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Archive, 2024-04

8 Genome-wide association for loci influencing thermal performance curves in Neurospora crassa
Rasanen, E.; Moghadam, N. N.; Sidhu, K.; Summanen, P. A. M.; Littunen, H.-R.; Ketola, T.; Kronholm, I.
10.1101/2024.04.29.591604 — genetics — Posted on 2024-04-30
9 Developmental origins and evolution of pallial cell types and structures in birds
Zaremba, B.; Fallahshahroudi, A.; Schneider, C.; Schmidt, J.; Sarropoulos, I.; Leushkin, E.; Berki, B.; Van Poucke, E.; Jensen, P.; Senovilla-Ganzo, R.; Hervas-Sotomayor, F.; Trost, N.; Lamanna, F.; Sepp, M.; Garcia-Moreno, F.; Kaessmann, H.
10.1101/2024.04.30.591857 — evolutionary biology — Posted on 2024-04-30
10 Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny
Hunt, M.; Hinrichs, A. S.; Anderson, D.; Karim, L.; Dearlove, B. L.; Knaggs, J.; Constantinides, B.; Fowler, P. W.; Rodger, G.; Street, T. L.; Lumley, S. F.; Webster, H.; Sanderson, T.; Ruis, C.; De Maio, N.; Amenga-Etego, L. N.; Amuzu, D. S.; Avaro, M.; Awandare, G. A.; Ayivor-Djanie, R.; Bashton, M.; Batty, E. M.; Bediako, Y.; De Belder, D.; Benedetti, E.; Bergthaler, A.; Boers, S. A.; Campos, J.; Carr, R. A. A.; Cuba, F.; Dattero, M. E.; Dejnirattisai, W.; Dilthey, A. T.; Duedu, K. O.; Endler, L.; Engelmann, I.; Francisco, N. M.; Fuchs, J.; Gnimpieba Z., E.; Groc, S.; Gyamfi, J.; Heemskerk,
10.1101/2024.04.29.591666 — bioinformatics — Posted on 2024-04-30
12 Annotation of DOM Metabolomes with an Ultrahigh Resolution Mass Spectrometry Molecular Formula Library
Coffey, N. R.; Dewey, C.; Manning, K.; Corilo, Y.; Kew, W.; Babcock-Adams, L.; McKenna, A. M.; Stuart, R. K.; Boiteau, R. M.
10.1101/2024.04.30.591926 — molecular biology — Posted on 2024-04-30
13 Discovery and Quantification of Long-Range RNA Base Pairs in Coronavirus Genomes with SEARCH-MaP and SEISMIC-RNA
Allan, M. F.; Aruda, J.; Plung, J. S.; Grote, S. L.; Martin, Y. J.; de Lajarte, A. A.; Bathe, M.; Rouskin, S.
10.1101/2024.04.29.591762 — molecular biology — Posted on 2024-04-30
17 Tau filaments with the Alzheimer fold in cases with MAPT mutations V337M and R406W
Qi, C.; Lovestam, S.; Murzin, A. G.; Peak-Chew, S.; Franco, C.; Bogdani, M.; Latimer, C.; Murrell, J. R.; Cullinane, P. W.; Jaunmuktane, Z.; Bird, T. D.; Ghetti, B.; Scheres, S. H. W.; Goedert, M.
10.1101/2024.04.29.591661 — biophysics — Posted on 2024-04-30
20 Molecular basis for plasma membrane recruitment of PI4KA by EFR3
Suresh, S.; Shaw, A. L.; Pemberton, J. G.; Scott, M. K.; Harris, N. J.; Parson, M. A.; Jenkins, M. L.; Rohilla, P.; Prats, A. A.; Balla, T.; Yip, C. K.; Burke, J. E.
10.1101/2024.04.30.587787 — biochemistry — Posted on 2024-04-30
22 Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
Eapen, R.; Okoye, C.; Stubbs, C.; Schimpl, M.; Tischer, T.; McCall, E.; Zacharopoulou, M.; Ferrer, F.; Barford, D.; Spring, D.; Lindon, C.; Phillips, C.; Itzhaki, L. S.
10.1101/2024.04.30.590460 — biochemistry — Posted on 2024-04-30
23 On the function of TRAP substrate-binding proteins: conformational variation of the sialic acid binding protein SiaP
King-Hudson, T.-R. J.; Davies, J. S.; Quan, S.; Currie, M.; Tillett, Z. D.; Copping, J.; Panjikar, S.; Friemann, R.; Allison, J. R.; North, R. A.; Dobson, R.
10.1101/2024.04.30.591957 — biochemistry — Posted on 2024-04-30
27 Late killing of Plasmodium berghei in the liver by an anti-circumsporozoite protein monoclonal antibody
Aguirre-Botero, M. C.; Pacios, O.; Celli, S.; Aliprandini, E.; Gladston, A.; Thiberge, J.-M.; Formaglio, P.; Amino, R.
10.1101/2024.04.30.591864 — microbiology — Posted on 2024-04-30
28 Altered DNA methylation pattern contributes to differential epigenetic immune signaling in the upper respiratory airway of COVID-19 patients
Govender, M.; Das, J.; Hopkins, F. R.; Svanberg, C.; Nordgren, J.; Hagbom, M.; Klingstrom, J.; Nilsdotter-Augustinsson, A.; Yong, Y. K.; Velu, V.; Raju, S.; Sjowall, J.; Shankar, E. M.; Nystrom, S.; Larsson, M.
10.1101/2024.04.29.591494 — microbiology — Posted on 2024-04-30
29 A system for functional studies of the major virulence factor of malaria parasites
Cronshagen, J.; Allweier, J.; Mesen-Ramirez, P.; Staecker, J.; Vaaben, A. V.; Ramon-Zamorano, G.; Naranjo, I.; Ofori, S.; Jansen, P. W.; Hornebeck, J.; Kieferle, F.; Murk, A.; Martin, E.; Castro-Pena, C.; Bartfai, R.; Lavstsen, T.; Bruchhaus, I.; Spielmann, T.
10.1101/2024.04.30.591946 — microbiology — Posted on 2024-04-30
30 Highly Multiplexed Proteomic Analysis of HCMV-Infected Dendritic Cells Reveals Global Manipulation of Adaptive Immunity and Host Restriction of Viral Replication
Kerr-Jones, L.; Soday, L.; Cwyfan-Hughes, N.; Wang, X.; Hunter, L.; Antrobus, R.; Miners, K.; Ladell, K.; Price, D. A.; Fielding, C. A.; Wang, E. C.; Weekes, M. P.; Stanton, R. J.
10.1101/2024.04.30.591855 — microbiology — Posted on 2024-04-30
31 The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis
Wall, E. C.; Guerra-Assuncao, J.-A.; Yang, M.; Konig, R.; Audshasai, T.; Proust, A.; Aprianto, R.; Ramos-Sevillano, E.; Ercoli, G.; Bordin, N.; Agostinho-Terra, V. S.; Veening, J.-W.; Lalloo, D. G.; Wren, B. W.; Wilkinson, R. J.; Brouwer, M. C.; van de Beek, D.; Kadiloglu, A.; Heyderman, R. S.; Brown, J. S.
10.1101/2024.04.30.591261 — microbiology — Posted on 2024-04-30
32 Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosis
Gleiberman, A.; Invernizzi, R.; Molyneaux, P. L.; Wu, B. G.; Lipinski, Y.; Kugler, M.; Segal, L. N.; Sakamachi, Y.; Wiley, E.; Solis, A.; Johnson, C. G.; Meng, X.; Malphurs, J.; Papas, B.; Mehta, S.; Trempus, C. S.; Thomas, S. Y.; Li, J.-L.; Zhou, L.; karmaus, P. W.; Fessler, M. B.; Garantziotis, S.; Randall, T.; Hussain, S.; Gudkov, A. V.; McGrath, J. A.; Walts, A.; Yang, I. V.; Schwartz, D. A.; Lipinski, J. H.; O'Dwyer, D. N.; Gibson, K.; Kass, D. J.; Zhang, Y.; Kaminski, N.
10.1101/2024.04.30.591719 — immunology — Posted on 2024-04-30
34 Darwinian Evolution of Self-Replicating DNA in a Synthetic Protocell
Danelon, C.; Abil, Z.; Restrepo Sierra, A. M.; Stan, A. R.; Chane, A.; del Prado, A.; de Vega, M.; Rondelez, Y.
10.1101/2024.04.30.591827 — synthetic biology — Posted on 2024-04-30
36 Venom-inspired somatostatin receptor 4 (SSTR4) agonists as new drug leads for peripheral pain conditions
Bjorn-Yoshimoto, W. E.; Ramiro, I. B. L.; Koch, T. L.; Engholm, E.; Yeung, H. Y.; Sorensen, K. K.; Goddard, C. M.; Jensen, K. L.; Smith, N. A. A.; Martin, L. F.; Smith, B. J.; Madsen, K. L.; Jensen, K. J.; Patwardhan, A.; Safavi-Hemami, H.
10.1101/2024.04.29.591104 — pharmacology and toxicology — Posted on 2024-04-30
38 Redox control of the deubiquitinating enzyme Ubp2 regulates translation during stress
Santos, C. M.; Cizubu, B. K.; Okonkwo, D. A.; Chen, C.-Y.; Maske, N.; Snyder, N. A.; Simoes, V.; Washington, E. J.; Silva, G.
10.1101/2024.04.30.591912 — biochemistry — Posted on 2024-04-30
40 Essentiality and dynamic expression of the human tRNA pool during viral infection
Aharon-Hefetz, N.; Schwartz, M.; Dahan, O.; Stern-Ginossar, N.; Pilpel, Y.
10.1101/2024.04.25.591047 — genomics — Posted on 2024-04-30
42 Commonly used organoid culture media prevent ferroptosis
Eaton, J. K.; Chatterji, P.; Sweat, Y. Y.; Victoria, R. A.; Wawer, M. J.; Viswanathan, V. S.
10.1101/2024.04.29.591759 — cancer biology — Posted on 2024-04-30
45 A Low-Cost Microfluidics System for Light Microscopy Experiments
Harrison, L. M.; Brisard, B. M.; Cashwell, K. D.; Mulkey, A. L.; Schmidt, C. A.
10.1101/2024.04.29.591694 — bioengineering — Posted on 2024-04-30
47 Exploring Alu-Driven DNA Transductions in the Primate Genomes
Halabian, R.; Storer, J. M.; Hoyt, S. J.; Hartley, G. A.; Brosius, J.; O'Neill, R. J.; Makalowski, W.
10.1101/2024.04.29.591526 — genetics — Posted on 2024-04-30
48 A claudin5-binding peptide enhances the permeability of the blood-brain-barrier
Berselli, A.; Trevisani, M.; Alberini, G.; Centonze, E.; Vercellino, S.; Cartocci, V.; Millo, E.; Ciubanu, D. Z.; Armirotti, A.; Pisani, F.; Zara, F.; Castagnola, V.; Maragliano, L.; Benfenati, F.
10.1101/2024.04.29.591687 — neuroscience — Posted on 2024-04-30
54 Prediction of anti-freezing proteins from their evolutionary profile
Kumar, N.; Choudhury, S.; Bajiya, N.; Patiyal, S.; Raghava, G. P. S.
10.1101/2024.04.28.591577 — bioinformatics — Posted on 2024-04-30
55 Engineering bacterial protein polymers to support human pluripotent stem cell growth and differentiation in culture.
Creigh, A.; Waller, H.; Lakey, J. H.; Chrzanowska-Lightowlers, Z. M.; Lightowlers, R. N.; Peters, D. T.
10.1101/2024.04.29.591606 — bioengineering — Posted on 2024-04-30
57 Structure of a human monoclonal antibody in complex with Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi
Rudolph, M.; Chen, Y.; Vorauer, C.; Vance, D.; Piazza, C. L.; Willsey, G. G.; McCarthy, K.; Muriuki, B.; Cavacini, L.; Guttman, M.; Mantis, N. J.
10.1101/2024.04.29.591597 — immunology — Posted on 2024-04-30
60 Distinct neural computations scale the violation of expected reward and emotion in social transgressions
Xu, T.; Zhang, L.; Zhou, F.; Fu, K.; Gan, X.; Chen, Z.; Zhang, R.; Lan, C.; Wang, L.; Kendrick, K. K.; Yao, D.; Becker, B.
10.1101/2024.04.29.591585 — neuroscience — Posted on 2024-04-30
62 Sacrificing Adaptability for Functionality: The Ivory Tower of Macular Muller Cells
Zhang, T.; Jin, K.; Zeng, S.; Yang, P.; Zhu, M.; Zhang, J.; Chen, Y.; Lee, S.; Yam, M.; Zeng, Y.; Lu, X.; Loo, L.; Neely, G. G.; Chang, A.; Zhou, F.; Du, J.; Fan, X.; Zhu, L.; Gillies, M.
10.1101/2024.04.28.590478 — neuroscience — Posted on 2024-04-30
64 Modeling mTORopathy-related epilepsy in cultured murine hippocampal neurons using the multi-electrode array
Heuvelmans, A. M.; Proietti Onori, M.; Frega, M.; de Hoogen, J. D.; Nel, E. M.; Elgersma, Y.; van Woerden, G.
10.1101/2024.04.29.591584 — neuroscience — Posted on 2024-04-30
65 Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain.
Pattison, L. A.; Rickman, R. H.; Hilton, H.; Wijesinghe, S. N.; Ladds, G.; Yang, L. V.; Jones, S. W.; Smith, E. S. J.
10.1101/2024.04.29.590277 — neuroscience — Posted on 2024-04-30
67 Megabarcoding reveals a tale of two very different dark taxa along the same elevational gradient
Pei, W.; Feng, V.; Hansen, A. K.; Yan, L.; Srivathsan, A.; Xu, W.; Sun, H.; Yang, J.; Zhang, X.; Yang, N.; Yuan, Q.; Zhang, D.; Meier, R.
10.1101/2024.04.29.591578 — ecology — Posted on 2024-04-30
68 Frequency-dependence in multidimensional diffusion-relaxation correlation MRI of the brain: overfitting or meaningful parameter?
Yon, M.; Narvaez, O.; Martin, J.; Jiang, H.; Bernin, D.; Forssell-Aronsson, E.; Laun, F.; Sierra, A.; Topgaard, D.
10.1101/2024.04.29.591586 — biophysics — Posted on 2024-04-30
70 ESCRT recruitment to damaged lysosomes is dependent on the ATG8 E3-like ligases
Corkery, D. P.; Li, S.; Wijayatunga, D.; Herzog, L. K.; Knyazeva, A.; Wu, Y.
10.1101/2024.04.30.591897 — cell biology — Posted on 2024-04-30
71 Testing models of cell cortex wave generation by Rho GTPases
Chomchai, D. A.; Leda, M.; Golding, A. E.; von Dassow, G.; Bement, W. M.; Goryachev, A. B.
10.1101/2024.04.29.591685 — cell biology — Posted on 2024-04-30
72 RIFINs displayed on malaria-infected erythrocytes bind both KIR2DL1 and KIR2DS1
Sakoguchi, A.; Chamberlain, S. G.; Morch, A. M.; Harrison, T. E.; Dustin, M. L.; Arase, H.; Higgins, M. K.; Iwanaga, S.
10.1101/2024.04.30.591854 — microbiology — Posted on 2024-04-30
75 Manipulating TDP43 Aggregation via RNA G-quadruplexes
Oldani, E. G.; Reynolds Caicedo, K. M.; Spaeth Herda, M. E.; Sachs, A. H.; Chapman, E. G.; Kumar, S.; Linseman, D. A.; Horowitz, S.
10.1101/2024.04.30.591873 — molecular biology — Posted on 2024-04-30
76 Sustained innate interferon is an essential inducer of tertiary lymphoid structures
Calvanese, A. L.; Cecconi, V.; Staehli, S.; Schnepf, D.; Pereira, P.; Gschwend, J.; Heikenwaelder, M.; Schneider, C.; Ludewig, B.; Silina, K.; van den Broek, M.
10.1101/2024.04.30.591846 — immunology — Posted on 2024-04-30
77 High-speed imaging of giant unilamellar vesicle formation in cDICE
Van de Cauter, L.; Jawale, Y. K.; Tam, D.; Baldauf, L.; van Buren, L.; Koenderink, G. H.; Dogterom, M.; Ganzinger, K. A.
10.1101/2023.10.13.562183 — synthetic biology — Posted on 2024-04-30
78 The mechanoreceptor PIEZO1 is a novel oncogene in glioma by promoting astrocyte reactivity
Blanco-Carlon, P.; Navarro-Aguadero, M. A.; Aguilar-Garrido, P.; Otero-Sobrino, A.; Hernandez-Sanchez, M.; Arroyo-Barea, A.; Grana-Castro, O.; Gargini, R.; Garcia-Martin, R. M.; Hernandez-Lain, A.; Perez-Martinez, M.; Gomez-Alonso, J.; Ortega, S.; Martinez-Lopez, J.; Gallardo, M.; Velasco-Estevez, M.
10.1101/2024.04.30.591858 — cancer biology — Posted on 2024-04-30
79 Functional selection in SH3-mediated activation of the PI3 kinase
Aljedani, S. S.; Aldehaiman, A.; Sandholu, A.; Alharb, S.; Mak, V. C. Y.; Wu, H.; Lugari, A.; Jaremko, M.; Morelli, X.; Backer, J.; Ladbury, J. E.; Nowakowski, M.; Cheung, L. W. T.; Arold, S. T.
10.1101/2024.04.30.591319 — biochemistry — Posted on 2024-04-30
82 Glycine max polygalacturonase inhibiting protein 11 (GmPGIP11) functions in the root to suppress Heterodera glycines parasitism
Acharya, S.; Troell, H. A.; Billingsley, R. L.; McKirgan, D. S.; Lawrence, K. S.; Alkharouf, N. W.; Klink, V. P.
10.1101/2024.04.27.591452 — plant biology — Posted on 2024-04-30
83 Genetic characterization of cucumber genetic resources in the NARO Genebank indicates their multiple dispersal trajectories to the East
Shigita, G.; Shimomura, K.; Tran, D. P.; Haque, N. P.; Duong, T. T.; Imoh, O. N.; Monden, Y.; Nishida, H.; Tanaka, K.; Sugiyama, M.; Kawazu, Y.; Tomooka, N.; Kato, K.
10.1101/2024.04.28.591496 — plant biology — Posted on 2024-04-30
89 Inositol pyrophosphate catabolism by three families of phosphatases controls plant growth and development
Laurent, F.; Bartsch, S. M.; Shukla, A.; Rico Resendiz, F. E.; Couto, D.; Fuchs, C.; Nicolet, J.; Loubery, S.; Jessen, H. J.; Fiedler, D.; Hothorn, M.
10.1101/2024.04.30.591831 — plant biology — Posted on 2024-04-30
90 Impact of Species-Specific Plant Growth-Promoting Rhizobacteria (PGPR) on Maize (Zea mays) Phenotypic and Biochemical Diversity
Singh, S.; Roychowdhury, R.; Mukherjee, A.; Kaur, H.; Kaur, R.; Jagota, N.; Sandhu, S.; Kumar, V.; Gupta, M.; Ahn, Y.-H.; Meshram, V.; Sharma, A.
10.1101/2024.04.28.591576 — plant biology — Posted on 2024-04-30
92 The alternative splicing of ZmHsf23 regulates heat stress tolerance in maize
Wang, J.; Song, N.-N.; Qin, Q.-Q.; Su, A.-Q.; Si, W.-N.; Cheng, B.-J.; Jiang, H.-Y.
10.1101/2024.04.28.591503 — plant biology — Posted on 2024-04-30
95 Rules of engagement for condensins and cohesins guide mitotic chromosome formation
Samejima, K.; Gibcus, J. H.; Abraham, S.; Cisneros-Soberanis, F.; Samejima, I.; Beckett, A. J.; Pucekova, N.; Abad, M. A.; Medina-Pritchard, B.; Paulson, J. R.; Xie, L.; Jeyaprakash, A. A.; Prior, I. A.; Mirny, L. A.; Dekker, J.; Goloborodko, A.; Earnshaw, W. C.
10.1101/2024.04.18.590027 — molecular biology — Posted on 2024-04-30
96 Aerobic Adaptation and Metabolic Dynamics of Propionibacterium freudenreichii DSM 20271: Insights from Comparative Transcriptomics and Surfaceome Analysis
Loivamaa, I.; Sillanpää, A.; Deptula, P.; Chamlagain, B.; Edelmann, M.; Auvinen, P.; Nyman, T. A.; Savijoki, K.; Piironen, V.; Varmanen, P.
10.1101/2024.04.30.591863 — microbiology — Posted on 2024-04-30
98 Disorganized Inhibitory Dynamics and Functional Connectivity in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice
Herrlinger, S. A.; Rao, B.; Paredes, M. E. C.; Tuttman, A. L.; Arain, H.; Varol, E.; Gogos, J. A.; Losonczy, A.
10.1101/2024.04.28.591464 — neuroscience — Posted on 2024-04-30
103 FABP4 as a Therapeutic Host Target Controlling SARS-CoV2 Infection
Baazim, H.; Koyuncu, E.; Tuncman, G.; Burak, M. F.; Merkel, L.; Bahour, N.; Karabulut, E. S.; Lee, G. Y.; Hanifehnezhad, A.; Karagoz, Z. F.; Foldes, K.; Engin, I.; Erman, A. G.; Oztop, S.; Filazi, N.; Gul, B.; Ceylan, A.; Cinar, O. O.; Can, F.; Kim, H.; Al-Hakeem, A.; Li, H.; Semerci, F.; Lin, X.; Yilmaz, E.; Ergonul, O.; Ozkul, A.; Hotamisligil, G. S.
10.1101/2024.02.10.579717 — microbiology — Posted on 2024-04-30
105 Evaluation of extraction solvents for untargeted metabolomics to decipher the DOM of Antarctic cryoconite holes
Mundhe, S. D.; Maiti, S.; Sanyal, A.; Kadoo, N. Y.; Dhotre, D.; Barvkar, V. T.; Shaikh, S. A.; Antony, R.; Paul, D.
10.1101/2024.04.29.591772 — microbiology — Posted on 2024-04-30
106 Phenotypic and genomic changes in enteric Klebsiella populations during long-term ICU patient hospitalization: The role of RamR regulation
Langlois, B.; Guerin, F.; Isnard, C.; Gakuba, C.; Du Cheyron, D.; Giard, J.-C.; Brisse, S.; Le Hello, S.; Gravey, F.
10.1101/2024.04.30.591843 — microbiology — Posted on 2024-04-30
107 Reversible host cell surface remodelling limits immune recognition and maximizes transmission of Plasmodium falciparum gametocytes
Ngotho, P.; Dantzler Press, K.; Peedell, M.; Muasya, W.; Omondi, B. R.; Otoboh, S. O.; Seydel, K. B.; Kapulu, M.; Laufer, M.; Taylor, T. E.; Bousema, T.; Marti, M.
10.1101/2024.04.30.591837 — microbiology — Posted on 2024-04-30
108 Viromes of Antarctic fish resembles the diversity found at lower latitudes
Grimwood, R. M.; Waller, S. J.; Wierenga, J. R.; Lim, L.; Dubrulle, J.; Holmes, E. C.; Geoghegan, J. L.
10.1101/2024.04.29.591789 — microbiology — Posted on 2024-04-30
110 P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi
Tal, M. C.; Hansen, P. S.; Ogasawara, H. A.; Feng, Q.; Volk, R. F.; Lee, B.; Casebeer, S. E.; Blacker, G. S.; Shoham, M.; Galloway, S. D.; Sapiro, A. L.; Dulgeroff, L.-B. T.; Raveh, T.; Pothineni, V. R.; Potula, H.-H. S.; Rajadas, J.; Bastounis, E. E.; Chou, S.; Robinson, W. H.; Coburn, J.; Weissman, I. L.; Zaro, B. W.
10.1101/2024.04.29.591704 — immunology — Posted on 2024-04-30
113 Hyaluronidase inhibitor delphinidin inhibits cancer metastasis
Gorbunova, V.; McGuire, J.; Seluanov, A.; Janelsins, M.; Gilmore, N.; Taguchi, T.; Tombline, G.; Paige, V.
10.1101/2024.04.28.591469 — cancer biology — Posted on 2024-04-30
114 Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine
Chatterji, P.; Xing, G.; Furst, L.; Dave, K.; Zhou, Q.; LaBarbera, D. V.; Thamm, D. A.; Eaton, J. K.; Wawer, M. J.; Viswanathan, V. S.
10.1101/2024.04.28.591561 — cancer biology — Posted on 2024-04-30
115 The enzyme glutamate-cysteine ligase (GCL) is a target for ferroptosis induction in cancer
Eaton, J. K.; Chatterji, P.; Furst, L.; Basak, S.; Patel, A. M.; Sweat, Y. Y.; Cai, L. L.; Dave, K.; Victoria, R. A.; Pizzi, E.; Noorbakhsh, J.; Tian, G.; Roth, J. A. S.; Hynes, J.; Xing, G.; Wawer, M. J.; Viswanathan, V. S.
10.1101/2024.04.28.591552 — cancer biology — Posted on 2024-04-30
116 GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche via stromal remodelling
Mulholland, E. J.; Belnoue-Davis, H. L.; Valbuena, G. N.; Gunduz, N.; Ligeza, A.; Biswas, S.; Gil Vasquez, E.; Omwenga, S.; Nasreddin, N.; Hodder, M.; Wang, L. M.; Irshad, S.; Ng, A. S.; Jennings, E. K.; Midwood, K. S.; Dedi, N.; Ridgeway, R.; Phesse, T.; East, J. E.; Tomlinson, I. P. M.; Davies, G. C. G.; Sansom, O. J.; Leedham, S. J.
10.1101/2024.04.28.591245 — cancer biology — Posted on 2024-04-30
117 SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer
Lloyd, E. G.; Jihad, M.; Manansala, J. S.; Li, W.; Cheng, P. S.; Teles, S. P.; Mucciolo, G.; Henriquez, J. A.; Ashworth, S.; Luo, W.; Harish, S.; Johnson, P. M.; Veghini, L.; Zaccaria, M.; Brais, R.; Vallespinos, M.; Corbo, V.; Biffi, G.
10.1101/2024.04.28.591518 — cancer biology — Posted on 2024-04-30
118 Receptor binding and tissue architecture explain the morphogen local-to-global mobility transition
Zhu, S.; Loo, Y. T.; Veerapathiran, S.; Loo, T. Y. J.; Tran, B. N.; Teh, C.; Zhong, J.; Matsudaira, P. T.; Saunders, T. E.; Wohland, T.
10.1101/2024.04.28.591267 — biophysics — Posted on 2024-04-30
120 An Amplification Mechanism for Weak ELF Magnetic Fields Quantum-Bio Effects in Cancer Cells
Zandieh, A.; Shariatpanahi, S. P.; Ravasipour, A.; Azadipour, J.; NezamTaheri, M.; Habibi-Kelishomi, Z.; Ghanizadeh, M.; Same, A.; Majidzadeh, K.; Taheri, A.; Ansari, A. M.; Javidi, M. A.; Pirnia, A.; Goliaei, B.
10.1101/2024.04.28.591462 — biophysics — Posted on 2024-04-30
124 Modelling protein complexes with crosslinking mass spectrometry and deep learning
Stahl, K.; Demann, L.; Bremenkamp, R.; Warneke, R.; Hormes, B.; Stülke, J.; Brock, O.; Rappsilber, J.
10.1101/2023.06.07.544059 — bioinformatics — Posted on 2024-04-30
132 Quantification of tissue creatine content using capillary electrophoresis
Choi, Y. J.; Bautista, A. P.; Terrill, J. R.; Pillow, J. J.; Arthur, P. G.
10.1101/2024.04.09.588648 — biochemistry — Posted on 2024-04-30
133 Plant-animal below-ground interaction modifies plant phenotype and its above-ground interaction: a review and a new case study
Vaca-Benito, C.; Ferron, C.; Velazquez de Castro, A. J.; Munoz-Pajares, A. J.; Abdelaziz, M.; Garcia-Munoz, A.
10.1101/2024.04.29.591669 — ecology — Posted on 2024-04-30
135 Diversity and ecological potentials of viral assemblages from the seamount sediments of the Northwest Pacific Ocean
Chen, Y.; Gao, C.; Liu, Q.; Liang, Y.; Lai, M.; Ge, F.; Yu, H.; Shao, H.; McMinn, A.; Wang, M.
10.1101/2024.04.28.591573 — ecology — Posted on 2024-04-30
136 Post-transcriptional regulatory pre-complex assembly drives timely cell-state transitions during differentiation
Komori, H.; Rastogi, G.; Bugay, J. P.; Luo, H.; Lin, S.; Angers, S.; Smibert, C. A.; Lipshitz, H. D.; Lee, C.-Y.
10.1101/2024.04.29.591706 — developmental biology — Posted on 2024-04-30
137 An inter-organelle contact between endosomal GLP-1R, ER VAP-B, and the mitochondrial AKAP SPHKAP triggers PKA-dependent MIC19 phosphorylation and β-cell mitochondrial remodelling
Austin, G.; ElEid, L.; Oqua, A. I.; Manchanda, Y.; Poliakova, Y.; Bouzakri, K.; Montoya, A.; Withers, D. J.; Jones, B.; Millership, S. J.; Prokopenko, I.; Tomas, A.
10.1101/2024.04.28.591531 — cell biology — Posted on 2024-04-30
138 Functional Localization of the Human Auditory and Visual Thalamus Using a Thalamic Localizer Functional Magnetic Resonance Imaging Task
Williams, J. C.; Tubiolo, P. N.; Zheng, Z. J.; Silver-Frankel, E. B.; Pham, D. T.; Haubold, N. K.; Abeykoon, S. K.; Abi-Dargham, A.; Horga, G.; Van Snellenberg, J. X.
10.1101/2024.04.28.591516 — neuroscience — Posted on 2024-04-30
140 The gut-brain vagal axis scales hippocampal memory processes and plasticity
Onimus, O.; Arrivet, F.; Souza, I. N. d. O.; Bertrand, B.; Castel, J.; Luquet, S.; MOTHET, J.-P.; Heck, N.; Gangarossa, G.
10.1101/2024.04.28.591513 — neuroscience — Posted on 2024-04-30
143 Chromosomal-level genome of fish mint Houttuynia cordata Thunb. (Saururaceae)
Law, S. T. S.; Nong, W.; Tsang, S. S. K.; Lau, D. T. W.; Shaw, P. C.; Hui, J. H. L.
10.1101/2024.04.25.590851 — genomics — Posted on 2024-04-30
148 Tracking exocytic vesicle movements reveals the spatial control of secretion in epithelial cells.
Richens, J. H.; Dmitrieva, M.; Zenner, H. L.; Muschalik, N.; Butler, R.; Glashauser, J.; Camelo, C.; Luschnig, S.; Munro, S.; Rittscher, J.; St Johnston, D.
10.1101/2024.01.25.577201 — cell biology — Posted on 2024-04-30
149 Unifying community-wide whole-brain imaging datasets enables robust automated neuron identification and reveals determinants of neuron positioning in C. elegans
Sprague, D. Y.; Rusch, K.; Dunn, R. L.; Borchardt, J.; Bubnis, G.; Chiu, G.; Wen, C.; Suzuki, R.; Chaudhary, S.; Dichter, B.; Ly, R.; Onami, S.; Lu, H.; Kimura, K.; Yemini, E. I.; Kato, S.
10.1101/2024.04.28.591397 — neuroscience — Posted on 2024-04-30
150 Fungi activate Toll-1 dependent immune evasion to induce cell loss in the host brain
Singh, D. N. D.; Roberts, A. R. E.; Quesada Moraga, E.; Alliband, D.; Ballou, E. R.; Tsai, H.-J.; Hidalgo, A.
10.1101/2024.04.29.591341 — neuroscience — Posted on 2024-04-30
152 CCR7+ Dendritic Cells Define a Type 17 Module in Psoriasis
Sun, Y.; Lou, F.; Cai, X.; Wang, Z.; Yang, X.; Sun, L.; Wu, Z.; Liu, Z.; Shi, Y.; Ginhoux, F.; Wang, H.
10.1101/2024.04.28.591489 — immunology — Posted on 2024-04-30
153 Repix: reliable, reusable, versatile chronic Neuropixels implants using minimal components
Horan, M.; Regester, D.; Mazuski, C.; Jahans-Price, T.; Bailey, S.; Thompson, E. J.; Slonina, Z.; Plattner, V.; Menichini, E.; Toksoz, I.; Pinto, S. R.; Burrell, M.; Varsavsky, I.; Dalgleish, H. W. P.; Bimbard, C.; Lebedeva, A.; Bauza, M.; Cacucci, F.; Wills, T.; Akrami, A.; Krupic, J.; Stephenson-Jones, M.; Barry, C.; Burgess, N.; O'Keefe, J.; Isogai, Y.
10.1101/2024.04.25.591118 — neuroscience — Posted on 2024-04-30
155 A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome
Ahuja, K.; Vandenabeele, M.; Nami, F.; Lefevere, E.; Van hoecke, J.; Bergmans, S.; Claes, M.; Vervliet, T.; Neyrinck, K.; Burg, T.; De Herdt, D.; Bhaskar, P.; Zhu, Y. L.; Looser, Z.; Loncke, J.; Gsell, W.; Plaas, M.; Agostinis, P.; Swinnen, J. V.; Van Den Bosch, L.; Bultynck, G.; Saab, A. A.; Wolfs, E.; Chai, Y. C.; Himmelreich, U.; Verfaillie, C.; Moons, L.; De Groef, L.
10.1101/2024.04.28.591501 — neuroscience — Posted on 2024-04-30
158 Defense-related callose synthase PMR4 promotes root hair callose deposition and adaptation to phosphate deficiency in Arabidopsis thaliana
Okada, K.; Yachi, K.; Nguyen, T. A. N.; Kanno, S.; Yasuda, S.; Tadai, H.; Tateda, C.; Lee, T.-H.; Nguyen, U.; Inoue, K.; Miyashima, S.; Hiruma, K.; Miwa, K.; Maekawa, T.; Notaguchi, M.; Saijo, Y.
10.1101/2023.07.05.547890 — plant biology — Posted on 2024-04-30
160 Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target
Lynch, K. R.; Kharel, Y.; Huang, T.; Dunnavant, K.; Foster, D.; Santos, W.; Xu, W.; Gaultier, A.; Merchak, A.; Leitinger, N.; Pavelec, C.; Abbott, S. B.; Souza, G. M.; Nimchuk, K. T.; Shin, J.-B.; Isakson, B. E.; Juskiewicz, Z. J.
10.1101/2024.03.26.586765 — pharmacology and toxicology — Posted on 2024-04-30
164 Characterization of the mesendoderm progenitors in the gastrulating mouse embryo
Masamsetti, V. P.; Salehin, N.; Kim, H. J.; Santucci, N.; Weatherstone, M.; Knowles, H.; Sun, J.; McMahon, R.; Studdert, J. B.; Aryamanesh, N.; Wang, R.; Jing, N.; Yang, P.; Osteil, P.; Tam, P. P. L.
10.1101/2024.04.28.591221 — developmental biology — Posted on 2024-04-30
165 DBT is a metabolic switch for maintenance of proteostasis under proteasomal impairment
Hwang, R.-D.; Lu, Y.; Tang, Q.; Periz, G.; Park, G.; Li, X.; Xiang, Q.; Liu, Y.; Zhang, T.; Wang, J.
10.1101/2023.09.12.556394 — neuroscience — Posted on 2024-04-30
167 Loss of spontaneous vasomotion precedes impaired cerebrovascular reactivity and microbleeds in a mouse model of cerebral amyloid angiopathy
Kozberg, M. G.; Munting, L. P.; Maresco, L. H.; Auger, C. A.; van den Berg, M. L.; Denis de Senneville, B.; Hirschler, L.; Warnking, J. M.; Barbier, E. L.; Farrar, C. T.; Greenberg, S. M.; Bacskai, B.; van Veluw, S. J.
10.1101/2024.04.26.591414 — neuroscience — Posted on 2024-04-30
172 Foot orientation and trajectory variability in locomotion: effects of real-world terrain
Gibson, E.; Douglas, G.; Jeffries, K.; Delaurier, J.; Chestnut, T.; Charlton, J. M.
10.1101/2023.10.18.562999 — bioengineering — Posted on 2024-04-30
173 An AI-designed adenine base editor
Yuan, Y.; Chen, Y.; Liu, R.; Que, G.; Yuan, Y.; Li, G.
10.1101/2024.04.28.591233 — bioengineering — Posted on 2024-04-30
174 A Haplotype-resolved, Chromosome-scale Genome for Malus domestica 'WA 38'
Zhang, H.; Eaker, A.; Ko, I.; Haney, S.; Khuu, N.; Ryan, K.; Appleby, A.; Hoffmann, B.; Landis, H.; Pierro, K.; Willsea, N.; Hargarten, H.; Yocca, A.; Harkess, A.; Honaas, L.; Ficklin, S.
10.1101/2024.01.10.574953 — genomics — Posted on 2024-04-30
175 Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements
Chardon, F. M.; McDiarmid, T. A.; Page, N. F.; Daza, R.; Martin, B. K.; Domcke, S.; Regalado, S. G.; Lalanne, J.-B.; Calderon, D.; Li, X.; Starita, L. M.; Sanders, S. J.; Ahituv, N.; Shendure, J.
10.1101/2023.03.28.534017 — genomics — Posted on 2024-04-30
178 Activity-dependent COX-2 proteolysis generates a catalytically inactive fragment that affects aerobic respiration and proliferation
Hartal-Benishay, L. H.; Tal, S.; Abd Elkader, A.; Ehsainieh, O.; Sroji-Eid, R.; Mikl, M.; Barki-Harrington, L.
10.1101/2024.04.08.588559 — cell biology — Posted on 2024-04-30
179 Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell of Streptococcus pneumoniae
Perez, A. J.; Lamanna, M. M.; Bruce, K. E.; Touraev, M. A.; Page, J. E.; Shaw, S. L.; Tsui, H.-C. T.; Winkler, M. E.
10.1101/2024.01.10.575112 — microbiology — Posted on 2024-04-30
181 Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands
Wang, L.; Maharjan, C.; Borcherding, N.; Master, R. P.; Mo, j.; Tithi, T. I.; Carelock, M.; Master, A.; Gibson-Corley, K.; Kolb, R. H.; Smith, K. A.; Zhang, W.
10.1101/2024.04.25.591178 — immunology — Posted on 2024-04-30
183 Cholinergic mu-opioid receptor deletion alters reward preference and aversion-resistance
Beane, C. R.; Lewis, D. G.; Bruns, N. K.; Pikus, K. L.; Durfee, M. H.; Zegarelli, R. A.; Perry, T. W.; Sandoval, O.; Radke, A. K.
10.1101/2023.11.13.566881 — neuroscience — Posted on 2024-04-30
184 Sex Differences in the Brain's White Matter Microstructure during Development assessed using Advanced Diffusion MRI Models
Benavidez, S. M.; Abaryan, Z.; Kim, G. S.; Laltoo, E.; McCracken, J. T.; Thompson, P. M.; Lawrence, K. E.
10.1101/2024.02.02.578712 — neuroscience — Posted on 2024-04-30
185 DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response
Yulyaningsih, E.; Suh, J. H.; Fanok, M. H.; Chau, R.; Solanoy, H.; Takahashi, R.; Bakardjiev, A. I.; Becerra, I.; Benitez, N. B.; Chiu, C.-L.; Davis, S. S.; Dowdle, W. E.; Earr, T.; Estrada, A. E.; Gill, A.; Ha, C.; Haddick, P. C. G.; Henne, K. R.; Larhammar, M.; Leung, A. W.; Maciuca, R.; Memarzadeh, B.; Nguyen, H. N.; Nugent, A.; Osipov, M.; Ran, Y.; Rebadulla, K.; Roche, E.; Sandmann, T.; Wang, J.; Lewcock, J. W.; Scearce-Levie, K.; Kane, L. A.; Sanchez, P. E.
10.1101/2023.08.21.554203 — neuroscience — Posted on 2024-04-30
186 Single-Domain Antibody-Based Protein Degrader for Synucleinopathies
Jiang, Y.; Lin, Y.; Tetlow, A. M.; Pan, R.; Ji, C.; Kong, X.-P.; Congdon, E. E.; Sigurdsson, E. M.
10.1101/2024.03.11.584473 — neuroscience — Posted on 2024-04-30
187 Neural populations in the language network differ in the size of their temporal receptive windows
Regev, T. I.; Casto, C.; Hosseini, E. A.; Adamek, M.; Ritaccio, A. L.; Willie, J. T.; Brunner, P.; Fedorenko, E.
10.1101/2022.12.30.522216 — neuroscience — Posted on 2024-04-30
189 Deciphering compromised speech-in-noise intelligibility in older listeners: the influence of cochlear synaptopathy
Garrett, M.; Vasilkov, V.; Mauermann, M.; Wilson, J. L.; Gonzalez, L.; Henry, K. S.; Verhulst, S.
10.1101/2020.06.09.142950 — neuroscience — Posted on 2024-04-30
194 Etrinabdione (VCE-004.8), a B55a activator, promotes angiogenesis and arteriogenesis in critical limb ischemia.
Garcia-Martin, A.; Prados, M. E.; Lastres-Cubillo, I.; Ponce-Diaz, F. J.; Cerero, L.; Garrido-Rodriguez, M.; Navarrete, C.; Pineda, R.; Rodriguez, A. B.; Munoz, I.; Moya, J.; Medeot, A.; Moreno, J. A.; Chacon, A.; Garcia-Revillo, J.; Munoz, E.
10.1101/2024.04.26.591240 — pharmacology and toxicology — Posted on 2024-04-30
195 An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma
Fraire, C. R.; Desai, K.; Obalapuram, U. A.; Mendyka, L. K.; Rajaram, V.; Sebastian, T.; Wang, Y.; Onel, K.; Lee, J.; Chen, K. S.
10.1101/2024.04.23.590638 — cancer biology — Posted on 2024-04-30
196 Uncovering Protein Ensembles: Automated Multiconformer Model Building for X-ray Crystallography and Cryo-EM
Wankowicz, S. A.; Ravikumar, A.; Sharma, S.; Riley, B.; Raju, A.; Hogan, D. W.; Flowers, J.; van den Bedem, H.; Keedy, D. A.; Fraser, J. S.
10.1101/2023.06.28.546963 — biophysics — Posted on 2024-04-30
199 GFPrint™: A MACHINE LEARNING TOOL FOR TRANSFORMING GENETIC DATA INTO CLINICAL INSIGHTS
Sanz-Martin, G.; Migliore, D. P.; Gomez del Campo, P.; del Castillo-Izquierdo, J.; Dominguez, J. M.
10.1101/2024.03.08.584090 — bioinformatics — Posted on 2024-04-30
200 A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system
Aleman, J.; K, R.; Wiegand, C.; Schurdak, M. E.; Vernetti, L.; Gavlock, D.; Reese, C.; DeBiasio, R.; LaRocca, G.; Angarita, Y. D.; Gough, A.; Soto-Gutierrez, A.; Behari, J.; Yechoor, V.; Miedel, M. T.; Stern, A. M.; Banerjee, I.; Taylor, D. L.
10.1101/2024.04.22.590598 — bioengineering — Posted on 2024-04-30
201 Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells
Ma, L.; Ramasubramanian, R.; Mehta, N.; Cossette, B.; Morgan, D.; Sukaj, I.; Bergaggio, E.; Kadauke, S.; Myers, R.; Paruzzo, L.; Ghilardi, G.; Grzywa, T.; Cozzone, A.; Schuster, S.; Frey, N.; Zhang, L.; Yousefpour, P.; Abraham, W.; Suh, H.; Ruella, M.; Grupp, S.; Chiarle, R.; Wittrup, K. D.; Irvine, D. J.
10.1101/2024.04.16.589780 — bioengineering — Posted on 2024-04-30
206 Long-term citizen science data reveals environmental controls on tropical tree flowering at the regional scale
Anujan, K.; Mardian, J.; Luo, C.; Rajkumar, R.; SeasonWatch Citizen Scientist Network, ; Tasic, H.; Akseer, N.; Ramaswami, G.
10.1101/2023.03.24.533907 — ecology — Posted on 2024-04-30
207 Tmc7 deficiency causes acrosome biogenesis defects and male infertility in mice
Wang, J.; Yin, Y.; Yang, L.; Qin, J.; Wang, Z.; Qiu, C.; Gao, Y.; Lu, G.; Gao, F.; Chen, Z.-J.; Zhang, X.; Liu, H.; Liu, Z.
10.1101/2024.01.18.576276 — developmental biology — Posted on 2024-04-30
208 Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy
Xia, M.; Varmazyad, M.; Palacin, I. P.; Gavlock, D. C.; Debiasio, R.; LaRocca, G.; Reese, C.; Florentino, R.; Faccioli, L. A. P.; Brown, J. A.; Vernetti, L. A.; Schurdak, M. E.; Stern, A. M.; Gough, A.; Behari, J.; Soto-Gutierrez, A.; Taylor, D. L.; Miedel, M.
10.1101/2024.04.22.590608 — cell biology — Posted on 2024-04-30
209 Gαi2 Interaction with EB1 Controls Microtubule Dynamics and Rac1 Activity in Xenopus Neural Crest Cell Migration
Villaseca, S.; Leal, J. I.; Tovar, L. M.; Ruiz, M. J.; Guajardo, J.; Morales-Navarrete, H.; Mayor, R.; Torrejon, M.
10.1101/2023.09.07.556733 — cell biology — Posted on 2024-04-30
210 Deciphering the phospho-signature induced by hepatitis B virus in primary human hepatocytes
Pastor, F.; Charles, E.; Belmudes, L.; Chabrolles, H.; Cescato, M.; Rivoire, M.; Burger, T.; Passot, G.; Durantel, D.; Lucifora, J.; Coute, Y.; SALVETTI, A.
10.1101/2024.04.10.588822 — microbiology — Posted on 2024-04-30
214 Sex-specific resilience of neocortex to food restriction
Padamsey, Z.; Katsanevaki, D.; Maeso, P.; Rizzi, M.; Osterweil, E. E.; Rochefort, N. L.
10.1101/2023.10.06.561185 — neuroscience — Posted on 2024-04-30
218 Molecular and neural mechanisms of behavioural integration in the extended-amygdala
Chang, S.; Fermani, F.; Huang, L.; Schneider, S.; Mathis, M. W.; Deussing, J. M.; Cai, N.
10.1101/2024.04.29.591588 — neuroscience — Posted on 2024-04-29
221 The chromatin remodeler CHD3 is highly expressed in mature neurons and regulates genes involved in synaptic development and function
den Hoed, J.; Wong, M. M. K.; Claassen, W. J. J.; de Hoyos, L.; Lütje, L.; Heide, M.; Huttner, W. B.; Fisher, S. E.
10.1101/2024.04.29.591720 — neuroscience — Posted on 2024-04-29
223 Comparative genomics of the extremophile Cryomyces antarcticus and other psychrophilic Dothideomycetes
Gomez-Gutierrez, S. V.; Sic Hernandez, W. R.; Haridas, S.; LaButti, K.; Eichenberger, J.; Kaur, N.; Lipzen, A.; Barry, K. W.; Goodwin, S. B.; Gribskov, M. V.; Grigoriev, I. V.
10.1101/2024.04.29.590463 — genomics — Posted on 2024-04-29
224 Polyadenylated RNA sequencing analysis helps establish a reliable catalog of circular RNAs - a bovine example.
Robic, A.; Hadlich, H.; Costa Monteiro Moreira, G.; Clark, E. L.; Plastow, G.; Charlier, C.; Kuehn, C.
10.1101/2024.04.29.591253 — genomics — Posted on 2024-04-29
225 Non-additive dosage-dependent effects of TaGS3 gene editing on grain size and weight in wheat
Wang, W.; Pan, Q.; Tian, B.; Davidson, D.; Bai, G.; Akhunova, A.; Trick, H. N.; Akhunov, E.
10.1101/2024.04.28.591550 — genetics — Posted on 2024-04-29
226 Proposed network of Marine Protected Areas supports larval dispersal and connectivity in the Eastern Mediterranean
Berenshtein, I.; Stern, N.; Tagar, A.; Morov, A.; Paris, C. B.; Lapidot, O.; Fredj, E.; Zaken, J.; Biton, E.
10.1101/2024.04.28.591505 — ecology — Posted on 2024-04-29
227 Multiomic analysis reveals developmental dynamics of the human heart in health and disease
Cranley, J.; Kanemaru, K.; Bayraktar, S.; Knight-Schrijver, V.; Pett, J. P.; Polanski, K.; Dabrowska, M.; Mulas, I.; Richardson, L.; Semprich, C.; Kapuge, R.; Perera, S.; He, X.; Ho, S. Y.; Yayon, N.; Tuck, L.; Roberts, K.; Palmer, J.; Davaapil, H.; Gambardella, L.; Patel, M.; Tyser, R.; Sinha, S.; Teichmann, S.
10.1101/2024.04.29.591736 — developmental biology — Posted on 2024-04-29
231 Functional Biosynthetic Stereodivergence in a Gene Cluster via a Dihydrosydnone N-oxide
Ren, J.; Mathew, A.; Rodriguez Garcia, M.; Kohler, T.; Blacque, O.; Linden, A.; Eberl, L.; Sieber, S.; Gademann, K.
10.1101/2024.04.29.591611 — biochemistry — Posted on 2024-04-29
232 Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals
Lithgo, R. M.; Tomlinson, C. W. E.; Fairhead, M.; Winokan, M.; Thompson, W.; Wild, C.; Aschenbrenner, J.; Balcomb, B.; Marples, P. G.; Chandran, A. V.; Golding, M. N.; Koekemoer, L.; Williams, E. P.; Wang, S.; Ni, X.; MacLean, E. M.; Giroud, C.; Zarganes-Tzitzikas, T.; Schutzer de Godoy, A.; Xavier, M.-A.; Walsh, M.; Fearon, D.; von Delft, F.
10.1101/2024.04.29.591684 — biochemistry — Posted on 2024-04-29
233 Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1
Doppler, D.; Grieco, A.; Koh, D.; Manna, A.; Ansari, A.; Alvarez, R.; Karpos, K.; Le, H.; Sonker, M.; Ketawala, G.; Mahmud, S.; Quereda Moraleda, I.; Pey, A. L.; Letrun, R.; Doerner, K.; Koliyadu, J. C. P.; de Wijn, R.; Bielecki, J.; Han, H.; Kim, C.; Koua, F.; Round, A.; Sarma, A.; Sato, T.; Schmidt, C.; Vakili, M.; Zabelskii, D.; Bean, R.; Mancuso, A. P.; Schulz, J.; Fromme, R.; Medina, M.; Grant, T. D.; Fromme, P.; Kirian, R. A.; Botha, S.; Martin Garcia, J. M.; Ros, A.
10.1101/2024.04.29.591466 — biochemistry — Posted on 2024-04-29
234 Dynamical Responses Predict a Distal Site that Modulates Activity in an Antibiotic Resistance Enzyme
Beer, M.; Oliveira, A. S. F.; Tooke, C. L.; Hinchliffe, P.; Li, A. T. Y.; Balega, B.; Spencer, J.; Mulholland, A. J.
10.1101/2024.04.29.591639 — biochemistry — Posted on 2024-04-29
235 Uncovering the molecular interactions underlying MBD2 and MBD3 phase separation
Nicole, M.; Phan, T.; Henty-Ridilla, J. L.; Kim, Y. C.; Mittal, J.; Bah, A.
10.1101/2024.04.29.591564 — biochemistry — Posted on 2024-04-29
236 Crystallographic fragment screening delivers diverse chemical scaffolds for Zika virus NS2B-NS3 protease inhibitor development
Ni, X.; de Godoy, A. S.; Marples, P. G.; Fairhead, M.; Balcomb, B. H.; Ferla, M. P.; Tomlinson, C. W. E.; Wang, S.; Girould, C.; Aschenbrenner, J. C.; Lithgo, R.; Winokan, M.; Chandran, A. V.; Thompson, W.; Xavier, M.-A. E.; Williams, E.; Walsh, M. A.; Fearon, D.; Koekemoer, L.; von Delft, F.
10.1101/2024.04.29.591502 — biochemistry — Posted on 2024-04-29
238 IPMK regulates HDAC3 activity and histone H4 acetylation in human cells.
Sowd, G. A.; Stivision, E. A.; Chapagain, P.; Hale, A. T.; Poland, J. C.; Rameh, L. E.; Blind, R. D.
10.1101/2024.04.29.591660 — biochemistry — Posted on 2024-04-29
239 Stem cell models of TAFAZZIN deficiency reveal novel tissue-specific pathologies in Barth Syndrome
Carney, O. S.; Harris, K. W.; Wohlfarter, Y.; Lee, K.; Butschek, G.; Anzmann, A.; Claypool, S. M.; Hamacher-Brady, A.; Keller, M. A.; Vernon, H. J.
10.1101/2024.04.28.591534 — cell biology — Posted on 2024-04-29
240 NAC-mediated ribosome localization regulates cell fate and metabolism in intestinal stem cells
Ramalho, S.; Alkan, F.; Prekovic, S.; Jastrzebski, K.; Pinto Barbera, E.; Hoekman, L.; Altelaar, M.; van der Kammen, R.; Fedry, J.; de Gooijer, M. C.; Faller, W. J.; Silva, J.
10.1101/2024.04.29.591601 — molecular biology — Posted on 2024-04-29
241 Communication between DNA polymerases and Replication Protein A within the archaeal replisome
Martinez-Carranza, M.; Vialle, L.; Madru, C.; Cordier, F.; Dizkirici Tekpinar, A.; Haouz, A.; Legrand, P.; Le Meur, R. A.; England, P.; Dulermo, R.; Guijarro, I. J.; Henneke, G.; Sauguet, L.
10.1101/2024.04.29.591592 — molecular biology — Posted on 2024-04-29
244 Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states
Okada, J.; Landgraf, A.; Xiaoli, A. M.; Liu, L.; Horton, M.; Schuster, V. L.; Yang, F.; Sidoli, S.; Qiu, Y.; Kurland, I. J.; Eliscovich, C.; Shinoda, K.; Pessin, J. E.
10.1101/2024.04.29.591168 — molecular biology — Posted on 2024-04-29
247 A global atlas of subsurface microbiomes reveals phylogenetic novelty, large scale biodiversity gradients, and a marine-terrestrial divide
Ruff, S. E.; Hrabe de Angelis, I. C.; Mullis, M.; Payet, J. P.; Magnabosco, C.; Lloyd, K. G.; Sheik, C.; Steen, A. D.; Shipunova, A.; Morozov, A.; Kiel Reese, B.; Bradley, J. A.; Lemonnier, C.; Schrenk, M. O.; Joye, S. B.; Huber, J. A.; Probst, A. J.; Morrison, H. G.; Sogin, M. L.; Ladau, J.; Colwell, F.
10.1101/2024.04.29.591682 — microbiology — Posted on 2024-04-29
248 Investigating Novel Streptomyces Bacteriophage Endolysins as Potential Antimicrobial Agents
Maneekul, J.; Chiaha, A.; Hughes, R.; Labry, F.; Saito, J.; Almendares, M.; Banda, B. N.; Lopez, L.; McGaskey, N.; Miranda, M.; Rana, J.; Zadeh, B. R.; Hughes, L. E.
10.1101/2024.04.29.591658 — microbiology — Posted on 2024-04-29
249 A pervasive large conjugative plasmid mediates multispecies biofilm formation in the intestinal microbiota increasing resilience to perturbations
Garcia-Bayona, L.; Said, N.; Coyne, M. J.; Flores, K.; Elmekki, N. M.; Sheahan, M.; Camacho, A. G.; Hutt, K.; Yildiz, F. H.; Kovacs, A. T.; Waldor, M. K.; Comstock, L. E.
10.1101/2024.04.29.590671 — microbiology — Posted on 2024-04-29
250 Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity
Boudrioua, A.; Joiner, J. D.; Grin, I.; Kronenberger, T.; Korotkov, V. S.; Steinchen, W.; Kohler, A.; Schminke, S.; Schulte, J.-C.; Pietsch, M.; Naini, A.; Kalverkamp, S.; Hotop, S.-K.; Coyle, T.; Piselli, C.; Coles, M.; Rox, K.; Marschal, M.; Bange, G.; Flieger, A.; Poso, A.; Bronstrup, M.; Hartmann, M. D.; Wagner, S.
10.1101/2024.04.29.591313 — microbiology — Posted on 2024-04-29
251 Emergent survival and extinction of species within gut bacterial communities
van den Berg, N. I.; Tramontano, M.; Guan, R.; Andrejev, S.; Blasche, S.; Kim, Y.; Klunemann, M.; Gontao Brochado, A. R.; Kalmar, L.; Telzerow, A.; Bork, P.; Sevin, D.; Typas, A.; Patil, K. R.
10.1101/2024.04.29.591619 — microbiology — Posted on 2024-04-29
252 Investigating the translational value of Periprosthetic Joint Infection (PJI) models to determine the risk and severity of Staphylococcal biofilms.
Sekar, A.; Fan, Y.; Tierney, P.; McCanne, M.; Jones, P.; Malick, F.; Kannambadi, D.; Wannomae, K. K.; Inverardi, N.; Yuh, J.; Lekkala, S.; Muratoglu, O. K.; Oral, E.
10.1101/2024.04.29.591689 — microbiology — Posted on 2024-04-29
253 Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN.1 and other variants
Piepenbrink, M. S.; Khalil, A. M.; Chang, A.; Mostafa, A.; Basu, M.; Sarkar, S.; Panjwani, S.; Ha, Y. H.; Ma, Y.; Ye, C.; Wang, Q.; Green, T. J.; Kizziah, J. L.; Erdmann, N. B.; Goepfert, P. A.; Lihong, L.; Ho, D. D.; Martinez-Sobrido, L.; Walter, M. R.; Kobie, J. J.
10.1101/2024.04.27.591446 — immunology — Posted on 2024-04-29
254 Characterization of Collaborative Cross mouse founder strain CAST/EiJ as a novel model for lethal COVID-19
Baker, C.; Duso, D.; Kothapalli, N.; Hart, T.; Casey, S.; Kummer, L.; Cookenham, T.; Hvizdos, J.; Lanzer, K.; Vats, P.; Shanbhag, P.; Bell, I.; Tighe, M.; Travis, K.; Szaba, F.; Bedard, O.; Oberding, N.; Ward, J. M.; Adams, M.; Lutz, C. M.; Bradrick, S. S.; Reiley, W. W.; Rosenthal, N.
10.1101/2024.04.26.591329 — immunology — Posted on 2024-04-29
255 Curved light sheet microscopy for centimeter-scale cleared tissues imaging
Tang, L.; Wang, J.; Ding, J.; Sun, J.; Chen, X.-j.; Shen, Q.; Song, R.; Cao, P.; Gong, R.; Xu, F.; Ge, W.-p.; Sun, W.; Zhao, H.; Wu, J.
10.1101/2024.04.28.591483 — bioengineering — Posted on 2024-04-29
257 A high-throughput screening platform for discovering bacterial species and small molecules that modify animal physiology
Nauta, K. M.; Gates, D. R.; Llontop, M. E. M.; Wang, X.; Nguyen, K. P.; Isaguirre, C. N.; Genjdar, M.; Sheldon, R.; Burton, N. O.
10.1101/2024.04.29.591726 — genetics — Posted on 2024-04-29
260 Enhancement of spatial learning by 40 Hz visual stimulation requires parvalbumin interneuron-dependent hippocampal neurogenesis
Yan, H.; Deng, X.; Wang, Y.; Wu, S.; Jun, D.; Yu, M.; Liu, B.; Wang, H.; Pan, Y.; Zhang, Z.; Chen, J.; Wang, Y.; Walker, T.; Bartlett, P.; Ju, J.; Hou, S.-T.
10.1101/2024.04.28.591481 — neuroscience — Posted on 2024-04-29
262 Autophagy is suppressed in peripheral blood mononuclear cells during chronic obstructive pulmonary disease.
Cooper, J.; Chen, S.; Lester, S. E.; Kim, J.; Gummow, J. A.; Crowhurst, T.; Lawton, E.; Badiei, A.; Nguyen, P. T.; Roscioli, E.
10.1101/2024.04.27.591479 — molecular biology — Posted on 2024-04-29
263 An AI-designed adenine base editor
Yuan, Y.; Chen, Y.; Liu, R.; Que, G.; Yuan, Y.; Li, G.
10.1101/2024.04.28.591233 — bioengineering — Posted on 2024-04-29
264 NADPH composite index analysis quantifies the relationship between compartmentalized NADPH dynamics and growth rates in cancer cells
Moon, S. J.; Chiappino-Pepe, A.; Dong, W.; Kelleher, J. K.; Vander Heiden, M.; Stephanopoulos, G.; Sikes, H. D.
10.1101/2024.04.27.591477 — systems biology — Posted on 2024-04-29
265 Oral bioavailability of a noncoding RNA drug, TY1, that acts on macrophages
Yamaguchi, S.; Yamamoto, K.; Jones, X.; Ciullo, A.; Morris, A.; Tsi, K.; Marban, E.; Ibrahim, A. G.-E.
10.1101/2024.04.27.591474 — synthetic biology — Posted on 2024-04-29
268 Identification and characterization of alamandine-(1-5), a new component of the Renin-Angiotensin System with unique properties
Dias, M. T. S.; Goncalves, S. C. d. A.; da Silva, F. A.; Rodrigues-Ribeiro, L.; Ferraz, K. S.; Scalzo, S.; F Itaborahy, M.; Soares, N. P.; Alves Pereira, D. A.; Vaz de Castro, P. A. S.; Dutra, J. B. R.; Barros, C. F.; Vieira-Machado, U. F.; Feng, I.; Ventris-Godoy, A. C.; Monteiro, A. H. A.; Eliezeck, M.; Sanches, B.; Monteiro, A. L. L.; Bessa, A. d. S. M.; Davel, A. P.; Nobrega, N.; Rezende-Ribeiro, J.; Dias-Pinto, M. L.; Silva, B. D. d.; Souza, L. E. d.; Silva, A. d. A.; Bader, M.; Alenina, N.; Capettini, L.; Campagnole-Santos, M. J.; Verano-Braga, T.; Fontes, M. A. P.; Haibara, A. S.; Ville
10.1101/2024.04.27.591083 — physiology — Posted on 2024-04-29
269 IL-12/IL23 blockade reveals patterns of asynchronous inflammation in pyoderma gangrenosum
Yadav, R.; Vague, M.; Rettig, M.; Loo, C. P.; Brown, K.; Samiea, A.; Moreau, J. M.; Ortega-Loayza, A. G.
10.1101/2024.04.26.591387 — immunology — Posted on 2024-04-29
271 Lesions that Cause Psychosis Map to a Common Brain Circuit in the Hippocampus
Pines, A. R.; Frandsen, S. B.; Drew, W.; Meyer, G. M.; Howard, C.; Palm, S. T.; Schaper, F. L. W. V. J.; Lin, C.; Butenko, K.; Ferguson, M. A.; Friedrich, M. U.; Grafman, J. H.; Kappel, A. D.; Neudorfer, C.; Rost, N. S.; Sanderson, L. L.; Wu, O.; Kletenik, I.; Vogel, J. W.; Cohen, A. L.; Horn, A.; Fox, M. D.; Silbersweig, D.; Siddiqi, S. H.
10.1101/2024.04.28.591471 — neuroscience — Posted on 2024-04-29
272 High-throughput crystallographic fragment screening of Zika virus NS3 Helicase
Godoy, A. S.; Mesquita, N. C. M. R.; Noske, G. D.; Gawriljuk, V. O.; Lithgo, R. M.; Balcomb, B. H.; Aschenbrenner, J. C.; Tomlinson, C. W. E.; Winokan, M.; Scheen, J.; Marples, P. G.; Chandran, A. V.; Ni, X.; Thompson, W.; Fairhead, M.; Fearon, D.; Koekemoer, L.; Xavier, M.-A. E.; Walsh, M.; Oliva, G.; von Delft, F.
10.1101/2024.04.27.591279 — biophysics — Posted on 2024-04-29
273 Rare germline structural variants increase risk for pediatric solid tumors
Gillani, R.; Collins, R. L.; Crowdis, J.; Garza, A.; Jones, J. K.; Walker, M.; Sanchis-Juan, A.; Whelan, C. W.; Pierce-Hoffman, E.; Talkowski, M. E.; Brand, H.; Haigis, K. M.; LoPiccolo, J.; AlDubayan, S. H.; Gusev, A. H.; Crompton, B. D.; Janeway, K.; Van Allen, E.
10.1101/2024.04.27.591484 — genomics — Posted on 2024-04-29
274 Immune-profiling of T helper 1 (Th1), Th2 and Th17 signatures in murine splenocytes by targeting intracellular cytokines
Barman, S.; Kelly, A.; Dong, D.; Patel, A.; Buonopane, M. J.; Gonzales, J.; Janoschek, B.; Draghi, A.; Dowling, D. J.
10.1101/2024.04.27.591473 — immunology — Posted on 2024-04-29
276 Latent cytomegalovirus is associated with reduced functional antibody induction following Plasmodium falciparum infection
Mukhiya, R.; Loughland, J. R.; Chan, J.-A.; de Labastida Rivera, F.; Andrew, D.; Beeson, J. G.; McCarthy, J. S.; Barber, B.; Lopez, J. A.; Engwerda, C.; Boyle, M. J.
10.1101/2024.04.28.591548 — immunology — Posted on 2024-04-29
277 Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy
Unda, S. R.; Pomeranz, L. E.; Marongiu, R.; Yu, X.; Kelly, L.; Hassanzadeh, G.; Molina, H.; Vaisey, G.; Wang, P.; Dyke, J. P.; Fung, E. K.; Grosenick, L.; Zirkel, R.; Antoniazzi, A. M.; Norman, S.; Liston, C. M.; Schaffer, C. B.; Nishimura, N.; Stanley, S. A.; Friedman, J. M.; Kaplitt, M. G.
10.1101/2023.07.13.548699 — neuroscience — Posted on 2024-04-29
280 Investigating the Triple Code Model in Numerical Cognition Using Stereotactic Electroencephalography
Tan, H.; Rockhill, A. P.; Lopez Ramos, C. G.; Nerison, C.; Shafie, B.; Shahin, M. N.; Fecker, A. L.; Ismail, M.; Cleary, D. R.; Collins, K. L.; Raslan, A. M.
10.1101/2024.04.27.591485 — neuroscience — Posted on 2024-04-29
282 In-situ serial crystallography facilitates 96-well plate structuralanalysis at low symmetry
Foos, N.; Florial, J.-B.; Eymery, M. C.; Sinoir, J.; Felisaz, F.; Oscarsson, M.; Beteva, A.; Bowler, M. W.; Nurizzo, D.; Papp, G.; Soler Lopez, M.; Nanao, M.; Basu, S.; McCarthy, A. A.
10.1101/2024.04.28.591338 — biophysics — Posted on 2024-04-29
284 Bacterial stress granule protects mRNA through ribonucleases exclusion
Pei, L.; Xian, Y.; Yan, X.; Schaefer, C.; Syeda, A. H.; Howard, J.; Liao, H.; Bai, F.; Leake, M. C.; Pu, Y.
10.1101/2024.04.27.591437 — biophysics — Posted on 2024-04-29
286 Experimental evolution of S. cerevisiae for caffeine tolerance alters multidrug resistance and TOR signaling pathways
Geck, R. C.; Moresi, N. G.; Anderson, L. M.; yEvo Students, ; Brewer, R.; Renz, T. R.; Taylor, M. B.; Dunham, M. J.
10.1101/2024.04.28.591555 — genetics — Posted on 2024-04-29
287 Damaging mutations in LXRα uncouple lipogenesis from hepatotoxicity and implicate hepatic cholesterol sensing in human liver health
Lockhart, S. M.; Muso, M.; Zvetkova, I.; Lam, B.; Ferrari, A.; Schoenmakers, E.; Duckett, K.; Leslie, J.; Romartinez-Alonso, B.; Tadross, J.; Jia, R.; Gardner, E.; Kentistou, K.; Zhao, Y.; Day, F.; Morseburg, A.; Rainbow, K.; Rimmington, D.; Mastantuoni, M.; Harrison, J.; Nus, M.; Guma'a, K.; Mayhew, S. S.; Jiang, X.; Smith, K. R.; Paul, D.; Jenkins, B.; Koulman, A.; Pietzner, M.; Langenberg, C.; Wareham, N.; Chatterjee, K.; Schwabe, J.; Oakley, F.; Mann, D.; Tontonoz, P.; Coll, T.; Ong, K. K.; Perry, J. R. B.; O'Rahilly, S.
10.1101/2024.04.28.591512 — genetics — Posted on 2024-04-29
293 Transcription of HIV-1 at sites of intact latent provirus integration
Teixeira, A. R.; Bittar, C.; Silva Santos, G. S.; Oliveira, T. Y.; Huang, A. S.; Linden, N.; Ferreira, I. A. T. M.; Murdza, T.; Muecksch, F.; Jones, R. B.; Caskey, M.; Jankovic, M.; Nussenzweig, M. C.
10.1101/2024.04.26.591331 — immunology — Posted on 2024-04-29
298 Drosophila Glue Expulsion and Spreading Behavior is Modulated by Neuropeptidergic Mip-SPR Signaling from a Descending Command Neuron
Fernandez-Acosta, M.; Zanini, R.; Heredia, F.; Volonte, Y.; Menezes, J.; Pruger, K.; Ibarra, J.; Arana, M.; Perez, M. S.; Veenstra, J. A.; Wegener, C.; Gontijo, A. M.; Garelli, A.
10.1101/2024.04.27.591209 — neuroscience — Posted on 2024-04-29
299 Information on Oral Temperature is More Robustly Encoded Than Taste in Neurons of the Mouse Gustatory Cortex
Nash, A. N.; Bouaichi, C. G.; Odegaard, K. E.; Needham, T.; Bauer, M.; Bertram, R.; Vincis, R.
10.1101/2024.04.27.591293 — neuroscience — Posted on 2024-04-29
300 Spinal cord perfusion impairments in the M83 mouse model of Parkinson's disease
Combes, B. F.; Kalva, S. K.; Benveniste, P.-L.; Tournant, A.; Law, M. H.; Newton, J.; Krueger, M.; Weber, R. Z.; Dias, I.; Noain, D.; Dean Ben, X. L.; Konietzko, U.; Baumann, C. R.; Gillberg, P.-G.; Hock, C.; Nitsch, R. M.; Cohen-Adad, J.; Razansky, D.; Ni, R.
10.1101/2024.04.27.591432 — neuroscience — Posted on 2024-04-29
303 Deciphering the Transcription Factor Landscape in Neuroendocrine Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation
Wang, Y.; Xue, H.; Zhu, X.; Lin, D.; Dong, X.; Chen, Z.; Chen, J.; Shi, M.; Ni, Y.; Cao, J.; Wu, R.; Kang, N.; Pang, X.; Crea, F.; Lin, Y.-Y.; Collins, C. C.; Gleave, M. E.; Parolia, A.; Chinnaiyan, A.; Ong, C. J.; Wang, Y.
10.1101/2024.04.27.591428 — cancer biology — Posted on 2024-04-29
304 MT-125 Inhibits Non-Muscle Myosin IIA and IIB, Synergizes with Oncogenic Kinase Inhibitors, and Prolongs Survival in Glioblastoma
Kenchappa, R.; Radnai, L.; Young, E. J.; Zarco, N.; Lin, L.; Dovas, A.; Meyer, C. T.; Haddock, A.; Hall, A.; Canoll, P. T.; Cameron, M.; Nagaiah, N. K.; Rumbaugh, G.; Griffin, P. R.; Kamenecka, T. M.; Miller, C. A.; Rosenfeld, S. S.
10.1101/2024.04.27.591399 — cancer biology — Posted on 2024-04-29
307 Topology-Driven Negative Sampling Enhances Generalizability in Protein-Protein Interaction Prediction
Chatterjee, A.; Ravandi, B.; Philip, N. H.; Abdelmessih, M.; Mowrey, W. R.; Ricchiuto, P.; Liang, Y.; Ding, W.; Mobarec, J. C.; Eliassi-Rad, T.
10.1101/2024.04.27.591478 — bioinformatics — Posted on 2024-04-29
308 A flexible fluid delivery system for rodent behavior experiments
Cruz, B. F.; Carrico, P.; Teixeira, L.; Freitas, S.; Mendes, F.; Bento, D.; Silva, A.
10.1101/2024.04.27.590287 — bioengineering — Posted on 2024-04-29
309 A new method for detecting mixed Mycobacterium tuberculosis infection and reconstructing constituent strains provides insights into transmission
Sobkowiak, B.; Cudahy, P.; Chitwood, M. H.; Clark, T. G.; Colijn, C.; Grandjean, L.; Walter, K. S.; Crudu, V.; Cohen, T.
10.1101/2024.04.26.591283 — genomics — Posted on 2024-04-29
315 Steep logarithmic increase of genetic variation in natural Arabidopsis thaliana accessions across geographic scales
Hesen, V.; Boele, Y.; Holmer, R.; Boesten, R.; Wijfjes, R.; Aarts, M. G. M.; van der Putten, W. H.; Scheres, B.; Willemsen, V.
10.1101/2024.04.26.591275 — genetics — Posted on 2024-04-29
317 Flipping the Script: Wolbachia Favoring Males in a Neotropical Drosophila
Moreira, M. M.; Dias, L. d. P. B.; Guzman, Y. C.; Sena, L. C. d. P.; de Almeida, J. P. P.; Yotoko, K.
10.1101/2024.04.26.591302 — evolutionary biology — Posted on 2024-04-29
321 Soil carbon in the world's tidal marshes
Maxwell, T. L.; Spalding, M. D.; Friess, D. A.; Murray, N. J.; Rogers, K.; Rovai, A. S.; Smart, L. S.; Weilguny, L.; Adame, M. F.; Adams, J. B.; Copertino, M. S.; Cott, G. M.; Duarte de Paula Costa, M.; Holmquist, J. R.; Ladd, C. J. T.; Lovelock, C.; Ludwig, M.; Moritsch, M. M.; Navarro, A.; Raw, J. L.; Ruiz-Fernandez, A.-C.; Serrano, O.; Smeaton, C.; Van de Broek, M.; Windham-Myers, L.; Landis, E.; Worthington, T. A.
10.1101/2024.04.26.590902 — ecology — Posted on 2024-04-29
329 Marmosets as model systems for the study of Alzheimers disease and related dementias: substantiation of physiological Tau 3R and 4R isoform expression and phosphorylation
Huhe, H.; Shapley, S. M.; Duong, D.; Wu, F.; Ha, S.-K.; Choi, S.-H.; Kofler, J.; Mou, Y.; Guimaraes, T. R.; Thathiah, A.; Schaeffer, L. K. H.; Carter, G. W.; Seyfried, N.; Silva, A. C.; Sukoff Rizzo, S. J.
10.1101/2024.04.26.590453 — systems biology — Posted on 2024-04-29
331 HD-ZIP IV genes are essential for embryo initial cell polarization in the radial axis initiation in Arabidopsis
Tanaka, S.; Matsushita, Y.; Hanaki, Y.; Higaki, T.; Kamamoto, N.; Matsushita, K.; Higashiyama, T.; Fujimoto, K.; Ueda, M.
10.1101/2024.04.27.588165 — plant biology — Posted on 2024-04-29
333 Etrinabdione (VCE-004.8), a B55a activator, promotes angiogenesis and arteriogenesis in critical limb ischemia.
Garcia-Martin, A.; Prados, M. E.; Lastres-Cubillo, I.; Ponce-Diaz-Martin, F. J.; Cerero, L.; Garrido-Rodriguez, M.; Navarrete, C.; Pineda, R.; Rodriguez, A. B.; Munoz, I.; Moya, J.; Medeot, A.; Moreno, J. A.; Chacon, A.; Garcia-Revillo, J.; Munoz, E.
10.1101/2024.04.26.591240 — pharmacology and toxicology — Posted on 2024-04-29
336 State of the Interactomes: an evaluation of molecular networks for generating biological insights
Wright, S. N.; Colton, S.; Schaffer, L. V.; Pillich, R. T.; Churas, C.; Pratt, D.; Ideker, T.
10.1101/2024.04.26.587073 — bioinformatics — Posted on 2024-04-29
339 Visualizing single-cell data with the neighbor embedding spectrum
Damrich, S.; Klockow, M. V.; Berens, P.; Hamprecht, F. A.; Kobak, D.
10.1101/2024.04.26.590867 — bioinformatics — Posted on 2024-04-29
341 Structural connectome changes in episodic migraine: the role of the cerebellum
Matoso, A.; Fouto, A. R.; Esteves, I.; Ruiz-Tagle, A.; Caetano, G.; da Silva, N. A.; Vilela, P.; Gil-Gouveia, R.; Nunes, R. G.; Figueiredo, P.
10.1101/2024.04.26.591265 — bioengineering — Posted on 2024-04-29
343 Advancing cooperative breeding research with a peer-reviewed and "live" Cooperative-Breeding Database (Co-BreeD)
Ben Mocha, Y.; Woith, M.; Drobniak, S. M.; Markman, S.; Frisoni, F.; Baglione, V.; Boersma, J.; Cousseau, L.; Covas, R.; Braga de Miranda, G. H.; Dey, C. J.; Doutrelant, C.; Gula, R.; Heinsohn, R.; Kingma, S. A.; Li, J.; Middleton, K.-M.; Radford, A.; Restrepo, C.; Rubenstein, D. R.; Schradin, C.; Theuerkauf, J.; Warrington, M. H.; Williams, D. A.; Woxvold, I. A.; Griesser, M.
10.1101/2024.04.26.591342 — animal behavior and cognition — Posted on 2024-04-29
345 Mimicking opioid analgesia in cortical pain circuits
James, J. G.; McCall, N. M.; Hsu, A. I.; Oswell, C. S.; Salimando, G. J.; Mahmood, M.; Wooldridge, L. M.; Wachira, M.; Jo, A.; Sandoval Ortega, R. A.; Wojick, J. A.; Beattie, K.; Farinas, S. A.; Chehimi, S. N.; Rodrigues, A.; Ejoh, L. L.; Kimmey, B. A.; Lo, E.; Azouz, G.; Vasquez, J. J.; Banghart, M. R.; Creasy, K. T.; Beier, K. T.; Ramakrishnan, C.; Crist, R. C.; Reiner, B. C.; Deisseroth, K.; Yttri, E. A.; Corder, G.
10.1101/2024.04.26.591113 — neuroscience — Posted on 2024-04-29
346 The muscarinic acetylcholine receptor in dermal papilla cells regulates hair growth
Yuen, G. K.-W.; Wu, K. Q.; Leung, K.-W.; Lai, Q. W.-S.; Xia, Y.; Guo, M. S.; Gao, X.; Ho, J. Y.-M.; Chu, H. C.-T.; Tsim, K. W.-K.
10.1101/2024.04.26.591334 — neuroscience — Posted on 2024-04-29
347 Delving into the claustrum: insights into memory formation, stabilization and updating in mice
Medina, C.; Ojea Ramos, S.; Depino, A. M.; Romano, A. G.; Krawczyk, M. C.; Boccia, M. M.
10.1101/2024.04.26.591314 — neuroscience — Posted on 2024-04-29
348 Variation in the Distribution of Large-scale Spatiotemporal Patterns of Activity Across Brain States
Meyer-Baese, L.; Anumba, N.; Bolt, T. S.; Daley, L.; LaGrow, T. J.; Zhang, X.; Xu, N.; Pan, W.-J.; Schumacher, E. H.; Keilholz, S.
10.1101/2024.04.26.591295 — neuroscience — Posted on 2024-04-29
351 Florigen-producing cells express FPF1-LIKE PROTEIN 1 that accelerates flowering and stem growth in long days with sunlight red/far-red ratio in Arabidopsis
Takagi, H.; Lee, N.; Hempton, A. K.; Purushwani, S.; Notaguchi, M.; Yamauchi, K.; Shirai, K.; Kawakatsu, Y.; Uehara, S.; Albers, W. G.; Downing, B. L. R.; Ito, S.; Suzuki, T.; Matsuura, T.; Mori, I. C.; Mitsuda, N.; Kurihara, D.; Matsushita, T.; Song, Y. H.; Sato, Y.; Nomoto, M.; Tada, Y.; Hanada, K.; Cuperus, J.; Queitsch, C.; Imaizumi, T.
10.1101/2024.04.26.591289 — plant biology — Posted on 2024-04-29
353 A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies
Chicca, A.; Batora, D.; Ullmer, C.; Caruso, A.; Fingerle, J.; Hartung, T.; Degen, R.; Mueller, M.; Grether, U.; Pacher, P.; Gertsch, J.
10.1101/2024.04.26.591311 — pharmacology and toxicology — Posted on 2024-04-29
354 To be or not to be - Decoding the Trabecular Meshwork Cell Identity
Tian, A.; Baidouri, H.; Kim, S.; Li, J.; Cheng, X.; Li, Y.; Chen, R.; Raghunathan, V.
10.1101/2024.04.26.591346 — genomics — Posted on 2024-04-29
355 Temporal dynamics and biogeography of sympagic and planktonic autotrophic microbial eukaryotes during the under-ice Arctic bloom
Sim, C. W. H.; Ribeiro, C. G.; Le Gall, F.; Probert, I.; Gourvil, P.; Lovejoy, C.; Vaulot, D.; Lopes dos Santos, A.
10.1101/2024.04.26.591324 — ecology — Posted on 2024-04-29
357 Order among chaos: high throughput MYCroplanters can distinguish interacting drivers of host infection in a highly stochastic system
Chen, M. Y.; Fulton, L.; Huang, I.; Liman, A.; Hossain, S.; Hamilton, C.; Song, S.; Geissmann, Q.; King, K. C.; Haney, C. H.
10.1101/2024.04.26.590795 — ecology — Posted on 2024-04-29
358 Cell wall-mediated maternal control of apical-basal patterning of the kelp Undaria pinnatifida
Dries, E.; Meyers, Y.; Liesner, D.; Gonzaga, F.; Becker, J.; Zakka, E. E.; Beeckman, T.; Coelho, S. M.; De Clerck, O.; Bogaert, K. A.
10.1101/2024.04.26.591308 — developmental biology — Posted on 2024-04-29
359 Flotillin-2 dampens T cell antigen-sensitivity and functionality
Moon, S.; Zhao, F.; Uddin, M.; Tucker, C. J.; Karmaus, P. W. F.; Fessler, M. B.
10.1101/2024.04.26.591344 — immunology — Posted on 2024-04-29
361 pNet: A toolbox for personalized functional networks modeling
Ma, Y.; Li, H.; Zhou, Z.; Chen, X.; Ma, L.; Guray, E.; Balderston, N. L.; Oathes, D. J.; Shinohara, R. T.; Wolf, D. H.; Nasrallah, I. M.; Shou, H.; Satterthwaite, T. D.; Davatzikos, C.; Fan, Y.
10.1101/2024.04.26.591367 — neuroscience — Posted on 2024-04-29
364 A morphology and secretome map of pyroptosis
Lippincott, M. J.; Tomkinson, J.; Bunten, D.; Mohammadi, M.; Kastl, J.; Knop, J.; Schwandner, R.; Huang, J.; Ongo, G.; Robichaud, N.; Dagher, M.; Tsuboi, M.; Basualto-Alarcon, C.; Way, G. P.
10.1101/2024.04.26.591386 — systems biology — Posted on 2024-04-29
365 Mechanisms Of Meristem Maintenance By Maize Transcriptional Corepressors
Gregory, J.; Liu, X.; Chen, Z.; Gallardo, C.; Punskovsky, J.; Koslow, G.; Galli, M.; Gallavotti, A.
10.1101/2024.04.26.591374 — plant biology — Posted on 2024-04-29
368 Genetic Deletion of Calcium-independent Phospholipase A2γ Protects Mice from Diabetic Nephropathy
Cybulsky, A. V.; Papillon, J.; Guillemette, J.; Navarro-Betancourt, J. R.; Elimam, H.; Fantus, I. G.
10.1101/2024.04.26.591364 — pathology — Posted on 2024-04-29
369 Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors
Muley Vilamu, H.; Dowdy, T.; Zaibaq, F.; Karadimov, G.; Li, A.; Song, H.; Zhang, M.; Zhang, W.; Wong, Z.; Zhang, L.; Lita, A.; Larion, M.
10.1101/2024.04.27.591426 — cancer biology — Posted on 2024-04-29
371 EYE-Llama, an in-domain large language model for ophthalmology
haghighi, t.; Gholami, S.; Sokol, J. T.; Kishnani, E.; Ahsaniyan, A.; Rahmanian, H.; Hedayati, F.; Leng, T.; Alam, M. N.
10.1101/2024.04.26.591355 — bioengineering — Posted on 2024-04-29
372 First whole genome assembly of Vaccinium floribundum Kunth, an emblematic Andean species
Albuja-Quintana, M.; Pozo, G.; Gordillo-Romero, M.; Armijos, C. E.; Torres, M. d. L.
10.1101/2024.04.26.591377 — genomics — Posted on 2024-04-29
373 High-resolution detection of copy number alterations in single cells with HiScanner
Zhao, Y.; Luquette, L. J.; Veit, A. D.; Wang, X.; Xi, R.; Viswanadham, V. V.; Shao, D. D.; Walsh, C. A.; Yang, H. W.; Johnson, M. D.; Park, P. J.
10.1101/2024.04.26.587806 — genomics — Posted on 2024-04-29
375 Ancestral sequence reconstruction of Mic60 reveals a residue signature supporting respiration in yeast
Benning, F. M. C.; Bell, T. A.; Nguyen, T. H.; Syau, D.; Connell, L. B.; daCosta, C. J. B.; Chao, L. H.
10.1101/2024.04.26.591372 — evolutionary biology — Posted on 2024-04-29
377 CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Variant
Kaplan, S. J.; Wong, W.; Yan, J.; Pulecio, J.; Cho, H.; Leslie-Iyer, J.; Kazakov, J.; Zhao, J.; Li, Q.; Murphy, D.; Luo, R.; Dey, K. K.; Apostolou, E.; Lesie, C. S.; Huangfu, D.
10.1101/2024.04.26.591412 — developmental biology — Posted on 2024-04-29
378 Reduced Levels of Lagging Strand Polymerases Shape Stem Cell Chromatin
Snedeker, J.; Davis, B. E. M.; Ranjan, R.; Wooten, M. I.; Blundon, J.; Chen, X.
10.1101/2024.04.26.591383 — developmental biology — Posted on 2024-04-29
380 Endothelial SHP-1 regulates diabetes-induced abnormal collateral vessel formation and endothelial cell senescence
Nadeau, A.; Ouellet, M.; Beland, R.; Mercier, C.; Robillard, S.; Lizotte, F.; Despatis, M.-A.; Benzinger, C. F.; Geraldes, P.
10.1101/2024.04.26.591415 — cell biology — Posted on 2024-04-29
381 ZNF574 is a Quality Control Factor For Defective Ribosome Biogenesis Intermediates
Akers, J.; Bothe, A.; Suh, H.; Jung, C.; Stolp, Z.; Ghosh, T.; Yan, L.; Wang, Y.; Grismer, T.; Reyes, A.; Hu, T.; Xu, S.; Ban, N.; Kostova, K.
10.1101/2024.04.26.591394 — cell biology — Posted on 2024-04-29
382 Stress granule induction in rat retinas damaged by constant LED light.
Benedetto, M. M.; Malcolm, M.; Bruera, M. G.; Penazzi, L. G.; Guido, M. E.; Contin, M. A.; Garbarino-Pico, E.
10.1101/2024.04.26.591385 — cell biology — Posted on 2024-04-29
384 5-HT Neurons Integrate GABA and Dopamine Inputs to Regulate Meal Initiation
Conde, K.; Wong, H.; Fang, S.; Li, Y.; Yu, M.; Deng, Y.; Liu, Q.; Fang, X.; Wang, M.; Shi, Y.; Ginnard, O. G.; Yang, Y.; Tu, L.; Liu, H.; Liu, H.; Yin, N.; Bean, J. C.; Han, J.; Burt, M. E.; Jossy, S. V.; Yang, Y.; Tong, Q.; Arenkiel, B.; Wang, C.; He, Y.; Xu, Y.
10.1101/2024.04.26.591360 — neuroscience — Posted on 2024-04-29
385 A comparative analysis of Parkinson's disease and inflammatory bowel disease gut microbiomes highlights shared depletions in key butyrate-producing bacteria
Krueger, M. E.; Boles, J. S.; Simon, Z. D.; Alvarez, S. D.; McFarland, N. R.; Okun, M. S.; Zimmermann, E. M.; Forsmark, C. E.; Tansey, M. G.
10.1101/2024.04.26.591350 — neuroscience — Posted on 2024-04-29
386 Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1
Zeng, T.; Jiang, T.; Zhang, B.; Zhang, T.; Dai, W.; Yin, X.; Li, Y.; Wu, C.; Wu, Y.; Chi, X.; Deng, X.; Wang, H.-R.
10.1101/2024.04.26.591418 — cancer biology — Posted on 2024-04-29
388 Targeting circadian transcriptional programs in triple negative breast cancer through a cis-regulatory mechanism
Pan, Y.; Chiu, T.-P.; Zhou, L.; Chan, P.; Kuo, T. T.; Battaglin, F.; Soni, S.; Lenz, H.-J.; Jayachandra, P.; Li, J. J.; Mumenthaler, S.; Rohs, R.; Roussos Torres, E.; Kay, S. A.
10.1101/2024.04.26.590360 — cancer biology — Posted on 2024-04-29
389 CoVAMPnet: Comparative Markov State Analysis for Studying Effects of Drug Candidates on Disordered Biomolecules
Marques, S. M.; Kouba, P.; Legrand, A.; Sedlar, J.; Disson, L.; Planas-Iglesias, J.; Sanusi, Z.; Kunka, A.; Damborsky, J.; Pajdla, T.; Prokop, Z.; Mazurenko, S.; Sivic, J.; Bednar, D.
10.1101/2023.01.06.523007 — biophysics — Posted on 2024-04-29
391 Structural analysis of S-ring composed of FliFG fusion proteins in marine Vibrio polar flagellar motors
Takekawa, N.; Nishikino, T.; Kishikawa, J.-i.; Hirose, M.; Kinoshita, M.; Kojima, S.; Minamino, T.; Uchihashi, T.; Kato, T.; Imada, K.; Homma, M.
10.1101/2024.04.26.591406 — biophysics — Posted on 2024-04-29
394 Loop Catalog: a comprehensive HiChIP database of human and mouse samples
Reyna, J.; Fetter, K.; Ignacio, R.; Ali Marandi, C. C.; Rao, N.; Jiang, Z.; Figueroa, D. S.; Bhattacharyya, S.; Ay, F.
10.1101/2024.04.26.591349 — bioinformatics — Posted on 2024-04-29
396 GENA-Web - GENomic Annotations Web Inference using DNA language models
Shmelev, A.; Petrov, M.; Penzar, D.; Akhmetyanov, N.; Tavritskiy, M.; Mamontov, S.; Kuratov, Y.; Burtsev, M.; Kardymon, O.; Fishman, V.
10.1101/2024.04.26.591391 — bioinformatics — Posted on 2024-04-29
398 Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy
Zambo, B.; Edelweiss, E.; Morlet, B.; Negroni, L.; Pajkos, M.; Dosztanyi, Z.; Ostergaard, S.; Trave, G.; Laporte, J.; Gogl, G.
10.1101/2023.02.14.528471 — biochemistry — Posted on 2024-04-29
402 Loss of spontaneous vasomotion precedes impaired cerebrovascular reactivity and microbleeds in a mouse model of cerebral amyloid angiopathy
Kozberg, M. G.; Munting, L. P.; Maresco, L. H.; Auger, C. A.; van den Berg, M. L.; Denis de Senneville, B.; Hirschler, L.; Warnking, J. M.; Barbier, E. L.; Farrar, C. T.; Greenberg, S. M.; Bacskai, B.; van Veluw, S. J.
10.1101/2024.04.26.591414 — neuroscience — Posted on 2024-04-29
404 Assembly, comparative analysis, and utilization of a single haplotype reference genome for soybean
Espina, M. J. C.; Lovell, J. T.; Jenkins, J. W.; Shu, S.; Sreedasyam, A.; Jordan, B. D.; Webber, j.; Boston, L.; Bruna, T.; Talag, J.; Goodstein, D. M.; Grimwood, J.; Stacey, G.; Cannon, S. B.; Lorenz, A.; Schmutz, J.; Stupar, R. M.
10.1101/2024.04.26.591401 — plant biology — Posted on 2024-04-29
406 Conservation of cortical crowding distance across individuals in human V4
Kurzawski, J. W.; Qiu, B. S.; Majaj, N. J.; Benson, N. C.; Pelli, D.; Winawer, J.
10.1101/2024.04.03.587977 — neuroscience — Posted on 2024-04-29
409 Multifaceted effects of variable biotic interactions on population stability in complex interaction webs
Hashimoto, K.; Hayasaka, D.; Eguchi, Y.; Seko, Y.; Cai, J.; Suzuki, K.; Goka, K.; Kadoya, T.
10.1101/2021.12.07.471695 — ecology — Posted on 2024-04-29
411 Australian vertebrate hosts of Japanese encephalitis virus; a review of the evidence
Moore, K. T.; Mangan, M. J.; Linnegar, B.; Athni, T. S.; McCallum, H. I.; Trewin, B. J.; Skinner, E.
10.1101/2024.04.23.590833 — ecology — Posted on 2024-04-29
413 Genetically encoded reporters of actin filament organization in living cells and tissues
Silva Martins, C.; Iv, F.; Kumar Suman, S.; Panagiotou, T. C.; Sidor, C.; Ruso-Lopez, M.; Plancke, C. N.; Omi, S.; Gomes, M.; Llewellyn, A.; Bandi, S. R.; Ramond, L.; Arbizzani, F.; Rimoli, C. V.; Schnorrer, F.; Robin, F.; Wilde, A.; LeGoff, L.; Pedelacq, J.-D.; Cabantous, S.; Rincon, S. A.; Chandre, C.; Brasselet, S.; Mavrakis, M.
10.1101/2024.04.26.591305 — cell biology — Posted on 2024-04-29
414 Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms
Nadimpalli, H. P.; Katsioudi, G.; Arpa, E. S.; Chikhaoui, L.; Arpat, A. B.; Liechti, A.; Palais, G.; Tessmer, C.; Hofmann, I.; Galy, B.; Gatfield, D.
10.1101/2023.10.23.563593 — molecular biology — Posted on 2024-04-29
415 Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling
Luksch, H.; Schulze, F.; Geissler-Lösch, D.; Sprott, D.; Höfs, L.; Szegö, E. M.; Tonnus, W.; Winkler, S.; Günther, C.; Linkermann, A.; Behrendt, R.; Teichmann, L. L.; Falkenburger, B. H.; Rösen-Wolff, A.
10.1101/2024.04.25.591149 — immunology — Posted on 2024-04-29
416 A multi-organ map of the human immune system across age, sex and ethnicity
Mangiola, S.; Milton, M.; Ranathunga, N.; LiWaiSuen, C.; Odainic, A.; Yang, E.; Hutchison, W.; Garnham, A.; Iskander, J.; Pal, B.; Yadav, V. J.; Rossello, F.; Carey, V.; Kallies, A.; Bedoui, S.; Morgan, M.; Papenfuss, A. T.
10.1101/2023.06.08.542671 — immunology — Posted on 2024-04-29
417 Spontaneous human CD8 T cell and EAE-inducible human CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive MS PBMC humanized mice
Papazian, I.; Kourouvani, M.; Dagkonaki, A.; Gouzouasis, V.; Dimitrakopoulou, L.; Markoglou, N.; Badounas, F.; Tselios, T.; Anagnostouli, M.; Probert, L.
10.1101/2023.06.07.543414 — immunology — Posted on 2024-04-29
418 Nutritional state-dependent modulation of Insulin-Producing Cells in Drosophila
Singh Bisen, R.; Iqbal, F. M.; Cascino-Milani, F.; Bockemühl, T.; Ache, J. M.
10.1101/2024.04.24.590939 — neuroscience — Posted on 2024-04-29
419 Blind but alive - congenital loss of atoh7 disrupts the visual system of adult zebrafish.
Hammer, J.; Roeppenack, P.; Yousuf, S.; Machate, A.; Fischer, M.; Hans, S.; Brand, M.
10.1101/2024.04.23.590799 — neuroscience — Posted on 2024-04-29
420 Sequential replacement of PSD95 subunits in postsynaptic supercomplexes is slowest in the cortex.
Morris, K.; Bulovaite, E.; Kaizuka, T.; Schnorrenberg, S.; Adams, C.; Komiyama, N.; Mendive-Tapia, L.; Grant, S. G. N.; Horrocks, M. H.
10.1101/2023.07.13.548866 — neuroscience — Posted on 2024-04-29
423 A change in the cell wall status initiates the elimination of the nucellus in Arabidopsis
Xu, W.; Gomez-Paez, D.-M.; Choinard, S.; Iannaccone, M.; Maricchiolo, E.; Peaucelle, A.; Voxeur, A.; Haas, K.; Pompa, A.; Magnani, E.
10.1101/2024.04.23.590775 — plant biology — Posted on 2024-04-29
424 RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway
Huang, F.; Dai, Z.; Yu, J.; Wang, K.; Chen, C.; Chen, D.; Zhang, J.; Zhao, J.; Zhang, W.; Qi, Y.; Wang, Y.; Li, X.; Li, M.
10.1101/2024.01.03.574004 — cancer biology — Posted on 2024-04-29
426 Repix: reliable, reusable, versatile chronic Neuropixels implants using minimal components
Horan, M.; Regester, D.; Mazuski, C.; Jahans-Price, T.; Bailey, S.; Thompson, E. J.; Slonina, Z.; Plattner, V.; Menichini, E.; Toksoz, I.; Pinto, S. R.; Burrell, M.; Varsavsky, I.; Dalgleish, H. W. P.; Bimbard, C.; Lebedeva, A.; Bauza, M.; Cacucci, F.; Wills, T.; Akrami, A.; Krupic, J.; Stephenson-Jones, M.; Barry, C.; Burgess, N.; O'Keefe, J.; Isogai, Y.
10.1101/2024.04.25.591118 — neuroscience — Posted on 2024-04-29
428 Benefits and Limits of Phasing Alleles for Network Inference of Allopolyploid Complexes
Tiley, G. P.; Crowl, A. A.; Manos, P. S.; Sessa, E. B.; Solis-Lemus, C.; Yoder, A. D.; Burleigh, J. G.
10.1101/2021.05.04.442457 — evolutionary biology — Posted on 2024-04-28
429 Missing Wedge Completion via Unsupervised Learning with Coordinate Networks
Van Veen, D.; Galaz-Montoya, J. G.; Shen, L.; Baldwin, P.; Chaudhari, A. S.; Lyumkis, D.; Schmid, M. F.; Chiu, W.; Pauly, J.
10.1101/2024.04.12.589090 — molecular biology — Posted on 2024-04-28
430 Polysaccharide breakdown products drive degradation-dispersal cycles of foraging bacteria through changes in metabolism and motility
Stubbusch, A. K. M.; Keegstra, J. M.; Schwartzman, J.; Pontrelli, S.; Clerc, E. E.; Charlton, S.; Stocker, R.; Magnabosco, C.; Schubert, O. T.; Ackermann, M.; D'Souza, G. G.
10.1101/2023.07.14.548877 — microbiology — Posted on 2024-04-28
433 A genetic and microscopy toolkit for live imaging of whole-body regeneration in Macrostomum lignano
Hall, R. N.; Li, H.; Chai, C.; Vermeulen, S.; Rio, R.; Song, E. S.; Gibson, J.; Prakash, M.; Fire, A. Z.; Wang, B.
10.1101/2024.04.28.590365 — bioengineering — Posted on 2024-04-28
434 Design principles to tailor Hsp104 therapeutics
Lin, J.; Carman, P. J.; Gambogi, C. W.; Kendsersky, N. M.; Chuang, E.; Gates, S. N.; Yokom, A. L.; Rizo, A. N.; Southworth, D. R.; Shorter, J.
10.1101/2024.04.26.591398 — bioengineering — Posted on 2024-04-28
436 Novel sulfatase cancer therapeutics negatively impact Bacteroidota of the colonic microbiota in a non-sulfatase dependent manner
cartmell, A.; Crawford, C. J.; Gunawan, C.; Chen, Z.; Byrne, D. P.; Darby, C.; Luis, A. S. J.; Elli, S.; Yates, E. A.; Bolam, D. N.; van der Post, S.; Williams, S. J.
10.1101/2024.04.27.591440 — biochemistry — Posted on 2024-04-28
437 Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells
Zhang, N.; Gao, S.; Peng, H.; Wu, J.; Li, H.; Gibson, C.; Wu, S.; Zhu, J.; Zheng, Q.
10.1101/2024.04.27.591460 — biochemistry — Posted on 2024-04-28
439 Population genomic analysis reveals cryptic population structure in the commercially important Lake Malawi cichlid Copadichromis mloto
Sawasawa, W.; van Huysduynen, A. H.; Gresham, S.; Sungani, H.; Rusuwa, B.; De Boeck, G.; Turner, G. F.; Ngochera, M.; Svardal, H.
10.1101/2024.04.26.591058 — genomics — Posted on 2024-04-28
440 Response of protein coding genes and microRNAs to temperature changes in four insect species
Tsang, S. S. K.; Nong, W.; Xie, Y.; Qu, Z.; Yip, H. Y.; Gaitan-Espitia, J. D.; Tai, A. P. K.; Yeung, Y. Y.; Tobe, S. S.; Bendena, W. G.; Hui, J. H. L.
10.1101/2024.04.28.591511 — molecular biology — Posted on 2024-04-28
442 Unlocking Antarctic molecular time-capsules - recovering historical environmental DNA from museum-preserved sponges
Jeunen, G.-J.; Mills, S.; Lamare, M.; Duffy, G. A.; Knapp, M.; Stanton, J.-A. L.; Mariani, S.; Treece, J.; Ferreira, S.; Duran-Vinet, B.; Zavodna, M.; Gemmell, N.
10.1101/2024.04.28.591519 — molecular biology — Posted on 2024-04-28
445 Skin-associated Corynebacterium amycolatum shares cobamides
Swaney, M. H.; Henriquez, N.; Campbell, T.; Handelsman, J.; Kalan, L.
10.1101/2024.04.28.591522 — microbiology — Posted on 2024-04-28
449 A Comparison of Techniques to Determine Active Motor Threshold for Transcranial Magnetic Stimulation Research
Beausejour, J. P.; Rusch, J.; Knowles, K. S.; Pagan, J. I.; Chaput, M.; Norte, G. E.; DeFreitas, J. M.; Stock, M. S.
10.1101/2024.04.19.590327 — neuroscience — Posted on 2024-04-28
450 Tools for comprehensive reconstruction and analysis of a female Drosophila ventral nerve cord
Azevedo, A. W.; Lesser, E.; Mark, B.; Phelps, J. S.; Elabbady, L.; Kuroda, S.; Sustar, A. E.; Moussa, A. J.; Kandelwal, A.; Dallmann, C. J.; Agrawal, S.; Lee, S.-Y. J.; Pratt, B. G.; Cook, A.; Skutt-Kakari, K.; Gerhard, S.; Lu, R.; Kemnitz, N.; Lee, K.; Halageri, A.; Castro, M.; Ih, D.; Gager, J.; Tammam, M.; Dorkenwald, S.; Collman, F. C.; Schneider-Mizell, C. M.; Brittain, D.; Jordan, C. S.; Dickinson, M. H.; Pacureanu, A.; Seung, H. S.; Macrina, T.; Lee, W.-C. A.; Tuthill, J. C.
10.1101/2022.12.15.520299 — neuroscience — Posted on 2024-04-28
452 Multi-day Neuron Tracking in High Density Electrophysiology Recordings using EMD
Yuan, A. X.; Colonell, J. I.; Lebedeva, A.; Okun, M.; Charles, A.; Harris, T. D.
10.1101/2023.08.03.551724 — neuroscience — Posted on 2024-04-28
454 CRISPR-GPT: An LLM Agent for Automated Design of Gene-Editing Experiments
Qu, Y.; Huang, K.; Cousins, H.; Johnson, W. A.; Yin, D.; Shah, M. M.; Zhou, D.; Altman, R. B.; Wang, M.; Cong, L.
10.1101/2024.04.25.591003 — bioinformatics — Posted on 2024-04-28
455 Extracellular release of damaged mitochondria induced by pre-hematopoietic stem cell transplant conditioning exacerbates graft-versus-host disease
Vijayan, V.; Yan, H.; Lohmeyer, J. K.; Prentiss, K. A.; Patil, R. V.; Barbarito, G.; Lopez, I.; Elezaby, A.; Peterson, K.; Baker, J.; Ostberg, N. P.; Bertaina, A.; Negrin, R. S.; Mochly-Rosen, D.; Weinberg, K.; Haileselassie, B.
10.1101/2023.04.24.538141 — immunology — Posted on 2024-04-28
456 Synaptic architecture of leg and wing premotor control networks in Drosophila
Lesser, E.; Azevedo, A. W.; Phelps, J. S.; Elabbady, L.; Cook, A. P.; Sakeena Syed, D.; Mark, B.; Kuroda, S.; Sustar, A.; Moussa, A. J.; Dallmann, C. J.; Agrawal, S.; Lee, S.-Y. J.; Pratt, B. G.; Skutt-Kakari, K.; Gerhard, S.; Lu, R.; Kemnitz, N.; Lee, K.; Halageri, A.; Castro, M.; Ih, D.; Gager, J.; Tammam, M.; Dorkenwald, S.; Collman, F. C.; Schneider-Mizell, C. M.; Brittain, D.; Jordan, C. S.; Macrina, T.; Dickinson, M. H.; Lee, W.-C. A.; Tuthill, J. C.
10.1101/2023.05.30.542725 — neuroscience — Posted on 2024-04-28
458 Direct and indirect regulation of β- glucocerebrosidase by the transcription factors USF2 and ONECUT2
Aguzzi, A.; Yin, J.-A.; Vocadlo, D. J.; Ging, K.; Lukas, F.; Zhu, Y.; Schlachetzki, J.; Gilormini, P.-A.; Chen, X.; Boeck, D.; Serdiuk, T.; Marques, A.; Pisano, C.; Trevisan, C.; Sellitto, S.; Deen, M.; Armani, A.; Dhingra, A.; Glass, C.; Heutink, P.
10.1101/2024.04.28.591482 — molecular biology — Posted on 2024-04-28
460 Post-mortem evidence for a reciprocal relationship between genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies.
Koss, D. J.; Todd, O. J. G.; Menon, H.; Anderson, Z. A.; Yang, T.; Attems, J.; LeBeau, F. E.; Erskine, D.; Outeiro, T. F.
10.1101/2024.04.24.590825 — neuroscience — Posted on 2024-04-28
461 Self-Assembled Origami Neural Probes for Scalable, Multifunctional, Three-Dimensional Neural Interface
Yan, D.; Ruiz, J. R. L.; Hsieh, M.-L.; Jeong, D.; Voroslakos, M.; Lanzio, V.; Warner, E. V.; Ko, E.; Tian, Y.; Patel, P. R.; ElBidweihy, H.; Smith, C. S.; Lee, J.-H.; Cheon, J.; Buzsaki, G.; Yoon, E.
10.1101/2024.04.25.591141 — neuroscience — Posted on 2024-04-28
466 Cell Simulation as Cell Segmentation
Jones, D. C.; Elz, A. E.; Hadadianpour, A.; Ryu, H.; Glass, D. R.; Newell, E. W.
10.1101/2024.04.25.591218 — bioinformatics — Posted on 2024-04-28
467 Equilibrium Tension and Compression Mechanical Properties of the Human Uterus
Fang, S.; Duarte-Cordon, C. A.; Fodera, D. M.; Shi, L.; Chen, X.; Advincula, A. P.; Vink, J.; Hendon, C. P.; Myers, K. M.
10.1101/2024.04.25.591208 — bioengineering — Posted on 2024-04-28
468 Coastal oceanographic connectivity estimates at the global scale
Assis, J.; Legrand, T.; Fragkopoulou, E.; Serrao, E. A.; Araujo, M.
10.1101/2024.04.24.590881 — ecology — Posted on 2024-04-28
469 BRWD1 establishes epigenetic states for germinal center initiation, maintenance, and function
Wright, N. E.; Kennedy, D. E.; Ai, J.; Veselits, M. L.; Attaway, M.; Yoon, Y. m.; Durkee, M. S.; Veselits, J.; Maienschein-Cline, M.; Mandal, M.; Clark, M. R.
10.1101/2024.04.25.591154 — immunology — Posted on 2024-04-28
471 Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
Golden, G. J.; Wu, V. H.; Hamilton, J. T.; Amses, K. R.; Shapiro, M. R.; Japp, A. S.; Liu, C.; Pampena, M. B.; Kuri-Cervantes, L.; Knox, J. J.; Gardner, J. S.; HPAP Consortium, ; Atkinson, M. A.; Brusko, T. M.; Prak, E. T. L.; Kaestner, K. H.; Naji, A.; Michael, B. R.
10.1101/2024.04.23.590798 — immunology — Posted on 2024-04-28
474 Projection-TAGs enable multiplex projection tracing and multi-modal profiling of projection neurons
Yang, L.; Liu, F.; Hahm, H.; Okuda, T.; Li, X.; Zhang, Y.; Kalyanaraman, V.; Heitmeier, M. R.; Samineni, V. K.
10.1101/2024.04.24.590975 — neuroscience — Posted on 2024-04-28
475 Common neural mechanisms supporting time judgements in humans and monkeys
Rodriguez Larios, J.; Rassi, E.; Mendoza, G.; Merchant, H.; Haegens, S.
10.1101/2024.04.25.591075 — neuroscience — Posted on 2024-04-28
476 Linking phenology, harvest index and genetics to improve chickpea grain yield
Gimenez, R.; Lake, L. S.; Cossani, C. M.; Ortega Martinez, R.; Hayes, J.; Dreccer, M. F.; French, R.; Weller, J.; Sadras, V. O.
10.1101/2024.04.23.590839 — plant biology — Posted on 2024-04-28
477 Worldwide study of the taste of bitter medicines and their modifiers
Nguyen, H.; Lin, C.; Bell, K.; Huang, A.; Hannum, M.; Ramirez, V.; Christensen, C.; Rawson, N.; Colquitt, L.; Domanico, P.; Sasimovich, I.; Herriman, R.; Joseph, P. V.; Braimah, O.; Reed, D. R.
10.1101/2024.04.24.590957 — physiology — Posted on 2024-04-28
482 Chemical Coverage of the Human Reactome
Kwak, H. A.; Liu, L.; Tredup, C.; Röhm, S.; Prinos, P.; Böttcher, J.; Schapira, M.
10.1101/2024.04.23.590739 — bioinformatics — Posted on 2024-04-28
486 An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut
Nan, K.; Wong, K.; Li, D.; Ying, B.; McRae, J. C.; Feig, V. R.; Wang, S.; Yao, K.; Zhou, J.; Li, J.; Jenkins, J.; Ishida, K.; Kuosmanen, J.; Madani, W.; Hayward, A.; Ramadi, K.; Yu, X.; Traverso, G.
10.1101/2024.04.25.591220 — bioengineering — Posted on 2024-04-28
490 Recent adaptation in an imperiled salmonid revealed by museum genomics
Sharo, A. G.; Supple, M. A.; Cabrera, R.; Seligmann, W. E.; Sacco, S.; Columbus, C. D.; Pearse, D. E.; Shapiro, B.; Garza, J. C.
10.1101/2024.04.25.590849 — genomics — Posted on 2024-04-28
491 Taking advantage of reference-guided assembly in a slowly-evolving lineage: application to Testudo graeca.
MIRA-JOVER, A.; Gracia, E.; Giminez, A.; Fritz, U.; Rodriguez-Caro, R. C.; Bourgeois, Y.
10.1101/2024.04.25.591224 — genomics — Posted on 2024-04-28
500 Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis
Ziehr, D. R.; Li, F.; Parnell, K. M.; Krah, N. M.; Leahy, K. J.; Guillermier, C.; Varon, J.; Baron, R. M.; Maron, B. A.; Philp, N. J.; Hariri, L. P.; Kim, E. Y.; Steinhauser, M. L.; Knipe, R. S.; Rutter, J.; Oldham, W.
10.1101/2024.04.25.591150 — cell biology — Posted on 2024-04-28
501 ALTERATIONS IN PEROXISOMAL-MITOCHONDRIAL INTERPLAY IN SKELETAL MUSCLE ACCELERATES MUSCLE DYSFUNCTION
Scalabrin, M.; Turco, E.; Nogara, L.; Gherardi, G.; Trani, G.; Negro, S.; Franco Romero, A.; Jaspers, Y.; Baschiera, E.; De Cegli, R.; Del Prete, E.; Cali, T.; Blaauw, B.; Salviati, L.; Rigoni, M.; Mammucari, C.; Caspar-Bauguil, S.; Moro, C.; Sandri, M.; Kemp, S.; Romanello, V.
10.1101/2024.04.25.591056 — cell biology — Posted on 2024-04-28
502 Antibiotic-induced Malassezia spp. expansion in infants promotes early-life immune dysregulation and airway inflammation in mice
van Tilburg Bernardes, E.; Gutierrez, M. W.; Nguyen, W. N. T.; Mercer, E. M.; Ramay, H. R.; Glatthardt, T.; Thomson, C. A.; Halim, T.; Gopalakrishnan, N.; Kalbfleish, K.; Patel, K. D.; McCoy, K. D.; Freedman, S. B.; Arrieta, M. C.
10.1101/2024.04.24.590822 — immunology — Posted on 2024-04-28
503 Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity
Guillamot, M.; Subudhi, I.; Paraskevopoulou, V.; Prystupa, A.; Sidhu, I.; Yeaton, A.; Laskou, M.; Hannemann, C.; Donahoe, C.; Wiseman, D.; Aifantis, I.; Naik, S.; Weinstock, A.
10.1101/2024.04.24.590828 — immunology — Posted on 2024-04-28
504 Tumor-expressed SPPL3 supports innate anti-tumor immune responses.
Verkerk, T.; de Waard, A. A.; Koomen, S. J.; Sanders, J.; Jorritsma, T.; Pappot, A. T.; Zandhuis, N. D.; Zhang, T.; Wuhrer, M.; Stockinger, H. S. J.; van Gisbergen, K. P. J. M.; Spaapen, R. M.; van Ham, S. M.
10.1101/2024.04.25.591102 — immunology — Posted on 2024-04-28
507 Epithelial IL-2 is critical for NK cell-mediated cancer immunosurveillance in mammary glands
Wang, L.; Maharjan, C.; Borcherding, N.; Master, R. P.; Mo, j.; Tithi, T. I.; Carelock, M.; Master, A.; Gibson-Corley, K.; Kolb, R. H.; Smith, K. A.; Zhang, W.
10.1101/2024.04.25.591178 — immunology — Posted on 2024-04-28
508 Treg fitness as a biomarker for disease activity in Juvenile Idiopathic Arthritis
Attrill, M. H.; Shinko, D.; Viveiros, T. M.; Milighetti, M.; Gruijter, N. M.; Jebson, B.; Kartawinata, M.; Rosser, E. C.; Wedderburn, L. R.; CHARMS and JIAP Studies, ; Pesenacker, A. M.
10.1101/2024.04.24.590917 — immunology — Posted on 2024-04-28
509 Thrombospondins 1 and 4 undergo coordinated transport to multicore cytotoxic granules to regulate SMAP biogenesis and function in CTL-mediatedcytotoxicity
Cassioli, C.; Capitani, N.; Staton, C. C.; Schirra, C.; Finetti, F.; Onnis, A.; Alawar, N.; Tu, S.-M.; Lopresti, L.; Tatangelo, V.; Tangredi, C.; Valvo, S.; Chang, H.-F.; Miccoli, A.; Compeer, E. B.; Nicholls, J.; Blazar, B.; Marotta, G.; Wood, M. J.; Trentin, L.; Patrussi, L.; Dustin, M. L.; Becherer, U.; Baldari, C. T.
10.1101/2024.04.25.590546 — immunology — Posted on 2024-04-28
511 Protection against experimental cryptococcosis elicited by Cationic Adjuvant Formulation 01-adjuvanted subunit vaccines
Wang, R.; Oliveira, L. V. N.; Hester, M. M.; Carlson, D. M.; Christensen, D.; Specht, C. A.; Levitz, S. M.
10.1101/2024.04.24.591045 — immunology — Posted on 2024-04-28
512 SLAMF7 and SLAMF8 receptors shape human plasmacytoid dendritic cell responses to intracellular bacteria
Pellegrini, J. M.; Keriel, A.; Gorvel, L.; Hanniffy, S.; Arce-Gorvel, V.; Bosilkovski, M.; Solera, J.; Meresse, S.; MEMET, S.; Gorvel, J.-P.
10.1101/2024.04.25.591064 — immunology — Posted on 2024-04-28
516 High-dimensional proteomic analysis for pathophysiological classification of Traumatic Brain Injury
Li, L. M.; Kodosaki, E.; Heslegrave, A.; Zetterberg, H.; Graham, N.; Zimmerman, K. A.; Soreq, E.; Parker, T.; Garbero, E.; Moro, F.; Magnoni, S.; Bertolini, G.; Loane, D. J.; Sharp, D. J.
10.1101/2024.04.23.590636 — neuroscience — Posted on 2024-04-28
517 HSD2 neurons are evolutionarily conserved and required for aldosterone-induced salt appetite
Gasparini, S.; Peltekian, L.; McDonough, M. C.; Mitchell, C. J. A.; Hefti, M. M.; Resch, J. M.; Geerling, J. C.
10.1101/2024.04.24.590990 — neuroscience — Posted on 2024-04-28
518 Group social dynamics in a semi-natural setup reveal an adaptive value for aggression in male mice
Anpilov, S.; Shemesh, Y.; Benjamin, A.; Biagini, T.; Sztainberg, Y.; Richter-Levin, A.; Forkosh, O.; Chen, A.
10.1101/2024.04.25.591070 — neuroscience — Posted on 2024-04-28
519 Microstructural Mapping of Neural Pathways in Alzheimer's Disease using Macrostructure-Informed Normative Tractometry
Feng, Y.; Chandio, B. Q.; Villalon-Reina, J. E.; Thomopoulos, S. I.; Nir, T. M.; Benavidez, S.; Laltoo, E.; Chattopadhyay, T.; Joshi, H.; Venkatasubramanian, G.; John, J. P.; Jahanshad, N.; Reid, R. I.; Jack, C. R.; Weiner, M. M.; Thompson, P. M.; the Alzheimer's Disease Neuroimaging Initiative,
10.1101/2024.04.25.591183 — neuroscience — Posted on 2024-04-28
521 Optimal filtering strategies for task-specific functional PET imaging
Reed, M. B.; Ponce de Leon, M.; Klug, S.; Milz, C.; Silberbauer, L. R.; Falb, P.; Godbersen, G. M.; Jamadar, S.; Chen, Z.; Nics, L.; Hacker, M.; Lanzenberger, R.; Hahn, A.
10.1101/2024.04.25.591053 — neuroscience — Posted on 2024-04-28
525 Imaging demyelinated axons after spinal cord injuries with PET tracer 3F4AP
Ramos-Torres, K. M.; Conti, S.; Zhou, Y.-P.; Tiss, A.; Caravagna, C.; Takahashi, K.; He, M.; Wilks, M. Q.; Eckl, S.; Sun, Y.; Gong, K.; He, Z.; Linnman, C.; Brugarolas, P.
10.1101/2024.04.24.590984 — neuroscience — Posted on 2024-04-28
528 LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics
Shinozuka, K.; Tewarie, P.; Luppi, A.; Lynn, C.; Roseman, L.; Muthukumaraswamy, S. D.; Nutt, D. J.; Carhart-Harris, R.; Deco, G.; Kringelbach, M. L.
10.1101/2024.04.25.591130 — neuroscience — Posted on 2024-04-28
530 Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes
Al-Diwani, A.; Provine, N.; Murchison, A.; Laban, R.; Swann, O.; Koychev, I.; Sheerin, F.; Da Mesquita, S.; Heslegrave, A.; Zetterberg, H.; Klenerman, P.; Irani, S.
10.1101/2024.04.26.591238 — neuroscience — Posted on 2024-04-28
531 Spatial neglect after subcortical stroke: sometimes a cortico-cortical disconnection syndrome
Sperber, C.; Rosenzopf, H.; Wawrzyniak, M.; Klingbeil, J.; Saur, D.; Karnath, H.-O.
10.1101/2024.04.25.591066 — neuroscience — Posted on 2024-04-28
535 Socialization causes long-lasting behavioral changes
Gil-Marti, B.; Isidro-Mezcua, J.; Poza-Rodriguez, A.; Asti Tello, G. S.; Treves, G.; Das, A.; Turiegano, E.; Beckwith, E. J.; Martin, F. A.
