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Archive, 2021-08

5 Characterisation of a nucleo-adhesome
Byron, A.; Griffith, B. G. C.; Herrero, A.; Loftus, A. E. P.; Koeleman, E. S.; Dawson, J. C.; Kogerman, L.; McGivern, N.; Culley, J.; Grimes, G. R.; Serrels, B.; von Kriegsheim, A.; Brunton, V. G.; Frame, M. C.
10.1101/2021.08.31.458428 — cell biology — Posted on 2021-08-31
6 Mena regulates the LINC complex to control actin-nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression
Li Mow Chee, F.; Beernaert, B.; Loftus, A. E. P.; Kumar, Y.; Griffith, B. G. C.; Wills, J. C.; Wheeler, A. P.; Armstrong, J. D.; Parsons, M.; Leigh, I. M.; Proby, C. M.; von Kriegsheim, A.; Bickmore, W. A.; Frame, M. C.; Byron, A.
10.1101/2021.08.31.458340 — cell biology — Posted on 2021-08-31
11 Translational gene expression control in Chlamydia trachomatis.
Grieshaber, N. A.; Chiarelli, T. J.; Appa, C. R.; Neiswanger, G.; Peretti, K.; Grieshaber, S. S.
10.1101/2021.08.31.458335 — microbiology — Posted on 2021-08-31
19 DeepConsensus: Gap-Aware Sequence Transformers for Sequence Correction
Baid, G.; Cook, D. E.; Shafin, K.; Yun, T.; Llinares-Lopez, F.; Berthet, Q.; Wenger, A. M.; Rowell, W. J.; Nattestad, M.; Yang, H.; Kolesnikov, A.; Topfer, A.; Ammar, W.; Vert, J.-P.; Vaswani, A.; McLean, C. Y.; Chang, P.-C.; Carroll, A.
10.1101/2021.08.31.458403 — bioinformatics — Posted on 2021-08-31
21 Preproteins couple the intrinsic dynamics of SecA to its ATPase cycle to translocate via a catch and release mechanism
Krishnamurthy, S.; Sardis, M. F.; Eleftheriadis, N.; Chatzi, K. E.; Smit, J. H.; Karathanou, K.; Gouridis, G.; Portaliou, A. G.; Bondar, A.-N.; Karamanou, S.; Economou, A.
10.1101/2021.08.31.458331 — biochemistry — Posted on 2021-08-31
22 Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits.
Rowland, B.; Venkatesh, S.; Tardaguila, M.; Wen, J.; Rosen, J. D.; Tapia, A. L.; Sun, Q.; Graff, M.; Vuckovic, D.; Lettre, G.; Sankaran, V. G.; Reiner, A. P.; Soranzo, N.; Huffman, J. E.; Voloudakis, G.; Roussos, P.; Raffield, L.; Li, Y.
10.1101/2021.08.03.453690 — genetics — Posted on 2021-08-31
24 Synaptotagmin 13 orchestrates pancreatic endocrine cell egression and islet morphogenesis
Bakhti, M.; Bastidas-Ponce, A.; Tritschler, S.; Tarquis-Medina, M.; Nedvedova, E.; Scheibner, K.; Jaki, J.; Cota, P.; Salinno, C.; Boldt, K.; Willmann, S.; Horn, N.; Ueffing, M.; Burtscher, I.; Theis, F.; Coskun, U.; Lickert, H.
10.1101/2021.08.30.458251 — developmental biology — Posted on 2021-08-31
25 LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion
Camillo, C.; Facchinello, N.; Villari, G.; Mana, G.; Gioelli, N.; Sandri, C.; Astone, M.; Tortarolo, D.; Clapero, F.; Gays, D.; Oberkersch, R. E.; Arese, M.; Tamagnone, L.; Valdembri, D.; Santoro, M. M.; Serini, G.
10.1101/2020.04.28.065979 — cell biology — Posted on 2021-08-31
26 Structure and RNA template requirements of Arabidopsis RNA-DEPENDENT RNA POLYMERASE 2
Fukudome, A.; Singh, J.; Mishra, V.; Reddem, E.; Martinez-Marquez, F.; Wenzel, S.; Yan, R.; Shiozaki, M.; Yu, Z.; Wang, J. C.-Y.; Takagi, Y.; Pikaard, C.
10.1101/2021.08.31.458351 — molecular biology — Posted on 2021-08-31
27 Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids
Han, S.-i.; Nakakuki, M.; Nakagawa, Y.; Wang, Y.; Araki, M.; Yamamoto, Y.; Tokiwa, H.; Takeda, H.; Mizunoe, Y.; Motomura, K.; Ohno, H.; Murayama, Y.; Aita, Y.; Takeuchi, Y.; Osaki, Y.; Miyamoto, T.; Sekiya, M.; Matsuzaka, T.; Yahagi, N.; Sone, H.; Kawano, H.; Shimano, H.
10.1101/2021.08.24.457590 — molecular biology — Posted on 2021-08-31
30 The evolutionary origin of host association in an ancient bacterial clade
Schon, M. E.; Martijn, J.; Vosseberg, J.; Kostlbacher, S.; Ettema, T. J. G.
10.1101/2021.08.31.458344 — microbiology — Posted on 2021-08-31
31 Subtle immunological differences in mRNA-1273 and BNT162b2 COVID-19 vaccine induced Fc-functional profiles
Kaplonek, P.; Cizmeci, D.; Fischinger, S.; Collier, A.-r.; Suscovich, T.; Linde, C.; Broge, T.; Mann, C.; Amanat, F.; Dayal, D.; Rhee, J.; de St. Aubin, M.; Nilles, E. J.; Musk, E. R.; Menon, A. S.; Ollmann Saphire, E.; Krammer, F.; Lauffenburger, D. A.; Barouch, D. H.; Alter, G.
10.1101/2021.08.31.458247 — immunology — Posted on 2021-08-31
36 The mechanobiology of craniosynostosis in Crouzon syndrome
Moazen, M.; Hejazi, M.; Savery, D.; Jones, D.; Marghoub, A.; Alazmani, A.; Pauws, E.
10.1101/2021.08.31.458360 — biophysics — Posted on 2021-08-31
38 Elucidation of Master Allostery Essential for Circadian Clock Oscillation in Cyanobacteria
Furuike, Y.; Mukaiyama, A.; Ouyang, D.; Ito-Miwa, K.; Simon, D.; Yamashita, E.; Kondo, T.; Akiyama, S.
10.1101/2021.08.30.457330 — biophysics — Posted on 2021-08-31
43 Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs
Maksimainen, M. M.; Murthy, S.; Sowa, S. T.; Galera-Prat, A.; Rolina, E.; Heiskanen, J. P.; Lehtiö, L.
10.1101/2021.08.30.458193 — biochemistry — Posted on 2021-08-31
44 Multicenter reverse-phase protein array data integration
de Koning, L.; Bernhardt, S.; Macleod, K. G.; Ouine, B.; Cartier, A.; Sibut, V.; Carragher, N. O.; Korf, U.; Serrels, B.; Byron, A.
10.1101/2021.08.31.458377 — biochemistry — Posted on 2021-08-31
47 Colloidal aggregators in biochemical SARS-CoV-2 repurposing screens
O'Donnell, H. R.; Tummino, T. A.; Bardine, C.; Craik, C. S.; Shoichet, B. K.
10.1101/2021.08.31.458413 — biochemistry — Posted on 2021-08-31
50 A unique Toxoplasma gondii haplotype under strong selection has accompanied domestic cats in their global expansion
Galal, L.; Ariey, F.; Gouilh, M. A.; Darde, M.-L.; Hamidovic, A.; Letourneur, F.; Prugnolle, F.; Mercier, A.
10.1101/2021.08.31.457674 — genomics — Posted on 2021-08-31
54 Periplasm homeostatic regulation maintains spatial constraints essential for cell envelope processes and cell viability
Mandela, E.; Stubenrauch, C. J.; Ryoo, D.; Hwang, H.; Cohen, E. J.; Torres, V. V. L.; Deo, P.; Webb, C. T.; Huang, C.; Schittenhelm, R. B.; Beeby, M.; C. Gumbart, J.; Lithgow, T.; Hay, I. D.
10.1101/2021.01.13.426498 — microbiology — Posted on 2021-08-31
56 Novel Cluster AZ Arthrobacter phages Powerpuff, Lego, and YesChef exhibit close functional relationships with Microbacterium phages
Kapinos, A.; Aghamalian, P.; Capehart, E.; Alag, A.; Angel, H.; Briseno, E.; Farag, E.; Foster, H.; Hakim, A.; Hernandez-Casas, D.; Huang, C.; Lam, D.; Mendez, M.; Min, A.; Nguyen, N.; Ortiz, E.; Saldivar, L. S.; Shannon, J. A.; Smith, R.; Sridhar, M. V.; Ta, A.; Theophilus, M. C.; Ngo, R.; Torres, C.; Reddi, K.; Freise, A. C.; Moberg Parker, J.
10.1101/2020.11.21.392811 — microbiology — Posted on 2021-08-31
61 Role of 5-HT2C receptors in zebrafish alarm reactions and post-exposure behavior
do Carmo Silva, R. X.; do Nascimento, B. G.; Gomes, G. C. V.; Holanda da Silva, N. A.; Pinheiro, J. S.; da Silva Chaves, S. N.; Pimentel, A. F. N.; Costa, B. P. D.; Herculano, A. M.; Lima-Maximino, M.; Maximino, C.
10.1101/2020.10.04.324202 — neuroscience — Posted on 2021-08-31
63 Distinct Processing of Selection and Execution Errors in Neural Signatures of Outcome Monitoring
Mushtaq, F.; McDougle, S. D.; Craddock, M. P.; Parvin, D.; Brookes, J.; Schaefer, A.; Mon-Williams, M.; Taylor, J. A.; Ivry, R. B.
10.1101/853317 — neuroscience — Posted on 2021-08-31
64 Cortico-Fugal Regulation of Predictive Coding.
Lesicko, A. M. H.; Angeloni, C. F.; Blackwell, J. M.; De Biasi, M.; Geffen, M. N.
10.1101/2021.04.12.439188 — neuroscience — Posted on 2021-08-31
66 Alterations in rhythmic and non-rhythmic resting-state EEG activity and their link to cognition in older age
Cesnaite, E.; Steinfath, T. P.; Idaji, M. J.; Stephani, T.; Kumral, D.; Haufe, S.; Sander, C.; Hensch, T.; Hegerl, U.; Riedel-Heller, S.; Roehr, S.; Schroeter, M. L.; Witte, V.; Villringer, A.; Nikulin, V.
10.1101/2021.08.26.457768 — neuroscience — Posted on 2021-08-31
67 Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor
Capraz, T.; Kienzl, N. F.; Laurent, E.; Perthold, J. W.; Foederl-Hoebenreich, E.; Gruenwald-Gruber, C.; Maresch, D.; Monteil, V.; Niederhoefer, J.; Wirnsberger, G.; Mirazimi, A.; Zatloukal, K.; Mach, L.; Penninger, J. M.; Oostenbrink, C.; Stadlmann, J.
10.1101/2021.08.31.458325 — biochemistry — Posted on 2021-08-31
69 Optimised production of disulfide-bonded fungal effectors in E. coli using CyDisCo and FunCyDisCo co-expression approaches
Yu, D. S.; Outram, M. A.; Crean, E.; Smith, A.; Sung, Y.-C.; Darma, R.; Sun, X.; Ma, L.; Jones, D. A.; Solomon, P. S.; Williams, S. J.
10.1101/2021.08.31.458447 — biochemistry — Posted on 2021-08-31
71 Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo
Solis, G. P.; Kazemzadeh, A.; Valnohova, J.; Abrami, L.; Alvarez, C.; van der Goot, F. G.; Katanaev, V. L.
10.1101/2020.08.25.266692 — cell biology — Posted on 2021-08-31
74 Physiological basis underlying antidepressant-induced activation of TrkB receptors
Alitalo, O.; Kohtala, S.; Rosenholm, M.; Kohtala, P.; Saarreharju, R.; Matsui, N.; Gonzalez Hernandez, G.; Kaastrup Muller, H.; Theilmann, W.; Sarparanta, M.; Klein, A.; Karkkainen, O.; Rozov, S.; Rantamaki, T.
10.1101/2021.08.30.458151 — neuroscience — Posted on 2021-08-31
75 Critical period for vision-dependent modulation of postnatal retinal neurogenesis
Tkatchenko, T. V.; Michurina, T.; Tomarev, S. I.; Nakaya, N.; Enikolopov, G. N.; Tkatchenko, A. V.
10.1101/2021.08.30.458213 — neuroscience — Posted on 2021-08-31
77 Theory of branching morphogenesis by local interactions and global guidance
Ucar, M. C.; Kamenev, D.; Sunadome, K.; Fachet, D.; Lallemend, F.; Adameyko, I.; Hadjab, S.; Hannezo, E.
10.1101/2021.08.30.458198 — biophysics — Posted on 2021-08-31
78 NetRAX: Accurate and Fast Maximum Likelihood Phylogenetic Network Inference
Lutteropp, S.; Scornavacca, C.; Kozlov, A. M.; Morel, B.; Stamatakis, A. M.
10.1101/2021.08.30.458194 — bioinformatics — Posted on 2021-08-31
82 Interannual climate variability data improves niche estimates in species distribution models
Karger, D. N.; Saladin, B.; Wueest, R. O.; Graham, C. H.; Zurell, D.; Mo, L.; Zimmermann, N. E.
