta, P.; Graupera, M.; Schwartz, M. A.; Ola, R.
10.1101/2022.07.04.498236 — molecular biology — Posted on 2022-09-28
551 Towards In-Silico CLIP-seq: Predicting Protein-RNA Interaction via Sequence-to-Signal Learning
Horlacher, M.; Wagner, N.; Moyon, L.; Kuret, K.; Goedert, N.; Salvatore, M.; Ule, J.; Gagneur, J.; Winther, O.; Marsico, A.
10.1101/2022.09.16.508290 — bioinformatics — Posted on 2022-09-28
554 Transcription factors interact with RNA to regulate genes
Oksuz, O.; Henninger, J. E.; Warneford-Thomson, R.; Zheng, M. M.; Erb, H.; Overholt, K. J.; Hawken, S. W.; Banani, S. F.; Lauman, R.; Vancura, A.; Robertson, A. L.; Hannett, N. M.; Lee, T.; Zon, L. I.; Bonasio, R.; Young, R. A.
10.1101/2022.09.27.509776 — molecular biology — Posted on 2022-09-28
555 Goal-directed vocal planning in a songbird
Zai, A. T.; Stepien, A. E.; Cave-Lopez, S.; Giret, N.; Hahnloser, R. H. R.
10.1101/2022.09.27.509747 — neuroscience — Posted on 2022-09-28
556 Maturational networks of fetal brain activity
Karolis, V. R.; Fitzgibbon, S. P.; Cordero-Grande, L.; Farahibozorg, S.-R.; Price, A. N.; Hughes, E. J.; Fetit, A. E.; Kyriakopoulou, V.; Pietsch, M.; Rutherford, M.; Rueckert, D.; Hajnal, J. V.; Edwards, A. D.; O'Muircheartaigh, J.; Duff, E.; Arichi, T.
10.1101/2022.06.14.495883 — neuroscience — Posted on 2022-09-28
557 Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism
Bridi, M.; Luo, N.; Kim, G.; O'Ferrall, C.; Oatel, R.; Bertrand, S.; Kannan, S.; Kirkwood, A.
10.1101/2021.07.05.451213 — neuroscience — Posted on 2022-09-28
559 Rapid profiling of protein complex re-organization in perturbed systems
Bludau, I.; Nicod, C.; Martelli, C.; Xue, P.; Heusel, M.; Fossati, A.; Uliana, F.; Frommelt, F.; Aebersold, R.; Collins, B. C.
10.1101/2021.12.17.473177 — systems biology — Posted on 2022-09-28
560 Ecological interactions in breast cancer: Cell facilitation promotes growth and survival under drug pressure
Emond, R.; Griffiths, J. I.; Grolmusz, V. K.; Nath, A.; Chen, J.; Medina, E. F.; Sousa, R. S.; Adler, F. R.; Bild, A. H.
10.1101/2021.02.01.429214 — systems biology — Posted on 2022-09-28
563 A Multivariate Approach to Understanding the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders
Poore, H. E.; Hatoum, A.; Mallard, T. T.; Sanchez-Roige, S.; Waldman, I. D.; Palmer, A. A.; Harden, K. P.; Barr, P. B.; Dick, D. M.
10.1101/2022.09.27.509777 — genetics — Posted on 2022-09-28
564 Effects of α-crystallin gene knockout on zebrafish lens development
Posner, M.; Murray, K. L.; Andrew, B.; Brdicka, S.; Butterbaugh-Roberts, A.; Franklin, K.; Hussen, A.; Kaye, T.; Kepp, E.; McDonald, M. S.; Snodgrass, T.; Zientek, K.; David, L. L.
10.1101/2021.12.22.473921 — developmental biology — Posted on 2022-09-28
566 Twist1 and balanced retinoic acid signaling act to suppress cortical folding in mice
Ho-Nguyen, K.-T.; Jain, M.; Matrongolo, M. J.; Ang, P. S.; Schaper, S.; Tischfield, M. A.
10.1101/2022.09.27.509818 — neuroscience — Posted on 2022-09-28
567 The Uniqueness of Human Vulnerability to Brain Aging in Great Ape Evolution
Vickery, S.; Patil, K. R.; Dahnke, R.; Hopkins, W. D.; Sherwood, C. C.; Caspers, S.; Eickhoff, S. B.; Hoffstaedter, F.
10.1101/2022.09.27.509685 — neuroscience — Posted on 2022-09-28
568 Intrinsic neural timescales in the temporal lobe support an auditory processing hierarchy
Cusinato, R.; Alnes, S. L.; van Maren, E.; Boccalaro, I.; Ledergerber, D.; Adamantidis, A.; Imbach, L. L.; Schindler, K.; Baud, M. O.; Tzovara, A.
10.1101/2022.09.27.509695 — neuroscience — Posted on 2022-09-28
569 The development of compulsive coping behaviors depends on the engagement of dorsolateral striatum dopamine-dependent mechanisms
Giuliano, C.; Marti-Prats, L.; Domi, A.; Puaud, M.; Pena-Oliver, Y.; McKenzie, C.; Everitt, B. J.; Belin, D.
10.1101/2022.09.27.509680 — neuroscience — Posted on 2022-09-28
572 Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation
Cheng, A.; Kawahata, I.; Wang, Y.; Jia, W.; Sekimori, T.; Chen, Y.; Stefanova, N.; Finkelstein, D. I.; Ma, W.; Chen, M.; Sasaki, T.; Fukunaga, K.
10.1101/2022.06.16.496509 — pathology — Posted on 2022-09-28
573 HMMploidy: inference of ploidy levels from short-read sequencing data
Soraggi, S.; Rhodes, J.; Altinkaya, I.; Tarrant, O.; Balloux, F.; Fisher, M. C.; Fumagalli, M.
10.1101/2021.06.29.450340 — bioinformatics — Posted on 2022-09-27
578 Tyramine and its AmTYR1 receptor modulate attention in honey bees (Apis mellifera)
Latshaw, J. S.; Mazade, R. E.; Petersen, M.; Mustard, J. A.; Sinakevitch, I.; Wissler, L.; Guo, X.; Cook, C. N.; Lei, H.; Gadau, J.; Smith, B. H.
10.1101/2022.09.02.506392 — animal behavior and cognition — Posted on 2022-09-28
580 CorA gene rearrangement triggered the salinity-driven speciation of Poseidoniales
Fan, L.; Xu, B.; Chen, S.; Liu, Y.; Li, F.; Xie, W.; Prabhu, A.; Zou, D.; Wan, R.; Li, H.; Liu, H.; Liu, Y.; Kao, S.-J.; Chen, J.; Zhu, Y.; Rinke, C.; Li, M.; Zhang, C.
10.1101/2022.09.25.509439 — evolutionary biology — Posted on 2022-09-27
582 Hummingbird blood traits track oxygen availability across space and time
Williamson, J. L.; Linck, E. B.; Bautista, E.; Smiley, A.; McGuire, J. A.; Dudley, R.; Witt, C. C.
10.1101/2022.01.18.476833 — evolutionary biology — Posted on 2022-09-28
583 A self-blinking DNA probe for live-cell 3D imaging of native chromatin
ZHENG, Y.; Ye, S.; Li, S.; Liu, C.; Luo, S.; Chen, Y.; Li, Y.; Huang, L.; Deng, S.; Chen, P.; Zhang, Y.; Ji, W.; Luo, R.; Li, G.; Yang, D.
10.1101/2022.06.22.497271 — cell biology — Posted on 2022-09-28
584 A novel, ssDNA Bidnavirus in the giant freshwater prawn Macrobrachium rosenbergii
Gangnonngiw, W.; Bunnontae, M.; Kayansamruaj, P.; Senapin, S.; Srisala, J.; Flegel, T. W.; Wongprasert, K.
10.1101/2022.09.25.509311 — microbiology — Posted on 2022-09-27
590 ModelRevelator: Fast phylogenetic model estimation via deep learning
Burgstaller-Muehlbacher, S.; Crotty, S. M.; Schmidt, H. A.; Drucks, T.; von Haeseler, A.
10.1101/2021.12.22.473813 — evolutionary biology — Posted on 2022-09-27
592 SARS-CoV-2 variants show temperature-dependent enhancedpolymerase activity in the upper respiratory tract and high transmissibility
Kim, S.-M.; Kim, E.-H.; Casel, M. A. B.; Kim, Y.-i.; Sun, R.; Kwack, M.-J.; Yoo, J.-S.; Yoo, M.-A.; Yoo, K.-M.; Jang, S.-G.; Rollon, R.; Choi, J. H.; Gil, J.; Eun, K.; Kim, H.; Ensser, A.; Hwang, J.; Song, M.-S.; Kim, M. H.; Jung, J. U.; Choi, Y. K.
10.1101/2022.09.27.509689 — microbiology — Posted on 2022-09-27
594 Spatiotemporally resolved transcriptomics reveals subcellular RNA kinetic landscape
Ren, J.; Zhou, H.; Zeng, H.; Wang, C. K.; Huang, J.; Qiu, X.; Maher, K.; Lin, Z.; He, Y.; Tang, X.; Li, B.; Liu, J.; Wang, X.
10.1101/2022.09.27.509606 — genomics — Posted on 2022-09-27
597 Wild red deer (Cervus elaphus) do not play a role as vectors or reservoirs of SARS-CoV-2 in north-eastern Poland.
Krupinska, M.; Borkowski, J.; Goll, A.; Nowicka, J.; Baranowicz, K.; Bourret, V.; Strandin, T.; Maki, S.; Kant, R.; Sironen, T.; Grzybek, M.
10.1101/2022.09.27.509682 — microbiology — Posted on 2022-09-27
601 Cross-species predictive modeling reveals conserved drought responses between maize and sorghum
Pardo, J.; Wai, C. M.; Harman, M.; Nguyen, A.; Kremling, K. A.; Romay, C.; Lepak, N.; Bauerle, T. L.; Buckler, E. S.; Thompson, A. M.; VanBuren, R.
10.1101/2022.09.26.509573 — plant biology — Posted on 2022-09-27
602 Genome-scale mRNA transcriptomic insights into the mature growth dynamic of Cigar tobacco leaves
Yang, J.; Wan, D.; Qiao, B.; Yu, J.; Li, Z.; Liu, D.; Lv, P.; Hu, J.; Rao, X.; Xu, F.; wang, s.; Yang, C.
10.1101/2022.09.26.509548 — plant biology — Posted on 2022-09-27
604 DepLink: an R Shiny app to systematically link genetic and pharmacologic dependencies of cancer
Nayak, T.; Wang, L.-J.; Ning, M.; Rubannelsonkumar, G.; Jin, E.; Zheng, S.; Houghton, P. J.; Huang, Y.; Chiu, Y.-C.; Chen, Y.
10.1101/2022.09.26.509353 — bioinformatics — Posted on 2022-09-27
610 Molecular genetics of GLUT1DS Italian pediatric cohort: 10 novel related-disease variants and structural analysis
Mauri, A.; Duse, A.; Palm, G.; Previtali, R.; Bova, S. M.; Olivotto, S.; Benedetti, S.; Coscia, F.; Veggiotti, P.; Cereda, C.
10.1101/2022.09.26.509448 — genetics — Posted on 2022-09-27
613 Integrated Model of the Vertebrate Augmin Complex
Travis, S. M.; Mahon, B. P.; Huang, W.; Ma, M.; Rale, M. J.; Kraus, J. S.; Taylor, D.; Zhang, R.; Petry, S.
10.1101/2022.09.26.509603 — molecular biology — Posted on 2022-09-27
614 Venom protection by antibody from a snakebite hyperimmune subject
Glanville, J.; Andrade, J. C.; Bellin, M.; Kim, S.; Pletnev, S.; Tsao, D.; Verardi, R.; Bedi, R.; Friede, T.; Liao, S.; Newland, R.; Bayless, N. L.; Youssef, S.; Tully, E.; Zhang, B.; Bylund, T.; Kim, S.; Liu, T.; Kwong, P. D.
10.1101/2022.09.26.507364 — immunology — Posted on 2022-09-27
615 Prototyping of a lateral flow assay based on monoclonal antibodies for detection of Bothrops venoms
Knudsen, C.; Jürgensen, J. A.; Knudsen, P. D.; Oganesyan, I.; Harrison, J. A.; Dam, S. H.; Haack, A. M.; Friis, R. U. W.; Belfakir, S. B.; Ross, G. M. S.; Zenobi, R.; Laustsen, A. H.
10.1101/2022.09.26.509137 — immunology — Posted on 2022-09-27
616 The promiscuous development of an unconventional Qa1b-restricted T cell population
Manoharan Valerio, M. A.; Arana, K.; Guan, J.; Wei Chan, S.; Kurd, N. S.; Lee, A.; Shastri, N.; Robey, E.
10.1101/2022.09.26.509583 — immunology — Posted on 2022-09-27
617 Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies
Perrett, H. R.; Brouwer, P. J. M.; Hurtado, J.; Newby, M. L.; Burger, J. A.; Liu, L.; Bouhuijs, J. H.; Gibson, G.; Messmer, T.; Schieffelin, J. S.; Antanasijevic, A.; Boons, G.-J.; Crispin, M.; Sanders, R. W.; Briney, B.; Ward, A. B.
10.1101/2022.09.26.509601 — immunology — Posted on 2022-09-27
618 Clinical, socio-demographic, and parental correlates of early autism traits
Gale-Grant, O.; Chew, A.; Falconer, S.; Franca, L. G. S.; Fenn-Moltu, S.; Hadaya, L.; Harper, N.; Ciarrusta, J.; Charman, T.; Murphy, D.; Arichi, T.; McAlonan, G.; Nosarti, C.; Edwards, D.; Batalle, D.
10.1101/2022.09.26.508121 — neuroscience — Posted on 2022-09-27
621 Targeting neuroinflammatory pathways using Nanoligomer is neuroprotective in prion disease
Risen, S. J.; Boland, S.; Sharma, S.; Weismann, G.; Shirley, P.; Hines, A. D.; Hay, A. J. D.; McGrath, S.; Chatterjee, A.; Nagpal, P.; Moreno, J. A.
10.1101/2022.09.26.509513 — neuroscience — Posted on 2022-09-27
622 EEG-neurofeedback for promoting neuromodulation in the elderly: evidence from a double-blind study
Andrade, K.; Guieysse, T.; Razafimahatratra, S.; Houmani, N.; Klarsfeld, A.; Dreyfus, G.; Dubois, B.; Medani, T.; Vialatte, F.
10.1101/2022.09.26.509227 — neuroscience — Posted on 2022-09-27
625 Preserved neural population dynamics across animals performing similar behaviour
Safaie, M.; Chang, J. C.; Park, J.; Miller, L. E.; Dudman, J. T.; Perich, M. G.; Gallego, J. A.
10.1101/2022.09.26.509498 — neuroscience — Posted on 2022-09-27
630 Substrate-binding Glycine Residues are Major Determinants for Hydrolase and Ligase Activity of Plant Legumains
Hemu, X.; Chan, N.-Y.; Liew, H. T.; Hu, S.; Zhang, X.; Serra, A.; Lescar, J.; Liu, C.-F.; Tam, J. P.
10.1101/2022.09.26.509423 — plant biology — Posted on 2022-09-27
631 Mapping of the bs5 and bs6 non-race-specific recessive resistances against bacterial spot of pepper
Sharma, A.; Li, J.; Wente, R.; Minsavage, G. V.; Gill, U. S.; Ortega, A.; Vallejos, C. E.; Hart, J. P.; Staskawicz, B. J.; Mazourek, M. R.; Stall, R. E.; Jones, J. B.; Hutton, S. F.
10.1101/2022.09.26.509408 — plant biology — Posted on 2022-09-27
633 Prorenin from renal tubules is a major driver of diabetic kidney disease
Federlein, A.; Lehrmann, C.; Tauber, P.; Todorov, V. T.; Schweda, F.
10.1101/2022.09.26.509473 — physiology — Posted on 2022-09-27
636 ROCKETS - a novel one-for-all toolbox for light sheet microscopy in drug discovery
Mueller, J. P.; Dobosz, M.; O'Brien, N.; Giusti, A. M.; Lechmann, M.; Osl, F.; Wolf, A.-K.; Sauer, M.; Herting, F.; Umana, P.; Poeschinger, T.; Beilhack, A.
10.1101/2022.09.26.509149 — pharmacology and toxicology — Posted on 2022-09-27
638 Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS/AML
Wheeler, E. C.; Martin, B. J. E.; Doyle, W. C.; Gorelov, R. A.; Donahue, M.; Jann, J. C.; Abdel-Wahab, O.; Taylor, J.; Seiler, M.; Buonamici, S.; Belizaire, R.; Adelman, K.; Tothova, Z.
10.1101/2022.09.26.509430 — cancer biology — Posted on 2022-09-27
641 Optical Biopsy using a neural network to predict functional state from photos of wounds
Teague, J.; Socia, D.; An, G.; Johnson, S.; Badylak, S.; Vodovotz, Y.; Jiang, P.; Cockrell, C.
10.1101/2022.09.26.509543 — bioinformatics — Posted on 2022-09-27
642 Engineering Alignment has Mixed Effects on hiPSC-CM Maturation
Kalkunte, N.; Delambre, T.; Sohn, S.; Pickett, M.; Parekh, S. H.; Zoldan, J.
10.1101/2022.09.26.509194 — bioengineering — Posted on 2022-09-27
643 3D Bioelectronics with a Remodellable Matrix for Long-term Tissue Integration and Recording
Boys, A. J.; Carnicer Lombarte, A.; Guemes Gonzalez, A.; van Niekerk, D. C.; Hilton, S.; Barone, D. G.; Proctor, C. M.; Owens, R. M.; Malliaras, G. G.
10.1101/2022.09.26.509464 — bioengineering — Posted on 2022-09-27
644 Residual Complex I activity supports glutamate catabolism and mtSLP via canonical Krebs cycle activity during acute anoxia without OXPHOS
Ravasz, D.; Bui, D.; Nazarian, S.; Pallag, G.; Karnok, N.; Roberts, J.; Tennant, D. A.; Greenwood, B.; Kitayev, A.; Hill, C.; Komlodi, T.; Doerrier, C.; Gnaiger, E.; Kiebish, M. A.; Raska, A.; Kolev, K.; Czumbel, B.; Narain, N. R.; Seyfried, T. N.; Chinopoulos, C.
10.1101/2022.09.26.509156 — biochemistry — Posted on 2022-09-27
645 Alendronate Conjugate for Targeted Delivery to Bone-Forming Prostate Cancer
Damasco, J.; Yu, G.; Kumar, A.; Lirag, R. C.; Whitley, E.; Lin, S.-H.; Melancon, M. P.
10.1101/2022.09.26.508175 — biochemistry — Posted on 2022-09-27
646 Ten new high-quality genome assemblies for diverse bioenergy sorghum genotypes
Voelker, W. G.; Krishnan, K.; Chougule, K.; Alexander, L. C.; Lu, Z.; Olson, A.; Ware, D.; Songsomboon, K.; Ponce, C. M.; Brenton, Z.; Boatwright, J. L.; Cooper, E. A.
10.1101/2022.09.26.509520 — genomics — Posted on 2022-09-27
647 Resolution of structural variation in diverse mouse genomes reveals chromatin remodeling due to transposable elements
Ferraj, A.; Audano, P. A.; Balachandran, P.; Czechanski, A.; Flores, J. I.; Radecki, A. A.; Mosur, V.; Gordon, D. S.; Walawalkar, I. A.; Eichler, E. E.; Reinholdt, L. G.; Beck, C. R.
10.1101/2022.09.26.509577 — genomics — Posted on 2022-09-27
648 Investigating community formation through dense spatial and temporal sampling of 5-6th century cemeteries in Pannonia
Vyas, D. N.; Koncz, I.; Modi, A.; Mende, B. G.; Tian, Y.; Francalacci, P.; Lari, M.; Vai, S.; Straub, P.; Gallina, Z.; Szeniczey, T.; Hajdu, T.; Radzeviciute, R.; Hofmanova, Z.; Evinger, S.; Bernert, Z.; Pohl, W.; Caramelli, D.; Vida, T.; Geary, P. J.; Veeramah, K. R.
10.1101/2022.09.26.509582 — genetics — Posted on 2022-09-27
652 Population Structure and Migration in the Eastern Highlands of Papua New Guinea; a Region Impacted by the kuru Epidemic
Quinn, L.; Moltke, I.; Whitfield, J.; Alpers, M.; Campbell, T.; Hummerich, H.; Pomat, W.; Siba, P.; Koki, G.; Collinge, J.; Hellenthal, G.; Mead, S.
10.1101/2022.09.26.509478 — genetics — Posted on 2022-09-27
654 Deleterious effects of thermal and water stresses on life history and physiology: a case study on woodlouse
DEPEUX, C.; BRANGER, A.; MOULIGNIER, T.; MOREAU, J.; Lemaitre, J.-F.; DECHAUME-MONCHARMONT, F.-X.; LAVERRE, T.; PAULHAC, H.; GAILLARD, J.-M.; BELTRAN-BECH, S.
10.1101/2022.09.26.509512 — evolutionary biology — Posted on 2022-09-27
655 Widespread sympatry in a species-rich clade of marine fishes (Carangoidei)
Glass, J. R.; Harrington, R. C.; Cowman, P. F.; Faircloth, B. C.; Near, T. J.
10.1101/2022.09.26.509594 — evolutionary biology — Posted on 2022-09-27
658 Evolutionary history of Euteliidae (Lepidoptera, Noctuoidea)
Zahiri, R.; Holloway, J. D.; Rota, J.; Schmidt, C.; Pellinen, M. J.; Kitching, I. J.; Miller, S. E.; Wahlberg, N.
10.1101/2022.09.26.508383 — evolutionary biology — Posted on 2022-09-27
661 Fitting individual-based models of species range dynamics to long-term monitoring data
Malchow, A.-K.; Fandos, G.; Kormann, U.; Grüebler, M.; Kery, M.; Hartig, F.; Zurell, D.
10.1101/2022.09.26.509574 — ecology — Posted on 2022-09-27
662 A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice
Hackstein, C.-P.; Costigan, D.; Drexhage, L.; Pearson, C.; Bullers, S.; Ilott, N.; Akther, H. D.; Gu, Y.; FitzPatrick, M. E. B.; Harrison, O. J.; Garner, L. C.; Mann, E. H.; Pandey, S.; Friedrich, M.; Provine, N. M.; Uhlig, H.; Marchi, E.; Powrie, F.; Klenerman, P.; Thornton, E. E.
10.1101/2022.09.26.509581 — immunology — Posted on 2022-09-27
663 Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE following helminth infection
Curtiss, M. L.; Rosenberg, A. F.; Scharer, C. D.; Benavides, N. A. B.; Bradley, J. E.; Leon, B.; Steele, C. C.; Randall, T. D.; Lund, F. E.
10.1101/2022.09.26.507843 — immunology — Posted on 2022-09-27
665 Olfactory microvillar tuft cells direct neurogenesis during allergic inflammation
Ualiyeva, S.; Lemire, E. R.; Boyd, A.; Wong, C.; Aviles, E. C.; Maxfield, A.; Roditi, R.; Barett, N.; Barett, N.; Bucheit, K. M.; Laidlaw, T. M.; Boyce, J. A.; Bankova, L. G.; Haber, A. L.
10.1101/2022.09.26.509561 — immunology — Posted on 2022-09-27
666 A conserved role for stomatin domain genes in olfactory behavior
Liang, X.; Taylor, M.; Napier-Jameson, R.; Calovich-Benne, C.; Norris, A. D.
10.1101/2022.09.26.508537 — neuroscience — Posted on 2022-09-27
667 Personalized transcranial alternating current stimulation improves sleep quality: Initial Findings
Gurumoorthy, R.; Ayanampudi, V.; Kumar, V.; Krishnan, A.; Walker, M. P.; Ivry, R.; Knight, R. T.
10.1101/2022.09.26.509537 — neuroscience — Posted on 2022-09-27
668 Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation in a neprilysin-independent manner
Williams, D.; Yan, B. Q.; Wang, H.; Negm, L.; Sackmann, C.; Verkuyl, C.; Rezai-Stevens, V.; Eid, S.; Sato, C.; Watts, J. C.; Wille, H.; Schmitt-Ulms, G.
10.1101/2022.09.26.509540 — neuroscience — Posted on 2022-09-27
669 Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories
Sias, A. C.; Jafar, Y.; Goodpaster, C. M.; Ramirez-Armenta, K.; Wrenn, T. M.; Griffin, N. K.; Sharpe, M. J.; Wassum, K. M.
10.1101/2022.09.26.509602 — neuroscience — Posted on 2022-09-27
671 Conserved YKL-40 changes in mice and humans after postoperative delirium.
David-Bercholz, J.; Acker, L.; Caceres, A. I.; Wu, P. Y.; Goenka, S.; Franklin, N. O.; Rodriguiz, R. M.; Wetsel, W. C.; Devinney, M.; Wright, M. C.; Zetterberg, H.; Yang, T.; Berger, M.; Terrando, N.
10.1101/2022.09.26.509551 — neuroscience — Posted on 2022-09-27
677 Experience-dependent flexibility in a molecularly diverse central-to-peripheral auditory feedback system
Frank, M.; Sitko, A.; Suthakar, K.; Torres Cadenas, L.; Hunt, M.; Yuk, M. C.; Weisz, C.; Goodrich, L.
10.1101/2022.09.26.509230 — neuroscience — Posted on 2022-09-27
686 Tumour growth: Bayesian parameter calibration of a multiphase porous media model based on in vitro observations of Neuroblastoma spheroid growth in a hydrogel microenvironment
Hervas-Raluy, S.; Wirthl, B.; Guerrero, P. E.; Robalo Rei, G.; Nitzler, J.; Coronado, E.; Font de Mora, J.; Schrefler, B. A.; Gomez-Benito, M. J.; Garcia-Aznar, J. M.; Wall, W. A.
10.1101/2022.09.26.509452 — bioengineering — Posted on 2022-09-27
687 The elasto-plastic nano- and microscale compressive behaviour of rehydrated mineralised collagen fibres
Groetsch, A.; Gourrier, A.; Casari, D.; Schwiedrzik, J.; Shephard, J. D.; Michler, J.; Zysset, P. K.; Wolfram, U.
10.1101/2022.09.26.509461 — bioengineering — Posted on 2022-09-27
690 Structural foundations of potassium selectivity in channelrhodopsins
Govorunova, E. G.; Sineshchekov, O. A.; Brown, L.; Bondar, A.-N.; Spudich, J. L.
10.1101/2022.09.26.509509 — biochemistry — Posted on 2022-09-27
691 Programming super DNA-enzyme molecules for on-demand enzyme activity modulation
Zhao, H.; Xiu, X.; Li, M.; Gou, M.; Tao, L.; Zuo, X.; Fan, C.; Tian, Z.; Song, P.
10.1101/2022.09.26.509444 — biochemistry — Posted on 2022-09-27
693 Quartet RNA reference materials and ratio-based reference datasets for reliable transcriptomic profiling
Yu, Y.; Hou, W.; Wang, H.; Dong, L.; Liu, Y.; Sun, S.; Yang, J.; Cao, Z.; Zhang, P.; Zi, Y.; Li, Z.; Liu, R.; Gao, J.; Chen, Q.; Zhang, N.; Li, J.; Ren, L.; Jiang, H.; Shang, J.; Zhu, S.; Wang, X.; Qing, T.; Bao, D.; Li, B.; Li, B.; Suo, C.; Pi, Y.; Wang, X.; Dai, F.; Scherer, A.; Mattila, P.; Han, J.; Zhang, L.; Jiang, H.; Thierry-Mieg, D.; Thierry-Mieg, J.; Xiao, W.; Hong, H.; Tong, W.; Wang, J.; Li, J.; Fang, X.; Jin, L.; Shi, L.; Xu, J.; Qian, F.; Zhang, R.; Zheng, Y.
10.1101/2022.09.26.507265 — genetics — Posted on 2022-09-27
695 IL-12-expressing highly immunogenic recombinant modified vaccinia virus Ankara reprograms tumor-infiltrating myeloid cells to overcome immune resistance
Liu, S.; Mazo, G.; Yang, N.; Zhang, T.; Wang, Y.; Baseer Tariq, S.; Wang, Y.; Hirschhorn-Cymerman, D.; Ji, L.; Tan, A.; Wang, J.; Yan, W.; Choi, J.; Xiang, J. Z.; Li, M. O.; Merghoub, T.; Wolchok, J. D.; Deng, L.
10.1101/2022.09.25.509429 — immunology — Posted on 2022-09-27
696 Biochemical and metabolic maladaption defines pathological niches in progressive multiple sclerosis
Grant-Peters, M.; Rich-Griffin, C.; Yeung, H.-Y.; Thomas, T.; Davis, S.; Azizian, M.; Fisher, J.; Fischer, R.; Cinque, G. A.; Dendrou, C. A.
10.1101/2022.09.26.509462 — neuroscience — Posted on 2022-09-27
702 Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks
Liebe, S.; Niediek, J.; Pals, M.; Reber, T. P.; Faber, J.; Bostroem, J.; Elger, C. E.; Macke, J. H.; Mormann, F.
10.1101/2022.09.25.509370 — neuroscience — Posted on 2022-09-27
707 Gene panel design for spatial transcriptomics with prioritized gene sets
Yafi, M. A.; Hisham, M. H. H.; Grisanti, F.; Rahman, A.; Samee, M. A. H.
10.1101/2022.09.25.509418 — bioinformatics — Posted on 2022-09-27
715 CorA gene rearrangement triggered the salinity-driven speciation of Poseidoniales
Fan, L.; Xu, B.; Chen, S.; Liu, Y.; Li, F.; Xie, W.; Prabhu, A.; Zou, D.; Wan, R.; Li, H.; Liu, H.; Liu, Y.; Kao, S.-J.; Chen, J.; Zhu, Y.; Rinke, C.; Li, M.; Zhang, C.
10.1101/2022.09.25.509439 — evolutionary biology — Posted on 2022-09-27
717 Gut bacteria-derived serotonin promotes immune tolerance in early life
Sanidad, K. Z.; Rager, S. L.; Ananthanarayanan, A.; Callaghan, R.; Li, T.; Brown, J. A.; Amir, M.; Jin, J. L.; Savage, A. R.; Luo, R.; Mardorsky Rowdo, F.; Martin, M. L.; Silver, R. B.; Artis, D.; Guo, C.-J.; Krumsiek, J.; Inohara, N.; Zeng, M. Y.
10.1101/2022.09.25.509428 — immunology — Posted on 2022-09-27
718 Impact of cellular prion protein expression on disease progression and pathology in two mouse models of Alzheimer's disease
Purro, S. A.; Farmer, M.; Noble, E.; Sarell, C. J.; Powell, M.; Yip, D. C.-M.; Giggins, L.; Zakka, L.; Thomas, D. X.; Farrow, M. A.; Nicoll, A. J.; Walsh, D. M.; Collinge, J.
10.1101/2022.09.25.508690 — neuroscience — Posted on 2022-09-27
726 IMPatienT: an Integrated web application to digitize, process and explore Multimodal PATIENt daTa.
Meyer, C.; Romero, N.; Evangelista, T.; Cadot, B.; Laporte, J.; Jeannin-Girardon, A.; Collet, P.; Chennen, K.; Poch, O.
10.1101/2022.04.08.487635 — bioinformatics — Posted on 2022-09-27
729 Rapid reductions in population size drive evolutionary divergence in diatoms
Walworth, N. G.; Espinoza, J. L.; Argyle, P. A.; Hinners, J.; Levine, N. M.; Doblin, M. A.; Dupont, C. L.; Collins, S.
10.1101/2022.09.25.509407 — evolutionary biology — Posted on 2022-09-27
734 Thalamic volume and functional connectivity are associated with nicotine dependence severity and craving
Lor, C. S.; Haugg, A.; Zhang, M.; Schneider, L.; Herdener, M.; Quednow, B. B.; Golestani, N.; Scharnowski, F.
10.1101/2022.09.25.509385 — neuroscience — Posted on 2022-09-27
735 "Primed to Perform:" Dynamic white matter graph communicability may drive metastable network representations of enhanced preparatory cognitive control
Buch, V. P.; Bernabei, J. M.; Ng, G. Y.; Richardson, A. G.; Ramayya, A.; Brandon, C.; Stiso, J.; Bassett, D. S.; Lucas, T. H.
10.1101/2022.09.25.509351 — neuroscience — Posted on 2022-09-27
737 Population Genomics of Stone Age Eurasia
Allentoft, M. E.; Sikora, M.; Refoyo-Martinez, A.; Irving-Pease, E. K.; Fischer, A.; Barrie, W.; Ingason, A.; Stenderup, J.; Sjögren, K.-G.; Pearson, A.; Sousa da Mota, B.; Paulsson, B. S.; Halgren, A. S.; Macleod, R.; Schjellerup Jorkov, M. L.; Demeter, F.; Novosolov, M.; Sorensen, L.; Nielsen, P. O.; Henriksen, R. A.; Vimala, T.; McColl, H.; Margaryan, A.; Ilardo, M.; Vaughn, A.; Mortensen, M. F.; Nielsen, A. B.; Hede, M. U.; Rasmussen, P.; Vinner, L.; Renaud, G.; Stern, A. J.; Trolle Jensen, T. Z.; Johannsen, N. N.; Scorrano, G.; Schroeder, H.; Lysdahl, P.; Ramsoe, A.; Skorobogatov, A.; Sc
10.1101/2022.05.04.490594 — evolutionary biology — Posted on 2022-09-27
739 Evolution of immune genes in island birds: reduction in population sizes can explain island syndrome
Barthe, M.; Doutrelant, C.; Covas, R.; Melo, M.; Illera, J. C.; Tilak, M.-K.; Colombier, C.; Leroy, T.; Loiseau, C.; Nabholz, B.
10.1101/2021.11.21.469450 — evolutionary biology — Posted on 2022-09-27
743 HSP70-binding motifs function as protein quality control degrons
Abildgaard, A. B.; Voutsinos, V.; Petersen, S. D.; Larsen, F. B.; Kampmeyer, C.; Johansson, K. E.; Stein, A.; Ravid, T.; Andreasson, C.; Jensen, M. K.; Lindorff-Larsen, K.; Hartmann-Petersen, R.
10.1101/2021.12.22.473789 — biochemistry — Posted on 2022-09-27
747 Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair
Daboussi, L.; Costaguta, G.; Gullo, M.; Pessino, V.; O'Leary, B.; Lettieri, K.; Driscoll, S.; Pfaff, S. L.
10.1101/2022.09.25.509350 — neuroscience — Posted on 2022-09-27
753 Seasonality of host-seeking Ixodes ricinus nymph abundance in relation to climate
Hoch, T.; Madouasse, A.; Jacquot, M.; Wongnak, P.; Beugnet, F.; Bournez, L.; Huard, F.; Moutailler, S.; Plantard, O.; Poux, V.; Rene-Martellet, M.; Vayssier-Taussat, M.; Verheyden, H.; Vourc'h, G.; Chalvet-Monfray, K.; Agoulon, A.
10.1101/2022.07.25.501416 — ecology — Posted on 2022-09-27
755 3D Ground Truth Annotations of Nuclei in 3D Microscopy Volumes
Chen, A.; Wu, L.; Winfree, S.; Dunn, K. W.; Salama, P.; Delp, E. J.
10.1101/2022.09.26.509542 — cell biology — Posted on 2022-09-26
757 Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo movement
Tirumala, N. A.; Redpath, G. M. I.; Kapoor-Kaushik, N.; Ariotti, N.; Dolai, P.; Kumar, K. V.; Ananthanarayanan, V.
10.1101/2021.04.05.438428 — cell biology — Posted on 2022-09-27
758 Septins regulate border cell shape and surface geometry downstream of Rho
Gabbert, A. M.; Mondo, J.; Campanale, J. P.; Mitchell, N. P.; Myers, A.; Streichan, S. J.; Miolane, N.; Montell, D. J.
10.1101/2021.04.08.439079 — cell biology — Posted on 2022-09-27
759 Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics
Zhang, D.; Lape, R.; Shaikh, S. A.; Kohegyi, B. K.; Watson, J. F.; Cais, O.; Nakagawa, T.; Greger, I. H.
10.1101/2022.09.25.509219 — neuroscience — Posted on 2022-09-26
760 Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells
Parylak, S. L.; Qiu, F.; Linker, S. B.; Gallina, I. S.; Lim, C. K.; Preciado, D.; McDonald, A. H.; Gage, F. H.
10.1101/2022.09.26.508896 — neuroscience — Posted on 2022-09-26
761 Ultrastructure of synaptic connectivity within sub-regions of the SCN revealed by genetically encoded EM tag and SBEM
Calligaro, H.; Shoghi, A.; Chen, X.; Kim, K.-Y.; Liu, Y. H.; Khov, B.; Finander, B.; Le, H.; Ellisman, M. H.; Panda, S.
10.1101/2022.09.26.509467 — neuroscience — Posted on 2022-09-26
762 A positively tuned voltage indicator reveals electrical correlates of calcium activity in the brain
Evans, S. W.; Shi, D.; Chavarha, M.; Plitt, M. H.; Taxidis, J.; Madruga, B.; Fan, J. L.; Hwang, F.-J.; Van Keulen, S. C.; Suomivuori, C.-M.; Pang, M.; Su, S.; Zhang, G.; Lee, S.; Jiang, D.; Pradhan, L.; Liu, Y.; Reese, A.; Negrean, A.; Losonczy, A.; Makinson, C. D.; Wang, S.; Clandinin, T.; Dror, R.; Ding, J. B.; Ji, N.; Golshani, P.; Giocomo, L. M.; Bi, G. G.; Lin, M. Z.
10.1101/2021.10.21.465345 — neuroscience — Posted on 2022-09-27
763 SCF-FBXW7 regulates G2-M progression through control of CCNL1 ubiquitination
O'Brien, S.; Kelso, S.; Steinhart, Z.; Orlicky, S.; Mis, M.; Kim, Y.; Lin, S.; Sicheri, F.; Angers, S.
10.1101/2022.09.26.509608 — cancer biology — Posted on 2022-09-26
764 Circadian rhythm orthologs drive pulses of heterochronic miRNA transcription in C. elegans
Kinney, B.; Sahu, S.; Stec, N.; Hills-Muckey, K.; Adams, D.; Wang, J.; Jaremako, M.; Joshua-Tor, L.; Keil, W.; Hammell, C. M.
10.1101/2022.09.26.509508 — developmental biology — Posted on 2022-09-26
765 A tissue-specific ubiquitin switch coordinates brain, craniofacial, and skin development
Asmar, A. J.; Yazejian, R. M.; Wu, Y.; Collins, J. C.; Hsin, J.; Cho, J.; Doyle, A. D.; Cinthala, S.; Simon, M.; van Jaarsveld, R. H.; Beck, D. B.; Kerosuo, L.; Werner, A.
10.1101/2022.09.26.509591 — developmental biology — Posted on 2022-09-26
766 Transposase N-terminal phosphorylation and asymmetric transposon ends inhibit piggyBac transposition in mammalian cells
Luo, W.; Hickman, A.; Genzor, P.; Ghirlando, R.; Furman, C. M.; Menshikh, A.; Haase, A. D.; Dyda, F.; Wilson, M. H.
10.1101/2022.09.26.509586 — molecular biology — Posted on 2022-09-26
768 Moving Beyond Processing and Analysis-Related Variation in Neuroscience
Li, X.; Ai, L.; Giavasis, S.; Jin, H.; Feczko, E.; Xu, T.; Clucas, J.; Franco, A.; Heinsfeld, A. S.; Adebimpe, A.; Vogelstein, J. T.; Yan, C.-G.; Esteban, O.; Poldrack, R. A.; Craddock, C.; Fair, D.; Satterthwaite, T.; Kiar, G.; Milham, M. P.
10.1101/2021.12.01.470790 — neuroscience — Posted on 2022-09-26
769 Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity
Arroyo, J. P.; Terker, A. S.; Zuchowski, Y.; Watts, J. A.; Bock, F.; Meyer, C.; Luo, W.; Kapp, M. E.; Gould, E. R.; Jiang, M.; Miranda, A. X.; Jiang, M.; Vanacore, R.; Hammock, E.; Wilson, M.; Zent, R.; Zhang, M.-Z.; Bhave, G.; Harris, R. C.
10.1101/2022.05.13.491898 — physiology — Posted on 2022-09-26
771 Reprogramming Adeno-Associated Virus Tropism Via Displayed Peptides Tiling Receptor-Ligands
Portell, A.; Ford, K. M.; Suhardjo, A.; Rainaldi, J.; Bublik, M. N.; Sanghvi, M.; Kumar, A.; Wing, M. K.; Palmer, N. D.; Le, D. A.; Kalahasti, N.; Dailamy, A.; Mali, P.
10.1101/2022.09.26.509383 — bioengineering — Posted on 2022-09-26
772 Biomimetic S-adenosylmethionine regeneration for nucleophilic and radical alkylation reactions and aminopropyltransfer
Gericke, L.; Karst, L. C.; Mhaindarkar, D.; Jahn, S.; Kuge, M.; Mohr, M. K. F.; Gagsteiger, J.; Cornelissen, N. V.; Wen, X.; Mordhorst, S.; Jessen, H.; Rentmeister, A.; Seebeck, F. P.; Layer, G.; Loenarz, C.; Andexer, J. N.
10.1101/2022.09.26.509380 — biochemistry — Posted on 2022-09-26
773 Complex scaffold remodeling in plant triterpene biosynthesis
De La Pena, R.; Hodgson, H.; Liu, J. C. T.; Stephenson, M. J.; Martin, A. C.; Owen, C.; Harkess, A.; Leebens-Mack, J.; Jimenez, L. E.; Osbourn, A.; Sattely, E. S.
10.1101/2022.09.26.509531 — biochemistry — Posted on 2022-09-26
774 An Aurora B-RPA signaling axis secures chromosome segregation fidelity
Roshan, P.; Kuppa, S.; Mattice, J.; Kaushik, V.; Chadda, R.; Pokhrel, N.; Tumala, B.; Bothner, B.; Antony, E.; Origanti, S.
10.1101/2022.09.26.509563 — biochemistry — Posted on 2022-09-26
776 The Role of EBP50 in Regulating Endothelial-To-Mesenchymal Transition in Pulmonary Hypertension
Gorelova, A.; Berman, M.; Sharifi-Sanjani, M.; Pulgarin Rocha, A.; Alsuraimi, A.; Riva, P.; Negi, V.; Bertero, T.; Goncharov, D.; Kudryashova, T.; Dosunmu-Ogunbi, A.; Rajaratnam, A.; Harvey, L.; Nouraie, M.; Baust, J.; Bachman, T.; Sembrat, J.; Vargas, S. O.; Waxman, A. B.; Saggar, R.; Kumar, R.; Graham, B.; Straub, A. C.; Goncharova, E. A.; Mora, A.; Chan, S. Y.; Al Ghouleh, I.
10.1101/2022.05.31.494181 — cell biology — Posted on 2022-09-26
782 Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile
Olaitan, A. O.; Dureja, C.; Youngblom, M.; Topf, M. A.; Shen, W.-J.; Gonzales-Luna, A. J.; Deshpande, A.; Hevener, K. E.; Freeman, J.; Wilcox, M. H.; Palmer, K. L.; Garey, K. W.; Pepperell, C. S.; Hurdle, J. G.
10.1101/2022.09.23.509282 — microbiology — Posted on 2022-09-26
784 Group B Streptococcus Adaptation Promotes Survival in a Hyper-inflammatory Diabetic Wound Environment
Keogh, R. A.; Haeberle, A. L.; Langouët-Astrie, C. J.; Kavanaugh, J. S.; Schmidt, E. P.; Moore, G. D.; Horswill, A. R.; Doran, K. S.
10.1101/2022.06.27.497804 — microbiology — Posted on 2022-09-26
786 Queuosine modification of tRNA-Tyrosine elicits translational reprogramming and enhances growth of Vibrio cholerae with aminoglycosides.
Fruchard, L.; Babosan, A.; Carvalho, A.; Lang, M.; Li, B.; Duchateau, M.; Giai Gianetto, Q.; Matondo, M.; Bonhomme, F.; Fabret, C.; NAMY, O.; de Crecy-Lagard, V.; Mazel, D.; Baharoglu, Z.
10.1101/2022.09.26.509455 — microbiology — Posted on 2022-09-26
788 Cluster-driven evolution and modularity uncover paths of cholera emergence
Lopez-Perez, M.; Grant, T.-A.; Haro-Moreno, J. M.; Zaragoza-Solas, A.; Almagro-Moreno, S.
10.1101/2022.09.26.509565 — microbiology — Posted on 2022-09-26
789 Prioritized single-cell proteomics reveals molecular and functional polarization across primary macrophages
Huffman, R. G.; Leduc, A.; Wichmann, C.; di Gioia, M.; Borriello, F.; Specht, H.; Derks, J.; Khan, S.; Khoury, L.; Emmott, E.; Petelski, A. A.; Perlman, D. H.; Cox, J.; Zanoni, I.; Slavov, N.
10.1101/2022.03.16.484655 — immunology — Posted on 2022-09-26
790 A repertoire of foraging decision variables in the mouse brain
Cazettes, F.; Mazzucato, L.; Murakami, M.; Morais, J. P.; Renart, A.; Mainen, Z.
10.1101/2021.04.01.438090 — neuroscience — Posted on 2022-09-26
791 EMC10 reduction in human neurons and adult mouse brain rescues cellular and behavioral deficits linked to 22q11.2 deletion
Thakur, P.; Lackinger, M.; Diamantopoulou, A.; Rao, S.; Chen, Y.; Ferng, A.; Mazur, C.; Kordasiewicz, H.; Shprintzen, R. J.; Markx, S.; Xu, B.; Gogos, J. A.
10.1101/2022.03.01.482495 — neuroscience — Posted on 2022-09-26
792 Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism
Bridi, M.; Luo, N.; Kim, G.; O'Ferrall, C.; Oatel, R.; Bertrand, S.; Kannan, S.; Kirkwood, A.
10.1101/2021.07.05.451213 — neuroscience — Posted on 2022-09-26
793 A reference induced pluripotent stem cell line for large-scale collaborative studies
Pantazis, C. B.; Yang, A.; Lara, E.; McDonough, J. A.; Blauwendraat, C.; Peng, L.; Oguro, H.; Kanaujiya, J.; Zou, J.; Sebesta, D.; Pratt, G.; Cross, E.; Blockwick, J.; Buxton, P.; Kinner-Bibeau, L.; Medura, C.; Tompkins, C.; Hughes, S.; Santiana, M.; Faghri, F.; Nalls, M. A.; Vitale, D.; Ballard, S.; Qi, Y. A.; Ramos, D. M.; Anderson, K. M.; Stadler, J.; Narayan, P.; Papademetriou, J.; Reilly, L.; Nelson, M. P.; Aggarwal, S.; Rosen, L. U.; Kirwan, P.; Pisupati, V.; Coon, S. L.; Scholz, S. W.; Priebe, T.; Öttl, M.; Dong, J.; Meijer, M.; Janssen, L. J. M.; Lourenco, V. S.; van der Kant, R.; Cru
10.1101/2021.12.15.472643 — neuroscience — Posted on 2022-09-26
795 Structure-based identification of novel histone deacetylase 4 (HDAC4) inhibitors
Agarwal, R.; Pattarawat, P.; Duff, M. R.; Wang, H.-C. R.; Baudry, J.; Smith, J.
10.1101/2022.05.31.494169 — cancer biology — Posted on 2022-09-26
798 Rapid adaptation and range expansion in response to agriculture over the last two centuries
Kreiner, J. M.; Latorre, S. M.; Burbano, H. A.; Stinchcombe, J. R.; Otto, S. P.; Weigel, D.; Wright, S. I.
10.1101/2022.02.25.482047 — evolutionary biology — Posted on 2022-09-26
799 The single Marchantia polymorpha FERONIA homolog reveals an ancestral role in regulating cellular expansion and integrity
Mecchia, M. A.; Rovekamp, M.; Giraldo-Fonseca, A.; Meier, D.; Gadient, P.; Vogler, H.; Limacher, D.; Bowman, J.; Grossniklaus, U.
10.1101/2020.12.23.424085 — evolutionary biology — Posted on 2022-09-26
802 A small molecule that inhibits the evolution of antibiotic resistance
Johnson, A. E.; Bracey, H.; Viera, A. J. H.; Carvajal-Garcia, J.; Simsek, E. N.; Kim, K.; Merrikh, H.
10.1101/2022.09.26.509600 — microbiology — Posted on 2022-09-26
804 Bacillus subtilis remains translationally active after CRISPRi-mediated replication initiation arrest
Munoz-Gutierrez, V.; Cornejo, F. A.; Schmidt, K.; Frese, C. K.; Halte, M.; Erhardt, M.; Elsholz, A. K. W.; Turgay, K.; Charpentier, E.
10.1101/2022.09.20.508806 — microbiology — Posted on 2022-09-26
805 The population-level impact of Enterococcus faecalis genetics on intestinal colonisation and extraintestinal infection
Chaguza, C.; Pöntinen, A. K.; Top, J.; Arredondo-Alonso, S.; Freitas, A. R.; Novais, C.; Torres, C.; Bentley, S. D.; Peixe, L.; Coque, T. M.; Willems, R. J. L.; Corander, J.
10.1101/2022.09.26.509451 — microbiology — Posted on 2022-09-26
807 A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease
Avanzato, V. A.; Bushmaker, T.; Oguntuyo, K. Y.; Yinda, K. C.; Duyvesteyn, H. M. E.; Stass, R.; Meade-White, K.; Rosenke, R.; Thomas, T.; Saturday, G.; Doores, K. J.; Lee, B.; Bowden, T.; Munster, V.
10.1101/2022.09.26.507980 — microbiology — Posted on 2022-09-26
809 Thymic macrophages consist of two populations with distinct localization and origin
Zhou, T.-A.; Hsu, H.-P.; Tu, Y.-H.; Cheng, H.-K.; Lin, C.-Y.; Chen, N.-J.; Tsai, J.-W.; Robey, E. A.; Huang, H.-C.; Hsu, C.-L.; Dzhagalov, I. L.
10.1101/2021.11.04.467238 — immunology — Posted on 2022-09-26
810 Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses
Ambler, W. G.; Howlander, M.; Chalasani, M. L. S.; Seltzer, E.; Sim, J.; Shin, J.; Schwartz, N.; Shipman, W. D.; Dasoveanu, D.; Carballo, C.; Sevim, E.; Rodeo, S.; Erkan, D.; Kataru, R. P.; Mehrara, B.; Lu, T. T.
10.1101/2022.06.13.495930 — immunology — Posted on 2022-09-26
812 Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease
Schutzer Godoy, A.; Minalli Nakamura, A.; Douangamath, A.; Song, Y.; Dias Noske, G.; Oliveira Gawriljuk, V.; Sachetto Fernandes, R.; D. Muniz Pereira, H.; Irene Zagato Oliveira, K.; Fearon, D.; Dias, A.; Krojer, T.; Fairhead, M.; Powell, A.; Dunnet, L.; Brandao-Neto, J.; Skyner, R.; Chalk, R.; von Delft, F.; Bajusz, D.; Bege, M.; Borbas, A.; Miklos Keseru, G.; Oliva, G.
10.1101/2022.09.26.509485 — biochemistry — Posted on 2022-09-26
813 SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3
Schindewolf, C.; Lokugamage, K.; Vu, M.; Johnson, B. A.; Scharton, D.; Plante, J. A.; Kalveram, B. K.; Crocquet-Valdes, P. A.; Sotcheff, S. L.; Jaworski, E.; Alvarado, R. E.; Debbink, K.; Daugherty, M. D.; Weaver, S.; Routh, A. L.; Walker, D. H.; Plante, K. S.; Menachery, V. D.
10.1101/2022.09.26.509529 — microbiology — Posted on 2022-09-26
814 Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against Omicron
Chi, X.; Xia, L.; Zhang, G.; Chi, X.; Huang, B.; Zhang, Y.; Chen, Z.; Han, J.; Wu, L.; Li, Z.; Sun, H.; Huang, P.; Yu, C.; Chen, W.; Zhou, Q.
10.1101/2022.09.25.509344 — microbiology — Posted on 2022-09-26
816 Zymosan-induced leukocyte and cytokine changes in pigs: a new model for streamlined drug testing against severe COVID-19
Kokeny, G.; Bakos, T.; Barta, B. A.; Nagy, G. V.; Meszaros, T.; Kozma, G. T.; Szabo, A.; Szebeni, J.; Merkely, B.; Radovits, T.
10.1101/2022.09.23.509252 — immunology — Posted on 2022-09-26
817 Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis
Margaroli, C.; Benson, P.; Gastanadui, M. G.; Song, C.; Viera, L.; Xing, D.; Wells, J. M.; Patel, R.; Gaggar, A.; Payne, G. A.
10.1101/2022.09.25.509426 — pathology — Posted on 2022-09-26
818 High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike
Tan, T. J. C.; Mou, Z.; Lei, R.; Ouyang, W. O.; Yuan, M.; Song, G.; Andrabi, R.; Wilson, I. A.; Kieffer, C.; Dai, X.; Matreyek, K. A.; Wu, N. C.
10.1101/2022.09.24.509341 — biochemistry — Posted on 2022-09-26
819 Analysis of sex differential genes at whole genome level reveals their organ- and chromosome-dependent expressions, regulations, and interactions
Ma, J.; Wang, L.; Yuan, G.; Fernando, C.; Yao, L.; Dong, W.; Tian, C.; Bukiya, A.; Jablonski, M.; Feng, H.; Li, D.; Lu, L.; Jiao, Y.; Ji, J.; Wang, G.; Gu, W.
10.1101/2022.09.24.509319 — cell biology — Posted on 2022-09-26
820 EGFR-initiated endocytosis of Wnt9a and Fzd9b is required for β-catenin signaling
Nguyen, N.; Carpenter, K. A.; Thurlow, K. E.; Mu, E. M.; Gilliland, C.; Grainger, S.
10.1101/2022.09.25.509379 — cell biology — Posted on 2022-09-26
821 Sequencing of Monkeypox virus from infected patients reveals viral genomes with APOBEC3-like editing, gene inactivation, and bacterial agents of skin superinfection
Colson, P.; Penant, G.; Delerce, J.; Boschi, C.; Wurtz, N.; Branger, S.; Lagier, J.-C.; Cassir, N.; Tissot-Dupont, H.; Million, M.; Aherfi, S.; La Scola, B.
10.1101/2022.09.26.509493 — microbiology — Posted on 2022-09-26
822 A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta
Carter, B.; Huang, P.; Liu, G.; Liang, Y.; Lin, P. J. C.; Peng, B.-H.; McKay, L.; Dimitrakakis, A.; Hsu, J.; Tat, V.; Saenkham-Huntsinger, P.; Chen, J.; Kaseke, C.; Gaiha, G. D.; Xu, Q.; Griffiths, A.; Tam, Y. K.; Tseng, C.-T. K.; Gifford, D. K.
10.1101/2022.09.23.509206 — immunology — Posted on 2022-09-26
823 PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application
Zhang, Z.; Zhou, J.; Ni, P.; Hu, B.; Deng, S.; Xiao, Q.; He, Q.; Li, G.; Xia, Y.; Liu, M.; Wang, C.; Fang, Z.; Xia, N.; Zhang, Z.-R.; Zhang, B.; Cai, K.; Jolicoeur, N.; Xu, Y.; Liu, B.
10.1101/2022.09.26.509414 — immunology — Posted on 2022-09-26
825 Biophysical and Structural Characterization of a Viral Genome Packaging Motor
Prokhorov, N. S.; Davis, C. R.; Maruthi, K.; Yang, Q.; Woodson, M.; White, M. A.; Miller, L. M.; Jarrold, M. F.; Catalano, C. E.; Morais, M.
10.1101/2022.09.25.509378 — biophysics — Posted on 2022-09-26
827 Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes
Zhu, H.; Wang, G.; Nguyen-Ngoc, K.-V.; Kim, D.; Miller, M.; Goss, G.; Kovsky, J.; Harrington, A. R.; Saunders, D.; Melton, R.; Powers, A. C.; Preissl, S.; Spagnoli, F. M.; Gaulton, K. J.; Sander, M.
10.1101/2022.09.25.509355 — cell biology — Posted on 2022-09-26
831 Cryopreserved cGMP-compliant human pluripotent stem cells-derived immature hepatic progenitors rescue mice from acute liver failure
Gantier, M.; Rispal, R.; Angelique, F.; Menoret, S.; Delbos, F.; Renault, S.; Gary, A.-S.; Anegon, I.; Nguyen, T. H.
10.1101/2022.09.26.509491 — cell biology — Posted on 2022-09-26
833 Aging and Obesity Prime the Methylome and Transcriptome of Adipose Stem Cells for Disease and Dysfunction
Xie, S.; Choudhari, S.; Wu, C.-L.; Abramson, K.; Corcoran, D.; Gregory, S. G.; Thimmapuram, J. M.; Guilak, F.; Little, D.
10.1101/2022.09.26.509507 — cell biology — Posted on 2022-09-26
836 Dysregulation of Acid Ceramidase-mediated Sphingolipid Metabolism Contributes to Tumor Progression in Tuberous Sclerosis Complex
Astrinidis, A.; Li, C.; Zhang, E. Y.; Zhao, X.; Zhao, S.; Guo, M.; Huang, R.; Zhang, A. A.; Kopras, E. J.; Gupta, N.; Smith, E. P.; Fugate, E.; Lindquist, D.; Wikenheiser-Brokamp, K.; Setchell, K. D.; McCormack, F. X.; Xu, Y.; Yu, J. J.
10.1101/2022.09.25.509382 — cell biology — Posted on 2022-09-26
837 FLAIRR-seq: A novel method for single molecule resolution of near full-length immunoglobulin heavy chain repertoires
Ford, E. E.; Tieri, D.; Rodriguez, O. L.; Francoeur, N. J.; Soto, J.; Kos, J. T.; Gibson, W. S.; Silver, C. A.; Deikus, G.; Hudson, E.; Woolley, C. R.; Beckmann, N.; Charney, A.; Mitchell, T. C.; Sebra, R. P.; Watson, C. T.; Smith, M. L.
10.1101/2022.09.24.509352 — immunology — Posted on 2022-09-26
838 Involvement of superior colliculus in complex figure detection of mice
Cazemier, J. L.; Tran, T. K. L.; Hsu, A. T. Y.; Husic, M.; Kirchberger, L.; Self, M. W.; Roelfsema, P. R.; Heimel, J. A.
10.1101/2022.09.25.509365 — neuroscience — Posted on 2022-09-26
839 Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner
Kompotis, K.; Mang, G.; Hubbard, J. T.; Jimenez, S.; Emmenegger, Y.; Polysopoulos, C.; Hor, C. N.; Wigger, L.; Hebert, S. S.; Mongrain, V.; Franken, P.
10.1101/2022.09.24.508386 — neuroscience — Posted on 2022-09-26
841 Two cyclic electron flows around photosystem I differentially participate in C4 photosynthesis
Ogawa, T.; Kobayashi, K.; Taniguchi, Y. Y.; Shikanai, T.; Nakamura, N.; Yokota, A.; Munekage, Y. N.
10.1101/2022.09.23.509273 — plant biology — Posted on 2022-09-26
843 Preponderant Myosin Super-Relaxed State In Skeletal Muscle From Endurance Athletes
Lewis, C. T. A.; Tabrizian, L.; Nielsen, J.; Laitila, J.; Beck, T. N.; Aagaard, P.; Hokken, R.; Laugesen, S.; Ingersen, A.; Andersen, J. L.; Soendenbroe, C.; Helge, J. W.; Dela, F.; Larsen, S.; Sahl, R. E.; Roemer, T.; Hansen, M. T.; Frandsen, J.; Suetta, C.; Ochala, J.
10.1101/2022.09.23.509202 — physiology — Posted on 2022-09-26
849 Inter-organelle crosstalk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress
Metallo, C.; Kumar, A.; Kuna, R. S.; Galvez, H.; Wessendorf-Rodriguez, K. A.; Green, C. R.; McGregor, G. H.; Cordes, T.; Shaw, R. J.; Svensson, R. U.
10.1101/2022.09.24.509326 — bioengineering — Posted on 2022-09-26
850 EVIDENCE FOR EMPATHY IN PAIR BONDING POISON FROGS
Nowicki, J. P.; Rodriguez, C.; Lee, J. C.; Goolsby, B. C.; Yang, C.; Cleland, T. A.; O'Connell, L. A.
10.1101/2022.09.25.509360 — animal behavior and cognition — Posted on 2022-09-26
853 Viral proteins and virus-like particles of the LTR5_Hs endogenous retrovirus in human primordial germ cell-like cells
Kobayashi, M.; Kobayashi, M.; Kreuzer, J.; Zaniewski, E.; Kim, J. J.; Shioda, K.; Hagihara, H.; Odajima, J.; Nakashoji, A.; Zheng, Y.; Fu, J.; Ericsson, M.; Kawamura, K.; Stott, S. L.; Irimi, D.; Haas, W.; Wu, C.-L.; Tokuyama, M.; Shioda, T.
10.1101/2022.09.24.509338 — developmental biology — Posted on 2022-09-26
854 The carnitine shuttle links mitochondrial metabolism to histone acetylation and lipogenesis
Izzo, L. T.; Trefely, S.; Demetriadou, C.; Drummond, J.; Mizukami, T.; Kuprasertkul, N.; Farria, A.; Nguyen, P.; Reich, L.; Shaffer, J.; Affronti, H.; Carrer, A.; Andrews, A.; Capell, B. C.; Snyder, N. W.; Wellen, K. E.
10.1101/2022.09.24.509197 — cell biology — Posted on 2022-09-26
855 Engineering non-cytotoxic delivery of proteins by T cells via fusion to NPC2
Saeedi, A.; Bandey, I. N.; Leekha, A.; Fathi, M.; Rezvan, A.; Montalvo, M. J.; Wu, K.-L.; Bohat, R.; Peng, W.; Varadarajan, N.
10.1101/2022.09.24.509028 — immunology — Posted on 2022-09-26
856 Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model.
Liaudanskaya, V.; Fiore, N. J.; Zhang, Y.; Milton, Y.; Kelly, M. F.; Coe, M.; Barreiro, A.; Rose, V. K.; Shapiro, M. R.; Mullis, A. S.; Shevzov-Zebrun, A.; Blurton-Jones, M.; Whalen, M. J.; Symes, A. J.; Georgakoudi, I.; Nieland, T. J.; Kaplan, D. L.
10.1101/2022.09.23.509276 — neuroscience — Posted on 2022-09-26
862 Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes
Maitra, M.; Mitsuhashi, H.; Rahimian, R.; Chawla, A.; Yang, J.; Fiori, L.; Davoli, M.-A.; Perlman, K.; Aouabed, Z.; Mash, D. C.; Suderman, M.; Mechawar, N.; Turecki, G.; Nagy, C.
10.1101/2022.09.23.509254 — neuroscience — Posted on 2022-09-26
863 Microglia are involved in regulating histamine dependent and non-dependent itch transmissions with distinguished signal pathways
Yang, Y.; Mou, B.; Zhang, Q.-R.; Zhao, H.-X.; Zhang, J.-Y.; Yun, X.; Xiong, M.-T.; Liu, Y.; Liu, Y. U.; Pan, H.; Ma, C.-L.; Li, B.-M.; Peng, J.
10.1101/2022.09.23.498040 — neuroscience — Posted on 2022-09-26
867 Impact of clonal architecture on clinical course and prognosis in patients with myeloproliferative neoplasms
Luque Paz, D.; Bader, M. S.; Nienhold, R.; Rai, S.; Almeida Fonseca, T.; Stetka, J.; Hao-Shen, H.; Mild-Schneider, G.; Passweg, J. R.; Skoda, R. C.
10.1101/2022.09.24.509318 — cancer biology — Posted on 2022-09-26
873 3D-printed capillaric ELISA-on-a-chip with aliquoting
Parandakh, A.; Ymbern, O.; Jogia, W.; Renault, J.; Ng, A.; Juncker, D.
10.1101/2022.09.23.508398 — bioengineering — Posted on 2022-09-26
876 Global observation of plankton communities from space
Kaneko, H.; Endo, H.; Henry, N.; Berney, C.; Mahe, F.; Poulain, J.; Labadie, K.; Beluche, O.; El Hourany, R.; Tara Oceans Coordinators, ; Chaffron, S.; Wincker, P.; Nakamura, R.; Karp-Boss, L.; Boss, E.; Bowler, C.; de Vargas, C.; Tomii, K.; Ogata, H.; Acinas, S. G.; Babin, M.; Bork, P.; Cochrane, G.; Gorsky, G.; Guidi, L.; Grimsley, N.; Hingamp, P.; Iudicone, D.; Jaillon, O.; Kandels, S.; Karsenti, E.; Not, F.; Poulton, N.; Pesant, S.; Sardet, C.; Speich, S.; Stemmann, L.; Sullivan, M. B.; Sunagawa, S.
10.1101/2022.09.23.508961 — ecology — Posted on 2022-09-26
877 Multiplatform Modeling of Atrial Fibrillation Identifies Phospholamban as Central Regulator of Cardiac Rhythm
Colas, A.; Ocorr, K.; Grandi, E.; Andersen, P.; Kannan, S.; Spiering, S.; Yu, M.; Ni, H.; Kezos, J.; Kervadec, A.
10.1101/2022.09.23.509238 — pathology — Posted on 2022-09-26
880 Huntington's disease phenocopy syndromes revisited: a clinical comparison and next-generation sequencing exploration
Koriath, C. A. M.; Guntotoi, F.; Norseworthy, P.; Dolzhenko, E.; Eberle, M. A.; Hensman Moss, D. J.; Flower, M.; Hummerich, H.; Rosser, A. E.; Tabrizi, S. J.; Mead, S. H.; Wild, E.
10.1101/2022.09.23.509161 — genetics — Posted on 2022-09-26
881 Mating strategies in Caenorhabditis elegans populations are determined by male developmental history
Al-Saadi, R. S.; Luo, J.; Nichitean, A. M.; Wagner, N. R.; Portman, D. S.; Hall, S. E.
10.1101/2022.09.23.509199 — genetics — Posted on 2022-09-26
885 High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor control
Füchsl, F.; Untch, J.; Kavaka, V.; Jarosch, S.; Vogelsang, C.; de Andrade Krätzig, N.; Gosmann, D.; Rad, R.; Busch, D. H.; Beltran, E.; Bräunlein, E.; Krackhardt, A. M.
10.1101/2022.09.23.508529 — immunology — Posted on 2022-09-26
886 Combination Ad26.RSV.preF/RSV preF protein vaccine induces superior humoral, cellular, and protective immunity compared with individual vaccine components in preclinical models
Saeland, E.; van der Fits, L.; Bolder, R.; Heemskerk-van der Meer, M.; Drijver, J.; van Polanen, Y.; Vaneman, C.; Tettero, L.; Cox, F.; Serroyen, J.; Jorgensen, M. J.; Langedijk, J. P. M.; Schuitemaker, H.; Callendret, B.; Zahn, R. C.
10.1101/2022.09.23.509196 — immunology — Posted on 2022-09-26
887 Neurophysiological basis of hemodynamic responses in the developing human brain before the time of normal birth
Poppe, T.; Willers Moore, J.; Rupawala, M.; Price, A. N.; Godinez, F.; Whitehead, K.; Dall'Orso, S.; Edwards, D.; Fabrizi, L.; Arichi, T.
10.1101/2022.09.23.509234 — neuroscience — Posted on 2022-09-26
889 Mouse paralaminar amygdala excitatory neurons migrate and mature during adolescence
Alderman, P. J.; Saxon, D.; Torrijos-Saiz, L. I.; Sharief, M.; Biagiotti, S. W.; Page, C. E.; Melamed, A.; Kuo, C. T.; Garcia-Verdugo, J.-M.; Herranz-Perez, V.; Corbin, J. G.; Sorrells, S. F.
10.1101/2022.09.23.509244 — neuroscience — Posted on 2022-09-26
890 Water exchange rates measure active transport and homeostasis in neural tissue
Williamson, N. H.; Ravin, R.; Cai, T.; Falgairolle, M.; O'Donovan, M.; Basser, P.
10.1101/2022.09.23.483116 — neuroscience — Posted on 2022-09-26
893 Diel fluctuations in in-vivo SnRK1 activity in Arabidopsis rosettes during light-dark cycles
Avidan, O.; Alexandre Moraes, T.; Mengin, V.; Feil, R.; Rolland, F. A.; Stitt, M.; Lunn, J. E.
10.1101/2022.09.23.509272 — plant biology — Posted on 2022-09-26
902 The trans-zeatin-type side-chain modification of cytokinins controls rice growth
Kiba, T.; Mizutani, K.; Nakahara, A.; Takebayashi, Y.; Kojima, M.; Hobo, T.; Osakabe, Y.; Osakabe, K.; Sakakibara, H.
10.1101/2022.09.25.509405 — plant biology — Posted on 2022-09-26
903 The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae.
Li, H.; Wu, S.; Lin, R.; Xiao, Y.; Malaco Morotti, A. L.; Wang, Y.; Huang, T.; Zhao, Y.; Zhou, X.; Yang, J.; Zhao, Q.; Kanellis, A.; Martin, C.; Tatsis, E.
10.1101/2022.09.25.509435 — plant biology — Posted on 2022-09-26
905 Genome-wide association studies of seed metabolites identify loci controlling specialized metabolites in Arabidopsis thaliana
Naake, T.; Scossa, F.; Perez de Souza, L.; Borghi, M.; Brotman, Y.; Mori, T.; Nakabayashi, R.; Tohge, T.; Fernie, A. R.
10.1101/2022.09.23.509130 — plant biology — Posted on 2022-09-26
906 The giant diploid faba genome unlocks variation in a global protein crop
Jayakodi, M.; Golicz, A. A.; Kreplak, J.; Fechete, L. I.; Angra, D.; Bednar, P.; Bornhofen, E.; Zhang, H.; Boussageon, R.; Kaur, S.; Cheung, K.; Cizkova, J.; Gundlach, H.; Hallab, A.; Imbert, B.; Keeble-Gagnere, G.; Koblizkova, A.; Kobrlova, L.; Krejci, P.; Mouritzen, T. W.; Neumann, P.; Nadzieja, M.; Nielsen, L. K.; Novak, P.; Orabi, J.; Padmarasu, S.; Robertson-Shersby-Harvie, T.; Robledillo, L. A.; Schiemann, A.; Tanskanen, J.; Toronen, P.; Warsame, A. O.; Wittenberg, A. H. J.; Himmelbach, A.; Aubert, G.; Courty, P.-E.; Dolezel, J.; Holm, L. U.; Janss, L. L.; Khazaei, H.; Macas, J.; Mascher
10.1101/2022.09.23.509015 — plant biology — Posted on 2022-09-26
907 Mapping of the Classical Mutation rosette Highlights a Role for Calcium in Wound-induced Rooting
Modrego, A.; Pasternak, T.; Omary, M.; Albacete, A.; Cano, A.; Perez-Perez, J. M.; Efroni, I.
10.1101/2022.09.24.509321 — plant biology — Posted on 2022-09-26
909 Predicting treatment outcome using kinome activity profiling in HER2+ breast cancer biopsies
Debets, D. O.; de Graaf, E. L.; Liefaard, M. C.; Sonke, G. S.; Lips, E.; Ressa, A.; Altelaar, M.
10.1101/2022.09.23.508980 — cancer biology — Posted on 2022-09-26
910 Towards overtreatment-free immunotherapy: Using genomic scars to select treatment beneficiaries in lung cancer
Donker, H. C.; van Es, B.; Tamminga, M.; Lunter, G. A.; van Kempen, L. C. L. T.; Schuuring, E.; Hiltermann, T. J. N.; Groen, H. J. M.
10.1101/2022.09.23.509152 — cancer biology — Posted on 2022-09-26
916 Bio-Aurac an open-source browser plugin to better navigate literature content.
Evans, A. J.; Etherington, N. E. J.; Laing, M. P.; Rollings, B.; Sweeton, M. J.; Whitehorn, A. J.; Southan, C.; Holliday, G. L.; Jimenez, R. C.; Dunlop, I. W.
10.1101/2022.09.23.508995 — biochemistry — Posted on 2022-09-26
917 Odor-gated oviposition behavior in an ecological specialist
Alvarez-Ocana, R.; Shahandeh, M. P.; Ray, V.; Auer, T. O.; Gompel, N.; Benton, R.
10.1101/2022.09.23.509164 — animal behavior and cognition — Posted on 2022-09-26
919 Allele-specific expression reveals genetic drivers of tissue regeneration in mice
Talbott, H. E.; Mack, K. L.; Griffin, M.; Guardino, N. J.; Parker, J. B.; Spielman, A. F.; Davitt, M. F.; Mascharak, S.; Berger, M. J.; Wan, D. C.; Fraser, H. B.; Longaker, M. T.
10.1101/2022.09.23.509223 — genomics — Posted on 2022-09-26
922 Rapid expansion and visual specialization of learning and memory centers in Heliconiini butterflies
Couto, A.; Young, F. J.; Atzeni, D.; Marty, S.; Melo-Florez, L.; Hebberecht, L.; Monllor, M.; Neal, C.; Cicconardi, F.; McMillan, W. O.; Montgomery, S. H.
10.1101/2022.09.23.509163 — evolutionary biology — Posted on 2022-09-26
923 Genetic risk for Multiple Sclerosis originated in Pastoralist Steppe populations
Barrie, W.; Yang, Y.; Attfield, K. E.; Irving-Pease, E.; Scorrano, G.; Jensen, L. T.; Armen, A. P.; Dimopoulos, E. A.; Stern, A.; Refoyo-Martinez, A.; Ramsoe, A.; Gaunitz, C.; Demeter, F.; Jorkov, M. L. S.; Moller, S. B.; Springborg, B.; Klassen, L.; Hyldgard, I. M.; Wickmann, N.; Vinner, L.; Korneliussen, T. S.; Allentoft, M. E.; Sikora, M.; Kristiansen, K.; Rodriguez, S.; Nielsen, R.; Iversen, A. K. N.; Lawson, D. J.; Fugger, L.; Willerslev, E.
10.1101/2022.09.23.509097 — evolutionary biology — Posted on 2022-09-26
927 Immune-related molecular changes in the olfactory epithelium, structural alteration in the olfactory bulb, and psychosis
Yang, K.; Hasegawa, Y.; Hua, J.; Dower, M.; Etyemez, S.; Prasad, N.; Duvall, L. G.; Paez, A. K.; Smith, A.; Lane, A. P.; Ishizuka, K.; Kamath, V.; Kamiya, A.; Sawa, A.
10.1101/2022.09.23.509224 — molecular biology — Posted on 2022-09-26
928 Inhibition of Phosphodiesterase 12 results in Antiviral Activity against several RNA Viruses including SARS-CoV-2.
Karayiannis, P.; Thursz, M.; Sadiq, F.; Tree, J.; Beasley, D.; Dejnirattisai, W.; Mongkolsapaya, J.; Screaton, G.; Wand, M.; Elmore, M.; Miles, C.; Matthews, I.; Thomas, H.
10.1101/2022.09.23.509178 — microbiology — Posted on 2022-09-26
930 PKB/AKT attenuates Lewy Body-like pathology in primary neurons via Cathepsins B and D
Konovalova, J.; Er, S.; Barut, J.; Rafa-Zablocka, K.; Luk, K.; Figiel, M.; Airavaara, M.; Domanskyi, A.; Chmielarz, P.
10.1101/2022.09.23.508066 — neuroscience — Posted on 2022-09-26
931 AAV-delivered gene editing for latent genital or orofacial herpes simplex virus infection reduces ganglionic viral load and minimizes subsequent viral shedding in mice
Aubert, M.; Haick, A. K.; Strongin, D. E.; Klouser, L. M.; Loprieno, M. A.; Stensland, L.; Santo, T. K.; Huang, M.-l.; Hyrien, O.; Stone, D.; Jerome, K. R.
10.1101/2022.09.23.509057 — neuroscience — Posted on 2022-09-26
934 Characterization of sub-tropical maize (Zea Mays L.) inbred lines for the variation in kernel row numbers (KRN)
Mukri, G.; Gadag, R. N.; Bhat, J. S.; Nepolean, T.; Gupta, N. C.; Mittal, S.; ML, N.; Kumar, R.; Pal, D.
10.1101/2022.09.23.509129 — plant biology — Posted on 2022-09-26
935 CURLYLEAF is a key modulator of apoplast water status in Arabidopsis leaf
Xin, X.-F.; Wu, J.; Zhang, J.; Mei, X.; Wang, Y.; Ye, L.; Chen, T.; Liu, M.; Zhang, Y.
10.1101/2022.09.23.509124 — plant biology — Posted on 2022-09-26
936 A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0
Zivanov, J.; Oton, J.; Ke, Z.; von Kügelgen, A.; Pyle, E.; Qu, K.; Morado, D.; Castano-Diez, D.; Zanetti, G.; Bharat, T.; Briggs, J.; Scheres, S.
10.1101/2022.02.28.482229 — biophysics — Posted on 2022-09-26
940 Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
Nguyen, A.; Lugarini, F.; David, C.; Hosnani, P.; Knotkova, B.; Patel, A.; Parfentev, I.; Friedrich, A.; Urlaub, H.; Meinecke, M.; Stork, B.; Faesen, A.
10.1101/2022.09.21.508836 — biochemistry — Posted on 2022-09-26
944 Environmental regulation of gene expression mediated by Long non-coding RNAs
Kang, J.; Chung, A.; Suresh, S.; Bonzi, L. C.; Sourisse, J. M.; Ramirez-Calero, S.; Romeo, D.; Petit-Marty, N.; Pegueroles, C.; Schunter, C.
10.1101/2022.06.17.496488 — molecular biology — Posted on 2022-09-26
945 Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making
Musall, S.; Sun, X. R.; Mohan, H.; An, X.; Gluf, S.; Li, S.; Drewes, R.; Cravo, E.; Lenzi, I.; Yin, C.; Kampa, B. M.; Churchland, A. K.
10.1101/2021.09.27.461599 — neuroscience — Posted on 2022-09-26
948 Copy number variations shape the structural diversity of Arabidopsis metabolic gene clusters and are associated with the climatic gradient
Marszalek-Zenczak, M.; Satyr, A.; Wojciechowski, P.; Zenczak, M.; Sobieszczanska, P.; Brzezinski, K.; Iefimenko, T.; Figlerowicz, M.; Zmienko, A.
10.1101/2022.09.05.506152 — genomics — Posted on 2022-09-26
950 Divergent selection predating the Last Glacial Maximum mainly acted on macro-phenotypes in Norway spruce
Tiret, M.; Olsson, L.; Grahn, T.; Karlsson, B.; Milesi, P.; Lascoux, M.; Lundqvist, S.-O.; Garcia-Gil, M. R.
10.1101/2022.01.15.476468 — evolutionary biology — Posted on 2022-09-26
952 Bat pluripotent stem cells reveal unique entanglement between host and viruses
Dejosez, M.; Marin, A.; Hughes, G.; Morales, A.; Godoy Parejo, C.; Gray, J.; Qin, Y.; Singh, A.; Xu, H.; Juste, J.; Ibanez, C.; White, K. M.; Rosales, R.; Francoeur, N.; Sebra, R.; Alcock, D.; Pastusiak, A.; Frost, S.; Hiller, M.; Young, R.; Teeling, E.; Garcia-Sastre, A.; Zwaka, T. P.
10.1101/2022.09.23.509261 — developmental biology — Posted on 2022-09-26
953 INSULIN-LIKE GROWTH FACTOR I REDUCES CORONARY ATHEROSCLEROSIS IN PIGS WITH FAMILIAL HYPERCHOLESTEROLEMIA
Sukhanov, S.; Higashi, Y.; Yoshida, T.; Danchuk, S.; Alfortish, M.; Goodchild, T.; Scarborough, A.; Sharp, T.; Jenkins, J. S.; Garcia, D.; Ivey, J.; Tharp, D. L.; Schumacher, J.; Rozenbaum, Z.; Kolls, J. K.; Bowles, D.; Lefer, D.; Delafontaine, P.
10.1101/2022.09.23.509213 — cell biology — Posted on 2022-09-26
955 Investigating microglia-neuron crosstalk by characterizing microglial contamination in human and mouse Patch-seq datasets
Arbabi, K.; Jiang, Y.; Howard, D.; Nigam, A.; Inoue, W.; Gonzalez-Burgos, G.; Felsky, D.; Tripathy, S. J.
10.1101/2022.09.07.507009 — neuroscience — Posted on 2022-09-26
958 High-dimensional association detection in large scale genomic data
Koch, H.; Keller, C. A.; Xiang, G.; Giardine, B.; Zhang, F.; Wang, Y.; Hardison, R. C.; Li, Q.
10.1101/2020.11.18.388504 — bioinformatics — Posted on 2022-09-26
962 HNF1α transcriptional activation and repression maintain human islet α and β cell function
Qian, M. F.; Bevacqua, R. J.; Nguyen, V. M.; Liu, X.; Zhao, W.; Chang, C. A.; Gu, X.; Dai, X.-Q.; Macdonald, P. E.; Kim, S. K.
10.1101/2022.09.25.509394 — genetics — Posted on 2022-09-25
965 Top-down design of protein nanomaterials with reinforcement learning
Lutz, I. D.; Wang, S.; Norn, C.; Borst, A. J.; Zhao, Y. T.; Dosey, A.; Cao, L.; Li, Z.; Baek, M.; King, N. P.; Ruohola-Baker, H.; Baker, D.
10.1101/2022.09.25.509419 — synthetic biology — Posted on 2022-09-25
966 B lymphocytes in Treatment-Naive Pediatric Lupus Patients are Epigenetically Distinct from Healthy Children
Hui-Yuen, J.; Jiang, K.; Malkiel, S.; Eberhard, B. A.; Walters, H.; Diamond, B.; Jarvis, J. N.
10.1101/2022.09.23.509218 — genomics — Posted on 2022-09-25
969 SAGA histone acetyltransferase module facilitates chromatin accessibility to SMC5/6
Mahrik, L.; Stefanovie, B.; Maresova, A.; Princova, J.; Kolesar, P.; Lelkes, E.; Helmlinger, D.; Prevorovsky, M.; Palecek, J. J.
10.1101/2022.09.24.508842 — genetics — Posted on 2022-09-25
971 Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA
Isaac, R. S.; Tullius, T. W.; Hansen, K. G.; Dubocanin, D.; Couvillion, M.; Stergachis, A.; Churchman, L. S.
10.1101/2022.09.25.509398 — molecular biology — Posted on 2022-09-25
972 A novel, ssDNA Bidnavirus in the giant freshwater prawn Macrobrachium rosenbergii
Gangnonngiw, W.; Bunnontae, M.; Kayansamruaj, P.; Senapin, S.; Srisala, J.; Flegel, T. W.; Wongprasert, K.
10.1101/2022.09.25.509311 — microbiology — Posted on 2022-09-25
973 Digestive exophagy of Bacterial Biofilms by an Amoeba Predator is Mediated by Specific Biofilm Recognition
Zanditenas, E.; Trebicz-Geffen, M.; Dominguez-Garcia, L.; romero, d.; Kolodkin-Gal, I.; Ankri, S.
10.1101/2022.09.24.509356 — microbiology — Posted on 2022-09-25
974 A helminth mimic of TGF-β, TGM, enhances regenerative cutaneous wound healing and modulates immune cell recruitment and activation
Lothstein, K. E.; Chen, F.; Mishra, P.; Smyth, D. J.; Wu, W.; Lemenze, A.; Kumamoto, Y.; Maizels, R. M.; Gause, W. C.
10.1101/2022.09.24.509317 — immunology — Posted on 2022-09-25
975 Acquired secondary HER2 mutations enhance HER2/MAPK signaling and promote resistance to HER2 kinase inhibition in HER2-mutant breast cancer
Marin, A.; Mamun, A. A.; Akamatsu, H.; Ye, D.; Sudhan, d. R.; Brown, B. P.; Eli, L.; Marcelain, K.; Meiler, J.; Arteaga, C. L.; Hanker, A. B.
10.1101/2022.09.23.509246 — cancer biology — Posted on 2022-09-25
977 Benchmark data and software for assessing genome-wide CRISPR-Cas9 screening pipelines
Iannuzzi, R.; Manipur, I.; Pacini, C.; Behan, F. M.; Guarracino, M. R.; Garnett, M. J.; Savino, A.; Iorio, F.
10.1101/2022.09.23.509258 — bioinformatics — Posted on 2022-09-25
979 The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase
Bardwell, A. J.; Andrade-Ludena, M. D.; Yoneda, K. C.; Nguyen, O. T.; Fruman, D. A.; Bardwell, L.
10.1101/2022.09.24.509339 — biochemistry — Posted on 2022-09-25
980 Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein
Jelinska, C.; Kannan, S.; Winnerdy, F. R.; Frosi, Y.; Ramlan, S. R.; Lakshminarayanan, R.; Brown, C. J.; Phan, A.-T.; Rhodes, D.; Verma, C. S.
10.1101/2022.09.25.508451 — biochemistry — Posted on 2022-09-25
985 Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway
Harper, C. E.; Zhang, W.; Shin, J.-H.; van Wijngaarden, E.; Chou, E.; Lee, J.; Wang, Z.; Doerr, T.; Chen, P.; Hernandez, C. J.
10.1101/2022.09.25.509347 — microbiology — Posted on 2022-09-25
988 PICLN modulates alternative splicing and ensures adaptation to light and temperature changes in plants
Mateos, J. L.; Sanchez, S. E.; Legris, M.; Esteve-Bruna, D.; Torchio, J. C.; Petrillo, E.; Goretti, D.; Blanco-Tourinan, N.; Seymour, D. K.; Schmid, M.; Weigel, D.; Alabadi, D.; Yanovsky, M. J.
10.1101/2022.06.14.496170 — plant biology — Posted on 2022-09-25
993 Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
Nguyen, A.; Lugarini, F.; David, C.; Hosani, P.; Knotkova, B.; Patel, A.; Parfentev, I.; Friedrich, A.; Urlaub, H.; Meinecke, M.; Stork, B.; Faesen, A.
10.1101/2022.09.21.508836 — biochemistry — Posted on 2022-09-25
997 Decision heuristics in contexts exploiting intrinsic skill
Dundon, N. M.; Colas, J. T.; Garrett, N.; Babenko, V.; Rizor, E.; Yang, D.; MacNamara, M.; Petzold, L.; Grafton, S. T.
10.1101/2022.04.01.486746 — neuroscience — Posted on 2022-09-25
998 A Murine Model of Abductor Insufficiency Accelerates the Development of Hip Osteoarthritis
Geary, M. B.; Orner, C. A.; Shammas, H.; Reuter, J. M.; Loiselle, A. E.; Giordano, B. D.; Wu, C.-L.
10.1101/2022.05.22.492940 — pathology — Posted on 2022-09-25
999 ADRA2B and HTR1A: An updated study of the biogenic amine receptors reveals novel conserved motifs which play key role in Mental Disorders.
Papageorgiou, L.; Christou, E.; Louka, E.; Papakonstantinou, E.; Diakou, I.; Pierouli, K.; Dragoumani, K.; Bacopoulou, F.; Chrousos, G. P.; Eliopoulos, E.; Vlachakis, D.
10.1101/2022.09.16.508280 — bioinformatics — Posted on 2022-09-25
1000 Genetic, clinical underpinnings of subtle early brain change along Alzheimer's dimensions
Wen, J.; Yang, Z.; Nasrallah, I.; Cui, Y.; Erus, G.; Srinivasan, D.; Abdulkadir, A.; Mamourian, E.; Hwang, G.; Singh, A.; Bergman, M.; Bao, J.; Varol, E.; Zhou, Z.; Boquet-Pujadas, A.; Chen, J.; Toga, A. W.; Saykin, A. J.; Hohman, T.; Thompson, P.; Villeneuve, S.; Gollub, R.; Sotiras, A.; Wittfeld, K.; Grabe, H.; Tosun, D.; Bilgel, M.; An, Y.; Marcus, D.; LaMontagne, P. J.; Heckbert, S.; Austin, T.; Launer, L.; Espeland, M.; Masters, C.; Maruff, P.; Fripp, J.; Johnson, S. C.; Morris, J.; Albert, M.; Bryan, R. N.; Resnick, S. M.; Ferrucci, L.; Fan, Y.; Mohamad, H.; Wolk, D.; Shen, L.; Shou, H.;
10.1101/2022.09.16.508329 — bioengineering — Posted on 2022-09-25
1001 Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids
Costa, B.; Li Calzi, M.; Castellano, M.; Blanco, V.; Cuevasanta, E.; Litvan, I.; Ivanov, P.; Witwer, K.; Cayota, A.; Tosar, J. P.
10.1101/2022.08.31.506125 — molecular biology — Posted on 2022-09-25
1008 YAP/TAZ mediate TGFβ2-induced Schlemm's canal cell dysfunction
Li, H.; Singh, A.; Perkumas, K. M.; Stamer, W. D.; Ganapathy, P. S.; Herberg, S.
10.1101/2022.06.06.494681 — cell biology — Posted on 2022-09-25
1009 ErbB Signalling is a Potential Therapeutic Target for Vascular Lesions with Fibrous Component
Ilmonen, H.; Jauhiainen, S.; Vuola, P.; Rasinkangas, H.; Pulkkinen, H. H.; Keränen, S.; Kiema, M.; Liikkanen, J. J.; Laham-Karam, N.; Laidinen, S.; Aavik, E.; Lappalainen, K.; Lohi, J.; Aronniemi, J.; Örd, T.; Kaikkonen, M. U.; Salminen, P.; Tukiainen, E.; Ylä-Herttuala, S.; Laakkonen, J. P.
10.1101/2022.09.23.509204 — cell biology — Posted on 2022-09-25
1010 Microbiome and resistome dynamics along a sewage-effluent-reservoir continuum underline the role of natural attenuation in effluent receiving reservoirs
Cytryn, E.; Leao, I.; Khalifa, L.; Merlin, C.; Gallois, N.; Vaz-Moreira, I.; Klümper, U.; Youdkes, D.; Palmony, S.; Dagai, L.; Berendonk, T. U.; Manaia, C.
10.1101/2022.09.21.508967 — microbiology — Posted on 2022-09-25
1012 Programmed cell death-1 receptor mediated regulation of Tbet+ NK1.1- Innate Lymphoid Cells within the Tumor Microenvironment
Lim, M.; Lai, C.; Mallett, G.; McDonald, D.; Hulme, G.; Laba, S.; Shapanis, A.; Payne, M.; Patterson, W.; Alexander, M.; Coxhead, J.; Filby, A.; Plummer, R.; Lovat, P.; Sciume, G.; Healy, E.; Amarnath, S.
10.1101/2022.09.21.507469 — immunology — Posted on 2022-09-25
1014 Glucose intolerance in aging is mediated by the Gpcpd1-GPC metabolic axis
Cikes, D.; Leutner, M.; Cronin, S. J. - F.; Novatchkova, M.; Pfleger, L.; Klepochova, R.; Rullman, E.; Gustafsson, T.; Hagelkrueys, A.; Knauf, C.; Moro, C.; Krebs, M.; Kautzky-Willer, A.; Krssak, M.; Orthofer, M.; Penninger, J. M.; Lair, B.; Lac, M.; Bergoglio, C.; Tavernier, G.; Bourlier, V.; Durnberger, G.; Roitinger, E.
10.1101/2021.10.26.465828 — physiology — Posted on 2022-09-25
1018 Massive Horizontal Gene Transfer in Amphioxus Illuminates the Early Evolution of Deuterostomes
Xiong, Q.; Yang, K. Y.; Zeng, X.; Wang, M.; Ng, P. K.-S.; Zhou, J.-W.; Ng, J. K.-W.; Law, C. T.-Y.; Du, Q.; Xu, K.; Falkenberg, L. J.; Mao, B.; Chen, J.-Y.; Tsui, S. K.-W.
10.1101/2022.05.18.492404 — evolutionary biology — Posted on 2022-09-25
1019 Parallel evolution of amphioxus and vertebrate small-scale gene duplications
Braso-Vives, M.; Marletaz, F.; Echchiki, A.; Mantica, F.; Acemel, R. D.; Gomez-Skarmeta, J. L.; Hartasanchez, D. A.; Targa, L. L.; Pontarotti, P.; Tena, J. J.; Maeso, I.; Escriva, H.; Irimia, M.; Robinson-Rechavi, M.
10.1101/2022.01.18.476203 — evolutionary biology — Posted on 2022-09-25
1020 The non-random structure of multi-trophic ecological interactions maximizes species coexistence
Garcia-Callejas, D.; Godoy, O.; Buche, L.; Hurtado, M.; B. Lanuza, J.; Allen-Perkins, A.; Bartomeus, I.
10.1101/2021.11.29.470335 — ecology — Posted on 2022-09-25
1021 CD90 is not constitutively expressed in functional innate lymphoid cells
Schroeder, J.-H.; Beattie, G.; Lo, J. W.; Zabinski, T.; Jenner, R.; Powell, N.; Neves, J. F.; Lord, G. M.
10.1101/2021.12.11.472210 — immunology — Posted on 2022-09-25
1022 Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism
Bridi, M.; Luo, N.; Kim, G.; O'Ferrall, C.; Oatel, R.; Bertrand, S.; Kannan, S.; Kirkwood, A.
10.1101/2021.07.05.451213 — neuroscience — Posted on 2022-09-25
1023 Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials
Grasskamp, A. T.; Jusyte, M.; McCarthy, A. W.; Goetz, T. W. B.; Ditlevsen, S.; Walter, A. M.
10.1101/2020.08.28.271742 — neuroscience — Posted on 2022-09-25
1028 CRISPR-Cas Controls Cryptic Prophages
Song, S.; Semenova, E.; Severinov, K.; Garcia, L. F.; Benedik, M. J.; Maeda, T.; Wood, T. K.
10.1101/2021.07.28.454074 — molecular biology — Posted on 2022-09-25
1031 Ultraliser: a framework for creating multiscale, high-fidelity and geometrically realistic 3D models for in silico neuroscience
Abdellah, M.; Garcia Cantero, J. J.; Roman Guerrero, N.; Foni, A.; Coggan, J. S.; Cali, C.; Agus, M.; Zisis, E.; Keller, D.; Hadwiger, M.; Magistretti, P.; Markram, H.; Schürmann, F.