10.1101/2024.04.25.591071 — neuroscience — Posted on 2024-04-28
539 Molecular surface chemistry defines nematode development, identity and behaviour
Kotowska, A. M.; Hiramatsu, F.; Alexander, M. R.; Scurr, D. J.; Lightfoot, J. W.; Chauhan, V. M.
10.1101/2024.04.24.590549 — systems biology — Posted on 2024-04-28
543 The nuclear sulfenome of Arabidopsis: spotlight on histone acetyltransferase GCN5 regulation through functional thiols
De Smet, B.; Yang, X.; Plskova, Z.; Castell, C.; Fernandez-Fernandez, A.; Dard, A.; Mhamdi, A.; Vertommen, D.; Chan, K. X.; Pyr dit Ruys, S.; Messens, J.; Kerchev, P. I.; Van Breusegem, F.
10.1101/2024.04.24.590918 — plant biology — Posted on 2024-04-28
548 StomaVision: stomatal trait analysis through deep learning
Wu, T.-L.; Chen, P.-Y.; Du, X.; Wu, H.; Ou, J.-Y.; Zheng, P.-X.; Wu, Y.-L.; Wang, R.-S.; Hsu, T.-C.; Lin, C.-Y.; Lin, W.-Y.; Chang, P.-L.; Ho, C.-M. K.; Lin, Y.-C.
10.1101/2024.04.24.590919 — plant biology — Posted on 2024-04-28
549 Pear (Pyrus communis L. cv. Conference) has shade-tolerant features allowing for consistent agrivoltaic crop yield
Reher, T.; Willockx, B.; Schenk, A.; Bisschop, J.; Huyghe, Y.; Nicolai, B.; Martens, J. A.; Diels, J.; Cappelle, J.; Van de Poel, B.
10.1101/2024.04.24.590973 — plant biology — Posted on 2024-04-28
550 A multidisciplinary on-farm survey of maize-bean intercropping shows that revival of traditionalagricultural systems requires careful consideration of partner varieties and agronomic practices.
Vazeux-Blumental, N.; Mathieu, L.; Trabac, T.; Palaffre, C.; Lagardere, B.; Carraretto, M.; Bauland, C.; Le Guilloux, M.; Paysant-Le Roux, C.; Caius, J.; Marmagne, A.; Enjalbert, J.; Flutre, T.; Le Cadre, E.; Parnaudeau, V.; Muller, D.; Moenne-Loccoz, Y.; Manicacci, D.; Tenaillon, M. I.
10.1101/2024.04.24.590929 — plant biology — Posted on 2024-04-28
553 Resource competition affects the developmental outcome of the acoustic parasitoid fly Ormia ochracea
Dominguez, J. A.; Latham, B.; Mongui, L. C.; Rossinow, A.; Xiong, Y.; Schmidt, B. V.; Vu, Q.; Torres-Lopez, B. L.; Hendserson, P. A.; Mason, A. C.; Lee, N.
10.1101/2024.04.25.590943 — physiology — Posted on 2024-04-28
556 PROSTATE CELL HETEROGENEITY AND CXCL17 UPREGULATION IN MOUSE STEROID HORMONE IMBALANCE
Silver, S. V.; Tucker, K. J.; Vickman, R. E.; Lanman, N. A.; Semmes, O. J.; Alvarez, N. S.; Popovics, P.
10.1101/2024.04.24.590980 — pathology — Posted on 2024-04-28
558 Two modes in the velocity statistics in cautious walks of laboratory rodents
Midzyanovskaya, I.; Rebik, A.; Idzhilova, O.; Strelkov, V.; Komarova, N.; Chichigina, O.
10.1101/2024.04.23.590757 — biophysics — Posted on 2024-04-28
562 Genome sequence and characterization of a hypervirulent BI/NAP1/027 Clostridioides difficile (CDC20121308)
Espanol, L. A.; Palumbo, M. C.; Barbero, A. M.; Palma, S.; Serral, F.; Ruggeri, D.; Marti, M. A.; Fernandez Do Porto, D.; Hernandez Del Pino, R. E.; Pasquinelli, V.
10.1101/2024.04.25.590960 — bioinformatics — Posted on 2024-04-28
565 Got meat? The mechanical signature of plant-based and animal meat
St. Pierre, S. R.; Darwin, E. C.; Adil, D.; Aviles, M. C.; Date, A. M.; Dunne, R.; Lall, Y.; Vallecillo, M. P.; Medina, V. A. P.; Linka, K.; Levenston, M. E.; Kuhl, E.
10.1101/2024.04.25.591207 — bioengineering — Posted on 2024-04-28
566 Iris Morphological and Biomechanical Factors Influencing Angle Closure During Pupil Dilation
Tan, R. K. Y.; Ng, G.; Tun, T. A.; Braeu, F. A.; Nongpiur, M. E.; Aung, T.; Girard, M. J. A.
10.1101/2024.04.24.591028 — bioengineering — Posted on 2024-04-28
569 Caspar determines primordial germ cell identity in Drosophila melanogaster
Das, S.; Hegde, S.; Wagh, N.; Sudhakaran, J.; Roy, A. E.; Deshpande, G.; Ratnaparkhi, G. S.
10.1101/2024.04.25.591132 — genetics — Posted on 2024-04-28
570 Identification of genetic bases of male fertility in Pyricularia oryzae by Genome Wide Association Study (GWAS).
Lassagne, A.; Adreit, H.; Malagnac, F.; Charriat, F.; Dumartinet, T.; Parrinello, H.; Gonzalez, A.-A.; Tharreau, D.; Fournier, E.
10.1101/2024.04.25.591152 — genetics — Posted on 2024-04-28
582 Tree Surface Area Allometry
Shenkin, A.; Wilkes, P.; Enquist, B. J.; Lau Sarmiento, A.; Burt, A.; Calders, K.; Raumonen, P.; Patrick Bentley, L.; Disney, M.; Malhi, Y.
10.1101/2024.04.23.590783 — ecology — Posted on 2024-04-28
588 Correlating Protein Aggregate Structure with Cellular Function in Differentiated Muscle Cells: Discriminating Pathogenic from Non-Pathogenic Forms
Mallon, S. D. D.; Bos, E.; Sheikhhassani, V.; Shademan, M.; Rocca, D.; Voortman, L. M.; Mashaghi, A. M.; Sharp, T.; raz, v.
10.1101/2024.04.25.591067 — cell biology — Posted on 2024-04-28
591 A proposed workflow to analyze bacterial transcripts in RNAseq from blood extracellular vesicles of people with Multiple Sclerosis
Ascension, A. M.; Gorostidi-Aicua, M.; Otaegui-Chivite, A.; Alberro, A.; Bravo-Miana, R. d. C.; Castillo-Trivino, T.; Moles, L.; Otaegui, D.
10.1101/2024.04.23.590754 — bioinformatics — Posted on 2024-04-28
598 CAIM: Coverage-based Analysis for Identification of Microbiome
Acheampong, D. A.; Jenjaroenpun, P.; Wongsurawat, T.; Krulilung, A.; Pomyen, Y.; Kunadirek, P.; Chuaypen, N.; Kusonmano, K.; Nookaew, I.
10.1101/2024.04.25.591018 — bioinformatics — Posted on 2024-04-28
599 CaClust: linking genotype to transcriptional heterogeneity of follicular lymphoma using BCR and exomic variants
Oksza-Orzechowski, K.; Quinten, E.; Shafighi, S. D.; Kiełbasa, S. M.; van Kessel, H.; de Groen, R. A. L.; Vermaat, J. S. P.; Sepluveda-Yanez, J. H.; Navarrete, M. A.; Veelken, H.; van Bergen, C. A. M.; Szczurek, E. M.
10.1101/2024.04.24.590966 — bioinformatics — Posted on 2024-04-28
600 Clustering Electrophysiological Predisposition to Binge Drinking: An Unsupervised Machine Learning analysis
Uceta, M.; Del Cerro-Leon, A.; Shpakivska-Bilan, D.; Garcia-Moreno, L. M.; Maestu, F.; Anton-Toro, L. F.
10.1101/2024.04.24.590901 — neuroscience — Posted on 2024-04-28
601 Genome Report: Pseudomolecule-scale genome assemblies of Drepanocaryum sewerzowii and Marmoritis complanata
Smit, S. J.; Whitehead, C.; James, S. R.; Jeffares, D. C.; Godden, G.; Peng, D.; Sun, H.; Lichman, B. R.
10.1101/2024.04.23.590777 — genomics — Posted on 2024-04-28
602 Missing cell types in single-cell references impact deconvolution of bulk data but are detectable
Ivich, A.; Davidson, N. R.; Grieshober, L.; Li, W.; Hicks, S. C.; Doherty, J. A.; Greene, C. S.
10.1101/2024.04.25.590992 — bioinformatics — Posted on 2024-04-28
603 A Multiresolution Approach with Method-Informed Statistical Analysis for Quantifying Lymphatic Pumping Dynamics
Razavi, M. S.; Ruscic, K. J.; Korn, E. G.; Marquez, M.; Houle, T. T.; Singhal, D.; Munn, L. L.; Padera, T. P.
10.1101/2024.04.24.590950 — physiology — Posted on 2024-04-28
605 Comparison of therapeutic effects between pulsed field ablation and cryoballoon ablation in the treatment of atrial fibrillation: a systematic review and me-ta-analysis
Wan, Y.; Yun Wan, ; Zeng, S.; Shuting Zeng, ; Liu, F.; Fuwei Liu, ; Gao, X.; xin Gao, ; Li, W.; Weidong Li, ; Liu, K.; Kaifeng Liu, ; He, J.; Jie He, ; Ji, J.; Jianqing Ji, ; Luo, J.
10.1101/2024.04.24.591020 — physiology — Posted on 2024-04-28
607 Rapid and Accurate Estimation of Genetic Relatedness Between Millions of Viral Genome Pairs Using MANIAC
Ndovie, W.; Havranek, J.; Koszucki, J.; Leconte, J.; Chindelevitch, L.; Adriaenssens, E. M.; Mostowy, R. J.
10.1101/2024.04.23.590796 — bioinformatics — Posted on 2024-04-28
608 Genome of tropical bed bug Cimex hemipterus (Cimicidae, Hemiptera) reveals tetraspanin expanded in bed bug ancestor
Law, S. T. S.; Nong, W.; Li, C.; Chong, T. K.; Yip, H. Y.; Swale, T.; Chiu, S. W.; Chung, R. Y.-N.; Lam, H.-M.; Wong, S. Y. S.; Wong, H.; Hui, J. H. L.
10.1101/2024.04.25.591052 — genomics — Posted on 2024-04-28
609 mastR: Marker Automated Screening Tool for multi-omics data
Chen, J.; Mohamed, A.; Bhuva, D. D.; Davis, M. J.; Tan, C. W.
10.1101/2024.04.24.590691 — bioinformatics — Posted on 2024-04-28
612 Perturbation-Specific Transcriptional Mapping facilitates unbiased target elucidation of antibiotics
Romano, K. P.; Bagnall, J.; Warrier, T.; Sullivan, J.; Ferrara, K.; Orzechowski, M.; Nguyen, P.; Raines, K.; Livny, J.; Shoresh, N.; Hung, D.
10.1101/2024.04.25.590978 — genomics — Posted on 2024-04-28
614 CENP-A/CENP-B uncoupling in the evolutionary reshuffling of centromeres
Cappelletti, E.; Piras, F. M.; Biundo, M.; Raimondi, E.; Nergadze, S. G.; Giulotto, E.
10.1101/2024.04.24.590946 — genomics — Posted on 2024-04-28
616 Combining EEG and Eye-Tracking in Virtual Reality - Obtaining Fixation-Onset ERPs and ERSPs
Nolte, D.; Vidal De Palol, M.; Keshava, A.; Madrid-Carvajal, J.; Gert, A. L.; von Butler, E.-M.; Kömürlüoglu, P.; König, P.
10.1101/2024.04.24.590885 — neuroscience — Posted on 2024-04-28
617 Screening great ape museum specimens for DNA viruses
Haemmerle, M.; Guellil, M.; Cheronet, O.; Sawyer, S.; Ruiz-Gartzia, I.; Lizano, E.; Rymbekova, A.; Gelabert, P.; Bernardi, P.; Han, S.; Trgovec-Greif, L.; Rattei, T.; Schuenemann, V. J.; Marques-Bonet, T.; Guschanski, K.; Calvignac-Spencer, S.; Pinhasi, R.; Kuhlwilm, M.
10.1101/2024.04.25.591107 — genomics — Posted on 2024-04-28
620 The Genome Explorer Genome Browser
Herson, J.; Krummenacker, M.; Spaulding, A.; O'Maille, P.; Karp, P. D.
10.1101/2024.04.24.590985 — bioinformatics — Posted on 2024-04-28
621 mRNA nuclear clustering leads to a difference in mutant huntingtin mRNA and protein silencing by siRNAs in vivo
Allen, S. J.; O'Reilly, D.; Miller, R.; Sapp, E.; Summers, A.; Paquette, J.; Moreno, D. E.; Bramato, B.; McHugh, N.; Yamada, K.; Aronin, N.; DiFiglia, M.; Khvorova, A.
10.1101/2024.04.24.590997 — neuroscience — Posted on 2024-04-28
625 Blind source separation of event-related potentials using a recurrent neural network
O'Reilly, J. A.; Sunthornwiriya-Amon, H.; Aparprasith, N.; Kittichalao, P.; Chairojwong, P.; Klai-on, T.; Lannon, E. W.
10.1101/2024.04.23.590794 — neuroscience — Posted on 2024-04-28
627 Exposure to light supresses the activity of the medial and superior amygdala during emotional processing
Campbell, I.; Balda, F.; Sharifpour, R.; Paparella, I.; Beckers, E.; Berger, A.; Koshmanova, E.; Mortazavi, N.; Read, J.; Phillips, C.; Collette, F.; Sherif, S.; Talwar, P.; Zubkov, M.; Lamalle, L.; Vandewalle, G.
10.1101/2024.04.25.591085 — neuroscience — Posted on 2024-04-28
628 Yap is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates Expression of Ctgf in Cardiomyocytes.
Nelson, V. L.; Eadie, A. L.; Madhu, M.; Platt, M. J.; PULINILKUNNIL, T.; Kienesberger, P.; Simpson, J. A.; Brunt, K. R.
10.1101/2024.04.25.591002 — pharmacology and toxicology — Posted on 2024-04-28
629 ACTN3 genotype influences androgen response in skeletal muscle
Roeszler, K. N.; See, M.; Meehan, L. R.; Lima, G.; Kolliari-Turner, A.; Alexander, S. E.; Landen, S.; Wood, H. D.; Tiong, C. F.; Chen, W.; Mustafa, T.; Houweling, P. J.; Eynon, N.; Lamon, S.; Pitsiladis, Y.; Handelsman, D. J.; Rossello, F. J.; Ramialison, M.; North, K. N.; Seto, J. T.
10.1101/2024.04.25.591034 — genetics — Posted on 2024-04-28
630 Embodiment of an artificial limb in the mouse model
Hayatou, Z.; Wang, H.; Chaillet, A.; Shulz, D.; estebanez, l.
10.1101/2024.04.25.591084 — neuroscience — Posted on 2024-04-28
633 Redesigning the Drosophila histone gene cluster: An improved genetic platform for spatiotemporal manipulation of histone function
Crain, A. T.; Nevil, M.; Leatham-Jensen, M. P.; Reeves, K. B.; Matera, A. G.; McKay, D. J.; Duronio, R. J.
10.1101/2024.04.25.591202 — genetics — Posted on 2024-04-28
634 Light-induced Extracellular Vesicle Adsorption
Hisey, C. L.; Rima, X. Y.; Doon-Ralls, J.; Nagaraj, C. K.; Mayone, S.; Nguyen, K. T. K.; Wiggins, S.; Dorayappan, K.; Selvendiran, K.; Wood, D.; Hu, C.; Patel, D.; Palmer, A.; Hansford, D.; Reategui, E.
10.1101/2024.04.24.590318 — bioengineering — Posted on 2024-04-28
636 APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
Naguib, S. A.; Torres, E. R.; Lopez-Lee, C.; Fan, L.; Bhagwat, M.; Norman, K.; Lee, S.-I.; Zhu, J.; Ye, P.; Wong, M. Y.; Patel, T.; Mok, S.-A.; Luo, W.; Sinha, S.; Zhao, M.; Gong, S.; Gan, L.
10.1101/2024.04.25.591140 — neuroscience — Posted on 2024-04-28
637 Engineering Memory T Cells as a platform for Long-Term Enzyme Replacement Therapy in Lysosomal Storage Disorders
Kleinboehl, E.; Laoharawee, K.; Jensen, J. D.; Peterson, J. J.; Slipek, N. J.; Wick, B. J.; Johnson, M. J.; Webber, B. R.; Moriarity, B. S.
10.1101/2024.04.23.590790 — bioengineering — Posted on 2024-04-28
639 Measuring single-cell density with high throughput enables dynamic profiling of immune cell and drug response from patient samples
Wu, W.; Ishamuddin, S. H.; Quinn, T. W.; Yerrum, S.; Zhang, Y.; Debaize, L. L.; Kao, P.-L.; Duquette, S. M.; Murakami, M. A.; Mohseni, M.; Chow, K.-H.; Miettinen, T. P.; Ligon, K. L.; Manalis, S. R.
10.1101/2024.04.25.591092 — bioengineering — Posted on 2024-04-28
644 Effects of fire and fire-induced changes in soil properties on post-burn soil respiration
Johnson, D. B.; Yedinak, K. M.; Sulman, B. N.; Berry, T. D.; Kruger, K.; Whitman, T.
10.1101/2024.04.23.590763 — ecology — Posted on 2024-04-28
647 Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs
Chao, S.; Lu, J.; Li, L.-J.; Guo, H.-Y.; Xu, K.; Wang, N.; Zhao, S.-X.; Jin, X.-W.; Wang, S.-G.; Yin, S.; Shen, W.; Zhao, M.-H.; Huang, G.-A.; Sun, Q.-Y.; Ge, Z.-J.
10.1101/2024.04.24.590938 — developmental biology — Posted on 2024-04-28
648 Biodetection of an odor signature in white-tailed deer associated with infection by chronic wasting disease prions.
Golden, G. J.; Ramirez, E. A.; Stevens, H. N.; Bourbois, J.; Grove, D. M.; Bowen, R. A.; DeLiberto, T. J.; Kimball, B. A.
10.1101/2024.04.24.590903 — animal behavior and cognition — Posted on 2024-04-28
650 RAG suppresses group 2 innate lymphoid cells
Ver Heul, A.; Mack, M.; Zamidar, L.; Tamari, M.; Yang, T.-L.; Trier, A.; Kim, D.-H.; Janzen-Meza, H.; Van Dyken, S.; Hsieh, C.-S.; Karo, J. M.; Sun, J.; Kim, B. S.
10.1101/2024.04.23.590767 — immunology — Posted on 2024-04-28
655 The signaling axis CDK12-BRCA1 mediates dinaciclib associated radiosensitivity through p53-mediated cellular senescence.
Garcia-Flores, N.; Fernandez-Aroca, D. M.; Garnes Garcia, C.; Dominguez-Calvo, A.; sabater, s.; Andres, I.; Jimenez Suarez, J.; Fernandez-Aroca, P.; Cimas, F. J.; de Carcer, G.; Belandia, B.; Palmero, I.; Huertas, P.; Ruiz-Hidalgo, M. j.; Sanchez-Prieto, R.
10.1101/2024.04.25.590582 — cancer biology — Posted on 2024-04-28
656 Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats
Mardinoglu, A.; Yang, H.; Zhang, C.; Kim, W.; Shi, M.; Kiliclioglu, M.; Bayram, C.; Bolar, I.; Tozlu, O. O.; Baba, C.; Yuksel, N.; Yildirim, S.; Iqbal, S.; Sebhaoui, J.; Hacimuftuoglu, A.; Uhlen, M.; Boren, J.; Turkez, H.
10.1101/2024.04.22.590583 — bioinformatics — Posted on 2024-04-28
657 Dimer-monomer transition defines a novel hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome
Zhang, L.; Hu, F.; Zhao, Z.; Li, X.; Zhong, M.; He, J.; Yao, F.; Zhang, X.; Mao, Y.; Wei, H.; He, J.; Yang, H.
10.1101/2024.04.26.591248 — biochemistry — Posted on 2024-04-28
658 Copper acquisition is essential for plant colonization and virulence in a root-infecting vascular wilt fungus
Palos-Fernandez, R.; Aguilar Pontes, M. V.; Puebla-Planas, G.; Berger, H.; Studt-Reinhold, L.; Strauss, J.; Di Pietro, A.; Lopez-Berges, M. S.
10.1101/2024.04.23.590778 — genetics — Posted on 2024-04-28
661 RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during CNS viral infection
Estevez, I.; Buckley, B. D.; Panzera, N.; Lindman, M.; Chou, T.-W.; McCourt, M.; Vaglio, B. J.; Atkins, C.; Firestein, B. L.; Daniels, B. P.
10.1101/2024.04.26.591333 — neuroscience — Posted on 2024-04-28
665 Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo
Formichetti, S.; Sadowska, A.; Ascolani, M.; Hansen, J.; Ganter, K.; Lancrin, C.; Humphreys, N.; Boulard, M.
10.1101/2024.04.24.590926 — developmental biology — Posted on 2024-04-28
667 Disentangling signal and noise in neural responses through generative modeling
Kay, K.; Prince, J. S.; Gebhart, T.; Tuckute, G.; Zhou, J.; Naselaris, T.; Schutt, H.
10.1101/2024.04.22.590510 — neuroscience — Posted on 2024-04-27
668 An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
Nelson, E. D.; Tippani, M.; Ramnauth, A. D.; Divecha, H. R.; Miller, R. A.; Eagles, N. J.; Pattie, E. A.; Kwon, S. H.; Bach, S. V.; Kaipa, U. M.; Yao, J.; Kleinman, J. E.; Collado-Torres, L.; Han, S.; Maynard, K. R.; Hyde, T. M.; Martinowich, K.; Page, S. C.; Hicks, S. C.
10.1101/2024.04.26.590643 — neuroscience — Posted on 2024-04-28
670 Phylogenomic analysis of the Lake Kronotskoe species flock of Dolly Varden charr reveals genetic and developmental signatures of sympatric radiation
Woronowicz, K. C.; Esin, E. V.; Markevich, G. N.; Soto Martinez, C.; McMenamin, S.; Daane, J. M.; Harris, M. P.; Shkil, F. N.
10.1101/2023.02.24.529919 — evolutionary biology — Posted on 2024-04-27
673 Sperm derived H2AK119ub1 is required for embryonic development in Xenopus Laevis
Jullien, J.; Francois-Campion, V.; Berger, F.; Goumeidane, M.; Oikawa, M.; Gibeaux, R.
10.1101/2024.04.23.590676 — developmental biology — Posted on 2024-04-27
674 Generation of a zebrafish neurofibromatosis model via inducible knockout of nf2
Desingu Rajan, A. R.; Huang, Y.; Stundl, J.; Irodi, A.; Yang, Z.; Applegate, B. E.; Bronner, M.
10.1101/2024.04.23.590787 — developmental biology — Posted on 2024-04-27
676 Impacts of global warming on fertility of male fishes: evidence from meta-analysis of temperature effects on spermatozoa motility
Cheng, Y.; Wang, J.; Alavi, S. M. H.; Zhang, S.; Linhartov, Z.; Roy, D. R.; Shazada, N. E.; Dzyuba, B.; Linhart, O.
10.1101/2024.04.24.590878 — cell biology — Posted on 2024-04-28
677 Interplay between particle size and microbial ecology in the gut microbiome
Letourneau, J.; Carrion, V. M.; Jiang, S.; Osborne, O. W.; Holmes, Z. C.; Fox, A.; Epstein, P.; Tan, C. Y.; Kirtley, M.; Surana, N. K.; David, L. A.
10.1101/2024.04.26.591376 — microbiology — Posted on 2024-04-28
679 Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations
Mei, I.; Nichterwitz, S.; Leboeuf, M.; Nijssen, J.; Lenoel, I.; Repsilber, D.; Lobsiger, C. S.; Hedlund, E.
10.1101/2024.03.15.584775 — neuroscience — Posted on 2024-04-28
680 Gamma-burst cortical activity in awake behaving macaques
Acland, B. T.; Palanca, B. J. A.; Bijsterbosch, J. D.; Snyder, L. H.
10.1101/2023.09.26.559594 — neuroscience — Posted on 2024-04-28
681 Highly Dynamic and Sensitive NEMOer Calcium Indicators for Imaging ER Calcium Signals in Excitable Cells
Gu, W.; Chen, J.-H.; Zhang, Y.; Wang, Z.; Li, J.; Wang, S.; Zhang, H.; Jiang, A.; Zhong, Z.; Zhang, J.; Xi, C.; Hou, T.; Gill, D. L.; Li, D.; Mu, Y.; Wang, S.-Q.; Tang, A.-H.; Wang, Y.
10.1101/2024.03.08.583332 — synthetic biology — Posted on 2024-04-28
686 Deep learning-driven imaging of cell division and cell growth across an entire eukaryotic life cycle
Ramakanth, S.; Kennedy, T.; Yalcinkaya, B.; Neupane, S.; Tadic, N.; Buchler, N. E.; Arguello-Miranda, O.
10.1101/2024.04.25.591211 — cell biology — Posted on 2024-04-27
689 Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response
Lu, L.-F.; Zhang, C.; Li, Z.-C.; Cui, B.-J.; Wang, Y.-Y.; Han, K.-J.; Xu, X.; Zhou, C.-J.; Zhou, X.-Y.; Wu, Y.; Xu, N.; Yang, X.-L.; Chen, D.-D.; Li, X.; Zhou, L.; Li, S.
10.1101/2024.04.23.590743 — immunology — Posted on 2024-04-27
691 Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo
Formichetti, S.; Sadowska, A.; Ascolani, M.; Hansen, J.; Ganter, K.; Lancrin, C.; Humphreys, N.; Boulard, M.
10.1101/2024.04.24.590926 — developmental biology — Posted on 2024-04-27
692 Hair follicles modulate skin barrier function
Ford, N. C.; Benedeck, R. E.; Mattoon, M. T.; Peterson, J. K.; Mesler, A. L.; Veniaminova, N. A.; Gardon, D. J.; Tsai, S.-Y.; Uchida, Y.; Wong, S. Y.
10.1101/2024.04.23.590728 — developmental biology — Posted on 2024-04-27
693 High-resolution atlas of the developing human heart and the great vessels
Bayraktar, S.; Cranley, J.; Kanemaru, K.; Knight-Schrijver, V. R.; Colzani, M.; Davaapil, H.; Lee, J. C. M.; Polanski, K.; Richardson, L.; Semprich, C.; Kapuge, R.; Dabrowska, M.; Mulas, I.; Perera, S.; Patel, M.; Ho, Y.; He, X.; Tyser, R.; Gambardella, L.; Teichmann, S.; Sinha, S.
10.1101/2024.04.27.591127 — developmental biology — Posted on 2024-04-27
694 Substrate-directed control of N-glycosylation in the endoplasmic reticulum calibrates signal reception at the cell-surface
Rohatgi, R.; Ma, M.; Dubey, R.; Jen, A.; Pusapati, G. V.; Shishkova, E.; Overmyer, K. A.; Cormier-Daire, V.; Aravind, L.; Coon, J. J.
10.1101/2024.04.25.591210 — cell biology — Posted on 2024-04-27
695 Quantitative chromatin protein dynamics during replication origin firing in human cells
Gadi, S. A.; Hendriks, I. A.; Nielsen, C. F.; Popova, P.; Hickson, I. D.; Nielsen, M. L.; Toledo, L.
10.1101/2024.04.25.590934 — cell biology — Posted on 2024-04-27
696 Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae during bloodstream infection
Huang, Y.; Zhao, Z.; Li, K.; Huang, X.; Tian, X.; Meng, J.; Zhou, H.; Wu, J.; Dai, Q.; Zhang, J.-R.; An, H.
10.1101/2024.04.26.591417 — microbiology — Posted on 2024-04-27
698 Single-cell data reveal heterogeneity of resource allocation across a bacterial population
Pavlou, A.; Cinquemani, E.; Pinel, C.; Giordano, N.; Van Melle-Gateau, M.; Mihalcescu, I.; Geiselmann, J.; de Jong, H.
10.1101/2024.04.26.591328 — microbiology — Posted on 2024-04-27
699 Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection
Belmont, L.; Contreras, M.; Cartwright-Acar, C. H.; Marceau, C. D.; Agrawal, A.; Levoir, L. M.; Lubow, J.; Goo, L.
10.1101/2024.04.26.591029 — microbiology — Posted on 2024-04-27
701 Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons
Sleigh, J. N.; Mattedi, F.; Richter, S.; Annuario, E.; Ng, K.; Steinmark, I. E.; Ivanova, I.; Daraban, I. L.; Joshi, P. P.; Rhymes, E. R.; Awale, S.; Yahioglu, G.; Mitchell, J. C.; Suhling, K.; Schiavo, G.; Vagnoni, A.
10.1101/2023.09.18.558344 — neuroscience — Posted on 2024-04-27
702 Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training.
Viggars, M. R.; Berko, H. E.; Hesketh, S. J.; Wolff, C. A.; Gutierrez Monreal, M. A.; Martin, R. A.; Jennings, I. G.; Huo, Z.; Esser, K. A.
10.1101/2023.10.13.562100 — physiology — Posted on 2024-04-27
705 On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
Frey, L.; Ghosh, D.; Qureshi, B. M.; Rhyner, D.; Guerrero-Ferreira, R.; Pokharna, A.; Kwiatkowski, W.; Serdiuk, T.; Picotti, P.; Riek, R.; Greenwald, J.
10.1101/2023.06.25.546428 — biophysics — Posted on 2024-04-27
706 Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape
Vongsouthi, V.; Georgelin, R.; Matthews, D.; Saunders, J.; Lee, B. M.; Ton, J.; Damry, A. M.; Frkic, R.; Spence, M. A.; Jackson, C. J.
10.1101/2024.04.25.591214 — biochemistry — Posted on 2024-04-27
707 Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins
Xu, T.; Heon-Roberts, R.; Moore, T.; Dubot, P.; Pan, X.; Guo, T.; Cairo, C. W.; Holley, R.; Bigger, B.; Durcan, T.; Levade, T.; Ausseil, J.; Amilhon, B.; Gorelik, A.; Nagar, B.; Sturiale, L.; Palmigiano, A.; Roeckle, I.; Thiesler, H.; Hildebrandt, H.; Garozzo, D.; Pshezhetsky, A. V.
10.1101/2024.04.26.587986 — biochemistry — Posted on 2024-04-27
709 An inflection point in high-throughput proteomics with Orbitrap Astral: analysis of biofluids, cells, and tissues
Hendricks, N. G.; Bhosale, S. D.; Keoseyan, A. J.; Ortiz, J.; Stotland, A.; Seyedmohammad, S.; Nguyen, C. D. L.; Bui, J.; Moradian, A.; Mockus, S. M.; Van Eyk, J. E.
10.1101/2024.04.26.591396 — biochemistry — Posted on 2024-04-27
711 The interplay between light, arsenic and H2O2 controls oxygenic photosynthesis in a Precambrian analog cyanobacterial mat.
Castillejos Sepulveda, A.; Speth, D. R.; Kerl, C.; Doherty-Weason, D.; Vignale, F. A.; Santha, K.; Chennu, A.; Mohr, W.; Merz, E.; de Beer, D.; Farias, M. E.; Klatt, J.
10.1101/2024.04.27.591451 — biochemistry — Posted on 2024-04-27
713 Membrane permeability selection drove the stereochemistry of life
Goode, O.; Lapinska, U.; Glover, G.; Milner, D. S.; Santoro, A. E.; Pagliara, S.; Richards, T.
10.1101/2024.04.23.590732 — evolutionary biology — Posted on 2024-04-27
715 Neuron-derived Prox1 suppresses injury-induced reprogramming of Muller glia to proliferative retinal progenitor cells
Lee, E. J.; Kim, M.; Park, S.; Shim, J.-H.; Cho, H.-J.; Park, J. A.; Park, K.; Lee, D.; Kim, J. H.; Jeong, H.; Matsuzaki, F.; Kim, S.-Y.; Kim, J.; Yang, H.; Lee, J.-S.; Kim, J. W.
10.1101/2024.04.23.590652 — developmental biology — Posted on 2024-04-27
719 Spatial mapping of dextran sodium sulphate-induced intestinal inflammation and its systemic effects
Adams, L.; Rasid, O.; Hulme, H.; Quon, T.; Burchmore, R.; Milling, S.; Goodwin, R.; Wall, D. M.
10.1101/2024.04.26.591292 — molecular biology — Posted on 2024-04-27
720 Unraveling the Molecular Landscape of Uterine Fibroids, Insights into HMGA2 and Stem Cell Involvement
Paul, E. N.; Carpenter, T. J.; Pavliscak, L. A.; Bennett, A. Z.; Ochoa-Bernal, M. A.; Fazleabas, A. T.; Teixeira, J. M.
10.1101/2024.04.26.591351 — molecular biology — Posted on 2024-04-27
723 Jumping DNA polymerases in bacteriophages
Yutin, N.; Mutz, P.; Wolf, Y. I.; Krupovic, M.; Koonin, E. V.
10.1101/2024.04.26.591309 — microbiology — Posted on 2024-04-27
728 Transcriptional regulators ensuring specific gene expression and decision making at high TGFβ doses
Legewie, S.; Hartmann, L.; Kristofori, P.; Lenhardt, S.; Loewer, A.; Hexemer, L.; Becker, K.; Bohn, S.; Voss, B.; Weiss, S.; Li, C.
10.1101/2024.04.23.590740 — systems biology — Posted on 2024-04-27
734 Modification of Azithromycin to Mitigate its Arrest of Autophagy
Quarrington, R. D.; Sapula, S. A.; Lester, S. E.; Miller, M. M.; Munic Kos, V.; Kopp, B. T.; Jersmann, H. P.; Blencowe, A.; Roscioli, E.
10.1101/2024.04.25.591217 — biochemistry — Posted on 2024-04-27
738 Polarity-JaM: An image analysis toolbox for cell polarity, junction and morphology quantification
Giese, W.; Albrecht, J. P.; Oppenheim, O.; Akmeric, E. B.; Kraxner, J.; Schmidt, D.; Harrington, K. I.; Gerhardt, H.
10.1101/2024.01.24.577027 — bioinformatics — Posted on 2024-04-27
740 Engineering of highly active and diverse nuclease enzymes by combining machine learning and ultra-high-throughput screening
Thomas, N.; Belanger, D.; Xu, C.; Lee, H.; Hirano, K.; Iwai, K.; Polic, V.; Nyberg, K. D.; Hoff, K.; Frenz, L.; Emrich, C. A.; Kim, J. W.; Chavarha, M.; Ramanan, A.; Agresti, J. J.; Colwell, L. J.
10.1101/2024.03.21.585615 — bioinformatics — Posted on 2024-04-27
742 Assessment of the level of pollution based on soil and Tilia europaea leaves
Simon, E.; Ismail, H. B.; Sipos, B.; Abriha-Molnar, V. E.; Abriha, D.; Tozser, D.; Sajtos, Z.; Boluda, R.; Roca-Perez, L.
10.1101/2024.04.17.589890 — ecology — Posted on 2024-04-27
743 A Novel ARNT-Dependent HIF-2α Signaling as a Protective Mechanism for Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction
Ullah, K.; Ai, L.; Li, Y.; Liu, L.; Zhang, Q.; Pan, K.; Humayun, Z.; Piao, L.; Sitikov, A.; Su, Q.; Zhao, Q.; Sharp, W. W.; Fang, Y.; Wu, D.; Liao, J. K.; Wu, R.
10.1101/2023.03.12.532316 — cell biology — Posted on 2024-04-27
745 A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system
Aleman, J.; K, R.; Wiegand, C.; Schurdak, M. E.; Vernetti, L.; Gavlock, D.; Reese, C.; DeBiasio, R.; LaRocca, G.; Angarita, Y. D.; Gough, A.; Soto-Gutierrez, A.; Behari, J.; Miedel, M. T.; Stern, A. M.; Banerjee, I.; Taylor, D. L.
10.1101/2024.04.22.590598 — bioengineering — Posted on 2024-04-27
746 Association of diet and inflammation with the vaginal microbiota of pregnant individuals with or without IBD
Vargas Robles, D.; Yan Rou, Y.; Singha, B.; Tien, J.; Purandare, M.; Rojas-Correa, M.; Madziar, C.; Picker, M.; Dumont, T.; Leftwich, H.; Frisard, C. F.; Ward, D. V.; Peter, I.; Olendzki, B.; Maldonado-Contreras, A.
10.1101/2024.04.23.590846 — microbiology — Posted on 2024-04-27
747 Streptococcus pneumoniae infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases
Lee, N.; Bhalla, M.; Pereira, J. M.; Clark, S.; Roggensack, S. E.; Lovy, A.; Pereira, M. J.; Arroyo, G.; Adams, W.; Camilli, A.; Tweten, R. K.; Leong, J. M.; Sousa, S.; Bou Ghanem, E.
10.1101/2024.04.17.590015 — microbiology — Posted on 2024-04-27
749 NEURD: automated proofreading and feature extraction for connectomics
Celii, B.; Papadopoulos, S.; Ding, Z.; Fahey, P. G.; Wang, E.; Papadopoulos, C.; Kunin, A.; Patel, S.; Bae, J. A.; Bodor, A. L.; Brittain, D.; Buchanan, J.; Bumbarger, D. J.; Castro, M. A.; Cobos, E.; Dorkenwald, S.; Elabbady, L.; Halageri, A.; Jia, Z.; Jordan, C.; Kapner, D.; Kemnitz, N.; Kinn, S.; Lee, K.; Li, K.; Lu, R.; Macrina, T.; Mahalingam, G.; Mitchell, E.; Mondal, S. S.; Mu, S.; Nehoran, B.; Popovych, S.; Schneider-Mizell, C. M.; Silversmith, W.; Takeno, M.; Torres, R.; Turner, N. L.; Wong, W.; Wu, J.; Yu, S.-c.; Yin, W.; Xenes, D.; Kitchell, L. M.; Rivlin, P. K.; Rose, V. A.; Bishop
10.1101/2023.03.14.532674 — neuroscience — Posted on 2024-04-27
750 Lesion-induced impairment of therapeutic capacities of olfactory ensheathing cells in an autologous transplantation model for treatment of spinal cord injury
Delarue, Q.; Brodier, M.; Neveu, P.; Moncomble, L.; Hugede, A.; Blondin, A.; Robac, A.; Raimond, C.; Lecras, P.; Riou, G.; Guerout, N.
10.1101/2024.04.19.590121 — neuroscience — Posted on 2024-04-27
751 A proximity proteomics pipeline with improved reproducibility and throughput
Zhong, X.; Li, Q.; Polacco, B. J.; Patil, T.; Marley, A.; Foussard, H.; Khare, P.; Vartak, R.; Xu, J.; DiBerto, J. F.; Roth, B.; Eckhardt, M.; von Zastrow, M.; Krogan, N. J.; Huttenhain, R.
10.1101/2023.04.11.536358 — systems biology — Posted on 2024-04-27
752 β-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Young Mice
Franklin, M. K.; Sawada, H.; Howatt, D. A.; Amioka, N.; Liang, C.-L.; Zhang, N.; Graf, D. B.; Moorleghen, J. J.; Katsumata, Y.; Lu, H. S.; Daugherty, A.
10.1101/2023.10.22.563474 — pathology — Posted on 2024-04-27
754 ROMO1 and Mitochondrial Complex II/SDH are Required for Spare Respiratory Capacity and Glucose Homeostasis in Mice
Wells, L.; Yang, Q.; Iorio, C.; Peragerasingam, M.; Campbell, Z.; Ng, A. C.-H.; Reeks, C.; Yee, S.-P.; Screaton, R. A.
10.1101/2021.04.28.441811 — cell biology — Posted on 2024-04-27
756 Loss of TRIM21 drives UVB-induced systemic inflammation by regulating DNA-sensing pathways
Tumurkhuu, G.; Moore, R.; Perri, G.; Huo, L.; Naveen Kumar, A.; De Los Santos, G.; Gibb, D.; Carriere, J.; Yu, Y. M.; Abuav, R.; Wallace, D.; Ishimori, M.; Shon, W.; Dortfleutner, A.; Stehlik, C.; Jefferies, C.
10.1101/2024.04.10.588897 — immunology — Posted on 2024-04-27
758 The attenuation of activity-based anorexia by obese adipose tissue transplant is AgRP neuron-dependent.
Yoon, D. J.; Zhang, J.; Zapata, R.; Ulivieri, M.; Libster, A. M.; McMurray, M. S.; Osborn, O.; Dulawa, S. C.
10.1101/2024.04.23.590824 — neuroscience — Posted on 2024-04-27
760 Chloroquine attenuates hypoxia-mediated autophagy to curb thrombosis- an ex vivo and in vivo study
Bandyopadhyay, P.; Katakia, Y. T.; Mukherjee, S.; Majumder, S.; Chowdhury, S.; Chowdhury, R.
10.1101/2024.04.23.590850 — physiology — Posted on 2024-04-27
761 Sound-mediated nucleation and growth of amyloid fibrils
Kozell, A.; Solomonov, A.; Gaidarov, R.; Benyamin, D.; Greenblatt, H. M.; Levy, Y.; Rosenhek-Goldian, I.; Amir, A.; Raviv, U.; Shimanovich, U.
10.1101/2023.09.16.558053 — biochemistry — Posted on 2024-04-27
763 Repeated loss of function at HD mating-type genes and of recombination suppression without mating-type locus linkage in anther-smut fungi
Lucotte, E. A.; Jay, P.; Rougemont, Q.; Boyer, L.; Cornille, A. A.; Snirc, A.; Labat, A.; Chahine, E.; Duhamel, M.; Gendelman, J.; Ma, W.-J.; Hayes, R. K.; Perlin, M. H.; Hood, M.; Rodriguez de la Vega, R. C.; Giraud, T.
10.1101/2024.03.03.583181 — evolutionary biology — Posted on 2024-04-27
764 Quantifying competition between two demersal fish species from spatiotemporal stomach content data
Lindmark, M.; Maioli, F.; Anderson, S. C.; Gogina, M.; Bartolino, V.; Skold, M.; Ohlsson, M.; Eklof, A.; Casini, M.
10.1101/2024.04.22.590538 — ecology — Posted on 2024-04-27
766 Metaproteogenomics resolution of a high-CO2 aquifer community suggests an active symbiotic lifestyle of groundwater Gracilibacteria
Figueroa-Gonzalez, P. A.; Bornemann, T. L. V.; Hinzke, T.; Maass, S.; Trautwein-Schult, A.; Starke, J.; Moore, C. J.; Esser, S. P.; Plewka, J.; Hesse, T.; Schmidt, T. C.; Schreiber, U.; Bor, B.; Becher, D.; Probst, A. J.
10.1101/2023.12.18.572140 — ecology — Posted on 2024-04-27
767 Efficient modelling of infectious diseases in wildlife: a case study of bovine tuberculosis in wild badgers
Konzen, E.; Delahay, R. J.; Hodgson, D. J.; McDonald, R. A.; Brooks Pollock, E.; Spencer, S. E. F.; McKinley, T. J.
10.1101/2024.01.26.576600 — ecology — Posted on 2024-04-27
768 Pharmaco-resistant temporal lobe epilepsy gradually perturbs the cortex-wide excitation-inhibition balance
Xie, K.; Royer, J.; Rodriguez-Cruces, R.; Horwood, L.; Ngo, A.; Arafat, T.; Auer, H.; Sahlas, E.; Chen, J.; Zhou, Y.; Valk, S. L.; Hong, S.-J.; Frauscher, B.; Pana, R.; Bernasconi, A.; Bernasconi, N.; Concha, L.; Bernhardt, B. C.
10.1101/2024.04.22.590555 — neuroscience — Posted on 2024-04-27
770 Noise Stress induces Cardiovascular Metabolic Shifts
Marques, J. G.; Kuntic, M.; Krishnankutty, R.; Blanco, G. R.; Malkov, M.; Frenis, K.; Wills, J.; Shokry, E.; Chee, F. L.; Taylor, C. T.; Munzel, T.; Daiber, A.; von Kriegsheim, A.
10.1101/2024.04.22.590539 — systems biology — Posted on 2024-04-27
773 Targeting the sphingolipid rheostat in IDH1mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation
Larion, M.; Dowdy, T.; Muley Vilamu, H.; Lita, A.; Li, A.; Yamasaki, T.; Zhang, L.; Chari, R.; Song, H.; Zhang, M.; Zhang, W.; Briceno, N.; Davis, D.; Gilbert, M. R.
10.1101/2024.04.26.591321 — cancer biology — Posted on 2024-04-27
775 The nuclear speckles protein SRRM2 is a new therapeutic target molecule on the surface of cancer cells
Kellner, M.; Hoermann, J.; Fackler, S.; Yuanyu, H.; Lin, L.; Ilik, I.; Aktas, T.; Feederle, R.; Hauck, S. M.; Gires, O.; Gaertner, K.; Lietao, L.; Zeidler, R.
10.1101/2024.04.26.591288 — cancer biology — Posted on 2024-04-27
778 Mild Hyperthermia Enhanced Liposomal Doxorubicin Delivery and CD8+ T cell Infiltration in Triple Negative Breast Cancer
Viola, N.; Saadat, W.; Smith, R.; Pattyn, A.; Malik, M.; Yazdani, F.; Saliganan, A.-D.; Mehrmohammadi, M.
10.1101/2024.04.25.591226 — cancer biology — Posted on 2024-04-27
781 Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer
Visser, E.; Donaldson Collier, M.; Siefert, J.; Konstantinidou, M.; Paul, S.; Berkhout, J.; Virta, J.; Somsen, B.; Cossar, P.; Miley, G.; Luzietti, L.; Young, L.; Vareslija, D.; Buluwela, L.; Ali, S.; Meijer, O.; Arkin, M. R.; Ottmann, C. O. R.; Zwart, W.; Brunsveld, L.
10.1101/2024.04.25.591105 — cancer biology — Posted on 2024-04-27
782 Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor Microenvironments
Hosohama, L.; Tifrea, D. F.; Nee, K.; Park, S. Y.; Wu, J.; Habowski, A. N.; Van, C.; Seldin, M. M.; Edwards, R. A.; Waterman, M. L.
10.1101/2024.04.25.591144 — cancer biology — Posted on 2024-04-27
783 CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer
Zhong, C.; Jiang, W.-J.; Yao, Y.; Li, Z.; Li, Y.; Wang, S.; Wang, X.; Zhu, W.; Wu, S.; Wang, J.; Fan, S.; Ma, S.; Liu, Y.; Zhang, H.; Zhao, W.; Zhao, L.; Feng, Y.; Li, Z.; Guo, R.; Yu, L.; Pei, F.; Hu, J.; Feng, X.; Yang, Z.; Yang, Z.; Yang, X.; Hou, Y.; Zhang, D.; Xu, D.; Sheng, R.; Li, Y.; Liu, L.; Wu, H.-J.; Huang, J.; Fei, T.
10.1101/2024.04.24.591030 — cancer biology — Posted on 2024-04-27
784 Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma
Floros, K. V.; Fairchild, C. K.; Li, J.; Zhang, K.; Roberts, J. L.; Kurupi, R.; Hu, B.; Kraskauskiene, V.; Hosseini, N.; Shen, S.; Inge, M. M.; Smith-Fry, K.; Li, L.; Sotiriou, A.; Dalton, K. M.; Jose, A.; Abdelfadiel, E. I.; Xing, Y.; Hill, R. D.; Slaughter, J. M.; Shende, M.; Lorenz, M. R.; Hinojosa, M. R.; Belvin, B. R.; Lai, Z.; Books, S. A.; Stamatouli, A. M.; Lewis, J. P.; Manjil, M. H.; Valerie, K.; Li, R.; Banito, A.; Poklepovic, A.; Koblinski, J.; Siggers, T.; Dozmorov, M. G.; Jones, K. B.; Radhakrishnan, S. K.; Faber, A. C.
10.1101/2024.04.25.591023 — cancer biology — Posted on 2024-04-27
786 Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma
Licon-Munoz, Y.; Avalos, V.; Subramanian, S.; Granger, B.; Martinez, F.; Varela, S.; Moore, D.; Perkins, E.; Kogan, M.; Berto, S.; Chohan, M. O.; Bowers, C. A.; Piccirillo, S. G. M.
10.1101/2024.04.24.590852 — cancer biology — Posted on 2024-04-27
787 Disrupting USP39 deubiquitinase Function Impairs the Survival and Migration of Multiple Myeloma Cells through ZEB1 Degradation
Sirera, J.; Sarlak, S.; Teisseire, M.; Carminati, A.; Nicolini, V.; Brest, P.; Bontoux, C.; Deckert, M.; Ohanna, M.; GIULIANO, S.; Dufies, M.; Pages, G.; Luciano, F.
10.1101/2024.04.23.590548 — cancer biology — Posted on 2024-04-27
790 CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC
Yuan, X.; Hao, X.; Chan, H. L.; Zhao, N.; Pedroza, D. A.; Liu, F.; Le, K.; Smith, A. J.; Calderon, S. J.; Lieu, N.; Soth, M. J.; Jones, P.; Zhang, X. H.- F.; Rosen, J. M.
10.1101/2024.04.25.590983 — cancer biology — Posted on 2024-04-27
793 Unified somatic calling and machine learning-based classification enhance the discovery of clonal hematopoiesis of indeterminate potential
Tian, S.; Ferrer, A.; Yan, H.; Morales-Rosado, J.; Lasho, T. L.; Wang, K.; Baheti, S.; Olson, J. E.; Baughn, L. B.; Slager, S. L.; Patnaik, M. M.; Lazaridis, K. N.; Klee, E. W.
10.1101/2024.04.22.590586 — bioinformatics — Posted on 2024-04-27
796 Neural activity for complex sounds in the marmoset medial prefrontal cortex
Gilliland, R. E.; Selvanayagam, J.; Zanini, A.; Johnston, K.; Everling, S.
10.1101/2024.04.22.590560 — neuroscience — Posted on 2024-04-27
798 A detailed spatio-temporal atlas of the white matter tracts for the fetal brain
Calixto Nunez, C.; Soldatelli, M.; Jaimes Cobos, C.; Warfield, S. K.; Gholipour, A.; Karimi, D.
10.1101/2024.04.26.590815 — neuroscience — Posted on 2024-04-27
800 An image processing pipeline for electron cryo-tomography in RELION-5
Burt, A.; Toader, B.; Warshamanage, R.; von Kugelgen, A.; Pyle, E.; Zivanov, J.; Kimanius, D.; Bharat, T. A. M.; Scheres, S.
10.1101/2024.04.26.591129 — biophysics — Posted on 2024-04-27
807 A multi-organ map of the human immune system across age, sex and ethnicity
Mangiola, S.; Milton, M.; Ranathunga, N.; LiWaiSuen, C.; Yang, E.; Hutchison, W.; Garnham, A.; Iskander, J.; Pal, B.; Yadav, V. J.; Carey, V.; Kallies, A.; Bedoui, S.; Morgan, M.; Papenfuss, A. T.; Odainic, A.; Rossello, F.
10.1101/2023.06.08.542671 — immunology — Posted on 2024-04-26
808 Fitness landscape of substrate-adaptive mutations in evolved APC transporters
Karapanagioti, F.; Atlason, U. A.; Slotboom, D. J.; Poolman, B.; Obermaier, S.
10.1101/2023.10.12.562049 — biochemistry — Posted on 2024-04-26
810 Characterisation of RNA editing and gene therapy with a compact CRISPR-Cas13 in the retina
Kumar, S.; Hsiao, Y.-W.; Wong, V. H. Y.; Aubin, D.; Wang, J.-H.; Lisowski, L.; Rakoczy, E. P.; Li, F.; Alarcon-Martinez, L.; Gonzalez Cordero, A.; Bui, B. V.; Liu, G.-S.
10.1101/2024.02.10.579778 — molecular biology — Posted on 2024-04-26
812 A high-resolution map of functional miR-181 response elements in the thymus reveals the role of coding sequence targeting and an alternative seed match
Verheyden, N. A.; Klostermann, M.; Bruggemann, M.; Steede, H. M.; Scholz, A.; Amr, S.; Lichtenthaeler, C.; Munch, C.; Schmid, T.; Zarnack, K.; Krueger, A.
10.1101/2023.09.08.556730 — immunology — Posted on 2024-04-26
813 Hippocampal sharp wave ripples and coincident cortical ripples orchestrate human semantic networks
Mishra, A.; Akkol, S.; Espinal, E.; Markowitz, N.; Tostaeva, G.; Freund, E.; Mehta, A.; Bickel, S.
10.1101/2024.04.10.588795 — neuroscience — Posted on 2024-04-26
815 Radiation of pain: Psychophysical evidence for a population coding mechanism
Adamczyk, W. M.; Ramu, V.; Jackson, C.; Schulze, G.; Goldschneider, K.; Kashikar-Zuck, S.; King, C.; Coghill, R. C.
10.1101/2024.04.02.587666 — neuroscience — Posted on 2024-04-26
819 Exploring differences between depression and bipolar disorder through the urinary proteome
Liu, Y.; Li, Z.; Dong, Y.; Yang, J.; Li, M.; Zhou, J.; Gao, Y.; Li, J.; Wang, G.; Gao, Y.
10.1101/2024.04.24.590930 — biochemistry — Posted on 2024-04-26
820 A Cell-Permeable Nanobody to Restore F508del Cystic Fibrosis Transmembrane Conductance Regulator Activity
Franz, L.; Rubil, T.; Balazs, A.; Overtus, M.; Kemnitz-Hassanin, K.; Govaerts, C.; Mall, M. A.; Hackenberger, C. P.
10.1101/2024.04.26.591242 — biochemistry — Posted on 2024-04-26
823 Phenotype projections accelerate biobank-scale GWAS
Zietz, M.; Gisladottir, U.; Brown, K. L.; Tatonetti, N. P.
10.1101/2023.11.20.567948 — genetics — Posted on 2024-04-26
824 The Statistical Building Blocks of Animal Movement Simulations
Getz, W. M.; Salter, R.; Sethi, V.; Cain, S.; Spiegel, O.; Toledo, S.
10.1101/2023.12.27.573450 — ecology — Posted on 2024-04-26
825 Stm1 regulates Ifh1 activity revealing crosstalk between ribosome biogenesis and ribosome dormancy
Bianco, E.; Bonassera, M.; Uliana, F.; Tilma, J.; Winkler, M.; Zencir, S.; Albert, B.; Oborska-Oplova, M.; Dechant, R.; Hugener, J.; Panse, V. G.; Pilhofer, M.; Kimmig, P.; Peter, M.
10.1101/2024.04.22.590536 — cell biology — Posted on 2024-04-26
826 Rescue of lysosomal acid lipase deficiency in mice by rAAV8 liver gene transfer.
Laurent, M.; Harb, R.; Jenny, C.; Oustelandt, J.; Jimenez, S.; Cosette, J.; Landini, F.; Ferrante, A.; Corre, G.; Vujic, N.; Piccoli, C.; Brassier, A.; Van Wittenberghe, L.; Ronzitti, G.; Kratky, D.; Pacelli, C.; Amendola, M.
10.1101/2024.04.26.591270 — molecular biology — Posted on 2024-04-26
827 Ubiquitin-specific protease 8 controls B cell proteostasis and cell survival in multiple myeloma
Dufner, A.; Thery, F.; Monaco, G.; Lazarevic, J. L.; Gorka, O.; Chevalier, N.; Frosch, M.; van der Heden van Noort, G. J.; Prinz, M.; Gross, O.; Geurink, P. P.; Schamel, W. W.; Heissmeyer, V.; Denzel, M. S.; Bruns, H.; Schemionek, M.; Impens, F.; Knobeloch, K.-P.
10.1101/2024.04.26.591134 — molecular biology — Posted on 2024-04-26
834 CRISPR-GPT: An LLM Agent for Automated Design of Gene-Editing Experiments
Qu, Y.; Huang, K.; Cousins, H.; Johnson, W. A.; Yin, D.; Shah, M. M.; Zhou, D.; Altman, R. B.; Wang, M.; Cong, L.
10.1101/2024.04.25.591003 — bioinformatics — Posted on 2024-04-26
837 Ferroptosis Inhibition Combats Metabolic Derangements and Improves Cardiac Function in Pulmonary Artery Banded Pigs
Prins, K.; Moon, R.; Vogel, N.; Tollison, W.; Lahti, M.; Carney, J.; Mendelson, J. B.; Bianco, R.; Kazmirczak, F.
10.1101/2024.04.24.590907 — biochemistry — Posted on 2024-04-26
839 Ultra-deep proteomics by Thin-diaPASEF with a 60-cm long column system
Konno, R.; Ishikawa, M.; Nakajima, D.; Hagiwara, S.; Inukai, K.; Ohara, O.; Kawashima, Y.
10.1101/2024.04.26.591246 — biochemistry — Posted on 2024-04-26
840 Modification of Azithromycin to Mitigate its Arrest of Autophagy
Quarrington, R. D.; Sapula, S. A.; Lester, S. E.; Matthew, M. M.; Kos, V. M.; Kopp, B. T.; Jersmann, H. P.; Blencowe, A.; Roscioli, E.
10.1101/2024.04.25.591217 — biochemistry — Posted on 2024-04-26
841 Long range segmentation of prokaryotic genomes by gene age and functionality
Wolf, Y. I.; Schurov, I. V.; Makarova, K. S.; Katsnelson, M.; Koonin, E. V.
10.1101/2024.04.26.591304 — genomics — Posted on 2024-04-26
843 Increased host diversity limits bacterial generalism but may promote microbe-microbe interactions
Holmes, I. A.; Martinez-Fonseca, J. G.; von May, R.; Sealey, B. A.; Cerda, P.; Grundler, M. R.; Westeen, E. P.; Nondorf, D.; Larson, J. G.; Myers, C. R.; Hendry, T. A.
10.1101/2024.04.24.590977 — ecology — Posted on 2024-04-26
844 CRISPR PERSIST-On enables heritable and fine-tunable human gene activation
Tak, Y. E.; Hsu, J. Y.; Shih, J.; Schultz, H. T.; Nguyen, I. T.; Lam, K. C.; Pinello, L.; Joung, J. K.
10.1101/2024.04.26.590475 — molecular biology — Posted on 2024-04-26
847 Serotype switching in Pseudomonas aeruginosa ST111 enhances adhesion and virulence
Anbo, M.; Lubna, M. A.; Moustafa, D. A.; Paiva, T. O.; Serioli, L.; Zor, K.; Sternberg, C.; Jeannot, K.; Dufrene, Y. F.; Goldberg, J. B.; Jelsbak, L.
10.1101/2024.04.26.591252 — microbiology — Posted on 2024-04-26
849 Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks
Guo, R.; Chang, Y.; Wang, D.; Sun, H.; Zhao, A.; GU, T.; Zong, Y.; Zhou, S.; Huang, Z.; Chen, L.; Tian, Y.; XU, W.; Lu, L.; Zeng, T.
10.1101/2024.04.25.591173 — microbiology — Posted on 2024-04-26
850 PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses
Parthasarathy, S.; Saenjamsai, P.; Hao, H.; Ferkul, A.; Pfannenstiel, J. J.; Suder, E. L.; Bejan, D. S.; Chen, Y.; Schwarting, N.; Aikawa, M.; Muhlberger, E.; Orozco, R. C.; Sullivan, C. S.; Cohen, M. S.; Davido, D.; Hume, A. J.; Fehr, A.
10.1101/2024.04.26.591186 — microbiology — Posted on 2024-04-26
851 The T3SS structural and effector genes of Chlamydia trachomatis are expressed in distinct phenotypic cell forms.
Grieshaber, N.; Appa, C. R.; Ward, M.; Grossman, A.; McCormik, S.; Grieshaber, B. S.; Chiarelli, T. J.; Yang, H.; Omsland, A.; Grieshaber, S. S.
10.1101/2024.04.25.591156 — microbiology — Posted on 2024-04-26
852 Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection
Jiang, B.; Ren, P.; He, C.; Wang, M.; Murtada, S.-I.; Chen, Y.; Ramachandra, A. B.; Li, G.; Qin, L.; Assi, R.; Schwartz, M. A.; Humphrey, J. D.; Tellides, G.
10.1101/2024.04.22.590484 — pathology — Posted on 2024-04-26
854 Benchmarking tools for transcription factor prioritization
Schubert Santana, L.; Reyes, A.; Hoersch, S.; Ferrero, E.; Kolter, C.; Gaulis, S.; Steinhauser, S.
10.1101/2024.04.23.590206 — bioinformatics — Posted on 2024-04-26
856 Optimizing Exome Captures in Species with Large Genomes Using Species-specific Repetitive DNA Blocker
Kesalahti, R.; Kumpula, T. A.; Cervantes, S.; Kujala, S. T.; Mattila, T. M.; Tyrmi, J. S.; Niskanen, A. K.; Rastas, P.; Savolainen, O.; Pyhajarvi, T.
10.1101/2024.04.23.590505 — genomics — Posted on 2024-04-26
863 Three dimensionally printed microstructured alginate scaffolds for neural tissue engineering
Li, J.; Hietel, B.; Brunk, M. G. K.; Reimers, A.; Willems, C.; Groth, T.; Cynis, H.; Adelung, R.; Schutt, F.; Sacher, W. D.; Poon, J. K. S.
10.1101/2024.04.23.590678 — bioengineering — Posted on 2024-04-26
864 Sample multiplexing for retinal single-cell RNA-sequencing
Ma, J.; Chu, T. K.; Polo Prieto, M.; Park, Y.; Li, Y.; Chen, R.; Mardon, G.; Frankfort, B. J.; Tran, N. M.
10.1101/2024.04.23.589797 — genomics — Posted on 2024-04-26
865 Sampling Techniques and Genomic Analysis of Biological Material from Artworks
Roby, R. K.; Wiscovitch-Russo, R. A.; Hart, R.; Appel, A. E.; Kazmi, M. A.; Huber, T.; Aberg, K. C.; Sakmar, T. P.; Lorente, J. A.; Gonzalez-Juarbe, N.
10.1101/2024.04.23.589986 — genetics — Posted on 2024-04-26
867 Evolutionary history of the main extracellular matrix polysaccharides in brown algae
Mazeas, L.; Bouguerba-Collin, A.; Cock, J. M.; Denoeud, F.; Godfroy, O.; Brillet-Gueguen, L.; Barbeyron, T.; Lipinska, A. P.; Delage, L.; Corre, E.; Drula, E.; Henrissat, B.; Czjzek, M.; Terrapon, N.; Herve, C.
10.1101/2024.04.23.590721 — evolutionary biology — Posted on 2024-04-26
869 MIPDB: A maize image-phenotype database with multi-angle and multi-time characteristics
Wang, P.; Chang, J.; Deng, W.; Liu, B.; Lai, H.; Hou, Z.; Dong, L.; Chen, Q.; Zhou, Y.; Zhang, Z.; Liu, H.; Ruan, J.
10.1101/2024.04.26.589844 — plant biology — Posted on 2024-04-26
871 Daily glycome and transcriptome profiling reveals polysaccharide structures and glycosyltransferases critical for cotton fiber growth
Swaminathan, S.; Grover, C. E.; Mugisha, A. S.; Sichterman, L. E.; Lee, Y.; Yang, P.; Mallery, E. L.; Jareczek, J. J.; Leach, A. G.; Xie, J.; Wendel, J. F.; Szymanski, D. B.; Zabotina, O. A.
10.1101/2024.04.23.589927 — plant biology — Posted on 2024-04-26
872 QM/MM Free Energy Calculations of Long-Range Biological Protonation Dynamics by Adaptive and Focused Sampling
Poeverlein, M. C.; Hulm, A.; Dietschreit, J. C. B.; Kussmann, J.; Ochsenfeld, C.; Kaila, V. R. I.
10.1101/2024.04.23.589781 — biophysics — Posted on 2024-04-26
875 Phylogeography of bar-tailed godwits: pre-LGM structure in Beringia and westward colonization of post-glacial Europe
Conklin, J. R.; Verkuil, Y. I.; Lefebvre, M. J. M.; Battley, P. F.; Bom, R. A.; Gill, R. E.; Hassell, C. J.; ten Horn, J.; Ruthrauff, D. R.; Tibbitts, T. L.; Tomkovich, P. S.; Warnock, N.; Piersma, T.; Fontaine, M. C.
10.1101/2024.04.22.590527 — evolutionary biology — Posted on 2024-04-26
876 Sociality in spiders is an evolutionary dead-end
Ma, J.; Bechsgaard, J.; Aagaard, A.; Villesen, P.; Bilde, T.; Schierup, M.
10.1101/2024.04.22.590577 — evolutionary biology — Posted on 2024-04-26
878 Peste des Petits Ruminants virus virulence is associated with an early inflammatory profile in the tonsils and cell cycle arrest in lymphoid tissue
Eloiflin, R.-J.; Grau-Roma, L.; Lasserre, V.; Python, S.; Talker, S.; Totte, P.; Garcia- Nicolas, O.; Summerfield, A.; Bataille, A.
10.1101/2024.04.23.590699 — immunology — Posted on 2024-04-26
880 Neural networks representing temporal expectation in mice
Wendlandt, A. T.; Wenk, P.; Henschke, J. U.; Michalek, A.; Noesselt, T.; Pakan, J. M.; Budinger, E.
10.1101/2024.04.25.589683 — neuroscience — Posted on 2024-04-26
881 A dynamic compositional equilibrium governs mRNA recognition by eIF3
Ide, N. A.; Gentry, R. C.; Rudbach, M. A.; Yoo, K.; Velez, P. K.; Communale, V. M.; Hartwick, E. W.; Kinz-Thompson, C. D.; Gonzalez, R. L.; Aitken, C. E.
10.1101/2024.04.25.581977 — biophysics — Posted on 2024-04-26
882 De novo design of high-affinity single-domain antibodies
Van Der Kant, R.; Zhang, Z.; Markovic, I.; Vizarraga, D.; Garcia, T.; Maragkou, K.; Delgado Blanco, J.; Cianferoni, D.; Orlando, G.; Carolis, C.; Volkov, A. N.; Savvides, S. N.; DeWilde, M.; Schymkowitz, J.; Serrano Pubul, L.; Rousseau, F.
10.1101/2024.04.22.589762 — bioinformatics — Posted on 2024-04-26
887 Virological characteristics of the SARS-CoV-2 KP.2 variant
Kaku, Y.; Uriu, K.; Kosugi, Y.; Okumura, K.; Yamasoba, D.; Uwamino, Y.; Kuramochi, J.; Sadamasu, K.; Yoshimura, K.; Nagashima, M.; Asakura, H.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Ito, J.; Sato, K.
10.1101/2024.04.24.590786 — microbiology — Posted on 2024-04-26
888 T-cell acute lymphoblastic leukemia progression is supported by inflammatory molecules including Hepatocyte Growth factor
Le Maout, C.; Fahy, L.; Renou, L.; Devanand, C.; Duwat, C.; Barroca, V.; Le Gall, M.; Ballerini, P.; Petit, A.; Calvo, J.; Uzan, B.; Pflumio, F.; Petit, V.
10.1101/2024.04.24.590927 — cancer biology — Posted on 2024-04-26
891 Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma
Vinca, E.; Ehlers, A. C.; Ritter, A.; Obermeier, D.; Funk, C. M.; Geyer, F. H.; Schmucker, M.; Li, J.; Zimmermann, M.; Ceranski, A. K.; Fuchslocher, F.; Mertens, C.; Qiu, R.; Muckenthaler, M. M.; Dahlhaus, A.; von Karstedt, S.; Imle, R.; Banito, A.; Alonso, J.; Peterziel, H.; Witt, O.; Oehme, I.; Cidre-Aranaz, F.; Gruenewald, T. G. P.; Ohmura, S.
10.1101/2024.04.24.590877 — cancer biology — Posted on 2024-04-26
893 A maternal-effect toxin-antidote element causes larval arrest in C. elegans
Zdraljevic, S.; Walter-McNeill, L.; Bruni, G.; Marquez, H.; Leighton, D. H. W.; Bloom, J. S.; Kruglyak, L.
10.1101/2024.04.26.591160 — evolutionary biology — Posted on 2024-04-26
897 Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder
Dautan, D.; Paslawski, W.; Montejo, S.; Doyon, D.; Marangiu, R.; Kaplitt, M. G.; Chen, R.; Dawson, V. L.; Zhang, X.; Dawson, T. M.; Svenningsson, P.
10.1101/2024.04.22.590542 — neuroscience — Posted on 2024-04-26
898 Neuroanatomical dissection of the MC3R circuitry regulating energy rheostasis
Possa-Paranhos, I. C.; Butts, J.; Pyszka, E.; Nelson, C.; Cho, D.; Sweeney, P.
10.1101/2024.04.22.590573 — neuroscience — Posted on 2024-04-26
902 Inbreeding and gallbladder cancer risk: Homozygosity associations adjusted for indigenous American ancestry, BMI and genetic risk of gallstone disease
Ceballos, F.; Boekstegers, F.; Scherer, D.; Barahona Ponce, C.; Marcelain, K.; Garate-Calderon, V.; Rojas, A.; Munoz, C.; Retamales, J.; de Toro, G.; Vera Kortmann, A.; Barajas, O.; Rivera, M. T.; Cortes, A.; Loader, D.; Saavedra, J.; Gutierrez, L.; Ortega, A.; Bertran, M. E.; Bartolotti, L.; Gabler, F.; Campos, M.; Alvarado, J.; Moisan, F.; Spencer, L.; Nervi, B.; Carvajal-Hausdorf, D.; Losada, H.; Almau, M.; Fernandez, P.; Olloquequi, J.; Rothhammer, F.; Lorenzo Bermejo, J.
10.1101/2024.04.22.590517 — genetics — Posted on 2024-04-26
906 Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy
Xia, M.; Varmazyad, M.; Palacin, I. P.; Gavlock, D. C.; Debiasio, R.; LaRocca, G.; Reese, C.; Florentino, R.; Faccioli, L. A. P.; Brown, J. A.; Vernetti, L. A.; Schurdak, M. E.; Stern, A. M.; Gough, A.; Behari, J.; Soto-Gutierrez, A.; Taylor, D. L.; Miedel, M.
10.1101/2024.04.22.590608 — cell biology — Posted on 2024-04-26
907 Predicting Organoid Morphology Through a Phase Field Model: Insights into Cell Division and Lumenal Pressure
Tanida, S.; Fuji, K.; Lu, L.; Guyomar, T.; Lee, B. H.; Honigmann, A.; Grapin-Botton, A.; Riveline, D.; Hiraiwa, T.; Nonomura, M.; Sano, M.
10.1101/2024.04.22.590518 — cell biology — Posted on 2024-04-26
908 Multiple ubiquitin ligases protect human genome integrity by targeting cancer-associated APOBEC3 deaminases for degradation.
Schwartz, I.; Budroni, V.; Meyenberg, M.; Hornegger, H.; Hacker, K.; Schwartz, S.; Hodakova, Z.; Grabarczyk, D. B.; Ehrmann, J.; Scinicariello, S.; Haselbach, D.; Menche, J.; Clausen, T.; Karagoez, E.; Versteeg, G. A.
10.1101/2024.04.23.590688 — cell biology — Posted on 2024-04-26
909 Lipoxin A4/FPR2 signaling mitigates ferroptosis of alveolar epithelial cells via NRF2-dependent pathway during lung ischemia-reperfusion injury
Manual, D.; Leroy, V.; Tu, Z.; Woolet-Stockton, M.; Kamat, M.; Garrett, T.; Atkinson, C.; Cai, G.; Upchurch, G. R.; Sharma, A. K.
10.1101/2024.04.22.590127 — immunology — Posted on 2024-04-26
912 Large- Scale Deep Proteomic Analysis in Alzheimer's Disease Brain Regions Across Race and Ethnicity
Seifar, F.; Fox, E. J.; Shantaraman, A.; Liu, Y.; Dammer, E. B.; Modeste, E.; Duong, D. M.; Yin, L.; Trautwig, A. N.; Guo, Q.; Xu, K.; Ping, L.; Reddy, J. S.; Allen, M.; Quicksall, Z.; Heath, L.; Scanlan, J.; Wang, E.; Wang, M.; Vander Linden, A.; Poehlman, W.; Chen, X.; Baheti, S.; Ho, C.; Nguyen, T.; Yepez, G.; Mitchell, A. O.; Oatman, S. R.; Wang, X.; Carrasquillo, M. M.; Runnels, A.; Beach, T.; Serrano, G. E.; Dickson, D. W.; Lee, E. B.; Golde, T. E.; Prokop, S.; Barnes, L. L.; Zhang, B.; Haroutunian, V.; Gearing, M.; Lah, J. J.; De Jager, P.; Bennett, D. A.; Greenwood, A.; Ertekin-Taner,
10.1101/2024.04.22.590547 — neuroscience — Posted on 2024-04-26
913 Anemonefish use sialic acid metabolism as Trojan horse to avoid giant sea anemone stinging
Roux, N.; Delannoy, C.; Yu, S.-Y.; Miura, S.; Carlu, L.; Besseau, L.; Nakagawa, T.; Sato, C.; Kitajima, K.; Guerardel, Y.; Laudet, V.
10.1101/2024.04.22.590498 — zoology — Posted on 2024-04-26
915 Molecular and physiological characterization of brassinosteroid receptor BRI1 mutants in Sorghum bicolor
Rico-Medina, A.; Blasco-Escamez, D.; Fontanet-Manzaneque, J. B.; Laibach, N.; Lozano-Elena, F.; Martignago, D.; Cano-Delgado, A.
10.1101/2024.04.22.590590 — plant biology — Posted on 2024-04-26
916 The Discovery of Small Molecule Inhibitors of cFLIP that Sensitise Tumour Cells to TRAIL
Giancotti, G.; French, R.; Olivia, H.; Lee, K. Y.; Robinson, T.; Ribeiro da Silva, A. M.; Varnava, A.; MacFarlane, M.; Clarkson, R. W. E.; Westwell, A. D.; Brancale, A.
10.1101/2024.04.22.590574 — cancer biology — Posted on 2024-04-26
919 Pretrainable Geometric Graph Neural Network for Antibody Affinity Maturation
Cai, H.; Zhang, Z.; Wang, M.; Zhong, B.; Li, Q.; Zhong, Y.; Wu, Y.; Ying, T.; Tang, J.
10.1101/2023.08.10.552845 — bioinformatics — Posted on 2024-04-26
920 Decoding Missense Variants by Incorporating Phase Separation via Machine Learning
Feng, M.; Wei, X.; Zheng, X.; Liu, L.; Lin, L.; Xia, M.; He, G.; Shi, Y.; Lu, Q.
10.1101/2024.04.01.587546 — bioinformatics — Posted on 2024-04-26
921 G-PLIP: Knowledge graph neural network for structure-free protein-ligand bioactivity prediction
Crouzet, S. J.; Lieberherr, A. M.; Atz, K.; Nilsson, T.; Sach-Peltason, L.; Muller, A. T.; Dal Peraro, M.; Zhang, J. D.
10.1101/2023.09.01.555977 — bioinformatics — Posted on 2024-04-26
922 DysRegNet: Patient-specific and confounder-aware dysregulated network inference
Kersting, J.; Lazareva, O.; Louadi, Z.; Baumbach, J.; Blumenthal, D.; List, M.
10.1101/2022.04.29.490015 — bioinformatics — Posted on 2024-04-26
924 A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system
Aleman, J.; K, R.; Wiegand, C.; Schurdak, M. E.; Vernetti, L.; Gavlock, D.; Reese, C.; DeBiasio, R.; LaRocca, G.; Angarita, Y. D.; Gough, A.; Soto-Gutierrez, A.; Behari, J.; Miedel, M. T.; Stern, A. M.; Banerjee, I.; Taylor, D. L.
10.1101/2024.04.22.590598 — bioengineering — Posted on 2024-04-26
925 Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by 64Cu-CTS PET Imaging
Baark, F.; Michaels, A.; Waters, E.; Rigby, A.; Kim, J.; Yu, Z.; Pell, V.; Clark, J.; Blower, P.; Eykyn, T. R.; Southworth, R.
10.1101/2024.04.22.590587 — bioengineering — Posted on 2024-04-26
928 Characterisation and comparison of semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility
Mowla, S.; Farahani, L.; Tharakan, T.; Davies, R.; Correia, G. D.; Lee, Y. S.; Kundu, S.; Khanjani, S.; Sindi, E.; Rai, R.; Regan, L.; Khalifa, D.; Henkel, R.; Minhas, S.; S. Dhillo, W.; Ben Nagi, J.; Bennett, P.; MacIntrye, D. A.; Jayasena, C. N.
10.1101/2024.02.18.580923 — microbiology — Posted on 2024-04-26
929 Pleasurable music activates cerebral μ-opioid receptors: A combined PET-fMRI study
Putkinen, V. J.; Seppala, K.; Harju, H.; Hirvonen, J.; Karlsson, H.; Nummenmaa, L.
10.1101/2024.04.10.588805 — neuroscience — Posted on 2024-04-26
932 Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate isprevented by blockade of the epidermal growth factor receptor
Shah, S. N.; Knausenberger, T. B.-A.; Pontifex, M.; Connell, E.; Le Gall, G.; Hardy, T. A.; Randall, D. W.; McCafferty, K.; Yaqoob, M. M.; Solito, E.; Müller, M.; Stachulski, A. V.; Glen, R. C.; Vauzour, D.; Hoyles, L.; McArthur, S.
10.1101/2022.11.12.516113 — systems biology — Posted on 2024-04-26
933 Psychobiological regulation of plasma and saliva GDF15 dynamics in health and mitochondrial diseases
Huang, Q.; Trumpff, C.; Monzel, A. S.; Rausser, S.; Haahr, R.; Devine, J.; Liu, C. C.; Kelly, C.; Thompson, E.; Kurade, M. S.; Michelson, J.; Shaulson, E. D.; Li, S.; Engelstad, K.; Tanji, K.; Lauriola, V.; Wang, T.; Wang, S.; Zuraikat, F. M.; St-Onge, M.-P.; Kaufman, B. A.; Sloan, R.; Juster, R.-P.; Marsland, A. L.; Gouspillou, G.; Hirano, M.; Picard, M.
10.1101/2024.04.19.590241 — physiology — Posted on 2024-04-26
934 Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy
Nitta, Y.; Osaka, J.; Maki, R.; Hakeda-Suzuki, S.; Suzuki, E.; Ueki, S.; Suzuki, T.; Sugie, A.
10.1101/2023.03.17.533056 — pathology — Posted on 2024-04-26
935 De Novo Genome assembly of the Caucasian dwarf goby Knipowitschia cf. caucasica, a new alien Gobiidae invadingthe River Rhine
Schoenle, A.; Guiglielmoni, N.; Mainz, T.; Greve, C.; Hamadou, A. B.; Heermann, L.; Borcherding, J.; Waldvogel, A.-M.
10.1101/2024.04.22.590508 — genomics — Posted on 2024-04-26
937 Genome-wide association study reveals multiple loci for analgesia and opioid consumption behaviors associated with heroin vulnerability in outbred rats
Kuhn, B. N.; Cannella, N. N.; Sanchez, T.; Peng, B.; Chitre, A.; Polesskaya, O.; Gupta, A.; Solberg-Woods, L.; Chung, D.; Ciccocioppo, R.; Kalivas, P.; Palmer, A. A.
10.1101/2024.02.27.582340 — genetics — Posted on 2024-04-26
938 A highly efficient gene disruption strategy reveals lipid co-regulatory networks
Harayama, T.; Hashidate-Yoshida, T.; FLEURIOT, L.; Aguilera-Romero, A.; Hamano, F.; Ri, K.; Morimoto, R.; Debayle, D.; Shimizu, T.; Riezman, H.
10.1101/2020.11.24.395632 — genetics — Posted on 2024-04-26
941 Lipopeptide antibiotics disrupt interactions of undecaprenyl phosphate with UptA
Oluwole, A. O.; Kalmankar, N.; Guida, M.; Bennett, J. L.; Poce, G.; Bolla, J. R.; Robinson, C. V.
10.1101/2024.04.02.587717 — molecular biology — Posted on 2024-04-26
944 A comparative study between a power and a connectivity sEEG biomarker for seizure-onset zone identification in temporal lobe epilepsy
Vila-Vidal, M.; Craven-Bartle Corominas, F.; Gilson, M.; Zucca, R.; Principe, A.; Rocamora, R.; Deco, G.; Tauste Campo, A.
10.1101/2023.11.23.568472 — neuroscience — Posted on 2024-04-26
945 Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species
Phillips, R. A.; Oh, S.; Bach, S. V.; Du, Y.; Miller, R. A.; Kleinman, J. E.; Hyde, T. M.; Hicks, S. C.; Page, S. C.; Martinowich, K.
10.1101/2024.04.22.590602 — neuroscience — Posted on 2024-04-26
946 Characterizing the temporal dynamics and maturation of resting-state activity: an EEG microstate study in preterm and full-term infants.
Adibpour, P.; Nasser, H.; Pedoux, A.; Devisscher, L.; Elbaz, N.; Ghozland, C.; Hinnekens, E.; Neumane, S.; Kabdebon, C.; Lefebvre, A.; Kaminska, A.; Hertz-Pannier, L.; Heneau, A.; Sibony, O.; Alison, M.; Delanoe, C.; Delorme, R.; Barbu-Roth, M.; Biran, V.; Dubois, J.
10.1101/2024.03.19.585608 — neuroscience — Posted on 2024-04-26
948 Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling
Ogunlusi, O.; Sarkar, M.; Chakrabarti, A.; Boland, D.; Nguyen, T.; Sampson, J.; Nguyen, C.; Falis, D.; Jones-Hall, Y.; Fu, L.; Mallick, B.; Keene, A.; Jones, J.; Sarkar, T. R.
10.1101/2024.03.19.585534 — cancer biology — Posted on 2024-04-26
949 Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within Interleukin-6 family cytokines
Huber, A.; Allam, A. H.; Dijkstra, C.; Thiem, S.; Huynh, J.; Poh, A. R.; Konecnik, J.; Jacob, S. P.; Busuttil, R.; Liao, Y.; Chasinga, D.; Shi, W.; Alorro, M. G.; Forrow, S.; Tauriello, D. V. F.; Batlle, E.; Bousssioutas, A.; Williams, D. S.; Buchert, M.; Ernst, M.; Eissmann, M. F.
10.1101/2024.04.22.590499 — cancer biology — Posted on 2024-04-26
950 Ultrasound Imaging Enables Longitudinal Tracking of Vascular Changes that Correlate with Immune Response After Radiotherapy
Martello, S. E.; Xia, J.; Kusunose, J.; Hacker, B. C.; Mayeaux, M. A.; Lin, E. J.; Hawkes, A.; Singh, A.; Caskey, C. F.; Rafat, M.
10.1101/2023.08.04.552076 — cancer biology — Posted on 2024-04-26
953 Specific oncogene activation of the cell of origin in mucosal melanoma
Babu, S.; Chen, J.; Robitschek, E.; Baron, C. S.; McConnell, A.; Wu, C.; Dedeilia, A.; Sade-Feldman, M.; Modhurima, R.; Manos, M. P.; Chen, K. Y.; Cox, A. M.; Ludwig, C. G.; Yang, J.; Kellis, M.; Buchbinder, E. I.; Hacohen, N.; Boland, G. M.; Abraham, B. J.; Liu, D.; Zon, L. I.; Insco, M. L.
10.1101/2024.04.22.590595 — cancer biology — Posted on 2024-04-26
956 Crystal structure of a bacterial photoactivated adenylate cyclase determined at room temperature by serial femtosecond crystallography
Kapetanaki, S. M.; Coquelle, N.; von Stetten, D.; Byrdin, M.; Rios-Santacruz, R.; Bean, R.; Bielecki, J.; Boudjelida, M.; Fekete, Z.; Grime, G. W.; Han, H.; Hatton, C.; Kantamneni, S.; Kharitonov, K.; Kim, C.; Kloos, M.; Koua, F. H. M.; de Diego Martinez, I.; Melo, D.; Rane, L.; Round, A.; Round, E.; Sarma, A.; Schubert, R.; Schulz, J.; Sikorski, M.; Vakili, M.; Valerio, J.; Vitas, J.; de Wijn, R.; Wrona, A.; Zala, N.; Pearson, A.; Dorner, K.; Schiro, G.; Garman, E. F.; Lukacs, A.; Weik, M.
10.1101/2024.04.21.590439 — biophysics — Posted on 2024-04-26
957 Force-Enhanced Sensitive Detection of New DNA-Interactive Agents from Microorganisms at the Single-Molecule Level
Liu, T.; Cai, T.; Huo, J.; Liu, H.; Li, A.; Yin, M.; Mei, Y.; Zhou, Y.; Fan, S.; Lu, Y.; Wan, L.; You, H.; Cai, X.
10.1101/2024.04.22.590585 — biophysics — Posted on 2024-04-26
959 Quantum Chemistry in a Pocket: A Multifaceted Tool to Link Structure and Activity
Menezes, F.; Popowicz, G. M.; Froehlich, T.; Napolitano, V.; Rioton, S.; Olmos, J. D. J.; Dubin, G.
10.1101/2024.04.22.590615 — bioinformatics — Posted on 2024-04-26
961 Deep learning versus geometric morphometrics for archaeobotanical domestication study and subspecific identification
Bonhomme, V.; Bouby, L.; Claude, J.; Dham, C.; Gros-Balthazard, M.; Ivorra, S.; Jeanty, A.; Pagnoux, C.; Pastor, T.; Terral, J.-F.; Evin, A.
10.1101/2023.09.15.557939 — bioinformatics — Posted on 2024-04-26
962 FREDDIE: A comprehensive tool for detecting exonization of retrotransposable elements in short and long RNA sequencing data
Mercuri, R. L. V.; Miller, T. L. A.; dos Santos, F. F.; de Lima, M. F.; Rangel-Pozzo, A.; Galante, P. A. F.
10.1101/2024.04.22.590610 — bioinformatics — Posted on 2024-04-26
965 Early-life stress induces persistent astrocyte dysfunction resulting in fear generalisation
Guayasamin, M.; Depaauw-Holt, L. R.; Adedipe, I. I.; Ghenissa, O.; Vaugeois, J.; Duquenne, M.; Rogers, B.; Latraverse-Arquilla, J.; Peyrard, S.; Bosson, A.; Murphy-Royal, C.
10.1101/2022.12.11.519598 — neuroscience — Posted on 2024-04-26
967 Tissue and cellular spatiotemporal dynamics in colon aging
Daly, A. C.; Cambuli, F.; Aijo, T.; Lotstedt, B.; Marjanovic, N.; Kuksenko, O.; Smith-Erb, M.; Fernandez, S.; Domovic, D.; Van Wittenberghe, N.; Drokhlyansky, E.; Griffin, G. K.; Phatnani, H.; Bonneau, R.; Regev, A.; Vickovic, S.
10.1101/2024.04.22.590125 — systems biology — Posted on 2024-04-26
968 Forces directing the systemic correlations of cell migration
De la Fuente, I. M.; Pujante, J. C.; Camino-Pontes, B.; Fedetz, M.; Bringas, C.; Perez-Samartin, A.; Perez-Yarza, G.; Lopez, J. I.; Malaina, I.; Cortes, J.
10.1101/2024.04.22.590476 — systems biology — Posted on 2024-04-26
969 Therapeutic Activity of Resolvin D1 (RvD1) in Murine MASH
Navarro-Corcuera, A.; Zhu, Y.; Ma, F.; Gupta, N.; Asplund, H.; Yuan, F.; Friedman, S.; Sansbury, B. E.; Huang, X.; Cai, B.
10.1101/2024.04.22.590633 — pharmacology and toxicology — Posted on 2024-04-26
970 Resolving and Quantifying Viral-Like Particles via Blind Deconvolution
Figueroa, J. L.; Bellanger, M.; Fulghum, B.; Visscher, P. T.; White, R. A.
10.1101/2024.04.21.590467 — bioinformatics — Posted on 2024-04-26
974 Figeno: multi-region genomic figures with long-read support
Sollier, E.; Heilmanm, J.; Gerhauser, C.; Scherer, M.; Plass, C.; Lutsik, P.
10.1101/2024.04.22.590500 — bioinformatics — Posted on 2024-04-26
975 Towards anchoring evolutionary fitness for protein stability with virtual chemical environment recovery
Nie, Z.; Ma, Y.; Chen, J.; Liu, Y.; Liu, Z.; Yang, P.; Xu, F.; Huang, X.; Yin, F.; Li, Z.; Fu, J.; Ren, Z.; Zhang, W.-B.; Gao, W.; Tian, Y.
10.1101/2024.04.22.590665 — bioinformatics — Posted on 2024-04-26
978 WITHDRAWN: Reproductive biology of farmed lumpfish (Cyclopterus lumpus): Gonadal development and associated profiles of selected endocrine factors.
Mlingi, F. T.; Puvanendran, V.; Burgerhout, E.; Guercini, E.; Mommens, M.; Hansen, O. J.; Miguez, M. F.; Presa, P.; Tveiten, H.; Tomkiewicz, J.; Kjorsvik, E.
10.1101/2023.06.16.545335 — animal behavior and cognition — Posted on 2024-04-26
982 Atlas of Cynomolgus Macaque Hematopoiesis
Oshima, S.; Sinha, R.; Takeuchi, K.; Mizuta, K.; Nakamura, T.; Ito, R.; Kawamoto, I.; Iwatani, C.; Nakaya, M.; Tsuchiya, H.; Bhagat, S.; Tsukiyama, T.; Takaori-Kondo, A.; Saitou, M.; Murakawa, Y.; Yamamoto, R.
10.1101/2024.04.22.590220 — cell biology — Posted on 2024-04-26
983 Global mapping of the Chlamydia trachomatis conventional secreted effector-host interactome reveals CebN interacts with nucleoporins and Rae1 to impede STAT1 nuclear translocation.
Steiert, B.; Andersen, S. E.; McCaslin, P. N.; Elwell, C. A.; Faris, R.; Tijerina, X.; Smith, P.; Eldridge, Q.; Imai, B. S.; Arrington, J. V.; Yau, P. M.; Mirrashidi, K. M.; Johnson, J. R.; Verschueren, E.; Von Dollen, J.; Jang, G. M.; Krogan, N. J.; Engel, J. N.; Weber, M. M.
10.1101/2024.04.25.587017 — microbiology — Posted on 2024-04-26
985 Streptococcus pneumoniae infection of lung epithelial cells induces internalization of surface GPI-anchored proteins through pneumolysin-mediated activation of host Rho GTPases
Lee, N.; Bhalla, M.; Pereira, J. M.; Clark, S.; Roggensack, S. E.; Lovy, A.; Pereira, M. J.; Arroyo, G.; Adams, W.; Camilli, A.; Tweten, R. K.; Leong, J. M.; Sousa, S.; Bou Ghanem, E.
10.1101/2024.04.17.590015 — microbiology — Posted on 2024-04-26
986 The attenuation of activity-based anorexia by obese adipose tissue transplant is AgRP neuron-dependent.
Yoon, D. J.; Zhang, J.; Zapata, R.; Ulivieri, M.; Libster, A. M.; McMurray, M. S.; Osborn, O.; Dulawa, S. C.
10.1101/2024.04.23.590824 — neuroscience — Posted on 2024-04-26
988 A flexible intracortical brain-computer interface for typing using finger movements
Shah, N. P.; Willsey, M. S.; Hahn, N.; Kamdar, F.; Avansino, D. T.; Fan, C.; Hochberg, L. R.; Willett, F. R.; Henderson, J. M.
10.1101/2024.04.22.590630 — neuroscience — Posted on 2024-04-26
990 Cellular and molecular changes in the human osteoarthritic and aging hip pulvinar
Tilouche, B.; Farhat, S.; Short, S.; Somyk, M.; Beaule, P.; Carsen, S.; Grammatopoulos, G.; Coutu, D. L.
10.1101/2024.04.21.590119 — physiology — Posted on 2024-04-26
991 Organ specificity and commonality of epigenetic aging in low- and high-running capacity rats
Kawamura, T.; Kerepesi, C.; Torma, F.; Bori, Z.; Zhou, L.; Bakonyi, P.; Kolonics, A.; Balogh, L.; Higuchi, M.; Koch, L. G.; Britton, S. L.; Koltai, E.; Radak, Z.
10.1101/2024.04.21.590009 — physiology — Posted on 2024-04-26
996 Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation
Arya, S. B.; Collie, S. P.; Xu, Y.; Fernandez, M.; Sexton, J. Z.; Mosalaganti, S.; Coulombe, P. A.; Parent, C. A.
10.1101/2024.04.21.590456 — immunology — Posted on 2024-04-26
998 Glia-Mediated Antigen Presentation In The Retina During Degeneration
Intonti, S.; Kokona, D.; Zinkernagel, M. S.; Stein, J. V.; Enzmann, V.; Conedera, F. M.
10.1101/2024.04.21.590440 — neuroscience — Posted on 2024-04-25
1000 Bridging verbal coordination and neural dynamics
Mohamed, I. S.; Mercier, M. R.; Trebuchon, A.; Morillon, B.; Lancia, L.; Schon, D.
10.1101/2024.04.23.590817 — neuroscience — Posted on 2024-04-25
1001 A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams Syndrome
Zhao, X.; Sun, Q.; Shou, Y.; Chen, W.; Wang, M.; Qu, W.; Huang, X.; Li, Y.; Wang, C.; Gu, Y.; Ji, C.; Shu, Q.; Li, X.
10.1101/2024.04.25.591131 — neuroscience — Posted on 2024-04-25
1002 Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses
Zhai, S.; Otsuka, S.; Xu, J.; Clarke, V. R. J.; Tkatch, T.; Wokosin, D.; Xie, Z.; Tanimura, A.; Agarwal, H. K.; Ellis-Davies, G. C. R.; Contractor, A.; Surmeier, D. J.
10.1101/2024.04.24.590962 — neuroscience — Posted on 2024-04-25
1008 Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline
Cheng, K.; Seita, Y.; Whelan, E. C.; Yokomizo, R.; Hwang, Y. S.; Rotolo, A.; Krantz, I. D.; Kaur, M.; Ginsberg, J. P.; Lal, P.; Luo, X.; Pierorazio, P. M.; Linn, R. L.; Ryeom, S.; Sasaki, K.
10.1101/2024.04.20.590406 — developmental biology — Posted on 2024-04-25
1009 Post-translational cleavage of Mei5 of Dmc1 mediator, Mei5-Sae3 complex, in yeast meiosis
Mwaniki, S.; Sawant, P.; Osemwenkhae, O. P.; Fujita, Y.; Ito, M.; Furukohri, A.; Shinohara, A.
10.1101/2024.04.25.591189 — molecular biology — Posted on 2024-04-25
1010 Improved mouse models of the small intestine microbiota using region-specific sampling from humans
Culver, R.; Spencer, S. P.; Violette, A.; Lemus Silva, E.; Takeuchi, T.; Nafarzadegan, C.; Higginbottom, S.; Shalon, D.; Sonnenburg, J.; Huang, K. C.
10.1101/2024.04.24.590999 — microbiology — Posted on 2024-04-25
1011 Limiting mitochondrial-derived ATP transfer to the cytosol enhances T-cell activation
Yosef, O.; Cohen-Daniel, L.; Shamriz, O.; Bar-On, Z.; Saragovi, A.; Abramovich, I.; Agranovich, B.; Lutz, V.; Tam, J.; Permyakova, A.; Gottlieb, E.; Huber, M.; Berger, M.
10.1101/2024.04.21.590436 — immunology — Posted on 2024-04-25
1012 Connectomic Analysis of Mitochondria in the Central Brain of Drosophila
Rivlin, P. K.; Januszewski, M.; Longden, K. D.; Neace, E.; Scheffer, L. K.; Ordish, C.; Clements, J.; Umayam, L.; Yakal, E. A.; Phillips, E.; Walsh, C.; Smith, N.; Takemura, S.; Plaza, S. M.; Berg, S.
10.1101/2024.04.21.590464 — neuroscience — Posted on 2024-04-25
1013 A Drosophila model for mechanistic investigation of tau protein spread
Bankapalli, K.; Thomas, R. E.; Vincow, E. S.; Milstein, G.; Fisher, L. V.; Pallanck, L. J.
10.1101/2024.04.21.590466 — neuroscience — Posted on 2024-04-25
1016 Imaging the large-scale and cellular cortical response to focal traumatic brain injury in mouse neocortex
Bibineyshvili, Y.; Vajtay, T. J.; Salsabilian, S.; Fliss, N.; Suvarnakar, A.; Fang, J.; Teng, S.; Alder, J.; Najafizadeh, L.; Margolis, D. J.
10.1101/2024.04.24.590835 — neuroscience — Posted on 2024-04-25
1018 Accelerated spike-triggered non-negative matrix factorization reveals coordinated ganglion cell subunit mosaics in the primate retina
Zapp, S. J.; Khani, M. H.; Schreyer, H. M.; Sridhar, S.; Ramakrishna, V.; Krueppel, S.; Mietsch, M.; Protti, D. A.; Karamanlis, D.; Gollisch, T.
10.1101/2024.04.22.590506 — neuroscience — Posted on 2024-04-25
1020 Theta oscillons in behaving rats
Zobaer, M. S.; Lotfi, N.; Domenico, C. M.; Hoffman, C.; Perotti, L.; Ji, D.; Dabaghian, Y.
10.1101/2024.04.21.590487 — neuroscience — Posted on 2024-04-25
1025 Mating proximity blinds threat perception.
Cazale Debat, L.; Scheunemann, L.; Day, M.; Fernandez d V Alquicira, T.; Dimtsi, A.; Zhang, Y.; Blackburn, L. A.; Ballardini, C. H. M.; Greenin Whitehead, K.; Reynolds, E.; Lin, A. C.; Owald, D.; Rezaval, C.
10.1101/2024.04.23.590677 — neuroscience — Posted on 2024-04-25
1027 Development of a noninvasive olfactory stimulation fMRI system in marmosets
Yurimoto, T.; Seki, F.; Yamada, A.; Okajima, J.; Yambe, T.; Takewa, Y.; Kamioka, M.; Inoue, T.; Inoue, Y.; Sasaki, E.
10.1101/2024.04.21.590223 — physiology — Posted on 2024-04-25
1028 Structural basis for bispecific antibody design: arrangement of domain linkage produces activity enhancement
Sato, K.; Uehara, S.; Tsugita, A.; Ishiyama, S.; Maejima, A.; Nakahara, I.; Nazuka, M.; Matsui, T.; Gatsogiannis, C.; Yokoyama, T.; Kumagai, I.; Makabe, K.; Asano, R.; Tanaka, Y.
10.1101/2024.04.25.591206 — biochemistry — Posted on 2024-04-25
1029 Development of Allosteric Small Molecule APOBEC3B Inhibitors from In Silico Screening
Jones, K. F.; Demir, O.; Wyllie, M. K.; Grillo, M. J.; Morris, C.; Hirakis, S. P.; Kardile, R. D.; Walters, M. A.; Harris, R. S.; Amaro, R. E.; Harki, D. A.
10.1101/2024.04.25.591187 — biochemistry — Posted on 2024-04-25
1032 An adapted typology of tree-related microhabitats including tropical forests
Nusser, R.; Bianco, G.; Kraus, D.; Larrieu, L.; Feldhaar, H.; Schleuning, M.; Mueller, J.
10.1101/2024.04.20.590405 — ecology — Posted on 2024-04-25
1036 The transcription factor ZNF469 regulates collagen production in liver fibrosis
Steinhauser, S.; Estoppey, D.; Buehler, D. P.; Xiong, Y.; Pizzato, N.; Rietsch, A.; Wu, F.; Leroy, N.; Wunderlin, T.; Claerr, I.; Tropberger, P.; Mueller, M.; Davison, L. M.; Sheng, Q.; Bergling, S.; Wild, S.; Moulin, P.; Liang, J.; English, W. J.; Williams, B.; Knehr, J.; Altorfer, M.; Reyes, A.; Mickanin, C.; Hoepfner, D.; Nigsch, F.; Frederiksen, M.; Flynn, C. R.; Fodor, B. D.; Brown, J. D.; Kolter, C.
10.1101/2024.04.25.591188 — molecular biology — Posted on 2024-04-25
1037 Modulating Cardiac Energetics in Cardio-Metabolic Syndromes: A mechanistic, hyperpolarized MR Trial of Ninerafaxstat Treatment
Hundertmark, M. J.; Siu, A. G.; Matthews, V.; Lewis, A. J.; Grist, J. T.; Patel, J.; Chamberlin, P.; Sarwar, R.; Yavari, A.; Dehbi, H.-M.; Rao, P.; Shi, X.; Zheng, S.; Robbins, J. M.; Gerszten, R. E.; Frenneaux, M. P.; Valkovic, L.; Miller, J. J.; Neubauer, S.; Tyler, D. J.; Rider, O. J.
10.1101/2024.04.24.591019 — molecular biology — Posted on 2024-04-25
1043 Detection of tomato brown rugose fruit virus in environmental residues: the importance of contextualizing test results
Giesbers, A. K.; Vogel, E.; Skelton, A.; Zisi, Z.; Wildhagen, M.; Loh, Y. L.; Ghijselings, L.; Groothuismink, J.; Westenberg, M.; Matthijnssens, J.; Roenhorst, A.; Vos, C.; Fox, A.; Botermans, M.
10.1101/2024.04.25.591117 — microbiology — Posted on 2024-04-25
1044 Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses
Ruiz, F.; Foreman, W.; Lilly, M.; Baharani, V. A.; Depierreux, D. M.; Chohan, V.; Taylor, A. L.; Guenthoer, J.; Ralph, D.; Matsen, F. A.; Chu, H. Y.; Bieniasz, P. D.; Cote, M.; Starr, T. N.; Overbaugh, J.
10.1101/2024.04.24.590836 — immunology — Posted on 2024-04-25
1045 Sex differences in vaccine induced immunity and protection against Mycobacterium tuberculosis
Parvathy, G. H.; Bhandiwad, D.; Eggers, L.; von Borstel, L.; Behrends, J.; Hein, M.; Hertz, D.; Marschner, J.; Orinska, Z.; Kaufmann, S. H. E.; Flores-Valdez, M. A.; Lotter, H.; Schneider, B. E.
10.1101/2024.04.20.590403 — immunology — Posted on 2024-04-25
1046 Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections.
Osowicki, J.; Frost, H. R.; Azzopardi, K. I.; Whitcombe, A. L.; McGregor, R.; Carlton, L. H.; Baker, C.; Fabri, L.; Pandey, M.; Good, M. F.; Carapetis, J. R.; Walker, M. J.; Smeesters, P. R.; Licciardi, P. V.; Moreland, N. J.; Hill, D. L.; Steer, A. C.
10.1101/2024.04.20.590388 — immunology — Posted on 2024-04-25
1050 Different molecular recognition by three domains of the full-length GRB2 to SOS1 proline-rich motifs and EGFR phosphorylated sites
Tateno, K.; Ando, T.; Tabata, M.; Sugasawa, H.; Hayashi, T.; Sayeesh, P. M.; Inomata, K.; Mikawa, T.; Ito, Y.; Ikeya, T.
10.1101/2024.04.20.590390 — biophysics — Posted on 2024-04-25
1053 T2R14 mediated antimicrobial responses through interactions with CFTR
Gupte, T.; Singh, N.; Bhatia, V.; Arora, K.; Amiri, S.; Fernyhough, P.; NAREN, A.; Dakshinamurti, S.; Chelikani, P.
10.1101/2024.04.25.591203 — biochemistry — Posted on 2024-04-25
1055 Cryo-EM Structure of HRSL Domain Reveals Activating Crossed Helices at the Core of GCN2
Solorio - Kirpichyan, K.; Golovenko, D.; Korostelev, A.; Yan, N.; Korennykh, A.
10.1101/2024.04.24.591037 — biochemistry — Posted on 2024-04-25
1057 The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients
Malboubi, M.; Esteki, M. H.; Korsak, L. I.; Petrie, R. J.; Moeendarbary, E.; Charras, G.
10.1101/2024.04.22.590593 — biophysics — Posted on 2024-04-25
1059 Exploring transient states of PAmKate to enable improved cryogenic single-molecule imaging
Perez, D.; Dowlatshahi, D. P.; Azaldegui, C. A.; Dahlberg, P. D.; Moerner, W. E.
10.1101/2024.04.24.590965 — biophysics — Posted on 2024-04-25
1061 Identification of MYC synthetic lethal genes and networks
Martin, T. D.; Choi, M. Y.; Patel, R. S.; Liang, A. C.; Li, M. Z.; Elledge, S. J.
10.1101/2024.04.25.590465 — cancer biology — Posted on 2024-04-25
1064 Variations in clustering of multielectrode local field potentials in the motor cortex of macaque monkeys during a reach-and-grasp task
Chambellant, F.; Falaki, A.; Moreau-Debord, I.; French, R.; Serrano, E.; Quessy, S.; Dancause, N.; Thomas, E.
10.1101/2024.03.20.585852 — neuroscience — Posted on 2024-04-25
1067 Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut
Touhara, K. K.; Rossen, N. D.; Deng, F.; Chu, T.; Harrington, A. M.; Garcia Caraballo, S.; Brizuela, M.; O'Donnell, T.; Cil, O.; Brierley, S. M.; Li, Y.; Julius, D.
10.1101/2024.02.06.579180 — physiology — Posted on 2024-04-25
1068 Magnetogenetic cell activation using endogenous ferritin
Pomeranz, L. E.; Li, R.; Yu, X. A.; Kelly, L.; Hassanzadeh, G.; Molina, H.; Gross, D.; Brier, M. I.; Vaisey, G.; Wang, P.; Jimenez-Gonzalez, M.; Garcia-Ocana, A.; Dordick, J.; Friedman, J. M.; Stanley, S. A.
10.1101/2023.06.20.545120 — bioengineering — Posted on 2024-04-25
1069 Late-Stage Skeletal Muscle Transcriptome in Duchenne muscular dystrophy shows a BMP4-Induced Molecular Signature
Sothers, H.; Hu, X.; Crossman, D. K.; Si, Y.; Alexander, M.; McDonald, M.-L.; King, P. H.; Lopez, M. A.
10.1101/2024.04.19.590266 — bioinformatics — Posted on 2024-04-25
1070 Sanger validation of WGS variants - when to?
Kopernik, A. A.; Zobkova, G. Y.; Doroschuk, N.; Smirnova, A. V.; Molodtsova-Zolotukhina, D. V.; Sagaydak, O.; Ryzhkova, O. P.; Kutsev, S. I.; Groznova, O.; Melikyan, L.; Bondarchuk, E.; Woroncow, M.; Albert, E.; Bogdanov, V. P.; Volchkov, P. Y.
10.1101/2024.04.19.590340 — genomics — Posted on 2024-04-25
1076 Mapping polarization-sensitive optical coherence tomography and ultra-high-field diffusion MRI in the macaque brain
Pisharady, P. K.; Yeatts, M.; Farooq, H.; Johnson, M.; Harel, N.; Moeller, S.; Zimmermann, J.; Yacoub, E.; Ugurbil, K.; Heilbronner, S. R.; Lenglet, C.; Akkin, T.
10.1101/2024.04.19.590326 — neuroscience — Posted on 2024-04-25
1077 A Comparison of Techniques to Determine Active Motor Threshold for Quadriceps Transcranial Magnetic Stimulation Research
Beausejour, J. P.; Rusch, J.; Knowles, K. S.; Pagan, J. I.; Chaput, M.; Norte, G. E.; DeFreitas, J. M.; Stock, M. S.
10.1101/2024.04.19.590327 — neuroscience — Posted on 2024-04-25
1081 The Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy
Wang, W.; Li, E.; Zou, J.; Qu, C.; Ayala, J.; Wen, Y.; Islam, M. S.; Weintraub, N. L.; Fulton, D. J.; Liang, Q.; Zhou, J.; Liu, J.; Li, J.; Sun, Y.; Su, H.
10.1101/2024.02.24.581168 — pathology — Posted on 2024-04-25
1084 Information theory for data-driven model reduction in physics and biology
Schmitt, M. S.; Koch-Janusz, M.; Fruchart, M.; Seara, D. S.; Rust, M.; Vitelli, V.
10.1101/2024.04.19.590281 — biophysics — Posted on 2024-04-25
1085 Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters
Reddy, K. D.; Rasool, B.; Akher, F. B.; Kutlesic, N.; Pant, S.; Boudker, O.
10.1101/2023.12.03.569786 — biophysics — Posted on 2024-04-25
1087 Real-time visualization reveals Mycobacterium tuberculosis ESAT-6 disrupts phagosome via fibril-mediated vesiculation
Koiri, D.; Nandi, M.; PM, A. H.; Bhausaheb, A. J.; Meher, G.; Behura, A.; Kumar, A.; Choudhary, V.; Choubey, S.; Saleem, M.
10.1101/2024.04.19.590309 — biophysics — Posted on 2024-04-25
1088 Large Language Models to process, analyze, and synthesize biomedical texts - a scoping review
Doneva, S. E.; Qin, S.; Sick, B.; Ellendorff, T.; Goldman, J.-P.; Schneider, G.; Ineichen, B. V.
10.1101/2024.04.19.588095 — bioinformatics — Posted on 2024-04-25
1089 Spherical Phenotype Clustering
Nightingale, L.; Tuersley, J.; Cairoli, A.; Howes, J.; Powell, A.; Green, D.; Strange, A.; Warchal, S.; Howell, M.
10.1101/2024.04.19.590313 — bioinformatics — Posted on 2024-04-25
1090 An aortic hemodynamic fingerprint reduced order modeling analysis reveals traits associated with vascular disease in a medical biobank
Sokolow, R.; Kissas, G.; Beeche, C.; Swago, S.; Thompson, E. W.; Viswanadha, M.; Chirinos, J.; Damrauer, S.; Perdakaris, P.; Rader, D. J.; Witschey, W. R. T.
10.1101/2024.04.19.590260 — bioengineering — Posted on 2024-04-25
1092 Atlas of Fshr Expression from Novel Reporter Mice
Chen, H.-Q.; Fang, H.; Liu, J.-T.; Chang, S.-Y.; Cheng, L.-B.; Sun, M.-X.; Feng, J.-R.; Liu, Z.; Li, X.-L.; Zhang, Y.; J. Rosen, C.; Liu, P.
10.1101/2023.11.05.565707 — cell biology — Posted on 2024-04-25
1095 Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration
Thomsen, M. S.; Kostrikov, S.; Routhe, L. J.; Johnsen, K. B.; Helgudottir, S. S.; Gudbergsson, J. M.; Andresen, T. L.; Moos, T.
10.1101/2024.04.15.589475 — neuroscience — Posted on 2024-04-25
1099 Modeling conditional distributions of neural and behavioral data with masked variational autoencoders
Schulz, A.; Vetter, J.; Gao, R.; Morales, D.; Lobato-Rios, V.; Ramdya, P.; Goncalves, P. J.; Macke, J. H.
10.1101/2024.04.19.590082 — neuroscience — Posted on 2024-04-25
1101 Genome Wide Association Studies on 7 Yield-related Traits of 183 Rice Varieties in Bangladesh
Roy, N.; Kabir, A. H.; Zahan, N.; Mouna, S. T.; Chakravarty, S.; Rahman, A. H.; Bayzid, M. S.
10.1101/2020.11.22.393074 — bioinformatics — Posted on 2024-04-25
1102 Highly accurate discovery of terpene synthases powered by machine learning reveals functional terpene cyclization in Archaea
Samusevich, R.; Hebra, T.; Bushuiev, R.; Bushuiev, A.; Calounova, T.; Smrckova, H.; Chatpatanasiri, R.; Kulhanek, J.; Perkovic, M.; Engst, M.; Tajovska, A.; Sivic, J.; Pluskal, T.
10.1101/2024.01.29.577750 — biochemistry — Posted on 2024-04-25
1103 Chromosome-level assembly of Cucumis sativus cv. 'Tokiwa' as a reference genome of Japanese cucumber
Seiko, T.; Muto, C.; Shimomura, K.; Yano, R.; Kawazu, Y.; Sugiyama, M.; Kato, K.; Tomooka, N.; Naito, K.
10.1101/2024.04.15.589484 — genomics — Posted on 2024-04-25
1104 Lineage maintenance due to assortative mating but not competitive exclusion in a sympatric sibling species pair
Irvine, M.; Stewart, Z.; Kumaran, N.; Manawaduge, C. G.; Balagawi, S.; Missenden, B.; Starkie, M.; Clarke, A. R.; Hurwood, D. A.; Prentis, P.
10.1101/2023.08.30.555036 — evolutionary biology — Posted on 2024-04-25
1105 The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila CNS.
Sukumar, S. K.; Antonydhason, V.; Molander, L.; Sandakly, J.; Kleit, M.; Umapathy, G.; Mendoza-Garcia, P.; Masudi, T.; Schlosser, A.; Nassel, D. R.; Wegener, C.; Shirinian, M.; Palmer, R.
10.1101/2023.06.02.543395 — developmental biology — Posted on 2024-04-25
1106 Lgr5+ intestinal stem cells are required for organoid survival after genotoxic injury
Lee, J.; Gleizes, A.; Takaesu, F.; Hailstock, T.; Webster, S. F.; Barker, N.; Gracz, A. D.
10.1101/2024.04.08.588400 — cell biology — Posted on 2024-04-25
1108 The intracellular bacterium Orientia tsutsugamushi hijacks the adaptor protein BICD2 for dynein-based motility
Manigrasso, G.; Saharat, K.; Kullapanich, C.; Boulanger, J.; Morgan, T. E.; Kramer, H.; Salje, J.; Carter, A. P.
10.1101/2024.04.11.589026 — microbiology — Posted on 2024-04-25
1110 Brain orchestra under spontaneous conditions: Identifying communication modules from the functional architecture of area V1
Papadopouli, M.; Koniotakis, E.; Smyrnakis, I.; Savaglio, M. A.; Psilou, E.; Brozi, C.; Palagina, G.; Smirnakis, S. M.
10.1101/2024.02.29.582364 — neuroscience — Posted on 2024-04-25
1114 The Dorsal Column Nuclei Scale Mechanical Sensitivity in Naive and Neuropathic Pain States
Upadhyay, A.; Gradwell, M. A.; Vajtay, T. J.; Conner, J.; Sanyal, A. A.; Azadegan, C.; Patel, K. R.; Thackray, J. K.; Bohic, M.; Imai, F.; Ogundare, S. O.; Yoshida, Y.; Abdus-Saboor, I.; Azim, E.; Abraira, V. E. G.
10.1101/2024.02.20.581208 — neuroscience — Posted on 2024-04-25
1118 Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling
Ogunlusi, O.; Sarkar, M.; Chakrabarti, A.; Boland, D.; Nguyen, T.; Sampson, J.; Nguyen, C.; Falis, D.; Jones-Hall, Y.; Fu, L.; Mallick, B.; Keene, A.; Jones, J.; Sarkar, T. R.
10.1101/2024.03.19.585534 — cancer biology — Posted on 2024-04-25
1119 INAEME: Integral Neoantigen Analysis with Entirety of Mutational Events
Kovacevic, V.; Milicevic, O.; Ilic Raicevic, N.; Kojicic, M.; Skundric, N.; Mijalkovic Lazic, A.; DiGiovanna, J.
10.1101/2023.09.28.559901 — bioinformatics — Posted on 2024-04-25
1122 Antibody-lectin chimeras for glyco-immune checkpoint blockade
Stark, J. C.; Gray, M. A.; Wisnovsky, S.; Ibarlucea-Benitez, I.; Lustig, M.; Riley, N. M.; Ribi, M. K.; Errington, W. J.; Bruncsics, B.; Sarkar, C. A.; Valerius, T.; Ravetch, J. V.; Bertozzi, C. R.
10.1101/2022.10.26.513931 — bioengineering — Posted on 2024-04-25
1123 A framework for quality control in quantitative proteomics
Tsantilas, K. A.; Merrihew, G. E.; Robbins, J. E.; Johnson, R. S.; Park, J.; Plubell, D. L.; Huang, E.; Riffle, M.; Sharma, V.; MacLean, B. X.; Eckels, J.; Wu, C. C.; Bereman, M. S.; Spencer, S. E.; Hoofnagle, A. N.; MacCoss, M. J.
10.1101/2024.04.12.589318 — biochemistry — Posted on 2024-04-25
1126 Recent emergence of cephalosporin resistant Salmonella Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding blaCTX-M-15 gene
Thirumoorthy, T. P.; Jacob, J. J.; V, A.; T, M. P.; Shah, B. S.; Iyer, V.; Maheshwari, G.; Trivedi, U.; Shah, A.; Patel, P.; Gaigawale, A.; M, Y.; Sathya Narayanan, P.; Mutreja, A.; Carey, M.; John, J.; Kang, G.; Veeraraghavan, B.
10.1101/2023.07.05.547856 — genomics — Posted on 2024-04-25
1129 Mapping threatened Thai bovids provides opportunities for improved conservation outcomes in Asia
Horpiencharoen, W.; Marshall, J.; Lynam, A.; Muylaert, R.; John, R. S.; Ngoprasert, D.; Godfrey, A.; Riggio, A.; Gale, G. A.; Ash, E.; Bisi, F.; Cremonesi, G.; Clements, G. R.; Yindee, M.; Shwe, N. M.; Pin, C.; Gray, T. N. E.; Aung, S. S.; Nakbun, S.; Schuttler, S. G.; Steinmetz, R.; Phoonjampa, R.; Seuaturien, N.; Phumanee, W.; Hayman, D.
10.1101/2023.08.25.554763 — ecology — Posted on 2024-04-25
1135 Newly synthesized mRNA selectively escapes translational repression following acute stress.
Zedan, M.; Schürch, A. P.; Heinrich, S.; Gomez-Garcia, P. A.; Khawaja, S.; Weis, K.
10.1101/2024.04.14.589419 — molecular biology — Posted on 2024-04-25
1136 A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis
Jyotsna, ; Sarkar, B.; Yadav, M.; Deka, A.; Markandey, M.; Sanyal, P.; Nagarajan, P.; Gaikward, N.; Ahuja, V.; Mohanty, D.; Basak, S.; Gokhale, R. S.
10.1101/2023.09.21.558851 — immunology — Posted on 2024-04-25
1138 A neurometabolic signature in the frontal cortex explains individual differences in effort-based decision-making
Barakat, A.; Clairis, N.; Brochard, J.; Pessiglione, M.; Godin, J.-P.; Cuenoud, B.; Xin, L.; Sandi, C.
10.1101/2024.01.23.576854 — neuroscience — Posted on 2024-04-25
1140 Nonlinear manifolds underlie neural population activity during behaviour
Fortunato, C.; Bennasar-Vazquez, J.; Park, J.; Chang, J. C.; Miller, L. E.; Dudman, J. T.; Perich, M. G.; Gallego, J. A.
10.1101/2023.07.18.549575 — neuroscience — Posted on 2024-04-25
1141 An acute microglial metabolic response controls metabolism and improves memory
Drougard, A.; Ma, E. H.; Wegert, V.; Sheldon, R.; Panzeri, I.; Vatsa, N.; Apostle, S.; Fagnocchi, L.; Schaf, J.; Gossens, K.; Völker, J.; Pang, S.; Bremser, A.; Dror, E.; Giacona, F.; Sagar, S.; Henderson, M. X.; Prinz, M.; Jones, R. G.; Pospisilik, J. A.
10.1101/2023.04.03.535373 — physiology — Posted on 2024-04-25
1142 Early evolution of the ecdysozoan body plan
Wang, D.; Qiang, Y.; Guo, J.; Vannier, J.; Song, Z.; Peng, J.; Zhang, B.; Sun, J.; Yu, Y.; Zhang, Y.; Zhang, T.; Yang, X.; Han, J.
10.1101/2024.01.16.575973 — paleontology — Posted on 2024-04-25
1146 Identify Non-Mutational p53 Functional Deficiency in Human Cancers
Li, Q.; Zhang, Y.; Luo, S.; Zhang, Z.; Oberg, A.; Kozono, D.; Lu, H.; Sarkaria, J. N.; Ma, L.; Wang, L.
10.1101/2022.07.28.501874 — bioinformatics — Posted on 2024-04-25
1150 Nonlinear progression across the occult transition establishes cancer lethality
Ginzel, J. D.; Chapman, H.; Sills, J. E.; Allen, E. J.; Barak, L. S.; Cardiff, R. D.; Borowsky, A. D.; Lyerly, H. K.; Rogers, B. W.; Snyder, J. C.