10.1101/2021.08.30.458152 — ecology — Posted on 2021-08-31
93 Mutationathon: towards standardization in estimates of pedigree-based germline mutation rates
Bergeron, L. A.; Besenbacher, S.; Turner, T. N.; Versoza, C. J.; Wang, R.; Price, A. L.; Armstrong, E.; Riera, M.; Carlson, J.; Chen, H.-y.; Hahn, M. W.; Harris, K.; Kleppe, A. S. L. N. M.; Lopez-Nandam, E. H.; Moorjani, P.; Pfeifer, S. P.; Tiley, G. P.; Yoder, A. D.; Zhang, G.; Schierup, M. H.
10.1101/2021.08.30.458162 — evolutionary biology — Posted on 2021-08-31
97 Remarkably stable copy-number profiles in osteosarcoma revealed using single-cell DNA sequencing
Rajan, S.; Zaccaria, S.; Cannon, M. V.; Cam, M.; Gross, A. C.; Raphael, B. J.; Roberts, R. D.
10.1101/2021.08.30.458268 — cancer biology — Posted on 2021-08-31
98 Comparative assessment of genes driving cancer and somatic evolution.
Dressler, L.; Bortolomeazzi, M.; Keddar, M. R.; Misetic, H.; Sartini, G.; Acha-Sagredo, A.; Montorsi, L.; Wijewardhane, N.; Repana, D.; Nulsen, J.; Goldman, J.; Pollit, M.; Davis, P.; Strange, A.; Ambrose, K.; Ciccarelli, F. D.
10.1101/2021.08.31.458177 — cancer biology — Posted on 2021-08-31
102 Dynamics of poly(A) tail length and non-A residues during the human oocyte-to-embryo transition
Liu, Y.; Wu, K.; Shao, F.; Nie, H.; Zhang, J.; Li, C.; Hou, Z.; Wang, J.; Zhou, B.; Zhao, H.; Lu, F.
10.1101/2021.08.29.458075 — developmental biology — Posted on 2021-08-31
104 Disruption of the grid cell network in a mouse model of early Alzheimer's disease
Ying, J.; Keinath, A. T.; Lavoie, R.; Vigneault, E.; Mestikawy, S. E.; Brandon, M. P.
10.1101/2021.08.29.458090 — neuroscience — Posted on 2021-08-31
105 Neural evidence for the successor representation in choice evaluation
Russek, E. M.; Momennejad, I.; Botvinick, M. M.; Gershman, S. J.; Daw, N. D.
10.1101/2021.08.29.458114 — neuroscience — Posted on 2021-08-31
107 Neural signatures of teamwork: Evidence from real-world military training
Cross, Z. R.; Chatburn, A.; Melberzs, L.; Temby, P.; Pomeroy, D.; Schlesewsky, M.; Bornkessel-Schlesewsky, I.
10.1101/2021.08.29.456571 — neuroscience — Posted on 2021-08-31
108 Novel System to Monitor In Vivo Neural Graft Activity After Spinal Cord Injury
Ago, K.; Nagoshi, N.; Imaizumi, K.; Kitagawa, T.; Kawai, M.; Kajikawa, K.; Shibata, R.; Kamata, Y.; Kojima, K.; Shinozaki, M.; Kondo, T.; Iwano, S.; Miyawaki, A.; Ohtsuka, M.; Bito, H.; Kobayashi, K.; Shibata, S.; Shindo, T.; Kohyama, J.; Matsumoto, M.; Nakamura, M.; Okano, H.
10.1101/2021.08.29.458127 — neuroscience — Posted on 2021-08-31
109 NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats
Johnson, J.; Focken, T.; Khakh, K.; Tari, P. K.; Dube, C.; Williams, A.; Andrez, J.-C.; Bankar, G.; Bogucki, D.; Burford, K.; Chang, E.; Chowdhury, S.; Dean, R.; de Boer, G.; Decker, S.; Dehnhardt, C.; Feng, M.; Gong, W.; Goodchild, S. J.; Grimwood, M.; Hasan, A.; Hussainkhel, A.; Jia, Q.; Lee, S.; Li, J.; Lin, S.; Lindgren, A.; Lofstrand, V.; Mezeyova, J.; Namdari, R.; Nelkenbrecher, K.; Shuart, N. G.; Sojo, L.; Sun, S.; Taron, M.; Waldbrook, M.; Weeratunge, D.; Wesolowski, S.; Wilson, M.; Xie, Z.; Yoo, R.; Young, C.; Zenova, A.; Zhang, W.; Cutts, A. J.; Sherrington, R. P.; Pimstone, S. N.; W
10.1101/2021.08.29.458125 — pharmacology and toxicology — Posted on 2021-08-31
111 The polyglutamine amyloid nucleus in living cells is monomeric and has competing dimensions of order
Kandola, T.; Zhang, J.; Venkatesan, S.; Lerbakken, B.; Blanck, J. F.; Wu, J.; Unruh, J.; Berry, P.; Lange, J. L.; Von Schulze, A.; Box, A.; Cook, M.; Sagui, C.; Halfmann, R.
10.1101/2021.08.29.458132 — biophysics — Posted on 2021-08-31
114 Simpler and Faster Development of Tumor Phylogeny Pipelines
Ali, S.; Ciccolella, S.; Lucarella, L.; Della Vedova, G.; Patterson, M. D.
10.1101/2021.08.29.458137 — bioinformatics — Posted on 2021-08-31
115 Adaptation of anammox bacteria to low temperature via gradual acclimation and cold shocks: distinctions in protein expression, membrane composition and activities
Kouba, V.; Vejmelkova, D.; Zwolsman, E.; Hurkova, K.; Navratilova, K.; Laureni, M.; Vodickova, P.; Podzimek, T.; Hajslova, J.; Pabst, M.; van Loosdrecht, M.; Bartacek, J.; Lipovova, P.; Weissbrodt, D. G.
10.1101/2021.08.29.458117 — bioengineering — Posted on 2021-08-31
117 Src-dependent NM2A tyrosine-phosphorylation regulates actomyosin dynamics
Brito, C.; Mesquita, F. S.; Osorio, D.; Pereira, J. M.; Billington, N.; Sellers, J. R.; Xavier de Carvalho, A.; Cabanes, D.; Sousa, S.
10.1101/2020.08.12.246090 — cell biology — Posted on 2021-08-31
118 Real-Time Brain-Machine Interface Achieves High-Velocity Prosthetic Finger Movements using a Biologically-Inspired Neural Network Decoder
Willsey, M. S.; Nason, S. R.; Ensel, S. R.; Temmar, H.; Mender, M. J.; Costello, J. T.; Patil, P. G.; Chestek, C. A.
10.1101/2021.08.29.456981 — neuroscience — Posted on 2021-08-31
122 S-acylation is a positive regulator of FLS2-mediated plant immunity
Hurst, C. H.; Turnbull, D.; Gronnier, J.; Myles, S.; Pflughaupt, R. L.; Kopischke, M.; Davies, P.; Jones, S.; Robatzek, S.; Zipfel, C.; Hemsley, P.
10.1101/2021.08.30.457756 — plant biology — Posted on 2021-08-31
123 Hexose translocation mediated by SlSWEET5b is required for pollen maturation in Solanum lycopersicum
Ko, H.-Y.; Tseng, H.-W.; Ho, L.-H.; Wang, L.; Chang, T.-F.; Lin, A.; Ruan, Y.-L.; Neuhaus, H. E.; Guo, W.-J.
10.1101/2021.08.30.458256 — plant biology — Posted on 2021-08-31
125 Design of a radial multi-offset detection pattern for in vivo phase contrast imaging of the retinal ganglion cells in humans
Gofas, E.; Rui, Y.; Mece, P.; Zhang, M.; Snyder, V. C.; Vienola, K. V.; Lee, D.; Sahel, J.-A.; Grieve, K.; Rossi, E. A.
10.1101/2020.12.08.416826 — bioengineering — Posted on 2021-08-31
127 Measuring protected-area outcomes with leech iDNA: large-scale quantification of vertebrate biodiversity in Ailaoshan reserve
Ji, Y.; Baker, C. C.; Li, Y.; Popescu, V. D.; Wang, Z.; Wang, J.; Wang, L.; Wu, C.; Hua, C.; Yang, Z.; Yang, C.; Xu, C. C.; Wen, Q.; Pierce, N. E.; Yu, D. W.
10.1101/2020.02.10.941336 — ecology — Posted on 2021-08-31
128 The role of anatomical connection strength for interareal communication in macaque cortex
Vezoli, J.; Vinck, M.; Bosman, C. A.; Bastos, A. M.; Lewis, C. M.; Kennedy, H.; Fries, P.
10.1101/2020.12.15.422902 — neuroscience — Posted on 2021-08-31
129 Trick or Treat? Pollinator attraction in Vanilla pompona (Orchidaceae)
Watteyn, C.; Scaccabarozzi, D.; Muys, B.; Van der Schueren, N.; Van Meerbeek, K.; Guizar Amador, M. F.; Ackerman, J. D.; Cedeno Fonseca, M. V.; Chinchilla Alvarado, I. F.; Reubens, B.; Pillco Huarcaya, R.; Cozzolino, S.; Karremans, A. P.
10.1101/2021.08.30.458254 — plant biology — Posted on 2021-08-31
130 Binding of DNA origami to lipids: maximising yield and switching via strand-displacement
Singh, J. K. D.; Darley, E.; Ridone, P.; Gaston, J. P.; Abbas, A.; Wickham, S. F.; Baker, M. A.
10.1101/2020.06.01.128686 — biophysics — Posted on 2021-08-31
139 The B chromosome of Pseudococcus viburni: a selfish chromosome that exploits whole-genome meiotic drive
Vea, I. M.; de la Filia, A. G.; Jaron, K. S.; Mongue, A. J.; Ruiz-Ruano, F. J.; Barlow, S. J.; Nelson, R.; Ross, L.
10.1101/2021.08.30.458195 — evolutionary biology — Posted on 2021-08-31
141 Influenza A virus (H1N1) infection induces microglia activation and temporal dysbalance in glutamatergic synaptic transmission.
Düsedau, H. P.; Steffen, J.; Figueiredo, C. A.; Boehme, J. D.; Schultz, K.; Erck, C.; Korte, M.; Faber-Zuschratter, H.; Smalla, K.-H.; Dieterich, D.; Kröger, A.; Bruder, D.; Dunay, I. R.
10.1101/2021.08.30.458184 — immunology — Posted on 2021-08-31
143 Multiplane Mesoscope reveals distinct cortical interactions following expectation violations
Orlova, N.; Najafi, F.; Tsyboulski, D.; Seid, S.; Kivikas, S.; Kato, I.; Griffin, F.; Leon, A.; L'Heureux, Q.; North, K.; Swapp, J.; Nayan, C.; Hancock, N.; Ahmed, R.; Gelfand, E.; Cho, A.; Mace, K.; Howard, R.; Casal, L.; Lambert, S.; Lee, E. K.; Caldejon, S.; Waughman, X.; Williford, A.; Garrett, M.; Ollerenshaw, D.; Olsen, S. R.; Groblewski, P.; Saggau, P.; Lecoq, J.
10.1101/2020.10.06.328294 — neuroscience — Posted on 2021-08-31
144 Chloroplast photosystem I dimer and high resolution model of the complex with plastocyanin
Naschberger, A.; Mosebach, L.; Tobiasson, V.; Kuhlgert, S.; Scholz, M.; Perez-Boerema, A.; Takahashi, Y.; Hippler, M.; Amunts, A.
10.1101/2021.08.30.458224 — plant biology — Posted on 2021-08-31
145 R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B
McCann, J.; Cristini, A.; Law, E.; LEE, S.; Tellier, M.; Carpenter, M.; Beghe, C.; Kim, J.; Jarvis, M. C.; Stefanovska, B.; Temiz, N. A.; Bergstrom, E. N.; Salamango, D.; Brown, M.; Murphy, S.; Alexandrov, L.; Miller, K.; Gromak, N.; Harris, R.
10.1101/2021.08.30.458235 — cancer biology — Posted on 2021-08-31
146 SHED-dependent oncogenic signalling of the PEAK3 pseudo-kinase
OUNOUGHENE, y.; fourgous, E.; Boublik, Y.; Saland, E.; Guiraud, N.; recher, c.; urbach, s.; Fort, P. P.; Sarry, J.-E.; fesquet, d.; roche, s.
10.1101/2021.08.30.457780 — cancer biology — Posted on 2021-08-31
148 5WBF: A low-cost and straightforward whole blood filtration method suitable for whole-genome sequencing of Plasmodium falciparum clinical isolates
Coppee, R.; Mama, A.; Sarrasin, V.; Kamaliddin, C.; Adoux, L.; Palazzo, L.; Ndam, N. T.; Letourneur, F.; Ariey, F.; Houze, S.; Clain, J.
10.1101/2021.08.30.457783 — genomics — Posted on 2021-08-31
149 Dicer-to-Argonaute switch controls biogenesis of oncogenic miRNA
Buffa, F. M.; Winchester, L.; van Bijsterveldt, L.; Dhawan, A.