10.1101/2022.07.27.501675 — bioinformatics — Posted on 2022-09-25
1032 ICAT: A Novel Algorithm to Robustly Identify Cell States Following Perturbations in Single Cell Transcriptomes
Hawkins, D. Y.; Zuch, D. T.; Huth, J.; Rodriguez-Sastre, N. C.; McCutcheon, K. R.; Glick, A.; Lion, A. T.; Thomas, C. F.; Descoteaux, A.; Johnson, W. E.; Bradham, C.
10.1101/2022.05.26.493603 — bioinformatics — Posted on 2022-09-25
1033 HAYSTAC: A Bayesian framework for robust and rapid species identification in high-throughput sequencing data
Dimopoulos, E. A.; Carmagnini, A.; Velsko, I. M.; Warinner, C.; Larson, G.; Frantz, L. A. F.; Irving-Pease, E. K.
10.1101/2020.12.16.419085 — bioinformatics — Posted on 2022-09-25
1034 Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability
Haynes, L. M.; Huttinger, Z. M.; Yee, A.; Kretz, C. A.; Siemieniak, D. R.; Lawrence, D. A.; Ginsburg, D.
10.1101/2022.07.19.500671 — biochemistry — Posted on 2022-09-25
1038 Longitudinal single-cell chemical imaging of engineered strains reveals heterogeneity in fatty acid production
Tague, N.; Lin, H.; Lugagne, J.-B.; O'Connor, O. M.; Burman, D.; Wong, W.; Cheng, J.-X.; Dunlop, M.
10.1101/2021.07.26.453865 — synthetic biology — Posted on 2022-09-25
1039 KDM4A promotes NEPC progression through regulation of MYC expression
Mak, C. S. L.; Zhu, M.; Liang, X.; Wang, F.; Hoang, A. G.; Song, X.; Shepherd, P.; Liang, D.; Park, J.; Zhang, M.; Metzger, E.; Schule, R.; Jain, A. K.; Foster, B. A.; Lee, M. G.; Corn, P.; Logothetis, C. J.; Aparicio, A.; Navone, N.; Troncoso, P.; Zhang, J.; Lin, S.-H.; Wang, G.
10.1101/2022.05.14.491739 — cancer biology — Posted on 2022-09-25
1045 Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells
He, J.; Abikoye, A. M.; McLaughlin, B. P.; Middleton, R. S.; Sheldon, R.; Jones, R. G.; Schafer, Z. T.
10.1101/2022.09.23.509253 — cell biology — Posted on 2022-09-25
1047 Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition
Arabanian, L. S.; Adamsson, J.; Unger, A.; Di Lucrezia, R.; Bergbrede, T.; Ashouri, A.; Larsson, E.; Nussbaumer, P.; Klebl, B. M.; Palmqvist, L.; Gustafsson, C. M.
10.1101/2022.09.23.509145 — cancer biology — Posted on 2022-09-25
1050 Enhancing Sox/Oct cooperativity induces higher-grade developmental reset
MacCarthy, C. M.; Malik, V.; Wu, G.; Velychko, T.; Keshet, G.; Jauch, R.; Cojocaru, V.; Scholer, H.; Velychko, S.
10.1101/2022.09.23.509242 — developmental biology — Posted on 2022-09-25
1051 Ribosomal RNA 2'-O-methylation dynamics impact cell fate decisions
Hafner, S. J.; Jansson, M. D.; Altinel, K.; Kraushar, M.; Andersen, K. L.; Caldwell Abay-Norgaard, Z.; Fontenas, M.; Sorensen, D.; Gay, D. M.; Arendrup, F. S.; Tehler, D.; Krogh, N.; Nielsen, H.; Kirkeby, A.; Lund, A. H.
10.1101/2022.09.24.509301 — developmental biology — Posted on 2022-09-25
1052 Reevaluation of Piezo1 as a gut RNA sensor
Nickolls, A. R.; O'Brien, G. S.; Shnayder, S.; Zhang, Y.; Nagel, M.; Patapoutian, A.; Chesler, A. T.
10.1101/2022.09.23.509216 — cell biology — Posted on 2022-09-24
1053 A spatial atlas of Wnt and Frizzled receptor expression in adult mouse liver
Gayden, J.; Hu, S.; Joseph, P. N.; Delgado, E.; Liu, S.; Bell, A.; Puig, S.; Monga, S. P.; Freyberg, Z.
10.1101/2022.09.23.509269 — cell biology — Posted on 2022-09-24
1058 Olfactory neuronal cells: biopsied surrogates for neurons in the brain
Yang, K.; Ishizuka, K.; Narita, Z.; Lema, Y. Y.; Zhang, S.; Duan, J.; Younes, L.; Geman, D.; Lane, A. P.; Sawa, A.
10.1101/2022.09.23.509290 — molecular biology — Posted on 2022-09-24
1059 Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile
Olaitan, A. O.; Dureja, C.; Youngblom, M.; Topf, M. A.; Shen, W.-J.; Gonzales-Luna, A. J.; Deshpande, A.; Hevener, K. E.; Freeman, J.; Wilcox, M. H.; Palmer, K. L.; Garey, K. W.; Pepperell, C. S.; Hurdle, J. G.
10.1101/2022.09.23.509282 — microbiology — Posted on 2022-09-24
1060 Identification of 2-amino benzothiazoles with bactericidal activity against Mycobacterium tuberculosis
Bonnett, S. A.; Jee, J.-A.; Chettiar, S.; Ovechkina, Y.; Korkegian, A.; Greve, E.; Odingo, J.; Parish, T.
10.1101/2022.09.23.509298 — microbiology — Posted on 2022-09-24
1062 Tunable dynamics in a multi-straintranscriptional pulse generator
Zong, D. M.; Sadeghpour, M.; Molinari, S.; Alnahhas, R. N.; Hirning, A. J.; Giannitsis, C.; Ott, W.; Josic, K.; Bennett, M. R.
10.1101/2022.09.23.509237 — synthetic biology — Posted on 2022-09-24
1064 Metallothionein-3 attenuates the effect of Cu2+ ions on actin filaments
Lakha, R.; Hachicho, C.; Mehlenbacher, M. R.; Wilcox, D. E.; Austin, R. N.; Vizcarra, C. L.
10.1101/2022.09.23.509211 — biochemistry — Posted on 2022-09-24
1066 Genome-scale mapping of DNA damage suppressors identifies GNB1L as essential for ATM and ATR biogenesis
Zhao, Y.; Tabet, D.; Rubio Contreras, D.; Kousholt, A. N.; Weile, J.; Melo, H.; Hoeg, L.; Cote, A. G.; Lin, Z.-Y.; Setiaputra, D.; Jonkers, J.; Gingras, A.-C.; Gomez Herreros, F.; Roth, F. P.; Durocher, D.
10.1101/2022.09.23.508845 — molecular biology — Posted on 2022-09-24
1067 Novel Biosensor Identifies Ruxolitinib as a Potent and Cardioprotective CaMKII Inhibitor
Reyes Gaido, O. E.; Granger, J. M.; Nkashama, L. J.; Lin, B. L.; Long, A.; Mesubi, O. O.; Schole, K. L.; Terrillion, C. E.; Liu, J. O.; Luczak, E. D.; Anderson, M. E.
10.1101/2022.09.24.509320 — molecular biology — Posted on 2022-09-24
1073 Microprobe-XRF assessment of nutrient distribution in soybean, cowpea, and kidney bean seeds: a Fabaceae family case study
Montanha, G. S.; Zachi Romeu, S. L.; Marques, J. P. R.; Rohr, L. A.; de Almeida, E.; dos Reis, A. R.; Linhares, F. S.; Sabatini, S.; Pereira de Carvalho, H. W.
10.1101/2022.09.23.509231 — biochemistry — Posted on 2022-09-24
1076 Estradiol (E2) concentration shapes the chromatin binding landscape of the estrogen receptor
Han, A. L.; Vinod Paul, K.; Rao, S.; Brechbuhl, H. M.; Sartorius, C. A.; Ramachandran, S.; Kabos, P.
10.1101/2022.09.23.509212 — molecular biology — Posted on 2022-09-24
1078 Global mosquito virome profiling and mosquito spatial diffusion pathways revealed by marker-viruses
Zhao, L.; Yu, P.; Shi, C.; Jia, L.; Evans, A.; Wang, X.; Wu, Q.; Xiong, G.; Ming, Z.; Salazar, F.; Agwanda, B.; Bente, D.; Wang, F.; Liu, D.; Yuan, Z.; Xia, H.
10.1101/2022.09.24.509300 — microbiology — Posted on 2022-09-24
1079 Compounds derived from N,N-dimethyldithiocarbamate are effective copper-dependent antimicrobials against Streptococcus pneumoniae
Johnson, M. D. L.; Menghani, S. V.; Sanchez-Rosario, Y.; Pok, C.; Liu, R.; Gao, F.; O'Brien, H. L.; Neubert, M.; Ochoa, K.; Hellinger, R. D.; Wang, W.
10.1101/2022.09.23.509297 — microbiology — Posted on 2022-09-24
1080 Multisensory inputs control the regulation of time investment for mating by sexual experience in male Drosophila melanogaster
Kim, W. J.; Lee, S. G.; Kang, C.; Saad, B.; Nguyen, K.-N. H.; Guerra-Phalen, A.; Bui, D.; Abbas, A.-H.; Trinh, B.; Malik, A.; Zeghal, M.; Auge, A.-C.; Islam, M. E.; Wong, K.; Stern, T.; Lebedev, E.; Sun, D.; Miao, H.; Wu, Z.; Sherratt, T. N.
10.1101/2022.09.23.509131 — neuroscience — Posted on 2022-09-24
1081 Cell-type specific deletions of Neuroligin 2 reveal a vital role of synaptic excitation-inhibition balance
Longley, C. M.; Xu, X.; Messier, J. E.; Cai, Z.-L.; Park, J. W.; Chen, H.; Reznik, D. L.; Jadi, M. P.; Xue, M.
10.1101/2022.09.23.509267 — neuroscience — Posted on 2022-09-24
1082 Release of the pre-assembled naRNA-LL37 composite DAMP re-defines neutrophil extracellular traps (NETs) as intentional DAMP webs
Bork, F.; Greve, C. L.; Youn, C.; Chen, S.; Wang, Y.; Nasri, M.; Focken, J.; Scheurer, J.; Engels, P.; Dubbelaar, M.; Hipp, K.; Schittek, B.; Bugl, S.; Loeffler, M. W.; Skokowa, J.; Archer, N. K.; Weber, A. N.
10.1101/2022.07.26.499571 — immunology — Posted on 2022-09-24
1089 scPerturb: Information Resource for Harmonized Single-Cell Perturbation Data
Peidli, S.; Green, T. D.; Shen, C.; Gross, T.; Min, J.; Garda, S.; Taylor-King, J.; Marks, D.; Luna, A.; Bluthgen, N.; Sander, C.
10.1101/2022.08.20.504663 — systems biology — Posted on 2022-09-24
1090 The establishment of Populus x Laccaria bicolor ectomycorrhiza requires the inactivation of MYC2 coordinated defense response with a key role for root terpene synthases
Marques-Galvez, J. E.; Basso, V.; Kohler, A.; Barry, K.; Keymanesh, K.; Johnson, J.; Singan, V.; Grigoriev, I. V.; Vilgalys, R.; Martin, F.; Veneault-Fourrey, C.
10.1101/2022.09.06.505662 — plant biology — Posted on 2022-09-24
1091 Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules in Two Rodent Models of Pulmonary Arterial Hypertension
Kazmirczak, F.; Hartweck, L.; Vogel, N. T.; Mendelson, J. B.; Park, J.; Raveendran, R. M.; O-Uchi, J.; Jhun, B. S.; Prisco, S.; Prins, K.
10.1101/2022.03.07.483333 — biochemistry — Posted on 2022-09-24
1093 Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice
Institoris, A.; Vandal, M.; Peringod, G.; Catalano, C.; Tran, C. H.; Yu, X.; Visser, F.; Breiteneder, C.; Molina, L.; Khakh, B. S.; Nguyen, M. D.; Thompson, R. J.; Gordon, G. R.
10.1101/2020.12.16.422785 — neuroscience — Posted on 2022-09-24
1095 RICTOR Drives ZFX-mediated Ganglioside Biosynthesis to Promote Breast Cancer Progression.
Rajput, K.; Ansari, M. N.; Jha, S. K.; Medatwal, N.; Sharma, P.; Datta, S.; Kar, A.; Pani, T.; Cholke, K.; Rana, K.; Khan, A.; Mukherjee, G.; Deo, S.; Prabhu, J. S.; Mukhopadhyay, A.; Bajaj, A.; Dasgupta, U.
10.1101/2022.01.10.475595 — cancer biology — Posted on 2022-09-24
1096 Alternative proteoforms and proteoform-dependent assemblies in humans and plants
McWhite, C. D.; Sae-Lee, W.; Yuan, Y.; Mallam, A. L.; Gort-Freitas, N. A.; Ramundo, S.; Onishi, M.; Marcotte, E. M.
10.1101/2022.09.21.508930 — systems biology — Posted on 2022-09-24
1097 Multimodal system for recording individual-level behaviors in songbird groups
Rüttimann, L.; Rychen, J.; Tomka, T.; Hörster, H.; Rocha, M. D.; Hahnloser, R. H.
10.1101/2022.09.23.509166 — animal behavior and cognition — Posted on 2022-09-23
1100 Conformational dynamics and target-dependent myristoyl switch of calcineurin B homologous protein 3
Becker, F.; Fuchs, S.; Refisch, L.; Drepper, F.; Bildl, W.; Schulte, U.; Liang, S.; Heinicke, J. I.; Hansen, S. C.; Kreutz, C.; Warscheid, B.; Fakler, B.; Mymrikov, E. V.; Hunte, C.
10.1101/2022.09.23.509142 — biochemistry — Posted on 2022-09-23
1103 A rapid protocol for ribosome profiling of low input samples
Meindl, A.; Romberger, M.; Lehmann, G.; Eichner, N.; Kleemann, L.; Wu, J.; Danner, J.; Boesl, M.; Mesitov, M.; Meister, G.; Koenig, J.; Leidel, S.; Medenbach, J.
10.1101/2022.09.23.509038 — systems biology — Posted on 2022-09-23
1105 N-linked glycosylation increases horse radish peroxidase rigidity leading to enhanced activity and stability.
Ramakrishnan, K.; Johnson, R.; Winter, S.; Worthy, H.; Thomas, C.; Humer, D.; Spadiut, O.; Hindson, S.; Wells, S. A.; Barratt, A.; Menzies, G.; Pudney, C. R.; Jones, D.
10.1101/2022.09.23.509167 — biochemistry — Posted on 2022-09-23
1108 Resolving chaperone-assisted protein folding on the ribosome at the peptide level
Wales, T. E.; Pajak, A.; Roeselova, A.; Shivakumaraswamy, S.; Howell, S.; Hartl, F.-U.; Engen, J. R.; Balchin, D.
10.1101/2022.09.23.509153 — biochemistry — Posted on 2022-09-23
1111 Taurine as a key intermediate for host-symbiont interaction in the tropical sponge Ianthella basta
Moeller, F. U.; Herbold, C. W.; Schintlmeister, A.; Mooshammer, M.; Motti, C.; Behnam, F.; Watzka, M.; Schweder, T.; Albertsen, M.; Richter, A.; Webster, N. S.; Wagner, M.
10.1101/2022.09.23.509140 — microbiology — Posted on 2022-09-23
1112 A glimpse of the paleome in endolithic microbial communities
Wegner, C.-E.; Stahl, R.; Velsko, I. M.; Huebner, A.; Fagernaes, Z.; Warinner, C.; Lehmann, R.; Ritschel, T.; Totsche, K. U.; Kuesel, K.
10.1101/2022.09.23.509128 — microbiology — Posted on 2022-09-23
1113 Interleukin-17 drives sex-dependent weight loss and changes in feeding behaviour during Trypanosoma brucei infection
Sinton, M. C.; Girard, A.; Ogunsola, J.; Chandrasegaran, P.; Capewell, P.; Perona-Wright, G.; Ngoyi, D.; Kuispond, N.; BUCHETON, B.; Camara, M.; Kajimura, S.; Benezech, C.; MacLeod, A.; Quintana Alcala, J. F.
10.1101/2022.09.23.509158 — immunology — Posted on 2022-09-23
1115 DHHC3 mediated Cadm4 palmitoylation regulates myelination in CNS
Chang, Y.; Zhu, J.; Nie, C.; Lu, Y.; Ren, F.; Cao, X.; Li, J.; Wang, C.; Yang, C.; Li, T.; Liang, Y.; Qi, S.; Kang, X.; Kong, E.
10.1101/2022.09.23.509146 — neuroscience — Posted on 2022-09-23
1118 A Haptoglobin (HP) Structural Variant Alters the Effect of APOE Alleles on Alzheimer's Disease
Bai, H.; Naj, A. C.; Benchek, P.; Dumitrescu, L.; Hohman, T.; Hamilton-Nelson, K.; Kallianpur, A. R.; Griswold, A. J.; Vardarajan, B.; Martin, E. R.; Beecham, G.; Below, J. E.; Schellenberg, G. D.; Mayeux, R.; Farrer, L.; Pericak-Vance, M. A.; Haines, J. L.; Bush, W. S.
10.1101/2022.09.22.508749 — genetics — Posted on 2022-09-23
1124 Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin
Doran, M. H.; Rynkiewicz, M. J.; Rasicci, D.; Bodt, S. M. L.; Barry, M. E.; Bullitt, E.; Yengo, C. M.; Moore, J. R.; Lehman, W.
10.1101/2022.09.23.509077 — biophysics — Posted on 2022-09-23
1125 DPAM: A Domain Parser for AlphaFold Models
Zhang, J.; Schaeffer, R. D.; Durham, J.; Cong, Q.; Grishin, N. V.
10.1101/2022.09.22.509116 — bioinformatics — Posted on 2022-09-23
1128 Functional interplay between Mediator and RSC chromatin remodeling complex controls nucleosome-depleted region maintenance at promoters
Andre, K. M.; Aiach, N. G.; Martinez-Fernandez, V.; Zeitler, L.; Goldar, A.; Werner, M.; Wilkes, C. D.; Soutourina, J.
10.1101/2022.09.22.509083 — genomics — Posted on 2022-09-23
1131 Grazers affect the composition of dissolved storage glycans and thereby bacterioplankton composition during a biphasic North Sea spring algae bloom
Sidhu, C.; Kirstein, I. V.; Meunier, C. L.; Rick, J.; Wiltshire, K. H.; Steinke, N.; Vidal-Melgosa, S.; Hehemann, J.-H.; Huettel, B.; Schweder, T.; Fuchs, B. M.; Amann, R. I.; Teeling, H.
10.1101/2022.09.22.509014 — ecology — Posted on 2022-09-23
1132 Neotropical birds and mammals show divergent behaviour responses to human pressure
Negret, P. J.; Luskin, M. S.; Diaz, A.; Romero, L. H.; Gomez-Valencia, B.; Restrepo, A.; Zahringer, J.; Ochoa-Quintero, J. M.; Mendes, C.
10.1101/2022.09.22.509119 — ecology — Posted on 2022-09-23
1134 Intestinal helminth infection impairs oral and parenteral vaccine efficacy
Hardy, L. C.; Kapita, C. M.; Campbell, E.; Hall, J. A.; Urban, J. F.; Belkaid, Y.; Nagler, C. R.; Iweala, O. I.
10.1101/2022.09.22.508369 — immunology — Posted on 2022-09-23
1135 Cytosolic condensates enriched in polyserine repeats are preferred sites of tau fiber propagation
Lester, E.; VanAlstyne, M.; McCann, K. L.; Reddy, S.; Cheng, L.; Kuo, J.; Pratt, J.; Parker, R.
10.1101/2022.09.22.509111 — neuroscience — Posted on 2022-09-23
1136 A natural language fMRI dataset for voxelwise encoding models
LeBel, A.; Wagner, L.; Jain, S.; Adhikari-Desai, A.; Gupta, B.; Morgenthal, A.; Tang, J.; Xu, L.; Huth, A. G.
10.1101/2022.09.22.509104 — neuroscience — Posted on 2022-09-23
1137 A role for myeloid miR-155 in regulating hypoxia induced seizures in neonatal C57BL/J6 mice
Dahiya, D.; Smith, J.; Strickland, T.; Morris, D.; Reschke, C.; Engel, T.; Henshell, D.; McCoy, C. E.; Dowling, J. K.
10.1101/2022.09.22.508924 — neuroscience — Posted on 2022-09-23
1140 Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility
Sayaman, R. W.; Miyano, M.; Senapati, P.; Zirbes, A.; Shalabi, S.; Todhunter, M. E.; Seewaldt, V.; Neuhausen, S. L.; Stampfer, M. R.; Schones, D. E.; LaBarge, M. A.
10.1101/2022.09.22.509091 — cancer biology — Posted on 2022-09-23
1142 Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming
Maduka, C. V.; Alhaj, M.; Ural, E.; Habeeb, M. O.; Kuhnert, M. M.; Smith, K.; Makela, A. V.; Pope, H.; Chen, S.; Hix, J. M.; Mallet, C. L.; Chung, S.-J.; Hakun, M.; Tundo, A.; Zinn, K. R.; Hankenson, K. D.; Goodman, S. B.; Narayan, R.; Contag, C. H.
10.1101/2022.09.22.509105 — bioengineering — Posted on 2022-09-23
1144 Gene expression and protein synthesis remodeling in response to iron deficiency in yeast
Barlit, H.; Romero, A. M.; Gulhan, A.; Patnaik, P. K.; Tyshkovskiy, A.; Martinez-Pastor, M. T.; Gladyshev, V. N.; Puig, S.; Labunskyy, V.
10.1101/2022.09.22.509115 — genetics — Posted on 2022-09-23
1146 Diversification is correlated with temperature in white and sulfur butterflies
Carvalho, A. P. S.; Owens, H. L.; St Laurent, R. A.; Earl, C.; Dexter, K. M.; Messcher, R. L.; Willmott, K. R.; Aduse-Poku, K.; Collins, S. C.; Homziak, N. T.; Hoshizaki, S.; Hsu, Y.-F.; Kizhakke, A. G.; Kunte, K.; Martins, D. J.; Mega, N. O.; Morinaka, S.; Peggie, D.; Romanowski, H. P.; Safian, S.; Vila, R.; Wang, H.; Braby, M. F.; Espeland, M.; Breinholt, J. W.; Pierce, N. E.; Kawahara, A. Y.; Lohman, D. J.
10.1101/2022.09.22.509088 — evolutionary biology — Posted on 2022-09-23
1152 Drug repurposing for Cystic Fibrosis: identification of drugs that induce CFTR-independent fluid secretion in nasal organoids
Rodenburg, L. W.; Delpiano, L.; Railean, V.; Centeio, R.; Pinto, M. C.; Smits, S. M. A.; van der Windt, I. S.; van Hugten, C. F. J.; van Beuningen, S. F. B.; Rodenburg, R. N. P.; van der Ent, C. K.; Amaral, M. D.; Kunzelmann, K.; Gray, M. A.; Beekman, J. M.; Amatngalim, G. D.
10.1101/2022.09.23.509034 — cell biology — Posted on 2022-09-23
1153 An optimized workflow to generate and characterize iPSC-derived motor neuron (MN) spheroids
Castellanos-Montiel, M. J.; Chaineau, M.; Franco-Flores, A. K.; Haghi, G.; Carrillo-Valenzuela, D.; Reintsch, W. E.; Chen, C. X.-Q.; Durcan, T. M.
10.1101/2022.09.22.509079 — neuroscience — Posted on 2022-09-23
1154 Neuronal pentraxin Nptx2 regulates complement activity in the brain
Zhou, J.; Wade, S. D.; Graykowski, D.; Xiao, M.-F.; Zhao, B.; Giannini, L. A.; Hanson, J. E.; van Swieten, J. C.; Sheng, M.; Worley, P. F.; Dejanovic, B.
10.1101/2022.09.22.509106 — neuroscience — Posted on 2022-09-23
1155 IRF7 impacts on prostate cancer cell survival in response to radiation
Pickard, A.; Amoroso, F.; McCulloch, K.; Erickson, A.; Sachdeva, A.; Steele, R.; Mukherjee, D.; Dellett, M.; McComb, J.; McCaffrey, L.; Hart, C.; Brown, M.; McDade, S. S.; Waugh, D.; Clarke, N.; Butterworth, K.; Illidge, T.; Mirtti, T.; Overton, I. M.; Mills, I.
10.1101/2022.09.23.509205 — cancer biology — Posted on 2022-09-23
1156 Statistical learning quantifies transposable element-mediated cis-regulation
Pulver, C.; Grun, D.; Duc, J.; Sheppard, S.; Planet, E.; De Fondeville, R.; Pontis, J.; Trono, D.
10.1101/2022.09.23.509180 — genomics — Posted on 2022-09-23
1157 Systematic analysis of transcriptional and epigenetic effects of genetic variation in Kupffer cells enables discrimination of cell intrinsic and environment-dependent mechanisms
Bennett, H.; Troutman, T. D.; Zhou, E.; Spann, N. J.; Link, V. M.; Seidman, J. S.; Nickl, C. K.; Abe, Y.; Sakai, M.; Pasillas, M. P.; Marlman, J. M.; Guzman, C.; Hosseini, M.; Schnabl, B.; Glass, C. K.
10.1101/2022.09.22.509046 — genomics — Posted on 2022-09-23
1158 Zooanthroponotic transmission of SARS-CoV-2 and host-specific viral mutations revealed by genome-wide phylogenetic analysis
Naderi, S.; Chen, P. E.; Murall, C. L.; Poujol, R.; Kraemer, S. A.; Pickering, B. S.; Sagan, S. M.; Shapiro, B. J.
10.1101/2022.06.02.494559 — genomics — Posted on 2022-09-23
1164 Imbalanced Unfolded Protein Response Signaling Contributes to 1-Deoxysphingolipid Retinal Toxicity
Rosarda, J. D.; Giles, S.; Harkins-Perry, S.; Mills, E. A.; Friedlander, M.; Wiseman, L.; Eade, K. T.
10.1101/2022.09.22.509071 — cell biology — Posted on 2022-09-23
1165 Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms
Nagasaka, K.; Davidson, I. F.; Stocsits, R.; Tang, W.; Wutz, G.; Batty, P.; Panarotto, M.; Litos, G.; Schleiffer, A.; Gerlich, D. W.; Peters, J. M.
10.1101/2022.09.23.509019 — cell biology — Posted on 2022-09-23
1166 CLASP2 facilitates dynamic actin filament organization along the microtubule lattice
Rodgers, N. C.; Lawrence, E. J.; Sawant, A. V.; Efimova, N.; Gonzalez-Vasquez, G.; Hickman, T. T.; Kaverina, I.; Zanic, M.
10.1101/2022.09.22.509100 — cell biology — Posted on 2022-09-23
1169 Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism
Mhlekude, B.; Postmus, D.; Weiner, J.; Stenzel, S.; Zapatero-Belinchon, F. J.; Olmer, R.; Jansen, J.; Richter, A.; Heinze, J.; Heinemann, N.; Muhlemann, B.; Schroeder, S.; Jones, T. C.; Muller, M. A.; Drosten, C.; Pich, A.; Thiel, V.; Martin, U.; Niemeyer, D.; Gerold, G.; Beule, D.; Goffinet, C.
10.1101/2022.09.22.508962 — microbiology — Posted on 2022-09-23
1170 Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection
Zhou, T.; Gilliam, N. J.; Li, S.; Spaudau, S.; Osborn, R.; Anderson, C. S.; Mariani, T. J.; Thakar, J.; Dewhurst, S.; Mathews, D. H.; Huang, L.; Sun, Y.
10.1101/2022.09.22.509123 — microbiology — Posted on 2022-09-23
1173 HeberFERON distinctively targets Cell Cycle in the glioblastoma-derived cell line U-87MG.
Miranda, J.; Vazquez-Blomquist, D.; Bringas, R.; Fernandez-de-Cossio, J.; Palenzuela, D.; Novoa, L. I.; Iraldo, B.-R. J.
10.1101/2022.09.22.508971 — cancer biology — Posted on 2022-09-23
1174 USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development
Novellasdemunt, L.; Kucharska, A.; Baulies, A.; Vlachogiannis, G.; Repana, D.; Rowan, A.; Suarez-Bonnet, A.; Ciccarelli, F.; Valeri, N.; Li, V. S. W.
10.1101/2022.09.22.508986 — cancer biology — Posted on 2022-09-23
1175 Transcriptionally defined morphological subtypes of pancreatic ductal adenocarcinoma
Krieger, T. G.; Sudy, A.; Schicktanz, F.; Tosti, L.; Liebig, J.; Konukiewitz, B.; Rouault, M.; Niesnerova, A.; Qian, X.; Weichert, W.; Eils, R.; Steiger, K.; Conrad, C.
10.1101/2022.09.23.509133 — cancer biology — Posted on 2022-09-23
1179 Single molecule long-read real-time amplicon-based sequencing of CYP2D6: a proof-of-concept with hybrid haplotypes
Dong, R.; Thamilselvan, M.; Hu, X.; Carvalho Henriques, B.; Wang, Y.; Wallace, K.; Sivapalan, S.; Buchner, A.; Yavorskyy, V.; Martens, K.; Maier, W.; Henigsberg, N.; Hauser, J.; Cattaneo, A.; Mors, O.; Rietschel, M.; Pfeffer, G.; Aitchison, K. J.
10.1101/2022.08.17.503990 — genomics — Posted on 2022-09-23
1180 Selective enrichment of plasma cell-free messenger RNA in cancer-associated extracellular vesicles
Kim, H. J.; Rames, M. J.; Roskams-Hieter, B.; Briand, J.; Doe, A.; Estabrook, J.; Wagner, J. T.; Demir, E.; Mills, G.; Ngo, T. M.
10.1101/2022.09.22.509102 — genomics — Posted on 2022-09-23
1181 The Selection Landscape and Genetic Legacy of Ancient Eurasians
Irving-Pease, E. K.; Refoyo-Martinez, A.; Ingason, A.; Pearson, A.; Fischer, A.; Barrie, W.; Sjögren, K.-G.; Halgren, A. S.; Macleod, R.; Demeter, F.; Henriksen, R. A.; Vimala, T.; McColl, H.; Vaughn, A.; Speidel, L.; Stern, A. J.; Scorrano, G.; Ramsoe, A.; Schork, A. J.; Rosengren, A.; Zhao, L.; Kristiansen, K.; Sudmant, P. H.; Lawson, D. J.; Durbin, R.; Korneliussen, T.; Werge, T.; Allentoft, M. E.; Sikora, M.; Nielsen, R.; Racimo, F.; Willerslev, E.
10.1101/2022.09.22.509027 — evolutionary biology — Posted on 2022-09-23
1182 Multi-site phosphorylation of the TOPBP1 ATR Activation Domain propels ATR signaling during the response to DNA breaks
Senebandith, H.; Ruis, K.; Montales, K.; Huynh, O.; Jami-Alahmadi, Y.; Wohlschlegel, J.; Michael, W. M.
10.1101/2022.09.19.508511 — cell biology — Posted on 2022-09-23
1184 A Drosophila model of diabetic neuropathy reveals a crucial role of proteasome activity in the glia
Suzuki, M.; Kuromi, H.; Shindo, M.; Sakata, N.; Niimi, N.; Fukui, K.; Saitoe, M.; Sango, K.
10.1101/2022.09.22.509008 — neuroscience — Posted on 2022-09-23
1185 Yeast NDI1 expression prevents the unfolded protein response and reconfigures metabolism to restore neuronal function in mitochondrial complex I deficiency
Granat, L.; Ranson, D.; Hamer, E.; Chakrabarty, R. P.; Mattedi, F.; Fort-Aznar, L.; Hirth, F.; Sweeney, S.; Vagnoni, A.; Chandel, N. S.; Bateman, J. M.
10.1101/2022.09.22.509020 — neuroscience — Posted on 2022-09-23
1186 Integrated cardio-behavioural defensive states
Signoret-Genest, J.; Schukraft, N.; Reis, S. L.; Segebarth, D.; Tovote, P.
10.1101/2022.09.22.509009 — neuroscience — Posted on 2022-09-23
1189 A SHR-IDD-PIN regulatory network mediates minor vein differentiation in rice
Liu, Q.; Teng, S.; Deng, C.; Wu, S.; Li, H.; Wang, Y.; Wu, J.; Cui, X.; Zhang, Z.; Quick, W. P.; Brutnell, T. P.; Sun, X.; Lu, T.
10.1101/2022.09.22.509058 — plant biology — Posted on 2022-09-23
1191 A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
Jones, M. J. K.; Rai, S. K.; Pfuderer, P. L.; Bonfim-Melo, A.; Pagan, J. K.; Clarke, P. R.; McClelland, S. E.; Boemo, M. A.
10.1101/2022.09.22.509021 — cancer biology — Posted on 2022-09-23
1192 Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables
Brummer, A. B.; Xella, A.; Woodall, R.; Adhikarla, V.; Cho, H.; Gutova, M. B.; Brown, C. E.; Rockne, R. C.
10.1101/2022.09.22.508748 — cancer biology — Posted on 2022-09-23
1193 Developmental reprogramming mediates aberrant cell state plasticity in colorectal cancer initiation
Bala, P.; Rennhack, J. P.; Morris, C. X.; Aitymbayev, D.; Moyer, S. M.; Duronio, G. N.; Doan, P.; Liang, X.; Hornick, J. L.; Yurgelun, M. B.; Hahn, W.; Sethi, N. S.
10.1101/2022.09.22.509032 — cancer biology — Posted on 2022-09-23
1198 When Mechanical Stress Matters: Generation of Polyploid Giant Cancer Cells in Tumor-like Microcapsules
Buehler, A.; Krueger, R.; Monavari, M.; Fuentes-Chandia, M.; Palmisano, R.; Schoedel, J.; Boccaccini, A. R.; Bosserhoff, A. K.; Kappelmann-Fenzl, M.; Letort, G.; Leal-Egana, A.
10.1101/2022.09.22.508846 — bioengineering — Posted on 2022-09-23
1202 PFTK1 kinase regulates axogenesis during development via RhoA activation.
Rodriguez Gonzalez, Y.; Kamkar, F.; Jafar-nejad, P.; Wang, S.; Qu, D.; Sanchez Alvarez, L.; Hawari, D.; Sonnenfeld, M.; Slack, R. S.; Albert, P.; Park, D. S.; Joselin, A.
10.1101/2022.01.11.475789 — neuroscience — Posted on 2022-09-23
1203 Imprinted SARS-CoV-2 humoral immunity induces converging Omicron RBD evolution
Cao, Y.; Jian, F.; Wang, J.; Yu, Y.; Song, W.; Yisimayi, A.; Wang, J.; An, R.; Zhang, N.; Wang, Y.; Wang, P.; Zhao, L.; Sun, H.; Yu, L.; Yang, S.; Niu, X.; Xiao, T.; Gu, Q.; Shao, F.; Hao, X.; Xu, Y.; Jin, R.; Wang, Y.; Xie, X. S.
10.1101/2022.09.15.507787 — immunology — Posted on 2022-09-23
1205 Tumoroscope: a probabilistic model for mapping cancer clones in tumor tissues
Darvish Shafighi, S.; Geras, A.; Jurzysta, B.; Sahaf Naeini, A.; Filipiuk, I.; Raczkowski, L.; Toosi, H.; Koperski, L.; Thrane, K.; Engblom, C.; Mold, J.; Chen, X.; Hartman, J.; Nowis, D.; Carbone, A.; Lagergren, J.; Szczurek, E.
10.1101/2022.09.22.508914 — cancer biology — Posted on 2022-09-23
1206 Proteomics Characteristics Reveal the Risk of T1 Colorectal Cancer Metastasis to Lymph Nodes
Zhuang, A.; Zhuang, A.; Qin, Z.; Zhu, D.; Ren, L.; Wei, Y.; Zhou, P.; Yue, X.; He, F.; Xu, J.; Ding, C.
10.1101/2022.09.22.508997 — cancer biology — Posted on 2022-09-23
1207 eccDB: a comprehensive repository for eccDNA-mediated chromatin contacts in multi-species
Yang, M.; Qiu, B.; He, G.-Y.; Zhou, J.-Y.; Yu, H.-J.; Zhang, Y.-Y.; Li, Y.-S.; Li, T.-S.; Guo, J.-C.; Li, X.-C.; Xie, J.-J.
10.1101/2022.09.22.509011 — bioinformatics — Posted on 2022-09-23
1208 Meta-analysis of (single-cell method) benchmarks reveals the need for extensibility and interoperability
Sonrel, A.; Luetge, A.; Soneson, C.; Mallona Gonzalez, I.; Germain, P.-L.; Knyazev, S.; Gilis, J.; Gerber, R.; Seurinck, R.; Paul, D.; Sonder, E.; Crowell, H. L.; Fanaswala, I.; Al Ajami, A.; Heidari, E.; Schmeing, S.; Milosavljevic, S.; Saeys, Y.; Mangul, S.; Robinson, M. D.
10.1101/2022.09.22.508982 — bioinformatics — Posted on 2022-09-23
1209 Optical modulation of excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes
Vurro, V.; Federici, B.; Ronchi, C.; Sesti, V.; Crasto, S.; Maniezzi, C.; Antognazza, M. R.; Bertarelli, C.; Di Pasquale, E.; Lanzani, G.; Lodola, F.
10.1101/2022.09.22.508828 — bioengineering — Posted on 2022-09-23
1210 Conformable neural interface based on off-stoichiometry thiol-ene-epoxy thermosets
Borda, E.; Airaghi Leccardi, M. J.; Medagoda, D. I.; Zollinger, E. G.; Ghezzi, D.
10.1101/2022.09.22.508978 — bioengineering — Posted on 2022-09-23
1212 Maternal control over caste allocation in the ant Cardiocondyla obscurior
Schultner, E.; Wallner, T.; Dofka, B.; Bruelhart, J.; Heinze, J.; Freitak, D.; Pokorny, T.; Oettler, J.
10.1101/2021.08.13.456267 — evolutionary biology — Posted on 2022-09-23
1213 ADAR2 deaminase activity promotes Th17 effector function and protects against intestine inflammation
Ma, S.; Hao, Y.; Cho, B. S.; Chen, N.; Zheng, A.; Zhang, S.; Sun, G.; Patel, P. R.; Li, Y.; Yee, B. A.; Yeo, G. W.; Zhou, B.; Fu, X.-D.; Huang, W. J. M.
10.1101/2020.09.22.308221 — immunology — Posted on 2022-09-23
1217 One Health Approach for the sampling of different bat species living in a sympatric colony
Perera, T.; Siriwardana, S.; Muzeniek, T.; Becker-Ziaja, B.; Bas, D.; Bayram, F.; Oeruc, M.; Perera, I.; Weerasena, J.; Handunnetti, S.; Schwarz, F.; Premawansa, G.; Premawansa, S.; Yapa, W.; Nitsche, A.; Kohl, C.
10.1101/2022.09.22.508887 — zoology — Posted on 2022-09-23
1218 A CDKB/KRP/FB3 cell cycle core complex functions in rice gametes and zygotes
Xu, H.; Bartley, L.; Libault, M.; Sundaresan, V.; Fu, H.; Russell, S. D.
10.1101/2022.07.12.499798 — cell biology — Posted on 2022-09-23
1219 Temporal dynamics of the multi-omic response to endurance exercise training across tissues
MoTrPAC Study Group, ; Amar, D.; Gay, N. R.; Jean Beltran, P. M.; Adkins, J. N.; Almagro Armenteros, J. J.; Ashley, E.; Avila-Pacheco, J.; Bae, D.; Bararpour, N.; Burant, C.; Clish, C.; Cutter, G.; Dasari, S.; Dennis, C.; Evans, C. R.; Fernandez, F. M.; Gaul, D.; Ge, Y.; Gerszten, R.; Goodyear, L. J.; Hou, Z.; Ilkayeva, O.; Ivanova, A. A.; Jimenez-Morales, D.; Kachman, M. T.; Keshishian, H.; Kraus, W. E.; Lanza, I. R.; Li, J.; Lindholm, M. E.; Lira, A. C.; Many, G. M.; Marwaha, S.; Miller, M. E.; Muehlbauer, M. J.; Nair, K. S.; Nair, V. D.; Natarajan Raja, A.; Newgard, C.; Ortlund, E. A.; Pie
10.1101/2022.09.21.508770 — molecular biology — Posted on 2022-09-23
1224 In vitro characterization of the full-length human dynein-1 cargo adaptor BicD2
Fagiewicz, R.; Crucifix, C.; Deville, C.; Kieffer, B.; Nomine, Y.; Busselez, J.; Rossolillo, P.; Schmidt, H.; Klos, T.
10.1101/2022.01.05.474964 — biochemistry — Posted on 2022-09-23
1227 Glutamatergic Supramammillary Nucleus Neurons Promote Active Coping to Stress
Holloway, S.-A.; Votoupal, M.; Escobedo, A.; Legaria, A.; Ndiokho, I.; Floyd, T.; Kravitz, A. V.; Bruchas, M. R.; Norris, A. J.
10.1101/2022.09.22.507167 — neuroscience — Posted on 2022-09-23
1228 Comparison Between Gradients and Parcellations for Functional Connectivity Prediction of Behavior
Kong, R.; Tan, Y. R.; Wulan, N.; Ooi, L. Q. R.; Farahibozorg, S.-R.; Harrison, S.; Bijsterbosch, J. D.; Bernhardt, B. C.; Eickhoff, S.; Yeo, B. T. T.
10.1101/2022.09.22.509045 — neuroscience — Posted on 2022-09-23
1229 Pathogenic mis-splicing of CPEB4 in schizophrenia
Olla, I.; Pardinas, A. F.; Parras, A.; Hernandez, I. H.; Santos-Galindo, M.; Pico, S.; Callado, L. F.; Elorza, A.; Fernandez-Miranda, G.; Belloc, E.; Walters, J. T. R.; O'Donovan, M.; Toma, C.; Mendez, R.; Meana, J. J.; Owen, M. J.; Lucas, J. J.
10.1101/2022.09.22.508890 — neuroscience — Posted on 2022-09-23
1231 Systematic evaluation of genome sequencing for the assessment of fetal structural anomalies
Lowther, C.; Valkanas, E.; Giordano, J. L.; Wang, H. Z.; Currall, B. B.; O'Keefe, K.; Pierce-Hoffman, E.; Kurtas, N. E.; Whelan, C. W.; Hao, S. P.; Weisburd, B. W.; Jalili, V.; Fu, J.; Wong, I.; Collins, R. L.; Zhao, X.; Austin-Tse, C. A.; Evangelista, E.; Lemire, G.; Aggarwal, V.; Lucente, D.; Gauthier, L. D.; Tolonen, C.; Sahakian, N.; Stevens, C.; An, J.-Y.; Dong, S.; Norton, M. E.; MacKenzie, T.; Devlin, B.; Gilmore, K.; Powell, B.; Brandt, A.; Vetrini, F.; DiVito, M.; Sanders, S. J.; MacArthur, D. G.; Hodge, J. C.; O'Donnell-Luria, A.; Rehm, H.; Vora, N.; Levy, B.; Brand, H.; Wapner, R.;
10.1101/2020.08.12.248526 — genomics — Posted on 2022-09-23
1234 Defining composition and function of the rhizosphere microbiota of barley genotypes exposed to growth-limiting nitrogen supplies
Alegria Terrazas, R.; Robertson-Albertyn, S.; Corral, A. M.; Escudero-Martinez, C.; Kapadia, R.; Balbirnie-Cumming, K.; Morris, J.; Hedley, P. E.; Barret, M.; Torres, G.; Paterson, E.; Baggs, L. M.; Abbott, J.; Bulgarelli, D.
10.1101/605204 — plant biology — Posted on 2022-09-23
1242 Population Genomics of Stone Age Eurasia
Allentoft, M. E.; Sikora, M.; Refoyo-Martinez, A.; Irving-Pease, E. K.; Fischer, A.; Barrie, W.; Ingason, A.; Stenderup, J.; Sjögren, K.-G.; Pearson, A.; Sousa da Mota, B.; Paulsson, B. S.; Halgren, A. S.; Macleod, R.; Schjellerup Jorkov, M. L.; Demeter, F.; Novosolov, M.; Sorensen, L.; Nielsen, P. O.; Henriksen, R. A.; Vimala, T.; McColl, H.; Margaryan, A.; Ilardo, M.; Vaughn, A.; Mortensen, M. F.; Nielsen, A. B.; Hede, M. U.; Rasmussen, P.; Vinner, L.; Renaud, G.; Stern, A. J.; Trolle Jensen, T. Z.; Johannsen, N. N.; Scorrano, G.; Schroeder, H.; Lysdahl, P.; Ramsoe, A.; Skorobogatov, A.; Sc
10.1101/2022.05.04.490594 — evolutionary biology — Posted on 2022-09-23
1243 Identification and structural modeling of the chlamydial RNA polymerase omega subunit
Cheng, A.; Wu, D.; Ghatak, A.; Wang, C.; Feng, D.; Fondell, J. D.; Ebright, R. H.; Fan, H.
10.1101/2022.09.22.509108 — molecular biology — Posted on 2022-09-23
1246 Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic
Lizcano-Perret, B.; Lardinois, C.; Wavreil, F.; Hauchamps, P.; Herinckx, G.; Sorgeloos, F.; Vertommen, D.; Gatto, L.; Michiels, T.
10.1101/2022.06.16.496404 — microbiology — Posted on 2022-09-23
1249 Cas9-mediated endogenous plasmid loss in Borrelia burgdorferi
Takacs, C. N.; Nakajima, Y.; Haber, J. E.; Jacobs-Wagner, C.
10.1101/2022.09.22.509095 — microbiology — Posted on 2022-09-22
1250 ESCRT-dependent STING degradation curtails steady-state and cGAMP-induced signaling
Gentili, M.; Liu, B.; Papanastasiou, M.; Dele-Oni, D.; Schwartz, M. A.; Carlson, R. J.; Al'Khafaji, A.; Krug, K.; Brown, A.; Doench, J. G.; Carr, S. A.; Hacohen, N.
10.1101/2022.09.22.509044 — immunology — Posted on 2022-09-22
1251 The immune response to lumpy skin disease virus in cattle is influenced by inoculation route
Fay, P. C.; Wijesiriwardana, N.; Munyanduki, H.; Sanz-Bernardo, B.; Lewis, I.; Haga, I. R.; Moffat, K.; van Vliet, A. H. M.; Hope, J.; Graham, S.; Beard, P.
10.1101/2022.09.22.509006 — immunology — Posted on 2022-09-22
1252 Designing a Minimal Artificial Glycolytic Pathway
yang, y.; Liu, Y.; zhang, j.; Yang, Q.; Cheng, J.; Chu, H.; Zhao, H.; Luo, M.; Lu, X.; Liu, D.; Sheng, X.; Zhang, Y.-H. P. J.; jiang, h.; Ma, Y.
10.1101/2022.09.22.508994 — synthetic biology — Posted on 2022-09-22
1254 Anticodon-like loop-mediated dimerization in the crystal structures of HdV- like CPEB3 ribozymes
Przytula-Mally, I.; Engilberge, S.; Johannsen, S.; Olieric, V.; Masquida, B.; Sigel, R. K. O.
10.1101/2022.09.22.508989 — biophysics — Posted on 2022-09-22
1256 Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALS
Larrea, D.; Tamucci, K. A.; Kabra, K.; Velasco, K.; Yun, T. D.; Pera, M.; Montesinos, J.; Agrawal, R. R.; Smerdon, J. W.; Lowry, E. R.; Stepanova, A.; Yoval-Sanchez, B.; Galkin, A.; Wichterle, H.; Area-Gomez, E.
10.1101/2022.09.22.508778 — molecular biology — Posted on 2022-09-22
1257 The cell envelope of Thermotogae suggests a mechanism for outer membrane biogenesis
Sexton, D. L.; Hashimi, A.; Sibanda, L.; Beskrovnaya, P.; Huan, T.; Tocheva, E. I.
10.1101/2022.09.22.508938 — microbiology — Posted on 2022-09-22
1258 Genome evolution and transcriptome plasticity associated with adaptation to monocot and eudicot plants in Colletotrichum fungi
Baroncelli, R.; Cobo-Diaz, J. F.; Benocci, T.; Peng, M.; Battaglia, E.; Haridas, S.; Andreopoulos, W.; LaButti, K.; Pangilinan, J.; Lipzen, A.; Koriabine, M.; Bauer, D.; Le Floch, G.; Makela, M. R.; Drula, E.; Henrissat, B.; Grigoriev, I. V.; Crouch, J. A.; de Vries, R. P.; Sukno, S. A.; Thon, M. R.
10.1101/2022.09.22.508453 — microbiology — Posted on 2022-09-22
1260 Exploitation of ATP-sensitive potassium ion (KATP) channels by HPV promotes cervical cancer cell proliferation by contributing to MAPK/AP-1 signalling
Scarth, J. A.; Wasson, C. W.; Patterson, M. R.; Evans, D.; Barba-Moreno, D.; Carden, H.; Whitehouse, A.; Mankouri, J.; Samson, A.; Morgan, E. L.; Macdonald, A.
10.1101/2022.09.22.508991 — microbiology — Posted on 2022-09-22
1262 Strand-biased circularizing integrative elements spread tmexCD-toprJ gene clusters encoding RND-type multidrug efflux pumps by repeated transpositions
Dao, T. D.; Yano, H.; Takemura, T.; Hirabayashi, A.; Trang, L. T.; Tran, H. H.; Shibayama, K.; Hasebe, F.; Kasuga, I.; Suzuki, M.
10.1101/2022.09.22.508988 — microbiology — Posted on 2022-09-22
1264 The Phosphate Deprivation Response is Mediated by an Interaction between Brassinosteroid Signaling and Zinc in Tomato
Demirer, G. S.; Gibson, D. J.; Yue, X.; Pan, K.; Elishav, E.; Khandal, H.; Horev, G.; Tarkowska, D.; Canto-Pastor, A.; Kong, S.; Maloof, J.; Savaldi-Goldstein, S.; Brady, S.
10.1101/2022.09.21.508943 — plant biology — Posted on 2022-09-22
1265 Proton exchange in the nitrate vacuolar transporter AtCLCa is required for growth and nitrogen use efficiency
Hodin, J.; Lind, C.; Marmagne, A.; Espagne, C.; Bianchi, M. W.; De Angeli, A.; Abou Choucha, F.; Bourge, M.; Chardon, F.; Thomine, S.; Filleur, S.
10.1101/2022.09.21.508937 — plant biology — Posted on 2022-09-22
1266 Palbociclib interferes with replication origin firing in a pRb independent manner
Kim, S.-J.; Maric, C.; Briu, l.-m.; Fauchereau, F.; Baldacci, G.; Debatisse, M.; KOUNDRIOUKOFF, S.; cadoret, J. C.
10.1101/2022.09.21.508850 — cancer biology — Posted on 2022-09-22
1268 Screening and Development of Constitutively Synergistic Combination Drug Formulations for T Cell Acute Lymphoblastic Leukemia
Kelvin, J. M.; Zhang, D. Y.; Williams, E. K.; Moore, S. G.; Birnbaum, L. A.; Zecca, H.; Wang, X.; Jain, J.; Qui, M.; Jui, N. T.; Fu, H.; Du, Y.; Kemp, M. L.; Lam, W. A.; DeRyckere, D.; Graham, D. K.; Dreaden, E. C.
10.1101/2022.09.21.508196 — bioengineering — Posted on 2022-09-22
1269 The origin of a new chromosome in gerbils
Brekke, T. D.; Papadopulos, A. S.; Julia, E.; Fornas, O.; Fu, B.; Yang, F.; de la Fuente, R.; Page, J.; Baril, T.; Hayward, A.; Mulley, J.
10.1101/2022.09.21.508825 — genomics — Posted on 2022-09-22
1271 Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range
Hata, J.; Nakae, K.; Tsukada, H.; Woodward, A.; Haga, Y.; Iida, M.; Uematsu, A.; Seki, F.; Ichinohe, N.; Gong, R.; Kaneko, T.; Yoshimaru, D.; Watakabe, A.; Abe, H.; Tani, T.; skibbe, h.; Maeda, M.; Papazian, F.; Hagiya, K.; Kishi, N.; Shimogori, T.; Yamamori, T.; Okano, H. j.; Okano, H.
10.1101/2022.09.21.508952 — neuroscience — Posted on 2022-09-22
1272 Brain mapping and spatial protein profiling reveal functional connectivity deficits and molecular changes following repetitive mild traumatic brain injury in wild-type mice.
Ravi, S.; Criado-Marrero, M.; Barroso, D.; Braga, I. M.; Bolen, M.; Rubinovich, U.; Hery, G. P.; Grudny, M. M.; Koren, J.; Prokop, S.; Febo, M.; Abisambra, J. F.
10.1101/2022.09.21.508917 — neuroscience — Posted on 2022-09-22
1275 Carcinoma associated mesenchymal stem cells promote ovarian cancer metastasis by increasing tumor heterogeneity through direct mitochondrial transfer
Pressimone, C.; Frisbie, L. G.; Dyer, E.; Baruwal, R.; Gorecki, G.; Javed, Z.; St. Croix, C.; Watkins, S. C.; Calderon, M.; Atiua, H. I.; Hempel, N.; Pearson, A. T.; Coffman, L.
10.1101/2022.09.21.506345 — cancer biology — Posted on 2022-09-22
1277 Topological Gelation of Reconnecting Polymers
Bonato, A.; Marenduzzo, D.; Michieletto, D.; Orlandini, E.
10.1101/2022.09.21.508941 — biophysics — Posted on 2022-09-22
1278 Effective drug combinations targeting driver KRAS mutations in non-small cell lung cancer
BRUGGEMANN, L.; Falls, Z.; Mangione, W.; Schwartz, S. A.; Battaglia, S.; Aalinkeel, R.; Mahajan, S. D.; Samudrala, R.
10.1101/2022.09.21.508953 — bioinformatics — Posted on 2022-09-22
1279 Syndecan-4 Proteoliposomes Enhance Revascularization in a Rabbit Hind Limb Ischemia Model of Peripheral Ischemia
Sligar, A.; Howe, G.; Goldman, J.; Felli, P.; Gomez-Hernandez, A.; Takematsu, E.; Veith, A.; Desai, S.; Riley, W.; Singeetham, R.; Mei, L.; Callahan, G.; Ashirov, D.; Smalling, R.; Baker, A.
10.1101/2022.09.21.508898 — bioengineering — Posted on 2022-09-22
1280 New estimates of genome size in Orthoptera and their evolutionary implications
Hawlitschek, O.; Sadilek, D.; Lara-Sophie, D.; Buchholz, K.; Noori, S.; Baez, I. L.; Wehrt, T.; Brozio, J.; Travnicek, P.; Seidel, M.; Husemann, M.
10.1101/2022.09.21.508865 — genomics — Posted on 2022-09-22
1283 Heme-induced genes facilitate endosymbiont (Sodalis glossinidius) colonization of the tsetse fly (Glossina morsitans) midgut
Weiss, B. L.; Runyen-Janecky, L. J.; Scheutzow, J.; Farsin, R.; Cabo, L. F.; Kuhn, K. M.; Amador, R.; D'Souza, S. J.; Vigneron, A.; Wall, K. E.
10.1101/2022.09.22.508973 — microbiology — Posted on 2022-09-22
1286 Mouse lung Tissue Resident Memory (TRM) CD8 T cell subsets have distinct metabolic profiles from each other and from non-TRM
Sportiello, M.; Poindexter, A.; Reilly, E. C.; Geber, A.; Lambert Emo, K.; Jones, T. N.; Topham, D. J.
10.1101/2022.09.21.508875 — immunology — Posted on 2022-09-22
1287 Transcription factor TFII-I fine tunes innate properties of B lymphocytes
Singh, A.; Kaileh, M.; De, S.; Mazan-Mamczarz, K.; Bayarsaihan, D.; Sen, R.; Roy, A.
10.1101/2022.09.21.508949 — immunology — Posted on 2022-09-22
1288 Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics
Robinson, M. L.; Glass, D. R.; Duran, V.; Rojas, O.; Sanz, A. M.; Consuegra, M.; Sahoo, M. K.; Hartmann, F.; Bosse, M.; Ramirez, R. M. G.; Bueno, N.; Pinsky, B. A.; Montoya, J. G.; Maecker, H.; Cardenas, M.; Villar, L.; Garrido, E. R.; Rosso, F.; Bendall, S. C.; Einav, S.
10.1101/2022.09.21.508901 — immunology — Posted on 2022-09-22
1290 SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination
Iram, T.; Garcia, M. A.; Amand, J.; Kaur, A.; Iyer, M.; Lam, M.; Ambiel, N.; Keller, A.; Wyss-Coray, T.; Kern, F.; Zuchero, J. B.
10.1101/2022.09.21.508765 — neuroscience — Posted on 2022-09-22
1291 Irregular optogenetic stimulation waveforms can induce naturalistic patterns of hippocampal spectral activity
Cole, E. R.; Eggers, T. E.; Weiss, D.; Connolly, M. J.; Gombolay, M. C.; Laxpati, N. G.; Gross, R. E.
10.1101/2022.09.21.508935 — neuroscience — Posted on 2022-09-22
1293 Wound healing and anti-inflammatory potential of Ajuga bracteosa-conjugated silver nanoparticles in Balb/c mice
Andleeb, S.; Nazer, S.; Alomar, S. Y.; Ahmad, N.; Khan, I.; Raza, A.; Awan, U. A.; Raja, S. A.
10.1101/2022.09.21.508872 — zoology — Posted on 2022-09-22
1295 Alternative proteoforms and proteoform-dependent assemblies in humans and plants
McWhite, C. D.; Sae-Lee, W.; Yuan, Y.; Mallam, A.; Gort-Frietas, N. A.; Ramundo, S.; Onishi, M.; Marcotte, E. M.
10.1101/2022.09.21.508930 — systems biology — Posted on 2022-09-22
1296 In situ single-cell analysis of canonical breast cancer biomarkers: phenotypic heterogeneity and implications on response to HER2 targeting agents.
Serna, G.; Garcia, E.; Fasani, R.; Guardia, X.; Pascual, T.; Pare, L.; Ruiz-Pace, F.; Llombart-Cussac, A.; Cortes, J.; Prat, A.; Nuciforo, P. G.
10.1101/2022.09.21.508826 — pathology — Posted on 2022-09-22
1298 Spatially Resolved Transcriptomics Deconvolutes Histological Prognostic Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases
Wood, C. S.; Pennel, K.; Leslie, H.; Legrini, A.; Cameron, A.; Melissourgou-Syka, L.; Quinn, J.; Van Wyk, H.; Hay, J.; Roseweir, A.; Nixon, C.; Roxburgh, C.; McMillan, D.; Biankin, A.; Sansom, O. J.; Horgan, P.; Edwards, J.; Steele, C.; Jamieson, N.
10.1101/2022.09.21.508569 — cancer biology — Posted on 2022-09-22
1301 MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites
Wang, C.; Dong, Y.; Oberstaller, J.; Li, C.; Zhang, M.; Gibbons, J.; Pires, C. V.; Zhu, L.; Jiang, R.; Kim, K.; Miao, J.; Otto, T. D.; Cui, L.; Adams, J. H.; Liu, X.
10.1101/2022.09.21.508539 — bioinformatics — Posted on 2022-09-22
1304 Efficient estimation of time-dependent functional connectivity using Structural Connectivity constraints
Hernandez, H.; Araya, D.; Gonzalez, L. L.; Roman, C.; Trujillo-Barreto, N.; Guevara, P.; El-Deredy, W.
10.1101/2022.09.21.508847 — bioinformatics — Posted on 2022-09-22
1305 Profiling emergent behaviors from single-cell motility
Maity, D.; Kamat, P.; Zamponi, N.; Jayatilaka, H.; Giri, A.; Du, W.; Johnston, A.; Starich, B.; Karl, M.; Agrawal, A.; Riley, D.; Venturitti, L.; Melnick, A.; Cerchietti, L.; Walston, J.; Phillip, J. M.
10.1101/2022.09.21.508955 — bioengineering — Posted on 2022-09-22
1306 Shape-shifting microgel automata controlled by DNA sequence instructions
Shi, R.; Chen, K.-L.; Fern, J.; Deng, S.; Liu, Y.; Scalise, D.; Huang, Q.; Cowan, N.; Gracias, D.; Schulman, R.
10.1101/2022.09.21.508918 — bioengineering — Posted on 2022-09-22
1307 Targeted Protein Degradation via Nanoparticles
Liu, Y.; Liu, R.; Dong, J.; Xia, X.; Yang, H.; Wei, S.; Fan, L.; Fang, M.; Zou, Y.; Zheng, M.; Leong, K. W.; Shi, B.
10.1101/2022.09.21.508905 — bioengineering — Posted on 2022-09-22
1308 Ribosomal protein with conserved function has entirely different structures in different organisms
Schierholz, L.; Brown, C. R.; Helena-Bueno, K.; Uversky, V. N.; Barandun, J.; Melnikov, S. V.
10.1101/2022.09.21.508910 — evolutionary biology — Posted on 2022-09-22
1310 From southern Africa and beyond: historical biogeography of the Ledebouriinae (Scilloideae, Asparagaceae)
Howard, C. C.; Nanyeni, L.; Mollel, N.; Chuba, D.; Zuntini, A. R.; Malakasi, P.; Harvey, T. S.; Cellinese, N.
10.1101/2022.09.21.508857 — evolutionary biology — Posted on 2022-09-22
1316 Crossing-over decision landscape in maize
Zelkowski, M.; Wang, M.; Sun, Q.; Pillardy, J.; Kianian, P. M.; Kianian, S.; Chen, C.; Pawlowski, W. P.
10.1101/2022.09.21.508771 — plant biology — Posted on 2022-09-22
1317 Transpiration and water use efficiency of sorghum canopies have a large genetic variability and are positively related under naturally high evaporative demand.
Pilloni, R.; Kakkera, A.; El Ghazzal, Z.; Kar, S.; Kumar, A. A.; Hajjarpoor, A.; Affortit, P.; Ribiere, W.; Kholova, J.; Tardieu, F.; Vadez, V.
10.1101/2022.09.21.508841 — physiology — Posted on 2022-09-22
1318 Mortality without springing a leak: Locust gut epithelia do not become more permeable to fluorescent dextran and bacteria in the cold
El-Saadi, M. I.; Brzezinski, K.; Hinz, A.; Phillips, L.; Wong, A.; Gerber, L.; Overgaard, J.; MacMillan, H. A.
10.1101/2022.09.21.508851 — physiology — Posted on 2022-09-22
1320 Rapid and sensitive single cell RNA sequencing with SHERRY2
Di, L.; Liu, B.; Lyu, Y.; Zhao, S.; Pang, Y.; Zhang, C.; Wang, J.; Qi, H.; Shen, J.; Huang, Y.
10.1101/2021.12.25.474161 — genomics — Posted on 2022-09-22
1323 DNA damage response signaling to mitochondria drives senescence
Yamauchi, S.; Sugiura, Y.; Yamaguchi, J.; Zhou, X.; Odawara, T.; Fukaya, S.; Naguro, I.; Uchiyama, Y.; Ichijo, H.
10.1101/2022.09.22.509001 — cell biology — Posted on 2022-09-22
1324 Development of a Novel Air-Liquid Interface Airway Tissue Equivalent Model for In Vitro Respiratory Modeling Studies
Leach, T.; Gandhi, U.; Reeves, K.; Stumpf, K.; Okuda, K.; Marini, F.; Walker, S.; Chan, J.; Cox, L. A.; Atala, A.; Murphy, S. V.
10.1101/2022.09.21.508886 — cell biology — Posted on 2022-09-22
1325 Comparative virome analysis of individual shedding routes of Miniopterus fuliginosus bats inhabiting the Wavul Galge Cave, Sri Lanka
Muzeniek, T.; Perera, T.; Siriwardana, S.; Bas, D.; Bayram, F.; Oeruc, M.; Becker-Ziaja, B.; Perera, I.; Weerasena, J.; Handunnetti, S.; Schwarz, F.; Premawansa, G.; Premawansa, S.; Yapa, W.; Nitsche, A.; Kohl, C.
10.1101/2022.09.21.508883 — molecular biology — Posted on 2022-09-22
1327 SARS-CoV-2 Omicron boosting induces de novo B cell response in humans
Alsoussi, W. B.; Malladi, S. K.; Zhou, J. Q.; Liu, Z.; Ying, B.; Kim, W.; Schmitz, A. J.; Lei, T.; Horvath, S. C.; Sturtz, A. J.; McIntire, K. M.; Evavold, B.; Han, F.; Scheaffer, S. M.; Fox, I. F.; Parra-Rodriguez, L.; Nachbagauer, R.; Nestorova, B.; Chalkias, S.; Farnsworth, C. W.; Klebert, M. K.; Pusic, I.; Strnad, B. S.; Middleton, W. D.; Teefey, S. A.; Whelan, S. P. J.; Diamond, M. S.; Paris, R.; O'Halloran, J. A.; Presti, R. M.; Turner, J. S.; Ellebedy, A. H.
10.1101/2022.09.22.509040 — immunology — Posted on 2022-09-22
1329 Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome
Tsu, B. V.; Agarwal, R.; Gokhale, N. S.; Kulsuptrakul, J.; Ryan, A. P.; Castro, L. K.; Beierschmitt, C. M.; Turcotte, E. A.; Fay, E. J.; Vance, R. E.; Hyde, J. L.; Savan, R.; Mitchell, P. S.; Daugherty, M. D.
10.1101/2022.09.21.508960 — immunology — Posted on 2022-09-22
1330 Dynamic refinement of behavioral structure mediates dopamine-dependent credit assignment
Tang, J. C. Y.; Paixao, V.; Carvalho, F.; Silva, A.; Klaus, A.; Alves da Silva, J.; Costa, R. M.
10.1101/2022.09.22.507905 — neuroscience — Posted on 2022-09-22
1331 Calibration of crop phenology models: Going beyond recommendations
Wallach, D.; Palosuo, T.; Thorburn, P.; Mielenz, H.; Buis, S.; Hochman, Z.; Gourdain, E.; Garcia, C.; Andrianasolo, F.; Dumont, B.; Ferrise, R.; Gaiser, T.; Gayler, S.; Hiremath, S.; Horan, H.; Hoogenboom, G.; Jansson, P.-E.; Jing, Q.; Qian, B.; Harrison, M.; Justes, E.; Kersebaum, K.-C.; Launay, M.; Lewan, E.; Mequanint, F.; Liu, K.; Moriondo, M.; Nendel, C.; Padovan, G.; Schuetze, N.; Seserman, D.-M.; Souissi, A.; Shelia, V.; Specka, X.; Srivastava, A. K.; Trombi, G.; Weber, T.; Weihermueller, L.; Woehling, T.; Seidel, S.
10.1101/2022.06.08.495355 — plant biology — Posted on 2022-09-22
1334 MATEdb, a data repository of high-quality metazoan transcriptome assemblies to accelerate phylogenomic studies
Fernandez, R.; Tonzo, V.; Simon Guerrero, C.; Lozano-Fernandez, J.; Martinez-Redondo, G. I.; Balart-Garcia, P.; Aristide, L.; Eleftheriadi, K.; Vargas-Chavez, C.
10.1101/2022.07.18.500182 — evolutionary biology — Posted on 2022-09-22
1335 Population size fluctuations can drive multitrait diversification in marine diatoms
Hinners, J.; Argyle, P. A.; Walworth, N. G.; Doblin, M. A.; Levine, N. M.; Collins, S.
10.1101/2022.04.08.487611 — evolutionary biology — Posted on 2022-09-22
1336 Patterning and growth are coordinated early in the cell cycle
Winter, C. M.; Szekely, P.; Belcher, H.; Carter, R.; Jones, M.; Fraser, S. E.; Truong, T. V.; Benfey, P. N.
10.1101/2022.09.22.508753 — developmental biology — Posted on 2022-09-22
1337 The relationship between PD-L1 and quiescence in melanocyte stem cell aging.
Palmer, J. W.; Villavicencio, K. M.; Idris, M.; Weddle, D.; Filipp, F. V.; NISC Comparative Sequencing Program - NHGRI, ; Pavan, W. J.; Harris, M. L.
10.1101/2022.09.22.508528 — cell biology — Posted on 2022-09-22
1340 In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury.
Giannakopoulos, S.; Strange, D. P.; Jiyarom, B.; Abdelaal, O.; Bradshaw, A. W.; Nerurkar, V. R.; Ward, M. A.; Bakse, J.; Yap, J.; Vanapruks, S.; Boisvert, W.; Tallquist, M.; Shikuma, C.; Sadri-Ardekani, H.; Clapp, P.; Murphy, S.; Verma, S.
10.1101/2022.09.21.508904 — microbiology — Posted on 2022-09-22
1342 Evolution of antibody immunity following Omicron BA.1 breakthrough infection
Kaku, C. I.; Starr, T. N.; Zhou, P.; Dugan, H. L.; Khalife, P.; Song, G.; Champney, E. R.; Mielcarz, D. W.; Geoghegan, J. C.; Burton, D. R.; Andrabi, R.; Bloom, J. D.; Walker, L. M.
10.1101/2022.09.21.508922 — immunology — Posted on 2022-09-22
1343 Self-produced hydrogen sulfide improves ethanol fermentation by Saccharomyces cerevisiae and other yeast species
Espinoza-Simon, E.; Moreno-Alvarez, P.; Nieto-Zaragoza, E.; Ricardez-Garcia, C.; Rios-Castro, E.; Uribe-Carvajal, S.; Torres-Quiroz, F.
10.1101/2022.08.09.503431 — biochemistry — Posted on 2022-09-22
1344 The rapid evolution of flagellar ion-selectivity in experimental populations of E. coli
Ridone, P.; Ishida, T.; Lin, A.; Humphreys, D. T.; Giannoulatou, E.; Sowa, Y.; Baker, M. A.
10.1101/2021.01.26.427765 — microbiology — Posted on 2022-09-22
1346 origamiFISH allows universal, label-free, single molecule visualization of DNA origami nanodevices across biological samples
Wang, W. X.; Douglas, T. R.; Zhang, H.; Bhattacharya, A.; Rothenbroker, M.; Jia, Z.; Muffat, J.; Li, Y.; Chou, L. Y. T.
10.1101/2022.09.19.508533 — synthetic biology — Posted on 2022-09-22
1347 Lost In The Forest
Smith, H. L.; Biggs, P. J.; French, N. P.; Smith, A. N.; Marshall, J. C.
10.1101/2022.09.12.507676 — bioinformatics — Posted on 2022-09-22
1349 3D bioengineered neural tissue generated from patient-derived iPSCs develops time-dependent phenotypes and transcriptional features of Alzheimer's disease
Lomoio, S.; Pandey, R.; Rouleau, N.; Menicacci, B.; Kim, W.; Cantley, W.; Haydon, P.; Bennett, D.; Young-Pearse, T.; Carter, G.; Kaplan, D.; Tesco, G.
10.1101/2022.07.21.501004 — neuroscience — Posted on 2022-09-22
1354 Predicting Peptide HLA-II Presentation Using Immunopeptidomics, Transcriptomics and Deep Multimodal Learning
ElAbd, H.; Wendorff, M.; Koudelka, T.; Hentschker, C.; Kamps, A.-K.; Priess, C.; Wienbrandt, L.; Degenhardt, F.; Steiert, T. A.; Bacher, P.; Mathur, P.; Ellinghaus, D.; Völker, U.; Tholey, A.; Lenz, T. L.; Franke, A.
10.1101/2022.09.20.508681 — bioinformatics — Posted on 2022-09-22
1357 Theoretical design of a space bioprocessing system to produce recombinant proteins
Soundararajan, M.; Paddock, M. B.; Dougherty, M.; Jones, H. W.; Hogan, J. A.; Donovan, F. M.; Galazka, J. M.; Settles, A. M.
10.1101/2022.09.20.508767 — bioengineering — Posted on 2022-09-22
1358 Canary in the cardiac-valve coal mine: Flow velocity and inferred shear during prosthetic valve closure -predictors of blood damage and clotting
Scotten, L. N.; Siegel, R.; Blundon, D. J.; Deutsch, M.-A.; Martin, T. R. P.; Dutton, J. W.; Kolahdouz, E. M.; Griffith, B. E.
10.1101/2022.06.23.497372 — bioengineering — Posted on 2022-09-22
1359 A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation
Vides, E. G.; Adhikari, A.; Chiang, C. Y.; Lis, P.; Purlyte, E.; Limouse, C.; Shumate, J. L.; Lasso, E. S.; Dhekne, H. S.; Alessi, D. R.; Pfeffer, S. R.
10.1101/2022.04.25.489459 — biochemistry — Posted on 2022-09-22
1360 Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2
Planchais, C.; Reyes-Ruiz, A.; Lacombe, R.; Zarantonello, A.; Lecerf, M.; Revel, M.; Roumenina, L. T.; Atanasov, B. P.; Mouquet, H.; Dimitrov, J. D.
10.1101/2022.06.11.495733 — biochemistry — Posted on 2022-09-22
1361 Audiovisual cues must be predictable and win-paired to drive risky choice
Hathaway, B. A.; Kim, D. R.; Malhas, S. B. A.; Hrelja, K. M.; Kerker, L.; Hynes, T. J.; Harris, C. B. W.; Langdon, A. J.; Winstanley, C. A.
10.1101/2022.09.20.507379 — animal behavior and cognition — Posted on 2022-09-22
1362 Accelerating Minimap2 for accurate long read alignment on GPUs
Sadasivan, H.; Maric, M.; Dawson, E.; Iyer, V.; Israeli, J.; Narayanasamy, S.
10.1101/2022.03.09.483575 — genomics — Posted on 2022-09-22
1368 Anthropogenic supply of nutrients in a wildlife reserve may compromise conservation success
Abraham, A. J.; Duvall, E.; le Roux, E.; Ganswindt, A.; Clauss, M.; Doughty, C.; Webster, A.
10.1101/2022.09.20.508584 — ecology — Posted on 2022-09-22
1373 Nipah virus Bangladesh infection elicits organ-specific innate and inflammatory responses in the marmoset model
Stevens, C. S.; Lowry, J.; Juelich, T.; Atkins, C.; Johnson, K.; Smith, J. K.; Panis, M.; Ikegame, T.; tenOever, B.; Freiberg, A. N.; Lee, B.
10.1101/2021.10.11.463955 — microbiology — Posted on 2022-09-22
1374 Implications of the 375W mutation for HIV-1 tropism and vaccine development.
Verdejo-Torres, O.; Vargas-Pavia, T.; Fatima, S.; Clapham, P. R.; Duenas-Decamp, M. J.
10.1101/2022.08.29.505747 — microbiology — Posted on 2022-09-22
1375 Genome characterization of monkeypox cases detected in India: Identification of three sub clusters among A.2 lineage
Shete, A. M.; Yadav, P. D.; Kumar, A.; Patil, S.; Patil, D. Y.; Joshi, Y.; Majumdar, T.; Relhan, V.; Sahay, R. R.; Vasu, M.; Gawande, P.; Verma, A.; Kumar, A.; Dhakad, S.; Krishnan, A. B.; Chenayil, S.; Kumar, S.; Abraham, P.
10.1101/2022.09.16.507742 — microbiology — Posted on 2022-09-22
1378 The logic of recurrent circuits in the primary visual cortex
Oldenburg, I. A.; Hendricks, W. D.; Handy, G.; Shamardani, K.; Bounds, H. A.; Doiron, B.; Adesnik, H.
10.1101/2022.09.20.508739 — neuroscience — Posted on 2022-09-22
1379 Generalization of contextual fear is sex-specifically affected by high salt intake
Beaver, J. N.; Weber, B. L.; Ford, M. T.; Anello, A. E.; Ruffin, K. M.; Kassis, S. K.; Gilman, L.
10.1101/2022.09.20.508397 — neuroscience — Posted on 2022-09-22
1381 To start or to discontinue the pill - changes in progestogens reflected by resting-state connectivity and positive mood
Kimmig, A.-C. S.; Friedrich, P.; Drotleff, B.; Laemmerhofer, M.; Sundstrom-Poromaa, I.; Weis, S.; Derntl, B.
10.1101/2022.09.21.508780 — neuroscience — Posted on 2022-09-22
1382 The spatio-temporal architecture of everyday manual behavior
Sili, D.; De Giorgi, C.; Pizzuti, A.; Spezialetti, M.; de Pasquale, F.; Betti, V.
10.1101/2022.09.21.508833 — neuroscience — Posted on 2022-09-22
1384 Multi-omics biomarkers aid prostate cancer prognostication
Xu, Z.; Omar, M.; Benedetti, E.; Rosenthal, J.; Umeton, R.; Krumsiek, J.; Pomerantz, M.; Imada, E.; Loda, M.; Marchionni, L.
10.1101/2022.09.20.508244 — systems biology — Posted on 2022-09-22
1385 Comprehensive characterization of multi-omic landscapes between gut-microbiota metabolites and the G-protein-coupled receptors in Alzheimer's disease
Qiu, Y.; Hou, Y.; Zhou, Y.; Xu, J.; Bykova, M.; Leverenz, J. B.; Pieper, A. P.; Nussinov, R.; Caldwell, J. Z. K.; Brown, M.; Cheng, F.
10.1101/2022.09.20.508759 — systems biology — Posted on 2022-09-22
1387 RNA degradation heavily impacts mRNA co-expression
Garcia Blay, O.; Verhagen, P.; Martin, B.; Hansen, M. M. K.
10.1101/2022.09.21.508820 — systems biology — Posted on 2022-09-22
1392 Single cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia
Robinson, T. T.; Bowman, R. L.; Persaud, S.; Liu, Y.; Gao, Q.; Zhang, J.; Sun, X.; Miles, L. A.; Cai, S. F.; Sciambi, A.; Llanso, A.; Christopher, F. A.; Goldberg, A. D.; Dogan, A.; Roshal, M.; Levine, R.; Xiao, W.
10.1101/2022.09.20.508786 — pathology — Posted on 2022-09-22
1393 Host abundance and heterogeneity in infectiousness determine extent of the environmental reservoir
Laggan, N. A.; Parise, K. L.; White, J. P.; Kaarakka, H. M.; Redell, J. A.; DePue, J. E.; Scullon, W. H.; Kath, J.; Foster, J. T.; Kilpatrick, A. M.; Langwig, K. E.; Hoyt, J. R.
10.1101/2022.09.20.508714 — ecology — Posted on 2022-09-22
1395 T cell-instructed inflammation drives immune checkpoint inhibitor therapy resistance
Cho, N. W.; Guldberg, S. M.; Kim, E. J.; Hiam-Galvez, K. J.; Wai, K.; Levine, L. S.; Nabet, B. Y.; DeBarge, R.; Yee, J. L.; Ashitey, N. A.; Tenvooren, I.; Spitzer, M. H.
10.1101/2022.09.20.508732 — immunology — Posted on 2022-09-22
1397 Choice seeking is motivated by the intrinsic need for personal control
Munuera, J.; Ribes Agost, M.; Bendetowicz, D.; Kerebel, A.; Chambon, V.; Lau, B.
10.1101/2022.09.20.508669 — neuroscience — Posted on 2022-09-22
1398 Hyperthermia elevates brain temperature and improves behavioural signs in animal models of Autism spectrum disorder.
Lopez-Rodriguez, A. B.; Murray, C.; Kealy, J.; Towns, C.; Nazmi, A.; Arnold, L.; Doran, M.; Lowry, J.; Cunningham, C.
10.1101/2022.09.20.508692 — neuroscience — Posted on 2022-09-22
1402 Pre- and post-task resting-state differs in clinical populations
Lor, C. S.; Zhang, M.; Karner, A.; Steyrl, D.; Sladky, R.; Scharnowski, F.; Haugg, A.
10.1101/2022.09.20.508750 — neuroscience — Posted on 2022-09-22
1403 Electroencephalogram Data Collection for Student Engagement Analysis with Audio-Visual Content
Upadhyay, R.; Singh, M.; Mishra, S.; Mehta, J.; Bansal, A.; Baranwal, M.; Kumar, V.
10.1101/2022.09.20.508656 — neuroscience — Posted on 2022-09-22
1406 Is phase-dependent stability related to phase-dependent gait robustness?
Jin, J.; Kistemaker, D.; van Dieen, J. H.; Daffertshofer, A.; Bruijn, S. M.
10.1101/2022.09.20.508663 — physiology — Posted on 2022-09-22
1410 Dynamic Kinetic Models Capture Cell-Free Metabolism for Improved Butanol Production
Martin, J. P.; Rasor, B. J.; DeBonis, J.; Karim, A. S.; Jewett, M. C.; Tyo, K. E. J.; Broadbelt, L. J.
10.1101/2022.09.20.508127 — synthetic biology — Posted on 2022-09-22
1412 Molecular determinants of dynamic protein-protein interactions in the functional cycle of the membrane protein DsbD
Stelzl, L. S.; Kritsiligkou, P.; Mehdipour, A. R.; Baldwin, A. J.; Ferguson, S. J.; Mavridou, D. A. I.; Sansom, M. S. P.; Redfield, C.
10.1101/2022.09.07.506916 — biophysics — Posted on 2022-09-22
1413 The recovery of plant community composition following passive restoration across spatial scales
Ladouceur, E.; Isbell, F.; Clark, A. T.; Harpole, W. S.; Reich, P. B.; Tilman, G. D.; Chase, J. M.
10.1101/2022.04.14.488351 — ecology — Posted on 2022-09-22
1415 Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation
Linares, R.; Arnaud, C.-A.; Effantin, G.; Darnault, C.; Epalle, N. H.; Boeri Erba, E.; Schoehn, G.; Breyton, C.
10.1101/2022.09.20.507954 — microbiology — Posted on 2022-09-22
1416 Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans
Locher, V.; Park, S.; Bunis, D.; Makredes, S.; Burt, T. D.; Fragiadakis, G. K.; Halkias, J.
10.1101/2022.09.19.508328 — immunology — Posted on 2022-09-22
1420 Multi-lingual multi-platform investigations of online trade in jaguar parts
Polisar, J.; Davies, C.; Morcatty, T.; da Silva, M.; Zhang, S.; Duchez, K.; Madrid, J.; Lambert, A. E.; Gallegos, A.; Delgado, M.; Nguyen, H.; Wallace, R.; Arias, M.; Nijman, V.; Ramnarace, J.; Pennell, R.; Novelo, Y.; Rumiz, D.; Rivero, K.; Murillo, Y.; Salas, M. N.; Kretser, H.; Reuter, A.
10.1101/2022.09.19.508455 — ecology — Posted on 2022-09-22
1422 Incoherent collective cell chemotaxis in a zebrafish model of branchio-oto-renal syndrome
Lopez-Schier, H.; Hammerschmidt, M.; Kawakami, K.; Pinto Teixeira, F.; Miranda Rodriguez, J. R.; Borges, A.; Wibowo, I.
10.1101/2021.01.27.428404 — developmental biology — Posted on 2022-09-22
1423 Nanoscale structural organization and stoichiometry of the budding yeast kinetochore
Cieslinski, K.; Wu, Y.-L.; Nechyporenko, L.; Hoerner, S. J.; Conti, D.; Skruzny, M.; Ries, J.
10.1101/2021.12.01.469648 — cell biology — Posted on 2022-09-22
1427 Genome-wide characterization of the common bean kinome: catalog and insights into expression patterns and genetic organization
Aono, A. H.; Pimenta, R. J. G.; Dambroz, C. M. d. S.; Costa, F. C. L.; Kuroshu, R. M.; de Souza, A. P.; Pereira, W. A.
10.1101/2022.08.05.503001 — plant biology — Posted on 2022-09-22
1429 DeepIFC: virtual fluorescent labeling of blood cells in imaging flow cytometry data with deep learning
Timonen, V. A.; Kerkela, E.; Impola, U.; Penna, L.; Partanen, J.; Kilpivaara, O.; Arvas, M.; Pitkanen, E.
10.1101/2022.08.10.503433 — bioinformatics — Posted on 2022-09-22
1435 Corticothalamic Neurons in Motor Cortex Have a Permissive Role in Motor Execution
Carmona, L. M.; Tun, L. T.; Kim, A.; Shiao, R.; Kissner, M. D.; Menon, V.; Costa, R. M.
10.1101/2022.09.20.508799 — neuroscience — Posted on 2022-09-22
1437 Conserved coexpression at single cell resolution across primate brains
Suresh, H.; Crow, M.; Jorstad, N.; Hodge, R.; Lein, E.; Dobin, A.; Bakken, T.; Gillis, J.
10.1101/2022.09.20.508736 — systems biology — Posted on 2022-09-22
1440 Conserved allosteric inhibition mechanism in SLC1 transporters
Dong, Y.; Wang, J.; Garibsingh, R.-A.; Hutchinson, K.; Shi, Y.; Eisenberg, G.; Yu, X.; Schlessinger, A.; Grewer, C.
10.1101/2022.09.21.508810 — biophysics — Posted on 2022-09-22
1443 QTL mapping of the narrow-branch "Pendula" phenotype in Norway spruce (Picea abies L. Karst.)
Gil Munoz, F.; Bernhardsson, C.; Ranade, S. S.; Scofield, D. G.; Pulkkinen, P. O.; Ingvarsson, P. K.; Garcia-Gil, M. R.
10.1101/2022.09.19.508593 — genomics — Posted on 2022-09-22
1445 A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion
Mann, J. P.; Duan, X.; Alvarez-Guaita, A.; Haider, A.; Luijten, I.; Page, M.; Patel, S.; Scurria, F.; Protasoni, M.; Tabara, L. C.; Virtue, S.; O'Rahilly, S. I.; Armstrong, M.; Prudent, J.; Semple, R. K.; Savage, D. B.
10.1101/2022.09.20.508662 — cell biology — Posted on 2022-09-22
1446 Myosin II regulatory light chain phosphorylation and formin availability modulate cytokinesis upon changes in carbohydrate metabolism.
Prieto-Ruiz, F.; Gomez-Gil, E.; Martin-Garcia, R.; Perez-Diaz, A. J.; Vicente-Soler, J.; Franco, A.; Soto, T.; Perez, P.; Madrid, M.; Cansado, J.
10.1101/2022.09.20.508671 — cell biology — Posted on 2022-09-22
1448 Bacillus subtilis remains translationally active after CRISPRi-mediated replication initiation arrest
Munoz-Gutierrez, V.; Cornejo, F. A.; Schmidt, K.; Frese, C. K.; Halte, M.; Erhardt, M.; Elsholz, A. K. W.; Turgay, K.; Charpentier, E.
10.1101/2022.09.20.508806 — microbiology — Posted on 2022-09-22
1449 Antimicrobial Susceptibility Profiles of Bacteria Isolated from The Ozama River in Santo Domingo, Dominican Republic
Bonnellly, R.; Cavalcante, A. L. Q.; del Rosario Zorrilla, C.; Calderon, V. V.; Duarte, A.; Barauna, R. A.; Juca Ramos, R. T.; Rodriguez, Y.; Rodriguez de Francisco, L. E.; Maroto, L. O.; Perdomo, O. P.; Franco, E. F.
10.1101/2022.09.19.508624 — microbiology — Posted on 2022-09-22
1451 FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis
Liu, C.; Schönke, M.; Spoorenberg, B.; Lambooij, J.; van der Zande, H.; Zhou, E.; Tushuizen, M. E.; Andreasson, A.-C.; Park, A.; Oldham, S.; Uhrbom, M.; Ahlstedt, I.; Ikeda, Y.; Wallenius, K.; Peng, X.-R.; Guigas, B.; Boon, M. R.; Wang, Y.; Rensen, P. C.
10.1101/2022.09.20.508654 — pathology — Posted on 2022-09-22
1452 Computer generation of fruit shapes from DNA sequence
Perez-Enciso, M.; Pons, C.; Granell, A.; Soler, S.; Pico, B.; Monforte, A.; Zingaretti, L. M.
10.1101/2022.09.19.508595 — bioinformatics — Posted on 2022-09-22
1453 Microtubule-mediated GLUT4 trafficking is disrupted in insulin resistant skeletal muscle
Knudsen, J. R.; Persson, K. W.; Henriquez-Olguin, C.; Li, Z.; Di Leo, N.; Raun, S. H.; Hingst, J. R.; Trouillon, R.; Wohlwend, M.; Wojtaszewski, J. F. P.; Gijs, M. A. M.; Jensen, T.
10.1101/2022.09.19.508621 — cell biology — Posted on 2022-09-22
1454 Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches
Lo, E. K. K.; Wang, x.; Lee, P.-K.; Wong, H.-C.; Lee, J. C.-Y.; Gallego, C. G.; Zhao, D.; El-Nezami, H.; Li, J.
10.1101/2022.09.21.508814 — cancer biology — Posted on 2022-09-21
1455 RNASeq as a tool to understand dysregulation of potential biomarkers in HNSC
Ezhuthachan, M. M.; Joshi, M.; Raval, I.; Joshi, C.; Dasgupta, A.; Majumdar, S.; A Shah, S.
10.1101/2022.09.20.508683 — cancer biology — Posted on 2022-09-21
1458 Nanoparticle-mediated Targeting of the Fusion Gene RUNX1/ETO in t(8;21)-positive Acute Myeloid Leukaemia
Issa, H.; Swart, L.; Rasouli, M.; Ashtiani, M.; Nakjang, S.; jyotsana, n.; Schuschel, K.; Heuser, M.; Blair, H.; Heidenreich, O.
10.1101/2022.09.21.508893 — cancer biology — Posted on 2022-09-21
1459 Transcriptional immunogenomic analysis reveals distinct immunological clusters in pediatric nervous system tumours
Nabbi, A.; Beck, P.; Delaidelli, A.; Oldridge, D. A.; Sudhaman, S.; Zhu, K.; Yang, S. Y. C.; Mulder, D. T.; Bruce, J. P.; Paulson, J. N.; Raman, P.; Zhu, Y.; Resnick, A. C.; Sorensen, P. H.; Sill, M.; Brabetz, S.; Lambo, S.; Malkin, D.; Johann, P. D.; Kool, M.; Jones, D. T. W.; Pfister, S. M.; Jäger, N.; Pugh, T. J.
10.1101/2022.09.20.508719 — genomics — Posted on 2022-09-21
1461 Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2
Rudraraju, R.; Gartner, M. J.; Neil, J. A.; Stout, E. S.; Chen, J.; Needham, E. J.; See, M.; Mackenzie-Kludas, C.; Yang, L. Y.; Wang, M.; Pointer, H.; Karavendzas, K.; Abu-Bonsrah, D.; Drew, D.; Sun, Y. B. Y.; Tan, J. P.; Sun, G.; Salavaty, A.; Charitakis, N.; Nim, H. T.; Currie, P. D.; Tham, W.-H.; Porrello, E.; Polo, J.; Humphrey, S. J.; Ramialison, M.; Elliott, D. A.; Subbarao, K.
10.1101/2022.09.20.508614 — microbiology — Posted on 2022-09-21
1462 Cell wall carbohydrate dynamics during the differentiation of infection structures by the apple scab fungus, Venturia inaequalis
Rocafort, M.; Srivastava, V.; Bowen, J. K.; Diaz-Moreno, S. M.; Bulone, V.; Plummer, K. M.; Sutherland, P. W.; Anderson, M. A.; Bradshaw, R. E.; Mesarich, C. H.
10.1101/2022.09.21.508768 — microbiology — Posted on 2022-09-21
1463 Exposure to BA.4/BA.5 Spike glycoprotein drives pan-Omicron neutralization in vaccine-experienced humans and mice
Muik, A.; Lui, B. G.; Bacher, M.; Wallisch, A.-K.; Toker, A.; Couto, C. I. C.; Gueler, A.; Mampilli, V.; Schmitt, G. J.; Mottl, J.; Ziegenhals, T.; Fesser, S.; Reinholz, J.; Wernig, F.; Schraut, K.-G.; Hefesha, H.; Cai, H.; Yang, Q.; Walzer, K. C.; Grosser, J.; Strauss, S.; Finlayson, A.; Krueger, K.; Ozhelvaci, O.; Grikscheit, K.; Kohmer, N.; Ciesek, S.; Swanson, K. A.; Vogel, A. B.; Tuereci, O.; Sahin, U.
10.1101/2022.09.21.508818 — immunology — Posted on 2022-09-21
1465 ETV6 Deficiency and Microsatellite Enhancers Drive Transcriptional Dysregulation in B-Lymphoblastic Leukemia
Kodgule, R.; Goldman, J. W.; Monovich, A. C.; Saari, T.; Hall, C. N.; Rajesh, N.; Gupta, J.; Aguilar, A. R.; Brown, N. A.; Chiang, M. Y.; Cieslik, M. P.; Ryan, R. J. H.
10.1101/2022.09.20.508499 — cancer biology — Posted on 2022-09-21
1471 SRSF2 is required for mRNA splicing and spermatogenesis
Sun, Q.; Lei, W.-L.; Du, Z.; Meng, T.-G.; SU, R.; Li, Y.-Y.; Liu, W.; Sun, S.; Liu, M.-Y.; Hou, Y.; Zhang, C.-H.; yaoting, G.; Schatten, H.; Han, Z.; Liu, C.; Wang, Z.-B.; Qian, W.-P.
10.1101/2022.09.20.508723 — developmental biology — Posted on 2022-09-21
1472 Bub1 kinase acts as a signalling hub for the entire Cryptococcus neoformans spindle assembly checkpoint pathway
Leontiou, I.; Davies, T.; Clark, I.; Aktar, K.; Suresh, A. P.; Abad, M. A.; Spanos, C.; Lee, K.-T.; Bahn, Y.-S.; Jeyaprakash, A. A.; Hardwick, K. G.
10.1101/2022.09.21.508923 — cell biology — Posted on 2022-09-21
1473 Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression
Malireddi, R. K. S.; Bynigeri, R.; Kancharana, B.; Sharma, B. R.; Burton, A. R.; Pelletier, S.; Kanneganti, T.-D.
10.1101/2022.09.21.508892 — cell biology — Posted on 2022-09-21
1474 Comparative virome analysis of individual shedding routes of Miniopterus fuliginosus bats inhabiting the Wavul Galge Cave, Sri Lanka
Muzeniek, T.; Perera, T.; Siriwardana, S.; Bas, D.; Bayram, F.; Oeruc, M.; Becker-Ziaja, B.; Perera, I.; Weerasena, J.; Handunnetti, S.; Schwarz, F.; Premawansa, G.; Premawansa, S.; Yapa, W.; Nitsche, A.; Kohl, C.
