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Archive, 2024-12

2 RNAGenesis: Foundation Model for Enhanced RNA Sequence Generation and Structural Insights
Zhang, Z.; Chao, L.; Jin, R.; Zhang, Y.; Zhou, G.; Yang, Y.; Yang, Y.; Huang, K.; Yang, Q.; Xu, Z.; Zhang, X.; Cong, L.; Wang, M.
10.1101/2024.12.30.630826 — bioinformatics — Posted on 2024-12-31
4 Immune Checkpoint Molecules as Biomarkers of Staphylococcus aureus Bone Infection and Clinical Outcome
Saito, M.; McDonald, K. A.; Grier, A. K.; Meghwani, H.; Rangel-Moreno, J.; Becerril-Villanueva, E.; Gamboa-Dominguez, A.; Bruno, J.; Beck, C. A.; Proctor, R. A.; Kates, S. L.; Schwarz, E. M.; Muthukrishnan, G.
10.1101/2024.12.30.630837 — immunology — Posted on 2024-12-31
6 Impact of bacterial translocation in stroke outcome. Soluble CD14 as early clinical marker and effect of TLR4
Granados-Martinez, C.; Alfageme-Lopez, N.; Diaz-Benito, B.; Moraga, A.; Sevillano-Fernandez, D.; Alou-Cervera, L.; Fernandez-Valle, M. E.; Castejon-Ferrer, D.; Calleja-Castano, P.; Moro, M. A.; Hernandez-Jimenez, M.; Lizasoain, I.; Pradillo, J. M.
10.1101/2024.12.30.630676 — neuroscience — Posted on 2024-12-31
7 Self-Documenting Plasmids
Hernandez, S. I.; Peccoud, S. J.; Berezin, C.-T.; Peccoud, J.
10.1101/2024.10.29.620927 — synthetic biology — Posted on 2024-12-31
8 Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy
Turkalj, S.; Stoilova, B.; Groom, A. J.; Radtke, F. A.; Mecklenbrauck, R.; Jakobsen, N. A.; Lachowiez, C. A.; Metzner, M.; Usukhbayar, B.; Salazar, M. A.; Zeng, Z.; Loghavi, S.; Marvin-Peek, J.; Koerber, V.; Ravandi, F.; Issa, G.; Kadia, T.; Symeonido, V.; de Groot, A. P.; Kantarjian, H.; Takahashi, K.; Konopleva, M.; DiNardo, C. D.; Vyas, P.
10.1101/2024.12.30.630700 — cancer biology — Posted on 2024-12-31
14 Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease
Li, Y.; Huang, C.; Fan, W.; Hammad, S.; Berger, L.; Geraud, C.; Yao, Y.; Link, F.; Tong, C.; Nwosu, Z. C.; Erdoesi, P.; Pioronska, W.; Gould, K.; Meyer, C.; Feng, R.; Liu, H.; Shao, C.; Sun, B.; Ding, H.; Liebe, R.; Ebert, M. P. A.; Weng, H.-L.; Gao, C.; ten Dijke, P.; Dooley, S.; Wang, S.
10.1101/2024.02.17.580798 — cell biology — Posted on 2024-12-31
15 A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense
Chang, R. B.; Toyoda, H. C.; Hobbs, S. J.; Richmond-Buccola, D.; Wein, T.; Burger, N.; Chouchani, E. T.; Sorek, R.; Kranzusch, P. J.
10.1101/2024.12.30.630793 — microbiology — Posted on 2024-12-31
22 A new mechanochemical vertex model with Ca2+ signalling, for apical constriction in neural tube closure
Chakraborty, A.; Phillips, T. N.; Christodoulou, N.; Skourides, P.; Maini, P.; Baker, R.; Kaouri, K.
10.1101/2024.12.31.630855 — systems biology — Posted on 2024-12-31
24 Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma
Shishikura, K.; Li, J.; Chen, Y.; McKnight, N. R.; Bustin, K. A.; Barr, E. W.; Chilkamari, S. R.; Ayub, M.; Kim, S. W.; Lin, Z.; Hu, R.-M.; Hicks, K.; Wang, X.; O'Rourke, D. M.; Bollinger, J. M.; Binder, Z. A.; Parsons, W. H.; Martemyanov, K. A.; Liu, A.; Matthews, M. L.
10.1101/2024.12.19.629450 — biochemistry — Posted on 2024-12-31
27 Sex-dependent influence of major histocompatibility complex diversity on fitness in a social mammal
Schubert, N.; Nichols, H. J.; Mwanguhya, F.; Businge, R.; Kyambulima, S.; Mwesige, K.; Hoffman, J. I.; Cant, M. A.; Winternitz, J. C.
10.1101/2024.12.18.629201 — evolutionary biology — Posted on 2024-12-31
28 Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium
Medina-Feliciano, J. G.; Valentin-Tirado, G.; Luna-Martinez, K.; Beltran-Rivera, A.; Miranda-Negron, Y.; Garcia-Arraras, J. E.
10.1101/2024.07.01.601561 — developmental biology — Posted on 2024-12-31
29 Single-cell RNA sequencing analysis reveals new insights for intersex gonad initiation and early sex differentiation of goats
Cao, X.; Zhang, Y.; Xu, D.; Du, M.; Lin, X.; Leng, L.; Campo, F. P.; Zhang, L.; Sun, M.; Gao, X.; He, J.; Zhao, Q.; Wang, J.; Zhao, J.; Li, H.
10.1101/2024.12.31.630861 — developmental biology — Posted on 2024-12-31
31 Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signalling pathway.
Bose, M.; Talwar, I.; Suresh, V.; Mishra, U.; Biswas, S.; Yadav, A.; Suryavanshi, S. T.; Hippenmeyer, S.; Tole, S.
10.1101/2023.11.30.569337 — neuroscience — Posted on 2024-12-31
33 X-ray Diffraction Reveals Periodicity in Murine Neocortex
Murokh, S.; Willerson, E. N.; Lazarev, A.; Lazarev, P.; Brumberg, J. C.
10.1101/2024.10.13.618071 — neuroscience — Posted on 2024-12-31
35 Discovery of neuronal cell types by pairing whole cell reconstructions with RNA expression profiles
Ferreira, T. A.; Eddison, M.; Copeland, M.; Lay, M.; Tenshaw, E.; Weldon, M.; Schauder, D.; Olbris, D. J.; Rokicki, K.; Spruston, N.; Tillberg, P. W.; Korff, W.; Dudman, J. T.; The MouseLight Project Team,
10.1101/2024.12.30.630829 — neuroscience — Posted on 2024-12-31
37 Sleep patterns predicting stress resilience are dependent on sex
Bush, B. J.; Mohamed, A.; Andrews, E.-J.; Cain, G.; Fawole, A.; Johnson, H.; Arocho, A.; Qiao, Z.; Paul, K. N.; Ehlen, J. C.
10.1101/2024.12.30.630808 — neuroscience — Posted on 2024-12-31
38 Personalized cue-reactive delta-theta oscillations guide deep brain stimulation for opioid use disorder
Qiu, L.; Nho, Y.; Seilheimer, R. L.; Kim, M. J.; Tufanoglu, A.; WILLIAMS, N.; Wexler, A.; David, O.; Katherine, S. W.; Pesaran, B.; Evins, A. E.; Richardson, M.; Childress, A. R.; Halpern, C. H.
10.1101/2024.12.30.630822 — neuroscience — Posted on 2024-12-31
39 A generative framework for enhanced cell-type specificity in rationally designed mRNAs
Khoroshkin, M. S.; Zinkevich, A.; Aristova, E.; Yousefi, H.; Lee, S. B.; Mittmann, T.; Manegold, K.; Penzar, D.; Raleigh, D. R.; Kulakovskiy, I. V.; Goodarzi, H.
10.1101/2024.12.31.630783 — systems biology — Posted on 2024-12-31
40 Novel Genetically Encoded Probes for Functional Imaging of Cell Signaling by Polarization Microscopy
Miclea, P. S.; Nagy Markova, V.; Van den Eynde, R.; Vandenberg, W.; Sakhi, A.; Bondar, A.; Myskova, J.; Dedecker, P.; Lazar, J.
10.1101/2024.02.23.581811 — physiology — Posted on 2024-12-31
41 Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography
Zhou, H.; Hutchings, J.; Shiozaki, M.; Zhao, X.; Doolittle, L. K.; Yang, S.; Yan, R.; Jean, N.; Riggi, M.; Yu, Z.; Villa, E.; Rosen, M. K.
10.1101/2024.12.01.626131 — biophysics — Posted on 2024-12-31
42 ProteoPlotter: an executable proteomics visualization tool compatible with Perseus
Olabisi-Adeniyi, E.; McAlister, J.; Ferretti, D.; Cox, J.; Geddes-McAlister, J.
10.1101/2024.12.30.630796 — bioinformatics — Posted on 2024-12-31
44 Replication stress increases de novo CNVs across the malaria parasite genome
Brown, N. J.; Luniewski, A.; Yu, X.; Warthan, M. D.; Liu, S.; Zulawinska, J.; Ahmad, S.; Congdon, M.; Santos, W.; Xiao, F.; Guler, J. L.
10.1101/2024.12.19.629492 — genomics — Posted on 2024-12-31
45 Direction and modality of transcription changes caused by TAD boundary disruption in Slc29a3/Unc5b locus depends on tissue-specific epigenetic context
Salnikov, P. A.; Belokopytova, P. S.; Yan, A. P.; Viesna, E.; Korablev, A. N.; Serova, I. A.; Lukyanchikova, V. A.; Stepanchuk, Y. K.; Torgunakov, N. Y.; Tikhomirov, S. A.; Fishman, V. S.
10.1101/2024.08.16.608309 — genetics — Posted on 2024-12-31
46 Characterization of both major histocompatibility complex classes in a wild social mammal: the banded mongoose
Schubert, N.; Nichols, H. J.; Mwanguhya, F.; Businge, R.; Kyambulima, S.; Mwesige, K.; Cant, M. A.; Winternitz, J. C.
10.1101/2024.12.14.628504 — genetics — Posted on 2024-12-31
47 Local nutrient addition drives plant biodiversity losses but not biotic homogenization in global grasslands
Chen, Q.; Blowes, S.; Harpole, S.; Ladouceur, E.; Borer, E.; MacDougall, A.; Bakker, J. D.; Tognetti, P. M.; Seabloom, E. W.; Daleo, P.; Martina, J.; Roscher, C.; Adler, P.; Wheeler, G.; Estrada, C.; Stevens, C.; Veen, C.; Risch, A. C.; Donohue, I.; Hautier, Y.; Wardle, G.; Haider, S.; Hersch-Green, E.; Niu, Y.; Peri, P. L.; Power, S. A.; Eskelinen, A.; Gruner, D.; Olde Venterink, H.; D'Antonio, C.; Cadotte, M.; Eisenhauer, N.; Virtanen, R.; Catford, J.; Morgan, J.; Tedder, M.; Bagchi, S.; Maria, C.; Bugalho, M.; Knops, J.; Dickman, C.; Hagenah, N.; Jentsch, A.; Macek, P.; Osborne, B.; Laanist
10.1101/2024.03.27.586835 — ecology — Posted on 2024-12-31
49 A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease
Melo Ferreira, R.; Gisch, D. L.; Phillips, C. L.; Cheng, Y.-H.; Asthana, M.; Lake, B. B.; Bowen, W. S.; Fang, F.; Asghari, M.; Sabo, A.; Barwinska, D.; Ferkowicz, M. J.; Toto, R. D.; Sedor, J. R.; Rosas, S. E.; Bjornstad, P.; Hodgin, J. B.; Alpers, C. E.; Sarder, P.; Himelfarb, J.; Schaub, J. A.; Nair, V.; Winfree, S.; Sutton, T. A.; Kelly, K. J.; and The Kidney Precision Medicine Project, ; Kretzler, M.; Jain, S.; El-Achkar, T. M.; Dagher, P. C.; Eadon, M. T.
10.1101/2024.09.27.615250 — cell biology — Posted on 2024-12-31
50 Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease
Li, Y.; Huang, C.; Fan, W.; Hammad, S.; Berger, L.; Geraud, C.; Yao, Y.; Link, F.; Tong, C.; Nwosu, Z. C.; Erdoesi, P.; Pioronska, W.; Gould, K.; Meyer, C.; Feng, R.; Liu, H.; Shao, C.; Sun, B.; Ding, H.; Liebe, R.; Ebert, M. P. A.; Weng, H.-L.; Gao, C.; ten Dijke, P.; Dooley, S.; Wang, S.
10.1101/2024.02.17.580798 — cell biology — Posted on 2024-12-31
52 The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism
Lapao, A.; Johnson, L. S.; Trachsel-Moncho, L.; Singh, S.; Ng, M. Y.; Nakken, S.; Eskelinen, E.-L.; Simonsen, A.
10.1101/2024.12.30.630740 — cell biology — Posted on 2024-12-31
54 Hepatitis E Virus-induced antiviral response by plasmacytoid dendritic cells is modulated by the ORF2 protein
Joshi, G.; Decembre, E.; Brocard, J.; Montpellier, C.; Ferrie, M.; Allatif, O.; Mehnert, A.-K.; Pons, J.; Galiana, D.; Dao Thi, V. L.; Jouvenet, N.; Cocquerel, L.; Dreux, M.
10.1101/2024.04.12.589258 — immunology — Posted on 2024-12-31
55 Phosphate Starvation-Induced CORNICHON HOMOLOG 5 as Endoplasmic Reticulum Cargo Receptor for PHT1 Transporters in Arabidopsis
Chiu, C.-Y.; Tsai, C.-D.; Wang, J.-Y.; Tsai, M.-H.; McGinness, A. J.; Lung, H.-F.; Kanno, S.; Kriechbaumer, V.; Liu, T.-Y.
10.1101/2024.06.20.599911 — plant biology — Posted on 2024-12-31
57 Spatial Transcriptomic Profiling Of Advanced Ovarian Clear Cell Carcinoma Reveals Intra-Tumor Heterogeneity In Epithelial-Mesenchymal Gradient
Truong Le, T.; Yi-Te Wang, D.; Chen, K.-C.; Yan, S. R.-G.; Chu, P.-Y.; Tan, T. Z.; Chiu, Y.-C.; Sheu, J.-Y.; Huang, C.-H.; Ye, J.; Tai, Y.-T.; Juan, H.-F.; Tsai, F.-C.; Lin, W.-C.; Wei, L.-H.; Huang, R. Y.-J.
10.1101/2024.10.19.619181 — cancer biology — Posted on 2024-12-31
59 I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation
Fu, Z.; Geisbrecht, B. V.; Bouyain, S.; Dyda, F.; Chrzas, J. J.; Kandavelu, P.; Miller, D. J.; Wang, B.-C.
10.1101/2024.12.10.627855 — biophysics — Posted on 2024-12-31
61 Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate
Borar, P.; Biswas, T.; Chaudhuri, A.; Rao, P. T.; Raychaudhuri, S.; Huxford, T.; Chakrabarti, S.; Ghosh, G.; Polley, S.
10.1101/2023.06.27.546692 — biochemistry — Posted on 2024-12-31
64 KLP-19 controls microtubule length in the spindle midzone of C. elegans, affecting spindle dynamics and force transmission during mitosis.
Zimyanin, V.; Magaj, M. M.; Manzi, N. I.; Yu, C.-H.; Gibney, T. V.; Chen, Y.-Z.; Mustafa, B.; Horton, X.; Siller, K.; Pani, A. M.; Needleman, D.; Dickinson, D. J.; Redemann, S.
10.1101/2023.10.26.564275 — cell biology — Posted on 2024-12-31
66 Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin
Ishimoto, N.; Wong, J. L. C.; Singh, N.; Shirran, S.; He, S.; Seddon, C.; Wright, O.; Balsalobre, C.; Sonani, R. R.; Clements, A.; Egelman, E.; frankel, g.; Beis, K.
10.1101/2024.12.30.630807 — microbiology — Posted on 2024-12-31
67 The genetic diversity and populational specificity of the human gut virome at single nucleotide resolution
Wang, X.; Dong, Q.; Huang, P.; Yang, S.; Gao, M.; Zhang, C.; Zhang, C.; Deng, Y.; Huang, Z.; Ma, B.; Jiao, Y.; Zhou, Y.; Wu, T.; Zou, H.; Shi, J.; Sheng, Y.; Wang, Y.; Tang, L.; Hu, S.; Duan, Y.; Sun, W.; Chen, W.; Zhai, Q.; Kong, X.; Chen, L.
10.1101/2024.12.30.630844 — microbiology — Posted on 2024-12-31
69 Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines
Wei, S.; Cantor, A. J.; Walleshauser, J.; Mepani, R.; Melton, K.; Bans, A.; Khekare, P.; Gupta, S.; Wang, J.; Soares, C.; Kiwan, R.; Lee, J.; McCawley, S.; Jani, V.; Leong, W. I.; Shahi, P. K.; Chan, J.; Boivin, P.; Otoupal, P.; Pattnaik, B. R.; Gamm, D. M.; Saha, K.; Gowen, B. G.; Haak-Frendscho, M.; Janatpour, M. J.; Silverman, A. P.
10.1101/2024.12.30.630799 — pharmacology and toxicology — Posted on 2024-12-31
73 ProteoPlotter: an executable proteomics visualization tool compatible with Perseus
Olabisi-Adeniyi, E.; McAlister, J.; Ferretti, D.; Cox, J.; Geddes-McAlister, J.
10.1101/2024.12.30.630796 — bioinformatics — Posted on 2024-12-31
74 Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes
Wang, S.-T.; Anahtar, M.; Kim, D. M.; Samad, T. S.; Zhang, C. M.; Patel, S.; Ko, H.; Ngambenjawong, C.; Wang, C. S.; Kirkpatrick, J. D.; Kumar, V.; Fleming, H. E.; Bhatia, S. N.
10.1101/2024.12.30.630769 — bioengineering — Posted on 2024-12-31
75 Genome-Wide Associations within Diverse Wild Apple Germplasm for Postharvest Blue Mold Resistance to Penicillium expansum
Whitt, L.; Bennett, J. S.; Collum, T. D.; Evans, B.; Raines, D.; Gutierrez, B.; Janisiewicz, W. J.; Jurick, W. M.; Gottschalk, C.
10.1101/2024.12.30.629434 — genetics — Posted on 2024-12-31
76 Analysis of mouse lens morphological and proteomic abnormalities following depletion of βB3-crystallin
Rayee, D.; Wilmarth, P. A.; VanSlyke, J. K.; Zientek, K.; Reddy, A. P.; Musil, L. S.; David, L. L.; Cvekl, A.
10.1101/2024.12.30.630781 — developmental biology — Posted on 2024-12-31
77 Donor Strand Complementation and Calcium Ion Coordination Drive the Chaperone-free Polymerization of Archaeal Cannulae
Sleutel, M.; Sonani, R. R.; Miller, J.; Wang, F.; Gonzalez Socorro, A.; Chen, Y.; Martin, R.; Demeler, B.; Rudolph, M. J.; Alva, V.; Remaut, H.; Egelman, E.; Conticello, V.
10.1101/2024.12.30.630787 — microbiology — Posted on 2024-12-31
78 Transient glycan-shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques
Morris, D. J.; Gorman, J.; Zhou, T.; Lora, J.; Connell, A. J.; Li, H.; Liu, W.; Roark, R. S.; Campion, M. S.; Carey, J. W.; Habib, R.; Li, Y.; Martella, C. L.; Park, Y.; Singh, A.; Sowers, K. J.; Teng, I.-T.; Wang, S.; Chohan, N.; Ding, W.; Lauer, C.; Lewis, E.; Mason, R. D.; Rando, J. M.; Peyton, L.; Schramm, C. A.; Wagh, K.; Korber, B.; Seaman, M. S.; Douek, D. C.; Haynes, B. F.; Kulp, D. W.; Roederer, M.; Hahn, B. H.; Kwong, P. D.; Shaw, G. M.
10.1101/2024.12.30.630768 — microbiology — Posted on 2024-12-31
80 Osmolarity regulates C. elegans egg-laying behavior via parallel chemosensory and biophysical mechanisms
Medrano, E.; Jendrick, K.; McQuirter, J.; Moxham, C.; Rajic, D.; Rosendorf, L.; Stilman, L.; Wilright, D.; Collins, K. M.
10.1101/2024.12.30.630790 — neuroscience — Posted on 2024-12-31
81 Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
Lee, Y.-K.; Xiao, C.; Zhou, X.; Wang, L.; McReynolds, M. G.; Wu, Z.; Purisic, E.; Kim, H.; Li, X.; Pang, Z. P.; Dai, J.; Peng, J.; Yang, N.; Yue, Z.
10.1101/2024.12.30.630813 — neuroscience — Posted on 2024-12-31
84 Rewriting nuclear epigenetic scripts in mitochondrial diseases as a strategy for heteroplasmy control
Perez, M. J.; Colombo, R. B.; Real, S. M.; Branham, M. T.; Laurito, S. R.; Moraes, C. T.; Mayorga, L.
10.1101/2024.12.30.630791 — genomics — Posted on 2024-12-31
85 Deciphering the patterns and timing of diversification of the genus Melanastera (Hemiptera: Psylloidea: Liviidae) in the Neotropics
Serbina, L.; Burckhardt, D.; Petrakova Dusatkova, L.; Queiroz, D.; Goldenberg, R.; Schuler, H.; Percy, D.; Malenovsky, I.
10.1101/2024.12.30.630774 — evolutionary biology — Posted on 2024-12-31
87 An Interbacterial Cysteine Protease Toxin Inhibits Cell Growth by Targeting Type II DNA Topoisomerases GyrB and ParE
Song, P.-Y.; Tsai, C.-E.; Chen, Y.-C.; Chen, P.-P.; Wang, T.-H.; Hu, C.-Y.; Chen, P.-Y.; Ku, C.; Hsia, K.-C.; Ting, S.-Y.
10.1101/2024.12.30.630690 — microbiology — Posted on 2024-12-31
89 Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6
Taha, T. Y.; Ezzatpour, S.; Hayashi, J. M.; Ye, C.; Zapatero-Belinchon, F. J.; Rosecrans, J. A.; Kimmerly, G. R.; Chen, I. P.; Walcott, K.; Kurianowicz, A.; Jorgens, D. M.; Chaplin, N. R.; Choi, A.; Buchholz, D. W.; Sahler, J.; Hilt, Z. T.; Imbiakha, B.; Vagi-Szmola, C.; Montano, M.; Stevenson, E.; Gordon, M.; Swaney, D. L.; Krogan, N. J.; Martinez-Sobrido, L.; Aguilar, H. C.; Ott, M.
10.1101/2024.12.30.628795 — microbiology — Posted on 2024-12-30
91 A Linear Mixed Effects Model for Evaluating Synthetic Gene Circuits
Partipilo, G.; Coleman, S. M.; Gao, Y.; Miniel Mahfoud, I. E.; Wilke, C. O.; Alper, H. S.; Keitz, B. K.
10.1101/2024.12.30.630778 — synthetic biology — Posted on 2024-12-30
95 Structural basis for ring-opening fluorescence by the RhoBAST RNA aptamer.
Siwik, S. H.; Wierzba, A. J.; Lennon, S. R.; Olenginski, L. T.; Palmer, A. E.; Batey, R. T.
10.1101/2024.12.30.630784 — biochemistry — Posted on 2024-12-30
98 Caspofungin binding to iron compromises its antifungal efficacy against Candida albicans
Pedras, A.; Malta Luis, C.; Lima, L. M. P.; Mil-Homens, D.; Amaral, C.; Duarte, A. G.; Antunes, W.; Gaspar-Cordeiro, A.; Louro, R. O.; Lamosa, P.; Soares, C. M.; Lousa, D.; Pimentel, C.
10.1101/2024.12.30.630750 — microbiology — Posted on 2024-12-30
101 A nucleotide code governs Lis1's ability to relieve dynein autoinhibition
Geohring, I. C.; Chai, P.; Iyer, B. R.; Ton, W. D.; Yang, J.; Ide, A. H.; George, S. C.; Bagri, J. S.; Baird, S. V.; Zhang, K.; Markus, S. M.
10.1101/2024.12.30.630615 — biochemistry — Posted on 2024-12-30
102 LC-MS/MS characterization of SOBERANA(R)02, a receptor binding domain-tetanus toxoid conjugate vaccine against SARS-CoV-2
Martinez, O.; Santana-Medero, D.; Pousa, S.; Soubal, J. P.; Rodriguez-Ulloa, A.; Ramos-Bermudez, P. E.; Besada, V.; Garrido, R.; Carvalho, P.; Batista, M.; Zetl, K.; Wisniewski, J.; Boggiano, T.; Valdes-Balbin, Y.; Garcia-Rivera, D.; G. Rivera, D.; Verez Bencomo, V.; Gonzalez, L. J.
10.1101/2024.12.27.630511 — biochemistry — Posted on 2024-12-30
105 Hydrogen sulfide (H2S) coordinates redox balance, carbon metabolism, and mitochondrial bioenergetics to suppress SARS-CoV-2 infection.
Agrawal, R.; Pal, V. K.; S, S. K.; Menon, G. J.; Singh, I. R.; Malhotra, N.; S, N. C.; Ganesh, K.; Rajmani, R. S.; Seshasayee, A. S. N.; Chandra, N.; Joshi, M. B.; Singh, A.
10.1101/2024.12.29.630646 — microbiology — Posted on 2024-12-30
110 Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression
Zhang, R.; Rodriguez-Rodriguez, P.; Medrihan, L.; Chang, J. C.; Ferraro, T.; Del Cioppo Vasques, P.; McCabe, K.; Wang, W.; Menard, C.; Cathomas, F.; Chan, K. L.; Parise, L. F.; Shaham, S.; Roussarie, J.-P.; Troyanskaya, O. G.; Russo, S.; Milosevic, A.
10.1101/2024.12.30.630684 — neuroscience — Posted on 2024-12-30
112 CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias
Fleming, T. J.; Antoszewski, M.; Lambo, S.; Gundry, M. C.; Piussi, R.; Wahlster, L.; Shah, S.; Reed, F. E.; Dong, K. D.; Paulo, J. A.; Gygi, S. P.; Mimoso, C.; Goldman, S. R.; Adelman, K.; Perry, J. A.; Pikman, Y.; Stegmaier, K.; Barrachina, M. N.; Machlus, K. R.; Hovestadt, V.; Arruda, A.; Minden, M. D.; Voit, R. A.; Sankaran, V. G.
10.1101/2024.12.30.630680 — cancer biology — Posted on 2024-12-30
117 Long-term immune changes after COVID-19 and the effect of BCG vaccination and latent infections on disease severity
Bendickova, K.; Papatheodorou, I.; Blazkova, G.; Helan, M.; Halakova, M.; Bednar, P.; Spearing, E.; Obermannova, L.; Stichova, J.; Heroldova, M. D.; Tomas, T.; Panovsky, R.; Sramek, V.; Zuani, M. D.; Vlkova, M.; Ruzek, D.; Kohoutkova, M. H.; Fric, J.
10.1101/2024.12.16.628601 — immunology — Posted on 2024-12-30
122 Structural basis of phosphate export by human XPR1
Wang, Y.; Wang, Y.; Yang, H.; Li, A.; Ma, D.; Shen, H.
10.1101/2024.12.30.630499 — biochemistry — Posted on 2024-12-30
123 A photoswitchable HaloTag for spatiotemporal control of fluorescence in living cells
Walterspiel, F.; Ugarte-Uribe, B.; Weidenhausen, J.; Dimitriadi, A.; Khan, A. U. M.; Müller, C. W.; Deo, C.
10.1101/2024.12.18.629107 — biochemistry — Posted on 2024-12-30
125 Cytosolic Carboxypeptidase 5 maintains mammalian ependymal multicilia to ensure proper homeostasis and functions of the brain
Dad, R.; Wang, Y.; Fang, C.; Chen, Y.; Zhang, Y.; Pan, X.; Zhang, X.; Swanekamp, E.; Patel, K.; Wolf, M. T. F.; Yuchi, Z.; Zhu, X.; Wu, H.-Y.
10.1101/2024.12.30.630763 — cell biology — Posted on 2024-12-30
126 Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling in Drosophila
Taoka, H.; Murakawa, T.; Kawaguchi, K.; Koizumi, M.; Kaminishi, T.; Sakamaki, Y.; Tanaka, K.; Harada, A.; Inoue, K.; Kanki, T.; Ohkawa, Y.; Fujita, N.
10.1101/2024.12.30.630714 — cell biology — Posted on 2024-12-30
128 Breast Cancer Remodels Lymphatics in Sentinel Lymph Nodes
Eichin, D.; Takeda, A.; Lehotina, D.; Kauko, A.; Uenaka, M.; Leppanen, M.; Elima, K.; Lonnberg, T.; Bostrom, P.; Koskivuo, I.; Aittokallio, T.; Hollmen, M.; Jalkanen, S.
10.1101/2024.12.30.630756 — immunology — Posted on 2024-12-30
129 Dissociable neurofunctional and molecular characterizations of reward and punishment sensitivity
Xu, T.; Zhu, C.; Zhou, X.; Chen, Z.; Gan, X.; Cui, X.; Zhou, F.; Zhang, R.; Zhao, W.; Zhang, X.; Chen, H.; He, Q.; Lei, X.; Qiu, J.; Feng, T.
10.1101/2024.12.30.630747 — neuroscience — Posted on 2024-12-30
133 Evaluation of Immunopharmacological Efficacy of Live Leishmania donovani Overexpressing Ld_ζ1domain for Protection Against Experimental Human Visceral Leishmaniasis
Bansal, R.; Shafi, S.; Garg, P.; Srivastava, A.; Garg, S.; Singhal, J.; Deethamvali Ghouse Peer, G.; Pati Pandey, R.; Basu, S.; Singh, S.
10.1101/2024.12.30.630021 — pathology — Posted on 2024-12-30
135 Single-cell analysis reveals distinct immune characteristics of hepatocellular carcinoma in HBV-positive versus HBV-negative cases
Liu, K.; Chen, E.; Liang, J.; Li, Y.; Cheng, B.; Shi, W.; Zhou, Z.; Zhou, W.; Tian, H.; Yang, D.; Shao, X.; Li, H.
10.1101/2024.12.30.630656 — bioinformatics — Posted on 2024-12-30
137 Exploring the Boundaries of Medulloblastoma Subgroups with Synthetic Data Generation
Prol-Castelo, G.; Tejada-Lapuerta, A.; Urda-Garcia, B.; Nunez-Carpintero, I.; Valencia, A.; Cirillo, D.
10.1101/2024.12.30.630738 — bioinformatics — Posted on 2024-12-30
143 Antimicrobial resistance, pathogenicity and virulence patterns of Escherichia coli isolated from cockroaches (Blattella germanica) across diverse environments: a public health concern
Sigma, S. H.; Ashraf, M. N.; Karmakar, S.; Rimi, S. S.; Chakraborty, S.; Siddique, M. P.; Hassan, J.; Islam, M. A.; Rahman, M. T.; Islam, M. S.; Hossain, M. T.
10.1101/2024.12.29.630637 — microbiology — Posted on 2024-12-30
144 Rapid identification of African swine fever virus in diagnostic samples using CRISPR-Cas
Kambakam, S.; Thomas, J.; Robbe-Austerman, S.; Shanmuganatham, K.; Palinski, R.
10.1101/2024.12.27.630508 — microbiology — Posted on 2024-12-30
145 Protists as mediators of complex microbial and viral associations
Schulz, F.; Yan, Y.; Weiner, A. K. M.; Ahsan, R.; Katz, L. A.; Woyke, T.
10.1101/2024.12.29.630703 — microbiology — Posted on 2024-12-30
146 Plasmodium falciparum expresses fewer var genes at lower levels during asymptomatic dry season infections than clinical malaria cases
Ceesay, S.; Kampmann, M.; Votborg-Novel, L.; Smedegaard Hansson, H.; Jensen, R. W.; Carrasquilla, M.; Cisse, H.; Turner, L.; Dabbas, U.; Ntalla, C.; Bandermann, S.; Doumbo, S. N.; Doumtabe, D.; Ongoiba, A.; Kayentao, K.; Traore, B.; Crompton, P. D.; Lavstsen, T.; Portugal, S.
10.1101/2024.12.30.630752 — microbiology — Posted on 2024-12-30
151 Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia
Broman, M.; Lanman, N. A.; Vickman, R. E.; Cresswell, G.; Kothandaraman, H.; Kolliegbo, A.; Paez Paez, J. S.; Glaser, A. P.; Helfand, B. T.; Henry, G.; Strand, D.; Franco, O.; Crawford, S.; Hayward, S. W.; Ratliff, T.
10.1101/2024.12.30.629739 — immunology — Posted on 2024-12-30
152 Layilin Regulates Treg Motility and Suppressive Capacity in Skin
Gouirand, V.; Clancy, S.; Macon, C.; Valle, J.; Pauli, M.; Truong, H.-A.; Cohen, J.; Kinet, M.; Lowe, M. M.; Lord, S. J.; Skruber, K.; Harris, H.; Kim, E.; Neuhaus, I.; Reif, K.; Zarrin, A. A.; Mullins, R. D.; Rosenblum, M.
10.1101/2024.12.30.630730 — immunology — Posted on 2024-12-30
159 Direct RNA Oxford Nanopore sequencing distinguishes between modifications in tRNA at the U34 position
Kusmirek, W.; Strozynska, N.; Martin-Arroyo Cerpa, P.; Dziergowska, A.; Leszczynska, G.; Nowak, R.; Adamczyk, M.
10.1101/2024.12.30.630739 — synthetic biology — Posted on 2024-12-30
160 Inhibition of constitutive activity of the atypical chemokine receptor ACKR3 by the small-molecule inverse agonist VUF16840
Bosma, R.; Nesheva, D.; Rijnsnburger, M.; Riemens, R.; Adamska, J. M.; Meyrath, M.; Mobach, S.; Buzink, C. M. L.; De Esch, I. J. P.; Szpakowska, M.; Wijtmans, M.; Chevigne, A.; Vischer, H. F.; Leurs, R.
10.1101/2024.12.30.630720 — pharmacology and toxicology — Posted on 2024-12-30
162 Transcriptional Dosage of Oncogenic KRAS Drives Lung Adenocarcinoma Cell States, Progression and Metastasis
Serresi, M.; Cetin, A. O.; Dramaretska, Y.; Kertalli, S.; Schmitt, M. J.; Naumann, H.; Zschummel, M.; Asselin-Labat, M.-L.; Maciel, L. F.; Declercq, J.; Marine, J.-C.; Gargiulo, G.
10.1101/2024.12.29.630643 — cancer biology — Posted on 2024-12-30
165 Haemodynamic impact of implant materials and anastomotic angle in peripheral vascular grafts
Schoenborn, S.; Lloyd, T.; Sivakumaran, Y.; Woodruff, M. A.; Fletcher, D. F.; Pirola, S.; Allenby, M. C.
10.1101/2024.12.18.629298 — bioengineering — Posted on 2024-12-30
166 Inverted topologies in sequential fitness landscapes enable evolutionary control
Chen, P.; Krishnan, N.; Stacy, A.; Weaver, D. T.; Barker-Clarke, R.; Hinczewski, M.; Maltas, J. A.; Scott, J. G.
10.1101/2024.12.29.630702 — evolutionary biology — Posted on 2024-12-30
168 Symbiotic Bacterial Partners for Chemical Defense are Vertically Transmitted in a Marine Sponge
Fujita, M.; Ise, Y.; Fukuoka, M.; Kimura, N.; Ninomiya, A.; Yoshitake, K.; Matsunaga, S.; Sakai, R.; Takada, K.
10.1101/2024.12.29.630706 — microbiology — Posted on 2024-12-30
169 Gut bacterial sphingolipid production modulates dysregulated skin lipid homeostasis
Lee, M.-T.; Tan, X.; Le, H.; Besler, K.; Thompson, S.; Harris-Tryon, T. A.; Johnson, E.
10.1101/2024.12.29.629238 — microbiology — Posted on 2024-12-30
172 Catestatin improves heart metabolic flexibility by promoting mitochondrial structure and function
Chirasani, V. R.; Kal, S.; Biswas, N.; Mahata, S.; Tang, K.; Pasqua, T.; Avolio, E.; Jati, S.; Bandyopadhyay, G.; Head, B. P.; Patel, H. H.; van den Bogaart, G.; Sahoo, D.; Senapati, S.; Mahata, S. K.
10.1101/2024.12.29.630689 — physiology — Posted on 2024-12-30
173 Model-based Bayesian inference of cancer dynamics from heterogenous longitudinal data
Santacatterina, G.; Bergamin, R.; Zucchetto, A.; Laureana, R.; Del Principe, M. I.; Gattei, V.; Egidi, L.; Caravagna, G.
10.1101/2024.12.30.630757 — cancer biology — Posted on 2024-12-30
174 CLCNet: a contrastive learning and chromosome-aware network for genomic prediction in plants
Huang, J.; Yang, Z.; Yin, M.; Li, C.; Li, J.; Wang, Y.; Huang, L.; He, F.; Liang, C.; Li, M.; Han, R.; Jiang, Y.
10.1101/2024.12.29.630569 — genomics — Posted on 2024-12-30
175 Organ injury accelerates stem cell differentiation by modulating a fate-transducing lateral inhibition circuit
Sanders, E. N.; Sun, H.-T.; Tabatabaee, S.; Lang, C. F.; van Dijk, S. G.; Su, Y.-H.; Labott, A.; Idris, J.; Marchetti, M.; Xie, S.; O'Brien, L. E.
10.1101/2024.12.29.630675 — developmental biology — Posted on 2024-12-30
176 Modeling Diffusive Search by Non-Adaptive Sperm: Empirical and Computational Insights
Brisard, B. M.; Cashwell, K. D.; Stewart, S. M.; Harrison, L. M.; Charles, A. C.; Dennis, C. V.; Henslee, I. R.; Carrow, E. L.; Belcher, H. A.; Bhowmick, D.; Vos, P. W.; Majka, M.; Bier, M.; Hart, D. M.; Schmidt, C. A.
10.1101/2024.06.17.599386 — cell biology — Posted on 2024-12-30
177 Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models
Sokolova, D.; Addington Ghansah, S.; Puletti, F.; Georgiades, T.; De Schepper, S.; Zheng, Y.; Crowley, G.; Wu, L.; Rueda-Carrasco, J.; Koutsiouroumpa, A.; Muckett, P.; Freeman, O. J.; Khakh, B. S.; Hong, S.
10.1101/2024.08.31.606944 — neuroscience — Posted on 2024-12-30
178 Cisplatin reprogramming of protein phosphorylation
Qi, L.; Zhou, Y.; Hou, Y.; Luo, Q.; Xu, Y.; Liu, X.; Yu, W.; Xin, B.; Huang, Y.; Han, J.; Li, X.; Zhang, Y.; Jia, F.; Fang, T.; Wang, S.; Sadler, P.; Zhao, Y.; Wang, F.
10.1101/2024.02.28.582513 — cancer biology — Posted on 2024-12-30
188 Mapping the GALNT1 substrate landscape with versatile proteomics tools
Saei, A. A.; Lundstrom, S. L.; Lyu, H.; Gharibi, H.; Lu, W.; Fang, P.; Zhang, X.; Meng, Z.; Wang, J.; Gaetani, M.; Vegvari, A.; Gygi, S. P.; Zubarev, R. A.
10.1101/2022.08.24.505189 — biochemistry — Posted on 2024-12-30
189 Estimating gene conversion tract length and rate from PacBio HiFi data
Charmouh, A. P.; Porsborg, P. S.; Hansen, L. T.; Besenbacher, S.; Winge, S. B.; Almstrup, K.; Hobolth, A.; Bataillon, T.; Schierup, M. H.
10.1101/2024.07.05.601865 — genomics — Posted on 2024-12-30
195 Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data.
Dudzic, P.; Chomicz, D.; Bielska, W.; Jaszczyszyn, I.; Zielinski, M.; Janusz, B.; Wrobel, S.; Le Pannerer, M.-M.; Philips, A.; Ponraj, P.; Kumar, S.; Krawczyk, K.
10.1101/2024.12.20.629642 — immunology — Posted on 2024-12-30
196 Inter- and Intrahemispheric Sources of Vestibular Signals to V1
Bouvier, G.; Sanzeni, A.; Hamada, E.; Brunel, N.; Scanziani, M.
10.1101/2024.11.18.624137 — neuroscience — Posted on 2024-12-30
198 A statistical framework for quantifying the nuclear export rate of influenza viral mRNAs.
Miura, M.; Kiuchi, N.; Lau, S.-Y.; Mok, B. W.-Y.; Ushirogawa, H.; Naito, T.; Chen, H.; Saito, M.
10.1101/2023.04.07.536075 — systems biology — Posted on 2024-12-30
200 Multi-species analysis of inflammatory response elements reveals ancient and lineage-specific contributions of transposable elements to NF-κB binding
Wang, L.; Taylor, T.; Rathnakumar, K.; Khyzha, N.; Liang, M.; Alizada, A.; Campitelli, L.; Pour, S. E.; Patel, Z. M.; Antounians, L.; Tobias, I. C.; Hughes, T.; Roy, S.; Mitchell, J. A.; Fish, J. E.; Wilson, M. D.
10.1101/2022.10.25.513724 — genomics — Posted on 2024-12-30
201 A direct interaction between the RNA-binding proteins Staufen and Tm1-I/C regulates oskar mRNP composition and transport
Gaber, T.; Grabowski, J.; Simon, B.; Monecke, T.; Williams, T.; Roman, V.; Chao, J.; Hennig, J.; Ephrussi, A.; Niessing, D.; Heber, S.
10.1101/2024.12.18.629124 — molecular biology — Posted on 2024-12-30
211 Enzyme-independent functions of HDAC3 in the adult heart
Qian, S.; Zhang, C.; Li, W.; Song, S.; Lin, G.; Cheng, Z.; Zhou, W.; Yin, H.; Li, H.; Shen, H.-Y.; Sun, Z.
10.1101/2024.12.29.630635 — physiology — Posted on 2024-12-30
212 Characterizing Tyrosine Ring Flips in Proteins by 19F NMR
Lu, M.; Xu, G.; Wu, Q.; Liu, X.; Yang, M.; Jiang, L.; Yang, M.; Liu, M.; Li, C.
10.1101/2024.12.29.630691 — biochemistry — Posted on 2024-12-29
216 Muller's Ratchet and Gene Duplication
Freund, F.; Wirtz, J.; Zheng, Y.; Schaefer, Y.; Wiehe, T.
10.1101/2024.12.27.630357 — evolutionary biology — Posted on 2024-12-29
219 Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport
Wojcechowskyj, J. A.; Jong, R. M.; Mager, I.; Flach, B.; Munson, P. V.; Mukherjee, P.; Mertins, B.; Barcay, K. R.; Folliard, T.
10.1101/2024.12.29.630334 — immunology — Posted on 2024-12-29
221 Primary sensory neuron dysfunction underlying mechanical itch hypersensitivity in a Shank3 mouse model of autism
Huzard, D.; Marias, M.; Granat, c.; Oliva, G.; Soubeyre, V.; Grellier, G.; Negm, A.; Devaux, J.; Bourinet, E.; Francois, A.
10.1101/2024.12.29.630575 — neuroscience — Posted on 2024-12-29
222 Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
Huber, M. K.; Widener, A. E.; Cuaycal, A. E.; Smurlick, D.; Butterworth, E. A.; Lenchik, N. I.; Chen, J.; Beery, M.; Hiller, H.; Verney, E.; Kusmartseva, I.; Slak Rupnik, M.; Campbell-Thompson, M.; Gerling, I. C.; Atkinson, M. A.; Mathews, C. E.; Phelps, E. A.
10.1101/2024.12.29.630665 — physiology — Posted on 2024-12-29
223 Intrahepatic crystals from elevated dietary cholesterol are sufficient to stiffen the liver
Li, D.; Loneker, A. E.; Safraou, Y.; Ford, J.; Mihelc, E.; Levental, K. R.; Levental, I.; Sack, I.; Janmey, P. A.; Wells, R. G.
10.1101/2024.12.29.630682 — physiology — Posted on 2024-12-29
232 Motor unit mechanisms of speed control in mouse locomotion
Thomas, K.; Gibbs, R.; Marques, H.; Carey, M. R.; Sober, S. J.
10.1101/2024.12.29.628022 — neuroscience — Posted on 2024-12-29
234 Barcoding-inferred biodiversity of shallow-water Indo-Pacific demosponges
Erpenbeck, D.; Galitz, A.; Berumen, M. L.; Büttner, G.; Debitus, C.; Dirnberger, M.; Ekins, M.; Hall, K.; Namuth, L.; Petek, S.; Rahnamae, N.; Reddy, M. M.; Rettenberger, D.; Ries, S. R.; Schätzle, S.; Schönberg, C. H.; Setiawan, E.; van der Sprong, J.; Thomas, O. P.; Tirumalasetty, V.; de Voogd, N. J.; Voigt, O.; Hooper, J. N.; Wörheide, G.
10.1101/2024.12.29.630654 — zoology — Posted on 2024-12-29
237 Biophysical boundaries for dormancy release in sunflower achenes.
Arata, G. J.; Batlla, D.; Riveira-Rubin, M.; Demkura, P. V.; Mazzobre, M. F.; Rolandelli, G.; Buera, M. d. P.; Rodriguez, M. V.
10.1101/2024.12.28.630629 — plant biology — Posted on 2024-12-29
239 Enhanced Tumor Control and Hearing Loss Prevention Achieved with Combined Immune Checkpoint Inhibitor and Anti-VEGF Therapy in Vestibular Schwannoma Model
Lu, S.; Yin, Z.; Wu, L.; Sun, Y.; Chen, J.; Wu, L. M. N.; Oblinger, J. L.; Blake, D. C.; Landegger, L. D.; Seist, R.; Ho, W.; Xiu, B.; Jones, A. P.; Muzikansky, A.; Stankovic, K. M.; Plotkin, S.; Chang, L.-S.; Xu, L.
10.1101/2024.12.29.630658 — cancer biology — Posted on 2024-12-29
240 Direct and abscopal anti-tumor responses elicited by peripheral nerve schwannoma irradiation synergize with anti-PD1 treatment in vestibular schwannoma models
Yin, Z.; Lu, S.; Wu, L.; Sun, Y.; Blake, D. W.; Chen, J.; Landegger, L. D.; Ho, W.; Xiu, B.; Jones, A. P.; Muzikansky, A.; Shih, H. A.; Stankovic, K. M.; Plotkin, S. R.; Xu, L.
10.1101/2024.12.29.630655 — cancer biology — Posted on 2024-12-29
247 High Pathogenicity Avian Influenza Virus (HPAIV) H5N1 clade 2.3.4.4b recovered from a kelp gull (Larus dominicanus) in the South Shetland Islands, Antarctica
Ogrzewalska, M.; Pereira, E. C.; Vanstreels, R. E. T.; Campista, E.; Correa Junior, L.; Macedo, L.; Appolinario, L. R.; Brandao, M. L.; Vilela, R.; Degrave, W.; Motta, F.; Siqueira, M.; Resende, P. C.
10.1101/2024.12.29.630510 — molecular biology — Posted on 2024-12-29
252 The genetic architecture of cell-type-specific cis-regulation in maize
Marand, A. P.; Jiang, L.; Gomez-Cano, F. A.; Minow, M. A. A.; Zhang, X.; Mendieta, J. P.; Luo, Z.; Bang, S.; Yan, H.; Meyer, C.; Schlegel, L.; Johannes, F.; Schmitz, R. J.
10.1101/2024.08.17.608383 — genetics — Posted on 2024-12-29
257 Goliath clades and in vivo tracking of clonal dynamics show three phases of UV-induced skin carcinogenesis
Avdieiev, S.; Tordesillas, L.; Prieto, K.; Chavez Chiang, O.; Chen, Z.; Patel, N.; Cordero, S.; Simoes, L.; Chen, Y. A.; Andor, N.; Gatenby, R.; Flores, E.; Whelan, C. J.; Brown, J. S.; Tsai, K.
10.1101/2024.12.28.623235 — cancer biology — Posted on 2024-12-29
258 The 1001G+ project: A curated collection of Arabidopsis thaliana long-read genome assemblies to advance plant research
Alonso-Blanco, C. C.; Ashkenazy, H.; Baduel, P.; Bao, Z.; Becker, C.; Caillieux, E.; Colot, V.; Crosbie, D.; De Oliveira, L.; Fitz, J.; Fritschi, K.; Grigoreva, E.; Guo, Y.; Habring, A.; Henderson, I.; Hou, X.-H.; Hu, Y.; Igolkina, A.; Kang, M.; Kemen, E.; Kersey, P. J.; Kornienko, A.; Lian, Q.; Liu, H.; Liu, J.; Lucke, M.; Mayjonade, B.; Mercier, R.; Molla Morales, A.; Movilli, A.; Murray, K. D.; Naish, M.; Nordborg, M.; Rabanal, F. A.; Roux, F.; Schandry, N.; Schneeberger, K.; Schwab, R.; Shirsekar, G.; Sushko, S.; Tao, Y.; Teasdale, L.; Vorbrugg, S.; Weigel, D.; Xian, W.
10.1101/2024.12.23.629943 — genomics — Posted on 2024-12-29
260 Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum
Wei, L.; Cao, H.-Y.; Zou, R.; Du, M.; Zhang, Q.; Lu, D.; Xu, X.; Xu, Y.; Wang, W.; Chen, X.-L.; Zhang, Y.-Z.; Li, F.
10.1101/2024.09.04.611182 — biochemistry — Posted on 2024-12-29
261 GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density
Conery, M.; Pippin, J. A.; Wagley, Y.; Trang, K.; Pahl, M. C.; Villani, D. A.; Favazzo, L. J.; Ackert-Bicknell, C. L.; Zuscik, M. J.; Katsevich, E.; Wells, A. D.; Zemel, B. S.; Voight, B. F.; Hankenson, K. D.; Chesi, A.; Grant, S. F.
10.1101/2024.03.19.585778 — genomics — Posted on 2024-12-29
262 Evolution of mental traits linked to cultural development in modern humans and Neanderthals
Moriya, Y.; Fujito, N. T.; Terahara, M.; Takahata, N.; Satta, Y.; Teshima, K. M.; Hayakawa, T.
10.1101/2024.08.13.604521 — evolutionary biology — Posted on 2024-12-29
265 Epigenetic Disordering Drives Stemness, Senescence Escape and Tumor Heterogeneity
Magnani, E.; Macchi, F.; Randic, T.; Chen, C.; Madakashira, B. P.; Ranjan, S.; Eski, S. E.; Singh, S. P.; Sadler, K. C.
10.1101/2024.12.29.629346 — cancer biology — Posted on 2024-12-29
266 Evolutionary conserved reciprocal senescence and tumor suppressor signals limit lifetime cancer
Liu, L.; Davis, S.; Yusuff, S.; Strange, A.; Zhuang, Y.; Vaddi, P.; Flaherty, K.; Jara, K.; Kramer, J.; Archer, C.; Lee, S.; Gao, B.; van Bokhoven, A.; Wang, W.; Pine, S. R.; Nakamura, T.; Sabaawy, H. E.
10.1101/2024.12.28.630560 — cancer biology — Posted on 2024-12-29
267 Metabolic Switch in Endocrine Resistant Estrogen Receptor Positive Breast Cancer
Brechbuhl, H. M.; Han, A. L.; Vinod-Paul, K.; Nemkov, T.; Ramachandran, S.; Ward, A.; Jacobsen, B. M.; Hansen, K.; Sartorius, C. A.; D'Alessandro, A.; Kabos, P.
10.1101/2024.12.28.630631 — cancer biology — Posted on 2024-12-29
268 Development of a high-throughput 3D culture microfluidic platform for multi-parameter phenotypic and omics profiling of patient-derived organoids
Botrugno, O. A.; Bianchi, E.; Bruno, J. M.; Felici, C.; Gallo, G. F. M.; Sommella, E. M.; Merciai, F.; Caponigro, V.; Golino, V.; La Gioia, D.; De Stefano, P. D.; Giansanti, V.; Rossella, V.; Lazarevic, D.; Colombo, E.; Falletta, P.; Giovannoni, G.; Gatti, G.; Ratti, F.; Buonanno, S.; Pedica, F.; Tacchetti, C.; Zambrano, S.; Mazza, D.; Cittaro, D.; Campiglia, P.; Aldrighetti, L.; Tonon, G.; Dubini, G.
10.1101/2024.12.28.630600 — cancer biology — Posted on 2024-12-29
270 Finding Salient Multi-Omic Interactomes Relevant to Multiple Biomedical Outcomes using Graph Ensemble Neural Networks
Chan, J.; Becker, A.; Haque, S. J.; Fleming, J.; McElroy, J.; Meng, W.; Webb, A.; Kelly, R. S.; Celedon, J.; Clish, C. B.; Gerszten, R.; McGeachie, M.; Weiss, S. T.; Lasky-Su, J. A.; Chakravarti, A.; Mathe, E.; Machiraju, R.; Eicher, T. D.
10.1101/2024.12.28.630633 — bioinformatics — Posted on 2024-12-29
273 Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina
Yuan, Y.; Biswas, P.; Zemke, N.; Dang, K.; Wu, Y.; D Antonio, M.; Xie, Y.; Yang, Q.; Dong, K.; Lau, P. K.; Li, D.; Seng, C.; Bartosik, W.; Buchanan, J.; Lin, L.; Lancione, R.; Wang, K.; Lee, S.; Gibbs, Z.; Ecker, J.; Frazer, K.; Wang, T.; Preissl, S.; Wang, A.; Ayyagari, R.; Ren, B.
10.1101/2024.12.28.630634 — genomics — Posted on 2024-12-29
275 Habitat complexity defines global biological and societal landscapes
Cant, J.; Schiettekatte, N.; Madin, E. M. P.; Madin, J. S.; Dornelas, M.
10.1101/2024.12.28.630608 — ecology — Posted on 2024-12-29
277 Different hydrological conditions after permafrost thaw result in distinct microbial community compositions
Waqas, M.; Liebmann, P.; Vogel, C.; Varsadiya, M.; Wang, H.; Shibistova, O.; Novak, M.; Urich, T.; Guggenberger, G.; Barta, J.
10.1101/2024.12.28.630578 — ecology — Posted on 2024-12-29
279 Bovine Formative Embryonic Stem Cell Plasticity in Embryonic and Extraembryonic Differentiation
Su, Y.; Zhao, R.; Fang, Y.; Li, G.; Jin, L.; Liu, J.; Yang, Z.; Li, N.; Zhu, J.; Mishra, N.; Kaback, D.; Yee, S.-P.; Lei, C.; Duan, E.; Tian, X.; Tang, Y.
10.1101/2024.12.28.630627 — developmental biology — Posted on 2024-12-29
281 Pelagic ecosystem responses to changes in seawater conditions during the Middle Pleistocene Transition in the Eastern Mediterranean
Agiadi, K.; Vasiliev, I.; Vite, A.; Zarkogiannis, S.; Fuster-Alonso, A.; Mestre-Tomas, J.; Koskeridou, E.; Quillevere, F.
10.1101/2024.12.28.630586 — systems biology — Posted on 2024-12-29
284 Eliminating Aggressive Cancers via PROTAC-like Inducers of Ferroptosis
Oknin-Vaisman, A.; Panda, D.; Novak, R.; Bitman-Lotan, E.; Pahor, N.; Abu Ahmad, Y.; Kamnesky, G.; Diefenbacher, M. E.; Brik, A.; Orian, A.
10.1101/2024.12.28.630572 — cancer biology — Posted on 2024-12-29
285 The Arp2/3 complex maintains genome integrity and survival of epidermal Langerhans cells
Delgado, M.-G.; Burkhart, A.-K.; Villar, J.; Amadio, R.; Racz, V. S.; Sanseau, D.; De Silva, N.; Lacerda Mariano, L.; Bracchetti, G.; Shmakova, A.; Chipont, A.; San Roman, M.; Calmettes, V.; Alraies, Z.; Maurin, M.; Dauphin, A.; Guerin, C.; Ginhaux, F.; Manel, N.; Fachinetti, D.; Benvenuti, F.; Iden, S.; Lennon-Dumenil, A.-M.
10.1101/2024.12.27.630538 — cell biology — Posted on 2024-12-29
286 Negative feedback equalizes polarity sites in a multi-budding yeast
Crocker, A. W.; Petrucco, C. A.; Guan, K.; Wirshing, A. C. E.; Ekena, J. L.; Lew, D. J.; Elston, T. C.; Gladfelter, A. S.
10.1101/2024.12.28.630626 — cell biology — Posted on 2024-12-29
287 Plasticity of visual looming response reveals a dissociation of innate and learned components
Conway, P. B.; Autore, L.; Munoz Zamora, A.; Harel, A.; Tavallaei, A. A.; Winston, S. M.; Ortega-de San Luis, C.; O'Leary, J.; Brimble, M. A.; Vetere, G.; Ryan, T. J.
10.1101/2024.12.18.628938 — neuroscience — Posted on 2024-12-29
289 Migrastatic Therapy as a Potential Game-Changer inAdaptive Cancer Treatment
Schneider, K.; Spekking, L.; Azimi, S.; Peltanova, B.; Rosel, D.; Brown, J. S.; Gatenby, R.; Brabek, J.; Stankova, K.
10.1101/2024.12.28.630610 — cancer biology — Posted on 2024-12-28
293 The KDM6 histone demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells
Cribbs, A. P.; Hookway, E. S.; Yapp, C.; Che, K.-H.; Dunford, J. E.; Gutheridge, K.; Lari, F.; Wells, G.; Philpott, M.; Cain, P.; Brotherton, D.; Palmer, C.; Maret, W.; Fitzgibbons, J.; Christianson, J. C.; Oppermann, U.
10.1101/2024.12.28.630531 — cell biology — Posted on 2024-12-28
294 Towards community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii
Kelley, R.; Khavnekar, S.; Righetto, R. D.; Heebner, J.; Obr, M.; Zhang, X.; Chakraborty, S.; Tagiltsev, G.; Michael, A. K.; van Dorst, S.; Waltz, F.; McCafferty, C. L.; Lamm, L.; Zufferey, S.; Van der Stappen, P.; van den Hoek, H.; Wietrzynski, W.; Harar, P.; Wan, W.; Briggs, J. A. G.; Plitzko, J. M.; Engel, B. D.; Kotecha, A.
10.1101/2024.12.28.630444 — cell biology — Posted on 2024-12-28
295 Apolipoprotein-L1 G1 variant contributes to hydrocephalus but not to atherosclerosis in apolipoprotein-E knock-out mice
Yoshida, T.; Yang, Z.-H.; Ashida, S.; Yu, Z.-X.; Shrivastav, S.; Rojulpote, K. V.; Bahar, P.; Nguyen, D.; Springer, D. A.; Munasinghe, J.; Starost, M. F.; Hoffmann, V. J.; Rosenberg, A. Z.; Bielekova, B.; Wen, H.; Remaley, A. T.; Kopp, J. B.
10.1101/2024.12.28.630625 — molecular biology — Posted on 2024-12-28
296 Benchmarking of Chromatin Immunoprecipitation (ChIP-Seq) methods in the Pacific oyster Magallana gigas
Dellong, A.; Fallet, M.; Stenger, P.-L.; Chaparro, C.; Vidal-Dupiol, J.; Clement, J. A. J.; Cosseau, C.; Grunau, C.
10.1101/2024.12.28.630603 — molecular biology — Posted on 2024-12-28
298 Biofilm formation on glycated collagen modulates Streptococcus mutans bacterial extracellular vesicle production and cargo
Leiva-Sabadini, C.; Berrios, P.; Saavedra, P.; Carrasco-Rojas, J.; Gonzalez-Aramundiz, J. V.; Vera, M.; Tarifeno-Saldivia, E.; Schuh, C. M. A. P.; Aguayo, S.
10.1101/2024.12.28.630307 — microbiology — Posted on 2024-12-28
300 Construction of a drug sensitised Candida auris strain
Hassan, M.; Furner-Pardoe, J.; Chen, Y.; Mason, A. J.; Rahman, K. M.; Sutton, J. M.; Hind, C.; Panaretou, B.
10.1101/2024.12.28.630619 — microbiology — Posted on 2024-12-28
301 PSGL-1 excludes HIV Env from virion surface through spatial hindrance involving structural folding of the decameric repeats (DR)
Tiwari, S.; Delfing, B. M.; Han, Y.; Lockhart, C.; Haikerwal, A.; Waheed, A. A.; Freed, E. O.; Jafri, M. S.; Klimov, D.; Wu, Y.
10.1101/2024.12.28.630612 — microbiology — Posted on 2024-12-28
302 Stick together: Isolation and characterization of exopolysaccharide producing bacteria from degraded permafrost soils
Waqas, M.; Zelenkova, S.; Vogel, C.; Ruhmann, B.; Varsadiya, M.; Liebmann, P.; Wang, H.; Shibistova, O.; Urich, T.; Guggenberger, G.; Barta, J.
10.1101/2024.12.28.630587 — microbiology — Posted on 2024-12-28
303 Type 1 lymphocytes and interferon-γ accumulate in the thalamus and restrict seizure susceptibility after traumatic brain injury
Mroz, N. M.; Ciesielska, A.; Ewing-Crystal, N. A.; Dorman, L. C.; Han, R. T.; Barron, J. J.; Silva, N. J.; Molofsky, A. V.; Molofsky, A. B.; Paz, J. T.
10.1101/2024.12.28.630606 — immunology — Posted on 2024-12-28
304 Base edited "universal" donor CAR T cell strategies for acute myeloid leukaemia
Kadirkamanathan, R.; Georgiadis, C.; Kloos, A.; Etuk, A.; Preece, R.; Gough, O.; Schambach, A.; Sauer, M.; Heuser, M.; Qasim, W.
10.1101/2024.12.28.630573 — immunology — Posted on 2024-12-28
306 Spatially informed phenotyping by cyclic-in-situ-hybridization identifies novel fibroblast populations and their pathogenic niches in systemic sclerosis
Li, Y.-N.; Filla, T.; Gyoerfi, A.-H.; Liang, M.; Devakumar, V.; Micu, A.; Chai, H.; Bergmann, C.; Pecher, A.-C.; Henes, J.; Moinzadeh, P.; Krieg, T.; Kreuter, A.; Schett, G.; Homey, B.; Dietrich, S.; Distler, J. H. W.; Matei, A.-E.
10.1101/2024.12.28.630505 — immunology — Posted on 2024-12-28
307 Multifaceted B-cell response to transient HIV viraemia in elite controllers
Muir, L.; Suchanek, O.; Thomas, P.; Griffith, S. A.; Touizer, E.; Rees-Spear, C.; Yoshida, M.; Pinder, C. L.; Nikolic, M. Z.; Doores, K. J.; Van Gils, M.; Gupta, R. K.; Clatworthy, M. R.; McCoy, L. E.
10.1101/2024.12.28.630596 — immunology — Posted on 2024-12-28
310 Untangling structural molecular details of the endocytic adaptor protein CALM upon binding with phosphatidylinositol 4,5-bisphosphate-containing model membranes
Santamaria, A.; Pereira, D.; Pawar, N.; Kelly, B.; Carrascosa-Tejedor, J.; Sardo, M.; Mafra, L.; Fragneto, G.; Owen, D.; Marin-Montesinos, I.; Guzman, E.; Zaccai, N.; Maestro, A.
10.1101/2024.12.28.630489 — biophysics — Posted on 2024-12-28
311 Expandable, Functional Hepatocytes Derived from Primary Cells Enable Liver Therapeutics
Mallanna, S. K.; Karanth, S. S.; Marturano, J. E.; Kudva, A. K.; Lehmann, M.; Morse, J. K.; Jamiel, M.; Norman, T.; Wilson, C. G.; Munarin, F.; Broderick, D.; Van Buskirk, M.; Uddin, E.; Ret, M.; Steele, C. A.; Cheema, M. K.; Black, J.; Vanderploeg, E. J.; Chen, C. S.; Bhatia, S.; Rezania, A.; Lowery, T. J.; Cazanave, S. C.; Chhabra, A.
10.1101/2024.12.28.630269 — bioengineering — Posted on 2024-12-28
312 Chromosome end protection by RAP1-mediated inhibition of DNA-PK
Eickhoff, P.; Sonmez, C.; Fisher, C. E. L.; Inian, O.; Roumeliotis, T. I.; dello Stritto, A.; Mansfeld, J.; Choudhary, J. S.; Guettler, S.; Lottersberger, F. I.; Douglas, M. E.
10.1101/2024.12.28.630583 — biochemistry — Posted on 2024-12-28
313 Experimental evolution of gene essentiality in bacteria
Bao, L.; Zhu, Z.; Ismail, A.; Zhu, B.; Anandan, V.; Whiteley, M.; Kitten, T.; Xu, P.
10.1101/2024.07.16.600122 — evolutionary biology — Posted on 2024-12-28
319 Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths
Lindhout, F. W.; Szafranska, H. M.; Imaz-Rosshandler, I.; Guglielmi, L.; Moarefian, M.; Voitiuk, K.; Zernicka-Glover, N. K.; Lloyd-Davies Sanchez, D. J.; Minnick, J.; Teodorescu, M.; Lancaster, M. A.
10.1101/2024.12.28.630576 — developmental biology — Posted on 2024-12-28
320 Human precentral gyrus neurons link speech sequences from listening to speaking
Xu, D.; Chung, J. E.; Greicius, Q. R.; Metzger, S. L.; Zhang, Y.; Leonard, M. K.; Chang, E. F.
10.1101/2024.12.27.630563 — neuroscience — Posted on 2024-12-28
322 Functional expression and sex dimorphism of the T-type Cav3.2 Calcium Channel in human DRG Neurons
chemin, j.; soubeyre, v.; Shiers, S.; Francois, A.; poulen, g.; Lonjon, N.; Vachiery, F.; Bauchet, L.; Mery, P.-F.; Price, T. J.; Bourinet, E.
10.1101/2024.12.27.630548 — neuroscience — Posted on 2024-12-28
323 Hampered AMPK-ULK1 cascade in Alzheimer disease (AD) instigates mitochondria dysfunctions and AD-related alterations that are alleviated by metformin
Mary, A.; Barale, S.; Eysert, F.; Valverde, A.; Lacas-Gervais, S.; Bauer, C.; Eddarkaou, S.; Buee, L.; Buee-Scherrer, V.; Checler, F.; Chami, M.
10.1101/2024.12.28.630598 — neuroscience — Posted on 2024-12-28
324 Volitional stopping is preceded by a transient beta oscillation
Doutel Figueira, J. F.; Ojala, R. A.; Vasilev, D.; De Miguel, A.; Jeay-Bizot, L. K.; Iwai, R.; Raposo, I.; Safaei, N.; de Sardenberg Schmid, L.; Maoz, U.; Watanabe, M.; Totah, N. K.
10.1101/2024.12.28.630599 — neuroscience — Posted on 2024-12-28
325 Interaction between native and prosthetic visual responses in optogenetic visual restoration
Carpentiero, E.; Hughes, S.; Rodgers, J.; Xhaferri, N.; Biswas, S.; Gilhooley, M. J.; Hankins, M. W.; Lindner, M.
10.1101/2024.12.28.630611 — neuroscience — Posted on 2024-12-28
326 Decoding primitive endoderm - epiblast interactions using mouse ICM embryoids
Tan, B.; Schaffers, O.; Merzouk, S.; Bindels, E.; Huylebroeck, D.; Gribnau, J.; Dupont, C.
10.1101/2024.12.28.630545 — developmental biology — Posted on 2024-12-28
327 Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation
Sutcliffe, M. A.; Wingett, S. W.; Morris, C. A.; Wong, E.; Schoenfelder, S.; Lancaster, M. A.
10.1101/2024.12.27.630149 — developmental biology — Posted on 2024-12-28
328 Cell Morphology accurately predicts the nuclear shape of adherent cells
Lawton, S.; Danzman, R. A.; Spagnuolo, R.; Stephan, S.; Graul, S.; Wiggan, O.; Ghosh, S.; Prasad, A.
10.1101/2024.12.28.630588 — cell biology — Posted on 2024-12-28
329 Keratin 16 spatially inhibits type I interferon responses in stressed skin
Cohen, E.; Xu, Y.; Orosco, A.; Wang, D.; Johnson, C. N.; Steen, K.; Sarkar, M. K.; Ozlu, N.; Tsoi, L. C.; Gudsonsson, J. E.; Parent, C.; Coulombe, P. A.
10.1101/2024.12.27.630544 — immunology — Posted on 2024-12-28
331 Investigating the consequences of the mating system for drug resistance evolution in C. elegans
Trubenova, B.; Hellinga, J.; Krücken, J.; von Samson-Himmelstjerna, G.; Schulenburg, H.; Regoes, R. R.
10.1101/2024.11.07.620884 — evolutionary biology — Posted on 2024-12-28
335 Mixed DAMP/MAMP oligosaccharides promote both growth and defense against fungal pathogens of cucumber
Pring, S.; Kato, H.; Taniuchi, K.; Camagna, M.; Saito, M.; Tanaka, A.; Merritt, B. A.; Arguello-Miranda, O.; Sato, I.; Chiba, S.; Takemoto, D.
10.1101/2024.12.27.630494 — plant biology — Posted on 2024-12-28
336 Green Synthesized Magnolia alba Silver Nanoparticles Kill Pathogens, Inhibit Cancer, and Display Antioxidant and Photocatalytic Properties
De Mel, S.; Gruenler, J.; Khoury, L.; Heynes, A.; Frazekas, J.; Damaske, K.; Galbadage, T.; Gunasekera, R. S.; Anderson, R. S.
10.1101/2024.12.27.630567 — bioengineering — Posted on 2024-12-28
337 miR-126 modulates neural progenitor cell development
Bastiaans, J.; Glendinning, M. D.; de Marco Garcia, N.; Stuhlmann, H.
10.1101/2024.12.27.630551 — cell biology — Posted on 2024-12-28
339 Effects of meglumine antimoniate and allopurinol treatment on the fecal microbiome profile in dogs with leishmaniosis
Marti-Carreras, J.; Carrasco, M.; Nogura-Julian, M.; Francino, O.; Oliveira Leal, R.; Ferrer, L.; Oliva, G.; Molina, J.; Roura, X.
10.1101/2024.12.27.630535 — molecular biology — Posted on 2024-12-28
340 Cross-regulation of amino acid synthesis and catabolic electron transfer in bacteria
Mogi, H.; Tomita, K.; Hirose, A.; Yoshino, E.; Kasai, T.; Kouzuma, A.; Watanabe, K.
10.1101/2024.12.27.630285 — microbiology — Posted on 2024-12-28
341 Absolute abundance unveils Basidiobolus as a cross-domain bridge indirectly bolstering gut microbiome homeostasis
Ghotbi, M.; Stajich, J. E.; Dallas, J. W.; Rurik, A.; Cummins, C.; Vargas-Gastelum, L.; Ghotbi, M.; Spatafora, J. W.; Kelly, K. H.; Alexander, N. R.; Moe, K. C.; Syring, K. C.; Shadmani, L.; Perez-Marron, J.; Walker, D.
10.1101/2024.12.27.630554 — microbiology — Posted on 2024-12-28
343 Pathological α-synuclein elicits granulovacuolar degeneration independent of tau
Dues, D.; Erb, M.; Kasen, A.; Vasta, N.; Williams, E.; Nguyen, A. P. T.; Henderson, M.; Moore, D. J.
10.1101/2024.12.27.630547 — neuroscience — Posted on 2024-12-28
344 Altered neuronal network activity and connectivity in human Down Syndrome excitatory cortical neurons
Peter, M.; Real, R.; Strano, A.; Robinson, H. P. C.; Smith, M. A.; Barnes, S. J.; de Paola, V.; Livesey, F. J.
10.1101/2024.12.27.630530 — neuroscience — Posted on 2024-12-28
347 Shaping Kale Morphology and Physiology Using Different LED Light Recipes
Scandola, S.; Grubb, L. E.; Castillo, B.; Iliscupidez, L.; Kennedy, C.; Boyce, N.; Talasila, M.; Uhrig, R. G.
10.1101/2024.10.10.617428 — plant biology — Posted on 2024-12-28
348 The RNA-binding protein HuR impairs adipose tissue anabolism in pancreatic cancer cachexia
Arneson-Wissink, P. C.; Pelz, K.; Worley, B.; Mendez, H.; Pham, P.; McCarthy, G.; Chitsazan, A.; Brody, J. R.; Grossberg, A.
10.1101/2024.12.27.630549 — cancer biology — Posted on 2024-12-28
349 Cellular cartography reveals mouse prostate organization and determinants of castration resistance
Cho, H.; Zhang, Y.; Tien, J. C.-Y.; Mannan, R.; Luo, J.; Narayanan, S. P.; Mahapatra, S.; Hu, J.; Shelley, G.; Cruz, G.; Shahine, M.; Wang, L.; Su, F.; Wang, R.; Cao, X.; Dhanasekaran, S. M.; Keller, E. T.; Pitchiaya, S.; Chinnaiyan, A. M.
10.1101/2024.12.27.630532 — cancer biology — Posted on 2024-12-28
354 Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Scholl, D.; Boyd, T.; Latham, A. P.; Salazar, A.; Khan, A.; Boeynaems, S.; Holehouse, A. S.; Lander, G. C.; Sali, A.; Park, D.; Deniz, A. A.; Lasker, K.
10.1101/2024.12.27.630454 — cell biology — Posted on 2024-12-28
355 Chemically-inducible CRISPR/Cas9 circuits for ultra-high dynamic range gene perturbation
Srinivasan, R.; Sun, T.; Sandles, A.; Wu, D.; Wang, L.; Heidersbach, A. J.; Ho, C.; Xie, S.; Ng, A. H.; Haley, B.
10.1101/2024.12.27.630546 — molecular biology — Posted on 2024-12-28
356 A new class of penicillin-binding protein inhibitors to address drug-resistant Neisseria gonorrhoeae
Uehara, T.; Zulli, A. L.; Miller, B.; Avery, L. M.; Boyd, S. A.; Chatwin, C. L.; Chu, G.-H.; Drager, A. S.; Edwards, M.; Emeigh Hart, S. G.; Myers, C. L.; Rongala, G.; Stevenson, A.; Uehara, K.; Yi, F.; Wang, B.; Liu, Z.; Wang, M.; Zhao, Z.; Zhou, X.; Zhao, H.; Tkavc, R.; Jerse, A. E.; Stratton, C. M.; Bala, S.; Davies, C.; Pevear, D. C.; Burns, C. J.; Daigle, D. M.; Condon, S. M.
10.1101/2024.12.27.630553 — microbiology — Posted on 2024-12-27
357 Adaptive-learning physics-aware light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics
Zhu, L.; Sun, J.; Yi, C.; Zhang, M.; Zhang, Y.; Li, D.; Fei, P.; Chen, L.; He, M.; Zhang, Y.; Zheng, C.; Chen, H.; Wu, S.; Huang, Y.
10.1101/2023.03.15.532876 — microbiology — Posted on 2024-12-28
358 Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer
Mattiuz, R.; Boumelha, J.; Hamon, P.; Le Berichel, J.; Vaidya, A.; Soong, B. Y.; Halasz, L.; Radkevich, E.; Kim, H. M.; Park, M. D.-Y.; Donne, R.; Troncoso, L.; D'Souza, D.; Kaiza, M. E.; MacFawn, I. P.; Belabed, M.; Mestrallet, G.; Humblin, E.; Merand, R.; Hennequin, C.; Ioannou, G.; Ozbey, S.; Figueiredo, I.; Hegde, S.; Tepper, A.; Merarda, H.; Nemeth, E.; Goldstein, S.; Reid, A. M.; Noureddine, M.; Tabachnikova, A.; Ahmed, J.; Polydorides, A. D.; Bhardwaj, N.; Lujambio, A.; Chen, Z.; Gonzalez Kozlova, E.; Kim-Schulze, S.; Brody, J. D.; Schotsaert, M.; Moussion, C.; Gnjatic, S.; Sautes-Fridm
10.1101/2024.12.27.628014 — immunology — Posted on 2024-12-27
359 TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination
Halford, J.; Senatore, A. J.; Berryman, S.; Munoz, A.; Semidey, D.; Doan, R. A.; Coombs, A. M.; Noimany, B.; Emberley, K.; Emery, B.; Monk, K.; Murthy, S. E.
10.1101/2024.12.27.630433 — neuroscience — Posted on 2024-12-27
360 SLC35A2 loss of function variants affect glycomic signatures, neuronal fate, and network dynamics
Dulcie, L.; Sosicka, P.; Williams, D.; Bowyer, M.; Ressler, A.; Kohort, S.; Muron, S.; Crino, P.; Freeze, H.; Boland, M.; Heinzen, E.
10.1101/2024.12.27.630524 — neuroscience — Posted on 2024-12-27
361 Long-term, cell type-specific effects of prenatal stress on dorsal striatum and relevant behaviors in mice
Evans, M. M.; Hing, B. W. Q.; Weber, M. A.; Maurer, S. V.; Baig, A. I.; Kim, G. S.; Anema, S. L.; Ellerbroek, R. M.; Sivakumar, K.; Michaelson, J. J.; Narayanan, N. S.; Stevens, H. E.
10.1101/2024.12.27.627207 — neuroscience — Posted on 2024-12-27
363 A Blueprint of Sex-Specific Neuronal Regulation in the C. elegans Nervous System at Single-Cell Resolution
Haque, R.; Setty, H.; Lorenzo, R.; Stelzer, G.; Rotkopf, R.; Salzberg, Y.; Kumar, S.; Goldman, G.; Nir Halber, S.; Schneidman, E.; Leifer, A. M.; Laurent, P.; Oren-Suissa, M.
10.1101/2024.12.27.630541 — neuroscience — Posted on 2024-12-27
364 Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity
Bhambri, A.; Thai, P.; Wei, S.; Bae, H.-G.; Barbosa, D.; Sharma, T.; Yu, Z.; Xing, C.; Kim, J.-H.; Yu, G.; Sun, L.
10.1101/2024.12.27.630559 — neuroscience — Posted on 2024-12-27
367 MUTE drives asymmetric divisions to form stomatal subsidiary cells in Crassulaceae succulents
Cheng, X.; Lindner, H.; Hoffmann, L.; Gomes Filho, A. A. P.; Ruiz Duarte, P.; Boxall, S. F.; Gündogmus, Y. B.; Pritchard, J. H.; Haldenby, S.; Gemmell, M.; Darby, A.; Läderach, M.; Hartwell, J.; Raissig, M. T.
10.1101/2024.12.27.630159 — plant biology — Posted on 2024-12-27
368 Targeting endothelial ERG to mitigate vascular regression and neuronal ischemia in retinopathies
Ma, E.; Schafer, C. M.; Xie, J.; Rudenko, Y.; Knapp, J. T.; Randi, A. M.; Birdsey, G. M.; Griffin, C. T.
10.1101/2024.12.27.630529 — pathology — Posted on 2024-12-27
370 Small Molecule Modulators of Beta-arrestins
Kahsai, A. W.; Pakharukova, N.; Kwon, H. Y.; Shah, K. S.; Liang-Lin, J. G.; del Real, C. T.; Shim, P. J.; Lee, M. A.; Ngo, V. A.; Shreiber, B. N.; Liu, S.; Schwalb, A. M.; Espinoza, E. F.; Thomas, B. N.; Kunzle, C. A.; Smith, J. S.; Wang, J.; Kim, J.; Zhang, X.; Rockman, H. A.; Thomsen, A. R. B.; Rein, L. A. M.; Shi, L.; Ahn, S.; Masoudi, A.; Lefkowitz, R. J.
10.1101/2024.12.27.630464 — biochemistry — Posted on 2024-12-27
374 Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy
Ohno, H.; Nishimura, T.; Kainoh, K.; Ohashi, Y.; Onodera, N.; Kano, M.; Sari, L. N.; Masuda, M.; Tamura, Y.; Hayashi, Y.; Yamamoto, Y.; Takahashi, S.-I.; Mishima, Y.; Yoneyama, Y.; Takeuchi, Y.; Sekiya, M.; Matsuzaka, T.; Miyamoto, T.; Shimano, H.
10.1101/2024.03.01.582671 — cell biology — Posted on 2024-12-27
376 The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems
Wang, X.; Ruan, Y.; Zhang, L.; Chen, X.; Shi, Z.; Wang, H.; Chen, B.; Tracy, M. E.; Huang, L.; Wu, C.-I.; Wen, H.
10.1101/2023.06.14.545040 — evolutionary biology — Posted on 2024-12-27
379 Vascular endothelial growth factor-D improves lung vascular integrity during acute lung injury
Yuan, Y.; Sharma, L.; Tang, W.; Yoon, Y.; kirk, S.; Raredon, M. S. B.; Ahangari, F.; Khoury, J.; Qian, H.; Luan, Y.; Yuan, Q.; Chen, L.; Ke, Y.; Birukov, K.; Simons, M.; Wu, D.; Niklason, L. E.; Kaminski, N.
10.1101/2024.12.16.628787 — molecular biology — Posted on 2024-12-27
380 Longitudinal prevalence and co-carriage of pathogens associated with nursing home acquired pneumonia in three long-term care facilities
Whealy, R. N.; Roberts, A.; Furstenau, T. N.; Timm, S.; Maltinsky, S.; Wells, S.; Drake, K.; Ramirez, K.; Bolduc, C.; Ross, A.; Pearson, T.; Fofanov, V. Y.
10.1101/2024.12.19.629505 — microbiology — Posted on 2024-12-27
384 Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency
Tiwari, V.; Jin, B.; Sun, O.; Lopez Gonzalez, E. D. J.; Chen, M.-H.; Wu, X.; Shah, H.; Zhang, A.; Herman, M. A.; Spracklen, C. N.; Goodman, R. P.; Brenner, C.
10.1101/2024.12.27.630525 — molecular biology — Posted on 2024-12-27
388 Combinations of genomic alterations and immune microenvironmental features associate with patient survival in multiple cancer types
Bayati, M.; Klein, Z. P.; Bahcheli, A. T.; Slobodyanyuk, M.; To, J.; Cheng, K. C.; Mishra, J.; Pellegrina, D.; Guevara-Hoyer, K.; McIntosh, C.; Bhat, M.; Reimand, J.
10.1101/2024.12.27.630504 — cancer biology — Posted on 2024-12-27
396 Biochemical state in tissue can be detected through ultrasound signal
Ito, K.; Iijima, Y.; Misumi, T.; Hayase, G.; Tamura, K.; Ikushima, K.; Yoshino, D.
10.1101/2024.12.27.630453 — bioengineering — Posted on 2024-12-27
397 Conditional fusogenic lipid nanocarriers for cytosolic delivery of macromolecular therapeutics
Zhong, Q.; Tan, E. K. W.; Shyamal, A.; Ngambenjawong, C.; Parisi, T.; Ko, H.; Flemming, H.; Jacks, T.; Bhatia, S.
10.1101/2024.12.27.630514 — bioengineering — Posted on 2024-12-27
400 Phenolic compounds in Medicago truncatula roots are under the influence of Agrobacterium fabrum through its species specific-genes regions
Padilla, R.; Vial, L.; Dechevre, F.; Nguyen, T. H. T.; Gaillard, V.; Meiffren, G.; Comte, G.; Nesme, X.; Lavire, C.; Kerzaon, I.
10.1101/2024.12.27.630484 — ecology — Posted on 2024-12-27
401 Association Between Oral Microbiota and Close-Range Proximity in a Primary School
Dall'Amico, L.; Bai, X.; Weltzien, S. M.; Rayner, S.; Paolotti, D.; Budin Ljosne, I. S.; Matussek, A.; Furberg, A.-S.; Cattuto, C.; Sivert Nielsen, C.
10.1101/2024.12.27.628096 — microbiology — Posted on 2024-12-27
403 Truncated TrkB: The predominant TrkB Isoform in Nociceptors
Ruparel, J.; Chang, F.-M.; Tran, M.; Alfaro, J.; Ibrahim, T.; Wu, P.; Ruparel, S.
10.1101/2024.12.27.630513 — neuroscience — Posted on 2024-12-27
405 An Independent Coding Scheme for Distance versus Position in the Hippocampus
Nordlund, M.; Levernier, N.; Trippa, M.; Bourboulou, R.; Marti, G.; Monasson, R.; Rouault, H.; Epsztein, J.; Koenig-Gambini, J.
10.1101/2024.12.27.629676 — neuroscience — Posted on 2024-12-27
411 Network vulnerability of cattle movement in Minas Gerais, Brazil, from 2013 to 2022
Costa, A. C. T. R. B.; Savini, L.; de Oliveira, L. F.; Lage, A. P.; Dorneles, E. M. S.; Candeloro, L.
10.1101/2024.12.27.630473 — bioinformatics — Posted on 2024-12-27
416 Open-source cell culture automation system with integrated cell counting for passaging microplate cultures
Courville, G.; Vaid, S.; Toruno, A.; Lebel, P.; Cabrera, J.; Raghavan, P.; Jacobsen, A.; Bell, G. R.; Leonetti, M. D.; Gomez-Sjöberg, R.
10.1101/2024.12.27.629034 — bioengineering — Posted on 2024-12-27
418 Cataloguing the postnatal small intestinal transcriptome during the first postnatal month
Oliveria, L. F. S.; Khetani, R. S.; Wu, Y.-S.; Dasuri, V. S.; Harrington, A. W.; Olaloye, O.; Goldsmith, J. D.; Breault, D. T.; Konnikova, L.; Ho Sui, S. J.; O'Connell, A. E.
10.1101/2024.09.25.612672 — developmental biology — Posted on 2024-12-27
420 CRISPR-Cas supervises diverse anti-phage defense systems
Li, M.; shu, x.; Wang, R.; Cheng, F.; Li, Z.; Wu, A.; Xue, Q.; Liu, C.; Cao, X.; Feng, Y.
10.1101/2024.12.27.630466 — microbiology — Posted on 2024-12-27
421 Enolase-1 is essential for neutrophil recruitment during acute inflammation
Lu, H.-Y.; Huang, P.-H.; Lee, T.-W.; Chang, H.-W.; Chen, N.-Y.; Zhuang, Y.-J.; Yuan, T.-T.; Chen, C.-J.
10.1101/2024.12.26.630451 — immunology — Posted on 2024-12-27
424 Reshaping epigenomic landscapes in facilitating the speciation of bread wheat
Zhang, Z.; Lin, X.; Yue, J.; Xu, Y.; Miao, L.; Tang, W.; Guo, W.; Xiao, J.
10.1101/2024.12.26.630455 — plant biology — Posted on 2024-12-27
425 A compendium of nonredundant short Polymerase III promoters for CRISPR applications
Deguchi, M.; Sinclair, K. M.; Patel, A.; Coile, M.; Ortega, M. A.; Bewg, W. P.; Tsai, C.-J.
10.1101/2024.12.25.630128 — plant biology — Posted on 2024-12-27
426 Maize TIR-only Proteins ZmTIR1 and ZmTIR2, but not ZmTIR3 Confer Auto-active Hypersensitive Response Likely by Forming Condensation
Kang, Z.-X.; Ge, Q.-D.; Zhang, M.-L.; Tang, C.-X.; Yang, M.; Liu, S.; Dai, Y.-C.; Zhang, H.; Zang, K.; Li, S.; Wang, G.-F.
10.1101/2024.12.26.630462 — plant biology — Posted on 2024-12-27
433 Boltz-1: Democratizing Biomolecular Interaction Modeling
Wohlwend, J.; Corso, G.; Passaro, S.; Reveiz, M.; Leidal, K.; Swiderski, W.; Portnoi, T.; Chinn, I.; Silterra, J.; Jaakkola, T.; Barzilay, R.
10.1101/2024.11.19.624167 — biophysics — Posted on 2024-12-27
434 Scalable ultra-high-throughput single-cell chromatin and RNA sequencing reveals gene regulatory dynamics linking macrophage polarization to autoimmune disease
Lobato-Moreno, S.; Yildiz, U.; Claringbould, A.; Servaas, N. H.; Vlachou, E. P.; Arnold, C.; Bauersachs, H. G.; Campos-Fornes, V.; Prummel, K. D.; Noh, K. M.; Marttinen, M.; Zaugg, J. B.
10.1101/2023.12.26.573253 — genomics — Posted on 2024-12-27
438 Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution
Merino-Salomon, A.; Schneider, J.; Babl, L.; Krohn, J.-H.; Sobrinos-Sanguino, M.; Schäfer, T.; Luque-Ortega, J. R.; Alfonso, C.; Jimenez, M.; Jasnin, M.; Schwille, P.; Rivas, G.
10.1101/2023.01.12.523557 — biochemistry — Posted on 2024-12-27
441 MethylQUEEN: A Methylation Encoded DNA Foundation Model
Li, M.; Gu, R.; Fan, S.; Fan, Y.; He, B.; Yang, J.; Chen, Y.; Xin, M.; Wen, H.; Yi, C.
10.1101/2024.12.26.630389 — genomics — Posted on 2024-12-27
442 Mimetic butterfly wings through mimetic butterfly eyes
Dang, A.; Bernard, G. D.; Yuan, F.; Macias-Munoz, A.; Hill, R. I.; Lawrence, J. P.; Olguin, A. R. G.; Luis-Martinez, A.; Mullen, S. P.; Llorente-Bousquets, J.; Briscoe, A. D.
10.1101/2023.10.05.561098 — evolutionary biology — Posted on 2024-12-27
444 How Occam's razor guides human decision-making
Piasini, E.; Liu, S.; Chaudhari, P.; Balasubramanian, V.; Gold, J. I.
10.1101/2023.01.10.523479 — neuroscience — Posted on 2024-12-27
445 microGalaxy: A gateway to tools, workflows, and training for reproducible and FAIR analysis of microbial data
Nasr, E.; Amato, P.; Bhardwaj, A.; Blankenberg, D.; Brites, D.; Cumbo, F.; Do, K.; Ferrari, E.; Griffin, T. J.; Gruening, B.; Hiltemann, S.; Jagtap, P.; Mehta, S.; Metris, K. L.; Momin, S.; Oba, A.; Pavloudi, C.; Pechlivanis, N.; Peguilhan, R.; Psomopoulos, F.; Rosic, N.; Schatz, M. C.; Schiml, V. C.; Siguret, C.; Soranzo, N.; Stubbs, A.; Van Heusden, P.; Vohra, M.; microGalaxy Community, ; Zierep, P.; Batut, B.
10.1101/2024.12.23.629682 — bioinformatics — Posted on 2024-12-27
452 Priming versus propagating: distinct immune effects of an alpha- versus beta-particle emitting radiopharmaceutical when combined with immune checkpoint inhibition
Kerr, C. P.; Jin, W. J.; Liu, P.; Grudzinski, J. J.; de Aguiar Ferreira, C.; Comas Rojas, H.; Onate, A. J.; Kwon, O.; Hyun, M.; Bio Idrissou, M.; Welch Schwartz, R.; Vera, J. M.; Clark, P. A.; Takashima, M.; Erbe, A. K.; Shea, A. G.; Powers, M.; Pinchuk, A. N.; Massey, C. F.; Choi, C.; Hernandez, R. T.; Bednarz, B. P.; Ong, I. M.; Weichert, J. P.; Morris, Z. S.
10.1101/2024.12.26.630430 — cancer biology — Posted on 2024-12-27
453 IL-1β-driven NF-κB transcription of ACE2 as a Mechanism of Macrophage Infection by SARS-CoV-2
Lee, C.; Khan, R.; Mantsounga, C. S.; Sharma, S.; Pierce, J.; Amelotte, E.; Butler, C. A.; Farinha, A.; Parry, C.; Caballero, O.; Morrison, J. A.; Uppuluri, S.; Whyte, J. J.; Kennedy, J. L.; Zhang, X.; Choudhary, G.; Olson, R. M.; Morrison, A. R.
10.1101/2024.12.24.630260 — immunology — Posted on 2024-12-26
454 A practical DNA data storage using expanded alphabet introducing 5-methylcytosine
Liu, D.; Xu, D.; Shi, L.; Zhang, J.; Bi, K.; Luo, B.; Liu, C.; Li, Y.; Fan, G.; Wang, W.; Ping, Z.
10.1101/2024.12.26.630439 — synthetic biology — Posted on 2024-12-26
457 Population genomics reveals an ancient origin of heartworms in canids
Power, R. I.; Abdullah, S.; Walden, H. S.; Verocai, G. G.; Sanders, T. L.; Luksovsky, J. L.; Moorhead, A. R.; Dzimianski, M. T.; Foster, J. M.; Michalski, M. L. L.; Rojas, A.; Chacon, S. C.; Deak, G.; Mihalca, A. D.; Danesi, P.; Papadopoulos, E.; Taweethavonsawat, P.; Thi Buip, D.; Do Ngoc, A.; Sharma, R. S. K.; Ho, S. Y. W.; Doyle, S. R.; Slapeta, J.
10.1101/2024.12.26.630432 — evolutionary biology — Posted on 2024-12-26
458 Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod
Panebianco, C. J.; Essaidi, M.; Barnes, E.; Williams, A.; Vancikova, K.; Labberte, M. C.; Brama, P.; Nowlan, N. C.; Boerckel, J. D.
10.1101/2024.12.26.630423 — developmental biology — Posted on 2024-12-26
459 Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cells
Roy, G.; Ordonez, A.; Binns, D. D.; Rodriguez-dos-Santos, K.; Kwakye, M. B.; King, G. C.; Mukherjee, N.; Templin, A. T.; Tan, Z.-y.; Richardson, T. I.; Doud, E. H.; Mosley, A. L.; Emfinger, C. H.; Attie, A. D.; Keller, M. P.; Johnson, T. S.; Kalwat, M. A.
10.1101/2024.12.26.629558 — cell biology — Posted on 2024-12-26
461 Lysosomal reduced thiols are essential for mouse embryonic development
Adelmann, C. H.; Venkatachalam, A.; Huang, L.; Liu, M.; Germana, S.; Sabatini, D. M.; Fisher, D. E.
10.1101/2024.12.26.630348 — cell biology — Posted on 2024-12-26
462 Tertiary and quaternary structure remodeling by occupancy of the substrate binding pocket in a large glutamate dehydrogenase
Lazaro, M.; Chamorro, N.; Lopez-Alonso, J. P.; Charro, D.; Rasia, R. M.; Jimenez-Oses, G.; Valle, M.; Lisa, M.-N.
10.1101/2024.12.26.630402 — molecular biology — Posted on 2024-12-26
463 Inhibition of Mitochondrial Fission Protein Drp1 Ameliorates Myopathy in the D2-mdx Model of Duchenne Muscular Dystrophy
Rosen, H. G.; Berger, N.; Hodge, S. H.; Fujishiro, A.; Lourie, J.; Kapadia, V.; Linden, M. A.; Jee, E.; Kim, J.; Kim, Y.; Zou, K.
10.1101/2024.12.26.628172 — molecular biology — Posted on 2024-12-26
464 CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma
Chadourne, M.; Griffith, C.; Xu, X.; Brennan, E.; Vera, O.; Mecozzi, N.; Wang, K.; Jaeger, A. M.; Karreth, F. A.
10.1101/2024.12.26.630428 — molecular biology — Posted on 2024-12-26
466 Differentiating BOLD and non-BOLD signals in fMRI time series using cross-cortical depth delay patterns
Chen, J. E.; Blazejewska, A. I.; Fan, J.; Fultz, N. E.; Rosen, B. R.; Lewis, L. D.; Polimeni, J. R.
10.1101/2024.12.26.628516 — neuroscience — Posted on 2024-12-26
468 PrecisionTrack: Reliable Tracking of Large Groups of Animals Interacting in Complex Environments Over Extended Periods
Coulombe, V.; Roussel, D.-A.; Monfared, M. S.; Leboulleux, Q.; Peralta, M. R.; Aghel, K.; Gosselin, B.; Labonte, B.
10.1101/2024.12.26.630112 — neuroscience — Posted on 2024-12-26
470 Estrogens increase cancer cell efferocytosis to establish an immunosuppressive tumor microenvironment
Chakraborty, B.; Chakraborty, P.; Brown, M. C.; Crowder, D.; Goyal, A.; Safi, R.; Artham, S.; Kirkland, M.; Racioppi, A.; Juras, P.; Mukherjee, D.; Lim, F.; Byemerwa, J.; Gunn, K.; Floyd, S. R.; Beasley, G.; Wardell, S.; Chang, C.-Y.; McDonnell, D. P.
10.1101/2024.12.26.630419 — cancer biology — Posted on 2024-12-26
471 Targeting primary and metastatic ovarian cancer with a peptide derived from the human NAF-1/CISD2 protein
Neumann, E.; Sohn, Y. S.; Karmi, O.; Darash Yahana, M.; Cardenas, A. E.; Pikarsky, E.; Elber, R.; Friedler, A.; Mittler, R.; Nechushtai, R.
10.1101/2024.12.26.630413 — cancer biology — Posted on 2024-12-26
472 The Role of Electron Spin, Chirality, and Charge Dynamics in Promoting thePersistence of Nascent Nucleic Acid-Peptide Complexes
Vyas, P.; Santra, K.; Preeyanka, N.; Gupta, A.; Weil-Ktorza, O.; Zhu, Q.; Metanis, N.; Fransson, J.; Longo, L. M.; Naaman, R.
10.1101/2023.11.16.567399 — biophysics — Posted on 2024-12-26
474 Epithelium Stratifies via Nucleation and Growth Induced by Foam-Geometric Instability
Fukamachi, S.; Datta, R.; Wuergezhen, D.; Ichikawa, T.; Yagasaki, R.; Horiguchi, S. A.; Leeaw, P.; Omachi, K.; Sada, A.; Imayoshi, I.; Kajiwara, K.; Hiraiwa, T.; Fukuma, T.; Fujiwara, H.; Okuda, S.
10.1101/2024.12.26.630435 — biophysics — Posted on 2024-12-26
476 ECloudGen: Leveraging Electron Clouds as a Latent Variable to Scale Up Structure-based Molecular Design
Zhang, O.; Jin, J.; Wu, Z.; Zhang, J.; Yuan, P.; Lin, H.; Zhong, H.; Zhang, X.; Hua, C.; Zhang, Z.; Zhao, W.; Ying, K.; Huang, Y.; Yu, Y.; Zhao, H.; Kang, Y.; Pan, P.; Wang, J.; Guo, D.; Zheng, S.; Hsieh, C.-Y.; Hou, T.
10.1101/2024.06.03.597263 — bioinformatics — Posted on 2024-12-26
479 Extended Plasmonic Nanostructures Templated by Tobacco Mosaic Virus Coat Protein
Abu-Baker, I.; Al-Feghali, A.; Zolfaghar, E.; Velpula, G.; Biela, A.; De Feyter, S.; Heddle, J. G.; Cosa, G.; Blum, A. S.
10.1101/2024.12.26.630424 — biochemistry — Posted on 2024-12-26
482 mRNA-1273 vaccines adapted to JN.1 or KP.2 elicit cross-neutralizing responses against the JN.1 sublineages of SARS-CoV-2 in mice
Lee, D. W.; Nasir, A.; Elbashir, S.; Jani, H.; Speidel, T.; Gorrie, A.; Montes Berrueta, D.; Martin, P.; Tan, S.; Hou, Y. J.; Hardcastle, K.; Edwards, D.; Wu, K.; Carfi, A.; Budigi, Y.
10.1101/2024.12.24.629478 — immunology — Posted on 2024-12-26
484 A novel phylogenomics pipeline reveals complex pattern of reticulate evolution in Cucurbitales
Ortiz, E. M.; Hoewener, A.; Shigita, G.; Raza, M.; Maurin, O.; Zuntini, A.; Forest, F.; Baker, W. J.; Schaefer, H.
10.1101/2023.10.27.564367 — bioinformatics — Posted on 2024-12-26
489 Biophysical Simulation Enables Multi-Scale Segmentation and Atlas Mapping for Top-Down Spatial Omics of the Nervous System
Mohammed Ali, L. K.; Yim, A. K. Y.; Gerbi, E. B.; Nguyen, T.; Tu, N. K.; Ikede, F. P.; Sampaleanu, R.; Grigore, D.; Waligorski, J. E.; Kremitzki, C. L.; Yuan, L.; Dong, W.; Mitra, R. D.; Milbrandt, J. D.; Buchser, W. J.
10.1101/2024.08.02.605366 — neuroscience — Posted on 2024-12-26
493 An Expanded Registry of Candidate cis-Regulatory Elements for Studying Transcriptional Regulation
Moore, J. E.; Pratt, H. E.; Fan, K.; Phalke, N.; Fisher, J.; Elhajjajy, S. I.; Andrews, G.; Gao, M.; Shedd, N.; Fu, Y.; Lacadie, M. C.; Meza, J.; Ganna, M.; Choudhury, E.; Swofford, R.; Farrell, N. P.; Pampari, A.; Ramalingam, V.; Reese, F.; Borsari, B.; Yu, X.; Wattenberg, E. S.; Ruiz-Romero, M.; Razavi-Mohseni, M.; Xu, J.; Galeev, T.; Beer, M. A.; Guigo, R.; Gerstein, M.; Engreitz, J. M.; Ljungman, M.; Reddy, T. E.; Snyder, M.; Epstein, C. B.; Gaskell, E.; Bernstein, B. E.; Dickel, D. E.; Visel, A.; Pennacchio, L. A.; Mortazavi, A.; Kundaje, A.; Weng, Z.
10.1101/2024.12.26.629296 — genomics — Posted on 2024-12-26
494 Longer Interstimulus Intervals Enhance Efficacy of Automated Phase-Targeted Auditory Stimulation on Procedural Memory Consolidation
Kasties, V.; Meier, N.; Moser, N.-H.; Sassenburg, R.; Karlen, W.; Ferster, M. L.; Fattinger, S.; Maric, A.; Huber, R.
10.1101/2024.12.26.630252 — neuroscience — Posted on 2024-12-26
495 Ancestry-linked stromal variations impact breast epithelial cell invasion
Schmidtmann, M.; Elliott, V.; Clancy, J.; Nakshatri, H.; D'Souza-Schorey, C.
10.1101/2024.12.26.630400 — cancer biology — Posted on 2024-12-26
499 Retinal organoids mirror CRISPR/Cas9 gene editing efficiency observed in vivo
Pulman, J.; Malki, H.; Oudin, P.; Aydin, E.; Tran, S.; Visticot, L.; Robert, C.; De Cian, A.; As, M.; Goureau, O.; Concordet, J.-P.; Dalkara, D.
10.1101/2024.12.26.630388 — bioengineering — Posted on 2024-12-26
502 Pro-cognitive reshaping of neuronal dynamics by a human CSF-based factor
Dos Santos, M.; Forrest, M. P.; Bomba-Warczak, E. K.; Parnell, E.; Edassery, S. L.; Yang, K.; Hayes, L. N.; Coughlin, J. M.; Eckman, B. L.; Lammert, C.; Martin-de-Saavedra, M. D.; Barbolina, M.; Sawa, A.; Savas, J.; Penzes, P.
10.1101/2024.12.26.629959 — neuroscience — Posted on 2024-12-26
503 Aggression experience and observation promote shared behavioral and neural changes
Falkner, A. L.; Iravedra Garcia, J. M.; Guthman, E. M.; Cuturela, L. I.; Ocasio-Arce, E. J.; Pillow, J. W.
10.1101/2024.12.26.630396 — neuroscience — Posted on 2024-12-26
504 Ultrastructural membrane dynamics of mouse and human cortical synapses
Eddings, C. R.; Fan, M.; Imoto, Y.; Itoh, K.; McDonald, X.; Eilers, J.; Anderson, W. S.; Worley, P. F.; Lippmann, K.; Nauen, D. W.; Watanabe, S.
10.1101/2024.12.26.630393 — neuroscience — Posted on 2024-12-26
507 A new nanoDSF approach to anti-tubulin compounds screening revealed novel MTAs among approved drugs.
Baksheeva, V. E.; La Rocca, R.; Leloup, L.; Souberan, A.; Berges, R.; Allegro, D.; Derviaux, C.; Pasquier, E.; Roche, P.; Morelli, X.; Devred, F.; Tchoghandjian, A.; Tabouret, E.; Golovin, A. V.; Tsvetkov, P. O.
10.1101/2024.12.26.630395 — cancer biology — Posted on 2024-12-26
510 Visual circuitry for distance estimation in Drosophila
Shomar, J.; Wu, E.; Au, B.; Maier, K.; Zhou, B.; Matos, N.; Sager, G. C.; Santana, G.; Tanaka, R.; Gish, C.; Clark, D. A.
10.1101/2024.12.25.630346 — neuroscience — Posted on 2024-12-26
513 The 1001G+ project: A curated collection of Arabidopsis thaliana long-read genome assemblies to advance plant research
Alonso-Blanco, C. C.; Ashkenazy, H.; Baduel, P.; Bao, Z.; Becker, C.; Caillieux, E.; Colot, V.; Crosbie, D.; De Oliveira, L.; Fitz, J.; Fritschi, K.; Grigoreva, E.; Guo, Y.; Habring, A.; Henderson, I.; Hou, X.-H.; Hu, Y.; Igolkina, A.; Kang, M.; Kemen, E.; Kersey, P. J.; Kornienko, A.; Lian, Q.; Liu, H.; Liu, J.; Lucke, M.; Mayjonade, B.; Mercier, R.; Molla Morales, A.; Movilli, A.; Murray, K. D.; Naish, M.; Nordborg, M.; Rabanal, F. A.; Roux, F.; Schandry, N.; Schneeberger, K.; Schwab, R.; Shirsekar, G.; Sushko, S.; Tao, Y.; Teasdale, L.; Vorbrugg, S.; Weigel, D.; Xian, W.
10.1101/2024.12.23.629943 — genomics — Posted on 2024-12-26
514 Impact of Antibiotics on the Genomic Expression of Pseudomonas aeruginosa in the East African Community: A Systematic Review
Vandu, C. D.; Fasongbon, I. V.; Agbaje, A. B.; Njideka, A. C.; Wusa, M.; Ikuomola, E. O.; Dangana, R. S.; Mitaki, N. B.; Usman, I. M.; Oviosun, A.; Mbyemeire, H.; Umorem, E.; Jakheng, S. P. E.; Mbina, S. A.; Alum, E. U.; Abubarkar, I. B.; Terkimbi, S. D.; Robert, S.; Agwu, E.; Aja, P. M.; Mumbua, A. M.
10.1101/2024.12.23.630126 — genomics — Posted on 2024-12-26
518 Universality of representation in biological and artificial neural networks
Hosseini, E. A.; Casto, C. C.; Zaslavsky, N.; Conwell, C.; Richardson, M.; Fedorenko, E.
10.1101/2024.12.26.629294 — neuroscience — Posted on 2024-12-26
522 Hindering memory suppression by perturbing the right dorsolateral prefrontal cortex
Stramaccia, D. F.; Bergmann, F.; Lingelbach, K.; Numssen, O.; Hartwigsen, G.; Benoit, R. G.
10.1101/2024.12.23.630167 — neuroscience — Posted on 2024-12-26
524 A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses
Powell, A. E.; Caruso, H.; Park, S.; Chen, J.-L.; O'Rear, J.; Ferrer, B. J.; Belnap, D. M.; Walker, A.; Bruening, A.; Hartwig, A.; Ahyong, V.; Dougherty, C. S.; Bowen, R. A.; Ledgerwood, J. E.; Kay, M. S.; Weidenbacher, P. A.- B.; Palanski, B. A.
10.1101/2024.07.01.601243 — biochemistry — Posted on 2024-12-26
526 Structure-Based Design of Small-Molecule Inhibitors of Human Interleukin-6
Joshi, A.; Xiao, Z.; Suman, S.; Cooper, C.; Ha, K.; Agarwal, R.; Carson, J.; Quarles, L. D.; Smith, J.; Gupta, M.
10.1101/2024.12.26.630392 — bioinformatics — Posted on 2024-12-26
528 MethylQUEEN: A Methylation Encoded DNA Foundation Model
Li, M.; Gu, R.; Fan, S.; Fan, Y.; He, B.; Yang, J.; Chen, Y.; Xin, M.; Wen, H.; Yi, C.
10.1101/2024.12.26.630389 — genomics — Posted on 2024-12-26
529 FAM162A is Crucial for Mitochondrial Structure, Dynamics, and Bioenergetics, Driving Cellular Protection and Longevity
Matamoros, A.; Soffia, J. P.; Munoz, M.; Maturana, M.; Gonzalez-Ibanez, A.; Gomez-Lillo, G.; Astorga, C.; Ruiz, L. M.; Jorquera, R.; Elorza, A. A.
10.1101/2024.12.26.630390 — cell biology — Posted on 2024-12-26
531 Seroprevalence and cross-reactivity of neutralizing antibodies to six types of adenoviruses
Zubkova, O. V.; Ozharovskaia, T. A.; Popova, O.; Vavilova, I. V.; Zrelkin, D. I.; Goldovskaya, P. P.; Voronina, D. V.; Dolzhikova, I. V.; Grousova, D. M.; Shcheblyakov, D. V.; Logunov, D. Y.; Gintsburg, A. L.
10.1101/2024.12.26.630365 — immunology — Posted on 2024-12-26
532 Ovalbumin-loaded mesoporous silica nanoparticles for allergen specific immunotherapy
Perez-Moreno, A. M.; Torres, P.; Martin-Astorga, M. d. C.; Cuevas-Delgado, P.; Garcia-Esteban, I.; Cespedes, J. A.; Montanez, M. I.; Torres, M. J.; Aranda, C. J.; Mayorga, C.; Paris, J. L.
10.1101/2024.12.26.630362 — immunology — Posted on 2024-12-26
535 Transcontinental patterns in floral pigment frequencies among animal-pollinated species
Narbona, E.; del Valle, J. C.; Whittall, J. W.; Leon-Osper, M.; Buide, M. L.; Pulgar, I.; Camargo, M. G. G.; Morellato, L. P. C.; Rodriguez-Castaneda, N.; Rossi, V.; Conrad, K.; Hernandez-Mena, J.; Ortiz, P. L.; Arista, M.
10.1101/2024.12.26.630375 — plant biology — Posted on 2024-12-26
536 Tumour-derived LAMA5 is critical for tumour initiation and controls progression and phenotype in luminal breast cancer
Ritchie, A.; Dhawan, P.; Kailari, E.; Linden, J.; Blaas, L.; Izzi, V.; Katajisto, P.; Englund, J. I.
10.1101/2024.12.26.630367 — cancer biology — Posted on 2024-12-26
541 Sugarcane carries relatively larger family of CAMTA transcription factors, active against drought stress
Costa da Silva, V. L.; Martinez, A. M.; Vincente, M. A.; Alam, M.; Noman, M.; Junior, A. C.
10.1101/2024.12.26.630382 — bioinformatics — Posted on 2024-12-26
543 Wafer-scale integration of alpha-quartz thin films towards super high frequency piezoelectric bioNEMS for arbovirus detection
Rathar, R.; Sanchez-Fuentes, D.; Ding, S.; Jolly, C.; Andre, C.; Desgarceaux, R.; Garcia, R.; Gazquez, J.; Plana, S.; Picas, L.; Carretero, A.
10.1101/2024.12.26.630366 — bioengineering — Posted on 2024-12-26
544 Chronic infection of Caenorhabditis elegans by Orsay virus induces age-dependent immunity and superinfection exclusion
Castiglioni, V. G.; Villena-Gimenez, A.; Gonzalez-Sanchez, A.; Toft, C.; Gomez, G.; Elena, S. F.
10.1101/2024.12.26.630373 — genomics — Posted on 2024-12-26
547 Pathogens spread by high-altitude windborne mosquitoes
Bamou, R.; Dao, A.; Yaro, A. S.; Kouam, C.; Ergunay, K.; Bourkey, B. P.; Diallo, M.; Sanogo, Z. L.; Djibril, S.; Afrane, Y.; Mohammed, A. R.; Owusu-Asenso, C. M.; Akosah-Brempong, G.; Pambit-Zong, C. M.-A.; Krajacich, B. J.; Faiman, R.; Pacheco, M. A.; Escalante, A. A.; Weaver, S. C.; Nartey, R.; Chapman, J.; Reynolds, D. R.; Linton, Y.-M.; Lehmann, T.
10.1101/2024.12.26.630351 — microbiology — Posted on 2024-12-26
550 Revival of traditional agricultural systems - A multidisciplinary on-farm survey of maize-bean intercropping reveals unexpected competition effects on bean.
Vazeux-Blumental, N.; Mathieu, L.; Trabac, T.; Palaffre, C.; Lagardere, B.; Carraretto, M.; Bauland, C.; Le Guilloux, M.; Paysant-Le Roux, C.; Caius, J.; Marmagne, A.; Enjalbert, J.; Flutre, T.; Le Cadre, E.; Parnaudeau, V.; Muller, D.; Moenne-Loccoz, Y.; Manicacci, D.; Tenaillon, M. I.
10.1101/2024.04.24.590929 — plant biology — Posted on 2024-12-26
552 PTEN neddylation aggravates CDK4/6 inhibitor resistance in breast cancer
Liu, F.; Liu, W.; Tan, Y.; Shang, Y.; Ling, S.; Jiang, X.; Zhang, Z.; Sun, S.; Xie, P.
10.1101/2024.08.06.606911 — cell biology — Posted on 2024-12-26
556 The genomic and epigenomic dynamics of hemizygous genes across crops with contrasting mating systems
Peng, Y.; Wang, Y.; Liu, Y.; Fang, X.; Cheng, L.; Long, Q.; Xu, Q.; Wang, N.; Zhang, F.; Liu, Z.; Xiao, H.; Hu, W.; Chen, S.; Huang, S.; Gaut, B. S.; Zhou, Y.
10.1101/2024.05.24.595664 — plant biology — Posted on 2024-12-26
559 An integrated and scalable rodent cage system enabling continuous computer vision-based behavioral analysis and AI-enhanced digital biomarker development
Robertson, T. L.; Ellis, M.; Bratcher-Petersen, N. A.; Ruidiaz, M. E.; Harada, K.; Toburen, D.; Oberhauser, J. P.; Grzenda, D.; Peltier, N.; Raza, M.; Benway, J.; Kiros, J.; Kumar, V.
10.1101/2024.12.18.629281 — animal behavior and cognition — Posted on 2024-12-26
560 A Double-Blind Replication Attempt of Offline 5Hz-rTUS-Induced Corticospinal Excitability
Fong, P.-Y.; Kop, B. R.; Evans, C.; Wijaya, V. G.; Lin, Y.; Cappotto, D.; Lee, J. S. A.; Latorre, A.; Song, J.; Treeby, B. E.; Martin, E.; Rothwell, J.; Verhagen, L.; Bestmann, S.
10.1101/2024.11.25.625187 — neuroscience — Posted on 2024-12-26
561 Scaling up drug combination surface prediction
Huusari, R.; Wang, T.; Szedmak, S.; Dias, D.; Aittokallio, T.; Rousu, J.
10.1101/2024.12.24.630218 — bioinformatics — Posted on 2024-12-26
562 CLEM-Reg: An automated point cloud based registration algorithm for correlative light and volume electron microscopy
Krentzel, D.; Elphick, M.; Domart, M.-C.; Peddie, C. J.; Laine, R. F.; Shand, C.; Henriques, R.; Collinson, L. M.; Jones, M. L.
10.1101/2023.05.11.540445 — cell biology — Posted on 2024-12-26
565 Longitudinal assessment of DREADD expression and efficacy in the monkey brain
Nagai, Y.; Hori, Y.; Inoue, K.-i.; Hirabayashi, T.; Mimura, K.; Oyama, K.; Miyakawa, N.; Hori, Y.; Iwaoki, H.; Kumata, K.; Zhang, M.-R.; Takada, M.; Higuchi, M.; Minamimoto, T.
10.1101/2024.12.26.630299 — neuroscience — Posted on 2024-12-26
569 Direction and modality of transcription changes caused by TAD boundary disruption in Slc29a3/Unc5b locus depends on tissue-specific epigenetic context
Salnikov, P. A.; Belokopytova, P. S.; Yan, A. P.; Viesna, E.; Korablev, A. N.; Serova, I. A.; Lukyanchikova, V. A.; Stepanchuk, Y. K.; Torgunakov, N. Y.; Tikhomirov, S. A.; Fishman, V. S.
10.1101/2024.08.16.608309 — genetics — Posted on 2024-12-26
573 Comparison of whole-genome assemblies of European river lamprey (Lampetra fluviatilis) and brook lamprey (Lampetra planeri)
Torresen, O. K.; Garmann-Aarhus, B.; Hoff, S. N. K.; Jentoft, S.; Svensson, M.; Schartum, E.; Tooming-Klunderud, A.; Skage, M.; Krabberod, A.; Vollestad, L. A.; Jakobsen, K. S.
10.1101/2024.12.06.627158 — genomics — Posted on 2024-12-26
574 SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms
Hasanaj, E.; Beaulieu, D.; Wang, C.; Hu, Q.; Bueno, M.; Sembrat, J. C.; Pineda, R. H.; Melo-Narvaez, M. C.; Cardenes, N.; Yanwu, Z.; Yingze, Z.; Lafyatis, R.; Morris, A.; Mora, A.; Rojas, M.; Li, D.; Rahman, I.; Pryhuber, G. S.; Lehmann, M.; Alder, J.; Gurkar, A.; Finkel, T.; Ma, Q.; Poczos, B.; Bar-Joseph, Z.; Eickelberg, O.; Königshoff, M.
10.1101/2024.12.21.629928 — genomics — Posted on 2024-12-26
576 Multi-omics analysis of long-term cultured human islets
Sun, G.; Qi, M.; Sun, O.; Lizar, E. M.; Hussey, D.; Shi, Y.; Riggs, A. D.
10.1101/2024.12.25.626491 — molecular biology — Posted on 2024-12-25
578 Stress-induced organismal death is genetically regulated by the mTOR-Zeste-Phae1 axis
Matsumura, T.; Ryuda, M.; Matsumoto, H.; Kamiyama, T.; Kondo, S.; Nakamura, A.; Hayakawa, Y.; Niwa, R.
10.1101/2024.12.25.630336 — physiology — Posted on 2024-12-25
579 A single-cell map of hypertension
Qiu, Q.; Liu, Y.; Xue, H.; Pandey, R.; He, L.; Liu, J.; Liu, P.; Therani, B.; Kumar, V.; Huang, J.; Guenther, M.; Usa, K.; Grzybowski, M.; Avond, M. A. V.; Greene, A. S.; Cowley, A. W.; Rao, S.; Geurts, A. M.; Liang, M.
10.1101/2024.12.25.630332 — physiology — Posted on 2024-12-25
586 Glutathione Effects on Liver Enzymes and Serum Electrolyte in Mice Exposed to 850 1900 MHz Mobile Phone Radiation
Binhambali, A.; Ahmed, A. T.; Umar, A. H.; Abdoulie, A. T.; Mukhtar, A. I.; Pate, A. A.; Nuhu, A.; Ipinlaiye, T.; Ismail, U.; Kolo, H. M.; Magaji, R. A.
10.1101/2024.05.24.595675 — physiology — Posted on 2024-12-25
587 Accurate de novo design of a voltage-gated anion channel
Zhou, C.; Li, H.; Wang, J.; Chu, Z.; Sun, S.; Sun, K.; Zhu, A.; Wang, J.; Jin, X.; Yang, F.; El-Din, T. M. G.; Wu, K.; Lu, P.
10.1101/2024.12.25.630309 — synthetic biology — Posted on 2024-12-25
590 Global and genetic regulation of gene expression in human endothelial and vascular smooth muscle cells
Liu, P.; Ray, A.; Liu, Y.; Mishra, M. K.; Qiu, Q.; Pandey, R.; Therani, B.; Huang, J.; Ren, J.; Stelloh, C.; Bai, X.; Greene, A. S.; Cowley, A. W.; Geurts, A. M.; Rao, S.; Liang, M.
10.1101/2024.12.25.630318 — genomics — Posted on 2024-12-25
591 WNT signaling coordinately controls mouse limb bud outgrowth and establishment of the digit-interdigit pattern
Malkmus, J.; Morabito, A.; Lopez-Delisle, L.; Avino Esteban, L.; Mayran, A.; Zuniga, A.; Sharpe, J.; Zeller, R.; Sheth, R.
10.1101/2024.12.25.629665 — developmental biology — Posted on 2024-12-25
592 Enhancing Collagen Biosynthesis in Mammalian Cells Through Hypoxia-Mimetic Prolyl Hydroxylase Inhibition
Shahar, B.; Kilimnik, I.; Adriana Lifshits, L.; Netti, F.; Sova, M.; Rosin-Grunewald, D.; Gal, M.; Adler-Abramovich, L.
10.1101/2024.12.25.630305 — cell biology — Posted on 2024-12-25
593 LPS-induced sepsis disrupts brain activity in a region- and vigilance-state specific manner
Leemburg, S.; Kala, A.; Nataraj, A.; Karkusova, P.; Baindur, S.; Suresh, A.; Blahna, K.; Jezek, K.
10.1101/2024.12.25.630319 — neuroscience — Posted on 2024-12-25
595 Nectin-4 PET For Optimizing Enfortumab Vedotin Dose-Response In Urothelial Carcinoma
Mishra, A.; Sharma, A. K.; Gupta, K.; Banka, D.; Johnson, B. A.; Hoffman-Censits, J.; Huang, P.; McConkey, D. J.; Nimmagadda, S.
10.1101/2024.12.25.630315 — cancer biology — Posted on 2024-12-25
596 A somatic multiple myeloma mutation unravels a mechanism of oligomerization-mediated product inhibition in GGPPS
Yehia, R.; Portasikova, J. M.; Mor Yosef, R.; Da'adoosh, B.; Kadek, A.; Man, P.; Giladi, M.; Haitin, Y.
10.1101/2024.12.25.628878 — biochemistry — Posted on 2024-12-25
597 Mechanistic studies of PFKFB2 reveals a novel inhibitor of its kinase activity
Eyster, C.; Matsuzaki, S.; Pranay, A.; Giorgione, J. R.; Faakye, A.; Ahmed, M.; Humphries, K. M.
10.1101/2024.12.25.630325 — biochemistry — Posted on 2024-12-25
598 Elucidation of gene clusters underlying withanolide biosynthesis in ashwagandha through yeast metabolic engineering
Reynolds, E.; Trauger, M.; Li, F.-S.; Huang, J.; Moss, T.; Christ, B.; Xu, M.; Knoch, E.; Weng, J.-K.
10.1101/2024.12.24.630284 — biochemistry — Posted on 2024-12-25
606 Metagenomic analysis of age-dependent microbial dynamics in dual-media rapid sand filters treating groundwater
Boersma, A. S.; Haukelidsaeter, S. S.; Naletto, F.; Slomp, C. P.; van der Wielen, P. W.; van Kessel, M. A.; Luecker, S.
10.1101/2024.12.25.630300 — microbiology — Posted on 2024-12-25
607 The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic Mucin
Humeidi, R.; Rapley, N.; Gu, X.; An, J. S.; Ananthakrishnan, A. N.; Creasey, E. A.; Daly, M. J.; Schreiber, S. L.; Graham, D. B.; Seyedsayamdost, M. R.; Xavier, R. J.
10.1101/2024.12.24.630288 — immunology — Posted on 2024-12-25
610 p75NTR modulation by LM11A-31 counteracts oxidative stress and cholesterol dysmetabolism in a rotenone-induced cell model of Parkinson's disease
Pensabene, D.; Martella, N.; Scavo, G.; Varone, M.; Bisesto, E.; Cavicchia, F.; Colardo, M.; Moreno, S.; Segatto, M.
10.1101/2024.12.25.630306 — neuroscience — Posted on 2024-12-25
612 A vestibulospinal pathway for context-dependent motor control of the mouse tail
Lacava, S. A.; Isilak, N.; Ranawat, N.; Katzke, J.; Hoedemaker, J. F. H.; Yoshida, Y.; Uusisaari, M. Y.
10.1101/2024.12.25.630321 — neuroscience — Posted on 2024-12-25
619 ChromBPNet: bias factorized, base-resolution deep learning models of chromatin accessibility reveal cis-regulatory sequence syntax, transcription factor footprints and regulatory variants
Pampari, A.; Shcherbina, A.; Kvon, E.; Kosicki, M.; Nair, S.; Kundu, S.; Kathiria, A. S.; Risca, V. I.; Kuningas, K.; Alasoo, K.; Greenleaf, W.; Pennacchio, L.; Kundaje, A.
10.1101/2024.12.25.630221 — genetics — Posted on 2024-12-25
623 Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication
Aierken, D.; Zhang, V.; Sealfon, R.; Marecki, J.; Raney, K. D.; Gladfelter, A.; Joseph, J. A.; Roden, C.
10.1101/2024.12.23.630161 — biochemistry — Posted on 2024-12-25
624 Selective ion binding and uptake shape the microenvironment of biomolecular condensates
Smokers, I. B. A.; Lavagna, E.; Freire, R. V. M.; Paloni, M.; Voets, I. K.; Barducci, A.; White, P. B.; Khajehpour, M.; Spruijt, E.
10.1101/2024.12.24.630169 — biophysics — Posted on 2024-12-25
626 Comparative genomics of the sexually transmitted parasite Trichomonas vaginalis reveals relaxed and convergent evolution and genes involved in spillover from birds to humans
Sullivan, S. A.; Orosco, J. C.; Callejas-Hernandez, F.; Blow, F.; Lee, H.; Ranallo-Benavidez, T.; Peters, A.; Raidal, S.; Girard, Y. A.; Johnson, C. K.; Rogers, K.; Gerhold, R.; Mangelson, H.; Liachko, I.; Srivastava, H.; Chandler, C.; Berenberg, D.; Bonneau, R.; Huang, P.-J.; Yeh, Y.-M.; Lee, C.-C.; Liu, H.; Tang, P.; Chen, T.-W.; Schatz, M.; Carlton, J. M.
10.1101/2024.12.22.629724 — microbiology — Posted on 2024-12-25
629 Neurovascular coupling conversely modulates emotion
Ruan, J.; Quan, X.; Zhang, Y.; Xie, H.; Zhang, D.; Wang, W.; Zhao, B.; Lu, D.; Jia, J.-M.
10.1101/2023.02.13.527949 — neuroscience — Posted on 2024-12-25
630 Overexpression of Xanthophyll Cycle Genes Leads to Faster NPQ Acclimation in the C4 Monocot Setaria viridis
Stone, W. D.; Acosta-Gamboa, L.; Kang, X.; zhang, f.; Owens, L.; Li, L.; Thielen, P. M.; Jander, G.; Gore, M. A.; Lawton, T. J.
10.1101/2024.12.23.630197 — plant biology — Posted on 2024-12-25
633 Higher basal tumor immune activity coupled with a systemic immune response improves liver cancer outcomes
Alipour Talash, G.; Vitale, D.; Langfelder, P.; Karimi Azardaryany, M.; Berry, M.; Belgard, T. G.; Choo, J.; Rogers, G.; Ho, V.; Ramezani-Moghadam, M.; Dervish, S.; Lai, J.; Gloss, B. S.; Worth, C. L.; McLeod, D.; Eslam, M.; Liddle, C.; Qiao, L.; George, J.; Esmaili, S.
10.1101/2022.04.16.488543 — cancer biology — Posted on 2024-12-25
634 dGAMLSS: An exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts
Hu, F.; Tong, J.; Gardner, M.; Lifespan Brain Chart Consortium, ; Chen, A. A.; Bethlehem, R. A. I.; Seidlitz, J.; Lee, H.; Alexander-Bloch, A.; Chen, Y.; Shinohara, R.
10.1101/2024.12.20.629834 — bioinformatics — Posted on 2024-12-25
638 Systematic Benchmarking of High-Throughput Subcellular Spatial Transcriptomics Platforms
Ren, P.; Zhang, R.; Wang, Y.; Zhang, P.; Luo, C.; Wang, S.; Li, X.; Zhang, Z.; Zhao, Y.; He, Y.; Zhang, H.; Li, Y.; Gao, Z.; Zhang, X.; Zhao, Y.; Liu, Z.; Meng, Y.; Zhang, Z.; Zeng, Z.
10.1101/2024.12.23.630033 — genomics — Posted on 2024-12-25
639 Understanding genetic architecture overcomes tradeoffs between seed quality and insect resistance
White, J. R.; McNellie, J. P.; Keepers, K. G.; Smart, B. C.; Portlas, Z. M.; Marcus, Z. E.; Kane, N. C.; Prasifka, J. R.; Hulke, B.
10.1101/2024.12.20.629859 — genetics — Posted on 2024-12-25
644 Prohibitin 2 is a Key Regulator of T Cell Proliferation, Differentiation, and Effector Functions in vivo
Vogt, J. F.; Merkwirth, C.; Adams-Quack, P.; Zurkowski, E.; Michna, T.; Nurbekova, A.; Distler, U.; Yurugi, H.; Reissig, S.; Wunderlich, F. T.; Rajalingam, K.; Tenzer, S.; Methner, A.; Langer, T.; Waisman, A.; Hoevelmeyer, N.
10.1101/2024.12.13.628303 — immunology — Posted on 2024-12-25
649 Glycan analysis probes inspired by human lectins for investigating host-microbe crosstalk
Ghosh, S.; Chorghade, R.; Diehl, R. C.; Dodge, G. J.; Bae, S.; Dugan, A. E.; Halim, M.; Wuo, M.; Bartlett, H.; Herndon, L. K.; Kiessling, L. L.; Imperiali, B.
10.1101/2024.12.24.630132 — biochemistry — Posted on 2024-12-25
650 Placental malaria is associated with a TLR-Endothelin-3-oxidative damage response in human placenta tissues
Chenge, S.; Mbalitsi, M.; Ngure, H.; Obimbo, M.; Singoei, M.; Kangogo, M.; Kanoi, B. N.; Gitaka, J.; Kobia, F. M.
10.1101/2024.04.17.589949 — cell biology — Posted on 2024-12-25
652 Unraveling the immunological roles of murine serum amyloid A3 in aortic immune cell subsets during atherosclerosis progression
Chou, T.-Y.; Ye, Y.-Z.; Lien, C.-J.; Wang, J.-C.; Yang, C.-H.; Chen, Y.-T.; Lin, I.-J.; Chao, P.-A.; Lin, J.-D.
10.1101/2024.07.09.602634 — immunology — Posted on 2024-12-25
654 Sporophyte Directed Gametogenesis via the Ubiquitin Proteasome System
Sivakumar, P.; Pandey, S.; Ramesha, A.; Davda, J. N.; Singh, A.; Kumar, C.; Gala, H. P.; Subbiah, V.; Adicherla, H.; Dhawan, J.; Aravind, L.; Siddiqi, I.
10.1101/2024.12.23.630054 — plant biology — Posted on 2024-12-25
657 Slow-growing Salmonella enterica Typhi mis-identified as Salmonella Gallinarum in Ibadan, Nigeria
Sunmonu, G. T.; Ogunleye, V. O.; Ikhimiukor, O. O.; Popoola, O. A.; Osadebamwen, P. E.; Kehinde, A.; Okeke, I. N.
10.1101/2024.12.24.630237 — microbiology — Posted on 2024-12-25
659 Effect of Stroma-directed Drugs in Combination with Chemotherapy Against Pancreatic Cancer- a Preclinical Study
Gupta, M.; Choi, H.; Furth, E. E.; Pickup, S.; Shaffer, S.; Clendenin, C.; Song, H. K.; Fan, Y.; Duda, J.; Gee, J. C.; Liu, F.; Cao, Q.; Karasic, T.; Rosen, M.; Dwyer, P. O.; Zhou, R.
10.1101/2024.12.24.630138 — cancer biology — Posted on 2024-12-25
661 Comprehensive analysis of macrophages infected with avirulent and virulent Mycobacterium tuberculosis uncovers distinct immune mechanisms and anti-TB effect of treated exosomes
Yang, L.; Lyu, L.; Li, C.; Zhang, X.; ju, y.; Zhang, J.; Liu, J.; yue, L.; Zhang, X.; Lu, D.; Yang, T.; Wang, P.; Wang, J.; Wang, X.; Sihong, X.; Sheng, Y.; Jiang, C.; Wang, J.; Hu, X.; Bahetibieke, T.; Zhang, Z.; Chen, F.
10.1101/2024.12.24.630227 — bioinformatics — Posted on 2024-12-25
662 Understanding the structure and mechanics of the sheep calcaneal enthesis: a relevant animal model for tissue engineering applications
Sensini, A.; Raimondi, L.; Malerba, A.; Peniche Silva, C. J.; Zucchelli, A.; Tits, A.; Ruffoni, D.; Blouin, S.; Hartmann, M. A.; van Griensven, M.; Moroni, L.
10.1101/2024.12.24.630234 — bioengineering — Posted on 2024-12-25
663 Crystal structure of Fatty Acid Thioesterase A bound by 129 fragments provides diverse development opportunities
Kot, E.; Ferla, M. P.; Hollinshead, P. H.; Tomlinson, C. W. E.; Fearon, D.; Aschenbrenner, J. C.; Koekemoer, L.; Winokan, M.; Fairhead, M.; Ni, X.; England, K. S.; Ortega Varga, L.; Montgomery, M. G.; Mulholland, N. P.; von Delft, F.
10.1101/2024.12.23.629660 — biochemistry — Posted on 2024-12-25
664 Maize and wild relatives show distinct patterns of genome downsizing following polyploidy
Snodgrass, S. J.; Woodhouse, M. R.; Seetharam, A. S.; Stitzer, M. C.; Hufford, M.
10.1101/2024.12.24.630189 — genomics — Posted on 2024-12-25
665 Cross comparison of imaging strategies of mitochondria in C. elegans during aging.
Kim, J.; Dutta, N.; Vega, M.; Bong, A.; Averbukh, M.; Aviles Barahona, R.; Alcala, A.; Holmes, J. T.; Garcia, G.; Higuchi-Sanabria, R.
10.1101/2024.12.24.630282 — cell biology — Posted on 2024-12-25
666 Inflammatory Monocytes Increase Prior to Detectable HIV-1 Rebound Viremia
Farrell-Sherman, A.; de la Force, N.; Prator, C.; Valieris, R.; Azam, W.; Silva, I.; Deeks, S.; Thanh, C.; Bosch, R.; Henrich, T. J.; Cohn, L. B.
10.1101/2024.12.24.630257 — immunology — Posted on 2024-12-25
667 The CD4 T cell-independent IgG response during persistent virus infection favors emergence of neutralization-escape variants
Ayers, K. N.; Lauver, M. D.; Alexander, K. M.; Jin, G.; Paraiso, K.; Ochetto, A.; Garg, S.; Goetschius, D. J.; Hafenstein, S. L.; Wang, J. C.-Y.; Lukacher, A. E.
10.1101/2024.12.22.629980 — immunology — Posted on 2024-12-25
668 Comprehensive profiling of small RNAs and their changes and linkages to mRNAs in schizophrenia and bipolar disorder
Nersisyan, S.; Loher, P.; Nazeraj, I.; Shao, Z.; Fullard, J.; Voloudakis, G.; Girdhar, K.; Roussos, P.; Rigoutsos, I.
10.1101/2024.12.24.630254 — neuroscience — Posted on 2024-12-25
669 Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers
Lum, M. R.; Patel, S.; Graham, H. K.; Zhao, M.; Yi, Y.; Li, L.; Yao, M.; La Torre, A.; Della Santina, L.; Han, Y.; Hu, Y.; Welsbie, D. S.; Duan, X.
10.1101/2024.12.24.630272 — neuroscience — Posted on 2024-12-25
671 Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions
Ueno, A.; Sakuta, K.; Ono, H.; Tokumoto, H.; Watanabe, M.; Nishimoto, T.; Konishi, T.; Mizuno, S.; Miyoshi, J.; Takai, Y.; Tachibana, M.; Koike, C.
10.1101/2024.12.24.630271 — neuroscience — Posted on 2024-12-25
673 WWOX deficiency impairs neurogenesis and neuronal function in human organoids
Steinberg, D. J.; Zonca, A.; Rosh, I.; Kustanovich, I.; Maroun, K.; Stern, S.; Davila-Velderrain, J.; Aqeilan, R. I.
10.1101/2024.12.22.630016 — neuroscience — Posted on 2024-12-25
674 Virus-free continuous directed evolution in human cells using somatic hypermutation
Bram, S.; Quenneville, J.; Lindsey, G.; Leach, S.; Guthmiller, J. J.; Mehta, A. P.
10.1101/2024.12.24.629435 — synthetic biology — Posted on 2024-12-25
676 The role of inflammation in a humanized mouse model of transthyretin cardiac amyloidosis
Wu, X.; Cai, N.; Jimenez, I.; Kitakata, H.; Fahed, G.; Evangelisti, A.; Jha, A.; Woo, J.; Liao, R.; Alexander, K. M.
10.1101/2024.12.24.629308 — pathology — Posted on 2024-12-25
680 Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques
Metzler, L. A. P.; Metzger Ph.D., J. M.; Gerred B.S., K.; Emborg M.D. Ph.D, M. E.; Kapoor Ph.D., A.
10.1101/2024.12.20.629742 — physiology — Posted on 2024-12-25
686 Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions
Sattin, A.; Nardin, C.; Daste, S.; Moroni, M.; Reddy, I.; Liberale, C.; Panzeri, S.; Fleischmann, A.; Fellin, T.
10.1101/2024.07.24.604890 — neuroscience — Posted on 2024-12-24
687 Social and environmental predictors of gut microbiome age in wild baboons
Dasari, M. R.; Roche, K. E.; Jansen, D.; Anderson, J.; Alberts, S. C.; Tung, J.; Gilbert, J. A.; Blekhman, R.; Mukherjee, S.; Archie, E.
10.1101/2024.08.02.605707 — evolutionary biology — Posted on 2024-12-24
689 Characterizing postoperative T and B cell dysfunction in cancer surgery patients, using COVID-19 as a model antigen
Olanubi, O.; MacDonald, R.; Dion, T.; Alam, R.; De Souza, C. T.; Hu, R.; Crawley, A. M.; Auer, R. C.