10.1101/2021.08.30.458145 — genomics — Posted on 2021-08-31
151 Cosmopolitanism at the Roman Danubian Frontier, Slavic Migrations, and the Genomic Formation of Modern Balkan Peoples
Olalde, I.; Carrion, P.; Mikic, I.; Rohland, N.; Mallick, S.; Lazaridis, I.; Korac, M.; Golubovic, S.; Petkovic, S.; Miladinovic-Radmilovic, N.; Vulovic, D.; Stewardson, K.; Lawson, A. M.; Zalzala, F.; Callan, K.; Tomanovic, Z.; Keckarevic, D.; Grbic, M.; Lalueza-Fox, C.; Reich, D. E.
10.1101/2021.08.30.458211 — evolutionary biology — Posted on 2021-08-31
152 Monosomies, trisomies and segmental aneuploidies differentially affect chromosomal stability
Hintzen, D. C.; Soto, M.; Schubert, M.; Bakker, B.; Spierings, D. C. J.; Szuhai, K.; Lansdorp, P. M.; Foijer, F.; Medema, R. H.; Raaijmakers, J. A.
10.1101/2021.08.31.458318 — cell biology — Posted on 2021-08-31
155 Loss of Secretory Pathway Ca2+ ATPase (SPCA1) Impairs Insulin Secretion and Reduces Autophagy in the Pancreatic Islet
Bone, R. N.; Tong, X.; Weaver, S. A.; Muralidharan, C.; Krishnan, P.; Kono, T. M.; Evans-Molina, C.
10.1101/2021.08.30.458203 — cell biology — Posted on 2021-08-31
160 The exosomes derived from urine of premature infants target MAPK8 via miR-30a-5p to protect cisplatin-induced acute kidney injury in mice
Ma, M.; Luo, Q.; Fan, L.; Li, W.; Li, Q.; Meng, Y.; Yun, C.; Wu, H.; Lu, Y.; Cui, S.; Liu, F.; Hu, B.; Guan, B.; Liu, H.; Huang, S.; Liang, W.; Morgera, S.; kraemer, B.; Luan, S.; Yin, L.; Hocher, B.
10.1101/2021.08.29.458088 — molecular biology — Posted on 2021-08-31
161 Template strand deoxyuridine promoter recognition by a viral RNA polymerase
Fraser, A.; Sokolova, M. L.; Drobysheva, A. V.; Gordeeva, J. V.; Borukhov, S.; Artamonova, T. O.; AlphaFold team, ; Severinov, K. V.; Leiman, P. G.
10.1101/2021.08.30.458274 — molecular biology — Posted on 2021-08-31
162 Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools
Markosian, C.; Staquicini, D. I.; Dogra, P.; Dodero-Rojas, E.; Tang, F. H. F.; Smith, T. L.; Contessoto, V. G.; Libutti, S. K.; Wang, Z.; Cristini, V.; Whitford, P. C.; Burley, S. K.; Onuchic, J. N.; Pasqualini, R.; Arap, W.
10.1101/2021.08.30.458222 — microbiology — Posted on 2021-08-31
164 Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge
Hilligan, K. L.; Namasivayam, S.; Clancy, C. S.; O'Mard, D.; Oland, S. D.; Robertson, S. J.; Baker, P. J.; Castro, E.; Garza, N. L.; Lafont, B. A. P.; Johnson, R.; Ronchese, F.; Mayer-Barber, K. D.; Best, S. M.; Sher, A.
10.1101/2021.08.30.458273 — immunology — Posted on 2021-08-31
165 A novel effective live-attenuated human metapneumovirus vaccine candidate produced in the serum-free suspension DuckCelt-T17 cell platform
Chupin, C.; Pizzorno, A.; Traversier, A.; Brun, P.; Ogonczyk-makowska, D.; Padey, B.; Milesi, C.; Duliere, V.; Laurent, E.; Julien, T.; Galloux, M.; Lina, B.; Eleouet, J.-F.; Moreau, K.; Hamelin, M.-E.; Terrier, O.; Boivin, G.; Dubois, J.; Rosa-Calatrava, M.
10.1101/2021.08.30.458186 — immunology — Posted on 2021-08-31
169 A gap-free tomato genome built from complementary PacBio and Nanopore long DNA sequences reveals extensive linkage drag during breeding
van Rengs, W. M. J.; Schmidt, M. H.- W.; Effgen, S.; Wang, Y.; Zaidan, M. W. A. M.; Huettel, B.; Schouten, H. J.; Usadel, B.; Underwood, C. J.
10.1101/2021.08.30.456472 — plant biology — Posted on 2021-08-31
170 Strikingly different roles of SARS-CoV-2 fusion peptides uncovered by neutron scattering
Santamaria, A.; Batchu, K. C.; Matsarskaia, O.; Prevost, S. F.; Russo, D.; Natali, F.; Seydel, T.; Hoffmann, I.; Laux, V.; Haertlein, M.; Darwish, T. A.; Russell, R. A.; Corucci, G.; Fragneto, G.; Maestro, A.; Zaccai, N. R.
10.1101/2021.08.30.458099 — biophysics — Posted on 2021-08-31
175 Genome-wide Disease Screening in Early Human Embryos with Primary Template-Directed Amplification
Xia, Y.; Gonzales-Pena, V.; Klein, D.; Luquette, J.; Puzon, L.; Siddiqui, N.; Reddy, V.; Park, P.; Behr, B.; Gawad, C.
10.1101/2021.07.06.451077 — bioengineering — Posted on 2021-08-31
176 Structural and Functional Analyses Explain Pea KAI2 Receptor Diversity and Reveal Stereoselective Catalysis During Signal Perception
Guercio, A. M.; Torabi, S.; Cornu, D.; Dalmais, M.; Bendahmane, A.; Le Signor, C.; Pillot, J.-P.; Le Bris, P.; Boyer, F.-D.; Rameau, C.; Gutjahr, C.; de Saint Germain, A.; Shabek, N.
10.1101/2021.01.06.425465 — biochemistry — Posted on 2021-08-31
177 Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma
Boyd, R. J.; Olson, T.; Zook, J.; Aceves, M.; Stein, D.; Lin, W.-H.; Craciunescu, F.; Hansen, D. T.; Anastasiadis, P. Z.; Singharoy, A.; Fromme, P.
10.1101/2021.08.26.457821 — biochemistry — Posted on 2021-08-31
178 Exploring the conformational landscape and stability of Aurora A using ion-mobility mass spectrometry and molecular modelling
Tomlinson, L. J.; Bachelor, M.; Byrne, D. P.; Sarsby, J.; Brownridge, P. J.; Bayliss, R.; Eyers, P. A.; Eyers, C. E.
10.1101/2021.08.30.458190 — biochemistry — Posted on 2021-08-31
180 Evolution of the canonical sex chromosomes of the guppy and its relatives
Kirkpatrick, M.; Sardell, J. M.; Pinto, B. J.; Dixon, G.; Peichel, C.; Schartl, M.
10.1101/2020.09.25.314112 — genomics — Posted on 2021-08-31
182 A sex-specific evolutionary interaction between ADCY9 and CETP
Gamache, I.; Legault, M.-A.; Grenier, J.-C.; Sanchez, R.; Rheaume, E.; Asgari, S.; Barhdadi, A.; Zada, Y. F.; Trochet, H.; Luo, Y.; Lecca, L.; Murray, M.; Raychaudhuri, S.; Tardif, J.-C.; Dube, M.-P.; Hussin, J. G.
10.1101/2021.05.12.443794 — genetics — Posted on 2021-08-31
183 Evidence of an additional center of apple domestication in Iran, with contributions from the Caucasian crab apple Malus orientalis
Bina, H.; Yousefzadeh, H.; Venon, A.; Remoue, C.; Rousselet, A.; Falque, M.; Faramarzi, S.; Xilong, C.; Samanchina, J.; Gill, D.; Kabaeva, A.; GIRAUD, T.; Hossainpour, B.; Hamid, A.; Gabrielyan, I.; Nersesyan, A.; Cornille, A. A.
10.1101/2021.03.28.437401 — evolutionary biology — Posted on 2021-08-31
184 Bacterial glycyl tRNA synthetase offers glimpses of ancestral protein topologies
Dimas-Torres, J.-U.; Rodriguez-Hernandez, A.; Valencia-Sanchez, M.-I.; Campos-Chavez, E.; Godinez-Lopez, V.; Rodriguez-Chamorro, D.-E.; Grotli, M.; Fleming, C.; Hernandez-Gonzalez, A.; Arciniega, M.; Torres-Larios, A.
10.1101/2021.08.20.456953 — evolutionary biology — Posted on 2021-08-31
187 Large positive ecological changes of small urban greening actions
Mata, L.; Hahs, A. K.; Palma, E.; Backstrom, A.; King, T.; Olson, A. R.; Renowden, C.; Smith, T. R.; Vogel, B.
10.1101/2021.07.23.453468 — ecology — Posted on 2021-08-31
188 Selective cleavage of ncRNA and antiviral activity by human RNase2/EDN in a macrophage infection model
Lu, L.; Li, J.; Wei, R.; Guidi, I.; Cozzuto, L.; Ponomarenko, J.; Prats-Ejarque, G.; Boix, E.
10.1101/2021.08.30.458223 — cell biology — Posted on 2021-08-31
190 Toxoplasma gondii GRA28 is required for placenta-specific induction of the regulatory chemokine CCL22 in human and mouse.
Rudzki, E. N.; Ander, S. E.; Coombs, R. S.; Alrubaye, H. S.; Cabo, L. F.; Blank, M. L.; Gutierrez-Melo, N.; Dubey, J.; Coyne, C. B.; Boyle, J. P.
10.1101/2020.10.14.335802 — microbiology — Posted on 2021-08-31
192 Intrinsic variation in the vertically transmitted insect-specific core virome of Aedes aegypti
Coatsworth, H.; Bozic, J.; Carrillo, J.; Buckner, E. A.; Rivers, A. R.; Dinglasan, R. R.; Mathias, D. K.
10.1101/2021.08.30.458191 — microbiology — Posted on 2021-08-31
195 CryoEM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition
Shaban, N.; Yan, R.; Shi, K.; Moraes, S.; Cheng, A.; Carpenter, M.; McLellan, J. S.; Zhiheng, Y.; Harris, R.
10.1101/2021.08.30.458246 — microbiology — Posted on 2021-08-31
197 Global distribution of anaerobic dichloromethane degradation potential
Murdoch, R. W.; Chen, G.; Kara Murdoch, F.; Mack, E. E.; Villalobos Solis, M. I.; Hettich, R.; Loeffler, F. E.
10.1101/2021.08.30.458270 — microbiology — Posted on 2021-08-31
199 A Regression Framework for Brain Network Distance Metrics
Tomlinson, C. E.; Laurienti, P. J.; Lyday, R. G.; Simpson, S. L.
10.1101/2021.02.26.432910 — neuroscience — Posted on 2021-08-31
202 Leaf area index estimation of even-aged oak (Quercus petraea) forests using in situ stand dendrometric parameters
Maxime, B.; Francois, C.; Lebourgeois, F.; Seynave, I.; Ningre, F.; Vincent, G.; Korboulewsky, N.; Perot, T.; Dufrene, E.; Perret, S.
10.1101/2021.08.05.454476 — ecology — Posted on 2021-08-31
203 Brain rhythms define distinct interaction networks with differential dependence on anatomy
Vezoli, J.; Vinck, M.; Bosman, C. A.; Bastos, A. M.; Lewis, C. M.; Kennedy, H.; Fries, P.
10.1101/2020.12.15.422902 — neuroscience — Posted on 2021-08-31
206 Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons
Yamagata, T.; Ogiwara, I.; Tatsukawa, T.; Otsuka, Y.; Mazaki, E.; Inoue, I.; Tokonami, N.; Hibi, Y.; Itohara, S.; Yamakawa, K.
10.1101/2021.03.31.437794 — neuroscience — Posted on 2021-08-31
208 Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging
Haider, A.; Xiao, Z.; Xia, X.; Chen, J.; Van, R. S.; Kuang, S.; Zhao, C.; Rong, J.; Shao, T.; Ramesh, P.; Aravind, A.; Shao, Y.; Ran, C.; Young, L.; Liang, S. H.
10.1101/2021.02.09.430516 — pharmacology and toxicology — Posted on 2021-08-31
209 A unique mode of nucleic acid immunity performed by a single multifunctional enzyme
Bari, S. M. N.; Chou-Zheng, L.; Howell, O.; Cater, K.; Dandu, V. S.; Thomas, A.; Aslan, B.; Hatoum-Aslan, A.
10.1101/776245 — microbiology — Posted on 2021-08-30
211 Biparatopic sybody constructs neutralize SARS-CoV-2 variants of concern and mitigate emergence of drug resistance
Walter, J. D.; Hutter, C. A. J.; Garaeva, A. A.; Scherer, M.; Zimmermann, I.; Wyss, M.; Rheinberger, J.; Ruedin, Y.; Earp, J. C.; Egloff, P.; Sorgenfrei, M.; Hürlimann, L.; Gonda, I.; Meier, G.; Remm, S.; Thavarasah, S.; van Geest, G.; Bruggman, R.; Zimmer, G.; Slotboom, D. J.; Paulino, C.; Plattet, P.; Seeger, M. A.
10.1101/2020.11.10.376822 — biochemistry — Posted on 2021-08-30
212 DNA end-resection in highly accessible chromatin produces a toxic break
van den Berg, J.; Joosten, S. E. P.; Kim, Y.; Manjon, A. G.; Krenning, L.; Koob, L.; Feringa, F. M.; Klompmaker, R.; van den Broek, B.; Jalink, K.; Zwart, W.; Medema, R. H.