10.1101/2024.04.23.590826 — cancer biology — Posted on 2024-04-25
1152 Braf-mutant Schwann cells divert to a repair phenotype to induce congenital demyelinating neuropathy
Marechal, E.; Quintana, P.; Aldea, D. A.; Mondielli, G.; Bernard-Marissal, N.; Moreno, M.; Delague, V.; Weiss, L.; Barlier, A.; Etchevers, H. C.
10.1101/2024.04.24.590951 — developmental biology — Posted on 2024-04-25
1155 Transcriptional Characterization of the Stromal and Endothelial Bone Marrow Microenvironment during Progression from MGUS to Multiple Myeloma
Cenzano, I.; Cocera, M.; Bantan, A.; Larrayoz, M.; Vilas, A.; San-Martin, P.; Aguirre-Ruiz, P.; Alignani, D.; Lopez, A.; Minana, M.; Quilez Agreda, D.; Sancho Gonzalez, I.; Ruiz, J.; Lagani, V.; Tegner, J.; Martin-Subero, I.; Agirre, X.; Paiva, B.; Rodriguez-Otero, P.; Tamariz-Amador, L.-E.; San-Miguel, J.; Martinez-Climent, J. A.; Saez, B.; Hernaez, M.; Calvo, I. A.; Gomez-Cabrero, D.; Prosper, F.
10.1101/2024.04.24.589777 — cancer biology — Posted on 2024-04-25
1156 An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma
Fraire, C. R.; Desai, K.; Obalapuram, U. A.; Mendyka, L.; Rajaram, V.; Sebastian, T.; Wang, Y.; Onel, K.; Lee, J.; Chen, K. S.
10.1101/2024.04.23.590638 — cancer biology — Posted on 2024-04-25
1157 The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states
Doroszko, M.; Stockgard, R.; Yildirim, I.; Ballester Bravo, M.; Millner, T. O.; Kundu, S.; Heinold, J.; Elgendy, R.; Berglund, M.; Elfineh, L.; Krona, C.; Marino, S.; Larsson, I.; Nelander, S.
10.1101/2024.04.23.589925 — cancer biology — Posted on 2024-04-25
1158 Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators
Desai, B.; Miti, T.; Prabhakaran, S.; Miroshnychenko, D.; Henry, M.; Marusyk, V.; Gatenbee, C.; Bui, M.; Scott, J.; Altrock, P. M.; Haura, E.; Anderson, A. R. A.; Basanta, D.; Marusyk, A.
10.1101/2024.04.24.590626 — cancer biology — Posted on 2024-04-25
1170 Non-resolving neuroinflammation regulates axon regeneration in chronic spinal cord injury
Stewart, A. N.; Bosse-Joseph, C. C.; Kumari, R.; Bailey, W. M.; Park, K. A.; Slone, V. K.; Gensel, J. C.
10.1101/2024.04.19.590106 — neuroscience — Posted on 2024-04-24
1171 Combined thermodynamic and time-resolved structural analysis of interactions between AP2 and biomimetic plasma membranes provides insights into clathrin-mediated endocytosis
Maestro, A.; Zaccai, N. R.; Gonzalez-Martinez, J.-F.; Sanchez-Puga, P.; Tajuelo, J.; Rubio, M. A.; Santamaria, A.; Carrascosa-Tejedor, J.; Pereira, D.; Marin-Montesinos, I.; Gutfreund, P.; Campbell, R.; Kotar, J.; Kelly, B. T.; Cicuta, P.; Owen, D. J.
10.1101/2024.04.19.590255 — biophysics — Posted on 2024-04-24
1173 Exploring the Potential of Structure-Based Deep Learning Approaches for T cell Receptor Design
Ribeiro-Filho, H. V.; Jara, G. E.; Guerra, J. V. d. S.; Cheung, M.; Felbinger, N. R.; Pereira, J. G. C.; Pierce, B. G.; Oliveira, P. S. L.
10.1101/2024.04.19.590222 — bioinformatics — Posted on 2024-04-24
1176 LEDGF interacts with the NID of MeCP2 and modulates MeCP2 condensates
Lesire, S.; Lata, R.; Hoogvliets, Y.; Herrebosch, K.; Van De Velde, P.; Speleers, A.; Christ, F.; Van Belle, S.; Debyser, Z.
10.1101/2024.04.24.590897 — molecular biology — Posted on 2024-04-24
1177 Dual CRALBP isoforms unveiled: iPSC-derived retinal modelling and AAV2/5-RLBP1 gene transfer raise considerations for effective therapy
Damodar, K.; Dubois, G.; Guillou, L.; Mamaeva, D.; Pequignot, M.; Erkilic, N.; Sanjurjo-Soriano, C.; Boukkhadaoui, H.; Bernex, F.; Bocquet, B.; Vialeret, J.; Arsenijevic, Y.; Redmond, T. M.; Hirtz, C.; Meunier, I.; Brabet, P.; Kalatzis, V.
10.1101/2024.04.24.590768 — molecular biology — Posted on 2024-04-24
1178 Contrasting dynamics of two incursions of low pathogenicity avian influenza virus into Australia
Wille, M.; Broz, I.; Crawley, A.; Farrugia, B.; Ford, M.; Frost, M.; Grimsey, J.; Kirkland, P.; Cherrington, T.; Latimore, S.; Lynch, S.; Martin, S.; Matereke, C.; Mee, P.; Neave, M.; O'Dea, M.; Read, A.; O'Riley, K.; Stevens, V.; Tharaparan, S.; Zufan, S.; Ban de Gouvea Pedroso, S.; Grillo, V.; Breed, A.; Barr, I.; Holmes, E.; Klaassen, M.; Wong, F.
10.1101/2024.04.23.590662 — microbiology — Posted on 2024-04-24
1179 Expanding the genome information on Bacillales for biosynthetic gene cluster discovery
Song, L.; Nielsen, L. J. D.; Xu, X.; Mohie, O. S.; Nuhamunada, M.; Xu, Z.; Murphy, R.; Bodawatta, K.; Poulsen, M.; Abdulla, M. H.; Sonnenschein, E. C.; Weber, T.; Kovacs, A. T.
10.1101/2024.04.24.590912 — microbiology — Posted on 2024-04-24
1183 Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity
Rawat, M.; Padalino, G.; Yeo, T.; Brancale, A.; Fidock, D.; Hoffmann, K.; Lee, M.
10.1101/2024.04.23.590861 — microbiology — Posted on 2024-04-24
1184 Association of diet and inflammation with the vaginal microbiota of pregnant individuals with or without IBD
Vargas Robles, D.; Yan Rou, Y.; Singha, B.; Tien, J.; Purandare, M.; Rojas-Correa, M.; Madziar, C.; Picker, M.; Dumont, T.; Leftwich, H.; Frisard, C. F.; Ward, D. V.; Peter, I.; Olendzki, B.; Maldonado-Contreras, A.
10.1101/2024.04.23.590846 — microbiology — Posted on 2024-04-24
1187 A look beyond the QR code of SNARE proteins
Yadav, D.; Hacisuleyman, A.; Dergai, M.; Khalifeh, D.; Abriata, L. A.; Dal Peraro, M.; Fasshauer, D.
10.1101/2024.04.24.590896 — biochemistry — Posted on 2024-04-24
1188 Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation
Hu, Y.; Lopez, V. A.; Xu, H.; Pfister, J. P.; Song, B.; Servage, K. A.; Sakurai, M.; Jones, B. T.; Mendell, J. T.; Wang, T.; Wu, J.; Lambowitz, A. M.; Tomchick, D. R.; Pawlowski, K.; Tagliabracci, V. S.
10.1101/2024.04.24.590974 — biochemistry — Posted on 2024-04-24
1189 Enigmatic missense mutations can cause disease via creation of de novo nuclear export signals
McConville, M. R.; Thomas, T.; Beckner, R. L.; Valadez, C.; Chook, Y. M.; Chung, S. S.; Liszczak, G. P.
10.1101/2024.04.24.590854 — biochemistry — Posted on 2024-04-24
1192 The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking
Pha, K.; Mirrashidi, K.; Sherry, J.; Tran, C. J.; Herrera, C. M.; McMahon, E.; Elwell, C.; Engel, J.
10.1101/2024.04.23.590830 — microbiology — Posted on 2024-04-24
1196 A recurrent neural circuit in Drosophila deblurs visual inputs
Pang, M. M.; Chen, F.; Xie, M.; Druckmann, S.; Clandinin, T. R.; Yang, H. H.
10.1101/2024.04.19.590352 — neuroscience — Posted on 2024-04-24
1197 Deviation from typical brain activity during naturalistic stimulation predicts personality traits
Jajcay, L.; Tomecek, D.; Androvicova, R.; Fajnerova, I.; Dechterenko, F.; Rydlo, J.; Tintera, J.; Lukavsky, J.; Horacek, J.; Hlinka, J.
10.1101/2024.04.23.586759 — neuroscience — Posted on 2024-04-24
1198 HEMATO-CHEMICAL VARIATIONS- A DIAGNOSTIC TOOL FOR BABESIA, THEILERIA AND ANAPLASMA INFECTIONS IN CAPTIVE HOG DEER (AXIS PORCINUS)
Azhar, M.; Saleem, M. H.; Chaudhary, A. S.; Khan, M. R.; Khan, B. N.; Hussain, R. F.; Awan, F.; Khalid, M. M.; Nadeem, J.
10.1101/2024.04.23.588770 — pathology — Posted on 2024-04-24
1200 Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations
Sampson, J. M.; Cannon, D. A.; Duan, J.; Sergeeva, A. P.; Epstein, J. C. K.; Katsamba, P. S.; Mannepalli, S. M.; Bahna, F. A.; Adihou, H.; Gueret, S. M.; Gopalakrishnan, R.; Geschwindner, S.; Rees, D. G.; Sigurdardottir, A.; Wilkinson, T.; Dodd, R. B.; De Maria, L.; Mobarec, J. C.; Shapiro, L.; Honig, B.; Buchanan, A.; Friesner, R. A.; Wang, L.
10.1101/2024.04.22.590325 — biophysics — Posted on 2024-04-24
1202 Single-nucleus RNA/ATAC-seq Reveals SWI/SNF complex activation and allele-specific non-myocyte activation in HCM mouse models
Thottakara, T.; Padmanabhan, A.; Tanriverdi, T.; Thambidurai, T.; Diaz-RG, J. A.; Amonkar, S. R.; Olgin, J. E.; Long, C. S.; Abraham, M. R.
10.1101/2024.04.24.589078 — bioinformatics — Posted on 2024-04-24
1206 Quantifying and controlling the proteolytic degradation of cell adhesion peptides
Rozans, S. J.; Moghaddam, A. S.; Wu, Y.; Atanasoff, K.; Nino, L.; Dunne, K.; Pashuck, E. T.
10.1101/2024.04.19.590329 — bioengineering — Posted on 2024-04-24
1208 Genome-wide profiling of highly similar paralogous genes using HiFi sequencing
Chen, X.; Baker, D.; Dolzhenko, E.; Devaney, J. M.; Noya, J.; Berlyoung, A. S.; Brandon, R.; Hruska, K. S.; Lochovsky, L.; Kruszka, P.; Newman, S.; Farrow, E.; Thiffault, I.; Pastinen, T.; Kasperaviciute, D.; Gilissen, C.; Vissers, L.; Hoischen, A.; Berger, S.; Vilain, E.; Delot, E.; Genomics Research to Elucidate the Genetics of Rare Diseases (GREGoR) Consortium, ; Eberle, M. A.
10.1101/2024.04.19.590294 — genomics — Posted on 2024-04-24
1209 Global review of meta-analyses reveals key data gaps in agricultural impact studies on biodiversity in croplands
Bonfanti, J.; Langridge, J.; Avadi, A.; Casajus, N.; Chaudhary, A.; Damour, G.; Carmona, N. E.; Jones, S. K.; Makowski, D.; Mitchell, M.; Seppelt, R.; Beillouin, D.
10.1101/2024.04.19.590051 — ecology — Posted on 2024-04-24
1211 SARS-CoV-2 Omicron Envelope T9I adaptation confers resistance to autophagy
Klute, S.; Nchioua, R.; Cordsmeier, A.; Vishwakarma, J.; Koepke, L.; Alshammary, H.; Jung, C.; Hirschenberger, M.; Hoenigsperger, H.; Fischer, J.-R.; Zech, F.; Stenger, S.; Serra-Moreno, R.; Gonzalez-Reiche, A. S.; Sordillo, E. M.; van Bakel, H.; Simon, V.; Kirchhoff, F.; Jacob, T.; Kmiec, D.; Pichlmair, A.; Ensser, A.; Sparrer, K. M.
10.1101/2024.04.23.590789 — microbiology — Posted on 2024-04-24
1212 Large circulation of a novel vesiculovirus in bats in the Mediterranean region
Luo, D. S.; Harazim, M.; Maufrais, C.; Bonas, S.; Martinkova, N.; Lalis, A.; Nakoune, E.; Adjogoua, E. V.; Douno, M.; Kadjo, B.; Lopez-Roig, M.; Pikula, J.; Shi, Z. L.; Bourhy, H.; Serra-Cobo, J.; Dacheux, L.
10.1101/2024.04.24.590417 — microbiology — Posted on 2024-04-24
1214 Macrophage-derived developmental endothelial locus 1 (DEL-1) expression promotes an immunoprotective phenotype in experimental visceral leishmaniasis.
Lukaszonek, J.; Brown, N.; Zenga, J.; Myburgh, E.; Hewitson, J. P.; Hajishengalis, G.; Chavakis, T.; Kaye, P. M.; Kourtzelis, I.
10.1101/2024.04.24.587740 — immunology — Posted on 2024-04-24
1215 Novel inhibitors of acute, axonal DLK palmitoylation are neuroprotective and avoid the deleterious side effects of cell-wide DLK inhibition
Zhang, X.; Jeong, H.; Niu, J.; Holland, S. M.; Rotanz, B.; Gordon, J. C.; Einarson, M. B.; Childers, W. E.; Thomas, G.
10.1101/2024.04.19.590310 — neuroscience — Posted on 2024-04-24
1217 Bridging genomic gaps: A versatile SARS-CoV-2 benchmark dataset for adaptive laboratory workflows
Zufan, S. E.; Judd, L. M.; Walsh, C. J.; Sait, M. L.; Ballard, S. A.; Kwong, J.; Stinear, T. P.; Seemann, T.; Howden, B. P.
10.1101/2024.04.24.587375 — genomics — Posted on 2024-04-24
1219 Evolution of a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions Affecting Activation and Autoinhibition
Snyder, L. F.; O'Brien, E. M.; Zhao, J.; Liang, J.; Zhang, Y.; Zhu, W.; Cassier, T.; Schnicker, N. J.; Zhou, X.; Gordan, R.; He, B. Z.
10.1101/2024.04.20.590343 — evolutionary biology — Posted on 2024-04-24
1223 Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis in Drosophila and Vici Syndrome patients
Deneubourg, C.; Salimi Dafsari, H.; Lowe, S.; Martinez-Cotrina, A.; Mazaud, D.; Park, S. H.; Vergani, V.; Maroofian, R.; Averdunk, L.; Ghayoor-Karimiani, E.; Jayawant, S.; Mignot, C.; Keren, B.; Peters, R.; Kamath, A.; Mattas, L.; Verma, S.; Silwal, A.; Distelmaier, F.; Houlden, H.; Antebi, A.; Jepson, J.; Jungbluth, H.; Fanto, M.
10.1101/2024.04.23.590762 — neuroscience — Posted on 2024-04-24
1226 The Single-cell Pediatric Cancer Atlas: Data portal and open-source tools for single-cell transcriptomics of pediatric tumors
Hawkins, A. G.; Shapiro, J. A.; Spielman, S. J.; Mejia, D. S.; Venkatesh Prasad, D.; Ichihara, N.; Yakovets, A.; Wheeler, K. G.; Bethell, C. J.; Foltz, S. M.; O'Malley, J.; Greene, C. S.; Taroni, J. N.
10.1101/2024.04.19.590243 — bioinformatics — Posted on 2024-04-24
1227 Extensive population structure highlights an apparent paradox of stasis in the impala (Aepyceros melampus)
Garcia-Erill, G.; Wang, X.; Rasmussen, M. S.; Quinn, L.; Khan, A.; Bertola, L. D.; Santander, C. G.; Balboa, R. F.; Ogutu, J. O.; Pecnerova, P.; Hanghoej, K.; Kuja, J.; Nursyifa, C.; Masembe, C.; Muwanika, V.; Bibi, F.; Moltke, I.; Siegismund, H. R.; Albrechtsen, A.; Heller, R.
10.1101/2024.04.19.590257 — evolutionary biology — Posted on 2024-04-24
1228 Mechanical characterization of regenerating Hydra tissue spheres
Perros, T.; Biquet-Bisquert, A.; Ben Meriem, Z.; Delarue, M.; Joseph, P.; Marcq, P.; Cochet-Escartin, O.
10.1101/2023.10.16.562504 — biophysics — Posted on 2024-04-24
1230 Pathway-enhanced Transformer-based model for robust enumeration of cell types from the cell-free transcriptome
Yan, S.; Tian, X.; Qin, Y.; Li, J.; Yang, T.; Yu, D.; Liu, W.; Sun, J.; Hu, C.; Zhou, Q.; Liu, Z.; Wang, W.-J.
10.1101/2024.02.28.582494 — bioinformatics — Posted on 2024-04-24
1231 Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3
Shiraishi, N.; Konuma, T.; Chiba, Y.; Hokazono, S.; Nakamura, N.; Islam, M. H.; Nakanishi, M.; Nishiyama, A.; Arita, K.
10.1101/2024.01.11.575164 — biochemistry — Posted on 2024-04-24
1232 Whole genomes of the amazonian Cacajao reveal complex connectivity and fast differentiation driven by high environmental dynamism
Hermosilla-Albala, N.; Silva, F. E.; Cuadros-Espinoza, S.; Fontsere, C.; Valenzuela-Seba, A.; Gut, M.; Kelley, J. L.; Ruibal-Puertas, S.; Alentorn-Moron, P.; Faella, A.; Lizano, E.; Farias, I.; Hrbek, T.; Valsecchi, J.; Gut, I. G.; Rogers, J.; Farh, K. K.-H.; Kuderna, L. F. K.; Marques-Bonet, T.; Boubli, J. P.
10.1101/2023.07.22.550156 — evolutionary biology — Posted on 2024-04-24
1233 LRBA balances antigen presentation and T-cell responses via autophagy through the binding to PIK3R4 and FYCO1
Sindram, E.; Deau, M. C.; Ligeon, L. A.; Sanchez-Martin, P.; Nestel, S.; Jung, S.; Ruf, S.; Mishra, P.; Proietti, M.; Guenther, S.; Thedieck, K.; Roussa, E.; Rambold, A.; Muenz, C.; Kraft, C.; Grimbacher, B.; Gamez-Diaz, L.
10.1101/2022.10.17.512524 — immunology — Posted on 2024-04-24
1234 Adaptive planning depth in human problem solving
Eluchans, M.; Lancia, G. L.; Maselli, A.; D'Alessandro, M.; Gordon, J.; Pezzulo, G.
10.1101/2023.05.02.539099 — neuroscience — Posted on 2024-04-24
1237 Efficiency and reliability in biological neural network architectures
Egas Santander, D.; Pokorny, C.; Ecker, A.; Lazovskis, J.; Santoro, M.; Smith, J. P.; Hess, K.; Levi, R.; Reimann, M. W.
10.1101/2024.03.15.585196 — neuroscience — Posted on 2024-04-24
1240 Involvement of TRPV4 in temperature-dependent perspiration in mice
Kashio, M.; Derouiche, S.; Yoshimoto, R. U.; Sano, K.; LEI, J.; Kido, M. A.; Tominaga, M.
10.1101/2023.10.25.563940 — physiology — Posted on 2024-04-24
1241 Ribosome Profiling Reveals Translational Reprogramming via mTOR Activation in Omacetaxine Resistant Multiple Myeloma
Walker, Z. J.; Vaeth, K. F.; Baldwin, A.; Ohlstrom, D. J.; Reiman, L. T.; Idler, B. M.; Stevens, B. M.; Mukherjee, N.; Sherbenou, D. W.
10.1101/2024.04.23.590843 — cancer biology — Posted on 2024-04-24
1245 Antimicrobial effects, and selection for AMR by non-antibiotic drugs on bacterial communities
Hayes, A.; Zhang, L.; Feil, E.; Kasprzyk-Hordern, B.; Snape, J.; Gaze, W. H.; Murray, A. K.
10.1101/2024.04.23.590690 — microbiology — Posted on 2024-04-23
1246 Identification of Glucosidase II that regulates STIM1 activation dynamics
Du, Y.; Zheng, S.; Wang, F.; Li, J.; Yuan, X.; Xi, C.; Wang, Y.; Zhou, Y.
10.1101/2024.04.20.590316 — cell biology — Posted on 2024-04-23
1249 Deep indel mutagenesis reveals the regulatory and modulatory architecture of alternative exon splicing
Baeza-Centurion, P.; Minana, B.; Faure, A.; Thompson, M.; Bonnal, S.; Quarantani, G.; Lehner, B.; Valcarcel, J.
10.1101/2024.04.21.590414 — genetics — Posted on 2024-04-23
1250 Time-resolved function of cell polarity kinases PRKCZ and PRKCI in CNS myelination
Mercau, M. E.; Hackbarth, R.-M.; Liu, X.; Wang, H.; Zhang, L.; Basu, M. K.; Rothlin, C. V.; Ghosh, S.
10.1101/2024.04.22.589759 — developmental biology — Posted on 2024-04-23
1252 Passage of the HIV capsid cracks the nuclear pore
Kreysing, J. P.; Heidari, M.; Zila, V.; Cruz-Leon, S.; Obarska-Kosinska, A.; Laketa, V.; Welsch, S.; Koefinger, J.; Turonova, B.; Hummer, G.; Kraeusslich, H.-G.; Beck, M.
10.1101/2024.04.23.590733 — biophysics — Posted on 2024-04-23
1253 Engineering of highly active and diverse nuclease enzymes by combining machine learning and ultra-high-throughput screening
Thomas, N.; Belanger, D.; Xu, C.; Lee, H.; Hirano, K.; Iwai, K.; Polic, V.; Nyberg, K. D.; Hoff, K.; Frenz, L.; Emrich, C. A.; Kim, J. W.; Chavarha, M.; Ramanan, A.; Agresti, J. J.; Colwell, L. J.
10.1101/2024.03.21.585615 — bioinformatics — Posted on 2024-04-23
1254 Sequence-to-sequence translation from mass spectra to peptides with a transformer model
Yilmaz, M.; Fondrie, W. E.; Bittremieux, W.; Melendez, C.; Nelson, R.; Ananth, V.; Oh, S.; Noble, W. S.
10.1101/2023.01.03.522621 — bioinformatics — Posted on 2024-04-23
1259 Biochemical Impact of p300-Mediated Acetylation of Replication Protein A: Implications for DNA Metabolic Pathway Choice
Ononye, O. E.; Surendran, S.; Howald, O. K.; Petrides, A. K.; Jordan, M. R.; Ainembabazi, D.; Wold, M. S.; Turchi, J. J.; Balakrishnan, L.
10.1101/2024.04.22.590612 — biochemistry — Posted on 2024-04-23
1261 A behavioral roadmap for the development of agency in the rodent
Mitelut, C.; Diez Castro, M.; Peterson, R. E.; Goncalves, M.; Li, J.; Gamer, M. M.; Nilsson, S. R. O.; Pereira, T. D.; Sanes, D. H.
10.1101/2023.11.10.566632 — animal behavior and cognition — Posted on 2024-04-23
1262 Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function
Gholamalamdari, O.; van Schaik, T.; Wang, Y.; Kumar, P.; Zhang, L.; Zhang, Y.; Gonzalez, G. A. H.; Vouzas, A. E.; Zhao, P. A.; Gilbert, D. M.; Ma, J.; van Steensel, B.; Belmont, A. S.
10.1101/2024.04.23.590809 — genomics — Posted on 2024-04-23
1264 Catalytically distinct IDH1 mutants tune phenotype severity in tumor models
Adam, M. A. A.; Robinson, M.; Schwartz, A. V.; Wells, G. A.; Hoang, A.; Albekioni, E.; Chao, G.; Weeks, J.; George, U. Z.; House, C. D.; Turcan, S.; Sohl, C. D.
10.1101/2024.04.22.590655 — genomics — Posted on 2024-04-23
1265 Confounding Fuels Hereditarian Fallacies
Benning, J. W.; Carlson, J.; Shaw, R.; Harpak, A. W.
10.1101/2023.11.01.565061 — genetics — Posted on 2024-04-23
1267 Intergenerational transport of double-stranded RNA limits heritable epigenetic changes
Shugarts, N.; Sathya, A.; Yi, A. L.; Chan, W. M.; Marre, J. A.; Jose, A. M.
10.1101/2021.10.05.463267 — genetics — Posted on 2024-04-23
1268 Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development
Yue, T.; Guo, Y.; Qi, X.; Zheng, W.; Zhang, H.; Wang, B.; Zhou, B.; Zeng, X.; NA, O.; He, Y.; Su, B.
10.1101/2023.05.24.542081 — evolutionary biology — Posted on 2024-04-23
1269 PBK/TOPK mediates Ikaros, Aiolos and CTCF displacement from mitotic chromosomes and alters chromatin accessibility at selected C2H2-zinc finger protein binding sites
Dimond, A.; Gim, D. H.; Ing-Simmons, E.; Whilding, C.; Kramer, H.; Djeghloul, D.; Montoya, A.; Patel, B.; Cheriyamkunnel, S.; Brown, K.; Shliaha, P.; Vaquerizas, J. M.; Merkenschlager, M.; Fisher, A. G.
10.1101/2024.04.23.590758 — molecular biology — Posted on 2024-04-23
1271 PRC2 Promotes Canalisation during Endodermal Differentiation
Hölzenspies, J. J.; Sengupta, D.; Bickmore, W. A.; Brickman, J. M.; Illingworth, R. S.
10.1101/2024.04.23.590736 — molecular biology — Posted on 2024-04-23
1274 Ribonuclease activity undermines immune sensing of naked extracellular RNA
Castellano, M.; Blanco, V.; Li Calzi, M.; Costa, B.; Witwer, K.; Hill, M.; Cayota, A.; Segovia, M.; Tosar, J. P.
10.1101/2024.04.23.590771 — molecular biology — Posted on 2024-04-23
1275 Regulation of Microprocessor assembly and localization via Pasha's WW domain in C. elegans
Montgomery, B. E.; Knittel, T. L.; Reed, K. J.; Chong, M. C.; Isolehto, I. J.; Cafferty, E. R.; Smith, M. J.; Sprister, R. A.; Magelky, C. N.; Scherman, H.; Ketting, R. F.; Montgomery, T. A.
10.1101/2024.04.23.590772 — molecular biology — Posted on 2024-04-23
1276 Systematic analysis of nonsense variants uncovers peptide release rate as a novel modifier of nonsense-mediated mRNA decay efficiency
Kolakada, D.; Fu, R.; Biziaev, N.; Shuvalov, A.; Lore, M.; Campbell, A. E.; Cortazar, M. A.; Sajek, M. P.; Hesselberth, J. R.; Mukherjee, N.; Alkalaeva, E.; Jagannathan, S.
10.1101/2024.01.10.575080 — molecular biology — Posted on 2024-04-23
1277 Dimalis: A complete standalone pipeline to analyse prokaryotic cell growth from time-lapse imaging
van der Meer, J. R.; Todorov, H.; Bentvelsen, B.; Ugolini, S.; Pacheco, A. R.; Convers, A.; Miguel Trabajo, T.
10.1101/2024.04.23.590675 — microbiology — Posted on 2024-04-23
1278 Mitochondrial ATP synthesis is essential for efficient gametogenesis in Plasmodium falciparum
Sparkes, P. C.; Famodimu, M. T.; Alves, E.; Springer, E.; Przyborski, J. M.; Delves, M. J.
10.1101/2024.04.23.590695 — microbiology — Posted on 2024-04-23
1280 Hackflex library preparation enables low-cost metagenomic profiling
Goldman, S. L.; Sanders, J. G.; Sprockett, D. D.; Landers, A.; Yan, W.; Moeller, A. H.
10.1101/2024.04.23.590092 — microbiology — Posted on 2024-04-23
1282 Production, analysis, and safety assessment of a soil and plant-based natural material with microbiome- and immune-modulatory effects
Parajuli, A.; Makela, I.; Roslund, M. I.; Ringqvist, E.; Manninen, J.; Sun, Y.; Nurminen, N.; Oikarinen, S.; Laitinen, O. H.; Hyoty, H.; Flodstrom-Tullberg, M.; Sinkkonen, A.
10.1101/2024.04.23.590687 — microbiology — Posted on 2024-04-23
1285 Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy
Lin, M.-H.; Maniam, P.; Li, D.; Tang, B.; Bishop, C.; Suhrbier, A.; Wales-Earl, L.; Tayyar, Y.; McMillan, N. A. J.; Li, L.; Harrich, D.
10.1101/2024.04.23.590664 — microbiology — Posted on 2024-04-23
1289 A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies
Liu, X.; Devadiga, S. A.; Stanley, R. F.; Moroow, R.; Janssen, K.; Quesnel-Vallieres, M.; Pomp, O.; Moverley, A. A.; Li, C.; Skuli, N.; Carroll, M. P.; Huang, J.; Wallace, D. C.; Lynch, K. W.; Abdel-Wahab, O.; Klein, P. S.
10.1101/2023.06.25.546449 — cancer biology — Posted on 2024-04-23
1290 UNSEG: unsupervised segmentation of cells and their nuclei in complex tissue samples
Kochetov, B.; Bell, P.; Garcia, P. S.; Shalaby, A. S.; Raphael, R.; Raymond, B.; Leibowitz, B. J.; Schoedel, K.; Brand, R. M.; Brand, R. E.; Yu, J.; Zhang, L.; Diergaarde, B.; Schoen, R. E.; Singhi, A.; Uttam, S.
10.1101/2023.11.13.566842 — bioinformatics — Posted on 2024-04-23
1296 Improved specificity and efficacy of base-editing therapies with hybrid guide RNAs
Whittaker, M. N.; Brooks, D. L.; Quigley, A.; Jindal, I.; Qu, P.; Wang, J. Z.; Ahrens-Nicklas, R. C.; Musunuru, K.; Alameh, M.-G.; Peranteau, W. H.; Wang, X.
10.1101/2024.04.22.590531 — molecular biology — Posted on 2024-04-23
1297 Cell-free assays reveal the HIV-1 capsid protects reverse transcripts from cGAS
Scott, T. M.; Arnold, L. M.; Powers, J. A.; McCann, D. A.; Christensen, D. E.; Zhou, W.; Torrez, R. M.; Iwasa, J. H.; Kranzusch, P. J.; Sundquist, W. I.; Johnson, J. S.
10.1101/2024.04.22.590513 — microbiology — Posted on 2024-04-23
1299 Deep, unbiased and quantitative mass spectrometry-based plasma proteome analysis of individual responses to mRNA COVID-19 vaccine
Huang, T.; Campos, A. R.; Wang, J.; Stukalov, A.; Diaz, R.; Maurya, S.; Motamedchaboki, K.; Hornburg, D.; Saciloto-de-Oliveira, L. R.; Innocente-Alves, C.; Calegari-Alves, Y. P.; Batzoglou, S.; Beys-da-Silva, W. O.; Santi, L.
10.1101/2024.04.22.589104 — immunology — Posted on 2024-04-23
1301 Mesolimbic dopamine ramps reflect environmental timescales
Floeder, J. R.; Jeong, H.; Mohebi, A.; K Namboodiri, V. M.
10.1101/2024.03.27.587103 — neuroscience — Posted on 2024-04-23
1302 Cell-type aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant Catharanthus roseus
Li, C.; Colinas, M.; Wood, J. C.; Vaillancourt, B.; Hamilton, J. P.; Jones, S. L.; Caputi, L.; O'Connor, S. E.; Buell, C. R.
10.1101/2024.04.23.590703 — plant biology — Posted on 2024-04-23
1303 Mechanism and spectrum of inhibition of a 4'-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses
Gordon, C. J.; Walker, S. M.; Tchesnokov, E. P.; Kocincova, D.; Pitts, J.; Siegel, D. S.; Perry, J. K.; Feng, J. Y.; Bilello, J. P.; Gotte, M.
10.1101/2024.04.22.590607 — biochemistry — Posted on 2024-04-23
1305 Essential conserved neuronal motors kinesin-1 and kinesin-3 regulate Abeta42 toxicity in vivo
Francis, D.; Paonessa, F.; Fabre, C. C. G.; Hewitt, V. L.; Giannakou, M. E.; Peset, I.; Whitworth, A. J.; Livesey, R.; Palacios, I. M.
10.1101/2024.04.23.590704 — cell biology — Posted on 2024-04-23
1307 Asymptomatic neonatal herpes simplex virus infection in mice leads to long-term cognitive impairment
Dutton, A. J.; Patel, C. D.; Taylor, S. A.; Garland, C. R.; Turnbaugh, E.; Alers-Velazquez, R.; Mehrbach, J.; Nautiyal, K. M.; Leib, D. A.
10.1101/2024.04.22.590596 — microbiology — Posted on 2024-04-23
1308 A single mutation G454A in P450 CYP9K1 drives pyrethroid resistance in the major malaria vector Anopheles funestus reducing bed net efficacy
Djoko Tagne, C. S.; Kouamo, M. F. M.; Tchouakui, M.; Muhammad, A.; Mugenzi, L. J. L.; Tatchou-Nebangwa, N. M. T.; Thiomela, R. F.; Gadji, M.; Wondji, M. J.; Hearn, J.; Desire, M. H.; Ibrahim, S. S.; Wondji, C. S.
10.1101/2024.04.22.590515 — genetics — Posted on 2024-04-23
1309 Reference genome of the ant Lasius platythorax
Feldmeyer, B.; Guiglielmoni, N.; Kirangwa, J.; Menzel, F.; Salces-Ortiz, J.; Fernandez, R.; Buena-Atienza, E.; Ciofi, C.; Diroma, M. A.; Iannucci, A.; Natali, C.; Mc Cartney, A.; Riess, O.; Casadei, N.; Waldvogel, A.-M.
10.1101/2023.07.18.549505 — genomics — Posted on 2024-04-23
1310 A general and efficient representation of ancestral recombination graphs
Wong, Y.; Ignatieva, A.; Koskela, J.; Gorjanc, G.; Wohns, A. W.; Kelleher, J.
10.1101/2023.11.03.565466 — genetics — Posted on 2024-04-23
1311 Improving genomic selection in hexaploid wheat with sub-genome additive and epistatic models
Tessele, A.; Gonzalez-Dieguez, D. O.; Crossa, J.; Johnson, B. E.; Morris, G. P.; Fritz, A. K.
10.1101/2024.04.19.590350 — genetics — Posted on 2024-04-23
1312 Combining environmental DNA and remote sensing for efficient, fine-scale mapping of arthropod biodiversity
Li, Y.; Devenish, C.; Tosa, M.; Luo, M.; Bell, D.; Lesmeister, D.; Greenfield, P.; Pichler, M.; Levi, T.; Yu, D. W.
10.1101/2023.09.07.556488 — ecology — Posted on 2024-04-23
1316 Redefining FLASH RT: the impact of mean dose rate and dose per pulse in the gastrointestinal tract
Liu, K.; Waldrop, T.; Aguilar, E.; Mims, N.; Neill, D.; Delahoussaye, A.; Li, Z.; Swanson, D.; Lin, S. H.; Koong, A. C.; Taniguchi, C. M.; Loo, B. W.; Mitra, D.; Schueler, E.
10.1101/2024.04.19.590158 — cancer biology — Posted on 2024-04-23
1317 A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor specificity
Synan, A.; Wu, N. C.; Velazquez, R.; Logel, C.; Mueller, K.; Green, A.; Barzaghi-Rinaudo, P.; Simmons, Q.; Mercan, S.; Shi, X.; Korn, J.; McLaughlin, M.; Tschantz, W. R.; Hainzl, D.; Malamas, A.; Cebe, R.; Xie, K. T.; D'Alessio, J. A.
10.1101/2024.04.19.590291 — cancer biology — Posted on 2024-04-23
1319 Unveiling the Mechanisms to Bypass KRAS Inhibition: In Vitro Insights into the Influence of Fibroblast-Secretome
Oliveira, S. M.; Carvalho, P. D.; Roma, A.; Oliveira, P.; Ribeiro, A.; Carvalho, J.; Martins, F.; Machado, A. L.; Oliveira, M. J.; Velho, S.
10.1101/2024.04.19.590324 — cancer biology — Posted on 2024-04-23
1320 BUB1 inhibition sensitizes lung cancer cell lines to radiotherapy and chemoradiotherapy
Thoidingjam, S.; Sriramulu, S.; Hassan, O.; Brown, S. L.; Siddiqui, F.; Movsas, B.; Gadgeel, S.; Nyati, S.
10.1101/2024.04.19.590355 — cancer biology — Posted on 2024-04-23
1321 Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer
Salas-Escabillas, D. J.; Hoffman, M. T.; Moore, J. S.; Brender, S. M.; Wen, H.-J.; Benitz, S.; Davis, E. T.; Long, D.; Wombwell, A. M.; Steele, N. G.; Sears, R. C.; Matsumoto, I.; DelGiorno, K. E.; Crawford, H. C.
10.1101/2024.02.12.579982 — cancer biology — Posted on 2024-04-23
1322 PUFA stabilizes a conductive state of the selectivity filter in IKs channels
Golluscio, A.; Eldstrom, J.; Jowais, J. J.; Perez, M. E.; Cunningham, K. P.; De La Cruz, A.; Wu, X.; Fedida, D.; Larsson, P.; Tieleman, D. P.; Corradi, V.
10.1101/2024.01.11.575247 — biophysics — Posted on 2024-04-23
1324 CYpHER: Catalytic extracellular targeted protein degradation with high potency and durable effect
Crook, Z. R.; Sevilla, G. P.; Young, P.; Girard, E. J.; Phi, T.-D.; Howard, M.; Price, J.; Olson, J. M.; Nairn, N. W.
10.1101/2024.02.21.581471 — bioengineering — Posted on 2024-04-23
1328 Genetic architecture of heritable leaf microbes
Boyle, J. A.; Frederickson, M. E.; Stinchcombe, J. R.
10.1101/2024.01.17.576069 — ecology — Posted on 2024-04-23
1330 Connecting Transcriptomics with Computational Modeling to Reveal Developmental Adaptations in the Human Pediatric Myocardium
Salameh, S.; Guerrelli, D.; Miller, J. A.; Desai, M.; Moise, N.; Yerebakan, C.; Bruce, A.; Sinha, P.; d'Udekem, Y.; Weinberg, S. H.; Posnack, N. G.
10.1101/2024.04.19.589826 — cell biology — Posted on 2024-04-23
1334 Antigen affinity and site of immunization dictate B cell recall responses
Termote, M.; Marques, R. C.; Hyllner, E.; Guryleva, M. V.; Henskens, M.; Brutscher, A.; Baken, I. J. L.; Castro Dopico, X.; Dalmau Gasull, A.; Murrell, B.; Stamatatos, L.; Westerberg, L. S.; Dosenovic, P.
10.1101/2024.04.19.590239 — immunology — Posted on 2024-04-23
1335 Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80 / PD-L1 interaction
Robinson, M. A.; Kennedy, A.; Orozco, C. T.; Chen, H.-C.; Waters, E. A.; Giovacchini, D.; Yeung, K.; Filer, L.; Hinze, C.; Lloyd, C.; Dovedi, S.; Sansom, D.
10.1101/2024.04.19.590271 — immunology — Posted on 2024-04-23
1337 Spinal cord injury: What are the lesion effects on transplanted cells in an autograft model?
Delarue, Q.; Brodier, M.; Neveu, P.; Moncomble, L.; Hugede, A.; Blondin, A.; Robac, A.; Raimond, C.; Lecras, P.; Riou, G.; Guerout, N.
10.1101/2024.04.19.590121 — neuroscience — Posted on 2024-04-23
1347 Changes in intra- and interlimb reflexes from forelimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats
Mari, S.; Lecomte, C. G.; Merlet, A. N.; Audet, J.; Yassine, S.; Al Arab, R.; Harnie, J.; Rybak, I. A.; Prilutsky, B.; Frigon, A.
10.1101/2024.04.23.590723 — neuroscience — Posted on 2024-04-23
1349 Quantitative single cell mass spectrometry reveals the dynamics of plant natural product biosynthesis
Vu, A. H.; Kang, M.; Wurlitzer, J.; Heinicke, S.; Li, C.; Wood, J. C.; Grabe, V.; Buell, C. R.; Caputi, L.; O'Connor, S. E.
10.1101/2024.04.23.590720 — biochemistry — Posted on 2024-04-23
1350 Characterization of novel and essential kinetoplast-associated proteins in Trypanosoma brucei
Cadena, L. R.; Svobodova, M.; Benz, C.; Raskova, V.; Chmelova, L.; Skodova-Sverakova, I.; Yurchenko, V.; Lukes, J.; Hammond, M.; Durante, I. M.
10.1101/2024.04.22.590512 — cell biology — Posted on 2024-04-23
1353 Enhanced behavioural and neural sensitivity to punishments in chronic pain and fatigue
Mancini, F.; Mahajan, P.; Guttesen, A. a. V.; Onysk, J.; Scholtes, I.; Shenker, N.; Lee, M.; Seymour, B.
10.1101/2024.04.04.588151 — neuroscience — Posted on 2024-04-23
1354 Sexual dimorphism in the tardigrade Paramacrobiotus metropolitanus transcriptome
Sugiura, K.; Yoshida, Y.; Hayashi, K.; Arakawa, K.; Kunieda, T.; Matsumoto, M.
10.1101/2024.04.19.590226 — zoology — Posted on 2024-04-23
1355 Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females.
Patton, M. E.; Kelekar, S.; Taylor, L. J.; Dean, A. E.; Zuo, Q.; Thakare, R. N.; Lee, S. H.; Gentry, E.; Panitchpakdi, M.; Dorrestein, P.; Alnouti, Y.; Madak-Erdogan, Z.; Lee, J.-S.; Finegold, M. J.; Anakk, S.
10.1101/2020.06.25.172635 — cancer biology — Posted on 2024-04-23
1356 Internal unwinding mechanism of a replicative helicase
Shahid, T.; Tehseen, M.; Alhudhali, L.; Clark, A. R.; Savva, C. G.; Hamdan, S. M.; De Biasio, A.
10.1101/2024.04.19.590217 — biophysics — Posted on 2024-04-23
1360 Distractor suppression operates exclusively in retinotopic coordinates
Ilksoy, Y. A.; van Moorselaar, D.; Wang, B.; Los, S. A.; Theeuwes, J.
10.1101/2024.02.01.578407 — neuroscience — Posted on 2024-04-23
1363 Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling
Zoltowska, K. M.; Das, U.; Lismont, S.; Enzlein, T.; Maesako, M.; Houser, M. C.; Gomes Moreira, D.; Franco, M. L.; Ozcan, B.; Karachentsev, D.; Becker, A.; Hopf, C.; Vilar, M.; Berezovska, O.; Mobley, W.; Chavez-Gutierrez, L.
10.1101/2023.08.02.551596 — biochemistry — Posted on 2024-04-23
1364 Bacterial exonuclease III expands its enzymatic activities on single-stranded DNA
Wang, H.; Ye, C.; Lu, Q.; Jiang, Z.; Jiang, C.; Zhou, C.; Li, N.; Zhang, C.; Zhao, G.; Yue, M.; Li, Y.
10.1101/2024.01.13.575533 — biochemistry — Posted on 2024-04-23
1366 A scalable CRISPR-Cas9 gene editing system facilitates CRISPR screens in the malaria parasite Plasmodium berghei
Jonsdottir, T. K.; Paoletta, M. S.; Ishizaki, T.; Hernandez, S.; Ivanova, M.; Herrera Curbelo, A.; Saiki, P. A.; Selinger, M.; Das, D.; Henriksson, J.; Bushell, E. S.
10.1101/2024.04.20.590404 — molecular biology — Posted on 2024-04-23
1367 A neurometabolic signature in the frontal cortex explains individual differences in effort-based decision-making
Barakat, A.; Clairis, N.; Brochard, J.; Pessiglione, M.; Godin, J.-P.; Cuenoud, B.; Xin, L.; Sandi, C.
10.1101/2024.01.23.576854 — neuroscience — Posted on 2024-04-23
1370 Delta-5 elongase knockout reduces DHA and TAG synthesis coupled with an increase of heat sensitivity in a marine diatom
Zhu, J.; Li, S.; Chen, W.; Xu, X.; Wang, X.; Wang, X.; Han, J.; Jouhet, J.; Amato, A.; Marechal, E.; Hu, H.; Allen, A. E.; Gong, Y.; Jiang, H.
10.1101/2024.04.19.590303 — plant biology — Posted on 2024-04-23
1371 Seed coat formation in Arabidopsis requires a concerted action of JUMONJI histone H3K27me3 demethylases and Brassinosteroid signaling
Pankaj, R.; Lima, R. B.; Luo, G.-Y.; Ehlert, S.; Del Toro-De Leon, G.; Bente, H.; Finger, P.; Sato, H.; Figueiredo, D. D.
10.1101/2023.12.07.569203 — plant biology — Posted on 2024-04-23
1372 ATG8ylation of vacuolar membrane protects plants against cell wall damage
Julian, J.; Gao, P.; Del Chiaro, A.; De La Concepcion, J. C.; Armengot, L.; Somssich, M.; Duverge, H.; Clavel, M.; Grujic, N.; Kobylinska, R.; Polivka, I.; Besten, M.; Dank, C.; Korbei, B.; Bachmair, A.; Coll, N. S.; Sprakel, J.; Dagdas, Y.
10.1101/2024.04.21.590262 — plant biology — Posted on 2024-04-23
1376 Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression
Yamamoto, T.; Nakayama, J.; Urabe, F.; Ito, K.; NIshida-Aoki, N.; Kitagawa, M.; Yokoi, A.; Kuroda, M.; Hattori, Y.; Yamamoto, Y.; Ochiya, T.
10.1101/2022.05.10.491299 — cancer biology — Posted on 2024-04-23
1377 Massively parallel reporter assays and mouse transgenic assays provide complementary information about neuronal enhancer activity
Kosicki, M.; Cintron, D. L.; Page, N. F.; Georgakopoulos-Soares, I.; Akiyama, J. A.; Plajzer-Frick, I.; Novak, C. S.; Kato, M.; Hunter, R. D.; von Maydell, K.; Barton, S.; Godfrey, P.; Beckman, E.; Sanders, S. J.; Pennacchio, L. A.; Ahituv, N.
10.1101/2024.04.22.590634 — genomics — Posted on 2024-04-23
1378 Food entrainment in mice leads to sex- and organ-specific responses in the digestive system and nutrient metabolism
Oparija-Rogenmozere, L.; Di Natale, M. R.; Hunne, B. L.; Koo, A.; Ringuet, M.; Fazio Coles, T. E.; Fothergill, L.; McQuade, R.; Furness, J. B.
10.1101/2024.02.20.580958 — molecular biology — Posted on 2024-04-23
1379 Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors
Ozkan, A.; Padmanabhan, H. K.; Shipman, S.; Azim, E.; Kumar, P.; Sadegh, C.; Basak, N.; Macklis, J. D.
10.1101/2024.04.21.590488 — neuroscience — Posted on 2024-04-23
1382 Infraslow dynamic patterns in human cortical networks track a spectrum of external to internal attention
Watters, H.; Davis, A.; Fazili, A.; Daley, L.; LaGrow, T. J.; Schumacher, E. H.; Keilholz, S.
10.1101/2024.04.22.590625 — neuroscience — Posted on 2024-04-23
1383 Sex differences in the functional network underpinnings of psychotic-like experiences in children
Dhamala, E.; Chopra, S.; Ooi, L. Q. R.; Rubio, J. M.; Yeo, B. T. T.; Malhotra, A. K.; Holmes, A. J.
10.1101/2024.04.22.590660 — neuroscience — Posted on 2024-04-23
1384 Perpetual step-like restructuring of hippocampal circuit dynamics
Zheng, Z.; Huszar, R.; Hainmueller, T.; Bartos, M.; Williams, A.; Buzsaki, G.
10.1101/2024.04.22.590576 — neuroscience — Posted on 2024-04-23
1385 GABA/Glutamate neuron differentiation imbalance and increased AKT/mTOR signalling in CNTNAP2-/-cerebral organoids.
Chalkiadaki, K.; Statoulla, E.; Zafeiri, M.; Voudouri, G.; Typou, A.; Amvrosiadis, T.; Theodoridou, N.; Moschovas, D.; Avgeropoulos, A.; Samiotaki, M.; Mason, J. O.; Gkogkas, C. G.
10.1101/2024.04.21.590378 — neuroscience — Posted on 2024-04-23
1387 Blocking uncertain errors of PCR
Takahashi, T.; Aoyanagi, H.; Pigolotti, S.; Toyabe, S.
10.1101/2024.04.19.590219 — bioengineering — Posted on 2024-04-23
1390 A new series of fluorogen-activating proteins for quantitative protein trafficking and co-localization studies in S. cerevisiae
Oppenheimer, K. G.; Hager, N. A.; McAtee, C. K.; Filiztekin, E.; Shang, C.; Warnick, J. A.; Bruchez, M. P.; Brodsky, J. L.; Prosser, D. C.; Kwiatkowski, A. V.; O'Donnell, A. F.
10.1101/2024.04.20.590399 — cell biology — Posted on 2024-04-22
1391 Dose-Efficient Cryo-Electron Microscopy for Thick Samples using Tilt-Corrected Scanning Transmission Electron Microscopy, Demonstrated on Cells and Single Particles
Yu, Y.; Spoth, K. A.; Colletta, M.; Nguyen, K. X.; Zeltmann, S. E.; Zhang, X. S.; Paraan, M.; Kopylov, M.; Dubbeldam, C.; Serwas, D.; Siems, H.; Muller, D. A.; Kourkoutis, L. F.
10.1101/2024.04.22.590491 — cell biology — Posted on 2024-04-22
1393 Epiregulon: Inference of single-cell transcription factor activity to dissect mechanisms of lineage plasticity and drug response
Wlodarczyk, T.; Lun, A.; Wu, D.; Menon, S.; Toneyan, S.; Seidel, K.; Wang, L.; Tan, J.; Chen, S.-Y.; Keyes, T.; Chlebowski, A.; Guo, Y.; Metcalfe, C.; Hafner, M.; Siebel, C. W.; Corces, M. R.; Yauch, R.; Xie, S.; Yao, X.
10.1101/2023.11.27.568955 — bioinformatics — Posted on 2024-04-22
1394 Single-molecule visualization of sequence-specific RNA binding by a designer PPR protein
Marzano, N. R.; Johnston, B.; Paudel, B. P.; Schmidberger, J.; Jergic, S.; Bocking, T.; Agostino, M.; Small, I.; van Oijen, A. M.; Bond, C. S.
10.1101/2024.04.22.590477 — biochemistry — Posted on 2024-04-22
1396 Macrophages allocate independent of apoptosis and produce reactive oxygen species during interdigital phagocytosis
Hernandez-Garcia, D.; Garcia-Melendrez, C.; Hernandez-Martinez, R.; Collazo-Navarrete, O.; Covarrubias, L.
10.1101/2023.05.04.539494 — developmental biology — Posted on 2024-04-22
1397 Improved specificity and efficacy of base-editing therapies with hybrid guide RNAs
Whittaker, M. N.; Brooks, D. L.; Quigley, A.; Jain, I.; Qu, P.; Wang, J. Z.; Ahrens-Nicklas, R. C.; Musunuru, K.; Alameh, M.-G.; Peranteau, W. H.; Wang, X.
10.1101/2024.04.22.590531 — molecular biology — Posted on 2024-04-22
1399 Cell-free reconstitution of HIV-1 innate immune sensing reveals the capsid is a molecular cloak that protects reverse transcripts from cGAS
Scott, T. M.; Arnold, L. M.; Powers, J. A.; McCann, D. A.; Christensen, D. E.; Zhou, W.; Torrez, R. M.; Iwasa, J. H.; Kranzusch, P. J.; Sundquist, W. I.; Johnson, J. S.
10.1101/2024.04.22.590513 — microbiology — Posted on 2024-04-22
1400 Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides
Lee, K. K.; Lapinska, U.; Tolle, G.; Phetsang, W.; Verderosa, A.; Invergo, B. M.; Westley, J.; Bebes, A.; Yuecel, R.; ONeill, P. A.; Farbos, A.; Jeffries, A. R.; van Houte, S.; Caboni, P.; Blaskovich, M.; Housden, B.; Tsaneva-Atanasova, K.; Pagliara, S.
10.1101/2024.04.22.590445 — microbiology — Posted on 2024-04-22
1401 Molecular architecture of glideosome and nuclear F-actin in Plasmodium falciparum
Prazak, V.; Vasishtan, D.; Grunewald, K.; Douglas, R. G.; Ferreira, J. L.
10.1101/2024.04.22.590301 — microbiology — Posted on 2024-04-22
1403 The role of endospore appendages in spore-spore contacts in pathogenic bacilli
Jonsmoen, U. L.; Malyshev, D.; Sleutel, M.; Kristensen, E. E.; Zegeye, E. D.; Remaut, H.; Andersson, M.; Aspholm, M. E.
10.1101/2024.04.22.590507 — microbiology — Posted on 2024-04-22
1407 Synthetic bacteria with programmed cell targeting and protein injection suppress tumor growth in vivo
Asensio-Calavia, A.; Manas, C.; Cabrera-Fisac, A.; Pico-Sanchez, E.; Seco, E. M.; Kolodziej, S.; Leventhal, D. S.; Lora, J.; Alvarez, B.; Fernandez, L. A.
10.1101/2024.04.22.590337 — synthetic biology — Posted on 2024-04-22
1408 Nationwide Inclusive Facilitator Training: Mindsets, Practices and Growth
Codding, D.; Yen, A. H.; Lewis, H.; Johnson-Ojeda, V.; Frey, R. F.; Hokanson, S. C.; Goldberg, B. B.
10.1101/2024.01.08.574770 — scientific communication and education — Posted on 2024-04-22
1409 Key role of down-regulated in adenoma (SLC26A3) chloride/bicarbonate exchanger in linaclotide-stimulated intestinal bicarbonate secretion upon loss of CFTR function
Sarthi, J. B.; Trumbull, A. M.; Abazari, S. M.; van Unen, V.; Chan, J. E.; Jiang, Y.; Gammons, J.; Andrerson, M. O.; Cil, O.; Kuo, C.; Sellers, Z. M.
10.1101/2023.05.05.539132 — physiology — Posted on 2024-04-22
1410 Cancer Prevalence Across Vertebrates
Compton, Z. T.; Mellon, W.; Harris, V.; Rupp, S.; Mallo, D.; Kapsetaki, S.; Wilmot, M.; Kennington, R.; Noble, K.; Baciu, C.; Ramirez, L.; Peraza, A.; Martins, B.; Sudhakar, S.; Aksoy, S.; Furukawa, G.; Vincze, O.; Giraudeau, M. T.; Duke, E.; Spiro, S.; Flach, E.; Davidson, H.; Li, C.; Zehnder, A.; Graham, T. A.; Troan, B.; Harrison, T.; Tollis, M.; Schiffman, J.; Aktipis, A.; Abegglen, L.; Maley, C.; Boddy, A.
10.1101/2023.02.15.527881 — cancer biology — Posted on 2024-04-22
1412 Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery
Liang, X.; Gupta, D.; Xie, J.; Wonterghem, E. V.; Hoecke, L. V.; Hean, J.; Niu, Z.; Wiklander, O. P. B.; Zheng, W.; Wiklander, R. J.; He, R.; Mamand, D. R.; Bost, J.; Zhou, G.; Zhou, H.; Roudi, S.; Zickler, A. M.; Gorgens, A.; Hagey, D.; de Jong, O. G.; Uy, A. G.; Zong, Y.; Mager, I.; Perez, C. M.; Roberts, T. C.; Vader, P.; Fougerolles, A. d.; Wood, M. J. A.; Vandenbroucke, R. E.; Nordin, J. Z.; EL Andaloussi, S.
10.1101/2023.04.30.535834 — bioengineering — Posted on 2024-04-22
1414 SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain
Chandrasekaran, T. T.; Choudalakis, M.; Broehm, A.; Weirich, S.; Kouroukli, A. G.; Ammerpohl, O.; Rathert, P.; Bashtrykov, P.; Jeltsch, A.
10.1101/2024.04.22.590554 — biochemistry — Posted on 2024-04-22
1415 A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity
Xia, J.; Siffert, A.; Torres, O.; Banasiak, J.; Pakula, K.; Ziegler, J.; Rosahl, S.; Ferro, N.; Jasinski, M.; Hegedus, T.; Geisler, M.
10.1101/2024.04.22.590559 — biochemistry — Posted on 2024-04-22
1416 Natural compound screening predicts novel GSK-3 isoform-specific inhibitors
Ahmad, F.; Gupta, A.; Marzook, H.; Woodgett, J. R.; Saleh, M. A.; Qaisar, R.
10.1101/2024.04.22.590490 — biochemistry — Posted on 2024-04-22
1417 Home security cameras as a tool for behavior observations and science affordability
Goolsby, B. C.; Fischer, M.-T.; Chen, T. G.; Pareja-Mejia, D.; Shaykevich, D. A.; Lewis, A. R.; Raboisson, G.; Lacey, M. P.; O'Connell, L. A.
10.1101/2023.04.17.537238 — animal behavior and cognition — Posted on 2024-04-22
1418 Optical genome mapping enables accurate repeat expansion testing
van der Sanden, B.; Neveling, K.; Shukor, S.; Gallagher, M. D.; Lee, J.; Burke, S. L.; Pennings, M.; van Beek, R.; Oorsprong, M.; Kater-Baats, E.; Kamping, E.; Tieleman, A.; Voermans, N.; Scheffer, I. E.; Gecz, J.; Corbett, M.; Vissers, L. E.; Pang, A. W.; Hastie, A.; Kamsteeg, E.-J.; Hoischen, A.
10.1101/2024.04.19.590273 — genomics — Posted on 2024-04-22
1419 Role of m6A RNA methylation in dosage compensation
Naik, H. C.; Baro, R.; Sarkar, A.; M, M. N.; Sunagar, K.; GAYEN, S.
10.1101/2024.04.22.590572 — genetics — Posted on 2024-04-22
1420 A Transcriptomic Hourglass In Brown Algae
Lotharukpong, J. S.; Zheng, M.; Luthringer, R.; Haas, F. B.; Drost, H.-G.; Coelho, S. M.
10.1101/2024.04.20.590401 — evolutionary biology — Posted on 2024-04-22
1423 Structural basis for the inhibition of coronaviral main proteases by PF-00835231
Zhou, X.; Lu, X.; Lin, C.; Zou, X.; Li, W.; Zeng, X.; Wang, J.; Zeng, P.; Wang, W.; Zhang, J.; Jiang, H.; Li, J.
10.1101/2024.04.22.590578 — molecular biology — Posted on 2024-04-22
1426 Antiviral and Antibacterial Efficacy of Nanocomposite Amorphous Carbon Films with Copper Nanoparticles
Bakhet, S.; Tamuleviciene, A.; Vasiliauskas, A.; Andrulevicius, M.; Meskinis, S.; Tamulevicius, S.; Kasetiene, N.; Malakauskas, M.; Lelesius, R.; Zienius, D.; Salomskas, A.; Smits, K.; Tamulevicius, T.
10.1101/2023.10.13.562202 — microbiology — Posted on 2024-04-22
1432 The gatekeeper to gastric cancer; gastric microbiota invade the lamina propria in Helicobacter pylori-associated gastric carcinogenesis
Giddings, H. J.; Teodosio, A.; McMurray, J. L.; Hunter, K.; Abdawn, Z.; Cole, J. A.; Shannon-Lowe, C. D.; Rossiter-Pearson, A. E.
10.1101/2024.04.22.590522 — microbiology — Posted on 2024-04-22
1433 Deep sequencing of 16 Ixodes ricinus ticks unveils insights into their interactions with endosymbionts.
Lesiczka, P. M.; Azagi, T.; Krawczyk, A. I.; Scott, W. T.; Dirks, R. P.; Simo, L.; Dobler, G.; Nijsse, B.; Schaap, P. J.; Sprong, H.; Koehorst, J. J.
10.1101/2024.04.22.590557 — microbiology — Posted on 2024-04-22
1435 Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity
Carmi, Y.; Farhat-Younis, L.; Na, M.; Zarfin, A.; Santana-Magal, N.; Richter, A.; Khateeb, A.; Gutwillig, A.; Rasoulouniriana, D.; Gleiberman, A.; Beck, L.; Giger, T.; Ashkenazi, A.; Barzel, A.; Rider, P.
10.1101/2023.09.30.560338 — immunology — Posted on 2024-04-22
1436 Humoral immunogenicity comparison of XBB and JN.1 in human infections
Jian, F.; Yisimayi, A.; Song, W.; Wang, J.; Xu, Y.; Chen, X.; Yu, Y.; Niu, X.; Yang, S.; Wang, P.; Sun, H.; Yu, L.; Wang, J.; Wang, Y.; An, R.; Wang, W.; Xiao, T.; Gu, Q.; Shao, F.; Wang, Y.; Shen, Z.; Jin, R.; Cao, Y.
10.1101/2024.04.19.590276 — immunology — Posted on 2024-04-22
1439 REM disruption and REM Vagal Activity Predict Extinction Recall in Trauma-Exposed Individuals
Yuksel, C.; Watford, L.; Muranaka, M.; McCoy, E. C.; Lax, H.; Mendelsohn, A. K.; Oliver, K. I.; Daffre, C.; Acosta, A.; Vidrin, A.; Martinez, U.; Lasko, N.; Orr, S.; Pace-Schott, E. F.
10.1101/2023.09.28.560007 — neuroscience — Posted on 2024-04-22
1440 Trait Reward Sensitivity Modulates Connectivity with the Temporoparietal Junction and Anterior Insula during Strategic Decision Making
Sazhin, D.; Wyngaarden, J. B.; Dennison, J. B.; Zaff, O.; Fareri, D.; McCloskey, M. S.; Alloy, L. B.; Jarcho, J. M.; Smith, D. V.
10.1101/2023.10.19.563125 — neuroscience — Posted on 2024-04-22
1442 Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Vlachavas, E. I.; Voutetakis, K.; Kosmidou, V.; Tsikalakis, S.; Roditis, S.; Pateas, K.; Kim, R.; Pagel, K.; Wolf, S.; Warsow, G.; Dimitrakopoulou-Strauss, A.; Zografos, G. N.; Pintzas, A.; Betge, J.; Papadodima, O.; Wiemann, S.
10.1101/2024.04.17.589725 — cancer biology — Posted on 2024-04-22
1443 GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior
Bhat, A. M.; Mohapatra, B. C.; Luan, H.; Mushtaq, I.; Chakraborty, S.; Kumar, S.; Wu, W.; Nolan, B.; Dutta, S.; Stock, M. D.; Schott, M.; Meza, J. L.; Lele, S. M.; Lin, M.-F.; Cook, L. M.; Corey, E.; Morrissey, C.; Coulter, D. W.; Rowley, J.; Natarajan, A.; Datta, K.; Band, V.; Band, H.
10.1101/2023.03.18.533299 — cancer biology — Posted on 2024-04-22
1444 An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs.
Chapple, R. H.; Liu, X.; Natarajan, S.; Alexander, M. I. M.; Kim, Y.; Patel, A. G.; LaFlamme, C. W.; Pan, M.; Wright, W. C.; Lee, H.-M.; Zhang, Y.; Lu, M.; Koo, S. C.; Long, C.; Harper, J.; Savage, C.; Johnson, M. D.; Confer, T.; Akers, W. J.; Dyer, M. A.; Sheppard, H.; Easton, J.; Geeleher, P.
10.1101/2023.04.13.536639 — cancer biology — Posted on 2024-04-22
1448 Transformer-based deep learning integrates multi-omic data with cancer pathways
Cai, Z.; Poulos, R. C.; Aref, A.; Robinson, P. J.; Reddel, R. R.; Zhong, Q.
10.1101/2022.10.27.514141 — bioinformatics — Posted on 2024-04-22
1452 Forage conservation is a neglected nitrous oxide source
Yang, S.; Mahmood, M.; Baral, R.; Wu, H.; Almloff, M.; Stanton, L.; Min, D.; Smiley, B.; Liams, C.; Yu, J.; Im, J.
10.1101/2024.03.19.585631 — bioengineering — Posted on 2024-04-22
1453 The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress
Holfelder, P.; Hensen, L.; Prentzell, M. T.; Razquin Navas, P.; Solvay, M.; Sadik, A.; Sayeeram, D.; Rehbein, U.; Bausbacher, T.; Egger, A.-S.; Regin, L.; Heberle, A. M.; Seifert, S.; Leytens, A.; Kowar, A.; Waltl, L.; Gollowitzer, A.; Kataura, T.; Ouhadi, S.; Karabogdan, I.; Hotze, M.; Kipura, T.; van Pijkeren, A.; Zhang, Y.; Rodriguez Peiris, M.; Barile, C.; Zhu, J.; Timpen, L. E.; Hatzmann, F.; Reintjes, A.; Berdel, B.; Somarribas Patterson, L. F.; Reil, M.; Peters, V.; Ramos Pittol, J.; van t Land-Kuper, I.; Eckhardt, L. E.; Sievers, P.; Sahm, F.; Mohammed, S. A.; Bording, T.; Harder, S.;
10.1101/2023.01.16.523931 — biochemistry — Posted on 2024-04-22
1454 Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes.
Qadir, M. M. F.; Elgamal, R. M.; Song, K.; Kudtarkar, P.; Sakamuri, S. S. V. P.; Katakam, P. V.; El-Dahr, S.; Kolls, J. K.; Gaulton, K. J.; Mauvais-Jarvis, F.
10.1101/2024.04.11.589096 — genomics — Posted on 2024-04-22
1455 Cytosolic Ribosomal Protein Haploinsufficiency affects Mitochondrial Morphology and Respiration
Surya, A.; Bolton, B. M.; Rothe, R.; Mejia-Trujillo, R.; Zhao, Q.; Leonita, A.; Liu, Y.; Rangan, R.; Gorusu, Y.; Nguyen, P.; Cenik, C.; Sarinay Cenik, E.
10.1101/2024.04.16.589775 — genetics — Posted on 2024-04-22
1458 Worldwide soundscape ecology patterns across realms
Darras, K. F.; Rountree, R.; Van Wilgenburg, S.; Dong, L.; Gasc, A.; Pitz, F.; Chen, Y.; Lin, T.-H.; Diaz, P. M.; Wu, S.-H.; Salton, M.; Marley, S.; Cord, A. F.; Acevedo-Charry, O.; Adam, M.; Aparecido Do Nascimento, L.; Astaras, C.; Atemasov, A.; Barbaro, L.; Batist, C.; Baucells, A. L.; Bayle Sempere, J. T.; Bellisario, K.; Ben David, A.; Berger-Tal, O.; Betts, M.; Bhalla, I.; Bicudo, T.; Bolgan, M.; Bombaci, S.; Boullhesen, M.; Bradfer-Lawrence, T.; Briers, R. A.; Budka, M.; Calvente, A.; Cerezo-Araujo, M.; Cerwen, G.; Desjonqueres, C.; Diniz, P.; Duarte, A.; Enari, H.; Enari, H. S.; Ferrar
10.1101/2024.04.10.588860 — ecology — Posted on 2024-04-22
1459 Why models underestimate West African tropical forest productivity
zhang-zheng, h.; Deng, X.; Stocker, B.; Ruijie, R.; Thomson, E.; Adu-Bredu, S.; Duah-Gyamfi, A.; Gvozdevaite, A.; Moore, S.; Oliveras Menor, I.; Prentice, I. C.; Malhi, Y.
10.1101/2024.03.08.584066 — ecology — Posted on 2024-04-22
1460 Cardiopulmonary bypass activates classical monocytes via shear-mediated activation of Store-Operated Calcium Entry
Li, W.; Tu, L. N.; Hsieh, L.; Smith, J. R.; Yeh, Y.-T.; Sinyagin, A.; Ghassemian, M.; Timms, A.; Charette, K.; Mauchley, D.; McMullan, M.; Bohuta, L.; Greene, C.; Regier, M.; del Alamo, J. C.; Savan, R.; Nigam, V.
10.1101/2022.05.04.490549 — cell biology — Posted on 2024-04-22
1461 Air monitoring by nanopore sequencing
Reska, T.; Pozdniakova, S.; Borras, S.; Schloter, M.; Canas, L.; Perlas, A.; Rodo, X.; Winkler, B.; Schnitzler, J.-P.; Urban, L.
10.1101/2023.12.19.572325 — molecular biology — Posted on 2024-04-22
1462 Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response
Lingegowda, H.; Zutautas, K. B.; Wei, Y.; Yolmo, P.; Sisnett, D. J.; McCallion, A.; Koti, M.; Tayade, C.
10.1101/2023.10.11.561929 — immunology — Posted on 2024-04-22
1463 IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission
Prakash, A.; Fenner, F.; Shit, B.; Salminen, T. S.; Monteith, K. M.; Khan, I.; Vale, P. F.
10.1101/2023.02.22.529244 — immunology — Posted on 2024-04-22
1469 Droplet Hi-C for Fast and Scalable Profiling of Chromatin Architecture in Single Cells
Chang, L.; Xie, Y.; Taylor, B.; Wang, Z.; Sun, J.; Tan, T. R.; Bejar, R.; Chen, C. C.; Furnari, F. B.; Hu, M.; Ren, B.
10.1101/2024.04.18.590148 — genomics — Posted on 2024-04-22
1474 Cerebrospinal fluid proteome profiling using machine learning shows a unique protein signature associated with APOE4 genotype
Shvetcov, A.; Thomson, S.; Cho, A.-N.; Wilkins, H. M.; Reed, J. H.; Swerdlow, R. H.; Brown, D. A.; Alzheimer's Disease Neuroimaging Initiative, ; Finney, C. A.
10.1101/2024.04.18.590160 — neuroscience — Posted on 2024-04-22
1476 The geometry of prey capture in praying mantis forelegs
Dan, S. D.; Taylor, D. S.; Yockey, J.; Svenson, G. J.; Martin, J. P.
10.1101/2024.04.18.590067 — zoology — Posted on 2024-04-22
1477 Colonial Architecture Modulates the Speed and Efficiency of Multi-Jet Swimming in Salp Colonies
Damian-Serrano, A.; Walton, K. A.; Bishop-Perdue, A.; Bagoye, S.; Du Clos, K. T.; Gemmell, B. J.; Colin, S. P.; Costello, J. H.; Sutherland, K. R.
10.1101/2024.04.18.590155 — zoology — Posted on 2024-04-22
1478 Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequences
Ruffolo, J. A.; Nayfach, S.; Gallagher, J.; Bhatnagar, A.; Beazer, J.; Hussain, R.; Russ, J.; Yip, J.; Hill, E.; Pacesa, M.; Meeske, A. J.; Cameron, P.; Madani, A.
10.1101/2024.04.22.590591 — synthetic biology — Posted on 2024-04-22
1487 VRN2-PRC2 facilitates light-triggered repression of PIF signalling to coordinate growth in Arabidopsis
Osborne, R.; Labandera, A.-M.; Ryder, A. J.; Kanali, A.; Akintewe, O.; Schwarze, M. A.; Morgan, C. D.; Xu, T.; Hartman, S.; Kaiserli, E.; Gibbs, D. J.
10.1101/2024.04.22.590552 — plant biology — Posted on 2024-04-22
1490 Spatial Transcriptomics in Mechanomics: New Horizons in Exploring the Mechanoregulation of Bone Regeneration
Mathavan, N.; Singh, A.; Correia Marques, F.; Günther, D.; Kuhn, G.; Wehrle, E.; Müller, R.
10.1101/2024.04.18.590091 — physiology — Posted on 2024-04-22
1491 Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice
Matta, L.; Weber, P.; Erener, S.; Walth-Hummel, A.; Hass, D.; Buehler, L. K.; Klepac, K.; Szendroedi, J.; Guerra, J.; Rohm, M.; Sterr, M.; Lickert, H.; Bartelt, A.; Herzig, S.
10.1101/2024.04.18.590140 — physiology — Posted on 2024-04-22
1492 ITGB6 inhibition stimulates anti-tumor responses in immunocompetent mouse models of head & neck squamous cell carcinoma and pancreatic adenocarcinoma
MacDonald, W. J.; Srinivasan, P. R.; Pinho-Schwermann, M.; Zhang, S.; Tajiknia, V.; Purcell, C.; Strandberg, J.; El-Deiry, W. S.
10.1101/2024.04.18.590156 — cancer biology — Posted on 2024-04-22
1495 Local cryptic diversity in salinity adaptation mechanisms in a wild outcrossing Brassica
Busoms, S.; da Silva, A.; Escola, G.; Abdilzadeh, R.; Curran, E.; Bollmann-Giolai, A.; Bray, S.; Wilson, M.; Poschenrieder, C.; Yant, L.
10.1101/2024.04.18.590122 — evolutionary biology — Posted on 2024-04-22
1499 Nrf2 regulates the activation-driven expansion of CD4+ T-cells by differentially modulating glucose and glutamine metabolism
Tripathi, A.; Dasgupta, D.; Pant, A.; Bugbee, A.; Yellapu, N. K.; Choi, B. H. Y.; Giri, s.; Pyaram, K.
10.1101/2024.04.18.590146 — immunology — Posted on 2024-04-22
1500 Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia
Barneh, F.; Koedijk, J. B.; Wijnen, N. E.; Meulendijks, T.; Ashtiani, M.; Dunnebach, E.; Dautzenberg, N.; Cornel, A. M.; Krippner-Heidenreich, A.; Klein, K.; Zwaan, C. M.; Kuball, J.; Nierkens, S.; Cloos, J.; Kaspers, G. J. L.; Heidenreich, O.
10.1101/2024.04.19.590200 — immunology — Posted on 2024-04-22
1501 Neural correlates of pure presence
Boly, M.; Smith, R.; Vigueras Borrego, G.; Pozuelos, J. P.; Allaudin, T.; Malinowski, P.; Tononi, G.
10.1101/2024.04.18.590081 — neuroscience — Posted on 2024-04-22
1502 A theory of brain-computer interface learning via low-dimensional control
Menendez, J. A.; Hennig, J. A.; Golub, M. D.; Oby, E. R.; Sadtler, P. T.; Batista, A. P.; Chase, S. M.; Yu, B. M.; Latham, P. E.
10.1101/2024.04.18.589952 — neuroscience — Posted on 2024-04-22
1503 Personality traits vary in their association with brain activity across situations.
Hardikar, S.; McKeown, B.; Turnbull, A.; Xu, T.; Valk, S. L.; Bernhardt, B.; Margulies, D.; Milham, M. P.; Jefferies, E.; Leech, R.; Villringer, A.; Smallwood, J.
10.1101/2024.04.18.590056 — neuroscience — Posted on 2024-04-22
1505 The selective 5-HT2A receptor agonist LPH-5 induces persistent and robust antidepressant-like effects in rodents
Jensen, A. A.; Cecchi, C. R.; Hibicke, M.; Bach, A. H.; Kaadt, E.; Marcher-Rorsted, E.; Nichols, C. D.; Elfving, B.; Kristensen, J. L. L.
10.1101/2024.04.19.590212 — neuroscience — Posted on 2024-04-22
1509 A rat model of cirrhosis with well-differentiated hepatocellular carcinoma induced by thioacetamide
Hu, Z.; Kurihara, T.; Sun, Y.; Cetin, Z.; Florentino, R. M.; Faccioli, L.; Liu, Z.; Yang, B.; Ostrowska, A.; Soto-Gutierrez, A.; Delgado, E.
10.1101/2024.04.18.590120 — pathology — Posted on 2024-04-22
1510 Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea
Meneux, L.; Feret, N.; Pernot, S.; Girard, M.; Sarkis, S.; Caballero Megido, A.; Quiles, M.; Fichter, L.; Vialaret, J.; Hirtz, C.; Delettre, C.; Michon, F.
10.1101/2024.04.18.590110 — pathology — Posted on 2024-04-22
1512 Morphogenesis of bacterial colonies in polymeric environments
La Corte, S. G.; Stevens, C. A.; Carcamo-Oyarce, G.; Ribbeck, K.; Wingreen, N. S.; Datta, S. S.
10.1101/2024.04.18.590088 — biophysics — Posted on 2024-04-22
1516 Lifting the curse from high dimensional data: Automated projection pursuit clustering for the variety of biological data modalities
Simpson, C.; Tabatsky, E.; Rahil, Z.; Eddins, D. J.; Tkachev, S.; Georgescauld, F.; Papalegis, D.; Culka, M.; Levy, T.; Gregoretti, I.; Chernyshev, A.; Koeppen, H.; Walther, G.; Ghosn, E. E. B.; Orlova, D.
10.1101/2024.04.18.589981 — bioinformatics — Posted on 2024-04-22
1517 A de novo variant in PAK2 detected in an individual with Knobloch type 2 syndrome
Werren, E. A.; Kalsner, L.; Ewald, J.; Peracchio, M.; King, C.; Vats, P.; Audano, P. A.; Robinson, P. N.; Adams, M. D.; Kelly, M. A.; Matson, A. P.
10.1101/2024.04.18.590108 — genomics — Posted on 2024-04-22
1519 Utility Analyses of AVITI Sequencing Chemistry
Liu, S.; Obert, C.; Yu, Y.; Zhao, J.; Ren, B.; Wiseman, K.; Krajacich, B. J.; Wang, W.; Metcalfe, K.; Smith, M.; Ben-Yehezkel, T.; Luo, J.
10.1101/2024.04.18.590136 — genomics — Posted on 2024-04-22
1520 Sucrase isomaltase dysfunction influences dietary sucrose intake and preference
Aldiss, P.; Torices, L.; Ramne, S.; Jorgensen, M. E.; Bonfiglio, F.; Burm, H.; Blanco, C. E.; Staeger, F. F. V.; Senftleber, N. K.; Treebak, J. T.; Grarup, N.; Bjerregaard, P.; Grevengoed, T. J.; Gillum, M. P.; Moltke, I.; Albrechtsen, A.; Hansen, T.; D'Amato, M.; Andersen, M. K.
10.1101/2024.04.18.590042 — genetics — Posted on 2024-04-22
1522 Herbivory can increase plant fitness via reduced interspecific competition. Evidence from models and mesocosms
Böttner, L.; Dudenhausen, F.; Nouere, S.; Malacrino, A.; Schäfer, M.; Koene, J. M.; Huber, M.; Xu, S.
10.1101/2024.04.20.589392 — ecology — Posted on 2024-04-22
1523 Combining in vivo and in vitro approaches to better understand host-pathogen interactions
Holdbrook, R.; Reavey, C. E.; Randall, J. L.; Andongma, A. A.; Tummala, Y.; Simpson, S. J.; Smith, J. A.; Cotter, S.; Wilson, K.
10.1101/2024.04.19.590205 — ecology — Posted on 2024-04-22
1524 Thymic stromal lymphopoietin contributes to endometriotic lesion proliferation and disease-associated inflammation.
Aleksieva, S.; Lingegowda, H.; Sisnett, D. J.; McCallion, A.; Zutautas, K. B.; Childs, T.; Lessey, B.; Tayade, C.
10.1101/2024.04.18.590132 — immunology — Posted on 2024-04-22
1529 The entangled world of DNA quadruplex folds
Sundaresan, S.; Uttamrao, P. P.; Kovuri, P.; Rathinavelan, T.
10.1101/2024.04.17.589856 — biochemistry — Posted on 2024-04-22
1530 Differential antigenic imprinting effects between influenza H1N1 hemagglutinin and neuraminidase in a mouse model
Lv, H.; Teo, Q. W.; Lee, C.-C. D.; Liang, W.; Choi, D.; Mao, K. J.; Bruzzone, R.; Wilson, I. A.; Wu, N. C.; Mok, C. K.
10.1101/2024.04.17.589918 — immunology — Posted on 2024-04-22
1531 Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking
Karashchuk, L.; Li, J. S. L.; Chou, G. M.; Walling-Bell, S.; Brunton, S. L.; Tuthill, J. C.; Brunton, B. W.
10.1101/2024.04.18.589965 — neuroscience — Posted on 2024-04-22
1532 Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALS
You, J.; Maksimovic, K.; Chen, K.; Lee, J.; Schoeppe, A.; Santos, J. R.; Youssef, M. M. M.; SALTER, M. W.; Park, J.
10.1101/2024.04.18.590117 — neuroscience — Posted on 2024-04-22
1534 The ANKS3/BICC1 protein complex is a master post-transcriptional regulator of NPHP1 ciliopathy gene transcripts
Mahuzier, A.; Odye, G.; Grampa, V.; Bizet, A. A.; Viau, A.; Ryan, R.; Mehraz, M.; Blisnick, T.; Clark, E.; Henry, C.; Piedagnel, R.; Silbermann, F.; Hayot, G.; De grande, L.; Kahn, A.; Plaza, J.-M.; Krug, P.; Knebelmann, B.; Muller, F.; BASTIN, P.; Sailer, A. W.; Saint-Mezard, P.; Jeanpierre, C.; Hoffmann, S.; Benmerah, A.; Lelongt, B.; DELOUS, M.; Saunier, S.
10.1101/2024.04.18.588747 — pathology — Posted on 2024-04-22
1536 A new targeting motif for endoplasmic reticulum surface proteins
Arad, S.; Suseendran, P.; Ravid, S.; Peleg, Y.; Ben-Dor, S.; Fidel, E.; Olender, T.; Wang, X.; Schuldiner, M.; Fenech, E. J.
10.1101/2024.04.22.590521 — cell biology — Posted on 2024-04-22
1537 Amino Acid and Glucose Fermentation Maintain ATP Content in Mouse and Human Malignant Glioma Cells
Lee, D. C.; Ta, L.; Mukherjee, P.; Duraj, T.; Domin, M.; Greenwood, B.; Karmacharya, S.; Narain, N. R.; Kiebish, M.; Chinopoulos, C.; Seyfried, T. N.
10.1101/2024.04.18.589922 — cancer biology — Posted on 2024-04-22
1540 Identification of Glucosidase II that regulates STIM1 activation dynamics
Du, Y.; Wang, Y.; Zhou, Y.; Wang, F.; Zheng, S.; Yuan, X.; Xi, C.; Li, J.
10.1101/2024.04.20.590316 — cell biology — Posted on 2024-04-22
1543 Predicting immunotherapy response in advanced bladder cancer: a meta-analysis of six independent cohorts
Boll, L. M.; Vazquez Montes de Oca, S.; Camarena, M. E.; Castelo, R.; Bellmunt, J.; Perera-Bel, J.; Alba, M. M.
10.1101/2024.04.18.589711 — cancer biology — Posted on 2024-04-22
1544 Novel endogenous engineering platform for robust loading and delivery of functional mRNA by extracellular vesicles
Zickler, A. M.; Liang, X.; de Luca, M.; Gupta, D.; Corso, G.; Errichelli, L.; Hean, J.; Kamei, N.; Niu, Z.; Zhou, G.; Roudi, S.; Nordin, J.; Castilla-Llorente, V.; EL Andaloussi, S.
10.1101/2023.03.17.533081 — bioengineering — Posted on 2024-04-22
1546 Body mass change over winter is consistently sex-specific across roe deer (Capreolus capreolus) populations
Hewison, A. J. M.; Bonnot, N.; Gaillard, J.-M.; Kjellander, P.; Lemaitre, J.-F.; Morellet, N.; Pellerin, M.
10.1101/2022.09.09.507329 — ecology — Posted on 2024-04-22
1547 How Mycobacterium tuberculosis builds a home: Single-cell analysis reveals M. tuberculosis ESX-1-mediated accumulation of anti-inflammatory macrophages in infected mouse lungs.
Zheng, W.; Borja, M.; Dorman, L.; Liu, J.; Zhou, A.; Seng, A.; Arjyal, R.; Sunshine, S.; Nalyvayko, A.; Pisco, A. O.; Rosenberg, O.; Neff, N.; Zha, B. S.
10.1101/2024.04.20.590421 — microbiology — Posted on 2024-04-22
1548 Psychobiological regulation of plasma and saliva GDF15 dynamics in health and mitochondrial diseases
Huang, Q.; Trumpff, C.; Monzel, A. S.; Rausser, S.; Haahr, R.; Devine, J.; Liu, C. C.; Kelly, C.; Thompson, E.; Kurade, M. S.; Michelson, J.; Shaulson, E. D.; Li, S.; Engelstad, K.; Tanji, K.; Lauriola, V.; Wang, T.; Wang, S.; Zuraikat, F. M.; St-Onge, M.-P.; Kaufman, B. A.; Sloan, R.; Juster, R.-P.; Marsland, A. L.; Gouspillou, G.; Hirano, M.; Picard, M.
10.1101/2024.04.19.590241 — physiology — Posted on 2024-04-22
1559 Limnospira (Cyanobacteria) chemical fingerprint reveals local molecular adaptation
Marie, B.; Roussel, T.; Hubas, C.; Halary, S.; Chynel, M.; Duval, C.; Cadoret, J.-P.; Meziane, T.; Vernes, L.; Yepremian, C.; Bernard, C.
10.1101/2024.04.19.590274 — microbiology — Posted on 2024-04-22
1561 Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans
Pant, R.; Pitchaimuthu, K.; Ossandon, J. P.; Shareef, I.; Lingareddy, S.; Finsterbusch, J.; Kekunnaya, R.; Röder, B.
10.1101/2024.04.18.590147 — neuroscience — Posted on 2024-04-22
1563 Induction by caterpillars of stored and emitted volatiles among populations of wild cotton (Gossypium hirsutum)
Mamin, M.; Clancy, M. V.; Fluckiger, G.; Quijano-Medina, T.; Perez-Nino, B.; Abdala-Roberts, L.; Turlings, T.; Bustos-Segura, C.
10.1101/2024.04.17.589906 — plant biology — Posted on 2024-04-22
1564 Maize stigmas react differently to self-/cross-pollination and fungal invasion
Begcy, K.; Mondragon-Palomino, M.; Zhou, L.-Z.; Seitz, P.-L.; Marton, M.-L.; Dresselhaus, T.
10.1101/2024.04.17.589941 — plant biology — Posted on 2024-04-22
1565 Integrating molecular and clinical variables to predict myocardial recovery
Visker, J. R.; Brintz, B. J.; Kyriakopoulos, C. P.; Hillas, Y.; Taleb, I.; Badolia, R.; Shankar, T. S.; Amrute, J. M.; Ling, J.; Hamouche, R.; Tseliou, E.; Navankasattusas, S.; Wever-Pinzon, O.; Ducker, G. S.; Holland, W. L.; Summers, S. A.; Koenig, S. C.; Hanff, T. C.; Lavine, K. J.; Murali, S.; Bailey, S.; Alharethi, R.; Selzman, C. H.; Shah, P.; Slaughter, M. S.; Kanwar, M. K.; Drakos, S. G.
10.1101/2024.04.16.589326 — physiology — Posted on 2024-04-22
1566 Branched chain amino acids modulate the proteomic profile of Pro-induced differentiation for the infective stages of Trypanosoma cruzi
De Freitas Nascimento, J.; Damasceno, F. S.; Marsiccobetre, S.; Vitorino, F. N. d. L.; Achjian, R. W.; da Cunha, J. P. C.; Silber, A. M.
10.1101/2024.04.17.589966 — biochemistry — Posted on 2024-04-22
1568 Efficient fine-tuning of endothelial gene expression by Y to Phe mutation in the VE-cadherin gene
GARNIER, O.; JEANNERET, F.; DURAND, A.; FERTIN, A.; Battail, C.; BERNDT, S.; CARPENTIER, G.; Martin, D.; VILGRAIN, I.
10.1101/2024.04.17.589974 — cell biology — Posted on 2024-04-22
1573 Sub-type specific connectivity between CA3 pyramidal neurons may underlie their sequential activation during sharp waves
Sammons, R. P.; Masserini, S.; Velasquez, L. M.; Metodieva, V. D.; Cano, G.; Sannio, A.; Orlando, M.; Maier, N.; Kempter, R.; Schmitz, D.
10.1101/2024.04.16.589773 — neuroscience — Posted on 2024-04-22
1575 Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment
Napoli, M.; Immler, R.; Rohwedder, I.; Lupperger, V.; Pfabe, J.; Gonzalez Pisfil, M.; Yevtushenko, A.; Vogl, T.; Roth, J.; Salvermoser, M.; Dietzel, S.; Slak Rupnik, M.; Marr, C.; Walzog, B.; Sperandio, M.; Pruenster, M.
10.1101/2024.04.16.589738 — physiology — Posted on 2024-04-22
1576 The splicing factor kinase SRPK1 is a therapeutic target for Peripheral Vascular Disease
Bhalla, S. R.; Wahid, M.; Amartey, J.; Riu, F.; Gao, Y.; Agrawal, J.; Lynch, A. P.; Hawtrey, T.; Kikuchi, R.; Green, K. R.; Teboul, L.; Allen, C.; Blackley, Z.; Rajaji, K.; Marsden, D.; Batson, J.; Harper, S. J.; Oltean, S.; Amoaku, W.; Benest, A. V.; Morris, J. C.; Braithwaite, B.; Bates, D. O.
10.1101/2024.04.17.589996 — physiology — Posted on 2024-04-22
1577 The Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin Inhibits Long QT 3 Late Sodium Currents in a Mutation Specific Manner
Lunsonga, L.; Fatehi, M.; Long, W.; Barr, A.; Gruber, B. E.; Chattopadhyay, A.; Barakat, K.; Edwards, A. G.; Light, P. E.
10.1101/2024.04.15.589662 — pharmacology and toxicology — Posted on 2024-04-22
1578 Interpretable antibody-antigen interaction prediction by introducing route and priors guidance
Liu, Y.; Nie, Z.; Chen, J.; Zheng, X.; Fu, J.; Liu, Z.; Liu, X.; Xu, F.; Huang, X.; Zhang, W.-B.; Ma, S.; Gao, W.; Tian, Y.
10.1101/2024.03.09.584264 — bioinformatics — Posted on 2024-04-21
1579 TCF4 trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophy
Saha, S.; Skeie, J. M.; Schmidt, G. A.; Eggleston, T.; Shevalye, H.; Sales, C. S.; Phruttiwanichakun, P.; Dusane, A.; Field, M.; Rinkoski, T. A.; Fautsch, M. P.; Baratz, K. H.; Roy, M.; Jun, A. S.; Salem, A. K.; Greiner, M. A.
10.1101/2022.06.27.497862 — cell biology — Posted on 2024-04-21
1580 Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A
Peng, Y.; Zhang, Y.; Fang, R.; Jiang, H.; Lan, G.; Xu, Z.; Liu, Y.; Nie, Z.; Ren, L.; Wang, F.; Zhang, S.-D.; Ma, Y.; Yang, P.; Ge, H.-H.; Zhang, W.-D.; Luo, C.; Li, A.; He, W.
10.1101/2023.04.25.538200 — cell biology — Posted on 2024-04-21
1583 A Novel Pan-Proteome Array for High-Throughput Profiling of the Humoral Response to Treponema pallidum subsp. pallidum: a Pre-Clinical Study
Campo, J. J.; Romeis, E.; Oberai, A.; Pablo, J.; Hung, C.; Teng, A.; Shandling, A. D.; Phan, A.; Haynes, A.; Giacani, L.
10.1101/2024.04.20.590429 — microbiology — Posted on 2024-04-21
1584 How Mycobacterium tuberculosis builds a home: Single-cell analysis reveals M. tuberculosis ESX-1-mediated accumulation of anti-inflammatory macrophages in infected mouse lungs.
Zheng, W.; Borja, M.; Dorman, L.; Liu, J.; Zhou, A.; Seng, A.; Arjyal, R.; Sunshine, S.; Nalyvayko, A.; Pisco, A. O.; Rosenberg, O.; Neff, N.; Zha, B. S. S.
10.1101/2024.04.20.590421 — microbiology — Posted on 2024-04-21
1585 KIRA6 is an effective and versatile mast cell inhibitor of IgE-mediated activation
Wilhelm, T.; Wunderle, V.; Boukeileh, S.; Gossen, J.; Margreiter, M. A.; Sakurov, R.; Capellmann, S.; Schwoerer, M.; Ahmed, N.; Bronneberg, G.; Arock, M.; Martin, C.; Schubert, T.; Levi-Schaffer, F.; Rossetti, G.; Tirosh, B.; Huber, M.
10.1101/2024.04.18.589885 — immunology — Posted on 2024-04-21
1586 Systematic genome-wide discovery of host factors governing bacteriophage infectivity
Chitboonthavisuk, C.; Martin, C.; Huss, P.; Peters, J. M.; Anantharaman, K.; Raman, S.
10.1101/2024.04.20.590424 — synthetic biology — Posted on 2024-04-21
1589 Detecting directed motion and confinement in single-particle trajectories using hidden variables
Simon, F.; Ramadier, G.; Fonquernie, I.; Zsok, J.; Patskovsky, S.; Meunier, M.; Boudoux, C.; Dultz, E.; Weiss, L. E.
10.1101/2024.04.18.589798 — biophysics — Posted on 2024-04-21
1593 CRISPR-Cas9 knockout screen informs efficient reduction of the Komagataella phaffii secretome
Dalvie, N. C.; Lorgeree, T. R.; Yang, Y.; Rodriguez-Aponte, S. A.; Whittaker, C. A.; Hinckley, J. A.; Clark, J. J.; Del Rosario, A. M.; Love, K. R.; Love, J. C.
10.1101/2024.04.21.590449 — bioengineering — Posted on 2024-04-21
1594 Nanodisc reconstitution and characterization of amyloid-β precursor protein C99
Krishnarjuna, B.; Sharma, G.; Hiiuk, V. M.; Struppe, J.; Nagorny, P.; Ivanova, M. I.; Ramamoorthy, A.
10.1101/2024.04.21.590446 — biochemistry — Posted on 2024-04-21
1595 Dietary stress induced macrophage metabolic reprogramming, a determinant of animal growth
Mahanta, A.; Najar, S. A.; Hariharan, N.; Goyal, M.; Subramanian, R.; Giangrande, A.; Palakodeti, D.; Mukherjee, T.
10.1101/2024.04.18.590077 — developmental biology — Posted on 2024-04-21
1596 Fmp40 ampylase regulates cell survival upon oxidative stress by controlling Prx1 and Trx3 oxidation
Kucharczyk, R.; Masanta, S.; Wiesyk, A.; Panja, C.; Pilch, S.; Ciesla, J.; Kasabula, M.; De, A.; Enkhbaatar, T.; Maslanka, R.; Skoneczna, A.
10.1101/2024.04.20.590396 — molecular biology — Posted on 2024-04-21
1597 Engineering, structure, and immunogenicity of a Crimean-Congo hemorrhagic fever virus pre-fusion heterotrimeric glycoprotein complex
McFadden, E.; Monticelli, S.; Wang, A.; Ramamohan, A.; Batchelor, T.; Kuehne, A.; Bakken, R.; Tse, A.; Chandran, K.; Herbert, A.; McLellan, J.
10.1101/2024.04.20.590419 — microbiology — Posted on 2024-04-21
1598 A Blueprint for Broadly Effective Bacteriophage Therapy Against Bacterial Infections
Kim, K. M.; Chen, Q.; Echterhof, A.; McBride, R. C.; Pennetzdorfer, N.; Banaei, N.; Burgener, E. B.; Milla, C. E.; Bollyky, P.
10.1101/2024.04.20.590411 — microbiology — Posted on 2024-04-21
1599 Commensal bacteria inhibit viral infections via a tryptophan metabolite
Jiang, D.; Soo, N.; Tan, C. Y.; Dankwa, S.; Wang, H.-Y.; Theriot, B. S.; Ardeshir, A.; Siddiqui, N. Y.; Van Rompay, K. K. A.; De Paris, K.; Permar, S. R.; Goswami, R.; Surana, N. K.
10.1101/2024.04.21.589969 — microbiology — Posted on 2024-04-21
1600 Component specific responses of the microbiomes to common chemical stressors in the human food chain
Wasimuddin, W.; Chiaia-Hernandez, A.; Terrettaz, C.; Thoenen, L.; Caggia, V.; Matteo, P.; Coll-Crespi, M.; Notter, M.; Mukherjee, M.; Chavez-Capilla, T.; Ronchi, F.; Ganal-Vonarburg, S. C.; Grosjean, M.; Bigalke, M.; Spielvogel, S.; Macpherson, A.; Mestrot, A.; Hapfelmeier, S.; Erb, M.; Schlaeppi, K.; Ramette, A.
10.1101/2024.04.20.590402 — microbiology — Posted on 2024-04-21
1603 The SPFH complex HflK-HflC regulates aerobic respiration in bacteria
Perez-Lopez, M. I.; Lubrano, P.; Angelidou, G.; Glatter, T.; Paczia, N.; Link, H.; Sourjik, V.
10.1101/2024.04.21.590321 — microbiology — Posted on 2024-04-21
1604 Gfi1 controls the formation of effector CD8 T cells during chronic infection and cancer
Ojo, O. A.; Shen, H.; Ingram, J. T.; Bonner, J. A.; Welner, R. S.; Lacaud, G.; Zajac, A. J.; Shi, L. Z.
10.1101/2024.04.18.579535 — immunology — Posted on 2024-04-21
1605 Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice.
Sakurai, K.; Morita, M.; Aomine, Y.; Matsumoto, M.; Moriyama, T.; Kasahara, E.; Sekiyama, A.; Otani, M.; Oshima, R.; Loveland, K. L.; Yamada, M.; Yoneda, Y.; Oka, M.; Hikida, T.; Miyamoto, Y.
10.1101/2024.04.18.590002 — neuroscience — Posted on 2024-04-21
1606 Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells
Hasko, J.; Feng, W.; Arshadi, A.; Tolomeo, D.; Hembo, C. S.; Petersen, T. S.; Lv, W.; Han, P.; Zeng, Y.; Wang, F.; Bolund, L.; Lin, L.; Regenberg, B.; Storlazzi, C. T.; Luo, Y.
10.1101/2024.04.18.590030 — cancer biology — Posted on 2024-04-21
1608 From Bulk to Binding: Decoding the Entry of PET into Hydrolase Binding Pockets
Jaeckering, A.; Goettsch, F.; Schaeffler, M.; Doerr, M.; Bornscheuer, U.; Wei, R.; Strodel, B.
10.1101/2024.04.21.590457 — bioengineering — Posted on 2024-04-21
1609 A Multi-Tissue Comparison and Molecular Characterization of Canine Organoids
Zdyrski, C.; Gabriel, V.; Ospina, O. E.; Wickham, H.; Sahoo, D. K.; Dao, K.; Aguilar Meza, L. S.; Ralston, A.; Bedos, L.; Bastian, W.; Honold, S.; Pineyro, P.; Douglass, E. F.; Mochel, J. P.; Allenspach, K.
10.1101/2022.07.15.500059 — genetics — Posted on 2024-04-21
1611 Highly multiplexed design of an allosteric transcription factor to sense novel ligands
Nishikawa, K. K.; Chen, J.; Acheson, J. F.; Harbaugh, S. V.; Huss, P.; Frenkel, M.; Novy, N.; Sieren, H. R.; Lodewyk, E. C.; Lee, D. H.; Chavez, J. L.; Fox, B. G.; Raman, S.
10.1101/2024.03.07.583947 — synthetic biology — Posted on 2024-04-21
1612 Keratin isoform shifts modulate motility signals during wound healing
Nanes, B. A.; Bhatt, K.; Boujemaa-Paterski, R.; Azarova, E.; Munawar, S.; Rajendran, D.; Isogai, T.; Dean, K. M.; Medalia, O.; Danuser, G.
10.1101/2023.05.04.538989 — cell biology — Posted on 2024-04-21
1613 LUC7 proteins define two major classes of 5' splice sites in animals and plants
Kenny, C. J.; McGurk, M. P.; Schuler, S.; Cordero, A.; Laubinger, S.; Burge, C. B.
10.1101/2022.12.07.519539 — molecular biology — Posted on 2024-04-21
1614 The representational geometry of emotional states in basolateral amygdala
O'Neill, P.-K.; Posani, L.; Meszaros, J.; Warren, P.; Schoonover, C. E.; Fink, A. J. P.; Fusi, S.; Salzman, C. D.
10.1101/2023.09.23.558668 — neuroscience — Posted on 2024-04-21
1615 Rostral Pedunculopontine Nucleus Infusion of M4 Positive Allosteric Modulator VU0467154 Augments L-DOPA Effects in Hemiparkinsonian Rats
Chambers, N. E.; MClune, A.; Coyle, M.; Centner, A.; Sergio, J.; Del Priore, I.; Lanza, K.; Lindsley, C. W.; Conn, P. J.; Bishop, C.
10.1101/2024.04.16.589785 — neuroscience — Posted on 2024-04-21
1616 Neuroticism/negative emotionality is associated with increased reactivity to uncertain threat in the bed nucleus of the stria terminalis, not the amygdala
Grogans, S. E.; Hur, J.; Barstead, M. G.; Anderson, A. S.; Islam, S.; Kim, H. C.; Kuhn, M.; Tillman, R. M.; Fox, A. S.; Smith, J. F.; DeYoung, K. A.; Shackman, A. J.
10.1101/2023.02.09.527767 — neuroscience — Posted on 2024-04-21
1618 Cell Type-specific Hypothalamic Pathways to Brainstem Drive Context-dependent Strategies in Response to Stressors
Ahmadlou, M.; Giannouli, M.; van Vierbergen, J. F. M.; van Leeuwen, T.; Bloem, W.; Houba, J. H. W.; Yasamin Shirazi, M.; Cazemier, J. L.; Haak, R.; Dubey, M.; de Winter, F.; Heimel, J. A.
10.1101/2023.03.10.532043 — neuroscience — Posted on 2024-04-21
1622 GIGANTEA is required for circadian rhythms in wheat
Taylor, L. J.; Steed, G.; Pingarron-Cardenas, G.; Wittern, L.; Hannah, M. A.; Webb, A. A.
10.1101/2024.04.19.590265 — plant biology — Posted on 2024-04-21
1624 Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice
Altes, G.; Olomi, A.; Perramon-Guell, A.; Hernandez, S.; Casanovas, A.; Perez, A.; Diaz-Tocados, J. M.; Valdivielso, J. M.; Megino, C.; Navaridas, R.; Matias-Guiu, X.; Klein, O. D.; Egea, J.; Dolcet, X.; Yeramian, A.; Encinas, M.
10.1101/2024.04.18.590049 — physiology — Posted on 2024-04-21
1625 How to deal with internal fragment ions?
Grimaud, A.; Babovic, M.; Haugaard Holck, F.; Jensen, O. N.; Schwämmle, V.
10.1101/2024.04.18.589916 — bioinformatics — Posted on 2024-04-21
1626 A miniaturised semi-dynamic in-vitro model of human digestion
Calero, V.; Rodrigues, P. M.; Dias, T.; Ainla, A.; Vilaca, A.; Pastrana, L.; Xavier, M.; Goncalves, C.
10.1101/2024.04.17.589902 — bioengineering — Posted on 2024-04-21
1627 Genetic purging of strongly deleterious mutations underlies black-necked crane's unusual escape from an extinction vortex
Cui, N.; Ma, X.; Wu, H.; Chen, X.; Hung, C.-M.; Zhang, L.; Lei, F.; Yang, L.; Yan, D.; Yang, X.; Dong, F.
10.1101/2024.04.18.590004 — evolutionary biology — Posted on 2024-04-21
1631 DOES EXPERIENCE MODULATE AUTOMATIC IMITATION? A NEW LOOK
Genovese, F.; Fanghella, M.; Sinigaglia, C.; Barchiesi, G.
10.1101/2024.04.17.589868 — neuroscience — Posted on 2024-04-21
1634 New role of cardiomyocyte Bmal1 in the regulation of sex-specific heart transcriptomes
Zhang, X.; Procopio, S. B.; Ding, H.; Semel, M. G.; Schroder, E. A.; Seward, T. S.; Du, P.; Wu, K. K.; Johnson, S. R.; Prabhat, A.; Schneider, D. J.; Stumpf, I. G.; Rozmus, E. R.; Huo, Z.; Delisle, B. P.; Esser, K. A.
10.1101/2024.04.18.590181 — physiology — Posted on 2024-04-21
1637 Transcriptional Variabilities in Human hiPSC-derived Cardiomyocytes: All Genes Are Not Equal and Their Robustness May Foretell Donor's Disease Susceptibility
Gu, C. C.; Matter, A.; Turner, A.; Aggarwal, P.; Yang, W.; Sun, X.; Hunt, S. C.; Lewis, C. E.; Arnett, D. K.; Anson, B.; Kattman, S.; Broeckel, U.
10.1101/2024.04.18.584138 — genetics — Posted on 2024-04-21
1638 AMHY and sex determination in egg-laying mammals
Shearwin-Whyatt, L.; Fenelon, J.; Yu, H.; Major, A.; Qu, Z.; Zhou, Y.; Shearwin, K.; Galbraith, J.; Stuart, A.; Adelson, D.; Zhang, G.; Pyne, M.; Johnston, S.; Smith, C.; Renfree, M. B.; Grützner, F.
10.1101/2024.04.18.588952 — evolutionary biology — Posted on 2024-04-21
1639 Matrix Vesicles from Osteoblasts Promote Atherosclerotic Calcification
Liu, X.; Wang, X.; Ren, J.; Zhang, Z.; Fang, F.; Wang, E.; Li, J.; He, W.; Shen, Y.
10.1101/2024.04.18.590180 — cell biology — Posted on 2024-04-21
1640 Elevated DNA Damage without signs of aging in the short-sleeping Mexican Cavefish
Lloyd, E.; Xia, F.; Moore, K.; Zertuche, C.; Rastogo, A.; Kozol, R.; Kenzior, O.; Warren, W. C.; Appelbaum, L.; Moran, R. L.; Zhao, C.; Duboue, E. R.; Rohner, N. R.; Keene, A. C.
10.1101/2024.04.18.590174 — neuroscience — Posted on 2024-04-21
1642 Spatial mapping reveals unique cellular interactions and enhanced tertiary lymphoid structures in responders to anti-PD-1 therapy in mucosal head and neck cancers.
Ferguson, A. L.; Beddow, T.; Patrick, E.; Willie, E.; Elliott, M. S.; Low, T.-H.; Wykes, J.; Hui, M. H.; Palme, C. E.; Boyer, M.; Clark, J. R.; Lee, J. H.; Palendira, U.; Gupta, R.
10.1101/2024.04.18.590189 — cancer biology — Posted on 2024-04-21
1644 Reconstructing prehistoric viral genomes from Neanderthal sequencing data
Ferreira, R. C.; Alves, G. V.; Ramon, M.; Antoneli, F. M.; Briones, M. R.
10.1101/2023.03.16.532919 — genomics — Posted on 2024-04-21
1645 Properties of the Ureaplasma parvum SMC protein related to its interaction with DNA
Rumyantseva, N. A.; Shutov, V. M.; Belenkaia, D. G.; Alekseev, A. A.; Morozova, N. E.; Vedyaykin, A. D.
10.1101/2024.04.14.589448 — molecular biology — Posted on 2024-04-21
1646 MePHD1.2 affects the synthesis of cyanogenic glycosides by regulating the transcription of MeCYP79D2 in cassava
Li, M.; Zhao, X.; Li, Y.; Zhao, X.; Mai, W.; Li, Y.; Liang, Q.; Yin, Q.; Wang, W.; Liu, J.; Chen, X.
10.1101/2024.04.18.590026 — molecular biology — Posted on 2024-04-21
1649 Pinging the Hidden Attentional Priority Map: Suppression Needs Attention
Huang, C.; van Moorselaar, D.; Foster, J. J.; Donk, M.; Theeuwes, J.
10.1101/2024.04.17.589855 — neuroscience — Posted on 2024-04-21
1651 A novel iPSC-based model of ICF syndrome subtype 2 recapitulates the molecular phenotype of ZBTB24 deficiency
Lullo, V.; Cecere, F.; Batti, S.; Allegretti, S.; Morone, B.; Fioriniello, S.; Pisapia, L.; Genesio, R.; Della Ragione, F.; Giardino, G.; Pignata, C.; riccio, a.; Matarazzo, M. R.; Strazzullo, M.
10.1101/2024.04.19.590250 — genetics — Posted on 2024-04-21
1652 Sex-specific competitive social feedback amplifies the role of early life contingency in male mice
Zipple, M. N.; Chang Kuo, D.; Meng, X.; Reichard, T. M.; Guess, K.; Vogt, C. C.; Moeller, A.; Sheehan, M. J.
10.1101/2024.04.19.590322 — evolutionary biology — Posted on 2024-04-21
1654 Functional traits and phylogeny predict vertical foraging in terrestrial mammals and birds
Jantz, P.; Abraham, A.; Scheffers, B.; Gaillard, C.; Harfoot, M.; Goetz, S.; Doughty, C.
10.1101/2024.04.18.589860 — ecology — Posted on 2024-04-21
1655 Nuclear speckle rejuvenation alleviates proteinopathies at the expense of YAP1
Dion, W.; Tao, Y.; Chambers, M.; Zhao, S.; Arbuckle, R. K.; Sun, M.; Kubra, S.; Nie, Y.; Ye, M.; Larsen, M. B.; Camarco, D.; Ickes, E.; DuPont, C.; Wang, H.; Wang, B.; Liu, S.; Pi, S.; Chen, B. B.; Chen, Y.; Chen, X.; Zhu, B.
10.1101/2024.04.18.590103 — cell biology — Posted on 2024-04-21
1656 Myosin II actively regulates Drosophila proprioceptors
Guan, C.; Nishi, K.; Kreis, C. T.; Baeumchen, O.; Goepfert, M. C.; Schmidt, C. F.
10.1101/2024.04.18.590050 — cell biology — Posted on 2024-04-21
1657 Enforced MYC expression selectively redirects transcriptional programs during human plasma cell differentiation
Vardaka, P.; Page, E.; Care, M.; Stephenson, S.; Kemp, B.; Umpierrez, M.; O'Callaghan, E.; Mabbutt, A.; Owen, R.; Hodson, D. J.; Doody, G. M.; Tooze, R.
10.1101/2024.04.18.589889 — cell biology — Posted on 2024-04-21
1658 BNST GluN2D-containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice
Doyle, M. A.; Salimando, G. J.; Altemus, M. E.; Badt, J. K.; Bedenbaugh, M. N.; Vardy, A. S.; Adank, D. N.; Park, A. S.; Winder, D. G.
10.1101/2024.04.19.590258 — neuroscience — Posted on 2024-04-21
1659 Psychobiological regulation of plasma and saliva GDF15 dynamics in health and mitochondrial diseases
Huang, Q.; Trumpff, C.; Monzel, A. S.; Rausser, S.; Haahr, R.; Devine, J.; Liu, C. C.; Kelly, C.; Thompson, E.; Kurade, M. S.; Shaulson, E. D.; Li, S.; Engelstad, K.; Tanji, K.; Lauriola, V.; Wang, T.; Wang, S.; Zuraikat, F. M.; St-Onge, M.-P.; Kaufman, B. A.; Sloan, R.; Juster, R.-P.; Marsland, A. L.; Gouspillou, G.; Hirano, M.; Picard, M.
10.1101/2024.04.19.590241 — physiology — Posted on 2024-04-21
1661 Point contact-restricted cAMP signaling controls ephrin-A5-induced axon repulsion
Becret, J.; Michaud, C.; Assali, A.; Chenais, N. A. L.; Kankadze, I.; Gomez-Bravo, C.; Roche, F.; Couvet, S.; Fassier, C.; Nicol, X.
10.1101/2024.04.20.589861 — developmental biology — Posted on 2024-04-21
1666 Analog epigenetic cell memory by graded DNA methylation
Palacios, S.; Bruno, S.; Weiss, R.; Salibi, E.; Kane, A.; Ilia, K.; Del Vecchio, D.
10.1101/2024.02.13.580200 — bioengineering — Posted on 2024-04-20
1667 Phase separation of a microtubule plus-end tracking protein into a fluid fractal network
Czub, M. P.; Uliana, F.; Grubic, T.; Padeste, C.; Rosowski, K. A.; Dufresne, E. R.; Menzel, A.; Vakonakis, I.; Gasser, U.; Steinmetz, M. O.
10.1101/2024.04.19.590270 — biochemistry — Posted on 2024-04-20
1668 Dynamic simulations of feeding and respiration of the early Cambrian periderm-bearing cnidarian polyps
Zhang, Y.; Wang, X.; Han, J.; Xiao, J.; Yong, Y.; Yu, C.; Yue, N.; Sun, J.; He, K.; Hao, W.; Zhang, T.; Wang, B.; Wang, D.; Yang, X.
10.1101/2023.07.28.550931 — evolutionary biology — Posted on 2024-04-20
1670 Addressing the Southeast Asian snaring crisis: impact of 11 years of snare removal in a biodiversity hotspot
Tilker, A.; Niedballa, J.; Viet, H. L.; Abrams, J. F.; Marescot, L.; Wilkinson, N.; Rawson, B. R.; Sollmann, R.; Wilting, A.
10.1101/2023.01.26.525728 — ecology — Posted on 2024-04-20
1672 Improved vascularized lymph node transfer by periodic injection of hyaluronidase in a rodent model
Cheon, H.; Chen, L.; Kim, S.-A.; Gelvosa, N.; Hong, J. P.; Jeon, J. Y.; Suh, H. S. P.
10.1101/2024.04.18.586511 — physiology — Posted on 2024-04-20
1673 Multi-omic Analysis Identifies Glioblastoma Dependency on H3K9me3 Methyltransferase Activity
Xie, Q.; Du, Y.; Ghosh, S.; Rajendran, S.; Cohen-Gadol, A.; Baizabal, M.; Nephew, K. P.; Han, L.; Shen, J.
10.1101/2024.04.18.590173 — cancer biology — Posted on 2024-04-20
1674 Stochastic modelling of single-cell gene expression adaptation reveals non-genomic contribution to evolution of tumor subclones
Hirsch, M. G.; Pal, S.; Mehrabadi, F. R.; Malikic, S.; Gruen, C.; Sassano, A.; Perez-Guijarro, E.; Merlino, G.; Sahinalp, C.; Molloy, E.; Day, C.-P.; Przytycka, T. M.
10.1101/2024.04.17.588869 — cancer biology — Posted on 2024-04-20
1675 Cholesterol Dependence on the Conformational Changes of Metabotropic Glutamate Receptor 1
Isu, U. H.; Badiee, S. A.; Polasa, A.; Tabari, S. H.; Derakhshani-Molayousefi, M.; Moradi, M.
10.1101/2024.04.17.589854 — biophysics — Posted on 2024-04-20
1677 InstructPLM: Aligning Protein Language Models to Follow Protein Structure Instructions
Qiu, J.; Xu, J.; Hu, J.; Cao, H.; Hou, L.; Gao, Z.; Zhou, X.; Li, A.; Li, X.; Cui, B.; Yang, F.; Peng, S.; Sun, N.; Wang, F.; Pan, A.; Tang, J.; Ye, J.; Lin, J.; Tang, J.; Huang, X.; Heng, P. A.; Chen, G.
10.1101/2024.04.17.589642 — bioinformatics — Posted on 2024-04-20
1680 Two dynamic, N-terminal regions are required for function in Ribosomal RNA Adenine Dimethylase family members
McGaha, D. A.; Collins, A.; Ajisafe, L. O.; Perdigao, C. C.; Bondrowski, J. L.; Fetsch, K.; Dunkle, J. A.
10.1101/2024.04.19.590347 — biochemistry — Posted on 2024-04-20
1681 Long-read sequencing and structural variant characterization in 1,019 samples from the 1000 Genomes Project
Schloissnig, S.; Pani, S.; Rodriguez-Martin, B.; Ebler, J.; Hain, C.; Tsapalou, V.; Soylev, A.; Huether, P.; Ashraf, H.; Prodanov, T.; Asparuhova, M.; Hunt, S.; Rausch, T.; Marschall, T.; Korbel, J. O.
10.1101/2024.04.18.590093 — genomics — Posted on 2024-04-20
1685 Gill regeneration in the mayfly Cloeon uncovers new molecular pathways in insect regeneration
Martin-Blanco, C. A.; Navarro, P.; Esteban-Collado, J.; Serras, F.; Almudi, I.; Casares, F.
10.1101/2024.04.17.589898 — developmental biology — Posted on 2024-04-20
1687 Single-embryo metabolomics reveals developmental metabolism in the early Drosophila embryo
Perez-Mojica, J. E.; Madaj, Z. B.; Isaguirre, C. N.; Roy, J.; Lau, K. H.; Sheldon, R. D.; Lempradl, A.
10.1101/2024.04.17.589796 — developmental biology — Posted on 2024-04-20
1688 Iron transport pathways in the human malaria parasite Plasmodium falciparum revealed by RNA-sequencing
Wunderlich, J.; Kotov, V.; Votborg-Novel, L.; Ntalla, C.; Geffken, M.; Peine, S.; Portugal, S.; Strauss, J.
10.1101/2024.04.18.590068 — cell biology — Posted on 2024-04-20
1692 A chimeric viral platform for directed evolution in mammalian cells
Cole, A. J.; Denes, C. E.; Moreno, C. L.; Dobson, T.; Hesselson, D.; Neely, G. G.
10.1101/2024.04.20.590384 — molecular biology — Posted on 2024-04-20
1695 Glycogen phase separation drives macromolecular rearrangement and asymmetric division in E. coli
Thappeta, Y.; Canas-Duarte, S. J.; Kallem, T.; Fragasso, A.; Xiang, Y.; Gray, W.; Lee, C.; Cegelski, L.; Jacobs-Wagner, C.
10.1101/2024.04.19.590186 — microbiology — Posted on 2024-04-20
1696 Autoaggregation in Streptococcus intermedius is driven by the Pel polysaccharide
Raju, D.; Turner, S. A.; Castro, K.; Whitfield, G. B.; LaMarche, D.; Mahajan, S.; Pfoh, R.; Le Mauff, F.; Joe, M.; Sarkar, S.; Lowary, T. L.; Sheppard, D. C.; Wozniak, D. J.; Surette, M. G.; Howell, P. L.
10.1101/2024.04.20.589940 — microbiology — Posted on 2024-04-20
1698 Advancing Tolerogenic Immunotherapy: A Multi-Epitope Vaccine Design Targeting the CYP2D6 Autoantigen in Autoimmune Hepatitis Through Immuno-Informatics
Kolla, H. B.; Kumar, A.; Nanjunadappa, R. H.; Hilyard, B.; Dutt, M.; Chauhan, D.; Marshall, J.; Kelvin, D.; Umeshappa, C. S.
10.1101/2024.04.17.589809 — immunology — Posted on 2024-04-20
1699 Dynamic modelling of signalling pathways when ODEsare not feasible
Rachel, T. J.; Brombacher, E.; Woehrle, S.; Gross, O.; Kreutz, C.
10.1101/2024.04.18.590024 — systems biology — Posted on 2024-04-20
1700 Nutribloods: novel synthetic lepidopteran haemolymphs for understanding insect-microbe interactions in vitro
Holdbrook, R.; Randall, J. L.; Reavey, C. E.; Andongma, A. A.; Rice, A.; Smith, J. A.; Simpson, S.; Cotter, S.; Wilson, K.
10.1101/2024.04.17.589926 — physiology — Posted on 2024-04-20
1703 Effect of urbanisation on soil and plant pollution in province of Valencia, Spain
Edina, S.; Bin, I. H.; Sipos, B.; Abriha-Molnar, V. E.; Abriha, D.; Andreu-Sanchez, O.; Boluda, R.; Perez, L. R.
10.1101/2024.03.27.586674 — ecology — Posted on 2024-04-20
1704 IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat
Brunetta, H. S.; Jung, A. S.; Valdivieso-Rivera, F. B.; Zani, S. C. C.; Furino, V.; Francisco, A.; Moraes-Vieira, P. M. M.; Keipert, S.; Jastroch, M.; Martinez, L. O.; Sponton, C. H.; Castilho, R. F.; Mori, M. A.; Bartelt, A.
10.1101/2023.07.27.550888 — cell biology — Posted on 2024-04-20
1705 Loss of developmentally derived Irf8+ macrophages promotes hyperinnervation and arrhythmia in the adult zebrafish heart
Paquette, S. E.; Oduor, C. I.; Gaulke, A.; Stefan, S.; Bronk, P.; Dafonseca, V.; Barulin, N.; Lee, C.; Carley, R.; Morrison, A. R.; Choi, B.-R.; Bailey, J. A.; Plavicki, J. S.
10.1101/2024.04.17.589909 — systems biology — Posted on 2024-04-20
1707 Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Vlachavas, E. I.; Voutetakis, K.; Kosmidou, V.; Tsikalakis, S.; Roditis, S.; Pateas, K.; Kim, R.; Pagel, K.; Wolf, S.; Warsow, G.; Dimitrakopoulou-Strauss, A.; Zografos, G. N.; Pintzas, A.; Betge, J.; Papadodima, O.; Wiemann, S.