10.1101/2024.12.23.629453 — immunology — Posted on 2024-12-24
691 The Rhizobial effector NopT targets Nod factor receptors to regulate symbiosis in Lotus japonicus
Bao, H.; Wang, Y.; Li, H.; Wang, Q.; Lei, Y.; Ye, Y.; Wadood, S. F.; Zhu, H.; Staehelin, C.; Stacey, G.; Xu, S.; Cao, Y.
10.1101/2024.03.06.583716 — plant biology — Posted on 2024-12-24
695 Alternating hemiplegia of childhood associated mutations in Atp1a3 reveal diverse neurological alterations in mice.
Terrey, M.; Krivoshein, G.; Adamson, S. I.; Arystarkhova, E.; Anderson, L.; Szwec, J.; McKee, S.; Jones, H.; Perkins, S.; Selvam, V.; Piec, P.-A.; Chhaya, D.; Dehn, A.; Zuberi, A.; Murray, S. A.; Morsci, N. S.; Sweadner, K. J.; Knowles, D. A.; Tolner, E. A.; van den Maagdenberg, A. M. J. M.; Lutz, C. M.
10.1101/2024.12.24.630241 — neuroscience — Posted on 2024-12-24
696 Modeling the emergent metabolic potential of soil microbiomes in Atacama landscapes
Andreani-Gerard, C. M.; Jimenez, N. E.; Palma, R.; Muller, C.; Hamon-Giraud, P.; Le Cunff, Y.; Cambiazo, V.; Gonzalez, M.; Siegel, A.; Frioux, C.; Maass, A.
10.1101/2024.12.23.630026 — systems biology — Posted on 2024-12-24
697 Immunocompetent Cell Targeting by Food-Additive Titanium Dioxide
Wills, J. W.; Dabrowska, A.; Robertson, J.; Miniter, M.; Riedle, S.; Summers, H.; Hewitt, R.; Fathima, A.; Barreto da Silva, A.; Bastos, C.; Micklethwaite, S.; Keita, A.; Soderholm, J.; Roy, N.; Otter, D.; Jugdaohsingh, R.; Mastroeni, P.; Brown, A. P.; Rees, P.; Powell, J. J.
10.1101/2024.04.16.589772 — pharmacology and toxicology — Posted on 2024-12-24
698 Improved detection of differentially abundant proteins through FDR-control of peptide-identity-propagation
Solivais, A. J.; Boekweg, H.; Smith, L. M.; Shortreed, M. M.; Noble, W. S.; Payne, S. H.; Keich, U.
10.1101/2024.11.15.623880 — bioinformatics — Posted on 2024-12-24
700 A photoswitchable positive allosteric modulator to control the activation of the metabotropic glutamate receptor 5 by light
Dumazer, A.; Borras-Tuduri, R.; Truong, I.; Cong, X.; Malhaire, F.; Gomez-Santacana, X.; Givalois, L.; Lebon, G.; Llebaria, A.; Goudet, C.
10.1101/2024.12.24.629646 — pharmacology and toxicology — Posted on 2024-12-24
701 sc-SPLASH provides ultra-efficient reference-free discovery in barcoded single-cell sequencing
Dehghannasiri, R.; Kokot, M.; Starr, A. L.; Maziarz, J.; Gordon, T.; Tan, S. Y.; Wang, P. L.; Voskoboynik, A.; Musser, J. M.; Deorowicz, S.; Salzman, J.
10.1101/2024.12.24.630263 — bioinformatics — Posted on 2024-12-24
703 A reference metagenome sequence of the lichen Cladonia rangiformis
Heuberger, M.; Wehrkamp, C. M.; Pfammatter, A.; Poretti, M.; Graf, J. P.; Herger, A.; Isaksson, J.; Schlagenhauf, E.; Honegger, R.; Wicker, T.; Sotiropoulos, A. G.
10.1101/2024.12.24.630239 — evolutionary biology — Posted on 2024-12-24
704 Genomic characterization of novel bat kobuviruses in Madagascar: implications for viral evolution and zoonotic risk
Gonzalez, F. L.; Ranaivoson, H. C.; Andrianiaina, A.; Andry, S.; Raharinosy, V.; Randriambolamanantsoa, T. H.; Lacoste, V.; Dussart, P.; Heraud, J.-M.; Brook, C. E.
10.1101/2024.12.24.630179 — evolutionary biology — Posted on 2024-12-24
705 Structural Enzymology, Phylogenetics, Differentiation, and Symbolic Reflexivity at the Dawn of Biology
Carter, C. W.; Tang, G. Q.; Patra, S. K.; Betts, L.; Dieckhaus, H.; Kuhlman, B.; Douglas, J.; Wills, P.; Bouckaert, R.; Popovic, M.; Ditzler, M.
10.1101/2024.12.17.628912 — evolutionary biology — Posted on 2024-12-24
706 Delayed dichromatism in waterfowl as a convenient tool for assessing vital rates
Tableau, A.; Henderson, I.; Reeber, S.; Guillemain, M.; Maillard, J.-F.; Caizergues, A.
10.1101/2024.06.04.597326 — ecology — Posted on 2024-12-24
707 A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture
Pudlowski, R.; Xu, L.; Milenkovic, L.; Kumar, C.; Hemsworth, K.; Aqrabawi, Z.; Stearns, T.; Wang, J. T.
10.1101/2024.04.19.590208 — cell biology — Posted on 2024-12-24
709 Dynamics of striatal action selection and reinforcement learning
Lindsey, J.; Markowitz, J. E.; Gillis, W. F.; Datta, S. R.; Litwin-Kumar, A.
10.1101/2024.02.14.580408 — neuroscience — Posted on 2024-12-24
711 A conformational fingerprint for amyloidogenic light chains.
Paissoni, C.; Puri, S.; Broggini, L.; Sriramoju, M. K.; Maritan, M.; Russo, R.; Speranzini, V.; Ballabio, F.; Nuvolone, M.; Merlini, G.; Palladini, G.; Hsu, S.-T. D.; Ricagno, S.; Camilloni, C.
10.1101/2024.07.12.603200 — biophysics — Posted on 2024-12-24
717 Entamoeba histolytica extracellular vesicles drive pro-inflammatory monocyte signaling
Honecker, B.; Bärreiter, V. A.; Höhn, K.; Horvath, B.; Harant, K.; Galal Metwally, N.; Marggraff, C.; Anders, J.; Leyk, S.; Martinez-Tauler, M. d. P.; Bea, A.; Hansen, C.; Fehling, H.; Lütkemeyer, M.; Lorenzen, S.; Franzenburg, S.; Lotter, H.; Bruchhaus, I.
10.1101/2024.12.24.630232 — immunology — Posted on 2024-12-24
720 Mechanistic origins of temperature scaling in the early embryonic cell cycle
Rombouts, J.; Tavella, F.; Vandervelde, A.; Phong, C.; Ferrell, J.; Yang, Q.; Gelens, L.
10.1101/2024.12.24.630245 — systems biology — Posted on 2024-12-24
721 Laser speckle imaging of hepatic microcirculation
Zhukov, O.; Postnov, D. D.; Hejn, K. H.; Ravnskjaer, K.; Sosnovtseva, O.
10.1101/2024.12.24.629390 — physiology — Posted on 2024-12-24
722 Identification of SMARCA1 as a key regulator for Colorectal Cancer
Fu, C.; Duan, S.; Zhang, C.; Cui, X.; Wang, F.; Wang, L.; Hu, J.; Li, T.; Li, L.
10.1101/2024.12.24.630213 — cancer biology — Posted on 2024-12-24
733 Genome-wide Mapping Eukaryotic Open Chromatin Regions with Double-Stranded DNA Deaminase
Dong, W.; Zhang, J.; Dai, L.; Wang, Z.; Pang, Y.; He, R.; Ren, J.; Liu, Y.; Tian, Y.; Xie, X. S.
10.1101/2024.12.24.630236 — genomics — Posted on 2024-12-24
735 Increased versatility and convenience: advances and strategy optimization of ReMOT-mediated genetic modification in insects
Liang, X.; Zhou, C.; Hong, J.; Jiang, Y.; Li, L.; Xie, X.; Wang, S.; Zou, Q.; Yang, X.; Xiang, K.; Ma, J.; Qiao, L.; Chen, B.; Sun, W.
10.1101/2024.12.24.629949 — genetics — Posted on 2024-12-24
737 Restoring oxidative phosphorylation enhances osteogenesis in mitochondrial DNA translation defective human bone marrow stromal cells
Fernandez Guerra, P.; Kjaer, P. K.; Terp, S. K.; Thomsen, J. S.; Aldana, B.; Renkema, H.; Smeitink, J.; Andersen, P. H.; Palmfeldt, J.; Soe, K.; Andersen, T. L.; Kassem, M.; Frost, M.; Frekeriksen, A.
10.1101/2024.12.24.629993 — cell biology — Posted on 2024-12-24
738 Cigarette smoke induces PPP1R15A via oxidative stress to modulate inflammatory cytokine production by bronchial epithelial cells
Amatngalim, G. D.; van der Does, A. M.; Zarcone, M.; Malzer, E.; Bradley, J.; Belvisi, M.; Birrell, M.; van Schadewijk, A.; Hiemstra, P. S.; Marciniak, S. J.
10.1101/2024.12.24.630242 — cell biology — Posted on 2024-12-24
740 Generalists in a Specialist World: Vibrio-Phages with Broad Host Range
Bernard, C.; Labreuche, Y.; Diarra, C.; Daszkowski, P.; Cahier, K.; Goudenege, D.; Lamarche, M.; Whitfield, G. B.; Lang, M.; Valencia, J.; Groseille, J.; Piel, D.; Brun, Y. V.; Rocha, E.; Le Roux, F.
10.1101/2024.12.24.630238 — microbiology — Posted on 2024-12-24
741 New isolate genomes and global marine metagenomes resolve ecologically relevant units of SAR11
Freel, K. C.; Tucker, S. J.; Freel, E. B.; Giovannoni, S. J.; Eren, A. M.; Rappe, M. S.
10.1101/2024.12.24.630191 — microbiology — Posted on 2024-12-24
742 Reactivation of reward representations associated with the reinforcement of behavior
Tong, A. P. S.; Sreekumar, V.; Inati, S. K.; Zaghloul, K. A.; Woolrich, M. W.
10.1101/2024.12.23.628672 — neuroscience — Posted on 2024-12-24
743 Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea
Ivanchenko, M. V.; Booth, K. T. A.; Karavitaki, D. K.; Antonellis, L. M.; Nagy, M. A.; Peters, C. W.; Price, S.; Li, Y.; Lytvyn, A.; Ward, A.; Griffith, E. C.; Hrvatin, S.; Greenberg, M. E.; Corey, D. P.
10.1101/2024.12.24.630240 — neuroscience — Posted on 2024-12-24
744 A single Citrobacter rodentium infection in Pink1 knockout and wild type mice leads to regional blood-brain-barrier perturbation and glial activation without dopamine neuron axon terminal loss
Mukherjee, S.; Grouza, V.; Tchung, A.; Even, A.; Yaqubi, M.; Tuznik, M.; Cannon, T.; Recinto, S. J.; Gavino, C.; Bourque, M.-J.; McBride, H. M.; Desjardins, M.; Gruenheid, S.; Stratton, J. A.; Rudko, D. A.; Trudeau, L.-E.
10.1101/2024.12.24.630165 — neuroscience — Posted on 2024-12-24
745 Engineering an Exo70 integrated domain of a barley NLR for improved blast resistance
Saado, I.; Brabham, H.; Bennett, J. W.; Lam, A. H. C.; Hernandez-Pinzon, I.; Moscou, M. J.; Concepcion, J. C. D. l.; Banfield, M. J.
10.1101/2024.12.24.630226 — plant biology — Posted on 2024-12-24
747 A Witches' Broom Phytoplasma effector induces stunting by stabilizing a bHLH transcription factor in plants
Yang, S.; Lovelace, A.; Yuan, Y.; Nie, H.; Chen, W.; Gao, Y.; Bo, W. B.; Nagel, D. H.; Pang, X.; Ma, W.
10.1101/2024.12.24.629987 — plant biology — Posted on 2024-12-24
748 Uncovering Ancient DNA in Petroleum: Insights into Earth Hidden Life Events and Geological History
Zhao, W.-Q.; Guo, Z.-Y.; Guo, Y.-Q.; Li, M.-J.; Cao, G.-Q.; Tian, Z.-Y.; Chai, R.; Qiu, L.-Y.; Zeng, J.-H.; Zhang, X.-G.; Qin, T.-C.; Yang, J.-Y.; Chen, M.-J.; Song, M.-R.; Liang, F.; Geng, J.-H.; Zhou, C.-Y.; Zhang, S.-J.; Zhao, L.-J.
10.1101/2024.12.24.630223 — paleontology — Posted on 2024-12-24
749 Single-Cell Temporal Atlas of Myeloid Cells in the Live Haemorrhagic Brain
Kawamura, Y.; Johnson, C.; DeLong, J.; de Lima Camillo, L. P.; Takahashi, M.; Beatty, H. E.; Herbert, R.; Cord, B. J.; Matouk, C.; Askenase, M.; Sansing, L. H.
10.1101/2024.12.24.630187 — bioinformatics — Posted on 2024-12-24
751 Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction
Li, Z.; LaPenna, K.; Gehred, N. D.; Yu, X.; Tang, W. H. W.; Doiron, J. E.; Xia, H.; Chen, J.; Driver, I.; Sachse, F.; Muraoka, N.; Katsouda, A.; Zampas, P.; Haydel, A. G.; Quiriarte, H.; Zagouras, A. A.; Wilcox, J.; Gromova, T.; Shah, S. J.; Goodchild, T. T.; Allerton, T. D.; Jensen, M.; Papapetropoulos, A.; Sharp, T. E.; Vondriska, T. M.; Lefer, D. J.
10.1101/2024.12.20.629549 — physiology — Posted on 2024-12-24
752 YAP engages RIF1 to dampen replication stress in squamous cell carcinoma.
Bojko, J.; Flynn, B.; Howard, A.; Aschenbrenner, B.; Lay, E.; Krajic, N.; Bailey, E.; Catalan, S.; Gallacher, K.; Sins, E.; Wang, J. A.; Jungwirth, U.; Lichtenberger, B. M.; Walko, G.
10.1101/2024.12.20.629444 — cancer biology — Posted on 2024-12-24
755 Correlation between DNA double strand breaks and cell death in peripheral blood lymphocytes from breast cancer patients
Solana-Pena, A.; Pujol-Canadell, M.; Lopez, J.-S.; Macia, M.; Martinez Perez, E.; Linares, I.; Stefanovic, M.; Perez-Montero, H.; Gonzalez-Viguera, J.; Aranguena Penacoba, M.; Ventura, M.; de Miguel-Garcia, G.; Guedea, F.; Erill, N.; Gonzalez-Rumayor, V.; Armengol, G.; Barquinero, J. F.
10.1101/2024.12.23.630130 — cell biology — Posted on 2024-12-24
759 VSIG4-Expressing Macrophages Contribute To Anti-Parasitic And Anti-Metastatic Responses In The Peritoneal Cavity
Van Ginderachter, J. A.; Lebegge, E.; Kancheva, D.; Van Craenenbroeck, J.; Ernst, S.; Bardet, P. M. R.; Caro, A. A.; Kiss, M.; Jumapili, N. A.; Mora Barthelmess, R.; Zivalj, M.; Assaf, N.; Elkrim, Y.; Demuytere, J.; De Jonge, J.; Raes, G.; Hadadi, E.; Devoogdt, N.; Vincke, C.; Vereecke, L.; Ceelen, W.; Stijlemans, B.; Laoui, D.; Arnouk, S. M.
10.1101/2024.12.23.630094 — immunology — Posted on 2024-12-24
760 Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP
Fuchsberger, T.; Stockwell, I.; Woods, M.; Brzosko, Z.; Greger, I. H.; Paulsen, O.
10.1101/2024.06.25.600624 — neuroscience — Posted on 2024-12-24
771 Histone H4 limits transcription of the histone locus in Drosophila
Ahmad, K.; Wooten, M.; Takushi, B. N.; Vidaurre, V.; Chen, X.; Henikoff, S.
10.1101/2024.12.23.630206 — genomics — Posted on 2024-12-24
776 Elastase mediated white matter damage in cerebral small vessel disease: Microglia - neutrophils pas de deux
Dong, C.-Y.; Chen, W.; Li, Q.; Fan, J.; Lan, T.; Dong, W.; Sun, L.; Wang, Y.; Shi, M.; Huang, Y.; Chang, Y.; Wang, N.; Xue, J.; Jiang, L.; Huang, Y.; Pan, Y.; He, W.; Shi, K.; Ma, X.; Wang, Y.; Shi, F.-D.; Verkhratsky, A.; Wang, Y.; Jin, W.-N.
10.1101/2024.12.23.630204 — neuroscience — Posted on 2024-12-24
780 The impact of common variants on gene expression in the human brain: from RNA to protein to schizophrenia risk
Liang, Q.; Jiang, Y.; Shieh, A. W.; Zhou, D.; Chen, R.; Wang, F.; Xu, M.; Niu, M.; Wang, X.; Pinto, D.; Wang, Y.; Cheng, L.; Vadukapuram, R.; Zhang, C.; Grennan, K.; Giase, G.; The PsychENCODE Consortium, ; White, K. P.; Peng, J.; Li, B.; Liu, C.; Chen, C.; Wang, S. H.
10.1101/2023.06.04.543603 — genetics — Posted on 2024-12-24
782 Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin
Isogai, T.; Hirosawa, K. M.; Kanno, M.; Sho, A.; Kasai, R. S.; Komura, N.; Ando, H.; Furukawa, K.; Ohmi, Y.; Furukawa, K.; Yokota, Y.; Suzuki, K. G. N.
10.1101/2024.04.11.589011 — cell biology — Posted on 2024-12-24
783 Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy
Ohno, H.; Nishimura, T.; Kainoh, K.; Ohashi, Y.; Onodera, N.; Kano, M.; Sari, L. N.; Masuda, M.; Tamura, Y.; Hayashi, Y.; Yamamoto, Y.; Takahashi, S.-I.; Mishima, Y.; Yoneyama, Y.; Takeuchi, Y.; Sekiya, M.; Matsuzaka, T.; Miyamoto, T.; Shimano, H.
10.1101/2024.03.01.582671 — cell biology — Posted on 2024-12-24
784 Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells
Elder, E.; Lemieux, A.; Legault, L.-M.; Caron, M.; Bertrand-Lehouillier, V.; Dupas, T.; Raynal, N. J.-M.; Bourque, G.; Sinnett, D.; Gevry, N.; McGraw, S.
10.1101/2024.05.07.592204 — cell biology — Posted on 2024-12-24
785 Uncovering the hidden RNA virus diversity in Lake Nam Co: evolutionary insights from an extreme high-altitude environment
Wu, L.; Liu, Y.; Shi, W.; Chang, T.; Liu, P.; Liu, K.; He, Y.; Li, Z.; Shi, M.; Jiao, N.; Lang, A. S.; Dong, X.; Zheng, Q.
10.1101/2024.07.04.601995 — microbiology — Posted on 2024-12-24
788 Pathological microcircuits initiate epileptiform events in patient hippocampal slices
Elliott, M.; Andrews, J. P.; Molen, T. v. d.; Geng, J.; Spaeth, A.; Toledo, A.; Voitiuk, K.; Core, C.; Gillespie, T.; Sinervo, A.; Parks, D. F.; Robbins, A.; Solis, D.; Chang, E. F.; Nowakowski, T. J.; Teodorescu, M.; Haussler, D.; Sharf, T.
10.1101/2024.11.13.623525 — neuroscience — Posted on 2024-12-24
790 Contralesional hippocampal spreading depolarization promotes functional recovery after stroke
Boyce, A. K.; Fouad, Y.; Gom, R. C.; Ashby, D. M.; Martins-Silva, C.; Molina, L.; Fuzesi, T.; Ens, C.; Nicola, W.; McGirr, A.; Teskey, G. C.; Thompson, R. J.
10.1101/2023.08.31.555814 — neuroscience — Posted on 2024-12-24
791 Neural signatures of opioid-induced risk-taking behavior in the prelimbic prefrontal cortex
Quave, C. B.; Vasquez, A. M.; Aquino-Miranda, G.; Marin, M.; Bora, E. P.; Chidomere, C. L.; Zhang, X. O.; Engelke, D. S.; Do-Monte, F. H.
10.1101/2024.02.05.578828 — neuroscience — Posted on 2024-12-24
792 Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human
Lloyd-Davies Sanchez, D. J.; Lindhout, F.; Anderson, A. J.; Pellegrini, L.; Lancaster, M. A.
10.1101/2024.12.21.629881 — neuroscience — Posted on 2024-12-24
793 The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells
Pan, C.; Liu, Y.; Wang, L.; Fan, W.; Ni, Y.; Zhang, X.; Wu, D.; Li, C.; Li, J.; Li, Z.; Liu, R.; Hu, C.
10.1101/2024.03.11.584397 — physiology — Posted on 2024-12-24
794 Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment
Zhao, W.; Guo, Z.; Tian, Z.; Su, T.; Cao, G.; Qi, Z.; Qin, T.; Zhou, W.; Yang, J.; Chen, M.; Zhang, X.; Zhou, C.; Zhu, C.; Tang, M.; Tang, M.; Wu, D.; Song, M.; Guo, Y.; Qiu, L.; Liang, F.; Li, M.-J.; Geng, J.-H.; Zhao, L.-J.; Zhang, S.-J.
10.1101/2023.06.18.545504 — paleontology — Posted on 2024-12-24
795 CDK8/19 Inhibition Attenuates G1 Arrest Induced by BCR-ABL Antagonists and Accelerates Death of Chronic Myelogenous Leukemia Cells
Khamidullina, A. I.; Yastrebova, M. A.; Bruter, A. V.; Nuzhina, J. V.; Vorobyeva, N. E.; Khrustaleva, A. M.; Varlamova, E. A.; Tyakht, A. V.; Abramenko, Y. E.; Ivanova, E. S.; Zamkova, M. A.; Li, J.; Lim, C.-U.; Chen, M.; Broude, E. V.; Roninson, I. B.; Shtil, A. A.; Tatarskiy, V. V.
10.1101/2023.09.25.559286 — cancer biology — Posted on 2024-12-23
796 Covalent inhibitors of the RAS binding domain of PI3Ka impair tumor growth driven by RAS and HER2
Klebba, J. E.; Roy, N.; Bernard, S. M.; Grabow, S.; Hoffman, M. A.; Miao, H.; Tamiya, J.; Wang, J.; Berry, C.; Esparza-Oros, A.; Lin, R.; Liu, Y.; Pariollaud, M.; Parker, H.; Mochalkin, I.; Rana, S.; Snead, A. N.; Walton, E. J.; Wyrick, T. E.; Aitichson, E.; Bedke, K.; Brannon, J. C.; Chick, J. M.; Hee, K.; Horning, B. D.; Ismail, M.; Lamb, K. N.; Lin, W.; Metzger, J.; Pastuszka, M. K.; Pollock, J.; Sigler, J. J.; Tomaschko, M.; Tran, E.; Kinsella, T. M.; Molina-Arcas, M.; Simon, G. M.; Weinstein, D. S.; Downward, J.; Patricelli, M. P.
10.1101/2024.12.17.629001 — cancer biology — Posted on 2024-12-24
797 Eco-evolutionary Guided Pathomic Analysis to Predict DCIS Upstaging
Xiao, Y.; Elmasry, M.; Bai, J.; Chen, A.; Chen, Y.; Jackson, B.; Johnson, J. O.; Gillies, R. J.; Prasanna, P.; Chen, C.; Damaghi, M.
10.1101/2024.06.23.600274 — cancer biology — Posted on 2024-12-24
798 Lipid Bilayer Strengthens the Cooperative Network of Membrane Proteins
Muhammednazaar, S.; Yao, J.; Nicelis, M. R.; Park, Y. C.; Shen, Z.; Bridges, M. D.; Guo, R.; Swope, N.; Rhee, M. S.; Kim, M.; Kim, K. H.; Hubbell, W. L.; Fleming, K. G.; Columbus, L.; Kang, S.-g.; Hong, H.
10.1101/2023.05.30.542905 — biophysics — Posted on 2024-12-24
799 Activation mechanism of Small Heat Shock Protein HSPB5 revealed by disease-associated mutants.
Woods, C. N.; Janowska, M. K.; Ulmer, L. D.; Sidhu, J. K.; Stone, N. L.; James, E. I.; Guttman, M.; Bush, M. F.; Klevit, R. E.
10.1101/2022.05.30.493970 — biophysics — Posted on 2024-12-24
800 End-to-end neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets
Levy, A.; Raghu, R.; Feathers, J. R.; Grzadkowski, M.; Poitevin, F.; Vallese, F.; Clarke, O. B.; Wetzstein, G.; Zhong, E. D.
10.1101/2024.05.30.596729 — biophysics — Posted on 2024-12-24
802 Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer
Marteau, V.; Nemati, N.; Handler, K.; Raju, D.; Kvalem Soto, E.; Fotakis, G.; Carollo, S.; Boeck, N.; Rossi, A.; Kirchmair, A.; Scheiber, A.; Ammann, A.; Seeber, A.; Gasser, E.; Ormanns, S.; Guenther, M.; Martowicz, A.; Loncova, Z.; Lamberti, G.; Eling, M. T.; Horvath, L.; Fazilaty, H.; Valenta, T.; Sturm, G.; Rieder, D.; Sopper, S.; Pircher, A.; Stoitzner, P.; Ziegler, P.; Tschurtschenthaler, M.; Huemer, F.; Neureiter, D.; Greil, R.; Weiss, L.; Ijsselsteijn, M.; de Miranda, N. F. C. C.; Wolf, D.; Arnold, I. C.; Salcher, S.; Trajanoski, Z.
10.1101/2024.08.26.609563 — bioinformatics — Posted on 2024-12-24
803 Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression
Mantes, A. D.; Herrera, A.; Khven, I.; Schlaeppi, A.; Kyriacou, E.; Tsissios, G.; Skoufa, E.; Santangeli, L.; Buglakova, E.; Durmus, E. B.; Manley, S.; Kreshuk, A.; Arendt, D.; Aztekin, C.; Ligner, J.; La Manno, G.; Weigert, M.
10.1101/2024.02.01.578426 — bioinformatics — Posted on 2024-12-24
806 Sex-dependent influence of major histocompatibility complex diversity on fitness in a social mammal
Schubert, N.; Nichols, H. J.; Mwanguhya, F.; Businge, R.; Kyambulima, S.; Mwesige, K.; Hoffman, J. I.; Cant, M. A.; Winternitz, J. C.
10.1101/2024.12.18.629201 — evolutionary biology — Posted on 2024-12-24
808 Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin (ttn.2) Variants
Santiago, C. F.; Huttner, I. G.; O Brien, A.; Bennett, P. M.; Cvetkovska, J.; Chand, R.; Holt, M.; Trivedi, G.; Wang, L. W.; Smith, K. A.; Gautel, M.; Fatkin, D.; Hinits, Y.
10.1101/2024.12.20.629850 — cell biology — Posted on 2024-12-23
809 Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.
Coakley, A. J.; Hruby, A.; Wang, J.; Bong, A.; Nair, T.; Ramos, C. M.; Alcala, A.; Hicks, D.; Averbukh, M.; Dutta, N.; Moaddeli, D.; Siebrand, C.; de los Rios Rogers, M.; Sahay, A.; Curran, S. P.; Mullen, P. J.; Benayoun, B. A.; Garcia, G.; Higuchi-Sanabria, R.
10.1101/2024.05.27.595950 — cell biology — Posted on 2024-12-24
812 Specific pre-plasma cell states and local proliferation at the dark zone - medulla interface characterize germinal center-derived plasma cell differentiation in lymph node
Binet, L.; Dong, C.; Attaf, N.; Gil, L.; Fallet, M.; Boudier, T.; Escaliere, B.; Chasson, L.; Siret, C.; van de Pavert, S. A.; Navarro, J.-M.; Milpied, P.
10.1101/2024.07.26.605240 — immunology — Posted on 2024-12-23
814 Restoring Oscillatory Dynamics in Alzheimer's Disease: A Laminar Whole-Brain Model of Serotonergic Psychedelic Effects
Gendra, J. C.; Lopez-Sola, E.; Castaldo, F.; Lleal-Custey, E.; Sanchez-Todo, R.; Vohryzek, J.; Salvador, R.; Andrzejak, R.; Ruffini, G.; Alzheimer's Disease Neuroimaging Initiative,
10.1101/2024.12.15.628565 — neuroscience — Posted on 2024-12-23
817 Enteric glia regulate Paneth cell secretion and intestinal microbial ecology
Prochera, A.; Muppirala, A. N.; Kuziel, G. A.; Soualhi, S.; Shepherd, A.; Sun, L.; Issac, B.; Rosenberg, H. J.; Karim, F.; Perez, K.; Smith, K. H.; Archibald, T. H.; Rakoff-Nahoum, S.; Hagen, S. J.; Rao, M.
10.1101/2024.04.15.589545 — neuroscience — Posted on 2024-12-24
819 Non-ionotropic signaling through the NMDA receptor GluN2B carboxy terminal domain drives morphological plasticity of dendritic spines and reverses fragile X phenotypes in mouse hippocampus
Barnes, S. A.; Thomazeau, A.; Finnie, P. S. B.; Heinrich, M. J.; Heynen, A. J.; Komiyama, N.; Grant, S. G. N.; Menniti, F. S.; Osterweil, E. K.; Bear, M. F.
10.1101/2024.12.15.628559 — neuroscience — Posted on 2024-12-24
820 Deep Learning Reveals How Cells Pull, Buckle, and Navigate Tissue-Like Environments
Padhi, A.; Daw, A.; Sawhney, M.; Talukder, M. M.; Agashe, A.; Genin, G. M.; Alisafaei, F.; Kale, S.; Karpatne, A.; Nain, A.
10.1101/2022.10.24.513423 — biophysics — Posted on 2024-12-23
821 Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment: who infects whom?
Landeryou, T.; Maddren, R.; Hearn, J.; Belachew, M.; Rayment-Gomez, S.; Firdawek, E.; Forbes, K.; Mengistu, B.; Lawton, S.; Eze, J.; Tasew, G.; Anjulo, U.; Anderson, R. M.
10.1101/2024.12.20.629811 — genomics — Posted on 2024-12-23
823 PAX2 is Transcriptionally Silenced by a Distinct Mechanism of Epigenetic Reprogramming to Initiate Endometrial Carcinogenesis
Sahoo, S. S.; Ramanand, S. G.; Cuevas, I. C.; Gao, Y.; Lee, S.; Abbas, A.; Zhang, X.; Kumar, A.; Koduru, P.; Roy, S.; Broaddus, R. R.; Bae-Jump, V. L.; Gladden, A. B.; Lea, J.; Lucas, E.; Xing, C.; Kobayashi, A.; Mani, R. S.; Castrillon, D. H.
10.1101/2024.12.23.630121 — cancer biology — Posted on 2024-12-23
824 Single-cell Organelle Extraction with Cellular Indexing
Lam, T.; Su, A.; Gomez Martinez, A. E.; Fomitcheva-Khartchenko, A.; Herr, A. E.
10.1101/2024.12.23.630180 — bioengineering — Posted on 2024-12-23
826 A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function
Gelles, J. D.; Chen, Y.; Luna-Vargas, M. P. A.; Viacava Follis, A.; Bayiokos, S. G.; Mohammed, J. N.; Sebastian, T. M.; Al Noman, M. A.; Pham, N. D.; Shi, Y.; Kriwacki, R. W.; Chipuk, J. E.
10.1101/2024.12.23.630122 — cell biology — Posted on 2024-12-23
829 Structural and functional characterization of the KHNYN extended-diKH domain for mediating ZAP antiviral activity
Youle, R. L.; Lista, M. J.; Bouton, C.; Kunzelmann, S.; Wilson, H.; Cottee, M. A.; Purkiss, A. G.; Morris, E. R.; Neil, S. J.; Taylor, I. A.; Swanson, C. M.
10.1101/2024.12.23.630104 — microbiology — Posted on 2024-12-23
831 Type I interferons induced upon respiratory viral infection impair lung metastatic initiation
Farias, A.; Bridgeman, V.; Rodrigues, F.; Owen, A.; Ruhland, S.; Ferreira, R.; Mack, M.; Malanchi, I.; Johansson, C.
10.1101/2024.12.23.630113 — immunology — Posted on 2024-12-23
832 Spatiotemporal dynamics of EEG microstate networks over the first two years of life: A multi-cohort longitudinal study
Ghosh, P.; Donald, K.; Polanczyk, G. V.; Rodriguez, J. P.; Team, G. P.; Team, K. P.; Working Group, E.; Shephard, E.; Gabard-Durnam, L.
10.1101/2024.12.23.630142 — neuroscience — Posted on 2024-12-23
834 The CoREST-complex regulates MYC stability and promotes post-transcriptional mRNA splicing in melanoma
Ryu, B.; Khan, A. A.; Aptekmann, A. A.; Byun, J.; Min, D.; Povelaitis, M. C.; Shin, J.; Zakrzewski, J. L.
10.1101/2024.12.23.630174 — cancer biology — Posted on 2024-12-23
837 Nucleosome Spacing Can Fine-Tune Higher Order Chromatin Assembly
Chen, L.; Maristany, M. J.; Farr, S. E.; Luo, J.; Gibson, B. A.; Doolittle, L. K.; Rene Espinosa, J.; Huertas, J.; Redding, S.; Collepardo-Guevara, R.; Rosen, M. K.
10.1101/2024.12.23.627571 — biophysics — Posted on 2024-12-23
843 Structure and dynamics of Burkholderia pseudomallei OXA-57, a distinctive low-efficiency class D β-lactamase with carbapenem-hydrolyzing activity
Bragginton, E.; Colenso, C.; Calvopina, K.; Hinchliffe, P.; Shaw, J.; Tooke, C.; Seng, R.; Chantratita, N.; Mulholland, A. J.; Schofield, C.; Spencer, J.
10.1101/2024.12.23.630153 — biochemistry — Posted on 2024-12-23
844 Setdb1 and Atf7IP form a hetero-trimeric complex that blocks Setdb1 nuclear export
Kariapper, L. S.; Marathe, I. A.; Niesman, A. B.; Suino-Powell, K.; Chook, Y. M.; Wysocki, V. H.; Worden, E. J.
10.1101/2024.12.23.630145 — biochemistry — Posted on 2024-12-23
845 Click-linking: a cell-compatible protein crosslinking method based on click chemistry
Amaral, B. C.; Michael, A. R. M.; Brodie, N. I.; Crowder, D. A.; Eiriksson, K. H.; Schriemer, D. C.
10.1101/2024.12.23.630117 — biochemistry — Posted on 2024-12-23
851 LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis
Lewis, R.; Sinigiani, V.; Koos, K.; Bersaglieri, C.; Ashiono, C.; Santoro, R.; Ciaudo, C.; Horvath, P.; Sharma, P.; Kutay, U.
10.1101/2024.12.23.628302 — cell biology — Posted on 2024-12-23
852 Angiotensin II elicits robust calcium oscillations coordinated within juxtaglomerular cell clusters to suppress renin secretion.
Yamaguchi, H.; Guagliardo, N. A.; Smith, J. P.; Xu, F.; Yamaguchi, M.; Almeida, L. F.; Matsuoka, D.; Medrano, S.; Gomez, A. R.; Sequeira-Lopez, M. L. S.
10.1101/2024.12.23.629519 — cell biology — Posted on 2024-12-23
853 The NPxY motifs in the β integrin regulate serotonin response and mechanosensation in C. elegans
Bumm, J. H.; Lee, D. D.; Qiu, Z.; Choi, A. H.; Kiolluri, M.; Olsen, M.; Wang, L.; Lee, M.
10.1101/2024.12.23.630109 — cell biology — Posted on 2024-12-23
854 POLO kinase inhibits Protein Phosphatase 1 to promote the Spindle Assembly Checkpoint and prevent aneuploidy
Moura, M.; Barbosa, J. F.; Pinto, I.; Leca, N.; Cunha-Silva, S.; Verza, A. E.; Pedroso, P. D.; Lemaire, S.; Duro, J.; Silva, M. S.; Oliveira, A.; Reis, R.; Nilsson, J.; Sunkel, C. E.; Musacchio, A.; Bollen, M.; Conde, C.
10.1101/2024.12.23.630043 — cell biology — Posted on 2024-12-23
857 Genetic basis for antimicrobial resistance in Escherichia coli isolated from household water in municipal Ibadan, Nigeria
Akintayo, I. J.; Odeyemi, J. S.; Alabi, O. S.; Mohammed, H. O.; Ikhimiukor, O.; Afolayan, A. O.; Thomson, N.; Okeke, I. N.
10.1101/2024.12.23.630052 — microbiology — Posted on 2024-12-23
858 Expression of Intron-containing HIV-1 RNA Induces NLRP1 Inflammasome Activation in Myeloid Cells
Jalloh, S.; Hughes, I. K.; Akiyama, H.; Gojanovich, A.; Quinones, A.; Yang, M.; Henderson, A. J.; Mostoslavsky, G.; Gummuluru, S.
10.1101/2024.12.23.630103 — microbiology — Posted on 2024-12-23
859 Mammalian ZAP and KHNYN independently restrict CpG-enriched avian viruses
Becker, J. T.; Mickelson, C. K.; Pross, L. M.; Sanders, A. E.; Vogt, E. R.; Shepherd, F. K.; Wick, C.; Barkhymer, A. J.; Aron, S. L.; Fay, E. J.; Harris, R. S.; Langlois, R. A.
10.1101/2024.12.23.629495 — microbiology — Posted on 2024-12-23
860 Actin polymerization by WASp limits nuclear envelope rupture and inflammation in macrophages
Amadio, R.; Bracchetti, G.; Alraies, Z.; Piperno, G. M.; Rodriguez, L. L.; Maurin, M.; Conti, M.; Andolfi, L.; Castiello, M. C.; Ferrua, F.; Villa, A.; Aiuti, A.; Lennon-Dumenil, A.-M.; Benvenuti, F.
10.1101/2024.12.23.630061 — immunology — Posted on 2024-12-23
861 Cytoplasmic expression of the cell cycle regulator cyclin D1 in radial glial progenitor cells modulates brain cortex development
PEDRAZA, N.; Rocandio, D.; Montserrat, M. V.; Zammou, B.; Ortiz-Brugues, A.; Marfull-Oromi, P.; Chauhan, D.; Encinas, M.; Dolcet, X.; Espinet, C.; Ferrezuelo, F.; GARI, E.; Egea, J.
10.1101/2024.12.23.630056 — neuroscience — Posted on 2024-12-23
863 Foveal action for the control of extrafoveal vision
Zhang, T.; Tian, X.; Malevich, T.; Baumann, M. P.; Hafed, Z. M.
10.1101/2024.12.23.630151 — neuroscience — Posted on 2024-12-23
866 Identifying brain-penetrant small molecule modulators of human microglia using a cellular model of synaptic pruning
McCrea, L. M.; Batorsky, R. E.; Bowen, J. J.; Yeh, H.; Thanos, J. M.; Fu, T.; Perlis, R. H.; Sheridan, S. D.
10.1101/2024.12.23.630139 — neuroscience — Posted on 2024-12-23
867 Modeling the emergent metabolic potential of soil microbiomes in Atacama landscapes
Andreani-Gerard, C. M.; Jimenez, N. E.; Palma, R.; Muller, C.; Hamon-Giraud, P.; Le Cunff, Y.; Cambiazo, V.; Gonzalez, M.; Siegel, A.; Frioux, C.; Maass, A.
10.1101/2024.12.23.630026 — systems biology — Posted on 2024-12-23
868 Sporophyte Directed Gametogenesis via the Ubiquitin Proteasome System
Sivakumar, P.; Pandey, S.; Ramesha, A.; Davda, J. N.; Singh, A.; Kumar, C.; Gala, H. P.; Subbiah, V.; Adicherla, H.; Dhawan, J.; Aravind, L.; Siddiqi, I.
10.1101/2024.12.23.630054 — plant biology — Posted on 2024-12-23
869 Circadian PERIOD proteins sculpt themammalian alternative splicing landscape
Chikhaoui, L.; Mamgain, K.; Seki, M.; Blanco, C.; Sassolas, F.; Folco, E.; Sery, D.; Suzuki, Y.; Ananthasubramaniam, B. G.; Padmanabhan, K.
10.1101/2024.12.23.630108 — physiology — Posted on 2024-12-23
870 Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo
Karle, C.; Filosa, D. I.; Akbarpour, M.; Schuhmacher, N.; Brons, S.; Cee, R.; Schoemers, C.; Scheloske, S.; Petersson, K.; Haberer, T.; Abdollahi, A.; Debus, J.; Tessonnier, T.; Moustafa, M.; Mairani, A.; Dokic, I.
10.1101/2024.12.23.630077 — cancer biology — Posted on 2024-12-23
871 Exploring Adenosine Analogues for Chondrosarcoma Therapy: In Vitro and In Vivo Insights
Lente, M.; Aury-Landas, J.; Taieb, M.; Bernay, B.; Lhuissier, E.; Boumediene, K.; BAUGE, C.
10.1101/2024.12.23.630093 — cancer biology — Posted on 2024-12-23
872 Functional specialization of MITF, TFEB and TFE3 drives radically distinct adaptive gene expression programs in melanoma.
Dias, D.; Oliveira, E.; Marti-Diaz, R.; Andrews, S.; Chocarro-Calvo, A.; Bellini, A.; Mosteo-Lopez, L.; Vivas-Garcia, Y.; Chauhan, J.; Li, L.; Garcia-Martinez, J. M.; Rodriguez-Lopez, J. N.; Maria-Engler, S. S.; Garcia-Jimenez, C.; Sanchez-del-Campo, L.; Louphrasitthiphol, P.; Goding, C. R.
10.1101/2024.12.23.629393 — cancer biology — Posted on 2024-12-23
874 Demonstrating Soft X-Ray Tomography in the lab for correlative cryogenic biological imaging using X-rays and light microscopy
O'Connor, S.; Rogers, D.; Kobylynska, M.; Geraets, J.; Thaysen, K.; Egebjerg, J. M.; Brink, M. C.; Herbsleb, L.; Salakova, M.; Fuchs, L.; Alves, F.; Feldmann, C.; Ekman, A.; Sheridan, P.; Fyans, W.; McEnroe, T.; O'Reilly, F.; Fahy, K.; Fleck, R. A.; Wüstner, D.; Simpson, J. C.; Walter, A.; Kapishnikov, S.
10.1101/2024.12.23.629889 — biophysics — Posted on 2024-12-23
877 Confounder-aware foundation modeling for accurate phenotype profiling in cell imaging
Papanastasiou, G.; Sanchez, P.; Christodoulidis, A.; Yang, G.; Pinaya, W. H. L.
10.1101/2024.12.23.630105 — bioengineering — Posted on 2024-12-23
878 Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1
Machner, L.; Shaikhqasem, A.; Gruber, T.; Hamdi, F.; Breithaupt, C.; Kniest, J.; Wiebe, F.; Lewitzky, M.; Parthier, C.; Kyrilis, F. L.; Balbach, J.; Kastritis, P. L.; Feller, S. M.; Stubbs, M. T.
10.1101/2024.12.23.630100 — biochemistry — Posted on 2024-12-23
879 Do-it-yourself de novo antibody sequencing workflow that achieves complete accuracy of the variable regions
He, M.-T.; Li, N.; Wang, J.-H.; Wei, Z.-Z.; Feng, J.; Li, W.-T.; Sui, J.-H.; Huang, N.; Dong, M.-Q.
10.1101/2024.12.23.630060 — biochemistry — Posted on 2024-12-23
886 Circadian regulation of key physiological processes by the RITMO1 clock protein in the marine diatom Phaeodactylum tricornutum
Manzotti, A.; Monteil, R.; Cheminant-Navarro, S.; Croteau, D.; Charreton, L.; Hoguin, A.; Strumpen, N. F.; Jallet, D.; Daboussi, F.; Kroth, P.; Bouget, F.-Y.; Jaubert, M.; Bailleul, B.; Bouly, J.-P.; Falciatore, A.
10.1101/2024.12.23.629939 — molecular biology — Posted on 2024-12-23
890 Cerebral perfusion and metabolic response of astrocytes and neurons during locomotion
Tiaglik, A.; Morozova, K.; Fedotova, A.; Brazhe, A.; Li, L.; Liu, D.; Zhu, L.-Q.; Bilan, D.; Oleinikov, V.; Brazhe, N.; Semyanov, A.
10.1101/2024.12.23.630097 — neuroscience — Posted on 2024-12-23
891 Emergence of Pre-movement Beta Activity with Stable Sensorimotor Predictions to Facilitate Motor Adjustments
Bracco, M.; Vasudevan, V.; Rohira, V.; Welniarz, Q.; Razafinimanana, M.; Richard, A.; Gitton, C.; Meunier, S.; Valero-Cabre, A.; Schwartz, D.; Popa, T.; Gallea, C.
10.1101/2024.12.23.630078 — neuroscience — Posted on 2024-12-23
893 A Comprehensive Assessment of Methylation-Based Age Prediction Methods
Wang, H.; Qu, J.; Zong, Z. X.; Cai, R. R.; Li, K. Y.; Zhao, L. S.; Hai, Q. B.; Tian, T. R.; Kuang, J. Z.; Zhang, L.; Zhao, J.; Liu, X. G.; Zhang, C.
10.1101/2024.12.23.627443 — bioinformatics — Posted on 2024-12-23
895 LEF1-AS1 deregulation in the peripheral blood of patients with persistent post-COVID symptoms
Made, A.; Piella, S. N.; Ranucci, M.; Gaetano, C.; Renna, L. V.; Cardani, R.; Spinetti, G.; Martelli, F.
10.1101/2024.12.20.629131 — molecular biology — Posted on 2024-12-23
896 Antiviral activity of Tecovirimat against Mpox virus clades 1a, 1b, 2a and 2b
Postal, J.; Guivel-Benhassine, F.; Porrot, F.; Grassin, Q.; Crook, J.; Vernuccio, R.; Caro, V.; Vanhomwegen, J.; Guardado-Calvo, P.; Simon-Loriere, E.; Dacheux, L.; Manuguerra, J.-C.; Schwartz, O.
10.1101/2024.12.20.629622 — microbiology — Posted on 2024-12-23
897 Characterization of a heterogenous activated B cell compartment arising early after antigen exposure preceding long-lived memory B cell formation
Fernandez Blanco, L.; Kuijper, L. H.; Kummer, L. Y.; Verstegen, N. J.; Bos, A.; Claireaux, M.; Duurland, M. C.; Jorritsma, T.; Steenhuis, M.; Kerster, G.; Garcia-Vallejo, J. J.; van Gils, M. J.; van Dam, K. P.; Stalman, E. W.; Wieske, L.; Boekel, L.; Wolbink, G.; Tas, S. W.; Rispens, T.; Kuijpers, T. W.; Eftimov, F.; ten Brinke, A.; van Ham, S. M.; On behalf of T2B! Immunity against SARS-CoV-2 study group,
10.1101/2024.12.22.629610 — immunology — Posted on 2024-12-23
900 YAP regulates periosteal expansion in fracture repair
Nijsure, M. P.; Tobin, B. R.; Jones, D.; Lang, A.; Hallstrom, G.; Baitner, M.; Tanner, G. I.; Moharrer, Y.; Panebianco, C. J.; Seidl, E. G.; Dyment, N. A.; Szeto, G. L.; Wood, L. B.; Boerckel, J. D.
10.1101/2024.12.23.630086 — cell biology — Posted on 2024-12-23
901 Critical Scaling of Novelty in the Cortex
Ribeiro, T. L.; Vakili, A.; Gifford, B.; Siddiqui, R.; Sinfuego, V.; Pajevic, S.; Plenz, D.
10.1101/2024.12.23.630084 — neuroscience — Posted on 2024-12-23
903 Investigating the Role of Glyoxalase 1 as a Therapeutic Target for Cocaine and Oxycodone Use Disorder
Alcantara, E.; Doyle, M. R.; Ortez, C. A.; Ilustrisimo, A.; Stromberg, B.; Barkley-Levenson, A. M.; Palmer, A. A.
10.1101/2024.12.23.630123 — neuroscience — Posted on 2024-12-23
910 Methyl-CODEC enables simultaneous methylation and duplex sequencing
Liu, R.; Darbeheshti, F.; Walsh, L.; Li, R.; Bae, J. H.; Zeggar, H. R.; Narayan, A.; Xiong, K.; Makrigiorgos, G. M.; Adalsteinsson, V. A.
10.1101/2024.12.23.630102 — genomics — Posted on 2024-12-23
911 MAPK15 Protects Against The Development Of Metabolic Dysfunction-Associated Steatotic Liver Disease
Inzalaco, G.; Gargiulo, S.; Bonente, D.; Gherardini, L.; Franci, L.; Lorito, N.; Del Turco, S.; Tatoni, D.; Tamborrino, T.; Bertelli, E.; D'Aurizio, R.; Andreassi, M. G.; Basta, G.; Gastaldelli, A.; Morandi, A.; Barone, V.; Chiariello, M.
10.1101/2024.12.23.630083 — cell biology — Posted on 2024-12-23
914 Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins
Proellochs, N. I.; Andolina, C.; Ramjith, J.; Stoter, R.; van Gemert, G.-J.; Graumans, W.; Campino, S.; Vanheer, L. N.; Okitwi, M.; Tumwebaze, P. K.; Conrad, M. D.; Clark, T. G.; Fidock, D. A.; Menard, D.; Mok, S.; Bousema, T.
10.1101/2024.12.23.630038 — microbiology — Posted on 2024-12-23
916 Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4+ T-cells
Herrera, A.; Leyre, L.; Weiler, J.; Linden, N. L.; Huynh, T. T.; Wang, F.; Kovacs, C.; Caskey, M.; Zumbo, P.; Amiama, M. A.; Terry, S.; Ho, Y.-C.; Betel, D.; Jones, R. B.
10.1101/2024.12.22.629960 — immunology — Posted on 2024-12-23
918 A simple ex vivo bladder infection model permits study of host-pathogen interactions in UTI
Koehn, R.-M.; Durand, M.; Ramirez Finn, L.; Costas, A.; Soderstrom, B.; Lacerda Mariano, L.; Ingersoll, M. A.
10.1101/2024.12.23.630047 — immunology — Posted on 2024-12-23
919 Network Segregation During Episodic Memory Shows Age-Invariant Relations with Memory Performance From 7 to 82 Years
Grydeland, H.; Sneve, M. H.; Roe, J. M.; Raud, L.; Ness, H. T.; Folvik, L.; Amlien, I.; Geier, O.; Sorensen, O.; Vidal-Pineiro, D.; Walhovd, K. B.; Fjell, A. M.
10.1101/2024.12.23.630050 — neuroscience — Posted on 2024-12-23
920 A Systematic Comparison of Single-Cell Perturbation Response Prediction Models
Li, L.; You, Y.; Liao, W.; Fan, X.; Lu, S.; Cao, Y.; Li, B.; Ren, W.; Fu, Y.; Kong, J.; Zheng, S.; Chen, J.; Liu, X.; Tian, L.
10.1101/2024.12.23.630036 — bioinformatics — Posted on 2024-12-23
921 Unveiling DNA Origami Interaction Dynamics on Living Cell Surfaces by Single Particle Tracking
Van Zundert, I.; Spezzani, E.; Riera Brillas, R.; Paffen, L. J. M. M.; Yurchenko, A.; de Greef, T. F. A.; Albertazzi, L.; Bertucci, A.; Patino Padial, T.
10.1101/2024.12.23.628980 — bioengineering — Posted on 2024-12-23
922 Introgression and divergence in a young species group
Satokangas, I.; Martin, S. H.; Seifert, B.; Puukko, T.; Helantera, H.; Kulmuni, J.
10.1101/2024.12.23.630027 — evolutionary biology — Posted on 2024-12-23
924 A member of a new dynamin superfamily modulates mitochondrial membrane branching in Trypanosoma brucei
Morel, C. A.; Asencio, C.; Moreira, D.; Blancard, C.; Salin, B.; Gontier, E.; Duvezin-Caubet, S.; Rojo, M.; Bringaud, F.; Tetaud, E.
10.1101/2023.06.28.546890 — microbiology — Posted on 2024-12-23
925 Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C
Pothast, C. R.; Derksen, I.; van der Plas - van Duijn, A.; el Hebieshy, A.; Huisman, W.; Franken, K. L.; Neefjes, J.; Luimstra, J. J.; Griffioen, M.; Kester, M. G.; Vermeer, M. H.; Heemskerk, M. H.; Scheeren, F.
10.1101/2024.12.23.630039 — immunology — Posted on 2024-12-23
926 Integrative multiomics analysis of metabolic dysregulation induced by occupational benzene exposure in mice
Scofield, S.; Koshko, L.; Stilgenbauer, L.; Booms, A.; Berube, R.; Kassotis, C.; Lin, C.-H.; Jang, H.; Kim, S.; Stemmer, P.; Lempradl, A.; Sadagurski, M.
10.1101/2024.12.22.629805 — pharmacology and toxicology — Posted on 2024-12-23
929 Probing mechanical selection in diverse eukaryotic genomes through accurate prediction of 3D DNA mechanics
Park, J.; Prokopchuk, G.; Popchock, A. R.; Hao, J.; Liao, T.-W.; Yan, S.; Hedman, D. J.; Larson, J. D.; Walther, B.; Becker, N. A.; Basu, A.; Maher, L. J.; Wheeler, R. J.; Asbury, C. L.; Biggins, S.; Lukes, J.; Ha, T.
10.1101/2024.12.22.629997 — biophysics — Posted on 2024-12-23
930 FAIRSCAPE: An Evolving AI-readiness Framework for Biomedical Research
Al Manir, S.; Levinson, M. A.; Niestroy, J.; Churas, C.; Parker, J. A.; Clark, T.
10.1101/2024.12.23.629818 — bioinformatics — Posted on 2024-12-23
933 Tryptophan metabolite atlas uncovers organ, age, and sex-specific variations
Perez-Castro, L.; Nawas, A.; Kilgore, J.; Garcia, R.; Lafita-Navarro, M. C.; Acosta, P.; Nogueira, P.; Williams, N.; Conacci Sorrell, M.
10.1101/2024.12.23.630041 — biochemistry — Posted on 2024-12-23
934 A self-limiting Sterile Insect Technique alternative for Ceratitis capitata
Davydova, S.; Liu, J.; Liu, Y.; Prince, K.; Mann, J.; Kandul, N. P.; Braswell, W. E.; Champer, J.; Akbari, O. S.; Meccariello, A.
10.1101/2024.12.23.629662 — genetics — Posted on 2024-12-23
936 Spatiotemporal Regulatory Logics of Mouse Gastrulation
Yang, X.; Xie, B.; Shen, P.; Chen, Y.; Li, C.; Tan, F.; Yang, Y.; Yang, Y.; Song, R.; Mi, P.; Liu, Z.; Wen, M.; Tam, P.; Suo, S.; Jing, N.
10.1101/2024.12.22.630012 — developmental biology — Posted on 2024-12-23
938 Alternative splicing of SORBS1 affects neuromuscular junction formation and stability in myotonic dystrophy type 1
Hermitte, C.; de Calbiac, H.; Moulay, G.; Merien, A.; Laine, J.; Polveche, H.; Cailleret, M.; Vassilopoulos, S.; Kabashi, E.; Furling, D.; Martinat, C.; Gazzola, M.
10.1101/2024.12.23.630072 — molecular biology — Posted on 2024-12-23
939 Characterisation of in vitro resistance selection against second-/last-line antibiotics in methicillin-resistant Staphylococcus aureus
Prasetyoputri, A.; Pitt, M. E.; Cao, M. D.; Ramu, S.; Kavanagh, A.; Elliott, A. G.; Ganesamoorthy, D.; Monk, I.; Stinear, T. P.; Cooper, M. A.; Coin, L. J. M.; Blaskovich, M. A. T.
10.1101/2024.12.22.630013 — microbiology — Posted on 2024-12-23
941 Aggregation promoting sequences rather than phosphorylation are essential for Tau-mediated toxicity in Drosophila
Cooper, A.; Richardson, B.; Ruiz Ortega, E.; Zhang, Y.; Batchelor, B.; Vaikakkara Chithran, A.; Liu, J.; Lian, T.; Ramirez Moreno, M.; Boehme, B.; Abtahi, S.; Devitt, G.; Sivanantharajah, L.; Skoulakis, E. M. C.; Allan, D. W.; Mudher, A.
10.1101/2024.12.22.629946 — neuroscience — Posted on 2024-12-23
943 IFNα Inhibits JAK2V617F-Driven Neoplastic Vasculogenesis and Endothelial-to-Mesenchymal Transition in a 3D iPSC-Based Bone Marrow Niche Model
Caduc, M. J.; Elsafi Mabrouk, M. H.; Lopez, C. B.; Grasshoff, M.; Buhl, E. M.; Ernst, S.; Wong, D. W. L.; Müller-Newen, G.; Vogt, M.; Eschweiler, J.; Boor, P.; Ackermann, M.; Chatain, N.; Franzen, J.; Gesteira Costa Filho, I.; Zenke, M.; K. Schneider, R.; Brümmendorf, T. H.; Koschmieder, S.; de Toledo, M. A. S.
10.1101/2024.12.23.630035 — cancer biology — Posted on 2024-12-23
945 MEANtools: multi-omics integration towards metabolite anticipation and biosynthetic pathway prediction
Singh, K. S.; Suarez Duran, H.; Del Pup, E.; Zafra-Delgado, O.; Van Wees, S. C. M.; van der Hooft, J. J. J.; Medema, M. H.
10.1101/2024.12.22.629970 — bioinformatics — Posted on 2024-12-23
948 Engineered biological neural networks as basic logic operators
Küchler, J.; Vulic, K.; Yao, H.; Valmaggia, C.; Ihle, S. J.; Weaver, S.; Vörös, J.
10.1101/2024.12.23.630065 — neuroscience — Posted on 2024-12-23
952 The colon is an extra-pancreatic source of glucagon: demonstration in a mouse model of pancreatectomy
Jarry, A.-C.; Le Beyec, J.; Bado, A.; Gautier, J.-F.; Riveline, J.-P.; Blondeau, B.; Guillemain, G.; Le Gall, M.
10.1101/2024.12.23.630024 — physiology — Posted on 2024-12-23
954 Regular Plasmodium falciparum importation onto Bioko Island, Equatorial Guinea, hampers malaria elimination from the island
Stabler, T. C.; Dwivedi, A.; Guo, B.; Shrestha, B.; Joshi, S.; Rivas, M. R.; Donfack, O. T.; Guerra, C. A.; Garcia, G.; Daubenberger, C.; Silva, J. C.
10.1101/2024.12.19.629489 — genomics — Posted on 2024-12-23
958 Dynamic p21-dependency during quiescence arrest unveiled by a rapid p21 depletion system
Liang, H.; Zheng, D.; Ai, Z.; Qiu, S.; Song, Y.; Ma, C.; Meng, W.; He, F.; Ma, J.
10.1101/2024.12.23.630045 — cell biology — Posted on 2024-12-23
959 A single cell and spatial genomics atlas of human skin fibroblasts in health and disease
Steele, L.; Admane, C.; Chakala, K. P.; Foster, A.; Gopee, N. H.; Koplev, S.; Mazin, P.; Olabi, B.; Roberts, K.; Tudor, C.; Winheim, E.; Annusver, K.; Correa-Gallegos, D.; Forsthuber, A.; Francis, L.; Frech, S.; Ganier, C.; Layton, T.; Liu, Y.; Yuan, H.; Gudjonsson, J.; Lichtenberger, B. M.; Mahil, S.; Nanchahal, J.; O'Toole, E. A.; Plikus, M.; Rinkevich, Y.; Rognoni, E.; Smith, C.; Teichmann, S. A.; Kasper, M.; Lotfollahi, M.; Haniffa, M.
10.1101/2024.12.23.629194 — cell biology — Posted on 2024-12-23
960 A secreted helminth microRNA suppresses gastrointestinal cell differentiation required for innate immunity
Perez, M. G.; Gillan, V.; Anderson, W.; Gerbe, F.; Herbert, F.; McNeilly, T. N.; Maizels, R. M.; Jay, P.; Devaney, E.; Britton, C.
10.1101/2024.12.20.629722 — microbiology — Posted on 2024-12-23
963 Immune Signatures of SARS-CoV-2 Infection Resolution in Human Lung Tissues
Kenney, D. J.; O'Connell, A. K.; Tseng, A. E.; Turcinovic, J.; Sheahan, M. L.; Nitido, A. D.; Montanaro, P.; Gertje, H. P.; Ericsson, M.; Connor, J. H.; Vrbanac, V.; Crossland, N. A.; Harly, C.; Balazs, A. B.; Douam, F.
10.1101/2024.03.08.583965 — immunology — Posted on 2024-12-23
964 Tumor-associated macrophages enhance tumor innervation and spinal cord repair
Dolci, S.; Mannino, L.; Campanelli, A.; Rossi, E.; Bottani, E.; Ciarpella, F.; Karkossa, I.; Setten, E.; Savino, B.; Pruonto, G.; Piazza, N.; Gianoli, S.; Amenta, A.; Busetto, G.; Pezzotta, A.; Di Chio, M.; Castagna, A.; Martinelli, N.; Barone, I.; Boschi, F.; Doherty, A.; Scupoli, M.; Cavallini, C.; Malpeli, G.; Malik, Z.; Sagripanti, L.; Silani, V.; Cristofori, P.; Scanziani, E.; Sandri, M.; Pistocchi, A.; Bossolasco, P.; Endrizzi, M.; Schubert, K.; Fumagalli, G. F.; Locati, M.; Bifari, F.; Decimo, I.
10.1101/2024.12.19.629374 — neuroscience — Posted on 2024-12-23
965 Disturbed repolarisation-relaxation coupling during acute ischaemia permits systolic mechano-arrhythmogenesis.
Cameron, B. A.; Baumeister, P. A.; Lawen, T.; Rafferty, S.; Taeb, B.; Stoyek, M. R.; Greiner, J.; Uzelac, I.; Fenton, F. H.; Peyronnet, R.; Kohl, P.; Quinn, T. A.
10.1101/2024.12.19.629548 — physiology — Posted on 2024-12-23
967 Development of a novel peripherally acting alpha2A-adrenergic receptor antagonist for anti-diabetic
Hong, F.; Wang, J.; Chen, D.; Wang, Q.; Gan, S.; Ye, F.; Chen, L.; Ren, H.; Zhang, T.; Xie, Y.; Jing, X.; Wang, R.; Xu, Z.; Ren, J.; Shi, C.; Jia, S.; Huang, X.; Xu, X.; Zheng, Y.; Lu, J.; Lin, W.; Dai, J.; Wang, L.; Chen, L.; Tang, C.; Liu, H.; Xu, T.; Xie, X.; Liu, X.-a.; Du, Y.; Nan, F.; Chen, Z.
10.1101/2024.12.17.628818 — pharmacology and toxicology — Posted on 2024-12-23
968 A universal single-cell transcriptomics atlas of human lung decodes multiple pulmonary diseases
Wu, F.; Cai, W.; Tang, H.; Zheng, S.; Zhang, H.; Chen, Y.; Han, Y.; Zhou, D.; Wang, R.; Ye, M.; You, R.; Chen, A.; Li, J.; Zhang, X.; Li, W.
10.1101/2024.12.17.628654 — bioinformatics — Posted on 2024-12-23
969 Sparse neural networks enable low-power, implantable neural interfaces
Costello, J. T.; Temmar, H.; Cubillos, L.; Mender, M. J.; Wallace, D. M.; Kelberman, M.; Benharush, O.; Simons, J.; Willsey, M. S.; Ganesh Kumar, N.; Kung, T. A.; Patil, P. G.; Chestek, C. A.
10.1101/2024.12.17.628936 — bioengineering — Posted on 2024-12-23
970 Size-dependent temporal decoupling of morphogenesis and transcriptional programs in gastruloids
Bennabi, I.; Hansen, P.; Merle, M.; Pineau, J.; Lopez-Delisle, L.; Kolly, d.; Duboule, D.; Mayran, A.; Gregor, T.
10.1101/2024.12.23.630037 — developmental biology — Posted on 2024-12-23
971 Microthrombi-growth in ADAMTS13 deficiency exacerbated ulcerative colitis via mucosal and endothelial dysfunction
Tatsuta, K.; Honkura, N.; Morooka, N.; Sakata, M.; Kurachi, K.; Sugimoto, K.; Kokame, K.; Takeuchi, H.; Urano, T.; Suzuki, Y.
10.1101/2024.12.10.627861 — physiology — Posted on 2024-12-23
975 WITHDRAWN: Two distinct structural variants involving EDN3 cause hyperpigmentation in chicken
Ma, C.; Huang, X.-H.; Wang, F.-J.; Zhang, S.-R.; Shi, X.; Weng, Z.-X.; Du, B.; Zhang, Y.-p.; Andersson, L.; Peng, M.-S.
10.1101/2024.12.04.626589 — genomics — Posted on 2024-12-23
977 Black flying foxes in Australia harbor novel Borrelia lineages adjacent to zoonotic clades
Verrett, T. B.; Falvo, C.; Benson, E.; Jones-Slobodian, D. N.; Crowley, D. E.; Dale, A. S.; Lunn, T. J.; Ruiz-Aravena, M.; Bat One Health, ; McKee, C. D.; Clark, K. L.; Peel, A. J.; Plowright, R. K.; Becker, D.
10.1101/2024.12.20.629695 — evolutionary biology — Posted on 2024-12-23
979 Circumferential actomyosin bundles drive endothelial cell deformations to constrict blood vessels
Chen, Y.; Taberner, N.; da Silva, J.; Kondrychyn, I.; Aswani, N.; Chen, G.; Okada, Y.; Lagendijk, A. K.; Okuda, S.; Phng, L.-K.
10.1101/2024.12.22.630001 — cell biology — Posted on 2024-12-23
982 Navigating the Maze: Identifying Potential Pitfalls in Attention State Classification from fMRI Brain Patterns
Bressler, R. A.; Ciarlo, A.; Raible, S.; Valente, G.; Lührs, M.; Tier, R.; Linden, D. E.; Goebel, R.
10.1101/2024.12.20.629827 — neuroscience — Posted on 2024-12-23
983 FGF21 Analogue PF-05231023 on Alcohol Consumption and Neuronal Activity in the Nucleus Accumbens
Cooley, B. J.; Occelli Hanbury-Brown, C. V.; Choi, E. A.; Heller, W. A.; Lim, A. W.; Lawrence, A. J.; Haber, P. S.; McNally, G. P.; Millan, E. Z.
10.1101/2024.12.22.629996 — neuroscience — Posted on 2024-12-23
984 In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors
Zheng, Y.; Cai, R.; Wang, K.; Zhang, J.; Zhuo, Y.; Dong, H.; Zhang, Y.; Wang, Y.; Deng, F.; Ji, E.; Cui, Y.; Fang, S.; Zhang, X.; zhang, k.; Wang, J.; Li, G.; Miao, X.; Wang, Z.; Yang, Y.; Li, S.; Grimm, J.; Johnsson, K.; Schreiter, E. R.; Lavis, L.; Chen, Z.; Mu, Y.; Li, Y.
10.1101/2024.12.22.629999 — neuroscience — Posted on 2024-12-23
985 Association of Bile Acids with Connectivity of Executive Control and Default Mode Networks in Patients with Major Depression
Dunlop, B.; Cha, J.; Mayberg, H. S.; Choi, K. S.; Craighead, W. E.; Mahmoudiandehkordi, S.; Bhattacharyya, S.; Rush, A. J.; Kaddurah-Daouk, R.
10.1101/2024.12.20.629637 — neuroscience — Posted on 2024-12-23
986 Protocol for assessing DNA damage levels in vivo in rodent testicular germ cells in the Alkaline Comet Assay
Olsen, A.-K.; Ma, X.; Zheng, C.; Dahl, H.; Dirven, Y.; Boisen, A. M.; Sharma, A.; Eide, D. M.; Brunborg, G.
10.1101/2024.12.22.624648 — pharmacology and toxicology — Posted on 2024-12-23
987 A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition
Riordan, J. D.; Nathanson, T. A.; Varzavand, A.; Hawkins, A. A.; Peplinski, R. M.; Hannan, E. C.; Bibeau, F. A.; Freesmeier, N. J.; Jilek, M. C.; Coma, S.; Pachter, J. A.; Dupuy, A.; Stipp, C. S.
10.1101/2024.12.22.629990 — cancer biology — Posted on 2024-12-23
992 Genomic Characterisation of Group B Streptococcus from Argentina: Insights into Prophage Diversity, Virulence Factors and Antibiotic Resistance Genes
Kovacec, V.; Di Gregorio, S.; Pajon, M.; Basit Khan, U.; Poklepovich, T.; Campos, J.; Crestani, C.; Bentley, S. D.; Jamrozy, D. M.; Mollerach, M.; Bonofiglio, L.
10.1101/2024.12.20.629649 — bioinformatics — Posted on 2024-12-23
993 Cancer Histone Mutations Impact Binding and DNA Repair Processes, Leading to Increased Mutagenesis
Espiritu, D.; Sheng, Y.; Peng, Y.; Ostroverkhova, D.; Li, S.; Landsman, D.; Aristizabal, M. J.; Panchenko, A. R.
10.1101/2024.12.21.629746 — bioinformatics — Posted on 2024-12-23
994 An A-T Hoogsteen base pair in a naked DNA hairpin motif: A Protein-Recognized Conformation
Guseva, S.; Szekely, O.; Geng, A.; Smith, K.; Pratihar, S.; Gu, S.; Al-Hashimi, H. M.
10.1101/2024.12.22.630000 — biochemistry — Posted on 2024-12-23
995 Non-Canonical Cytochrome P450 Enzymes in Nature
Nguy, A. K. L.; Ireland, K. A.; Kayrouz, C. M.; Caceres, J. C.; Greene, B. L.; Davis, K. M.; Seyedsayamdost, M. R.
10.1101/2024.12.22.630014 — biochemistry — Posted on 2024-12-23
996 Banded mongooses discriminate relatedness and MHC diversity in unfamiliar conspecifics
Schubert, N.; Stober, C.; Born, M.; Mwanguhya, F.; Businge, R.; Kyambulima, S.; Mwesige, K.; Cant, M. A.; Nichols, H. J.; Winternitz, J. C.
10.1101/2024.12.22.629965 — animal behavior and cognition — Posted on 2024-12-23
998 Phenotypic divergence and genomic architecture between parallel ecotypes at two different points on the speciation continuum in a marine snail
Raffini, F.; De Jode, A.; Johannesson, K.; Faria, R.; Zagrodzka, Z. B.; Westram, A. M.; Galindo, J.; Rolan-Alvarez, E.; Butlin, R. K.
10.1101/2023.09.21.558824 — evolutionary biology — Posted on 2024-12-23
1000 Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling
Santos, C. C.; Schweizer, N.; Cairrao, F.; Ramirez, J.; Osinalde, N.; Yang, M.; Gaspar, C. J.; Rasheva, V. I.; Hensel, Z.; Adrain, C.; Cordeiro, T. N.; Voigt, F.; Gameiro, P. A.; Mayor, U.; Domingos, P. M.
10.1101/2024.12.22.629979 — cell biology — Posted on 2024-12-23
1001 Restriction on Ku's Inward Translocation Caps Telomere Ends
Mattarocci, S.; Baconnais, S.; Roisne-Hamelin, F.; Pobiega, S.; Alibert, O.; Morin, V.; Deshayes, A.; Veaute, X.; Ropars, V.; Chevreuil, M.; Mehringer, J.; Busso, D.; Mazon, G.; Fernandez Varela, P.; Le Cam, E.; Charbonnier, J.-B.; Cuniasse, P.; Marcand, S.
10.1101/2024.12.22.629684 — molecular biology — Posted on 2024-12-23
1002 A signaling inspired synthetic toolkit for efficient production of tyrosine phosphorylated proteins
Ryan, M. M.; Portelance, R.; Newman, G. F.; Martinez, G.; Shekharan, S.; Wu, A.; Angel, S.; Schaberg, K. E.; Gilmore, P.; Sprung, R.; Townsend, R.; Naegle, K. M.
10.1101/2024.12.22.629992 — molecular biology — Posted on 2024-12-23
1003 Structural maturation of the matrix lattice is not required for HIV-1 particle infectivity
Chen, L.; Hikichi, Y.; Rey, J. S.; Akil, C.; Zhu, Y.; Veler, H.; Shen, Y.; Perilla, J. R.; Freed, E. O.; zhang, p.
10.1101/2024.12.22.629981 — microbiology — Posted on 2024-12-23
1004 Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data.
Dudzic, P.; Chomicz, D.; Bielska, W.; Jaszczyszyn, I.; Zielinski, M.; Janusz, B.; Wrobel, S.; Le Pannerer, M.-M.; Philips, A.; Ponraj, P.; Kumar, S.; Krawczyk, K.
10.1101/2024.12.20.629642 — immunology — Posted on 2024-12-23
1005 Red-shifted GRAB acetylcholine sensors for multiplex imaging in vivo
Xie, S.; Miao, X.; Li, G.; Zheng, Y.; Li, M.; Ji, E.; Wang, J.; Li, S.; Cai, R.; Geng, L.; Feng, J.; Wei, C.; Li, Y.
10.1101/2024.12.22.627112 — neuroscience — Posted on 2024-12-23
1006 Sensory expectations shape neural population dynamics in motor circuits
Michaels, J. A.; Kashefi, M.; Zheng, J.; Codol, O.; Weiler, J.; Kersten, R.; Gribble, P. L.; Diedrichsen, J.; Pruszynski, J. A.
10.1101/2024.12.22.629295 — neuroscience — Posted on 2024-12-23
1008 HYDRA: HYdrogel Dispensing with Robotic Automation for high throughput drug testing
Torchia, E.; Di Sante, M.; Horda, B.; Mihajlovic, M.; Zimmermann, J.; Pezzotti, M.; Cimetta, E.; Gabriele, S.; Auricchio, F.; Lind, J. U.; Enrico, A.; Pasqualini, F. S.
10.1101/2024.12.22.629679 — bioengineering — Posted on 2024-12-23
1010 Chemical Proteomics Identifies Protein Ligands for Monoacylglycerol Lipids
Shanbhag, K.; Mhetre, A.; Saharan, O.; Devarajan, A.; Madhusudhan, M. S.; Chakrapani, H.; Kamat, S. S.
10.1101/2024.12.22.629584 — biochemistry — Posted on 2024-12-23
1011 Molecular analyses of individual variation in honey bee sociability
Traniello, I. M.; Avalos, A.; Gachomba, M. J. M.; Gernat, T.; Chen, Z.; Cash-Ahmed, A. C.; Hamilton, A. R.; Cook, J. L.; Robinson, G. E.
10.1101/2024.12.22.629994 — genomics — Posted on 2024-12-23
1018 A comprehensive analysis of Transcribed Ultra Conserved Regions uncovers important regulatory functions of novel non-coding transcripts in gliomas.
Gibert, M. K.; Zhang, Y.; Saha, S.; Marcinkiewicz, P.; Dube, C.; Hudson, K.; Sun, Y.; Bednarek, S.; Chagari, B.; Sarkar, A.; Roig-Laboy, C.; Neace, N.; Saoud, K.; Setiady, I.; Hanif, F.; Schiff, D.; Kumar, P.; Kefas, B.; Hafner, M.; Abounader, R.
10.1101/2023.09.12.557444 — cancer biology — Posted on 2024-12-22
1021 Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs
Aguirre, C.; Miyanoiri, Y.; So, M.; Tamaki, H.; Maruno, T.; Doi, J.; Wang, N.; Yamaguchi, K.; Nakajima, K.; Yamamori, Y.; Inoura, H.; Choong, C.-J.; Kakuda, K.; Ajiki, T.; Kimura, Y.; Ozono, T.; Baba, K.; Nagano, S.; Nagai, Y.; Ogi, H.; Uchiyama, S.; Matsuki, Y.; TOMII, K.; Goto, Y.; Ikenaka, K.; Mochizuki, H.
10.1101/2022.02.10.479831 — biophysics — Posted on 2024-12-22
1022 Structural underpinning of multi-functionality of TFIIE-related tandem-winged-helix in RNA polymerase III
Wu, J.-S.; Lin, Y.-C.; Wei, Y.-Y.; Lin, H.-H.; Liu, Y.-C.; Chang, J.-W.; Tu, I.-P.; Chen, H.-T.; Chang, W.-H.
10.1101/2024.08.27.609947 — biophysics — Posted on 2024-12-22
1023 Spatial-DC: a robust deep learning-based method for deconvolution of spatial proteomics
Li, Y.; Kong, Q.; Wu, Z.; Xu, Y.; Mao, Y.; Gu, Y.; Wang, X.; Gao, W.; Tian, R.; Yao, J.
10.1101/2024.12.18.629082 — bioinformatics — Posted on 2024-12-22
1024 The Plantae Visualization Platform: a comprehensive web-based tool for the integration, visualization, and analysis of omic data across plant and related species
Santiago, A.; Orduna, L.; Fernandez, J. D.; Vidal, A.; de Martin-Agirre, I.; Lison, P.; Vidal, E.; Navarro-Paya, D.; Matus, J. T.
10.1101/2024.12.19.629382 — bioinformatics — Posted on 2024-12-22
1027 Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch
Hom, W. W.; Aykul, S.; Panagis, L.; Patel, K.; Brydges, S.; Goebel, E. J.; Lydon, K. N.; Lees-Shepard, J. B.; Hatsell, S. J.; Idone, V.; Economides, A. N.
10.1101/2024.01.29.577837 — cell biology — Posted on 2024-12-22
1028 Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells
Elder, E.; Lemieux, A.; Legault, L.-M.; Caron, M.; Bertrand-Lehouillier, V.; Dupas, T.; Raynal, N.; Bourque, G.; Sinnett, D.; Gevry, N.; McGraw, S.
10.1101/2024.05.07.592204 — cell biology — Posted on 2024-12-22
1029 CellSeg3D: self-supervised 3D cellsegmentation for fluorescence microscopy
Achard, C.; Kousi, T.; Frey, M.; Vidal, M.; Paychere, Y.; Hofmann, C.; Iqbal, A.; Hausmann, S. B.; Pages, S.; Mathis, M. W.
10.1101/2024.05.17.594691 — cell biology — Posted on 2024-12-22
1030 The inhibitory effects of Remodelin on murine myoblasts differentiation
Sian, V.; Hentschel, A.; Sarparanta, J.; Roos, A.; Jonson, P. H.; Natraj Gayathri, S.; Mai, A.; Rotili, D.; Altucci, L.; Udd, B.; Savarese, M.; Nebbioso, A.
10.1101/2024.12.19.629326 — cell biology — Posted on 2024-12-22
1032 Sprint interval exercise disrupts mitochondrial ultrastructure driving a unique mitochondrial stress response and remodelling in humans
Botella, J.; Perri, E.; Caruana, N. J.; Lopez-Calcerrada, S.; Brischigliaro, M.; Jamnick, N. A.; Oorschot, V.; Saner, N. J.; Diaz-Lara, J.; Taylor, D. F.; Garnham, A.; Fernandez-Vizarra, E.; Ugalde, C.; Ramm, G.; Stroud, D. A.; Lazarou, M.; Bishop, D. J.
10.1101/2024.12.19.629456 — molecular biology — Posted on 2024-12-22
1033 Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1
Wolf van der Meer, J.; Larue, A.; van der Knaap, J.; Chalkley, G.; Sijm, A.; Beikmohammadi, L.; Kozhevnikova, E. N.; van der Vaart, A.; Tilly, B.; Bezstarosti, K.; Dekkers, D. H. W.; Doff, W. A. S.; van de Wetering-Tieleman, J.; Lanko, K.; Barakat, T. S.; Allertz, T.; van Haren, J.; Demmers, J. A.; Atlasi, Y.; Verrijzer, C. P.
10.1101/2024.08.04.606521 — molecular biology — Posted on 2024-12-22
1035 Diel changes in the expression of a marker gene and candidate genes for intracellular amorphous CaCO3 biomineralization in Microcystis
Bruley, A.; Gaëtan, J.; Gugger, M.; Pancrace, C.; Millet, M.; Gaschignard, G.; Dezi, M.; Humbert, J.-F.; Leloup, J.; Skouri-Panet, F.; Callebaut, I.; Benzerara, K.; Duprat, E.
10.1101/2024.07.07.602159 — microbiology — Posted on 2024-12-22
1037 Altered B Cell Metabolic Pathways Characterize Type 1 Diabetes Progression
Conway, H.; Perez, D.; Swar-Eldahab, M.; Pignanelli, J.; Evans-Molina, C.; Felton, J. L.
10.1101/2024.07.03.601778 — immunology — Posted on 2024-12-22
1038 T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts
DeBerg, H. A.; Fahning, M. L.; Varkhande, S. R.; Schlenker, J. D.; Schmitt, W. P.; Gupta, A.; Singh, A.; Gratz, I. K.; Carlin, J. S.; Campbell, D. J.; Morawski, P. A.
10.1101/2024.07.31.606077 — immunology — Posted on 2024-12-22
1040 Nanoporous Platinum Microelectrode Arrays for Neuroscience Applications
Winter-Hjelm, N.; Isdal, L.; Kollensperger, P.; Sandvig, A.; Sandvig, I.; Sikorski, P.
10.1101/2024.06.06.597813 — neuroscience — Posted on 2024-12-22
1043 Millisecond-scale motor coding precedes sensorimotor learning in songbirds
Pascual, L. M.; Vusirikala, A.; Nemenman, I.; Sober, S. J.; Pasek, M. J.
10.1101/2024.09.27.615500 — neuroscience — Posted on 2024-12-22
1044 System genomics of salinity stress response in rice
Gupta, S.; Niels Groen, S.; Zaidem, M. L.; Sajise, A. G. C.; Calic, I.; Natividad, M.; McNally, K.; Vergara, G. V.; Satija, R.; Franks, S. J.; Singh, R. K.; Joly-Lopez, Z.; Purugganan, M. D.
10.1101/2024.05.31.596807 — systems biology — Posted on 2024-12-22
1045 Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophage
Rozum, J. C.; Sineath, W. D.; Kim, D. N.; Bohutskyi, P.; Johnson, C. G.; Evans, J. E.; Pollock, D. D.; Qian, W.-J.; Cheung, M. S.; Wu, R.; Feng, S.
10.1101/2024.12.11.628001 — systems biology — Posted on 2024-12-22
1046 Pregnancy and postpartum dynamics revealed by millions of lab tests
Bar, A.; Moran, R.; Mayo, A.; Mendelson Cohen, N.; Korem Kohanim, Y.; Toledano, Y.; Alon, U.
10.1101/2023.05.11.540359 — physiology — Posted on 2024-12-22
1047 Rapamycin Reduces Arterial Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification
Behzadi, P.; Cuevas, R. A.; Crane, A.; Wendling, A. A.; Chu, C. C.; Moorhead, W. J.; Wong, R.; Brown, M.; Tamakloe, J.; Suresh, S.; Saleh, P.; Jaffe, I. A.; Kuipers, A. L.; Lukashova, L.; Verdelis, K.; St. Hilaire, C.
10.1101/2024.08.01.606196 — physiology — Posted on 2024-12-22
1048 Polyglutamine expansion induced dynamic misfolding of Androgen Receptor
Heling, L. W. H. J.; Sheikhhassani, V.; Ng, J.; van Vliet, M.; Jimenez, A.; Alegre-Marti, A.; Woodard, J.; van Roon-Mom, W.; McEwan, I. J.; Estebanez-Perpina, E.; Mashaghi, A.
10.1101/2024.12.19.629423 — pathology — Posted on 2024-12-22
1049 Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice
Yang, M.; Hussain, H. M. J.; Khan, M.; Muhammad, Z.; Zhou, J.; Ma, A.; Huang, X.; Ye, J.; Chen, M.; Zhi, A.; Liu, T.; Khan, R.; Asim, A.; Shah, W.; Zeb, A.; Ahmad, N.; Zhang, H.; Xu, B.; Ma, H.; Shi, Q.; Shi, B.
10.1101/2024.06.20.599934 — genetics — Posted on 2024-12-22
1050 Skeletal trait measurements for thousands of bird species
Weeks, B. C.; Zhou, Z.; Probst, C. M.; Berv, J. S.; O'Brien, B. K.; Benz, B. W.; Skeen, H. R.; Ziebell, M.; Bodt, L.; Fouhey, D. F.
10.1101/2024.12.19.629481 — evolutionary biology — Posted on 2024-12-22
1054 The IQGAP1-Claudin Cell Junction Axis in Cisplatin-induced Kidney Damage
Barudi, Y.; Fan, X.; Jenkins, K. W.; Dey, S. K.; Yakirevich, E.; Osman, M. A.
10.1101/2024.12.21.629915 — cell biology — Posted on 2024-12-22
1055 Location-Dependent Differences in Cardiac and Skeletal Muscle Dysfunction Associated With Truncating Titin (ttn.2) Variants
Hinits, Y.; O Brien, A.; Huttner, I. G.; Santiago, C. F.; Chand, R.; Bennett, P. M.; Fatkin, D.; Gautel, M.; Wang, L. W.; Trivedi, G.; Smith, K. A.; Cvetkovska, J.; Holt, M.
10.1101/2024.12.20.629850 — cell biology — Posted on 2024-12-22
1057 Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4+ T-cells
Herrera, A.; Leyre, L.; Weiler, J.; Linden, N. L.; Huynh, T. T.; Wang, F.; Kovacs, C.; Caskey, M.; Zumbo, P.; Amiama, M. A.; Terry, S.; Ho, Y.-C.; Betel, D.; Jones, R. B.
10.1101/2024.12.22.629960 — immunology — Posted on 2024-12-22
1059 Phosphotyrosine Signal Profiling of Clinical CAR-T Reveals Tonic Signaling Associated with Therapeutic Efficacy
Yao, B.; Ye, X.; Kong, Q.; Chen, W.; Li, W.; Feng, C.; He, A.; Li, G.; Chen, L.; Chen, X.; Hu, L.; Xie, L.; Qiu, X.; Wang, X.; Lin, Y.; Cao, Y.; Zhou, J.; Zhang, X.; Wang, H.; Tian, R.
10.1101/2024.12.22.629940 — immunology — Posted on 2024-12-22
1060 Genomic Specificity of Anti-TCR mAbs determined by single-cell RNAseq
Magill, I.; Piekarsa, V.; Kossida, S.; Croteau, J.; Lee, A.; Balderas, R.; Zemmour, D.; Benoist, C.
10.1101/2024.12.20.629462 — immunology — Posted on 2024-12-22
1062 Protein aggregation capture assisted profiling of the thiol redox proteome
Martinez-Val, A.; Lozano-Juarez, S.; Lumbreras, J.; Rodriguez, I.; Couselo-Seijas, M.; Simon-Chica, A.; Galan-Arriola, C.; Fernandez, R.; Nunez, E.; Jorge, I.; Filgueiras-Rama, D.; Ibanez, B.; Vaquez, J.
10.1101/2024.12.21.629874 — systems biology — Posted on 2024-12-22
1063 LINC00599 Promotes Pulmonary Hypertension via LLPS with G3BP1 and MYH9
Wang, Y.; Yin, L.; Zheng, S.; Liu, A.; Liu, C.; Bao, Z.; Zhu, H.; Zhao, X.; Zhao, Z.; Pan, Y.; Zhu, D.; Yu, H.
10.1101/2024.12.20.629439 — physiology — Posted on 2024-12-22
1064 Translation Initiation Represents an Acute Myeloid Leukemia Cell Vulnerability That Can Be Co-Targeted With BCL-2 Inhibition
Lee, Y. S.; Good, J. D.; Awais, N.; Eschle, B. K.; Lineberry, M. S.; Teo, J. L.; Bibeau, S.; Wollman, M.; Karadimov, G.; Sariipek, N.; Acosta, J.; Noel, J.; Cucchi, D.; DePasquale, E. A. K.; Gokhale, P. C.; Najm, F. J.; Stone, R. M.; Garcia, J. S.; Lane, A. A.; van Galen, P.
10.1101/2024.12.20.629809 — cancer biology — Posted on 2024-12-22
1065 Role of the NHE1 exchanger in the antitumor effects of copper(II) complexes and phenanthroline derivatives
Munoz Garzon, K. S.; Martinez, V.; de Giusti, V.; Perez Visnuk, D.; Villaverde, M.; Alvarez, N.; Facchin, G.; Di Virgilio, A. L.
10.1101/2024.12.21.629901 — cancer biology — Posted on 2024-12-22
1066 A deep-learning tool for species-agnostic integration of cancer cell states
Rub, J.; Chan, J. E.; Sussman, C.; Tap, W. D.; Singer, S.; Tammela, T.; Betel, D.
10.1101/2024.12.20.629285 — cancer biology — Posted on 2024-12-22
1067 Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling
Wierbilowicz, K.; Yang, C.; Almaghasilah, A.; Wesolowski, P. A.; Pracht, P.; Dworak, N. M.; Masur, J.; Wijngaarden, S.; Filippov, D. V.; Wales, D. J.; Kelley, J. B.; Ratan, A.; Paschal, B. M.
10.1101/2024.12.21.629908 — cancer biology — Posted on 2024-12-22
1068 Combined inhibition of SHP2 overcomes adaptive resistance to type 1 BRAF inhibitors in BRAF V600E-driven high-grade glioma
Ayanlaja, A. A.; Chang, M.; Lalwani, K.; Ioannou, M.; Wang, J.; Jagtap, S.; Yang, Y.; Gartrell, R. D.; Pratilas, C. A.; Schreck, K. C.
10.1101/2024.12.21.629454 — cancer biology — Posted on 2024-12-22
1069 The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability
Perez, A. L.; Zamora, M.; Bahena, M. M.; Aramburo-Williams, R. M.; Adan-Castro, E. M.; Bertsch, T.; Triebel, J.; Martinez de la Escalera, G. M.; Robles, J. P. M.; Clapp, C.
10.1101/2024.12.22.629954 — cancer biology — Posted on 2024-12-22
1075 A single main-chain hydrogen bond required to keep GABAA receptors closed
Borghese, C. M.; Galpin, J. D.; Lidbrink, S. E.; Zhuang, Y.; Desai, N. G.; Howard, R. J.; Lindahl, E.; Ahern, C. A.; Goldschen-Ohm, M. P.
10.1101/2024.12.22.629966 — biophysics — Posted on 2024-12-22
1077 A Palette of Bridged Bicycle-Strengthened Fluorophores
Zhang, J.; Zhang, K.; Wang, K.; Wang, B.; Zhu, S.; Qian, H.; Ma, Y.; Zhang, M.; Liu, T.; Chen, P.; Shen, Y.; Fu, Y.; Fang, S.; Zhang, X.; Zou, P.; Deng, W.; Mu, Y.; Chen, Z.
10.1101/2024.12.20.629585 — biophysics — Posted on 2024-12-22
1080 Genetic ancestry and population structure in the All of Us Research Program cohort
Sharma, S.; Nagar, S. D.; Pemu, P.; Zuchner, S.; SEEC Consortium, ; Marino-Ramirez, L.; Meller, R.; Jordan, I. K.
10.1101/2024.12.21.629909 — bioinformatics — Posted on 2024-12-22
1083 Acoustic tumor paint for real-time imaging, surgical guidance and recurrence monitoring of brain tumors with ultrasound
Rabut, C.; Daghlian, G. H.; Barturen-Larrea, P.; Li, H. R.; Vorder Bruegge, R.; Jones, R. M.; Malounda, D.; Pinton, G. F.; Shapiro, M. G.
10.1101/2024.12.22.629782 — bioengineering — Posted on 2024-12-22
1085 Protein CREATE enables closed-loop design of de novo synthetic protein binders
Lourenco, A. L.; Subramanian, A. M.; Spencer, R. K.; Miao, J.; Anaya, M.; Fu, W.; Chow, E. D.; Thomson, M.
10.1101/2024.12.20.629847 — bioengineering — Posted on 2024-12-22
1086 Xolography for Biomedical Applications: Dual-color Light-sheet Printing of Hydrogels with Local Control over Shape and Stiffness
Stoecker, L.; Cedillo-Servin, G.; Konig, N.; de Graaf, F.; Jimenez, M. G.; Hofmann, S.; Ito, K.; Wentzel, A.; Castilho, M.
10.1101/2024.12.21.629893 — bioengineering — Posted on 2024-12-22
1087 Structural Insights into the Activation and Inhibition of the ADAM17-iRhom2 Complex
Maciag, J. J.; Slone, C.; Alnajjar, H. F.; Rich, M. F.; Guion, B.; Blobel, C. P.; Seegar, T. C.
10.1101/2024.12.22.629961 — biochemistry — Posted on 2024-12-22
1089 Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment: who infects whom?
Landeryou, T.; Maddren, R.; Hearn, J.; Belachew, M.; Rayment-Gomez, S.; Firdawek, E.; Forbes, K.; Mengistu, B.; Lawton, S.; Eze, J.; Tasew, G.; Anjulo, U.; Anderson, R. M.
10.1101/2024.12.20.629811 — genomics — Posted on 2024-12-22
1090 SenSet, a novel human lung senescence cell gene signature, identifies cell-specific senescence mechanisms
Hasanaj, E.; Beaulieu, D.; Wang, C.; Hu, Q.; Bueno, M.; Sembrat, J. C.; Pineda, R. H.; Melo-Narvaez, M. C.; Cardenes, N.; Yanwu, Z.; Yingze, Z.; Lafyatis, R.; Morris, A.; Mora, A.; Rojas, M.; Li, D.; Rahman, I.; Pryhuber, G. S.; Lehmann, M.; Alder, J.; Gurkar, A.; Finkel, T.; Ma, Q.; Poczos, B.; Bar-Joseph, Z.; Eickelberg, O.; Koenigshoff, M.
10.1101/2024.12.21.629928 — genomics — Posted on 2024-12-22
1093 STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs
Lee, H. K.; Chen, J.; Philips, R. L.; Lee, S.-G.; Feng, X.; Wu, Z.; Liu, C.; Schultz, A. B.; Dalzell, M.; Birnbaum, F.; Sexton, J. A.; Keating, A. E.; O'Shea, J. J.; Young, N. S.; Villarino, A. V.; Furth, P. A.; Hennighausen, L.
10.1101/2024.12.20.629685 — genetics — Posted on 2024-12-22
1097 Ilastik: a machine learning image analysis platform to interrogate stem cell fate decisions across multiple vertebrate species
Zuniga Munoz, A.; Soni, K.; Li, A.; Lakkundi, V.; Iyer, A.; Adler, A.; Kirkendall, K.; Petrigliano, F.; Benayoun, B. A.; Lozito, T.; Almada, A. E.
10.1101/2024.12.21.629913 — cell biology — Posted on 2024-12-22
1098 Sex-dimorphic gene regulation in murine macrophages across niches
McGill, C. J.; White, O. S.; Lu, R. J.; Sampathkumar, N. K.; Benayoun, B. A.
10.1101/2024.12.20.629843 — immunology — Posted on 2024-12-22
1099 SOD1 controls neutrophil oxidative burst and microbial killing
Foti, A.; Brinkmann, V.; Goosmann, C.; Meier, A.; Majer, T.
10.1101/2024.12.20.629705 — immunology — Posted on 2024-12-22
1100 Strain-level antigen variation facilitates immune evasion in Bacteroides thetaiotaomicron
Glowacki, R. W. P.; Till, J. M.; Brock, O. D.; Engelhart, M. J.; Ahern, P. P.
10.1101/2024.12.20.629425 — immunology — Posted on 2024-12-22
1102 Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action
Wilhelmsen, K.; Deshpande, A.; Tronnes, S.; Mahanta, M.; Banicki, M.; Cochran, M.; Cowdin, S.; Fortney, K.; Hartman, G.; Hughes, R.; Montgomery, R.; Portillo, C.; Rubin, P.; Wang, Y.; Yan, S.; Morgan, B. A.; Duisembekova, A.; Riou, R.; Marleaux, M.; Hochheiser, I. V.; Buthmann, H.; Ferber, D.; Wang, W.; Cranston, M.; McKee, C. M.; Mawhinney, T.; McKay, E.; Py, B. F.; Geyer, M.; Coll, R. C.
10.1101/2024.12.21.629867 — immunology — Posted on 2024-12-22
1104 The Septin Cytoskeleton is a Novel Regulator of Intestinal Epithelial Barrier Integrity and Mucosal Inflammation
Naydenov, N. G.; Hu, G.; Zafar, A.; Robak, D.; Makhmudova, K.; Lechuga, S.; Sagwan, N.; Bandyopadhay, S.; Musich, R.; Jeffrey, E.; Sun, L.; Marino-Melendez, A.; Rieder, F.; Sheynkman, G.; Ivanov, A. I.; Ebrahim, S.
10.1101/2024.12.20.629767 — physiology — Posted on 2024-12-22
1108 Intensive Chemotherapy Induces Cardiotoxicity via Reverse Electron Transport
Pinto, C.; Liu, Y.; Benaouadi, S.; Sainte-Marie, Y.; laaouimir, L.; Marsal, D.; van Gastel, N.; Savagner, F.; FARGE, T.
10.1101/2024.12.20.629711 — pathology — Posted on 2024-12-22
1109 KIF18A in HCC Metastasis: Dual Role in Anoikis Resistance and Chromosome Instability
Kan, C.; Bai, W.; Yang, X.; Hamdy, H.; Yang, X.; Liu, X.; Lv, Y.; Shen, J.; sun, j.
10.1101/2024.12.20.629627 — cancer biology — Posted on 2024-12-22
1110 DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
Tannus Ruckert, M.; McKinnon Walsh, R.; Bye, B. A.; Eades, A. E.; Yan, W.; Bednar, F.; Shi, J.; Lyssiotis, C. A.; VanSaun, M.; Silva Silveira, V.
10.1101/2024.12.20.629199 — cancer biology — Posted on 2024-12-22
1111 SMAD4 Mutation Drives Gut Microbiome Shifts Toward Tumor Progression in Colorectal Cancer
Gates, T. J.; Wangmo, D.; Boorsma-Bergerud, K. M.; Keel, B.; Staley, C. M.; Subramanian, S.
10.1101/2024.12.20.629749 — cancer biology — Posted on 2024-12-22
1112 Leukemia escapes immunity by imposing a Type-1 regulatory program on neoantigen-specific CD4+ T cells.
Venkatesh, H.; Heltemes-Harris, L.; Arroyo, M.; Knutson, T. P.; Qiu, Y.; Haaning, A. M.; Webber, B. R.; Bachanova, V.; Farrar, M. A.; Tracy, S.
10.1101/2024.12.21.629902 — cancer biology — Posted on 2024-12-22
1113 The farnesyl transferase inhibitor KO-2806 re-sensitizes relapsing tumors to RAS inhibition
Patel, H. V.; Smith, A. E.; Chan, S.; Gasendo, J. G.; Samantaray, T.; Kessler, L.; Mitra, A.; Zhu, X.; Liu, Y. A.; Burrows, F.; Malik, S.
10.1101/2024.12.20.629824 — cancer biology — Posted on 2024-12-22
1114 Anti-Cancer Immune Priming with Beta-Radioligand Therapy and Isoform-Selective Targeting of 4Ig-B7-H3
Glazer, S. E.; Sutton, M. N.; Yang, P.; Pisaneschi, F.; Sebastian, M. M.; Gammon, S. T.; Piwnica-Worms, D.
10.1101/2024.12.20.629740 — cancer biology — Posted on 2024-12-22
1115 Spatial transcriptomics exploration of the primary neuroblastoma microenvironment unveils novel paracrine interactions
Siaw, J. T.; Merseburger, P.; Borenas, M.; Jansson, C.; Karlsson, J.; Claeys, A.; Jennische, E.; Lind, D. E.; Gisselson Nord, D.; Palmer, R.; Van den Eynden, J.
10.1101/2024.12.21.629891 — cancer biology — Posted on 2024-12-22
1116 Direct observation of assembly and function of trigger responsive lipase biohybrids
Voutyritsa, E.; Soerensen, E. W.; Oikonomou, A.; Lazou, T.; Bushi, J.; Christensen, S. M.; Velonia, K.; Hatzakis, N. S.
10.1101/2024.12.20.629668 — biophysics — Posted on 2024-12-22
1118 Benchmarking AI Models for In Silico Gene Perturbation of Cells
Li, C.; Gao, H.; She, Y.; Bian, H.; Chen, Q.; Liu, K.; Wei, L.; Zhang, X.
10.1101/2024.12.20.629581 — bioinformatics — Posted on 2024-12-22
1119 A Co-essentiality Network of Cancer Driver Genes Better Prioritizes Anticancer Drugs
Lee, K.; Kim, D.; Kim, I.; Lee, J.; Ha, D.; Lim, S.; Kim, E.; Im, S.-H.; Shin, K.; Kim, S.
10.1101/2024.12.20.629566 — bioinformatics — Posted on 2024-12-22
1120 HAPP: High-Accuracy Pipeline for Processing deep metabarcoding data
Sundh, J.; Granqvist, E.; Iwaszkiewicz-Eggebrecht, E.; Manoharan, L.; van Dijk, L. J.- A.; Goodsell, R.; Godeiro, N.; Bellini, B.; Lukasik, P.; Miraldo, A.; Roslin, T.; Tack, A. J. M.; Andersson, A. A.; Ronquist, F.
10.1101/2024.12.20.629441 — bioinformatics — Posted on 2024-12-22
1128 PrimalScheme: open-source community resources for low-cost viral genome sequencing
Kent, C.; Smith, A. D.; Tyson, J.; Stepniak, D.; Kinganda-Lusamaki, E.; Lee, T.; Weaver, M.; Sparks, N.; Landsdowne, L.; Wilkinson, S. A.; Brier, T.; Colquhoun, R.; O'Toole, A. N.; Kingebeni, P. M.; Goodfellow, I. G.; Rambaut, A.; Loman, N. J.; Quick, J.
10.1101/2024.12.20.629611 — genomics — Posted on 2024-12-22
1129 Mitogenome Diversity and Phylogenetic Insights of Aedes albopictus in Greece
BALATSOS, G.; Karathanasi, V.; Evangelou, V.; Kapantaidaki, D.; Tegos, N.; Panagopoulou, A.; Bisia, M.; Karras, V.; Papachristos, D.; Papadopoulos, N. T.; Augustinos, A. A.; Patsoula, E.; Michaelakis, A.
10.1101/2024.12.20.629447 — genetics — Posted on 2024-12-22
1130 Engineering Adaptive Alleles for Escherichia coli Growth on Sucrose Using the EasyGuide CRISPR System
Barreto, J. A.; e Silva, M. V.; Marin, D. C.; Brienzo, M.; Jacobus, A. P.; Contiero, J.; Gross, J.
10.1101/2024.12.20.629655 — genetics — Posted on 2024-12-22
1131 Haplotype editing with CRISPR/Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL
Dua, P. H.; Simon, B. M.; Marley, C. B.; Feliciano, C. M.; Watry, H. L.; Steury, D.; Abraham, A.; Gilbertson, E. N.; Ramey, G. D.; Capra, J. A.; Conklin, B. R.; Judge, L. M.
10.1101/2024.12.20.629813 — genetics — Posted on 2024-12-22
1133 Genomic signals of local adaptation in Eleginops maclovinus from Northern Chilean Patagonia
Claure, C. E.; Larson, W.; McKinney, G. J.; Rocha, J. D.; Yanez, J. M.; Canales-Aguirre, C. B.
10.1101/2024.12.20.629640 — evolutionary biology — Posted on 2024-12-22
1134 Genomics of experimental adaptive radiation in the cryptic coloration of feather lice
Baldwin-Brown, J. G.; Villa, S.; Waight, E.; Johnson, K. P.; Bush, S. E.; Clayton, D. H.; Shapiro, M.
10.1101/2024.12.20.629508 — evolutionary biology — Posted on 2024-12-22
1135 RGB color indices as proxy for symbiont cell density and chlorophyll content during coral bleaching
Ferrara, E. F.; Bauer, L.; Puntin, G.; Bautz, F. R.; Celayir, S.; Do, M.-S.; Eck, F. L.; Heider, M. C.; Wissel, P. M.-C.; Arnold, A.; Wilke, T.; Reichert, J.; Ziegler, M.
10.1101/2024.12.20.629333 — ecology — Posted on 2024-12-22
1138 Conserved heavy/light contacts and germline preferences revealed by a large-scale analysis of natively paired human antibody sequences and structural data.
Dudzic, P.; Chomicz, D.; Bielska, W.; Jaszczyszyn, I.; Zielinski, M.; Janusz, B.; Wrobel, S.; Le Pannerer, M.-M.; Philips, A.; Ponraj, P.; Kumar, S.; Krawczyk, K.
10.1101/2024.12.20.629642 — immunology — Posted on 2024-12-22
1139 Acquisition of an immunosuppressive microenvironment after CAR-T therapy drives T-cell dysfunction and resistance
Ponzo, M.; Drufuca, L.; Buracchi, C.; Sindoni, M. M.; Nucera, S.; Bugarin, C.; Bason, R.; Rossetti, G.; Bonnal, R.; Meli, C.; Rambaldi, B.; Lussana, F.; Ferrari, S.; Moretti, A.; Risca, G.; Pellegrino, C.; Manz, M. G.; Galimberti, S.; Rambaldi, A.; Gaipa, G.; Biondi, A.; Pagani, M.; Magnani, C. F.
10.1101/2024.12.20.629119 — immunology — Posted on 2024-12-22
1141 Deleterious imprinting of perinatal exposure to nano-polystyrene on inflammatory bowel diseases
Airaud, M.; Roldan, A.; Le cleach, J.; Isoard, L.; Mas, E.; Carriere, M.; Menard, S.; Barreau, F.
10.1101/2024.12.20.629591 — pathology — Posted on 2024-12-22
1142 Discovery of a novel bandavirus using metagenomic sequencing in a retrospective analysis of an unresolved 2020 mortality event involving black vultures in the northeastern United States.
Mwakibete, L.; Hoarau, A. O. G.; Ahyong, V.; Waltari, E.; Bender, S. J.; Davison, S.; Niedringhaus, K. D.; Gibison, M. L.; Gagne, R. B.; Miller, E. A.; Murphy, L. A.; Kistler, A. L.; Tato, C. M.
10.1101/2024.12.21.629921 — genomics — Posted on 2024-12-22
1143 The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes
Lopez-Figueroa, C.; Cano, E.; Navarro, N.; Perez, M.; Lopez, R.; Skovgaard, K.; Vorsholt, H. T.; Heegaard, P. M. H.; Vergara-Alert, J.; Segales, J.
10.1101/2024.12.20.629601 — immunology — Posted on 2024-12-22
1144 PI3Kγ pathway contributes to neuroinflammation and neuronal death induced by Zika virus infection
Teixeira, D. C.; Campolina-Silva, G.; Marim, F. M.; Santos, F. R. d. S.; Queiroz-Junior, C. M.; Costa, P. A. C.; Tana, F. d. L.; Costa-Souza, L. P.; Pimenta, J. C.; Carvalho, J. G.; Beltrami, V. A.; Rocha, F. E. O.; Vieira, D. V.; Dornelas, E. G.; Ferreira, G. C.; Dias, F. F.; Guimaraes, P. P. G.; Ribas, V. T.; Teixeira, A. L.; Miranda, A. S.; Teixeira, M. M.; Souza, D. d. G.; Costa, V. V.
10.1101/2024.12.20.629712 — immunology — Posted on 2024-12-22
1145 Same-Slide Spatial Multi-Omics Integration Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment
Yeo, Y. Y.; Chang, Y.; Qiu, H.; Yiu, S. P. T.; Michel, H. A.; Wu, W.; Jin, X.; Kure, S.; Parmelee, L.; Luo, S.; Cramer, P.; Lee, J. L.; Wang, Y.; Yeung, J.; Ahmar, N. E.; Simsek, B.; Mohanna, R.; Orden, M. V.; Lu, W.; Livak, K. J.; Li, S.; Shahryari, J.; Kingsley, L.; Al-Humadi, R. N.; Nasr, S.; Nkosi, D.; Sadigh, S.; Rock, P.; Frauenfeld, L.; Kaufmann, L.; Zhu, B.; Basak, A.; Dhanikonda, N.; Chan, C. N.; Krull, J.; Cho, Y. W.; Chen, C.-Y.; Lee, J. Y. J.; Wang, H.; Zhao, B.; Loo, L.-H.; Kim, D. M.; Schurch, C. M.; Shalek, A. K.; Boussiotis, V.; Zhang, B.; Howitt, B.; Signoretti, S.; Hodi, F. S
10.1101/2024.12.20.629650 — systems biology — Posted on 2024-12-22
1150 Generation of antigen-specific paired heavy-light chain antibody sequences using large language models
Wasdin, P. T.; Johnson, N. V.; Janke, A. K.; Held, S.; Marinov, T. M.; Jordaan, G.; Vandenabeele, L.; Pantouli, F.; Gillespie, R. A.; Vukovich, M. J.; Holt, C. M.; Kim, J.; Hansman, G.; Logue, J.; Chu, H. Y.; Andrews, S. F.; Kanekiyo, M.; Sautto, G. A.; Ross, T. M.; Sheward, D. J.; McLellan, J. S.; Abu-Shmais, A. A.; Georgiev, I. S.
10.1101/2024.12.20.629482 — bioinformatics — Posted on 2024-12-22
1151 Bispecific antibody targeting of lipid nanoparticles
Amabile, A.; PHELAN, M.; YU, Z.; SILVA, P.; Marks, A.; MORLA-FOLCH, J.; Sohn, M.; Mollaoglu, G.; FALCOMATA, C.; Teunissen, A.; Brody, J.; Dong, Y.; Brown, B.
10.1101/2024.12.20.629467 — bioengineering — Posted on 2024-12-22
1153 Trapline foraging by nectar-collecting hornets
Lacombrade, M.; Abenis, K.; Doussot, C.; Goulefert, L.; Nanba, K.; Bonzom, J.-M.; Lihoreau, M.
10.1101/2024.12.22.629945 — animal behavior and cognition — Posted on 2024-12-22
1158 HapCNV: A Comprehensive Framework for CNV Detection in Low-input DNA Sequencing Data
Yu, X.; Qin, F.; Liu, S.; Brown, N. J.; Lu, Q.; Cai, G.; Guler, J. L.; Xiao, F.
10.1101/2024.12.19.629494 — bioinformatics — Posted on 2024-12-22
1159 Large complex structural rearrangements in human genomes harbor cryptic structures
Audano, P. A.; Paisie, C.; The Human Genome Structural Variation Consortium, ; Beck, C. R.
10.1101/2024.12.19.629504 — genomics — Posted on 2024-12-22
1160 Phylogenetic and functional diversity among Drosophila-associated metagenome-assembled genomes
Comeault, A. A.; Orta, A. H.; Fidler, D. B.; Nunn, T.; Ellison, A.; Anspach, T.; Matute, D. R.
10.1101/2024.12.19.629488 — genomics — Posted on 2024-12-22
1162 Mapping histological and functional maturation of human endocrine pancreas across early postnatal periods
Saunders, D. C.; Hart, N.; Pan, F. C.; Reihsmann, C. V.; Hopkirk, A. L.; Izmaylov, N.; Mei, S.; Sherrod, B. A.; Davis, C.; Duryea, J.; Haliyur, R.; Aramandla, R.; Durai, H.; Poffenberger, G.; Martin, A.; Posgai, A. L.; Kusmartseva, I.; Beery, M. L.; Yang, M.; Kang, H.; Greiner, D. L.; Shultz, L. D.; Cartailler, J.-P.; Aamodt, K. I.; Bottino, R.; Atkinson, M. A.; Wright, C. V. E.; Powers, A. C.; Brissova, M.
10.1101/2024.12.20.629754 — developmental biology — Posted on 2024-12-22
1163 A proteomic map of B cell activation and its shaping by mTORC1, MYC and iron
James, O.; Sinclair, L. V.; Lefter, N.; Salerno, F.; Brenes, A. J.; Howden, A. J.
10.1101/2024.12.19.629506 — immunology — Posted on 2024-12-22
1164 Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-retinal barrier integrity causing neurodegeneration.
Cueva Vargas, J. L.; Belforte, N.; Vidal-Paredes, I. A.; Dotigny, F.; Vande Velde, C.; Quintero, H.; Di Polo, A.
10.1101/2024.12.21.629919 — neuroscience — Posted on 2024-12-22
1165 Collapse of directed functional hierarchy under classical serotonergic psychedelics
Vohryzek, J.; Kringelbach, M. L.; Lopez-Sola, E.; Garcia Guzman, E.; Timmermann, C.; Roseman, L.; Tagliazucchi, E.; Ruffini, G.; Carhart-Harris, R.; Deco, G.; Sanz Perl, Y.
10.1101/2024.12.21.629922 — neuroscience — Posted on 2024-12-22
1167 Targeted-SMN insufficiency in Skeletal Muscle Stem Cells mediates non-cell autonomous loss of motor neurons at long term
Mecca, J.; Mignot, J.; Gervais, M.; Ozturk, T.; Astord, S.; Berthier, J.; Bauche, S.; Messeant, J.; Biferi, M.-G.; Rouard, H.; Barkats, M.; Relaix, F.; Didier, N.
10.1101/2024.12.19.629483 — pathology — Posted on 2024-12-22
1170 The mitotic chromosome periphery: a fluid coat that mediates chromosome mechanics
Mendonca, T.; Urban, R.; Lucken, K.; Coney, G.; Tassieri, M.; Kad, N. M.; Wright, A. J.; Booth, D. G.
10.1101/2024.12.21.628209 — biophysics — Posted on 2024-12-22
1171 The biophysical mechanism of mitochondrial pearling
Sturm, G.; Hake, K.; Lefebvre, A. E. Y. T.; Rux, C. J.; Ivanova, D.; Millett-Sikking, A.; Tharp, K. M.; Rao, B.; Closser, M.; Waite, A.; Precido-Lopez, M.; Dumont, S.; Lu, W.; Manley, S.; Landoni, J. C.; Marshall, W. F.
10.1101/2024.12.21.629509 — biophysics — Posted on 2024-12-22
1176 Solution biophysics identifies lipid nanoparticle non-sphericity, polydispersity, and dependence on internal ordering for efficacious mRNA delivery
Padilla, M.; Shepherd, S. J.; Hanna, A. R.; Kurnik, M.; Zhang, X.; Chen, M.; Byrnes, J.; Yamagata, H.; Ricciardi, A.; Joseph, R.; Mrksich, K.; Issadore, D.; Gupta, K.; Mitchell, M.
10.1101/2024.12.19.629496 — bioengineering — Posted on 2024-12-22
1177 The Rodent Electronic Nicotine Delivery System: Description and Validationof an Apparatus for Nose-Only E-Cigarette Aerosol Inhalation in Freely Moving Rats
Odum, A. L.; Willis-Moore, M. E.; Callister, K. T.; Haynes, J. M.; Frye, C. C. J.; Scribner, L. N.; Legaspi, D. N.; Da Silva, D. S.; Olsen, A. L.; Truscott, T. T.; Alden, P. T.; Bevins, R. A.; Leventhal, A. M.; Lee, S. T.; Gomer, B.; Benninghoff, A. D.
10.1101/2024.12.21.629932 — animal behavior and cognition — Posted on 2024-12-22
1178 Multiomic foundation model predicts epigenetic regulation by zero-shot
Yang, Z.; Fan, X.; Lan, M.; Li, X.; You, Y.; Tian, L.; Church, G.; Liu, X.; Gu, F.
10.1101/2024.12.19.629561 — genomics — Posted on 2024-12-22
1179 MrHAMER2: high-accuracy long-read RNA sequencing to decode isoform-specific variation in viral transcripts during latency
Gallardo, C. M.; Albert, J. L.; Qazi, A. A.; Ventura, R. L.; Deshmukh, S.; Beliakova-Bethell, N.; Torbett, B. E.
10.1101/2024.12.19.629526 — genomics — Posted on 2024-12-22
1181 Genomic insights into Plasmodium vivax and Plasmodium simium host shifts in Latin America
Lefebvre, M. J. M.; Degrugillier, F.; Arnathau, C.; Gonzalez, C. J. M.; Rondon, S.; Link, A.; Chaves, A.; Benavides, J. A.; Campos, A. A. S.; dos Santos, E.; Huff, R.; Silva, C. M. D.; Vanderheoven, E.; de Thoisy, B.; Fontaine, M. C.; Prugnolle, F.; Rougeron, V.
10.1101/2024.12.19.629455 — evolutionary biology — Posted on 2024-12-22
1184 Pearling Drives Mitochondrial DNA Nucleoid Distribution
Landoni, J. C.; Lycas, M. D.; Macuada, J.; Jaccard, R.; Obara, C. J.; Moore, A. S.; Ben Nejma, S.; Hoffman, D.; Lippincott-Schwartz, J.; Marshall, W.; Sturm, G.; Manley, S.
10.1101/2024.12.21.629917 — cell biology — Posted on 2024-12-22
1186 P2Y2 purinergic receptor and DNA sensor cGAS dictate ionizing radiation-mediated proinflammatory macrophage activation
Mostefa-Kara, A.; Deva Nathan, A.; Paoletti, A.; Chapel, A.; Gutierrez-Mateyron, E.; Cao-Pham, T. T.; Bou Ghosn, Y.; Allouch, A.; PERFETTINI, J.-L.
10.1101/2024.12.19.629560 — immunology — Posted on 2024-12-22
1187 Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment
Mantas, I.; Contestabile, A.; Skara, V.; Loiseau, C.; Santos, I.; Cramb, K.; Filograna, R.; Wade-Martins, R.; Magill, P.; Meletis, K.
10.1101/2024.12.22.629963 — neuroscience — Posted on 2024-12-22
1190 Engineering Saccharomyces cerevisiae for growth on xylose using an oxidative pathway
Tanaka, K.; Yukawa, T.; Bamba, T.; Wakiya, M.; Kumokita, R.; Yong-Su, J.; Kondo, A.; Hasunuma, T.
10.1101/2024.12.19.629315 — bioengineering — Posted on 2024-12-22
1191 Membrane lipid poly-unsaturation selectively affects ligand induced dopamine D2 receptor internalization
Sposini, S.; Baccouch, R.; Lescuyer, M.; De Smedt-Peyrusse, V.; Heuninck, J.; Durroux, T.; Trifilieff, P.; Perrais, D.; Alves, I.
10.1101/2023.12.14.571632 — cell biology — Posted on 2024-12-22
1193 Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease
Gaertner, Z.; Oram, C.; Schneeweis, A.; Schonfeld, E.; Bolduc, C.; Chen, C.; Dombeck, D. A.; Parisiadou, L.; Poulin, J. F.; Awatramani, R.
10.1101/2024.06.06.597807 — neuroscience — Posted on 2024-12-22
1194 MultiNMRFit: A software to fit 1D and pseudo-2D NMR spectra
Millard, P.; Le Gregam, L.; Dubiley, S.; Gosselin-Monplaisir, T.; Lippens, G.; Charlier, C.
10.1101/2024.12.19.629408 — bioinformatics — Posted on 2024-12-22
1197 The Plantae Visualization Platform: a comprehensive web-based tool for the integration, visualization, and analysis of omic data across plant and related species
Santiago, A.; Orduna, L.; Fernandez, J. D.; Vidal, A.; de Martin-Agirre, I.; Lison, P.; Vidal, E.; Navarro-Paya, D.; Matus, J. T.
10.1101/2024.12.19.629382 — bioinformatics — Posted on 2024-12-22
1199 Non-continuous neuromodulation in awake, unrestrained felines increases bladder capacity
Ortiz Lopez, M.; Ouyang, Z.; Kotkar, A.; Willen, M.; Liu, R.; Olszewski, J.; Stevens, M.; Kennedy, E.; Offutt, S. J.; Bittner, K. C.; Zirpel, L.; Bruns, T. M.
10.1101/2024.12.19.629379 — bioengineering — Posted on 2024-12-22
1205 GeneSetCluster 2.0: a comprehensive toolset for summarizing and integrating gene-sets analysis
Ortega-Legarreta, A.; Maillo, A.; Mouzo, D.; Lopez-Perez, A. R.; Kular, L.; Kakhki, M. P.; Tegner, J.; Jagodic, M.; Lagani, V.; Ewing, E.; Gomez-Cabrero, D.
10.1101/2024.12.18.629178 — bioinformatics — Posted on 2024-12-22
1206 CALIPERS: Cell cycle-aware live imaging for phenotyping experiments and regeneration studies
Di Sante, M.; Pezzotti, M.; Zimmermann, J.; Enrico, A.; Deschamps, J.; Balmas, E.; Becca, S.; Reali, A.; Bertero, A.; Jug, F.; Pasqualini, F.
10.1101/2024.12.19.629259 — bioengineering — Posted on 2024-12-22
1207 Contribution of front-line, standard of care drugs to bactericidal responses, resistance emergence, and cure in murine models of easy- or hard-to-treat tuberculosis disease
Peroutka-Bigus, N.; Brooks, E. J.; Ramey, M. E.; D'Erasmo, H.; Ernest, J. P.; Bauman, A. A.; Woolhiser, L. K.; Savic, R. M.; Lenaerts, A. J.; Aldridge, B.; Sarathy, J. P.; Robertson, G. T.
10.1101/2024.12.18.629278 — microbiology — Posted on 2024-12-22
1211 Heritable Immunization Establishes a New Model for Pathogen Control
Buchthal, J.; Chory, E. J.; Hill, Z.; Zhou, Y.; Bondage, D.; DeAmelio, S.; Freeman, J.; Jaenisch, R.; Markoulaki, S.; Marasco, W. A.; Telford, S.; Esvelt, K. M.
10.1101/2024.12.19.629026 — bioengineering — Posted on 2024-12-22
1213 The perceptions and roles of teachers and caregivers on play in promoting children's early learning and development in rural Kenya
Otwate, P. W.; Nampijja, M.; Onyango, S. O.; Langat, N.; Oloo, L.; Makhapila, E.; Mabongah, J.; Odhiambo, B.; Owuor, S.; Wekulo, P. K.
10.1101/2024.12.17.629004 — scientific communication and education — Posted on 2024-12-22
1216 Non-invasive diagnosis of early chronic colitis cancerization via amplified sensing of miRNA-21 in NIR-IIb window
Zhai, F.; Yun, B.; Ming, J.; Li, B.; Yu, T.; Liu, X.; Wang, X.; Chen, Z.-H.; Song, C.; Zhao, M.; Li, J.; Liang, A.; Zhang, F.
10.1101/2024.12.19.629405 — bioengineering — Posted on 2024-12-22
1217 Heat stress drives rapid viral and antiviral innate immunity activation in Hexacorallia
Sharoni, T.; Jaimes-Becerra, A.; Lewandowska, M.; Aharoni, R.; Voolstra, C. R.; Fine, M.; Moran, Y.
10.1101/2024.12.19.629480 — evolutionary biology — Posted on 2024-12-22
1222 Self-generated chemotaxis of mixed cell populations
Ucar, M. C.; Alsberga, Z.; Alanko, J.; Sixt, M.; Hannezo, E.
10.1101/2024.12.19.628881 — biophysics — Posted on 2024-12-22
1223 Thermal suppression of gametogenesis can explain historical collapses in larval recruitment
Okamoto, D. K.; Spindel, N.; Munstermann, M. J.; Karelitz, S.; Collicutt, B.; Gimenez, I.; Rolheiser, K.; Cronmiller, E.; Foss, M.; Mahara, N.; Swezey, D.; Ferraro, R.; Rogers-Bennett, L.; Schroeter, S.
10.1101/2023.09.28.559919 — ecology — Posted on 2024-12-22
1225 Human-Mouse Chimeric Brain Models to Study Human Glial-Neuronal and Macroglial-Microglial Interactions
Jin, M.; Ma, Z.; Zhang, H.; Papetti, A. V.; Dang, R.; Stillitano, A. C.; Zou, L.; Goldman, S. A.; Jiang, P.
10.1101/2024.07.03.601990 — neuroscience — Posted on 2024-12-22
1227 Targeted mutagenesis of specific genomic DNA sequences in animals for the in vivo generation of variant libraries
Falo-Sanjuan, J.; Diaz-Tirado, Y.; Turner, M. A.; Rourke, O.; Davis, J.; Medrano, C.; Haines, J.; McKenna, J.; Karshenas, A.; Eisen, M. B.; Garcia, H. G.
10.1101/2024.06.10.598328 — genetics — Posted on 2024-12-22
1229 Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer's disease biomarkers
Nedelkov, D.; Tsokolas, Z. E.; Matheus, S. R.; Sible, I.; Han, D.; Kerman, B. E.; Renteln, M.; Mack, W. J.; Tharick, P.; Yassine, H. N.
10.1101/2024.12.20.629619 — neuroscience — Posted on 2024-12-22
1231 SpaceExpress: a method for comparative spatial transcriptomics based on intrinsic coordinate systems of tissues
Kim, Y.; Ojha, A.; Schrader, A.; Lee, J.; Wu, Z.; Traniello, I. M.; Robinson, G. E.; Han, H. S.; Zhao, S. D.; Sinha, S.
10.1101/2024.12.19.628720 — bioinformatics — Posted on 2024-12-21
1232 Phage-displayed synthetic library and screening platform for nanobody discovery
Xia, B.; Kim, A.-R.; Liu, F.; Han, M.; Stoneburner, E.; Makdissi, S.; Di Cara, F.; Mohr, S.; Ring, A.; Perrimon, N.
10.1101/2024.12.20.629765 — biochemistry — Posted on 2024-12-21
1234 Double crossed? Structural and computational studies of an unusual crosslinked heme in Methylococcus capsulatus cytochrome P460
Pfalzgraf, H. E.; Rao, A. G.; Sen, K.; Adams, H. R.; Edwards, M.; Lu, Y.; Yong, C.; Jaho, S.; Tosha, T.; Sugimoto, H.; Horrell, S.; Beilsten-Edmands, J.; Owen, R. L.; Andrew, C. R.; Worrall, J. A. R.; Tews, I.; Mulholland, A. J.; Hough, M. A.; Keal, T. W.
10.1101/2024.12.21.628999 — biochemistry — Posted on 2024-12-21
1237 Bioengineered yeast tethered respiratory supercomplexes reveal mechanisms governing efficient substrate utilization
Eldeeb, M. H.; Cosner, Z.; Carlstrom, A.; Mays, J.-N.; Rodriguez, G. F.; Berndtsson, J.; Ott, M.; Fontanesi, F.
10.1101/2024.12.19.629262 — biochemistry — Posted on 2024-12-21
1238 Incorporating histone H2B variants into chromatin modifies chromatin accessibility to induce epithelial to mesenchymal transition in breast cancer
Dhahri, H.; Lau, K. H.; Saintilnord, W. N.; Lopes, E.; Damico, H. N.; Palma, F. R.; Melters, D. P.; Chandler, D. P.; Dalal, Y.; Licht, J. D.; Bonini, M. G.; Fondufe-Mittendorf, Y.
10.1101/2024.12.21.627414 — biochemistry — Posted on 2024-12-21
1241 Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma
Shishikura, K.; Li, J.; Chen, Y.; McKnight, N. R.; Bustin, K. A.; Barr, E. W.; Chilkamari, S. R.; Ayub, M.; Kim, S. W.; Lin, Z.; Hu, R.-M.; Hicks, K.; Wang, X.; O'Rourke, D. M.; Bollinger, J. M.; Binder, Z. A.; Parsons, W. H.; Martemyanov, K. A.; Liu, A.; Matthews, M. L.
10.1101/2024.12.19.629450 — biochemistry — Posted on 2024-12-21
1242 Stereochemical Insights into Sarpagan and Akuammiline Alkaloid Biosynthesis
Mann, S. G. A.; Paz-Galeano, M.; Shahsavarani, M.; Perley, J. O.; Guo, J.; Garza-Garcia, J. J. O.; Qu, Y.
10.1101/2024.12.19.629490 — biochemistry — Posted on 2024-12-21
1245 Chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage.
Joseph, J. T.; Wright, C. M.; Peixoto, E.; Khan, A.; Li, Y.; Neidigk, J. S. R.; Decker, O.; Imtiaz, A.; Jones, B. A.; Zhang, Y.; Shibata, E.; Gradilone, S.; Lewis, Z. A.; Contreras, R.; Sen, A.; Dutta, A.; Czaja, W.
10.1101/2024.12.19.629292 — molecular biology — Posted on 2024-12-21
1246 Brown Bears activates a Satiety Hormone Cholecystokinin (CCK) pathway in adipose tissue during hibernation
Henriksen, T. I.; Engelhard, C.; Frobert, A. M.; Schrölkamp, M.; Friebe, A.; Overgaard, M. T.; Poulsen, S. S.; Rehfeld, J.; Nielsen, J.; Fröbert, O.; Scheele, C.; Feizi, A.; Nielsen, S.
10.1101/2024.12.20.629672 — molecular biology — Posted on 2024-12-21
1250 Multi-Tissue Metabolomics Reveal mtDNA- and Diet-Specific Metabolite Profiles in a Mouse Model of Cardiometabolic Disease
Shastry, A.; Wilkinson, M. S.; Miller, D. M.; Kuriakose, M.; Veeneman, J. L.; Smith, M. R.; Hindmarch, C. C. T.; Dunham-Snary, K. J.
10.1101/2024.12.19.629398 — molecular biology — Posted on 2024-12-21
1252 Stress-driven emergence of heritable non-genetic drug resistance
Xie, J. L.; Yin, S.; Yang, T. S.; Chandrasekher, K.; Hanson, L.; Kim, S. H.; Esqueda, L.; Hogan, C. A.; Banaei, N.; Round, J.; Ost, K. S.; Berman, J.; Jarosz, D. F.
10.1101/2024.12.20.629823 — microbiology — Posted on 2024-12-21
1256 Spatio-temporal interaction of immune and renal cells determines glomerular crescent formation in autoimmune kidney disease
Sultana, Z.; Khatri, R.; Yousefi, B.; Shaikh, N.; Jauch-Speer, S. L.; Schaub, D. P.; Engesser, J.; Hellmig, M.; Hube, A. L.; Sivayoganathan, V.; Borchers, A.; Peters, A.; Kaffke, A.; Paust, H.-J.; Goldbeck-Strieder, T.; Wenzel, U. O.; Puelles, V.; Hoxha, E.; Wiech, T.; Huber, T. B.; Panzer, U.; Bonn, S.; Krebs, C. F.
10.1101/2024.12.18.629206 — immunology — Posted on 2024-12-21
1257 A Bi-Specific T Cell-Engaging Antibody Shows Potent Activity, Specificity, and Tumor Microenvironment Remodeling in Experimental Syngeneic and Genetically Engineered Models of GBM
Zannikou, M. Z.; Duffy, J. T.; Procissi, D.; Levine, R. N.; Hambardzumyan, D.; Lee-Chang, C.; Leoni, L.; Zhang, B.; Miska, J.; Balyasnikova, I. V.
10.1101/2024.12.18.628714 — immunology — Posted on 2024-12-21
1260 Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids
Nishimura, M.; Kodera, T.; Adachi, S.; Sato, A. Y.; Takeuchi, R. F.; Nonaka, H.; Hamachi, I.; Osakada, F.
10.1101/2024.12.21.629885 — neuroscience — Posted on 2024-12-21
1261 A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson's Disease
Fushiki, A.; Ng, D.; Lewis, Z. R.; Yadav, A.; Saraiva, T.; Hammand, L. A.; Wirblich, C.; Tasic, B.; Menon, V.; Silva, J. A. d.; Costa, R. M.
10.1101/2024.12.20.629776 — neuroscience — Posted on 2024-12-21
1264 Fossil Freshwater Fishes from the Pliocene of northern Colombia and the Palaeogeography of northern South America
Ballen, G. A.; Montes, C.; Carrillo-Briceno, J. D.; Bogan, S.; Reinales, S.; de Pinna, M.; Jaramillo, C.
10.1101/2024.12.18.629252 — paleontology — Posted on 2024-12-21
1265 The structural basis for de novo DNA methylation in chromatin
Xie, X.; Liu, M.; Zhou, X. E.; Dykstra, M. L.; Jones, P. A.; Worden, E. J.
10.1101/2024.12.19.629503 — biophysics — Posted on 2024-12-21
1266 The PH domain in the ArfGAP ASAP1 drives catalytic activation through an unprecedented allosteric mechanism
Soubias, O.; Foley, S. L.; Jian, X.; Jackson, R. A.; Zhang, Y.; Rosenberg, E. M.; Li, J.; Heinrich, F.; Johnson, M. E.; Sodt, A. J.; Randazzo, P. A.; Byrd, R. A.
10.1101/2024.12.20.629688 — biochemistry — Posted on 2024-12-21
1269 Field monitoring and hydraulic modelling quantify untreated wastewater as dominant source of AMR in a small river running through a big city
Sonkar, V.; Kashyap, A.; Pallares-Vega, R.; Sasidharan, S. S.; Modi, A.; Uluseker, C.; Chandrakalabai Jambu, S.; Mohapatra, P. K.; Larsen, J.; Graham, D. W.; Thatikonda, S.; Kreft, J.-U.; AMRflows consortium,
10.1101/2024.12.21.629897 — microbiology — Posted on 2024-12-21
1270 Who said that? Deciphering Complex Coral Reef Soundscapes with Spatial Audio and 360 Degree Video
Dantzker, M. S.; Duggan, M. T.; Berlik, E.; Delikaris-Manias, S.; Bountourakis, V.; Pulkki, V.; Rice, A. N.
10.1101/2024.12.16.628659 — ecology — Posted on 2024-12-21
1271 A targetable developmental program co-regulates angiogenesis and immune evasion
Berico, P.; Flores Yanke, A. F.; Vand Rajabpour, F.; Do, C.; Simonin Wilmer, I.; Sakellaropoulos, T.; Delclaux Obieta, I.; Stagnitta, R.; Vazquez Cruz, E.; Osman, I.; Skok, J.; Robles-Espinoza, C. D.; Lund, A. W.; Schober, M.; Hernando, E.
10.1101/2024.12.21.628442 — cancer biology — Posted on 2024-12-21
1275 A Framework for Autonomous AI-Driven Drug Discovery
Selinger, D. W.; Wall, T. R.; Stylianou, E.; Khalil, E. M.; Gaetz, J.; Levy, O.
10.1101/2024.12.17.629024 — bioinformatics — Posted on 2024-12-21
1278 Concordance between male- and female-specific GWAS results helps define underlying genetic architecture of complex traits
Miller, A. K.; Pan, C.; Bartlett, J.; Lusis, A. J.; Crawford, D. C.; Williams, S. M.; Buchner, D. A.
10.1101/2022.09.28.509932 — genetics — Posted on 2024-12-21
1281 Cryo-EM structures of engineered Shiga toxin-based immunogens capable of eliciting neutralizing antibodies with therapeutic potential against Hemolytic Uremic Syndrome
Cristofalo, A. E.; Sharma, A.; Cerutti, M. L.; Sharma, K.; Melero, R.; Pardo, R.; Goldbaum, F. A.; Borgnia, M.; Zylberman, V.; Otero, L. H.
10.1101/2024.12.21.626268 — immunology — Posted on 2024-12-21
1282 Coordinated alternative splicing decisions via stepwise exon definition
Kristofori, P.; Braun, S.; Busch, A.; Zarnack, K.; Koenig, J.; Legewie, S.; Li, C.
10.1101/2024.12.18.629257 — systems biology — Posted on 2024-12-21
1283 EpiAgent: Foundation model for single-cell epigenomic data
Chen, X.; Li, K.; Cui, X.; Wang, Z.; Jiang, Q.; Lin, J.; Li, Z.; Gao, Z.; Jiang, R.
10.1101/2024.12.19.629312 — bioinformatics — Posted on 2024-12-21
1288 LAG3 marks activated but hyporesponsive NK cells.
Vasilyeva, V.; Makinson, O.; Chan, C.; Park, M.; O'Dwyer, C.; Ali, A.; Abrar, U. H. K.; Tanese de Souza, C.; Hasim, M. S.; Asif, S.; Kurdieh, R.; Abou-Hamad, J.; Yakubovich, E.; Hodgins, J.; Al Haddad, P.; Pietropaolo, G.; Mazzei, J.; Seo, H.; Huang, Q.; Nersesian, S.; Chay, D.; Jacquelot, N.; Cook, D.; Lee, S.-H.; Sciume, G.; Waggoner, S. N.; Ardolino, M.; Marotel, M.
10.1101/2024.12.18.629184 — immunology — Posted on 2024-12-21
1289 Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human
Lancaster, M. A.; Lloyd-Davies Sanchez, D. J.; Lindhout, F.; Anderson, A. J.; Pellegrini, L.
10.1101/2024.12.21.629881 — neuroscience — Posted on 2024-12-21
1291 Spanning spatial scales with functional imaging in the human brain; initial experiences at 10.5 Tesla
Vizioli, L.; Moeller, S.; Dowdle, L.; Grant, A.; Sadeghi-Tarakameh, A.; Eryaman, Y.; Lagore, R.; Auerbach, E.; Adriany, G.; Knudsen, L.; De Martino, F.; Faes, L.; Yacoub, E.; Ugurbil, K.
10.1101/2024.12.20.629800 — neuroscience — Posted on 2024-12-21
1292 Accelerating Wound Healing Through Deep Reinforcement Learning: A Data-Driven Approach to Optimal Treatment
Lu, F.; Zlobina, K.; Baniya, P.; Li, H.; Rondoni, N. A.; Asefifeyzabadi, N.; Hee, W. S.; Tebyani, M.; Schorger, K.; Franco, C.; Bagood, M.; Teodorescu, M.; Rolandi, M.; Isseroff, R.; Gomez, M.