10.1101/2022.09.21.508883 — molecular biology — Posted on 2022-09-21
1479 Characterization of Plasmodium falciparum RAP domain proteins-RAP291 and RAP070, and their association with ribosomal RNAs
Akhtar, A.; Deshmukh, A.; Panda, A.; Saini, E.; Pandey, R.; Junaid, I. T.; Onchieku, N.; Parveen, S.; Singh, S. S.; Gupta, D.; Theisen, M.; Mohmmed, A.; Malhotra, P.
10.1101/2022.09.21.508831 — microbiology — Posted on 2022-09-21
1480 Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA
Kwun, M. J.; Ion, A. V.; Cheng, H.-C.; D'Aeth, J. C.; Dougan, S.; Oggioni, M. R.; Goulding, D. A.; Bentley, S. D.; Croucher, N. J.
10.1101/2022.09.21.508813 — microbiology — Posted on 2022-09-21
1482 Cellular and molecular dynamics in the lungs of neonatal and juvenile mice in response to E. coli
McGrath-Morrow, S. A.; Venezia, J.; Ndeh, R.; Singer, B. D.; Cimbro, R.; Soloski, M.; Scott, A. L.
10.1101/2022.09.21.508849 — immunology — Posted on 2022-09-21
1483 Transcription coactivator OCA-B/Pou2af1 is necessary and sufficient to promote T cell-intrinsic CD4 memory
Sun, W.; Kim, H.; Perovanovic, J.; Hughes, E.; Du, J.; Ibarra, A.; Hale, J. S.; Williams, M. A.; Tantin, D.
10.1101/2022.09.21.508912 — immunology — Posted on 2022-09-21
1484 A hierarchy of cell death pathways confers layered resistance to shigellosis in mice
Roncaioli, J. L.; Babirye, J. P.; Chavez, R. A.; Liu, F. L.; Turcotte, E. A.; Lee, A. Y.; Lesser, C. F.; Vance, R. E.
10.1101/2022.09.21.508939 — immunology — Posted on 2022-09-21
1489 Metabolic acids impact bone mineral maturation
Li, Y.; Li, R.; Reid, D. G.; Lunn, J. T.; Muller, K. H.; Laurencin, D.; Bonhomme, C.; Ossa, E. A.; Sommerdijk, N. A. J. M.; Duer, M.
10.1101/2022.09.21.508894 — biophysics — Posted on 2022-09-21
1492 Global phylogenomic assessment of Leptoseris and Agaricia reveals substantial undescribed diversity at mesophotic depths
Gijsbers, J. C.; Englebert, N.; Prata, K. E.; Pichon, M.; Dinesen, Z.; Brunner, R.; Eyal, G.; Gonzalez-Zapata, F. L.; Kahng, S. E.; Latijnhouwers, K. R.; Muir, P.; Radice, V. Z.; Sanchez, J. A.; Vermeij, M. J.; Hoegh-Guldberg, O.; Jacobs, S. J.; Bongaerts, P.
10.1101/2022.09.12.504660 — evolutionary biology — Posted on 2022-09-21
1493 Three-dimensional chromatin re-organization during muscle stem cell aging
Yang, B. A.; Larouche, J. A.; Sabin, K. M.; Fraczek, P. M.; Parker, S. C. J.; Aguilar, C. A.
10.1101/2022.09.21.508601 — cell biology — Posted on 2022-09-21
1494 Cryo-plasma FIB/SEM volume imaging of biological specimens
Dumoux, M.; Glen, T.; Ho, E. M. L.; Perdigao, L. M. A.; Klumpe, S.; Yee, N. B. Y.; Farmer, D.; Smith, J. L. R.; Lai, P. Y. A.; Bowles, W.; Kelley, R.; Plitzko, J. M.; Wu, L.; Basham, M.; Clare, D. K.; Siebert, C. A.; Darrow, M. C.; Naismith, J. H.; Grange, M.
10.1101/2022.09.21.508877 — cell biology — Posted on 2022-09-21
1495 Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II
Rengachari, S.; Schilbach, S.; Kaliyappan, T.; Gouge, J.; Zumer, K.; Schwarz, J.; Urlaub, H.; Dienemann, C.; Vannini, A.; Cramer, P.
10.1101/2022.09.21.508861 — molecular biology — Posted on 2022-09-21
1496 Emergence of plasmid-mediated RND-type efflux pump gene cluster tmexCD-toprJ in Shewanella xiamenensis in a water environment
Dao, T. D.; Takemura, T.; Kasuga, I.; Hirabayashi, A.; Nga, N. T.; Anh, P. H. Q.; Tu, N. D.; Trang, L. T.; Tran, H. H.; Shibayama, K.; Hasebe, F.; Suzuki, M.
10.1101/2022.09.15.508154 — microbiology — Posted on 2022-09-21
1497 Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection
Martin, G.; Torres, J. L.; Pholcharee, T.; Oyen, D.; Flores-Garcia, Y.; Gibson, G.; Moskovitz, R.; Beutler, N.; Jung, D. D.; Copps, J.; Lee, W.-H.; Gonzalez-Paez, G.; Emerling, D.; MacGill, R. S.; Locke, E.; King, C. R.; Zavala, F.; Wilson, I. A.; Ward, A.
10.1101/2022.09.20.508747 — immunology — Posted on 2022-09-21
1498 Nav1.1 is essential for proprioceptive signaling and motor behaviors
Espino, C. M.; Lewis, C. M.; Ortiz, S.; Dalal, M. S.; Garlapalli, S.; Wells, K. M.; O'Neil, D. A.; Wilkinson, K. A.; Griffith, T. N.
10.1101/2022.05.05.490851 — neuroscience — Posted on 2022-09-21
1499 Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer's Disease
Bubak, A. N.; Merle, L.; Niemeyer, C. S.; Baxter, D. B.; Polese, A. G.; Ramakrishnan, V.; Gomez, J.; Madrigal, L.; Villegas-Lanau, A.; Lopera, F.; Macklin, W.; Frietze, S.; Nagel, M. A.; Restrepo, D.
10.1101/2022.07.19.500641 — neuroscience — Posted on 2022-09-21
1502 Membrane contact site detection (MCS-DETECT) reveals dual control of rough mitochondria-ER contacts
Cardoen, B.; Vandevoorde, K. R.; GAO, G.; Alan, P.; Liu, W.; Tiliakou, E.; Vogl, A. W.; Hamarneh, G.; Nabi, I. R.
10.1101/2022.06.23.497346 — cell biology — Posted on 2022-09-21
1504 Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death
Lilja, J.; Kaivola, J.; Conway, J. R. W.; Vuorio, J.; Parkkola, H.; Roivas, P.; Varila, T.; Jacquemet, G.; Peuhu, E.; Wang, E.; Pentikäinen, U.; Posada, I. M. D.; Hamidi, H.; Najumudeen, A. K.; Sansom, O. J.; Barsukov, I. L.; Abankwa, D.; Vattulainen, I.; Salmi, M.; Ivaska, J.
10.1101/2022.09.21.508660 — cancer biology — Posted on 2022-09-21
1505 Loss of the first β-strand of human prion protein generates an aggregation-competent partially "open" form
Hosszu, L. L. P.; Sangar, D.; Batchelor, M.; Risse, E.; Hounslow, A. M.; Waltho, J. P.; Collinge, J.; Bieschke, J.
10.1101/2022.09.20.508729 — biophysics — Posted on 2022-09-21
1506 Millisecond cryo-trapping by the spitrobot crystal plunger simplifies time-resolved crystallography
Mehrabi, P.; Sung, S.; von Stetten, D.; Prester, A.; Hatton, C. E.; Kleine-Doepke, S.; Berkes, A.; Gore, G.; Leimkohl, J.-P.; Schikora, H.; Kollewe, M.; Rohde, H.; Wilmanns, M.; Tellkamp, F.; Schulz, E. C.
10.1101/2022.09.20.508674 — biophysics — Posted on 2022-09-21
1507 Sequential Activation and Local Unfolding Control Poly(A)-Binding Protein Condensation
Chen, R.; Kahan, D.; Shangguan, J.; Sachleben, J. R.; Riback, J. A.; Drummond, D. A.; Sosnick, T.
10.1101/2022.09.21.508844 — biophysics — Posted on 2022-09-21
1508 LEAP2 is a more conserved ligand than ghrelin for fish GHSRs
Li, H.-Z.; Shao, X.-X.; Wang, Y.-F.; Liu, Y.-L.; Xu, Z.-G.; Guo, Z.-Y.
10.1101/2022.09.21.508860 — biochemistry — Posted on 2022-09-21
1509 Structural studies of cilia and flagella associated protein 410 (CFAP410) reveal its bimodular organization with an N-terminal LRR motif and a C-terminal tetrameric helical bundle
Stadler, A.; Gabriel, H. B.; Alonso-Gil, S.; Deng, X.; Crickley, R.; Korbula, K.; Huang, K.; Zagrovic, B.; Vaughan, S.; Sunter, J.; Dong, G.
10.1101/2022.09.21.508879 — biochemistry — Posted on 2022-09-21
1511 Mitochondrial protein import clogging as a mechanism of disease
Coyne, L. P.; Wang, X.; Song, J.; de Jong, E.; Schneider, K.; Massa, P. T.; Middleton, F. A.; Becker, T.; Chen, X. J.
10.1101/2022.09.20.508789 — biochemistry — Posted on 2022-09-21
1512 Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
Nguyen, A.; Lugarini, F.; David, C.; Hosani, P.; Knotkova, B.; Patel, A.; Parfentev, I.; Friedrich, A.; Urlaub, H.; Meinecke, M.; Stork, B.; Faesen, A.
10.1101/2022.09.21.508836 — biochemistry — Posted on 2022-09-21
1513 Autoinsertion (LAiR): rapid functional reconstitution of integral membrane proteins into lipid bilayers
Godoy-Hernandez, A.; Asseri, A. H.; Purugganan, A. J.; Jiko, C.; de Ram, C.; Lill, H.; Pabst, M.; Mitsuoka, K.; Gerle, C.; Bald, D.; McMillan, D. G. G.
10.1101/2022.09.21.508839 — biochemistry — Posted on 2022-09-21
1515 Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis
Yao, Z.; Qi, W.; Liu, L.; Shao, Y.; Zhang, H.; Yin, J.; Pan, H.; Guo, X.; Liu, A.; Cai, D.; Bai, X.; Zhang, H.
10.1101/2022.09.20.508661 — immunology — Posted on 2022-09-21
1516 Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans
Ridley, A. J.; Ou, Y.; Karlsson, R.; Pun, N.; Birchenough, H. L.; Jowitt, T. A.; Lawless, C.; Miller, R. L.; Dyer, D. P.
10.1101/2022.09.20.508420 — immunology — Posted on 2022-09-21
1517 Synaptic scale dopamine disruption in Huntington's Disease model mice imaged with near infrared catecholamine nanosensors
Yang, S. J.; Del Bonis-O'Donnell, J. T.; Giordani, F. A.; Wang, J. W.-T.; Lui, A.; Piekarski, D.; Irrinki, A.; Schaffer, D.; Landry, M. P.
10.1101/2022.09.19.508617 — neuroscience — Posted on 2022-09-21
1521 Single-cell analysis of megakaryopoiesis in peripheral CD34+ cells: insights into ETV6-related thrombocytopenia
Bigot, T. J.-R.; Gabinaud, E.; Hannouche, L.; Sbarra, V.; Andersen, E.; Bastelica, D.; Falaise, C.; Ibrahim-Kosta, M.; Loosveld, M.; Saultier, P.; Payet-Bornet, D.; Alessi, M.-C.; Potier, D.; Poggi, M.
10.1101/2022.09.20.508634 — bioinformatics — Posted on 2022-09-21
1524 Regionally enriched rare deleterious exonic variants in the UK and Ireland
Halachev, M.; Gountouna, E.; Meynert, A.; Regeneron Genetics Center, ; Tzoneva, G.; Shuldiner, A. R.; Semple, C. A.; Wilson, J. F.
10.1101/2022.09.19.508526 — genetics — Posted on 2022-09-21
1526 DEED: A Dataset for Dream-related Emotion Research
Liu, W.; Zhang, Y.; Ma, P.; Zheng, L.; Zhou, D.; Chen, Z.; Shen, M.; Cai, Y.; Lu, Z.; Liu, Q.; Luo, J.; Wang, X.
10.1101/2022.09.19.508475 — neuroscience — Posted on 2022-09-21
1527 Posterior white matter hyperintensities are associated with reduced medial temporal lobe subregional integrity and long-term memory in older adults
Rizvi, B.; Sathishkumar, M.; Kim, S.; Marquez, F.; Granger, S. J.; Larson, M. S.; Miranda, B. A.; Hollearn, M. K.; McMillan, L.; Nan, B.; Tustison, N. J.; Lao, P. J.; Brickman, A. M.; Greenia, D.; Corrada, M. M.; Kawas, C. H.; Yassa, M. A.
10.1101/2022.09.19.508591 — neuroscience — Posted on 2022-09-21
1529 Systematic analysis uncovers SYK dependency in NF1LoF melanoma cells
Abecunas, C.; Whitehead, C.; Ziemke, E.; Baumann, D. G.; Frankowski-McGregor, C.; Sebolt-Leopold, J.; Fallahi-Sichani, M.
10.1101/2022.03.06.483170 — cancer biology — Posted on 2022-09-21
1535 Differential elasticity in lineage segregation of embryonic stem cells
Ritter, C.; Lejnse, N.; Farhangi Barooji, Y.; Brickman, J. M.; Doostmohammadi, A.; Oddershede, L. B.
10.1101/2022.09.21.508812 — biophysics — Posted on 2022-09-21
1537 Amphibian larvae benefit from a warm environment under simultaneous threat from chytridiomycosis and ranavirosis
Herczeg, D.; Holly, D.; Kasler, A.; Bokony, V.; Papp, T.; Takacs-Vago, H.; Ujszegi, J.; Hettyey, A.
10.1101/2022.09.20.508725 — evolutionary biology — Posted on 2022-09-21
1538 Asymmetrical gene flow between coastal and inland dunes in a threatened digger wasp
Batsleer, F.; Gallin, M.; Delafonteyne, M.; Dekeukeleire, D.; T'Jollyn, F.; Vantieghem, P.; Vanden Broeck, A.; Mergeay, J.; Maes, D.; Bonte, D.
10.1101/2022.09.20.508247 — ecology — Posted on 2022-09-21
1539 Genome characterization of monkeypox cases detected in India: Identification of three sub clusters among A.2 lineage
Shete, A. M.; Yadav, P. D.; Kumar, A.; Patil, S.; Patil, D. Y.; Joshi, Y.; Majumdar, T.; Relhan, V.; Sahay, R. R.; Vasu, M.; Gawande, P.; Verma, A.; Kumar, A.; Dhakad, S.; Krishnan, A. B.; Chenayil, S.; Kumar, S.; Abraham, P.
10.1101/2022.09.16.507742 — microbiology — Posted on 2022-09-21
1540 Allosteric regulation of switch-II controls K-Ras oncogenicity
Yang, M. H.; Tran, T. H.; Hunt, B.; Agnor, R.; Johnson, C. W.; Waybright, T. J.; Nowak, J. A.; Stephen, A. G.; Simanshu, D. K.; Haigis, K. M.
10.1101/2022.09.20.508702 — cancer biology — Posted on 2022-09-21
1541 Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
Faysal, K. M. R.; Renner, N.; Marquez, C. L.; Shah, V.; Tuckwell, A. J.; Christie, M. P.; Parker, M. W.; Turville, S. G.; James, L.; Towers, G. J.; Jacques, D. A.; Boecking, T.
10.1101/2022.09.21.508807 — biophysics — Posted on 2022-09-21
1545 MR1 dependent MAIT cell activation is regulated by autophagy associated proteins
Phalora, P.; Ussher, J. E.; Hester, S.; Marchi, E.; Mak, J. Y. W.; Fairlie, D. P.; Klenerman, P.
10.1101/2022.09.20.508788 — cell biology — Posted on 2022-09-21
1547 Exercise induces myonuclear remodelling in humans independently of age
Battey, E.; Ross, J. A.; Hoang, A.; Wilson, D. G. S.; Levy, Y.; Pollock, R. D.; Kalakoutis, M.; Pugh, J. N.; Close, G. L.; Ellison-Hughes, G. M.; Lazarus, N.; Harridge, S. D. R.; Iskratsch, T.; Ochala, J.; Stroud, M.
10.1101/2022.09.20.506578 — cell biology — Posted on 2022-09-21
1548 Peroxisome biogenesis initiated by protein phase separation
Ravindran, R.; Bacellar, I. O. L.; Castellanos-Girouard, X.; Zhang, Z.; Kisley, L.; Michnick, S. W.
10.1101/2022.09.20.508718 — cell biology — Posted on 2022-09-21
1549 Direct control of translational elongation by TAOK2β highlights altered protein synthesis as a fundamental underlying component of autism
Henis, M.; Rucker, T.; Scharrenberg, R.; Richter, M.; Baltussen, L.; Meka, D. P.; Schwanke, B.; Neelagandan, N.; Daaboul, D.; Murtaza, N.; Krisp, C.; Harder, S.; Schluter, H.; Kneussel, M.; Hermans-Borgmeyer, I.; de Wit, J.; Singh, K. K.; Duncan, K. E.; de Anda, F. C.
10.1101/2022.08.22.504812 — neuroscience — Posted on 2022-09-21
1550 On predicting heterogeneity in nanoparticle dosage
Dowling, C. V.; Cevaal, P. M.; Faria, M.; Johnston, S. T.
10.1101/2022.05.26.493665 — biophysics — Posted on 2022-09-21
1553 An Open Microfluidic Coculture Model of Fibroblasts and Eosinophils to Investigate Mechanisms of Airway Inflammation
Zeng, Y.; Su, X.; Takezawa, M. G.; Fichtinger, P. S.; Lee, U. N.; Pippin, J. W.; Shankland, S. J.; Lim, F. Y.; Denlinger, L. C.; Jarjour, N. N.; Mathur, S. K.; Sandbo, N.; Berthier, E.; Esnault, S.; Bernau, K.; Theberge, A. B.
10.1101/2022.07.11.499658 — cell biology — Posted on 2022-09-21
1555 Extraordinary selection on the human X chromosome associated with archaic admixture
Skov, L.; Coll Macia, M.; Lucotte, E.; Cavassim, M. I. A.; Castellano, D.; Schierup, M.; Munch, K.
10.1101/2022.09.19.508556 — evolutionary biology — Posted on 2022-09-20
1556 A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation
Knudsen, T. E.; Hamilton, W.; Proks, M.; Lykkegaard, M.; Nielsen, A. V.; Trusina, A.; Brickman, J. M.
10.1101/2022.09.20.508291 — cell biology — Posted on 2022-09-21
1557 A neural mechanism of cognitive reserve: The case of bilingualism
Stevens, W. D.; Khan, N.; Anderson, J. A. E.; Grady, C. L.; Bialystok, E.
10.1101/2022.09.20.508678 — neuroscience — Posted on 2022-09-20
1558 Striatal dopamine integrates cost, benefit and motivation
Eshel, N.; Touponse, G. C.; Wang, A. R.; Osterman, A. K.; Shank, A. N.; Groome, A. M.; Taniguchi, L.; Pinto, D. F. C.; Tucciarone, J.; Bentzley, B. S.; Malenka, R. C.
10.1101/2022.09.20.508777 — neuroscience — Posted on 2022-09-20
1560 DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network
Carraro, M.; Hendriks, I. A.; Hammond, C. M.; Solis, V.; Volker-Albert, M.; Elsborg, J. D.; Weisser, M. B.; Spanos, C.; Montoya, G.; Rappsilber, J.; Imhof, A.; Nielsen, M. L.; Groth, A.
10.1101/2022.09.20.508668 — molecular biology — Posted on 2022-09-20
1563 A small molecule RIG-I agonist serves to adjuvant broad multifaceted influenza virus vaccine immunity
Hemann, E. A.; Knoll, M. L.; Wilkins, C. R.; Subra, C.; Green, R.; Garcia-Sastre, A.; Thomas, P.; Trautmann, L.; Ireton, R.; Loo, Y.-M.; Gale, M.
10.1101/2022.09.20.508779 — immunology — Posted on 2022-09-20
1566 Dynamic Kinetic Models Capture Cell-Free Metabolism for Improved Butanol Production
Martin, J. P.; Rasor, B. J.; DeBonis, J.; Karim, A. S.; Jewett, M. C.; Tyo, K. E. J.; Broadbelt, L. J.
10.1101/2022.09.20.508127 — synthetic biology — Posted on 2022-09-20
1567 A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells
Heacock, M. L.; Abdulaziz, E. N.; Pan, X.; Zuckerman, A. L.; Violante, S.; Yao, C.; Cross, J. R.; Cracan, V.
10.1101/2022.09.20.508785 — bioengineering — Posted on 2022-09-20
1568 SLX4 assembles nuclear condensates that compartmentalize the SUMO-RNF4 pathway and drive DNA repair.
Alghoul, E.; Paloni, M.; Takedachi, A.; Urbach, S.; Barducci, A.; Gaillard, P.-H. L.; Basbous, J.; Constantinou, A.
10.1101/2022.09.20.508711 — biochemistry — Posted on 2022-09-20
1570 Population level genetic memory of prior metabolic adaptation in E. coli
Katz, S.; Grajeda-Iglesias, C.; Agranovic, B.; Ghrayeb, A.; Abramovich, I.; Hilau, S.; Gottlieb, E.; Hershberg, R.
10.1101/2022.09.20.508651 — evolutionary biology — Posted on 2022-09-20
1574 Small molecule inhibition of multiple RNA binding proteins underlies Musashi-2 independent phenotypes
Walters, K.; Sajek, M. P.; Issaian, A.; Baldwin, A.; Harrison, E.; Murphy, E.; Daniels, M.; Haines, J.; Hansen, K.; D'Alessandro, A.; Mukherjee, N.
10.1101/2022.09.20.508735 — molecular biology — Posted on 2022-09-20
1575 Regulation of cellular LDL uptake by PROX1 and CHD7
Serrano Zayas, C.; Holding, M. L.; Khan, T. G.; Tang, V. T.; Skidmore, J. M.; Martin, D. M.; Ginsburg, D.; Emmer, B. T.
10.1101/2022.09.20.507601 — molecular biology — Posted on 2022-09-20
1576 CDKL5 regulates p62-mediated selective autophagy and host antiviral defense
Thinwa, J. W.; Zou, Z.; Parks, E.; Sebti, S.; Hui, K.; Singh, V.; Wei, Y.; Urquhart, G.; Jewell, J. L.; Pfeiffer, J. K.; Levine, B.; Reese, T. A.; Shiloh, M. U.
10.1101/2022.09.20.508746 — microbiology — Posted on 2022-09-20
1577 Zika virus spreads through infection of lymph node-resident macrophages
Hickman, H.; Reynoso, G. V.; Gordon, D. N.; Kalia, A.; Aguilar, C. C.; Malo, C.; Aleshnick, M.; Dowd, K.; Cherry, C.; Shannon, J.; Vrba, S.; Maciejewski, S.; Asano, K.; Pierson, T.
10.1101/2022.09.20.508424 — microbiology — Posted on 2022-09-20
1579 Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation
Linares, R.; Arnaud, C.-A.; Effantin, G.; Darnault, C.; Epalle, N. H.; Boeri Erba, E.; Schoehn, G.; Breyton, C.
10.1101/2022.09.20.507954 — microbiology — Posted on 2022-09-20
1580 Fake it to break it: mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito Aedes aegypti
Reitmayer, C. M.; Levitt, E.; Basu, S.; Atkinson, B.; Fragkoudis, R.; Merits, A.; Lumley, S.; Larner, W.; Diaz, A. V.; Rooney, S.; Thomas, C. J. E.; von Wyschetzki, K.; Rausalu, K.; Alphey, L.
10.1101/2022.09.20.508686 — microbiology — Posted on 2022-09-20
1582 origamiFISH allows universal, label-free, single molecule visualization of DNA origami nanodevices across biological samples
Wang, W. X.; Douglas, T. R.; Zhang, H.; Bhattacharya, A.; Rothenbroker, M.; Jia, Z.; Muffat, J.; Li, Y.; Chou, L. Y. T.
10.1101/2022.09.19.508533 — synthetic biology — Posted on 2022-09-20
1583 Golden Standard: A complete standard, portable, and interoperative MoClo tool for model and non-model bacterial hosts.
Blazquez, B.; Torres-Bacete, J.; San Leon, D.; Kniewel, R.; Martinez, I.; Sordon, S.; Wilczak, A.; Salgado, S.; Huszcza, E.; Popłonski, J.; Prieto, M. A.; Nogales, J.
10.1101/2022.09.20.508659 — synthetic biology — Posted on 2022-09-20
1592 A benchmarking of human Y-chromosomal haplogroup classifiers from whole-genome and whole-exome sequence data
Garcia-Olivares, V.; Munoz-Barrera, A.; Rubio Rodriguez, L. A.; Jaspez, D.; Diaz de-Usera, A.; Inigo Campos, A.; Veeramah, K. R.; Alonso, S.; Thomas, M. G.; Gonzalez-Montelongo, R.; Lorenzo-Salazar, J. M.; Flores, C.
10.1101/2022.09.19.508481 — genomics — Posted on 2022-09-20
1593 TLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair
Ghosh, I.; Kwon, Y.; Badamchi Shabestari, A.; Chikhale, R.; Chen, J.; Wiese, C.; Sung, P.; DeBenedetti, A.
10.1101/2022.09.19.508551 — molecular biology — Posted on 2022-09-20
1594 Molecular features underlying Pseudomonas aeruginosa persistence in human plasma
Janet-Maitre, M.; Pont, S.; Masson, F.; Sleiman, S.; Trouillon, J.; Robert-Genthon, M.; Gallet, B.; Dumestre-Perard, C.; Elsen, S.; Moriscot, C.; Bardoel, B.; Rooijakkers, S.; Cretin, F.; Attree, I.
10.1101/2021.12.21.473675 — microbiology — Posted on 2022-09-20
1595 Host genetic background is a barrier to vaccine-induced protection against infection
Lai, R.; Gong, D.; Williams, T.; Ogunsola, A. F.; Cavallo, K.; Arlehamn, C. L.; Beamer, G.; Ferris, M.; Sassetti, C. M.; Lauffenburger, D.; Behar, S.
10.1101/2022.09.19.508548 — immunology — Posted on 2022-09-20
1600 Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals
Kliesmete, Z.; Wange, L. E.; Vieth, B.; Esgleas, M.; Radmer, J.; Huelsmann, M.; Geuder, J.; Richter, D.; Ohnuki, M.; Goetz, M.; Hellmann, I.; Enard, W.
10.1101/2021.02.05.429919 — evolutionary biology — Posted on 2022-09-20
1607 Foldseek: fast and accurate protein structure search
van Kempen, M.; Kim, S.; Tumescheit, C.; Mirdita, M.; Gilchrist, C. L. M.; Soeding, J.; Steinegger, M.
10.1101/2022.02.07.479398 — bioinformatics — Posted on 2022-09-20
1610 Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function
Carter, E. P.; Yoneten, K. K.; Gavara, N.; Tyler, E. J.; Gauthier, V.; Murray, E.; Cameron, A.; Pearce, O. M. T.; Grose, R. P.
10.1101/2022.09.20.508645 — cancer biology — Posted on 2022-09-20
1612 High transposase abundance in the deep ocean is linked to a particle-associated lifestyle
Zhong, J.; Kyrysyuk, O.; del Rosario Herhandez, T.; Tully, B. J.; Anderson, R. E.
10.1101/2022.04.27.489810 — bioinformatics — Posted on 2022-09-20
1615 Genomic variation across a clinical Cryptococcus population linked to disease outcome
Sephton-Clark, P. C. S.; Tenor, J.; Toffaletti, D.; Meyers, N.; Giamberardino, C.; Molloy, S.; Palmucci, J. R.; Chan, A.; Chikaonda, T.; Heyderman, R.; Hosseinipour, M.; Kalata, N.; Kanyama, C.; Kukacha, C.; Lupiya, D.; Mwandumba, H.; Harrison, T.; Bicanic, T.; Perfect, J. R.; Cuomo, C. A.
10.1101/2021.11.22.469645 — genomics — Posted on 2022-09-20
1617 Caste- and sex-specific DNA methylation in a bumblebee is associated with codon degeneracy.
Marshall, H.; Nicholas, M. T.; van Zweden, J. S.; Wäckers, F.; Ross, L.; Wenseleers, T.; Mallon, E. B.
10.1101/2021.12.17.473163 — evolutionary biology — Posted on 2022-09-20
1620 Barcode-free prediction of cell lineages from scRNA-seq datasets
Eisele, A. S.; Tarbier, M.; Dormann, A. A.; Pelechano, V.; Suter, D. M.
10.1101/2022.09.20.508646 — developmental biology — Posted on 2022-09-20
1621 mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells
Kubiura-Ichimaru, M.; Penfold, C.; Kojima, K.; Dollet, C.; Yabukami, H.; Semi, K.; Takashima, Y.; Boroviak, T.; Kawaji, H.; Woltjen, K.; Minoda, A.; Sasaki, E.; Watanabe, T.
10.1101/2022.09.20.508677 — developmental biology — Posted on 2022-09-20
1626 Loss of estrogen unleashing neuro-inflammation increases the risk of Alzheimer's disease in women
Li, F.; Oh, I.; Kumar, S.; Eteleeb, A.; Gupta, A.; Buchser, W.; Xiong, C.; Cole, S. F.; McDade, E.; Karch, C.; Harari, O.; Payne, P. R.; Cruchaga, C.
10.1101/2022.09.19.508592 — neuroscience — Posted on 2022-09-20
1627 A multiplex platform to identify mechanisms and modulators of proteotoxicity in neurodegeneration
Resnick, S. J.; Qamar, S. S.; Sheng, J.; Huang, L. H.; Nixon-Abell, J.; Melore, S.; Chung, C. W.; Li, X.; Wang, J.; Zhang, N.; Shneider, N. A.; Kaminski, C. F.; Ruggeri, F. S.; Schierle, G. S. K.; St George-Hyslop, P.; Chavez, A.
10.1101/2022.09.19.508444 — neuroscience — Posted on 2022-09-20
1628 Stroke disconnectome decodes reading networks
Forkel, S. J.; Labache, L.; Nachev, P.; Thiebaut de Schotten, M.; Hesling, I.
10.1101/2022.03.20.485029 — neuroscience — Posted on 2022-09-20
1629 Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands
Gao, Z.; Zheng, L.; Krieger-Redwood, K.; Halai, A.; Margulies, D. S.; Smallwood, J.; Jefferies, E.
10.1101/2022.05.14.491226 — neuroscience — Posted on 2022-09-20
1630 Sensory convergence and inhibitory divergence: deep dorsal horn inhibitory interneurons modulate the timing and magnitude of limb coordination during locomotion.
Ozeri-Engelhard, N.; Gradwell, M. A.; Laflamme, O. D.; Upadhyay, A.; Aoki, A.; Shrier, T.; Gandhi, M.; Gonzalez, M.; Eisdorfer, J. T.; Abbas- Zadeh, G.; Yusuf, N.; Imtiaz, Z.; Alomary, S. A.; Katz, J.; Haas, M.; Hernandez, Y.; Akay, T.; Abraira, V. E.
10.1101/2022.05.21.492933 — neuroscience — Posted on 2022-09-20
1636 Development of an Agrobacterium-delivered codon-optimized CRISPR/Cas9 system for chickpea genome editing
GUPTA, S. K.; Vishwakarma, N. K.; Malakar, P.; Vanspati, P.; Sharma, N. K.; Chattopadhyay, D.
10.1101/2022.09.20.508560 — plant biology — Posted on 2022-09-20
1638 Microneurography as a Minimally Invasive Method to Assess Target Engagement During Neuromodulation
Verma, N.; Knudsen, B.; Gholston, A.; Skubal, A.; Blanz, S.; Settell, M.; Frank, J.; Trevathan, J.; Ludwig, K.
10.1101/2022.08.19.504592 — bioengineering — Posted on 2022-09-20
1639 Tubulin engineering by semisynthesis reveals that polyglutamylation directs detyrosination
Ebberink, E.; Fernandes, S.; Hatzopoulos, G.; Agashe, N.; Guidotti, N.; Reichart, T. M.; Reymond, L.; Velluz, M. C.; Pourroy, C.; Janke, C.; Gonczy, P.; Fierz, B.; Aumeier, C.
10.1101/2022.09.20.508649 — biochemistry — Posted on 2022-09-20
1640 Eliminating Genes for a Two Component System Increases PHB Productivity in Cupriavidus basilensis 4G11 Under PHB Suppressing, Non-Stress Conditions
Sander, K. B.; Abel, A. J.; Friedline, S.; Sharpless, W.; Skerker, J. M. B.; Deutschbauer, A.; Clark, D. S.; Arkin, A. P.
10.1101/2022.09.19.508597 — genomics — Posted on 2022-09-20
1641 Survey of activation-induced genome architecture reveals a novel enhancer of Myc
Chan, W. F.; Coughlan, H. D.; Ruhle, M.; Iannarella, N.; Alvarado, C.; Groom, J. R.; Keenan, C. R.; Kueh, A. J.; Wheatley, A. K.; Smyth, G.; Allan, R. S.; Johanson, T. M.
10.1101/2022.09.14.508046 — genetics — Posted on 2022-09-20
1642 Comparison of Mitogenomic and Mitochondrial Markers for the Phylogenetic and Evolutionary Study of Marmosets, with special focus on captive Callithrix jacchus
Fonseca, J. L.; del Rosario, R. C. H.; de Oliveira, M. A. B.; Feng, G.; Igayara, C. S.; McCarroll, S. A.; Nicola, P. A.; Pereira, L. C. M.; Rogers, J.; Roos, C.; Malukiewicz, J.
10.1101/2022.09.19.508604 — genetics — Posted on 2022-09-20
1644 Dispersal provides trophic-level dependent insurance against a heatwave in freshwater ecosystems
Vad, C. F.; Hanny-Endredi, A.; Kratina, P.; Abonyi, A.; Mironova, E.; Murray, D. S.; Samchyshyna, L.; Tsakalakis, I.; Smeti, E.; Spatharis, S.; Tan, H.; Preiler, C.; Petrusek, A.; Bengtsson, M. M.; Ptacnik, R.
10.1101/2022.09.20.508571 — ecology — Posted on 2022-09-20
1646 The Long Noncoding RNA Playrr Regulates Pitx2 Dosage and Protects Against Cardiac Arrhythmias
Chen, F. L.; Oxford, E. M.; Chou, S.-P.; Li, N.; Leach, J. P.; Perry, S. K.; Sanketi, B. D.; Cong, C.; Kupiec-Weglinski, S. A.; Dubowitz, R.; Daugherity, E.; Martin, J. F.; Danko, C. G.; Kurpios, N. A.
10.1101/2022.09.20.508562 — developmental biology — Posted on 2022-09-20
1647 TLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair
Ghosh, I.; Kwon, Y.; Badamchi Shabestari, A.; Chikhale, R.; Chen, J.; Sung, P.; DeBenedetti, A.
10.1101/2022.09.19.508551 — molecular biology — Posted on 2022-09-20
1649 Detection of rifampicin resistance in sputum samples by PCR-ELISA
Caceres-Rey, O.; Bellido-Pantoja, R.; Pacheco-Ascencio, E.; Valencia-Torres, E.
10.1101/2022.09.19.508626 — molecular biology — Posted on 2022-09-20
1650 The Clostridioides difficile S-Layer Protein A (SlpA) serves as a general phage receptor
Royer, A. L. M.; Umansky, A. A.; Allen, M.-M.; Garneau, J. R.; Bedoya, M. O.; Kirk, J. A.; Govoni, G.; Fagan, R. P.; Soutourina, O.; Fortier, L.-C.
10.1101/2022.09.19.508581 — microbiology — Posted on 2022-09-20
1653 Early Computational Detection of Potential High Risk SARS-CoV-2 Variants
Beguir, K.; Skwark, M. J.; Fu, Y.; Pierrot, T.; Lopez Carranza, S. N.; Laterre, A.; Kadri, I.; Korched, A.; Lowegard, A. U.; Lui, B. G.; Sanger, B.; Liu, Y.; Poran, A.; Muik, A.; Sahin, U.
10.1101/2021.12.24.474095 — bioinformatics — Posted on 2022-09-20
1656 Allosteric Regulation of Aptamer Affinity through Mechano-Chemical Coupling
Qu, H.; Zheng, M.; Ma, Q.; Wang, L.; Mao, Y.; Eisenstein, M.; Soh, H. T.; Zheng, L.
10.1101/2022.07.28.501929 — biochemistry — Posted on 2022-09-20
1658 APOE ε4 gene dose effect on imaging and blood biomarkers of glial reactivity and β-amyloid pathology
Snellman, A.; Ekblad, L. L.; Tuisku, J.; Koivumäki, M.; Ashton, N. J.; Lantero-Rodriguez, J.; Karikari, T. K.; Helin, S.; Bucci, M.; Löyttyniemi, E.; Parkkola, R.; Karrash, M.; Schöll, M.; Zetterberg, H.; Blennow, K.; Rinne, J.
10.1101/2022.09.19.508484 — neuroscience — Posted on 2022-09-20
1659 Dysregulation of mTOR Signaling Mediates Common Neurite and Migration Defects in Both Idiopathic and 16p11.2 Deletion Autism Neural Precursor Cells
Prem, S.; Dev, B.; Peng, C.; Mehta, M.; Alibutud, R.; Connacher, R. J.; St. Thomas, M.; Zhou, X.; Matteson, P.; Xing, J.; Millonig, J.; DiCicco-Bloom, E.
10.1101/2022.09.17.508382 — neuroscience — Posted on 2022-09-20
1660 Defining the chromatin and transcriptional landscape of stem cell-derived islets
Augsornworawat, P.; Hogrebe, N. J.; Ishahak, M.; Marquez, E.; Maestas, M. M.; Schmidt, M. D.; Veronese-Paniagua, D. A.; Gale, S. E.; Miller, J. R.; Velazco-Cruz, L.; Millman, J. R.
10.1101/2022.02.26.482126 — cell biology — Posted on 2022-09-20
1661 Structural evolution of an immune evasion determinant shapes Lyme borreliae host tropism
Marcinkiewicz, A. L.; Brangulis, K.; Dupuis, A. P.; Hart, T. M.; Zamba_Campero, M.; Nowak, T. A.; Stout, J. L.; Akopjana, I.; Kazaks, A.; Bogans, J.; Ciota, A. T.; Kraiczy, P.; Kolokotronis, S.-O.; Lin, Y.-P.
10.1101/2022.09.13.507797 — microbiology — Posted on 2022-09-20
1666 Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells
Torres, J. M.; Sun, H.; Nylander, V.; Downes, D. J.; van de Bunt, M.; McCarthy, M. I.; Hughes, J. R.; Gloyn, A. L.
10.1101/2022.09.19.508549 — genetics — Posted on 2022-09-19
1668 Multi-lingual multi-platform investigations of online trade in jaguar parts
Polisar, J.; Davies, C.; Morcatty, T.; da Silva, M.; Zhang, S.; Duchez, K.; Madrid, J.; Lambert, A. E.; Gallegos, A.; Delgado, M.; Nguyen, H.; Wallace, R.; Arias, M.; Nijman, V.; Ramnarace, J.; Pennell, R.; Novelo, Y.; Rumiz, D.; Rivero, K.; Murillo, Y.; Salas, M. N.; Kretser, H.; Reuter, A.
10.1101/2022.09.19.508455 — ecology — Posted on 2022-09-19
1669 T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections
Santiago-Carvalho, I.; Almeida-Santos, G.; Macedo, B. G.; Bomfim, C. C. B.; Almeida, F. M.; Cione, M. V. P.; Vardam-Kaur, T.; Masuda, M.; van Dijk, S.; Melo, B. M.; Nascimento, R. S. d.; Souza, R. d. C.; Peixoto-Rangel, A. L.; Coutinho-Silva, R.; Hirata, M. H.; Alves-Filho, J. C.; Alvarez, J. M.; Lassounskaia, E.; da Silva, H. B.; Lima, M. R. D.
10.1101/2022.09.19.508603 — immunology — Posted on 2022-09-19
1670 Host genetic background is a barrier to vaccine-induced protection against infection
Lai, R.; Gong, D.; Williams, T.; Ogunsola, A. F.; Cavallo, K.; Arlehamn, C. L.; Beamer, G.; Ferris, M.; Sassetti, C. M.; Lauffenburger, D.; Behar, S.
10.1101/2022.09.19.508548 — immunology — Posted on 2022-09-19
1671 Genomic effects of the glucocorticoid receptor guide the acute stress-induced delayed anxiety and basolateral amygdala spine plasticity in rats
Novaes, L. S.; Bueno-de-Camargo, L. M.; Shigeo-de-Almeida, A.; Juliano, V. A. L.; Dos Santos, N. B.; Goosens, K.; Munhoz, C. D.
10.1101/2022.09.19.508565 — neuroscience — Posted on 2022-09-19
1672 A multiplex platform to identify mechanisms and modulators of proteotoxicity in neurodegeneration
Resnick, S. J.; Qamar, S. S.; Sheng, J.; Huang, L. H.; Nixon-Abell, J.; Melore, S.; Chung, C. W.; Li, X.; Wang, J.; Zhang, N.; Shneider, N. A.; Kaminski, C. F.; Ruggeri, F. S.; Schierle, G. S. K.; St George-Hyslop, P.; Chavez, A.
10.1101/2022.09.19.508444 — neuroscience — Posted on 2022-09-19
1674 Efficacy of a Growth Hormone-Releasing Hormone Agonist in a Murine Model of Cardiometabolic Heart Failure with Preserved Ejection Fraction
Takeuchi, R. M. K.; Takeuchi, L. M.; Dulce, R. A.; Kazmierczak, K.; Balkan, W.; Cai, R.; Sha, W.; Schally, A. V.; Hare, J. M.
10.1101/2022.09.18.508429 — physiology — Posted on 2022-09-19
1675 Cryo-EM of prion strains from the same genotype of host identifies conformational determinants
Hoyt, F.; Alam, P.; Artikis, E.; Schwartz, C. L.; Hughson, A. G.; Race, B.; Baune, C.; Raymond, G. J.; Baron, G. S.; Kraus, A.; Caughey, B.
10.1101/2022.09.19.508587 — biophysics — Posted on 2022-09-19
1677 Ciliary propulsion and metachronal coordination in reef coral larvae
Poon, R. N.; Westwood, T. A.; Laeverenz-Schlogelhofer, H.; Broderick, E.; Craggs, J.; Keaveny, E. E.; Jekely, G.; Wan, K. Y.
10.1101/2022.09.19.508546 — biophysics — Posted on 2022-09-19
1680 Synthetic maize centromeres transmit chromosomes across generations
Dawe, R. K.; Gent, J. I.; Zeng, Y.; Zhang, H.; Fu, F.-F.; Wang, N.; Kim, D. W.; Swentowsky, K. W.; Liu, J.; Piri, R. D.
10.1101/2022.09.19.508542 — genetics — Posted on 2022-09-19
1681 Minimal cell JCVI-syn3B as a chassis to reveal the mechanisms behind Mycoplasma host-pathogen interactions
Bittencourt, D. M. d. C.; Brown, D. M.; Assad-Garcia, N.; Lynott, M. R.; Sun, L.; Melo, L. A. M. P. d.; Freire, M.; Glass, J. I.
10.1101/2022.09.19.508583 — microbiology — Posted on 2022-09-19
1683 Mycobacterial exposure remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection
Mai, D.; Jahn, A.; Murray, T.; Morikubo, M.; Nemeth, J. C.; Urdahl, K. B.; Diercks, A. H.; Aderem, A.; Rothchild, A. C.
10.1101/2022.09.19.507309 — immunology — Posted on 2022-09-19
1684 Inducible CRISPR epigenome systems mimic cocaine induced bidirectional regulation of Nab2 and Egr3
Choi, E. Y.; Franco, D.; Stapf, C. A.; Gordin, M.; Chow, A.; Cover, K. K.; Chandra, R.; Lobo, M. K.
10.1101/2022.09.19.508525 — neuroscience — Posted on 2022-09-19
1686 Widespread, perception-related information in the human brain scales with levels of consciousness
Vigotsky, A. D.; Jabakhanji, R.; Branco, P.; Iannetti, G. D.; Baliki, M. N.; Apkarian, A. V.
10.1101/2022.09.19.508437 — neuroscience — Posted on 2022-09-19
1688 A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo.
Morsli, S.; Henriques, C.; Ellis, P. s.; Mortiboys, H. J.; Baxendale, S.; Loynes, C. A.; Renshaw, S.; Bellantuono, I.
10.1101/2022.09.19.506911 — pharmacology and toxicology — Posted on 2022-09-19
1694 Aortic Shape Space Topology
Khabaz, K.; Sankary, S.; Yuan, K.; Pugar, J.; Kim, J.; Kang, J.; Nguyen, N.; Cao, K.; Pierce, N.; Lee, C. J.; Milner, R.; Kindlmann, G.; Pocivavsek, L.
10.1101/2022.09.19.508582 — bioengineering — Posted on 2022-09-19
1698 Annelid functional genomics reveal the origins of bilaterian life cycles
Martin-Zamora, F. M.; Liang, Y.; Guynes, K.; Carrillo-Baltodano, A.; Davies, B. E.; Donnellan, R. D.; Mortimer, K.; Tan, Y.; Moggioli, G.; Seudre, O.; Tran, M.; Luscombe, N.; Hejnol, A.; Marletaz, F.; Martin-Duran, J. M.
10.1101/2022.02.05.479245 — genomics — Posted on 2022-09-19
1700 Evolutionary insights reveal a new role of PADI2 in transcriptional elongation
Villanueva-Canas, J. L.; Fernandez-Fuentes, N.; Teyssier, C.; Rogalska, M. E.; Perez, F. P.; Oliva, B.; Notredame, C.; Beato, M.; Sharma, P.
10.1101/2022.09.19.508513 — evolutionary biology — Posted on 2022-09-19
1702 The genomic basis of hybrid male sterility in Ficedula flycatchers
Segami Marzal, J. C.; Mugal, C. F.; Cunha, C.; Bergin, C.; Schmitz, M.; Semon, M.; Qvarnstrom, A.
10.1101/2022.09.19.508503 — evolutionary biology — Posted on 2022-09-19
1704 The homeobox transcription factor DUXBL controls exit from totipotency
Vega-Sendino, M.; Olbrich, T.; Stein, P.; Tillo, D.; Carey, G. I.; Savy, V.; Saykali, B.; Domingo, C. N.; Maity, T. K.; Jenkins, L. M.; Williams, C. J.; Ruiz, S.
10.1101/2022.09.19.508541 — developmental biology — Posted on 2022-09-19
1705 Notch directs telencephalic development and neuron fate determination by regulating miRNA levels
Han, J. S.; Fishman-Williams, E. K.; Decker, S. C.; Hino, K. K.; Reyes, R. V.; Brown, N. L.; Simo, S.; La Torre, A.
10.1101/2022.09.16.508220 — developmental biology — Posted on 2022-09-19
1710 Systems biology illuminates alternative metabolic niches in the human gut microbiome
Noecker, C.; Sanchez, J.; Bisanz, J. E.; Escalante, V.; Alexander, M.; Trepka, K.; Heinken, A.; Liu, Y.; Dodd, D.; Thiele, I.; DeFelice, B.; Turnbaugh, P. J.
10.1101/2022.09.19.508335 — microbiology — Posted on 2022-09-19
1711 Long-read powered viral metagenomics in the oligotrophic Sargasso Sea
Warwick-Dugdale, J. L.; Tian, F.; Michelsen, M. L.; Cronin, D. R.; Moore, K.; Farbos, A.; Chittick, L.; Bell, A.; Buchholz, H. H.; Parsons, R. J.; Zayed, A. A.; Allen, M. J.; Sullivan, M. B.; Temperton, B.
10.1101/2022.09.19.508504 — microbiology — Posted on 2022-09-19
1712 Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans
Locher, V.; Park, S.; Bunis, D.; Makredes, S.; Burt, T. D.; Fragiadakis, G. K.; Halkias, J.
10.1101/2022.09.19.508328 — immunology — Posted on 2022-09-19
1713 Influenza infection recruits distinct waves of regulatory T cells to the lung that limit lung resident IgA+ B cells
Sjaastad, L. E.; Owen, D. L.; Joo, S.; Knutson, T. P.; O'Connor, C. H.; McClusky, B.; LaRue, R. S.; Langlois, R. A.; Farrar, M. A.
10.1101/2022.09.19.508325 — immunology — Posted on 2022-09-19
1717 Secreted long non-coding RNAs Gadlor1 and Gadlor2 affect multiple cardiac cell types and aggravate cardiac remodeling during pressure overload
Keles, M.; Grein, S.; Froese, N.; Wirth, D.; Trogisch, F. A.; Wardman, R.; Hemanna, S.; Weinzierl, N.; Uhlig, S.; Lomada, S.; Dittrich, G. M.; Szaroszyk, M.; Haustein, R.; Hegermann, J.; Martin Garrido, A.; Bauersachs, J.; Frank, D.; Frey, N.; Bieback, K.; Cordero, J.; Dobreva, G.; Wieland, T.; Heineke, J.
10.1101/2022.09.19.508486 — systems biology — Posted on 2022-09-19
1718 A lineage tree-based hidden Markov model to quantify cellular heterogeneity and plasticity
Mohammadi, F.; Visagan, S.; Gross, S. M.; Karginov, L.; Lagarde, J.; Heiser, L. M.; Meyer, A. S.
10.1101/2021.06.25.449922 — systems biology — Posted on 2022-09-19
1719 The chromosome-level genome of Water-Wisteria establishes an ecological plant model and provides insight into the molecular mechanisms underlying heterophylly in amphibious plants
Li, G.; Zhao, X.; Yang, J.; Chen, Y.; Chen, Y.; Li, Y.; Sun, Z.; Xia, M.; Wang, X.; Li, X.; Luo, K.; Hu, S.; Ponnu, J.; Kimura, S.; Hwang, I.; Torii, K. U.; Hou, H.
10.1101/2022.09.19.508473 — plant biology — Posted on 2022-09-19
1720 Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products
Bayless, A. M.; Chen, S.; Ogden, S. C.; Xu, X.; Sidda, J. D.; Manik, M. K.; Li, S.; Kobe, B.; Ve, T.; Song, L.; Grant, M.; Wan, L.; Nishimura, M. T.
10.1101/2022.09.19.508568 — plant biology — Posted on 2022-09-19
1723 Body condition score and triglyceride concentrations and their associations with other markers of energy homeostasis in healthy, non-obese dogs
Gomez-Fernandez-Blanco, C.; Peeters, D.; Farnir, F.; Höglund, K.; Vassiliki, G.; Maria, W.; Lundgren Willesen, J.; Hanas, S.; McEntee, K.; Tiret, L.; Häggström, J.; Hannes, L.; Chetboul, V.; Fredholm, M.; Seppälä, E.; Lequarre, A.-S.; German, A. J.; Merveille, A.-C.
10.1101/2022.09.19.508523 — physiology — Posted on 2022-09-19
1724 The relaxin receptor RXFP1 signals through a mechanism of autoinhibition
Erlandson, S. C.; Rawson, S.; Osei-Owusu, J.; Brock, K. P.; Liu, X.; Paulo, J. A.; Mintseris, J.; Gygi, S. P.; Marks, D. S.; Cong, X.; Kruse, A. C.
10.1101/2022.01.22.477343 — pharmacology and toxicology — Posted on 2022-09-19
1725 In-vivo antidiarrheal activity: From the crude extract and solvent fractions of Rhamnus prinoides (Rhamnaceae) leaves
Mengie, T.; Abebe, E. C.; Muche, Z. T.; Agidew, M. M.; Yimer, Y. S.; Addis, G. T.; Baye, N. D.; Kassie, A. B.; Alemu, M. A.; Yiblet, T. G.; Tiruneh, G. A.; Dagnew, S. B.; Moges, T. A.; Tadesse, T. Y.; Zelalem, A. E.
10.1101/2022.09.19.508518 — pharmacology and toxicology — Posted on 2022-09-19
1728 Cancer-associated SMARCAL1 loss-of-function mutations promote alternative lengthening of telomeres and tumorigenesis in telomerase-negative glioblastoma cells
Liu, H.; Xu, C.; Diplas, B. H.; Brown, A.; Strickland, L. M.; Ling, J.; McLendon, R. E.; Keir, S. T.; Ashley, D. M.; He, Y.; Waitkus, M. S.
10.1101/2022.09.19.507319 — cancer biology — Posted on 2022-09-19
1730 Deciphering the alphabet of disorder -- Glu and Asp act differently on local but not global properties
Roesgaard, M. A.; Lundsgaard, J. E.; Newcombe, E. A.; Jacobsen, N. L.; Pesce, F.; Tranchant, E. E.; Lindemose, S.; Prestel, A.; Hartmann-Petersen, R.; Lindorff-Larsen, K.; Kragelund, B. B.
10.1101/2022.08.25.505250 — biophysics — Posted on 2022-09-19
1731 Organization and regulation of nuclear condensates by gene activity
Schede, H. H.; Natarajan, P.; Chakraborty, A. K.; Shrinivas, K.
10.1101/2022.09.19.508534 — biophysics — Posted on 2022-09-19
1737 Single and Multi-trait Genomic Prediction for agronomic traits in Euterpe edulis
Canal, G. B.; Barreto, C. A. V.; de Almeida, F. A. N.; Zaidan, I. R.; do Couto, D. P.; Azevedo, C. F.; Nascimento, M.; Ferreira, M. F. d. S.; Ferreira, A.
10.1101/2022.09.19.508517 — genetics — Posted on 2022-09-19
1739 Artisanal and farmers bread making practices differently shape fungal species community composition in French sourdoughs
Michel, E.; Masson, E.; Bubbendorf, S.; Lapicque, L.; Nidelet, T.; Segond, D.; Guezenec, S.; Marlin, T.; Devillers, H.; Rue, O.; Onno, B.; Legrand, J.; Sicard, D.
10.1101/679472 — ecology — Posted on 2022-09-19
1741 The molecular mechanism of chloramphenicol and thiamphenicol resistance mediated by a novel oxidase CmO in Sphingomonadaceae
Ma, X.; Zhang, L.; Ren, Y.; Yun, H.; Cui, H.; Li, Q.; Guo, Y.; Gao, S.; Zhang, F.; Wang, A.; Liang, B.
10.1101/2022.09.18.508450 — microbiology — Posted on 2022-09-19
1743 Guild-level microbiome signature associated with COVID-19 severity and prognosis
Guo, M.; Wu, G.; Tan, Y.; Li, Y.; Jin, X.; Qi, W.; Guo, X.; Zhang, C.; Zhu, Z.; Zhao, L.
10.1101/2022.09.18.508418 — microbiology — Posted on 2022-09-19
1744 A Toll pathway effector protects Drosophila specifically from distinct toxins secreted by a fungus or a bacterium
Hunag, J.; Lou, Y.; Liu, J.; Bulet, P.; Jiao, R.; Hoffmann, J. A.; Liegeois, S.; Li, Z.; FERRANDON, D.
10.1101/2020.11.23.394809 — immunology — Posted on 2022-09-19
1745 A model-free approach to link neural activity to behavioral tasks
Costabile, J. D.; Balakrishnan, K. A.; Schwinn, S.; Haesemeyer, M.
10.1101/2022.08.31.506108 — neuroscience — Posted on 2022-09-19
1748 Functional analysis of V2 protein of Beet curly top Iran virus
Bahari, A.; Castillo Garriga, A.; Safaie, N.; Bejarano, E. R.; Luna, A. P.; Shams-Bakhsh, M.
10.1101/2022.09.19.508497 — plant biology — Posted on 2022-09-19
1749 Optimal transport analysis of single-cell transcriptomics directs hypotheses prioritization and validation
Singh, R.; Li, J. S. S.; Tattikota, S. G.; Liu, Y.; Xu, J.; Hu, Y.; Perrimon, N.; Berger, B.
10.1101/2022.06.27.497786 — bioinformatics — Posted on 2022-09-19
1751 Poly-omic risk scores predict inflammatory bowel disease diagnosis
Arehart, C. H.; Sterrett, J. D.; Garris, R. L.; Quispe-Pilco, R. E.; Gignoux, C. R.; Evans, L. M.; Stanislawski, M. A.
10.1101/2022.09.14.508056 — bioinformatics — Posted on 2022-09-19
1752 Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM
Valerie, N. C. K.; Sanjiv, K.; Mortusewicz, O.; Zhang, S. M.; Rasti, A.; Langelier, M.-F.; Rehling, D.; Throup, A.; Desroses, M.; Wakchaure, P.; Almlof, I.; Alam, S.; Bostrom, J.; Bevc, L.; Stenmark, P.; Pascal, J. M.; Helleday, T.; Page, B. D. G.; Altun, M.
10.1101/2022.09.19.505646 — biochemistry — Posted on 2022-09-19
1753 Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 using Proximity Labeling and Affinity Purification
Aprosoff, C. M.; Dyakov, B. J. A.; Cheung, V. H. W.; Wong, C. J.; Palandra, M.; Gingras, A.-C.; Wyatt, H. D. M.
10.1101/2022.09.19.508447 — biochemistry — Posted on 2022-09-19
1755 Genomics of PDGFR-rearranged hypereosinophilic syndrome
Rheinbay, E.; Qi, M.; Bouyssou, J.; Oler, A. J.; Thumm, L.; Makiya, M.; Maric, I.; Klion, A.; Lane, A.
10.1101/2022.09.19.508443 — genomics — Posted on 2022-09-19
1758 A Novel Gene REPTOR2 Activates the Autophagic Degradation of Wing Disc in pea aphid
Yuan, E.; Guo, H.; Chen, W.; Du, B.; Mi, Y.; Qi, Z.; Yuan, Y.; Zhu-Salzman, K.; Ge, F.; Sun, Y.
10.1101/2022.09.19.508482 — developmental biology — Posted on 2022-09-19
1759 Comparative transcriptomics reveals human-specific cortical features
Jorstad, N. L.; Song, J. H. T.; Exposito-Alonso, D.; Suresh, H.; Castro, N.; Krienen, F. M.; Yanny, A. M.; Close, J.; Gelfand, E.; Travaglini, K. J.; Basu, S.; Beaudin, M.; Bertagnolli, D.; Crow, M.; Ding, S.-L.; Eggermont, J.; Glandon, A.; Goldy, J.; Kroes, T.; Long, B.; McMillen, D.; Pham, T.; Rimorin, C.; Siletti, K.; Somasundaram, S.; Tieu, M.; Torkelson, A.; Ward, K.; Feng, G.; Hopkins, W. D.; Hollt, T.; Keene, C. D.; Linnarsson, S.; McCarroll, S. A.; Lelieveldt, B. P.; Sherwood, C. C.; Smith, K.; Walsh, C. A.; Dobin, A.; Gillis, J.; Lein, E. S.; Hodge, R. D.; Bakken, T. E.
10.1101/2022.09.19.508480 — neuroscience — Posted on 2022-09-19
1761 The vestibular calyceal junction is dismantled in response to diverse injuring stimuli in rats and humans
Maroto, A. F.; Borrajo, M.; Prades, S.; Callejo, A.; Amilibia, E.; Perez-Grau, M.; Roca-Ribas, F.; Castellanos, E.; Barrallo-Gimeno, A.; Llorens, J.
10.1101/2022.05.17.492294 — neuroscience — Posted on 2022-09-19
1765 Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in enteric nervous system
Ito, M.; Fujii, N.; Kohara, S.; Hori, S.; Tanaka, M.; Wittwer, C.; Kikuchi, K.; Iijima, T.; Kakimoto, Y.; Hirabayashi, K.; Kurotaki, D.; Jessen, H. J.; Saiardi, A.; Nagata, E.
10.1101/2022.09.19.508459 — molecular biology — Posted on 2022-09-19
1767 Loss of Rab8a in B cells leads to increased antibody responses and class-switch recombination
Hernandez-Perez, S.; Sarapulov, A. V.; Balci, M. O.; Coffey, E.; Harada, A.; Mattila, P.
10.1101/2022.09.19.508414 — immunology — Posted on 2022-09-19
1768 HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era
Buhler, S.; Calderin Sollet, Z.; Bettens, F.; Schaefer, A.; Ansari, M.; Ferrari-Lacraz, S.; Villard, J.
10.1101/2022.09.14.507948 — immunology — Posted on 2022-09-19
1769 Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies
Sheward, D. J.; Kim, C.; Fischbach, J.; Muschiol, S.; Ehling, R. A.; Björkström, N. K.; Karlsson Hedestam, G. B.; Reddy, S. T.; Albert, J.; Peacock, T. P.; Murrell, B.
10.1101/2022.09.16.508299 — immunology — Posted on 2022-09-19
1772 Reduced insulin signalling in neurons induces sex-specific health benefits
Baghdadi, M.; Nespital, T.; Mesaros, A.; Buschbaum, S.; Withers, D. J.; Grönke, S.; Partridge, L.
10.1101/2022.09.19.508502 — neuroscience — Posted on 2022-09-19
1777 OPA1 Downregulation in Skeletal Muscle Induces MERC formation in an ATF4-Dependent Manner
Hinton, A.; Katti, P.; Mungai, M.; Hall, D.; Koval, O.; Shao, J.; Vue, Z.; Christensen, T. A.; Lopez, E. G.; Rostami, R.; Neikirk, K.; Lam, J.; Alghanem, A.; Ponce, J.; Hicsasmaz, I.; Streeter, J.; Schickling, B.; Bacevac, S.; Grueter, C.; Marshall, A.; Beasley, H. K.; DoKoo, Y.; Bodine, S.; Nava, N. G. R.; Quintana, A.; Trushina, E.; Weatherford, E.; Murray, S. A.; Salisbury, J.; Song, L.-S.; Grumbach, I.; Exil, V.; Pereira, R. O.; Glancy, B.; Abel, E. D.
10.1101/2022.09.12.507669 — biophysics — Posted on 2022-09-19
1781 Using pressure-driven flow systems to evaluate laser speckle contrast imaging
Sullender, C. T.; Santorelli, A.; Richards, L. M.; Mannava, P. K.; Smith, C.; Dunn, A. K.
10.1101/2022.09.16.508276 — bioengineering — Posted on 2022-09-19
1786 Effect and mechanism of black soybean peptides alleviating oxidative damage in the celiac disease cell model
Cui, C.; Wang, N.; Gao, E.; Yu, Q.; Sun, X.; Hu, M.; Xu, Q.; Cui, N.; Zheng, Y.; Wang, F.; Wang, C.
10.1101/2022.09.19.508472 — cell biology — Posted on 2022-09-19
1787 Pathogens in exacerbations of chronic rhinosinusitis differ in sensitivity to silver nanoparticles
Szaleniec, J.; Gibala, A.; Stalinska, J.; Ocwieja, M.; Zeliszewska, P.; Drukala, J.; Szaleniec, M.; Gosiewski, T.
10.1101/2022.01.03.474872 — microbiology — Posted on 2022-09-19
1788 Staphylococcus aureus virulence factor expression matters: input from targeted proteomics shows Panton-Valentine leucocidin impact on mortality
Pivard, M.; Bastien, S.; Macavei, I.; Mouton, N.; Rasigade, J.-P.; Couzon, F.; Carriere, R.; Moreau, K.; Lemoine, J.; Vandenesch, F.
10.1101/2022.09.18.508069 — microbiology — Posted on 2022-09-19
1789 HDAC7 controls anti-viral and anti-tumor immunity by CD8+ T cells
Yerinde, C.; Keye, J.; Durlanik, S.; Freise, I.; Nowak, F.; Hsiao, H.-J.; Letizia, M.; Schlickeiser, S.; Obermayer, B.; Huck, A.; Friedrich, M.; Wu, H.; Kunkel, D.; Kuehl, A. A.; Bauer, S.; Thiel, A.; Siegmund, B.; Glauben, R.; Weidinger, C.
10.1101/2022.09.18.508452 — immunology — Posted on 2022-09-19
1791 Abnormal intrinsic neural timescale in Parkinson's disease
Wei, Y.; Zhang, C.; Peng, Y.; Chen, C.; Han, S.; Wang, W.; Lu, H.; Cheng, J.
10.1101/2022.09.17.508074 — neuroscience — Posted on 2022-09-19
1793 Relative Brain Age Is Associated with Socioeconomic Status and Anxiety/Depression Problems in Youth
Cohen, J. W.; Ramphal, B.; Deserisy, M.; Zhao, Y.; Pagliaccio, D.; Colcombe, S.; Milham, M. P.; Margolis, A. E.
10.1101/2022.09.15.505331 — neuroscience — Posted on 2022-09-19
1795 The Role of Frontal Eye Field in Saccadic Mixed-strategy Decision-making
Xie, S.; Abunafessa, A.; Gu, Y.; Yang, M.; Wang, X.; Tu, J.; Thevarajah, D.; Dorris, M. C.
10.1101/2022.09.18.508403 — neuroscience — Posted on 2022-09-19
1799 Towards genome-engineering in complex cyanobacterial communities: RNA-guided transposition in Anabaena
Arevalo, S.; Rico, D. P.; Abarca, M. D.; Dijkhuizen, L. W.; Lindblad, P.; Flores, E.; Nierzwicki-Bauer, S.; Schluepmann, H.
10.1101/2022.09.18.508393 — synthetic biology — Posted on 2022-09-19
1802 A deep learning workflow for quantification of Micronuclei in DNA damage studies in cultured cancer cell lines: a proof of principle investigation
Surendranath, K.; Panchbhai, A.; Ishanzadeh, M. C.; Pankanti, S.; Sidali, A.; Solaiman, N.; Radhakrishnan, K.; Murphy, J. J.
10.1101/2022.09.18.508405 — cancer biology — Posted on 2022-09-19
1805 FrameRate: learning the coding potential of unassembled metagenomic reads
Liu-Wei, W.; Aubrey, W.; Clare, A.; Hoehndorf, R.; Creevey, C. J.; Dimonaco, N. J.
10.1101/2022.09.16.508314 — bioinformatics — Posted on 2022-09-19
1806 ADRA2B and HTR1A: An updated study of the biogenic amine receptors reveals novel conserved motifs which play key role in Mental Disorders.
Papageorgiou, L.; Christou, E.; Louka, E.; Andreou, A.; Papakonstantinou, E.; Diakou, I.; Pierouli, K.; Dragoumani, K.; Bacopoulou, F.; Chrousos, G. P.; Eliopoulos, E.; Vlachakis, D.
10.1101/2022.09.16.508280 — bioinformatics — Posted on 2022-09-19
1808 Predicting A/B compartments from histone modifications using deep learning
Zheng, S.; Thakkar, N.; Harris, H. L.; Zhang, M.; Liu, S.; Gerstein, M.; Aiden, E. L.; Rowley, J.; Noble, W. S.; Gursoy, G.; Singh, R.
10.1101/2022.04.19.488754 — bioinformatics — Posted on 2022-09-19
1809 Towards In-Silico CLIP-seq: Predicting Protein-RNA Interaction via Sequence-to-Signal Learning
Horlacher, M.; Wagner, N.; Moyon, L.; Kuret, K.; Goedert, N.; Salvatore, M.; Ule, J.; Gagneur, J.; Winther, O.; Marsico, A.
10.1101/2022.09.16.508290 — bioinformatics — Posted on 2022-09-19
1810 Genetic, clinical underpinnings of subtle early brain change along Alzheimer's dimensions
WEN, J.; Yang, Z.; Nasrallah, I.; Cui, Y.; Erus, G.; Srinivasan, D.; Abdulkadir, A.; Mamourian, E.; Hwang, G.; Singh, A.; Bergman, M.; Bao, J.; Varol, E.; Zhou, Z.; Boquet-Pujadas, A.; Chen, J.; Toga, A. W.; Saykin, A. J.; Hohman, T.; Thompson, P.; Villeneuve, S.; Gollub, R.; Sotiras, A.; Wittfeld, K.; Grabe, H.; Tosun, D.; Bilgel, M.; An, Y.; Marcus, D.; LaMontagne, P. J.; Heckbert, S.; Austin, T.; Launer, L.; Espeland, M.; Masters, C.; Maruff, P.; Fripp, J.; Johnson, S. C.; Morris, j.; Albert, M.; Nick, R.; Resnick, S. M.; Ferrucci, L.; Fan, Y.; Mohamad, H.; Wolk, D.; Shen, L.; Shou, H.; Dav
10.1101/2022.09.16.508329 — bioengineering — Posted on 2022-09-19
1811 Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem
Wei, J.; Hua, Y.; Yang, B.; Wang, B.; Schmitt, S. E.; Wang, B.; Lucy, K. A.; Ishikawa, H.; Schuman, J. S.; Smith, M. A.; Wollstein, G.; Sigal, I. A.
10.1101/2022.09.18.508448 — bioengineering — Posted on 2022-09-19
1812 The Mouse N-Glycome Atlas - High-resolution N-glycan analysis of 23 mouse tissues.
Helm, J.; Mereiter, S.; Oliveira, T.; Penninger, J. M.; Altmann, F.; Stadlmann, J.
10.1101/2022.09.19.508483 — biochemistry — Posted on 2022-09-19
1813 A benchmarking of human Y-chromosomal haplogroup classifiers from whole-genome and whole-exome sequence data
Garcia-Olivares, V.; Munoz-Barrera, A.; Rubio Rodriguez, L. A.; Jaspez, D.; Diaz de-Usera, A.; Inigo Campos, A.; Veeramah, K. R.; Alonso, S.; Thomas, M. G.; Gonzalez-Montelongo, R.; Lorenzo-Salazar, J. M.; Flores, C.
10.1101/2022.09.19.508481 — genomics — Posted on 2022-09-19
1814 TransCistor reveals the landscape of cis-regulatory long noncoding RNAs
Chouvardas, P.; Zimmerli, M.; Hanhart, D.; Moser, M.; Guillen-Ramirez, H. A.; Mishra, S.; Esposito, R.; Polidori, T.; Widmer, M.; Garcia-Perez, R.; Kruithof-de Julio, M.; Pervouchine, D. D.; Mele, M.; Johnson, R.
10.1101/2022.09.18.508380 — genomics — Posted on 2022-09-19
1820 Transient Polycomb activity represses developmental genes in growing oocytes.
Jarred, E. G.; Qu, Z.; Tsai, T.; Oberin, R.; Petautschnig, S.; Bildsoe, H.; Pederson, S. M.; Zhang, Q.-H.; Stringer, J. M.; Carroll, J.; Gardner, D. K.; van den Buuse, M.; Sims, N.; Gibson, W.; Adelson, D. L.; Western, P. S.
10.1101/2022.09.18.508436 — developmental biology — Posted on 2022-09-19
1822 Chance and contingency in B cell evolution limit the similarity of antibody responses to infection across individuals
Vieira, M. C.; Palm, A.-K. E.; Stamper, C. T.; Tepora, M. E.; Nguyen, K. D.; Pham, T. D.; Boyd, S. D.; Wilson, P. C.; Cobey, S.
10.1101/2022.09.16.508315 — immunology — Posted on 2022-09-19
1823 Multi-modal Efficacy of a Chimeric Vesiculovirus Expressing the Morreton Glycoprotein in Sarcoma
Dumbauld, C.; Barro, O.; Elliott, N. M.; Zhou, Y.; Gabere, M.; Raupach, E.; Baker, A. T.; Barrett, M. T.; Buetow, K.; Jacobs, B.; Seetharam, M.; Borad, M.; Nagalo, B. M.
10.1101/2022.09.18.508434 — immunology — Posted on 2022-09-19
1824 Microbiota-stimulated Interleukin-22 regulates brain neurons and protects against stress-induced anxiety
Ilanges, A.; Xia, M.; Lu, J.; Chen, L.; Shiao, R.; Wang, C.; Feng, R.; Jin, Z.; Yi, H.; Qi, Q.; Li, J.; Schneeberger, M.; Lu, B.; Friedman, J. M.; Yu, X.
10.1101/2022.09.16.508224 — immunology — Posted on 2022-09-19
1827 Cascades of neuronal plasticity in the macaque visual cortex
Koyano, K. W.; Esch, E. M.; Hong, J. J.; Waidmann, E. N.; Leopold, D. A.
10.1101/2022.09.17.508292 — neuroscience — Posted on 2022-09-19
1832 Loss of LRP1 from GABAergic neurons impairs short-term memory function
Uner, A. A.; Hou, Z.-S.; Aydogan, A.; Rodrigues, K. C. d. C.; Young, J.; Choi, A.; Yang, W.-M.; Kang, J.; Kim, W.; PREVOT, V.; Caldarone, B. J.; Lee, H.; Kim, Y.-B.
10.1101/2022.09.17.508390 — neuroscience — Posted on 2022-09-19
1834 Mental fatigue impairs physical performance but not the neural drive to the muscle
Alix-Fages, C.; Jimenez-Martinez, P.; Souza de Oliveira, D.; Mock, S.; Balsalobre-Fernandez, C.; Del Vecchio, A.
10.1101/2022.09.16.508212 — physiology — Posted on 2022-09-19
1837 A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer
Mayoh, C.; Gifford, A.; Terry, R.; Lau, L. M.; Wong, M.; Rao, P.; Shai-Hee, T.; Saletta, F.; Khuong-Quang, D.-A.; Qin, V.; Mateos, M.; Meyran, D.; Miller, K. E.; Yuksel, A.; Mould, E. V.; Bowen-James, R.; Govender, D.; Senapati, A.; Zhukova, N.; Omer, N.; Dholaria, H.; Alvaro, F.; Tapp, H.; Diamond, Y.; Dalla Pozza, L.; Moore, A. S.; Nicholls, W.; Gottardo, N. G.; McCowage, G.; Hansford, J. R.; Khaw, S.-L.; Wood, P. J.; Catchpoole, D.; Cottrell, C. E.; Mardis, E. R.; Marshall, G. M.; Tyrrell, V.; Haber, M.; Ziegler, D. S.; Vittorio, O.; Trapani, J. A.; Cowley, M. J.; Neeson, P. J.; Ekert, P. G
10.1101/2022.09.16.508179 — cancer biology — Posted on 2022-09-19
1838 Cells in the Polyaneuploid Cancer Cell (PACC) state have increased metastatic potential
Mallin, M. M.; Kim, N.; Choudhury, M. I.; Lee, S. J.; An, S. S.; Sun, S. X.; Konstantopoulos, K.; Pienta, K. J.; Amend, S. R.
10.1101/2022.09.16.508155 — cancer biology — Posted on 2022-09-19
1839 Functional precision profiling reveals non-mutational rewiring of kinase signaling networks in colorectal cancer
Plattner, C.; Lamberti, G.; Blattmann, P.; Kirchmair, A.; Rieder, D.; Loncova, Z.; Sturm, G.; Scheidl, S.; Ijsselsteijn, M. E.; Fotakis, G.; Noureen, A.; Lisandrelli, R.; Boeck, N.; Nemati, N.; Krogsdam, A.; Daum, S.; Finotello, F. E.; Somarakis, A.; Schaefer, A.; Wilflingseder, D.; Gonzalez Acera, M.; Oefner, D.; Huber, L. A.; Clevers, H.; Becker, C.; Farin, H. F.; Greten, F. R.; Aebersold, R.; da Cunha Carvalho de Miranda, N. F.; Trajanoski, Z.
10.1101/2022.09.16.508204 — cancer biology — Posted on 2022-09-19
1840 DRDs and Brain Derived Neurotrophic Factor share a common therapeutic ground: A novel bioinformatic approach sheds new light towards pharmacological treatment of Cognitive and Behavioral Disorders.
Papageorgiou, L.; Kalospyrou, E.; Papakonstantinou, E.; Diakou, I.; Pierouli, K.; Dragoumani, K.; Bacopoulou, F.; Chrousos, G. P.; Exarchos, T. P.; Vlamos, P.; Eliopoulos, E.; Vlachakis, D.
10.1101/2022.09.16.508267 — bioinformatics — Posted on 2022-09-19
1842 Compressed Data Structures for Population-Scale Positional Burrows-Wheeler Transforms
Bonizzoni, P.; Boucher, C.; Cozzi, D.; Gagie, T.; Kashgouli, S.; Köppl, D.; Rossi, M.
10.1101/2022.09.16.508250 — bioinformatics — Posted on 2022-09-19
1844 Comparison of calling pipelines for whole genome sequencing: an empirical study demonstrating the importance of mapping and alignment
Betschart, R.; Thiery, A.; Aguilera-Garcia, D.; Zoche, M.; Moch, H.; Twerenbold, R.; Zeller, T.; Blankenberg, S.; Ziegler, A.
10.1101/2022.09.18.508404 — bioinformatics — Posted on 2022-09-19
1846 Analysis of somatic mutations in senescent cells using single-cell whole-genome sequencing
Zhang, L.; De Cecco, M.; Lee, M.; Hao, X.; Maslov, A. Y.; Montagna, C.; Campisi, J.; Dong, X.; Sedivy, J. M.; Vijg, J.
10.1101/2022.09.16.508266 — genomics — Posted on 2022-09-19
1848 Differential transcriptomic responses to heat stress in surface and subterranean diving beetles
Beasley-Hall, P. G.; Bertozzi, T.; Bradford, T. M.; Foster, C. S. P.; Jones, K.; Tierney, S. M.; Humphreys, W. F.; Austin, A. D.; Cooper, S. J. B.
10.1101/2021.12.12.470823 — evolutionary biology — Posted on 2022-09-19
1851 Nutrient addition increases grassland resistance during dry and wet climate extremes despite functional diversity loss
Chen, Q.; Wang, S.-P.; Seabloom, E. W.; Isbell, F.; Borer, E. T.; Bakker, J. D.; Bharath, s.; Roscher, C.; Peri, P. L.; Power, S. A.; Donohue, I.; Stevens, C.; Ebeling, A.; Nogueira, C.; Caldeira, M. C.; MacDougall, A.; Moore, J.; Bagchi, S.; Jentsch, A.; Tedder, M.; Kirkman, K.; Alberti, J.; Hautier, Y.
10.1101/2022.09.16.508233 — ecology — Posted on 2022-09-19
1852 A new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
Reinhard, J.; Starke, L.; Klose, C.; Haberkant, P.; Hammaren, H.; Stein, F.; Klein, O.; Berhorst, C.; Stumpf, H.; Saenz, J. P.; Hub, J.; Schuldiner, M.; Ernst, R.
10.1101/2022.09.15.508072 — cell biology — Posted on 2022-09-19
1854 Historical biogeography of Cannabis in the Iberian Peninsula: palynological evidence
Rull, V.; Burjachs, F.; Carrion, J.; Ejarque, A.; Fernandez, S.; Lopez-Saez, J. A.; Luelmo-Lautenschlaeger, R.; Ochando, J.; Perez-Diaz, S.; Revelles, J.; Riera, S.; Rodriguez, S.
10.1101/2022.09.16.508344 — paleontology — Posted on 2022-09-19
1855 Mechanochemical rules for shape-shifting filaments that remodel membranes
Meadowcroft, B.; Palaia, I.; Pfitzner, A.-K.; Roux, A.; Baum, B.; Saric, A.
10.1101/2022.05.10.490642 — biophysics — Posted on 2022-09-19
1857 A non-coding A-to-T Kozak site change related to the transmissibility of Alpha, Delta and Omicron VOCs
Yang, J.; Zhang, G.; Yu, D.; Cao, R.; Wu, X.; Ling, Y.; Pan, Y.-H.; Yi, C.; Sun, X.; Sun, B.; Zhang, Y.; Zhao, G.-P.; Li, Y.; Li, H.
10.1101/2021.04.30.442029 — evolutionary biology — Posted on 2022-09-19
1860 Number and proportion of P. falciparum gametocytes vary from acute infection to chronic parasite carriage despite unaltered sexual commitment rate
van Dijk, H.; Ferreira Lima, N.; Kampmann, M.; Gabel, M.; Dabbas, U.; Doumbo, S.; Cisse, H.; Li, S.; Jeninga, M.; Thomson Luque, R.; Doumtabe, D.; Petter, M.; Kayentao, K.; Ongoiba, A.; Bousema, T.; Crompton, P. D.; Traore, B.; Graw, F.; Portugal, S.
10.1101/2021.11.05.467456 — microbiology — Posted on 2022-09-19
1861 Proinflammatory innate cytokines and metabolomic signatures shape the T cell response in active COVID-19
Binayke, A.; Zaheer, A.; Dandotiya, J.; Gupta, S. K.; Mani, S.; Tripathy, M. R.; Madan, U.; Shrivastava, T.; Kumar, Y.; Pandey, A. K.; Rathore, D. K.; Awasthi, A.
10.1101/2022.03.11.483930 — immunology — Posted on 2022-09-19
1862 Language and the cerebellum: structural connectivity to the eloquent brain
Jobson, K. R.; Hoffman, L. J.; Metoki, A.; Popal, H.; Dick, A. S.; Reilly, J.; Olson, I. R.
10.1101/2022.04.19.488812 — neuroscience — Posted on 2022-09-19
1863 Metabolic Signatures of Performance in Elite World Tour Professional Cyclists
Nemkov, T.; Cendali, F.; Stefanoni, D.; Martinez, J.; Hansen, K. C.; San-Millan, I.; D'Alessandro, A.
10.1101/2022.09.13.507793 — biochemistry — Posted on 2022-09-19
1865 Age and micronutrient effects on the microbiome in a mouse model of zinc depletion and supplementation
Davis, E. W.; Wong, C. P.; Arnold, H. K.; Kasschau, K.; Gaulke, C. A.; Sharpton, T. J.; Ho, E.
10.1101/2022.09.16.508248 — microbiology — Posted on 2022-09-19
1866 The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta.
Stroganov, S.; Harris, T.; Fellus-Alyagor, L.; Ben Moyal, L.; Plitman Mayo, R.; Golani, O.; Brandis, A.; Mehlman, T.; Kovo, M.; Biron-Shental, T.; Dekel, N.; Neeman, M.
10.1101/2022.09.14.507932 — physiology — Posted on 2022-09-19
1868 Lost In The Forest
Smith, H. L.; Biggs, P. J.; French, N. P.; Smith, A. N.; Marshall, J. C.
10.1101/2022.09.12.507676 — bioinformatics — Posted on 2022-09-19
1869 Common and distinct genetic architecture of age at diagnosis of diabetes in South Indian and European populations
Srinivasan, S.; Liju, S.; Sathish, N.; Siddiqui, M. K.; Ranjit, A. M.; Pearson, E. R.; Doney, A. S. F.; Viswanathan, M.; Venkatesan, R.; Palmer, C. N.
10.1101/2022.09.14.508063 — genetics — Posted on 2022-09-19
1871 Neurofibromin 1 mediates sleep depth in Drosophila
Brown, E. B.; Zhang, J.; Lloyd, E.; Lanzon, E.; Botero, V.; Tomchik, S.; Keene, A. C.
10.1101/2022.09.15.508161 — neuroscience — Posted on 2022-09-19
1872 Distinct brain networks for remote episodic memory depending on content and emotional value
Auguste, A. L.; Fourcaud-Trocme, N.; Meunier, D.; Gros, A.; Garcia, S.; Messaoudi, B.; Thevenet, M.; Ravel, N.; Veyrac, A.
10.1101/2022.09.16.508241 — neuroscience — Posted on 2022-09-19
1876 A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable foci
Hahn, O.; Foltz, A. G.; Atkins, M.; Kedir, B.; Moran-Losada, P.; Guldner, I. H.; Munson, C.; Kern, F.; Palovics, R.; Lu, N.; Kaur, A.; Hull, J.; Huguenard, J.; Keller, A.; Lehallier, B.; Wyss-Coray, T.
10.1101/2022.09.18.508419 — neuroscience — Posted on 2022-09-18
1877 Conserved whole-brain spatiomolecular gradients shape adult brain functional organization
Vogel, J. W.; Alexander-Bloch, A.; Wagstyl, K.; Bertolero, M.; Markello, R.; Pines, A.; Sydnor, V. J.; Diaz-Papkovich, A.; Hansen, J.; Evans, A. C.; Bernhardt, B.; Misic, B.; Satterthwaite, T.; Seidlitz, J.
10.1101/2022.09.18.508425 — neuroscience — Posted on 2022-09-18
1880 Medial accumbens shell spiny projection neurons encode relative reward preference
Pedersen, C. E.; Castro, D. C.; Hjort, M. M.; Zhou, Z. C.; Piantadosi, S. C.; Gowrishankar, R.; Kan, S. A.; Murphy, P. J.; O'Neill, P. R.; Bruchas, M.
10.1101/2022.09.18.508426 — neuroscience — Posted on 2022-09-18
1889 Rapid protection of nonhuman primates against Marburg virus disease using a single low-dose VSV-based vaccine
O'Donnell, K. L.; Feldmann, F.; Kaza, B.; Clancy, C. S.; Hanley, P. W.; Fletcher, P.; Marzi, A.
10.1101/2022.09.17.508396 — immunology — Posted on 2022-09-18
1892 Robust eIF4B levels undermine invasive growth and immune evasion mechanisms in murine triple negative breast cancer models.
Smith, R.; Diba, L. Z. D. Z. D.; Srinivasan, A.; Zollo, R. A.; Ossevoort, T.; He, Q.; Colligan, S. H.; Dolan, M.; Vedire, Y.; Sultana, T.; Venkatesh, M.; Arora, A. P.; Gawlak, S.; Washington, D.; Brackett, C.; Yao, S.; Ebos, J. M. L.; Abrams, S. I.; Barbi, J.; Walker, S. E.
10.1101/2022.09.16.508318 — cancer biology — Posted on 2022-09-18
1894 Mediator Kinase Inhibition Impedes Transcriptional Plasticity and Prevents Resistance to ERK/MAPK-Targeted Therapy in KRAS-Mutant Cancers
Nussbaum, D. P.; Martz, C. A.; Waters, A. M.; Barrera, A.; Rutter, J. C.; Cerda-Smith, C. G.; Stewart, A. E.; Wu, C.; Cakir, M.; Levandowski, C. B.; Kantrowitz, D. E.; McCall, S. J.; Pierobon, M.; Petricoin, E.; Smith, J. J.; Reddy, T. E.; Der, C. J.; Taatjes, D. J.; Wood, K. C.
10.1101/2022.09.17.508384 — cancer biology — Posted on 2022-09-18
1895 Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltration
Tretter, C.; de Andrade Kraetzig, N.; Pecoraro, M.; Lange, S.; Seifert, P.; von Frankenberg, C.; Untch, J.; Dreyer, F. S.; Braeunlein, E.; Wilhelm, M.; Zolg, D. P.; Engleitner, T.; Uhrig, S.; Boxberg, M.; Steiger, K.; Slotta-Huspenina, J.; Ochsenreither, S.; von Bubnoff, N.; Bauer, S.; Boerries, M.; Jost, P. J.; Schenck, K.; Dresing, I.; Bassermann, F.; Friess, H.; Reim, D.; Gruetzmann, K.; Pfuetze, K.; Klink, B.; Schrock, E.; Haller, B.; Kuster, B.; Mann, M.; Weichert, W.; Froehling, S.; Rad, R.; Hiltensperger, M.; Krackhardt, A. M.
10.1101/2022.09.17.508207 — cancer biology — Posted on 2022-09-18
1897 Modularly designed protein fragments combine into thousands of active and structurally diverse enzymes
Lipsh-Sokolik, R.; Khersonsky, O.; Schroder, S. P.; de Boer, C.; Hoch, S. Y.; Davies, G. J.; Overkleeft, H. S.; Fleishman, S. J.
10.1101/2022.09.17.508230 — bioengineering — Posted on 2022-09-18
1898 Rigidified Scaffolds for 3-Angstrom Resolution Cryo-EM of Small Therapeutic Protein Targets
Castells-Graells, R.; Meador, K.; Arbing, M. A.; Sawaya, M. R.; Gee, M.; Cascio, D.; Gleave, E. S.; Debreczeni, J. E.; Breed, J.; Phillips, C.; Yeates, T. O.
10.1101/2022.09.18.508009 — biochemistry — Posted on 2022-09-18
1899 Synthesis of Long RNA with a Site-Specific Modification by Enzymatic Splint Ligation
Gamper, H.; McCormick, C.; Tavakoli, S.; Wanunu, M.; Rouhanifard, S. H.; Hou, Y.-M.
10.1101/2022.09.17.508400 — biochemistry — Posted on 2022-09-18
1902 Parallel multicopy-suppressor screens reveal convergent evolution of phage-encoded single gene lysis proteins
Adler, B. A.; Chamakura, K.; Carion, H.; Krog, J.; Deutschbauer, A. M.; Young, R. F.; Mutalik, V. K.; Arkin, A. P.
10.1101/2022.01.20.477139 — microbiology — Posted on 2022-09-18
1903 Phospholipase B is critical for Cryptococcus neoformans survival in the central nervous system
Hamed, M. F.; Araujo, G.; Munzen, M. E.; Reguera Gomez, M.; Epstein, C.; Lee, H. H.; frases, s.; Martinez, L. R.
10.1101/2022.09.18.508401 — microbiology — Posted on 2022-09-18
1904 A family of novel immune systems targets early infection of nucleus-forming jumbo phages
Li, Y.; Guan, J.; Hareendranath, S.; Crawford, E.; Agard, D. A.; Makarova, K. S.; Koonin, E. V.; Bondy-Denomy, J.
10.1101/2022.09.17.508391 — microbiology — Posted on 2022-09-18
1905 Using Biological Constraints to Improve Prediction in Precision Oncology
Omar, M.; Dinalankara, W.; Mulder, L.; Coady, T.; Zanettini, C.; Imada, E. L.; Younes, L.; Geman, D.; Marchionni, L.
10.1101/2021.05.25.445604 — bioinformatics — Posted on 2022-09-18
1912 Recording large-scale, cellular-resolution neuronal activity from freely-moving mice
Das, A.; Holden, S.; Borovicka, J.; Icardi, J.; Patel, D.; Patel, R.; Raber, J.; Dana, H.
10.1101/2022.06.01.494442 — neuroscience — Posted on 2022-09-18
1914 Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening.
Ramos, A.; Koch, C. E.; Liu, Y.; Hellinger, R. D.; Kyung, T.; Abbott, K. L.; Froese, J.; Goulet, D.; Gordon, K. S.; Larson, R. C.; Doench, J. G.; Regev, A.; Vander Heiden, M. G.; Maus, M. V.; Birnbaum, M. E.; Hemann, M.
10.1101/2022.02.15.480217 — cancer biology — Posted on 2022-09-18
1915 Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
Tejedor, A. R.; Sanchez-Burgos, I.; Estevez-Espinosa, M.; Garaizar, A.; Collepardo-Guevara, R.; Ramirez, J.; Espinosa, J. R.
10.1101/2022.03.30.486367 — biophysics — Posted on 2022-09-18
1918 A deep learning and digital archaeology approach for mosquito repellent discovery
Wei, J. N.; Vlot, M.; Sanchez-Lengeling, B.; Lee, B. K.; Berning, L.; Vos, M. W.; Henderson, R. W.; Qian, W. W.; Ando, D. M.; Groetsch, K. M.; Gerkin, R. C.; Wiltschko, A. B.; Dechering, K. J.
10.1101/2022.09.01.504601 — bioengineering — Posted on 2022-09-18
1919 Experimental and theoretical aspects of Golden Gate Assembly assays
Strzelecki, P.; Shpiruk, A.; Hoffmann, E.; Cech, G. M.; Kloska, A.; Hebraud, P.; Beyer, N.; Busi, F.; Grange, W.
10.1101/2022.09.09.507109 — molecular biology — Posted on 2022-09-18
1927 STAT1 is required to establish but not maintain IFNγ-induced transcriptional memory
Tehrani, S. S.; Mikulski, P.; Abdul-Zani, I.; Mata, J. F.; Siwek, W.; Jansen, L. E. T.
10.1101/2022.09.17.508285 — molecular biology — Posted on 2022-09-17
1928 The cingulo-opercular network is composed of two distinct sub-systems
Gratton, C.; Dworetsky, A.; Adeyemo, B.; Seitzman, B. A.; Smith, D. M.; Petersen, S. E.; Neta, M.
10.1101/2022.09.16.508254 — neuroscience — Posted on 2022-09-18
1929 Adaptive compensation of arcuate fasciculus lateralization in developmental dyslexia
Zhao, J.; Zhao, Y.; Song, Z.; Thiebaut de Schotten, M.; Altarelli, I.; Ramus, F.
10.1101/2022.09.16.508343 — neuroscience — Posted on 2022-09-18
1931 Antigenic characterisation of human monoclonal antibodies for therapeutic use against H7N9 avian influenza virus
Chang, P.; Lukosaityte, D.; Sealy, J. E.; Rijal, P.; Sadeyen, J.-R.; Bhat, S.; Crossley, S.; Daines, R.; Huang, K.-Y. A.; Townsend, A.; Iqbal, M.
10.1101/2022.09.16.508351 — microbiology — Posted on 2022-09-17
1936 Computational remodeling of an enzyme conformational landscape for altered substrate selectivity
St-Jacques, A. D.; Rodriguez, J. M.; Eason, M. G.; Foster, S. M.; Khan, S. T.; Damry, A. M.; Goto, N. K.; Thompson, M. C.; Chica, R. A.
10.1101/2022.09.16.508321 — biophysics — Posted on 2022-09-17
1938 Splicing-dependent transcriptional activation
Uriostegui-Arcos, M.; Mick, S. T.; Shi, Z.; Rahman, R.; Fiszbein, A.
10.1101/2022.09.16.508316 — molecular biology — Posted on 2022-09-17
1939 Chaperonin activity of Plasmodium prefoldin complex is essential to guard proteotoxic stress response and presents a new target for drug discovery
Shoaib, R.; Kumar, V.; Garg, S.; Saini, M.; Kumari, J.; Maurya, P.; Gupta, A.; Gupta, N.; Singh, H.; Verma, P.; Jain, R.; Biswas, S.; Behl, A.; Abid, M.; Singh, S.
10.1101/2022.09.17.508354 — molecular biology — Posted on 2022-09-17
1940 Global genomic analysis reveals the genetic origin and secondary invasion of fall armyworm in the Eastern hemisphere
Zhang, L.; Li, Z.; Peng, Y.; Liang, X.; Wilson, K.; Chipabika, G.; Schranz, M. E.; Ros, V. I. D.; van Velzen, R.; Xiao, Y.