10.1101/2024.04.17.589725 — cancer biology — Posted on 2024-04-20
1708 5'-S-(3-aminophenyl)-5'-thioadenosine, a novel chemoprotective agent for reducing toxic side effects of fluorouracil in treatment of MTAP-deficient cancers
Zhang, S.; Xue, H.; Wong, N. K. Y.; Doerksen, T.; Ban, F.; Anderson, S.; Volik, S.; Lin, Y.-Y.; Dai, Z.; Bratanovic, I.; Cheng, H.; Collins, C. C.; Cherkasov, A.; Wulff, J.; Wang, Y.
10.1101/2024.04.17.589975 — cancer biology — Posted on 2024-04-20
1709 Circulating tumor cells shed large extracellular vesicles in capillary-sized bifurcations
Vrynas, A.; Arfan, S.; Satia, K.; Bazban-Shotorbani, S.; Ashna, M.; Zhang, A.; Visan, D.; Chen, A.; Carter, M.; Blackhall, F.; Simpson, K.; Dive, C.; Huang, P. H.; Au, S. H.
10.1101/2024.04.17.589880 — cancer biology — Posted on 2024-04-20
1710 Multi-omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma
Staaf, J.; Ehinger, D.; Brunnström, H.; Jönsson, M.; Rosengren, F.; Kotevska, M.; Karlsson, A.; Aine, M.; Frezza, C.; Planck, M.; Arbajian, E.
10.1101/2024.04.17.589879 — cancer biology — Posted on 2024-04-20
1713 A cross-species framework for investigating perceptual evidence accumulation
Chakravarty, S.; Delgado-Sallent, C.; Kane, G. A.; Xia, H.; Do, Q.; Senne, R. A.; Scott, B.
10.1101/2024.04.17.589945 — animal behavior and cognition — Posted on 2024-04-20
1718 First endangered black-footed ferrets, Mustela nigripes, cloned for genetic rescue
Novak, B. J.; Gober, P.; Bortner, R.; Garelle, D.; Wright, M.; Novak, J.; Houck, M. L.; Ryder, O. A.; Milutinovich, D.; Benavidez, J.; Ryan, K.; Walker, S.; Arenivas, S. S.; Aston, L.; Russell, B.; Marinari, P.; Crosier, A.; Helmick, K.; Gibson, M. R.; Carlson, D. P.; Swanson, B. J.; Wisely, S. M.; White, Z. S.; Lynch, C.; Phelan, R.
10.1101/2024.04.17.589896 — zoology — Posted on 2024-04-20
1720 A high-continuity and annotated reference genome of allotetraploid Siberian wildrye (Elymus sibiricus L., Poaceae: Triticeae)
Yan, J.; Li, X.; Wang, L.; Li, D.; Ji, C.; Yang, Z.; Chen, L.; Zhang, C.; You, M.; Yan, L.; Gou, W.; Lei, X.; Ji, X.; Li, Y.; Wu, Q.; Mao, D.; Chang, D.; Jia, S.; Li, P.; Zhang, J.; Xiong, Y.; Xiong, Y.; Han, M.; Chen, Z.; Cheng, X.; Tang, J.; Xie, W.; Liu, W.; Zheng, H.; Ma, X.; Yan, X.; Bai, S.
10.1101/2024.04.17.589894 — genomics — Posted on 2024-04-20
1722 Loss of VPS41 triggers rapid insulin degradation and dysregulated autophagy in pancreatic beta-cells
Yau, B.; An, Y.; Germanos, M.; Schwarzkopf, P.; van der Kraan, G.; Larance, M.; Burns, C.; Asensio, C.; Kebede, M. A.
10.1101/2024.04.17.589848 — cell biology — Posted on 2024-04-20
1723 Mechanisms of Meiotic Spindle Initiation in Caenorhabditis elegans Oocytes
Gong, T.; McNally, K. P.; Konanoor, S.; Peraza, A.; Bailey, C.; Redemann, S.; McNally, F.
10.1101/2024.04.19.590357 — cell biology — Posted on 2024-04-20
1724 The Glycolytic Metabolite Methylglyoxal Covalently Inactivates the NLRP3 Inflammasome.
Stanton, C.; Buasakdi, C.; Sun, J.; Levitan, I.; Bora, P.; Kutseikin, S.; Wiseman, L.; Bollong, M.
10.1101/2024.04.19.589802 — cell biology — Posted on 2024-04-20
1725 Activity based proteome profiling of serum serinehydrolases: application in pediatric abusive head trauma
Sajic, T.; Maret, E.; Wiskott, K.; Shipley, T.; Gilardi, F.; Augsburger, M.; Thomas, A.; Fracasso, T.
10.1101/2024.04.17.589869 — neuroscience — Posted on 2024-04-20
1726 Multiscale modelling of neuronal dynamics in hippocampus CA1
Tesler, F.; Lorenzi, R. M.; Ponzi, A.; Castellato, C.; Palesi, F.; Gandolfi, D.; Gandini Wheeler Kingshott, C. A. M.; Mapelli, J.; D'Angelo, E.; Migliore, M.; Destexhe, A.
10.1101/2024.04.17.589863 — neuroscience — Posted on 2024-04-20
1728 Nuclear size-regulated emergence of topological packing order on growing human lung alveolospheres
Tang, W.; Huang, J.; Pegoraro, A. F.; Zhang, J. H.; Tang, Y.; Bi, D.; Kotton, D. N.; Guo, M.
10.1101/2024.04.17.589951 — biophysics — Posted on 2024-04-20
1733 Comprehensive Whole Genome Sequencing Reveals Origins of Mutational Signatures Associated with Aging and Temozolomide Chemotherapy
Hwang, T.; Sitko, L. K.; Khoirunnisa, R.; Aguad, F. N.; Samuel, D. M.; Park, H.; Cheon, B.; Mutsnaini, L.; Lee, J.; Takeda, S.; Lee, S.; Ivanov, D.; Gartner, A.
10.1101/2024.04.17.590003 — genomics — Posted on 2024-04-20
1735 Placental malaria is associated with a TLR-Endothelin-3-oxidative damage response in human placenta tissues
Chenge, S.; Mbalitsi, M.; Ngure, H.; Obimbo, M.; Singoei, M.; Kangogo, M.; Kanoi, B. N.; Gitaka, J.; Kobia, F. M.
10.1101/2024.04.17.589949 — cell biology — Posted on 2024-04-20
1743 Biosynthesis of Arcyriaflavin F from Streptomyces venezuelae ATCC 10712
Lai, H.-E.; Tanner, L.; Kennedy, A.; Chee, S. M.; Freemont, P.; Moore, S.
10.1101/2024.04.17.589956 — microbiology — Posted on 2024-04-20
1744 A Membrane Lipid Signature Unravels the Dynamic Landscape of Group 1 ILCs
Frey, H.; Sun, X.; Oudeif, F.; Corona, D.; He, Z.; Won, T.; Schultz, T. L.; Carruthers, V. B.; Laouar, A.; Laouar, Y.
10.1101/2024.04.17.589821 — immunology — Posted on 2024-04-20
1745 Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1
Pan, J.; Tong, X.; Ding, Y.; Lei, C.; Wei, S.; Xu, A.; Han, Y.; Qiu, Q.; Pang, H.; Hu, X.; Gong, C.; Zhu, M.
10.1101/2024.04.17.590017 — immunology — Posted on 2024-04-20
1747 Neurophysiological Patterns of Attention and Distraction during Realistic Virtual-Reality Classroom Learning in Adults with and without ADHD
Levy, O.; Libman Hackmon, S.; Zvilichovsky, Y.; Korisky, A.; Bidet-Caulet, A.; Schweitzer, J. B.; Zion Golumbic, E.
10.1101/2024.04.17.590012 — neuroscience — Posted on 2024-04-20
1751 Endothelial c-Src mediates neovascular tuft formation in Oxygen-Induced Retinopathy
Frampton, E.; Som, P.; Hill, B.; Yu, A.; Noordstra, I.; Gordon, E.; Schimmel, L.
10.1101/2024.04.17.589627 — pathology — Posted on 2024-04-20
1752 Treatment options for Chagas Disease: a systematic review and meta-analysis applied to the preclinical studies using animal models
Machaca Luque, L. Y.; Candia Puma, M. A.; Roque Pumahuanca, B. M.; Barazorda-Ccahuana, H. L.; Goyzueta Mamani, L. D.; Sobreira Galdino, A.; Machado de Avila, R. A.; Cordeiro Giunchetti, R.; Ferraz Coelho, E. A.; Chavez Fumagalli, M. A.
10.1101/2024.04.17.589953 — pathology — Posted on 2024-04-20
1753 Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer
Yedier-Bayram, O.; Cingoz, A.; Yilmaz, E.; Aksu, A. C.; Esin, B.; Pinarbasi Degirmenci, N.; Cavga, A. D.; Dedeoglu, B.; Cevatemre, B.; Syed, H.; Philpott, M.; Cribbs, A. P.; Oppermann, U.; Lack, N.; ACILAN AYHAN, C.; Onder, T. T.; Bagci-Onder, T.
10.1101/2024.04.16.587277 — cancer biology — Posted on 2024-04-20
1756 scCaT: an explainable capsulating architecture for sepsis diagnosis transferring from single-cell RNA sequencing
Zheng, X.; Meng, D.; Chen, D.; Wong, W.-K.; To, K.-H.; Zhu, L.; Wu, J.; Liang, Y.; Leung, K.-S.; Wong, M.-H.; Cheng, L.
10.1101/2024.04.17.590014 — bioinformatics — Posted on 2024-04-20
1758 Quantifying spontaneous infant movements using state-space models
Passmore, E.; Kwong, A. K. L.; Olsen, J. E.; Eeles, A.; Cheong, J. L. Y.; Spittle, A. J.; Ball, G.
10.1101/2024.04.16.589847 — bioengineering — Posted on 2024-04-20
1760 Sickness behaviour within cleaning interactions
Marques, T. R. S.; Pereira, B.; Marques, M.; Repolho, T.; Paula, J. R.
10.1101/2024.04.17.589989 — animal behavior and cognition — Posted on 2024-04-20
1761 Balancing selection and the functional effects of shared polymorphism in cryptic Daphnia species
Murray, C. S.; Karram, M.; Bass, D. J.; Doceti, M.; Becker, D.; Nunez, J. C. B.; Ratan, A.; Bergland, A. O.
10.1101/2024.04.16.589693 — evolutionary biology — Posted on 2024-04-20
1765 Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations
Reddy, J. S.; Heath, L.; Linden, A. V.; Allen, M.; Lopes, K. d. P.; Seifar, F.; Wang, E.; Ma, Y.; Poehlman, W.; Quicksall, Z. S.; Runnels, A.; Wang, Y.; Duong, D. M.; Yin, L.; Xu, K.; Modeste, E. S.; Shantaraman, A.; Dammer, E. B.; Ping, L.; Oatman, S. R.; Scanlan, J.; Ho, C.; Carrasquillo, M. M.; Atik, M.; Yepez, G.; Mitchell, A. O.; Nguyen, T. T.; Chen, X.; Marquez, D. X.; Reddy, H.; Xiao, H.; Seshadri, S.; Mayeux, R.; Prokop, S.; Lee, E. B.; Serrano, G. E.; Beach, T. G.; Teich, A. F.; Haroutunian, V.; Fox, E. J.; Gearing, M.; Wingo, A.; Wingo, T.; Lah, J. J.; Levey, A. I.; Dickson, D. W.; B
10.1101/2024.04.16.589592 — neuroscience — Posted on 2024-04-20
1766 Prolonged signaling of backbone-modified glucagon-like peptide-1 analogues with diverse receptor trafficking
Cary, B. P.; Hager, M. V.; Morris, R. K.; Belousoff, M. J.; Sexton, P. M.; Wootten, D.; Gellman, S. H.
10.1101/2024.04.17.589632 — pharmacology and toxicology — Posted on 2024-04-20
1778 Rostral Pedunculopontine Nucleus Infusion of M4 Positive Allosteric Modulator VU0467154 Augments L-DOPA Effects in Hemiparkinsonian Rats
Chambers, N. E.; MClune, A.; Coyle, M.; Centner, A.; Sergio, J.; Del Priore, I.; Lanza, K.; Lindsley, C. W.; Conn, P. J.; Bishop, C.
10.1101/2024.04.16.589785 — neuroscience — Posted on 2024-04-20
1779 Regional Glymphatic Dysfunction is linked to Spinocerebellar Ataxia Type 3 pathophysiology
Hua, L.; Xu, M.; Zhang, L.; Gao, F.; Zeng, X.; Yang, A.; Luan, J.; Shmuel, A.; Ma, G.; Yuan, Z.
10.1101/2024.04.16.589724 — neuroscience — Posted on 2024-04-20
1781 Effects of Repetitive Mild Traumatic Brain Injury on Corticotropin-Releasing Factor Modulation of Lateral Habenula Excitability and Motivated Behavior
Flerlage, W. J.; Simmons, S. C.; Thomas, E. H.; Gouty, S.; Tsuda, M. C.; Wu, T. J.; Armstrong, R. S.; Cox, B. M.; Nugent, F. S.
10.1101/2024.04.16.589760 — neuroscience — Posted on 2024-04-20
1782 CA1 Engram Cell Dynamics Before and After Learning
Monasterio, A.; Lienkaemper, C.; Coello, S.; Ocker, G. K.; Ramirez, S.; Scott, B. B.
10.1101/2024.04.16.589790 — neuroscience — Posted on 2024-04-20
1783 Eigenmodes of the brain: revisiting connectomics and geometry
Mansour L., S.; Behjat, H.; Van De Ville, D.; Smith, R. E.; Yeo, B. T. T.; Zalesky, A.
10.1101/2024.04.16.589843 — neuroscience — Posted on 2024-04-20
1785 Dense Investigation of Variability in Affect (DIVA): A Neuroimaging Study of Premenopausal Female Participants
Bottenhorn, K. L.; Salo, T.; Peraza, J. A.; Riedel, M. C.; Flannery, J. S.; Kimbler, A.; Toll, A.; Suarez, D.; Cruz, F. M.; Zagales, I.; Caldes, N.; Dolan, O.; Zagales, R.; Sutherland, M.; Laird, R. W.; Laird, A. R.
10.1101/2024.04.16.589598 — neuroscience — Posted on 2024-04-20
1791 Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis
Khan, M.; Hunt, D. M.; Singha, B.; Kapoor, Y.; Singh, N.; Prasad, D. V. S.; Dharmarajan, S.; Sowpati, D. T.; de Carvalho, L.; Nandicoori, V. K.
10.1101/2023.10.03.560673 — microbiology — Posted on 2024-04-20
1797 Tissue factor-dependent colitogenic CD4+ T cell thrombogenicity is regulated by activated protein C signalling.
Leon, G.; Klavina, P. A.; Rehill, A. M.; Chomanahalli Basavarajappa, S.; O'Donnell, J. S.; Hussey, S.; Walsh, P. T.; Preston, R. J. S.
10.1101/2024.04.16.589774 — immunology — Posted on 2024-04-20
1799 Genetic context modulates aging and degeneration in the murine retina
MacLean, M.; Marola, O. J.; Diemler, C. A.; Cossette, T. L.; Hewes, A. A.; Reagan, A. M.; Skelly, D. A.; Howell, G. R.
10.1101/2024.04.16.589625 — neuroscience — Posted on 2024-04-20
1801 Common viral infections inhibit egg laying in honey bee queens and are linked to premature supersedure
Chapman, A. A.; McAfee, A.; Tarpy, D. R.; Fine, J.; Rempel, Z.; Peters, K.; Currie, R.; Foster, L.
10.1101/2024.04.16.589807 — zoology — Posted on 2024-04-20
1803 Cell Targeting and Adjuvant Activity of Dietary Titanium Dioxide
Wills, J. W.; Dabrowska, A.; Robertson, J.; Miniter, M.; Riedle, S.; Summers, H.; Hewitt, R.; Fathima, A.; Barreto da Silva, A.; Bastos, C.; Micklethwaite, S.; Keita, A.; Soderholm, J.; Roy, N.; Otter, D.; Jugdaohsingh, R.; Mastroeni, P.; Brown, A. P.; Rees, P.; Powell, J. J.
10.1101/2024.04.16.589772 — pharmacology and toxicology — Posted on 2024-04-20
1804 PERK inhibition in zebrafish mimics human Wolcott-Rallison syndrome phenotypes
Almeida, L. M.; Lima, L. P.; Oliveira, N. A. S.; Silva, R. F. O.; Sousa, B.; Bessa, J.; Pinho, B. R.; Oliveira, J. M. A.
10.1101/2024.04.16.589737 — pharmacology and toxicology — Posted on 2024-04-20
1805 Repair of leukemia-associated single nucleotide variants via interallelic gene conversion
Silver, A. J.; Brown, D. J.; Olmstead, S. D.; Watke, J. M.; Gorska, A. E.; Tanner, L.; Ramsey, H. E.; Savona, M. R.
10.1101/2024.04.16.587991 — cancer biology — Posted on 2024-04-20
1809 Healthy carriage of Salmonella within cattle lymph nodes is a key source of ground beef contamination with strains of clinical significance
Delgado-Suarez, E. J.; Garcia-Meneses, A. V.; Ponce-Hernandez, E. A.; Hernandez-Perez, C. F.; Rubio-Lozano, M. S.; Ballesteros-Nova, N. E.; Soberanis-Ramos, O.
10.1101/2024.04.16.589703 — genomics — Posted on 2024-04-20
1810 Cytosolic Ribosomal Protein Haploinsufficiency affects Mitochondrial Morphology and Respiration
Surya, A.; Bolton, B. M.; Rothe, R.; Mejia-Trujillo, R.; Zhao, Q.; Leonita, A.; Liu, Y.; Rangan, R.; Gorusu, Y.; Nguyen, P.; Cenik, C.; Sarinay Cenik, E.
10.1101/2024.04.16.589775 — genetics — Posted on 2024-04-20
1815 Pervasive gene flow despite strong and varied reproductive barriers in swordtails
Aguillon, S. M.; Haase Cox, S. K.; Langdon, Q. K.; Gunn, T. R.; Baczenas, J. J.; Banerjee, S. M.; Donny, A. E.; Moran, B. M.; Gutierrez-Rodriguez, C.; Rios-Cardenas, O.; Morris, M. R.; Powell, D. L.; Schumer, M.
10.1101/2024.04.16.589374 — evolutionary biology — Posted on 2024-04-20
1817 Global patterns in the evolutionary relations between seed mass and germination traits
Maleki, K.; Vandelook, F.; Saatkamp, A.; Maleki, K.; Heshmati, S.; Soltani, E.
10.1101/2024.04.16.589747 — ecology — Posted on 2024-04-20
1818 Breaking out of the cell cycle: Including quiescence in cell cycle classification
O'Connor, S. A.; Garcia, L.; Patel, A. P.; Hugnot, J.-P.; PADDISON, P.; Plaisier, C. L.
10.1101/2024.04.16.589816 — cell biology — Posted on 2024-04-20
1819 Loss of circulating CD8α+ NK cells during human Mycobacterium tuberculosis infection
Mehanna, N.; Pradhan, A.; Kaur, R.; Kontopoulos, T.; Rosati, B.; Carlson, D.; Cheung, N.-K.; Xu, H.; Bean, J.; Hsu, K.; Le Luduec, J.-B.; Vorkas, C. K.
10.1101/2024.04.16.588542 — immunology — Posted on 2024-04-20
1822 Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition
Funk, C. M.; Ehlers, A.; Orth, M. F.; Aljakouch, K.; Li, J.; Hoelting, T. L. B.; Will, R.; Ceranski, A. K.; Willis, F.; Vinca, E.; Ohmura, S.; Imle, R.; Siebenlist, J.; Yershova, A.; Knott, M. M. L.; Zahnow, F.; Sastre, A.; Alonso, J.; Sahm, F.; Loboda, A.; Peterziel, H.; Schneider, M.; Banito, A.; Leprivier, G.; Hartmann, W.; Dirksen, U.; Witt, O.; Oehme, I.; Pfister, S. M.; Romero-Perez, L.; Krijgsveld, J.; Cidre-Aranaz, F.; Gruenewald, T. G. P.; Musa, J.
10.1101/2022.12.11.519935 — cancer biology — Posted on 2024-04-20
1823 Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion
gadal, s.; Boyer, J. A.; Roy, S. F.; Outmezguine, N. A.; Sharma, M.; Li, H.; Fan, N.; Chan, E.; Romin, Y.; Barlas, A.; Chang, Q.; Pancholi, P.; Timaul, N. M.; Overholtzer, M.; Yaeger, R.; Todorova, K. M.; Stanchina, E. d.; Bosenberg, M.; Rosen, N.
10.1101/2023.11.21.568071 — cancer biology — Posted on 2024-04-20
1826 Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
Ng, T. L. C.; Hoare, M. P.; Maristany, M. J.; Wilde, E. J.; Sneideris, T.; Huertas, J.; Agbetiameh, B. K.; Furukawa, M.; Joseph, J. A.; Knowles, T. P. J.; Collepardo-Guevara, R.; Itzhaki, L. S.; Kumita, J. R.
10.1101/2024.04.16.589709 — biophysics — Posted on 2024-04-20
1828 Assessment of the Degree of Coincidence between Differentially Expressed Genes in Pancreatic Cancer with and without CAR T Cell treatment.
Luna-Alvear, A. E.; Suarez-Gomez, D.; Sanchez-Castro, A. A.; Rentas-Echeverria, A. C.; Cabrera-Rios, M.; Isaza, C. E.
10.1101/2024.04.15.589636 — bioinformatics — Posted on 2024-04-20
1829 Bessel Beam Optical Coherence Microscopy Enables Multiscale Assessment of Cerebrovascular Network Morphology and Function
Glandorf, L.; Wittmann, B.; Droux, J.; Glueck, C.; Weber, B.; Wegener, S.; EL AMKI, M.; Leitgeb, R.; Menze, B.; Razansky, D.
10.1101/2024.04.16.589730 — bioengineering — Posted on 2024-04-20
1830 Phylogenomic reconstruction of Cryptosporidium spp. captured directly from clinical samples reveals extensive genetic diversity
Khan, A.; Alves-Ferreira, E. V. C.; Vogel, H.; Botchie, S.; Ayi, I.; Pawlowic, M.; Robinson, G.; Chalmers, R. M.; Lorenzi, H.; Grigg, M. E.
10.1101/2024.04.17.589752 — genomics — Posted on 2024-04-20
1836 Evaluation of multi-peptide sequences identified in silico for the serological diagnosis of Vector-Borne Diseases
Pena-Bates, C. A.; Lugo-Caballero, C. I.; Pavia-Ruz, N. I.; Noh-Pech, H. R.; Omodior, O.; Puerto-Manzano, F. I.; Dzul-Rosado, K. R.
10.1101/2024.04.16.589708 — ecology — Posted on 2024-04-20
1837 Colonization of Anopheles coustani, a neglected malaria vector in Madagascar
Andrianinarivomanana, T. M.; Randrianaivo, F. T.; Andriamiarimanana, M. R.; Razafimamonjy, M. R.; Velonirina, H. J. S.; Puchot, N.; Girod, R.; Bourgouin, C.
10.1101/2024.04.16.589755 — ecology — Posted on 2024-04-20
1839 Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts
Glauninger, H.; Bard, J. A. M.; Wong Hickernell, C. J.; Airoldi, E. M.; Li, W.; Singer, R. H.; Paul, S.; Fei, J.; Sosnick, T. R.; Wallace, E. W. J.; Drummond, D. A.
10.1101/2024.04.15.589678 — cell biology — Posted on 2024-04-20
1841 Lipid transfer proteins and a PI 4-kinase initiate nuclearphosphoinositide signaling
Carrillo, N. D.; Chen, M.; Wen, T.; Awasthi, P.; Wolfe, T. J.; Cryns, V. L.; Anderson, R. A.
10.1101/2023.05.08.539894 — cell biology — Posted on 2024-04-20
1842 Rules of engagement for condensins and cohesins guide mitotic chromosome formation
Samejima, K.; Gibcus, J. H.; Abraham, S.; Cisneros-Soberanis, F.; Samejima, I.; Beckett, A. J.; Pucekova, N.; Abad, M. A.; Medina-Pritchard, B.; Paulson, J. R.; Xie, L.; Jeyaprakash, A. A.; Prior, I. A.; Mirny, L. A.; Dekker, J.; Goloborodko, A.; Earnshaw, W. C.
10.1101/2024.04.18.590027 — molecular biology — Posted on 2024-04-20
1844 Evidence for the key roles of the Pseudomonas syringae mobilome in shaping biotic interactions
Holtappels, D.; Rickus, G. J. E.; Morgan, T.; de Rezende, R. R.; Koskella, B.; Alfenas-Zerbini, P.
10.1101/2024.03.19.585818 — microbiology — Posted on 2024-04-20
1845 Engineering a Sinorhizobium meliloti chassis with monopartite, single replicon genome configuration
Wagner, M.; Döhlemann, J.; Geisel, D.; Sobetzko, P.; Serrania, J.; Lenz, P.; Becker, A.
10.1101/2022.05.23.493018 — microbiology — Posted on 2024-04-20
1846 Heterogeneity of foam cell biogenesis across diseases
Guerrini, V.; Prideaux, B.; Khan, R.; Subbian, S.; Wang, Y.; Sadimin, E.; Pawar, S.; Ukey, R.; Singer, E. A.; Xue, C.; Gennaro, M. L.
10.1101/2023.06.08.542766 — immunology — Posted on 2024-04-20
1848 The Switchmaze: an open-design device for measuring motivation and drive switching in mice
Hartmann, C.; Mahajan, A.; Borges, V.; Razenberg, L.; Thoennes, Y.; Karnani, M. M.
10.1101/2024.01.31.578188 — neuroscience — Posted on 2024-04-20
1850 Neural activity ramps in frontal cortex signal extended motivation during learning
Regalado, J. M.; Corredera Asensio, A.; Haunold, T.; Toader, A. C.; Li, Y. R.; Neal, L. A.; Rajasethupathy, P.
10.1101/2023.10.15.562395 — neuroscience — Posted on 2024-04-20
1852 Feeding Behavior Modifies the Circadian Variation in RR and QT intervals by Distinct Mechanisms in Mice
Ono, M.; Burgess, D.; Johnson, S. R.; Elayi, C. S.; Esser, K. A.; Seward, T. S.; Boychuk, C. A.; Stalcup, R. A.; Carreno, A. P.; Prabhat, A.; Schroder, E.; Delisle, B. P.
10.1101/2023.11.02.565372 — physiology — Posted on 2024-04-20
1855 NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors
Hill, C.; Indeglia, A.; Picone, F.; Murphy, M.; Cipriano, C.; Maki, R. G.; Gardini, A.
10.1101/2024.04.15.589533 — cancer biology — Posted on 2024-04-20
1856 Patient-derived lymphomoids preserve the tumor architecture and allow to assess response to therapies in lymphoma
Santamaria-Martinez, A.; Epiney, J.; Srivastava, D.; Tavernari, D.; Varrone, M.; Milowich, D.; Letovanec, I.; Krueger, T.; Duran, R.; Ciriello, G.; Cairoli, A.; Oricchio, E.
10.1101/2024.04.15.589480 — cancer biology — Posted on 2024-04-20
1861 FOXA1 is required for ErbB2 expression and luminal differentiation in HER2-positive breast cancer
Jeong, J.; Lee, J.; Lim, J.; Shin, J.; Yoo, K.; Kim, J.; Tanaka, Y.; Tae, H. S.; Kim, L. K.; Park, I.-H.; Wysolmerski, J.; choi, j.
10.1101/2024.04.16.589460 — cancer biology — Posted on 2024-04-20
1862 High-Throughput DNA melt measurements enable improved models of DNA folding thermodynamics
Ke, Y.; Sharma, E.; Wayment-Steele, H. K.; Becker, W. R.; Ho, A.; Marklund, E.; Greenleaf, W. J.
10.1101/2024.01.08.574731 — biophysics — Posted on 2024-04-20
1863 Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer
Kim, N.; Park, S.; Jo, A.; Eum, H. H.; Kim, H. K.; Lee, K.; Cho, J. H.; Ku, B. M.; Jung, H. A.; Sun, J.-M.; Lee, S.-H.; Ahn, J. S.; Lee, J.-I.; Choi, J. W.; Jeong, D.; Na, M.; Kang, H.; Kim, J. Y.; Choi, J. K.; Lee, H.-O.; Ahn, M.-J.
10.1101/2024.04.15.589544 — bioinformatics — Posted on 2024-04-20
1864 Designing molecular RNA switches with Restricted Boltzmann machines
Fernandez-de-Cossio-Diaz, J.; Hardouin, P.; Lyonnet du Moutier, F.-X.; Di Gioacchino, A.; Marchand, B.; Ponty, Y.; Sargueil, B.; Monasson, R.; Cocco, S.
10.1101/2023.05.10.540155 — bioinformatics — Posted on 2024-04-20
1865 GFPrint™: A MACHINE LEARNING TOOL FOR TRANSFORMING GENETIC DATA INTO CLINICAL INSIGHTS
Sanz-Martin, G.; Migliore, D. P.; Gomez del Campo, P.; del Castillo-Izquierdo, J.; Dominguez, J. M.
10.1101/2024.03.08.584090 — bioinformatics — Posted on 2024-04-20
1869 Fetal Kidney Transplantation for In Utero Fetuses
Morimoto, K.; Yamanaka, S.; Matsui, K.; Kinoshita, Y.; Inage, Y.; Yamamoto, S.; Koda, N.; Matsumoto, N.; Saito, Y.; Takamura, T.; Fujimoto, T.; Fukunaga, S.; Tajiri, S.; Matsumoto, K.; Ozawa, K.; Wada, S.; Kobayashi, E.; Yokoo, T.
10.1101/2024.04.15.589452 — bioengineering — Posted on 2024-04-20
1870 Effect of homotypic vs. heterotypic interactions on the cellular uptake of extracellular vesicles
Jhaveri, J. R.; Khare, P.; Pinky, P. P.; Kamte, Y. S.; Chandwani, M. N.; Milosevic, J.; Abraham, N.; Dave, K. M.; Zheng, S.-y.; O'Donnell, L.; Manickam, D. S.
10.1101/2023.10.23.563628 — bioengineering — Posted on 2024-04-20
1872 Adaptation across a precipitation gradient from niche center to niche edge
vanDeurs, S.; Reutimann, O.; Luqman, H.; Lifshitz, D.; Mayzlish Gati, E.; Alexander, J.; Fior, S.
10.1101/2024.04.15.589238 — genomics — Posted on 2024-04-20
1875 Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize
Engelhorn, J.; Snodgrass, S. J.; Kok, A.; Seetharam, A. S.; Schneider, M.; Kiwit, T.; Singh, A.; Banf, M.; Khaipho-Burch, M.; Runcie, D. E.; Sanchez-Camargo, V. A.; Torres-Rodriguez, J. V.; Sun, G.; Stam, M.; Fiorani, F.; Beier, S.; Schnable, J. C.; Bass, H. W.; Hufford, M. B.; Stich, B.; Frommer, W. B.; Ross-Ibarra, J.; Hartwig, T.
10.1101/2023.08.08.551183 — genomics — Posted on 2024-04-20
1881 Automated detection of Bornean white-bearded gibbon (Hylobates albibarbis) vocalisations using an open-source framework for deep learning
Owens, A. F.; Hockings, K. J.; Imron, M. A.; Madhusudhana, S.; Niun, M. A.; Setia, T. M.; Sharma, M. D.; Soebagio, S. M.; Van Veen, F. J. F.; Erb, W. M.
10.1101/2024.04.15.589517 — ecology — Posted on 2024-04-20
1888 Timing-dependent effects of elevated maternal glucocorticoids on offspring brain gene expression in a wild small mammal
Westrick, S. E.; Fischer, E. K.; van Kesteren, F.; Boutin, S.; Lane, J. E.; McAdam, A. G.; Dantzer, B.
10.1101/2024.04.19.590319 — ecology — Posted on 2024-04-19
1892 Machine learning methods for predicting guide RNA effects in CRISPR epigenome editing experiments
Mu, W.; Luo, T.; Barrera, A.; Bounds, L. R.; Klann, T. S.; Weele, M. t.; Bryois, J.; Crawford, G. E.; Sullivan, P. F. E.; Gersbach, C. A.; Love, M. I.; Li, Y.
10.1101/2024.04.18.590188 — bioinformatics — Posted on 2024-04-19
1893 Proteomic Discovery of RNA-Protein Molecular Clamps Using a Thermal Shift Assay with ATP and RNA (TSAR)
Goldstein, S. I.; Fan, A. C.; Wang, Z.; Naineni, S. K.; Lengqvist, J.; Chernobrovkin, A.; Garcia-Gutierrez, S. B.; Cencic, R.; Patel, K.; Huang, S.; Brown, L. E.; Emili, A.; Porco, J. A.
10.1101/2024.04.19.590252 — biochemistry — Posted on 2024-04-19
1895 Phase separation of a microtubule plus-end tracking protein into a fluid fractal network
Czub, M.; Uliana, F.; Grubic, T.; Padeste, C.; Rosowski, K. A.; Dufresne, E. R.; Menzel, A.; Vakonakis, I.; Gasser, U.; Steinmetz, M. O.
10.1101/2024.04.19.590270 — biochemistry — Posted on 2024-04-19
1896 Parasite genetic variation and systemic immune responses are not associated with different clinical presentations of cutaneous leishmaniasis caused by Leishmania aethiopica
Yizengaw, E.; Takele, Y.; Franssen, S. U.; Gashaw, B.; Yimer, M.; Adem, E.; Nibret, E.; Yismaw, G.; Cruz Cervera, E.; Ejigu, K.; Tamiru, D.; Munshea, A.; Muller, I.; Weller, R.; Cotton, J.; Kropf, P.
10.1101/2024.04.19.590259 — genomics — Posted on 2024-04-19
1898 Aggregation of an FG nucleoporin under crowded conditions
Maguire, L.; Reskin, S.; Wall, K. P.; Arroyo, E.; Marchando, P.; Whited, A. M.; Erbse, A.; Whitten, S. T.; Hough, L. E.
10.1101/2024.04.15.589310 — biophysics — Posted on 2024-04-19
1900 A New Large-Scale Extracellular Vesicle Production Strategy for Biomedical Drug Development
Yang, S.; Zhang, L.; Zhou, X.; Peng, X.; Zhang, X.; Wang, W.; Zhao, J.; He, X.; Xu, K.
10.1101/2024.04.15.589541 — bioengineering — Posted on 2024-04-19
1904 Large-scale single-virus genomics uncovers hidden diversity of river water viruses and diversified gene profiles
Nishikawa, Y.; Wagatsuma, R.; Tsukada, Y.; Chia-ling, L.; Chijiiwa, R.; Hosokawa, M.; Takeyama, H.
10.1101/2024.04.18.589877 — genomics — Posted on 2024-04-19
1905 Wampee chromosome-level reference genome elucidates fruit sugar-acid metabolism
Chen, H.; Wang, J.; Wang, X.; Peng, C.; Chang, X.; Chen, Z.; Yang, B.; Wang, X.; Qiu, J.; Guo, L.; Lu, Y.
10.1101/2024.04.16.589530 — genomics — Posted on 2024-04-19
1906 DNA virus infections shape transposable elements activity in vitro and in vivo
Tan, J.; Franke, V.; Neugebauer, E.; Lagisquet, J.; Kuderna, A. K.; Walter, S.; Landthaler, M.; Ensser, A.; Stamminger, T.; Gramberg, T.; Akalin, A.; Wyler, E.; Full, F.
10.1101/2024.04.18.589901 — genomics — Posted on 2024-04-19
1907 Massively parallel jumping assay decodes Alu retrotransposition activity
Ahituv, N.; Matharu, N.; Zhao, J.; Sohota, A.; Deng, L.; Hung, Y.; Li, Z.; Sims, J.; Rattanasopha, S.; Meyer, J.; Carbone, L.; Kircher, M.
10.1101/2024.04.16.589814 — genomics — Posted on 2024-04-19
1908 Functional and antigenic landscape of the Nipah virus receptor binding protein
Larsen, B. B.; McMahon, T.; Brown, J. T.; Wang, Z.; Radford, C. E.; Crowe, J. E.; Veesler, D.; Bloom, J. D.
10.1101/2024.04.17.589977 — evolutionary biology — Posted on 2024-04-19
1909 Whole-genome duplication in the Multicellularity Long Term Evolution Experiment
Tong, K.; Datta, S.; Cheng, V.; Haas, D. J.; Gourisetti, S.; Yopp, H. L.; Day, T. C.; Lac, D. T.; Conlin, P. L.; Bozdag, G. O.; Ratcliff, W. C.
10.1101/2024.04.18.588554 — evolutionary biology — Posted on 2024-04-19
1910 Palaeoproteomic identification of a whale bone tool from Bronze Age Heiloo, the Netherlands
Dekker, J. A. A.; Mylopotamitaki, D.; Verbaas, A.; Sinet-Mathiot, V.; Presslee, S.; McCarthy, M. L.; Olsen, M. T.; Olsen, J. V.; van den Hurk, Y.; Brattinga, J.; Welker, F.
10.1101/2024.04.15.589626 — evolutionary biology — Posted on 2024-04-19
1912 Amyloid-beta increases MBP and MOBP translation in oligodendrocytes through dysregulation of hnRNP A2 dependent RNA dynamics
Gaminde-Blasco, A.; Senovilla-Ganzo, R.; Balantzategi, U.; Garcia-Moreno, F.; Matute, C.; Baleriola, J.; Alberdi, E.
10.1101/2024.04.19.590214 — molecular biology — Posted on 2024-04-19
1913 Novel multiparametric bulk and single EV pipeline for adipose cell-specific biomarker discovery in paired human biospecimens
Palacia, P. L.; Greenwald, J.; Nguyen, K. T. K.; Shantaram, D.; Butsch, B.; Kim, Y.; Hade, M. D.; Noria, S.; Brethauer, S.; Needleman, B.; Wysocki, V.; Hsueh, W.; Reategui, E.; Magana, S. M.
10.1101/2024.04.18.590172 — molecular biology — Posted on 2024-04-19
1915 Activation of bradykinin receptor B1 promotes desensitization of CXCR2 in neutrophils during severe sepsis and contributes to disease progression in mice.
Souza, D. G.; Arifa, R. D. d. N.; Mascarenhas, C. B. R.; Rossi, L. C. R.; Silva, M. E. F.; Resende, B.; Tavares, L. D.; Reis, A. C.; Pinho, V.; Amaral, F. A.; Fagundes, C. T.; Lima, C. X.; Teixeira, M. M.
10.1101/2024.04.19.590213 — microbiology — Posted on 2024-04-19
1917 Flumequine, a fluoroquinolone in disguise
Swinkels, A.; Fischer, E.; Korving, L.; Chirstodoulou, R.; Wagenaar, J. A.; Zomer, A. L.
10.1101/2024.04.19.590246 — microbiology — Posted on 2024-04-19
1920 Source-to-Tap Investigation of the Occurrence of Nontuberculous Mycobacteria in a Full-Scale Chloraminated Drinking Water System
Dowdell, K. S.; Potgieter, S. C.; Olsen, K.; Lee, S.; Vedrin, M.; Caverly, L. J.; LiPuma, J. J.; Raskin, L.
10.1101/2024.04.18.590135 — microbiology — Posted on 2024-04-19
1921 A conserved genetic basis for commensal-host specificity through live imaging of colonization dynamics
Gutierrez-Garcia, K.; Aumiller, K.; Dodge, R.; Obadia, B.; Deng, A.; Agrawal, S.; Yuan, X.; Wolff, R.; Garud, N.; Ludington, W. B.
10.1101/2024.04.19.590229 — microbiology — Posted on 2024-04-19
1922 Jumbo phages possess independent synthesis and utilization systems of NAD+
Li, C.; Liu, K.; Gu, C.; Li, M.; Zhou, P.; Chen, L.; Sun, S.; Li, X.; Wang, L.; Ni, W.; Li, M.; Hu, S.
10.1101/2024.04.18.590177 — microbiology — Posted on 2024-04-19
1923 Long-term fasting remodels gut microbial metabolism and host metabolism
Ducarmon, Q. R.; Grundler, F.; Giannopoulou, C.; Loume, A.; Karcher, N.; Larralde, M.; Romano, S. R.; MacArthur, M.; Mitchell, S. J.; Wilhelmi de Toledo, F.; Zeller, G.; Mesnage, R.
10.1101/2024.04.19.590209 — microbiology — Posted on 2024-04-19
1925 Optimization of an adeno-associated viral vector for keratinocytes in vitro and in vivo
Shen, Q.; Suga, S.; Moriwaki, Y.; Zening, D.; Aizawa, E.; Okazaki, M.; Izpisua Belmonte, J. C.; Hirabayashi, Y.; Suzuki, K.; Kurita, M.
10.1101/2024.04.15.589645 — bioengineering — Posted on 2024-04-19
1929 A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes
Bykov, Y. S.; Zuttion, S.; Senger, B.; Klein, O.; Asraf, Y.; Meyer, H.; Becker, H. D.; Kucharczyk, R.; Schuldiner, M.
10.1101/2024.04.17.589881 — cell biology — Posted on 2024-04-19
1930 PAbFold: Linear Antibody Epitope Prediction using AlphaFold2
DeRoo, J.; Terry, J. S.; Zhao, N.; Stasevich, T. J.; Snow, C.; Geiss, B. J.
10.1101/2024.04.19.590298 — molecular biology — Posted on 2024-04-19
1935 Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.
Siegel, D. S.; Hui, H. C.; Pitts, J.; Vermillion, M. S.; Ishida, K.; Rautiola, D.; Keeney, M.; Irshad, H.; Zhang, L.; Chun, K.; Chin, G.; Goyal, B.; Doerffler, E.; Yang, H.; Clarke, M. O.; Palmiotti, C.; Vijjapurapu, A.; Riola, N. C.; Stray, K.; Murakami, E.; Ma, B.; Wang, T.; Zhao, X.; Xu, Y.; Lee, G.; Marchand, B.; Seung, M.; Nayak, A.; Tomkinson, A.; Kadrichu, N.; Ellis, S.; Barauskas, O.; Feng, J. Y.; Perry, J. K.; Perron, M.; Bilello, J.; Kuehl, P. J.; Subramanian, R.; Cihlar, T.; Mackman, R. L.
10.1101/2024.04.17.589937 — biochemistry — Posted on 2024-04-19
1936 Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L
Zhu, K.; Chatrin, C.; Suskiewicz, M.; Aucagne, V.; Ahel, D.; Ahel, I.
10.1101/2024.04.19.590267 — biochemistry — Posted on 2024-04-19
1939 Receptor activity modifying protein modulation of parathyroid hormone-1 receptor function and signalling.
Avgoustou, P.; Jailani, A. B.; Desai, A. J.; Roberts, D. J.; Stothard, G. W.; Lilley, E. R.; Richards, G. O.; Skerry, T. M.
10.1101/2024.04.16.588673 — pharmacology and toxicology — Posted on 2024-04-19
1940 An unsupervised map of excitatory neurons' dendritic morphology in the mouse visual cortex
Weis, M. A.; Papadopoulos, S.; Hansel, L.; Lueddecke, T.; Celii, B.; Fahey, P. G.; Wang, E. Y.; Bae, J. A.; Bodor, A. L.; Brittain, D.; Buchanan, J.; Bumbarger, D. J.; Castro, M. A.; Collman, F.; da Costa, N. M.; Dorkenwald, S.; Elabbady, L.; Halageri, A.; Jia, Z.; Jordan, C.; Kapner, D.; Kemnitz, N.; Kinn, S.; Lee, K.; Li, K.; Lu, R.; Macrina, T.; Mahalingam, G.; Mitchell, E.; Mondal, S. S.; Mu, S.; Nehoran, B.; Popovych, S.; Reid, R. C.; Schneider-Mizell, C. M.; Seung, H. S.; Silversmith, W.; Takeno, M.; Torres, R.; Turner, N. L.; Wong, W.; Wu, J.; Yin, W.; Yu, S.-c.; Reimer, J.; Berens, P.;
10.1101/2022.12.22.521541 — neuroscience — Posted on 2024-04-19
1941 SuperResNET GUI: model-free single molecule network analysis software achieves molecular resolution of Nup96
Li, Y. L.; Khater, I. M.; Hallgrimson, C.; Cardoen, B.; Wong, T. H.; Hamarneh, G.; Nabi, I. R.
10.1101/2024.03.12.584716 — cell biology — Posted on 2024-04-19
1944 SMPD3 suppresses IDH mutant tumor growth via dual autocrine-paracrine roles
Balakrishnan, A.; Saleh, F.; Adnani, L.; Chinchalongporn, V.; El-Sehemy, A.; Olender, T.; Chen, M. J.; Ahmad, S. T.; Prokopchuk, O.; Vasan, L.; Touahri, Y.; Islam, R.; Sujanthan, S.; Zinyk, D.; Comanita, L. C.; Kan, B.; Fleming, T.; Michael, I. P.; Morshead, C. M.; Leong, H. S.; Okawa, S.; Brand, M.; Wallace, V. A.; Chan, J. A.; Schuurmans, C.
10.1101/2020.07.14.202200 — cancer biology — Posted on 2024-04-19
1946 Does transcriptome of freshly hatched fish larvae describe past or predict future developmental trajectory?
Debernardis, R.; Palinska-Zarska, K.; Judycka, S.; Panda, A.; Jarmolowicz, S.; Jastrzebski, J. P.; de Almeida, T.; Blazejewski, M.; Hliwa, P.; Krejszeff, S.; Zarski, D.
10.1101/2023.10.27.564361 — developmental biology — Posted on 2024-04-19
1949 Magnetomyography: A novel modality for non-invasive muscle sensing
Yun, R.; Gonzalez, G.; Gerrard, I.; Csaky, R.; Dash, D.; Kittle, E.; Deka, N.; Labanowski, D.
10.1101/2024.04.15.588623 — neuroscience — Posted on 2024-04-19
1950 Systems Neuroscience Computing in Python (SyNCoPy): A Python Package for Large-scale Analysis of Electrophysiological Data
Moenke, G.; Schaefer, T.; Parto-Dezfouli, M.; Kajal, D. S.; Fuertinger, S.; Schmiedt, J. T.; Fries, P.
10.1101/2024.04.15.589590 — neuroscience — Posted on 2024-04-19
1955 Genome wide inherited modifications of the tomato epigenome by trans-activated bacterial CG methyltransferase
Kumar, B. K. P.; Beaubiat, S.; Yadav, C. B. Y.; Eshed, R.; Arazi, T.; Sherman, A.; Bouche, N.
10.1101/2024.04.17.589930 — plant biology — Posted on 2024-04-19
1957 Quantifying Leaf Symptoms of Sorghum Charcoal Rot in Images of Field-Grown Plants 9 Using Deep Neural Networks
Gonzalez, E. M.; Zarei, A.; Calleja, S.; Christenson, C.; Rozzi, B.; Demieville, J.; Hu, J.; Eveland, A. L.; Dilkes, B. L.; Barnard, K.; Lyons, E.; Pauli, D.
10.1101/2024.04.17.589978 — plant biology — Posted on 2024-04-19
1962 Identification and characterization of innate immunity in Actinidia melanandra in response to Pseudomonas syringae pv. actinidiae
Hemara, L. M.; Chatterjee, A.; Yeh, S.-M.; Chen, R. K. Y.; Hilario, E.; Le Lievre, L.; Crowhurst, R. N.; Bohne, D.; Arshed, S.; Patterson, H. R.; Barrett-Manako, K.; Thomson, S.; Allan, A. C.; Brendolise, C.; Chagne, D.; Templeton, M. D.; Jayaraman, J.; Tahir, J.
10.1101/2024.04.16.589833 — plant biology — Posted on 2024-04-19
1963 Homeostats - the hidden rulers of ion homeostasis in plants
Dreyer, I.; Hernandez-Rojas, N.; Bolua-Hernandez, Y.; Tapia-Castillo, V. d. l. A.; Astola-Mariscal, S. Z.; Diaz-Pico, E.; Merida-Quesada, F.; Vergara-Valladares, F.; Arrey-Salas, O.; Rubio-Melendez, M. E.; Riedelsberger, J.; Michard, E.
10.1101/2024.04.15.589567 — plant biology — Posted on 2024-04-19
1964 Molecular fingerprints of cell size sensing and mating type differentiation in pennate diatoms
Belisova, D.; Bilcke, G.; Audoor, S.; D'hondt, S.; De Veylder, L.; Vandepoele, K.; Vyverman, W.
10.1101/2024.04.15.589526 — plant biology — Posted on 2024-04-19
1965 A role for root carbonic anhydrase βCA4 in bicarbonate tolerance of Arabidopsis thaliana
Perez-Martin, L.; Almira Casellas, M. J.; Estrela Muriel, L.; Tolra, R.; Rubio, L.; Poschenrieder, C.; Busoms, S.
10.1101/2024.04.18.590072 — plant biology — Posted on 2024-04-19
1968 Proteolytic processing of both RXLR and EER motifs in oomycete effectors
Xu, L.; Wang, S.; Wang, W.; Wang, H.; Welsh, L.; Boevink, P. C.; Whisson, S. C.; Birch, P. R.
10.1101/2024.04.16.589758 — plant biology — Posted on 2024-04-19
1969 From raw microalgae to bioplastics: conversion of Chlorella vulgaris starch granules into thermoplastic starch
Six, A.; Dauvillee, D.; Lancelon-Pin, C.; Dimitriades-Lemaire, A.; Compadre, A.; Dubreuil, C.; Alvarez, P.; Sassi, J.-F.; Li-Beisson, Y.; Putaux, J.-L.; Le Moigne, N.; Gatien, F.
10.1101/2024.04.17.589749 — plant biology — Posted on 2024-04-19
1973 Spatio-temporal transformers for decoding neural movement control
Candelori, B.; Bardella, G.; Spinelli, I.; Pani, P.; Ferraina, S.; Scardapane, S.
10.1101/2024.04.15.589534 — animal behavior and cognition — Posted on 2024-04-19
1976 A role for astrocytic miR-129-5p in Frontotemporal Dementia
Kaurani, L.; Pradhan, R.; Schröder, S.; Burkhardt, S.; Schuetz, A.-L.; Krüger, D. M.; Pena, T.; Heutink, P.; Sananbenesi, F.; Fischer, A.
10.1101/2024.04.15.589528 — neuroscience — Posted on 2024-04-19
1977 Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration
Thomsen, M. S.; Kostrikov, S.; Routhe, L. J.; Johnsen, K. B.; Helgudottir, S. S.; Gudbergsson, J. M.; Andresen, T. L.; Moos, T.
10.1101/2024.04.15.589475 — neuroscience — Posted on 2024-04-19
1978 Enteric glia regulate Paneth cell secretion and intestinal microbial ecology
Prochera, A.; Muppirala, A. N.; Kuziel, G. A.; Soualhi, S.; Shepherd, A.; Sun, L.; Issac, B.; Rosenberg, H. J.; Karim, F.; Perez, K.; Smith, K. H.; Archibald, T. H.; Rakoff-Nahoum, S.; Hagen, S. J.; Rao, M.
10.1101/2024.04.15.589545 — neuroscience — Posted on 2024-04-19
1980 Axon demyelination and degeneration in a zebrafishspastizin model of hereditary spastic paraplegia
Garg, V.; Andre, S.; Heyer, L.; Kracht, G.; Ruhwedel, T.; Scholz, P.; Ischebeck, T.; Werner, H. B.; Dullin, C.; Engelmann, J.; Moebius, W.; Goepfert, M.; Dosch, R.; Geurten, B. R. H.
10.1101/2024.04.15.589631 — neuroscience — Posted on 2024-04-19
1982 Prediction of acoustic tinnitus suppression using resting state EEG: An explainable AI approach
Sadeghi Shabestari, P.; Schoisswohl, S.; Wellauer, Z.; Naas, A.; Kleinjung, T.; Schecklmann, M.; Langguth, B.; Neff, P.
10.1101/2024.04.16.589690 — neuroscience — Posted on 2024-04-19
1984 Enhancing Prosthetic Vision by Upgrade of a Subretinal Photovoltaic Implant in situ
Bhuckory, M. B.; Monkongpitukkul, N.; Shin, A.; Kochnev Goldstein, A.; Jensen, N.; Shah, S. V.; Pham-Howard, D.; Butt, E.; Dalal, R.; Galambos, L.; Mathieson, K.; Kamins, T.; Palanker, D.
10.1101/2024.04.15.589465 — neuroscience — Posted on 2024-04-19
1985 Endothelial and neuronal engagement by AAV-BR1 alleviates neurological symptoms and cholesterol deposition in a mouse model of Niemann-Pick type C2
Rasmussen, C. L. M.; Heegaard, C. W.; Thomsen, M. S.; Hede, E.; Laczek, B.; Korbelin, J.; Thomsen, L. B.; Schwaninger, M.; Moos, T.; Burkhart, A.
10.1101/2024.04.15.589486 — neuroscience — Posted on 2024-04-19
1986 Multiscale Detrended Cross-Correlation Coefficient: Estimating Coupling in Nonstationary Neurophysiological Signals
Stylianou, O.; Susi, G. S.; Hoffmann, M.; Suarez-Mendez, I.; Lopez-Sanz, D.; Schirner, M.; Ritter, P.
10.1101/2024.04.16.589689 — neuroscience — Posted on 2024-04-19
1988 Hemispheric difference of adaptation lifetime in human auditory cortex measured with MEG
Dar, A. H.; Haertwich, N.; Hajizadeh, A.; Brosch, M.; Koenig, R.; May, P. J. C.
10.1101/2024.04.16.588236 — neuroscience — Posted on 2024-04-19
1989 Astrocyte Contribution to Brain State-Dependent Neurovascular Coupling
Stelzner, J. A.; Krogsgaard, A.; Kulkoviene, G.; Sperling, L.; Lind, B. L.
10.1101/2024.04.16.589720 — neuroscience — Posted on 2024-04-19
1993 Unexpected delayed incursion of highly pathogenic avian influenza H5N1 (clade 2.3.4.4b) in the Antarctic region
Lisovski, S.; Gunther, A.; Dewar, M.; Anley, D.; Aldunate, F.; Arce, R.; Ballard, G.; Bauer, S.; Belliure, J.; Banyard, A. C.; Boulinier, T.; Bennison, A.; Braun, C.; Cary, C.; Catry, P.; Clessin, A.; Connan, M.; Correia, E.; Cox, A.; Christina, J.; Elrod, M.; Emerit, J.; Ferreiro, I.; Fowler, Z.; Gamble, A.; Granadeiro, J. P.; Hurtado, J.; Jongsomjit, D.; Kuepfer, A.; Lesage, C.; Lejeune, M.; Lescroel, A.; Li, A.; McDonald, I. R.; Menendez-Blazquez, J.; Morandini, V.; Moratorio, G.; Militao, T.; Moreno, P.; Perbolianachis, P.; Pennycook, J.; Sander, M. M.; Schmidt, A. E.; Smyth, L.; Soutullo,
10.1101/2023.10.24.563692 — microbiology — Posted on 2024-04-19
1994 Genotypic Characterization and Antimicrobial Susceptibility of Human Campylobacter jejuni Isolates in Southern Spain
Fernandez-Palacios, P.; Galan-Sanchez, F.; Casimiro-Soriguer, C. S.; Jurado-Tarifa, E.; Arroyo, F.; Lara, M.; Chaves, J. A.; Dopazo, J.; Rodriguez-Iglesias, M. A.
10.1101/2024.04.17.589908 — microbiology — Posted on 2024-04-19
1995 Human natural killer cells can activate NLRP1 and NLRP3 inflammasomes and drives pyroptosis
Astorga-Gamaza, A.; Muela-Zarzuela, I.; Suarez-Rivero, J. M.; Lopez-Perez, J.; de la Varga-Martinez, R.; Mazuecos, A.; Cordero, M. D.
10.1101/2024.04.17.589865 — immunology — Posted on 2024-04-19
1996 An Alzheimer's disease-associated common regulatory variant in PTK2B has causal effects on microglial function
Bello, E.; Long, K.; Iwama, S.; Steer, J.; Cooper, S. E.; Alasoo, K.; Kumasaka, N.; Schwartzentruber, J.; Panousis, N. I.; Bassett, A. R.
10.1101/2023.11.04.565613 — neuroscience — Posted on 2024-04-19
1997 Key morphological features of human pyramidal neurons
Benavides Piccione, R.; Blazquez-Llorca, L.; Kastanauskaite, A.; Fernaud-Espinosa, I.; Gonzalez-Tapia, S.; DeFelipe, J.
10.1101/2023.11.10.566540 — neuroscience — Posted on 2024-04-19
2002 Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing
Zhou, J.; Zhao, D.; Li, J.; Kong, D.; Li, X.; Zhang, R.; Liang, Y.; Gao, X.; Qian, Y.; Wang, D.; Chen, J.; Lai, L.; Han, Y.; Li, Z.
10.1101/2024.04.17.589933 — biochemistry — Posted on 2024-04-19
2003 Candidate Denisovan fossils identified through gene regulatory phenotyping
Mishol, N.; Herzlinger, G.; Rak, Y.; Smilansky, U.; Carmel, L.; Gokhman, D.
10.1101/2024.04.18.590145 — genetics — Posted on 2024-04-19
2004 Thermal tolerance of mosquito eggs is associated with urban adaptation and human interactions
Chakraborty, S.; Zigmond, E.; Shah, S.; Sylla, M.; Akorli, J.; Otoo, S.; Rose, N. H.; McBride, C. S.; Armbruster, P. A.; Benoit, J. B.
10.1101/2024.03.22.586322 — ecology — Posted on 2024-04-19
2005 Diversity-disease relationships in natural microscopic nematode communities
van Himbeeck, R.; Sowa, J. N.; Tamim El Jarkass, H.; Wu, W.; Oude Vrielink, J.; Riksen, J. A. G.; Reinke, A.; van Sluijs, L.
10.1101/2023.12.08.570776 — ecology — Posted on 2024-04-19
2006 p53 mediated regulation of LINE1 retrotransposon derived R-loops
Paul, P.; Kumar, A.; De, A. K.; Parida, A. S.; Bhadke, G. V.; Khatua, S.; Pattanayak, F.; Tiwari, B.
10.1101/2024.04.12.589154 — cancer biology — Posted on 2024-04-19
2007 Replication poison treated BRCA1-deficient breast cancers are prone to MRE11 over-resection resulting in single strand DNA accumulation and mitotic catastrophe
Tabet, I.; Orhan, E.; Candiello, E.; Fenou, L.; Velazquez, C.; Orsetti, B.; Rodier, G.; Jacot, W.; Ribeyre, C.; Sardet, C.; Theillet, C.
10.1101/2023.10.31.564929 — cancer biology — Posted on 2024-04-19
2009 3D osteocyte lacunar morphometry of human bone biopsies with high resolution microCT: from monoclonal gammopathy to newly diagnosed multiple myeloma
Moreno-Jimenez, I.; Heinig, S.; Heras, U.; Maichl, D. S.; Strifler, S.; Leich, E.; Blouin, S.; Fratzl, P.; Fratzl-Zelman, N.; Jundt, F.; Cipitria, A.
10.1101/2023.07.12.548656 — bioengineering — Posted on 2024-04-19
2012 High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation
Yi, C.; Ma, Y.; Sun, M.; Yuan, X.; Zhu, L.; Sun, J.; Gao, S.; Zhang, M.; Zhang, Y.; Wang, Z.; Tzung, H.; Li, D.; Liu, b.; Fei, P.
10.1101/2023.11.25.568636 — cell biology — Posted on 2024-04-19
2013 Lateral frontoparietal functional connectivity based on individual sulcal morphology
Hakkinen, S.; Voorhies, W. I.; Willbrand, E.; Tsai, Y.-H.; Gagnant, T.; Yao, J. K.; Weiner, K. S.; Bunge, S.
10.1101/2024.04.18.590165 — neuroscience — Posted on 2024-04-18
2017 Early-life scarcity adversity biases behavioral development toward a bipolar-like phenotype in mice heterozygous for CNTNAP2
Chelini, G.; Fortunato-Asquini, T.; Cerilli, E.; Monsorno, K.; Catena, B.; Dall'O', G. M.; Paolicelli, R. C.; Bozzi, Y.
10.1101/2024.04.18.589746 — neuroscience — Posted on 2024-04-18
2020 Candidate Denisovan fossils identified through gene regulatory phenotyping
Mishol, N.; Herzlinger, G.; Rak, Y.; Smilansky, U.; Carmel, L.; Gokhman, D.
10.1101/2024.04.18.590145 — genetics — Posted on 2024-04-18
2025 Mechanical loading reveals an intrinsic cardiomyocyte stiffness contribution to diastolic dysfunction in murine cardiometabolic disease
Janssens, J. V.; Raaijmakers, A. J. A.; Koutsifeli, P.; Weeks, K. L.; Bell, J. R.; Van Eyk, J. E.; Curl, C. L.; Mellor, K. M.; Delbridge, L. M. D.
10.1101/2024.02.21.581448 — physiology — Posted on 2024-04-18
2026 Protein Translation Dysregulation and Immune Cell Evasion Define Metastatic Clones in HPV-related Cancer of the Oropharynx
Chin, V.; Muskovic, W.; McCloy, R. A.; Neavin, D.; Alquicira, J.; Arora, H.; Senabouth, A.; Keith, P.; Spenceley, E.; Murphy, A.; Kaczorowski, D.; Floros, P.; Earls, P.; Leavers, B.; Crawford, J.; Gallaghar, R.; Powell, J.
10.1101/2024.04.15.589624 — cancer biology — Posted on 2024-04-18
2034 De novo design of protein minibinder agonists of TLR3
Adams, C. S.; Kim, H.; Burtner, A. E.; Lee, D. S.; Dobbins, C.; Criswell, C.; Coventry, B.; Kim, H. M.; King, N. P.
10.1101/2024.04.17.589973 — biochemistry — Posted on 2024-04-18
2035 SLC17 transporters mediate renal excretion of Lac-Phe in mice and humans
Li, V. L.; Xiao, S.; Schlosser, P.; Scherer, N.; Wiggenhorn, A. L.; Spaas, J.; Tung, A. S.-H.; Karoly, E. D.; Kottgen, A.; Long, J. Z.
10.1101/2024.04.18.589815 — biochemistry — Posted on 2024-04-18
2036 Delineation of the Complete Reaction Cycle of a Natural Diels-Alderase
Maschio, L.; Back, C. R.; Alnawah, J.; Bowen, J. I.; Johns, S. T.; Mbatha, S. Z.; Han, L.-C.; Lees, N. R.; Zorn, K.; Stach, J. E. M.; Hayes, M. A.; van der Kamp, M. W.; Pudney, C. R.; Burston, S. G.; Willis, C. L.; Race, P. R.
10.1101/2024.04.18.590041 — biochemistry — Posted on 2024-04-18
2037 VASP phase separation with priming proteins of fast endophilin mediated endocytosis modulates actin polymerization
Narayan, K. B.; James, H. P.; Cope, J.; Mondal, S.; Baeyens, L.; Milano, F.; Zheng, J.; Krause, M.; Baumgart, T.
10.1101/2024.03.21.586200 — biochemistry — Posted on 2024-04-18
2039 Phylogenomic reconstruction of Cryptosporidium spp. captured directly from clinical samples reveals extensive genetic diversity
Khan, A.; Alves-Ferreira, E. V. C.; Vogel, H.; Botchie, S.; Ayi, I.; Pawlowic, M.; Robertson, G.; Chalmers, R. M.; Lorenzi, H.; Grigg, M. E.
10.1101/2024.04.17.589752 — genomics — Posted on 2024-04-18
2041 Rules of engagement for condensins and cohesins guide mitotic chromosome formation
Samejima, K.; Gibcus, J. H.; Abraham, S.; Cisneros-Soberanis, F.; Samejima, I.; Beckett, A. J.; Pucekova, N.; Abad, M. A.; Medina-Pritchard, B.; Paulson, J. R.; Xie, L.; Jeyaprakash, A. A.; Prior, I. A.; Mirny, L. A.; Dekker, J.; Goloborodko, A.; Earnshaw, W. C.
10.1101/2024.04.18.590027 — molecular biology — Posted on 2024-04-18
2043 Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30
Huang, P.-C.; Hong, S.; Mimitou, E. P.; Kim, K. P.; Murakami, H.; Keeney, S.
10.1101/2024.04.17.589955 — molecular biology — Posted on 2024-04-18
2044 Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in MDS/AML
Truong, P.; Shen, S.; Joshi, S.; Islam, M. I.; Zhong, L.; Raftery, M.; Afrasiabi, A.; Alinejad-Rokny, H.; Nguyen, M.; Zou, X.; Bhuyan, G. S.; Chowdhury, S.; Ghoudousi, E.; Stonehouse, O.; Mohamed, S.; Toscan, C.; Connerty, P.; Kakadia, P. M.; Bohlander, S. K.; Michie, K.; Larsson, J.; Lock, R. B.; Walkley, C.; Thoms, J. A. I.; Jolly, C. J.; Pimanda, J. E.
10.1101/2024.04.17.589858 — molecular biology — Posted on 2024-04-18
2046 ACE2-independent sarbecovirus cell entry is supported by TMPRSS2-related enzymes and reduces sensitivity to antibody-mediated neutralization
Zhang, L.; Cheng, H.-H.; Krueger, N.; Hoernich, B.; Graichen, L.; Hahn, A. S.; Schulz, S. R.; Jaeck, H.-M.; Stankov, M. V.; Behrens, G. M. N.; Mueller, M. A.; Drosten, C.; Moerer, O.; Winkler, M. S.; Qian, Z.; Poehlmann, S.; Hoffmann, M.
10.1101/2024.04.18.590061 — molecular biology — Posted on 2024-04-18
2047 MePHD1.2 affects the synthesis of cyanogenic glycosides by regulating the transcription of MeCYP79D2 in cassava
Li, M.; Zhao, X.; Li, Y.; Zhao, X.; Mai, W.; Li, Y.; Liang, Q.; Yin, Q.; Wang, W.; Liu, J.; Chen, X.
10.1101/2024.04.18.590026 — molecular biology — Posted on 2024-04-18
2051 Long-term multi-meta-omics resolves the ecophysiological controls of seasonal N2O emissions
Roothans, N.; Pabst, M.; van Diemen, M.; Herrera Mexicano, C.; Zandvoort, M.; Abeel, T.; van Loosdrecht, M. C. M.; Laureni, M.
10.1101/2024.04.17.589950 — microbiology — Posted on 2024-04-18
2054 Rapid mortality in captive bush dogs (Speothos venaticus) caused by influenza A of avian origin (H5N1) at a wildlife collection in the United Kingdom
Falchieri, M.; Reid, S.; Dastderji, A.; Cracknell, J.; Warren, C. J.; Mollett, B.; Peers-Dent, J.; Schlachter, A.-L.; Mcginn, N.; Hepple, R.; Thomas, S.; Ridout, S.; Quayle, J.; Pizzi, R.; Nunez, A.; Byrne, A. M. P.; James, J.; Banyard, A. C.
10.1101/2024.04.18.590032 — microbiology — Posted on 2024-04-18
2055 A natural ANI gap that can define intra-species units of bacteriophages and other viruses
Aldeguer Riquelme, B.; Conrad, R. E.; Anton, J.; Rossello-Mora, R.; Konstantinidis, K. T.
10.1101/2024.04.18.590031 — microbiology — Posted on 2024-04-18
2056 Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1
Dowgier, G.; Hobbs, A.; Greenwood, D.; Shawe-Taylor, M.; Stevenson-Leggett, P.; Bazire, J.; Penn, R.; Harvey, R.; Libri, V.; Kassiotis, G.; Gamblin, S.; Lewis, N. S.; Williams, B.; Swanton, C.; Gandhi, S.; Bauer, D. L.; Carr, E. J.; Wall, E. C.; Wu, M. Y.
10.1101/2024.04.17.589886 — microbiology — Posted on 2024-04-18
2057 Seed tuber microbiome is a predictor of next-season potato vigor
Song, Y.; Atza, E.; Sanchez Gil, J. J.; Akkermans, D.; de Jonge, R.; de Rooij, P. G. H.; Kakembo, D.; Bakker, P. A. H. M.; Pieterse, C. M. J.; Budko, N. V.; Berendsen, R. L.
10.1101/2024.04.18.590071 — microbiology — Posted on 2024-04-18
2058 A generalized framework to identify SARS-CoV-2 broadly neutralizing antibodies
Jian, F.; Wec, A. Z.; Feng, L.; Yu, Y.; Wang, L.; Wang, P.; Yu, L.; Wang, J.; Hou, J.; Berrueta, D. M.; Lee, D.; Speidel, T.; Ma, L.; Kim, T.; Yisimayi, A.; Song, W.; Wang, J.; Liu, L.; Yang, S.; Niu, X.; Xiao, T.; An, R.; Wang, Y.; Shao, F.; Wang, Y.; Pecetta, S.; Wang, X.; Walker, L. M.; Cao, Y.
10.1101/2024.04.16.589454 — immunology — Posted on 2024-04-18
2059 Mesolimbic dopamine ramps reflect environmental timescales
Floeder, J. R.; Jeong, H.; Mohebi, A.; K Namboodiri, V. M.
10.1101/2024.03.27.587103 — neuroscience — Posted on 2024-04-18
2060 Evolution engineering of methylotrophic E. coli enables faster growth than native methylotrophs
Nieh, L.-Y.; Chen, F. Y.- H.; Jung, H.-W.; Su, K.-Y.; Tsuei, C.-Y.; Lin, C. T.; Lee, Y.-Q.; Liao, J. C.
10.1101/2024.04.18.589993 — synthetic biology — Posted on 2024-04-18
2062 Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects
Omo-Lamai, S.; Wang, Y.; Patel, M. N.; Essien, E.-o.; Shen, M.; Majumder, A.; Espy, C.; Wu, J.; Channer, B.; Tobin, M. P.; Murali, S.; Papp, T. E.; Maheshwari, R.; Wang, L.; Chase, L. S.; Zamora, M. E.; Arral, M. L.; Marcos-Contreras, O. A.; Myerson, J. W.; Hunter, C. A.; Tsourkas, A.; Muzykantov, V.; Brodsky, I. E.; Shin, S.; Whitehead, K. A.; Gaskill, P.; Discher, D.; Parhiz, H.; Brenner, J. S.
10.1101/2024.04.16.589801 — bioengineering — Posted on 2024-04-18
2064 Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C)
Dick, J. K.; Sangala, J. A.; Krishna, V. D.; Khaimraj, A.; Hamel, L.; Erickson, S. M.; Hicks, D.; Soigner, Y.; Covill, L. E.; Johnson, A.; Ehrhardt, M. J.; Ernste, K.; Brodin, P.; Koup, R. A.; Khaitan, A.; Baehr, C.; Thielen, B. K.; Henzler, C. M.; Skipper, C.; Miller, J. S.; Bryceson, Y. T.; Wu, J.; John, C. C.; Panoskaltsis-Mortari, A.; Orioles, A.; Steiner, M. E.; Cheeran, M. C.-J.; Pravetoni, M.; Hart, G. T.
10.1101/2024.04.16.589585 — immunology — Posted on 2024-04-18
2065 Molecular basis of proton-sensing by G protein-coupled receptors
Howard, M. K.; Hoppe, N.; Huang, X.-P.; Macdonald, C. B.; Mehrotra, E.; Rockefeller Grimes, P.; Zahm, A. M.; Trinidad, D. D.; English, J. G.; Coyote-Maestas, W.; Manglik, A.
10.1101/2024.04.17.590000 — biochemistry — Posted on 2024-04-18
2066 Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation
Ni, Q.; Ge, Z.; Li, Y.; Shatkin, G.; Fu, J.; Bera, K.; Yang, Y.; Wang, Y.; Sen, A.; Wu, Y.; Vasconcelosi, A. C. N.; Feinberg, A. P.; Konstantopoulos, K.; Sun, S. X.
10.1101/2023.08.31.555808 — biophysics — Posted on 2024-04-18
2069 Simultaneous detection of pathogens and antimicrobial resistance genes with the open source, cloud-based, CZ ID pipeline
Lu, D.; Kalantar, K. L.; Chu, V. T.; Glascock, A. L.; Guerrero, E. S.; Bernick, N.; Butcher, X.; Ewing, K.; Fahsbender, E.; Holmes, O.; Hoops, E.; Jones, A. E.; Lim, R.; McCanny, S.; Reynoso, L.; Rosario, K.; Tang, J.; Valenzuela, O.; Mourani, P. M.; Pickering, A. J.; Raphenya, A. R.; Alcock, B. P.; McArthur, A. G.; Langelier, C. R.
10.1101/2024.04.12.589250 — microbiology — Posted on 2024-04-18
2071 Rate of brain aging associates with future executive function in Asian children and older adults
Cheng, S. F.; Yue, W. L.; Ng, K. K.; Qian, X.; Liu, S.; Tan, T. W. K.; Nguyen, K.-N.; Leong, R. L. F.; Hilal, S.; Cheng, C.-Y.; Tan, A. P.; Law, E. C.; Gluckman, P. D.; Chen, C. L.-H.; Chong, Y. S.; Meaney, M. J.; Chee, M.; Yeo, B. T. T.; Zhou, J. H.
10.1101/2023.11.27.568184 — neuroscience — Posted on 2024-04-18
2073 Angiotensin-(1-5) is a Potent Endogenous Angiotensin AT2-Receptor Agonist
Souza-Silva, I. M.; Peluso, A. A.; Elsaafien, K.; Nazarova, A. L.; Assersen, K. B.; Rodrigues-Ribeiro, L.; Mohammed, M.; Rodrigues, A. F.; Nawrocki, A.; Johansen, L. A.; Jensen, P.; de Kloet, A. D.; Krause, E. G.; DelBorgo, M.; Maslov, I.; Widdop, R. E.; Santos, R. A. S.; Bader, M.; Larsen, M. R.; Verano-Braga, T.; Katritch, V.; Sumners, C.; Steckelings, U. M.
10.1101/2024.04.05.588367 — pharmacology and toxicology — Posted on 2024-04-18
2074 Axial de-scanning using remote focusing in the detection arm of light-sheet microscopy
Dibaji, H.; Shotorban, A. K. N.; Grattan, R. M.; Lucero, S.; Schodt, D. J.; Lidke, K. A.; Petruccelli, J.; Lidke, D. S.; Liu, S.; Chakraborty, T.
10.1101/2023.09.07.556729 — biophysics — Posted on 2024-04-18
2075 Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for Advanced MRS
Hui, S. C. N.; Murali-Manohar, S.; Zollner, H. J.; Hupfeld, K. E.; Davies-Jenkins, C. W.; Gudmundson, A. T.; Song, Y.; Yedavalli, V.; Wisnowski, J. L.; Gagoski, B.; Oeltzschner, G.; Edden, R. A. E.
10.1101/2024.02.15.580516 — bioengineering — Posted on 2024-04-18
2077 Profiling the LAM family of contact site tethers provides insights into their regulation and function
Fenech, E. J.; Kupervaser, M.; Boshnakovska, A.; Ravid, S.; Gomes Castro, I.; Asraf, Y.; Callegari, S.; Lenz, C.; Rehling, P.; Schuldiner, M.
10.1101/2024.04.18.590074 — cell biology — Posted on 2024-04-18
2078 TPR is required for cytoplasmic chromatin fragment formation during senescence
Bartlett, B. M.; Kumar, Y.; Boyle, S.; Chowdhury, T.; Quintanilla, A.; Boumendil, C.; Acosta, J. C.; Bickmore, W. A.
10.1101/2024.04.18.590085 — cell biology — Posted on 2024-04-18
2081 Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes
Nikonorova, I. A.; desRanleau, E.; Jacobs, K. C.; Saul, J.; Walsh, J. D.; Wang, J.; Barr, M. M.
10.1101/2024.04.17.588758 — cell biology — Posted on 2024-04-18
2083 WITHDRAWN: Genomic decoding of neuronal depolarization by stimulus-specific NPAS4 heterodimers
Brigidi, G. S.; Hayes, M. G. B.; Hartzell, A. L.; Texari, L.; Lin, P.-A.; Bartlett, A.; Ecker, J. R.; Benner, C.; Heinz, S.; Bloodgood, B. L.
10.1101/565721 — neuroscience — Posted on 2024-04-18
2089 A micro-RNA is the effector gene of a classic evolutionary hotspot locus
Tian, S.; Asano, Y.; Banerjee, T. D.; Wee, J. L. Q.; Lamb, A.; Wang, Y.; Murugesan, S. N.; Ui-Tei, K.; Wittkopp, P. J.; Monteiro, A.
10.1101/2024.02.09.579741 — evolutionary biology — Posted on 2024-04-18
2095 Connectome-driven neural inventory of a complete visual system
Nern, A.; Loesche, F.; Takemura, S.-y.; Burnett, L. E.; Dreher, M.; Gruntman, E.; Hoeller, J.; Huang, G. B.; Januszewski, M.; Klapoetke, N. C.; Koskela, S.; Longden, K. D.; Lu, Z.; Preibisch, S.; Qiu, W.; Rogers, E. M.; Seenivasan, P.; Zhao, A.; Bogovic, J.; Canino, B. S.; Clements, J.; Cook, M.; Finley-May, S.; Flynn, M. A.; Hameed, I.; Hayworth, K. J.; Hopkins, G. P.; Hubbard, P. M.; Katz, W. T.; Kovalyak, J.; Lauchie, S. A.; Leonard, M.; Lohff, A.; Maldonado, C. A.; Mooney, C.; Okeoma, N.; Olbris, D. J.; Ordish, C.; Paterson, T.; Phillips, E. M.; Pietzsch, T.; Rivas Salinas, J.; Rivlin, P.
10.1101/2024.04.16.589741 — neuroscience — Posted on 2024-04-18
2096 METABOLIC MODELLING AS A POWERFUL TOOL TO IDENTIFY CRITICAL COMPONENTS OF THE PNEUMOCYSTIS GROWTH MEDIUM
Nev, O. A.; Zamaraeva, E.; De Oliveira, R.; Duvenage, L.; Abou-Jaoude, W.; Ouattara, D. A.; Hoving, J. C.; Gudelj, I.; Brown, A. J. P.
10.1101/2023.06.07.544035 — systems biology — Posted on 2024-04-18
2098 Complementing Muscle Regeneration: Fibro-Adipogenic Progenitor and Macrophage-Mediated Repair of Elderly Human Skeletal Muscle
Brorson, J.; Lin, L.; Wang, J.; Billeskov, T.; Just, J.; Hasko, J.; Ravn, C.; Hansen, R. L.; Bue, M.; Luo, Y.; Jessen, N.; Farup, J.
10.1101/2024.04.18.590053 — physiology — Posted on 2024-04-18
2102 The Genetic Origin of the Indo-Europeans
Lazaridis, I.; Patterson, N.; Anthony, D.; Vyazov, L.; Fournier, R.; Ringbauer, H.; Olalde, I.; Khokhlov, A. A.; Kitov, E. P.; Shishlina, N. I.; Ailincai, S. C.; Agapov, D. S.; Agapov, S. A.; Batieva, E.; Bauyrzhan, B.; Bereczki, Z.; Buzhilova, A.; Changmai, P.; Chizhevsky, A. A.; Ciobanu, I.; Constantinescu, M.; Csanyi, M.; Dani, J.; Dashkovskiy, P. K.; Evinger, S.; Faifert, A.; Flegontov, P. N.; Frinculeasa, A.; Frinculeasa, M. N.; Hajdu, T.; Higham, T.; Jarosz, P.; Jelinek, P.; Khartanovich, V. I.; Kirginekov, E. N.; Kiss, V.; Kitova, A.; Kiyashko, A. V.; Koledin, J.; Korolev, A.; Kosintsev
10.1101/2024.04.17.589597 — genetics — Posted on 2024-04-18
2106 Elevated body mass index in youth is associated with dysregulated surrogate markers of neural inhibition & excitation, and internetwork functional dysconnectivity
Reichelt, A. C.; Daskalakis, E.; Cohen, J.; Solar, K. G.; Saberi, M.; Ventresca, M.; Ali, M.; Zamyadi, R.; Scratch, S.; Hamilton, J.; Dunkley, B. T.
10.1101/2024.04.18.590064 — neuroscience — Posted on 2024-04-18
2111 Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism
Lin, S.; Gade, A. R.; Wang, H.-G.; Niemeyer, J. E.; Galante, A.; DiStefano, I.; Towers, P.; Nunez, J.; Schwartz, T. H.; Rajadhyaksha, A.; Pitt, G. S.
10.1101/2024.04.18.590019 — neuroscience — Posted on 2024-04-18
2112 Beyond oscillations - A novel feature space for characterizing brain states
Balestrieri, E.; Chalas, N.; Stier, C.; Fehring, J.; Gil Avila, C.; Dannlowski, U.; Ploner, M.; Gross, J.
10.1101/2024.04.17.589917 — neuroscience — Posted on 2024-04-18
2113 Roles of the 5-HT1A receptor in zebrafish responses to potential threat and in sociality
de Sousa, L. V. X. B.; de Oliveira, L. N.; Costa, B. P. D.; Lima-Maximino, M.; Correa, H. V. V.; Maximino, C.
10.1101/2024.04.17.588464 — neuroscience — Posted on 2024-04-18
2117 A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling
Vasou, A.; Nightingale, K.; Cetkovska, V.; Scheler, J.; Bamford, C. G.; Andrejeva, J.; Schwarz-Linek, U.; Randall, R. E.; McLauchlan, J.; Weekes, M. P.; Bogunovic, D.; Hughes, D. J.
10.1101/2021.06.01.446527 — immunology — Posted on 2024-04-18
2119 Feeding-state dependent modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila
de Tredern, E.; Manceau, D.; Blanc, A.; Sakagiannis, P.; Barre, C.; Sus, V.; Viscido, F.; Hasan, M. A.; Autran, S.; Nawrot, M.; Masson, J.-B.; Jovanic, T.
10.1101/2023.12.26.573306 — neuroscience — Posted on 2024-04-18
2122 T7 DNA polymerase treatment improves quantitative sequencing of both double-stranded and single-stranded DNA viruses
Billaud, M.; Theodorou, I.; Lamy-Besnier, Q.; Shah, S. A.; Lecointe, F.; De Sordi, L.; De Paepe, M.; Petit, M.-A.
10.1101/2022.12.12.520144 — genomics — Posted on 2024-04-18
2125 A Foundational Large Language Model for Edible Plant Genomes
Mendoza-Revilla, J.; Trop, E.; Gonzalez, L.; Roller, M.; Dalla-Torre, H.; de Almeida, B. P.; Richard, G.; Caton, J.; Lopez Carranza, N.; Skwark, M.; Laterre, A.; Beguir, K.; Pierrot, T.; Lopez, M.
10.1101/2023.10.24.563624 — genomics — Posted on 2024-04-18
2126 Late stages of the Zika virus life cycle are impaired by a selective TRPML2 agonist
Schwickert, K. K.; Glitscher, M.; Bender, D.; Murra, R.; Schwickert, K.; Pfalzgraf, S.; Schirmeister, T.; Hellmich, U. A.; Hildt, E.
10.1101/2024.02.01.578205 — cell biology — Posted on 2024-04-18
2127 Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation
Miao, Y.; Du, Y.; Wang, B.; Liang, J.; Liang, Y.; Dang, S.; Liu, J.; Li, D.; He, K.; Ding, M.
10.1101/2024.01.10.575034 — cell biology — Posted on 2024-04-18
2131 A lipidome Aging Clock shows Age Acceleration in individuals with Autism
Latumalea, D.; Unfried, M.; Barardo, D. G.; Gruber, J.; Kennedy, B. K.
10.1101/2024.02.01.578331 — neuroscience — Posted on 2024-04-18
2133 Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Swissa, E.; Monsonego, U.; Yang, L. T.; Schori, L.; Kamintsky, L.; Mirloo, S.; Burger, I.; Uzzan, S.; Patel, R.; Sudmant, P. H.; Prager, O.; Kaufer, D.; Friedman, A.
10.1101/2023.04.23.537964 — neuroscience — Posted on 2024-04-18
2136 An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Thiopurine Resistance in Acute Lymphoblastic Leukemia
Diz, M. T.; Reglero, C.; Falkenstein, C. D.; Castro, A.; Hayer, K. E.; Radens, C.; Quesnel-Vallieres, M.; Ang, Z.; Sehgal, P.; Li, M. M.; Barash, Y.; Tasian, S. K.; Ferrando, A.; Thomas-Tikhonenko, A.
10.1101/2023.09.14.557413 — cancer biology — Posted on 2024-04-18
2143 Harnessing full-text publications for deep insights into C. elegans and Drosophila connectomes
ARULPRAKASAM, K. R.; TOH, J. W. S.; FOO, H.; KUMAR, M. R.; KUTEVSKA, A.-N.; DAVEY, E. E.; MUTWIL, M.; THIBAULT, G.
10.1101/2024.04.13.588993 — bioinformatics — Posted on 2024-04-18
2149 Spirolactone, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis
Yang, Z.; Qiao, Y.; Strobech, E.; Morth, J. P.; Walther, G.; Jorgensen, T. S.; Peschel, G.; Rosenbaum, M. A.; Previtali, V.; Clausen, M. H.; Lukassen, M. V.; Gotfredsen, C. H.; Kurzai, O.; weber, t.; Ding, L.
10.1101/2024.04.17.589928 — biochemistry — Posted on 2024-04-18
2150 Levy statistics define anxiety and depression in mice subjected to chronic stress
Li, Q.; Nie, Y.; Li, X.; Luo, Y.; Zhao, B.; Zhang, N.; Kuang, W.; Tian, C.; Chen, D.; Zhang, Y.; Wu, Z.; Zhong, Z.
10.1101/2023.06.18.545232 — animal behavior and cognition — Posted on 2024-04-18
2154 The Statistical Building Blocks of Animal Movement Simulations
Getz, W. M.; Salter, R.; Sethi, V.; Cain, S.; Spiegel, O.; Toledo, S.
10.1101/2023.12.27.573450 — ecology — Posted on 2024-04-18
2155 GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade
Walker, M. F.; Zhang, J.; Steiner, W.; Ku, P.-I.; Zhu, J.-F.; Michaelson, Z.; Yen, Y.-C.; Lee, A.; Long, A. B.; Casey, M. J.; Poddar, A.; Nelson, I. B.; Arveseth, C. D.; Nagel, F.; Clough, R.; LaPotin, S.; Kwan, K. M.; Schulz, S.; Stewart, R. A.; Tesmer, J. J. G.; Caspary, T.; Subramanian, R.; Ge, X.; Myers, B. R.
10.1101/2023.05.10.540226 — cell biology — Posted on 2024-04-18
2156 Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice
En, A.; Bogireddi, H.; Thomas, B.; Stutzman, A.; Ikegami, S.; LaForest, B.; Almakki, O.; Pytel, P.; Moskowitz, I. P.; Ikegami, K.
10.1101/2023.08.28.555134 — molecular biology — Posted on 2024-04-18
2160 Natural language processing models reveal neural dynamics of human conversation
Cai, J.; Hadjinicolaou, A. E.; Paulk, A. C.; Soper, D. J.; Xia, T.; Williams, Z. M.; Cash, S. S.
10.1101/2023.03.10.531095 — neuroscience — Posted on 2024-04-18
2161 Dark side of the honeymoon: reconstructing the Asian x European rose breeding history through the lens of genomics
Leroy, T.; Albert, E.; Thouroude, T.; Baudino, S.; Caissard, J.-C.; Chastellier, A.; Chameau, J.; Jeauffre, J.; Loubert, T.; Paramita, S. N.; Pernet, A.; Soufflet-Freslon, V.; Oghina-Pavie, C.; Foucher, F.; Oyant, L. H.-S.; Clotault, J.
10.1101/2023.06.22.546162 — genomics — Posted on 2024-04-18
2162 Enhancer-driven cell type comparison reveals similarities between the mammalian and bird pallium
Hecker, N.; Kempynck, N.; Mauduit, D.; Abaffyova, D.; Vandepoel, R.; Dieltiens, S.; Sarropoulos, I.; Bravo Gonzalez-Blas, C.; Leysen, E.; Moors, R.; Hulselmans, G.; Lim, L.; De Wit, J.; Christiaens, V.; Poovathingal, S.; Aerts, S.
10.1101/2024.04.17.589795 — genomics — Posted on 2024-04-18
2163 A genomic history of the North Pontic Region from the Neolithic to the Bronze Age
Nikitin, A. G.; Lazaridis, I.; Patterson, N.; Ivanova, S.; Videiko, M.; Dergachev, V.; Kotova, N.; Lillie, M.; Potekhina, I.; Krenz-Niedbała, M.; Łukasik, S.; Makhortykh, S.; Renson, V.; Shephard, H.; Sirbu, G.; Svyryd, S.; Tkachuk, T.; Włodarczak, P.; Callan, K.; Curtis, E.; Harney, E.; Iliev, L.; Kearns, A.; Lawson, A. M.; Michel, M.; Mah, M.; Micco, A.; Oppenheimer, J.; Qiu, L.; Workman, J. N.; Zalzala, F.; Mallick, S.; Rohland, N.; Reich, D.
10.1101/2024.04.17.589600 — genetics — Posted on 2024-04-18
2165 Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis
Mason, D. E.; Camacho, P.; Goeckel, M.; Tobin, B. R.; Vega, S. L.; Wu, P.-H.; Johnson, D.; Heo, S.-J.; Wirtz, D.; Burdick, J. A.; Wood, L.; Chow, B. Y.; Stratman, A. N.; Boerckel, J. D.
10.1101/2022.06.15.496293 — cell biology — Posted on 2024-04-18
2170 Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes
Nemkov, T.; Stephenson, D.; Earley, E. J.; Keele, G. R.; Hay, A.; Key, A. M.; Haiman, Z.; Erickson, C.; Dzieciatkowska, M.; Reisz, J. A.; Moore, A.; Stone, M.; Deng, X.; Kleinman, S.; Spitalnik, S. L.; Hod, E. A.; Hudson, K. E.; Hansen, K. C.; Palsson, B. O.; Churchill, G. A.; Roubinian, N.; Norris, P. J.; Busch, M. P.; Zimring, J. C.; Page, G. P.; D'Alessandro, A.
10.1101/2023.09.11.557250 — biochemistry — Posted on 2024-04-17
2171 Biocalcification in porcelaneous foraminifera
Dubicka, Z.; Tyszka, J.; Palczynska, A.; Hohne, M.; Bijma, J.; Janse, M.; Klerks, N.; Bickmeyer, U.
10.1101/2023.10.02.560476 — evolutionary biology — Posted on 2024-04-17
2172 Features that matter: evolutionary signatures that predict viral transmission routes
Wardeh, M.; Pilgrim, J.; Hui, M.; Kotsiri, A.; Baylis, M.; Blagrove, M. S.
10.1101/2023.11.22.568327 — ecology — Posted on 2024-04-17
2173 Acclimation Capacity to Global Warming of Amphibians and Freshwater Fishes: Drivers, Patterns, and Data Limitations
Ruthsatz, K.; Dahlke, F.; Alter, K.; Wohlrab, S.; Eterovick, P. C.; Lyra, M. L.; Gippner, S.; Cooke, S. J.; Peck, M. A.
10.1101/2023.12.22.573141 — ecology — Posted on 2024-04-17
2177 OCA-B promotes autoimmune demyelination through control of stem-like CD4+ T cells
Hughes, E. P.; Syage, A. R.; Mehrabad, E. M.; Lane, T. E.; Spike, B. T.; Tantin, D.
10.1101/2023.11.29.569210 — immunology — Posted on 2024-04-17
2178 Spatiotemporal brain complexity quantifies consciousness outside of perturbation paradigms
Breyton, M.; Fousek, J.; Rabuffo, G.; Sorrentino, P.; Kusch, L.; Massimini, M.; Petkoski, S.; Jirsa, V.
10.1101/2023.04.18.537321 — neuroscience — Posted on 2024-04-17
2181 Assessing AF2's ability to predict structural ensembles of proteins
Riccabona, J. R.; Spoendlin, F. C.; Fischer, A.-L. M.; Loeffler, J. R.; Quoika, P. K.; Jenkins, T. P.; Ferguson, J. A.; Smorodina, E.; Laustsen, A. H.; Greiff, V.; Forli, S.; Ward, A.; Deane, C.; Fernandez-Quintero, M. L.
10.1101/2024.04.16.589792 — biophysics — Posted on 2024-04-17
2183 Atp1a2 and Kcnj9 are candidate genes underlying oxycodone behavioral sensitivity and withdrawal in C57BL/6 substrains
Goldberg, L. R.; Baskin, B. M.; Adla, Y.; Beierle, J. A.; Kelliher, J. C.; Yao, E. J.; Kirkpatrick, S. L.; Reed, E. R.; Jenkins, D. F.; Luong, A. M.; Luttik, K. P.; Scotellaro, J. A.; Drescher, T. A.; Crotts, S. B.; Yazdani, N.; Ferris, M. T. R.; Johnson, W. E.; Mulligan, M. K.; Bryant, C. D.
10.1101/2024.04.16.589731 — genetics — Posted on 2024-04-17
2186 Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus
Ulrich, R. J.; Podkowik, M.; Tierce, R.; Irnov, I.; Putzel, G.; Samhadaneh, N.; Lacey, K. A.; Boff, D.; Morales, S. M.; Makita, S.; Karagounis, T. K.; Zwack, E. E.; Zhou, C.; Kim, R.; Drlica, K.; Pironti, A.; van Bakel, H.; Torres, V. J.; Shopsin, B.
10.1101/2024.04.17.589803 — microbiology — Posted on 2024-04-17
2187 Microbial resistance and resilience to drought under organic and conventional farming
Kost, E.; Kundel, D.; Feola Conz, R.; Maeder, P.; Krause, H.-M.; Six, J.; Mayer, J.; Hartmann, M.
10.1101/2024.04.17.589021 — microbiology — Posted on 2024-04-17
2190 Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells
Ma, L.; Ramasubramanian, R.; Mehta, N.; Cossette, B.; Morgan, D.; Sukaj, I.; Bergaggio, E.; Kadauke, S.; Myers, R.; Paruzzo, L.; Ghilardi, G.; Grzywa, T.; Cozzone, A.; Schuster, S.; Frey, N.; Zhang, L.; Yousefpour, P.; Abraham, W.; Suh, H.; Ruella, M.; Grupp, S.; Chiarle, R.; Wittrup, K. D.; Irvine, D. J.
10.1101/2024.04.16.589780 — bioengineering — Posted on 2024-04-17
2191 Spirolactone, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis
Yang, Z.; Qiao, Y.; Strobech, E.; Morth, J. P.; Walther, G.; Jorgensen, T. S.; Peschel, G.; Rosenbaum, M. A.; Previtali, V.; Clausen, M. H.; Lukassen, M. V.; Gotfredsen, C. H.; Kurzai, O.; Ding, L.
10.1101/2024.04.17.589928 — biochemistry — Posted on 2024-04-17
2192 Genomic diversity and evolution in the Hawaiian Islands endemic Kokia (Malvaceae)
Kayal, E.; Arick, M. A.; Hsu, C.-y.; Thrash, A.; Yorkston, M.; Morden, C. W.; Wendel, J. F.; Peterson, D. G.; Grover, C. E.
10.1101/2024.04.17.589907 — genomics — Posted on 2024-04-17
2196 Mitochondria-targeted hydrogen sulfide donor reduces fatty liver and obesity in mice fed a high fat diet by inhibiting de novo lipogenesis and inflammation via mTOR/SREBP-1 and NF-κB signaling pathways
Stachowicz, A.; Czepiel, K.; Wisniewska, A.; Stachyra, K.; Ulatowska-Bialas, M.; Kusnierz-Cabala, B.; Surmiak, M.; Majka, G.; Kus, K.; Wood, M. E.; Torregrossa, R.; Whiteman, M.; Olszanecki, R.
10.1101/2024.04.17.589169 — molecular biology — Posted on 2024-04-17
2198 IncC plasmid genome rearrangements influence the vertical and horizontal transmission tradeoff in Escherichia coli
Allain, M.; Morel-Journel, T.; Condamine, B.; Gibeaux, B.; Gachet, B.; GSCHWIND, R.; Denamur, E.; Landraud, L.
10.1101/2024.04.17.589899 — microbiology — Posted on 2024-04-17
2199 PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
Karim, M.; Mishra, M.; Lo, C.-W.; Saul, S.; Cagirici, H. B.; Nhu Tran, D. H.; Agrawal, A.; Ghita, L.; Ojha, A.; P. East, M.; Anbro Gammeltoft, K.; Kumar Sahoo, M.; L. Johnson, G.; Das, S.; Jochmans, D.; A. Cohen, C.; Gottwein, J.; Dye, J.; Neff, N.; A. Pinsky, B.; Laitinen, T.; Pantsar, T.; Poso, A.; Zanini, F.; De Jonghe, S.; R M Asquith, C.; Einav, S.
10.1101/2024.04.15.589676 — microbiology — Posted on 2024-04-17
2200 Coenzyme A biosynthesis in Bacillus subtilis: Discovery of a novel precursor metabolite for salvage and its uptake system
Warneke, R.; Herzberg, C.; Klein, M.; Elfmann, C.; Dittmann, J. L.; Feussner, K.; Feussner, I.; Stulke, J.
10.1101/2024.04.17.589903 — microbiology — Posted on 2024-04-17
2201 BatR: A novel regulator of antibiotic tolerance in Pseudomonas aeruginosa biofilms
Piazza, A. M.; Dasanayaka, H.; Martins, C.; Saalbach, G.; Trampari, E.; Webber, M. A.; Harrison, F.; Malone, J.
10.1101/2024.04.17.589660 — microbiology — Posted on 2024-04-17
2202 Lifestyle-specific responses of Trichoderma spp. in mycoparasitic confrontations and implications for biocontrol of Populus x canescens
Stange, P.; Kersting, J.; Sivaprakasam Padmanaban, P. B.; Schnitzler, J.-P.; Rosenkranz, M.; Karl, T.; Benz, J. P.
10.1101/2024.04.17.589723 — microbiology — Posted on 2024-04-17
2203 NSm is a critical determinant for bunyavirus transmission between vertebrate and arthropod hosts
Terhzaz, S.; Kerrigan, D.; Almire, F.; Szemiel, A. M.; Palmarini, M.; Kohl, A.; Shi, X.; Pondeville, E.
10.1101/2024.04.17.589932 — microbiology — Posted on 2024-04-17
2205 SARS-CoV2 infection triggers reactive astrocyte states and inflammatory conditions in long-term Human Cortical Organoids
Colinet, M.; Chiver, I.; Bonafina, A.; Masset, G.; Almansa, D.; Di Valentin, E.; Twizere, J.-C.; Nguyen, L.; Espuny-Camacho, I.
10.1101/2024.04.16.589036 — neuroscience — Posted on 2024-04-17
2206 FicD regulates adaptation to the unfolded protein response in the murine liver.
Casey, A. K.; Stewart, N. M.; Zaidi, N.; Gray, H. A.; Cox, A.; Fields, H. A.; Orth, K.
10.1101/2024.04.15.589620 — physiology — Posted on 2024-04-17
2210 Nicheformer: a foundation model for single-cell and spatial omics
Schaar, A. C.; Tejada-Lapuerta, A.; Palla, G.; Gutgesell, R.; Halle, L.; Minaeva, M.; Vornholz, L.; Dony, L.; Drummer, F.; Bahrami, M.; Theis, F. J.
10.1101/2024.04.15.589472 — bioinformatics — Posted on 2024-04-17
2213 Assessment of the level of pollution based on soil and Tilia europaea leaves
Simon, E.; Haziq, I. B.; Sipos, B.; Abriha-Molnar, V. E.; Abriha, D.; Tozser, D.; Boluda, H. R.; Roca, P. L.
10.1101/2024.04.17.589890 — ecology — Posted on 2024-04-17
2214 Anatomical and functional studies of isolated vestibular neuroepithelia from Meniere's Disease patients
Drury, H. R.; Tadros, M. A.; Callister, R. J.; Brichta, A. M.; Eisenberg, R. L.; Lim, R.
10.1101/2024.04.15.589685 — neuroscience — Posted on 2024-04-17
2216 Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation
Yuan, Y.; Li, H.; Sreeram, K.; Malankhavnova, T.; Boddu, R.; Strader, S.; Chang, A.; Bryant, N.; Yacoubian, T.; Standaert, D. G.; Erb, M.; Moore, D. J.; Sanders, L. H.; Lutz, M. W.; Velmeshev, D.; West, A. B.
10.1101/2024.04.15.589570 — neuroscience — Posted on 2024-04-17
2218 Bi-directional allosteric pathway in NMDA receptor activation and modulation
Bender, P.; Chakraborty, S.; Durham, R.; Berka, V.; CarrilloFlores, E.; Jayaraman, V.
10.1101/2024.04.16.589813 — biophysics — Posted on 2024-04-17
2219 DeProt: A protein language model with quantizied structure and disentangled attention
Li, M.; Tan, Y.; Zhong, B.; Zhou, Z.; Yu, H.; Ma, X.; Ouyang, W.; Hong, L.; Zhou, B.; Tan, P.
10.1101/2024.04.15.589672 — bioinformatics — Posted on 2024-04-17
2220 Accurate estimation of SNP genotypes and genetic relatedness from DNA methylation data
Jiang, Y.; Qu, M.; Jiang, M.; Jiang, X.; Fernandez, S.; Porter, T.; Laws, S. M.; Masters, C. L.; Guo, H.; Cheng, S.; Wang, C.
10.1101/2024.04.15.589670 — bioinformatics — Posted on 2024-04-17
2221 AutoGaitA - Automated Gait Analysis in Python
Hosseini, M.; Klein, I.; Kuzu, T. D.; Semmler, C.; Wunderle, V.; Mardare, V.; Galvao, A.; Haustein, M.; Bueschges, A.; Grefkes, C.; Korotkova, T.; Fink, G. R.; Weiss, P. H.; Gatto, G.; Daun, S.
10.1101/2024.04.14.589409 — animal behavior and cognition — Posted on 2024-04-17
2225 Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition
Misiachna, A.; Konecny, J.; Kolcheva, M.; Ladislav, M.; Prchal, L.; Netolicky, J.; Kortus, S.; Barackova, P.; Langore, E.; Novak, M.; Hemelikova, K.; Hermanova, Z.; Hrochova, M.; Pelikanova, A.; Odvarkova, J.; Pejchal, J.; Kassa, J.; Karasova, J. Z.; Korabecny, J.; Soukup, O.; Horak, M.
10.1101/2024.04.15.589518 — neuroscience — Posted on 2024-04-17
2227 The cochlear hook region detects harmonics beyond the canonical hearing range
Horii, K.; Ogawa, B.; Nagase, N.; Morimoto, I.; Abe, C.; Ogawa, T.; Choi, S.; Nin, F.
10.1101/2024.04.14.589450 — physiology — Posted on 2024-04-17
2228 Caveolar Compartmentalization is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure
Lang, D.; Ni, H.; Medvedev, R.; Liu, F. V.; Alvarez-Baron, C.; Tyan, L.; Turner, D.; Warden, A.; Morotti, S.; Schrauth, T.; Rickert, C.; Proenza, C.; Chanda, B.; Kamp, T. J.; Robertson, G.; Grandi, E.; Glukhov, A. V.
10.1101/2024.04.14.589457 — physiology — Posted on 2024-04-17
2229 Longitudinal Exposomics in a Multiomic Wellness Cohort Reveals Distinctive and Dynamic Environmental Chemical Mixtures in Blood
Sdougkou, K.; Papazian, S.; Bonnefille, B.; Xie, H.; Edfors, F.; Fagerberg, L.; Uhlen, M.; Bergström, G.; Martin, L. J.; Martin, J. W.
10.1101/2024.04.14.589329 — pharmacology and toxicology — Posted on 2024-04-17
2232 Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma
Russell, R.; Akuma, M.; Kim, M.; Zhu, C.; Wiljer, E.; Gaudreau-Lapierre, A.; Patterson, L.; Trinkle-Mulcahy, L.; Stanford, W. L.; Riazalhosseini, Y.
10.1101/2024.04.14.589424 — cancer biology — Posted on 2024-04-17
2233 Induced electric fields inhibit breast cancer growth and metastasis by modulating the immune tumor microenvironment
Charan, M.; Jones, T. H.; Ahirwar, D. K.; Acharya, N.; Subramaniam, V. V.; Ganju, R. K.; Song, J. W.
10.1101/2024.04.14.589256 — cancer biology — Posted on 2024-04-17
2237 The transcripts of a gastrula-premarked enhancer prime posterior tissue development through cross-talk with morphogen effector
Chen, Y.; Tan, F.; Yang, X.; Fang, Q.; Zhang, L.; Liao, J.; Shen, P.; Qian, Y.; Wen, M.; Song, R.; Fu, Y.; Xu, H. J.; Wang, R.; Li, C.; Shao, Z.; Li, J.; Jing, N.
10.1101/2024.04.14.589453 — developmental biology — Posted on 2024-04-17
2238 Simple recombinant monoclonal antibody production from E. coli.
Baker, K.; Eastwood, T. A.; Garcia, E.; Lennon, C.; Mulvihill, D. P.
10.1101/2024.04.17.589891 — molecular biology — Posted on 2024-04-17
2240 An optogenetic assay for the dauer decision in Caenorhabditis elegans
Parker, A.; Mullins, J.; Corver, A.; Miller, A.; Mosley, I.; Gordus, A. G.
10.1101/2024.04.15.589657 — neuroscience — Posted on 2024-04-17
2243 A new leaf sensing organ in a predatory insect group, the praying mantises (Mantodea)
Brannoch, S. K.; Katzke, J.; Taylor, D. S.; Economo, E. P.; Ogawa, Y.; Narendra, A.; Svenson, G. J.; Martin, J. P.
10.1101/2024.04.14.589444 — zoology — Posted on 2024-04-17
2248 Lateral Entorhinal Cortex Dysfunction in Alzheimer's Disease Mice
Raghuraman, R.; Aoun, A.; Herman, M.; Shetler, C. O.; Nahmani, E.; Hussaini, S. A.
10.1101/2024.04.15.589589 — neuroscience — Posted on 2024-04-17
2251 Tracking small animals in complex landscapes: a comparison of localisation workflows for automated radio telemetry systems
Rueda-Uribe, C.; Sargent, A. J.; Echeverry-Galvis, M. A.; Camargo-Martinez, P. A.; Capellini, I.; Lancaster, L. T.; Rico-Guevara, A.; Travis, J. M. J.
10.1101/2024.04.14.589351 — ecology — Posted on 2024-04-17
2254 A low-resource reliable pipeline to democratize multi-modal connectome estimation and analysis
Chung, J.; Lawrence, R.; Loftus, A.; Kiar, G.; Bridgeford, E.; Consortium for Reliability and Reproducibility, ; Chandrashekhar, V.; Mhembere, D.; Ryman, S.; Zuo, X.-N.; Margulies, D.; Craddock, R. C.; Priebe, C. E.; Jung, R.; Calhoun, V. D.; Caffo, B.; Burns, R.; Milham, M. P.; Vogelstein, J.
10.1101/2021.11.01.466686 — bioinformatics — Posted on 2024-04-17
2255 Major Metabolites From Hypericum perforatum L., Hyperforin And Hypericin, Are Both Active Against Human Coronaviruses
Raczkiewicz, I.; Riviere, C.; Bouquet, P.; Desmarets, L.; Tarricone, A.; Camuzet, C.; Francois, N.; Lefevre, G.; Samaillie, J.; Silva Angulo, F.; Robil, C.; Trottein, F.; Sahpaz, S.; Dubuisson, J. D.; Belouzard, S.; Goffard, A.; Seron, K.
10.1101/2024.04.09.588755 — microbiology — Posted on 2024-04-17
2256 Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease
Binns, T. S.; Köhler, R. M.; Vanhoecke, J.; Chikermane, M.; Gerster, M.; Merk, T.; Pellegrini, F.; Busch, J. L.; Habets, J. G. V.; Cavallo, A.; Li, N.; Horn, A.; Krause, P.; Faust, K.; Schneider, G.-H.; Haufe, S.; Kühn, A. A.; Neumann, W.-J.
10.1101/2024.04.14.586969 — neuroscience — Posted on 2024-04-17
2257 Vestibular-derived internal models in active self-motion estimation
van Helvert, M. J. L.; Selen, L. P. J.; van Beers, R.; Medendorp, W. P.
10.1101/2024.04.14.589435 — neuroscience — Posted on 2024-04-17
2259 Muscarinic receptors mediate motivation via preparatory neural activity in humans
Grogan, J. P.; Raemaekers, M.; van Swieten, M. M. H.; Green, A. L.; Gillies, M. J.; Manohar, S. G.
10.1101/2021.07.28.454154 — neuroscience — Posted on 2024-04-17
2260 Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity
Wu, Y.; Song, Y.; Soto, J.; Hoffman, T.; Zhang, A.; Han, X.; Fang, Z.; Eoh, J.; Gu, L.; Gu, Z.; Li, S.
10.1101/2024.04.14.589442 — cell biology — Posted on 2024-04-17
2261 Lateral Entorhinal Cortex Dysfunction in Alzheimers Disease Mice
Raghuraman, R.; Aoun, A.; Herman, M.; Shetler, C. O.; Nahmani, E.; Hussaini, S. A.
10.1101/2024.04.15.589589 — neuroscience — Posted on 2024-04-17
2262 Chromosome-level assembly of Cucumis sativus cv. 'Tokiwa' as a reference genome of Japanese cucumber
Seiko, T.; Muto, C.; Shimomura, K.; Yano, R.; Kawazu, Y.; Sugiyama, M.; Kato, K.; Tomooka, N.; Naito, K.
10.1101/2024.04.15.589484 — genomics — Posted on 2024-04-17
2263 Sex-specific recombination landscape in a species with holocentric chromosomes
Chmielewski, S.; Konczal, M.; Parrett, J. M.; Rombauts, S.; Dudek, K.; Radwan, J.; Babik, W.
10.1101/2024.04.15.589577 — genomics — Posted on 2024-04-17
2264 Changes in growth, lanthanide binding, and gene expression in Pseudomonas alloputida KT2440 in response to light and heavy lanthanides
Gorniak, L.; Bucka, S. L.; Nasr, B.; Cao, J.; Hellmann, S.; Schäfer, T.; Westermann, M.; Bechwar, J.; Wegner, C.-E.
10.1101/2024.04.15.589537 — microbiology — Posted on 2024-04-17
2267 Chemical codes promote selective compartmentalization of proteins
Kilgore, H.; Chinn, I.; Mikhael, P.; Mitnikov, I.; Van Dongen, C.; Zylberberg, G.; Afeyan, L.; Banani, S.; Wilson-Hawken, S.; Lee, T.; Barzialy, R.; Young, R.
10.1101/2024.04.15.589616 — biochemistry — Posted on 2024-04-17
2268 The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
Zhang, I.; Boezio, G. L.; Cornwall-Scoones, J.; Frith, T.; Jiang, M.; Howell, M.; Lovell-Badge, R.; Sagner, A.; Briscoe, J.; Delas, M. J.
10.1101/2024.04.17.589864 — developmental biology — Posted on 2024-04-17
2269 A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia
Chen, M.; Zhao, Y.; Xu, X.; Zhang, X.; Zhang, J.; Wu, S.; Liu, Z.; Yuan, Y.; Guo, X.; Qi, S.; Yi, G.; Wang, S.; Li, H.; Wu, A.; Liu, G.; Yu, K.; Deng, S.; Han, H.; Lv, F.; Li, Y.; Lian, Z.
10.1101/2023.03.09.531872 — cell biology — Posted on 2024-04-17
2271 Diversity in the internal functional feeding elements of sympatric morphs of Arctic charr (Salvelinus alpinus)
Jonsdottir, G. O.; von Elm, L.-M.; Ingimarsson, F.; Tersigni, S.; Snorrason, S. S.; Palsson, A.; Steele, S. E.
10.1101/2023.02.17.528955 — evolutionary biology — Posted on 2024-04-17
2276 Multidimensional analysis of cortical interneuron synaptic features reveals underlying synaptic heterogeneity
Dummer, P.; Lee, D.; Hossain, S.; Wang, R.; Evard, A.; Newman, G.; Ho, C.; Schneider-Mizell, C. M.; Menon, V.; Au, E.
10.1101/2024.03.22.586340 — neuroscience — Posted on 2024-04-17
2277 EEG biomarkers of α5-GABA positive allosteric modulators in rodents
Mazza, F.; Guet-McCreight, A.; Prevot, T. D.; Valiante, T. A.; Sibille, E.; Hay, E.
10.1101/2024.03.26.586837 — neuroscience — Posted on 2024-04-17
2278 Systematic transcriptomic analysis and temporal modelling of the senescent human fibroblast
Scanlan, R.-L.; Pease, L.; O'Keefe, H.; Martinez-Guimera, A.; Shanley, D.; Wordsworth, J.
10.1101/2022.08.16.504144 — systems biology — Posted on 2024-04-17
2281 Structure and function of an intermediate GPCR-G protein complex
Bi, M.; Wang, X.; Wang, J.; Xu, J.; Sun, W.; Adediwura, V. A.; Miao, Y.; Cheng, Y.; Ye, L.
10.1101/2024.04.02.587841 — biophysics — Posted on 2024-04-17
2282 Wide Transition-State Ensemble as Key Component for Enzyme Catalysis
Jara, G. E.; Pontiggia, F.; Otten, R.; Agafonov, R. V.; Marti, M. A.; Kern, D.
10.1101/2023.10.03.560706 — biophysics — Posted on 2024-04-17
2283 Mechanism of Dimer Selectivity and Binding Cooperativity of BRAF inhibitors
Clayton, J.; Romany, A.; Matenoglou, E.; Gavathiotis, E.; Poulikakos, P. I.; Shen, J.
10.1101/2023.12.12.571293 — biophysics — Posted on 2024-04-17
2285 OneNet -- One network to rule them all: consensus network inference from microbiome data
Champion, C.; Momal, R.; Le Chatelier, E.; SOLA, M.; Mariadassou, M.; Berland, M.
10.1101/2023.05.05.539529 — bioinformatics — Posted on 2024-04-17
2287 Automated cell type annotation and exploration of single-cell signalling dynamics using mass cytometry
Kleftogiannis, D.; Gavasso, S.; Tislevoll, B. S.; van der Meer, N.; Motzfeldt, I. K. F.; Hellesoy, M.; Gullaksen, S.-E.; Griessinger, E.; Fagerholt, O.; Lenartova, A.; Floisand, Y.; Schuringa, J. J.; Gjertsen, B. T.; Jonassen, I.
10.1101/2022.08.13.503587 — bioinformatics — Posted on 2024-04-17
2288 Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4
Ravala, S. K.; Adame-Garcia, S. R.; Li, S.; Chen, C.-L.; Cianfrocco, M. A.; Gutkind, J. S.; Cash, J. N.; Tesmer, J. J. G.
10.1101/2023.09.15.557836 — biochemistry — Posted on 2024-04-17
2290 Principles of chromosome organization for meiotic recombination
Biot, M.; Toth, A.; Brun, C.; Guichard, L.; de Massy, B.; GREY, C.
10.1101/2024.03.06.583329 — molecular biology — Posted on 2024-04-17
2292 Newly synthesized mRNA selectively escapes translational repression following acute stress.
Zedan, M.; Schürch, A. P.; Heinrich, S.; Gomez-Garcia, P. A.; Khawaja, S.; Weis, K.
10.1101/2024.04.14.589419 — molecular biology — Posted on 2024-04-17
2293 The scheduling of adolescence with Netrin-1 and UNC5C
Hoops, D.; Kyne, R. F.; Salameh, S.; Avramescu, R. G.; MacGowan, D.; Ewing, E.; He, A. T.; Orsini, T.; Durand, A.; Popescu, C.; Zhao, J. M.; Schatz, K. C.; Lin, L.; Carroll, Q. E.; Liu, G.; Paul, M. J.; Flores, C.
10.1101/2023.01.19.521267 — neuroscience — Posted on 2024-04-17
2295 Human adherent cortical organoids in a multiwell format
van der Kroeg, M.; Bansal, S.; Unkel, M.; Smeenk, H.; Kushner, S. A.; de Vrij, F. M.
10.1101/2024.04.15.589507 — neuroscience — Posted on 2024-04-17
2296 Brain substates induced by DMT relate to sympathetic output and meaningfulness of the experience
Pasquini, L.; Simon, A.; Gallen, C.; Kettner, H.; Roseman, L.; Gazzaley, A.; Carhart-Harris, R.; Timmermann, C.
10.1101/2024.02.14.580356 — neuroscience — Posted on 2024-04-17
2298 Targeted protein degradation systems to enhance Wnt signaling
Sampathkumar, P.; Jung, H.; Chen, H.; Zhang, Z.; Suen, N.; Yang, Y.; Huang, Z.; Lopez, T.; Benisch, R.; Lee, S.-J.; Ye, J.; Yeh, W.-C.; Li, Y.
10.1101/2023.12.08.570758 — synthetic biology — Posted on 2024-04-17
2299 Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
Porozhan, Y.; Carstensen, M.; Thouroude, S.; Costallat, M.; Rachez, C.; Batsche, E.; Petersen, T.; Christensen, T.; Muchardt, C.
10.1101/2023.11.24.568591 — genomics — Posted on 2024-04-17
2300 Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging
Tsai, Y.-T.; Seymen, N.; Thompson, I. R.; Zou, X.; Mumtaz, W.; Gerlevik, S.; Mufti, G. J.; Karimi, M. M.
10.1101/2024.02.09.579582 — genomics — Posted on 2024-04-17
2301 Interpretable and predictive models to harness the life science data revolution
Jahner, J. P.; Buerkle, C. A.; Gannon, D. G.; Grames, E. M.; McFarlane, S. E.; Siefert, A.; Bell, K. L.; DeLeo, V. L.; Forister, M. L.; Harrison, J. G.; Laughlin, D. C.; Patterson, A. C.; Powers, B. F.; Werner, C. M.; Oleksy, I. A.
10.1101/2024.03.15.585297 — genomics — Posted on 2024-04-17
2302 Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes
Huguet, G.; Renne, T.; Poulain, C.; Dubuc, A.; Kumar, K.; Kazem, S.; Engchuan, W. B.; Shanta, O.; Douard, E.; Proulx, C.; Jean-Louis, M.; Saci, Z.; Mollon, J.; Schultz, L. M.; Knowles, E. E.; Cox, S. R.; Porteous, D.; Davies, G.; Redmond, P.; Harris, S. E.; Schumann, G.; Dumas, G.; Labbe, A.; Pausova, Z.; Paus, T.; Scherer, S. W.; Sebat, J.; Almasy, L.; Glahn, D. C.; Jacquemont, S.
10.1101/2024.04.16.589618 — genetics — Posted on 2024-04-17
2303 Long-term climatic stability drives accumulation and maintenance of divergent lineages in a temperate biodiversity hotspot
Buckley, S. J.; Brauer, C. J.; Unmack, P. J.; Hammer, M. P.; Adams, M.; Beatty, S. J.; Morgan, D. L.; Beheregaray, L. B.
10.1101/2023.03.08.531828 — evolutionary biology — Posted on 2024-04-17
2304 Dynamic Interplay of Autophagy and Membrane Repair During Mycobacterium tuberculosis Infection
Augenstreich, J.; Phan, A. T.; Allen, C. N. S.; Poddar, A.; Srinivasan, L.; Briken, V.
10.1101/2022.12.19.521111 — cell biology — Posted on 2024-04-17
2305 Bacterial pathogens dynamic during multi-species infections
Barny, M.-A.; Thieffry, S.; Gomes de Faria, C.; Thebault, E.; Pedron, J.
10.1101/2023.12.06.570389 — microbiology — Posted on 2024-04-17
2309 Infant low-frequency EEG cortical power, cortical tracking and phase-amplitude coupling predicts language a year later.
Attaheri, A.; Ni Choisdealbha, A.; Rocha, S.; Brusini, P.; Di Liberto, G. M.; Mead, N.; Olawole-Scott, H.; Boutris, P.; Gibbon, S.; Williams, I.; Grey, C.; Alfaro e Oliveira, M.; Brough, C.; Flanagan, S.; Goswami, U.
10.1101/2022.11.02.514963 — neuroscience — Posted on 2024-04-17
2310 Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.
Schmitd, L. B.; Hafner, H.; Ward, A.; Adib, E. A.; Biscola, N. P.; Kohen, R.; Patel, M.; Williamson, R. E.; Desai, E.; Bennett, J.; Saxman, G.; Athaiya, M.; Wilborn, D.; Shumpert, J.; Zhao, X.-F.; Kawaguchi, R.; Geschwind, D. H.; Hoke, A.; Shrager, P.; Collins, C. A.; Havton, L. A.; Kalinski, A. L.; Giger, R. J.