10.1101/2024.12.18.629218 — systems biology — Posted on 2024-12-21
1293 The ketone body β-Hydroxybutyrate mediated epigenetic chromatin β-hydroxybutyrylation protects kidneys
Mandal, J.; Aryal, S.; Manandhar, I.; Chakraborty, S.; Mei, X.; Yeoh, B. S.; Mell, B.; Kleinhenz, A.; Tummala, R.; Yang, T.; Saha, P.; Gunning, W. T.; Vijay-Kumar, M.; Basrur, V.; de la Serna, I.; Joe, B.
10.1101/2024.12.18.628574 — physiology — Posted on 2024-12-21
1294 PRLX-93936 and BMS-214662 are cytotoxic molecular glues that leverage TRIM21 to degrade nucleoporins
Scemama de Gialluly, M. A.; Allen, A. R.; Hayes, E. H.; Zhuang, P.; Goldfarb, R. B.; Farrar, A. N.; Fedorov, Y.; Adams, D. J.
10.1101/2024.12.18.629219 — pharmacology and toxicology — Posted on 2024-12-21
1295 Integrating Ambient Mass Spectrometry Imaging and Spatial Transcriptomics on the Same Cancer Tissues to Identify Gene-Metabolite Correlations
Godfrey, T. M.; Shanneik, Y.; Zhang, W.; Tran, T.; Verbeeck, N.; Patterson, N. H.; Jackobs, F. E.; Nagi, C.; Ramineni, M.; Schiavinato Eberlin, L.
10.1101/2024.12.20.626670 — cancer biology — Posted on 2024-12-21
1296 Expanding the diversity of nitroxide-based paramagnetic probes conjugated to non-canonical amino acids for SDSL-EPR applications
Bizet, M.; Balazsi, A.; Biaso, F.; Byrne, D.; Etienne, E.; Guigliarelli, B.; Urban, P.; Dorlet, P.; Truan, G.; Gerbaud, G.; Kalai, T.; Martinho, M.
10.1101/2024.12.18.629154 — biophysics — Posted on 2024-12-21
1298 Benchmarking scRNA-seq copy number variation callers
Schmid, K. T.; Symeonidi, A.; Hlushchenko, D.; Richter, M. L.; Colome-Tatche, M.
10.1101/2024.12.18.629083 — bioinformatics — Posted on 2024-12-21
1300 Recovery of highly contiguous genomes from complex terrestrial habitats reveals over 15,000 novel prokaryotic species and expands characterization of soil and sediment microbial communities
Sereika, M.; Mussig, A. J.; Jiang, C.; Knudsen, K. S.; Jensen, T.; Petriglieri, F.; Yang, Y.; Jorgensen, V. R.; Delogu, F.; Sorensen, E. A.; Nielsen, P. H.; Singleton, C. M.; Hugenholtz, P.; Albertsen, M.
10.1101/2024.12.19.629313 — bioinformatics — Posted on 2024-12-21
1301 Bacteria-powered living materials enable coral larval settlement
Levy, N.; Kundu, S.; Freckelton, M. L.; Dinasquet, J.; Flores, I.; Galindo-Martinez, C. T.; Tresguerres, M.; De La Garza, V.; Sun, Y.; Karimi, Z.; Drury, C.; Jury, C. P.; Hancock, J.; Chen, S.; Hadfield, M. G.; R3D Consortium, ; Wangpraseurt, D.
10.1101/2024.12.18.629188 — bioengineering — Posted on 2024-12-21
1303 Microphysiological uremia model reveals biophysical potentiators of vascular dysfunction
Rathod, M.; Huang, S.; Aw, W. Y.; Doherty, E.; Meehan, S.; Roy-Chaudhury, P.; Polacheck, W. J.
10.1101/2024.12.18.629161 — bioengineering — Posted on 2024-12-21
1306 Regulation of epigenetics and chromosome structure by human ORC2
Su, Z.; Tian, M.; Shibata, E.; Shibata, Y.; Yang, T.; Wang, Z.; Jin, F.; Zang, C.; Dutta, A.
10.1101/2024.12.18.629220 — genomics — Posted on 2024-12-21
1309 Replication stress increases de novo CNVs across the malaria parasite genome
Brown, N. J.; Luniewski, A.; YU, X.; Warthan, M. D.; Liu, S.; Zulawinska, J.; Ahmad, S.; Congdon, M.; Santos, W.; Xiao, F.; Guler, J. L.
10.1101/2024.12.19.629492 — genomics — Posted on 2024-12-21
1311 Sex-dependent influence of major histocompatibility complex diversity on fitness in a social mammal
Schubert, N.; Nichols, H. J.; Mwanguhya, F.; Businge, R.; Kyambulima, S.; Mwesige, K.; Hoffman, J. I.; Cant, M. A.; Winternitz, J. C.
10.1101/2024.12.18.629201 — evolutionary biology — Posted on 2024-12-21
1316 Human class B1 GPCR modulation by plasma membrane lipids
Chao, K. W.; Wong, L.; Oqua, A.; Kalayan, J.; Manchanda, Y.; Gebbie-Rayet, J.; Hedger, G.; Tomas, A.; Rouse, S. L.
10.1101/2024.12.19.629375 — molecular biology — Posted on 2024-12-21
1317 Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta
Ganta, K. K.; McManus, M.; Blanc, R.; Wang, Q.; Jung, W.; Brody, R.; Carrington, M.; Paris, R.; Chandramouli, S.; McNamara, R.; Luzuriaga, K.
10.1101/2024.12.18.629009 — immunology — Posted on 2024-12-21
1318 CD4+ T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions
Schrangl, L.; Kellner, F.; Platzer, R.; Muhlgrabner, V.; Hubinger, P.; Wieland, J.; Obst, R.; Toca-Herrera, J. L.; Huppa, J. B.; Schutz, G. J.; Gohring, J.
10.1101/2024.12.18.629139 — immunology — Posted on 2024-12-21
1327 Asymmetries in foveal vision
Jenks, S. K.; Carrasco, M.; Poletti, M.
10.1101/2024.12.20.629715 — neuroscience — Posted on 2024-12-21
1333 Design and Validation of a Wearable Imaging System for Automated Wound Monitoring in Porcine Model
HEE, W. S.; Tebyani, M.; Baniya, P.; Franco, C.; Keller, G.; Lu, F.; Li, H.; Asefifeyzabadi, N.; Yang, H.-y.; Villa-Martinez, G.; Schorger, K.; Devarajan, K.; Barbee, A.; Hernandez, C.; Nguyen, T.; Gomez, M.; Isseroff, R. R.; Rolandi, M.; Teodorescu, M.
10.1101/2024.12.18.629174 — bioengineering — Posted on 2024-12-21
1335 Remote-Controlled Wireless Bioelectronics for Fluoxetine Therapy to Promote Wound Healing in a Porcine Model
Li, H.; Asefifeyzabadi, N.; Schorger, K.; Baniya, P.; Tebyani, M.; Barbee, A.; Yang, H.; Hee, W. S.; gallegos, a.; Zhu, K.; Recendez, C.; Luka, G.; Kim, S.; Devarajan, K.; Nguyen, T.; Figuerres, S.; Franco, C.; Aslankoohi, E.; Zhao, M.; Isseroff, R. R.; Teodorescu, M.; Rolandi, M.
10.1101/2024.12.18.629272 — bioengineering — Posted on 2024-12-21
1337 Applying computational protein design to engineer affibodies for affinity-controlled delivery of vascular endothelial growth factor and platelet-derived growth factor
Svendsen, J. E.; Ford, M. R.; Asnes, C. L.; Oh, S. C.; Dorogin, J.; Fear, K. M.; O'Hara-Smith, J. R.; Harms, M. J.; Hosseinzadeh, P.; Hettiaratchi, M. H.
10.1101/2024.12.18.629300 — bioengineering — Posted on 2024-12-21
1341 Variation of tooth traits in ecologically specialized and sympatric morphs
Jonsdottir, G. O.; Ingimarsson, F.; Snorrason, S. S.; Steele, S. E.; Palsson, A.
10.1101/2024.12.18.629189 — evolutionary biology — Posted on 2024-12-21
1344 Frataxin deficiency in the astrocytes drives neurocognitive impairment in sickle cell disease mice
Novelli, E. M.; Lenhart, S.; Foley, L. M.; Sekar, N.; Mondal, P.; Wang, H.; Hitchens, T. K.; Ghosh, S.; Chan, S. Y.; Hu, X.; Hazra, R.
10.1101/2024.12.20.629760 — neuroscience — Posted on 2024-12-21
1345 Neuronal representation of the decisional reference point in monkeys
Nguyen, D.; Rich, E. L.; Wallis, J. D.; Louie, K.; Glimcher, P. W.
10.1101/2024.12.20.629801 — neuroscience — Posted on 2024-12-21
1347 Development and early life stress sensitivity of the rat cortical microstructural similarity network
Smith, R. L.; Sawiak, S. J.; Dorfschmidt, L.; Dutcher, E. G.; Jones, J. A.; Hahn, J. D.; Sporns, O.; Swanson, L. W.; Taylor, P. A.; Glen, D. R.; Dalley, J. W.; McMahon, F. J.; Raznahan, A.; Vertes, P. E.; Bullmore, E. T.
10.1101/2024.12.20.629759 — neuroscience — Posted on 2024-12-21
1348 Decreased BOLD signal variability in middle-aged and older adults on the Autism Spectrum
Pedrahita, S.; Linke, A. C.; Cordova, M.; Wilkinson, M.; Hau, J.; Toro, G.; Alemu, K.; Kohli, J.; Muller, R.-A.; Carper, R.
10.1101/2024.12.21.629918 — neuroscience — Posted on 2024-12-21
1349 Human shape perception spontaneously discovers the biological origin of novel, but natural, stimuli
Dehn, K. I.; Maiello, G.; Hartmann, F. T.; Morgenstern, Y.; Hawkins, S. J.; Offner, T.; Walter, J.; Hassenklöver, T.; Manzini, I.; Fleming, R. W.
10.1101/2024.12.21.629735 — neuroscience — Posted on 2024-12-21
1350 A molecularly defined brain circuit module for regulating the panic-like defensive state
Zhao, M.; Zhang, L.; Chen, Z.; Zhang, S.; Cheng, X.; Huang, M.; Li, X.; Gu, H.; Guan, X.; Geng, D.; Li, Y.; Tu, Y.; Xie, Z.; Zhang, F.; Ma, H.; Li, D.; Wu, Q.; Cao, P.
10.1101/2024.12.20.629854 — neuroscience — Posted on 2024-12-21
1351 Effortful control and cortical brain structure in 5-year-old children: findings from the FinnBrain birth cohort study
Frantti, M.; Tuulari, J. J.; Nolvi, S.; Nordenswan, E.; Copeland, A.; Kumpulainen, V.; Silver, E.; Merisaari, H.; Saukko, E.; Kataja, E.-L.; Korja, R.; Karlsson, L.; Karlsson, H.; Pulli, E. P.
10.1101/2024.12.21.629905 — neuroscience — Posted on 2024-12-21
1355 Transport kinetics across interfaces between coexisting liquid phases
Hubatsch, L.; Bo, S.; Harmon, T. S.; Hyman, A. A.; Weber, C. A.; Julicher, F.
10.1101/2024.12.20.629798 — biophysics — Posted on 2024-12-21
1356 LC3 forms functional nanocluster on autophagosome
Fatihi, S.; Khushalani, D. M.; Kar, J.; Mohan, N.; Thukral, L.
10.1101/2024.12.21.629869 — biophysics — Posted on 2024-12-21
1360 The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model
Morais, L. H.; Stiles, L.; Freeman, M.; Oguienko, A. D.; Hoang, J. D.; Jones, J.; Quan, B.; Devine, J.; Bois, J. S.; Chou, T.-F.; Trinh, J.; Picard, M.; Gradinaru, V.; Mazmanian, S. K.
10.1101/2024.12.18.629251 — physiology — Posted on 2024-12-21
1361 Cells Prioritize the Regulation of Cell Mass Density
Fu, J.; Ni, Q.; Wu, Y.; Gupta, A.; Ge, Z.; Yang, H.; Afrida, Y.; Barman, I.; Sun, S.
10.1101/2024.12.10.627803 — biophysics — Posted on 2024-12-21
1362 A personalized multi-platform assessment of somatic mosaicism in the human frontal cortex
Zhou, W.; Mumm, C.; Gan, Y.; Switzenberg, J. A.; Wang, J.; De Oliveira, P.; Kathuria, K.; Losh, S. J.; McDonald, T. L.; Bessell, B.; Van Deynze, K.; McConnell, M. J.; Boyle, A. P.; Mills, R. E.
10.1101/2024.12.18.629274 — genomics — Posted on 2024-12-21
1363 Phased genome assemblies and pangenome graphs of human populations of Japan and Saudi Arabia
Kulmanov, M.; Ashouri, S.; Liu, Y.; Abdelhakim, M.; Alsolme, E.; Nagasaki, M.; Ohkawa, Y.; Suzuki, Y.; Tawfiq, R.; Tokunaga, K.; Katayama, T.; Abedalthagafi, M. S.; Hoehndorf, R.; Kawai, Y.
10.1101/2024.12.18.628902 — genomics — Posted on 2024-12-21
1368 A simple method to efficiently generate structural variation in plants
Bechen, L. L.; Ahsan, N.; Bahrainwala, A.; Gehring, M.; Rajavasireddy, S.
10.1101/2024.12.20.629831 — plant biology — Posted on 2024-12-21
1369 Killer Toxin K28 resistance in yeast relies on COG complex mediated trafficking of the defence factor Ktd1
Laidlaw, K.; Nadir, H.; Milburn, A.; Cruz, M.; Stanislovas, J.; Droop, A.; MacDonald, S.; Andreev, I.; Leech, A.; Ungar, D.; Sadhu, M. J.; MacDonald, C.
10.1101/2024.12.20.629825 — cell biology — Posted on 2024-12-21
1377 Fraxinus excelsior updated long-read genome reveals the importance of MADS-box genes in tolerance mechanisms against ash dieback
Franco Ortega, S.; Bedford, J. A.; James, S. R.; Newling, K.; Ashton, P. D.; Boshier, D. H.; Clark, J.; Hartley, S. E.; Harper, A. L.
10.1101/2024.12.20.629733 — plant biology — Posted on 2024-12-21
1378 The TUTase URT1 regulates the transcriptome of seeds and their primary dormancy
Peter, J.; Roignant, J.; Sacharowski, S.; Ubrig, E.; Lefevre, B.; Swiezewski, S.; Gagliardi, D.; Zuber, H.
10.1101/2024.12.19.629392 — plant biology — Posted on 2024-12-21
1379 Warm temperature modifies cell fates to reduce stomata production in Arabidopsis
Saiz-Perez, J.; Baekelandt, A.; Illescas-Miranda, J.; Sterck, L.; Vuylsteke, M.; Kim, E. J.; Guo, B.; Desvoyes, B.; Gutierrez, C.; Russinova, E.; Fenoll, C.; Mena, M.
10.1101/2024.12.19.629334 — plant biology — Posted on 2024-12-21
1380 Coenzyme M: An Archaeal Antioxidant as an Agricultural Biostimulant
Brown, J. H.; Vijayan, J.; Rodrigues de Queiroz, A.; Ramos, N. F.; Bickford, N.; wuellner, M.; Buan, N. R.; Stone, J. M.; Glowacka, K.; Roston, R. L.
10.1101/2024.12.20.629737 — plant biology — Posted on 2024-12-21
1381 Spatial Transcriptomics Reveals Expression Gradients in Developing Wheat Inflorescences at Cellular Resolution
Long, K. A.; Lister, A.; Jones, M. R. W.; Adamski, N. M.; Ellis, R. E.; Chedid, C.; Carpenter, S. J.; Liu, X.; Backhaus, A. E.; Goldson, A.; Knitlhoffer, V.; Pei, Y.; Vickers, M.; Steuernagel, B.; Kaithakottil, G. G.; Xiao, J.; Haerty, W.; Macaulay, I. C.; Uauy, C.
10.1101/2024.12.19.629411 — plant biology — Posted on 2024-12-21
1384 A long-distance inhibitory system regulates haustoria numbers in parasitic plants
Kokla, A.; Leso, M.; Simura, J.; Wardig, C.; Hayashi, M.; Nishii, N.; Tsuchiya, Y.; Ljung, K.; Melnyk, C. W.
10.1101/2024.12.19.629485 — plant biology — Posted on 2024-12-21
1385 A haplotype-based evolutionary history of barley domestication
Guo, Y.; Jayakodi, M.; Himmelbach, A.; Ben-Yosef, E.; Davidovich, U.; David, M.; Hartmann-Shenkman, A.; Kislev, M.; Fahima, T.; Schuenemann, V.; Reiter, E.; Krause, J.; Steffenson, B. J.; Stein, N.; Weiss, E.; Mascher, M.
10.1101/2024.12.18.628695 — plant biology — Posted on 2024-12-21
1386 Multiomics plasticity in seed traits of pan-genome wheat cultivars
Bose, U.; Winkler, J. B.; Sorg, E.; Mitu, S. A.; Huber, G.; Koller, R.; Beale, D.; Dawson, A.; Escobar-Correas, S.; Biswas, B.; Rahman, M.; Stockwell, S.; Byrne, K.; Broadbent, J.; Neerukonda, M.; Buegger, F.; Sigalas, A.; Mayer, K. F. X.; Schuppan, D.; Pozniak, C.; Colgrave, M.; Spannagl, M.; Juhasz, A.; Schnitzler, J.-P.
10.1101/2024.12.20.629680 — plant biology — Posted on 2024-12-21
1387 Attracting indigenous pollinators to urban greenspaces
Mata, L.; Palma, E.; Dawe, S.; Keenan, M.; Wolfe, P.; Hahs, A. K.
10.1101/2024.12.17.629021 — ecology — Posted on 2024-12-21
1388 The cell biology and genome of Stentor pyriformis, a giant cell that embeds symbiotic algae in a microtubule meshwork
Boudreau, v.; Albright, A. R.; Gerbich, T.; Fadero, T.; Yan, V.; Larson, B.; Lucas-DeMott, A.; Yung, J.; Moulin, S.; Descovich, C. P.; Slabodnick, M. M.; Burlacot, A.; Wang, J.; Niyogi, K. K.; Marshall, W. F.
10.1101/2024.12.19.629502 — cell biology — Posted on 2024-12-21
1389 Bovine endometrial organoids: A new tool to study conceptus-maternal interactions in mammals
Edge, J. C.; Amelkina, O.; Tinning, H.; Giovanardi, G.; Mancinelli, E.; Gardner, S.; Vasconcelos, E. J.; Pensabene, V.; Forbes, K.; OConnell, M. J.; Ruane, P.; Forde, N.
10.1101/2024.12.13.628419 — cell biology — Posted on 2024-12-21
1391 Joint models reveal human subcortical underpinnings of choice and learning behaviour
Miletic, S.; Stevenson, N.; Bazin, P.-L.; Alkemade, A.; Isherwood, S. J. S.; Trutti, A. C.; Tse, D. H. Y.; Haberg, A. K.; Forstmann, B.
10.1101/2024.12.20.629647 — neuroscience — Posted on 2024-12-21
1392 Syn-tasiR-VIGS: Virus-Based Targeted RNAi in Plants By Synthetic Trans Acting Small Interfering RNAs Derived from Minimal Precursors
Cisneros, A. E.; Alarcia, A.; Llorens-Gamez, J. J.; Puertes, A.; Juarez-Molina, M.; Primc, A.; Carbonell, A.
10.1101/2024.12.18.629176 — plant biology — Posted on 2024-12-21
1393 Sex-related differences in vascular remodeling of sodium overloaded normotensive mice
Viegas, K. A. d. S.; Silva, J. C. d. S.; Lima, R. S. d.; Lima, C. T.; Peron, N. N.; Silva, M. B. d.; Irigoyen, M. C.; Lacchini, S.
10.1101/2024.07.09.602349 — physiology — Posted on 2024-12-21
1394 Identification of PTGR2 inhibitors as a new therapy for diabetes and obesity
Chang, Y.-C.; Hsieh, M.-L.; Lee, H.-L.; Hee, S.-W.; Chang, C.-F.; Yen, H.-Y.; Chen, Y.-A.; Chen, Y.-R.; Chou, Y.-W.; Li, F.-A.; Ke, Y.-Y.; Chen, S.-Y.; Hung, M.-S.; Hung, A. F.-H.; Huang, J.-Y.; Chiu, C.-H.; Lin, S.-Y.; Shih, S.-F.; Hsu, C.-N.; Hwang, J.-J.; Yeh, T.-K.; Cheng, T.-J. R.; Liao, K. C.-W.; Liao, D.; Lin, S.-W.; Chen, T.-Y.; Hu, C.-M.; Vogel, U. B.; Saar, D.; Kragelund, B. B.; Tsou, L. K.; Tseng, Y.-H.; Chuang, L.-M.
10.1101/2024.12.17.629058 — physiology — Posted on 2024-12-21
1395 Proteome-scale quantification of the interactions driving condensate formation of intrinsically disordered proteins
Norrild, R. K.; von Buelow, S.; Halldorsson, E.; Lindorff-Larsen, K.; Rogers, J. M.; Buell, A. K.
10.1101/2024.12.21.629870 — biophysics — Posted on 2024-12-21
1396 Single-particle tracking reveals heterogeneous PIEZO1 diffusion
Ly, A. T.; Freites, J. A.; Bertaccini, G. A.; Evans, E. L.; Dickinson, G. D.; Tobias, D. J.; Pathak, M. M.
10.1101/2022.09.30.510193 — biophysics — Posted on 2024-12-21
1397 PhyloFunc: Phylogeny-informed Functional Distance as a New Ecological Metric for Metaproteomic Data Analysis
Wang, L.; Simopoulos, C. M. A.; Serrana, J. M.; Ning, Z.; Li, Y.; Sun, B.; Yuan, J.; Figeys, D.; Li, L.
10.1101/2024.05.28.596184 — bioinformatics — Posted on 2024-12-21
1399 Eclipse: A Python package for alignment of two or more nontargeted LC-MS metabolomics datasets
Hitchcock, D. S.; Krejci, J. N.; Sturgeon, C. E.; Dennis, C. A.; Jeanfavre, S. T.; Avila-Pacheco, J. R.; Clish, C. B.
10.1101/2023.06.09.544417 — bioinformatics — Posted on 2024-12-21
1401 Computational design of bifaceted protein nanomaterials
Rankovic, S.; Carr, K. D.; Decarreau, J.; Skotheim, R.; Kibler, R. D.; Ols, S.; Lee, S.; Chun, J.-H.; Tooley, M. R.; Dauparas, J.; Eisenach, H. E.; Gloegl, M.; Weidle, C.; Borst, A. J.; Baker, D.; King, N. P.
10.1101/2024.10.18.619149 — bioengineering — Posted on 2024-12-21
1402 Ketogenesis protects against MASLD-MASH progression through mechanisms that extend beyond overall fat oxidation rate
Queathem, E. D.; Stagg, D.; Nelson, A.; Chaves, A. B.; Crown, S. B.; Fulghum, K.; d`Avignon, D. A.; Ryder, J. R.; Bolan, P. J.; Hayir, A.; Gillingham, J. R.; Jannatpour, S.; Rome, F. I.; Williams, A. S.; Muoio, D. M.; Ikramuddin, S.; Hughey, C. C.; Puchalska, P.; Crawford, P. A.
10.1101/2024.10.17.618895 — biochemistry — Posted on 2024-12-21
1405 Developmental delay ensures global tissue size robustness upon local induction of apoptosis
Staneva, R.; Sobczyk-Moran, G.; Levillayer, F.; Villars, A.; Davidovic, A.; Levayer, R.
10.1101/2024.12.21.629882 — developmental biology — Posted on 2024-12-21
1406 The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action
Buttress, J. A.; Schaefer, A.-B.; Koh, A.; Wheatley, J.; Mickiewicz, K.; Wenzel, M.; Strahl, H.
10.1101/2024.12.20.629673 — microbiology — Posted on 2024-12-21
1408 Adaptive planning depth in human problem solving
Eluchans, M.; Lancia, G. L.; Maselli, A.; D'Alessandro, M.; Gordon, J.; Pezzulo, G.
10.1101/2023.05.02.539099 — neuroscience — Posted on 2024-12-21
1409 Bifurcation in space: Emergence of function modularity in the neocortex
Wang, X.-J.; Jiang, J.; Zeraati, R.; Pereira-Obilinovic, U.; Battista, A.; Vezoli, J.; Kennedy, H.
10.1101/2023.06.04.543639 — neuroscience — Posted on 2024-12-21
1410 A simple framework for agent-based modeling with extracellular matrix
Metzcar, J.; Duggan, B. S.; Fischer, B.; Murphy, M.; Heiland, R.; Macklin, P.
10.1101/2022.11.21.514608 — systems biology — Posted on 2024-12-21
1413 Force transmission is a master regulator of mechanical cell competition
Schoenit, A.; Monfared, S.; Anger, L.; Rosse, C.; Venkatesh, V.; Balasubramaniam, L.; Marangoni, E.; Chavrier, P.; Mege, R.-M.; Doostmohammadi, A.; Ladoux, B.
10.1101/2024.12.20.627898 — biophysics — Posted on 2024-12-21
1416 A novel HLA Class II presentation prediction algorithm deciphers immunogenic CD4 epitopes specific to KRAS G12C
Sprague, D.; Hart, M. G.; Klein, J.; Kounlavouth, S.; Vegesna, R.; Rotunno, M.; Kraemer-Tardif, L. D.; Zhou, R.; Kemp, L.; Greeene, A. C.; Araya, J.; Mantilla, A.; Adeoye, B.; Dominguez, C.; Ferguson, A. R.; Johnson, M. L.; Davis, M. J.; Lane, M.; Palmer, C. D.; Jooss, K.; Dhanik, A.
10.1101/2024.12.06.627073 — bioinformatics — Posted on 2024-12-21
1418 Tuning the stability of DNA tetrahedra with base-stacking interactions
Punnoose, J. A.; Cole, D.; Melfi, T.; Morya, V.; Madhanagopal, B. R.; Chen, A. A.; Vangaveti, S. A.; Chandrasekaran, A. R.; Halvorsen, K.
10.1101/2024.06.10.598265 — bioengineering — Posted on 2024-12-21
1420 Deciphering the thiolactonization mechanism in thiolactomycin biosynthesis
Guo, J.; Zhang, Q.; Cheng, F.; Sang, M.; Wang, X.; Yu, H.-B.; Hu, B.; Wang, S.; Zheng, L.; Geng, C.; Yang, C.; Luo, L.; Zhang, G.; Du, L.; Zhang, W.; Wang, B.; Li, S.; Zhang, X.
10.1101/2024.12.18.629141 — biochemistry — Posted on 2024-12-21
1421 Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays
Goldstein, S. I.; Fan, A. C.; Wang, Z.; Naineni, S. K.; Garcia-Gutierrez, S. B.; Cencic, R.; Patel, K.; Huang, S.; Brown, L. E.; Emili, A.; Porco, J. A.
10.1101/2024.04.19.590252 — biochemistry — Posted on 2024-12-21
1423 Dimeric R25CPTH(1-34) Activates the Parathyroid Hormone-1 Receptor in vitro and Stimulates Bone Formation in Osteoporotic Female Mice
Noh, M.; Che, X.; Jin, X.; Lee, D.-K.; Kim, H.-J.; Park, D. R.; Lee, S. Y.; Lee, H.; Gardella, T. J.; Choi, J.-Y.; Lee, S.
10.1101/2024.03.13.584815 — genomics — Posted on 2024-12-21
1426 An in-depth dataset of northwestern European arthropod life histories and ecological traits
Logghe, G.; Batsleer, F.; Maes, D.; Permentier, T.; Berg, M. P.; Brosens, D.; Cooleman, S.; De Smedt, P.; Hagge, J.; Lambrechts, J.; Pollet, M.; Verheyde, F.; Bonte, D.
10.1101/2024.12.17.628846 — ecology — Posted on 2024-12-21
1427 An in-cell approach to evaluate E3 ligases for use in targeted protein degradation.
Zheng, Y.; Singh, A.; Niu, Z.; Marin, V.; Young, J.; Richardson, P.; Hemshorn, M. L.; Cooley, R. B.; Karplus, A. P.; Warder, S.; Vasudevan, A.; Reitsma, J. M.; Mehl, R. A.
10.1101/2024.12.19.629291 — cell biology — Posted on 2024-12-21
1428 Mitochondrial damage triggers therapy-induced senescence
Baltira, C.; Alkan, F.; Mayayo-Peralta, I.; Guillen Navarro, M.; Thijssen, B.; Lempers, R.; Pello, K.; Fedorushkova, D. M.; Their, A.; Jochems, F.; Rozing, K.; Bleijerveld, O.; Janssen, H.; Kuil, L. E.; Beijnen, J. H.; Faller, W. J.; Silva, J.; Bernards, R.; van Tellingen, O.; de Gooijer, M. C.
10.1101/2024.12.20.629667 — cell biology — Posted on 2024-12-21
1431 High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation
Slager, J.; Simpson, H. L.; Gacesa, R.; Chen, L.; Tan, I. L.; Gelderloos, J.; Maatman, A.; Wijmenga, C.; Zhernakova, A.; Fu, J.; Weersma, R. K.; Gonera, G.; Jonkers, I. H.; Withoff, S.
10.1101/2024.03.08.584098 — microbiology — Posted on 2024-12-21
1432 Heterologous immunization strategy developed broadly reactive human monoclonal antibodies against the BK virus
Duty, J. A.; Kraus, T.; Kumar, M.; Tortorella, N. A.; Jimoh, T. O.; Pastrana, D. V.; Buck, C. B.; Moran, T. M.; Tortorella, D.
10.1101/2024.12.18.629307 — microbiology — Posted on 2024-12-21
1433 Temporally overlapping mechanisms diversify clonal B cell responses in vivo.
Skinner, O. P.; Asad, S.; Moreira, M. L.; Lee, H. J.; Williams, C. G.; Li, S.; Jin, W.; Steiner, T. M.; Asatsuma, T.; Lim, J.; Ruan, Z.; Soon, M. S. F.; Engel, J. A.; Khoury, D. S.; Tuong, Z. K.; King, H. W.; Haque, A.
10.1101/2024.12.17.628863 — immunology — Posted on 2024-12-21
1434 Neuropeptide-dependent spike time precision and plasticity in circadian output neurons
Chong, B.; Kumar, V.; Nguyen, D. L.; Hopkins, M. A.; Ferry, F. S.; Spera, L. K.; Paul, E. M.; Hutson, A. N.; Tabuchi, M.
10.1101/2024.10.06.616871 — neuroscience — Posted on 2024-12-21
1435 Sound-Evoked Plasticity Differentiates Tinnitus from Non-Tinnitus Mice
Fabrizio-Stover, E. M.; Lee, C. M.; Oliver, D. L.; Burghard, A. L.
10.1101/2024.12.20.629689 — neuroscience — Posted on 2024-12-21
1438 The genetic architecture of cortical similarity networks
Sebenius, I.; Warrier, V.; Bethlehem, R. A. I.; Dear, R.; Stauffer, E.-M.; Gu, Y.; Romero-Garcia, R.; Seidlitz, J.; Bullmore, E.; Morgan, S. E.
10.1101/2024.12.18.629155 — neuroscience — Posted on 2024-12-21
1441 Hormone-regulated dynamics of mRNA distribution on ribosomes in Sertoli cells
Leray, X.; Morales, J.; Trefier, A.; Leon, K.; Bourquard, T.; Musnier, A.; Pecnard, E.; Drobecq, L.; Boulben, S.; Azzopardi, N.; Coulaud, R.; Ouchene, H.; Jaszczyszyn, Y.; Reiter, E.; Guillou, F.; Pellissier, L. P.; Poupon, A.; Yvinec, R.; Crepieux, P.
10.1101/2024.12.20.629416 — systems biology — Posted on 2024-12-21
1443 Thermodynamic Stability Modulates Chaperone-Mediated Disaggregation of α-Synuclein Fibrils
Fricke, C.; Kunka, A.; Norrild, R. K.; Wang, S.-Y.; Dang, T.-L.; Wentink, A. S.; Bukau, B.; Buell, A. K.
10.1101/2024.12.19.629136 — biophysics — Posted on 2024-12-21
1446 A novel method for integrating genomic and Tn-Seq data to identify common in vivo fitness mechanisms across multiple bacterial species
Fouts, D. E.; Clarke, T. H.; Severin, G. B.; Brown, A. N.; Ottosen, E. N.; Holmes, C. L.; Moricz, B. S.; Mason, S.; Sinha, R.; Anderson, M. T.; DiRita, V.; Bachman, M. A.; Mobley, H. L. T.
10.1101/2024.07.24.604993 — bioinformatics — Posted on 2024-12-21
1447 Dynamic clustering of genomics cohorts beyond race, ethnicity--and ancestry
Mohsen, H.; Blenman, K.; Emani, P. S.; Morris, Q.; Carrot-Zhang, J.; Pusztai, L.
10.1101/2023.08.04.552035 — genomics — Posted on 2024-12-21
1448 Effects of recombination on multi-drug resistance evolution in Plasmodium falciparum malaria
Tran, K. T.; Nguyen, T. D.; Weissman, D. B.; Li, E. Z.; Mok, S.; Small-Saunders, J. L.; Bousema, T.; Zupko, R. J.; Tran, T. N.-A.; Boni, M. F.
10.1101/2024.12.18.628924 — evolutionary biology — Posted on 2024-12-21
1450 G-quadruplex ligand RHPS4 compromises cellular radio-resistance by blocking the increase in mitochondrial mass and activity induced by ionising irradiation.
Tricot, S.; Siberchicot, C.; Bontemps, I.; Desmaze, C.; Kratassiouk, G.; Vandamme, M.; Pinna, G.; Radicella, J. P.; Lenaers, G.; Lebeau, J.; Campalans, A.
10.1101/2024.10.24.619985 — cell biology — Posted on 2024-12-21
1451 cryoTIGER: Deep-Learning Based Tilt Interpolation Generator for Enhanced Reconstruction in Cryo Electron Tomography
Majtner, T.; Kreysing, J. P.; Tuijtel, M. W.; Cruz-Leon, S.; Liu, J.; Hummer, G.; Beck, M.; Turonova, B.
10.1101/2024.12.17.628939 — molecular biology — Posted on 2024-12-21
1452 Yersinia pestis actively inhibits the production of extracellular vesicles by human neutrophils
Sheneman, K. R.; Cummins, T. D.; Merchant, M. L.; Hood, J. L.; Uriarte, S. M.; Lawrenz, M. B.
10.1101/2024.12.20.629761 — microbiology — Posted on 2024-12-21
1453 Systematic functional assessment of antiphage systems in their native host
David, E.; Plantady, C.; Poissonnier, S.; Le Boulch, J.; Gutierrez, A.; Chevallereau, A.
10.1101/2024.12.20.629700 — microbiology — Posted on 2024-12-21
1454 The Porphyromonas gingivalis lipid A 1-phosphatase LpxE has unique features and requires a functional type IX secretion system for its activity
Wang, S.; Liu, Y.; Zhang, B.; Aduse-Opoku, J.; Buccafusca, R.; Mastroianni, G.; Machado, P.; Roberts, M.; Curtis, M. A.; Garnett, J.
10.1101/2024.12.20.629629 — microbiology — Posted on 2024-12-21
1455 Glycosomal phosphoenolpyruvate carboxykinase CRISPR/Cas9-deletion and its role in Trypanosoma cruzi metacyclogenesis and infectivity in mammalian host
Vieira, C. S. D.; Wang, W.; Sanchez-Valdez, F.; Lim, J.; White, B. E.; Garcia, C.; Tarleton, R. L.; Paes, M. C.; Nogueira, N. P.
10.1101/2024.12.20.629751 — microbiology — Posted on 2024-12-21
1456 Discovery and Biosynthesis of Nyuzenamides D and E by Genome Mining in Streptomyces hygroscopicus
Lum, K. Y.; Kumar, R.; Yang, Z.; Souza, L. D. O.; Jarmusch, S. A.; Moreira, J. M. A.; Morth, J. P.; Ding, L.
10.1101/2024.12.20.629799 — microbiology — Posted on 2024-12-21
1457 Big Data, Small Bias: Harmonizing Diffusion MRI-Based Structural Connectomes to Mitigate Site-Related Bias in Data Integration
Shen, R. S.; Parker, D.; Chen, A. A.; Yerys, B. E.; Tunc, B.; Roberts, T. P. L.; Shinohara, R. T.; Verma, R.
10.1101/2024.10.08.617340 — neuroscience — Posted on 2024-12-21
1458 Restoration of locomotor function following stimulation of the A13 region in Parkinson's mouse models
Kim, L. H.; Lognon, A.; Sharma, S. S.; Tran, M. A.; Chomiak, T.; Tam, S.; McPherson, C.; Stang, T. E.; Eaton, S. E.; Kiss, Z. H.; Whelan, P.
10.1101/2023.08.03.551564 — neuroscience — Posted on 2024-12-21
1459 From histology to macroscale function in the human amygdala
Auer, H.; Cabalo, D. G.; Rodriguez-Cruces, R.; Benkarim, O.; Paquola, C.; Dekraker, J.; Wang, Y.; Valk, S. L.; Bernhardt, B.; Royer, J.
10.1101/2024.07.09.602743 — neuroscience — Posted on 2024-12-21
1460 C5aR1 inhibition alleviates cranial radiation-induced cognitive decline
Krattli, R. P.; Do, A. H.; El-Khatib, S. M.; Alikhani, L.; Markarian, M.; Vagadia, A. R.; Usmani, M. T.; Madan, S.; Baulch, J. E.; Clark, R. J.; Woodruff, T. M.; Tenner, A. J.; Acharya, M. M.
10.1101/2024.07.02.601806 — neuroscience — Posted on 2024-12-21
1465 Risk assessment of zoonotic viruses in urban-adapted wildlife
Wei, X.; Li, H.; Huang, Z. Y. X.; Li, S.; Wang, Y.; Lan, J.; Hu, L.; Li, Y.; Becker, D. J.; Wei, F.; Xu, Y.
10.1101/2024.12.18.629064 — ecology — Posted on 2024-12-21
1468 The Soil Microbiome of the Caatinga Drylands in Brazil
Tacca, L. M. A. d.; Lima, R. N.; Oliveira, M. A. d.; Pascoal, P. V.; Bambil, D.; Rosinha, G. M. S.; Signor, D.; Freire, M.; Rech, E.
10.1101/2024.12.20.629793 — microbiology — Posted on 2024-12-21
1470 Anthelmintic resistance against benzimidazoles and macrocyclic lactones in strongyle populations on cattle farms in northern Germany
Ehnert, P.; Kruecken, J.; Fiedler, S.; Horn, S.; Helm, C.; Neubert, A.; Weiher, W.; Terhalle, W.; Steuber, S.; Daher, R.; von Samson-Himmelstjerna, G.
10.1101/2024.12.20.629641 — microbiology — Posted on 2024-12-21
1474 Bounding phenotype transition probabilities via conditional complexity
Dingle, K.; Hagolani, P.; Zimm, R.; Umar, M.; O'Sullivan, S.; Louis, A.
10.1101/2024.12.18.629197 — biophysics — Posted on 2024-12-21
1476 Electron-density informed effective and reliable de novo molecular design and lead optimization with ED2Mol
Li, M.; Song, K.; Zhao, M.; You, G.; Zhong, J.; Zhao, M.; Li, A.; Chen, Y.; Li, G.; Kong, Y.; Wei, J.; Wang, Z.; Zhou, J.; Yang, H.; Ma, S.; Zhang, H.; Melita, I. L.; Lin, W.; Lu, Y.; Yu, Z.; Lu, X.; He, J.; Zhao, Y.; Zhang, J.
10.1101/2024.12.18.629081 — bioinformatics — Posted on 2024-12-21
1479 FibrilPaint to determine the length of Tau amyloids in fluids
Aragones Pedrola, J.; Dekker, F. A.; Garfagnini, T.; Mayer, G.; Koopman, M. B.; Bergmeijer, M.; Forster, F.; Hoozemans, J. J.; Jensen, H.; Friedler, A.; Rudiger, S. G.
10.1101/2023.10.13.562220 — biochemistry — Posted on 2024-12-21
1480 Climate drives long-term landscape and rapid short-term promoter evolution in the Western Canaries lizard, Gallotia galloti
Gilbert, E.; Megia-Palma, R.; Zagar, A.; Lopez-Darias, M.; Carretero, M. A.; Seren, N.; Sellers, G. S.; Beltran-Alvarez, P.; Wollenberg Valero, K. C.
10.1101/2024.12.18.628907 — evolutionary biology — Posted on 2024-12-21
1482 Emerging dynamic regimes and tipping points from finite empirical principles
Cobo-Lopez, S.; Witt, M.; Carbajal, L. J.; Rohwer, F. L.; Luque, A.
10.1101/2023.12.27.573307 — ecology — Posted on 2024-12-21
1483 Restoring Oscillatory Dynamics in Alzheimer's Disease: A Laminar Whole-Brain Model of Serotonergic Psychedelic Effects
Gendra, J. C.; Lopez-Sola, E.; Castaldo, F.; Lleal-Custey, E.; Sanchez-Todo, R.; Vohryzek, J.; Salvador, R.; Andrzejak, R.; Ruffini, G.; Alzheimer's Disease Neuroimaging Initiative,
10.1101/2024.12.15.628565 — neuroscience — Posted on 2024-12-21
1485 Mechanism of catalytic apparatus of human chitotriosidase-1 and its dual inactivation mode by the first-in-class OATD-01 inhibitor.
Niedzialek, D.; Wieczorek, G.; Drzewicka, K.; Antosiewicz, A.; Milewski, M.; Bartoszewicz, A.; Olczak, J.; Zaslona, Z.
10.1101/2024.12.18.628861 — biophysics — Posted on 2024-12-21
1487 Human left ventricle circRNA-miRNA-mRNA network analyses reveals a novel proangiogenic role for circNPHP1 under ischemic conditions
Anwar, M.; Sarkar, M.; Ford, K.; Angelini, G.; Punjabi, P.; Laftah, A.; Chamorro-Jorganes, A.; Ji, J.; Srivastava, P. K.; Petretto, E. G.; Emanueli, C.
10.1101/2024.06.04.597402 — cell biology — Posted on 2024-12-21
1492 Comparison and evaluation of methods to infer gene regulatory networks from multimodal single-cell data
Badia-i-Mompel, P.; Casals-Franch, R.; Wessels, L.; Müller-Dott, S.; Trimbour, R.; Yang, Y.; Ramirez Flores, R. O.; Saez-Rodriguez, J.
10.1101/2024.12.20.629764 — genomics — Posted on 2024-12-21
1493 Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer's disease biomarkers
Tharick, P.; Nedelkov, D.; Matheus, S. R.; Tsokolas, Z. E.; Sible, I.; Han, D.; Yassine, H. N.; Kerman, B. E.; Renteln, M.; Mack, W. J.
10.1101/2024.12.20.629619 — neuroscience — Posted on 2024-12-20
1496 Exploring RNA modifications in infectious non-coding circular RNAs
Vopalensky, P.; Skriba, A.; Chiumenti, M.; Duricekova, L.; Simonova, A.; Luksan, O.; Di Serio, F.; Navarro, B.; Cahova, H.
10.1101/2024.03.12.584625 — biochemistry — Posted on 2024-12-20
1499 The full length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice
Huang, Y.; Bucevic, N.; Coves, C.; Felipe-Medina, N.; Marcet-Ortega, M.; Nikou, N.; Madrid-Sandin, C.; Lopez-Panades, M.; Buza, C.; Ferrer Miralles, N.; Iborra, A.; Pujol, A.; Pendas, A. M.; Roig, I.
10.1101/2024.02.06.579114 — cell biology — Posted on 2024-12-20
1500 Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses
Bartolec, T.; Mitosch, K.; Potel, C.; Corona, F.; Yang, A. L. J.; Burtscher, M. L.; Koumoutsi, A.; Becher, I.; Bobonis, J.; Karcher, N.; Galardini, M.; Typas, A.; Savitski, M. M.
10.1101/2024.12.20.629319 — microbiology — Posted on 2024-12-20
1501 A Brain-Wide Map of Neural Activity during Complex Behaviour
International Brain Lab, ; Benson, B.; Benson, J.; Birman, D.; Bonacchi, N.; Bougrova, K.; Bruijns, S. A.; Carandini, M.; Catarino, J. A.; Chapuis, G. A.; Churchland, A. K.; Dan, Y.; Davatolhagh, F.; Dayan, P.; DeWitt, E. E.; Engel, T. A.; Fabbri, M.; Faulkner, M.; Fiete, I. R.; Findling, C.; Freitas-Silva, L.; Gercek, B.; Harris, K. D.; Hausser, M.; Hofer, S. B.; Hu, F.; Hubert, F.; Huntenburg, J. M.; Khanal, A.; Krasniak, C.; Langdon, C.; Lau, P. Y. P.; Mainen, Z. F.; Meijer, G. T.; Miska, N. J.; Mrsic-Flogel, T. D.; Noel, J.-P.; Nylund, K.; Pan-Vazquez, A.; Paninski, L.; Pouget, A.; Rossan
10.1101/2023.07.04.547681 — neuroscience — Posted on 2024-12-20
1502 CellMemory: Hierarchical Interpretation of Out-of-Distribution Cells Using Bottlenecked Transformer
Wang, Q.; Zhu, H.; Hu, Y.; Chen, Y.; Wang, Y.; Zhang, X.; Zou, J.; Kellis, M.; Li, Y.; Liu, D.; Jiang, L.
10.1101/2024.12.17.628533 — bioinformatics — Posted on 2024-12-20
1504 Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction
Gauderman, W. J.; Fu, Y.; Quem, B.; Kawaguchi, E.; Wang, Y.; Morrison, J.; Brenner, H.; Chan, A.; Gruber, S.; Temitope, K.; Li, L.; Moreno, V.; Pellatt, A.; Peters, U.; Samadder, N. J.; Schmit, S.; Ulrich, C.; Um, C.; Wu, A.; Lewinger, J. P.; Mi, H.; Drew, D.
10.1101/2024.12.16.628610 — genetics — Posted on 2024-12-20
1505 A comprehensive spatiotemporal map of dystrophin isoform expression in the developing and adult human brain
Catapano, F.; Alkharji, R.; Chambers, D.; Singh, S.; Aghaeipour, A.; Malhotra, J.; Ferretti, P.; Phadke, R.; Muntoni, F.
10.1101/2024.12.20.629620 — neuroscience — Posted on 2024-12-20
1509 Whole-genome evaluation of genetic rescue: the case of a curiously isolated and endangered butterfly
MacDonald, Z. G.; Dupuis, J. R.; Glasier, J. R. N.; Sissons, R.; Moehrenschlager, A.; Shaffer, H. B.; Sperling, F. A. H.
10.1101/2024.12.20.627963 — ecology — Posted on 2024-12-20
1511 Silicon-rhodamine-enabled Identification (SeeID) for Near-Infrared Light Controlled Proximity Labeling In Vitro and In Vivo
Wang, W.; Guo, H.; Yan, X.; Pan, X.; Wang, X.; Wu, Z.; Rong, Y.; Zhang, L.; Bai, Z.; Qin, W.; Zhao, X.; Qin, W.; Chu, L.
10.1101/2024.12.19.627432 — molecular biology — Posted on 2024-12-20
1512 The LAMP-CRISPR-Cas13a technique for detecting CBASS-mechanism of phage resistance in bacteria
Ortiz-Cartagena, C.; Fernandez-Grela, P.; Arman, L.; Ibaguren-Quiles, C.; Blasco, L.; Pablo-Marcos, D.; Bleriot, I.; Fernandez-Garcia, L.; Fernandez-Cuenca, F.; Barrio-Pujante, A.; Aracil, B.; Tomas, M.
10.1101/2024.12.19.629325 — microbiology — Posted on 2024-12-20
1517 Food-entrainment of circadian timekeeping in the dorsal vagal complex
Chrobok, L.; Muir, C.; Kaur, T. C.; Veneri, I.; Hitrec, T.; Ambler, M.; Pickering, A. E.; Piggins, H. D.
10.1101/2024.12.20.629643 — neuroscience — Posted on 2024-12-20
1518 Stimulation parameters shape effective connectivity pathways: insights from microstate analysis on TMS-evoked potentials
Lucarelli, D.; Guidali, G.; Sulcova, D.; Zazio, A.; Bonfiglio, N. S.; Stango, A.; Barchiesi, G.; Bortoletto, M.
10.1101/2024.12.18.629242 — neuroscience — Posted on 2024-12-20
1520 Exposure to novel females increases fecundity in adult male prairie voles
Hurd, J.; Watanabe, Y. L.; Toben, G. J.; Ford, A. K.; Miller, C. A.; Sergott, C. E.; Kelley, D.; Donaldson, Z. R.; McCullagh, E. A.
10.1101/2024.12.18.627569 — physiology — Posted on 2024-12-20
1521 Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination
Staples, S. C. R.; Yin, H.; Sutherland, F. S. K.; Prescott, E. K.; Tinney, D.; Hamilton, D. W.; Goldman, D.; Poepping, T. L.; Ellis, C. G.; Pickering, J. G.
10.1101/2024.12.19.627594 — physiology — Posted on 2024-12-20
1522 Mitochondrial ACSS1 regulates the oncometabolite 2-hydroxyglutarate and De Novo Pyrimidine biosynthesis under nutrient-deprived conditions in lymphoma
Basappa, J.; Goldman, A.; Lobello, C.; Wang, S.; Rushmore, D.; Melnikova, O.; Sen, N.; Mallikarjuna, V.; Jain, P.; Edalati, M.; Cai, K.; Lu, P.; Nejati, R.; Borghaei, H.; Wellen, K.; Wasik, M.
10.1101/2024.12.20.628231 — cancer biology — Posted on 2024-12-20
1526 To Peck or Not To Peck: The influence of early-life social environment on response inhibition and impulsive aggression in Japanese quails
Vernouillet, A.; Willcox, K.; Allaert, R.; Dewulf, A.; Zhang, W.; Troisi, C. A.; Knoch, S.; Martel, A.; Lens, L.; Verbruggen, F.
10.1101/2024.12.20.629368 — animal behavior and cognition — Posted on 2024-12-20
1527 The invasions of Aedes aegypti and Aedes albopictus in Cyprus: current situation, risk modelling and public health implications for the wider Eastern Mediterranean region.
Caminade, C.; Vasquez, M. I.; Herodotou, H.; Notarides, G.; Pavlou, C.; Fayad, F.; Papakonstantinou, A.; Violaris, M.; Petric, D.; Mamai, W.; Tompkins, A. M.; Bouyer, J.
10.1101/2024.12.17.628941 — ecology — Posted on 2024-12-20
1529 HIV-SEQ REVEALS GLOBAL HOST GENE EXPRESSION DIFFERENCES BETWEEN HIV-TRANSCRIBING CELLS FROM VIREMIC AND SUPPRESSED PEOPLE WITH HIV
Frouard, J.; Telwatte, S.; Luo, X.; Elphick, N.; Thomas, R.; Arneson, D.; Roychoudhury, P.; Butte, A. J.; Wong, J. K.; Hoh, R.; Deeks, S.; Lee, S.; Roan, N. R.; Yukl, S.
10.1101/2024.12.17.629023 — immunology — Posted on 2024-12-20
1530 Molecular architecture of human dermal sleeping nociceptors
Koerner, J.; Howard, D.; Solinski, H. J.; Moreno, M. M.; Haag, N.; Fiebig, A.; Bhuiyan, S. A.; Toklucu, I.; Bott, R.; Sankaranarayanan, I.; Tavares-Ferreira, D.; Shiers, S.; Inturi, N. N.; Maxion, A.; Ernst, L.; Bonaguro, L.; Schulte-Schrepping, J.; Beyer, M. D.; Stiehl, T.; Renthal, W.; Kurth, I.; Price, T.; Schmelz, M.; Namer, B.; Tripathy, S.; Lampert, A.
10.1101/2024.12.20.629638 — neuroscience — Posted on 2024-12-20
1532 Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome
Proce, R. O.; Uddstrom, E.; Steinecker, M.; Wusthoff, S.; Alves, L. G. T.; Popp, O.; Maxwell, K.; Hortmann, L.; Mertins, P.; Landthaler, M.; Bunina, D.; Hoernberg, H.
10.1101/2024.12.18.628637 — neuroscience — Posted on 2024-12-20
1533 Binding items to contexts through conjunctive neural representations with the Method of Loci
Huang, J.; Manglik, A.; Dutra, N.; Tarder-Stoll, H.; Chamberlain, T. A.; Ajemian, R.; Zhang, Q.; Norman, K. A.; Baldassano, C.
10.1101/2024.12.19.629352 — neuroscience — Posted on 2024-12-20
1534 Does Precision Grip Research Extend to Unconstrained, Multidigit Grasping?
Lepori, F.; Hartmann, F. T.; Dehn, K. I.; Chessa, M.; Fleming, R. W.; Maiello, G.
10.1101/2024.12.20.627508 — neuroscience — Posted on 2024-12-20
1537 Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring
Milosavljevic, S.; Piroli, M. V.; Sandago, E. J.; Piroli, G. G.; Smith, H. H.; Beggiato, S.; Frizzell, N.; Pocivavsek, A.
10.1101/2024.12.18.629210 — neuroscience — Posted on 2024-12-20
1538 The impact of human agents on spatial navigation and knowledge acquisition in a Virtual Environment
Sanchez-Pacheco, T.; Sarria-Mosquera, M.; Gartner, K.; Schmidt, V.; Nolte, D.; Konig, S. U.; Pipa, G.; Konig, P.
10.1101/2024.12.18.628314 — neuroscience — Posted on 2024-12-20
1539 Cortical connectivity, local dynamics and stability correlates of global conscious states
Zhao, Y.; Tsuchiya, N.; Boley, M.; Liu, Y.; Karoly, P.; Pelentritou, A.; Woods, W.; Liley, D.; Kuhlmann, L.
10.1101/2024.12.18.629282 — neuroscience — Posted on 2024-12-20
1542 Postnatal Sensory Experience and Barrel Cortex Alterations Anticipate Autistic Traits in a Mouse Model of Cdkl5 Deficiency Disorder
Raspanti, A.; Pizzo, R.; Gurgone, A.; Giraudo, C.; Sagona, G.; Macioce, A.; Battaglia, A.; Katsanou, L.; Medici, G.; Ferrini, F.; Pizzorusso, T.; Ciani, E.; Giustetto, M.
10.1101/2024.12.20.629347 — neuroscience — Posted on 2024-12-20
1544 Widespread Distribution of α-Synuclein Oligomers in LRRK2-related Parkinson's Disease
Sekiya, H.; Franke, L.; Hashimoto, Y.; Takata, M.; Nishida, K.; Futamura, N.; Hasegawa, K.; Kowa, H.; Ross, O. A.; McLean, P. J.; Toda, T.; Wszolek, Z. K.; Dickson, D. W.
10.1101/2024.12.18.629265 — neuroscience — Posted on 2024-12-20
1545 Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases
Jensen, N. M.; Vitic, Z.; Antorini, M. R.; Bruun Viftrup, T.; Parkkinen, L.; Jensen, P. H.
10.1101/2024.12.20.629583 — neuroscience — Posted on 2024-12-20
1547 Cardiac Pacemaker Cells Harness Stochastic Resonance to Ensure Fail-Safe Operation at Low Rates Bordering on Sinus Arrest
Okamura, A.; He, I. K.; Wang, M.; Maltsev, A. V.; Maltsev, A. V.; Stern, M. D.; Lakatta, E. G.; Maltsev, V. A.
10.1101/2024.12.19.629452 — biophysics — Posted on 2024-12-20
1548 A Framework for Autonomous AI-Driven Drug Discovery
Selinger, D. W.; Wall, T. R.; Stylianou, E.; Khalil, E. M.; Gaetz, J.; Levy, O.
10.1101/2024.12.17.629024 — bioinformatics — Posted on 2024-12-20
1549 Spatial-DC: a robust deep learning-based method for deconvolution of spatial proteomics
Yao, J.; Tian, R.; Li, Y.; Kong, Q.; Wu, Z.; Xu, Y.; Mao, Y.; Gu, Y.; Wang, X.; Gao, W.
10.1101/2024.12.18.629082 — bioinformatics — Posted on 2024-12-20
1553 Genomic Foundationless Models: Pretraining Does Not Promise Performance
Vishniakov, K.; Viswanathan, K.; Medvedev, A.; Kanithi, P.; Pimentel, M. A.; Rajan, R.; Khan, S.
10.1101/2024.12.18.628606 — genomics — Posted on 2024-12-20
1554 Structural Enzymology, Phylogenetics, Differentiation, and Symbolic Reflexivity at the Dawn of Biology
carter, c. W.; Tang, G. Q.; Patra, S. K.; Betts, L.; Dieckhaus, H.; Kuhlman, B.; Douglas, J.; Wills, P.; Bouckaert, R.; Popovic, M.; Ditzler, M.
10.1101/2024.12.17.628912 — evolutionary biology — Posted on 2024-12-20
1557 The effect of an increasing elephant population on the allometry of trees
Thel, L.; Stols, D.; Orth, S.; Lagendijk, D. D. G.; Slotow, R.; Venter, J. A.; Fritz, H.
10.1101/2024.12.18.629108 — ecology — Posted on 2024-12-20
1562 Task and Behavior-Related Variables Are Encoded by the Postrhinal and Medial Entorhinal Cortex During Non-Spatial Associative Learning
Nystuen, I. N.; Rogge, F. S.; Aasen, A. P. H.; Grodem, S.; Malthe-Sorenssen, A.; Lepperod, M. E.; Hafting, T.; Fyhn, M.; Lensjo, K. K.
10.1101/2024.12.20.629630 — neuroscience — Posted on 2024-12-20
1564 Cell type transcriptional identities are maintained in cultured ex vivo human brain tissue
McGinnis, J.; Ortiz-Guzman, J.; Mallannagari, S.; Guevara, M. C.; Belfort, B. D.; Bao, S.; Srivastava, S.; Morkas, M.; Ji, E.; Katlowitz, K. A.; Addison, A.; Tantry, E. K.; Blessing, M. M.; Mohila, C. A.; Gadgil, N.; McClugage, S. G.; Bauer, D. F.; Whitehead, W. E.; Aldave, G.; Tanweer, O.; Jaleel, N.; Jalali, A.; Patel, A. J.; Sheth, S. A.; Weiner, H. L.; Gopinath, S.; Rao, G.; Harmanci, A. S.; Curry, D. J.; Arenkiel, B.
10.1101/2024.12.19.629223 — neuroscience — Posted on 2024-12-20
1565 Neuronal fatty acid oxidation fuels memory after intensive learning
Pavlowsky, A.; Silva, B.; Danglot, L.; Placais, P.-Y.; Preat, T.
10.1101/2024.12.18.629183 — neuroscience — Posted on 2024-12-20
1570 Time-resolved neural and experience dynamics of medium- and high-dose DMT
Lewis-Healey, E.; Pallavicini, C.; Cavanna, F.; D'Amelio, T.; De La Fuente, L. A.; Copa, D.; Muller, S.; Bruno, N.; Tagliazucchi, E.; Bekinschtein, T.
10.1101/2024.12.19.629418 — neuroscience — Posted on 2024-12-20
1571 Visualizing Functional Network Connectivity Differences Using an Explainable Machine-learning Method
Sendi, M. S. E.; Itkyal, V. S.; Edwards-Swart, S. J.; Chun, J. Y.; Mathalon, D. H.; Ford, J. M.; Preda, A.; van Erp, T. G. M.; Pearlson, G. D.; Turner, J. A.; Calhoun, V. D.
10.1101/2024.12.18.629283 — neuroscience — Posted on 2024-12-20
1572 Frequency-tagged fMRI: A platform for fine-grained spatiotemporal analysis of cortical function
Ngo, G. N.; Rafeh, R. W.; Muller, L. E.; Khan, A. R.; Menon, R. S.; Schmitz, T. W.; Mur, M.
10.1101/2024.12.19.629518 — neuroscience — Posted on 2024-12-20
1575 Large-scale infra-slow dynamics of extracellular potentials linked to synchronous states revealed by graphene neural probes
Garcia-Cortadella, R.; Cisneros-Fernandez, J.; Schwesig, G.; Shahidi, A.; Umurzakova, A.; Schaefer, N.; Aguilar, J.; Masvidal-Codina, E.; Del Corro, E.; Mohrlok, R.; Kurnoth, M.; Paetzold, J.; Jeschke, C.; Loeffler, H.; Meents, J.; Illa, X.; Serra-Graells, F.; Guimera-Brunet, A.; Garrido, J. A.; Sirota, A.
10.1101/2024.12.20.629545 — neuroscience — Posted on 2024-12-20
1579 Radiation damage behavior of soft matter in ultrafast cryo-electron microscopy (cryo-UEM)
Zhao, Y.; Qi, C.; Zhu, C.; Zhu, Y.; Zhang, Y.; Gu, T.; Tian, H.; Wang, W.; Huang, S.; Yang, H.; Li, J.; Sun, F.
10.1101/2024.12.20.629524 — biophysics — Posted on 2024-12-20
1588 Wireless bioelectronic device for wound healing
Baniya, P.; Tebyani, M.; Hee, W. S.; Li, H.; Asefifeyzabadi, N.; Yang, H.-y.; Zhu, K.; Keller, G.; Franco, C.; Schorger, K.; Devarajan, K.; Barbee, A.; Hernandez, C.; Nguyen, T.; Lu, F.; Gallegos, A.; Recendez, C.; Isseroff, R. R.; Zhao, M.; Gomez, M.; Rolandi, M.; Teodorescu, M.
10.1101/2024.12.18.629068 — biochemistry — Posted on 2024-12-20
1591 Deaminase-mediated chromatin accessibility profiling with single-allele resolution
Yu, T.; Li, Z.; Gibbs, E.; Iwase, R.; Francoeur, M. J.; Phan, Q. v.; Zhao, J.; Rosin, J.; Cole, P. A.; Pinello, L.; Sherwood, R. I.
10.1101/2024.12.17.628768 — genomics — Posted on 2024-12-20
1592 Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in a rotenone rat model of Parkinson's disease
Tsalenchuk, M.; Farmer, K.; Castro, S.; Scheirer, A.; Ye, Y.; Greenamyre, J. T.; Rocha, E. M.; Marzi, S. J.
10.1101/2024.12.17.628873 — genomics — Posted on 2024-12-20
1593 Chromatin accessibility classification of TAD boundaries discloses new architectural proteins
Jacome-Lopez, K.; Ledesma-Dominguez, L.; Esquivel-Lopez, A.; Perez-Molina, R.; Penagos-Puig, A.; Aguilar-Lomas, A.; Furlan-Magaril, M.
10.1101/2024.12.18.629025 — genomics — Posted on 2024-12-20
1594 Androgen stimulation rapidly reorganizes temporal 3D genome and epigenome states to trigger AR-mediated transcription in prostate cancer.
Campbell, E. M.; Laven-Law, G.; Smith, G.; Peters, T. J.; Sanguino, Y. C.; Moulder, D.; Du, Q.; Jones, A.; Giles, K.; Khoury, A.; Stirzaker, C.; Hickey, T.; Mora, F. V.; Clark, S.; Achinger-Kawecka, J.
10.1101/2024.12.17.628805 — genomics — Posted on 2024-12-20
1599 Silent reservoirs are shaping disease emergence: the case of Usutu virus in the Netherlands
de Wit, M. M.; Beaunee, G.; Dellar, M.; Munger, E.; Krol, L.; Atama, N.; van Irsel, J.; van der Jeugd, H. P.; Koopmans, M.; De Jong, M. C. M.; Sikkema, R.; ten Bosch, Q.
10.1101/2024.12.17.628855 — ecology — Posted on 2024-12-20
1601 Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos
Zilliox, M.; Letort, G.; Sanchez, D.; Rouviere, C.; Dufourcq, P.; Gaits-Iacovoni, F.; Pizzoccaro, A.; Roussier-Michon, V.; Blader, P.; Batut, J.
10.1101/2024.12.20.629493 — developmental biology — Posted on 2024-12-20
1603 PPARδ restrains the suppression function of intra-tumoral Tregs by limiting CIITA-MHC II expression
Yang, Q.; Liang, Y.; Inoue-Hatanaka, T.; Koh, Z.; Ilkenhans, N.; Suman, E.; Yu, J.; Zheng, Y.
10.1101/2024.12.16.628819 — immunology — Posted on 2024-12-20
1605 Ready-to-load MHC-I Nanoparticles for High-throughput T cell Screening Studies
Phan, H. A. T.; Hwang, D.; Young, M. C.; Sun, S. M.; Monos, D. S.; Sgourakis, N. G.
10.1101/2024.12.17.628918 — immunology — Posted on 2024-12-20
1608 Structural and genetic determinants of zebrafish functional brain networks
Legare, A.; Lemieux, M.; Boily, V.; Poulin, S.; Legare, A.; Desrosiers, P.; De Koninck, P.
10.1101/2024.12.20.629476 — neuroscience — Posted on 2024-12-20
1609 Identifying the Brain Circuits that Regulate Pain-Induced Sleep Disturbances
Lynch, N.; De Luca, R.; Spinieli, R. L.; Rillosi, E.; Thomas, R. C.; Sailesh, S.; Gangeddula, N.; Lima, J. D.; Bandaru, S.; Arrigoni, E.; Burstein, R.; Thankachan, S.; Kaur, S.
10.1101/2024.12.20.629596 — neuroscience — Posted on 2024-12-20
1610 Cleavage of the TrkB-FL Receptor During Epileptogenesis: Insights from a Kainic Acid-Induced Model of Epilepsy and Human Samples
Ribeiro-Rodrigues, L.; Fonseca-Gomes, J.; Paulo, S. L.; Viais, R.; Ribeiro, F. F. F.; Miranda-Lourenco, C.; Mouro, F. M.; Belo, R. F.; Ferreira, C. B.; Tanqueiro, S. R.; Fereira-Manso, M.; Umemori, J.; Castren, E.; Paiva, V. H.; Sebastiao, A. M.; Aronica, E.; Rainha Campos, A.; Bentes, C.; Xapelli, S.; Diogenes, M. J.
10.1101/2024.12.18.628660 — neuroscience — Posted on 2024-12-20
1611 Neddylation regulates the development and function of excitatory neurons
Torres, J.; Vural, Z.; Fiosins, M.; Benseler, F.; Bonn, S.; Rizzoli, S.; Rhee, J.; Brose, N.; Tirard, M.
10.1101/2024.12.18.629191 — neuroscience — Posted on 2024-12-20
1612 Uncovering sex differences in Parkinson's Disease through metaanalysis of single cell transcriptomic studies
Gordillo-Gonzalez, F.; Soler-Saez, I.; Galiana-Rosello, C.; Hidalgo, M. R.; Gomez-Cabanes, B.; Grillo-Risco, R.; Dolader-Rabinad, B.; del Rey-Diez, N.; Virues-Morales, A.; Yanguas-Casas, N.; Casanova-Ferrer, F.; Garcia-Garcia, F.
10.1101/2024.12.20.628852 — neuroscience — Posted on 2024-12-20
1613 Endocrine modulation of cortical and retinal blood flow across the menstrual cycle
Wright, M. E.; Crofts, A.; Davies, S.; Chandler, H. L.; Driver, I. D.; Germuska, M.; Giarratano, Y.; Rashid, D.; Bernabeu, M. O.; Terry, L.; Steventon, J. J.; Murphy, K.
10.1101/2024.12.19.629235 — neuroscience — Posted on 2024-12-20
1617 A FRET-Based FLIM Method to Probe Membrane-Induced Alpha-Synuclein Aggregation in Neurons
Ivey, P. M. E.; Salem, A.; Min, S.; Qi, W.; Guzman Sosa, M.; Kinzer-Ursem, T. L.; Rochet, J.-C.; Webb, K. J.
10.1101/2024.12.19.629536 — neuroscience — Posted on 2024-12-20
1618 A Leadfield-Free Optimization Framework for Transcranially Applied Electric Currents
Weise, K.; Madsen, K. H.; Worbs, T.; Knoesche, T. R.; Korshoej, A.; Thielscher, A.
10.1101/2024.12.18.629095 — neuroscience — Posted on 2024-12-20
1619 Ongoing loss of viable neurons for weeks after mild perinatal hypoxia-ischemia
McNally, M.; Lau, L. A.; Granak, S.; Hike, D.; Liu, X.; Yu, X.; Donahue, R.; Chibnik, L.; Ortiz, J.; Che, A.; Northington, F.; Staley, K. J.
10.1101/2024.12.19.629457 — neuroscience — Posted on 2024-12-20
1620 Artificial Embodied Circuits Uncover Neural Architectures of Vertebrate Visuomotor Behaviors
Liu, X.; Loring, M. D.; Zunino, L.; Fouke, K. E.; Longchamp, F. A.; Bernardino, A.; Ijspeert, A. J.; Naumann, E. A.
10.1101/2024.12.19.629427 — neuroscience — Posted on 2024-12-20
1622 Incomplete adaptation to surface movement during hand reaching
Balestrucci, P.; Bianchi, M.; Ryan, C. P.; Daniele, G.; Flamini, A.; Valente, F.; Lacquaniti, F.; Moscatelli, A.
10.1101/2024.12.18.629126 — neuroscience — Posted on 2024-12-20
1624 DeepMapper: Attention-Based AutoEncoder for System Identification in Wound Healing and Stage Prediction
Lu, F.; Zlobina, K.; Osorio, S.; Yang, H.; Nava, A.; Bagood, M.; Rolandi, M.; Isseroff, R.; Gomez, M.
10.1101/2024.12.17.628977 — systems biology — Posted on 2024-12-20
1625 Mathematical Models of Retinal Drug Delivery
Roberts, P. A.; Thomas, C. N.; Bellamy Plaice, G.; Roberts, J. A.; Jones, M.-C.; Andrews, J. W.; Hill, L. J.
10.1101/2024.12.17.629033 — systems biology — Posted on 2024-12-20
1628 The RING-finger domain of Arabidopsis RMR functions as an E3 ligase essential for post-Golgi trafficking
Chen, S.; Zeng, Y.; Wong, H.; Chen, Y.; Yang, L.; Luo, F.; Gao, C.; Jiang, L.; Wong, K.-B.
10.1101/2024.12.17.628466 — plant biology — Posted on 2024-12-20
1630 Lotus japonicus VIH2 is an inositol pyrophosphate synthase that regulates arbuscular mycorrhiza
Raj, K.; Gaugler, V.; Lu, M.; Schaedel, M.; Gaugler, P.; Grothaus, C. M. M.; Jochimsen, U. A.; Liu, G.; Harings, M.; Jessen, H. J.; Schaaf, G.; Ried-Lasi, M. K.
10.1101/2024.12.17.628921 — plant biology — Posted on 2024-12-20
1633 Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies
Ojala, V. K.; Ahonen, S.; Tuohisto-Kokko, A.; Esparta, O.; Suominen, P.; Jokilammi, A.; Farahani, I.; Chakroborty, D.; Dibus, N.; Boettcher, S.; Airenne, T. T.; Johnson, M. S.; Eli, L. D.; Elenius, K.; Kurppa, K. J.
10.1101/2024.12.19.626686 — cancer biology — Posted on 2024-12-20
1644 Detecting Amino Acid Variants Using Next-Generation Protein Sequencing (NGPS)
Chinnaraj, M.; Lin, J.; Blacklock, K.; Hermes, E.; Meyer, M.; Pike, D.; Vieceli, J.; Chorny, I.
10.1101/2024.12.17.629036 — bioinformatics — Posted on 2024-12-20
1645 Accurate calling of low-frequency somatic mutations by sample-specific modeling of error rates
Lin, Y.; Oroperv, C.; Porsborg, P. S.; Frydendahl, A.; Rasmussen, M. H.; Bataillon, T.; Schierup, M.; Andersen, C. L.; Almstrup, K.; Besenbacher, S.
10.1101/2024.12.17.629019 — bioinformatics — Posted on 2024-12-20
1647 Lipid Nanoparticle Barcoding for Multiplexed Single-Cell RNA Sequencing
Feng, Y.; Chen, D.; Applegate, C. C.; Gonzalez Medina, N. Y.; Kuo, C.-W.; Arogundade, O. H.; Wright, C. L.; Xu, F.; Drnevich, J.; Smith, A. M.
10.1101/2024.12.16.628827 — bioengineering — Posted on 2024-12-20
1648 Response of Serum-isolated Extracellular Vesicles to Focused Ultrasound Blood-Brain Barrier Opening
Kline-Schoder, A. R.; Tsitsos, F. N.; Batts, A. J.; DiBenedetto, M. R.; Liu, K.; Bae, S.; Konofagou, E. E.
10.1101/2024.12.17.629012 — bioengineering — Posted on 2024-12-20
1649 Small molecule activation of the tumor suppressor kinase LKB1
Kretschmer, L. S.; Mitchell, D. C.; Liu, J.; Wang, L.; Wang, Z.; He, C.; Ding, L.; Adler, M.; Turnham, R. E.; Kellett, T.; Keith, A.; Hwang, Y. C.; Chan, G. K. L.; Li, W.; Ramamoorthi, R.; Lively, S.; Drakas, R. A.; Ramani, V.; Qing, T.; Verba, K. A.; Ostrem, J. M. L.; Beresis, R. T.; Gordan, J. D.
10.1101/2024.12.17.628051 — biochemistry — Posted on 2024-12-20
1651 Interindividual variability in flower pickiness by foraging bumblebees
Armand, M.; Beckenbauer, C.; Avargues-Weber, A.; Lihoreau, M.; Czaczkes, T. J.
10.1101/2024.12.19.629386 — animal behavior and cognition — Posted on 2024-12-20
1656 Comparative atlas of genome-wide chromatin-associated protein co-occupancy
White, S. M.; Moyers, B. A.; Wang, T.; Mackiewicz, M.; Weimer, A. K.; Grubert, F.; Ramalingam, V.; Luo, J. X. J.; Jiang, L.; Shi, M.; Yang, X.; Chou, T.; Zhai, J.; Von Kraut, K.; Adrian, J.; Partridge, E. C.; Paul, K.; Kundaje, A.; Mendenhall, E. M.; Myers, R. M.; Snyder, M. P.
10.1101/2024.12.17.628199 — genomics — Posted on 2024-12-20
1659 Improving whole biodiversity monitoring and discovery with environmental DNA metagenomics
Curto, M. A. C.; Verissimo, A.; Riccioni, G.; Santos, C. D.; Ribeiro, F.; Jentoft, S.; Alves, M. J.; Gante, H. F.
10.1101/2024.12.17.628643 — ecology — Posted on 2024-12-20
1661 Differential aggregation patterns of Endozoicomonas within tissues of the coral Acropora loripes
Gotze, C. R.; Dungan, A. M.; van de Meene, A.; Damjanovic, K.; Philip, G. K.; Maire, J.; Hoj, L.; Blackall, L.; van Oppen, M. J.
10.1101/2024.12.17.629048 — ecology — Posted on 2024-12-20
1662 Loss of olfaction reduces caterpillar performance and increases susceptibility to a natural enemy
Wang, Q.; Jia, Y.; Smid, H.; Weldegergis, B.; Greenberg, L.; Jongsma, M.; Dicke, M.; Haverkamp, A.
10.1101/2024.12.17.629055 — ecology — Posted on 2024-12-20
1663 Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
Tsissios, G.; Leleu, M.; Hu, K.; Demirtas, A. E.; Hu, H.; Kawanishi, T.; Skoufa, E.; Valente, A.; Herrera, A.; Mery, A.; Noseda, L.; Ochi, H.; Sakar, S.; Tanaka, M.; Zenk, F.; Aztekin, C.
10.1101/2024.12.19.629359 — developmental biology — Posted on 2024-12-20
1664 Left-right cortical interactions drive intracellular pattern formation in the ciliate Tetrahymena
Lee, C.; Joachimiak, E.; Maier, W.; Jiang, Y.-Y.; Lechtreck, K.; Cole, E. S.; Gaertig, J.
10.1101/2024.12.18.629246 — cell biology — Posted on 2024-12-20
1666 A comprehensive benchmark for multiple highly efficient base editors with broad targeting scope
Wang, X.; Cheng, X.; Li, Z.; Ma, S.; Zhang, H.; Chen, Z.; Yao, Y.; Li, Z.; Zhong, C.; Li, Y.; Zhang, Y.; Menon, V.; Chao, L.; Li, W.; Fei, T.
10.1101/2024.12.17.628899 — molecular biology — Posted on 2024-12-20
1667 Identification of strain-specific cues that regulate biofilm formation in Bacteroides thetaiotaomicron
Glowacki, R. W. P.; Engelhart, M. J.; Till, J. M.; Kadam, A.; Nemet, I.; Sangwan, N.; Ahern, P. P.
10.1101/2024.12.20.629428 — microbiology — Posted on 2024-12-20
1668 AMPK acts to remove immune barriers to CD8+ T cell-mediated immunity against hepatocellular carcinoma
Hu, H.-H.; Wang, X.; Lan, B.; Cheng, H.; Wen, H.; Chen, F.; Wu, J.; Li, M.; Chen, J.; Chen, D.; Lin, S.; Yang, M.; Wu, Z.; Zheng, Z.-Z.; Chen, F.; Zhou, J.; Chen, G.; Chen, Y.; Deng, X.; Zhang, C.-S.; Liu, J.; Lin, S.-C.
10.1101/2024.12.16.628539 — immunology — Posted on 2024-12-20
1669 Characterisation of transgenic lines labelling reticulospinal neurons in larval zebrafish
Collins, E. M.; Silva, P. T.; Ostrovsky, A. D.; Renninger, S. L.; Tomas, A. R.; Diez del Corral, R.; Orger, M. B.
10.1101/2024.12.20.629714 — neuroscience — Posted on 2024-12-20
1670 Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication
Plaisier, F.; Ibaceta-Gonzalez, C.; Khelfaoui, H.; Watson, A. E. S.; Poilbout, C.; Voronova, A.; Angulo, M. C.
10.1101/2024.12.19.629474 — neuroscience — Posted on 2024-12-20
1673 The proteasome activator PA200 regulates tumor cell invasion
Yazgili, A. S.; Zivkovic, D.; Sanchez Dafun, A.; Giotopoulou, G. G.; Behrend, S.; Koops, F.; Zemke, L.; Stacher-Priehse, E.; Goldmann, T.; Reiling, N.; Stathopoulos, G. T.; Marcoux, J.; Bousquet, M.-P.; Meiners, S.
10.1101/2024.12.17.628836 — cancer biology — Posted on 2024-12-20
1675 Time-resolved fluorescent proteins towards fluorescence microscopy in the temporal and spectral domains
Tan, Z.; Hsiung, C.-H.; Feng, J.; Zhang, Y.; chen, J.; Sun, K.; Lu, P.; Zang, J.; Yang, W.; Gao, Y.; Yin, J.; Zhu, T.; Ye, Y.; Wan, Y.; Zhang, X.
10.1101/2024.12.16.628778 — biochemistry — Posted on 2024-12-20
1676 Isolation of a novel Sphingomonas strain able to degrade the pleuromutilin tiamulin: omic analysis reveals its transformation pathway
Perruchon, C.; Tagkalidou, N.; Kalogiouri, N.; Katsivelou, E.; Karas, P.; Menkissoglu-Spiroudi, U.; Vasileiadis, S.; Karpouzas, D. G.
10.1101/2024.12.16.628731 — genomics — Posted on 2024-12-20
1677 Transcriptomic plasticity in hybrid schistosomes can contribute to their zoonotic potential
Toulza, E.; Boissier, J.; Rey, O.; Rognon, A.; Chaparro, C.; Allienne, J.-F.; Kincaid-Smith, J.; Mathieu-Begne, E.; Luviano, N.; Picard, M.; Polack, B.; Vallee, I.; Thomas, M.; Fontaine, J.-J.
10.1101/2024.12.16.628740 — evolutionary biology — Posted on 2024-12-20
1680 Early Neolithic forest farming at Seven Springs, Martlesham, Suffolk inferred from sedaDNA and pollen
Hudson, S. M.; Allen, S. J.; Alsos, I. G.; Curl, J.; Heintzman, P. D.; Hughes, P.; Gardiner, L.; Lloyd-Smith, L.; Pears, B. R.; Scaife, R.; Stoof-Leichsenring, K. R.; Brown, A.
10.1101/2023.10.11.561859 — ecology — Posted on 2024-12-20
1682 BACH2-driven tissue resident memory programs promote HIV-1 persistence
Wei, Y.; Ma, H. K.; Wang, M. E.; Papasavvas, E.; Konnikova, L.; Tebas, P.; Morgenstern, R.; Montaner, L. J.; Ho, Y.-C.
10.1101/2024.12.16.628794 — immunology — Posted on 2024-12-20
1685 IL-17A primes an early progenitor compartment to tune the erythropoietic feedback circuit
Wu, Q. C.; Swaminathan, A.; Winward, A.; Lalonde, L.; Hwang, Y.; Littman, N.; Socolovsky, M.; Klein, A. M.
10.1101/2024.12.16.628761 — systems biology — Posted on 2024-12-20
1688 An opioid efficacy switch for reversible optical control of peripheral analgesia
Posa, L.; Romano, G.; Ji, X.; Khan, S.; Paz, B.; Han, G. W.; Nazarova, A. L.; Zaidi, S. A.; Ranjbar, M.; Pleil, K. E.; Katritch, V.; Gati, C.; Trauner, D.; Levitz, J.
10.1101/2024.12.16.628735 — pharmacology and toxicology — Posted on 2024-12-20
1689 Cell-cell communication controls the timing of gastruloid symmetry-breaking
Oriola, D.; Torregrosa-Cortes, G.; Arato, K.; Fernandez-Munuera, D.; Hahn, E. M.; Anlas, K.; Garcia-Ojalvo, J.; Trivedi, V.
10.1101/2024.12.16.628776 — biophysics — Posted on 2024-12-20
1690 Capturing the Conformational Heterogeneity of HSPB1 Chaperone Oligomers at Atomic Resolution
Berkeley, R. F.; Plonski, A. P.; Phan, T.; Grohe, K.; Becker, L.; Wegner, S.; Herzik, M. A.; Mittal, J.; Debelouchina, G. T.
10.1101/2024.12.16.628790 — biophysics — Posted on 2024-12-20
1694 Temporal Parameters Determine the Efficacy of Vagus Nerve Stimulation Directed Neural Plasticity
Addo, J. J. A.; Neifert, C. L.; Danaphongse, T.; Abe, S.; Ezhil, V.; Kilgard, M. P.; Hays, S. A.
10.1101/2024.12.16.628694 — bioengineering — Posted on 2024-12-20
1696 Enabling Hydrogel Coating on Silicone Breast Implants with Poly(Vinyl Acetate) Primer Layer
Stanger, K.; Bajrami, D.; Wahl, P.; Moriaty, F.; Gautier, E.; Dommann, A.; Wei, K.
10.1101/2024.12.16.628176 — bioengineering — Posted on 2024-12-20
1697 Formulation, Characterization, and in vivo Immunogenicity of Heat-Stabilized Dissolvable Microneedles Containing a Novel VLP Vaccine
Muttil, P.; Leyba, A. L.; Francian, A.; Razmjoo, M.; Bierle, A.; Janardhana, R. D.; Jackson, N.; Chackerian, B.
10.1101/2024.12.16.628763 — bioengineering — Posted on 2024-12-20
1698 Pyrophosphate-containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality
Jolic, M.; Aberg, I.; Omar, O.; Engqvist, H.; Engstrand, T.; Palmquist, A.; Thomsen, P.; Shah, F. A.
10.1101/2024.12.16.628729 — bioengineering — Posted on 2024-12-20
1700 Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control
Grabarczyk, D. B.; Ehrmann, J. F.; Murphy, P.; Kurzbauer, R.; Bell, L. E.; Deszcz, L.; Neuhold, J.; Schleiffer, A.; Shulkina, A.; Versteeg, G. A.; Meinhart, A.; Zavodszky, E.; Hegde, R. S.; Clausen, T.
10.1101/2024.12.18.629163 — biochemistry — Posted on 2024-12-20
1702 Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across Africa
White, N. F. D.; Whitton, G.; Wasakul, V.; Amenga-Etego, L.; Dara, A.; Andrianaranjaka, V.; Randrianarivelojosia, M.; Miotto, O.; D'Alessandro, U.; Djimde, A.; Ariani, C. V.; Pearson, R. D.; Amambua-Ngwa, A.
10.1101/2024.12.16.628681 — genomics — Posted on 2024-12-20
1705 A modelling framework to estimate vector dispersal and disease spread in an important agricultural pathosystem
Preedy, K. F.; McNamara, L.; Mostafiz, M. M.; Schughart, M.; Bramham, L. E.; Leybourne, D. J.
10.1101/2024.12.16.628743 — ecology — Posted on 2024-12-20
1707 The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection
Kozawa, F.; Tamura, T.; Takahashi, N.; Kakizuka, T.; Ichimura, T.; Shimada, R.; Hashimoto, Y.; Onituska, H.; Kashiwagi, S.; Kamasaki, T.; Amano, M.; Nagai, T.; Fukuhara, T.; Fujioka, Y.; Ohba, Y.
10.1101/2024.12.20.629723 — cell biology — Posted on 2024-12-20
1709 Type IV pili-associated secretion of a biofilm matrix protein from Clostridium perfringens that forms intermolecular isopeptide bonds
Kivimaki, S. E.; Dempsey, S.; Camper, C.; Tani, J. M.; Hicklin, I. K.; Blaby-Haas, C. E.; Brown, A. M.; Melville, S. B.
10.1101/2024.11.04.621531 — microbiology — Posted on 2024-12-20
1711 De novo design and structure of a peptide-centric TCR mimic binding module
Householder, K. D.; Xiang, X.; Jude, K. M.; Deng, A.; Obenaus, M.; Wilson, S. C.; Chen, X.; Wang, N.; Garcia, K. C.
10.1101/2024.12.16.628822 — immunology — Posted on 2024-12-20
1712 Immunometabolic analysis of primary murine Group 2 Innate Lymphoid Cells: a robust step-by-step approach
Krisna, S. S.; Deagle, R. C.; Ismailova, N.; Esomojumi, A.; Roy-Dorval, A.; Roth, F.; Berberi, G.; Del Rincon, S. V.; Fritz, J. H.
10.1101/2024.12.16.628689 — immunology — Posted on 2024-12-20
1714 Immuno-moodulin is Differentially Expressed in T Cells and Plasma in Obsessive-Compulsive Disorder Patients
Blacksell, I. A.; Vismara, M.; Lim, C. M.; Dell'Osso, B.; Pallanti, S.; Hollander, E.; Vendruscolo, M.; D'Addario, C.; Cooper, D.; D'Acquisto, F.
10.1101/2024.12.16.628685 — immunology — Posted on 2024-12-20
1716 APOE4 alters the lipid droplet proteome and modulates droplet dynamics
Friday, C. M.; Stephens, I. O.; Smith, C. T.; Lee, S.; Satish, D.; Devanney, N. A.; Cohen, S.; Morganti, J. M.; Gordon, S. M.; Johnson, L. A.
10.1101/2024.12.16.628710 — physiology — Posted on 2024-12-20
1717 Investigating BPDE-induced embryonic toxicity employing hiPSC-based models
Meira de Amorim, V. C.; Lofrano, A.; Szepanowski, L.-P.; Loerch, C. C.; Wruck, W.; Graffmann, N.; Adjaye, J.
10.1101/2024.12.16.628678 — pharmacology and toxicology — Posted on 2024-12-20
1718 Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo
Smith, E. R.; Turner, E. D.; Abdelhamid, M. A. S.; Craggs, T. D.; Twelvetrees, A. E.
10.1101/2024.12.20.629623 — biophysics — Posted on 2024-12-20
1719 Honest signalling in predator-prey interactions: testing the resource allocation hypothesis
Burdfield-Steel, E.; Ottocento, C.; Furlanetto, M.; Rojas, B.; Nokelainen, O.; Mappes, J.
10.1101/2024.12.06.627197 — evolutionary biology — Posted on 2024-12-20
1720 Drosophila melanogaster pigmentation demonstrates adaptive phenotypic parallelism over multiple timescales
Berardi, S.; Rhodes, J. A.; Berner, M. C.; Greenblum, S. I.; Bitter, M. C.; Behrman, E. L.; Betancourt, N. J.; Bergland, A. O.; Petrov, D. A.; Rajpurohit, S.; Schmidt, P.
10.1101/2024.08.09.607378 — evolutionary biology — Posted on 2024-12-20
1723 Performance of eDNA capture methods for monitoring fish biodiversity in a hyper-tidal estuary
Jackman, J. M.; Sales, N. G.; Benvenuto, C.; Drewitt, A.; Wolfenden, A.; Robins, P.; Coscia, I.; McDevitt, A.
10.1101/2024.12.20.629404 — molecular biology — Posted on 2024-12-20
1725 Horizontal gene transfers and terpene metabolism drive plant-fungal interaction in Marchantia polymorpha
El Mahboubi, K.; Beaulieu, C.; CASTEL, B.; Libourel, C.; JARIAIS, N.; Amblard, E.; van Beveren, F.; Keller, J.; Martinez, Y.; Nelson, J.; Bonhomme, M.; Jacquet, C.; Delaux, P.-M.
10.1101/2024.12.20.629586 — plant biology — Posted on 2024-12-20
1726 Amyloid forming human lysozyme intermediates are stabilised by non-native amide-π interactions
Ahn, M.; Streit, J. O.; Waudby, C. A.; Włodarski, T.; Miguel Figueiredo, A.; Christodoulou, J.; Kumita, J. R.
10.1101/2024.12.20.629167 — biophysics — Posted on 2024-12-20
1727 Supervised non-negative matrix factorization on cell-free DNA fragmentomic features enhances early cancer detection
Tran, T. H.; Pham, N. T.; Nguyen, V. T. C.; Vo, D. H.; Nguyen, T. H. H.; Tran, T. T.; Tran, T. T.; Vo, T. D. H.; Dao, T. H.; Nguyen, H. T. P.; Phan, T. V.; Ha, T. M. T.; Ngo, T. D. H.; Tran, N.-H.; Tran, N.-T.; Hoang, T. Q.; Nguyen, V. B.; Le, V. C.; Nguyen, X. C.; Nguyen, T. M. P.; Nguyen, V. H.; Tran, N. T. N.; Dang, T. N. Q.; Tran, M. H.; Nguyen, P. N.; Pham, T. A. T.; Vo, D. L.; Doan, T. N.; Nguyen, V. H.; Tran, Q. D.; Dang, Q. T.; Ho, L. M. Q.; Nguyen, V. T. A.; Nguyen, S. T.; Nguyen, H.-N.; Tran, L. S.; Giang, H.; Phan, M. D.; Nguyen, T. H.
10.1101/2024.12.20.629316 — bioinformatics — Posted on 2024-12-20
1729 Three-dimensional regulatory hubs support oncogenic programs in glioblastoma
Breves, S. L.; Campigli Di Giammartino, D.; Nicholson, J.; Cirigliano, S.; Mahmood, S. R.; Lee, U. J.; Martinez-Fundichely, A.; Jungverdorben, J.; Singhania, R.; Rajkumar, S.; Kirou, R.; Studer, L.; Khurana, E.; Polyzos, A.; Fine, H. A.; Apostolou, E.
10.1101/2024.12.20.629544 — genomics — Posted on 2024-12-20
1732 TEAD promotes lineage progression of subpallial neural progenitor cells independent of YAP/TAZ
Perry, C. H.; Lavado, A.; Thulabandu, V.; Ramirez, C.; Pare, J.; Dixit, R.; Mishra, A.; Yang, J.; Yu, J.; Cao, X.
10.1101/2024.12.19.629472 — developmental biology — Posted on 2024-12-20
1735 Chemical degradation identified Human p38-MAPK as a host target to combat parasitic infections
Singhal, J.; Rawat, N.; Bansal, R.; Srivastava, P.; Ghousepeer, G. D.; Pandey, R. P.; Ranganathan, A.; Singh, S.
10.1101/2024.12.19.629355 — microbiology — Posted on 2024-12-20
1736 Candida albicans a comprehensive view of the proteome
Gomez Artiguez, L.; de la Camara Fuentes, S.; Sun, Z.; Hernaez-Sanchez, M. L.; Borrajo, A.; Pitarch, A.; Molero, G.; Monteoliva Diaz, L.; Moritz, R. L.; Deutsch, E. W.; Gil, C.
10.1101/2024.12.20.629377 — microbiology — Posted on 2024-12-20
1737 Nebulized 2-deoxylated glucose analogues inhibit respiratory viral infection in advanced in vitro airway models
Wideman, S. K.; Wali, L. K.; Kovtunyk, V.; Chou, S.; Gussel, V.; Telimaa, H.; Najmi, C.; Stoeva, D.; Stoeckl, J.; Gualdoni, G. A.; Gorki, A.-D.; Radivojev, S.
10.1101/2024.12.20.629606 — microbiology — Posted on 2024-12-20
1742 The conserved global regulator H-NS has a strain-specific impact on biofilm formation in Vibrio fischeri symbionts
Zarate, D.; Isenberg, R. Y.; Pavelsky, M.; Speare, L.; Jackson, A.; Mandel, M. J.; Septer, A. N.
10.1101/2024.12.19.629378 — microbiology — Posted on 2024-12-20
1743 Longitudinal prevalence and co-carriage of pathogens associated with nursing home acquired pneumonia in three long-term care facilities
Whealy, R. N.; Roberts, A.; Furstenau, T. N.; Timm, S.; Maltinsky, S.; Wells, S.; Drake, K.; Ramirez, K.; Bolduc, C.; Ross, A.; Pearson, T.; Fofanov, V. Y.
10.1101/2024.12.19.629505 — microbiology — Posted on 2024-12-20
1745 Study of the immunogenicity, efficacy and safety of recombinant RBD SARS-CoV-2 vaccine with CpG adjuvant in rodent, non-rodent and Maccaca fascicularis using Indonesian Strain Virus
Limeilati, N. A.; Nidom, R. V.; Sari, T. T.; Kusumarahayu, N. P.; Fransiska, S. V.; Indrasari, S.; Garmana, A. N.; Ayuningtyas, D. K.; Nugroho, G. S.; Darsono, ; Maharani, ; Wijayadikusumah, A. R.; Sukandar, E. Y.; Nidom, A. N.; Adnyana, I. K.; Nurainy, N.; Nidom, C.
10.1101/2024.12.18.629000 — immunology — Posted on 2024-12-20
1746 FABP5 in Skin Macrophages Mediates Saturated Fat-Induced IL-1β Signaling in Obesity-Associated Psoriasis Development
Yu, J.; Hao, J.; Yorek, M. S.; Jiang, X.; Avellino, A.; Liu, S.; Han, X.; Shilyansky, J.; Wang, Z.; Jabbari, A.; Li, B.
10.1101/2024.12.16.628705 — immunology — Posted on 2024-12-20
1747 LPS stimulates dynamic changes in B cell metabolism to promote proliferation
Cheung, D. M. S.; Razsolkov, M.; Bonacina, F.; Andrews, S.; Sumoreeah, M.; Sinclair, L. V.; Howden, A. J. M.; Arthur, J. S. C.
10.1101/2024.12.16.628649 — immunology — Posted on 2024-12-20
1748 Comprehensive Analysis of Human Dendritic Spine Morphology and Density: Exploring Diversity of Human Dendritic Spines
Schuenemann, K. D.; Hattingh, R. M.; Verhoog, M. B.; Yang, D.; Bak, A.; Peter, S.; van Loo, K. M. J.; Wolking, S.; Kronenberg-Versteeg, D.; Weber, Y.; Schwarz, N.; Raimondo, J. V.; Melvill, R.; Tromp, S.; Butler, J.; Hoellig, A.; Delev, D.; Wuttke, T. V.; Kampa, B. M.; Koch, H.
10.1101/2024.12.18.629169 — neuroscience — Posted on 2024-12-20
1749 Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability
Garcia, J. D.; Wang, C.; Banks, E.; Fenton, T.; DeKeyser, J.-M.; Abramova, T. V.; George, A. L.; Ben-Shalom, R.; Hackos, D. H.; Bender, K. J.
10.1101/2024.12.17.629038 — neuroscience — Posted on 2024-12-20
1750 Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior
Mattioni, L.; Poggi, G.; Gallagher, C.; Becker, K.; Papic, M.; Herzog, D. P.; Nardi, L.; Conrad, A.; Wintenberg, S.; Lutz, B.; Waismann, A.; Mittmann, T.; Schmeisser, M. J.; Mueller, M. B.; Treccani, G.
10.1101/2024.12.20.629639 — neuroscience — Posted on 2024-12-20
1752 Voice identity invariance by anterior temporal lobe neurons
Giamundo, M.; Trapeau, R.; Thoret, E.; Renaud, L.; Brochier, T.; BELIN, P.
10.1101/2024.12.19.629267 — neuroscience — Posted on 2024-12-20
1754 The active subset of grassland soil microbiomes changes with soil depth, water availability and prominently features predatory bacteria and episymbionts
Penev, P. I.; Estera-Molina, K.; Allen, G. M.; Sachdeva, R.; Lei, S.; Law, K. K.; Hoff, J.; Blazewicz, S. J.; Pett-Ridge, J.; Banfield, J. F.
10.1101/2024.12.19.629468 — bioinformatics — Posted on 2024-12-20
1755 Linkage-based ortholog refinement in bacterial pangenomes with CLARC
Ojeda, I. G.; Palace, S. G.; Martinez, P. P.; Azarian, T.; Grant, L. R.; Hammitt, L.; Hanage, B.; Lipsitch, M.
10.1101/2024.12.18.629228 — bioinformatics — Posted on 2024-12-20
1757 Genetically Encoded Red Fluorescent Indicators for Imaging Intracellular and Extracellular Potassium Ions
Yang, L.; Pathiranage, V.; Zhou, S.; Sun, X.; Zhang, H.; Lai, C.; Gu, C.; Subach, F. V.; Walker, A. R.; Piatkevich, K. D.
10.1101/2024.12.20.629597 — biochemistry — Posted on 2024-12-20
1758 Bottom-up design of calcium channels from defined selectivity filter geometry
Liu, Y.; Weidle, C.; Mihaljevic, L.; Watson, J. L.; Li, Z.; Yu, L. T.; Majumder, S.; Borst, A. J.; Carr, K. D.; Kibler, R. D.; Gamal El-Din, T. M.; Catterall, W. A.; Baker, D.
10.1101/2024.12.19.629320 — biochemistry — Posted on 2024-12-20
1759 Tiled Amplicon Sequencing Enables Culture-free Whole-Genome Sequencing of Pathogenic Bacteria From Clinical Specimens
Kalinich, C. C.; Gonzalez, F. L.; Omaston, A.; Breban, M. I.; Distefano, I.; Leon, C.; Sheen, P.; Zimic, M.; Coronel, J.; Tan, G.; Crudu, V.; Ciobanu, N.; Codreanu, A.; Solano, W.; Raez, J.; Allicock, O. M.; Chaguza, C.; Wyllie, A. L.; Brandt, M.; Weinberger, D. M.; Sobkowiak, B.; Cohen, T.; Grandjean, L.; Grubaugh, N. D.; Redmond, S. N.
10.1101/2024.12.19.629550 — genomics — Posted on 2024-12-20
1760 Integrated analysis of COVID-19 multi-omics data for eQTLs reveals genetic mechanisms underlying disease severity
Lee, J.; Jeon, E. Y.; Yu, L.; Jo, H.-Y.; Kim, S. C.; Park, W.-Y.; Park, H.-Y.; Zhao, S.; Choi, M.
10.1101/2024.12.18.629144 — genetics — Posted on 2024-12-20
1761 Global patterns of genetic admixture reveal effects of language contact
Graff, A.; Blasi, D. E.; Ringen, E. J.; Bajic, V.; Bavelier, D.; Shimizu, K. K.; Pakendorf, B.; Barbieri, C.; Bickel, B.
10.1101/2024.12.19.629340 — evolutionary biology — Posted on 2024-12-20
1762 An inverse correlation between linguistic and genetic diversity
Graff, A.; Ringen, E. J.; Zakharko, T.; Stoneking, M.; Shimizu, K. K.; Bickel, B.; Barbieri, C.
10.1101/2024.12.18.628602 — evolutionary biology — Posted on 2024-12-20
1763 Integration of spatial and single nucleus transcriptomics to map gene expression in the developing mouse kidney
Chaney, C.; Fusco, A. N.; Grilli, E. D.; Warshaw, J. N.; Luo, P. M.; Cleaver, O.; Marciano, D. K.; Carroll, T. J.
10.1101/2024.12.18.629207 — developmental biology — Posted on 2024-12-20
1766 Base-modified nucleotides mediate immune signaling in bacteria
Zeng, Z.; Hu, Z.; Zhao, R.; Rao, J.; Mestre, M.; Liu, Y.; Liu, S.; Feng, H.; Chen, Y.; He, H.; Chen, N.; Zheng, J.; Peng, D.; Luo, M.; She, Q.; Pinilla-Redondo, R.; Han, W.
10.1101/2024.12.20.629578 — microbiology — Posted on 2024-12-20
1768 Recombinant Pichinde reporter virus as a safe and suitable surrogate for high-throughput antiviral screening against highly pathogenic arenaviruses
Sacramento, C. Q.; Bott, R.; Huang, Q.; Eaton, B.; Postnikova, E.; Sabir, A. J.; Argade, M. D.; Ratia, K.; Anantpadma, M.; Carlier, P. R.; Ly, H.; Liang, Y.; Rong, L.
10.1101/2024.12.19.629433 — microbiology — Posted on 2024-12-20
1769 Structural Insights into the Assembly and Regulation of 2'-O RNA Methylation by SARS-CoV-2 nsp16/nsp10
Misra, A.; Rahisuddin, R.; Parihar, M.; Arya, S.; Viswanathan, T.; Jackson, N.; Qi, S.; Chan, S.-H.; Harris, R. S.; Martinez-Sobrido, L.; Gupta, Y.
10.1101/2024.12.19.628950 — microbiology — Posted on 2024-12-20
1771 Role of the clathrin adaptor AP-1 in cell wall integrity and virulence factor secretion in the plant pathogen Botrytis cinerea
Calvar, G.; Hamandjian, A.; Crumiere, M.; Dupuy, J.-W.; Moriscot, C.; Gallet, B.; de Vallee, A.; Rascle, C.; Choquer, M.; Bruel, C.; Poussereau, N.
10.1101/2024.12.19.629338 — microbiology — Posted on 2024-12-20
1773 Infectious potential and circulation of SARS-CoV-2 in wild rats
Beissat, K.; Lattard, V.; Picard-Meyer, E.; Fafournoux, A.; Soro, S. D.; Servat, A.; Vincent-Hubert, F.; Boue, F.; Chatron, N.; Monchatre-Leroy, E.; Wasniewski, M.
10.1101/2024.12.19.629569 — microbiology — Posted on 2024-12-20
1776 Single Cell RNAseq to identify subpopulations of glial progenitors in iPSC-derived oligodendroglial lineage cultures
Blaszczyk, G. J.; Piscopo, V. E. C.; Goldsmith, T. M.; Chapleau, A.; Sirois, J.; Bernard, G.; Antel, J.; Durcan, T. M.
10.1101/2024.12.18.629204 — neuroscience — Posted on 2024-12-20
1778 Segregated localization of target-SNARE proteins within presynaptic terminals of Munc18-1 deficient photoreceptors
Huang, M.; Chow, C. H.; Charish, J.; Indrawinata, K.; Harada, H.; Wallace, V. A.; Monnier, P. P.; Sugita, S.
10.1101/2024.12.19.629437 — neuroscience — Posted on 2024-12-20
1780 Statins inhibit onco-dimerization of the 4Ig isoform of B7-H3
Sutton, M. N.; Glazer, S. E.; Al Zaki, A.; Napoli, A.; Yang, P.; Bhosale, P.; Liu, J.; Gammon, S. T.; Piwnica-Worms, D.
10.1101/2024.12.18.628944 — cancer biology — Posted on 2024-12-20
1782 Prediction of Cell States and Key Transcription Factors of the Human Cornea through Integrated Single-Cell Omics Analyses
Arts, J. A.; Fallo, S.; Florencio, M. S.; Smits, J. G. A.; Lima Cunha, D.; Roubroeks, J. A. Y.; Dickman, M. M. M.; LaPointe, V. L. S.; Yu, R.; Zhou, H.
10.1101/2024.12.19.629354 — cell biology — Posted on 2024-12-20
1783 IVISc-L: A quick and simple in vivo assay to study the regulation of gene expression
Som, S.; Vishalakshi, G. J.; Manjunath, L. E.; Manna, D.; Vasu, K.; Singh, A.; Eswarappa, S.
10.1101/2024.12.16.628807 — molecular biology — Posted on 2024-12-20
1784 The clumped isotope signatures of multiple methanogenesis metabolisms
Li, J.; Ash, J. L.; Cobban, A.; Kubik, B. C.; Rizzo, G.; Thompson, M.; Guibourdenche, L.; Berger, S.; Morra, K.; Lin, Y.; Mueller, E. P.; Masterson, A. L.; Stein, R.; Fogel, M.; Torres, M. A.; Feng, X.; Holden, J. F.; Martini, A.; Welte, C.; Jetten, M. S. M.; Young, E. D.; Leavitt, W. D.
10.1101/2024.12.18.629299 — microbiology — Posted on 2024-12-20
1786 Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures
Li, H.; Pham, M. C.; Teng, J.; O'Connor, K. C.; Noviello, C. M.; Hibbs, R. E.
10.1101/2024.12.18.629229 — neuroscience — Posted on 2024-12-20
1787 Deciphering single-cell heterogeneity and cellular ecosystem dynamics during prostate cancer progression
Zhao, F.; Zeng, J.; Chen, C.; Zhao, X.; Zhang, T.; Thomas, G. V.; Sears, R. C.; Alumkal, J. J.; Moran, A. E.; Mills, G. B.; Nelson, P. S.; Xia, Z.
10.1101/2024.12.18.629070 — cancer biology — Posted on 2024-12-20
1788 Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production.
Kacem, H.; Kunz, L.; Korysko, P.; Ollivier, J.; Tsoutsou, P.; Martinotti, A.; Rieker, V.; Bateman, J.; Farabolini, W.; Baldacchino, G.; Loo, B. W.; Limoli, C. W.; Dosanjh, M.; Corsini, R.; Vozenin, M.-C.
10.1101/2024.12.19.629203 — cancer biology — Posted on 2024-12-20
1789 Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma
Vardon, A.; Haston, S.; Guiho, R.; Carvahlo, D.; Carter, R.; Boult, J.; Gharai, D.; Santhakumar, D.; Cloete, I.; Gray, J.; Apps, J.; Ogunbiyi, O.; Zhou, D.; Zheng, G.; Martinez-Manez, R.; Lythgoe, M. L.; Donovan, L.; Montero Carcaboso, A.; Williams, O.; Gil, J.; Jacques, T.; Dean, J.; Michod, D.; Jones, C.; Hargrave, D.; Martinez-Barbera, J.-P.
10.1101/2024.12.20.629607 — cancer biology — Posted on 2024-12-20
1790 Trastuzumab deruxtecan combination strongly enhances responses and overcomes sotorasib resistance in KRASG12C-mutant NSCLC
Ozakinci, H.; Desai, B.; Kalos, D.; Chen, D.-T.; Henry, M.; Solanki, H.; Boyle, T.; Trejo-Bittar, H.; Nazario, G. S.; Haura, E.; Marusyk, A.; Pellini, B.
10.1101/2024.12.17.628751 — cancer biology — Posted on 2024-12-20
1791 CD38 biallelic loss is a recurrent mechanism of resistance to anti-CD38 antibodies in multiple myeloma.
Diamond, B.; Baughn, L.; Poorebrahim, M.; Poos, A. M.; Lee, H.; Kaddoura, M.; Wiedmeier-Nutor, E.; Durante, M.; Otteson, G.; Jevremovic, D.; Tang, H.; Frohling, S.; Baertsch, M. A.; Papadimitriou, M.; Ziccheddu, B.; Jelinek, T.; Lemoine, C.; Rak, A.; Green, D. J.; Landgren, O.; Neri, P.; Bergsagel, L.; Braggio, E.; Kumar, S.; Raab, M. S.; Fonseca, R.; Bahlis, N.; Weinhold, N.; MAURA, F.
10.1101/2024.12.17.628799 — cancer biology — Posted on 2024-12-20
1792 Covalent inhibitors of the RAS binding domain of PI3Ka impair tumor growth driven by RAS and HER2
Klebba, J. E.; Roy, N.; Bernard, S. M.; Grabow, S.; Hoffman, M. A.; Miao, H.; Tamiya, J.; Wang, J.; Berry, C.; Esparza-Oros, A.; Lin, R.; Liu, Y.; Pariollaud, M.; Parker, H.; Mochalkin, I.; Rana, S.; Snead, A. N.; Walton, E. J.; Wyrick, T. E.; Aitichson, E.; Bedke, K.; Brannon, J. C.; Chick, J. M.; Hee, K.; Horning, B. D.; Ismail, M.; Lamb, K. N.; Lin, W.; Metzger, J.; Pastuszka, M. K.; Pollock, J.; Sigler, J. J.; Tomaschko, M.; Tran, E.; Kinsella, T. M.; Molina-Arcas, M.; Simon, G. M.; Weinstein, D. S.; Downward, J.; Patricelli, M. P.
10.1101/2024.12.17.629001 — cancer biology — Posted on 2024-12-20
1794 Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease
Morsy, Y.; Walberg, A.; Wawrzyniak, P.; Hubeli, B.; Truscello, L.; Mamie, C.; Niechcial, A.; Gueguen, E.; Manzini, R.; Gottier, C.; Lang, S.; Sylvie, S.; Bluemel, S.; Biedermann, L.; Rogler, G.; Turina, M.; Ramser, M.; Petrowsky, H.; Arnold, I.; Zeissig, S.; Zamboni, N.; Egli, A.; Niess, J.; Hruz, P.; Knuth, A.; Fritsch, R.; Manz, M.; Wawrzyniak, M.; Scharl, M.
10.1101/2024.12.16.628609 — cancer biology — Posted on 2024-12-20
1795 De novo design of proteins that bind naphthalenediimides, powerful photooxidants with tunable photophysical properties
Mann, S. I.; Lin, Z.; Tan, S. K.; Zhu, J.; Widel, Z. X.; Bakanas, I.; Mansergh, J. P.; Liu, R.; Kelly, M. J.; Wu, Y.; Wells, J. A.; Therien, M. J.; DeGrado, W. A.
10.1101/2024.09.30.615927 — biophysics — Posted on 2024-12-20
1796 Conformational dynamics of a histidine molecular switch in a cation/proton antiporter
Pecorilla, C.; Altmeyer, A.; Haapanen, O.; Lee, Y.; Zickermann, V.; Sharma, V.
10.1101/2024.12.20.629634 — biophysics — Posted on 2024-12-20
1797 MorphoDiff: Cellular Morphology Painting with Diffusion Models
Navidi, Z.; Ma, J.; Miglietta, E. A.; Liu, L.; Carpenter, A. E.; Cimini, B. A.; Haibe-Kains, B.; Wang, B.
10.1101/2024.12.19.629451 — bioinformatics — Posted on 2024-12-20
1799 Accurate and fast segmentation of filaments and membranes in micrographs and tomograms with TARDIS
Kiewisz, R.; Fabig, G.; Conway, W.; Johnston, J.; Kostyuchenko, V.; Barinka, C.; Clarke, O. B.; Magaj, M.; Yazdkhasti, H.; Vallese, F.; Lok, S.-m.; Redemann, S.; Muller-Reichert, T.; Bepler, T.
10.1101/2024.12.19.629196 — bioinformatics — Posted on 2024-12-20
1801 The Neuropeptide Sulfakinin, a peripheral regulator of insect behavior switch between mating and foraging
Li, H.-F.; Dong, B.; Peng, Y.-Y.; Luo, H.-Y.; Ou, X.-L.; Ren, Z.-L.; Park, Y.; Wang, J.-J.; Jiang, H.
10.1101/2024.07.30.605941 — ecology — Posted on 2024-12-20
1803 Coordinated repression of totipotency-associated gene loci by histone methyltransferase EHMT2 through binding to LINE-1 regulatory elements
Chatterjee, K.; Uyehara, C. M.; Kasliwal, K.; Madhuranath, S.; Scourzic, L.; Polyzos, A.; Apostolou, E.; Stadtfeld, M.
10.1101/2024.12.18.629181 — developmental biology — Posted on 2024-12-20
1805 Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis
Semler, E. M.; Michell, D. L.; Kingsley, P. J.; Massick, C.; Ramirez, M. A.; Castleberry, M. A.; Doran, A. C.; Carr, J. J.; Marnett, L. J.; Sheng, Q.; Linton, M. F.; Vickers, K. C.
10.1101/2024.12.19.628772 — cell biology — Posted on 2024-12-20
1808 Impact of wildfire smoke and diesel exhaust on inflammatory response in aging human microglia
Cuni-Lopez, C.; Ng, M. F.; Stewart, R.; Milton, L. A.; Etebar, F.; Sun, Y.; Vivian, E.; Nguyen, T.; Asare, P. F.; Lupton, M. K.; Roberts, T. L.; Ristovski, Z.; Hodge, S.; Reynolds, P. N.; White, A. R.; Quek, H.
10.1101/2024.12.20.629570 — cell biology — Posted on 2024-12-20
1809 Inhibition of the metalloprotease ADAM19 as a Novel Senomorphic Strategy to Ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP)
Bar, S.; Hilsabeck, T. A. U.; Pattavina, B.; Dominguez, J. A. L.; Basisty, N.; Bons, J.; Watson, M.; Schilling, B.; Campisi, J.; Kapahi, P.; Sharma, A.
10.1101/2024.12.16.628718 — molecular biology — Posted on 2024-12-20
1810 C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain
Crowley, G.; Turkes, E.; Kim, M.; De Schepper, S.; Tan, B. J. Y.; Rueda-Carrasco, J.; Toneva, M.; Fajardo, J. C.; Ge, J. Z.; Yang, Z. G.; Paoletti, C.; Sow, T.; Posner, D. A.; Sierksma, A.; Ferreira, L. S. S.; Sokolova, D.; Konstantellos, V.; MacAskill, A. F.; Clatworthy, M. R.; Hong, S.
10.1101/2024.12.18.629085 — neuroscience — Posted on 2024-12-20
1811 Host and rabies virus gene expression is shaped by human brain cell type and reveals a preexisting pro-viral transcriptional state in astrocytes
Feige, L.; Young, K.; Cerapio, J. P.; Kozaki, T.; Kergoat, L.; Libri, V.; Ginhoux, F.; Hasan, M.; Ben Ameur, L.; Chin, G.; Goode, Z.; Bourhy, H.; Saunders, A.
10.1101/2024.12.18.629263 — neuroscience — Posted on 2024-12-20
1813 Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice
Antonucci, S.; Caron, G.; Dikwella, N.; Krishnamurthy, S. S.; Harster, A.; Zarrin, H.; Tahanis, A.; Olde Heuvel, F.; Danner, S. M.; Ludolph, A. C.; Grycz, K.; Baczyk, M.; Zytnicki, D.; Roselli, F.
10.1101/2024.03.25.586570 — neuroscience — Posted on 2024-12-20
1814 Social touch shapes communication and animal recognition in naked mole-rats
Schwark, R.; Ogundare, S.; Weinreb, C.; Sheng, P.; Foster, W.; Toussaint, A.; Chang, P.; Tsai, Y.-Y.; Comfere, M.; Arnold, A.; Guadagnino, A.; McCloskey, D.; Schaffer, E.; Rajan, K.; Datta, S. R.; Abdus-Saboor, I.
10.1101/2024.02.21.581483 — neuroscience — Posted on 2024-12-20
1815 Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression
Coley, A.; Batra, K.; Delahanty, J.; Keyes, L.; Pamintuan, R.; Ramot, A.; Hagemann, J.; Lee, C.; Liu, V.; Adivikolanu, H.; Cressy, J.; Jia, C.; Massa, F.; LeDuke, D.; Gabir, M.; Durubeh, B.; linderhof, L.; Patel, R.; Wichmann, R.; Li, H.; Fischer, K.; Pereira, T.; Tye, K.
10.1101/2024.12.18.629202 — neuroscience — Posted on 2024-12-20
1817 Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen and Identifies Co-Treatment Strategies in Estrogen Receptor Positive Breast Cancer
Kakati, R. T.; Whitman, A. A.; Haase, S.; Szenasi, A. T.; Thai, C. H.; Brunk, E. C.; Okumu, D. O.; East, M. P.; Perou, C. M.; Johnson, G. L.; Spanheimer, P. M.
10.1101/2024.12.19.629395 — cancer biology — Posted on 2024-12-20
1818 BRAF V600 and ErbB inhibitors directly activate GCN2 in an off-target manner to limit cancer cell proliferation
Ill, C. R.; Marikar, N. C.; Nguyen, V.; Nangia, V.; Darnell, A. M.; Vander Heiden, M. G.; Reigan, P.; Spencer, S. L.
10.1101/2024.12.19.629301 — cancer biology — Posted on 2024-12-20
1819 Gene expression adaptation of metastases to their host tissue
Nagel, L.; Wenzel, M.; Hoppe, S.; Plum, P. S.; Karimpour, M.; Franitza, M.; Wahba, R.; Bludau, M.; Bruns, C. J.; Quaas, A.; Beyer, A.; Hillmer, A.
10.1101/2024.12.18.629130 — cancer biology — Posted on 2024-12-20
1820 WNT7B drives a program for pancreatic cancer subtype switching and progression
Sprangers, J.; Bugter, J. M.; Xanthakis, D.; Boekhout, M.; Kok, R. N. U.; Brosens, L. A. A.; Dijk, F.; Rodriguez Colman, M. J.; van der Vaart, J. Y.; Maurice, M. M.
10.1101/2024.12.18.628910 — cancer biology — Posted on 2024-12-20
1823 Targeting de novo lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma
Hancock, S. E.; Garthwaite, L.; Harellis, K.; Susetio, M.; Ding, E.; Choong, L.; Contreras, O.; Nguyen, A.; Lising, J.; Hansen, F. K.; Wongsomboon, P.; Menzel, J. P.; Poad, B. L.; Mitchell, T. W.; Blanksby, S. J.; Turner, N.
10.1101/2024.12.18.628624 — cancer biology — Posted on 2024-12-20
1824 GlioME: A Novel Organoid Model Retaining the Glioma Mi-croenvironment for Personalized Drug Screening and Thera-peutic Evaluation
Zheng, C.; Chen, Q.; Wang, P.; Zhang, D.; Fang, Z.; Feng, Y.; Chen, J.; Chen, J.; Fu, Y.; Yang, B.; Zhao, Q.; Sun, F.; Zhang, Y.; Jiang, T.; Zheng, L.; Bao, Z.
10.1101/2024.12.17.628908 — cancer biology — Posted on 2024-12-20
1827 A fully 3D-printed optical microscope for low-cost histological imaging
Christopher, J.; Craig, R.; McHugh, R. E.; Roe, A. J.; Bauer, R.; Patton, B.; McConnell, G.; Rooney, L. M.
10.1101/2024.12.16.628684 — biophysics — Posted on 2024-12-20
1830 Phylogenomic prediction of interaction networks in the presence of gene duplication
Forsythe, E. S.; Gatts, T. C.; Lane, L. E.; deRoux, C.; Berggren, M.; Rehmann, E. A.; Zak, E.; Bartel, T.; L'Argent, L.; Sloan, D. B.
10.1101/2024.08.06.606904 — genomics — Posted on 2024-12-20
1832 The TRX assay for triplet repeat expansions
O'Brien, T.; Salciute, K.; Kieffer, S.; Ponraj, N. K. P.; Richer, M.; Marzec, P.; Benn, C.; Monckton, D. G.; Dion, V.; Lahue, R.
10.1101/2024.12.18.629104 — genetics — Posted on 2024-12-20
1834 Deciphering Coral Reef Soundscapes Utilizing 360 Video and Spatial Audio
Dantzker, M. S.; Duggan, M. T.; Berlik, E.; Delikaris-Manias, S.; Bountourakis, V.; Pulkki, V.; Rice, A. N.
10.1101/2024.12.16.628659 — ecology — Posted on 2024-12-20
1836 NUAK1 regulates contraction in vascular smooth muscle cells derived from abdominal aortic aneurysm patients
Rombouts, K. B.; van Merrienboer, T. A. R.; Henneman, A. A.; Knol, J. C.; Pham, T. V.; Piersma, S. R.; Jimenez, C. R.; Hordijk, P. L.; Bogunovic, N.; van der Velden, J.; Yeung, K. K.
10.1101/2024.12.19.629332 — cell biology — Posted on 2024-12-20
1837 Nuclear metabolism oscillation during the cell cycle reveals a link between the phosphatidylinositol pathway and histone methylation.
Ganez-Zapater, A.; Kourtis, S.; Espinar, L.; Garcia-Lopez, L.; Wiegand, L.; Guirola, M.; Fontaine, F.; Müller, A. C.; Sdelci, S.
10.1101/2024.12.20.629614 — cell biology — Posted on 2024-12-20
1840 Investigating the Impacts of Sphingomyelinases on Extracellular Vesicle Cargo Sorting
Padilla, J.-C. A.; Barutcu, S.; Boulais, J.; Chen, Y.; Syed, E.; Kwon, E.; Lecuyer, E.
10.1101/2024.12.16.628770 — molecular biology — Posted on 2024-12-20
1841 Viro3D: a comprehensive database of virus protein structure predictions
Litvin, U.; Lytras, S.; Jack, A.; Robertson, D. L.; Grove, J.; Hughes, J.
10.1101/2024.12.19.629443 — microbiology — Posted on 2024-12-20
1842 Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent
Lejeune, A.; Zhou, C.; Ercelen, D.; Putzel, G.; Yao, X.; Guy, A. R.; Pawline, M.; Podkowik, M.; Pironti, A.; Torres, V. J.; Shopsin, B.; Cadwell, K.
10.1101/2024.07.17.603994 — immunology — Posted on 2024-12-20
1843 Identification of Druggable Binding Sites and Small Molecules as Modulators of TMC1
De-la-Torre, P.; Martinez-Garcia, C.; Gratias, P.; Mun, M.; Santana, P.; Akyuz, N.; Gonzalez, W.; Indzhykulian, A. A.; Ramirez, D.
10.1101/2024.03.05.583611 — neuroscience — Posted on 2024-12-20
1844 Dynamics of pitch perception in the auditory cortex
Abrams, E. B.; Marantz, A.; Krementsov, I.; Gwilliams, L.
10.1101/2024.06.10.598008 — neuroscience — Posted on 2024-12-20
1846 The Aging Synapse: An Integrated Proteomic And Transcriptomic Analysis
Caterino, C.; Ugolini, M.; Durso, W.; Jevdokimenko, K.; Groth, M.; Riege, K.; Goerlach, M.; Fornasiero, E.; Ori, A.; Hoffmann, S.; Cellerino, A.
10.1101/2024.12.18.629115 — neuroscience — Posted on 2024-12-20
1849 The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in severe models of COVID-19.
Penrice-Randal, R.; Bentley, E. G.; Sharma, P.; Kirby, A.; Donovan-Banfield, I.; Kipar, A.; Mega, D. F.; Bramwell, C.; Sharp, J.; Owen, A.; Hiscox, J. A.; Stewart, J. P.
10.1101/2024.02.27.582110 — pharmacology and toxicology — Posted on 2024-12-20
1850 A histomorphological atlas of resected mesothelioma discovered by self-supervised learning from 3446 whole-slide images
Seyedshahi, F.; Rakovic, K.; Poulain, N.; Quiros, A. C.; Powley, I. R.; Klebe, S.; Richards, C.; Uraiby, H.; Nakas, A.; Wilson, C.; Sereno, M.; Officer-Jones, L.; Ficken, C.; Teodosio, A.; Ballantyne, F.; Murphy, D.; Yuan, K.; Le Quesne, J.
10.1101/2024.11.18.624103 — pathology — Posted on 2024-12-20
1851 Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma
Yang, J.; Lim, J. T.; Santiago Raj, P. V.; Corona, M. G.; Chen, C.; Khawaja, H.; Pan, Q.; Paine-Murrieta, G. D.; Schnellmann, R. G.; Roe, D. J.; Gokhale, P. C.; DeCaprio, J. A.; Padi, M.
10.1101/2023.11.01.565218 — cancer biology — Posted on 2024-12-20
1853 Actin dysregulation induces immune evasion via oxidative stress-activated PD-L1 in gastric cancer
Seo, Y.; Jang, J.; Ko, K.-P.; Zou, G.; Huang, Y.; Zhang, S.; Zhang, J.; Jun, S.; Chu, W.; Venkatesan, V.; Dhakshinamoorthy, S.; Park, J.-I.
10.1101/2024.12.18.629227 — cancer biology — Posted on 2024-12-20
1855 CSF1R-CAR T cells induce CSF1R signalling and promote cancer cell growth
Callahan, A.; Zhang, X.; Wang, A.; Mojumdar, A.; Zeng, L.; Su, X.; Salomon, A. R.
10.1101/2024.12.17.629028 — cancer biology — Posted on 2024-12-20
1857 Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells
Wu, G.-H.; Hou, C.; Thron, A.; Patel, H. R.; Spillane, L.; Gupte, S. R.; Yeung-Levy, S.; Gulati, S.; Booth, C.; Liao, Y. J.; Chiu, W.
10.1101/2024.12.17.628994 — biophysics — Posted on 2024-12-20
1858 Flow-Induced Vascular Remodeling On-Chip: Implications for Anti-VEGF Therapy
Mirzapour-Shafiyi, F.; Huber, E.; Karr, L.; Tong, J.; Bausch, A. R.; Simmel, F. C.; Alim, K.
10.1101/2024.11.29.625475 — biophysics — Posted on 2024-12-20
1860 Differential substrate specificity of ERK, JNK, and p38 MAP kinases toward Connexin 43
Latchford, L. P.; Perez, L. S.; Conage-Pough, J. E.; Turk, R.; Cusimano, M. A.; Vargas, V. I.; Arora, S.; Shienvold, S. R.; Kulp, R. R.; Belverio, H. M.; White, F. M.; Thevenin, A. F.
10.1101/2023.12.30.573692 — biochemistry — Posted on 2024-12-20
1861 Back to the horns: a reconstruction of the ancestral horn state through distinct types of recombination events.
Upadhyay, M.; Graf, A.; pogorevc, N.; Seichter, D.; Russ, I.; Krebs, S.; Meier, S.; Medugorac, I.
10.1101/2024.11.18.624115 — genomics — Posted on 2024-12-20
1865 Quantitative Genetics of Microbiome Mediated Traits
Week, B.; Ralph, P. L.; Tavalire, H. F.; Cresko, W. A.; Bohannan, B. J. M.
10.1101/2024.12.16.628599 — evolutionary biology — Posted on 2024-12-20
1867 A Spatiotemporal Atlas of Mouse Gastrulation and Early Organogenesis to Explore Axial Patterning and Project In Vitro Models onto In Vivo Space
Harland, L. T.; Lohoff, T.; Koulena, N.; Pierson, N.; Pape, C.; Ameen, F.; Griffiths, J.; Theeuwes, B.; Wilson, N. K.; Kreshuk, A.; Reik, W.; Nichols, J.; Cai, L.; Marioni, J. C.; Gottgens, B.; Ghazanfar, S.
10.1101/2024.12.12.628063 — developmental biology — Posted on 2024-12-19
1868 Morphogenetic constrains in the development of gastruloids: implications for mouse gastrulation
Fiuza, U.-M.; Bonavia, S.; Pascual-Mas, P.; Torregrosa-Cortes, G.; Casani-Galdon, P.; Robertson, G.; Dias, A.; Martinez Arias, A.
10.1101/2024.12.12.628151 — developmental biology — Posted on 2024-12-20
1872 Pulmonary fibroblast activation during Aspergillus fumigatus infection enhances lung defense via immunomodulation and tissue remodeling
Guirao-Abad, J. P.; Shearer, S. M.; Bowden, J.; Kasprovic, D. A.; Grisham, C.; Ozdemir, M.; Tranter, M.; Wang, Y.; Askew, D. S.; Kanisicak, O.
10.1101/2024.12.19.629499 — cell biology — Posted on 2024-12-20
1874 The inhibitory effects of Remodelin on murine myoblasts differentiation
Sian, V.; Hentschel, A.; Sarparanta, J.; Roos, A.; Jonson, P. H.; Natraj Gayathri, S.; Mai, A.; Rotili, D.; Altucci, L.; Udd, B.; Savarese, M.; Nebbioso, A.
10.1101/2024.12.19.629326 — cell biology — Posted on 2024-12-20
1875 A FUCCI sensor reveals complex cell cycle organization of Toxoplasma endodyogeny
Batra, M.; Marsilia, C.; Awshah, D.; Hawkins, L. M.; Wang, C.; Chaput, D.; Naumova, D. A.; Suvorova, E. S.
10.1101/2024.09.02.610821 — cell biology — Posted on 2024-12-20
1876 Spatial Perturb-Seq: Single-Cell Functional Genomics within Intact Tissue Architecture
Shen, K.; Seow, W. Y.; Keng, C. T.; Lim, D.; Guo, K.; Meliani, A.; Muhammad Bin Hajis, I.; Chen, K. H.; Chew, W. L.
10.1101/2024.12.19.628843 — cell biology — Posted on 2024-12-20
1877 The Chromosome Periphery is an Essential Compartment of Oocyte Chromosomes
Simpson, E. L.; Wetherall, B.; Cheeseman, L. P.; Byrska, A.; Mendonca, T.; Xing, X.; Beckett, A. J.; Maiato, H.; Sarginson, A.; Prior, I. A.; Hartshorne, G. M.; McAinsh, A.; Madgwick, S.; Booth, D. G.
10.1101/2024.12.20.629576 — cell biology — Posted on 2024-12-20
1879 Vascular endothelial growth factor-D improves lung vascular integrity during acute lung injury
Yuan, Y.; Sharma, L.; Tang, W.; Yoon, Y.; kirk, S.; Raredon, M. S. B.; Ahangari, F.; Khoury, J.; Qian, H.; Luan, Y.; Yuan, Q.; Chen, L.; Ke, Y.; Birukov, K.; Simons, M.; Wu, D.; Niklason, L. E.; Kaminski, N.
10.1101/2024.12.16.628787 — molecular biology — Posted on 2024-12-20
1880 Cervicovaginal microbial features predict Chlamydia trachomatis spread to the upper genital tract of infected women
Jeong, S.; Tollison, T. S.; Brochu, H.; Huntress, I.; Yount, K. S.; Zheng, X.; Darville, T.; O'Connell, C. M.; Peng, X.
10.1101/2024.11.26.625070 — microbiology — Posted on 2024-12-20
1882 Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein
Waki, K.; Tani, H.; Kawahara, E.; Saga, Y.; Shimada, T.; Yamazaki, E.; Koike, S.; Morinaga, Y.; Isobe, M.; Kurosawa, N.
10.1101/2023.04.10.536311 — immunology — Posted on 2024-12-20
1883 cfos principal cells and interneurons are strongly reactivated by sharp wave ripples
Javed, M. H.; Robles-Hernandez, E. M.; Patel, R.; Haberl, M. G.; da Silva, S. V.
10.1101/2024.12.17.628897 — neuroscience — Posted on 2024-12-20
1884 Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility
Gomez-Frittelli, J.; Devienne, G. F.; Travis, L.; Kyloh, M. A.; Duan, X.; Hibberd, T. J.; Spencer, N. J.; Huguenard, J. R.; Kaltschmidt, J.
10.1101/2024.08.06.606748 — neuroscience — Posted on 2024-12-20
1885 Spatial and network principles behind neural generation of locomotion
Komi, S.; Winther, A.; Houser, G.; Topilko, T.; Sorensen, R. J.; Larsen, S.; Bonfils, M.; Li, G.; Berg, R. W.
10.1101/2024.10.03.616472 — neuroscience — Posted on 2024-12-20
1887 Sequence action representations contextualize during rapid skill learning
Dash, D.; Iwane, F.; Hayward, W.; Salamanca-Giron, R.; Bonstrup, M.; Buch, E.; Cohen, L.
10.1101/2024.08.15.608189 — neuroscience — Posted on 2024-12-20
1890 Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines
Meany, E. L.; Klich, J. H.; Jons, C. K.; Mao, T.; Chaudhary, N.; Utz, A.; Baillet, J.; Song, Y. E.; Saouaf, O. M.; Ou, B. S.; Williams, S. C.; Eckman, N.; Irvine, D. J.; Appel, E.
10.1101/2024.07.05.602305 — bioengineering — Posted on 2024-12-20
1892 Engineered CRISPR-Base Editors as a Permanent Treatment for Familial Dysautonomia
Yun, S.; Chekuri, A.; Art, J.; Kondabolu, K.; Slaugenhaupt, S. A.; Zeltner, N.; Kleinstiver, B. P.; Morini, E.; Alves, C. R. R.
10.1101/2024.11.27.625322 — bioengineering — Posted on 2024-12-20
1893 Caspase-Activated DNase Localizes to Cancer Causing Translocation Breakpoints During Cell Differentiation
Alsowaida, D.; Larsen, B. D.; Hachmer, S.; Azimi, M.; Arezza, E.; Brunette, S.; Tur, S.; Palii, C. G.; Albraidy, B.; Sorensen, C. S.; Brand, M.; Dilworth, F. J.; Megeney, L. A.
10.1101/2024.09.24.614809 — genomics — Posted on 2024-12-20
1894 Unexpectedly low recombination rates and presence of hotspots in termite genomes
Everitt, T.; Ronneburg, T.; Elsner, D.; Olsson, A.; Liu, Y.; Larva, T.; Korb, J.; Webster, M. T.
10.1101/2024.03.22.586269 — genomics — Posted on 2024-12-20
1898 NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress
Amnekar, R.; Dite, T.; Lis, P.; Bell, S.; Brown, F.; Johnson, C.; Wilkinson, S.; Raggett, S.; Dorward, M.; Wightman, M.; Macartney, T.; Soares, R. F.; Lamoliatte, F.; Alessi, D. R.
10.1101/2024.12.12.628181 — cell biology — Posted on 2024-12-20
1899 The uptake of small extracellular vesicles by recipient cells is facilitated by paracrine adhesion signaling
Hirosawa, K. M.; Sato, Y.; Kasai, R. S.; Yamaguchi, E.; Komura, N.; Ando, H.; Hoshino, A.; Yokota, Y.; Suzuki, K. G. N.
10.1101/2024.04.11.589012 — cell biology — Posted on 2024-12-20
1901 MSLASpheroidStamp: 3d cell spheroids for everyone
Minin, A. S.; Semerikova, T.; Karavashkova, O.; Pozdina, V.; Tomilina, M.; Zubarev, I.; Belousova, A.
10.1101/2024.05.12.593682 — cell biology — Posted on 2024-12-20
1903 Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly
Colmenares, S. U.; Tsukamoto, S.; Hickmann, C.; Brennan, L. D.; Khavani, M.; Mofrad, M.; Karpen, G.
10.1101/2024.12.03.626544 — molecular biology — Posted on 2024-12-20
1904 Discovery and mechanistic characterization of a probiotic-origin 3β-OH-Δ5-6-cholesterol-5β-reductase directly converting cholesterol to coprostanol
Netter, U.; Bisht, V.; Gaurav, A.; Sharma, R.; Ghosh, A.; Bisht, V. S.; Ambatipudi, K.; Sharma, H. P.; Mohanty, S.; Loat, S.; Sarkar, M.; Tahlan, K.; Navani, N. K.
10.1101/2024.06.04.597308 — molecular biology — Posted on 2024-12-20
1905 UTX Epigenetically Imposes a Cytolytic Effector Program in Autoreactive Stem-like CD8+ T cell Progenitors
Chen, H.-C.; Wang, H. H.; Kohn, L. A.; Sailer, D.; Zhang, S.; McCarthy, E. C.; Seyedsadr, M.; Zhou, Z.; Yin, X.; Wilkinson, N. M.; Ortega, J.; Lechner, M. G.; Hugo, W.; Su, M. A.
10.1101/2024.12.12.628206 — immunology — Posted on 2024-12-20
1906 Distinct representational properties of cues and contexts shape fear learning and extinction
Bouyeure, A.; Pacheco, D.; Fellner, M.-C.; Jacob, G.; Kobelt, M.; Rose, J.; Axmacher, N.
10.1101/2024.12.16.628638 — neuroscience — Posted on 2024-12-19
1907 Induction of hemodynamic traveling waves by glial-related vasomotion in a rat model of neuroinflammation: implications for functional neuroimaging
Pereira, M.; Droguerre, M.; Valdebenito, M.; Vidal, L.; Marcy, G.; Benkeder, S.; Comte, J.-C.; Pascual, O.; Zimmer, L.; VIDAL, B.