10.1101/691857 — cell biology — Posted on 2021-08-30
213 Anti- SARS-CoV-2 Receptor Binding Domain Antibody Evolution after mRNA Vaccination
Cho, A.; Muecksch, F.; Schaefer-Babajew, D.; Wang, Z.; Finkin, S.; Gaebler, C.; Ramos, V.; Cipolla, M.; Mendoza, P.; Agudelo, M.; Bednarski, E.; DaSilva, J.; Shimeliovich, I.; Dizon, J.; Daga, M.; Millard, K.; Turroja, M.; Schmidt, F.; Zhang, F.; Ben Tanfous, T.; Jankovic, M.; Oliveira, T.; Gazumyan, A.; Caskey, M.; Bieniasz, P. D.; Hatziioannou, T.; Nussenzweig, M. C.
10.1101/2021.07.29.454333 — immunology — Posted on 2021-08-30
217 The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease
Melton, A.; Doyle-Meyers, L. A.; Blair, R. V.; Midkiff, C.; Melton, H. J.; Russell-Lodrigue, K.; Aye, P. P.; Schiro, F.; Fahlberg, M.; Szeltner, D.; Spencer, S.; Beddingfield, B. J.; Goff, K.; Golden, N.; Penney, T.; Picou, B.; Hensley, K.; Chandler, K. E.; Plante, J. A.; Plante, K. S.; Weaver, S. C.; Roy, C. J.; Hoxie, J. A.; Gao, H.; Montefiori, D. C.; Mankowski, J. L.; Bohm, R. P.; Rappaport, J.; Maness, N. J.
10.1101/2021.08.28.458047 — immunology — Posted on 2021-08-30
218 The control of transcriptional memory by stable mitotic bookmarking
Bellec, M.; Dufourt, J.; Hunt, G.; Lenden-Hasse, H.; Trullo, A.; Zine El Aabidine, A.; Lamarque, M.; Gaskill, M. M.; Faure-Gautron, H.; Mannervik, M.; Harrison, M.; Andrau, J.-C.; Favard, C.; Radulescu, O.; Lagha, M.
10.1101/2021.08.30.458146 — developmental biology — Posted on 2021-08-30
219 Hydrozoan sperm-specific H2B histone variants stabilize chromatin and block transcription without enhancing chromatin condensation
Torok, A.; Browne, M. J.; Vilar, J. C.; Patwal, I.; DuBuc, T. Q.; Febrimarsa, F.; Atcheson, E.; Flaus, A.; Frank, U.; Gornik, S. G.
10.1101/2021.08.30.458175 — developmental biology — Posted on 2021-08-30
220 EVALUATION OF STED SUPER-RESOLUTION IMAGE QUALITY BY IMAGE CORRELATION SPECTROSCOPY (QuICS)
Cerutti, E.; D'Amico, M.; Cainero, I.; Dellino, G. I.; Faretta, M.; Vicidomini, G.; Pelicci, P. G.; Bianchini, P.; Diaspro, A.; Lanzano', L.
10.1101/2021.08.30.457899 — biophysics — Posted on 2021-08-30
221 Cooperative Amyloid Fibre Binding and Disassembly by the Hsp70 disaggregase
Beton, J. G.; Monistrol, J.; Wentink, A.; Johnston, E. C.; Roberts, A. J.; Bukau, B.; Hoogenboom, B. W.; Saibil, H. R.
10.1101/2021.08.29.458036 — biochemistry — Posted on 2021-08-30
222 Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Singh, R. K.; Soliman, A.; Guaitoli, G.; Störmer, E.; von Zweydorf, F.; Dal Maso, T.; Van Rillaer, L.; Schmidt, S. H.; Chatterjee, D.; Pardon, E.; Knapp, S.; Kennedy, E. J.; Steyaert, J.; Herberg, F. W.; Kortholt, A.; Gloeckner, C. J.; Versees, W.
10.1101/2021.08.30.458082 — biochemistry — Posted on 2021-08-30
223 Biosynthetic gene cluster profiling predicts the positive association between antagonism and phylogeny in Bacillus
Xia, L.; Miao, Y.; Cao, A.; Liu, Y.; Liu, Z.; Sun, X.; Xue, Y.; Xu, Z.; Xun, W.; Shen, Q.; Zhang, N.; Zhang, R.
10.1101/2021.08.29.457868 — ecology — Posted on 2021-08-30
224 Local biodiversity change reflects interactions among changing abundance, evenness and richness
Blowes, S.; Daskalova, G. N.; Dornelas, M.; Engel, T.; Gotelli, N. J.; Magurran, A.; Martins, I. S.; McGill, B.; McGlinn, D.; Sagouis, A.; Shimadzu, H.; Supp, S. R.; Chase, J.
10.1101/2021.08.29.458087 — ecology — Posted on 2021-08-30
226 Structure modeling hints at a granular organization of the Vertebrate Golgi ribbon
Page, K.; McCormack, J.; Lopes-da-Silva, M.; Patella, F.; Harrison-Lavoie, K.; Burden, J. J.; Quah, Y.-Y. B.; Scaglioni, D.; Ferraro, F.; Cutler, D.
10.1101/2021.08.30.458089 — cell biology — Posted on 2021-08-30
227 Exo1-protected DNA nicks direct crossover formation in meiosis
Gioia, M.; Payero, L.; Pannafino, G.; Chen, J. J.; Salim, S.; Fajith, G.; Farnaz, A. F.; Momoh, S.; Scotland, M.; Raghavan, V.; Manhart, C.; Shinohara, A.; Nishant, K. T.; Alani, E.
10.1101/2021.08.29.458102 — molecular biology — Posted on 2021-08-30
230 Dietary methionine restriction impairs anti-tumor immunity through gut microbiota
Ji, M.; Xu, X.; Xu, Q.; Xu, X.; Azcarate-Peril, M. A.; Wu, X.; Liu, J.; Locasale, J. W.; Li, J.-L.; Shats, I.; Li, X.
10.1101/2021.08.27.457955 — cancer biology — Posted on 2021-08-30
233 Screening by deep sequencing reveals mediators of miRNA tailing in C. elegans
Vieux, K.-F.; Prothro, K. P.; Kelley, L. H.; Maine, E. M.; Veksler-Lublinsky, I. I.; McJunkin, K.
10.1101/2021.01.11.426275 — molecular biology — Posted on 2021-08-30
236 Sensory computations in the cuneate nucleus of macaques
Suresh, A. K.; Greenspon, C. M.; He, Q.; Rosenow, J. M.; Miller, L. E.; Bensmaia, S. J.
10.1101/2021.07.28.454185 — neuroscience — Posted on 2021-08-30
238 The OPAQUE1/DISCORIDA2 myosin XI is required for phragmoplast guidance during asymmetric cell division in maize
Nan, Q.; Liang, H.; Mendoza, J.; Liu, L.; Fulzele, A.; Wright, A. J.; Bennett, E. J.; Rasmussen, C.; Facette, M. R.
10.1101/2021.08.29.458084 — plant biology — Posted on 2021-08-30
239 Fluorescence lifetime imaging as an in situ and label-free readout for the chemical composition of lignin
Escamez, S.; Terryn, C.; Gandla, M. L.; Yassin, Z.; Scheepers, G.; Nasholm, T.; Sundman, O.; Jonsson, L. J.; Lundberg-Felten, J.; Tuominen, H.; Niittyla, T.; Paes, G.
10.1101/2021.08.26.457748 — plant biology — Posted on 2021-08-30
242 Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation
Baur, B. A.; Shin, J.; Schreiber, J.; Zhang, S.; Zhang, Y.; Manjunath, M.; Song, J. S.; Noble, W. S.; Roy, S.
10.1101/2021.08.29.458098 — bioinformatics — Posted on 2021-08-30
243 Genetic analysis of praziquantel response in schistosome parasites implicates a Transient Receptor Potential channel
Le Clec'h, W.; Chevalier, F. D.; Mattos, A. C. A.; Strickland, A.; Diaz, R.; McDew-White, M.; Rohr, C. M.; Kinung'hi, S.; Allan, F.; Webster, B. L.; Webster, J. P.; Emery, A. M.; Rollinson, D.; Garba Djirmay, A.; Al Mashikhi, K. M.; Al Yafae, S.; Idris, M. A.; Mone, H.; Mouahid, G.; LoVerde, P.; Marchant, J.; Anderson, T. J. C.
10.1101/2021.06.09.447779 — genetics — Posted on 2021-08-30
244 Policy-relevant indicators for invasive alien species assessment and reporting
McGeoch, M. A.; Arle, E.; Belmaker, J.; Buba, Y.; Clarke, D. A.; Essl, F.; Garcia-Berthou, E.; Groom, Q.; Henriksen, M. V.; Jetz, W.; Kuhn, I.; Lenzner, B.; Meyer, C.; Pagad, S.; Pili, A.; Roige, M.; Seebens, H.; Tingley, R.; Vicente, J. R.; Wilson, J. R.; Winter, M.
10.1101/2021.08.26.457851 — ecology — Posted on 2021-08-30
247 Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation through N-formyl peptide receptor 2 in a chronic murine model of Chagas disease
Carrillo, I.; Rabelo, R.; Barbosa, C.; Rates, M.; Fuentes-Retamal, S.; Gonzalez-Herrera, F.; Guzman-Rivera, D.; Quintero, H.; Kemmerling, U.; Castillo, C.; Machado, F. S.; Diaz-Araya, G.; Maya, J. D.
10.1101/2021.08.17.456695 — microbiology — Posted on 2021-08-30
254 Comparing the efficiency of monofilament and traditional nets for capturing bats
Chaves Ramirez, S.; Castillo Salazar, C.; Sanchez Chavarria, M.; Solis Hernandez, H.; Chaverri, G.
10.1101/2021.08.28.458045 — zoology — Posted on 2021-08-30
261 Differential Binding Kinetics for Evaluating Immune Checkpoint Inhibitors in Serum
Wang, S. X.; Choudhury, K.; Yao, D.; Yu, H.; Kantor, A.; Osterfeld, S.; Saito, T.; Carbonell, M. L.
10.1101/2021.08.29.458058 — bioengineering — Posted on 2021-08-30
263 Recurrent allopolyploidization events diversify eco-physiological traits in marsh orchids
Wolfe, T. M.; Balao, F.; Trucchi, E.; Bachmann, G.; Gu, W.; Baar, J.; Hedren, M.; Weckwerth, W.; Leitch, A. R.; Paun, O.
10.1101/2021.08.28.458039 — evolutionary biology — Posted on 2021-08-30
264 The genetic population structure of Lake Tanganyika's Lates species flock, an endemic radiation of pelagic top predators
Rick, J. A.; Junker, J.; Kimirei, I. A.; Sweke, E. A.; Mosille, J. B.; Dinkel, C.; Mwaiko, S.; Seehausen, O.; Wagner, C. E.
10.1101/2021.04.23.441176 — evolutionary biology — Posted on 2021-08-30
265 Metabolic regulation of species-specific developmental rates
Diaz-Cuadros, M.; Miettinen, T. P.; Sheedy, D.; Diaz-Garcia, C. M.; Gapon, S.; Hubaud, A.; Yellen, G.; Manalis, S. R.; Oldham, W.; Pourquie, O.
10.1101/2021.08.27.457974 — developmental biology — Posted on 2021-08-30
266 Systemic delivery of a CXCR4-CXCL12 signaling inhibitor encapsulated in synthetic protein nanoparticles for glioma immunotherapy
Alghamri, M. S.; Banerjee, K.; Mujeeb, A. A.; Taher, A.; Thalla, R.; McClellan, B. L.; Varela, M. L.; Stamatovic, S. M.; Martinez-Revollar, G.; Andjelkovic-Zochowska, A.; Gregory, J. V.; Kadiyala, P.; Calinescu, A.; Jimenez, J. A.; Apfelbaum, A. A.; Lawlor, E. R.; Carney, S.; Comba, A.; Faisal, S. M.; Barissi, M.; Edwards, M.; Appelman, H.; Olin, M. R.; Lahann, J.; Lowenstein, P. R.; Castro, M. G.
10.1101/2021.08.27.457953 — cell biology — Posted on 2021-08-30
268 Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes
Liu, Y.; Tao, W.; Zhang, Y.; Nie, H.; Hou, Z.; Zhang, J.; Yang, Z.; Wang, J.; Lu, F.; Wu, K.
10.1101/2021.08.29.458073 — developmental biology — Posted on 2021-08-30
269 Endothelial integration of mechanosensory signals by the spectrin cytoskeleton
Mylvaganam, S.; Yusuf, B.; Li, R.; Lu, C.-Y.; Robinson, L. A.; Freeman, S. A.; Grinstein, S.
10.1101/2021.08.29.458104 — cell biology — Posted on 2021-08-30
271 Prolonged and distributed processing of facial identity in the human brain
Stecher, R.; Muukkonen, I.; Salmela, V. R.; Rostalski, S.-M.; Ambrus, G. G.; Kovacs, G.
10.1101/2021.06.23.449599 — neuroscience — Posted on 2021-08-30
272 Consensus tandem tetratricopeptide repeat proteins are complex superhelical nanosprings
Synakewicz, M.; Eapen, R.; Perez-Riba, A.; Bauer, D.; Weissl, A.; Fischer, G.; Hyvonen, M.; Rief, M.; Itzhaki, L. S.; Stigler, J.