10.1101/2024.03.04.583374 — neuroscience — Posted on 2024-04-17
2311 An adaptable, reusable, and light implant for chronic Neuropixels probes
Bimbard, C.; Takacs, F.; Catarino, J. A.; Fabre, J. M.; Gupta, S.; Lenzi, S. C.; Melin, M. D.; O'Neill, N.; Orsolic, I.; Robacha, M.; Street, J. S.; Teixeira, J.; Townsend, S.; van Beest, E. H.; Zhang, A. M.; Churchland, A. K.; Duan, C. A.; Harris, K. D.; Kullmann, D. M.; Lignani, G.; Mainen, Z. F.; Margrie, T. W.; Rochefort, N. L.; Wikenheiser, A. M.; Carandini, M.; Coen, P.
10.1101/2023.08.03.551752 — neuroscience — Posted on 2024-04-17
2312 Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked to β-amyloid deposition and lysyl oxidase.
Ventura-Antunes, L.; Nackenoff, A.; Romero-Fernandez, W.; Bosworth, A. M.; Prusky, A.; Wang, E.; Carvajal-Tapia, C.; Shostak, A.; Harmsen, H.; Mobley, B.; Maldonado, J.; Solopova, E.; Snider, J. C.; Merryman, W. D. D.; Lippmann, E.; Schrag, M.
10.1101/2024.03.08.583563 — neuroscience — Posted on 2024-04-17
2313 Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish
Dasgupta, A.; Reagor, C. C.; Paik, S. P.; Snow, L. M.; Jacobo, A.; Hudspeth, A.
10.1101/2022.11.17.516962 — neuroscience — Posted on 2024-04-17
2314 Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits
Hardikar, S.; Mckeown, B.; Schaare, H. L.; Wallace, R. S.; Xu, T.; Lauckner, M.; Valk, S.; Margulies, D.; Turnbull, A.; Bernhardt, B.; Vos de Wael, R.; Villringer, A.; smallwood, j.
10.1101/2022.10.11.511591 — neuroscience — Posted on 2024-04-17
2319 Harnessing full-text publications for deep insights into C. elegans and Drosophila connectomes
ARULPRAKASAM, K. R.; TOH, J. W. S.; FOO, H.; KUMAR, M. R.; KUTEVSKA, A.-N.; DAVEY, E. E.; MUTIL, M.; THIBAULT, G.
10.1101/2024.04.13.588993 — bioinformatics — Posted on 2024-04-17
2321 β-glucan induced trained immunity enhances antibody levels in a vaccination model in mice
Ajit, J.; Chen, Q.; Ung, T.; Rosenberger, M. G.; Kim, J.; Solanki, A.; Shen, J.; Esser-Kahn, A. P.
10.1101/2024.04.11.588932 — immunology — Posted on 2024-04-17
2324 Utility of Cellular Measurements of Non-Specific Endocytosis to Assess the Target-Independent Clearance of Monoclonal Antibodies
Bryniarski, M. A.; Tuhin, M. T. H.; Shomin, C. D.; Nasrollahi, F.; Ko, C. E.; Soto, M.; Chung, K.; Poon-Andersen, C.; Primack, R.; Wong, D.; Ojeda, E.; Chung, J.; Cook, K. D.; Conner, K. P.
10.1101/2024.04.16.589824 — biochemistry — Posted on 2024-04-16
2325 Aldehydic load as an objective imaging biomarker of mild traumatic brain injury
Kirby, A.; Ward, C.; Calvert, N. D.; Daniel, R.; Leung, J. W.-H.; Shawma, A.; Suchy, M.; Donatelli, C.; Wang, J.; Standen, E.; Shuhendler, A. J.
10.1101/2024.04.16.589820 — biochemistry — Posted on 2024-04-16
2326 Proteome of human glioblastoma and meningioma tissue small extracellular vesicles
Su, H.; Purnianto, A.; Kaye, A.; Morokoff, A.; Drummond, K. j.; Stylli, S.; Vella, L. J.
10.1101/2024.04.15.589661 — biochemistry — Posted on 2024-04-16
2333 Characterising the Modulatory Role of Ikebana in Flower-Dependent Cell Competition
Marques-Reis, M.; Gutierrez-Garcia, A.; Flores Clara, C.; Argudo, I.; Stefan Eggel, M.; Hauert, B.; Bras-Pereira, C.; Moreno, E.
10.1101/2024.04.13.589362 — cell biology — Posted on 2024-04-16
2334 Transcriptome-wide mRNA condensation precedes stress granule formation and excludes stress-induced transcripts
Glauninger, H.; Bard, J. A. M.; Wong Hickernell, C. J.; Airoldi, E. M.; Li, W.; Singer, R. H.; Paul, S.; Fei, J.; Sosnick, T. R.; Wallace, E. W. J.; Drummond, D. A.
10.1101/2024.04.15.589678 — cell biology — Posted on 2024-04-16
2336 Cell cycle-dependent mRNA localization in P-bodies
SAFIEDDINE, A.; Benassy, M.-N.; Bonte, T.; Slimani, F.; Pourcelot, O.; Kress, M.; Ernoult-Lange, M.; Courel, M.; Coleno, E.; Imbert, A.; Laine, A.; Munier Godebert, A.; Vinit, A.; Blugeon, C.; Chevreux, G.; Gautheret, D.; Walter, T.; Bertrand, E.; Benard, M.; Weil, D.
10.1101/2024.04.16.589748 — cell biology — Posted on 2024-04-16
2338 Geranylgeranylated-SCFFBXO10 Regulates Selective Outer Mitochondrial Membrane Proteostasis and Function
Bhat, S. A.; Vasi, Z.; Jiang, L.; Selvaraj, S.; Ferguson, R.; Gudur, A.; Ismail, H.; Adhikari, R.; Dhabaria, A.; Ueberheide, B.; Kuchay, S.
10.1101/2024.04.16.589745 — cell biology — Posted on 2024-04-16
2340 A fine kinetic balance of interactions directs transcription factor hubs to genes
Mukherjee, A.; Fallacaro, S.; Ratchasanmuang, P.; Zinski, J.; Boka, A.; Shankta, K.; Mir, M.
10.1101/2024.04.16.589811 — molecular biology — Posted on 2024-04-16
2346 Markov Field network integration of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques
Wang, S.; Myers, A.; Irvine, E. B.; Wang, C.; Maiello, P.; Rodgers, M.; Tomko, J.; Kracinovsky, K.; Borish, H. J.; Chao, M. C.; Mugahid, D.; Darrah, P. A.; Seder, R. A.; Roederer, M.; Scanga, C.; Lin, P. L.; Alter, G.; Fortune, S. M.; Flynn, J. L.; Lauffenburger, D. A.
10.1101/2024.04.13.589359 — systems biology — Posted on 2024-04-16
2348 The Natural Material Evolution and Stage-wise Assembly of Silk Along the Silk Gland
Brookstein, O.; Shimoni, E.; Eliaz, D.; Dezorella, N.; Biran, I.; Rechav, K.; Sivan, E.; Kozell, A.; Shimanovich, U.
10.1101/2024.04.16.589504 — biochemistry — Posted on 2024-04-16
2349 Comprehensive Analysis of Nascent Transcriptome Reveals Diverse Transcriptional Profiles Across the Trypanosoma cruzi Genome Underlining the Regulatory Role of Genome Organization, Chromatin Status, and Cis-Acting Elements
Carvalho de Lima, P. L.; de Sousa Lopes, L.; Nunes Roson, J.; Borges, A.; Karla Bellini, N.; Carolina Tahira, A.; Santos da Silva, M.; da Silva Pires, D.; Quartim Barbosa Elias, M. C.; da Cunha, J. P. C.
10.1101/2024.04.16.589700 — molecular biology — Posted on 2024-04-16
2351 Tetracistronic Minigenomes Elucidate a Functional Promoter for Ghana Virus and Unveils Cedar Virus Replicase Promiscuity for all Henipaviruses
Haas, G. D.; Schmitz, K. S.; Azarm, K. D.; Johnson, K. N.; Klain, W. R.; Freiberg, A. N.; Cox, R. M.; Plemper, R. K.; Lee, B.
10.1101/2024.04.16.589704 — microbiology — Posted on 2024-04-16
2354 T follicular helper cell profiles differ by malaria antigen and for children compared to adults
Forconi, C. S.; Nixon, C.; Wu, H. W.; Odwar, B.; Pond-Tor, S.; Ong'echa, J. M.; Kurtis, J. D.; Moormann, A. M.
10.1101/2024.04.13.589352 — immunology — Posted on 2024-04-16
2355 Label-free structural imaging of plant roots and microbes using third- harmonic generation microscopy
Pan, D.; Rivera, J. A.; Kim, P.; Miao, M.; Tyml, T.; Rodriguez, C.; Wang, B.; Yoshikuni, Y.; Elisabeth, N. H.; Northen, T.; Vogel, J. P.; Ji, N.
10.1101/2024.04.13.589377 — plant biology — Posted on 2024-04-16
2357 Wax "tails" enable planthopper nymphs to self-right midair and land on their feet
McDonald, C. L.; Alcalde, G. T.; Jones, T. C.; Laude, R. A. P.; Yap, S. A.; Bhamla, M. S.
10.1101/2024.04.15.589523 — bioengineering — Posted on 2024-04-16
2358 Development and Implementation of a Core Genome Multilocus Sequence Typing (cgMLST) scheme for Haemophilus influenzae
Krisna, M. A.; Jolley, K. A.; Monteith, W.; Boubour, A.; Hamers, R. L.; Brueggemann, A. B.; Harrison, O. B.; Maiden, M. C. J.
10.1101/2024.04.15.589521 — genomics — Posted on 2024-04-16
2359 Chromosome-level baobab (Adansonia digitata) genome illuminates its evolutionary insights
Kitony, J. K.; Colt, K.; Abra, B. W.; Hartwick, N. T.; Petrus, S.; Konozy, E. H.; Karimi, N.; Yant, L.; Michael, T. P.
10.1101/2024.04.14.589434 — genomics — Posted on 2024-04-16
2360 Investigative power of Genomic Informational Field Theory (GIFT) relative to GWAS for genotype-phenotype mapping
Kyratzi, P.; Matika, O.; Brassington, A. H.; Connie, C. E.; Xu, J.; Barrett, D. A.; Emes, R. D.; Archibald, A. L.; Paldi, A.; Sinclair, K. D.; Wattis, J.; Rauch, C.
10.1101/2024.04.16.589524 — genetics — Posted on 2024-04-16
2362 Microsaccade Selectivity as Discriminative Feature for Object Decoding
Nouri, S.; Soltani Tehrani, A.; Faridani, N.; Toosi, R.; Dehaqani, M.-R. A.
10.1101/2024.04.13.589338 — neuroscience — Posted on 2024-04-16
2363 GoMartini 3: From large conformational changes in proteins to environmental bias corrections
Souza, P. C. T.; Borges Araujo, L. P.; Brasnett, C.; Moreira, R. A.; Grunewald, F.; Park, P.; Wang, L.; Razmazma, H.; Borges-Araujo, A. C.; Cofas-Vargas, L. F.; Monticelli, L.; Mera-Adasme, R.; Melo, M. N.; Wu, S.; Marrink, S. J.; Poma, A. B.; Thallmair, S.
10.1101/2024.04.15.589479 — biophysics — Posted on 2024-04-16
2365 Genotyping of paired clinical isolates using PvCSP, PvMSP3α PvMSP3βand exploring STRs to differentiate between relapse and reinfection in P. vivax
Savargaonkar, D.; Gahtori, R.; Sinha, S.; Kumari, P.; Mahale, P.; Srivastava, B.; Pande, V.; Pawar, H. S.; Anvikar, A. R.
10.1101/2024.04.16.589389 — genomics — Posted on 2024-04-16
2367 Discovery of shared epigenetic pathways across human phenotypes
Kratschmer, I.; Smith, H. M.; McCartney, D. L.; Bernabeu, E.; Mahmoudi, M.; Campbell, A. L.; Corley, J.; Harris, S.; Cox, S. R.; Marioni, R. R.; Robinson, M. R.
10.1101/2024.04.15.589547 — genetics — Posted on 2024-04-16
2371 A self-cooling self-humidifying mosquito carrier backpack for transporting live adult mosquitoes on foot over long distances under challenging field conditions.
Kavishe, D. R.; Msoffe, R. V.; Malika, G. Z.; Walsh, K. A.; Duggan, L. M.; Tarimo, L. J.; Butler, F.; Kaindoa, E. W. W.; Ngowo, H. S.; Killeen, G.
10.1101/2024.04.13.588955 — ecology — Posted on 2024-04-16
2372 Multi-Omics after O-GlcNAc Alteration Identifies Cellular Processes Working Synergistically to Promote Aneuploidy
Boyd, S.; Robarts, D.; Nguyen, K.; Villar, M.; Alghusen, I.; Kotulkar, M.; Denson, A.; Fedoosyuk, H.; Lee, N.; Whelan, S. A.; Hanover, J. A.; Dias, W.; Tan, E. P.; McGreal, S.; Artigues, A.; Swerdlow, R. H.; Thompson, J.; Apte, U.; Slawson, C.
10.1101/2024.04.16.589379 — cell biology — Posted on 2024-04-16
2373 Aging shapes infection profiles of influenza A virus and SARS-CoV-2 in human lung slices
Bruegger, M.; Machahua, C.; Zumkehr, B.; Cismaru, C.; Jandrasits, D.; Dorn, P.; Marti, T.; Zimmer, G.; Thiel, V.; Funke-Chambour, M.; Alves, M. P.
10.1101/2024.04.14.589423 — microbiology — Posted on 2024-04-16
2374 Highly Pathogenic Avian Influenza A (H5N1) clade 2.3.4.4b Virus detected in dairy cattle
Hu, X.; Saxena, A.; Magstadt, D. R.; Gauger, P. C.; Burrough, E.; Zhang, J.; Siepker, C.; Mainenti, M.; Gorden, P.; Plummer, P.; Li, G.
10.1101/2024.04.16.588916 — microbiology — Posted on 2024-04-16
2376 A transcriptome atlas of zygotic and somatic embryogenesis in Norway spruce
Stojkovic, K.; Canovi, C.; Le, K.-C.; Delhomme, N.; Egertsdotter, U.; Street, N. R.
10.1101/2024.04.13.589382 — plant biology — Posted on 2024-04-16
2381 Genetic and anatomical determinants of olfaction in dogs and wild canids
Mouton, A.; Bird, D.; Li, G.; Craven, B. A.; Levine, J. M.; Morselli, M.; Pellegrini, M.; Van Valkenburgh, B.; Wayne, R. K.; Murphy, W. J.
10.1101/2024.04.15.589487 — evolutionary biology — Posted on 2024-04-16
2382 Human adherent cortical organoids in a multiwell format
van der Kroeg, M.; Bansal, S.; Unkel, M. A.; Smeenk, H.; Kushner, S. A.; de Vrij, F. M.
10.1101/2024.04.15.589507 — neuroscience — Posted on 2024-04-16
2383 AUTS2, a causative gene for microcephaly, regulates division of intermediate progenitor cells and production of upper-layer neurons
Shimaoka, K.; Hori, K.; Miyashita, S.; Inoue, Y. U.; Sakamoto, A.; Hasegawa, I.; Yamashiro, K.; Egusa, S. F.; Tatsumoto, S.; Go, Y.; Abe, M.; Sakimura, K.; Inoue, T.; Imamura, T.; Hoshino, M.
10.1101/2024.04.15.589462 — neuroscience — Posted on 2024-04-16
2384 Single-nuclei histone modification profiling of the adult human central nervous system unveils epigenetic memory of developmental programs
Kabbe, M.; Agirre, E.; Carlstrom, K. E.; Baldivia Pohl, F.; Ruffin, N.; van Bruggen, D.; Meijer, M.; Seeker, L. A.; Bestard-Cuche, N.; Lederer, A. R.; Zhang, J.; Ahola, V.; Goldman, S. A.; Bartosovic, M.; Jagodic, M.; Williams, A.; Castelo-Branco, G.
10.1101/2024.04.15.589512 — neuroscience — Posted on 2024-04-16
2387 A spatio-temporaral atlas of the growing brain for fMRI studies
Deprez, M. M.; Doria, V.; Srinivasan, L.; Aljabar, P.; Edwards, D.; Rueckert, D.
10.1101/2024.04.15.589560 — neuroscience — Posted on 2024-04-16
2389 Antimicrobial blue light-bathing therapy for wound infection control
Hui, J.; Moon, W.; Dong, P.-T.; dos Anjos, C.; Negri, L.; Yan, H.; Wang, Y.; Tam, J.; Dai, T.; Anderson, R. R.; Goverman, J.; Gelfand, J.; Yun, S.-H.
10.1101/2024.04.13.589323 — bioengineering — Posted on 2024-04-16
2390 Poseidon - A framework for archaeogenetic human genotype data management
Schmid, C.; Ghalichi, A.; Lamnidis, T. C.; Athanayaka Mudiyanselage, D. B.; Haak, W.; Schiffels, S.
10.1101/2024.04.12.589180 — genetics — Posted on 2024-04-16
2391 A multistate capture-recapture model to estimate reproduction of North Atlantic right whales
Linden, D. W.; Pace, R. M.; Garrison, L. P.; Hostetler, J. A.; Knowlton, A. R.; Lesage, V.; Williams, R.; Runge, M. C.
10.1101/2024.04.13.589367 — ecology — Posted on 2024-04-16
2393 Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice
Lei, Z.; Zhai, S.; Yuan, X.; Wang, R.; Wang, P.; Pandey, V.; Zhang, C. Y.; Ji, J.; Yu, D.; Chen, Z.; Bian, S.; Qin, P.
10.1101/2023.11.05.565350 — immunology — Posted on 2024-04-16
2394 Inhibitory control of locomotor statistics in walking Drosophila
Gattuso, H.; Nunez, K. M.; de la Rea, B.; Ermentrout, B.; Victor, J. D.; Nagel, K. I.
10.1101/2024.04.15.589655 — neuroscience — Posted on 2024-04-16
2396 Repression of pattern-triggered immune responses by hypoxia
Mooney, B. C.; Doorly, C. M.; Mantz, M.; Garcia, P.; Huesgen, P. F.; Graciet, E.
10.1101/2023.11.07.565979 — plant biology — Posted on 2024-04-16
2398 MC1R reduces scarring and rescues stalled healing in a preclinical chronic wound model
Nawilaijaroen, Y.; Rocliffe, H. R.; Austin-Williams, S.; Krilis, G.; Pellicoro, A.; Zhou, K.; Ji, Y.; Bain, C.; Kilpatrick, A. M.; Chen, Y.; Crichton, M.; Huang, Z.; Forbes, S. J.; Caporali, A.; Cash, J. L.
10.1101/2022.11.30.518516 — pathology — Posted on 2024-04-16
2400 The recombination landscape of the barn owl, from families to populations
Topaloudis, A.; Lavanchy, E.; Cumer, T.; Ducrest, A.-L.; Simon, C.; Machado, A. P.; Paposhvili, N.; Roulin, A.; Goudet, J.
10.1101/2024.04.11.589103 — genomics — Posted on 2024-04-16
2404 Metabolically intact nuclei are fluidized by the activity of the chromatin remodeling motor BRG1
Byfield, F.; Eftekhari, B.; Kaymak-Loveless, K.; Mandal, K.; Li, D.; Wells, R. G.; Chen, W.; Brujic, J.; Bergamasschi, G.; wuite, G. G.; Patteson, A. E.; Janmey, P. A.
10.1101/2024.04.12.589275 — cell biology — Posted on 2024-04-16
2406 Detection and spread of high pathogenicity avian influenza virus H5N1 in the Antarctic Region
Bennison, A.; Byrne, A. M.; Reid, S. M.; Lynton-Jenkins, J. G.; Mollett, B.; De Sliva, D.; Peers-Dent, J.; Finlayson, K. E.; Hall, R.; Blockley, F.; Blyth, M.; Falchieri, M.; Fowler, Z.; Fitzcharles, E.; Brown, I. H.; James, J.; Banyard, A. C.
10.1101/2023.11.23.568045 — microbiology — Posted on 2024-04-16
2407 Queuosine Salvage in Bartonella henselae Houston 1: A Unique Evolutionary Path
Quaiyum, S.; Yuan, Y.; Sun, G.; Ratnayake, M.; Hutinet, G.; Dedon, P. C.; Minnick, M. F.; de Crecy-Lagard, V.
10.1101/2023.12.05.570228 — microbiology — Posted on 2024-04-16
2408 CD4-mediated immunity shapes neutrophil-driven tuberculous pathology
Gern, B. H.; Klas, J. M.; Foster, K. A.; Cohen, S. B.; Plumlee, C. R.; Duffy, F. J.; Neal, M. L.; Halima, M.; Gustin, A. T.; Diercks, A. H.; Aderem, A.; Gale, M.; Aitchison, J. D.; Gerner, M. Y.; Urdahl, K. B.
10.1101/2024.04.12.589315 — immunology — Posted on 2024-04-16
2409 Regulation of host metabolism and defense strategies to survive neonatal infection
Wu, Z.; Tien, N. T. N.; Baek, O.; Zhong, J.; Klabunde, B.; Nguyen, T. T.; Yen, N. T. H.; Long, N. P.; Nguyen, D. N.
10.1101/2024.02.23.581534 — immunology — Posted on 2024-04-16
2410 Adolescent chronic sleep restriction promotes alcohol drinking in adulthood: evidence from epidemiological and preclinical data.
Faniyan, O. O.; Marcotulli, D.; Simayi, R.; Del Gallo, F.; De Carlo, S.; Ficiara, E.; Caramaschi, D.; Richmond, R.; Franchini, D.; Bellesi, M.; Ciccocioppo, R.; de Vivo, L.
10.1101/2023.10.11.561858 — neuroscience — Posted on 2024-04-16
2412 luxA gene from Enhygromyxa salina encodes a functional homodimeric luciferase
Yudenko, A.; Bazhenov, S. V.; Aleksenko, V. A.; Goncharov, I. M.; Semenov, O.; Remeeva, A.; Nazarenko, V. V.; Kuznetsova, E.; Fomin, V. V.; Konopleva, M. N.; Al Ebrahim, R.; Sluchanko, N. N.; Ryzhykau, Y.; Semenov, Y. S.; Kuklin, A.; Manukhov, I. V.; Gushchin, I.
10.1101/2023.02.27.530324 — biochemistry — Posted on 2024-04-16
2413 Levy statistics define anxiety and depression in mice subjected to chronic stress
Li, Q.; Nie, Y.; Li, X.; Luo, Y.; Zhao, B.; Zhang, N.; Kuang, W.; Tian, C.; Chen, D.; Zhang, Y.; Wu, Z.; Zhong, Z.
10.1101/2023.06.18.545232 — animal behavior and cognition — Posted on 2024-04-16
2414 Inference of Locus-Specific Population Mixtures From Linked Genome-Wide Allele Frequencies
Reyna-Blanco, C. S.; Caduff, M.; Galimberti, M.; Leuenberger, C.; Wegmann, D.
10.1101/2023.11.06.565831 — genomics — Posted on 2024-04-16
2418 Regulation of host metabolism and defense strategies to survive neonatal infection
Wu, Z.; Tien, N. T. N.; Baek, O.; Zhong, J.; Klabunde, B.; Tinh Thu, N.; Yen, N. T. H.; Long, N. P.; Nguyen, D. N.
10.1101/2024.02.23.581534 — immunology — Posted on 2024-04-16
2421 The neonicotinoid acetamiprid is highly toxic to wild non-target insects
Sedlmeier, J. E.; Grass, I.; Bendalam, P.; Hoeglinger, B.; Walker, F.; Gerhard, D.; Piepho, H.-P.; Bruehl, C. A.; Petschenka, G.
10.1101/2024.04.11.589033 — ecology — Posted on 2024-04-16
2424 Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling
Griffiths, S. C.; Tan, J.; Wagner, A.; Blazer, L. L.; Adams, J. J.; Srinivasan, S.; Moghisaei, S.; Sidhu, S. S.; Siebold, C.; Ho, H.-Y. H.
10.1101/2021.07.26.453829 — biochemistry — Posted on 2024-04-15
2425 Recent emergence of cephalosporin resistant Salmonella Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding blaCTX-M-15 gene
Thirumoorthy, T. P.; Jacob, J. J.; V, A.; T, M. P.; Shah, B. S.; Iyer, V.; Maheshwari, G.; Trivedi, U.; Shah, A.; Patel, P.; Gaigawale, A.; M, Y.; Sathya Narayanan, P.; Mutreja, A.; Carey, M.; John, J.; Kang, G.; Veeraraghavan, B.
10.1101/2023.07.05.547856 — genomics — Posted on 2024-04-15
2426 Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension
Liu, B.; Yi, D.; Li, S.; Ramirez, K.; Xia, X.; Cao, Y.; Zhao, H.; Tripathi, A.; Qiu, S.; Kala, M.; Rafikov, R.; Gu, H.; Perez, V. d. j.; Lemay, S.-E.; Glembotski, C. C.; Knox, K. S.; Kalinichenko, V. V.; Bonnet, S.; Zhao, Y.; Fallon, M. B.; Boucherat, O.; Dai, Z.
10.1101/2024.02.11.579846 — molecular biology — Posted on 2024-04-15
2428 Spyglass: a framework for reproducible and shareable neuroscience research
Lee, K. H.; Denovellis, E. L.; Ly, R.; Magland, J.; Soules, J.; Comrie, A. E.; Gramling, D. P.; Guidera, J. A.; Nevers, R.; Adenekan, P.; Brozdowski, C.; Bray, S. R.; Monroe, E.; Bak, J. H.; Coulter, M.; Sun, X.; Broyles, E.; Shin, D.; Chiang, S.; Holobetz, C.; Tritt, A.; Ruebel, O.; Nguyen, T.; Yatsenko, D.; Chu, J.; Kemere, C.; Garcia, S.; Buccino, A.; Frank, L. M.
10.1101/2024.01.25.577295 — neuroscience — Posted on 2024-04-15
2432 Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma
Lipchick, B.; Guterres, A. N.; Chen, H.-Y.; Zundell, D. M.; Del Aguila, S.; Reyes-Uribe, P. I.; Basu, S.; Yin, X.; Kossenkov, A. V.; Lu, Y.; Mills, G. B.; Liu, Q.; Goldman, A. R.; Murphy, M. E.; Speicher, D. W.; Villanueva, J.
10.1101/2021.04.07.438684 — cancer biology — Posted on 2024-04-15
2433 Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring
Gadeberg, T. A.; Joergensen, M. H.; Olesen, H. G.; Lorentzen, J.; Harwood, S. L.; Almeida, A. V.; Fruergaard, M. U.; Jensen, R. K.; Kanis, P.; Pedersen, H.; Tranchant, E.; Petersen, S. V.; Thoegersen, I. B.; Lyons, J. A.; Enghild, J. J.; Andersen, G. R. R.
10.1101/2024.04.15.589532 — biochemistry — Posted on 2024-04-15
2435 Subcellular, biochemical and biophysical alterations in two glial cell models of ARSACS
Murtinheira, F.; Boasinha, A. S.; Belo, J.; Macedo, L.; Farsetti, E.; Robalo, T. T.; Torres, V. M.; Pinto, F. R.; Fernandes, A.; Nascimento, P.; Rodrigues, M. S.; Herrera, F.
10.1101/2024.04.15.589510 — biochemistry — Posted on 2024-04-15
2441 Quantitative assessment of strain isolates and microbiomes using fast MS/MS-free metaproteomics
Kazakova, E. M.; Ivanov, M. V.; Kusainova, T.; Bubis, J. A.; Polivtseva, V. N.; Petrikov, K. V.; Gorshkov, V.; Kjeldsen, F.; Gorshkov, M. V.; Delegan, Y. A.; Solyanikova, I. P.; Tarasova, I. A.
10.1101/2024.04.15.589175 — microbiology — Posted on 2024-04-15
2444 Disruption of Cholinergic Retinal Waves Alters Visual Cortex Development and Function
Burbridge, T. J.; Ratliff, J. M.; Dwivedi, D.; Vrudhula, U.; Alvarado-Huerta, F.; Sjulson, L.; Ibrahim, L. A.; Cheadle, L.; Fishell, G.; Batista-Brito, R.
10.1101/2024.04.05.588143 — neuroscience — Posted on 2024-04-15
2446 The spatiotemporal richness of hummingbird wing deformations
Skandalis, D. A.; Baliga, V. B.; Goller, B.; Altshuler, D. L.
10.1101/2023.05.08.539717 — zoology — Posted on 2024-04-15
2448 The Zea mays PeptideAtlas; a new maize community resource
van Wijk, K. J.; Leppert, T.; Sun, Z.; Guzchenko, I.; Debley, E.; Sauermann, G.; Routray, P.; Mendoza, L.; Sun, Q.; Deutsch, E. W.
10.1101/2023.12.21.572651 — plant biology — Posted on 2024-04-15
2449 Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels
Budde, I.; Schlichting, A.; Ing, D.; Schimmelpfennig, S.; Kuntze, A.; Fels, B.; Romac, J. M.-J.; Swain, S. M.; Liddle, R. A.; Stevens, A.; Schwab, A.; Petho, Z.
10.1101/2023.12.22.572956 — physiology — Posted on 2024-04-15
2452 S-Wipe: stool sample collection for metabolomic gut health tracking
Melnik, A. V.; Pobozhev, K.; Lotfi, A.; Moradi, D.; Monahan, H.; Kopylova, E.; Aksenov, A. A.
10.1101/2024.04.12.589313 — biochemistry — Posted on 2024-04-15
2455 Discovering non-additive heritability using additive GWAS summary statistics
Smith, S. P.; Darnell, G.; Udwin, D.; Stamp, J.; Harpak, A.; Ramachandran, S.; Crawford, L.
10.1101/2022.07.21.501001 — genomics — Posted on 2024-04-15
2457 The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)
Chen, J.; Yap, M. C.; Bassot, A.; Pascual, D. M.; Makio, T.; Zimmermann, J.; Mast, H.; Bhat, R.; Fleury, S. G.; Fan, Y.; Zardini Buzatto, A.; Moore, J.; Ballanyi, K.; Li, L.; Overduin, M.; Lemieux, M. J.; Lemieux, H.; Tan, W.-H.; Mancini, G. M. S.; Morgan, B.; Marcogliese, P. C.; Simmen, T.
10.1101/2024.04.12.589228 — cell biology — Posted on 2024-04-15
2458 Nuclear basket proteins regulate the distribution and mobility of nuclear pore complexes in budding yeast
Zsok, J.; Simon, F.; Bayrak, G.; Isaki, L.; Kerff, N.; Wolstenholme, A.; Weiss, L. E.; Dultz, E.
10.1101/2023.09.28.558499 — cell biology — Posted on 2024-04-15
2459 Associations between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach
Couvillion, S. P.; Nakayasu, E. S.; Webb-Robertson, B.-J.; Yang, I.; Eder, J.; Nicora, C. D.; Bramer, L. M.; Gao, Y.; Fox, A.; DeCarlo, C.; Yang, X.; Zhou, M.; Pace, R. M.; Williams, J. E.; McGuire, M. A.; McGuire, M.; Metz, T.; Powell, R. L. R.
10.1101/2024.04.12.589299 — molecular biology — Posted on 2024-04-15
2461 Building a Collaborative DNA Barcode Library for the Diptera of Churchill, Canada: A Resource for Northern Research
Majoros, S. E.; Wang, J.; Levesque-Beaudin, V.; Borkent, C. J.; Brodo, F.; Brooks, S. E.; Boucher, S.; Cumming, J. M.; Currie, D. C.; Ekrem, T.; Elliott, T. A.; Hebert, P. D. N.; Savage, J.; Schaefer, P.; Sinclair, B. J.; Skevington, J. H.; Solecki, A. M.; Stur, E.; Wheeler, T. A.; Woodcock, T. S.; Young, A. D.; Young, C.; Adamowicz, S. J.
10.1101/2024.03.27.586819 — molecular biology — Posted on 2024-04-15
2462 SMG1:SMG8:SMG9-complex integrity maintains robustness of nonsense-mediated mRNA decay
Kueckelmann, S.; Theunissen, S.; Lackmann, J.-W.; Franitza, M.; Becker, K.; Boehm, V.; Gehring, N. H.
10.1101/2024.04.15.589496 — molecular biology — Posted on 2024-04-15
2463 Two distinct Trypanosoma eIF4F complexes co-exist, bind different mRNAs and are regulated during nutritional stress
Papini Gabiatti, B.; Ribeiro Freire, E.; Ferreira da Costa, J.; Galvao Ferrarini, M.; Reichert Assuncao de Matos, T.; Preti, H.; Munhoz da Rocha, I.; Gomes Guimaraes, B.; Kramer, S.; Ivo Tonin Zanchin, N.; Holetz, F. B.
10.1101/2024.04.15.589194 — molecular biology — Posted on 2024-04-15
2464 Characterization of spike processing and entry mechanisms of seasonal human coronaviruses NL63, 229E and HKU1
Neerukonda, S. N.; Vassell, R.; Lusvarghi, S.; Liu, S.; Akue, A.; Kukuruga, M.; Wang, T. T.; Weiss, C. D.; Wang, W.
10.1101/2024.04.12.589332 — microbiology — Posted on 2024-04-15
2471 Systematic Discovery of Phage Genes that Inactivate Bacterial Immune Systems
Ojima, S.; Azam, A. H.; Kondo, K.; Nie, W.; Wang, S.; Chihara, K.; Tamura, A.; Yamashita, W.; Nakamura, T.; Sugawara, Y.; Sugai, M.; Zhu, B.; Takahashi, Y.; Watashi, K.; Kiga, K.
10.1101/2024.04.14.589459 — microbiology — Posted on 2024-04-15
2473 Metabolic interactions underpinning high methane fluxes across terrestrial freshwater wetlands
Bechtold, E. K.; Ellenbogen, J. B.; Villa, J. A.; de Melo Ferreira, D. K.; Oliverio, A. M.; Kostka, J. E.; Rich, V. I.; Varner, R. K.; Bansal, S.; Ward, E. J.; Bohrer, G.; Borton, M. A.; Wrighton, K. C.; Wilkins, M. J.
10.1101/2024.04.15.589101 — microbiology — Posted on 2024-04-15
2474 Urine microbiome changes during and after radiotherapy for prostate cancer
Złoch, M.; Sibinska, E.; Monedeiro, F.; Mista, W.; Arendowski, A.; Fijałkowski, P.; Pietrowska, M.; Mrochem-Kwarciak, J.; Jedrzejewska, A.; Telka, E.; Karon, K.; Rabsztyn, M.; Pomastowski, P.; Gabrys, D.
10.1101/2024.04.15.589478 — microbiology — Posted on 2024-04-15
2476 EF-P and its paralog EfpL (YeiP) differentially control translation of proline containing sequences
Sieber, A. M.; Parr, M.; von Ehr, J.; Dhamotharan, K.; Kielkowski, P.; Brewer, T.; Schaepers, A.; Krafczyk, R.; Qi, F.; Schlundt, A.; Frishman, D.; Lassak, J.
10.1101/2024.04.15.589488 — microbiology — Posted on 2024-04-15
2477 Cross-reactivity of rPvs48/45, a recombinant Plasmodium vivax protein, with sera from Plasmodium falciparum endemic areas of Africa
Arevalo-Herrera, M.; Balam, S.; Miura, K.; Ayadi, I.; Konate, D.; Incandela, N. C.; Agnolon, V.; Guindo, M. A.; Diakite, S. A. S.; Olugbile, S.; Nebie, I.; Herrera, S. M.; Long, C.; Kajava, A. V.; Diakite, M.; Corradin, G.; Herrera, S.
10.1101/2024.04.10.588966 — immunology — Posted on 2024-04-15
2478 Female GluA3-KO mice show early onset hearing loss and afferent swellings in ambient sound levels
Pal, I.; Bhattacharyya, A.; V-Ghaffari, B.; Williams, E. D.; Xiao, M.; Rutherford, M. A.; Rubio, M. E.
10.1101/2024.02.21.581467 — neuroscience — Posted on 2024-04-15
2479 Cellular and Molecular Basis of Leptin Resistance
Tan, B.; Hedbacker, K.; Kelly, L.; Zhang, Z.; Luo, J.-D.; Rabinowitz, J. D.; Friedman, J. M.
10.1101/2023.08.24.554526 — neuroscience — Posted on 2024-04-15
2480 Engineering sequestration-based biomolecular classifiers with shared resources
Moghimianavval, H.; Gispert, I.; Castillo, S. R.; Corning, O. B. W. H.; Liu, A. P.; Cuba Samaniego, C.
10.1101/2024.04.15.589451 — synthetic biology — Posted on 2024-04-15
2484 Multiscale simulations of molecular recognition by phase separated MUT-16: A scaffolding protein of Mutator foci
Gaurav, K.; Busetto, V.; Moscoso, D. J. P.; Changiarath, A.; Hanson, S. M.; Falk, S.; Ketting, R. F.; Stelzl, L. S.
10.1101/2024.04.13.589337 — bioinformatics — Posted on 2024-04-15
2485 UK BioCoin: Swift Trait-Specific Summary Statistics Regression for UK Biobank
He, J.-C.; Qi, G.-A.; Ying, J.; Qian, Y.; Han, L.; Mao, Y.; Zheng, H.-F.; Jiang, H.; Chen, G.-B.
10.1101/2024.04.12.589273 — genetics — Posted on 2024-04-15
2486 Hepatitis E Virus-induced antiviral response by plasmacytoid dendritic cells is modulated by the ORF2 protein
Joshi, G.; Decembre, E.; Brocard, J.; Montpellier, C.; Ferrie, m.; Allatif, O.; Menhert, A.-K.; Pons, J.; Galiana, D.; Dao Thi, V. L.; Jouvenet, N.; Cocquerel, L.; Dreux, M.
10.1101/2024.04.12.589258 — immunology — Posted on 2024-04-15
2488 Robust self-supervised denoising of voltage imaging data using CellMincer
Wang, B.; Ma, T.; Chen, T.; Nguyen, T.; Crouse, E.; Fleming, S. J.; Walker, A. S.; Valakh, V.; Nehme, R.; Miller, E. W.; Farhi, S. L.; Babadi, M.
10.1101/2024.04.12.589298 — neuroscience — Posted on 2024-04-15
2489 Spatial chemistry of citrus reveals molecules bactericidal to Candidatus Liberibacter asiaticus
Aksenov, A. A.; Blacutt, A.; Ginnan, N.; Rolshausen, P.; Melnik, A. V.; Lotfi, A.; Gentry, E. C.; Ramasamy, M.; Zuniga, C.; Zengler, K.; Mandadi, K.; Dorrestein, P. C.; Roper, C.
10.1101/2024.04.12.589303 — plant biology — Posted on 2024-04-15
2490 Unlocking TAS2R14 activation through intricate multi-ligand binding networks
Hu, X.; Ao, W.; Gao, M.; Wu, L.; Pei, Y.; Liu, S.; Sun, Q.; Liu, J.; Jiang, L.; Wu, Y.; Wang, X.; Li, Y.; Tan, Q.; Cheng, J.; Yang, F.; Yang, C.; Sun, J.; Hua, T.; Liu, Z.
10.1101/2024.04.13.589249 — biophysics — Posted on 2024-04-15
2491 Biophysical characterization of high-confidence, small human proteins
Whited, A. M.; Jungreis, I.; Allen, J.; Cleveland, C.; Mudge, J. M.; Kellis, M.; Rinn, J.; Hough, L. E.
10.1101/2024.04.12.589296 — biophysics — Posted on 2024-04-15
2494 Why is usefulness rarely useful?
Wang, F.; Feldmann, M. J.; Runcie, D. E.
10.1101/2024.04.12.589314 — genetics — Posted on 2024-04-15
2505 Automatization and validation of the hippocampal-to-ventricle ratio in a clinical sample
Fernandez-Lozano, S.; Fonov, V.; Schoemaker, D.; Pruessner, J.; Potvin, O.; Duchesne, S.; Collins, D. L.; for the Alzheimers Disease Neuroimaging Initiative,
10.1101/2024.04.12.588928 — neuroscience — Posted on 2024-04-15
2507 Free fatty acid receptor 4 in cardiac myocytes ameliorates ischemic cardiomyopathy
Zhang, M. J.; Karachenets, S.; Gyberg, D. J.; Puccini, S.; Healy, C. L.; Wu, S. C.; Shearer, G. C.; O'Connell, T. D.
10.1101/2024.04.12.589280 — physiology — Posted on 2024-04-15
2508 Mitochondria inside acute myeloid leukemia cells hydrolyze ATP to resist chemotherapy
Hagen, J. T.; Montgomery, M.; Aruleba, R.; Chrest, B.; Green, T. D.; Kassai, M.; Zeczycki, T.; Schmidt, C. A.; Bhowmick, D.; Tan, S.-F.; Feith, D.; Chalfant, C.; Loughran, T.; Liles, D.; Minden, M.; Schimmer, A.; Cabot, M.; McClung, J.; Fisher-Wellman, K.
10.1101/2024.04.12.589110 — cancer biology — Posted on 2024-04-15
2509 p53 restores the silencing of activated L1 Transposons
Paul, P.; Kumar, A.; De, A. K.; Parida, A. S.; Bhadke, G. V.; Khatua, S.; Pattanayak, F.; Tiwari, B.
10.1101/2024.04.12.589154 — cancer biology — Posted on 2024-04-15
2515 A novel method to guide biomarker combinations to optimize the sensitivity
Irajizad, E.; Long, J. P.; Do, K.-A.; Fahrmann, J.; Hanash, S.; Ghasemi, S. M.
10.1101/2024.04.12.589302 — bioinformatics — Posted on 2024-04-15
2518 Super-resolution Left Ventricular Flow and Pressure Mapping by Navier-Stokes-Informed Neural Networks
Maidu, B.; Martinez-Legazpi, P.; Guerrero-Hurtado, M.; Nguyen, C. M.; Gonzalo, A.; Kahn, A. M.; Bermejo, J.; Flores, O.; del Alamo, J. C.
10.1101/2024.04.12.589319 — bioengineering — Posted on 2024-04-15
2524 Cell wall digestibility outperforms ear in maintaining digestibility even under severe combined water and heat stress
Main, O.; Lopez-Malvar, A.; Meunier, F.; Guillaume, S.; Jacquemot, M.-P.; Lopez-Marnet, P.-L.; Barotin, C.; Marmagne, A.; Cezard, L.; Fargier, S.; Rey, S.; Larsonneau, P.; Reymond, M.; Mangel, N.; Uijttewaal, A.; Coursol, S.; Mechin, V.
10.1101/2024.04.12.589230 — plant biology — Posted on 2024-04-15
2528 Molecular responses of chicken embryos to maternal heat stress through DNA methylation and gene expression
Karami, K.; Sabban, J.; Cerutti, C.; Devailly, G.; Foissac, S.; Gourichon, D.; Hubert, A.; Hubert, J.-N.; Leroux, S.; Zerjal, T.; Lagarrigue, S.; Pitel, F.
10.1101/2024.04.12.589068 — genomics — Posted on 2024-04-15
2530 Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency
Huhn, A.; Nissley, D. A.; Wilson, D. B.; Kutuzov, M. A.; Donat, R.; Tan, T. K.; Zhang, Y.; Barton, M. I.; Liu, C.; Dejnirattisai, W.; Supasa, P.; Mongkolsapaya, J.; Townsend, A.; James, W. S.; Screaton, G.; van der Merwe, P. A.; Deane, C.; Isaacson, S.; Dushek, O.
10.1101/2023.09.06.556503 — immunology — Posted on 2024-04-15
2533 Excitatory neurons of the anterior cingulate cortex encode chosen actions and their outcomes rather than cognitive state
Jendryka, M. M.; Lewin, U.; Kapanaiah, S. K. T.; Dermutz, H.; Liss, B.; Pekcec, A.; Akam, T.; Grewe, B.; Kaetzel, D.
10.1101/2024.04.12.589244 — neuroscience — Posted on 2024-04-15
2535 Association of 10 VEGF Family Genes with Alzheimer's Disease Pathology at Single Cell Resolution
Wu, Y.; Libby, J. B.; Dumitrescu, L.; De Jager, P. L.; Menon, V.; Schneider, J. A.; Bennett, D. A.; Hohman, T. J.
10.1101/2024.04.12.589221 — neuroscience — Posted on 2024-04-15
2536 Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties
Shin, J. H.; Park, J.; Lim, J.; Jeong, J.; Dinesh, R. K.; Maher, S. E.; Hong, J. Y.; Wysolmerski, J.; Choi, J.; Bothwell, A. L. M.
10.1101/2024.04.12.589235 — cancer biology — Posted on 2024-04-15
2540 Sex-Specific Regulation of Stress Susceptibility by the Astrocytic Gene Htra1
Parise, E. M.; Gyles, T. M.; Godino, A.; Sial, O. K.; Browne, C. J.; Parise, L. F.; Torres-Berrio, A.; Salery, M.; Durand-de Cuttoli, R.; Rivera, M. T.; Cardona-Acosta, A. M.; Holt, L.; Markovic, T.; van der Zee, Y. Y.; Lorsch, Z. S.; Cathomas, F.; Garon, J. B.; Teague, C.; Issler, O.; Hamilton, P. J.; Bolanos-Guzman, C. A.; Russo, S. J.; Nestler, E. J.
10.1101/2024.04.12.588724 — neuroscience — Posted on 2024-04-15
2541 Confinement in fibrous environments positions and orients mitotic spindles
Sarkar, A.; Jana, A.; Agashe, A.; Wang, J.; Kapania, R.; Gov, N. S.; DeLuca, J. G.; Paul, R.; Nain, A. S.
10.1101/2024.04.12.589246 — biophysics — Posted on 2024-04-15
2544 Pangenome reconstruction in rats enhances genotype-phenotype mapping and novel variant discovery
Villani, F.; Guarracino, A.; Ward, R. R.; Green, T.; Emms, M.; Pravenec, M.; Prins, P.; Garrison, E.; Williams, R. W.; Chen, H.; Colonna, V.
10.1101/2024.01.10.575041 — genomics — Posted on 2024-04-15
2545 StratoMod: Predicting sequencing and variant calling errors with interpretable machine learning
Dwarshuis, N. J.; Tonner, P.; Olson, N. D. M.; Sedlazeck, F.; Wagner, J.; Zook, J.
10.1101/2023.01.20.524401 — genomics — Posted on 2024-04-15
2547 The INO80 ATP-dependent chromatin remodelling complex alleviates stalled Polymerase II to promote non-coding RNA transcription termination.
Luzzi, S.; Szachnowski, U.; Greener, S.; Schumacher, K.; Fulton, S.; Walton, C.; Han, K. H.; Darke, J.; Piccinno, R.; Lafon, A.; Pugh, B. F.; Devys, D.; Tora, L.; Morillon, A.; Papamichos-Chronakis, M.
10.1101/2020.03.02.973685 — molecular biology — Posted on 2024-04-15
2548 Unexpected delayed incursion of highly pathogenic avian influenza H5N1 (clade 2.3.4.4b) in the Antarctic region
Lisovski, S.; Gunther, A.; Dewar, M.; Anley, D.; Aldunate, F.; Arce, R.; Ballard, G.; Bauer, S.; Belliure, J.; Banyard, A. C.; Boulinier, T.; Bennison, A.; Braun, C.; Cary, C.; Catry, P.; Clessin, A.; Connan, M.; Correia, E.; Cox, A.; Christina, J.; Elrod, M.; Emerit, J.; Ferreiro, I.; Fowler, Z.; Gamble, A.; Granadeiro, J. P.; Hurtado, J.; Jongsomjit, D.; Kuepfer, A.; Lesage, C.; Lejeune, M.; Lescroel, A.; Li, A.; McDonald, I. R.; Menendez-Blazquez, J.; Morandini, V.; Moratorio, G.; Militao, T.; Moreno, P.; Perbolianachis, P.; Pennycook, J.; Sander, M. M.; Schmidt, A. E.; Smyth, L.; Soutullo,
10.1101/2023.10.24.563692 — microbiology — Posted on 2024-04-15
2549 Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart
Moyse, B.; Moss, J. J.; Bevan, L.; Scott, A.; Wittamer, V.; Richardson, R.
10.1101/2024.04.12.589185 — immunology — Posted on 2024-04-15
2551 Fetal protection against bovine viral diarrhea virus types 1 and 2 after vaccination of the dam with the DIVENCE vaccine
Taberner, E.; Gibert, M.; Montbrau, C.; Munoz, I.; Mallorqui, J.; Santo Tomas, H.; Prenafeta, A.; March, R.
10.1101/2024.04.12.589196 — immunology — Posted on 2024-04-15
2553 Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Haapasalo, A.; Huber, N.; Hietanen, T.; Heikkinen, S.; Shakirzyanova, A.; Hoffmann, D.; Rostalski, H.; Dhingra, A.; Rodriguez-Nieto, S.; Karkkainen, S.; Koskuvi, M.; Korhonen, E.; Hartikainen, P.; Pylkas, K.; Kruger, J.; Malm, T.; Takalo, M.; Hiltunen, M.; Koistinaho, J.; Portaankorva, A.; Solje, E.
10.1101/2024.04.12.589061 — neuroscience — Posted on 2024-04-15
2554 A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula
Vidal-Vazquez, N.; Hernandez-Nunez, I.; Carballo-Pacoret, P.; Salisbury, S.; Villamayor, P. R.; Hervas-Sotomayor, F.; Yuan, X.; Lamanna, F.; Schneider, C.; Mazan, S.; Kaessmann, H.; Adrio, F.; Robledo, D.; Barreiro-Iglesias, A.; Candal, E.
10.1101/2024.04.12.589211 — neuroscience — Posted on 2024-04-15
2555 Neuronal "parts list" and wiring diagram for a visual system
Matsliah, A.; Yu, S.-c.; Kruk, K.; Bland, D.; Burke, A.; Gager, J.; Hebditch, J.; Silverman, B.; Willie, K.; Willie, R.; Sorek, M.; Sterling, A. R.; Kind, E.; Garner, D.; Sancer, G.; Wernet, M.; Kim, S. S.; Murthy, M.; Seung, H. S.; FlyWire Consortium,
10.1101/2023.10.12.562119 — neuroscience — Posted on 2024-04-15
2557 TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate
Meng, M. Y.; Paine, L. W.; Sagnat, D.; Bello, I.; Oldroyd, S.; Javid, F.; Harper, M. T.; Hockley, J. R.; Smith, E. S. J.; Owens, R. M.; Alric, L.; Buscail, E.; Welsh, F.; Vergnolle, N.; Bulmer, D. C.
10.1101/2024.04.12.589184 — pharmacology and toxicology — Posted on 2024-04-15
2558 Traction Force Microscopy with DNA FluoroCubes
Mortazavi, A.; Jiang, J.; Laric, P.; Helmerich, D.; Seifert, R.; Sauer, M.; Sabass, B.
10.1101/2024.04.12.589182 — biophysics — Posted on 2024-04-15
2559 Compliant DNA Origami Nanoactuators as Size-Selective Nanopores
Yu, Z.; Baptist, A. V.; Reinhardt, S. C. M.; Bertosin, E.; Dekker, C.; Jungmann, R.; Heuer-Jungemann, A.; Caneva, S.
10.1101/2024.04.12.589171 — biophysics — Posted on 2024-04-15
2562 KMAP: Kmer Manifold Approximation and Projection for visualizing DNA sequences
Fu, C.; Niskanen, E. A.; Wei, G.; Yang, Z.; Sanvicente-Garcia, M.; Güell, M.; Cheng, L.
10.1101/2024.04.12.589197 — bioinformatics — Posted on 2024-04-15
2564 Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification
Bobbili, M. R.; Gorgens, A.; Yan, Y.; Vogt, S.; Gupta, D.; Corso, G.; Barbaria, S.; Patrioli, C.; Weilner, S.; Pultar, M.; Jacak, J.; Hackl, M.; Schosserer, M.; Grillari, R.; Kjems, J.; EL Andaloussi, S.; Grillari, J.
10.1101/2024.04.12.589209 — bioengineering — Posted on 2024-04-15
2565 In vivo evaluation of thermally drawn biodegradable optical fibers as brain neural interfaces
Abdollahian, P.; Sui, K.; Li, G.; Wang, J.; Zhang, C.; Wang, Y.; Berg, R. W.; Meneghetti, M.; Markos, C.
10.1101/2024.04.08.588517 — bioengineering — Posted on 2024-04-15
2566 Plant metabolites modulate animal social networks and lifespan
SINGH, P.; Brueggemann, L.; Janz, S.; Saidi, Y.; Baruah, G.; Müller, C.
10.1101/2023.12.20.572488 — animal behavior and cognition — Posted on 2024-04-15
2567 Precision and Accuracy of Single-Cell/Nuclei RNA Sequencing Data
Dai, R.; Zhang, M.; Chu, T.; Kopp, R.; Zhang, C.; Liu, K.; Wang, Y.; Wang, X.; Chen, C.; Liu, C.
10.1101/2024.04.12.589216 — genomics — Posted on 2024-04-15
2569 Exploring functional conservation in silico: a new machine learning approach to RNA-editing
Zawisza-Alvarez, M.; Penuela-Melero, J.; Vegas, E.; Reverter, F.; Garcia-Fernandez, J.; Herrera-Ubeda, C.
10.1101/2023.11.21.568001 — genetics — Posted on 2024-04-15
2572 Discordance between phylogenomic datasets in aphids: who is telling the truth?
Jousselin, E.; Coeur d'acier, A.; Clamens, A.-l.; Galan, M.; Cruaud, C.; Barbe, V.; Manzano-Marin, A.
10.1101/2024.04.12.589189 — evolutionary biology — Posted on 2024-04-15
2573 The neonicotinoid acetamiprid is highly toxic to wild non-target insects
Sedlmeier, J. E.; Petschenka, G.; Bruehl, C. A.; Grass, I.; Gerhard, D.; Walker, F.; Hoeglinger, B.; Bendalam, P.; Piepho, H.-P.
10.1101/2024.04.11.589033 — ecology — Posted on 2024-04-15
2576 psudo: Exploring Multi-Channel Biomedical Image Data with Spatially and Perceptually Optimized Pseudocoloring
Warchol, S.; Troidl, J.; Muhlich, J. L.; Krueger, R.; Hoffer, J.; Lin, T.; Beyer, J.; Glassman, E.; Sorger, P. K.; Pfister, H.
10.1101/2024.04.11.589087 — cell biology — Posted on 2024-04-15
2580 Frictiotaxis underlies adhesion-independent durotaxis
Shellard, A.; Weissenbruch, K. W.; Hampshire, P.; Stillman, N.; Dix, C.; Thorogate, R.; Imbert, A.; Charras, G.; Alert, R.; Mayor, R.
10.1101/2023.06.01.543217 — cell biology — Posted on 2024-04-15
2584 Chemogenetic stimulation of phrenic motor output and diaphragm activity
Benevides, E. S.; Thakre, P. P.; Rana, S.; Sunshine, M. D.; Jensen, V. N.; Oweiss, K.; Fuller, D.
10.1101/2024.04.12.589188 — neuroscience — Posted on 2024-04-15
2585 What underlies exceptional memory function in older age? No evidence for aging-specific relationships to hippocampal atrophy and retrieval activity
Fjell, A.; Sneve, M. H.; Amlien, I. K.; Grydeland, H.; Mowinckel, A. M.; Vidal-Pineiro, D.; Sorensen, O.; Walhovd, K. B.
10.1101/2024.04.12.589183 — neuroscience — Posted on 2024-04-15
2586 Utilising activity patterns of a complex biophysical network model to optimise intra-striatal deep brain stimulation
Spiliotis, K.; Appali, R.; Gomes, A. F.; Payonk, J. P.; Adrian, S.; van Rienen, U.; Starke, J.; Koehling, R.
10.1101/2024.04.12.589107 — neuroscience — Posted on 2024-04-15
2587 WHIRLY1 regulates aliphatic glucosinolate biosynthesis in early seedling development of Arabidopsis
Nguyen, L. T.; Moutesidi, P.; Glasneck, A.; Khosravi, S.; Abel, S.; Hensel, G.; Krupinska, K.; Humbeck, K.
10.1101/2024.04.12.589156 — plant biology — Posted on 2024-04-15
2591 BunDLe-Net: Neuronal Manifold Learning Meets Behaviour
Kumar, A.; Gilra, A.; Gonzalez-Soto, M.; Meunier, A.; Grosse-Wentrup, M.
10.1101/2023.08.08.551978 — neuroscience — Posted on 2024-04-15
2593 Individual variability in sensorimotor learning reflects trait-like neurobehavioral subject factors
Areshenkoff, C. N.; de Brouwer, A. J.; Standage, D.; Nashed, J. Y.; Gale, D. J.; Flanagan, J. R.; Gallivan, J.
10.1101/2024.04.11.589135 — neuroscience — Posted on 2024-04-15
2594 Distinct mechanisms of visual and sound adaptation in the cat visual cortex
Belkacemi, Y. Y.; Hospital, S.; Chanauria, N.; Flouty, O.; Molotchnikoff, S.; Bharmauria, V.
10.1101/2024.04.11.589131 — neuroscience — Posted on 2024-04-15
2596 MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability
Jasani, N.; Xu, X.; Posorske, B.; Kim, Y.; Vera, O.; Tsai, K. Y.; DeNicola, G. M.; Karreth, F. A.
10.1101/2024.04.11.589139 — cancer biology — Posted on 2024-04-15
2601 Comparing the effect of imputation reference panel composition in four distinct Latin American cohorts
French, J. N.; Borda Pua, V. O.; Laboulaye, R.; Peixoto Leal, T.; Cornejo-Olivas, M.; Lima-Costa, M. F.; Horta, B. L.; Barreto, M. L.; Tarazona-Santos, E.; Mata, I.; O'Connor, T. D.
10.1101/2024.04.11.589057 — genomics — Posted on 2024-04-15
2602 Trace DNA from kill sites identifies predating tigers
Chhattani, H.; Harihar, A.; Dean, R.; Yadav, A.; Patel, K.; Rana, D.; Pandit, A.; Shukla, S. K.; Rahim, V.; Ramakrishnan, U.
10.1101/2024.04.11.589017 — genetics — Posted on 2024-04-15
2604 Effects of environmental change on population growth: monitoring time-varying carrying capacity in free-ranging spotted hyenas
Bailey, L. D.; Hoener, O. P.; Davidian, E.; Dheer, A.; Radchuk, V.; Walter, L. F.; White, E. W.; Courtiol, A.
10.1101/2024.04.11.589105 — ecology — Posted on 2024-04-15
2605 Reassessing global historical R0 estimates of canine rabies
Li, M.; Roswell, M.; Hampson, K.; Bolker, B.; Dushoff, J.
10.1101/2024.04.11.589097 — ecology — Posted on 2024-04-15
2606 Proteomic profile analysis of plasma and aqueous humor from glaucoma and non-glaucomatous patients
Pessuti, C. L.; Huang, C.-L.; Banks, A.; Vo, N.; Jennings, L.; Loureiro, J.; Ribeiro, K.; Costa, D. F.; Nascimento, H.; Muccioli, C.; Tavares, I. M.; Commodaro, A.; Belfort, R.; Wilson, C.; Chen, A.; Prasanna, G.; Raghunathan, V.
10.1101/2024.04.11.588885 — cell biology — Posted on 2024-04-15
2607 Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease
Mendiratta, M.; Mendiratta, M.; Ganguly, S. K.; Rai, S.; Gupta, R.; Kumar, L.; Bakhshi, S.; Dadhwal, V.; Pushpam, D.; Malik, P. S.; Pramanik, R.; Aggarwal, M.; Gupta, A. K.; Dhawan, R.; Seth, T.; Mahapatra, M.; Nayak, B.; Singh, T. D.; Singla, S. K.; Singh, M.; Prasad, C. P.; Prakash, H.; Mohanty, S.; Sahoo, R. K.
10.1101/2024.04.11.588248 — immunology — Posted on 2024-04-15
2608 A protective role for B-1 cells and oxidation-specific epitope IgM in lung fibrosis
Sturek, J. M.; Hannan, R. T.; Upadhye, A.; Otoupalova, E.; Faron, E. T.; Atya, A. A. E.; Thomas, C.; Johnson, V.; Miller, A.; Garmey, J. C.; Burdick, M. D.; Barker, T. H.; Kadl, A.; Shim, Y. M.; McNamara, C. A.
10.1101/2024.04.11.589137 — immunology — Posted on 2024-04-15
2609 Network Spreading and Local Biological Vulnerability in Amyotrophic Lateral Sclerosis
Farahani, A.; Hansen, J.; Bazinet, V.; Shafiei, G.; Collins, D. L.; Dadar, M.; Karla, S.; Dagher, A.; Misic, B.
10.1101/2024.04.11.588760 — neuroscience — Posted on 2024-04-15
2613 Atypical Pupil-Linked Arousal Induced by Low-Risk Probabilistic Choices, and Intolerance of Uncertainty in Adults with ASD
Pultsina, K.; Stroganova, T.; Kozunova, G.; Miasnikova, A.; Prokofyev, A.; Rytikova, A.; Chernyshev, B.
10.1101/2024.04.11.589067 — neuroscience — Posted on 2024-04-15
2616 Classifying native versus foreign speech perception from EEG using linguistic speech features
Puffay, C.; Vanthornhout, J.; Gillis, M.; De Clercq, P.; Accou, B.; Van hamme, H.; Francart, T.
10.1101/2024.04.11.589055 — neuroscience — Posted on 2024-04-15
2619 Regulation of lung cancer initiation and progression by the stem cell determinant Musashi
Barber, A. G.; Quintero, C. M.; Hamilton, M.; Rajbhandari, N.; Sasik, R.; Zhang, Y.; Kim, C.; Husain, H.; Sun, X.; Reya, T.
10.1101/2024.04.11.589053 — cancer biology — Posted on 2024-04-15
2620 DeepRBP: A novel deep neural network for inferring splicing regulation
Sancho Zamora, J.; Ferrer-Bonsoms, J. A.; Olaverri-Mendizabal, D.; Carazo, F.; Valcarcel, L. V.; Ochoa, I.
10.1101/2024.04.11.589004 — bioinformatics — Posted on 2024-04-15
2621 Mosaic display of stable hemagglutinin monomers induces broad immune responses
Kim, H.; Min, S. C.; Lee, D. B.; Jeong, J. H.; Kim, E. J.; Maeng, J. Y.; Seok, J. H.; Lee, J.-H.; Jang, Y.; Jang, U. S.; Ysenbaert, T.; Catani, J. P. P.; Lee, J.; Lee, Y.; Kim, Y. K.; Lee, G.; Mun, J. Y.; Jun, H. S.; Baek, Y. H.; Saelens, X.; Lee, J.; Chung, M. S.; Song, M.-S.; Kim, K. H.
10.1101/2024.04.10.588945 — bioengineering — Posted on 2024-04-15
2624 Toll-like receptor 3 orchestrates a conserved mechanism of heart regeneration
Fiegl, M.; Roehrs, B. T.; Hau, D.; Mair, S.; Niederwanger, P.; Regele, D.; Merotto, L.; Töchterle, S.; Engler, C.; Graber, M.; Kirchmair, E.; Niedrist, V.; Muller, L.; Pölzl, L.; Hirsch, J.; Nägele, F.; Happacher, I.; Oberegger, S.; Bonaros, N.; Grimm, M.; Tancevski, I.; Finotello, F.; Meyer, D.; Holfeld, J.; Gollmann-Tepekoeylue, C.
10.1101/2024.04.12.589327 — molecular biology — Posted on 2024-04-15
2625 Carbon Dioxide Controls Fungal Fitness and Skin Tropism of Candida auris
Trinh, P.-C.; Penninger, P.; Seiser, S.; Khunweeraphong, N.; Moser, D.; Bitencourt, T.; Arzani, H.; Chen, W.; Zenz, L.-M.; Knarr, A.; Cerbu, D.; Jenull, S.; Muller, C.; Lackner, M.; Ianiri, G.; Chowdhary, A.; Hartl, M.; Elbe-Burger, A.; Kuchler, K.
10.1101/2024.04.12.589292 — microbiology — Posted on 2024-04-15
2626 Cross-reactivity of rPvs48/45, a recombinant Plasmodium vivax protein, with sera from Plasmodium falciparum endemic areas of Africa
Arevalo-Herrera, M.; Balam, S.; Miura, K.; Ayadi, I.; Konate, D.; Incandela, N. C.; Agnolon, V.; Guindo, M. A.; Diakite, S. A. S.; Olugbile, S.; Nebie, I.; Herrera, S. M.; Long, C.; Kajava, A. V.; Diakite, M.; Corradin, G.; Herrera, S.
10.1101/2024.04.10.588966 — immunology — Posted on 2024-04-15
2627 Extracellular vesicles from preeclampsia disrupt the blood-brain barrier via reduced claudin-5: potential role of vascular endothelial growth factor
Sandoval, H.; Ibanez, B.; Contreras, M.; Troncoso, F.; Castro, F. O.; Caamano, D.; Mendez, L.; Escudero-Guevara, E. A.; Mistry, H. D.; Kurlak, L. O.; Vatish, M.; Acurio, J.; Escudero, C.
10.1101/2024.04.10.588960 — physiology — Posted on 2024-04-15
2628 Genomic epidemiology of Plasmodium knowlesi reveals putative genetic drivers of adaptation in Malaysia.
Westaway, J.; Diez Benavente, E.; Auburn, S.; Kucharski, M.; Aranciaga, N.; Nayak, S.; William, T.; Rajahram, G. S.; Piera, K. A.; Braima, K.; Tan, A. F.; Alaza, D.; Barber, B. E.; Drakeley, C.; Amato, R.; Sutanto, E.; Trimarsanto, H.; Anstey, N. M.; Bozdech, Z.; Field, M.; Grigg, M. J.
10.1101/2024.04.10.588982 — genomics — Posted on 2024-04-15
2629 The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: implications for deep space missions, female crews, and potential antioxidant countermeasures
Yun, S.; Kiffer, F. C.; Guzman, C. S.; Soler, I.; Bancroft, G. L.; Haas, H. A.; Shi, R.; Patel, R. A.; Lara-Jimenez, J. A.; Kumar, P. L.; Tran, F. H.; Ahn, K. J.; Rong, Y.; Luitel, K.; Shay, J. W.; Eisch, A. J.
10.1101/2024.04.12.588768 — neuroscience — Posted on 2024-04-15
2630 Glial state changes and neuroinflammatory RIPK1 signaling are a key feature of ALS pathogenesis
Zelic, M.; Blazier, A.; Pontarelli, F.; LaMorte, M.; Huang, J.; Tasdemir-Yilmaz, O. E.; Ren, Y.; Ryan, S. K.; Krishnaswami, P.; Levit, M.; Sood, D.; Chen, Y.; Gans, J.; Tang, X.; Hsiao-Nakamoto, J.; Huang, F.; Zhang, B.; Gaglia, G.; Ofengeim, D.; Hammond, T. R.
10.1101/2024.04.12.589201 — neuroscience — Posted on 2024-04-15
2631 Vimentin regulates mitochondrial ROS production and inflammatory responses of neutrophils
Huynh, T. N.; Toperzer, J.; Scherer, A.; Gumina, A.; Brunetti, T.; Mansour, M. K.; Markovitz, D. M.; Russo, B. C.
10.1101/2024.04.11.589146 — immunology — Posted on 2024-04-15
2635 Mutations in the IgG B cell receptor associated with class-switched B cell lymphomas
Wasim, L.; Chu, S. W. T.; Sale, B.; Pickard, L.; Leonard, S.; Zhang, L.; Tolarova, H.; Tean, Z. S.; Engels, N.; Calado, D. P.; Tarte, K.; Okosun, J.; Forconi, F.; Tolar, P.
10.1101/2024.04.12.585865 — immunology — Posted on 2024-04-15
2636 Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration
Nascimento, F.; Ozyurt, M. G.; Halablab, K.; Bhumbra, G. S.; Caron, G.; Baczyk, M.; Zytnicki, D.; Manuel, M.; Roselli, F.; Brownstone, R. M.; Beato, M.
10.1101/2024.04.10.588918 — neuroscience — Posted on 2024-04-14
2637 Audio-visual concert performances synchronize an audience's heart rates
Czepiel, A. M.; Fink, L. K.; Scharinger, M.; Seibert, C.; Wald-Fuhrmann, M.; Kotz, S. A.
10.1101/2024.04.10.588486 — neuroscience — Posted on 2024-04-14
2638 Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally
Zhao, R.; Ren, B.; Xiao, Y.; Tian, J.; Zou, Y.; Wei, J.; Qi, Y.; Hu, A.; Xie, X.; Huang, Z. J.; Shu, Y.; He, M.; Lu, J.; Tai, Y.
10.1101/2024.04.11.589005 — neuroscience — Posted on 2024-04-15
2642 Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor
Suno-Ikeda, C.; Nishikawa, R.; Suzuki, R.; Iwata, S.; Takai, T.; Ogura, T.; Hirose, M.; Inoue, A.; Asai, E.; Kise, R.; Sugita, Y.; Kato, T.; Nagase, H.; Saito, T.; Katayama, K.; Inoue, A.; Kandori, H.; Kobayashi, T.; Suno, R.
10.1101/2024.04.11.588819 — biophysics — Posted on 2024-04-15
2643 Modeling cardiac microcirculation for the simulation of coronary flow and 3D myocardial perfusion
Montino Pelagi, G.; Regazzoni, F.; Huyghe, J. M.; Baggiano, A.; Ali, M.; Bertoluzza, S.; Valbusa, G.; Pontone, G.; Vergara, C.
10.1101/2024.04.11.588994 — bioengineering — Posted on 2024-04-15
2645 Mitochondrial complex I deficiency stratifies idiopathic Parkinson's disease
Flones, I.; Toker, L.; Sandnes, D. A.; Castelli, M.; Mostafavi, S.; Lura, N.; Shadad, O.; Fernandez-Vizarra, E.; Painous, C.; Perez-Soriano, A.; Compta, Y.; Molina-Porcel, L.; Alves, G.; Tysnes, O.-B.; Dolle, C.; Nido, G. S.; Tzoulis, C.
10.1101/2023.09.22.558615 — neuroscience — Posted on 2024-04-15
2646 Alteration of nociceptive Schwann cells in a mouse model of peripheral neuropathy in prediabetic condition
Rastoldo, G.; Jaafar, A. K.; Paulo-Ramos, A.; Thouvenot, K.; Planesse, C.; Bringart, M.; Gonthier, M.-P.; Lambert, G.; Bourane, S.
10.1101/2024.03.12.584541 — neuroscience — Posted on 2024-04-15
2647 Actin polymerization counteracts prewetting of N-WASP on supported lipid bilayers
Wiegand, T.; Liu, J.; Fritsch, A. W.; Vogeley, L.; Luvalle-Burke, I.; Geisler, J.; Hyman, A. A.; Grill, S. W.
10.1101/2024.04.14.589463 — biophysics — Posted on 2024-04-15
2648 Same data, different results? Evaluating machine learning approaches for individual identification in animal vocalisations
Wierucka, K.; Murphy, D.; Watson, S. K.; Falk, N.; Fichtel, C.; Leon, J.; Leu, S. T.; Kappeler, P. M.; Briefer, E. F.; Manser, M. B.; Phaniraj, N.; Scheumann, M.; Burkart, J. M.
10.1101/2024.04.14.589403 — animal behavior and cognition — Posted on 2024-04-14
2655 Supervised contrastive learning enhances MHC-II peptide binding affinity prediction
Shen, L.-C.; Yan, L.; Liu, Z.; Zhang, Y.; Wang, Z.; Guo, Y.; Rossjohn, J.; Song, J.; Yu, D.-J.
10.1101/2023.12.21.572942 — bioinformatics — Posted on 2024-04-14
2656 Characterizing the monomer-dimer equilibrium of UbcH8/Ube2L6: A combined SAXS and NMR study
Kahraman, K.; Robson, S. A.; Gocenler, O.; Yenici, C. M.; Tozkoparan, C. D.; Klein, J. M.; Dötsch, V.; Elgin, E. S.; Haas, A. L.; Ziarek, J. J.; Dag, C.
10.1101/2023.04.13.536743 — biochemistry — Posted on 2024-04-14
2658 p53 secures the normal behavior of H3.1 histone in the nucleus by regulating nuclear phosphatidic acid and EZH2 during the G1/S phase
Oikawa, T.; Hasegawa, J.; Handa, H.; Ohnishi, N.; Onodera, Y.; Hashimoto, A.; Sasaki, J.; Sasaki, T.; Ueda, K.; Sabe, H.
10.1101/2023.06.27.545208 — cell biology — Posted on 2024-04-14
2660 Properties of the Ureaplasma parvum SMC protein related to its interaction with DNA
Rumyantseva, N. A.; Shutov, V. M.; Belenkaya, D. G.; Alekseev, A. A.; Morozova, N. E.; Vedyaykin, A. D.
10.1101/2024.04.14.589448 — molecular biology — Posted on 2024-04-14
2661 HOP/STIP1 is required for KSHV lytic replication.
Kirigin, E.; Matandirotya, L.; Ruck, J.-L.; Weaver, F.; Jackson, Z.; Chakraborty, A.; Veale, C. G. L.; Whitehouse, A.; Edkins, A. L.
10.1101/2024.04.13.589363 — microbiology — Posted on 2024-04-14
2662 Corticospinal and corticoreticulospinal projections benefit motor behaviors in chronic stroke
Taga, M.; Hong, Y. N. G.; Charalambous, C. C.; Raju, S.; Hayes, L.; Lin, J.; Zhang, Y.; Shao, Y.; Houston, M.; Zhang, Y.; Mazzoni, P.; Roh, J.; Schambra, H.
10.1101/2024.04.04.588112 — neuroscience — Posted on 2024-04-14
2665 Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes.
Qadir, M. M. F.; Elgamal, R. M.; Song, K.; Kudtarkar, P.; Sakamuri, S. S. V. P.; Katakam, P. V.; El-Dahr, S.; Kolls, J. K.; Gaulton, K. J.; Mauvais-Jarvis, F.
10.1101/2024.04.11.589096 — genomics — Posted on 2024-04-14
2666 CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility
Wu, B.; Long, C.; Yang, Y.; Zhang, Z.; Ma, S.; Ma, Y.; Wei, H.; Li, J.; Jiang, H.; Li, W.; Liu, C.
10.1101/2024.04.12.589289 — developmental biology — Posted on 2024-04-14
2667 TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling
Engelmann, J.; Zarrer, J.; Schmerder, M. J.; Mess, C.; Ragipoglu, D.; Riecken, K.; Burstyn-Cohen, T.; Alberto, E.; Ghosh, S.; Rothlin, C. V.; Pantel, K.; Bokemeyer, C.; Hesse, E.; Taipaleenmaeki, H.; Loges, S.; Ben-Batalla, I.
10.1101/2024.04.12.589232 — cell biology — Posted on 2024-04-14
2668 In-depth study of MPV17: a molecular travel unveiling a mitochondrial calcium regulation function
Meurant, S.; Amato, I.; Mauclet, L.; Dieu, M.; Chevrollier, A.; Ledoux, B.; Caruso, M.; Lenaers, G.; Arnould, T.; Renard, P.
10.1101/2024.04.12.589178 — cell biology — Posted on 2024-04-14
2670 KIF2C-induced nuclear condensation concentrates PLK1 and phosphorylated BRCA2 at the kinetochore microtubules in mitosis
Skobelkina, A.; Julien, M.; Jeannin, S.; Miron, S.; Egger, T.; Chaaban, R.; Bouvignies, G.; Ghouil, R.; Friel, C.; BUSSO, D.; Theillet, F.-X.; Le Bars, R.; Carreira, A.; Constantinou, A.; Basbous, J.; ZINN-JUSTIN, S.
10.1101/2024.04.13.589357 — cell biology — Posted on 2024-04-14
2671 ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression
Elowe, S.; Prifti, D. K.; Calvo, E.; Lauzier, A.; Garand, C.; Devillers, R.; Roy, S.; dos Santos, A.; Descombes, L.; Bordeleau, F.
10.1101/2024.04.14.589449 — cell biology — Posted on 2024-04-14
2676 Uncovering Porphyrin Accumulation in the Tumor Microenvironment
Jiang, R. H. Y.; Adapa, S. R.; Sami, A.; Meshram, P.; Ferreria, G. C.
10.1101/2024.04.11.589133 — cancer biology — Posted on 2024-04-14
2679 Rapid and Sensitive Protein Complex Alignment with Foldseek-Multimer
Kim, W.; Mirdita, M.; Karin, E. L.; Gilchrist, C. L. M.; Schweke, H.; Soeding, J.; Levy, E.; Steinegger, M.
10.1101/2024.04.14.589414 — bioinformatics — Posted on 2024-04-14
2683 Epigenetic Remodeling in Human Coronary Artery Smooth Muscle Cell Phenotypic Switching
Chakraborty, R.; Schulz, V. P.; Lezon-Geyda, K.; Dave, J. M.; Martin, K. A.; Gallagher, P. G.
10.1101/2024.04.11.589030 — genomics — Posted on 2024-04-14
2684 Poseidon - A framework for archaeogenetic human genotype data management
Schmid, C.; Ghalichi, A.; Lamnidis, T. C.; Athanayaka Mudiyanselage, D. B.; Haak, W.; Schiffels, S.
10.1101/2024.04.12.589180 — genetics — Posted on 2024-04-14
2686 Phaeocystis blooms caused carbon drawdown during the Antarctic Cold Reversal from sedimentary ancient DNA
Weiss, J. F.; Herzschuh, U.; Mueller, J.; Liang, J.; Vorrath, M.-E.; Perfumo, A.; Stoof-Leichsenring, K. R.
10.1101/2024.04.11.589015 — ecology — Posted on 2024-04-14
2687 Lung megakaryocytes are long-lived, arise from Flt3-negative bone marrow cells, and contribute to platelet recovery in thrombocytopenia
Livada, A.; McGrath, K. E.; Malloy, M.; Li, C.; Ture, S. K.; Kingsley, P. D.; Koniski, A. D.; Vit, L. A.; Nolan, K. E.; Mickelsen, D.; Monette, G.; Maurya, P.; Palis, J.; Morrell, C. N.
10.1101/2024.04.11.589077 — cell biology — Posted on 2024-04-14
2692 Upper respiratory microbial communities of healthy populations are shaped by niche and age
Zelasko, S.; Swaney, M. H.; Sandstrom, S.; Davenport, T. C.; Seroogy, C. M.; Kalan, L. R.; Currie, C. R.
10.1101/2024.04.14.589416 — microbiology — Posted on 2024-04-14
2694 Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification
Haag, S. M.; Xie, S.; Eidenschenk, C.; Fortin, J.-P.; Callow, M.; Costa, M.; Lun, A.; Cox, C.; Wu, S. Z.; Pradhan, R. N.; Lock, J.; Kuhn, J. A.; Holokai, L.; Thai, M.; Freund, E.; Nissenbaum, A.; Keir, M.; Bohlen, C. J.; Martin, S.; Geiger-Schuller, K.; Hejase, H. A.; Yaspan, B. L.; Melo Carlos, S.; Turley, S. J.; Murthy, A.
10.1101/2024.04.12.589122 — immunology — Posted on 2024-04-14
2696 PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner
Iannotta, L.; Fasiczka, R.; Favetta, G.; Zhao, Y.; Giusto, E.; Dall'Ara, E.; Wei, J.; Ho, F.; Ciriani, C.; Cogo, S.; Tessari, I.; Iaccarino, C.; Liberelle, M.; Bubacco, L.; Taymans, J.-M.; Manzoni, C.; Kortholt, A.; Civiero, L.; Hilfiker, S.; Lu, M.; Greggio, E.
10.1101/2024.04.11.589075 — neuroscience — Posted on 2024-04-14
2698 Tunable Universal OR-gated CAR T cells for AML
Siddiqui, M. Y.; Chen, J.; Loffredo, M.; Lee, S.; Deng, H.; Li, Y.; Leemans, N.; Lu, T.; Garrison, B. S.; Ayala, M. G.; Frankel, N. W.; Wong, W. W.
10.1101/2024.04.13.589307 — synthetic biology — Posted on 2024-04-14
2701 A registration strategy to characterize DTI-observed changes in skeletal muscle architecture due to passive shortening
Hooijmans, M. T.; Lockard, C. A.; Zhou, X.; Coolbaugh, C.; Guzman, R. P.; Kersh, M. E.; Damon, B. M.
10.1101/2024.04.11.589123 — physiology — Posted on 2024-04-14
2702 Water Diffusion in the Live Human Brain is Gaussian at the Mesoscale
Magdoom, K. N.; Avram, A. V.; Witzel, T.; Huang, S. Y.; Basser, P. J.
10.1101/2024.04.10.588939 — biophysics — Posted on 2024-04-14
2703 Circadian rhythms tied to changes in brain morphology in a densely-sampled male
Murata, E. M.; Pritschet, L.; Grotzinger, H.; Taylor, C. M.; Jacobs, E. G.
10.1101/2024.04.10.588906 — neuroscience — Posted on 2024-04-14
2707 Worldwide soundscape ecology patterns across realms
Darras, K. F.; Rountree, R.; Van Wilgenburg, S.; Dong, L.; Gasc, A.; Chen, Y.; Lin, T.-H.; Diaz, P. M.; Wu, S.-H.; Salton, M.; Marley, S.; Cord, A. F.; Aparecido Do Nascimento, L.; Astaras, C.; Barbaro, L.; Bellisario, K.; Ben David, A.; Berger-Tal, O.; Bhalla, I.; Bolgan, M.; Bradfer-Lawrence, T.; Briers, R. A.; Budka, M.; Cerezo-Araujo, M.; Cerwen, G.; Desjonqueres, C.; Diniz, P.; Duarte, A.; Enari, H.; Enari, H. S.; Freitas, B.; Friedman, N.; Froidevaux, J.; Gogoleva, S.; Goodale, E.; Greenhalgh, J.; Hagge, J.; Jacot, A.; Jahn, O.; Kepfer Rojas, S.; Lloyd, K. J.; Mammides, C.; Marcacci, G.;
10.1101/2024.04.10.588860 — ecology — Posted on 2024-04-14
2709 Neurovascular coupling and briefCO2 interrogate distinct vascular regulations
Tournissac, M.; Chaigneau, E.; Pfister, S.; Aydin, A.-K.; Goulam Houssen, Y.; O'Herron, P.; Filosa, J.; Collot, M.; Joutel, A.; Charpak, S.
10.1101/2024.04.10.588509 — neuroscience — Posted on 2024-04-14
2711 Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown
Lawrence, J. H.; Patel, A.; King, M. W.; Nadarajah, C. J.; Daneman, R.; Musiek, E. S.
10.1101/2024.04.10.588924 — neuroscience — Posted on 2024-04-14
2713 Pleasurable music activates cerebral μ-opioid receptors: A combined PET-fMRI study
Putkinen, V. J.; Seppala, K.; Harju, H.; Hirvonen, J.; Karlsson, H.; Nummenmaa, L.
10.1101/2024.04.10.588805 — neuroscience — Posted on 2024-04-14
2714 Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque
Schmidt, J.; Wilson, R.; Davenport, B.; Hacker, T.; Fitz, C.; Simmons, H. A.; Schotzko, M. L.; Golos, T.; Jones, H.
10.1101/2024.04.10.588902 — physiology — Posted on 2024-04-14
2715 A quantitative tumor-wide analysis of morphological heterogeneity of colorectal adenocarcinoma
Dragomir, M. P.; Popovici, V.; Schallenberg, S.; Carnogurska, M.; Horst, D.; Nenutil, R.; Bosman, F.; Budinska, E.
10.1101/2024.04.10.588907 — cancer biology — Posted on 2024-04-14
2717 Cross-platform proteomics signatures of extreme old age
Reed, E. R.; Chandler, K. B.; Lopez, P.; Costello, C. E.; Anderson, S. L.; Perls, T. T.; Li, M.; Bae, H.; Soerensen, M.; Monti, S.; Sebastiani, P.
10.1101/2024.04.10.588876 — bioinformatics — Posted on 2024-04-14
2718 PIMMS-Dash: Accessible analysis, interrogation, and visualisation of high-throughput transposon insertion sequencing (TIS) data
Blanchard, A. M.; Taylor, A.; Warry, A.; Shephard, F.; Curwen, A.; Leigh, J. A.; Emes, R. D.; Egan, S. A.
10.1101/2024.04.10.588854 — bioinformatics — Posted on 2024-04-14
2719 Loss of TRIM21 drives UVB-induced systemic inflammation by regulating DNA-sensing pathways
Tumurkhuu, G.; Moore, R.; Perri, G.; De Los Santos, G.; Laguna, D. E.; Gibb, D.; Carriere, J.; Stehlik, C.; Jefferies, C.
10.1101/2024.04.10.588897 — immunology — Posted on 2024-04-14
2726 Isogenic hiPSC models of Turner syndrome development reveal shared roles of inactive X and Y in the human cranial neural crest network
Ahern, D. T.; Bansal, P.; Faustino, I. V.; Glatt-Deeley, H. R.; Massey, R. E.; Kondaveeti, Y.; Banda, E. C.; Pinter, S. F.
10.1101/2023.03.08.531747 — developmental biology — Posted on 2024-04-14
2728 Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment
Prowse, E. N. P.; Turkalj, B. A.; Sebastien, M.; Beaudet, D.; McBride, H. M.; Brouhard, G. J.; Pouladi, M. A.; Hendricks, A. G.
10.1101/2024.04.12.589210 — cell biology — Posted on 2024-04-14
2729 Impact of redox fluctuations on the spatial distribution of the microbial community in a forest soil: A lysimeter experiment
Wang, S.; Miele, F.; Benettin, P.; Asadollahi, M.; Pasqualini, J.; Frutschi, M.; Rossi, P.; Jacquemin, N.; Rinaldo, A.; Bernier-Latmani, R.
10.1101/2024.04.11.588997 — microbiology — Posted on 2024-04-14
2730 Study design features that improve effect sizes in cross-sectional and longitudinal brain-wide association studies
Kang, K.; Seidlitz, J.; Bethlehem, R. A. I.; Xiong, J.; Jones, M. T.; Mehta, K. P.; Keller, A.; Tao, R.; Randolph, A.; Larsen, B.; Tervo-Clemmens, B.; Feczko, E. J.; Miranda Dominguez, O.; Nelson, S.; Lifespan Brain Chart Consortium, ; 3R-BRAIN, ; AIBL, ; Alzheimer's Disease Neuroimaging Initiative, ; Alzheimer's Disease Repository Without Borders Investigators, ; CALM Team, ; CCNP, ; COBRE, ; cVEDA, ; Harvard Aging Brain Study, ; IMAGEN, ; POND, ; The PREVENT-AD Research Group, ; Schildcrout, J.; Fair, D.; Satterthwaite, T. D.; Alexander-Bloch, A.; Vandekar, S.
10.1101/2023.05.29.542742 — neuroscience — Posted on 2024-04-14
2732 NSCLC patients with oligo-metastatic brain disease show an altered CD4 T-cells immune profile
Alsousli, M.; Maire, C.; Piffko, A.; Matschke, J.; Glau, L.; Reetz, M.; Schneegans, S.; Emurlai, G.; Asey, B.; Ruenger, A.; Peine, S.; Kropidlowski, J.; Gempt, J.; Glatzel, M.; Westphal, M.; Tolosa, E.; Lamszus, K.; Pantel, K.; Joosse, S. A.; Mohme, M.; Wikman, H.
10.1101/2024.04.10.588829 — cancer biology — Posted on 2024-04-14
2733 Marine protected areas promote resilience of kelp forests to marine heatwaves by preserving trophic cascades
Kumagai, J. A.; Goodman, M. C.; Villasenor-Derbez, J. C.; Schoeman, D. S.; Cavanaugh, K. C.; Bell, T. W.; Micheli, F.; De Leo, G. A.; Arafeh-Dalmau, N.
10.1101/2024.04.10.588833 — ecology — Posted on 2024-04-14
2739 A Stapled Peptide Inhibitor of METTL3-METTL14 for Cancer Therapy
Li, Z.; Feng, Y.; Han, H.; Jiang, X.; Chen, W.; Ma, X.; Mei, Y.; Yan, X.; Yin, P.; Yuan, D.; Zhang, D.; Shi, J.
10.1101/2023.09.04.556216 — biochemistry — Posted on 2024-04-14
2744 Shaping human gut community assembly and butyrate production by controlling the arginine dihydrolase pathway
Liu, Y.; Cheng, Y.-Y.; Thompson, J.; Zhou, Z.; Vivas, E. I.; Warren, M. F.; Rey, F. E.; Anantharaman, K.; Venturelli, O. S.
10.1101/2023.01.10.523442 — systems biology — Posted on 2024-04-14
2745 Decoding Proteoforms with Single Acid Resolution Using a Sub-nanometer Diameter Pore
Paul, A.; Rayabharam, A.; Murkate, P.; Almonte, L.; Rigo, E.; Dong, Z.; Kumar, A.; Joseph, J.; Aluru, N. R.; Timp, G.
10.1101/2022.12.22.521660 — biophysics — Posted on 2024-04-14
2748 Dysregulation in Spatiotemporal Expression of HMX1 Coordinated by Multifaceted Enhancers Drives an Auricular Disorder
Xu, X.; Chen, Q.; Huang, Q.; Cox, T. C.; Zhu, H.; Hu, J.; Han, X.; Meng, Z.; Wang, B.; Liao, Z.; Xu, W.; Xiao, B.; Lang, R.; Liu, J.; Li, Q.; Zhang, Q.; Antonarakis, S. E.; Zhang, J.; Fan, X.; Liu, H.; Zhang, Y.-B.
10.1101/2024.04.01.587639 — developmental biology — Posted on 2024-04-14
2750 The landscape of regional missense mutational intolerance quantified from 125,748 exomes
Chao, K. R.; Wang, L.; Panchal, R.; Liao, C.; Abderrazzaq, H.; Ye, R.; Schultz, P.; Compitello, J.; Grant, R. H.; Kosmicki, J. A.; Weisburd, B.; Phu, W.; Wilson, M. W.; Laricchia, K. M.; Goodrich, J. K.; Goldstein, D.; Goldstein, J. I.; Vittal, C.; Poterba, T.; Baxter, S.; Watts, N. A.; Solomonson, M.; gnomAD consortium, ; Tiao, G.; Rehm, H. L.; Neale, B. M.; Talkowski, M. E.; MacArthur, D. G.; O'Donnell-Luria, A.; Karczewski, K. J.; Radivojac, P.; Daly, M. J.; Samocha, K. E.
10.1101/2024.04.11.588920 — genomics — Posted on 2024-04-13
2751 Short lifespan is one's fate, long lifespan is one's achievement: lessons from Daphnia
Beam, T. C.; Bright, M. P.; Pearson, A. C.; Dua, I.; Dutta, A. K.; Smith, M. L.; Bhadra, S.; Strickler, C. N.; Salman, S.; Anderson, C. E.; Peshkin, L.; Yampolsky, L. Y.
10.1101/2024.03.30.587428 — ecology — Posted on 2024-04-13
2752 Early-life stress alters postnatal chromatin development in the nucleus accumbens
Rashford, R. L.; DeBerardine, M.; Kim, H. J. J.; Arzouni, N.; Hirschfield, L. W.; Oke, O. M.; Bennett, S. N.; Pena, C. J.
10.1101/2024.04.12.589272 — neuroscience — Posted on 2024-04-13
2753 FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage
Lv, J.; Sun, J.; Luo, Y.; Liu, J.; Wu, D.; Fang, Y.; Lan, H.; Diao, L.; Ma, Y.; Li, Y.; Wang, M.; Zhao, Z.; Wang, H.; Morris, A.; Zhang, W.; Zhang, Z.; Lin, L.; Jia, H.; Wang, C.; Li, T.; Mourou, G.; Huang, S.; Yang, G.; Yan, X.
10.1101/2024.04.10.588811 — biophysics — Posted on 2024-04-13
2754 Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu
Min, C. K.; Nwachukwu, J. C.; Hou, Y.; Russo, R.; Papa, A.; Min, J.; Peng, R.; Kim, S. H.; Zeigler, Y.; Rangarajan, E. S.; Izard, T.; Katzenellenbogen, B. S.; Katzenellenbogen, J. A.; Nettles, K. W.
10.1101/2024.04.10.588871 — biophysics — Posted on 2024-04-13
2755 Altered Mechanobiology of PDAC Cells with Acquired Chemoresistance to Gemcitabine and Paclitaxel.
Gregori, A.; Bergonzini, C.; Capula, M.; Rodrigues de Mercado, R.; Danen, E. H. J.; Giovannetti, E.; Schmidt, T.
10.1101/2024.04.10.588671 — biophysics — Posted on 2024-04-13
2757 E.PathDash, pathway activation analysis of public cystic fibrosis pathogen gene expression data
Taub, L.; Hampton, T. H.; Sarkar, S.; Doing, G.; Neff, S. L.; Finger, C. E.; Fukutani, K. F.; Stanton, B. A.
10.1101/2024.04.10.588749 — bioinformatics — Posted on 2024-04-13
2759 S-Wipe: stool sample collection for metabolomic gut health tracking
Melnik, A. V.; Pobozhev, K.; Lotfi, A.; Moradi, D.; Monahan, H.; Kopylova, E.; Aksenov, A. A.
10.1101/2024.04.12.589313 — biochemistry — Posted on 2024-04-13
2760 A framework for quality control in quantitative proteomics
Tsantilas, K. A.; Merrihew, G. E.; Robbins, J. E.; Johnson, R. S.; Park, J.; Plubell, D. L.; Huang, E.; Riffle, M.; Sharma, V.; MacLean, B. X.; Eckels, J.; Bereman, M. B.; Spencer, S. E.; Hoofnagle, A. N.; MacCoss, M. J.
10.1101/2024.04.12.589318 — biochemistry — Posted on 2024-04-13
2763 Human cytomegalovirus extensively re-organizes the human genome, diminishing TEAD1 transcription factor activity
Sayeed, K.; Parameswaran, S.; Beucler, M. J.; Edsall, L. E.; VonHandorf, A.; Crowther, A.; Donmez, O. A.; Hass, M. R.; Richards, S.; Forney, C. R.; Wright, J.; Leong, M. M.; Murray-Nerger, L. A.; Gewurz, B. E.; Kaufman, K. M.; Harley, J. B.; Zhao, B.; Miller, W. E.; Kottyan, L. C.; Weirauch, M. T.
10.1101/2024.04.12.588762 — genomics — Posted on 2024-04-13
2766 Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations
Li, W.-P.; Su, J.-Y.; Chang, Y.-C.; Wang, Y.-L.; Chiang, H.-L.; Hsieh, Y.-T.; Chiang, Y.-H.; Ko, Y.-L.; Chiang, B.-J.; Yang, C.-H.; Huang, Y.-T.; Lin, C.-L.
10.1101/2024.04.11.589132 — genetics — Posted on 2024-04-13
2767 Four centuries of commercial whaling eroded 11,000 years of population stability in bowhead whales
Westbury, M. V.; Brown, S. C.; Cabrera, A. A.; Morales, H. E.; Ma, J.; Rey-Iglesia, A.; Dyke, A. S.; Scharff-Olsen, C. H.; Scott, M.; Wiig, O.; Bachmann, L.; Kovacs, K. M.; Lydersen, C.; Ferguson, S.; Racimo, F.; Szpak, P.; Fordham, D. A.; Lorenzen, E.
10.1101/2024.04.10.588858 — evolutionary biology — Posted on 2024-04-13
2768 Missing Wedge Completion via Unsupervised Learning with Coordinate Networks
Van Veen, D.; Galaz-Montoya, J. G.; Shen, L.; Baldwin, P.; Chaudhari, A. S.; Lyumkis, D.; Schmid, M. F.; Chiu, W.; Pauly, J.
10.1101/2024.04.12.589090 — molecular biology — Posted on 2024-04-13
2770 CCQM-P199: Interlaboratory comparability study of HIV-1 RNA copy number quantification
Devonshire, A. S.; Busby, E. J.; Jones, G. M.; O'Sullivan, D. M.; Fernandez-Gonzalez, A.; Shibayama, S.; Fujii, S.-i.; Kato, M.; Emerson Leguizamon, J.; Patricia Tere Pena, C.; Mercedes Arias Cortes, M.; Becht Flatschart, R.; Neves de Medeiros, M.; Marcos Saraiva, A.; Bae, Y.-K.; Yang, I.; Yoo, H.-B.; Bogozalec Kosir, A.; Milavec, M.; Dong, L.; Niu, C.; Wang, X.; Morris, P.; Temisak, S.; Cleveland, M. H.; Vallone, P. M.; Burke, D.; Forbes-Smith, M.; McLaughlin, J.; Falak, S.; Hussels, M.; Macdonald, R.; Kummrow, A.; Yalcinkaya, B.; Akyurek, S.; Akgoz, M.; Vonsky, M.; Runov, A.; Morris, C.; Alm
10.1101/2024.04.12.589043 — molecular biology — Posted on 2024-04-13
2772 An intestinal Sir2-HSF1-ATGL1 pathway regulates lipolysis in C. elegans
Somogyvari, M.; Khatatneh, S.; Hajdu, G.; Sotil, B.; Muranyi, J.; Soti, C.
10.1101/2024.04.11.588856 — molecular biology — Posted on 2024-04-13
2774 Quantitative tests of albendazole resistance in beta-tubulin mutants
Collins, J.; Stone, S.; Koury, E.; Paredes, A.; Shao, F.; Lovato, C.; Chen, M.; Shi, R.; Li, A.; Candal, I.; Al Moutaa, K.; Moya, N.; Andersen, E. C.
10.1101/2024.04.11.589070 — molecular biology — Posted on 2024-04-13
2775 Machine learning driven image segmentation and shape clustering of algal microscopic images obtained from various water types
Nelli, F.; Ge, Z.; Blackall, L.; Taheriashtiani, N.; Henry, R.; Brumley, D. R.; Grace, M.; Jex, A.; Burch, M.; Lin, T.-F.; Bertelkamp, C.; Willis, A.; Gao, L.; Schmidt, J.; Crosbie, N. D.; Zamyadi, A.
10.1101/2024.04.13.589342 — microbiology — Posted on 2024-04-13
2776 Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence
Went, S. C.; Picton, D. M.; Morgan, R. D.; Nelson, A.; Dryden, D. T.; Smith, D. L.; Wenner, N.; Hinton, J. C. D.; Blower, T. R.
10.1101/2024.04.12.589231 — microbiology — Posted on 2024-04-13
2777 Ripened plant-based cheese analogs in Europe: nutritional and microbial profiles
Jaeger, I.; Kohn, C. R.; Evans, J. D.; Frazzon, J.; Renault, P.; Kothe, C. I.
10.1101/2024.04.13.589336 — microbiology — Posted on 2024-04-13
2778 Antiviral RNA interference targets viral transcripts but not genomes of RNA viruses in Drosophila melanogaster
Silva, E.; Alvaro, F.; Leite, T.; Faria, I.; Armache, J.; Hass, G.; Martin, F.; Imler, J.-L.; Marques, J.
10.1101/2024.04.10.588985 — immunology — Posted on 2024-04-13
2779 β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents
Gereau, G. B.; Zhou, D.; Van Voorhies, K. J.; Tyler, R. E.; Campbell, J.; Murray, J. G.; Alvararez-Pamir, A.; Wykoff, L.; Companion, M. A.; Jackson, M. R.; Olson, S. H.; Barak, L. S.; Slosky, L. M.; Vetreno, R. P.; Besheer, J.; McElligott, Z. A.
10.1101/2024.04.10.588903 — neuroscience — Posted on 2024-04-13
2780 Sustaining microglial reparative function enhances stroke recovery
Tsuyama, J.; Sakai, S.; Kurabayashi, K.; Koyama, R.; Kawaji, H.; Hara, Y.; Kawakami, I.; Shichita, T.
10.1101/2024.04.10.588813 — pathology — Posted on 2024-04-13
2783 The dorsal fan-shaped body is a neurochemically heterogeneous sleep-regulating center in Drosophila
Jones, J. D.; Holder, B. L.; Montgomery, A. C.; McAdams, C. V.; He, E.; Burns, A. E.; Eiken, K. R.; Vogt, A.; Velarde, A. I.; Elder, A. J.; McEllin, J. A.; Dissel, S.
10.1101/2024.04.10.588925 — neuroscience — Posted on 2024-04-13
2785 Juvenile agile frogs spatially avoid ranavirus-infected conspecifics, but do not show generalized social distancing or self-isolation
Herczeg, D.; Horvath, G.; Bokony, V.; Herczeg, G.; Kasler, A.; Holly, D.; Miko, Z.; Ujhegyi, N.; Ujszegi, J.; Papp, T.; Hettyey, A.
10.1101/2024.04.10.588850 — animal behavior and cognition — Posted on 2024-04-13
2788 Population genomics of Plasmodium ovale species in sub-Saharan Africa
Carey-Ewend, K.; Popkin-Hall, Z. R.; Simkin, A.; Muller, M.; Hennelly, C.; He, W.; Moser, K.; Gaither, C.; Niare, K.; Aghakanian, F.; Feleke, S.; Brhane, B. G.; Phanzu, F.; Mwandagalirwa, K.; Aydemir, O.; Sutherland, C.; Ishengoma, D. S.; Ali, I. M.; Ngasala, B.; Kalonji, A.; Tshefu, A.; Parr, J.; Bailey, J. A.; Juliano, J. J.; Lin, J. T.
10.1101/2024.04.10.588912 — genomics — Posted on 2024-04-13
2789 Current genomic deep learning architectures generalize across grass species but not alleles
Wrightsman, T.; Ferebee, T.; Romay, M. C.; AuBuchon-Elder, T.; Phillips, A. R.; Syring, M.; Kellogg, E. A.; Buckler, E. S.
10.1101/2024.04.11.589024 — genomics — Posted on 2024-04-13
2790 Comparative genomics and transcriptomics reveal differences in effector complement and expression between races of Fusarium oxysporum f. sp. lactucae
Bates, H. J.; Pike, J.; Price, R. J.; Jenkins, S.; Connell, J.; Legg, A.; Armitage, A.; Harrison, R. J.; Clarkson, J. P.
10.1101/2024.04.11.589035 — genomics — Posted on 2024-04-13
2791 Unexpectedly dense colonization of soil pore space by microbes
Schmidt, H.; Schlueter, S.; Raynaud, X.; Felde, V. J.; Zeller-Plumhoff, B.; Richter, A.; Nunan, N.
10.1101/2024.04.10.588810 — ecology — Posted on 2024-04-13
2793 Oct4 redox sensitivity potentiates reprogramming and differentiation
Shen, Z.; Wu, Y.; Mana, A.; Yi, C.; Cairns, B.; Evason, K. J.; Chandrasekharan, M. B.; Tantin, D.
10.1101/2023.02.21.529404 — molecular biology — Posted on 2024-04-13
2794 Mutations in the IgG B cell receptor associated with class-switched B cell lymphomas
Wasim, L.; Chu, S. W. T.; Sale, B.; Pickard, L.; Leonard, S.; Zhang, L.; Tolarova, H.; Tean, Z. S.; Engels, N.; Calado, D. P.; Tarte, K.; Okosun, J.; Forconi, F.; Tolar, P.
10.1101/2024.04.12.585865 — immunology — Posted on 2024-04-13
2796 Colour preference in juvenile European lobster (Homarus gammarus)
Bell, M. E.; Kuvaldina, N.; Frontaura, E. R.; Kuebutornye, F. K. A.; Domech, P. C.; Wan, A. H. L.
10.1101/2024.04.12.588567 — animal behavior and cognition — Posted on 2024-04-13
2797 Chromosome Structure I: Loop extrusion or boundary:boundary pairing?
Bing, X.; Ke, W.; Fujioka, M.; Kurbidaeva, A.; Levitt, S.; Levine, M.; Schedl, P.; Jaynes, J. B.
10.1101/2023.11.17.567501 — genetics — Posted on 2024-04-13
2800 Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses
Cole, M.; Anastasiou, P.; Lee, C.; Moore, C.; Mugarza, E.; Jones, M.; Valand, K.; Rana, S.; Colliver, E.; Angelova, M.; Enfield, K.; Magness, A.; Mullokandov, A.; Kelly, G.; de Gruijl, T.; Molina-Arcas, M.; Swanton, C.; Downward, J.; van Maldegem, F.
10.1101/2024.04.11.588725 — cancer biology — Posted on 2024-04-13
2803 The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)
Chen, J.; Yap, M. C.; Bassot, A.; Pascual, D. M.; Makio, T.; Zimmermann, J.; Mast, H.; Bhat, R.; Fleury, S. G.; Fan, Y.; Zardini Buzatto, A.; Moore, J.; Ballanyi, K.; Li, L.; Overduin, M.; Lemieux, M. J.; Lemieux, H.; Tan, W.-H.; Mancini, G. M. S.; Morgan, B.; Marcogliese, P. C.; Simmen, T.
10.1101/2024.04.12.589228 — cell biology — Posted on 2024-04-13
2804 Defects in exosome biogenesis are associated with sensorimotor defects in zebrafish vps4a mutants
Shipman, A.; Gao, Y.; Liu, D.; Sun, S.; Zang, J.; Sun, P.; Syed, Z.; Bhagavathi, A.; Smith, E.; Erickson, T.; Hill, M.; Neuhauss, S. C.; Sui, S.-F.; Nicolson, T.
10.1101/2024.03.13.584854 — neuroscience — Posted on 2024-04-13
2805 Mechanically Sheared Axially Swept Light-Sheet Microscopy
Lin, J.; Mehra, D.; Marin, Z.; Wang, X.; Borges, H. M.; Shen, Q.; Galecki, S.; Haug, J.; Dean, K. M.
10.1101/2024.04.10.588892 — biophysics — Posted on 2024-04-13
2806 Inhibiting CRF Projections from the Central Amygdala to Lateral Hypothalamus and Amygdala Deletion of CRF Alters Binge-Like Ethanol Drinking in a Sex-Dependent Manner
Bendrath, S.; Mendez, H.; Dankert, A.; Lerma-Cebrera, J. M.; Carvajal, F.; Dornellas-Loper, A. P.; Lee, S.; Neira, S.; Haun, H.; Delpire, E.; Navarro, M. N.; Kash, T.; Thiele, T. E.
10.1101/2024.04.09.588750 — neuroscience — Posted on 2024-04-13
2811 Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay
Batiuk, A.; Höpfler, M.; Almeida, A. C.; En-Jie, D. T.; Vadas, O.; Vartholomaiou, E.; Hegde, R. S.; Lin, Z.; Gasic, I.
10.1101/2024.04.12.589224 — cell biology — Posted on 2024-04-13
2814 Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammation
Saleh, T. A.; Whitson, J. A.; Keiser, P.; Prasad, P.; Jenkins, B. C.; Sodeinde, T.; Mann, C.; Rabinovitch, P. S.; McReynolds, M. R.; Sweetwyne, M. T.
10.1101/2024.04.09.588624 — physiology — Posted on 2024-04-13
2815 Coral long-term recovery after bleaching: implications for sexual reproduction and physiology.
Padilla-Gamino, J.; Timmins-Schiffman, E.; Lenz, E.; White, S. J.; Axworthy, J.; Potter, A.; Lopez, J.; Wang, F.
10.1101/2024.04.09.588789 — physiology — Posted on 2024-04-13
2821 Tumor spheroid elasticity estimation using mechano-microscopy combined with a conditional generative adversarial network
Foo, K. Y.; Shaddy, B.; Murgoitio-Esandi, J.; Hepburn, M. S.; Li, J.; Mowla, A.; Vahala, D.; Amos, S. E.; Choi, Y. S.; Oberai, A. A.; Kennedy, B. F.
10.1101/2024.04.12.589174 — bioengineering — Posted on 2024-04-13
2822 Loading of extracellular vesicles with nucleic acids via hybridization with sponge-like lipid nanoparticles
Bader, J.; Rüedi, P.; Mantella, V.; Geisshüsler, S.; Brigger, F.; Qureshi, B. M.; Ortega Arroyo, J.; Montanari, E.; Leroux, J.-C.
10.1101/2024.04.10.588678 — bioengineering — Posted on 2024-04-13
2823 The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization
Oates, T. C. L.; Boyd, J.; Dolan, L.; de Kergariou, C.; Toye, A. M.; Perriman, A. W.; Boussahel, A.
10.1101/2024.04.10.588451 — bioengineering — Posted on 2024-04-13
2824 Three years of insecticide resistance evolution and associated mechanisms in Aedes aegypti populations of Ouagadougou, Burkina Faso.
Yameogo, F.; Sombie, A.; Ote, M.; Saiki, E.; Sakurai, T.; Wangrawa, D. W.; McCall, P. J.; Weetman, D.; Kanuka, H.; Badolo, A.
10.1101/2024.04.09.588738 — evolutionary biology — Posted on 2024-04-13
2826 Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns
Stevens, J.; Culberson, E.; Kinder, J.; Ramiriqui, A. R.; Gray, J.; Bonfield, M.; Shao, T.-y.; Al Gharabieh, F.; Peterson, L.; Steinmeyer, S.; Zacharias, W. J.; Pryhuber, G.; Paul, O.; Sengupta, S.; Alenghat, T.; Way, S. S.; Deshmukh, H.
10.1101/2024.04.09.588427 — immunology — Posted on 2024-04-13
2827 Cytomegalovirus inhibitors of programmed cell death prevent a contribution of antigen cross-presentation to the priming of antiviral CD8 T cells
Ebert, S.; Böhm, V.; Büttner, J. K.; Brune, W.; Brinkmann, M. M.; Holtappels, R.; Reddehase, M. J.; Lemmermann, N. A.
10.1101/2024.04.09.588745 — immunology — Posted on 2024-04-13
2830 A stress-dependent TDP-43 SUMOylation program preserves neuronal function
Suk, T. R.; Part, C. E.; Nguyen, T. T.; Zhang, J. L.; Heer, M. M.; Caballero-Gomez, A.; Grybas, V. S.; McKeever, P. M.; Nguyen, B.; Callaghan, S. M.; Woulfe, J. M.; Robertson, J.; Rousseaux, M. W. C.
10.1101/2024.04.12.589206 — neuroscience — Posted on 2024-04-13
2831 Computational functions of precisely balanced neuronal assemblies in an olfactory memory network
Meissner-Bernard, C.; Jenkins, B.; Rupprecht, P.; Arn Bouldoires, E.; Zenke, F.; Friedrich, R. W.; Frank, T.
10.1101/2024.04.09.588702 — neuroscience — Posted on 2024-04-13
2833 Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms in mice
Taib, S.; Durand, J.; Boulay, A.-C.; Dehais, V.; Martin, S.; Blugeon, C.; Jourdren, L.; Cohen-Salmon, M.; Hazan, J.; Brunet, I. V.
10.1101/2024.04.09.588709 — neuroscience — Posted on 2024-04-13
2838 Electrophysiological correlates of lucid dreaming
Demirel, C.; Gott, J.; Appel, K.; Lueth, K.; Fischer, C.; Raffaelli, C.; Westner, B.; Zavecz, Z.; Steiger, A.; Mota-Rolim, S.; Ribeiro, S.; Zeising, M.; Adelhoefer, N.; Dresler, M.
10.1101/2024.04.09.588765 — neuroscience — Posted on 2024-04-13
2841 Impact of Prescribed Fire on Soil Microbial Communities in a Southern Appalachian Forest Clearcut
Rafie, S. A. A.; Blentlinger, L. R.; Putt, A. D.; Williams, D. E.; Campa, M. F.; Joyner, D. C.; Schubert, M. J.; Hoyt, K. P.; Horn, S. P.; Franklin, J. A.; Hazen, T. C.
10.1101/2024.04.09.588751 — systems biology — Posted on 2024-04-13
2842 All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis
Rao, A.; Zhang, X.; Cillo, A.; Sussman, J. H.; Sandlesh, P.; Tarbay, A. C.; Mallela, A. N.; Cardello, C.; Krueger, K.; Xu, J.; Li, A.; Xu, J.; Patterson, J.; Akca, E.; Angione, A.; Jaman, E.; Kim, W. J.; Allen, J.; Venketeswaran, A.; Zinn, P. O.; Parise, R.; Beumer, J.; Duensing, A.; Holland, E. C.; Ferris, R.; Bagley, S. J.; Bruno, T. C.; Vignali, D. A. A.; Agnihotri, S.; Amankulor, N. M.
10.1101/2024.04.09.588752 — cancer biology — Posted on 2024-04-13
2843 PGC-1α drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity
Varuzhanyan, G.; Chen, C.-C.; Freeland, J.; He, T.; Tran, W.; Song, K.; Wang, L.; Cheng, D.; Xu, S.; Dibernardo, G. A.; Esedebe, F. N.; Abt, E. R.; Park, J. W.; Memarzadeh, S.; Graeber, T.; Shirihai, O.; Witte, O. N.
10.1101/2024.04.09.588489 — cancer biology — Posted on 2024-04-13
2844 Human Cells for Human Proteins: Isotope Labeling in Mammalian Cells for Functional NMR Studies of Disease-Relevant Proteins
Rössler, P.; Ruckstuhl, M.; Löbbert, A.; Stühlinger, T.; Franchini, L. R.; Tsai, C.-J.; Lichtenecker, R.; Shrestha, B.; Rüdisser, S. H.; Konrat, R.; Schertler, G. F. X.; Gossert, A. D.
10.1101/2024.04.09.588766 — biophysics — Posted on 2024-04-13
2849 Comparative modeling reveals the molecular determinants of aneuploidy fitness cost in a wild yeast model
Rojas, J.; Hose, J.; Dutcher, H. A.; Place, M.; Wolters, J. F.; Hittinger, C. T.; Gasch, A.
10.1101/2024.04.09.588778 — genomics — Posted on 2024-04-13
2850 Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia
Stephenson, R. A.; Johnson, K. R.; Cheng, L.; Yang, L. G.; Root, J. T.; Gopalakrishnan, J.; Shih, H.-Y.; Narayan, P. S.
10.1101/2024.04.11.589145 — cell biology — Posted on 2024-04-13
2852 The chromatin conformation landscape of Alzheimer's disease
Nativio, R.; Lan, Y.; Donahue, G.; Shcherbakova, O.; Barnett, N.; Titus, K. R.; Chandrashekar, H.; Phillips-Cremins, J. E.; Bonini, N. M.; Berger, S. L.
10.1101/2024.04.09.588722 — neuroscience — Posted on 2024-04-13
2855 Glutamylation imbalance leads to photoreceptor degeneration
Mercey, O.; Gadadhar, S.; Magiera, M. M.; Lebrun, L.; Kostic, C.; Moulin, A.; Arsenijevic, Y.; Janke, C.; Guichard, P.; Hamel, V.
10.1101/2024.04.09.588666 — cell biology — Posted on 2024-04-13
2856 A Lipidomics-Based Method to Eliminate Negative Urine Culture in General Population
Nartey, L. K.; Mikhael, A.; Petro?ova, H.; Yuen, V.; Kibsey, P.; Ernst, R. K.; Chen, M. X.; Goodlett, D. R.
10.1101/2024.04.11.589091 — microbiology — Posted on 2024-04-13
2858 MAJOR METABOLITES FROM HYPERICUM PERFORATUM L., HYPERFORIN AND HYPERICIN, ARE BOTH ACTIVE AGAINST HUMAN CORONAVIRUSES
Raczkiewicz, I.; Riviere, C.; Bouquet, P.; Desmarets, L.; Tarricone, A.; Camuzet, C.; Francois, N.; Lefevre, G.; Samaillie, J.; Silva Angulo, F.; Robil, C.; Trottein, F.; Sahpaz, S.; Dubuisson, J. D.; Belouzard, S.; Goffard, A.; Seron, K.
10.1101/2024.04.09.588755 — microbiology — Posted on 2024-04-13
2859 Brilacidin, a novel antifungal agent against Cryptococcus neoformans
Diehl, C.; Pinzan, C. F.; de Castro, P. A.; Delbaje, E.; Carnero, L. G.; Sanchez-Leon, E.; Bhalla, K.; Kronstad, J. W.; Kim, D.-g.; Doering, T. L.; Alkhazraji, S.; Mishra, N. N.; Ibrahim, A. S.; Yoshimura, M.; Isuhuayla, L. A. V.; Pham, L. T.; Yashiroda, Y.; Boone, C.; dos Reis, T. F.; Goldman, G. H.
10.1101/2024.04.10.588976 — microbiology — Posted on 2024-04-13
2861 A Large Field-of-view, Single-cell-resolution Two- and Three-Photon Microscope for Deep Imaging
Mok, A.; Wang, T.; Zhao, S.; Kolkman, K.; Wu, D.; Ouzounov, D.; Seo, C.; Wu, C.; Fetcho, J.; Xu, C.
10.1101/2023.11.14.566970 — neuroscience — Posted on 2024-04-13
2863 Molecular architecture of synaptic vesicles.
Kravcenko, U.; Ruwolt, M.; Kroll, J.; Yushkevich, A.; Zenkner, M.; Ruta, J.; Lotfy, R.; Wanker, E. E.; Rosenmund, C.; Liu, F.; Kudryashev, M.
10.1101/2024.04.11.588828 — biophysics — Posted on 2024-04-13
2867 Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment
Prowse, E. N. P.; Turkalj, B. A.; Sebastien, M.; Beaudet, D.; McBride, H. M.; Brouhard, G. J.; Pouladi, M. A.; Hendricks, A. G.
10.1101/2024.04.12.589210 — cell biology — Posted on 2024-04-12
2872 Targeting of a STING Agonist to Perivascular Macrophages in Prostate Tumors Delays Resistance to Androgen Deprivation Therapy
Al-janabi, H.; Moyes, K.; Allen, R. J.; Fisher, M.; Crespo, M.; Gurel, B.; Rescigno, P.; De Bono, J.; Nunns, H.; Bailey, C.; Juncker-Jensen, A.; Muthana, M.; Phillips, W. A.; Pearson, H.; Taplin, M.-E.; Brown, J. E.; Lewis, C. E.
10.1101/2024.04.11.589003 — cancer biology — Posted on 2024-04-12
2873 The G-Protein Couple Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis
Asensio, A.; Sanz-Flores, M.; Liakath-Ali, K.; Palacios, J.; Paramio, J. M.; Garcia-Escudero, R.; Mayor, F.; Ribas, C.
10.1101/2024.04.11.589052 — cell biology — Posted on 2024-04-12
2875 Cerebro-spinal somatotopic organization uncoveredthrough functional connectivity mapping
Landelle, C.; Kinany, N.; De Leener, B.; Murphy, N. D.; Lungu, O.; Marchand-Pauvert, V.; Van De Ville, D.; Doyon, J.
10.1101/2024.04.11.588866 — neuroscience — Posted on 2024-04-12
2879 Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies
Zaidi, S.; Park, J.; Chan, J. M.; Roudier, M.; Zhao, J. L.; Gopalan, A.; Wadosky, K. M.; Patel, R. A.; Sayar, E.; Karthaus, W. R.; Kates, D. H.; Chaudhary, O.; Xu, T.; Masilionis, I.; Mazutis, L.; Chaligne, R.; Obradovic, A.; Linkov, I.; Barlas, A.; Jungbluth, A.; Rekhtman, N.; Silber, J.; Manova-Todorova, K.; Watson, P. A.; True, L. D.; Morrissey, C. M.; Scher, H. I.; Rathkopf, D.; Morris, M. J.; Goodrich, D. W.; Choi, J.; Nelson, P. S.; Haffner, M.; Sawyers, C.
10.1101/2024.04.09.588340 — cancer biology — Posted on 2024-04-12
2880 Integrative multi-omic analysis identifies genes associated with cuticular wax biogenesis in adult maize leaves
Lin, M.; Bacher, H.; Bourgault, R.; Qiao, P.; Matschi, S.; Vasquez, M. F.; Mohammadi, M.; van Boerdonk, S.; Scanlon, M. J.; Smith, L. G.; Molina, I.; Gore, M. A.
10.1101/2024.04.09.588685 — genetics — Posted on 2024-04-12
2884 Molecular basis of foreign DNA recognition by BREX anti-phage immunity system
Drobiazko, A.; Adams, M.; Skutel, M.; Kristina, P.; Matlashov, M.; Maxwell, K. L.; Blower, T. R.; Severinov, K.; Ghilarov, D.; Isaev, A.
10.1101/2024.04.12.589305 — molecular biology — Posted on 2024-04-12
2886 Cardiovascular symptoms of PASC are associated with trace-level cytokines that affect the function of human pluripotent stem cell derived cardiomyocytes
Sinclair, J.; Vedelago, C.; Ryan, F.; Carney, M.; Redd, M.; Lynn, M.; Grubor-Bauk, B.; Cao, Y.; Henders, A.; Chew, K. Y.; Gilroy, D.; Greaves, K.; Labzin, L.; Ziser, L.; Ronacher, K.; Wallace, L.; Zhang, Y.; Macauslane, K.; Ellis, D.; Rao, S.; Burr, L.; Bain, A.; Schulz, B. L.; Li, J.; Lynn, D. J.; Palpant, N.; Wuethrich, A.; Trau, M.; Short, K.