10.1101/2024.12.13.628348 — neuroscience — Posted on 2024-12-19
1910 Reproducibility of in-vivo electrophysiological measurements in mice
The International Brain Laboratory, ; Banga, K.; Benson, J.; Bhagat, J.; Biderman, D.; Birman, D.; Bonacchi, N.; Bruijns, S. A.; Buchanan, K.; Campbell, R. A.; Carandini, M.; Chapuis, G. A.; Churchland, A. K.; Davatolhagh, M. F.; Lee, H. D.; Faulkner, M.; Gercek, B.; Hu, F.; Huntenburg, J. M.; Hurwitz, C.; Khanal, A.; Krasniak, C.; Langfield, C.; Lau, P.; Mackenzie, N.; Meijer, G. T.; Miska, N. J.; Mohammadi, Z.; Noel, J.-P.; Paninski, L.; Pan-Vazquez, A.; Rossant, C.; Roth, N.; Schartner, M.; Socha, K.; Steinmetz, N. A.; Svoboda, K.; Taheri, M.; Urai, A. E.; Wang, S.; Wells, M.; West, S. J.;
10.1101/2022.05.09.491042 — neuroscience — Posted on 2024-12-20
1912 A Brain-Wide Map of Neural Activity during Complex Behaviour
International Brain Lab, ; Benson, B.; Benson, J.; Birman, D.; Bonacchi, N.; Carandini, M.; Catarino, J. A.; Chapuis, G. A.; Churchland, A. K.; Dan, Y.; Dayan, P.; DeWitt, E. E.; Engel, T. A.; Fabbri, M.; Faulkner, M.; Fiete, I. R.; Findling, C.; Freitas-Silva, L.; Gercek, B.; Harris, K. D.; Hausser, M.; Hofer, S. B.; Hu, F.; Hubert, F.; Huntenburg, J. M.; Khanal, A.; Krasniak, C.; Langdon, C.; Lau, P. Y. P.; Mainen, Z. F.; Meijer, G. T.; Miska, N. J.; Mrsic-Flogel, T. D.; Noel, J.-P.; Nylund, K.; Pan-Vazquez, A.; Pouget, A.; Rossant, C.; Roth, N.; Schaeffer, R.; Schartner, M.; Shi, Y.; Socha
10.1101/2023.07.04.547681 — neuroscience — Posted on 2024-12-20
1914 Logic-based machine learning predicts how escitalopram attenuates cardiomyocyte hypertrophy
Eggertsen, T. G.; Travers, J. G.; Hardy, E. J.; Wolf, M. J.; McKinsey, T. A.; Saucerman, J. J.
10.1101/2024.11.13.623416 — systems biology — Posted on 2024-12-20
1915 AI-assisted decoding of molecular signatures essential for NON-PHOTOTROPIC HYPOCOTYL3 condensation and function in phototropism
Manishankar, P.; Reuter, L.; Rohr, L.; Fernandez, A.; Yigit, Y. I.; Schmidt, T.; Droste-Borel, I.; Keicher, J.; Bock, A.; Oecking, C.
10.1101/2024.06.17.598829 — plant biology — Posted on 2024-12-20
1919 Image-Guided Targeting of Mitochondrial Metabolism Sensitizes Pediatric Malignant Rhabdoid Tumors to Low Dose Radiotherapy
Xia, W.; Goff, M.; Schiavone, C.; Singh, N.; Huang, J.; Need, E.; Cave, J.; Gillespie, D.; Jensen, R.; Pagel, M.; Dogra, P.; Shi, S.; Goel, S.
10.1101/2024.08.09.607364 — bioengineering — Posted on 2024-12-20
1924 Spread of a single superclone drives insecticide resistance in Acyrthosiphon kondoi across an invasive range
Thia, J. A.; Hunt, B. J.; Wang, S.; Troczka, B. J.; Brown, C. J.; Arinanto, L. S.; Chirgwin, E.; Stelmach, M.; Richardson, K.; Joglekar, C.; Dorai, A. P.; Yang, Q.; Babineau, M.; Bass, C.; Hoffmann, A. A.; Umina, P. A.
10.1101/2024.12.16.628636 — evolutionary biology — Posted on 2024-12-19
1926 Independence of centromeric and pericentromeric chromatin stability on CCAN components
Biggs, R. J.; Marko, J. F.; Straight, A. F.; Sundararajan, K.; Sun, M.; Hendrix, E.
10.1101/2024.12.18.628896 — cell biology — Posted on 2024-12-19
1928 PAbFold: Linear Antibody Epitope Prediction using AlphaFold2
DeRoo, J.; Terry, J. S.; Zhao, N.; Stasevich, T. J.; Snow, C.; Geiss, B. J.
10.1101/2024.04.19.590298 — molecular biology — Posted on 2024-12-20
1929 Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants
Kiu, R.; Darby, E. M.; Alcon-Giner, C.; Acuna-Gonzalez, A.; Camargo, A.; Lamberte, L. E.; Sim, K.; Shaw, A. G.; Clarke, P.; van Schaik, W.; Kroll, J. S.; Hall, L. J.
10.1101/2024.12.18.629205 — microbiology — Posted on 2024-12-20
1930 Oral and faecal viromes of New Zealand calves on pasture with an idiopathic ill-thrift syndrome
Grimwood, R. M.; Darnley, J. A.; O'Connell, J. P.; Hunt, H.; Taylor, H.; Lawrence, K. E.; Abbott, M.; Jauregui, R.; Geoghegan, J. L.
10.1101/2024.12.18.629268 — microbiology — Posted on 2024-12-20
1931 CD24-Fc resolves inflammation and rescues CD8 T cells with polyfunctionality during HIV-1 infection under cART
Su, L.; Li, G.; Ma, J.; Yu, H.; Tsahouridis, O.; Lou, Y.; He, X.; Funaki, M.; Mathur, P.; Kottilil, S.; Zheng, P.; Liu, Y.
10.1101/2024.12.16.628615 — immunology — Posted on 2024-12-19
1932 Image Processing in the Acute to Chronic Pain Signatures (A2CPS) Project
Sadil, P.; Arfanakis, K.; Bhuiyan, E. H.; Caffo, B.; Calhoun, V. D.; Clauw, D. J.; DeLano, M. C.; Ford, J. C.; Gattu, R.; Guo, X.; Harris, R. E.; Ichesco, E.; Johnson, M. A.; Jung, H.; Kahn, A. B.; Kaplan, C. M.; Leloudas, N.; Lindquist, M. A.; Luo, Q.; Mulderink, T. A.; Peltier, S. J.; Prasad, P. V.; Sica, C.; Urrutia, J.; Vance, C. G.; Wager, T. D.; Xuan, Y.; Zhou, X. J.; Zhou, Y.; Shu, D. C.; The Acute to Chronic Pain Signatures Consortium,
10.1101/2024.12.19.627509 — neuroscience — Posted on 2024-12-20
1934 Correlative light and electron microscopy for human brain and other biological models
Shafiei, N.; Stahli, D.; Burger, D.; Di Fabrizio, M.; Van den Heuvel, L.; Daraspe, J.; Boing, C.; Shahmoradian, S. H.; van de Berg, W. D. J.; Genoud, C.; Stahlberg, H.; Lewis, A.
10.1101/2024.06.11.598271 — neuroscience — Posted on 2024-12-20
1939 Multispecies relations shape bird-feeding practices
Aivelo, T.; Aulio, M.; Enström, J.; Deshpande, P.; Haukka, A.; Lähdesmäki, H.; Rönkä, K.; Santangeli, A.; Väkkärä, V.; Lehikoinen, A.; Thorogood, R.; Kervinen, A.
10.1101/2024.12.19.629318 — scientific communication and education — Posted on 2024-12-20
1941 ParaSurf: A Surface-Based Deep Learning Approach for Paratope-Antigen Interaction Prediction
Papadopoulos, A. M.; Axenopoulos, A.; Iatrou, A.; Stamatopoulos, K.; Alvarez, F.; Daras, P.
10.1101/2024.12.16.628621 — bioinformatics — Posted on 2024-12-19
1943 An Emirati pangenome incorporating a diploid telomere-to-telomere reference
Olbrich, M. R.; Mousa, M.; Wohlers, I.; Aamri, A. A.; Alnaqbi, H.; Alsuwaidi, A. H.; Manoharan, H. V.; Marzouka, N. a.-d.; Ramachandran, S. E.; Thomas, A. A.; Alameri, M. S.; Tay, G.; Hamoudi, R. A.; Ibrahim, S.; Ghaithi, N. A.; Alsafar, H.
10.1101/2024.12.16.628631 — genomics — Posted on 2024-12-19
1947 The pseudoknot structure of a viral RNA reveals a conserved mechanism for programmed exoribonuclease resistance
Gezelle, J. G.; Korn, S. M.; McDonald, J. T.; Gong, Z.; Erickson, A.; Huang, C.-H.; Yang, F.; Cronin, M.; Kuo, Y.-W.; Wimberly, B. T.; Steckelberg, A.-L.
10.1101/2024.12.17.628992 — biochemistry — Posted on 2024-12-20
1948 Unlocking the genomic repertoire of a cultivated megaphage
Buchan, A.; Wiedman, S.; Lambirth, K.; Bellanger-Perry, M.; Figueroa, J. L.; Wright, E. T.; Suresh, P. S.; Zhang, Q.; Thomas, J. A.; Serwer, P.; White, R. A.
10.1101/2024.12.16.628780 — microbiology — Posted on 2024-12-20
1949 Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm
Wojnowska, M.; Wajima, T.; Yelland, T.; Ludewig, H.; Hagan, R. M.; Watt, G.; Hamaia, S. W.; Bihan, D.; Malcor, J.-D.; Bonna, A.; Bergsten, H.; Svensson, M.; Oppegaard, O.; Skrede, S.; Arnell, P.; Hyldegaard, O.; Farndale, R. W.; Norrby-Teglund, A.; Schwarz-Linek, U.
10.1101/2024.12.17.628954 — microbiology — Posted on 2024-12-20
1950 Metabolic rerouting by gain-of-function mutations overcomes plsX essentiality in Staphylococcus aureus
Gruss, A.; Wongdontree, P.; Palmier, M.; Leguillier, V.; Gloux, K.; Halpern, D.; Anba-Mondoloni, J.
10.1101/2024.12.18.629266 — microbiology — Posted on 2024-12-20
1951 Expanding the Landscape of Aging via Orbitrap Astral Mass Spectrometry and Tandem Mass Tag (TMT) Integration
Keele, G. R.; Dou, Y.; Kodikara, S. P.; Jeffery, E. D.; Bai, D.; Paulo, J. A.; Gygi, S. P.; Tian, X.; Zhang, T.
10.1101/2024.12.13.628374 — systems biology — Posted on 2024-12-20
1955 Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration
Song, Y.; Wang, Q.; Miles, L.; Wang, S.; Noristani, H. N. N.; Vargas, E. J. M.; Powell, J.; O'Rourke-Ibach, S. J.; Li, S.
10.1101/2024.12.13.628292 — neuroscience — Posted on 2024-12-20
1958 A comparative analysis of toxin gene families across diverse sea anemone species
Smith, H. L.; Broszczak, D. A.; van der Burg, C. A.; Surm, J. M.; Liggins, L.; Norton, R. S.; Prentis, P. J.
10.1101/2024.12.13.628455 — genetics — Posted on 2024-12-20
1960 Prediction of peptide structural conformations with AlphaFold2
Ille, A. M.; Markosian, C.; Burley, S. K.; Pasqualini, R.; Arap, W.
10.1101/2024.12.03.626727 — bioinformatics — Posted on 2024-12-20
1961 The muscarinic acetylcholine receptor in dermal papilla cells regulates hair growth
Yuen, G. K.-W.; Leung, K.-W.; Lai, Q. W.-S.; Guo, M. S.; Gao, X.; Ho, J. Y.-M.; Chu, H. C.-T.; Tsim, K. W.-K.
10.1101/2024.04.26.591334 — neuroscience — Posted on 2024-12-19
1964 Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness
Pawar, A. S.; Somers, P.; Alex, A.; George, S. S.; Antony, C.; Verner, R.; White-Brown, S. K.; Khera, M.; Mendoza-Figueroa, M. S.; Liu, K. F.; Morrissette, J. J. D.; Paralkar, V. R.
10.1101/2024.11.29.625909 — cancer biology — Posted on 2024-12-19
1965 A role for JAK2 in mediating cell surface GHR-PRLR interaction
Chen, C.; Jiang, J.; Rao, T. C.; Liu, Y.; Marquez Lago, T. T.; Frank, S. J.; Leier, A.
10.1101/2023.09.01.555812 — biophysics — Posted on 2024-12-19
1967 In silico design of stable single-domain antibodies with high affinity
Van Der Kant, R.; Zhang, Z.; Markovic, I.; Vizarraga, D.; Garcia, T.; Maragkou, K.; Delgado Blanco, J.; Cianferoni, D.; Orlando, G.; Cia, G.; Geukens, N.; Carolis, C.; Volkov, A. N.; Savvides, S. N.; DeWilde, M.; Schymkowitz, J.; Serrano Pubul, L.; Rousseau, F.
10.1101/2024.04.22.589762 — bioinformatics — Posted on 2024-12-19
1969 CRISPR screening by AAV episome-sequencing (CrAAVe-seq) is a highly scalable cell type-specific in vivo screening platform
Ramani, B.; Rose, I. V. L.; Teyssier, N.; Pan, A.; Danner-Bocks, S.; Sanghal, T.; Yadanar, L.; Tian, R.; Ma, K.; Palop, J. J.; Kampmann, M.
10.1101/2023.06.13.544831 — genomics — Posted on 2024-12-19
1970 Functional Imaging of Developing Brain in Mice and Non-Human Primates
ZHU, J.; He, D.; Sun, M.; Zheng, H.; Chen, Z.; Yang, J.; Lin, C.; Shi, Y. S.; Yuan, Q.; SUN, L.; Qiu, Z.
10.1101/2024.06.07.596778 — developmental biology — Posted on 2024-12-19
1972 Identification of Myeloid Protein Kinase C - Epsilon as a Novel Atheroprotective Gene
Wells, A. T.; Shen, M. M.; Binrouf, R. H.; D'Amico, A. E.; Bossardi Ramos, R.; Lennartz, M. R.
10.1101/2024.12.09.627650 — immunology — Posted on 2024-12-19
1973 Pore formation at the lytic synapse triggers the canonical pyroptotic cell death pathway
McKenzie, B.; Puissegur, M.-P.; Demeersseman, L.; Rodriguez, F.; Cini, E.; Bernand, A.; Mueller, S.; Valitutti, S.
10.1101/2024.05.24.595698 — immunology — Posted on 2024-12-19
1974 Microglia signals to fibroblasts and neural progenitor cells to control regenerative neurogenesis after spinal cord injury in zebrafish
Docampo Seara, A.; Cosacak, M. I.; Heilemann, K.; Kessel, F.; Oprisoreanu, A. M.; Westphal, M.; Cark, O.; Zoeller, D.; Arnold, J.; Bretschneider, A.; Hnatiuk, A.; Ninov, N.; Becker, C. G.; Becker, T.
10.1101/2024.10.16.618445 — neuroscience — Posted on 2024-12-19
1976 Decoding Brain Structure-Function Dynamics in Health and in Psychosis: A Tale of Two Models
Cai, Q.; Thomas, H.; Hyde, V.; Luque Laguna, P.; McNabb, C. B.; Singh, K. D.; Jones, D. K.; Messaritaki, E.
10.1101/2024.10.03.616264 — neuroscience — Posted on 2024-12-19
1977 Arousal threshold reveals novel neural markers of sleep depth independently from the conventional sleep stages
Picchioni, D.; Yang, F. N.; de Zwart, J. A.; Wang, Y.; Mandelkow, H.; Ozbay, P. S.; Chen, G.; Taylor, P. A.; Lam, N.; Chappel-Farley, M. G.; Chang, C.; Liu, J.; van Gelderen, P.; Duyn, J. H.
10.1101/2024.08.09.607376 — neuroscience — Posted on 2024-12-19
1979 POLARIS is a copper-binding peptide required for ethylene signalling control in Arabidopsis.
Mudge, A. M.; Mehdi, S.; Michaels, W. E.; Oroza-Puente, B.; Shen, W.; Tomlinson, C.; Wei, W.; Hoppen, C.; Uzun, B.; Roy, D.; Hetherington, F. M.; Topping, J. F.; Sadanandom, A.; Groth, G.; Robinson, N. J.; Lindsey, K.
10.1101/2023.06.15.545071 — plant biology — Posted on 2024-12-19
1981 In vivo targeted and deterministic single cell malignant transformation
Scerbo, P.; Tisserand, B.; Delagrange, M.; Debare, H.; Bensimon, D.; Ducos, B.
10.1101/2024.01.30.577941 — cancer biology — Posted on 2024-12-19
1982 A novel pan class-I glucose transporter inhibitor DRB18 exhibits synergistic effects in vitro and in vivo with paclitaxel against human non-small cell lung cancer
Shriwas, P.; Bachmann, L.; Ward, R.; Adhicary, S.; Nielsen, C. M.; Li, Y.; Zhang, H.; Song, J.; Roberts, D.; Bergmeier, S.; Chen, X.
10.1101/2024.12.15.628558 — cancer biology — Posted on 2024-12-19
1985 The cysteine-reactive covalent RNF4 ligand CCW16 induces ferroptosis in AML cells by activation of ROS signaling
Gotthardt, G.; Weckesser, J.; Tascher, G.; Barros da Gama, S.; Uckelmann, H. J.; Schwalm, M. P.; Mosler, T.; Ferrario, G.; Muench, C.; Knapp, S.; Mueller, S.
10.1101/2024.12.12.628083 — cell biology — Posted on 2024-12-19
1986 Of mice and men: Dendritic architecture differentiates human from mice neuronal networks
Kanari, L.; Shi, Y.; Arnaudon, A.; Barros Zulaica, N.; Benavides-Piccione, R.; Coggan, J. S.; DeFelipe, J. D.; Hess, K.; Mansvelder, H.; Mertens, E. J.; Meystre, J.; Perin, R. d. C.; Pezzoli, M.; Daniel, R. T.; Stoop, R.; Segev, I.; Markram, H.; de Kock, C. P.
10.1101/2023.09.11.557170 — neuroscience — Posted on 2024-12-19
1987 Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles
Moodie, J. E.; Buchanan, C. R.; Furtjes, A.; Conole, E. L. S.; Stolicyn, A.; Corley, J.; Ferguson, K.; Hernandez, M. V.; Maniega, S. M.; Russ, T. C.; Luciano, M. C.; Whalley, H. C.; Bastin, M. E.; Wardlaw, J.; Deary, I.; Cox, S. R.
10.1101/2024.12.17.628670 — neuroscience — Posted on 2024-12-19
1990 Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases
Shwab, E. K.; Man, Z.; Gingerich, D. C.; Gamache, J. E.; Garrett, M. E.; Serrano, G. E.; Beach, T. G.; Crawford, G. E.; Ashley-Koch, A. E.; Chiba-Falek, O.
10.1101/2024.12.13.628436 — neuroscience — Posted on 2024-12-18
1991 The diffusion of cooperative and solo bubble net feeding in Canadian Pacific humpback whales
Wray, J.; O'Mahony, E. N.; Baer, G.; Robinson, N.; Dundas, A.; Gaggiotti, O. E.; Rendell, L.; Keen, E.
10.1101/2024.12.12.628166 — animal behavior and cognition — Posted on 2024-12-18
1992 Widespread occurrence of benzimidazole resistance single nucleotide polymorphisms in the canine hookworm, Ancylostoma caninum, in Australia
Abdullah, S.; Stocker, T.; Kang, H.; Scott, I.; Hayward, D.; Jaensch, S.; Ward, M.; Jones, M. K.; Kotze, A.; Slapeta, J.
10.1101/2024.09.05.611542 — microbiology — Posted on 2024-12-18
1997 UTX Epigenetically Imposes a Cytolytic Effector Program in Autoreactive Stem-like CD8+ T cell Progenitors
Chen, H.-C.; Wang, H. H.; Kohn, L. A.; Sailer, D.; Zhang, S.; McCarthy, E.; Seyedsadr, M.; Zhou, Z.; Yin, X.; Wilkinson, N.; Ortega, J.; Lechner, M. G.; Hugo, W.; Su, M.
10.1101/2024.12.12.628206 — immunology — Posted on 2024-12-18
2000 ABHD2 activity is not required for the non-genomic action of progesterone on human sperm
Arnolds, O.; Carter, E. M.; Edwards, M.; Wigren, E.; Homan, E.; Ribera, P.; Bentley, K.; Haraldsson, M.; Theo-Emegano, N.; Loppnau, P.; Szewczyk, M. M.; Cao, M. A.; Barsyte-Lovejoy, D.; Vester, K.; Thrun, A.; Amaral, A.; Lesche, R.; Münchow, J.; Zhu, W. F.; Temme, L.; Brenker, C.; Strünker, T.; Sundström, M.; Todd, M. H.; Edwards, A. M.; Tredup, C.; Gileadi, O.
10.1101/2024.12.17.628646 — cell biology — Posted on 2024-12-18
2001 TGF-β expressed by M2 macrophages promotes wound healing by inhibiting TSG-6 expression by mesenchymal stem cells
Eom, Y. W.; Hong, J.-E.; Jung, P. Y.; Yoon, Y.; Yoo, S.-H.; Hong, J.; Rhee, K.-J.; Regmi, B.; Fatima, S.; Kim, M. Y.; Baik, S. K.; Kwon, H. Y.
10.1101/2024.12.17.629006 — cell biology — Posted on 2024-12-18
2002 The transcriptomic signature of age and sex is not conserved in human primary myocytes
Lamon, S.; Soria, M.; Williams, R. M.; Critchlow, A.; Garnham, A.; Varshney, A.; Beilharz, T.; Hiam, D.; Ziemann, M.
10.1101/2024.12.17.629041 — cell biology — Posted on 2024-12-18
2003 Hyperactive PLCG1 drives non-canonical signaling to promote cell survival
Zeng, L.; Zhang, X.; Xiong, Y.; Sato, K.; Hajicek, N.; Sondek, J.; Su, X.
10.1101/2024.12.17.628879 — cell biology — Posted on 2024-12-18
2004 A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular ASO activity
Malong, L.; Roskosch, J.; Hager, C.; Fortin, J.-P.; Schmucki, R.; Callow, M. G.; Weile, C.; Romeo, V.; Patsch, C.; Martin, S.; Costa, M.; Modrusan, Z.; Villasenor, R.; Koller, E.; Haley, B.; Spang, A.; Roudnicky, F.
10.1101/2024.12.17.628665 — cell biology — Posted on 2024-12-18
2007 Virus-induced vesicular acidification enhances HIV immune evasion.
Yaple-Maresh, M. E.; Flores, G. G.; Zimmerman, G. E.; Gomez-Rivera, F.; Collins, K. L.
10.1101/2024.12.17.628989 — cell biology — Posted on 2024-12-18
2009 The physiological impact of an N-terminal Halo-tag on GIPR function in mice
Davies, I.; Manchanda, Y.; Sloop, K. W.; Bloom, S. R.; Tan, T. M.; Tomas, A.; Jones, B.
10.1101/2024.12.18.629103 — cell biology — Posted on 2024-12-18
2013 Injured endocardium obtains characteristics of haemogenic endothelium during adult zebrafish heart regeneration
Ying, J.; Louca, I.; Koth, J.; Killen, A. C.; Lekkos, K.; Hu, Z.; Sengul, E.; Stockdale, W. T.; Wang, X.; Mommersteeg, M. T. M.
10.1101/2024.12.18.629122 — developmental biology — Posted on 2024-12-18
2014 Muscle growth by sarcomere divisions
Rodier, C.; Estabrook, I. D.; Chan, E. H.; Rice, G.; Loreau, V.; Raunser, S.; Goerlich, D.; Friedrich, B. M.; Schnorrer, F.
10.1101/2024.12.18.629106 — developmental biology — Posted on 2024-12-18
2017 PARP inhibitor counteracts Temozolomide Resistance in Glioblastoma Multiforme
Samarut, E.; Tabourel, G.; Briand, J.; Landais, Y.; Gratas, C.; Cartron, P.-F.; Vallette, F.; Oliver, L.; Serandour, A. A.
10.1101/2024.12.13.627927 — cancer biology — Posted on 2024-12-18
2019 Investigating microscopic angioarchitecture in the human visual cortex in 3D with angioMASH tissue clearing and labelling
Hildebrand, S.; Franz, J.; Hoogen, H.; Capalbo, M.; Bethge, P.; Herrler, A.; Helmchen, F.; Roebroeck, A.
10.1101/2024.08.26.609648 — neuroscience — Posted on 2024-12-18
2020 Early endosome disturbance and endolysosomal pathway dysfunction in Duchenne muscular dystrophy
Chassagne, J.; Da Silva, N.; Akrouf, I.; Cadot, B.; Julien, L.; Barthelemy, I.; Blot, S.; Le Guiner, C.; Bui, M. T.; Romero, N. B.; Laine, J.; Pietri-Rouxel, F.; Meunier, P.; Mamchaoui, K.; Lorain, S.; Bitoun, M.; Benkhelifa-Ziyyat, S.
10.1101/2024.12.16.628552 — pathology — Posted on 2024-12-18
2021 Circulating tumor cells shed large extracellular vesicles in capillary-sized bifurcations
Vrynas, A.; Arfan, S.; Satia, K.; Bazban-Shotorbani, S.; Ashna, M.; Zhang, A.; Visan, D.; Chen, A.; Carter, M.; Blackhall, F.; Simpson, K.; Dive, C.; Huang, P. H.; Au, S. H.
10.1101/2024.04.17.589880 — cancer biology — Posted on 2024-12-18
2022 Deep Learning-Driven Subtype Classification of Colorectal Cancer Using Histopathology Images for Personalized Medicine
Trong Le Phan, N.; Fortune Mavuso, M.; Nguyen Thien Dao, P.; Ngoc Anh Nguyen, H.; Thuy Mai, T.; Thi Quang, K.; Truong Le, T.
10.1101/2024.12.12.628270 — cancer biology — Posted on 2024-12-18
2027 Identification of novel toxin domains and characterization of a broadly distributed family of lipid-targeting NlpC/P60.
Nicastro, G. G.; Sibinelli-Sousa, S.; Hespanhol, J. T.; Santos, T. W.; Munoz, J. P.; Santos, R. S.; Perez-Sepulveda, B. M.; Miyamoto, S.; Aravind, L.; de Souza, R. F.; Bayer-Santos, E.
10.1101/2024.09.27.615498 — microbiology — Posted on 2024-12-18
2028 A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide
Wang, Z.; Ojogun, N.; Liu, Y.; Gan, L.; Xiao, Z.; Feng, J.; Jiang, W.; Chen, Y.; Zou, B.; Yu, C.; Li, C.; Ashuo, A.; Li, X.; Fu, M.; Wu, J.; Chu, Y.; Munford, MD, R. S.; Lu, M.
10.1101/2024.06.23.600304 — immunology — Posted on 2024-12-18
2031 Role of ERK2 dimerization in synaptic plasticity and memory
Ojea Ramos, S.; Medina, C.; Krwczyk, M. d. C.; Millan, J.; Acutain, M. F.; Romano, A.; Baez, M. V.; Urbano, F.; Boccia, M. M.; Feld, M.
10.1101/2024.09.06.611755 — neuroscience — Posted on 2024-12-18
2034 A general strategy for generating expert-guided, simplified views of ontologies
Caron, A. R.; Puig-Barbe, A.; Quardokus, E. M.; Hardi, J.; Balhoff, J. P.; Belfiore, J.; Chipampe, N.-J.; Herr, B. W.; Kir, H.; Musen, M. A.; Roncaglia, P.; McLaughlin, J.; Borner, K.; Osumi-Sutherland, D.
10.1101/2024.12.13.628309 — bioinformatics — Posted on 2024-12-18
2035 Direct expression of CPT1a enables a high throughput platform for the discovery of CPT1a modulators
Chen, J.; Tran, T.; Wong, A. J.-h.; Wang, L.; Annaluru, P. S.; Sreekanth, V.; Murthy, S.; Munjeti, L. S.; Park, T.; Bhat, U. A.; Leong, G. E.; Li, Y.; Chen, S.; Kong, N. J.; Raval, R. K.; Xie, Y. F.; Somani, S.; Bhambhani, A. M.; Zhu, Z. R.; Chu, L. M.; Dosch, K.; Njoo, E.; Chen, Z.
10.1101/2024.12.15.628575 — biochemistry — Posted on 2024-12-18
2037 Differential metabolic biomarkers between coronary heart disease and diabetes mellitus
Wang, Z.; cang, y.; Shi, F.; Zhang, Y.; Cui, H.-N.; He, Y.; Liu, L.; Li, Y.; Xu, Y.; Wen, H.; Liu, Z.
10.1101/2024.12.16.628812 — molecular biology — Posted on 2024-12-18
2040 Modelling oxaliplatin resistance in colorectal cancer reveals a SERPINE1-based gene signature (RESIST-M) and therapeutic strategies for pro-metastatic CMS4 subtype
Wong, S. Q. R.; Das, M.; Shirgaonkar, N.; Tenzin, K.; Chua, H.; Xuan Chee, L.; Yeoh Ahpa, S.; Aruna Murugiah, A.; Yong Chua, W.; Skolastika Theardy, M.; Thangavelu Thangavelu, M.; Vin Chan, J.; Kong Yap, C.; Tan, I. B. H.; Tsantoulis, P.; Tejpar, S.; Min Loo, J.; Dasgupta, R.
10.1101/2024.12.17.628817 — cancer biology — Posted on 2024-12-18
2042 Genomic Diversity and Antimicrobial Resistance of Vibrio cholerae Isolates from Africa: A PulseNet Africa Initiative Using Nanopore Sequencing to Enhance Genomic Surveillance
Foster-Nyarko, E.; Able-Thomas, S.; Adade, N. E.; Adade, R.; Anne, J. C. B.; Antwi, L.; Bah, Y.; Boateng, G.; Carleton, H.; Chaima, D.; Chilengi, R.; Coulibaly, K. J.; Derra, F. A.; Didon, D.; Dimuna, C.; Dosso, M.; Drammeh, M. M.; Ferjani, S.; Holt, K. E.; Jatta, R.; Kalule, J. B.; Kanteh, A.; Kette, H. F.; Khan, D.; Kouadio, N. K. N.; Lee, C.; Mantina, H.; Mulenga, G.; Mwaba, J.; Nyang, F.; Owusu-Okyere, G.; Rowland, J.; Seck, A.; Sesay, A. K.; Smith, A.; Smith, P.; Soma, D.; Tau, N.; Tchuint, P. L. S.; Tientcheu, P.-E. M.; Sokoni, C.; Vakou, S. N.; Vubil, D.; PulseNet Africa,
10.1101/2024.12.17.628868 — genomics — Posted on 2024-12-18
2045 Clathrins are involved in the endocytosis of host cytosol in the malaria parasite
Miao, J.; Ning, G.; Xia, X.; Liang, X.; Lucky, A. B.; Siddiqui, F. A.; Min, H.; Wang, C.; Li, X.; Zhou, H.; Cui, L.
10.1101/2024.12.17.629030 — microbiology — Posted on 2024-12-18
2050 Mechanism of D-type cyclins recognition by the AMBRA1 E3 ligase receptor
Wang, Y.; Liu, M.; Wang, S.; Mai, X.; Wang, X.; Teng, F.; Lyu, T.; Su, M.-Y.; Stjepanovic, G.
10.1101/2024.12.17.628619 — biochemistry — Posted on 2024-12-18
2051 Dosage compensation of transposable elements in mammals
Wei, C.; Kesner, B.; Weissbein, U.; Wasserzug-Pash, P.; Das, P.; Lee, J. T.
10.1101/2024.12.16.628797 — genetics — Posted on 2024-12-18
2052 Transposable elements drive regulatory and functional innovation of F-box genes
Almeida, M. V.; Li, Z.; Rebelo-Guiomar, P.; Dallaire, A.; Fiedler, L.; Price, J.; Sluka, J.; Liu, X.; Butter, F.; Rodelsperger, C.; Miska, E. A.
10.1101/2024.12.17.628972 — evolutionary biology — Posted on 2024-12-18
2056 Coupling CRISPR Scanning with Targeted Chromatin Accessibility Profiling using a Double-Stranded DNA Deaminase
Roh, H.; Shen, S. P.; Hu, Y.; Kwok, H. S.; Siegenfeld, A. P.; Lee, C.; Zepeda, M.; Guo, C.-J.; Roseman, S. A.; Sankaran, V. G.; Buenrostro, J. D.; Liau, B. B.
10.1101/2024.12.17.628791 — molecular biology — Posted on 2024-12-18
2058 Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine.
Bilardi, R. A.; Flensburg, C.; Xu, Z.; Derrick, E. B.; Kueh, A.; Majewski, I. J.
10.1101/2024.12.17.628571 — molecular biology — Posted on 2024-12-18
2060 Hexosamine Biosynthesis Disruption Impairs GPI Production and Arrests Plasmodium falciparum Growth at Schizont Stages
Alberione, M. P.; Avalos-Padilla, Y.; Rangel, G. W.; Ramirez, M.; Romero-Urunuela, T.; Fenollar, A.; Crispim, M.; Smith, T. K.; Llinas, M.; Izquierdo, L.
10.1101/2024.12.18.629086 — microbiology — Posted on 2024-12-18
2064 Antibiotics that Kill Gram-negative Bacteria by Restructuring the Outer Membrane Protein BamA
Modaresi, S. M.; Sugiyama, R.; Tram, N. D. T.; Jakob, R. P.; Phan, C.-S.; Saei, A. A.; Morishita, Y.; Muehlethaler, T.; Lim, J.; Ritz, D.; Long, P. S. Y.; Lehner, P. A.; Lim, Z. H.; Degen, M.; Yao, Z.; Maier, T.; Hou, Y.; Lee, J. Y.; Xu, J.; Yeat, A. Y. J.; Koh, K. T. S.; Goh, W. Y.; Ling, S. Y. H.; Chua, P. W. L.; Yamazaki, M.; Ee, P. L. R.; Hiller, S.; Morinaka, B. I.
10.1101/2024.12.16.628070 — microbiology — Posted on 2024-12-18
2065 Erythrocytic plasma membrane calcium ATPase (PMCA4b) variations mediate redox imbalance to determine artemisinin sensitivity in malaria
Agrohi, P.; Garg, S.; Biswas, S.; Maurya, P.; Kumar, V.; Goswami, B.; Sil, S. K.; Singh, M. P.; Chand, S. K.; Shalini, S.; Singh, O. P.; Dhangadamajhi, G.; Ramalingam, S.; Mallick, P. K.; singh, s.
10.1101/2024.12.17.628803 — microbiology — Posted on 2024-12-18
2067 Microbial alginate foraging is conserved in geographically and taxonomically distinct ruminant microbiomes
Ferrillo, A.; Tingley, J. P.; King, M. L.; Sagaye, A.; Bajwa, B.; Xing, X.; Johannessen, T.; Lysberg, A.; Mydland, L. T.; Overland, M.; Reintjes, G.; Shearer, A. Y.; Klassen, L.; Low, K. E.; Patel, T. R.; Terry, S.; Pope, P. B.; Abbott, D. W.; Hagen, L. H.
10.1101/2024.12.17.628917 — microbiology — Posted on 2024-12-18
2071 A protein cage system for producing bioactive peptides in Escherichia coli
Harding, M. D.; Jackson, M. A.; Gilding, E. K.; Yap, K.; Craik, D. J.; Sainsbury, F.; Lawrence, N.
10.1101/2024.12.16.628579 — synthetic biology — Posted on 2024-12-18
2075 A three-dimensional histological cell atlas of the developing human brain
Jayakumar, J.; Sivaprakasam, M.; Verma, R.; Bota, M.; Joseph, J.; Mulay, S.; Kumutha, J.; Srinivasan, C.; S, S.; S, L.; Kumar, H. E.; Bhaduri, A.; Nowakowski, T. J.; Roy, P. K.; Savoia, S.; Banerjee, S.; Tward, D.; Mitra, P. P.
10.1101/2024.12.17.628811 — neuroscience — Posted on 2024-12-18
2076 Genomic diversity of the African malaria vector Anopheles funestus
Bodde, M.; Nwezeobi, J.; Korlevic, P.; Makunin, A.; Akone-Ella, O.; Barasa, S.; Gadji, M.; Hart, L.; Kaindoa, E. W.; Love, K.; Lucas, E. R.; Lujumba, I.; Maquina, M.; Nagi, S.; Odero, J. O.; Polo, B.; Sangbakembi, C.; Dadzie, S.; Koekemoer, L. L.; Kwiatkowski, D.; McAlister, E.; Ochomo, E.; Okumu, F.; Paaijmans, K.; Tchouassi, D. P.; Wondji, C. S.; Ayala, D.; Durbin, R.; Miles, A.; Lawniczak, M. K.
10.1101/2024.12.14.628470 — genomics — Posted on 2024-12-18
2079 Epigenetic control of metabolic identity across cell types
Pacheco, M. P.; Gerard, D.; Mangan, R. J.; Chapman, A. R.; Hecker, D.; Kellis, M.; Schulz, M. H.; Sinkkonen, L.; Sauter, T.
10.1101/2024.07.24.604914 — systems biology — Posted on 2024-12-18
2080 PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP
Wang, J.; Shi, Y.; Wang, Y.; Shen, Y.; Liu, H.; Sun, S.; Wang, Y.; Zhou, X.; Zhou, Y.; Zeng, X.; Li, J.; Chen, Q.
10.1101/2024.07.23.604769 — cancer biology — Posted on 2024-12-18
2081 Chloride binding to prestin does not influence very high-frequency complex nonlinear capacitance (cNLC) in the mouse outer hair cell
Bai, J.-P.; Zhang, C.; Bahader, I.; Strenzke, N.; Renigunta, V.; Oliver, D.; Navaratnam, D. S.; Beckstein, O.; Santos-Sacchi, J.
10.1101/2024.01.29.577264 — biophysics — Posted on 2024-12-17
2082 Exploring Genetic Interactions with Rare Variants Reveals Gene Networks Susceptible to Complex Diseases
Jiang, H.; Tang, B.; Li, K.; Zhang, L.; Liang, J.; Tang, C. S.-M.; Tam, P. K.-H.; Wang, B.; Song, Y.; Wang, Q.; Li, M. J.; Huang, H.; LI, M.
10.1101/2024.12.17.628845 — bioinformatics — Posted on 2024-12-17
2083 A versatile information retrieval framework for evaluating profile strength and similarity
Kalinin, A. A.; Arevalo, J.; Vulliard, L.; Serrano, E.; Tsang, H.; Bornholdt, M.; Sivagurunathan, S.; Rajwa, B.; Carpenter, A. E.; Way, G. P.; Singh, S.
10.1101/2024.04.01.587631 — bioinformatics — Posted on 2024-12-17
2085 In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium
Hass, D. T.; Giering, E.; Han, J. Y. S.; Bisbach, C. M.; Pandey, K.; Robbings, B. M.; Mundinger, T. O.; Nolan, N. D.; Tsang, S. H.; Philp, N. J.; Peachey, N. S.; Hurley, J. B.
10.1101/2023.04.10.536306 — biochemistry — Posted on 2024-12-18
2087 Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation on gene expression and DNA methylation
Billingsley, K. J.; Meredith, M.; Daida, K.; Alvarez Jerez, P.; Negi, S.; Malik, L.; Genner, R. M.; Moller, A.; Zheng, X.; Gibson, S. B.; Mastoras, M.; Baker, B.; Kouam, C.; Paquette, K.; Jarreau, P.; Makarious, M. B.; Moore, A.; Hong, S.; Vitale, D.; Shah, S.; Monlong, J.; Pantazis, C. B.; Asri, M.; Shafin, K.; Carnevali, P.; Marenco, S.; Auluck, P.; Mandal, A.; Miga, K. H.; Rhie, A.; Reed, X.; Ding, J.; Cookson, M. R.; Nalls, M.; Singleton, A.; Miller, D. E.; Chaisson, M.; Timp, W.; Gibbs, J. R.; Phillippy, A. M.; Kolmogorov, M.; Jain, M.; Sedlazeck, F. J.; Paten, B.; Blauwendraat, C.
10.1101/2024.12.16.628723 — genomics — Posted on 2024-12-18
2088 Molecular evolution of a reproductive barrier in maize and related species
Cryan, E.; Phinney, G.; Seetharam, A. S.; Evans, M. M. S.; Kellogg, E. A.; Zhan, J.; Meyers, B. C.; Kliebenstein, D. J.; Ross-Ibarra, J.
10.1101/2024.12.02.626474 — genetics — Posted on 2024-12-17
2092 The Blueprint for Survival: The Blue Dasher Dragonfly as a Model for Urban Adaptation
Tolman, E. R.; Gamett, E.; Beatty, C. D.; Goodman, A.; Hahn, B.; Benischek, C.; Castillo, G.; Derdarian, E.; Fernandez-Juarez, S.; Gallafent, B.; Jenson, J.; Jordan, D.; Schneider, M.; Salazar, R.; Tamano, T.; Wei, M.; Idec, J.; Guralnick, R.; Ware, J. L.; Kohli, M. K.
10.1101/2024.12.12.628234 — evolutionary biology — Posted on 2024-12-17
2093 Relevance of the synergy of surveillance and populational networks in understanding the Usutu virus outbreak within common blackbirds (Turdus merula) in Metropolitan France, 2018
Bouchez-Zacria, M.; Calenge, C.; Villers, A.; Lecollinet, S.; Gonzalez, G.; Quintard, B.; Leclerc, A.; Baurier, F.; Paty, M.-C.; Faure, E.; Eraud, C.; Decors, A.
10.1101/2024.07.22.604715 — ecology — Posted on 2024-12-18
2095 Spatial transcriptomics in the adult Drosophila brain and body
Janssens, J.; Mangeol, P.; Hecker, N.; Partel, G.; Spanier, K.; Ismail, J. N.; Hulselmans, G. J.; Aerts, S.; Schnorrer, F.
10.1101/2023.10.06.561233 — developmental biology — Posted on 2024-12-17
2098 Spatial evidence of cryptic methane cycling and methylotrophic metabolisms along a land-ocean transect in a California coastal wetland
Krause, S. J. E.; Wipfler, R. L.; Liu, J.; Yousavich, D. J.; Robinson, D.; Hoyt, D. W.; Orphan, V. J.; Treude, T.
10.1101/2024.07.16.603764 — microbiology — Posted on 2024-12-17
2099 Evolutionary rescue of spherical mreB deletion mutants of the rod-shape bacterium Pseudomonas fluorescens SBW25
Yulo, P. R.; Desprat, N.; Gerth, M. L.; Ritzl-Rinkenberger, B.; Farr, A. D.; Liu, Y.; Zhang, X.-X.; Miller, M.; Cava, F.; Rainey, P. B.; Hendrickson, H. L.
10.1101/263681 — microbiology — Posted on 2024-12-17
2100 Role of sortase-assembled Ebp pili in Enterococcus faecalis adhesion to iron oxides and its impact on extracellular electron transfer
Ho, F. K.; Lam, L. N.; Matysik, A.; Watts, T. D.; Wong, J. J.; Chong, K. K. L.; Choo, P. Y.; Tolar, J.; Low, P. M.; Chua, Z. S.; Paxman, J. J.; Heras, B.; Marsili, E.; Ajo-Franklin, C. M.; Kline, K. A.
10.1101/601666 — microbiology — Posted on 2024-12-18
2103 Lifespan Normative Modeling of Brain Microstructure
Reina, J. E. V.; Zhu, A. H.; Benavidez, S.; Moreau, C. E.; Feng, Y.; Chattopadhyay, T.; Nabulsi, L.; Kushan, L.; John, J. P.; Joshi, H.; Thomopoulos, S. I.; Lawrence, K. E.; Nir, T. M.; Jahanshad, N.; Bearden, C. E.; Kia, S. M.; Marquand, A. F.; Thompson, P. M.; Alzheimer's Disease Neuroimaging Initiative,
10.1101/2024.12.15.628527 — neuroscience — Posted on 2024-12-17
2104 Longitudinal Investigation of Neurobiological Changes Across Pregnancy
Niu, Y.; Conrad, B. N.; Camacho, M. C.; Ravi, S.; Piersiak, H. A.; Bailes, L. G.; Barnett, W.; Manhard, M. K.; Cole, D. A.; Clayton, E. W.; Osmundson, S. S.; Smith, S. A.; Kujawa, A.; Humphreys, K. L.
10.1101/2024.03.08.584178 — neuroscience — Posted on 2024-12-17
2110 The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus
Nikhil, K. L.; Singhal, B.; Granados-Fuentes, D.; Li, J.-S.; Kiss, I. Z.; Herzog, E. D.
10.1101/2024.12.06.627294 — neuroscience — Posted on 2024-12-17
2111 A stress-dependent TDP-43 SUMOylation program preserves neuronal function
Suk, T. R.; Part, C. E.; Zhang, J. L.; Nguyen, T. T.; Heer, M. M.; Caballero-Gomez, A.; Grybas, V. S.; McKeever, P. M.; Nguyen, B.; Callaghan, S. M.; Woulfe, J. M.; Robertson, J.; Rousseaux, M. W. C.
10.1101/2024.04.12.589206 — neuroscience — Posted on 2024-12-18
2115 Transcriptional shifts and microbiome dynamics in sorghum roots during vegetative growth under drought stress
Kabir, A. H.; Brailey-Jones, P.; Abdelrahman, M.; Legeay, J.; Ahmed, B.; Tran, L.-S. P.; Bennetzen, J. L.
10.1101/2024.07.19.604343 — plant biology — Posted on 2024-12-17
2116 NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway
Magana-Avila, G. R.; Carbajal-Contreras, H.; Amnekar, R.; Dite, T.; Tellez-Sutterlin, M.; Garcia-Avila, K.; Marquina-Castillo, B.; Lopez-Saavedra, A.; Vazquez, N.; Rojas-Ortega, E.; Delpire, E.; Ellison, D. H.; Alessi, D. R.; Gamba, G.; Castaneda-Bueno, M.
10.1101/2024.12.12.628222 — physiology — Posted on 2024-12-17
2117 MCM2 mediates post-MI cardioprotection by promoting the pro-angiogenic cardiosome signaling
Alam, P.; Huang, W.; Adam, M.; Nieman, M.; Stutenroth, S.; Tranter, M.; Wang, Y.-G.; Kanisicak, O.
10.1101/2024.12.12.628232 — physiology — Posted on 2024-12-17
2118 Ice and air: Visualisation of freeze-thaw embolism and freezing spread in young L. tulipifera leaves
Johnson, K. M.; Scherer, M.; Gerber, D.; Style, R. W.; Dufresne, E. R.; Brodersen, C. R.
10.1101/2024.10.26.620221 — physiology — Posted on 2024-12-17
2120 A novel pan class-I glucose transporter inhibitor DRB18 exhibits synergistic effects in vitro and in vivo with paclitaxel against human non-small cell lung cancer
Shriwas, P.; Bachmann, L.; Ward, R.; Adhicary, S.; Nielsen, C. M.; Li, Y.; Zhang, H.; Song, J.; Roberts, D.; Bergmeier, S.; Chen, X.
10.1101/2024.12.15.628558 — cancer biology — Posted on 2024-12-17
2121 Effectiveness of FLASH vs conventional dose rate radiotherapy in a model of orthotopic, murine breast cancer
Melemenidis, S.; Viswanathan, V.; Dutt, S.; Manjappa, R.; Kapadia, N.; Lau, B.; Soto, L. A.; Ashraf, R. M.; Thakur, B.; Mutahar, A. Z. I.; Skinner, L. B.; Yu, A. S.; Surucu, M.; Casey, K. M.; Rankin, E. B.; Horst, K. C.; Graves, E. E.; Loo, B. W.; Dirbas, F. M.
10.1101/2024.12.14.628467 — cancer biology — Posted on 2024-12-17
2126 Inferring gene-pathway associations from consolidated transcriptome datasets: an interactive gene network explorer for Tetrahymena thermophila
Bertagna, M. A.; Bright, L. J.; Ye, F.; Jiang, Y.-Y.; Pradhan, A.; Sarkar, D.; Kumar, S.; Gao, S.; Turkewitz, A. P.; Tsypin, L. M.
10.1101/2024.12.12.627356 — bioinformatics — Posted on 2024-12-17
2129 Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon
Mendez-Dorantes, C.; Zeng, X.; Karlow, J. A.; Schofield, P.; Turner, S.; Kalinowski, J.; Denisko, D.; Lee, E. A.; Burns, K. H.; Zhang, C.-Z.
10.1101/2024.12.14.628481 — genomics — Posted on 2024-12-17
2130 Extrachromosomal DNA-mediated glutamine synthetase 2 (GS2) amplification enables glufosinate resistance in Amaranthus palmeri
Noguera, M. M.; Albert, P. S.; Saski, C. A.; Birchler, J. A.; Porri, A.; Meiners, I.; Lerchl, J.; Roma-Burgos, N.
10.1101/2024.12.13.628355 — genomics — Posted on 2024-12-17
2131 Aging disrupts spatiotemporal coordination in the cycling ovary
Lan, T. C. T.; Fischer, D. S.; Kochersberger, A.; Raichur, R.; Szady, S.; Simeonova, R.; Minagar, A.; Tran, H.; Shalek, A. K.; Sabeti, P.; Kumar, V.; Marrero, G.; Barrera, I.; Mangiameli, S.; Chen, F.; Garrison, J. L.; Chung, H.
10.1101/2024.12.15.628550 — genomics — Posted on 2024-12-17
2132 Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulation
Varshney, A.; Manickam, N.; Orchard, P.; Tovar, A.; Ventresca, C.; Zhang, Z.; Feng, F.; Mears, J.; Erdos, M. R.; Narisu, N.; Nishino, K.; Rai, V.; Stringham, H.; Jackson, A. U.; Tamsen, T.; Gao, C.; Yang, M.; Koues, O. I.; Welch, J. D.; Burant, C. F.; Williams, L. K.; Jenkinson, C.; DeFronzo, R. A.; Norton, L.; Saramies, J.; Lakka, T. A.; Laakso, M.; Tuomilehto, J.; Mohlke, K. L.; Kitzman, J. O.; Koistinen, H. A.; Liu, J.; Boehnke, M.; Collins, F. S.; Scott, L. J.; Parker, S. C.
10.1101/2023.12.15.571696 — genomics — Posted on 2024-12-17
2139 A complete collagen IV fluorophore knock-in toolkit reveals -chain diversity in basement membrane
Srinivasan, S.; Ramos-Lewis, W.; Morais, M. R. P. T.; Chi, Q.; Soh, A. W. J.; Williams, E.; Lennon, R.; Sherwood, D. R.
10.1101/2024.12.14.628508 — developmental biology — Posted on 2024-12-17
2142 De novo evolution of antibiotic resistance to Oct-TriA1
Chowdhury, F. R.; Mercado, L. D.; Kharitonova, K.; Findlay, B.
10.1101/2024.12.17.628969 — microbiology — Posted on 2024-12-17
2145 G protein Inactivation as a Mechanism for Addiction Treatment
Neiswanger, C.; Ruiz, M. V.; Kimball, K.; Lee, J. D.; Land, B. B.; Berndt, A.; Chavkin, C.
10.1101/2024.12.16.628727 — neuroscience — Posted on 2024-12-17
2146 Dimorphic Neural Network Architecture Prioritizes Sexual-related Behaviors in Male C.elegans
WANG, X.; LIU, H.; YANG, W.; YANG, J.; SUN, X.; LIU, Q.; ZHU, Y.; SUN, Y.; LIU, C.; SHI, G.; LIU, Q.; ZHANG, K.; DI, Z.; YANG, W.; Liu, H.
10.1101/2024.12.13.628461 — neuroscience — Posted on 2024-12-17
2147 Mechanisms of Alpha-Synuclein Seeded Aggregation in Neurons Revealed by Fluorescence Lifetime Imaging
Ivey, P.-M. E.; Sosa, M. G.; Salem, A.; Min, S.; Qi, W.; Scott, A. N.; Ejendal, K. F. K.; Kinzer-Ursem, T. L.; Rochet, J.-C.; Webb, K. J.
10.1101/2024.12.16.628520 — neuroscience — Posted on 2024-12-17
2149 Optogenetic inhibition quenches the integration of sensory input in the cortex
Ambrosone, M.; Montagni, E.; Resta, F.; Curti, L.; Mannaioni, G.; Masi, A.; Pavone, F. S.; Allegra Mascaro, A. L.
10.1101/2024.12.12.628207 — neuroscience — Posted on 2024-12-17
2150 Reduced enteric BDNF-TrkB signaling drives glucocorticoid-mediated GI dysmotility
Slosberg, J. S.; Puttapaka, S.; Seika, P.; Hong, S. M.; Singh, A.; Kulkarni, S.
10.1101/2024.12.13.628260 — neuroscience — Posted on 2024-12-17
2152 Psilocybin causes sex, time, and dose dependent alterations in brain signaling pathways
Barnett, J. H.; Todd, K. T.; Benetatos, J.; Rabichow, B. E.; Gibson, K. A.; Olney, K. C.; Fryer, J. D.
10.1101/2024.12.16.628764 — neuroscience — Posted on 2024-12-17
2153 A low-cost FPGA-based approach for pile-up corrected high-speed in vivo FLIM imaging
Moros, F. V.; Amiet, D.; Meister, R. M.; von Faber-Castell, A.; Wyss, M. T.; Saab, A. S.; Zbinden, P.; Weber, B.; Ravotto, L.
10.1101/2024.12.17.628898 — neuroscience — Posted on 2024-12-17
2156 Visual and vestibular processing of vertical motion: a psychophysical study
Delle Monache, S.; La Scaleia, B.; Finazzi Agro, A.; Lacquaniti, F.; Zago, M.
10.1101/2024.12.15.628168 — neuroscience — Posted on 2024-12-17
2159 A deep learning framework for automated and generalized synaptic event analysis
O'Neill, P. S.; Baccino-Calace, M.; Rupprecht, P.; Lee, S.; Hao, Y. A.; Lin, M.; Friedrich, R. W.; Mueller, M.; Delvendahl, I.
10.1101/2023.11.02.565316 — neuroscience — Posted on 2024-12-17
2162 Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles
Moodie, J. E.; Buchanan, C. R.; Furtjes, A.; Conole, E. L. S.; Stolicyn, A.; Corley, J.; Ferguson, K.; Hernandez, M. V.; Maniega, S. M.; Russ, T. C.; Luciano, M. C.; Whalley, H. C.; Bastin, M. E.; Wardlaw, J.; Deary, I.; Cox, S. R.
10.1101/2024.12.17.628670 — neuroscience — Posted on 2024-12-17
2166 Kinetic-model-guided engineering of multiple S. cerevisiae strains improves p-coumaric acid production
Narayanan, B.; Jiang, W.; Wang, S.; Saez-Saez, J.; Weilandt, D. R.; Masid, M.; Hesselberg-Thomsen, V.; Borodina, I.; Hatzimanikatis, V.; Miskovic, L.
10.1101/2024.12.15.628543 — systems biology — Posted on 2024-12-17
2167 Leaf size determines damage- and herbivore-induced volatile emissions in maize
Waterman, J. M.; Cofer, T. M.; von Laue, O. M.; Mateo, P.; Wang, L.; Erb, M.
10.1101/2024.11.14.623649 — plant biology — Posted on 2024-12-17
2168 Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers Apolipoprotein B Containing Lipoproteins in Mice
Helsley, R. N.; Zelows, M.; Noffsinger, V. P.; Anspach, G. B.; Dharanipragada, N.; Mead, A. E.; Cobo, I.; Carter, A.; Wu, Q.; Shalaurova, I.; Saito, K.; Morganti, J. M.; Gordon, S. M.; Graf, G. A.
10.1101/2024.12.13.628437 — physiology — Posted on 2024-12-17
2170 Deep Learning-Driven Subtype Classification of Colorectal Cancer Using Histopathology Images for Personalized Medicine
Truong Le, T.; Fortune Mavuso, M.; Nguyen Thien Dao, P.; Ngoc Anh Nguyen, H.; Thuy Mai, T.; Thi Quang, K.
10.1101/2024.12.12.628270 — cancer biology — Posted on 2024-12-17
2171 Eosinophils restrict CRC metastasis by inhibiting pro-tumorigenic SPP1+ macrophage differentiation
Handler, K.; Raju, D.; Gurtner, A.; Dalessi, T.; Brugger, M. D.; Crepaz, D.; Esposito, C.; Trajanoski, Z.; Muenz, C.; Scharl, M.; Valenta, T.; Piscuoglio, S.; Fazilaty, H.; Arnold, I. C.
10.1101/2024.12.13.628333 — cancer biology — Posted on 2024-12-17
2172 The oncometabolite D-2-hydroxyglutarate promotes DNA hypermethylation at lineage-specific enhancers controlling microglial activation in IDHmut gliomas
Laurenge, A.; Pugliese, P.; Richard, Q.; Mathon, B.; Jouannet, S.; Hayat, Y.; Scuderi, S.; Marijon, P.; Labreche, K.; Alentorn, A.; Verreault, M.; Idbaih, A.; Birzu, C.; Huillard, E.; Pottier, N.; Desmons, A.; Fayache, I.; Kaas, G. A.; Kingsley, P. J.; Marnett, L. J.; Duplus, E.; El-Habr, E.; Salas, L. A.; Mokhtari, K.; Tran, S.; Touat, M.; Bielle, F.; Suva, M. L.; Iavarone, A.; Ceccarelli, M.; Mallat, M.; Sanson, M.; Castro-Vega, L. J.
10.1101/2024.08.23.608811 — cancer biology — Posted on 2024-12-17
2174 Mechanical force regulates the inhibitory function of PD-1
Chen, H.; Zhang, Y.; Cui, L.; Fan, J.; Wu, S.; Zhou, H.; Zhang, Y.; Song, G.; Jiang, N.; Zhu, M.; Lou, C.; Chen, W.; Lou, J.
10.1101/2024.12.13.628463 — biophysics — Posted on 2024-12-17
2177 dsRNAmax: a Multi-Target Chimeric dsRNA Designer for Safe And Effective Crop Protection
Fletcher, S. J.; Lawrence, J.; Sawyer, A.; Manzie, N.; Gardiner, D. M.; Mitter, N.; Brosnan, C. A.
10.1101/2024.12.15.628581 — bioinformatics — Posted on 2024-12-17
2178 Prediction of peptide structural conformations with AlphaFold2
Ille, A. M.; Markosian, C.; Burley, S. K.; Pasqualini, R.; Arap, W.
10.1101/2024.12.03.626727 — bioinformatics — Posted on 2024-12-17
2179 Lit-OTAR Framework for Extracting Biological Evidences from Literature
Tirunagari, S.; Saha, S.; Venkatesan, A.; Suveges, D.; Buniello, A.; Ochoa, D.; McEntyre, J.; McDonagh, E.; Harrison, M.
10.1101/2024.03.06.583722 — bioinformatics — Posted on 2024-12-17
2181 Unravelling traits with complex inheritance mode: a gene panel perspective
Szyda, J.; Suchocki, T.; Golab, M.; Budny, B.; Mielczarek, M.; Liu, J.; Kotlarz, K.; Wrotkowska, E.; Ruchala, M.; Ziemnicka, K.
10.1101/2024.12.14.628476 — bioinformatics — Posted on 2024-12-17
2182 StayRose: a photostable StayGold derivative red-shifted by genetic code expansion
Scott, W.; Ivorra-Molla, E.; Akhuli, D.; Massam-Wu, T.; Cook, J.; Song, L.; Mishima, M.; Crow, A.; Balasubramanian, M. K.
10.1101/2024.12.13.628370 — bioengineering — Posted on 2024-12-17
2183 Molecular insights into the effect of hexanediol on FUS phase separation
Zheng, T.; Wake, N.; Weng, S.-L.; Perdikari, T. M.; Murthy, A. C.; Mittal, J.; Fawzi, N. L.
10.1101/2022.05.05.490812 — biochemistry — Posted on 2024-12-17
2186 Material matters: raw material influences stone tool performance in capuchin monkeys
O'Malley, T. D. R.; Reeves, J. S.; Slania, N. E.; Falotico, T.; Proffitt, T.; de la Torre, I.; Luncz, L. V.
10.1101/2024.12.12.628091 — animal behavior and cognition — Posted on 2024-12-17
2190 RARE HABITATS, RARE SPECIES, AND INVASIVE PREDATORS HIGHLIGHT MANAGEMENT COMPLEXITIES IN THE COLORADO RIVER SYSTEM
Hossack, B. R.; Stemp, K. M.; Goldberg, C. S.; Duke, A. C. K.; Preston, T. N.; Arnold, J. L.; Ray, A. M.
10.1101/2024.12.15.628570 — ecology — Posted on 2024-12-17
2194 Modelling co-development between somites and neural tube with human Trunk-like Structures (hTLS)
Makwana, K.; Tilley, L.; Chakravarty, P.; Thompson, J.; Baillie-Benson, P.; Rodriguez-Polo, I.; Moris, N.
10.1101/2024.12.16.628661 — developmental biology — Posted on 2024-12-17
2198 In vivo properties of Arabidopsis FCA condensates involved in RNA 3' processing
Jang, G.-J.; Payne-Dwyer, A. L.; Maple, R.; Wu, Z.; Liu, F.; Lopez, S. G.; Wang, Y.; Fang, X.; Leake, M. C.; Dean, C.
10.1101/2024.04.06.588283 — molecular biology — Posted on 2024-12-17
2200 Eukaryotic composition across seasons and social groups in the gut microbiota of wild baboons
Chege, M.; Feretti, P.; Webb, S.; Macharia, R. W.; Obiero, G.; Kamau, J.; Alberts, S. C.; Tung, J.; Akinyi, M. Y.; Archie, E.
10.1101/2024.12.17.628920 — microbiology — Posted on 2024-12-17
2201 A bacterial NLR-related protein recognizes multiple unrelated phage triggers to sense infection
Kibby, E. M.; Robbins, L. K.; Deep, A.; Min, N. K.; Whalen, L. A.; Nagy, T. A.; Freeborn, L.; Corbett, K. D.; Whiteley, A. T.
10.1101/2024.12.17.629029 — microbiology — Posted on 2024-12-17
2202 Sepsis induces long-term reprogramming of human HSPCs and drives myeloid dysregulation in sepsis survivors
De Zuani, M.; Laznickova, P.; Hortova Kohoutkova, M.; Bosakova, V.; Andrejcinova, I.; Vadovicova, N.; Tomaskova, V.; Mytnikova, A.; Stichova, J.; Tomas, T.; Hrdy, J.; Borakova, K.; Uldrijan, S.; Vlkova, M.; Sramek, V.; Helan, M.; Bendickova, K.; Fric, J.
10.1101/2024.12.14.628447 — immunology — Posted on 2024-12-17
2203 Implications of diabetes mellitus on pathophysiology of Tuberculosis: Role of AGE-RAGE Axis and Glycated Proteins
Panda, S.; Singh, A.; Seelan, D. M.; Arora, A.; Dagar, G.; Ethayathulla, A. S. A.; Luthra, P. K.; Mohan, A.; Vikram, N. K.; Gupta, N. K.; Singh, M.; Singh, A.
10.1101/2024.12.15.628594 — immunology — Posted on 2024-12-17
2204 What makes human cortical pyramidal neurons functionally complex
Aizenbud, I.; Yoeli, D.; Beniaguev, D.; de Kock, C. P.; London, M.; Segev, I.
10.1101/2024.12.17.628883 — neuroscience — Posted on 2024-12-17
2209 Multi-omic characterization of human sural nerves acrosspolyneuropathies
Heming, M.; Wolbert, J.; Boersch, A.-L.; Thomas, C.; Mausberg, A. K.; Lu, I.-N.; Tietz, J.; Dienhart, F.; Dambietz, C.; Muether, M.; Uerschels, A.-K.; Keyvani, K.; Szepanowski, F.; Eggert, B.; Liebig, K. C.; Doppler, K.; Ueceyler, N.; Aprea, J.; Dahl, A.; Stassart, R.; Fledrich, R.; Wiendl, H.; Sommer, C.; Stettner, M.; Meyer zu Hoerste, G.
10.1101/2024.12.05.627043 — neuroscience — Posted on 2024-12-17
2211 Synchronous 3D patterning of diverse CNS progenitors generates motor neurons of broad axial identity
Buchner, F.; Dokuzluoglu, Z.; Thomas, J.; Caldarelli, A.; Kavali, S.; Grass, T.; Rost, F.; Rodriguez-Muela, N.
10.1101/2024.12.13.628384 — neuroscience — Posted on 2024-12-17
2213 Neuroimmune mechanisms of a mouse model of chronic back pain
Goins, A. E.; Zurek, N. A.; Holguin, C.; Gravelle, A.; Goyal, S.; Noor, S.; Demeter, J. B.; Koch, M. R.; de la Pena, J. B.; Westlund, K. N.; Alles, S. R. A.
10.1101/2024.12.13.628454 — neuroscience — Posted on 2024-12-17
2218 Instantaneous Frequency: A New Functional Biomarker for Dynamic Brain Causal Networks
Tang, H.; Dai, S.; Guo, L.; Gu, P.; Liu, G.; Leow, A. D.; Thompson, P. M.; Huang, H.; Zhan, L.
10.1101/2024.12.17.628965 — neuroscience — Posted on 2024-12-17
2219 cfos principal cells and interneurons are strongly reactivated by sharp wave ripples
Javed, M. H.; Robles-Hernandez, E. M.; Patel, R.; Haberl, M. G.; da Silva, S. V.
10.1101/2024.12.17.628897 — neuroscience — Posted on 2024-12-17
2222 Diminished functional gradient of the precuneus during altered states of consciousness
Lyu, D.; Adapa, R.; Carhart-Harris, R. L.; Roseman, L.; Owen, A. M.; Naci, L.; Menon, D. K.; Stamatakis, E. A.
10.1101/2024.12.17.628862 — neuroscience — Posted on 2024-12-17
2224 Adaptation to cystine limitation stress promotes PDAC tumor growth and metastasis through translational upregulation of OxPPP
Li, Y.; Li, Z.; Sun, D.; Ni, B.; Tan, M.; Shay, A.; Wang, M.; Meng, C.; Shen, G.; Fu, B.; Shan, Y.; Zhou, T.; Xie, Y.; Chen, K.-M.; Qiao, B.; Dang, Y.; Kimball, S. R.; Singh, P. K.; Wang, X.; Hao, J.; Yang, S.
10.1101/2024.12.12.628246 — cancer biology — Posted on 2024-12-17
2226 The CCL17-CCR4 axis is critical for mutant STAT6-mediated microenvironmental remodelling and therapeutic resistance in Relapsed/Refractory Diffuse Large B Cell Lymphoma
Abraham, M. J.; Guilbert, C.; Gagnon, N.; Goncalves, C.; Benoit, A.; Rys, R. N.; Preston, S. E. J.; Morin, R. D.; Miller, W. H.; Johnson, N. A.; del Rincon, S. V.; Mann, K. K.
10.1101/2024.12.13.628396 — cancer biology — Posted on 2024-12-17
2227 Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma
Seidel, K.; Piscol, R.; Nguyen, T. T. T.; Shelton, A.; Cottonham, C.; de la Cruz, C. C.; Castillo, J.; Garcia, J.; Segal, E.; Merchant, M.; Yang, Y. A.; Chen, J.; Ahmed, M.; Scherl, A.; Vij, R.; Mosteiro, L.; Wu, Y.; Modrusan, Z.; Metcalfe, C.; Siebel, C. W.
10.1101/2024.12.13.628320 — cancer biology — Posted on 2024-12-17
2228 Small molecule targeting of FBXO21 mediated p85αubiquitylation in acute myeloid leukemia
Dobish, K. K.; Vishwakarma, S.; Peters, H. C.; Winship, C. B.; Alvarado, D.; Hyde, R. K.; Natarajan, A.; Buckley, S. M.
10.1101/2024.12.13.628427 — cancer biology — Posted on 2024-12-17
2229 High-Throughput Targeted Drug Screening for NF1-associated High-Grade Gliomas with ATRX Deficiency
Dubey, S.; Rai, S.; Guillen, F.; Iyer, A.; Aung, S.; Yuan, M.; Eberhart, C. G.; Rodriguez, F. J.
10.1101/2024.12.14.628525 — cancer biology — Posted on 2024-12-17
2231 PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis
Su, H.; Sun, Y.; Guo, H.; Sun, C.-w.; Chen, Q.; Liu, S.; Li, A.; Gao, M.; Zhao, R.; Raffel, G.; Jin, J.; Qu, C.-K.; Yu, M.; Klug, C. A.; Zheng, Y. G.; Ballinger, S.; Kutny, M.; Long Zheng, X.; Chong, Z.; Senevirathne, C.; Gross, S.; Chen, Y.; Luo, M.; Zhao, X.
10.1101/2024.12.12.628174 — cancer biology — Posted on 2024-12-17
2232 Anti-inflammatory assessment of zinc oxide nanoparticles mediated Aframomum citratum (C. Pereira) K. Schum (Zingiberaceae) in Wistar rats
Eya'ane Meva, F.; Nga Essama, D. M.; Nguemfo, E. L.; Bamal, H.-D.; Ntoumba, A. A.; Belle Ebanda Kedi, P.; Beglau, T. H. Y.; Tako Djimefo, A. K.; Djuidje, A. G.; Chimi Tchatchouang, G.; Nanga, C. C.; Fonye Nyuyfoni, G.; Tchangou Njimou, A. F.; Evouna, M. I. D.; Mintang Fongang, A. U.; Janiak, C.
10.1101/2024.12.15.628600 — pharmacology and toxicology — Posted on 2024-12-17
2233 A three-dimensional ex vivo model recapitulates in vivo features and unravels increased drug resistance in childhood acute lymphoblastic leukemia
Kanari, M.; Jimenez Garcia, I.; Steffen, F.; Krattiger, L. A.; Bataclan, C.; Liu, W.; Simona, B.; Deplancke, B.; Naveiras, O.; Ehrbar, M.; Bornhauser, B.; Bourquin, J.-P.
10.1101/2024.12.13.628110 — cancer biology — Posted on 2024-12-17
2234 The CoREST complex inhibitor, corin, leads to decreased tumor growth, increased cellular differentiation and extended lifespan in atypical teratoid rhabdoid tumor xenograft models
Geethadevi, A.; Vaidya, N.; Fisher, R. J.; Findlay, T.; Deng, Y.; Pham, K.; Kumar, V.; Beck, S.; Lucas, C.-H. G.; Eberhart, C. G.; Xu, J.; Cole, P. A.; Rubens, J.; Collard, M.; Raabe, E. H.; Alani, R. M.
10.1101/2024.12.14.628381 — cancer biology — Posted on 2024-12-17
2237 Diverse Intracellular Trafficking of Insulin Analogs byMachine Learning-based Colocalization and DiffusionAnalysis
Bleshoy, S. V.; Kaestel-Hansen, J.; Nielsen, A. J.; Mishra, N. K.; Jensen, K. J.; Hatzakis, N. S.
10.1101/2024.12.12.628100 — biophysics — Posted on 2024-12-17
2242 AmpliPiper: A versatile amplicon-seq analysis tool for multilocus DNA barcoding
Bertelli, A.; Steindl, S.; Kirchner, S.; Schwahofer, P.; Haring, E.; Szucsich, N.; Kruckenhauser, L.; Kapun, M.
10.1101/2024.12.11.628038 — bioinformatics — Posted on 2024-12-17
2245 Comparison of imaging-based single-cell resolution spatial transcriptomics profiling platforms using formalin-fixed, paraffin-embedded tumor samples
Ozirmak Lermi, N.; Molina Ayala, M.; Hernandez, S.; Lu, W.; Khan, K.; Serrano, A.; Lubo, I.; Hamana, L.; Tomczak, K.; Barnes, S.; Dou, J.; Liang, Q.; Team, R.; Raso, M. G.; Tang, X.; Jiang, M.; Sanchez-Espiridion, B.; Weissferdt, A.; Heymach, J.; Zhang, J.; Sepesi, B.; Cascone, T.; Tsao, A.; Altan, M.; Mehran, R.; Gibbons, D.; Wistuba, I.; Haymaker, C.; Chen, K.; Solis Soto, L. M.
10.1101/2024.12.13.628390 — bioinformatics — Posted on 2024-12-17
2246 miRScore: a rapid and precise microRNA validation tool
Vanek, A.; Griffiths-Jones, S. J.; Meyers, B. C.; Shahid, S.; Axtell, M. J.
10.1101/2024.12.12.628184 — bioinformatics — Posted on 2024-12-17
2248 Echidna: A Bayesian framework for quantifying gene dosage effect impacting phenotypic plasticity
Fan, J. L.; Zhang, M.; O'Brien, W. G.; Myers, J. D.; Melms, J. C.; Biermann, J.; D'Souza, E.; Tagore, S.; Beltran-Velez, N.; Hoffer-Hawlik, K.; Preau, A.; Arora, I.; Chatterjee, S.; Izar, B.; Azizi, E.
10.1101/2024.12.15.628568 — bioinformatics — Posted on 2024-12-17
2250 A real-time forecasting framework for emerging infectious diseases affecting animal populations
Theng, M.; Baker, C. M.; Lee, S.; Breed, A.; Roche, S.; Sellens, E.; Fraser, C.; Wood, K.; Jewell, C. P.; Stevenson, M. A.; Firestone, S.
10.1101/2024.12.12.628251 — bioinformatics — Posted on 2024-12-17
2255 High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy
Guan, H.; Chen, J.; Kaur, K.; Amreen, B.; Lesseur, C.; Dolios, G.; Andra, S.; Narasimhan, S.; Pulivarthi, D.; Midya, V.; De Witte, L. D.; Bergink, V.; Rommel, A. S.; Petrick, L.
10.1101/2024.12.16.628663 — bioinformatics — Posted on 2024-12-17
2256 Flexible and robust cell type annotation for highly multiplexed tissue images
Sun, H.; Yu, S.; Casals, A. M.; Bäckström, A.; Lu, Y.; Lindskog, C.; Ruffalo, M.; Lundberg, E.; Murphy, R. F.
10.1101/2024.09.12.612510 — bioinformatics — Posted on 2024-12-17
2257 iModMix: Integrative Module Analysis for Multi-omics Data
Narvaez-Bandera, I. Y.; Lui, A.; Mekonnen, Y. A.; Rubio, V.; Sulman, N.; Wilson, C. M.; Ackerman, H.; Ospina, O.; Gonzalez-Calderon, G.; Flores, E.; Li, Q.; Chen, Y. A.; Fridley, B.; Stewart, P. A.
10.1101/2024.11.12.623208 — bioinformatics — Posted on 2024-12-17
2261 A Wearable Spiral Ultrasound Patch for Focused Ultrasound Peripheral Neuromodulation of Diabetic Neuropathic Pain
Pu, C.; Fu, B.; Lu, P.; Guan, X.; Zhang, J.; Shen, Y.; Li, X.; Guo, L.; Xu, H.; Jiang, X.; Peng, C.
10.1101/2024.12.12.628265 — bioengineering — Posted on 2024-12-17
2263 Magellanic penguins balance navigation with foraging opportunities in complex current regimes
Gunner, R. M.; Quintana, F.; Tonini, M. H.; Holton, M. D.; Yoda, K.; Crofoot, M. C.; Wilson, R. P.
10.1101/2024.12.12.628121 — animal behavior and cognition — Posted on 2024-12-17
2265 Postural control in an upright snake
Hoffmann, L. A.; Bryde, P.; Davenport, I. C.; Ganga Prasath, S.; Jayne, B. C.; Mahadevan, L.
10.1101/2024.12.13.628369 — animal behavior and cognition — Posted on 2024-12-17
2270 Thermal selection shifts genetic diversity and performance in blue mussel juveniles
Nascimento-Schulze, J. C.; Vajedsamiei, J.; Bean, T. P.; Frankholz, L.; Brennan, R. S.; Melzner, F.; Ellis, R. P.
10.1101/2024.12.12.628131 — genomics — Posted on 2024-12-17
2271 Epigenomics of embryogenesis in turbot (Scophthalmus maximus)
Aramburu, O.; Pardo, B. G.; Jimenez-Gonzalez, A.; Blanco-Hortas, A.; Macqueen, D.; Bouza, C.; Martinez, P.
10.1101/2024.12.12.628162 — genomics — Posted on 2024-12-17
2272 Collective dynamics of DNA methylation during ageing
Hashtroud, A.; Bonder, M. J.; Stegle, O.; von Meyenn, F.; Reik, W.; Rulands, S.
10.1101/2024.12.15.628564 — genomics — Posted on 2024-12-17
2273 Evaluating the role of pre-training dataset size and diversity on single-cell foundation model performance
DenAdel, A.; Hughes, M.; Thoutam, A.; Gupta, A.; Navia, A. W.; Fusi, N.; Raghavan, S.; Winter, P. S.; Amini, A. P.; Crawford, L.
10.1101/2024.12.13.628448 — genomics — Posted on 2024-12-17
2274 Characterization of both major histocompatibility complex classes in a wild social mammal: the banded mongoose
Schubert, N.; Nichols, H. J.; Mwanguhya, F.; Businge, R.; Kyambulima, S.; Mwesige, K.; Cant, M. A.; Winternitz, J. C.
10.1101/2024.12.14.628504 — genetics — Posted on 2024-12-17
2277 Assessing group size and the demographic composition of unhabituated northern muriqui (Brachyteles hypoxanthus) using non-invasive biomonitoring
Kaizer, M. C.; Sales, N. G.; Alvim, T. H. G.; Strier, K. B.; de Melo, F. R.; Boubli, J. P.; Young, R. J.; McDevitt, A. D.
10.1101/2024.12.13.628264 — ecology — Posted on 2024-12-17
2278 Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy
Penna, V. R.; Amrute, J. M.; Engel, M.; Shiel, E. A.; Farra, W.; Cannon, E. N.; Leu-Turner, C.; Ma, P.; Villanueva, A.; Shin, H.; Parvathaneni, A.; Jager, J.; Bueno-Beti, C.; Asimaki, A.; Lavine, K.; Saffitz, J.; Chelko, S. P.
10.1101/2024.12.11.628020 — immunology — Posted on 2024-12-17
2283 Preclinical Proof of Concept for SNAPTM-TIL: a personalized, next-generation tumor-infiltrating lymphocyte therapy platform
Halder, T. G.; Kelley, E.; Soria-Bustos, J.; Thode, T.; NG, S.; Bargenquast, T.; Weston, A.; Rodriguez del Villar, R.; Kaadige, M.; Borazanci, E.; Gordon, M.; Moser, J.; Tsai, F.; Priceman, S. J.; Forman, S. J.; Xing, Y.; Altin, J.; Soldi, R.; Sharma, S.
10.1101/2024.12.12.628191 — immunology — Posted on 2024-12-17
2285 Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy chain locus
Gornitzka, M. B.; Rosjo, E.; Jana, U.; Ford, E. E.; Tourancheau, A.; Lees, W. D.; Vanwinkle, Z.; Smith, M. L.; Watson, C. T.; Lossius, A.
10.1101/2024.12.14.628445 — immunology — Posted on 2024-12-17
2290 Pre-oviposition development of the brown anole (Anolis sagrei)
Weberling, A.; Shylo, N. A.; Kircher, B. K.; Wilson, H.; McClain, M.; Marchini, M.; Starr, K.; Sanger, T. J.; Hollfelder, F.; Trainor, P.
10.1101/2024.12.15.628549 — developmental biology — Posted on 2024-12-17
2294 Cerebral Venous Blood Flow Regulates Brain Fluid Clearance via Dural Lymphatics
El Kamouh, M.-R.; Spajer, M.; Singhabahu, R.; Sailor, K. A.; Bourrienne, M.-C.; Mouton, L.; Koundal, S.; Doukhi, D.; Grine, A.; Ninnemann, J.; Nasri, A.; Joly Marolany, A.-L.; Akbar, D.; Gottschalk, J.; Ruze, A.; Buscher, E.; Langui, D.; Van Wassenhove, J.; Mazighi, M.; Eichmann, A.; Lledo, P.-M.; Benveniste, H.; Santin, M. D.; Lehericy, S.; Thomas, J.-L.; Lenck, S.
10.1101/2024.12.12.628127 — neuroscience — Posted on 2024-12-17
2295 A novel isoform of Tensin1 promotes actin filament assembly for efficient erythroblast enucleation
Coffin, M.; Fowler, V. M.; Ghosh, A.; Diaz, D. M.; Barndt, S.; Schulz, V.; Gallagher, P.; Lo, S. H.
10.1101/2024.12.13.628322 — cell biology — Posted on 2024-12-17
2298 Functional fingerprinting for the developing brain using deep metric learning: an ABCD study
Xu, R.; Zhao, S.; Jin, Q.; Wang, Z.; Zhao, K.; Zhong, S.; Zhang, J.; Liu, Y.; Qi, T.; Wei, Y.
10.1101/2024.12.13.628288 — neuroscience — Posted on 2024-12-17
2299 Insular cortex encodes task alignment
Niediek, J.; Jankowski, M. M.; Polterovich, A.; Kazakov, A.; Nelken, I.
10.1101/2024.12.13.628250 — neuroscience — Posted on 2024-12-17
2300 Control of odor sensation by light and cryptochrome in the Drosophila antenna
Thakur, D.; Hunt, S.; Tsou, T.; Petty, M.; Rodriguez, J. M.; Montell, C.
10.1101/2024.12.12.628259 — neuroscience — Posted on 2024-12-17
2301 The selfish yet forgetful brain: Stable cerebral oxygen metabolism during hypoglycemia but impaired memory consolidation
Bose, A.; Haschka, S. J.; Koehler, J.; Hesse, F.; Martin, S.; Steinberg, L.; Iakoubov, R.; Riedl, V.
10.1101/2024.12.12.628178 — neuroscience — Posted on 2024-12-17
2304 A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs
Godschall, E. N.; Gungul, T. B.; Sajonia, I. R.; Buyukaksakal, A. K.; Ogilvie, S.; Keeler, A. B.; Zhang, Y.; Deutsch, T. C. J.; Shi, Y.; Conley, N. J.; Webster, A. N.; Calhan, O. Y.; Akkoub, A.; Malik, K.; West, K. I.; Karthikeyan, A.; van Gerven, G.; Patel, M. K.; Campbell, J. N.; Deppmann, C. D.; Guler, A. D.
10.1101/2024.12.12.628169 — neuroscience — Posted on 2024-12-17
2305 Chronic Behavioral and Seizure Outcomes following Experimental Traumatic Brain Injury and Comorbid Klebsiella pneumoniae Lung Infection in Mice
Rewell, S. S.; Shad, A.; Chen, L.; Chu, E.; Wang, J.; Chen, K.; O'Brien, T. J.; Li, J.; Casillas-Espinosa, P. M.; Semple, B. D.
10.1101/2024.12.13.628278 — neuroscience — Posted on 2024-12-17
2308 Repeated head-exposures to a 5G-3.5 GHz signal do not alter behavior but modify intracerebral gene expression in adult male mice.
Lameth, J.; Royer, J.; Martin, A.; Marie, C.; Arnaud-Cormos, D.; Leveque, P.; Poirier, R.; Edeline, J.-M.; Mallat, M.
10.1101/2024.12.13.628345 — neuroscience — Posted on 2024-12-17
2311 In vivo human neurite exchange imaging (NEXI) at 500 mT/m diffusion gradients
Chan, K.-S.; Ma, Y.; Lee, H.; Marques, J. P.; Olesen, J. L.; Coelho, S.; Novikov, D. S.; Jespersen, S. N.; Huang, S. Y.; Lee, H.-H.
10.1101/2024.12.13.628450 — neuroscience — Posted on 2024-12-17
2312 CDNF rescues human iPSCs-derived dopamine neurons through direct binding to unfolded protein response sensors PERK and IRE1α
Kovaleva, V.; Shpironok, O.; Yu, L.-Y.; Ivanova, L.; Fudo, S.; Happonen, L.; Toots, U.; Ustav, M.; Kajander, T.; Karelson, M.; Saarma, M.
10.1101/2024.12.17.628889 — neuroscience — Posted on 2024-12-17
2313 Evidence for white matter intrinsic connectivity networks at rest and during a task: a large-scale study and templates
Itkyal, V. S.; Iraji, A.; Jensen, K.; LaGrow, T.; Duda, M.; Turner, J.; Liu, J.; Wu, L.; Du, Y.; Fries, J.; Fu, Z.; Kochunov, P.; Belger, A.; Ford, J.; Mathalon, D.; Pearlson, G.; Potkin, S. G.; Preda, A.; van Erp, T. G. M.; Yang, K.; Sawa, A.; Hutchison, K.; Osuch, E.; Theberge, J.; Abbott, C.; Mueller, B. A.; Chen, J.; Sui, J.; Adali, T.; Calhoun, V. D.
10.1101/2024.12.16.628798 — neuroscience — Posted on 2024-12-17
2314 Individual Alpha Frequency Predicts the Sensitivity of Time Perception
Morrow, A.; Wilson, M.; Geller-Montague, M.; Soldano, S.; Hajidamji, S.; Samaha, J.
10.1101/2024.12.16.628734 — neuroscience — Posted on 2024-12-17
2315 Astrocytic Signatures in Neuronal Activity: A Machine Learning-Based Identification Approach
Pirola, J. P.; DeForest, P.; Protachevicz, P. R.; Fontenas, L.; Ferreira, R. F.; Pena, R. F.
10.1101/2024.12.16.628802 — neuroscience — Posted on 2024-12-17
2316 Lysine deacetylation inhibition reverses TDP-43 mislocalization and in combination with arimoclomol ameliorates neuromuscular pathology
Scozzari, S.; Columbro, S. F.; Favagrossa, M.; Tortarolo, M.; Cagnotto, A.; Salmona, M.; De Marco, G.; Bendotti, C.; Calvo, A.; Pasetto, L.; Bonetto, V.
10.1101/2024.12.15.628528 — neuroscience — Posted on 2024-12-17
2320 Neuronal expression of E2F4DN restores adult neurogenesis in homozygous 5xFAD mice via TrkB signaling
Lozano-Urena, A.; Llabres-Mas, A. M.; Ramon-Landreau, M.; Fraj-Cebrian, A.; Sanchez-Puelles, C.; Garrido-Garcia, A.; Cano-Daganzo, V.; Valdes-Lora, L.; Frade, J. M.
10.1101/2024.12.17.628978 — neuroscience — Posted on 2024-12-17
2321 Rapid long-range synaptic remodeling in hyperacute ischemic stroke
Chen, H.; Wei, Y.; Ruje, L.; Wan, Q.; Spivakov, M.; Glebov, O. O.
10.1101/2024.12.12.628225 — neuroscience — Posted on 2024-12-17
2323 Molecular and spatial analysis of ganglion cells on retinal flatmounts: diversity, topography, and perivascularity
Tsai, N. Y.; Nimkar, K.; Zhao, M.; Lum, M. R.; Yi, Y.; Garrett, T. R.; Wang, Y.; Toma, K.; Caval-Holme, F.; Reddy, N.; Ehrlich, A. T.; Kriegstein, A. R.; Do, M. T. H.; Sivyer, B.; Shekhar, K.; Duan, X.
10.1101/2024.12.15.628587 — neuroscience — Posted on 2024-12-17
2329 Fast FEM-based Electric Field Calculations for Transcranial Magnetic Stimulation
Cao, F.; Madsen, K. H.; Worbs, T.; Puonti, O.; Siebner, H. R.; Schmitgen, A.; Kunz, P.; Thielscher, A.
10.1101/2024.12.13.628139 — neuroscience — Posted on 2024-12-17
2331 Na+/Ca2+ exchanger triggers transient disruption of axon initial segments in hippocampal granule cells after brief ischemia.
Serra, C.; Martinez-Alonso, E.; Padmashri, R.; Ayuso, M. I.; Rama, S.; Henneberger, C.; Alcazar, A.; Rusakov, D.; Scott, R.
10.1101/2024.12.13.628404 — neuroscience — Posted on 2024-12-17
2332 PinkyCaMP a mScarlet-based calcium sensor with exceptional brightness, photostability, and multiplexing capabilities
Fink, R.; Imai, S.; Gockel, N.; Lauer, G.; Renken, K.; Wietek, J.; Lamothe-Molina, P. J.; Furhmann, F.; Mittag, M.; Ziebarth, T.; Canziani, A.; Kubitschke, M.; Kistmacher, V.; Kretschmer, A.; Sebastian, E.; Schmitz, D.; Terai, T.; Gruendemann, J.; Hassan, S.; Patriarchi, T.; Reiner, A.; Fuhrmann, M.; Campbell, R. E.; Masseck, O. A.
10.1101/2024.12.16.628673 — neuroscience — Posted on 2024-12-17
2334 Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells
Blaszczyk, G. J.; Mohammadnia, A.; Piscopo, V. E. C.; Sirois, J.; Cui, Q.-L.; Yaqubi, M.; Durcan, T. M.; Schneider, R.; Antel, J.
10.1101/2024.12.17.628958 — neuroscience — Posted on 2024-12-17
2337 Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson's disease
Villette, R.; Ortis Sunyer, J.; Novikova, P.; Aho, V. T. E.; Petrov, V.; Hickl, O.; Bhanu Busi, S.; De Rudder, C.; Kunath, B. J.; Heintz-Buschart, A.; Trezzi, J.-P.; Halder, R.; Jaeger, C.; Lebrun, L. E.; Daujeumont, A.; Schade, S.; Janzen, A. E.; Jehmlich, N.; von Bergen, M.; Laczny, C. C.; May, P.; Trenkwalder, C.; Oertel, W.; Mollenhauer, B.; Wilmes, P.
10.1101/2024.12.13.628341 — systems biology — Posted on 2024-12-17
2342 Cannabinoid agonist WIN55,212-2 prevents scopolamine-induced impairment of spatial memory
Moreno-Rodriguez, M.; Bengoetxea de Tena, I.; Martinez-Gardeazabal, J.; Pereira-Castelo, G.; Llorente-Ovejero, A.; Manuel, I.; Rodriguez-Puertas, R.
10.1101/2024.12.12.628159 — pharmacology and toxicology — Posted on 2024-12-17
2343 Phthalates Impair Estrogenic Regulation of HIF2α and Extracellular Vesicle Secretion by Human Endometrial Stromal Cells
Beal, J. R.; Bhurke, A.; Carlson, K. E.; Katzenellenbogen, J.; Yu, J.; Flaws, J.; Bagchi, I. C.; Bagchi, M. K.
10.1101/2024.12.12.628185 — pharmacology and toxicology — Posted on 2024-12-17
2344 Cylicodiscus gabunensis (FABACEAE) aqueous stem bark extract mediated silver nanoparticle enhance anti-inflammation on Wistar rats
Eya'ane Meva, F.; Nguadie Mponge, P.; Koube, J.; Fonye Nyuyfoni, G.; Hzounda Fokou, J. B.; Ntoumba, A. A.; Beglau, T. H. Y.; Tako Djimefo, A. K.; Djuidje, A. G.; Chimi Tchatchouang, G.; Wounang, A. L.; Evouna, M. I. D.; Chameni Nkouankam, M. J.; Dada Youte, Y. P.; Moussa Ndotti, H.; Belle Ebanda Kedi, P.; Enone Bertin, S.; Janiak, C.
10.1101/2024.12.15.628536 — pharmacology and toxicology — Posted on 2024-12-17
2345 Fecal Metabolite Quantitation for Rapid Assessment of the Gut Microbiome
Mullowney, M. W.; Moran, A.; Hernandez, A.; McMillin, M.; Rose, A.; Moran, D.; Little, J.; Nguyen, A. B.; Patel, B. K.; Lehmann, C. J.; Odenwald, M. A.; Pamer, E. G.; Yeo, K.-T. J.; Sidebottom, A. M.
10.1101/2024.12.13.628394 — pathology — Posted on 2024-12-17
2349 Cardiac fibroblasts cellular anisotropy is determined by YAP-dependent cellular contractility and ECM production
Pereira-Sousa, D.; Guillamat, P.; Niro, F.; Vinarsky, V.; Fernandes, S.; Cassani, M.; Pagliari, S.; Trepat, X.; Rasponi, M.; Oliver-De La Cruz, J.; Forte, G.
10.1101/2024.12.14.628335 — cell biology — Posted on 2024-12-17
2350 Differential effects of aging, Alzheimer's pathology, and APOE4 on longitudinal functional connectivity and episodic memory in older adults
Fischer, L.; Adams, J. N.; Molloy, E. N.; Vockert, N.; Tremblay-Mercier, J.; Remz, J.; Binette, A. P.; Villeneuve, S.; PREVENT-AD Research Group, ; Maass, A.
10.1101/2024.12.11.627967 — neuroscience — Posted on 2024-12-17
2351 Multi-Stable Bimodal Perceptual Coding within the Ventral Premotor Cortex
Andrade-Ortega, B.; Diaz, H.; Bayones, L.; Alvarez, M.; Zainos, A.; Rivera-Yoshida, N.; Franci, A.; Romo, R.; Rossi-Pool, R.
10.1101/2024.12.11.628069 — neuroscience — Posted on 2024-12-17
2355 Structural and Mechanistic Insights into Symmetry Conversion in Plant GORK K+ Channel Regulation
Li, Q.-y.; Qin, L.; Tang, L.-h.; Zhang, C.-r.; Huang, S.; Wang, K.; Zhang, G.-h.; Hao, N.-j.; Su, M.; Hedrich, R.; Chen, Y.-h.
10.1101/2024.12.17.628833 — plant biology — Posted on 2024-12-17
2358 A comparative analysis of planarian regeneration specificity reveals tissue polarity contributions of the axial cWnt signalling gradient.
Cleland, J. P.; Vu, H. T.- K.; Dickmann, J. E. M.; Rozanski, A.; Werner, S.; Schuhmann, A.; Shevchenko, A.; Rink, J. C.
10.1101/2024.12.01.626254 — developmental biology — Posted on 2024-12-17
2360 NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress
Amnekar, R.; Dite, T.; Lis, P.; Bell, S.; Brown, F.; Johnson, C.; Wilkinson, S.; Raggett, S.; Dorward, M.; Wightman, M.; Macartney, T.; Soares, R. F.; Lamoliatte, F.; Alessi, D. R.
10.1101/2024.12.12.628181 — cell biology — Posted on 2024-12-17
2362 Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever
Srour, S.; ElGhazaly, M.; O'Connor, D.; Gibani, M. M.; Darton, T. C.; Pollard, A. J.; Collins, M. O.; Humphreys, D.
10.1101/2024.12.13.628371 — microbiology — Posted on 2024-12-17
2363 Mapping Visual Contrast Sensitivity and Vision Loss Across the Visual Field with Model-Based fMRI
Chow-Wing-Bom, H. T.; Lisi, M.; Benson, N. C.; Lygo-Frett, F.; Yu-Wai-Man, P.; Dick, F.; Maimon-Mor, R. O.; Dekker, T. M.
10.1101/2024.10.29.619403 — neuroscience — Posted on 2024-12-17
2364 Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons
Costa, A. C.; Murillo, B. R.; Bessa, R.; Ribeiro, R.; Ferreira da Silva, T.; Porfirio-Rodrigues, P.; Martins, G. G.; Brites, P.; Kneussel, M.; Misgeld, T.; Brill, M. S.; Sousa, M. M.
10.1101/2024.10.10.617525 — neuroscience — Posted on 2024-12-17
2368 Putative neofunctionalization of a Poales-specific EXO70 clade
Bergum, M.; Sklenar, J.; Hernandez-Pinzon, I.; Taylor, J.; Smoker, M.; Samwald, S.; Allen, M.; Thind, A.; Green, P.; Moon, H.; Menke, F. L. H.; Zipfel, C.; Rhodes, J.; Faulkner, C.; Moscou, M. J.
10.1101/2024.12.13.628418 — plant biology — Posted on 2024-12-17
2373 The non-specific phospholipase C of common bean PvNPC4 modulates roots and nodule development
Pacheco, R.; Juarez-Verdayes, M.; Chavez-Martinez, A. I.; Palacios-Martinez, J.; Leija, A.; Nava, N.; Cardenas-Torres, L.; Quinto, C.
10.1101/2024.12.13.628387 — plant biology — Posted on 2024-12-17
2375 Mechanical stress induces anatomical changes, tomato early flowering, and increased yield involving ethylene and auxins
Castro-Estrada, J.; Salazar, S. M.; Mariotti Martinez, J. A.; Cabello, J. V.; Chan, R. L.; Welchen, E.
10.1101/2024.12.15.628576 — plant biology — Posted on 2024-12-17
2376 Mechanical compressive forces increase PI3K output signaling in breast and pancreatic cancer cells
Di-Luoffo, M.; Schmitter, C.; Barrere, E.; Therville, N.; Chaouki, M.; D'Angelo, R.; Arcucci, S.; Thibault, B.; Delarue, M.; Guillermet-Guibert, J.
10.1101/2021.10.18.464825 — cancer biology — Posted on 2024-12-17
2378 Structure-based Design of Chimeric Influenza Hemagglutinins to Elicit Cross-group Immunity
Castro, K. M.; Ayardulabi, R.; Wehrle, S.; Cui, H.; Georgeon, S.; Schmidt, J.; Xiao, S.; Seraj, N.; Harshbarger, W.; Mallett, C. P.; Vassilev, V.; Saelens, X.; Correia, B.
10.1101/2024.12.17.628867 — biochemistry — Posted on 2024-12-17
2383 Metformin inhibits nuclear egress of chromatin fragments in senescence and aging
Kumazawa, T.; Xu, Y.; O'Brien, T.; Lee, J.-W.; Wang, Y.; Cetinbas, M.; Sadreyev, R.; Bardeesy, N.; Cheng, C.-W.; He, B.; Dou, Z.
10.1101/2024.12.16.628669 — cell biology — Posted on 2024-12-17
2384 TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion
Liu, X.; dos Santos, T.; Spigelman, A. F.; Duckett, S.; Smith, N.; Suzuki, K.; MacDonald, P. E.
10.1101/2024.12.16.628242 — cell biology — Posted on 2024-12-17
2385 Outcome-Driven Microscopy: Closed-Loop Optogenetic Control of Cell Biology
Passmore, J.; Rates, A.; Schroeder, J.; Van Laarhoven, M.; Hellebrekers, V.; Van Hoef, H.; Geurts, A.; Van Straaten, W.; Nijenhuis, W.; Berger, F.; Smith, C.; Smal, I.; Kapitein, L.
10.1101/2024.12.12.628240 — cell biology — Posted on 2024-12-17
2386 FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses
Kim, C.; Gabriel, K. R.; Boone, D.; Brown, M. R.; Oppenheimer, K.; Kost-Alimova, M.; Pablo, J. L. B.; Greka, A.
10.1101/2024.12.12.628015 — cell biology — Posted on 2024-12-17
2387 Small-molecule inhibitor of C-terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells
David, C.; Sun, Y.; Woloschin, V.; Vogt, M.; Dienstbier, N.; Schlutermann, D.; Berning, L.; Lungerich, B.; Friedrich, A.; Akgun, S.; Mendiburo, M. J.; Gertzen, C. G. W.; Borkhardt, A.; Wesselborg, S.; Gohlke, H.; Bhatia, S.; Kurz, T.; Stork, B.
10.1101/2024.12.16.628644 — cell biology — Posted on 2024-12-17
2388 PERK Signaling Maintains Hematopoietic Stem Cell Pool Integrity under Endoplasmic Reticulum Stress by Promoting Proliferation
Zheng, M.; Peng, Q.; Kropp, E. M.; Shen, Z.; Liu, S.; Yin, Z.; Matono, S.; Iwawaki, T.; Wang, X.; Inoki, K.; Mei, Y.; Li, Q.; Liu, L.
10.1101/2024.12.13.628451 — cell biology — Posted on 2024-12-17
2390 Cell cycle-regulated transcriptional pausing of Drosophila replication-dependent histone genes
Kemp, J. P.; Geisler, M. S.; Hoover, M.; Cho, C.-Y.; O'Farrell, P. H.; Marzluff, W. F.; Duronio, R. J.
10.1101/2024.12.16.628706 — cell biology — Posted on 2024-12-17
2391 Functional characterization of the store-operated calcium entry pathway in naked mole-rat cells
Drugachenok, P.; Urriola-Munoz, P.; Qui, L.; Zhuang Han, Z.; Smith, E. S. J.; Rahman, T.
10.1101/2024.12.15.628530 — cell biology — Posted on 2024-12-17
2394 Intraflagellar Transport Selectivity Occurs with the Proximal Portion of the Trypanosome Flagellum
Alves, A. A.; Jung, J.; Monneron, G.; Vaucelle, H.; Fort, C.; Buisson, J.; Schietroma, C.; BASTIN, P.
10.1101/2024.12.13.628094 — cell biology — Posted on 2024-12-17
2396 Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease
Chai, R. C.; Lundberg, M.; Freudenthal, B.; Smith, J. T.; Boughton, A. P.; Zhang, Y.; Flynn, K. A.; Frysz, M.; Corr, A. P.; Khoo, W. H.; Komla-Ebri, D.; Dack, M. R. G.; Guilfoyle, S. E.; Logan, J. G.; Butterfield, N. C.; Leitch, V. D.; Pollard, A. S.; Makitie, R. E.; McDonald, M. M.; Youlten, S. E.; Sergio, C. M.; Evans, D. M.; Powell, J. E.; de Leeuw, C. A.; Ewing, A. D.; Eisman, J. A.; Blank, R. D.; Phan, T. G.; International Federation of Musculoskeletal Research Societies (IFMRS) Big Data Working Group, ; Baldock, P. A.; Duncan, E. L.; Williams, G. R.; Bassett, J. H. D.; Croucher, P. I.;
10.1101/2024.12.16.628792 — genetics — Posted on 2024-12-17
2398 The scaffold protein CasL regulates T cell migration by restricting membrane blebbing
Kurtz, L. A.; Shearer, H. E.; Trevail, R.; Symeonides, M.; Karimi, M.; Roy, N. H.
10.1101/2024.12.12.628177 — cell biology — Posted on 2024-12-17
2399 Longitudinal assessment of the conversion of mild cognitive impairment into Alzheimer's dementia: Observations and mechanisms from neuropsychological testing and electrophysiology
Dunstan, D. M.; Barvas, E.; Guttmann, S.; Frusciante, R.; Viti, B.; Volpini, M.; Cannuccia, M.; Monaldini, C.; Tamagnini, F.; Goodfellow, M.; Tait, L.
10.1101/2024.12.16.628666 — neuroscience — Posted on 2024-12-17
2400 ggrain - a ggplot2 extension for raincloud plots
Judd, N.; vanLangen, J.; Poggiali, D.; Whitaker, K.; Rhys Marshall, T.; Allen, M.; Kievit, R.
10.1101/2024.12.13.628294 — scientific communication and education — Posted on 2024-12-17
2401 Biomechanics of stem cell fate decisions in multilayered tissues
Sahu, P.; Canato, S.; Soares, R.; Sanchez-Danes, A.; Hannezo, E.
10.1101/2024.12.12.628138 — biophysics — Posted on 2024-12-17
2406 Causal considerations can determine the utility of machine learning assisted GWAS
Mukherjee, S.; McCaw, Z.; Amar, D.; Dey, R.; Soare, T.; Xu, K.; Somineni, H.; Insitro Research Team, ; Eriksson, N.; O'Dushlaine, C.
10.1101/2024.12.16.628604 — genetics — Posted on 2024-12-17
2407 Coral reef habitat complexity decreases and diversifies local availability of light
Brambilla, V.; Madin, J. S.; Boutros, N.; Fontoura, L.; Hoogenboom, M.; Pizarro, O.; Torres-Pulliza, D.; Williams, S.; Woods, R.; Zawada, K. J.; Dornelas, M.
10.1101/2024.12.12.628134 — ecology — Posted on 2024-12-17
2408 Adhesion-Controlled Mechanics of the Glial Niche Regulate Neural Stem Cell Proliferative Potential
Cristina, A. S.; Briand, D.; Kukde, A.; Perthame, E.; Rigaud, S.; Tinevez, J.-Y.; Banach-Latapy, A.; Owens, N. D. L.; Valon, L.; Bellaiche, Y.; Speder, P.
10.1101/2024.12.11.628019 — developmental biology — Posted on 2024-12-17
2409 Exploring Bioelectricity with Ace2N-mNeon during Zebrafish Embryogenesis
Wu, Z.; Oliveira Silva, R.; Hoessein, R.; Marques Trujillo, F.; Gotti, J.; Ganapathy, S.; Gao, Z.; Brinks, D.
10.1101/2024.12.12.628143 — developmental biology — Posted on 2024-12-17
2410 Morphogenetic constrains in the development of gastruloids: implications for mouse gastrulation
Fiuza, U.-M.; Bonavia, S.; Pascual-Mas, P.; Torregrosa, G.; Casani, P.; Robertson, G.; Martinez Arias, A.
10.1101/2024.12.12.628151 — developmental biology — Posted on 2024-12-17
2413 A CRISPR-associated Rossman-fold Ring Nuclease and Adenosine Deaminase Fusion Allosterically Converts ATP to ITP
Whyms, C. T.; Zhao, Y.; Addo-Yobo, D.; He, H.; Whittington, A. C.; Trasanidou, D.; Salazar, C. R. P.; Staals, R. H. J.; Li, H.
10.1101/2024.12.12.628194 — cell biology — Posted on 2024-12-17
2414 Identification and comparison of orthologous celltypes from primate embryoid bodies shows limits of marker gene transferability
Jocher, J.; Janssen, P.; Vieth, B.; Edenhofer, F. C.; Dietl, T.; Termeg, A.; Geuder, J.; Enard, W.; Hellmann, I.
10.1101/2024.12.12.628179 — cell biology — Posted on 2024-12-17
2420 Single cell landscape of sex differences in the progression of multiple sclerosis
Soler-Saez, I.; Gomez-Cabanes, B.; Grillo-Risco, R.; Galiana-Rosello, C.; Barea-Moya, L.; Carceller, H.; Dolader-Rabinad, B.; del Rey-Diez, N.; Casanova-Ferrer, F.; Gordillo-Gonzalez, F.; Yanguas-Casas, N.; de la Iglesia-Vaya, M.; Gil-Perotin, S.; Tepavcevic, V.; Hidalgo, M. R.; Garcia-Garcia, F.
10.1101/2024.06.15.599139 — neuroscience — Posted on 2024-12-17
2421 A fuzzy sequencer for rapid DNA fragment counting and genotyping
Zhou, W.; Kang, L.; Qiao, S.; Duan, H.; Yin, C.; Liu, C.; Liao, Z.; Tang, M.; Zhang, R.; Li, L.; Shi, L.; Du, M.; Wang, Y.; Yue, W.; Xiao, Y.; Di, L.; Zhang, X.; Pang, Y.; Li, M.; Ren, L.; Wang, J.; Chen, Z.; Huang, Y.
10.1101/2023.10.24.563729 — genomics — Posted on 2024-12-17
2423 Incomplete lineage sorting of segmental duplications defines the human chromosome 2 fusion site early during African great ape speciation
Jiang, X.; Zhang, L.; Yang, Z.; Yang, X.; Ma, K.; Yoo, D.; Lu, Y.; Zhang, S.; Nie, Y.; Bian, X.; Han, J.; Fu, L.; Zhang, J.; Zhang, G.; Sun, Q.; Eichler, E. E.; Mao, Y.
10.1101/2024.12.12.628057 — evolutionary biology — Posted on 2024-12-17
2424 VARIATION IN HEAD AND PINNA MORPHOLOGY OF PRESERVED PEROMYSCUS SPP. SPECIMENS AND IMPLICATIONS FOR AUDITORY FUNCTION
Sergott, C. E.; Rodman, K.; Greene, N. T.; Li, B.-Z.; Alarcon, G. A.; Machado, F. A.; McCullagh, E. A.
10.1101/2024.12.12.628269 — evolutionary biology — Posted on 2024-12-17
2425 Genetic basis of an adaptive polymorphism controlling butterfly silver iridescence
Livraghi, L.; Hanly, J. J.; Loh, L. S.; Henry, A.; Keck, C. M. T.; Shirey, V. M.; Tsai, C.-C.; Yu, N.; Van Belleghem, S. M.; Roberts, W. M.; Boggs, C. L.; Martin, A.
10.1101/2024.12.13.628425 — evolutionary biology — Posted on 2024-12-17
2428 Unprecedented female mutation bias in aye-ayes
Wang, R. J.; Pena-Garcia, Y.; Raveendran, M.; Harris, R. A.; Nguyen, T.-T.; Gingras, M.-C.; Wu, Y.; Perez, L. M.; Yoder, A. D.; Simmons, J. H.; Rogers, J.; Hahn, M. W.
10.1101/2024.12.13.628352 — evolutionary biology — Posted on 2024-12-17
2429 The Blueprint for Survival: The Blue Dasher Dragonfly as a Model for Urban Adaptation
Tolman, E. R.; Gamett, E.; Beatty, C. D.; Goodman, A.; Hahn, B.; Benischek, C.; Castillo, G.; Derdarian, E.; Fernandez-Juarez, S.; Gallafent, B.; Jenson, J.; Jordan, D.; Schneider, M.; Salazar, R.; Tamano, T.; Wei, M.; Idec, J.; Guralnick, R.; Ware, J. L.; Kohli, M. K.
10.1101/2024.12.12.628234 — evolutionary biology — Posted on 2024-12-17
2430 Persistent genomic erosion in whooping cranes despite demographic recovery
Fontsere, C.; Speak, S. S.; Caven, A. J.; Rodriguez, J. A.; Wang, X.; Pacheco, C.; Cassatt-Johnstone, M.; Femerling, G.; Maloney, B.; Balacco, J.; Collins, J.; Sims, Y.; Abueg, L.; Fedrigo, O.; Jarvis, E. D.; Hartup, B. K.; Shapiro, B.; Gilbert, M. T. P.; van Oosterhout, C.; Morales, H. E.
10.1101/2024.12.12.628160 — evolutionary biology — Posted on 2024-12-17
2434 Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across 5 fly Parkinsonism models
Pech, U.; Janssens, J.; Schoovaerts, N.; Kuenen, S.; Calatayud Aristoy, C.; Gallego, S. F.; Makhzami, S.; Hulselmans, G.; Poovathingal, S.; Davie, K.; Bademosi, A. T.; Swerts, J.; Vilain, S. P.; Aerts, S.; Verstreken, P.
10.1101/2023.03.11.532176 — neuroscience — Posted on 2024-12-17
2435 Synergistic Neural Circuits for Novelty and Goal-Directed Behavior
Elliott, B. L.; O'Brien, K.; Fain, M.; Ellman, L. M.; Murty, V. P.
10.1101/2024.12.16.628816 — neuroscience — Posted on 2024-12-17
2436 GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine
Yamamoto, T.; Ueji, K.; Mizuta, H.; Inui-Yamamoto, C.; Kumamoto, N.; Shibata, Y.; Ugawa, S.
10.1101/2024.08.30.610470 — neuroscience — Posted on 2024-12-17
2438 A reaction norm for flowering time plasticity reveals physiological footprints of maize adaptation
Drouault, J.; Palaffre, C.; Millet, E. J.; Rodriguez, J.; Martre, P.; Johnson, K.; Parent, B.; Welcker, C.; Wisser, R. J.
10.1101/2024.07.10.602692 — plant biology — Posted on 2024-12-17
2444 Restoring Oscillatory Dynamics in Alzheimer's Disease: A Laminar Whole-Brain Model of Serotonergic Psychedelic Effects
Gendra, J. C.; Lopez-Sola, E.; Castaldo, F.; Lleal-Custey, E.; Sanchez-Todo, R.; Vohryzek, J.; Salvador, R.; Ruffini, G.
10.1101/2024.12.15.628565 — neuroscience — Posted on 2024-12-16
2449 Dynamic Gamma Modulation of Hippocampal Place Cells Predominates Development of Theta Sequences
Wang, N.; Wang, Y.; Guo, M.; Wang, L.; Wang, X.; Zhu, N.; Yang, J.; Wang, L.; Zheng, C.; Ming, D.
10.1101/2024.03.27.586908 — neuroscience — Posted on 2024-12-16
2451 Food quality and vgll3 genotype influence reproductive traits in female Atlantic salmon
Maamela, K. S.; Asheim, E. R.; O'Sullivan, R. J.; Debes, P. V.; House, A. H.; Liljeström, P.; Prokkola, J. M.; Niemelä, P. T.; Erkinaro, J.; Mobley, K. B.; Primmer, C. R.
10.1101/2024.12.12.628099 — evolutionary biology — Posted on 2024-12-16
2456 Tissue-specific apparent mtDNA heteroplasmy and its relationship with ageing and mtDNA gene expression
Wengert, S.; Giannoulis, X.; Kreitmaier, P.; Kautz, P.; Ludwig, L. S.; Prokisch, H.; Casale, F. P.; Heinig, M.; Cai, N.
10.1101/2024.12.11.627989 — genomics — Posted on 2024-12-16
2458 The evolution of weaponry and aggressive behaviour in field crickets
Judge, K. A.; Smith, B. E.; Ohlmann, S. L.; Steckler, D. K.; Kellington, A. T.; Cade, W. H.
10.1101/2024.12.11.627984 — evolutionary biology — Posted on 2024-12-16
2459 Structural rearrangements and selection promote phenotypic evolution in Anolis lizards
Araya Donoso, R.; Baty, S. M.; Johnson, J. E.; Lasku, E.; Taft, J.; Fisher, R.; Losos, J. B.; Dolby, G.; Kusumi, K.; Geneva, A.
10.1101/2024.12.12.628123 — evolutionary biology — Posted on 2024-12-16
2463 Future climate and land use change will equally impact global terrestrial vertebrate diversity
Hari, C.; Hickler, T.; Hof, C.; Reyer, C. P. O.; Vanderkelen, I.; Voskamp, A.; Biber, M. F.; Fischer, M.; Davin, E. L.
10.1101/2024.12.13.627895 — ecology — Posted on 2024-12-16
2466 DIYNAFLUOR: An Affordable DIY Plug-and-Play Nucleic Acid Fluorometer for eDNA Quantification in Resource Limited Settings
Anderson, W.; Antaw, F.; Kenny, S.; Rupani, H.; Khamis, R.; Constantin, N.; Kumar, V.; Gemmell, A.; Bell, C.; Trau, M.; Korbie, D.
10.1101/2024.12.16.626200 — molecular biology — Posted on 2024-12-16
2468 Proteomic Sensors for Quantitative, Multiplexed and Spatial Monitoring of Kinase Signaling
Comstock, W. J.; Navarro, M. V.; Maybee, D. V.; Rho, Y.; Wagner, M.; Wang, Y.; Smolka, M. B.
10.1101/2024.12.16.628391 — molecular biology — Posted on 2024-12-16
2469 Prefrontal cortex dopamine responds to the total valence of stimuli
Yang, Y.; Parent, W.; Rice, H. J.; Mark, R.; Desimone, M.; Rahman, M.; Ellwood, I. T.
10.1101/2024.12.11.627942 — neuroscience — Posted on 2024-12-16
2472 A Model of Place Field Reorganization During Reward Maximization
Kumar, M. G.; Bordelon, B.; Zavatone-Veth, J. A.; Pehlevan, C. A.
10.1101/2024.12.12.627755 — neuroscience — Posted on 2024-12-16
2473 Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophage
Rozum, J. C.; Sineath, W. D.; Kim, D. N.; Bohutskyi, P.; Johnson, C. G.; Evans, J. E.; Pollock, D. D.; QIAN, W.-J.; Cheung, M. S.; Wu, R.; Feng, S.
10.1101/2024.12.11.628001 — systems biology — Posted on 2024-12-16
2475 Genetic silencing of KCa3.1 inhibits atherosclerosis in ApoE null mice
Alam, P.; Tharp, D. L.; Bowles, H. J.; Grisanti, L.; Bui, H. S.; Bender, S. B.; Bowles, D. K.
10.1101/2024.12.11.628017 — physiology — Posted on 2024-12-16
2476 Knock-in Kcnh2 Rabbit Model of Long QT Syndrome Type-2, Epilepsy, and Sudden Death
Singh, V.; Wagner, K. T.; Williams, L. G.; Ryan, J. M.; Keller, K. R.; Mohnkern, J. D.; Gardner, R. S.; Dang, L. T.; Ziobro, J. M.; Wiojcikiewicz, R. J. H.; Tucker, N. R.; Auerbach, D. S.
10.1101/2024.12.11.627988 — physiology — Posted on 2024-12-16
2478 Novel immunotherapy for multiple solid cancers using an Anti-HVEM blocking monoclonal antibody
Galore-Haskel, G.; Merhavi-Shoham, E.; Shapiro, M.; Bareli, R.; Dror, N.; Seliktar-Ofir, S.; Shamalov, K.; Levy-Barda, A.; Hout-Siloni, G.; Schachter, J.; Sadot, E.; Eitan, R.; Barshack, I.; Golan, S.; Feferman, Y.; Yeoshoua, E.; Eyadat, S.; Greenberg, E.; Markel, G.
10.1101/2024.12.16.627913 — cancer biology — Posted on 2024-12-16
2479 A precision oncology-focused deep learning framework for personalized selection of cancer therapy
Sederman, C.; Yang, C.-H.; Cortes-Sanchez, E.; Di Sera, T.; Huang, X.; Scherer, S. D.; Zhao, L.; Chu, Z.; White, E. R.; Atkinson, A.; Wagstaff, J.; Varley, K. E.; Lewis, M. T.; Qiao, Y.; Welm, B. E.; Welm, A. L.; Marth, G. T.
10.1101/2024.12.12.628190 — cancer biology — Posted on 2024-12-16
2482 FeatureForest: the power of foundation models, theusability of random forests
Seifi, M.; Dalle Nogare, D.; Battagliotti, J.; Galinova, V.; Rao, A. K.; AI4Life Horizon Europe Programme Consortium, ; Decelle, J.; Jug, F.; Deschamps, J.
10.1101/2024.12.12.628025 — bioinformatics — Posted on 2024-12-16
2487 The multi-scale complexity of human genetic variation beyond continental groups
Palma-Martinez, M. J.; Posadas-Garcia, Y. S.; Lopez-Angeles, B. E.; Quiroz-Lopez, C.; Lewis, A. C. F.; Bird, K. A.; Lasisi, T.; Zaidi, A. A.; Sohail, M.
10.1101/2024.12.11.627824 — genomics — Posted on 2024-12-16
2489 Supergene evolution via gain of auto-regulation
VanKuren, N. W.; Sheikh, S. I.; Fu, C. L.; Massardo, D.; Lu, W.; Kronforst, M. R.
10.1101/2024.01.09.574839 — evolutionary biology — Posted on 2024-12-16
2490 Contrasting impacts of invasive Opuntia cacti on mammal habitat use
Stewart, P. S.; Hill, R. A.; Oduor, A. M. O.; Stephens, P. A.; Whittingham, M. J.; Dawson, W.
10.1101/2024.12.12.627951 — ecology — Posted on 2024-12-16
2491 Divergent regulatory element programs steer sex-specific supporting cell differentiation along mouse gonadal development
Stevant, I.; Abberbock, E.; Ridnik, M.; Weiss, R.; Swisa, L.; Futtner, C.; Maatouk, D.; Lovell-Badge, R.; Malysheva, V.; Gonen, N.
10.1101/2024.12.09.627451 — developmental biology — Posted on 2024-12-16
2492 Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer
Chen, K.-E.; Tillu, V. A.; Gopaldass, N.; Chowdhury, S. R.; Leneva, N.; Kovtun, O.; Ruan, J.; Guo, Q.; Ariotti, N.; Mayer, A.; Collins, B. M.
10.1101/2024.03.24.586500 — cell biology — Posted on 2024-12-16
2493 Maf1 Cooperates with Progesterone Receptor to Repress RNA Polymerase III Transcription of Select tRNAs
Finlay-Schultz, J.; Paul, k. V.; Erickson, B.; Fettig, L. M.; Hastings, B. S.; Johnson, D. L.; Bentley, D. L.; Kabos, P.; Sartorius, C. A.
10.1101/2024.12.16.628719 — molecular biology — Posted on 2024-12-16
2494 Localized translation of cell junction mRNAs is required for epithelial cell polarity
Chin, A.; Bergeman, J.; Communal, L.; Boulais, J.; Mes-Masson, A.-M.; Lecuyer, E.
10.1101/2024.12.16.628746 — molecular biology — Posted on 2024-12-16
2495 Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress
Wilkins, R. J.; Kannan, A.; Plass, S. A.; Wilson, C.; Kelly, R. D. W.; Tang, C. H. M.; Kotsantis, P.; Reijns, M. A. M.; Kanhere, A.; Petermann, E.
10.1101/2024.12.16.628316 — molecular biology — Posted on 2024-12-16
2496 Emergence and Dynamics of Usutu and West Nile Viruses in the Netherlands, 2016-2022
Munger, E.; Atama, N.; van Irsel, J.; Blom, R.; Krol, L.; van den Berg, T. J.; Braks, M.; de Vries, A.; van der Linden, A.; Chestakova, I.; Boter, M.; Chandler, F. D.; Kohl, R.; Nieuwenhuijse, D. F.; Uiterwijk, M.; Fouchier, R. A. M.; Sprong, H.; Grone, A.; Koenraadt, C. J. M.; Schrama, M.; Reusken, C. B. E. M.; Stroo, A.; van den Brand, J. M. A.; van der Jeugd, H. P.; Oude Munnink, B. B.; Sikkema, R. S.; Koopmans, M. P. G.
10.1101/2024.12.16.628479 — microbiology — Posted on 2024-12-16
2497 Morphotype-Resolved Characterization of Microalgal Communities in a Nutrient Recovery Process with ARTiMiS Flow Imaging Microscopy
Gincley, B.; Khan, F.; Alam, M. M.; Hartnett, E.; Kim, G.-Y.; Molitor, H.; Fisher, A.; Bradley, I.; Guest, J.; Pinto, A. J.
10.1101/2024.12.16.628756 — microbiology — Posted on 2024-12-16
2499 IgA displays site- and subclass-specific glycoform differences despite equal glycoenzyme expression
Falck, D.; Sokolova, M. V.; Koeleman, C. A. M.; Irumva, V.; Kirchner, P.; Schulz, S. R.; Schmidt, K. G.; Harrer, T.; Ekici, A. B.; Spriewald, B.; Schett, G.; Wuhrer, M.; Herrmann, M.; Steffen, U.
10.1101/2024.12.11.627887 — immunology — Posted on 2024-12-16
2500 A central role for CCR2 in monocyte recruitment and blood-brain barrier disruption during Usutu virus encephalitis
Slowikowski, E.; Willems, C.; Lemes, R. M. R.; Schuermans, S.; Berghmans, N.; Rocha, R. P. F.; Martens, E.; Proost, P.; Delang, L.; Marques, R. E.; Alves-Filho, J. C.; Marques, P. E.
10.1101/2024.12.12.627941 — immunology — Posted on 2024-12-16
2501 Divergent effects of cytomegalovirus and rheumatoid arthritis on senescent CD4+ T cells
Williams, L.; Saber, A. O.; Xu, R.; Jung, H.; Awad, S.; Shahane, A.; Baker, J. F.; Su, L. F.
10.1101/2024.12.11.627966 — immunology — Posted on 2024-12-16
2502 T-type calcium channels participate in intrinsic and synaptic activity of PKCγ neurons of the dorsal horn of the spinal cord during chronic pain
Cuculiere, C.; Bourdon-Alonzeau, R.; Rulhe, C.; Chemin, J.; Francois, A.; Blanchard, M.-P.; Fontanaud, P.; Deval, E.; Mangoni, M.; Lingueglia, E.; Bourinet, E.; Mery, P.-F.
10.1101/2024.12.11.627933 — neuroscience — Posted on 2024-12-16
2504 Modulating Prestimulus Alpha and Beta Power with tRNS Establishes Their Causal Role in Visual Perception
Wei, J.; Zou, H.; Tang, Q.; Yao, Z.; Huang, G.; Liang, Z.; Zhang, L.; Zhou, C.; Zhang, Z.
10.1101/2024.12.11.627917 — neuroscience — Posted on 2024-12-16
2505 Random Tree Model of Meaningful Memory
Zhong, W.; Can, T.; Georgiou, A.; Shnayderman, I.; Katkov, M.; Tsodyks, M.
10.1101/2024.12.11.627835 — neuroscience — Posted on 2024-12-16
2508 Mapping targetable sites on the human surfaceome for the design of novel binders
Balbi, P. E. M.; Sadek, A.; Marchand, A.; Yu, T.; Damjanovic, J.; Georgeon, S.; Schmidt, J.; Fulle, S.; Yang, C.; Khakzad, H.; Correia, B.
10.1101/2024.12.16.628626 — synthetic biology — Posted on 2024-12-16
2510 The Chlamydomonas reinhardtii CLiP2 mutant collection expands genome coverage with high-confidence disrupting alleles
Lunardon, A.; Patena, W.; Pacini, C.; Warren-Williams, M.; Zubak, Y.; Laudon, M.; Silflow, C.; Lefebvre, P.; Jonikas, M. C.
10.1101/2024.12.16.626622 — plant biology — Posted on 2024-12-16
2511 Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations
Yu, J. X.; Suh, J. M.; Popova, K. D.; Garcia, K.; Joshi, T.; Culbertson, B.; Spinelli, J. B.; Subramanyam, V.; Lou, K.; Shokat, K. M.; Weissman, J.; Goodarzi, H.
10.1101/2024.12.13.628239 — cancer biology — Posted on 2024-12-16
2512 PARP inhibitor counteracts Temozolomide Resistance in Glioblastoma Multiforme
Samarut, E.; Tabourel, G.; Briand, J.; Landais, Y.; Gratas, C.; Cartron, P.-F.; Vallette, F.; Oliver, L.; Serandour, A. A.
10.1101/2024.12.13.627927 — cancer biology — Posted on 2024-12-16
2514 An artificial intelligence-based model for prediction of Clonal Hematopoiesis mutants in cell-free DNA samples
Arango-Argoty, G.; Haghighi, M.; Sun, G. J.; Markovets, A.; Barrett, J. C.; Lai, Z.; Jacob, E.
10.1101/2024.12.11.627785 — bioinformatics — Posted on 2024-12-16
2515 Simulating Alpha Particle Doses at the Micron Scale from Prostate Cancer Patient Derived Bone Metastatic Biopsies Using GATE
Said, A.; Hamdi, M.; Salerno, I.; Benabdallah, N.; Turtle, N. F.; Abou, D.; Thomas, M. A.; Mikell, J.; Thorek, D. L.
10.1101/2024.12.11.627943 — bioengineering — Posted on 2024-12-16
2518 Efficient cell-free translation from diverse human cell types
Ziegelmueller, J.; Kouvelas, N.; Thambythurai, P.; Hofer, A.; Muehlemann, O.; Karousis, E. D.
10.1101/2024.12.16.628677 — biochemistry — Posted on 2024-12-16
2520 A New Approach to Monitoring Protein Transfer via Extracellular Vesicles
Pigden, O.; Chabronova, A.; Jenkins, R.; Jensen, A.; Clarke, E.; James, V.; Peffers, M. J.
10.1101/2024.12.16.628642 — molecular biology — Posted on 2024-12-16
2522 A novel SARS-CoV-2-derived infectious vector system
Elfayres, G.; Xiao, Y.; Pan, Q.; Liang, C.; Barbeau, B.; Berthoux, L.
10.1101/2024.12.16.628561 — microbiology — Posted on 2024-12-16
2523 Tunicate metatranscriptomes reveal ancient virus-host co-divergence and inter-order recombination in the evolutionary history of disease-causing viruses
Petrone, M. E.; Grove, J.; Parry, R.; Van Brussel, K.; Mifsud, J. C.; Dindar, Z.; Mei, S.-q.; Shi, M.; Turnbull, O. M.; Marzinelli, E. M.; Holmes, E. C.
10.1101/2024.12.15.628590 — microbiology — Posted on 2024-12-16
2524 Hypoxia-inducible-factors differentially contribute to clinical disease and the control of viral replication during RSV infection
Morris, D. R.; Qu, Y.; Haas de Mello, A.; Jones-Hall, Y. L.; Liu, T.; Weglarz, M.; Ivanciuc, T.; Garofalo, R. P.; Casola, A.
10.1101/2023.08.15.553422 — microbiology — Posted on 2024-12-16
2525 Tax1bp1 enhances bacterial virulence and promotes inflammatory responses during Mycobacterium tuberculosis infection of alveolar macrophages
Chin, J.; Abeydeera, N.; Repasy, T.; Rivera-Lugo, R.; Mitchell, G.; Nguyen, V. Q.; Zheng, W.; Richards, A.; Swaney, D. L.; Krogan, N. J.; Ernst, J. D.; Cox, J. S.; Budzik, J. M.
10.1101/2024.12.16.628616 — microbiology — Posted on 2024-12-16
2527 The methane-cycling microbiome in intact and degraded permafrost soils of the pan-Arctic
Wang, H.; Lindemann, E.; Liebmann, P.; Varsadiya, M.; Svenning, M. M.; Waqas, M.; Petters, S.; Richter, A.; Guggenberger, G.; Barta, J.; Urich, T.
10.1101/2024.12.16.628686 — microbiology — Posted on 2024-12-16
2531 NK cells control the progression of myelodysplastic syndrome but become initial disease target in NUP98-HOXD13 mouse model
Telliam Dushime, G.; Ciesla, M.; Lilljebjorn, H.; Ungerback, J.; Yuan, O.; Vo, D. N.; Kotova, O.; Fioretos, T.; Bryder, D.; Bellodi, C.; Sitnicka, E.
10.1101/2024.12.11.627924 — immunology — Posted on 2024-12-16
2532 Intentionally vs. Spontaneously Prolonged Gaze: A MEG Study of Active Gaze-Based Interaction
Vasilyev, A. N.; Svirin, E. P.; Dubynin, I. A.; Butorina, A. V.; Nuzhdin, Y. O.; Ossadtchi, A. E.; Stroganova, T. A.; Shishkin, S. L.
10.1101/2024.12.11.627776 — neuroscience — Posted on 2024-12-16
2536 Microthrombi-growth in ADAMTS13 deficiency exacerbated ulcerative colitis via mucosal and endothelial dysfunction
Tatsuta, K.; Honkura, N.; Morooka, N.; Sakata, M.; Kurachi, K.; Sugimoto, K.; Kokame, K.; Takeuchi, H.; Urano, T.; Suzuki, Y.
10.1101/2024.12.10.627861 — physiology — Posted on 2024-12-16
2537 Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem
Coleon, A.; Larrous, F.; Kergoat, L.; Tichit, M.; Hardy, D.; Obadia, T.; Kornobis, E.; Bourhy, H.; de Melo, G. D.
10.1101/2024.12.16.628627 — pathology — Posted on 2024-12-16
2542 Highly dynamic supernumerary mini-chromosomes in a Magnaporthe oryzae strain
Lin, G.; Zheng, H.; Koo, D.-H.; Wang, Z.; Cook, D.; Valent, B.; Liu, S.
10.1101/2024.12.10.627822 — genomics — Posted on 2024-12-16
2543 Adaptation to heavy-metal contaminated environments proceeds via selection on pre-existing genetic variation
Wright, K. M.; Gaudinier, A.; Hellsten, U.; Jeong, A. L.; Sreedasyam, A.; Holalu, S.; Flores Vegara, M.; Rojas Carvajal, A.; Antelope, C.; Chapman, J. A.; Franks, R. G.; Grimwood, J.; Barry, K. W.; Jenkins, J. W.; Lovell, J. T.; Coop, G.; Schmutz, J.; Kelly, J. K.; Rokhsar, D. S.; Blackman, B. K. M.; Willis, J. H.
10.1101/029900 — evolutionary biology — Posted on 2024-12-16
2547 Integration of sexual dimorphism and left-right asymmetry in the development of the duck syrinx
Mishkind, D.; Lee, C.; Prabhakara, C.; Tir, P.; Kingsley, E. P.; Clarke, J. A.; Goller, F.; Tabin, C. J.
10.1101/2024.12.10.627783 — developmental biology — Posted on 2024-12-16
2553 Voxel-wise or Region-wise Nuisance Regression for Functional Connectivity Analyses: Does it matter?
Muganga, T.; Sasse, L.; Larabi, D. I.; Nieto, N.; Caspers, J.; Eickhoff, S. B.; Patil, K. R.
10.1101/2024.12.10.627766 — neuroscience — Posted on 2024-12-16
2557 Early development of the glucocorticoid stress response in dyeing poison frog tadpoles
Surber, L. L.; Jimenez, L. S.; Mobo, L. W.; Westrick, S. E.; Fischer, E. K.
10.1101/2024.05.31.596457 — physiology — Posted on 2024-12-16
2559 Neonatal systemic gene therapy restores cardiorespiratory function in a rat model of Pompe disease
Fuller, D.; Rana, S.; Thakre, P.; Benevides, E. S.; Pope, M.; Todd, A. G.; Jensen, V.; Vaught, L.; Ribas, R. A.; Larson, R. C.; Gentry, M. S.; sun, r. c.; Chandran, V.; Corti, M.; Falk, D. J.; Byrne, B. J.
10.1101/2024.12.10.627800 — physiology — Posted on 2024-12-16
2561 Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling
Nakagawa, R.; Beardsley, A.; Durney, S.; Hayward, M.-K.; Subramanyam, V.; Meyer, N. P.; Wismer, H.; Goodarzi, H.; Weaver, V. M.; Van de Mark, D.; Goga, A.
10.1101/2024.09.26.615226 — cancer biology — Posted on 2024-12-16
2562 Automating Candidate Gene Prioritization with Large Language Models: Development and Benchmarking of an API-Driven Workflow Leveraging GPT-4
khan, T.; Toufiq, M.; Yurieva, M.; Indrawattana, N.; Jittmittraphap, A.; Kosoltanapiwat, N.; Pumirat, P.; Sukphopetch, P.; Vanaporn, M.; Kaber, B.; Palucka, K.; Rinchai, D.; Chaussabel, D.
10.1101/2024.12.10.627808 — bioinformatics — Posted on 2024-12-16
2563 Structural basis for regulation of CELSR1 by a compact module in its extracellular region
Bandekar, S. J.; Garbett, K.; Kordon, S. P.; Dintzner, E.; Li, J.; Shearer, T.; Sando, R.; Arac, D.
10.1101/2024.01.26.577439 — biochemistry — Posted on 2024-12-16
2564 DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project
Mariner, B. L.; McCoy, B. M.; Greenier, A.; Brassington, L.; Slikas, E.; Adjangba, C.; Marye, A.; Harrison, B. R.; Bamberger, T.; Algavi, Y.; Muller, E.; Harris, A.; Rout, E.; The Dog Aging Project Consortium, ; Avery, A.; Borenstein, E.; Promislow, D.; Snyder-Mackler, N.
10.1101/2024.10.08.617286 — genomics — Posted on 2024-12-16
2565 Estimating and correcting index hopping misassignments in single-cell RNA-seq data
Miao, L.; Collado, L.; Barkdull, S.; Saito, Y.; Jo, J.-H.; Han, J.; DellOrso, S.; Kelly, M. C.; Kong, H. H.; Brownell, I.
10.1101/2024.10.21.619353 — genomics — Posted on 2024-12-16
2566 Efficient assembly of plant genomes: A case study with evolutionary implications in Ranunculus (Ranunculaceae)
Karbstein, K.; Choudhary, N.; Xie, T.; Tomasello, S.; Wagner, N. D.; Barke, B. H.; Paetzold, C.; Bradican, J. P.; Preick, M.; Himmelbach, A.; Stein, N.; Papantonis, A.; Irisarri, I.; de Vries, J.; Pucker, B.; Hoerandl, E.
10.1101/2023.08.08.552429 — genomics — Posted on 2024-12-16
2569 Identification of Myeloid Protein Kinase C - Epsilon as a Novel Atheroprotective Gene
Wells, A. T.; Shen, M. M.; Binrouf, R. H.; D'Amico, A. E.; Bossardi Ramos, R.; Lennartz, M. R.
10.1101/2024.12.09.627650 — immunology — Posted on 2024-12-16
2571 P23H rhodopsin aggregation in the ER causes synaptic protein imbalance in rod photoreceptors
Thompson, S.; Crowder, S. M.; Hekmatara, M.; Sechrest, E. R.; Deng, W.-T.; Robichaux, M. A.
10.1101/2024.10.18.619115 — neuroscience — Posted on 2024-12-16
2572 Developmental, regenerative, and behavioral dynamics in acoel reproduction
Chandra, V.; Tseng, S. E.; Kann, A. P.; Bolanos, D. M.; Srivastava, M.
10.1101/2024.07.09.602770 — zoology — Posted on 2024-12-16
2573 The Molecular Architecture of Variable Lifespan in Diversity Outbred Mice
Hackett, S. R.; Magzoub, M. M.; Maile, T. M.; Vu, N.; Wright, K. M.; Melamud, E.; Haas, W.; McAllister, F. E.; Churchill, G. A.; Bennett, B. D.
10.1101/2023.10.26.564069 — systems biology — Posted on 2024-12-16
2574 Genome composition predicts physiological responses to temperature in polyploid salamanders
Burger, I.; Itgen, M.; Tan, L.; Woodward, P.; Rivas, L.; Hunt, T.; Ready, H.; Martin Geronimo, X.; Denton, R.; Riddell, E.
10.1101/2024.09.06.611688 — physiology — Posted on 2024-12-16
2575 Pain distribution can be determined by classical conditioning
Nastaj, J.; Skalski, J.; Nowak, D.; Kruszyna, N.; Babel, P.; Szikszay, T.; Luedtke, K.; Gnat, R.; Adamczyk, W. M.
10.1101/2024.08.31.609921 — physiology — Posted on 2024-12-16
2576 Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics
Papadopoli, D.; Palia, R.; Jovanovic, P.; Tabaries, S.; Ciccolini, E.; Sabourin, V.; Igelmann, S.; McLaughlan, S.; Zhan, L.; Kim, H.; Chekkal, N.; Szkop, K. J.; Bertomeu, T.; Zeng, J.; Vassalakis, J.; Afzali, F.; Mzoughi, S.; Guccione, E.; Tyers, M.; Avizonis, D.; Larsson, O.; Postovit, L.-M.; Djuranovic, S.; Ursini-Siegel, J.; Siegel, P. M.; Pollak, M.; Topisirovic, I.