10.1101/2021.03.27.437344 — biophysics — Posted on 2021-08-30
273 Integrated gene landscapes uncover multi-layered roles of repressive histone marks during mouse CNS development
Mora, A.; Rakar, J.; Cobeta, I. M.; Yaghmaeian Salmani, B.; Starkenberg, A.; Thor, S.; Boden, M.
10.1101/2021.06.22.449386 — bioinformatics — Posted on 2021-08-30
275 Binary outcomes of enhancer activity underlie stable random monoallelic expression
Kissiov, D. U.; Ethell, A.; Chen, S.; Wolf, N. K.; Zhang, C.; Dang, S. M.; Jo, Y.; Madsen, K. N.; Paranjpe, I. D.; Lee, A. Y.; Chim, B.; Muljo, S. A.; Raulet, D. H.
10.1101/2021.08.27.457979 — molecular biology — Posted on 2021-08-30
276 Uncoupling of the Diurnal Growth Program by Artificial Genome Relaxation in Synechocystis sp. PCC 6803
Behle, A.; Dietsch, M.; Goldschmidt, L.; Murugathas, W.; Brandt, D.; Busche, T.; Kalinowski, J.; Ebenhoeh, O.; Axmann, I. M.; Machne, R.
10.1101/2021.07.26.453758 — microbiology — Posted on 2021-08-29
281 Structured proteins are abundant in unevolved sequence space
Tretyachenko, V.; Vymetal, J.; Neuwirthova, T.; Vondrasek, J.; Fujishima, K.; Hlouchova, K.
10.1101/2021.08.29.458031 — synthetic biology — Posted on 2021-08-29
282 Conserved secreted effectors determine endophytic growth and multi-host plant compatibility in a vascular wilt fungus
Redkar, A.; Sabale, M.; Schudoma, C.; Zechmann, B.; Gupta, Y. K.; Lopez-Berges, M. S.; Venturini, G.; Gimenez Ibanez, S.; Turra, D.; Solano, R.; Di Pietro, A.
10.1101/2021.08.29.457830 — plant biology — Posted on 2021-08-29
283 ATM phosphorylates PP2A subunit A resulting in nuclearexport and spatiotemporal regulation of the DNA damageresponse
Sule, A.; Golding, S. E.; Farhan, S. F.; Watson, J.; Ahmed, M. H.; Kellogg, G. E.; Bernas, T.; Koebley, S.; Reed, J. C.; Povirk, L. F.; Valerie, K.
10.1101/2021.08.29.458108 — cancer biology — Posted on 2021-08-29
285 The Need for Transfer Learning in CRISPR-Cas Off-Target Scoring
Kota, P. K.; Pan, Y.; Vu, H.-A.; Cao, M.; Baraniuk, R. G.; Bao, G.
10.1101/2021.08.28.457846 — bioinformatics — Posted on 2021-08-29
286 Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer's disease
KANESHIRO, N.; MASATO, K.; IMAOKA, R.; IKEDA, A.; KAMIKUBO, Y.; HASHIMOTO, T.; IWATSUBO, T.; SAKURAI, T.; UEHARA, T.; TAKASUGI, N.
10.1101/2021.07.30.454423 — biochemistry — Posted on 2021-08-29
290 Adipocyte-Specific Ablation Of PU.1 Promotes Energy Expenditure and Ameliorates Metabolic Syndrome In Aging Mice
Chen, K.; De Angulo, A.; Guo, X.; More, A.; Ochsner, S.; Lopez, E.; Saul, D.; Sun, Y.; McKenna, N.; Tong, Q.
10.1101/2021.08.29.458103 — cell biology — Posted on 2021-08-29
292 Single-embryo phosphoproteomics reveals the importance of intrinsic disorder in cell cycle dynamics
Valverde, J. M.; Dubra, G.; van den Toorn, H.; van Mierlo, G.; Vermeulen, M.; Heck, A. J. R.; Knipscheer, P.; Krasinska, L.; Fisher, D.; Altelaar, M.
10.1101/2021.08.29.458076 — cell biology — Posted on 2021-08-29
297 Implication of the cellular factor CTCF in the regulation of Bovine Leukemia Virus latency and tridimensional chromatin organization
Bellefroid, M.; Rodari, A.; Galais, M.; Krijger, P.; Nestola, L.; Plant, E.; Cristinelli, S.; Vos, E.; Vanhulle, C.; Van Driessche, B.; Ait Ammar, A.; Ciuffi, A.; de Laat, W.; Van Lint, C.
10.1101/2021.08.28.457911 — molecular biology — Posted on 2021-08-29
299 Rethinking symbiotic metabolism: trophic strategies in the microbiomes of different sponge species
Burgsdorf, I.; Sizikov, S.; Squatrito, V.; Britstein, M.; Slaby, B. M.; Cerrano, C.; Handley, K. M.; Steindler, L.
10.1101/2021.08.28.458021 — microbiology — Posted on 2021-08-29
300 HIV-1 Mutants that Escape the Cytotoxic T-Lymphocytes are Defective in Viral DNA Integration
Balasubramaniam, M.; Thapa, S.; Davids, B.-O.; Bryer, A.; Xu, C.; Shi, J.; Aiken, C.; Pandhare, J.; Perilla, J. R.; Dash, C.
10.1101/2021.08.29.458043 — microbiology — Posted on 2021-08-29
302 Stochastic microbiome assembly depends on context
Jones, E. W.; Carlson, J. M.; Sivak, D. A.; Ludington, W. B.
10.1101/2021.08.29.458111 — microbiology — Posted on 2021-08-29
304 Grid-cell modules remain coordinated when neural activity is dissociated from external sensory cues
Waaga, T.; Agmon, H.; Normand, V. A.; Nagelhus, A.; Gardner, R. J.; Moser, M.-B.; Moser, E. I.; Burak, Y.
10.1101/2021.08.29.458100 — neuroscience — Posted on 2021-08-29
307 Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors.
Dawson, J. C.; Munro, A.; Macleod, K.; Muir, M.; Timpson, P.; Williams, R.; Frame, M. C.; Brunton, V.; Carragher, N. O.
10.1101/2021.08.27.457893 — cancer biology — Posted on 2021-08-29
309 Spike mimicry of thrombopoietin may induce thrombocytopenia in COVID-19
Nunez-Castilla, J.; Stebliankin, V.; Baral, P.; Balbin, C. A.; Sobhan, M.; Cickovski, T.; Mondal, A. M.; Narasimhan, G.; Chapagain, P.; Mathee, K.; Siltberg-Liberles, J.
10.1101/2021.08.10.455737 — bioinformatics — Posted on 2021-08-29
310 Hydrogel-based slow release of a receptor-binding domain subunit vaccine elicits neutralizing antibody responses against SARS-CoV-2
Gale, E. C.; Powell, A. E.; Roth, G. A.; Meany, E. L.; Yan, J.; Ou, B. S.; Grosskopf, A. K.; Adamska, J.; Picece, V. C. T. M.; d'Aquino, A. I.; Pulendran, B.; Kim, P. S.; Appel, E.
10.1101/2021.03.31.437792 — bioengineering — Posted on 2021-08-29
311 High-quality Arabidopsis thaliana Genome Assembly with Nanopore and HiFi Long Reads
Wang, B.; Yang, X.; Jia, Y.; Xu, Y.; Jia, P.; Dang, N.; Wang, S.; Xu, T.; Zhao, X.; Gao, S.; Dong, Q.; Ye, K.
10.1101/2021.06.08.447650 — genomics — Posted on 2021-08-29
312 Direct RNA sequencing reveals SARS-CoV-2 m6A sites and possible differential DRACH motif methylation among variants
Campos, J. H.; Maricato, J. T.; Braconi, C. T.; Antoneli, F.; Janini, L. M. R.; Briones, M. R.
10.1101/2021.08.24.457397 — genomics — Posted on 2021-08-29
313 Development of a flexible split prime editor using truncated reverse transcriptase
Zheng, C.; Liang, S.-q.; Liu, B.; Liu, P.; Kwan, S.-Y.; Wolfe, S.; Xue, W.
10.1101/2021.08.26.457801 — genetics — Posted on 2021-08-29
314 Intra-host SARS-CoV-2 evolution in the gut of mucosally-infected Chlorocebus aethiops (African green monkeys)
Rowe, L. A.; Beddingfield, B. J.; Goff, K.; Killeen, S. Z.; Chirichella, N. R.; Melton, A.; ROY, C. J.; Maness, N. J.
10.1101/2021.08.22.457295 — microbiology — Posted on 2021-08-29
321 Dual avatars of E. coli grxB encoded Glutaredoxin 2 perform ascorbate recycling and ion channel activities
Nellootil Sreekumar, S.; Das, B. K.; Raina, R.; Puthumadathil, N.; Udinia, S.; kumar, A.; Sahoo, S.; Ravichandran, P.; Kumar, S.; Ray, P.; Kumar, D.; Chandele, A.; Mahendran, K. R.; Arockiasamy, A.
10.1101/2021.08.28.458008 — biochemistry — Posted on 2021-08-29
324 Tip growth in the brown alga Ectocarpus is controlled by a RHO-GAP-BAR domain protein independently from F-actin organisation
Nehr, Z.; Chenivesse, S.; Billoud, B.; Genicot, S.; Desban, N.; Theodorou, I.; Nasir, A.; Le Bail, A.; Rabille, H.; Godfroy, O.; Katsaros, C.; Charrier, B.
10.1101/2021.08.28.458042 — developmental biology — Posted on 2021-08-28
326 Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding
Furniss, R. C. D.; Kaderabkova, N.; Barker, D.; Bernal, P.; Maslova, E.; Antwi, A. A. A.; McNeil, H. E.; Pugh, H. L.; Dortet, L.; Blair, J. M. A.; Larrouy-Maumus, G.; McCarthy, R. R.; Gonzalez, D.; Mavridou, D. A. I.
10.1101/2021.08.27.457985 — microbiology — Posted on 2021-08-28
329 TopoRoot: A method for computing hierarchy and fine-grained traits of maize roots from X-ray CT images
Zeng, D.; Li, M.; Jiang, N.; Ju, Y.; Schreiber, H.; Chambers, E.; Letscher, D.; Ju, T.; Topp, C. N.
10.1101/2021.08.24.457522 — plant biology — Posted on 2021-08-28
330 Balancing growth amidst salinity stress-lifestyle perspectives from the extremophyte model Schrenkiella parvula
Tran, K.-N.; Pantha, P.; Wang, G.; Kumar, N.; Wijesinghege, C.; Hong, H.; Johnson, J.; Kelt, R.; Matherne, M. G.; Clement, A.; Crain, C.; Tran, D.; Oh, D.-H.; Adhikari, P.; Foroozani, M.; Finnegan, P.; Longstreth, D.; Larkin, J. C.; Smith, A. P.; Dassanayake, M.
10.1101/2021.08.27.457575 — plant biology — Posted on 2021-08-28
332 Membrane cholesterol interferes with tyrosine phosphorylation but facilitates the clustering and signal transduction of EGFR
Hiroshima, M.; Abe, M.; Tomishige, N.; Hullin-Matsuda, F.; Makino, A.; Ueda, M.; Kobayashi, T.; Sako, Y.
10.1101/2021.08.28.457965 — biophysics — Posted on 2021-08-28
336 Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism
Hicks, K. G.; Cluntun, A. A.; Schubert, H. L.; Hackett, S. R.; Berg, J. A.; Leonard, P. G.; Ajalla Aleixo, M. A.; Blevins, A.; Barta, P.; Tilley, S.; Fogarty, S.; Winter, J. M.; Ahn, H.-C.; Allen, K. N.; Block, S.; Cardoso, I. A.; Ding, J.; Dreveny, I.; Gasper, C.; Ho, Q.; Matsuura, A.; Palladino, M. J.; Prajapati, S.; Sun, P.; Tittmann, K.; Tolan, D. R.; Unterlass, J.; VanDemark, A. P.; Vander Heiden, M. G.; Webb, B. A.; Yun, C.-H.; Zhap, P.; Hill, C. P.; Nonato, M. C.; Muller, F. L.; Gottschling, D. E.; Cox, J. E.; Rutter, J.
10.1101/2021.08.28.458030 — biochemistry — Posted on 2021-08-28
337 Bacterial glycyl tRNA synthetase offers glimpses of ancestral protein topologies
Dimas-Torres, J.-U.; Rodriguez-Hernandez, A.; Valencia-Sanchez, M.-I.; Campos-Chavez, E.; Godinez-Lopez, V.; Rodriguez-Chamorro, D.-E.; Grotli, M.; Fleming, C.; Hernandez-Gonzalez, A.; Arciniega, M.; Torres-Larios, A.
10.1101/2021.08.20.456953 — evolutionary biology — Posted on 2021-08-28
340 Local mechanical stimuli shape tissue growth in vertebrate joint morphogenesis
Comellas, E.; Farkas, J. E.; Kleinberg, G.; Lloyd, K.; Mueller, T.; Duerr, T. J.; Munoz, J. J.; Monaghan, J. R.; Shefelbine, S. J.
10.1101/2021.08.28.458034 — developmental biology — Posted on 2021-08-28
344 The adaptive role of cell death in yeast communities stressed with macrolide antifungals
Kireeva, N.; Sokolov, S. S.; Smirnova, E. A.; Galkina, K. V.; Severin, F. F.; Knorre, D. A.