10.1101/2024.04.11.587623 — microbiology — Posted on 2024-04-12
2888 On-farm biomass recycling with biostimulant Re-Gen increases corn yields in multi-year farm trials
Gibson, W. S.; Ziobron, A. S.; Olson, N. E.; Neher, D. A.; Smith, C. F.; Holden, V. I.
10.1101/2024.04.12.589288 — microbiology — Posted on 2024-04-12
2889 Macrolide resistance through uL4 and uL22 ribosomal mutations in Pseudomonas aeruginosa
Goltermann, L.; Laborda, P.; Irazoqui, O.; Pogrebnyakov, I.; Molin, S.; Johansen, H. K.; La Rosa, R.
10.1101/2024.04.11.588999 — microbiology — Posted on 2024-04-12
2892 Non-sulfate-based hydrogen sulfide production in engineered systems
Nguyen-tiet, A. M.; Puente-Sanchez, F.; Bertilsson, S.; Aalto, S. L.
10.1101/2024.04.12.589155 — microbiology — Posted on 2024-04-12
2893 Fetal programming by the maternal microbiome of offspring behavior, and DNA methylation and gene expression within the hippocampus
Gustafson, K. L.; Busi, S. B.; McAdams, Z. L.; McCorkle, R. E.; Khodakivskyi, P.; Bivens, N. J.; Davis, D. J.; Raju, M.; Coghill, L. M.; Goun, E. A.; Amos-Landgraf, J.; Franklin, C. L.; Wilmes, P.; Cortese, R.; Ericsson, A. C.
10.1101/2024.04.12.589237 — microbiology — Posted on 2024-04-12
2894 A sequence- and structure-based characterization of microbial enzymes identifies P. stutzeri as a plastic-degrading species
Hong, A.; Turner, S.; Glazer, R.; Weishampel, Z. A.; Vispute, A.; Huang, A.; Holmes, Z. A.; Schleupner, B.; Dunphy-Daly, M. M.; Eward, W. C.; Somarelli, J. A.
10.1101/2024.04.12.589142 — microbiology — Posted on 2024-04-12
2895 Affective Symptoms in Pregnancy are Associated with the Vaginal Microbiome
Scheible, K.; Beblavy, R.; Sohn, M. B.; Qiu, X.; Gill, A. L.; Narvaez miranda, J.; Brunner, J.; Miller, R. K.; Barrett, E. S.; O'Connor, T. G.; Gill, S.
10.1101/2024.04.12.589254 — microbiology — Posted on 2024-04-12
2896 High-throughput Tn-seq screens identify both known and novel Pseudomonas putida KT2440 genes involved in metal resistance
Royet, K.; Kergoat, L.; Lutz, S.; Oriol, C.; Parisot, N.; Schori, C.; Ahrens, C. H.; Rodrigue, A.; Gueguen, E.
10.1101/2024.04.12.589247 — microbiology — Posted on 2024-04-12
2898 Simultaneous detection of pathogens and antimicrobial resistance genes with the open source, cloud-based, CZ ID pipeline
Lu, D.; Kalantar, K. L.; Chu, V. T.; Glascock, A. L.; Guerrero, E. S.; Bernick, N.; Butcher, X.; Ewing, K.; Fahsbender, E.; Holmes, O.; Hoops, E.; Jones, A. E.; Lim, R.; McCanny, S.; Reynoso, L.; Rosario, K.; Tang, J.; Valenzuela, O.; Mourani, P. M.; Pickering, A. J.; Raphenya, A. R.; Alcock, B. P.; McArthur, A. G.; Langelier, C. R.
10.1101/2024.04.12.589250 — microbiology — Posted on 2024-04-12
2901 Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing
Bartas, K.; Hui, M.; Derdeyn, P.; Tian, G.; Vasquez, J. J.; Azouz, G.; Yamamoto, C. M.; Beier, K.
10.1101/2022.12.16.520804 — neuroscience — Posted on 2024-04-12
2902 Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction.
Fournier, L. A.; Phadke, R. A.; Salgado, M.; Brack, A.; Nocon, J. C.; Bolshakova, S.; Grant, J. R.; Padro Luna, N. M.; Sen, K.; Cruz Martin, A.
10.1101/2024.01.27.575409 — neuroscience — Posted on 2024-04-12
2903 Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis.
Robertson, K.; Hahn, O.; Robinson, B. G.; Faruk, A. T.; Janakiraman, M.; Namkoong, H.; Kim, K.; Ye, J.; Bishop, E. S.; Hall, R. A.; Wyss-Coray, T.; Becker, L. S.; Kaltschmidt, J. A.
10.1101/2024.04.09.588619 — neuroscience — Posted on 2024-04-12
2904 Satellite glial cells from adult DRG dedifferentiate in vitro and can be reprogrammed into nociceptor-like neurons
Sodmann, A.; Koehler, N.; Esfahani, N. M.; Schuhkraft, N.; Aue, A.; Jager, S. E.; Bischler, T.; Imdahl, F.; Graefenhan, T.; Leipold, E.; Rittner, H. L.; Blum, R.
10.1101/2024.04.09.588701 — neuroscience — Posted on 2024-04-12
2906 Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis
Shah, A. P.; Majeti, K. R.; Ekman, F. K.; Selvaraj, S.; Soupene, E.; Chati, P.; Sinha, R.; Luna, S. E.; Charlesworth, C. T.; McCreary, T.; Lesch, B. J.; Sharma, D.; Chu, S. N.; Porteus, M. H.; Cromer, M. K.
10.1101/2024.04.12.589260 — synthetic biology — Posted on 2024-04-12
2907 Kinase Suppressor of Ras 2 promotes small-cell lung carcinoma tumor initiation
Huisman, D. H.; Chatterjee, D.; Svoboda, R. A.; Vieira, H. M.; Skupa, S.; Askew, J. W.; Frodyma, D. E.; Girard, L.; Fisher, K. W.; Kareta, M.; Minna, J.; Oliver, T. G.; Lewis, R. E.
10.1101/2022.02.11.480157 — cancer biology — Posted on 2024-04-12
2908 Dual targeting of mitochondrial Lon peptidase 1 and chymotrypsin-like protease by small molecule BT317, as potential therapeutics in malignant astrocytoma
Douglas, C. R.; Jain, S.; Lomeli, N.; Lepe, J.; Di, K.; Nandwana, N. K.; Vu, T.; Pham, J.; Kenney, M. C.; Das, B.; Bota, D.
10.1101/2023.04.13.536816 — cancer biology — Posted on 2024-04-12
2909 CDC42 Inhibitors Alter Patterns of Vessel Arborization in Skin and Tumors in vivo
Vuong, L. M.; Hachey, S. J.; Shiu, J.; Xie, D. F.; Salvador, N.; Brindani, N.; Bertozzi, S. M.; Summa, M.; Bertorelli, R.; Armirotti, A.; Pham, R.; Ku, V. S.; Nguyen, T.; Choi, B.; Hughes, C. C.; De Vivo, M.; Ganesan, A. K.
10.1101/2024.04.09.588609 — cancer biology — Posted on 2024-04-12
2911 Efficient inference of large pangenomes with PanTA
Le, D. Q.; Nguyen, T. A.; Nguyen, S. H.; Nguyen, T. T.; Nguyen, C. H.; Phung, H. T.; Ho, T. H.; Vo, N. S.; Nguyen, T.; Nguyen, H. A.; Cao, M. D.
10.1101/2023.07.03.547471 — bioinformatics — Posted on 2024-04-12
2914 Essential and virulence-related protein interactions of pathogens revealed through deep learning
Humphreys, I. R.; Zhang, J.; Baek, M.; Wang, Y.; Krishnakumar, A.; Pei, J.; Anishchenko, I.; Tower, C. A.; Jackson, B. A.; Warrier, T.; Hung, D. T.; Peterson, S. B.; Mougous, J. D.; Cong, Q.; Baker, D.
10.1101/2024.04.12.589144 — biochemistry — Posted on 2024-04-12
2915 A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice, Wiki and Databases.
Tesson, F.; Planel, R.; Egorov, A. A.; Georjon, H.; Vaysset, H.; Brancotte, B.; Neron, B.; Mordret, E.; Atkinson, G. C.; Bernheim, A.; Cury, J.
10.1101/2024.01.25.577194 — genomics — Posted on 2024-04-12
2916 High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus
Nigrovic, P. A.; Wang, Q.; Kim, T.; Martinez-Bonet, M.; Aguiar, V. R. C.; Sim, S.; Cui, J.; Sparks, J. A.; Chen, X.; Todd, M.; Wauford, B.; Marion, M. C.; Langefeld, C. D.; Weirauch, M. T.; Gutierrez-Arcelus, M.
10.1101/2023.08.16.553538 — genetics — Posted on 2024-04-12
2920 Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.
Oorloff, M.; Hruby, A.; Averbukh, M.; Alcala, A.; Dutta, N.; Castro Torres, T.; Moaddeli, D.; Vega, M.; Kim, J.; Bong, A.; Coakley, A. J.; Hicks, D.; Wang, J.; Wang, T.; Hoang, S.; Tharp, K. M.; Garcia, G.; Sanabria, R.
10.1101/2024.04.11.589121 — cell biology — Posted on 2024-04-12
2921 Resistance to Naive and Formative Pluripotency Conversion in RSeT Human Embryonic Stem Cells
Chen, K. G.; Johnson, K. J.; Park, K.; Maric, D.; Yang, F.; Liu, W. F.; Fann, Y. C.; Mallon, B. S.; Robey, P. G.
10.1101/2024.02.16.580778 — cell biology — Posted on 2024-04-12
2924 A multiplex of connectome trajectories enables several connectivity patterns in parallel
Mostame, P.; Wirsich, J.; Alderson, T. H.; Ridley, B.; Giraud, A.-L.; Carmichael, D.; Vulliemoz, S.; Guye, M.; Lemieux, L.; Sadaghiani, S.
10.1101/2022.06.17.496647 — neuroscience — Posted on 2024-04-12
2925 Developing forebrain synapses are uniquely vulnerable to sleep loss
Gay, S. M.; Chartampila, E.; Lord, J. S.; Grizzard, S.; Maisashvili, T.; Ye, M.; Barker, N. K.; Mordant, A. L.; Mills, C. A.; Herring, L. E.; Diering, G. H.
10.1101/2023.11.06.565853 — neuroscience — Posted on 2024-04-12
2931 HYENA detects oncogenes activated by distal enhancers in cancer
Yu, A.; Yesilkanal, A. E.; Thakur, A.; Wang, F.; Yang, Y.; Phillips, W.; Wu, X.; Muir, A.; He, X.; Spitz, F.; Yang, L.
10.1101/2023.01.09.523321 — cancer biology — Posted on 2024-04-12
2934 The unusual structural properties and potential biological relevance of switchback DNA
Madhanagopal, B. R.; Talbot, H.; Rodriguez, A.; Louis, J. M.; Zeghal, H.; Vangaveti, S.; Reddy, K.; Chandrasekaran, A. R.
10.1101/2023.11.15.563609 — bioengineering — Posted on 2024-04-12
2936 Structure and dynamics determine G protein coupling specificity at a class A GPCR
Casiraghi, M.; Wang, H.; Brennan, P.; Habrian, C.; Hubner, H.; Schmidt, M. F.; Maul, L.; Pani, B.; Bahriz, S. M.; Xu, B.; White, E.; Sunahara, R. K.; Xiang, Y. K.; Lefkowitz, R. J.; Isacoff, E. Y.; Nucci, N.; Gmeiner, P.; Lerch, M.; Kobilka, B. K.
10.1101/2024.03.28.587240 — molecular biology — Posted on 2024-04-12
2937 Transcriptomic Changes in Oligodendrocyte Lineage Cells During the Juvenile to Adult Transition in the Mouse Corpus Callosum
Hoshino, T.; Takase, H.; Hamanaka, G.; Kimura, S.; Fukuda, N.; Mandeville, E. T.; Lok, J.; Lo, E. H.; Arai, K.
10.1101/2024.03.28.587148 — neuroscience — Posted on 2024-04-12
2940 Feasibility of decoding covert speech in ECoG with aTransformer trained on overt speech
Komeiji, S.; Mitsuhashi, T.; Iimura, Y.; Suzuki, H.; Sugano, H.; Shinoda, K.; Tanaka, T.
10.1101/2024.02.05.578911 — neuroscience — Posted on 2024-04-12
2941 Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans
Russo, S.; Claar, L.; Marks, L.; Krishnan, G.; Furregoni, G.; Zauli, F. M.; Hassan, G.; Solbiati, M.; d'Orio, P.; Mikulan, E.; Sarasso, S.; Rosanova, M.; Sartori, I.; Bazhenov, M.; Pigorini, A.; Massimini, M.; Koch, C.; Rembado, I.
10.1101/2024.01.31.578243 — neuroscience — Posted on 2024-04-12
2943 Fibroblast Stromal Support Model for Predicting Human Papillomavirus-Associated Cancer Drug Responses.
James, C. D.; Lewis, R. L.; Fakunmoju, A. L.; Witt, A.; Youssef, A. H.; Wang, X.; Rais, N. M.; Tadimari Prabhakar, A.; Otoa, R.; Bristol, M. L.
10.1101/2024.04.09.588680 — cancer biology — Posted on 2024-04-12
2946 The G1/S transition is promoted by Rb degradation via the E3 ligase UBR5
Zhang, S.; Valenzuela, L. F.; Zatulovskiy, E.; Mangiante, L. F. S.; Curtis, C.; Skotheim, J.
10.1101/2023.10.03.560768 — cell biology — Posted on 2024-04-12
2947 High-Dimensional Imaging of Vestibular Schwannoma Reveals Distinctive Immunological Networks Across Histomorphic Niches in NF2-related Schwannomatosis
Jones, A. P.; Haley, M. J.; Gregory, G. E.; Hannan, C. J.; Simmons, A. K.; Bere, L. D.; Lewis, D. G.; Oliveira, P.; Smith, M. J.; King, A. T.; Evans, D. G.; Paszek, P.; Brough, D.; Pathmanaban, O. N.; Couper, K.
10.1101/2024.04.09.588593 — immunology — Posted on 2024-04-12
2948 RT-Sort: an action potential propagation-based algorithm for real time spike detection and sorting with millisecond latencies
van der Molen, T.; Lim, M.; Bartram, J.; Cheng, Z.; Robbins, A.; Parks, D. F.; Petzold, L. R.; Hierlemann, A.; Haussler, D.; Hansma, P. K.; Tovar, K. R.; Kosik, K. K.
10.1101/2024.04.08.588620 — neuroscience — Posted on 2024-04-12
2951 Leptin Activated Hypothalamic BNC2 Neurons Acutely Suppress Food Intake
Tan, H. L.; Yin, L.; Tan, Y.; Ivanov, J.; Plucinska, K.; Ilanges, A.; Herb, B. R.; Wang, P.; Kosse, C.; Cohen, P.; Lin, D.; Friedman, J. M.
10.1101/2024.01.25.577315 — neuroscience — Posted on 2024-04-12
2952 A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells
Wang, M.; Graner, A.; Knowles, B.; McRae, C.; Fringuello, A.; Paucek, P.; Gavrilovic, M.; Redwine, M.; Coughlan, C.; Hanson, C.; Metzger, B.; Bolus, V.; Kopper, T.; Smith, M.; Zhou, W.; Lenz, M.; Abosch, A.; Ojemann, S.; Lillehei, K.; Yu, X.; Graner, M. W.
10.1101/2024.04.08.588622 — cancer biology — Posted on 2024-04-12
2954 Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis
St. Pierre, L.; Berhan, A.; Sung, E. K.; Alvarez, J. R.; Wang, H.; Ji, Y.; Liu, Y.; Yu, H. V.; Meier, A.; Afshar, K.; Golts, E.; Lin, G. Y.; Castaldi, A.; Calvert, B.; Ryan, A.; Zhou, B.; Offringa, I.; Marconett, C. N.; Borok, Z.
10.1101/2024.04.05.588292 — bioinformatics — Posted on 2024-04-12
2956 Identify compound-protein interaction with knowledge graph embedding of perturbation transcriptomics
Ni, S.; Kong, X.; Zhang, Y.; Chen, Z.; Wang, Z.; Fu, Z.; Huo, R.; Tong, X.; Qu, N.; Wu, X.; Wang, K.; Zhang, W.; Zhang, R.; Zhang, Z.; Shi, J.; Wang, Y.; Yang, R.; Li, X.; Zhang, S.; Zheng, M.
10.1101/2024.04.08.588632 — bioinformatics — Posted on 2024-04-12
2960 Using Eye Gaze to Train an Adaptive Myoelectric Interface
Chou, A. H. Y.; Madduri, M.; Li, S. J.; Isa, J.; Christensen, A.; Hutchison, F. L.; Burden, S. A.; Orsborn, A. L.
10.1101/2024.04.08.588608 — bioengineering — Posted on 2024-04-12
2962 A Small Multidrug Resistance Transporter in Pseudomonas aeruginosa Confers Substrate-Specific Resistance or Susceptibility
Wegrzynowicz, A. K.; Heelan, W. J.; Demas, S. P.; McLean, M. S.; Peters, J. M.; Henzler-Wildman, K. A.
10.1101/2023.09.28.560013 — biochemistry — Posted on 2024-04-12
2965 Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice
Hale, M.; Takehara, K. K.; Thouvenel, C. D.; Moustafa, D. A.; Repele, A.; Fontana, M. F.; Netland, J.; McNamara, S.; Gibson, R. L.; Goldberg, J. B.; Rawlings, D. J.; Pepper, M.
10.1101/2024.04.08.588618 — immunology — Posted on 2024-04-12
2966 ACSS2 contributes to transcriptional regulation in Cajal-Retzius cells in a mouse model of Alzheimer's disease
Egervari, G.; Alexander, D. C.; Donahue, G.; Huang, H.; Hogan, C.; Mendoza, M.; Garcia, B. A.; Bonini, N. M.; Berger, S. L.
10.1101/2024.04.08.588604 — neuroscience — Posted on 2024-04-12
2967 Repeated LPS induces training and tolerance of microglial responses across brain regions
Kim, J.; Sullivan, O.; Lee, K.; Jao, J.; Tamayo, J.; Madany, A. M.; Wong, B.; Ashwood, P.; Ciernia, A. V.
10.1101/2024.04.08.588502 — neuroscience — Posted on 2024-04-12
2968 A deep learning-based approach for unbiased kinematic analysis in CNS injury
Ascona, M.; Tieu, E. K.; Gonzalez-Vega, E.; Liebl, D. J.; Brambilla, R.
10.1101/2024.04.08.588606 — neuroscience — Posted on 2024-04-12
2969 Dopamine D2R and opioid MOR availability in autism spectrum disorder
Noppari, T.; Tuisku, J.; Lukkarinen, L.; Tani, P.; Lindberg, N.; Saure, E.; Lauerma, H.; Tiihonen, J.; Hirvonen, J.; Helin, S.; Rajander, J.; Salmi, J.; Nummenmaa, L.
10.1101/2024.04.09.588651 — neuroscience — Posted on 2024-04-12
2971 Angiotensin-(1-5) is a Potent Endogenous Angiotensin AT2-Receptor Agonist
Souza-Silva, I. M.; Peluso, A. A.; Elsaafien, K.; Nazarova, A. L.; Assersen, K. B.; Rodrigues-Ribeiro, L.; Mohammed, M.; Rodrigues, A. F.; Nawrocki, A.; Johansen, L. A.; Jensen, P.; de Kloet, A. D.; Krause, E. G.; DelBorgo, M.; Maslov, I.; Widdop, R. E.; Santos, R. A. S.; Bader, M.; Larsen, M. R.; Verano-Braga, T.; Katritch, V.; Sumners, C.; Steckelings, U. M.
10.1101/2024.04.05.588367 — pharmacology and toxicology — Posted on 2024-04-12
2973 Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma
Ghoshal, D.; Petersen, I.; Ringquist, R.; Kramer, L.; Bhatia, E.; Hu, T.; Richard, A.; Park, R.; Corbin, J.; Agarwal, S.; Thomas, A.; Ramirez, S.; Tharayil, J.; Downey, E.; Ketchum, F.; Ochal, A.; Sonthi, N.; Lonial, S.; Kochenderfer, J. N.; Tran, R.; Zhu, M.; Lam, W. A.; Coskun, A. F.; Roy, K.
10.1101/2024.04.08.588601 — cancer biology — Posted on 2024-04-12
2974 Automated, image-based quantification of peroxisome characteristics with perox-per-cell
Neal, M. L.; Shukla, N.; Mast, F. D.; Farre, J.-C.; Pacio, T. M.; Raney-Plourde, K. E.; Prasad, S.; Subramani, S.; Aitchison, J. D.
10.1101/2024.04.08.588597 — bioinformatics — Posted on 2024-04-12
2978 Evolution of Large Eyes in Stromboidea (Gastropoda): Impact of Photic Environment and Life History Traits
Irwin, A. R.; Roberts, N. W.; Strong, E. E.; Kano, Y.; Speiser, D. I.; Harper, E. M.; Williams, S. T.
10.1101/2024.04.09.588691 — evolutionary biology — Posted on 2024-04-12
2980 Drug-loaded nanoparticles for cancer therapy: a high-throughput multicellular agent-based modeling study
Wang, Y.; Bucher, E.; Rocha, H.; Jadhao, V.; Metzcar, J.; Heiland, R.; Frieboes, H. B.; Macklin, P.
10.1101/2024.04.09.588498 — systems biology — Posted on 2024-04-12
2981 Widespread exposure to SARS-CoV-2 in wildlife communities
Goldberg, A. R.; Langwig, K. E.; Brown, K. L.; Marano, J. M.; Rai, P.; King, K. M.; Sharp, A. K.; Ceci, A.; Kailing, C. D.; Kailing, M. J.; Briggs, R.; Urbano, M. G.; Roby, C.; Brown, A. M.; Weger-Lucarelli, J.; Finkielstein, C. V.; Hoyt, J. R.
10.1101/2022.11.04.515237 — ecology — Posted on 2024-04-12
2985 DCLK1-Mediated Regulation of Invadopodia Dynamics and Matrix Metalloproteinase Trafficking Drives Invasive Progression in Head and Neck Squamous Cell Carcinoma
Arnold, L.; Yap, M. K.; Jackson, L. K.; Ly, T. K.; Morrison, A. K.; Washburn, M.; Standing, D.; Gomez, J.; Yellap, N. K.; Li, L.; Umar, S.; Anant, S.; Thomas, S. M.
10.1101/2024.04.06.588339 — cancer biology — Posted on 2024-04-12
2989 Ice thickness control and measurement in the VitroJet for time-efficient single particle structure determination
Henderikx, R. J. M.; Schotman, M. J. G.; Shahzad, S.; Fromm, S. A.; Mann, D.; Hennies, J.; Heidler, T. V.; Ashtiani, D.; Hagen, W. J. H.; Jeurissen, R. J. M.; Mattei, S.; Peters, P. J.; Sachse, C.; Beulen, B. W. A. M. M.
10.1101/2023.10.09.561488 — molecular biology — Posted on 2024-04-12
2992 Electromagnetic Modeling within a Microscopically Realistic Brain - Implications for Brain Stimulation
Qi, Z.; Noetscher, G. M.; Miles, A.; Weise, K.; Knosche, T.; Cadman, C. R.; Potashinsky, A. R.; Liu, K.; Wartman, W. A.; Nunez Ponasso, G. C.; Bikson, M.; Lu, H.; Deng, Z.-D.; Nummenmaa, A.; Makaroff, S. N.
10.1101/2024.04.04.588004 — neuroscience — Posted on 2024-04-12
2993 The Spatial Frequency Representation Predicts Category Coding in the Inferior Temporal Cortex
Toosi, R.; Karami, B.; Koushki, R.; Shakerian, F.; Noroozi, J.; Rezayat, E.; Vahabie, A.-H.; Akhaee, M. A.; Dehaqani, M.-R. A.
10.1101/2023.11.07.566068 — neuroscience — Posted on 2024-04-12
2994 IQGAP2 regulates blood-brain barrier immune dynamics
Katdare, K.; Kjar, A.; O'Brown, N.; Neal, E.; Sorets, A.; Shostak, A.; Romero Fernandez, W.; Kwiatkowski, A.; Mlouk, K.; Kim, H.; Cowell, R.; Schwensen, K.; Horner, K.; Wilson, J. T.; Schrag, M.; Megason, S.; Lippmann, E.
10.1101/2023.02.07.527394 — neuroscience — Posted on 2024-04-12
2996 STING-Activating Polymer-Drug Conjugates for Cancer Immunotherapy
Sheehy, T. L.; Kwiatkowski, A. J.; Arora, K.; Kimmel, B. R.; Schulman, J. A.; Gibson-Corley, K.; Wilson, J. T.
10.1101/2024.03.23.585817 — bioengineering — Posted on 2024-04-12
2999 Optogenetic control of Nodal signaling patterns
McNamara, H. M.; Jia, B. Z.; Guyer, A.; Parot, V. J.; Dobbs, C.; Schier, A. F.; Cohen, A. E.; Lord, N. D.
10.1101/2024.04.11.588875 — developmental biology — Posted on 2024-04-12
3000 Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.
Oorloff, M.; Hruby, A.; Averbukh, M.; Alcala, A.; Dutta, N.; Castro Torres, T.; Moaddeli, D.; Vega, M.; Kim, J.; Bong, A.; Coakley, A. J.; Hicks, D.; Wang, J.; Wang, T.; Hoang, S.; Tharp, K. M.; Garcia, G.; Sanabria, R.
10.1101/2024.04.11.589121 — cell biology — Posted on 2024-04-12
3001 Multiplexed in vivo imaging with fluorescence lifetime modulating tags
El Hajji, L.; Lam, F.; Avtodeeva, M.; Benaissa, H.; Rampon, C.; Volovitch, M.; Vriz, S.; Gautier, A.
10.1101/2024.04.12.589181 — cell biology — Posted on 2024-04-12
3002 Unexpected delayed incursion of highly pathogenic avian influenza H5N1 (clade 2.3.4.4b) in the Antarctic region
Lisovski, S.; Gunther, A.; Dewar, M.; Anley, D.; Aldunate, F.; Arce, R.; Ballard, G.; Bauer, S.; Belliure, J.; Banyard, A. C.; Boulinier, T.; Bennison, A.; Braun, C.; Cary, C.; Catry, P.; Clessin, A.; Connan, M.; Correira, E.; Cox, A.; Christina, J.; Elrod, M.; Emerit, J.; Ferreiro, I.; Fowler, Z.; Gamble, A.; Granadeiro, J. P.; Hurtado, J.; Jongsomjit, D.; Kuepfer, A.; Lesage, C.; Lejeune, M.; Lescroel, A.; Li, A.; McDonald, I. R.; Menendez-Blazquez, J.; Morandini, V.; Moratorio, G.; Militao, T.; Moreno, P.; Perbolianachis, P.; Pennycook, J.; Sander, M. M.; Schmidt, A. E.; Smyth, L.; Soutullo
10.1101/2023.10.24.563692 — microbiology — Posted on 2024-04-12
3003 Transfer of modified fecal viromes improve blood glucose regulation and alleviates symptoms of metabolic dysfunction-associated fatty liver disease in an obesity male mouse model
Mao, X.; Larsen, S. B.; Zachariassen, L. S. F.; Brunse, A.; Adamberg, S.; Castro-Mejia, J. L.; Larsen, F.; Adamberg, K.; Nielsen, D. S.; Hansen, A. K.; Hansen, C. H. F.; Rasmussen, T. S.
10.1101/2023.03.20.532903 — microbiology — Posted on 2024-04-12
3004 A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to copper stress
Leprevost, L.; Junger, S.; Lippens, G.; Guillaume, C.; Sicoli, G.; Oliveira Correia, L.; Rivera-Millot, A.; Billon, G.; Henry, C.; Antoine, R.; Dubiley, S.; Zirah, S.; Li, Y.; Jacob-Dubuisson, F.
10.1101/2024.03.18.585515 — microbiology — Posted on 2024-04-12
3006 Metabolic and imaging phenotypes associated with RB1 loss in castrate resistant prostate cancer
Ahmad, F.; White, M.; Yamamoto, K.; Crooks, D. R.; Agarwal, S.; Yang, Y.; Capaldo, B.; Raj, S.; Alilin, A. N.; Ton, A.; Adler, S.; Seidel, J.; Olkowski, C.; Cherukuri, M. K.; Choyke, P. L.; Kelly, K.; Brender, J. R.
10.1101/2023.11.15.567250 — cancer biology — Posted on 2024-04-12
3007 Evaluation of Bayesian Linear Regression Models as a Fine Mapping tool
Shrestha, M.; Bai, Z.; Gholipourshahraki, T.; Hjelholt, A. J.; Hu, S.; Kjolby, M.; Rohde, P. D.; Sorensen, P.
10.1101/2023.09.01.555889 — genomics — Posted on 2024-04-12
3009 The Lifeact-EGFP Quail: A New Avian Model for Studying Actin Dynamics In Vivo
Alvarez, Y. D.; van der Spuy, M.; Wang, J. X.; Noordstra, I.; Tan, S. Z.; Carroll, M.; Yap, A. S.; Serralbo, O.; White, M. D.
10.1101/2023.11.19.567639 — developmental biology — Posted on 2024-04-12
3012 Decoding Arbitrary and Informed Decisions from Intracranial Recordings in Humans
Marras, L.; Verwoert, M.; Ottenhoff, M. C.; Goulis, S.; van Dijk, J. P.; Tousseyn, S.; Wagner, L.; Colon, A. J.; Kubben, P. L.; Janssen, M. L.; Herff, S. A.; Herff, C.
10.1101/2023.06.01.543070 — neuroscience — Posted on 2024-04-12
3013 Cell-specialized chloroplast signaling orchestrates photosynthetic and extracellular reactive oxygen species for stress responses
Tee, E. E.; Fairweather, S. J.; Vo, H. M.; Zhao, C.; Breakspear, A.; Kimura, S.; Carmody, M.; Wrzaczek, M.; Broer, S.; Faulkner, C.; Kangasjarvi, J.; Chen, Z.-H.; Pogson, B. J.; Chan, K. X.
10.1101/2023.08.02.551742 — plant biology — Posted on 2024-04-12
3014 The lysosomal V-ATPase B1 subunit in renal proximal tubule is linked to nephropathic cystinosis
Jamalpoor, A.; van Eerde, A.; Lilien, M. R.; van Gelder, C. A.; Zaal, E. A.; Valentijn, F. A.; Broekhuizen, R.; Zielhuis, E.; Egido, J. E.; Altelaar, M.; Berkers, C. R.; Masereeuw, R.; Janssen, M. J.
10.1101/2020.07.24.219808 — pharmacology and toxicology — Posted on 2024-04-12
3015 Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona
Hozumi, A.; Totsuka, N. M.; Onodera, A.; Wang, Y.; Hamada, M.; Shiraishi, A.; Satake, H.; Horie, T.; Hotta, K.; Sasakura, Y.
10.1101/2024.04.09.588679 — developmental biology — Posted on 2024-04-11
3018 Early life stress-induced miR-708-5p affects bipolar disorder-associated phenotypes through neuronatin downregulation
Gilardi, C.; Martins, H. C.; Lo Bianco, A.; Bicker, S.; Germain, P.-L.; Gross, F.; Sungur, A. O.; Kisko, T.; Stein, F.; Meinert, S.; Woehr, M.; Schwarting, R. K.; Dannlowski, U.; Kircher, T.; Schratt, G.
10.1101/2024.03.14.584977 — neuroscience — Posted on 2024-04-11
3020 KSR1 regulates small-cell lung carcinoma tumor initiation and therapy resistance
Chatterjee, D.; Svoboda, R. A.; Huisman, D. H.; Vieira, H. M.; Rao, C.; Askew, J. W.; Fisher, K. W.; Lewis, R. E.
10.1101/2024.02.23.581815 — cancer biology — Posted on 2024-04-11
3022 Molecular interplay between HURP and Kif18A in mitotic spindle regulation
Perez-Bertoldi, J. M.; Zhao, Y.; Thawani, A.; Yildiz, A.; Nogales, E.
10.1101/2024.04.11.589088 — biophysics — Posted on 2024-04-11
3023 The impact of package selection and versioning on single-cell RNA-seq analysis
Rich, J. M.; Moses, L.; Einarsson, P. H.; Jackson, K.; Luebbert, L.; Booeshaghi, A. S.; Antonsson, S.; Sullivan, D. K.; Bray, N.; Melsted, P.; Pachter, L.
10.1101/2024.04.04.588111 — bioinformatics — Posted on 2024-04-11
3025 GRAS1 non-coding RNA protects against DNA damage and cell death by binding and stabilizing NKAP
Su, T.; Trang, N.; Zhu, J.; Kong, L.; Cheung, D.; Chou, V. W.-H.; Ellis, L.; Huang, C.; Camden, N.; McHugh, C. A.
10.1101/2023.06.20.545783 — molecular biology — Posted on 2024-04-11
3026 The landscape of antibiotic resistance genes in the nasopharynx of preterm infants: Prolonged signature of hospitalization and effects by antibiotics
Dhariwal, A.; Rajar, P.; Salvadori, G.; Amdal, H. A.; Berild, D.; Saugstad, O. D.; Fugelseth, D.; Greisen, G.; Dahle, U.; Haaland, K.; Petersen, F. C.
10.1101/2023.08.09.552435 — microbiology — Posted on 2024-04-11
3027 Evolutionary rescue of spherical mreB deletion mutants of the rod-shape bacterium Pseudomonas fluorescens SBW25
Yulo, P. R.; Desprat, N.; Gerth, M. L.; Ritzl-Rinkenberger, B.; Farr, A. D.; Liu, Y.; Zhang, X.-X.; Miller, M.; Cava, F.; Rainey, P. B.; Hendrickson, H. L.
10.1101/263681 — microbiology — Posted on 2024-04-11
3028 Arteriolar degeneration and stiffness in cerebral amyloid angiopathy are linked to β-amyloid deposition and lysyl oxidase.
Ventura-Antunes, L.; Nackenoff, A.; Romero-Fernandez, W.; Bosworth, A. M.; Prusky, A.; Wang, E.; Carvajal-Tapia, C.; Shostak, A.; Harmsen, H.; Mobley, B.; Maldonado, J.; Solopova, E.; Snider, J. C.; Merryman, W. D. D.; Lippmann, E.; Schrag, M.
10.1101/2024.03.08.583563 — neuroscience — Posted on 2024-04-11
3029 Non-canonical adrenergic neuromodulation of motoneuron intrinsic excitability through beta-receptors in wild-type and ALS mice
Antonucci, S.; Caron, G.; Dikwella, N.; Krishnamurthy, S. S.; Harster, A.; Zarrin, H.; Tahanis, A.; Olde Heuvel, F.; Danner, S. M.; Ludolph, A. C.; Grycz, K.; Baczyk, M.; Zytnicki, D.; Roselli, F.
10.1101/2024.03.25.586570 — neuroscience — Posted on 2024-04-11
3031 Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype
O'Connor, A. M.; Hagenauer, M. H.; Thew Forrester, L. C.; Maras, P. M.; Arakawa, K.; Hebda-Bauer, E. K.; Khalil, H.; Richardson, E.; Rob, F.; Sannah, Y.; Watson, S.; Akil, H.
10.1101/2023.10.03.560702 — neuroscience — Posted on 2024-04-11
3032 Dopamine Dynamics Underlying Maternal Behavioral Acquisition Facilitated by Top-down Orbitofrontal Inputs
Tasaka, G.-i.; Hagihara, M.; Irie, S.; Kobayashi, H.; Inada, K.; Kobayashi, K.; Kato, S.; Kobayashi, K.; Miyamichi, K.
10.1101/2023.02.03.527077 — neuroscience — Posted on 2024-04-11
3036 Evolution of glucuronoxylan side chain variability in vascular plants and the counter-adaptation of pathogenic cell-wall-degrading hydrolases
Yu, L.; Wilson, L. F. L.; Terrett, O. M.; Wurman-Rodrich, J.; Lyczakowski, J. J.; Yu, X.; Krogh, K. B. R. M.; Dupree, P.
10.1101/2024.01.23.575660 — plant biology — Posted on 2024-04-11
3038 The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1
Romero, R.; Chu, T.; Gonzalez-Robles, T. J.; Smith, P.; Xie, Y.; Kaur, H.; Yoder, S.; Zhao, H.; Mao, C.; Kang, W.; Pulina, M.; Lawrence, K. E.; Gopalan, A.; Zaidi, S.; Yoo, K.; Choi, J.; Fan, N.; Gerstner, O.; Karthaus, W. R.; De Stanchina, E.; Ruggles, K.; Westcott, P. M. K.; Chaligne, R.; Pe'er, D.; Sawyers, C.
10.1101/2024.04.09.588557 — cancer biology — Posted on 2024-04-11
3040 HSV-1 infection induces a downstream-shift of the +1 nucleosome
Weiss, E.; Whisnant, A. W.; Hennig, T.; Djakovic, L.; Doelken, L.; Friedel, C. C.
10.1101/2024.03.06.583707 — bioinformatics — Posted on 2024-04-11
3041 Adaptive Digital Tissue Deconvolution
Görtler, F.; Mensching-Buhr, M.; Skaar, O.; Schrod, S.; Sterr, T.; Schäfer, A.; Beissbarth, T.; Joshi, A.; Zacharias, H. U.; Grellscheid, S. N.; Altenbuchinger, M.
10.1101/2023.02.08.527583 — bioinformatics — Posted on 2024-04-11
3043 Ancestral versus Modern Substrate Scope in Family-1 Glycosidases
Gutierrez-Rus, L. I.; Petrovic, D.; Schneider, P.; Zorn, K.; Gamiz-Arco, G.; De Maria, L.; Falcioni, F.; Risso, V. A.; Hayes, M. A.; Sanchez-Ruiz, J. M.
10.1101/2024.04.11.589065 — biochemistry — Posted on 2024-04-11
3045 A map of the rubisco biochemical landscape
Prywes, N.; Phillips, N. R.; Oltrogge, L. M.; Lindner, S.; Tsai, Y.-C.; de Pins, B.; Cowan, A. E.; Taylor-Kearney, L. J.; Chang, H. A.; Hall, L. N.; Bellieny-Rabelo, D.; Nisonoff, H. M.; Weissman, R. F.; Flamholz, A. I.; Ding, D.; Bhatt, A.; Shih, P.; Mueller-Cajar, O.; Milo, R.; Savage, D. F.
10.1101/2023.09.27.559826 — biochemistry — Posted on 2024-04-11
3047 Probing enzyme-dependent pseudouridylation using direct RNA sequencing to assess neuronal epitranscriptome plasticity
Fanari, O.; Tavakoli, S.; Akeson, S.; Makhamreh, A.; Nian, K.; McCormick, C. A.; Qiu, Y.; Bloch, D.; Jain, M.; Wanunu, M.; Rouhanifard, S. H.
10.1101/2024.03.26.586895 — genomics — Posted on 2024-04-11
3052 Olfaction in Tephritidae: a balance between detection and discrimination
Ramiaranjatovo, G.; Charlery de la Masseliere, M.; Dekker, T.; Duyck, P.-F.; Larsson Herrera, S.; Reynaud, B.; Jacob, V.
10.1101/2024.03.14.584788 — ecology — Posted on 2024-04-11
3053 Characterising a stable five-species microbial community for use in experimental evolution and ecology.
Castledine, M.; Pennycook, J.; Newbury, A.; Lear, L.; Erdos, Z.; Lewis, R.; Kay, S.; Sanders, D.; Sunderhauf, D.; Buckling, A.; Hesse, E.; Padfield, D.
10.1101/2020.04.24.059097 — ecology — Posted on 2024-04-11
3055 Targeted DamID detects cell-type specific histone modifications in vivo
van den Ameele, J.; Trauner, M.; Hörmanseder, E.; Donovan, A. P. A.; Llora Batlle, O.; Cheetham, S.; Krautz, R.; Yakob, R.; Gurdon, J. B.; Brand, A. H.
10.1101/2024.04.11.589050 — molecular biology — Posted on 2024-04-11
3056 Harnessing RNA-based DNA repair pathways for targeted gene editing
Huynh, N.; Kwon, S.; McMurrough, T. A.; Loedige, K. W.; Tavassoli, M.; Shao, W.; Qin, H.; Luu, K.; Dharni, B.; Haydaychuk, O.; Stead, B. E.; Edgell, D.
10.1101/2024.04.09.588775 — molecular biology — Posted on 2024-04-11
3057 In vivo Assembly of Bacterial Partition Condensates on Supercoiled and Linear DNA
Sekkouri Alaoui, H.; Quebre, V.; Delimi, L.; Rech, J.; Debaugny-Diaz, R.; Labourdette, D.; Campos, M.; Cornet, F.; Walter, J.-C.; Bouet, J.-Y.
10.1101/2024.03.26.585537 — molecular biology — Posted on 2024-04-11
3058 Single-cell imaging of the lytic phage life cycle dissects the timing and noise in individual infection steps
Wedd, C.; Yunusov, T.; Smith, A.; Li, R.; Hardo, G.; Hunter, M.; Majed, R.; Fusco, D.; Bakshi, S.
10.1101/2024.04.11.588870 — microbiology — Posted on 2024-04-11
3060 Genomic surveillance reveals that the dengue 2 virus lineage responsible for the 2023-2024 epidemic in the French Caribbean Islands is resistant to Mosnodenvir
Bouzidi, H. S.; Sen, S.; Piorkowski, G.; Pezzi, L.; Ayhan, N.; Fontaine, A.; Canivez, T.; Geulen, M.; Amaral, R.; Grard, G.; Durand, G. A.; de Lamballerie, X.; Touret, F.; Klitting, R.
10.1101/2024.04.10.588695 — microbiology — Posted on 2024-04-11
3064 Investigating working memory updating processes of the human subcortex using 7T MRI
Trutti, A. C.; Sjoerds, Z.; Boag, R. J.; Walstra, S. L.; Miletic, S.; Isherwood, S. J.; Bazin, P.-L.; Hommel, B.; Habli, S.; Tse, D.; Haberg, A. K.; Forstmann, B. U.
10.1101/2024.03.14.584970 — neuroscience — Posted on 2024-04-11
3066 Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4
Daumke, O.; Mohd, S.; Oder, A.; Specker, E.; Neuenschwander, M.; von Kries, J. P.
10.1101/2024.04.11.589129 — biochemistry — Posted on 2024-04-11
3069 Chromosomal-level genome assembly and single-nucleotide polymorphism sites of black-faced spoonbill Platalea minor
Hong Kong Biodiversity Genomics Consortium, ; Hui, J. H. L.; Chan, T.-F.; Chan, L.; Cheung, S. G.; Cheang, C. C.; Fang, J.; Gaitan-Espitia, J. D.; Lau, S.; Sung, Y. H.; Wong, C.; Yip, K.; Wei, Y.; So, W. L.; Nong, W.; law, s.; Rose-Jeffreys, L.; Crow, P.; Leong, A.; Yip, H.
10.1101/2024.04.08.588650 — genomics — Posted on 2024-04-11
3070 Resistance and resilience of soil microbiomes under climate change
Boyle, J. A.; Murphy, B. K.; Ensminger, I.; Stinchcombe, J. R.; Frederickson, M. E.
10.1101/2023.08.04.551981 — ecology — Posted on 2024-04-11
3072 Molecular Xenomonitoring (MX) allows real-time surveillance of West Nile and Usutu virus in mosquito populations.
Bigeard, C.; Pezzi, L.; Klitting, R.; Ayhan, N.; L'Ambert, G.; Gomez, N.; Piorkowski, G.; Amaral, R.; Durand, G.; Ramiara, K.; Camille, M.; Grard, G.; Touzet, T.; Zientara, S.; Charrel, R.; Gonzalez, G.; Duvignaud, A.; Malvy, D.; de Lamballerie, X.; Fontaine, A.
10.1101/2024.04.10.588707 — molecular biology — Posted on 2024-04-11
3073 The transcription factor Sfp1 imprints specific classes of mRNAs and links their synthesis to cytoplasmic decay
Kelbert,, M.; Jordan-Pla, A.; de-Miguel-Jimenez, L.; Garcia-Martinez, J.; Selitrennik, M.; Guterman,, A.; Henig,, N.; Granneman,, S.; Perez-Ortin, J. E.; Chavez, S.; Choder, M.
10.1101/2023.09.13.557510 — molecular biology — Posted on 2024-04-11
3074 Inhibition of Cyp1a Protects Mice against Anthracycline Cardiomyopathy
Liu, J.; Curtin, C.; Lall, R.; Lane, S.; Wieke, J.; Ariza, A.; Sejour, L.; Vlachos, I.; Zordoky, B.; Peterson, R.; Asnani, A.
10.1101/2024.04.10.588915 — molecular biology — Posted on 2024-04-11
3077 Expanding the cultivated human archaeome by targeted isolation of novel Methanobrevibacter strains from fecal samples
Duller, S.; Vrbancic, S.; Szydlowski, L.; Mahnert, A.; Blohs, M.; Predl, M.; Kumpitsch, C.; Zrim, V.; Hoegenauer, C.; Kosciolek, T.; Schmitz, R. A.; Eberhard, A.; Dragovan, M.; Schmidberger, L.; Zurabischvili, T.; Weinberger, V.; Moser, A. M.; Kolb, D.; Pernitsch, D.; Mohammadzadeh, R.; Kuehnast, T.; Rattei, T.; Moissl-Eichinger, C.
10.1101/2024.04.10.588852 — microbiology — Posted on 2024-04-11
3078 AcuM and AcuK: the global regulators controlling multiple cellular metabolisms in a dimorphic fungus Talaromyces marneffei
Wangsanut, T.; Amsri, A.; Kalawil, T.; Sukantamala, P.; Jeenkeawpieam, J.; Andrianopoulos, A.; Pongpom, M.
10.1101/2024.04.10.588979 — microbiology — Posted on 2024-04-11
3079 The intracellular bacterium Orientia tsutsugamushi hijacks the adaptor protein BICD2 for dynein-based motility
Manigrasso, G.; Saharat, K.; Kullapanich, C.; Boulanger, J.; Morgan, T. E.; Kramer, H.; Salje, J.; Carter, A. P.
10.1101/2024.04.11.589026 — microbiology — Posted on 2024-04-11
3080 Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages
Schami, A.; Islam, M. N.; Wall, M.; Hicks, A.; Meredith, R.; Kreiswirth, B.; Mathema, B.; Belisle, J. T.; Torrelles, J. B.
10.1101/2024.04.10.588986 — microbiology — Posted on 2024-04-11
3082 Archaeal type six secretion system mediates contact-dependent antagonism
Zachs, T.; Malit, J. J. L.; Xu, J.; Schürch, A.; Sivabalasarma, S.; Nussbaum, P.; Albers, S.-V.; Pilhofer, M.
10.1101/2024.04.11.588991 — microbiology — Posted on 2024-04-11
3083 Impact of redox fluctuations on the spatial distribution of the microbial community in a forest soil: A lysimeter experiment
Wang, S.; Miele, F.; Benettin, P.; Asadollahi, M.; Pasqualini, J.; Frutschi, M.; Rossi, P.; Jacquemin, N.; Rinaldo, A.; Bernier-Latmani, R.
10.1101/2024.04.11.588997 — microbiology — Posted on 2024-04-11
3084 MEA-NAP compares microscale functional connectivity, topology, and network dynamics in organoid or monolayer neuronal cultures
Sit, T. P.; Feord, R. C.; Dunn, A. W.; Chabros, J.; Oluigbo, D.; Smith, H. H.; Burn, L.; Chang, E.; Boschi, A.; Yuan, Y.; Gibbons, G. M.; Khayat-Khoei, M.; De Angelis, F.; Hemberg, E.; Hemberg, M.; Lancaster, M. A.; Lakatos, A.; Eglen, S. J.; Paulsen, O.; Mierau, S. B.
10.1101/2024.02.05.578738 — neuroscience — Posted on 2024-04-11
3086 Cognitive control of behavior and hippocampal information processing without medial prefrontal cortex
Park, E.; Reilly, K. O.; Grubbs, G.; Taborga, D.; Nicholas, K.; Ahmeda, A. S.; Ruiz, N.; Kim, N.; Segura-Carrillo, S.; Fenton, A. A.
10.1101/2019.12.20.884262 — neuroscience — Posted on 2024-04-11
3087 Connectome-Based Attractor Dynamics Underlie Brain Activity in Rest, Task, and Disease
Englert, R.; Kincses, B.; Kotikalapudi, R.; Gallitto, G.; Li, J.; Hoffschlag, K.; Woo, C.-W.; Wager, T.; Timmann, D.; Bingel, U.; Spisak, T.
10.1101/2023.11.03.565516 — neuroscience — Posted on 2024-04-11
3089 MRAP2 modifies signaling and oligomerization state of the melanocortin-4 receptor
Sohail, I.; Laurin, S.-A.; Kleinau, G.; Chunilal, V.; Kagiali, Z. C. U.; Lohse, M. J.; Scheerer, P.; Bouvier, M.; McCormick, P.; Annibale, P.; Biebermann, H.
10.1101/2024.04.09.588099 — pharmacology and toxicology — Posted on 2024-04-11
3090 Stress granule dysfunction via chromophore-associated light inactivation
Koizumi, T.; Fujimoto, A.; Kawaguchi, H.; Kurosaki, T.; Kitamura, A.
10.1101/2023.08.12.553066 — biophysics — Posted on 2024-04-11
3092 Quantification of histone H1 subtypes using targeted proteomics.
Lopez-Gomez, J.; Villareal, L.; Andres, M.; Ponte, I.; Xicoy, B.; Zamora, L.; Vilaseca, M.; Roque, A.
10.1101/2024.01.20.576464 — biochemistry — Posted on 2024-04-11
3093 Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates
Wells, J. N.; Leber, V.; Edwardes, L. V.; Allyjaun, S.; Peach, M.; Tomkins, J.; Kefala-Stavridi, A.; Faull, S. V.; Aramayo, R.; Pestana, C. M.; Ranjha, L.; Speck, C.
10.1101/2024.04.11.589023 — biochemistry — Posted on 2024-04-11
3095 SCC3 is an axial element essential for homologous chromosome pairing and synapsis
Zhao, Y.; Ren, L.; Zhao, T.; You, H.; Miao, Y.; Liu, H.; Cao, L.; Wang, B.; Shen, Y.; Li, Y.; Tang, D.; Cheng, Z.
10.1101/2023.11.22.568373 — genetics — Posted on 2024-04-11
3101 Coatomer complex I is required for the transport of SARS-CoV-2 progeny virions from the endoplasmic reticulum-Golgi intermediate compartment
Hirbayashi, A.; Muramoto, Y.; Takenaga, T.; Tsunoda, Y.; Wakazaki, M.; Sato, M.; Fujita-Fujiharu, Y.; Nomura, N.; Yamauchi, K.; Onishi, C.; Nakano, M.; Toyooka, K.; Noda, T.
10.1101/2024.04.10.588984 — microbiology — Posted on 2024-04-11
3102 The energy metabolism of Cupriavidus necator in different trophic conditions
Jahn, M.; Crang, N.; Gynna, A. H.; Kabova, D.; Frielingsdorf, S.; Lenz, O.; Charpentier, E.; Hudson, E. P.
10.1101/2024.02.26.582058 — microbiology — Posted on 2024-04-11
3106 Microgliosis, astrogliosis and loss of aquaporin-4 polarity in frontal cortex of COVID-19 patients
Beiersdorfer, A.; Rotermund, N.; Schulz, K.; Busch, M.; Hirnet, D.; Henne, S.; Schwarzenberg, F.; Dottermusch, M.; Ondruschka, B.; Matschke, J.; Wuelfing, C.; Glatzel, M.; Lohr, C.
10.1101/2024.04.10.588851 — neuroscience — Posted on 2024-04-11
3108 The control costs of human brain dynamics
Ceballos, E. G.; Luppi, A. I.; Castrillon, G.; Saggar, M.; Misic, B.; Riedl, V.
10.1101/2024.01.24.577068 — neuroscience — Posted on 2024-04-11
3109 Silybin A from Silybum marianum reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids
Koeberle, S. C.; Thuermer, M.; Werner, M.; Grander, J.; Hofer, L.; Gollowitzer, A.; Su, F.; Le Xuan, L.; Benscheid, F. J.; Bonyadi Rad, E.; Zarrelli, A.; Di Fabio, G.; Werz, O.; Romanucci, V.; Lupp, A.; Koeberle, A.
10.1101/2024.04.09.588052 — pharmacology and toxicology — Posted on 2024-04-11
3110 Hierarchical determinants of the oxidation-induced mutational landscape in human cells.
Cordero, C.; Mehta, K. P. M.; Weaver, T. M.; Ling, J. A.; Freudenthal, B. D.; Cortez, D.; Roberts, S. A.
10.1101/2024.04.08.588428 — cancer biology — Posted on 2024-04-11
3111 A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation
Laughlin, P. M.; Young, K.; Wang, J. C.-Y.; Gonzalez-Gutierrez, G.; Zlotnick, A.
10.1101/2024.04.10.588883 — biochemistry — Posted on 2024-04-11
3112 A microbial derived bile acid acts as GPBAR1 agonist and RORγt inverse agonist and reverses inflammation in inflammatory bowel disease
Biagioli, M.; Di Giorgio, C.; Massa, C.; Marchiano', S.; Bellini, R.; Bordoni, M.; Urbani, G.; Roselli, R.; Lachi, G.; Morretta, E.; Dal Piaz, F.; Charlier, B.; Fiorillo, B.; Catalanotti, B.; Cari, L.; Nocentini, G.; Ricci, P.; Distrutti, E.; Sepe, V.; Zampella, A.; Monti, M. C.; Fiorucci, S.
10.1101/2024.04.08.588556 — immunology — Posted on 2024-04-11
3115 Abnormal morphology and synaptogenic signaling in astrocytes following prenatal opioid exposure
Niebergall, E. B.; Weekley, D.; Mazur, A.; Olszewski, N. A.; DeSchepper, K. M.; Radant, N.; Vijay, A. S.; Risher, C.
10.1101/2024.04.08.588580 — neuroscience — Posted on 2024-04-11
3117 Defective Homologous Recombination and Genomic Instability Predict Increased Responsiveness to Carbon Ion Radiotherapy in Pancreatic Cancer
Sishc, B. J.; Saha, J.; Polsdofer, E.; Ding, L.; Lu, H.; Wang, S.-Y.; Swancutt, K. L.; Nicholson, J. H.; Facoetti, A.; Pompos, A.; Ciocca, M.; Aguilera, T. A.; Story, M. D.; Davis, A. J.
10.1101/2024.04.08.588534 — cancer biology — Posted on 2024-04-11
3119 Pannexin 1 and Pannexin 3 differentially regulate the tumorigenic properties of cutaneous squamous cell carcinoma
O'Donnell, B. L.; Johnston, D.; Bhatt, A.; Kardan, Z.; Stefan, D.; Bysice, A.; Sayedyahossein, S.; Dagnino, L.; Cecchini, M.; Loganathan, S. K.; Roth, K.; Penuela, S.
10.1101/2024.04.08.588550 — cancer biology — Posted on 2024-04-11
3121 Nor-LAAM loaded PLGA Microparticles for Treating Opioid Use Disorder
Ingabire, D.; Qin, C.; Meng, T.; Raynold, A. A. M.; Sudarjat, H.; Townsend, E. A.; Pangeni, R.; Poudel, S.; Arriaga, M.; Zhao, L.; Chow, W. N.; Banks, M. A.; Xu, Q.
10.1101/2024.04.08.588574 — bioengineering — Posted on 2024-04-11
3122 Remote sensing for estimating genetic parameters of biomass accumulation and modeling stability of growth curves in alfalfa
Thapa, R.; Kunze, K.; Hansen, J.; Pierce, C.; Moore, V.; Ray, I.; Wickes-Do, L.; Morales, N.; Sabadin, F.; Santantonio, N.; Gore, M. A.; Robbins, K. R.
10.1101/2024.04.08.588572 — genetics — Posted on 2024-04-11
3125 Paradigms of convergent evolution in enzymes
Riziotis, I. G.; Kafas, J. C.; Ong, G.; Borkakoti, N.; Ribeiro, A. J. M.; Thornton, J.
10.1101/2024.04.08.588552 — evolutionary biology — Posted on 2024-04-11
3128 DNA aptamers that modulate biological activity of model neurons
Rolli, J.; Pearson, K.; Wilbanks, B.; Hrstka, S.; Warrington, A.; Staff, N.; Maher, L. J.
10.1101/2024.04.08.588576 — neuroscience — Posted on 2024-04-11
3129 Microstructural Brain Correlates of Inter-individual Differences in Respiratory Interoception
Nikolova, N. E.; Fischer Ehmsen, J.; Banellis, L.; Braendholt, M.; Vejloe, M.; Fardo, F.; Allen, M.
10.1101/2024.04.08.588519 — neuroscience — Posted on 2024-04-11
3131 Bioisosteric analogs of MDMA with improved pharmacological profile
Alberto-Silva, A. S.; Hemmer, S.; Bock, H. A.; Alves da Silva, L.; Scott, K. R.; Kastner, N.; Bhatt, M.; Niello, M.; Jantsch, K.; Kudlacek, O.; Bossi, E.; Stockner, T.; Meyer, M. R.; McCorvy, J. D.; Brandt, S. D.; Kavanagh, P. V.; Sitte, H. H.
10.1101/2024.04.08.588083 — pharmacology and toxicology — Posted on 2024-04-11
3137 Profiling the intestinal microbiota, plasma bile acids and inflammation markers reveals novel associations in Crohn's disease and Ulcerative colitis.
Prast-Nielsen, S.; Granstrom, A.; Kiasat, A.; Ahlstrom, G.; Edfeldt, G.; Rautiainen, S.; Boulund, F.; Andersson, F. O.; Lindberg, J.; Schuppe-Koistinen, I.; Gustafsson, U. O.; Engstrand, L.
10.1101/2024.04.08.588526 — bioinformatics — Posted on 2024-04-11
3139 A single cell atlas of the mouse seminal vesicle
Sun, F.; Desevin, K.; Fu, Y.; Parameswaran, S.; Mayall, J.; Rinaldi, V.; Krietenstein, N.; Manukyan, A.; Yin, Q.; Galan, C.; Yang, C.-H.; Shindyapina, A.; Gladyshev, V. N.; Garber, M.; Schjenken, J. E.; Rando, O.
10.1101/2024.04.08.588538 — genomics — Posted on 2024-04-11
3140 Somatic embryogenesis of grapevine (Vitis vinifera) expresses a transcriptomic hourglass
Koska, S.; Leljak-Levanic, D.; Malenica, N.; Bigovic Villi, K.; Futo, M.; Corak, N.; Jagic, M.; Tusar, A.; Kasalo, N.; Domazet-Loso, M.; Vlahovicek, K.; Domazet-Loso, T.
10.1101/2024.04.08.588272 — evolutionary biology — Posted on 2024-04-11
3141 Adaptive evolution of sesquiterpene deoxyphomenone in mycoparasitism by Hansfordia pulvinata associated with horizontal gene transfer from Aspergillus species
Maeda, K.; Sumita, T.; Nishi, O.; Sushida, H.; Higashi, Y.; Nakagawa, H.; Suzuki, T.; Iwao, E.; Fanani, M. Z.; Nishiya, Y.; Iida, Y.
10.1101/2024.03.22.586281 — microbiology — Posted on 2024-04-11
3145 A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons
Kelly, D.; Bicker, S.; Winterer, J.; Nanda, P.; Germain, P.-L.; Dieterich, C.; Schratt, G.
10.1101/2024.04.09.588686 — neuroscience — Posted on 2024-04-11
3149 The uptake of small extracellular vesicles by recipient cells is facilitated by paracrine adhesion signaling
Hirosawa, K. M.; Sato, Y.; Kasai, R. S.; Yamaguchi, E.; Komura, N.; Ando, H.; Hoshino, A.; Yokota, Y.; Suzuki, K. G. N.
10.1101/2024.04.11.589012 — cell biology — Posted on 2024-04-11
3150 Interplay of geometry and mechanics in epithelial wound healing
Babu, N. K.; Sreepadmanabh, M.; Dutta, S.; Bhattacharjee, T.
10.1101/2024.04.08.588496 — biophysics — Posted on 2024-04-11
3151 How fast are viruses spreading in the wild?
Dellicour, S.; Bastide, P.; Rocu, P.; Fargette, D.; Hardy, O. J.; Suchard, M. A.; Guindon, S.; Lemey, P.
10.1101/2024.04.10.588821 — evolutionary biology — Posted on 2024-04-11
3153 Extracellular vesicles adhere to cells predominantly through the interaction of CD151-associated integrin heterodimers and GM1 with laminin
Isogai, T.; Hirosawa, K. M.; Kanno, M.; Sho, A.; Kasai, R. S.; Komura, N.; Ando, H.; Furukawa, K.; Ohmi, Y.; Furukawa, K.; Yokota, Y.; Suzuki, K. G. N.
10.1101/2024.04.11.589011 — cell biology — Posted on 2024-04-11
3156 A promiscuous mechanism to phase separate eukaryotic carbon fixation in the green lineage
Barrett, J.; Naduthodi, M. I. S.; Mao, Y.; Degut, C.; Musial, S.; Salter, A.; Leake, M. C.; Plevin, M. J.; McCormick, A. J.; Blaza, J. N.; Mackinder, L.
10.1101/2024.04.09.588658 — plant biology — Posted on 2024-04-11
3157 Genome editing in almond: A CRISPR-based approach through hairy root transformation
Jedlickova, V.; Stefkova, M.; Sanchez Lopez, J. F.; Grimplet, J.; Rubio Cabetas, M. J.; Robert, H. S.
10.1101/2024.04.11.588989 — plant biology — Posted on 2024-04-11
3161 Efficient Gene Editing and Overexpression of Gametophyte Transformation in a Model Fern
Jiang, W.; Deng, F.; Babla, M.; Chen, C.; Yang, D.; Tong, T.; Qin, Y.; Chen, G.; Marchant, B.; Soltis, P. S.; Soltis, D.; Zeng, F.; Chen, Z.
10.1101/2024.04.10.588889 — plant biology — Posted on 2024-04-11
3162 Centromeric localization of KNL2 and CENP-C proteins in plants depends on their centromere-targeting domain and DNA-binding regions
Yalagapati, S. P.; Ahmadli, U.; Sinha, A.; Kalidass, M.; Dabravolski, S.; Zuo, S.; Yadala, R.; Rutten, T.; Talbert, P.; Lermontova, I.
10.1101/2024.04.11.588992 — plant biology — Posted on 2024-04-11
3163 The Class III peroxidase OsPrx20 is a key regulator of stress response and growth in rice
Shen, T.; Qingwen, W.; Chen, D.; Ju, H.; Yan, R.; Xu, F.; Fu, D.; Bu, X.; Zhang, H.; Hu, J.; Zhang, Z.; Ni, L.; Jiang, M.
10.1101/2024.04.08.588571 — plant biology — Posted on 2024-04-11
3165 Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis
Ishka, M. R.; Sussman, H.; Hu, Y.; Alqahtani, M. D.; Craft, E.; Sicat, R.; Wang, M.; Yu, L.; AitHaddou, R.; Li, B.; Drakakaki, G.; Nelson, A.; Pineros, M.; Korte, A.; Jaremko, L.; Testerink, C.; Tester, M.; Julkowska, M. M.
10.1101/2024.04.09.588564 — plant biology — Posted on 2024-04-11
3166 Callose Deficiency Modulates Plasmodesmata frequency and the intercellular space In Rice Anthers
Somashekar, H.; Takanami, K.; Benitez-Alfonso, Y.; Oishi, A.; Hiratsuka, R.; Nonomura, K.-I.
10.1101/2024.04.08.588242 — plant biology — Posted on 2024-04-11
3168 Self-incompatibility phenotypes of SRK mutants can be predicted with high accuracy
Yamamoto, M.; Ohtake, S.; Shinosawa, A.; Shirota, M.; Mitsui, Y.; Kitashiba, H.
10.1101/2024.04.10.588956 — plant biology — Posted on 2024-04-11
3171 Regional Variations in Live Proportions of Southwest Pacific Cold-Water Coral Solenosmilia variabilis Reefs
Barnhill, K. A.; Chin, C.; Tracey, D.; Clark, M.; De Clippele, L.; Henley, S. F.; Wolfram, U.; Hennige, S.
10.1101/2024.04.08.588521 — ecology — Posted on 2024-04-11
3172 In vivo evaluation of thermally drawn biodegradable optical fibers as brain neural interfaces
Abdollahian, P.; Sui, K.; Li, G.; Wang, J.; Zhang, C.; Wang, Y.; Berg, R. W.; Meneghetti, M.; Markos, C.
10.1101/2024.04.08.588517 — bioengineering — Posted on 2024-04-11
3173 Population genomics reveals demographic history and climate adaptation in Japanese Arabidopsis halleri
Suda, R. A.; Kubota, S.; Kumar, V.; Castric, V.; Kraemer, U.; Morinaga, S.-I.; Tsuchimatsu, T.
10.1101/2024.04.08.588504 — evolutionary biology — Posted on 2024-04-11
3174 Deciphering hepatitis B virus phospho-signature in primary human hepatocytes
Pastor, F.; Charles, E.; Belmudes, L.; Chabrolles, H.; Cescato, M.; Rivoire, M.; Burger, T.; Passot, G.; Durantel, D.; Lucifora, J.; Coute, Y.; SALVETTI, A.
10.1101/2024.04.10.588822 — microbiology — Posted on 2024-04-11
3176 Deciphering neuronal variability across states reveals dynamic sensory encoding
Akella, S.; Ledochowitsch, P.; Siegle, J. H.; Belski, H.; Denman, D. J.; Buice, M. A.; Durand, S.; Koch, C.; Olsen, S. R.; Jia, X.
10.1101/2024.04.03.587408 — neuroscience — Posted on 2024-04-11
3178 Hybracter: Enabling Scalable, Automated, Complete and Accurate Bacterial Genome Assemblies
Bouras, G.; Houtak, G.; Wick, R. R.; Mallawaarachchi, V.; Roach, M. J.; Papudeshi, B.; Judd, L. M.; Sheppard, A. E.; Edwards, R. A.; Vreugde, S.
10.1101/2023.12.12.571215 — bioinformatics — Posted on 2024-04-11
3180 Sox9 marks limbal stem cells and is required for asymmetric cell fate switch in the corneal epithelium
Rice, G.; Farrelly, O.; Huang, S.; Kuri, P.; Curtis, E.; Ohman, L.; Li, N.; Lengner, C.; Lee, V.; Rompolas, P.
10.1101/2024.04.08.588195 — developmental biology — Posted on 2024-04-11
3183 Inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet.
Lee, Y.; Sarkar, A.; Tassey, J.; Levi, J. N.; Lee, S.; Liu, N. Q.; Drake, A. C.; Magallanes, J.; Lu, J.; Ge, D.; Tang, H.; Mkaratigwa, T.; Bian, F.; Shkhyan, R.; Bonaguidi, M. A.; Evseenko, D.
10.1101/2024.04.08.588362 — cell biology — Posted on 2024-04-11
3184 Efficient Generation of Human Pluripotent Stem Cells from Frozen Cord Tissue via Chemical Reprogramming
Liu, C.; Nansubuga, C.; Mahnke, D. K.; Li, S.; Minx, J.; Miller, B.; Shen, M.; Beyer, A.; Han, L.; Lincoln, J.
10.1101/2024.04.10.588154 — cell biology — Posted on 2024-04-11
3185 Lgr5+ intestinal stem cells are required for organoid survival after genotoxic injury
Lee, J.; Gleizes, A.; Takaesu, F.; Hailstock, T.; Webster, S. F.; Gracz, A. D.
10.1101/2024.04.08.588400 — cell biology — Posted on 2024-04-11
3186 The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1
Romero, R.; Chu, T.; Gonzalez-Robles, T. J.; Smith, P.; Xie, Y.; Kaur, H.; Yoder, S.; Zhao, H.; Mao, C.; Kang, W.; Pulina, M.; Lawrence, K. E.; Gopalan, A.; Zaidi, S.; Yoo, K.; Choi, J.; Fan, N.; Gerstner, O.; Karthaus, W. R.; De Stanchina, E.; Ruggles, K.; Westcott, P. M. K.; Chaligne, R.; Pe'er, D. D.; Sawyers, C.
10.1101/2024.04.09.588557 — cell biology — Posted on 2024-04-11
3187 Mechanical confinement induces ferroptosis through mitochondrial dysfunction
Zhou, F.; Ju, R. J.; Kang, C.; Li, J.; Yang, A.; Libert, A.; Sun, Y.; Liang, L.; Hu, X.; Stehbens, S. J.; Wu, C.
10.1101/2024.02.23.581510 — cell biology — Posted on 2024-04-11
3188 Humanized in vivo bone marrow models orchestrate multi-lineage human hematopoietic cell development
Renou, L.; SUN, W.; Friedrich, C.; Galant, K.; Conrad, C.; Plantier, E.; Schallmoser, K.; Kritsch, L.; Barroca, V.; Devanand, S.; Dechamps, N.; Reinisch, A.; Martinovic, J.; Magnani, A.; Faivre, L.; Calvo, J.; Perie, L.; Kosmider, O.; Pflumio, F.
10.1101/2024.04.08.588553 — cell biology — Posted on 2024-04-11
3192 A human-specific enhancer fine-tunes radial glia potency and corticogenesis
Liu, J.; Mosti, F.; Zhao, H.; Sotelo-Fonseca, J.; Escobar-Tomlienovich, C.; Lollis, D.; Manso Musso, C.; Mao, Y.; Massri, A.; Doll, H.; Sousa, A.; Wray, G. A.; Schmidt, E.; Silver, D.
10.1101/2024.04.10.588953 — neuroscience — Posted on 2024-04-11
3194 Multi-omic QTL mapping in early developmental tissues reveals phenotypic and temporal complexity of regulatory variants underlying GWAS loci
Arthur, T. D.; Nguyen, J. P.; D'Antonio-Chronowska, A.; Jaureguy, J.; Silva, N.; Henson, B.; iPSCORE Consortium, ; Panopoulos, A. D.; Belmonte, J. C. I.; D'Antonio, M.; McVicker, G.; Frazer, K. A.
10.1101/2024.04.10.588874 — genomics — Posted on 2024-04-11
3195 Heterozygous Eif4nif1 Stop Gain Mice Replicate the Primary Ovarian Insufficiency Phenotype in Women
Moriwaki, M.; Liu, L.; James, E.; Tolley, N.; O'Connor, A.; Emery, B.; Aston, K.; Campbell, R.; Welt, C.
10.1101/2024.04.09.588694 — developmental biology — Posted on 2024-04-11
3198 Characterization of liver-pancreas crosstalk following beta-cell loss reveals a role for the molybdenum cofactor in beta-cell regeneration
Karampelias, C.; Baloiu, B.; Rathkolb, B.; da Silva-Buttkus, P.; Bachar-Wikstrom, E.; Marschall, S.; Fuchs, H.; Gailus-Durner, V.; Chu, L.; Hrabe de Angelis, M.; Andersson, O.
10.1101/2024.04.09.588677 — developmental biology — Posted on 2024-04-11
3204 Glia-derived secretory fatty acid binding protein Obp44a regulates lipid storage and efflux in the developing Drosophila brain
Yin, J.; Chen, H.-l.; Grigsby-Brown, A.; He, Y.; Cotten, M. L.; Short, J.; Dermady, A.; Lei, J.; Gibbs, M.; Cheng, E. S.; Zhang, D.; Long, C.; Xu, L.; Zhong, T.; Abzalimov, R.; Haider, M.; Sun, R.; Zhou, Q.; Tjandra, N.; Yuan, Q.
10.1101/2024.04.10.588417 — developmental biology — Posted on 2024-04-11
3205 Activity-dependent COX-2 proteolysis generates a catalytically inactive fragment that affects aerobic respiration
Hartal-Benishay, L. H.; Tal, S.; Abd Elkader, A.; Ehsainieh, O.; Sroji-Eid, R.; Mikl, M.; Barki-Harrington, L.
10.1101/2024.04.08.588559 — cell biology — Posted on 2024-04-11
3206 Plasma membrane and cytoplasmic compartmentalization: a dynamic structural framework required for pollen tube tip growth
Fritz, C.; Reimann, T. M.; Adler, J.; Knab, J.; Schulmeister, S.; Kriechbaum, C.; Mueller, S.; Parmryd, I.; Kost, B.
10.1101/2024.04.08.588543 — cell biology — Posted on 2024-04-11
3208 Ribosome-binding protein 1, RRBP1, maintains peroxisomal biogenesis
Fatima, K.; Vihinen, H.; Akpinar, B. A.; Somborac, T.; Jokitalo, E.; Katajisto, P.; Konovalova, S.
10.1101/2024.04.10.588905 — cell biology — Posted on 2024-04-11
3212 Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden
Weigl, M.; Krammer, T. L.; Pultar, M.; Wieser, M.; Chaib, S.; Suda, M.; Diendorfer, A.; Khamina-Kotisch, K.; Giorgadze, N.; Pirtskhalava, T.; Johnson, K. O.; Inman, C. L.; Ailing, X.; Laemmermann, I.; Meixner, B.; Wang, L.; Xu, M.; Grillari, R.; Ogrodnik, M. B.; Tchkonia, T.; Hackl, M.; Kirkland, J. L.; Grillari, J.
10.1101/2024.04.10.588794 — molecular biology — Posted on 2024-04-10
3213 Reward Circuit Local Field Potential Modulations Precede Risk Taking
Hughes, N. C.; Qian, H.; Zargari, M.; Zhao, Z.; Singh, B.; Wang, Z.; Fulton, J. N.; Johnson, G. W.; Li, R.; Dawant, B. M.; Englot, D. J.; Constantinidis, C.; Roberson, S. T. W.; Bick, S. K.
10.1101/2024.04.10.588629 — neuroscience — Posted on 2024-04-11
3214 Spatiotemporal cerebral blood flow dynamics underlies emergence of the limbic-sensorimotor-association cortical gradient in human infancy
Ouyang, M.; Detre, J. A.; Hyland, J. L.; Sindabizera, K. L.; Kuschner, E. S.; Edgar, J. C.; Peng, Y.; Huang, H.
10.1101/2024.04.10.588784 — neuroscience — Posted on 2024-04-11
3216 Regulatory variation controlling architectural pleiotropy in maize
Bertolini, E.; Rice, B. R.; Braud, M.; Yang, J.; Hake, S.; Strable, J.; Lipka, A. E.; Eveland, A. L.
10.1101/2023.08.19.553731 — plant biology — Posted on 2024-04-10
3217 Absolute calibration of ribosome profiling assesses the dynamics of ribosomal flux on transcripts
Tomuro, K.; Mito, M.; Toh, H.; Kawamoto, N.; Miyake, T.; Chow, S. Y. A.; Doi, M.; Ikeuchi, Y.; Shichino, Y.; Iwasaki, S.
10.1101/2023.06.20.545829 — molecular biology — Posted on 2024-04-10
3218 Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms
Bendzunas, G.; Byrne, D. P.; Shrestha, S.; Daly, L. A.; Oswald, S. O.; Katiyar, S.; Venkat, A.; Yeung, W.; Eyers, C. E.; Eyers, P. A.; Kannan, N.
10.1101/2023.10.05.561145 — biochemistry — Posted on 2024-04-10
3220 A Ratiometric Catalog of Protein Isoform Shifts in the Cardiac Fetal Gene Program
Han, Y.; Wennersten, S. A.; Pandi, B. P.; Ng, D. C.; Lau, E.; Lam, M. P. Y.
10.1101/2024.04.09.588716 — biochemistry — Posted on 2024-04-10
3221 Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST
Sprenger, H.-G.; Mittenbuehler, M. J.; Sun, Y.; Van Vranken, J. G.; Schindler, S.; Jayaraj, A.; Khetarpal, S. A.; Vargas-Castillo, A.; Puszynska, A. M.; Spinelli, J. B.; Armani, A.; Kunchok, T.; Ryback, B.; Seo, H.-S.; Song, K.; Sebastian, L.; O Young, C.; Braithwaite, C.; Dhe-Paganon, S.; Burger, N.; Mills, E. L.; Gygi, S. P.; Arthanari, H.; Chouchani, E. T.; Sabatini, D. M.; Spiegelman, B. M.
10.1101/2024.04.10.588849 — molecular biology — Posted on 2024-04-10
3222 Metaproteomics and DNA metabarcoding as tools to assess dietary intake in humans
Petrone, B. L.; Bartlett, A.; Jiang, S.; Korenek, A.; Vintila, S.; Tenekjian, C. B.; Yancy, W. S.; David, L. A.; Kleiner, M.
10.1101/2024.04.09.588275 — molecular biology — Posted on 2024-04-10
3223 Two-ended recombination at a Flp-nickase-broken replication fork
Elango, R.; Nilavar, N.; Li, A. G.; Duffey, E. E.; Jiang, Y.; Nguyen, D.; Abakir, A.; Willis, N. A.; Houseley, J.; Scully, R.
10.1101/2024.04.10.588130 — molecular biology — Posted on 2024-04-10
3225 Active state structures of a bistable visual opsin bound to G proteins
Tejero, O.; Pamula, F. K.; Koyanagi, M.; Nagata, T.; Afanasyev, P.; Das, I.; Deupi, X.; Sheves, M.; Terakita, A.; Schertler, G. F. X.; Rodrigues, M. J.; Tsai, C.-J.
10.1101/2024.04.09.588704 — biochemistry — Posted on 2024-04-10
3226 Quantification of tissue creatine content using capillary electrophoresis
Choi, Y. J.; Bautista, A. P.; Terrill, J. R.; Arthur, P. G.; Pillow, J. J.
10.1101/2024.04.09.588648 — biochemistry — Posted on 2024-04-10
3227 MCM Double Hexamer Loading Visualised with Human Proteins
Weissmann, F.; Greiwe, J. F.; Pühringer, T.; Miller, T. C. R.; Diffley, J. F. X.; Costa, A.
10.1101/2024.04.10.588848 — biochemistry — Posted on 2024-04-10
3229 Macroevolutionary inference of complex modes of chromosomal speciation in a cosmopolitan plant lineage
Tribble, C. M.; Marquez Corro, J. I.; May, M. R.; Hipp, A. L.; Escudero, M.; Zenil-Ferguson, R.
10.1101/2023.09.05.556433 — evolutionary biology — Posted on 2024-04-10
3231 Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden
Weigl, M.; Krammer, T. L.; Pultar, M.; Wieser, M.; Chaib, S.; Suda, M.; Diendorfer, A.; Khamina, K.; Giorgadze, N.; Pirtskhalava, T.; Johnson, K. O.; Inman, C. L.; Ailing, X.; Laemmermann, I.; Meixner, B.; Wang, L.; Xu, M.; Grillari, R.; Ogrodnik, M. B.; Tchkonia, T.; Hackl, M.; Kirkland, J. L.; Grillari, J.
10.1101/2024.04.10.588794 — molecular biology — Posted on 2024-04-10
3232 Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system
Datta, P.; Rhee, K. D.; Staudt, R. J.; Thompson, J. M.; Hsu, Y.; Hassan, S.; Drack, A. V.; Seo, S.
10.1101/2024.04.10.588864 — molecular biology — Posted on 2024-04-10
3243 TRIP12 governs DNA Polymerase β involvement in DNA damage response and repair
Inanc, B.; Fang, Q.; Andrews, J. F.; Zeng, X.; Clark, J.; Li, J.; Dey, N. B.; Ibrahim, M.; Sykora, P.; Yu, Z.; Braganza, A.; Verheij, M.; Jonkers, J.; Yates, N. A.; Vens, C.; Sobol, R. W.
10.1101/2024.04.08.588474 — cancer biology — Posted on 2024-04-10
3244 Assembly of the Bacterial Ribosome with Circularly Permuted rRNA
Williamson, J. R.; Dong, X.; Sheng, K.; Gebert, L. F. R.; Aiyer, S.; MacRae, I.; Lyumkis, D.
10.1101/2024.04.10.588894 — biophysics — Posted on 2024-04-10
3246 Ovoselenol, a Selenium-containing AnOoxidant Derived from Convergent Evolution
Kayrouz, C. M.; Ireland, K. A.; Ying, V.; Davis, K. M.; Seyedsaamdost, M. R.
10.1101/2024.04.10.588772 — biochemistry — Posted on 2024-04-10
3248 Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14
Peri, L.; Matzov, D.; Huxley, D. R.; Rainish, A.; Fierro, F.; Sapir, L.; Pfeiffer, T.; Waterloo, L.; Huebner, H.; Weikert, D.; Peleg, Y.; Gmeiner, P.; Mccormick, P.; Niv, M. Y.; Shalev-Benami, M.
10.1101/2024.04.10.588278 — biochemistry — Posted on 2024-04-10
3253 Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings
Ye, Z.; Shelton, A. M.; Shaker, J. R.; Boussard, J. M.; Colonell, J.; Birman, D.; Manavi, S.; Chen, S.; Windolf, C.; Hurwitz, C.; Namima, T.; Pedraja, F.; Weiss, S.; Raducanu, B.; Ness, T.; Jia, X.; Mastroberardino, G.; Rossi, L. F.; Carandini, M.; Hausser, M.; Einevoll, G. T.; Laurent, G.; Sawtell, N. B.; Bair, W.; Pasupathy, A.; Mora-Lopez, C.; Dutta, B.; Paninski, L.; Siegle, J. H.; Koch, C.; Olsen, S. R.; Harris, T. D.; Steinmetz, N. A.
10.1101/2023.08.23.554527 — neuroscience — Posted on 2024-04-10
3254 Brain aromatase dynamics reflect parental experience and behaviour in male mice
Duarte-Guterman, P.; Skandalis, D. A.; Merkl, A.; Geissler, D. B.; Ehret, G.
10.1101/2023.07.15.549144 — neuroscience — Posted on 2024-04-10
3265 Predictive posture stabilization before contact with moving objects: equivalence of smooth pursuit tracking and peripheral vision
Sinha, O.; Rosenquist, T. S.; Fedorshak, A. R.; Kpankpa, J.; Albenze, E.; Bonnet, C.; Bertucco, M.; Kurtzer, I.; Singh, T.
10.1101/2024.04.07.588455 — neuroscience — Posted on 2024-04-10
3270 Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly
Chen, S.; Wang, J.; Jiang, S.; Fan, Y.; Zhao, Y.; Wan, Z.; Zhou, Q.; Chen, Y.; Chen, P.
10.1101/2024.04.07.588443 — bioengineering — Posted on 2024-04-10
3272 Parameterizing Pantherinae: de novo mutation rate estimates from Panthera and Neofelis pedigrees
Armstrong, E. E.; Carey, S. B.; Harkess, A.; Zenato Lazzari, G.; Solari, K. A.; Maldonado, J. E.; Fleischer, R. C.; Aziz, N.; Walsh, P.; Koepfli, K.-P.; Eizirik, E.; Petrov, D. A.; Campana, M.
10.1101/2024.04.06.587788 — evolutionary biology — Posted on 2024-04-10
3274 Positive Selection on Rare Variants Underlying the Cold Adaptation of Wild Boar
Chen, J.; Jakovlic, I.; Sablin, M.; Xia, S.; Xu, z.; Guo, Y.; Kuang, R.; Zhong, J.; Jia, Y.; Thi, T. N. T.; Yang, H.; Ma, H.; Sprem, N.; Liu, D.; Zhao, Y.; Zhao, S.
10.1101/2024.04.07.588424 — evolutionary biology — Posted on 2024-04-10
3275 Diet and Size-at-Birth Affect Larval Rockfish Condition and Survival
Walsh, K. A.; Thompson, A. R.; Kwan, G. T.; Semmens, B. X.; Fennie, H. W.; Swalethorp, R.
10.1101/2024.04.07.588270 — ecology — Posted on 2024-04-10
3276 Lateral cell polarization drives organization of epithelia in sea anemone embryos and embryonic cell aggregates
Atajanova, T.; Kang, E. M.; Postnikova, A.; Price, A. L.; Doerr, S.; Du, M.; Ugenti, A.; Ragkousi, K.
10.1101/2024.04.07.588493 — developmental biology — Posted on 2024-04-10
3277 CAR Tregs mediate linked suppression and infectious tolerance in islet transplantation
Wardell, C.; Fung, V.; Chen, E.; Haque, M.; Gillies, J.; Spanier, J.; Mojibian, M.; Fife, B. T.; Levings, M. K.
10.1101/2024.04.06.588414 — immunology — Posted on 2024-04-10
3280 Exploring new nanopore sensors from the aerolysin family
Cirauqui Diaz, N.; Bada Juarez, J. F.; Meireles, F. A.; Barry, J.; Bokori-Brown, M.; Marcaida, M. J.; Cao, C.; Dal Peraro, M.
10.1101/2024.04.07.588449 — biophysics — Posted on 2024-04-10
3284 Deep learning-based detection of murine congenital heart defects from μCT scans
Nguyen, H.; Desgrange, A.; Ochandorena-Saa, A.; Benhamo, V.; Meilhac, S.; Zimmer, C.
10.1101/2024.04.06.588383 — developmental biology — Posted on 2024-04-10
3285 Macromolecular and cytological changes in fission yeast G0 nuclei
Tan, Z. Y.; Cai, S.; Paithankar, S. A.; Nie, X.; Shi, J.; Gan, L.
10.1101/2020.01.11.899559 — cell biology — Posted on 2024-04-10
3286 Monolayer force generation and transmission is dictated by focal adhesion distribution
Davis, J. R.; Solowiej-Wedderburn, J.; Vega, S. L.; Burdick, J. A.; Dunlop, C.; Tapon, N.
10.1101/2024.04.10.588783 — biophysics — Posted on 2024-04-10
3288 Enhanced Fc Receptor expression and distinct immunomodulatory properties of neutrophils during HIV-1 infection and therapy
Marsile-Medun, S.; Souchard, M.; Abba Moussa, D.; Lorin, V.; Mouquet, H.; Reynaud, E.; Dibsy, R.; TUAILLON, E.; MURIAUX, D.; Pugniere, M.; Ngo, G.; Naranjo-Gomez, M.; Pelegrin, M.
10.1101/2024.02.13.580065 — immunology — Posted on 2024-04-10
3295 Spatial neglect after stroke is reduced when lying inside a 3T MRI scanner
Karnath, H.-O.; Rosenzopf, H.; Stammler, B.; Smaczny, S.; Lindner, A.
10.1101/2022.08.01.502290 — neuroscience — Posted on 2024-04-10
3298 Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms
Lambourne, L.; Mattioli, K.; Santoso, C.; Sheynkman, G.; Inukai, S.; Kaundal, B.; Berenson, A.; Spirohn-Fitzgerald, K.; Bhattacharjee, A.; Rothman, E.; Shrestha, S.; Laval, F.; Yang, Z.; Bisht, D.; Sewell, J. A.; Li, G.; Prasad, A.; Phanor, S.; Lane, R.; Campbell, D. M.; Hunt, T.; Balcha, D.; Gebbia, M.; Twizere, J.-C.; Hao, T.; Frankish, A.; Riback, J.; Salomonis, N.; Calderwood, M. A.; Hill, D. E.; Sahni, N.; Vidal, M.; Bulyk, M. L.; Fuxman Bass, J. I.
10.1101/2024.03.12.584681 — systems biology — Posted on 2024-04-10
3300 CATD: A reproducible pipeline for selecting cell-type deconvolution methods across tissues
Vathrakokoili Pournara, A.; Miao, Z.; Beker, O. Y.; Nolte, N. F.; Brazma, A.; Papatheodorou, I.
10.1101/2023.01.19.523443 — bioinformatics — Posted on 2024-04-10
3305 Peroxidasin is associated with a mesenchymal-like transcriptional phenotype and promotes invasion in metastatic melanoma
Smith-Diaz, C. C.; Kumar, A.; Das, A.; Pace, P.; Chitcholtan, K.; Magon, N. J.; Hossain, S. H. M.; Eccles, M. R.; Winterbourn, C. C.; Paumann-Page, M.
10.1101/2024.04.05.588346 — cancer biology — Posted on 2024-04-10
3308 Predation by a ciliate community mediates temperature and nutrient effects on a peatland prey prokaryotic community.
DeWitt, K.; Carrell, A.; Rocca, J.; Votzke, S.; Yammine, A.; Peralta, A. L.; Weston, D. J.; Pelletier, D. A.; Gibert, J. P.
10.1101/2024.04.05.588366 — ecology — Posted on 2024-04-10
3311 Explicit and implicit locomotor learning in individuals with chronic hemiparetic stroke
Wood, J. M.; Thompson, E. M.; Wright, H.; Festa, L.; Morton, S. M.; Reisman, D. S.; Kim, H. E.
10.1101/2024.02.04.578807 — neuroscience — Posted on 2024-04-10
3312 Multimodal assessment of acute stress dynamics using an Aversive Video Paradigm (AVP)
Roy, S.; Fan, Y.; Mosayebi-Samani, M.; Claus, M.; Mutlu, N.; Kleinsorge, T.; Nitsche, M.
10.1101/2024.04.05.588254 — neuroscience — Posted on 2024-04-10
3313 Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice
Shannon, T.; Levine, N.; Dirickson, R.; Shen, Y.; Cotter, C.; Yi, Y.-J.; Rajjoub, N.; Pardo-Manuel de Villena, F.; Kokiko-Cochran, O.; Gu, B.
10.1101/2024.04.05.588288 — neuroscience — Posted on 2024-04-10
3314 H-current modulation of cortical Up and Down states
Dalla Porta, L.; Barbero-Castillo, A.; Sanchez-Sanchez, J. M.; Cancino, N.; Sanchez-Vives, M. V.
10.1101/2024.04.05.588281 — neuroscience — Posted on 2024-04-10
3315 Task-specific topology of brain networks supporting working memory and inhibition
Adamovich, T.; Ismatullina, V.; Chipeeva, N.; Zakharov, I.; Feklicheva, I.; Malykh, S.
10.1101/2024.04.05.588287 — neuroscience — Posted on 2024-04-10
3318 Resource: A Curated Database of Brain-Related Functional Gene Sets (Brain.GMT)
Hagenauer, M. H.; Sannah, Y.; Hebda-Bauer, E.; Rhoads, C.; O'Connor, A. M.; Watson, S. J.; Akil, H.
10.1101/2024.04.05.588301 — neuroscience — Posted on 2024-04-10
3319 RSL4 regulatory network acts as an early driver of root hair growth at low temperature in Arabidopsis thaliana
Urzua, T.; Berdion Gabarain, V.; Moyano, T.; Ferrero, L.; Sugimoto, K.; Sanguinet, K.; Meneses, C.; Chan, R. L.; Ariel, F.; Alvarez, J. M.; Estevez, J.
10.1101/2024.04.09.588718 — plant biology — Posted on 2024-04-10
3323 Multi-pronged analysis of pediatric low-grade glioma reveals a unique tumor microenvironment associated with BRAF alterations
Zahedi, S.; Riemondy, K. A.; Griesinger, A. M.; Donson, A.; Fu, R.; Crespo, M.; DeSisto, J.; Groat, M. M.; Bratbak, E.; Green, A.; Hankinson, T. C.; Handler, M.; Vibhakar, R.; Willard, N.; Foreman, N. K.; Mulcahy Levy, J. M.
10.1101/2024.04.05.588294 — cancer biology — Posted on 2024-04-10
3326 A heterogeneous pharmaco-transcriptomic landscape induced by targeting a single oncogenic kinase
Giglio, R. M.; Hou, N.; Wyatt, A.; Hong, J.; Shi, L.; Vaikunthan, M.; Fuchs, H.; Nima, J. P.; Malinowski, S. W.; Ligon, K. L.; McFaline-Figueroa, J. R.; Yosef, N.; Azizi, E.; McFaline-Figueroa, J. L.
10.1101/2024.04.08.587960 — genomics — Posted on 2024-04-10
3327 Testis- and ovary-expressed polo transcripts and gene duplications affect male fertility when expressed in the germline
Najera, P.; Dratler, O. A.; Mai, A. B.; Elizarraras, M.; Vanchinathan, R.; Gonzales, C. A.; Meisel, R. P.
10.1101/2024.04.05.588298 — genetics — Posted on 2024-04-10
3331 CryoRhodopsins: a comprehensive characterization of a group of microbial rhodopsins from cold environments
Lamm, G. H. U.; Marin, E.; Alekseev, A.; Schellbach, A. V.; Stetsenko, A.; Bourenkov, G.; Borshchevskiy, V.; Asido, M.; Agthe, M.; Engilberge, S.; Rose, S. L.; Caramello, N.; Royant, A.; Schneider, T. R.; Bateman, A. I.; Mager, T.; Moser, T.; Wachtveitl, J.; Guskov, A.; Kovalev, K.
10.1101/2024.01.15.575777 — biophysics — Posted on 2024-04-10
3333 WITHDRAWN: Nitrogen sources enhance siderophore-mediated competition for iron between potato common scab and late blight causative agents
Stulanovic, N.; Kerdel, Y.; Rezende, L.; Deflandre, B.; Burguet, P.; Belde, L.; Denoel, R.; Tellatin, D.; Rigolet, A.; Hanikenne, M.; Quinton, L.; Ongena, M.; Rigali, S.
10.1101/2023.10.11.561833 — microbiology — Posted on 2024-04-10
3335 Harnessing RNA-based DNA repair pathways for targeted gene editing
Huynh, N.; Kwon, S.; McMurrough, T. A.; Loedige, K. W.; Tavassoli, M.; Weijuan, S.; Quin, H.; Luu, K.; Dharni, B.; Haydaychuk, O.; Stead, B. E.; Edgell, D.
10.1101/2024.04.09.588775 — molecular biology — Posted on 2024-04-10
3337 Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Rademacher, K. L.; Doric, Z.; Haddad, D.; Mamaligas, A.; Liao, S.-C.; Creed, R.; Kano, K.; Chatterton, Z.; Fu, Y.; Garcia, J. H.; Vance, V.; Sei, Y.; Kreitzer, A.; Halliday, G.; Nelson, A.; Margolis, E.; Nakamura, K. L.
10.1101/2024.04.05.588321 — neuroscience — Posted on 2024-04-10
3338 Hippocampal sharp wave ripples and coincident cortical ripples orchestrate human semantic networks
Mishra, A.; Akkol, S.; Espinal, E.; Markowitz, N.; Gherman, S.; Tostaeva, G.; Freund, E.; Mehta, A.; Bickel, S.
10.1101/2024.04.10.588795 — neuroscience — Posted on 2024-04-10
3342 Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications
Giniunaite, R.; Sharma, R.; Maddocks, J. H.; Kriaucionis, S.; Petkeviciute-Gerlach, D.
10.1101/2024.04.06.588401 — biophysics — Posted on 2024-04-10
3344 Repeat-based holocentromeres of the woodrush Luzula sylvatica reveal new insights into the evolutionary transition from mono- to holocentricity
Mata-Sucre, Y.; Kratka, M.; Oliveira, L.; Neumann, P.; Macas, J.; Schubert, V.; Huettel, B.; Kejnovsky, E.; Houben, A.; Pedrosa-Harand, A.; Souza, G.; Marques, A.
10.1101/2024.04.05.588299 — genomics — Posted on 2024-04-10
3345 Features of the DNA Escherichia coli RecN interaction revealed by fluorescence microscopy and single-molecule methods
Roshektaeva, V. D.; Alekseev, A. A.; Vedyaykin, A. D.; Vinnik, V. A.; Baitin, D. M.; Bakhlanov, I. V.; Pobegalov, G. E.; Khodorkovskii, M. A.; Morozova, N. E.
10.1101/2024.04.09.588753 — molecular biology — Posted on 2024-04-10
3346 Interplay between the Xer recombination system and the dissemination of antibioresistance in Acinetobacter baumannii
Blanchais, C.; Pages, C.; Campos, M.; Boubekeur, K.; Contarin, R.; Orlando, M.; Siguier, P.; Laaberki, M.-H.; Cornet, F.; Charpentier, X.; ROUSSEAU, P.
10.1101/2024.04.09.588662 — microbiology — Posted on 2024-04-10
3348 Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments
Rasmussen, T. S.; Mao, X.; Forster, S.; Larsen, S. B.; von Munchow, A.; Tranaes, K. D.; Brunse, A.; Larsen, F.; Castro-Mejia, J. L.; Adamberg, S.; Hansen, A. K.; Adamberg, K.; Hansen, C. H. F.; Nielsen, D. S.
10.1101/2023.03.17.532897 — microbiology — Posted on 2024-04-10
3349 Rethinking sinking: Imaging flow fields of natural marine aggregates to infer porosity-dependent changes in sinking velocity and carbon flux
Flintrop, C. M.; Ahmerkamp, S.; Moradi, N.; Klawonn, I.; März, J.; Hörstmann, C.; Kiko, R.; Khalili, A.; Grossart, H.-P.; Alvarez-Salgado, X. A.; Aristegui Ruiz, J.; Iversen, M. H.
10.1101/2023.09.05.555549 — biophysics — Posted on 2024-04-10
3353 A Myelin Map of Trunk Folds in the Elephant Trigeminal Nucleus
Reveyaz, N.; Schneeweiss, U.; Heise, O.; Gerhardt, B.; Gui, A. M.; Kaufmann, L. V.; Alfken, J.; Reichmann, J.; Salditt, T.; Hildebrandt, T. B.; Brecht, M.
10.1101/2023.11.15.567239 — neuroscience — Posted on 2024-04-10
3355 Nova-ST: Nano-Patterned Ultra-Dense platform for spatial transcriptomics
Poovathingal, S.; Davie, K.; Vandepoel, R.; Poulvellarie, N.; Verfaillie, A.; Corthout, N.; Aerts, S.
10.1101/2024.02.22.581576 — genomics — Posted on 2024-04-10
3357 Genomic signatures associated with the evolutionary loss of egg yolk in parasitoid wasps
Zhao, X.; Liu, Y.; Yang, Y.; He, C.; Chan, K. C.; Lin, H.; Fang, Q.; Ye, G.; Ye, X.
10.1101/2023.12.30.573744 — evolutionary biology — Posted on 2024-04-10
3360 CRISPR screens and lectin microarrays identify novel high mannose N-glycan regulators
Tsui, C. K.; Twells, N.; Doan, E.; Woo, J.; Khosrojerdi, N.; Brooks, J.; Kulepa, A.; Webster, B.; Mahal, L. K.; Dillin, A.
10.1101/2023.10.23.563662 — cell biology — Posted on 2024-04-10
3362 Reconstructing bat antiviral immunity using epithelial organoids
Kellner, M. J.; Zelger, P.; Monteil, V.; Pei, G.; Onji, M.; Nayak, K.; Zilbauer, M.; Balkema-Buschmann, A.; Dorhoi, A.; Mirazimi, A.; Penninger, J. M.
10.1101/2024.04.05.588241 — immunology — Posted on 2024-04-10
3363 Identifying immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors
May, D. H.; Woodhouse, S.; Zahid, H. J.; Elyanow, R.; Doroschak, K.; Noakes, M. T.; Taniguchi, R.; Yang, Z.; Grino, J.; Byron, R.; Oaks, J.; Sherwood, A.; Greissl, J.; Chen-Harris, H.; Howie, B.; Robins, H. S.
10.1101/2024.03.26.583354 — immunology — Posted on 2024-04-10
3371 Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation
Schaller, M. L.; Sykes, M. L.; Mecano, J.; Solanki, S.; Huang, W.; Rebernick, R. J.; Beydoun, S.; Wang, E.; Bugarin-Lapuz, A.; Shah, Y. M.; Leiser, S. F.
10.1101/2024.04.05.588360 — physiology — Posted on 2024-04-10
3372 Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10 expression
Corriveau, J.; Monot, P.; Delisle, C.; Goyette, M.-A.; El Bakkouri, Y.; Hoang, T.; Cote, J.-F.; Gratton, J.-P.
10.1101/2024.04.05.588280 — cancer biology — Posted on 2024-04-10
3375 An Ensemble Penalized Regression Method for Multi-ancestry Polygenic Risk Prediction
Zhang, J.; Zhan, J.; Jin, J.; Ma, C.; Zhao, R.; O'Connell, J.; Jiang, Y.; 23andMe Research Team, ; Koelsch, B. L.; Zhang, H.; Chatterjee, N.
10.1101/2023.03.15.532652 — genetics — Posted on 2024-04-10
3376 Ongoing introgression of a secondary sexual plumage trait in a stable avian hybrid zone
Long, K. M.; Rivera-Colon, A. G.; Bennett, K. F.; Catchen, J. M.; Braun, M. J.; Brawn, J. D.
10.1101/2023.03.30.535000 — evolutionary biology — Posted on 2024-04-10
3378 Molecular insights into G protein coupling specificity at a class A GPCR
Casiraghi, M.; Wang, H.; Brennan, P.; Habrian, C.; Hubner, H.; Schmidt, M. F.; Maul, L.; Pani, B.; Bahriz, S. M.; Xu, B.; White, E.; Sunahara, R. K.; Xiang, Y. K.; Lefkowitz, R. J.; Isacoff, E. Y.; Nucci, N.; Gmeiner, P.; Lerch, M.; Kobilka, B. K.
10.1101/2024.03.28.587240 — molecular biology — Posted on 2024-04-10
3381 HR3/RORα-mediated cholesterol sensing regulates TOR signaling
Lassen, M.; Pardee, K.; Pedersen, L. H.; Kubrak, O.; Koyama, T.; Necakov, S.; Liu, S.; Kuksis, A.; Lajoie, G.; Edwards, A.; Teleman, A. A.; Larsen, M. R.; Krause, H. M.; Texada, M. J.; Rewitz, K.
10.1101/2024.04.09.588676 — cell biology — Posted on 2024-04-09
3382 Modeling CSF circulation and the glymphatic system during infusion using subject specific intracranial pressures and brain geometries
Dreyer, L. W.; Eklund, A.; Rognes, M. E.; Malm, J.; Qvarlander, S.; Stoverud, K.-H.; Mardal, K.-A.; Vinje, V.
10.1101/2024.04.08.588508 — neuroscience — Posted on 2024-04-09
3385 Control of GSK3beta nuclear localization by amino acid signaling requires GATOR1 but is mTORC1 independent
Schwendener Forkel, D.; Ibazebo, O.; Soha, S.; Bautista, S. J.; Impellizzeri, S.; Botelho, R. J.; Hesketh, G.; Gingras, A.-C.; Antonescu, C. N.
10.1101/2024.04.09.588669 — cell biology — Posted on 2024-04-09
3386 Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes
Wong, S.-S.; Monteiro, J. M.; Chang, C.-C.; Peng, M.; Mohamad, N.; Steinacker, T. L.; Saurya, S.; Wainman, A.; Raff, J. W.
10.1101/2024.04.09.588708 — cell biology — Posted on 2024-04-09
3388 Selective modification of ascending spinal outputs in acute and neuropathic pain states
Yarmolinsky, D. A.; Zeng, X.; MacKinnon-Booth, N.; Greene, C.; Kim, C.; Woolf, C. J.
10.1101/2024.04.08.588581 — neuroscience — Posted on 2024-04-09
3390 Pattern formation along signaling gradients driven by active droplet behaviour of cell groups
Ford, H. Z.; Celora, G. L.; Westbrook, E. R.; Dalwadi, M. P.; Walker, B. J.; Baumann, H.; Weijer, C. J.; Pearce, P.; Chubb, J. R.
10.1101/2024.04.08.588511 — biophysics — Posted on 2024-04-09
3392 Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A
Shaw, A. L.; Suresh, S.; Parson, M. A.; Harris, N. J.; Jenkins, M. L.; Yip, C. K.; Burke, J. E.
10.1101/2024.04.09.588654 — biochemistry — Posted on 2024-04-09
3396 Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes
Schmidt, T. L.; Endersby-Harshman, N.; van Rooyen, A.; Katsuele, M.; Vinit, R.; Robinson, L.; Laman, M.; Karl, S.; Hoffmann, A. A.
10.1101/2024.04.09.588653 — evolutionary biology — Posted on 2024-04-09
3397 Plasmodium falciparum protein phosphatase PP7 is required for early ring-stage development
Patel, A.; Rey, J. A.; Flynn, H. R.; Kousis, K.; Skehel, M. J.; Blackman, M.; Baker, D. A.
10.1101/2024.04.08.588616 — molecular biology — Posted on 2024-04-09
3398 Nitrosation of CD36 regulates endothelial function and serum lipids
Luse, M. A.; Schug, W. J.; Dunaway, L. S.; Nyshadham, S.; Loeb, S. A.; Carvalho, A.; Tessema, R.; Pavelec, C. M.; Keller, T. C. S.; Shu, X.; Ruddiman, C. A.; Kosmach, A.; Sveeggen, T.; Mitchell, R.; Bagher, P.; Minshall, R. D.; Leitinger, N.; Columbus, L.; Levental, K. R.; Levental, I.; Cortese-Krott, M.; Isakson, B.
10.1101/2024.04.09.588733 — molecular biology — Posted on 2024-04-09
3399 Features of the DNA Escherichia coli RecN interaction revealed by fluorescence microscopy and single-molecule methods
Roshektaeva, V. D.; Alekseev, A. A.; Vedyaykin, A. D.; Vinnik, V. A.; Baitin, D. M.; Bakhlanov, I. V.; Pobegalov, G. E.; Khodorkovskii, M. A.; Morozova, N. E.
10.1101/2024.04.09.588753 — molecular biology — Posted on 2024-04-09
3400 Interplay between the Xer recombination system and the dissemination of antibioresistance in Acinetobacter baumannii
Blanchais, C.; Pages, C.; Campos, M.; Boubekeur, K.; Contarin, R.; Orlando, M.; Siguier, P.; Laaberki, M.-H.; Cornet, F.; Charpentier, X.; ROUSSEAU, P.
10.1101/2024.04.09.588662 — microbiology — Posted on 2024-04-09
3402 Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and B-lactam antibiotics.
Hernandez, D. M.; Marzouk, M.; Cole, M.; Fortoul, M. C.; Kethireddy, S. R.; Contractor, R.; Islam, H.; Moulder, T.; Kalifa, A. R.; Meneses, E. M.; Mendoza, M. B.; Thomas, R.; Masud, S.; Pubien, S.; Milanes, P.; Diaz-Tang, G.; Lopatkin, A. J.; Smith, R. P.
10.1101/2024.04.09.588696 — microbiology — Posted on 2024-04-09
3403 Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration
Ingram, Z.; Kline, C.; Hughson, A. K.; Singh, P. K.; Fischer, H. L.; Sowd, G. A.; Watkins, S. C.; Kane, M.; Engelman, A. N.; Ambrose, Z.
10.1101/2024.04.08.588584 — microbiology — Posted on 2024-04-09
3405 Microbial Analysis and Sanitization of Hydroponic Farming Facilities in Singapore
Tham, C.; Zwe, Y. H.; Ten, M.; Ng, G.; Toh, J. Y. L.; Poh, B. L.; Zhou, W.; Li, D.
10.1101/2024.04.08.588599 — microbiology — Posted on 2024-04-09
3409 Chloride Homeostasis Regulates cGAS-STING Signaling
Morse, J.; Wang, D.; Mei, S.; Whitham, D.; Hladun, C.; Darie, C. C.; Sintim, H. O.; Wang, M.; Leung, K.
10.1101/2024.04.08.588475 — cell biology — Posted on 2024-04-09
3410 Characterizing nascent transcription patterns of PROMPTs, eRNAs, and readthrough transcripts in the ENCODE4 deeply profiled cell lines
McShane, A.; Venkata Narayanan, I.; Paulsen, M. T.; Ashaka, M.; Blinkiewicz, H.; Yang, N. T.; Magnuson, B.; Bedi, K.; Wilson, T. E.; Ljungman, M.
10.1101/2024.04.09.588612 — molecular biology — Posted on 2024-04-09
3411 Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus
Ochner, H.; Boehning, J.; Wang, Z.; Tarafder, A. K.; Caspy, I.; Bharat, T.
10.1101/2024.04.09.588664 — microbiology — Posted on 2024-04-09
3412 The chemoreceptor controlling the Wsp-like transduction pathway in Halomonas titanicae KHS3 binds purine derivatives
Ramos Ricciuti, F. E.; Herrera Seitz, M. K.; Gasperotti, A. F.; Boyko, A.; Jung, K.; Bellinzoni, M.; Studdert, C. A.; Lisa, M.-N.
10.1101/2024.04.09.588698 — microbiology — Posted on 2024-04-09
3413 The gut microbiota is essential for Trichinella spiralis-evoked suppression of colitis
Sun, H.; Long, S. R.; Jiang, M.; Zhang, H. R.; Wang, J. J.; Liao, Z. X.; Cui, J.; Wang, Z. Q.
10.1101/2024.04.09.588742 — microbiology — Posted on 2024-04-09
3415 Antimicrobial effect of two endemic Dominican plants on microorganisms that cause otitis
Rivas-Ramirez, J. A.; Morales-Mercedes, M. M.; Guzman-Recio, J. A.; Garcia, M. I. I.; Disla, A. V.; Guzman-Marte, A. E.; Ramirez-Ramirez, M.; Meji-De La Cruz, D.; Vasquez-Tineo, M.
10.1101/2024.04.09.588785 — microbiology — Posted on 2024-04-09
3417 A Deep Learning-Based Evaluation for Microscopic Agglutination Test
Nakano, R.; Oyamada, Y.; Ozuru, R.; Miyahara, S.; Yoshimura, M.; Hiromatsu, K.
10.1101/2024.04.09.588741 — microbiology — Posted on 2024-04-09
3421 Combined Dendritic Cell And Anti-TIGIT Immunotherapy Potentiate Trail+ Memory NK Cells Against HIV-1 Infected Cells
Cerrillo, I. S.; Popova, O.; Lera, M. A.; Tsukalov, I.; Mirabent, M. C.; Santos, I.; Fraile, L. G.; Fuentes, P.; Arevalo, C. D.; Alcain, J.; Gaona, N. S.; Diez, M. L.; Calleja, C. M.; Alfranca, A.; Genesca, M.; Prado, J. G.; Vbrnac, V.; Balazs, A.; Buzon, M. J.; Toribio, M. l.; Fernandez, M. A. M.; Madrid, F. S.; Martin-Gayo, E.
10.1101/2024.04.09.587160 — immunology — Posted on 2024-04-09
3422 Gossamer: Scaling Image Processing and Reconstruction to Whole Brains
Marrett, K.; Moradi, K.; Park, C. S.; Yan, M.; Choi, C.; Zhu, M.; Akram, M.; Nanda, S.; Xue, Q.; Mun, H.-S.; Gutierez, A.; Rudd, M.; Zingg, B.; Magat, G.; Wijaya, K.; Dong, H.; Yang, X. W.; Cong, J.
10.1101/2024.04.07.588466 — neuroscience — Posted on 2024-04-09
3425 A heterogenous pharmaco-transcriptomic landscape induced by targeting a single oncogenic kinase
Giglio, R. M.; Hou, N.; Wyatt, A.; Hong, J.; Shi, L.; Vaikunthan, M.; Fuchs, H.; Nima, J. P.; Malinowski, S. W.; Ligon, K. L.; McFaline-Figueroa, J. R.; Yosef, N.; Azizi, E.; McFaline-Figueroa, J. L.
10.1101/2024.04.08.587960 — genomics — Posted on 2024-04-09
3426 The potential of gene drive releases in malaria vector species to reduce the malaria burden in different African environments
Hancock, P. A.; North, A.; Leach, A. W.; Winskill, P.; Ghani, A.; Godfray, H. C. J.; Burt, A.; Mumford, J. D.
10.1101/2024.04.08.588513 — genetics — Posted on 2024-04-09
3428 The Fat/Hippo pathway drives photoperiod-induced wing length polyphenism
Gudmunds, E.; Palahi, A.; Armisen, D.; Scofield, D. G.; Eriksen, F. D.; Khila, A.; Husby, A.
10.1101/2024.04.05.588279 — evolutionary biology — Posted on 2024-04-09
3432 Kidney collecting duct cell type composition is regulated by Notch signaling via modulation of mTORC1
deRiso, J. L.; Mukherjee, M.; Janga, M.; Simmons, A. L.; Kareta, M.; Tao, J.; Chandrasekar, I.; Surendran, K.
10.1101/2024.04.09.587573 — developmental biology — Posted on 2024-04-09
3434 Translational control of microglial inflammatory and neurodegenerative responses
Bermudez, S.; Choi, J.; Vogel, J. W.; Kim, S.; Mahmood, N.; Zhu, V.; Cozachenco, D.; Yaqubi, M.; Zhou, L.; Stratton, J.; Hansson, O.; Healy, L.; Aguilar-Valles, A.; Sonenberg, N.
10.1101/2024.04.06.587750 — neuroscience — Posted on 2024-04-09
3436 Creative tempo: Spatiotemporal dynamics of the default mode network in improvisational musicians
Watters, H. N.; Fazili, A.; Daley, L.; Belden, A.; LaGrow, T. J.; Bolt, T. S.; Loui, P.; Keilholz, S.
10.1101/2024.04.07.588391 — neuroscience — Posted on 2024-04-09
3438 MicroRNAs and PFAS: A Pilot Study in Blood Collected from Firefighters
Zhang, X.; Sands, M.; La Frano, M.; Spinella, M.; Masoud, F.; Fields, C. J.; Madak-Erdogan, Z.; Jensen, T.; Irudayaraj, J.
10.1101/2024.04.05.588341 — pharmacology and toxicology — Posted on 2024-04-09
3439 Cancer cell - fibroblast crosstalk via HB-EGF/EGFR/MEK signalling promotes macrophage recruitment in squamous cell carcinoma
Giangreco, G.; Rullan, A.; Naito, Y.; Biwas, D.; Liu, Y.-H.; Hooper, S.; Nenclares, P.; Bhide, S.; Cheang, M.; Chakravarty, P.; Hirata, E.; Swanton, C.; Melcher, A.; Harrington, K.; Sahai, E.
10.1101/2023.07.13.548733 — cancer biology — Posted on 2024-04-09
3440 Natural language processing charts transcriptome evolution to design combination cancer therapies
Jassim, A.; Nimmervoll, B. V.; Terranova, S.; Nathan, E.; Masih, K. E.; Ruff, L.; Duarte, M.; Cooper, E.; Hu, L. P.; Katyal, G.; Akhbari, M.; Gilbertson, R. J.; Terhune, C.; Balmus, G.; Jackson, S. P.; Filbin, M. G.; Hill, A.; Patrizi, A.; Dani, N.; Regev, A.; Lehtinen, M. K.; Gilbertson, R. J.
10.1101/2024.04.09.585681 — cancer biology — Posted on 2024-04-09
3442 OmicsFootPrint: a framework to integrate and interpret multi-omics data using circular images and deep neural networks
Tang, X.; Prodduturi, N.; Thompson, K. J.; Weinshilboum, R. M.; O'Sullivan, C. C.; Boughey, J. C.; Tizhoosh, H.; Klee, E. W.; Wang, L.; Goetz, M. P.; Suman, V.; Kalari, K. R.
10.1101/2024.03.21.586001 — bioinformatics — Posted on 2024-04-09
3443 CELEBRIMBOR: Pangenomes from metagenomes
Hellewell, J.; Horsfield, S. T.; von Wachsmann, J.; Gurbich, T.; Finn, R. D.; Iqbal, Z.; Roberts, L. W.; Lees, J.
10.1101/2024.04.05.588231 — bioinformatics — Posted on 2024-04-09
3449 The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain
van Vlimmeren, A. E.; Voleti, R.; Chartier, C. A.; Jiang, Z.; Karandur, D.; Humphries, P. A.; Lo, W.-L.; Shah, N. H.
10.1101/2023.07.10.548257 — biochemistry — Posted on 2024-04-09
3450 Deep Brain Stimulation of Nucleus Basalis of Meynert improves learning in rat model of dementia.
Kumbhare, D.; Rajagopal, M.; Toms, J.; Freelin, A.; Weistroffer, G.; McComb, N.; Karnam, S.; Azghadi, A.; Murnane, K.; Baron, M.; Holloway, K.
10.1101/2024.04.05.588271 — animal behavior and cognition — Posted on 2024-04-09
3451 Vocal complexity in the long calls of Bornean orangutans
Erb, W. M.; Ross, W.; Kazanecki, H.; Setia, T. M.; Madusudhana, S.; Clink, D. J.
10.1101/2023.04.05.535487 — animal behavior and cognition — Posted on 2024-04-09
3452 Blended Genome Exome (BGE) as a Cost Efficient Alternative to Deep Whole Genomes or Arrays
DeFelice, M.; Grimsby, J.; Howrigan, D.; Yuan, K.; Chapman, S. B.; Stevens, C.; DeLuca, S.; Townsend, M.; Buxbaum, J.; Pericak-Vance, M. A.; Qin, S.; Stein, D. J.; Teferra, S.; Xavier, R.; Huang, H.; Martin, A.; Neale, B.
10.1101/2024.04.03.587209 — genomics — Posted on 2024-04-09
3453 Terrestrial 3D Laser Scanning for Ecosystem and Fire Effects Monitoring
Murphy, M. C.; Loudermilk, E. L. L.; Pokswinski, S.; Williams, B.; Link, E.; Lienesch, L.; Douglas, L.; Skowronski, N. S.; Gallagher, M. R.; Maxwell, A.; Snitker, G.; Hawley, C. M.; Wallace, D.; Payne, I.; Yurkiewicz, T.; Sanchez Meador, A.; Anderson, C.; Jackson, M.; Parsons, R.; Floca, M.; Nealey, I.; Altintas, I.; Hiers, J. K.; Wallace, J.
10.1101/2024.04.09.587551 — ecology — Posted on 2024-04-09
3454 Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling
Le Gac, B.; Tournissac, M.; Belzic, E.; Picaud, S.; Dusart, I.; Soula, H.; Li, D.; Charpak, S.; Cauli, B.
10.1101/2024.03.27.586974 — neuroscience — Posted on 2024-04-09
3456 Disruption of Cholinergic Retinal Waves Alters Visual Cortex Development and Function
Burbridge, T. J.; Ratliff, J. M.; Dwivedi, D.; Vrudhula, U.; Alvarado-Huerta, F.; Sjulson, L.; Ibrahim, L. A.; Cheadle, L.; Fishell, G.; Batista-Brito, R.
10.1101/2024.04.05.588143 — neuroscience — Posted on 2024-04-09
3458 Zero-shot animal behavior classification with image-text foundation models
Dussert, G.; Miele, V.; Van Reeth, C.; Delestrade, A.; Dray, S.; Chamaille-Jammes, S.
10.1101/2024.04.05.588078 — ecology — Posted on 2024-04-09
3459 The cellular Notch1 Protein Promotes KSHV reactivation in an Rta-dependent manner.
DeCotiis-Mauro, J.; Han, S. M.; Mello, H.; Goyeneche, C.; Marchesini-Tovar, G.; Jin, L.; Bellofatto, V.; Lukac, D. M.
10.1101/2022.10.21.513206 — microbiology — Posted on 2024-04-09
3460 Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity
Jing, Z.; Galbo, P.; Ovando, L.; Demouth, M.; Welte, S.; Park, R.; Chandran, K.; Wu, Y.; MacCarthy, T.; Zheng, D.; Fooksman, D.
10.1101/2023.02.15.527913 — immunology — Posted on 2024-04-09
3462 Alpha-synuclein aggregates are phosphatase resistant
Choi, S. G.; Prada, D. A. G.; Tittle, T.; Kordower, J. H.; Melki, R.; Killinger, B. A.
10.1101/2023.11.20.567854 — neuroscience — Posted on 2024-04-09
3463 Brain areas for reversible symbolic reference, a potential singularity of the human brain
van Kerkoerle, T.; Pape, L.; Ekramnia, M.; FENG, X.; Tasserie, J.; Dupont, M.; Li, X.; Jarraya, B.; Vanduffel, W.; Dehaene, S.; Dehaene-Lambertz, G.
10.1101/2023.03.04.531109 — neuroscience — Posted on 2024-04-09
3467 Endogenous CD28 drives CAR T cell responses in multiple myeloma
Lieberman, M. M.; Tong, J. H.; Odukwe, N. U.; Chavel, C. A.; Purdon, T. J.; Burchett, R.; Gillard, B. M.; Brackett, C. M.; McGray, A. R.; Bramson, J. L.; Brentjens, R. J.; Lee, K. P.; Olejniczak, S. H.
10.1101/2024.03.21.586084 — cancer biology — Posted on 2024-04-09
3468 Rapid and specific detection of single nanoparticles and viruses in microfluidic laminar flow via confocal fluorescence microscopy
Drori, P.; Mouhadeb, O.; Munoz, G. G. M.; Razvag, Y.; Alcalay, R.; Klocke, P.; Cordes, T.; Zahavy, E.; Lerner, E.