10.1101/2022.09.16.508260 — molecular biology — Posted on 2022-09-17
1942 Thermophilic carboxylesterases from hydrothermal vents of the volcanic island of Ischia active on synthetic and biobased polymers and mycotoxins
Distaso, M. A.; Chernikova, T. N.; Bargiela, R.; Coscoln, C.; Stogios, P. J.; Gonzalez, J. L.; Lemak, S.; Khusnutdinova, A. N.; Plou, F. J.; Evdokimova, E.; Savchenko, A.; Lunev, E. A.; Yakimov, M. M.; Golyshina, O. V.; Ferrer, M.; Yakunin, A. F.; Golyshin, P. N.
10.1101/2022.09.17.508236 — microbiology — Posted on 2022-09-17
1943 Supervised Machine Learning Enables Geospatial Microbial Provenance
Bhattacharya, C.; Tierney, B. T.; Ryon, K. A.; Bhattacharyya, M.; Hastings, J. J. A.; Basu, S.; Bhattacharya, B.; Bagchi, D.; Mukherjee, S.; Wang, L.; Henaff, E. M.; Mason, C.
10.1101/2022.09.16.508347 — microbiology — Posted on 2022-09-17
1945 CD73 generated extracellular adenosine promotes resolution of neutrophil-mediated tissue injury and restrains metaplasia in pancreatitis
O'Brien, B. J.; Faraoni, E. Y.; Strickland, L. N.; Ma, Z.; Mota, V. Y.; Mota, S. Y.; Chen, X.; Mills, T.; Eltzschig, H. K.; DelGiorno, K. E.; Bailey-Lundberg, J. M.
10.1101/2022.09.17.508367 — immunology — Posted on 2022-09-17
1948 A second generation capture panel for cost-effective sequencing of genome regulatory regions in wheat and relatives
Zhang, J.; Debernardi, J. M.; Burguener, G.; Choulet, F.; Paux, E.; O'Connor, L.; Enk, J.; Dubcovsky, J.
10.1101/2022.09.16.508311 — genomics — Posted on 2022-09-17
1949 Genomic deletions and rearrangements in monkeypox virus from the 2022 outbreak, USA
Gigante, C. M.; Plumb, M.; Ruprecht, A.; Zhao, H.; Wicker, V.; Wilkins, K.; Matheny, A.; Khan, T.; Davidson, W.; Sheth, M.; Burgin, A.; Burroughs, M.; Padilla, J.; Lee, J. S.; Dhwani, B.; Hetrick, E. E.; Howard, D. T.; Garfin, J.; Tate, L.; Hubsmith, S. J.; Mendoza, R. M.; Stanek, D.; Gillani, S.; Lee, M.; Mangla, A.; Blythe, D.; Sierra-Patev, S.; Carpenter-Azevedo, K.; Huard, R. C.; Gallagher, G.; Hall, J.; Ash, S.; Kovar, L.; Seabolt, M. H.; Weigand, M. R.; Damon, I.; Satheshkumar, P. S.; McCollum, A. M.; Hutson, C. L.; Wang, X.; Li, Y.
10.1101/2022.09.16.508251 — genomics — Posted on 2022-09-17
1954 Shared and distinct genetic etiologies for different types of clonal hematopoiesis
Brown, D. W.; Cato, L. D.; Zhao, Y.; Nandakumar, S. K.; Bao, E. L.; Gardner, E.; DePaulis, A.; Rehling, T.; Song, L.; Yu, K.; Chanock, S. J.; Perry, J. R. B.; Sankaran, V. G.; Machiela, M. J.
10.1101/2022.03.14.483644 — genetics — Posted on 2022-09-17
1960 Small protein modules dictate prophage fates during polylysogeny
Silpe, J. E.; Duddy, O. P.; Hussain, F. A.; Forsberg, K. J.; Bassler, B. L.
10.1101/2022.09.16.508337 — microbiology — Posted on 2022-09-17
1962 Common insecticide affects spatial navigation in bats at environmentally-realistic doses
Herrera, N. I. S.; Jacobo, L. L.; Soto, J. S. V.; Simmons, D.; Faure, P. A.; Welch, K. C.
10.1101/2022.09.14.508021 — pharmacology and toxicology — Posted on 2022-09-17
1963 Cancer cells communicate with macrophages to prevent T cell activation during development of cell cycle therapy resistance
Griffiths, J. I.; Cosgrove, P. A.; Medina Castaneda, E.; Nath, A.; Chen, J.; Adler, F. R.; Chang, J. T.; Khan, Q. J.; Bild, A. H.
10.1101/2022.09.14.507931 — cancer biology — Posted on 2022-09-17
1964 Poly-omic risk scores predict inflammatory bowel disease diagnosis
Arehart, C. H.; Sterrett, J. D.; Garris, R. L.; Quispe-Pilco, R. E.; Gignoux, C. R.; Evans, L. M.; Stanislawski, M. A.
10.1101/2022.09.14.508056 — bioinformatics — Posted on 2022-09-17
1965 Rapid and fully automated blood vasculature analysis in 3D light-sheet image volumes of different organs
Spangenberg, P.; Hagemann, N.; Squire, A.; Foerster, N.; Krauss, S. D.; Qi, Y.; yusuf, A. M.; Wang, J.; Grueneboom, A.; Kowitz, L.; Korste, S.; Totzeck, M.; Cibir, Z.; Tuz, A. A.; Singh, V.; Siemes, D.; Struensee, L.; Engel, D. R.; Ludewig, P.; Melo, L. M. N.; Helfrich, I.; Chen, J.; Gunzer, M.; Hermann, D. M.; Mosig, A.
10.1101/2022.09.14.507895 — bioinformatics — Posted on 2022-09-17
1969 Ancient DNA Reveals China as a Historical Genetic Melting Pot in Tiger Evolution
Sun, X.; Liu, Y.-C.; Tiunov, M. P.; Gimranov, D. O.; Zhuang, Y.; Han, Y.; Driscoll, C. A.; Pang, Y.-H.; Li, C.; Pan, Y.; Velasco, M. S.; Gopalakrishnan, S.; Yang, R.-Z.; Li, B.-G.; Jin, K.; Xu, X.; Uphyrkina, O.; Huang, Y.-Y.; Wu, X.-H.; Gilbert, M. T. P.; O'Brien, S. J.; Yamaguchi, N.; Luo, S.-J.
10.1101/2022.09.14.507899 — evolutionary biology — Posted on 2022-09-17
1971 Sustainable reference points for multispecies coral reef fisheries
Mason, J. Z.; Cinner, J. E.; MacNeil, M. A.; Graham, N. A.; Hoey, A.; Beger, M.; Brooks, A.; Booth, D.; Edgar, G.; Feary, D.; Ferse, S.; Friedlander, A.; Gough, C.; Green, A.; Mouillot, D.; Polunin, N.; Stuart-Smith, R.; Wantiez, L.; Williams, I.; Wilson, S.; Connolly, S. R.
10.1101/2022.09.14.508013 — ecology — Posted on 2022-09-17
1973 intSDM: A reproducible framework for integrated species distribution models
Mostert, P. S.; Bjorkas, R.; Bruls, A. J. H. M.; Koch, W.; Martin, E. C.
10.1101/2022.09.15.507996 — ecology — Posted on 2022-09-17
1974 Epidermal maintenance of Langerhans cells relies on autophagy-regulated lipid metabolism
Arbogast, F.; Sal-Carro, R.; Boufenghour, W.; Frenger, Q.; Bouis, D.; Filippi de la Palavesa, L.; Fauny, J.-D.; Griso, O.; Puccio, H.; Fima, R.; Huby, T.; Gautier, E. L.; Molitor, A.; Carapito, R.; Bahram, S.; Romani, N.; Clausen, B. E.; Voisin, B.; Mueller, C. G.; Gros, F.; Flacher, V.
10.1101/2022.09.16.507799 — immunology — Posted on 2022-09-17
1976 Hippocampal damage causes retrograde amnesia for objects' visual, but not odour, properties
Lacoursiere, S. G.; McAllister, B. B.; Hadikin, C.; Tschetter, W. W.; Lehmann, H.; Sutherland, R. J.
10.1101/2022.09.14.508050 — neuroscience — Posted on 2022-09-17
1977 Detection of neuronal OFF periods as low amplitude neural activity segments
Harding, C. D.; Guillaumin, M. C. C.; Krone, L. B.; Kahn, M. C.; Blanco-Duque, C.; Mikutta, C.; Vyazovskiy, V. V.
10.1101/2022.09.16.508135 — neuroscience — Posted on 2022-09-17
1981 Parvalbumin protein controls inhibitory tone in the spinal cord
Qiu, H.; Miraucourt, L.; Petitjean, H.; Davidova, A.; Levesque-Damphousse, P.; Estall, J. L.; Sharif-Naeini, R.
10.1101/2022.09.15.508019 — neuroscience — Posted on 2022-09-17
1984 Brain glucose metabolism and ageing: A 5-year longitudinal study in a large PET cohort
Pak, K.; Malen, T.; Santavirta, S.; Shin, S.; Nam, H. Y.; De Maeyer, S.; Nummenmaa, L.
10.1101/2022.09.15.508088 — neuroscience — Posted on 2022-09-17
1987 The magnitude of sex differences in host-microbe interactions are time-of-day dependent
Munyoki, S. K.; Goff, J. P.; Mullett, S. J.; Burns, J. K.; Jenkins, A. K.; DePoy, L. M.; Wendell, S. G.; McClung, C. A.; Morrison, K. E.; Jasarevic, E.
10.1101/2022.09.15.508006 — systems biology — Posted on 2022-09-17
1990 Dehydration alters transcript levels in the midgut, likely facilitating rapid rehydration
Holmes, C. J.; Brown, E. S.; Sharma, D.; Warden, M.; Pathak, A.; Payton, B.; Nguyen, Q.; Spangler, A.; Sivakumar, J.; Hendershot, J. M.; Benoit, J. B.
10.1101/2022.09.15.508146 — physiology — Posted on 2022-09-17
1994 Dimethyl fumarate modulates the Duchenne muscular dystrophy disease program following short-term treatment in mdx mice
Timpani, C. A.; Kourakis, S.; Debruin, D. A.; Campelj, D. G.; Pompeani, N.; Dargahi, N.; Bautista, A. P.; Bagaric, R. M.; Ritenis, E. J.; Sahakian, L.; Hafner, P.; Arthur, P. G.; Terrill, J. R.; Apostolopoulos, V.; de Haan, J. B.; Guven, N.; Fischer, D.; Rybalka, E.
10.1101/2022.09.15.508124 — pathology — Posted on 2022-09-17
1996 Melanoma-intrinsic NR2F6 activity regulates anti-tumor immunity
Kim, H.; Feng, Y.; Murad, R.; Klepsch, V.; Baier, G.; Ronai, Z. A.
10.1101/2022.09.14.508028 — cancer biology — Posted on 2022-09-17
1997 Illuminating histidine phosphorylation in the pancreatic tumor microenvironment
Hunter, T.; Wahl, G.; Lytle, N.; DelGiorno, K. E.; Shi, Y.; Kaech, S.; Naeem, R.; Luhtala, N.; Hollingsworth, M.
10.1101/2022.09.15.508158 — cancer biology — Posted on 2022-09-17
2000 Genetically encoded non-canonical amino acids reveal asynchronous dark reversion of chromophore, backbone and side-chains in EL222
Chaudhari, A. S.; Chatterjee, A.; Domingos, C. A. O.; Andrikopoulos, P. C.; Liu, Y.; Andersson, I.; Schneider, B.; Lorenz-Fonfria, V. A.; Fuertes, G.
10.1101/2022.09.16.506679 — biophysics — Posted on 2022-09-17
2001 ReproTox-KG: Toxicology Knowledge Graph for Structural Birth Defects
Evangelista, J. E.; Clarke, D. J.; Xie, Z.; Marino, G. B.; Utti, V.; Ahooyi, T. M.; Jenkins, S. L.; Taylor, D.; Bologa, C. G.; Yang, J. J.; Binder, J. L.; Kumar, P.; Lambert, C. G.; Grethe, J. S.; Wenger, E.; Oprea, T. I.; de Bono, B.; Ma'ayan, A.
10.1101/2022.09.15.508198 — bioinformatics — Posted on 2022-09-17
2010 Adaptive Optical Coherent Raman Imaging of Axons through Mouse Cranial Bone
Lim, J. M.; Yoon, S.; Kim, S.; Choi, Y.; Hong, J. H.; Choi, W.; Cho, M.
10.1101/2022.09.14.507912 — bioengineering — Posted on 2022-09-17
2011 The maize pathogen Ustilago maydis secretes glycoside hydrolases and carbohydrate oxidases directed towards components of the fungal cell wall
Bissaro, B.; Berrin, J.-G.; Grisel, S.; Reyre, J.-L.; Haon, M.; Navarro, D.; Ropartz, D.; Le Gall, S.; Record, E.; Sciara, G.; Tranquet, O.
10.1101/2022.09.16.508353 — biochemistry — Posted on 2022-09-17
2012 Chronic Gq activation of ventral hippocampal neurons and astrocytes differentially affects memory and behavior
Suthard, R. L.; Jellinger, A. L.; Shpokayte, M.; Surets, M.; Pyo, A. Y.; Buzharsky, M. D.; Senne, R. A.; LeBlanc, H.; Ramirez, S.
10.1101/2022.09.15.508157 — animal behavior and cognition — Posted on 2022-09-17
2014 RECOMBINATION HOTSPOTS IN SOYBEAN
McConaughy, S.; Amundsen, K.; Song, Q.; Pantalone, V.; Hyten, D.
10.1101/2022.09.15.508170 — genetics — Posted on 2022-09-17
2015 Visual-motor integration deficits in 3q29 deletion syndrome
Pollak, R. M.; Burrell, T. L.; Cubells, J. F.; Klaiman, C.; Murphy, M. M.; Saulnier, C. A.; Walker, E. F.; White, S. P.; Mulle, J. G.
10.1101/2022.09.15.508134 — genetics — Posted on 2022-09-17
2018 Geological drivers of diversification in Papuan microhylid frogs
Hill, E. C.; Gao, D. F.; Polhemus, D. A.; Fraser, C. J.; Iova, B.; Allison, A.; Butler, M. A.
10.1101/2022.09.15.508064 — evolutionary biology — Posted on 2022-09-17
2021 A biophysical model of viral escape from polyclonal antibodies
Yu, T. C.; Thornton, Z. T.; Hannon, W. H.; DeWitt, W. S.; Radford, C. E.; Matsen, F. A.; Bloom, J. D.
10.1101/2022.09.17.508366 — evolutionary biology — Posted on 2022-09-17
2025 The environmental roots of the relationship between glucocorticoids and body mass in the wild
Lalande, L. D.; Gilot-Fromont, E.; Carbillet, J.; Debias, F.; Duhayer, J.; Gaillard, J.-M.; Lemaitre, J.-F.; Palme, R.; Pardonnet, S.; Pellerin, M.; Rey, B.; Vuarin, P.
10.1101/2022.09.15.508076 — ecology — Posted on 2022-09-17
2027 Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells
Klein, F.; Veiga-Villauriz, C.; Boersch, A.; Maio, S.; Palmer, S.; Zuklys, S.; Calvo-Asensio, I.; Musette, L.; Deadman, M. E.; Dhalla, F.; White, A.; Lucas, B.; Anderson, G.; Hollaender, G. A.
10.1101/2022.09.14.507949 — immunology — Posted on 2022-09-17
2030 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes
Schutzer, S. E.; Liu, T.; Tsai, C.-F.; Petyuk, V. A.; Schepmoes, A.; Wang, Y.-T.; Weitz, K.; Bergquist, J.; Smith, R.; Natelson, B.
10.1101/2022.09.14.506792 — neuroscience — Posted on 2022-09-17
2032 Improving 3D Edge Detection for Visual Inspection of MRI Coregistration and Alignment
Rorden, C.; Newman-Norlund, R.; Drake, C.; Glen, D. R.; Fridriksson, J.; Hanayik, T.; Taylor, P. A.
10.1101/2022.09.14.507937 — neuroscience — Posted on 2022-09-17
2035 Acute hyper- and hypoglycemia uncouples the metabolic cooperation between glucose and lactate to disrupt sleep
Carroll, C. M.; Stanley, M.; Raut, R. V.; Constantino, N. J.; Irmen, R. E.; Mitra, A.; Snipes, J. A.; Raichle, M. E.; Holtzman, D. M.; Gould, R. W.; Kishida, K. T.; Macauley, S. L.
10.1101/2022.09.15.507967 — neuroscience — Posted on 2022-09-17
2038 Cell-type-specific roles of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage
Kumar, M.; Handy, G.; Kouvaros, S.; Ljungqvist Brinson, L.; Bizup, B.; Doiron, B.; Tzounopoulos, T.
10.1101/2022.09.15.508128 — neuroscience — Posted on 2022-09-17
2040 Genetic Disruption of System xc- Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat
Hess, E. M.; Kassel, S. N.; Simandl, G.; Raddatz, N. J.; Hurley, M. M.; Grzybowski, M.; Klotz, J.; Geurts, A.; Liu, Q.-s.; Choi, S.; Twining, R. C.; Baker, D.
10.1101/2022.09.14.504799 — neuroscience — Posted on 2022-09-17
2042 Deficiency of Heterogeneous Nuclear Ribonucleoprotein U leads to delayed neurogenesis
Mastropasqua, F.; Oksanen, M.; Soldini, C.; Alatar, S.; Arora, A.; Ballarino, R.; Molinari, M.; Agostini, F.; Poulet, A.; Watts, M. E.; Rabkina, I.; Becker, M.; Li, D.; Anderlid, B.-M.; Isaksson, J.; Remnelius, K. L.; Moslem, M.; Jacob, Y.; Falk, A.; Crosetto, N.; Bienko, M.; Santini, E.; Borgkvist, A.; Bölte, S.; Tammimies, K.
10.1101/2022.09.14.507275 — neuroscience — Posted on 2022-09-17
2043 Efficient coding of natural images in the mouse visual cortex
Bolanos, F.; Orlandi, J. G.; Aoki, R.; Jagadeesh, A.; Gardner, J.; Benucci, A.
10.1101/2022.09.14.507893 — neuroscience — Posted on 2022-09-17
2045 Genetic loss of norepinephrine does not alter adult hippocampal neurogenesis in dopamine β-hydroxylase deficient mice
Kapri, D.; Vadodaria, K. C.; Rommelfanger, K. S.; Ogbonmwan, Y. E.; Liles, L. C.; Fernandes-Thomas, K. A.; Salvi, S. S.; Husain, B. F. A.; Weinshenker, D.; Vaidya, V. A.
10.1101/2022.09.14.508040 — neuroscience — Posted on 2022-09-17
2046 Translating DNA origami Nanotechnology to Middle School, High School, and Undergraduate Laboratories
Beshay, P. E.; Kucinic, A.; Wile, N.; Halley, P.; Des Rosiers, L.; Chowdhury, A.; Hall, J. L.; Castro, C. E.; Hudoba, M. W.
10.1101/2022.09.15.508130 — scientific communication and education — Posted on 2022-09-17
2047 The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice
Roussel, J.; LARCHER, R.; SICARD, P.; Bideaux, P.; RICHARD, S.; Thireau, J.; MARMIGERE, F.
10.1101/2022.09.14.507907 — physiology — Posted on 2022-09-17
2048 Quantitative bioactivity signatures of dietary supplements and natural products
Yasgar, A.; Bougie, D.; McKnight, C.; Miller, M.; Peryea, T.; Xia, M.; Shah, P.; Xu, X.; Shinn, P.; Itkin, M.; Lynch, C.; Zakharov, A. V.; Eastman, R.; Kouznetsova, J.; Ngan, D.; Huang, R.; Simeonov, A.
10.1101/2022.09.14.507630 — pharmacology and toxicology — Posted on 2022-09-17
2050 Revisiting the bad luck hypothesis: Cancer risk and aging are linked to replication-driven changes to the epigenome
Minteer, C. J.; Thrush, K.; Niimi, P.; Rozowsky, J.; Liu, J.; Frank, M.; McCabe, T.; Hofstatter, E.; Rozenblit, M.; Pusztai, L.; Beckman, K.; Gerstein, M.; Levine, M. E.
10.1101/2022.09.14.507975 — cancer biology — Posted on 2022-09-17
2051 ortho_seqs: A Python tool for sequence analysis and higher order sequence-phenotype mapping
Nafees, S.; Vemuri, V. N.; Woollacott, M.; Solak, A. C.; Logan, P.; McGeever, A.; Yoo, O.; Rice, S. H.
10.1101/2022.09.14.506443 — bioinformatics — Posted on 2022-09-17
2053 Dynamic Transcriptomic Network Responses to Divergent Acute Exercise Challenges in Young Adults
Lavin, K. M.; Graham, Z. A.; McAdam, J. S.; O'Bryan, S. M.; Drummer, D. J.; Bell, M. B.; Kelley, C. J.; Lixandrao, M. E.; Peoples, B.; Tuggle, S. C.; Seay, R.; Van Keuren-Jensen, K.; Huentelman, M. J.; Pirrotte, P.; Reiman, R.; Alsop, E.; Hutchins, E.; Antone, J.; Bonfitto, A.; Meechoovet, B.; Palade, J.; Talboom, J. S.; Sullivan, A.; Aban, I.; Peri, K.; Broderick, T. J.; Bamman, M. M.
10.1101/2022.09.14.507939 — bioinformatics — Posted on 2022-09-17
2057 Structural and functional changes of pyramidal neurons at the site of an implanted microelectrode array in rat primary motor cortex
Gregory, B. A.; Thompson, C. H.; Salatino, J. W.; Railing, M. J.; Zimmerman, A. F.; Gupta, B.; Williams, K.; Beatty, J. A.; Cox, C. L.; Purcell, E. K.
10.1101/2022.09.15.507997 — bioengineering — Posted on 2022-09-17
2059 Incorporation of bioactive peptides into peptide nanofibrillar hydrogels affects their nanostructure, mechanical properties and biocompatibility
Chong, C. J. H.; Charnley, M.; Ratcliffe, J.; Caballero-Aguilar, L. M.; Moulton, S. E.; Binger, K. J.; Reynolds, N. P.
10.1101/2022.09.15.508197 — bioengineering — Posted on 2022-09-17
2063 Genomic architecture of migration timing in a long-distance migratory songbird
de Greef, E.; Suh, A.; Thorstensen, M. J.; Delmore, K.; Fraser, K. C.
10.1101/2022.09.14.508039 — genomics — Posted on 2022-09-17
2066 Differential modularity of the mammalian Engrailed 1 enhancer network directs eccrine sweat gland development
Aldea, D.; Kokalari, B.; Atsuta, Y.; Dingwall, H. L.; Zheng, Y.; Nace, A.; Cotsarelis, G.; Kamberov, Y. G.
10.1101/2022.09.14.508033 — evolutionary biology — Posted on 2022-09-17
2067 The rapid radiation of Bomarea (Alstroemeriaceae: Liliales), driven by the rise of the Andes
Tribble, C. M.; Alzate-Guarin, F.; Gandara, E.; Vartoumian, A.; Burleigh, J. G.; Zenil-Ferguson, R.; Specht, C. D.; Rothfels, C. J.
10.1101/2022.09.15.507859 — evolutionary biology — Posted on 2022-09-17
2068 A continental scale analysis reveals widespread root bimodality
Lu, M.; Wang, S.; Malhotra, A.; Tumber-Davila, S. J.; Weintraub-Leff, S.; McCormack, L.; Wang, X. T.; Jackson, R. B.
10.1101/2022.09.14.507823 — ecology — Posted on 2022-09-17
2070 Collection of triatomines from sylvatic habitats by a Chagas-positive, trained scent-detection canine in Texas, USA
Christopher, D.; Curtis-Robles, R.; Hamer, G. L.; Bejcek, J.; Saunders, A.; Roachell, W.; Cropper, T. L.; Hamer, S. A.
10.1101/2022.09.14.508062 — ecology — Posted on 2022-09-17
2071 P3HT-GRAPHENE DEVICE FOR THE RESTORATION OF VISUAL PROPERTIES IN A RAT MODEL OF RETINITIS PIGMENTOSA
Francia, S.; DiMarco, S.; DiFrancesco, M. L.; Ferrari, D. V.; Shmal, D.; Cavalli, A.; Pertile, G.; Attanasio, M.; Maya-Vetencourt, J. F.; Manfredi, G.; Lanzani, G.; Benfenati, F.; Colombo, E.
10.1101/2022.09.14.507903 — neuroscience — Posted on 2022-09-17
2073 Non-invasive temporal interference electrical stimulation of the human hippocampus
Violante, I. R.; Alania, K.; Cassara, A. M.; Neufeld, E.; Acerbo, E.; Carron, R.; Williamson, A.; Kurtin, D. L.; Rhodes, E.; Hampshire, A.; Kuster, N.; Boyden, E. S.; Pascual-Leone, A.; Grossman, N.
10.1101/2022.09.14.507625 — neuroscience — Posted on 2022-09-17
2075 A genomic study of the Japanese population focusing on the glucocorticoid receptor interactome highlights distinct genetic characteristics associated with stress response
Mitsis, T.; Papageorgiou, L.; Papakonstantinou, E.; Diakou, I.; Pierouli, K.; Dragoumani, K.; Bacopoulou, F.; Kino, T.; Chrousos, G. P.; Eliopoulos, E.; Vlachakis, D.
10.1101/2022.09.16.508283 — bioinformatics — Posted on 2022-09-17
2082 Leishmania major centrin knock-out parasites alter the Kynurenine- aryl hydrocarbon receptor signaling to produce a pro-inflammatory response
Oljuskin, T.; Azodi, N.; Volpedo, G.; Bhattacharya, P.; Ismail, N.; Hamano, S.; Matlashewski, G.; Satoskar, A.; Gannavaram, S.; Nakhasi, H.
10.1101/2022.09.15.508117 — systems biology — Posted on 2022-09-17
2089 An R-R-type MYB transcription factor promotes nonclimacteric pepper fruit ripening pigmentation
Ning, Z.; Song, J.; Chen, C.; Sun, B.; Zhang, S.; Cai, Y.; Zheng, X.; Cao, B.; Chen, G.; Jin, D.; Li, B.; Bian, J.; Lei, J.; He, H.; Zhu, Z.
10.1101/2022.09.15.507774 — plant biology — Posted on 2022-09-17
2090 Brassinosteroid gene regulatory networks at cellular resolution
Nolan, T. M.; Vukasinovic, N.; Hsu, C.-W.; Zhang, J.; Vanhoutte, I.; Shahan, R.; Taylor, I. W.; Greenstreet, L.; Heitz, M.; Wang, P.; Szekely, P.; Brosnan, A.; Yin, Y.; Schiebinger, G.; Ohler, U.; Russinova, E.; Benfey, P. N.
10.1101/2022.09.16.508001 — plant biology — Posted on 2022-09-17
2092 An updated evolutionary and structural study of TBK1 reveals highly conserved motifs as potential pharmacological targets in neurodegenerative diseases.
Papageorgiou, L.; Mangana, E.; Papakonstantinou, E.; Diakou, I.; Pierouli, K.; Dragoumani, K.; Bacopoulou, F.; Chrousos, G. P.; Exarchos, T. P.; Vlamos, P.; Eliopoulos, E.; Vlachakis, D.
10.1101/2022.09.16.508274 — bioinformatics — Posted on 2022-09-17
2096 Rnf20 shapes the endothelial control of heart morphogenesis and function
Kessler, L.; Gao, R.; Tetik-Elsherbiny, N.; Lityagina, O.; Zhailauova, A.; Ren, Y.; Trogisch, F. A.; Cordero, J.; Dou, Y.; Wang, Y.; Chichelnitskiy, E.; Kraske, J.; Schaefer, P.; Wu, C.-C.; Barreto, G.; Potente, M.; Wieland, T.; Ola, R.; Heineke, J.; Dobreva, G.
10.1101/2022.09.16.508288 — developmental biology — Posted on 2022-09-17
2099 Hybridization led to a rewired pluripotency network in the allotetraploid Xenopus laevis
Phelps, W. A.; Hurton, M. D.; Ayers, T. N.; Carlson, A. E.; Rosenbaum, J. C.; Lee, M. T.
10.1101/2022.09.14.507817 — developmental biology — Posted on 2022-09-17
2101 Large scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal crosstalk
Yu, L.; Ezashi, T.; Wei, Y.; Duan, J.; Logsdon, D.; Zhan, L.; Nahar, A.; Arteaga, C. P.; Liu, L.; Stobbe, C.; Katz-Jaffe, M.; Schoolcraft, W. B.; Wang, L.; Tan, T.; Hon, G. C.; Yuan, Y.; Wu, J.
10.1101/2022.09.14.507946 — developmental biology — Posted on 2022-09-17
2104 Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds
Swift, S. K.; Purdy, A. L.; Kolell, M. E.; Flinn, M. A.; Lahue, C.; Buddell, T.; Akins, K. A.; Foster, P.; O'Meara, C. C.; Rau, C.; Patterson, M.
10.1101/2022.09.15.508152 — developmental biology — Posted on 2022-09-17
2106 Toward Improving Immunotolerance for Stem Cell-Derived Islets
Zhou, Q.; Li, H.; Gerace, D.; Nikolskly, I.; Wang, X.; Kenty-Ryu, J.; Zhang, J.; Hinderhofer, M.; Robinson, E.; Melton, D. A.
10.1101/2022.09.15.508091 — developmental biology — Posted on 2022-09-17
2107 Neuroprotective tissue adaptation induced by IL-12 attenuates CNS inflammation
Andreadou, M.; Ingelfinger, F.; De Feo, D.; Friebel, E.; Tuzlak, S.; Cramer, T. M. L.; Schreiner, B.; Eede, P.; Schneeberger, S.; Geesdorf, M.; Ridder, F.; Welsh, C. A.; Kirschenbaum, D.; Tyagarajan, S. K.; Greter, M.; Heppner, F. L.; Mundt, S.; Becher, B.
10.1101/2022.09.14.506749 — immunology — Posted on 2022-09-16
2108 Direct inference and control of genetic population structure from RNA sequencing data
Fachrul, M.; Karkey, A.; Shakya, M.; Judd, L.; Harshegyi, T.; Sim, K. S.; Tonks, S.; Dongol, S.; Shrestha, R.; Salim, A.; STRATAA study group, ; Baker, S.; Pollard, A. J.; Khor, C. C.; Dolecek, C.; Basnyat, B.; Dunstan, S. J.; Holt, K. E.; Inouye, M.
10.1101/2022.09.16.508259 — bioinformatics — Posted on 2022-09-16
2109 Mitochondrial sodium/calcium exchanger NCLX regulates glycolysis in astrocytes, impacting on cognitive performance
Cabral-Costa, J. V.; Vicente-Gutierrez, C.; Agulla, J.; Lapresa, R.; Elrod, J. W.; Almeida, A.; Bolanos, J. P.; Kowaltowski, A. J.
10.1101/2022.09.16.507284 — biochemistry — Posted on 2022-09-16
2111 Notch directs telencephalic development and neuron fate determination by regulating miRNA levels
Han, J. S.; Fishman-Williams, E. K.; Decker, S. C.; Hino, K. K.; Reyes, R. V.; Brown, N. L.; Simo, S.; La Torre, A.
10.1101/2022.09.16.508220 — developmental biology — Posted on 2022-09-16
2112 Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation
Theobald, H.; Bejarano, D.; Katzmarski, N.; Haub, J.; Schulte-Schrepping, J.; Yu, J.; Bassler, K.; Osei-Sarpong, C.; Piattini, F.; Vornholz, L.; Xu, X.; Sheoran, S.; Al Jawazneh, A.; Chakarov, S.; Haendler, K.; Brown, G. D.; Williams, D.; Bosurgi, L.; Ginhoux, F.; Ruland, J.; Beyer, M. D.; Greter, M.; Kopf, M.; Schultze, J. L.; Schlitzer, A.
10.1101/2022.09.15.505390 — immunology — Posted on 2022-09-16
2113 Feature similarity gradients detect alterations in the neonatal cortex associated with preterm birth
Galdi, P.; Blesa Cabez, M.; Farrugia, C.; Vaher, K.; Williams, L. Z. J.; Sullivan, G.; Stoye, D. Q.; Quigley, A. J.; Makropoulos, A.; Thrippleton, M. J.; Bastin, M. E.; Richardson, H.; Whalley, H. C.; Edwards, D.; Bajada, C. J.; Robinson, E. C.; Boardman, J. P.
10.1101/2022.09.15.508133 — neuroscience — Posted on 2022-09-16
2114 Advanced Feedback Enhances Sensorimotor Adaptation
Wang, T.; Avraham, G.; Tsay, J.; Thummala, T.; Ivry, R. B.
10.1101/2022.09.14.508027 — neuroscience — Posted on 2022-09-16
2115 Antiviral effect of thiazolides relies on mitochondrial mild uncoupling
Hammad, N.; Ransy, C.; Pinson, B.; Talmasson, J.; Brechot, C.; Bouillaud, F.; Rossignol, J.-F.
10.1101/2022.09.16.508272 — biochemistry — Posted on 2022-09-16
2117 Characterizing the Resolution and Throughput of the Apollo Direct Electron Detector
Peng, R.; Fu, X.; Mendez, J. H.; Randolph, P. S.; Bammes, B. E.; Stagg, S. M.
10.1101/2022.09.16.508245 — biochemistry — Posted on 2022-09-16
2119 Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin.
Paranjpe, M. N.; Marina, V. I.; Grachev, A. A.; Maviza, T. P.; Tolicheva, O. A.; Paleskava, A.; Osterman, I. A.; Sergiev, P. V.; Konevega, A. L.; Polikanov, Y. S.; Gagnon, M. G.
10.1101/2022.09.15.508020 — molecular biology — Posted on 2022-09-16
2120 CTCF and R-loops are boundaries of cohesin-mediated DNA looping
Zhang, H.; Shi, Z.; Kim, Y.; Yu, H.; Bai, X.-c.; Finkelstein, I. J.
10.1101/2022.09.15.508177 — molecular biology — Posted on 2022-09-16
2121 Intermittent fasting has a diet-specific impact on the gut microbiota and colonic mucin O-glycosylation of mice
Gamage, H. K. A. H.; Sathili, A. M. M.; Nishtala, K.; Chong, R. W. W.; Packer, N. H.; Paulsen, I. T.
10.1101/2022.09.15.508181 — microbiology — Posted on 2022-09-16
2122 Molecular Acclimation of Halobacterium salinarum to Halite Brine Inclusions
Favreau, C.; Tribondeau, A.; Marugan, M.; Guyot, F.; Alpha-Bazin, B.; Marie, A.; Puppo, R.; Dufour, T.; Huguet, A.; Zirah, S.; Kish, A.
10.1101/2022.09.16.508090 — microbiology — Posted on 2022-09-16
2123 Production and characterisation of stabilised PV-3 virus-like particles using Pichia pastoris
Sherry, L.; Grehan, K.; Swanson, J. J.; Bahar, M. W.; Porta, C.; Fry, E. E.; Stuart, D. I.; Rowlands, D.; Stonehouse, N. J.
10.1101/2022.09.16.508282 — microbiology — Posted on 2022-09-16
2126 Semantic and population analysis of the genetic targets related to COVID-19 and its association with genes and diseases
Papageorgiou, L.; Papakonstantinou, E.; Diakou, I.; Pierouli, K.; Dragoumani, K.; Bacopoulou, F.; Chrousos, G. P.; Eliopoulos, E.; Vlachakis, D.
10.1101/2022.09.16.508278 — bioinformatics — Posted on 2022-09-16
2130 Leishmania mexicana Centrin Knock out Parasites Promote M1-polarizing Metabolic Changes
Volpedo, G.; Oljuskin, T.; Azodi, N.; Hamano, S.; Matlashewski, G.; Gannavaram, S.; Nakhasi, H.; Satoskar, A. R.
10.1101/2022.09.16.508215 — microbiology — Posted on 2022-09-16
2133 Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies
Sheward, D. J.; Kim, C.; Fischbach, J.; Muschiol, S.; Ehling, R. A.; Björkström, N. K.; Karlsson Hedestam, G. B.; Reddy, S. T.; Albert, J.; Peacock, T. P.; Murrell, B.
10.1101/2022.09.16.508299 — immunology — Posted on 2022-09-16
2135 Sumoylation is largely dispensable for normal growth but facilitates heat tolerance in yeast
Moallem, M.; Akhter, A.; Burke, G. L.; Babu, J.; Bergey, B. G.; McNeil, J. B.; Baig, M. S.; Rosonina, E.
10.1101/761759 — molecular biology — Posted on 2022-09-16
2136 Genome characterization of monkeypox cases detected in India: Identification of three sub clusters among A.2 lineage
Shete, A. M.; Yadav, P. D.; Kumar, A.; Patil, S.; Patil, D. Y.; Joshi, Y.; Majumdar, T.; Relhan, V.; Sahay, R. R.; Vasu, M.; Gawande, P.; Verma, A.; Kumar, A.; Dhakad, S.; Krishnan, A. B.; Chenayil, S.; Kumar, S.; Abraham, P.
10.1101/2022.09.16.507742 — microbiology — Posted on 2022-09-16
2137 SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF
Christ, W.; Kapell, S.; Mermelekas, G.; Evertsson, B.; Sork, H.; Bazaz, S.; Gustafsson, O.; Sobkowiak, M. J.; Cardenas, E. I.; Villa, V.; Ricciarelli, R.; Sandberg, J. K.; Bergquist, J.; Sturchio, A.; Svenningsson, P.; Malm, T.; Espay, A. J.; Pernemalm, M.; Linden, A.; Klingstrom, J.; EL Andaloussi, S.; Ezzat, K.
10.1101/2022.09.15.508120 — microbiology — Posted on 2022-09-16
2138 Imprinted SARS-CoV-2 humoral immunity induces converging Omicron RBD evolution
Cao, Y.; Jian, F.; Wang, J.; Yu, Y.; Song, W.; Yisimayi, A.; Wang, J.; An, R.; Zhang, N.; Wang, Y.; Wang, P.; Zhao, L.; Sun, H.; Yu, L.; Yang, S.; Niu, X.; Xiao, T.; Gu, Q.; Shao, F.; Hao, X.; Xu, Y.; Jin, R.; Wang, Y.; Xie, X. S.
10.1101/2022.09.15.507787 — immunology — Posted on 2022-09-16
2140 Genotypic sex shapes maternal care in the African Pygmy mouse, Mus minutoides
Heitzmann, L. D.; Challe, M.; Perez, J.; Castell, L.; Galibert, E.; Martin, A.; Valjent, E.; Veyrunes, F.
10.1101/2022.04.05.487174 — evolutionary biology — Posted on 2022-09-16
2141 Body mass change over winter is consistently sex-specific across roe deer populations
Hewison, A. J. M.; Bonnot, N.; Gaillard, J.-M.; Kjellander, P.; Lemaitre, J.-F.; Morellet, N.; Pellerin, M.
10.1101/2022.09.09.507329 — ecology — Posted on 2022-09-16
2143 Origins of monkeypox viruses and their strains circulating in 2022
Chen, J.-M.; Gong, H.; Chen, R.-X.; Sun, M.-H.; Yufei, J.; Li, G.-H.; Tan, S.-M.; Sun, Y.-X.
10.1101/2022.09.07.506685 — microbiology — Posted on 2022-09-16
2145 Immune, endothelial and neuronal network map in human lymph node and spleen
Currlin, S.; Nick, H.; Jorgensen, M.; Nick, J.; Brusko, M.; Hakimian, H.; Penaloza-Aponte, J.; Rodriguez, N.; Medina-Serpas, M.; Yang, M.; Seifert, R.; Kusmartseva, I.; Brusko, T.; Otto, K.; Posgai, A.; Wasserfall, C.; Atkinson, M. A.
10.1101/2021.10.20.465151 — immunology — Posted on 2022-09-16
2147 Planar aggregation of the influenza viral fusion peptide alters membrane structure and hydration, promoting poration.
Rice, A.; Haldar, S.; Wang, E.; Blank, P. S.; Akimov, S. A.; Galimzyanov, T. R.; Pastor, R. W.; Zimmerberg, J.
10.1101/2021.08.09.455689 — biophysics — Posted on 2022-09-16
2149 OpenPBTA: An Open Pediatric Brain Tumor Atlas
Shapiro, J. A.; Gaonkar, K. S.; Savonen, C. L.; Spielman, S. J.; Bethell, C. J.; Jin, R.; Rathi, K. S.; Zhu, Y.; Egolf, L. E.; Farrow, B. K.; Miller, D. P.; Yang, Y.; Koganti, T.; Noureen, N.; Koptyra, M. P.; Duong, N.; Kraya, A. A.; Kline, C. N.; Guo, Y.; Storm, P. B.; Nazarian, J.; Mack, S. C.; Raman, P.; Zheng, S.; Madsen, P. J.; Van Kuren, N.; Robins, S.; Huang, X.; Waanders, A. J.; Kim, J.; Hanson, D.; Koschmann, C. J.; Diskin, S. J.; Lulla, R. R.; Brown, M. A.; Wong, J.; Mason, J. L.; Scolaro, L.; Kim, M. C.; Xie, H. M.; Rood, B. R.; Cole, K. A.; Margol, A. S.; Vaksman, Z.; Kaufman, R. S
10.1101/2022.09.13.507832 — genomics — Posted on 2022-09-16
2150 Regenerative hallmarks of aging: Insights through the lens of Pleurodeles waltl
Tsissios, G.; Theodoroudis-Rapp, G.; Chen, W.; Sallese, A.; Smucker, B.; Ernst, L.; Chen, J.; Xu, Y.; Ratvasky, S.; Wang, H.; Del Rio-Tsonis, K.
10.1101/2022.09.13.507508 — developmental biology — Posted on 2022-09-16
2151 The human placenta shapes the phenotype of decidual macrophages.
Vondra, S.; Hoebler, A.-L.; Lackner, A. I.; Raffetseder, J.; Mihalic, Z. N.; Vogel, A.; Saleh, L.; Kunihs, V.; Haslinger, P.; Wahrmann, M.; Husslein, H.; Oberle, R.; Kargl, J.; Haider, S.; Latos, P.; Schabbauer, G.; Knoefler, M.; Ernerudh, J.; Pollheimer, J.
10.1101/2022.03.29.486171 — immunology — Posted on 2022-09-16
2152 Chronic stress exposure alters the gut barrier: sex-specific effects on microbiota and jejunum tight junctions
Doney, E.; Dion-Albert, L.; Coulombe-Rozon, F.; Osbourne, N.; Bernatchez, R.; Paton, S. E. J.; Kaufmann, F. N.; Agomma, R. O.; Solano, J. L.; Gaumond, R.; Dudek, K. A.; Szyszkowicz, J. K.; Signature Consortium, ; Lebel, M.; Doyen, A.; Durand, A.; Lavoie-Cardinal, F.; Audet, M.-C.; Menard, C.
10.1101/2022.09.13.507821 — neuroscience — Posted on 2022-09-16
2154 Coherently Remapping Toroidal Cells But Not Grid Cells are Responsible for Path Integration in Virtual Agents
Schoyen, V. S.; Pettersen, M. B.; Holzhausen, K.; Fyhn, M.; Malthe-Sorenssen, A.; Lepperod, M. E.
10.1101/2022.08.18.504379 — neuroscience — Posted on 2022-09-16
2157 Reconstituted depolarization-induced Ca2+ release platform for skeletal muscle disease mutation validation and drug discovery
Murayama, T.; Kurebayashi, N.; Numaga-Tomita, T.; Kobayashi, T.; Okazaki, S.; Yamashiro, K.; Nakada, T.; Mori, S.; Ishida, R.; Kagechika, H.; Yamada, M.; Sakurai, T.
10.1101/2022.06.29.498090 — physiology — Posted on 2022-09-16
2160 Seq2Neo: a comprehensive pipeline for cancer neoantigen im-munogenicity prediction
Diao, K.; Chen, J.; Wu, T.; Wang, X.; Wang, G.; Sun, X.; Zhao, X.; Wu, C.; Wang, J.; Yao, H.; Gerarduzzi, C.; Liu, X.-S.
10.1101/2022.09.14.507872 — bioinformatics — Posted on 2022-09-16
2161 Stretch-Induced Uncrimping of Equatorial Sclera Collagen Bundles
Jan, N.-J.; Lee, P.-Y.; Wallace, J.; Iasella, M.; Gogola, A.; Sigal, I. A.
10.1101/2022.09.13.507860 — bioengineering — Posted on 2022-09-16
2163 Sounding the alarm: sex differences in rat ultrasonic vocalizations during Pavlovian fear conditioning and extinction
Laine, M. A.; Mitchell, J. R.; Rhyner, J.; Clark, R.; Kannan, A.; Keith, J.; Pikus, M.; Bergeron, E.; Ravaglia, I.; Ulgenturk, E.; Shinde, A.; Shansky, R. M.
10.1101/2022.09.13.507801 — animal behavior and cognition — Posted on 2022-09-16
2164 A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus
Chinnaiya, K.; Burbridge, S.; Jones, A.; Kim, D. W.; Place, E.; Manning, E.; Groves, I.; Sun, C.; Towers, M.; Blackshaw, S.; Placzek, M.
10.1101/2022.08.31.506043 — developmental biology — Posted on 2022-09-16
2166 Experimental and theoretical aspects of Golden Gate Assembly assays
Strzelecki, P.; Shpiruk, A.; Hoffmann, E.; Cech, G. M.; Kloska, A.; Hebraud, P.; Beyer, N.; Busi, F.; Grange, W.
10.1101/2022.09.09.507109 — molecular biology — Posted on 2022-09-16
2167 Redox-based sensing controls bacterial chemotaxis to copper
Louis, G.; Cherry, P.; Michaux, C.; Rahuel-Clermont, S.; Dieu, M.; Tilquin, F.; Maertens, L.; Van Houdt, R.; Renard, P.; Perpete, E.; Matroule, J.-Y.
10.1101/2022.06.29.497744 — microbiology — Posted on 2022-09-16
2168 A Practical Alzheimer Disease Classifier via Brain Imaging-Based Deep Learning on 85,721 Samples
Lu, B.; Li, H.-X.; Chang, Z.-K.; Li, L.; Chen, N.-X.; Zhu, Z.-C.; Zhou, H.-X.; Li, X.-Y.; Wang, Y.-W.; Cui, S.-X.; Deng, Z.-Y.; Fan, Z.; Yang, H.; Chen, X.; Thompson, P. M.; Castellanos, F. X.; Yan, C.-G.
10.1101/2020.08.18.256594 — neuroscience — Posted on 2022-09-16
2170 The transcriptional and epigenetic reprogramming mediated by chronic IL1β exposure drives self-renewal ability and myeloid priming in TET2 deficient stem and progenitor cells.
McClatchy, J.; Strogantsev, R.; Wolfe, E.; Estabrook, J.; Lin, H.-Y.; Mohammadhosseini, M.; Davis, B.; Eden, C.; Goldman, D.; Fleming, W.; Cimmino, L.; Mohammed, H.; Agarwal, A.
10.1101/2022.09.15.507688 — cancer biology — Posted on 2022-09-16
2173 Developmental changes of opsin gene expression in ray-finned fishes (Actinopterygii)
Lupse, N.; Kłodawska, M.; Truhlárova, V.; Kosatko, P.; Kaspar, V.; Bitja Nyom, A. R.; Musilova, Z.
10.1101/2022.04.28.489877 — evolutionary biology — Posted on 2022-09-16
2174 O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Contribute to the Mutational Trajectory in Variants of Concern
Gonzalez-Rodriguez, E.; Zol-Hanlon, M.; Bineva-Todd, G.; Marchesi, A.; Skehel, M.; Mahoney, K.; Roustan, C.; Borg, A.; Di Vagno, L.; Kjaer, S.; Wrobel, A. G.; Benton, D. J.; Nawrath, P.; Flitsch, S. L.; Joshi, D.; Gonzalez-Ramirez, A. M.; Wilkinson, K. A.; Wilkinson, R. J.; Hurtado-Guerrero, R.; Malaker, S. A.; Schumann, B.
10.1101/2022.09.15.508093 — cell biology — Posted on 2022-09-16
2175 Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation
Shah, V.; Giotopoulos, G.; Osaki, H.; Meyerhoefer, M.; Meduri, E.; Schubert, B.; Yun, H.; Horton, S. J.; Agrawal-Singh, S.; Haehnel, P. S.; Basheer, F.; Lugo, D.; Kuehn, M. W.; Guezguez, B.; Theobald, M.; Kindler, T.; Gallipoli, P.; Prinjha, R. K.; Huntly, B. J.; Sasca, D.
10.1101/2022.09.14.507850 — cancer biology — Posted on 2022-09-16
2176 Single cell spatial analysis identifies regulators of brain tumor initiating cells
Mirzaei, R.; D'Mello, C.; Liu, M.; Nikolic, A.; Kumar, M.; Visser, F.; Bose, P.; Gallo, M.; Yong, V. W.
10.1101/2022.09.13.507846 — cancer biology — Posted on 2022-09-16
2179 The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division
Hurtig, F.; Burgers, T. C. Q.; Cezanne, A.; Jiang, X.; Mol, F. N.; Traparic, J.; Tarrason Risa, G.; Arashiro Pulschen, A.; Harker-Kirschneck, L.; Saric, A.; Vlijm, R.; Baum, B.
10.1101/2022.09.16.508273 — cell biology — Posted on 2022-09-16
2180 Transcription factor FOXM1 specifies the loading of chromatin DNA to extracellular vesicles
Zhang, Y.; Ding, N.; Li, Y.; Zhao, X.; Yang, S.; Fu, P.; Peng, Y.; Cheng, H.; Ouyang, M.; Wang, R.; Wang, Y.; Liu, H.; Chen, Y.; Huang, X.; Yu, L.; Tan, Y.
10.1101/2022.01.27.477315 — cell biology — Posted on 2022-09-16
2183 Dynamics of annatto pigment synthesis and accumulation revealed by integrated chemical, anatomical, and RNA-Seq analyses
Moreira, V. S.; de Souza, V. C.; Soares, V. L. F.; Sousa, A. O.; de Nascimento, K. T. d. S.; de Santana, M. R.; Reboucas, T. N. H.; Leitao, C. A. E.; Goliatt, P. V. Z. C.; Faria, D. V.; Otoni, W. C.; Costa, M. G. C.
10.1101/2022.09.14.507995 — plant biology — Posted on 2022-09-16
2184 Self-supervised deep learning for pan-cancer mutation prediction from histopathology
Saldanha, O. L.; Loeffler, C. M. L.; Niehues, J. M.; van Treeck, M.; Seraphin, T. P.; Hewitt, K. J.; Cifci, D.; Veldhuizen, G. P.; Ramesh, S.; Pearson, A. T.; Kather, J. N.
10.1101/2022.09.15.507455 — cancer biology — Posted on 2022-09-16
2186 Sister chromatid cohesion establishment during DNA replication termination
Cameron, G.; Gruszka, D.; Xie, S.; Nasmyth, K. A.; Srinivasan, M.; Yardimci, H.
10.1101/2022.09.15.508094 — biophysics — Posted on 2022-09-16
2189 Oct4 interacts with subnucleosomal particles generated by Brg1 at enhancers
Nocente, M. C.; Mesihovic, A.; Drouineau, E.; Albawardi, W.; Dulary, C.; Ribierre, F.; Picaud, H.; Alibert, O.; Aude, J.-C.; Gilbert, N.; Ochsenbein, F.; Chantalat, S.; Gerard, M.
10.1101/2022.09.15.507958 — genomics — Posted on 2022-09-16
2191 Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum
Sun, S. Y.; Zarko, L.-a. S.; Pintilie, G. D.; Kim, C. Y.; Staggers, S. R.; Schmid, M. F.; Egan, E. S.; Chiu, W.; Boothroyd, J. C.
10.1101/2022.09.14.508031 — cell biology — Posted on 2022-09-16
2192 MTCH2 is a mitochondrial outer membrane protein insertase
Guna, A.; Stevens, T. A.; Inglis, A. J.; Replogle, J. M.; Esantsi, T. K.; Muthukumar, G.; Shaffer, K. C. L.; Wang, M. L.; Pogson, A. N.; Jones, J. J.; Lomenick, B.; Chou, T.-F.; Weissman, J. S.; Voorhees, R. M.
10.1101/2022.09.15.508165 — cell biology — Posted on 2022-09-16
2195 The filipodia-like protrusions of adjacent somatic cells shape the developmental potential of mouse oocytes
Crozet, F.; Letort, G.; Da Silva, C.; Eichmuller, A.; Tortorelli, A. F.; Belle, M.; Dumont, J.; Piolot, T.; Dauphin, A.; Coulpier, F.; Chedotal, A.; Maitre, J.-L.; Verlhac, M.-H.; Clarke, H.; Terret, M.-E.
10.1101/2022.09.15.508092 — cell biology — Posted on 2022-09-16
2196 Cellular Heterogeneity of Pluripotent Stem Cell Derived Cardiomyocyte Grafts is Mechanistically Linked to Treatable Arrhythmias
Selvakumar, D.; Clayton, Z. E.; Prowse, A.; Dingwall, S.; George, J.; Shah, H.; Chen, S.; Hume, R. D.; Tjahjadi, L.; Igoor, S.; Skelton, R. J. P.; Hing, A.; Paterson, H.; Foster, S. L.; Pearson, L.; Wilkie, E.; Jeyaprakash, P.; Wu, Z.; McArthur, J. R.; Barry, T.; Lu, J.; Tran, V.; Bennett, R.; Kotake, Y.; Campbell, T.; Turnbull, S.; Nguyen, Q.; Ni, G.; Grieve, S. M.; Palpant, N. J.; Pathan, F.; Kizana, E.; Kumar, S.; Gray, P. P.; Chong, J. J. H.
10.1101/2022.09.15.500719 — cell biology — Posted on 2022-09-16
2197 Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions
Weng, A.; Rabin, E. E.; Flozak, A. S.; Aillon, R. P.; Chiarella, S. E.; Gottardi, C. J.
10.1101/2022.09.15.508190 — cell biology — Posted on 2022-09-16
2201 Inverse correlation between stress response and virulence factor expression in FASII antibiotic-adapted Staphylococcus aureus and consequences for infection
Wongdontree, P.; Millan-Oropeza, A.; Upfold, J.; Lavergne, J.-P.; Halpern, D.; Gloux, K.; Page, A.; Kenanian, G.; Grangeasse, C.; Henry, C.; Anba-Mondoloni, J.; Gruss, A.
10.1101/2022.09.09.506511 — microbiology — Posted on 2022-09-16
2208 A highly contiguous genome assembly of red perilla (Perilla frutescens) domesticated in Japan
Tamura, K.; Sakamoto, M.; Tanizawa, Y.; Mochizuki, T.; Matsushita, S.; Kato, Y.; Ishikawa, T.; Okuhara, K.; Nakamura, Y.; Bono, H.
10.1101/2022.09.16.508052 — plant biology — Posted on 2022-09-16
2212 Investigating manta ray collective movements via drone surveys
Perryman, R. J. Y.; Brown, C.; Pasian, N.; Ward, A. J. W.; Kent, M. I. A.
10.1101/2022.07.29.501955 — animal behavior and cognition — Posted on 2022-09-16
2217 Droplet microfluidics forward for tracing target cells at single-cell transcriptome resolution
Liu, Y.; Wang, S.; Lyu, M.; Xie, R.; Guo, W.; He, Y.; Shi, X.; Wang, Y.; Qi, J.; Zhu, Q.; Zhang, H.; Luo, T.; Chen, H.; Zhu, Y.; Dong, X.; Li, Z.; Gu, Y.; Mu, F.; Liu, L.; Xu, X.; Liu, Y.
10.1101/2022.09.13.507865 — cell biology — Posted on 2022-09-16
2218 Nuclear GAPDH in cortical microglia mediates stress-induced cognitive inflexibility
Ramos, A.; Ishizuka, K.; Namkung, H.; Hayes, L. N.; Saito, A.; Hayashida, A.; Srivastava, R.; Elkins, N.; Palen, T.; Carloni, E.; Tsujimura, T.; Calva, C.; Ikemoto, S.; Rais, R.; Slusher, B. S.; Niwa, M.; Saitoh, T.; Takimoto, E.; Sawa, A.
10.1101/2022.06.21.497065 — molecular biology — Posted on 2022-09-16
2219 SARS-CoV-2 infection of human neurons requires endosomal cell entry and can be blocked by inhibitors of host phosphoinositol-5 kinase
Kettunen, P. P.; Lesnikova, A.; Räsänen, N.; Ojha, R.; Palmunen, L.; Laakso, M.; Lehtonen, S.; Kuusisto, J.; Pietiläinen, O.; Vapalahti, O.; Koistinaho, J.; Rolova, T.; Balistreri, G.
10.1101/2022.09.14.508057 — neuroscience — Posted on 2022-09-16
2220 Systemic and intrinsic functions of ATRX in glial cell fate and CNS myelination
Rowland, M. E.; Jiang, Y.; Shafiq, S.; Ghahramani, A.; Pena-Ortiz, M. A.; Dumeaux, V.; Berube, N. G.
10.1101/2022.09.15.508143 — neuroscience — Posted on 2022-09-16
2222 Meteorin alleviates Paclitaxel-induced peripheral neuropathy in mice
Sankaranarayanan, I.; Tavares-Ferreira, D.; He, L.; Kume, M.; Mwirigi, J. M.; Madsen, T. M.; Petersen, K. A.; Munro, G.; Price, T. J.
10.1101/2022.09.13.507857 — neuroscience — Posted on 2022-09-16
2223 3D electron diffraction reveals the chiral nature of the malaria pigment crystal hemozoin
Klar, P. B.; Waterman, D.; Gruene, T.; Mullick, D.; Song, Y.; Gilchrist, J. B.; Wen, W.; Biran, I.; Houben, L.; Regev-Rudzki, N.; Dzikowski, R.; Palatinus, L.; Zhang, P.; Leiserowitz, L.; Elbaum, M.
10.1101/2022.09.15.507960 — microbiology — Posted on 2022-09-16
2224 BRAin-wide Neuron quantification Tool reveals strong sexual dimorphism in the evolution of fear memory
Franceschini, A.; Mazzamuto, G.; Checcucci, C.; Chicci, L.; Fanelli, D.; Pavone, F. S.; Silvestri, L.
10.1101/2022.09.12.507637 — neuroscience — Posted on 2022-09-16
2225 APP family member dimeric complexes are formed predominantly in synaptic compartments
Schilling, S.; August, A.; Meleux, M.; Conradt, C.; Tremmel, L.; Teigler, S.; Koo, E. H.; Kins, S.; Eggert, S.
10.1101/2022.09.13.507759 — neuroscience — Posted on 2022-09-16
2226 Involvement of an IgE/Mast cell/B cell amplification loop in abdominal aortic aneurysm progression
Loste, A.; Clement, M.; Delbosc, S.; Guedj, K.; Senemaud, J.; Gaston, A.-T.; Morvan, M.; Even, G.; Gautier, G.; Eggel, A.; Arock, M.; Procopio, E.; Deschildre, C.; Louedec, L.; Michel, J.-B.; Deschamps, L.; Castier, Y.; Coscas, R.; Alsac, J.-M.; Launay, P.; Caligiuri, G.; Nicoletti, A.; Le Borgne, M.
10.1101/2022.09.13.507783 — pathology — Posted on 2022-09-16
2227 A new technology for isolating organellar membranes provides fingerprints of lipid bilayer stress
Reinhard, J.; Starke, L.; Klose, C.; Haberkant, P.; Hammaren, H.; Stein, F.; Klein, O.; Berhorst, C.; Stumpf, H.; Saenz, J. P.; Hub, J.; Schuldiner, M.; Ernst, R.
10.1101/2022.09.15.508072 — cell biology — Posted on 2022-09-16
2228 A novel gyrovirus associated with a fatal respiratory disease in yellow-eyed penguin (Megadyptes antipodes) chicks
Wierenga, J. R.; Morgan, K. J.; Hunter, S.; Taylor, H. S.; Argilla, L. S.; Webster, T.; Dubrulle, J.; Jorge, F.; Bostina, M.; Burga, L.; Holmes, E. C.; McInnes, K.; Geoghegan, J. L.
10.1101/2022.09.15.508173 — microbiology — Posted on 2022-09-16
2229 In vivo chromatic and spatial tuning of foveolar retinal ganglion cells in Macaca fascicularis
Godat, T.; Cottaris, N. P.; Patterson, S.; Kohout, K.; Parkins, K.; Yang, Q.; Strazzeri, J. M.; McGregor, J. E.; Brainard, D. H.; Merigan, W. H.; Williams, D. R.
10.1101/2022.02.28.482294 — neuroscience — Posted on 2022-09-16
2234 Association of Whole-Person Eigen-Polygenic Risk Scores with Alzheimer's Disease
Kharaghani, A.; Tio, E.; Milic, M.; Bennett, D. A.; De Jager, P. L.; Schneider, J. A.; Sun, L.; Felsky, D.
10.1101/2022.09.13.507735 — genetics — Posted on 2022-09-16
2235 European scenarios for future biological invasions
Perez-Granados, C.; Lenzner, B.; Golivets, M.; Saul, W.-C.; Jeschke, J. M.; Essl, F.; Peterson, G. D.; Rutting, L.; Latombe, G.; Adriaens, T.; Aldridge, D. C.; Bacher, S.; Bernardo-Madrid, R.; Brotons, L.; Diaz, F.; Gallardo, B.; Genovesi, P.; Gonzalez-Moreno, P.; Kuhn, I.; Kutlesa, P.; Leung, B.; Liu, C.; Pagitz, K.; Pastor, T.; Pauchard, A.; Rabitsch, W.; Roy, H. E.; Robertson, P.; Seebens, H.; Solarz, W.; Starfinger, U.; Tanner, R.; Vila, M.; Roura-Pascual, N.
10.1101/2022.09.13.507777 — ecology — Posted on 2022-09-16
2237 Biphasic release propensity of mucin granules is supervised by TSPAN8
Wojnacki, J.; Lujan, A.; Foresti, O.; Aranda, C.; Bigliani, G.; Pena Rodriguez, M.; Brouwers, N.; Malhotra, V.
10.1101/2022.09.14.507971 — cell biology — Posted on 2022-09-16
2240 Feature-space selection with banded ridge regression
Dupre la Tour, T.; Eickenberg, M.; Nunez-Elizalde, A. O.; Gallant, J. L.
10.1101/2022.05.05.490831 — neuroscience — Posted on 2022-09-16
2241 Intrinsically disordered proteins SAID1/2 condensate on SERRATE/ARS2 for dual inhibition of miRNA biogenesis in Arabidopsis
Shang, B.; Wang, L.; Yan, X.; Li, Y.; Li, C.; Wu, C.; Wang, T.; Guo, X.; Choi, S.; Zhang, T.; Wang, Z.; Tong, C.-Y.; Oh, T.; Zhang, X.; Wang, Z.; Peng, X.; Zhang, X.
10.1101/2022.09.13.507836 — plant biology — Posted on 2022-09-16
2242 Three-dimensional motions of GroEL during substrate protein recognition
Stapleton, K.; Mizobata, T.; Miyazaki, N.; Takatsuji, T.; Kato, T.; Iwasaki, K.; Standley, D. M.; Kawamura, T.; Nakane, T.; Takagi, J.; Mizohata, E.
10.1101/2022.09.15.508192 — biophysics — Posted on 2022-09-16
2244 Single-cell brain organoid screening identifies developmental defects in autism
Li, C.; Fleck, J. S.; Martins-Costa, C.; Burkard, T. R.; Stuempflen, M.; Vertesy, A.; Peer, A. M.; Esk, C.; Elling, U.; Kasprian, G.; Corsini, N. S.; Treutlein, B.; Knoblich, J. A.
10.1101/2022.09.15.508118 — developmental biology — Posted on 2022-09-15
2247 A toxin-antitoxin system ensures plasmid stability in Coxiella burnetii
Wachter, S.; Cockrell, D. C.; Miller, H. E.; Virtaneva, K.; Kanakabandik, K.; Darwitz, B.; Heinzen, R. A.; Beare, P. A.
10.1101/2022.09.15.508156 — microbiology — Posted on 2022-09-15
2248 Genomic variation during culture-adaptation of genetically complex Plasmodium falciparum clinical isolates
Claessens, A.; Stewart, L. B.; Drury, E.; Ahouidi, A. D.; Amambua-Ngwa, A.; Diakite, M.; Kwiatkowski, D. P.; Awandare, G. A.; Conway, D. J.
10.1101/2022.09.14.507918 — microbiology — Posted on 2022-09-15
2249 Mevalonate metabolites contribute to granulocyte chemotaxis and mortality in murine endotoxemia
Hussain, J.; Ousley, C. G.; Krauklis, S. A.; Dray, E. L.; Drnevich, J.; Justyna, K.; Distefano, M. D.; McKim, D. B.
10.1101/2022.09.13.507840 — immunology — Posted on 2022-09-15
2250 Structural basis for breadth development in a HIV-1 neutralizing antibody
Henderson, R.; Zhou, Y.; Stalls, V.; Wiehe, K.; Saunders, K. O.; Wagh, K.; Anasti, K.; Barr, M.; Parks, R.; Alam, S. M.; Korber, B.; Haynes, B. F.; Bartesaghi, A.; Acharya, P.
10.1101/2022.09.14.507935 — immunology — Posted on 2022-09-15
2252 Microglial colonisation of the developing brain is facilitated by clonal expansion of highly proliferative progenitors and follows an allometric scaling
Barry-Carroll, L.; Greulich, P.; Marshall, A. R.; Riecken, K.; Fehse, B.; Askew, K. E.; Li, K.; Garaschuk, O.; Menassa, D. A.; Gomez-Nicola, D.
10.1101/2022.09.15.507569 — neuroscience — Posted on 2022-09-15
2253 Single cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation.
Nishimura, K.; Yang, S.; Lee, K.; Asgrimsdottir, E. S.; Nikouei, K.; Paslawski, W.; Gnodde, S.; Lyu, G.; Hu, L.; Salto, C.; Svenningsson, P.; Hjerling-Leffler, J.; Linnarsson, S.; Arenas, E.
10.1101/2022.09.15.507987 — neuroscience — Posted on 2022-09-15
2255 Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment
Li, N.; Zhu, Q.; Tian, Y.; Ahn, K. J.; Wang, X.; Cramer, Z.; Folkert, I. W.; Yu, P.; Jou, J.; Adams-Tzivelekidis, S.; Sehgal, P.; Mahmoud, N. N.; Aarons, C. B.; Roses, R. E.; Thomas-Tikhonenko, A.; Furth, E. E.; Stanger, B. Z.; Rustgi, A. K.; Haldar, M.; Katona, B. W.; Tan, K.; Lengner, C. J.
10.1101/2022.09.13.506996 — cancer biology — Posted on 2022-09-15
2256 Oct4 interacts with subnucleosomal particles generated by Brg1 at enhancers
Gerard, M.; Nocente, M. C.; Mesihovic, A.; Drouineau, E.; Picaud, H.; Aude, J.-C.; Ochsenbein, F.; Albawardi, W.; Gilbert, N.; Dulary, C.; Ribierre, F.; Alibert, O.; Chantalat, S.
10.1101/2022.09.15.507958 — genomics — Posted on 2022-09-15
2257 Survey of activation-induced genome architecture reveals a novel enhancer of Myc
Chan, W. F.; Coughlan, H. D.; Ruhle, M.; Iannarella, N.; Alvarado, C.; Groom, J. R.; Keenan, C. R.; Kueh, A. J.; Wheatley, A. K.; Smyth, G.; Allan, R. S.; Johanson, T. M.
10.1101/2022.09.14.508046 — genetics — Posted on 2022-09-15
2261 Heat induces multi-omic and phenotypic stress propagation in zebrafish embryos
Feugere, L.; Bates, A.; Emagbetere, T.; Chapman, E.; Malcolm, L.; Bulmer, K.; Hardege, J.; Beltran-Alvarez, P.; Valero, K. C. W.
10.1101/2022.09.15.508176 — molecular biology — Posted on 2022-09-15
2264 Emergence of plasmid-mediated RND-type efflux pump gene cluster tmexCD-toprJ in Shewanella xiamenensis in a water environment
Dao, T. D.; Takemura, T.; Kasuga, I.; Hirabayashi, A.; Nga, N. T.; Anh, P. H. Q.; Tu, N. D.; Trang, L. T.; Tran, H. H.; Shibayama, K.; Hasebe, F.; Suzuki, M.
10.1101/2022.09.15.508154 — microbiology — Posted on 2022-09-15
2266 Infant antibody repertoires during the first two years of influenza vaccination
Kuraoka, M.; Curtis, N. C.; Watanabe, A.; Tanno, H.; Shin, S.; Ye, K.; Macdonald, E.; Lavidor, O.; Kong, S.; Von Holle, T.; Windsor, I. W.; Ippolito, G. C.; Georgiou, G.; Walter, E. B.; Kelsoe, G. H.; Harrison, S. C.; Moody, M. A.; Bajic, G.; Lee, J.
10.1101/2022.09.13.507806 — immunology — Posted on 2022-09-15
2267 Single-nuclei transcriptomics of mammalian prion diseases identifies dynamic gene signatures shared between species
Dimitriadis, A.; Zhang, F.; Murphy, T.; Trainer, T.; Jaunmuktane, Z.; Schmidt, C.; Nazari, T.; Linehan, J.; Brandner, S.; Collinge, J.; Mead, S.; Vire, E.
10.1101/2022.09.13.507650 — neuroscience — Posted on 2022-09-15
2268 The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7
Wang, K.; Lee, C.-W.; Sui, X.; Kim, S.; Wang, S.; Higgs, A. B.; Baublis, A. J.; Voth, G. A.; Liao, M.; Walther, T. C.; Farese, R. V.
10.1101/2022.09.15.508141 — biochemistry — Posted on 2022-09-15
2269 Widely Distributed Biosynthetic Cassette Is Responsible for Diverse Plant Side-Chain-Cross-Linked Cyclopeptides
Lima, S. T.; Ampolini, B. G.; Underwood, E. B.; Graf, T. N.; Earp, C. E.; Khedi, I. C.; Chekan, J. R.
10.1101/2022.09.15.507631 — biochemistry — Posted on 2022-09-15
2273 Colistin resistance mutations in phoQ sensitize Klebsiella pneumoniae to IgM-mediated complement killing
van der Lans, S. P. A.; Janet-Maitre, M.; Masson, F. M.; Walker, K. A.; Doorduijn, D. J.; Janssen, A. B.; van Schaik, W.; Attree, I.; Rooijakkers, S. H. M.; Bardoel, B. W.
10.1101/2022.09.15.508115 — microbiology — Posted on 2022-09-15
2275 SynBOLD-DisCo: Synthetic BOLD images for distortion correction of fMRI without additional calibration scans
Yu, T.; Cai, L. Y.; Morgan, V. L.; Goodale, S. E.; Englot, D. J.; Chang, C. E.; Landman, B. A.; Schilling, K. G.
10.1101/2022.09.13.507794 — bioengineering — Posted on 2022-09-15
2276 Allelic and Gene Dosage Effects Involving Uromodulin Aggregates Drive Autosomal Dominant Tubulointerstitial Kidney Disease
Schiano, G.; Lake, J.; Mariniello, M.; Schaeffer, C.; Harvent, M.; Rampoldi, L.; Olinger, E. G.; Devuyst, O.
10.1101/2022.09.13.507770 — genetics — Posted on 2022-09-15
2280 Major Histocompatibility Complex class I heavy chains localize in both cytoplasmic and nuclear compartment
Gomez-Herranz, M.; Dziadosz, A.; Mikac, S.; Rychlowski, M.; Fahraeus, R.; Marek-Trzonkowska, N.; Chrusciel, E.; Urban-Wojciuk, Z.; Papak, I.; Arcimowicz, L.; Marjanski, T.; Rzyman, W.; Sznarkowska, A.
10.1101/2022.09.13.507738 — immunology — Posted on 2022-09-15
2283 Viridiplantae-specific GLXI and GLXII isoforms co-evolved and detoxify glucosone in planta
Balparda, M.; Schmitz, J.; Duemmel, M.; Wuthenow, I. C.; Schmidt, M.; Alseekh, S.; Fernie, A. R.; Lercher, M. J.; Maurino, V. G.
10.1101/2022.09.13.507747 — plant biology — Posted on 2022-09-15
2284 Molecular landscape and functional characterization of centrosome amplification in ovarian cancer
Sauer, C. M.; Hall, J. A.; Couturier, D.-L.; Bradley, T.; Piskorz, A. M.; Griffiths, J.; Sawle, A.; Eldridge, M. D.; Smith, P.; Hosking, K.; Reinius, M. A.; Morrill Gavarro, L.; Mes-Masson, A.-M.; Ennis, D.; Millan, D.; Hoyle, A.; McNeish, I. A.; Jimenez-Linan, M.; Correia Martins, F.; Tischer, J.; Vias, M.; Brenton, J. D.
10.1101/2022.09.13.507750 — cancer biology — Posted on 2022-09-15
2286 The Aphelenchoides genomes reveal major events of horizontal gene transfers in clade IV nematodes
Lai, C.-K.; Lee, Y.; Ke, H.-M.; Lu, M. R.; Liu, W.-A.; Lee, H.-H.; Liu, Y.-C.; Yoshiga, T.; Kikuchi, T.; Chen, P. J.; Tsai, I. J.
10.1101/2022.09.13.507733 — genomics — Posted on 2022-09-15
2287 Genomic erosion in the assessment of species extinction risk and recovery potential
van Oosterhout, C. v.; Speak, S. A.; Birley, T.; Bortoluzzi, C.; Percival-Alwyn, L.; Urban, L. H.; Groombridge, J. J.; Segelbacher, G.; Morales, H. E.
10.1101/2022.09.13.507768 — genomics — Posted on 2022-09-15
2288 Loss of H3.1K27me1 in Arabidopsis confers resistance to Geminivirus by sequestering DNA repair proteins onto rDNA and defense-related genes
Wang, Z.; Gonzalez, C. M. C.; Zhao, C.; Tong, C.-Y.; Li, C.; Liu, Z.; Xie, K.; Zhu, J.; Wu, Z.; Peng, X.; Jacob, Y.; Michaels, S. D.; Jacobsen, S. E.; Zhang, X.
10.1101/2022.09.13.507805 — genetics — Posted on 2022-09-15
2290 Chilean bee diversity: Contrasting patterns of species and phylogenetic turnover along a large-scale ecological gradient
Marshall, L.; Ascher, J. S.; Villagra, C.; Beaugendre, A.; Herrera, V.; Henriquez-Piskulich, P.; Vera, A.; Vereecken, N. J.
10.1101/2022.09.13.506767 — ecology — Posted on 2022-09-15
2293 Multiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health
Daly, J. L.; Danson, C. M.; Lewis, P. A.; Riccardo, S.; Di Filippo, L.; Cacchiarelli, D.; Cross, S. J.; Heesom, K. J.; Ballabio, A.; Edgar, J. R.; Cullen, P. J.
10.1101/2022.09.13.507260 — neuroscience — Posted on 2022-09-15
2295 Suggesting disease associations for overlooked metabolites using literature from metabolic neighbours
Delmas, M.; Filangi, O.; Duperier, C.; Paulhe, N.; Vinson, F.; Rodriguez-Mier, P.; Giacomoni, F.; Jourdan, F.; Frainay, C.
10.1101/2022.09.13.507596 — bioinformatics — Posted on 2022-09-15
2298 Association of Whole-Person Eigen-Polygenic Risk Scores with Alzheimer's Disease
Kharaghani, A.; Tio, E.; Milic, M.; Bennett, D. A.; De Jager, P. L.; Schneider, J. A.; Sun, L.; Felsky, D.
10.1101/2022.09.13.507735 — genetics — Posted on 2022-09-15
2300 Convergent community assembly among globally separated acidic cave biofilms
Jones, D. S.; Schaperdoth, I.; Northup, D. E.; Gomez-Cruz, R.; Macalady, J. L.
10.1101/2022.09.13.507874 — microbiology — Posted on 2022-09-15
2301 Preparatory neural activity differs between Selective Attention and Perceptual Expectations
G. Penalver, J. M.; Lopez-Garcia, D.; Gonzalez-Garcia, C.; Aguado-Lopez, B.; Gorriz, J. M.; Ruz, M.
10.1101/2022.09.13.507583 — neuroscience — Posted on 2022-09-15
2304 Reduced coenzyme Q synthesis confers non-target site resistance to the herbicide thaxtomin A
Casey, C.; Köcher, T.; Champion, C.; Jandrasits, K.; Mosiolek, M.; Bonnot, C.; Dolan, L.
10.1101/2022.09.13.507736 — plant biology — Posted on 2022-09-15
2305 Phenotypic profiling of macrocyclic lactones on parasitic Schistosoma flatworms
Ryan, K. T.; Wheeler, N. J.; Kamara, I. K.; Johnson, H.; Humphries, J. E.; Zamanian, M.; Chan, J. D.
10.1101/2022.09.12.507717 — pharmacology and toxicology — Posted on 2022-09-15
2306 Crowding induced morphological changes in synthetic lipid vesicles determined using smFRET
Quinn, S. D.; Dresser, L.; Graham, S.; Conteduca, D.; Shepherd, J.; Leake, M. C.
10.1101/2022.05.31.494132 — biophysics — Posted on 2022-09-15
2308 Spatially resolved transcriptomic profiling of degraded and challenging fresh frozen samples
Mirzazadeh, R.; Andrusivova, Z.; Larsson, L.; Newton, P.; Alonso Galicia, L.; Abalo, X. M.; Avijgan, M.; Kvastad, L.; Denadai-Souza, A.; Stakenborg, N.; Firsova, A. B.; Shamikh, A.; Jurek, A.; Schultz, N.; Nister, M.; Samakovlis, C.; Boeckxstaens, G.; Lundeberg, J.
10.1101/2022.09.13.507728 — genomics — Posted on 2022-09-15
2309 Immune Isoform Atlas: Landscape of alternative splicing in human immune cells
Inamo, J.; Suzuki, A.; Ueda, M.; Yamaguchi, K.; Nishida, H.; Suzuki, K.; Kaneko, Y.; Takeuchi, T.; Ishihama, Y.; Yamamoto, K.; Kochi, Y.
10.1101/2022.09.13.507708 — genetics — Posted on 2022-09-15
2310 O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Contribute to the Mutational Trajectory in Variants of Concern
Gonzalez-Rodriguez, E.; Zol-Hanlon, M.; Bineva-Todd, G.; Marchesi, A.; Skehel, M.; Mahoney, K.; Roustan, C.; Borg, A.; Di Vagno, L.; Kjaer, S.; Wrobel, A. G.; Benton, D. J.; Nawrath, P.; Flitsch, S. L.; Joshi, D.; Gonzalez-Ramirez, A. M.; Wilkinson, K. A.; Wilkinson, R. J.; Hurtado-Guerrero, R.; Malaker, S. A.; Schumann, B.
10.1101/2022.09.15.508093 — cell biology — Posted on 2022-09-15
2311 Global characterization of gene expression in the brain of starved immature R. prolixus
Nevoa, J. C.; Estivalis, J. M. L.; Pais, F. S.-M.; Pinto Marliere, N.; Fernandes, G. R.; Lorenzo, M. G.; Guarneri, A. A.
10.1101/2022.09.01.506236 — molecular biology — Posted on 2022-09-15
2312 Bacterial Microbiome of Foreskin Tissue: Impact of Short-course PrEP and Host Inflammation
Maust, B. S.; Petkov, S.; Herrera, C.; Feng, C.; Brown, B. P.; Lebina, L.; Opoka, D.; Ssemata, A.; Pillay, N.; Serwanga, J.; Seatlholo, P.; Namubiru, P.; Odoch, G.; Mugaba, S.; Seiphetlo, T.; Gray, C. M.; Kaleebu, P.; Webb, E. L.; Martinson, N.; Chiodi, F.; Fox, J.; Jaspan, H. B.; the CHAPS team,
10.1101/2022.08.29.505718 — microbiology — Posted on 2022-09-15
2314 Dormancy of disseminated prostate cancer cells in the bone cortex is induced by osteoblasts
Liu, R.; Su, S.; Liu, K.; Xing, J.; Stangis, M.; Jacho, D. P.; Yildirim-Ayan, E. D.; Yu, H.; Chen, B.; Li, X.
10.1101/2022.09.02.506436 — cancer biology — Posted on 2022-09-15
2315 A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2
Padroni, G.; Bikaki, M.; Novakovic, M.; Wolter, A. C.; Ruedisser, S. H.; Gossert, A. D.; Leitner, A.; Allain, F. H.- T.
10.1101/2022.09.15.507991 — biophysics — Posted on 2022-09-15
2316 Fast bioluminescent nucleic acid detection using one-pot isothermal amplification and dCas9-based split luciferase complementation
van der Veer, H. J.; van Aalen, E. A.; Michielsen, C. M. S.; Hanckmann, E. T. L.; Deckers, J.; van Borren, M. M. G. J.; Flipse, J.; Loonen, A. J. M.; Schoeber, J. P. H.; Merkx, M.
10.1101/2022.09.12.507659 — bioengineering — Posted on 2022-09-15
2317 MicroFPGA: an affordable FPGA platform for microscope control
Deschamps, J.; Kieser, C.; Hoess, P.; Deguchi, T.; Ries, J.
10.1101/2022.06.07.495178 — biophysics — Posted on 2022-09-15
2319 Metabolic Signatures of Performance in Elite World Tour Professional Cyclists
Nemkov, T.; Cendali, F.; Stefanoni, D.; Martinez, J.; Hansen, K. C.; San-Millan, I.; D'Alessandro, A.
10.1101/2022.09.13.507793 — biochemistry — Posted on 2022-09-15
2321 4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis
Levy, T.; Voeltzke, K.; Hauffe, L.; Alasad, K.; Snaebjornsson, M.; Marciano, R.; Scharov, K.; Planque, M.; Vriens, K.; Christen, S.; Funk, C. M.; Hassiepen, C.; Kahler, A.; Heider, B.; Picard, D.; Lim, J. K.; Bas, Z.; Bendrin, K.; Vargas-Toscano, A.; Kahlert, U.; Remke, M.; Elkabets, M.; Grunewald, T. G.; Reichert, A. S.; Fendt, S.-M.; Schulze, A.; Reifenberger, G.; Rotblat, B.; Leprivier, G.
10.1101/2022.09.09.507243 — cell biology — Posted on 2022-09-15
2324 Protein arginine phosphorylation and de-phosphorylation facilitate protein homeostasis by an AAA+ chaperone protease system
Alver, R.; Hantke, I.; Cornejo, F. A.; Gunka, K.; Rämisch, S.; Moliere, N.; Charpentier, E.; Turgay, K.
10.1101/2022.09.15.508104 — microbiology — Posted on 2022-09-15
2325 Drug resistance-associated mutations in Plasmodium UBP-1 disrupt ubiquitin hydrolysis
Smith, C.; Henrici, R.; Karpiyevich, M.; Ansbro, M. R.; Hoshizaki, J.; van der Heden van Noort, G. J.; Ascher, D. B.; Sutherland, C. J.; Lee, M. C. S.; Artavanis-Tsakonas, K.
10.1101/2022.09.15.508122 — microbiology — Posted on 2022-09-15
2326 IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques
Nelson, C. E.; Foreman, T. W.; Kauffman, K. D.; Sakai, S.; Gould, S. T.; Fleegle, J. D.; Gomez, F.; NIAID/DIR Tuberculosis Imaging Program, ; Le Nouen, C.; Liu, X.; Burdette, T. L.; Garza, N. L.; Lafont, B. A. P.; Brooks, K.; Arlehamn, C. S. L.; Weiskopf, D.; Sette, A.; Hickman, H. D.; Buchholz, U. J.; Johnson, R. F.; Brenchley, J. M.; Via, L. E.; Barber, D. L.
10.1101/2022.09.13.507852 — immunology — Posted on 2022-09-15
2327 Style Transfer Generative Adversarial Networks to Harmonize Multi-Site MRI to a Single Reference Image to Avoid Over-Correction
Liu, M.; Zhu, A.; Maiti, P.; Thomopoulos, S. I.; Gadewar, S.; Chai, Y.; Kim, H.; Jahanshad, N.; Alzheimer's Disease Neuroimaging Initiative,
10.1101/2022.09.12.506445 — neuroscience — Posted on 2022-09-15
2329 PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell
Bergman, D. R.; Marazzi, L.; Chowkwale, M.; Maheshvare M, D.; Bidanta, S.; Mapder, T.; Li, J.
10.1101/2022.09.12.507681 — systems biology — Posted on 2022-09-15
2330 OPA1 Downregulation in Skeletal Muscle Induces MERC formation in an ATF4-Dependent Manner
Hinton, A.; Katti, P.; Mungai, M.; Hall, D.; Koval, O.; Shao, J.; Vue, Z.; Christensen, T. A.; Lopez, E. G.; Rostami, R.; Neikirk, K.; Lam, J.; Alghanem, A.; Ponce, J.; Hicsasmaz, I.; Streeter, J.; Schickling, B.; Bacevac, S.; Grueter, C.; Marshall, A.; Beasley, H. K.; DoKoo, Y.; Bodine, S.; Nava, N. G. R.; Quintana, A.; Trushina, E.; Weatherford, E.; Murray, S. A.; Salisbury, J.; Song, L.-S.; Grumbach, I.; Exil, V.; Pereira, R. O.; Glancy, B.; Abel, E. D.
10.1101/2022.09.12.507669 — biophysics — Posted on 2022-09-15
2332 Benchmarking thiolate driven photoswitching of cyanine dyes
Herdly, L.; Tinning, P. W.; Geiser, A.; Taylor, H.; Gould, G. W.; van de Linde, S.
10.1101/2022.09.15.507984 — biophysics — Posted on 2022-09-15
2333 Probing mechanical interaction of immune receptors and cytoskeleton by membrane nanotube extraction
Manca, F.; Eich, G.; N'Dao, O.; Normand, L.; Sengupta, K.; Limozin, L.; Puech, P.-H.
10.1101/2022.09.15.508080 — biophysics — Posted on 2022-09-15
2334 Submicron-sized in-situ osmotic pressure sensors for in-vitro applications in biology
Zhang, W.; Bertinetti, L.; Yavuzsoy, E. C.; Gao, C.; Schneck, E.; Fratzl, P.
10.1101/2022.09.13.507780 — biophysics — Posted on 2022-09-15
2335 Effect of Methamphetamine on Ultraweak Photon Emission and Level of Reactive Oxygen Species in Male Rat Brain
Lotfealian, A.; Esmaeilpour, T.; Anvari, M.; Namavar, M.; Karbalaei, N.; Shahedi, A.; Bokkon, I.; Zadeh-Haghigh, H.; Simon, C.; Salari, V.; Oblak, D.
10.1101/2022.09.14.508017 — biophysics — Posted on 2022-09-15
2337 Sorting of droplets at kHz rates using absorbance activated acoustic sorting
Richter, E. S.; Link, A.; McGrath, J. S.; Sparrow, R. W.; Gantz, M.; Medcalf, E. J.; Hollfelder, F.; Franke, T.
10.1101/2022.09.13.507732 — biophysics — Posted on 2022-09-15
2339 Direct digital sensing of protein biomarkers in solution
Krainer, G.; Saar, K. L.; Arter, W. E.; Welsh, T. J.; Czekalska, M. A.; Jacquat, R. P. B.; Peter, Q.; Traberg-Christensen, W.; Pujari, A.; Jayaram, A. K.; Challa, P.; Taylor, C. G.; van der Linden, L.-M.; Franzmann, T.; Owens, R. M.; Alberti, S.; Klenerman, D.; Knowles, T. P. J.
10.1101/2020.05.24.113498 — biophysics — Posted on 2022-09-15
2345 Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor
Morse, J. S.; Sheng, Y. J.; Hampton, J. T.; Sylvain, L. D.; Das, S.; Alugubelli, Y. R.; Chen, P.-H. C.; Yang, K. S.; Xu, S.; Fierke, C. A.; Liu, W. R.
10.1101/2022.09.14.508049 — biochemistry — Posted on 2022-09-15
2350 Environment-wide and epigenome-wide association study of adiposity in "Children of 1997" birth cohort
Zhao, J.; Fan, B.; Huang, J.; Cowling, B. J.; Au Yeung, S. L. R.; Baccarelli, A.; M. Leung, G.; Schooling, C. M.
10.1101/2022.09.12.507623 — genetics — Posted on 2022-09-15
2351 Cysteine post-translational modifications regulate protein interactions of caveolin-3
Ashford, F.; Brown, E.; Calaghan, S.; Jayasinghe, I.; Henderson, C.; Fuller, W.; Wypijewski, K.
10.1101/2022.09.15.508083 — cell biology — Posted on 2022-09-15
2352 COP I and II dependent trafficking controls ER-associated degradation in mammalian cells
Ogen-Shtern, N.; Chang, C.; Saad, H.; Mazkereth, N.; Patel, C.; Shenkman, M.; Lederkremer, G. Z.
10.1101/2022.04.07.487480 — cell biology — Posted on 2022-09-15
2353 Gene amplifications cause high-level resistance against albicidin in Gram-negative bacteria
Saathoff, M.; Kosol, S.; Semmler, T.; Wolf, S. A.; Dimos, N.; Kupke, J.; Seidel, M.; Ghaziasaeedi, F.; Tedin, K.; Kuropka, B.; Czyszczon, W.; Ghilarov, D.; Graetz, S.; Heddle, J. G.; Loll, B.; Suessmuth, R. D.; Fulde, M.
10.1101/2022.09.15.507240 — microbiology — Posted on 2022-09-15
2354 Interdigitated immunoglobulin arrays form the hyperstable surface layer of the extremophilic bacterium Deinococcus radiodurans
von Kuegelgen, A.; van Dorst, S.; Yamashita, K.; Sexton, D. L.; Tocheva, E. I.; Murshudov, G. N.; Alva, V.; Bharat, T.
10.1101/2022.09.15.508085 — microbiology — Posted on 2022-09-15
2355 Recent O-antigen diversification masks highly pathogenic STEC O104:H4
Lang, C.; Fruth, A.; Campell, I. W.; Jenkins, C.; Smith, P.; Strockbine, N.; Weill, F.-X.; Nübel, U.; Grad, Y. H.; Waldor, M. K.; Flieger, A.
10.1101/2022.09.15.508078 — microbiology — Posted on 2022-09-15
2356 B/T cell crosstalk and aberrant inflammatory IgG exacerbate autoimmune intestinal inflammation
Gadjalova, I.; Heinze, J. M.; Goess, M. C.; Hofmann, J.; Albers, J. J.; Spallek, R.; Blissenbach, B.; Buck, A.; Weber, M.-C.; Scherer, E.; Kampick, M.; Oellinger, R.; Krut, O.; Rad, R.; Steiger, K.; Winter, C.; Janssen, K.-P.; Neumann, P.-A.; Geha, R. S.; Ruland, J.; Keppler, S. J.
10.1101/2022.09.12.507066 — immunology — Posted on 2022-09-15
2358 Anchors for Time, Distance, and Magnitude in Virtual Movements
Gladhill, K. A.; Robinson, E. M.; Stanfield-Wiswell, C.; Bader, F.; Wiener, M.
10.1101/2022.09.12.507649 — neuroscience — Posted on 2022-09-15
2359 Altered plasma membrane abundance of the sulfatide-binding protein NF155 links glycosphingolipid imbalances to demyelination
McKie, S. J.; Nicholson, A. S.; Smith, E.; Fawke, S.; Caroe, E.; Williamson, J. C.; Butt, B. G.; Kolarov, D.; Peterka, O.; Holcapek, M.; Lehner, P. J.; Graham, S. C.; Deane, J. E.
10.1101/2022.09.15.508082 — neuroscience — Posted on 2022-09-15
2362 Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks
Mohan, H.; An, X.; Xu, X. H.; Kondo, H.; Zhao, S.; Matho, K. S.; Musall, S.; Mitra, P. P.; Huang, Z. J.
10.1101/2021.12.30.474537 — neuroscience — Posted on 2022-09-15
2363 TACI: an ImageJ plugin for 3D calcium imaging analysis
Omelchenko, A. A.; Bai, H.; Hussain, S.; Tyrrell, J. J.; Ni, L.
10.1101/2021.09.28.462182 — neuroscience — Posted on 2022-09-15
2365 Novel Small Molecular Compound AE-848 Showed Potent Inhibitory Activity Against Human Hepatoblastoma Cells
Wang, J.; Zhou, Q.; Sun, L.; Xu, Y.; Jiang, Y.; Liu, X.; Li, S.; Li, H.; Zheng, C.; Jie, G.
10.1101/2022.09.12.507704 — cancer biology — Posted on 2022-09-15
2367 Mathematical reconstruction of the metabolic network in an in-vitro multiple myeloma model.
Vera-Siguenza, E.; Escribano-Gonzalez, C.; Serrano-Gonzalo, I.; Eskla, K.-L.; Spill, F.; Tennant, D. A.
10.1101/2022.09.12.507672 — bioengineering — Posted on 2022-09-15
2368 Targeting caveolae to pump bispecific antibody to TGF-β into diseased lungs enables ultra-low dose therapeutic efficacy
Kadam, A. H.; Kandasamy, K.; Buss, T.; Cederstrom, B.; Yang, C.; Narayanapillai, S.; Rodriguez, J.; Levin, M. D.; Koziol, J.; Olenyuk, B.; Borok, Z.; Chrastina, A.; Schnitzer, J. E.
10.1101/2022.09.12.507679 — bioengineering — Posted on 2022-09-15
2369 Dispensing with unnecessary assumptions in population genetics analysis
Labayle, O.; Tetley-Campbell, K. J.; van der Laan, M. J.; Ponting, C. P.; Beentjes, S. V.; Khamseh, A.
10.1101/2022.09.12.507656 — genetics — Posted on 2022-09-15
2374 A critical period for neurogenesis loss and cognitive decline in patients with mesial temporal lobe epilepsy patients
Ammothumkandy, A.; Corona, L.; Ravina, K.; Wolseley, V.; Jimenez, N.; Armacost, M.; D'Orazio, L. M.; Nelson, J.; Zuverza-Chavarria, V.; McCleary, C.; Nune, G.; Kalayjian, L.; Lee, D.; Lee, B.; Heck, C.; Chow, R. H.; Russin, J. J.; Liu, C. Y.; Smith, J. A.; Bonaguidi, M. A.