10.1101/2021.08.27.457932 — microbiology — Posted on 2021-08-28
345 Cerebrospinal fluid outflow through skull channels instructs cranial hematopoiesis
Pulous, F. E.; Cruz-Hernandez, J. C.; Yang, C.; Kaya, Z.; Wojtkiewicz, G.; Capen, D.; Brown, D.; Wu, J. W.; Vinego, C.; Yamazoe, M.; Grune, J.; Schloss, M. J.; Rohde, D.; Richter, D.; McAlpine, C. S.; Panizzi, P.; Weissleder, R.; Kim, D.-E.; Swirski, F. K.; Lin, C. P.; Moskowitz, M. M.; Nahrendorf, M.
10.1101/2021.08.27.457954 — immunology — Posted on 2021-08-28
347 Generation and validation of a CRF1:Cre transgenic rat: The role of central amygdala CRF1 in nociception and anxiety-like behavior
Weera, M. M.; Agoglia, A. E.; Douglass, E. A.; Jiang, Z.; Rajamanikam, S.; Shackett, R. S.; Herman, M. A.; Justice, N. J.; Gilpin, N. W.
10.1101/2021.02.23.432551 — neuroscience — Posted on 2021-08-28
348 Intrinsic regulators of the action potential waveform control dopamine release to shape behavior
Juarez, B.; Kong, M.-S.; Jo, Y. S.; Elum, J. E.; Yee, J. X.; Ng-Evans, S.; Cline, M.; Hunker, A. C.; Baird, M. A.; Quinlan, M. A.; Mendez, A.; Goodwin, N.; Soden, M. E.; Zweifel, L.
10.1101/2021.08.27.457972 — neuroscience — Posted on 2021-08-28
351 Quantification of circadian interactions and protein abundance defines a mechanism for operational stability of the circadian clock
Bagnall, J. S.; Koch, A. A.; Smyllie, N. J.; Begley, N.; Adamson, A.; Fribourgh, J. L.; Spiller, D. G.; Meng, Q.-J.; Partch, C. L.; Strimmer, K.; House, T. A.; Hastings, M. H.; Loudon, A. S. I.
10.1101/2021.08.27.456017 — systems biology — Posted on 2021-08-28
353 Cap analysis of gene expression (CAGE) sequencing reveals alternative promoter usage in complex disease
Dahale, S.; Ruiz-Orera, J.; Silhavy, J.; Hubner, N.; van Heesch, S.; Pravenec, M.; Atanur, S. S.
10.1101/2021.08.28.458014 — bioinformatics — Posted on 2021-08-28
354 Modeling miRNA-driven post-transcriptional regulation by using exon-intron split analysis (EISA) in pigs
Marmol-Sanchez, E.; Cirera, S.; Zingaretti, L.; Jacobsen, M. J.; Ramayo-Caldas, Y.; Jorgensen, C. B.; Fredholm, M.; Cardoso, T. F.; Quintanilla, R.; Amills, M.
10.1101/2021.07.14.452370 — genomics — Posted on 2021-08-28
355 Vectofusin-1 based T-cell transduction approach for developing murine CAR-T cells for cancer.
Patel, R.; Devashish, K.; Singh, S.; Nath, P. R.; Gohel, D. M.; Prasad, R.; Singh, M.; Saini, N. Y.
10.1101/2021.08.28.458011 — genetics — Posted on 2021-08-28
356 Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer's disease.
Salvadores, N.; Moreno, I.; Gamez, N.; Quiroz, G.; Vegas, L.; Escandon, M.; Jimenez, S.; Vitorica, J.; Gutierrez, A.; Soto, C.; Court, F.
10.1101/2021.08.27.457960 — cell biology — Posted on 2021-08-28
358 Binary outcomes of enhancer activity underlie stable random monoallelic expression
Kissiov, D. U.; Ethell, A.; Chen, S.; Wolf, N. K.; Zhang, C.; Dang, S. M.; Jo, Y.; Madsen, K. N.; Paranjpe, I. D.; Lee, A. Y.; Chim, B.; Raulet, D.
10.1101/2021.08.27.457979 — molecular biology — Posted on 2021-08-28
362 Advanced Age Has Dissociable Effects on Hippocampal CA1 and CA3 Ripples
DiCola, N. M.; Lacy, A. L.; Bishr, O. J.; Kimsey, K. M.; Whitney, J. L.; Lovett, S. D.; Burke, S. N.; Maurer, A. P.
10.1101/2021.08.27.457373 — animal behavior and cognition — Posted on 2021-08-28
363 Fear of parasitism affects the functional role of ecosystem engineers
Mouritsen, K. N.; Dalsgaard, N. P.; Flensburg, S. B.; Madsen, J. C.; Selbach, C.
10.1101/2021.08.27.457894 — ecology — Posted on 2021-08-28
364 The STAT5-IRF4-BATF pathway drives heightened epigenetic remodeling in naïve CD4+ T cell responses of older adults
Zhang, H.; Jadhav, R. R.; Cao, W.; Goronzy, I. N.; Jin, J.; Greenleaf, W. J.; Weyand, C. M.; Goronzy, J.
10.1101/2021.08.27.457205 — immunology — Posted on 2021-08-28
365 Retinoschisin deficiency induces persistent aberrant waves of activity affecting neuroglial signaling in the retina
Eleftheriou, C. G.; Corona, C.; Khattak, S.; Ivanova, E.; Bianchimano, P.; Liu, Y.; Sun, D.; Singh, R.; Batoki, J. C.; McAnany, J. J.; Peachey, N. S.; Romano, C.; Sagdullaev, B. T.
10.1101/2021.08.26.457777 — neuroscience — Posted on 2021-08-28
366 Alterations in rhythmic and non-rhythmic resting-state EEG activity and their link to cognition in older age
Cesnaite, E.; Steinfath, T. P.; Idaji, M. J.; Stephani, T.; Kumral, D.; Haufe, S.; Sander, C.; Hensch, T.; Hegerl, U.; Riedel-Heller, S.; Roehr, S.; Schroeter, M. L.; Witte, V.; Villringer, A.; Nikulin, V.
10.1101/2021.08.26.457768 — neuroscience — Posted on 2021-08-28
367 Preclinical models of human multiple myeloma subgroups
Winkler, W.; Farre Diaz, C.; Blanc, E.; Napieczynska, H.; Langner, P.; Werner, M.; Walter, B.; Wollert-Wulf, B.; Yasuda, T.; Heuser, A.; Beule, D.; Mathas, S.; Anagnostopoulos, I.; Rosenwald, A.; Rajewsky, K.; Janz, M.
10.1101/2021.08.28.458010 — cancer biology — Posted on 2021-08-28
368 Dynamic and Facilitated Binding of Topoisomerase Accelerates Topological Relaxation
Michieletto, D.; Fosado, Y. A. G.; Melas, E.; Baiesi, M.; Tubiana, L.; Orlandini, E.
10.1101/2021.08.28.458016 — biophysics — Posted on 2021-08-28
371 Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels
Linville, R. M.; Sklar, M. B.; Grifno, G. N.; Nerenberg, R. F.; Zhou, J.; Ye, R.; DeStefano, J. G.; Guo, Z.; Jha, R.; Jamieson, J. J.; Zhao, N.; Searson, P. C.
10.1101/2021.08.27.457975 — bioengineering — Posted on 2021-08-28
374 Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria
Wang, Y.; Chen, X.; Spengler, K.; Terberger, K.; Boehm, M.; Appel, J.; Barske, T.; Timm, S.; Battchikova, N.; Hagemann, M.; Gutekunst, K.
10.1101/2021.08.27.457892 — evolutionary biology — Posted on 2021-08-28
376 Temporally dynamic antagonism between transcription and chromatin compaction controls stochastic photoreceptor specification
Voortman, L.; Anderson, C.; Urban, E.; Yuan, M.; Tran, S.; Neuhaus-Follini, A.; Derrick, J.; Gregor, T.; Johnston, R. J.
10.1101/2021.08.27.457982 — developmental biology — Posted on 2021-08-28
377 Renal Interstitial Cells Promote Nephron Regeneration by Secreting Prostaglandin E2
Liu, X.; Yu, T.; Tan, X.; Jin, D.; Zhang, J.; Zhang, Y.; Liao, S.; Yang, W.; Zhao, J.; Zhong, T.; Liu, C.
10.1101/2021.08.27.457936 — developmental biology — Posted on 2021-08-28
378 Molecular Basis for CPC-Sgo1 Interaction: Implications for Centromere Localisation and Function of the CPC
Abad, M. A.; Gupta, T.; Hadders, M. A.; Meppelink, A.; Wopken, J. P.; Blackburn, E.; Zou, J.; Buzuk, L.; Kelly, D. A.; McHugh, T.; Rappsilber, J.; Lens, S. M.; Jeyaprakash, A. A.
10.1101/2021.08.27.457910 — cell biology — Posted on 2021-08-28
379 The connecting cilium inner scaffold provides a structural foundation to maintain photoreceptor integrity
Mercey, O.; Kostic, C.; Bertiaux, E.; Giroud, A.; Sadian, Y.; Chang, N.; Arsenijevic, Y.; Guichard, P.; Hamel, V.
10.1101/2021.08.27.457921 — cell biology — Posted on 2021-08-28
380 MRI-Visible Perivascular Space (PVS) Changes with Long-Duration Spaceflight
Hupfeld, K.; Richmond, S.; McGregor, H.; Schwartz, D.; Luther, M.; Beltran, N.; Kofman, I.; De Dios, Y.; Riascos, R.; Wood, S.; Bloomberg, J.; Mulavara, A.; Silbert, L.; Iliff, J.; Seidler, R.; Piantino, J.
10.1101/2021.08.26.457870 — neuroscience — Posted on 2021-08-28
381 MS-driven metabolic alterations are recapitulated in iPSC-derived astrocytes
Ghirotto, B.; Oliveira, D. F.; Cipelli, M.; Basso, P. J.; de Lima, J.; Breda, C. N. S.; Ribeiro, H. C.; Silva, C. C. C.; Hiyane, M. I.; Caldini, E. G.; Sussulini, A.; Kowaltowski, A. J.; Oliveira, E. M. L.; Zatz, M.; Camara, N. O. S.
10.1101/2021.08.27.457853 — neuroscience — Posted on 2021-08-28
383 The brain uses invariant dynamics to generalize outputs across movements
Athalye, V. R.; Khanna, P.; Gowda, S.; Orsborn, A. L.; Costa, R. M.; Carmena, J. M.
10.1101/2021.08.27.457931 — neuroscience — Posted on 2021-08-28
388 A Multi-Omics Human Liver Organoid Screening Platform for DILI Risk Prediction
Zhang, C. J.; O'Meara, M. J.; Meyer, S. R.; Huang, S.; Capeling, M. M.; Ferrer-Torres, D.; Childs, C. J.; Spence, J. R.; Fontana, R. J.; Sexton, J. Z.
10.1101/2021.08.26.457824 — pharmacology and toxicology — Posted on 2021-08-28
389 The mechanical regulation of RNA binding protein hnRNPC in the failing heart
Martino, F.; Perestrelo, A. R.; Hejret, V.; Varadarajan, N. M.; Durikova, H.; Horvath, V.; Cavalieri, F.; Caruso, F.; Albihlal, W. S.; Gerber, A. P.; O'Connell, M. A.; Vanacova, S.; Pagliari, S.; Forte, G.
10.1101/2021.08.27.457906 — pathology — Posted on 2021-08-28
390 Aberrant accumulation of NIK promotes tumorigenicity by dysregulating post-translational modifications in breast cancer
Hayashi, Y.; Nakayama, J.; Yamamoto, M.; Maekawa, M.; Watanabe, S.; Higashiyama, S.; Inoue, J.-i.; Yamamoto, Y.; Semba, K.
10.1101/2021.08.27.457878 — cancer biology — Posted on 2021-08-28
391 Stereo-specific Lasofoxifene Derivatives Reveal the Interplay between Estrogen Receptor Alpha Stability and Antagonistic Activity in ESR1 Mutant Breast Cancer Cells
Hosfield, D. J.; Weber, S.; Li, N.-S.; Suavage, M.; Sullivan, E.; Nduwke, E.; Han, R.; Cush, S.; Laine, M.; Mader, S. C.; Greene, G. L.; Fanning, S. W.
10.1101/2021.08.27.457901 — cancer biology — Posted on 2021-08-28
395 Redesigning the Eterna100 for the Vienna 2 folding engine
Koodli, R. V.; Rudolfs, B.; Wayment-Steele, H. K.; Eterna Structure Designers, ; Das, R.
10.1101/2021.08.26.457839 — bioinformatics — Posted on 2021-08-28
396 dsMTL - a computational framework for privacy-preserving, distributed multi-task machine learning
Cao, H.; Zhang, Y.; Baumbach, J.; Burton, P. R.; Dwyer, D.; Koutsouleris, N.; Matschinske, J.; Marcon, Y.; Rajan, S.; Rieg, T.; Ryser-Welch, P.; Späth, J.; The COMMITMENT consortium, ; Herrmann, C.; Schwarz, E.
10.1101/2021.08.26.457778 — bioinformatics — Posted on 2021-08-28
397 Whole-tissue deconvolution and scRNAseq analysis identify altered endometrial cellular compositions and functionality associated with endometriosis
Bunis, D.; Wang, W.; Vallve-Juanico, J.; Houshdaran, S.; Sen, S.; Soltane, I. B.; Kosti, I.; Vo, K. C.; Irwin, J.; Giudice, L. C.; Sirota, M.