10.1101/2023.12.31.573251 — biophysics — Posted on 2024-04-09
3471 Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3
Rowland, C. E.; Newman, H.; Martin, T. T.; Dods, R.; Bournakas, N.; Wagstaff, J. M.; Lewis, N.; Stanway, S. J.; Balmforth, M.; Kessler, C.; van Rietschoten, K.; Bellini, D.; Roper, D. I.; Lloyd, A. J.; Dowson, C. G.; Skynner, M. J.; Beswick, P.; Dawson, M. J.
10.1101/2024.03.20.581580 — biochemistry — Posted on 2024-04-09
3472 Extreme mitochondrial reduction in a novel group of free-living metamonads.
Williams, S. K.; Jerlstom-Hultqvist, J.; Eglit, Y.; Salas-Leiva, D. E.; Curtis, B.; Orr, R. J. S.; Stairs, C. W.; Atalay, T. N.; MacMillan, N.; Simpson, A. G. B.; Roger, A. J.
10.1101/2023.05.03.539051 — genomics — Posted on 2024-04-09
3474 Bat RNA viruses employ viral RHIMs orchestrating species-specific cell death programs linked to Z-RNA sensing and ZBP1-RIPK3 signaling
Mishra, S.; Jain, D.; Dey, A. A.; Nagaraja, S.; Srivastava, M.; Khatun, O.; Balamurugan, K.; Anand, M.; Tripathi, S.; Ganji, M.; Kesavardhana, S.
10.1101/2023.08.23.554434 — immunology — Posted on 2024-04-09
3475 Unmasking Hidden Systemic Effects of Neurodegenerative Diseases: A Two-Pronged Approach to Biomarker Discovery
Anjo, S. I.; Rosado, M.; Baldeiras, I.; Gomes, A.; Pires, D.; Santa, C.; Pinto, J.; Januario, C.; Santana, I.; Verdelho, A.; Mendonca, A. d.; Castelo-Branco, M.; Manadas, B.
10.1101/2023.11.23.568435 — biochemistry — Posted on 2024-04-09
3476 Harnessing molecular mechanism for precision medicine in dilated cardiomyopathy caused by a mutation in troponin T
Greenberg, L.; Stump, W. T.; Lin, Z. J.; Bredemeyer, A. L.; Blackwell, T.; Hao, X.; Greenberg, A. E.; Garcia, B.; Lavine, K.; Greenberg, M. J.
10.1101/2024.04.05.588306 — biophysics — Posted on 2024-04-09
3477 Oriented Cell Dataset: efficient imagery analyses using angular representation
Kirsten, L. N.; Angonezi, A.; Oliveira, F.; Faccioni, J.; Cassel, C.; Santos de Sousa, D.; Vedovatto, S.; Jung, C.; Lenz, G.
10.1101/2024.04.05.588327 — bioinformatics — Posted on 2024-04-09
3478 Multimodal mechano-microscopy reveals mechanical phenotypes of breast cancer spheroids in three dimensions
Mowla, A.; Hepburn, M. S.; Li, J.; Vahala, D.; Amos, S. E.; Hirvonen, L. M.; Sanderson, R. W.; Wijesinghe, P.; Maher, S.; Choi, Y. S.; Kennedy, B. F.
10.1101/2024.04.05.588260 — bioengineering — Posted on 2024-04-09
3483 Otolith shape variability of labrid fish from Rapa Nui (Easter Island), southeastern Pacific
Castro-Garcia, A.; Delrieu-Trottin, E.; Saenz-Agudelo, P.; Rapu-Edmunds, C.; Plaza, G.; Marquez, F.; Landaeta, M. F.
10.1101/2024.04.05.588230 — zoology — Posted on 2024-04-09
3484 Physiological bias governs neutrophil inflammatory threat perception
Pajonczyk, D.; Pauli, L.; Puent, C.; Sternschulte, M. F.; Fehler, O.; Vogl, T.; Soehnlein, O.; Bermudez, M.; Raabe, C. A.; Rescher, U.
10.1101/2024.04.05.588243 — systems biology — Posted on 2024-04-09
3486 Genome-Wide Association Testing for Haemorrhagic Bowel Syndrome in a Swiss Large White Pig Population
Mehrotra, A.; Leonard, A. S.; Drogemuller, C.; Grahofer, A.; Khayatzadeh, N.; Hofer, A.; Neuenschwander, S.; Pausch, H.
10.1101/2024.04.05.588256 — genomics — Posted on 2024-04-09
3490 Land use effects on soil microbiome composition and traits with consequences for its ecosystem carbon use efficiency
Cole, L.; Goodall, T.; Jehmlich, N.; Griffiths, R. I.; Gleixner, G.; Gubry-Rangin, C.; Malik, A. A.
10.1101/2024.04.05.588235 — ecology — Posted on 2024-04-09
3493 Allelic variations and gene cluster modularity act as non-linear bottlenecks for cholera emergence
Lopez-Perez, M.; Balasubramanian, D.; Crist, C.; Grant, T.-A.; Haro-Moreno, J. M.; Zaragoza-Solas, A.; Almagro-Moreno, S.
10.1101/2022.09.26.509565 — microbiology — Posted on 2024-04-09
3494 A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons
Kelly, D.; Bicker, S.; Winterer, J.; Nanda, P.; Germain, P.-L.; Dieterich, C.; Schratt, G.
10.1101/2024.04.09.588686 — neuroscience — Posted on 2024-04-09
3497 Cytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementia
Ohm, D. T.; Xie, S. X.; Capp, N.; Arezoumandan, S.; Cousins, K. A. Q.; Rascovsky, K.; Wolk, D.; Van Deerlin, V.; Lee, E. B.; McMillan, C.; Irwin, D.
10.1101/2024.04.05.588259 — neuroscience — Posted on 2024-04-09
3498 S1 hydrophobic residues modulate voltage sensing phosphatase enzymatic function and voltage sensing
Rayaprolu, V.; Miettinen, H. M.; Baker, W.; Young, V. C.; Fisher, M.; Mueller, G.; Rankin, W. O.; Kelley, J. J.; Ratzan, W.; Leong, L. M.; Davisson, J. A.; Baker, B. J.; Kohout, S. C.
10.1101/2023.12.27.573443 — biophysics — Posted on 2024-04-09
3503 Activating an invertebrate bistable opsin with the all-trans 6.11 retinal analogue
Rodrigues, M. J.; Tejero, O.; Muhle, J.; Pamula, F. K.; Das, I.; Tsai, C.-J.; Terakita, A.; Sheves, M.; Schertler, G. F. X.
10.1101/2024.04.08.588240 — biochemistry — Posted on 2024-04-09
3505 The human Dicer helicase domain mediates ATP hydrolysis and RNA rearrangement
Ciechanowska, K.; Szczepanska, A.; Szpotkowski, K.; Wojcik, K.; Urbanowicz, A.; Kurzynska-Kokorniak, A.
10.1101/2023.06.28.546842 — molecular biology — Posted on 2024-04-09
3506 Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma
Gordon, K. S.; Perez, C.; Garmilla, A.; Lam, M. S.; Aw, J. J.; Datta, A.; Lauffenburger, D. A.; Pavesi, A.; Birnbaum, M. E.
10.1101/2024.04.04.586240 — immunology — Posted on 2024-04-09
3507 Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers
Gharzeddine, K.; Gonzales Pietro, C.; Malier, M.; Hennot, C.; Grespan, R.; Yamaryo, Y.; Botte, C.; Thomas, F.; Laverriere, M. H.; Girard, E.; Roth, G.; MILLET, A.
10.1101/2024.02.22.581558 — immunology — Posted on 2024-04-09
3508 Cell lipotypes localization in brain by mass spectrometry imaging
Martinez-Gardeazabal, J.; Moreno-Rodriguez, M.; Llorente-Ovejero, A.; Gonzalez de San Roman, E.; Lombardero, L.; Bengoetxea de Tena, I.; Sustacha, J.; Matute, C.; Manuel, I.; Bonifazi, P.; Rodriguez-Puertas, R.
10.1101/2024.02.02.578599 — neuroscience — Posted on 2024-04-09
3509 Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2
Como, C. N.; O'Rourke, R.; Winkler, C.; Mitchell, D.; Tran, L. N.; Lorberbaum, D.; Sussel, L.; Franco, S. J.; Siegenthaler, J. A.
10.1101/2024.04.05.588348 — neuroscience — Posted on 2024-04-09
3512 A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti
Bacot, T.; Haberkorn, C.; Guilliet, J.; Cattel, J.; Kefi, M.; Nadalin, L.; Filee, J.; Boyer, F.; Gaude, T.; Laporte, F.; Tutagata, J.; Vontas, J.; Dusfour, I.; Bonneville, J.-M.; David, J.-P.
10.1101/2024.04.03.587871 — evolutionary biology — Posted on 2024-04-09
3513 ER-associated degradation by Doa10 restrains mitophagy in yeast
Eiyama, A.; Onishi, M.; Omi, Y.; Nakatsukasa, K.; Okamoto, K.
10.1101/2024.04.08.588568 — cell biology — Posted on 2024-04-09
3514 Anchor-Enhanced Bead Design for Reduced Oligonucleotide Synthesis Errors in Single-cell sequencing
Sun, J.; Philpott, M.; Loi, D.; Hoffman, G.; Robson, J.; Mehta, N.; Calcutt, E.; Gamble, V.; Brown, T.; Brown, T.; Oppermann, U.; Cribbs, A. P.
10.1101/2024.04.08.587145 — molecular biology — Posted on 2024-04-09
3517 Microstructural asymmetry in the human cortex
Wan, B.; Saberi, A.; Paquola, C.; Schaare, H. L.; Hettwer, M. D.; Royer, J.; John, A.; Dorfschmidt, L.; Bayrak, S.; Bethlehem, R. A. I.; Eickhoff, S. B.; Bernhardt, B. C.; Valk, S. L.
10.1101/2024.04.08.587194 — neuroscience — Posted on 2024-04-09
3518 A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons
Moissidis, M.; Abbasova, L.; Alis, R.; Bernard, C.; Dominguez, Y.; Qin, S.; Kelly, A.; Oozeer, F.; Modol, L.; Hamid, F.; Lavender, P.; Flames, N.; Marin, O.
10.1101/2024.04.08.588555 — neuroscience — Posted on 2024-04-09
3519 Identification and characterization of a synaptic active zone assembly protein
Luetzkendorf, J.; Matkovic, T.; Goetz, T.; Liu, S.; Ghelani, T.; Maglione, M.; Grieger, M.; Putignano, S.; Gao, L.; Gimber, N.; Schmoranzer, J.; Stawrakakis, A.; Walter, A. M.; Heine, M.; Wahl, M.; Mielke, T.; Liu, F.; Sigrist, S. J.
10.1101/2024.04.08.588536 — neuroscience — Posted on 2024-04-09
3520 Maturation-informed synthetic Magnetic Resonance Images of the Developing Human Fetal Brain
Lajous, H.; le Boeuf Flo, A.; Gordaliza, P. M.; Esteban, O.; Marques, F.; Dunet, V.; Koob, M.; Cuadra, M. B.
10.1101/2024.04.08.588566 — bioinformatics — Posted on 2024-04-09
3523 SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus
Wu, D.; Yang, C.; Yao, Y.; Ma, D.; Lin, H.; Hao, L.; Xin, W.; Ye, K.; Sun, M.; Hu, Y.; Yang, Y.; Zhuang, Z.
10.1101/2023.12.19.572357 — pharmacology and toxicology — Posted on 2024-04-09
3527 Exosomes are vehicles for the stress-regulated secretion of histones
Singh, B.; Sundbom, M. F.; Muthukrishnan, U.; Natarajan, B.; Stransky, S.; Nordin, J. Z.; Wiklander, O. P. B.; Sandblad, L.; Sidoli, S.; EL Andaloussi, S.; Haney, M.; Gilthorpe, J. D.
10.1101/2024.04.08.588575 — cell biology — Posted on 2024-04-08
3529 Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia
Delfinis, L. J.; Ogilvie, L. M.; Khajehzadehshoushtar, S.; Gandhi, S.; Garibotti, M. C.; Thuhan, A. K.; Matuszewska, K.; Pereira, M.; Jones, R. G.; Cheng, A. J.; Hawke, T. J.; Greene, N. P.; Murach, K.; Simpson, J. A.; Petrik, J.; Perry, C.
10.1101/2024.04.08.588639 — physiology — Posted on 2024-04-08
3530 Anchor-Enhanced Bead Design for Reduced Oligonucleotide Synthesis Errors in Single-cell sequencing
Cribbs, A. P.; Sun, J.; Philpott, M.; Loi, D.; Hoffman, G.; Robson, J.; Mehta, N.; Calcutt, E.; Gamble, V.; Brown, T.; Brown, T.; Oppermann, U.
10.1101/2024.04.08.587145 — molecular biology — Posted on 2024-04-08
3534 Does the host drive Wolbachia gene expression?
Papaleo, S.; Panelli, S.; Bitar, I.; Sterzi, L.; Nodari, R.; Comandatore, F.
10.1101/2024.04.08.588587 — microbiology — Posted on 2024-04-08
3536 Examining Cognitive Performance in Mice using the Open-Source Operant Feeding Device FED3
Murdaugh, L. B.; Brown, B.; Chen, C.-H.; Miliano, C.; Dong, Y.; Shepard, S.; Putnam, J. W.; Faunce, C. L.; Natividad, L. A.; Vijayan, S.; Gregus, A. M.; Buczynski, M.
10.1101/2024.04.04.588157 — neuroscience — Posted on 2024-04-08
3541 Visualization and quantification of coral reef soundscapes using CoralSoundExplorer software
Minier, L.; Rouch, J.; Sabbagh, B.; Bertucci, F.; Parmentier, E.; Lecchini, D.; Sebe, F.; Mathevon, N.; Emonet, R.
10.1101/2024.04.05.588225 — ecology — Posted on 2024-04-08
3542 Swi4-dependent SWI4 transcription couples cell size to cell cycle commitment
Goswami, P.; Ghimire, A.; Coffin, C.; Cheng, J.; Coulombe-Huntington, J.; Ghazal, G.; Thattikota, Y.; Tyers, M.; Tollis, S.; Royer, C. A.
10.1101/2023.11.29.569332 — cell biology — Posted on 2024-04-08
3545 Phosphate starvation stops bacteria digesting algal fucan that sequesters carbon
Xu, Y.; Schultz-Johansen, M.; Yao, H.; Wilkie, I.; Klau, L. J.; Chen, Y.; Orellana, L. H.; Aachmann, F. L.; Farhan, M.; Gu, B.; Reintjes, G.; Vidal-Melgosa, S.; Qiao, D.; Cao, Y.; Hehemann, J.-H.
10.1101/2024.04.07.588495 — microbiology — Posted on 2024-04-08
3548 Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability
Abbott, K. L.; Ali, A.; Reinfeld, B. I.; Deik, A. A. I.; Subudhi, S.; Landis, M. D.; Hongo, R. A.; Young, K. L.; Kunchok, T.; Nabel, C. S.; Crowder, K. D.; Kent, J. R.; Madariaga, M. L. L.; Jain, R. K.; Beckermann, K. E.; Lewis, C. A.; Clish, C. B.; Muir, A.; Rathmell, W. K.; Rathmell, J. C.; Vander Heiden, M. G.
10.1101/2023.12.24.573250 — cancer biology — Posted on 2024-04-08
3549 α-Synuclein oligomers form by secondary nucleation
Xu, C. K.; Meisl, G.; Andrzejewska, E.; Krainer, G.; Dear, A. J.; Cruz, M. C.; Turi, S.; Jacquat, R.; Arter, W. E.; Vendruscolo, M.; Linse, S.; Knowles, T. P.
10.1101/2023.05.28.542651 — biophysics — Posted on 2024-04-08
3551 Medicinal chemistry lens on patent data in SureChEMBL
Gadiya, Y.; Shetty, S.; Hofmann-Apitius, M.; Gribbon, P.; Zaliani, A.
10.1101/2023.11.27.568822 — bioinformatics — Posted on 2024-04-08
3552 DNA targeting by compact Cas9d and its resurrected ancestor
Fregoso Ocampo, R.; Bravo, J. P.; Dangerfield, T. L.; Noceda, I.; Jirde, S.; Alexander, L. M.; Das, A.; Nielsen, S.; Johnson, K. A.; Brown, C. T.; Butterfield, C. N.; Goltsman, D. S.; Taylor, D. W.
10.1101/2024.04.08.588528 — biochemistry — Posted on 2024-04-08
3553 Multimodal hierarchical classification of CITE-seq data delineates immune cell states across lineages and tissues
Caron, D. P.; Specht, W. L.; Chen, D.; Wells, S. B.; Szabo, P. A.; Jensen, I. J.; Farber, D. L.; Sims, P. A.
10.1101/2023.07.06.547944 — genomics — Posted on 2024-04-08
3554 Gene-environment correlation: The role of family environment in academic development
Zhou, Q.; Gidziela, A.; Allegrini, A. G.; Cheesman, R.; Wertz, J.; Maxwell, J.; Plomin, R.; Rimfeld, K.; Malanchini, M.
10.1101/2024.01.05.574339 — genetics — Posted on 2024-04-08
3558 STRIPAK controls cell-cell communication by promoting cytoneme biogenesis through the membrane-sculpting function of Slik.
Rambaud, B.; Joseph, M.; Tsai, F.-C.; De Jamblinne, C. V.; Del Guidice, E.; Sabelli, R.; Bassereau, P.; Hipfner, D. R.; Carreno, S.
10.1101/2024.03.04.583182 — cell biology — Posted on 2024-04-08
3559 E. coli division machinery drives cocci development inside host cells
Pokhrel, A.; Costas, A.; Pittorino, M.; Duggin, I. G.; Söderström, B.
10.1101/2024.04.08.588611 — microbiology — Posted on 2024-04-08
3560 Meta-transcriptomic analysis of companion animal infectomes reveals their diversity and potential roles in animal and human disease
Wu, W.-C.; Pan, Y.-F.; Zhou, W.-D.; Liao, Y.-Q.; Peng, M.-W.; Luo, G.-Y.; Xin, G.-Y.; Peng, Y.-N.; An, T.; Li, B.; Luo, H.; Barrs, V. R.; Beatty, J. A.; Holmes, E. C.; Zhao, W.; Shu, Y.
10.1101/2024.04.07.588491 — microbiology — Posted on 2024-04-08
3561 Identification of Determinants that Allow Maintenance of High-Level Fluoroquinolone Resistance in Acinetobacter baumannii
Hamami, E.; Huo, W.; Castaneda, A.; Bai, J.; Syal, S.; Ortiz-Marquez, J. C.; van Opijnen, T.; Geisinger, E.; Isberg, R. R.
10.1101/2023.10.03.560562 — microbiology — Posted on 2024-04-08
3563 Presence of phage-plasmids in multiple serovars of Salmonella enterica
Nair, S.; Barker, C. R.; Bird, M.; Greig, D. R.; Collins, C.; Painset, A.; Chattaway, M.; Pickard, D.; Larkin, L.; Gharbia, S.; Didelot, X.; Ribeca, P.
10.1101/2024.02.02.574330 — microbiology — Posted on 2024-04-08
3566 Human adolescent brain similarity development is different for paralimbic versus neocortical zones
Dorfschmidt, L.; Vasa, F.; White, S. R.; Garcia, R. R.; Kitzbichler, M. G.; Alexander-Bloch, A.; Cieslak, M.; Mehta, K.; Satterthwaite, T. D.; the NSPN Consortium, ; Bethlehem, R. A. I.; Seidlitz, J.; Vertes, P.; Bullmore, E. T.
10.1101/2023.09.17.558126 — neuroscience — Posted on 2024-04-08
3570 Nerve injury inhibits Oprd1 and Cnr1 transcription through REST in primary sensory neurons
Subedi, A.; Tiwari, A.; Etemad, A. F.; Huang, Y.; Chatterjee, B.; McLeod, S. L.; Lu, Y.; Gonzalez, D.; Ghosh, K.; Singh, S. K.; Ruiz Echartea, M. E.; Grimm, S. L.; Coarfa, C.; Pan, H.-L.; Majumder, S.
10.1101/2024.02.17.579842 — neuroscience — Posted on 2024-04-08
3571 Measuring the burden of hundreds of BioBricks defines an evolutionary limit on constructability in synthetic biology
Radde, N.; Mortensen, G. A.; Bhat, D.; Shah, S.; Clements, J. J.; Leonard, S. P.; McGuffie, M. J.; Mishler, D. M.; Barrick, J. E.
10.1101/2024.04.08.588465 — synthetic biology — Posted on 2024-04-08
3573 DNA methylation modulates transcriptional noise in response to elevated pCO2 in the eastern oyster (Crassostrea virginica)
Venkataraman, Y. R.; Huffmyer, A. S.; White, S. J.; Downey-Wall, A.; Ashey, J.; Becker, D. M.; Bengtsson, Z.; Putnam, H. M.; Strand, E.; Rodriguez-Casariego, J. A.; Wanamaker, S. A.; Lotterhos, K. E.; Roberts, S.
10.1101/2024.04.04.588108 — physiology — Posted on 2024-04-08
3574 Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma
Strijker, J. G. M.; Pascual-Pasto, G.; Kalmeijer, Y. J.; Kalaitsidou, E.; Zhao, C.; McIntyre, B.; Matlaga, S.; Visser, L. L.; Barisa, M.; Himsworth, C.; Shah, R.; Muller, H.; Schild, L. G.; Hains, P. G.; Zhong, Q.; Reddel, R.; Robinson, P.; Catena, X.; Soengas, M. S.; Margaritis, T.; Dekker, F. J.; Anderson, J.; Molenaar, J. J.; Bosse, K. R.; Wu, W.; Wienke, J.
10.1101/2024.04.05.588098 — cancer biology — Posted on 2024-04-08
3576 Stepwise Stiffening/Softening of and Cell Recovery from Reversibly Formulated Hydrogel Double Networks
Kopyeva, I.; Goldner, E. C.; Hoye, J. W.; Yang, S.; Regier, M. C.; Vera, K. R.; Bretherton, R. C.; DeForest, C. A.
10.1101/2024.04.04.588191 — bioengineering — Posted on 2024-04-08
3578 The resting state of the human T-cell receptor-CD3 complex
Notti, R. Q.; Yi, F.; Heissel, S.; Bush, M. W.; Molina, H.; Molvi, Z.; Klebanoff, C. A.; Walz, T.
10.1101/2023.08.22.554360 — biochemistry — Posted on 2024-04-08
3579 Retrotransposon expression is upregulated by aging and suppressed during regeneration of the limb in the axolotl (Ambystoma mexicanum)
Ruiz-Perez, S.; Torres-Arciga, K.; Samano-Salazar, C. G.; Ocampo-Cervantes, J. A.; Cervera, A.; Castro-Hernandez, C.; Soto-Reyes, E.; Alcaraz, N.; Gonzalez-Barrios, R.
10.1101/2024.04.04.588033 — genomics — Posted on 2024-04-08
3583 Growth directions and stiffness across cell layers determine whether tissues stay smooth or buckle
Yadav, A. S.; Hong, L.; Klees, P. M.; Kiss, A.; Petit, M.; He, X.; Barrios, I. M.; Heeney, M.; Galang, A. M. D.; Smith, R. S.; Boudaoud, A.; Roeder, A. H. K.
10.1101/2023.07.22.549953 — developmental biology — Posted on 2024-04-08
3586 Chemical tools to define and manipulate interferon-inducible Ubl protease USP18
Davis, G. J.; Omole, A. O.; Jung, Y.; Rut, W.; Holewinski, R.; Suazo, K. F.; Kim, H.-R.; Yang, M.; Andresson, T.; Drag, M.; Yoo, E.
10.1101/2024.04.08.588544 — molecular biology — Posted on 2024-04-08
3590 STING promotes homeostatic maintenance of tissues and confers longevity with aging
Hopkins, J. W.; Sulka, K. B.; Sawden, M.; Carroll, K. A.; Brown, R. D.; Bunnell, S. C.; Poltorak, A.; Alcaide, P.; Tai, A.; Reed, E. R.; Sharma, S.
10.1101/2024.04.04.588107 — immunology — Posted on 2024-04-08
3591 Comparative specialization of intrinsic cardiac neurons in humans, mice, and pigs
Tompkins, J. D.; Hoover, D. B.; Havton, L. A.; Patel, J. C.; Cho, Y.; Smith, E. H.; Biscola, N. P.; Ajijola, O. A.; Kalyanam, S.; Ardell, J. L.
10.1101/2024.04.04.588174 — neuroscience — Posted on 2024-04-08
3592 Corticospinal and corticoreticulospinal projections benefit motor behaviors in chronic stroke
Taga, M.; Hong, Y. N. G.; Charalambous, C. C.; Raju, S.; Hayes, L.; Lin, J.; Zhang, Y.; Shao, Y.; Houston, M.; Zhang, Y.; Mazzoni, P.; Roh, J.; Schambra, H.
10.1101/2024.04.04.588112 — neuroscience — Posted on 2024-04-08
3595 Enhanced behavioural and neural sensitivity to punishments in chronic pain and fatigue
Mancini, F.; Mahajan, P.; Guttesen, A. a. V.; Onysk, J.; Scholtes, I.; Shenker, N.; Lee, M.; Seymour, B.
10.1101/2024.04.04.588151 — neuroscience — Posted on 2024-04-08
3596 Parallel Labeled-Line Organization of Sympathetic Outflow for Selective Organ Regulation in Mice
Harima, Y.; Tsurutani, M.; Uchida, S.; Inada, k.; Hagihara, M.; Irie, S.; Shigeta, M.; Abe, T.; U. Inoue, Y.; Inoue, T.; Miyamichi, K.
10.1101/2024.04.04.588164 — neuroscience — Posted on 2024-04-08
3597 Microdroplet screening rapidly profiles a biocatalyst to enable its AI-assisted engineering
Gantz, M.; Mathis, S.; Nintzel, F.; Zurek, P. J.; Knaus, T.; Patel, E.; Boros, D.; Weberling, F.-M.; Kenneth, M. R. A.; Klein, O. J.; Medcalf, E. J.; Moss, J.; Herger, M.; Kaminski, T. S.; Mutti, F.; Lio, P.; Hollfelder, F.
10.1101/2024.04.08.588565 — synthetic biology — Posted on 2024-04-08
3598 SBT5.2s are the major active extracellular subtilases processing IgG antibody 2F5 in the Nicotiana benthamiana apoplast
Beritza, K.; Buscaill, P.; Song, S.-J.; Jutras, P. V.; Huang, J.; Mach, L.; Dong, S.; van der Hoorn, R.
10.1101/2024.04.07.588497 — plant biology — Posted on 2024-04-08
3600 The Transcription Factor OsNAC5 Mediates Cadmium Stress Response and Accumulation in Rice
Hu, S.; Chen, J.; Wang, H.; Ji, E.; Su, X.; Zhu, M.; Xiang, X.; Gong, L.; Zhou, Q.; Xiao, X.; Wu, G.
10.1101/2024.04.07.588483 — plant biology — Posted on 2024-04-08
3602 Modulation of photosystem II heterogeneity and stomatal functioning contribute to sustaining photochemistry and photoprotection in mangroves exposed to a cold wave
Valiaparambil Sebastian, J. S.; Mathur, S.; Elsheery, N.; Yan, L.; Jajoo, A.; Short, A.; Wee, A.; Aritsara, A.; Kajita, T.; Cao, K.-F.
10.1101/2024.04.08.588527 — plant biology — Posted on 2024-04-08
3604 Immune regulators EDS1 and PAD4 constrain ADR1-dependent disease resistance in rice
Fernandes, J.; Wang, J.; Su, R.; Lee, T.; Zheng, Z.; Perin, S.; Cesari, S.; Jalilian, A.; Sciallano, C.; Szurek, B.; Cui, H.; Kroj, T.; Parker, J. E.
10.1101/2024.04.08.588512 — plant biology — Posted on 2024-04-08
3606 Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19
Lu, Y.; Yang, Q.; Ran, T.; Zhang, G.; Li, W.; Zhou, P.; Tang, J.; Dai, M.; Zhong, J.; Chen, H.; He, P.; Zhou, A.; Xue, B.; Chen, J.; Zhang, J.; Yang, S.; Wu, K.; Wu, X.; Tang, M.; Zhang, W. K.; Guo, D.; Chen, X.; Chen, H.; Shang, J.
10.1101/2024.04.03.587743 — microbiology — Posted on 2024-04-08
3610 Staining and resin embedding of whole Daphnia samples for micro-CT imaging enabling 3D visualization of cells, tissues, and organs of various thicknesses
Ngu, M. S.; Vanselow, D. J.; Saint-Fort, R. A.; Sugarman, A. L.; Zaino, C. R.; Yakovlev, M. A.; Cheng, K. C.; Ang, K. C.
10.1101/2023.05.21.541654 — zoology — Posted on 2024-04-08
3611 Comparative metagenomic profiling of seed-borne microbiomes in a landrace and a hybrid maize variety
Henaut-Jacobs, S.; Cyriaco, B. E. B.; Pedrosa-Silva, F.; Olivares, F. L.; Venancio, T. M.
10.1101/2024.04.04.588073 — plant biology — Posted on 2024-04-08
3612 PPARG in osteocytes controls cell bioenergetics and systemic energy metabolism independently of sclerostin levels in circulation
Baroi, S.; Czernik, P. J.; Khan, M.; Letson, J.; Crowe, E.; Chougule, A.; Griffin, P. R.; Rosen, C. J.; Lecka-Czernik, B.
10.1101/2024.04.04.588029 — physiology — Posted on 2024-04-08
3621 Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist
Maruyama, Y.; Ohsawa, Y.; Suzuki, T.; Yamauchi, Y.; Ohno, K.; Inoue, H.; Yamamoto, A.; Hayashi, M.; Okuhara, Y.; Muramatsu, W.; Namiki, K.; Miyauchi, M.; Miyao, T.; Hagiwara, N.; Ishikawa, T.; Horie, K.; Hayama, M.; Akiyama, N.; Hirokawa, T.; Akiyama, T.
10.1101/2023.05.08.539826 — pharmacology and toxicology — Posted on 2024-04-08
3622 12/15-Lipoxygenases mediate neuropathic-like pain hypersensitivity in female mice
Brown, B.; Chen, I.; Miliano, C.; Murdaugh, L. B.; Dong, Y.; Eddinger, K. A.; Yaksh, T. L.; Burton, M. D.; Buczynski, M.; Gregus, A. M.
10.1101/2024.04.04.588153 — pharmacology and toxicology — Posted on 2024-04-08
3625 6-Phosphogluconolactonase is critical for the efficient functioning of the pentose phosphate pathway
Phegnon, L.; Perochon, J.; Uttenweiler-Joseph, S.; Cahoreau, E.; Millard, P.; Letisse, F.
10.1101/2023.11.29.569206 — biochemistry — Posted on 2024-04-08
3628 The Role of Vitamin D in Emiliania huxleyi: A Microalgal Perspective on UV Exposure
Eliason, O.; Malitsky, S.; Panizel, I.; Feldmesser, E.; Sperfeld, M.; Segev, E.
10.1101/2023.09.21.558789 — microbiology — Posted on 2024-04-08
3629 Reducing the Bacterial Lag Phase Through Methylated Compounds: Insights from Algal-Bacterial Interactions
Sperfeld, M.; Narvaez-Barragan, D. A.; Malitsky, S.; Frydman, V.; Yuda, L.; Rocha, J.; Segev, E.
10.1101/2023.06.06.543872 — microbiology — Posted on 2024-04-08
3632 Proliferation of SH-SY5Y neuroblastoma cells on confined spaces
Kalwarczyk, E.; Lukasiak, A.; Woznica, D.; Switlik, W.; Anchimowicz, J.; Zielonka, P.; Jakiela, S.
10.1101/2024.02.05.578902 — biophysics — Posted on 2024-04-08
3636 Algal Exudates Promote Conjugation in Marine Roseobacters
Duchin Rapp, Y.; Yuda, L.; Matsliyah, D.; Kublanov, I. V.; Segev, E.
10.1101/2023.11.14.567099 — microbiology — Posted on 2024-04-08
3637 Dystrophin deficiency impairs cell junction formation during embryonic myogenesis
Mozin, E.; Massourides, E.; Mournetas, V.; Lievre, C.; Bourdon, A.; Jackson, D. L.; Packer, J. S.; Seong, J.; Trapnell, C.; Le Guiner, C.; Adjali, O.; Pinset, C.; Mack, D. L.; Dupont, J.-B.
10.1101/2023.12.05.569919 — pathology — Posted on 2024-04-08
3638 Comparative genomics of macaques and integrated insights into genetic variation and population history
Zhang, S.; Xu, N.; Fu, L.; Yang, X.; Li, Y.; Yang, Z.; Feng, Y.; Ma, K.; Jiang, X.; Han, J.; Hu, R.; Zhang, L.; Gennaro, L. d.; Ryabov, F.; Meng, D.; He, Y.; Wu, D.; Yang, C.; Paparella, A.; Mao, Y.; Bian, X.; Lu, Y.; Antonacci, F.; Ventura, M.; Shepelev, V. A.; Miga, K. H.; Alexandrov, I. A.; Logsdon, G. A.; Phillippy, A. M.; Su, B.; Zhang, G.; Eichler, E. E.; Lu, Q.; Shi, Y.; Sun, Q.; Mao, Y.
10.1101/2024.04.07.588379 — genomics — Posted on 2024-04-08
3639 An Improved Chromosome-scale Genome Assembly and Population Genetics resource for Populus tremula.
Robinson, K. M.; Schiffthaler, B.; Liu, H.; Westman, S. M.; Rendon-Anaya, M.; Ahlgren Kalman, T.; Kumar, V.; Canovi, C.; Bernhardsson, C.; Delhomme, N.; Jenkins, J.; Wang, J.; Mähler, N.; Richau, K. H.; Stokes, V.; A'Hara, S.; Cottrell, J.; Coeck, K.; Diels, T.; Vandepoele, K.; Mannapperuma, C.; Park, E.-J.; Plaisance, S.; Jansson, S.; Ingvarsson, P. K.; Street, N. R.
10.1101/805614 — genomics — Posted on 2024-04-08
3640 Evolutionary computing to assemble standing genetic diversity and achieve long-term genetic gain
Villiers, K.; Voss-Fels, K. P.; Dinglasan, E.; Jacobs, B.; Hickey, L.; Hayes, B. J.
10.1101/2023.05.05.539510 — genetics — Posted on 2024-04-08
3641 Accumbens Nitrergic Interneurons Drive the Cell Type-Specific Synaptic Plasticity Required for Cue-Induced Cocaine Seeking
Denton, A. R.; Clarke, R. E.; Green, L. M.; Carroll-Deaton, J.; Westphal, A. M.; Seimsen, B. M.; Brock, A. G.; Lavine, J.; Taniguchi, M.; McGinty, J. F.; Smith, A. C.; Garcia-Keller, C.; Otis, J. M.; Scofield, M. D.
10.1101/2024.04.05.587610 — neuroscience — Posted on 2024-04-08
3643 Transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters
Dmitrieva, N.; Gholami, S.; Alleva, C.; Carloni, P.; Alfonso-Prieto, M.; Fahlke, C.
10.1101/2024.02.07.579339 — biophysics — Posted on 2024-04-07
3646 Dark side of the honeymoon: reconstructing the Asian x European rose breeding history through the lens of genomics
Leroy, T.; Albert, E.; Thouroude, T.; Baudino, S.; Caissard, J.-C.; Chastellier, A.; Chameau, J.; Jeauffre, J.; Loubert, T.; Paramita, S. N.; Pernet, A.; Soufflet-Freslon, V.; Oghina-Pavie, C.; Foucher, F.; Oyant, L. H.-S.; Clotault, J.
10.1101/2023.06.22.546162 — genomics — Posted on 2024-04-07
3647 An amplicon panel for high-throughput and low-cost genotyping of Pacific oyster
Sutherland, B. J. G.; Thompson, N. F.; Surry, L. B.; Gujjula, K. R.; Carrasco, C. D.; Chadaram, S.; Lunda, S. L.; Langdon, C. J.; Chan, A. M.; Suttle, C. A.; Green, T. J.
10.1101/2023.08.26.554329 — genetics — Posted on 2024-04-07
3648 The genomic landscape of adaptation to a new host plant
Steward, R. A.; Nilsson, K. J.; Ortega Gimenez, J.; Nolen, Z. J.; Yan, C.; Huang, Y.; Ayala Lopez, J.; Runemark, A.
10.1101/2023.04.17.537225 — evolutionary biology — Posted on 2024-04-08
3650 The Lateral/Caudal Ganglionic Eminence Makes a Limited Contribution to Cortical Oligodendrocytes
Li, J.; Yang, F.; Tian, Y.; Wang, Z.; Qi, D.; Yang, Z.; Song, J.; Ding, J.; Wang, X.; Zhang, z.
10.1101/2023.12.01.569674 — developmental biology — Posted on 2024-04-07
3652 Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers
Krasik, S. V.; Bryushkova, E. A.; Sharonov, G. V.; Myalik, D. S.; Shurganova, E. V.; Komarov, D. V.; Shagina, I. A.; Shpudeiko, P. S.; Turchaninova, M. A.; Vakhitova, M. T.; Samoylenko, I. V.; Marinov, D. T.; Demidov, L. V.; Zagainov, V. E.; Chudakov, D. M.; Serebrovskaya, E. O.
10.1101/2023.04.16.537028 — immunology — Posted on 2024-04-07
3657 The Alzheimer's Amyloid beta peptide forms biomolecular condensates that trigger amyloid aggregation
Sneideriene, G.; Gonzalez Diaz, A.; Adhikari, S. D.; Wei, J.; Michaels, T.; Sneideris, T.; Linse, S.; Vendruscolo, M.; Garai, K.; Knowles, T.
10.1101/2024.01.14.575549 — biophysics — Posted on 2024-04-07
3658 Alpha-synuclein oligomers displace monomeric alpha-synuclein from lipid membranes
Sneideriene, G.; Czekalska, M. A.; Xu, C. K.; Jayaram, A.; Krainer, G.; Arter, W. E.; Peter, Q.; Castellana-Cruz, M.; Saar, K. L.; Levin, A.; Mueller, T.; Fiedler, S.; Devenish, S. R. A.; Fiegler, H.; Kumita, J. R.; Knowles, T.
10.1101/2023.03.21.533646 — biophysics — Posted on 2024-04-07
3659 SmCCNet 2.0: A Comprehensive Tool for Multi-omics Network Inference
Liu, W.; Vu, T.; Konigsberg, I. R.; Pratte, K. A.; Zhuang, Y.; Kechris, K. J.
10.1101/2023.11.20.567893 — bioinformatics — Posted on 2024-04-07
3660 The distribution of Apis laboriosa revisited: range extensions and biogeographic affinities
Otis, G. W.; Huang, M.-J.; Kitnya, N.; Sheikh, U. A. A.; Faiz, A. u. A.; Phung, C. H.; Warrit, N.; Peng, Y.-Q.; Zhou, X.; Oo, H. M.; Acharya, N.; Devkota, K.
10.1101/2024.04.04.588077 — ecology — Posted on 2024-04-07
3662 A tug-of-war between the NuRD and SWI/SNF chromatin remodelers regulates the coordinated activation of Epithelial-Mesenchymal Transition and inflammation in oral cancer.
Stabile, R.; Tucci, F. A.; Verhagen, M. P.; Embregts, C.; Van denBosh, T. P. P.; Joosten, R.; de HErdt, M. J.; van der Steen, B.; Nigg, A. L.; Koljenovic, S.; Hardillo, J. A.; Verrijzer, C. P.; Biddle, A.; Baatenburg de Jong, R. J.; Leenen, P. J.; Fodde, R.
10.1101/2024.04.05.588102 — cancer biology — Posted on 2024-04-07
3663 Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis
Sarkar, A.; Dhar, S.; Bera, S.; Chakravarti, M.; Verma, A.; Prasad, P.; Sultana, J.; Das, J.; Saha, A.; Bhuniya, A.; Guha, I.; Dasgupta, S.; Roy, S. S.; Banerjee, S.; Roy, S.; Bhar, D.; Storkus, W. J.; Baral, R.; Datta, D.; Bose, A.
10.1101/2024.04.04.588206 — cancer biology — Posted on 2024-04-07
3667 Alleviating cell-free DNA sequencing biases with optimal transport
Passemiers, A.; Jatsenko, T.; Vanderstichele, A.; Busschaert, P.; Coosemans, A.; Timmerman, D.; Lambrechts, D.; Raimondi, D.; Vermeesch, J. R.; Moreau, Y.
10.1101/2024.04.04.588204 — bioinformatics — Posted on 2024-04-07
3670 Podocyte exopher-formation as a novel pathomechanism in membranous nephropathy
Lahme, K.; Sachs, W.; Froembling, S.; Brehler, M.; Loreth, D.; Surmann, K.; Gaffling, S.; Wedekind, U.; Boettcher-Dierks, V.; Adler, M. R.; Saez, P. J.; Conze, C.; Thuenauer, R.; Skuza, S.; Neitzel, K.; Zielinski, S.; Brand, J.; Bonn, S.; Voelker, U.; Zimmermann, M.; Wiech, T.; Meyer, T. N.; Fester, L.; Meyer-Schwesinger, C.
10.1101/2024.04.04.588146 — cell biology — Posted on 2024-04-07
3671 Cell and Transcriptomic Diversity of Infrapatellar Fat Pad during Knee Osteoarthritis
Peters, H.; Potla, P.; Rockel, J. S.; Tockovska, T.; Pastrello, C.; Jurisica, I.; Santos, K. D.; Vohra, S.; Lively, S.; Perry, K.; Looby, N.; Li, S. H.; Chandran, V.; Hueniken, K.; Kaur, P.; Perruccio, A. V.; Mahomed, N. N.; Rampersaud, Y. R.; Syed, K. A.; Gracey, E.; Krawetz, R.; Buechler, M. B.; Gandhi, R.; Kapoor, M.
10.1101/2024.04.04.588106 — cell biology — Posted on 2024-04-07
3673 CTCF mutation at R567 causes developmental disorders via 3D genome rearrangement and abnormal neurodevelopment
Zhang, J.; Hu, G.; Lu, Y.; Ren, H.; Huang, Y.; Wen, Y.; Ji, B.; Wang, D.; Wang, H.; Liu, H.; Ma, N.; Pan, G.; Qu, Y.; Zhang, W.; Miao, Z.; Yao, H.
10.1101/2024.04.07.588438 — molecular biology — Posted on 2024-04-07
3676 Modular structure of RNA 3' processing condensates involving the Arabidopsis RNA binding protein FCA
Jang, G.-J.; Payne-Dwyer, A. L.; Maple, R.; Wu, Z.; Liu, F.; Lopez, S. G.; Leake, M. C.; Dean, C.
10.1101/2024.04.06.588283 — molecular biology — Posted on 2024-04-07
3678 Spatial proteomics identifies a novel CRTC-dependent viral sensing pathway that stimulates production of Interleukin-11
Ravenhill, B. J.; Oliveira, M.; Wood, G.; Di, Y.; Davies, C.; Lu, Y.; Antrobus, R.; Elliott, G.; Irigoyen, N.; Hughes, D. J.; Lyons, P.; Chung, B. Y.; Borner, G.; Weekes, M. P.
10.1101/2024.04.04.588067 — immunology — Posted on 2024-04-07
3680 Modeling relaxation experiments with a mechanistic model of gene expression
Estavoyer, M.; Dufeu, M.; Ranson, G.; Lefort, S.; Voeltzel, T.; Maguer-Satta, V.; Gandrillon, O.; Lepoutre, T.
10.1101/2024.04.04.588028 — systems biology — Posted on 2024-04-07
3681 Positive allosteric modulation of a GPCR ternary complex
Burger, W.; Draper-Joyce, C.; Valant, C.; Christopoulos, A.; Thal, D. M.
10.1101/2024.04.04.588200 — pharmacology and toxicology — Posted on 2024-04-07
3682 The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges
Ho, J. J.; Cheng, E.; Wong, C. J.; St-Germain, J. R.; Dunham, W. H.; Raught, B.; Gingras, A.-C.; Brown, G. W.
10.1101/2024.04.07.588476 — molecular biology — Posted on 2024-04-07
3686 Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics
Carlson, R. J.; Patten, J. J.; Stefanakis, G.; Soong, B. Y.; Radhakrishnan, A.; Singh, A.; Thakur, N.; Amarasinghe, G. K.; Hacohen, N.; Basler, C. F.; Leung, D.; Uhler, C.; Davey, R. A.; Blainey, P. C.
10.1101/2024.04.06.588168 — microbiology — Posted on 2024-04-07
3687 Plant Development Drives Dynamic Shifts in the Root Compartment Microbiomes of Wild and Domesticated Finger Millet Cultivars
Dadi, F. A.; Muthusamy, S.; Ghosh, S.; Muleta, D.; Tesfaye, K.; Assefa, F.; Xu, J.; Ghadamgahi, F.; Ortiz, R.; Vetukuri, R. R.
10.1101/2024.04.07.588467 — microbiology — Posted on 2024-04-07
3688 Epitope-anchored contrastive transfer learning for paired CD8+ T cell receptor-antigen recognition
Zhang, Y.; Wang, Z.; Jiang, Y.; Littler, D. R.; Gerstein, M.; Purcell, A. W.; Rossjohn, J.; Ou, H.-Y.; Song, J.
10.1101/2024.04.05.588255 — bioinformatics — Posted on 2024-04-07
3691 An active RNA transport mechanism into plant vacuoles
Floyd, B. E.; Wong, M. M.; Liu, A.-Y.; Morriss, S. C.; Mugume, Y.; Kazibwe, Z.; Ridout, V.; Luo, X.; MacIntosh, G. C.; Bassham, D. C.
10.1101/2021.07.28.454214 — plant biology — Posted on 2024-04-07
3693 Benchmark of cellular deconvolution methods using a multi-assay reference dataset from postmortem human prefrontal cortex
Huuki-Myers, L. A.; Montgomery, K. D.; Kwon, S. H.; Cinquemani, S.; Eagles, N. J.; Gonzalez-Padilla, D.; Maden, S. K.; Kleinman, J. E.; Hyde, T. M.; Hicks, S. C.; Maynard, K. R.; Collado-Torres, L.
10.1101/2024.02.09.579665 — neuroscience — Posted on 2024-04-07
3695 A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use
Weng, Y.; Kruschwitz, J.; Rueda-Delgado, L. M.; Ruddy, K. L.; Boyle, R.; Franzen, L.; Serin, E.; Nweze, T.; Hanson, J.; Smyth, A.; Farnan, T.; Banaschewski, T.; Bokde, A. L.; Desrivieres, S.; Flor, H.; Grigis, A.; Garavan, H.; Gowland, P. A.; Heinz, A.; Brühl, R.; Martinot, J.-L.; Martinot, M.-L. P.; Artiges, E.; McGrath, J.; Nees, F.; Papadopoulos Orfanos, D.; Paus, T.; Poustka, L.; Nathalie Holz, N.; Fröhner, J.; Smolka, M. N.; Vaidya, N.; Schumann, G.; Walter, H.; Whelan, R.
10.1101/2024.04.03.587900 — neuroscience — Posted on 2024-04-07
3696 Regulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15
Ebenwaldner, C.; Garcia Saura, A. G.; Ekstrom, S.; Bernfur, K.; Schuler, H.
10.1101/2024.04.04.588081 — biochemistry — Posted on 2024-04-07
3697 Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers
Boruah, N.; Hoyos, D.; Moses, R.; Hausler, R.; Desai, H.; Le, A. N.; Good, M.; Kelly, G.; Raghavakaimal, A.; Tayeb, M.; Narasimhamurthy, M.; Doucette, A.; Gabriel, P.; Feldman, M. J.; Park, J.; Lopez de Rodas Gregorio, M.; Schalper, K. A.; Goldfarb, S. B.; Nayak, A.; Levine, A. J.; Greenbaum, B. D.; Maxwell, K. N.
10.1101/2024.04.03.588009 — genetics — Posted on 2024-04-07
3700 EMERGENCE OF OXA-48-LIKE CARBAPENEMASES IN CLINICAL ENTEROBACTERALES FROM GUATEMALA
Mazariegos, C. J.; Quinto, A.; Herrera, A.; Barillas, S. E.; Valenzuela, L. R.; Ordonez, G.; Sierra, P.; Arevalo, C.; Seah, C.; Melano, R. G.
10.1101/2024.04.04.588149 — microbiology — Posted on 2024-04-07
3705 A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use
weng, y.; Kruschwitz, J.; Rueda-Delgado, L. M.; Ruddy, K. L.; Boyle, R.; Franzen, L.; Serin, E.; Nweze, T.; Hanson, J.; Smyth, A.; Farnan, T.; Banaschewski, T.; Bokde, A. L.; Desrivieres, S.; Flor, H.; Grigis, A.; Garavan, H.; Gowland, P. A.; Heinz, A.; Brühl, R.; Martinot, J.-L.; Martinot, M.-L. P.; Artiges, E.; McGrath, J.; Nees, F.; Papadopoulos Orfanos, D.; Paus, T.; Poustka, L.; Nathalie Holz, N.; Fröhner, J.; Smolka, M. N.; Vaidya, N.; Schumann, G.; Walter, H.; Whelan, R.
10.1101/2024.04.03.587900 — neuroscience — Posted on 2024-04-07
3714 Structural plasticity of 2A proteins in the Parechovirus family
Zhu, L.; Pichon, M.; Pietras, Z.; Wang, X.; Ren, J.; Fry, E. E.; Stuart, D. I.; Perrakis, A.; von Castelmur, E.
10.1101/2024.04.06.588386 — biochemistry — Posted on 2024-04-06
3715 Uncovering Protein Ensembles: Automated Multiconformer Model Building for X-ray Crystallography and Cryo-EM
Wankowicz, S. A.; Ravikumar, A.; Sharma, S.; Riley, B.; Raju, A.; Hogan, D. W.; Flowers, J.; van den Bedem, H.; Keedy, D. A.; Fraser, J. S.
10.1101/2023.06.28.546963 — biophysics — Posted on 2024-04-06
3716 lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
Maden, S. K.; Huuki-Myers, L. A.; Kwon, S. H.; Collado-Torres, L.; Maynard, K. R.; Hicks, S. C.
10.1101/2024.04.04.588105 — bioinformatics — Posted on 2024-04-06
3722 Cyr61 delivery promotes angiogenesis during bone fracture repair
Lang, A.; Eastburn, E. A.; Younesi, M.; Nijsure, M.; Siciliano, C.; Pranatharthi-Haran, A.; Panebianco, C.; Seidl, E.; Tang, R.; Alsberg, E.; Willett, N.; Gottardi, R.; Huh, D.; Boerckel, J. D.
10.1101/2024.04.05.588239 — bioengineering — Posted on 2024-04-06
3725 Determining the Youngs Modulus of the Bacterial Cell Envelope
Lee, J.; Jha, K.; Harper, C. E.; Zhang, W.; Ramsukh, M.; Bouklas, N.; Doerr, T.; Chen, P.; Hernandez, C. J.
10.1101/2024.04.04.588172 — bioengineering — Posted on 2024-04-06
3726 Structural basis for CCR6 modulation by allosteric antagonists
Wasilko, D. J.; Gerstenberger, B. S.; Farley, K. A.; Li, W.; Alley, J.; Schnute, M. E.; Unwalla, R. J.; Victorino, J.; Crouse, K. K.; Ding, R.; Sahasrabudhe, P. V.; Vincent, F.; Frisbie, R.; Dermenci, A.; Flick, A.; Choi, C.; Chinigo, G.; Mousseau, J.; Trujillo, J. I.; Nuhant, P.; Mondal, P.; Lombardo, V.; Lamb, D.; Segala, E.; Brown, P.; Oswald, C.; Windsor, I. W.; Han, S.; Rappas, M.; Cooke, R. M.; Calabrese, M. F.; Berstein, G.; Thorarensen, A.; Wu, H.
10.1101/2024.04.05.588354 — biochemistry — Posted on 2024-04-06
3728 Requirements for efficient endosomal escape by designed mini-proteins
Giudice, J.; Brauer, D. D.; Zoltek, M.; Vazquez, A.; Kelly, M. J. S.; Schepartz, A.
10.1101/2024.04.05.588336 — biochemistry — Posted on 2024-04-06
3729 NaV1.7 targeted fluorescence imaging agents for nerve identification during intraoperative procedures
Gonzales, J.; Adilbay, D.; de Souza Franca, P. D.; Artschwager, R.; Chow, C. Y.; Viray, T.; Johnson, D. S.; Jiang, Y.; G. Patel, S.; Ganly, I.; I. Schroeder, C.; S. Lewis, J.; F. King, G.; Reiner, T.; Pillarsetty, N.
10.1101/2024.04.06.588368 — biochemistry — Posted on 2024-04-06
3733 Interstitial pneumonia via the oropharyngeal route of infection with Encephalitozoon cuniculi
Santos, M. S.; da Silva, R. A.; de Souza, L. N.; Victorino, N. R.; Pereira, R. C. B.; Xavier, J. G.; da Silva, R. A.; Perez, E. C.; Alvares-Saraiva, A. M.; Lallo, M. A.
10.1101/2024.04.04.588046 — pathology — Posted on 2024-04-06
3734 Compromised actin dynamics underlie the orofacial cleft in Baraitser-Winter Cerebrofrontofacial Syndrome with a variant in ACTB
Tsujimoto, T.; Ou, Y.; Suzuki, M.; Murata, Y.; Inubushi, T.; Nagata, M.; Ishihara, Y.; Yonei, A.; Miyashita, Y.; Asano, Y.; Sakai, N.; Ogino, H.; Sakata, Y.; Yamashiro, T.; Kurosaka, H.
10.1101/2024.04.04.587685 — genetics — Posted on 2024-04-06
3735 Endo-reduplication in mouse liver after conditional mutation of ORC2 and combined mutation of ORC1 and ORC2
Przanowska, R. K.; Chen, Y.; Uchida, T. O.; Shibata, E.; Hao, X.; Rueda, I. S.; Jensen, K.; Przanowski, P.; Trimboli, A.; Shibata, Y.; Leone, G.; Dutta, A.
10.1101/2024.04.04.588006 — genetics — Posted on 2024-04-06
3740 Antigenic cartography using hamster sera identifies SARS-CoV-2 JN.1 evasion seen in human XBB.1.5 booster sera
WANG, W.; Bhushan, G. L.; Paz, S.; Stauft, C. B.; Selvaraj, P.; Goguet, E.; Bishop-Lilly, K. A.; Subramanian, R.; Vassell, R.; Lusvarghi, S.; Cong, Y.; Agan, B.; Richard, S. A.; Epsi, N.; Fries, A.; Fung, C. K.; Conte, M.; Holbrook, M.; Wang, T. T.; Burgess, T. H.; Mitre, E.; Pollett, S.; Katzelnick, L.; Weiss, C. D.
10.1101/2024.04.05.588359 — microbiology — Posted on 2024-04-06
3741 Mechanism of enterovirus VP0 maturation cleavage based on the structure of a stabilised assembly intermediate.
Kingston, N. J.; Snowden, J. S.; Grehan, K.; Hall, P. K.; Hietanen, E. V.; Passchier, T. C.; Polyak, S. J.; Filman, D. J.; Hogle, J. M.; Rowlands, D.; Stonehouse, N. J.
10.1101/2024.04.06.588229 — microbiology — Posted on 2024-04-06
3743 Elasmobranchs Exhibit Species-Specific Epidermal Microbiomes Guided by Denticle Topography
Goodman, A. Z.; Papudeshi, B.; Mora, M. F.; Kerr, E. N.; Torres, M.; Nero Moffatt, J.; Lima, L. F.; Niesman, I.; Moreno, I. Y.; Doane, M.; Dinsdale, E. A.
10.1101/2024.04.05.588334 — microbiology — Posted on 2024-04-06
3744 Sinorhizobium meliloti BR-bodies promote fitness during host colonization
Mallikaarachchi, K. S.; Huang, J. L.; Madras, S.; Cuellar, R. A.; Huang, Z.; Gega, A.; Rathnayaka-Mudiyanselage, I. W.; Al-Husini, N.; Saldana-Rivera, N.; Ma, L. H.; Ng, E.; Chen, J. C.; Schrader, J. M.
10.1101/2024.04.05.588320 — microbiology — Posted on 2024-04-06
3746 Epithelial Hexokinase 2 expression is a marker for intestinal inflammation
Weber-Stiehl, S.; Taubenheim, J.; Jaerke, L.; Roecken, C.; Schreiber, S.; Aden, K.; Kaleta, C.; Rosenstiel, P.; Sommer, F.
10.1101/2024.04.04.588060 — immunology — Posted on 2024-04-06
3748 RNA language models predict mutations that improve RNA function
Shulgina, Y.; Trinidad, M. I.; Langeberg, C. J.; Nisonoff, H.; Chithrananda, S.; Skopintsev, P.; Nissley, A. J.; Patel, J.; Boger, R. S.; Shi, H.; Yoon, P. H.; Doherty, E. E.; Pande, T.; Iyer, A. M.; Doudna, J. A.; Cate, J. H. D.
10.1101/2024.04.05.588317 — synthetic biology — Posted on 2024-04-06
3749 Structural insights into the human P2X1 receptor and ligand interactions
Bennetts, F.; Venugopal, H.; Glukhova, A.; Mobbs, J. I.; Ventura, S.; Thal, D. M.
10.1101/2024.04.04.588192 — pharmacology and toxicology — Posted on 2024-04-06
3750 Coordinated regulation by lncRNAs results in tight lncRNA-target couplings
Chiu, H.-S.; Somvanshi, S.; de Lavergne, E. d. B.; Wei, Z.; Trypsteen, W.; Scorsone, K. A.; Patel, E.; Tang, T. T.; Flint, D. B.; Najaf Panah, M. J.; Kim, H. R.; Rathi, P.; Lee, Y.-H. W.; Woodfield, S.; Vasudevan, S. A.; Heczey, A. A.; Chen, T.-W.; Gaber, M. W.; Sawakuchi, G. O.; Mestdagh, P.; Yang, X.; Sumazin, P.
10.1101/2024.04.05.588182 — bioinformatics — Posted on 2024-04-06
3751 Electromagnetic Modeling within a Microscopically Realistic Brain - Implications for Brain Stimulation
Qi, Z.; Noetscher, G. M.; Miles, A.; Weise, K.; Knosche, T.; Cadman, C. R.; Potashinsky, A. R.; Liu, K.; Wartman, W. A.; Nunez Ponasso, G. C.; Bikson, M.; Lu, H.; Deng, Z.-D.; Nummenmaa, A.; Makaroff, S. N.
10.1101/2024.04.04.588004 — neuroscience — Posted on 2024-04-06
3753 Genome-wide profiling of the hierarchical control of autophagy dynamics using deep learning
Chica, N.; Andersen, A. N.; Orellana-Munoz, S.; Garcia, I.; Nguea P, A.; Ayuda-Duran, P.; Hakensbakken, L.; Rodningen, E.; Putnam, C. D.; Zucknick, M.; Rusten, T. E.; Enserink, J. M.
10.1101/2024.04.06.588104 — systems biology — Posted on 2024-04-06
3756 A new high-quality genome assembly and annotation for the threatened Florida Scrub-Jay (Aphelocoma coerulescens)
Romero, F. G.; Beaudry, F. E. G.; Hovmand Warner, E.; Nguyen, T. N.; Fitzpatrick, J. W.; Chen, N.
10.1101/2024.04.05.588142 — genomics — Posted on 2024-04-06
3757 Transiently restricting individual amino acids protects D. melanogaster against multiple stressors
Fulton, T. L.; Johnstone, J. N.; Tan, J. J.; Balagopal, K.; Dedman, A.; Johnson, T. K.; Chan, A. Y.; Mirth, C. K.; Piper, M. D. W.
10.1101/2024.04.04.588160 — genetics — Posted on 2024-04-06
3760 Microgliosis driven by palmitate exposure alters energy metabolism and extracellular vesicles release that impact behavior and systemic metabolism
de Paula, G. C.; Aldana, B.; Battistella, R.; Fernandez Calle, R.; Bjure, A.; Lundgaard, I.; Deierborg, T.; Duarte, J. M. N.
10.1101/2024.04.04.587954 — neuroscience — Posted on 2024-04-06
3761 Interleukin-6 induces nascent protein synthesis in human DRG nociceptors via MNK-eIF4E signaling
Mitchell, M. E.; Torrijos, G.; Cook, L. F.; Mwirigi, J. M.; He, L.; Shiers, S.; Price, T. J.
10.1101/2024.04.04.588080 — neuroscience — Posted on 2024-04-06
3764 NovoLign: metaproteomics by sequence alignment
Kleikamp, H.; van der Zwaan, R.; van Valderen, R.; van Ede, J.; Pronk, M.; Schaasberg, P.; Allaart, M.; van Loosdrecht, M.; Pabst, M.
10.1101/2024.04.04.588008 — systems biology — Posted on 2024-04-06
3767 Comparative metagenomic profiling of seed-borne microbiomes in a landrace and a hybrid maize variety
Henaut-Jacobs, S.; Cyriaco, B. E. B.; Pedrosa-Silva, F.; Olivares, F. L.; Venancio, T. M.
10.1101/2024.04.04.588073 — plant biology — Posted on 2024-04-06
3768 Ovarian support cell in vitro maturation (OSC-IVM) results in healthy murine live births with no evidence of reprotoxicology in a multigenerational study
Marchante, M.; Barrachina, F.; Mestres, E.; Acacio, M.; Potts, K. S.; Piechota, S.; Paulsen, B.; Noblett, A. D.; Figueroa, A. B.; Costa-Borges, N.; Kramme, C. C.
10.1101/2024.04.04.588122 — pharmacology and toxicology — Posted on 2024-04-06
3770 SPARROW reveals cell states and functions influenced by microenvironment zones in complex tissues.
Zhao, P. A.; Li, X.-j.; Garber, J.; Savage, A. K.; Skene, P.; Kim, J.; Gustafson, C. E.
10.1101/2024.04.05.588159 — bioinformatics — Posted on 2024-04-06
3776 A blueprint for national assessments of the blue carbon capacity of kelp forests applied to Canadas coastline
McHenry, J.; Okamoto, D. K.; Filbee-Dexter, K.; Krumhansl, K.; MacGregor, K.; Hessing-Lewis, M.; Timmer, B.; Archambault, P.; Attridge, C.; Cottier, D.; Costa, M.; Csordas, M.; Johnson, L. E.; Lessard, J.; Mora-Soto, A.; Metaxas, A.; Neufeld, C.; Pontier, O.; Reshitnyk, L.; Starko, S.; Yakimishyn, J.; Baum, J. K.
10.1101/2024.04.05.586816 — ecology — Posted on 2024-04-06
3779 BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection
Rajan, A.; Gallego, P.; Dolan, B.; Patel, P.; Dwibedi, C.; Luis, A. S.; Trillo-Muyo, S.; Arike, L.; van der Post, S.; Simren, M.; Pelaseyed, T.
10.1101/2024.04.06.584567 — microbiology — Posted on 2024-04-06
3781 Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis
Ou, Z.; Li, L.; Ren, P.; Zhou, T.; He, F.; Chen, J.; Cai, H.; Han, X.; Wu, Y.; Li, J.; Li, X.; Tan, Q.; Li, W.; Chen, Q.; Zhang, N.; He, X.; Chen, W.; Zhao, Y.; Sun, J.; Zhang, Q.; Wu, Y.; Liang, Y.; You, J.; Hu, G.; Tian, X.; Liao, S.; Fu, B.; Chen, A.; Cai, X.; Yang, H.; Wang, J.; Jin, X.; Xu, X.; Jia, W.; Li, J.; Yan, H.
10.1101/2024.04.04.577902 — immunology — Posted on 2024-04-06
3782 The auditory midbrain mediates tactile vibration sensing
Huey, E. L.; Turecek, J.; Delisle, M. M.; Mazor, O.; Romero, G. E.; Dua, M.; Sarafis, Z. K.; Hobble, A.; Booth, K. T.; Goodrich, L. V.; Corey, D. P.; Ginty, D. D.
10.1101/2024.03.08.584077 — neuroscience — Posted on 2024-04-06
3784 SwinCell: a transformer-based framework for dense 3D cellular segmentation
Zhang, X.; Lin, Z.; Wang, L.; Chu, Y.; Yang, Y.; Xiao, X.; Lin, Y.; Liu, Q.
10.1101/2024.04.05.588365 — cell biology — Posted on 2024-04-06
3785 A Serum- and Feeder-Free System to Generate CD4 and Regulatory T Cells from Human iPSCs
Fong, H.; Mendel, M.; Jascur, J.; Najmi, L.; Kim, K.; Lew, G.; Garimalla, S.; Schock, S.; Hu, J.; Villegas, A.; Conway, A.; Fontenot, J. D.; Zompi, S.
10.1101/2023.07.01.547333 — cell biology — Posted on 2024-04-06
3789 The oocyte microenvironment is altered in adolescents compared to oocyte donors.
Gokyer, D.; Akinboro, S.; Zhou, L. T.; Kleinhans, A.; Laronda, M. M.; Duncan, F. E.; Riley, J. K.; Goldman, K. N.; Babayev, E.
10.1101/2024.04.04.588118 — developmental biology — Posted on 2024-04-06
3794 TOTEM: A web TOol for Tissue-EnrichMent analysis on gene lists
Coleto-Alcudia, V.; Lozano-Elena, F.; Vera, G.; Betegon-Putze, I.; Gupta, A.; Efroni, I.; Cano-Delgado, A. I.
10.1101/2024.04.04.588116 — plant biology — Posted on 2024-04-06
3798 Wax ester synthase overexpression affects stomatal development, water consumption and growth of poplars
Amirkhosravi, A.; Strijkstra, G.-J.; Keyl, A.; Haffner, F.; Lipka, U.; Herrfurth, C.; Feussner, I.; Polle, A.
10.1101/2024.04.06.588381 — plant biology — Posted on 2024-04-06
3801 ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity
Feng, W.; Ladewig, E.; Salsabeel, N.; Zhao, H.; Lee, Y. S.; Gopalan, A.; Lange, M.; Luo, H.; Kang, W.; Fan, N.; Rosiek, E.; De Stanchina, E.; Chen, Y.; Carver, B. S.; Leslie, C. S.; Sawyers, C.
10.1101/2023.05.15.540839 — cancer biology — Posted on 2024-04-06
3802 A Multiparametric Analysis Reveals Differential Behavior of Spheroid Cultures on Distinct Ultra-Low Attachment Plates Types
Vitacolonna, M.; Bruch, R.; Agaci, A.; Nuernberg, E.; Cesetti, T.; Keller, F.; Padovani, F.; Sauer, S.; Schmoller, K. M.; Reischl, M.; Hafner, M.; Rudolf, R.
10.1101/2024.03.26.586778 — cancer biology — Posted on 2024-04-06
3805 Dietary protein source strongly alters gut microbiota composition and function
Blakeley-Ruiz, J. A.; Bartlett, A.; McMillan, A. S.; Awan, A.; Vanhoy Walsh, M.; Meyerhoffer, A. K.; Vintila, S.; Maier, J.; Richie, T.; Theriot, C. M.; Kleiner, M.
10.1101/2024.04.04.588169 — microbiology — Posted on 2024-04-06
3809 Ligand requirements for immunoreceptor triggering
Barton, M. I.; Paterson, R. L.; Denham, E. M.; Goyette, J.; van der Merwe, P. A.
10.1101/2023.09.11.557203 — immunology — Posted on 2024-04-06
3811 Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.
Heij, L. R.; Hayat, S.; Reichel, K.; Maryam, S.; Rourke, C.; Tan, X.; van den Braber, M.; Verhoeff, J.; Halder, M.; Peisker, F.; Wiltberger, G.; Bednarsch, J.; Heise, D.; Campello Deierl, J.; Lang, S.; Ulmer, F.; Luedde, T.; Dahl, E.; Jonigk, D.; Nolting, J.; Sivakumar, S.; Siveke, J.; Rocha, F.; Baba, H.; Andersen, J.; Garcia Vallejo, J.; Kramann, R.; Neumann, U.
10.1101/2024.02.03.578669 — cancer biology — Posted on 2024-04-06
3817 A newly-identified IncY plasmid from multi-drug resistant Escherichia coli isolated from dairy cattle feces in Poland
Zalewska, M.; Blazejewska, A.; Gawor, J.; Adamska, D.; Goryca, K.; Szelag, M.; Kalinowski, P.; Popowska, M.
10.1101/2024.04.05.588223 — microbiology — Posted on 2024-04-06
3818 WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation
Ge, Y.; Chen, R.; Ling, T.; Liu, B.; Huang, J.; Cheng, Y.; Lin, Y.; Chen, H.; Xie, X.; Xia, G.; Luo, G.; Yuan, S.; Xu, A.
10.1101/2023.10.30.564747 — immunology — Posted on 2024-04-06
3819 A tunable and versatile chemogenetic near infrared fluorescent reporter
El Hajji, L.; Bunel, B.; Joliot, O.; Li, C.; Tebo, A. G.; Rampon, C.; Volovitch, M.; Fischer, E.; Pietrancosta, N.; Perez, F.; Morin, X.; VRIZ, S.; Gautier, A.
10.1101/2024.04.05.588310 — cell biology — Posted on 2024-04-06
3821 Adolescent Seizure Impacts Oligodendrocyte Development, Neuronal-Glial Circuit Formation, and Myelination
Foutch, K.; Tilton, I.; Cooney, A.; Brock, R.; Gupta, R.; Bender, C.; Franzia, C.; Garcia, M. F.; Baldemor, M.; Deneen, J.; Arellano-Reyes, C.; Moura, D.; Noguchi, H.; Cocas, L.
10.1101/2024.04.05.588329 — neuroscience — Posted on 2024-04-05
3823 Missense mutation in the activation segment of the kinase CK2 models Okur Chung neurodevelopmental disorder and alters the hippocampal glutamatergic synapse
Cruz-Gamero, J. M.; Ballardin, D.; Barbara, L.; Zhang, C.-L.; Cobret, L.; Gast, A.; Morisset-Lopez, S.; Piskorowski, R.; Langui, D.; Jose, J.; Chevreux, G.; Rebholz, H.
10.1101/2024.04.04.588084 — neuroscience — Posted on 2024-04-05
3826 Temporal Dynamics of Neocortical Development in Organotypic Mouse Cultures: A Comprehensive Analysis
Bak, A. V.; Schmied, K.; Jakob, M.; Bedogni, F.; Squire, O.; Gittel, B.; Jesinghausen, M.; Schuenemann, K.; Weber, Y.; Kampa, B.; van Loo, K. M. J.; Koch, H.
10.1101/2024.04.05.588217 — neuroscience — Posted on 2024-04-05
3829 A new cellular platform for studying autophagy
Goldin-Azulay, K.; Fraiberg, M.; Trofimyuk, O.; Reuven, N.; Levin, Y.; Kopitman, E.; Elazar, Z.
10.1101/2024.03.28.587157 — cell biology — Posted on 2024-04-05
3831 Circulating, cell-free methylated DNA indicates cellular sources of allograft injury after liver transplant
McNamara, M. E.; Jain, S. S.; Oza, K.; Muralidaran, V.; Kiliti, A. J.; McDeed, A. P.; Patil, D.; Cui, Y.; Schmidt, M. O.; Riegel, A. T.; Kroemer, A. H. K.; Wellstein, A.
10.1101/2024.04.04.588176 — molecular biology — Posted on 2024-04-05
3834 behaviorMate: An Intranet of Things Approach for Adaptable Control of Behavioral and Navigation-Based Experiments
Bowler, J. C.; Zakka, G.; Yong, H. C.; Li, W.; Rao, B.; Liao, Z.; Priestley, J. B.; Losonczy, A.
10.1101/2023.12.04.569989 — neuroscience — Posted on 2024-04-05
3835 Chloroplast Methyltransferase Homolog RMT2 is Involved in Photosystem I Biogenesis
Kim, R. G.; Huang, W.; Findinier, J.; Bunbury, F.; Redekop, P.; Shrestha, R.; Grismer, T.; Vilarrasa-Blasi, J.; Jinkerson, R. E.; Fakhimi, N.; Fauser, F.; Jonikas, M. C.; Onishi, M.; Xu, S.-L.; Grossman, A. R.
10.1101/2023.12.21.572672 — plant biology — Posted on 2024-04-05
3837 Flow zoometry of Drosophila
Peterson, W.; Arenson, J.; Hata, S.; Kacenauskaite, L.; Kobayashi, T.; Otsuka, T.; Wang, H.; Wada, Y.; Hiramatsu, K.; He, Z.; Clement, J.-E.; Zhang, C.; Hu, C.; McCann, P.; Kanazawa, H.; Nagasaka, Y.; Uechi, H.; Watanabe, Y.; Yamamura, R.; Hayashi, M.; Nakagawa, Y.; Huang, K.; Kanno, H.; Zhou, Y.; Ding, T.; Herbig, M.; Makino, S.; Nonaga, S.; Takami, R.; Kanca, O.; Tabata, K.; Amaya, S.; Furusawa, K.; Ishii, K.; Emoto, K.; Arai, F.; Cagan, R.; Di Carlo, D.; Igaki, T.; Kuranaga, E.; Yamamoto, S.; Bellen, H. J.; Komatsuzaki, T.; Sonoshita, M.; Goda, K.
10.1101/2024.04.04.588032 — bioengineering — Posted on 2024-04-05
3838 Fragility of ER homeostatic regulation underlies haploid instability in human somatic cells
Ishida-Ishihara, S.; Yaguchi, K.; Sato, K.; Yoshizawa, K.; Miura, S.; Yang, G.; Veszelyi, K.; Banhegyi, G.; Margittai, E.; Uehara, R.
10.1101/2024.04.05.588249 — biochemistry — Posted on 2024-04-05
3842 The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis
Kretov, D.; Folkes, L.; Mora-Martin, A.; Syedah, N.; Walawalkar, I. A.; Vanuytsel, K.; Murphy, G. J.; Moxon, S.; Cifuentes, D.
10.1101/2023.07.18.549576 — developmental biology — Posted on 2024-04-05
3848 AlbuMAX supplemented media induces the formation of transmission-competent P. falciparum gametocytes
Graumans, W.; Starre, A. v. d.; Stoter, R.; Gemert, G.-J. v.; Andolina, C.; Ramjith, J.; Kooij, T. W. A.; Bousema, T.; Proellochs, N.
10.1101/2024.04.05.588064 — microbiology — Posted on 2024-04-05
3849 The RNA landscape of the human commensal Segatella copri reveals a small RNA essential for gut colonization
El Mouali, Y.; Tawk, C.; Huang, K. D.; Amend, L.; Lesker, T. R.; Ponath, F.; Vogel, J.; Strowig, T.
10.1101/2024.04.05.588293 — microbiology — Posted on 2024-04-05
3851 Super-resolution going viral: T4 virus particles as perfect nature-designed 3D-Bio-NanoRulers
Gallea, J. I.; Nevskyi, O.; Kazmierczak, Z.; Chen, T.; Miernikiewicz, P.; Chizhik, A.; Dabrowska, K.; Bates, M.; Enderlein, J.
10.1101/2024.04.04.588072 — biophysics — Posted on 2024-04-05
3854 Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae
Tsang, K. K.; Lam, M. M. C.; Wick, R. R.; Wyres, K. L.; Bachman, M. A.; Baker, S.; Barry, K.; Brisse, S.; Campino, S.; Chiaverini, A.; Cirillo, D. M.; Clark, T. G.; Corander, J.; Corbella, M.; Cornacchia, A.; Cuenod, A.; D'Alterio, N.; Di Marco, F.; Donado-Godoy, P.; Egli, A.; Farzana, R.; Feil, E. J.; Fostervold, A.; Gorrie, C. L.; Gütlin, Y.; Hassan, B.; Hetland, M. A. K.; Hoa, L. N. M.; Hoi, L. T.; Howden, B.; Ikhimiukor, O. O.; Jenney, A. W.; Kaspersen, H.; Khokhar, F.; Leangapichart, T.; Ligowska-Marzeta, M.; Löhr, I. H.; Long, S. W.; Mathers, A. J.; McArthur, A. G.; Nagaraj, G.; Oaikhe
10.1101/2024.04.05.587953 — genomics — Posted on 2024-04-05
3855 In vitro host transcriptomics during Cryptococcus neoformans, Cryptococcus gattii, and Candida albicans infection of South African volunteers
Doyle, R. M.; Kannambath, S.; Pittman, A.; Goliath, R.; Kumar, V.; Meintjes, G.; Milburn, J.; Netea, M. G.; Harrison, T. S.; Jarvis, J. N.; Bicanic, T.
10.1101/2024.04.05.588257 — genomics — Posted on 2024-04-05
3856 MtrAB two-component system is crucial for the intrinsic resistance and virulence of Mycobacterium abscessus
Zhang, J.; Ju, Y.; Li, L.; Adnan, H. M.; Yusuf, B.; Gao, Y.; Fang, C.; Tian, X.; Ding, J.; Ma, W.; Chen, X.; Wang, S.; Zhang, T.
10.1101/2024.04.05.588258 — microbiology — Posted on 2024-04-05
3859 A newly-identified IncY plasmid from multi-drug resistant Escherichia coli isolated from dairy cattle feces in Poland
Zalewska, M.; Blazejewska, A.; Gawor, J.; Adamska, D.; Goryca, K.; Szelag, M.; Kalinowski, P.; Popowska, M.
10.1101/2024.04.05.588223 — microbiology — Posted on 2024-04-05
3860 Microbial two front attack: elaborate root infections by Colletotrichum graminicola oval conidia during maize anthracnose
Rudolph, A. Y.; Schunke, C.; Sasse, C.; Antelo, L.; Gerke, J.; Braus, G.; Poeggeler, S.; Nordzieke, D. E.
10.1101/2024.04.05.588234 — microbiology — Posted on 2024-04-05
3861 Cameroonian blackflies (Diptera: Simuliidae) harbour a plethora of (RNA) viruses
De Coninck, L.; Hadermann, A.; Ingletto, L.; Colebunders, R.; Njamnshi, K. G.; Njamnshi, A. K.; Mokili, J.; Siewe Fodjo, J. N.; Matthijnssens, J.
10.1101/2024.04.05.588247 — microbiology — Posted on 2024-04-05
3862 A mechanistic step in the genesis of secondary chromosomes from plasmids
Fournes, F.; Campos, M.; Cury, J.; Schiavon, C.; Pages, C.; Touchon, M.; Rocha, E. P. C.; Rousseau, P.; Cornet, F.
10.1101/2024.04.05.588136 — microbiology — Posted on 2024-04-05
3863 Dietary protein source strongly alters gut microbiota composition and function
Blakeley-Ruiz, J. A.; Bartlett, A.; McMillan, A. S.; Awan, A.; Vanhoy Walsh, M.; Meyerhoffer, A. K.; Vintila, S.; Maier, J.; Richie, T.; Theriot, C. M.; Kleiner, M.
10.1101/2024.04.04.588169 — microbiology — Posted on 2024-04-05
3864 Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection
Wang, R.; Senay, T. E.; Luo, T. T.; Regan, J. M.; Salisbury, N.; Galloway, D.; You, J.
10.1101/2024.04.05.588227 — microbiology — Posted on 2024-04-05
3866 Human iPSC-derived cell grafts promote functional recovery by molecular interaction with stroke-injured brain
Weber, R. Z.; Achon Buil, B.; Rentsch, N. H.; Perron, P.; Bosworth, A.; Zhang, M.; Kisler, K.; Bodenmann, C.; Zurcher, K. J.; Uhr, D.; Meier, D.; Peter, S. L.; Generali, M.; Nitsch, R. M.; Zlokovic, B. V.; Tackenberg, C.; Rust, R.
10.1101/2024.04.03.588020 — neuroscience — Posted on 2024-04-05
3869 Effects of Exercise Frequency on Aortic Calcification in Hyperlipidemic Mice
Safvati, N.; Kalanski, S.; Hon, A.; Pradhan, S.; Lu, O.; Demer, L. L.; Tintut, Y.
10.1101/2024.04.03.588017 — physiology — Posted on 2024-04-05
3871 Perceived biodiversity: is what we measure also what we see and hear?
Rozario, K.; Shaw, T.; Marselle, M.; Oh, R. R.-Y.; Schroeger, E.; Giraldo Botero, M.; Frey, J.; Stefan, V.; Mueller, S.; Scherer-Lorenzen, M.; Jaroszewicz, B.; Verheyen, K.; Bonn, A.
10.1101/2024.04.03.587905 — ecology — Posted on 2024-04-05
3872 Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.
Nguyen, T. M. L.; Guilloux, J.-P.; Defaix, C.; Mendez-David, I.; Etting, I.; Alvarez, J.-C.; McGowan, J. C.; Highland, J. N.; Zanos, P.; Lovett, J.; Moaddel, R.; Corruble, E.; David, D. J.; Gould, T. D.; Denny, C. A.; Gardier, A.
10.1101/2024.04.03.587904 — neuroscience — Posted on 2024-04-05
3875 Gαolf Regulates Biochemical Signaling in Neurons Associated with Movement Control and Initiation
Millett, M.; Heuberger, A.; Martin Castosa, E.; Comite, A.; Wagner, P.; Hall, D.; Gallardo, I.; Chambers, N. E.; Wagner, L.; Moehle, M. S.
10.1101/2024.04.03.587766 — neuroscience — Posted on 2024-04-05
3876 Conservation of cortical crowding distance across individuals in human V4
Kurzawski, J. W.; Qiu, B. S.; Majaj, N. J.; Benson, N. C.; Pelli, D.; Winawer, J.
10.1101/2024.04.03.587977 — neuroscience — Posted on 2024-04-05
3877 MODERATE ALCOHOL CONSUMPTION INDUCES LASTING IMPACTS ON PREFRONTAL CORTICAL SIGNALING IN MICE
Smith, G. C.; Griffith, K. R.; Sicher, A. R.; Brockway, D. F.; Proctor, E. A.; Crowley, N. A.
10.1101/2024.04.03.587955 — neuroscience — Posted on 2024-04-05
3880 Functional Bias of Contractile Control in Mouse Resistance Arteries
Haghbin, N.; Richter, D. M.; Kharche, S.; Kim, M. S. M.; Welsh, D. G.
10.1101/2024.04.03.588016 — physiology — Posted on 2024-04-05
3881 Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression
Yue, S. S.; Tong, Y.; Siu, H. C.; Ho, S. L.; Law, S. Y.; Tsui, W. Y.; Chan, D.; Huang, Y.; Chan, A. S.; Yun, S. W.; Hui, H. S.; Chan, A. S.; Yuen, S. T.; Clevers, H.; Leung, S. Y.; Yan, H. H.
10.1101/2024.04.03.588024 — cancer biology — Posted on 2024-04-05
3885 The genome sequence of the Violet Carpenter Bee, Xylocopa violacea (Linnaeus, 1785): a hymenopteran species undergoing range expansion.
Nash, W.; Man, A.; McTaggart, S.; Baker, K.; Barker, T.; Catchpole, L.; Durrant, A.; Gharbi, K.; Irish, N.; Kaithakottil, G.; Ku, D.; Providence, A.; Shaw, F.; Swarbreck, D.; Watkins, C.; Mc Cartney, A.; Formenti, G.; Mouton, A.; Vella, N.; von Reumont, B. M.; Vella, A.; Haerty, W.
10.1101/2024.04.03.587942 — genomics — Posted on 2024-04-05
3887 RUNX1 is Expressed in a Subpopulation of Dermal Fibroblasts and Higher RUNX1 Levels are Associated with the Severity of Systemic Sclerosis
Parvizi, R.; Gong, Z.; Jarnagin, H. C.; Toledo, D. M.; Abel, T. R.; Popovich, D.; Morrisson, M. J.; Shenk, S.; Hinchcliff, M. E.; Garlick, J. A.; Pioli, P. A.; Whitfield, M. L.
10.1101/2024.04.03.587966 — genomics — Posted on 2024-04-05
3888 Comparison of spatial transcriptomics technologies used for tumor cryosections
Rademacher, A.; Huseynov, A.; Bortolomeazzi, M.; Wille, S. J.; Schumacher, S.; Sant, P.; Keitel, D.; Okonechnikov, K.; Ghasemi, D.; Pajtler, K.; Mallm, J.-P.; Rippe, K.
10.1101/2024.04.03.586404 — genomics — Posted on 2024-04-05
3891 Sensory weighting reflects changing patterns of visual investment during ecological divergence in Heliconius butterflies.
Borrero, J.; Mogollon Perez, E. A.; Wright, D. S.; Lozano, D.; Rueda-Munoz, G.; Pardo-Diaz, C.; Salazar, C.; Montgomery, S. H.; Merrill, R. M.
10.1101/2024.04.03.587949 — evolutionary biology — Posted on 2024-04-05
3894 Macro-environment strongly interacts with warming in a global analysis of decomposition
Schwieger, S.; Dorrepaal, E.; Petit Bon, M.; Vandvik, V.; le Roux, E.; Strack, M.; Yang, Y.; Venn, S.; van den Hoogen, J.; Valino, F.; Thomas, H. J. D.; te Beest, M.; Suzuki, S.; Petraglia, A.; Myers-Smith, I. H.; Munir, T. M.; Michelsen, A.; Lokken, J. O.; Li, Q.; Koike, T.; Klanderud, K.; Karr, E. H.; Jonsdottir, I. S.; Hollister, R. D.; Hofgaard, A.; Hassan, I. A.; Genxu, W.; Filippova, N.; Crowther, T. W.; Clark, K.; Christiansen, C. T.; Casanova-Katny, A.; Carbognani, M.; Bokhorst, S.; Bjornsdottir, K.; Asplund, J.; Althuizen, I.; Alonso, R.; Alatalo, J.; Agathokleous, E.; Aerts, R.; Sarn
10.1101/2024.04.03.587921 — ecology — Posted on 2024-04-05
3895 B cell αv integrin regulates germinal center derived lung-resident IgA B cell responses following influenza virus infection
Montiel-Armendariz, A.; Roe, K.; Lagos-Orellana, J.; Martinez-Castro, L. V.; Lacy-Hulbert, A.; Acharya, M.
10.1101/2024.04.03.587969 — immunology — Posted on 2024-04-05
3896 Prominent involvement of acetylcholine in shaping stable olfactory representation across the Drosophila brain
Fan, J.; Wang, Y.; Li, L.; He, J.; Zhao, Z.; Deng, F.; Li, G.; Li, X.; Zhou, Y.; Zhao, J.; Li, Y.; Wu, J.; Fang, L.; Dai, Q.
10.1101/2024.04.03.587915 — neuroscience — Posted on 2024-04-05
3899 Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors
Adam, E.; Kowalski, M.; Akeju, O.; Miller, E. K.; Brown, E. N.; McCarthy, M. M.; Kopell, N.
10.1101/2024.04.03.587998 — neuroscience — Posted on 2024-04-05
3903 Rating Pome Fruit Quality Traits Using Deep Learning and Image Processing
Nguyen, N. H.; Michaud, J.; Mogollon, R.; Zhang, H.; Hargarten, H.; Leisso, R.; Torres, C.; Honaas, L.; Ficklin, S.
10.1101/2024.04.03.588000 — plant biology — Posted on 2024-04-05
3904 Atypical epigenetic and small RNA control of transposons in clonally reproducing Spirodela polyrhiza.
Dombey, R.; Barragan-Borrero, V.; Buendia-Avila, D.; Ponce-Mane, A.; Vargas-Guerrero, J. M.; Elias, R.; Mari-Ordonez, A.
10.1101/2024.04.03.587901 — plant biology — Posted on 2024-04-05
3906 Osmosensing in trabecular meshwork cells
Baumann, J. M.; Yarishkin, O.; Lakk, M.; Rudzitis, C. N.; Tseng, Y.-T.; Krizaj, D.
10.1101/2024.04.03.587990 — physiology — Posted on 2024-04-05
3908 The microanatomy of human skin in aging
Han, K. S.; Sander, I. B.; Kumer, J.; Resnick, E. P.; Booth, C.; Starich, B.; Walston, J.; Kiemen, A. L.; Reddy, S.; Joshu, C.; Sunshine, J.; Wirtz, D.; Wu, P.-H.
10.1101/2024.04.03.588011 — pathology — Posted on 2024-04-05
3909 Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy
Pandya, P.; Vendetti, F. P.; El-Ghoubaira, J. A.; Pathak, S.; Deppas, J. J.; Jones, R. E.; Columbus, A. V.; Zhang, Y.; Ivanov, D.; Huang, Z.; MacDonald, K. M.; Harding, S. M.; Buj, R.; Aird, K. M.; Beumer, J. H.; Sobol, R. W.; Bakkenist, C. J.
10.1101/2024.04.04.588079 — cancer biology — Posted on 2024-04-05
3910 Predicting drug combination response surfaces
Huusari, R.; Wang, T.; Szedmak, S.; Aittokallio, T.; Rousu, J.
10.1101/2024.04.03.586729 — bioinformatics — Posted on 2024-04-05
3911 Learning Gaussian Graphical Models from Correlated Data
Song, Z.; Gunn, S.; Monti, S.; peloso, G.; Liu, C.-T.; Lunetta, K. L.; Sebastiani, P.
10.1101/2024.04.03.587948 — bioinformatics — Posted on 2024-04-05
3917 Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses
Matsui, A.; Spangler, C.; Elferich, J.; Shiozaki, M.; Jean, N.; Zhao, X.; Qin, M.; Zhong, H.; Yu, Z.; Gouaux, E.
10.1101/2024.04.01.587595 — biochemistry — Posted on 2024-04-05
3919 Mapping the dynamics of epigenetic adaptation during heterochromatin misregulation
Larkin, A.; Kunze, C.; Seman, M.; Levashkevich, A.; Curran, J.; Morris-Evans, D.; Lemieux, S.; Khalil, A. S.; Ragunathan, K.
10.1101/2023.07.10.548368 — genetics — Posted on 2024-04-05
3923 Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma
Tumuluru, S.; Godfrey, J. K.; Cooper, A.; Yu, J.; Chen, X.; MacNabb, B. W.; Venkataraman, G.; Zha, Y.; Pelzer, B.; Song, J.; Duns, G.; Sworder, B. J.; Bolen, C.; Penuel, E.; Postovalova, E.; Kotlov, N.; Bagaev, A.; Fowler, N.; Smith, S. M.; Alizadeh, A. A.; Steidl, C.; Kline, J.
10.1101/2024.01.17.576100 — cancer biology — Posted on 2024-04-05
3924 Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis
Ackermann, T.; Shokry, E.; Deshmukh, R.; Anand, J.; Galbraith, L. C. A.; Mitchell, L.; Rodriguez-Blanco, G.; Villar, V. H.; Sterken, B. A.; Nixon, C.; Zanivan, S.; Blyth, K.; Sumpton, D.; Tardito, S.
10.1101/2023.06.13.544588 — cancer biology — Posted on 2024-04-05
3927 ComPRePS: An Automated Cloud-based Image Analysis tool to democratize AI in Digital Pathology
Mimar, S.; Paul, A. S.; Lucarelli, N.; Boarder, S.; Santo, B. A.; Naglah, A.; Barisoni, L.; Hodgin, J.; Rosenberg, A.; Clapp, W.; Sarder, P.; for the Kidney Precision Medicine Project,
10.1101/2024.03.21.586102 — pathology — Posted on 2024-04-05
3928 Machine learning predictions improve identification of real-world cancer driver mutations
Tran, T. N.; Fong, C.; Pichotta, K.; Luthra, A.; Shen, R.; Chen, Y.; Waters, M.; Kim, S.; Berger, M. F.; Riely, G.; Ladanyi, M.; Chakravarty, D.; Schultz, N.; Jee, J.
10.1101/2024.03.31.587410 — genomics — Posted on 2024-04-05
3931 Reactivation strength during cued recall is modulated by graph distance within cognitive maps
Kern, S.; Nagel, J.; Gerchen, M. F.; Gürsoy, C.; Meyer-Lindenberg, A.; Kirsch, P.; Dolan, R. J.; Gais, S.; Feld, G. B.
10.1101/2023.07.31.551234 — neuroscience — Posted on 2024-04-05
3932 Interrogating basal ganglia circuit function in Parkinson's disease and dystonia
Sumarac, S.; Spencer, K. A.; Steiner, L. A.; Fearon, C.; Haniff, E.; Kuhn, A. A.; Hodaie, M.; Kalia, S. K.; Lozano, A. M.; Fasano, A.; Hutchison, W. D.; Milosevic, L.
10.1101/2023.08.26.554666 — neuroscience — Posted on 2024-04-05
3938 How motility drives the glassy dynamics in confluent epithelial monolayers?
Sadhukhan, S.; Nandi, M. K.; Pandey, S.; Paoluzzi, M.; Dasgupta, C.; Gov, N.; Nandi, S. K.
10.1101/2024.03.14.584932 — biophysics — Posted on 2024-04-05
3939 An Lgr5-independent developmental lineage is involved in mouse intestinal regeneration
Marefati, M.; Fernandez-Vallone, V.; Leprovots, M.; Vasile, G.; Libert, F.; Lefort, A.; Dinsart, G.; Weber, A.; Jetzer, J.; Garcia, M.-I.; Vassart, G.
10.1101/2024.03.11.584399 — developmental biology — Posted on 2024-04-05
3940 The Effects of Acute Coordinative vs. Acute Endurance Exercise on the Cortisol Concentration
Budde, H.; Wegner, M.; Ahrens, C.; Velasques, B.; Ribeiro, P.; Machado, S.; Gronwald, T.; Amatriain Fernandez, S.; Schaffarczyk, M.; Mueller-Alcazar, A.
10.1101/2024.03.25.586687 — physiology — Posted on 2024-04-05
3941 Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons
Lowry, E. R.; Patel, T.; Costa, J. A.; Chang, E.; Tariq, S.; Melikyan, H.; Davis, I. M.; Aziz, S.; Dermentzaki, G.; Lotti, F.; Wichterle, H.
10.1101/2024.04.03.587963 — neuroscience — Posted on 2024-04-05
3943 Brain-wide monosynaptic connectivity mapping with ROInet-seq
Lin, Z.; Ophir, O.; Trimbuch, T.; Brokowski, B.; Tibi, M.; Pavletsov, P.; Schmidt, H.; Rosenmund, C.; Hochgerner, H.; Zeisel, A.
10.1101/2024.04.04.588058 — neuroscience — Posted on 2024-04-05
3944 Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis
Schleifer, C. H.; Chang, S. E.; Amir, C. M.; O'Hora, K. P.; Fung, H.; Kang, J. W. D.; Kushan-Wells, L.; Daly, E.; Di Fabio, F.; Frascarelli, M.; Gudbrandsen, M.; Kates, W. R.; Murphy, D.; Addington, J.; Anticevic, A.; Cadenhead, K. S.; Cannon, T. D.; Cornblatt, B. A.; Keshavan, M.; Mathalon, D. H.; Perkins, D. O.; Stone, W.; Walker, E.; Woods, S. W.; Uddin, L. Q.; Kumar, K.; Hoftman, G. D.; Bearden, C. E.
10.1101/2024.04.03.587988 — neuroscience — Posted on 2024-04-05
3945 Multi-scale phenotyping of senescence-related changes in roots of rapeseed in response to nitrogen deficiency
James, M.; Masclaux-Daubresse, C.; Balliau, T.; Marmagne, A.; Chardon, F.; Trouverie, J.; Etienne, P.
10.1101/2024.04.03.587968 — plant biology — Posted on 2024-04-05
3947 The impact of package selection and versioning on single-cell RNA-seq analysis
Rich, J. M.; Moses, L.; Einarsson, P. H.; Jackson, K.; Luebbert, L.; Booeshaghi, A. S.; Antonsson, S.; Sullivan, D. K.; Bray, N.; Melsted, P.; Pachter, L.
10.1101/2024.04.04.588111 — bioinformatics — Posted on 2024-04-05
3948 Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone allosterically mediates substrate binding to the active site
Bimai, O.; Banerjee, I.; Grinberg, I. R.; Huang, P.; Hultgren, L.; Ekström, S.; Lundin, D.; Sjöberg, B.-M.; Logan, D. T.
10.1101/2023.06.20.545753 — biochemistry — Posted on 2024-04-05
3950 Phago-mixotrophy of small eukaryotic phytoplankton might alleviate iron limitation in HNLC Southern Ocean
Ong, D. R. Y.; Gutierrez-Rodriguez, A.; Safi, K. A.; Marie, D.; Selph, K. E.; Stukel, M. R.; Decima, M.; Lopes dos Santos, A.
10.1101/2024.01.08.574519 — microbiology — Posted on 2024-04-05
3951 Motor execution, but not learning, improves upon increased layer 5 specific Martinotti cell excitation
Velica, A.; Malfatti, T.; Winne, J.; Ciralli, B.; Henriksson, K.; Nogueira, I.; Asimakidou, E.; Nascimento, G.; Leao, R.; Kullander, K.
10.1101/2024.03.10.584276 — neuroscience — Posted on 2024-04-05
3952 Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome.
Lopes, F. M.; Grenier, C.; Jarvis, B. W.; Al Mahdy, S.; Lene-Mckay, A.; Gurney, A. M.; Newman, W. G.; Waddington, S. N.; Woolf, A. S.; Roberts, N. A.
10.1101/2023.07.03.547034 — neuroscience — Posted on 2024-04-05
3954 R6G narrows BmrA conformational spectrum for a more efficient use of ATP
Gobet, A.; Moissonnier, L.; Zarkadas, E.; Magnard, S.; Bettler, E.; Martin, J.; Terreux, R.; Schoehn, G.; Orelle, C.; Jault, J.-M.; Falson, P.; Chaptal, v.
10.1101/2024.03.15.585201 — biochemistry — Posted on 2024-04-05
3959 Synaptic proteome diversity is primarily driven by gene regulation of glutamate receptors and their regulatory proteins
Bayes, A.; Reig-Viader, R.; del Castillo-Berges, D.; Burgas-Pau, A.; Arco-Alonso, D.; Ramos-Vicente, D.; Sindreu, C.
10.1101/2024.04.04.588090 — neuroscience — Posted on 2024-04-04
3962 SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment
Pereyra, G.; Mateo, M. I.; Martin-Bermejo, M. J.; Miaja, P.; Klaassen, R.; Gruart, A.; Rueda-Carrasco, J.; Fernandez-Rodrigo, A.; Lopez-Merino, E.; Esteve, P.; Esteban, J. A.; Smit, A. B.; Delgado-Garcia, J. M.; Bovolenta, P.
10.1101/2024.04.04.588100 — neuroscience — Posted on 2024-04-04
3964 Distinct genetic pathways to music enjoyment
Bignardi, G.; Wesseldijk, L. W.; Mas-Herrero, E.; Zatorre, R. J.; Ullen, F.; Fisher, S. E.; Mosing, M. A.
10.1101/2024.04.04.588094 — genetics — Posted on 2024-04-04
3968 Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)
Kim, H. Y.; Kang, Y. J.; Kim, D. H.; Jang, J.; Lee, S. J.; Kim, G.; Koh, H. B.; Ko, Y. E.; Shin, H. M.; Lee, H.; Yoo, T.-H.; Lee, W.-W.
10.1101/2022.08.08.503143 — immunology — Posted on 2024-04-04
3969 Massively parallel identification of single-cell immunophenotypes
Cienciala, M.; Alvarez, L.; Berne, L.; Chena, D.; Fikar, P.; Holubova, M.; Kasl, H.; Lysak, D.; Luo, M.; Novackova, Z.; Ordonez, S.; Sramkova, Z.; Vlas, T.; Georgiev, D.
10.1101/2024.04.04.587924 — synthetic biology — Posted on 2024-04-04
3971 Rejuvenation of Senescent Cells by Low Frequency Ultrasound without Senolysis
Kureel, S. K.; Maroto, R.; Powell, S.; Margadant, F.; Blair, B.; Maisha, A.; Rasmussen, B.; Sheetz, M.
10.1101/2022.12.08.519320 — physiology — Posted on 2024-04-04
3973 New gamma interferon (IFN- g) algorithm for tuberculosis diagnosis in cynomolgus macaques
warit, s.; Meesawat, S.; Cheawchanlertfa, P.; Makhoa, N.; Srilohasin, P.; Kaewparuehaschai, M.; Noradechanon, K.; Pomcoke, A.; Kemthong, T.; Prammananan, T.; Kanitpun, R.; Palaga, T.; Malaivijitnond, S.; Chaiprasert, A.
10.1101/2024.04.04.588038 — microbiology — Posted on 2024-04-04
3974 T4 phage RNA is NAD-capped and alters the NAD-capepitranscriptome of Escherichia coli during infection through a phage-encoded decapping enzyme
Wolfram-Schauerte, M.; Moskalchuk, A.; Pozhydaieva, N.; Rojas, A. A. R.; Schindler, D.; Kaiser, S.; Paczia, N.; Höfer, K.
10.1101/2024.04.04.588121 — microbiology — Posted on 2024-04-04
3977 Lupus IgA1 autoantibodies synergize with IgG to enhance plasmacytoid dendritic cell responses to RNA-containing immune complexes
Waterman, H. R.; Dufort, M. J.; Posso, S. E.; Ni, M.; Li, L. Z.; Zhu, C.; Raj, P.; Smith, K. D.; Buckner, J. H.; Hamerman, J. A.
10.1101/2023.09.07.556743 — immunology — Posted on 2024-04-04
3982 Molecular basis of human nuclear and mitochondrial tRNA 3'-processing
Bhatta, A.; Kuhle, B.; Yu, R. D.; Spanaus, L.; Ditter, K.; Bohnsack, K. E.; Hillen, H.
10.1101/2024.04.04.588063 — biochemistry — Posted on 2024-04-04
3988 Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19
Canderan, G.; Muehling, L.; Kadl, A.; Ladd, S.; Bonham, C.; Cross, C.; Lima, S.; Yin, X.; Sturek, J.; Wilson, J.; Keshavarz, B.; Bryant, N.; Murphy, D.; Cheon, I. S.; McNamara, C.; Sun, J.; Utz, P. J.; Dolatshahi, S.; Irish, J.; Woodfolk, J.
10.1101/2024.04.03.587929 — immunology — Posted on 2024-04-04
3989 Analysing heterogeneity in Alzheimer Disease using multimodal normative modelling on ATN biomarkers
Kumar, S.; Earnest, T.; Yang, B.; Kothapalli, D.; Gordon, B.; Benzinger, T.; Payne, P.; Sotiras, A.
10.1101/2023.08.15.553412 — neuroscience — Posted on 2024-04-04
3991 Alternate conformational trajectories in protein synthesis
Alejo, J. L.; Girodat, D.; Hammerling, M. J.; Willi, J. A.; Jewett, M. C.; Engelhart, A. E.; Adamala, K. P.
10.1101/2024.04.03.588007 — synthetic biology — Posted on 2024-04-04
3994 Regulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15
Ebenwaldner, C.; Garcia Saura, A. G.; Ekstrom, S.; Bernfur, K.; Schuler, H.
10.1101/2024.04.04.588081 — biochemistry — Posted on 2024-04-04
3995 Human Saposin B Ligand Binding and Presentation to α-Galactosidase A
Sawyer, T. K.; Aral, E.; Staros, J. V.; Bobst, C. E.; Garman, S. C.
10.1101/2024.04.04.584535 — biochemistry — Posted on 2024-04-04
3999 Biosynthesis of oxyresveratrol in mulberry (Morus alba L.) is mediated by a group of p-coumaroyl-CoA 2'-hydroxylases acting upstream of stilbene synthases
Santiago, A.; Romero, P.; Martinez, A.; Martinez, M. J.; Echeverria, J.; Selles, S.; Alvarez-Urdiola, R.; Zhang, C.; Navarro-Paya, D.; Pizzio, G.; Mico, E.; Samper, A.; Morante, J.; Cigliano, R. A.; Manzano, D.; Bru, R.; Matus, J. T.
10.1101/2024.04.04.588114 — molecular biology — Posted on 2024-04-04
4000 Functional screening identifies novel miRNAs inhibiting Vascular Smooth Muscle Cell proliferation
Rodor, J.; Klimi, E.; Braga, L.; Ring, N. A. R.; Ballantyne, M. D.; Miscianinov, V.; Vacante, F.; Miteva, K.; Kesidou, D.; Bennett, M.; Beqqali, A.; Giacca, M.; Zacchignia, S.; Baker, A. H.
10.1101/2024.04.04.587890 — molecular biology — Posted on 2024-04-04
4001 Comparative analysis of serological assays and sero-surveillance for SARS-CoV-2 exposure in US cattle
Ramasamy, S.; Qureshi, M.; Mukherjee, S.; Mahajan, S.; LaBella, L. C.; Chothe, S. K.; Jakka, P.; Gontu, A.; Misra, S.; Surendiran-Nair, M.; Nissly, R. H.; Kuchipudi, S. V.
10.1101/2024.04.03.587933 — microbiology — Posted on 2024-04-04
4002 Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19
Lu, Y.; Yang, Q.; Ran, T.; Zhang, G.; Li, W.; Zhou, P.; Tang, J.; Dai, M.; Zhong, J.; Chen, H.; He, P.; Zhou, A.; Xue, B.; Chen, J.; Zhang, J.; Yang, S.; Wu, K.; Wu, X.; Tang, M.; Zhang, W. K.; Guo, D.; Chen, X.; Chen, H.; Shang, J.
10.1101/2024.04.03.587743 — microbiology — Posted on 2024-04-04
4003 Detection of clade 2.3.4.4b highly pathogenic H5N1 influenza virus in New York City
Meade, P. S.; Bandawane, P.; Bushfield, K.; Hoxie, I.; Azcona, K. R.; Burgos, D.; Choudhury, S.; Diaby, A.; Diallo, M.; Gaynor, K.; Huang, A.; Kante, K.; Khan, S. N.; Kim, W.; Kehinde Ajayi, P.; Roubidoux, E. K.; Nelson, S.; McMahon, R.; Albrecht, R. A.; Krammer, F.; Marizzi, C.
10.1101/2024.04.04.588061 — microbiology — Posted on 2024-04-04
4004 α-Aminooxyacetic acid derivatives acting as pro-drugs against Mycobacterium tuberculosis
Vill, K.; van Geelen, L.; Michel, O.; Kiffe-Delf, A.-L.; Berger, A.; Podlesainski, D.; Stenzel, K.; Kovacic, F.; Lungerich, B.; Burckhardt, B.; :Crooks, T. A.; Howe, M. D.; Ostrer, L.; Jia, Z.; Ioerger, T. R.; Kaschani, F.; Kaiser, M.; Baughn, A. D.; Kurz, T.; Kalscheuer, R.
10.1101/2024.04.04.587628 — microbiology — Posted on 2024-04-04
4005 European Farmhouse Brewing Yeasts Form a Distinct Genetic Group
Preiss, R.; Fletcher, E.; Garshol, L. M.; Foster, B.; Ozsahin, E.; Lubberts, M.; van der Merwe, G.; Krogerus, K.
10.1101/2024.04.04.588101 — microbiology — Posted on 2024-04-04
4007 Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaques
Xu, X.; Niu, M.; Lamberty, B. G.; Emanuel, K.; Trease, A. J.; Tabassum, M.; Lifson, J. D.; Fox, H. S.
10.1101/2024.04.04.588047 — microbiology — Posted on 2024-04-04
4008 Maturing giant kelp develop depth-specific microbiomes
Esaian, S.; Bui, A.; DiFiore, B. P.; Peters, J. R.; Lepori-Bui, M.; Moeller, H. V.; Wilbanks, E. G.
10.1101/2024.04.04.588117 — microbiology — Posted on 2024-04-04
4010 Mosquito immune cells enhance dengue and Zika virus dissemination in Aedes aegypti
Hall, D. R.; Johnson, R. M.; Kwon, H.; Ferdous, Z.; Laredo-Tiscareno, S. V.; Blitvich, B. J.; Brackney, D. E.; Smith, R. C.
10.1101/2024.04.03.587950 — microbiology — Posted on 2024-04-04
4011 LiaR-dependent gene expression contributes to antimicrobial responses in group A Streptococcus
Vega, L. A.; Sanson, M. A.; Mukherjee, P.; Morrison, G. A.; Buchan, K. D.; Hohlt, A. E.; Flores, A. R.
10.1101/2024.04.04.588141 — microbiology — Posted on 2024-04-04
4012 Investigating the biosynthesis and roles of the auxin phenylacetic acid during Pseudomonas syringae-Arabidopsis thaliana pathogenesis
Lee, C.-Y.; Harper, C. P.; Lee, S. G.; Qi, Y.; Clay, T.; Aoi, Y.; Jez, J. M.; Kasahara, H.; Blodgett, J. A. V.; Kunkel, B. N.
10.1101/2024.04.04.587729 — microbiology — Posted on 2024-04-04
4013 Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell Malignancy
Wang, X.; Cornish, A. E.; Do, M. H.; Brunner, J. S.; Hsu, T.-W.; Xu, Z.; Malik, I.; Edwards, C.; Capistrano, K. J.; Zhang, X.; Ginsberg, M. H.; Finley, L. W. S.; Lim, M. S.; Horwitz, S. M.; Li, M. O.
10.1101/2024.04.03.587917 — cancer biology — Posted on 2024-04-04
4014 Vesicle-mediated mitochondrial clearance underlies an actionable metabolic vulnerability in triple-negative breast cancer
Vykoukal, J.; Chen, Y.; Hong, M. J.; Zuo, M.; Krishna, H.; Katayama, H.; Irajizad, E.; Wu, R.; Leon-Letelier, R.; Dennison, J. B.; Gutierrez, A.; Paulucci-Holthauzen, A.; Thompson, T. C.; Rusling, L.; Cai, Y.; Hsiao, F. C.; Park, S.; Arun, B.; Hanash, S.; Fahrmann, J. F.
10.1101/2024.04.04.587899 — cancer biology — Posted on 2024-04-04
4018 Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis
Favreau, C.; Savy, C.; Bourgoin, M.; Botton, T.; Bailly, S.; Granger, F.; Birck, C.; Zerhouni, M.; Kerreneur, E.; Vigroux, A.; Dussart-Gautheret, J.; Arcangeli, M.-L.; Cluzeau, T.; Porterszman, A.; Rocchi, S.; Jacquel, A.; Benhida, R.; Auberger, P.; Martin, A. R.; Robert, G.
10.1101/2024.04.03.584800 — biochemistry — Posted on 2024-04-04
4019 The crystal structure of the Shethna Protein II (FeSII) from Azotobacter vinelandii suggests a domain swap
Kabasakal, B. V.; McFarlane, C. R.; Cotton, C. A.; Schmidt, A.; Kung, A.; Lieber, L.; Murray, J. W.
10.1101/2024.01.30.575082 — biochemistry — Posted on 2024-04-04
4023 Machine learning recognises senescence in glioblastoma and discovers senescence-inducing compounds
Martin, L.; Irving, A.; Suwanlikit, Y.; Morrison, G.; Elliott, R. J. R.; Carragher, N.; Pollard, S.; Chandra, T.
10.1101/2024.04.03.587883 — cell biology — Posted on 2024-04-04
4025 Similar, but not the same: multi-omics comparison of human valve interstitial cells and osteoblast osteogenic differentiation expanded with an estimation of data-dependent and data-independent PASEF
Lobov, A.; Kuchur, P.; Boyarskaya, N.; Perepletchikova, D.; Taraskin, I.; Ivashkin, A.; Kostina, D.; Khvorova, I.; Uspensky, V.; Repkin, E.; Denisov, E.; Gerashchenko, T.; Tikhilov, R.; Bozhkova, S.; Karelkin, V.; Wang, C.; Xu, K.; Malashicheva, A.
10.1101/2024.04.03.587893 — cell biology — Posted on 2024-04-04
4026 Discovery of a potent inhibitor that suppresses glioblastoma by dual targeting of both syntenin PDZ domains
Heo, Y.; Moon, J.; Lee, J.; Kim, M.; Ko, Y.-J.; Kim, K. H.; Yoon, K.-J.; Koo, B.-K.; Shariff, F. M.; Yun, J.-H.; Lee, W.
10.1101/2024.04.03.587914 — molecular biology — Posted on 2024-04-04
4027 Caspase cleavage of Influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production
Beale, R.; Figueras-Novoa, C.; Akutsu, M.; Murata, D.; Jiang, M.; Montaner, B.; Dubois, C.; Shenoy, A. R.
10.1101/2024.04.04.588074 — microbiology — Posted on 2024-04-04
4028 Distinct circulating monocytes up-regulate CD52 and sustain innate immune function in patients with cirrhosis unless acute decompensation emerges
Geng, A.; Brenig, R. G.; Roux, J.; Luetge, M.; Cheng, H.-W.; Flint, E. E.; Meier, M.-A.; Pop, O. T.; Kuenzler-Heule, P.; McPhail, M.; Soysal, S.; Semela, D.; Heim, M.; Weston, C. J.; Ludewig, B.; Bernsmeier, C.
10.1101/2024.04.03.587894 — immunology — Posted on 2024-04-04
4029 Caspase-8-mediated CYLD cleavage boots LPS-induced endotoxic shock.
Liu, J.; Li, M.; Xing, M.; Liu, H.; Wu, X.; Wang, L.; Li, X.; Zhao, X.; Ouyang, J.; Zhang, Y.; Li, F.; Xie, Q.; Tan, Y.; Wang, Y.; Xie, Y.; Zhang, H.; Li, H.; Li, Y.; Luo, Y.; Zhang, H.
10.1101/2024.04.03.587858 — immunology — Posted on 2024-04-04
4031 Visual imagery vividness correlates with afterimage conscious perception
Kronemer, S. I.; Holness, M.; Morgan, A. T.; Teves, J. B.; Gonzalez-Castillo, J.; Handwerker, D. A.; Bandettini, P. A.
10.1101/2023.12.07.570716 — neuroscience — Posted on 2024-04-04
4033 Advancing knowledge of West African morning glories: a taxonomic revision of Ipomoea L. (Convolvulaceae) from Ghana
Williams, B. D.; Francisco, R. C.; Mewded, B.; Oppong, C. P.; Ayensu, C. B.; Wafula, C. W.; Chukwuma, D. M.; Gadisa, D. A.; Yeboah, D. D.; Ahossou, E. O. D.; Rasaminirina, F.; Precious, I.-O. U.; Korir, M. J.; Antwi Boasiako, K. B.; Mfodwo, R. A.; Musa, M. A. S.; Junior, P. A. A.; Akomatey, P. K.; Kumordzie, S.; Borosova, R.; Tang, C.; Asase, A.; Ameka, G.; Simoes, A. R. G.
10.1101/2024.04.02.587553 — plant biology — Posted on 2024-04-04
4035 Continuous monitoring of glucose levels in vivo with a micro-organ based microfluidic biosensor
Puginier, E.; Pirog, A.; Poulletier de Gannes, F.; Gaitan, J.; Hurtier, A.; Monchablon, M.; Raoux, M.; Renaud, S.; Lang, J.
10.1101/2024.04.03.587710 — physiology — Posted on 2024-04-04
4038 Seeding competent TDP-43 persists in human patient and mouse muscle
Lynch, E. M.; Pittman, S.; Daw, J.; Ikenaga, C.; Chen, S.; Dhavale, D. D.; Jackrel, M. E.; Ayala, Y. M.; Kotzbauer, P.; Ly, C. V.; Pestronk, A.; Lloyd, T. E.; Weihl, C. C.
10.1101/2024.04.03.587918 — pathology — Posted on 2024-04-04
4040 Blended Genome Exome (BGE) as a Cost Efficient Alternative to Deep Whole Genomes or Arrays
DeFelice, M.; Grimsby, J.; Howrigan, D.; Yuan, K.; Chapman, S. B.; Stevens, C.; DeLuca, S.; Townsend, M.; Buxbaum, J.; Hertz-Picciotto, I.; Kolevzon, A.; Pericak-Vance, M. A.; Qin, S.; Stein, D.; Teferra, S.; Xavier, R.; Huang, H.; Martin, A.; Neale, B.
10.1101/2024.04.03.587209 — genomics — Posted on 2024-04-04
4041 A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti
Bacot, T.; Haberkorn, C.; Guilliet, J.; Cattel, J.; Kefi, M.; Nadalin, L.; Filee, J.; Boyer, F.; Gaude, T.; Laporte, F.; Tutagata, J.; Vontas, J.; Dusfour, I.; Bonneville, J.-M.; David, J.-P.
10.1101/2024.04.03.587871 — evolutionary biology — Posted on 2024-04-04
4043 Nuclear deformability facilitates apical nuclear migration in the developing zebrafish retina
Maia-Gil, M.; Gorjao, M.; Belousov, R.; Espina, J. A.; Coelho, J.; Ramos, A. P.; Barriga, E. H.; Erzberger, A.; Norden, C.
10.1101/2024.04.04.588091 — developmental biology — Posted on 2024-04-04
4045 Functional redundancy and formin-independent localization of tropomyosin isoforms in Saccharomyces cerevisiae
Dhar, A.; VT, B.; Biswas, S.; Kumari, J.; Sridhara, A.; Brahmendra, J. S.; Shekhar, S.; Palani, S.
10.1101/2024.04.04.587703 — cell biology — Posted on 2024-04-04
4047 The specific AMPK activator A-769662 ameliorates pathological phenotypes following mitochondrial DNA depletion
Carvalho, G.; Repoles, B.; Nguyen, T. V. H.; Forslund, J. M. E.; Ranjbarian, F.; Mendes, I. C.; Falabella, M.; Doimo, M.; Wanrooij, S.; Pitceathly, R. D.; Hofer, A.; Wanrooij, P. H.
10.1101/2024.03.14.584413 — molecular biology — Posted on 2024-04-04
4048 Unraveling interindividual differences and functional consequences of gut microbial metabolism of immunosuppressants
Baghai Arassi, M.; Karcher, N.; Mastrorilli, E.; Gross, M.; Brauer-Nikonow, A.; Hackett, R.; Czock, D.; Toenshoff, B.; Zeller, G.; Zimmermann, M.
10.1101/2024.03.28.586928 — microbiology — Posted on 2024-04-04
4051 A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition
Luppi, A. I.; Mediano, P. A. M.; Rosas, F. E.; Allanson, J.; Pickard, J. D.; Carhart-Harris, R. L.; Williams, G. B.; Craig, M. M.; Finoia, P.; Owen, A. M.; Naci, L.; Menon, D. K.; Bor, D.; Stamatakis, E. A.
10.1101/2020.11.25.398081 — neuroscience — Posted on 2024-04-04
4052 Recurrent circuits encode visual center-surround computations in the mouse superior colliculus
Cui, P.; Song, K.; Mariatos Metaxas, D.; Isla, A. G.; Femenia, T.; Lazaridis, I.; Meletis, K.; Kumar, A.; Kardamakis, A. A.
10.1101/2023.09.03.556096 — neuroscience — Posted on 2024-04-04
4053 Firing rate adaptation affords place cell theta sweeps, phase precession and procession
Chu, T.; Ji, Z.; Zuo, J.; Mi, Y.; Zhang, W.-H.; Huang, T.; Bush, D.; Burgess, N.; Wu, S.
10.1101/2022.11.14.516400 — neuroscience — Posted on 2024-04-04
4054 Sleep need driven oscillation of glutamatergic synaptic phenotype
Vogt, K.; Kulkarni, A.; Pandey, R.; Dehnad, M.; Konopka, G.; Greene, R. W.
10.1101/2024.02.05.578985 — neuroscience — Posted on 2024-04-04
4055 MCU-enriched dendritic mitochondria regulate plasticity in distinct hippocampal circuits
Pannoni, K. E.; Fischer, Q. S.; Tarannum, R.; Cawley, M. L.; Alsalman, M. M.; Acosta, N.; Ezigbo, C.; Gil, D. V.; Campbell, L. A.; Farris, S.
10.1101/2023.11.10.566606 — neuroscience — Posted on 2024-04-04
4056 Running to remember: The effects of exercise on perineuronal nets, microglia, and hippocampal angiogenesis in female and male mice
Maheu, M. G.; James, N.; Clark, Z.; Yang, A.; Patel, R.; Beaudette, S. M.; MacPherson, R. E. K.; Duarte-Guterman, P.
10.1101/2023.11.24.568577 — neuroscience — Posted on 2024-04-04
4057 Deciphering neuronal variability across states reveals dynamic sensory encoding
Akella, S.; Ledochowitsch, P.; Siegle, J. H.; Belski, H.; Denman, D. J.; Buice, M. A.; Durand, S.; Koch, C.; Olsen, S. R.; Jia, X.
10.1101/2024.04.03.587408 — neuroscience — Posted on 2024-04-04
4060 Improving bacterial metagenomic research through long read sequencing
Greenman, N. A.; Hassouneh, S. A.-D.; Abdelli, L. S.; Johnston, C.; Azarian, T.