10.1101/2024.10.25.620155 — cancer biology — Posted on 2024-12-16
2577 Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging
Cheng, H.; Miller, D.; Southwell, N.; Porcari, P.; Fischer, J.; Taylor, I.; Salbaum, M.; Kappen, C.; Hu, F.; Yang, C.; Keshari, K. R.; Gross, S.; D'Aurelio, M.; Chen, Q.
10.1101/2024.01.10.575105 — bioinformatics — Posted on 2024-12-16
2581 β-Catenin associates with a Wnt signaling mRNA network in myeloid cells through canonical RBP binding.
Wagstaff, M.; Sevim, O.; Goff, A.; Raynor, M.; Park, H.; Mancini, E.; Nguyen, D. T.; Chevassut, T.; Blair, A.; Castellano, L.; Newbury, S. F.; Towler, B. P.; Morgan, R. G.
10.1101/2024.01.28.577638 — cell biology — Posted on 2024-12-16
2582 Test-retest reliability of auditory MMN measured with OPM-MEG
Demko, L.; Iglesias, S.; Mellor, S.; Bassi, C.; Brand, K.; Kalberer, A.; Koechli, L.; Marino, S.; Zimmermann, N. D.; Heinzle, J.; Stephan, K. E.
10.1101/2024.12.10.627674 — neuroscience — Posted on 2024-12-16
2584 Muscle spindles provide flexible sensory feedback for movement sequences
Olson, W. P.; Chokshi, V. B.; Kim, J. J.; Cowan, N.; O'Connor, D. H.
10.1101/2024.09.13.612899 — neuroscience — Posted on 2024-12-16
2585 Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer
Yue, F.; Ku, A. T.; Stevens, P.; Michalski, M.; Jiang, W.; Tu, J.; Shi, Z.; Dou, Y.; Wang, Y.; Feng, X.-H.; Hostetter, G.; Wu, X.; Huang, S.; Shroyer, N.; Zhang, B.; Williams, B.; Liu, Q.; Lin, X.; Li, Y.
10.1101/2024.01.10.574969 — cancer biology — Posted on 2024-12-16
2586 I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation
Fu, Z.; Geisbrecht, B. V.; Bouyain, S.; Dyda, F.; Chrzas, J. J.; Kandavelu, P.; Miller, D. J.; Wang, B.-C.
10.1101/2024.12.10.627855 — biophysics — Posted on 2024-12-16
2589 Long-read sequencing transcriptome quantification with lr-kallisto
Loving, R. K.; Sullivan, D. K.; Reese, F.; Rebboah, E.; Sakr, J.; Rezaie, N.; Liang, H. Y.; Filimban, G.; Kawauchi, S.; Oakes, C.; Trout, D.; Williams, B. A.; MacGregor, G.; Wold, B.; Mortazavi, A.; Pachter, L.
10.1101/2024.07.19.604364 — bioinformatics — Posted on 2024-12-16
2590 In vitro FLASH irradiation of A549 lung cancer cells and IMR90 healthy human fibroblasts in the synchrocyclotron room of a clinical proton therapy system
Zazpe, A.; del Monte-Garcia, I.; Palao, N.; Cerron, F.; Cueto-Remacha, M.; Paula Linzoain-Agos, P.; Iniesta-Gonzalez, M.; Quartieri, M.; Cuesta, A. M.; Espana, S.; Velasco, G.; Vera-Sanchez, J. A.; Fraile, L. M.; Mazal, A.; Udias, J. M.; Porras, A.; Bragado, P.; Gutierrez-Uzquiza, A.; Sanchez-Parcerisa, D.
10.1101/2024.11.13.623375 — bioengineering — Posted on 2024-12-16
2595 Diverse patterns of intra-host genetic diversity in chronically infected SARS-CoV-2 patients
Rutsinsky, N.; Ben Zvi, A.; Fabian, I.; Segev, S. T.; Jacobi, B.; Harari, S.; Meijer, S.; Paran, Y.; Stern, A.
10.1101/2024.11.23.624482 — evolutionary biology — Posted on 2024-12-16
2596 Resource partitioning in organosulfonate utilization by free-living heterotrophic bacteria during a North Sea microalgal bloom
Sidhu, C.; Bartosik, D.; Kale, V.; Trautwein-Schult, A.; Becher, D.; Schweder, T.; Amann, R.; Teeling, H.
10.1101/2024.12.10.627767 — ecology — Posted on 2024-12-16
2597 Pinging the Hidden Attentional Priority Map: Suppression Needs Attention
Huang, C.; van Moorselaar, D.; Foster, J. J.; Donk, M.; Theeuwes, J.
10.1101/2024.04.17.589855 — neuroscience — Posted on 2024-12-16
2598 ΔNP63 defines an exocrine-committed multipotent progenitor subset in the murine pancreas
Coolens, K.; Van der Vliet, M.; Van Campenhout, J.; del Pozo, N.; Torres-Cano, A.; Olson, C.; Xu, J.; Lickert, H.; Rovira, M.; Houbracken, I.; Baldan, J.; Real, F. X.; Spagnoli, F. M.; Rooman, I.
10.1101/2024.12.10.627728 — developmental biology — Posted on 2024-12-16
2602 Density dependence impedes evolutionary rescue
Olazcuaga, L.; Melbourne, B. A.; Nordstrom, S. W.; Hufbauer, R. A.
10.1101/2024.12.12.628101 — evolutionary biology — Posted on 2024-12-16
2603 Adaptation shapes the representational geometry in mouse V1 to efficiently encode the environment
Dipoppa, M.; Nogueira, R.; Bugeon, S.; Friedman, Y.; Reddy, C. B.; Harris, K. D.; Ringach, D. L.; Miller, K. D.; Carandini, M.; Fusi, S.
10.1101/2024.12.11.628035 — neuroscience — Posted on 2024-12-16
2604 Quantification of CAR T cell performance against acute myeloid leukemia using Bayesian inference
Shah, S.; Mueller, J.; Raatz, M.; Boettcher, S.; Traulsen, A.; Manz, M. M.; Altrock, P. M.
10.1101/2024.12.16.628628 — cancer biology — Posted on 2024-12-16
2606 Gasdermin D mediates a fast transient release of ATP after NLRP3 inflammasome activation before ninjurin 1-induced lytic cell death
Schachter, J.; Guijarro, A.; Angosto-Bazarra, D.; Pinilla, M.; Hurtado-Navarro, L.; Meunier, E.; Perez-Oliva, A. B.; Schwarzbaum, P. J.; Pelegrin, P.
10.1101/2024.12.10.627750 — immunology — Posted on 2024-12-16
2609 Structured light projection using image guide fibers for in situ photo-biofabrication
Chansoria, P.; Winkelbauer, M.; Zhang, S.; Janiak, J.; Liu, H.; Zenobi-Wong, M.
10.1101/2024.12.10.627729 — bioengineering — Posted on 2024-12-16
2612 Emergence of Candida auris in Minas Gerais, Brazil: Genomic Surveillance to inform Rapid Public Health Responses
Tome, L. M. R.; Camargo, D. R. A.; Bastos, R. W.; dos Santos, S. C. F.; Guimaraes, N. R.; Pedroso, S. H. S. P.; Silva, P. E. d. S. d.; Goes-Neto, A.; Figueredo, L. J. d. A.; Castro, G. d. C.; Rodrigues, A. M. R. N.; Cruzeiro, F. R. S.; Dutra, N. A. C.; Moura, J. B. P.; Pereira, G. d. C.; Faria, C. D.; Giovanetti, M.; Iani, F. C. d. M.; Alcantara, L. C. J.; Adelino, T. E. R.
10.1101/2024.12.13.627932 — genomics — Posted on 2024-12-16
2615 Genetic Diversity of Hippophae rhamnoides Varieties with Different Fruit Characteristics
Melnikova, N. V.; Arkhipov, A. A.; Zubarev, Y. A.; Novakovskiy, R. O.; Turba, A. A.; Pushkova, E. N.; Zhernova, D. A.; Mazina, A. S.; Dvorianinova, E. M.; Sigova, E. A.; Krasnov, G. S.; Ruan, C. J.; Borkhert, E. V.; Dmitriev, A. A.
10.1101/2024.12.10.627738 — genetics — Posted on 2024-12-16
2617 Experimental Warming Alters Nitrogen Cycle in a Humid Tropical Forest
Bartz, P. M.; Reed, S. C.; Grullon-Penkova, I. F.; Cavaleri, M. A.; Shahid, S.; Wood, T. E.; Bachelot, B.
10.1101/2024.12.10.627762 — ecology — Posted on 2024-12-16
2619 Identification of novel plasma proteomic biomarkers of Dupuytren Disease
Hummer, B.; Sebastiani, P. J.; Gurinovich, A.; Leshchyk, A.; Bager, C.; Karsdal, M.; Nielsen, S.; Eaton, C. J.
10.1101/2024.12.13.628406 — molecular biology — Posted on 2024-12-16
2622 Identification of Myeloid Protein Kinase C - Epsilon as a Novel Atheroprotective Gene
Wells, A. T.; Shen, M. M.; Binrouf, R. H.; D'Amico, A. E.; Bossardi Ramos, R.; Lennartz, M. R.
10.1101/2024.12.09.627650 — immunology — Posted on 2024-12-16
2623 A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers
Farina, S.; Cattabiani, A.; Mandge, D.; Shichkova, P.; Isbister, J. B.; Jacquemier, J.; King, J. G.; Markram, H.; Keller, D.
10.1101/2024.12.10.627740 — neuroscience — Posted on 2024-12-16
2624 Chronic High Intensity Interval Training (HIIT) exercise in adolescent rat's result in cocaine place aversion and ΔFosB induction
Thanos, P. K.; Hammond, N.; Rahman, N.; Zhan, S.; Gold, M. S.; Blum, K.; Quattrin, T.; Young Yim, Y.; Nestler, E.
10.1101/2024.12.10.627707 — neuroscience — Posted on 2024-12-16
2626 Evidence for reduced choroid plexus volume in the aged brain
Youh, R.-Y.; Perera, C.; Harrison, I. F.; Lythgoe, M. F.; Wright, D. K.; Nizari, S.; Wells, J. A.
10.1101/2024.12.11.627733 — neuroscience — Posted on 2024-12-16
2630 A Targeted Reference Database for Improved Analysis of Environmental 16S rRNA Oxford Nanopore Sequencing Data
Philip, M.; Nilsen, T.; Majaneva, S.; Pettersen, R.; Stokkan, M.; Ray, J. L.; Keeley, N.; Rudi, K.; Snipen, L.-G.
10.1101/2024.10.03.616456 — bioinformatics — Posted on 2024-12-16
2631 Octadecanoids as emerging lipid mediators in cnidarian-dinoflagellate symbiosis
Botana, M. T.; Lewis, R. E.; Quaranta, A.; Salamin, O.; Revol-Cavalier, J.; Oakley, C. A.; Feussner, I.; Hamberg, M.; Grossman, A. R.; Suggett, D. J.; Weis, V. M.; Wheelock, C. E.; Davy, S. K.
10.1101/2024.12.15.628472 — biochemistry — Posted on 2024-12-16
2633 Functional Imaging of Developing Brain in Mice and Non-Human Primates
ZHU, J.; He, D.; Sun, M.; Zheng, H.; Chen, Z.; Yang, J.; Lin, C.; Shi, Y. S.; SUN, L.; Qiu, Z.; Yuan, Q.
10.1101/2024.06.07.596778 — developmental biology — Posted on 2024-12-16
2634 Modelling low-dimensional interacting brain networks reveals organising principle in human cognition
Sanz Perl, Y.; Geli, S.; Perez-Ordoyo, E.; Zonca, L.; Idesis, S.; Vohryzek, J.; Jirsa, V. K.; Kringelbach, M. L.; Tagliazucchi, E.; Deco, G.
10.1101/2023.11.20.567824 — neuroscience — Posted on 2024-12-16
2635 Single-nucleus transcriptome atlas of orbitofrontal cortex in amyotrophic lateral sclerosis with a deep learning-based decoding of alternative polyadenylation mechanisms
McKeever, P. M.; Sababi, A. M.; Sharma, R.; Xu, Z.; Xiao, S.; McGoldrick, P.; Ketela, T.; Sato, C.; Moreno, D.; Visanji, N.; Kovacs, G. G.; Keith, J.; Zinman, L.; Rogaeva, E.; Goodarzi, H.; Bader, G.; Robertson, J.
10.1101/2023.12.22.573083 — neuroscience — Posted on 2024-12-16
2638 Highly expressed cell wall genes contribute to robustness of sepal size
Hartasanchez, D. A.; Dumond, M.; Dubrulle, N.; Moneger, F.; Boudaoud, A. A.
10.1101/2024.10.14.618238 — plant biology — Posted on 2024-12-16
2639 Melanoma Response to Immunotherapy is regulated by B Cell-Derived Extracellular Vesicles
Al Hrout, A.; Balayev, A.; Cervantes-Gracia, K.; Silina, K.; Levesque, M.; Chahwan, R.
10.1101/2024.12.12.628150 — cancer biology — Posted on 2024-12-16
2640 Specificity, length, and luck: How genes are prioritized by rare and common variant association studies
Spence, J. P.; Mostafavi, H.; Ota, M.; Milind, N.; Gjorgjieva, T.; Smith, C. J.; Simons, Y. B.; Sella, G.; Pritchard, J. K.
10.1101/2024.12.12.628073 — genomics — Posted on 2024-12-16
2641 From North to South: Transmission Dynamics of H1N1pdm09 Swine Influenza A Viruses in Italy
Giovanetti, M.; Cella, E.; Soliani, L.; Prosperi, A.; Mescoli, A.; Nucci, A.; della Ventura, C.; Junqueira, D. M.; Trovao, N. S.; Branda, F.; Carrera, M.; Lelli, D.; Rosignoli, C.; Faccini, S.; Fiorentini, L.; Guarneri, F.; Zehender, G.; Ciccozzi, M.; Chiapponi, C.; Moreno, A.
10.1101/2024.12.12.628126 — microbiology — Posted on 2024-12-16
2644 Early-life adversity mediates a thalamo-amgydalar circuit dysfunction underlying chronic pain and anxiety
Borruto, A. M.; Kohlund, T.; Renesse, M. v.; Rettig, L.; Leonhardt, N.; Calpe-Lopez, C.; Benn, L.; Friederich, H.-C.; Kuner, R.; Kuner, T.; Spanagel, R.; Wieland, S.
10.1101/2024.12.13.628438 — neuroscience — Posted on 2024-12-16
2645 Non-ionotropic signaling through the NMDA receptor GluN2B carboxy terminal domain drives morphological plasticity of dendritic spines and reverses fragile X phenotypes in mouse hippocampus
Barnes, S. A.; Thomazeau, A.; Finnie, P. S. B.; Heinrich, M. J.; Heynen, A. J.; Komiyama, N.; Grant, S. G. N.; Menniti, F. S.; Osterweil, E. K.; Bear, M. F.
10.1101/2024.12.15.628559 — neuroscience — Posted on 2024-12-16
2649 Inbreeding and demography interact to impact population recovery from bottlenecks
Zheng, J.; Rees-Baylis, E.; Janzen, T.; Zhang, Z.; Zhan, X.; Wang, D.; Li Richter, X.
10.1101/2024.12.10.627850 — ecology — Posted on 2024-12-15
2650 Diverse and Location-Specific Roles of PlexinA2, PlexinA4, and NCAM in Developing Hippocampal Mossy Fibers
Zhao, X.-F.; Kohen, R.; van Battum, E. Y.; Zeng, Y.; Zhang, X.; Johnson, C. N.; Wang, K.; Lim, B. C.; Oses-Prieto, J. A.; Rasband, J. M.; Burlingame, A. L.; Pasterkamp, R. J.; Rasband, M. N.; Giger, R. J.
10.1101/2024.12.15.628586 — developmental biology — Posted on 2024-12-16
2652 scSurv: a deep generative model for single-cell survival analysis
Mizukoshi, C.; Kojima, Y.; Hayashi, S.; Abe, K.; Kasugai, D.; Shimamura, T.
10.1101/2024.12.10.627659 — bioinformatics — Posted on 2024-12-15
2654 Genomic Insights into Hybridization and Speciation of Mitten Crabs in the Eriocheir Genus
Wang, C.; Wang, J.; Hou, X.; Chen, X.; Mandal, R. N.; Nusrat Hasan, K.; Yuan, C.; Luo, Y.
10.1101/2024.12.10.627874 — genomics — Posted on 2024-12-15
2655 Genomic divergence shaped the genetic regulation of meiotic homologous recombination in Brassica allopolyploids
PELE, A.; FALQUE, M.; LODE-TABUREL, M.; HUTEAU, V.; Morice, J.; CORITON, O.; Martin, O. C.; CHEVRE, A.-M.; ROUSSEAU-GUEUTIN, M.
10.1101/2024.12.10.627763 — genetics — Posted on 2024-12-15
2656 Assessment of DNA methylation from a single genomic region of ELOV2 is sufficient to predict chronological age
Zhu, B.; Li, D.; Han, G.; Yao, X.; Gu, H.; Liu, T.; Liu, L.; Dai, J.; Liu, I. Z.; Liang, Y.; Zheng, J.; Sun, Z.; Lin, H.; Wang, W.; Liu, N.; Yu, H.; Shi, M.; Shen, G.; Qu, L.
10.1101/2024.12.10.627662 — genetics — Posted on 2024-12-15
2661 Macrophage migration-dependent retraction fibers and migrasomes - a structural basis for spatiotemporal cytokine secretion.
Li, X.; Anbarlou, A.; Maste, V.; Condon, N. D.; Brown, D. L.; Shen, H.; Hsu, H.-R.; Ashraf, A.; Tan, S. J.; Wang, W.; Chernyavskiy, O.; Lucas, R. M.; Luo, L.; Koh, Y. W. H.; Murray, R. Z.; Lieschke, G. J.; Stow, J. L.
10.1101/2024.12.12.627632 — cell biology — Posted on 2024-12-15
2663 Use of Antibody Structural Information in Disease Prediction Models Reveals Antigen Specific B Cell Receptor Sequences in Bulk Repertoire Data
Nwogu, O.; Gill, K. K.; Moore, C.; Kroner, J. W.; Chang, W.-C.; Burkle, J.; Stevens, M. L.; Baatyrbek kyzy, A.; Miraldi, E. R.; Biagini, J. M.; Devonshire, A. L.; Kottyan, L.; Schwartz, J. T.; Assa'ad, A. H.; Martin, L. J.; Andorf, S.; Hershey, G. K. K.; Roskin, K. M.
10.1101/2024.12.10.627792 — immunology — Posted on 2024-12-15
2665 Assembly of a functional neuronal circuit in embryos of an ancestral metazoan is influenced by environmental signals including the microbiome
Noack, C.; Jenderny, S.; Giez, C.; Merza, O.; Hofacker, L.-M.; Wittlieb, J.; Repnik, U.; Bramkamp, M.; Ochs, K.; Bosch, T. C. G.
10.1101/2024.12.10.627692 — neuroscience — Posted on 2024-12-15
2666 Test-retest reliability of auditory MMN measured with OPM-MEG
Demko, L.; Iglesias, S.; Mellor, S.; Bassi, C.; Brand, K.; Kalberer, A.; Koechli, L.; Marino, S.; Zimmermann, N. D.; Heinzle, J.; Stephan, K. E.
10.1101/2024.12.10.627674 — neuroscience — Posted on 2024-12-15
2667 Targeted KRAS(G12V) degradation elicits efficient and durable lung adenocarcinoma regression in vivo
Martin, A.; Garcia-Perez, I. M.; San Jose, S.; Rojo, P.; Riego-Mejias, C.; Teodosio, C.; Barbosa, B. M.; Sanchez-Zarzalejo, C.; Folch-I-Casanovas, I.; Odena Caballol, A.; Jario, S.; Entrialgo, R.; Nokin, M.-J.; Loa, D.; Guruceaga, E.; Stephan-Otto Attolini, C.; Ambrogio, C.; Villanueva, A.; Vicent, S.; Riera, A.; Santamaria, D.; Mayor-Ruiz, C.
10.1101/2024.12.13.627539 — cancer biology — Posted on 2024-12-15
2670 The benefits of estradiol on cognitive aging in rats are independent from its effects on cardiometabolic health
Montanari, C.; Dong, E. L.; Srinivasan, S.; De Oliveira Leite, A. P.; Delarge, A. F.; Maroteaux, M. J.; Desmoulins, L. D.; Menon, R.; Walker, A. B.; Lindsey, S. H.; Zsombok, A.; Daniel, J. M.
10.1101/2024.12.10.627611 — animal behavior and cognition — Posted on 2024-12-15
2677 ProCyon: A multimodal foundation model for protein phenotypes
Queen, O.; Huang, Y.; Calef, R.; Giunchiglia, V.; Chen, T.; Dasoulas, G.; Tai, L.; Ektefaie, Y.; Noori, A.; Brown, J.; Cobley, T.; Hrovatin, K.; Hartvigsen, T.; Theis, F.; Pentelute, B. L.; Khurana, V.; Kellis, M.; Zitnik, M.
10.1101/2024.12.10.627665 — bioinformatics — Posted on 2024-12-15
2686 Graphene-polymer Nanofibers Enable Optically Induced Electrical Maturation in Stem Cell-Derived Cardiomyocytes and Brain Organoids
LaMontagne, E.; Gonzalez, G.; Vatsyayan, R.; Martin-Burgos, B.; Puppo, F.; Biagi, D.; Papes, F.; Dayeh, S. A.; Muotri, A. R.; Engler, A. J.
10.1101/2024.12.09.627640 — bioengineering — Posted on 2024-12-15
2687 Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
Copley, K. E.; Mauna, J. C.; Danielson, H.; Ngo, M.; Xie, L.; Smirnov, A.; Davis, M.; Mayne, L.; Linsenmeier, M.; Rubien, J. D.; Portz, B.; Lee, B. L.; Odeh, H. M.; Hallegger, M.; Ule, J.; Pasinelli, P.; Poon, Y.; Fawzi, N. L.; Black, B. E.; Donnelly, C. J.; Jensen, B. K.; Shorter, J.
10.1101/2024.12.14.628507 — biochemistry — Posted on 2024-12-15
2688 Octadecanoids as emerging lipid mediators in cnidarian-dinoflagellate symbiosis
Botana, M. T.; Lewis, R. E.; Quaranta, A.; Salamin, O.; Revol-Cavalier, J.; Oakley, C. A.; Feussner, I.; Hamberg, M.; Grossman, A. R.; Suggett, D. J.; Weis, V. M.; Wheelock, C. E.; Davy, S. K.
10.1101/2024.12.15.628472 — biochemistry — Posted on 2024-12-15
2690 An activation-based high throughput screen identifies caspase-10 inhibitors
Castellon, J. O.; Yeun, C.; Han, B.; Andrews, K. H.; Ofori, S.; Julio, A.; Boatner, L. M.; Palafox, M. F.; Damoiseaux, R.; Backus, K.
10.1101/2024.12.15.625925 — biochemistry — Posted on 2024-12-15
2691 Sex differences in pant-hoot vocalizations in wild Eastern chimpanzees
Holden, E.; Grund, C.; Eguma, R.; Samuni, L.; Zuberberbuehler, K.; Soldati, A.; Hobaiter, C.
10.1101/2024.12.14.628485 — animal behavior and cognition — Posted on 2024-12-15
2697 The rx3 gene contributes to the evolution of eye loss in the cavefish Astyanax mexicanus
Shennard, D.; Sifuentes-Romero, I.; Ambosie, R.; Abdelaziz, J.; Duboue, E. R.; Kowalko, J. E.
10.1101/2024.12.11.628050 — evolutionary biology — Posted on 2024-12-15
2699 Temperature-driven biogeography of marine giant viruses infecting the picoeukaryote Micromonas
Demory, D.; Endo, H.; Baudoux, A.-C.; Bigeard, E.; Grimsley, N.; Simon, N.; Ogata, H.; Weitz, J. S.
10.1101/2024.12.12.627685 — ecology — Posted on 2024-12-14
2700 demres: An R package to study time-varying demographic resilience
Louvrier, J.; Courtiol, A.; White, E. W.; Clark, A. T.; Benhaiem, S.; Radchuk, V.
10.1101/2024.12.10.627540 — ecology — Posted on 2024-12-15
2702 NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids
Meijer, H. A.; Hetherington, A.; Johnson, S.; Gallagher, R. L.; Hussein, I. N.; Rae, J. M.; Noordzij, T. E.; Kalamara, M.; Macartney, T. J.; Davidson, L.; Martin, D. M.; Davies, P.; Sonnen, K. F.; Murray, P.; Dale, J. K.
10.1101/2024.12.10.627712 — developmental biology — Posted on 2024-12-15
2703 The dual coding gene SLC35A4 protects against oxidative stress
Ajala, I.; Tiaiba, I.; Grondin, B.; Lipuma, D.; Jmii, S.; Benlyamani, H.; Cappadocia, L.; Vanderperre, B.
10.1101/2024.12.14.627418 — cell biology — Posted on 2024-12-15
2705 Profiling of yeast Saccharomyces cerevisiae mitochondrial AMPylome reveals a regulation of ATP synthase coupling trough subunit delta
Kucharczyk, R.; Panja, C.; Masanta, S.; Wiesyk, A.; Niedzwiecka, K.; Baranowska, E.; Cysewski, D.; Sipko, M.; Anielska-MAzur, A.; Malinowska, A.
10.1101/2024.12.14.628500 — molecular biology — Posted on 2024-12-15
2707 Identification of a Cluster of Benzene Activation Enzymes in a Strictly Anoxic Methanogenic Consortium
Toth, C. R. A.; Molenda, O.; Nesbo, C. L.; Luo, F.; Devine, C. E.; Chen, X. C.; Wu, K.; Xiao, J. Z.; Guo, S.; Bawa, N.; Flick, R.; Edwards, E. A.
10.1101/2024.12.15.628547 — microbiology — Posted on 2024-12-15
2708 Mechanistic Insights into Dengue Virus Inhibition by a Clinical Trial Compound NITD-688
Wang, Y.; Song, L.; Fernandes, L.; Wang, Y.-H.; Zou, J.; Franklin, S. J.; Hu, Y.; Palmer, L. K.; Yeung, J.; Barriga, D.; Russell, W. K.; Moquin, S. A.; Shi, P.-Y.; Skepper, C.; Xie, X.
10.1101/2024.12.15.628546 — microbiology — Posted on 2024-12-15
2709 The impact of probiotic supplementation with effective microorganisms on water and gut microbiome of the Common carp
Jakimowicz, M.; Suchocki, T.; Mielczarek, M.; Napora-Rutkowski, L.; Brzoza, A.; Kaminska-Gibas, T.; Szyda, J.
10.1101/2024.12.14.628491 — microbiology — Posted on 2024-12-15
2710 Memory-Phenotype Ly49+ CD8 T emerging from the thymus develop into two subsets with distinct immune functions
Laubreton, D.; Grau, M.; Malassigne, V.; Prieux, M.; Tomkowiak, M.; Vocanson, M.; Walzer, T.; Marvel, J.
10.1101/2024.12.10.627689 — immunology — Posted on 2024-12-15
2711 Dissecting origins of wiring specificity in dense cortical connectomes
Harth, P.; Udvary, D.; Boelts, J.; Baum, D.; Macke, J. H.; Hege, H.-C.; Oberlaender, M.
10.1101/2024.12.14.628490 — neuroscience — Posted on 2024-12-15
2715 Episodic slow breathing in mice markedly reduces fear responses
de Sousa Abreu, R. P.; Hoffman, A. N.; Bondarenko, E.; Pujols, R. E. B.; Huang, Y.; Fanselow, M. S.; Feldman, J. L.
10.1101/2024.12.09.627565 — neuroscience — Posted on 2024-12-15
2717 The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State
Coleman, C. R.; Shinozuka, K.; Tromm, R.; Dipasquale, O.; Kaelen, M.; Roseman, L.; Muthukumaraswamy, S. D.; Nutt, D.; Barnett, L.; Carhart-Harris, R.
10.1101/2024.12.09.627609 — neuroscience — Posted on 2024-12-15
2718 Computational Primitives for Cost-Benefit Decision-Making
Rakocevic, L. I.; Davila, L. D.; Heaton, C. N.; Beck, D. W.; Ibanez-Alcala, R. J.; Hossain, S. B.; Reyes, N. F.; Macias, A. Y.; Salcido, A. A.; Tyulmankov, D.; Batson, S. A.; Drammis, S. M.; Negishi, K.; Vara, P.; Giri, A.; Gutierrez, S. M.; Moschak, T. M.; Goosens, K. A.; Friedman, A.
10.1101/2024.12.09.627657 — neuroscience — Posted on 2024-12-15
2719 4-Phenylbutyric acid modulates Connexin 43 expression restricting murine-β-coronavirus infectivity and virus-induced demyelination
Kasle, G.; Sharma, M.; Kumar, S.; Das, P.; Das Sarma, S.; Koval, M.; Mahadevan, A.; Kenyon, L. C.; Das Sarma, J.
10.1101/2024.12.10.627737 — neuroscience — Posted on 2024-12-15
2722 Structures of the human adult muscle-type nicotinic receptor in resting and desensitised states
Li, A.; Pike, A. C. W.; Webster, R.; Maxwell, S.; Liu, W.-W.; Chi, G.; Palace, J.; Beeson, D.; Sauer, D. B.; Dong, Y. Y.
10.1101/2024.12.13.624530 — neuroscience — Posted on 2024-12-15
2723 Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: Implications for Parkinson disease pathogenesis
Menozzi, E.; Geiger, M.; Meslier, V.; Fierli, F.; Gilles, M.; Chau, K.-Y.; David, A.; Shahar Golan, R.; Famechon, A.; Koletsi, S.; Morabito, C.; Quinquis, B.; Pons, N.; Ehrlich, S. D.; Macnaughtan, J.; Almeida, M.; Schapira, A. H.
10.1101/2024.12.15.627490 — neuroscience — Posted on 2024-12-15
2726 Exposure to low doses of Batrachochytrium dendrobatidis reveals variation in resistance in the Critically Endangered southern corroboree frog
Davidson, M. J.; Berger, L.; Aquilina, A.; Poveda, M. H.; Guinto, D.; McFadden, M.; Gilbert, D.; Goodall, D.; Zenger, K. R.; Skerratt, L. F.; Kosch, T. A.
10.1101/2024.12.11.628040 — zoology — Posted on 2024-12-15
2728 Phylogeography and genetic structure of the steppe marmot (Marmota bobak Muller, 1776)
Brandler, O. V.; Tambovtseva, V. G.; Tukhbatullin, A. R.; Rumyantsev, V. Y.; Grachov, A. A.; Kapustina, S. Y.
10.1101/2024.12.12.628213 — zoology — Posted on 2024-12-15
2729 DNA barcoding of passerine birds at an ornithological crossroad reveals significant East-West genetic lineage divergence
Tehrani, S. J.; Rezazadeh, E.; Kakhki, N. A.; Nourani, L.; Ebadi, V.; Karimi, S.; Karami, M.; Ashouri, F.; Sarshar, A.; Gossmann, T. I.; Aliabadian, M.
10.1101/2024.12.12.628090 — zoology — Posted on 2024-12-15
2730 Mapping cell-cell fusion at single-cell resolution
Gardner, A. L.; Zheng, L.; Howland, K. K.; Saunders, A.; Ramirez, A.; Parker, P.; Iloegbunam, C.; Morgan, D.; Jost, T. A.; Brock, A.
10.1101/2024.12.11.627873 — systems biology — Posted on 2024-12-14
2732 Representation Learning of Human Disease Mechanisms for a Foundation Model in Rare and Common Diseases
Ravandi, B.; Mowrey, W. R.; Chatterjee, A.; Haddadi, P.; Abdelmessih, M.; Ding, W.; Lambden, S.; Ughetto, M.; Barrett, I.; Diethe, T.; Del Angel, G.; Eliassi-Rad, T.; Ricchiuto, P.
10.1101/2024.11.19.624381 — systems biology — Posted on 2024-12-15
2733 Nitrogen response and growth trajectory of sorghum CRISPR-Cas9 mutants using high-throughput phenotyping
Jin, H.; Park, A.; Sreedasyam, A.; Li, G.; Ge, Y.; Swaminathan, K.; Schmutz, J.; Clemente, T. E.; Schnable, J. C.; Yang, J.
10.1101/2024.12.13.624727 — plant biology — Posted on 2024-12-15
2735 Transcription factors associated with regulation of transcriptome in human thigh and calf muscles at baseline and after one week of disuse
Borzykh, A.; Makhnovskii, P.; Ponomarev, I.; Vepkhvadze, T.; Lednev, E.; Rukavishnikov, I.; Orlov, O.; Tomilovskaya, E.; Popov, D. V.
10.1101/2024.12.10.627667 — physiology — Posted on 2024-12-15
2736 Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis
Clift, C. L.; Blaser, M. C.; Bartoli-Leonard, F.; Schlotter, F.; Higashi, H.; Kuraoka, S.; Kasai, T.; Turner, M. E.; Pham, T.; Perez, K. A.; Robson, S.; Body, S. C.; Muehlschlegel, J. D.; Aikawa, M.; Singh, S. A.; Aikawa, E.
10.1101/2024.12.09.627613 — pathology — Posted on 2024-12-15
2737 Dominant RDH12-retinitis pigmentosa impairs photoreceptor development and cone function in retinal organoids
Mejecase, C.; Zhou, Y.; Owen, N.; Soro-Barrio, P.; Cheloni, R.; Nair, N.; Sarkar, H.; Toualbi, L.; Moosajee, M.
10.1101/2024.12.11.627489 — pathology — Posted on 2024-12-15
2742 HALO: Hierarchical Causal Modeling for Single Cell Multi-Omics Data
Mao, H.; Jia, M.; Di, M.; Valenzi, E.; Cai, X. T.; Lafyatis, R. A.; Zhang, K.; Benos, P. V.
10.1101/2022.10.17.512602 — bioinformatics — Posted on 2024-12-15
2744 Stronger bat predation and weaker environmental constraints predict longer moth tails
Rubin, J.; Campbell, C. J.; Carvalho, A. P. S.; St. Laurent, R. A.; Crespo, G. I.; Pierson, T. L.; Guralnick, R. P.; Kawahara, A. Y.
10.1101/2024.05.05.590753 — evolutionary biology — Posted on 2024-12-15
2746 Apical clathrin-coated pits control the location, timing, and scale of microvillar growth
Perkins, O. L.; Mulligan, A. G.; Krystofiak, E. S.; Nagarajan, R. N.; Peebles, K. E.; Meenderink, L. M.; Millis, B. A.; Tyska, M. J.
10.1101/2024.10.21.619431 — cell biology — Posted on 2024-12-15
2748 Context-dependent NMDA receptor dysfunction predicts seizure treatment in mice with human GluN1 variant
Venkatesan, S.; Nazarkina, D.; Sullivan, M. T.; Tan, Y.-F.; Qu, S.; Ramsey, A. J.; Lambe, E. K.
10.1101/2024.11.01.619946 — neuroscience — Posted on 2024-12-15
2751 MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles.
Peters, L.; Rakateli, L.; Huchzermeier, R.; Bonnin-Marquez, A.; Maas, S. L.; Lin, C.; Jans, A.; Geng, Y.; Gorter, A.; Gijbels, M.; Rensen, S.; Olinga, P.; Hendrikx, T.; Krawczyk, M.; Brisbois, M.; Jankowski, J.; Bidzhekov, K.; Weber, C.; Biessen, E. A. L.; Shiri-Sverdlov, R.; Houben, T.; Doering, Y.; Bartneck, M.; van der Vorst, E. P. C.
10.1101/2024.02.18.580792 — pathology — Posted on 2024-12-15
2752 I/σI vs {Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation
Fu, Z.; Geisbrecht, B. V.; Bouyain, S.; Dyda, F.; Chrzas, J. J.; Kandavelu, P.; Miller, D. J.; Wang, B.-C.
10.1101/2024.12.10.627855 — biophysics — Posted on 2024-12-15
2754 Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing
Glaus, A. N.; Brechet, M.; Swinnen, G.; Lebeigle, L.; Iwaszkiewicz, J.; Ambrosini, G.; Julca, I.; Zhang, J.; Roberts, R.; Iseli, C.; Guex, N.; Jimenez-Gomez, J. M.; Glover, N.; Martin, G. B.; Strickler, S. R.; Soyk, S.
10.1101/2024.01.29.577624 — genetics — Posted on 2024-12-15
2757 The role of specific phosphorylation patterns in the oligomerization of Tau-R4
Bressler, S. G.; Grunhaus, D.; Aviram, A.; Rudiger, S.; Hurevich, M.; Friedler, A.
10.1101/2024.12.14.628478 — biochemistry — Posted on 2024-12-15
2758 Efficient assembly of plant genomes: A case study with evolutionary implications in Ranunculus (Ranunculaceae)
Karbstein, K.; Choudhary, N.; Xie, T.; Tomasello, S.; Wagner, N. D.; Barke, B. H.; Paetzold, C.; Bradican, J. P.; Preick, M.; Himmelbach, A.; Stein, N.; Papantonis, A.; Irisarri, I.; de Vries, J.; Pucker, B.; Hoerandl, E.
10.1101/2023.08.08.552429 — genomics — Posted on 2024-12-15
2760 Disease-associated programming of cell memory in glycogen storage disorder type 1a
Sprecher, U.; Dsouza, J.; Mishra, K.; Muchtar, N.; Shalev, O.; Eliassaf, A.; Morshina, A.; Miliano, A. C.; Mithieux, G.; Rajas, F.; Avraham, S.; Castellani, F. M.; Kaufman, H.; Bergman, Y.; Garti, N.; Garti, S.; Linial, M.; Anikster, Y.; Kakhlon, O.; Weil, M.
10.1101/2023.02.20.529109 — cell biology — Posted on 2024-12-15
2761 A VLP vaccine platform comprising the core protein of hepatitis B virus with N-terminal antigen capture
Fatema, K.; Snowden, J. S.; Watson, A.; Sherry, L.; Ranson, N. A.; Rowlands, D.; Stonehouse, N. J.
10.1101/2024.06.07.597873 — molecular biology — Posted on 2024-12-15
2762 Social benefits of facial experssion in a cichlid fish: Testing the face concentration hypothesis
Satoh, S.; Fukuda, K.; Matsui, H.; Kawasaka, K.; Matsuo, S.; Banda, T.; Banda, T.; Kanbe, K.; Konno, A.; Takei, S.; Kohda, M.; Kutsukake, N.
10.1101/2024.10.17.618800 — animal behavior and cognition — Posted on 2024-12-15
2763 Synergistic reinforcement learning by cooperation of the cerebellum and basal ganglia
Yohida, T.; Sugino, H.; Yamamoto, H.; Tanno, S.; Tamura, M.; Igarashi, J.; Isomura, Y.; Hira, R.
10.1101/2024.07.12.603330 — neuroscience — Posted on 2024-12-15
2765 SPE-CZE-MS quantifies zeptomole concentrations ofphosphorylated peptides
Serrano, L. R.; Mellors, J. S.; Thompson, J. W.; Lancaster, N. M.; Robinson, M. L.; Overmyer, K. A.; Quarmby, S. T.; Coon, J. J.
10.1101/2024.12.07.627347 — systems biology — Posted on 2024-12-14
2766 Dark side of the honeymoon: reconstructing the Asian x European rose breeding history through the lens of genomics
Leroy, T.; Albert, E.; Thouroude, T.; Baudino, S.; Caissard, J.-C.; Chastellier, A.; Chameau, J.; Jeauffre, J.; Loubert, T.; Paramita, S. N.; Pernet, A.; Soufflet-Freslon, V.; Oghina-Pavie, C.; Foucher, F.; Oyant, L. H.-S.; Clotault, J.
10.1101/2023.06.22.546162 — genomics — Posted on 2024-12-14
2767 Non-canonical DNA in human and other ape telomere-to-telomere genomes
Smeds, L.; Kamali, K.; Kejnovska, I.; Kejnovsky, E.; Chiaromonte, F.; Makova, K. D.
10.1101/2024.09.02.610891 — genomics — Posted on 2024-12-14
2771 Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Jain, A.; Heremans, I.; Rademaker, G.; Detomasi, T.; Rohweder, P.; Anderson, D.; Zhang, J.; Hernandez, G.; Gupta, S.; von Linde, T.; Lange, M.; Spacci, M.; Citron, Y.; Olzmann, J.; Dawson, D.; Craik, C.; Bommer, G.; Perera, R. M.; Zoncu, R.
10.1101/2024.12.13.628212 — biochemistry — Posted on 2024-12-14
2772 YibN, a bona fide interactor of YidC with implications in membrane protein insertion and membrane lipid production
Zhao, Z.; Yamamoto, N.; Young, J.; Solis, N.; Fong, A.; Al-Seragi, M.; Kim, S.; Aoki, H.; Phanse, S.; Le, H.-T.; Overall, C.; Nishikawa, H.; Babu, M.; Nishiyama, K.-i.; Duong, F.
10.1101/2024.12.13.628402 — biochemistry — Posted on 2024-12-14
2773 The role of specific phosphorylation patterns in the oligomerization of Tau-R4
Bressler, S. G.; Grunhaus, D.; Aviram, A.; Rudiger, S.; Hurevich, M.; Friedler, A.
10.1101/2024.12.14.628478 — biochemistry — Posted on 2024-12-14
2776 Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease
Fontana, L.; Martinucci, P.; Amistadi, S.; FELIX, T.; MOMBLE, M.; TACHTSIDI, A.; CORRE, G.; Chalumeau, A.; Hardouin, G.; Martin, J.; Romano, O.; amendola, m.; Antoniou, P.; Miccio, A.
10.1101/2024.12.13.628398 — molecular biology — Posted on 2024-12-14
2777 MaAsLin 3: Refining and extending generalized multivariable linear models for meta-omic association discovery
Nickols, W. A.; Kuntz, T.; Shen, J.; Maharjan, S.; Mallick, H.; Franzosa, E.; Thompson, K.; Nearing, J.; Huttenhower, C.
10.1101/2024.12.13.628459 — microbiology — Posted on 2024-12-14
2778 Sp140L Is a Novel Herpesvirus Restriction Factor
Cable, J. M.; Wongwiwat, W.; Grabowski, J.; White, R. E.; Luftig, M. A.
10.1101/2024.12.13.628399 — microbiology — Posted on 2024-12-14
2779 Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization
Newson, J. P. M.; Gurtler, F.; Piffaretti, P.; Meyer, A.; Sintsova, A.; Barthel, M.; Steiger, Y.; McHugh, S. C.; Enz, U.; Alto, N. M.; Sunagawa, S.; Hardt, W.-D.
10.1101/2024.12.14.628483 — microbiology — Posted on 2024-12-14
2782 Engineering prolyl hydroxylase-dependent proteolysis enables the orthogonal control of hypoxia responses in plants
Shukla, V.; Iacopino, S.; Dalle Carbonare, L.; he, Y.; Del Chiaro, A.; Papachristodoulou, A.; Giuntoli, B.; Licausi, F.
10.1101/2024.12.13.628401 — synthetic biology — Posted on 2024-12-14
2783 Redox-dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells
Blacker, T. S.; Mistry, N.; Plotegher, N.; Westbrook, E. R.; Sewell, M. D. E.; Carroll, J.; Szabadkai, G.; Bain, A. J.; Duchen, M. R.
10.1101/2024.12.13.628382 — biochemistry — Posted on 2024-12-14
2784 Dynamics of β-cardiac myosin between the super-relaxed and disordered-relaxed states
Cail, R. C.; Baez-Cruz, F. A.; Winkelmann, D. A.; Goldman, Y. E.; Ostap, E. M.
10.1101/2024.12.14.628474 — biochemistry — Posted on 2024-12-14
2788 Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever
Srour, S.; ElGhazaly, M.; O'Connor, D.; Gibani, M. M.; Darton, T. C.; Pollard, A. J.; Collins, M. O.; Humphreys, D.
10.1101/2024.12.13.628371 — microbiology — Posted on 2024-12-14
2789 Rapid Sterilization of Clinical Apheresis Blood Products using Ultra-High Dose Rate Radiation
Melemenidis, S.; Nguyen, K. D.; Baraceros-Pineda, R.; Barclay, C. K.; Bautista, J.; Lau, H.; Ashraf, R. M.; Manjappa, R.; Dutt, S.; Soto, L. A.; Katila, N.; Lau, B.; Visvanathan, V.; Yu, A. S.; Surucu, M.; Skinner, L. B.; Engleman, E. G.; Loo, B. W.; Pham, T. D.
10.1101/2024.12.14.628469 — microbiology — Posted on 2024-12-14
2791 Maladaptation in cereal crop landraces following a soot-producing climate catastrophe
McLaughlin, C.; Shi, Y.; Viswanathan, V.; Sawers, R. J.; Kemanian, A.; Lasky, J. R.
10.1101/2024.05.18.594591 — evolutionary biology — Posted on 2024-12-14
2792 Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation
Sheriff, L.; Copland, A.; Lecky, D. A.; Done, R.; George, L. S.; Jennings, E. K.; Rouvray, S.; Elliot, T. A.; Jinks, E. S.; Pallan, L.; Bending, D.
10.1101/2024.06.06.597762 — immunology — Posted on 2024-12-14
2793 M102, a combined NRF2 and HSF-1 activator for neuroprotection in amyotrophic lateral sclerosis.
Shaw, P. J.; Keerie, A. F.; Martins, R. R.; Allen, C. F.; Bowden, K. M.; Al Mashadi, S.; Marlow, T.; Myszczynska, M.; Thakur, N.; Beal, S. N.; Shaw, A.; Suresh, S.; McKinnon, S.; Daniel, A.; Wells, T. R.; Kalfus, I. N.; Shan, N.; Ferraiuolo, L.; Mead, R. J.
10.1101/2024.12.08.627389 — neuroscience — Posted on 2024-12-14
2795 Testing the Tests: Using Connectome-Based Predictive Models to Reveal the Systems Standardized Tests and Clinical Symptoms Are Reflecting
Samardzija, A.; Shen, X.; Luo, W.; Greene, A. S.; Mehta, S.; Tokoglu, F.; Arora, J.; Woods, S.; Katz, R.; Sanacora, G.; Srihari, V. H.; Scheinost, D.; Constable, R. T.
10.1101/2024.10.24.619737 — neuroscience — Posted on 2024-12-14
2796 Pleiotropic function of Dlx5/6 in coordinating the development of mammalian vocal and auditory organs
Sanchez-Garrido, F.; Bouzerand, V.; Kaiser, M.; Chaumeton, C.; Fontaine, A.; Zikmund, T.; Kaiser, J.; Heude, E.
10.1101/2024.12.13.628362 — developmental biology — Posted on 2024-12-13
2797 Simultaneous Overexpression of Three Enzymes of Chloroplast Metabolism Fails to Improve CO2 Assimilation or Biomass.
Lemonnier, P.; Wall, S.; Gherli, H.; Moreno-Garcia, B.; Afamefule, C.; Lawson, T.; Raines, C. A.; Lopez-Calcagno, P. E.
10.1101/2024.12.11.627974 — plant biology — Posted on 2024-12-14
2798 Survival time and prognostic factors in dogs diagnosed with haemangiosarcoma in UK first opinion practice
Taylor, C.; Barry, G.; O'Neill, D.; Guillen, A.; Pickard Price, P.; Labadie, J.; Brodbelt, D.
10.1101/2024.12.07.627327 — pathology — Posted on 2024-12-14
2799 Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers
Govindarajan, M.; Mejia-Guerrero, S.; Chafe, S. C.; Khan, S.; Shi, W.; Waas, M.; Khoo, A.; Liu, L. Y.; Ignatchenko, V.; Principe, S.; Sepiashvili, L.; Tatari, N.; Venugopal, C.; Miletic, P.; Topley, M.; Grewal, S.; McKenna, D.; Sandi, M.-J.; Pham, N.-A.; Casey, A.; Kim, H.; Karamboulas, C.; Meens, J.; Bergqvist, P.; Silva, B.; Chan, P.; Cerna-Portillo, L.; Chin, J.; Rao-Bhatia, A.; Tsao, M.-S.; Khokha, R.; Su, S.; Xu, W.; Goldstein, D.; Ailles, L.; Stambolic, V.; Liu, F.-F.; Cummins, E.; Samudio, I.; Singh, S. K.; Kislinger, T.
10.1101/2024.12.11.627962 — cancer biology — Posted on 2024-12-14
2800 Long-read Transcriptomics of Caviid Gammaherpesvirus 1: Compiling a Comprehensive RNA Atlas
Boldogkoi, Z.; Torma, G.; Dörmo, A.; Fülöp, A.; Tombacz, D.; Mizik, M.; Pretory, A. M.; Lee, S.-C.; Toth, Z.
10.1101/2024.12.11.627975 — genomics — Posted on 2024-12-14
2803 Identification of Myeloid Protein Kinase C - Epsilon as a Novel Atheroprotective Gene
Binrouf, R. H.; D'Amico, A. E.; Lennartz, M. R.; Bossardi Ramos, R.; Shen, M. M.; Wells, A. T.
10.1101/2024.12.09.627650 — immunology — Posted on 2024-12-14
2807 Genomic signatures of island colonization in highly diverse primates
Colmonero-Costeira, I.; Guschanski, K.; Djalo, M. L.; Fernandes, N.; Camara, T.; Farh, K.; Kuderna, L. F. K.; Rogers, J.; Marques-Bonet, T.; Bruford, M. W.; Russo, I.-R.; Jensen, A.; Ferreira da Silva, M. J.
10.1101/2024.12.13.628324 — genomics — Posted on 2024-12-13
2808 Occurrence of the Humboldt Penguin (Spheniscus humboldti, Meyen, 1834) in El Ferrol Bay, Chimbote, Peru, and strategies for its conservation
Loayza-Aguilar, R. E.; Medina-Quezada, H.; Merino, F.; Saldana-Rojas, G. B.; Mendoza, S.; Olivos-Ramirez, G. E.
10.1101/2024.12.10.627413 — ecology — Posted on 2024-12-13
2809 Zinc is a Key Regulator of the Sperm-Specific K+ Channel (Slo3) Function
Andriani, R. T.; Pipatpolkai, T.; Miyata, H.; Ikawa, M.; Okamura, Y.; Kawai, T.
10.1101/2024.12.12.628223 — physiology — Posted on 2024-12-13
2810 Inferring gene-pathway associations from consolidated transcriptome datasets: an interactive gene network explorer for Tetrahymena thermophila
Bertagna, M. A.; Bright, L. J.; Ye, F.; Jiang, Y.-Y.; Pradhan, A.; Sarkar, D.; Kumar, S.; Gao, S.; Turkewitz, A. P.; Tsypin, L. M.
10.1101/2024.12.12.627356 — bioinformatics — Posted on 2024-12-13
2811 Sexual dimorphism in molecular profiles of resting human skeletal muscle and the response to acute exercise and endurance training
Dreher, S. I.; Goj, T.; von Toerne, C.; Hoene, M.; Irmler, M.; Ouni, M.; Jaehnert, M.; Beckers, J.; Hrabe de Angelis, M.; Peter, A.; Moller, A.; Birkenfeld, A. L.; Schuermann, A.; Hauck, S. M.; Weigert, C.
10.1101/2024.12.12.627717 — biochemistry — Posted on 2024-12-14
2812 Male Mice Have no Sugar-preference Behavior
Pan, T.; Huang, J.-F.; Wu, Q.-C.; Chen, Y.-X.; Li, X.-M.; Zhang, S.-G.; Pan, Y.-T.
10.1101/2024.12.11.627417 — animal behavior and cognition — Posted on 2024-12-13
2813 Comprehensive expression data for two honey bee species, Apis mellifera and Apis cerana japonica
Yokoi, K.; Hatakeyama, M.; Kuwasaki, S.; Maeda, T.; Yoshiyama, M.; Horigane-Ogihara, M.; Matsuyama, S.; Jouraku, A.; Bono, H.; Kimura, K.
10.1101/2024.12.11.627317 — genetics — Posted on 2024-12-13
2819 Peptide Information Compression Technology (PICT): A New Frontier in Therapeutic Peptide Discovery
Wang, H.; Wang, Z.-Y.; Jiang, W.-M.; Wang, Q.-Q.; Miao, L.; Wang, D.; Wang, H.-T.; Tung, S.-F.; Yang, J.-R.; Yang, B.; Liang, X.-B.; Li, Z.-W.; Wang, X.-P.; Zou, S.; He, F.; Guo, X.-T.; Yan, Y.; Xu, K.-M.; Wang, X.-Q.; Wang, X.-B.; Liu, H.-Q.; Li, X.-Q.
10.1101/2024.12.10.627447 — molecular biology — Posted on 2024-12-13
2823 A cysteine-rich domain of the Cuf1 transcription factor is required for high copper stress sensing and fungal virulence
Probst, C.; Denning-Jannace, C. A.; du Plooy, M.; Giamberardino, C. D.; Asfaw, Y.; Franz, K.; Alspaugh, J. A.
10.1101/2024.12.13.628380 — microbiology — Posted on 2024-12-13
2825 Multi-Omics Mapping of Gut Microbiota's Role in Progesterone Metabolism
Mong, G.-J. B.; Chen, M.-J.; Gicana, R. G.; Wang, H.-Y.; Li, C.-Y.; Wu, T.-Y.; Chou, C.-H.; Tu, Y.-A.; Chang, Y.-Y.; Lai, Y.-L.; Li, P.-T.; Tseng, Y.-L.; Hsiao, T.-H.; Chiang, Y.-R.
10.1101/2024.12.12.628284 — microbiology — Posted on 2024-12-13
2826 Engineering the Marine Pseudoalteromonas haloplanktis TAC125 via pMEGA Plasmid Targeted Curing Using PTasRNA Technology
Severino, A.; Lauro, C.; Calvanese, M.; Riccardi, C.; Colarusso, A.; Fondi, M.; Parrilli, E.; Tutino, M. L.
10.1101/2024.12.13.628325 — microbiology — Posted on 2024-12-13
2827 Encephalomyocarditis virus non-structural protein 2C degrades NDP52 autophagy protein to promote its own survival
Mo, R.; Cheng, R.; Dong, P.; Ma, T.; Zhang, Y.; Xie, J.; Li, S.; Li, H.; Idris, A.; Li, X.; Feng, R.
10.1101/2024.12.13.628388 — microbiology — Posted on 2024-12-13
2831 Altered Purinergic Signaling and CD8+ T Cell Dysregulation in STAT3 GOF Syndrome
Duran, J. S. C.; Sayed, S.; Dalalo, M. C.; Mauracher, A. A.; Knight, M. S.; Conrey, P. E.; Schultz, A. B.; Hay, C. A.; Lindell, R. B.; Howard, C. A.; Abrams, E. D.; Schmitt, E. G.; Thelin, M. A.; Bluestein, S.; Seroogy, C. M.; Pozos, T. C.; Thatayatikom, A.; Lundgren, I.; Gauthier, A.; Canna, S. W.; Su, H. C.; Keller, M. D.; Delmonte, O. M.; Satter, L. R. F.; Holland, S. M.; Bergerson, J. R. E.; Leiding, J. W.; Romberg, N.; Freeman, A. F.; Villarino, A. V.; Anderson, M. S.; Cooper, M. A.; Vogel, T. P.; Henrickson, S. E.
10.1101/2024.12.12.626682 — immunology — Posted on 2024-12-13
2832 Deconvoluting TCR-dependent & -independent activation is vital for reliable Ag-specific CD4+ T cell characterization by AIM assay
Zheng, M. Z. M.; Burmas, L.; Tan, H.-X.; Trieu, M.-C.; Lee, H. J.; Rawlinson, D.; Haque, A. P.; Kent, S. J.; Wheatley, A. K.; Juno, J. A.
10.1101/2024.12.10.627643 — immunology — Posted on 2024-12-13
2834 A role for fibroblast and mural cell subsets in models of neuropathic pain.
Villa-Hernandez, S.; Walker, J. V.; Hore, Z.; Fedele, L.; Zebochin, I.; Li, Y.; Davis, H.; Kanda, T.; Shimizu, F.; Taams, L.; Denk, F.
10.1101/2024.12.11.627455 — neuroscience — Posted on 2024-12-13
2837 IgDesign: In vitro validated antibody design against multiple therapeutic antigens using inverse folding
Shanehsazzadeh, A.; Alverio, J.; Kasun, G.; Levine, S.; Calman, I.; Khan, J. A.; Chung, C.; Diaz, N.; Luton, B. K.; Tarter, Y.; McCloskey, C.; Bateman, K. B.; Carter, H.; Chapman, D.; Consbruck, R.; Jaeger, A.; Kohnert, C.; Kopec-Belliveau, G.; Sutton, J. M.; Guo, Z.; Canales, G.; Ejan, K.; Marsh, E.; Ruelos, A.; Ripley, R.; Stoddard, B.; Caguiat, R.; Chapman, K.; Saunders, M.; Sharp, J.; Ganini da Silva, D.; Feltner, A.; Ripley, J.; Bryant, M. E.; Castillo, D.; Meier, J.; Stegmann, C. M.; Moran, K.; Lemke, C.; Abdulhaqq, S.; Klug, L. R.; Bachas, S.
10.1101/2023.12.08.570889 — synthetic biology — Posted on 2024-12-14
2839 A novel and robust method for assessing mitochondrial (dys)function in healthy and diseased frozen cardiac tissue
Hu, L.; van Rinsum, A.; Caliandro, R.; Qi, X.; Fan, S.; Jiang, X.; Massop, J.; Bekkenkamp-Grovenstein, M.; Ott, C.; Grune, T.; van de Wal, M. A. E.; Koopman, W. J. H.; Giesbers, M. J.; Gladka, M.; Keijer, J.; Zhang, D.
10.1101/2024.12.11.627239 — physiology — Posted on 2024-12-13
2841 Histopathological Evaluation of Pulmonary Arterial Remodeling in COVID-19
Gychka, S. G.; Nikolaienko, S. I.; Shults, N. V.; Vasylyk, V. M.; Pasichnyk, B. O.; Kagan, I. V.; Dibrova, Y. V.; Tuffaha, M.; Suzuki, Y. J.
10.1101/2024.12.12.628253 — pathology — Posted on 2024-12-13
2842 Galectin-1 Modulates Hepatocellular Carcinoma Response to Thermal Ablation Through Regulating Glycolysis
Nguyen, T.; Shin, Y.; Pham, J.; Ruppa, A.; Chen, P.-c.; Mirmohammadi, H.; Lu, D. S. K.; Raman, S. S.; Chiang, J.
10.1101/2024.12.12.628238 — cancer biology — Posted on 2024-12-13
2844 Probing nanomechanics by direct indentation using Nanoendoscopy-AFM reveals the nuclear elasticity transition in cancer cells
Ichikawa, T.; Kono, Y.; Kudo, M.; Shimi, T.; Miyashita, N.; Maesaka, T.; Ishibashi, K.; Yoshida, T.; Sivashanmugan, K.; Hanayama, R.; Hirata, E.; Miyata, K.; Kimura, H.; Fukuma, T.
10.1101/2024.12.13.626302 — biophysics — Posted on 2024-12-13
2845 Subtle changes at the RBD/hACE2 interface during SARS-CoV2 variant evolution: a molecular dynamics study
Gheeraert, A.; Leroux, V.; Mias-Lucquin, D.; Karami, Y.; Vuillon, L.; Chauvot de Bauchene, I.; Devignes, M.-D.; Rivalta, I.; Maigret, B.; Chaloin, L.
10.1101/2024.12.12.628120 — bioinformatics — Posted on 2024-12-13
2849 Deciphering Colorectal Cancer-Hepatocyte Interactions: A Multiomic Platform for Interrogation of Metabolic Crosstalk in the Liver-Tumor Microenvironment
Nelson, A. B.; Reese, L. E.; Rono, E.; Queathem, E. D.; Qiu, Y.; McCluskey, B. M.; Crampton, A.; Conniff, E.; Cummins, K.; Boytim, E.; Dansou, S.; Hwang, J.; Safo, S.; Puchalska, P.; Wood, D. K.; Schwertfeger, K. L.; Crawford, P. A.
10.1101/2024.12.06.627264 — bioinformatics — Posted on 2024-12-14
2852 Mitochondrial adenine base editing of mouse somatic tissues via adeno-associated viral delivery
Mutti, C. D.; Van Haute, L.; Luengo-Gutierrez, L.; Turner, K.; Silva-Pinheiro, P.; Minczuk, M.
10.1101/2024.12.10.627690 — bioengineering — Posted on 2024-12-13
2853 Generation of an inflammatory niche in a hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines
Meany, E. L.; Klich, J. H.; Jons, C. K.; Mao, T.; Chaudhary, N.; Utz, A.; Baillet, J.; Song, Y. E.; Saouaf, O. M.; Ou, B. S.; Williams, S. C.; Eckman, N.; Irvine, D. J.; Appel, E.
10.1101/2024.07.05.602305 — bioengineering — Posted on 2024-12-14
2854 H2B.W2, a Spermatocytes-specific Histone Variant, disrupts nucleosome stability and reduces chromatin compaction
NGUYEN, T. T.; Ding, D.; Bai, X.; Pang, M. Y. H.; Mingxi, D.; Liu, Y.; Jin, T.; Zhichun, X.; Zhang, Y.; Zhai, Y.; Yan, Y.; Ishibashi, T.
10.1101/2024.12.12.626759 — biochemistry — Posted on 2024-12-13
2856 Molecular mechanism of co-transcriptional H3K36 methylation by SETD2
Walshe, J. L.; Ochmann, M.; Neef, U.; Dybkov, O.; Dienemann, C.; Oberthuer, C.; Zheenbekova, A.; Urlaub, H.; Cramer, P.
10.1101/2024.12.13.628244 — biochemistry — Posted on 2024-12-13
2859 PEX1G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome
Sheedy, C. J.; Chowdhury, S. P.; Ali, B. A.; Miyamoto, J.; Pang, E. Z.; Bacal, J.; Tavasoli, K. U.; Richardson, C. D.; Gardner, B. M.
10.1101/2024.12.10.627778 — biochemistry — Posted on 2024-12-13
2860 Enzymatic epimerization of monoterpene indole alkaloids in Kratom
McDonald, A.; Nakamura, Y.; Schotte, C.; Lau, K.; Alam, R.; Lopes, A. A.; Buell, C. R.; O'Connor, S. E.
10.1101/2024.12.13.628308 — biochemistry — Posted on 2024-12-13
2862 Universal Study Design for Instrument Changes in Pharmaceutical Release Analytics
Ries, A. B.; Merkel, M. N.; Cossmann, K.; Paul, M.; Grunwald, R.; Klemmer, D.; Huebner, F.; Eggensperger, S.; Weiss, F. T.
10.1101/2024.12.11.627881 — biochemistry — Posted on 2024-12-13
2863 Expression screen of TNFR1 R347A, MyD88, IRAK4 death domains in E. coli followed by purification and biophysical characterization of TNFR1 R347A death domain
Przytulski, K.; Podkowka, A.; Tomczyk, T.; Gajewska, D.; Sypien, M.; Jelen, A.; Dahate, P.; Szlachcic, A.; Bista, M.; Walczak, M.
10.1101/2024.12.13.628329 — biochemistry — Posted on 2024-12-13
2866 Unveiling the evolutionary history of European vipers and their venoms from a multi-omic approach
Talavera, A.; Palmada-Flores, M.; Martinez-Freiria, F.; Mochales-Riano, G.; Burriel-Carranza, B.; Estarellas, M.; Fernandez-Guiberteau, D.; Camina, A.; Ursenbacher, S.; Vörös, J.; Halpern, B.; Pla, D.; Calvete, J. J.; Mikheyev, A. S.; Marques-Bonet, T.; Carranza, S.
10.1101/2024.12.10.627732 — genomics — Posted on 2024-12-13
2868 UniversalEPI: Harnessing Attention Mechanisms to Decode Chromatin Interactions in Rare and Unexplored Cell Types
Grover, A.; Zhang, L.; Muser, T.; Häfliger, S.; Wang, M.; Yates, J.; Van Allen, E.; Theis, F. J.; Ibarra, I. L.; Krymova, E.; Boeva, V.
10.1101/2024.11.22.624813 — genomics — Posted on 2024-12-14
2870 Morphological and Molecular Phylogenetic Characterization of Three New Marine Goniomonad Species
Phanprasert, Y.; Kim, S. Y.; Kang, N. S.; Jeong, M.; Kim, J. I.; Shin, W.; Lee, W. J.; Kim, E.
10.1101/2024.12.12.627435 — evolutionary biology — Posted on 2024-12-13
2871 Assessing coverage of the Monitoring Framework of the Kunming-Montreal Global Biodiversity Framework and opportunities to fill gaps.
Affinito, F.; Butchart, S. H. M.; Nicholson, E.; Hirsch, T.; Williams, J. M.; Campbell, J. E.; Ferrari, M. F.; Gabay, M.; Gorini, L.; Kalamujic Stroil, B.; Kohsaka, R.; Painter, B.; Pinto, J. C.; Scholz, A. H.; Straza, T. R. H.; Tshidada, N.; Vallecillo, S.; Widdicombe, S.; Gonzalez, A.
10.1101/2024.09.25.614896 — ecology — Posted on 2024-12-14
2873 The transcription factor TCF21 is necessary for adoption of cell fates by Foxd1+ stromal progenitors during kidney development
Finer, G.; Khan, M. D.; Zhou, Y.; Gadhvi, G.; Yacu, G. S.; Park, J.-S.; Gomez, R. A.; Sequeira-Lopez, M. L.; Quaggin, S. E.; Winter, D. R.
10.1101/2024.08.14.607910 — developmental biology — Posted on 2024-12-14
2874 Stu2 has an essential kinetochore role independent of regulating microtubule dynamics
Abouelghar, A. A.; Carrier, J. S.; Torvi, J. R.; Jenson, E.; Jones, C.; Gangadharan, B.; Geyer, E. A.; Rice, L.; Lagesse, B.; Barnes, G.; Miller, M. P.
10.1101/2022.09.09.507218 — cell biology — Posted on 2024-12-14
2875 Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome
Wang, J. Y.; Michki, N. S.; Sitaraman, S.; Banaschewski, B. J.; Jamal, R.; Gokey, J. J.; Lin, S. M.; Katzen, J. B.; Basil, M. C.; Cantu, E.; Kropski, J. A.; Zepp, J. A.; Frank, D. B.; Young, L. R.
10.1101/2023.06.17.545390 — cell biology — Posted on 2024-12-14
2877 Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows methylation is reset during stem cell reprogramming
Reed, X.; Weller, C. A.; Saez-Atienzar, S.; Beilina, A.; Solaiman, S.; Portley, M.; Kaileh, M.; Roy, R.; Ding, J.; Moore, A. Z.; Whitaker, D. T.; Traynor, B. J.; Gibbs, J. R.; Scholz, S. W.; Cookson, M. R.
10.1101/2024.12.13.627515 — molecular biology — Posted on 2024-12-13
2878 Structural determinants of inverted Alu-mediated backsplicing revealed by -MaP and -JuMP
Waldern, J. M.; Taylor, C.; Giannetti, C. A.; Irving, P. S.; Allen, S. R.; Zhu, M.; Backofen, R.; Mathews, D.; Weeks, K.; Laederach, A.
10.1101/2024.12.13.628372 — molecular biology — Posted on 2024-12-13
2880 Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference
Hvorecny, K. L.; Interlandi, G.; Veth, T. S.; Aprikian, P.; Manchenko, A.; Tchesnokova, V. L.; Dickinson, M. S.; Quispe, J. D.; Riley, N. M.; Klevit, R. E.; Magala, P.; Sokurenko, E.; Kollman, J. M.
10.1101/2024.12.06.627246 — immunology — Posted on 2024-12-14
2882 Multiscale Cloud-based Pipeline for Neuronal Electrophysiology Analysis and Visualization
Geng, J.; Voitiuk, K.; Parks, D. F.; Robbins, A.; Spaeth, A.; Sevetson, J. L.; Hernandez, S.; Schweiger, H. E.; Andrews, J. P.; Seiler, S. T.; Elliott, M. A. T.; Chang, E. F.; Nowakowski, T. J.; Currie, R.; Mostajo-Radji, M. A.; Haussler, D.; Sharf, T.; Salama, S. R.; Teodorescu, M.
10.1101/2024.11.14.623530 — neuroscience — Posted on 2024-12-14
2883 Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease
Li, Y.; Serras, C. P.; Blumenfeld, J.; Xie, M.; Hao, Y.; Deng, E.; Chun, Y. Y.; Holtzman, J.; An, A.; Yoon, S. Y.; Tang, X.; Rao, A.; Woldemariam, S.; Tang, A.; Zhang, A.; Simms, J.; Lo, I.; Oskotsky, T.; Keiser, M. J.; Huang, Y.; Sirota, M.
10.1101/2024.12.09.627436 — systems biology — Posted on 2024-12-13
2884 Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Reprogramming of Aortic Valve Cells Through STAT5
Cuevas, R. A.; Hortells, L.; Chu, C.; Wong, R.; Crane, A.; Boufford, C.; Regan, C.; Moorhead, W.; Bashline, M.; Parwal, A.; Parise, A.; Behzadi, P.; Gurkar, A.; Bruemmer, D.; Sembrat, J.; Sultan, I.; Gleason, T.; Billaud, M.; St. Hilaire, C.
10.1101/2022.08.23.504425 — pathology — Posted on 2024-12-14
2885 A diffusion model conditioned on compound bioactivity profiles for predicting high-content images
Cook, S.; Chyba, J.; Gresoro, L.; Quackenbush, D.; Qiu, M.; Kutchukian, P.; Martin, E.; Skewes-Cox, P.; Godinez, W. J.
10.1101/2024.10.10.616543 — bioinformatics — Posted on 2024-12-14
2886 Molecular determinants of Neu5Ac binding to tripartite ATP independent periplasmic (TRAP) transporter
Goyal, P.; Dhanabalan, K.; Scalise, M.; Friemann, R.; Indiveri, C.; Dobson, R. C.; Vinothkumar, K. R.; Subramanian, R.
10.1101/2024.03.29.587382 — biochemistry — Posted on 2024-12-14
2887 An orphan gene is essential for efficient sperm entry into eggs in Drosophila melanogaster
Guay, S. Y.; Patel, P. H.; Thomalla, J. M.; McDermott, K. L.; O'Toole, J. M.; Arnold, S. E.; Obrycki, S. J.; Wolfner, M. F.; Findlay, G. D.
10.1101/2024.08.08.607187 — genetics — Posted on 2024-12-14
2888 An age-specific burial practice reflected in ancient DNA preservation in Neolithic Catalhöyük
Kücükakdag Dogu, A.; Kücük Baloglu, F.; Chylenski, M.; Schotsmans, E. M. J.; Kılıc, M. S.; Vural, K. B.; Yüncü, E.; Kaptan, D.; Güler, M. N.; Yorulmaz, S.; Karabulut, N. B.; Saglıcan, E.; Kazancı, D. D.; Milella, M.; Marciniak, A.; Erdal, Y. S.; Pilloud, M. A.; Larsen, C. S.; Götherström, A.; Hodder, I.; Özer, F.; Haddow, S. D.; Knüsel, C. J.; Somel, M.
10.1101/2024.12.13.628343 — evolutionary biology — Posted on 2024-12-13
2889 Mathematically and biologically consistent framework for presence-absence pairwise indices
Sizling, A. L.; Keil, P.; Tjorve, E.; Tjorve, K. M. C.; Zarsky, J. D.; Storch, D.
10.1101/2021.07.14.452244 — ecology — Posted on 2024-12-14
2891 Thyroid hormones act as a timer for the postnatal maturation of parvalbumin neurons in mouse neocortex
Ren, J.; Markossian, S.; Guyot, R.; Aubert, D.; Brocard, J.; Wong, J.; Flamant, F.; Richard, S.
10.1101/2024.12.13.628336 — developmental biology — Posted on 2024-12-13
2893 Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding
Ocana-Santero, G.; Warming, H.; Munday, V.; MacKay, H. A.; Gibeily, C.; Hemingway, C.; Stacey, J. A.; Saha, A.; Lazarte, I. P.; Bachetta, A.; Deng, F.; Li, Y.; Packer, A. M.; Sharp, T.; Butt, S. J. B.
10.1101/2024.12.13.628340 — neuroscience — Posted on 2024-12-13
2894 GABA, Glutamate dynamics and BOLD observed during cognitive processing in psychosis patients with hallucinatory traits
Craven, A. R.; Dwyer, G.; Ersland, L.; Kazimierczak, K.; Lilleskare, L.; Noeske, R.; Sandoy, L. B.; Johnsen, E.; Hugdahl, K.
10.1101/2024.12.13.628297 — neuroscience — Posted on 2024-12-13
2896 Single neuron diversity supports area functional specialization along the visual cortical pathways
Feyerabend, M.; Pommer, S.; Jimenez-Sosa, M. S.; Rachel, J.; Sunstrum, J. K.; Preuss, F.; Mestern, S.; Hinkel, R.; Mietsch, M.; Viyajraghavan, S.; Everling, S.; Treue, S.; Arnsten, A. F.; Lewis, D. A.; Tripathy, S.; Gonzalez-Burgos, G.; Inoue, W.; Neef, A.; Staiger, J. F.; Martinez-Trujillo, J. C.
10.1101/2024.12.13.628359 — neuroscience — Posted on 2024-12-13
2897 A hybrid machine learning model for predicting gene expression from epigenetics across fungal species
Weinstock, L.; Schambach, J.; Fisher, A.; Kunstadt, C.; Lee, E.; Koning, E.; Morrell, W.; Davis, W.; Krishnakumar, R.
10.1101/2024.12.12.628183 — systems biology — Posted on 2024-12-13
2898 A novel Mannan-specific chimeric antigen receptor M-CAR redirects T cells to interact with Candida spp. hyphae and Rhizopus oryzae spores
Guimaraes, J. G.; de Campos, G. Y.; Machado, M. P.; Oliveira-Brito, P. K. M.; dos Reis, T. F.; Goldman, G.; Palma, P. V. B.; Fraga-Silva, T. F.; Cavallini, D. C. U.; Venturini, J.; da Silva, T. A.
10.1101/2024.12.12.628200 — bioengineering — Posted on 2024-12-13
2900 Data-driven synapse classification reveals a logic of glutamate receptor composition
Micheva, K. D.; Simhal, A. K.; Schardt, J.; Smith, S. J.; Weinberg, R. J.; Owen, S. F.
10.1101/2024.12.11.628056 — neuroscience — Posted on 2024-12-13
2901 E. coli transcription factors regulate promoter activity by a universal, homeostatic mechanism
Parisutham, V.; Guharajan, S.; Lian, M.; Rodgers, H.; Joyce, S.; Noto Guillen, M.; Brewster, R. C.
10.1101/2024.12.09.627516 — systems biology — Posted on 2024-12-13
2904 Disruption of the epigenetic regulator BAP1 drives chromatin remodeling leading to the emergence of cells with breast cancer stem cell properties and aberrant glycosylation.
Araujo, M. G. d. S.; Salle, A.; Cahais, V.; Renard, C.; Cuenin, C.; Poubel, C. P.; Keita, S.; Mosler, T.; Carreira, C.; Levy, G. G.; Parres, L.; Bourova-Flin, E.; Rousseaux, S.; Khochbin, S.; Ghantous, A.; Habazin, S.; Pucic-Bakovic, M.; Cosset, E.; Lauc, G.; Herceg, Z.; Khoueiry, R.
10.1101/2024.12.12.628129 — cancer biology — Posted on 2024-12-13
2910 Visible neural networks for multi-omics integration: a critical review
Selby, D. A.; Jakhmola, R.; Sprang, M.; Grossmann, G.; Raki, H.; Maani, N.; Pavliuk, D.; Ewald, J.; Vollmer, S. J.
10.1101/2024.12.09.627465 — bioinformatics — Posted on 2024-12-13
2911 Anti-fibrotic Effects of Atorvastatin Delivered via Keratin-based Hydrogels
Carroll, E. A.; Tarabokija, A. J.; Chaudhry, H.; Meer, A. S.; de Guzman, R. C.
10.1101/2024.12.09.627550 — bioengineering — Posted on 2024-12-13
2912 Tensions in tillage: Reduction in tillage intensity associates with lower wheat growth and nutritional grain quality despite enhanced soil biological indicators
Waibel, M.; Michel, J.; Antoine, M.; Balanzategui-Guijarro, I.; Cao, D.; Delaplace, P.; Le Gouis, J.; Alvarez, D.; Leon, C.; Manfroy, S.; Moya-Larano, J.; Perrochon, S.; Sanchez-Moreno, S.; Santin-Montanya, I.; Tenorio, J. L.; Thonar, C.; Vanderschuren, H.; Van Der Straeten, D.; Verlinde, T.; Weinmann, M.; Symanczik, S.
10.1101/2024.12.09.627503 — ecology — Posted on 2024-12-13
2913 Epigenetic reprogramming induced by Acetyl-CoA and SAM depletion is an evolutionarily-ancient path to malignant growth
Chen, Z.; Zhang, X.; Deng, M.; Li, C.; Nguyen, T. T.; Liu, M.; Dou, K.; Ishibashi, T.; Wang, J.; Yan, Y.
10.1101/2024.12.10.627655 — developmental biology — Posted on 2024-12-13
2914 A small molecule enhances arrestin-3 binding to the β2-adrenergic receptor
Kurt, H.; Akyol, A.; Son, C. D.; Zheng, C.; Gado, I.; Meli, M.; Ferrandi, E.; Bassanini, I.; Vasile, F.; Gurevich, V.; Nebol, A.; Cagavi, E.; Morra, G.; Sensoy, O.
10.1101/2024.12.12.628161 — cell biology — Posted on 2024-12-13
2916 Network-based amyloid-beta pathology predicts subsequent cognitive decline in cognitively normal older adults
He, H.; Razlighi, Q. R.; Gazes, Y.; Habeck, C.; Stern, Y.; the Alzheimer's Disease Neuroimaging Initiative,
10.1101/2024.12.10.627818 — neuroscience — Posted on 2024-12-13
2919 Hierarchical Patterns of Soil Biodiversity in the Atacama Desert: Insights Across Biological Scales
Villegas, L.; Pettrich, L.; Acevedo-Trejos, E.; Suwanngam, A.; Wassey, N.; Allende, M. L.; Stoll, A.; Holovachov, O.; Waldvogel, A.-M.; Schiffer, P. H.
10.1101/2024.09.30.615889 — ecology — Posted on 2024-12-13
2920 Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins
Inberg, S.; Iosilevskii, Y.; Calatayud-Sanchez, A.; Setty, H.; Oren-Suissa, M.; Krieg, M.; Podbilewicz, B.
10.1101/436758 — neuroscience — Posted on 2024-12-13
2922 Inter-individual gene expression variability implies stable regulation of brain-biased genes across organs
Bucao, C. F.; Aletti, C.; Moretti, S.; Thompson, A. W.; Racicot, B. L.; Wilson, C. A.; Bobe, J.; Braasch, I.; Guigen, Y.; Postlethwait, J. H.; Robinson-Rechavi, M.
10.1101/2024.11.11.623020 — evolutionary biology — Posted on 2024-12-13
2924 Environmental DNA vs. Community Science: Strengths and Limitations for Urban Odonata Surveys
Uche-Dike, R.; Tolman, E. R.; Benischek, C.; Schneider, M.; Kohli, M.; Bush, J.; Frandsen, P. B.; Errigo, I.; Frankel, W.; Gnojewski, K.; Chmura, K.; Jordan, D.; Kittler, H.; Liao, M.; Tobin, T.; Su, C.; Castillo, G.; Derdarian, E.; Wei, M.; Fernandez-Jaurez, S.; Tamano, T.; Gallafent, B.; Jenson, J.; Walser, C. A.; Ware, J. L.; Beatty, C. D.
10.1101/2024.11.26.625270 — ecology — Posted on 2024-12-13
2925 Large effect life-history genomic regions are associated with functional morphological traits in Atlantic salmon
Aykanat, T.; Debes, P. V.; Jansouz, S.; Gueguen, L.; House, A. H.; Ruokolainen, A.; Erkinaro, J.; Pritchard, V. L.; Primmer, C. R.; Bolstad, G. H.
10.1101/2024.12.05.627014 — ecology — Posted on 2024-12-13
2927 Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation
Isbister, J. B.; Ecker, A.; Pokorny, C.; Bolanos-Puchet, S.; Egas Santander, D.; Arnaudon, A.; Awile, O.; Barros-Zulaica, N.; Blanco Alonso, J.; Boci, E.; Chindemi, G.; Courcol, J.-D.; Damart, T.; Delemontex, T.; Dietz, A.; Ficarelli, G.; Gevaert, M.; Herttuainen, J.; Ivaska, G.; Ji, W.; Keller, D.; King, J.; Kumbhar, P.; Lapere, S.; Litvak, P.; Mandge, D.; Muller, E. B.; Pereira, F.; Planas, J.; Ranjan, R.; Reva, M.; Romani, A.; Rössert, C.; Schürmann, F.; Sood, V.; Teska, A.; Tuncel, A.; Van Geit, W.; Wolf, M.; Markram, H.; Ramaswamy, S.; Reimann, M. W.
10.1101/2023.05.17.541168 — neuroscience — Posted on 2024-12-13
2930 R-Loop control and mitochondria genome stability requires the 5'-3' exonuclease/flap-endonuclease OEX1
Schatz-Daas, D.; Le Blevenec, A.; Moratti, F.; Chung, K. P.; Mercier, P.; Iqbal, R. K.; Vallet, E.; Dietrich, A.; Bock, R.; Weber-Lotfi, F.; Gualberto, J. M.
10.1101/2024.11.05.621957 — plant biology — Posted on 2024-12-13
2933 Comparison of whole-genome assemblies of European river lamprey (Lampetra fluviatilis) and brook lamprey (Lampetra planeri)
Torresen, O. K.; Garmann-Aarhus, B.; Hoff, S. N. K.; Jentoft, S.; Svensson, M.; Schartum, E.; Tooming-Klunderud, A.; Skage, M.; Krabberod, A.; Vollestad, L. A.; Jakobsen, K. S.
10.1101/2024.12.06.627158 — genomics — Posted on 2024-12-13
2937 CRASH2p: Closed-loop Two Photon Imaging in a Freely Moving Animal
McNulty, P.; Wu, R.; Yamaguchi, A.; Heckscher, E. H.; Haas, A.; Nwankpa, A.; Skanata, M. M.; Gershow, M. H.
10.1101/2024.05.22.595209 — neuroscience — Posted on 2024-12-13
2938 SaprotHub: Making Protein Modeling Accessible to All Biologists
Su, J.; Li, Z.; Han, C.; Zhou, Y.; He, Y.; Shan, J.; Zhou, X.; Chang, X.; Jiang, S.; Ma, D.; The OPMC, ; Steinegger, M.; Ovchinnikov, S.; Yuan, F.
10.1101/2024.05.24.595648 — bioinformatics — Posted on 2024-12-13
2940 Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cell cultures
Wilson, A.; Kamel, W.; Davies, K.; De Laurent, Z. R.; Arif, R.; Bell-Sakyi, L.; Lamont, D.; Demyanenko, Y.; Noerenberg, M.; Kohl, A.; Mohammed, S.; Castello, A.; Brennan, B.
10.1101/2024.09.06.611624 — microbiology — Posted on 2024-12-13
2945 Monitoring in vivo transcription with synthetic serum markers
Watanabe, S.; Lee, S.; Harb, M.; Nouraein, S.; Raisley, E.; Li, H.; Buitrago, N. S.; Pforr, B.; Szablowski, J. O.
10.1101/2024.12.10.627810 — bioengineering — Posted on 2024-12-13
2946 Deep homology of a brachyury regulatory syntax and origin of the notochord
Fan, T.-P.; Lee, J.-R.; Lin, C.-Y.; Chen, Y.-C.; Cutting, A. E.; Cameron, R. A.; Yu, J.-K.; Su, Y.-H.
10.1101/2024.12.12.628285 — evolutionary biology — Posted on 2024-12-13
2948 Activity profiling of deubiquitinating inhibitors-bound to SARS-CoV-2 papain like protease with antiviral efficacy in murine infection model
Choudhary, S.; Nehul, S.; Nagaraj, S. K.; Narayan, R.; Verma, S.; Sharma, S.; Kumari, A.; Rani, R.; Saha, A.; Sircar, D.; Kaliappan, A.; Tripathi, S.; Sharma, G. K.; Kumar, P.; Tomar, S.
10.1101/2022.11.11.516107 — microbiology — Posted on 2024-12-13
2949 Make-or-break prime editing for bacterial genome engineering
Rengifo-Gonzalez, M.; Mazzuoli, M.-V.; Janssen, A. B.; Rueff, A.-S.; Burnier, J.; Liu, X.; Veening, J.-W.
10.1101/2024.06.27.601116 — microbiology — Posted on 2024-12-13
2950 2-oxoglutarate triggers assembly of active dodecameric Methanosarcina mazei glutamine synthetase
Herdering, E.; Reif-Trauttmansdorff, T.; Kumar, A.; Habenicht, T.; Hochberg, G.; Bohn, S.; Schuller, J.; Schmitz, R. A.
10.1101/2024.03.18.585516 — microbiology — Posted on 2024-12-13
2951 Constructed languages are processed by the same brain mechanisms as natural languages
Malik-Moraleda, S.; Taliaferro, M.; Shannon, S.; Jhingan, N.; Swords, S.; Peterson, D. J.; Frommer, P.; Okrand, M.; Sams, J.; Cardwell, R.; Freeman, C.; Fedorenko, E.
10.1101/2023.07.28.550667 — neuroscience — Posted on 2024-12-13
2960 Uncertainty in blacklisting potential Pacific plant invaders using species distribution models
Holle, V.; Rönnfeldt, A.; Schifferle, K.; Cabral, J. S.; Craven, D.; Knight, T.; Seebens, H.; Weigelt, P.; Zurell, D.
10.1101/2024.12.11.627501 — ecology — Posted on 2024-12-13
2962 Genes and pathways determining flowering time variation in temperate adapted sorghum
Mangal, H.; Linders, K.; Turkus, J.; Shrestha, N.; Long, B.; Kuang, X.; Cebert, E.; Torres-Rodriguez, J. V.; Schnable, J. C.
10.1101/2024.12.12.628249 — plant biology — Posted on 2024-12-13
2963 Integrative Omics reveals genetic basis and TaMYB7-A1's function in wheat WUE and drought resilience
Xiao, J.; Zhou, Y.; Wang, H.; Qiao, Y.; Zhao, P.; Cao, Y.; Liu, X.; Yang, Y.; Lin, X.; Xu, S.; Dong, B.; Wang, D.
10.1101/2024.12.12.628287 — plant biology — Posted on 2024-12-13
2965 A Dual-Functional Needle-Based VOC Sensing Platform for Rapid Vegetable Quality Examination
Hossain, O.; Wang, Y.; Li, M.; Jamalzadegan, S.; Mohammad, N.; Alireza, A.; Poonam, A. D.; Wei, Q.
10.1101/2024.12.12.628229 — plant biology — Posted on 2024-12-13
2966 Developmental rewiring of the NGAL/CUC/KLU network associated with pleiotropic roles of NGAL genes
Nicolas, A.; Papadopoulos, P.; Caroulle, M.; Adroher, B.; Goussot, M.; Sarthou, A.-S.; Arnaud, N.; Maugarny, A.; Laufs, P.
10.1101/2024.12.12.627899 — plant biology — Posted on 2024-12-13
2969 Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single-nucleus multiomics
Galvao, I. C.; Lemoine, M.; Kandratavicius, L.; Yasuda, C. L.; Alvim, M. K. M.; Ghizoni, E.; Blümcke, I.; Cendes, F.; Rogerio, F.; Lopes-Cendes, I.; Veiga, D. T.
10.1101/2024.12.12.628140 — neuroscience — Posted on 2024-12-12
2972 Deconstruction of a memory engram reveals distinct ensembles recruited at learning
Pouget, C.; Morier, F.; Treiber, N.; Garcia, P. F.; Mazza, N.; Zhang, R.; Reeves, I.; Winston, S.; Brimble, M. A.; Kim, C. K.; Vetere, G.
10.1101/2024.12.11.627894 — neuroscience — Posted on 2024-12-12
2975 A new pipeline SPICE identifies novel JUN-IKZF1 composite elements
Li, P.; Pulugulla, S. H.; Das, S.; Oh, J.; Spolski, R.; Lin, J.-X.; Leonard, W. J.
10.1101/2023.05.31.543110 — systems biology — Posted on 2024-12-12
2979 Disrupted callosal connectivity underlies long-lasting sensory-motor deficits in an NMDA receptor antibody encephalitis mouse model
Zhou, J.; Greenfield, A.; Loudermilk, R.; Bartley, C.; Chen, C.; Chen, X.; Leroux, M.; Lu, Y.; Necula, D.; Ngo, T.; Tran, B.; Honma, P.; Lauderdale, K.; Zhao, C.; Zhou, X.; Wang, H.; Nicoll, R.; Wang, C.; Paz, J.; Palop, J.; Wilson, M.; Pleasure, S.
10.1101/2022.09.29.510196 — neuroscience — Posted on 2024-12-12
2985 Caveolin-1 regulates context-dependent signaling and survival in Ewing Sarcoma.
Segal, D.; Wang, X.; Mazloom-Farsibaf, H.; Rajendran, D.; Butler, E.; Chen, B.; Chang, B.-J.; Ahuja, K.; Perny, A.; Bhatt, K.; Reed, D. K.; Castrillon, D.; Lee, J.; Jeffery, E.; Wang, L.; Nguyen, K.; Williams, N. S.; Rajaram, S.; Fiolka, R. P.; Jaqaman, K.; Skapek, S. X.; Hon, G. C.; Amatruda, J.; Danuser, G.
10.1101/2024.09.23.614468 — cancer biology — Posted on 2024-12-12
2986 Discovery of molecular glues that bind FKBP12 and novel targets using DNA-barcoded libraries
Zandi, T. A.; Romanowski, M. J.; Viscomi, J. S.; Tan, Z. Y.; Tong, B.; Bonazzi, S.; Zecri, F. J.; Schreiber, S. L.; Michaud, G. A.
10.1101/2024.12.09.627499 — biophysics — Posted on 2024-12-12
2992 Rapid Surge of Reassortant A(H1N1) Influenza Viruses in Danish Swine and their Zoonotic Potential
Ryt-Hansen, P.; George, S.; Hjulsager, C. K.; Trebbien, R.; Krog, J. S.; Ciucani, M. M.; Langerhuus, S. N.; DeBeauchamp, J.; Crumpton, J. C.; Hibler, T.; Webby, R.; Larsen, L. E.
10.1101/2024.12.11.627926 — genomics — Posted on 2024-12-12
2996 Machine Learning Models for Segmentation and Classification of Cyanobacterial Cells
Huffine, C. A.; Maas, Z. L.; Avramov, A.; Brininger, C.; Cameron, J. C.; Tay, J. W.
10.1101/2024.12.11.628068 — microbiology — Posted on 2024-12-12
2997 Vaccine-enhanced competition permits rational bacterial strain replacement in the gut
Lentsch, V.; Woller, A.; Rocker, A.; Aslani, S.; Moresi, C.; Ruoho, N.; Larsson, L.; Fattinger, S. A.; Wenner, N.; Cappio Barazzone, E.; Hardt, W.-D.; Loverdo, C.; Diard, M.; Slack, E.
10.1101/2022.07.20.498444 — microbiology — Posted on 2024-12-12
2998 Viral genomic features predict orthopoxvirus reservoir hosts
Tseng, K. K.; Koehler, H.; Becker, D. J.; Gibb, R.; Carlson, C. J.; Fernandez, M. d. P.; Seifert, S. N.
10.1101/2023.10.26.564211 — microbiology — Posted on 2024-12-12
2999 Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD mice
Bhuiyan, P.; Zhang, W.; Liang, G.; Jiang, B.; Vera, R.; Chae, R.; Kim, K.; Louis, L. S.; Wang, Y.; Liu, J.; Chuang, D.-M.; Wei, H.
10.1101/2024.09.18.613794 — neuroscience — Posted on 2024-12-12
3001 Mitochondrial DNA mutations in human oocytes undergo frequency-dependent selection but do not increase with age
Arbeithuber, B.; Anthony, K.; Higgins, B.; Oppelt, P.; Shebl, O.; Tiemann-Boege, I.; Chiaromonte, F.; Ebner, T.; Makova, K. D.
10.1101/2024.12.09.627454 — genomics — Posted on 2024-12-12
3002 Dynamic cell fate plasticity and tissue integration drive functional synovial joint regeneration
Blumenkrantz, M.; Woron, F.; Gagarin, E.; Weinstein, E.; Kamel, M. H.; Campos, L.; Geras, A.; Anderson, T.; Mo, J.; Sherwood, D.; Gwin, M.; Dumitrascu, B.; Chahine, N. O.; Smeeton, J.
10.1101/2024.12.12.628180 — developmental biology — Posted on 2024-12-12
3003 Hearing in Two Closely Related Peromyscus Species (Peromyscus maniculatus and P. leucopus)
Joseph, L.; New, E. M.; Joseph, D. M.; Woodley, T. C.; Franco, V. Y.; Li, B.-Z.; Wogan, G. O.; McCullagh, E. A.
10.1101/2024.12.09.627419 — neuroscience — Posted on 2024-12-12
3005 Engineering a ribozyme with aminoacyl-tRNA synthetase activity
Gan, G.; Chen, J.; Manuel, G.; Corn, R. M.; Luptak, A.; Golden, B.
10.1101/2024.12.12.627959 — biochemistry — Posted on 2024-12-12
3006 Multiscale single-cell assessment of the fibrotic niche in idiopathic pulmonary fibrosis
Liu, B.; Stewart, I.; May, J.; Zarcone, M. C.; Lopez-Jimenez, E.; Lambie, N.; Matthews, N.; Johnson, S. R.; Tatler, A. L.; Hewitt, R.; Wain, L. V.; Clifford, R. L.; Renzoni, E. A.; George, P. M.; Wells, A. U.; Reed, A. K.; Jenkins, R. G.; JOHN, A. E.
10.1101/2024.12.10.627749 — molecular biology — Posted on 2024-12-12
3007 High-Accuracy RNA Integrity Definition for Unbiased Transcriptome Comparisons with INDEGRA
Cleynen, A.; Ravindran, A.; Sethi, A.; Kumar, B.; Javaid, T.; Mahmud, S.; Woodward, K.; Vieira, H. G.; Anko, M. L.; Weatheritt, R. J.; Eyras, E.; Robin, S.; Shirokikh, N.
10.1101/2024.12.12.627949 — bioinformatics — Posted on 2024-12-12
3009 Conformational plasticity of human acid-sensing ion channel 1a
Cahill, J.; Hartfield, K. A.; Heusser, S. A.; Poulsen, M. H.; Yoshioka, C.; Pless, S. A.; Baconguis, I.
10.1101/2024.12.11.628012 — biochemistry — Posted on 2024-12-12
3011 Calmodulin binding is required for calcium mediated TRPA1 desensitization
Sanders, J. H.; Taiwo, K. M.; Adekanye, G. A.; Bali, A. P.; Zhang, Y.; Paulsen, C. E.
10.1101/2024.12.11.627969 — biochemistry — Posted on 2024-12-12
3012 A Distinct Autofluorescence Distribution Pattern Marks Enzymatic Deconstruction of Plant Cell Wall
Hossein Khani, S.; Ould Amer, K.; Remy, N.; Lebas, B.; Habrant, A.; Faraj, A.; Malandain, G.; Paës, G.; Refahi, Y.
10.1101/2024.12.12.628095 — biochemistry — Posted on 2024-12-12
3014 Mycobacterial EsxG·EsxH (TB9.8·TB10.4) peptides as a subunit vaccine to booster BCG vaccination in an experimental model of pulmonary Tuberculosis
Martinez-Olivares, C. E.; Lozano-Ordaz, V.; Mata-Espinosa, D.; Barrios-Payan, J. A.; Ortiz-Cabrera, A. E.; Rodriguez-Miguez, Y. R.; Hernandez-Pando, R.
10.1101/2024.12.12.628125 — biochemistry — Posted on 2024-12-12
3016 The multimerization pathway of the glucocorticoid receptor
Estebanez-Perpina, E.; Alegre-Marti, A.; Jimenez-Panizo, A.; Lafuente, A.; Johnson, T. A.; Montoya-Novoa, I.; Abella, M.; Perez, P.; Fernandez-Recio, J.; Presman, D. M.; Hager, G. L.; Fuentes-Prior, P.
10.1101/2024.12.12.628195 — biochemistry — Posted on 2024-12-12
3017 Long-read genomics reveal extensive nuclear-specific evolution and allele-specific expression in a dikaryotic fungus
Tam, R.; Moeller, M.; Luo, R.; Luo, Z.; Jones, A.; Periyannan, S.; Rathjen, J. P.; Schwessinger, B.
10.1101/2024.12.11.628074 — genomics — Posted on 2024-12-12
3019 Spatiotemporal dynamics of non-ecological speciation in rubyspot damselflies (Hetaerina spp.)
Patterson, C.; Brennan, A.; Cowling, H.; Gonzalez-Rodriguez, A.; Grether, G.; Mendoza Cuenca, L.; Springer, M.; Vega-Sanchez, Y.; Drury, J.
10.1101/2024.12.07.627243 — evolutionary biology — Posted on 2024-12-12
3022 Age-Related Patterns of DNA Methylation Changes
Chen, K. Y.; Wang, W.; Suryadevara, H. N. S. K.; Peng, G.
10.1101/2024.12.10.627727 — molecular biology — Posted on 2024-12-12
3026 spotPCR: A Rapid and Efficient Approach for Indexing Individual Template Molecules using Unique Molecular Identifiers
Limberis, J. D.; Nagel, R. J.; Chakravorty, S.; Block, D.; Dewell, S.; Nalyvayko, A.; Metcalfe, J. Z.
10.1101/2024.12.11.627791 — molecular biology — Posted on 2024-12-12
3027 Enhanced Yield and Gentle Purification of HIV for Cryo-Electron Tomography Analysis of Virion Maturation.
Preece, B.; Peppel, W.; Gallegos, R.; Yasassi, G.; Clinger, G.; Bohn, N.; Adhikary, B.; Mendonca, L.; Belnap, D.; Vershinin, M.; Saffarian, S.
10.1101/2024.12.12.628087 — microbiology — Posted on 2024-12-12
3029 The probability and duration of immigration in microbial communities
Curtis, T. P.; Allen, B.; Brown, M.; Bell, A.; Swan, D.; Davenport, R.; Sloan, W.
10.1101/2024.12.12.628136 — microbiology — Posted on 2024-12-12
3032 A novel membrane stress-response that blocks chromosomal replication by targeting the DnaA initiator via the ClpP protease
Saxena, R.; Gbolahan, A.; Li, T.; Saxena, R.; Wolcott, K.; Sohail, A.; Ahmed, I.; Chattoraj, D.; Crooke, E.
10.1101/2024.12.12.628197 — microbiology — Posted on 2024-12-12
3033 Salmonella Typhimurium Manipulates Syntaxin 7 to Navigate Endo-Lysosomal Trafficking in Host Cells
Vij, R.; Chatterjee, R.; NAIR, A. V.; Singh, A.; Hajra, D.; Gangi Setty, S. R.; Chakravortty, D.
10.1101/2024.12.12.628128 — microbiology — Posted on 2024-12-12
3036 Habitat filtering but not microbiota origin controls microbiome transplant outcomes in soil
Causevic, S.; Tackmann, J.; Sentchilo, V.; Malfertheiner, L.; von Mering, C.; van der Meer, J. R.
10.1101/2024.12.12.627922 — microbiology — Posted on 2024-12-12
3037 Vancomycin-resistant Enterococcus colonise the antibiotic-treated intestine by occupying distinct nutrient- and metabolite-defined intestinal niches
King, O. G.; Yip, A. Y. G.; Horrocks, V.; Miguens Blanco, J.; Marchesi, J. R.; Mullish, B. H.; Clarke, T. B.; McDonald, J. A. K.
10.1101/2024.12.12.628149 — microbiology — Posted on 2024-12-12
3039 Structural serology of polyclonal antibody responses to mRNA-1273 and NVX-CoV2373 COVID-19 vaccines
Bangaru, S.; Jackson, A. M.; Copps, J.; Fernandez-Quintero, M. L.; Torres, J. L.; Richey, S. T.; Nogal, B.; Sewall, L. M.; Torrents de la Pena, A.; Rehman, A.; Guebre-Xabier, M.; Girard, B.; Das, R.; Corbett-Helaire, K. S.; Seder, R. A.; Graham, B. S.; Edwards, D. K.; Patel, N.; Smith, G.; Ward, A. B.
10.1101/2024.12.11.628030 — immunology — Posted on 2024-12-12
3040 Deciphering Colorectal Cancer-Hepatocyte Interactions: A Multiomic Platform for Interrogation of Metabolic Crosstalk in the Liver-Tumor Microenvironment
Nelson, A. B.; Reese, L. E.; Rono, E.; Queathem, E. D.; Qiu, Y.; McCluskey, B. M.; Crampton, A.; Conniff, E.; Cummins, K.; Boytim, E.; Dansou, S.; Hwang, J.; Safo, S.; Puchalska, P.; Wood, D. K.; Schwertfeger, K. L.; Crawford, P. A.
10.1101/2024.12.06.627264 — bioinformatics — Posted on 2024-12-12
3041 A Label-free Nanowell-based Impedance Sensor for Ten-minute SARS-CoV-2 Detection
Meng, Z.; White, L.; Xie, P.; Mahmoodi, S. R.; Karapiperis, A.; Lin, H.; Drazer, G.; Javanmard, M.; DeMauro, E. P.
10.1101/2024.12.11.627986 — bioengineering — Posted on 2024-12-12
3044 Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference
Hvorecny, K. L.; Interlandi, G.; Veth, T. S.; Aprikian, P.; Manchenko, A.; Tchesnokova, V. L.; Dickinson, M. S.; Quispe, J. D.; Riley, N. M.; Klevit, R. E.; Magala, P.; sokurenko, e.; Kollman, J. M.
10.1101/2024.12.06.627246 — immunology — Posted on 2024-12-12
3046 Cross-sectional and longitudinal changes in category-selectivity in visual cortex following pediatric cortical resection
Liu, T. T.; Granovetter, M. C.; Maallo, A. M. S.; Robert, S.; Fu, J. Z.; Patterson, C.; Plaut, D.; Behrmann, M.
10.1101/2024.12.08.627367 — neuroscience — Posted on 2024-12-12
3048 SPE-CZE-MS quantifies zeptomole concentrations ofphosphorylated peptides
Serrano, L. R.; Mellors, J. S.; Thompson, J. W.; Lancaster, N. M.; Robinson, M. L.; Overmyer, K. A.; Quarmby, S. T.; Coon, J. J.
10.1101/2024.12.07.627347 — systems biology — Posted on 2024-12-12
3055 An AI-Cyborg System for Adaptive Intelligent Modulation of Organoid Maturation
Liu, R.; Ren, Z.; Zhang, X.; Li, Q.; Wang, W.; Lin, Z.; Lee, R.; Ding, J.; Li, N.; Liu, J.
10.1101/2024.12.07.627355 — bioengineering — Posted on 2024-12-12
3058 Simulating big mechanically-active culture systems (BigMACS) using paired biomechanics-histology FEA modelling to derive mechanobiology design relationships.
Schoenborn, S.; Yuan, M.; Fell, C. A.; Liu, C.; Fletcher, D. F.; Pirola, S.; Chan, H. F.; Woodruff, M. A.; Li, Z.; Toh, Y.-C.; Allenby, M. C.
10.1101/2024.12.08.627430 — bioengineering — Posted on 2024-12-12
3060 Vitrification and rapid rewarming of precision-cut liver slices for pharmacological and biomedical research
Ramesh, S.; Rao, J. S.; Namsrai, B.-E.; Fisher, B.; Tobolt, D.; Megaly, M.; Etheridge, M. L.; Pruett, T. L.; Seelig, D.; Murugan, P.; Aldaraiseh, B.; Finger, E. B.; Bischof, J. C.
10.1101/2024.12.08.627273 — bioengineering — Posted on 2024-12-12
3061 Rats pursue food and leisure following the same rational principles
Logue, R. S.; Garcia, A. K.; Bejarano, B. A.; Kendall, R. K.; Wikenheiser, A. M.
10.1101/2024.12.08.627420 — animal behavior and cognition — Posted on 2024-12-12
3063 Orchids, hawkmoths and Darwin revisited: How adaptation to pollination by hawkmoths spurred the speciation of Old and New World angraecoids
Farminhao, J. N.; Collobert, G.; Perez-Lamarque, B.; Verlynde, S.; Ramandimbisoa, B.; Kaymak, E.; Azandi, L.; Droissart, V.; Simo-Droissart, M.; Johnson, S.; Martos, F.; Stevart, T.
10.1101/2024.12.06.627257 — evolutionary biology — Posted on 2024-12-12
3067 Validating Atlantic salmon (Salmo Salar) scale reading by genetic parent assignment and PIT-tagging
Utne, K. R.; Brieuc, M. S. O.; Fjeldheim, P. T.; Urdal, K.; Ostborg, G. M.; Glover, K. A.; Harvey, A.; Skaala, O.
10.1101/2024.12.08.627404 — ecology — Posted on 2024-12-12
3068 Detection of bacteria through taste receptors primes the cellular immune response
Mazariegos, A. N.; Maniere, G.; Camp, D.; Khaul, R.; Duval, C. J.; Milleville, R.; Berthelot-Grosjean, M.; Alves, G.; Royet, J.; Grosjean, Y.; Musso, P.-y.; Tanentzapf, G.
10.1101/2024.09.26.615243 — immunology — Posted on 2024-12-12
3072 Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy
Ge, Q.; Yang, J.; Huang, F.; Dai, X.; Chen, C.; Guo, J.; Wang, M.; Zhu, M.; Shao, Y.; Xia, Y.; Zhou, Y.; Peng, J.; Deng, S.; Shi, J.; Hu, Y.; Zhang, H.; Wang, Y.; Wang, X.; Li, X.-M.; Chen, Z.; Shu, Y.; Zhu, J.-M.; Zhang, J.; Shen, Y.; Duan, S.; Xu, S.; Shen, L.; Chen, J.
10.1101/2024.12.07.627313 — neuroscience — Posted on 2024-12-12
3073 Behavioral and genetic markers of susceptibility to escalate fentanyl intake.
Keady, J.; Charnigo, R.; Shaykin, J. D.; Prantzalos, E.; Xia, M.; Denehy, E.; Bumgardner, C.; Miller, J.; Ortinski, P.; Bardo, M.; Turner, J. R.
10.1101/2024.12.06.627259 — neuroscience — Posted on 2024-12-12
3075 Goal-Directed Learning in Cortical Organoids
Robbins, A. S.; Schweiger, H. E.; Hernandez, S.; Spaeth, A.; Voitiuk, K.; Parks, D.; Van der Molen, T.; Geng, J.; Sharf, T.; Mostajo-Radji, M. A.; Haussler, D.; Teodorescu, M.
10.1101/2024.12.07.627350 — neuroscience — Posted on 2024-12-12
3080 Alteration of skin fibroblast steady state contributes to healing outcomes
Huang, Y.; Wang, N.; Xing, H.; Tian, J.; Zhang, D.; Gao, D.; Hsia, H. C.-h.; Lu, J.; Raredon, M. S. B.; Kyriakides, T.
10.1101/2024.12.06.627278 — pathology — Posted on 2024-12-12
3082 A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate
Brooks, E. R.; Moorman, A. R.; Bhattacharya, B.; Prudhomme, I. S.; Land, M.; Alcorn, H. L.; Sharma, R.; Pe'er, D.; Zallen, J. A.
10.1101/2024.08.25.609458 — developmental biology — Posted on 2024-12-12
3085 Modulation of all-trans retinoic acid by light and dopamine in the murine eye
Talwar, S.; Mazade, R.; Bentley-Ford, M.; Yu, J.; Pilli, N.; Kane, M. A.; Ethier, C. R.; Pardue, M. T.
10.1101/2024.12.06.627245 — systems biology — Posted on 2024-12-12
3086 Sex-related differences in vascular remodeling of sodium overloaded normotensive mice
Silva, J. C. d. S.; Viegas, K. A. d. S.; Lima, R. S. d.; Lima, C. T.; Peron, N. N.; Silva, M. B. d.; Irigoyen, M. C.; Lacchini, S.
10.1101/2024.07.09.602349 — physiology — Posted on 2024-12-12
3088 Seed dispersal disruption limits tropical forest regrowth
Fricke, E. C.; Cook-Patton, S. C.; Harvey, C. F.; Terrer, C.
10.1101/2024.12.06.627256 — ecology — Posted on 2024-12-12
3089 CD4 Co-Receptor Regulates Sex-Specific NK Cell Responses to Acute Toxoplasma gondii Infection.
Roy, T.; Bernstein, L.; Keplinger, H. K.; Fisk, K.; Ng, S. K.; Denton, S. L.; Gigley, J. P.
10.1101/2024.12.06.627254 — immunology — Posted on 2024-12-12
3092 Variant Set Distillation
Christ, R.; Kang, C. J.; Aslett, L.; Lam, D.; Savitski, M. F.; Stitziel, N. O.; Steinsaltz, D.; Hall, I.
10.1101/2024.12.06.627210 — genomics — Posted on 2024-12-12
3095 Cytotoxicity and Characterization of 3D-Printable Resins Using a Low-Cost Printer for Muscle-based Biohybrid Devices
Liao, A. S.; Dai, K.; Irez, A. B.; Sun, A.; Bennington, M. J.; Schaffer, S.; Chopra, B.; Seok, J. M.; Adams, R.; Zhang, Y. J.; Webster-Wood, V. A.
10.1101/2024.10.31.621115 — bioengineering — Posted on 2024-12-12
3097 An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation
Moore, G.; Revici, R.; Forbes-Beadle, L.; Birchenough, H. L.; Baldock, C.; Ashe, H. L.
10.1101/2024.07.08.602551 — developmental biology — Posted on 2024-12-12
3098 Evolution of drug-binding residues in eukaryotic ribosomes
Chan, L. I.; Ekemezie, C. L.; Brown, C. R.; Helena-Bueno, K.; Williams, T. A.; Melnikov, S. V.
10.1101/2024.11.28.625670 — microbiology — Posted on 2024-12-12
3099 HCF101 is a novel component of the CIA cytosolic iron-sulfur synthesis pathway in the human pathogen Toxoplasma gondii
Renaud, E. A.; Maupin, A. J.; Berry, L.; Bals, J.; Bordat, Y.; Demolombe, V.; Rofidal, V.; Vignols, F.; Besteiro, S.
10.1101/2024.05.01.592079 — microbiology — Posted on 2024-12-12
3102 Shared and distinct adaptations to early-life exercise training based on inborn fitness
Sadler, D. G.; Treas, L.; Barre, M.; Ross, T.; Sikes, J. D.; Zhong, Y.; Britton, S. L.; Koch, L.; Wankhade, U.; Borsheim, E.; Porter, C.
10.1101/2024.12.04.626895 — physiology — Posted on 2024-12-12
3103 CoREST Complex Inhibition Alters RNA Splicing to Promote Neoantigen Expression and Enhance Tumor Immunity
Fisher, R. J.; Park, K.; Lee, K.; Pinjusic, K.; Vanasse, A.; Ennis, C. S.; Ficcaro, S.; Marto, J.; Stransky, S.; Duke-Cohan, J.; Geethadevi, A.; Raabe, E. H.; Sidoli, S.; Hicks, C. W.; Keskin, D.; Wu, C. J.; Cole, P. A.; Alani, R. M.
10.1101/2024.12.12.627852 — cancer biology — Posted on 2024-12-12
3104 Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy Responses
Lei, J. T.; Dobrolecki, L. E.; Huang, C.; Srinivasan, R. R.; Vasaikar, S. V.; Lewis, A. N.; Sallas, C.; Zhao, N.; Cao, J.; Landua, J. D.; Moon, C. I.; Liao, Y.; Hilsenbeck, S. G.; Osborne, C. K.; Rimawi, M. F.; Ellis, M. J.; Petrosyan, V.; Wen, B.; Li, K.; Saltzman, A. B.; Jain, A.; Malovannaya, A.; Wulf, G. M.; Marangoni, E.; Li, S.; Kraushaar, D. C.; Wang, T.; Damodaran, S.; Zheng, X.; Meric-Bernstam, F.; Echeverria, G. V.; Anurag, M.; Chen, X.; Welm, B. E.; Welm, A. L.; Zhang, B.; Lewis, M. T.
10.1101/2024.12.09.627518 — cancer biology — Posted on 2024-12-12
3107 Cells Prioritize the Regulation of Cell Mass Density
Fu, J.; Ni, Q.; Wu, Y.; Gupta, A.; Ge, Z.; Yang, H.; Afrida, Y.; Barman, I.; Sun, S.
10.1101/2024.12.10.627803 — biophysics — Posted on 2024-12-12
3109 Evolution of drug-binding residues in bacterial ribosomes
Ekemezie, C. L.; Chan, L. I.; Brown, C. R.; Helena-Bueno, K.; Williams, T.; Melnikov, S. V.
10.1101/2024.10.31.621234 — evolutionary biology — Posted on 2024-12-12
3112 Neural mechanisms of credit assignment for delayed outcomes during contingent learning
Witkowski, P.; Rondot, L.; Kurth-Nelson, Z.; Garvert, M. M.; Dolan, R. J.; Behrens, T. E.; Boorman, E.
10.1101/2024.08.06.606895 — neuroscience — Posted on 2024-12-12
3113 Hormetic curve of dietary mono- and disaccharide content determines weight gain, gut microbiota composition and cognitive ability in mice
Bartochowski, P.; Chwastek, J.; Zglinicki, B.; Pietrzyk, O.; Olech-Kochanczyk, G.; Szewc, M.; Bartelik, A.; Torres, J. C.; Karpinski, A.; Jaholkowski, P.; Klejman, A.; Kochanczyk, M.; Bulska, E.; Galecka, M.; Kursa, M.; Konopka, A.; Kiryk, A.; Konopka, W.
10.1101/2024.12.06.625641 — neuroscience — Posted on 2024-12-12
3114 Engineering a Biosynthetic Pathway for the Production of (+)-Brevianamides A and B in Escherichia coli
Sandoval Hurtado, C. P.; Kelly, S. P.; Shende, V. V.; Perez, M.; Curtis, B.; Newmister, S. A.; Ott, K.; Pereira, F.; Sherman, D. H.
10.1101/2024.12.10.627567 — synthetic biology — Posted on 2024-12-12
3115 Tumor-Associated Macrophages in Meningiomas: An Independent Prognostic Factor for Poor Survival Outperforming the Benefits of T cells
Lotsch, C.; Liu, F.; Warta, R.; Jungwirth, G.; Rommel, C.; Barthel, M.; Lamszus, K.; Kessler, A. F.; Grabe, N.; Loehr, M.; Ketter, R.; Senft, C.; Westphal, M.; Sahm, F.; Krieg, S.; Unterberg, A.; Simon, M.; von Deimling, A.; Herold-Mende, C.
10.1101/2024.12.11.627726 — cancer biology — Posted on 2024-12-12
3116 Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia
Gordon, S. J.; Perner, F.; MacPherson, L.; Wenge, D. V.; Bourgeois, W.; Fennell, K. A.; Klaus, T.; Petrovic, J.; Horvath, J.; Cao, J.; Lapek, J.; Uryu, S.; White, J.; Lam, E. Y.; Mu, X. J.; Chan, Y.-C.; Gillespie, A.; Blyth, B.; Camerino, M. A.; Bozikis, Y. E.; Holze, H.; Knezevic, K.; Balic, J.; Stupple, P. A.; Street, I. P.; Monahan, B. J.; Sharma, S.; Wainwright, E. N.; Vassiliadis, D.; Paul, T. A.; Armstrong, S. A.; Dawson, M. A.
10.1101/2024.12.11.627663 — cancer biology — Posted on 2024-12-12
3117 Enhancer lncRNA LOC730338 limits the innate immune response against lymphoma cells, inhibiting ADAR2-dependent alternative transcription.
Cascione, L.; Guidetti, F.; Ramnarayanan, S.; Rinaldi, A.; Spriano, F.; Zadro, A.; Tarantelli, C.; Munz, N.; Arribas, A. J.; Johnson, R.; Bertoni, F.; Napoli, S.
10.1101/2024.12.10.627805 — cancer biology — Posted on 2024-12-12
3118 DNMT/G9a Complex Inhibition Uncovers Epigenetic Vulnerabilities and Induces IFN-Response in Acute Myeloid Leukemia
Schoenefeld, A.; Zanetti, C.; Schmitt, E. C.; Woods, K.; Westerback, A.; Mitsch, S. M.; Ruehle, F.; Kelekeci, S.; Fol, L.; Shah, V.; Sanchez-Saez, M.; Thevissen, S.; Schaeffer, A.; Schmits, U. R.; Sasca, D.; Kindler, T.; Woelfel, C.; Feuerstein-Akgoz, C.; Gerhaeuser, C.; Lutsik, P.; Riviere, J.; Hecker, J. S.; Goetze, K. S.; Platzbecker, U.; Echchannaoui, H.; Theobald, M.; Plass, C.; Padeken, J.; Medyouf, H.; Guezguez, B.
10.1101/2024.12.11.627891 — cancer biology — Posted on 2024-12-12
3119 Modernizing histopathological analysis: a fully automated workflow for the digital image analysis of the intestinal microcolony survival assay
Baikalov, A.; Wang, E.; Neill, D.; Shetty, N.; Waldrop, T.; Liu, K.; Delahousessaye, A.; Aguilar, E.; Mims, N.; Bartzsch, S.; Schueler, E.
10.1101/2024.12.09.627578 — cancer biology — Posted on 2024-12-12
3120 FAK modulates glioblastoma stem cell energetics via actomyosin contractility: regulation of glycolysis and mitochondrial function
Masalmeh, R. H. A.; Dawson, J. C.; Garcia, V. A.; Muir, M. T.; Carter, R. N.; Hardingham, G.; Davies, C.; Graham, R.; von Kriegsheim, A.; Marques Junior, J.; Pednekar, C.; Pollard, S. M.; Carragher, N. O.; Brunton, V. G.; Frame, M. C.
10.1101/2024.12.11.627900 — cancer biology — Posted on 2024-12-12
3121 Deciphering the tumor-infiltrating CD73+ regulatory gammadelta T cell ecosystem associated with poor survival of patients with ovarian cancer
LAFONT, V.; Chabab, G.; Michaud, H.-A.; Dejou, C.; Chauvin, M.; Chepeaux, L.-A.; Glasson, Y.; Boissiere, F.; Lenain, M.; Dume, A.-S.; Sarrant, P.; Chemin, G.; Wadja, P.; Dubois, B.; MacManus, A.; Colombo, P.-E.; Fabbro, M.; Bonnefoy, N.
10.1101/2024.12.09.627460 — cancer biology — Posted on 2024-12-12
3122 Single-cell multi-omic analysis of fibrolamellar carcinoma reveals rewired cell-to-cell communication patterns and unique vulnerabilities
Farghli, A. R.; Chan, M.; Sherman, M. S.; Dickerson, L. K.; Shui, B.; Nukaya, M.; Stephanou, A.; Ma, R. K.; Pepe-Mooney, B. J.; Smith, C. J.; Long, D.; Munn, P. R.; McNairn, A.; Grenier, J. K.; Karski, M.; Ronnekleiv-Kelly, S. M.; Pillarisetty, V. G.; Goessling, W.; Gujral, T.; Vakili, K.; Sethupathy, P.
10.1101/2024.12.11.627911 — cancer biology — Posted on 2024-12-12
3124 Preferential Release of microRNAs via Extracellular Vesicles is Associated with Ductal Carcinoma In Situ to Invasive Breast Cancer Progression
Elayapillai, S. P.; Dogra, S.; Lausen, J.; Bruns, M.; Behbod, F.; Hladik, C.; Gin, A.; Xu, C.; Zhang, R.; Ding, W.-Q.; Hannafon, B.
10.1101/2024.12.09.627283 — cancer biology — Posted on 2024-12-12
3125 Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression between patients
Smith, A. L.; Denny, N.; Chahrour, C.; Sharp, K.; Elliott, N.; Harman, J.; Jackson, T.; Geng, H.; Smith, O.; Bond, J.; Roberts, I.; Stam, R. W.; Crump, N. T.; Davies, J.; Roy, A.; Milne, T. A.
10.1101/2024.12.08.627394 — cancer biology — Posted on 2024-12-12
3126 Effective and Reliable Metrics to Select Crystal Diffraction Data
Fu, Z.; Geisbrecht, B. V.; Bouyain, S.; Dyda, F.; Chrzas, J. J.; Kandavelu, p.; Miller, D. J.; Wang, B.-C.
10.1101/2024.12.10.627855 — biophysics — Posted on 2024-12-12
3127 Regulatory interactions between APOBEC3B N- and C-terminal domains
Braza, K.; Demir, O.; Ahn, S.-H.; Morris, C.; Calvo-Tusell, C.; McGuire, K.; Carpenter, M.; Chen, Y.; de la Pena Avalos, B.; Casalino, L.; Aihara, H.; Harris, R. S.; Amaro, R. E.
10.1101/2024.12.11.628032 — biophysics — Posted on 2024-12-12
3129 ColBuilder: Flexible structure generation of crosslinked collagen fibrils
Monego, D.; Brosz, M.; Buck, J.; Viliuga, V.; Jung, J.; Stuehn, T.; Schmies, M.; Sugita, Y.; Gräter, F.
10.1101/2024.12.10.627782 — biophysics — Posted on 2024-12-12
3131 Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning
Sakai, Y.; Sen, S.; Sugihara, T.; Kakeyama, Y.; Iwasaki, M.; Schertler, G.; Deupi, X.; Koyanagi, M.; Terakita, A.
10.1101/2024.12.12.628111 — biophysics — Posted on 2024-12-12
3133 Recognizing amino acid sidechains in a medium resolution cryo-electron density map
Mondal, D.; Kumar, V.; Satler, T.; Ramachandran, R.; Saltzberg, D.; Chemmama, I.; Pilla, K. B.; Echeverria, I.; Webb, B. M.; Gupta, M.; Verba, K. A.; Sali, A.
10.1101/2024.12.10.627859 — biophysics — Posted on 2024-12-12
3135 RNA encodes physical information
Seim, I.; Zhang, V.; Jalihal, A. P.; Stormo, B. M.; Cole, S. J.; Ekena, J.; Nguyen, H. T.; Thirumalai, D.; Gladfelter, A. S.
10.1101/2024.12.11.627970 — biophysics — Posted on 2024-12-12
3138 Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody
Pinto Torres, J. E.; Claes, M.; Hendrickx, R.; Yuan, M.; Smiejkowska, N.; Van Wielendaele, P.; Hacisuleyman, A.; De Winter, H.; Muyldermans, S.; Michels, P. A. M.; Walkinshaw, M. D.; Versees, W.; Caljon, G.; Magez, S.; Sterckx, Y. G.- J.
10.1101/2024.06.14.598993 — biochemistry — Posted on 2024-12-12
3139 Comparative genomics of Rickettsiella bacteria reveal variable metabolic traits involved in symbiotic interactions with arthropods
Floriano, A. M. M.; El-Filali, A.; Amoros, J.; Buysse, M.; Jourdan-Pineau, H.; Sprong, H.; Kohl, R.; Dirks, R. P.; Schaap, P.; Koehorst, J.; Nijsse, B.; Bouchon, D.; Daubin, V.; Vavre, F.; Duron, O.
10.1101/2024.12.03.626579 — evolutionary biology — Posted on 2024-12-12
3142 Time-restricted feeding leads to sex- and organ-specific responses in the murine digestive system
Oparija-Rogenmozere, L.; Di Natale, M. R.; Hunne, B. L.; Koo, A.; Ringuet, M.; Fazio Coles, T. E.; Fothergill, L.; McQuade, R.; Furness, J. B.
10.1101/2024.02.20.580958 — molecular biology — Posted on 2024-12-12
3145 Essential Tremor Disrupts Rhythmic Brain Networks During Naturalistic Movement
West, T.; Steidel, K.; Flessner, T.; Calvano, A.; Kucukahmetler, D.; Stam, M.; Spedden, M.; Wahl, B.; Jousmaki, V.; Eraifej, J.; Oswal, A.; Saifee, T.; Barnes, G.; Farmer, S.; Pedrosa, D.; Cagnan, H.
10.1101/2024.06.26.600740 — neuroscience — Posted on 2024-12-12
3146 AKR1C mediates the acquired resistance to T-Dxd in a HER-2 positive gastric cancer line
wang, d.; huang, q.; wang, p.; tang, f.; han, y.; wang, x.; huang, j.; shi, l.; cao, w.; zhang, z.; gu, q.
10.1101/2024.12.11.627923 — cancer biology — Posted on 2024-12-12
3147 Secretome analysis of cancer-associated fibroblasts from prostate cancer to identify potential therapeutic targets
Abikar, A.; Mohammad, M. M. S.; Athalye, R. R.; Nadig, N.; Tamboli, N.; Babu, V.; Ramaiah, K.; Ranganathan, P.
10.1101/2024.12.09.627457 — cancer biology — Posted on 2024-12-12
3148 STAT1 Promotes PD-L1 Activation and Tumor Growth in Lymphangioleiomyomatosis
Olatoke, T.; Zhang, E. Y.; Wagner, A.; He, Q.; Li, S.; Astrinidis, A.; McCormack, F. X.; Xu, Y.; Yu, J. J.
10.1101/2024.12.11.627871 — cancer biology — Posted on 2024-12-12
3149 An NAMPT Inhibitor Decreases NAMPT Capture by an Antibody Directed against the 5-Phosphoribosyl-1-Pyrophosphate-Binding Loop: A Rational for an NAMPT Occupancy Assay
Shomali, M.; Hilairet, S.; Duhamel, M.; Nardi, F.; Bertrand, T.; Mathieu, M.; Arrebola, R.; Penarier, G.; Jegham, S.; Arigon, J.; Cosnier, S.; bouaboula, M.
10.1101/2024.12.11.628028 — cancer biology — Posted on 2024-12-12
3153 In silico biophysics and rheology of blood and red blood cells in Gaucher Disease
Chai, Z.; Li, G.; Ndour, P. A.; Connes, P.; Buffet, P. A.; Franco, M.; Karniadakis, G. E.
10.1101/2024.12.10.627687 — biophysics — Posted on 2024-12-12
3154 Discovery of molecular glues that bind FKBP12 and novel targets using DNA-barcoded libraries
Michaud, G. A.; Zandi, T. A.; Romanowski, M. J.; Viscomi, J. S.; Tan, Z. Y.; Tong, B.; Bonazzi, S.; Zecri, F. J.; Schreiber, S. L.
10.1101/2024.12.09.627499 — biophysics — Posted on 2024-12-12
3162 Sequence motif dynamics in RNA pools
Harth-Kitzerow, J.; Goeppel, T.; Burger, L.; Ensslin, T. A.; Gerland, U.
10.1101/2024.12.10.627702 — biophysics — Posted on 2024-12-12
3164 Oncogenic RAS Induces a Distinctive Form of Non-Canonical Autophagy Mediated by the P38-ULK1-PI4KB Axis
Ge, L.; Wang, X.; Li, S.; Lin, S.; Han, Y.; Zhan, T.; Huang, Z.; Wang, J.; Li, Y.; Deng, H.; Zhang, M.; Du, F.
10.1101/2024.12.10.627736 — cell biology — Posted on 2024-12-12
3165 Notch signaling stabilizes lengths of motile cilia in multiciliated cells in the lung
Guha, A.; Joy, N.; Deshpande, A.; Lingamallu, S. M.; Prabantu, V. M.; CN, N.; K, B.; Bhat, S.; Martinez, Z. A.; Livraghi-Butrico, A.; Hagood, J.; Boucher, R. C.; Lafkas, D.; Byrd, K. M.; Narayanan, S.; Shandil, R.
10.1101/2024.12.12.628112 — cell biology — Posted on 2024-12-12
3169 Reciprocal nutritional benefits in a sponge-seagrass association
Cardini, U.; Montilla, L. M.; Zapata-Hernandez, G.; Berlinghof, J.; Guarcini, E.; Furia, M.; Margiotta, F.; Meador, T.; Wild, C.; Fraschetti, S.; Olive, I.
10.1101/2024.12.06.627200 — ecology — Posted on 2024-12-12
3172 Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling
Lee, Y.; Ouyang, Q.; Riaz, H. A.; Ma, L.; Fleishman, M.; Schmidt, M.; Dupree, J. L.; Lambright, D. G.; Morrow, E. M.
10.1101/2024.12.09.627558 — cell biology — Posted on 2024-12-12
3175 Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis.
Kang, S. W. S.; Brown, L. A.; Miller, C. B.; Barrows, K. M.; Golino, J. L.; Cultraro, C. M.; Feliciano, D.; Cornelius-Muwanuzi, M. B.; Tran, A. D.; Kruhlak, M.; Lobanov, A.; Cam, M.; Porat-Shliom, N.
10.1101/2024.12.10.627730 — cell biology — Posted on 2024-12-12
3176 Survivin modulates stiffness-induced vascular smooth muscle cell motility
Mousso, T.; Rice, K.; Tumenbayar, B.-I.; Pham, K.; Heo, Y.; Heo, S. C.; Lee, K.; Lombardo, A. T.; Bae, Y.
10.1101/2024.12.11.628062 — cell biology — Posted on 2024-12-12
3177 5' HOXD Genes Differentially Regulate Gene Expression of Synovial Fibroblasts in Hand Joints
Mirrahimi, M.; Klein, K.; Calvo Cebrian, C.; Khmelevskaya, A.; Houtman, M.; Camarillo Retamosa, E.; Saadat, M. H.; Ezen, E.; Vogetseder, A.; Rothenfluh, E.; Berli, M.; Rauer, T.; Catanzaro, S.; Wang, J.; Andersson, J.; Distler, O.; Ospelt, C.
10.1101/2024.12.10.627720 — cell biology — Posted on 2024-12-12
3178 Rapamycin induced autophagy enhances lipid breakdown and ameliorates lipotoxicity in Atlantic salmon cells.
Phadwal, K.; Haggarty, J. H.; Kurian, D.; Marti, J. A.; Houston, R. D.; Betancor, M. B.; MacRae, V. E.; Whitfield, P. D.; Macqueen, D.
10.1101/2024.12.11.627915 — cell biology — Posted on 2024-12-12
3179 Quantification of morphological, functional, and biochemical features of H9c2 rat cardiomyoblast retinoic acid differentiation
York, N. S.; Rivera, J. E.; Manesh, M. R.; Lynes-Ford, K. W.; Smith, R.; Wicki-Stordeur, L. E.; Arbour, L. T.; Swayne, L. A.
10.1101/2024.12.10.627787 — cell biology — Posted on 2024-12-12
3181 GRASP55 Safeguards Proper Lysosome Function by Controlling Sorting of Lysosomal Enzymes at the Golgi
Nuechel, J.; Omidi, M.; Fernandes, S. A.; Tauber, M.; Pohl, S.; Plomann, M.; Demetriades, C.
10.1101/2024.12.10.627846 — cell biology — Posted on 2024-12-12
3185 Loom response in mouse superior colliculus depends on sensorimotor context
Zucca, S.; Schulz, A.; Goncalves, P. J.; Macke, J. H.; Saleem, A. B.; Solomon, S. G.
10.1101/2024.12.06.627189 — neuroscience — Posted on 2024-12-12
3189 inVAE: Conditionally invariant representation learning for generating multivariate single-cell reference maps
Aliee, H.; Kapl, F.; Pham, D.; Cakir, B.; Jimba, T.; Cranley, J.; Teichmann, S. A.; Meyer, K. B.; Vento-Tormo, R.; Theis, F. J.
10.1101/2024.12.06.627196 — bioinformatics — Posted on 2024-12-12
3190 Efficient High-Throughput DNA Breathing Features Generation Using Jax-EPBD
Inan, T. T.; Kabir, A.; Rasmussen, K.; Shehu, A.; Usheva, A.; Bishop, A.; Alexandrov, B. S.; Bhattarai, M.
10.1101/2024.12.06.627191 — bioinformatics — Posted on 2024-12-12
3192 Divergent regulatory element programs steer sex-specific supporting cell differentiation along mouse gonadal development
Stevant, I.; Abberbock, E.; Ridnik, M.; Weiss, R.; Swisa, L.; Futtner, C.; Maatouk, D.; Lovell-Badge, R.; Malysheva, V.; Gonen, N.
10.1101/2024.12.09.627451 — developmental biology — Posted on 2024-12-12
3197 A haplotype-resolved chromosomal reference genome for the porcini mushroom Boletus edulis
Brejon Lamartiniere, E.; Tremble, K.; Dentinger, B.; Dasmahapatra, K. K.; Hoffman, J. I.
10.1101/2024.12.09.627560 — evolutionary biology — Posted on 2024-12-12
3198 Pex3 promotes formation of peroxisome-peroxisome and peroxisome-lipid droplet contact sites
Amado, L.; Franzkoch, R.; Percifull, L.; Flatemersch, V.; Brüggermann, E. J.; Psathaki, O. E.; Schuldiner, M.; Bohnert, M.; Gonzalez Montoro, A.
10.1101/2024.12.10.627744 — cell biology — Posted on 2024-12-12
3200 Next generation sequencing identifies a pattern of novel germline variants in early-onset colorectal cancer
VANDE PERRE, P.; AL SAATI, A.; CABARROU, B.; PLENECASSAGNES, J.; GILHODES, J.; MONSELET, N.; LIGNON, N.; FILLERON, T.; VILLARZEL, C.; GOURDAIN, L.; SELVES, J.; MARTINEZ, M.; CHIPOULET, E.; COLLET, G.; MALLET, L.; BONNET, D.; GUIMBAUD, R.; Toulas, C.
10.1101/2024.12.09.627474 — genetics — Posted on 2024-12-12
3201 Lifespan Normative Models of White Matter Fractional Anisotropy: Applications to Early Psychosis
Cirstian, R.; Forde, N.; Zhang, G.; Hellemann, G. S.; Beckmann, C. F.; Kraguljac, N. V.; Marquand, A. F.
10.1101/2024.12.11.627897 — neuroscience — Posted on 2024-12-12
3203 Plant-induced transcriptional plasticity diverges between generalist and specialist herbivores
Wu, J.; Lin, Z.; Li, G.; Yu, W.; Zhang, Y.; Kou, Y.; Peng, P.; He, T.; Wang, Y.; Zhan, S.; Simon, J.-C.; Hogenhout, S. A.; Chen, Y.
10.1101/2024.12.07.627354 — plant biology — Posted on 2024-12-12
3205 Remarkable diversity of alkaloid scaffolds in Piper fimbriulatum
Damiani, T.; Smith, J.; Hebra, T.; Perkovic, M.; Cicak, M.; Kadlecova, A.; Rybka, V.; Dracinsky, M.; Pluskal, T.
10.1101/2024.12.10.627739 — plant biology — Posted on 2024-12-12
3207 FSTL3 is a biomarker of poor prognosis and is associated with immunotherapy resistance in ovarian cancer.
Chauvin, M.; Tromelin, E.; Roche-Prellezo, J.; Lancia, H. H.; Meinsohn, M.-C.; Coletti, C.; Nguyen, N. M. P.; Lafont, V.; Michaud, H.-A.; Mishra, R.; Gros, L.; Bonnefoy, N.; Pepin, D.
10.1101/2024.12.10.627747 — cancer biology — Posted on 2024-12-12
3209 PlateletBase: A Comprehensive Knowledgebase for Platelet Research and Disease Insights
Luo, H.; Wu, C.; Yu, S.; Ren, H.; Yin, X.; Zu, R.; Rao, L.; zhang, P.; Zhang, X.; Wu, R.; Leng, P.; Zhang, K.; Peng, Q.; Cao, B.; Qin, R.; Wei, H.; Qiao, J.; Xu, S.; Yi, Q.; Zhang, Y.; Huang, J.; Wang, D.
10.1101/2024.12.11.627883 — bioinformatics — Posted on 2024-12-12
3213 CellBinDB: A Large-Scale Multimodal Annotated Dataset for Cell Segmentation with Benchmarking of Universal Models
Shi, C.; Fan, J.; Deng, Z.; Liu, H.; Kang, Q.; Li, Y.; Guo, J.; Wang, J.; Gong, J.; Liao, S.; Chen, A.; Zhang, Y.; Li, M.
10.1101/2024.11.20.619750 — cell biology — Posted on 2024-12-12
3217 HippoMaps: Multiscale cartography of the human hippocampal formation
DeKraker, J.; Cabalo, D. G.; Royer, J.; Ngo, A.; Khan, A. R.; Karat, B.; Benkarim, O.; Rodriguez-Cruces, R.; Frauscher, B.; Pana, R.; Hansen, J. Y.; Misic, B.; Valk, S. L.; Lau, J. C.; Kirschner, M.; Bernasconi, A.; Bernasconi, N.; Muenzing, S.; Axer, M.; Amunts, K.; Evans, A. C.; Bernhardt, B. C.
10.1101/2024.02.23.581734 — neuroscience — Posted on 2024-12-12
3218 The visuomotor transformations underlying target-directed behavior
Zhao, P.; Tong, Y.; Lazarte, I. P.; Khan, B.; Tian, G.; Chen, K. K. Y.; Lam, T. K. C.; Hu, Y.; Semmelhack, J. L.