10.1101/2021.08.27.457966 — bioinformatics — Posted on 2021-08-28
398 The Practical Haplotype Graph, a platform for storing and using pangenomes for imputation
Bradbury, P.; Casstevens, T.; Jensen, S. E.; Johnson, L. C.; Miller, Z. R.; Monier, B.; Romay, M. C.; Song, B.; Buckler, E. S.
10.1101/2021.08.27.457652 — bioinformatics — Posted on 2021-08-28
399 Benchmarking Computational Integration Methods for Spatial Transcriptomics Data
Li, Y.; Stanojevic, S.; He, B.; Jing, Z.; Huang, Q.; Kang, J.; Garmire, L.
10.1101/2021.08.27.457741 — bioinformatics — Posted on 2021-08-28
402 The Macromolecular MR Spectrum in Healthy Aging
Hui, S.; Gong, T.; Zoellner, H. J.; Song, Y.; Murali-Manohar, S.; Oeltzschner, G.; Mikkelsen, M.; Tapper, S.; Chen, Y.; Saleh, M.; Porges, E. C.; Chen, W.; Wang, G.; Edden, R. A. E.
10.1101/2021.08.27.457961 — bioengineering — Posted on 2021-08-28
407 Mechanistic basis for SNX27-Retromer coupling to ESCPE-1 in promoting endosomal cargo recycling.
Simonetti, B.; Guo, Q.; Gimenez-Andres, M.; Chen, K.-E.; Moody, E. R. R.; Evans, A. J.; Danson, C. M.; Williams, T. A.; Collins, B. M.; Cullen, P. J.
10.1101/2021.08.28.457928 — cell biology — Posted on 2021-08-28
410 A thalamo-centric neural signature for restructuring negative self-beliefs
Steward, T.; Kung, P.-H.; Davey, C. G.; Moffat, B. A.; Glarin, R. K.; Jamieson, A. J.; Felmingham, K. L.; Harrison, B. J.
10.1101/2021.08.26.457858 — neuroscience — Posted on 2021-08-28
412 Methylmalonic acid impairs cell respiration and glutamate uptake in C6 rat glioma cells
Costa, R. T.; Santos, M. B.; Alberto-Silva, C.; Carrettiero, D. C.; Ribeiro, C. A. J.
10.1101/2021.08.26.457835 — neuroscience — Posted on 2021-08-28
413 Highly sensitive genetically-encoded sensors for population and subcellular imaging of cAMP in vivo
Massengill, C. I.; Bayless-Edwards, L.; Ceballos, C. C.; Cebul, E. R.; Qin, M.; Whorton, M. R.; Ye, B.; Mao, T.; Zhong, H.
10.1101/2021.08.27.457999 — neuroscience — Posted on 2021-08-28
417 Transcriptomic mapping of the inter-individual variability of cellular stress response activation in primary human hepatocytes
Niemeijer, M.; Wiecek, W.; Huppelschoten, S.; Bouwman, P.; Baze, A.; Parmentier, C.; Richert, L.; Paules, R. S.; Bois, F. Y.; van de Water, B.
10.1101/2021.08.26.457742 — pharmacology and toxicology — Posted on 2021-08-28
418 Development and Characterization of a Weaned Pig Model of Shiga Toxin-Producing E. coli-Induced Gastrointestinal Disease
Boeckman, J. X.; Sprayberry, S.; Korn, A. M.; Suchodolski, J. S.; Paulk, C.; Genovese, K. J.; Rech, R. R.; Giarettta, P. R.; Blick, A.; Callaway, T.; Gill, J. J.
10.1101/2021.08.26.457881 — pathology — Posted on 2021-08-28
419 Structural dynamics of SARS-CoV-2 nucleocapsid protein induced by RNA binding
Ribeiro-Filho, H. V.; Jara, G. E.; Batista, F. A. H.; Schleder, G. R.; Tonoli, C. C.; Soprano, A. S.; Guimaraes, S. L.; Borges, A. C.; Cassago, A.; Bajgelman, M. C.; Marques, R. E.; Trivella, D. B. B.; Franchini, K. G.; Figueira, A. C. M.; Benedetti, C. E.; Lopes-de-Oliveira, P. S.
10.1101/2021.08.27.457964 — biophysics — Posted on 2021-08-28
422 A Wide-Field Micro-Computed Tomography Detector: Micron Resolution at Half-centimeter Scale
Yakovlev, M. A.; Vanselow, D. J.; Ngu, M. S.; Zaino, C. R.; Katz, S. R.; Ding, Y.; Parkinson, D.; Wang, S. Y.; Ang, K. C.; La Riviere, P. J.; Cheng, K. C.
10.1101/2021.08.27.457808 — bioinformatics — Posted on 2021-08-28
424 Comparative kinetic analysis of ascorbate (Vitamin-C) recycling dehydroascorbate reductases from plant and human.
Das, B. K.; kumar, A.; Nellootil Sreekumar, S.; Ponraj, K.; Gadave, K.; Kumar, S.; Achary, V. M. M.; Ray, P.; Reddy, M. K.; Arockiasamy, A.
10.1101/2021.08.28.458007 — biochemistry — Posted on 2021-08-28
428 Timing and magnitude of climate driven range shifts in transboundary fish stocks challenge their management
Palacios-Abrantes, J.; Frolicher, T.; Reygondeau, G.; Sumaila, R. U.; Tagliabue, A.; Wabnitz, C. C. C.; Cheung, W. W. L.
10.1101/2021.08.26.456854 — ecology — Posted on 2021-08-28
429 A novel analytical decoder of BOLD signals for dissociating latent neurobehavioral processes
Xiang, S.; Jia, T.; Xie, C.; Zhu, Z.; Kang, J.; Cheng, W.; Schumann, G.; Robbins, T.; Feng, J.
10.1101/2021.08.25.457728 — neuroscience — Posted on 2021-08-28
432 Extracellular matrix stiffness regulates degradation of the Hippo kinase MST2 via SCFβTrCP
Fiore, A. P. Z. P.; da Silva, A. M. R.; Ribeiro, H. V.; Manucci, A. C.; Ribeiro, P. d. F.; Silva Botelho, M. C.; Oliveira, P. S. L.; Pagano, M.; Bruni-Cardoso, A.
10.1101/2021.01.31.429078 — cell biology — Posted on 2021-08-28
433 Fluorescence lifetime imaging as an in situ and label-free readout for the chemical composition of lignin
Escamez, S.; Terryn, C.; Gandla, M. L.; Yassin, Z.; Scheepers, G.; Nasholm, T.; Sundman, O.; Jonsson, L. J.; Lundberg-Felten, J.; Tuominen, H.; Niittyla, T.; Paes, G.
10.1101/2021.08.26.457748 — plant biology — Posted on 2021-08-28
434 Dietary methionine restriction impairs anti-tumor immunity through gut microbiota
Li, M.; Xu, X.; Xu, Q.; Xu, X.; Azcarate-Peril, M. A.; Wu, X.; Liu, J.; Locasale, J. W.; Li, J.-L.; Shats, I.; Li, X.
10.1101/2021.08.27.457955 — cancer biology — Posted on 2021-08-28
436 Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models
Laufer, B. I.; Hasegawa, Y.; Zhang, Z.; Hogrefe, C. E.; Del Rosso, L. A.; Haapanen, L.; Hwang, H.; Bauman, M. D.; Van De Water, J. A.; Taha, A. Y.; Slupsky, C. M.; Golub, M. S.; Capitanio, J. P.; Vandevoort, C. A.; Walker, C. K.; LaSalle, J. M.
10.1101/2021.08.27.457952 — genomics — Posted on 2021-08-28
437 Methylation at CpG sites in genomes of aphid Acyrtosiphon pisum and its endosymbiont Buchnera
Clement, M.; Da Rocha, M.; Agnel, S.; Raddatz, G.; Robichon, A.; Bailly-Bechet, M.
10.1101/2021.08.26.457790 — genomics — Posted on 2021-08-28
442 Allele expression biases in mixed-ploid sugarcane accessions
Correr, F. H.; Furtado, A.; Garcia, A. A. F.; Henry, R. J.; Margarido, G. R. A.
10.1101/2021.08.26.457296 — genomics — Posted on 2021-08-28
448 Host lung environment limits Aspergillus fumigatus germination through a SskA-dependent signaling response
Kirkland, M. E.; Stannard, M.; Kowalski, C. H.; Mould, D. L.; Caffrey-Carr, A. K.; Temple, R. M.; Ross, B. S.; Lofgren, L. A.; Stajich, J. E.; Cramer, R. A.; Obar, J. J.
10.1101/2021.08.27.456493 — microbiology — Posted on 2021-08-28
450 Multiplex immunohistochemistry differences between Q fever and atherosclerotic abdominal aortic aneurysms indicate immune suppression
Cortenbach, K. R. G.; SCAN, ; Staal, A. H. J.; Schoffelen, T.; Gorris, M. A. J.; Van der Woude, L. L.; Jansen, A. F. M.; Poyck, P.; Van Suylen, R. J.; Wever, P. C.; Bleeker-Rovers, C. P.; Srinivas, M.; Hebeda, K. M.; van Deuren, M.; Van der Meer, J. W.; De Vries, J. M.; Van Kimmenade, R. R. J.
10.1101/2021.08.27.457923 — immunology — Posted on 2021-08-28
451 Gene signature of circulating platelet-bound neutrophils is associated with poor prognosis in cancer patients
Lecot, P.; Ardin, M.; Dussurgey, S.; Alcazer, V.; Moudombi, L.; Hubert, M.; Swalduz, A.; Hernandez-Vargas, H.; Viari, A.; Caux, C.; Michallet, M.-C.
10.1101/2021.08.26.457803 — immunology — Posted on 2021-08-28
453 Extensive incorporation, polarisation and improved maturation of transplanted human cones in a murine cone degeneration model
Gasparini, S. J.; Tessmer, K.; Reh, M.; Wieneke, S.; Carido, M.; Voelkner, M.; Borsch, O.; Swiersy, A.; Zusic, M.; Goureau, O.; Kurth, T.; Busskamp, V.; Zeck, G.; Karl, M. O.; Ader, M.
10.1101/2021.08.26.457641 — neuroscience — Posted on 2021-08-28
454 Recurrent de novo single point mutation on the gene encoding Na+ /K+ pump results in epilepsy
Liu, Z.-Z.; xie, h.; Li, H.-M.; Hu, W.-B.; Hong, C.-G.; Duan, R.; Chen, M.-L.; Cao, J.; Wang, Z.-X.; Chen, C.-Y.; Zhong, L.-H.; Yin, F.; Hu, Z.-H.; Li, J.
10.1101/2021.08.26.457802 — neuroscience — Posted on 2021-08-28
456 Multiplexed and reproducible high content screening of live and fixed cells using the Dye Drop method
Mills, C. E.; Subramanian, K.; Hafner, M.; Niepel, M.; Gerosa, L.; Chung, M.; Victor, C.; Gaudio, B.; Yapp, C.; Sorger, P. K.
10.1101/2021.08.27.457854 — systems biology — Posted on 2021-08-28
458 A promiscuity locus confers Lotus burttii nodulation with rhizobia from five different genera
Zarrabian, M.; Montiel, J.; Sandal, N.; Jin, H.; Lin, Y.-Y.; Klingl, V.; Marin, M.; James, E. K.; Parniske, M.; Stougaard, J.; Andersen, S. U.
10.1101/2021.08.26.457880 — plant biology — Posted on 2021-08-28
461 An integrated model for termination of RNA polymerase III transcription
Xie, J.; Aiello, U.; Clement, Y.; Haidara, N.; Girbig, M.; Schmitzova, J.; Pena, V.; Muller, C. W.; Libri, D.; Porrua, O.
10.1101/2021.08.27.457903 — genomics — Posted on 2021-08-28
463 Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease
Sanchez-Ceinos, J.; Guzman-Ruiz, R.; Rangel-Zuniga, O. A.; Lopez-Alcala, J.; Moreno-Cano, E.; del Rio-Moreno, M.; Romero-Cabrera, J. L.; Perez-Martinez, P.; Maymo-Masip, E.; Vendrell, J.; Fernandez-Veledo, S.; Fernandez-Real, J. M.; Laurencikiene, J.; Ryden, M.; Membrives, A.; Luque, R. M.; Lopez-Miranda, J.; M. Malagon, M.
10.1101/2021.01.15.426823 — cell biology — Posted on 2021-08-28
465 Using Continuous Directed Evolution to Improve Enzymes for Plant Applications
Garcia-Garcia, J. D.; Van Gelder, K.; Joshi, J.; Bathe, U.; Leong, B. J.; Bruner, S. D.; Liu, C. C.; Hanson, A. D.