10.1101/2023.10.31.564966 — bioinformatics — Posted on 2024-04-04
4064 Flexible communication between cell assemblies and 'reader' neurons
Pompili, M. N.; Todorova, R.; Boucly, C. J.; Leroux, E. M.; Wiener, S.; Zugaro, M.
10.1101/2022.09.06.506754 — neuroscience — Posted on 2024-04-04
4066 A common cortical basis for variations in visual crowding
Greenwood, J. A.; Jerotic, K.; Danter, J. E.; Finnie, R. J.; Schwarzkopf, D. S.
10.1101/2023.12.07.570607 — neuroscience — Posted on 2024-04-04
4068 The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance.
De Lay, N. R.; Verma, N.; Sinha, D.; Garrett, A.; Osterberg, M. K.; Reiling, S.; Porter, D.; Giedroc, D. P.; Winkler, M. E.
10.1101/2023.11.07.565944 — microbiology — Posted on 2024-04-04
4069 SlAN1 is a limiting factor for the light-dependent anthocyanin accumulation in fruit tissues of purple tomato
Reis, G. L. d.; Vaz, C. F.; Arge, L. W. P.; dos Santos, A. L.; Chaves-Silva, S.; Peres, L. E. P.; Chalfun-Junior, A.; Benedito, V. A.
10.1101/2024.04.02.587792 — plant biology — Posted on 2024-04-04
4070 Complementary environmental analysis and functional characterization of a plastid diatom lower glycolytic-gluconeogenesis pathway
Dorrell, R. G.; Zhang, Y.; Liang, Y.; Gueguen, N.; Nonoyama, T.; Croteau, D.; Penot, M.; Adiba, S.; Bailleul, B.; Gros, V.; Karlusich, J. J. P.; Zweig, N.; Fernie, A. R.; Jouhet, J.; Marechal, E.; Bowler, C.
10.1101/2022.09.08.507166 — plant biology — Posted on 2024-04-04
4076 Mosaic and cocktail capsid-virus-like particle vaccines for induction of antibodies against the EPCR-binding CIDRα1 domain of PfEMP1
Riedmiller, I. G.; Fougeroux, C.; Jensen, R. W.; Kana, I. H.; Sander, A. F.; Theander, T. G.; Lavstsen, T.; Turner, L.
10.1101/2024.04.02.587801 — immunology — Posted on 2024-04-04
4077 Radiation of pain: Psychophysical evidence of population coding mechanism
Adamczyk, W. M.; Ramu, V.; Jackson, C.; Schulze, G.; Goldschneider, K.; Kashikar-Zuck, S.; King, C.; Coghill, R. C.
10.1101/2024.04.02.587666 — neuroscience — Posted on 2024-04-04
4078 Alzheimer-related pathogenesis is dependent on neuronal receptor PTPσ.
Gu, Y.; Shu, Y.; Corona, A.; Xu, K.; Yi, A. F.; Chen, S.; Luo, M.; Tremblay, M.; Landreth, G. E.; Nelson, R.; Silver, J.; Shen, Y.
10.1101/079806 — neuroscience — Posted on 2024-04-04
4079 Expansion of pneumococcal serotype 23F and 14 lineages with genotypic changes in capsule polysaccharide locus and virulence gene profiles post introduction of pneumococcal conjugate vaccine in Blantyre, Malawi
Cave, R.; Kalizang'oma, A.; Chaguza, C.; Mwalukomo, T. S.; Kamng'ona, A.; Brown, C.; Msefula, J.; Bonomali, F.; Nyirenda, R.; Swarthout, T. D.; Kwambana-Adams, B.; French, N.; Heyderman, R. S.
10.1101/2024.03.25.586540 — microbiology — Posted on 2024-04-04
4091 A Tunable and Druggable Mechanism to Delay Forgetting of Olfactory Memories in C. elegans
Landschaft-Berliner, D.; Goldstein, K.; Teichman, G.; Anava, S.; Gingold, H.; Rieger, I.; Levy, N.; Salzberg, Y.; Pechuk, V.; Agarwal, P.; Sagi, D.; Cohen, D.; Nikelshparg, E.; Ben-Zvi, A.; Miranda-Vizuete, A.; Zaidel-Bar, R.; Oren-Suissa, M.; Rechavi, O.
10.1101/2024.04.03.587909 — neuroscience — Posted on 2024-04-03
4093 Functional reorganization of brain regions supporting non-adjacent dependency learning across the first half year of life
Cai, L.; Hakuno, Y.; Hata, M.; Hoshino, E.-i.; Arimitsu, T.; Shinohara, N.; Takahashi, T.; Watson, S.; Townsend, S.; Mueller, J. L.; Minagawa, Y.
10.1101/2024.04.03.587880 — neuroscience — Posted on 2024-04-03
4097 CINner: modeling and simulation of chromosomal instability in cancer at single-cell resolution
Dinh, K. N.; Vazquez-Garcia, I.; Chan, A.; Malhotra, R.; Weiner, A.; Mcpherson, A.; Tavare, S.
10.1101/2024.04.03.587939 — genomics — Posted on 2024-04-03
4098 APOBEC shapes tumor evolution and age at onset of lung cancer in smokers
Zhang, T.; Sang, J.; Hoang, P. H.; Zhao, W.; Rosenbaum, J.; Johnson, K. E.; Klimczak, L. J.; McElderry, J.; Klein, A.; Wirth, C.; Bergstrom, E. N.; Diaz Gay, M.; Vangara, R.; Colon-Matos, F.; Hutchinson, A.; Lawrence, S. M.; Cole, N.; Zhu, B.; Przytycka, T. M.; Shi, J.; Caporaso, N. E.; Homer, R.; Pesatori, A. C.; Consonni, D.; Imielin _ski, M.; Chanock, S. J.; Wedge, D. C.; Gordenin, D. A.; Alexandrov, L. B.; Harris, R. S.; Landi, M. T.
10.1101/2024.04.02.587805 — genomics — Posted on 2024-04-03
4102 Human receptive endometrial organoid for deciphering the implantation window
Zhang, Y.; Zhao, R.; Yang, C.; Song, J.; Liu, P.; Li, Y.; Liu, B.; Li, T.; Yin, C.; Lu, M.; Hou, Z.; Zhang, C.; Chen, Z.-J.; Wu, K.; Zhao, H.
10.1101/2023.07.27.550771 — cell biology — Posted on 2024-04-03
4103 Multi-SpinX: An Advanced Framework for Automated Tracking of Mitotic Spindles and Kinetochores in Multicellular Environments
Chai, B.; Efstathiou, C.; Choudhury, M.; Kuniyasu, K.; Jain, S. S.; Maharea, A.-C.; Tanaka, K.; Draviam, V. M.
10.1101/2024.04.03.587736 — cell biology — Posted on 2024-04-03
4106 An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans
Fryer, E.; Guha, S.; Rogel-Hernandez, L. E.; Logan-Garbisch, T.; Farah, H.; Molhoff, I. N.; Rezaei, E.; Nekimken, A. L.; Xu, A.; Seyahi, L. S.; Fechner, S.; Druckman, S.; Clandinin, T. R.; Rhee, S. Y.; Goodman, M. B.
10.1101/2023.06.02.542933 — neuroscience — Posted on 2024-04-03
4108 MCU-enriched dendritic mitochondria regulate plasticity in distinct hippocampal circuits
Pannoni, K. E.; Fischer, Q. S.; Tarannum, R.; Cawley, M. L.; Alsalman, M. M.; Acosta, N.; Ezigbo, C.; Gil, D. V.; Campbell, L. A.; Farris, S.
10.1101/2023.11.10.566606 — neuroscience — Posted on 2024-04-03
4109 Running modulates primate and rodent visual cortex differently
Liska, J. P.; Rowley, D. P.; Nguyen, T. T. K.; Muthmann, J.-O.; Butts, D. A.; Yates, J. L.; Huk, A. C.
10.1101/2022.06.13.495712 — neuroscience — Posted on 2024-04-03
4110 Metabotropic signaling within somatostatin interneurons regulates thalamocortical inputs during development
Dwivedi, D.; Dumontier, D.; Sherer, M.; Lin, S.; Mirow, A. M.; Qiu, Y.; Xu, Q.; Liebman, S. A.; Joseph, D.; Datta, S. R.; Fishell, G.; Pouchelon, G.
10.1101/2023.09.21.558862 — neuroscience — Posted on 2024-04-03
4111 Anti-manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine
Varela, R. B.; Boeschen, S. L.; Yates, N.; Houghton, T.; Blaha, C. D.; Lee, K. H.; Bennet, K. E.; Kouzani, A. Z.; Berk, M.; Quevedo, J.; Valvassori, S. S.; Tye, S. J.
10.1101/2023.07.02.547148 — neuroscience — Posted on 2024-04-03
4113 How smart was T. rex? Testing claims of exceptional cognition in dinosaurs and the application of neuron count estimates in palaeontological research
Caspar, K. R.; Gutierrez-Ibanez, C.; Bertrand, O. C.; Carr, T.; Colbourne, J.; Erb, A.; George, H.; Holtz, T. R.; Naish, D.; Wylie, D. R.; Hurlburt, G. R.
10.1101/2024.01.10.575006 — zoology — Posted on 2024-04-03
4115 Acute and sub-chronic toxicity of 6PPD-quinone to early-life stage lake trout (Salvelinus namaycush)
Roberts, C.; Lin, J.; Kohlman, E.; Jain, N.; Amekor, M.; Alcaraz, A. J.; Hogan, N.; Hecker, M.; Brinkmann, M.
10.1101/2024.03.26.586843 — physiology — Posted on 2024-04-03
4116 Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics
Walker, T. J.; Reyes-Alvarez, E.; Hyndman, B. D.; Sugiyama, M. G.; Oliveira, L. C. B.; Rekab, A. N.; Crupi, M. J. F.; Cabral-Dias, R.; Guo, Q.; Dahia, P. L. M.; Richardson, D. S.; Antonescu, C. N.; Mulligan, L. M.
10.1101/2023.06.28.546955 — cancer biology — Posted on 2024-04-03
4117 Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of the mitochondrial LONP1
Mo, A. Y.-C.; Kincross, H.; Wang, X.; Chang, L. Y.-T.; Duns, G.; Mey, F.; Zhu, Z.; Kwan, H.; Lau, T.; Docking, T. R.; Tran, J.; Colborne, S.; Cheng, S.-W. G.; Huang, S.; Gharaee, N.; Willie, E.; Jiang, J.; Parker, J.; Bridgers, J.; Wood, D.; Klein Geltink, R.; Morin, G. B.; Karsan, A.
10.1101/2022.09.10.507366 — cancer biology — Posted on 2024-04-03
4119 Human hnRNPA1 reorganizes telomere-bound Replication Protein A
Granger, S. L.; Sharma, R.; Kaushik, V.; Razzaghi, M.; Honda, M.; Gaur, P.; Bhat, D. S.; Labenz, S. M.; Heinen, J. E.; Williams, B. A.; Tabei, A.; Wlodarski, M.; Antony, E.; Spies, M.
10.1101/2023.05.09.540056 — biophysics — Posted on 2024-04-03
4121 Control of Molecular Biochemistry and Cell Injury Responses through Highly Ordered Supramolecular Assembly of Flavonoids
Reilly, C. B.; Bernier, S. G.; Shahriar, S.; Horvath, V.; Lewandowski, M.; Javorsky, E.; Budnik, B.; Ingber, D. E.
10.1101/2024.04.03.587976 — biochemistry — Posted on 2024-04-03
4123 An iron-sulfur cluster as a new metal centre in a flavodiiron protein
Martins, M. C.; Silveira, C. M.; Morgado, L.; Teixeira, M.; Folgosa, F.
10.1101/2024.04.03.587993 — biochemistry — Posted on 2024-04-03
4124 Deciphering the role of germline complex de novo structural variations in rare disorders
Jung, H.; Yang, T.-P.; Walker, S.; Danecek, P.; Salinas, I. G.; Neville, M. D. C.; Firth, H.; Scally, A.; Hurles, M.; Campbell, P.; Rahbari, R.
10.1101/2024.04.03.587925 — genomics — Posted on 2024-04-03
4125 Identification of markers for the isolation of neuron-specific extracellular vesicles
Ter-Ovanesyan, D.; Whiteman, S.; Gilboa, T.; Kowal, E. J.; Trieu, W.; Iyer, S.; Budnik, B.; Babila, C. M.; Heimberg, G.; Burgess, M. W.; Keshishian, H.; Carr, S. A.; Regev, A.; Church, G. M.; Walt, D. R.
10.1101/2024.04.03.587267 — molecular biology — Posted on 2024-04-03
4126 RNA-binding proteins identified by R-DeeP/TripepSVM are involved in heterocyst differentiation
Brenes-Alvarez, M.; Ropp, H. R.; Papagiannidis, D.; Potel, C.; Stein, F.; Savitski, M. M.; Vioque, A.; Muro-Pastor, A. M.; Hess, W. R.
10.1101/2024.04.03.587981 — molecular biology — Posted on 2024-04-03
4127 Quinoline-based compounds can inhibit diverse enzymes that act on DNA
Zhou, J.; Chen, Q.; Ren, R.; Yang, J.; Liu, B.; Horton, J. R.; Chang, C.; Li, C.; Maksoud, L.; Yang, Y.; Rotili, D.; Zhang, X.; Blumenthal, R. M.; Chen, T.; Gao, Y.; Valente, S.; Mai, A.; Cheng, X.
10.1101/2024.04.03.587980 — molecular biology — Posted on 2024-04-03
4129 Variable orthogonality of RDF-large serine integrase interactions within the phiC31 family
MacDonald, A. I.; Baksh, A.; Holland, A.; Shin, H.; Rice, P.; Stark, M. W.; Olorunniji, F. J.
10.1101/2024.04.03.587898 — molecular biology — Posted on 2024-04-03
4132 Comparative study of two Rift Valley fever virus field strains circulating in Mauritania in 2010 and 2013 reveals the high virulence of the MRU25010-30 strain isolated from camel
Chabert, M.; Lacote, S.; Marianneau, P.; Confort, M.-P.; Aurine, N.; Pedarrieu, A.; Doumbia, B.; Ould Baba Ould Gueya, M.; Habiboullah, H.; Ould El Mamy, A. B.; Lo, M. M.; Nichols, J.; Sreenu, V. B.; da Silva Filipe, A.; Colle, M.-A.; Pain, B.; Cetre-Sossah, C.; Arnaud, F.; Ratinier, M.
10.1101/2024.04.03.587352 — microbiology — Posted on 2024-04-03
4133 Telomere-to-telomere genome assembly of the clubroot pathogen Plasmodiophora brassicae
Javed, M. A.; Mukhopadhyay, S.; Normandeau, E.; Brochu, A.-S.; Perez-Lopez, E.
10.1101/2024.04.03.587992 — microbiology — Posted on 2024-04-03
4135 Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung
Holmes, C. L.; Dailey, K. G.; Hullahalli, K.; Wilcox, A. E.; Mason, S.; Moricz, B. S.; Unverdorben, L.; Waldor, M. K.; Bachman, M. A.
10.1101/2024.04.03.587919 — microbiology — Posted on 2024-04-03
4136 The stress of carrying CRISPR-Cas
Haider, D.; Bauer, R.; Grempels, A.; Roscher, R.; Aslan, C. C.; Mauerer, S.; Spellerberg, B.
10.1101/2024.04.03.587888 — microbiology — Posted on 2024-04-03
4137 Pseudovibriamides from Pseudovibrio marine sponge bacteria promote swarming motility via transcriptional modulation
Dai, Y.; Lourenzon, V.; Ioca, L. P.; Al-Smadi, D.; Arnold, L.; McIntire, I.; Berlinck, R. G.; Eustaquio, A. S.
10.1101/2024.04.03.587961 — microbiology — Posted on 2024-04-03
4142 Morphological, pathological and phylogenetic analyses identify a diverse group of Colletotrichum spp. causing leaf, pod, and flower diseases on the orphan legume African yam bean
Ogunsanya, O. M.; Adebisi, M. A.; Popoola, A. R.; Afolabi, C. G.; Oyatomi, O.; Colgan, R.; Armitage, A.; Thompson, E.; Abberton, M.; Ortega-Beltran, A.
10.1101/2024.04.03.587868 — microbiology — Posted on 2024-04-03
4143 SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides
Loreto, A.; Cramb, K. M. L.; McDermott, L. A.; Antoniou, C.; Cirilli, I.; Caiazza, M. C.; Merlini, E.; Arthur-Farra, P.; Mock, E. D.; Zhao, H. T.; Bennett, D. L.; Orsomando, G.; Coleman, M. P.; Wade-Martins, R.
10.1101/2024.04.02.587827 — neuroscience — Posted on 2024-04-03
4147 Terroir and rootstock effects on leaf shape in California Central Valley vineyards
Migicovsky, Z.; Swift, J. F.; Awale, M.; Helget, Z.; Klein, L. L.; Pinkner, L.; Woodhouse, K.; Cousins, P.; Fennell, A. Y.; Miller, A.; Chitwood, D. H.
10.1101/2024.04.02.587833 — plant biology — Posted on 2024-04-03
4150 AMRomics: a scalable workflow to analyze large microbial genome collection
Le, D. Q.; Nguyen, T. T.; Nguyen, C. H.; Ho, T. H.; Vo, N. S.; Nguyen, T.; Nguyen, H. A.; Cao, M. D.; Nguyen, S. H.
10.1101/2024.04.02.587817 — bioinformatics — Posted on 2024-04-03
4154 Dynamic land-plant carbon sources in marine sediments inferred from ancient DNA
Herzschuh, U.; Weiss, J. F.; Stoof-Leichsenring, K. F.; Harms, L.; Nuernberg, D.; Mueller, J.
10.1101/2024.04.02.587465 — ecology — Posted on 2024-04-03
4155 Lipopeptide antibiotics disrupt interactions of undecaprenyl phosphate with UptA
Oluwole, A. O.; Kalmankar, N.; Guida, M.; Bennett, J. L.; Poce, G.; Bolla, J. R.; Robinson, C. V.
10.1101/2024.04.02.587717 — molecular biology — Posted on 2024-04-03
4157 Decoding region-level visual functions from invasive EEG monkey data
Zhang, X.-Y.; Lin, H.; Deng, Z.; Siegel, M.; Miller, E. K.; Yan, G.
10.1101/2024.04.02.587853 — neuroscience — Posted on 2024-04-03
4158 Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold
Ghosh, U.; Tse, E.; Shi, M.; Yang, H.; Wang, F.; Merz, G. E.; Prusiner, S. B.; Southworth, D. R.; Condello, C.
10.1101/2024.04.02.587507 — neuroscience — Posted on 2024-04-03
4159 Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration
Liu, D.; Webber, H. C.; Bian, F.; Xu, Y.; Prakash, M.; Feng, X.; Yang, M.; Yang, H.; You, I.-J.; Li, L.; Liu, L.; Liu, P.; Huang, H.; Chang, C.-Y.; Liu, L.; Shah, S. H.; La Torre, A.; Welsbie, D. S.; Sun, Y.; Duan, X.; Goldberg, J. L.; Braun, M.; Lansky, Z.; Hu, Y.
10.1101/2024.04.02.587832 — neuroscience — Posted on 2024-04-03
4162 Three-dimensional multi-target super-resolution microscopy of cells using Metal-Induced Energy Transfer and DNA-PAINT
Oleksiievets, N.; Mougios, N.; Jans, D. C.; Hauke, L.; Thiele, J. C.; Basak, S.; Jakobs, S.; Opazo, F.; Enderlein, J.; Tsukanov, R.
10.1101/2024.04.02.587536 — biophysics — Posted on 2024-04-03
4163 Towards high-resolution modeling of small molecule-ion channel interactions
Harris, B. J.; Nguyen, P. T.; Zhou, G.; Wulff, H.; DiMaio, F.; Yarov-Yarovoy, V.
10.1101/2024.04.02.587818 — biophysics — Posted on 2024-04-03
4164 Nanopore Guided Annotation of Transcriptome Architectures
Abebe, J. S.; Alwie, Y.; Fuhrmann, E.; Leins, J.; Mai, J.; Verstraten, R.; Schreiner, S.; Wilson, A. C.; Depledge, D. P.
10.1101/2024.04.02.587744 — bioinformatics — Posted on 2024-04-03
4167 APOBEC shapes tumor evolution and age at onset of lung cancer in smokers
Zhang, T.; Sang, J.; Hoang, P.; Zhao, W.; Rosenbaum, J.; Johnson, K.; Klimczak, L.; McElderry, J.; Klein, A.; Wirth, C.; Bergstrom, E.; Diaz Gay, M.; Vangara, R.; Colon-Matos, F.; Hutchinson, A.; Lawrence, S.; Cole, N.; Zhu, B.; Przytycka, T.; Shi, J.; Caporaso, N.; Homer, R.; Pesatori, A.; Consonni, D.; Imielin _ski, M.; Chanock, S.; Wedge, D.; Gordenin, D.; Alexandrov, L.; Harris, R.; Landi, M.
10.1101/2024.04.02.587805 — genomics — Posted on 2024-04-03
4168 Genome-Wide Association Insights into the Genomic Regions Controlling Oil Production Traits in Acrocomia aculeata (neotropical native palm)
Couto, E. G. d. O.; Morales-Marroquin, J.; Alves-Pereira, A.; Fernandes, S. B.; Colombo, C. A.; Azevedo-Filho, J.; Carvalho, C. R. L.; Zucchi, M. I.
10.1101/2024.01.17.576138 — genetics — Posted on 2024-04-03
4170 Resilience in a time of stress: revealing the molecular underpinnings of coral survival following thermal bleaching events
Nunn, B. L.; Brown, T.; Timmins-Schiffman, E. B.; Mudge, M.; Riffle, M.; Axworthy, J.; Dilwort, J.; Kenkel, C. D.; Zaneveld, J.; Rodrigues, L.; Padilla-Gamino, J. R.
10.1101/2024.04.02.587798 — ecology — Posted on 2024-04-03
4171 Native molecular architectures of centrosomes in C. elegans embryos
Tollervey, F.; Rios, M. U.; Zagoriy, E.; Woodruff, J. B.; Mahamid, J.
10.1101/2024.04.03.587742 — cell biology — Posted on 2024-04-03
4175 Exploring thermal tolerance across time and space in a tropical bivalve, Pinctada margaritifera
Lugue, K.; Monaco, C.; Erwan, V.; Sham Koua, M.; Vidal-Dupiol, J.; Mitta, G.; Le Luyer, J.
10.1101/2024.04.02.587172 — physiology — Posted on 2024-04-03
4176 Conditional deletion of CEACAM1 causes hepatic stellate cell activation
Muturi, H. T.; Ghadieh, H. E.; Asalla, S.; Lester, S. G.; Verhulst, S.; Stankus, H. L.; Zaidi, S.; Abdolahipour, R.; Belew, G. D.; Grunsven, L. A. v.; Friedman, S. L.; Schwabe, R. F.; Hinds, T. D.; Najjar, S. M.
10.1101/2024.04.02.586238 — physiology — Posted on 2024-04-03
4178 Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase
Singh, R.; Jiang, R.; Williams, J.; Dobariya, P.; Hanak, F.; Xie, J.; Rothwell, P. E.; Vince, R.; More, S.
10.1101/2024.04.02.587756 — pharmacology and toxicology — Posted on 2024-04-03
4179 Detection of changes in membrane potential by magnetic resonance imaging
Min, K.; Chung, S.; Lee, S.-K.; Lee, J.; Toi, P. T.; Kim, D.; Lee, J. S.; Park, J.-Y.
10.1101/2024.04.02.587661 — biophysics — Posted on 2024-04-03
4185 Rapid small-scale nanobody-assisted purification of ryanodine receptors for cryo-EM
Li, C.; Willegems, K.; Uchanski, T.; Pardon, E.; Steyaert, J.; Efremov, R. G.
10.1101/2024.04.03.587959 — biochemistry — Posted on 2024-04-03
4186 Chromosome-level genome assembly of the loach goby, Rhyacichthys aspro, reveals mechanisms underlying Gobioidei diversification
Wang, T.-Y.; Lu, H.-J.; Wu, Y.-W.; Liao, T.-Y.; Huang, S.-P.; Wang, F.-Y.; Ting, C.-T.; Chaw, S.-M.; Wang, H.-Y.
10.1101/2024.04.02.587698 — genomics — Posted on 2024-04-03
4187 XOL-1 regulates developmental timing by modulating the H3K9 landscape in C. elegans early embryos
Jash, E.; Azhar, A. A.; Mendoza, H.; Tan, Z. M.; Escher, H. N.; Kaufman, D. S.; Csankovszki, G.
10.1101/2024.04.02.587675 — genetics — Posted on 2024-04-03
4188 Impact of three light smoltification regimes on performance and genetic parameters of traits in Atlantic salmon
Gjerde, B.; Boison, S. A.; Hazlerigg, D.; Ytrestoyl, T.; Morkore, T.; Jorgensen, E.; Striberny, A.; Sandve, S. R.
10.1101/2024.04.02.587721 — genetics — Posted on 2024-04-03
4190 A large-scale and long-term experiment to identify effectiveness of ecosystem restoration
Elo, M.; Kareksela, S.; Ovaskainen, O.; Abrego, N.; Niku, J.; Taskinen, S.; Aapala, K.; Kotiaho, J. S.
10.1101/2024.04.02.587693 — ecology — Posted on 2024-04-03
4192 Electric charge controls plasmodesma conductivity
Knoblauch, M.; Christensen, A. H.; Howell, A. H.; James, V.; Jensen, K. H.; Vasina, V. V.; Foley, J.; Evans, J. E.; Stone, H. A.; Peters, W. S.
10.1101/2024.04.02.587779 — cell biology — Posted on 2024-04-03
4194 A species difference in glycerol-3-phosphate metabolism reveals metabolic adaptations in hares
Gaertner, K.; Terzioglu, M.; Michell, C.; Tapanainen, R.; Pohjoismäki, J. L. O.; Dufour, E.; Saari, S.
10.1101/2024.04.02.587662 — molecular biology — Posted on 2024-04-03
4195 Cell-specific polymerization-driven biomolecular condensate formation fine-tunes root tissue morphogenesis
Su, J.; Xu, X.; Cseke, L.; Whittier, S.; Zhou, R.; Zhang, Z.; Dietz, Z.; Singh, K.; Yang, B.; Chen, S.-Y.; Picking, W.; Zou, X.; Gassmann, W.
10.1101/2024.04.02.587845 — molecular biology — Posted on 2024-04-03
4197 Downregulation of Semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis
Kume, M.; Koguchi-Yoshioka, H.; Nakai, S.; Matsumura, Y.; Tanemura, A.; Yokoi, K.; Matsuda, S.; Nakamura, Y.; Otani, N.; Taminato, M.; Tomita, K.; Kubo, T.; Wataya-Kaneda, M.; Kumanogoh, A.; Fujimoto, M.; Watanabe, R.
10.1101/2024.04.02.587777 — immunology — Posted on 2024-04-03
4198 Dynamic neuroinflammatory profiles predict Alzheimer's disease pathology in microglia-containing cerebral organoids
Kuhn, M. K.; Kang, R. Y.; Kim, C.; Tagay, Y.; Morris, N.; Tabdanov, E. D.; Elcheva, I. A.; Proctor, E. A.
10.1101/2023.11.16.567220 — neuroscience — Posted on 2024-04-03
4199 Genomic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats
King, C. P.; Chitre, A. S.; Leal-Gutierrez, J. D.; Tripi, J. A.; Hughson, A.; Horvath, A.; Lamparelli, A. C.; George, A.; Martin, C.; St. Pierre, C. L.; Sanches, T.; Bimschleger, H. V.; Gao, J.; Cheng, R.; Nguyen, K.-M.; Holl, K. L.; Polesskaya, O.; Ishiwari, K.; Chen, H.; Solberg Woods, L. C.; Palmer, A. A.; Robinson, T. E.; Flagel, S. B.; Meyer, P. J.
10.1101/2024.03.13.584852 — neuroscience — Posted on 2024-04-03
4202 A simple framework for agent-based modeling with extracellular matrix
Metzcar, J.; Duggan, B. S.; Fischer, B.; Murphy, M.; Heiland, R.; Macklin, P.
10.1101/2022.11.21.514608 — systems biology — Posted on 2024-04-03
4203 Cheap, Robust and Versatile Two-Dimensional Chromatography system for Proteomics of Nanogram Scale Samples
Kitano, E.; Nisbet, G.; Demyanenko, Y.; Kowalczyk, K.; Cross, S.; Iselin, L.; Castello, A.; Mohammed, S.
10.1101/2024.04.02.587751 — systems biology — Posted on 2024-04-03
4206 Human Recombinant Thyrotropin Fails to Induce Thyroid Cell Proliferation
Kalampounias, G.; Varemmenou, A.; Aronis, C.; Mamali, I.; Shaukat, A.-N.; Chartoumpekis, D.; Katsoris, P.; Michalaki, M.
10.1101/2024.04.02.587718 — cancer biology — Posted on 2024-04-03
4207 Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T cell receptor signalling.
Armstrong, E.; Chiu, M. K. L.; Foo, S.; Appleton, L.; Nenclares, P.; Patrikeev, A.; Mohan, N.; McLaughlin, M.; Bozhanova, G.; Hoebart, J.; Roulstone, V.; Patin, E. C.; Pedersen, M.; Kyula, J.; Errington-Mais, F.; Bell, J. C.; Harrington, K. J.; Melcher, A. A.; Jennings, V. A.
10.1101/2024.04.02.587705 — cancer biology — Posted on 2024-04-03
4208 Regulation of fatty acid delivery to metastases by tumor endothelium
Edwards, D. N.; Wang, S.; Song, W.; Kim, L. C.; Ngwa, V. M.; Hwang, Y.; Ess, K. C.; Boothby, M. R.; Chen, J.
10.1101/2024.04.02.587724 — cancer biology — Posted on 2024-04-03
4209 Plasticity and Dynamics of Hematopoietic Cells within Bone Marrow Microenvironment in Leukemia
Wei, C.; Xiong, S.; Zhou, Y.; Dong, L.; Yu, P.; Tang, Y.; Zhou, R.; Ni, B.; Hou, J.; Liu, G.; Cheng, L.
10.1101/2024.04.02.587680 — bioinformatics — Posted on 2024-04-03
4211 Completion of the DrugMatrix Toxicogenomics Database using ToxCompl
Cong, G.; Patton, R. M.; Chao, F.; Svoboda, D. L.; Casey, W. M.; Schmitt, C. P.; Murphy, C.; Erickson, J. N.; Combs, P.; Auerbach, S. S.
10.1101/2024.03.26.586669 — genomics — Posted on 2024-04-03
4215 Dynamic Tracking of Native Polyclonal Hematopoiesis in Adult Mice
Liu, S.; Adams, S. E.; Zheng, H.; Ehnot, J.; Jung, S. K.; Jeffrey, G.; Menna, T.; Purton, L.; Lee, H.; Kurre, P.
10.1101/2024.04.02.587737 — cell biology — Posted on 2024-04-03
4216 Extracellular electrophysiology on clonal human beta-cell spheroids
Puginier, E.; Leal Fischer, K.; Gaitan, J.; Lallouet, M.; Scotti, P.-A.; Raoux, M.; Lang, J.
10.1101/2024.04.02.587706 — cell biology — Posted on 2024-04-03
4217 Potassium rhythms couple the circadian clock to the cell cycle
Gil Rodriguez, S.; Crosby, P.; Hansen, L. L.; Grunewald, E.; Beale, A. D.; Spangler, R. K.; Rabbitts, B. M.; Partch, C. L.; Stangherlin, A.; O'Neill, J. S.; van Ooijen, G.
10.1101/2024.04.02.587153 — cell biology — Posted on 2024-04-03
4218 The flavivirus protein NS4B recruits the cis-Golgi protein ACBD3 to modify ER-Golgi trafficking for virion release
Yau, W.-L.; Peters, M. B. A.; Sorin, M.; Ronfeldt, S.; Pulkkinen, L. I. A.; Carlson, L.-A.; Overby, A. K.; Lundmark, R.
10.1101/2024.04.03.587877 — cell biology — Posted on 2024-04-03
4219 Airway injury induces alveolar epithelial and mesenchymal responses mediated by macrophages
Wong, I. G.; Stark, J.; Ya, V.; Moye, A. L.; Vazquez, A. B.; Dang, S. M.; Shehaj, A.; Rouhani, M. J.; Bronson, R.; Janes, S. M.; Rowbotham, S. P.; Paschini, M.; Franklin, R. A.; Kim, C. F.
10.1101/2024.04.02.587596 — cell biology — Posted on 2024-04-03
4220 The kinesin motor Kif9 regulates centriolar satellite positioning and mitotic progression.
Vicente, J. J.; Wagenbach, M.; Decarreau, J.; Zelter, A.; MacCoss, M. J.; Davis, T.; Wordeman, L.
10.1101/2024.04.03.587821 — cell biology — Posted on 2024-04-03
4222 Antibody-dependent Intracellular neutralisation by TRIM21 is potentiated by HOIP and linear ubiquitin chains
Green, C. S.; Winklhofer, K. F.; Fletcher, A. J.; James, L. C.; Skidmore, J.; Duce, J.; McEwan, W. A.
10.1101/2024.04.02.587719 — immunology — Posted on 2024-04-03
4223 Disease diagnostics using machine learning of immune receptors
Zaslavsky, M. E.; Craig, E.; Michuda, J. K.; Sehgal, N.; Ram-Mohan, N.; Lee, J.-Y.; Nguyen, K. D.; Hoh, R. A.; Pham, T. D.; Röltgen, K.; Lam, B.; Parsons, E. S.; Macwana, S. R.; DeJager, W.; Drapeau, E. M.; Roskin, K. M.; Cunningham-Rundles, C.; Moody, M. A.; Haynes, B. F.; Goldman, J. D.; Heath, J. R.; Nadeau, K. C.; Pinsky, B. A.; Blish, C. A.; Hensley, S. E.; Jensen, K.; Meyer, E.; Balboni, I.; Utz, P. J.; Merrill, J. T.; Guthridge, J. M.; James, J. A.; Yang, S.; Tibshirani, R.; Kundaje, A.; Boyd, S. D.
10.1101/2022.04.26.489314 — immunology — Posted on 2024-04-03
4224 Microvascular immunity is organ-specific and concealed in peripheral blood
Rixen, R.; Schuetz, P.; Walter, C.; Huechtmann, B.; Van Marck, V.; Heitplatz, B.; Varghese, J.; Pavenstaedt, H.; Buscher, K.
10.1101/2024.04.02.584356 — immunology — Posted on 2024-04-03
4225 Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools
Biderman, D.; Whiteway, M. R.; Hurwitz, C.; Greenspan, N. R.; Lee, R. S.; Vishnubhotla, A.; Schartner, M.; Huntenburg, J. M.; Khanal, A.; Meijer, G. T.; Noel, J.-P.; Pan-Vazquez, A.; Socha, K. Z.; Urai, A. E.; The International Brain Laboratory, ; Warren, R.; Noone, D.; Pedraja, F.; Cunningham, J.; Sawtell, N. B.; Paninski, L.
10.1101/2023.04.28.538703 — neuroscience — Posted on 2024-04-03
4227 Targeting the Atypical Chemokine Receptor 2 (ACKR2) improves the benefit of anti-PD-1 immunotherapy in melanoma
Noman, M. Z.; Szpakowska, M.; Xiao, M.; Van Moer, K.; Ollert, M.; Berchem, G.; Chevigne, A.; Janji, B.
10.1101/2024.04.02.587761 — cancer biology — Posted on 2024-04-03
4230 Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data
Lee, Y.; Chen, E. L. Y.; Chan, D. C. H.; Dinesh, A.; Afiuni-Zadeh, S.; Klamann, C.; Selega, A.; Mrkonjic, M.; Jackson, H. W.; Campbell, K. R.
10.1101/2024.02.29.582827 — bioinformatics — Posted on 2024-04-03
4233 FHOD-1/profilin-mediated actin assembly protects sarcomeres against contraction-induced deformation in C. elegans
Kimmich, M. J.; Sundaramurthy, S.; Geary, M. A.; Lesanpezeshki, L.; Yingling, C. V.; Vanapalli, S. A.; Littlefield, R. S.; Pruyne, D.
10.1101/2024.02.29.582848 — cell biology — Posted on 2024-04-03
4236 GLP1R agonists activate human POMC neurons
Mazzaferro, S.; Chen, H.-J. C.; Cahn, O.; Yang, A.; Shepilov, D.; Chen, J.; Alcaino, C.; Macarelli, V.; Mali, I.; Gribble, F.; Reimann, F.; Marioni, J.; Merkle, F. T.
10.1101/2024.04.02.587825 — neuroscience — Posted on 2024-04-03
4240 Serum from patients with Idiopathic inflammatory myopathy induces skeletal muscle weakness
Leijding, C.; Andreasson, K. M.; Horuluoglu, B.; Feria, A. S. G.; Van Gompel, E.; Dastmalchi, M.; Gastaldello, S.; Alexanderson, H.; Lundberg, I. E.; Andersson, D. C.
10.1101/2024.04.02.587168 — physiology — Posted on 2024-04-03
4241 Structure and function of an intermediate GPCR-G protein complex
Bi, M.; Wang, X.; Wang, J.; xu, J.; Sun, W.; Adediwrua, V. A.; Miao, Y.; Cheng, Y.; Ye, L.
10.1101/2024.04.02.587841 — biophysics — Posted on 2024-04-03
4242 CLigOpt: Controllable Ligand Design through Target-Specific Optimisation
Li, Y.; da Costa Avelar, P. H.; Chen, X.; Zhang, L.; Wu, M.; Tsoka, S.
10.1101/2024.03.15.585255 — bioinformatics — Posted on 2024-04-03
4246 A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function
Ganga, A. K.; Sweeney, L. K.; Rubio-Ramos, A.; Bishop, C. S.; Hamel, V.; Guichard, P.; Breslow, D. K.
10.1101/2024.04.02.587836 — cell biology — Posted on 2024-04-03
4247 Cell-specific polymerization-driven biomolecular condensate formation fine-tunes root tissue morphogenesis
Gassmann, W.; Su, J.; Xu, X.; Cseke, L.; Whittier, S.; Zhou, R.; Zhang, Z.; Dietz, Z.; Singh, K.; Yang, B.; Chen, S.-Y.; Picking, W.; Zou, X.
10.1101/2024.04.02.587845 — molecular biology — Posted on 2024-04-03
4252 Finding Antibodies in Cryo-EM densities with CrAI
Mallet, V.; Rapisarda, C.; Minoux, H.; Ovsjanikov, M.
10.1101/2023.09.27.559736 — bioinformatics — Posted on 2024-04-03
4257 Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome
Alvino, F.-G.; Gini, S.; Minetti, A.; Pagani, M.; Sastre-Yague, D.; Barsotti, N.; De Guzman, E.; Schleifer, C.; Stuefer, A.; Kushan, L.; Montani, C.; Galbusera, A.; Papaleo, F.; Lombardo, M.-V.; Pasqualetti, M.; Bearden, C. E.; Gozzi, A.
10.1101/2024.03.29.587339 — neuroscience — Posted on 2024-04-03
4258 Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9 with functional confirmation
Palomino, S. M.; Gabriel, K.; Mwirigi, J.; Cervantes, A.; Horton, P.; Funk, G.; Moutal, A.; Martin, L.; Khanna, R.; Price, T. J.; Patwardhan, A.
10.1101/2024.04.02.587857 — neuroscience — Posted on 2024-04-03
4260 DNA-free and genotype-independent CRISPR/Cas9 system in soybean
Kuwabara, C.; Miki, R.; Maruyama, N.; Yasui, M.; Hamada, H.; Nagira, Y.; Imai, R.; Taoka, N.; Yamada, T.
10.1101/2024.04.02.587856 — plant biology — Posted on 2024-04-03
4262 Chromosome-scale genome assembly the tropical abalone (Haliotis asinina)
Barkan, R.; Cooke, I. R.; Watson, S.-A.; Lau, S. C. Y.; Strugnell, J. M.
10.1101/2024.04.02.587722 — genomics — Posted on 2024-04-03
4263 7,8-Dihydroxyflavone is a direct inhibitor of pyridoxal phosphatase
Brenner, M.; Zink, C.; Witzinger, L.; Keller, A.; Hadamek, K.; Bothe, S.; Neuenschwander, M.; Villmann, C.; von Kries, J. P.; Schindelin, H.; Jeanclos, E.; Gohla, A.
10.1101/2023.10.04.560852 — biochemistry — Posted on 2024-04-03
4264 Large-scale composite hypothesis testing for omics analyses.
De Walsche, A.; Gauthier, F.; Charcosset, A.; Mary-Huard, T.
10.1101/2024.03.17.585412 — genomics — Posted on 2024-04-03
4267 Deciphering Bacterial and Archaeal Transcriptional Dark Matter and Its Architectural Complexity
Mattick, J. S. A.; Bromley, R. E.; Watson, K. J.; Adkins, R. S.; Holt, C. I.; Lebov, J. F.; Sparklin, B. C.; Tyson, T. S.; Rasko, D. A.; Hotopp, J. C. D.
10.1101/2024.04.02.587803 — genomics — Posted on 2024-04-03
4268 A deep learning framework for automated and generalized synaptic event analysis
O'Neill, P. S.; Baccino-Calace, M.; Rupprecht, P.; Friedrich, R. W.; Mueller, M.; Delvendahl, I.
10.1101/2023.11.02.565316 — neuroscience — Posted on 2024-04-03
4270 Heat stress impairs centromere structure and segregation of meiotic chromosomes in Arabidopsis
Crhak Khaitova, L.; Mikulkova, P.; Pecinkova, J.; Kalidass, M.; Heckmann, S.; Lermontova, I.; Riha, K.
10.1101/2023.04.19.537519 — plant biology — Posted on 2024-04-03
4271 Safety and efficacy study of CRISPR/Cas9 treatment of sickle cell disease in clinically relevant conditions highlights disease-specific response
Frati, G.; Brusson, M.; Sartre, G.; MLAYAH, B.; FELIX, T.; Chalumeau, A.; Antoniou, P.; Hardouin, G.; Concordet, J.-P.; Romano, O.; Turchiano, G.; Miccio, A.
10.1101/2024.01.14.575586 — bioengineering — Posted on 2024-04-03
4272 Diverse Database and Machine Learning Model to narrow the generalization gap in RNA structure prediction
de Lajarte, A.; Martin des Taillades, Y.; Kalicki, C.; Fuchs, F.; Aruda, J.; Salazar, D.; Allan, M.; L'Esperance-Kerckhoff, C.; Kashi, A.; Jossinet, F.; Rouskin, S.
10.1101/2024.01.24.577093 — biochemistry — Posted on 2024-04-03
4275 Predicting the dynamic interaction of intrinsically disordered proteins
Zheng, Y.; Li, Q.; Freiberger, M. I.; Song, H.; Hu, G.; Zhang, M.; Gu, R.; Li, J.
10.1101/2023.12.04.569847 — molecular biology — Posted on 2024-04-03
4276 BetaAlign: a deep learning approach for multiple sequence alignment
Dotan, E.; Wygoda, E.; Ecker, N.; Alburquerque, M.; Avram, O.; Belinkov, Y.; Pupko, T.
10.1101/2024.03.24.586462 — bioinformatics — Posted on 2024-04-03
4278 ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial to mesenchymal transition in cranial neural crest lineage commitment
Barnada, S.; Giner De Garcia, A.; Morenilla-Palao, C.; Lopez-Cascales, M.-T.; Scopa, C.; Waltrich, F.; Mikkers, H.; Cicardi, M. E.; Karlin, J.; Trotti, D.; Peterson, K.; Brugmann, S. A.; Santen, G.; McMahon, S.; Herrera, E.; Trizzino, M.
10.1101/2024.04.03.587869 — developmental biology — Posted on 2024-04-03
4279 Visual mental imagery in typical imagers and in aphantasia: A millimeter-scale 7-T fMRI study
Liu, J.; Zhan, M.; Hajhajate, D.; Spagna, A.; Dehaene, S.; Cohen, L.; Bartolomeo, P.
10.1101/2023.06.14.544909 — neuroscience — Posted on 2024-04-03
4282 Depletion of membrane cholesterol modifies structure, dynamic and activation of Nav1.7
Albani, S.; Eswaran, V. S. B.; Piergentili, A.; Souza, P. C. T. d.; Lampert, A.; Rossetti, G.
10.1101/2024.02.21.581348 — physiology — Posted on 2024-04-03
4283 COA8 is a COX10-binding protein involved in the early biogenesis of cytochrome c oxidase
Brischigliaro, M.; Cunatova, K.; Cabrera-Orefice, A.; Pei, J.; Franchin, C.; Roverso, M.; Povea-Cabello, S.; Bogialli, S.; Arrigoni, G.; Arnold, S.; Cong, Q.; Zeviani, M.; Viscomi, C.; Fernandez-Vizarra, E.
10.1101/2024.04.02.587738 — biochemistry — Posted on 2024-04-03
4286 Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process
Zhang, C.; Ren, T.; Zhao, X.; Su, Y.; Wang, Q.; Zhang, T.; He, B.; Wu, L.-Y.; Sun, L.; Zhang, B.; Xia, Z.
10.1101/2024.04.01.587649 — immunology — Posted on 2024-04-03
4288 Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking
el Azhar, Y.; Schulthess, P.; van Oostrom, M. J.; Meijer, W. H. M.; Thomas, W. M.; Bauer, M.; Sonnen, K. F.
10.1101/2024.03.30.586691 — developmental biology — Posted on 2024-04-02
4289 An immunohistochemical atlas of necroptotic pathway expression
Chiou, S.; Al-Ani, A.; Pan, Y.; Patel, K.; Kong, I.; Whitehead, L.; Light, A.; Young, S.; Barrios, M.; Sargeant, C.; Rajasekhar, P.; Zhu, L.; Hempel, A.; Lin, A.; Rickard, J.; Hall, C.; Gangatirkar, P.; Yip, R.; Cawthorne, W.; Jacobsen, A.; Horne, C.; Martin, K. R.; Ioannidis, L.; Hansen, D.; Day, J.; Wicks, I.; Law, C. W.; Ritchie, M. E.; Bowden, R.; Hildebrand, J.; O'Reilly, L.; Silke, J.; Giulino-Roth, L.; Tsui, E.; Rogers, K.; Hawkins, E.; Christensen, B.; Murphy, J. M.; Samson, A. L.
10.1101/2023.10.31.565039 — cell biology — Posted on 2024-04-02
4291 Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress
Sun, L.; Chen, X.; Shi, W.; Song, C.; Liu, L.; Bai, S.; Wang, X.; Chen, J.; Jiang, C.; Wang, S.-m.; Luo, Z.-q.; Wang, Y.; Jin, Q.-w.
10.1101/2024.04.02.587770 — cell biology — Posted on 2024-04-03
4292 Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks
Gu, S.; Shao, Z.; Qu, Z.; Zhu, S.; Shao, Y.; Zhang, D.; Allen, R.; He, R.; Shao, J.; Xiong, G.; Jousset, A.; Friman, V.-P.; Wei, Z.; Kuemmerli, R.; Li, Z.
10.1101/2023.11.05.565711 — microbiology — Posted on 2024-04-02
4294 Cognitive Phenotype Shifts in Risk-Taking: Interplay of Non-Suicidal Self-Injury Behaviors and Intensified Depression
Lu, Y.-L.; Ge, Y.; Li, M.; Liang, S.; Zhang, X.; Sui, Y.; Yang, L.; Li, X.; Zhang, Y.; Zhang, H.; Yan, H.
10.1101/2023.12.10.570987 — neuroscience — Posted on 2024-04-02
4295 PFAS assessment in fish: samples from Illinois waters
Wang, X.; Sands, M.; Jensen, T.; La Frano, M.; Lin, M.; Irudayaraj, J.
10.1101/2023.08.29.555412 — pharmacology and toxicology — Posted on 2024-04-02
4298 Near telomere-to-telomere genome assemblies of two Chlorella species unveil the composition and evolution of centromeres in green algae
Wang, B.; Jia, Y.; Dang, N.; Yu, J.; Bush, S. J.; Gao, S.; He, W.; Wang, S.; Guo, H.; Yang, X.; Ma, W.; Ye, K.
10.1101/2024.02.27.582245 — genomics — Posted on 2024-04-02
4299 Bacterial sepsis triggers stronger transcriptomic immune responses in larger primates
McMinds, R.; Jiang, R. H.; Adapa, S. R.; Cornelius Ruhs, E.; Munds, R. A.; Leiding, J. W.; Downs, C.; Martin, L. B.
10.1101/2023.07.11.548565 — evolutionary biology — Posted on 2024-04-02
4304 Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome.
Lopes, F. M.; Grenier, C.; Jarvis, B. W.; Al Mahdy, S.; Lene-Mckay, A.; Gurney, A. M.; Newman, W. G.; Waddington, S. N.; Woolf, A. S.; Roberts, N. A.
10.1101/2023.07.03.547034 — neuroscience — Posted on 2024-04-02
4305 Reconstruction of single cell lineage trajectories and identification of diversity in fates during the epithelial-to-mesenchymal transition
Cheng, Y.-C.; Zhang, Y.; Tripathi, S.; BV, H.; Jolly, M. K.; Schiebinger, G.; Levine, H.; McDonald, T. O.; Michor, F.
10.1101/2023.09.19.558325 — systems biology — Posted on 2024-04-02
4306 ComPRePS: An Automated Cloud-based Image Analysis tool to democratize AI in Digital Pathology
Mimar, S.; Paul, A. S.; Lucarelli, N.; Boarder, S.; Santo, B. A.; Naglah, A.; Barisoni, L.; Hodgin, J.; Rosenberg, A.; Clapp, W.; Sarder, P.; for the Kidney Precision Medicine Project,
10.1101/2024.03.21.586102 — pathology — Posted on 2024-04-02
4307 Empowering STEM Students: A University-wide Mentorship Program Fostering Retention and Belonging
Ravishankar, S.; Spencer-Drakes, T. C. J.; Fernandes, I. H.; Hayes, M. I.; Coopwood, S.; Spencers, I.; Neal, S. E.
10.1101/2024.04.02.587784 — scientific communication and education — Posted on 2024-04-02
4309 Cas9 RNP Physiochemical Analysis for Enhanced CRISPR-AuNP Assembly and Function
Lane, D. D.; Gottimukkala, K. S. V.; Cunningham, R.; Cassidy, M. E.; Jwa, Y.; Castelli, J. M. P.; Adair, J. E.
10.1101/2024.04.02.586657 — bioengineering — Posted on 2024-04-02
4310 COA8 is a COX10-binding protein involved in the early biogenesis of cytochrome c oxidase
Fernandez-Vizarra, E.; Brischigliaro, M.; Cunatova, K.; Cabrera-Orefice, A.; Pei, J.; Franchin, C.; Roverso, M.; Povea-Cabello, S.; Bogialli, S.; Arrigoni, G.; Arnold, S.; Cong, Q.; Zeviani, M.; Viscomi, C.
10.1101/2024.04.02.587738 — biochemistry — Posted on 2024-04-02
4311 Cryo-EM insight into hydrogen positions and water networks in photosystem II
Hussein, R.; Graca, A. T.; Forsman, J.; Aydin, O. A.; Hall, M.; Gaetcke, J.; Chernev, P.; Wendler, P.; Dobbek, H.; Messinger, J.; Zouni, A.; Schroder, W. P.
10.1101/2024.04.02.586245 — biochemistry — Posted on 2024-04-02
4312 DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids
Dearlove, E. L.; Chatrin, C.; Buetow, L.; Ahmed, S. F.; Schmidt, T.; Bushell, M.; Smith, B. O.; Huang, D. T.
10.1101/2024.04.02.587769 — biochemistry — Posted on 2024-04-02
4315 Development of BODIPY-based fluorescent probes for highly selective amino acid identification
Hendrick, N.; Martin, A.; Chan, A.; Lenihan, J.; Reiter, H.; Clough, M.; Jiang, L.; Whaley, E.; Jeong Huh, Y.; McNeely, J.; Chen, A.; Emili, A.; Beeler, A. B.
10.1101/2024.04.02.587799 — biochemistry — Posted on 2024-04-02
4320 Distal Protein-Protein Interactions Contribute to SARS-CoV-2 Main Protease Substrate Binding and Nirmatrelvir Resistance
Lewandowski, E. M.; Zhang, X.; Tan, H.; Jaskolka-Brown, A.; Kohaal, N.; Frazier, A.; Madsen, J. J.; Jacobs, L. M. C.; Wang, J.; Chen, Y.
10.1101/2024.04.01.587566 — molecular biology — Posted on 2024-04-02
4321 Evolutionary insights into the emergence of virulent Leptospira spirochetes
Giraud-Gatineau, A.; Nieves, C.; Harrison, L.; Benaroudj, N.; Veyrier, F. J.; Picardeau, M.
10.1101/2024.04.02.587687 — microbiology — Posted on 2024-04-02
4322 Cytosolic factors controlling PASTA kinase-dependent ReoM phosphorylation
Rothe, P.; Wamp, S.; Rosemeyer, L.; Rismondo, J.; Doellinger, J.; Grundling, A.; Halbedel, S.
10.1101/2024.04.02.587704 — microbiology — Posted on 2024-04-02
4323 Multilayered interaction between CRISPR-Cas subtype I-A and adjacently encoded Acrs of virus SIRV2
Bhoobalan-Chitty, Y.; Dwiputra, N.; Mayo-Munoz, D.; Baadsgaard, K.; Detlefsen, M. R. K. S.; Peng, X.
10.1101/2024.04.02.587611 — microbiology — Posted on 2024-04-02
4324 Microbial ecology and site characteristics underlie differences in salinity-methane relationships in coastal wetlands
Bueno de Mesquita, C. P.; Hartman, W. H.; Ardon, M.; Bernhardt, E. S.; Neubauer, S. C.; Weston, N. B.; Tringe, S. G.
10.1101/2024.04.02.587477 — microbiology — Posted on 2024-04-02
4325 Analysis of predation-driven inoculum loss and carbon flow in bioaugmented soils through DNA-SIP
Nieto, E. E.; Jurburg, S. D.; Steinbach, N.; Festa, S.; Morelli, I. S.; Coppotelli, B.; Chatzinotas, A.
10.1101/2024.04.02.587735 — microbiology — Posted on 2024-04-02
4327 HIV-1 Vpr causes separate cell cycle arrests in G2 and M that activate alternative DNA damage pathways
Hall, R.; Ahern, L. M.; Yap, M. W.; Tsai, M.-H. C.; Boucherit, V. C.; Takaki, T.; Boulton, S. J.; Bishop, K. N.
10.1101/2024.04.02.587683 — microbiology — Posted on 2024-04-02
4329 Polar confinement of a macromolecular machine by an SRP-type GTPase
Dornes, A.; Schmidt, L. M.; Mais, C.-N.; Hook, J. C.; Pane-Farre, J.; Kressler, D.; Thormann, K.; Bange, G.
10.1101/2024.04.02.587688 — microbiology — Posted on 2024-04-02
4330 Mapping immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans
Addetia, A.; Stewart, C.; Seo, A. J.; Sprouse, K. R.; Asiri, A. Y.; Al-Mozaini, M.; Memish, Z. A.; Alshukairi, A.; Veesler, D.
10.1101/2024.03.31.586409 — immunology — Posted on 2024-04-02
4331 Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process
Xia, Z.; Zhang, B.; Sun, L.; Zhang, C.; Ren, T.; Zhao, X.; Su, Y.; Wang, Q.; Zhang, T.; He, B.; Wu, L.-Y.
10.1101/2024.04.01.587649 — immunology — Posted on 2024-04-02
4335 Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia
Martinez-Rivera, A.; Fetcho, R.; Birmingham, L.; Jiu, J. X.; Yang, R.; Foord, C.; Scala-Chavez, D.; Mekawy, N.; Pleil, K. E.; Pickel, V. M.; Liston, C.; Castorena, C. M.; Levitz, J.; Pan, Y.-X.; Briand, L. A.; Rajadhyaksha, A. M.; Lee, F. S.
10.1101/2024.04.02.585967 — neuroscience — Posted on 2024-04-02
4337 Mid-infrared photoacoustic brain imaging enabled by cascaded gas-filled hollow-core fiber lasers
Zhang, C.; Sui, K.; Meneghetti, M.; Antonio-Lopez, J. E.; Dasa, M. K.; Berg, R. W.; Amezcua-Correa, R.; Wang, Y.; Markos, C.
10.1101/2024.04.02.587715 — neuroscience — Posted on 2024-04-02
4342 Stored Elastic Bending Tension as a Mediator of Embryonic Body Folding
Zaher, M.; Yelin, R.; Arraf, A.; Jadon, J.; Asleh, M. A.; Goltzman, S.; Shaulov, L.; Reinhardt, D. P.; Schultheiss, T. M.
10.1101/2024.04.02.587781 — developmental biology — Posted on 2024-04-02
4343 Age-associated growth control modifies leaf proximodistal symmetry and enables leaf shape diversification
Li, X.-M.; Jenke, H.; Strauss, S.; Wang, Y.; Bhatia, N.; Kierzkowski, D.; Lymbouridou, R.; Huijser, P.; Smith, R. S.; Runions, A.; Tsiantis, M.
10.1101/2024.04.02.587754 — developmental biology — Posted on 2024-04-02
4347 APOE regulates the transport of GM1
Zhang, D. Y.; Wang, J.; Huang, G.; Langberg, S.; Ding, F.; Dokholyan, N. V.
10.1101/2024.04.02.587789 — neuroscience — Posted on 2024-04-02
4349 Comprehensive Landscape of Non-muscle Invasive Bladder Cancer Tumour Microenvironment and Prognostic value of Cancer-Associated Myofibroblasts
Canizo, C. M.; Guerrero-Ramos, F.; Perez-Escavy, M.; Lodewijk, I.; Suarez-Cabrera, C.; Morales, L.; Nunes, S. P.; Munera-Maravilla, E.; Rubio, C.; Sanchez, R.; Rodriguez-Izquierdo, M.; Martinez de Villarreal, J.; Real, F. X.; Castellano, D.; Martin-Arriscado, C.; Lora Pablos, D.; Rodriguez-Antolin, A.; Duenas, M.; Paramio, J. M.; Martinez, V. G.
10.1101/2023.10.26.564112 — cancer biology — Posted on 2024-04-02
4350 Ontology-based modeling, integration, and analysis of heterogeneous clinical, pathological, and molecular kidney data for precision medicine
He, Y.; Barisoni, L.; Rosenberg, A. Z.; Robinson, P.; Diehl, A. D.; Chen, Y.; Phuong, J. P.; Hansen, J.; Herr, B. W.; Borner, K.; Schaub, J.; Bonevich, N.; Arnous, G.; Boddapati, S.; Zheng, J.; Alakwaa, F.; Sarder, P.; Duncan, W. D.; Liang, C.; Valerius, M. T.; Jain, S.; Iyengar, R.; Himmelfarb, J.; Kretzler, M.; Kidney Precision Medicine Project,
10.1101/2024.04.01.587658 — bioinformatics — Posted on 2024-04-02
4353 Quantitating SARS-CoV-2 Neutralizing Antibodies from Human Dried Blood Spots
Berman, K.; Van Slyke, G.; Novak, H.; Rock, J.; Bievenue, R.; Damjanovic, A.; DeRosa, K.; Mirabile, G.; Giradin, R.; Dupuis, A.; McDonough, K.; Parker, M. M.; Styer, L.; MANTIS, N. J.
10.1101/2024.03.18.585599 — immunology — Posted on 2024-04-02
4357 Inferring gene regulatory networks by hypergraph variational autoencoder
su, g.; wang, h.; zhang, y.; Coster, A. C.; Wilkins, M.; Canete, P. F.; Yu, D.; Yang, Y.; zhang, w.
10.1101/2024.04.01.586509 — bioinformatics — Posted on 2024-04-02
4361 Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts
Luo, Y.; Cao, K.; Chiu, J.; Chen, H.; Wang, H.-J.; Thornton, M. E.; Grubbs, B. H.; Kolb, M.; Parmacek, M. S.; Mishina, Y.; Shi, W.
10.1101/2023.09.26.559527 — developmental biology — Posted on 2024-04-02
4362 Host factor PLAC8 is required for pancreas infection by SARS-CoV-2
Ibarguen Gonzalez, L.; Heller, S.; DeDiego, M. L.; Lopez-Garcia, D.; Gomez-Valero, A. M.; Barth, T. F.; Gallego, P.; Fernandez-Cardenas, I.; Alzate-Pinol, S.; Crespi, C.; Mena-Guerrero, J. A.; Cisneros-Barroso, M. E.; Ugalde, A. P.; Bretones, G.; Steenblock, C.; Kleger, A.; Barcelo, C.
10.1101/2023.08.18.553908 — cell biology — Posted on 2024-04-02
4363 A mechanism that transduces lysosomal damage signals to stress granule formation for cell survival
Duran, J.; Poolsup, S.; Allers, l.; Leums, M.; Cheng, Q.; Pu, J.; Salemi, M.; Phinney, B.; Jia, J.
10.1101/2024.03.29.587368 — cell biology — Posted on 2024-04-02
4365 USP7 Inhibition Promotes Age-related Osteoporosis and Osteoporotic Osseointegration via Efferocytosis and Senolysis
Zhou, F.; Wang, Z.; Li, H.; Wang, D.; Wu, Z.; Bai, F.; Wang, Q.; Luo, W.; Zhang, G.; Xiong, Y.; Wu, Y.
10.1101/2023.11.15.567232 — cell biology — Posted on 2024-04-02
4367 O Short-branch Microsporidia, Where Art Thou? Identifying diversity hotspots for future sampling
Gross, M.; Rajter, L.; Mahe, F.; Bass, D.; Berney, C.; Henry, N.; de Vargas, C.; Dunthorn, M. E.
10.1101/2024.04.01.587430 — microbiology — Posted on 2024-04-02
4368 Brain tumor induce immunoregulatory dendritic cells in tumor draining lymph nodes that can be targeted by OX40
Badillo-Godinez, O.; Helfridsson, L.; Niemi, J.; Karimi, S.; Ramachandran, M.; Hellstrom, M.
10.1101/2024.04.01.587531 — immunology — Posted on 2024-04-02
4369 Single-cell transcriptional landscape of temporal neutrophil response to burn wound in larval zebrafish
Hou, Y.; Khatri, P.; Rindy, J.; Schultz, Z.; Gao, A.; Chen, Z.; Gibson, A.; Huttenlocher, A.; Dinh, H. Q.
10.1101/2024.04.01.587641 — immunology — Posted on 2024-04-02
4370 Large-scale statistical mapping of T-cell receptor β sequences to Human Leukocyte Antigens
Zahid, H. J.; Taniguchi, R.; Ebert, P.; Chow, I.-T.; Gooley, C.; Lv, J.; Pisani, L.; Rusnak, M.; Elyanow, R.; Takamatsu, H.; Zhou, W.; Greissl, J.; Robins, H.; Carlson, J. M.
10.1101/2024.04.01.587617 — immunology — Posted on 2024-04-02
4371 The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian function in vivo
Ferro, A.; Arshad, A.; Boyd, L.; Stanley, T.; Berisha, A.; Vrudhula, U.; Gomez, A. M.; Borniger, J. C.; Cheadle, L. M.
10.1101/2024.04.02.587786 — neuroscience — Posted on 2024-04-02
4374 Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice
Holcomb, M.; Marshall, A.; Flinn, H.; Lozano, M.; Soriano, S.; Gomez-Pinilla, F.; Treangen, T.; Villapol, S.
10.1101/2024.04.01.587652 — neuroscience — Posted on 2024-04-02
4380 Anti-EGFR aptamer exhibits direct anti-cancer effects in NSCLC cells harboring EGFR L858R mutations
Thomas, B. J.; Awan, S. Z.; Joshi, T.; Daniels, M. A.; Porciani, D.; Burke-Aguero, D. H.
10.1101/2024.04.01.587576 — cancer biology — Posted on 2024-04-02
4388 A versatile information retrieval framework for evaluating profile strength and similarity
Kalinin, A. A.; Arevalo, J.; Vulliard, L.; Serrano, E.; Tsang, H.; Bornholdt, M.; Rajwa, B.; Carpenter, A. E.; Way, G. P.; Singh, S.
10.1101/2024.04.01.587631 — bioinformatics — Posted on 2024-04-02
4390 Extracellular vesicles-based point-of-care testing for the diagnosis and monitoring of Alzheimer's disease
Li, X.; Chen, J.; yang, y.; Cai, H.; Ao, Z.; Xing, Y.; Li, k.; Yang, K.; Wallace, A.; Friend, J.; Lee, L. P.; Wang, N.; Guo, F.
10.1101/2024.03.31.587511 — bioengineering — Posted on 2024-04-02
4391 SPLICER: A Highly Efficient Base Editing Toolbox That Enables In Vivo Therapeutic Exon Skipping
Miskalis, A.; Shirguppe, S.; Winter, J.; Elias, G.; Swami, D.; Nambiar, A.; Stilger, M.; Woods, W.; Gosstola, N.; Gapinske, M.; Zeballos, A.; Moore, H.; Maslov, S.; Gaj, T.; Perez-Pinera, P.
10.1101/2024.04.01.587650 — bioengineering — Posted on 2024-04-02
4393 Study Design and Interim Analysis of the Cancer Lifetime Assessment Screening Study in Canines (CLASSiC): The First Prospective Cancer Screening Study in Dogs Using Next-Generation Sequencing-Based Liquid Biopsy
Flory, A.; Gray, S.; McLennan, L. M.; Rafalko, J. M.; Marshall, M. A.; Wotrang, K.; Kroll, M.; Flesner, B. K.; O'Kell, A. L.; Cohen, T. A.; Ruiz-Perez, C. A.; Sandford, E.; Clavere-Graciette, A.; Phelps-Dunn, A.; Motalli-Pepio, R.; Nakashe, P.; Cristobal, M. A.; Anderson, P.; Hicks, S. C.; Tynan, J. A.; Kruglyak, K. M.; Tsui, D. W. Y.; Grosu, D. S.
10.1101/2024.04.01.587600 — genomics — Posted on 2024-04-02
4394 msCNVS: medium throughput single cell copy number variation sequencing with barcoded library construction free of preamplification toward clinical implementation
Lin, G.; Peng, B.; Chen, C.; Dong, Z.; Xu, M.; Gao, J.; Yu, J.; Jia, B.; Luo, C.; Hua, R.; Xiao, C.; Wang, L.; Mai, L.; Zhang, Y.; Lu, Y.; He, Y.; Song, Y.; Marjani, S. L.; Zhang, W.; Zhang, J.; Zhong, M.; Quan, S.; Weissman, S. M.; Zhu, H.; Pan, X.
10.1101/2024.04.01.587505 — genomics — Posted on 2024-04-02
4395 Genetic Diversity Analysis of a Multi-Gene Bank Collection of Eggplant (Solanum melongena L.): Insights from Morphological Traits and SSR Markers
Lipio, P. L. G.; Oloc-oloc, I. B. M.; Guinto, T. D.; Diamante, B. A. A.; Caraan, J. A. M.; Hermoso, R. T.; Huelgas, V. D.; Hautea, D. M.
10.1101/2024.04.01.587642 — genetics — Posted on 2024-04-02
4399 Ascorbate depletion increases quiescence and self-renewal potential in hematopoietic stem cells and multipotent progenitors
Comazzetto, S.; Cassidy, D.; DeVilbiss, A. W.; Jeffery, E. C.; Ottesen, B. R.; Reyes, A. R.; Muh, S.; Mathews, T. P.; Chen, B.; Zhao, Z. P.; Morrison, S. J.
10.1101/2024.04.01.587574 — cell biology — Posted on 2024-04-02
4401 MATRIN3 deficiency triggers autoinflammation via cGAS-STING activation
Islam, Z.; Polash, A.; Suzawa, M.; Chim, B.; Kuhn, S.; Sultana, S.; Cutrona, N.; Smith, P. T.; Kabat, J.; Ganesan, S.; Foroushani, A.; Hafner, M.; Muljo, S. A.
10.1101/2024.04.01.587645 — molecular biology — Posted on 2024-04-02
4403 Supplier-origin gut microbiomes affect host body weight and select autism-related behaviors
McAdams, Z. L.; Gustafson, K.; Russell, A. L.; Self, R.; Petry, A.; Lever, T.; Ericsson, A. C.
10.1101/2024.04.01.587648 — microbiology — Posted on 2024-04-02
4404 A specific and portable gene expression program underlies antigen archiving by lymphatic endothelial cells
Sheridan, R. M.; Doan, T. A.; Lucas, C. A.; Forward, T. S.; Uecker-Martin, A.; Morrison, T.; Hesselberth, J.; Tamburini, B. A. J.
10.1101/2024.04.01.587647 — immunology — Posted on 2024-04-02
4405 The Switchmaze: an open-design device for measuring motivation and drive switching in mice
Hartmann, C.; Mahajan, A.; Borges, V.; Razenberg, L.; Thoennes, Y.; Karnani, M. M.
10.1101/2024.01.31.578188 — neuroscience — Posted on 2024-04-02
4406 The Role of Inhibition in fMRI Resting-State Negative Correlations
Harita, S.; Momi, D.; Wang, Z.; Bastiaens, S. P.; Griffiths, J. D.
10.1101/2024.03.01.583030 — neuroscience — Posted on 2024-04-02
4411 mTORC1-dependent SOCE activity regulates synaptic gene expression and muscle response to denervation
Prola, A.; Dupont, O.; Rajendran, J.; Chabry, F.; Koenig, S.; Frieden, M.; Castets, P.
10.1101/2024.04.01.587665 — physiology — Posted on 2024-04-02
4412 Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells
Huang, Y.; Mo, H.; Yang, J.; Gao, L.; Tao, T.; Shu, Q.; Guo, W.; Zhao, Y.; Lyu, J.; Wang, Q.; Guo, J.; Zhai, H.; Zhu, L.; Chen, H.; Xu, G.
10.1101/2024.04.01.587569 — physiology — Posted on 2024-04-02
4417 PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis
Liu, G.; Hou, Y.; Jin, X.; Zhang, Y.; Sun, C.; Huang, C.; Ren, Y.; Gao, J.; Wang, X.; Jiang, X.
10.1101/2024.02.05.578960 — cell biology — Posted on 2024-04-02
4418 Translational regulation enhances distinction of cell types in the nervous system
Ichinose, T.; Kondo, S.; Kanno, M.; Shichino, Y.; Mito, M.; Iwasaki, S.; Tanimoto, H.
10.1101/2023.06.15.545207 — neuroscience — Posted on 2024-04-02
4419 In silico, in vitro, and in vivo models reveal EPHA2 as a target for decreasing inflammation and pathological endochondral ossification in osteoarthritis.
Ferrao Blanco, M. N.; Lesage, R.; Kops, N.; Fahy, N.; Bekedam, F. T.; Chavli, A.; Bastiaansen-Jenniskens, Y. M.; Geris, L.; Chambers, M. G.; Pitsillides, A. A.; Narcisi, R.; van Osch, G. J. V. M.
10.1101/2022.06.12.495737 — pharmacology and toxicology — Posted on 2024-04-02
4421 Sequence-based genome-wide association studies reveal the polygenic architecture of Varroa destructor resistance in Western honey bees Apis mellifera
Eynard, S. E.; Mondet, F.; Basso, B.; Bouchez, O. E.; Le Conte, Y.; Dainat, B.; Decourtye, A.; Genestout, L.; Guichard, M.; Guillaume, F.; Labarthe, E.; Locke, B.; Mahla, R.; de Miranda, J. R.; Neuditschko, M.; Phocas, F.; Tabet, K.; Vignal, A.; Servin, B.
10.1101/2024.02.16.580755 — genetics — Posted on 2024-04-02
4422 Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome
Kono, Y.; Pack, C.-G.; Ichikawa, T.; Komatsubara, A.; Adam, S. A.; Miyazawa, K.; Rolas, L.; Nourshargh, S.; Medalia, O.; Goldman, R. D.; Fukuma, T.; Kimura, H.; Shimi, T.
10.1101/2023.09.02.555826 — cell biology — Posted on 2024-04-02
4425 Semi-supervised Bayesian integration of multiple spatial proteomics datasets
Coleman, S. D.; Breckels, L.; Waller, R. F.; Lilley, K. S.; Wallace, C.; Kirk, P. D. W.; Crook, O. M.
10.1101/2024.02.08.579519 — systems biology — Posted on 2024-04-02
4426 Novel metagenomics analysis of stony coral tissue loss disease
Heinz, J. M.; Lu, J.; Huebner, L. K.; Salzberg, S. L.; Sommer, M.; Rosales, S. M.
10.1101/2024.01.02.573916 — bioinformatics — Posted on 2024-04-02
4429 Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage
Boerner, K.; Blood, P. D.; Silverstein, J. C.; Ruffalo, M.; Teichmann, S. A.; Pryhuber, G.; Misra, R. S.; Purkerson, J. M.; Fan, J.; Hickey, J. W.; Molla, G.; Xu, C.; Zhang, Y.; Weber, G. M.; Jain, Y.; Qaurooni, D.; Kong, Y.; Bueckle, A.; Herr, B. W.
10.1101/2024.03.27.587041 — bioinformatics — Posted on 2024-04-02
4430 Genome-wide association study of glucocerebrosidase activity modifiers.
Somerville, E. N.; Krohn, L.; Senkevich, K.; Yu, E.; Ahmad, J.; Asayesh, F.; Ruskey, J. A.; Spiegelman, D.; Fahn, S.; Waters, C.; Sardi, S. P.; Alcalay, R. N.; Gan-Or, Z.
10.1101/2024.03.27.586821 — genetics — Posted on 2024-04-02
4432 Flame-forged divergence? Ancient human fires and the evolution of diurnal and nocturnal lineages in Mediterranean geckos
Fulgione, D.; Russo, D.; Rivieccio, E.; Maselli, V.; Avallone, B.; Mondanaro, A.; Giurato, G.; Buglione, M.
10.1101/2024.03.05.583480 — evolutionary biology — Posted on 2024-04-02
4433 Partitioning changes in ecosystem productivity by effects of species interactions in biodiversity experiments
Tao, J.; Nock, C.; Searle, E. B.; Huang, s.; Man, R.; Yang, H.; Freschet, G.; Violle, C.; Zheng, J.
10.1101/2024.03.30.587418 — ecology — Posted on 2024-04-02
4434 A Hierarchical Model for eDNA Fate and Transport Dynamics Accommodating Low Concentration Samples
Augustine, B. C.; Hutchins, P. R.; Jones, D. N.; Williams, J. R.; Leinonen, E.; Sepulveda, A. J.
10.1101/2024.03.27.586987 — ecology — Posted on 2024-04-02
4436 SLIRP mediates nuclear-mitochondrial communication during antiviral signaling to promote robust interferon response
Ku, D.; Yang, Y.; Park, Y.; Jang, D.; Lee, K.; Lee, N.; Lee, Y.-k.; Lee, J.; Han, Y. B.; Jang, S.; Choi, S. R.; Ha, Y.-J.; Choi, Y. S.; Jeong, W.-J.; Lee, Y. J.; Lee, K. J.; Cha, S.; Kim, Y.
10.1101/2024.03.28.587146 — molecular biology — Posted on 2024-04-02
4440 Serial fermentation in milk generates functionally diverse community lineages with different degrees of structure stabilization
Gapp, C.; Dijamentiuk, A.; Mangavel, C.; Callon, C.; Theil, S.; Revol-Junelles, A.-M.; Chassard, C.; Borges, F.
10.1101/2024.04.01.587544 — microbiology — Posted on 2024-04-02
4442 T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes
Darguzyte, M.; Amtczak, P.; Bachurski, D.; Hoelker, P.; Abedpour, N.; Gholaminpoorfard, R.; Schlösser, H.; Wennhold, K.; Thelen, M.; Garcia-Marquez, M.; Koenig, J.; Schneider, A.; Braun, T.; Klawonn, F.; Damrat, M.; Rahman, M.; Kleid, J.-M.; Theobald, S.; Bauer, E.; von Kaisenberg, C.; Talbot, S. R.; Schultz, L.; Soper, B.; Stripecke, R.
10.1101/2024.03.26.586814 — immunology — Posted on 2024-04-02
4444 Agency accounts for the effect of feedback transparency on motor imagery neurofeedback performance
Dussard, C.; Pillette, L.; Dumas, C.; Pierrieau, E.; Hugueville, L.; Lau, B.; Jeunet, C.; George, N.
10.1101/2024.02.27.582270 — neuroscience — Posted on 2024-04-02
4445 Cortical networks relating to arousal are differentially coupled to neural activity and hemodynamics
Meyer-Baese, L.; Morrissette, A. E.; Wang, Y.; Le Chatelier, B.; Borden, P. Y.; Keilholz, S.; Stanley, G. B.; Jaeger, D.
10.1101/2022.12.01.518759 — neuroscience — Posted on 2024-04-02
4446 Random adversarial threshold search enables automated DNA screening
Gretton, D.; Wang, B.; Edison, R.; Foner, L.; Berlips, J.; Vogel, T.; Kysel, M.; Chen, W.; Sage-Ling, F.; Van Hauwe, L.; Wooster, S.; Weinstein-Raun, B.; DeBenedictis, E. A.; Liu, A. B.; Chory, E.; Cui, H.; Li, X.; Dong, J.; Fabrega, A.; Dennison, C.; Don, O.; Ye, C.; Uberoy, K.; Rivest, R. L.; Gao, M.; Yu, Y.; Baum, C.; Damgard, I.; Yao, A. C.; Esvelt, K. M.
10.1101/2024.03.20.585782 — synthetic biology — Posted on 2024-04-02
4447 BZR1 promotes pluripotency acquisition and callus development through direct regulation of ARF7 and ARF19
Ebstrup, E. N.; Ammitsoe, T. J.; Blanco-Tourinan, N.; Hansen, J.; Hardtke, C. S.; Rodriguez, E.; Petersen, M.
10.1101/2024.03.22.586258 — plant biology — Posted on 2024-04-02
4448 Water deficit response in nodulated soybean roots: a comprehensive transcriptome and translatome network analysis
Sainz, M. M.; Filippi, C. V.; Eastman, G.; Sotelo-Silveira, M.; Zardo, S.; Martinez-More, M.; Sotelo-Silveira, J.; Borsani, O.
10.1101/2024.03.29.587361 — plant biology — Posted on 2024-04-02
4449 Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer
DeAngelo, S. L.; Dziechciarz, S.; Solanki, S.; Shin, M.; Zhao, L.; Balia, A.; El-Derany, M. O.; Das, N. K.; Castillo, C.; Bell, H. N.; Paulo, J. A.; Zhang, Y.; Rossiter, N. J.; McCulla, E. C.; He, J.; Talukder, I.; Schafer, Z. T.; Neamati, N.; Mancias, J. D.; Koutmos, M.; Shah, Y. M.
10.1101/2024.03.29.587381 — cancer biology — Posted on 2024-04-02
4450 Flow Physics Explains Morphological Diversity of Ciliated Organs
Ling, F.; Essock-Burns, T.; McFall-Ngai, M.; Katija, K.; Nawroth, J. C.; Kanso, E.
10.1101/2023.02.12.528181 — biophysics — Posted on 2024-04-02
4453 An in vivo platform to identify pathogenic loci
Yamada, S.; Ou, T. N.; Nachadalingam, S.; Yang, S.; Johnson, A. N.
10.1101/2023.11.01.565153 — physiology — Posted on 2024-04-02
4454 Patterns of siderophore production and utilization at Station ALOHA from the surface to mesopelagic waters
Bundy, R. M.; Manck, L. E.; Repeta, D. J.; Church, M. J.; Hawco, N. J.; Boiteau, R. M.; Park, J.; Delong, E. F.; Saito, M.
10.1101/2022.10.04.510528 — bioinformatics — Posted on 2024-04-02
4457 Morphological and functional convergence of visual projections neurons from diverse neurogenic origins in Drosophila
El-Danaf, R. N.; Kapuralin, K.; Rajesh, R.; Simon, F.; Drou, N.; Pinto-Teixeira, F.; Ozel, M. N.; Desplan, C.
10.1101/2024.04.01.587522 — neuroscience — Posted on 2024-04-02
4459 Cardiovascular and vasomotor pulsations in the brain and periphery during awake and NREM sleep in a multimodal fMRI study
Tuunanen, J.; Helakari, H.; Huotari, N.; Vayrynen, T.; Jarvela, M.; Kananen, J.; Kivipaa, A.; Raitamaa, L.; Ebrahimi, S.-M.; Kallio, M.; Piispala, J.; Kiviniemi, V.; Korhonen, V.
10.1101/2024.04.02.587690 — neuroscience — Posted on 2024-04-02
4464 Group Heteroscedasticity - A Silent Saboteur of Power and False Discovery in RNA-Seq Differential Expression
Chatterjee, S.; Fadikar, A.; Hanumesh, V.; Meshram, S. S.; Zoh, R. S.; Ma, S.; Arunkumar, G.; Mallick, H.
10.1101/2024.04.01.587633 — bioinformatics — Posted on 2024-04-02
4468 Transcriptomic, clonal, and functional analyses reveal Liver tissue-imprinted immuno-profile of circulating autoreactive CD4 T cells in autoimmune liver diseases
Cardon, A.; Guinebretiere, T.; Dong, C.; Gil, L.; Ado, S.; Gavlovsky, P.-j.; Braud, M.; Danger, R.; Schultheiss, C.; Domene, A.; Paul-Guilloteaux, P.; Chevalier, C.; Bernier, L.; Judor, J.-P.; Fourgeux, C.; Imbert, A.; Khaldi, M.; Bardou-Jacquet, E.; Elkrief, L.; Lannes, A.; Silvain, C.; Schnee, M.; Tanne, F.; Vavasseur, F.; Brusselle, L.; Brouard, S.; Kwok, W.; Mosnier, J.-F.; Lohse, A. W.; Poschmann, J.; Binder, M.; Gournay, J.; Conchon, S.; Milpied, P.; Renand, A.
10.1101/2024.03.26.586770 — immunology — Posted on 2024-04-02
4469 Age-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG
Ding, X.; Wu, Y.; Rodriguez, V.; Ricco, E.; Okoh, J.; Liu, Y.; Kraushaar, D.; Rasband, M. N.
10.1101/2024.04.01.587609 — neuroscience — Posted on 2024-04-02
4470 Chilean brush tailed mouse (Octodon degus): a diurnal precocial rodent as a new model to study visual receptive field properties of superior colliculus neurons
Marquez, N. I.; Fernandez-Aburto, P. F.; Deichler, A.; Perales, I.; Letelier, J.-C.; Marin, G. J.; Mpodozis, J.; Pallas, S. L.
10.1101/2024.03.25.586655 — neuroscience — Posted on 2024-04-02
4471 RosetteArray Platform for Quantitative High-Throughput Screening of Human Neurodevelopmental Risk
Lundin, B. F.; Knight, G. T.; Fedorchak, N. J.; Krucki, K.; Iyer, N.; Maher, J. E.; Izban, N. R.; Roberts, A.; Cicero, M. R.; Robinson, J. F.; Iskandar, B. J.; Willett, R.; Ashton, R. S.
10.1101/2024.04.01.587605 — neuroscience — Posted on 2024-04-02
4474 The Role of Cilia in the Development, Survival, and Regeneration of Hair Cells
Boldizar, H.; Friedman, A.; Stanley, T.; Padilla, M.; Galdieri, J.; Sclar, A.; Stawicki, T. M.
10.1101/2024.04.01.587636 — neuroscience — Posted on 2024-04-02
4475 Computational Mechanisms of Neuroimaging Biomarkers Uncovered by Multicenter Resting-State fMRI Connectivity Variation Profile
Yamashita, O.; Yamashita, A.; Takahara, Y.; Sakai, Y.; Okamoto, Y.; Okada, G.; Takamura, M.; Nakamura, M.; Itahashi, T.; Hanakawa, T.; Togo, H.; Yoshihara, Y.; Murai, T.; Okada, T.; Narumoto, J.; Takahashi, H.; Takagishi, H.; Hosomi, K.; Kasai, K.; Okada, N.; Abe, O.; Imamizu, H.; Hayashi, T.; Koike, S.; Tanaka, S. C.; Kawato, M.; Brain/MINDS Beyond Human Brain MRI Group,
10.1101/2024.04.01.587535 — neuroscience — Posted on 2024-04-02
4476 Dissecting Reactive Astrocyte Responses: Lineage Tracing and Morphology-based Clustering
Delgado-Garcia, L. M.; OJALVO-SANZ, A. C.; Nakamura, T. K. E.; Martin-Lopez, E.; Porcionatto, M.; Lopez-Mascaraque, L.
10.1101/2024.04.01.587565 — neuroscience — Posted on 2024-04-02
4477 A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes
Sharma, S.; Cheema, M.; Tennant, K.; Boghozian, R.; Cota, A. P.; Brosschot, T. P.; Fitzpatrick, R. D.; Korbelin, J.; Reynolds, L.; Brown, C. E.
10.1101/2024.04.01.587630 — neuroscience — Posted on 2024-04-02
4482 Reliable cross-ion mode chemical similarity prediction between MS2 spectra
de Jonge, N. F.; Joas, D.; Truong, L.-J.; van der Hooft, J. J. J.; Huber, F.
10.1101/2024.03.25.586580 — bioinformatics — Posted on 2024-04-02
4483 Canary in the cardiac-valve coal mine: Flow velocity and inferred shear during prosthetic valve closure -predictors of blood damage and clotting
Scotten, L. N.; Siegel, R.; Blundon, D. J.; Deutsch, M.-A.; Martin, T. R. P.; Dutton, J. W.; Kolahdouz, E. M.; Griffith, B. E.
10.1101/2022.06.23.497372 — bioengineering — Posted on 2024-04-02
4484 Mag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome
Wu, C. C.; Tsantilas, K. A.; Park, J.; Plubell, D. L.; Sanders, J. A.; Naicker, P.; Govender, I.; Buthelezi, S.; Stoychev, S.; Jordaan, J.; Merrihew, G. E.; Huang, E.; Parker, E. D.; Riffle, M.; Hoofnagle, A. N.; Noble, W. S.; Poston, K. L.; Montine, T. J.; MacCoss, M. J.
10.1101/2023.06.10.544439 — biochemistry — Posted on 2024-04-02
4485 Co-transcriptional splicing facilitates transcription of gigantic genes
Yamashita, Y. M.; Fingerhut, J. M.; Lannes, R.; Whitfield, T. W.; Thiru, P.
10.1101/2024.04.02.587678 — developmental biology — Posted on 2024-04-02
4486 Combinatorial expression of neurexin genes regulates glomerular targeting by olfactory sensory neurons
Park, S. J.; Wang, I.-H.; Lee, N.; Jiang, H.-C.; Uemura, T.; Futai, K.; Kim, D.; Macosko, E.; Greer, P.
10.1101/2024.04.01.587570 — developmental biology — Posted on 2024-04-02
4491 Regulatory Functional Landscape of the HMX1 Gene for Normal Ear Development
Xu, X.; Chen, Q.; Huang, Q.; Cox, T. C.; Zhu, H.; Hu, J.; Han, X.; Meng, Z.; Wang, B.; Liao, Z.; Xu, W.; Xiao, B.; Lang, R.; Liu, J.; Li, Q.; Zhang, Q.; Antonarakis, S. E.; Zhang, J.; Fan, X.; Liu, H.; Zhang, Y.-B.
10.1101/2024.04.01.587639 — developmental biology — Posted on 2024-04-02
4494 Unilateral auditory deprivation reveals brainstem origin of a sensitive period for spatial hearing
Anbuhl, K. L.; Ferber, A. T.; Brown, A. D.; Benichoux, V.; Greene, N. T.; Tollin, D. J.
10.1101/2024.04.01.587638 — neuroscience — Posted on 2024-04-02
4495 Developmental convergence and divergence in human stem cell models of autism spectrum disorder
Gordon, A.; Yoon, S.-J.; Bicks, L. K.; Martin, J. M.; Pintacuda, G.; Arteaga, S. A.; Wamsley, B. A.; Guo, Q.; Elahi, L.; Dolmetsch, R. E.; Bernstein, J. A.; O'Hara, R.; Hallmayer, J. F.; Lage, K.; Pasca, S. P.; Geschwind, D.
10.1101/2024.04.01.587492 — neuroscience — Posted on 2024-04-02
4496 Level Dependent Subcortical EEG Responses to Continuous Speech
Kulasingham, J. P.; Innes-Brown, H.; Enqvist, M.; Alickovic, E. P.
10.1101/2024.04.01.587607 — neuroscience — Posted on 2024-04-02
4502 Invariant set theory for predicting failure of antibiotic cycling
Anderson, A.; Kinahan, M. W.; Gonzalez, A. H.; Udekwu, K.; Hernandez-Vargas, E. A.
10.1101/2024.02.06.579227 — bioinformatics — Posted on 2024-04-01
4503 Pseudo-grading of tumor subpopulations from single-cell transcriptomic data using Phenotype Algebra
Bhattacharya, N.; Rockstroh, A.; Deshpande, S. S.; Thomas, S. K.; Yadav, A.; Goswami, C.; Chawla, S.; Solomon, P.; Fourgeux, C.; Ahuja, G.; Hollier, B.; Kumar, H.; Roquilly, A.; Poschmann, J.; Lehman, M.; Nelson, C. C.; Sengupta, D.
10.1101/2022.12.28.522060 — bioinformatics — Posted on 2024-04-01
4504 HaploSight: An alternative approach for Y chromosomal haplogroup identification
Laoprapaipan, L.; Phusawang, K.; Laorchairangsi, P.; Kitnitchee, A.; Wachirawanitchkit, H.; Suwanparsert, B.; Promnun, P.
10.1101/2024.03.13.584919 — bioinformatics — Posted on 2024-04-01
4505 Patch-walking: Coordinated multi-pipette patch clamp for efficiently finding synaptic connections
Yip, M. C.; Gonzalez, M. M.; Lewallen, C. F.; Landry, C. R.; Kolb, I.; Yang, B.; Stoy, W. M.; Fong, M.-f.; Rowan, M. J.; Boyden, E. S.; Forest, C. R.
10.1101/2024.03.30.587445 — bioengineering — Posted on 2024-04-01
4507 Broadly neutralizing antibodies against emerging delta-coronaviruses
Rexhepaj, M.; Park, Y.-J.; Perruzza, L.; Asarnow, D.; McCallum, M.; Culap, K.; Saliba, C.; Leoni, G.; Balmeli, A.; Yoshiyama, C.; Dickinson, M. S.; Quispe, J.; Brown, J. T.; Tortorici, M. A.; Sprouse, K. R.; Taylor, A. L.; Starr, T. N.; Corti, D.; Begnini, F.; Veesler, D.
10.1101/2024.03.27.586411 — biochemistry — Posted on 2024-04-01
4508 A high-resolution haplotype pangenome uncovers somatic hybridization, recombination and intercontinental migration in oat crown rust
Henningsen, E.; Lewis, D.; Nazareno, E.; Huang, Y.-F.; Steffenson, B. J.; Boesen, B.; Kianian, S. F.; Stone, E.; Dodds, P.; Sperschneider, J.; Figueroa, M.
10.1101/2024.03.27.583983 — genomics — Posted on 2024-04-01
4510 Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1
Johnson, D.; Colijn, S.; Richee, J.; Yano, J.; Burns, M.; Davis, A. E.; Pham, V. N.; Saric, A.; Jain, A.; Yin, Y.; Castranova, D.; Melani, M.; Fujita, M.; Grainger, S.; Bonifacino, J. S.; Weinstein, B. M.; Stratman, A. N.
10.1101/2024.04.01.587559 — cell biology — Posted on 2024-04-01
4511 Spatiotemporal Clusters of ERK Activity Coordinate Cytokine-induced Inflammatory Responses in Human Airway Epithelial Cells
DeCuzzi, N. L.; Oberbauer, D.; Chmiel, K. J.; Pargett, M.; Ferguson, J. M. A.; Murphy, D.; Zeki, A. A.; Albeck, J. G.
10.1101/2024.02.03.578773 — cell biology — Posted on 2024-04-01
4512 Structural Basis of Non-Latent Signaling by the Anti-Mullerian Hormone Procomplex
Howard, J. A.; Hok, L.; Cate, R. L.; Sanford, N. J.; Hart, K. N.; Leach, E. A.; Bruening, A. S.; Pepin, D.; Donahoe, P. K.; Thompson, T. B.
10.1101/2024.04.01.587627 — molecular biology — Posted on 2024-04-01
4513 Nanoscale cellular organization of viral RNA and proteins in SARS-CoV-2 replication organelles
Andronov, L.; Han, M.; Zhu, Y.; Balaji, A.; Roy, A. R.; Barentine, A. E. S.; Patel, P.; Garhyan, J.; Qi, L. S.; Moerner, W. E.
10.1101/2023.11.07.566110 — microbiology — Posted on 2024-04-01
4514 Oscillatory traveling waves reveal predictive coding abnormalities in schizophrenia
Alamia, A.; Gordillo, D.; Chkonia, E.; Roinishvili, M.; Cappe, C.; Herzog, M. H.
10.1101/2023.10.09.561490 — neuroscience — Posted on 2024-04-01
4516 Photoemission electron microscopy for connectomics
Boergens, K. M.; Wildenberg, G.; Li, R.; Lambert, L.; Moradi, A.; Stam, G.; Tromp, R.; van der Molen, S. J.; King, S. B.; Kasthuri, N.
10.1101/2023.09.05.556423 — neuroscience — Posted on 2024-04-01
4521 SLC25A46 is in contact with lysosomes and plays a role in mitochondrial cholesterol homeostasis
Schuettpelz, J.; Watt, K.; Antonicka, H.; janer, a.; Larsson, O.; Shoubridge, E. A.
10.1101/2024.04.01.587618 — cell biology — Posted on 2024-04-01
4522 Enhancing metabarcoding efficiency and ecological insights through integrated taxonomy and DNA reference barcoding: a case study on beach meiofauna
Macher, J.-N.; Martinez, A.; Cakir, S.; Cholley, P.-E.; Christoforou, E.; Curini Galletti, M.; van Galen, L.; Garcia-Cobo, M.; Jondelius, U.; de Jong, D.; Leasi, F.; Lemke, M.; Rubio Lopez, I.; Sanchez, N.; Sorensen, M. V.; Todaro, M. A.; Renema, W.; Fontaneto, D.
10.1101/2024.04.01.587521 — molecular biology — Posted on 2024-04-01
4525 High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells
Cochrane, R. W.; Robino, R. A.; Granger, B.; Allen, E.; Vaena, S.; Romeo, M. J.; de Cubas, A. A.; Berto, S.; Ferreira, L. M. R.
10.1101/2024.03.31.587467 — immunology — Posted on 2024-04-01
4527 Landscape profiling of PET depolymerases using a natural sequence cluster framework
Seo, H.; Hong, H.; Park, J.; Lee, S. H.; Ki, D.; Ryu, A.; Sagong, H.-Y.; Kim, K.-J.
10.1101/2024.04.01.587509 — systems biology — Posted on 2024-04-01
4529 Discovering cancer stem-like cells using Spatial transcriptomic analysis: Nuclear factor I X as a novel therapeutic target for gastric cancer
Ishikawa, A.; Fukui, T.; Kido, A.; Katsuya, N.; Kuraoka, K.; Uraoka, N.; Suzuki, T.; Oka, S.; Kotachi, T.; Ashktorab, H.; Smoot, D.; Yasui, W.
10.1101/2024.03.31.587468 — pathology — Posted on 2024-04-01
4530 ComPRePS: An Automated Cloud-based Image Analysis tool to democratize AI in Digital Pathology
Mimar, S.; Paul, A. S.; Lucarelli, N.; Boarder, S.; Santo, B. A.; Naglah, A.; Barisoni, L.; Hodgin, J.; Rosenberg, A.; Clapp, W.; Sarder, P.; for the Kidney Precision Medicine Project,
10.1101/2024.03.21.586102 — pathology — Posted on 2024-04-01
4531 IL-7 mediated upregulation of VLA-4 increases accumulation of adoptively transferred T lymphocytes in murine glioma.
Singh, K.; Hotchkiss, K. M.; Cook, S. L.; Noldner, P.; Zhou, Y.; Moelker, E. M.; Railton, C. O.; Blandford, E. E.; Puviindran, B. J.; Wallace, S. E.; Norberg, P. K.; Archer, G. E.; Shaz, B.; Sampson, J. H.; Khasraw, M.; Fecci, P. E.
10.1101/2024.04.01.587634 — cancer biology — Posted on 2024-04-01
4535 High resolution cryo-EM of V-ATPase in native synaptic vesicles
Coupland, C. E.; Karimi, R.; Bueler, S. A.; Liang, Y.; Courbon, G. M.; Di Trani, J. M.; Wong, C. J.; Saghian, R.; Youn, J.-Y.; Wang, L.-Y.; Rubinstein, J. L.
10.1101/2024.04.01.587493 — biochemistry — Posted on 2024-04-01
4536 Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses
Matsui, A.; Spangler, C.; Elferich, J.; Shiozaki, M.; Jean, N.; Zhao, X.; Qin, M.; Zhong, H.; Yu, Z.; Gouaux, E.
10.1101/2024.04.01.587595 — biochemistry — Posted on 2024-04-01
4538 Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan
Scherer, M.; Singh, I.; Braun, M.; Szu-Tu, C.; Kardorff, M.; Ruehle, J.; Froemel, R.; Beneyto-Calabuig, S.; Raffel, S.; Rodriguez-Fraticelli, A.; Velten, L.
10.1101/2024.04.01.587514 — genomics — Posted on 2024-04-01
4539 TDG orchestrates ATF4-dependent gene transcription during retinoic acid-induced cell fate acquisition
Turpin, M.; Madigou, T.; Bizot, M.; Acker, R.; Watrin, E.; Benoit, G.; Sawvell, K.; Avner, S.; Palierne, G.; Fourgeux, C.; Braud, M.; Poschmann, J.; Le Peron, C.; Salbert, G.
10.1101/2024.04.01.587571 — genomics — Posted on 2024-04-01
4540 HHIP protein interactions in lung cells provide insight into COPD pathogenesis
Deritei, D.; Inuzuka, H.; Castaldi, P. J.; Yun, J. H.; Xu, Z.; Anamika, W. J.; Asara, J. M.; Guo, F.; Zhou, X.; Glass, K.; Wei, W.; Silverman, E. K.
10.1101/2024.04.01.586839 — genetics — Posted on 2024-04-01
4541 Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes
Almeida, M. V.; Blumer, M.; Yuan, C. U.; Sierra, P.; Price, J.; Quah, F. X.; Friman, A.; Dallaire, A.; Vernaz, G.; Putman, A.; Smith, A.; Joyce, D.; Butter, F.; Haase, A.; Durbin, R.; Santos, M. E.; Miska, E.
10.1101/2024.04.01.587621 — evolutionary biology — Posted on 2024-04-01
4543 Long-read sequencing to detect full-length protein-protein interactions
Ramadan, S.; Guan, Y.; Ahmed, A. A.; Aleksic, J.; Elmagarmid, K. A.; Syed, L. F.; Mohamoud, Y. A.; Malek, J. A.
10.1101/2024.04.01.586447 — molecular biology — Posted on 2024-04-01
4544 IS-PRM-based peptide targeting informed by long-read sequencing for alternative proteome detection
Korchak, J. A.; Jeffery, E. D.; Bandyopadhyay, S.; Jordan, B. T.; Lehe, M.; Watts, E. F.; Fenix, A.; Wilhelm, M.; Sheynkman, G. M.
10.1101/2024.04.01.587549 — molecular biology — Posted on 2024-04-01
4545 A conserved function of corepressors is to nucleate assembly of the transcriptional preinitiation complex.
Leydon, A. R.; Downing, B.; Sanchez, J. S.; Loll-Krippleber, R.; Belliveau, N. M.; Rodriguez-Mias, R. A.; Bauer, A. J.; Watson, I. J.; Bae, L.; Villen, J.; Brown, G. W.; Nemhauser, J. L.
10.1101/2024.04.01.587599 — molecular biology — Posted on 2024-04-01
4546 Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases
Han, L.; Pendleton, A.; Singh, A.; Xu, R.; Scott, S. A.; Palma, J. A.; Diebold, P.; Malarney, K. P.; Brito, I. L.; Chang, P. V.
10.1101/2024.04.01.587558 — microbiology — Posted on 2024-04-01
4548 Pseudocobalamin production and use in Synechococcus cultures and communities
Bannon, C. C.; Soto, M. A.; Rowland, E.; Chen, N.; Gleason, A.; Devred, E.; LaRoche, J.; Bertrand, E. M.
10.1101/2024.04.01.587587 — microbiology — Posted on 2024-04-01
4549 The Tradeoffs Between Persistence and Mutation Rates at Sub-Inhibitory Antibiotic Concentrations in Staphylococcus aureus
Ismail, A. S.; Berryhill, B. A.; Gil-Gil, T.; Manuel, J. A.; Smith, A. P.; Baquero, F.; Levin, B. R.
10.1101/2024.04.01.587561 — microbiology — Posted on 2024-04-01
4550 TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming
Zhu, W.; Xu, X.; Nagarajan, V.; Guo, J.; Pent, Z.; Zhang, A.; Liu, J.; Mattapallil, M. J.; Jittayasothorn, E.; Horai, R.; St. Leger, A. J.; Caspi, R.
10.1101/2024.04.01.587519 — immunology — Posted on 2024-04-01
4553 Identification of cell-type-specific response to silicon treatment in soybean leaves through single nucleus RNA-sequencing
Devkar, V.; Dagostino, L.; Kshetry, A. O.; Yong, L.; Nadaf, A. B.; Thirumlaikumar, V. P.; Skirycz, A.; Ma, J.; Stupar, R.; Herrera Estrella, L.; Deshmukh, R.; Patil, G. B.
10.1101/2024.04.01.587592 — plant biology — Posted on 2024-04-01
4554 Evaluating the Sex Dependent Influence of Sarcospan on Cardiometabolic Disease Traits in Mice
Rahimi Kahmini, A.; Valera, I. C.; Samarah, L.; Crawford, R. Q.; Elsheikh, S.; Kanashiro Takeuchi, R. M.; Olateju, B. S.; Matthews, A. R.; Mohammadipour, N.; Parvatiyar, M. S.
10.1101/2024.03.31.586423 — physiology — Posted on 2024-04-01
4557 NMR study of the interaction between MinC and FtsZ and modeling of the FtsZ:MinC complex.
Machado, L. E. S. F.; Castellen, P.; Blasios, V.; Ribeiro, H. V.; Bisson, A.; Benites-Pariente, J. S.; Nogueira, M. L. C.; Sforca, M.; Honorato, R. V.; de Oliveira, P. S. L.; Salinas, R. K.; Zeri, A. C. d. M.; Gueiros-Filho, F. J.
10.1101/2024.03.31.587266 — biophysics — Posted on 2024-04-01
4558 Inferring extrinsic factor-dependent single-cell transcriptome dynamics using a deep generative model
Kojima, Y.; Arioka, Y.; Hirose, H.; Hayashi, S.; Mizuhno, Y.; Nagaharu, K.; Okumura, H.; Ohishi, K.; Ishikawa, M.; Suzuki, Y.; Ozaki, N.; Shimamura, T.
10.1101/2024.04.01.587302 — bioinformatics — Posted on 2024-04-01
4559 Decoding Missense Variants by Incorporating Phase Separation via Machine Learning
Feng, M.; Wei, X.; Zheng, X.; Liu, L.; Lin, L.; Xia, M.; He, G.; Shi, Y.; Lu, Q.
10.1101/2024.04.01.587546 — bioinformatics — Posted on 2024-04-01
4561 GENOME-WIDE IDENTIFICATION, CHARACTERIZATION AND EXPRESSION ANALYSIS OF NA+/H+ EXCHANGER GENE FAMILY IN TWO CORCHORUS SPECIES
Ahmed, B.; Tabassum, A.; Hasan, F.; Aktar, N.; Hossain, S.; Mamun, A.-A.; Roni, M.; Bashar, K. K.; Alam, M.
10.1101/2024.04.01.587583 — bioinformatics — Posted on 2024-04-01
4563 High-throughput screening of human genetic variants by pooled prime editing
Herger, M.; Kajba, C. M.; Buckley, M.; Cunha, A.; Strom, M.; Findlay, G. M.
10.1101/2024.04.01.587366 — genomics — Posted on 2024-04-01
4564 Multiplex, multimodal mapping of variant effects in secreted proteins
Popp, N. A.; Powell, R. L.; Wheelock, M. K.; Zapp, B. D.; Holmes, K. J.; Sheldon, K. M.; Fletcher, S. N.; Wu, X.; Fayer, S.; Rubin, A. F.; Lannert, K. W.; Chang, A. T.; Sheehan, J. P.; Johnsen, J. M.; Fowler, D. M.
10.1101/2024.04.01.587474 — genomics — Posted on 2024-04-01
4566 A sneak peek at the high altitude adaptation of the Ladakh populations
Chorol, U.; Choudhury, B.; Norboo, T.; Wangchuk, N. P.; Chaubey, G.; Basu, C.
10.1101/2024.03.31.587460 — evolutionary biology — Posted on 2024-04-01
4573 Synthetic coevolution reveals adaptive mutational trajectories of neutralizing antibodies and SARS-CoV-2
Ehling, R. A.; Minot, M.; Overath, M. D.; Sheward, D. J.; Han, J.; Gao, B.; Taft, J. M.; Pertseva, M.; Weber, C. R.; Frei, L.; Bikias, T.; Murrell, B.; Reddy, S. T.
10.1101/2024.03.28.587189 — synthetic biology — Posted on 2024-04-01
4577 gRNAde: Geometric Deep Learning for 3D RNA inverse design
Joshi, C. K.; Jamasb, A. R.; Vinas, R.; Harris, C.; Mathis, S. V.; Morehead, A.; Lio, P.
10.1101/2024.03.31.587283 — bioinformatics — Posted on 2024-04-01
4578 Patch-walking: Coordinated multi-pipette patch clamp for efficiently finding synaptic connections
Yip, M. C.; Gonzalez, M. M.; Lewallen, C. F.; Landry, C. R.; Kolb, I.; Yang, B.; Stoy, W. M.; Fong, M.-f.; J Rowan, M.; Boyden, E. S.; Forest, C. R.
10.1101/2024.03.30.587445 — bioengineering — Posted on 2024-04-01
4580 Seq-Scope Protocol: Repurposing Illumina Sequencing Flow Cells for High-Resolution Spatial Transcriptomics
Kim, Y.; Cheng, W.; Cho, C.-S.; Hwang, Y.; Si, Y.; Park, A.; Schrank, M.; Hsu, J.-E.; Xi, J.; Kim, M.; Pedersen, E.; Koues, O. I.; Wilson, T.; Jun, G.; Kang, H. M.; Lee, J. H.
10.1101/2024.03.29.587285 — genomics — Posted on 2024-04-01
4581 A major effect locus involved in migration timing is shared by pink and sockeye salmon
Barry, P. D.; Tallmon, D. A.; Howe, N.; Baetscher, D.; D'Amelio, K.; Vulstek, S.; Russell, J.; Gharrett, A. J.; Larson, W.
10.1101/2024.03.30.587279 — genomics — Posted on 2024-04-01
4582 A paired analysis of mercury among non-invasive tissues to inform bat conservation monitoring
Simonis, M. C.; Whitmore, K.; Dyer, K. E.; Allira, M.; Demory, B.; Chumchal, M. M.; Becker, D.
10.1101/2024.03.31.587502 — ecology — Posted on 2024-04-01
4583 Assessing a Role for Sarcospan in Immune Function
Valera, I. C.; Rahimi Kahmini, A.; Smith, K. A.; Crawford, R. Q.; Parvatiyar, M. S.
10.1101/2024.03.31.587501 — immunology — Posted on 2024-04-01
4584 Targeting the expansion of myeloid-derived suppressor cells in liver cirrhosis
Flint, E. E.; Ercan, C.; Mitchell, E.; Pop, O. T.; Geng, A.; Jorzik, P.; Possamai, L. A.; Brenig, R. G.; Morel, S.; Sieber, P.; Singanayagam, A.; Matter, M. S.; Semela, D.; Heim, M. H. E.; Demougin, P.; Roux, J.; Terracciano, L. M.; Triantafyllou, E.; Bernsmeier, C.
10.1101/2024.03.29.587228 — immunology — Posted on 2024-04-01
4588 Sex-Specific Cardiovascular Adaptations to Simulated Microgravity in Sprague-Dawley Rats
Elsangeedy, E.; Yamaleyeva, D. N.; Edenhoffer, N. P.; Deak, A.; Soloshenko, A.; Ray, J.; Sun, X.; Shaltout, O. H.; Cruz Diaz, N.; Westwood, B.; Kim-Shapiro, D.; Diz, D. I.; Soker, S.; Pulgar, V. M.; Ronca, A.; Willey, J. S.; Yamaleyeva, L. M.
10.1101/2024.03.29.587264 — physiology — Posted on 2024-04-01
4590 Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling
DeVito, N. C.; Nguyen, Y.-V.; Sturdivant, M.; Plebanek, M. P.; Howell, K.; Yarla, N.; Jain, V.; Aksu, M.; Beasley, G.; Theivanthiran, B.; Hanks, B. A.
10.1101/2024.03.31.587500 — cancer biology — Posted on 2024-04-01
4594 DeepSS2GO: protein function prediction from secondary structure
Song, F. V.; Su, J.; Huang, S.; Zhang, N.; Li, K.; Ni, M.; Liao, M.
10.1101/2024.03.30.584129 — bioinformatics — Posted on 2024-04-01
4596 Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic Screening
Hurt, R. C.; Jin, Z.; Soufi, M.; Wong, K. K.; Sawyer, D. P.; Shen, H. K.; Dutka, P.; Deshpande, R.; Zhang, R.; Mittelstein, D. R.; Shapiro, M. G.
10.1101/2024.03.30.587094 — bioengineering — Posted on 2024-04-01
4600 Machine learning predictions improve identification of real-world cancer driver mutations
Tran, T. N.; Fong, C.; Pichotta, K.; Luthra, A.; Shen, R.; Chen, Y.; Waters, M.; Kim, S.; Berger, M. F.; Riely, G.; Ladanyi, M.; Chakravarty, D.; Schultz, N.; Jee, J.
10.1101/2024.03.31.587410 — genomics — Posted on 2024-04-01
4605 Loss of Paneth cells dysregulates gut ILC subsets and enhances weight gain response to high fat diet in a mouse model.
Joldrichsen, M. R.; Kim, E.; Steiner, H. E.; Jeong, Y. J.; Premanandan, C.; Hsueh, W.; iouzenkova, O.; Cormet-Boyaka, E.; Boyaka, P.
10.1101/2024.03.29.587349 — immunology — Posted on 2024-04-01
4606 Non-invasive neuromodulation of cerebello-hippocampal volume-behavior relationships
Magalhaes, T. N. C.; Maldonado, T.; Jackson, T. B.; Hicks, T. H.; Herrejon, I. A.; Rezende, T. J. R.; Symm, A. C.; Bernard, J. A.
10.1101/2024.03.29.587400 — neuroscience — Posted on 2024-04-01
4607 Gender, interdisciplinary graduate training, and confidence working in teams
Lu, L. T.; Palucki Blake, L.; Eyler, J. R.; Verduzco, R.; Biswal, S. L.; Bennett, G. N.; Silberg, J. J.
10.1101/2024.03.30.587416 — scientific communication and education — Posted on 2024-04-01
4608 Premeiotic 24-nt phasiRNAs are present in the Zea genus and unique in biogenesis mechanism and molecular function
Zhan, J.; Belanger, S.; Lewis, S.; Teng, C.; McGregor, M.; Beric, A.; Schon, M. A.; Nodine, M. D.; Meyers, B. C.
10.1101/2024.03.29.587306 — plant biology — Posted on 2024-04-01
4609 Graft incompatibility between pepper and tomato can be attributed to genetic incompatibility between diverged immune systems
Thomas, H. R.; Gevorgyan, A.; Hermanson, A.; Yanders, S.; Erndwein, L.; Norman-Ariztia, M.; Sparks, E. E.; Frank, M. H.
10.1101/2024.03.29.587379 — plant biology — Posted on 2024-04-01
4610 An ALS Therapeutic Assembly Modulator Target in Peripheral Blood Mononuclear Cells: Implications for ALS Pathophysiology, Therapeutics, and Diagnostics
Yu, S.; Michon, M.; Lingappa, A. F.; Paulvannan, K.; Solas, D.; Staats, K. A.; Ichida, J.; Dey, D.; Rosenfeld, J.; Lingappa, V. R.
10.1101/2024.03.28.587289 — physiology — Posted on 2024-04-01
4615 Harnessing Chemical Space Neural Networks to Systematically Annotate GPCR ligands
Hansson, F. G.; Madsen, N. G.; Hansen, L. G.; Jakociunas, T.; Lengger, B.; Keasling, J. D.; Jensen, M. K.; Acevedo-Rocha, C. G.; Jensen, E. D.
10.1101/2024.03.29.586957 — bioinformatics — Posted on 2024-04-01
4619 IL-10 dependent adaptation allows macrophages to adjust inflammatory responses to TLR4 stimulation history
Bongartz, H.; Bradfield, C. J.; Gross, J. L.; Fraser, I.; Nita-Lazar, A.; Meier-Schellersheim, M.
10.1101/2024.03.28.587272 — immunology — Posted on 2024-04-01
4620 Developmentally stable representations of naturalistic image structure in macaque visual cortex
Lee, G. M.; Rodriguez Deliz, C. L.; Bushnell, B. N.; Majaj, N. J.; Movshon, J. A.; Kiorpes, L.
10.1101/2024.02.24.581889 — neuroscience — Posted on 2024-04-01
4621 Role of the NOS-cGMP pathways in time-dependent sensitization of behavioral responses in zebrafish
de Souza, E. B.; Heymbeeck, J. A. A.; Feitosa, L. M.; Xavier, A. G. O.; Campos, K. d. S.; dos Santos Rodrigues, L. d. S.; de Freitas, L. M.; do Carmo Silva, R. X.; Ikeda, S. R.; Silva, S. d. N. d. S.; Rocha, S. P.; do Nascimento, W. L.; Moraes, E. R. d. S.; Herculano, A. M.; Maximino, C.; Pereira, A.; Lima-Maximino, M.
10.1101/2024.03.27.586937 — neuroscience — Posted on 2024-04-01
4622 A split-GAL4 driver line resource for Drosophila CNS cell types
Meissner, G. W.; Vannan, A.; Jeter, J.; Close, K.; DePasquale, G. M.; Dorman, Z.; Forster, K.; Beringer, J. A.; Gibney, T. V.; Hausenfluck, J. H.; He, Y.; Henderson, K.; Johnson, L.; Johnston, R. M.; Ihrke, G.; Iyer, N.; Lazarus, R.; Lee, K.; Li, H.-H.; Liaw, H.-P.; Melton, B.; Miller, S.; Motaher, R.; Novak, A.; Ogundeyi, O.; Petruncio, A.; Price, J.; Protopapas, S.; Tae, S.; Taylor, J.; Vorimo, R.; Yarbrough, B.; Zeng, K. X.; Zugates, C. T.; Dionne, H.; Angstadt, C.; Ashley, K.; Cavallaro, A.; Dang, T.; Gonzalez, G. A.; Hibbard, K. L.; Huang, C.; Kao, J.-C.; Laverty, T.; Mercer, M.; Perez, B
10.1101/2024.01.09.574419 — neuroscience — Posted on 2024-04-01
4624 Emergent effects of synaptic connectivity on the dynamics of global and local slow waves in large-scale thalamocortical network model of the human brain
Marsh, B.; Zuloaga, M. G. N.; Rosen, B. Q.; Sokolov, Y.; Delanois, J. E.; Gonzalez, O. C.; Krishnan, G. P.; Halgren, E.; Bazhenov, M.
10.1101/2023.10.15.562408 — neuroscience — Posted on 2024-04-01
4630 A mechanism that transduces lysosomal damage signals to stress granule formation for cell survival
Jia, J.; Duran, J.; Poolsup, S.; Allers, l.; Leums, M.; cheng, q.; Salemi, M.; Phinney, B.
10.1101/2024.03.29.587368 — cell biology — Posted on 2024-04-01
4631 WITHDRAWN: Mitochondrial genome variation affects humoral and cell-mediated innate immune responses and infection outcomes
Salminen, T. S.; Vesala, L.; Basikhina, Y.; Kutzer, M.; Tuomela, T.; Lucas, R.; Monteith, K.; Prakash, A.; Tietz, T.; Vale, P. F.
10.1101/2022.07.19.500574 — immunology — Posted on 2024-04-01
4635 Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment
Modica, G.; Tejeda-Valencia, L.; Sauvageau, E.; Maes, J.; Skorobogata, O.; Lefrancois, S.
10.1101/2024.04.01.587555 — cell biology — Posted on 2024-04-01
4636 Proactive selective attention across competition contexts
Aguado-Lopez, B.; Palenciano, A. F.; Penalver, J. M. G.; Diaz-Gutierrez, P.; Lopez-Garcia, D.; Avancini, C.; Ciria, L. F.; Ruz, M.
10.1101/2024.02.06.579112 — neuroscience — Posted on 2024-04-01
4638 Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein
Pimm, M. L.; Haarer, B. K.; Nobles, A. D.; Haney, L. M.; Marcin, A. G.; Eligio, M. A.; Henty-Ridilla, J. L.
10.1101/2023.05.04.539490 — cell biology — Posted on 2024-04-01
4639 Calcium (Ca2+) fluxes at Mitochondria-ER Contact Sites (MERCS) are a new target of senolysis in Therapy-Induced Senescence (TIS).
Puebla-Huerta, A.; Huerta, H.; Quezada-Gutierrez, C.; Morgado-Caceres, P.; Casanova-Canelo, C.; Linsambarth, S.; Diaz-Rivera, O.; Lopez-Dominguez, J. A.; Rodriguez-Lopez, S.; Bustos, G.; Silva-Pavez, E.; Lovy, A.; Quiroz, G.; Gonzalez-Seguel, C.; Salas-Huenuleo, E.; Kogan, M.; Molgo, J.; Zakarian, A.; Villalba, J. M.; Gonzalez-Billault, C.; Ahumada-Castro, U.; Cardenas, J. C.
10.1101/2024.03.31.587471 — cell biology — Posted on 2024-04-01
4641 Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1
Johnson, D.; Colijn, S.; Richee, J.; Yano, J.; Burns, M.; Davis, A. E.; Pham, V. N.; Saric, A.; Jain, A.; Yin, Y.; Castranova, D.; Melani, M.; Fujita, M.; Grainger, S.; Bonifacino, J. S.; Weinstein, B. M.; Stratman, A. N.
10.1101/2024.04.01.587559 — cell biology — Posted on 2024-04-01
4643 Broadly neutralizing antibodies against emerging delta-coronaviruses
Rexhepaj, M.; Park, Y.-J.; Perruzza, L.; Asarnow, D.; McCallum, M.; Culap, K.; Saliba, C.; Leoni, G.; Balmeli, A.; Yoshiyama, C.; Dickinson, M. S.; Quispe, J.; Brown, J. T.; Tortorici, M. A.; Sprouse, K. R.; Taylor, A. L.; Starr, T. N.; Corti, D.; Begnini, F.; Veesler, D.
10.1101/2024.03.27.586411 — biochemistry — Posted on 2024-04-01
4646 Protective role of Pten downregulation in Huntington's Disease models
Nisha, ; Thapliyal, D.; Gohil, B.; Modak, A. S.; Ahuja, S.; Singh, N. T.; Sahu, B. S.; Singh, M. D.
10.1101/2024.03.28.587147 — neuroscience — Posted on 2024-04-01
4647 PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA
Jana, S.; Mondal, M.; Mahale, S.; Gupta, B.; Prasasvi, K. R.; Kandasami, L.; Jha, N.; Chowdhury, A.; Santosh, V.; Kanduri, C.; Somasundaram, K.
10.1101/2023.04.11.536370 — cancer biology — Posted on 2024-04-01
4648 Loss of genetic variation and sex determination system in North American northern pike characterized by whole-genome resequencing
Johnson, H. A.; Rondeau, E. B.; Sutherland, B. J. G.; Minkley, D. R.; Leong, J. S.; Whitehead, J.; Despins, C. A.; Gowen, B. E.; Collyard, B. J.; Whipps, C. M.; Farrell, J. M.; Koop, B. F.
10.1101/2020.06.18.157701 — genomics — Posted on 2024-04-01
4653 Long-Read Structural and Epigenetic Profiling of a Kidney Tumor-matched Sample with Nanopore Sequencing and Optical Genome Mapping
Margalit, S.; Tulpova, Z.; Detinis Zur, T.; Michaeli, Y.; Deek, J.; Nifker, G.; Haldar, R.; Gnatek, Y.; Omer, D.; Dekel, B.; Grunwald, A.; Ebenstein, Y.
10.1101/2024.03.31.587463 — genomics — Posted on 2024-04-01