10.1101/2022.09.12.507339 — neuroscience — Posted on 2022-09-15
2375 The coarse mental map of the breast is anchored on the nipple
Long, K.; Fitzgerald, E.; Berger-Wolf, E.; Fawaz, A.; Greenspon, C.; Lindau, S.; Bensmaia, S. J.
10.1101/2022.09.14.507974 — neuroscience — Posted on 2022-09-15
2376 Haplotype resolved DNA methylome of African cassava genome
Zhong, Z.; Feng, S.; Mansfeld, B. N.; Ke, Y.; Qi, W.; Lim, Y.-W.; Gruissem, W.; Bart, R. S.; Jacobsen, S. E.
10.1101/2022.09.12.507674 — plant biology — Posted on 2022-09-15
2382 Brain Structure and Episodic Learning Rate in Cognitively Healthy Ageing
Frank, D.; Garo-Pascual, M.; Reyes Velasquez, P. A.; Frades, B.; Peled, N.; Zhang, L.; Strange, B.
10.1101/2022.05.03.490431 — neuroscience — Posted on 2022-09-15
2384 Single-cell characterisation of the hematopoietic bone marrow interactome in health and disease
Ennis, S.; Conforte, A.; O'Reilly, E.; Cichocka, T.; Pal Dhami, S.; Nicholson, P.; Krebs, P.; O Broin, P.; Szegezdi, E.
10.1101/2022.05.13.491790 — cancer biology — Posted on 2022-09-15
2385 An Inhibitory Function of TRPA1 Channels in TGF-β1-driven Fibroblast to Myofibroblast Differentiation
Geiger, F.; Zeitlmayr, S.; Staab-Weijnitz, C. A.; Rajan, S.; Breit, A.; Gudermann, T.; Dietrich, A.
10.1101/2022.04.12.488008 — cell biology — Posted on 2022-09-15
2391 Study on the interactions between cisplatin and cadherin
Wang, X.; Sun, J.; Shao, K.-; Zhi, H.; Lin, Y.; Fu, Y.; Liu, Z.
10.1101/2022.09.11.507507 — biochemistry — Posted on 2022-09-15
2393 Using eDNA metabarcoding to establish targets for freshwater fish composition following river restoration
Ito, G.; Yamauchi, H.; Shigeyoshi, M.; Ashino, K.; Yonashiro, C.; Asami, M.; Goto, Y.; Duda, J. J.; Yamanaka, H.
10.1101/2022.05.26.493668 — ecology — Posted on 2022-09-15
2394 Experimental and theoretical aspects of Golden Gate Assembly assays
Strzelecki, P.; Shpiruk, A.; Hoffmann, E.; Cech, G. M.; Kloska, A.; Hebraud, P.; Beyer, N.; Busi, F.; Grange, W.
10.1101/2022.09.09.507109 — molecular biology — Posted on 2022-09-15
2395 Modeling communication and switching nonlinear dynamics in multi-region neural activity
Karniol-Tambour, O.; Zoltowski, D. M.; Diamanti, E. M.; Pinto, L.; Tank, D. W.; Brody, C. W.; Pillow, J. W.
10.1101/2022.09.13.507841 — neuroscience — Posted on 2022-09-15
2396 Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming.
Keine, C.; Al-Yaari, M.; Radulovic, T.; Thomas, C. I.; Valino Ramos, P.; Guerrero-Given, D.; Ranjan, M.; Taschenberger, H.; Kamasawa, N.; Young, S. M.
10.1101/2022.06.29.497712 — neuroscience — Posted on 2022-09-15
2399 Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness
Oropeza, E.; Punturi, S.; Carrel, S. J.; Mazumder, A.; Jimenez, A.; VandenHeuvel, S. N.; Noltensmeyer, D. A.; Punturi, N.; Lei, J. T.; Lim, B.; Raghavan, S.; Bainbridge, M.; Haricharan, S.
10.1101/2020.10.29.361352 — cancer biology — Posted on 2022-09-15
2401 Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy
ZHU, D.; Brookes, D. H.; Busia, A.; Carneiro, A.; Fannjiang, C.; Popova, G.; Shin, D.; Chang, E. F.; Nowakowski, T. J.; Listgarten, J.; Schaffer, D. V.
10.1101/2021.11.02.467003 — bioengineering — Posted on 2022-09-15
2403 Human commensal Candida albicans strains demonstrate substantial within-host diversity and retained pathogenic potential
Anderson, F. M.; Visser, N.; Amses, K.; Hodgins-Davis, A.; Weber, A. M.; Metzner, K. M.; McFadden, M. J.; Mills, R. E.; O'Meara, M. J.; James, T. Y.; OMeara, T. R.
10.1101/2022.09.09.507247 — microbiology — Posted on 2022-09-15
2411 Genomic analysis of extended-spectrum beta-lactamase (ESBL) producing Escherichia coli colonising adults in Blantyre, Malawi reveals previously undescribed diversity.
Lewis, J. M.; Mphasa, M.; Banda, R.; Beale, M. A.; Mallewa, J.; Anscombe, C.; Zuza, A.; Roberts, A. P.; Heinz, E.; Thomson, N. R.; Feasey, N. A.
10.1101/2021.10.07.463523 — microbiology — Posted on 2022-09-15
2413 Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
O'Brien, D. P.; Jones, H. B.; Guenther, F.; Murphy, E. J.; England, K. S.; Anderson, M.; Brennan, P.; Davis, J. B.; Pinto-Fernandez, A.; Turnbull, A. P.; Kessler, B. M.
10.1101/2022.09.13.507798 — biochemistry — Posted on 2022-09-15
2414 Defining Cardiac Recovery at Single Cell Resolution
Amrute, J. M.; Lai, L.; Ma, P.; Koenig, A. L.; Kamimoto, K.; Bredemeyer, A.; Shankar, T. S.; Kuppe, C.; Kadyrov, F. F.; Schulte, L. J.; Stoutenburg, D.; Kopecky, B. J.; Navankasattusas, S.; Visker, J.; Morris, S. A.; Kramann, R.; Leuschner, F.; Mann, D. L.; Drakos, S. G.; Lavine, K. J.
10.1101/2022.09.11.507463 — genomics — Posted on 2022-09-15
2417 Convergent community assembly among globally separated acidic cave biofilms
Jones, D. S.; Schaperdoth, I.; Northup, D. E.; Gomez-Cruz, R.; Macalady, J.
10.1101/2022.09.13.507874 — microbiology — Posted on 2022-09-15
2419 Metadata preservation and stewardship for genomic data is possible, but must happen now
Crandall, E. D.; Toczydlowski, R. H.; Liggins, L.; Holmes, A. E.; Ghoojaei, M.; Gaither, M. R.; Wham, B. E.; Pritt, A. L.; Noble, C.; Anderson, T. J.; Barton, R. L.; Berg, J. T.; Beskid, S. G.; Delgado, A.; Farrell, E.; Himmelsbach, N.; Queeno, S. R.; Trinh, T.; Weyand, C. A.; Bentley, A.; Deck, J.; Riginos, C.; Bradburd, G. S.; Toonen, R. J.
10.1101/2022.09.12.507034 — bioinformatics — Posted on 2022-09-15
2421 Pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction
Ledwitch, K. V.; Kuenze, G.; Larochelle, K.; Okwei, E. N. N.; Pankewitz, L.; Ganguly, S.; Darling, H. L.; Coin, I.; Meiler, J.
10.1101/2022.09.14.507970 — biophysics — Posted on 2022-09-15
2422 Molecular elucidation of drug-induced abnormal assemblies of the Hepatitis B Virus capsid protein by solid-state NMR
Lecoq, L.; Brigandat, L.; Huber, R.; Fogeron, M.-L.; Callon, M.; Malaer, A.; Wang, S.; Dujardin, M.; Briday, M.; Wiegand, T.; Durantel, D.; Burdette, D.; Berke, J.-M.; Meier, B. H.; Nassal, M.; Bockmann, A.
10.1101/2022.09.14.507909 — biophysics — Posted on 2022-09-15
2425 Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis
Zhong, Z.; Wang, Y.; Wang, M.; Yang, F.; Thomas, Q. A.; Xue, Y.; Zhang, Y.; Liu, W.; Jami-Alahmadi, Y.; Xu, L.; Feng, S.; Marquardt, S.; Wohlschlege, J. A.; Ausin, I.; Jacobsen, S. E.
10.1101/2022.09.12.507673 — plant biology — Posted on 2022-09-15
2428 Binding of ATP to GroEL: a Case for Variable-Temperature Native Mass Spectrometry Thermodynamic Studies
Walker, T.; Sun, H. M.; Gunnels, T.; Wysocki, V.; Laganowsky, A.; Rye, H.; Russell, D. H.
10.1101/2022.09.13.507831 — biophysics — Posted on 2022-09-15
2429 Multiscale compression-induced restructuring of stacked lipid bilayers: from buckling delamination to molecular packing
Porras-Gomez, M.; Kim, H.; Dronadula, M. T.; Kambar, N.; Metellus, C. J. P.; Aluru, N. R.; van der Zande, A.; Leal, C.
10.1101/2022.09.12.507641 — biophysics — Posted on 2022-09-15
2431 Expanding the repertoire of human tandem repeat RNA-binding proteins
Ormazabal, A.; Carletti, M. S.; Saldano, T. E.; Gonzalez-Buitron, M.; Marchetti, J.; Palopoli, N.; Bateman, A.
10.1101/2022.09.12.507642 — bioinformatics — Posted on 2022-09-15
2432 ACCELERATING ANTIBODY DESIGN WITH ACTIVE LEARNING
Seo, S.-w.; Kwak, M. W.; Kang, E.; Kim, C.; Park, E.; Kang, T. H.; Kim, J.
10.1101/2022.09.12.507690 — bioengineering — Posted on 2022-09-15
2435 Deficits in cerebellum-dependent learning and cerebellar morphology in male and female BTBR autism model mice
Kiffmeyer, E. A.; Cosgrove, J. A.; Siganos, J. K.; Bien, H. E.; Vipond, J. E.; Vogt, K. R.; Kloth, A. D.
10.1101/2022.09.14.507695 — neuroscience — Posted on 2022-09-15
2436 Elucidating polymorphs of crystal structures with intensity-based hierarchical clustering analysis on multiple diffraction datasets
Matsuura, H.; Sakai, N.; Toma-Fukai, S.; Muraki, N.; Hayama, K.; Kamikubo, H.; Aono, S.; Kawano, Y.; Yamamoto, M.; Hirata, K.
10.1101/2022.09.13.507775 — molecular biology — Posted on 2022-09-14
2439 Viroscope: plant viral diagnosis from NGS data using biologically-informed genome assembly coverage
Valenzuela, S. L.; Norambuena, T.; Morgante, V.; Garcia, F.; Jimenez, J. C.; Nunez, C.; Fuentes, I.; Pollak, B.
10.1101/2022.09.14.507814 — microbiology — Posted on 2022-09-14
2440 IL-1β turnover by TRIP12 and AREL1 ubiquitin ligases and UBE2L3 limits inflammation
Mishra, V.; Crespo-Puig, A.; McCarthy, C.; Masonou, T.; Glegola-Madejska, I.; Dejoux, A.; Dow, G.; Eldridge, M. J. G.; Marinelli, L. H.; Meng, M.; Wang, S.; Bennison, D. J.; Shenoy, A. R.
10.1101/2022.09.14.507790 — immunology — Posted on 2022-09-14
2446 Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues
Qiu, D.; Gu, C.; Liu, G.; Ritter, K.; Eisenbeis, V. B.; Bittner, T.; Gruzdev, A.; Seidel, L.; Bengsch, B.; Shears, S. B.; Jessen, H.
10.1101/2022.09.14.507917 — biochemistry — Posted on 2022-09-14
2453 Novel lipid biomarkers for algal resistance to viral infection in the ocean
Schleyer, G.; Kuhlisch, C.; Ziv, C.; Ben-Dor, S.; Malitsky, S.; Schatz, D.; Vardi, A.
10.1101/2022.09.14.507897 — microbiology — Posted on 2022-09-14
2457 Structure-Function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct symbiotic cues supporting Drosophila juvenile growth
Nikolopoulos, N.; Matos, R. C.; Ravaud, S.; Courtin, P.; Akherraz, H.; Palussiere, S.; Gueguen-Chaignon, V.; Salomon-Mallet, M.; Guillot, A.; Guerardel, Y.; Chapot-Chartier, M.-P.; Grangeasse, C.; Leulier, F.
10.1101/2022.09.14.507969 — microbiology — Posted on 2022-09-14
2458 Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa
Pajon, C.; Fortoul, M. C.; Diaz-Tang, G.; Meneses, E. M.; Mariah, T.; Toscan, B.; Marcelin, M.; Lopatkin, A. J.; Eldakar, O. T.; Smith, R. P.
10.1101/2022.09.14.507888 — microbiology — Posted on 2022-09-14
2459 pWCP is a widely distributed and highly conserved Wolbachia plasmid in Culex mosquitoes worldwide
Ghousein, A.; Tutagata, J.; Etienne, M.; Chaumeau, V.; Boyer, S.; Pages, N.; Roiz, D.; Eren, A. M.; Cambray, G.; Reveillaud, J.
10.1101/2022.09.14.507914 — microbiology — Posted on 2022-09-14
2461 Leishmania amazonensis controls macrophage-regulated cell death to establish chronic infection in vitro and in vivo
Lecoeur, H.; Zhang, S.; Varet, H.; Legendre, R.; Proux, C.; Granjean, C.; Bousso, P.; Prina, E.; Spaeth, G. F.
10.1101/2022.09.14.507851 — microbiology — Posted on 2022-09-14
2462 The Diversity and Ubiquity of Antibiotic Resistant Genes in Finfish Culture Ponds in Bangladesh
Bell, A. G.; Thornber, K.; Chaput, D. L.; Hasan, N. A.; Alam, M. M.; Haque, M. M.; Cable, J.; Temperton, B.; Tyler, C. R.
10.1101/2022.09.14.507951 — microbiology — Posted on 2022-09-14
2463 Structural evolution of an immune evasion determinant shapes Lyme borreliae host tropism
Marcinkiewicz, A. L.; Brangulis, K.; Dupuis, A. P.; Hart, T. M.; Zamba_Campero, M.; Nowak, T. A.; Stout, J. L.; Akopjana, I.; Kazaks, A.; Bogans, J.; Ciota, A. T.; Kraiczy, P.; Kolokotronis, S.-O.; Lin, Y.-P.
10.1101/2022.09.13.507797 — microbiology — Posted on 2022-09-14
2464 Systematically attenuating DNA targeting enables CRISPR-driven editing in bacteria
Collias, D.; Vialetto, E.; Yu, J.; Co, K.; Almasi, E.; Ruettiger, A.-S.; Achmedov, T.; Strowig, T.; Beisel, C. L.
10.1101/2022.09.14.507927 — synthetic biology — Posted on 2022-09-14
2466 Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants
Rodriguez-Aponte, S. A.; Dalvie, N. C.; Wong, T. Y.; Johnston, R. S.; Naranjo, C. A.; Bajoria, S.; Kumru, O. S.; Kaur, K.; Russ, B. P.; Lee, K. S.; Cyphert, H. A.; Barbier, M.; Rao, H. D.; Rajurkar, M. P.; Lothe, R. R.; Shaligram, U.; Batwal, S.; Chandrasekaran, R.; Nagar, G.; Kleanthous, H.; Biswas, S.; Bevere, J. R.; Joshi, S. B.; Volkin, D. B.; Damron, F. H.; Love, J. C.
10.1101/2022.09.14.507842 — bioengineering — Posted on 2022-09-14
2467 EukProt: A database of genome-scale predicted proteins across the diversity of eukaryotes
Richter, D. J.; Berney, C.; Strassert, J. F. H.; Poh, Y.-P.; Herman, E. K.; Munoz-Gomez, S. A.; Wideman, J. A.; Burki, F.; de Vargas, C.
10.1101/2020.06.30.180687 — evolutionary biology — Posted on 2022-09-14
2468 Variation in mutation, recombination, and transposition rates in Drosophila melanogaster and Drosophila simulans
Wang, Y.; McNeil, P.; Abdulazeez, R.; Pascual, M.; Johnston, S. E.; Keightley, P. D.; Obbard, D. J.
10.1101/2022.09.12.507595 — evolutionary biology — Posted on 2022-09-14
2469 PARNAS: Objectively Selecting the Most Representative Taxa on a Phylogeny
Markin, A.; Wagle, S.; Grover, S.; Vincent Baker, A. L.; Eulenstein, O.; Anderson, T. K.
10.1101/2022.09.12.507613 — evolutionary biology — Posted on 2022-09-14
2470 MATEdb, a data repository of high-quality metazoan transcriptome assemblies to accelerate phylogenomic studies
Fernandez, R.; Tonzo, V.; Simon Guerrero, C.; Lozano-Fernandez, J.; Martinez-Redondo, G. I.; Balart-Garcia, P.; Aristide, L.; Eleftheriadi, K.; Vargas-Chavez, C.
10.1101/2022.07.18.500182 — evolutionary biology — Posted on 2022-09-14
2472 The SARS-CoV-2 spike N-terminal domain engages 9-O-acetylated α2-8-linked sialic acids
Tomris, I.; Unione, L.; Nguyen, L.; Zaree, P.; Bouwman, K. M.; Liu, L.; Li, Z.; Fok, J. A.; Rios Carrasco, M.; van der Woude, R.; Kimpel, A. L. M.; Linthorst, M. W.; Verpalen, E. C. J. M.; Caniels, T. G.; Sanders, R. W.; Heesters, B. A.; Pieters, R. J.; Jimenez-Barbero, J.; Klassen, J. S.; Boons, G.-J.; de Vries, R. P.
10.1101/2022.09.14.507904 — molecular biology — Posted on 2022-09-14
2473 A novel fluorobenzothiazole RBx 10080758 as a dual inhibitor against bacterial GyraseB (GyrB) and Topoisomerase IV (parE) of Gram-positive pathogens causing skin and respiratory infections
Barman, T.; Kumar, M.; Chaira, T.; Singhal, S.; Mathur, T.; Kalia, V.; Gangadharan, R.; Rao, M.; Pandya, M.; Bhateja, P.; Sood, R.; Upadhyay, D.; Varughese, S.; Yadav, A.; Sharma, L.; Kumar, N.; Sattigeri, J.; Bhatnagar, P. K.; Raj, V. S.
10.1101/2022.09.08.507076 — microbiology — Posted on 2022-09-14
2474 HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era
Buhler, S.; Calderin, Z.; Bettens, F.; Schaefer, A.; Dantin, C.; Ansari, M.; Mamez, A.-C.; Masouridi-Levrat, S.; Chalandon, Y.; Ferrari-Lacraz, S.; Villard, J.
10.1101/2022.09.14.507948 — immunology — Posted on 2022-09-14
2475 Structure and Epitope of a Neutralizing Monoclonal Antibody that Targets the Stem Helix of β Coronaviruses
Deshpande, A.; Schormann, N.; Piepenbrink, M. S.; Martinez-Sobrido, L.; Kobie, J.; Walter, M. R.
10.1101/2022.09.14.507947 — immunology — Posted on 2022-09-14
2476 Monocyte-derived peritoneal macrophages protect C57BL/6 mice against surgery-induced adhesions
Sahputra, R.; Dejyong, K.; Woolf, A.; Mack, M.; Allen, J. E.; Ruckerl, D.; Herrick, S.
10.1101/2022.07.12.499772 — immunology — Posted on 2022-09-14
2477 A method to estimate the cellular composition of the mouse brain from heterogeneous datasets
Rodarie, D.; Veraszto, C.; Roussel, Y.; Reimann, M.; Keller, D.; Ramaswamy, S.; Markram, H.; Gewaltig, M.-O.
10.1101/2021.11.20.469384 — neuroscience — Posted on 2022-09-14
2478 Validation and Establishment of a SARS-CoV-2 Lentivirus Surrogate Neutralization Assay as a pre-screening tool for the Plaque Reduction Neutralization Test
Merluza, J.; Ung, J.; Makowski, K.; Robinson, A.; Manguiat, K. J.; Mueller, N.; Audet, J.; Chen, J. C.-y.; Strong, J. E.; Wood, H.; Bello, A.
10.1101/2022.09.13.507876 — scientific communication and education — Posted on 2022-09-14
2479 Jovian enables direct inference of germline haplotypes from short reads via sequence-to-sequence modeling
O'Fallon, B. D.; Bolia, A.; Durtschi, J.; Yang, L.; Noble, K.; Frederickson, E.; Best, H.; Coleman, J.
10.1101/2022.09.12.506413 — bioinformatics — Posted on 2022-09-14
2482 The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution
Moulana, A.; Dupic, T.; Phillips, A. M.; Chang, J.; Roffler, A. A.; Greaney, A. J.; Starr, T. N.; Bloom, J. D.; Desai, M. M.
10.1101/2022.09.13.507781 — evolutionary biology — Posted on 2022-09-14
2483 Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
Romitti, M.; Tourneur, A.; de Faria da Fonseca, B.; Doumont, G.; Gillotay, P.; Liao, x.-h.; Eski, S. E.; Van Simaeys, G.; Chomette, L.; Lasolle, h.; Monestier, O.; Figini Kasprzyk, D.; Detours, V.; Singh, S. P.; Goldman, S.; Refetoff, S.; Costagliola, S.
10.1101/2021.12.01.470729 — developmental biology — Posted on 2022-09-14
2484 An Arp2/3-cPLA2-NFkB axis acts as a Cell Shape Sensor to drive Homeostatic Migration of Dendritic Cells
Alraies, Z.; Rivera, C. A.; Delgado, M.-G.; Sanseau, D.; Maurin, M.; Yatim, A.; Saez, P.; Williart, A.; Gratia, M.; DeSilva, N.; Moreau, A.; Albaud, B.; Legoix, P.; Nakano, H.; Cook, D. N.; Lawrence, T.; Manel, N.; D. Moreau, H.; Nader, G. P. F.; Piel, M.; Lennon-Dumenil, A.-M.
10.1101/2022.08.09.503223 — cell biology — Posted on 2022-09-14
2485 Nanobody engineering for SARS-CoV-2 neutralization and detection
Hannula, L.; Kuivanen, S.; Lasham, J.; Kant, R.; Kareinen, L.; Bogacheva, M.; Strandin, T.; Sironen, T.; Sharma, V.; Saviranta, P.; Kipar, A.; Vapalahti, O.; Huiskonen, J. T.; Rissanen, I.
10.1101/2022.09.14.507920 — microbiology — Posted on 2022-09-14
2486 Trans-synaptic dwelling of SARS-CoV-2 particles perturbs neural synapse organization and function
Partiot, E.; Hirschler, A.; Colomb, S.; Lutz, W.; Claeys, T.; Delalande, F.; Deffieu, M. S.; Roels, J.; Bons, J.; Callon, D.; Andreoletti, L.; Labrousse, M.; Jacobs, F. M.; Rigau, V.; Charlot, B.; Martens, L.; Carapito, C.; Ganesh, G.; Gaudin, R.
10.1101/2022.09.13.507484 — microbiology — Posted on 2022-09-14
2488 Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses
Strine, M. S.; Cai, W. L.; Wei, J.; Alfajaro, M. M.; Filler, R. B.; Biering, S. B.; Sarnik, S.; Patil, A.; Cervantes, K. S.; Collings, C. K.; DeWeirdt, P. C.; Hanna, R. E.; Schofield, K.; Hulme, C.; Konermann, S.; Doench, J. G.; Hsu, P. D.; Kadoch, C.; Yan, Q.; Wilen, C. B.
10.1101/2022.09.13.507833 — microbiology — Posted on 2022-09-14
2495 Maize integrates light and volatile cues from neighboring plants into unique defense responses
Escobar-Bravo, R.; Schimmel, B. C.; Zhang, Y.; Robert, C. A.; Glauser, G.; Ballare, C. L.; Erb, M.
10.1101/2022.09.12.507519 — plant biology — Posted on 2022-09-14
2498 SARS-CoV-2 Protein Nsp2 Stimulates Translation Under Normal and Hypoxic Conditions
Korneeva, N.; Khalil, M. I.; Ghosh, i.; Fan, R.; Arnold, T.; De Benedetti, A.
10.1101/2022.09.13.507829 — physiology — Posted on 2022-09-14
2499 Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibits small-cell lung cancer growth without causing on-target toxicities in mice
KHAN, S.; Kellish, P.; Connis, N.; Thummuri, D.; Wiegand, J.; Zhang, P.; Zhang, X.; Budamagunta, V.; Hua, N.; Yang, Y.; De, U.; Jin, L.; Zhang, W.; Zheng, G.; Hromas, R.; Hann, C.; Zajac-Kaye, M.; Kaye, F. J.; Zhou, D.
10.1101/2022.09.12.507616 — cancer biology — Posted on 2022-09-14
2501 CimpleG: Finding simple CpG methylation signatures
Maie, T.; Schmidt, M.; Erz, M.; Wagner, W.; Gesteira Costa Filho, I.
10.1101/2022.09.12.507513 — bioinformatics — Posted on 2022-09-14
2503 Modelling group heteroscedasticity in single-cellRNA-seq pseudo-bulk data
You, Y.; Dong, X.; Wee, Y. K.; Maxwell, M. J.; Alhamdoosh, M.; Smyth, G.; Hickey, P. F.; Ritchie, M. E.; Law, C. W.
10.1101/2022.09.12.507511 — bioinformatics — Posted on 2022-09-14
2504 Measuring Capillary Flow Dynamics using Interlaced Two-Photon Volumetric Scanning
Giblin, J.; Park, S.-W.; Jiang, J.; Kilic, K.; Kura, S.; Boas, D. A.; Chen, I. A.
10.1101/2022.09.12.507580 — bioengineering — Posted on 2022-09-14
2505 Photoselective sequencing: microscopically-guided genomic measurements with subcellular resolution
Mangiameli, S. M.; Chen, H.; Earl, A. S.; Dobkin, J.; Lesman, D.; Buenrostro, J. D.; Chen, F.
10.1101/2022.09.12.507600 — genomics — Posted on 2022-09-14
2512 An Arrayed Transposon Library of Ruegeria pomeroyi DSS-3
Mejia, C.; Trujillo Rodriguez, L.; Poudel, R.; Ellington, A.; Rivers, A. R.; Reisch, C.
10.1101/2022.09.11.507510 — microbiology — Posted on 2022-09-14
2513 Developmental instability of CA1 pyramidal cells in Dravet Syndrome
P. Jones, S.; O'Neill, N.; Muggeo, S.; Colasante, G.; Kullmann, D. M.; Lignani, G.
10.1101/2022.09.12.507264 — neuroscience — Posted on 2022-09-14
2514 Action prediction error: a value-free dopaminergic teaching signal that drives stable learning
Greenstreet, F.; Vergara, H. M.; Pati, S.; Schwarz, L.; Wisdom, M.; Marbach, F.; Johansson, Y.; Rollik, L.; Moskovitz, T.; Clopath, C. M.; Stephenson-Jones, M.
10.1101/2022.09.12.507572 — neuroscience — Posted on 2022-09-14
2518 Quantification of membrane binding and diffusion using Fluorescence Correlation Spectroscopy diffusion laws
Mouttou, A.; Bremaud, E.; Noero, J.; Dibsy, R.; Arone, C.; Mak, J.; MURIAUX, D.; Berry, H.; Favard, C.
10.1101/2022.09.12.507540 — biophysics — Posted on 2022-09-14
2522 ARTseq-FISH reveals position-dependent fate decisions driven by cell cycle changes
Hu, X.; van Sluijs, B.; Garcia Blay, O.; Stepanov, Y.; Rietrae, K.; Huck, W.; Hansen, M. M. K.
10.1101/2022.09.14.507902 — systems biology — Posted on 2022-09-14
2523 Measuring the similarity of SMLM-derived point-clouds
Baragilly, M.; Nieves, D.; Williamson, D.; Peters, R.; Owen, D.
10.1101/2022.09.12.507560 — biophysics — Posted on 2022-09-14
2530 Evolutionary trajectories are contingent on mitonuclear interactions
Biot-Pelletier, D.; Bettinazzi, S.; Gagnon-Arsenault, I.; Dube, A. K.; Bedard, C.; Nguyen, T. H. M.; Fiumera, H.; Breton, S.; Landry, C.
10.1101/2022.09.11.507487 — evolutionary biology — Posted on 2022-09-14
2531 Neutrophils regulate ITPR2 levels in epithelia by direct injection of elastase
Ogino, N.; Leite, M. F.; Kruglov, E.; Asashima, H.; Hafler, D. A.; Ehrlich, B. E.; Nathanson, M.
10.1101/2022.09.13.506588 — cell biology — Posted on 2022-09-14
2541 The sequence compositional complexity of the coronavirus decays over pandemic time
Oliver, J. L.; Bernaola-Galvan, P.; Perfectti, F.; Gomez-Martin, C.; Castiglione, S.; Raia, P.; Verdu, M.; Moya, A.
10.1101/2021.11.06.467547 — genomics — Posted on 2022-09-14
2543 SARS-CoV-2 hijacks p38β/MAPK11 to promote viral protein translation
Higgins, C. A.; Nilsson-Payant, B. E.; Kurland, A.; Ye, C.; Yaron, T. M.; Johnson, J. L.; Bonaventure, B.; Adhikary, P.; Golynker, I.; Rosenberg, B. R.; Danziger, O.; Panis, M.; Cantley, L. C.; Martinez-Sobrido, L.; tenOever, B. R.; Johnson, J. R.
10.1101/2021.08.20.457146 — microbiology — Posted on 2022-09-14
2546 Paecilomycone inhibits quorum sensing in Gram-negative bacteria
Beenker, W. A.; Hoeksma, J.; Marie Bannier-Helaouët, M.; Clevers, H.; den Hertog, J.
10.1101/2022.09.12.507720 — microbiology — Posted on 2022-09-14
2547 Hydrogen Peroxide Production by Epidermal Dual Oxidase 1 Regulates Nociceptive Sensory Signals
Pato, A.; Bölcskei, K.; Donko, A.; Kaszas, D.; Boros, M.; Bodrogi, L.; Varady, G.; Pape, V. F.; Roux, B.; Enyedi, B.; Helyes, Z.; Watt, F. M.; Sirokmany, G.; Geiszt, M.
10.1101/2022.09.11.507480 — physiology — Posted on 2022-09-14
2548 Quantum Biology in Cellular Migration
Vecheck, A.; McNamee, C.; Reijo Pera, R. A.; Usselman, R.
10.1101/2022.09.09.507322 — biophysics — Posted on 2022-09-14
2550 Experimental evaluation of environmental DNA methods for detection of a rare fish in turbid water
Holmes, A. E.; Baerwald, M. R.; Rodzen, J. A.; Schreier, B. M.; Mahardja, B.; Finger, A. J.
10.1101/2022.08.24.502857 — molecular biology — Posted on 2022-09-14
2553 Hourglass, a tool to mine bioimaging data, uncovers sex-disparities in the IL-6-associated T cell response in pancreatic tumors
Aliar, K.; Waterhouse, H. R.; Vyas, F.; Krebs, N.; Poulton, E.; Zhang, B.; Chan, N.; Bronsert, P.; Fischer, S. E.; Gallinger, S.; Grünwald, B. T.; Khokha, R.
10.1101/2022.09.12.507618 — cancer biology — Posted on 2022-09-14
2554 Fluorescence Lifetime: Beating the IRF and interpulse window
Fazel, M.; Vallmitjana, A.; Scipioni, L.; Gratton, E.; Digman, M. A.; Presse, S.
10.1101/2022.09.08.507224 — biophysics — Posted on 2022-09-14
2560 Genomic evidence of natural selection for ash dieback resistance
Metheringham, C. L.; Plumb, W.; Stocks, J.; Kelly, L.; Nemesio Gorriz, M.; Moat, J.; Buggs, R.; Nichols, R. A.
10.1101/2022.08.01.502033 — evolutionary biology — Posted on 2022-09-14
2562 Homeostatic Synaptic Plasticity Rescues Neural Coding Reliability
Rozenfeld, E.; Ehmann, N.; Manoim, J. E.; Kittel, R.; Parnas, M.
10.1101/2021.12.06.471391 — neuroscience — Posted on 2022-09-14
2565 Long-distance linguistic dependencies in Chinese and English brains
Dunagan, D.; Stanojevic, M.; Coavoux, M.; Zhang, S.; Bhattasali, S.; Li, J.; Brennan, J.; Hale, J. T.
10.1101/2022.09.12.507571 — neuroscience — Posted on 2022-09-14
2568 Mapping the Constrained Coding Regions in the human genome to their corresponding proteins
Hasenahuer, M. A.; Sanchis-Juan, A.; Laskowski, R. A.; Baker, J. A.; Stephenson, J. D.; Orengo, C. A.; Raymond, F. L.; Thornton, J. M.
10.1101/2022.09.12.507545 — bioinformatics — Posted on 2022-09-14
2571 The catheterized bladder environment promotes Efg1- and Als1-dependent Candida albicans infection
La Bella, A. A.; Andersen, M. J.; Gervais, N.; Molina, J. J.; Molesan, A.; Stuckey, P. V.; Wensing, L.; Nobile, C. J.; Shapiro, R. S.; Santiago-Tirado, F. H.; Flores-Mireles, A. L.
10.1101/2021.06.01.446547 — microbiology — Posted on 2022-09-14
2572 Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicans
Gervais, N. C.; La Bella, A. A.; Wensing, L. F.; Sharma, J.; Acquaviva, V.; Best, M.; Cadena Lopez, R. O.; Fogal, M.; Uthayakumar, D.; Chavez, A.; Santiago-Tirado, F.; Flores-Mireles, A. L.; Shapiro, R. S.
10.1101/2022.08.15.501889 — microbiology — Posted on 2022-09-14
2573 Cell-free Protein Crystallization for Nanocrystal Structure Determination
Abe, S.; Tanaka, J.; Kojima, M.; Kanamaru, S.; Hirata, K.; Yamashita, K.; Kobayashi, A.; Ueno, T.
10.1101/2022.04.15.488232 — biophysics — Posted on 2022-09-14
2576 Role of UCP2 in the energy metabolism of the cancer cell line A549
Segales, J.; Sanchez-Martin, C.; Pujol, A.; Martin-Ruiz, M.; Rial, E.
10.1101/2022.09.13.507778 — biochemistry — Posted on 2022-09-13
2578 Biosynthesis of iridoid sex pheromones in aphids
Koellner, T. G.; David, A.; Luck, K.; Beran, F.; Kunert, G.; Zhou, J.-J.; Caputi, L.; O'Connor, S. E.
10.1101/2022.09.13.507830 — biochemistry — Posted on 2022-09-13
2579 MATR3-antisense LINE1 RNA meshwork scaffolds higher-order chromatin organization
Zhang, Y.; Cao, X.; Gao, Z.; Ma, X.; Wang, Q.; Cai, X.; Zhang, Y.; Zhang, Z.; Wei, G.; Wen, B.
10.1101/2022.09.13.506124 — cell biology — Posted on 2022-09-13
2585 Recycling upstream redox enzymes expands the regioselectivity of cycloaddition in pseudo-aspidosperma alkaloid biosynthesis
Kamileen, M. O.; DeMars, M.; Hong, B.; Nakamura, Y.; Paetz, C.; Lichman, B. R.; Sonawane, P. D.; Caputi, L.; O'Connor, S. E.
10.1101/2022.09.13.507834 — biochemistry — Posted on 2022-09-13
2588 Metabolic Signatures of Performance in Elite World Tour Professional Cyclists
Nemkov, T.; Cendali, F.; Stefanoni, D.; Martinez, J.; Hansen, K. C.; San-Millan, I.; D'Alessandro, A.
10.1101/2022.09.13.507793 — biochemistry — Posted on 2022-09-13
2589 Single-cell transcriptomic profiling of kidney fibrosis identifies a novel specific fibroblast marker and putative disease target
Rudman-Melnick, V.; Adam, M.; Stowers, K.; Potter, A.; Ma, Q.; Chokshi, S. M.; Vanhoutte, D.; Valiente-Alandi, I.; Lindquist, D. M.; Nieman, M. L.; Kofron, J. M.; Potter, S. S.; Devarajan, P.
10.1101/2022.09.13.507855 — molecular biology — Posted on 2022-09-13
2592 Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
Miller, A. M.; Meehan, S.; Dobson, C. M.; Welland, M. E.; Klenerman, D.; Vendruscolo, M.; Ruggeri, F. S.; Knowles, T. P. J.
10.1101/2022.09.13.507729 — molecular biology — Posted on 2022-09-13
2593 ZMYM2 is essential for methylation of germline genes and active transposons in embryogenesis
Graham-Paquin, A.-L.; Saini, D.; Sirois, J.; Hossain, I.; Katz, M. S.; Zhuang, Q. K.-W.; Kwon, S. Y.; Yamanaka, Y. A.; Bourque, G.; Bouchard, M.; Pastor, W. A.
10.1101/2022.09.13.507699 — molecular biology — Posted on 2022-09-13
2599 SPRAY-INDUCED GENE SILENCING IDENTIFIES PATHOGEN PROCESSES CONTRIBUTING TO POWDERY MILDEW PROLIFERATION
McRae, A. G.; Taneja, J.; Yee, K.; Shi, X.; Haridas, S.; LaButti, K.; Singan, V.; Grigoriev, I. V.; Wildermuth, M. C.
10.1101/2022.09.13.507682 — microbiology — Posted on 2022-09-13
2601 Integrons, plasmids, and resistance genes in equine faecal bacteria
Mitchell, S.; Moran, R. A.; Elbourne, L.; Chapman, B.; Bull, M.; Muscatello, G.; Coleman, N. V.
10.1101/2022.09.12.507718 — microbiology — Posted on 2022-09-13
2603 Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
O'Brien, D. P.; Jones, H. B.; Guenther, F.; Murphy, E. J.; England, K. S.; Pinto-Fernandez, A.; Anderson, M.; Brennan, P.; Davis, J. B.; Turnbull, A. P.; Kessler, B. M.
10.1101/2022.09.13.507798 — biochemistry — Posted on 2022-09-13
2604 IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques
Nelson, C. E.; Foreman, T. W.; Kauffman, K. D.; Sakai, S.; Fleegle, J. D.; Gomez, F.; NIAID/DIR Tuberculosis Imaging Program, ; Le Nouen, C.; Liu, X.; Burdette, T. L.; Garza, N. L.; Lafont, B. A. P.; Brooks, K.; Arlehamn, C. S. L.; Weiskopf, D.; Sette, A.; Hickman, H. D.; Buchhholz, U. J.; Johnson, R. F.; Brenchley, J. M.; Via, L. E.; Barber, D. L.
10.1101/2022.09.13.507852 — immunology — Posted on 2022-09-13
2606 Nitrogen availability and plant functional composition modify biodiversity-multifunctionality relationships
Pichon, N. A.; Cappelli, S. L.; Soliveres, S.; Mannall, T.; Nwe, T. Z.; Hölzel, N.; Klaus, V. H.; Kleinebecker, T.; Vincent, H.; Allan, E.
10.1101/2020.08.17.254086 — ecology — Posted on 2022-09-13
2608 Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant
Scheaffer, S. M.; Lee, D.; Whitener, B.; Ying, B.; Wu, K.; Jani, H.; Martin, P.; Amato, N. J.; Avena, L. E.; Berrueta, D. M.; Schmidt, S. D.; O'Dell, S.; Nasir, A.; Chuang, G.-Y.; Stewart-Jones, G.; Koup, R. A.; Doria-Rose, N. A.; Carfi, A.; Elbashir, S. M.; Thackray, L. B.; Edwards, D. K.; Diamond, M. S.
10.1101/2022.09.12.507614 — microbiology — Posted on 2022-09-13
2609 Monitoring correlates of SARS-CoV-2 infection in cell culture using two-photon microscopy and a novel fluorescent calcium-sensitive dye
Domokos, M.; Szalay, G.; Cseri, L.; Kis, Z.; Palyi, B.; Foldes, G.; Kovacs, N.; Fulop, A.; Szepesi, A.; Hajdrik, P.; Csomos, A.; Zsembery, A.; Kadar, K.; Katona, G.; Mucsi, Z.; Rozsa, B. J.; Kovacs, E.
10.1101/2022.09.12.506773 — microbiology — Posted on 2022-09-13
2610 Comparative multi-OMICS single-cell atlas of five COVID-19 (rAdVV and mRNA) vaccines describe unique and distinct mechanisms of action
Singh, Y.; Schulze-Selting, A.; Gabernet, G.; Ray, U.; Bajaj, R.; Ali, M.; Loitz, M.; Hammer, V.; Buena-Atienza, E.; Ruschil, C.; Huebner, J.; Kowarik, M.; salker, M.; Casadei, N.; Nahnsen, S.; Kremsner, P.; Ossowski, S.; Altmann, D. M.; Deutsche COVID-19 OMICS Initiative (DeCOI), ; Riess, O.
10.1101/2022.09.12.507666 — immunology — Posted on 2022-09-13
2612 Evaluation of endogenous and therapeutic 25-hydroxycholesterols in murine models of pulmonary SARS-CoV-2 infection
Fessler, M. B.; Madenspacher, J.; Baker, P. J.; Hilligan, K. L.; Castro, E.; Meacham, J.; Chen, S.-H.; Johnson, R. F.; Martin, N. P.; Tucker, C. J.; Mahapatra, D.; Cesta, M.; Mayer-Barber, K. D.
10.1101/2022.09.12.507671 — immunology — Posted on 2022-09-13
2613 Assembling highly repetitive Xanthomonas TALomes using Oxford Nanopore sequencing
Erkes, A.; Grove, R.; Zarkovic, M.; Krautwurst, S.; Koebnik, R.; Morgan, R. D.; Wilson, G. G.; Hölzer, M.; Marz, M.; Boch, J.; Grau, J.
10.1101/2022.08.17.504259 — bioinformatics — Posted on 2022-09-13
2615 A cortico-collicular circuit for accurate orientation to shelter during escape
Campagner, D.; Vale, R.; Tan, Y. L.; Iordanidou, P.; Arocas, O. P.; Claudi, F.; Stempel, A. V.; Keshavarzi, S.; Petersen, R.; Margrie, T.; Branco, T.
10.1101/2020.05.26.117598 — neuroscience — Posted on 2022-09-13
2617 Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection
Mikaeloff, F.; Gelpi, M.; Benfeitas, R.; Knudsen, A. D.; Vestad, B.; Hogh, J.; Hov, J.; Benfield, T.; Murray, D.; Giske, C. G.; Mardinoglu, A.; Troseid, M.; Poulsen, S. D.; Neogi, U.
10.1101/2022.06.08.495246 — bioinformatics — Posted on 2022-09-13
2620 The relationship between spectral and plant diversity: disentangling the influence of metrics and habitat types
Perrone, M.; Di Febbraro, M.; Conti, L.; Divisek, J.; Chytry, M.; Keil, P.; Carranza, M. L.; Rocchini, D.; Torresani, M.; Moudry, V.; Simova, P.; Prajzlerova, D.; Müllerova, J.; Wild, J.; Malavasi, M.
10.1101/2022.09.05.506583 — ecology — Posted on 2022-09-13
2621 Mitochondrial Derived Vesicles retain membrane potential and contain a functional ATP synthase
Hazan (Ben-Menachem), R.; Lintzer, D.; Ziv, T.; Das, K.; Rosenhek-Goldian, I.; Porat, Z.; Ben Ami Pilo, H.; Karniely, S.; Saada, A.; Regev-Rudzki, N.; Pines, O.
10.1101/2022.07.10.499450 — cell biology — Posted on 2022-09-13
2622 Sensory convergence and inhibitory divergence: deep dorsal horn inhibitory interneurons modulate the timing and magnitude of limb coordination during locomotion.
Ozeri-Engelhard, N.; Gradwell, M. A.; Laflamme, O. D.; Upadhyay, A.; Aoki, A.; Shrier, T.; Gandhi, M.; Gonzalez, M.; Eisdorfer, J. T.; Abbas- Zadeh, G.; Yusuf, N.; Imtiaz, Z.; Alomary, S.; Katz, J.; Haas, M.; Hernandez, Y.; Akay, T.; Abraira, V. E.
10.1101/2022.05.21.492933 — neuroscience — Posted on 2022-09-13
2627 Development of a new 3D tracking system for multiple marmosets under free-moving conditions
Yurimoto, T.; Kumita, W.; Sato, K.; Kikuchi, R.; Shibuki, Y.; Hashimoto, R.; Kamioka, M.; Hayasegawa, Y.; Yamazaki, E.; Kurotaki, Y.; Goda, N.; Kitakami, J.; Fujita, T.; Inoue, T.; Sasaki, E.
10.1101/2022.03.29.486138 — animal behavior and cognition — Posted on 2022-09-13
2632 Ehrlichia ruminantium uses its transmembrane protein Ape to adhere to host bovine aortic endothelial cells
Pinarello, V.; Bencurova, E.; Marcelino, I.; Gros, O.; Puech, C.; Bhide, M.; Vachiery, N.; MEYER, D. F.
10.1101/2021.06.15.447525 — microbiology — Posted on 2022-09-13
2633 Genetic deletion and pharmacologic inhibition of FcER1 reduces renal injury in mouse models of diabetic nephropathy.
Rashmi, P.; Silva, A. A.; Sigdel, T.; Damm, I.; Gouvea, A. L. F.; Koliwad, S.; Walavalkar, V.; Hakroush, S.; Sarwal, M. M.
10.1101/2022.09.10.507433 — immunology — Posted on 2022-09-13
2634 Tumor microenvironments impair T cell receptor affinity and function
Yuan, Z.; O'Melia, M. J.; Li, K.; Lyu, J.; Zhou, F.; Jothikumar, P.; Rohner, N. A.; Manspeaker, M. P.; Francis, D. M.; Bai, K.; Ge, C.; Rushdi, M. N.; Chingozha, L.; Ruiperez-Campillo, S.; Lu, H.; Thomas, S. N.; Zhu, C.
10.1101/2022.09.11.507496 — immunology — Posted on 2022-09-13
2641 Subjective assessment and taste strips testing of gustatory function, at home, and in the lab
Green, T.; Wolf, A.; Oleszkiewicz, A.; Aronis, A.; Hummel, T.; Pepino, M. Y.; Niv, M. Y.
10.1101/2022.09.11.507407 — physiology — Posted on 2022-09-13
2643 Genetic perturbation of MAPK11 (p38β) promotes radiosensitivity by enhancing IR-associated senescence.
Fernandez-Aroca, D. M.; Garcia-Flores, N.; Frost, S.; Jimenez-Suarez, J.; Rodriguez-Gonzalez, A.; Fernandez-Aroca, P.; Sabater, S.; Andres, I.; Garnes-Garcia, C.; Belandia, B.; Cimas, F. J.; Villar, D.; Ruiz-Hidalgo, M. J.; Sanchez-Prieto, R.
10.1101/2022.09.12.506954 — cancer biology — Posted on 2022-09-13
2644 Quantifying coexistence concentrations in multi-component phase-separating systems using analytical HPLC
Bremer, A.; Posey, A. E.; Borgia, M. B.; Borcherds, W. M.; Farag, M.; Pappu, R. V.; Mittag, T.
10.1101/2022.09.11.507495 — biophysics — Posted on 2022-09-13
2646 Designing DNA-based predictors of drug response using the signal joint with gene expression
Mourragui, S.; Loog, M.; van Nee, M.; van de Wiel, M. A.; Reinders, M.; Wessels, L.
10.1101/2022.09.11.507473 — bioinformatics — Posted on 2022-09-13
2652 Max is likely not at the Drosophila histone locus
Xie, M.; Comstra, H. S.; Schmidt, C.; Hodkinson, L.; Rieder, L. E.
10.1101/2022.09.11.507040 — genetics — Posted on 2022-09-13
2653 Evolutionary trajectories are contingent on mitonuclear interactions
Biot-Pelletier, D.; Bettinazzi, S.; Gagnon-Arsenault, I.; Dube, A. K.; Bedard, C.; Nguyen, T. H. M.; Fiumera, H.; Breton, S.; Landry, C.
10.1101/2022.09.11.507487 — evolutionary biology — Posted on 2022-09-13
2654 The Chalcidoidea bush of life - a massive radiation blurred by mutational saturation
Cruaud, A.; Rasplus, J.-Y.; Zhang, J.; Burks, R.; Delvare, G.; Fusu, L.; Gumovsky, A.; Huber, J. T.; Jansta, P.; Mitroiu, M.-D.; Noyes, J. S.; van Noort, S.; Baker, A.; Böhmova, J.; Baur, H.; Blaimer, B. B.; Brady, S. G.; Bubenikova, K.; Chartois, M.; Copeland, R. S.; Dale-Skey Papilloud, N.; Dal Molin, A.; Dominguez, C.; Gebiola, M.; Guerrieri, E.; Kresslein, R. L.; Krogmann, L.; Moriarty Lemmon, E.; Murray, E. A.; Nidelet, S.; Nieves-Aldrey, J. L.; Perry, R. K.; Peters, R. S.; Polaszek, A.; Saune, L.; Torrens, J.; Triapitsyn, S.; Tselikh, E. V.; Yoder, M.; Lemmon, A. R.; Woolley, J. B.; Her
10.1101/2022.09.11.507458 — evolutionary biology — Posted on 2022-09-13
2658 Tumor suppressor p53 deficiency increases tumor immunogenicity through promoting IL33-mediated anti-tumor immune responses
Li, Y.; Gao, D. S.; Yi, L.; Gao, F.; Sun, R.; Lu, K. K.; Xu, J.; Shoush, J.; Kykrou, Z.; Liang, M.; Lu, B.
10.1101/2022.09.11.507505 — immunology — Posted on 2022-09-13
2660 Practical scan-length considerations for mapping upper limb movements to the somatosensory/motor cortex at 7T
Rangaprakash, D.; Rowe, O. E.; Song, H.; Gutierrez-Arango, S.; Fernandez, M. F.; Israel, E. A.; Herr, H. M.; Barry, R. L.
10.1101/2022.09.11.507497 — neuroscience — Posted on 2022-09-13
2661 Subtype-specific roles of ellipsoid body ring neurons in sleep regulation in Drosophila
Yan, W.; Lin, H.; Yu, J.; Wiggin, T. D.; Wu, L.; Meng, Z.; Liu, C.; Griffith, L.
10.1101/2022.09.11.507483 — neuroscience — Posted on 2022-09-13
2662 Two gustatory receptors involved in host plant recognition of silkworm larvae
Endo, H.; Tsuneto, K.; Yamagishi, T.; Dingze, M.; Ito, K.; Nagata, S.; Sato, R.
10.1101/2022.09.12.507514 — neuroscience — Posted on 2022-09-13
2663 Roles of the 5-HT2C receptor on zebrafish sociality
Moura, L. A.; Pyterson, M. P.; Pimentel, A. F. N.; Araujo, F.; de Sousa, L. V. X. B.; Mendes, C. H. M.; Costa, B. P. D.; de Siqueira-Silva, D. H.; Lima-Maximino, M.; Maximino, C.
10.1101/2022.09.12.507567 — neuroscience — Posted on 2022-09-13
2667 Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of the mitochondrial protease LONP1
Mo, A. Y.-C.; Kincross, H.; Wang, X.; Chang, L. Y.-T.; Duns, G.; Kwan, H.; Lau, T.; Docking, T. R.; Tran, J.; Colborne, S.; Cheng, S.-W. G.; Huang, S.; Gharaee, N.; Willie, E.; Jiang, J.; Parker, J.; Bridgers, J.; Wood, D.; Klein Geltink, R.; Morin, G. B.; Karsan, A.
10.1101/2022.09.10.507366 — cancer biology — Posted on 2022-09-13
2668 Treatment with anti-HER2 chimeric antigen receptor tumor-infiltrating lymphocytes (CAR-TILs) is safe and associated with antitumor efficacy in mice and companion dogs
Forsberg, E. M.; Riise, R.; Saellstrom, S.; Karlsson, J. W.; Alsen, S.; Bucher, V.; Hemminki, A. E.; Olofsson Bagge, R.; Ny, L.; Nilsson, L. M.; Ronnberg, H.; Nilsson, J. A.
10.1101/2022.09.11.507449 — cancer biology — Posted on 2022-09-13
2669 Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resource
Nguyen, H. T.; Tang, W.; Webster, A. L. H.; Whiteaker, J. R.; Chandler, C. M.; Errazquin, R.; Sullivan, L. B.; Jonlin, E.; Hoskins, E. E.; Chen, E. Y.; Fritzke, M.; Paulovich, A. G.; Wells, S. I.; Roohollahi, K.; Dorsman, J.; Brakenhoff, R.; Garcia-Escudero, R.; Smogorzewska, A.; Wakefield, L.; Grompe, M.; Monnat, R. J.
10.1101/2022.09.11.507488 — cancer biology — Posted on 2022-09-13
2670 Phase Transitions in Lipid Bilayers by Biomimetic Photoswitches Based on Cyclocurcumin
Delova, A.; Losantos, R.; Pecourneau, J.; Bernhard, Y.; Mourer, M.; Pasc, A.; Monari, A.
10.1101/2022.09.11.507454 — biophysics — Posted on 2022-09-13
2676 Defining Cardiac Recovery at Single Cell Resolution
Amrute, J. M.; Lai, L.; Ma, P.; Koenig, A. L.; Kamimoto, K.; Bredemeyer, A.; Shankar, T. S.; Kuppe, C.; Kadyrov, F. F.; Schulte, L. J.; Stoutenburg, D.; Kopecky, B.; Navankasattusas, S.; Visker, J.; Morris, S. A.; Kramann, R.; Leuschner, F.; Mann, D. L.; Drakos, S. G.; Lavine, K. J.
10.1101/2022.09.11.507463 — genomics — Posted on 2022-09-13
2677 Tropical high-altitude insects show limited capacity to handle high temperatures
Rajpurohit, S.; Solanki, P. S.; Mayekar, H. V.; Arya, H.; Aradhya, R.; Suravajhala, P.; Loeschcke, V.
10.1101/2022.09.10.507406 — evolutionary biology — Posted on 2022-09-13
2682 Assessing the zoonotic potential of a novel bat morbillivirus
Ikegame, S.; Carmichael, J. C.; Wells, H.; Furler O'Brien, R. L.; Acklin, J. A.; Chiu, H.-P.; Oguntuyo, K. Y.; Cox, R. M.; Patel, A. R.; Kowdle, S.; Stevens, C. S.; Eckley, M.; Zhan, S.; Lim, J. K.; Veit, E. C.; Evans, M.; Hashiguchi, T.; Durigon, E. L.; Schountz, T.; Epstein, J. E.; Plemper, R. K.; Daszak, P.; Anthony, S. J.; Lee, B.
10.1101/2021.09.17.460143 — microbiology — Posted on 2022-09-13
2683 A cryptic transcription factor regulates Caulobacter adhesin development
McLaughlin, M.; Hershey, D. M.; Reyes Ruiz, L. M.; Fiebig, A.; Crosson, S.
10.1101/2022.05.23.493133 — microbiology — Posted on 2022-09-13
2684 Enhancing adoptive T cell therapy with synergistic host immune engagement promotes long-term protection against solid tumors
Adu-Berchie, K.; Brockman, J. M.; Liu, Y.; Zhang, D. K. Y.; Najibi, A. J.; Stafford, A.; Sobral, M. C.; Binenbaum, Y.; Dellacherie, M. O.; Mooney, D. J.
10.1101/2022.09.10.507437 — immunology — Posted on 2022-09-13
2691 Uncertainty revealed by delayed responses during olfactory matching
Bhowmik, R.; Pardasani, M.; Mahajan, S.; Bhattacharjee, A. S.; Konakamchi, S.; Phadnis, S.; Musthafa, T.; McGowan, E.; Srikanth, P.; Marathe, S. D.; Abraham, N. M.
10.1101/2022.09.11.507462 — neuroscience — Posted on 2022-09-13
2692 Modeling cell size regulation under complex and dynamic environments
Nieto Acuna, C. A.; Vargas-Garcia, C. A.; Singh, A.; Pedraza, J. M.
10.1101/2022.09.09.507356 — systems biology — Posted on 2022-09-13
2694 Huntingtin Over-Expression Does Not Alter Overall Survival in Murine Cancer Models
Chan, L.; Hill, A.; Lu, G.; Van Raamsdonk, J.; Gascoyne, R. D.; Hayden, M. R.; Leavitt, B. R.
10.1101/2022.09.11.507440 — cancer biology — Posted on 2022-09-13
2696 The glutathione S-transferase Gstt1 is a robust driver of survival and dissemination in metastases
Ferrer, C. M.; Boon, R.; Cho, H.; Bernasocchi, T.; Wong, L. P.; Cetinbas, M.; Haggerty, E. R.; Mitsiades, I.; Wojtkiewicz, G. R.; McLoughlin, D. E.; Rheinbay, E.; Sadreyev, R.; Juric, D.; Mostoslavsky, R.
10.1101/2022.09.10.507413 — cancer biology — Posted on 2022-09-13
2698 E-cigarette aerosol exposure of pulmonary surfactant impairs its surface tension reducing function
Graham, E.; McCaig, L.; Shui-Kei Lau, G.; Tejura, A.; Cao, A.; Zuo, Y. Y.; Veldhuizen, R.
10.1101/2022.08.16.501319 — biophysics — Posted on 2022-09-13
2703 Transcriptional profiles of functionally distinct HLADR+CD38+ CD8 T cells subsets from acute febrile dengue patients
Singh, P.; Bajpai, P.; Maheshwari, D.; Chawla, Y. M.; Gottimukkala, K.; Reddy, E. S.; Saini, K.; Nayak, K.; Gunisetty, S.; Aggarwal, C.; Jain, S.; Verma, C.; Jain, P.; Soneja, M.; Wig, N.; Murali-Krishna, K.; Chandele, A.
10.1101/2022.09.09.507387 — immunology — Posted on 2022-09-13
2704 In vivo Safety and Immunoactivity of Oncolytic Jurona Virus in Hepatocellular Carcinoma: A Comprehensive Proteogenomic Analysis
Zhang, Y.; Tesfay, M.; Ferdous, K. U.; Taylor, M.; Gabere, M. N.; Simoes, C. C.; Dumbauld, C.; Barro, O.; Graham, A.; Washam, C. L.; Alkam, D.; Gies, A.; Chamcheu, J. C.; Byrum, S. D.; Post, S. R.; Kelly, T.; Borad, M.; Cannon, M. J.; Basnakian, A.; Nagalo, B. M.
10.1101/2022.09.09.507330 — immunology — Posted on 2022-09-13
2709 Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes
Rose, N. H.; Badolo, A.; Sylla, M.; Akorli, J.; Otoo, S.; Gloria-Soria, A.; Powell, J. R.; White, B. J.; Crawford, J. E.; McBride, C. S.
10.1101/2022.09.09.507331 — evolutionary biology — Posted on 2022-09-13
2712 Body mass change over winter is consistently sex-specific across roe deer populations
Hewison, A. J. M.; Bonnot, N.; Gaillard, J.-M.; Kjellander, P.; Lemaitre, J.-F.; Morellet, N.; Pellerin, M.
10.1101/2022.09.09.507329 — ecology — Posted on 2022-09-13
2713 Effects of ancient anthropogenic clam gardens on the growth, survival, and transcriptome of Pacific littleneck clams (Leukoma staminea)
Raap, M. R.; Gurney-Smith, H. J.; Dudas, S. E.; Pearce, C. M.; Leong, J. S.; Sutherland, B. J. G.; Koop, B. F.
10.1101/2022.09.09.507365 — ecology — Posted on 2022-09-13
2717 Denoising physiological data collected during multi-band, multi-echo EPI sequences
Bottenhorn, K. L.; Salo, T.; Riedel, M. C.; Sutherland, M. T.; Robinson, J. L.; Musser, E. D.; Laird, A. R.
10.1101/2021.04.01.437293 — physiology — Posted on 2022-09-13
2718 A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius)
Brown, A. R.; Comai, K.; Mannino, D.; McCullough, H.; Meyers, H. C.; Donekal, Y.; The BIO306 Consortium, ; Graves, C. W.; Seidel, H. S.
10.1101/2021.05.19.444867 — genetics — Posted on 2022-09-13
2720 Positive effects of tree diversity on tropical forest restoration in a field-scale experiment
Veryard, R.; Wu, J.; O'Brien, M. J.; Anthony, R.; Both, S.; Burslem, D. F. R. P.; Chen, B.; Fernandez-Miranda Cagigal, E.; Godfray, H. C. J.; Godoong, E.; Liang, S.; Saner, P.; Schmid, B.; Sau Wai, Y.; Xie, J.; Reynolds, G.; Hector, A.
10.1101/2022.09.09.507141 — ecology — Posted on 2022-09-13
2721 Redox regulation of Kv7 channels through EF3 hand of calmodulin
Nunez, E.; Jones, F.; Muguruza-Montero, A.; Urrutia, J.; Aguado, A.; Malo, C.; Domene, C.; Bernardo-Seisdedos, G.; Millet, O.; Gamper, N.; Villarroel, A.
10.1101/2022.09.11.507486 — cell biology — Posted on 2022-09-13
2723 GPU-Accelerated All-atom Particle-Mesh Ewald Continuous Constant pH Molecular Dynamics in Amber
Harris, J. A.; Liu, R.; Martins de Oliveira, V.; Vazquez Montelongo, E.; Henderson, J. A.; Shen, J.
10.1101/2022.06.04.494833 — biophysics — Posted on 2022-09-13
2725 A Corollary Discharge Circuit in Human Speech
Khalilian-Gourtani, A.; Wang, R.; Chen, X.; Yu, L.; Dugan, P.; Friedman, D.; Doyle, W.; Devinsky, O.; Wang, Y.; Flinker, A.
10.1101/2022.09.12.507590 — neuroscience — Posted on 2022-09-13
2726 Selective attention reduces responses to relevant sounds in human auditory cortex
Castellanos, A. L.; De Martino, F.; Ghose, G. M.; Gulban, O. F.; Moerel, M.
10.1101/2022.09.12.507664 — neuroscience — Posted on 2022-09-13
2731 Non-necessary neural activity in the primate cortex
Tremblay, S.; Testard, C.; Inchauspe, J.; Petrides, M.
10.1101/2022.09.12.506984 — neuroscience — Posted on 2022-09-13
2733 Hourglass, a tool to mine bioimaging data, uncovers sex-disparities in the IL-6-associated T cell response in pancreatic tumors
Aliar, K.; Waterhouse, H. R.; Vyas, F.; Krebs, N.; Poulton, E.; Zhang, B.; Chan, N.; Bronsert, P.; Fischer, S. E.; Gallinger, S.; Grünwald, B. T.; Khokha, R.
10.1101/2022.09.12.507618 — cancer biology — Posted on 2022-09-13
2735 Impact of storage on starch digestibility and texture of a high-amylose wheat bread
Corrado, M.; Zafeiriou, P.; Ahn-Jarvis, J. H.; Savva, G. M.; Edwards, C. H.; Hazard, B. A.
10.1101/2022.07.04.498686 — biochemistry — Posted on 2022-09-13
2738 Discovery and characterization of LNCSOX17 as an essential regulator in human endoderm formation
Landshammer, A.; Bolondi, A.; Kretzmer, H.; Much, C.; Buschow, R.; Rose, A.; Wu, H.-J.; Mackowiak, S.; Braendl, B.; Giesselmann, P.; Tornisiello, R.; Parsi, K. M.; Huey, J.; Mielke, T.; Meierhofer, D.; Maehr, R.; Hnisz, D.; Michor, F.; Rinn, J. L.; Meissner, A.
10.1101/2022.09.12.507139 — genomics — Posted on 2022-09-13
2739 Unified establishment and epigenetic inheritance of DNA methylation through cooperative MET1 activity
Briffa, A.; Hollwey, E.; Shahzad, Z.; Moore, J. D.; Lyons, D. B.; Howard, M.; Zilberman, D.
10.1101/2022.09.12.507517 — genetics — Posted on 2022-09-13
2740 Global phylogenomic assessment of Leptoseris and Agaricia reveals substantial undescribed diversity at mesophotic depths
Gijsbers, J. C.; Englebert, N.; Prata, K. E.; Pichon, M.; Dinesen, Z.; Brunner, R.; Eyal, G.; Gonzalez-Zapata, F. L.; Kahng, S. E.; Latijnhouwers, K. R.; Muir, P.; Radice, V. Z.; Sanchez, J. A.; Vermeij, M. J.; Hoegh-Guldberg, O.; Jacobs, S. J.; Bongaerts, P.
10.1101/2022.09.12.504660 — evolutionary biology — Posted on 2022-09-13
2744 Using Watershed Characteristics for Improving Fecal Source Identification
Hart, J. J.; Jamison, M. N.; McNair, J. N.; Woznicki, S. A.; Jordan, B.; Rediske, R. R.
10.1101/2022.06.16.496426 — microbiology — Posted on 2022-09-13
2746 Immunological landscape of human lymph nodes during ex vivo measles virus infection
Acklin, J. A.; Patel, A. R.; Horiuchi, S.; Moss, A. S.; Kurland, A. P.; Thibault, P.; Degrace, E. J.; Ikegame, S.; Carmichael, J.; Imai, N.; Ueno, H.; Tweel, B.; Johnson, J. R.; Rosenberg, B. R.; Lee, B.; Lim, J. K.
10.1101/2022.09.12.507535 — immunology — Posted on 2022-09-13
2748 Microbial glutamate metabolism predicts intravenous cocaine self-administration in Diversity Outbred mice
Tran, T. D. B.; Nguyen, H.; Sodergren, E.; Center for Systems Neurogenetics of Addiction, ; Dickson, P. E.; Wright, S.; Philip, V. M.; Weinstock, G. M.; Chesler, E. A.; Zhou, Y.; Bubier, J. A.
10.1101/2022.09.11.507297 — neuroscience — Posted on 2022-09-13
2755 A new route for integron cassette dissemination among bacterial genomes
Loot, C.; Millot, G.; Richard, E.; Darracq, B.; Vit, C.; Parissi, V.; Lemoine, F.; Niault, T.; Cury, J.; Rocha, E. P.; Mazel, D.
10.1101/2022.09.11.507474 — genetics — Posted on 2022-09-13
2756 In silico labeling enables kinetic myelination assay in brightfield
Fang, J.; Bergsdorf, E. Y.; Unterreiner, V.; La Greca, A.; Dergai, O.; Claerr, I.; Luong-Nguyen, N.-H.; Galuba, I.; Moutsatsos, I.; Hatakeyama, S.; Groot-Kormelink, P.; Zeng, F.; Zhang, X.
10.1101/2022.09.11.507500 — cell biology — Posted on 2022-09-13
2757 Miniaturised structured illumination microscopy using two 3-axis MEMS micromirrors
Tinning, P. W.; Donnachie, M.; Christopher, J.; Uttamchandani, D.; Bauer, R.
10.1101/2022.09.12.507543 — cell biology — Posted on 2022-09-13
2759 The ribosome quality control factors Asc1 and Hel2 regulate the expression of HSP70 during heat shock and recovery
Boopathy, L. R. A.; Beadle, E.; Xiao, A.; Rico, A. G.-B.; Alecki, C.; Garcia de Andres, I.; Vera, M.
10.1101/2022.09.12.507689 — molecular biology — Posted on 2022-09-13
2763 Discovery of a novel monoclonal PD-L1 antibody H1A that promotes T-cell mediated tumor killing activity in renal cell carcinoma
An, Z.; Gicobi, J. K.; Harrington, S. M.; Zhang, H.; Xu, T.; Hirdler, J. B.; Lohse, C.; Leibovich, B. C.; Dong, H.; Lucien, F.
10.1101/2022.09.10.507426 — immunology — Posted on 2022-09-13
2764 Transiently heritable fates and quorum sensing drive early IFN-I response dynamics
Van Eyndhoven, L. C.; Verberne, V. P. G.; Bouten, C. V. C.; Singh, A.; Tel, J.
10.1101/2022.09.11.507479 — immunology — Posted on 2022-09-13
2767 Annotation of Spatially Resolved Single-cell Data with STELLAR
Brbic, M.; Cao, K.; Hickey, J. W.; Tan, Y.; Snyder, M.; Nolan, G. P.; Leskovec, J.
10.1101/2021.11.24.469947 — bioinformatics — Posted on 2022-09-13
2771 A Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1-mediated Trabeculation Cessation
Conlon, F.; Shi, W.; Scialdone, A. P.; Emerson, J. I.; Mei, L.; Wasson, L. K.; Davies, H. A.; Seidman, C. E.; Seidman, J. G.; Cook, J.
10.1101/2022.09.12.507607 — developmental biology — Posted on 2022-09-12
2772 Stimulation-responsive enhancers regulate inflammatory gene activation through retention and modification of H2A.Z-variant accessible nucleosomes
Sporrij, A.; Prasad, M.; Muhire, B.; Fast, E. M.; Manning, M. E.; Choudhuri, A.; Weiss, J.; Koh, M.; Yang, S.; Kingston, R. E.; Tolstorukov, M.; Clevers, H.; Zon, L. I.
10.1101/2022.09.12.507565 — developmental biology — Posted on 2022-09-13
2773 Drosophila Males Use 5'-to-3' Phased Biogenesis to Make Stellate-silencing piRNAs that Lack Homology to Maternally Deposited piRNA Guides
Venkei, Z. G.; Gainetdinov, I.; Starostik, M.; Choi, C.; Chen, P.; Balsara, C.; Whitfield, T.; Bell, G. W.; Feng, S.; Jacobsen, S. E.; Aravin, A.; Kim, J. K.; Zamore, P.; Yamashita, Y. M.
10.1101/2022.09.12.507655 — developmental biology — Posted on 2022-09-13
2774 Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition
Mattia, Z.; Banfi, F.; Massimino, L.; Volpin, M.; Bellini, E.; Brusco, S.; Merelli, I.; Barone, C.; Bruni, M.; Bossini, L.; Lamparelli, L. A.; Pintado, L.; Spinelli, S.; Mologni, L.; Colasante, G.; Ungaro, F.; Cioni, J.-M.; Azzoni, E.; Piazza, R.; Montini, E.; Broccoli, V.; Sessa, A.
10.1101/2022.09.12.507599 — developmental biology — Posted on 2022-09-13
2778 Camel urine limits proliferation and modifies cell morphology in human renal tumoral and non-tumoral cells
Iglesias Pastrana, C.; Sgobba, M. N.; Navas Gonzalez, F. J.; Delgado Bermejo, J. V.; Duarte, I. F.; Lentini, G.; Kamal Sayed Osman, T.; Guerra, L.; Ciani, E.
10.1101/2022.09.12.507088 — cell biology — Posted on 2022-09-13
2779 Identification of a novel family of benzimidazole species-selective Complex I inhibitors as potential anthelmintics
Davie, T. W.; Serrat, X.; Snider, J.; Stagljar, I.; Hirano, H.; Watanabe, N.; Osada, H.; Fraser, A. G.
10.1101/2022.09.12.507634 — molecular biology — Posted on 2022-09-13
2781 Prevalence and public health significance of Lyssavirus in bats in North region of Cameroon
Dah, I.; Namegni, R. S. P.; Mouiche, M. M. M.; Dickmu, S. J.; Nguena, R. G. N.; Conclois, I.; Florian, L.; God-Yang, L.; Feussom, J. M. K.; Wade, A.; Misse, D.; Awah-Ndukum, J.
10.1101/2022.09.12.507528 — microbiology — Posted on 2022-09-12
2782 Molecular analysis of the interactions between phages and the bacterial host Klebsiella pneumoniae
Bleriot, I.; Blasco, L.; Pacios, O.; Fernandez-Garcia, L.; Lopez, M.; Ortiz-Cartagena, C.; Barrio-Pujante, A.; Fernandez-Cuenca, F.; Pascual, A.; Martinez-Martinez, L.; Oteo-Iglesias, J.; Tomas, M.
10.1101/2022.09.12.507515 — microbiology — Posted on 2022-09-13
2784 Structural basis for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEB
Cui, Z.; Napolitano, G.; de Araujo, M. E. G.; Esposito, A.; Monfregola, J.; Huber, L.; Ballabio, A.; Hurley, J. H.
10.1101/2022.09.12.507619 — cell biology — Posted on 2022-09-12
2786 Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction
Mikhajlov, O.; Adar, R. M.; Tatulea-Codrean, M.; Mace, A.-S.; Manzi, J.; Tabarin, F.; Battistella, A.; Di Federico, F.; Joanny, J.-F.; Tran van Nhieu, G.; Bassereau, P.
10.1101/2022.09.12.507658 — cell biology — Posted on 2022-09-12
2789 Temperature and dietary energy content influence female maturation age and egg nutritional content in Atlantic salmon
Maamela, K. S.; Asheim, E. R.; Debes, P. V.; House, A. H.; Erkinaro, J.; Liljeström, P.; Primmer, C. R.; Mobley, K. B.
10.1101/2022.09.09.507230 — ecology — Posted on 2022-09-12
2791 Cold exposure induces dynamic changes in circulating triacylglycerol species, which is dependent on intracellular lipolysis: a randomized cross-over trial
Straat, M.; Jurado Fasoli, L.; Ying, Z.; Nahon, K. J.; Janssen, L.; Boon, M.; Grabner, G.; Kooijman, S.; Zimmermann, R.; Giera, M.; Rensen, P. C.; Martinez, B.
10.1101/2022.09.09.507312 — physiology — Posted on 2022-09-12
2792 Modeling Global Genomic Instability in Chronic Myeloid Leukemia (CML) using patient-derived induced pluripotent stem cells (iPSC)
Telliam, G.; Desterke, C.; Imeri, J.; Mkacher, R.; Oudrhiri, N.; Balducci, E.; Arnoux, M.; Acloque, H.; Bennaceur-Griscelli, A.; Turhan, A. G.
10.1101/2022.09.09.505857 — cancer biology — Posted on 2022-09-12
2799 Integrating gene annotation with orthology inference at scale
Kirilenko, B. M.; Munegowda, C.; Osipova, E.; Jebb, D.; Sharma, V.; Blumer, M.; Morales, A.; Ahmed, A.-W.; Kontopoulos, D.-G.; Hilgers, L.; Zoonomia Consortium, ; Hiller, M.
10.1101/2022.09.08.507143 — genomics — Posted on 2022-09-12
2804 Low human health risks of algal toxins from consuming fish caught in Lake St. Clair
Shahmohamadloo, R. S.; Bhavsar, S. P.; Ortiz Almirall, X.; Marklevitz, S. A.; Rudman, S. M.; Sibley, P. K.
10.1101/2022.09.08.507173 — ecology — Posted on 2022-09-12
2805 Mapping global land sharing-sparing patterns between human and wildlife
Zhang, C.; Wang, Y.; Pan, S.; Yang, B.; Zhan, X.; Chang, J.; Li, J.; Dai, Q.
10.1101/2022.09.09.507273 — ecology — Posted on 2022-09-12
2806 Perceptual learning improves discrimination while distorting appearance
Szpiro, S. F. A.; Burlingham, C. S.; Simoncelli, E. P.; Carrasco, M.
10.1101/2022.09.08.507104 — neuroscience — Posted on 2022-09-12
2808 Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition
Holt, A. K.; Najumudeen, A. K.; Hoskin, A. J.; Legge, D. N.; Mortensson, E. M. H.; Flanagan, D. J.; Jones, N.; Kollareddy, M.; Collard, T. J.; Timms, P.; Sansom, O. J.; Williams, A. C.; Vincent, E. E.
10.1101/2022.08.24.505115 — cancer biology — Posted on 2022-09-12
2809 Fluorescence Lifetime: Beating the IRF and interpulse window
Fazel, M.; Vallmitjana, A.; Scipioni, L.; Gratton, E.; Digman, M. A.; Presse, S.
10.1101/2022.09.08.507224 — biophysics — Posted on 2022-09-12
2810 Literature-based predictions of treatments for genetic disease pathology
Deisseroth, C. A.; Lee, W.-S.; Kim, J.-Y.; Jeong, H.-H.; Wang, J.; Zoghbi, H. Y.; Liu, Z.
10.1101/2022.09.08.506253 — bioinformatics — Posted on 2022-09-12
2811 Weakly supervised Unet: an image classifier which learns to explain itself
O'Shea, R. J.; Horst, C.; Manickavasagar, T.; Hughes, D.; Cusack, J.; Tsoka, S.; Cook, G.; Goh, V.
10.1101/2022.09.09.507144 — bioinformatics — Posted on 2022-09-12
2813 Injectable polymer-nanoparticle hydrogel for the sustained intravitreal delivery of bimatoprost
Meany, E. L.; Andaya, R.; Tang, S.; Kasse, C. M.; Fuji, R. N.; Grosskopf, A. K.; d'Aquino, A. l.; Bartoe, J. T.; Ybarra, R.; Shelton, A.; Pederson, Z.; Hu, C.; Leung, D.; Nagapudi, K.; Ubhayakar, S.; Wright, M.; Yen, C.-W.; Appel, E.
10.1101/2022.09.08.507193 — bioengineering — Posted on 2022-09-12
2817 Refining epigenetic prediction of chronological and biological age
Bernabeu, E.; McCartney, D. L.; Gadd, D. A.; Hillary, R. F.; Lu, A. T.; Murphy, L.; Wrobel, N.; Campbell, A.; Harris, S. E.; Liewald, D.; Hayward, C.; Sudlow, C.; Cox, S. R.; Evans, K. L.; Horvath, S.; McIntosh, A. M.; Robinson, M. R.; Vallejos, C.; Marioni, R. E.
10.1101/2022.09.08.507115 — genomics — Posted on 2022-09-12
2820 Determinants restricting ACE2 recognition of MERS-related coronaviruses in bats
Ma, C.; Xiong, Q.; Gu, M.; Wang, C.; Shi, L.; Liu, C.; Si, J.; Tong, F.; Liu, P.; Huang, M.; Yan, H.
10.1101/2022.09.11.507506 — microbiology — Posted on 2022-09-12
2823 SERF deletion modifies amyloid aggregation in a mouse model of Alzheimer's disease
Stroo, E.; Janssen, L.; Sin, O.; Hogewerf, W.; Koster, M. H.; Harkema, L.; Youssef, S. A.; beschorner, N.; Wolters, A. H. G.; Bakker, B.; Thathiah, A.; Foijer, F.; van de Sluis, B.; van Deursen, J.; Jucker, M.; de Bruin, A.; Nollen, E.; Becker, L.; Garrett, L.; Marschall, S.; Hoelter, S.; Wurst, W.; Fuchs, H.; Gailus-Durner, V.; Hrabe de Angelis, M.
10.1101/2021.01.05.423442 — molecular biology — Posted on 2022-09-12
2825 Microbial community dynamics during a harmful Chrysochromulina leadbeateri bloom in northern Norway
Aalto, N. J.; Schweitzer, H.; Grann-Meyer, E.; Krsmanovic, S.; Svenning, J. B.; Dalheim, L.; Petters, S.; Ingebrigsten, R.; Hulatt, C. J.; Bernstein, H. C.
10.1101/2022.06.21.496960 — microbiology — Posted on 2022-09-12
2826 Various tomato cultivars display contrasted morphological and molecular responses to a heat wave.
Bollier, N.; Micol-Ponce, R.; Dakdaki, A.; Maza, E.; Zouine, M.; Djari, A.; Bouzayen, M.; Chevalier, C.; Delmas, F.; Gonzalez, N.; Hernould, M.
10.1101/2022.09.08.507118 — plant biology — Posted on 2022-09-12
2827 Amplicon structure creates collateral therapeutic vulnerability in cancer
Bei, Y.; Brame, L.; Kirchner, M.; Fritsche, R.; Kunz, S.; Bhattacharya, A.; Koeppke, J.; Proba, J.; Wittstruck, N.; Sidorova, O.; Chamorro, R.; Dorado Garcia, H.; Brueckner, L.; Xu, R.; Giurgiu, M.; Rodriguez-fos, E.; Koche, R.; Schmitt, C.; Schulte, J.; Eggert, A.; Haase, K.; Kirwan, J.; Heeren-Hagemann, A.; Mertins, P.; Doerr, J. R.; Henssen, A.
10.1101/2022.09.08.506647 — cancer biology — Posted on 2022-09-12
2829 Robust analysis of prokaryotic pangenome gene gain and loss rates with Panstripe
Tonkin-Hill, G.; Gladstone, R. A.; Pontinen, A. K.; Arredondo-Alonso, S.; Bentley, S. D.; Corander, J.
10.1101/2022.04.23.489244 — evolutionary biology — Posted on 2022-09-12
2830 A scenario-guided strategy for the future management of biological invasions
Roura-Pascual, N.; Saul, W.-C.; Perez-Granados, C.; Rutting, L.; Peterson, G. D.; Latombe, G.; Essl, F.; Adriaens, T.; Aldridge, D. C.; Bacher, S.; Bernardo-Madrid, R.; Brotons, L.; Diaz, F.; Gallardo, B.; Genovesi, P.; Golivets, M.; Gonzalez-Moreno, P.; Hall, M.; Kutlesa, P.; Lenzner, B.; Liu, C.; Pagitz, K.; Pastor, T.; Rabitsch, W.; Robertson, P.; Roy, H. E.; Seebens, H.; Solarz, W.; Starfinger, U.; Tanner, R.; Vila, M.; Leung, B.; Garcia-Lozano, C.; Jeschke, J. M.
10.1101/2022.09.07.506838 — ecology — Posted on 2022-09-12
2833 Neighbor-specific gene expression revealed from physically interacting cells during mouse embryonic development
Kim, J.; Rothov, M. M.; Madan, E.; Rhee, S.; Weng, G.; Palma, A. M.; Liao, L.; David, E.; Amit, I.; Hajkarim, M. C.; Gutierrez-Garcia, A.; Fisher, P. B.; Brickman, J. M.; Gogna, R.; Won, K. J.
10.1101/2021.12.02.470916 — developmental biology — Posted on 2022-09-12
2837 Comparative RNA-seq analysis of resistant and susceptible banana genotypes reveals molecular mechanisms in response to Banana bunchy top virus (BBTV)
Lantican, D. V.; Nocum, J. D. L.; Manohar, A. N. C.; Mendoza, J.-V. S.; Gardoce, R. R.; Lachica, G. C.; Gueco, L. S.; Dela Cueva, F. M.
10.1101/2022.09.08.507103 — genomics — Posted on 2022-09-12
2839 High diversity and sharing of strongylid nematodes in humans and great apes co-habiting unprotected area in Cameroon
Ilik, V.; Kreisinger, J.; Modry, D.; Schwarz, E. M.; Tagg, N.; Mbohli, D.; Charmance, N. I.; Petrzelkova, K. J.; Pafco, B.
10.1101/2022.09.08.507082 — ecology — Posted on 2022-09-12
2841 Pyrfume: A Window to the World's Olfactory Data
Castro, J. B.; Gould, T. J.; Pellegrino, R.; Liang, Z.; Coleman, L. A.; Patel, F.; Wallace, D. S.; Bhatnagar, T.; Mainland, J. D.; Gerkin, R. C.
10.1101/2022.09.08.507170 — neuroscience — Posted on 2022-09-12
2844 Embryonic Vitamin D Deficiency Programs Hematopoietic Stem Cells to Induce Type 2 Diabetes
Bernal-Mizrachi, C.; Oh, J.; Riek, A. E.; Bauerle, K. T.; Dusso, A.; McNerney, K.; Barve, R.; Darwech, I.; Sprague, J.; Moynihan, C.; Zhang, R. M.; Wang, T.; Xing, X.; Li, D.; Head, R. D.; Bambouskova, M.; Mrad, M.; Collins, A.; Sands, M. S.
10.1101/2022.09.08.507174 — physiology — Posted on 2022-09-12
2847 Microbial metabolite butyrate-prodrug polymeric micelles demonstrate therapeutic efficacy in pre-clinical models of food allergy and colitis
Wang, R.; Cao, S.; Bashir, M. E. H.; Hesser, L. A.; Su, Y.; Hong, S. M. C.; Thompson, A.; Culleen, E.; Sabados, M.; Dylla, N. P.; Campbell, E.; Bao, R.; Nonnecke, E. B.; Bevins, C. L.; Wilson, D. S.; Hubbell, J. A.; Nagler, C. R.
10.1101/2022.05.01.490224 — bioengineering — Posted on 2022-09-12
2850 Spatial tuning in nociceptive processing is driven by attention
Adamczyk, W. M.; Katra, M.; Szikszay, T.; Peugh, J.; King, C.; Luedtke, K.; Coghill, R. C.
10.1101/2022.06.16.496352 — neuroscience — Posted on 2022-09-12
2858 Live visualization of endoplasmic reticulum redox potential in zebrafish embryos reveals region-specific differences
Verma, M.; Bhatt, N. R.; Chaphalkar, A.; Verma, K.; Umale, S.; Verma, S.; Sachidanandan, C.; Chakraborty, K.
10.1101/2022.02.12.480199 — biochemistry — Posted on 2022-09-12
2863 LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammation
Ma, S.; Zhou, B.; Abe, Y.; Chen, N.; Luo, C.; Li, Y.; Patel, P. R.; Zheng, A.; Patel, S. A.; Hao, Y.; Chang, J. T.; Fu, X.; Huang, W. J. M.
10.1101/2022.03.21.485192 — immunology — Posted on 2022-09-12
2864 Mice with humanized livers reveal the involvement of hepatocyte circadian clocks in rhythmic behavior and physiology
Delbes, A.-S.; Quinones, M.; Gobet, C.; Castel, J.; Denis, R. G. P.; Jeremy, B.; Weger, B. D.; Challet, E.; Charpagne, A.; Metairon, S.; Piccand, J.; Kraus, M.; Rohde, B.; Bial, J.; Wilson, E. M.; Vedin, L.-L.; Minniti, M. E.; Pedrelli, M.; Parini, P.; Gachon, F.; Luquet, S. H.
10.1101/2022.09.08.506890 — physiology — Posted on 2022-09-12
2867 Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala
Zhou, J. L.; de Guglielmo, G.; Ho, A. J.; Kallupi, M.; Li, H.-R.; Chitre, A. S.; Carrette, L. L. G.; George, O.; Palmer, A. A.; McVicker, G. P.; Telese, F.
10.1101/2022.09.08.506493 — genomics — Posted on 2022-09-12
2868 Haplotype-resolved assemblies and variant benchmark of a Chinese Quartet
Jia, P.; Dong, L.; Yang, X.; Wang, B.; Wang, T.; Lin, J.; Wang, S.; Zhao, X.; Xu, T.; Che, Y.; Dang, N.; Ren, L.; Zhang, Y.; Wang, X.; Liang, F.; Wang, Y.; Ruan, J.; The Quartet Project Team, ; Zheng, Y.; Shi, L.; Wang, J.; Ye, K.
10.1101/2022.09.08.504083 — genomics — Posted on 2022-09-12
2869 HRDex: a tool for deriving homologous recombination deficiency (HRD) scores from whole exome sequencing data
Pluta, J.; Hausler, R.; Wubbenhorst, B.; Desai, H.; Domchek, S. M.; Nathanson, K. L.; Maxwell, K. N.
10.1101/2022.09.08.506670 — genomics — Posted on 2022-09-12
2870 Sedimentary DNA can reveal past pelagic copepod population dynamics
Nakane, K.; Liu, X.; Doi, H.; Dur, G.; Kuwae, M.; Ban, S.; Tsugeki, N.
10.1101/2022.09.09.506697 — ecology — Posted on 2022-09-12
2872 Synthesizing Images of Tau Pathology from Cross-modal Neuroimaging using Deep Learning
Lee, J.; Burkett, B. J.; Min, H.-K.; Senjem, M. L.; Dicks, E.; Corriveau-Lecavalier, N.; Mester, C. T.; Wiste, H. J.; Lundt, E. S.; Murray, M. E.; Nguyen, A. T.; Reichard, R. R.; Botha, H.; Graff-Radford, J.; Barnard, L. R.; Gunter, J. L.; Schwarz, C. G.; Kantarci, K.; Knopman, D. S.; Boeve, B. F.; Lowe, V. J.; Petersen, R. C.; Jack, C. R.; Jones, D. T.
10.1101/2022.09.07.507042 — bioengineering — Posted on 2022-09-12
2874 Targeting extracellular vesicle delivery to the lungs by microgel encapsulation
Cober, N. D.; Rowe, K.; Deng, Y.; Benavente-Babace, A.; Courtman, D. W.; Godin, M.; Stewart, D. J.
10.1101/2022.09.09.507125 — bioengineering — Posted on 2022-09-12
2875 A high-quality chromosome-level genome assembly of rohu carp, Labeo rohita, and its utilization in SNP-based exploration of gene flow and sex determination
Arick, M. A.; Grover, C. E.; Hsu, C.-Y.; Magbanua, Z. V.; Pechanova, O.; Miller, E. R.; Thrash, A.; Youngblood, R. C.; Ezzell, L.; Alam, M. S.; Benzie, J. A. H.; Hamilton, M. G.; Karsi, A.; Lawrence, M. L.; Peterson, D. G.
10.1101/2022.09.08.507226 — genomics — Posted on 2022-09-12
2877 Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.
Rashmi, P.; Sigdel, T. K.; Rychkov, D.; Damm, I.; da Silva, A. A.; Vincenti, F.; Lourenco, A. L.; Craik, C. S.; Reiser, J.; Sarwal, M. M.
10.1101/2022.09.08.507168 — immunology — Posted on 2022-09-12
2879 CD4-binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals
Gristick, H. B.; Hartweger, H.; Loewe, M.; van Schooten, J.; Ramos, V.; Oliviera, T. Y.; Nishimura, Y.; Koranda, N. S.; Wall, A.; Yao, K.-H.; Poston, D.; Gazumyan, A.; Wiatr, M.; Horning, M.; Keeffe, J. R.; Hoffmann, M. A.; Yang, Z.; Abernathy, M. E.; Dam, K.-M. A.; Gao, H.; Gnanapragasam, P. N.; Kakutani, L. M.; Pavlovitch-Bedzyk, A. J.; Seaman, M. S.; Howarth, M.; McGuire, A. T.; Stamatatos, L.; Martin, M. A.; West, A. P.; Nussenzweig, M. C.; Bjorkman, P. J.
10.1101/2022.09.08.507086 — immunology — Posted on 2022-09-12
2880 A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
Garnish, S. E.; Martin, K. R.; Kauppi, M.; Jackson, V.; Ambrose, R.; Eng, V. V.; Frank, D.; Tovey Crutchfield, E. C.; Patel, K. M.; Chiou, S.; Samson, A. L.; Doerflinger, M.; Horne, C. R.; Hall, C.; Young, S. N.; Athanasopoulos, V.; Vinuesa, C. G.; Slade, C. A.; Pearson, J. S.; Ebert, G.; Silke, J.; Murphy, J. M.; Hildebrand, J.
10.1101/2022.09.08.507056 — immunology — Posted on 2022-09-12
2881 Natural killer cell-mimic nanoparticles can actively target and kill acute myeloid leukemia cells
Alizadeh Zeinabad, H.; Yeoh, W. J.; Lomora, M.; Banz, Y.; Riether, C.; Krebs, P.; Szegezdi, E.
10.1101/2022.09.09.507236 — cancer biology — Posted on 2022-09-11
2883 Multilayer Networks of Plasmid Genetic Similarity Reveal Potential Pathways of Gene Transmission
Shapiro, J. T.; Zorea, A.; Brown Kav, A.; Ontiveros, V. J.; Mizrahi, I.; Pilosof, S.
10.1101/2022.09.08.507140 — ecology — Posted on 2022-09-11
2889 G-quadruplexes rescuing protein folding
Son, A.; Huizar Cabral, V.; Litberg, T. J.; Horowitz, S.
10.1101/2022.09.09.507295 — biophysics — Posted on 2022-09-11
2891 Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles.
Tebben, K.; Yirampo, S.; Coulibaly, D.; Kone, A. K.; Laurens, M. B.; Stucke, E.; Dembele, A.; Tolo, Y.; Traore, K.; Niangaly, A.; Berry, A. A.; Kouriba, B.; Plowe, C. V.; Doumbo, O. K.; Lyke, K. E.; Takala-Harrison, S.; Thera, M. A.; Travassos, M. A.; Serre, D.
10.1101/2022.09.09.507248 — microbiology — Posted on 2022-09-11
2892 Targeting intracellular Neu1 for Coronavirus Infection Treatment
Yang, D.; Wu, Y.; Turan, I.; Keil, J.; Li, K.; Chen, M. H.; Liu, R.; Wang, L.; Sun, X.-L.; Chen, G.
10.1101/2022.09.09.507342 — microbiology — Posted on 2022-09-11
2893 Treatment with anti-inflammatory viral serpin modulates immuno-thrombotic responses and improves outcomes in SARS-CoV-2 infected mice
Zhang, L.; Li, Y. H.; Kibler, K.; Kraberger, S.; Varsani, A.; Turk, J.; Elmadbouly, N.; Aliskevich, E.; Spaccarelli, L.; Estifanos, B.; Enow, J.; Zanetti, I. R.; Saldevar, N.; Lim, E.; Browder, K.; Wilson, A.; Juan, F. A.; Pinteric, A.; Garg, A.; Gisriel, S.; Jacobs, B.; Karr, T. L.; Florsheim, E. B.; Kumar, V.; Wallen, J.; Rahman, M.; McFadden, D. G.; Hogue, B.; Lucas, A. R.
10.1101/2022.09.09.507363 — microbiology — Posted on 2022-09-11
2895 NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis
Pacl, H. T.; Chinta, K. C.; Reddy, V. P.; Nadeem, S.; Sevalkar, R. R.; Nargan, K.; Lumamba, K.; Naidoo, T.; Glasgow, J. N.; Agarwal, A.; Steyn, A. J. C.
10.1101/2022.09.11.507472 — microbiology — Posted on 2022-09-11
2897 An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options
Kang, J. Y.; Mishanina, T. V.; Bao, Y.; Chen, J.; Llewellyn, E.; Liu, J.; Darst, S. A.; Landick, R.
10.1101/2022.09.11.507475 — biochemistry — Posted on 2022-09-11
2898 Conformational Changes Regulate Metal Coordination in the Catalytic Sites of Cas9
Das, A.; Rai, J.; Roth, M. O.; Shu, Y.; Medina, M. L.; Barakat, M. R.; Li, H.