10.1101/2024.05.07.592863 — neuroscience — Posted on 2024-12-12
3223 Cytoplasmic calcium influx mediated by Lr14a regulates stomatal immunity against leaf rust in wheat
Yue, L.; Wang, L.; Neuhauser, B.; Zhang, S.; Herren, G.; Heuberger, M.; Jung, E.; Ludewig, U.; Zipfel, C.; Keller, B.
10.1101/2024.12.10.627212 — plant biology — Posted on 2024-12-12
3226 Jan and mini-Jan, a model system for potato functional genomics
Xin, H.; Strickland, L. W.; Hamilton, J. P.; Trusky, J. K.; Fang, C.; Butler, N. M.; Douches, D. S.; Buell, C. R.; Jiang, J.
10.1101/2024.12.10.627817 — plant biology — Posted on 2024-12-12
3227 Cold stress involves CBF dependent regulatory pathway to remodel wood formation in Eucalyptus gunnii hybrids.
Bachir, I. H.; Ployet, R.; San Clemente, H.; Aguilar, M.; Dupas, A.; Ladouce, N.; Martinez, Y.; Pettenati, J. G.; Teulieres, C.; Cassan-Wang, H.; Mounet, F.
10.1101/2024.12.11.627904 — plant biology — Posted on 2024-12-12
3228 Interfamily co-transfer of sensor and helper NLRs extends immune receptor functionality between angiosperms
Du, X.; Alam, M.; Witek, K.; Milnes, L.; Houghton, J.; Lin, X.; Zhang, Y.; Cui, F.; Sun, W.; Jones, J. D.; Guo, H.
10.1101/2024.12.11.627876 — plant biology — Posted on 2024-12-12
3229 Fe starvation induces a second LHCI tetramer to photosystem I in green algae
Liu, H. W.; Khera, R.; Grob, P.; Gallaher, S. D.; Purvine, S. O.; Nicora, C. D.; Lipton, M.; Niyogi, K. K.; Nogales, E.; Iwai, M.; Merchant, S.
10.1101/2024.12.11.624522 — plant biology — Posted on 2024-12-12
3230 RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples
Henikoff, S.; Zheng, Y.; Paranal, R. M.; Xu, Y.; Greene, J. E.; Henikoff, J. G.; Russell, Z. R.; Szulzewsky, F.; Thirimanne, H. N.; Kugel, S.; Holland, E. C.; Ahmad, K.
10.1101/2024.02.28.582647 — cancer biology — Posted on 2024-12-12
3231 Monitoring in vivo transcription with synthetic serum markers
Watanabe, S.; Lee, S.; Harb, M.; Nouraein, S.; Raisley, E.; Li, H.; Buitrago, N. S.; Pforr, B.; Szablowski, J. O.
10.1101/2024.12.10.627810 — bioengineering — Posted on 2024-12-12
3233 Meta-metabolome ecology reveals that geochemistry and microbial functional potential are linked to organic matter development across seven rivers
Danczak, R. E.; Goldman, A. E.; Borton, M. A.; Chu, R. K.; Toyoda, J. G.; Garayburu-Caruso, V. A.; Graham, E. B.; Morad, J. W.; Renteria, L.; Hager, J. R.; Arnon, S.; Brooks, S.; Bar-Zeev, E.; Jones, M.; Jones, N.; Lewandowski, J.; Meile, C.; Muller, B. M.; Schalles, J.; Schulz, H.; Ward, A.; Stegen, J. C.
10.1101/2024.01.10.575030 — ecology — Posted on 2024-12-12
3234 A conserved chronobiological complex times C. elegans development
Spangler, R. K.; Braun, K.; Ashley, G. E.; van der Does, M.; Wruck, D.; Ramos Coronado, A.; Ragle, J. M.; Iesmantavicius, V.; Morales-Moya, L. J.; Jonnalagadda, K.; Partch, C. L.; Grosshans, H.; Ward, J. D.
10.1101/2024.05.09.593322 — developmental biology — Posted on 2024-12-12
3235 Heat-Induced Phosphatidylserine Changes Drive HSPA1A's Plasma Membrane Localization
Low, J.; Altman, R.; Badolian, A.; Cuaresma, A. B.; Briseno, C.; Keshet, U.; Fiehn, O.; Stahelin, R. V.; Nikolaidis, N.
10.1101/2024.12.02.626454 — cell biology — Posted on 2024-12-12
3236 Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices
Adebowale, K.; Allan, C. J.; Ha, B.; Saraswathibhatla, A.; Zhu, J.; Indana, D.; Popescu, M.; Demirdjian, S.; Martinez, H. A.; Esclamado, A.; Yang, J.; Bassik, M. C.; Franck, C.; Bollyky, P.; Chaudhuri, O.
10.1101/2023.06.09.544394 — cell biology — Posted on 2024-12-12
3238 Effect of exportin 1/XPO1 nuclear export pathway inhibition on coronavirus replication.
Rahman, M. M.; Estifanos, B.; Glenn, H. L.; Gutierrez-Jensen, A. D.; Kibler, K. V.; Li, Y.; Jacobs, B. L.; McFadden, G.; Hogue, B. G.
10.1101/2023.02.09.527884 — microbiology — Posted on 2024-12-12
3239 Volatile Organic Compound Specialists in the Phycosphere
Padaki, V. G.; Mayali, X.; Weber, P.; Giovannoni, S.; Abraham, K.; Jacobs, K.; Collart, L.; Halsey, K.
10.1101/2024.06.14.599129 — microbiology — Posted on 2024-12-12
3240 Meta2DB: Curated Shotgun Metagenomic Feature Sets and Metadata for Health State Prediction
Kok, C. R.; Mulakken, N.; Thissen, J. B.; Manuel Marti, J.; Lee, R.; Trainer, J. B.; Goncalves, A.; Ranganathan, H.; Avila-Herrera, A.; Jaing, C.; Be, N. A.
10.1101/2024.10.03.616398 — microbiology — Posted on 2024-12-12
3241 Uncovering network mechanism underlying thalamic deep brain stimulation
Tian, Y.; Bello, E.; Crompton, D.; Paraskevopoulos, Z.; Kalia, S.; Hodaie, M.; Lozano, A. M.; Hutchison, W. D.; Johnson, M.; Popovic, M. R.; Milosevic, L.; Lankarany, M.
10.1101/2023.12.09.570924 — neuroscience — Posted on 2024-12-12
3242 Experience Alters the Timing Rules Governing Synaptic Plasticity and Learning
Jayabal, S.; Bhasin, B. J.; Kounga, M.; DiSanto, J.; Suvrathan, A.; Goldman, M. S.; Raymond, J. L.
10.1101/2022.11.28.518128 — neuroscience — Posted on 2024-12-12
3243 Details matter! Multimodal personalization increases the efficacy of transcranial direct current stimulation for modulation of sensorimotor integration
Radecke, J.-O.; Kuehn, A.; Erdbruegger, T.; Buschermoehle, Y.; Rashidi, S.; Stoeckler, H.; Sack, B.; Borgwardt, S.; Schneider, T. R.; Gross, J.; Wolters, C. H.; Sprenger, A.; Lencer, R.
10.1101/2024.11.06.622280 — neuroscience — Posted on 2024-12-12
3244 Individual Differences in Policy Precision: Links to Suicidal Ideation and Default Mode Network Dynamics
Yoon, D.; Kim, J.; Kim, D. H.; Shin, D. W.; Bong, S. H.; Kim, J.; Park, H.-j.; Jeon, H. J.; Jeong, B.
10.1101/2024.10.15.618415 — neuroscience — Posted on 2024-12-12
3245 Monosynaptic ventral tegmental area glutamate projections to the locus coeruleus enhance aversive processing
Parker, K. E.; Kuo, C.-C.; Buckley, A. R.; Patterson, A. P.; Duong, V.; Hunter, S. C.; McCall, J. G.
10.1101/2024.10.04.615025 — neuroscience — Posted on 2024-12-12
3247 Contextual Neural Dynamics During Time Perception in Primate Ventral Premotor Cortex
Diaz, H.; Bayones, L.; Alvarez, M.; Andrade-Ortega, B.; Valero, S.; Zainos, A.; Romo, R.; Rossi-Pool, R.
10.1101/2024.10.03.616577 — neuroscience — Posted on 2024-12-12
3251 Cancer immunotherapy response persists after lymph node resection
Zhou, H.; Menzel, L.; Baish, J. W.; O'Melia, M. J.; Darragh, L. B.; Specht, E.; Effiom, D. N.; Czapla, J.; Lei, P.-j.; Rajotte, J. J.; Liu, L.; Nikmaneshi, M. R.; Razavi, M. S.; Vander Heiden, M. G.; Ubellacker, J. M.; Munn, L. L.; Karam, S. D.; Boland, G. M.; Cohen, S.; Padera, T. P.
10.1101/2023.09.19.558262 — cancer biology — Posted on 2024-12-12
3252 DNA nanodevice for analysis of force-activated protein extension and interactions
Zhou, K.; Chung, M.; Cheng, J.; Powell, J. T.; Yan, Q.; Liu, J.; Xiong, Y.; Schwartz, M. A.; Lin, C.
10.1101/2024.10.25.620262 — biophysics — Posted on 2024-12-12
3253 Small-molecule modulators of lipid raft stability and protein-raft partitioning
Stefanski, K. M.; Huang, H.; Luu, D. D.; Hutchison, J. M.; Saksena, N.; Fisch, A. J.; Hasaka, T. P.; Bauer, J. A.; Kenworthy, A. K.; Van Horn, W. D.; Sanders, C.
10.1101/2024.10.28.620521 — biophysics — Posted on 2024-12-12
3254 Biocompatible Neodymium-Doped Nanocrystals as Probes for Diffraction-limited, in vitro Temperature Sensing
Bravo, M.; Yang, S.; Wen, D.; Krzyzowska, S.; Taemaitree, F.; Zaman, S.; Fortuni, B.; Rocha, S.; Mulvaney, P.; Uji-i, H.; Brooke, S.; Hutchison, J. A.
10.1101/2024.02.08.579538 — biophysics — Posted on 2024-12-12
3256 The Protein Language Visualizer: Sequence Similarity Networks for the Era of Language Models
Espinoza Herrera, J.; Manriquez Garcia, M. F.; Medina Bermejo, S.; Lopez Jasso, A.; Shi, K.; Mead, D.; Veskimägi, S. M.; O'Connor, M.; Siordia, A.; Roethler, N.; Jinich, A.
10.1101/2024.11.19.624229 — bioinformatics — Posted on 2024-12-12
3257 Rapid kinetics of H+ transport by membrane pyrophosphatase: evidence for a direct-coupling mechanism
Anashkin, V. A.; Bogachev, A. V.; Serebryakova, M. V.; Zavyalova, E. G.; Bertsova, Y. V.; Baykov, A. A.
10.1101/2024.12.06.627301 — biochemistry — Posted on 2024-12-11
3263 Road density simplifies regional food webs
Mestre, F.; Bastazini, V. A. G.; Ascensao, F.
10.1101/2024.03.07.583843 — ecology — Posted on 2024-12-12
3272 Criterion placement threatens the construct validity of neural measures of consciousness
Fahrenfort, J. J.; Johnson, P. A.; Kloosterman, N. A.; Stein, T.; van Gaal, S.
10.1101/2024.02.22.581517 — neuroscience — Posted on 2024-12-11
3274 Neural variability compresses with increasing belief precision during Bayesian inference
Skowron, A.; Kosciessa, J. Q.; Lorenz, R.; Hertwig, R.; van den Bos, W.; Garrett, D. D.
10.1101/2024.01.11.575180 — neuroscience — Posted on 2024-12-11
3276 High-Complexity Barcoded Rabies Virus for Scalable Circuit Mapping Using Single-Cell and Single-Nucleus Sequencing
Shin, D.; Urbanek, M. E.; Larson, H. H.; Moussa, A. J.; Lee, K. Y.; Baker, D. L.; Standen-Bloom, E.; Ramachandran, S.; Bogdanoff, D.; Cadwell, C. R.; Nowakowski, T. J.
10.1101/2024.10.01.616167 — neuroscience — Posted on 2024-12-11
3277 Improving anxiety research: novel approach to reveal trait anxiety through summary measures of multiple states
Varga, Z. K.; Pejtsik, D.; Toth, M.; Balogh, Z.; Aliczki, M.; Szente, L.; Balla, G. Y.; Kontra, L.; Eckert, Z.; Zsolt, B.; Mikics, E.
10.1101/2023.06.01.543235 — neuroscience — Posted on 2024-12-12
3281 A genome-wide association screen for genes affecting leaf trichome development and epidermal metal accumulation in Arabidopsis
Bezvoda, R.; Landeo-Rios, Y. M.; Kubatova, Z.; Kollarova, E.; Kulich, I.; Busch, W.; Zarsky, V.; Cvrckova, F.
10.1101/2024.09.10.612273 — plant biology — Posted on 2024-12-11
3284 Pipeline Olympics: continuable benchmarking of computational workflows for DNA methylation sequencing data against an experimental gold-standard
Lin, Y.-Y.; Breuer, K.; Weichenhan, D.; Lafrenz, P.; Wilk, A.; Chepeleva, M.; Muecke, O.; Schoenung, M.; Petermann, F.; Kensche, P.; Weiser, L.; Thommen, F.; Giacomelli, G.; Nordstroem, K.; Gonzalez-Avalos, E.; Merkel, A.; Kretzmer, H.; Fischer, J.; Kraemer, S.; Iskar, M.; Wolf, S.; Buchhalter, I.; Esteller, M.; Lawerenz, C.; Twardziok, S.; Zapatka, M.; Hovestadt, V.; Schlesner, M.; Schulz, M.; Hoffman, S.; Gerhauser, C.; Walter, J.; Hartmann, M.; Lipka, D.; Assenov, Y.; Bock, C.; Plass, C.; Toth, R.; Lutsik, P.
10.1101/2024.09.16.609142 — bioinformatics — Posted on 2024-12-11
3285 Old age variably impacts chimpanzee engagement and efficiency in stone tool use
Howard-Spink, E.; Matsuzawa, T.; Carvalho, S.; Hobaiter, C.; Almeida-Warren, K.; Gruber, T.; Biro, D.
10.1101/2024.11.25.625128 — animal behavior and cognition — Posted on 2024-12-11
3287 RegVelo: gene-regulatory-informed dynamics of single cells
Wang, W.; Hu, Z.; Weiler, P.; Mayes, S.; Lange, M.; Wang, J.; Xue, Z.; Sauka-Spengler, T.; Theis, F. J.
10.1101/2024.12.11.627935 — developmental biology — Posted on 2024-12-11
3288 Histones are exosome membrane proteins regulated by cell stress
Singh, B.; Sundbom, M. F.; Muthukrishnan, U.; Natarajan, B.; Stransky, S.; Nordin, J. Z.; Wiklander, O. P. B.; Sandblad, L.; Sidoli, S.; EL Andaloussi, S.; Haney, M.; Gilthorpe, J. D.
10.1101/2024.04.08.588575 — cell biology — Posted on 2024-12-11
3289 Mapping neuropeptide sigaling in the human brain
Ceballos, E. G.; Farahani, A.; Liu, Z.-Q.; Milisav, F.; Hansen, J. Y.; Dagher, A.; Misic, B.
10.1101/2024.12.11.627947 — neuroscience — Posted on 2024-12-11
3290 Sex-Specific Regulation of Behavioral Responses to Single Prolonged Stress: Role of PACAP
Smail, M. A.; Cotella, E. M.; Martelle, S. E.; Chambers, J. B.; Parikh, R. K.; Moore, C. E.; Packard, B. A.; Nawreen, N.; Moloney, R. D.; Herman, J. P.
10.1101/2024.12.11.627918 — neuroscience — Posted on 2024-12-11
3291 Serotonin system development and adult function are regulated by GDNF
Garton, D. R.; Runneberger, I.; Casserly, L.; Schorling, T.; Montano-Rodriguez, A. R.; Iivanainen, V.; Kopra, J. J.; Mätlik, K.; Fagerström-Billai, F.; Damdimopoulos, A.; Piepponen, T. P.; Andressoo, J.-O.
10.1101/2024.12.11.627811 — neuroscience — Posted on 2024-12-11
3292 Binge Feeding Promotes Appetite via Modulating Olfactory Flavor Representation
Lo, H.; Tantirigama, M. L. S.; Schoenherr, A.; Moreno-Velasquez, L.; Faiss, L.; Rost, B. R.; Larkum, M. E.; Judkewitz, B.; Stumpenhorst, K.; Rivalan, M.; Winter, Y.; Schmitz, D.; Johenning, F. W.
10.1101/2023.10.17.562714 — neuroscience — Posted on 2024-12-11
3295 Self-organizing human heart assembloids with autologous and developmentally relevant cardiac neural crest-derived tissues
Kostina, A.; Kiselev, A.; Huang, A.; Lankerd, H.; Caywood, S.; Jurado-Fernandez, A.; Volmert, B.; O'Hern, C.; Juhong, A.; Liu, Y.; Qiu, Z.; Park, S.; Aguirre, A.
10.1101/2024.12.11.627627 — bioengineering — Posted on 2024-12-11
3297 Ancestral aryl sulfatases in the alkaline phosphatase family allow for greater increases in catalytic efficiency than extant variants
Eenink, B.; Heberlein, M.; Holstein, J.; Lange, A. S.; Dilkaute, C.; Kaminski, T. S.; Bornberg-Bauer, E.; Jose, J.; Hollfelder, F.; van Loo, B.
10.1101/2024.12.10.627700 — evolutionary biology — Posted on 2024-12-11
3298 Gene flow can reveal ghost lineages
Tricou, T.; Marsot, E.; Boussau, B.; Tannier, E.; de Vienne, D. M.
10.1101/2024.12.11.627931 — evolutionary biology — Posted on 2024-12-11
3299 Activation of the ChvG-ChvI pathway promotes multiple survival strategies during cell wall stress in Agrobacterium tumefaciens
Bouchier, J. M.; Knebel, E.; Amstutz, J.; Torrens, G.; Santiago-Collazo, G.; McCurry, C.; Weisburg, A. J.; Cava, F.; Brown, P. J.
10.1101/2024.12.10.627833 — microbiology — Posted on 2024-12-11
3302 Oligomerization of PRMT1 Regulated RNA-Binding Protein Cascade Promotes Pancreatic Ductal Adenocarcinoma
Ru, Y.; Zhou, X.; Wang, X.; Sun, W.; He, Y.; Hu, G.; Li, W.; Hu, D.; Jiang, M.; Su, Z.; Niu, F.; Chen, G.; Zeng, J.; Sui, S.; Liu, W.; Li, Y.; Chen, S.
10.1101/2024.12.10.627716 — biochemistry — Posted on 2024-12-11
3304 Accurate in silico predictions of modified RNA interactions to a prototypical RNA-binding protein with {lambda}-dynamics
Angelo, M.; Bhargava, Y.; Kierzek, E.; Kierzek, R.; Hayes, R.; Zhang, W.; Vilseck, J. Z.; Aoki, S. T.
10.1101/2024.12.10.627848 — biochemistry — Posted on 2024-12-11
3306 Evolution of Salmonella Chromosomes and Its Influence on Gene Expression and Chromosomal Conformation
Hu, Y.; Chen, Z.; Sokaribo, A. S.; Zhao, Z.; Cao, X.; Zhang, J.; Liu, S.; Chen, R.; Deng, Y.; Bao, H.; Hui, X.; Sun, M.-a.; Zhu, G.; Liu, S.-L.; White, A. P.; Wang, Y.
10.1101/2024.12.10.627768 — microbiology — Posted on 2024-12-11
3308 Human plasma metabolic environment favours HIV replication in primary CD4 T lymphocytes
Chauveau, L.; Fortuin, A.; Lecante, A.; Lager-Lachaud, N.; Boulay, A.; Blanchet, F. P.; Bellvert, F.; Briant, L.; Battini, J.-L.
10.1101/2024.12.10.627699 — microbiology — Posted on 2024-12-11
3309 Calibration-free estimation of field dependent aberrations for single molecule localization microscopy across large fields of view
Rieger, B.; Stallinga, S.; Droste, I.; Lidke, K. A.; Khan, S.; van Werkhoven, B.; Heldens, S.; Schuitema, E.
10.1101/2024.12.11.627909 — microbiology — Posted on 2024-12-11
3310 Programming the elongation of mammalian cell aggregates with synthetic gene circuits
Courte, J.; Chung, C.; Jain, N.; Salazar, C.; Phuchane, N.; Grosser, S.; Lam, C.; Morsut, L.
10.1101/2024.12.11.627621 — synthetic biology — Posted on 2024-12-11
3311 Engineering a Biosynthetic Pathway for the Production of (+)-Brevianamides A and B in Escherichia coli
Sandoval Hurtado, C. P.; Kelly, S. P.; Shende, V. V.; Perez, M.; Curtis, B.; Newmister, S. A.; Ott, K.; Pereira, F.; Sherman, D. H.
10.1101/2024.12.10.627567 — synthetic biology — Posted on 2024-12-11
3314 Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins
May, A. J.; Lella, M.; Lindenberger, J.; Berkman, A.; Dutta, M.; Barr, M.; Parks, R.; Newman, A.; Huang, X.; Kumar, U.; Song, K.; Ilevbare, V.; Sammour, S.; Park, C. S.; Adhikari, R. D.; Devkota, P.; Janowska, K.; Liu, Y.; Scapellato, G.; Spence, T. N.; Mansouri, K.; Edwards, R. J.; Haynes, B. F.; Acharya, P.
10.1101/2024.12.11.627382 — biochemistry — Posted on 2024-12-11
3315 The Swiss Army Knife of Alginate Manipulation - A Gut Bacterium Alginate Lyase with Diverse Catalytic Activities
Tandrup, T.; Rivas-Fernandez, J. P.; Madsen, M.; Ronne, M. E.; Petersen, A. B.; Klau, L. J.; Tondervik, A.; Wilkens, C.; Aachmann, F. L.; Rovira, C.; Svensson, B.
10.1101/2024.12.11.627697 — biochemistry — Posted on 2024-12-11
3317 Gut Microbiome Signatures During Acute Infection Predict Long COVID
Comba, I. Y.; Mars, R. T.; Yang, L.; Dumais, M.; Chen, J. Y.; Van Gorp, T. M.; Harrington, J. J.; Sinnwell, J. P.; Johnson, S.; Holland, L. R.; Khan, A. K.; Lim, E.; Aakre, C.; Athreya, A.; Gerber, G. K.; O'Horo, J. C.; Lazaridis, K.; Kashyap, P. C.
10.1101/2024.12.10.626852 — genomics — Posted on 2024-12-11
3318 CRISPR-based environmental biosurveillance assisted via artificial intelligence design of guide-RNAs
Duran-Vinet, B.; Stanton, J.-A. L.; Jeunen, G.-J.; von Ammon, U.; Treece, J.; Pochon, X.; Zaiko, A.; Gemmell, N.
10.1101/2024.12.10.627849 — molecular biology — Posted on 2024-12-11
3321 Vibrio cholerae O1 El Tor A1552 encodes two functional ornithine lipid synthases and induces ornithine lipid formation under low phosphate and under low salinity growth conditions.
Vences-Guzman, M. A.; Olea-Ozuna, R. J.; Martinez-Mendez, R.; Escobedo-Hinojosa, W. I.; Castro-Santillan, M.; Guan, Z.; Zamorano-Sanchez, D.; Sohlenkamp, C.
10.1101/2024.12.11.627999 — microbiology — Posted on 2024-12-11
3323 Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI
Lopatto, E. D. B.; Santiago-Borges, J. M.; Sanick, D. A.; Malladi, S. K.; Azimzadeh, P. N.; Timm, M. W.; Fox, I. F.; Schmitz, A. J.; Turner, J. S.; Ahmed, S. S.; Ortinau, L.; Gualberto, N. C.; Pinkner, J. S.; Dodson, K. W.; Ellebedy, A. H.; Kau, A. L.; Hultgren, S. J.
10.1101/2024.12.10.627638 — microbiology — Posted on 2024-12-11
3325 Detection of exotic biosecurity threat ribgrass mosaic virus and novel tobamoviruses through metatranscriptomic sequencing of animal gut content
Mahar, J.; Mifsud, J. C.; Van Brussel, K.; Lachenauer, A. E.; Harvey, E.; Turnbull, O. M.; Bonat, S.; Newsome, T. M.; Olsson, A.; Chiu-Werner, A.; Jones, M. E.; Holmes, E. C.; Maina, S.
10.1101/2024.12.10.627875 — microbiology — Posted on 2024-12-11
3326 Two strains of Toscana virus show different virulence and replication capacity in mice and cell culture models
Roy, M.; Lacote, S.; Desloire, S.; Thiesson, A.; Pulido, C.; Aurine, N.; Mathieu, C.; Pain, B.; marianneau, P.; Arnaud, F.; Ratinier, M.
10.1101/2024.12.11.627885 — microbiology — Posted on 2024-12-11
3330 Chemoreceptor family in plant-associated bacteria responds preferentially to the plant signal molecule glycerol 3-phosphate
Velando, F.; Xing, J.; Genova, R.; Cerna-Vargas, J. P.; Vazquez, R.; Matilla, M. A.; Jouline, I.; Krell, T.
10.1101/2024.12.10.627748 — microbiology — Posted on 2024-12-11
3332 Direct Intercellular Vesicle Exchange between Adjacent Cells
Minakawa, T.; Katsuno, T.; Okamoto-Furuta, K.; Ando, R.; Ishidate, F.; Fujiwara, T. K.; Cho, D.; Takehana, S.; Sato, Y.; Tabata, Y.; Miyawaki, A.; Yamashita, J. K.
10.1101/2024.12.11.626728 — cell biology — Posted on 2024-12-11
3333 New insights into the cultivability of human milk microbiota from ingestion to digestion and implications for its immunomodulatory properties
Le Bras, C.; Mouchard, A.; Rault, L.; Cochet, M.-F.; Menard, O.; Jacquet, N.; Chuat, V.; Valence, F.; Le Loir, Y.; Bellanger, A.; Deglaire, A.; Le Huerou-Luron, I.; EVEN, S.
10.1101/2024.12.11.626747 — microbiology — Posted on 2024-12-11
3336 Renal arterial dysfunction, impaired pressure natriuresis and salt-sensitivity in a mouse model of Cushing syndrome
Costello, H. M.; Grenier, C.; Ivy, J. R.; Jones, N. K.; Stewart, K.; Holmes, M. C.; Livingstone, D. E.; Dhaun, N.; Bailey, M. A.
10.1101/2024.12.11.625204 — physiology — Posted on 2024-12-11
3337 Lipid specificity of action of SARS-CoV-2 fusion peptide fragments on model membranes
Shekunov, E. V.; Volynsky, P. E.; Efimova, S. S.; Aliper, E. T.; Efremov, R. G.; Ostroumova, O. S.
10.1101/2024.12.11.627892 — biophysics — Posted on 2024-12-11
3339 Alignment Free Viral Sequence Classification
van Zyl, D. J.; Dunaiski, M.; Tegally, H.; Baxter, C.; The INFORM Africa research study group, ; de Oliveira, T.; Xavier, J. S.
10.1101/2024.12.10.627186 — genomics — Posted on 2024-12-11
3340 Scaling ecological niches from individuals to populations and beyond
Lu, M.; Yanco, S.; Carlson, B.; Winner, K.; Cohen, J.; Ellis Soto, D.; Sharma, S.; Rogers, W.; Jetz, W.
10.1101/2024.12.06.627157 — ecology — Posted on 2024-12-11
3341 Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model
Huang, X.; Johnson, A. E.; Brehm, J. N.; Do, T. V. T.; Auchtung, T. A.; McCullough, H. C.; Lerma, A. I.; Haidacher, S. J.; Hoch, K. M.; Horvath, T. D.; Sorg, J. A.; Haag, A.; Auchtung, J. M.
10.1101/2024.07.17.603937 — microbiology — Posted on 2024-12-11
3342 Delivery of Peptide Coacervates to Form Stable Interaction Hubs In Cells
Tu, W.; Theisen, R.; Jin, P.; Chenoweth, D. M.; Patel, A. J.; Good, M. C.
10.1101/2024.11.26.625566 — synthetic biology — Posted on 2024-12-11
3343 An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
Thompson, J. R.; Nelson, E. D.; Tippani, M.; Ramnauth, A. D.; Divecha, H. R.; Miller, R. A.; Eagles, N. J.; Pattie, E. A.; Kwon, S. H.; Bach, S. V.; Kaipa, U. M.; Yao, J.; Hou, C.; Kleinman, J. E.; Collado-Torres, L.; Han, S.; Maynard, K. R.; Hyde, T. M.; Martinowich, K.; Page, S. C.; Hicks, S. C.
10.1101/2024.04.26.590643 — neuroscience — Posted on 2024-12-11
3348 Large MAF Transcription Factors Reawaken Evolutionarily Dormant Fast-Glycolytic Type IIb Myofibers in Human Skeletal Muscle
Sadaki, S.; Tsuji, R.; Hayashi, T.; Watanabe, M.; Iwai, R.; Wenchao, G.; Semenova, E. A.; Sultanov, R. I.; Zhelankin, A. V.; Generozov, E. V.; Ahmetov, I.; Sakakibara, I.; Ojima, K.; Sakurai, H.; Muratani, M.; Kudo, T.; Takahashi, S.; Fujita, R.
10.1101/2024.12.09.627660 — cell biology — Posted on 2024-12-11
3349 Microglia from patients with multiple sclerosis display a cell-autonomous immune activation state
Hyvarinen, T.; Lotila, J.; Giudice, L.; Tujula, I.; Nylund, M.; Ohtonen, S.; Scoyni, F.; Jantti, H.; Pihlava, S.; Skottman, H.; Narkilahti, S.; Airas, L.; Malm, T.; Hagman, S.
10.1101/2024.12.10.627477 — neuroscience — Posted on 2024-12-11
3350 ATF5-Dependent GDF15 Expression Mediates Anesthesia-Induced Neuroprotection Against Stroke
Ju, X.; Zhang, T.; Cui, J.; Lee, Y.; Lee, S.; Kim, H. M.; Hong, B.; Park, J.; Choi, C. H.; Yi, H.-S.; Heo, J. Y.; Chung, W.
10.1101/2024.12.06.627155 — neuroscience — Posted on 2024-12-11
3351 Chromosome-level reference genome assembly for the mountain hare (Lepus timidus)
Fekete, Z.; Absolon, D. E.; Michell, C.; Wood, J. M. D.; Goffart, S.; Pohjoismaki, J. L. O.
10.1101/2024.06.10.598177 — genomics — Posted on 2024-12-11
3352 Apocarotenoid signaling regulates meristem activity and shapes shoot and root lateral organ formation in Arabidopsis
Sierra, J.; Escobar-Tovar, L.; Napsucialy-Mendivil, S.; Oltehua-Lopez, O.; Dubrovsky, J. G.; McQuinn, R. P.; Leon, P.
10.1101/2024.12.09.627628 — plant biology — Posted on 2024-12-11
3356 What challenges remain in harmonizing cytomegalovirus viral load quantification across laboratories?
Boutolleau, D.; L'Honneur, A.-S.; Germi, R.; Chanzy, B.; Archimbaud, C.; Rzadkowolski, C.; Raimbourg, J.-B.; Gauthier, D.; Thibault, V.
10.1101/2024.12.09.627549 — microbiology — Posted on 2024-12-11
3359 Eukaryotic Translation Initiation Factor Loaded Extracellular Vesicles Promotes Macrophage Cholesterol Metabolism in ovarian cancer
Mittal, S.; Nenwani, M.; Kadamberi, I. P.; Kumar, S.; Animasahun, O.; George, J.; Tsaih, S. W.; Gupta, P.; Singh, M.; Geethadevi, A.; Dey, C.; Meurs, N.; Shankaran, A.; Chaluvally-Raghavan, P.; Nagrath, D.; Pradeep, S.
10.1101/2024.12.06.627180 — cancer biology — Posted on 2024-12-11
3360 STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunity
Girard, M.; Yu, T.; Batista, N. V.; Yeung, K. K.; Lamorte, S.; Gao, W.; Liu, M.; McGaha, T. L.; Watts, T. H.
10.1101/2024.12.08.627385 — immunology — Posted on 2024-12-11
3361 Synchronous activation of striatal cholinergic interneurons induces local serotonin release
Matityahu, L.; Hobel, Z. B.; Berkowitz, N.; Malgady, J. M.; Gilin, N.; Plotkin, J. L.; Goldberg, J. A.
10.1101/2024.11.03.621726 — neuroscience — Posted on 2024-12-11
3363 Wnt target IQGAP3 promotes Wnt signaling via disrupting Axin1-CK1α interaction.
Rahmat, M. B.; Hussain, A.; Teh, Y. X.; Dutta, B.; Pundrik, S.; Kappei, D.; Ito, Y.
10.1101/2024.12.10.626710 — cancer biology — Posted on 2024-12-11
3364 Inhibition of DKK-1 by WAY262611 Inhibits Osteosarcoma Metastasis
Tal, A.; Gunawardana-Zeigler, S.; Peng, D.; Tan, Y.; Perez, N. M.; Offenbacher, R.; Kastner, L.; Ciero, P.; Randolph, M. E.; Gong, Y.; Deng, H.-W.; Cahan, P.; Loeb, D. M.
10.1101/2024.12.10.627181 — cancer biology — Posted on 2024-12-11
3371 The CECR2 bromodomain displays distinct binding modes to select for acetylated histone proteins versus non-histone ligands.
Phillips, M.; Cook, E. D.; Marunde, M. R.; Tonelli, M.; Khan, L.; Henrickson, A.; Lignos, J. M.; Stein, J. L.; Stein, G. S.; Frietze, S.; Demeler, B.; Glass, K. C.
10.1101/2024.12.09.627393 — biochemistry — Posted on 2024-12-11
3372 H3.1K27M-induced misregulation of the TSK/TONSL-H3.1 pathway causes genomic instability
Yuan, W.; Huang, Y.-C.; LeBlanc, C.; Poulet, A.; Valsakumar, D.; van Wolfswinkel, J. C.; Voigt, P.; Jacob, Y.
10.1101/2024.12.09.627617 — genetics — Posted on 2024-12-11
3374 Pervasive divergence in protein thermostability is mediated by both structural changes and cellular environments
Walunjkar, N.; Lai, T. Y.; Akhter, N.; Miller, J. H.; Bettinger, J. Q.; Marcus, E.; Phizicky, E. M.; Ghaemmaghami, S.; Fay, J. C.
10.1101/2024.12.09.627561 — evolutionary biology — Posted on 2024-12-11
3375 The evolution of heteromorphic sex chromosomes in plants
Carey, S. B.; Bentz, P. C.; Lovell, J. T.; Akozbek, L. M.; Havill, J. S.; Padgitt-Cobb, L.; Lynch, R. C.; Allsing, N.; Osmanski, A.; Easterling, K. A.; Orozco, L. R.; Hale, H.; McCoy, H.; Meharg, Z.; McKay, J.; Grimwood, J. B.; Vergara, D.; Guerrero, R. F.; Kane, N.; Michael, T. P.; Muehlbauer, G.; Harkess, A.
10.1101/2024.12.09.627636 — evolutionary biology — Posted on 2024-12-11
3376 The MUC19 gene in Denisovans, Neanderthals, and Modern Humans: An Evolutionary History of Recurrent Introgression and Natural Selection
Villanea, F. A.; Peede, D.; Kaufman, E. J.; Anorve-Garibay, V.; Dillon, K. E. W.; Zeloni, R.; Marnetto, d.; Moorjani, P.; Jay, F.; Valdmanis, P. N.; Avila-Arcos, M. C.; Huerta-Sanchez, E.
10.1101/2023.09.25.559202 — evolutionary biology — Posted on 2024-12-11
3380 Downstream branches of receptor tyrosine kinase signaling act interdependently to shape the face
Hanne, N.; Hu, D.; Vidal-Garcia, M.; Allen, C.; Shakir, M. B.; Liu, W.; Hallgrimsson, B.; Marcucio, R.
10.1101/2024.12.10.627829 — developmental biology — Posted on 2024-12-11
3382 The Role of BAZ2-dependent Chromatin Remodeling in Suppressing G4 DNA Structures and Associated Genomic Instability
Vandeuren, A. L.; O'Dare, K.; Wilson, R. H. C.; van Eijk, P.; Julio, L. R.; Macleod, S. G.; Chee, E.; Salpukas, A.; Kriz, E. M.; Lantz, G. A.; Gordon, S. J. V.; Elsässer, S. J.; Reed, S. H.; Day, T. A.
10.1101/2024.12.10.627505 — molecular biology — Posted on 2024-12-11
3384 LongTrack: long read metagenomics-based precise tracking of bacterial strains and their genomic changes after fecal microbiota transplantation
Fan, Y.; Ni, M.; Aggarwala, V.; Mead, E. A.; Ksiezarek, M.; Cao, L.; Kamm, M. A.; Borody, T.; Paramsothy, S.; Kaakoush, N. O.; Grinspan, A.; Faith, J. J.; Fang, G.
10.1101/2024.09.30.615906 — microbiology — Posted on 2024-12-11
3385 Resource landscape shapes the composition and stability of the human vaginal microbiota
Kamiya, T.; Sofonea, M. T.; France, M.; Tessandier, N.; Bravo, I. G.; Murall, C. L.; Ravel, J.; Alizon, S.
10.1101/2024.11.12.622464 — microbiology — Posted on 2024-12-11
3386 Abundance measurements reveal the balance between lysis and lysogeny in the human gut microbiome
Lopez, J. A.; McKeithen-Mead, S.; Shi, H.; Nguyen, T. H.; Huang, K. C.; Good, B. H.
10.1101/2024.09.27.614587 — microbiology — Posted on 2024-12-11
3388 Clonally expanded IgG antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections
Agrafiotis, A.; Kuhn, R.; Panetti, C.; Venerito, M.; Phandee, H.; Stalder, L.; Shlesinger, D.; DArcy, V. M.; Hong, K.-L.; van Ginneken, D.; Genovese, A.; Joller, N.; Oxenius, A.; Reddy, S. T.; Yermanos, A.
10.1101/2024.12.09.627526 — immunology — Posted on 2024-12-11
3389 Reduced and Redundant: Information Processing of Prediction Errors during Sleep
Blume, C.; Dauphin, M.; Niedernhuber, M.; Spitschan, M.; Meyer, M. P.; Cajochen, C.; Bekinschtein, T.; Canales-Johnson, A.
10.1101/2024.12.06.627143 — neuroscience — Posted on 2024-12-11
3390 Embodiment of an artificial limb in the mouse model
Hayatou, Z.; Wang, H.; Chaillet, A.; Shulz, D.; Ego-Stengel, V.; Estebanez, L.
10.1101/2024.04.25.591084 — neuroscience — Posted on 2024-12-11
3393 Binocular integration of prey stimuli in the zebrafish visual system
Tian, G.; Lam, T. K. C.; Yan, G.; He, Y.; Khan, B.; Qu, J.; Semmelhack, J. L.
10.1101/2024.09.08.611846 — neuroscience — Posted on 2024-12-11
3396 Photosynthetic and Genetic Adaptations Underpinning the Resilience of Cistanthe longiscapa in the Atacama Desert
Sandoval-Ibanez, O.; Tapia-Reyes, P.; Riveros, A.; Yusta, R.; Chang, S.; Ossa, P.; Nilo-Poyanco, R.; Moreno, A. A.; Miquel, A.; Almeida, A. M.; Zurita-Silva, A.; Orellana, D.; Baeza, C.; Blanco-Herrera, F.; Di Genova, A.; Allende, M. L.; Gonzalez, M.; Maass, A. E.; Montecino, M.; Gutierrez, R. A.; Bock, R.; Meneses, C.; Orellana, A.
10.1101/2024.12.08.627406 — plant biology — Posted on 2024-12-11
3397 Single-cell mass spectrometry reveals heterogeneous triterpenic acid accumulation in apple callus-derived cells
Laezza, C.; Heinicke, S.; Wurlitzer, J.; D'Amelia, V.; Caputi, L.; Rigano, M. M.; O'Connor, S. E.
10.1101/2024.12.08.627150 — plant biology — Posted on 2024-12-11
3402 Protein language model pseudolikelihoods capture features of in vivo B cell selection and evolution
van Ginneken, D.; Samant, A.; Daga-Krumins, K.; Agrafiotis, A.; Kladis, E.; Reddy, S. T.; Yermanos, A.
10.1101/2024.12.09.627494 — bioinformatics — Posted on 2024-12-11
3404 Toward mastering the cell language by learning to generate
Chen, Y.; Bian, H.; Wei, L.; Jia, J.; Dong, X.; Li, Y.; Zhao, Y.; Wu, X.; Li, C.; Luo, E.; Xiao, C.; Hao, M.; Zhang, X.
10.1101/2024.01.25.577152 — bioinformatics — Posted on 2024-12-11
3405 Inkube: An all-in-one solution for neuron culturing, electrophysiology, and fluidic exchange
Maurer, B.; Fassbind, S.; Ruff, T.; Duru, J.; Spacone, G.; Rodde, T.; Voros, J.; Ihle, S. J.
10.1101/2024.12.06.627248 — bioengineering — Posted on 2024-12-11
3406 Octopus can use odor plumes to find food
Weertman, W. L.; Gopal, V.; Sivitilli, D. M.; Scheel, D.; Gire, D. H.
10.1101/2024.08.02.606436 — animal behavior and cognition — Posted on 2024-12-11
3407 Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina
Bidard, F.; Grognet, P.; Lelandais, G.; Imbeaud, S.; Mucchielli-Giorgi, M. H.; Debuchy, R.; Berteaux-Lecellier, V.; Malagnac, F.
10.1101/2024.12.09.627484 — genomics — Posted on 2024-12-11
3410 Patterns and drivers of diatom diversity and abundance in the global ocean
Pierella Karlusich, J. J.; Cosnier, K.; Zinger, L.; Henry, N.; Nef, C.; Bernard, G.; Scalco, E.; Dvorak, E.; Tara Oceans Coordinators, ; Jimenez Vieira, F. R.; Delage, E.; Chaffron, S.; Ovchinnikov, S.; Zingone, A.; Bowler, C.
10.1101/2024.06.08.598090 — ecology — Posted on 2024-12-11
3411 Resolving the design principles that control postnatal vascular growth and scaling
Pichardo, D.; Braun, J.; Dutta, S.; Patra, D.; Bougaran, P.; Mompeon, A.; Ma, F.; Stock, S. R.; Choi, S.; Garcia-Ortega, L.; Pratama, M. Y.; Pichardo, D.; Ramkhelawon, B.; Benedito, R.; Bautch, V. L.; Ornitz, D. M.; Goyal, Y.; Iruela-Arispe, M. L.
10.1101/2024.12.10.627758 — developmental biology — Posted on 2024-12-11
3413 Functional redundancy and formin-independent localization of tropomyosin isoforms in Saccharomyces cerevisiae
Dhar, A.; VT, B.; Biswas, S.; Kumari, J.; Sridhara, A.; Brahmendra, J. S.; Shekhar, S.; Palani, S.
10.1101/2024.04.04.587703 — cell biology — Posted on 2024-12-11
3414 Host-encoded DNA methyltransferases modify the epigenome and host tropism of invading phages
Takahashi, M.; Hiraoka, S.; Matsumoto, Y.; Shibagaki, R.; Ujihara, T.; Maeda, H.; Seo, S.; Nagasaki, K.; Takeuchi, H.; Matsuzaki, S.
10.1101/2024.05.05.592563 — microbiology — Posted on 2024-12-11
3417 Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study
Hendrikse, J. J.; Brooks, E.; Wallis, S.; Curtin, D.; Rogasch, N. C.; Yucel, M.; Biabani, M.; Stagg, C. J.; Bellgrove, M.; McIntyre, R.; Suo, C.; Coxon, J.
10.1101/2024.12.07.627311 — neuroscience — Posted on 2024-12-11
3418 Optochemical profiling of NMDA receptor molecular diversity at synaptic and extrasynaptic sites
Sicard, A.; Tian, M.; Mostefai, Z.; Shi, S.; Cardoso, C.; Zamith, J.; McCort-Tranchepain, I.; Charrier, C.; Paoletti, P.; Mony, L.
10.1101/2024.10.14.618157 — neuroscience — Posted on 2024-12-11
3425 Adapting C4 photosynthesis to atmospheric change and increasing productivity by elevating Rubisco content in Sorghum and Sugarcane
Salesse-Smith, C. E.; Adar, N.; Kannan, B.; Nguyen, T.; Wei, W.; Guo, M.; Ge, Z.; Altpeter, F.; Clemente, T. E.; Long, S. P.
10.1101/2024.05.02.592081 — plant biology — Posted on 2024-12-11
3428 A family of bacterial actin homologues forms a 3-stranded tubular structure
Bergeron, J.; Lale-Farjat, S. L.; Lewicka, H. M.; Parry, C.; Kollman, J. M.
10.1101/2023.11.07.565980 — biophysics — Posted on 2024-12-11
3433 StarPhase: Comprehensive Phase-Aware Pharmacogenomic Diplotyper for Long-Read Sequencing Data
Holt, J. M.; Harting, J.; Chen, X.; Baker, D.; Saunders, C. T.; Kronenberg, Z.; Gonzaludo, N.; Yoo, B.; Hudjashov, G.; Joeloo, M.; Lawlor, J. M. J.; Lim, W. K.; Estonian Biobank Research Team, ; Jamuar, S. S.; Cooper, G. M.; Milani, L.; Pastinen, T.; Eberle, M. A.
10.1101/2024.12.10.627527 — bioinformatics — Posted on 2024-12-11
3434 The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine
Burtnyak, L.; Yuan, Y.; Pan, X.; Gunaratne, L.; Silveira d'Almeida, G.; Martinelli, M.; Reed, C. J.; Fernandez, J.; Patel, B. I.; Marquez, I.; Ehrenhofer-Murray, A.; Swairjo, M. A.; Alfonzo, J. J.; Green, B. D.; Kelly, V. P.; de Crecy-Lagard, V.
10.1101/2024.12.03.625470 — biochemistry — Posted on 2024-12-11
3435 Tracing the stepwise Darwinian evolution of a plant halogenase
Kim, C. Y.; Kastner, D. W.; Mitchell, A. J.; Gutierrez, M. A.; Yao, J. S.; Neumann, E. N.; Kulik, H. J.; Weng, J.-K.
10.1101/2024.12.09.627616 — biochemistry — Posted on 2024-12-11
3436 Marigold: A machine learning-based web app for zebrafish pose tracking
Teicher, G.; Riffe, R. M.; Barnaby, W.; Martin, G.; Clayton, B. E.; Trapani, J. G.; Downes, G. B.
10.1101/2024.05.31.596910 — animal behavior and cognition — Posted on 2024-12-11
3438 Trophic level associated gut length divergence evolved under sexual conflict in Lake Malawi cichlids
Carmona Baez, A.; Ciccotto, P. J.; Moore, E. C.; Peterson, E. N.; Lamm, M. S.; Roberts, N. B.; Coyle, K. P.; Barker, M. K.; Dickson, E.; Cass, A. N.; da Silva Pereira, G. S.; Zeng, Z.-B.; Guerrero, R. F.; Roberts, R. B.
10.1101/2024.12.09.627601 — genetics — Posted on 2024-12-11
3441 Circatidal control of gene expression in the deep-sea hot vent shrimp Rimicaris leurokolos
Zhang, H.; Yahagi, T.; Miyamoto, N.; Chen, C.; Jiang, Q.; Qian, P.-Y.; Sun, J.
10.1101/2024.01.12.575359 — ecology — Posted on 2024-12-11
3443 THE FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycle
Hammond, T.; Choi, J. B.; Membreno, M. W.; Demeter, J.; Ng, R.; Bhattacharya, D.; Nguyen, T.; Bossard, C.; Hartmann, G. G.; Skotheim, J.; Jackson, P. K.; Pasca, A. M.; Rubin, S.; Sage, J.
10.1101/2024.12.10.627280 — cell biology — Posted on 2024-12-11
3445 Synergistic effects of tRNA modification defects in Escherichia coli K12.
Bacusmo, J. M.; Babor, J.; Hu, J.; Cao, B.; Kellner, S.; Szkrybalo, S.; Yuan, Y.; Sander, S.; Kuipers, P.; Mott, M.; Mori, H.; Dedon, P.; de Crecy-Lagard, V.
10.1101/2024.11.12.622971 — microbiology — Posted on 2024-12-11
3446 Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia
Diaz-Perez, S.; DeLong, J. H.; Rivier, C. A.; Lee, C.-Y.; Askenase, M. H.; Zhu, B.; Zhang, L.; Brennand, K. J.; Martins, A. J.; Sansing, L. H.
10.1101/2024.12.06.627202 — neuroscience — Posted on 2024-12-11
3447 The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus
Nikhil, K. L.; Singhal, B.; Granados-Fuentes, D.; Li, J.-S.; Kiss, I. Z.; Herzog, E. D.
10.1101/2024.12.06.627294 — neuroscience — Posted on 2024-12-11
3456 Parallelization of particle-based reaction-diffusion simulations using MPI
Guo, S.; Korolija, N.; Milfeld, K.; Jhaveri, A.; Sang, M.; Ying, Y. M.; Johnson, M. E.
10.1101/2024.12.06.627287 — biophysics — Posted on 2024-12-10
3457 DemoTape: Computational demultiplexing of targeted single-cell sequencing data
Borgsmueller, N.; Kuipers, J.; Gawron, J.; Roncador, M.; Pohly, M. F.; Acar, E.; Do, T. H. L.; Reisenauer, S. U.; Feldkamp, M. J.; Beisel, C.; Zenz, T.; Moor, A.; Beerenwinkel, N.
10.1101/2024.12.06.627152 — bioinformatics — Posted on 2024-12-10
3467 Scalable DNA Feature Generation and Transcription Factor Binding Prediction via Deep Surrogate Models
Kabir, A.; Inan, T. T.; Rasmussen, K.; Shehu, A.; Usheva, A.; Bishop, A.; Alexandrov, B. S.; Bhattarai, M.
10.1101/2024.12.06.626709 — genomics — Posted on 2024-12-10
3468 EXTRA-seq: a genome-integrated extended massively parallel reporter assay to quantify enhancer-promoter communication
Kribelbauer-Swietek, J. F.; Gardeux, V.; Llimos-Aubach, G.; Faltejskova, K.; Russeil, J.; Grenningloh, N.; Levassor, L.; Steiner, C.; Vondrasek, J.; Deplancke, B.
10.1101/2024.12.08.627402 — genomics — Posted on 2024-12-11
3470 Tropical Forest Soil Microbiome Modulates Leaf Heat Tolerance More Strongly Under Warming than Ambient Conditions
Hernandes Villani, G.; Grullon-Penkova, I. F.; Bartz, P.; Masanga, J.; Lasky, J. R.; Reed, S. C.; Cavaleri, M. A.; Wood, T. E.; Bachelot, B.
10.1101/2024.12.09.626610 — ecology — Posted on 2024-12-10
3472 N1-methylpseudouridine mRNA modification enhances efficiency and specificity of gene overexpression by preventing Prkra-mediated global translation repression
Lu, T.; Chen, A.; Wang, S.; Zhang, Y.; Yang, B.; Wang, J.; Fang, H.; Gong, Q.; Lu, A.; Liu, X.; Ma, P.; Mao, B.; Shi, D.-L.; Shao, M.
10.1101/2024.12.06.627293 — developmental biology — Posted on 2024-12-11
3473 The antigenic landscape of N1 neuraminidase in human influenza A virus strains isolated between 2009 and 2020
Portela Catani, J. P.; Smet, A.; Ysenbaert, T.; Amelinck, L.; Chan, Y.; Tadmor, D.; Davidson, P.; Ray, S.; Camire, E.; Han, L.; Zhang, J.; Cortes, G.; Roebke, K.; Baum, B.; Hamberger, J.; Giel-Moloney, M.; Saelens, X.; Vogel, T. U.
10.1101/2024.12.10.627724 — immunology — Posted on 2024-12-10
3474 Donor HLA DQ reactive B cells clonally expand under chronic immunosuppression and include atypical CD21lowCD27- B cells with high avidity germline B cell receptors.
Russum, S.; Sayin, I.; Shwetar, J.; Baughan, E.; Jeong, J. C.; Kim, A.; Reyentovich, A.; Moazami, N.; Zeevi, A.; Chong, A. S.; Habal, M.
10.1101/2024.12.06.627284 — immunology — Posted on 2024-12-10
3476 Collablots: Quantification of collagen VI levels and its structural disorganisation in cell cultures from patients with collagen VI-related dystrophies
Osegui-Barcenilla, N.; Sendino, M.; Martin-Gonzalez, S.; Gonzalez-Moro, I.; Benito-Agustino, A.; Torres-Conde, N.; Lopez-Martinez, A.; Jimenez-Mallebrera, C.; Lopez-Marquez, A.; Arechavala-Gomeza, V.
10.1101/2024.12.06.627141 — neuroscience — Posted on 2024-12-10
3478 Anti-obesity compounds, Semaglutide and LiPR, do not change the proportion of human and mouse POMC+ neurons
Jörgensen, S. K. M.; Surridge-Smith, M.; Jones, K.; Maletinska, L.; Allen, N. D.; Petrik, D.
10.1101/2024.12.06.627140 — neuroscience — Posted on 2024-12-11
3481 Element partitioning, element localisation and transcriptome responses of date palms exposed to NaCl
Pongrac, P.; Fischer, S.; Wright, G.; Thompson, J. A.; Kelemen, M.; Neugebauer, K.; Brown, L. K.; Vogel-Mikus, K.; Sala, M.; El-Serehy, H. A.; White, P. J.
10.1101/2024.12.07.627310 — plant biology — Posted on 2024-12-10
3482 Transgenic augmentation of erythroferrone in mice ameliorates anemia in adenine-induced chronic kidney disease
Czaya, B.; Olivera, J. D.; Zhang, M.; Lundin, A.; Castro, C. D.; Jung, G.; Nemeth, E.; Ganz, T.
10.1101/2024.12.06.627111 — pathology — Posted on 2024-12-10
3484 SOX2-induced IL-1alpha-mediated immune suppression drives epithelial dysplasia malignant transformation
Taner, H. F.; Gong, W.; Fitzsimonds, Z. R.; Li, Z.; Wu, Y.; He, Y.; Okuyama, K.; Cheng, W.; Kuczura, J.; Rajesh, S.; Manousidaki, A.; Feng, S.; Lee, M.; Nor, F.; Lanzel, E.; Demehri, S.; Polverini, P.; Nor, J.; Wang, T.; Que, J.; Wen, H.; Xie, Y.; Moon, J.; Lei, Y. L.
10.1101/2024.12.06.626475 — cancer biology — Posted on 2024-12-10
3485 Reversible and reusable compartmentalized microfluidic chip for coculture of dorsal root ganglion neurons
Moreau, S.; Berdines, R. F.; El Jalkh, T.; Simon, A.; Taret, G.; Fomina, A.; Becker, C.; Estevez-Torres, A.; Bernard, S.; Salmon, H.
10.1101/2024.12.10.627139 — biophysics — Posted on 2024-12-10
3486 A novel HLA Class II presentation prediction algorithm deciphers immunogenic CD4 epitopes specific to KRAS G12C
Sprague, D.; Hart, M. G.; Klein, J.; Kounlavouth, S.; Vegesna, R.; Rotunno, M.; Kraemer-Tardif, L. D.; Zhou, R.; Kemp, L.; Greeene, A. C.; Araya, J.; Mantilla, A.; Adeoye, B.; Dominguez, C.; Ferguson, A. R.; Johnson, M. L.; Davis, M. J.; Lane, M.; Palmer, C. D.; Jooss, K.; Dhanik, A.
10.1101/2024.12.06.627073 — bioinformatics — Posted on 2024-12-10
3490 Structural and Functional Insights into the Evolution of SARS-CoV-2 KP.3.1.1 Spike Protein
Feng, Z.; Huang, J.; Baboo, S.; Diedrich, J. K.; Bangaru, S.; Paulson, J. C.; Yates, J. R.; Yuan, M.; Wilson, I. A.; Ward, A. B.
10.1101/2024.12.10.627775 — immunology — Posted on 2024-12-10
3492 Investing in Open Science: Key Considerations for Funders
Cobb-Lewis, D. E.; Snyder, D.; Dumanis, S.; Thibault, R.; Marebwa, B.; Clark, E.; St.Clair, L.; Kirsch, L.; Durborow, M.; Riley, E. A. U.
10.1101/2024.12.09.627554 — scientific communication and education — Posted on 2024-12-10
3494 Differential control of mycobacteria among COVID-19 patients is associated with CD28+ CD8+ T cells
Llibre, A.; Siddiqui, H.; Pillaye, J.; Burel, J.; Jones, C.; Hill, H.; Faustini, S. E.; Windle, E.; Karim, H.; Sherry, E.; Green, C. A.; Dedicoat, M.; Stamataki, Z.; Cunningham, A. F.; O'Shea, M. K.
10.1101/2024.12.09.626962 — immunology — Posted on 2024-12-10
3495 Longitudinal cellular and humoral immune responses following Covid-19 BNT162b2-mRNA-based booster vaccination of craft and manual workers in Qatar.
Thomas, R.; Zaqout, A.; Meqbel, B.; Jafar, U.; Vaikath, N.; Aldushain, A.; Naik, A.; Shaath, H.; Al-Akl, N. S.; Adam, A.; Ali Moussa, H. Y.; Shin, K. C.; Taha, R. Z.; Abukhattab, M.; Almaslamani, M. A.; Alajez, N. M.; Arredouani, A.; Park, Y.; Abdulla, S. A.; El-Agnaf, O. M.; Omrani, A. S.; Decock, J.
10.1101/2024.12.10.627725 — immunology — Posted on 2024-12-10
3496 Accelerated amyloid deposition in SARS-CoV-2 infected mouse models of Alzheimer's disease
Parekh, P. A.; Badachhape, A. A.; Redd, J. R.; Bonilla, L. J.; Bhandari, P.; Kneubehl, A. R.; Bhavane, R.; Clinton, J. L. S.; Admane, P.; Menon, R.; Srivastava, M.; Sun, X.; Narang, S.; Tanifum, E.; Ghaghada, K. B.; Ronca, S. E.; Annapragada, A. V.
10.1101/2024.12.09.627570 — neuroscience — Posted on 2024-12-10
3497 The SARS-CoV-2 envelope PDZ Binding Motif acts as a virulence factor disrupting host's epithelial cell-cell junctions
Alvarez, F.; Melo, G. D. d.; Larrous, F.; Kergoat, L.; Boeda, B.; Michel, V.; Seilhean, D.; Tichit, M.; Hing, D.; Hardy, D.; Kornobis, E.; Bourhy, H.; Wolff, N.; Caillet-Saguy, C.
10.1101/2024.12.10.627528 — pathology — Posted on 2024-12-10
3498 SARITA: A Large Language Model for Generating the S1 Subunit of the SARS-CoV-2 Spike Protein
Rancati, S.; Nicora, G.; Bergomi, L.; Buonocore, T. M.; Czyz, D. M.; Parimbelli, E.; Bellazzi, R.; Salemi, M.; Prosperi, M.; Marini, S.
10.1101/2024.12.10.627777 — bioinformatics — Posted on 2024-12-10
3500 Orthrus: Towards Evolutionary and Functional RNA Foundation Models
Fradkin, P.; Shi, R.; Isaev, K.; Frey, B. J.; Morris, Q.; Lee, L. J.; Wang, B.
10.1101/2024.10.10.617658 — genomics — Posted on 2024-12-10
3501 THE IMPACT OF EXPERIMENTAL DESIGNS & SYSTEM SLOPPINESS ON THE PERSONALISATION PROCESS: A CARDIOVASCULAR PERSPECTIVE
Saxton, H.; Taylor, D. J.; Faulkner, G.; Halliday, I.; Newman, T.; Schenkel, T.; Morris, P. D.; Clayton, R. H.; Xu, X.
10.1101/2024.12.05.627122 — systems biology — Posted on 2024-12-10
3502 Nanoparticle Accumulation and Penetration in 3D Tumor Models: the Effect of Size, Shape, and Surface Charge
Cybulski, P.; Bravo, M.; Chen, J. J.-K.; Van Zundert, I.; Krzyzowska, S.; Taemaitree, F.; Uji-i, H.; Hofkens, J.; Rocha, S.; Fortuni, B.
10.1101/2024.12.06.626955 — cancer biology — Posted on 2024-12-10
3503 NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors
Hill, C.; Indeglia, A.; Picone, F.; Murphy, M.; Cipriano, C.; Maki, R. G.; Gardini, A.
10.1101/2024.04.15.589533 — cancer biology — Posted on 2024-12-10
3504 A FRET assay to quantitate levels of the human β-cardiac myosin interacting heads motif based on its near-atomic resolution structure
Goluguri, R. R.; Guhathakurta, P.; Nandwani, N.; Dawood, A.; Yokota, S.; Roopnarine, O.; Thomas, D. D.; Spudich, J.; Ruppel, K. M.
10.1101/2024.12.05.626936 — biophysics — Posted on 2024-12-10
3505 Improving design and normalization of multiplex proteomics study
Fang, H.; Shih, M.-C.; Jiang, L.; da Veiga Leprevost, F.; Jian, R.; Chan, J.; Nesvizhskii, A.; Snyder, M.; Tang, H.
10.1101/2024.12.05.627093 — bioinformatics — Posted on 2024-12-10
3508 A new universal chimeric-antigen receptor (CAR)- fragment antibody binder (FAB) split system for cancer immunotherapy
Arina, A.; Arauz, E.; Warzecha, K.; Masoumi, E.; Saaf, A.; Widlo, L.; Slezak, T.; Zieminska, A.; Dudek, K.; Schaefer, Z. P.; Lecka, M.; Usatyuk, S.; Weichselbaum, R. R.; Kossiakoff, A. A.
10.1101/2024.12.05.627079 — bioengineering — Posted on 2024-12-10
3509 Diploid origins, adaptation to polyploidy, and the beginning of rediploidization in allotetraploid Arabidopsis suecica
Burns, R.; Kulkarni, A.; Glushkevich, A.; Kolesnikova, U. K.; Kolar, F.; Scott, A. D.; Novikova, P. Y.
10.1101/2024.12.06.627142 — genomics — Posted on 2024-12-10
3510 Low mutation rate but high male-bias in the germline of a short-lived opossum
Pena-Garcia, Y.; Wang, R.; Raveendran, M.; Harris, R. A.; Samollow, P. B.; Rogers, J.; Hahn, M. W.
10.1101/2024.12.05.627076 — evolutionary biology — Posted on 2024-12-10
3513 An imbalance of naive and effector T-cell phenotypes in early type 1 diabetes across conventional and regulatory subsets
Niederlova, V.; Neuwirth, A.; Neuman, V.; Michalik, J.; Charvatova, B.; Modrak, M.; Sumnik, Z.; Stepanek, O.
10.1101/2024.12.05.627068 — immunology — Posted on 2024-12-10
3515 Insights into Dentatorubral-Pallidoluysian Atrophy from a new Drosophila model of disease
Prifti, M. V.; Nuga, O.; Dulay, R. O.; Patel, N. C.; Kula, T.; Libohova, K.; Jackson-Butler, A.; Tsou, W.-L.; Richardson, K.; Todi, S. V.
10.1101/2024.12.05.627083 — neuroscience — Posted on 2024-12-10
3519 Bridging the Dimensional Gap from Planar Spatial Transcriptomics to 3D Cell Atlases
Lin, S.; Wang, Z.; CUI, Y.; Zou, Q.; Han, C.; Yan, R.; Yang, Z.; Zhang, W.; Gao, R.; Song, J.; Zhang, M. Q.; Peng, H.; Yu, J.; Feng, J.; Zhao, Y.; Yuan, Z.
10.1101/2024.12.06.627127 — bioinformatics — Posted on 2024-12-10
3522 Motor sequence learning elicits mu peak-specific corticospinal plasticity
Suresh, T.; Iwane, F.; Zhang, M.; McElmurry, M.; Manesiya, M.; Freedberg, M. V.; Hussain, S.
10.1101/2024.07.31.606022 — neuroscience — Posted on 2024-12-10
3523 Nonuple atg8 mutant provides genetic evidence for functional specialization of ATG8 isoforms in Arabidopsis thaliana
Del Chiaro, A.; Grujic, N.; Zhao, J.; Papareddy, R. K.; Gao, P.; Ma, J.; Loefke, C.; Bhattacharya, A.; Gruetzner, R.; Bourguet, P.; Berger, F.; Kang, B.-H.; Marillonnet, S.; Dagdas, Y.
10.1101/2024.12.10.627464 — plant biology — Posted on 2024-12-10
3527 The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA double strand repair through mutual regulation of their protein levels
Mennerich, D.; Ashok, Y.; Vela-Rodriguez, C.; Hentilä, H. I.; Rall-Scharpf, M.; Wiesmüller, L.; Prunskaite-Hyyryläinen, R.; Lehtiö, L.; Kietzmann, T.
10.1101/2023.01.30.526213 — biochemistry — Posted on 2024-12-10
3528 Subfamily evolution analysis using nuclear and chloroplast data from the same reads
Witharana, E. P.; Iwasaki, T.; San, M. H.; Jayawardana, N. U.; Kotoda, N.; Yamamoto, M.; Nagano, Y.
10.1101/2024.01.15.575800 — genomics — Posted on 2024-12-10
3531 The tendon differentiation program is activated in human adipose stromal cells embedded in a 3D-collagen matrix
Horde, M.; Fouchard, J.; Laffray, X.; Blavet, C.; Bereziat, V.; Lagathu, C.; Gaut, L.; DUPREZ, D.; Havis, E.
10.1101/2024.04.25.591060 — developmental biology — Posted on 2024-12-10
3532 The Balbiani body is formed by microtubule-controlled molecular condensation of Buc in early oogenesis
Kar, S.; Deis, R.; Ahmad, A.; Bogoch, Y.; Dominitz, A.; Shvaizer, G.; Sasson, E.; Mytlis, A.; Ben-Zvi, A.; Elkouby, Y. M.
10.1101/2022.03.11.484019 — developmental biology — Posted on 2024-12-10
3533 Repeated cigarette smoke exposure attenuates the proliferation rate of primary human lung fibroblasts in vitro
Cannard, E. C.; Kronseder, A.; Karrasch, S.; Kahnert, K.; Nowak, D.; Lehmann, M.; Holz, O.; Stoleriu, M. G.; Jorres, R. A.
10.1101/2024.11.27.625673 — cell biology — Posted on 2024-12-10
3534 Immortalized Intestinal Telocytes - A Stem Cell Niche In Vitro
Canella, M.; Gharbi, A.; Duran, D.; Corem, N.; Ben-Neriah, Y.; Birimberg-Schwartz, L.; Ben-Porath, I.; Grunewald, M.; Shoshkes Carmel, M.
10.1101/2024.11.27.625598 — cell biology — Posted on 2024-12-10
3537 Pandemic Vibrio parahaemolyticus wave succession by gene loss
Yang, C.; Qiu, H.; Svensson, S. L.; Ni, C.; Gao, S.; Jia, Z.; Wen, H.; Xie, L.; Xu, W.; Qin, Y.; Lin, S.; Wang, J.; Zhang, Y.; Li, Y.; Jiang, M.; Shi, X.; Hu, Q.; Zhou, Z.; Chao, Y.; Yang, R.; Cui, Y.; Martinez-Urtaza, J.; Wang, H.; Falush, D.
10.1101/2024.06.03.596356 — microbiology — Posted on 2024-12-10
3540 Multilayer Network Analysis across Cortical Depths in Resting-State 7T fMRI
Kotlarz, P.; Lankinen, K.; Hakonen, M.; Turpin, T.; Polimeni, J. R.; Ahveninen, J.
10.1101/2023.12.23.573208 — neuroscience — Posted on 2024-12-10
3541 Brain wave dynamics in Hopfield Kuramoto model
Yao, R.; Li, Y.; Yao, X.; Wang, K.; Qu, J.; Zou, X.; HONG, B.
10.1101/2024.08.13.607707 — neuroscience — Posted on 2024-12-10
3543 The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke
Li, T.; Yang, L.; Tu, J.; Hao, Y.; Zhu, Z.; Xiong, Y.; Gao, Q.; Zhou, L.; Xie, G.; Zhang, D.; Li, X.; Jin, Y.; Zhang, Y.; Zhao, B.; Li, N.; Wang, X.; Jia, J.-M.
10.1101/2023.12.07.570712 — neuroscience — Posted on 2024-12-10
3545 Reevaluating the Neural Noise Hypothesis in Dyslexia: Insights from EEG and 7T MRS Biomarkers
Glica, A.; Wasilewska, K.; Jurkowska, J.; Zygierewicz, J.; Kossowski, B.; Jednorog, K.
10.1101/2024.06.11.598476 — neuroscience — Posted on 2024-12-10
3547 Human TUBA1B short open reading frame product regulates cancer cell growth via importin-β
Tao, Y.; Bai, X.; Zhou, Y.; Zhao, Y.; Yang, L.; Zhang, S.; Liu, H.; Huang, X.; Schneider, E.; Zampetaki, A.; Margariti, A.; Giacca, M.; Arnold, J. N.; Zeng, L.; Cai, T.
10.1101/2023.08.26.554759 — cancer biology — Posted on 2024-12-10
3549 A bHLH interaction code controls bipotential differentiation and self-renewal in the Drosophila gut
Puig-Barbe, A.; Dettmann, S.; Nirello, V. D.; Moor, H. E.; Azami, S.; Edgar, B. A.; Varga-Weisz, P.; Korzelius, J.; de Navascues, J.
10.1101/685347 — developmental biology — Posted on 2024-12-10
3551 Ablation of sympathetic nerve-β3 adrenergic receptor-mediated adipose tissue lipolysis attenuates alcohol-induced liver injury in mice
Wickramasinghe, P.; Caron, A.; Eadha, S.; Parupalli, P.; Ganapavarapu, S.; Elmquist, J. K.; Liu, C.; Jia, L.
10.1101/2024.12.08.627372 — physiology — Posted on 2024-12-10
3552 Dysregulation of cellular iron predisposes chemotherapy resistant cancer cells to ferroptosis
Loftus, L.; Rolle, L. T. A.; Cherry, C.; Patatanian, M.; Orzolek, L.; Wang, B.; Pienta, K.; Amend, S. R.
10.1101/2024.12.05.626685 — cancer biology — Posted on 2024-12-10
3554 UltimateSynth: MRI Physics for Pan-Contrast AI
Adams, R.; Zhao, W.; Hu, S.; Lyu, W.; Huynh, K. M.; Ahmad, S.; Ma, D.; Yap, P.-T.
10.1101/2024.12.05.627056 — bioinformatics — Posted on 2024-12-10
3556 A subset of human choroid plexus epithelial cells exhibit mitochondrial eccentricity and distinct expression of the pigmentation-associated enzyme TYRP1
Groh, A. M.; Premachandran, S.; Creeggan, F.; Yaqubi, M.; Zandee, S.; Prat, A.; Antel, J. P.; Moore, G. W.; Stratton, J. A.
10.1101/2024.12.05.627055 — neuroscience — Posted on 2024-12-10
3557 Gabapentin's Effect on Human Dorsal Root Ganglia: Donor-Specific Electrophysiological and Transcriptomic Profiles
Demeter, J. B.; Zurek, N. A.; Koch, M. R.; Goins, A. E.; Holguin, C. O.; Shilling, M. W.; Ehsanian, R.; Alles, S. R.; de la Pena, J. B.
10.1101/2024.12.05.627067 — neuroscience — Posted on 2024-12-10
3558 Aging and the Spectral Properties of Brain Hemodynamics
Park, K. Y.; Snyder, A. Z.; Goyal, M. S.; Laumann, T. O.; Lee, J. J.; Adeyemo, B.; Metcalf, N.; Vlassenko, A. G.; Shimony, J. S.; Leuthardt, E. C.
10.1101/2024.12.05.626723 — neuroscience — Posted on 2024-12-10
3560 A skewed picture of functional diversity in global drylands
Tordoni, E.; Puglielli, G.; Beccari, E.; Carmona, C. P.
10.1101/2024.12.09.627500 — ecology — Posted on 2024-12-10
3564 Building Inclusive Leadership: A Biosciences Approach
Armstrong, E. M.; Bach, L.; Woodling, N.; Robinson, P.; Walden, H.; Jones, M.
10.1101/2024.12.09.626597 — scientific communication and education — Posted on 2024-12-10
3565 Genetic basis of immunity in Indian cattle as revealed by comparative analysis of Bos genome
Thambiraja, M.; Iyengar, S. K.; Sathishkumar, B.; Kavuru, S. R.; Katari, A.; Singh, D.; Onteru, S. K.; Yennamalli, R. M.
10.1101/2024.12.09.627532 — bioinformatics — Posted on 2024-12-10
3568 A new class of natural anthelmintics targeting lipid metabolism
Zahreddine, H.; Refai, F. S.; Gopinadhan, S.; Moussa, Y.; Gan, H. H.; Hunashal, Y.; Battaglia, G.; Cipriani, P. G.; Cianca, C.; Rahiman, N.; Kremb, S.; Xie, X.; Pearson, Y. E.; Butterfoss, G. L.; Maizels, R. M.; Esposito, G.; Page, A. P.; Gunsalus, K. C.; Piano, F.
10.1101/2024.12.09.627452 — cell biology — Posted on 2024-12-10
3569 Multi-omic characterization of human sural nerves acrosspolyneuropathies
Heming, M.; Wolbert, J.; Boersch, A.-L.; Thomas, C.; Mausberg, A. K.; Lu, I.-N.; Tietz, J.; Dienhart, F.; Dambietz, C.; Muether, M.; Uerschels, A.-K.; Keyvani, K.; Szepanowski, F.; Eggert, B.; Liebig, K. C.; Doppler, K.; Ueceyler, N.; Aprea, J.; Dahl, A.; Stassart, R.; Fledrich, R.; Wiendl, H.; Sommer, C.; Stettner, M.; Meyer zu Hoerste, G.
10.1101/2024.12.05.627043 — neuroscience — Posted on 2024-12-10
3571 Modulation of Purkinje Cell Inhibition by Stem Cell Factor
Zaman, T.; Lahr, J.; Cherian, S.; Pozzo-Miller, L.; Williams, M. R.
10.1101/2024.12.09.627581 — neuroscience — Posted on 2024-12-10
3574 Gender-specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse Brain
Gumerova, A. A.; Pevnev, G.; Korkmaz, F.; Cheliadinova, U.; Burganova, G.; Vasilyeva, D.; Cullen, L.; Barak, O.; Sultana, F.; Zhou, W.; Sims, S. L.; Laurencin, V.; Frolinger, T.; Kim, S.-M.; Goosens, K. A.; Yuen, T.; Zaidi, M.; Ryu, V.
10.1101/2024.12.09.627541 — neuroscience — Posted on 2024-12-10
3575 Spatial organization of multisensory convergence in mouse isocortex
Patel, K. P.; Ryoo, A. H.-W.; Buice, M.; Mihalas, S.; Tripp, B. P.
10.1101/2024.12.09.627642 — neuroscience — Posted on 2024-12-10
3576 Dysfunctional oscillatory bursting patterns underlie working memory deficits in adolescents with ADHD
Kavanaugh, B.; Vigne, M.; Gamble, I.; Legere, C.; DePamphilis, G.; Acuff, W. L.; Tirrell, E.; Vaughan, N.; Thorpe, R.; Spirito, A.; Jones, S.; Carpenter, L.
10.1101/2024.12.09.627520 — neuroscience — Posted on 2024-12-10
3578 Convincing Evidence of Carnivorous Diet in Alvarezsaurian Dinosaur
WANG, S.; Ding, N.; Ma, W.; Yu, W.; Zheng, T.; Choiniere, J.; Xu, X.
10.1101/2024.12.06.627300 — paleontology — Posted on 2024-12-10
3579 Honest signalling in predator-prey interactions: testing the resource allocation hypothesis
Burdfield-Steel, E.; Ottocento, C.; Furlanetto, M.; Rojas, B.; Nokelainen, O.; Mappes, J.
10.1101/2024.12.06.627197 — evolutionary biology — Posted on 2024-12-10
3581 Extreme lead tolerance in an urban lizard
Blanchette, A.; Su, K.; Frick, A. J.; Karubian, J.; Gunderson, A. R.
10.1101/2024.12.06.626998 — ecology — Posted on 2024-12-10
3583 The two crystal structures of unloaded and cargo-loaded Vacuolar Sorting Receptor 1 lumenal domain (VSR1-Nt) reveal two cargo binding sites and a mechanism of transport.
Borges, R. J.; Eldahshoury, M. K.; Parr, R.; Paul, M.; Fyfe, P.; Nettleship, J.; An, J.; Shah, N.; Loureiro Levada, A. J.; Fontes, M.; Owens, R. J.; Denecke, J.; Quigley, A.; Goldman, A.; POSTIS, V.; Uson, I.; de Marcos Lousa, C.
10.1101/2024.12.07.627339 — plant biology — Posted on 2024-12-10
3585 Auxin and tryptophan trigger common responses in the streptophyte alga Penium margaritaceum
Weijers, D.; Carrillo Carrasco, P.; van Galen, M.; Bronkhorst, J.; Mutte, S.; Sprakel, J.; Hernandez-Garcia, J.
10.1101/2024.12.06.627236 — plant biology — Posted on 2024-12-10
3586 Mapping and characterization of a novel powdery mildew resistance locus (PM2) in Cannabis sativa L.
Seifi, S.; Leckie, K. M.; Giles, I.; O'Brien, T.; MacKenzie, J. O.; Todesco, M.; Rieseberg, L. H.; Baute, G. J.; Celedon, J. M.
10.1101/2024.12.09.627623 — plant biology — Posted on 2024-12-10
3587 Chemical perturbations impacting histone acetylation governcolorectal cancer differentiation
Likasitwatanakul, P.; Li, Z.; Doan, P.; Spisak, S.; Akhouri, K. R.; Liu, Q.; Liow, P.; Lee, S. E.; Chen, D.; Bala, P.; Sahgal, P.; Aitymbayev, D.; Thalappillil, J. S.; Papanastasiou, M.; Hawkins, W.; Carr, S. A.; Park, H.; Cleary, J. M.; Qi, J.; Sethi, N. S.
10.1101/2024.12.06.626451 — cancer biology — Posted on 2024-12-10
3588 UniFORM: Towards Universal Immunofluorescence Normalization for Multiplex Tissue Imaging
Wang, K.; Ait-Ahmad, K.; Kupp, S.; Sims, Z.; Cramer, E.; Sayar, Z.; Yu, J.; Wong, M. H.; Mills, G. B.; Eksi, S. E.; Chang, Y. H.
10.1101/2024.12.06.626879 — bioinformatics — Posted on 2024-12-10
3589 To what extent can life history strategies inform species conservation planning?
Stevenson, E. A.; Lucas, S.; McGowan, P. J. K.; Smallegange, I. M.; Mair, L.
10.1101/2024.12.09.626826 — ecology — Posted on 2024-12-10
3590 Evaluating the utility of amino acid similarity-aware kmers to represent TCR repertoires for classification
Kockelbergh, H.; Evans, S. C.; Brierley, L.; Green, P. L.; Jorgensen, A. L.; Soilleux, E. J.; Fowler, A.
10.1101/2024.12.06.626025 — immunology — Posted on 2024-12-10
3591 Deep analysis of the Major Histocompatibility Complex associations using covariate analysis and haploblocks unravels new mechanisms for the molecular etiology of Elite Control in AIDS
Rahmouni, M.; Le Clerc, S.; Spadoni, J.-L.; Labib, T.; Tison, M.; Medina-santos, R.; Bensussan, A.; Tamouza, R.; Deleuze, J.-F.; Zagury, J.-F.
10.1101/2024.12.07.625684 — immunology — Posted on 2024-12-10
3592 Hormetic curve of dietary mono- and disaccharide content determines weight gain, gut microbiota composition and cognitive ability in mice
Bartochowski, P.; Chwastek, J.; Zglinicki, B.; Pietrzyk, O.; Olech-Kochanczyk, G.; Szewc, M.; Bartelik, A.; Torres, J. C.; Karpinski, A.; Jaholkowski, P.; Klejman, A.; Kochanczyk, M.; Bulska, E.; Galecka, M.; Kursa, M.; Konopka, A.; Kiryk, A.; Konopka, W.
10.1101/2024.12.06.625641 — neuroscience — Posted on 2024-12-10
3593 Brain-body circuit by which midbrain dopamine neuronal activity modulates splenic immunity
Gopinath, A.; Apicella, A.; Smith, A. R.; Bertero, A.; Freedman, E.; Hornstein, L.; Wood, L.; Ciupe, H.; Booth, D.; Campos, S.; Soundara, N.; Purich, D. L.; Trevizan-Bau, P.; Reznikov, L.; Urs, N. M.; Guryanova, O.; Wesson, D. W.; Khoshbouei, H.
10.1101/2024.12.05.625471 — neuroscience — Posted on 2024-12-10
3595 Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway
Barry, A. M.; Sondermann, J. R.; Lesnak, J. B.; Xian, F.; Franco-Enzastiga, U.; O'Brien, J. A.; Varela, D. G.; Schackmuth, M. K.; Shiers, S.; Price, T. J.; Schmidt, M.
10.1101/2024.12.06.626968 — neuroscience — Posted on 2024-12-10
3597 Identification of Gene Targets for the Sprouting Inhibitor CIPC
Grand, T. M.; Pitman, J. K.; Williams, A. L.; Smith, L. M.; Fleming, A. J.
10.1101/2024.12.07.626028 — plant biology — Posted on 2024-12-10
3599 Matrix Metalloproteinase-2 as a novel regulator of glucose utilization by adipocytes
Lempicki, M. D.; Garrigues, R. J.; Zeczycki, T. N.; Gracia, B. L.; Harris, T. E.; Meher, A. K.
10.1101/2024.12.09.626845 — pathology — Posted on 2024-12-10
3600 Tumor break load quantitates structural variant-associated genomic instability with biological and clinical relevance across cancers
Lakbir, S.; de Wit, R.; de Bruijn, I.; Kundra, R.; Madupuri, R.; Gao, J.; Schultz, N.; Meijer, G. A.; Heringa, J.; Fijneman, R. J. A.; Abeln, S.
10.1101/2024.12.08.626771 — cancer biology — Posted on 2024-12-10
3601 Self organisation of invasive breast cancer driven by the interplay of active and passive nematic dynamics
Gottheil, P.; Bhattacharyya, S.; Lettl, K.; Friedrich, P.; Roth, K.; Rivera-Moreno, S.; Merkel, M.; Aktas, B.; Sauer, I.; Daneshgar, A.; Wieland, J.; Kubitschke, H.; Wegscheider, A.-S.; Yeomans, J. M.; Kaes, J. A.
10.1101/2024.12.09.626295 — biophysics — Posted on 2024-12-10
3602 HIPSTR: highest independent posterior subtree reconstruction in TreeAnnotator X
Baele, G.; Carvalho, L. M.; Brusselmans, M.; Dudas, G.; Ji, X.; McCrone, J. T.; Lemey, P.; Suchard, M. A.; Rambaut, A.
10.1101/2024.12.08.627395 — bioinformatics — Posted on 2024-12-10
3605 Rapid kinetics of H+ transport by membrane pyrophosphatase: evidence for a direct-coupling mechanism
Anashkin, V. A.; Bogachev, A. V.; Serebryakova, M. V.; Zavyalova, E. G.; Bertsova, Y. V.; Baykov, A. A.
10.1101/2024.12.06.627301 — biochemistry — Posted on 2024-12-10
3609 Comparison of whole-genome assemblies of European river lamprey (Lampetra fluviatilis) and brook lamprey (Lampetra planeri)
Torresen, O. K.; Garmann-Aarhus, B.; Hoff, S. N. K.; Jentoft, S.; Svensson, M.; Schartum, E.; Tooming-Klunderud, A.; Skage, M.; Krabberod, A.; Vollestad, L. A.; Jakobsen, K. S.
10.1101/2024.12.06.627158 — genomics — Posted on 2024-12-10
3611 Diverging repeatomes in holoparasitic Hydnoraceae uncover a playground of genome evolution
Kim, W.; Schmidt, N.; Jost, M.; Mkala, E. M.; Winkler, S.; Hu, G.-W.; Heitkam, T.; Wanke, S.
10.1101/2024.12.09.626742 — evolutionary biology — Posted on 2024-12-10
3612 Good fire: quantifying the beneficial ecosystem work of western U.S. wildfires (2010-2020)
Balch, J. K.; McIntosh, T. L.; Ilangakoon, N. T.; Cummins, K.; Varner, J. M.; Hansen, W. D.; Marquis, K. D.; Raymond, C. L.; Harvey, B. J.; Platt, R. V.
10.1101/2024.12.06.627082 — ecology — Posted on 2024-12-10
3613 Cobalt induces the set-up of new structural network in river biofilms: Impairment of autotrophic-heterotrophic coupling.
Gourgues, S.; Goni-Urriza, M.; Baldoni-Andrey, P.; Bagger Gurieff, N.; Gelber, C.; Le Faucheur, S.
10.1101/2024.12.07.625411 — ecology — Posted on 2024-12-10
3615 Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSCs-derived myogenic progenitor cells
Caputo, L.; Stamenkovic, C.; Tierney, M. T.; Falzarano, M. S.; Bassel-Duby, R.; Ferlini, A.; Olson, E. N.; Puri, P. L. N.; Sacco, A.
10.1101/2024.12.09.624203 — cell biology — Posted on 2024-12-10
3618 A novel menthol-DCMU bleaching method for foraminifera: Generating aposymbiotic hosts for symbiosis research
Schmidt, C.; Puerto Rueda, D. N.; Nusser, M.; Oakley, C. A.; Pochon, X.; Stuhr, M.; Raposo, D. S.; Davy, S. K.
10.1101/2024.12.09.627035 — cell biology — Posted on 2024-12-10
3619 Cannabinoid inhibition of mechanosensitive K+ channels
Docter, T.; Sorum, B.; Deshmane, R.; Doubravsky, C.; Brohawn, S. G.
10.1101/2024.12.09.627564 — neuroscience — Posted on 2024-12-10
3620 Competition between glycine and GABAA receptors for gephyrin controls their equilibrium populations at inhibitory synapses
Kostrz, D.; Maynard, S. A.; Schulte, C.; Laurent, F.; Masson, J.-B.; Maric, H. M.; Gosse, C.; TRILLER, A.; Strick, T. R.; Specht, C. G.
10.1101/2024.12.09.627587 — neuroscience — Posted on 2024-12-10
3621 Mobile Human Brain Imaging using Functional Ultrasound
Soloukey, S.; Verhoef, L.; Mastik, F.; Brown, M.; Springeling, G.; Generowicz, B.; Satoer, D.; Dirven, C.; Smits, M.; Hunyadi, B.; Koekkoek, B.; Vincent, A.; De Zeeuw, C. I.; Kruizinga, P.
10.1101/2024.12.08.627337 — neuroscience — Posted on 2024-12-10
3624 Allee effects, spawning asynchrony, and mixed reproductive modes in a common mass spawning coral
Ricardo, G. F.; Doropoulos, C.; Babcock, R. C.; Adam, A. A. S.; Buccheri, E.; Robledo, N.; Uribe-Palomino, J.; Mumby, P. J.
10.1101/2024.12.06.627154 — ecology — Posted on 2024-12-09
3625 Vocal species are more central in Eastern Himalayan Mixed-Species bird flocks
Gupta, S.; Bharadwaj, A.; Bhat, A.; Thapa, A.; Biswakarma, A.; Tamang, B.; Munda, B.; Biswakarma, B.; Pradhan, D.; Tamang, D.; Rai, M.; Rai, R.; Rai, S.; Srinivasan, U.
10.1101/2024.12.06.626929 — ecology — Posted on 2024-12-09
3628 Controlled 'out-of-season' spawning of reef-forming corals in aquaria using offset environmental profiles
Koukoumaftsis, L. P.; Salmon, M.; Everson, G. A.; Hughes, D. J.; Varkey, D.; Heyward, A. J.; Severati, A.; Humphrey, C.
10.1101/2024.12.05.626918 — ecology — Posted on 2024-12-09
3631 Essential sterols from engineered yeast prevent honeybee colony population decline
Moore, E. V.; Teixeira de Sousa, R.; Felsinger, S.; Arnesen, J. A.; Dyekjaer, J. D.; Farman, D. I.; Goncalves, R.; Stevenson, P. C.; Borodina, I.; Wright, G. A.
10.1101/2024.12.09.627483 — synthetic biology — Posted on 2024-12-09
3632 Enantioselective photoenzymatic C(sp3)-H functionalization via single-electron oxidation of carbanions
Zhu, J.; Zhang, Q.; Gu, T.; Chen, B.; Ma, M.; Wang, X.; Liu, X.; Ma, M.; Wang, B.; Wang, Y.
10.1101/2024.12.08.627421 — biochemistry — Posted on 2024-12-09
3633 Structural Determinants of Mucins in Influenza Virus Inhibition: The Synergistic Role of Sialylated Glycans and Molecular Size
Butnarasu, C.; Safferthal, M.; Thomas, J.; Povolotsky, T. L.; Diehn, R.; Fentker, K.; Mertins, P.; Pagel, K.; Lauster, D. C.
10.1101/2024.12.09.627521 — biochemistry — Posted on 2024-12-09
3634 Kinetic and structure-based comparisons of silent and stimulatory flagellin interactions with TLR5
Bell, M. E. W.; Haag, M.; Clasen, S. J.; Boecker, M. A.; Maksymenko, K.; Koch, I.; Hipp, K.; Hartmann, M.; Weir, J. R.; Merino, F.; Ley, R. E.
10.1101/2024.12.09.627598 — biochemistry — Posted on 2024-12-09
3635 The CECR2 bromodomain displays distinct binding modes to select for acetylated histone proteins versus non-histone ligands.
Phillips, M.; Cook, E. D.; Marunde, M. R.; Tonelli, M.; Khan, L.; Hendrickson, A.; Lignos, J. M.; Stein, J. L.; Stein, G. S.; Frietze, S.; Demeler, B.; Glass, K. C.
10.1101/2024.12.09.627393 — biochemistry — Posted on 2024-12-09
3638 Rates of evolution differ between cell types identified by single-cell RNAseq in threespine stickleback
Rodgers, M. L.; Subramanian, S.; Fuess, L. E.; He, W.; Scarpino, S. V.; Roth-Monzon, A.; Jeffries, D.; Seignon, M.; Milligan-McClellan, K.; Carrier, R.; Steinel, N. C.; Bolnick, D. I.
10.1101/2024.12.06.627160 — evolutionary biology — Posted on 2024-12-09
3639 Transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers
Fettweis, G.; Wagh, K.; Stavreva, D. A.; Jimenez-Panizo, A.; Kim, S.; Lion, M.; Alegre-Marti, A.; Johnson, T. A.; Ball, D. A.; Karpova, T. S.; Upadhyaya, A.; Vertommen, D.; Fernandez-Recio, J.; Estebanez-Perpina, E.; Dequiedt, F.; Hager, G. L.
10.1101/2024.12.09.627537 — molecular biology — Posted on 2024-12-09
3642 Genomic and proteomic characterization of sulfate-reducing symbionts of gutless marine annelids
D'Angelo, G.; Kleiner, M.; Mankowski, A.; Cifuentes-Anticevic, J.; Kroeber, E.; Violette, M.; De Anda, V.; Dubilier, N.; Liebeke, M.
10.1101/2024.12.09.627487 — microbiology — Posted on 2024-12-09
3644 The Quorum Sensing regulated sRNA Lrs1 is involved in the adaptation to low iron in Pseudomonas aeruginosa
Panagiotopoulou, D.; Catalan, N. R.; Wilcox, M.; Halliday, N.; Pantalone, P.; Lazenby, J.; Camara, M.; Heeb, S.
10.1101/2024.12.09.627364 — microbiology — Posted on 2024-12-09
3649 XRN1 supplies free nucleotides to feed alphavirus replication
Ruscica, V.; Iselin, L.; Hull, R.; Embarc-Buh, A.; Narayanan, S.; Palmalux, N.; Raut, N.; Gu, Q.; Chen, H.; Noerenberg, M.; de Laurent, Z. R.; Joseph, J.; Noble, M.; Igreja, C.; Robertson, D. L.; Hughes, J.; Mohammed, S.; Pelechano, V.; Davis, I.; Castello, A.
10.1101/2024.12.09.625895 — biochemistry — Posted on 2024-12-09
3650 Regulation of XPG-DNA damage binding dynamics by pre- and post-incision nucleotide excision repair factors and EXO1
Muniesa-Vargas, A.; Ribeiro-Silva, C.; Geverts, B.; Davo-Martinez, C.; van de Grint, J.; Ganpat, M.; Thijssen, K. L.; Pothof, J.; Houtsmuller, A.; Theil, A. F.; Vermeulen, W.; Lans, H.
10.1101/2024.12.06.627128 — genetics — Posted on 2024-12-09
3655 Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
Zhang, D. X.; Isupov, M. N.; Davies, R. M.; Schwarzer, S.; McLaren, M.; Stuart, W. S.; Gold, V. A. M.; Oksanen, H. M.; Quax, T. E. F.; Daum, B.
10.1101/2024.12.09.627619 — microbiology — Posted on 2024-12-09
3659 Defining a highly conserved B cell epitope in the receptor binding motif of SARS-CoV-2 spike glycoprotein
Malladi, S. K.; Jaiswal, D.; Ying, B.; Alsoussi, W.; Darling, T.; Dadonaite, B.; Civljak, A.; Horvath, S.; Zhou, J.; Kim, W.; Turner, J.; Schmitz, A.; Han, F.; Scheaffer, S.; Farnsworth, C.; Nachbagauer, R.; Nestorova, B.; Chalkias, S.; Klebert, M.; Edwards, D.; Paris, R.; Strnad, B.; Middleton, W.; OHalloran, J.; Presti, R.; Bloom, J. D.; Boon, A. C. M.; Diamond, M. S.; Bajic, G.; Ellebedy, A. H.
10.1101/2024.12.06.625234 — immunology — Posted on 2024-12-09
3664 Nanoscale Optical Imaging, Reconstruction, and Spatial Analysis of Whole Mouse Glomeruli
Ali, A.; Liu, Z.; Ye, K.; Guan, Y.; Chen, S.; Liu, T.; Guo, Z.; Wong, M. K.; Vasquez, P.; Poudel, C.; Mustonen, B. C.; Eng, D.; Pippin, J.; Shankland, S. J.; Wang, S.; Vaughan, J. C.
10.1101/2024.10.31.620364 — physiology — Posted on 2024-12-09
3668 Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation
Guayasamin, M.; Depaauw-Holt, L. R.; Adedipe, I. I.; Ghenissa, O.; Vaugeois, J.; Duquenne, M.; Rogers, B.; Latraverse-Arquilla, J.; Peyrard, S.; Bosson, A.; Murphy-Royal, C.
10.1101/2022.12.11.519598 — neuroscience — Posted on 2024-12-09
3671 Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis
Gutierrez-Jimenez, E.; Rasmussen, P. M.; Mikkelsen, I. K.; Kura, S.; Fruekilde, S. K.; Hansen, B.; Bordoni, L.; Carlsen, J.; Palmfeldt, J.; Boas, D. A.; Sakadzic, S.; Vinogradov, S. A.; El Khatib, M.; Ramos-Cejudo, J.; Wied, B.; Leduc-Galindo, D.; Canepa, E.; Mar, A. C.; Gamallo-Lana, B.; Fossati, S.; Ostergaard, L.
10.1101/2024.08.22.609091 — neuroscience — Posted on 2024-12-09
3672 Multi-scale parameterization of neural rhythmicity with lagged Hilbert autocoherence
Zhang, S.; Szul, M. J.; Papadopoulos, S.; Massera, A.; Rayson, H.; Bonaiuto, J. J.
10.1101/2024.12.05.627017 — neuroscience — Posted on 2024-12-09
3676 Localized Delivery of Growth Factors from Microparticles Modulate Osteogenic and Chondrogenic Gene Expression in Growth Factor-dependent Manner in an ex vivo Chick Embryonic Bone Model.
Rashidi, H.; Cox, H. C.; Qutachi, O.; Moulding, D.; White, L. J.; Smith, E. L.; Kanczler, J. M.; Rojo, L.; Rotherham, M.; Henstock, J. R.; Stevens, M. M.; El Haj, A. J.; Orrefo, R. O. C.; Shakesheff, K. M.; Rose, F. R. A. J.
10.1101/2024.12.05.627026 — bioengineering — Posted on 2024-12-09
3677 Dysfunctional mechanotransduction regulates the progression of PIK3CA-driven vascular malformations
Aw, W. Y.; Sawhney, A.; Rathod, M.; Whitworth, C. P.; Doherty, E. L.; Madden, E.; Lu, J.; Westphal, K.; Stack, R. N.; Polacheck, W. J.
10.1101/2024.08.22.609165 — bioengineering — Posted on 2024-12-09
3681 Repertoire-based mapping and time-tracking of helper T cell subsets in scRNA-Seq
Lukyanov, D. K.; Kriukova, V. V.; Ladell, K.; Shagina, I. A.; Staroverov, D. B.; Minasian, B.; Fedosova, A. S.; Shelyakin, P.; Suchalko, O. N.; Komkov, A.; Blagodatskikh, K. A.; Miners, K. L.; Britanova, O. V.; Franke, A.; Price, D. A.; Chudakov, D. M.
10.1101/2023.10.24.563704 — immunology — Posted on 2024-12-09
3682 Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation.
Bathla, S.; Datta, D.; Bolat, D.; Woo, E.; Duque, A.; Arellano, J.; Arnsten, A.; Nairn, A. C.
10.1101/2024.12.05.626721 — neuroscience — Posted on 2024-12-09
3684 Divalent siRNA for prion disease
Gentile, J. E.; Corridon, T. L.; Serack, F. E.; Echeverria, D.; Kennedy, Z. E.; Gallant-Behm, C. L.; Hassler, M. R.; Kinberger, G.; Kamath, N. G.; Lian, Y.; Gross, K. Y.; Miller, R.; DeSouza-Lenz, K.; Howard, M.; Guzman, K.; Chan, N.; Curtis, D. T.; Fettes, K.; Lemaitre, M.; Cappon, G.; Jackson, A. L.; Yamada, K.; Alterman, J. F.; Coffey, A. A.; Minikel, E. V.; Khvorova, A.; Vallabh, S. M.
10.1101/2024.12.05.627039 — neuroscience — Posted on 2024-12-09
3687 Enzyme-Regulated Non-Thermal Fluctuations Enhance Ligand Diffusion and Receptor-Mediated Endocytosis
Nividha, ; Maiti, A.; Parihar, K.; Chakraborty, R.; Agarwala, P.; Sasmal, D. K.; Radhakrishnan, R.; Bhatia, D.; Dey, K. K.
10.1101/2024.12.05.627033 — biophysics — Posted on 2024-12-09
3689 deepBlastoid: A Deep Learning-Based High-Throughput Classifier for Human Blastoids Using Brightfield Images with Confidence Assessment
Fan, Z.; Li, Z.; Jin, Y.; Chandrasekaran, A. P.; Shakir, I. M.; Zhang, Y.; Siddique, A.; Wang, M.; zhou, X.; Tian, Y.; Wonka, P.; Li, M.
10.1101/2024.12.05.627041 — developmental biology — Posted on 2024-12-09
3690 Uncoupling the functional roles of Coronavirus Nsp1
Baeumlin, E.; Andenmatten, D.; Luginbuehl, J.; Lalou, A.; Schwaller, N.; Karousis, E. D.
10.1101/2024.08.05.606569 — molecular biology — Posted on 2024-12-09
3691 Multi-scale parameterization of neural rhythmicity with lagged Hilbert autocoherence
Zhang, S.; Szul, M. J.; Papadopoulos, S.; Massera, A.; Rayson, H.; Bonaiuto, J. J.
10.1101/2024.12.05.627017 — neuroscience — Posted on 2024-12-09
3693 The monomer/dimer switch modulates the activity of plant adenosine kinase
Kopecny, D. J.; Vigouroux, A.; Belicek, J.; Kopecna, M.; Koncitikova, R.; Friedecka, J.; Mik, V.; Humplik, J. F.; Le Berre, M.; Plancqueel, S.; Strnad, M.; von Schwartzenberg, K.; Novak, O.; Morera, S.; Kopecny, D.
10.1101/2024.12.05.626941 — plant biology — Posted on 2024-12-09
3695 Single-molecule biodosimetry
Lamontagne, M.; Newell, S. M.; Pazos, I.; Tosh, R.; Polf, J.; Zwolak, M.; Robertson, J. W. F.
10.1101/2024.12.05.627019 — biophysics — Posted on 2024-12-09
3697 BioMedGraphica: An All-in-One Platform for Biomedical Prior Knowledge and Omic Signaling Graph Generation
Zhang, H.; Liang, S.; Xu, T.; Li, W.; Huang, D.; Dong, Y.; Li, G.; Miller, J. P.; Goedegebuure, S. P.; Sardiello, M.; Cooper, J. D.; Buchser, W.; Dickson, P.; Fields, R. C.; Cruchaga, C.; Chen, Y.; Province, M.; Payne, P. R.; Li, F.
10.1101/2024.12.05.627020 — bioinformatics — Posted on 2024-12-09
3699 Impact of Mycotoxins and Glyphosate residue on the Gut Microbiome and Resistome of European Fallow Deer
Toth, A. G.; Nagy, S. A.; Lakatos, I.; Solymosi, N.; Stagel, A.; Paholcsek, M.; Posta, K.; Ferenczi, S.; Szoke, Z.
10.1101/2024.12.05.626988 — genomics — Posted on 2024-12-09
3700 Concerted loss of micro-RNAs uncovers multi-level restructuring of gene regulation in rodents
Langschied, F.; Leisegang, M. S.; Guenther, S.; Hahner, F.; Brandes, R. P.; Ebersberger, I.
10.1101/2024.12.05.627021 — genetics — Posted on 2024-12-09
3701 Structural and evolutionary features of red algal UV sex chromosomes
Lipinska, A. P.; Cossard, G.; Epperlein, P.; Woertwein, T.; Molenier, C.; Godfroy, O.; Carli, S.; Ayres, L.; Lavaut, E.; Marchi, F.; Mauger, S.; Destombe, C.; Oliveira, M. C.; Plastino, E.; Krueger-Hadfield, S.; Guillemin, M.-L.; Valero, M.; Coelho, S. M.
10.1101/2024.12.05.626989 — evolutionary biology — Posted on 2024-12-09
3702 Large effect life-history genomic regions are associated with functional morphological traits in Atlantic salmon
Aykanat, T.; Debes, P. V.; Jansouz, S.; Gueguen, L.; Erkinaro, J.; Pritchard, V. L.; Primmer, C. R.; Bolstad, G. H.
10.1101/2024.12.05.627014 — ecology — Posted on 2024-12-09
3707 Ligand Identification in CryoEM and X-ray Maps Using Deep Learning
Karolczak, J.; Przybylowska, A.; Szewczyk, K.; Taisner, W.; Heumann, J. M.; Stowell, M. H. B.; Nowicki, M.; Brzezinski, D.
10.1101/2024.08.27.610022 — bioinformatics — Posted on 2024-12-09
3710 Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration
Forman-Rubinsky, R.; Feng, W.; Schlegel, B. T.; Paul, A.; Zuppo, D.; Kedziora, K.; Beer-Stolz, D.; Watkins, S.; Rajasundaram, D.; Li, G.; Tsang, M.
10.1101/2024.12.05.626917 — developmental biology — Posted on 2024-12-09
3711 MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore
Massoni, S. C.; Evans, N. J.; Hantke, I.; Fenton, C.; Torpey, J. H.; Collins, K. M.; Krysztofinska, E. M.; Muench, J. H.; Thapaliya, A.; Martinez-Lumbreras, S.; Martin, S. H.; Slater, C.; Wang, X.; Fekade, R.; Obwar, S.; Yin, S.; Vazquez, A.; Prior, C. B.; Turgay, K.; Isaacson, R. L.; Camp, A. H.
10.1101/2024.03.02.583065 — microbiology — Posted on 2024-12-09
3712 Humoral correlate of vaccine-mediated protection from tuberculosis identified in humans and non-human primates
Kelkar, N. S.; Curtis, N. C.; Lahey, T. P.; Wieland-Alter, W.; Stout, J. E.; Larson, E. C.; Jauro, S.; Scanga, C. A.; Darrah, P. A.; Roederer, M.; Seder, R. A.; von Reyn, C. F.; Lee, J.; Ackerman, M. E.
10.1101/2024.12.05.627012 — immunology — Posted on 2024-12-09
3713 EEG data quality in large scale field studies in India and Tanzania
Vianney, S. J.-M.; Swaminathan, S.; Newson, J. J.; Parameshwaran, D.; Subramaniyam, N. P.; Roy, S. S.; Machunda, R.; Sapuli, A.; Pramanik, S.; Kumar, J. V. A.; Tiwari, P.; Mathuram, G. N. M.; Bembeleza, L. B.; Laiser, J. P.; Luhwago, W. J.; Maduka, T. P.; Mollel, J. O.; Mollel, N. G.; Mugizi, A. A.; Mwamakula, I. L.; Rweyemamu, R. E.; Samweli, U. F.; Simpito, J. I.; Shirima, K. E.; Anbalagan, A.; Arumugam, S. K.; Dhanapal, V.; Gunasekaran, K.; Kashyap, N.; Kumar, D.; Pandey, D.; Pandey, P.; Panneerselvam, A.; Rai, S.; Rajendran, P.; Sekar, S.; Sivalingam, O.; Soni, P.; Soni, P.; Thiagarajan, T
10.1101/2024.12.05.626951 — neuroscience — Posted on 2024-12-09
3714 More or fewer latent variables in the high-dimensional data space? That is the question
Vaccari, F. E.; Diomedi, S.; Bettazzi, E.; Filippini, M.; De Vitis, M.; Hadjidimitrakis, K.; Fattori, P.
10.1101/2024.11.28.625854 — neuroscience — Posted on 2024-12-09
3716 Structural, genetic, and adaptive basis of superhydrophobicity in rice leaves
Hiraiwa, A.; Aiga, S.; Zhu, T.; Mimura, M.; Yoshikawa, T.; Sato, Y.; Itoh, J.-i.
10.1101/2024.12.05.626993 — plant biology — Posted on 2024-12-09
3717 High resolution kinematic approach for quantifying impaired mobility of dystrophic zebrafish larvae
Widrick, J. J.; Lambert, M. R.; de Souza Leite, F.; Jung, Y. L.; Park, J.; Conner, J. R.; Lee, E. A.; Beggs, A. H.; Kunkel, L. M.
10.1101/2024.12.05.627004 — physiology — Posted on 2024-12-09
3720 NicheTrans: Spatial-aware Cross-omics Translation
Wang, Z.; Lin, S.; Zou, Q.; CUI, Y.; Han, C.; Li, Y.; Li, J.; Zhao, Y.; Gao, R.; Song, J.; Yuan, Z.
10.1101/2024.12.05.626986 — bioinformatics — Posted on 2024-12-09
3723 A Novel Taxonomic Database for eukaryotic Mitochondrial Cytochrome Oxidase subunit I Gene (eKOI): Enhancing taxonomic resolution at community-level in metabarcoding analyses
Gonzalez-Miguens, R.; Galvez-Morante, A.; Skamnelou, M.; Anto, M.; Casacuberta, E.; Richter, D. J.; Vaulot, D.; del Campo, J.; Ruiz-Trillo, I.
10.1101/2024.12.05.626972 — ecology — Posted on 2024-12-09
3725 Accessing the specific capacity of TIL-derived CD8 T-cells to suppress tumor recurrence in resectable HBV-HCC patients
Kah, J.; Staffeldt, L.; Mattert, G.; Volz, T.; Schulze, K.; Heumann, A.; Voss, M.; Hoell, M. C.; Goebel, M.; Peine, S.; Dandri, M.; Lueth, S.
10.1101/2024.12.05.626571 — immunology — Posted on 2024-12-09
3731 Time-of-day related fluctuations of self-belief formation
Mayer, A. V.; Schröder, A.; Czekalla, N.; Müller-Pinzler, L.; Rosenbusch, L.; Paulus, F. M.; Oster, H.; Sayk, C.; Kammerer, M.; Wilhelm-Groch, I.; Krach, S.
10.1101/2024.12.05.627011 — neuroscience — Posted on 2024-12-09
3732 ARID1A-induced transcriptional reprogramming rewires signalling responses to drug treatment in melanoma
Barker, C. G.; Sharma, S.; Santos, A. M.; Nikolakopoulos, K. S.; Velentzas, A. D.; Voellmy, F. I.; Minia, A.; Pliaka, V.; Altelaar, M.; Wright, G. J.; Alexopoulos, L. G.; Stravopodis, D. J.; Petsalaki, E.
10.1101/2024.12.05.626952 — systems biology — Posted on 2024-12-09
3734 Chasing non-existent microRNAs in cancer
Orang, A.; Warnock, N. I.; Migault, M.; Dredge, B. K.; Bert, A. G.; Bracken, J. M.; Gregory, P. A.; Pillman, K. A.; Goodall, G. J.; Bracken, C. P.
10.1101/2024.12.05.626946 — cancer biology — Posted on 2024-12-09
3735 CCR1 inhibition sensitizes multiple myeloma cells toglucocorticoid therapy
Luyckx, B.; Van Trimpont, M.; Declerck, F.; Staessens, E.; Verhee, A.; T'Sas, S.; Eyckerman, S.; Offner, F.; Van Vlierberghe, P.; Goossens, S.; Clarisse, D.; De Bosscher, K.
10.1101/2024.12.05.626954 — cancer biology — Posted on 2024-12-09
3738 Integrated population clustering and genomic epidemiology with PopPIPE
McHugh, M. P.; Horsfield, S. T.; von Wachsmann, J.; Toussaint, J.; Pettigrew, K. A.; Czarniak, E.; Evans, T. J.; Leanord, A.; Tysall, L.; Gillespie, S. H.; Templeton, K. E.; Holden, M. T. G.; Croucher, N. J.; Lees, J. A.
10.1101/2024.12.05.626978 — bioinformatics — Posted on 2024-12-09
3739 Engineered coagulation factor VIII with enhanced secretion and coagulation potential for hemophilia A gene therapy
Kashiwakura, Y.; Nakajima, Y.; Horinaka, K.; Lopes, T. J. d. S.; Furuta, Y.; Yamaguchi, Y.; Baatartsogt, N.; Hayakawa, M.; Katakai, Y.; Uchiyama, S.; Nureki, O.; Nogami, K.; Ohmori, T.
10.1101/2024.12.05.626963 — bioengineering — Posted on 2024-12-09
3740 Biofabrication of a filtration barrier by integrating electrospun membranes and flow in a glomerular co-culture
mussoni, c.; Rederer, A.; Stepanenko, V.; Wuerthner, F.; Stahlhut, P.; Groll, J.; Schiffer, M.; Ahmad, T.; Mueller-Deile, J.
10.1101/2024.12.05.626949 — bioengineering — Posted on 2024-12-09
3741 Spatially-resolved molecular sex differences at single cell resolution in the adult human hypothalamus
Mulvey, B.; Wang, Y.; Divecha, H. R.; Bach, S. V.; Montgomery, K. D.; Cinquemani, S.; Chandra, A.; Du, Y.; Miller, R. A.; Kleinman, J. E.; Page, S. C.; Hyde, T. M.; Martinowich, K.; Hicks, S. C.; Hansen, K. D.; Maynard, K. R.
10.1101/2024.12.07.627362 — genomics — Posted on 2024-12-09
3742 Bridging species boundaries: eDNA and genetic analysis reveal hybrid settlement at the very end of American eel distribution
Jacobsen, M. W.; Nygaard, R.; Frankowski, J.; Tengstedt, A. N. B.; Nielsen, J.; Hansen, M. M.; Hedeholm, R.; Retzel, A.; Hedal, I.; Urban, P.; Jorgensen, C. G.; Larsen, R. S.; Maggini, S.; Rask, P.; Nielsen, E. E.
10.1101/2024.12.05.626534 — genetics — Posted on 2024-12-09
3744 Identification and Targeting of Regulators of SARS-CoV-2-Host Interactions in the Airway Epithelium.
Dirvin, B. G.; Noh, H.; Tomassoni, L.; Cao, D.; Zhou, Y.; Ke, X.; Qian, J.; Jangra, S.; Schotsaert, M.; Garcia-Sastre, A.; Karan, C.; Califano, A.; Cardoso, W. V.
10.1101/2024.10.11.617898 — cell biology — Posted on 2024-12-09
3746 Identification of disease-specific vulnerability states at the single-cell level
D'Antuono, M.; Sharp, M.; Chowdary, R.; Ivan, M. E.; Komotar, R. J.; Suter, R. K.; Ayad, N. G.
10.1101/2024.12.04.626873 — cancer biology — Posted on 2024-12-09
3748 Constant-pH MD Simulations of Lipids
Trollmann, M. F. W.; Rossetti, P.; Böckmann, R. A.
10.1101/2024.12.06.627182 — biophysics — Posted on 2024-12-09
3750 New insight into erythema reduction induced by quercetin metal ions chelates
Bolano Alvarez, A.; Arvesen, K. B.; Bjerring, P.; Hjuler, K. F.; Petersen, S. B.
10.1101/2024.12.04.626931 — biophysics — Posted on 2024-12-09
3755 Magnetically induced magnetosome chain (MAGiC):A biogenic magnetic-particle-imaging tracer with high performance and navigability
Li, L.; Zhao, C.; Zhao, Z.; Han, D.; Liao, Y.; Liu, Y.; Liu, S.; Jia, X.; Tian, J.; Liu, Q.; Feng, X.; Tian, J.
10.1101/2024.12.04.626925 — bioengineering — Posted on 2024-12-09
3757 Identification of potent HSV antivirals using 3D bioprinted human skin equivalents
Ellison, S. T.; Hayman, I.; Derr, K.; Derr, P.; Frebert, S.; Itkin, Z.; Shen, M.; Jones, A.; Olson, W.; Corey, L.; Wald, A.; Johnston, C. M.; Fong, Y.; Ferrer, M.; Zhu, J.
10.1101/2024.12.04.626896 — bioengineering — Posted on 2024-12-09
3758 Differing genetics of saline and cocaine self administration in the hybrid mouse diversity panel
Khan, A. H.; Bagley, J. R.; LaPierre, N. R. S.; Gonzalez-Figueroa, C.; Spencer, T. C.; Choudhury, M.; Xiao, X. G.; Eskin, E.; Jentsch, J. D.; Smith, D. J.
10.1101/2024.12.04.626933 — genetics — Posted on 2024-12-09
3759 Unveiling the diversity, transmission, and zoonotic potential of microbes in true insectivores
Li, H.; Huang, Z. Y. X.; Lan, J.; Hu, L.; Wei, X.; Wang, Y.; Li, X.; Li, Y.; Becker, D.; Wei, F.; Xu, Y.
10.1101/2024.12.04.626791 — ecology — Posted on 2024-12-09
3760 Transcriptomic Landscape and Immune Microenvironment AroundWound Bed Define Regenerative versus Non-regenerative Outcomesin Mouse Digit Amputation
Prabahar, A.; Chamberlain, C.; Vanderby, R.; Murphy, W.; Dangelo, W.; Mangesh, K.; Brown, B.; Mazumder, B.; Badylak, S.; Jiang, P.
10.1101/2024.12.04.626910 — developmental biology — Posted on 2024-12-09
3761 Functional and epitope specific monoclonal antibody discovery directly from immune sera using cryoEM
Ferguson, J. A.; Raghavan, S. S. R.; Pena Alzua, G.; Bhavsar, D.; Huang, J.; Rodriguez, A. J.; Torres, J. L.; Bottermann, M.; Han, J.; Krammer, F.; Batista, F. D.; Ward, A. B.
10.1101/2024.12.06.627063 — immunology — Posted on 2024-12-09
3762 Structure of a zoonotic H5N1 hemagglutinin reveals a receptor-binding site occupied by an auto-glycan
Morano, N. C.; Guo, Y.; Becker, J. E.; Li, Z.; Yu, J.; Ho, D. D.; Shapiro, L.; Kwong, P. D.
10.1101/2024.12.06.626699 — immunology — Posted on 2024-12-09
3763 Age-related remodeling of the glycocalyx drives T cell exhaustion
Zhang, H.; Tsui, C. K.; Castillo, J. G.; Evangelista, A. C.; Kim, E. J. Y.; Joe, L. K.; Twells, N.; Robey, E. A.; Mahal, L. K.; DuPage, M. J.; Dillin, A.
10.1101/2024.12.06.627213 — immunology — Posted on 2024-12-09
3766 Top-down attention and Alzheimer's pathology impact cortical selectivity during learning,influencing episodic memory in older adults
Sheng, J.; Trelle, A. N.; Romero, A.; Park, J.; Tran, T. T.; Sha, S.; Andreasson, K.; Wilson, E. N.; Mormino, E.; Wagner, A. D.
10.1101/2024.12.04.626911 — neuroscience — Posted on 2024-12-09
3768 Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT
Ahn, R.; D'Souza, A. D.; Long, L.; Cui, Y.; Burgenske, D.; Bakken, K. K.; Ott, L. L.; Carlson, B. L.; Zhou, G.; Yaron-Barir, T. M.; Kohale, I. N.; Whittaker, C. A.; Flower, C. T.; Wyckoff, J.; Tuma, A.; Johnson, J. L.; Sarkaria, J.; White, F. M.
10.1101/2024.12.04.626717 — systems biology — Posted on 2024-12-09
3770 Shared and distinct adaptations to early-life exercise training based on inborn fitness
Sadler, D. G.; Treas, L.; Barre, M.; Ross, T.; Sikes, J. D.; Zhong, Y.; Britton, S. L.; Koch, L.; Wankhade, U.; Borsheim, E.; Porter, C.
10.1101/2024.12.04.626895 — physiology — Posted on 2024-12-09
3771 Microvascular preservation and cardiomyocyte hyperplasia underlie adaptive right ventricular development in congenital heart disease-associated pulmonary arterial hypertension
Smith, M. A.; Guardado, E. S.; Boehme, J.; Datar, S. A.; Maltepe, E.; Swami, N.; Raff, G. W.; Bodansky, A.; Moreno, J.; Prince, A.; Powers, N.; Huang, G. N.; de Jesus Perez, V.; Fineman, J. R.
10.1101/2024.12.04.626551 — physiology — Posted on 2024-12-09
3772 Vasoinhibin is Generated by the Renin-Angiotensin System
Nunez, F. F.; Siqueiros-Marquez, L.; Adan-Castro, E.; Zamora, M.; Robles, J. P.; Ruiz-Herrera, X.; Bertsch, T.; Triebel, J.; Martinez de la Escalera, G.; Clapp, C.
10.1101/2024.12.04.626908 — physiology — Posted on 2024-12-09
3773 Degradation of LMO2 in T cell leukaemia causes collateral breakdown of transcription complex partners and LMO2-dependent apoptosis
Sereesongsaeng, N.; Bataille, C.; Russell, A.; Bery, N.; Sialana, F.; Choudhary, J.; Miller, A.; Rabbitts, T.
10.1101/2024.12.09.627495 — cancer biology — Posted on 2024-12-09
3777 Cell-type specific autophagy in human leukocytes
Dang, L.; Martin, A.; Carosi, J. M.; Gore, J.; Singh, S.; Sargeant, T. J.
10.1101/2024.12.08.627423 — cell biology — Posted on 2024-12-09
3778 Cell volume regulates terminal differentiation of cultured human epidermal keratinocytes
Watt, F. M.; Zijl, S.; Hiratsuka, T.; Mobasseri, A.; Ebrahimkutty, M.; Boermel, M.; Garcia-Manyes, S.
10.1101/2024.12.09.627463 — cell biology — Posted on 2024-12-09
3779 Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response
Lafranchi, L.; Spinner, A.; Hornisch, M.; Schlesinger, D.; Luzon, C. N.; Brinkenstrahle, L.; Shao, R.; Piazza, I.; Elsässer, S. J.
10.1101/2024.12.08.627409 — cell biology — Posted on 2024-12-09
3781 mTOR signaling governs the formation of epithelial apical projection via S6K1-RhoA and aPKC-Lgl2 axes
Sen, S.; Ghosh, P.; Mukherjee, S.; Khurana, G.; Pinto, C. S.; Gupta, K.; Venkatramani, R.; Sonawane, M.
10.1101/2024.12.08.627438 — cell biology — Posted on 2024-12-09
3782 Glomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy
Yoon, J.; Liu, Z.; Alaba, M.; Bruggeman, L. A.; Janmey, P.; Arana, C.; Ayenuyo, O.; Medeiros, I.; Eddy, S.; Kretzler, M.; Henderson, J. M.; Nair, V.; Naik, A.; Chang, A. N.; Miller, R. T.
10.1101/2024.02.26.582201 — cell biology — Posted on 2024-12-09
3783 Making yogurt with the ant holobiont uncovers bacteria, acids, and enzymes for food fermentation
Sinotte, V. M.; Ramos Viana, V.; Vasquez, D. P.; Sirakova, S. M.; Valeron, N. R.; Cuesta Mate, A.; Taylor Parkins, S. K.; Giecko, J.; Velasco, E. M.; Zilber, D.; Munk, R.; Andersen, S. B.; Dunn, R. R.; Jahn, L. J.
10.1101/2024.09.16.613207 — microbiology — Posted on 2024-12-09
3784 Causality Mapping Using Resting-state fMRI Reveals Hyperactivity and Hypoconnectivity in Schizophrenia Patients
Tahir, A.; Abdullah, W.; Azeem, W. u.; Khalid, M. F.; Abualait, T.; Shakil, S.; Ahmed, F.; Bashir, S.; Chaudhary, S. U.
10.1101/2024.09.25.614909 — neuroscience — Posted on 2024-12-09
3786 Naturally ornate RNA-only complexes revealed by cryo-EM
Kretsch, R. C.; Wu, Y.; Shabalina, S. A.; Lee, H.; Nye, G. P.; Koonin, E. V.; Gao, A.; Chiu, W.; Das, R.
10.1101/2024.12.08.627333 — biophysics — Posted on 2024-12-09
3790 Pseudomonas taxonomic and functional microdiversity in the wheat rhizosphere is cultivar-dependent and links to disease resistance profile and root diameter
Herms, C. H.; Hennessy, R. C.; Bak, F.; Guan, Y.; Browne, P. D.; Nielsen, T. K.; Hansen, L. H.; Dresboll, D. B.; Nicolaisen, M.
10.1101/2024.06.13.598955 — microbiology — Posted on 2024-12-09
3791 Parkinson's disease-associated Pink1 loss disrupts vesicle trafficking in ensheathing glia causing dopaminergic neuron synapse loss
Ghezzi, L.; Pech, U.; Schoovaerts, N.; Poovathingal, S.; Davie, K.; Lamote, j.; Praschberger, R.; Verstreken, P.
10.1101/2024.12.06.627235 — neuroscience — Posted on 2024-12-09
3793 Beyond dichotomy: diversity of rat's ultrasonic vocalizations
Wada, R.; Hakataya, S.; Tachibana, R. O.; Shiramatsu, T. I.; Ito, T.; Kanno, K.; Koshiishi, R.; Matsumoto, J.; Saito, Y.; Toya, G.; Okabe, S.; Okanoya, K.
10.1101/2024.12.09.627446 — animal behavior and cognition — Posted on 2024-12-09
3794 Cis-Regulatory Evolution of CCNB1IP1 Driving Gradual Increase of Cortical Size and Folding in primates
Hu, T.; Kong, Y.; Tan, Y.; Ma, P.; Wang, J.; Sun, X.-L.; Xiang, K.; Mao, B.; Wu, Q.-F.; Yi, S.; SHI, L.
10.1101/2024.12.08.627376 — evolutionary biology — Posted on 2024-12-09
3795 Partitioning the genomic journey to becoming Homo sapiens
Pagani, L.; Bertazzon, R.; Panratov, V.; Vallini, L.; Marnetto, D.; Esposito, M.; Granata, I.; Teo, E. E.; Loganathan, A. L.; Hallast, P.; Lee, C.; Ayub, Q.; Mezzavilla, M.
10.1101/2024.12.09.627480 — evolutionary biology — Posted on 2024-12-09
3798 A murine model of cardiovascular-kidney-metabolic syndrome demonstrates compromised limb function in the ischemic hind limb
Chitalia, V.; Lotfollahzadeh, S.; Paul, H.; Bonefascio, J.; Almiron, R.; Hockestra, I.; Prezkop, K.; Yamamoto, T.; Piqueras, M. C.; Yin, W.; Malikova, M.; Siracuse, J. J.; Belghasem, M.; Cabral, H.; Sayed, N.
10.1101/2024.12.03.626707 — pathology — Posted on 2024-12-09
3799 Aspergillus latus: a cryptic causative agent of aspergillosis emerging in Japan
Shibata, S.; Uchida, M.; Ban, S.; Kamei, K.; Watanabe, A.; Yaguchi, T.; Hubka, V.; Takahashi, H.
10.1101/2024.11.25.625089 — microbiology — Posted on 2024-12-09
3800 A heterogeneous population code at the first synapse of vision
Herzog, T.; Yoshimatsu, T.; Moya-Diaz, J.; James, B.; Lagnado, L.; Baden, T.
10.1101/2024.05.03.592379 — neuroscience — Posted on 2024-12-09
3801 Using normative models pre-trained on cross-sectional data to evaluate intra-individual longitudinal changes in neuroimaging data
Rehak Buckova, B.; Fraza, C.; Rehak, R.; Kolenic, M.; Beckmann, C.; Spaniel, F.; Marquand, A.; Hlinka, J.
10.1101/2023.06.09.544217 — neuroscience — Posted on 2024-12-09
3803 Sampling Conformational Ensembles of Highly Dynamic Proteins via Generative Deep Learning
Ruzmetov, T.; Hung, T. I.; Jonnalagedda, S. P.; Chen, S.-h.; Fasihianifard, P.; Guo, Z.; Bhanu, B.; Chang, C.-e. A.
10.1101/2024.05.05.592587 — biophysics — Posted on 2024-12-09
3804 Cell Membranes Sustain Phospholipid Imbalance Via Cholesterol Asymmetry
Doktorova, M.; Symons, J. L.; Zhang, X.; Wang, H.-Y.; Schlegel, J.; Lorent, J. H.; Heberle, F. A.; Sezgin, E.; Lyman, E.; Levental, K. R.; Levental, I.
10.1101/2023.07.30.551157 — biophysics — Posted on 2024-12-09
3806 Scorpio : Enhancing Embeddings to Improve Downstream Analysis of DNA sequences
Refahi, M.; Sokhansanj, B. A.; Mell, J. C.; Brown, J.; Yoo, H.; Hearne, G.; Rosen, G.
10.1101/2024.07.19.604359 — genomics — Posted on 2024-12-09
3808 Oviductin sets the species-specificity of the mammalian zona pellucida
de la Fuente, D.; Maroto, M.; Cajas, Y. N.; Canon-Beltran, K.; Fernandez-Gonzalez, R.; Munoz-Maceda, A.; Sanchez-Puig, J. M.; Blasco, R.; Cots, P.; Aviles, M.; Rizos, D.; Gutierrez-Adan, A.
10.1101/2024.07.01.601502 — developmental biology — Posted on 2024-12-09
3815 Biological Database Mining for LLM-Driven Alzheimer's Disease Drug Repurposing
Schmitt, R. A.; Buelau, K.; Martin, L.; Huettl, C. V. M.; Schirner, M.; Stefanovski, L.; Ritter, P.
10.1101/2024.12.04.626255 — neuroscience — Posted on 2024-12-08
3816 CASSIA allows for robust, automated cell annotation in single-cell RNA-sequencing data
Xie, E.; Cheng, L.; Shireman, J.; Cai, Y.; Liu, J.; Mohanty, C.; Dey, M.; Kendziorski, C.
10.1101/2024.12.04.626476 — bioinformatics — Posted on 2024-12-08
3818 SpatioMark: Quantifying the impact of spatial proximity on cell phenotype
Iyengar, S. S.; Qin, A. R.; Robertson, N.; Harman, A. N.; Patrick, E.
10.1101/2024.12.04.626887 — bioinformatics — Posted on 2024-12-08
3819 The discovery of 5mC-selective deaminases and their application to ultra-sensitive direct sequencing of methylated sites at base resolution.
Yang, W.; Lee, Y.-J.; Silva, R. M. B.; DeLiberto, A.; Yancey, C.; McCallum, D.; Buss, J.; Moncion, R.; Ong, J.; Mabuchi, M.; Hough, D.; Weigele, P. R.; Ettwiller, L. M.
10.1101/2024.12.05.627091 — genomics — Posted on 2024-12-08
3820 Meiotic Sex Chromosome Inactivation: conservation across the Drosophila genus
Avelino, C. C.; Mendonca, C. A.; Goldstein, G.; Carvalho, A. B.; Vibranovski, M. D.
10.1101/2024.12.04.626848 — genetics — Posted on 2024-12-08
3824 Hyaluronic Acid and Emergent Tissue Mechanics Orchestrate Digit Tip Regeneration
Mui, B. W. H.; Wong, J. Y.; Bray, T.; Connolly, L.; Wang, J. H.; Winkel, A.; Robey, P. G.; Franze, K.; Chalut, K. J.; Storer, M. A.
10.1101/2024.12.04.626830 — developmental biology — Posted on 2024-12-08
3827 Glucose-Sensing ChREBP Protein in the Pathogenesis of Diabetic Retinopathy
Starr, C. R.; Zhylkibayev, A.; Gorbatyuk, O.; Nuotio-Antar, A. M.; Mobley, J.; Grant, M. B.; Gorbatyuk, M.
10.1101/2024.12.04.626828 — cell biology — Posted on 2024-12-08
3828 One-Size-Fits-Many: Antisense oligonucleotides for rescuing splicing mutations in hotspot exons
Duan, C.; Rong, S.; Buerer, L.; Neil, C. R.; Savatt, J. M.; Strande, N. T.; Fairbrother, W. G.
10.1101/2024.12.07.627366 — molecular biology — Posted on 2024-12-08
3829 Human iPSCs-derived muscle cells as a new model for investigation of EDMD1 pathogenesis.
Lisowska, M.; Rowinska, M.; Suszynska, A.; Bearzi, C.; Łaczmanska, I.; Hanusek, J.; Kunik, A.; Dzianisava, V.; Rzepecki, R.; Machowska, M.; Piekarowicz, K.
10.1101/2024.12.08.627381 — molecular biology — Posted on 2024-12-08
3830 The activity of soil microbial taxa in the rhizosphere predicts the success of root colonization
Harris, J. E.; Bledsoe, R. B.; Guha, S.; Omari, H.; Crandall, S. G.; Burghardt, L. T.; Couradeau, E. M.
10.1101/2024.12.07.627353 — microbiology — Posted on 2024-12-08
3832 Regulation of B cell migration to the Bursa of Fabricius by CCR7 and cell adhesion molecules in chicken embryonic development
Brunner, M.; Cavaleiro, C. L. C. T.; Berghof, T. V. L.; Wurmser, C.; Elleder, D.; von Heyl, T.; Schusser, B.
10.1101/2024.12.04.626876 — immunology — Posted on 2024-12-08
3836 Lipid-based nanoparticles deliver mRNA to reverse the pathogenesis of lysosomal acid lipase deficiency in a preclinical model
Zadory, M.; Lopez-Vince, E.; Haddouch, H.; Babity, S.; Rezaei, N.; Moawad, F.; Kenaan El Rahbani, R. M.; Vujic, N.; Kratky, D.; Gravel, S.-P.; Brambilla, D.
10.1101/2024.12.07.627318 — bioengineering — Posted on 2024-12-08
3839 Structural basis for aminoacylation of cellular modified tRNALys3 by human lysyl-tRNA synthetase
Devarkar, S. C.; Budding, C. R.; Pathirage, C.; Kavoor, A.; Herbert, C.; Limbach, P. A.; Musier-Forsyth, K.; Xiong, Y.
10.1101/2024.12.07.627298 — biochemistry — Posted on 2024-12-08
3842 Human genetic variation reveals FCRL3 is a lymphocyte receptor for Yersinia pestis
Keener, R.; Shi, S.; Dalapati, T.; Wang, L.; Reinoso-Vizcaino, N. M.; Luftig, M. A.; Miller, S. I.; Wilson, T. J.; Ko, D. C.
10.1101/2024.12.05.626452 — genetics — Posted on 2024-12-08
3844 Degron-modified Cas12a enhances single-cell CRISPR screening
Snetkova, V.; Galan, C.; Lopez, R.; Rios, A. R.; Kudo, T.; Dorighi, K.; Warming, S.; Haley, B. J.
10.1101/2024.12.08.627374 — molecular biology — Posted on 2024-12-08
3845 Elevated levels of intracellular RNA lariats suppress the antiviral response
Duan, C.; Buerer, L.; Bowers, C.; Taggart, A. J.; OBrien, M. H.; Gunasekera, S.; Lin, C.-L.; Wang, J.; Staley, J. P.; Fredericks, A. M.; Monaghan, S. F.; Welch, A.; Clark, N. E.; Gao, D.; Marr, N.; Zhang, S.-Y.; Casanova, J.-L.; Fairbrother, W. G.
10.1101/2024.12.07.627371 — molecular biology — Posted on 2024-12-08
3847 RNA binding protein IMP1/ZBP1 drives Actb mRNA localization and local translation in microglial peripheral processes and mediates morphological changes, motility and phagocytosis in response to inflammation
Imaz-Iruretagoyena, J.; Blanco-Urrejola, M.; Nunez-Garcia, I.; Garcia-Toledo, I.; Garcia-Beltran, L. C.; Marquez, M.; Corrochano, S.; Sierra, A.; Baleriola, J.
10.1101/2023.07.31.551329 — neuroscience — Posted on 2024-12-08
3848 Diel changes in the expression of a marker gene and candidate genes for intracellular amorphous CaCO3 biomineralization in Microcystis
Bruley, A.; Gaëtan, J.; Gugger, M.; Pancrace, C.; Millet, M.; Gaschignard, G.; Dezi, M.; Humbert, J.-F.; Leloup, J.; Skouri-Panet, F.; Callebaut, I.; Benzerara, K.; Duprat, E.
10.1101/2024.07.07.602159 — microbiology — Posted on 2024-12-08
3849 Trade-off between sample volume passaged and number of passages involved during serial dilution for bacterial enumeration
Jain, M.; Begum, S.; Bhuyan, S.; Nath, C.; Kashyap, U.; Dutta, L.; Giri, S. J.; Deka, N.; Mandal, M.; Kumar, A.; Ray, S. K.
10.1101/2024.11.28.625891 — microbiology — Posted on 2024-12-08
3850 Distinct genetic underpinnings of inter-individual differences in the sensorimotor-association axis of cortical organisation
Bignardi, G.; Nivard, M. G.; Schaare, H. L.; Bernhardt, B. C.; Bethlehem, R. A. I.; Fisher, S. E.; Valk, S. L.
10.1101/2023.07.13.548817 — neuroscience — Posted on 2024-12-08
3856 FAK activity exacerbates disturbed flow-mediated atherosclerosis via VEGFR2-Cbl-NF-κB signaling.
Lim, S.; Murphy, J. M.; Tran, D.; Jeong, K.; Nguyen, L. T.; Nguyen, M.; Tambe, D. T.; Jo, H.; Ahn, E.-Y. E.
10.1101/2024.12.06.627217 — cell biology — Posted on 2024-12-08
3860 SubCell: Vision foundation models for microscopycapture single-cell biology
Gupta, A.; Wefers, Z.; Kahnert, K.; Hansen, J. N.; Leineweber, W. D.; Cesnik, A.; Lu, D.; Axelsson, U.; Ballllosera Navarro, F.; Karaletsos, T.; Lundberg, E.
10.1101/2024.12.06.627299 — cell biology — Posted on 2024-12-08
3861 MuSpAn: A Toolbox for Multiscale Spatial Analysis
Bull, J. A.; Moore, J. W.; Mulholland, E. J.; Leedham, S. J.; Byrne, H. M.
10.1101/2024.12.06.627195 — cell biology — Posted on 2024-12-08
3863 Store-operated Ca2+ entry is involved in endothelium-to-mesenchymal transition in lung vascular endothelial cells
Babicheva, A.; Elmadbouh, I.; Song, S.; Thompson, M. A.; Powers, R.; Jain, P. P.; Izadi, A.; Chen, J.; Yung, L.; Parmisano, S.; Paquin, C.; Wang, W.-T.; Chen, Y.; Wang, T.; Alotaibi, M.; Shyy, J. Y.- J.; Thistlethwaite, P. A.; Wang, J.; Makino, A.; Prakash, Y. S.; Pabelick, C. M.; Yuan, J.
10.1101/2024.12.06.627034 — cell biology — Posted on 2024-12-08
3864 Characterization of the Glutathione Redox State in the Golgi Apparatus
Miro-Vinyals, C.; Emmert, S.; Grammbitter, G.; Jud, A.; Kockmann, T.; Rivera-Fuentes, P.
10.1101/2024.12.06.627163 — cell biology — Posted on 2024-12-08
3869 Whole Virion Proteomics of HCMV Reveals that gpUL141 is a Virion Component that Regulates Envelope Glycoprotein Composition to Protect Against Humoral Immunity
Bentley, K.; Statkute, E.; Murrell, I.; Fielding, C.; Antrobus, R.; Preston, H.; Kerr, L.; Cochrane, D.; Brizic, I.; Lehner, P. J.; Wilkinson, G. W.; Wang, E. C. Y.; Graham, S. C.; Weekes, M. P.; Stanton, R. J.