10.1101/2022.09.10.507422 — biochemistry — Posted on 2022-09-11
2899 Branch point evolution controls species-specific alternative splicing and regulates long term potentiation
Franz, A.; Weber, A. I.; Preussner, M.; Dimos, N.; Stumpf, A.; Ji, Y.; Velasquez, L. M.; Voigt, A.; Schulz, F.; Neumann, A.; Kuropka, B.; Kühn, R.; Urlaub, H.; Schmitz, D.; Wahl, M.; Heyd, F.
10.1101/2022.09.09.507289 — molecular biology — Posted on 2022-09-11
2905 Evolutionary and cellular analysis of the dark pseudokinase PSKH2
Byrne, D. P.; Shrestha, S.; Daly, L. A.; Marensi, V.; Ramakrishnan, K.; Eyers, C. E.; Kannan, N.; Eyers, P. A.
10.1101/2022.09.10.507278 — biochemistry — Posted on 2022-09-11
2908 Metaplasticity: Dark exposure boosts excitability and visual plasticity in adult human cortex
Min, S. H.; Wang, Z.; Chen, M.; Hu, R.; Gong, L.; He, Z.; Wang, X.; Hess, R. F.; Zhou, J.
10.1101/2022.09.04.506561 — neuroscience — Posted on 2022-09-11
2910 Amplicon structure creates collateral therapeutic vulnerability in cancer
Bei, Y.; Brame, L.; Kirchner, M.; Fritsche, R.; Kunz, S.; Bhattacharya, A.; Koeppke, J.; Proba, J.; Wittstruck, N.; Sidorova, O.; Chamorro, R.; Dorado Garcia, H.; Brueckner, L.; Xu, R.; Giurgiu, M.; Rodriguez-fos, E.; Koche, R.; Schmitt, C.; Schulte, J.; Eggert, A.; Haase, K.; Kirwan, J.; Heeren-Hagemann, A.; Mertins, P.; Doerr, J. R.; Henssen, A.
10.1101/2022.09.08.506647 — cancer biology — Posted on 2022-09-11
2911 ARHGEF18 participates in Endothelial Cell Mechano-sensitivity in Response to Flow
Batta, S. P. R.; Rio, M.; Lebot, C.; Baron-Menguy, C.; Le Ruz, R.; Loirand, G.; Vion, A.-C.
10.1101/2022.09.10.507283 — cell biology — Posted on 2022-09-11
2917 CAPG: Comprehensive Allopolyploid Genotyper
Kulkarni, R.; Zhang, Y.; Cannon, S. B.; Dorman, K. S.
10.1101/2022.04.21.488948 — bioinformatics — Posted on 2022-09-11
2922 Formal Recognition and Classification of Gene Transfer Agents as Viriforms
Kogay, R.; Koppenhofer, S.; Beatty, J. T.; Lang, A. S.; Kuhn, J. H.; Zhaxybayeva, O.
10.1101/2022.06.10.494566 — evolutionary biology — Posted on 2022-09-11
2924 A single cell atlas of the cycling murine ovary
Morris, M. E.; Meinsohn, M.-C.; Chauvin, M.; Saatcioglu, H. D.; Kashiwagi, A.; Sicher, N. A.; Nguyen, N.; Yuan, S.; Stavely, R. G.; Hyun, M.; Donahoe, P. K.; Sabatini, B. L.; Pepin, D.
10.1101/2022.02.08.479522 — developmental biology — Posted on 2022-09-11
2929 CTCF is a DNA-tension-dependent barrier to cohesin-mediated DNA loop extrusion
Davidson, I. F.; Barth, R.; Zaczek, M.; van der Torre, J.; Tang, W.; Nagasaka, K.; Janissen, R.; Kerssemakers, J.; Wutz, G.; Dekker, C.; Peters, J.-M.
10.1101/2022.09.08.507093 — biophysics — Posted on 2022-09-11
2930 High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform
Arter, W. E.; Qi, R.; Erkamp, N. A.; Krainer, G.; Didi, K.; Welsh, T. J.; Acker, J.; Nixon-Abell, J.; Qamar, S.; Guillen-Boixet, J.; Franzmann, T. M.; Kuster, D.; Hyman, A. A.; Borodavka, A.; St George-Hyslop, P.; Alberti, S.; Knowles, T. P.
10.1101/2020.06.04.132308 — biophysics — Posted on 2022-09-11
2931 Tethered agonist activated ADGRF1 structure reveals molecular preference for Gq signaling
Jones, D. T. D.; Dates, A. N.; Rawson, S. D.; Burruss, M. M.; Lipper, C. H.; Blacklow, S. C.
10.1101/2022.09.09.507336 — biochemistry — Posted on 2022-09-11
2934 OGT controls mammalian cell viability by regulating the proteasome/mTOR/mitochondrial axis
Li, X.; Yue, X.; Sepulveda, H.; Burt, R. A.; Scott, D. A.; Carr, S. A.; Myers, S. A.; Rao, A.
10.1101/2021.09.19.461012 — cell biology — Posted on 2022-09-11
2938 MEBOCOST: Metabolite-mediated Cell Communication Modeling by Single Cell Transcriptome
Zheng, R.; Zhang, Y.; Tsuji, T.; Gao, X.; Wagner, A.; Yosef, N.; Cheng, H.; Zhang, L.; Tseng, Y.-H.; Chen, K.
10.1101/2022.05.30.494067 — bioinformatics — Posted on 2022-09-11
2939 Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
Rodriguez, O. L.; Safonova, Y.; Silver, C. A.; Shields, K.; Gibson, W. S.; Kos, J. T.; Tieri, D.; Ke, H.; Jackson, K. J. L.; Boyd, S. D.; Smith, M.; Marasco, W.; Watson, C. T.
10.1101/2022.07.04.498729 — genomics — Posted on 2022-09-11
2941 Structure and Function of Gli123 Involved in Mycoplasma mobile Gliding
Matsuike, D.; Tahara, Y. O.; Nonaka, T.; Wu, H. N.; Hamaguchi, T.; Kudo, H.; Hayashi, Y.; Arai, M.; Miyata, M.
10.1101/2022.09.07.507039 — microbiology — Posted on 2022-09-11
2946 Ethanol Exposure Perturbs Sea Urchin Development and Disrupts Developmental Timing
Rodriguez-Sastre, N.; Shapiro, N.; Hawkins, D. Y.; Lion, A. T.; Peyreau, M.; Correa, A. E.; Dionne, K.; Bradham, C.
10.1101/2022.07.07.499183 — developmental biology — Posted on 2022-09-11
2947 NetAct: a computational platform to construct core transcription factor regulatory networks using gene activity
Su, K.; Katebi, A. R.; Kohar, V. R.; Clauss, B.; Gordin, D.; Qin, Z.; Karuturi, R. K. M.; Li, S.; Lu, M.
10.1101/2022.05.06.487898 — systems biology — Posted on 2022-09-11
2949 Specimen, Biological Structure, and Spatial Ontologies in Support of a Human Reference Atlas
Herr, B. W.; Hardi, J.; Quardokus, E. M.; Bueckle, A. D.; Caron, A. R.; Chen, L.; Wang, F.; Osumi-Sutherland, D.; Musen, M. A.; Borner, K.
10.1101/2022.09.08.507220 — bioinformatics — Posted on 2022-09-11
2951 A multiplexed plant-animal SNP array for selective breeding and species conservation applications
Montanari, S.; Deng, C.; Koot, E.; Bassil, N. V.; Zurn, J. D.; Morrison-Whittle, P.; Worthington, M. L.; Aryal, R.; Ashrafi, H.; Pradelles, J.; Wellenreuther, M.; Chagne, D.
10.1101/2022.09.07.507051 — genetics — Posted on 2022-09-11
2952 LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation
Rousse, J.; Royer, P.-J.; Evanno, G.; Lheriteau, E.; Ciron, C.; Salama, A.; Shneiker, F.; Duchi, R.; Perota, A.; Galli, C.; Cozzi, E.; Blancho, G.; Duvaux, O.; Brouard, S.; Soulillou, J.-P.; Bach, J.-M.; Vanhove, B.
10.1101/2022.09.08.507114 — immunology — Posted on 2022-09-11
2953 Lower Aβ-PET signal in white matter lesions relates to higher extracellular free water in mixed small vessel disease and Alzheimer's pathology
Ottoy, J.; Ozzoude, M.; Zukotynski, K.; Kang, M. S.; Adamo, S.; Scott, C.; Ramirez, J.; Swardfager, W.; Lam, B.; Bhan, A.; Mojiri, P.; Kiss, A.; Strother, S.; Bocti, C.; Borrie, M.; Chertkow, H.; Frayne, R.; Hsiung, R.; Laforce, R. J.; Noseworthy, M. D.; Prato, F. S.; Sahlas, D. J.; Smith, E. E.; Kuo, P. H.; Chad, J. A.; Pasternak, O.; Sossi, V.; Thiel, A.; Soucy, J.-P.; Tardif, J.-C.; Black, S. E.; Goubran, M.
10.1101/2021.12.17.473211 — neuroscience — Posted on 2022-09-11
2956 A small dynamic leaf-level model predicting photosynthesis in greenhouse tomatoes
Joubert, D.; Zhang, N.; Berman, S. R.; Kaiser, E.; Molenaar, J.; Stigter, J. D.
10.1101/2022.09.10.507401 — plant biology — Posted on 2022-09-11
2957 GLKs directly regulate carotenoid biosynthesis via interacting with GBFs in nuclear condensates in plants
Sun, T.; Zeng, S.; Wang, X.; Owens, L.; Fei, Z.; Zhao, Y.; Mazourek, M.; Giovannoni, J. J.; Li, L.
10.1101/2022.09.09.507346 — plant biology — Posted on 2022-09-11
2958 Circadian and environmental signal transduction in a natural population of Arabidopsis
Cano-Ramirez, D. L.; Nishio, H.; Muranaka, T.; de Barros Dantas, L. L.; Honjo, M. N.; Sugisaka, J.; Kudoh, H.; Dodd, A.
10.1101/2022.09.10.507414 — plant biology — Posted on 2022-09-11
2960 The baseless mutant links protein phosphatase 2A with basal cell identity in the brown alga Ectocarpus
Godfroy, O.; Zheng, M.; Yao, H.; Henschen, A.; Peters, A. F.; Scornet, D.; Colin, S.; Ronchi, P.; Hipp, K.; Nagasato, C.; Motomura, T.; Cock, J. M.; Coelho, S. M.
10.1101/2022.09.10.507423 — developmental biology — Posted on 2022-09-11
2965 A small-molecule myosin inhibitor as a targeted multi-stage antimalarial
Trivedi, D. V.; Karabina, A.; Bergnes, G.; Racca, A.; Wander, H.; Jung, S.; Mittal, N.; Huijs, T.; Ouchida, S.; Ruijgrok, P. V.; Song, D.; Wittlin, S.; Mukherjee, P.; Chakraborty, A.; Winzeler, E. A.; Burrows, J. N.; Laleu, B.; Spudich, A.; Ruppel, K.; Dechering, K.; Nag, S.; Spudich, J.
10.1101/2022.09.09.507317 — pharmacology and toxicology — Posted on 2022-09-10
2966 Evolutionary and cellular analysis of the dark pseudokinase PSKH2
Byrne, D. P.; Shrestha, S.; Daly, L. A.; Marensi, V.; Ramakrishnan, K.; Eyers, C. E.; Kannan, N.; Eyers, P. A.
10.1101/2022.09.10.507278 — biochemistry — Posted on 2022-09-10
2968 4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis
Levy, T.; Voeltzke, K.; Hauffe, L.; Alasad, K.; Snaebjornsson, M.; Marciano, R.; Scharov, K.; Planque, M.; Vriens, K.; Christen, S.; Funk, C. M.; Hassiepen, C.; Kahler, A.; Heider, B.; Picard, D.; Lim, J. K.; Bas, Z.; Bendrin, K.; Vargas-Toscano, A.; Kahlert, U.; Remke, M.; Elkabets, M.; Grunewald, T. G.; Reichert, A. S.; Fendt, S.-M. S.; Schulze, A.; Reifenberger, G.; Rotblat, B.; Leprivier, G.
10.1101/2022.09.09.507243 — cell biology — Posted on 2022-09-10
2969 Subcellular distribution of PP1 isoforms in holoenzyme complexes
Mehta, V.; Chamousset, D.; Law, J.; Ooi, S.; Campuzano, D.; Nguyen, V.; Boisvert, F.-M.; Moorhead, G. B.; Trinkle-Mulcahy, L.
10.1101/2022.09.09.507380 — cell biology — Posted on 2022-09-10
2970 Dual role of brain endothelial Gpr126 in blood-brain barrier development and ischemic stroke
Kakogiannos, N.; Scalise, A. A.; Martini, E.; Maderna, C.; Magni, S.; Gullotta, G. S.; Lampugnani, M. G.; Iannelli, F.; Beznusenko, G.; Mironov, A.; Cerutti, C.; Bentley, K.; Philippides, A.; Zanardi, F.; Bacigaluppi, M.; Martino, G.; Dejana, E.; Giannotta, M.
10.1101/2022.09.09.507316 — cell biology — Posted on 2022-09-10
2972 Stimulating microtubule growth is not the essential function of the microtubule polymerase Stu2
Carrier, J. S.; Torvi, J. R.; Jenson, E.; Jones, C.; Gangadharan, B.; Geyer, E. A.; Rice, L.; Lagesse, B.; Barnes, G.; Miller, M. P.
10.1101/2022.09.09.507218 — cell biology — Posted on 2022-09-10
2973 Acetylation of a fungal effector that translocates host PR1 facilitates virulence
Li, J.; Ma, X.; Wang, C.; Liu, S.; Yu, G.; Gao, M.; Qian, H.; Liu, M.; Luisi, B. F.; Gabriel, D. W.; Liang, W.
10.1101/2022.09.09.507325 — microbiology — Posted on 2022-09-10
2974 A membrane-associated light harvesting model is enabled by functionalized assemblies of gene-doubled TMV proteins
Dai, J.; Wilhelm, K. B.; Bischoff, A. J.; Pereira, J. H.; Dedeo, M. T.; Garcia-Almedina, D. M.; Adams, P. D.; Groves, J. T.; Francis, M. B.
10.1101/2022.09.08.507180 — bioengineering — Posted on 2022-09-10
2975 Silicon as a microfluidic material for imaging and incubation of droplets
Lobato-Dauzier, N.; Deteix, R.; Gines, G.; Baccouche, A.; Hapsianto, B. N.; Okumura, S.; Mariette, G.; Belharet, D.; Queste, S.; Jalabert, L.; Denoual, M.; Rondelez, Y.; Toshiyoshi, H.; Fujita, H.; Kim, S. H.; Fujii, T.; Genot, A. J.
10.1101/2022.09.09.507341 — biochemistry — Posted on 2022-09-10
2976 The mobility of the cap domain is essential for the substrate promiscuity of a family IV esterase from sorghum rhizosphere microbiome
Distaso, M.; Cea-Rama, I.; Coscolin, C.; Chernikova, T. N.; Tran, H.; Ferrer, M.; Sanz-Aparicio, J.; Golyshin, P. N.
10.1101/2022.09.10.507389 — biochemistry — Posted on 2022-09-10
2977 Structural insights into pore dynamics of human Pannexin isoforms
Hussain, N.; Apotikar, A.; Pidathala, S.; Mukherjee, S.; Burada, A. P.; Sikdar, S. K.; Kutti, V. R.; Penmatsa, A.
10.1101/2022.09.09.507385 — biochemistry — Posted on 2022-09-10
2978 A novel overlapping gene azyx-1 affects the translation of zyxin in C. elegans
Parmar, B.; Geens, E.; Vandeweyer, E.; Kieswetter, A.; Ludwig, C.; Temmerman, L.
10.1101/2022.09.09.507294 — genetics — Posted on 2022-09-10
2980 STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis
Zhang, C.; Zhao, S.; Deng, H.; Zhang, S.; Wang, J.; Song, X.; Yu, D.; Zhang, Y.; Deng, W.
10.1101/2022.09.09.507335 — molecular biology — Posted on 2022-09-10
2981 SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signaling pathway in the absence of VHL
Liu, C.; Li, X.; Zhu, Y.; Fen, W.; Ma, C.; Zhang, W.; Xu, Y.; Gui, L.; Aji, R.; Gao, W.-Q.; Li, L.
10.1101/2022.09.10.507394 — molecular biology — Posted on 2022-09-10
2982 The potent broadly neutralizing antibody VIR-3434 controls Hepatitis B and D Virus infection and reduces HBsAg in humanized mice
Lempp, F. A.; Volz, T.; Cameroni, E.; Benigni, F.; Zhou, J.; Rosen, L. E.; Noack, J.; Zatta, F.; Kaiser, H.; Bianchi, S.; Lombardo, G.; Jaconi, S.; Imam, H.; Soriaga, L. B.; Passini, N.; Belnap, D. M.; Schulze, A.; Luetgehetmann, M.; Telenti, A.; Cathcart, A. L.; Snell, G.; Purcell, L. A.; Hebner, C. M.; Urban, S.; Dandri, M.; Corti, D.; Schmid, M. A.
10.1101/2022.09.09.507326 — microbiology — Posted on 2022-09-10
2987 Remodelling of carbon metabolism during sulfoglycolysis in Escherichia coli
Mui, J. W.- Y.; De Souza, D. P.; Saunders, E. C.; McConville, M. J.; Williams, S.
10.1101/2022.09.09.507388 — biochemistry — Posted on 2022-09-10
2989 Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria
Shuoker, B.; Pichler, M. J.; Jin, C.; Sakanaka, H.; Wu, H.; Ana Martinez Gascuena, A.; Liu, J.; Nielsen, T. S.; Holgersson, J.; Nordberg Karlsson, E.; Juge, N.; Meier, S.; Morth, J. P.; Karlsson, N. G.; Abou Hachem, M.
10.1101/2022.09.10.507281 — biochemistry — Posted on 2022-09-10
2991 DipM controls multiple autolysins and mediates two regulatory feedback loops promoting cell constriction in C. crescentus
Izquierdo-Martinez, A.; Miguel-Ruano, V.; Hernandez-Tamayo, R.; Biboy, J.; Batuecas, M. T.; Billini, M.; Glatter, T.; Vollmer, W.; Graumann, P. L.; Hermoso, J. A.; Thanbichler, M.
10.1101/2022.09.10.507391 — microbiology — Posted on 2022-09-10
2992 An unwanted association: the threat to papaya crops by a novel potexvirus in northwest Argentina
Cabrera Mederos, D.; Debat, H. J.; Torres, C.; Portal, O.; Jaramillo Zapata, M.; Trucco, V.; Flores, C.; Ortiz, C.; Badaracco, A.; Acuna, L.; Nome, C.; Quito-Avila, D.; Bejerman, N.; Castellanos Collazo, O.; Sanchez-Rodriguez, A.; Giolitti, F.
10.1101/2022.09.09.507323 — microbiology — Posted on 2022-09-10
2993 Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue
Andelfinger, G.; Song, A.; Sindeaux, R. H. M.; Li, Y.; Affia, H.; Agnihotri, T.; Leclerc, S.; van Vliet, P. P.; Colas, M.; Guimond, J.-V.; Patey, N.; Joyal, J.-S.; Haddad, E.; Barreiro, L.
10.1101/2022.09.09.505715 — developmental biology — Posted on 2022-09-10
2997 The imprinted Mir483 is a growth suppressor and metabolic regulator functioning through IGF1
Sandovici, I.; Fernandez-Twinn, D. S.; Campbell, N.; Cooper, W. N.; Sekita, Y.; Zvetkova, I.; Ferland-McCollough, D.; Prosser, H. M.; Oyama, L. M.; Cimadomo, D.; de Queiroz, K. B.; Cheuk, C. S. K.; Smith, N. M.; Kay, R. G.; Hoelle, K.; Smith, N. H.; Geyer, S. H.; Reissig, L. F.; Weninger, W. J.; Siddle, K.; Willis, A. E.; Bushell, M.; Ozanne, S. E.; Constancia, M.
10.1101/2022.09.09.507324 — developmental biology — Posted on 2022-09-10
3001 The effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats
Singh, N.; MacNicol, E.; DiPasquale, O.; Randall, K. L.; Ndabezinhle, M.; Simmons, C.; Selvaggi, P.; Stephenson, S.; Turkheimer, F. E.; Cash, D.; Zelaya, F.; Colasanti, A.
10.1101/2022.09.10.507418 — neuroscience — Posted on 2022-09-10
3009 Probing visual sensitivity and attention in mice using reverse correlation
Lehnert, J.; Cha, K.; Yang, K.; Zheng, D. F.; Khadra, A.; Cook, E.; Krishnaswamy, A.
10.1101/2022.09.08.507101 — neuroscience — Posted on 2022-09-10
3011 Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression
Duprat, R. J.; Linn, K. A.; Satterthwaite, T. D.; Sheline, Y. I.; Liang, X.; Bagdon, G.; Flounders, M. W.; Robinson, H.; Platt, M.; Kable, J.; Long, H.; Scully, M.; Deluisi, J. A.; Thase, M.; Cristancho, M.; Reber, J.; Shinohara, R. T.; Oathes, D.
10.1101/2022.09.08.507012 — neuroscience — Posted on 2022-09-10
3012 Extensive Soma-Soma Plate-Like Contact Sites (Ephapses) Connect Suprachiasmatic Nucleus Neurons
Czeisler, M. E.; Shan, Y.; Schalek, R. L.; Berger, D. R.; Suissa-Peleg, A.; Takahashi, J. S.; Lichtman, J. W.
10.1101/2022.09.09.507192 — neuroscience — Posted on 2022-09-10
3014 The BigMac dataset: an open resource combining multi-contrast MRI and microscopy in the macaque brain
Howard, A. F.; Huszar, I. N.; Smart, A.; Cottaar, M.; Daubney, G.; Hanayik, T.; Khrapitchev, A. A.; Mars, R. B.; Mollink, J.; Scott, C.; Sibson, N. R.; Sallet, J.; Jbabdi, S.; Miller, K. L.
10.1101/2022.09.08.506363 — neuroscience — Posted on 2022-09-10
3015 Death induced by survival gene elimination (DISE) contributes to neurotoxicity in Alzheimer's disease
Paudel, B.; Jeong, S.-Y.; Martinez, C. P.; Rickman, A.; Haluck-Kangas, A.; Bartom, E. T.; Frederiksen, K.; Affaneh, A.; Kessler, J. A.; Mazzulli, J. R.; Murmann, A. E.; Rogalski, E.; Geula, C.; Ferreira, A.; Heckmann, B. L.; Green, D. R.; Sadleir, K. R.; Vassar, R.; Peter, M. E.
10.1101/2022.09.08.507157 — neuroscience — Posted on 2022-09-10
3017 Characterizing the differential distribution and targets of Sumo paralogs in the mouse brain
Suk, T. R.; Nguyen, T. T.; Fisk, Z. A.; Mitkovski, M.; Geertsma, H. M.; Parmasad, J.-L. A.; Heer, M. M.; Callaghan, S. M.; Brose, N.; Tirard, M.; Rousseaux, M. W. C.
10.1101/2022.09.09.507035 — neuroscience — Posted on 2022-09-10
3018 Examining Litter Specific Variability in Mice and its Impact on Neurodevelopmental Studies
Valiquette, V.; Guma, E.; Cupo, L.; Gallino, D.; Anastassiadis, C.; Snook, E.; Devenyi, G. A.; Chakravarty, M. M.
10.1101/2022.09.09.506402 — neuroscience — Posted on 2022-09-10
3019 Two Synaptic Convergence Motifs Define Functional Roles for Inputs to Cochlear Nucleus Bushy Cells
Spirou, G. A.; Kersting, M.; Carr, S.; Razzaq, B.; Alves-Pinto, C. Y.; Dawson, M.; Ellisman, M. H.; Manis, P. B.
10.1101/2022.09.10.507000 — neuroscience — Posted on 2022-09-10
3025 Characterizing Cone Spectral Classification by Optoretinography
Pandiyan, V. P.; Schleufer, S.; Slezak, E.; Fong, J.; Upadhyay, R.; Roorda, A.; Ng, R.; Sabesan, R.
10.1101/2022.09.07.507027 — neuroscience — Posted on 2022-09-10
3029 Activity in primate visual cortex is minimally driven by spontaneous movements
Thalluri, B. C.; Kang, I.; Lazere, A.; Quinn, K. R.; Kaliss, N.; Yates, J.; Butts, D. A.; Nienborg, H.
10.1101/2022.09.08.507006 — neuroscience — Posted on 2022-09-10
3030 Single-Cell Transcriptomic Profiling of the Zebrafish Inner Ear Reveals Molecularly Distinct Hair Cell and Supporting Cell Subtypes
Shi, T.; Beaulieu, M. O.; Saunders, L. M.; Fabian, P.; Trapnell, C.; Segil, N.; Crump, J. G.; Raible, D. W.
10.1101/2022.09.08.507120 — neuroscience — Posted on 2022-09-10
3032 Postsynaptic receptors regulate presynaptic neurotransmitter stability
Godavarthi, S. K.; Hiramoto, M.; Ignatyev, Y.; Levin, J. B.; Li, H.; Pratelli, M.; Borchardt, J.; Czajkowski, C. M.; Borodinsky, L. N.; Sweeney, L.; Cline, H. T.; Spitzer, N. C.
10.1101/2022.09.10.507343 — neuroscience — Posted on 2022-09-10
3033 Associations between methylation age and brain age in late adolescence
Sanders, F.; Baltramonaityte, V.; Donohoe, G.; Davies, N. M.; Dunn, E. C.; Cecil, C. A. M.; Walton, E.
10.1101/2022.09.08.506972 — neuroscience — Posted on 2022-09-10
3034 Histone deacetylase 3 regulates microglial function through histone deacetylation
Meleady, L.; Towris, M.; Bacarac, V.; Kim, J.; Rowland, M.; Ciernia, A. V.
10.1101/2022.09.08.507183 — neuroscience — Posted on 2022-09-10
3037 Mapping the glial transcriptome in Huntington's disease using snRNAseq: Selective disruption of glial signatures across brain regions
Boestrand, S. M. K.; Seeker, L. A.; Kazakou, N.-L.; Bestard-Cuche, N.; Jaekel, S.; Kenkhuis, B.; Henderson, N. C.; de Bot, S. T.; van Roon-Mom, W.; Priller, J.; Williams, A.
10.1101/2022.09.10.507291 — neuroscience — Posted on 2022-09-10
3038 Local and long-distance inputs dynamically regulate striatal acetylcholine during decision making
Chantranupong, L.; Beron, C. C.; Zimmer, J. A.; Wen, M. J.; Wang, W.; Sabatini, B. L.
10.1101/2022.09.09.507130 — neuroscience — Posted on 2022-09-10
3042 Unsupervised Restoration of a Complex Learned Behavior After Large-Scale Neuronal Perturbation
Wang, B.; Torok, Z.; Duffy, A.; Bell, D.; Wongso, S.; Velho, T.; Fairhall, A.; Lois, C.
10.1101/2022.09.09.507372 — neuroscience — Posted on 2022-09-10
3045 The evolution of host resistance to a virus is determined by resources, historical contingency, and time scale
Visher, E.; Mahjoub, H.; Soufi, K.; Pascual, N.; Hoang, V.; Bartlett, L. J.; Roberts, K. E.; Meaden, S.; Boots, M.
10.1101/2022.09.08.507185 — evolutionary biology — Posted on 2022-09-10
3049 Evolutionary dynamics of dengue virus in India
Jagtap, S.; Pattabiraman, C.; Sankaradoss, A.; Krishna, S.; Roy, R.
10.1101/2022.09.08.507083 — evolutionary biology — Posted on 2022-09-10
3054 Parallel genomic basis of age at maturity across spatial scales in Atlantic Salmon
Kess, T.; Lehnert, S. J.; Bentzen, P.; Duffy, S.; Messmer, A.; Dempson, J. B.; Newport, J.; Whidden, C.; Robertson, M. J.; Chaput, G.; Breau, C.; April, J.; Gillis, C.-A.; Kent, M. P.; Nugent, C.; Bradbury, I. R.
10.1101/2022.09.09.507321 — evolutionary biology — Posted on 2022-09-10
3057 Mutators drive evolution of multi-resistance to antibiotics
Gifford, D. R.; Berrios-Caro, E.; Joerres, C.; Sune, M.; Forsyth, J.; Bhattacharyya, A.; Galla, T.; Knight, C. G.
10.1101/643585 — evolutionary biology — Posted on 2022-09-10
3058 Genome-wide association studies reveal distinct genetic correlates and increased heritability of antimicrobial resistance in Vibrio cholerae under anaerobic conditions
Creasy-Marrazzo, A.; Saber, M. M.; Kamat, M.; Bailey, L. S.; Brinkley, L. M.; Cato, E. T.; Begum, Y. A.; Rashid, M. M.; Khan, A. I.; Qadri, F.; Basso, K. B.; Shapiro, B. J.; Nelson, E. J.
10.1101/2021.06.26.450051 — microbiology — Posted on 2022-09-10
3059 Commensal bacteria promote type I interferon signaling to maintain immune tolerance
Vasquez Ayala, A.; Hsu, C.-Y.; Matsuo, K.; Buzun, E.; Carrillo Terrazas, M.; Loomis, L. R.; Lu, H.-H.; Park, J.-H.; Rivaud, P.; Thomson, M.; Chu, H.
10.1101/2021.10.21.464743 — immunology — Posted on 2022-09-10
3065 Frontotemporal network engagement by human intracranial stimulation in limbic hubs
Allawala, A. B.; Bijanki, K. R.; Oswalt, D.; Mathura, R.; Adkinson, J.; Pirtle, V.; Metzger, B.; Shofty, B.; Robinson, M. E.; Anand, A.; Najera, R. A.; Gadot, R.; Harrison, M. T.; Mathew, S. J.; Goodman, W. K.; Pouratian, N.; Sheth, S.; Borton, D. A.
10.1101/2022.09.08.507155 — neuroscience — Posted on 2022-09-10
3067 Anterior hypothalamic parvalbumin neurons are glutamatergic and promote escape behavior
Laing, B. T.; Anderson, M. S.; Bonventura, J.; Jayan, A.; Sarsfield, S.; Gajendiran, A.; Michaelides, M.; Aponte, Y.
10.1101/2022.09.09.507287 — neuroscience — Posted on 2022-09-10
3068 Identification of regulatory elements in primary sensory neurons involved in neuropathic pain
Stephens, K. E.; Moore, C.; Vinson, D. A.; White, B. E.; Renfro, Z.; Zhou, W. E.; Ji, Z.; Ji, H.; Zhu, H.; Guan, Y.; Taverna, S.
10.1101/2022.09.09.507328 — neuroscience — Posted on 2022-09-10
3069 In silico, biochemical, and in vitro analysis of silvestrol binding to the DEAD box RNA helicase eIF4A reveals broad anti-pathogen potential of rocaglates across the eukaryotic tree of life
Obermann, W.; Azri, M. F. D. B.; Konopka, L.; Schmidt, N.; Magari, F.; Sherman, J.; Silva, L. M. R.; Hermosilla, C.; Ludewig, A. H.; Houhou, H.; Haberlaein, S.; Luo, M. Y.; Häcker, I.; Schetelig, M. F.; Grevelding, C. G.; Schroeder, F. C.; Lau, G.; Taubert, A.; Rodriguez, A.; Heine, A.; Yeo, T. C.; Grünweller, A.; Taroncher-Oldenburg, G.
10.1101/2022.09.09.507249 — molecular biology — Posted on 2022-09-10
3071 Molecular mechanism of substrate recognition by folate transporter SLC19A1
Dang, Y.; Zhou, D.; Du, X.; Zhao, H.; Lee, C.-H.; Yang, J.; Qin, C.; Guo, Z.; Zhang, Z.
10.1101/2022.09.09.507238 — biochemistry — Posted on 2022-09-10
3072 Tethered agonist activated ADGRF1 structure reveals molecular preference for Gq signaling
Jones, D. T. D.; Blacklow, S. C.; Dates, A. N.; Burruss, M. M.; Lipper, C. H.; Rawson, S. D.
10.1101/2022.09.09.507336 — biochemistry — Posted on 2022-09-10
3073 Comparative analysis of CRISPR off-target activity discovery tools following ex vivo editing of CD34+ hematopoietic stem and progenitor cells
Cromer, M. K.; Majeti, K. R.; Rettig, G. R.; Murugan, K.; Kurgan, G. L.; Hampton, J. P.; Vakulskas, C. A.; Behlke, M. A.; Porteus, M. H.
10.1101/2022.09.09.507306 — genomics — Posted on 2022-09-10
3075 Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design
Moussaoui, D.; Robblee, J. P.; Auguin, D.; Fisher, F.; Fagnant, P. M.; MacFarlane, J. E.; Schaletzky, J.; Wehri, E.; Mueller-Dieckmann, C.; Baum, J.; Robert-Paganin, J.; Trybus, K.; Houdusse, A.
10.1101/2022.09.09.507123 — molecular biology — Posted on 2022-09-09
3076 Transcriptome-wide characterization of piRNAs during the developmental process of European honey bee larval guts
Xu, Y.; Long, Q.; Fan, X.; Ye, Y.; Zhang, K.; Zhang, J.; Zhao, H.; Yao, Y.; Ji, T.; Lin, Z.; Fu, Z.; Chen, D.; Guo, R.
10.1101/2022.09.08.507214 — molecular biology — Posted on 2022-09-09
3078 Experimental and theoretical aspects of Golden Gate Assembly assays
Strzelecki, P.; Shpiruk, A.; Hoffmann, E.; Cech, G. M.; Kloska, A.; Hebraud, P.; Beyer, N.; Busi, F.; Grange, W.
10.1101/2022.09.09.507109 — molecular biology — Posted on 2022-09-10
3080 Staphyloxanthin production by Staphylococcus aureus promotes resistance to oxidative stress to delay diabetic wound healing
McCready-Vangi, A. R.; Campbell, A. E.; Uberoi, A.; Lovins, V. M.; White, E. K.; Morgenstern, A. R.; Gardner, S. E.; Grice, E. A.
10.1101/2022.09.09.507290 — microbiology — Posted on 2022-09-09
3082 Identification of KNX-002, a novel inhibitor of Toxoplasma motility targeting the Class XIV myosin, TgMyoA
Kelsen, A.; Kent, R. S.; Snyder, A. K.; Wehri, E.; Bishop, S. J.; Stadler, R. V.; Powell, C.; Rompikuntal, P. K.; Boulanger, M. J.; Warshaw, D. M.; Westwood, N. J.; Schaletzky, J.; Ward, G. E.
10.1101/2022.09.09.507210 — microbiology — Posted on 2022-09-09
3084 Endogenous Plasmids and Reductive Genome Evolution in Host-Associated Bacteria
XIONG, Q.; Fung, C. S.-H.; Xiao, X.; Wan, A. T.-Y.; Wang, M.; Ren, Y.; Yang, K. Y.; Cui, Y.; Liu, X.; Tsui, S. K.-W.
10.1101/2022.09.09.507235 — microbiology — Posted on 2022-09-10
3089 A novel biopolymer for mucosal adjuvant against respiratory pathogens
Hoover, A. R.; More, S.; Liu, K.; West, C. L.; Valerio, T. I.; Yu, N.; Villalva, C.; Kumar, A.; Alleruzzo, L.; Lam, S. S. K.; Hode, T.; Papin, J. F.; Chen, W. R.
10.1101/2022.09.07.506979 — bioengineering — Posted on 2022-09-09
3091 A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability
Podgorski, J. M.; Freeman, K.; Gosselin, S.; Huet, A.; Conway, J. F.; Bird, M.; Grecco, J.; Patel, S.; Jacobs-Sera, D.; Hatfull, G.; Gogarten, J. P.; Ravantti, J.; White, S. J.
10.1101/2022.09.09.507160 — biochemistry — Posted on 2022-09-09
3092 High-resolution structures map the metal import pathway in an Nramp transporter
Ray, S.; Berry, S. P.; Wilson, E. A.; Zhang, C. H.; Shekhar, M.; Singharoy, A.; Gaudet, R.
10.1101/2022.09.08.507188 — biochemistry — Posted on 2022-09-09
3093 Characterization of p38a signaling networks in cancer cells using quantitative proteomics and phosphoproteomics
Dan, Y.; Radic, N.; Gay, M.; Fernandez, A.; Arauz, G.; Vilaseca, M.; Aloy, P.; Canovas, B.; Nebreda, A. R.
10.1101/2022.09.09.507259 — biochemistry — Posted on 2022-09-09
3094 Cellular stress modulates severity of the acute respiratory distress syndrome in COVID-19
Rico-Llanos, G.; Porras, O.; Escalante, S.; Vazquez, D.; Valiente, L.; Castillo, M.; Perez-Tejeiro, J. M.; Baglietto, D.; Becerra, J.; Reguera, J. M.; Duran, I.; Csukasi, F.
10.1101/2022.09.09.507257 — cell biology — Posted on 2022-09-09
3095 Serum-dependent recruitment of the chromatin remodeler CHD8 to promoters is mediated by the ERK-ELK pathway
Reyes, J. C.; Subtil-Rodriguez, A.; Vazquez-Chavez, E.; Guerrero-Martinez, J. A.; Ceballos-Chavez, M.
10.1101/2022.09.09.507301 — molecular biology — Posted on 2022-09-09
3096 Bacterial Argonaute nucleases reveal different modes of DNA targeting in vitro and in vivo
Lisitskaya, L.; Kropocheva, E.; Agapov, A.; Prostova, M.; Panteleev, V.; Yudin, D.; Ryazansky, S.; Kuzmenko, A.; Aravin, A.; Esyunina, D.; Kulbachiskiy, A.
10.1101/2022.09.09.507302 — molecular biology — Posted on 2022-09-09
3098 Human commensal Candida albicans strains demonstrate substantial within-host diversity and retained pathogenic potential
Anderson, F. M.; Visser, N.; Amses, K.; Hodgins-Davis, A.; Weber, A. M.; Metzner, K. M.; McFadden, M. J.; Mills, R. E.; O'Meara, M. J.; James, T. Y.; OMeara, T. R.
10.1101/2022.09.09.507247 — microbiology — Posted on 2022-09-09
3101 Protein secretion zones within the Gram-positive cell wall
Strach, M.; Koch, F.; Fiedler, S.; Liebeton, K.; Graumann, P. L.
10.1101/2022.09.09.507258 — microbiology — Posted on 2022-09-09
3102 Genome analysis of Parmales, a sister group of diatoms, reveals the evolutionary specialization of diatoms from phago-mixotrophs to photoautotrophs
Ban, H.; Sato, S.; Yoshikawa, S.; Yamada, K.; Nakamura, Y.; Ichinomiya, M.; Sato, N.; Blanc-Mathieu, R.; Endo, H.; Kuwata, A.; Ogata, H.
10.1101/2022.09.09.507052 — microbiology — Posted on 2022-09-09
3103 Use of the particle agglutination/particle agglutination-inhibition test for antigenic analysis of SARS-CoV-2
Kobayashi, J.; Matsuyama, S.; Shirakura, M.; Arita, T.; Suzuki, Y.; Asanuma, H.; Watanabe, S.; Hasegawa, H.; Nakamura, K.
10.1101/2022.09.08.507221 — microbiology — Posted on 2022-09-09
3107 Probing Local Force Propagation in Tensed Fibrous Gels
Goren, S.; Levin, M.; Brand, G.; Lesman, A.; Sorkin, R.
10.1101/2022.09.07.506942 — biophysics — Posted on 2022-09-09
3112 Aerosolized Desert Dusts Collected Near a Drying Lake and Pulmonary Inflammation in Mice: Implications for Environmental Exposures and Asthma
Biddle, T. A.; Yisrael, K.; Drover, R.; Li, Q.; Maltz, M. R.; Topacio, T. M.; Yu, J.; Del Castillo, D.; Gonzalez, D.; Freund, H. M.; Swenson, M. P.; Shapiro, M. L.; Botthoff, J. K.; Aronson, E. L.; Cocker, D. R.; Lo, D. D.
10.1101/2022.09.07.506987 — pharmacology and toxicology — Posted on 2022-09-09
3116 Genetic and physiological insights into the diazotrophic activity of a non-cyanobacterial marine diazotroph
Joublin-Delavat, A.; Touahri, K.; Cretin, P.; Morot, A.; Rodrigues, S.; Jesus, B.; Trigodet, F.; Delavat, F.
10.1101/2022.07.13.499682 — microbiology — Posted on 2022-09-09
3117 Amount of Pannexin 1 in smooth muscle cells regulates sympathetic nerve induced vasoconstriction
Dunaway, L. S.; Billaud, M.; Macal, E.; Good, M. E.; Medina, C.; Lorenz, U.; Ravichandran, K.; Koval, M.; Isakson, B. E.
10.1101/2022.09.07.506995 — physiology — Posted on 2022-09-09
3120 Drosophila Atlastin regulates synaptic vesicle mobilization independent of Bone Morphogenetic Protein signaling
Bertin, F.; Jara-Wilde, J.; Auer, B.; Köhler-Solis, A.; Gonzalez-Silva, C.; Thomas, U.; Sierralta, J.
10.1101/2022.09.09.507308 — cell biology — Posted on 2022-09-09
3121 Apelin Stimulation of the Perivascular MuSC Niche Enhances Endogenous Repair in Muscular Dystrophy
Le Moal, E.; Liu, Y.; Collerette-Tremblay, J.; Dumontier, S.; Boutin, J.; Dort, J.; Orfi, Z.; Michaud, J.; Giguere, H.; Desroches, A.; Vezina, F.; Bedard, S.; Balg, F.; Sarret, P.; Scott, M. S.; Feige, J. N.; Denault, J.-B.; Dumont, N. A.; Marsault, E.; Auger-Messier, M.; Bentzinger, C. F.
10.1101/2022.09.09.507274 — cell biology — Posted on 2022-09-09
3123 Rapid emergence of extensively drug-resistant Shigella sonnei in France
Lefevre, S.; Njamkepo, E.; Feldman, S.; Ruckly, C.; Carle, I.; Lejay-Collin, M.; Fabre, L.; Yassine, I.; Frezal, L.; Pardos de la Gandara, M.; Fontanet, A.; Weill, F.-X.
10.1101/2022.09.07.506808 — microbiology — Posted on 2022-09-09
3125 Single-cell transcriptomics of resected human traumatic brain injury tissues reveals acute activation of endogenous retroviruses in oligodendrocytes
Garza, R.; Sharma, Y.; Atacho, D.; Hamdeh, S. A.; Jonsson, M. E.; Ingelsson, M.; Jern, P.; Hammell, M. G.; Englund, E.; Jakobsson, J.; Marklund, N.
10.1101/2022.09.07.506982 — neuroscience — Posted on 2022-09-09
3127 Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators
Mallick, S.; Chakrabarti, J.; Eschbacher, J.; Moraitis, A. G.; Greenstein, A. E.; Churko, J.; Pond, K. W.; Livolsi, A.; Thorne, C. A.; Little, A. S.; Yuen, K. C.; Zavros, Y.
10.1101/2022.09.07.506977 — physiology — Posted on 2022-09-09
3130 CTCF is a DNA-tension-dependent barrier to cohesin-mediated DNA loop extrusion
Davidson, I. F.; Barth, R.; Zaczek, M.; van der Torre, J.; Tang, W.; Nagasaka, K.; Janissen, R.; Kerssemakers, J.; Wutz, G.; Dekker, C.; Peters, J.-M.
10.1101/2022.09.08.507093 — biophysics — Posted on 2022-09-09
3133 p57Kip2 acts as a transcriptional corepressor to regulate intestinal stem cell fate and proliferation
Creff, J.; Nowosad, A.; Prel, A.; Pizzocaro, A.; Aguirrebengoa, M.; Duquesnes, N.; Callot, C.; Jungas, T.; Dozier, C.; Besson, A.
10.1101/2022.09.09.507138 — cell biology — Posted on 2022-09-09
3134 Open spaced ridged hydrogel scaffolds containing TiSAMP surface chemistry promotes regeneration and recovery following spinal cord injury.
Siddiqui, A. M.; Thiele, F.; Stewart, R. N.; Rangnick, S.; Weiss, G. J.; Chen, B. K.; Silvernail, J. L.; Strickland, T.; Nesbitt, J. J.; Lim, K.; Schwarzbauer, J. E.; Schwartz, J.; Yaszemski, M. J.; Windebank, A. J.; Madigan, N. N.
10.1101/2022.09.07.506969 — neuroscience — Posted on 2022-09-09
3137 DELLA proteins regulate spore germination and reproductive development in Physcomitrium patens.
Phokas, A.; Meyberg, R.; Briones-Moreno, A.; Hernandez-Garcia, J.; Wadsworth, P. T.; Vesty, E. F.; Blazquez, M. A.; Rensing, S. A.; Coates, J. C.
10.1101/2022.09.07.506957 — plant biology — Posted on 2022-09-09
3138 Distinct selection signatures during domestication and improvement in crops: a tale of two genes in mungbean
Lin, Y.-P.; Chen, H.-W.; Yeh, P.-M.; Lin, J.; Anand, S.; Li, J.; Noble, T.; Nair, R. M.; Schafleitner, R.; Samsonova, M.; Bishop-von-Wettberg, E.; Nuzhdin, S.; Ting, C.-T.; Lawn, R.; Lee, C.-R.
10.1101/2022.09.08.506689 — plant biology — Posted on 2022-09-09
3140 Various tomato cultivars display contrasted morphological and molecular responses to a heat wave.
Bollier, N.; Micol-Ponce, R.; Dakdaki, A.; Maza, E.; Zouine, M.; Djari, A.; Bouzayen, M.; Chevalier, C.; Delmas, F.; Gonzalez, N.; Hernould, M.
10.1101/2022.09.08.507118 — plant biology — Posted on 2022-09-09
3142 A Plastidial Glycolytic-Gluconeogenic Switch of Mitochondrial Origin Enables Diatom Adaptations to High Latitudes
Dorrell, R. G.; Liang, Y.; Gueguen, N.; Nonoyama, T.; Zhang, Y.; Croteau, D.; Penot, M.; Adiba, S.; Bailleul, B.; Gros, V.; Karlusich, J. J. P.; Zweig, N.; Fernie, A. R.; Jouhet, J.; Marechal, E.; Bowler, C.
10.1101/2022.09.08.507166 — plant biology — Posted on 2022-09-09
3145 Low Molecular Weight Hyaluronan Inhibits Lung Epithelial Ion Channels by Activating Calcium-Sensing Receptor
Lazrak, A.; Song, W.; Yu, Z.; Zhang, S.; Nellore, A.; Hoopes, C. W.; Woodworth, B. A.; Matalon, S.
10.1101/2022.09.07.506946 — physiology — Posted on 2022-09-09
3146 Preclinical shortwave infrared tumor screening and resection via pHLIP ICG under ambient lighting conditions
Mc Larney, B. E.; Kim, M.; Roberts, S.; Skubal, M.; Hsu, H.-T.; Ogirala, A.; PILLARSETTY, N.; Heller, D. A.; Lewis, J. S.; Grimm, J.
10.1101/2022.09.07.506973 — cancer biology — Posted on 2022-09-09
3150 Exploring high-quality microbial genomes by assembly of linked-reads with high barcode specificity using deep learning
Zhang, Z.; Wang, H.; Yang, C.; Yufen, H.; Yue, Z.; Chen, Y.; Han, L.; Lu, A.; Fang, X.; Zhang, L.
10.1101/2022.09.07.506963 — genomics — Posted on 2022-09-09
3151 Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes
Newman, J. R. B.; Long, S. A.; Speake, C.; Greenbaum, C. J.; Cerosaletti, K.; Rich, S. S.; Onengut-Gumuscu, S.; McIntyre, L.; Concannon, P.
10.1101/2022.09.07.506965 — genetics — Posted on 2022-09-09
3155 Maternal provisioning of an obligate symbiont
Carrier, T. J.; Schmittmann, L.; Jung, S.; Pita, L.; Hentschel, U.
10.1101/2022.09.07.506999 — evolutionary biology — Posted on 2022-09-09
3156 Evolutionary rates in human amyloid proteins reveal their intrinsic metastability
Zea, D.; Mac Donagh, J.; Benitez, G.; Donadio, C. E. G.; Marchetti, J.; Palopoli, N.; Fornasari, M. S.; Parisi, G.
10.1101/2022.09.07.506994 — evolutionary biology — Posted on 2022-09-09
3157 Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/Omicron variants following an inactivated whole-virus vaccine
Lu, C.; Zhang, Y.; Liu, X.; Hou, F.; Cai, R.; Yu, Z.; Liu, F.; Yang, G.; Ding, J.; Xu, J.; Hua, X.; Pan, X.; Liu, L.; Lin, K.; Wang, Z.; Li, X.; Lu, J.; Zhang, Q.; Li, Y.; Hu, C.; Fan, H.; Liu, X.; Wang, H.; Jia, R.; Xu, F.; Wang, X.; Huang, H.; Zhao, R.; Li, J.; Cheng, H.; Jia, W.; Yang, X.
10.1101/2022.09.06.506714 — molecular biology — Posted on 2022-09-09
3158 The topological shape of gene expression across the evolution of flowering plants
Palande, S.; Kaste, J. A. M.; Roberts, M. D.; Segura Aba, K.; Claucherty, C.; Dacon, J.; Doko, R.; Jayakody, T. B.; Jeffery, H. R.; Kelly, N.; Manousidaki, A.; Parks, H. M.; Roggenkamp, E. M.; Schumacher, A. M.; Yang, J.; Percival, S.; Pardo, J.; Husbands, A. Y.; Krishnan, A.; Montgomery, B. L.; Munch, E.; Thompson, A. M.; Rougon-Cardoso, A.; Chitwood, D. H.; VanBuren, R.
10.1101/2022.09.07.506951 — plant biology — Posted on 2022-09-09
3159 lincRNA RP24-315D19.10 promotes endometrialdecidualization via upregulation of hnRNPA2B1
Tan, L.; Gao, R.; Chen, X.; Geng, Y.; Yin, X.; Chuan, P.; Mu, X.; Su, Y.; Zhang, Y.; Li, F.; He, J.
10.1101/2022.09.07.506883 — molecular biology — Posted on 2022-09-09
3160 Leaf-level metabolic changes in response to drought affect daytime CO2 emission and isoprenoid synthesis
Ladd, S. N.; Daber, L. E.; Bamberger, I.; Kuebert, A.; Kreuzwieser, J.; Purser, G.; Ingrisch, J.; Deleeuw, J.; van Haren, J.; Meredith, L.; Werner, C.
10.1101/2022.04.29.490001 — plant biology — Posted on 2022-09-09
3162 Contact Stiffness Governs Mechanoresponses of Living Cells to Extracellular Microenvironment
Zhao, P.; Zheng, Y.; Zhang, Z.-Y.; Jiang, M.-W.; Jiang, Y.-X.; Du, J.; Cao, Y.-P.
10.1101/2022.09.07.506641 — biophysics — Posted on 2022-09-09
3163 Single-cell analysis of bovine muscle-derived cell types for cultured meat production
Messmer, T.; Dohmen, R. G.; Schaeken, L.; Melzener, L.; Hueber, R.; Godec, M.; Post, M. J.; Flack, J. E.
10.1101/2022.09.02.506369 — cell biology — Posted on 2022-09-09
3165 CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system.
Pernice, S.; Sirovich, R.; Grassi, E.; Viviani, M.; Ferri, M.; Sassi, F.; Alessandri, L.; Tortarolo, D.; Calogero, R. A.; Trusolino, L.; Bertotti, A.; Beccuti, M.; Olivero, M.; Cordero, F.
10.1101/2022.08.08.503120 — bioinformatics — Posted on 2022-09-09
3167 Evolution of predictive memory in the hippocampus
Miller, A. M. P.; Jacob, A. D.; Ramsaran, A. I.; De Snoo, M. L.; Josselyn, S. A.; Frankland, P. W.
10.1101/2022.09.08.507204 — neuroscience — Posted on 2022-09-09
3169 Dysregulation of The Chromatin Environment Leads to Differential Alternative Splicing as A Mechanism Of Disease In a Human Model of Autism Spectrum Disorders
Leung, C. S.; Rosenzweig, S.; Yoon, B.; Marinelli, N. A.; Hollingsworth, E. W.; Maguire, A. M.; Cowen, M. M.; Schmidt, M.; Imitola, J.; Uzun, E. D. G.; Lizarraga, S. B.
10.1101/2022.09.08.507162 — neuroscience — Posted on 2022-09-09
3171 The functional impact of rare variation across the regulatory cascade
Li, T.; Ferraro, N.; Strober, B. J.; Aguet, F.; Kasela, S.; Arvanitis, M.; Ni, B.; van de Wiel, L.; Hershberg, E.; Ardlie, K.; Arking, D. E.; Beer, R. L.; Brody, J.; Blackwell, T. W.; Clish, C.; Gabriel, S.; Gerszten, R.; Guo, X.; Gupta, N.; Johnson, W. C.; Lappalainen, T.; Lin, H. J.; Liu, Y.; Nickerson, D. A.; Papanicolaou, G.; Pritchard, J. K.; Qasba, P.; Shojaie, A.; Smith, J.; Sotoodehnia, N.; Taylor, K. D.; Tracy, R. P.; Van den Berg, D.; Wheeler, M.; Rich, S. S.; Rotter, J. I.; Battle, A. J.; Montgomery, S. B.
10.1101/2022.09.07.507008 — genomics — Posted on 2022-09-09
3172 The Neuroscience Multi-Omic Archive: A BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain
Ament, S. A.; Adkins, R. S.; Carter, R.; Chrysostomou, E.; Colantuoni, C.; Crabtree, J.; Creasy, H. H.; Degatano, K.; Kiernan, E.; Felix, V.; Gandt, P.; Garden, G. A.; Giglio, M.; Herb, B. R.; Khajouei, F.; Nickel, L.; McCracken, C.; McDaniel, K.; Nadendla, S.; Olley, D.; Orvis, J.; Receveur, J.; Schor, M.; Tickle, T. L.; Way, J.; Hertzano, R.; Mahurkar, A. A.; White, O. R.
10.1101/2022.09.08.505285 — genomics — Posted on 2022-09-09
3174 The Nanog epigenetic remodeling complex was essential to vertebrate mesoderm evolution
Simpson, L.; Crowley, D.; Forey, T.; Acosta, H.; Ferjentsik, Z.; Chatfield, J.; Payne, A.; Simpson, B.; Redwood, C.; Dixon, J.; Holmes, N.; Sang, F.; Alberio, R.; Loose, M.; Johnson, A. D.
10.1101/2022.09.08.507069 — developmental biology — Posted on 2022-09-09
3176 Identification of the Metaphyseal Skeletal Stem Cell
Yang, G.; He, Q.; Guo, X.; Li, R.-Y.; Lin, J.; Tao, W.; Liu, W.; Lin, H.; Tang, M.; Xing, S.; Qi, Y.; Peng, Y.; Dong, L.; Han, J.-D. J.; Zhou, B.; Teng, Y.; Yang, X.
10.1101/2022.09.08.506930 — developmental biology — Posted on 2022-09-09
3178 Ectodysplasin signaling via Xedar is required for mammary gland morphogenesis
Wark, A. R.; Tomizawa, R.; Aldea, D.; Kokalari, B.; Warder, B.; Kamberov, Y. G.
10.1101/2022.09.08.507158 — developmental biology — Posted on 2022-09-09
3179 Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics
Thaler, R.; Yoshizaki, K.; Nguyen, T.; Fukumoto, S.; DenBesten, p.; Bikle, D. D.; Oda, Y.
10.1101/2022.09.08.507153 — developmental biology — Posted on 2022-09-09
3186 Structure and Function of Gli123 Involved in Mycoplasma mobile Gliding
Matsuike, D.; Tahara, Y. O.; Nonaka, T.; Hamaguchi, T.; Kudo, H.; Hayashi, Y.; Arai, M.; Miyata, M.
10.1101/2022.09.07.507039 — microbiology — Posted on 2022-09-09
3189 Tissue confinement regulates cell growth and size in epithelia
Devany, J.; Falk, M. J.; Holt, L. J.; Murugan, A.; Gardel, M.
10.1101/2022.07.04.498508 — biophysics — Posted on 2022-09-08
3190 RTX-KG2: a system for building a semantically standardized knowledge graph for translational biomedicine
Wood, E. C.; Glen, A. K.; Kvarfordt, L. G.; Womack, F.; Acevedo, L.; Yoon, T. S.; Ma, C.; Flores, V.; Sinha, M.; Chodpathumwan, Y.; Termehchy, A.; Roach, J. C.; Mendoza, L.; Hoffman, A. S.; Deutsch, E. W.; Koslicki, D.; Ramsey, S. A.
10.1101/2021.10.17.464747 — bioinformatics — Posted on 2022-09-08
3193 A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
Essletzbichler, P.; Sedlyarov, V.; Frommelt, F.; Soulat, D.; Heinz, L. X.; Stefanovic, A.; Neumayer, B.; Superti-Furga, G.
10.1101/2022.09.08.507072 — genomics — Posted on 2022-09-08
3196 A novel fluorobenzothiazole RBx 10080758 as a dual inhibitor against bacterial GyraseB (GyrB) and Topoisomerase IV (parE) of Gram-positive pathogens causing skin and respiratory infections
Barman, T.; Kumar, M.; Chaira, T.; Singhal, S.; Mathur, T.; Kalia, V.; Gangadharan, R.; Rao, M.; Pandya, M.; Bhateja, P.; Sood, R.; Upadhyay, D.; Varughese, S.; Yadav, A.; Sharma, L.; Kumar, N.; Sattigeri, J.; Bhatnagar, P. K.; Raj, V. S.
10.1101/2022.09.08.507076 — microbiology — Posted on 2022-09-08
3197 Genomic and ecologic characteristics of the airway microbial-mucosal complex
Cuthbertson, L.; Lober, U.; Ish-Horowicz, J. S.; McBrien, C. N.; Churchward, C.; Parker, J. C.; Olanipekun, M. T.; Burke, C.; O'Carroll, O.; Faul, J.; Davies, G. A.; Lewis, K. E.; Hopkin, J. M.; Creaser-Thomas, J.; Ghosal, R.; Chung, K. F.; Willis-Owen, S. A. G.; Piatek, S.; Bartolomaeus, T.; Birkner, T.; Dwyer, S.; Kumar, N.; Turek, E. M.; Musk, W. A.; Hui, J.; Hunter, M.; James, A.; Dumas, M.-E.; Fillipi, S.; Cox, M. J.; Lawley, T. D.; Forslund, S. K.; Moffatt, M. F.; Cookson, W. O. C.
10.1101/2022.09.08.507073 — microbiology — Posted on 2022-09-08
3200 Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis
Nakajima-Takagi, Y.; Oshima, M.; Takano, J.; Koide, S.; Itokawa, N.; Uemura, S.; Yamashita, M.; Andoh, S.; Aoyama, K.; Isshiki, Y.; Shinoda, D.; Saraya, A.; Arai, F.; Yamaguchi, K.; Furukawa, Y.; Koseki, H.; Ikawa, T.; Iwama, A.
10.1101/2022.09.07.507016 — immunology — Posted on 2022-09-08
3202 Enhanced intrathecal drug dispersion achieved by high volume injection and natural micromixing
Ayansiji, A. O.; Gehrke, D. S.; Baralle, B.; Nozain, A.; Meenesh, S. R.; Linninger, A. A.
10.1101/2022.03.22.485353 — bioengineering — Posted on 2022-09-08
3203 Truncated RNA-binding protein production by DUX4-induced systemic inhibition of nonsense-mediated RNA decay
Campbell, A. E.; Dyle, M. C.; Calviello, L.; Matheny, T.; Sudheendran, K.; Cortazar, M. A.; Forman, T.; Fu, R.; Gillen, A. E.; Caruthers, M. H.; Floor, S. N.; Jagannathan, S.
10.1101/2021.06.28.450189 — genomics — Posted on 2022-09-08
3205 Diversity, composition, altitude, and seasonality of high-altitude windborne migrating mosquitoes in the Sahel: Implications for disease transmission
Yaro, A. S.; Linton, Y.-M.; Diallo, M.; Sanogo, Z. L.; Samake, D.; Ousman, Y.; Kouam, C.; Krajacich, B. J.; Faiman, R.; Bamou, R.; Woo, J.; Chapman, J.; Reynolds, D. R.; Lehmann, T.
10.1101/2022.08.19.504620 — ecology — Posted on 2022-09-08
3206 Cytomotive actins and tubulins share a polymerisation switch mechanism conferring robust dynamics
Wagstaff, J. M.; Planelles-Herrero, V. J.; Sharov, G.; Alnami, A.; Kozielski, F. G.; Derivery, E.; Löwe, J.
10.1101/2022.09.08.507146 — molecular biology — Posted on 2022-09-08
3208 Potentiation of Adipogenesis by Reactive Oxygen Species is a Unifying Mechanism in the Pro-adipogenic Properties of Bisphenol A and its New Structural Analogues.
Singh, R. D.; Wager, J. L.; Scheidl, T. B.; Connors, L. T.; Easson, S.; Callaghan, M. A.; Alatorre-hinojosa, S.; Swift, L. H.; Colarusso, P.; Jadli, A.; SHUTT, T.; Patel, V.; Thompson, J.
10.1101/2022.09.08.507176 — molecular biology — Posted on 2022-09-08
3209 A widespread family of phage-inducible chromosomal islands only steals bacteriophage tails to spread in nature
Alqurainy, N.; Miguel-Romero, L.; Moura de Sousa, J.; Chen, J.; Rocha, E. P. C.; Fillol-Salom, A.; Penades, J. R.
10.1101/2022.09.08.507074 — microbiology — Posted on 2022-09-08
3210 Camellia sinensis solvent extract confers trophocidal and cysticidal effects against Acanthamoeba castellanii
Fakae, L. B.; Harun, M. S. R.; Ting, D. S. J.; Dua, H. S.; Cave, G. W. V.; Zhu, X.-Q.; Stevenson, C. W.; Elsheikha, H. M.
10.1101/2022.09.08.507025 — microbiology — Posted on 2022-09-08
3213 HPV E6 upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer
Khalil, M. I.; Yang, C.; Vu, L.; Chadha, S.; Welbon, C.; James, C. D.; Morgan, I. M.; Spanos, W. C.; Pyeon, D.
10.1101/2022.09.07.507063 — microbiology — Posted on 2022-09-08
3215 Immunometabolic profiling of in vitro and ex vivo Leishmania-infected macrophages (LIMs) reveals unique polarization and bioenergetic signatures
Zhang, S.; Lecoeur, H.; Varet, H.; Legendre, R.; Mahtal, N.; Proux, C.; Aulner, N.; Short, S.; Grandjean, C.; Bousso, P.; Prina, E.; Spaeth, G. F.
10.1101/2022.09.08.507100 — immunology — Posted on 2022-09-08
3216 Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model.
Morrone Parfitt, G.; Coccia, E.; Goldman, C.; Whitney, K.; Reyes, R.; Sarrafha, L.; Nam, K. H.; Sohail, S.; Jones, D.; crary, J. F.; Ordureau, A.; Blanchard, J.; Ahfeldt, T. D.
10.1101/2022.08.26.505472 — neuroscience — Posted on 2022-09-08
3220 Rapid, DNA-induced subunit exchange by DNA gyrase
Germe, T.; Bush, N. G.; Baskerville, V.; Saman, D.; Benesch, J. L.; Maxwell, A.
10.1101/2022.09.08.507137 — biochemistry — Posted on 2022-09-08
3221 A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation
Bahar, M. W.; Nasta, V.; Fox, H.; Sherry, L.; Grehan, K.; Porta, C.; Macadam, A. J.; Stonehouse, N. J.; Rowlands, D. J.; Fry, E. E.; Stuart, D. I.
10.1101/2022.09.08.507136 — biochemistry — Posted on 2022-09-08
3223 Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel Achilles heel for therapeutic intervention
Krimmer, S. G.; Bertoletti, N.; Suzuki, Y.; Katic, L.; Mohanty, J.; Shu, S.; Lee, S.; Lax, I.; Mi, W.; Schlessinger, J.
10.1101/2022.09.08.506998 — biochemistry — Posted on 2022-09-08
3224 Overcoming Attenuation Bias in Regressions using Polygenic Indices: A Comparison of Approaches
van Kippersluis, H.; Biroli, P.; Galama, T. J.; von Hinke, S.; Meddens, S. F. W.; Muslimova, D.; Pereira, R.; Slob, E. A. W.; de Vlaming, R.; Rietveld, C. A.
10.1101/2021.04.09.439157 — genetics — Posted on 2022-09-08
3228 Oncogenic YAP mediates changes in chromatin accessibility and activity that drive cell cycle gene expression and cell migration
Fetiva, M. C.; Liss, F.; Gertzmann, D.; Thomas, J.; Gantert, B.; Vogl, M.; Sira, N.; Weinstock, G.; Kneitz, S.; Ade, C. P.; Gaubatz, S.
10.1101/2022.09.08.507127 — molecular biology — Posted on 2022-09-08
3231 Structure and Function of Gli123 Involved in Mycoplasma mobile Gliding
Matsuike, D.; Tahara, Y. O.; Nonaka, T.; Hamaguchi, T.; Kudo, H.; Hayashi, Y.; Arai, M.; Miyata, M.
10.1101/2022.09.07.507039 — microbiology — Posted on 2022-09-08
3233 Small RNAs activate Salmonella pathogenicity island 1 by modulating mRNA stability through the hilD mRNA 3' UTR
Abdulla, S. Z.; Kim, K.; Azam, M. S.; Golubeva, Y. A.; Cakar, F.; Slauch, J. M.; Vanderpool, C. K.
10.1101/2022.09.07.507058 — microbiology — Posted on 2022-09-08
3234 Postpartum estrogen withdrawal induces deficits in affective behaviors and increases ΔFosB in D1 and D2 neurons in the nucleus accumbens core in mice
Foster, W.; Beach, K. F.; Carson, P. F.; Harris, K. C.; Alonso, B. L.; Costa, L. T.; Simamora, R. C.; Corbin, J. E.; Hoag, K. F.; Mercado, S. I.; Bernhard, A. G.; Leung, C. H.; Nestler, E. J.; Been, L. E.
10.1101/2022.09.08.505352 — neuroscience — Posted on 2022-09-08
3235 Cortical Circuit Mechanisms of Multimodal Temporal Pattern Discrimination
Post, S.; Mol, W.; Abu-Wishah, O.; Ali, S.; Rahmatullah, N.; Goel, A.
10.1101/2022.08.31.506133 — neuroscience — Posted on 2022-09-08
3236 Semaphorin signaling restricts neuronal regeneration in C. elegans
Harreguy, M. B.; Shah, E.; Tanvir, Z.; Simprevil, B.; Tran, T. S.; Haspel, G.
10.1101/2021.11.13.468479 — neuroscience — Posted on 2022-09-08
3237 Repeated unilateral handgrip contractions alter functional connectivity and improve contralateral limb response times: A neuroimaging study
Andrushko, J. W.; Levenstein, J. M.; Zich, C.; Edmond, E. C.; Campbell, J.; Clarke, W. T.; Emir, U.; Farthing, J. P.; Stagg, C. J.
10.1101/2021.10.23.464569 — neuroscience — Posted on 2022-09-08
3238 Revealing the Neurobiology Underlying Interpersonal Neural Synchronization with Multimodal Data Fusion
Lotter, L. D.; Kohl, S. H.; Gerloff, C.; Bell, L.; Niephaus, A.; Kruppa, J. A.; Dukart, J.; Schulte-Rüther, M.; Reindl, V.; Konrad, K.
10.1101/2022.07.26.501562 — neuroscience — Posted on 2022-09-08
3245 A scenario-guided strategy for the future management of biological invasions
Roura-Pascual, N.; Saul, W.-C.; Perez-Granados, C.; Rutting, L.; Peterson, G. D.; Latombe, G.; Essl, F.; Adriaens, T.; Aldridge, D. C.; Bacher, S.; Bernardo-Madrid, R.; Brotons, L.; Diaz, F.; Gallardo, B.; Genovesi, P.; Golivets, M.; Gonzalez-Moreno, P.; Hall, M.; Kutlesa, P.; Lenzner, B.; Liu, C.; Pagitz, K.; Pastor, T.; Rabitsch, W.; Robertson, P.; Roy, H. E.; Seebens, H.; Solarz, W.; Starfinger, U.; Tanner, R.; Vila, M.; Leung, B.; Garcia-Lozano, C.; Jeschke, J. M.
10.1101/2022.09.07.506838 — ecology — Posted on 2022-09-08
3250 The Phenotype-Genotype Reference Map: Improving biobank data science through replication.
Bastarache, L.; Delozier, S. B.; Pandit, A.; He, J.; Lewis, A.; Annis, A. C.; LeFaive, J.; Denny, J. C.; Carroll, R. J.; Hughey, J. J.; Zawistowski, M.; Peterson, J. F.
10.1101/2022.09.07.506932 — genetics — Posted on 2022-09-08
3252 Edge effects constraint endemic but not introduced arthropod species in a pristine forest on Terceira (Azores, Portugal)
Tsafack, N.; Pozsgai, G.; Boieiro, M.; Ros-Prieto, A.; Nunes, R.; Ferreira, M. T.; Borges, P. A. V.
10.1101/2022.09.07.506827 — ecology — Posted on 2022-09-08
3254 Food for thought: selectivity for food in human ventral visual cortex
Jain, N.; Wang, A.; Henderson, M. M.; Lin, R.; Prince, J. S.; Tarr, M. J.; Wehbe, L.
10.1101/2022.05.22.492983 — neuroscience — Posted on 2022-09-08
3255 Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants
Jetsonen, E.; Didio, G.; Winkel, F.; Llach Pou, M.; Boj, C.; Kuczynski-Noyau, L.; Voikar, V.; Guirado, R.; Taira, T.; Lauri, S. E.; Castren, E.; Umemori, J.
10.1101/2022.09.07.506934 — neuroscience — Posted on 2022-09-08
3258 Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice
Alharbi, H. O.; Hardyman, M. A.; Cull, J. J.; Markou, T.; Cooper, S. T.; Glennon, P. E.; Fuller, S. J.; Sugden, P. H.; Clerk, A.
10.1101/2022.09.07.506723 — physiology — Posted on 2022-09-08
3261 African swine fever virus - variants on the rise
Forth, J. H.; Calvelage, S.; Fischer, M.; Hellert, J.; Sehl-Ewert, J.; Roszyk, H.; Deutschmann, P.; Reichold, A.; Lange, M.; Thulke, H.-H.; Sauter-Louis, C.; Höper, D.; Mandyhra, S.; Sapachova, M.; Beer, M.; Blome, S.
10.1101/2022.09.07.506908 — genomics — Posted on 2022-09-08
3262 DESIGNING OF CUSTOM BARCODES FOR SEQUENCING ON THE MGI PLATFORM
Bulusheva, I.; Shmitko, A.; Vasiliadis, I.; Suchalko, O.; Syrko, D.; Belova, V.; Korostin, D.
10.1101/2022.09.07.506907 — genomics — Posted on 2022-09-08
3263 What does heritability of Alzheimer's disease represent?
Baker, E. A.; Leonenko, G.; Schmidt, K. M.; Hill, M.; Myers, A. J.; Shoai, M.; de Rojas, I.; Tesi, N.; Holstege, H.; van der Flier, W. M.; Pijnenburg, Y. A. L.; Ruiz, A.; Hardy, J.; van der Lee, S.; Escott-Price, V.
10.1101/2022.09.07.506912 — genetics — Posted on 2022-09-08
3266 Functional MRS studies of GABA and Glutamate/Glx: a systematic review and meta-analysis
Pasanta, D.; He, J. L.; Ford, T. C.; Oeltzschner, G.; Lythgoe, D.; Puts, N. A.
10.1101/2022.09.07.506899 — neuroscience — Posted on 2022-09-08
3267 Natural statistics of head roll: implications for Bayesian inference in spatial orientation
Willemsen, S. C. M. J.; Oostwoud Wijdenes, L.; van Beers, R. J.; Koppen, M.; Medendorp, W. P.
10.1101/2022.09.07.506906 — neuroscience — Posted on 2022-09-08
3275 Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies
Nowbandegani, P. S.; Wohns, A. W.; Ballard, J. L.; Lander, E. S.; Bloemendal, A.; Neale, B. M.; O'Connor, L. J.
10.1101/2022.09.06.506858 — genetics — Posted on 2022-09-08
3276 EukProt: A database of genome-scale predicted proteins across the diversity of eukaryotes
Richter, D. J.; Berney, C.; Strassert, J. F. H.; Poh, Y.-P.; Herman, E. K.; Munoz-Gomez, S. A.; Wideman, J. A.; Burki, F.; de Vargas, C.
10.1101/2020.06.30.180687 — evolutionary biology — Posted on 2022-09-08
3277 Associations between brood size, gut microbiome diversity and survival in great tit (Parus major) nestlings
Liukkonen, M.; Hukkanen, M.; Cossin-Sevrin, N.; Stier, A.; Vesterinen, E.; Grond, K.; Ruuskanen, S.
10.1101/2022.09.06.506880 — ecology — Posted on 2022-09-08
3279 siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos
Masuda-Ozawa, T.; Fujita, S.; Nakamura, R.; Watanabe, H.; Kuranaga, E.; Nakajima, Y.-i.
10.1101/2022.03.24.485716 — developmental biology — Posted on 2022-09-08
3283 Joint Learning of Full-structure Noise in Hierarchical Bayesian Regression Models
Hashemi, A.; Cai, C.; Gao, Y.; Ghosh, S.; Müller, K.-R.; Nagarajan, S.; Haufe, S.
10.1101/2021.11.28.470264 — neuroscience — Posted on 2022-09-08
3284 Synaptic status differentially regulates neurofilaments in dendritic spines
Guerth, C.-M.; do Rego Barros Fernandes Lima, M. A.; Cereceda Delgado, A. R.; Macarron, V.; Hubrich, J.; D'Este, E.
10.1101/2022.09.07.506909 — neuroscience — Posted on 2022-09-08
3287 Sex dependence of opioid-mediated responses to subanesthetic ketamine
Di Ianni, T.; Azadian, M. M.; Ewbank, S. N.; Michaelides, M.; Airan, R. D.
10.1101/2022.09.06.506854 — neuroscience — Posted on 2022-09-08
3288 Respiratory strategy at birth initiates distinct lung injury phenotypes in the preterm lamb lung
Pereira-Fantini, P. M.; Ferguson, K.; McCall, K.; Oakley, R.; Perkins, E.; Byars, S. G.; Williamson, N.; Nie, S.; Tingay, D.
10.1101/2022.09.06.506865 — systems biology — Posted on 2022-09-08
3292 DeepVariant calling provides insights into race diversity and its implication for sorghum breeding
Ruperao, P.; Gandham, P.; Odeny, D. A.; Selvanayagam, S.; Thirunavukkarasu, N.; Das, R. R.; Srikanda, M.; Gandhi, H.; Habyarimana, E.; Manyasa, E.; Nebie, B.; Deshpande, S. P.; Rathore, A.
10.1101/2022.09.06.505536 — plant biology — Posted on 2022-09-08
3295 Multi-Omics Analysis of Magnetically Levitated Plasma Biomolecules
Ashkarran, A. A.; Gharibi, H.; Zeki, D. A.; Radu, I.; Khalighinejad, F.; Keyhanian, K.; Abrahamsson, C. K.; Ionete, C.; Saei, A. A.; Mahmoudi, M.
10.1101/2022.09.06.506852 — bioengineering — Posted on 2022-09-08
3298 A time and single-cell resolved model of hematopoiesis
Kucinski, I.; Campos, J.; Barile, M.; Severi, F.; Bohin, N.; Moreira, P. N.; Allen, L.; Lawson, H.; Haltalli, M. L. R.; Kinston, S. J.; O'Carroll, D.; Kranc, K. R.; Göttgens, B.
10.1101/2022.09.07.506735 — cell biology — Posted on 2022-09-08
3299 Actin-driven protrusions generate rapid long-range membrane tension propagation in cells
De Belly, H.; Yan, S.; Borja da Rocha, H.; Ichbiah, S.; Town, J. P.; Turlier, H.; Bustamante, C. J.; Weiner, O. D.
10.1101/2022.09.07.507005 — cell biology — Posted on 2022-09-08
3302 Cell overgrowth during G1 arrest triggers an osmotic stress response and chronic p38 activation to promote cell cycle exit
Crozier, L.; Foy, R.; Adib, R.; Badonyi, M.; Kar, A.; Holt, J. A.; Wilson, R.; Regnault, C.; Whitfield, P.; Marsh, J. A.; Saurin, A. T.; Barr, A. R.; Ly, T.
10.1101/2022.09.08.506843 — cell biology — Posted on 2022-09-08
3303 Proteomic signatures of the serological response to flu vaccination in a large human cohort study
Wu, S.; Pushalkar, S.; Maity, S.; Pressler, M.; Rendleman, J.; Vitrinel, B.; Carlock, M. A.; Ross, T.; Choi, H.; Vogel, C.
10.1101/2022.09.06.506846 — immunology — Posted on 2022-09-08
3304 GOAT: Deep learning-enhanced Generalized Organoid Annotation Tool
Bremer, J. P.; Baumdick, M. E.; Knorr, M. S.; Wegner, L. H. M.; Wesche, J.; Jordan-Paiz, A.; Jung, J. M.; Highton, A. J.; Jäger, J.; Hinrichs, O.; Brias, S.; Niersch, J.; Müller, L.; Schreurs, R. R. C. E.; Koyro, T.; Löbl, S.; Mensching, L.; Konczalla, L.; Niehrs, A.; Vondran, F. W. R.; Schramm, C.; Hölzemer, A.; Oldhafer, K. J.; Königs, I.; Kluge, S.; Perez, D.; Reinshagen, K.; Pals, S. T.; Gagliani, N.; Joosten, S. P.; Topf, M.; Altfeld, M.; Bunders, M. J.
10.1101/2022.09.06.506648 — bioinformatics — Posted on 2022-09-08
3309 Edaphic controls on genome size and GC content of bacteria in soil microbial communities
Chuckran, P. F.; Flagg, C.; Propster, J.; Rutherford, W. A.; Sieradzki, E. T.; Blazewicz, S. J.; Hungate, B. A.; Pett-Ridge, J. A.; Schwartz, E.; Dijkstra, P.
10.1101/2021.11.17.469016 — ecology — Posted on 2022-09-08
3310 Head and Neck Cancer-derived small extracellular vesicles sensitize TRPV1+ neurons to mediate cancer pain
Inyang, K. E.; Evans, C. M.; Heussner, M.; Petroff, M.; Reimers, M.; Vermer, P. D.; Tykocki, N.; Folger, J. K.; Laumet, G.
10.1101/2022.09.06.506411 — neuroscience — Posted on 2022-09-08
3311 Global remapping in granule cells and mossy cells of the mouse dentate gyrus
Kim, S. H.; GoodSmith, D.; Temme, S. J.; Moriya, F.; Ming, G.-l.; Christian, K.; Song, H.; Knierim, J. J.
10.1101/2022.09.06.506812 — neuroscience — Posted on 2022-09-08
3314 Vitamin B12 produced by gut bacteria modulates excitatory neurotransmission
Kang, W. K.; Araya, A.; Fox, B. W.; Thackeray, A.; Schroeder, F. C.; Walhout, A. J. M.; Alkema, M. J.
10.1101/2022.09.06.506833 — neuroscience — Posted on 2022-09-08
3318 Deadly and venomous Lonomia caterpillars are more than the two usual suspects
Gonzalez, C.; Ballesteros-Mejia, L.; Diaz-Diaz, J. M.; Toro-Vargas, D. M.; Amarillo-Suarez, A.; Gey, D.; Leon-Ramos, C. M.; Arias, M.; Tovar, E.; Rivera, N.; Buitrago, L. S.; Pinto-Moraes, R. H.; Sano Martins, I. S.; Decaëns, T.; Gonzalez, M. A.; Kitching, I. J.; Rougerie, R.
10.1101/2022.09.06.506776 — ecology — Posted on 2022-09-08
3321 DeepRetroMoCo: Deep neural network-based Retrospective Motion Correction Algorithm for Spinal Cord functional MRI
Mobarak-Abadi, M.; Mahmoudi-Aznave, A.; Dehghani, H.; Zarei, M.; Vahdat, S.; Doyon, J.; Khatibi, A.
10.1101/2022.09.06.506787 — neuroscience — Posted on 2022-09-08
3323 Behavior shapes retinal motion statistics during natural locomotion
Muller, K. S.; Matthis, J.; Bonnen, K.; Cormack, L. K.; Huk, A.; Hayhoe, M.
10.1101/2022.09.06.506797 — neuroscience — Posted on 2022-09-08
3324 Phase separation-based visualization of protein-protein interactions and kinase activities in plants
Safi, A.; Smagghe, W.; Goncalves, A.; Xu, K.; Fernandez, A. I.; Cappe, B.; Riquet, F.; Mylle, E.; Van Damme, D.; Geelen, D.; De Jaeger, G.; Beeckman, T.; Van Leene, J.; Vanneste, S.
10.1101/2022.09.06.506782 — plant biology — Posted on 2022-09-08
3325 Cystathionine gamma lyase overexpression enhances neovascularization through NAD-dependent mechanisms
Kiesworo, K.; MacArthur, M. R.; Kip, P.; Agius, T.; Macabrey, D.; Lambelet, M.; Hamard, L.; Ozaki, C. K.; Mitchell, J. R.; Deglise, S.; Mitchell, S. J.; Allagnat, F.; Longchamp, A.
10.1101/2022.09.06.506715 — physiology — Posted on 2022-09-08
3326 Fibroblasts generate topographical cues that steer cancer cell migration
Baschieri, F.; Illand, A.; Barbazan, J.; Zajac, O.; Henon, C.; Loew, D.; Dingli, F.; Matic Vignjevic, D.; Leveque-Fort, S.; Montagnac, G.
10.1101/2022.09.06.506801 — cancer biology — Posted on 2022-09-08
3329 Reorganizing Niche Architecture Still Preserves Organ Function in the Hair Follicle
Wei, H.; Du, S.; Parksong, J.; Pasolli, H. A.; Regot, S.; Gonzalez, L. E.; Xin, T.; Greco, V.
10.1101/2022.09.06.506764 — developmental biology — Posted on 2022-09-08
3331 Evolution of schooling propensity in the guppy drives changes in anti-predator behavior that are linked to neuroanatomy
Corral-Lopez, A.; Kotrschal, A.; Szorkovszky, A.; Garate-Olaizola, M.; Herbert-Read, J.; van der Bijl, W.; Romenskyy, M.; Zeng, H.-L.; Buechel, S. D.; Fontrodona-Eslava, A.; Pelckmans, K.; Mank, J. E.; Kolm, N.
10.1101/2022.09.07.506928 — evolutionary biology — Posted on 2022-09-08
3332 Early suppression of excitability in subcortical band heterotopia modifies epileptogenesis in rats
Hardy, D.; Buhler, E.; Suchkov, D.; Vinck, A.; Fortoul, A.; Watrin, F.; Represa, A.; Minlebaev, M.; Manent, J.-B.
10.1101/2022.09.06.506850 — neuroscience — Posted on 2022-09-08
3333 A parabrachial-to-amygdala circuit that determines hemispheric lateralization of somatosensory processing
Allen, H. N.; Chaudhry, S.; Hong, V. M.; Lewter, L. A.; Sinha, G. P.; Carrasquillo, Y.; Taylor, B.; Kolber, B. J.
10.1101/2022.09.06.506763 — neuroscience — Posted on 2022-09-08
3334 Noradrenergic cross-modular reciprocal inhibition within the Locus Coeruleus.
Davy, O.; Perrins, R.; Lavigne, M.; Kremer, E.; Tsaneva-Atanasova, K.; Ashby, M.; Hirschberg, S.; Pickering, A. E.
10.1101/2022.09.07.506929 — neuroscience — Posted on 2022-09-08
3335 Low forces push the maturation of neural precursors into neurons
de Vincentiis, S.; Baggiani, M.; Merighi, F.; Cappello, V.; Lopane, J.; Di Caprio, M.; Costa, M.; Mainardi, M.; Onorati, M.; Raffa, V.
10.1101/2022.09.07.507054 — neuroscience — Posted on 2022-09-08
3336 Cognition through internal models: Mirror neurons as one manifestation of a broader mechanism
Aflalo, T.; Chivukula, S.; Zhang, C.; Rosario, E. R.; Pouratian, N.; Andersen, R. A.
10.1101/2022.09.06.506071 — neuroscience — Posted on 2022-09-08
3337 The genetics of cortical organisation and development: a study of 2,347 neuroimaging phenotypes
Warrier, V.; Stauffer, E.-M.; Huang, Q. Q.; Wigdor, E. M.; Slob, E. A. W.; Seidlitz, J.; Ronan, L.; Valk, S. L.; Mallard, T. T.; Grotzinger, A. D.; Romero-Garcia, R.; Baron-Cohen, S.; Geschwind, D. H.; Lancaster, M.; Murray, G. K.; Gandal, M. J.; Alexander-Bloch, A.; Won, H.; Martin, H. C.; Bullmore, E. T.; Bethlehem, R. A. I.
10.1101/2022.09.08.507084 — neuroscience — Posted on 2022-09-08
3340 Microliter spotting and micro-colony observation: a rapid and simple approach for counting bacterial colony-forming units
Bhuyan, S.; Yadav, M.; Giri, S. J.; Begum, S.; Das, S.; Phukan, A.; Priyadarshani, P.; Sarkar, S.; Jayswal, A.; Kabyashree, K.; Kumar, A.; Mandal, M.; Ray, S. K.
10.1101/2022.01.26.477842 — microbiology — Posted on 2022-09-08
3342 Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors
Bhin, J.; Paes Dias, M.; Gogola, E.; Rolfs, F.; Piersma, S. R.; de Bruijn, R.; de Ruiter, J.; van den Broek, B.; Duarte, A.; Sol, W.; van der Heijden, I.; Bakker, L.; Kaiponen, T. S.; Lieftink, C.; Morris, B.; Beijersbergen, R. L.; van de Ven, M.; Jimenez, C. R.; Wessels, L. F. A.; Rottenberg, S.; Jonkers, J.
10.1101/2022.09.07.506927 — cancer biology — Posted on 2022-09-07
3346 Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy
Sayin, S.; Rosener, B.; Li, C. G.; Ho, B.; Ponomarova, O.; Ward, D.; Walhout, A. J.; Mitchell, A.
10.1101/2022.09.07.506952 — systems biology — Posted on 2022-09-07
3347 Topical GZ21T inhibits the growth of actinic keratoses in a UVB induced model of skin carcinogenesis
Bordeaux, Z. A.; Choi, J.; Braun, G.; Davis, C.; Marani, M.; Lee, K.; Samuel, C.; Adams, J.; Windom, R.; Kambala, A.; Cornman, H.; Reddy, S. V.; Pollizzi, A.; LU, W.; Oladipo, O. O.; Alphonse, M. P.; West, C. E.; Kwatra, S. G.; Kwatra, M. M.
10.1101/2022.09.07.506864 — cancer biology — Posted on 2022-09-07
3348 Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila
Bosch, J. A.; Ugur, B.; Pichardo-Casas, I.; Rabasco, J.; Escobedo, F.; Zuo, Z.; Brown, B.; Celniker, S.; Sinclair, D.; Bellen, H. J.; Perrimon, N.
10.1101/2020.07.01.182485 — genomics — Posted on 2022-09-07
3350 Phase separation of Myc differentially regulates gene transcription
Yang, J.; Chung, C.-I.; Koach, J.; Liu, H.; Zhao, Q.; Yang, X.; Shen, Y.; Weiss, W. A.; Shu, X.
10.1101/2022.06.28.498043 — cell biology — Posted on 2022-09-07
3351 GRAS-1 is a conserved novel regulator of early meiotic chromosome dynamics in C. elegans
Martinez-Garcia, M.; Robles, P.; Skinner, M. W.; Baran, K. A.; Nadarajan, S.; Shin, N.; Silva-Garcia, C. G.; Saito, T. T.; Beese-Sims, S.; Castaner, A.; Pacheco, S.; Martinez-Perez, E.; Jordan, P. W.; Colaiacovo, M. P.
10.1101/2022.09.06.506874 — cell biology — Posted on 2022-09-07
3352 Single-cell Total RNA Miniaturized sequencing (STORM-seq) reveals differentiation trajectories of primary human fallopian tube epithelium
Johnson, B. K.; Rhodes, M.; Wegener, M.; Himadewi, P.; Foy, K.; Schipper, J. L.; Siwicki, R. A.; Rossell, L. L.; Siegwald, E. J.; Chesla, D. W.; Teixeira, J. M.; Sheridan, R. T. C.; Adams, M.; Triche, T. J.; Shen, H.
10.1101/2022.03.14.484332 — molecular biology — Posted on 2022-09-07
3353 Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice
Sams, K. L.; Mukai, C.; Marks, B. A.; Mittal, C.; Demeter, E. A.; Nelissen, S.; Grenier, J. K.; Tate, A. E.; Ahmed, F.; Coonrod, S. A.
10.1101/2022.02.09.479603 — molecular biology — Posted on 2022-09-07
3354 Microliter spotting and micro-colony observation: a rapid and simple approach for counting bacterial colony-forming units
Bhuyan, S.; Yadav, M.; Giri, S. J.; Begum, S.; Das, S.; Phukan, A.; Priyadarshani, P.; Sarkar, S.; Jayswal, A.; Kabyashree, K.; Kumar, A.; Mandal, M.; Ray, S. K.
10.1101/2022.01.26.477842 — microbiology — Posted on 2022-09-07
3355 Microglia protect fungi against copper starvation and promote brain infection
Mohamed, S. H.; Fu, M. S.; Hain, S.; Alselami, A.; Vanhoffelen, E.; Li, Y.; Bojang, E.; Lukande, R.; Ballou, E. R.; May, R. C.; Ding, C.; Vande Velde, G.; Drummond, R. A.
10.1101/2022.09.07.506901 — immunology — Posted on 2022-09-07
3356 A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells
Thomas, M.; Martin, O.; Bruzeau, C.; Pollet, J.; Bender, S.; Carrion, C.; Le Noir, S.; Pinaud, E.
10.1101/2022.09.06.506747 — immunology — Posted on 2022-09-07
3357 Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells
Berryer, M. H.; Tegtmeyer, M.; Binan, L.; Valakh, V.; Nathanson, A.; Trendafilova, D.; Crouse, E.; Klein, J.; Meyer, D.; Pietilainen, O.; Rapino, F.; Farhi, S.; Rubin, L. L.; McCarroll, S.; Nehme, R.; Barrett, L. E.
10.1101/2022.09.07.507028 — neuroscience — Posted on 2022-09-07
3360 GDF15 antagonism limits severe heart failure and prevents cardiac cachexia in mice
Takaoka, M.; Tadross, J. A.; Al-Hadithi, A.; Villena-Gutierrez, R.; Tromp, J.; Absar, S.; Au, M.; Harrison, J.; Coll, A. P.; Marciniak, S. J.; Rimmington, D.; Oliver, E.; Ibanez, B.; Voors, A. A.; O'Rahilly, S.; Mallat, Z.; Goodall, J. C.
10.1101/2022.09.06.506633 — pathology — Posted on 2022-09-07
3361 Disruption of the MYC Super-Enhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Yashar, W. M.; Smith, B. M.; Coleman, D. J.; VanCampen, J.; Kong, G.; Macaraeg, J.; Estabrook, J.; Demir, E.; Long, N.; Bottomly, D.; McWeeney, S. K.; Tyner, J. W.; Druker, B. J.; Maxson, J. E.; Braun, T. P.
10.1101/2022.01.17.476469 — cancer biology — Posted on 2022-09-07
3362 A novel cancer-associated cassette exon in TLN1 alters Talin 1 mechanosensitivity
Gallego-Paez, L. M.; Edwards, W. J. S.; Guo, Y.; Chanduri, M.; Koorman, T.; Lee, C.-Y.; Grexa, N.; Derksen, P. W. B.; Yan, J.; Schwartz, M. A.; Mauer, J.; Goult, B. T.
10.1101/2022.09.06.506802 — cancer biology — Posted on 2022-09-07
3363 Efficacy and safety of glycosphingolipid SSEA-4 targeting CAR-T cells in solid tumors
Monzo, H.; Hyytiäinen, M.; Elbasani, E.; Kalander, K.; Wall, J.; Moyano-Galceran, L.; Tanjore Ramanathan, J.; Jukonen, J.; Laakkonen, P.; Ristimäki, A.; Carlson, J.; Lehti, K.; Salehi, S.; Puolakkainen, P.; Haglund, C.; Seppänen, H.; Leppa, S.; Ojala, P. M.
10.1101/2022.09.02.506335 — cancer biology — Posted on 2022-09-07
3365 Learning epistatic polygenic phenotypes with Boolean interactions
Behr, M.; Kumbier, K.; Cordova-Palomera, A.; Aguirre, M.; Ashley, E.; Butte, A.; Arnaout, R.; Brown, J. B.; Preist, J.; Yu, B.
10.1101/2020.11.24.396846 — bioinformatics — Posted on 2022-09-07
3367 Three-dimensional organization of chromatin associated RNAs and their role in chromatin architecture in human cells
Calandrelli, R.; Wen, X.; Charles Richard, J. L.; Luo, Z.; Nguyen, T. C.; Chen, C.-J.; Qi, Z.; Xue, S.; Chen, W.; Yan, Z.; Wu, W.; Zaleta-Rivera, K.; Hu, R.; Yu, M.; Wang, Y.; Li, W.; Ma, J.; Ren, B.; Zhong, S.
10.1101/2021.06.10.447969 — genomics — Posted on 2022-09-07
3374 The Intestinal Microbiome, Dietary Habits, and Physical and Psychological Resilience in Postpartum Women
Matsunaga, M.; Takeuchi, M.; Watanabe, S.; Takeda, A. K.; Kikusui, T.; Mogi, K.; Nagasawa, M.; Hagihara, K.; Myowa, M.
10.1101/2022.09.07.506896 — microbiology — Posted on 2022-09-07
3376 A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4+ T cell profile
Sannier, G.; Nicolas, A.; Dube, M.; Marchitto, L.; Nayrac, M.; Tastet, O.; Tauzin, A.; Lima-Barbosa, R.; Laporte, M.; Cloutier, R.; Flores, A. S.; Boutin, M.; Gong, S. Y.; Benlarbi, M.; Ding, S.; Bourassa, C.; Gendron-Lepage, G.; Medjahed, H.; Goyette, G.; Brassard, N.; Ortega-Delgado, G.-G.; Niessl, J.; Gokool, L.; Morrisseau, C.; Arlotto, P.; Rios, N.; Tremblay, C.; Martel-Laferriere, V.; Prat, A.; Belair, J.; Beaubien-Souligny, W.; Goupil, R.; Nadeau-Fredette, A.-C.; Lamarche, C.; Finzi, A.; Suri, R.; Kaufmann, D. E.