10.1101/2024.11.29.626001 — microbiology — Posted on 2024-12-08
3870 Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology
Lipp, I.; Kirilina, E.; Jaeger, C.; Morawski, M.; Jauch, A.; Pine, K. J.; Edwards, L. J.; Helbling, S.; Rose, D.; Helms, G.; Eichner, C.; Deschner, T.; Graessle, T.; EBC consortium, ; Gunz, P.; Anwander, A.; Friederici, A. D.; Wittig, R. M.; Crockford, C.; Weiskopf, N.
10.1101/2024.12.06.627145 — neuroscience — Posted on 2024-12-08
3871 HCN1 channels in GABAergic amygdalar neurons underpin male-biased aggressive behaviors
Li, K.; Zhu, Z.; Wang, Q.; Pan, L.; Miao, L.; Deng, G.; Wu, J.; Lou, H.; Zeng, L.; Liu, Y.; Li, X.-M.; Duan, S.; Sun, L.; Yu, Y.
10.1101/2024.12.07.627305 — neuroscience — Posted on 2024-12-08
3875 Dads on duty: First account of nest sitting in barnacle ganders
Scheiber, I. B. R.; Slettenhaar, A. J.; Loonen, M. J. J. E.; de Jong, M. E.
10.1101/2024.07.19.604238 — animal behavior and cognition — Posted on 2024-12-08
3877 BindCraft: one-shot design of functional protein binders
Pacesa, M.; Nickel, L.; Schellhaas, C.; Schmidt, J.; Pyatova, E.; Kissling, L.; Barendse, P.; Choudhury, J.; Kapoor, S.; Alcaraz-Serna, A.; Cho, Y.; Ghamary, K. H.; Vinue, L.; Yachnin, B. J.; Wollacott, A. M.; Buckley, S.; Westphal, A. H.; Lindhoud, S.; Georgeon, S.; Goverde, C. A.; Hatzopoulos, G. N.; Gonczy, P.; Muller, Y. D.; Schwank, G.; Swarts, D. C.; Vecchio, A. J.; Schneider, B. L.; Ovchinnikov, S.; Correia, B. E.
10.1101/2024.09.30.615802 — bioinformatics — Posted on 2024-12-07
3880 Mechanistic basis of lineage restriction
Wu, B.; Lee, J. H.; Foshay, K. M.; Zhang, L.; Fernandes, C. J.; Gao, B.; Dou, X.; Zhang, C. Z.; Fan, G.; Xiao, B. X.; Lahn, B. T.
10.1101/2024.08.07.606262 — developmental biology — Posted on 2024-12-08
3885 Amyloid Beta Precursor Protein contributes to brain aging and learning decline in short-lived turquoise killifish (Nothobranchius furzeri)
de Bakker, D. E. M.; Mihaljevic, M.; Gharat, K.; Richter, J.; Bagnoli, S.; van Bebber, F.; Adam, L.; Shamim-Schulze, F.; Ohlenschlaeger, O.; Bens, M.; Cirri, E.; Antebi, A.; Matic, I.; Schneider, A.; Schmid, B.; Cellerino, A.; Kirstein, J.; Valenzano, D. R.
10.1101/2024.10.11.617841 — neuroscience — Posted on 2024-12-08
3886 High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissue
Haines, M.; Thorup, J. R.; Gohsman, S.; Ctortecka, C.; Newton, C.; Rohrer, D. C.; Hostetter, G.; Mani, D. R.; Gillette, M. A.; Satpathy, S.; Carr, S. A.
10.1101/2024.11.17.624038 — systems biology — Posted on 2024-12-07
3887 Synthetic ratio computation for programming population composition and multicellular morphology
An, B.; Tang, T.-C.; Zhang, Q.; Wang, T.; Gan, K.; Liu, K.; Liu, Y.; Wang, Y.; Shaw, W. M.; Liang, Q.; Wang, Y.; Lu, T. K.; Church, G. M.; Zhong, C.
10.1101/2024.11.26.624747 — synthetic biology — Posted on 2024-12-07
3888 Exploration of the genetic landscape of bacterial dsDNA viruses reveals an ANI gap amidst extensive mosaicism
Ndovie, W.; Havranek, J.; Leconte, J.; Koszucki, J.; Chindelevitch, L.; Adriaenssens, E. M.; Mostowy, R. J.
10.1101/2024.04.23.590796 — bioinformatics — Posted on 2024-12-07
3889 Adult honey bee queens consume pollen and nectar
St. Clair, A.; Dwyer, B.; Shapiro, M.; Dolezal, A. G.
10.1101/2024.12.04.626851 — ecology — Posted on 2024-12-07
3890 Epigenetic silencing and blockade of latency reversal by an HIV-1 encoded antisense transcript
Li, R.; Daneshvar, K.; Ji, X.; Pleet, M.; Igbinosun, G.; Iqbal, M. S.; Kashanchi, F.; Mullen, A.; Romerio, F.
10.1101/2024.12.06.627241 — molecular biology — Posted on 2024-12-07
3892 Pathogens and Antimicrobial Resistance Genes in Household Environments: A Study of Soil Floors and Cow Dung in Rural Bangladesh
Nguyen, A. T.; Ratnasiri, K.; Barratt Heitmann, G.; Tazin, S.; Anderson, C. E.; Hanif, S.; Yeamin, A.; Shoab, A. K.; Shanta, I. S.; Jahan, F.; Hossain, M. S.; Mahmud, Z. H.; Jubair, M.; Rahman, M.; Rahman, M.; Ercumen, A.; Benjamin-Chung, J.
10.1101/2024.12.06.627269 — microbiology — Posted on 2024-12-07
3893 MCSPACE: inferring microbiome spatiotemporal dynamics from high-throughput co-localization data
Uppal, G.; Urtecho, G. K.; Richardson, M.; Comba, I. Y.; Lee, J.; Moody, T.; Wang, H. H.; Gerber, G. K.
10.1101/2024.12.06.627244 — microbiology — Posted on 2024-12-07
3895 The evolution of pectate lyase-like genes across land plants, and their roles in haustorium formation in parasitic plants
Zhang, H.; Wafula, E. K.; Kelly, E. M.; Ko, I.; Yocca, A.; Bandaranayake, P. C. G.; Yang, Z.; Yoder, J.; Honaas, L.; dePamphilis, C.
10.1101/2024.12.04.626843 — plant biology — Posted on 2024-12-07
3896 Zymoseptoria tritici stealth infection is facilitated by stage-specific down-regulation of a β-glucanase
Rebaque, D.; Carrasco-Lopez, C.; Krishnan, P.; Lopez, G.; Lopez-Cobos, S.; de Salas, F.; Meile, L.; Lorrain, C.; Largo-Gosens, A.; McDonald, B. A.; Vilaplana, F.; Martinez, M. J.; Melida, H.; Molina, A. A.; Sanchez-Vallet, A.
10.1101/2024.12.04.626787 — plant biology — Posted on 2024-12-07
3898 Epigenetic remodeling and 3D chromatin reorganization governed by NKX2-1 drive neuroendocrine prostate cancer
Lu, X.; Keo, V.; Cheng, I.; Xie, W.; Gritsina, G.; Wang, J.; Jin, Q.; Jin, P.; Yue, F.; Sanda, M. G.; Corces, V.; Altemose, N.; Zhao, J. C.; Yu, J.
10.1101/2024.12.04.626816 — cancer biology — Posted on 2024-12-07
3900 Potent antitumor activity of a designed interleukin-21 mimic
Chun, J.-H.; Lim, B. S.; Roy, S.; Walsh, M. J.; Abhiraman, G. C.; Zhangxu, K.; Atajanova, T.; Revach, O.-Y.; Clark, E. C.; Li, P.; Palin, C. A.; Khanna, A.; Tower, S.; Kureshi, R.; Hoffman, M. T.; Sharova, T.; Lawless, A.; Cohen, S.; Boland, G. M.; Nguyen, T.; Peprah, F.; Tello, J. G.; Liu, S. Y.; Kim, C. J.; Shin, H.; Quijano-Rubio, A.; Jude, K. M.; Ulge, U. Y.; Gerben, S.; Murray, A.; Heine, P.; DeWitt, M.; Carter, L.; King, N. P.; Silva, D.-A.; Kueh, H. Y.; Kalia, V.; Sarkar, S.; Jenkins, R. W.; Garcia, K. C.; Leonard, W. J.; Dougan, M.; Dougan, S. K.; Baker, D.
10.1101/2024.12.06.626481 — biochemistry — Posted on 2024-12-07
3903 Interparental Gene Conversion in General Population: A Novel Mechanism For Loss of Heterozygosity
Toratani, J.; Tachibana, M.; Sugawara, J.; Sugawara, A.; Sato, T.; Takahashi, Y.; Hiraga, H.; Yokoyama, E.; Watanabe, Z.; Saito, M.; Yaegashi, N.; Tamiya, G.; Takayama, J.
10.1101/2024.12.05.626979 — genomics — Posted on 2024-12-07
3908 Fertilization impacts microbiomes along the grassland trophic chain
Jetter, K.; Jani, K.; Wilhelm, K.; Stehle, U.; Chamedjeu, R.; Riedel, C.; Wilfert, L.; Schaefer, P.; Sommer, S.
10.1101/2024.12.06.627205 — microbiology — Posted on 2024-12-07
3909 A CRISPRi Library Screen in Group B Streptococcus Identifies Surface Immunogenic Protein (Sip) as a Mediator of Multiple Host Interactions
Firestone, K.; Gopalakrishna, K. P.; Rogers, L. M.; Peters, A.; Gaddy, J.; Nichols, C.; Hall, M. H.; Varela, H. N.; Carlin, S. M.; Hillebrand, G. H.; Giacobe, E. J.; Aronoff, D. M.; Hooven, T. A.
10.1101/2024.12.06.627252 — microbiology — Posted on 2024-12-07
3911 Interaction of plant-derived metabolites and rhizobiome functions enhances drought stress tolerance
Kazarina, A.; Sarkar, S.; Adams, B.; Rodela, L.; Pogranichny, S.; Hartung, E.; Johnson, L.; Jumpponen, A. M.; Lee, S. T. M.
10.1101/2024.12.06.627064 — microbiology — Posted on 2024-12-07
3913 The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir
Huang, S.-W.; Briganti, L.; Annamalai, A. S.; Greenwood, J.; Shkriabai, N.; Haney, R.; Armstrong, M. L.; Wempe, M. F.; Singh, S. P.; Francis, A. C.; Engelman, A. N.; Kvaratskhelia, M.
10.1101/2024.12.06.627250 — microbiology — Posted on 2024-12-07
3914 A neural circuit for context-dependent multimodal signaling in Drosophila
Steinfath, E.; Khalili, A.; Stenger, M.; Schultze, B. L.; Ravindran, S. N.; Alizadeh, K.; Clemens, J.
10.1101/2024.12.04.625245 — neuroscience — Posted on 2024-12-07
3916 MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics
Martin, N. X.; Olsen, P.; Quon, J.; Campos, J.; Valera Cuevas, N. J.; Nagra, J.; VanNess, M.; Maltzer, Z.; Gelfand, E.; Oyama, A.; Gary, A.; Wang, Y.; Alaya, A.; Ruiz, A.; Reynoldson, C.; Bielstein, C.; Pom, C. A.; Huang, C.; Slaughterback, C.; Liang, E.; Alexander, J.; Ariza, J.; Malone, J.; Melchor, J.; Colbert, K.; Brouner, K.; Shulga, L.; Reding, M.; Latimer, P.; Sanchez, R.; Barta, S.; Egdorf, T.; Madigan, Z.; Pagan, C.; Close, J.; Long, B.; Kunst, M.; Lein, E.; Zeng, H.; McMillen, D. A.; Waters, J.
10.1101/2024.12.04.626766 — bioinformatics — Posted on 2024-12-07
3917 Integration of diverse bioactivity data into the Chemical Checker compound universe
Comajuncosa-Creus, A.; Bertoni, M.; Duran-Frigola, M.; Fernandez-Torras, A.; Guitart-Pla, O.; Kurzawa, N.; Locatelli, M.; Martins, Y.; Pareja-Lorente, E.; Rojans-Granado, G.; Soler, N.; Viesi, E.; Aloy, P.
10.1101/2024.12.04.626832 — bioinformatics — Posted on 2024-12-07
3919 Disruption of basal CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms
Mobach, S.; Bergkamp, N. D.; Ma, Z.; Haselager, M. V.; Anbuhl, S. M.; Jurriens, D.; van den Bor, J.; Wang, Z.; Crudden, C. J.; Roos, J. L.; Perez Almeria, C. V.; Boergonje, R.; Lohse, M. J.; Bosma, R.; Eldering, E.; Siderius, M.; Wu, W.; Spaargaren, M.; Tonino, S. H.; Kater, A. P.; Smit, M. J.; Heukers, R.
10.1101/2024.12.06.627249 — biochemistry — Posted on 2024-12-07
3920 Synergistic generation of cardiac resident-like macrophages and cardiomyocyte maturation in tissue engineered platforms
Suku, M.; Murphy, J. F.; Corbezzolo, S.; Biggs, M.; Forte, G.; Turnbull, I. C.; Costa, K. D.; Forrester, L.; Monaghan, M. G.
10.1101/2024.12.04.626684 — bioengineering — Posted on 2024-12-07
3922 TRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner
Madlmayr, A.; Hoelting, K.; Hoeger, B.; Lewitz, D.; Weng, M.; Haider, T.; Duggan, M.; Ross, R.; Horgen, F. D.; Sperandio, M.; Dietrich, A.; Gudermann, T.; Zierler, S.
10.1101/2024.12.04.626765 — immunology — Posted on 2024-12-07
3923 A Reference Tissue Implementation of Simultaneous Multifactor Bayesian Analysis (SiMBA) of PET Time Activity Curve Data
Matheson, G. J.; Lundberg, J.; Garde, M.; Veldman, E. R.; Tateno, A.; Okubo, Y.; Tiger, M.; Ogden, R. T.
10.1101/2024.12.04.626559 — neuroscience — Posted on 2024-12-07
3924 Spike sorting biases and information loss in a detailed cortical model
Laquitaine, S.; Imbeni, M.; Tharayil, J.; Isbister, J. B.; Reimann, M. W.
10.1101/2024.12.04.626805 — neuroscience — Posted on 2024-12-07
3926 SUMO Inhibition Plus CD40 Agonism Increases Anti-Tumor Immunogenicity Through Interferon Mediated Macrophage Activation
Li, K. Y.; Courelli, A.; Lee, H. J.; De Mendoza, T. H.; Martsinkovskiy, A.; Mose, E.; Patel, J.; Ng, I.; Sun, S.; Tharuka, M. D. N.; Tiriac, H.; Chen, Y.; Lowy, A. M.
10.1101/2024.12.03.626688 — cancer biology — Posted on 2024-12-07
3927 Mapping of Multilineage Tumor Cell Populations in Mouse Bladder Cancer
Schrode, N.; Hu, Y.; Yu, H.; Galsky, M.; Sfakianous, J.; Sebra, R.; Beaumont, K. G.; Mulholland, D. J.
10.1101/2024.12.04.626806 — cancer biology — Posted on 2024-12-07
3928 In vitro neuroendocrine differentiation of BPH-1 cells under beta2 adrenergic receptor stimulation
PIGAT, N.; GARRIDO CASTILLO, L. N.; LEFREVE, C.; BAURES, M.; Goffin, V.; ANRACT, J.; ARMAND, A.-S.; Capiod, T.
10.1101/2024.12.04.626774 — cancer biology — Posted on 2024-12-07
3931 Prediction of peptide structural conformations with AlphaFold2
Ille, A. M.; Markosian, C.; Burley, S. K.; Pasqualini, R.; Arap, W.
10.1101/2024.12.03.626727 — bioinformatics — Posted on 2024-12-07
3932 Whole mitochondrial genome analysis of Aedes aegypti reveal association with Wolbachia infection
Gupta, B.; Sumitha, M. K.; Pandiyan, G. N.; Kalimuthu, M.; Paramasivan, R.; Rahi, M.
10.1101/2024.12.04.626768 — genomics — Posted on 2024-12-07
3934 A feline model of human LDLR-related atherosclerosis
Hytonen, M. K.; Karkamo, V.; Hundi, S.; Airas, N.; Kaukonen, M.; Sukura, A.; Lyons, L. A.; Anderson, H. A.; Kareinen, I.; Lohi, H.
10.1101/2024.12.04.626782 — genetics — Posted on 2024-12-07
3941 Estimating survival of an anadromous salmonid using Bayesian hierarchical models applied to acoustic telemetry, biological, and environmental data
Munaweera, I.; Harris, L. N.; Moore, J.-S.; Tallman, R. F.; Gilbert, M.; Fisk, A. T.; Else, B. G. T.; Ahmed, M. M. M.; Gillis, D. M.; Muthukumarana, S.
10.1101/2024.12.04.626433 — ecology — Posted on 2024-12-07
3946 Cortical dynamics underlying initiation of rapid steps with contrasting postural demands
Giesbers, I.; Billen, L. S.; van der Cruijsen, J.; Corneil, B. D.; Weerdesteyn, V.
10.1101/2024.12.04.626758 — neuroscience — Posted on 2024-12-07
3948 Spermidine alleviates depression via control of the stress response
Mackert, S.; Niemeyer, C.; Mecdad, Y.; Ebert, T.; Bajaj, T.; Durand, S.; Hofer, S. J.; Zellner, A.; Besteher, B.; Engelmann, J.; Gisabella, B.; Kempf, V.; Heckmann, L. A.; Laakmann, M.; Newman, E. L.; Sokn, C.; Heinz, D. E.; Junglas, E.; Uribe-Marino, A.; Magnes, C.; Klengel, C.; Mueller, A.; Opriessnig, L.; Meinitzer, A.; Lennarz, M.; Martin, K. M. W.; Albatarni, R.; Brockherde, M.; Lieb, K.; Rohner, H.; Stoffel-Wagner, B.; Philipsen, A.; Kuster, B.; Koelle, M.; Ressler, K. J.; Opel, N.; Schmidt, M. V.; Pantazopoulos, H.; Mueller, M. B.; Kroemer, G.; Eisenberg, T.; Hartmann, J.; Madeo, F.; Ga
10.1101/2024.12.04.626625 — neuroscience — Posted on 2024-12-07
3949 Structural regeneration and functional recovery of the olfactory system of zebrafish following brain injury
Calvo-Ochoa, E.; Vorhees, N. W.; Lockett, T. P.; DeWitt, S. L.; Thomas, E. A.; Gray, A. B.; Miyasaka, N.; Yoshihara, Y.; Byrd-Jacobs, C. A.
10.1101/2024.12.03.626704 — neuroscience — Posted on 2024-12-07
3951 At-RS31 orchestrates hierarchical cross-regulation of splicing factors and integrates alternative splicing with TOR-ABA pathways
Koster, T.; Venhuizen, P.; Lewinski, M.; Petrillo, E.; Marquez, Y.; Fuchs, A.; Ray, D.; Nimeth, B. A.; Riegler, S.; Franzmeier, S.; Zhong, H.; Hudges, T.; Morris, Q.; Barta, A.; Staiger, D.; Kalyna, M.
10.1101/2024.12.04.626797 — plant biology — Posted on 2024-12-07
3952 Lymphatic activation of ACKR3 signaling regulates lymphatic response after ischemic heart injury.
Balint, L.; Patel, S.; Serafin, D. S.; Zhang, H.; Quinn, K. E.; Aghajanian, A.; Kistner, B. M.; Caron, K. M.
10.1101/2024.12.04.626683 — physiology — Posted on 2024-12-07
3953 Adrenocortical Cancer Cell uptake of Iron Oxide Nanoparticles
Challapalli, R. S.; Hong, C.; Sorushanova, A.; Covarrubias-Zambrano, O.; Mullen, N.; Feely, S.; Covarrubias, J.; Varghese, S. N.; Hantel, C.; Owens, P.; OHalloran, M.; Prakash, P.; Bossmann, S. H.; Dennedy, M. C.
10.1101/2024.12.04.626790 — pharmacology and toxicology — Posted on 2024-12-07
3956 The gold complex auranofin sensitizes platinum resistant epithelial ovarian cancer cells to cisplatin
Abdalbari, F. H.; Forgie, B. N.; Zorychta, E. H.; Goyeneche, A. A.; Noman, A. S. M.; Telleria, C. M.
10.1101/2024.12.03.626677 — pathology — Posted on 2024-12-07
3960 RIDDEN: Data-driven inference of receptor activity from transcriptomic data
Barsi, S.; Varga, E.; Dimitrov, D.; Saez-Rodriguez, J.; Hunyady, L.; Szalai, B.
10.1101/2024.12.03.626558 — bioinformatics — Posted on 2024-12-07
3961 Comparative analysis of CRISPR/Cas9-targeted nanopore sequencing approaches in repeat expansion disorders
Benarroch, L.; Boelle, P.-Y.; Madry, H.; Mohand Oumoussa, B.; Eura, N.; Nishino, I.; Labreche, K.; Bassez, G.; Stojkovic, T.; Gourdon, G.; Bonne, G.; Tome, S.
10.1101/2024.12.04.626786 — bioinformatics — Posted on 2024-12-07
3962 Cell Type Differentiation Using Network Clustering Algorithms
Fatemi Nasrollahi, F. S.; Silva, F. N.; Liu, S.; Chaudhuri, S.; Yu, M.; Wang, J.; Nho, K.; Saykin, A. J.; Bennett, D. A.; Sporns, O.; Fortunato, S.
10.1101/2024.12.04.626793 — bioinformatics — Posted on 2024-12-07
3964 Drug Response Modeling across Cancers: Proteomics vs. Transcriptomics
Zheng, Z.; Huang, L.; Wang, F.; Liu, L.; Yu, J.; Xie, W.; Chen, X.; Li, X.; Wong, K.-C.
10.1101/2024.12.04.626700 — bioinformatics — Posted on 2024-12-07
3968 Engineered human lymph node stroma model for examining interstitial fluid flow and T cell egress
Hammel, J. H.; Arneja, A.; Cunningham, J.; Wang, M.; Schumaecker, S.; Orihuela, Y. M.; Ozulumba, T.; Zatorski, J.; Braciale, T. J.; Luckey, C. J.; Pompano, R. R.; Munson, J. M.
10.1101/2024.12.03.622729 — bioengineering — Posted on 2024-12-07
3969 Purifying circular RNA by ultrafiltration
Cuevas, K. d. J. G.; Lu, X.; Birtwistle, M. R.; Husson, S. M.
10.1101/2024.12.04.626383 — bioengineering — Posted on 2024-12-07
3970 High KIR diversity in Uganda and Botswana children living with HIV
John, M.; Kyobe, S.; Amujal, M.; Katagirya, E.; Diphoko, T.; Sebetso, G.; Mwesigwa, S.; Mboowa, G.; Retshabile, G.; Williams, L.; Mogomotsi, M.; Mlotshwa, B.; Jjingo, D.; kateete, D. P.; Joloba, M.; Mardon, G.; Hanchard, N.; Hollenbach, J. A.
10.1101/2024.12.03.626612 — genomics — Posted on 2024-12-07
3972 Two distinct structural variants involving EDN3 cause hyperpigmentation in chicken
Ma, C.; Huang, X.-H.; Wang, F.-J.; Zhang, S.-R.; Shi, X.; Weng, Z.-X.; Du, B.; Zhang, Y.-p.; Andersson, L.; Peng, M.-S.
10.1101/2024.12.04.626589 — genomics — Posted on 2024-12-07
3973 ERGA-BGE Reference Genome of the Striped Field Mouse (Apodemus agrarius), a Widespread and Abundant Species in Central and Eastern Europe
Janzekovic, F.; Buzan, E.; Boncina, A.; Escudero, N.; Fernandez, R.; Böhne, A.; Monteiro, R.; Aguilera, L.; Gut, M.; Camara Ferreira, F.; Cruz, F.; Gomez-Garrido, J.; Alioto, T. S.; Haggerty, L.; Martin, F.; De Panis, D.
10.1101/2024.12.04.626796 — genomics — Posted on 2024-12-07
3978 Identification of an Outbreak of Bivalve Transmissible Neoplasia in Soft-Shell Clams (Mya arenaria) in the Puget Sound Using Hemolymph and eDNA Surveys
Weinandt, S. A.; Child, Z. J.; Lartey, D.; Santos, A.; Maxfield, H.; Sevigny, J. K.; Garrett, F. E. S.; Smith, P. D.; Giersch, R. M.; Hart, S. F. M.; Perez, F.; Rabins, L.; Kaiser, S.; Boyar, A.; Newton, J.; Kerr, J.; Dimond, J. L.; Metzger, M. J.
10.1101/2024.12.03.626659 — ecology — Posted on 2024-12-07
3979 ANKRD5: a key component of the axoneme required for spermmotility and male fertility
Yu, S.; Yin, G.; Jin, P.; Zhang, W.; Tian, Y.; Xu, X.; Shao, T.; Li, Y.; Sun, F.; Zhu, Y.; Wang, F.
10.1101/2024.12.03.626701 — developmental biology — Posted on 2024-12-07
3981 Assessing Behavioral and Neural Correlates of Change Detection in Spatialized Acoustic Scenes
Poole, K. C.; Cappotto, D.; Martin, V.; Sztandera, J.; Chait, M.; Picinali, L.; Shiell, M.
10.1101/2024.12.03.626637 — neuroscience — Posted on 2024-12-07
3985 Centella asiatica Tissue Culture-Derived Extracellular Vesicles: A Multifaceted Approach to Skincare Applications
Chang, T.-M.; Wu, C.-C.; Huang, H.-C.; Wang, S.-S.; Chuang, C.-H.; Kao, P.-L.; Tang, W.-H.; Liu, L. T.-C.; Qiu, W.-Y.; Percec, I.; Chen, C.; Kuo, T.-Y.
10.1101/2024.12.03.624435 — pharmacology and toxicology — Posted on 2024-12-07
3986 PISA: versatile microscope for 3D single molecule light sheet imaging
Taniguchi, Y.; Nishimura, K.; Yoshida, Y.; Kim, S.; Kamarulzaman, L.; Priest, D. G.; Ohno, M.
10.1101/2024.12.05.625331 — biophysics — Posted on 2024-12-07
3987 Comprehensive Longitudinal ctDNA Monitoring in Metastatic Cancer Patients Treated with an Individualized Neoantigen-directed Vaccine
Schenk, D.; Davis, M. J.; Zhou, R.; Mantilla, A.; Galbraith, M.; Spiro, O.; Petrillo, O.; Faria do Valle, I.; Ferguson, A. R.; Jooss, K.; Dhanik, A.
10.1101/2024.12.04.626817 — genomics — Posted on 2024-12-07
3990 Peripheral immune cell response to stimulation stratifies Parkinson's disease progression from prodromal to clinical stages
Mark, J. R.; Titus, A.; Staley, H. R.; Alvarez, S.; Mahn, S.; McFarland, N.; Tansey, M. G.; Wallings, R.
10.1101/2024.12.05.625499 — neuroscience — Posted on 2024-12-07
3991 Lesions of anterior cingulate cortex disrupt an electrophysiological signature of reward processing in humans
Oerlemans, J.; Alejandro, R. J.; Hemelsoet, D.; Genbrugge, E.; Bouche, K.; Defreyne, L.; De Herdt, V.; Holroyd, C. B.
10.1101/2024.12.04.626789 — neuroscience — Posted on 2024-12-07
3992 The interplay between executive functions and updating predictive representations
Pedraza, F.; Vekony, T.; Farkas, B. C.; Haesebaert, F.; Phelipon, R.; Mihalecz, I.; Janacsek, K.; Tillmann, B.; Anders, R.; Plancher, G.; Nemeth, D.
10.1101/2024.12.05.626969 — neuroscience — Posted on 2024-12-07
3993 Sense of control buffers against stress
Fielder, J. C.; Shi, J.; McGlade, D.; Huys, Q. J.; Steinbeis, N.
10.1101/2024.12.05.626945 — neuroscience — Posted on 2024-12-07
3994 Collapse of Interictal Suppressive Networks Permits Seizure Spread
Makhoul, G. S. P.; Doss, D. J.; Johnson, G. W.; Withers, C. P.; Cavender, A. C.; Hidalso Monroy Lerma, B.; Reda, A.; Bibro, C. E.; Liao, E.; Kang, H.; Dawant, B. M.; Reddy, S. B.; Crudele, A. N.; Constantinidis, C.; Roberson, S. W.; Bick, S. K.; Morgan, V. L.; Englot, D. J.
10.1101/2024.12.04.626580 — neuroscience — Posted on 2024-12-07
3996 Ozboneviz: An Australian Precedent in FAIR 3D Imagery and Extended Biodiversity Collections
Weisbecker, V.; Fusco, D.; Ingleby, S.; Lambrides, A. B. J.; Manne, T.; Maguire, K.; O'Connor, S.; Peachey, T. J.; Samper Carro, S. C.; Stemmer, D.; Ristevski, J.; van Zoelen, J. D.; Viacava, P.; Yates, A. M.; Mein, E.
10.1101/2024.12.04.626889 — zoology — Posted on 2024-12-07
3998 Reporting quality of quantitative polymerase chain reaction (qPCR) methods in scientific publications
Drude, N. I.; Baselly, C.; Gazda, M. A.; May, J.-N.; Tienken, L. B.; Abbasi, P.; Weissgerber, T.; Burgess, S.
10.1101/2024.12.04.626769 — genetics — Posted on 2024-12-07
4002 Mechanism of Dimer Selectivity and Binding Cooperativity of BRAF inhibitors
Clayton, J.; Romany, A.; Matenoglou, E.; Gavathiotis, E.; Poulikakos, P. I.; Shen, J.
10.1101/2023.12.12.571293 — biophysics — Posted on 2024-12-07
4003 Dimeric assembly of F1-like ATPase for the gliding motility of Mycoplasma
Toyonaga, T.; Kato, T.; Kawamoto, A.; Miyata, T.; Kawakami, K.; Fujita, J.; Hamaguchi, T.; Namba, K.; Miyata, M.
10.1101/2024.06.11.597861 — microbiology — Posted on 2024-12-07
4009 SOI: Robust identification of orthologous synteny with the Orthology Index and broad applications in evolutionary genomics
Zhang, R.-G.; Shang, H.-Y.; Milne, R. I.; Almeida-Silva, F.; Chen, H.; Zhou, M.-J.; Shu, H.; Jia, K.-H.; Van de Peer, Y.; Ma, Y.-P.
10.1101/2024.08.22.609065 — genomics — Posted on 2024-12-07
4014 Modeling and Correction of Protein Conformational Disease in iPSC-derived Neurons through Personalized Base Editing
Konishi, C. T.; Moulayes, N.; Butola, T.; Zhang, V.; Kagan, D.; Yang, Q.; Pressler, M.; Dirvin, B. G.; Devinsky, O.; Basu, J.; Long, C.
10.1101/2024.01.17.576134 — molecular biology — Posted on 2024-12-07
4015 Cryo-EM reveals that cardiac IGLV6-derived AL fibrils can be polymorphic
Bassett, P. T.; Nguyen, B. A.; Singh, V.; Garrett, P.; Moresco, J. J.; Kaur, G.; Afrin, S.; Pekała, M.; Saelices, L.
10.1101/2024.12.04.626857 — molecular biology — Posted on 2024-12-07
4019 Decoding the hidden variabilities in mPFC descending pathways across emotional states
Lai, C.-H.; Park, G.; Xu, P.; Sun, X.; Ge, Q.; Jin, Z.; Betts, S.; Liu, X.; Liu, Q.-s.; Simha, R.; Zeng, C.; Lu, H.; Du, J.
10.1101/2024.05.28.596238 — neuroscience — Posted on 2024-12-07
4020 Driver lines for studying associative learning in Drosophila
Shuai, Y.; Sammons, M.; Sterne, G. R.; Hibbard, K.; Yang, H.; Yang, C.-P.; Managan, C.; Siwanowicz, I.; Lee, T.; Rubin, G. M.; Turner, G. C.; Aso, Y.
10.1101/2023.09.15.557808 — neuroscience — Posted on 2024-12-07
4022 Reconstructing Circuit Connectivity from in vivo Spike Trains Using Deep Domain-Adaptive Matching
Sheng, K.; Zhang, S.; Beau, M.; Qu, P.; Yang, L.; Liu, X.; He, L.; Zhang, Y.; Ma, L.; Du, K.
10.1101/2022.10.03.510694 — neuroscience — Posted on 2024-12-07
4024 Visual mental imagery in typical imagers and in aphantasia: A millimeter-scale 7-T fMRI study
Liu, J.; Zhan, M.; Hajhajate, D.; Spagna, A.; Dehaene, S.; Cohen, L.; Bartolomeo, P.
10.1101/2023.06.14.544909 — neuroscience — Posted on 2024-12-07
4025 A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring
Voitiuk, K.; Seiler, S. T.; Pessoa de Melo, M.; Geng, J.; van der Molen, T.; Hernandez, S.; Schweiger, H. E.; Sevetson, J. L.; Parks, D. F.; Robbins, A.; Torres-Montoya, S.; Ehrlich, D.; Elliott, M. A. T.; Sharf, T.; Haussler, D.; Mostajo-Radji, M. A.; Salama, S. R.; Teodorescu, M.
10.1101/2024.03.15.585237 — neuroscience — Posted on 2024-12-07
4028 Two-Photon NAD(P)H-FLIM reveals unperturbed energy metabolism of Ascaris suum larvae, in contrast to host macrophages upon artemisinin derivatives exposure
Musimbi, Z. D.; Kundik, A.; Krucken, J.; Hauser, A. E.; Rausch, S.; Seeberger, P. H.; Niesner, R.; Leben, R.; Hartmann, S.
10.1101/2024.08.30.610452 — biophysics — Posted on 2024-12-07
4029 The brain selectively allocates energy to functional brain networks under cognitive control
Saberi, M.; Rieck, J. R.; Golafshan, S.; Grady, C. L.; Misic, B.; Dunkley, B. T.; Khatibi, A.
10.1101/2024.12.06.627178 — neuroscience — Posted on 2024-12-06
4031 Heterogeneous, temporally consistent, and plastic brain development after preterm birth
Thalhammer, M.; Seidlitz, J.; Neubauer, A.; Menegaux, A.; Schmitz-Koep, B.; Di Biase, M. A.; Schulz, J.; Dorfschmidt, L.; Bethlehem, R. A. I.; Alexander-Bloch, A.; Adamson, C. L.; Ball, G.; Zimmer, C.; Daamen, M.; Boecker, H.; Bartmann, P.; Wolke, D.; Hedderich, D. M.; Sorg, C.
10.1101/2024.12.06.627134 — neuroscience — Posted on 2024-12-06
4034 Adult visual deprivation engages associative, presynaptic plasticity of thalamic input to cortex
Murase, S.; Severin, D.; Dye, L.; Mesik, L.; Moreno, C.; kirkwood, a.; Quinlan, E. M.
10.1101/2024.12.04.626829 — neuroscience — Posted on 2024-12-06
4036 Volitional Regulation and Transferable Patterns of Midbrain Oscillations
Lu, H.-Y.; Zhao, Y.; Stealey, H. M.; Barnett, C. R.; Tobler, P. N.; Santacruz, S. R.
10.1101/2024.12.04.626827 — neuroscience — Posted on 2024-12-06
4037 The association between oscillatory burst features and deviations during human working memory
Kavanaugh, B.; Vigne, M. M.; Thorpe, R.; Legere, C.; Acuff, W. L.; Vaughan, N.; Tirrell, E.; Haegens, S.; Carpenter, L.; Jones, S.
10.1101/2024.12.06.622989 — neuroscience — Posted on 2024-12-06
4040 Assessing target genes for homing suppression gene drive
Xu, X.; Fang, J.; Chen, J.; Yang, J.; Yang, X.; Hou, S.; Sun, W.; Champer, J.
10.1101/2024.12.06.627146 — genetics — Posted on 2024-12-06
4042 A census of RNA-dependent proteins in yeast
Waber, N. B.; Seidler, J.; Thelen, F.; Timm, T.; Lochnit, G.; Strasser, K.; Kilchert, C.
10.1101/2024.12.06.627129 — molecular biology — Posted on 2024-12-06
4045 BEVA2.0: Modular Assembly of Golden Gate-Compatible Vectors with Expanded Utility for Genetic Engineering
Geddes, B. A.; Williamson, R.; Schumacher, J.; Ardi, A.; Levin, G.; Cervenka, E.; Huang, R.; diCenzo, G. C.
10.1101/2024.12.04.626608 — synthetic biology — Posted on 2024-12-06
4050 RNA-mediated MYC multimerization suppresses innate immune signaling
Uhl, L.; Aziba, A.; Loebbert, S.; Russell, T.; Kannan, T.; Valanju, O. R.; Schuelein-Voelk, C.; de Martines, T.; Montesinos, F.; Bolz, M.; Cossa, G.; Endres, T.; Solvie, D.; Krenz, B.; Maric, H. M.; Papadopoulos, D.; Vos, S. M.; Eilers, M.
10.1101/2024.12.06.627168 — molecular biology — Posted on 2024-12-06
4053 Heparanase, a host gene that potently restricts retrovirus transcription
Waxman, B.; Salka, K.; Timilsina, U.; Umthong, S.; Shukla, D.; Stavrou, S.
10.1101/2024.12.06.627204 — microbiology — Posted on 2024-12-06
4054 Protozoal populations drive system-wide variation in the rumen microbiome
Kobel, C. M.; Leu, A.; Vera-Ponce de Leon, A.; Oyas, O.; Lai, W.; Altshuler, I.; Hagen, L. H.; Wollenberg, R. D.; Bakshani, C. R.; Willats, W. G. T.; Nicoll, L.; McIlroy, S. J.; Hvidsten, T. R.; Schmidt, O.; Greening, C.; Tyson, G. W.; Roehe, R.; Aho, V. T. E.; Pope, P. B.
10.1101/2024.12.05.626740 — microbiology — Posted on 2024-12-06
4055 Cultivation and molecular characterization of Foley catheterized urine, clean catch urine, and vaginal swabs from pregnant women prior to delivery
Greenberg, J. M.; Romero, R.; Alhousseini, A.; Winters, A. D.; Tarca, A. L.; Gilbert, N. M.; Gomez-Lopez, N.; Hassan, S. S.; Theis, K. R.
10.1101/2024.12.05.627013 — microbiology — Posted on 2024-12-06
4056 Easy come, easier go: mapping the loss of flagellar motility across the tree of life
Philip, J. S.; Grewal, S.; Scadden, J.; Puente Lelievre, C.; Matzke, N. J.; McNally, L.; Baker, M. A.
10.1101/2024.12.05.626484 — microbiology — Posted on 2024-12-06
4057 Vgamma1+ gammadelta T cell-derived IL-4 initiates CD8 T cell immunity
Le, S.; Murphy, D.; Liu, S.; Ge, Z.; May, R.; Cozijnsen, A.; Burn, T.; Jennison, C.; Bachem, A.; Xu, C.; Koay, H.-F.; Schroeder, J.; Gras, S.; Cockburn, I. A.; Bedoui, S.; Mackay, L. K.; Mcfadden, G. I.; Fernandez-Ruiz, D.; Heath, W. R.; Beattie, L.
10.1101/2024.12.06.627130 — immunology — Posted on 2024-12-06
4058 POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons
Talbi, R.; Stincic, T. L.; Ferrari, K.; Ji Hae, C.; Walec, K.; Medve, E.; Gerutshang, A.; Leon, S.; McCarthy, E. A.; Ronnekleiv, O. K.; Kelly, M. J.; Navarro, V. M.
10.1101/2024.02.18.580873 — neuroscience — Posted on 2024-12-06
4061 Global analysis of protein and small-molecule substrates of ubiquitin-like proteins (UBLs)
Shao, G.; Chen, Z.-L.; Lu, S.; Wu, Q.; Yao, S.; Wang, J.; Ma, Y.; Sui, J.-H.; Chi, H.; Qi, X.; He, S.-M.; Du, L.-L.; Dong, M.-Q.
10.1101/2024.12.05.626486 — biochemistry — Posted on 2024-12-06
4062 Disruption of LEDGF/p75-directed integration derepresses antisensetranscription of the HIV-1 genome
Tedbury, P. R.; Mahboubi, D.; Puray-Chavez, M.; Shah, R.; Ukah, O. B.; Wahoski, C. C.; Fadel, H. J.; Poeschla, E. M.; Gao, X.; McFadden, W. M.; Gaitanidou, M.; Kesesidis, N.; Kirby, K. A.; Vanderford, T. H.; Kvaratskhelia, M.; Achuthan, V.; Behrens, R. T.; Engelman, A. N.; Sarafianos, S. G.
10.1101/2024.12.06.627169 — microbiology — Posted on 2024-12-06
4063 Exploring virus-host interactions through combined proteomic approaches identifies BANF1 as a new essential factor for African Swine Fever Virus.
Dupre, J.; Dolata, K. M.; Pei, G.; Molouki, A.; Goatley, L. C.; Kuchler, R.; Soh, T. K.; Bosse, J. B.; Fablet, A.; Dimna, M. L.; Karadjian, G.; Hirchaud, E.; Netherton, C. L.; Dixon, L. K.; Reis, A. L.; Vitour, D.; Potier, M.-F. L.; Karger, A.; Caignard, G.
10.1101/2024.12.05.627126 — microbiology — Posted on 2024-12-06
4064 Harnessing the Biosynthetic Diversity of Actinomycetes: Discovery of Unique Natural Products through Comparative Genomic and Metabolic Analysis
Kikuchi, Y.; Tsutsumi, H.; Watanabe, Y.; Nakahara, H.; Ito, S.; Noguchi, Y.; Awano, Y.; Kasuga, M.; Iwatsuki, M.; Hirose, T.; Sunazuka, T.; Inahashi, Y.
10.1101/2024.12.06.627119 — microbiology — Posted on 2024-12-06
4066 Mitophagosomes induced during EV-D68 infection promote viral nonlytic release
Jassey, A.; Paudel, B.; Wagner, M.; Pollack, N.; Chang, I.-T.; Godoy-Ruiz, R.; Weber, D.; Jackson, W. T.
10.1101/2024.12.05.627125 — microbiology — Posted on 2024-12-06
4067 In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals
Capoferri, A. A.; Sklutuis, R.; Famuyiwa, T. O.; Pathak, S.; Li, R.; Rausch, J. W.; Luke, B. T.; Hoh, R.; Deeks, S. G.; Mellors, J. W.; Coffin, J. M.; Groebner, J. L.; Romerio, F.; Kearney, M. F.
10.1101/2024.12.06.627170 — microbiology — Posted on 2024-12-06
4068 Improved Efficiency of Two-Step Amplicon PCR Using an Acoustic Liquid Handler
Benz, B. R.; Lopez Echartea, E.; Whitaker, B. K.; Baldwin, T.; Geddes, B. A.
10.1101/2024.12.06.627172 — microbiology — Posted on 2024-12-06
4073 IGFs regulate cancer cell immune evasion in prostate cancer
Nandakumar, A. M.; Barberis, A.; Kim, J.; Lang, C. R.; Mills, J. V.; Rieunier, G.; Doultsinos, D.; Taylor, A.; Jainarayanan, A.; Phyu, S. M.; Campo, L.; Easton, A.; Parkes, E.; James, T.; Hamdy, F. C.; Verrill, C.; Mills, I. G.; Macaulay, V. M.
10.1101/2024.12.03.626600 — cancer biology — Posted on 2024-12-06
4075 Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Bienkowska, K. J.; Gallardo, S.; Zainal, N.; Ellis, M.; Lopez, M.-A.; Austine, J.; Pittla, S.; Chee, S. J.; Alzetani, A.; Shaw, E. C.; Ottensmeier, C. H.; Thomas, G. J.; Hanley, C. J.
10.1101/2024.12.03.626626 — cancer biology — Posted on 2024-12-06
4077 High-efficiency genomic mapping of chromatin-associated targets with CUT&RUN
Firestone, T. M.; Venters, B. J.; Novitzky, K.; Albertorio-Saez, L. M.; Barnes, C. A.; Fedder-Semmes, K. N.; Hall, N. W.; Hickman, A. R.; Kaderli, M.; Windham, C. L.; Marunde, M. R.; Maryanski, D. N.; Noll, K.; Shannon, L.; Spengler, J.; Cowles, M. W.; Sun, Z.-W.; Keogh, M.-C.; Johnstone, A. L.; Weinzapfel, E. N.; Sun, L.
10.1101/2024.12.03.626419 — genomics — Posted on 2024-12-06
4078 SARS-CoV-2 predation of Golgi-bound PI4P primes the massive activation of the DNA Damage Response kinase ATM in the cytoplasm
Rebendenne, A.; Soulet, C.; Valadao, A. L. C.; Bonaventure, B.; McKellar, J.; Moncorge, O.; Goujon, C.; Moriel-Carretero, M.
10.1101/2024.12.05.626967 — microbiology — Posted on 2024-12-06
4080 RNA-programmable cell type monitoring and manipulation in the human cortex with CellREADR
Matthews, E. A.; Russ, J. B.; Qian, Y.; Zhao, S.; Thompson, P.; Methani, M.; Vestal, M. L.; Huang, Z. J.; Southwell, D. G.
10.1101/2024.12.03.626590 — neuroscience — Posted on 2024-12-06
4083 A Method for the Combined Functional Assessment of Photoreceptors and Ganglion Cells in Acute Retinal Explants
He, X.; da Costa Moura, J. C.; Fernandez, P. G.; Glaeser, P.; Wang, L.; Paquet-Durand, F.; Zhao, Z.; Schwarz, C.
10.1101/2024.12.03.626609 — neuroscience — Posted on 2024-12-06
4084 Exercise alleviates liver senescence but does not outmatch the effect of dietary restriction in diet-induced MASLD
Katsarou, A.; Papadopoulos, G.; Moustakas, I. I.; Papadopetraki, A.; Moustogiannis, A.; Legaki, A.-I.; Giannousi, E.; Veroutis, D.; Kotsinas, A.; Gorgoulis, V.; Philippou, A.; Koutsilieris, M.; Chatzigeorgiou, A.
10.1101/2024.12.03.626591 — physiology — Posted on 2024-12-06
4085 Combined inhibition of MDM2 and PARP lead to a synergistic anti-tumoral response in p53 wild-type rhabdomyosarcoma models
Pons, G.; Zarzosa, P.; Gallo-Oller, G.; Wenz, A.; Lapins, M.; Garcia-Gilabert, L.; Sansa-Girona, J.; Navarro, N.; Segura, M. F.; Soriano, A.; Guillen, G.; Hladun, R.; Sanchez de Toledo, J.; Gallego, S.; Carreras-Puigvert, J.; Moreno, L.; Roma, J.
10.1101/2024.12.03.626050 — cancer biology — Posted on 2024-12-06
4087 Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle
Tomasini, C.; Cuche, C.; Ay, S.; Collard, M.; Cui, B.; Rashid, M.; Bhattacharjee, S.; Buchrieser, J.; Luchsinger, C.; Bertelli, C.; Uversky, V.; Diaz-Griffero, F.; Di Nunzio, F.
10.1101/2024.10.06.616889 — microbiology — Posted on 2024-12-06
4089 Telomerase-Dependent Ageing In The Zebrafish Brain
Martins, R. R.; Besse, S.; Ellis, P. S.; Hartopp, N.; Mughal, N.; Evans, O.; Wahib, M. H.; Yazigan, Z.; Mortiboys, H. J.; Rera, M.; Henriques, C. M.
10.1101/2022.05.24.493215 — cell biology — Posted on 2024-12-06
4090 Dnmt3a-mediated de novo methylation balances Th1 and Tfh memory cell plasticity and functionality
Perkins, B.; Novis, C.; Baessler, A.; Sircy, L. M.; Thomas, M. M.; Richens, A. W.; Fuchs, B.; Nguyen, N. X.; Fint, K.; Varley, K. E.; Hale, J. S.
10.1101/2024.12.03.623450 — immunology — Posted on 2024-12-06
4092 Cross-subject Mapping of Neural Activity with Restricted Boltzmann Machines
Yang, H.; Angjelichinoski, M.; Wu, S.; Putney, J.; Sponberg, S.; Tarokh, V.
10.1101/2023.04.14.536854 — neuroscience — Posted on 2024-12-06
4093 Two Key Actinomycetota Taxa in the Human Gut Microbiota are Associated with Schistosoma mansoni Infection Burden
Appiah-Twum, F.; Okyere, L.; Sumboh, J. G.; Osabutey, D.; Ismail, R. B. Y.; Darko, H.; Ashong, Y.; Wilson, M. D.; Akorli, J. A.
10.1101/2024.12.03.626529 — genomics — Posted on 2024-12-06
4094 The comprehensive detection of hemoglobinopathy variants via long-read sequencing
Xiang, J.; Peng, J.; Sun, X.; Jiang, C.; Zhao, H.; Guo, Y.; Xu, H.; Gu, S.; Ye, H.; You, L.; Huang, X.; Chen, S.; Zhu, B.; Peng, Z.
10.1101/2024.12.03.626522 — genomics — Posted on 2024-12-06
4095 Chromosome-level Assemblies of Three Candidatus Liberibacter solanacearum Vectors: Dyspersa apicalis, Dyspersa pallida, and Trioza urticae (Hemiptera: Psylloidea)
Heaven, T.; Mathers, T. C.; Mugford, S. T.; Jordan, A.; Lethmayer, C.; Nissinen, A. I.; Hogetveit, L.-A.; Highet, F.; Soria-Carrasco, V.; Sumner-Kalkun, J.; Goldberg, J. K.; Hogenhout, S. A.
10.1101/2024.12.03.626329 — genomics — Posted on 2024-12-06
4098 Turncoat antibodies unmasked in a model of autoimmune demyelination: from biology to therapy
Taghipour-Mirakmahaleh, R.; Morin, F.; Zhang, Y.; Bourhoven, L.; Beland, L.-C.; Zhou, Q.; Jaworski, J.; Park, A.; Dominguez, J. M.; Corbeil, J.; Flanagan, E.; Marignier, R.; Larochelle, C.; Kerfoot, S.; Vallieres, L.
10.1101/2024.12.03.623846 — immunology — Posted on 2024-12-06
4101 Bluetongue virus serotype 12 in the Netherlands in 2024 - A BTV serotype reported in Europe for the first time
van den Brom, R.; Santman-Berends, I.; van der Heijden, M. G.; Harders, F.; Engelsma, M. Y.; van Gennip, R.; Maris-Veldhuis, M.; Feddema, A.-J.; Petterson, K.; Golender, N.; Spierenburg, M.; van Rijn, P. A.; Holwerda, M.
10.1101/2024.12.03.626362 — zoology — Posted on 2024-12-06
4104 Explainable deep neural networks for predicting sample phenotypes from single-cell transcriptomics
Martorell-Marugan, J.; Lopez-Dominguez, R.; Villatoro-Garcia, J. A.; Toro-Dominguez, D.; Chierici, M.; Jurman, G.; Carmona-Saez, P.
10.1101/2024.12.03.626549 — bioinformatics — Posted on 2024-12-06
4107 The R-loop Grammar predicts R-loop formation under different topological constraints
Ferrari, M. M.; Poznanovic, S.; Riehl, M.; Lusk, J.; Hartono, S.; Gonzalez, G.; Chedin, F.; Vazquez, M.; Jonoska, N.
10.1101/2024.12.03.626533 — genomics — Posted on 2024-12-06
4108 From Pigments to Precision: Exploring Genetic Transformation and Genome Editing in Wheat and Barley
Prusty, M. R.; Shatil-Cohen, A.; Kumar, R.; Sharma, D.; Minz-Dub, A.; Ezrati, S.; Hihinashvili, A.; Sharon, A.
10.1101/2024.12.03.626565 — genomics — Posted on 2024-12-06
4109 Spatiotemporal distribution of the glycoprotein pherophorin II reveals stochastic geometry of the growing ECM of Volvox carteri
von der Heyde, B.; Srinivasan, A.; Birwa, S. K.; von der Heyde, E. L.; Hohn, S. S.; Goldstein, R. E.; Hallmann, A.
10.1101/2024.12.06.625376 — developmental biology — Posted on 2024-12-06
4111 Early changes in the properties of CA3 engram cells explored with a novel viral tool
Cupolillo, D.; Grosjean, N.; Marneffe, C.; Viotti, J.; Reynaud, C.; Deforges, S.; Carta, M.; Mulle, C.
10.1101/2024.11.29.625977 — neuroscience — Posted on 2024-12-06
4112 Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast
Sottnik, J. L.; Shackleford, M. T.; Nesiba, C. S.; Richer, A. L.; Swartz, J. M.; Rowland, C. E.; Musick, M.; Fu, R.; Opresko, P. L.; Mehrotra, S.; Hesselberth, J. R.; Diamond, J. R.; Sikora, M. J.
10.1101/2023.10.29.564555 — cancer biology — Posted on 2024-12-06
4113 Identification of Inhibitors of Chikungunya virus nsP2 ATPase
Navarro, H.; Scott, J. E.; Smith, G. R.; Ghiabi, P.; Gibson, E.; Loppnau, P.; Harding, R. J.; Hossain, M. A.; Bose, M. R.; Pearce, K. H.; Merten, E. M.; Willson, T. M.; Brown, P. J.
10.1101/2024.12.02.625520 — biochemistry — Posted on 2024-12-06
4114 Dynamic metabolic and molecular changes during seasonal shrinking in Sorex araneus
Thomas, W. R.; Baldoni, C.; Zeng, Y.; Carlson, D.; Holm-Jacobsen, J.; Muturi, M.; Elverfeldt, D.; Nieland, J.; Dechmann, D. K. N.; Corthals, A.; Davalos, L.
10.1101/2023.10.02.560485 — genetics — Posted on 2024-12-06
4116 LysM-RLK plays an ancestral symbiotic function in plants
Teyssier, E.; Grat, S.; Landry, D.; Ouradou, M.; Rich, M. K.; Fort, S.; Keller, J.; Lefebvre, B.; Delaux, P.-M.; Mbengue, M.
10.1101/2024.01.16.575821 — plant biology — Posted on 2024-12-06
4118 PHENOTYPIC CHARACTERIZATION AND BACTERIAL INTERACTIONS OF THE COMPLEX MICROBIAL POPULATION IN URINARY DOUBLE-J CATHETERS
Farizano, J. V.; Castagnaro, E. N.; Arroyo-Egea, J. T.; Aparicio, J. D.; Vallejos, C. N.; Hebert, E. M.; Saavedra, L. N.; Rapisarda, V. A.; Villegas, J. M.; Grillo Puertas, M. N.
10.1101/2024.12.04.626871 — microbiology — Posted on 2024-12-06
4119 Differential GTP-dependent in-vitro polymerization of recombinant Physcomitrella FtsZ proteins
Milferstaedt, S. W. L.; Joest, M.; Bohlender, L. L.; Hoernstein, S. N. W.; Oezdemir, B.; Decker, E. L.; van der Does, C.; Reski, R.
10.1101/2024.02.14.580282 — plant biology — Posted on 2024-12-06
4121 CGC1, a new reference genome for Caenorhabditis elegans
Ichikawa, K.; Shoura, M. J.; Artiles, K. L.; Jeong, D.-E.; Owa, C.; Kobayashi, H.; Suzuki, Y.; Kanamori, M.; Toyoshima, Y.; Iino, Y.; Rougvie, A. E.; Wahba, L.; Fire, A. Z.; Schwarz, E. M.; Morishita, S.
10.1101/2024.12.04.626850 — genomics — Posted on 2024-12-06
4122 Fatty Acid Metabolism and The Oxidative Stress Response Support Bacterial Predation
Jain, R.; Le, N.-H.; Bertaux, L.; Baudry, J.; Bibette, J.; Denis, Y.; Habermann, B. H.; Mignot, T.
10.1101/2023.12.11.571100 — microbiology — Posted on 2024-12-06
4125 Detection of mitotic neuroblasts provides additional evidence of steady state neurogenesis in the adult small intestinal myenteric plexus
Gorecki, A. M.; Slosberg, J.; Hong, S. M.; Seika, P.; Puttapaka, S.; Migden, B.; Gulko, A.; Singh, A.; Zhang, C.; Gurumurthy, R.; Kulkarni, S.
10.1101/2022.11.14.516462 — neuroscience — Posted on 2024-12-06
4133 Hybridogenetic reproduction of Pelophylax water frogs from different R-E hemiclonal population systems from Eastern Ukraine: selective mortality, clonal and ploidy diversity
Fedorova, A.; Pustovalova, E.; Drohvalenko, M.; Biriuk, O.; Dolezalkova-Kastankova, M.; Kravchenko, M.; Korshunov, O.; Mikulicek, P.; Choleva, L.; Holovnia, D.; Dedukh, D.; Shabanov, D.
10.1101/2024.12.03.626604 — zoology — Posted on 2024-12-06
4134 Pharmacological characterisation of allosteric modulators at human mGlu5
Razzak, M.; Tran, K.; McCague, R.; Sengmany, K.; Kos, J.; Langiu, M.; Li, B.; Hellyer, S. D.; Gregory, K. J.
10.1101/2024.12.05.627101 — pharmacology and toxicology — Posted on 2024-12-06
4135 The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins
Khalil, M. I.; Wang, J.; Yang, C.; Vu, L.; Yin, C.; Chadha, S.; Nabors, H.; Vocelle, D.; May, D. G.; Chrisopolus, R. J.; Zhou, L.; Roux, K. G.; Bernard, M. P.; Mi, Q.-S.; Pyeon, D.
10.1101/2024.11.29.626106 — cancer biology — Posted on 2024-12-06
4136 Time- and Dose-dependent Effects of CIGB-300 in the lung squamous cell carcinoma proteomics.
Garcia, L. E.; Dai, L.; Rodriguez-Ulloa, A.; Yi, Y.; Gonzalez, L. J.; Besada, V.; Li, W.; Perea, S. E.; Perera, Y.
10.1101/2024.12.03.626528 — cancer biology — Posted on 2024-12-06
4139 Microvalve-based devices for flow-free gradient generators
Bohec, P.; Dupuy, F.; Tishkova, V.; Seveau de Noray, V.; Valignat, M.-P.; Theodoly, O.
10.1101/2024.12.03.626578 — biophysics — Posted on 2024-12-06
4146 Leucine zipper-based SAIM imaging identifies therapeutic agents to disrupt the cancer cell glycocalyx for enhanced immunotherapy
Park, S.; Paek, J. H.; Colville, M. J.; Huang, L.-T.; Struzyk, A. P.; Womack, S. J.; Neelamegham, S.; Reesink, H. L.; Paszek, M. J.
10.1101/2024.12.05.627089 — bioengineering — Posted on 2024-12-06
4147 De novo design of potent CRISPR-Cas13 inhibitors
Taveneau, C.; Chai, H. X.; D'Silva, J.; Bamert, R. S.; Hayes, B. K.; Calvert, R. W.; Curwen, D. J.; Munder, F.; Martin, L. L.; Barr, J. J.; Grinter, R.; Knott, G. J.
10.1101/2024.12.05.626932 — biochemistry — Posted on 2024-12-06
4148 Inhibiting heme-piracy by pathogenic Escherichia coli using de novo-designed proteins
Fox, D. R.; Asadollahi, K.; Samuels, I. G.; Spicer, B.; Kropp, A.; Lupton, C.; Lim, K.; Wang, C.; Venugopal, H.; Dramicanin, M.; Knott, G. J.; Grinter, R.
10.1101/2024.12.05.626953 — biochemistry — Posted on 2024-12-06
4149 Comparative genomics of Rickettsiella bacteria reveal variable metabolic traits involved in symbiotic interactions with arthropods
Floriano, A. M. M.; El-Filali, A.; Amoros, J.; Buysse, M.; Jourdan-Pineau, H.; Sprong, H.; Kohl, R.; Dirks, R. P.; Schaap, P.; Koehorst, J.; Nijsse, B.; Bouchon, D.; Daubin, V.; Vavre, F.; Duron, O.
10.1101/2024.12.03.626579 — evolutionary biology — Posted on 2024-12-06
4150 Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a interneurons
Elder, N. H.; Majd, A.; Bulger, E. A.; Samuel, R. M.; Zholudeva, L. V.; McDevitt, T. C.; Fattahi, F.
10.1101/2024.12.03.626573 — developmental biology — Posted on 2024-12-06
4152 High-Throughput Quantification of miRNA-3'-Untranslated-Region Regulatory Effects
Mastriano, S.; kanoria, S.; Rennie, W.; Liu, C.; Li, D.; Cheng, J.; Ding, Y.; Lu, J.
10.1101/2024.12.05.626985 — molecular biology — Posted on 2024-12-06
4153 Dynamic regulation of NAT10-mediated mRNA acetylation at synapses by learning and memory in mouse hippocampus
Zhou, H.-Q.; Zhang, J.-W.; Zhu, Z.; Lin, W.-P.; Jin, H.-J.; Ding, Y.-Y.; Chen, D.-S.; Yin, D.-M.
10.1101/2024.06.01.596932 — neuroscience — Posted on 2024-12-06
4156 A single-cell atlas of transcriptome changes in the intestinal epithelium at the suckling-to-weaning transition
Malonga, T.; Knudsen, C.; Lhuillier, E.; Aymard, P.; Jones, E.; Lencina, C.; Despeyroux, M.; Riant, E.; Cabau, C.; Ivy, A.; Loving, C. L.; Vialaneix, N.; Beaumont, M.
10.1101/2024.12.02.626361 — physiology — Posted on 2024-12-06
4157 The TriScan: fast and sensitive 3D confocal fluorescence imaging using a simple optical design
Van den Eynde, R.; Verheyen, J.; Miclea, P. S.; Lazar, J.; Vandenberg, W.; Dedecker, P.
10.1101/2023.04.11.536163 — biophysics — Posted on 2024-12-06
4159 Balancing Locality and Reconstruction in Protein Structure Tokenizer
Zhang, J.; Meynard-Piganeau, B.; Gong, J.; Cheng, X.; Luo, Y.; Ly, H.; Song, L.; Xing, E. P.
10.1101/2024.12.02.626366 — bioinformatics — Posted on 2024-12-06
4160 Diverse prey capture strategies in teleost larvae
Mearns, D. S.; Hunt, S. A.; Schneider, M. W.; Parker, A. V.; Stemmer, M.; Baier, H.
10.1101/2023.10.03.560453 — animal behavior and cognition — Posted on 2024-12-06
4164 C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice
Tanaka, T.; Sasaki, N.; Krisnanda, A.; Amin, H. Z.; Ito, K.; Horibe, S.; Matsuo, K.; Hirata, K.-i.; Nakayama, T.; Rikitake, Y.
10.1101/2024.08.16.608245 — immunology — Posted on 2024-12-06
4166 Synapse profiling of identified neurons in the Drosophila brain
Wu, H.; Maekawa, Y.; Eno, S.; Kondo, S.; Yamagata, N.; Tanimoto, H.
10.1101/2024.12.02.626511 — neuroscience — Posted on 2024-12-06
4167 A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring
Voitiuk, K.; Seiler, S. T.; Pessoa de Melo, M.; Geng, J.; van der Molen, T.; Hernandez, S.; Schweiger, H. E.; Sevetson, J. L.; Parks, D. F.; Robbins, A.; Torres-Montoya, S.; Ehrlich, D.; Elliott, M. A. T.; Sharf, T.; Haussler, D.; Mostajo-Radji, M. A.; Salama, S. R.; Teodorescu, M.
10.1101/2024.03.15.585237 — neuroscience — Posted on 2024-12-06
4169 Octopamine signals coordinate the spatial pattern of presynaptic machineries in the Drosophila mushroom bodies
Wu, H.; Eno, S.; Jinnai, K.; Maekawa, Y.; Saito, K.; Abe, A.; Williams, D. W.; Yamagata, N.; Kondo, S.; Tanimoto, H.
10.1101/2024.12.02.626512 — neuroscience — Posted on 2024-12-06
4170 MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia
Michmerhuizen, N. L.; Heikamp, E. B.; Iacobucci, I.; Umeda, M.; Arthur, B.; Mishra, V.; Di Giacomo, D.; Hiltenbrand, R.; Gao, Q.; Radko-Juettner, S.; Lott, J.; Martucci, C.; Subramanyam, V.; Hatton, C.; Baviskar, P.; Portola, P.; Claquin, A.; Chandra, B.; Baggett, D. W.; Khalighifar, A.; Huang, H.; Zhou, P.; Long, L.; Shi, H.; Sun, Y.; Papachristou, E. K.; Chilamakuri, C. S. R.; Vitorino, F. N. d. L.; Gongora, J. M.; Janke, L.; Kentsis, A.; D'Santos, C. S.; Garcia, B. A.; Kriwacki, R. W.; Chi, H.; Klco, J. M.; Armstrong, S. A.; Mullighan, C. G.
10.1101/2024.12.02.624182 — cancer biology — Posted on 2024-12-06
4171 Intragenomic variants of a putative effector drive early-stage infection in a broad host-range rust fungus
Degnan, R.; Sawyer, A.; Gardiner, D.; Luo, Z.; Frampton, R.; Schwessinger, B.; Mitter, N.; Carroll, B.; Smith, G.; McTaggart, A.; Shuey, L.
10.1101/2024.11.28.625939 — microbiology — Posted on 2024-12-06
4172 Targeted blocking of gene splicing can dysregulate intron-embedded microRNAs
Ali, M. H.; Kwiatkowski, W.; Kopec, P.; Nedunchezhian, N.; Pecherz, S.; Kowalewska, N.; Gnutti, B.; Finazzi, D.; Anbalagan, S.
10.1101/2024.12.04.626772 — molecular biology — Posted on 2024-12-05
4173 High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
Skowronek, D.; Pilz, R. A.; Saenko, V. V.; Mellinger, L.; Singer, D.; Ribback, S.; Weise, A.; Claassen, K.; Buttner, C.; Brockmann, E. M.; Hubner, C. A.; Aung, T.; Haerteis, S.; Bekeschus, S.; Ekici, A. B.; Felbor, U.; Rath, M.
10.1101/2024.12.04.626588 — molecular biology — Posted on 2024-12-05
4174 Cryo-EM reveals that cardiac IGLV6-derived AL fibrils can be polymorphic
Bassett, P. T.; Nguyen, B. A.; Singh, V.; Garrett, P.; Moresco, J. J.; Afrin, S.; Pekała, M.; Saelices, L.
10.1101/2024.12.04.626857 — molecular biology — Posted on 2024-12-05
4176 Isolation and Characterization of Antibodies Against VCAM-1 Reveals Putative Role for Ig-like Domains 2 and 3 in Cell-to-Cell Interaction
Perera, B.; Wu, Y.; Pickett, J. R.; Panagides, N.; Barretto, F. M.; Fercher, C.; Sester, D. P.; Jones, M. L.; Ta, H. T.; Zacchi, L. F.
10.1101/2024.12.03.626733 — molecular biology — Posted on 2024-12-05
4180 Scalable emulation of protein equilibrium ensembles with generative deep learning
Lewis, S.; Hempel, T.; Jimenez Luna, J.; Gastegger, M.; Xie, Y.; Foong, A. Y. K.; Garcia Satorras, V.; Abdin, O.; Veeling, B. S.; Zaporozhets, I.; Chen, Y.; Yang, S.; Schneuing, A.; Nigam, J.; Barbero, F.; Stimper, V.; Campbell, A.; Yim, J.; Lienen, M.; Shi, Y.; Zheng, S.; Schulz, H.; Munir, U.; Clementi, C.; Noe, F.
10.1101/2024.12.05.626885 — molecular biology — Posted on 2024-12-05
4181 Crackling Cloud: an event-driven, cloud-based CRISPR-Cas9 guide RNA design tool
Bradford, J.; Joy, D.; Winsen, M.; Meurant, N.; Wilkins, M.; Wilson, L.; Bauer, D.; Perrin, D.
10.1101/2024.12.04.626718 — bioinformatics — Posted on 2024-12-05
4182 Unusually Rapid Isomerization of Aspartic Acid in Tau
Shoff, T. A.; Van Orman, B.; Onwudiwe, V. C.; Genereux, J. C.; Julian, R. R.
10.1101/2024.12.04.626870 — biochemistry — Posted on 2024-12-05
4184 Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock-ins
Ming, Z.; Liu, F.; Moran, H. R.; Lalonde, R. L.; Adams, M.; Restrepo, N. K.; Joshi, P.; Ekker, S. C.; Clark, K. J.; Friedberg, I.; Yin, C.; Sumanas, S.; Mosimann, C.; Essner, J. J.; McGrail, M.
10.1101/2024.12.04.626907 — developmental biology — Posted on 2024-12-05
4185 Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus
Xiang, Q.; Wouters, C.; Chang, P.; Lu, Y.-N.; Liu, M.; Wang, H.; Yang, J.; Pekosz, A.; Zhang, Y.; Wang, J.
10.1101/2024.12.04.624804 — molecular biology — Posted on 2024-12-05
4188 Rad52 Acts as an Assembly Chaperone to Form and Stabilize Rad51 Filaments Through a Large C-Terminus 85-Residue Segment
Ma, E.; Lakhal, F.; Litsardaki, E.; Ruault, M.; Audin, M.; Levrier, N.; Navarro, E.; Garnier, M.; Maloisel, L.; Depagne, J.; Brocas, C.; Thureau, A.; Busso, D.; Veaute, X.; Guerois, R.; Taddei, A.; Ochsenbein, F.; Coic, E.
10.1101/2024.12.05.627070 — molecular biology — Posted on 2024-12-05
4191 High-Throughput Epigenetic Profiling Immunoassays for Accelerated Disease Research and Clinical Development
Van den Ackerveken, P.; Hannart, C.; Pamart, D.; Varsebroucq, R.; Wargnies, M.; Thiry, O.; Lurkin, M.; Vincent, S.; Chapelier, M.; Rommelaere, G.; Herzog, M.
10.1101/2024.12.05.626944 — molecular biology — Posted on 2024-12-05
4192 E-box independent chromatin recruitment turns MYOD into a transcriptional repressor
Nicoletti, C.; Massenet, J.; Pintado-Urbanc, A. P.; Connor, L. J.; Nicolau, M.; Sundar, S.; Xu, M.; Schmitt, A.; Zhang, W.; Fang, Z.; Chan, T. C. I.; Tapscott, S. J.; Cheung, T. H.; Simon, M. D.; Caputo, L.; Puri, P. L.
10.1101/2024.12.05.627024 — molecular biology — Posted on 2024-12-05
4193 Optimizing a Human Monoclonal Antibody for Better Neutralization of SARS-CoV-2
Wang, Q.; Guo, Y.; Casner, R. G.; Yu, J.; Nair, M. S.; Ho, J.; Reddem, E. R.; Tzang, C. C.; Huang, Y.; Shapiro, L.; Liu, L.; Ho, D. D.
10.1101/2024.12.04.626800 — microbiology — Posted on 2024-12-05
4194 Experimental Phage Evolution Results in Expanded Host Ranges Against MDR and XDR Klebsiella pneumoniae Isolates
Ghatbale, P.; Blanc, A.; Leonard, J.; Bates, M.; Garcia, A.; Nunes, D. D. G.; Hitchcock, N.; Shiach, J.; Bardaro, R.; Sah, G. P.; Ghose, C.; Whiteson, K.; Schooley, R.; White, R. A.; Cobian-Guemes, A. G.; Meyer, J. R.; Pride, D. T.
10.1101/2024.12.05.627030 — microbiology — Posted on 2024-12-05
4197 Metagenomic analysis of marsupial gut microbiomes provides a genetic basis for the low methane economy
Bowerman, K. L.; Lu, Y.; McRae, H.; Volmer, J. G.; Zaugg, J.; Pope, P. B.; Hugenholtz, P.; Greening, C.; Morrison, M.; Soo, R. M.; Evans, P. N.
10.1101/2024.12.04.626884 — microbiology — Posted on 2024-12-05
4199 DynaMAP: Dynamic Microbiome Abundance Profiling through high density optical mapping
Abakumov, S.; Ruppeka-Rupeika, E.; Chen, X.; Engelbrecht, M.; Mestdagh, I.; D'Huys, T.; Mlodzinska, A.; Leen, V.; Szymanek, A.; Badola, A.; Lukes, T.; Demuyser, T.; Hofkens, J.; Dedecker, P.; Bouwens, A.
10.1101/2024.12.05.626436 — microbiology — Posted on 2024-12-05
4200 Molecular cloning and host range analysis of three cytomegaloviruses from Mastomys natalensis
Staliunaite, L.; Puhach, O.; Ostermann, E.; Rosenke, K.; Nichols, J.; Oestereich, L.; Feldmann, H.; Davison, A. J.; Jarvis, M. A.; Brune, W.
10.1101/2024.12.05.626976 — microbiology — Posted on 2024-12-05
4201 Divergence in poxvirus-encoded E3-like proteins can dictate poxvirus activation of cellular necroptosis
Enow, J. A.; Munig, S.; Sample, M. L.; Speyer, G.; Chandrakanth, R.; Williams, J.; Bonner, J.; McFadden, G.; Jacobs, B.; Rahman, M. M.
10.1101/2024.12.05.627069 — microbiology — Posted on 2024-12-05
4202 The capsule and genetic background, rather than specific loci, strongly influence pneumococcal growth kinetics
Chaguza, C.; Arends, D. W.; Lo, S. W.; Putri, I. H.; York, A.; Lees, J. A.; Wyllie, A. L.; Weinberger, D. M.; Bentley, S. D.; de Jonge, M. I.; Cremers, A. J. H.
10.1101/2024.12.05.627025 — microbiology — Posted on 2024-12-05
4203 A TROP2/Claudin Program Mediates Immune Exclusion to Impede Checkpoint Blockade in Breast Cancer
Wu, B.; Thant, W.; Bitman, E.; Liu, T.; Liu, J.; Paschalis, E. I.; Xu, K. H.; Nieman, L. T.; Ting, D. T.; Thimmiah, N.; Sun, S.; Abelman, R. O.; Isakoff, S. J.; Spring, L. M.; Bardia, A.; Ellisen, L. W.
10.1101/2024.12.02.626446 — cancer biology — Posted on 2024-12-05
4205 Generating All-Atom Protein Structure from Sequence-Only Training Data
Lu, A. X.; Yan, W.; Robinson, S. A.; Yang, K. K.; Gligorijevic, V.; Cho, K.; Bonneau, R.; Abbeel, P.; Frey, N.
10.1101/2024.12.02.626353 — bioinformatics — Posted on 2024-12-05
4207 ERGA-BGE Reference Genome of Gluvia dorsalis: An Endemic Sun Spider from Iberian Arid Regions
Lozano-Fernandez, J.; Domenech, M.; Ibos, A.; Marcussen, T.; Struck, T. H.; Oomen, R.; Böhne, A.; Monteiro, R.; Aguilera, L.; Gut, M.; Camara Ferreira, F.; Cruz, F.; Gomez-Garrido, J.; Alioto, T. S.; De Panis, D.
10.1101/2024.12.02.626363 — genomics — Posted on 2024-12-05
4208 Cas9-based enrichment for targeted long-read metabarcoding
Nikolaeva-Reynolds, L.; Cammies, C.; Crichton, R.; Gorochowski, T. E.
10.1101/2024.12.02.626365 — genomics — Posted on 2024-12-05
4209 Uncovering Genes Essential in Domestication and Breeding of Sugar Beet
Dhiman, A. S.; Emrani, N.; Holtgrewe-Stukenbrock, E.; Varrelmann, M.; Jung, C.
10.1101/2024.12.02.626358 — genomics — Posted on 2024-12-05
4215 Designing a multi-serotype Dengue virus vaccine: an in silico approach to broad-spectrum immunity
Singh, A.; Glushchenko, O.; Ustiugova, A.; Alawi, K. M.; Korzinkin, M.; Zhavoronkov, A.; Castiglione, F.
10.1101/2024.12.02.626364 — immunology — Posted on 2024-12-05
4216 Characterization of HLA-DR immunopeptidome of bronchoalveolar lavage cells in patients with newly diagnosed rheumatoid arthritis and healthy current-smoker controls
Zohrer, B.; Vegvari, A.; Bonatti, M.; Kolosenko, I.; Wagner, N.; Checa, A.; Joshua, V.; Skold, C. M.; Lundberg, K.; Klareskog, L.; Malmstrom, V.; Wheelock, A. M.
10.1101/2024.12.02.626311 — immunology — Posted on 2024-12-05
4217 Octopamine signals coordinate the spatial pattern of presynaptic machineries in the Drosophila mushroom bodies
Wu, H.; Eno, S.; Jinnai, K.; Maekawa, Y.; Saito, K.; Abe, A.; Williams, D. W.; Yamagata, N.; Kondo, S.; Tanimoto, H.
10.1101/2024.12.02.626512 — neuroscience — Posted on 2024-12-05
4218 Synapse profiling of identified neurons in the Drosophila brain
Wu, H.; Maekawa, Y.; Eno, S.; Kondo, S.; Yamagata, N.; Tanimoto, H.
10.1101/2024.12.02.626511 — neuroscience — Posted on 2024-12-05
4220 Systematic analysis of immune cell motility leveraging Immunemap, an open intravital microscopy atlas
Pizzagalli, D. U.; Carrillo-Barbera, P.; Palladino, E.; Ceni, K.; Thelen, B.; Pulfer, A.; Moscatello, E.; Cabini, R. F.; Textor, J.; Wortel, I.; The immunemap project consortium, ; Krause, R.; Fernandez Gonzalez, S.
10.1101/2024.12.02.626343 — systems biology — Posted on 2024-12-05
4221 DoRIAT: A Bayesian Framework For Interpreting And Annotating Docking Runs.
Maniatis, C.; Ouaray, Z.; Xiao, K.; Dixon, T. P. E.; Snowden, J.; Teng, M. S.; Hurst, J.
10.1101/2024.12.02.626325 — systems biology — Posted on 2024-12-05
4223 Pharmacological inhibition of 11βhydroxysteroid dehydrogenase type 1 after myocardial infarction targets extracellular matrix processing and preserves cardiac function in a translational mini-pig model
Al Disi, S.; Ascione, R.; Khan, S.; Johnson, T. W.; Sammut, E.; Bruno, V. D.; Lopez, D. B.; James, C.-A.; Simpson, J. P.; Homer, N. Z. M.; Millar, M.; Singh, T.; Von Kriegsheim, A.; Mills, N. L.; Walker, B. R.; Andrew, R.; Webster, S. P.; Whittaker, A.; Freeman, A.; Gray, G. A.
10.1101/2024.12.02.626322 — pharmacology and toxicology — Posted on 2024-12-05
4225 Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes
Webster, A. P.; Makinen, N.; Mensah, N.; Castignani, C.; Larose Cadieux, E.; Shivdasani, R.; Singh, P.; Vaikkinen, H.; Dhami, P.; Ecker, S.; Brown, M.; Rimmer, B.; Henderson, S.; Herrero, J.; Suderman, M.; Yousefi, P. D.; Beck, S.; Van Loo, P.; Nakakura, E.; Thirlwell, C.
10.1101/2024.12.02.626017 — cancer biology — Posted on 2024-12-05
4226 RNA Binding of GAPDH Controls Transcript Stability and Protein Translation in Acute Myeloid Leukemia
Imig, J.; Shamloo, S.; Schlosshauer, J. L.; Tiwari, S.; Fischer, K. D.; Yohana Ghebrechristos, Y. G.; Kratzenberg, L.; Bejoy, A. M.; Aifantis, I.; Wang, E.
10.1101/2024.12.02.626357 — cancer biology — Posted on 2024-12-05
4227 Predicting antimicrobial class specificity of small molecules using machine learning
Gadiya, Y.; Genilloud, O.; Bilitewski, U.; Broenstrup, M.; von Berlin, L.; Attwood, M.; Gribbon, P.; Zaliani, A.
10.1101/2024.12.02.626313 — bioinformatics — Posted on 2024-12-05
4230 A robust benchmark for detecting low-frequency variants in the HG002 Genome In A Bottle NIST reference material.
Daniels, C.; Abdulkadir, A.; Cleveland, M. H.; McDaniel, J. H.; Jaspez, D.; Rubio-Rodriguez, L. A.; Munoz-Barrera, A.; Lorenzo-Salazar, J. M.; Flores, C.; Yoo, B.; Sahraeian, S. M. E.; Wang, Y.; Rossi, M.; Visvanath, A.; Murray, L.; Chen, W.-T.; Catreux, S.; Han, J.; Mehio, R.; Parnaby, G.; Carroll, A.; Chang, P.-C.; Shafin, K.; Cook, D. E.; Kolesnikov, A.; Brambrink, L.; Mootor, M. F. E.; Patel, Y.; Yamaguchi, T. N.; Boutros, P. C.; Sienkiewicz, K.; Foox, J.; Mason, C. E.; Lajoie, B.; Ruiz-Perez, C. A.; Kruglyak, S.; Zook, J. M.; Olson, N. D.
10.1101/2024.12.02.625685 — bioinformatics — Posted on 2024-12-05
4233 Implantable 3D printed multiplexed microtunnels for spinal cord injury treatment
Grebenyuk, S.; Medvediev, V.; Rybachuk, O.; Sheremet, Y.; Abdallah, I.; Ustymenko, V.; Pivneva, T.; Ranga, A.; Belan, P.; Voitenko, N.
10.1101/2024.12.02.626000 — bioengineering — Posted on 2024-12-05
4235 Molecular Insights into the Regulation of GNPTAB by TMEM251
Yang, X.; Doray, B.; Venkatarangan, V.; Jennings, B.; Henn, D.; Liang, J.; Zhao, H.; Zhang, W.; Zhang, B.; Yu, L.; Chen, L.; Kornfeld, K.; Li, M.
10.1101/2024.12.05.627003 — cell biology — Posted on 2024-12-05
4237 Convergence of autism proteins at the cilium
Kostyanovskaya, E.; Lasser, M. C.; Wang, B.; Schmidt, J.; Bader, E.; Buteo, C.; Arbelaez, J.; Sindledecker, A. R.; McCluskey, K. E.; Castillo, O.; Wang, S.; Dea, J.; Helde, K. A.; Graglia, J. M.; Brimble, E.; Kastner, D. B.; Ehrlich, A. T.; State, M. W.; Willsey, A. J.; Willsey, H. R.
10.1101/2024.12.05.626924 — cell biology — Posted on 2024-12-05
4238 Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles
Brancolini, A.; Bobbili, M. R.; Pultar, M.; Mazidi, Z.; Wieser, M.; Gamauf, J.; Roefs, M. T.; Corso, G.; Nivarthi, H.; Paredes, M. B. A.; Bettelheim, D.; Arcalis, E.; Dmitry, S.; Jacak, J.; Gerner, I.; Hackl, M.; Grillari, J.; Grillari-Voglauer, R.
10.1101/2024.12.05.626964 — cell biology — Posted on 2024-12-05
4239 GET3B interacts with the thylakoidal ALB3 and ALB4 insertases and is involved in the initial stages of chloroplast biogenesis
Bodensohn, U.; Duenschede, B.; Kuhlmann, C.; Kumari, K.; Ladig, R.; Grefen, C.; Schleiff, E.; Fernandez, D.; Schuenemann, D.
10.1101/2024.12.05.626995 — cell biology — Posted on 2024-12-05
4240 Analyzing Differences in Processing Nouns and Verbs in the Human Brain using Combined EEG and MEG Measurements
Koelbl, N.; Mueller-Voggel, N.; Rampp, S.; Kaltenhaeuser, M.; Tziridis, K.; Krauss, P.; Schilling, A.
10.1101/2024.12.04.626813 — neuroscience — Posted on 2024-12-05
4242 Cortex-wide characterization of decision-making neural dynamics during spatial navigation
Haley, S. P.; Surinach, D. A.; Nietz, A. K.; Carter, R. E.; Zecker, L. S.; Popa, L. S.; Kodandaramaiah, S. B.; Ebner, T. J.
10.1101/2024.10.23.619896 — neuroscience — Posted on 2024-12-05
4243 Harmonization of Diffusion MRI-based Structural Connectomes for Multi-site Studies
Shen, R. S.; Parker, D.; Chen, A. A.; Yerys, B. E.; Tunc, B.; Roberts, T. P. L.; Shinohara, R. T.; Verma, R.
10.1101/2024.10.08.617340 — neuroscience — Posted on 2024-12-05
4244 Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures
Converse, A.; Perry, M. J.; Dipali, S. S.; Isola, J. V.; Kelley, E. B.; Varberg, J. M.; Zelinski, M. B.; Gerton, J. L.; Stout, M. B.; Pritchard, M. T.; Duncan, F. E.
10.1101/2024.12.03.626649 — cell biology — Posted on 2024-12-05
4246 Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer
Tavakoli, N.; Fong, E. J.; Coleman, A.; Huang, Y.-K.; Bigger, M.; Doche, M. E.; Kim, S.; Lenz, H.-J.; Graham, N. A.; Macklin, P.; Finley, S. D.; Mumenthaler, S. A.
10.1101/2024.05.24.595756 — systems biology — Posted on 2024-12-05
4249 SynapseNet: Deep Learning for Automatic Synapse Reconstruction
Muth, S.; Moschref, F.; Freckmann, L.; Mutschall, S.; Garcia-Plaza, I.; Bahr, J. N.; Petrovic, A.; Thao Do, T.; Schwarze, V.; Archit, A.; Weyand, K.; Michanski, S.; Maus, L.; Imig, C.; Brose, N.; Wichmann, C.; Fernandez-Busnadiego, R.; Moser, T.; Rizzoli, S. O.; Cooper, B. H.; Pape, C.
10.1101/2024.12.02.626387 — bioinformatics — Posted on 2024-12-05
4251 HIV-1 protein coding sequences are present in relevant bacteria
Pelaez-Prestel, H. F.; Mozas-Gutierrez, J.; Lafuente, E. M.; Reche, P. A.
10.1101/2024.12.04.626764 — microbiology — Posted on 2024-12-05
4253 CD226+ adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism.
Gallerand, A.; Caillot, Z.; Terekhova, M.; Castiglione, A.; Leporati, L.; Giacchero, M.; Pilot, T.; Chang, M.; Dolfi, B.; Zair, F. N.; Goes, E.; Bennetot, A.; Mlamla, Z.; Mass, E.; Ginhoux, F.; Voehringer, D.; Mack, M.; Dombrowicz, D.; Williams, J. W.; Masson, D.; Artyomov, M. N.; Bertola, A.; IVANOV, S.
10.1101/2024.12.03.626330 — immunology — Posted on 2024-12-05
4255 Non-shivering thermogenesis is intact upon brown-adipocyte specific loss of ATGL and HSL due to white adipose tissue browning
Manandhar, Y.; Pirchheim, A.; Hofer, P.; Vujic, N.; Kolb, D.; Hoefler, G.; Kratky, D.; Schweiger, M.; Taschler, U.; Zimmermann, R.; Zechner, R.; Schreiber, R.
10.1101/2024.12.04.626093 — physiology — Posted on 2024-12-05
4257 Phenotyping the hidden half: Combining UAV phenotyping and machine learning to predict barley root traits in the field
Alahmad, S.; Smith, D.; Katsikis, C.; Aldiss, Z.; Van Der Meer, S.; Meijer, L.; Chenu, K.; Chapman, S. C.; Potgieter, A.; Wasson, A. P.; Baraibar, S.; Godoy, J.; Moody, D.; Robinson, H.; Hickey, L.
10.1101/2024.12.02.626299 — physiology — Posted on 2024-12-05
4258 Study on the mechanism of action of the Pt(IV) complex with lonidamine ligands by ultrafast chemical proteomics
Imaikina, E. A..; Fedorov, I. I.; Emekeeva, D. D.; Kazakova, E. M.; Garibova, L. A.; Ivanov, M. V.; Shutkov, I. A.; Nazarov, A. A.; Gorshkov, M. V.; Tarasova, I.
10.1101/2024.12.02.626306 — pharmacology and toxicology — Posted on 2024-12-05
4259 Downregulation of Gankyrin/PSMD10 affects cancer cell growth and proliferation in glioblastoma: in vitro and in vivo study
Travnikova, D.; Shashkovskaya, V.; Kordyukova, M.; Nosova, I.; Kudryashova, O.; Zatsepin, T.; Belousov, V.; Abakumova, T.
10.1101/2024.12.02.626412 — cancer biology — Posted on 2024-12-05
4260 Circular RNA - circCLIP2 is predominantly expressed in GSC niche and enhances glioblastoma aggressiveness via EMT and ECM signaling
Misiorek, J. O.; Zarebska, Z.; Kuczynski, K.; Latowska-Lysiak, J.; Grabowska, A.; Glodowicz, P.; Sajek, M. P.; Karlik, A.; Wronka, D.; Barciszewska, A. M.; Przybyl, L.; Rolle, K.
10.1101/2024.12.01.626287 — cancer biology — Posted on 2024-12-05
4261 MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia
Mullighan, C. G.; Michmerhuizen, N. L.; Heikamp, E. B.; Iacobucci, I.; Umeda, M.; Arthur, B.; Mishra, V.; Di Giacomo, D.; Hiltenbrand, R.; Gao, Q.; Radko-Juettner, S.; Lott, J.; Martucci, C.; Subramanyam, V.; Hatton, C.; Baviskar, P.; Portola, P.; Claquin, A.; Chandra, B.; Baggett, D. W.; Khalighifar, A.; Huang, H.; Zhou, P.; Long, L.; Shi, H.; Sun, Y.; Papachristou, E. K.; Chilamakuri, C. S. R.; Vitorino, F. N. d. L.; Gongora, J. M.; Janke, L.; Kentsis, A.; D'Santos, C. S.; Garcia, B. A.; Kriwacki, R. W.; Chi, H.; Klco, J. M.; Armstrong, S. A.
10.1101/2024.12.02.624182 — cancer biology — Posted on 2024-12-05
4262 Opposing lineage specifiers induce a pro-tumor hybrid-identity state in lung adenocarcinoma
Fort, G.; Arnold, H.; Camolotto, S.; Tariq, R.; Waters, A.; O'Toole, K. T.; Snyder, E. L.
10.1101/2024.12.02.626384 — cancer biology — Posted on 2024-12-05
4263 Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning
Estevam, G. O.; Linossi, E. M.; Rao, J.; Macdonald, C. B.; Ravikumar, A.; Chrispens, K. M.; Capra, J. A.; Coyote-Maestas, W.; Pimentel, H.; Collisson, E. A.; Jura, N.; Fraser, J. S.
10.1101/2024.07.16.603579 — cancer biology — Posted on 2024-12-05
4264 Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment
Waitman, K. B.; Martin, H.-J.; Carlos, J. A. E. G.; Braga, R. C.; Souza, V. A. M.; Melo-Filho, C. C.; Hilscher, S.; Toledo, M. F. Z. J.; Tavares, M. T.; Costa-Lotufo, L. V.; Machado-Neto, J. A.; Schutkowski, M.; Sippl, W.; Kronenberger, T.; Alves, V. M.; Parise-Filho, R.; Muratov, E. N.
10.1101/2024.11.30.626092 — cancer biology — Posted on 2024-12-05
4265 Frustration in the Protein-Protein interface Plays a Central Role in the Cooperativity of PROTAC Ternary Complexes
Ma, N.; Bhattacharya, S.; Muk, S.; Jandova, Z.; Schmalhorst, P. S.; Ghosh, S.; Le, K. M.; Diers, E.; Trainor, N.; Farnaby, W.; Roy, M. J.; Kofink, C.; Greb, P.; Weinstabl, H.; Ciulli, A.; Bader, G.; Sanker, K.; Bergner, A.; Vaidehi, N.
10.1101/2024.12.03.626645 — biophysics — Posted on 2024-12-05
4268 Remission spectroscopy resolves the mode of action of bedaquiline within living mycobacteria
Harrison, S. H.; Walters, R. C.; Cheung, C.-Y.; Springett, R. J.; Cook, G. M.; Osman, M. M.; Blaza, J. N.
10.1101/2024.12.03.626386 — biophysics — Posted on 2024-12-05
4275 Time is encoded by methylation changes at clustered CpG sites
Ochana, B.-L.; Nudelman, D.; Cohen, D.; Peretz, A.; Piyanzin, S.; Gal, O.; Horn, A.; Loyfer, N.; Varshavsky, M.; Raisch, R.; Shapiro, I.; Friedlander, Y.; Glaser, B.; Hochner, H.; Dor, Y.; Kaplan, T.; Shemer, R.
10.1101/2024.12.03.626674 — genomics — Posted on 2024-12-05
4276 Prediabetes Phenotype Clusters in the Diabetes Prevention Program Study
Stroebel, B. M.; Gadgil, M.; Lewis, K.; Longoria, K.; Zhang, L.; Flowers, E.
10.1101/2024.12.02.626435 — genomics — Posted on 2024-12-05
4277 Draft genome and transcriptomic sequence data of three invasive insect species
Lombaert, E.; Klopp, C.; Blin, A.; Annonay, G.; Iampietro, C.; Lluch, J.; Sallaberry, M.; Valiere, S.; Poloni, R.; Joron, M.
10.1101/2024.12.02.626401 — genomics — Posted on 2024-12-05
4278 Thermosensory neurons control genetic inheritance through regulation of germline transposons
Szanto, P.; Meyer, D. H.; Teichman, G.; Perez-Llanos, F.; Rickert, D.; Koehrer, K.; Rechavi, O.; Schumacher, B.
10.1101/2024.12.02.626368 — genetics — Posted on 2024-12-05
4280 Modelling Eurasian lynx populations in Western Europe: What prospects for the next 50 years?
Bauduin, s.; Germain, E.; Zimmermann, F.; Idelberger, S.; Herdtfelder, M.; Heurich, M.; Kramer-Schadt, S.; Duchamp, C.; Drouet-Hoguet, N.; Morand, A.; Blanc, L.; Charbonnel, A.; Gimenez, O.
10.1101/2021.10.22.465393 — ecology — Posted on 2024-12-05
4281 A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
Zeeshan, M.; Blatov, I.; Yanase, R.; Ferguson, D. J. P.; Pashley, S. L.; Chahine, Z.; Botte, Y. Y.; Mishra, A.; Marche, B.; Bhanvadia, S.; Hair, M.; Batra, S.; Markus, R.; Brady, D.; Bottrill, A.; vaughan, s.; Botte, C. Y.; Le Roch, K. G.; Holder, A. A.; Tromer, E. C.; Tewari, R.
10.1101/2024.12.04.625416 — cell biology — Posted on 2024-12-05
4282 Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex
Duncan, J. D.; Pathak, M.; King, B. J.; Bamber, H.; Radford, P.; Dey, J.; Richardson, C.; Astbury, S.; McClure, P.; Ball, J. K.; Urbanowicz, R. A.; Tarr, A. W.
10.1101/2024.12.05.626977 — microbiology — Posted on 2024-12-05
4283 Human-immune-system humanized-DRAGA mice are a valuable model to study novel immunotherapies for HIV-1
Pumtang-on, P.; Goodarzi, N.; Davey, B. C.; Sevcik, E. N.; Coleman-Fuller, N.; Vezys, V.; Rao, M.; Pampusch, M. S.; Rendahl, A. K.; Casares, S. A.; Skinner, P. J.
10.1101/2024.12.02.626442 — immunology — Posted on 2024-12-05
4285 Abnormal eNK cells contribute to endometrial fibrosis in intrauterine adhesions patients
Zhou, Z.; Weng, Q.; Liu, D.; Yao, S.; Zou, X.; Wang, H.; Zhou, Z.; Zhu, H.; Zhang, X.; Chen, L.; Zhang, X.; Zhao, G.; Hu, Y.
10.1101/2024.12.01.626271 — immunology — Posted on 2024-12-05
4289 Conservation of function without conservation of amino acid sequence in intrinsically disordered transcriptional activation domains
LeBlanc, C. J.; Stefani, J.; Soriano, M.; Lam, A.; Zintel, M. A.; Kotha, S. R.; Chase, E.; Pimentel-Solorio, G.; Vunnum, A.; Flug, K. L.; Fultineer, A. T.; Hummel, N.; Staller, M. V.
10.1101/2024.12.03.626510 — systems biology — Posted on 2024-12-05
4290 The intrinsic dimension of gene expression during cell differentiation
Biondo, M.; Cirone, N.; Valle, F.; Lazzardi, S.; Caselle, M.; Osella, M.
10.1101/2024.08.02.606382 — systems biology — Posted on 2024-12-05
4292 A single-cell atlas of transcriptome changes in the intestinal epithelium at the suckling-to-weaning transition
Malonga, T.; Knudsen, C.; Lhuillier, E.; Aymard, P.; Jones, E.; Lencina, C.; Despeyroux, M.; Riant, E.; Cabau, C.; Ivy, A.; Loving, C. L.; Vialaneix, N.; Beaumont, M.
10.1101/2024.12.02.626361 — physiology — Posted on 2024-12-05
4293 Yo-yo dieting deregulates feeding behavior in mice via the induction of durable gut dysbiosis
Fouesnard, M.; Salin, A.; Ribes, S.; Monnoye, M.; Champeil-Potokar, G.; Hjeij, M.-S.; Randuineau, G.; Le Gleau, L.; Ben Fradj, S.; Philippe, C.; Benani, A.; Denis, I.; Douard, V.; Boudry, G.
10.1101/2024.12.02.625705 — physiology — Posted on 2024-12-05
4295 Cannabidiol promotes apoptosis and downregulation of oncogenic factors
Greenwood, A. L.; Yamamoto, T.; Joshi, M. G.; Hutchison, K.; Bitler, B. G.
10.1101/2024.11.30.626177 — cancer biology — Posted on 2024-12-05
4296 Patient-derived HCC cells recapitulating the transcriptomic landscape of primary HCV-related liver cancer
Kah, J.; Staffeldt, L.; Volz, T.; Schulze, K.; Roevenstrunk, G.; Goebel, M.; Peine, S.; Dandri, M.; Lueth, S.
10.1101/2024.12.01.626251 — cancer biology — Posted on 2024-12-05
4297 Systems biology-enabled targeting of NF-κB and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL.
Vareli, A.; Narayanan, H. V.; Clark, H.; Jayawant, E.; Zhou, H.; Liu, Y.; Stott, L.; Simoes, F.; Hoffmann, A.; Pepper, A.; Pepper, C.; Mitchell, S.
10.1101/2024.11.30.626166 — cancer biology — Posted on 2024-12-05
4298 OST Catalytic Subunit Redundancy Enables Therapeutic Targeting of N-Glycosylation
Baro, M.; Lee, H.; Kelley, V.; Lou, R.; Phoomak, C.; Politi, K.; Zeiss, C. J.; Van Zandt, M.; Contessa, J. N.
10.1101/2024.12.03.626593 — cancer biology — Posted on 2024-12-05
4299 Unraveling the Phenotype of Dormant Metastases Controlled by the Immune System
Chamorro, V.; Algarra, I.; Sanz, V.; Pulido, M.; Romero, I.; Chico, E.; Millan, M.; Escano-Maestre, M.; Linares, i.; Garcia-Lora, A. M.
10.1101/2024.12.02.626440 — cancer biology — Posted on 2024-12-05
4300 IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma
Karakousi, T.; Cristaldi, V.; Lopes de Oliveira, M. L.; Medeiros Geraldo, L. H.; Gonzalez-Robles, T.; da Silva, G.; Breazeale, A. P.; Encarnacion Rosado, J.; Pozniak, J.; Kimmelman, A.; Ruggles, K.; Marine, J. C.; Chandel, N. S.; Lund, A. W.
10.1101/2024.12.02.626426 — cancer biology — Posted on 2024-12-05
4301 Target cell tension regulates macrophage trogocytosis
Cornell, C. E.; Chorlay, A.; Krishnamurthy, D.; Martin, N. R.; Baldauf, L.; Fletcher, D. A.
10.1101/2024.12.02.626490 — biophysics — Posted on 2024-12-05
4303 Voltage Gated Calcium Channel Dysregulation May Contribute to Neurological Symptoms in Calmodulinopathies
Hussey, J. W.; DeMarco, E.; DiSilvestre, D.; Brohus, M.; Busuioc, A.-O.; Iversen, E. D.; Jensen, H. H.; Nyegaard, M.; Overgaard, M. T.; Ben-Johny, M.; Dick, I. E.
10.1101/2024.12.02.626503 — biophysics — Posted on 2024-12-05
4308 Accurate and General DNA Representations Emerge from Genome Foundation Models at Scale
Ellington, C. N.; Sun, N.; Ho, N.; Tao, T.; Mahbub, S.; Li, D.; Zhuang, Y.; Wang, H.; Song, L.; Xing, E. P.
10.1101/2024.12.01.625444 — bioinformatics — Posted on 2024-12-05
4309 A Novel Efficient Algorithm for Common Variants Genotyping from Low-Coverage Sequencing Data
Zhang, S.; Xiao, K.; He, X.; Hao, M.; Ma, Y.; Tian, Y.; Jin, L.; Li, Y.; Wang, J.; Wang, Y.
10.1101/2024.12.01.626280 — bioinformatics — Posted on 2024-12-05
4310 ProtSpace: a tool for visualizing protein space
Senoner, T.; Olenyi, T.; Heinzinger, M.; Spannagl, A.; Bouras, G.; Rost, B.; Koludarov, I.
10.1101/2024.11.30.626168 — bioinformatics — Posted on 2024-12-05
4312 Balancing Locality and Reconstruction in Protein Structure Tokenizer
Meynard-Piganeau, B.; Zhang, J.; Gong, J.; Cheng, X.; Luo, Y.; Ly, H.; Song, L.; Xing, E. P.
10.1101/2024.12.02.626366 — bioinformatics — Posted on 2024-12-05
4313 A CRISPR/SpCas9M-reporting system for efficient and rapid genome editing in Caulobacter crescentus
Sun, J.; Yu, X.; Tang, G.; Chen, M.; Zheng, Y.; Hu, Y.; Li, Q.; Li, X.; Li, N.; Li, Z.; Li, Y.; Lu, N.; Tan, W.; Yang, Y.; Zeng, X.; Zhao, G.; Wang, H.; Dai, L.; Zhao, G.-P.; Ai, L.; Zhao, W.
10.1101/2024.12.02.626314 — bioengineering — Posted on 2024-12-05
4315 Genomes of Poaceae sisters reveal key metabolic innovations preceding the emergence of grasses
Takeda-Kimura, Y.; Moore, B.; Holden, S.; Deb, S. K.; Barrett, M.; Lorence, D.; de Oliveira, M. V. V.; Grimwood, J.; Williams, M.; Boston, L. B.; Jenkins, J. W.; Plott, C.; Shu, S.; Barry, K. W.; Goodstein, D. M.; Schmutz, J.; Moscou, M. J.; McKain, M. R.; Leebens-Mack, J. H.; Maeda, H. A.
10.1101/2024.11.06.622220 — genomics — Posted on 2024-12-05
4316 A lineage-resolved multimodal single-cell atlas reveals the genomic dynamics of early C. elegans development
van der Burght, S. N.; Carelli, F. N.; Appert, A.; Dong, Y.; Hill, M.; Buttress, T.; Butler, R.; Ahringer, J.
10.1101/2024.12.02.626321 — genomics — Posted on 2024-12-05
4317 Dynamic Control of Argonautes by a Rapidly Evolving Immunological Switch
Ewe, C. K.; Teichman, G.; Knott, M. M.; Anava, S.; Gingold, H.; Bardan Sarmiento, M.; Troemel, E.; Rechavi, O.
10.1101/2024.11.30.626165 — genetics — Posted on 2024-12-05
4319 Enhanced methods for genetic assays in Drosophila cells
Wang, Y.; Lee, J. Y.; Housden, A.; Hottinger, E.; Housden, B. E.
10.1101/2024.12.01.626214 — genetics — Posted on 2024-12-05
4321 Essential genes encoded by the mating-type locus of the human fungal pathogen Cryptococcus neoformans
Bian, Z.; Xu, Z.; Peer, A.; Choi, Y.; Priest, S. J.; Akritidou, K.; Dasgupta, A.; Dahlmann, T.; Kück, U.; Nowrousian, M.; Sachs, M.; Sun, S.; Heitman, J.
10.1101/2024.12.02.626420 — genetics — Posted on 2024-12-05
4322 Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance
Teichman, G.; Sela, M.; Ewe, C. K.; Rieger, I.; Anava, S.; Mor, Y.; Szanto, P.; Meyer, D. H.; Doron, H.; Shachar, O.; Pechuk, V.; Gingold, H.; Oren-Suissa, M.; McGee, M.; Shapira, M.; Schumacher, B.; Rechavi, O.
10.1101/2024.12.02.626416 — genetics — Posted on 2024-12-05
4325 The role of transposon activity in shaping cis-regulatory element evolution after whole genome duplication
Monsen, O.; Gronvold, L.; Datsomor, A.; Harvey, T. N.; Kijas, J.; Suh, A. S.-J.; Hvidsten, T. R.; Sandve, S. R.
10.1101/2024.01.02.573861 — evolutionary biology — Posted on 2024-12-05
4328 Monitoring for fisheries or for fish? Declines in monitoring of salmon spawners continue despite a conservation crisis
Atkinson, E. M.; Carturan, B. S.; Atkinson, C. P.; Bateman, A. W.; Connors, K.; Hertz, E.; Peacock, S. J.
10.1101/2024.12.01.626233 — ecology — Posted on 2024-12-05
4329 Harmonising digitised herbarium data to enhance biodiversity knowledge: creating an updated checklist for the flora of Greenland.
Whitley, B. S.; Abermann, J.; Alsos, I. G.; Biersma, E. M.; Gardman, V.; Hoye, T. T.; Jones, L.; Khelidj, N. M.; Li, Z.; Losapio, G.; Pape, T.; Raundrup, K.; Schmitz, P.; Silva, T.; Wirta, H.; Roslin, T.; Ahlstrand, N. I.; de Vere, N.
10.1101/2024.12.01.626242 — ecology — Posted on 2024-12-05
4330 Calcium transfer from the ER to other organelles for optimal signaling in Toxoplasma gondii.
Li, Z.-H.; Asady, B.; Chang, L.; Hortua Triana, M. A.; Li, C.; Coppens, I.; Moreno, S. N.
10.1101/2024.08.15.608087 — cell biology — Posted on 2024-12-05
4332 RNA-binding proteins control the G2-M checkpoint of the germinal centre B cell
Salerno, F.; Whale, A.; Matheson, L. S.; Foster, W.; Stammers, M.; Bell, S. E.; Hidson, D. J.; Linterman, M. A.; Houseley, J. A.; Turner, M.
10.1101/2024.12.01.626220 — immunology — Posted on 2024-12-05
4337 Investigating the consequences of chronic short sleep for metabolism and survival of oxidative stress
Tener, S. J.; Kim, C. E.; Lee, J.; Oraedu, K.; Gatto, J. A.; Chang, T. Y.; Lam, C.; Schanta, R.; Jankowski, M. S.; Park, S.; Hurley, J. M.; Ulgherait, M.; Canman, J. C.; Ja, W.; Collins, D. B.; Shirasu-Hiza, M.
10.1101/2024.12.01.626207 — physiology — Posted on 2024-12-05
4340 Microvascular pulsatility of the ageing brain and confounding effects of anaesthesia
Skott, M. V.; Melnikova, E.; Gutierrez-Jimenez, E.; Matchkov, V. V.; Ostergaard, L.; Postnov, D. D.
10.1101/2024.12.01.626169 — physiology — Posted on 2024-12-05
4343 Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer
Zhang, Y.; Ling, L.; Maganti, S.; Hope, J. L.; Galapate, C. M.; Carrette, F.; Duong-Polk, K.; Bagchi, A.; Scott, D. A.; Lowy, A. M.; Bradley, L. M.; Commisso, C.
10.1101/2024.11.29.625709 — cancer biology — Posted on 2024-12-05
4345 Spatial single cell transcriptomic analysis of a novel DICER1 Syndrome GEMM informs the cellular origin and developmental hierarchy of associated sarcomas
Kommoss, F. K.; Zhang, J.; Lynch, B. J.; Chen, S.; Senz, J.; Moscovitz, Y.; Hill, L. A.; Scott, W.; Bush, J.; Chen, K. S.; von Deimling, A.; Foulkes, W. D.; Morin, G. B.; Underhill, T. M.; Wang, Y.; Huntsman, D. G.
10.1101/2024.11.30.624592 — cancer biology — Posted on 2024-12-05
4355 Spherical Phenotype Clustering
Nightingale, L.; Tuersley, J.; Cairoli, A.; Howes, J.; Shand, C.; Powell, A.; Green, D.; Strange, A.; Warchal, S.; Howell, M.
10.1101/2024.04.19.590313 — bioinformatics — Posted on 2024-12-05
4356 Local Haplotype Classifiers enable Efficient, Flexible, and Secure Genotype Imputation and Downstream Analyses
Cheema, M. N.; Nazir, A.; Moon, J.; Oh, Y.; Naseri, A.; Zhi, D.; Jiang, X.; Kim, M.; Harmanci, A. O.
10.1101/2024.12.01.626205 — bioinformatics — Posted on 2024-12-05
4365 Early 2022 breakthrough infection sera from India target the conserved cryptic class 5 epitope to counteract immune escape by SARS-CoV-2 variants
Das Jana, I.; Kanjo, K.; Roy, S.; Bhasin, M.; Bhattacharya, S.; Banerjee, I.; Jana, S.; Chatterjee, A.; Chakraborty, A.; Chakraborty, S.; Mukherjee, B.; Varadarajan, R.; Mondal, A.
10.1101/2024.07.08.602485 — molecular biology — Posted on 2024-12-05
4371 Deep-tissue spatial omics: imaging whole-embryo transcriptomics and subcellular structures at high spatial resolution
Gandin, V.; Kim, J.; Yang, L.-Z.; Lian, Y.; Kawase, T.; Hu, A.; Rokicki, K.; Fleishman, G.; Tillberg, P.; Aguilera Castrejon, A.; Stringer, C.; Preibisch, S.; Liu, Z. J.
10.1101/2024.05.17.594641 — developmental biology — Posted on 2024-12-05
4372 EOR-1/PLZF-regulated WAH-1/AIF sequentially promotes early and late stages of non-apoptotic corpse removal
Rather, N.; Williams, M.; Elkhalil, A.; Sharmin, R.; Juanez, K.; Clark, G.; Shaham, S.; Ghose, P.
10.1101/2024.12.04.626465 — cell biology — Posted on 2024-12-05
4373 Boosting of CAR-T cells with rhabdovirus is limited by type I interferon and rapid contraction
Burchett, R.; Morris, C. G.; Ishak, M.; Cummings, D.; Baker, C. L.; Marius, R.; Kazdhan, N.; Silvestri, C. M.; Bell, J. C.; Lichty, B. D.; Walsh, S. R.; Wan, Y.; Hammill, J. A.; Bramson, J. L.
10.1101/2024.11.29.626103 — immunology — Posted on 2024-12-05
4378 Low-input soil management increases yield and decreases CO2-emissions but aggravates risk of nitrate leaching and diseases in winter wheat cropping systems under climate change
Michel, J.; Leemans, V.; Weinmann, M.; Balanzategui-Guijarro, I.; Bin, J.; Biver, S.; Blum, A.; Borger, R.; Him, S. L.; Kirbas, G.; Le Gouis, J.; Moya-Larano, J.; Persyn, M.; Pierreux, J.; Quenon, A.; Sanchez-Moreno, S.; Symanczik, S.; Vanden Brande, F.; Van Der Straeten, D.; Wagner, M.; Waibel, M.; Xayphrarath, A.; Vanderschuren, H.; Thonar, C.; Delaplace, P.
10.1101/2024.11.30.626142 — ecology — Posted on 2024-12-05
4381 Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats
Mardinoglu, A.; Yang, H.; Zhang, C.; Kim, W.; Shi, M.; Kiliclioglu, M.; Bayram, C.; Bolar, I.; Tozlu, O. O.; Baba, C.; Yuksel, N.; Yildirim, S.; Iqbal, S.; Sebhaoui, J.; Hacımuftuoglu, A.; Uhlen, M.; Boren, J.; Turkez, H.
10.1101/2024.04.22.590583 — bioinformatics — Posted on 2024-12-05
4382 CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network of Postnatal Atrial Cardiomyocytes
Sweat, M. E.; Shi, W.; Keating, E. M.; Ponek, A.; Li, J.; Ma, Q.; Park, C.; Trembley, M. A.; Wang, Y.; Bezzerides, V. J.; Conlon, F. J.; Pu, W. T.
10.1101/2024.12.04.626894 — genomics — Posted on 2024-12-05
4384 The essential host genome for Cryptosporidium intracellular survival exposes metabolic dependencies that can be leveraged for treatment
Marzook, N. B.; Song, O.-R.; Baumgärtel, L.; Bernitz, N.; Mkandawire, T. T.; Watson, L. C.; Nunes, V.; Warchal, S.; MacRae, J. I.; Howell, M.; Sateriale, A.
10.1101/2024.12.04.626561 — cell biology — Posted on 2024-12-05
4385 Deferoxamine as adjunct therapeutics for tuberculosis
Kaushik, S. R.; Yadav, N.; Gupta, A.; Sahu, S.; Bhalla, N.; Dagar, P.; Mohapatra, A. K.; Sarangi, A.; Sharma, T.; Biswal, B.; Pandey, A. K.; Nanda, R.
10.1101/2023.06.02.543389 — microbiology — Posted on 2024-12-05
4387 4-Methyllumifrone (4-MU) can improve learning and memory after cerebral ischemia/reperfusion injury in rats
Tamouk, S.; Mirshekari Jahangiri, H.; Kashafi Jahromi, E.; Hamblin, M. R.; Aboutaleb, N.; Ramezani, F.
10.1101/2024.11.29.626098 — neuroscience — Posted on 2024-12-05
4389 Gut MicrobiotAware: how much do we know about gut microbiota? An international questionnaire.
Garcia-Gutierrez, E.; Arbulu, S.; Oliver, C.; Kumar, S.; Dam, S. A.; Jakobi, B.; Pennone, V.; Hoffmann Sarda, F. A.; Mukherjee, A.; Cotter, P. D.
10.1101/2024.12.04.626811 — scientific communication and education — Posted on 2024-12-05
4390 AER-270 and TGN-020 are not aquaporin-4 water channel blockers
Unger, L.; Wagner, K.; Steffen, J. H.; Wind, M. L.; Al-Jubair, T.; Zou, H.; Clarke-Bland, C.; Murray, R.; Lundstrom, S.; Gaetani, M.; Ayub, H.; Poyner, D.; Wheatley, M.; Gourdon, P.; Yool, A. J.; Tornroth-Horsefield, S.; Bill, R. M.; Salman, M. M.; Kitchen, P.
10.1101/2024.12.04.625365 — biophysics — Posted on 2024-12-05
4392 CGC1, a new reference genome for Caenorhabditis elegans
Ichikawa, K.; Shoura, M. J.; Artiles, K. L.; Jeong, D.-E.; Owa, C.; Kobayashi, H.; Suzuki, Y.; Kanamori, M.; Toyoshima, Y.; Iino, Y.; Rougvie, A. E.; Wahba, L.; Fire, A. Z.; Schwarz, E. M.; Morishita, S.
10.1101/2024.12.04.626850 — genomics — Posted on 2024-12-05
4393 The Effects of Heat Stress on the Ovary, Follicles and Oocytes: A Systematic Review
Zhou, L. T.; Gokyer, D. T.; Madkins, K.; Beestrum, M.; Horton, D. E.; Duncan, F.; Babayev, E.
10.1101/2024.12.04.626831 — developmental biology — Posted on 2024-12-05
4394 Inhibition of RhoA-mediated secretory autophagy in megakaryocytes mitigates myelofibrosis in mice
Becker, I. C.; Barrachina, M. N.; Lykins, J.; Camacho, V.; Stone, A. P.; Chua, B. A.; Signer, R. A.; Machlus, K. R.; Whiteheart, S. W.; Roweth, H. G.; Italiano, J. E.
10.1101/2024.12.04.626665 — cell biology — Posted on 2024-12-05
4397 Convergence of autism proteins at the cilium
Kostyanovskaya, E.; Lasser, M. C.; Wang, B.; Schmidt, J.; Bader, E.; Buteo, C.; Arbelaez, J.; Sindledecker, A. R.; McCluskey, K. E.; Castillo, O.; Wang, S.; Dea, J.; Helde, K. A.; Graglia, J. M.; Brimble, E.; Kastner, D. B.; Ehrlich, A. T.; Willsey, A. J.; State, M. W.; Willsey, H. R.
10.1101/2024.12.05.626924 — cell biology — Posted on 2024-12-05
4398 Generation of iPSC line ERCi004-A from human dermal fibroblasts of a patient with maturity-onset diabetes of the young type 3 caused by a heterozygous mutation in the HNF1A gene
Bastrich, A.; Antonov, D.; Podzhilkova, A.; Petrova, D. A.; Pylina, S. V.; Laptev, D. N.; Sechko, E. A.; Kuznetsov, S. N.; Vetchinkina, E. A.; Mokrysheva, N. G.
10.1101/2024.12.04.626820 — cell biology — Posted on 2024-12-05
4399 Extracellular HDAC6 ZnF UBP domain enhances podosome-mediated neuronal migration
Qureshi, T.; Desale, S. E.; Sonawane, S. K.; Balmik, A. A.; Chidambaram, H.; Chinnathambi, S.
10.1101/2024.12.04.626746 — cell biology — Posted on 2024-12-05
4400 Non canonical Sun1-Allan complex orchestrates nuclear envelope remodelling and Basal Body/MTOC Segregation during rapid mitosis in Plasmodium
Zeeshan, M.; Blatov, I.; Yanase, R.; Ferguson, D. J. P.; Pashley, S. L.; Chahine, Z.; Botte, Y. Y.; Mishra, A.; Marche, B.; Bhanvadia, S.; Hair, M.; Batra, S.; Markus, R.; Brady, D.; Bottrill, A.; vaughan, s.; Botte, C. Y.; Le Roch, K. G.; Holder, A. A.; Tromer, E. C.; Tewari, R.
10.1101/2024.12.04.625416 — cell biology — Posted on 2024-12-05
4401 Generation of an induced pluripotent stem cell line ERCi003-A derived from a patient with maturity-onset diabetes of the young type 10 caused by a heterozygous INS mutation
Bastrich, A.; Antonov, D.; Podzhilkova, A.; Petrova, D. A.; Pylina, S. V.; Laptev, D. N.; Sechko, E. A.; Kuznetsov, S. N.; Vetchinkina, E. A.; Mokrysheva, N. G.
10.1101/2024.12.04.626760 — cell biology — Posted on 2024-12-05
4402 Glucose-Sensing ChREBP Protein in the Pathogenesis of Diabetic Retinopathy
Starr, C. R.; Zhylkibayev, A.; Gorbatyuk, O.; Nuotio-Antar, A. M.; Mobley, J.; Grant, M. B.; Gorbatyuk, M.
10.1101/2024.12.04.626828 — cell biology — Posted on 2024-12-05
4406 Functional gene embeddings improve rare variant polygenic risk scores
Londhe, S.; Lindner, J.; Chen, Z.; Holtkamp, E.; Holzlwimmer, F. R.; Casale, F. P.; Brechtmann, F.; Gagneur, J.
10.1101/2024.07.22.604535 — genetics — Posted on 2024-12-05
4408 Microglial cathepsin B promotes neuronal efferocytosis during brain development
Silva, N. J.; Anderson, S.; Mula, S.; Escoubas, C. C.; Nakajo, H.; Molofsky, A. V.
10.1101/2024.12.03.626596 — neuroscience — Posted on 2024-12-04
4411 The histone demethylase KDM5 has insulator activity in the brain
Yheskel, M.; Castiglione, M. A.; Kelly, R. D.; Sidoli, S.; Secombe, J.
10.1101/2024.12.04.626780 — genetics — Posted on 2024-12-04
4412 Conserved interhemispheric morphogenesis in amniotes preceded the evolution of the corpus callosum
Noji, R.; Kaneko, M.; Abe, T.; Kiyonari, H.; Nishikawa, Y.; Kumamoto, T.; Gotoh, H.; Ohtaka-Maruyama, C.; Ono, K.; Yoshizawa, T.; Nomura, T.
10.1101/2024.12.03.625459 — developmental biology — Posted on 2024-12-04
4415 Revealing rhythm categorization in human brain activity
Barbero, F. M.; Lenc, T.; Jacoby, N.; Polak, R.; Varlet, M.; Nozaradan, S.
10.1101/2024.12.04.626390 — neuroscience — Posted on 2024-12-04
4416 Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity followed by gradual electrochemical maturation
Bershteyn, M.; Zhou, H.; Fuentealba, L.; Chen, C.; Subramanyam, G.; Cherkowsky, D.; Salvatierra, J.; Sezan, M.; Maury, Y.; Havlicek, S.; Kriks, S.; Lee, S.; Watson, M.; Au, W.; Qiu, Y.; Nesterova, A.; Anderson, D.; Feld, B. G.; Kuzmenko, O.; Grimmett, M. E.; Hosford, V.; Jung, J.-H.; Kowal, T.; Bulfone, A.; Priest, C.; Palop, J.; Nicholas, C. R.
10.1101/2024.12.03.626662 — neuroscience — Posted on 2024-12-04
4418 Cross-linked agarose-gelatine beads as a substrate for investigating biofilms of bacterial pathogens
Roizman, D.; Herzog, M.; Nath, A.; Pachaimuthu, N.; Hujeirat, A.; Kuropka, B.; Rolff, J.; Rodriguez-Rojas, A.
10.1101/2024.08.16.608334 — microbiology — Posted on 2024-12-04
4420 An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection.
Guo, Y.; Aufiero, M. A.; Mills, K. A. M.; Grassmann, S. A.; Kim, H.; Zumbo, P.; Gjonbalaj, M.; Billips, A.; Mar, K. B.; Yu, Y.; Betel, D.; Sun, J. C.; Hohl, T. M.
10.1101/2024.10.24.620079 — immunology — Posted on 2024-12-04
4421 Oral supplementation with Nicotinamide Riboside treatment protects RGCs in DBA/2J mouse model
Zhang, N.; Li, Y.; Zhang, X.; Chrenek, M. A.; Wang, J.; Girardot, P. E.; Sellers, J. T.; Brenner, C.; Cui, X.; Geisert, E. E.; Nickerson, J.; Boatright, J.
10.1101/2024.12.03.626460 — neuroscience — Posted on 2024-12-04
4423 Mastering the Manu - How humans create large splashes
Rohilla, P.; Choi, D.; Wallace, H.; Yung, K. L.; Deora, J.; Lele, A.; Bhamla, S.
10.1101/2024.12.03.626658 — biophysics — Posted on 2024-12-04
4425 Human heart assembloids with autologous tissue-resident macrophages recreate physiological immuno-cardiac interactions
O'Hern, C.; Caywood, S.; Aminova, S.; Kiselev, A.; Volmert, B.; Wang, F.; Sewavi, M.-L.; Cao, W.; Dionise, M.; Muniyandi, P.; Popa, M.; Basrai, H.; Skoric, M.; Boulos, G.; Huang, A.; Nunez-Regueiro, I.; Chalfoun, N.; Park, S.; Ashammakhi, N.; Zhou, C.; Contag, C. H.; Aguirre, A.
10.1101/2024.11.13.623051 — bioengineering — Posted on 2024-12-04
4430 Loss of Pigment Epithelium Derived Factor Sensitizes C57BL/6J Mice to Light-Induced Retinal Damage
Shelton, D. A.; Papania, J. T.; Getz, T. E.; Sellers, J. T.; Girardot, P. E.; Chrenek, M. A.; Grossniklaus, H. E.; Boatright, J. H.; Nickerson, J. M.
10.1101/2024.12.04.626802 — molecular biology — Posted on 2024-12-04
4432 Multi-omics analysis of the mechanism of alfalfa and wheat-induced rumen flatulence in Xizang sheep
Zhao, W.; Song, T.; Wu, J.; Zhang, X.; Khan, A.; Cui, J.; Shahzad, K.; Wang, G.; Zhaxi, Y.; Shi, M.; Jiang, X.; Li, L.; Liu, G.
10.1101/2024.12.04.626838 — microbiology — Posted on 2024-12-04
4433 Detection and characterization of Langya virus in Crocidura lasiura, Republic of Korea
Natasha, A.; Pye, S. E.; Park, K.; Rajoriya, S.; Yang, I.; Park, J.; Pangestu, H. S.; Kim, J.; Oh, Y.; Lopez, C. B.; Song, J.-W.; Kim, W.-K.
10.1101/2024.12.02.626520 — microbiology — Posted on 2024-12-04
4434 Folate prevents the autism-related phenotype caused by developmental pyrethroid exposure in prairie voles
Saferin, N.; Haseeb, I.; Taha, A. M.; Beecroft, S. E.; Pillai, S.; Neifer, A. E.; Lakkuru, R.; Kistler, B. P.; Nawor, C. N.; Malik, I.; Hasan, D.; Carlson, J. A.; Zade, K. K.; Dressel, S. P.; Carney, E. M.; Shah, R.; Gautam, S.; Vergis, J.; Neifer, K. L.; Johnson, Z. V.; Gustison, M. L.; Hall, F. S.; Burkett, J. P.
10.1101/2024.11.25.625285 — neuroscience — Posted on 2024-12-04
4438 PITHD1: An Endogenous Inhibitor of the 26S Proteasome During Cellular Dormancy
Amann, S. J.; Dong, K.; Roehsner, J.; Krall, D.; Grishkovskaya, I.; Kotisch, H.; Schleiffer, A.; Roitinger, E.; Pauli, A.; Martin, A.; Haselbach, D.
10.1101/2024.12.04.626795 — biochemistry — Posted on 2024-12-04
4440 Cardiac Applications of CRISPR/AAV-Mediated Precise Genome Editing
Zheng, Y.; Mayourian, J.; King, J. S.; Li, Y.; Bezzerides, V. J.; Pu, W. T.; VanDusen, N. J.
10.1101/2024.12.03.626493 — genetics — Posted on 2024-12-04
4443 Expanding the HP1a-binding consensus and molecular grammar for heterochromatin assembly
Colmenares, S. U.; Tsukamoto, S.; Karpen, G.; Mofrad, M.; Brennan, L. D.; Hickmann, C.
10.1101/2024.12.03.626544 — molecular biology — Posted on 2024-12-04
4446 Platelet bioenergetics correlate with skeletal muscle metabolism in C57BL/6J mice
Wilkinson, M. S.; Ferguson, E. J.; Bureau, J.; Veeneman, J. L.; Lima, P. D.; McGlory, C.; Dunham-Snary, K. J.
10.1101/2024.12.03.626404 — molecular biology — Posted on 2024-12-04
4447 Experimental monkeypox virus infection in rats
Rockx, B.; van Keulen, L. J.; Van der Poel, W. H. M.; Arien, K. K.; Vercauteren, K.; van de Water, S.; Harders-Westerveen, J.; Wichgers Schreur, P.; van der Giessen, J.; Maas, M.; Stockhofe, N.; Liesenborghs, L.
10.1101/2024.12.04.626788 — microbiology — Posted on 2024-12-04
4449 Contact Lens Wear Alters Transcriptional Responses to Pseudomonas aeruginosa in Both the Corneal Epithelium and the Bacteria
Kumar, N. G.; Grosser, M. R.; Wan, S. J.; Schator, D.; Ahn, E.; Jedel, E.; Nieto, V.; Evans, D. J.; Fleiszig, S. M. J.
10.1101/2024.12.03.626720 — microbiology — Posted on 2024-12-04
4450 A major entomoparasite interferes with Chikungunya transmission by Aedes albopictus
Martin, E.; Chanfi, A.-n.; Viginier, B.; Raquin, V.; Valiente Moro, C.; Minard, G.
10.1101/2024.12.04.626309 — microbiology — Posted on 2024-12-04
4451 HIV-1 protein coding sequences are present in relevant bacteria
Pelaez-Prestel, H. F.; Mozas-Gutierrez, J.; Lafuente, E. M.; Reche, P. A.
10.1101/2024.12.04.626764 — microbiology — Posted on 2024-12-04
4452 BEVA2.0: Modular Assembly of Golden Gate-Compatible Vectors with Expanded Utility for Genetic Engineering
Geddes, B. A.; Williamson, R.; Schumacher, J.; Ardi, A.; Levin, G.; Cervenka, E.; Huang, R.; diCenzo, G. C.
10.1101/2024.12.04.626608 — synthetic biology — Posted on 2024-12-04
4453 Rational engineering of allosteric protein switches by in silico prediction of domain insertion sites
Wolf, B.; Shehu, P.; Brenker, L.; von Bachmann, A.; Kroell, A.-S.; Southern, N.; Holderbach, S.; Eigenmann, J.; Aschenbrenner, S.; Mathony, J.; Niopek, D.
10.1101/2024.12.04.626757 — synthetic biology — Posted on 2024-12-04
4455 Structural analysis of tilvestamab in complex with AXL
Christakou, E.; Lopez, A. J.; Muruganandam, G.; Micklem, D.; Lorens, J. B.; Kursula, P.
10.1101/2024.12.04.626834 — biochemistry — Posted on 2024-12-04
4457 Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation
Basu, A. A.; Zhang, C.; Rouhimoghadam, M.; Vasudevan, A.; Reitsma, J. M.; Zhang, X.
10.1101/2024.12.03.626601 — biochemistry — Posted on 2024-12-04
4459 Structure of the SMYD2-PARP1 Complex Reveals Both Productive and Allosteric Modes of Peptide Binding
Zhang, Y.; Alshammari, E.; Sobota, J.; Spellmon, N.; Perry, E.; Cao, T.; Mugunamalwaththa, T.; Smith, S.; Brunzelle, J.; Wu, G.; Stemmler, T.; Jin, J.; Li, C.; Yang, Z.
10.1101/2024.12.03.626679 — biochemistry — Posted on 2024-12-04
4461 The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine
Burtnyak, L.; Yuan, Y.; Pan, X.; Gunaratne, L.; Silveira d'Almeida, G.; Martinelli, M.; Reed, C. J.; Fernandez, J.; Patel, B. I.; Marquez, I.; Ehrenhofer-Murray, A.; Swairjo, M. A.; Alfonzo, J. J.; Green, B. D.; Kelly, V. P.; de Crecy-Lagard, V.
10.1101/2024.12.03.625470 — biochemistry — Posted on 2024-12-04
4462 Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients
Randolph, H. E.; Aguirre-Gamboa, R.; Brunet-Ratnasingham, E.; Nakanishi, T.; Locher, V.; Ketter, E.; Brandolino, C.; Larochelle, C.; Prat, A.; Arbour, N.; Dumaine, A.; Finzi, A.; Durand, M.; Richards, J. B.; Kaufmann, D. E.; Barreiro, L. B.
10.1101/2024.12.03.626676 — genomics — Posted on 2024-12-04
4464 An accelerating, decreasing phylogenetic trend in SARS-CoV-2 genome compositional heterogeneity during the pandemic
Oliver, J. L.; Bernaola Galvan, P.; Carpena, P.; Perfectti, F.; Gomez Martin, C.; Castiglione, S.; Raia, P.; Verdu, M.; Moya, A.
10.1101/2024.12.03.625388 — evolutionary biology — Posted on 2024-12-04
4465 PTTG1-Mediated Pericyte Dysfunction Drives Diabetes-Induced Microvascular Dysfunction
Zhang, L.; Ren, L.; Zhang, J.; Xia, M.; Li, X.; Yao, M.; Ma, F.; Jiang, C.; Yao, J.; Yan, B.
10.1101/2024.12.02.626502 — molecular biology — Posted on 2024-12-04
4466 High-throughput discovery and deep characterization of cyclin-CDK docking motifs
Ord, M.; Winters, M. J.; Subbanna, M. S.; de Martin Garrido, N.; Cushing, V. I.; Kliche, J.; Benz, C.; Ivarsson, Y.; Greber, B. J.; Pryciak, P. M.; Davey, N. E.
10.1101/2024.12.03.625240 — molecular biology — Posted on 2024-12-04
4467 PTX3 Governs Fibroblast-Epithelial Dynamics in Lung Injury and Repair
Bammert, M.-T.; Kollak, I.; Hoffmann, J. N.; Peter, E.; Schlueter, H.; Li, J.; Campos, A. R.; Viollet, C.; Gantner, F.; Lize, M.; Thomas, M. J.; Le, Q.-H.
10.1101/2024.12.03.626584 — molecular biology — Posted on 2024-12-04
4469 In and out of replication stress: PCNA/RPA1-based dynamics of fork stalling and restart in the same cell
Dyankova-Danovska, T. K.; Uzunova, S. D.; Danovski, G.; Stamatov, R. S.; Kanev, P.-B. V.; Atemin, A. S.; Ivanova, A. V.; Stoynov, S. S.
10.1101/2024.12.03.626292 — molecular biology — Posted on 2024-12-04
4470 Usutu virus African 3.1 lineage, Portugal, 2021-2023
Queiros, J.; Silva, T.; Fontoura-Goncalves, C.; Magalhaes, I.; Moraga, A.; Contreras, M.; Almeida, T.; Lopes, A.; Abrantes, J.; da Silva, L. P.; Rodrigues, M.; Costa, J. B.; de Mello, G.; Goncalves, D.; Alves, P. C.; Hofle, U.
10.1101/2024.12.04.626753 — microbiology — Posted on 2024-12-04
4472 Systematic review and meta-analysis of protocols and yield of direct from sputum sequencing of Mycobacterium tuberculosis
Mann, B. C.; Loubser, J.; Omar, S.; Glanz, C.; Ektefaie, Y.; Jacobson, K. R.; Warren, R.; Farhat, M. R.
10.1101/2024.12.04.625621 — microbiology — Posted on 2024-12-04
4474 A method for authenticating the fidelity of Cryptococcus neoformans knockout collections
Jacobs, E.; Dragotakes, Q.; Kulkarni, M.; Dziedzic, A.; Jedlicka, A.; Hardwick, J. M.; Casadevall, A.
10.1101/2024.12.03.626716 — microbiology — Posted on 2024-12-04
4475 HIV-1 single transcription start site mutants display complementary replication functions that are restored by reversion
GC, K.; Lesko, S.; Emery, A. L.; Burnett, C.; Gopal, K.; Clark, S.; Swanstrom, R.; Sherer, N. M.; Telesnitsky, A.; Kharytonchyk, S.
10.1101/2024.12.04.626847 — microbiology — Posted on 2024-12-04
4479 Altered spike dynamics drives immune evasion of SARS-CoV-2
Ugurlu, H.; Salminen, P.; Yuan, M.; Fagerlund, R.; Mäkelä, A. R.; Zusinaite, E.; Kesti, T.; Rissanen, I.; Merits, A.; Wilson, I. A.; Saksela, K.
10.1101/2024.12.03.626570 — immunology — Posted on 2024-12-04
4480 Mapping Cryptic Phosphorylation Sites in the Human Proteome
Gasparotto, D.; Zanon, A.; Bonaldo, V.; Marchiori, E.; Casagranda, M.; Di Domenico, E.; Copat, L.; Asquini, T. F.; Rigoli, M.; Feltrin, S. V.; Lorenzo, N. L.; Lolli, G.; Pennuto, M.; Requena, J. R.; Stabelli, O. R.; Minervini, G.; Micheletti, C.; Spagnolli, G.; Faccioli, P.; Biasini, E.
10.1101/2024.12.03.626562 — biochemistry — Posted on 2024-12-04
4484 Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy Response.
Che, Y.; Lee, J.; Abou-Taleb, F.; Rieger, K. E.; Satpathy, A.; Chang, A. L. S.; Chang, H.
10.1101/2024.12.03.626669 — cancer biology — Posted on 2024-12-04
4489 Island population demography: Breeding dynamics and drivers of Gotland's iconic Golden Eagles
Singh, N. J.; Olofsson, R.; van der Meiden, A. J.; Lopez-Peinado, A.; Mansson, J.
10.1101/2024.11.02.621680 — ecology — Posted on 2024-12-04
4490 Sensorimotor integration enhances temperature stimulus processing
Anderson, L. S.; Costabile, J. D.; Schwinn, S.; Calderon, D.; Haesemeyer, M.
10.1101/2024.10.15.618474 — neuroscience — Posted on 2024-12-04
4491 Interoceptive Signals Bias Decision Making in Rhesus Macaques
Cardenas, M. A.; Le, R. P.; Champ, T. M.; O'Neill, D.; Fuglevand, A. J.; Gothard, K. M.
10.1101/2024.07.08.602563 — neuroscience — Posted on 2024-12-04
4492 4-Methyllumifrone (4-MU) can improve learning and memory after cerebral ischemia/reperfusion injury in rats
Tamouk, S.; Mirshekari jahangiri, H.; Kashafi Jahromi, E.; Hamblin, M. R.; Aboutaleb, N.; Ramezani, F.
10.1101/2024.11.29.626098 — neuroscience — Posted on 2024-12-04
4495 COEXIST: Coordinated single-cell integration of serial multiplexed tissue images
Heussner, R. T.; Watson, C. F.; Eddy, C. Z.; Wang, K.; Cramer, E. M.; Creason, A. L.; Mills, G. B.; Chang, Y. H.
10.1101/2024.05.05.592573 — bioinformatics — Posted on 2024-12-04
4496 Structural polymorphism of alpha-synuclein fibrils alters pathway of Hsc70 mediated disaggregation
Jaeger, S.; Tittelmeier, J.; Dang, T. L.; Bellande, T.; Redeker, V.; Buell, A. K.; Melki, R.; Nussbaum-Krammer, C.; Bukau, B.; Wentink, A. S.
10.1101/2024.12.02.626355 — biochemistry — Posted on 2024-12-04
4497 PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
Husremovic, T.; Siess, K. M.; Antonioli, S.; Piech, L.; Meier, V.; Grishkovskaya, I.; Kircheva, N.; Angelova, S. E.; Brandstaetter, A.; Veis, J.; Miocic-Stosic, F.; Anrather, D.; Hartl, M.; Truebestein, L.; Zagrovic, B.; Hann, S.; Bock, C.; Ogris, E.; Dudev, T.; Irwin, N. A. T.; Haselbach, D.; Leonard, T. A.