10.1101/2022.09.05.506622 — immunology — Posted on 2022-09-07
3378 MultiOMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells
Pinto, S. M.; Subbannayya, Y.; Kim, H.; Hagen, L.; Gorna, M. W.; Nieminen, A. I.; Bjoras, M.; Espevik, T.; Kainov, D. E.; Kandasamy, R. K.
10.1101/2022.09.06.506768 — systems biology — Posted on 2022-09-07
3379 Red light-emitting short Mango-based system enables tracking a mycobacterial small noncoding RNA in infected macrophages
Bychenko, O.; Khrulev, A. A.; Svetlova, J. I.; Tsvetkov, V. B.; Kamzeeva, P. N.; Skvortsova, Y.; Tupertsev, B. S.; Ivanov, I. A.; Aseev, L. V.; Khodarovich, Y. M.; Belyaev, E. S.; Kozlovskaya, L. I.; Zatsepin, T. S.; Azhikina, T. L.; Varizhuk, A. M.; Aralov, A. V.
10.1101/2022.09.07.506834 — synthetic biology — Posted on 2022-09-07
3380 Wheat EARLY FLOWERING3 is a dawn-expressed circadian oscillator component that regulates heading date
Wittern, L.; Steed, G.; Taylor, L. J.; Cano Ramirez, D.; Pingarron-Cardenas, G.; Greenland, A.; Gardner, K.; Hannah, M. A.; Webb, A. A. R.
10.1101/2021.09.03.458922 — plant biology — Posted on 2022-09-07
3381 Molecular determinants of dynamic protein-protein interactions in the functional cycle of the membrane protein DsbD
Stelzl, L. S.; Kritsiligkou, P.; Mehdipour, A. R.; Baldwin, A. J.; Ferguson, S. J.; Mavridou, D. A. I.; Sansom, M. S. P.; Redfield, C.
10.1101/2022.09.07.506916 — biophysics — Posted on 2022-09-07
3384 CaMKII activity spreads by inter-holoenzyme phosphorylation
Lucic, I.; Heluin, L.; Jiang, P.-L.; Castro Scalise, A. G.; Wang, C.; Franz, A.; Wahl, M.; Liu, F.; Plested, A. J. R.
10.1101/2022.08.03.502606 — biophysics — Posted on 2022-09-07
3388 Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors
Moore, A.; Busch, M. P.; Dziewulska, K.; Francis, R. O.; Hod, E. A.; Zimring, J. C.; D'Alessandro, A.; Page, G. P.
10.1101/2022.09.07.506936 — biochemistry — Posted on 2022-09-07
3390 Future COVID-19 surges prediction based on SARS-CoV-2 mutations surveillance
Najar, F.; Linde, E.; Murphy, C.; Borin, V.; Wang, H.; Haider, S.; Agarwal, P.
10.1101/2022.09.05.506640 — genomics — Posted on 2022-09-07
3391 The native mussel Mytilus chilensis genome reveals adaptative molecular signatures facing the marine environment.
Gallardo-Escarate, C.; Valenzuela-Munoz, V.; Nunez-Acuna, G.; Valenzuela-Miranda, D.; Tapia, F.; Yevenes, M.; Gajardo, G.; Toro, J. E.; Oyarzun, P. A.; Arriagada, G.; novoa, b.; Figueras, A.; Roberts, S.; Gerdol, M.
10.1101/2022.09.06.506863 — genomics — Posted on 2022-09-07
3392 A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics
Pandey, A. C.; Bezney, J.; DeAscanis, D.; Kirsch, E.; Ahmed, F.; Crinklaw, A.; Choudhary, K. S.; Mandala, T.; Deason, J.; Hamdi, J.; Siddique, A.; Ranganathan, S.; Ordoukhanian, P.; Brown, K.; Armstrong, J.; Head, S.; Topol, E. J.
10.1101/2022.09.06.506867 — genetics — Posted on 2022-09-07
3394 Phagocytosis underpins the biotrophic lifestyle of intracellular parasites in the class Phytomyxea (Rhizaria)
Garvetto, A.; Murua, P.; Kirchmair, M.; Salvenmoser, W.; Hittorf, M.; Ciaghi, S.; Harikrishnan, S. L.; Gachon, C. M. M.; Burns, J. A.; Neuhauser, S.
10.1101/2022.09.07.506935 — microbiology — Posted on 2022-09-07
3396 Fluid flow sensitizes bacterial pathogens to chemical stress
Padron, G. C.; Shuppara, A. M.; Sharma, A.; Koch, M. D.; Palalay, J.-J. S.; Radin, J. N.; Kehl-Fie, T. E.; Imlay, J. A.; Sanfilippo, J. E.
10.1101/2022.09.07.506966 — microbiology — Posted on 2022-09-07
3398 Defining antigen targets to dissect vaccinia virus (VACV) and Monkeypox virus (MPXV)-specific T cell responses in humans
Grifoni, A.; Zhang, Y.; Tarke, A.; Sidney, J.; Rubiro, P.; Reina-Campos, M.; Filaci, G.; Dan, J. M.; Scheuermann, R. H.; Sette, A.
10.1101/2022.09.06.506534 — immunology — Posted on 2022-09-07
3399 Immunogenicity and Protective Efficacy of a SARS-CoV-2 mRNA Vaccine Encoding Secreted Non-Stabilized Spike Protein in Mice
Prompetchara, E.; Ketloy, C.; Alameh, M. G.; Tarakhet, K.; Kaewpang, P.; Yostrerat, N.; Pitakpolrat, P.; Buranapraditkun, S.; Manopwisedcharoen, S.; Thitithanyanont, A.; Jongkaewwattana, A.; Hunsawong, T.; Im-Erbsin, R.; Reed, M.; Wijagkanalan, W.; Patarakul, K.; Palaga, T.; Lam, K.; Heyes, J.; Weissman, D.; Ruxrungtham, K.
10.1101/2022.09.07.506878 — immunology — Posted on 2022-09-07
3400 Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice
Janic, A.; Strasser, A.; Herold, M.; Brennan, M. S.; Healey, G.; Gangoda, L.; Brinkmann, K.
10.1101/2022.09.06.506741 — cancer biology — Posted on 2022-09-07
3401 Fusion-negative Rhabdomyosarcoma 3D-organoids as an innovative model to predict resistance to cell death inducers
Savary, C.; Huchede, P.; Luciana, L.; Tourbez, A.; Deligne, C.; Picard, C.; Diot, T.; Coquet, C.; Meynard, N.; Le Grand, M.; Tonon, L.; Gadot, N.; Degletagne, C.; Leon, S.; Attignon, V.; Boman, A.; Rochet, I.; Muller, K.; Mournetas, V.; Bergeron, C.; Rinaudo, P.; Dutour, A.; Cordier-Bussat, M.; Dijoud, F.; Corradini, N.; Maucort-Boulch, D.; Pasquier, E.; Blay, J.-Y.; Castets, M.; Broutier, L.
10.1101/2022.09.06.506756 — cancer biology — Posted on 2022-09-07
3403 Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network
Martinez-Riano, A.; Wang, S.; Boeing, S.; Minoughan, S.; Casal, A.; Spillane, K. M.; Ludewig, B.; Tolar, P.
10.1101/2022.09.06.506650 — immunology — Posted on 2022-09-07
3404 A report card methodology to showcase progress towards threatened species recovery
Ward, M.; Rout, T.; Stewart, R.; Possingham, H.; McDonald-Madden, E.; Clarke, T.; Valentine, L.; Kindler, G.; Macmillan, E.; Watson, J.
10.1101/2022.09.06.506545 — scientific communication and education — Posted on 2022-09-07
3405 Investigating the risk of cardiac fibrosis due to heat-not-burn cigarettes through human cardiac stromal cells
Chimenti, I.; Picchio, V.; Pagano, F.; Carnevale, R.; D'Amico, A.; Cozzolino, C.; Floris, E.; Bordin, A.; Schirone, L.; saade, w.; Miraldi, F.; De Falco, E.; Sciarretta, S.; Peruzzi, M.; Biondi-Zoccai, G.; Frati, G.
10.1101/2022.09.06.506632 — pathology — Posted on 2022-09-07
3406 ETV7 reduces inflammatory responses in breast cancer cells by repressing TNFR1/NF-kappaB axis
Meskyte, E. M.; Pezze, L.; Forcato, M.; Bocci, I. A.; Bisio, A.; Bicciato, S.; Baltriukiene, D.; Ciribilli, Y.
10.1101/2022.09.06.506542 — cancer biology — Posted on 2022-09-07
3409 Extending protein interaction networks using proteoforms and small molecules
Hernandez Sanchez, L. F.; Burger, B.; Castro Campos, R. A.; Johansson, S.; Njolstad, P. R.; Barsnes, H.; Vaudel, M.
10.1101/2022.09.06.506730 — bioinformatics — Posted on 2022-09-07
3415 The establishment of Populus x Laccaria bicolor ectomycorrhiza requires the inactivation of MYC2 coordinated defense response with a key role for root terpene synthases
Marques-Galvez, J. E.; Basso, V.; Kohler, A.; Barry, K.; Keymanesh, K.; Johnson, J.; Singan, V.; Grigoriev, I.; Vilgalys, R.; Martin, F.; Veneault-Fourrey, C.
10.1101/2022.09.06.505662 — plant biology — Posted on 2022-09-07
3418 Initial niche condition determines the aging speed and regenerative activity of quiescent cells
Liu, Q.; Sheng, N.; Zhang, Z.; He, C.; Zhao, Y.; Sun, H.; Chen, J.; Yang, X.; Tang, C.
10.1101/2022.09.06.506737 — cell biology — Posted on 2022-09-07
3419 Mechanisms of mRNA processing defects in inherited THOC6 intellectual disability syndrome
Werren, E. A.; LaForce, G. R.; Srivastava, A.; Perillo, D. R.; Johnson, K.; Berger, B.; Baris, S.; Regan, S. L.; Pfennig, C. D.; de Munnik, S.; Pfundt, R.; Hebbar, M.; Jimenez-Heredia, R.; Karakoc-Aydiner, E.; Ozen, A.; Dmytrus, J.; Krolo, A.; Corning, K.; Prijoles, E.; Louie, R.; Lebel, R.; Le, T.-L.; Gordon, C.; Girish, K. M.; Boztug, K.; Shukla, A.; Bielas, S. L.; Schaffer, A. E.
10.1101/2022.09.06.506502 — molecular biology — Posted on 2022-09-07
3425 Global Phylogeny of the Brassicaceae Provides Important Insights into Gene Discordance
Hendriks, K. P.; Kiefer, C.; Al-Shehbaz, I. A.; Bailey, C. D.; Hooft van Huysduynen, A. A. C.; Nikolov, L.; Nauheimer, L.; Zuntini, A. R.; German, D. A.; Franzke, A.; Koch, M. A.; Lysak, M. A.; Toro-Nunez, O.; Ozudogru, B.; Invernon, V. R.; Walden, N.; Maurin, O.; Hay, N.; Sushkov, P.; Mandakova, T.; Thulin, M.; Windham, M.; Resetnik, I.; Spaniel, S.; Ly, E.; Pires, J. C.; Harkess, A.; Neuffer, B.; Vogt, R.; Braeuchler, C.; Rainer, H.; Janssens, S.; Schmull, M.; Forrest, A.; Guggisberg, A.; Zmarzty, S.; Lepschi, B.; Scarlett, N.; Stauffer, F. W.; Schonberger, I.; Heenan, P.; Baker, W. J.; Fore
10.1101/2022.09.01.506188 — evolutionary biology — Posted on 2022-09-07
3427 High-risk microbial signatures are associated with severe parasitemia in controlled Plasmodium infections of both humans and rhesus macaques
Gustin, A. T.; Broedlow, C. A.; Coronado, E.; Wangari, S.; Iwayama, N.; Ahrens, C. Y.; Garrison, W. D.; Guerriero, K. A.; De Paris, K.; Gale, M.; Klatt, N. R.; Kublin, J. G.; Manuzak, J. A.
10.1101/2022.09.06.506695 — microbiology — Posted on 2022-09-07
3428 Enterococcal linear plasmids adapt to Enterococcus faecium and spread within multidrug-resistant clades.
Hashimoto, Y.; Suzuki, M.; Kobayashi, S.; Hirahara, Y.; Nomura, T.; Kurushima, J.; Hirakawa, H.; Tanimoto, K.; Tomita, H.
10.1101/2022.09.07.506885 — microbiology — Posted on 2022-09-07
3430 High resolution analysis of the cytosolic Ca2+ events in beta cell collectives in situ
Postic, S.; Sarikas, S.; Pfabe, J.; Pohorec, V.; Krizancic Bombek, L.; Sluga, N.; Skelin Klemen, M.; Dolensek, J.; Korosak, D.; Stozer, A.; Evans-Molina, C.; Johnson, J. D.; Slak Rupnik, M.
10.1101/2021.04.14.439796 — physiology — Posted on 2022-09-07
3432 Coronary artery established through amniote evolution
Mizukami, K.; Higashiyama, H.; Arima, Y.; Ando, K.; Fukuhara, S.; Miyagawa-Tomita, S.; Kurihara, H.
10.1101/2022.09.06.506796 — evolutionary biology — Posted on 2022-09-07
3434 Genomic loss of the HSP70cA gene in the vertebrate lineage
Merchant, A.; Ramirez, B. I.; Reyes, M. N.; Van, D.; Martinez-Colin, M.; Ojo, D. O.; Mazuca, E. L.; De La O, H. J.; Glenn, A. M.; Lira, C. G.; Ehsan, H.; Yu, E.; Kaneko, G.
10.1101/2022.09.06.506793 — evolutionary biology — Posted on 2022-09-07
3436 Wolbachia genomics support a tripartite nutritional symbiosis in blood-sucking Triatomine bugs
Filee, J.; Agesilas-Lequeux, K.; Lacquehay, L.; Berenger, J. M.; Dupont, L.; Mendonca, V.; Aristeu da Rosa, J.; Harry, M.
10.1101/2022.09.06.506778 — evolutionary biology — Posted on 2022-09-07
3437 Flexible communication between cell assemblies and 'reader' neurons
Boucly, C. J.; Pompili, M. N.; Todorova, R.; Leroux, E. M.; Wiener, S.; Zugaro, M.
10.1101/2022.09.06.506754 — neuroscience — Posted on 2022-09-07
3438 Motor Cortex Projections To Red Nucleus And Pons Have Distinct Functional Roles In The Mouse
Lopez-Virgen, V.; Macias, M.; Rodriguez-Moreno, P.; Olivares-Moreno, R.; de Lafuente, V.; Concha, L.; Rojas-Piloni, G.
10.1101/2022.09.06.506669 — neuroscience — Posted on 2022-09-07
3440 Activation of the fear-responsive anterior hypothalamic area promotes avoidance and triggers compulsive grooming behavior in mice
Laing, B. T.; Anderson, M. S.; Jayan, A.; Park, A. S.; Erbaugh, L. J.; Solis, O.; Wilson, D. J.; Michaelides, M.; Aponte, Y.
10.1101/2022.09.06.506804 — neuroscience — Posted on 2022-09-07
3443 Clinically oriented prediction of patient response to targeted and immunotherapies from the tumor transcriptome
Dinstag, G.; Shulman, E. D.; Elis, E.; Ben-Zvi, D. S.; Tirosh, O.; Maimon, E.; Meilijson, I.; Elalouf, E.; Temkin, B.; Vitkovsky, P.; Schiff, E.; Hoang, D.-T.; Sinha, S.; Nair, N. U.; Sang Lee, J.; Schaffer, A. A.; Ronai, Z.; Juric, D.; Apolo, A. B.; Dahut, W. L.; Lipkowitz, S.; Berger, R.; Kurzrock, R.; Papanicolau-Sengos, A.; Karzai, F.; Gilbert, M. R.; Aldape, K.; Rajagopal, P. S.; Beker, T.; Ruppin, E.; Aharonov, R.
10.1101/2022.02.27.481627 — bioinformatics — Posted on 2022-09-06
3444 Molecular characterization of the intact muscle spindle using a multi-omics approach
Bornstein, B.; Heinemann-Yerushalmi, L.; Krief, S.; Adler, R.; Dassa, B.; Leshkowitz, D.; Kim, M.; Bewick, G.; Banks, R. W.; Zelzer, E.
10.1101/2022.07.13.499888 — developmental biology — Posted on 2022-09-06
3447 Predicting predator-prey interactions in terrestrial endotherms using random forest
Llewelyn, J.; Strona, G.; Dickman, C. R.; Greenville, A.; Wardle, G.; Lee, M. S. Y.; Doherty, S.; Shabani, F.; Saltre, F.; Bradshaw, C. J. A.
10.1101/2022.09.02.506446 — ecology — Posted on 2022-09-06
3448 Di-valent siRNA Mediated Silencing of MSH3 Blocks Somatic Repeat Expansion in Mouse Models of Huntington's Disease
O'Reilly, D.; Belgrad, J.; Ferguson, C.; Summers, A.; Sapp, E.; McHugh, C.; Mathews, E.; Buchwald, J.; Ly, S.; Echeverria Moreno, D.; Kennedy, Z.; Hariharan, V.; Monopoli, K.; Yang, X.; Carroll, J.; Difiglia, M.; Aronin, N.; Khvorova, A.
10.1101/2022.09.06.506795 — molecular biology — Posted on 2022-09-06
3450 Corticostriatal Beta Power Changes Associated with Cognitive Function in Parkinsons Disease
Paulo, D. L.; Qian, H.; Subramanian, D.; Johnson, G. W.; Hett, K.; Kao, C.; Roy, N.; Dhima, K.; Claassen, D. O.; Bick, S. K.
10.1101/2022.07.07.499165 — neuroscience — Posted on 2022-09-06
3452 A novel cancer-associated cassette exon in TLN1 alters Talin 1 mechanosensitivity
Gallego-Paez, L. M.; Edwards, W. J. S.; Guo, Y.; Chanduri, M.; Koorman, T.; Lee, C.-Y.; Grexa, N.; Derksen, P. W. B.; Yan, J.; Schwartz, M. A.; Mauer, J.; Goult, B. T.
10.1101/2022.09.06.506802 — cancer biology — Posted on 2022-09-06
3454 Development and application of a computable genotype model in the GA4GH Variation Representation Specification
Goar, W.; Babb, L.; Chamala, S.; Cline, M.; Freimuth, R. R.; Hart, R. K.; Kuzma, K.; Lee, J.; Nelson, T.; Prlic, A.; Riehle, K.; Smith, A.; Stahl, K.; Yates, A. D.; Rehm, H. L.; Wagner, A. H.
10.1101/2022.09.06.506817 — bioinformatics — Posted on 2022-09-06
3456 Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patients
Bourque, K.; Derish, I.; Hawey, C.; Jones-Tabah, J.; Khan, K.; Alim, K.; Jiang, A.; Sadighian, H.; Zwaig, J.; Gendron, N.; Cecere, R.; Giannetti, N.; Hebert, T.
10.1101/2022.09.06.506800 — biochemistry — Posted on 2022-09-06
3457 Noninvasive, low-cost RNA-sequencing enhances discovery potential of transcriptome studies
Martorella, M.; Kasela, S.; Garcia-Flores, R.; Gokden, A.; Castel, S. E.; Lappalainen, T.
10.1101/2022.09.06.506813 — genomics — Posted on 2022-09-06
3459 Generation of floxed alleles for cell-specific knockout in zebrafish
Shin, M.; Nozaki, T.; Toles, B.; Kolb, A.; Luk, K.; Isogai, S.; Ishida, K.; Hanasaka, T.; Parsons, M. J.; Wolfe, S. A.; Lawson, N. D.
10.1101/2022.09.06.506849 — genetics — Posted on 2022-09-06
3460 Msh2-Msh3 interferes with DNA metabolism in vivo
Medina-Rivera, M.; Sridharan, M.; Becker, J.; Phelps, S.; Lamb, N. A.; Kumar, C.; Cornaire, M.; Sutton, M. D.; Bielinsky, A. K.; Balakrishnan, L.; Surtees, J. A.
10.1101/2022.09.06.506750 — genetics — Posted on 2022-09-06
3463 D-mannose ameliorates age-associated cellular senescence in the bladder urothelium and NLRP3/Gasdermin/IL-1β -driven pyroptotic epithelial cell shedding
Joshi, C. S.; Salazar, A. M.; Wang, C.; Ligon, M. M.; Chappidi, R. R.; Fashemi, B. E.; Felder, P. A.; Mora, A.; Grimm, S. L.; Coarfa, C.; Mysorekar, I. U.
10.1101/2022.09.06.506836 — cell biology — Posted on 2022-09-06
3464 Redefining normal breast cell populations using long noncoding RNAs
Bitar, M.; Rivera, I. S.; Pimentel de Almeida, I.; Shi, W.; Ferguson, K.; Beesley, J.; Lakhani, S.; Edwards, S.; French, J. D.
10.1101/2022.09.06.506112 — cell biology — Posted on 2022-09-06
3465 Targeted insertion of reporter transgene into a gene safe harbor in human blood fluke, Schistosoma mansoni
Tanno, W. I.; Moscheid, M. F.; Chaparro, C.; Mann, V. H.; Quack, T.; Rodpai, R.; Miller, A. N.; Wistiphongpun, P.; Buakaew, W.; Mentink-Kane, M.; Miller, L.; Schmid, S.; Popratiloff, A.; Grevelding, C.; Grunau, C.; Brindley, P. J.
10.1101/2022.09.02.506379 — molecular biology — Posted on 2022-09-06
3466 Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/Omicron variants following an inactivated whole-virus vaccine
Lu, C.; Zhang, Y.; Liu, X.; Hou, F.; Cai, R.; Yu, Z.; Liu, F.; Yang, G.; Ding, J.; Xu, J.; Hua, X.; Pan, X.; Liu, L.; Lin, K.; Wang, Z.; Li, X.; Lu, J.; Zhang, Q.; Li, Y.; Hu, C.; Fan, H.; Liu, X.; Wang, H.; Jia, R.; Xu, F.; Wang, X.; Huang, H.; Zhao, R.; Li, J.; Cheng, H.; Jia, W.; Yang, X.
10.1101/2022.09.06.506714 — molecular biology — Posted on 2022-09-06
3469 Quantitative physiology and proteome adaptations of Bifidobacterium breve NRBB57 at near-zero growth rates
Ortiz Camargo, A. R.; van Mastrigt, O.; Bongers, R.; BenAmor, K.; Knol, J.; Abee, T.; Smid, E. J.
10.1101/2022.09.06.506712 — microbiology — Posted on 2022-09-06
3471 Immune dynamics at single cell protein level after delta/omicron infection in COVID-19 vaccinated convalescent individuals
Bajaj, R.; Yang, Z.; Hammer, V.; Poeschel, S.; Beiber, K.; Salker, M. S.; Casadei, N.; Ossowski, S.; Riess, O.; Singh, Y.
10.1101/2022.09.05.506626 — immunology — Posted on 2022-09-06
3472 CRISPR screens in 3D assembloids reveal disease genes associated with human interneuron development
Meng, X.; Yao, D.; Kelley, K. W.; Reis, N.; Thete, M. V.; Kulkarni, S.; Bassik, M. C.; Pasca, S. P.
10.1101/2022.09.06.506845 — neuroscience — Posted on 2022-09-06
3473 GDF15 antagonism limits severe heart failure and prevents cardiac cachexia in mice
Takaoka, M.; Tadross, J. A.; Al-Hadithi, A.; Villena-Gutierrez, R.; Tromp, J.; Absar, S.; Au, M.; Harrison, J.; Coll, A. P.; Marciniak, S. J.; Rimmington, D.; Oliver, E.; Ibanez, B.; Voors, A. A.; O'Rahilly, S.; Mallat, Z.; Goodall, J. C.
10.1101/2022.09.06.506633 — pathology — Posted on 2022-09-06
3475 Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin opening
Hayat, A.; Carter, E.; King, H. W.; Ors, A.; Doe, A.; Teijeiro, S. A.; Charrot, S.; Godinho, S.; Cutillas, P. R.; Mohammed, H.; Grose, R. P.; Ficz, G.
10.1101/2022.09.06.506760 — cancer biology — Posted on 2022-09-06
3476 Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
Lu, Y.; Cho, T.; Mukherjee, S.; Malik, A. A.; Gonzalez-Foutel, N.; Suarez, C. F.; Derovic, D.; Oh, R. H.; Langille, E.; Al-Zahrani, K.; Lin, Z.; Tsai, R.; Rotter, V.; Ashton-Prolla, P.; Chemes, L. B.; Moffat, J.; Gingras, A.-C.; Oren, M.; Durocher, D.; Schramek, D.
10.1101/2022.03.13.483372 — cancer biology — Posted on 2022-09-06
3478 Cardiovascular Hemodynamics in Mice with Tumor Necrosis Factor Receptor - Associated Factor 2 Mediated Cytoprotection in the Heart
Marshall, A. G.; Neikirk, K.; Vue, Z.; Beasley, H. K.; Garza-Lopez, E.; Vang, L.; Barongan, T.; Evans, Z.; Anudokem, J.; Pham, T. T.; Gomez, J. A.; Exil, V.; Dai, D.-F.; Entman, M. L.; Taffet, G. E.; Hinton, A.; Reddy, A. K.
10.1101/2022.09.03.506447 — biophysics — Posted on 2022-09-06
3479 CALANGO: a phylogeny-aware comparative genomics tool for discovering quantitative genotype-phenotype associations across species
Hongo, J. A.; de Castro, G. M.; Menezes, A. P. A.; Rios Picorelli, A. C.; Martins da Silva, T. T.; Imada, E. L.; Marchionni, L.; Del-Bem, L.-E.; Chaves, A. V.; Almeida, G.; Campelo, F.; Pereira Lobo, F.
10.1101/2021.08.25.457574 — bioinformatics — Posted on 2022-09-06
3481 Effective use of genetically-encoded optical biosensors for profiling signalling signatures in iPSC-CMs derived from idiopathic dilated cardiomyopathy patients
Bourque, K.; Derish, I.; Hawey, C.; Jones-Tabah, J.; Khan, K.; Alim, K.; Jiang, A.; Sadighian, H.; Zwaig, J.; Gendron, N.; Cecere, R.; Giannetti, N.; Hebert, T.
10.1101/2022.09.06.506800 — biochemistry — Posted on 2022-09-06
3483 A single cell atlas of the cycling murine ovary
Morris, M. E.; Meinsohn, M.-C.; Chauvin, M.; Saatcioglu, H. D.; Kashiwagi, A.; Sicher, N. A.; Nguyen, N.; Yuan, S.; Stavely, R. G.; Hyun, M.; Donahoe, P. K.; Sabatini, B. L.; Pepin, D.
10.1101/2022.02.08.479522 — developmental biology — Posted on 2022-09-06
3484 Single molecule co-occupancy of RNA-binding proteins with an evolved RNA deaminase
Lin, Y.; Kwok, S.; Thai, B. Q.; Alabi, Y.; Ostrowski, M.; Wu, K.; Floor, S. N.
10.1101/2022.09.06.506853 — molecular biology — Posted on 2022-09-06
3485 Resistance of SARS-CoV-2 Omicron Subvariant BA.4.6 to Antibody Neutralization
Wang, Q.; Li, Z.; Ho, J.; Guo, Y.; Yeh, A. Y.; Liu, M.; Wang, M.; Yu, J.; Sheng, Z.; Liu, L.; Ho, D. D.
10.1101/2022.09.05.506628 — microbiology — Posted on 2022-09-06
3486 Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics
Chio, H.; Guest, E. E.; Hobman, J. L.; Dottorini, T.; Hirst, J. D.; Stekel, D. J.
10.1101/2022.09.06.506739 — microbiology — Posted on 2022-09-06
3487 Omicron-induced interferon signalling prevents influenza A virus infection
Bojkova, D.; Bechtel, M.; Rothenburger, T.; Kandler, J. D.; Hayes, L.; Olmer, R.; Martin, U.; Jonigk, D.; Ciesek, S.; Wass, M. N.; Michaelis, M.; Cinatl, J.
10.1101/2022.09.06.506799 — microbiology — Posted on 2022-09-06
3488 Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity
Amano, T.; Yu, H.; Amano, M.; Leyder, E.; Badiola, M.; Ray, P.; Kim, J.; Ko, A. C.; Achour, A.; Weng, N.-p.; Kochba, E.; Levin, Y.; Ko, M. S. H.
10.1101/2022.09.05.506686 — immunology — Posted on 2022-09-06
3489 KLC4 shapes axon arbors during development and mediates adult behavior
Haynes, E. M.; Burnett, K. H.; He, J.; Jean-Pierre, M.; Jarzyna, M.; Eliceiri, K. W.; Huisken, J.; Halloran, M.
10.1101/2021.09.26.461872 — neuroscience — Posted on 2022-09-06
3490 A Principal Odor Map Unifies Diverse Tasks in Human Olfactory Perception
Lee, B. K.; Mayhew, E. J.; Sanchez-Lengeling, B.; Wei, J. N.; Qian, W. W.; Little, K.; Andres, M.; Nguyen, B. B.; Moloy, T.; Parker, J. K.; Gerkin, R. C.; Mainland, J. D.; Wiltschko, A. B.
10.1101/2022.09.01.504602 — neuroscience — Posted on 2022-09-06
3491 The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular network
Vandal, M.; Institoris, A.; Korin, B.; Gunn, C.; Lee, S.; Lee, J.; Bourassa, P.; Mishra, R. C.; Peringod, G.; Jiang, Y.; Hirai, S.; Belzil, C.; Reveret, L.; Tremblay, C.; Hashem, M.; Elias, E.; Meilandt, W.; Foreman, O.; Rouse-Girma, M.; Muruve, D.; Nicola, W.; Korbelin, J.; Dunn, J. F.; Braun, A. P.; Bennett, D. A.; Gordon, G. R.; Calon, F.; Shaw, A. S.; Nguyen, M. D.
10.1101/2020.12.10.419598 — neuroscience — Posted on 2022-09-06
3492 Pump-less, recirculating organ-on-a-chip (rOoC) platform
Busek, M.; Aizenshtadt, A.; Koch, T.; Frank, A.; Delon, L.; Amirola-Martinez, M.; Golovin, A.; Dumas, C.; Stokowiec, J.; Gruenzner, S.; Melum, E.; Krauss, S.
10.1101/2022.09.06.506239 — bioengineering — Posted on 2022-09-06
3495 Bayesian inference of admixture graphs on Native American and Arctic populations
Nielsen, S. V.; Vaughn, A.; Leppälä, K.; Landis, M. J.; Mailund, T.; Nielsen, R.
10.1101/2022.09.06.506725 — genetics — Posted on 2022-09-06
3498 Meningeal IL-17 producing T cells mediate cognitive impairment in salt-sensitive hypertension
Santisteban, M. M.; Faraco, G.; Brea Lopez, D.; Wang, G.; Sobanko, M. J.; Sciortino, R.; Racchumi, G.; Waisman, A.; Anrather, J.; Iadecola, C.
10.1101/2022.09.05.506398 — neuroscience — Posted on 2022-09-06
3499 Sleep spindle maturation enhances slow oscillation-spindle coupling
Joechner, A.-K.; Hahn, M. A.; Gruber, G.; Hoedlmoser, K.; Werkle-Bergner, M.
10.1101/2022.09.05.506664 — neuroscience — Posted on 2022-09-06
3500 The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses
Lenz, M.; Eichler, A.; Kruse, P.; Galanis, C.; Kleidonas, D.; Jedlicka, P.; Müller, U.; Deller, T.; Vlachos, A.
10.1101/2022.09.05.506635 — neuroscience — Posted on 2022-09-06
3502 Neural cognitive signals during spontaneous movements in the macaque
Tremblay, S.; Testard, C.; DiTullio, R. W.; Inchauspe, J.; Petrides, M.
10.1101/2022.09.05.506681 — neuroscience — Posted on 2022-09-06
3505 MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and edema in intracerebral hemorrhage
Akeret, K.; Buzzi, R. M.; Thomson, B. R.; Schwendinger, N.; Klohs, J.; Schulthess, N.; Baselgia, L.; Hansen, K.; Regli, L.; Vallelian, F.; Hugelshofer, M.; Schaer, D.
10.1101/2022.09.06.506660 — neuroscience — Posted on 2022-09-06
3506 The PROSCOOP10 gene encodes two extracellular hydroxylated peptides and impacts flowering time in Arabidopsis
Guillou, M.-C.; Balliau, T.; Vergne, E.; Canut, H.; Chourre, J.; Herrera-Leon, C.; Ramos-Martin, F.; Ahmadi-Afzadi, M.; D'Amelio, N.; Ruelland, E.; Zivy, M.; Renou, J.-P.; Jamet, E.; Aubourg, S.
10.1101/2022.09.06.506713 — plant biology — Posted on 2022-09-06
3507 Acquisition of hybrid E/M phenotype associated with increased migration, drug resistance and stemness is mediated by reduced miR-18a levels in ER-negative breast cancer
Nair, M. G.; D, A.; M, C.; VP, S.; CE, A.; Rajarajan, S.; Sahoo, S.; Mohan, G.; Jayakumar, V. S.; Ramesh, R. S.; BS, S.; Jolly, M. K.; Maliekal, T. T.; Prabhu, J. S.
10.1101/2022.09.05.505398 — cancer biology — Posted on 2022-09-06
3511 MAGE enables population level RNAseq driven genotyping and (differential) allelic divergence detection in healthy kidney and carcinoma
Stroobandt, C.; Goovaerts, T.; Coussement, L.; De Graeve, F.; Voorthuijzen, F.; Van Steenbergen, L.; Galle, J.; Van Criekinge, W.; De Meyer, T.
10.1101/2022.09.06.506720 — bioinformatics — Posted on 2022-09-06
3514 A machine learning liver-on-a-chip system for safer drug formulation
Shi, Y.; Lin, C.-H.; Reker, D.; Steiger, C.; Hess, K.; Collins, J. E.; Tamang, S.; Ishida, K.; Lopes, A.; Wainer, J.; Hayward, A. M.; Walesky, C.; Goessling, W.; Traverso, G.
10.1101/2022.09.05.506668 — bioengineering — Posted on 2022-09-06
3517 intra-single cell sequencing (iSCseq) spotlights transcriptomic and epigenetic heterogeneity inside multinucleated osteoclast
Okada, H.; Terui, Y.; Omata, Y.; Seki, M.; Tani, S.; Miyahara, J.; Makabe, K.; Terashima, A.; Kanazawa, S.; Hosonuma, M.; Yano, F.; Kajiya, H.; Saito, T.; Suzuki, Y.; Okabe, K.; Baron, R.; Tanaka, S.; Chung, U.-i.; Hojo, H.
10.1101/2022.09.05.506360 — genomics — Posted on 2022-09-06
3520 The relationship between spectral and plant diversity: disentangling the influence of metrics and habitat types
Perrone, M.; Di Febbraro, M.; Conti, L.; Divisek, J.; Chytry, M.; Keil, P.; Carranza, M. L.; Rocchini, D.; Torresani, M.; Moudry, V.; Simova, P.; Prajzlerova, D.; Müllerova, J.; Wild, J.
10.1101/2022.09.05.506583 — ecology — Posted on 2022-09-06
3521 Self-assembly of cellular neighborhoods converts stochastic signaling into sustained olfactory neurogenesis
Rajan, S. G.; Lombardo, J. N.; Nacke, L. M.; Manuchehrfar, F.; Wong, K.; Garcia, J.; Liang, J.; Saxena, A.
10.1101/2022.09.05.506659 — developmental biology — Posted on 2022-09-06
3522 Unravelling the impact of aging on the human endothelial lncRNA transcriptome
Drekolia, M.-K.; Talyan, S.; Cordellini Emidia, R.; Boon, R. A.; Guenther, S.; Looso, M.; Dumbovic, G.; Bibli, S.-I.
10.1101/2022.09.05.506634 — cell biology — Posted on 2022-09-06
3524 Spreading depolarization causes reperfusion failure after cerebral ischemia
Torteli, A.; Toth, R.; Berger, S. D.; Samardzic, S.; Bari, F.; Menyhart, A.; Farkas, E.
10.1101/2022.09.05.506665 — neuroscience — Posted on 2022-09-06
3525 Multi-Echo Investigations of Positive and Negative CBF and Concomitant BOLD Changes
Devi, R.; Lepsien, J.; Lorenz, K.; Schlumm, T.; Mildner, T.; Möller, H. E.
10.1101/2022.09.05.506629 — neuroscience — Posted on 2022-09-06
3527 High-Resolution Magnetization-Transfer Imaging of Post-Mortem Marmoset Brain: Comparisons with Relaxometry and Histology
Marschner, H.; Pampel, A.; Müller, R.; Reimann, K.; Bock, N.; Morawski, M.; Geyer, S.; Möller, H. E.
10.1101/2022.09.05.506600 — neuroscience — Posted on 2022-09-06
3529 Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice
Torres Irizarry, V. C.; Feng, B.; Yang, X.; Patel, N.; Schaul, S.; Ibrahimi, L.; Ye, H.; Luo, P.; Carrillo Saenz, L.; Lai, P.; Kota, M.; Dixit, D.; Wang, C.; Lasek, A. W.; He, Y.; Xu, P.
10.1101/2022.09.05.506646 — neuroscience — Posted on 2022-09-06
3541 EzMechanism: An Automated Tool to Propose Catalytic Mechanisms of Enzyme Reactions
Ribeiro, A. J. M.; Riziotis, I. G.; Tyzack, J. D.; Borkakoti, N.; Thornton, J. M.
10.1101/2022.09.05.506575 — bioinformatics — Posted on 2022-09-06
3546 ChimeraTE: A pipeline to detect chimeric transcripts derived from genes and transposable elements
Siqueira Oliveira, D.; Fablet, M.; Larue, A.; Vallier, A.; Aparecida Carareto, C.; Rebollo, R.; Vieira, C.
10.1101/2022.09.05.505575 — bioinformatics — Posted on 2022-09-06
3547 TransporterPAL: An integrative database Transporter Prediction ALgorithm
Dyekjaer, J. D.; Andersen, A. K. B.; Madsen, J. A. V.; Morth, J. P.; Jensen, L. J.; Borodina, I.
10.1101/2022.09.05.506577 — bioinformatics — Posted on 2022-09-06
3550 BBB-on-a-chip with Integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer's disease
Palma Florez, S. F.; Lopez-Canosa, A.; Morales-Zavala, F.; Castano, O.; Kogan, M. J.; Samitier, J.; Lagunas, A.; Mir, M.
10.1101/2022.09.05.505851 — bioengineering — Posted on 2022-09-06
3551 The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1
Corfield, E. C.; Frei, O.; Shadrin, A. A.; Rahman, Z.; Lin, A.; Athanasiu, L.; Cevdet Akdeniz, B.; Hannigan, L.; Wootton, R. E.; Austerberry, C.; Hughes, A.; Tesli, M.; Westlye, L. T.; Stefansson, H.; Stefansson, K.; Njolstad, P. R.; Magnus, P.; Davies, N. M.; Appadurai, V.; Hemani, G.; Hovig, E.; Zayats, T.; Ask, H.; Reichborn-Kjennerud, T.; Andreassen, O. A.; Havdahl, A.
10.1101/2022.06.23.496289 — genetics — Posted on 2022-09-06
3552 Rad51-mediated interhomolog recombination during budding yeast meiosis is promoted by the meiotic recombination checkpoint and the conserved Pif1 helicase
Ziesel, A.; Weng, Q.; Ahuja, J. S.; Bhattacharya, A.; Dutta, R.; Cheng, E.; Börner, G. V.; Lichten, M.; Hollingsworth, N. M.
10.1101/2022.09.05.506590 — genetics — Posted on 2022-09-06
3553 The influence of genetic structure on phenotypic diversity in the Australian mango (Mangifera indica) gene pool
Wilkinson, M. J.; Yamashita, R.; James, M. E.; Bally, I. S. E.; Dillon, N. L.; Ali, A.; Hardner, C. M.; Ortiz-Barrientos, D.
10.1101/2022.09.04.506567 — evolutionary biology — Posted on 2022-09-06
3554 Convergent selection on juvenile hormone signaling is associated with the evolution of eusociality in bees
Jones, B. M.; Rubin, B. E.; Dudchenko, O.; Kingwell, C. J.; Traniello, I. M.; Wang, Z. Y.; Kapheim, K. M.; Wyman, E. S.; Adastra, P. A.; Liu, W.; Parsons, L. R.; Jackson, S. R.; Goodwin, K.; Davidson, S. M.; McBride, M. J.; Webb, A. E.; Omufwoko, K. S.; Van Dorp, N.; Fernandez Otarola, M.; Pham, M.; Omer, A. D.; Weisz, D.; Schraiber, J.; Villanea, F.; Wcislo, W. T.; Paxton, R. J.; Hunt, B. G.; Aiden, E. L.; Kocher, S. D.
10.1101/2021.04.14.439731 — evolutionary biology — Posted on 2022-09-06
3555 Individual variation in the avian gut microbiota: the influence of host state and environmental heterogeneity
Somers, S. E.; Davidson, G. L.; Johnson, C. N.; Reichert, M. S.; Crane, J. M. S.; Ross, R. P.; Stanton, C.; Quinn, J. L.
10.1101/2022.09.05.506623 — ecology — Posted on 2022-09-06
3558 A note on discretising Keyfitz entropy
de Vries, C.; Bernard, C.; Salguero-Gomez, R.
10.1101/2022.09.05.506601 — ecology — Posted on 2022-09-06
3559 Exposure to global change and microplastics elicits an immune response in an endangered coral
Bove, C. B.; Greene, K.; Sugierski, S.; Kriefall, N. G.; Huzar, A. K.; Hughes, A. M.; Sharp, K.; Fogarty, N. D.; Davies, S. W.
10.1101/2022.09.05.506609 — ecology — Posted on 2022-09-06
3560 Design principles for selective polarization of PAR proteins by cortical flows
Illukkumbura, R.; Hirani, N.; Borrego-Pinto, J.; Bland, T.; Ng, K.; Hubatsch, L.; McQuade, J.; Endres, R.; Goehring, N.
10.1101/2022.09.05.506621 — cell biology — Posted on 2022-09-06
3563 Molecular fate-mapping of serum antibodies reveals the effects of antigenic imprinting on repeated immunization
Schiepers, A.; van 't Wout, M. F.; Greaney, A. J.; Zang, T.; Muramatsu, H.; Lin, P. J.; Tam, Y. K.; Mesin, L.; Starr, T. N.; Bieniasz, P. D.; Pardi, N.; Bloom, J. D.; Victora, G. D.
10.1101/2022.08.29.505743 — immunology — Posted on 2022-09-06
3564 Reduction of the HIV-1 reservoir in T cells from persons with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells ex vivo
Checkley Luttge, M. A.; LUTTGE, B. G.; Dobrowolski, C.; Wald, D. N.; McMahon, D.; Haidar, G.; Sobolewski, M. D.; Enick, P. N.; Cyktor, J.; Mellors, J. W.; Karn, J.
10.1101/2022.09.05.506592 — immunology — Posted on 2022-09-06
3565 Microglia mediate synaptic plasticity induced by 10 Hz repetitive transcranial magnetic stimulation
Eichler, A.; Kleidonas, D.; Turi, Z.; Fliegauf, M.; Kirsch, M.; Pfeifer, D.; Masuda, T.; Prinz, M.; Lenz, M.; Vlachos, A.
10.1101/2021.10.03.462905 — neuroscience — Posted on 2022-09-06
3567 The Tripod neuron: a minimal structural reduction of the dendritic tree
Quaresima, A.; Duarte, R.; Fitz, H.; van den Broek, D.; Hagoort, P.; Petersson, K. M.
10.1101/2022.09.05.506197 — neuroscience — Posted on 2022-09-06
3568 Metamodelling of a two-population spiking neural network
Skaar, J.-E. W.; Stasik, A. J.; Plesser, H. E.; Einevoll, G. T.; Tondel, K.
10.1101/2022.09.05.506616 — neuroscience — Posted on 2022-09-06
3569 Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty, H.; Moberly, A. H.; Lohani, S.; Barson, D.; Coifman, R. R.; Mishne, G.; Cardin, J. A.; Higley, M. J.
10.1101/2021.08.15.456390 — neuroscience — Posted on 2022-09-06
3572 Warmer temperatures result in maladaptive learning of sexual preferences
Holveck, M.-J.; Muller, D.; Visser, B.; Timmermans, A.; Colonval, L.; Jan, F.; Crucifix, M.; Nieberding, C.
10.1101/2020.11.05.369561 — evolutionary biology — Posted on 2022-09-06
3574 SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer's-like neuropathology
Shen, W.-B.; Elahi, M.; Logue, J.; Yang, P.; Baracco, L.; Reece, E. A.; Wang, B.; Li, L.; Blanchard, T.; Han, Z.; Frieman, M.; Rissman, R. A.; Yang, P.
10.1101/2022.01.31.478476 — neuroscience — Posted on 2022-09-06
3575 Learning inverse folding from millions of predicted structures
Hsu, C.; Verkuil, R.; Liu, J.; Lin, Z.; Hie, B.; Sercu, T.; Lerer, A.; Rives, A.
10.1101/2022.04.10.487779 — systems biology — Posted on 2022-09-06
3576 Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir
Hu, Y.; Lewandowski, E. M.; Tan, H.; Morgan, R. T.; Zhang, X.; Jacobs, L. M.; Butler, S. G.; Mongora, M. V.; Choy, J. S.; Chen, Y.; Wang, J.
10.1101/2022.06.28.497978 — pharmacology and toxicology — Posted on 2022-09-06
3577 Introgression between highly divergent sea squirt genomes: an adaptive breakthrough?
Fraisse, C.; Le Moan, A.; Roux, C.; Dubois, G.; Daguin-Thiebaut, C.; Gagnaire, P.-A.; Viard, F.; Bierne, N.
10.1101/2022.03.22.485319 — evolutionary biology — Posted on 2022-09-06
3579 Vertical gradients in photosynthetic physiology diverge at the latitudinal range extremes of white spruce
Schmiege, S. C.; Griffin, K. L.; Boelman, N. T.; Vierling, L. A.; Bruner, S. G.; Min, E.; Maguire, A. J.; Jensen, J.; Eitel, J. U. H.
10.1101/2022.05.06.490824 — ecology — Posted on 2022-09-06
3581 Representations of complex contexts: A role for hippocampus
Dimsdale-Zucker, H. R.; Montchal, M. E.; Reagh, Z. M.; Wang, S.-F.; Libby, L. A.; Ranganath, C. R.
10.1101/766311 — neuroscience — Posted on 2022-09-06
3584 Efficacy and safety of glycosphingolipid SSEA-4 targeting CAR-T cells in solid tumors
Monzo, H.; Hyytiäinen, M.; Elbasani, E.; Kalander, K.; Wall, J.; Moyano-Galceran, L.; Tanjore Ramanathan, J.; Jukonen, J.; Laakkonen, P.; Ristimäki, A.; Carlson, J.; Lehti, K.; Salehi, S.; Puolakkainen, P.; Haglund, C.; Seppänen, H.; Leppa, S.; Ojala, P. M.
10.1101/2022.09.02.506335 — cancer biology — Posted on 2022-09-06
3585 Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage
Ghasemi, D. R.; Okonechnikov, K.; Rademacher, A.; Tirier, S.; Maass, K. K.; Schumacher, H.; Sundheimer, J.; Statz, B.; Rifaioglu, A. S.; Bauer, K.; Schumacher, S.; Bortolomeazzi, M.; Giangaspero, F.; Ernst, K. J.; Saez-Rodriguez, J.; Jones, D. T. W.; Kawauchi, D.; Mallm, J.-P.; Rippe, K.; Korshunov, A.; Pfister, S. M.; Pajtler, K. W.
10.1101/2022.09.02.506321 — cancer biology — Posted on 2022-09-06
3586 Continental-scale hyperspectral tree species classification in the United States National Ecological Observatory Network
Marconi, S.; Weinstein, B. G.; Zou, S.; Bohlman, S. A.; Zare, A.; Singh, A.; Stewart, D.; Harmon, I.; Steinkraus, A.; White, E. P.
10.1101/2021.12.22.473714 — ecology — Posted on 2022-09-06
3588 Integrated human-machine interface for closed-loop stimulation using implanted and wearable devices
Sladky, V.; Kremen, V.; McQuown, K.; Mivalt, F.; Brinkmann, B.; van Gompel, J.; Miller, K. J.; Denison, T.; Worrell, G. A.
10.1101/2022.09.04.506494 — neuroscience — Posted on 2022-09-06
3589 Metaplasticity: Dark exposure boosts excitability and visual plasticity in adult human cortex
Min, S. H.; Wang, Z.; Chen, M.; Hu, R.; Gong, L.; He, Z.; Wang, X.; Hess, R. F.; Zhou, J.
10.1101/2022.09.04.506561 — neuroscience — Posted on 2022-09-06
3594 Cardiovascular Hemodynamics in Mice with Tumor Necrosis Factor Receptor - Associated Factor 2 Mediated Cytoprotection in the Heart
Marshall, A. G.; Neikirk, K.; Vue, Z.; Beasley, H. K.; Garza-Lopez, E.; Vang, L.; Barongan, T.; Evans, Z.; Anudokem, J.; Pham, T. T.; Gomez, J. A.; Exil, V.; Dai, D.-F.; Entman, M. L.; Taffet, G. E.; Hinton, A.; Reddy, A. K.
10.1101/2022.09.03.506447 — biophysics — Posted on 2022-09-06
3596 Sea lamprey nests promote the diversity of benthic macroinvertebrate assemblages
Dhamelincourt, M.; Rives, J.; Pons, M.; Larranaga, A.; Tentelier, C.; Elosegi, A.
10.1101/2022.09.04.506553 — ecology — Posted on 2022-09-06
3597 Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration
Salinas-saavedra, M.; Febrimarsa, F.; Krasovec, G.; Horkan, H. R.; Baxevanis, A. D.; Frank, U.
10.1101/2022.09.02.506310 — developmental biology — Posted on 2022-09-06
3599 WiNGS: Widely integrated NGS platform for federated genome analysis
Chizari, H.; Sattanathan, N.; Ardeshirdavani, A.; Shabani, N.; Huremagic, B.; Vermeesch, J. R.; Moreau, Y.; Vandeweyer, G.
10.1101/2022.06.23.497325 — bioinformatics — Posted on 2022-09-06
3601 Glucose oxidation and nutrients availability drive neural crest development
Nekooie-Marnany, N.; Fodil, R.; Fereol, S.; Depp, M.; Motterlini, R.; Foresti, R.; Duband, J.-L.; Dufour, S.
10.1101/2022.09.05.506657 — developmental biology — Posted on 2022-09-06
3602 The impact of genetic risk for Alzheimers disease on the structural brain networks of young adults
Mirza-Davies, A.; Foley, S.; Caseras, X.; Baker, E.; Holmans, P.; Escott-Price, V.; Jones, D. K.; Harrison, J. R.; Messaritaki, E.
10.1101/2021.09.22.461338 — neuroscience — Posted on 2022-09-06
3603 Scream's roughness confers a privileged access to the brain during sleep
Legendre, G. Y. T.; Moyne, M.; Dominguez-Borras, J.; Kumar, S.; Sterpenich, V.; Schwartz, S.; Arnal, L.
10.1101/2022.09.05.506631 — neuroscience — Posted on 2022-09-06
3607 Attenuation hotspots in neurotropic human astroviruses
Ali, H.; Lulla, A.; Nicholson, A. S.; Wignall-Fleming, E. B.; OConnor, R. L.; Vu, D.-L.; Graham, S. C.; Deane, J. E.; Guix, S.; Lulla, V.
10.1101/2022.09.06.506719 — microbiology — Posted on 2022-09-06
3611 Computational modelling of cambium activity provides a regulatory framework for simulating radial plant growth
Lebovka, I.; Hay Mele, B.; Liu, X.; Zakieva, A.; Schlamp, T.; Gursanscky, N.; Merks, R. M. H.; Grosseholz, R.; Greb, T.
10.1101/2020.01.16.908715 — plant biology — Posted on 2022-09-06
3612 PD-L1ATTAC mice reveal the potential of targeting PD-L1 expressing cells in cancer therapy
Fueyo-Marcos, E.; Fustero-Torre, C.; Lopez, G.; Anton, M. E.; Al-Shahrour, F.; Fernandez-Capetillo, O.; Murga, M.
10.1101/2022.07.22.501095 — cancer biology — Posted on 2022-09-06
3617 Metamorphosis imposes variable constraints on genome expansion
Mueller, R. L.; Cressler, C. E.; Schwarz, R. S.; Chong, R. A.; Butler, M. A.
10.1101/2021.05.05.442795 — evolutionary biology — Posted on 2022-09-06
3618 Copy number variations shape the structural diversity of Arabidopsis metabolic gene clusters and are associated with the climatic gradient
Marszalek-Zenczak, M.; Satyr, A.; Wojciechowski, P.; Zenczak, M.; Sobieszczanska, P.; Brzezinski, K.; Iefimenko, T.; Figlerowicz, M.; Zmienko, A.
10.1101/2022.09.05.506152 — genomics — Posted on 2022-09-05
3619 Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response
Arora, R.; Cao, C.; Kumar, M.; Sinha, S.; Chanda, A.; McNeil, R.; Samuel, D.; Arora, R. K.; Matthew, T. W.; Chandarana, S.; Hart, R.; Dort, J. C.; Biernaskie, J.; Neri, P.; Hyrcza, M. D.; Bose, P.
10.1101/2022.09.04.505581 — cancer biology — Posted on 2022-09-05
3620 Oocyte and cumulus cell cooperativity and metabolic plasticity under the direction of oocyte paracrine factors
Richani, D.; Poljak, A.; Wang, B.; Mahbub, S. B.; Biazik, J.; Campbell, J. M.; Habibalahi, A.; Stocker, W. A.; Marinova, M. B.; Nixon, B.; Bustamante, S.; Skerrett-Byrne, D. A.; Harrison, C. A.; Goldys, E.; Gilchrist, R. B.
10.1101/2022.09.05.506599 — developmental biology — Posted on 2022-09-05
3622 STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria
Wang, Y.; Rivera, F.; Edwards, C.; Frame, T.; Engel, J. A.; Bukali, L.; Na, J.; Ng, S.; Corvino, D.; Montes de Oca, M.; Bunn, P.; Soon, M.; Andrew, D.; Loughland, J.; Amante, F.; Barber, B.; McCarthy, J. S.; Lopez, J. A.; Boyle, M. J.; Engwerda, C.
10.1101/2022.09.04.506109 — immunology — Posted on 2022-09-05
3623 Scavenger receptor B1 facilitates the endocytosis of Escherichia coli via TLR4 signaling in mammary gland infection
Taban, Q.; Ahmad, S. M.; Mumtaz, P. T.; Bhat, B.; Haq, E.; Magray, S.; Saleeem, S.; Shabir, N.; Muhee, A.; Kashoo, Z. A.; Hameed, M.; Malik, A.; Ganai, N. A.; Shah, R. A.
10.1101/2022.09.05.506597 — immunology — Posted on 2022-09-05
3624 Membrane Targeted Azobenzene Drives Optical Modulation of Bacterial Membrane Potential
de Souza-Guerreiro, T. C.; Bondelli, G.; Grobas, I.; Donini, S.; Sesti, V.; Bertarelli, C.; Lanzani, G.; Asally, M.; Paterno, G. M.
10.1101/2022.09.05.506195 — biophysics — Posted on 2022-09-05
3625 An Alpha-helical Lid Guides the Target DNA toward Catalysis in CRISPR-Cas12a
Saha, A.; Ahsan, M.; Arantes, P. R.; Schmitz, M.; Chanez, C.; Jinek, M.; Palermo, G.
10.1101/2022.09.05.506663 — biophysics — Posted on 2022-09-05
3627 Chorography and conformational dynamism of the Soluble Human Fibrinogen in solution
Sen, M.; Hudson, N. E.; Offenbacher, A. R.; Iavarone, A. T.; Nguyen, Q.; Ray, K.; Popovic, G.; Manandhar, P.; Pinelo, J. E. E.
10.1101/2022.09.05.506423 — biochemistry — Posted on 2022-09-05
3628 Reducing the Complexity of Fc Glycan Enables the Construction of Antibody Conjugates with Unexpected High Efficiency and Payload Capacity via Glycoengineering
Yang, Y.; Song, Z. t.; Tian, T.; Zhao, Z.; Chen, J.; Hu, J. p.; Jiang, X.; Yang, G. l.; Xue, Q.; Zhao, X. l.; Sha, W. x.; Yang, Y.; Li, J. P.
10.1101/2022.09.04.506510 — biochemistry — Posted on 2022-09-05
3629 The cytidine deaminase APOBEC3G drives cancer mutagenesis and clonal evolution in bladder cancer
Liu, W.; Newhall, K. P.; Khani, F.; Barlow, L.; Nguyen, D.; Gu, L.; Eng, K.; Bhinder, B.; Uppal, M.; Recapet, C.; Sboner, A.; Ross, S. R.; Elemento, O.; Chelico, L.; Faltas, B. M.
10.1101/2022.09.05.503899 — genomics — Posted on 2022-09-05
3631 Universal DNA methylation age across mammalian tissues
Lu, A. T.; Fei, Z.; Haghani, A.; Robeck, T. R.; Zoller, J. A.; Li, C. Z.; Lowe, R.; Yan, Q.; Zhang, J.; Vu, H.; Ableava, J.; Acosta-Rodriguez, V. A.; Adams, D. M.; Almunia, J.; Aloysius, A.; Ardehali, R.; Arneson, A.; Baker, C. S.; Banks, G.; Belov, K.; Bennett, N. C.; Black, P.; Blumstein, D. T.; Bors, E. K.; Breeze, C. E.; Brooke, R. T.; Brown, J. L.; Carter, G.; Caulton, A.; Cavin, J. M.; Chakrabarti, L.; Chatzistamou, I.; Chen, H.; Cheng, K.; Chiavellini, P.; Choi, O.-W.; Clarke, S.; Cooper, L. N.; Cossette, M.-L.; Day, J.; DeYoung, J.; DiRocco, S.; Dold, C.; Ehmke, E. E.; Emmons, C. K.; E
10.1101/2021.01.18.426733 — developmental biology — Posted on 2022-09-05
3634 A novel role for cystathionine gamma lyase in the control of p53: impact on endothelial senescence and metabolic reprograming
Hu, J.; Leisegang, M. S.; Looso, M.; Dumbovic, G.; Wittig, J.; Drekolia, M.-K.; Guenther, S.; John, D.; Siragusa, M.; Zukunft, S.; Oo, J.; Wittig, I.; Hille, S.; Weigert, A.; Knapp, S.; Brandes, R. P.; Mueller, O. J.; Papapetropoulos, A.; Sigala, F.; Dobreva, G.; Fleming, I.; Bibli, S. I.
10.1101/2022.09.05.506654 — cell biology — Posted on 2022-09-05
3636 The mitochondrial Cu+ transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro
McCann, C.; Quinteros, M.; Adelugba, I.; Morgada, M. N.; Castelblanco, A. R.; Davis, E.; Lanzirotti, A.; Hainer, S. J.; Vila, A. J.; Navea, J. G.; PADILLA-BENAVIDES, T.
10.1101/2022.09.05.506690 — cell biology — Posted on 2022-09-05
3638 STORM-seq Reveals Differentiation Trajectories of Primary Human Fallopian Tube Epithelium
Johnson, B. K.; Rhodes, M.; Wegener, M.; Himadewi, P.; Foy, K.; Schipper, J. L.; Siwicki, R. A.; Rossell, L. L.; Siegwald, E. J.; Chesla, D. W.; Sheridan, R. T. C.; Adams, M.; Triche, T. J.; Shen, H.
10.1101/2022.03.14.484332 — molecular biology — Posted on 2022-09-05
3639 The injury-induced circular RNA circGLIS3 activates dermal fibroblasts to promote wound healing
Toma, M.-A.; Wang, Q.; Li, D.; Xiao, Y.; Niu, G.; Geara, J.; Vij, M.; Piipponen, M.; Liu, Z.; Zhang, L.; Bian, X.; Wang, A.; Sommar, P.; Xu Landen, N.
10.1101/2022.09.05.506337 — molecular biology — Posted on 2022-09-05
3640 Nucleotide level linkage of transcriptional elongation and polyadenylation
Geisberg, J. V.; Moqtaderi, Z.; Fong, N.; Erickson, B.; Bentley, D.; Struhl, K.
10.1101/2022.09.05.506603 — molecular biology — Posted on 2022-09-05
3641 Rgs1 is a regulator of effector gene expression during plant infection by the rice blast fungus Magnaporthe oryzae
Tang, B.; Yan, X.; Ryder, L. S.; Cruz-Mireles, N.; Soanes, D. M.; Molinari, C.; Foster, A. J.; Talbot, N. J.
10.1101/2022.09.04.506535 — molecular biology — Posted on 2022-09-05
3642 Autophagy alterations in white and brown adipose tissues of mice exercised under different training protocols
Tamargo-Gomez, I.; Fernandez-Sanjurjo, M.; Codina-Martinez, H.; Tomas-Zapico, C.; Iglesias-Gutierrez, E.; Fernandez, A. F.; Fernandez-Garcia, B.
10.1101/2022.09.05.505110 — molecular biology — Posted on 2022-09-05
3643 Dual control of lysogeny and phage defense by a phosphorylation-based toxin/antitoxin system
Guo, Y.; Tang, K.; Sit, B.; Gu, J.; Chen, R.; Lin, J.; Lin, S.; Liu, X.; Wang, W.; Gao, X.; Nie, Z.; Liu, T.; Waldor, M. K.; Wang, X.
10.1101/2022.09.05.506569 — microbiology — Posted on 2022-09-05
3646 Substrate availability and not thermal-acclimation controls microbial temperature sensitivity response to long term warming
Domeignoz-Horta, L. A.; Pold, G.; Erb, H.; Sebag, D.; Verrecchia, E.; Northen, T.; Louie, K.; Eloe-Fadrosh, E.; Pennacchio, C.; Knorr, M. A.; Frey, S. D.; Melillo, J. M.; DeAngelis, K. M.
10.1101/2022.09.05.506639 — microbiology — Posted on 2022-09-05
3648 Tryptophol acetate and tyrosol acetate, metabolites secreted by a probiotic yeast, block cytokine storm
malka, o.; malishev, r.; bersudsky, m.; rajendran, m.; krishnamohan, m.; shaik, j.; chamovitz, d.; tikhonov, e.; sultan, e.; koren, o.; apte, r.; rosental, b.; voronov, e.; jelinek, r.
10.1101/2021.12.16.472991 — immunology — Posted on 2022-09-05
3649 Structural basis for membrane attack complex inhibition by CD59
Couves, E. C.; Gardner, S.; Voisin, T. B.; Bickel, J. K.; Stansfeld, P. J.; Tate, E. W.; Bubeck, D.
10.1101/2022.09.05.506672 — immunology — Posted on 2022-09-05
3650 Co-fluctuations of neural activity define intra-V1 networks related to perceptual organization
Valdes-Sosa, M. J.; Ontivero-Ortega, M.; Iglesias-Fuster, J.; Lage-Castellanos, A.; Galan-Garcia, L.; Valdes-Sosa, P. A.
10.1101/2022.08.22.504869 — neuroscience — Posted on 2022-09-05
3651 Mesenchymal-epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expression
Horny, K.; Sproll, C.; Peiffer, L.; Furtmann, F.; Gerhardt, P.; Gravemeyer, J.; Stoecklein, N. H.; Spassova, I.; Becker, J. C.
10.1101/2022.02.03.478962 — cancer biology — Posted on 2022-09-05
3652 Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
Meller, A.; Lotthammer, J. M.; Smith, L. G.; Novak, B.; Lee, L. A.; Kuhn, C. C.; Greenberg, L.; Leinwand, L. A.; Greenberg, M. J.; Bowman, G. R.
10.1101/2022.09.05.506254 — biophysics — Posted on 2022-09-05
3653 Uptake of aminoglycosides through outer membrane porins in Escherichia coli
Paul, E.; Ghai, I.; Hoeroempoeli, D.; Broetz-Oesterhelt, H.; Winterhalter, M.; Bafna, J. A.
10.1101/2022.09.05.506620 — biophysics — Posted on 2022-09-05
3655 mtHsp70 converts mitochondrial proteostasis distress into impaired protein import
Banerjee, R.; Trauschke, V.; Bertram, N.; Aretz, I.; Osman, C.; Lamb, D. C.; Mokranjac, D.
10.1101/2022.09.05.506649 — biochemistry — Posted on 2022-09-05
3656 Molecular insights into peptide agonist engagement with the PTH1 receptor
Cary, B. P.; Gerrard, E. J.; Belousoff, M. J.; Fletcher, M. M.; Jiang, Y.; Russell, I. C.; Piper, S. J.; Wootten, D.; Sexton, P. M.
10.1101/2022.09.04.506565 — biochemistry — Posted on 2022-09-05
3672 An automated BIDS-App for brain segmentation of human fetal functional MRI data
Nichols, E. S.; Correa, S.; Van Dyken, P.; Kai, J.; Kuehn, T. K.; de Ribaupierre, S.; Duerden, E. G.; Khan, A. R.
10.1101/2022.09.02.506391 — neuroscience — Posted on 2022-09-05
3674 Canonical and Replicable Multi-Scale Intrinsic Connectivity Networks in 100k+ Resting-State fMRI Datasets
Iraji, A.; Fu, Z.; Faghiri, A.; Duda, M.; Chen, J.; Rachakonda, S.; DeRamus, T. P.; Kochunov, P.; Adhikari, B. M.; Belger, A.; Ford, J.; Mathalon, D. H.; Pearlson, G. D.; Potkin, S. G.; Preda, A.; Turner, J. A.; Van Erp, T. G. M.; Bustillo, J. R.; Yang, K.; Ishizuka, K.; Sawa, A.; Hutchison, K.; Osuch, E. A.; Theberge, J.; Abbott, C.; Mueller, B. A.; Zhi, D.; Zhuo, C.; Liu, S.; Xu, Y.; Salman, M.; Liu, J.; Du, Y.; SUI, J.; Adali, T.; Calhoun, V.
10.1101/2022.09.03.506487 — neuroscience — Posted on 2022-09-05
3677 The UIP honeycomb airway cells are the site of mucin biogenesis with deranged cilia
Herrera, J. A.; Dingle, L. A.; Montero, M. A.; Rajamiyer, V.; Blaikley, J.; Granato, F.; Pearson, S.; Lawless, C.; Thornton, D. J.
10.1101/2022.09.03.506451 — pathology — Posted on 2022-09-05
3678 Tumor removal limits prostate cancer cell dissemination in bone cortex and osteoblasts induce cancer cell dormancy
Liu, R.; Su, S.; Liu, K.; Xing, J.; Stangis, M.; Jacho, D. P.; Yildirim-Ayan, E. D.; Yu, H.; Chen, B.; Li, X.
10.1101/2022.09.02.506436 — cancer biology — Posted on 2022-09-05
3679 Establishment and characterization of a tumoroid biobank derived from dog patients' mammary tumors for translational research
Raffo-Romero, A.; Aboulouard, S.; Bouchaert, E.; Rybicka, A.; Tierny, D.; Hajjaji, N.; Fournier, I.; Salzet, M.; Duhamel, M.
10.1101/2022.09.04.506533 — cancer biology — Posted on 2022-09-05
3680 Gene Expression Profiles Reveal Potential Targets for Breast Cancer Diagnosis and Treatment
Nasirpour, M. H.; Sabery Anvar, M.; Nasirpour, A.; Salimi, M.; Sepahyr, S.; Minuchehr, Z.
10.1101/2022.09.03.504469 — cancer biology — Posted on 2022-09-05
3681 Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source: Turkish DeLight
Atalay, N.; Akcan, E. K.; Gul, M.; Ayan, E.; Destan, E.; Ertem, F. B.; Tokay, N.; Cakilkaya, B.; Nergiz, Z.; Karakadioglu, G.; Kepceoglu, A.; Yapici, I.; Tosun, B.; Baldir, N.; Yildirim, G.; Johnson, J. A.; Guven, O.; Shafiei, A.; Arslan, N. E.; Yilmaz, M.; Kulakman, C.; Paydos, S. S.; Cinal, Z. S.; Sabanoglu, K.; Pazarceviren, A.; Yilmaz, A.; Canbay, B.; Asci, B.; Kartal, E.; Tavli, S.; Caliseki, M.; Goc, G.; Mermer, A.; Yesilay, G.; Altuntas, S.; Tateishi, H.; Otsuka, M.; Fujita, M.; Tekin, S.; Ciftci, H.; Durdagi, S.; Dinler Doganay, G.; Karaca, E.; Kaplan Turkoz, B.; Kabasakal, B. V.; Kati
10.1101/2022.09.03.506456 — biophysics — Posted on 2022-09-05
3684 Characterization of magnetic nanoparticles from the shells of freshwater mussel L fortunei and marine P perna mussels
Valadao Cardoso, A.; Carvalho e Souza, C.; Dantas, M. S.; Machado, C. S.; Fraga Freitas, E. T.; Krohling, A. C.; do Rosario, V. A. M.; Dias Heinene, L. G.
10.1101/2022.09.04.506556 — bioengineering — Posted on 2022-09-05
3689 Jack of all trades: genome assembly of Wild Jack and comparative genomics of Artocarpus
Patil, A. B.; Vajja, S. S.; Raghavendra, S.; Satish, B. N.; Kushalappa, C. G.; Vijay, N.
10.1101/2022.09.02.506353 — genomics — Posted on 2022-09-05
3691 Gene interaction perturbation network deciphers a high-resolution taxonomy in colorectal cancer
Liu, Z.; Weng, S.; Dang, Q.; Xu, H.; Ren, Y.; Guo, C.; Xing, Z.; Sun, Z.; Han, X.
10.1101/2022.09.02.506442 — genetics — Posted on 2022-09-05
3694 Risk factors and spatiotemporal analysis of classical swine fever in Ecuador
Acosta, A.; Dietze, K.; Baquero, O. S.; Vizzotto Osowski, G.; Imbacuan, C.; Burbano, A.; Ferreira, F.; Depner, K.
10.1101/2022.09.02.506027 — ecology — Posted on 2022-09-05
3695 Predicting predator-prey interactions in terrestrial endotherms using random forest
Llewelyn, J. S.; Strona, G.; Dickman, C. R.; Greenville, A.; Wardle, G.; Lee, M. S. Y.; Doherty, S.; Shabani, F.; Saltre, F.; Bradshaw, C. J. A.
10.1101/2022.09.02.506446 — ecology — Posted on 2022-09-05
3696 Rgs1 is a regulator of effector gene expression during plant infection by the rice blast fungus Magnaporthe oryzae
Talbot, N. J.; Tang, B.; Yan, X.; Ryder, L. S.; Cruz-Mireles, N.; Soanes, D. M.; Molinari, C.; Foster, A. J.
10.1101/2022.09.04.506535 — molecular biology — Posted on 2022-09-05
3697 Formulating a TMEM176B blocker in nanoparticles uncouples its paradoxical roles in innate and adaptive antitumoral immunity.
Victoria, S.; Castro, A.; Pittini, A.; Olivera, D.; Russo, S.; Cebrian, I.; Mombru, A. W.; Osinaga, E.; Pardo, H.; Segovia, M.; Hill, M.
10.1101/2022.09.02.506404 — immunology — Posted on 2022-09-05
3704 Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response
Arora, R.; Cao, C.; Kumar, M.; Sinha, S.; Chanda, A.; McNeil, R.; Samuel, D.; Arora, R. K.; Matthew, T. W.; Chandarana, S.; Hart, R.; Dort, J. C.; Biernaskie, J.; Neri, P.; Hyrcza, M. D.; Bose, P.
10.1101/2022.09.04.505581 — cancer biology — Posted on 2022-09-05
3705 Utility of stromal lymphocytes in diagnosis and predicting upgrade of B3 breast lesions from core biopsies
Kader, T.; Hendry, S.; Provenzano, E.; Jayawardana, M. W.; Pang, J.-M.; Elder, K.; Byrne, D. J.; Tjoeka, L.; Frazer, H. M.; House, E.; Jayasinghe, S.; Keane, H.; Murugasu, A.; Rajan, N.; Miligy, I. M.; Green, A. R.; Rakha, E. A.; Fox, S.; Mann, G. B.; Campbell, I. G.; Gorringe, K. L.
10.1101/2022.09.02.506444 — cancer biology — Posted on 2022-09-05
3709 Tyramine and its AmTYR1 receptor modulate attention in honey bees (Apis mellifera)
Latshaw, J. S.; Mazade, R. E.; Petersen, M.; Mustard, J. A.; Sinakevitch, I.; Wissler, L.; Guo, X.; Cook, C. N.; Lei, H.; Gadau, J.; Smith, B. H.
10.1101/2022.09.02.506392 — animal behavior and cognition — Posted on 2022-09-05
3711 Trade-offs constrain adaptive pathways to T6 survival
MacGillivray, K. A.; Ng, S. L.; Wiesenfeld, S.; Guest, R. L.; Jubery, T.; Silhavy, T. J.; Ratcliff, W. C.; Hammer, B. K.
10.1101/2022.09.02.506412 — evolutionary biology — Posted on 2022-09-05
3715 Ecology and age, but not genetic ancestry, predict fetal loss in a wild baboon hybrid zone
Fogel, A. S.; Oduor, P. O.; Nyongesa, A. W.; Kimwele, C. N.; Alberts, S. C.; Archie, E. A.; Tung, J.
10.1101/2022.09.03.505836 — evolutionary biology — Posted on 2022-09-05
3716 Tracking canopy gap dynamics across four sites in the Brazilian Amazon
Gorgens, E. B.; Keller, M.; Jackwon, T. D.; Marra, D. M.; Reis, C. R.; Almeida, D. R. A.; Coomes, D.; Ometto, J. P.
10.1101/2022.09.03.506473 — ecology — Posted on 2022-09-05
3717 Spatial variation in red deer density in relation to forest disturbance and ungulate management in a transboundary forest ecosystem
Tourani, M.; Franke, F.; Heurich, M.; Henrich, M.; Peterka, T.; Ebert, C.; Oeser, J.; Edelhoff, H.; Milleret, C.; Dupont, P.; Bischof, R.; Peters, W.
10.1101/2022.09.04.506509 — ecology — Posted on 2022-09-05
3718 Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques
Rosenke, K.; Lewis, M.; Feldmann, F.; Bohrnsen, E.; Schwarz, B.; Okumura, A.; Bohler, W. F.; Callison, J.; Shaia, C.; Bosio, C.; Lovaglio, J.; Saturday, G.; Jarvis, M.; Feldmann, H.
10.1101/2022.09.03.506479 — microbiology — Posted on 2022-09-05
3719 Delayed SARS-CoV-2 Spread and Olfactory Cell Lineage Impairment in Close-Contact Infection Syrian Hamster Models
Ueha, R.; Ito, T.; Ueha, S.; Furukawa, R.; Kitabatake, M.; Ouji-Sageshima, N.; Uranaka, T.; Tanaka, H.; Nishijima, H.; Kondo, K.; Yamasoba, T.
10.1101/2022.09.03.506499 — microbiology — Posted on 2022-09-05
3720 ApoE4 causes severe COVID-19 outcomes via downregulation of ACE2
Chen, F.; Chen, Y.; Ke, Q.; Wang, Y.; Chen, X.; Peng, X.; Cai, Y.; Li, S.; Sun, Y.; Ji, Y.; Jiang, Y.; Wu, W.; Wang, Y.; Cui, L.
10.1101/2022.09.04.506474 — neuroscience — Posted on 2022-09-05
3723 High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation
Laine, R. F.; Heil, H. S.; Coelho, S.; Nixon-Abell, J.; Jimenez, A.; Galgani, T.; Stubb, A.; Follain, G.; Goyette, J.; Webster, S.; Culley, S.; Jacquemet, G.; Hajj, B.; Leterrier, C.; Henriques, R.
10.1101/2022.04.07.487490 — biophysics — Posted on 2022-09-05
3724 Differentiation signals from glia are fine-tuned to set neuronal numbers during development
Prasad, A. R.; Lago-Baldaia, I.; Bostock, M. P.; Housseini, Z.; Fernandes, V. M.
10.1101/2021.12.13.472383 — neuroscience — Posted on 2022-09-05
3726 Light activation of Orange Carotenoid Protein reveals bicycle-pedal single-bond isomerization
Chukhutsina, V.; Baxter, J.; Fadini, A.; Morgan, R. M.; Pope, M.; Maghlaoui, K.; Orr, C.; Wagner, A.; van Thor, J.
10.1101/2022.01.17.475858 — biophysics — Posted on 2022-09-05
3728 Masculinization of the X-chromosome in aphid soma and gonads
Jaquiery, J.; Simon, J.-C.; Robin, S.; Richard, G.; Peccoud, J.; Boulain, H.; Legeai, F.; Tanguy, S.; Prunier-Leterme, N.; Letrionnaire, G.
10.1101/2021.08.13.453080 — evolutionary biology — Posted on 2022-09-05
3729 Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans
Kumar, A. V.; Mills, J.; Parker, W. M.; Leitao, J.; Rodriguez, D. I.; Ng, C.; Patel, R.; Aguilera, J. L.; Johnson, J. R.; Wong, S. Q.; Lapierre, L. R.
10.1101/2021.04.22.440991 — cell biology — Posted on 2022-09-05
3730 IL-22BP production is heterogeneously distributed in Crohn's disease
Fantou, A.; Lagrue, E.; Laurent, T.; Delbos, L.; Blandin, S.; Jarry, A.; Beriou, G.; Braudeau, C.; Salabert-Le Guen, N.; Marin, E.; Moreau, A.; Podevin, J.; Bourreille, A.; Josien, R.; Martin, J. C.
10.1101/2021.04.07.438837 — immunology — Posted on 2022-09-05
3732 MTORC2 is a physiological hydrophobic motif kinase of S6 Kinase 1.
Majeed, S. T.; Majeed, R.; Malik, A.; Zargar, M. A.; Andrabi, K. I.
10.1101/2021.08.17.456612 — molecular biology — Posted on 2022-09-05
3735 A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis
Mohammed, J.; Arora, N.; Matthews, H.; Hansen, K.; Bader, M.; Shaffer, J. R.; Weinberg, S. M.; Swigut, T.; Peter Claes, P.; Selleri, L.; Wysocka, J.
10.1101/2022.09.05.506587 — developmental biology — Posted on 2022-09-05
3736 Automatic Sample Segmentation & Detection of Parkinson's Disease Using Synthetic Staining & Deep Learning
Pearce, B. M.; Coetzee, P. L.; Rowland, D.; Linfoot, S.; Dexter, D. T.; Gveric, D. O.; Gentleman, S.
10.1101/2022.08.30.505459 — pathology — Posted on 2022-09-05
3747 Development of the alpha rhythm is linked to visual white matter pathways and visual detection performance
Caffarra, S.; Kanopka, K.; Kruper, J.; Richie-Halford, A.; Roy, E.; Rokem, A.; Yeatman, J. D.
10.1101/2022.09.03.506461 — neuroscience — Posted on 2022-09-04
3749 NPAS4 supports drug-cue associations and relapse-like behavior through regulation of the cell type-specific activation balance in the nucleus accumbens
Hughes, B. W.; Tsvetkov, E.; Siemsen, B. M.; Snyder, K. K.; Akiki, R. M.; Wood, D. J.; Penrod, R. D.; Scofield, M. D.; Berto, S.; Taniguchi, M.; Cowan, C. W.
10.1101/2022.09.04.506434 — neuroscience — Posted on 2022-09-05
3750 How inhibitory and excitatory inputs gate output of the inferior olive
Loyola, S.; Hoogland, T. M.; Negrello, M.; Hoedemaker, H.; Romano, V. E.; De Zeeuw, C. I.
10.1101/2022.09.04.506491 — neuroscience — Posted on 2022-09-05
3753 G-quadruplex landscape and its regulation revealed by a new antibody capture method
Datta, S.; Patel, M.; Sathyaseelan, C.; Patel, D.; Rathinavelan, T.; Singh, U.
10.1101/2022.09.03.506459 — genomics — Posted on 2022-09-04
3755 Discovery of thyrocyte heterogeneity reveals an essential role of Notch signaling in thyroid function and mammalian homeostasis
Mosteiro, L.; Nguyen, T. T. T.; Hankeova, S.; Reichelt, M.; Vandriel, S. M.; Lai, Z.; Choudhury, F. K.; Sangaraju, D.; Kamath, B. M.; Scherl, A.; Piskol, R.; Siebel, C. W.
10.1101/2022.09.02.506441 — cell biology — Posted on 2022-09-04
3757 Cortical Circuit Mechanisms of Multimodal Temporal Pattern Discrimination
Post, S.; Mol, W.; Abu-Wishah, O.; Ali, S.; Rahmatullah, N.; Goel, A.
10.1101/2022.08.31.506133 — neuroscience — Posted on 2022-09-04
3760 Understanding emergence of antimycobacterial dose dependent resistance.
Kloprogge, F.; Ortiz Canseco, J.; Phee, L.; Sadouki, Z.; Kipper, K.; Witney, A. A.; Stoker, N.; McHugh, T. D.
10.1101/2022.09.02.506358 — pharmacology and toxicology — Posted on 2022-09-04
3761 PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling
Hay, J.; Tarafdar, A.; Holroyd, A.; Moka, H. A.; Dunn, K. M.; Alshayeb, A.; Lloyd, B. H.; Cassels, J.; Malik, N.; Khan, A. F.; Sou, I.; Lees, J.; Almuhanna, H. N.; Kalakonda, N.; Slupsky, J. R.; Michie, A. M.
10.1101/2022.09.04.506520 — cancer biology — Posted on 2022-09-04
3762 Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells
Amoozgar, Z.; Ren, J.; Wang, N.; Andersson, P.; Ferraro, G.; Rajan, S.; Lei, P.; Subudhi, S.; Kawaguchi, K.; Tay, R. E.; Gomes Dos Santos, I. L.; Huang, P.; Kim, H.-J.; Fukumura, D.; Jain, R.
10.1101/2022.09.03.506476 — cancer biology — Posted on 2022-09-04
3763 Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells
YANG, C.; Wierbilowicz, K.; Abianeh, N.; Abbas, T.; Ratan, A.; Wotton, D.; Paschal, B. M.
10.1101/2022.09.02.506406 — cancer biology — Posted on 2022-09-04
3770 Evaluating microbial contaminations of alternative heating oils
Surger, M. J.; Mayer, K.; Shivaram, K.; Stibany, F.; Plum, W.; Schaeffer, A.; Eiden, S.; Blank, L. M.
10.1101/2022.09.04.506525 — microbiology — Posted on 2022-09-04
3772 Neuroligin-3 in Dopaminergic Circuits Promotes Behavioral and Neurobiological Adaptations to Chronic Morphine Exposure
Brandner, D. D.; Retzlaff, C. L.; Kocharian, A.; Stieve, B. J.; Mashal, M. A.; Mermelstein, P. G.; Rothwell, P. E.
10.1101/2022.03.14.484267 — neuroscience — Posted on 2022-09-04
3773 LARP1 regulates metabolism and mTORC1 activity in cancer
Chettle, J.; Dedeic, Z.; Fischer, R.; Vendrell, I.; Campo, L.; Easton, A.; Browne, M.; Morris, J.; Schwenzer, H.; Lascaux, P.; Gijsbers, R.; Pires, E.; Royston, D. J.; Ferguson, D. J. P.; Coosemans, A.; Kessler, B.; McCullagh, J.; Ahmed, A. A.; Ramadan, K.; Bushell, M.; Harris, A. L.; Goding, C. R.; Blagden, S. P.
10.1101/2022.09.04.506559 — cancer biology — Posted on 2022-09-04
3774 Structural Reorganization and Relaxation Dynamics of Axially Stressed Chromosomes
Ruben, B. S.; Brahmachari, S.; Contessoto, V. G.; Cheng, R. R.; Oliveira Junior, A. B.; Di Pierro, M.; Onuchic, J. N.
10.1101/2022.09.03.506488 — biophysics — Posted on 2022-09-04
3776 RosettaDDGPrediction for high-throughput mutational scans: from stability to binding
Valentina, S.; Otamendi Laspiur, A.; Degn, K.; Arnaudi, M.; Utichi, M.; Beltrame, L.; De Menezes, D.; Orlandi, M.; Rigina, O.; Sackett, P. W.; Wadt, K.; Schmiegelow, K.; Papaleo, E.
10.1101/2022.09.02.506350 — bioinformatics — Posted on 2022-09-04
3777 A Beefy-R culture medium: replacing albumin with rapeseed protein isolates
Stout, A. J.; Rittenberg, M. L.; Shub, M.; Saad, M. K.; Mirliani, A. B.; Kaplan, D. L.
10.1101/2022.09.02.506409 — bioengineering — Posted on 2022-09-04
3779 RTEL-1 and DNA polymerase theta promote subtelomeric DNA synthesis and telomere fusion in C. elegans
Ahmed, S.; Lister-Shimauchi, E.; Brady, M.; Frenk, S.; Harris, B.; Ortiz, A.-M. L.; Memili, A.; Nguyen, M.; Boulton, S.
10.1101/2022.09.04.506531 — genetics — Posted on 2022-09-04
3783 Pseudokinase HPO-11 inhibits nonsense-mediated decay to ensure genome stability in C. elegans
Zhao, Q.; Gromoff, E. D. v.; Yang, W.; Schwarz, J.; Schulze, E.; Warscheid, B.; Baumeister, R.; Qi, W.
10.1101/2022.09.04.506508 — molecular biology — Posted on 2022-09-04
3784 Linking mesozooplankton and SAR11 bacteria in Oxygen Deficient Zones and the open ocean
Fuchsman, C. A.; Hays, M. D.; Huanca-Valenzuela, P.; Gregory, B. P.; Plough, L. V.; Duffy, M. E.; Keil, R. G.; Peng, X.
10.1101/2022.09.04.506529 — microbiology — Posted on 2022-09-04
3785 Enhanced Effector Activity of Mediator Kinase Module Deficient CAR-T Cells
Freitas, K. A.; Belk, J. A.; Sotillo, E.; Daniel, B.; Sandor, K.; Klysz, D.; Duong, V. T.; Burdsall, K. A.; Xu, P.; Malipatlolla, M.; Donovan, M. G.; Weber, E. W.; Majzner, R. G.; Chang, H. Y.; Espinosa, J. M.; Satpathy, A. T.; Mackall, C. L.
10.1101/2022.09.02.506235 — immunology — Posted on 2022-09-04
3789 Microphysiological vascular malformation model reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation.
Aw, W. Y.; Cho, C.; Wang, H.; Cooper, A. H.; Doherty, E. L.; Rocco, D.; Huang, S. A.; Kubik, S.; Whitworth, C. P.; Armstrong, R.; Hickey, A. J.; Griffith, B.; Kutys, M. L.; Blatt, J.; Polacheck, W. J.
10.1101/2022.09.03.506415 — bioengineering — Posted on 2022-09-04
3791 Whole-genome duplication reshaped adaptive evolution in a relict plant species, Cyclocarya paliurus
Yinquan, Q.; Xulan, S.; Ziyan, Z.; Yanhao, Y.; Guoliang, B.; Wenling, W.; Li, L.; Li, T.; Shengcheng, Z.; Qian, W.; Dejin, X.; Xuequn, C.; Zhenyang, L.; Yibin, W.; Jian, Q.; Wanxia, Y.; Caowen, S.; Xiangxiang, F.; Xingtan, Z.; Shengzuo, F.
10.1101/2022.09.04.506500 — genetics — Posted on 2022-09-04
3793 Early detection of late blight in potato by whole-plant redox imaging
Hipsch, M.; Michael, Y.; Lampl, N.; Sapir, O.; Cohen, Y.; Helman, D.; Rosenwasser, S.
10.1101/2022.09.04.506513 — plant biology — Posted on 2022-09-04
3799 Ecological corridors homogenize plant root endospheric mycobiota
Hu, J.; Vandenkoornhuyse, P.; Khalfallah, F.; Causse-Vedrines, R.; Mony, C.
10.1101/2022.09.02.506380 — ecology — Posted on 2022-09-04
3802 Compartmentation of putrescine synthesis in plants
Joshi, K.; Ahmed, S.; Ge, L.; Phuntumart, V.; Kalinoski, A.; Morris, P. F.
10.1101/2022.09.03.506421 — plant biology — Posted on 2022-09-04
3803 Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2
Haji, S.; Ito, T.; Guenther, C.; Nakano, M.; Shimizu, T.; Mori, D.; Chiba, Y.; Tanaka, M.; Mishra, S. K.; Willment, J. A.; Brown, G. D.; Nagae, M.; Yamasaki, S.
10.1101/2022.09.02.506356 — immunology — Posted on 2022-09-04
3804 Developmental Basis of SHH Medulloblastoma Heterogeneity
Gold, M. P.; Ong, W.; Masteller, A. M.; Galindo, J. A.; Park, N. R.; Saurez, R. A.; Vladoiu, M. C.; Donovan, L. K.; Walker, A. D.; Benetatos, J.; Garzia, L.; Wechsler-Reya, R. J.; Mesirov, J. P.; Korshunov, A.; Pomeroy, S. L.; Davidson, S. M.; Cotter, J. A.; Taylor, M. D.; Fraenkel, E.
10.1101/2022.09.02.506110 — cancer biology — Posted on 2022-09-04
3807 Regulation of neuropathic pain by microglial Orai1 channels
Tsujikawa, S.; DeMeulenaere, K. E.; Ceneno, M. V.; Ghazisaeidi, S.; Martin, M. E.; Tapies, M. R.; Maneshi, M. M.; Yamashita, M.; Stauderman, K. A.; Apkarian, A. V.; Salter, M. W.; Prakriya, M.
10.1101/2022.09.02.506250 — neuroscience — Posted on 2022-09-04
3808 Arc ubiquitination regulates endoplasmic reticulum-mediated Ca2+ release and CaMKII signaling
Ghane, M. A.; Allen, Z. D.; Miller, C. L.; Dong, B.; Fang, N.; Yang, J. J.; Mabb, A. M.
10.1101/2022.09.02.506383 — neuroscience — Posted on 2022-09-04
3810 Tracking subject's strategies in behavioural choice experiments at trial resolution
Maggi, S.; Hock, R. M.; O'Neill, M.; Buckley, M. J.; Moran, P. M.; Bast, T.; Sami, M.; Humphries, M. D.
10.1101/2022.08.30.505807 — neuroscience — Posted on 2022-09-04
3811 Single-cell analysis of bovine muscle-derived cell types for cultured meat production
Messmer, T.; Dohmen, R. G.; Schaeken, L.; Melzener, L.; Hueber, R.; Godec, M.; Post, M. J.; Flack, J. E.
10.1101/2022.09.02.506369 — cell biology — Posted on 2022-09-04
3813 Transcriptome and chromatin accessibility landscapes across 25 distinct human brain regions expand the susceptibility gene set for neuropsychiatric disorders
Dong, P.; Bendl, J.; Misir, R.; Shao, Z.; Edelstien, J.; Davis, D. A.; Haroutunian, V.; Scott, W. K.; Acker, S.; Lawless, N.; Hoffman, G. E.; Fullard, J. F.; Roussos, P.
10.1101/2022.09.02.506419 — neuroscience — Posted on 2022-09-04
3815 Is evolutionary conservation a useful predictor for cancer long noncoding RNAs? Insights from the Cancer lncRNA Census 3
Vancura, A.; Gutierrez, A. H.; Hennig, T.; Pulido-Quetglas, C.; Slack, F.; Johnson, R.; Haefliger, S.
10.1101/2022.09.01.506261 — cancer biology — Posted on 2022-09-04
3816 Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation
Cutts, A. J.; Chowdhury, S.; Ratkay, L.; Eyers, M.; Young, C.; Namdari, R.; Cadieux, J.; Chahal, N.; Grimwood, M.; Zhang, Z.; Lin, S.; Tietjen, I.; Xie, Z.; Robinette, L.; Sojo, L.; Waldbrook, M.; Hayden, M. R.; Mansour, T.; Pimstone, S.; Goldberg, Y. P.; Webb, M.; Cohen, C. J.
10.1101/2022.09.01.506269 — pharmacology and toxicology — Posted on 2022-09-04
3818 Tailored machine learning models for functional RNA detection in genome-wide screens
Klapproth, C.; Zoeztsche, S.; Kuehnl, F.; Findeiss, S.; Fallmann, J.; Stadler, P. F.
10.1101/2022.09.01.506220 — bioinformatics — Posted on 2022-09-04
3819 Size-tunable ICG-based contrast agent platform for targeted near-infrared photoacoustic imaging
Singh, S.; Giammanco, G.; Hu, C.-H.; Bush, J.; Cordova, L. S.; Lawrence, D. J.; Moran, J. L.; Chitnis, P. V.; Veneziano, R.
10.1101/2022.09.01.506234 — bioengineering — Posted on 2022-09-04
3820 Length-limitation of astral microtubules orients cell divisions in intestinal crypts
Saleh, J.; Fardin, M.-A.; Frenoy, O.; Soleilhac, M.; Gaston, C.; Cui, H.; Dang, T.; Gaudin, N.; Vincent, A.; MINC, N.; Delacour, D.
10.1101/2022.09.02.506333 — developmental biology — Posted on 2022-09-04
3821 Chemoenzymatic Measurement of Cell-surface Glycan in Single-cell Multiomics: LacNAc as an Example
Yu, W.; Zhao, X.; Jalloh, A. S.; Zhao, Y.; Dinner, B.; Yang, Y.; Ouyang, S.; Li, Y.; Tian, T.; Zhao, Z.; Yang, R.; Chen, M.; Lauvau, G.; Guo, Z.; Wu, P.; Li, J. P.
10.1101/2022.09.01.506123 — immunology — Posted on 2022-09-04
3823 Altered tau in rTg4510 mice after a single interfaced CHIMERA traumatic brain injury
Cheng, W. H.; Cheung, H.; Kang, A.; Fan, J.; Cooper, J.; Anwer, M.; Barron, C.; Wilkinson, A.; Hu, G.; Yue, J.; Cripton, P. A.; Vocadlo, D.; Wellington, C. L.
10.1101/2022.09.01.506145 — neuroscience — Posted on 2022-09-04
3825 Phosphate starvation response precedes abscisic acid response in response to mild drought in plants
Nagatoshi, Y.; Ikazaki, K.; Mizuno, N.; Kobayashi, Y.; Fujii, K.; Ogiso-Tanaka, E.; Ishimoto, M.; Yasui, Y.; Oya, T.; Fujita, Y.
10.1101/2021.07.28.453724 — plant biology — Posted on 2022-09-04
3827 A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer
Inglebert, M.; Dettwiler, M.; Hahn, K.; Letko, A.; Droegemueller, C.; Doench, J. G.; Brown, A.; Memari, Y.; Davies, H.; Degasperi, A.; Nik-Zainal, S.; Rottenberg, S.
10.1101/2022.09.02.505845 — cancer biology — Posted on 2022-09-03
3833 Gas modulating microcapsules for spatiotemporal control of hypoxia
molley, t. G.; Jiang, S.; Kopecky, C.; Ranaweera, C. D.; Jalandhra, G. K.; Rnjak-Kovacina, J.; Kilian, K. A.
10.1101/2022.09.02.506302 — bioengineering — Posted on 2022-09-04
3834 Contrasting genomic evolution between domesticated and wild Kluyveromyces lactis yeast populations
Friedrich, A.; Gounot, J.-S.; Tsouris, A.; Bleykasten, C.; Freel, K.; Caradec, C.; Schacherer, J.
10.1101/2022.09.02.506316 — genomics — Posted on 2022-09-03
3835 Epistatic effects between amino acid insertions and substitutions mediate toxin-resistance of vertebrate Na+,K+-ATPases
Mohammadi, S.; Özdemir, H. I.; Ozbek, P.; Sumbul, F.; Stiller, J.; Deng, Y.; Crawford, A. J.; Rowland, H. M.; Storz, J. F.; Andolfatto, P.; Dobler, S.
10.1101/2022.09.01.506169 — evolutionary biology — Posted on 2022-09-04
3836 Identifying the potential for sustainable human wildlife coexistence by integrating willingness to coexist with habitat suitability models
Vogel, S. M.; Vasudev, D.; Ogutu, J. O.; Taek, P.; Berti, E.; Goswami, V. R.; Kaelo, M.; Buitenwerf, R.; Munk, M.; Li, W.; Wall, J.; Gelete, D. C.; Amoke, I.; Odingo, A.; Svenning, J.-C.
10.1101/2022.09.02.506181 — ecology — Posted on 2022-09-03
3839 Quantitative proteomics and lipidomics of TFG-deficient B cells provide insights into mechanisms of autophagic flux and plasma cell biology
Steinmetz, T. D.; Reimann, L.; Schulz, S. R.; Urbanczyk, S.; Thomas, J.; Himmelreich, A.-K.; Golombek, F.; Castiglione, K.; Brodesser, S.; Warscheid, B.; Mielenz, D.
10.1101/2022.09.01.506221 — immunology — Posted on 2022-09-03
3840 WDFY4 deficiency in NOD mice abrogates autoimmune diabetes and insulitis
Ferris, S. T.; Chen, J.; Ohara, R. A.; Wu, R.; Kim, S.; Liu, T.; Murphy, T.; Murphy, K. M.
10.1101/2022.09.02.506326 — immunology — Posted on 2022-09-03
3848 Novel Laser Capture Microdissection-Proteomic Analysis Identifies Spatially Distinct Extracellular Matrix Signatures in the Core and Infiltrating Edge of Human Glioblastoma.
Pedley, R.; Prescott, D. T.; Appleton, E.; Dingle, L.; Minshull, J.; D'Urso, P. I.; Djoukhadar, I.; Gilmore, A. P.; Roncaroli, F.; Swift, J.
10.1101/2022.09.01.506199 — cancer biology — Posted on 2022-09-03
3854 SpaCeNet: Spatial Cellular Networks from omics data
Lück, N.; Lohmayer, R.; Solbrig, S.; Schrod, S.; Wipfler, T.; Shutta, K. H.; Guebila, M. B.; Schäfer, A.; Beissbarth, T.; Zacharias, H. U.; Oefner, P. J.; Quackenbush, J.; Altenbuchinger, M.
10.1101/2022.09.01.506219 — bioinformatics — Posted on 2022-09-03
3858 Recovering birds and mammals across Europe continue to be negatively impacted by threats but benefit from conservation measures
Gray, C.; McRae, L.; Deinet, S.; Ledger, S. E. H.; Benham, C.; Burfield, I.; Eaton, M.; Scott-Gatty, K.; Puleston, H.; Rutherford, C.; Staneva, A.; Schepers, F.; Freeman, R.
10.1101/2022.09.01.506271 — ecology — Posted on 2022-09-03
3859 Myelin plasticity in ventral tegmental area is required for opioid reward
Yalcin, B.; Pomrenze, M. B.; Malacon, K.; Chau, I. J.; Taylor, K. R.; Ni, L.; Contreras-Esquivel, D.; Malenka, R. C.; Monje, M.
10.1101/2022.09.01.506263 — neuroscience — Posted on 2022-09-03
3860 A Principal Odor Map Unifies Diverse Tasks in Human Olfactory Perception
Lee, B. K.; Mayhew, E. E.; Sanchez-Lengeling, B.; Wei, J. N.; Qian, W. W.; Little, K.; Andres, M.; Nguyen, B. B.; Moloy, T.; Parker, J. K.; Gerkin, R. C.; Mainland, J. D.; Wiltschko, A. B.
10.1101/2022.09.01.504602 — neuroscience — Posted on 2022-09-03
3861 Imaging through Windansee electrode arrays reveals a small fraction of local neurons following surface MUA
Thunemann, M.; Hossain, L.; Ness, T. V.; Rogers, N.; Lee, K.; Lee, S.-H.; Kılıc, K.; Oh, H.; Economo, M. N.; Gilja, V.; Einevoll, G.; Dayeh, S.; Devor, A.
10.1101/2022.09.01.506113 — neuroscience — Posted on 2022-09-03
3862 IL-10 inhibits STAT1-dependent macrophage accumulation during microbiota-induced colitis
Patik, I.; Redhu, N. S.; Eran, A.; Bao, B.; Nandy, A.; Tang, Y.; El Sayed, S.; Shen, Z.; Glickman, J.; Fox, J. G.; Snapper, S.; Horwitz, B. H.
10.1101/2022.09.01.505766 — immunology — Posted on 2022-09-03
3864 Two-Dimensional-Dwell-Time Analysis of Ion Channel Gating using High Performance Computing Clusters
Oikonomou, E.; Gruber, T.; Chandra, A. R.; Hoeller, S.; Alzheimer, C.; Wellein, G.; Huth, T.
10.1101/2022.09.01.506168 — physiology — Posted on 2022-09-03
3865 Intra-islet glucagon signalling regulates pulsatile insulin secretion and glucose homeostasis
Suba, K.; Patel, Y.; Alonso, A. M.; Roberts, A.; Hansen, B.; Norton, M.; Shrewsbury, J.; Kwok, R.; Kalogianni, V.; Chen, S.; Liu, X.; Rutter, G. A.; Jones, B.; Minnion, J.; Owen, B. M.; Distaso, W.; Drucker, D. J.; Tan, T. M.; Bloom, S. R.; Murphy, K.; Salem, V.
10.1101/2022.09.01.506223 — physiology — Posted on 2022-09-03
3868 Divergent microbial traits influence the transformation of living versus dead root inputs to soil carbon
Sokol, N.; Foley, M.; Blazewicz, S. J.; Battacharyya, A.; Estera-Molina, K.; Firestone, M. K.; Greenlon, A.; Hungate, B. A.; Kimbrel, J.; Liquet, J.; Lafler, M.; Marple, M.; Nico, P.; Slessarev, E.; Pett-Ridge, J.
10.1101/2022.09.02.506384 — ecology — Posted on 2022-09-03
3870 Motion of single molecular tethers reveals dynamic subdomains at ER-mitochondria contact sites
Obara, C. J.; Nixon-Abell, J.; Moore, A. S.; Riccio, F.; Hoffman, D. P.; Shtengel, G.; Xu, C. S.; Schaefer, K.; Pasolli, H. A.; Masson, J.-B.; Hess, H. F.; Calderon, C. P.; Blackstone, C.; Lippincott-Schwartz, J.
10.1101/2022.09.03.505525 — cell biology — Posted on 2022-09-03
3873 In silico conformational features of botulinum toxins A1 and E1 according to the intraluminal acidification
Cottone, G.; Chiodo, L.; Maragliano, L.; Popoff, M.-R.; Rasetti-Escargueil, C.; Lemichez, E.; Malliavin, T. E.
10.1101/2022.09.01.506163 — neuroscience — Posted on 2022-09-03
3874 Cortical Circuit Mechanisms of Multimodal Temporal Pattern Discrimination
Post, S.; Mol, W.; Abu-Wishah, O.; Ali, S.; Rahmatullah, N.; Goel, A.
10.1101/2022.08.31.506133 — neuroscience — Posted on 2022-09-03
3875 Outcome of Crash Course Training on Protein Structure Prediction with Artificial Intelligence
Balamurugan, D.; Dougherty, M.; Lubin, J.; Arias, P.; Chang, J.; Dalenberg, K.; Kholodovych, V.; Zelzion, E.; Khare, S.; von Oehsen, J. B.; Zwick, M. E.; Burley, S. K.
10.1101/2022.09.01.506222 — scientific communication and education — Posted on 2022-09-03
3881 A deep learning and digital archaeology approach for mosquito repellent discovery
Wei, J. N.; Vlot, M.; Sanchez-Lengeling, B.; Lee, B. K.; Berning, L.; Vos, M. W.; Henderson, R. W.; Qian, W. W.; Ando, D. M.; Groetsch, K. M.; Gerkin, R. C.; Wiltschko, A. B.; Dechering, K. J.
10.1101/2022.09.01.504601 — bioengineering — Posted on 2022-09-03
3886 Extensive cellular multitasking within Bacillus subtilis biofilms
Yannarell, S. M.; Beaudoin, E. S.; Talley, H. S.; Schoenborn, A. A.; Orr, G.; Anderton, C. R.; Chrisler, W. B.; Shank, E. A.
10.1101/2022.09.02.506450 — microbiology — Posted on 2022-09-03
3887 LRRK2-G2019S SYNERGIZES WITH AGEING AND LOW-GRADE INFLAMMATION TO PROMOTE GUT AND PERIPHERAL IMMUNE CELL ACTIVATION THAT PRECEDE NIGROSTRIATAL DEGENERATION
Giachino, C.; Tirolo, C.; Caniglia, S.; Serapide, M. F.; L'Episcopo, F.; Bertoli, F.; Giuliano, C.; Mearelli, M.; Jakobi, M.; Schneiderhan-Marra, N.; Deleidi, M.; Marchetti, B.
10.1101/2022.09.01.505977 — neuroscience — Posted on 2022-09-03
3888 TRPA1 analgesia is mediated by kappa opioid receptors
Semizoglou, E.; Gentry, C.; Vastani, N.; Stucky, C. L.; Andersson, D. A.; Bevan, S.
10.1101/2022.09.01.506151 — neuroscience — Posted on 2022-09-03
3889 Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2
Frangos, Z. J.; Wilson, K. A.; Aitken, H. M.; Cantwell Chater, R.; Vandenberg, R. J.; O'Mara, M. L.
10.1101/2022.08.31.506132 — neuroscience — Posted on 2022-09-03
3890 Endogenous tagging of Unc-13 reveals nanocluster reorganization at active zones during presynaptic homeostatic potentiation
Dannhäuser, S.; Mrestani, A.; Gundelach, F.; Pauli, M.; Komma, F.; Kollmannsberger, P.; Sauer, M.; Heckmann, M.; Paul, M.
10.1101/2022.08.31.506141 — neuroscience — Posted on 2022-09-03
3892 Identification of a novel HASPIN inhibitor and its synergism with the PLK1 inhibitor
Kwon, E.-J.; Mashelkar, K.; Seo, J.; Shin, Y.; Sung, K.; Jang, S. C.; Cheon, S. W.; Lee, H.; Han, B. W.; Jeong, L. S.; Cha, H.-J.
10.1101/2022.09.01.506282 — pharmacology and toxicology — Posted on 2022-09-03
3893 In vivo CRISPR screen defines Slc25a37 as an organ-specific regulator of antioxidant metabolism in metastasis
Cuadros, A. M.; Fernandez-Garcia, J.; Planque, M.; Altea-Manzano, P.; Schalley, T.; Vermeire, I.; Broekaert, D.; Wu, Q.; Van Brussel, T.; Leduc, S.; Maetens, M.; Nguyen, H.-L.; Van Baelen, K.; Darzi, N.; Floris, G.; Wildiers, H.; Desmedt, C.; Lambrechts, D.; Fendt, S.-M.
10.1101/2022.09.03.506468 — cancer biology — Posted on 2022-09-03
3894 Treatment-mediated selection of lethal prostate cancer clones defined by copy number architectures
Hasan, A. M. M.; Cremaschi, P.; Wetterskog, D.; Jayaram, A.; Wong, S. Q.; Williams, S.; Pasam, A.; Trigos, A.; Trujillo, B.; Grist, E.; Friedrich, S.; Vainauskas, O.; Parry, M.; Ismail, M.; Devlies, W.; Wingate, A.; Lise, S.; Sandhu, S.; Attard, G.
10.1101/2022.09.01.506183 — cancer biology — Posted on 2022-09-03
3896 Revisiting the burden borne by fumarase: enzymatic hydration of an olefin
Bellur, A.; Das, S.; Jayaraman, V.; Behera, S.; Suryavanshi, A.; Balasubramanian, S.; Balaram, P.; Jindal, G.; Balaram, H.
10.1101/2022.09.03.506457 — biochemistry — Posted on 2022-09-03
3899 Neighbourhood effect of weeds on wheat root endospheric mycobiota
Hu, J.; Ricono, C.; Fournier, P.; Mondy, S.; Vandenkoornhuyse, P.; Mony, C.
10.1101/2022.09.02.506399 — ecology — Posted on 2022-09-03
3901 High resolution photocatalytic mapping of SARS-CoV-2 Spike protein-host cell membrane interactions
Datta, S.; Tavares, A. H.; Reyes-Robles, T.; Ryu, K. A.; Khan, N.; Bechtel, T. J.; Bertoch, J. M.; White, C. H.; Hazuda, D. J.; Vora, K. A.; Hett, E. C.; Fadeyi, O. O.; Oslund, R. C.; Saeed, M.; Emili, A.
10.1101/2022.09.02.506438 — biochemistry — Posted on 2022-09-03
3902 The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins
Miller, A. N.; Houlihan, P. R.; Matamala, E.; Cabezas-Bratesco, D.; Lee, G. Y.; Cristofori-Armstrong, B.; Dilan, T. L.; Sanchez-Martinez, S.; Matthies, D.; Yan, R.; Yu, Z.; Ren, D.; Brauchi, S. E.; Clapham, D. E.
10.1101/2022.09.02.506428 — biophysics — Posted on 2022-09-03
3908 More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway.
Hodgins, J.; Abou-Hamad, J.; Hagerman, A.; Yakubovich, E.; Tanese De Souza, C.; Marotel, M.; Buchler, A.; Fadel, S.; Park, M.; Fong-McMaster, C.; Crupi, M. J. F.; Bell, J. C.; Harper, M.-E.; Rotstein, B.; Auer, R.; Vanderhyden, B.; Sabourin, L.; Bourgeois-Daigneault, M.-C.; Cook, D.; Ardolino, M.
10.1101/2022.08.31.506095 — cancer biology — Posted on 2022-09-03
3911 From sequence to function through structure: deep learning for protein design
Ferruz, N.; Heinzinger, M.; Akdel, M.; Goncearenco, A.; Naef, L.; Dallago, C.
10.1101/2022.08.31.505981 — bioinformatics — Posted on 2022-09-03
3916 Rapid Identity and Quantity CQA Test for Multivalent mRNA Drug Product Formulations
Gao, R. Y.; Riley, C. M.; Toth, E.; Blair, R. H.; Gerold, M. N.; McCormick, C.; Taylor, A. W.; Hu, T.; Rowlen, K. L.; Dawson, E. D.
10.1101/2022.08.31.506088 — bioengineering — Posted on 2022-09-03
3918 Associations of Minor Histocompatibility Antigens with Clinical Outcomes Following Allogeneic Hematopoietic Cell Transplantation
Jadi, O.; Tang, H.; Olsen, K.; Vensko, S.; Zhu, Q.; Wang, Y.; Haiman, C. A.; Pooler, L.; Sheng, X.; Brock, G.; Webb, A.; Pasquini, M. C.; McCarthy, P. L.; Spellman, S. R.; Hahn, T.; Vincent, B. G.; Armistead, P.; Sucheston-Campbell, L. E.
10.1101/2022.08.31.506092 — genetics — Posted on 2022-09-03
3919 CIRKO: A chemical-induced reversible gene knockout system for studying gene function in situ
Shi, H.; Jin, Q.; Chen, F.; Ouyang, Z.; Gou, S.; Liu, X.; Li, L.; Mu, S.; Lai, C.; Zhang, Q.; Ye, Y.; Wang, K.; Lai, L.
10.1101/2022.08.31.506064 — genetics — Posted on 2022-09-03
3923 Decoding spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin
Li, X.; Andrusivova, Z.; Czarnewski, P.; Langseth, C. M.; Andersson, A.; Liu, Y.; Gyllborg, D.; Braun, E.; Larsson, L.; Hu, L.; Alekseenko, Z.; Lee, H.; Avenel, C.; Kallner, H. K.; Akesson, E.; Adameyko, I.; Nilsson, M.; Linnarsson, S.; Lundeberg, J.; Sundstrom, E.
10.1101/2022.08.31.505986 — developmental biology — Posted on 2022-09-03
3924 Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis
Chao, Y.; Xiang, Y.; Xiao, J.; Zhang, S.; Zheng, W.; Wan, X.; LI, Z.; Gao, M.; Wang, G.; Chen, Z.; Ebrahimkhani, M.; Yang, C.; Wu, A. R.; Liu, P.; Huang, Y.; Sugimura, R.
10.1101/2022.09.02.505700 — developmental biology — Posted on 2022-09-03
3926 Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics
Nolan, A.; Zeden, M. S.; Campbell, C.; Kviatkovski, I.; Urwin, L.; Corrigan, R. M.; Gründling, A.; O'Gara, J. P.
10.1101/2022.09.01.506298 — microbiology — Posted on 2022-09-03
3927 Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales
Zou, F.; Guo, W.; Allen, E. J.; Wu, Y.; Charest, I.; Naselaris, T.; Kay, K.; Kuhl, B. A.; Hutchinson, J. B.; DuBrow, S.
10.1101/2022.08.31.506090 — neuroscience — Posted on 2022-09-03
3929 Associations between thinner retinal neuronal layers and suboptimal brain structural integrity: Are the eyes a window to the brain?
Barrett-Young, A.; Abraham, W. C.; Cheung, C. Y.; Gale, J.; Hogan, S.; Ireland, D.; Keenan, R.; Knodt, A. R.; Melzer, T. R.; Moffitt, T. E.; Ramrakha, S.; Tham, Y. C.; Wilson, G. A.; Wong, T. Y.; Hariri, A. R.; Poulton, R.
10.1101/2022.08.31.506114 — neuroscience — Posted on 2022-09-03
3930 CRF Neurons Establish Resilience via Stress-History-Dependent BNST Modulation
Haynes, S. E.; Seo, H. S.; Lacagnina, A.; Morel, C.; Afzal, M. F.; Menigoz, A.; Clem, R.; Rajan, K.; Mayberg, H.; Young, L.; Han, M.-H.
10.1101/2022.08.31.505596 — neuroscience — Posted on 2022-09-03
3931 Lifespan differences in visual short-term memory load-modulated functional connectivity
Lugtmeijer, S.; Geerligs, L.; Tsvetanov, K. A.; Mitchell, D. J.; Campbell, K. L.
10.1101/2022.08.31.506084 — neuroscience — Posted on 2022-09-03
3933 Excitation creates a distributed pattern of cortical suppression due to varied recurrent input
O'Rawe, J. F.; Zhou, Z.; Li, A. J.; LaFosse, P. K.; Goldbach, H. C.; Histed, M. H.
10.1101/2022.08.31.505844 — neuroscience — Posted on 2022-09-03
3935 Age and musical training effects on auditory short-term, long-term, and working memory
Rubio, G. F.; Olsen, E. R.; Klarlund, M.; Mallon, O.; Carlomagno, F.; Vuust, P.; Kringelbach, M. L.; Brattico, E.; Bonetti, L.
10.1101/2022.08.31.506048 — neuroscience — Posted on 2022-09-03
3937 Pten regulates endocytic trafficking of cell adhesion and signaling molecules to pattern the retina
Touahri, Y.; Hanna, J.; Tachibana, N.; David, L. A.; Olender, T.; Okawa, S.; Chinchalongporn, V.; Balakrishnan, A.; Cantrup, R.; Dixit, R.; Mattar, P.; Saleh, F.; Ilnytskyy, Y.; Murshed, M.; Mains, P.; Kovalchuk, I.; Lefebvre, J.; Cayouette, M.; del Sol, A.; Brand, M.; Reese, B. E.; Schuurmans, C.
10.1101/2022.08.31.506085 — neuroscience — Posted on 2022-09-03
3938 A model-free approach to link neural activity to behavioral tasks
Costabile, J. D.; Balakrishnan, K. A.; Schwinn, S.; Haesemeyer, M.
10.1101/2022.08.31.506108 — neuroscience — Posted on 2022-09-03
3940 A genome-scale atlas reveals complex interplay of transcription and translation in an archaeon
Lorenzetti, A. P. R.; Kusebauch, U.; Zaramela, L. S.; Wu, W.-J.; de Almeida, J. P. P.; Turkarslan, S.; de Lomana, A. L. G.; Gomes-Filho, J. V.; Vencio, R. Z. N.; Moritz, R. L.; Koide, T.; Baliga, N. S.
10.1101/2022.08.31.505529 — systems biology — Posted on 2022-09-03
3943 Gain-of-function dynamin-2 mutations linked to centronuclear myopathy impair Ca2+-induced exocytosis in human myoblasts
Bayones, L.; Fernandez, M. J. G.; Hinostroza, F.; Matus, X. B.; Navarrete, J. V.; Gallo, L. I.; Parra, S.; Martinez, A. D.; Jamett, A. G.; Marengo, F. D.; Cardenas, A. M.
10.1101/2022.08.31.506089 — physiology — Posted on 2022-09-03
3946 Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance
Maitituoheti, M.; Shi, A.; Tang, M.; Ho, L.-L.; Terranova, C.; Galani, K.; Keung, E.; Creasy, C.; Wu, M.; Chen, J.; Chen, N.; Singh, A.; Chaudhri, A.; Anvar, N.; Tarantino, G.; Yang, J.; Sarkar, S.; Jiang, S.; Malke, J.; Hayudu, L.; Burton, E.; Davies, M.; Gershenwald, J.; Hwu, P.; Lazar, A.; Cheah, J.; Soule, C.; Levine, S.; Bernatchez, C.; Saladi, S.; Liu, D.; Wargo, J.; Boland, G.; Kellis, M.; Rai, K.
10.1101/2022.08.31.506051 — cancer biology — Posted on 2022-09-03
3947 STAT3 cooperates with the core transcriptional regulatory circuitry to drive MYC expression and oncogenesis in anaplastic large cell lymphoma
Prutsch, N.; He, S.; Berezovskaya, A.; Durbin, A. D.; Dharia, N. V.; Stegmaier, K.; Matthews, J. D.; Hare, L.; Turner, S. D.; Kenner, L.; Merkel, O.; Young, R. A.; Abraham, B. J.; Look, A. T.; Zimmerman, M. W.
10.1101/2022.08.31.506044 — cancer biology — Posted on 2022-09-03
3949 Modeling the biomechanics of cells on microcarriers in a stirred-tank bioreactor An ABM-CFD coupling approach
Camphuijsen, J.; Cantarero Rivera, F. J.; Potter, G.; Clark, C.; Chen, J.; Kahan, S.; Aguilar, B.
10.1101/2022.08.31.505282 — bioinformatics — Posted on 2022-09-03
3953 Refining Embedding-Based Binding Predictions by Leveraging AlphaFold2 Structures
Endres, L.; Olenyi, T.; Erckert, K. Y.; Weissenow, K.; Rost, B.; Littmann, M.
10.1101/2022.08.31.505997 — bioinformatics — Posted on 2022-09-03
3954 A two-compartment system for subfreezing temperatures preservation of large volumes of organic matter in an isochoric system
Nastase, G.; Botea, F.; Beschea, G. A.; Campean, S. I.; Barcu, A.; Popescu, I.; Rubinsky, B.; Serban, A.
10.1101/2022.08.31.506083 — bioengineering — Posted on 2022-09-03
3955 A Camera-Assisted Pathology Microscope to Capture the Lost Data in Clinical Glass Slide Diagnosis
Ashman, K.; Cooper, M. S.; Zhuge, H.; Fox, S. E.; Epstein, J. I.; Wenk, C.; Summa, B.; Brown, J. Q.
10.1101/2022.08.31.506042 — bioengineering — Posted on 2022-09-03
3957 Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity
Romeo, S. G.; Secco, I.; Schneider, E.; Reumiller, C. M.; Santos, C. X.; Pooni, A.; Yin, X.; Theofilatos, K.; Cellone Trevelin, S.; Zeng, L.; Mann, G. E.; Margariti, A.; Mayr, M.; Shah, A. M.; Giacca, M.; Zampetaki, A.
10.1101/2022.09.01.505804 — cell biology — Posted on 2022-09-03
3958 MAM-STAT3-induced upregulation of mitochondrial Ca+2 causes immunosenescence in patients with type A mandibuloacral dysplasia
Padhiar, A. A.; Yang, X.; Li, Z.; Liao, J.; Ali, I.; Shu, W.; Chishti, A. A.; He, L.; Alam, G.; Faqeer, A.; Zhou, Y.; Zhang, S.; Wang, T.; Liu, T.; Zhou, M.; Wang, G.; Zou, X.; Zhou, G.
10.1101/2022.08.31.504639 — cell biology — Posted on 2022-09-03
3959 Transcriptional changes in human palate and skin healing
Leonardo, T. R.; Chen, L.; Schrementi, M. E.; Shi, J.; Marucha, P. T.; Glass, K.; DiPietro, L. A.
10.1101/2022.09.01.506279 — cell biology — Posted on 2022-09-03
3960 Hsp90 provides a platform for kinase dephosphorylation by PP5
Jaime-Garza, M.; Nowotny, C. A.; Coutandin, D.; Wang, F.; Tabios, M.; Agard, D. A.
10.1101/2022.09.02.506407 — biophysics — Posted on 2022-09-03
3961 FDA-Approved Drug Screening in Patient-Derived Organoids Demonstrates Potential of Drug Repurposing for Rare Cystic Fibrosis Genotypes
de Poel, E.; Spelier, S.; Hagemeijer, M. C.; van Mourik, P.; Suen, S. W. F.; Vonk, A. M.; Brunsveld, J. E.; Ithakisiou, G. N.; Kruisselbrink, E.; Oppelaar, H.; Berkers, G.; de Winter-de Groot, K. M.; Heida-Michel, S.; Jans, S. R.; van Panhuis, H.; Bakker, M.; van der Meer, R.; Roukema, J.; Dompeling, E.; Weersink, E. J. M.; Koppelman, G. H.; Blaazer, A. R.; van Muijlwijk - Koezen, J. E.; van der Ent, C. K.; Beekman, J. M.
10.1101/2022.09.02.506304 — molecular biology — Posted on 2022-09-03
3962 A cryogenic, coincident fluorescence, electron and ion beam microscope
Boltje, D.; Hoogenboom, J.; Jakobi, A. J.; Jensen, G. J.; Jonker, C.; Kaag, M.; Koster, A. J.; Last, M.; de Agrela Pinto, C.; Plitzko, J. M.; Raunser, S.; Tacke, S.; Wang, Z.; van der Wee, E.; Wepf, R.; den Hoedt, S.
10.1101/2022.09.02.506334 — molecular biology — Posted on 2022-09-03
3963 Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics
Nolan, A.; Zeden, M. S.; Campbell, C.; Kviatkovski, I.; Urwin, L.; Corrigan, R. M.; Gründling, A.; O'Gara, J. P.
10.1101/2022.09.01.506298 — microbiology — Posted on 2022-09-03
3964 Cell-intrinsic ceramides determine T cell function during melanoma progression
Hose, M.; Günther, A.; Naser, E.; Schumacher, F.; Schönberger, T.; Falkenstein, J.; Papadamakis, A.; Kleuser, B.; Becker, K. A.; Gulbins, E.; Haimovitz-Friedman, A.; Buer, J.; Westendorf, A.; Hansen, W.
10.1101/2022.08.31.505996 — immunology — Posted on 2022-09-03
3968 CRISPR-Analytics (CRISPR-A): a platform for precise analytics and simulations for gene editing
Sanvicente, M.; Garcia-Valiente, A.; Jouide, S.; Jaraba-Wallace, J.; Bautista, E.; Escobosa, M.; Sanchez-Mejias, A.; Güell, M.
10.1101/2022.09.02.506351 — bioinformatics — Posted on 2022-09-03
3969 Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle.
McNamara, J. W.; Parker, B. L.; Voges, H. K.; Mehdiabadi, N. R. R.; Bolk, F.; Chung, D. D.; Charitakis, N.; Molendijk, J.; Lal, S.; Ramialison, M.; Karavendzas, K.; Pointer, H. L.; Syrris, P.; Lopes, L. R.; Perry, E. M.; Lynch, G. S.; Mills, R. J.; Hudson, J. E.; Watt, K. I.; Porrello, E. R.; Elliott, D. A.
10.1101/2022.09.01.506029 — cell biology — Posted on 2022-09-03
3970 A TetR-like transcriptional regulator in Stenotrophomonas maltophilia involved in fatty acid metabolism is controlled by quorum sensing signals
Coves, X.; Huedo, P.; Bravo, M.; Conchillo-Sole, O.; Gomez, A.-C.; Esteve-Codina, A.; Dabad, M.; Gut, M.; Daura, X.; Yero, D.; Gibert, I.
10.1101/2022.08.31.506136 — microbiology — Posted on 2022-09-03
3972 Prosocial behavior in adult mice is sex-dependent
Misiolek, K.; Klimczak, M.; Chroszcz, M.; Szumiec, L.; Bryksa, A.; Przyborowicz, K.; Rodriguez Parkitna, J.; Harda, Z.
10.1101/2022.08.19.504492 — animal behavior and cognition — Posted on 2022-09-03
3973 Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer's disease mouse model: a role for ER-mitochondria interaction.
Tapella, L.; Dematteis, G.; Moro, M.; Pistolato, B.; Tonelli, E.; Vanella, V. V.; Giustina, D.; La Forgia, A.; Restelli, E.; Barberis, E.; Villani, S.; Del Grosso, E.; Grilli, M.; Manfredi, M.; Corazzari, M.; Grolla, A. A.; Genazzani, A. A.; Lim, D.
10.1101/2022.03.24.485644 — neuroscience — Posted on 2022-09-03
3974 Astrocytes regulate inhibition in Fragile X Syndrome
Rais, M.; Kulinich, A. O.; Wagner, V.; Woodard, W.; Shuai, X. S.; Suley, S. N.; Kokash, J.; Piepponen, T. P.; Castren, M.; Razak, K.; Ethell, I.
10.1101/2022.02.08.479618 — neuroscience — Posted on 2022-09-03
3975 Sex biases in cancer and autoimmune disease incidence are strongly positively correlated with mitochondrial gene expression across human tissues
Crawford, D. R.; Sinha, S.; Nair, N. U.; Ryan, B. M.; Barnholtz-Sloan, J. S.; Mount, S. M.; Erez, A.; Aldape, K.; Castle, P. E.; Rajagopal, P. S.; Day, C.-P.; Schäffer, A. A.; Ruppin, E.
10.1101/2021.09.07.459207 — cancer biology — Posted on 2022-09-03
3976 Tri-dimensional Mitochondria Reconstructions of Cardiac Muscle Changes in Size Across Aging due to the MICOS Complex
Vue, Z.; Neikirk, K.; Vang, L.; Garza Lopez, E.; Christensen, T. A.; Shao, J.; Lam, J.; Beasley, H.; Marshall, A.; Crabtree, A.; Anudokem, J.; Rodriguez, B.; Kirk, B.; Bacevac, S.; Barongan, T.; Shao, B.; Evans, C.; Taylor, B.; Reddy, A. K.; Murray, S. A.; Mobley, B. C.; Gomez, J. A.; Phillips, M.; Exil, V.; Dai, D.-F.; Hinton, A.
10.1101/2022.04.23.489291 — biophysics — Posted on 2022-09-03
3977 ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis
Raslova, H.; Basso-Valentina, F.; Donada, A.; Manchev, V. T.; Lisetto, M.; Balayn, N.; Martin, J.-E.; Muller, D.; Marin Oyarzun, C. P.; Duparc, H.; Arkoun, B.; Cumin, A.; Droin, N.; Faivre, L.; Biunno, I.; Balduini, A.; Debili, N.; Antony-Debre, I.; Marty, C.; Vainchenker, W.; Plo, I.; Favier, R.
10.1101/2022.09.01.506160 — cell biology — Posted on 2022-09-03
3980 NF-κB Decoy ODN-Loaded Poly lactic-co-glycolic Acid Nanospheres Inhibit Alveolar Ridge Resorption
Huang, A. C. S.; Ishida, Y.; Li, K.; Rintanalert, D.; Hatano-sato, K.; Oishi, S.; Hosomichi, J.; Usumi-Fujita, R.; Yamaguchi, H.; Tsujimoto, H.; Sasai, A.; Ochi, A.; Watanabe, H.; Ono, T.
10.1101/2022.08.30.505814 — immunology — Posted on 2022-09-02
3981 Ventral temporal and posteromedial sulcal morphology in autism spectrum disorder
Benitez, J. A. R.; Kannan, S.; Hastings, W.; Parker, B.; Willbrand, E.; Weiner, K. S.
10.1101/2022.09.01.506213 — neuroscience — Posted on 2022-09-02
3984 Developmental shift in testosterone influence on prefrontal emotion control
Tyborowska, A.; Volman, I.; Niermann, H. C. M.; Dapprich, A. L.; Smeekens, S.; Cillessen, A. H. N.; Toni, I.; Roelofs, K.
10.1101/2022.09.02.505577 — neuroscience — Posted on 2022-09-02
3985 Hippocampal-cortical functional connectivity during memory encoding and retrieval
Raud, L.; Sneve, M. H.; Vidal-Pineiro, D.; Sorensen, O.; Folvik, L.; Ness, H. T.; Mowinckel, A. M.; Grydeland, H.; Walhovd, K. B.; Fjell, A. M.
10.1101/2022.09.02.506311 — neuroscience — Posted on 2022-09-02
3989 Fluorescent peptomer substrates for differential degradation by metalloproteases
Austin, M. J.; Schunk, H. C.; Watkins, C. M.; Ling, N. R.; Chauvin, J. M.; Morton, L. D.; Rosales, A. M.
10.1101/2022.08.31.506126 — biochemistry — Posted on 2022-09-02
3990 Structural Basis for pre-tRNA Recognition and Processing by the Human tRNA Splicing Endonuclease Complex
Hayne, C. K.; Butay, K. J. U.; Stewart, Z. D.; Krahn, J. M.; Perera, L.; Williams, J. G.; Petrovitch, R. M.; Deterding, L. J.; Matera, G.; Borgnia, M. J.; Stanley, R. E.
10.1101/2022.09.02.506201 — biochemistry — Posted on 2022-09-02
3991 Population structure and evolution of Salmonella enterica serotype Typhi in Zimbabwe before a typhoid conjugate vaccine immunization campaign
Thilliez, G.; Mashe, T.; Chaibva, B. V.; Robertson, V.; Bawn, M.; Tarupiwa, A.; Takawira, F. T.; Kock, M. M.; Midzi, S.; Mwamakamba, L. W.; Matheu, J.; Kingsley, R. A.; Ehlers, M. M.
10.1101/2022.09.01.506167 — genomics — Posted on 2022-09-02
3993 Disentangling marine microbial networks across space
Deutschmann, I. M.; Delage, E.; Giner, C. R.; Sebastian, M.; Poulain, J.; Aristegui, J.; Duarte, C. M.; Acinas, S. G.; Massana, R.; Gasol, J. M.; Eveillard, D.; Chaffron, S.; Logares, R.
10.1101/2021.07.12.451729 — microbiology — Posted on 2022-09-02
3995 MHC-II expressing neutrophils circulate in blood and milk during mastitis and show high microbicidal activity
Rambault, M.; Gilbert, F. B.; Roussel, P.; Tessier, A.; David, V.; Germon, P.; Winter, N.; Remot, A.
10.1101/2022.09.01.506187 — immunology — Posted on 2022-09-02
3996 Texture coding in higher order somatosensory cortices of primates
Long, K. H.; Greenspon, C. M.; van Driesche, A.; Lieber, J. D.; Bensmaia, S. J.
10.1101/2022.08.19.504511 — neuroscience — Posted on 2022-09-02
3998 Attenuation of polysialic acid biosynthesis in cells by the small molecule inhibitor 8-keto-sialic acid
Hunter, C.; Gao, Z.; Chen, H.-M.; Thompson, N.; Wakarchuk, W.; nitz, m.; Withers, S.; Willis, L. M.
10.1101/2022.09.02.506362 — biochemistry — Posted on 2022-09-02
4001 Differential scanning fluorimetry as a measure of functionality of refolded anti-malarial antibody fragments
Valiyaparambil, A.; Jagannath, D. K.; Viswanath, V. K.; Kumar, N.; Shukla, J. P.; Pradhan, S.; Lakshminarasimhan, A.
10.1101/2022.09.01.504486 — biochemistry — Posted on 2022-09-02
4002 Copper as a Novel Regulator of PERK
Bond, S. E.; Beratan, N. R.; Bond, M. K.; Brady, D. C.; Jordan-Sciutto, K. L.
10.1101/2022.09.02.506340 — biochemistry — Posted on 2022-09-02
4004 Derivation of a minimal functional XIST by combining human and mouse interaction domains
Brown, C. J.; Navarro Cobos, M. J.; Baldry, S. E. L.; Morales Guzman, S. I.
10.1101/2022.09.02.506429 — genetics — Posted on 2022-09-02
4006 CRTC-1 Balances Histone Trimethylation and Acetylation to Promote Longevity
Silva-Garcia, C. G.; Lascarez-Lagunas, L. I.; Heintz, C.; Papsdorf, K.; Pajuelo, L.; Sharma, A.; Colaiacovo, M. P.; Brunet, A.; Mair, W. B.
10.1101/2022.08.31.506037 — genetics — Posted on 2022-09-02
4007 A role for BCL2L13 and autophagy in germline purifying selection of mtDNA
Kremer, L. S.; Bozhilova, L. V.; Rubalcava-Gracia, D.; Filograna, R.; Upadhyay, M.; Koolmeister, C.; Chinnery, P. F.; Larsson, N.-G.
10.1101/2022.09.02.506367 — genetics — Posted on 2022-09-02
4008 Intracellular pH dynamics regulates intestinal stem cell lineage specification
Liu, Y.; Reyes, E.; Castillo-Azofeifa, D.; Klein, O. D.; Barber, D. L.; Nystul, T.
10.1101/2021.10.28.466337 — developmental biology — Posted on 2022-09-02
4009 Distinguishing Signal from Noise: Understanding Patterns of Non-Detections to Inform Accurate Quantitative Metabarcoding
Gold, Z.; Shelton, A. O.; Casendino, H. R.; Duprey, J.; Gallego, R.; Van Cise, A.; Fisher, M.; Jensen, A. J.; D'Agnese, E.; Andruszkiewicz Allan, E.; Ramon-Laca, A.; Garber-Yonts, M.; Labare, M.; Parsons, K. M.; Kelly, R. P.
10.1101/2022.09.02.506420 — molecular biology — Posted on 2022-09-02
4013 Machine learning identification of Pseudomonas aeruginosa strains from colony image data
Rattray, J. B.; Walden, R.; Marquez Zacarias, P.; Molotkova, E.; Perron, G.; Solis-Lemus, C.; Pimentel-Alarcon, D.; Brown, S. P.
10.1101/2022.09.02.506375 — microbiology — Posted on 2022-09-02
4015 Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy
Kennedy, K.; Plagemann, A.; Sommer, J.; Hofmann, M.; Henrich, W.; Barrett, J. F. R.; Surette, M. G.; Atkinson, S.; Braun, T.; Sloboda, D. M.
10.1101/2022.09.02.506244 — microbiology — Posted on 2022-09-02
4016 Diversity and ecology of Caudoviricetes phages with genome terminal repeats in fecal metagenomes from four Dutch cohorts
Gulyaeva, A.; Garmaeva, S.; Kurilshikov, A.; Vich Vila, A.; Riksen, N. P.; Netea, M. G.; Weersma, R. K.; Fu, J.; Zhernakova, A.
10.1101/2022.09.02.506393 — microbiology — Posted on 2022-09-02
4017 Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection
Coldbeck-Shackley, R.; Romeo, O.; Rosli, S.; Gearing, L. J.; Gould, J. A.; Lim, S. S.; Van der Hoek, K.; Eyre, N. S.; Shue, B.; Robertson, S. A.; Best, S. M.; Tate, M. D.; Hertzog, P.; Beard, M. R.
10.1101/2022.09.01.505971 — immunology — Posted on 2022-09-02
4018 Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of HIV-infection and Aging
Kumar, A.; Wang, J.; Zhou, H.; Radcliffe, C.; Vander Wyk, B.; Allore, H.; Tsang, S.; Barakat, L.; Mohanty, S.; Zhao, H.-y.; Shaw, A.; Zapata, H.
10.1101/2022.09.01.505710 — immunology — Posted on 2022-09-02
4019 Transcriptional and clonal characterization of cytotoxic CD8+ T cells in crescentic glomerulonephritis
Zhao, Y.; Mueller, A.; Cicek, H.; Paust, H.-J.; Sivayoganathan, A.; Linke, A.; Wegscheid, C.; Wiech, T.; Huber, T. B.; Meyer-Schwesinger, C.; Bonn, S.; Panzer, U. P.; Tiegs, G.; Krebs, C. F.; Neumann, K.
10.1101/2022.08.31.506004 — immunology — Posted on 2022-09-02
4023 Improved Genome Editing by an Engineered CRISPR-Cas12a
Ma, E.; Chen, K.; Shi, H.; Stahl, E. C.; Adler, B. A.; Liu, J.; Zhou, K.; Ye, J.; Doudna, J. A.
10.1101/2022.09.02.506401 — biochemistry — Posted on 2022-09-02
4025 A thousand-genome panel retraces the global spread and climatic adaptation of a major crop pathogen
Feurtey, A.; Lorrain, C.; McDonald, M. C.; Milgate, A.; Solomon, P.; Warren, R.; Puccetti, G.; Scalliet, G.; Torriani, S.; Gout, L.; Marcel, T.; Suffert, F.; Alassimone, J.; Lipzen, A.; Yoshinaga, Y.; Daum, C.; Barry, K.; Grigoriev, I. V.; Goodwin, S. B.; Genissel, A.; Seidl, M. F.; Stukenbrock, E. H.; Lebrun, M.-H.; Kema, G. H. J.; McDonald, B. A.; Croll, D.
10.1101/2022.08.26.505378 — genomics — Posted on 2022-09-02
4026 Targeted insertion of reporter transgene into a gene safe harbor in human blood fluke, Schistosoma mansoni
Tanno, W. I.; Moscheid, M. F.; Chaparro, C.; Mann, V. H.; Quack, T.; Rodpai, R.; Miller, A. N.; Wistiphongpun, P.; Buakaew, W.; Mentink-Kane, M.; Miller, L.; Schmid, S.; Popratiloff, A.; Hoffmann, K. F.; Grevelding, C.; Grunau, C.; Brindley, P. J.
10.1101/2022.09.02.506379 — molecular biology — Posted on 2022-09-02
4027 VSGs expressed during natural T. b. gambiense infection exhibit extensive sequence divergence and a subspecies-specific expression bias
So, J.; Sudlow, S.; Sayeed, A.; Grudda, T.; Deborggraeve, S.; Ngoyi, D. M.; Desamber, D. K.; Wickstead, B.; Lejon, V.; Mugnier, M. R.
10.1101/2021.09.09.459620 — microbiology — Posted on 2022-09-02
4033 3D Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast
Lewis, R.; Baskaran, H.; Green, J.; Tashev, S.; Palaiologou, E.; Lofthouse, E. M.; Cleal, J. K.; Page, A.; Chatelet, D.; Goggin, P.; Sengers, B. G.
10.1101/2022.01.26.477815 — physiology — Posted on 2022-09-02
4034 Mammary Tissue-Derived Extracellular Matrix Hydrogels Reveal the Role of the Irradiated Microenvironment in Breast Cancer Recurrence
Zhu, T.; Alves, S. M.; Adamo, A.; Wen, X.; Corn, K. C.; Shostak, A.; Shaub, N. D.; Hacker, B. C.; D'Amore, A.; Bardhan, R.; Rafat, M.
10.1101/2022.05.16.492117 — cancer biology — Posted on 2022-09-02
4035 Novel eDNA approaches to monitor Western honey bee (Apis mellifera) microbial and arthropod communities
Boardman, L.; Marcelino, J. A.; Valentin, R.; Boncristiani, H.; Standley, J.; Ellis, J. D.
10.1101/2022.08.31.506105 — ecology — Posted on 2022-09-02
4037 Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA
PISAREVA, E.; Mihalovicova, L.; Pastor, B.; Kudriavstev, A.; Mirandola, A.; Mazard, T.; Badiou, S.; Maus, U.; Ostermann, L.; Weinmann-Menke, J.; neuberger, E.; simon, P.; THIERRY, A.
10.1101/2022.09.01.506266 — molecular biology — Posted on 2022-09-02
4038 Novel monoclonal antibodies showing broad neutralizing activity for SARS-CoV-2 variants including Omicrons BA.5 and BA.2.75
Ishimaru, H.; Nishimura, M.; Tjan, L. H.; Sutandhio, S.; Marini, M. I.; Effendi, G. B.; Shigematsu, H.; Kato, K.; Hasegawa, N.; Aoki, K.; Kurahashi, Y.; Furukawa, K.; Shinohara, M.; Nakamura, T.; Arii, J.; Nagno, T.; Nakamura, S.; Sano, S.; Iwata, S.; Mori, Y.
10.1101/2022.09.02.506305 — microbiology — Posted on 2022-09-02
4039 White-tailed deer (Odocoileus virginianus) may serve as a wildlife reservoir for nearly extinct SARS-CoV-2 variants of concern
Caserta, L. C.; Martins, M.; Butt, S. L.; Hollingshead, N.; Covaleda, L. M.; Everts, M.; Schuler, K.; Diel, D. G.
10.1101/2022.09.02.506368 — microbiology — Posted on 2022-09-02
4040 SARS-CoV-2 nucleocapsid protein inhibits the stress response through RNA-binding domain N2b
Aloise, C.; Schipper, J. G.; Donselaar, T.; Hurdiss, D. L.; de Groot, R. J.; van Kuppeveld, F. J. M.
10.1101/2022.09.02.506332 — microbiology — Posted on 2022-09-02
4041 Growth hormone receptor (GHR) in AgRP neurons regulatesthermogenesis in aged mice in a sex-specific manner
Stilgenbauer, L.; de Lima, J. B. M.; Debarba, L. K.; Khan, M.; Koshko, L.; Kopchick, J. J.; Bartke, A.; Schneider, A.; Sadagurski, M.
10.1101/2022.08.31.506031 — neuroscience — Posted on 2022-09-02
4045 Photosystem II monomeric antenna CP26 has a key role in Non-Photochemical Quenching in Chlamydomonas reinhardtii
Cazzaniga, S.; Kim, M.; Pivato, M.; Perozeni, F.; Sardar, S.; D'Andrea, C.; Jin, E.; Ballottari, M.
10.1101/2022.09.01.506249 — plant biology — Posted on 2022-09-02
4048 Comparative phylotranscriptomics reveals a 110 million years-old symbiotic program
Libourel, C.; Keller, J.; Brichet, L.; Cazale, A.-C.; Carrere, S.; Vernie, T.; Couzigou, J.-M.; Callot, C.; Dufau, I.; Cauet, S.; Marande, W.; Bulach, T.; Suin, A.; Masson-Boivin, C.; Remigi, P.; Delaux, P.-M.; Capela, D.
10.1101/2022.09.02.505815 — plant biology — Posted on 2022-09-02
4049 In situ imaging across ecosystems to resolve the fine-scale oceanographic drivers of a globally significant planktonic grazer
Greer, A. T.; Schmid, M. S.; Duffy, P. I.; Robinson, K. L.; Genung, M. A.; Luo, J. Y.; Panaiotis, T.; Briseno-Avena, C.; Frischer, M. E.; Sponaugle, S.; Cowen, R. K.
10.1101/2022.08.31.506093 — ecology — Posted on 2022-09-02
4050 Habitat use differences mediate anthropogenic threat exposure in white sturgeon
Walter, J. A.; Singer, G. P.; Reuman, D. C.; Colborne, S. F.; Sheppard, L. W.; O'Donnell, D. R.; Coombs, N.; Johnston, M.; Miller, E. A.; Steel, A. E.; Kelly, J. T.; Fangue, N. A.; Rypel, A. L.
10.1101/2022.08.31.505999 — ecology — Posted on 2022-09-02
4053 Activation of ERK by altered RNA splicing in cancer
Zhang, Y.; Siraj, M. A.; Chakraborty, P.; Tseng, R.; Ku, L.-T.; Das, S.; Dey, A.; Dwivedi, S. K. D.; Rao, G.; Zhang, M.; Yang, D.; Hossen, M. N.; Ding, W.-Q.; Fung, K.-M.; Bhattacharya, R.; Escobar-Hoyos, L.; Mukherjee, P.
10.1101/2022.08.31.505957 — cancer biology — Posted on 2022-09-02
4054 Correlating viscosity and molecular crowding with fluorescent nanobeads and molecular probes: in vitro and in vivo
Lecinski, S.; Shepherd, J. W.; Bunting, K.; Dresser, L.; Quinn, S. D.; MacDonald, C.; Leake, M. C.
10.1101/2022.06.27.497768 — biophysics — Posted on 2022-09-02
4056 Succinate mediates inflammation-induced adrenocortical dysfunction
Mateska, I.; Witt, A.; Hagag, E.; Sinha, A.; Yilmaz, C.; Thanou, E.; Sun, N.; Kolliniati, O.; Patschin, M.; Abdelmegeed, H.; Henneicke, H.; Kanczkowski, W.; Wielockx, B.; Tsatsanis, C.; Dahl, A.; Walch, A.; Li, K. W.; Peitzsch, M.; Chavakis, T.; Alexaki, V. I.
10.1101/2022.04.29.490066 — immunology — Posted on 2022-09-02
4061 Hemisynthetic derivatives of the natural alkaloid trilobine are fast-acting antimalarial compounds with sustained activity in multi-drug resistant P. falciparum isolates
Nardella, F.; Dobrescu, I.; Hassan, H.; Rodrigues, F.; Thiberge, S.; Mancio, L.; Tafit, A.; Jallet, C.; Cadet-Daniel, V.; Goussin, S.; Lorthiois, A.; Menon, Y.; Molinier, N.; Pechalrieu, D.; Long, C.; Sautel, F.; Matondo, M.; Duchateau, M.; Medard, G.; Witkowski, B.; Scherf, A.; Halby, L.; Arimondo, P. B.
10.1101/2022.08.30.505923 — pathology — Posted on 2022-09-02
4062 Spatial analysis of the metastatic brain tumor immune and extracellular matrix microenvironment
Widodo, S. S.; Dinevska, M.; Cuzcano, L. R.; Papanicolaou, M.; Cox, T. R.; Stylli, S. S.; Mantamadiotis, T.
10.1101/2022.08.30.505945 — cancer biology — Posted on 2022-09-02
4063 A Comprehensive Enumeration of the Human Proteostasis Network. 1. Components of Translation, Protein Folding, and Organelle-Specific Systems
The Proteostasis Consortium, ; Elsasser, S.; Finley, D.; Mockler, E.; Lima, L.; Finkbeiner, S.; Gestwicki, J. E.; Stoeger, T. E.; Cao, K.; Garza, D.; Kelly, J. W.; Collier, M.; Rainbolt, T. K.; Taguwa, S.; Chou, C.-C.; Aviner, R.; Barbosa, N.; Moralez-Polanco, F.; Masto, V. B.; Frydman, J.; Elia, L. P.; Morimoto, R. I.; Powers, E. T.
10.1101/2022.08.30.505920 — bioinformatics — Posted on 2022-09-02
4067 Incidental Temporal Binding in Rats: A Novel Behavioral Task Relevant to Episodic Memory
Radostova, D.; Kuncicka, D.; Krajcovic, B.; Hejtmanek, L.; Petrasek, T.; Svoboda, J.; Stuchlik, A.; Brozka, H.
10.1101/2022.08.30.505895 — animal behavior and cognition — Posted on 2022-09-02
4068 ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE
Lai, C.; Alvarez, O.; Read, K.; van Fossan, D.; Conner, C. M.; Xu, S. X.-R.; Cowley, D. O.; Gantz, V.; Webb, D. R.; Jarnagin, K.
10.1101/2022.08.30.505951 — genetics — Posted on 2022-09-02
4069 Coenzyme A governs proinflammatory macrophage metabolism
Timblin, G. A.; Tharp, K. M.; Hoeve, J. t.; Baydemir, I.; Khantwal, C.; Farahzad, J. N.; Dominguez-Andres, J.; Vance, R. E.; Weaver, V. M.
10.1101/2022.08.30.505732 — immunology — Posted on 2022-09-02
4071 Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
Licht-Murava, A.; Meadows, S. M.; Palaguachi, F.; Song, S. C.; Bram, Y.; Zhou, C.; Jackvony, S.; Schwartz, R. E.; Froemke, R. C.; Orr, A. L.; Orr, A. G.
10.1101/2022.08.30.503668 — neuroscience — Posted on 2022-09-02
4072 Profound lipid dysregulation in mutant TDP-43 mice is ameliorated by the glucocerebrosidase 2 inhibitor ambroxol
Luikinga, S. J.; Henriques, A.; Ngo, S.; Rupasinghe, T.; Loeffler, J.-P.; Spedding, M.; Turner, B. J.
10.1101/2022.08.30.505901 — neuroscience — Posted on 2022-09-02
4073 Cinemeducation improves early clinical exposure to Inborn Errors of Metabolism
Dutta, A. K.; Oberoi, A.; Goswami, K.; Modi, J. N.; Goyal, P. K.; Samuel, S.; Mondal, T.; Sahoo, S.; Pal, A.
10.1101/2022.08.30.505958 — scientific communication and education — Posted on 2022-09-02
4078 High-grade serous ovarian carcinoma organoids as models of chromosomal instability
Vias, M.; Morrill Gavarro, L.; Sauer, C. M.; Sanders, D.; Piskorz, A. M.; Couturier, D.-L.; Ballereau, S.; Hernando, B.; Hall, J.; Correia-Martins, F.; Markowetz, F.; Macintyre, G.; Brenton, J. D.
10.1101/2022.09.01.506155 — cancer biology — Posted on 2022-09-02
4083 Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids
Costa, B.; Li Calzi, M.; Castellano, M.; Blanco, V.; Cuevasanta, E.; Litvan, I.; Ivanov, P.; Witwer, K.; Cayota, A.; Tosar, J. P.
10.1101/2022.08.31.506125 — molecular biology — Posted on 2022-09-02
4085 Molecular Determinants for Differential Activation of the Vibrio parahaemolyticus Bile Acid Receptor
Zou, A.; Kinch, L. N.; Chimalapati, S.; Garcia Rodriguez, N.; Tomchick, D. R.; Orth, K.
10.1101/2022.09.02.506320 — microbiology — Posted on 2022-09-02
4087 Synthetic genotype networks
Santos-Moreno, J.; Tasiudi, E.; Kusumawardhani, H.; Stelling, J.; Schaerli, Y.
10.1101/2022.09.01.506159 — synthetic biology — Posted on 2022-09-02
4088 Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity
Kim, D.; Biancon, G.; Bai, Z.; VanOudenhove, J.; Liu, Y.; Kothari, S.; Gowda, L.; Kwan, J. M.; Buitrago-Pocasangre, N. C.; Lele, N.; Asashima, H.; Racke, M. K.; Wilson, J. E.; Givens, T. S.; Tomayko, M. M.; Schulz, W. L.; Longbrake, E. E.; Hafler, D. A.; Halene, S.; Fan, R.
10.1101/2022.08.31.506117 — bioengineering — Posted on 2022-09-02
4090 When two is a crowd - Structural mapping of PEAK pseudokinase interactions identifies 14 3 3 as a molecular switch for PEAK3/Crk signaling.
Roy, M. J.; Surudoi, M. G.; Kropp, A.; Hou, J.; Dai, W.; Hardy, J. M.; Liang, L.-Y.; Cotton, T. R.; Lechenberg, B. C.; Dite, T. A.; Ma, X.; Daly, R. J.; Patel, O.; Lucet, I.
10.1101/2022.09.01.506260 — biochemistry — Posted on 2022-09-02
4093 Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis
Hampton, B. K.; Plante, K. S.; Whitmore, A. C.; Linnertz, C. L.; Madden, E. A.; Noll, K. E.; Boyson, S. P.; Parotti, B.; Bell, T. A.; Hock, P.; Shaw, G. D.; Pardo-Manuel de Villena, F.; Heise, M. T.; Ferris, M. T.
10.1101/2022.08.30.505889 — genetics — Posted on 2022-09-02
4094 Pulse-Width Modulation of Gene Expression in Budding Yeast
Machne, R.; Murray, D. B.; Bernhart, S. H.; Axmann, I. M.; Stadler, P. F.
10.1101/2021.05.26.444658 — cell biology — Posted on 2022-09-02
4095 IFITM3 blocks viral entry by sorting lipids and stabilizing hemifusion
Klein, S.; Golani, G.; Lolicato, F.; Beyer, D.; Herrmann, A.; Wachsmuth-Melm, M.; Reddmann, N.; Brecht, R.; Lahr, C.; Hosseinzadeh, M.; Kolovou, A.; Schorb, M.; Schwab, Y.; Bruegger, B.; Nickel, W.; Schwarz, U. S.; Chlanda, P.
10.1101/2022.09.01.506185 — molecular biology — Posted on 2022-09-02
4097 The Tramtrack group BTB protein domains are Arthropoda-specific multimerization modules
Bonchuk, A.; Balagurov, K.; Boyko, K.; Sluchanko, N. N.; Khrustaleva, A.; Burtseva, A.; Kuzmina, N.; Arkova, O.; Khalisova, K.; Popov, V.; Georgiev, P.
10.1101/2022.09.01.506177 — molecular biology — Posted on 2022-09-02
4098 ONECUT2 restricts Microfold cell numbers in the small intestine; a multi-omics study
Velez, M. V. L.; Neikes, H. K.; Snabel, R. R.; Quint, Y.; Qian, C.; Martens, A.; Veenstra, G. J. C.; Freeman, M. R.; van Heeringen, S. J.; Vermeulen, M.
10.1101/2022.09.01.506202 — molecular biology — Posted on 2022-09-02
4099 Global characterization of gene expression in the brain of starved immature R. prolixus
Nevoa, J. C.; Estivalis, J. M. L.; Pais, F. S.-M.; Fernandes, G. R.; Lorenzo, M. G.; Guarneri, A. A.
10.1101/2022.09.01.506236 — molecular biology — Posted on 2022-09-02
4100 N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
Varland, S.; Silva, R. D.; Kjosas, I.; Faustino, A.; Bogaert, A.; Billmann, M.; Boukhatmi, H.; Kellen, B.; Costanzo, M.; Drazic, A.; Osberg, C.; Chan, K.; Zhang, X.; Tong, A. H. Y.; Andreazza, S.; Lee, J. J.; Nedyalkova, L.; Usaj, M.; Whitworth, A. J.; Andrews, B. J.; Moffat, J.; Myers, C. L.; Gevaert, K.; Boone, C.; Martinho, R. G.; Arnesen, T.
10.1101/2022.09.01.505523 — molecular biology — Posted on 2022-09-02
4101 Hallucination of closed repeat proteins containing central pockets
An, L.; Hicks, D. R.; Zorine, D.; Dauparas, J.; Wicky, B. I. M.; Milles, L. F.; Courbet, A.; Bera, A. K.; Nguyen, H.; Kang, A.; Carter, L.; Baker, D.
10.1101/2022.09.01.506251 — molecular biology — Posted on 2022-09-02
4102 An Engineered T7 RNA Polymerase for efficient co-transcriptional capping with reduced dsRNA byproducts in mRNA synthesis
Miller, M.; Alvizo, O.; Chng, C.; Jenne, S.; Mayo, M.; Mukherjee, A.; Sundseth, S.; Chinthala, A.; Penfield, J.; Riggins, J.; Zhang, S.; Sero, A.; Dassie, J.; Leatherbury, N.; Baskerville, S.; Huisman, G.
10.1101/2022.09.01.506264 — molecular biology — Posted on 2022-09-02
4106 An Azobenzene G-quadruplex Ligand Exhibits Promising Antibacterial Activity against Escherichia coli
Ramos-Soriano, J.; Takebayashi, Y.; Samphire, J.; O'Hagan, M.; Gurr, C.; Heesom, K. J.; Lewis, P. A.; Spencer, J.; Galan, M. C.
10.1101/2022.09.01.506212 — microbiology — Posted on 2022-09-02
4110 P1 bacteriophage-enabled delivery of CRISPR-Cas9 antimicrobial activity against Shigella flexneri
Huan, Y. W.; Torraca, V.; Brown, R.; Fa-arun, J.; Miles, S. L.; Oyarzun, D. A.; Mostowy, S.; Wang, B.
10.1101/2022.09.02.506314 — microbiology — Posted on 2022-09-02
4111 Phagocytosis via complement receptor 3 enables microbes to evade killing by neutrophils
Smirnov, A.; Daily, K. P.; Gray, M. C.; Ragland, S. A.; Werner, L. M.; Johnson, M. B.; Eby, J. C.; Hewlett, E. L.; Taylor, R. P.; Criss, A. K.
10.1101/2022.09.01.506228 — microbiology — Posted on 2022-09-02
4112 Volatile aroma compound production is affected by growth rate in S. cerevisiae
Visinoni, F.; Zhang, P.; Hollywood, K.; Carlin, S.; Vrhovsek, U.; Winterburn, J.; Delneri, D.
10.1101/2022.09.01.506294 — microbiology — Posted on 2022-09-02
4114 Mucosal and systemic neutralizing antibodies to norovirus and rotavirus by oral immunization with recombinant rotavirus in infant mice
Kawagishi, T.; Sanchez-Tacuba, L.; Feng, N.; Costantini, V. P.; Tan, M.; Jiang, X.; Green, K. Y.; Vinje, J.; Ding, S.; Greenberg, H. B.
10.1101/2022.09.01.505917 — microbiology — Posted on 2022-09-02
4115 Variable effects on virulence of bacteriophage resistance mechanisms in extraintestinal pathogenic Escherichia coli
Gaborieau, B.; Delattre, R.; Adiba, S.; Clermont, O.; Denamur, E.; Ricard, J.-D.; Debarbieux, L.
10.1101/2022.09.01.506217 — microbiology — Posted on 2022-09-02
4119 ZEB2 regulates the development of CD11c+ atypical B cells
Gao, X.; Shen, Q.; Roco, J. A.; Frith, K.; Munier, C. M. L.; Nekrasov, M.; Dalton, B.; He, J.-S.; Jaeger, R.; Cook, M. C.; Zaunders, J. J.; Cockburn, I. A.
10.1101/2022.09.01.506173 — immunology — Posted on 2022-09-02
4121 Phylogenomics reveals the evolutionary origin of lichenization in chlorophyte algae
Puginier, C.; Libourel, C.; Otte, J.; Skaloud, P.; Haon, M.; Grisel, S.; Petersen, M.; Berrin, J.-G.; Delaux, P.-M.; Dal Grande, F.; Keller, J.
10.1101/2022.01.06.475074 — plant biology — Posted on 2022-09-02
4122 CRISPR Mediated Transactivation in the Human Disease Vector Aedes aegypti
Bui, M.; Benetta, E. D.; Dong, Y.; Zhao, Y.; Yang, T.; Li, M.; Antoshechkin, I. A.; Buchman, A.; Bottino-Rojas, V.; James, A. A.; Perry, M. W.; Dimopoulos, G.; Akbari, O.
10.1101/2022.08.31.505972 — bioengineering — Posted on 2022-09-02
4123 Opposite regulation of glycogen metabolism by cAMP produced in the cytosol and at the plasma membrane
Verhoeven, A. J.; Bizerra, P. F. V.; Gilglioni, E. H.; Go, S.; Li, H. L.; Elferink, R. P. J. O.; Chang, J.-C.
10.1101/2022.09.01.505928 — biochemistry — Posted on 2022-09-02
4124 Lipid Desaturation Regulates the Balance between Self-renewal and Differentiation in Mouse Blastocyst-derived Stem Cells
Thomas, C.; Haimson, R. B.; Zacharia, A.; Orih, P.; Shehadeh, A.; Saidemberg, D.; Kogan, N. M.; Alfandary, S.; Serruya, R.; Dagan, A.; Petit, I.; Moussaieff, A.
10.1101/2022.07.28.501839 — developmental biology — Posted on 2022-09-02
4131 LGR5 targeting molecules as therapeutic agents for multiple cancer types
Chen, H.-C.; Mueller, N.; Stott, K.; Rivers, E.; Kapeni, C.; Sauer, C. M.; Beke, F.; Walsh, S.; Ashman, N.; O'Brien, L. M.; Fard, A. R.; Godsinia, A.; Joud, F.; Giger, O.; Zlobec, I.; Olan, I.; Aitken, S. J.; Hoare, M.; Mair, R.; Serrao, E.; Brenton, J. D.; Garcia-Gimenez, A.; Richardson, S. E.; Huntly, B.; Spring, D. R.; Skjodt, M.-O.; Skjodt, K.; de la Roche, M.; de la Roche, M.
10.1101/2022.09.01.506182 — cell biology — Posted on 2022-09-02
4132 MMD scaffolds ACSL4 and MBOAT7 to promote polyunsaturated phospholipid synthesis and susceptibility to ferroptosis
Phadnis, V. V.; Snider, J.; Wong, V.; Vaccaro, K. D.; Kunchok, T.; Allen, J.; Yao, Z.; Geng, B.; Weiskopf, K.; Stagljar, I.; Henry, W. S.; Weinberg, R. A.
10.1101/2022.09.01.506096 — cell biology — Posted on 2022-09-02
4133 Preventing Jacob-induced transcriptional inactivation of CREB protects synapses from β-amyloid in Alzheimer's Disease
Grochowska, K. M.; Gomes, G. M.; Raman, R.; Kaushik, R.; Sosulina, L.; Kaneko, H.; Oelschlegel, A. M.; Yuanxiang, P.; Reyes-Resina, I.; Bayraktar, G.; Samer, S.; Spilker, C.; Woo, M. S.; Morawski, M.; Goldschmidt, J.; Friese, M. A.; Rossner, S.; Navarro Brugal, G.; Remy, S.; Reissner, C.; Karpova, A.; Kreutz, M. R.
10.1101/2020.01.08.898304 — neuroscience — Posted on 2022-09-02
4137 Structural insights into regulation of the PEAK3 scaffold by 14-3-3
Torosyan, H.; Paul, M. D.; Forget, A.; Lo, M.; Diwanji, D.; Pawlowski, K.; Krogan, N. J.; Jura, N.; Verba, K. A.
10.1101/2022.09.01.506268 — biophysics — Posted on 2022-09-02
4138 Solid-State Single-Molecule Sensing with the Electronic Life-detection Instrument for Enceladus/Europa (ELIE)
Carr, C. E.; Ramirez-Colon, J. L.; Duzdevich, D. E.; Lee, S.; Taniguchi, M.; Ohshiro, T.; Komoto, Y.; Soderblom, J. M.; Zuber, M. T.
10.1101/2022.08.31.505913 — biophysics — Posted on 2022-09-02
4139 Markov State Modelling Reveals Heterogeneous Drug-Inhibition Mechanism of Calmodulin
Westerlund, A. M.; Sridhar, A.; Dahl, L.; Andersson, A.; Bodnar, A.-Y.; Delemotte, L.
10.1101/2022.06.08.495419 — biophysics — Posted on 2022-09-02
4142 Nuclear-enriched protein phosphatase 4 ensures outer kinetochore assemblyprior to nuclear dissolution
Rocha, H.; Simoes, P. A.; Budrewicz, J.; Lara-Gonzalez, P.; Xavier de Carvalho, A.; Dumont, J.; Desai, A.; Gassmann, R.
10.1101/2022.09.01.505886 — cell biology — Posted on 2022-09-02
4143 Human cellular model systems of β-thalassemia enablein-depth analysis of disease phenotype
Daniels, D. E.; Ferrer-Vicens, I.; Hawksworth, J.; Andrienko, T. N.; Finnie, E. M.; Ferguson, D. C. J.; Oliveira, A. S. F.; Szeto, J.-Y. A.; Wilson, M. C.; Frayne, J.
10.1101/2022.09.01.506225 — cell biology — Posted on 2022-09-02
4145 Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast
Shen, Y.; Gao, F.; Wang, Y.; Wang, Y.; Zheng, J.; Gong, J.; Zhang, J.; Luo, Z.-Q.; Schindler, D.; Deng, Y.; Ding, W.; Lin, T.; Swidah, R.; Zhao, H.; Jiang, S.; Chen, S.; Chen, T.; Wang, Y.; Luo, Y.; Mitchell, L. A.; Bader, J.; Zhang, G.; Shen, X.; Wang, J.; Fu, X.; Dai, J.; Boeke, J. D.; Yang, H. D.; Xu, X.; Cai, Y.
10.1101/2022.09.01.506252 — synthetic biology — Posted on 2022-09-02
4147 Cancer-Associated Mutations Enhance The Sensitivity Of The Trupath GαQ/11 System
Safitri, D.; Harris, M.; Pearce, A.; Huang, X.; Rosa, M.; Barkan, K.; Wills, E.; Marti-Solano, M.; Falk, M.; Ladds, G.
10.1101/2022.09.01.506210 — pharmacology and toxicology — Posted on 2022-09-02
4151 A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus
Placzek, M.; Chinnaiya, K.; Burbridge, S.; Jones, A.; Kim, D. W.; Place, E.; Manning, E.; Groves, I.; Sun, C.; Towers, M.; Blackshaw, S.
10.1101/2022.08.31.506043 — developmental biology — Posted on 2022-09-02
4152 Duplicated zebrafish (Danio rerio) inositol phosphatases inpp5ka and inpp5kb diverged in expression pattern and function
Shukla, D.; Gural, B. M.; Cauley, E. S.; Roberts, L. E.; Karas, B. F.; Cavallo, L.; Turkalj, L.; Moody, S. A.; Swan, L. E.; Manzini, M. C.
10.1101/2022.08.31.506059 — developmental biology — Posted on 2022-09-02
4153 Distinct features in fish Bouncer proteins determine sperm-egg compatibility
Gert, K. R. B.; Panser, K.; Surm, J. M.; Steinmetz, B.; Schleiffer, A.; Moran, Y.; Kondrashov, F.; Pauli, A.
10.1101/2022.09.01.506233 — developmental biology — Posted on 2022-09-02
4154 Specific sensory neurons and insulin-like peptides modulate food type-dependent oogenesis and fertilization in Caenorhabditis elegans
Mishra, S.; Marbach, K.; Dabaja, M.; Akhlaq, A.; Rovcanin, M.; Pereira, B.; Chandra, R.; Caballero, A.; de Abreu, D. F.; Ch'ng, Q.; Alcedo, J.
10.1101/2022.08.31.506073 — developmental biology — Posted on 2022-09-02
4155 Aneuploidy triggers autophagy and p53-mediated apoptosis and impairs second lineage segregation in human preimplantation embryos
Regin, M.; Lei, Y.; De Deckersberg, E. C.; Guns, Y.; Verdyck, P.; Verheyen, G.; Van de Velde, H.; Sermon, K.; Spits, C.
10.1101/2022.08.31.506009 — developmental biology — Posted on 2022-09-02
4158 Cellular senescence modulates progenitor cell expansion during axolotl limb regeneration
Yu, Q.; Walters, H.; Pasquini, G.; Singh, S. P.; Perinan, D. L.; Petzold, A.; Kesavan, P.; Subiran, C.; Suner, I. G.; Knapp, D.; Wagner, A.; Bernardos, A.; Alfonso, M.; Nadar, G.; Dahl, A.; Busskamp, V.; Manaez, R.; Yun, M.
10.1101/2022.09.01.506196 — developmental biology — Posted on 2022-09-02
4160 Multimodal Object Representations Rely on Integrative Coding
Li, A. Y.; Ladyka-Wojcik, N.; Qazilbash, H.; Golestani, A.; Walther, D. B.; Martin, C. B.; Barense, M. D.
10.1101/2022.08.31.504599 — neuroscience — Posted on 2022-09-01
4167 A cross-species study of sex chromosome dosage effects on mammalian brain anatomy
Guma, E.; Beauchamp, A.; Liu, S.; Levitis, E.; Clasen, L. S.; Torres, E.; Blumenthal, J.; Lalonde, F.; Qiu, L. R.; Hrncir, H.; MacKenzie-Graham, A. J.; Yang, X.; Arnold, A. P.; Lerch, J. P.; Raznahan, A.
10.1101/2022.08.30.505916 — neuroscience — Posted on 2022-09-01
4168 OPT3 Transports Copper to the Phloem, Mediates Shoot-to-Root Copper Signaling andCrosstalk Between Copper and Iron Homeostasis in A. thaliana
Vatamaniuk, O. K.; Chia, J.-C.; Yan, J.; Rahmati Ishka, M.; Faulkner, M. M.; Simons, E.; Huang, R.; Smieska, L. M.; Woll, A. R.; Tappero, R. V.; Kiss, A.; Jiao, C.; Fei, Z.; Pineros, M. A.; Kochian, L. V.; Walker, E. L.
10.1101/2021.07.30.454504 — plant biology — Posted on 2022-09-01
4172 Concordance of MERFISH Spatial Transcriptomics with Bulk and Single-cell RNA Sequencing
Liu, J.; Tran, V.; Vemuri, V. N. P.; Byrne, A.; Borja, M.; Kim, Y. J.; Agarwal, S.; Wang, R.; Awayan, K.; Murti, A.; Taychameekiatchai, A.; Wang, B.; Emanuel, G.; He, J.; Haliburton, J.; Pisco, A. O.; Neff, N.
10.1101/2022.03.04.483068 — bioinformatics — Posted on 2022-09-01
4174 A low-cost, open-source evolutionary bioreactor and its educational use
Gopalakrishnan, V.; Crozier, D.; Card, K.; Chick, L.; Krishnan, N. P.; McClure, E.; Pelesko, J.; Williamson, D. F. K.; Nichol, D.; Mandal, S.; Bonomo, R. A.; Scott, J. G.
10.1101/729434 — bioengineering — Posted on 2022-09-01
4178 Environmental niche and demographic modeling of American chestnut near its southwestern range limit
Laport, R. G.; Brookover, Z. S.; Christman, B. D.; Ng, J.; Philley, K.; Craddock, J. H.
10.1101/2021.09.10.459451 — ecology — Posted on 2022-09-01
4185 Global Phylogeny of the Brassicaceae Provides Important Insights into Gene Discordance
Hendriks, K. P.; Kiefer, C.; Al-Shehbaz, I. A.; Bailey, C. D.; Hooft van Huysduynen, A. A. C.; Nikolov, L.; Nauheimer, L.; Zuntini, A. R.; German, D. A.; Franzke, A.; Koch, M. A.; Lysak, M. A.; Toro-Nunez, O.; Ozudogru, B.; Invernon, V. R.; Walden, N.; Maurin, O.; Hay, N.; Sushkov, P.; Mandakova, T.; Thulin, M.; Windham, M.; Resetnik, I.; Spaniel, S.; Ly, E.; Pires, J. C.; Harkess, A.; Neuffer, B.; Vogt, R.; Braeuchler, C.; Rainer, H.; Janssens, S.; Schmull, M.; Forrest, A.; Guggisberg, A.; Zmarzty, S.; Lepschi, B.; Scarlett, N.; Stauffer, F. W.; Schonberger, I.; Heenan, P.; Baker, W. J.; Fore
10.1101/2022.09.01.506188 — evolutionary biology — Posted on 2022-09-01
4187 gUMI-BEAR, a modular, unsupervised population barcoding method to track variants and evolution at high resolution
Rezenman, S.; Knafo, M.; Tsigalnitski, I.; Barad, S.; Jona, G.; Levi, D.; Dym, O.; Reich, Z.; kapon, r.
10.1101/2022.09.01.506035 — evolutionary biology — Posted on 2022-09-01
4189 Snip1 and PRC2 coordinate intrinsic apoptosis, cell division, and neurogenesis in the developing brain
Matsui, Y.; Djekidel, M. N.; Lindsay, K.; Samir, P.; Connolly, N.; Chen, H.; Fan, Y.; Xu, B.; Peng, J. C.
10.1101/2022.04.27.489801 — developmental biology — Posted on 2022-09-01
4193 Regulation of prostate androgens by megalin and 25-hydroxyvitamin D status: Mechanism for high prostate androgen in African American men
Garcia, J.; Krieger, K.; Loitz, C.; Perez, L. M.; Richards, Z. A.; Helou, Y. B.; Kregel, S.; Selada, S.; Mesaros, C. A.; Gann, P.; Willnow, T. E.; Vander Griend, D.; Kittles, R.; Prins, G.; Penning, T.; Nonn, L.
10.1101/2021.11.09.467567 — cancer biology — Posted on 2022-09-01
4194 SARS-CoV-2 Omicron BA.2.75 variant may be much more infective than preexisting variants
Sugano, A.; Takaoka, Y.; Kataguchi, H.; Kumaoka, M.; Ohta, M.; Kimura, S.; Araki, M.; Morinaga, Y.; Yamamoto, Y.
10.1101/2022.08.25.505217 — bioinformatics — Posted on 2022-09-01
4195 Structural basis of nirmatrelvir and ensitrelvir resistance profiles against SARS-CoV-2 Main Protease naturally occurring polymorphisms
Noske, G. D.; Silva, E. S.; Godoy, M. O.; Dolci, I.; Fernandes, R. S.; Guido, R. V. C.; Sjo, P.; Oliva, G.; Godoy, A. S.
10.1101/2022.08.31.506107 — biochemistry — Posted on 2022-09-01
4198 Laboratory rearing alters activity and sleep patterns in the olive fruit fly
Terzidou, A. M.; Koveos, D. S.; Papadopoulos, N. T.; Carey, J. R.; Kouloussis, N. A.
10.1101/2022.08.31.506115 — animal behavior and cognition — Posted on 2022-09-01
4199 Multi-tissue landscape of somatic mtDNA mutations indicates tissue specific accumulation and removal in aging
Sanchez-Contreras, M.; Sweetwyne, M. T.; Tsantilas, K. A.; Whitson, J. A.; Campbell, M. D.; Kohrn, B. F.; Kim, H.-J.; Fredrickson, J.; Nguyen, M. M.; Hurley, J. B.; Marcinek, D. J.; Rabinovitch, P. S.; Kennedy, S. R.
10.1101/2022.08.30.505884 — genomics — Posted on 2022-09-01
4200 Mapping mitonuclear epistasis using a novel recombinant yeast population
Nguyen, T. H. M.; Tinz-Burdick, A.; Lenhardt, M.; Geertz, M.; Ramirez, F.; Schwartz, M.; Toledano, M.; Bonney, B.; Gaebler, B.; Liu, W.; Wolters, J. F.; Chiu, K.; Fiumera, A. C.; Fiumera, H.
10.1101/2022.08.31.505974 — evolutionary biology — Posted on 2022-09-01
4202 Genetic control of RNA editing in Neurodegenerative disease
Wu, S.; Xue, Q.; Yang, M.; Wang, Y.; Kim, P.; zhou, X.; Huang, L.
10.1101/2022.08.31.505995 — bioinformatics — Posted on 2022-09-01
4203 Factors influencing patterns of gene expression in large bowel mucosa
Vaughan-Shaw, P.; Ooi, L.; Timofeeva, M.; Grimes, G.; Din, F. V.; Farrington, S. M.; Dunlop, M. G.
10.1101/2022.08.30.505238 — genomics — Posted on 2022-09-01
4208 NF-κB Decoy ODN-Loaded Poly lactic-co-glycolic Acid Nanospheres Inhibit Alveolar Ridge Resorption
Huang, A. C. S.; Ishida, Y.; Li, K.; Rintanalert, D.; Hatano-sato, K.; Oishi, S.; Hosomichi, J.; Usumi-Fujita, R.; Yamaguchi, H.; Tsujimoto, H.; Sasai, A.; Ochi, A.; Watanabe, H.; Ono, T.
10.1101/2022.08.30.505814 — immunology — Posted on 2022-09-01
4210 Walk the Plank! Using mobile EEG to investigate emotional lateralization of immersive fear in virtual reality
Basbasse, Y.; Packheiser, J.; Peterburs, J.; Maymon, C.; Guentuerkuen, O.; Grimshaw, G.; Ocklenburg, S.
10.1101/2022.08.30.505699 — neuroscience — Posted on 2022-09-01
4213 Improving fMRI in Parkinson's Disease by Accounting for Brain Region-Specific Activity Patterns
Torrecuso, R.; Mueller, K.; Sieger, T.; Vymazal, J.; Ruzicka, F.; Roth, J.; Ruzicka, E.; Schroeter, M. L.; Jech, R.; Möller, H. E.
10.1101/2022.08.30.505786 — neuroscience — Posted on 2022-09-01
4216 Cardiac pericytes are necessary for coronary vasculature integrity and cardiomyocyte differentiation
Cornuault, L.; Herion, F.-X.; Rouault, P.; Foussard, N.; Alzieu, P.; Chapouly, C.; Gadeau, A.-P.; Couffinhal, T.; Renault, M.-A.
10.1101/2022.08.29.505703 — physiology — Posted on 2022-09-01
4218 Automatic Sample Segmentation & Detection of Parkinson's Disease Using Synthetic Staining & Deep Learning
Pearce, B. M.; Coetzee, P. L.; Rowland, D.; Dexter, D. T.; Gveric, D. O.; Gentleman, S.
10.1101/2022.08.30.505459 — pathology — Posted on 2022-09-01
4220 Evolutionary states and trajectories characterized by distinct pathways stratify ovarian high-grade serous carcinoma patients
Lahtinen, A.; Lavikka, K.; Li, Y.; Virtanen, A.; Jamalzadeh, S.; Huhtinen, K.; Carpen, O.; Hietanen, S.; Häkkinen, A.; Hynninen, J.; Oikkonen, J.; Hautaniemi, S.
10.1101/2022.08.30.505808 — cancer biology — Posted on 2022-09-01
4227 New algorithms for accurate and efficient de-novo genome assembly from long DNA sequencing reads
Gonzalez-Garcia, L. N.; Guevara-Barrientos, D.; Lozano-Arce, D.; Gil, J.; Diaz-Riano, J.; Duarte, E.; Andrade, G.; Bojaca, J. C.; Hoyos, M. C.; Chavarro, C.; Guayazan, N.; Chica, L. A.; Buitrago Acosta, M. C.; Bautista, E.; Trujillo, M.; Duitama, J.
10.1101/2022.08.30.505891 — bioinformatics — Posted on 2022-09-01
4231 A red fluorescent genetically encoded biosensor for extracellular L-lactate
Nasu, Y.; Kamijo, Y.; Hashizume, R.; Sato, H.; Hori, Y.; Tomita, T.; Drobizhev, M.; Campbell, R. E.
10.1101/2022.08.30.505811 — bioengineering — Posted on 2022-09-01
4233 Mesenchymal stem cell culture within perfusion bioreactors incorporating 3D-printed scaffolds enables improved extracellular vesicle yield with preserved bioactivity
Kronstadt, S. M.; Patel, D. B.; Born, L. J.; Levy, D.; Lerman, M. J.; Mahadik, B.; McLoughlin, S. T.; Fasuyi, A.; Fowlkes, L.; Hoorens van Heyningen, L.; Aranda, A.; Abadchi, S. N.; Chang, K.-H.; Hsu, A. T. W.; Bengali, S.; Harmon, J. W.; Fisher, J. P.; Jay, S. M.
10.1101/2022.08.30.505860 — bioengineering — Posted on 2022-09-01
4234 Mera: A scalable high throughput automated micro-physiological system
Cliffe, F.; Costello, P.; Madden, C.; Devitt, S.; Mukkunda, S. R.; Keshava, B. B.; Fearnhead, H.; Vitkuaskaite, A.; Dehkordi, M.; Chingwaru, W.; Przyjalgowski, M.; Rebrova, N.; Lyons, M.
10.1101/2022.08.30.505827 — bioengineering — Posted on 2022-09-01
4236 Relictual Hybridization and Biogeography of Massasauga Rattlesnakes (Sistrurus spp.)
Martin, B. T.; Douglas, M. R.; Chafin, T. K.; Placyk, J. S.; Mackessy, S. P.; Briggler, J. T.; Douglas, M. E.
10.1101/2022.08.29.505772 — evolutionary biology — Posted on 2022-09-01
4242 LSD-induced increase of Ising temperature and algorithmic complexity of brain dynamics
Ruffini, G.; Damiani, G.; Lozano-Soldevilla, D.; Deco, N.; Rosas, F.; Kiani, N.; Ponce-Alvarez, A.; Kringelbach, M. L.; Carhart-Harris, R.; Deco, G. L.
10.1101/2022.08.27.505518 — neuroscience — Posted on 2022-09-01
4244 PEZO-1 and TRP-4 mechanosensors are involved in mating behavior in Caenorhabditis elegans
Brugman, K. I.; Susoy, V.; Whittaker, A. J.; Palma, W.; Nava, S.; Samuel, A. D.; Sternberg, P. W.
10.1101/2022.08.31.506045 — neuroscience — Posted on 2022-09-01
4246 Silencing long-descending inter-enlargement propriospinal neurons improves hindlimb stepping after contusive spinal cord injuries
Shepard, C. T.; Brown, B. L.; Van Rijswijck, M. A.; Zalla, R. M.; Burke, D. A.; Morehouse, J. R.; Riegler, A. S.; Whittemore, S. R.; Magnuson, D. S.
10.1101/2022.08.30.505848 — neuroscience — Posted on 2022-09-01
4248 Boolean modeling of mechanosensitive Epithelial to Mesenchymal Transition and its reversal
Sullivan, E.; Harris, M.; Bhatnagar, A.; Guberman, E.; Zonfa, I.; Ravasz Regan, E.
10.1101/2022.08.29.505701 — systems biology — Posted on 2022-09-01
4250 Mapping the adaptor protein complex interaction network in Arabidopsis identifies P34 as a common stability regulator
Wang, P.; Siao, W.; Zhao, X.; Arora, D.; Wang, R.; Eeckhout, D.; Van Leene, J.; Kumar, R.; Houbaert, A.; De Winne, N.; Mylle, E.; Vandorpe, M.; Korver, R. A.; Testerink, C.; Gevaert, K.; Vanneste, S.; De Jaeger, G.; Van Damme, D.; Russinova, E.
10.1101/2022.08.31.505729 — plant biology — Posted on 2022-09-01
4253 X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction
Zhang, P.; Munier, J. J.; Vergnes, L.; Wiese, C. B.; Link, J. C.; Abbasi, F.; Ronquillo, E.; Munoz, A.; Kuang, Y.-L.; Liu, M.; Sanchez, G.; Oni-Orisan, A.; Iribarren, C.; McPhaul, M. J.; Nomura, D. K.; Knowles, J. W.; Krauss, R. M.; Medina, M. W.; Reue, K.
10.1101/2022.08.29.505759 — physiology — Posted on 2022-09-01
4258 Effective root responses to salinity stress include maintained cell expansion and carbon allocation
Li, H.; Duijts, K.; Pasini, C.; van Santen, J. E.; Wang, N.; Zeeman, S. C.; Santelia, D.; Zhang, Y.; Testerink, C.
10.1101/2022.09.01.506200 — plant biology — Posted on 2022-09-01
4260 A low-cost, open-source evolutionary bioreactor and its educational use
Gopalakrishnan, V.; Guo, D.; Card, K.; Chick, L.; Krishnan, N. P.; McClure, E.; Pelesko, J.; Williamson, D. F. K.; Nichol, D.; Mandal, S.; Bonomo, R. A.; Scott, J. G.
10.1101/729434 — bioengineering — Posted on 2022-09-01
4261 Spatial Transcriptomics Using Multiplexed Deterministic Barcoding in Tissue
Wirth, J.; Compera, N.; Yin, K.; Brood, S.; Chang, S.; Martinez-Jimenez, C. P.; Meier, M.
10.1101/2022.08.30.505834 — genomics — Posted on 2022-09-01
4262 Nucleotide and structural polymorphisms of the eastern oyster genome paint a mosaic of divergence, selection, and human impacts
Puritz, J. B.; Zhao, H.; Guo, X.; Hare, M. P.; He, Y.; LaPeyre, J.; Lotterhos, K. E.; Lundgren, K. M.; Modak, T.; Proestou, D. A.; Rawson, P.; Fernandez Robledo, J. A.; Witkop, E.; Weedop, K. B.; Gomez-Chiarri, M.
10.1101/2022.08.29.505629 — evolutionary biology — Posted on 2022-09-01
4265 Physical association of low density lipoprotein particles and extracellular vesicles unveiled by single particle analysis
Lozano-Andres, E.; Enciso-Martinez, A.; Gijsbers, A.; Libregts, S. F. W. M.; Pinheiro, C.; van Niel, G.; Hendrix, A.; Peters, P. J.; Otto, C.; Arkesteijn, G. J. A.; Wauben, M.
10.1101/2022.08.31.506022 — cell biology — Posted on 2022-09-01
4266 Myoglobin promotes cardiomyocyte differentiation through oxidatively modulating the Hippo Kinase Pathway
Rao, K.; Rochon, E.; Singh, A.; Jagnnathan, R.; Peng, Z.; Moulik, M.; Zhang, M.; Corti, P.; Shiva, S.
10.1101/2022.08.31.506050 — cell biology — Posted on 2022-09-01
4267 Molecular regulation of GPCR-G-protein-governed PIP3 generation and its adaptation
Wijayaratna, D.; Ratnayake, K.; Ubeysinghe, S.; Kankanamge, D.; Tennakoon, M.; Karunarathne, A.
10.1101/2022.08.31.506078 — cell biology — Posted on 2022-09-01
4268 mTOR pathway inhibition stimulates pharmacologically induced nonsense suppression
Wittenstein, A.; Caspi, M.; Rippin, I.; Elroy-Stein, O.; Eldar-Finkelmn, H.; Thoms, S.; Rosin-Arbesfeld, R.
10.1101/2022.08.31.506003 — cell biology — Posted on 2022-09-01
4271 SARS-CoV-2 Omicron BA.2.75 variant may be much more infective than preexisting variants
Sugano, A.; Takaoka, Y.; Kataguchi, H.; Kumaoka, M.; Ohta, M.; Kimura, S.; Araki, M.; Morinaga, Y.; Yamamoto, Y.
10.1101/2022.08.25.505217 — bioinformatics — Posted on 2022-09-01
4272 Impact of reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters
Shiwa-Sudo, N.; Sakai, Y.; Iwata-Yoshikawa, N.; Watanabe, S.; Yamada, S.; Kuroda, Y.; Yamamoto, T.; Shirakura, M.; Fujisaki, S.; Miyazaki, K.; Miura, H.; Nagata, S.; Fukushi, S.; Maeda, K.; Hasegawa, H.; Suzuki, T.; Nagata, N.
10.1101/2022.08.30.505966 — microbiology — Posted on 2022-09-01
4275 Cleavage of 14-3-3ϵ by the enteroviral 3C protease dampens RIG-I mediated antiviral signaling
Andrews, D. D.; Mohamud, Y.; Vlok, M.; Akbari Bani, D.; Hay, B. N.; Foster, L. J.; Luo, H.; Overall, C. M.; Jan, E.
10.1101/2022.08.31.505975 — microbiology — Posted on 2022-09-01
4276 Lateral line hair cells integrate mechanical and chemical cues to orient navigation
Desban, L.; Roussel, J.; Mirat, O.; Lejeune, F.-X.; Keiser, L.; Michalski, N. A.; Wyart, C.
10.1101/2022.08.31.505989 — neuroscience — Posted on 2022-09-01
4277 Quantification of Monosynaptic Rabies Tracing Efficiency
Patino, M.; Lagos, W. N.; Patne, N. S.; Miyazaki, P. A.; Callaway, E.
10.1101/2022.08.31.506012 — neuroscience — Posted on 2022-09-01
4278 An electrophysiological and kinematic model of Paramecium, the "swimming neuron"
Elices, I.; Kulkarni, A.; Escoubet, N.; Pontani, L.-L.; Prevost, A. M.; Brette, R.
10.1101/2022.02.15.480485 — neuroscience — Posted on 2022-09-01
4283 MATEdb, a data repository of high-quality metazoan transcriptome assemblies to accelerate phylogenomic studies
Fernandez, R.; Tonzo, V.; Simon Guerrero, C.; Lozano-Fernandez, J.; Martinez-Redondo, G. I.; Balart-Garcia, P.; Aristide, L.; Eleftheriadi, K.; Vargas-Chavez, C.
10.1101/2022.07.18.500182 — evolutionary biology — Posted on 2022-09-01
4284 Fragmented habitat compensates for the adverse effects of genetic bottleneck
Löytynoja, A.; Rastas, P.; Valtonen, M.; Kammonen, J.; Holm, L.; Tange Olsen, M.; Paulin, L.; Jernvall, J.; Auvinen, P.
10.1101/2022.04.05.487133 — evolutionary biology — Posted on 2022-09-01