10.1101/2024.12.03.625870 — biochemistry — Posted on 2024-12-04
4498 Gene expression comparisons between captive and wild shrew brains reveal captivity effects
Bedoya Duque, M. A.; Thomas, W. R.; Dechmann, D. K. N.; Nieland, J. D.; Baldoni, C.; von Elverfeldt, D.; Muturi, M.; Corthals, A.; Davalos, L. M.
10.1101/2023.10.02.560583 — genetics — Posted on 2024-12-04
4499 Repeated extrinsic and anisotropic mechanical inputs promote polarized adherens junction elongation
Yang, X.; Ferraro, T.; Molnar, K.; Pontabry, J.; Malanda, S.-R.; Maghelli, N.; Royer, L. A.; Grill, S. W.; Myers, E. W.; Grigolon, S.; Labouesse, M.
10.1101/2024.07.09.602689 — developmental biology — Posted on 2024-12-04
4500 Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic adjuvant for vaccine development
Rizzo, G. P.; Sanches, R. C.; Chavero, C.; Bianchi, D. S.; Apuzzo, E.; Herrera, S. E.; Agazzi, M. L.; Cortez, M. L.; MARMISOLLE, W. A.; Keitelman, I. A.; Trevani, A. S.; Oliveira, S. C.; Azzaroni, O.; Smaldini, P. L.; Docena, G. H.
10.1101/2024.07.01.601578 — immunology — Posted on 2024-12-04
4504 Deciphering compromised speech-in-noise intelligibility in older listeners: the role of cochlear synaptopathy
Garrett, M.; Vasilkov, V.; Mauermann, M.; Devolder, P.; Wilson, J. L.; Gonzalez, L.; Henry, K. S.; Verhulst, S.
10.1101/2020.06.09.142950 — neuroscience — Posted on 2024-12-04
4507 SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth
Xiong, J.; Hao, H.; Qin, M.; Shi, L.; Chen, H.; Liu, C.; Tang, Z.; An, D.; Yu, W.; He, D.; Shao, C.; Yuan, S.; Yu, H.
10.1101/2024.05.04.591017 — cancer biology — Posted on 2024-12-04
4508 Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures
Converse, A.; Perry, M. J.; Dipali, S. S.; Isola, J. V.; Kelley, E. B.; Varberg, J. M.; Zelinkski, M. B.; Gerton, J. L.; Stout, M. B.; Pritchard, M. T.; Duncan, F. E.
10.1101/2024.12.03.626649 — cell biology — Posted on 2024-12-04
4509 Rejuvenating aged osteoprogenitors for bone repair
Reeves, J.; Tournier, P.; Becquart, P.; Carton, R.; Tang, Y.; Vigilante, A.; Fang, D.; Habib, S. J.
10.1101/2024.10.22.619605 — cell biology — Posted on 2024-12-04
4511 A compendium of bona fide reference markers for genuine plant-derived extracellular vesicles and their degree of phylogenetic conservation
Rodriguez de Lope, M. M.; Sanchez-Pajares, I. R.; Herranz, E.; Lopez-Vazquez, C. M.; Gonzalez-Moro, A.; Rivera-Tenorio, A.; Gonzalez-Sanz, C.; Sacristan, S.; Chicano-Galvez, E.; de la Cuesta, F.
10.1101/2024.11.21.624247 — molecular biology — Posted on 2024-12-04
4517 Sensory perception of fluctuating light in Arabidopsis
Belmonte, A.; Tissot, N.; Rabinovich, A.; Ploschuk, E.; Crocco, C.; Ulm, R.; Casal, J. J.
10.1101/2024.02.21.581400 — plant biology — Posted on 2024-12-04
4519 Hexokinase 1-mediated plant immunity under abiotic stress depends on chloroplast positioning
Bagshaw, S. B.; Kitashova, A.; Oezmen, B.; Yip, C. K.; Sueling, B. E.; Schroeder, L.; Kleine, T.; Naegele, T.
10.1101/2024.12.04.626761 — plant biology — Posted on 2024-12-04
4521 Indolent primary cutaneous B-cell lymphomas resemble persistent antigen reactions without signs of dedifferentiation
Griss, J.; Gansberger, S.; Oyarzun, I.; Drach, M. C.; Nguyen, V.; Shaw, L. E.; Mann, U.; Porkert, S.; Farlik, M.; Weninger, W.; Dolak, W.; Aschenbrenner, B.; Lichtenberger, B. M.; Wagner, C.; Simonitsch-Klupp, I.; Wagner, S.; Jonak, C.; Brunner, P. M.
10.1101/2022.12.16.520801 — cancer biology — Posted on 2024-12-04
4522 A comprehensive pharmacological survey across heterogeneous patient-derived GBM stem cell models
Elliott, R. J.; Nagle, P.; Furqan, M.; Dawson, J. C.; McCarthy, A.; Munro, A. F.; Drake, C.; Morrison, G. M.; Marand, M.; Ebner, D.; Pollard, S.; Brunton, V. G.; Frame, M. C.; Carragher, N.
10.1101/2024.11.27.625719 — cancer biology — Posted on 2024-12-04
4523 Towards Spectral Variation Analysis: A Data Quality Framework for Non-Targeted Methods
Nichani, K.; Uhlig, S.; San Martin, V.; Colson, B.; Hettwer, K.; Steinacker, U.; Kaspar, H.; Gowik, P.; Kemmlein, S.
10.1101/2024.11.27.625758 — bioinformatics — Posted on 2024-12-04
4524 Zymoseptoria tritici effectors structurally related to killer proteins UmV-KP4 and UmV-KP6 are toxic to fungi, and define extended protein families in fungi
de Guillen, K.; Mammri, L.; Gracy, J.; Padilla, A.; BARTHE, P.; Hoh, F.; Lahfa, M.; Rouffet, J.; Petit-Houdenot, Y.; Kroj, T.; Lebrun, M.-H.
10.1101/2024.10.14.618152 — biochemistry — Posted on 2024-12-04
4525 Structural polymorphism of alpha-synuclein fibrils alters pathway of Hsc70 mediated disaggregation
Jager, S.; Tittelmeier, J.; Dang, T. L.; Bellande, T.; Redeker, V.; Buell, A. K.; Melki, R.; Nussbaum-Krammer, C.; Bukau, B. G.; Wentink, A. S.
10.1101/2024.12.02.626355 — biochemistry — Posted on 2024-12-04
4526 VEXAS anemia is a mosaic erythroblastopenia
Rodrigues, F.; Hardouin, G.; El Hoss, S.; Ghoul, A.; Gautier, E.-F.; Dussiot, M.; Peltier, S.; Amireault, P.; Soldan, V.; Miccio, A.; Debili, M.; Jachiet, V.; Trovati, T.; Rossignol, J.; Allemand, E.; Mekinian, A.; Georgin-Lavialle, S.; Salma, M.; Soler, E.; Gleizes, P.-E.; O'Donohue, M.-F.; Kosmider, O.; Rodriguez, M.; Hermine, O.
10.1101/2024.12.02.623560 — cell biology — Posted on 2024-12-04
4527 Structure of the ciliary tip central pair reveals the unique role of the microtubule-seam binding protein SPEF1
Legal, T.; Joachimiak, E.; Parra, M.; Peng, W.; Tam, A.; Black, C. S.; Valente-Paterno, M.; Brouhard, G.; Gaertig, J.; Wloga, D.; Bui, K. H.
10.1101/2024.12.02.626492 — cell biology — Posted on 2024-12-04
4528 Shifts in Coral Reef Holobiont Communities in the High-CO2 Marine Environment of Iotorishima Island
Huerlimann, R.; Wee, H. B.; Alves dos Santos, M.; Kise, H.; Mizuyama, M.; Dudoit, A.; Jamodiong, E.; Satoh, N.; Soong, G. Y.; Kurihara, H.; Toonen, R. J.; Husnik, F.; Iguchi, A.; Ravasi, T.; Reimer, J. D.
10.1101/2024.12.02.626509 — microbiology — Posted on 2024-12-04
4531 Trehalose supports the growth of Aedes aegypti cells and modifies gene expression and dengue virus replication
Marten, A. D.; Haslitt, D. P.; Martin, C. A.; Swanson, D. H.; Kalera, K.; Johnson, U. G.; Swarts, B. M.; Conway, M. J.
10.1101/2024.12.03.626538 — microbiology — Posted on 2024-12-04
4532 Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection
Perugino, C.; Liu, H.; Feldman, J.; Marbourg, J.; Guy, T.; Hui, A.; Ingram, N.; Liebaert, J.; Chaudhary, N.; Tao, W.; Jacob-Dolan, C.; Hauser, B. M.; Mian, Z.; Nathan, A.; Zhao, Z.; Kaseke, C.; Tano-Menka, R.; Getz, M.; Senjobe, F.; Berrios, C.; Ofoman, O.; Manickas-Hill, Z.; Wesemann, D.; Lemieux, J.; Goldberg, M. B.; Nundel, K.; Moormann, A. M.; Marshak-Rothstein, A.; Larocque, R.; Ryan, E.; Iafrate, A. J.; Lingwood, D.; Gaiha, G.; Charles, R.; Balazs, A. B.; Pandit, A.; Naranbhai, V.; Schmidt, A.; Pillai, S.
10.1101/2024.11.29.624972 — immunology — Posted on 2024-12-04
4533 Galectin-9 binding to HLA-DR in dendritic cells controls immune synapse formation and T cell proliferation
Rodgers Furones, A.; Brands, T.; Fedorova, K.; Wijfjes, Z.; Classens, R.; Kroese, L.; Verdoes, M.; van Mierlo, G.; van Spriel, A. B.; Querol Cano, L.
10.1101/2024.11.29.625991 — immunology — Posted on 2024-12-04
4536 Structural polymorphism of alpha-synuclein fibrils alters pathway of Hsc70 mediated disaggregation
Jager, S.; Tittelmeier, J.; Dang, T. L.; Bellande, T.; Redeker, V.; Buell, A. K.; Melki, R.; Nussbaum-Krammer, C.; Bukau, B. G.; Wentink, A. S.
10.1101/2024.12.02.626355 — biochemistry — Posted on 2024-12-04
4538 An integrative approach for profiling antibody responses in bats to human pathogens
Toshkova, N.; Zhelyzkova, V.; Koseva, K.; Dimitrova, K.; Elshaer, F.; Lacombe, R. V.; Lecerf, M.; Pashov, A.; Dimitrov, J. D.
10.1101/2024.11.29.626104 — immunology — Posted on 2024-12-04
4541 Fingerprinting and chemotyping approaches reveal a wide genetic and metabolic diversity among wild hops (Humulus lupulus L.)
Ducrocq, F.; Piutti, S.; Henychova, A.; Villerd, J.; Laflotte, A.; Girardeau, L.; Grosjean, J.; Patzak, J.; Hehn, A.
10.1101/2024.12.03.626581 — plant biology — Posted on 2024-12-04
4542 Common mycelial network mediated inter-plant signals modulate plant biotic stress responses and defence against foliar pathogens
Orlovskis, Z.; Voronins, E.; Kotova, A.; Pugacevskis, D.; Blums, K.; Nakurte, I.; Silamikelis, I.; Lee, S.-J.
10.1101/2024.12.03.626652 — plant biology — Posted on 2024-12-04
4543 Variant filters using segregation information improve mapping of nectar-production genes in sunflower (Helianthus annuus L.)
Barstow, A. C.; McNellie, J. P.; Smart, B. C.; Keepers, K. G.; Prasifka, J. R.; Kane, N. C.; Hulke, B. S.
10.1101/2024.12.03.626666 — plant biology — Posted on 2024-12-04
4544 Mosaic integration of spatial multi-omics with SpaMosaic
Yan, X.; Ang, K. S.; Olst, L. v.; Edwards, A.; Watson, T.; Zheng, R.; Fan, R.; Li, M.; Gate, D.; Chen, J.
10.1101/2024.10.02.616189 — bioinformatics — Posted on 2024-12-04
4545 Histology-Guided Single-Cell Mass Spectrometry Imaging using Integrated Bright-field and Fluorescence Microscopy
Potthoff, A.; Niehaus, M.; Bessler, S.; Schwenzfeier, J.; Hoffmann, E.; Soehnlein, O.; Hoehndorf, J.; Dreisewerd, K.; Soltwisch, J.
10.1101/2024.12.03.626022 — cell biology — Posted on 2024-12-04
4546 Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts
Price, M. L.; Wyatt, R. A.; Correia, J.; Areej, Z.; Hinds, M.; Crastin, A.; Hardy, R. S.; Frost, M.; Gorvin, C. M.
10.1101/2024.12.03.626553 — cell biology — Posted on 2024-12-04
4548 Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures
Converse, A.; Perry, M. J.; Dipali, S. S.; Isola, J. V.; Kelley, E. B.; Varberg, J. M.; Zelinkski, M. B.; Gerton, J. L.; Stout, M.; Pritchard, M. T.; Duncan, F.
10.1101/2024.12.03.626649 — cell biology — Posted on 2024-12-04
4549 Toward AI-Resilient Screening of Nucleic Acid Synthesis Orders: Process, Results, and Recommendations
Wittmann, B. J.; Alexanian, T.; Bartling, C.; Beal, J.; Clore, A.; Diggans, J.; Flyangolts, K.; Gemler, B. T.; Mitchell, T.; Murphy, S. T.; Wheeler, N. E.; Horvitz, E.
10.1101/2024.12.02.626439 — synthetic biology — Posted on 2024-12-04
4557 Structural and functional interrelationship of histone H2A and its variants H2A.Z and H2A.W in Arabidopsis
Wang, Y.; Wu, J.; Yang, S.; Li, X.; Wang, J.; Lv, Q.; Zhu, X.; Lu, G.; Zhang, J.; Shen, W.-H.; Liu, B.; Lin, J.; Dong, A.
10.1101/2024.12.03.626673 — plant biology — Posted on 2024-12-04
4558 The MpANT-auxin loop modulates Marchantia polymorpha development
Dipp-Alvarez, M.; Lorenzo Manzanares, J. L.; Flores-Sandoval, E.; Mendez-Alvarez, D.; Espinal-Centeno, A.; Leon-Ruiz, J.; Olvera-Martinez, F.; Bowman, J.; Arteaga-Vazquez, M. A.; Cruz-Ramirez, A.
10.1101/2024.12.03.626703 — plant biology — Posted on 2024-12-04
4559 A computational Evo-Devo approach for elucidating the roles of PLETHORA transcription factors in regulating root development
Rodriguez-Herrera, J.; Galvan-Alcaraz, K. A.; Albarran-Hernandez, R. U.; Villa Nunez, J. P.; Rodriguez-Alonso, G.; Shishkova, S.
10.1101/2024.12.03.626639 — plant biology — Posted on 2024-12-04
4560 Best practice mass photometry: A guide to optimal single molecule mass measurement
Kratochvil, J.; van Wee, R.; Loewenthal, D.; Thiele, J. C.; Bardzil, J.; Iqbal, K.; Thorpe, S.; Kukura, P.
10.1101/2024.12.03.624087 — biophysics — Posted on 2024-12-04
4561 Morphological map of under- and over-expression of genes in human cells
Chandrasekaran, S. N.; Alix, E.; Arevalo, J.; Borowa, A.; Byrne, P. J.; Charles, W. G.; Chen, Z. S.; Cimini, B. A.; Deng, B.; Doench, J. G.; Ewald, J. D.; Fritchman, B.; Fuller, C. J.; Gaetz, J.; Goodale, A.; Haghighi, M.; Han, Y.; Hanifehlou, Z.; Hennig, H.; Hernandez, D.; Jacob, C. B.; James, T.; Jetka, T.; Kalinin, A. A.; Komalo, B.; Kost-Alimova, M.; Krawiec, T.; Marion, B. A.; Martin, G.; McCarthy, N. J.; Miller, L.; Monsees, A.; Moshkov, N.; Munoz, A. F.; Ogier, A.; Otrocka, M.; Rataj, K.; Root, D. E.; Rubbo, F.; Scrace, S. F.; Selinger, D. W.; Senft, R. A.; Sommer, P.; Thibaudeau, A.; T
10.1101/2024.12.02.624527 — bioinformatics — Posted on 2024-12-04
4564 Integrated Database of Force-Field Parameters, Experimental Measurements and Molecular Dynamics Simulations
Banas, P.; Mlynsky, V.; Ciz, D.; Furmanek, R.; Pilat, N.; Pauw, V.; Hachinger, S.; Sponer, J.; Martinovic, J.; Otyepka, M.
10.1101/2024.12.03.626554 — bioinformatics — Posted on 2024-12-04
4565 mRNArchitect: optimized design of mRNA sequences
Budzinska, M. A.; Leonard, T. E.; Chang, R. Y.; Chaudhary, N.; Cheetham, S. W.; Mercer, T. R.; Gunter, H. M.
10.1101/2024.12.03.626696 — bioinformatics — Posted on 2024-12-04
4566 Pirin does not bind to p65 or regulate NFkappaB-dependent gene expression
Meschkewitz, M.; Lisabeth, E. M.; Cab-Gomez, A. D.; Leipprandt, J.; Neubig, R. R.
10.1101/2024.12.03.626411 — biochemistry — Posted on 2024-12-04
4567 PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor
Husremovic, T.; Siess, K. M.; Antonioli, S.; Piech, L.; Meier, V.; Grishkovskaya, I.; Kircheva, N.; Angelova, S. E.; Brandstaetter, A.; Veis, J.; Miocic-Stosic, F.; Anrather, D.; Hartl, M.; Truebestein, L.; Zagrovic, B.; Hann, S.; Bock, C.; Ogris, E.; Dudev, T.; Irwin, N. A. T.; Haselbach, D.; Leonard, T. A.
10.1101/2024.12.03.625870 — biochemistry — Posted on 2024-12-04
4571 Farming with Alternative Pollinators for Increased Biodiversity and Smallholder Incomes in Zimbabwe
Allebone-Webb, S.; Gossau, F.; Orland, C.; Bara, G.; Fioekou, C.; Matsika, A.; Riber, K.; Mahaman Dioula, B.
10.1101/2024.11.29.626070 — ecology — Posted on 2024-12-04
4572 Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models
Hu, R.; Lee, L. B.; Zhu, B.; Cai, P.; Tao, Y.; Youssef, M.; Girrbach, G. I.; Song, Y.; Wang, X.; Tsankov, A.; Buxbaum, J. D.; Ma, S.; Yang, N.
10.1101/2024.12.03.626438 — developmental biology — Posted on 2024-12-04
4574 Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21
LI, X.; WANG, Q.; GUO, A.; CHEN, Q.; QIU, Y.; LI, Y.; ZHANG, L.; GUO, Y.; MENG, X.; LI, S.; LIU, G.; ZHANG, L.; LIU, J.; LI, X.; CAI, L.; CHENG, X.; LIU, C.; WANG, X.; Wood, A.; Murray, J.; LIU, G.; LI, J.; HUANG, X.; DOU, D.
10.1101/2024.12.03.626577 — cell biology — Posted on 2024-12-04
4577 TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence
Kahlhofer, J.; Marchet, N.; Seifert, B.; Zubak, K.; Hotze, M.; Egger, A.-S.; Manzl, C.; Weyer, Y.; Weys, S.; Offterdinger, M.; Herzog, S.; Reiterer, V.; Kwiatkowski, M.; Wortmann, S. B.; Nemati, S.; Mayr, J. A.; Zschocke, J.; Radlinger, B.; Thedieck, K.; Huber, L. A.; Farhan, H.; de Araujo, M. E.; Kaser, S.; Scholl-Burgi, S.; Karall, D.; Teis, D.
10.1101/2024.10.29.620655 — cell biology — Posted on 2024-12-04
4578 Exploring mitonuclear interactions in the regulation of cell physiology: insights from interspecies cybrids
Gaertner, K.; Tapanainen, R.; Saari, S.; Fekete, Z.; Goffart, S.; Pohjoismaki, J. L. O.; Dufour, E.
10.1101/2024.12.03.626354 — cell biology — Posted on 2024-12-04
4579 Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression
Nesbit, C.; Martin, W.; Czechanski, A.; Byers, C.; Raghupathy, N.; Ferraj, A.; Stumpff, J.; Reinholdt, L. G.
10.1101/2024.12.03.626395 — cell biology — Posted on 2024-12-04
4580 Vaginal Microbiome and Inflammation Among Chinese Women.
Zhang, Y.; Schuppe-Koistinen, I.; Wang, H.; Pelechano, V. G.; Tian, X.; Chen, W.-H.; Gao, G.; Du, J.
10.1101/2024.11.30.626174 — microbiology — Posted on 2024-12-04
4581 Individual differences in probabilistic learning and updating predictive representations in individuals with obsessive-compulsive tendencies
Brezoczki, B.; Farkas, B. C.; Hann, F.; Pesthy, O.; Toth-Faber, E.; Farkas, K.; Csigo, K.; Nemeth, D.; Vekony, T.
10.1101/2024.12.03.626598 — neuroscience — Posted on 2024-12-04
4582 Temporal Configuration as a New Feature of Sound: Psychological and Neurophysiological Evidence, Cross-species Consistency and Underlying Neuronal Mechanisms
Zhai, Y.; Du, X.; Song, P.; Xu, h.; Ye, h.; Bao, X.; Mehmood, I.; Tanigawa, H.; Niu, W.; Tu, Z.; Chen, P.; Zhang, T.; Zhang, L.; Zhao, X.; Yu, X.
10.1101/2024.12.02.626513 — neuroscience — Posted on 2024-12-04
4585 Tribus: Semi-automated discovery of cell identities and phenotypes from multiplexed imaging and proteomicdata
Kang, Z.; Szabo, A.; Farago, T.; Perez-Villatoro, F.; Junquera, A.; Saundarya, S.; Launonen, I.-M.; Anttila, E.; Casado, J.; Elias, K.; Virtanen, A.; Haltia, U.-M.; Farkkila, A.
10.1101/2024.03.13.584767 — bioinformatics — Posted on 2024-12-04
4587 Amyloid beta Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer's Disease
Prakash, P.; Manchanda, P.; Paouri, E.; Bisht, K.; Sharma, K.; Rajpoot, J.; Wendt, V.; Hossain, A.; Wijewardhane, P. R.; Randolph, C. E.; Chen, Y.; Stanko, S.; Gasmi, N.; Gjojdeshi, A.; Card, S.; Fine, J.; Jethava, K. P.; Clark, M. G.; Dong, B.; Ma, S.; Crockett, A. M.; Thayer, E. A.; Nicolas, M.; Davis, R.; Hardikar, D.; Allende, D.; Prayson, R.; Zhang, C.; Davalos, D.; Chopra, G.
10.1101/2023.06.04.543525 — neuroscience — Posted on 2024-12-04
4588 Sparse spatial scaffolding for visual working memory
Liu, B.; Alexopoulou, Z.-S.; Kong, S.; Zonneveld, A.; van Ede, F.
10.1101/2023.07.05.547765 — neuroscience — Posted on 2024-12-04
4590 Pharmacological CDK4/6 inhibitors promote senescence-associated lysosomal alterations and enhance sensitivity to lysosomotropic agents in breast cancer
Nehme, J.; Massen, S.; Bravaccini, S.; Zanoni, M.; Gianni, C.; De Giorgi, U.; Soto-Gamez, A.; Altulea, A.; Gheorghe, T.; Wang, B.; Demaria, M.
10.1101/2024.08.22.609150 — cancer biology — Posted on 2024-12-04
4593 Advanced Peptide Nanoparticles Enable Robust and Efficient delivery of gene editors across cell types
Gustafsson, O.; Krishna, S.; Borate, S.; Ghaeidamini, M.; Liang, X.; Saher, O.; Cuellar, R.; Birdsong, B. K.; Roudi, S.; Estupinan, Y. H.; Alici, E.; Smith, E. C.; Esbjörner, E. K.; Spuler, S. K.; de Jong, O. G.; Escobar, H.; Nordin, J. Z.; Andaloussi, S. E.
10.1101/2024.11.27.624305 — bioengineering — Posted on 2024-12-04
4599 The identification of a SARs-CoV2 S2 protein-derived peptide with super-antigen-like stimulatory properties on T-cells
Tu, T. H.; Bennani, F. E.; Masroori, N.; Liu, C.; Nemati, A.; Rozza, N.; Grunbaum, A. M.; Kremer, R.; Milhalcioiu, C.; Roy, D.-C.; Rudd, C.
10.1101/2024.11.26.624714 — immunology — Posted on 2024-12-04
4600 The beginnings of light-dependent nuclear relocation in land plants
Iwabuchi, K.; Yagi, H.; Moriya, K. C.; Komatsu, A.; Sakai, Y.; Shimada, T.; Nishihama, R.; Kohchi, T.; Harada, A.; Watanabe, Y.-h.; Ueda, H.; Hara-Nishimura, I.
10.1101/2024.09.11.611950 — plant biology — Posted on 2024-12-04
4605 DeepCristae, a CNN for the restoration of mitochondria cristae in live microscopy images
Papereux, S.; Leconte, L.; Valades-Cruz, C. A.; Liu, T.; Dumont, J.; Chen, Z.; Salamero, J.; Kervrann, C.; Badoual, A.
10.1101/2023.07.05.547594 — bioinformatics — Posted on 2024-12-04
4606 Microbial lysates as low-cost serum replacements in cellular agriculture media formulation
Dolgin, J.; Chakravarty, D.; Sullivan, S. F.; Cai, Y.; Lim, T.; Yamaguchi, P.; Balkan, J. E.; Xu, L.; Olawoyin, A. D.; Lee, K.; Kaplan, D. L.; Nair, N. U.
10.1101/2024.10.28.620756 — bioengineering — Posted on 2024-12-04
4608 Bringing TB genomics to the clinic: A comprehensive pipeline to predict antimicrobial susceptibility from genomic data, validated and accredited to ISO standards.
Horan, K.; Viberg, L.; Ballard, S.; Globan, M.; Bond, K.; Webb, J.; Dorji, T.; Williamson, D.; Sait, M.; Tay, E. L.; Denholm, J.; Seemann, T.; Howden, B.; Sherry, N.
10.1101/2023.11.04.565651 — genomics — Posted on 2024-12-04
4609 Detection and characterization of Langya virus in Crocidura lasiura, Republic of Korea
Natasha, A.; Pye, S. E.; Park, K.; Rajoriya, S.; Yang, I.; Park, J.; Pangestu, H. S.; Kim, J.; Oh, Y.; Lopez, C. B.; Song, J.-W.; Kim, W.-K.
10.1101/2024.12.02.626520 — microbiology — Posted on 2024-12-04
4610 Temporal Lobe Epilepsy is dominated by Region Specific Interictal Cortical Inhibition
Kienitz, R.; Strzelczyk, A.; Spyrantis, A.; Konczalla, J.; Rosenow, F.; Strueber, M.
10.1101/2024.11.30.626179 — neuroscience — Posted on 2024-12-04
4617 Not so local: the population genetics of convergent adaptation in maize and teosinte.
Tittes, S.; Lorant, A.; McGinty, S.; Holland, J. B.; Sanchez-Gonzalez, J. d. J.; Seetharam, A. S.; Tenaillon, M. I.; Ross-Ibarra, J.
10.1101/2021.09.09.459637 — evolutionary biology — Posted on 2024-12-03
4618 Influenza A virus transcription generates capped cRNAs that activate RIG-I
Elshina, E.; Pitre, E.; Mendes, M.; Schweibenz, B.; Fan, R.; French, H.; Park, J. W.; Wang, W.; Poon, L.; Marcotrigiano, J.; Russell, A. B.; te Velthuis, A. J. W.
10.1101/2024.11.12.623191 — microbiology — Posted on 2024-12-03
4619 A neural correlate of individual odor preference in Drosophila
Churgin, M.; Lavrentovich, D.; Smith, M. A.-Y.; Gao, R.; Boyden, E. S.; de Bivort, B. L.
10.1101/2021.12.24.474127 — neuroscience — Posted on 2024-12-03
4620 Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses myeloid leukemia stemness
Pawar, A. S.; Somers, P.; Alex, A.; George, S. S.; Antony, C.; Verner, R.; White-Brown, S. K.; Khera, M.; Mendoza-Figueroa, M. S.; Liu, K. F.; Morrissette, J. J. D.; Paralkar, V. R.
10.1101/2024.11.29.625909 — cancer biology — Posted on 2024-12-03
4623 The SWIB domain-containing DNA topoisomerase I of Chlamydia trachomatis mediates DNA relaxation
Shen, L.; Diggs, C.; Ferdous, S.; Dos Santos, A. B.; Wolf, N.; Terrebonne, A.; Lorenzo Carvajal, L.; Zhong, G.; Ouellette, S. P.; Tse-Dinh, Y.-C.
10.1101/2024.12.03.626651 — molecular biology — Posted on 2024-12-03
4624 Soil microbes prefer organic acids over sugars in simulated root exudation
Wiesenbauer, J.; Gorka, S.; Jenab, K.; Schuster, R.; Kumar, N.; Rottensteiner, C.; Koenig, A.; Kraemer, S.; Inselsbacher, E.; Kaiser, C.
10.1101/2024.12.03.626624 — microbiology — Posted on 2024-12-03
4625 A fast-track, high-throughput screening platform for biological nitrification inhibitors discovery based on soil relevant ammonia oxidizing strains
Kanellopoulos, A. E.; Malits, A.; Ribeiro, H.; Kerou, M.; Ghatak, A.; Chaturvedi, P.; Weckwerth, W.; Karpouzas, D. G.; Schleper, C.; Papadopoulou, E. S.
10.1101/2024.12.03.626636 — microbiology — Posted on 2024-12-03
4631 KP.2-based monovalent mRNA vaccines robustly boost antibody responses to SARS-CoV-2
Wang, Q.; Mellis, I. A.; Wu, M.; Bowen, A.; Gherasim, C.; Valdez, R.; Shah, J. G.; Purpura, L. J.; Yin, M. T.; Gordon, A.; Guo, Y.; Ho, D. D.
10.1101/2024.12.02.626472 — microbiology — Posted on 2024-12-03
4635 Dynamic interplay between RNA N6-methyladenosine modification and porcine reproductive and respiratory syndrome virus infection
Tong, J.; Wang, Z.; Li, J.; Ma, S.; Liu, M.; Zhan, Y.; Jin, F.; Wang, W.; He, M.; Yang, Y.; Tang, Y.-D.; Wang, P.; Zhang, W.; Liu, B.
10.1101/2024.12.03.626656 — microbiology — Posted on 2024-12-03
4636 TurboID-based proximity labeling discovers ABCF2 as an adhesion receptor for the zoonotic pathogen Pasteurella multocida
Wang, F.; Shang, Y.; Chen, M.; Wang, Z.; Liu, H.; Hua, L.; Li, W.; Chen, H.; He, Q.; Wu, B.; Peng, Z.
10.1101/2024.12.03.626657 — microbiology — Posted on 2024-12-03
4639 Unveiling Cell Wall Structure and Echinocandin Response in Candida auris and Candida albicans via Solid-State NMR
Dickwella Widanage, M. C.; Singh, K.; Li, J.; Reddy Yarava, J.; Scott, F. J.; Xu, Y.; Gow, N. A. R.; Mentink-Vigier, F.; Wang, P.; Lamoth, F.; Wang, T.
10.1101/2024.12.02.626508 — microbiology — Posted on 2024-12-03
4640 Trehalose supports the growth of Aedes aegypti cells and modifies gene expression and dengue virus replication
Conway, M. J.; Marten, A. D.; Haslitt, D. P.; Martin, C. A.; Swanson, D. H.; Kalera, K.; Johnson, U. G.; Swarts, B. M.
10.1101/2024.12.03.626538 — microbiology — Posted on 2024-12-03
4642 Rebuilding the autoimmune-damaged corneal stroma through topical lubrication
Efraim, Y.; Chen, F. Y. T.; Niknezhad, S. V.; Pham, D.; Cheong, K. N.; An, L.; Sinada, H.; McNamara, N. A.; Knox, S.
10.1101/2024.11.29.626078 — immunology — Posted on 2024-12-03
4645 DNA methylation and gene expression trajectories of human postprandial metabolism
Costeira, R.; Daimiel Ruiz, L.; Gehrmann, T.; Bogaards, F.; Villicana, S.; Sinke, L.; Raza, Y.; Tomlinson, M.; Christiansen, C.; Heijmans, B. T.; Slagboom, P. E.; Spector, T. D.; Small, K. S.; Alcala-Diaz, J. F.; Rangel-Zuniga, O.; Lopez-Miranda, J.; Waldenberger, M.; Berry, S. E.; Ordovas, J. M.; Bell, J. T.
10.1101/2024.11.29.626085 — genomics — Posted on 2024-12-03
4648 Loss of chromogranin A and catestatin affect pancreatic islet homeostasis, endocrine function, and neurotransmitters
Muntjewerff, E. M.; Epremidze, D.; Nezhyva, M.; Bootsma, M.; Mannaa, A.; Ikebuchi, H.; Nilsson, A. M.; Andren, P.; Jansson, E.; Mahata, S. K.; Christoffersson, G.
10.1101/2024.11.29.626063 — immunology — Posted on 2024-12-03
4649 FCRL4 and exhausted B cell signature in tumor infiltrating B cells from lung cancer
Bryushkova, E. A.; Shchoka, E. V.; Lukyanov, D. K.; Gikalo, M. B.; Mushenkova, N.; Laktionov, K. K.; Kazakov, A. M.; Khalmurzaev, O. A.; Matveev, V. B.; Chudakov, D. M.; Serebrovskaya, E. O.
10.1101/2024.11.29.626090 — immunology — Posted on 2024-12-03
4652 Epigenetic study of the long-term effects of Gulf War illness
Jones, B. C.; O'Callaghan, J. P.; Ashbrook, D. G.; Lu, L.; Prins, P.; Zhao, W.; Mozhui, K.
10.1101/2024.11.29.626040 — pharmacology and toxicology — Posted on 2024-12-03
4654 Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes
Perez-Villatoro, F.; van Wagensveld, L.; Shabanova, A.; Junquera, A.; Kang, Z.; Niemiec, I.; Falco, M. M.; Anttila, E.; Casado, J.; Marcus, E.; Kahelin, E.; Chamchougia, F.; Salko, M.; Shah, S.; Russo, S.; Chiaro, J.; Gronholm, M.; Sonke, G. S.; Van de Vijver, K. K.; Kruitwagen, R. F.; van der Aa, M.; Virtanen, A.; Cerullo, V.; Vaharautio, A.; Sorger, P. K.; Horlings, H. M.; Farkkila, A.
10.1101/2024.11.29.626039 — cancer biology — Posted on 2024-12-03
4655 Beta cells are essential drivers of pancreatic ductal adenocarcinoma development
Garcia, C. C.; Venkat, A.; McQuaid, D. C.; Agabiti, S. S.; Tong, A.; Cardone, R. L.; Starble, R.; Sogunro, A.; Jacox, J. B.; Ruiz, C. F.; Kibbey, R.; Krishnaswamy, S.; Muzumdar, M. D.
10.1101/2024.11.29.626079 — cancer biology — Posted on 2024-12-03
4656 Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses myeloid leukemia stemness
Pawar, A. S.; Somers, P.; Alex, A.; George, S. S.; Antony, C.; Verner, R.; White-Brown, S. K.; Khera, M.; Mendoza-Figueroa, M. S.; Liu, K. F.; Morrissette, J.; Paralkar, V. R.
10.1101/2024.11.29.625909 — cancer biology — Posted on 2024-12-03
4657 PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
Desai, K.; Tiburcio, P. D. B.; Warne, A.; Nabbi, A.; Zhou, S.; Reiff, S. D.; Campbell, M. E.; Chen, K. S.
10.1101/2024.11.29.626084 — cancer biology — Posted on 2024-12-03
4659 Flow-Induced Vascular Remodeling On-Chip: Implications for Anti-VEGF Therapy
Mirzapour-Shafiyi, F.; Huber, E.; Karr, L.; Tong, J.; Bausch, A. R.; Simmel, F. C.; Alim, K.
10.1101/2024.11.29.625475 — biophysics — Posted on 2024-12-03
4663 Soft, 3D printed muscle ultrasound phantom with structurally tunable B-mode echo intensity
Gillespie, S.; Collins, C.; Perreault, E. J.; Sun, C.; Balogun, O.; Murray, W. M.
10.1101/2024.11.29.625078 — bioengineering — Posted on 2024-12-03
4666 Genomic data reveal a north-south split and introgression history of blood fluke (Schistosoma haematobium) populations from across Africa
Platt, R. N.; Enabulele, E. E.; Adeyemi, E.; Agbugui, M. O.; Ajakaye, O. G.; Amaechi, E. C.; Ejikeugwu, C. E.; Igbeneghu, C.; Njom, V. S.; Dlamini, P.; Arya, G. A.; Diaz, R.; Rabone, M.; Allan, F.; Webster, B.; Emery, A.; Rollinson, D.; Anderson, T. J.
10.1101/2024.08.06.606828 — evolutionary biology — Posted on 2024-12-03
4669 Single cell transcriptomics reveal mast cell heterogeneity in the human gut
Hussein, H.; Modave, E.; Stakenborg, N.; Delfini, M.; Vandereyken, K.; Sifrim, A.; Voet, T.; Boeckxstaens, G. E.
10.1101/2024.11.29.626054 — immunology — Posted on 2024-12-03
4670 Hyperactive neuronal networks facilitate tau spread in an Alzheimer's disease mouse model
Barbour, A. J.; Hoag, K.; Cornblath, E. J.; Chavez, A.; Lucas, A.; Li, X.; Zebrowitz, S.; Hassman, C.; Lee, E. B.; Davis, K. A.; Lee, V. M. Y.; Talos, D. M.; Jensen, F. E.
10.1101/2024.12.01.625514 — neuroscience — Posted on 2024-12-03
4671 Blood Omics Models for System-Specific Mortality Risk Estimation
Fuentealba, M.; Arpawong, T. E.; Schneider, K.; Crimmins, E. M.; Furman, D.
10.1101/2024.11.27.625723 — systems biology — Posted on 2024-12-03
4672 High-resolution profiling reveals coupled transcriptional and translational regulation of transgenes
Peterman, E. L.; Ploessl, D. S.; Love, K. S.; Sanabria, V.; Daniels, R. F.; Johnstone, C. P.; Godavarti, D. R.; Kabaria, S. R.; Oakes, C. G.; Pai, A. A.; Galloway, K. E.
10.1101/2024.11.26.625483 — synthetic biology — Posted on 2024-12-03
4673 Identifying novel links between cardiovascular disease and insomnia by Drosophila modeling of genes from a pleiotropic GWAS locus
Abou Daya, F.; Mandigo, T.; Ober, L.; Patel, D.; Maher, M.; Math, S.; Tchio, C.; Walker, J. A.; Saxena, R.; Melkani, G. C.
10.1101/2023.07.24.550429 — physiology — Posted on 2024-12-03
4674 mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
Stavrides, P.; Goulbourne, C. N.; Peddy, J.; Huo, C.; Rao, M.; Khetarpal, V.; Marchionini, D. M.; Nixon, R. A.; Yang, D.-S.
10.1101/2024.05.29.596471 — pathology — Posted on 2024-12-03
4675 Structural and functional insights into activation and regulation of the dynein-dynactin-NuMA complex
Aslan, M.; d'Amico, E. A.; Cho, N. H.; Taheri, A.; Zhao, Y.; Zhong, X.; Blaauw, M.; Carter, A. P.; Dumont, S.; Yildiz, A.
10.1101/2024.11.26.625568 — biophysics — Posted on 2024-12-03
4678 Structural variants contribute to phenotypic variation in maize
Catlin, N. S.; Agha, H. I.; Platts, A. E.; Munasinghe, M.; Hirsch, C. S.; Josephs, E. B.
10.1101/2024.06.14.599082 — genetics — Posted on 2024-12-03
4680 Towards comprehensive individual tree species mapping in diverse tropical forests by harnessing temporal and spectral dimensions
Ball, J. G. C.; Jaffer, S.; Laybros, A.; Prieur, C.; Jackson, T. D.; Madhavapeddy, A.; Barbier, N.; Vincent, G.; Coomes, D.
10.1101/2024.06.24.600405 — ecology — Posted on 2024-12-03
4681 A tunable and versatile chemogenetic near infrared fluorescent reporter
El Hajji, L.; Bunel, B.; Joliot, O.; Li, C.; Tebo, A. G.; Rampon, C.; Volovitch, M.; Fischer, E.; Pietrancosta, N.; Perez, F.; Morin, X.; VRIZ, S.; Gautier, A.
10.1101/2024.04.05.588310 — cell biology — Posted on 2024-12-03
4682 ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function
Ha, K.; Loeb, G. B.; Park, M.; Gupta, M.; Akiyama, Y.; Argiris, J.; Pinedo, A.; Park, C. H.; Brandes, N.; Ritu, F.; Ye, C. J.; Reiter, J. F.; Delling, M.
10.1101/2023.12.04.570035 — cell biology — Posted on 2024-12-03
4683 Sperm fertility restoration in mice suffering from oligo-astheno-teratozoospermia by in vivo injection and electroporation of naked mRNA
Vilpreux, C.; Martinez, G.; Fourquin, P.; Court, M.; Appaix, F.; Duteyrat, J. L.; Henry, M.; Vollaire, J.; Ayad, C.; Yavuz, A.; De Macedo, L.; Chevalier, G.; Del Llano, E.; Lambert, E.; Ahmed Conte, S.; Wehbe, Z.; Giordani, E.; Josserand, V.; Brocard, J.; Coutton, C.; Verrier, B.; Ray, P. F.; Loeuillet, C.; Arnoult, C.; Escoffier, J.
10.1101/2023.12.12.571239 — molecular biology — Posted on 2024-12-03
4684 PAG orchestrates T cell immune synapse function by binding to actin
Moore, E. K.; Strazza, M.; Hu, X.; Tymm, C.; Paiola, M.; Shannon, M. J.; Xie, X.; Bukhari, S.-S.; Lerrer, S.; Mace, E. M.; Winchester, R.; Mor, A.
10.1101/2024.11.29.625440 — immunology — Posted on 2024-12-03
4686 The transient and dynamic nature of splitter cells derive from behavior
Chaix-Echel, N.; Dagar, S.; Alexandre, F.; Boraud, T.; Rougier, N. P.
10.1101/2024.06.07.597927 — neuroscience — Posted on 2024-12-03
4687 Inhibitory control of locomotor statistics in walking Drosophila
Gattuso, H.; van Hassel, K. A.; Freed, J. D.; Nunez, K. M.; de la Rea, B.; May, C. E.; Ermentrout, B.; Victor, J. D.; Nagel, K. I.
10.1101/2024.04.15.589655 — neuroscience — Posted on 2024-12-03
4688 Effect of MisMatch Repair Deficiency on metastasis occurrence modelized in a syngeneic mouse model
Laplante, P.; Rosa, R.; Nebot-Bral, L.; Goulas, J.; Nikolaev, S.; Silvin, A.; Kannouche, P.
10.1101/2024.11.29.626023 — cancer biology — Posted on 2024-12-03
4689 Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state
Corry, S. M.; Sakhnevych, S.; Mohamed, N. E.; Malla, S. B.; Byrne, R.; Young, A.; Amirkhah, R.; Bull, C.; Lees, A.; Redmond, K.; Lannagan, T.; Ridgway, R. A.; Taggart, F.; Fisher, N.; Maughan, T.; Lawler, M.; Campbell, A.; Leedham, S.; Ryan, A.; Longley, D.; Small, D.; Sansom, O.; Dunne, P. D.
10.1101/2024.11.28.625928 — cancer biology — Posted on 2024-12-03
4691 A combined approach to extract rotational dynamics of globular proteins undergoing liquid-liquid phase separation
Gendreizig, D.; Kalarikkal, A.; Holtbrügge, S. L.; Mukherjee, S.; Galazzo, L.; Kucher, S.; Rosspeintner, A.; Schäfer, L. V.; Bordignon, E.
10.1101/2024.09.17.613388 — biophysics — Posted on 2024-12-03
4692 Mixture of Experts Enable Efficient and Effective Protein Understanding and Design
Sun, N.; Zou, S.; Tao, T.; Mahbub, S.; Li, D.; Zhuang, Y.; Wang, H.; Cheng, X.; Song, L.; Xing, E. P.
10.1101/2024.11.29.625425 — bioinformatics — Posted on 2024-12-03
4696 Immediate perturbation of DNA methylation and transcriptome upon acute prenatal alcohol exposure in the mouse developing brain cortex
DUCHATEAU, A.; CHAPUT, C.; LIVRAMENTO, L.; AUPERIN, N.; MIOZZO, F.; LE MOUEL, A.; KIRSH, O.; MOHAMED, M.; OTT, S.; SABERAN-DJONEIDI, D.; MEZGER, V.
10.1101/2022.03.09.481186 — genomics — Posted on 2024-12-03
4697 Is the nematode Strongyloides stercoralis a zoonosis from dogs? - a population genetics approach.
:iu, Y.; Sarker, R.; Sripa, B.; Tangkawatta, S.; Khieu, V.; Nevin, W.; Paterson, S.; Viney, M.
10.1101/2024.11.29.625877 — genetics — Posted on 2024-12-03
4698 Analysis of lifespan across Diversity Outbred mouse studies identifies multiple longevity-associated loci
Mullis, M. N.; Wright, K. M.; Raj, A.; Gatti, D. M.; Reifsnyder, P.; Flurkey, K.; Archer, J. R.; Robinson, L.; Di Franscesco, A.; Svenson, K. L.; Korstanje, R.; Harrison, D. E.; Ruby, J. G.; Churchill, G. A.
10.1101/2024.11.20.624531 — genetics — Posted on 2024-12-03
4699 Using animal tracking for early detection of mass poisoning events
Curk, T.; Santangeli, A.; Rast, W.; Portas, R.; Shatumbu, G.; Cloete, C.; Beytell, P.; Aschenborn, O.; Melzheimer, J.
10.1101/2024.11.29.625987 — ecology — Posted on 2024-12-03
4701 Selection strengthens the relationship between plant diversity and the metabolic profile of Plantago lanceolata
Medina-van Berkum, P.; De Giorgi, F.; Rothe, B.; Durka, W.; Gershenzon, J.; Roscher, C.; Unsicker, S. B.
10.1101/2024.11.29.626026 — ecology — Posted on 2024-12-03
4702 Impacts of taxonomic change on the Amazonian palm flora
Stropp, J.; Pereira, A. S. S.; Emilio, T.; Meyer, L.; Trad, R.; Alves-Martins, F.; Ladle, R. J.; Hortal, J.
10.1101/2024.11.29.625979 — ecology — Posted on 2024-12-03
4704 NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus
Davies, K.; Rizek, A.-M.; Kollnberger, S.; Wang, E. C. Y.; Eberl, M.; Underwood, J.; McLaren, J.
10.1101/2024.11.29.625999 — immunology — Posted on 2024-12-03
4705 Tracking antigen-specific T cell response to cancer immunotherapy
Shagina, I. A.; Nakonechanaya, T. O.; Izosimova, A. V.; Yuzhakova, D. V.; Skatova, V. D.; Lupyr, K. R.; Izraelson, M.; Davydov, A. N.; Shugay, M.; Britanova, O. V.; Chudakov, D. M.; Sharonov, G. V.
10.1101/2024.11.29.626027 — immunology — Posted on 2024-12-03
4706 Increased NFAT and NFκB signalling contribute to the hyperinflammatory phenotype in response to Aspergillus fumigatus in cystic fibrosis
Bercusson, A.; Williams, T. J.; Simmonds, N. J.; Alton, E. W.; Griesenbach, U.; Shah, A.; Warris, A.; Armstrong-James, D.
10.1101/2024.11.29.625998 — immunology — Posted on 2024-12-03
4708 Proximity to Explosive Synchronization Determines Network Collapse and Recovery Trajectories in Neural and Economic Crises
Lee, U.; Kim, H.; Kim, M.; Oh, G.; Park, A.; Joo, P.; Pal, D.; Tracey, I.; Warnaby, C. E.; Sleigh, J.; Mashour, G. A.
10.1101/2024.11.28.625924 — systems biology — Posted on 2024-12-03
4709 Therapeutic potential of human mesenchymal stromal cell-derived mitochondria in a rat model of post-surgical digestive fistula: towards an energetic nano-biotherapy
Mariani, A.; GUICHARD, A.; Sebbagh, A.; Cronemberger Andrade, A.; Al Amir Dache, Z.; Ribes, C.; Ayollo, D.; Karoui, M.; Lavieu, G.; Gazeau, F.; Silva, A. K. A.; Rahmi, G.; Mozafari, S.
10.1101/2024.11.29.626014 — systems biology — Posted on 2024-12-03
4710 Editing cis-elements of OsPHO1;2 improved phosphate transport and yield in rice
Maurya, K.; Mani, B.; Singh, B.; Sirohi, U.; Jaskolowski, A.; Sharma, S.; Tatiparthi, H. V.; Mangrauthia, S. K.; Pandey, R.; Poirier, Y.; Giri, J.
10.1101/2024.11.28.625858 — plant biology — Posted on 2024-12-03
4712 PlantRing: A high-throughput wearable sensor system for decoding plant growth, water relations and innovating irrigation
Sun, T.; LU, C.; Shi, Z.; Zou, M.; Bi, P.; Xu, X.; Xie, Q.; Jiang, R.; Liu, Y.; Cheng, R.; Xu, W.; Zhang, Y.; Xu, P.
10.1101/2024.11.29.625988 — plant biology — Posted on 2024-12-03
4713 Targeted glycophagy ATG8 therapy for diabetic heart disease
Mellor, K. M.; Varma, U.; Koutsifeli, P.; Curl, C. L.; Janssens, J. V.; Daniels, L. J.; Bernasochi, G.; Raaijmakers, A. J. A.; Annandale, M.; Li, X.; James, S. L.; Taylor, D. J.; Raedschelders, K.; Weeks, K. L.; Mills, R. J.; Parton, R. G.; Hu, X.; Bell, J. R.; Porrello, E. R.; Hudson, J. E.; Xiao, R.-P.; Van Eyk, J. E.; Gottlieb, R. A.; Delbridge, L.
10.1101/2024.11.28.625926 — physiology — Posted on 2024-12-03
4716 Mavacamten facilitates myosin head ON-to-OFF transitions and shortens thin filament length in relaxed skeletal muscle
Kuehn, M. N.; Engels, N. M.; Nissen, D. L.; Freundt, J.; Ma, W.; Irving, T.; Linke, W. A.; Hessel, A. L.
10.1101/2024.11.29.626031 — physiology — Posted on 2024-12-03
4717 microRNA-544a as a new modulator of the Wnt-signalling network in the articular cartilage and osteoarthritis
Heluany, C. S.; Day, N. J.; DeLos Santos, K.; De Palma, A.; Swingler, T. E.; Sochart, D.; Clark, I.; Kapoor, M.; Nalesso, G.
10.1101/2024.11.28.625937 — pharmacology and toxicology — Posted on 2024-12-03
4718 IKZF2-ERBB4 gene fusion leads to ERBB4 overexpression in Anal Squamous Cell Carcinoma but with no benefit for ERBB4 inhibition
RICHON, S.; Schnitzler, A.; Lazartigues, J.; Briaux, A.; Vacher, S.; El Botty, R.; EL-ALAM, E.; Mariani, P.; Neuzillet, C.; LIEVRE, a.; CACHEUX, W.; BIECHE, I.; DANGLES-MARIE, V.
10.1101/2024.11.28.625910 — cancer biology — Posted on 2024-12-03
4719 HIFalpha isoform specific activities drive cell-type specificity of VHL-associated oncogenesis
Lima, J. D. C. C.; Hooker, M.; Li, R.; Barros, A. B.; Masson, N.; Pugh, C. W.; Mole, D. R.; Adam, J.; Ratcliffe, P. J.; Kurlekar, S.
10.1101/2024.11.28.625663 — cancer biology — Posted on 2024-12-03
4721 The DNA Mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression
Brooksbank, K.; Maniati, E.; Tse, W. Y.; Hall, A.; Wang, J.; Sharp, T. V.; Martin, S.
10.1101/2024.11.28.625929 — cancer biology — Posted on 2024-12-03
4723 Optimized Protein-Excipient Interactions in theMartini 3 Force Field
Prass, T. M.; Lindorff-Larsen, K.; Garidel, P.; Blech, M.; Schäfer, L. V.
10.1101/2024.11.29.626008 — biophysics — Posted on 2024-12-03
4724 Deconvolution of omics data in Python with Deconomix -- cellular compositions, cell-type specific gene regulation, and background contributions
Altenbuchinger, M. C.; Mensching-Buhr, M.; Sterr, T.; Seifert, N.; Voelkl, D.; Tauschke, J.; Rayford, A.; Zacharias, H. U.; Grellscheid, S. N.; Beissbarth, T.; Goertler, F.
10.1101/2024.11.28.625894 — bioinformatics — Posted on 2024-12-03
4726 Scaling Dense Representations for Single Cell with Transcriptome-Scale Context
Ho, N.; Ellington, C. N.; Hou, J.; Addagudi, S.; Mo, S.; Tao, T.; Li, D.; Zhuang, Y.; Wang, H.; Cheng, X.; Song, L.; Xing, E. P.
10.1101/2024.11.28.625303 — bioinformatics — Posted on 2024-12-03
4728 gplasCC: classification and reconstruction of plasmids from short-read sequencing data for any bacterial species
Paganini, J. A.; Kerkvliet, J. J.; Jordan, O.; Teunis, G.; Plantinga, N. L.; Willems, R. J. L.; Arredondo-Alonso, S.; Schurch, A. C.
10.1101/2024.11.28.625923 — bioinformatics — Posted on 2024-12-03
4731 Sub-cellular Imaging of the Entire Protein-Coding Human Transcriptome (18933-plex) on FFPE Tissue Using Spatial Molecular Imaging
Khafizov, R.; Piazza, E.; Cui, Y.; Patrick, M.; Metzger, E.; McGuire, D.; Dunaway, D.; Danaher, P.; Hoang, M. L.; Grootsky, A.; Vandenberg, M.; He, S.; Liu, R.; McKean, M.; Rhodes, M.; Beechem, J. M.
10.1101/2024.11.27.625536 — genomics — Posted on 2024-12-03
4732 A unified model of gene expression control by cohesin and CTCF
Choudhary, C.; Narita, T.; Higashijima, Y.; Kilic, S.; Pappas, G.; Maskey, E.
10.1101/2024.11.29.625887 — genomics — Posted on 2024-12-03
4736 Predicting woodland bird species habitat with multi-temporal and multisensor remote sensing data
Kuzmich, R. J.; Hill, R. A.; Hinsley, S. A.; Bellamy, P. E.; Barnes, A. E.; Melin, M.; Treitz, P. M.
10.1101/2024.11.28.625964 — ecology — Posted on 2024-12-03
4738 Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis
Li, J.; Wang, X.; Jordana, L.; Bonneil, E.; Ginestet, V.; Ahmed, M.; Bourouh, M.; Pascariu, C. M.; Schmeing, M.; Thibault, P.; Archambault, V.
10.1101/2024.10.07.617051 — cell biology — Posted on 2024-12-03
4739 The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine
Crawford, M. W.; Abdelwahab, W. M.; Siram, K.; Parkins, C. J.; Harrison, H. F.; Osman, S. R.; Schweitzer, D.; Evans, J. T.; Burkhart, D. J.; Pinto, A. K.; Brien, J. D.; Smith, J. L.; Hirsch, A. J.
10.1101/2024.11.28.625832 — immunology — Posted on 2024-12-03
4741 ST6GAL1-mediated sialyl linkage switching in tumor-associated macrophages drives cancer-promoting nanotubes carrying α2,6-sialylation in anti-inflammatory cells
Dipta, P.; Bansal, N.; Sumer-Bayraktar, Z.; Chien, A.; Ugonotti, J.; Chau, T. H.; Anugraham, M.; Kolarich, D.; Tirosh, B.; Kawahara, R.; Thaysen-Andersen, M.
10.1101/2024.11.28.625934 — immunology — Posted on 2024-12-03
4744 Toward Holistic Solutions to Undernutrition: A Comprehensive Preclinical Protocol for Novel Ready-to-Use Therapeutic Foods Testing
Utume, L.; Janssen, J. N.; Akomo, P.; Shaw, D.; Edwards, W. J. S.; Muleya, M.; Nikolaou, C. K.; Schneider, A.; Westby, A.; Reifen, R.; Tsaousis, A. D.; Monsonego-Ornan, E.; Benchoff, A.
10.1101/2024.11.28.625813 — physiology — Posted on 2024-12-03
4747 Isolation and characterization of microbiota from human pancreatic tumors and small intestine
Awad, D.; Attebury, H.; Hong, R.; Kim, K.; Zhang, L.; Bischoff, A.; deDekker, A.; Hoostal, M.; Nieto Carrion, J. A.; Nelson, N. S.; Strayhorn, C.; Frankel, T.; Pasca di Magliano, M.; Lyssiotis, C. A.; Schmidt, T. M.; Daley, D.
10.1101/2024.11.27.625762 — cancer biology — Posted on 2024-12-03
4755 State-specific Peptide Design Targeting G Protein-coupled Receptors
Xue, Y.; Li, J.; Wang, H.; Hu, J.; Zheng, Z.; He, J.; Gong, H.; Li, X.; Zhang, X.; Fang, X.
10.1101/2024.11.27.625792 — bioinformatics — Posted on 2024-12-03
4757 AlphaPulldown2 - A General Pipeline for High-Throughput Structural Modeling
Molodenskiy, D.; Maurer, V.; Yu, D.; Chojnowski, G.; Bienert, S.; Tauriello, G.; Gilep, K.; Schwede, T.; Kosinski, J.
10.1101/2024.11.28.625873 — bioinformatics — Posted on 2024-12-03
4758 ReSCU-Nets: recurrent U-Nets for segmentation of multidimensional microscopy data
Hawkins, R.; Balaghi, N.; Rothenberg, K. E.; Ly, M.; Fernandez-Gonzalez, R.
10.1101/2024.11.28.625889 — bioinformatics — Posted on 2024-12-03
4760 Development of a Novel Hybprinter-SAM for Functionally Graded Tissue Engineering Constructs with Patterned and Localized Biochemical Signals
Li, J.; Kim, C.; Alizadeh, H. V.; Garg, S.; Bruyas, A.; Zhao, P.; Passos, I. S. D.; Flores Perez, A. S.; Yang, Y. P.
10.1101/2024.11.27.620700 — bioengineering — Posted on 2024-12-03
4766 Broadscale reconnaissance of coral reefs from citizen science and deep learning
Lawson, C. L.; Chartrand, K. M.; Roelfsema, C. M.; Kolluru, A.; Mumby, P. J.
10.1101/2024.11.27.625580 — ecology — Posted on 2024-12-03
4767 Kinetic patterns of single cell gene expression discriminate between the murine cellular responses to live attenuated and inactivated Yellow Fever vaccines
Chatterjee, B.; Boughter, C. T.; Gorga, K.; Ohta, Y.; Blair, C.; Hill, E. M.; Fasana, Z.; Atuheirwe, M.; Adebamowo, A.; Ammar, F.; Ayithan, N.; Courneya, J.; Kosik, I.; Murugan, V.; Chen, W. H.; Pasetti, M. F.; Meier-Schellersheim, M.; Singh, N. J.
10.1101/2024.11.26.625490 — immunology — Posted on 2024-12-03
4768 Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states
Babdor, J.; Patel, R. K.; Davidson, B.; Noecker, C.; Rahim, M.; Bisanz, J. E.; Tenvooren, I.; Marquez, D.; Calvo, M.; Johri, V.; McCarthy, E.; Shaheed, A.; Ekstrand, C.; Weakley, A. M.; Yu, F. B.; Fiehn, O.; Turnbaugh, P. J.; Combes, A. J.; Fragiadakis, G. K.; Spitzer, M. H.
10.1101/2024.11.27.625750 — immunology — Posted on 2024-12-03
4769 Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies
Lederhofer, J.; Borst, A. J.; Nguyen, L.; Gillespie, R. A.; Williams, C. J.; Walker, E. L.; Raab, J. E.; Yap, C.; Ellis, D.; Creanga, A.; Tan, H.-X.; Du, T. H. T.; Ravichandran, M.; McDermott, A. B.; Le Sage, V.; Andrews, S. F.; Graham, B. S.; Wheatley, A. K.; Reed, D. S.; King, N. P.; Kanekiyo, M.
10.1101/2024.11.27.625426 — immunology — Posted on 2024-12-03
4770 Potential antiviral and immunomodulatory Amazonian medicinal plant compounds
Napoleao, S. M. d. S.; Bernardes, J. P. R. A.; Tenorio, B. G.; Cardenas, C. M.; Dallago, B. S. L.; Cicek, S. S.; Bezzerra, R. M.; Segovia, J. F. O.; Kanzaki, E. C. G. d. M.; Kanzaki, I.
10.1101/2024.11.27.625749 — immunology — Posted on 2024-12-03
4775 Polyfunctional IL-21+ IFNg+ T follicular helper cells contribute to checkpoint inhibitor diabetes mellitus and can be targeted by JAK inhibitor therapy
Huang, N.; Ortega, J.; Kimbrell, K.; Lee, J.; Scott, L. N.; Peluso, E. M.; Wang, S. J.; Kao, E.; Kim, K.; Olay, J.; Quandt, Z.; Angell, T. E.; Su, M. A.; Lechner, M. G.
10.1101/2024.11.27.625710 — immunology — Posted on 2024-12-03
4777 Modulating activity of the APC/C regulator SlSAMBA improves the sugar and antioxidant content of tomato fruits
de Oliveira, P. N.; de Souza, L. P.; Ferreira, P. B.; Mauxion, J.-P.; Correa-Silva, L. F.; Chang, A. I.; Saleme, M. d. L. S.; Selma, S.; De Beukelaer, H.; Martins, M. C. M.; Pino, L. E.; Bollier, N.; Peres, L. E. P.; Vandepoele, K.; Goossens, A.; Gonzalez, N.; Fernie, A. R.; Eloy, N. B.
10.1101/2024.11.27.625495 — plant biology — Posted on 2024-12-03
4778 Exploring the Impact of Apocarotenoids on Pathogenic Fusarium oxysporum f.sp. lini and Endophytic Fo47 strains
Kochneva, Y.; Burgberger- Stawarz, M.; Boba, A.; Preisner, M.; Mierziak- Derecka, J.; Kulma, A.
10.1101/2024.11.28.625830 — physiology — Posted on 2024-12-03
4779 Early exposure to Western diet exacerbates visual outcomes in female mice.
Meseguer, D.; Furtado, J.; Zapadka, T.; Rodriguez, A.; Na, D.; Grajales, J.; Demb, J.; Eichmann, A. E.; Schneeberger, M.
10.1101/2024.11.27.625688 — physiology — Posted on 2024-12-03
4780 Sex specific effects of environmental toxin-derived alpha synuclein on enteric neuronal-epithelial interactions
Templeton, H. N.; Ehrlich, A. T.; Schwerdtfeger, L. A.; Sheng, J. A.; Tjalkens, R. B.; Tobet, S. A.
10.1101/2024.11.27.625701 — physiology — Posted on 2024-12-03
4781 Neutrophils drive sexual dimorphism in experimental periodontitis
Martin, K.; Mianecki, M.; Maglaras, V.; Sheikh, A.; Saleh, M. H. A.; Decker, A. M.; Decker, J. T.
10.1101/2024.11.27.625678 — pathology — Posted on 2024-12-03
4783 In Situ Integration of Porous Polyethylene Nanomembrane with Wound Exudates for Scarless Healing
Yuan, S.; Gu, Q.; Guo, X.; Tang, X.; Qiu, J.; Shang, L.; Lin, J. Q.; Weng, L.-t.; Gao, P.
10.1101/2024.11.19.624279 — bioengineering — Posted on 2024-12-03
4785 A multistate capture-recapture model to estimate reproduction of North Atlantic right whales
Linden, D. W.; Pace, R. M.; Garrison, L. P.; Hostetler, J. A.; Knowlton, A. R.; Lesage, V.; Williams, R.; Runge, M. C.
10.1101/2024.04.13.589367 — ecology — Posted on 2024-12-03
4789 De novo designed pMHC binders facilitate T cell induced killing of cancer cells
Johansen, K. H.; Wolff, D.; Scapolo, B.; Fernandez-Quintero, M. L.; Christensen, C. R.; Loeffler, J. R.; Rivera-de-Torre, E.; Overath, M. D.; Munk, K. K.; Morell, O.; Viuff, M. C.; Damm Englund, A. T.; Due, M.; Forli, S.; Qingjie Andersen, E.; Fernandes, J. S.; Thumtecho, S.; Ward, A. B.; Ormhoj, M.; Hadrup, S. R.; Jenkins, T. P.
10.1101/2024.11.27.624796 — immunology — Posted on 2024-12-03
4792 Light quantity impacts early response to cold and cold acclimation in young leaves of Arabidopsis
Luklova, M.; Dubois, M.; Kameniarova, M.; Plackova, K.; Novak, J.; Kopecka, R.; Karady, M.; Pavlu, J.; Skalak, J.; Jindal, S.; Tubic, L.; Quddos, Z.; Novak, O.; Inze, D.; Cerny, M.
10.1101/2024.11.27.625718 — plant biology — Posted on 2024-12-03
4793 Sex-specific thermoregulatory effects of estrogen signaling in Reprimo lineage cells
Park, J. W.; Cortes, L. R.; Sandoval, N. P.; Baron, A. G.; Vree, A. R.; Fideles, H. J.; Hansen, M. R.; Lopez, J. I.; Dilday, E. A.; Rashid, S.; Kammel, L. G.; van Veen, J. E.; Correa, S. M.
10.1101/2024.12.02.626488 — physiology — Posted on 2024-12-03
4794 The human glucocorticoid receptor variant rs6190 promotes blood cholesterol and atherosclerosis
Durumutla, H. B.; Haller, A.; Noble, G.; Prabakaran, A. D.; McFarland, K.; Latimer, H.; Akinborewa, O.; Khales, B. N.; Hui, D. Y.; Quattrocelli, M.
10.1101/2024.11.27.625727 — physiology — Posted on 2024-12-03
4796 The fungal protein Jps1 facilitates unconventional protein secretion through a direct phosphoinositide interaction
Dali, S.; Schultz, M.; Koester, M.; Kamel, M.; Busch, M.; Steinchen, W.; Haensch, S.; Papadopoulos, A.; Reiners, J.; Smits, S.; Kedrov, A.; Altegoer, F.; Schipper, K.
10.1101/2024.02.29.582524 — biochemistry — Posted on 2024-12-03
4799 Evolution of temperature preference behaviour among drosophilids
Kafle, T.; Grub, M.; Sakagiannis, P.; Nawrot, M. P.; Arguello, J. R.
10.1101/2024.03.15.585210 — evolutionary biology — Posted on 2024-12-03
4802 TET knockout cells transit between pluripotent states and exhibit precocious germline entry
Chambers, I.; Pantier, R.; Barbieri, E.; Gonzalez Brito, S.; Thomson, E.; Tatar, T.; Colby, D.; Zhang, M.
10.1101/2024.12.02.626356 — developmental biology — Posted on 2024-12-03
4807 Metatranscriptomics-based metabolic modeling of patient-specific urinary microbiome during infection
Josephs-Spaulding, J.; Rettig, H. C.; Zimmermann, J.; Chkonia, M.; Mischnik, A.; Franzenburg, S.; Graspeuntner, S.; Rupp, J.; Kaleta, C.
10.1101/2024.03.25.586446 — systems biology — Posted on 2024-12-03
4811 Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism
Kavanagh, M. E.; McLean, K. J.; Gilbert, S. H.; Amadi, C.; Snee, M.; Tunnicliffe, R. B.; Arora, K.; Boshoff, H.; Fanourakis, A.; Rebello-Lopez, M. J.; Ortega-Muro, F.; Levy, C.; Munro, A. W.; Leys, D.; Abell, C.; Coyne, A. G.
10.1101/2024.10.28.620643 — pharmacology and toxicology — Posted on 2024-12-03
4812 An oncoembryology approach uncovers SoxC-driven regulation of colon development and cancer
Dalessi, T.; Valenta, T.; Moro, G.; Brügger, M. D.; Meijs, A.; Szczerba, B. M.; Brunner, T.; Lampart, S.; Nater, M.; Platt, R. J.; Scharl, M.; van den Broek, M.; Arnold, I. C.; Fazilaty, H.
10.1101/2024.10.08.617191 — cancer biology — Posted on 2024-12-03
4813 Improving Inverse Folding models at Protein Stability Prediction without additional Training or Data
Dutton, O.; Bottaro, S.; Invernizzi, M.; Redl, I.; Chung, A.; Hoffmann, F.; Henderson, L.; Ruschetta, S.; Airoldi, F.; Owens, B. M.; Foerch, P.; Fisicaro, C.; Tamiola, K.
10.1101/2024.06.15.599145 — biophysics — Posted on 2024-12-03
4817 Characteristics of ectopic alveolar basal cells relative to airway basal cells in fibrosis
Blumer, S.; Khan, P.; Roux, J.; Artysh, N.; Plappert, L.; Prasse, A.; Hostettler, K. E.
10.1101/2024.09.24.614660 — cell biology — Posted on 2024-12-03
4819 Amyloid Beta Precursor Protein contributes to brain aging and learning decline in short-lived turquoise killifish (Nothobranchius furzeri)
de Bakker, D. E. M.; Mihaljevic, M.; Gharat, K.; Richter, J.; Bagnoli, S.; van Bebber, F.; Adam, L.; Shamim-Schulze, F.; Ohlenschlaeger, O.; Bens, M.; Cirri, E.; Antebi, A.; Matic, I.; Schneider, A.; Schmid, B.; Cellerino, A.; Kirstein, J.; Valenzano, D. R.
10.1101/2024.10.11.617841 — neuroscience — Posted on 2024-12-03
4821 xTrimoPGLM: Unified 100B-Scale Pre-trained Transformer for Deciphering the Language of Protein
Chen, B.; Cheng, X.; Li, P.; Gengyang, L.-a.; Gong, J.; Li, S.; Bei, Z.; Tan, X.; Wang, B.; Zeng, X.; Liu, C.; Zeng, A.; Dong, Y.; Tang, J.; Song, L.
10.1101/2023.07.05.547496 — synthetic biology — Posted on 2024-12-03
4823 Functional, Biotinylproteomic and Bioinformatic Analysis of Both Cytoskeletal and Plastoskeletal Proteins in Plant Mechanoresponse
WU, K.; Yang, N.; REN, J.; LIU, S.; WANG, K.; DAI, S.; LU, Y.; AN, Y.; TIAN, F.; Gao, Z.; YANG, Z.; ZHANG, Y.; Yu, W.; LI, N.
10.1101/2024.11.30.626153 — plant biology — Posted on 2024-12-03
4826 Deep-learning-enabled generative prevalent mutation prediction through host-to-herd in silico virus evolution
Liu, X.; Nie, Z.; Si, H.; Shen, X.; Liu, Y.; Huang, X.; Dong, T.; Xu, F.; Chen, J.; Zhou, P.; Tian, Y.
10.1101/2024.11.28.625962 — evolutionary biology — Posted on 2024-12-03
4827 B cells imprinted by ancestral SARS-CoV-2 develop pan-sarbecovirus neutralization in immune recalls
Chen, X.; Li, L.; Du, R.; Wang, Z.; Li, Y.; Sun, Y.; Qin, R.; Feng, H.; Hu, L.; Chen, X.; Lu, M.; Huang, X.; Jiang, L.; Zuo, T.
10.1101/2024.10.13.618110 — immunology — Posted on 2024-12-03
4828 Translocation of effector proteins into plant cells by the flax rust pathogen Melampsora lini
Zhang, X.; Catanzariti, A.-M.; Lawrence, G. J.; Gan, P. H. P.; Jones, D. A.; Dodds, P. N.; Rathjen, J. P.
10.1101/2024.12.01.625101 — plant biology — Posted on 2024-12-03
4829 Spatiochemical Investigation of Potential Biocontrol Agents Against Phytophthora capsici Infection in Tomato
Robinson, J. Y.; Shepard, H. S.; Ambachew, D.; Eyegheleme, P. J.; May, J. C.; Mmbaga, M.; McLean, J. A.
10.1101/2024.12.02.626494 — plant biology — Posted on 2024-12-03
4831 Rhizobium rhizogenes A4-derived strains mediate hyper-efficient transient gene expression in Nicotiana benthamiana and other solanaceous plants
Lopez-Agudelo, J. C.; Goh, F.-J.; Tchabashvili, S.; Huang, Y.-S.; Huang, C.-Y.; Lee, K.-T.; Wang, Y.-C.; Wu, Y.; Chang, H.-X.; Kuo, C.-H.; Lai, E.-M.; Wu, C.-H.
10.1101/2024.11.30.626145 — plant biology — Posted on 2024-12-03
4832 Molecular evolution of a reproductive barrier in maize and related species
Cryan, E.; Phinney, G.; Seetharam, A. S.; Evans, M. M. S.; Kellogg, E. A.; Zhan, J.; Meyers, B. C.; Kliebenstein, D.; Ross-Ibarra, J.
10.1101/2024.12.02.626474 — genetics — Posted on 2024-12-03
4837 The complete genome sequence of the crayfish pathogen Candidatus Paracoxiella cheracis n.g. n.sp. provides insight into pathogenesis and the phylogeny of the Coxiellaceae family
Ingle, D. J.; Walsh, C.; Samuel, G. R. M.; Wick, R. R.; Davidovic, N.; Fiocchi, E.; Judd, L. M.; Elliman, J.; Owens, L.; Stinear, T. P.; Basso, A.; Pretto, T.; Newton, H. J.
10.1101/2024.12.02.626477 — microbiology — Posted on 2024-12-02
4839 The Regulation of MAGI2 and its Diagnostic Application in Podocytopathies
Siegerist, F.; Hay, E.; Hammer, E.; Iervolino, A.; Weber, C.; Dikou, J. S.; Stamellou, E.; Butt, L.; Benzing, T.; Wiech, T.; Brinkkoetter, P.; Zimmermann, U.; Capasso, G.; Chatziantoniou, C.; Chadjichristos, C.; Huber, T. B.; Voelker, U.; Schindler, M.; Endlich, N.
10.1101/2024.12.01.626009 — cell biology — Posted on 2024-12-02
4841 BECLIN-1 is Essential for the Maintenance of Gastrointestinal Epithelial Integrity by Regulating Endocytic Trafficking, F-actin Organization and Lysosomal Function
Juliani, J.; Tran, S.; Harris, T. J.; De Cruz, P.; Ellis, S. L.; Gleeson, P. A.; Mariadason, J. M.; Duszyc, K.; Yap, A. S.; Lee, E. F.; Fairlie, W. D.
10.1101/2024.11.28.625769 — cell biology — Posted on 2024-12-02
4842 Control of Epithelial Tissue Organization by mRNA Localization
Mason, D. E.; Madsen, T. D.; Gasparski, A. N.; Jiwnani, N.; Lechler, T.; Weigert, R.; Iglesias-Bartolome, R.; Mili, S.
10.1101/2024.12.02.626432 — cell biology — Posted on 2024-12-02
4844 Single cell migration along and against confined haptotactic gradients
Fortunato, I. C.; Brückner, D. B.; Grosser, S.; Rossetti, L.; Bosch-Padros, M.; Trebicka, J.; Roca-Cusachs, P.; Sunyer, R.; Hannezo, E.; Trepat, X.
10.1101/2024.12.02.626413 — cell biology — Posted on 2024-12-02
4845 Polycomb Repressive Complex 2 promotes atherosclerotic plaque vulnerability
Joshi, D.; Chakraborty, R.; Bhogale, T.; Furtado, J.; Deng, H.; Traylor, J. G.; Orr, A. W.; Martin, K. A.; Schwartz, M. A.
10.1101/2024.12.02.626505 — cell biology — Posted on 2024-12-02
4847 The Immunoregulatory Architecture of the Adult Oral Cavity
Fernandes Matuck, B.; Huynh, K.; Pereira, D.; Zhang, X.; Kunz, M.; Kumar, N.; Easter, Q. T.; Fernandes, A.; Ghodke, A.; Predeus, A.; Szabo, L.; Harnischfeger, N.; Khavandgar, Z.; Beach, M.; Perez, P.; Nilges, B.; Moreno, M.; Ko, K.; Teichmann, S.; Kimple, A.; Pringle, S.; kretzschmar, K.; Warner, B. M.; Sequeira, I.; Liu, J.; Byrd, K. M.
10.1101/2024.12.01.626279 — cell biology — Posted on 2024-12-02
4848 Industrialization of three-dimensional hiPSC-cardiac microtissues for high-throughput cardiac safety and drug discovery screening
de Korte, T.; Johnson, B. B.; Kosmidis, G.; Samson-Couterie, B.; Mol, M. P. H.; van Helden, R. W. J.; Francois, L.; Meraviglia, V.; Yiangou, L.; Kuipers, T. B.; Mei, H.; Bellin, M.; Braam, S. R.; Jain, S.; Mummery, C.; Davis, R. P.
10.1101/2024.11.29.626032 — cell biology — Posted on 2024-12-02
4850 Importin α accumulates in micronuclei and associates with genomic instability in human cancer cells
Miyamoto, Y.; Kisanuki, R.; Oshima, R.; Yoshimura, S. H.; Yokota, M.; Maehara, K.; Hata, C.; Tachibana, T.; Koike, M.; Ohkawa, Y.; Katagiri, T.; Yoneda, Y.; Oka, M.; Saitoh, H.
10.1101/2023.06.06.543979 — cell biology — Posted on 2024-12-02
4851 Heat-Induced Phosphatidylserine Changes Drive HSPA1A's Plasma Membrane Localization
Low, J.; Altman, R.; Badolian, A.; Cuaresma, A. B.; Briseno, C.; Keshet, U.; Fiehn, O.; Stahelin, R. V.; Nikolaidis, N.
10.1101/2024.12.02.626454 — cell biology — Posted on 2024-12-02
4853 Molecular Correlates of Glycine Receptor Activity in Human β Cells
Gomes, A. S.; Ellis, C. E.; Spigelman, A. F.; dos Santos, T.; Maghera, J.; Suzuki, K.; MacDonald, P. E.
10.1101/2024.12.02.626463 — cell biology — Posted on 2024-12-02
4857 Genetic Control of Prickles in Tetraploid Blackberry
Johns, C. A.; Silva, A.; Chizk, T. M.; Nelson, L.; Clark, J. R.; Aryal, R.; Ashrafi, H.; Thompson, E.; Hardigan, M. A.; Worthington, M. L.
10.1101/2024.11.27.625708 — genetics — Posted on 2024-12-02
4861 Drug screening targeting TREM2-TYROBP transmembrane binding
Cobas-Carreno, M.; Esteban-Martos, A.; Tomas-Gallardo, L.; Iribarren, I.; Gonzalez-Palma, L.; Rivera-Ramos, A.; Guerra, J. E.; Alarcon-Martin, E.; Ruiz, R.; Bravo, M. J.; Venero, J. L.; Morato, X.; Ruiz, A.; Royo, J. L.
10.1101/2024.12.02.626344 — molecular biology — Posted on 2024-12-02
4862 Early prediction of preeclampsia using the first trimester vaginal microbiome
Kindschuh, W. F.; Austin, G. I.; Meydan, Y.; Park, H.; Urban, J. A.; Watters, E.; Pollak, S.; Saade, G. R.; Chung, J.; Mercer, B. M.; Grobman, W. A.; Haas, D. M.; Silver, R. M.; Serrano, M.; Buck, G. A.; McNeil, R.; Nandakumar, R.; Reddy, U.; Wapner, R. J.; Brown Kav, A.; Uhlemann, A.-C.; Korem, T.
10.1101/2024.12.01.626267 — microbiology — Posted on 2024-12-02
4863 KlebPhaCol: A community-driven resource for Klebsiella research identified a novel gut phage order associated with the human gut
Rothschild-Rodriguez, D.; Lambon, K. S.; Latka, A.; Costa, A. R.; Mantzouratou, A.; King, C.; Boeckaerts, D.; Sheridan, E.; Merrick, F.; Drobniewski, F.; De Angelis, I.; Saeed, K.; Sutton, J. M.; Wand, M. E.; Andrew, M.; Hedges, M.; Brouns, S. J. J.; Haas, P.-J.; Kushwaha, S. K.; Lawson, S. T.; Fordham, S. M. E.; Lee, Y.-J.; Wu, Y.; Briers, Y.; Weigele, P. R.; Nobrega, F. L.
10.1101/2024.12.02.626457 — microbiology — Posted on 2024-12-02
4864 Distinct roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages
Khan, I.; MacDonald, S. J.; Markusson, S.; Robson, C.; Parker, J. L.; Newstead, S.; Boucher, D.; Van der Woude, M.; Thomas, G. H.
10.1101/2024.12.02.626324 — microbiology — Posted on 2024-12-02
4865 Modest functional diversity decline and pronounced composition shifts of microbial communities in a uranium-contaminated aquifer
Fan, Y.; Wang, D.; Yang, J. X.; Ning, D.; He, Z.; Zhang, P.; Rocha, A. M.; Xiao, N.; Michael, J. P.; Walker, K. F.; Joyner, D. C.; Pan, C.; Adams, M.; Fields, M.; Alm, E. J.; Stahl, D.; Hazen, T. C.; Adams, P. D.; Arkin, A. P.; Zhou, J.
10.1101/2024.12.02.626466 — microbiology — Posted on 2024-12-02
4866 The complete genome sequence of the crayfish pathogen Candidatus Paracoxiella cheracis n.g. n.sp. provides insight into pathogenesis and the phylogeny of the Coxiellaceae family
Ingle, D. J.; Walsh, C.; Samuel, G. R. M.; Wick, R. R.; Davidovic, N.; Fiocchi, E.; Judd, L. M.; Elliman, J.; Owens, L.; Stinear, T. P.; Basso, A.; Pretto, T.; Newton, H. J.
10.1101/2024.12.02.626477 — microbiology — Posted on 2024-12-02
4868 Whole genome Sequencing Reveals Enterobacter hormaechei as a key Bloodstream Pathogen in six tertiary care hospitals in southwestern Nigeria.
Oni, F. I.; Afolayan, A. O.; Oaikhena, A. O.; Odih, E. E.; Ikhimiukor, O. O.; Ogunleye, V. O.; Aboderin, A. O.; Olabisi, O. F.; Amupitan, A. A.; Fadeyi, A.; Raheem, R.; Olanipekun, B. A.; Elikwu, C. J.; Sadare, O.; Oshun, P. O.; Oduyebo, O. O.; Ojo, F.; Adeyemo, A. T.; Mba, I. E.; Egwuenu, A.; Okwor, T. J.; Underwood, A.; Argimon, S.; Ihekweazu, C.; Aanensen, D. M.; Okeke, I. N.
10.1101/2024.12.02.626058 — microbiology — Posted on 2024-12-02
4869 Expanding the CarD interaction network: CrsL is a novel transcription factor in Mycobacterium smegmatis
Shoman, M.; Jirat Matejckova, J.; Schwarz, M.; Cerny, M.; Borah, N.; Vankova Hausnerova, V.; Sikova, M.; Sanderova, H.; Halada, P.; Hubalek, M.; Dvorakova, V.; Prevorovsky, M.; Holubova, J.; Stanek, O.; Krasny, L.; Zidek, L.; Hnilicova, J.
10.1101/2024.12.02.626298 — microbiology — Posted on 2024-12-02
4871 Distinct metabolic profiles of circulating plasmacytoid dendritic cells in systemic sclerosis patients stratified by clinical phenotypes
Ferreira, B. H.; Mazeda, C.; Dourado, E.; Simoes, J. L.; Prata, A. R.; ARGUELLO, R. J.; Duarte, I. F.; Pierre, P.; Almeida, C. R.
10.1101/2024.11.27.625448 — immunology — Posted on 2024-12-02
4872 L-Asparaginase treatment induces reversible immunoregulatory and immunosuppressive effects in non-malignant B cells in a model of T-cell dependent B cell activation
Hadzic, A.; Garcia-Marquez, M. A.; Bannasch, P.; Haindl, N.; Frey, K.; Kirmaier, M.; Funk, M. A.; Tischmacher, A.; Tu, J.; Carboniero, A.; Vona, L.; Oganesian, S.; Cordas dos Santos, D. M.; Schloesser, H.; von Bergwelt-Baildon, M.; Schmitz, W.; Theurich, S.
10.1101/2024.11.27.625617 — immunology — Posted on 2024-12-02
4875 Direct high-throughput deconvolution of unnatural bases via nanopore sequencing and bootstrapped learning
Perez, M.; Kimoto, M.; Rajakumar, P.; Suphavilai, C.; Peres da Silva, R.; Pen Tan, H.; Ting Xun Ong, N.; Nicholas, H.; Hirao, I.; Wei Leong, C.; Nagarajan, N.
10.1101/2024.12.02.625113 — synthetic biology — Posted on 2024-12-02
4877 Targeting Endoplasmic Reticulum Stress and Nitroso-Redox Imbalance in Neuroendocrine Prostate Cancer: The Therapeutic Role of Nitric Oxide
FIRDAUS, F.; Companioni Napoles, O.; QURESHI, R.; Dulce, R. A.; Edupuganti, A.; Kumar, S.; Shah, K.; Salihoglu, S.; Van Booven, D. A.; Gasca, R.; Punnen, S.; Lombard, D.; Hare, J. M.; ARORA, H.
10.1101/2024.11.27.624202 — cancer biology — Posted on 2024-12-02
4878 Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation
Hernandez, G. G.; Martins, M. L.; Fernandes, N. P.; Veloso, T.; Lopes, J.; Gomes, T.; Cordeiro, T.
10.1101/2024.12.02.626213 — biophysics — Posted on 2024-12-02
4879 Advanced Peptide Nanoparticles Enable Robust and Efficient delivery of gene editors across cell types
Gustafsson, O.; Krishna, S.; Borate, S.; Ghaeidamini, M.; Liang, X.; Saher, O.; Cuellar, R.; Birdsong, B. K.; Roudi, S.; Estupinan, Y. H.; Alici, E.; Smith, E. C.; Esbjörner, E. K.; Spuler, S. K.; de Jong, O. G.; Escobar, H.; Nordin, J. Z.; Andaloussi, S. E.
10.1101/2024.11.27.624305 — bioengineering — Posted on 2024-12-02
4882 The molecular basis of integrated stress response silencing
Yang, Z.; Haakonsen, D.; Heider, M.; Witus, S. R.; Zelter, A.; Beschauner, T.; MacCoss, M. J.; Rape, M.
10.1101/2024.12.02.626349 — biochemistry — Posted on 2024-12-02
4883 Identification of Inhibitors of Chikungunya virus nsP2 ATPase
Navarro, H.; Scott, J. E.; Smith, G. R.; Ghiabi, P.; Gibson, E.; Loppnau, P.; Harding, R. J.; Hossain, M. A.; Bose, M. R.; Pearce, K. H.; Merten, E. M.; Willson, T. M.; Brown, P. J.
10.1101/2024.12.02.625520 — biochemistry — Posted on 2024-12-02
4884 Roots of coastal plants stabilize carbon fixed by marine algae
Hellige, I.; Mundanatt, A. A.; Massing, J. C.; Hehemann, J.-H.
10.1101/2024.12.02.624615 — biochemistry — Posted on 2024-12-02
4885 Functional constraints of wtf killer meiotic drivers
Srinivasa, A. N.; Campbell, S.; Venkatesan, S.; Nuckolls, N. L.; Lange, J. J.; Halfmann, R.; Zanders, S. E.
10.1101/2024.08.27.609905 — genetics — Posted on 2024-12-02
4886 Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration
Hahn, H.; Daly, C.; Little, J.; Perry-Hauser, N. A.; Flores-Espinoza, E.; Inoue, A.; Plouffe, B.; Thomsen, A. R. B.
10.1101/2022.09.27.509755 — cell biology — Posted on 2024-12-02
4887 Investigating the potential role of capsaicin in facilitating the spread of coxsackievirus B3 via extracellular vesicles
Chatterjee, S.; Tilley, H.; Briordy, D.; Waldron, R. T.; Kordbacheh, R.; Cutts, W. D.; Cook, A.; Pandol, S. J.; Kim, B.; Fairweather, D.; Sin, J.
10.1101/2024.12.02.626352 — microbiology — Posted on 2024-12-02
4889 Mapping the canine microbiome: Insights from the Dog Aging Project
Bamberger, T.; Muller, E.; Algavi, Y. M.; Greenier, A.; Adjangba, C.; Slikas, E.; Brassington, L.; Mariner, B.; McCoy, B.; Harrison, B. R.; Partida-Aguilar, M.; Marye, A.; Harris, A.; Rout, E.; DAP Consortium, ; Avery, A.; Promislow, D. E. L.; Snyder-Mackler, N.; Borenstein, E.
10.1101/2024.12.02.625632 — microbiology — Posted on 2024-12-02
4891 A signal of temporal integration in the human auditory brain: psychological insights, EEG evidence, and clinical application
Xu, H.; Huang, Q.; Song, P.; Zhai, Y.; Du, X.; Ye, H.; Bao, X.; Mehmood, I.; Tanigawa, H.; Niu, W.; Tu, Z.; Chen, P.; Zhang, T.; Zhang, L.; Zhao, X.; Wen, W.; Cao, L.; Yu, X.
10.1101/2024.12.02.626219 — neuroscience — Posted on 2024-12-02
4893 A signal of temporal integration in the human auditory brain: psychological insights, EEG evidence, and clinical application
Xu, H.; Huang, Q.; Song, P.; Zhai, Y.; Du, X.; Ye, H.; Bao, X.; Mehmood, I.; Tanigawa, H.; Niu, W.; Tu, Z.; Chen, P.; Zhang, T.; Zhang, L.; Zhao, X.; Wen, W.; Cao, L.; Yu, X.
10.1101/2024.12.02.626219 — neuroscience — Posted on 2024-12-02
4898 RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS
Naumann, M.; Kretschmar, S.; Dash, B. P.; Peikert, K.; Glass, H.; Grossmann, D.; Guenther, R.; Petri, S.; Roediger, A.; Brenner, D.; Pan-Montojo, F.; Aronica, E.; Kipp, M.; Zimyanin, V.; Sterneckert, J.; Grehl, T.; Boeckers, T.; Oeckl, P.; Lee-Kirsch, M. A.; Hermann, A.
10.1101/2024.12.02.626340 — neuroscience — Posted on 2024-12-02
4900 How much is 'enough'? Considerations for functional connectivity reliability in pediatric naturalistic fMRI
Rai, S. S.; Godfrey, K. J.; Graff, K.; Tansey, R.; Merrikh, D.; Yin, S.; Feigelis, M.; Demeter, D. V.; Vanderwal, T.; Greene, D. J.; Bray, S. L.
10.1101/2024.12.02.626468 — neuroscience — Posted on 2024-12-02
4904 The VGCC auxiliary subunit α2δ1 is an extracellular GluA1 interactor and regulates LTP, spatial memory, and seizure susceptibility
Leana-Sandoval, G.; Kolli, A. V.; Sandoval, M. A.; Saavedra, E. M.; Li, K. H.; Chen, L. Y.; Burlingame, A. L.; Ramirez-Franco, J. J.; Diaz-Alonso, J.
10.1101/2024.12.02.626379 — neuroscience — Posted on 2024-12-02
4905 ARBEL: A Machine Learning Tool with Light-Based Image Analysis for Automatic Classification of 3D Pain Behaviors
Barkai, O.; Zhang, B.; Lenfers Turnes, B.; Arab, M.; Zhang, Z.; Yarmolinsky, D. A.; Barrett, L. B.; Woolf, C. J.
10.1101/2024.12.01.625907 — neuroscience — Posted on 2024-12-02
4912 Overactivation of prefrontal astrocytes impairs cognition through the metabolic pathway of central kynurenines
Beilmann, V.; Furrer, J.; Schalbetter, S. M.; Weber-Stadlbauer, U.; Wyss, M. T.; Saab, A. S.; Weber, B.; Meyer, U.; Notter, T.
10.1101/2024.12.02.626319 — neuroscience — Posted on 2024-12-02
4913 Characterizing the Responses of Camelina and Sorghum to Environmental Stress through a Multi-Modal Approach
Seitz, K. A.; Morales, D. P.; Bristow, S. T.; Pauer, E. G.; Ryan, D. P.; Newell, R. T.; Hanson, D. T.; Warner, J. H.
10.1101/2024.10.30.621092 — plant biology — Posted on 2024-12-02
4917 Sex-specific DNA methylation signatures of autism spectrum disorder in newborn blood
Mouat, J. S.; Krigbaum, N. Y.; Hakam, S.; Thrall, E.; Kuodza, G.; Mellis, J.; Yasui, D. H.; Cirillo, P. M.; Ludena, Y.; Schmidt, R. J.; La Merrill, M. A.; Hertz-Picciotto, I.; Cohn, B. A.; LaSalle, J. M.
10.1101/2024.07.11.603098 — genomics — Posted on 2024-12-02
4920 Bilingual Exposure and Sex Shape Developmental Trajectories of Brain Responses to Speech-Sound Features in Infants
Puertollano, M.; Gorina-Careta, N.; Ijjou-Kadiri, S.; Mondejar-Segovia, A.; Gomez-Roig, M. D.; Escera, C.
10.1101/2024.12.02.626326 — developmental biology — Posted on 2024-12-02
4921 Analysis of gene expression in Aedes aegyptisuggests changes in early genetic control of mosquito development
dos Santos, R. C.; dos Santos, D. d. G.; Neto, L. R. G.; Munoz, J. J. M.; Uhl, M. V. d. C.; de Oliveira, C. J. L.; Amarante, A. d. M.; Fantappie, M. R.; da Fonseca, R. N.
10.1101/2024.12.02.625715 — developmental biology — Posted on 2024-12-02
4922 Dynamic Regulation Of The Chromatin Environment By ASH1L Modulates Human Neuronal Structure And Function
Jhanji, M.; Ward, J. A.; Leung, C. S.; Krall, C. L.; Ritchie, F. D.; Vestergaard, K.; Guevara, A.; Yoon, B.; Amin, K.; Berto, S.; Shih-Hwa Liu, J.; Lizarraga, S. B.
10.1101/2024.12.02.625500 — neuroscience — Posted on 2024-12-02
4923 Hyperactive neuronal networks facilitate tau spread in an Alzheimer's disease mouse model
Barbour, A. J.; Hoag, K.; Cornblath, E. J.; Chaveez, A.; Lucas, A.; Li, X.; Zebrowitz, S.; Hassman, C.; Lee, E. B.; Davis, K. A.; Lee, V. M. Y.; Talos, D. M.; Jensen, F. E.
10.1101/2024.12.01.625514 — neuroscience — Posted on 2024-12-02
4925 Ventral pallidal GABAergic neurons drive consumption in male, but not female rats
Scott, A.; Paulson, A.; Prill, C.; Kermoade, K.; Newell, B.; Richard, J. M.
10.1101/2024.04.30.591876 — neuroscience — Posted on 2024-12-02
4929 Asynchronous subunit transitions precede acetylcholine receptor activation
Thompson, M. J.; Tessier, C. J. G.; Ananchenko, A.; Emlaw, J. R.; Dehez, F.; Zarkadas, E.; daCosta, C. J. B.; Nury, H.; Baenziger, J. E.
10.1101/2024.12.02.626350 — neuroscience — Posted on 2024-12-02
4930 Death in the taste bud: engulfment of dying taste receptor cells by glial-like Type I cells
Wilson, C. E.; Lasher, R. S.; Salcedo, E.; Yang, R.; Dzowo, Y.; Kinnamon, J. C.; Finger, T. E.
10.1101/2024.09.06.611711 — neuroscience — Posted on 2024-12-02
4937 Dynamic evolution of satellite DNAs drastically differentiates the genomes of Tribolium sibling species
Veseljak, D.; Despot-Slade, E.; Volaric, M.; Horvat, L.; Vojvoda Zeljko, T.; Mestrovic, N.; Mravinac, B.
10.1101/2024.12.02.626372 — genomics — Posted on 2024-12-02
4938 Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma
Tandukar, B.; Deivendran, D.; Chen, L.; Cruz-Pacheco, N.; Sharma, H.; Xu, A.; Bandari, A. K.; Chen, D.; George, C.; Marty, A.; Cho, R. J.; Cheng, J.; Saylor, D.; Gerami, P.; Arron, S. T.; Bastian, B. C.; Shain, A. H.
10.1101/2024.07.23.604673 — genomics — Posted on 2024-12-02
4939 Study design and the sampling of deleterious rare variants in biobank-scale datasets
Steiner, M. C.; Rice, D. P.; Biddanda, A.; Ianni-Ravn, M. K.; Porras, C.; Novembre, J.
10.1101/2024.12.02.626424 — genetics — Posted on 2024-12-02
4941 Global population structure of a unicellular marine predator
Latorre, F.; Jaillon, O.; Sieracki, M. E.; Cruaud, C.; Massana, R.; Logares, R.
10.1101/2024.11.27.625609 — ecology — Posted on 2024-12-02
4942 USP7 Inhibition Promotes Early Osseointegration in Senile Osteoporotic Mice
Zhou, F.; Wang, Z.; Li, H.; Wang, D.; Wu, Z.; Bai, F.; Wang, Q.; Luo, W.; Zhang, G.; Xiong, Y.; Wu, Y.
10.1101/2023.11.15.567232 — cell biology — Posted on 2024-12-02
4943 Necrosis drives susceptibility to Mycobacterium tuberculosis in PolgD257A mutator mice
Mabry, C. J.; Weindel, C. G.; Stranahan, L. W.; West, P. L.; Davis, J. R.; Martinez, E. L.; VanPortfliet, J. J.; Patrick, K. L.; Watson, R. O.
10.1101/2024.07.17.603991 — immunology — Posted on 2024-12-02
4944 Spatial learning in feature-impoverished environments in Drosophila
Chen, Y.; Alfredson, R.; Motevalli, D.; Fogleman, S.; Stern, U.; Yang, C.-H.
10.1101/2024.09.28.615625 — neuroscience — Posted on 2024-12-02
4945 Long-term high temperatures affect seed maturation and seed coat integrity in Brassica napus
Prabhullachandran, U.; Urbankova, I.; Medaglia-Mata, A.; Creff, A.; Voxeur, A.; Petrik, I.; Pencik, A.; Novak, O.; Landrein, B.; Hejako, J.; Robert, H. S.
10.1101/2024.11.27.625589 — plant biology — Posted on 2024-12-02
4946 Cell-Cell Fusion in NSCLC Confers a Fitness Benefit Under Drug Selection
Shultes, P. V.; Tadele, D. S.; Durmaz, A.; Weaver, D. T.; Barker-Clarke, R.; Dinh, M. N.; Liu, S.; Alemu, E. A.; Rayner, S.; Scott, J. G.
10.1101/2024.12.02.626399 — cancer biology — Posted on 2024-12-02
4949 Ancient genomics support deep divergence between Eastern and Western Mediterranean Indo-European languages
Yediay, F. E.; Kroonen, G.; Sabatini, S.; Frei, K. M.; Frank, A. B.; Pinotti, T.; Wigman, A.; Thorso, R.; Vimala, T.; McColl, H.; Moutafi, I.; Altinkaya, I.; Ramsoe, A.; Gaunitz, C.; Renaud, G.; Mederos Martin, A.; Demeter, F.; Scorrano, G.; Canci, A.; Fischer, P.; Duyar, I.; Serhal, C.; Varzari, A.; Turkteki, M.; O'Shea, J.; Rahmstorf, L.; Polat, G.; Atamturk, D.; Vinner, L.; Omura, S.; Matsumura, K.; Cao, J.; Valeur Seersholm, F.; Morillo Leon, J. M.; Voutsaki, S.; Orgeolet, R.; Burke, B.; Herrmann, N. P.; Recchia, G.; Corazza, S.; Borgna, E.; Cipolloni Sampo, M.; Trucco, F.; Pajuelo Pando,
10.1101/2024.12.02.626332 — genetics — Posted on 2024-12-02
4950 Analysis of lifespan across Diversity Outbred mouse studies identifies multiple longevity-associated loci
Mullis, M. N.; Wright, K. M.; Raj, A.; Gatti, D. M.; Reifsnyder, P.; Flurkey, K.; Archer, J. R.; Robinson, L.; Di Franscesco, A.; Svenson, K. L.; Korstanje, R.; Harrison, D. E.; Ruby, J. G.; Churchill, G. A.
10.1101/2024.11.20.624531 — genetics — Posted on 2024-12-02
4951 Elevational and Oceanic Barriers Shape the Distribution, Dispersal and Diversity of Aotearoa's Kapokapowai (Uropetala) Dragonflies
Tolman, E. R.; Beatty, C. D.; Goodman, A. G.; Ramchand, P.; McAllister, T.; Reyes, K.; Zahara, A.; Taveras, K.; Wade, V.; Abbott, J.; Frandsen, P. B.; Guralnick, R.; Kohli, M. K.; Ware, J. L.; Suvorov, A.
10.1101/2024.11.25.625207 — evolutionary biology — Posted on 2024-12-02
4954 Detection of bacteria through taste receptors primes the cellular immune response
Mazariegos, A. N.; Maniere, G.; Camp, D.; Khaul, R.; Duval, C. J.; Milleville, R.; Berthelot-Grosjean, M.; Alves, G.; Royet, J.; Grosjean, Y.; Musso, P.-y.; Tanentzapf, G.
10.1101/2024.09.26.615243 — immunology — Posted on 2024-12-02
4955 Mesoscale functional architecture in medial posterior parietal cortex
Hira, R.; Townsend, L. B.; Smith, I. T.; Yu, C.-H.; Stirman, J. N.; Yu, Y.; Smith, S. L.
10.1101/2023.08.27.555017 — neuroscience — Posted on 2024-12-02
4956 Interpretable deep learning for deconvolutional analysis of neural signals
Tolooshams, B.; Matias, S.; Wu, H.; Temereanca, S.; Uchida, N.; Murthy, V. N.; Masset, P.; Ba, D.
10.1101/2024.01.05.574379 — neuroscience — Posted on 2024-12-02
4957 A Subset of Cortical Areas Exhibit Adult-like Functional Network Patterns in Early Childhood
Tu, J. C.; Wang, Y.; Wang, X.; Dierker, D.; Sobolewski, C. M.; Day, T. K. M.; Kardan, O.; Miranda Dominguez, O.; Moore, L. A.; Feczko, E. J.; Fair, D. A.; Elison, J. T.; Gordon, E. M.; Laumann, T. O.; Eggebrecht, A. T.; Wheelock, M. D.
10.1101/2024.07.31.606025 — neuroscience — Posted on 2024-12-02
4959 Two antagonistic gene regulatory networks drive Arabidopsis root hair growth at low temperature
Urzua, T.; Berdion Gabarain, V.; Ibeas, M. A.; Salinas-Grenet, H.; Acha, R.; Moyano, T.; Ferrero, L.; Nunez-Lillo, G.; Perez, J.; Perotti, F.; Miguel, V. N.; Spies, F. P.; Rosas, M. A.; Kawamura, A.; Rodriguez-Garcia, D.; Kim, A.-R.; Nolan, T.; Moreno, A. A.; Sugimoto, K.; Perrimon, N.; Sanguinet, K.; Meneses, C.; Chan, R. L.; Ariel, F.; Alvarez, J. M.; Estevez, J.
10.1101/2024.04.09.588718 — plant biology — Posted on 2024-12-02
4962 TEMPTED: Time-Informed Dimensionality Reduction for Longitudinal Microbiome Studies
Shi, P.; Martino, C.; Han, R.; Janssen, S.; Buck, G.; Serrano, M.; Owzar, K.; Knight, R.; Shenhav, L.; Zhang, A. R.
10.1101/2023.07.26.550749 — bioinformatics — Posted on 2024-12-02
4965 Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in trachea-esophageal morphogenesis
Edwards, N. A.; Rankin, S. A.; Kashyap, A.; Warren, A.; Agricola, Z.; Kenny, A. P.; Kofron, M. J.; Shen, Y.; Chung, W. K.; Zorn, A. M.
10.1101/2023.10.11.561909 — developmental biology — Posted on 2024-12-02
4966 Uncovering the regulatory landscape of early human B-cell lymphopoiesis and its implications in the pathogenesis of B-cell acute lymphoblastic leukemia
Planell, N.; Martinez-de-Morentin, X.; Mouzo, D.; Lara-Astiaso, D.; Vilas-Zornoza, A.; San Martin-Uriz, P.; Alignani, D.; Paiva, B.; Maillo, A.; Kurowska, A.; Berastegui, N.; Garcia-Olloqui, P.; Urdangarin, A.; Noori, P.; Ortega-Legarreta, A.; Hernaez, M.; Lagani, V.; Kiani, N.; Merkenschlager, M.; Ezponda, T.; Martin-Subero, J. I.; Ramirez, R. N.; Tegner, J.; Prosper, F.; Gomez-Cabrero, D.
10.1101/2023.07.01.547234 — immunology — Posted on 2024-12-02
4968 Pain persists in mice lacking both Substance P and CGRPα signaling
MacDonald, D. I.; Jayabalan, M.; Seaman, J. T.; Balaji, R.; Nickolls, A. R.; Chesler, A. T.
10.1101/2023.11.15.567208 — neuroscience — Posted on 2024-12-02
4969 Post-ejaculatory Inhibition of Female Sexual Drive via Heterogeneous Neuronal Ensembles in the Medial Preoptic Area
Ishii, K. K.; Hashikawa, K.; Chea, J.; Yin, S.; Fox, R. E.; Kan, S.; Shah, M.; Zhou, C.; Navarrete, J.; Murry, A. D.; Szelenyi, E.; Golden, S.; Stuber, G.
10.1101/2023.09.08.556711 — neuroscience — Posted on 2024-12-02
4970 Wide Transition-State Ensemble as Key Component for Enzyme Catalysis
Jara, G. E.; Pontiggia, F.; Otten, R.; Agafonov, R. V.; Marti, M. A.; Kern, D.
10.1101/2023.10.03.560706 — biophysics — Posted on 2024-12-02
4974 Genome-scale prediction of gene ontology from mass fingerprints reveals new metabolic gene functions
Vavricka, C.; Mochizuki, M.; Yuzawa, S.; Murata, M.; Yoshida, T.; Watanabe, N.; Nakatsui, M.; Ishii, J.; Hara, K.; Alper, H. S.; Hasunuma, T.; Kondo, A.; Araki, M.
10.1101/2024.11.27.625594 — systems biology — Posted on 2024-12-02
4975 Differential Remodeling of the BRCA1 Interactome by a Unique Minimal Clinical Truncation Mutation
Chen, J.; Sardiu, M. E.; Rekowski, M. J.; Nde, J.; Clark, Z. S.; Anant, S.; Washburn, M. P.; Jensen, R. A.
10.1101/2024.11.26.625539 — cancer biology — Posted on 2024-12-02
4976 CEACAM1 Targets ABCA1 to Mediate Atrial Fibrillation via Lipophagy-Dependent Ferroptosis
Hu, W.-w.; Zou, J.-h.; Li, Z.-x.; Yang, B.-n.; Ma, X.; Zhou, R.; Pu, J.; Wang, J.; Zhao, L.
10.1101/2024.11.26.625561 — cancer biology — Posted on 2024-12-02
4979 Integrating metabolic scaling and coexistence theories
Saavedra, S.; Arroyo, J. I.; Deng, J.; Marquet, P. A.; Kempes, C. P.
10.1101/2023.02.28.530509 — ecology — Posted on 2024-12-02
4981 Targeted Bacteriophage T4 Nanoparticles Reverse HIV-1 Latency in CD4+ Human T Cells
Batra, H.; Zhu, J.; Jain, S.; Ananthaswamy, N.; Mahalingam, M.; Tao, P.; Lange, C.; Hill, S.; Zhong, C.; Kearney, M. F.; Hu, H.; Maldarelli, F.; Rao, V. B.
10.1101/2021.07.20.453091 — immunology — Posted on 2024-12-02
4984 Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs
Ghosh, S.; Lahens, N.; Barekat, K.; Tang, S.-Y.; Theken, K. N.; Ricciotti, E.; Sengupta, A.; Joshi, R.; Bushman, F. D.; Weljie, A.; Grosser, T.; FitzGerald, G. A.
10.1101/2024.11.26.625478 — systems biology — Posted on 2024-12-02
4985 fluxTrAM: Integration of tracer-based metabolomics data into atomically resolved genome-scale metabolic networks for metabolic flux analysis
Huang, L.; Preciat, G.; Alarcon-Gil, J.; Moreno, E. L.; Wegrzyn, A. B.; Thiele, I.; Schymanski, E. L.; Harms, A. C.; Fleming, R. M.; Hankemeier, T.
10.1101/2024.11.26.625485 — systems biology — Posted on 2024-12-02
4988 A novel RyR2-selective stabilizer prevents and ameliorates severe arrhythmias in stress-induced ventricular tachycardia
Kurebayashi, N.; Kodama, M.; Murayama, T.; Konishi, M.; Sugihara, M.; Inoue, H.; Ishida, R.; Ishii, K.; Mori, S.; Endo, Y.; Zeng, X.; Inoue, Y. U.; Inoue, T.; Noguchi, S.; Nishio, H.; Yokoyama, U.; Kurokawa, J.; Kagechika, H.; Sakurai, T.
10.1101/2024.11.26.625386 — pharmacology and toxicology — Posted on 2024-12-02
4989 Constrained hypermutation and absence of TERT promoter mutations in Lynch syndrome-associated urothelial cancer
Nikkola, J.; Ryyppö, L.; Vuorinen, J.; Moilanen, L.; Ahtiainen, M.; Pylvänäinen, K.; Selin, H.; Virtanen, T.; Nykter, M.; Veitonmäki, T.; Mecklin, J.-P.; Seppälä, T. T.; Annala, M.
10.1101/2024.11.27.624238 — cancer biology — Posted on 2024-12-02
4990 Adherent-to-suspension transition promotes melanoma metastatic dissemination
Lee, D. K.; Oh, J.; Lee, S.; Huh, H. D.; Sub, Y.; Park, H. W.; Gee, H. Y.
10.1101/2024.11.26.625571 — cancer biology — Posted on 2024-12-02
4991 Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography
Zhou, H.; Hutchings, J.; Shiozaki, M.; Zhao, X.; Doolittle, L. K.; Yang, S.; Yan, R.; Jean, N.; Riggi, M.; Yu, Z.; Villa, E.; Rosen, M. K.
10.1101/2024.12.01.626131 — biophysics — Posted on 2024-12-02
4992 Charge distribution of coating brush drives inter-chromosome attraction
Sorichetti, V.; Robin, P.; Palaia, I.; Hernandez-Armendariz, A.; Cuylen-Haering, S.; Saric, A.
10.1101/2024.12.01.626236 — biophysics — Posted on 2024-12-02
4993 Quantitative Attributions with Counterfactuals
Adjavon, D.-Y.; Eckstein, N.; Bates, A. S.; Jefferis, G. S. X. E.; Funke, J.
10.1101/2024.11.26.625505 — bioinformatics — Posted on 2024-12-02
4994 Isobaric labeling update in MaxQuant
Ferretti, D.; Kyriakidou, P.; Xiao, J.; Urazbakhtin, S.; De Nart, C.; Cox, J.
10.1101/2024.09.30.615788 — bioinformatics — Posted on 2024-12-02
4996 Integration of spatial multiplexed protein imaging and transcriptomics in the human kidney tracks the regenerative potential timeline of proximal tubules
Asghari, M.; Sabo, A. R.; Barwinska, D.; Melo Ferreira, R.; Ferkowicz, M.; Bowen, W.; Cheng, Y.; Gisch, D.; Gulbronson, C.; Phillips, C. L.; Kelly, K. J.; Sutton, T. A.; Williams, J.; Vazquez, M.; O'Toole, J.; Palevsky, P.; Rosas, S.; Waikar, S. S.; Kiryluk, K.; Parikh, C.; Hodgins, J.; Sarder, P.; De Boer, I.; Himmelfarb, J.; Kretzler, M.; Kidney Precision Medicine Project, ; Jain, S.; Eadon, M.; Winfree, S.; El-Achkar, T. M.; Dagher, P. C.
10.1101/2024.11.26.625544 — bioinformatics — Posted on 2024-12-02
5001 Convergent cellular adaptation to a quiescence-like state in response to freeze-thaw stress
Tvishamayi, C.; Ali, F.; Chaturvedi, N.; Madhu-Kumar, N.; Rashida, Z.; Ray, A.; Thutupalli, S.
10.1101/2024.11.26.625389 — evolutionary biology — Posted on 2024-12-02
5002 Evolution of thermal tolerance in marine diatoms: Metabolic strategies under heat stress.
Aranguren-Gassis, M.; Diz, A. P.; Huete-Ortega, M.; Allen, A.; Litchman, E.
10.1101/2024.11.27.625584 — ecology — Posted on 2024-12-02
5007 Two Novel Red-FRET ERK Biosensors in the 670-720nm Range.
DeCuzzi, N. L.; Hu, J. Y.; Xu, F.; Rodriguez, B.; Pargett, M.; Albeck, J. G.
10.1101/2024.11.30.626109 — cell biology — Posted on 2024-12-02
5009 Mapping single-cell rheology of ascidian embryos in the cleavage stages using AFM
Kotani, T.; Matsuo, T.; Yokobori, M.; Tsuboyama, Y.; Miyata, Y.; Fujii, Y.; Kuribayashi-Shigetomi, K.; Okajima, T.
10.1101/2024.12.01.625795 — cell biology — Posted on 2024-12-02
5010 Cell type-Specific In Vivo Proteomes with a Multi-copy Mutant Methionyl t-RNA Synthetase Mouse Line
Schuman, E. M.; Alvarez Pardo, R.; tom Dieck, S.; Desch, K.; Nassim Assir, B.; Olmedo Salinas, C.; Sivakumar, R.; Langer, J. D.; Alvarez-Castelao, B.
10.1101/2024.11.28.625838 — cell biology — Posted on 2024-12-02
5015 LRRK2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis
Pei, J.; Oliveira, N. L.; Recinto, S. J.; Kazanova, A.; Queiroz-Junior, C. M.; Li, Z.; Couto, K.; Westfall, S.; King, I. L.; Ribeiro, C. T.; Milnerwood, A.; Desjardins, M.; Thanabalasuriar, A.; STRATTON, J. A.; Gruenheid, S.
10.1101/2024.11.26.625468 — immunology — Posted on 2024-12-02
5016 Impact of a transient neonatal visual deprivation on the development of the ventral occipito-temporal cortex in humans
Mattioni, S.; Rezk, M.; Gao, X.; Nam, J.; Liu, Z.-X.; Gau, R.; Goffaux, V.; Constantino, A.; Op de Beeck, H.; Lewis, T.; Maurer, D.; Collignon, O.
10.1101/2024.11.30.625697 — neuroscience — Posted on 2024-12-02
5018 Recombinant production of spider silk protein in Physcomitrella photobioreactors
Ramezaniaghdam, M.; Bohlender, L. L.; Parsons, J.; Hoernstein, S. N. W.; Decker, E. L.; Reski, R.
10.1101/2024.11.27.625602 — plant biology — Posted on 2024-12-02
5020 Positron emission tomography (PET) tracer enables imaging of high CD73 expression in cancer
Dobelmann, C.; Schmies, C. C.; Rolshoven, G.; Scortichini, M.; Wagner, S.; Isaak, A.; Idris, R. M.; Dabel, J.; Grey, L.; Losenkova, K.; Moschuetz, S.; Keim, A.; Hoeppner, S.; Sandholm, J.; Bostroem, P.; Hollmen, M.; Straeter, N.; Hermann, S.; Yegutkin, G. G.; Jacobson, K. A.; Schelhaas, S.; Mueller, C. E.; Junker, A.
10.1101/2024.11.29.625970 — cancer biology — Posted on 2024-12-02
5021 Unveiling miR-451a and miR-142-3p as Prognostic Markers in NSCLC via sEV Liquid Biopsy
Burdiel Herencia, M.; Arauzo Cabrera, A.; Jimenez, J.; Moreno, R.; Rodriguez Antolin, C.; Pernia, O.; Higuera, O.; Gutierrez Sainz, L.; Yubero, P.; Villamayor Sanchez, J.; Losantos Garcia, I.; Enrill Sagales, N.; Gonzalez Rumayor, V.; de Castro, J.; Ibanez de Caceres, I.; Vera, O.
10.1101/2024.11.29.622968 — cancer biology — Posted on 2024-12-02
5024 Illuminating root-soil mechanics
Le Houx, J.; McKay Fletcher, D.; Leonardi, A.; Williams, K.; Walker, N.; Albarez Borges, F.; Afsar Dizaj, E.; Murthy, M.; Smith, R.; Perera, L.; Asiani, N.; James, A.; Ahmed, S.; Roose, T.; Ruiz, S.
10.1101/2024.10.02.616056 — biophysics — Posted on 2024-12-02
5026 Active Remote Focus Stabilization in Oblique Plane Microscopy
Nguyen, D. T.; Rahmani, A.; Ponjavic, A.; Millett-Sikking, A.; Fiolka, R. P.
10.1101/2024.11.29.626121 — biophysics — Posted on 2024-12-02
5030 Optical tomography reconstructing 3D motion and structure of multiple-scattering samples under rotational actuation
Moser, S.; Kvale Lovmo, M.; Strasser, F.; Hagenbuchner, J.; Ausserlechner, M. J.; Ritsch-Marte, M.
10.1101/2024.11.27.624241 — bioengineering — Posted on 2024-12-02
5031 Spatial position relative to group members affects weight gain in meerkats (Suricata suricatta)
Mosia, R.; Demartsev, V.; le Roux, A.; Manser, M. B.; Strandburg-Peshkin, A.; Johnson-Ulrich, L.
10.1101/2024.11.29.625976 — animal behavior and cognition — Posted on 2024-12-02
5034 Genotypic and phenotypic consequences of domestication in dogs
Sweetalana, ; Nataneli, S.; Huang, S.; Mooney, J. A.; Szpiech, Z. A.
10.1101/2024.05.01.592072 — evolutionary biology — Posted on 2024-12-02
5035 A comparative analysis of planarian regeneration specificity reveals tissue polarity contributions of the axial cWnt signalling gradient.
Cleland, J. P.; Vu, H. T.- K.; Dickmann, J. E. M.; Rozanski, A.; Werner, S.; Schuhmann, A.; Shevchenko, A.; Rink, J. C.
10.1101/2024.12.01.626254 — developmental biology — Posted on 2024-12-02
5036 The mycobacterial nucleoid-associated protein NapM exhibits stress-induced septal localization and modulates cell envelope gene expression
Milcarz, K.; Hołowka, J.; Pawełczyk, J.; Pasciak, M.; Lavrynchuk, Y.; Płocinski, P.; Zakrzewska-Czerwinska, J. Z.
10.1101/2024.11.29.625984 — molecular biology — Posted on 2024-12-02
5037 POLYGENIC DETERMINANTS OF H5N1 ADAPTATION TO BOVINE CELLS
Turnbull, M. L.; Zakaria, M. K.; Upfold, N. S.; Bakshi, S.; Das, U. R.; Magill, C.; Mojsiejczuk, L.; Herder, V.; Dee, K.; Liu, N.; Folwarczna, M.; Ilia, G.; Furnon, W.; Schultz, V.; Chen, H.; Devlin, R.; McCowan, J.; Young, A. L.; Po, W.-W.; Smollett, K.; Yaseen, M. A.; Filipe, A. D. S.; Iqbal, M.; Roberts, E.; Hughes, J.; Werling, D.; Murcia, P. R.; Palmarini, M.
10.1101/2024.11.29.626120 — microbiology — Posted on 2024-12-02
5039 Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response
Lu, L.-F.; Zhang, C.; Li, Z.-C.; Cui, B.-J.; Wang, Y.-Y.; Han, K.-J.; Xu, X.; Zhou, C.-J.; Zhou, X.-Y.; Wu, Y.; Xu, N.; Yang, X.-L.; Chen, D.-D.; Li, X.; Zhou, L.; Li, S.
10.1101/2024.04.23.590743 — immunology — Posted on 2024-12-02
5040 Purinergic Receptor P2Y13 Controls Activation and Mode of Division in Subependymal Adult Neural Stem Cells
Paniagua-Herranz, L.; Serrano-Lopez, J.; Llorente-Saez, C.; Perez-Sanz, M. L.; de Agustin-Duran, D.; Duart-Abadia, P.; Domingo-Muelas, A.; Vincelle-Nieto, A.; Bragado, P.; Manzano-Franco, D.; Arribas-Blazquez, M.; Olivos-Ore, L.; Gascon, S.; Gutierrez-Uzquiza, A.; Perez-Sen, R.; Delicado, E. G.; Gomez-Villafueres, R.; Reyes-Palomares, A.; Artalejo, A. R.; Farinas, I.; Ortega, F.
10.1101/2024.11.29.626065 — neuroscience — Posted on 2024-12-02
5041 Electroretinograms as a functional readout of neuronal integrity in neurodegeneration models of Drosophila melanogaster
Manuel, N.; Mallipudi, M.; Gajwani, A.; Gopalkrishna Shetty Sreenivasa Murthy, S.; Jupiter, D. C.; Krishnan, B.
10.1101/2024.11.29.626125 — neuroscience — Posted on 2024-12-02
5042 Cingulate cortex shapes early postnatal development of social vocalizations
Nagarajan, G.; Matrov, D.; Pearson, A. C.; Yen, C.; Bradley, S. P.; Chudasama, Y.
10.1101/2024.02.17.580738 — neuroscience — Posted on 2024-12-02
5044 Deuterium Metabolic Imaging Phenotypes Mouse Glioblastoma Heterogeneity Through Glucose Turnover Kinetics
Simoes, R. V.; Henriques, R. N.; Olesen, J. L.; Cardoso, B. M.; Fernandes, F. F.; Monteiro, M. A.; Jespersen, S.; Carvalho, T.; Shemesh, N.
10.1101/2024.06.23.600246 — cancer biology — Posted on 2024-12-02
5046 Modeling spatio-temporal annual changes in the probability of human tick-borne encephalitis (TBE) occurrence across Europe
Dagostin, F.; Erazo Quintero, D.; Marini, G.; Da Re, D.; Tagliapietra, V.; Avdicova, M.; Avsic-Zupanc, T.; Dub, T.; Fiorito, N.; Knap, N.; Gossner, C. M.; Kerlik, J.; Makela, H.; Markowicz, M.; Olyazadeh, R.; Richter, L.; Wint, W.; Zuccali, M. G.; Zygutiene, M.; Dellicour, S.; Rizzoli, A.
10.1101/2024.10.18.619031 — ecology — Posted on 2024-12-02
5049 Unveiling the potato cultivars with microbiome interactive traits for sustainable agricultural production
Zhao, T.; Vink, S. N.; Jia, X.; Erban, A.; Schaarschmidt, S.; Kopka, J.; Zuther, E.; Treder, K.; Michalowska, D.; Guyoneaud, R.; Elzenga, J. T. M.; Attard, E.; Falcao Salles, J.
10.1101/2024.08.21.609084 — microbiology — Posted on 2024-12-02
5051 Oxytocin receptor controls promiscuity and development in prairie voles
Sharma, R.; Berendzen, K. M.; Everitt, A.; Wang, B.; Williams, G.; Wang, S.; Quine, K.; Larios, R. D.; Long, K. L. P.; Hoglen, N.; Sulaman, B. A.; Heath, M. C.; Sherman, M.; Klinkel, R.; Cai, A.; Galo, D.; Caamal, L. C.; Goodwin, N. L.; Beery, A.; Bales, K. L.; Pollard, K. S.; Willsey, A. J.; Manoli, D. S.
10.1101/2024.09.25.613753 — neuroscience — Posted on 2024-12-02
5054 Directionality of Transcriptional Regulatory Elements
Chen, Y.; Shah, S. R.; Leung, A.; Paramo, M. I.; Cochran, K.; Kundaje, A.; Clark, A. G.; Lis, J. T.; Yu, H.
10.1101/2024.12.01.621925 — molecular biology — Posted on 2024-12-02
5055 Cell Type Specific Enhancers for Dorsolateral Prefrontal Cortex.
He, J.; Phan, B. N.; Kerkhoff, W. G.; Alikaya, A.; Brull, O. R.; Fredericks, J. M.; Hong, T.; Sedorovitz, M.; Srinivasan, C.; Leone, M. J.; Wirfel, O. M.; Dauby, S.; Tittle, R. K.; Lin, M. K.; Bostan, A. C.; Hooks, B. M.; Gharbawie, O. A.; Byrne, L. C.; Pfenning, A. R.; Stauffer, W. R.
10.1101/2024.12.01.626253 — neuroscience — Posted on 2024-12-02
5056 The GluA1 cytoplasmic tail regulates intracellular AMPA receptor trafficking and synaptic transmission onto dentate gyrus GABAergic interneurons, gating response to novelty
Leana-Sandoval, G.; Kolli, A. V.; Chinn, C. A.; Madrid, A.; Lo, I.; Sandoval, M. A.; Alizo Vera, V.; Simms, J.; Wood, M. A.; Diaz Alonso, J.
10.1101/2024.12.01.626277 — neuroscience — Posted on 2024-12-02
5058 Repeated evolution of supergenes on an ancient social chromosome
Lajmi, A.; Cohen, P.; Lee, C.-C.; Frenkel, Z.; Pellen, Y.; Privman, E.
10.1101/2024.12.01.626239 — evolutionary biology — Posted on 2024-12-02
5059 Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stress
Cowdin, M. A.; Pramanik, T.; Mohr-Allen, S. R.; Fu, Y.; Mills, A.; Varner, V. D.; Davis, G. E.; Cleaver, O.
10.1101/2024.12.01.626284 — developmental biology — Posted on 2024-12-02
5061 Circular RNAs correlate with DNA damage in ageing human placental tissue and in stillbirth
Arthurs, A. L.; Jackson, M. R.; McCullough, D.; SCOTT, H.; Barnett, C. P.; Webb, S. T.; Smith, M. D.; Jankovic-Karasoulos, T.; Dekker, G. A.; Roberts, C. T.
10.1101/2024.09.02.610398 — molecular biology — Posted on 2024-12-01
5062 Shared and unique lifetime stressor characteristics and network connectivity predict adolescent anxiety and depression
Qu, Y.; Chopra, S.; Qu, S.; Cocuzza, C. V.; Labache, L.; Bauer, C. C. C.; Morfini, F.; Whitfield-Gabrieli, S.; Slavich, G. M.; Joormann, J.; Holmes, A. J.
10.1101/2024.10.25.620373 — neuroscience — Posted on 2024-12-01
5066 Implementation of a Clostridium luticellarii genome-scale model for upgrading syngas fermentations
Scott, W. T.; Rockx, S.; Mariën, Q.; Regueira Lopez, A.; Candry, P.; Ganigue, R.; Koehorst, J. J.; Schaap, P. J.
10.1101/2024.11.26.625427 — systems biology — Posted on 2024-12-01
5067 The MUC5B promoter variant results in proteomic changes in the non-fibrotic lung
HERRERA, J. A.; Maslanka, M.; Blumhagen, R. Z.; Blomberg, R.; Lwin, N. Y.; Brancato, J.; Cool, C. D.; Huber, J. P.; Kurche, J. S.; Magin, C. M.; Hansen, K.; Yang, I. V.; Schwartz, D. A.
10.1101/2024.11.26.625453 — pathology — Posted on 2024-12-01
5068 LNS8801: An enantiomerically pure agonist of the G protein-coupled estrogen receptor suitable for clinical development
Natale, C. A.; Mercado, S.; Zhuang, R.; Aguirre-Portoles, C.; Olayide, I.; Arnatt, C. K.; Seykora, J. T.; Garyantes, T. K.; Luke, W.; Ridky, T. W.
10.1101/2024.11.26.625421 — cancer biology — Posted on 2024-12-01
5069 Drug combinations targeting FAK and MEK overcomes tumour heterogeneity in glioblastoma
Furqan, M.; Elliott, R. J.; Nagle, P.; Dawson, J. C.; Malalmeh, R.; Garcia, V. A.; Munro, A. F.; Drake, C.; Morrison, G. M.; Pollard, S. M.; Ebner, D.; Brunton, V. G.; Frame, M. C.; Carragher, N. O.
10.1101/2024.11.26.625442 — cancer biology — Posted on 2024-12-01
5075 Multiple full-length homozygous IGH haplotypes from Mauritian cynomolgus macaques
Olubo, S.; Gibson, W. S.; Prall, T. M.; Karl, J.; Wiseman, R. W.; O'Connor, D. H.; Douek, D.; Schramm, C. A.
10.1101/2024.11.27.625687 — genomics — Posted on 2024-12-01
5076 Comprehensive Enumeration of Cancer Stem-like Cell Heterogeneity Using Deep Neural Network
Chowdhury, D.; Priyadarshi, S.; Biswas, S.; Neekhra, B.; Gupta, D.; Haldar, S.
10.1101/2024.11.26.625418 — genomics — Posted on 2024-12-01
5077 TEAL-seq: Targeted Expression Analysis Sequencing
Doing, G.; Shanbhag, P.; Bell, I.; Cassidy, S.; Motakis, E.; Aiken, E.; Oh, J.; Adams, M. D.
10.1101/2024.11.26.625462 — genomics — Posted on 2024-12-01
5078 CRISPRa-mediated activation of genes associated with inherited retinal dystrophies in acutely isolated human cells for diagnostic purposes
Weber, V. J.; Reschigna, A.; Gerhardt, M. J.; Hinrichsmeyer, K. S.; Otify, D. Y.; Heigl, T.; Blaser, F.; Meneau, I.; Biel, M.; Michalakis, S.; Becirovic, E.
10.1101/2024.11.29.625601 — genetics — Posted on 2024-12-01
5079 The high quality Chinese white truffle genome and novel fossil-calibrated estimate of Pezizomycetes divergence reveal the tempo and mode of true truffles genome evolution
Martelossi, J.; Vujovic, J.; Huang, Y.; Tatti, A.; Xu, K.; Puliga, F.; Chen, Y.; Rota Stabelli, O.; Ghiselli, F.; Zhang, X.; Zambonelli, A.
10.1101/2024.11.26.625401 — evolutionary biology — Posted on 2024-12-01
5084 Tetramer formation of CpoS facilitates Inc-Inc interactions during Chlamydia trachomatis infection
Tijerina, X.; Jabeena, C. A.; Faris, R.; Xu, Z.; Smith, P.; Schnicker, N. J.; Weber, M. M.
10.1101/2024.12.01.621710 — microbiology — Posted on 2024-12-01
5085 Coordinated organic and inorganic nitrogen transformations fuel soil microbial blooms and increase nitrogen retention during snowmelt
Sorensen, P.; Karaoz, U.; Beller, H. R.; Bill, M.; Bouskill, N. J.; Banfield, J. F.; Chu, R. K.; Hoyt, D. W.; Eder, E.; Eloe-Fadrosh, E.; Sharrar, A. M.; Tfaily, M.; Toyoda, J.; Tolic, N.; Wang, S.; Wong, A.; Williams, K. H.; Zhong, Y.; Brodie, E. L.
10.1101/2024.11.30.626193 — microbiology — Posted on 2024-12-01
5086 Thrifty wide-context models of B cell receptor somatic hypermutation
Sung, K.; Johnson, M. M.; Dumm, W.; Simon, N.; Haddox, H.; Fukuyama, J.; Matsen, F. A.
10.1101/2024.11.26.625407 — immunology — Posted on 2024-12-01
5087 Structural basis of broad protection against influenza virus by a human antibody targeting the neuraminidase active site via a recurring motif in CDR H3
Jo, G.; Yamayoshi, S.; Ma, K. M.; Swanson, O.; Torres, J. L.; Ferguson, J. A.; Fernandez-Quintero, M. L.; Huang, J.; Copps, J.; Rodriguez, A. J.; Steichen, J. M.; Kawaoka, Y.; Han, J.; Ward, A. B.
10.1101/2024.11.26.625467 — immunology — Posted on 2024-12-01
5092 Pathogenesis of mtDNA point mutation m.10191T>C affecting complex I function is a multifactorial process leading to metabolic remodeling of mitochondria
Ahmadi, Z. A.; Cabrera-Orefice, A.; Zaninello, M.; Barth, E.; Rodenburg, R.; Rugarli, E.; Brodesser, S.; Arnold, S.; Brandt, U.
10.1101/2024.12.01.626247 — biochemistry — Posted on 2024-12-01
5094 Discovery of diverse chimeric peptides in a eukaryotic proteome sets the stage for the experimental proof of the mosaic translation hypothesis
Cakir, U.; Gabed, N.; Koroglu, Y. E.; Kaya, S.; Sinharoy, S.; Benedito, V. A.; Brunet, M. A.; Roucou, X.; Kryvoruchko, I. S.
10.1101/2024.12.01.626167 — biochemistry — Posted on 2024-12-01
5096 Identification of genetic variation in genes linked to buparvaquone resistance in Theileria sp infecting dairy cattle in India.
Musale, P.; Khilari, A.; Gade, R.; Dhanikachalam, V.; Jadhav, S.; Bajpai, M.; Turakani, B.; Joshi, A.; Prajapati, A.; Srivastava, A.; Swaminathan, M.; Joshi, S.; Shanmugam, D.
10.1101/2024.11.28.625829 — genomics — Posted on 2024-12-01
5099 AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone
Elsheikh, A.; Driggers, C. M.; Truong, H. H.; Yang, Z.; Allen, J.; Henriksen, N.; Walczewska-Szewc, K.; Shyng, S.-L.
10.1101/2024.09.05.611490 — biochemistry — Posted on 2024-12-01
5102 National-scale acoustic monitoring of avian biodiversity and migration
Bick, A.; Bakkestuen, V.; Cretois, B.; Hillier, B.; Kalas, J. A.; Pedersen, M.; Raja, K.; Rosten, C.; Somveille, M.; Stokke, B.; Wiel, J.; Sethi, S. S.
10.1101/2024.05.21.595242 — ecology — Posted on 2024-12-01
5109 Renovating the Barnes maze for mouse models of Dementia with STARR FIELD: A 4-day protocol that probes learning rate, retention and cognitive flexibility.
Bertolli, A.; Halhouli, O.; Liu-Martinez, Y.; Blaine, B.; Thangavel, R.; Zhang, Q.; Emmons, E.; Narayanan, N.; Gumusoglu, S. B.; Geerling, J. C.; Aldridge, G.
10.1101/2024.11.30.625516 — neuroscience — Posted on 2024-12-01
5119 Mapping cis- and trans-regulatory target genes of human-specific deletions
Fair, T.; Pavlovic, B. J.; Swope, D.; Castillo, O. E.; Schaefer, N. K.; Pollen, A. A.
10.1101/2023.12.27.573461 — genetics — Posted on 2024-12-01
5120 Mapping HIV-1 RNA Structure, Homodimers, Long-Range Interactions and persistent domains by HiCapR
Zhang, Y.; Han, J.; Dejian, X.; Shen, W.; Li, P.; Lau, J. Y.; Li, J.; Li, L.; Kudla, G.; Zhao, Z.
10.1101/2024.09.03.610837 — genomics — Posted on 2024-12-01
5121 The impact of fold-dilution and diluent volume on the estimation of colony forming units in a bacterial culture
Jain, M.; Begum, S.; Bhuyan, S.; Nath, C.; Kashyap, U.; Dutta, L.; Giri, S. J.; Deka, N.; Mandal, M.; Kumar, A.; Ray, S. K.
10.1101/2024.11.28.625891 — microbiology — Posted on 2024-12-01
5123 Antigen presentation by tumor-associated macrophages drives tumor-infiltrating T cells from a progenitor exhaustion state to terminal exhaustion
Waibl Polania, J.; Hoyt-Miggelbrink, A. M.; Tomaszewski, W. H.; Wachsmuth, L. P.; Lorrey, S. J.; Wilkinson, D. S.; Lerner, E. C.; Woroniecka, K.; Finlay, J. B.; Ayasoufi, K.; Fecci, P. E.
10.1101/2023.08.11.553007 — immunology — Posted on 2024-12-01
5126 Adaptive cellular evolution in the intestinal tracts of hyperdiverse African cichlid fishes
Fages, A.; Luxey, M.; Ronco, F.; Huyghe, C. E. T.; Menon, P. N. K.; Indermaur, A.; Salzburger, W.; Tschopp, P.
10.1101/2024.11.28.625862 — evolutionary biology — Posted on 2024-12-01
5128 Personalized Medicine for Meningiomas: Drug Screening on Tumor Organoids Exposes Therapeutic Vulnerabilities to HDAC1/2i Panobinostat
Jungwirth, G.; Cao, J.; Lotsch, C.; Warta, R.; Moustafa, M.; Knoll, M.; Yu, T.; Braun, V.; Jassowicz, L.; Dao Trong, P.; Younsi, A.; Scherer, M.; Bendszus, M.; Krieg, S. M.; von Deimling, A.; Debus, J.; Sahm, F.; Abdollahi, A.; Unterberg, A.; Herold-Mende, C.
10.1101/2024.11.26.625347 — cancer biology — Posted on 2024-12-01
5130 Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes
Magri, M. S.; Voronov, D.; Foley, S.; Martinez-Garcia, P. M.; Franke, M.; Cary, G. A.; Santos-Pereira, J. M.; Cuomo, C.; Fernandez-Moreno, M.; Gil-Galvez, A.; Acemel, R. D.; Paganos, P.; Ku, C.; Ranđelovic, J.; Rusciano, M. L.; Firbas, P. N.; Gomez-Skarmeta, J. L.; Hinman, V. F.; Arnone, M. I.; Maeso, I.
10.1101/2024.11.30.626178 — evolutionary biology — Posted on 2024-12-01