10.1101/2021.08.26.457776 — synthetic biology — Posted on 2021-08-28
466 Microenvironmental correlates of immune checkpoint inhibitor response in human melanoma brain metastases revealed by T cell receptor and single-cell RNA sequencing
Alvarez-Breckenridge, C. A.; Markson, S. C.; Stocking, J. H.; Nayyar, N.; Lastrapes, M.; Strickland, M. R.; Kim, A. E.; de Sauvage, M.; Dahal, A.; Larson, J. M.; Mora, J. L.; Navia, A. W.; Kuter, B. M.; Gill, C. M.; Bertalan, M. S.; Shaw, B.; Kaplan, A.; Subramanian, M.; Jain, A.; Danish, H.; Kumar, S.; White, M.; Shahid, O.; Pauken, K. E.; Miller, B. C.; Izar, B.; Davies, M.; Frederick, D. T.; Boland, G. M.; Herbert, C.; Shaw, M.; Martinez-Lage, M.; Frosch, M. P.; Wang, N.; Gerstner, E. R.; Nahed, B. V.; Curry, W. T.; Carter, B. S.; Cahill, D. P.; Sharpe, A.; Suv?, M. L.; Sullivan, R. J.; Bra
10.1101/2021.08.25.456956 — cancer biology — Posted on 2021-08-28
467 A functional network target for tic reduction during thalamic stimulation for Tourette Syndrome
Baldermann, J. C.; Hennen, C.; Schueller, T.; Andrade, P.; Visser-Vandewalle, V.; Horn, A.; Dembek, T. A.; Petry-Schmelzer, J. N. A.; Strelow, J.; Jergas, H.; Kuhn, J.; Barbe, M.; Huys, D.
10.1101/2021.08.27.457924 — neuroscience — Posted on 2021-08-28
471 Wear and Tear of the Intestinal Visceral Musculature by Intrinsic and Extrinsic Factors
Kim, H. D.; So, E.; Lee, J.; Wang, Y.; Gill, V. S.; Gorbacheva, A.; Han, H. J.; Ng, K. G.- L.; Ning, K.; Pranoto, I. K. A.; Cabrera, A. J. H.; Eom, D. S.; Kwon, Y. V.
10.1101/2021.08.26.457849 — developmental biology — Posted on 2021-08-27
472 NKG2D signaling regulates IL-17A-producing γδT cells to promote cancer progression
Curio, S.; Edwards, S. C.; Suzuki, T.; McGovern, J.; Triulzi, C.; Yoshida, N.; Jonsson, G.; Glauner, T.; Rami, D.; Purcell, R.; Coffelt, S. B.; Guerra, N.
10.1101/2021.08.26.457761 — immunology — Posted on 2021-08-27
476 Health assessment of the pink land iguana, Conolophus marthae.
Gentile, G.; Colosimo, G.; Vera, C. A.; Gerber, G. P.; Westermeyer, H.; Sevilla, C.; Lewbart, G. A.
10.1101/2021.08.26.457766 — zoology — Posted on 2021-08-27
477 Standardized genome-wide function prediction enables comparative functional genomics: a new application area for Gene Ontologies in plants
Fattel, L.; Psaroudakis, D.; Yanarella, C.; Chiteri, K.; Dostalik, H. A.; Joshi, P.; Starr, D. C.; Vu, H.; Wimalanathan, K.; Lawrence-Dill, C. J.
10.1101/2021.04.25.441366 — bioinformatics — Posted on 2021-08-27
478 Successive remodeling of IgG glycans using a solid-phase enzymatic platform
Mann, B. F.; Hsu, Y.-P.; Verma, D.; Sun, S.; McGregor, C.; Mangion, I.
10.1101/2021.08.27.457991 — biochemistry — Posted on 2021-08-27
479 mobileOG-db: a manually curated database of protein families mediating the life cycle of bacterial mobile genetic elements
Brown, C. L.; Mullet, J.; Hindi, F.; Stoll, J.; Gupta, S.; Choi, M.; Keenum, I.; Vikesland, P.; Pruden, A.; ZHANG, L.
10.1101/2021.08.27.457951 — genomics — Posted on 2021-08-27
481 Genome-wide local ancestry and direct evidence for mitonuclear co-adaptation in African hybrid cattle populations (Bos taurus/indicus)
Ward, J. A.; McHugo, G. P.; Dover, M. J.; Hall, T. J.; Ng'ang'a, S. I.; Sonstegard, T. S.; Bradley, D. G.; Frantz, L. A.; Salter-Townshend, M.; MacHugh, D. E.
10.1101/2021.08.26.457829 — evolutionary biology — Posted on 2021-08-27
485 Rapid depletion of CTCF and cohesin proteins reveals dynamic features of chromosome architecture.
Liu, N. Q.; Magnitov, M.; Schijns, M. M. G. A.; van Schaik, T.; van der Weide, R. H.; Teunissen, H.; van Steensel, B.; de Wit, E.
10.1101/2021.08.27.457977 — molecular biology — Posted on 2021-08-27
487 An improved iCLIP protocol
Lee, F. C. Y.; Chakrabarti, A. M.; Hänel, H.; Monzon-Casanova, E.; Hallegger, M.; Militti, C.; Capraro, F.; Sadee, C.; Toolan-Kerr, P.; Wilkins, O.; Turner, M.; König, J.; Sibley, C.; Ule, J.
10.1101/2021.08.27.457890 — molecular biology — Posted on 2021-08-27
492 KLF4 induces Mesenchymal-Epithelial Transition (MET) by suppressing multiple EMT-inducing transcription factors
Subbalakshmi, A. R.; Sahoo, S.; McMullen, I.; Saxena, A. N.; Venugopal, S. K.; Somarelli, J.; Jolly, M. K.
10.1101/2021.08.26.457621 — cancer biology — Posted on 2021-08-27
493 Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoids.
Le Blanc, S.; Ishaque, N.; Jabs, J.; Bauer, T.; Schuth, S.; Hu, Q.; Debnath, O.; Ten, F. W.; Leonhardt, C.-S.; König, A.-K.; Bieg, M.; Eckert, C.; Gaida, M. M.; Volkmar, M.; Hübschmann, D.; Schenk, M.; Offringa, R.; Giese, N. A.; Schlesner, M.; Büchler, M. W.; Eils, R.; Conrad, C.; Strobel, O.
10.1101/2021.08.26.457743 — cancer biology — Posted on 2021-08-27
494 A non-canonical convergence of carbohydrate and glutamine metabolism is required after metabolic rewiring in 3D environment
Wei, P.; Bott, A. J.; Cluntun, A. A.; Morgan, J. T.; Cunningham, C. N.; Schell, J. C.; Ouyang, Y.; Ficarro, S. B.; Marto, J. A.; Danial, N. N.; DeBerardinis, R. J.; Rutter, J.
10.1101/2021.08.26.457847 — cancer biology — Posted on 2021-08-27
497 Comparison of linear combination modeling strategies for GABA-edited MRS at 3T
Zöllner, H. J.; Tapper, S.; Hui, S. C. N.; Barker, P. B.; Edden, R. A. E.; Oeltzschner, G.
10.1101/2021.05.26.445817 — biochemistry — Posted on 2021-08-27
499 Oral Glucosamine Ameliorates Aggravated Neurological Phenotype in Mucopolysaccharidosis III Type C Mouse Model Expressing Misfolded HGSNAT Variant
Pan, X.; Taherzadeh, M.; Bose, P.; Heon-Roberts, R.; Nguyen, A. L. A.; Xu, T.; Para, C.; Yamanaka, Y.; Priestman, D. A.; Platt, F. M.; Khan, S.; Fnu, N.; Tomatsu, S.; Morales, C. R.; Pshezhetsky, A. V.
10.1101/2021.08.26.457793 — animal behavior and cognition — Posted on 2021-08-27
500 Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders
Pagliaroli, L.; Porazzi, P.; Curtis, A.; Scopa, C.; Mikkers, H.; Freund, C.; Daxinger, L.; Deliard, S.; Offley, S.; Welsh, S.; Ott, C.; Calabretta, B.; Brugmann, S. A.; Santen, G.; Trizzino, M.
10.1101/2021.04.02.438227 — genomics — Posted on 2021-08-27
502 Kif9 is an active kinesin motor required for ciliary beating and proximodistal patterning of motile axonemes
konjikusic, M.; wallingford, j.; gray, r.; verhey, k.; yang, y.; prakash, v.; horani, a.; brody, s.; nguimtsop, m.; lee, c.; Shrestha, B.
10.1101/2021.08.26.457815 — cell biology — Posted on 2021-08-27
503 Characterization of USH1C/harmonin in the human retina provides insights into pathophysiology and therapy options for Usher syndrome
Nagel-Wolfrum, K.; Fadl, B. R.; Becker, M. M.; Wunderlich, K. A.; Schaefer, J.; Sturm, D.; Guer, B.; Kaplan, L.; Goldmann, T.; Brooks, M.; Starostik, M. R.; Apel, M.; Fath, K. R.; Stingl, K.; Kohl, S.; Andrade, M.; Vetter, J. M.; Pfeiffer, N.; Grosche, A. A.; Swaroop, A.; Wolfrum, U.
10.1101/2021.08.27.457962 — molecular biology — Posted on 2021-08-27
506 Air-nanobubbles ineffective to reduce pathogenic bacteria in fresh and brackish waters
Domingos, J. A.; Huang, Q.; Liu, H.; Dong, H. T.; Khongcharoen, N.; Van, P. T.; Nghia, N. H.; Giang, P. T.; The Viet, P.; St-Hilaire, S.
10.1101/2021.08.27.457885 — microbiology — Posted on 2021-08-27
507 A highly active phosphate-insensitive phosphatase is widely distributed in nature
Lidbury, I. D. E. A.; Scanlan, D.; Murphy, A. R. J.; Christie-Oleza, J.; Aguilo-Ferretjans, M. d. M.; Hitchcock, A.; Daniell, T.
10.1101/2021.08.27.457942 — microbiology — Posted on 2021-08-27
509 Cryo-ET of a human GBP coatomer governing cell-autonomous innate immunity to infection
MacMicking, J. D.; Zhu, S.; Bradfield, C. J.; Maminska, A.; Park, E.; Kim, B.; Kumar, P.; Huang, S.; Zhang, Y.; Bewersdorf, J.
10.1101/2021.08.26.457804 — immunology — Posted on 2021-08-27
515 Oxo-M and 4-PPBP Delivery via Multi-Domain Peptide Hydrogel Toward Tendon Regeneration
Park, G. Y.; Tarafder, S.; Eyen, S. L.; Park, S.; Kim, R.; Siddiqui, Z.; Kumar, V.; Lee, C. H.
10.1101/2021.08.25.457430 — bioengineering — Posted on 2021-08-27
516 Leveraging Fungal Calcineurin-Inhibitor Structures, Biophysics and Dynamics to Design Selective and Non-Immunosuppressive FK506 Analogs
Gobeil, S. M.- C.; Bobay, B. G.; Juvvadi, P. R.; Cole, C. D.; Heitman, J.; Steinbach, W. J.; Venters, R. A.; Spicer, L. D.
10.1101/2020.04.14.039800 — biochemistry — Posted on 2021-08-27
517 Ankylosis homologue mediates cellular efflux of ATP, not pyrophosphate
Szeri, F.; Niaziorimi, F.; Donnelly, S.; Fariha, N.; Tertyshnaia, M.; Patel, D.; Lundkvist, S.; van de Wetering, K.
10.1101/2021.08.27.457978 — biochemistry — Posted on 2021-08-27
521 Signaling and transcriptional networks governing late synovial joint development
Bian, Q.; Cheng, Y.-H.; Su, E. Y.; Tan, Y.; Kim, D. W.; Wang, H.; Yoo, S.; Blackshaw, S.; Cahan, P.
10.1101/2021.08.25.457383 — developmental biology — Posted on 2021-08-27
522 Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures
Rausser, S.; Trumpff, C.; McGill, M. A.; Junker, A.; Wang, W.; Ho, S.-H.; Mitchell, A.; Karan, K. R.; Monk, C.; Segerstrom, S. C.; Reed, R. G.; Picard, M.
10.1101/2020.10.16.342923 — cell biology — Posted on 2021-08-27
523 The indoleamine 2,3 dioxygenase pathway drives intratumoral B cell maintenance.
Johnson, B. A.; Aragaki, A. K.; Williams, D. M.; Rogers, O.; Mountain, J.; Luo, L.; Zhang, W.; Xian, L.; Feng, M.; Chia, L.; Dordai, D.; Hahn, N. M.; Desiderio, S.; Johnson, T. S.; McConkey, D. J.; Resar, L. M. S.
10.1101/2021.08.25.456776 — immunology — Posted on 2021-08-27
525 Amphetamine alters the Reward Positivity in humans and mice
Cavanagh, J. F.; Olguin, S.; Talledo, J.; Kotz, J.; Roberts, B.; Nungary, J. A.; Sprock, J.; Gregg, D.; Bhakta, S. G.; Light, G. A.; Swerdlow, N. R.; Young, J. W.; Brigman, J. L.
10.1101/2021.08.25.457689 — neuroscience — Posted on 2021-08-27
530 Using Conspecific Playbacks to Investigate Contact Calling in Southeast Alaskan Humpback Whales
Fournet, M. E.; Matthews, L. P.; Bartlett, A.; Mastick Jensen, N.; Doyle, L.; Sharpe, F.; Crutchfield, J. P.; McCowan, B.; Mellinger, D. K.
10.1101/2021.08.25.457675 — animal behavior and cognition — Posted on 2021-08-27
531 Locus-specific chromatin profiling of evolutionarily young transposable elements
Taylor, D.; Lowe, R. R.; Philippe, C.; Cheng, K. C. L.; Cristofari, G.; Branco, M. R.
10.1101/2021.08.25.457666 — genomics — Posted on 2021-08-27
536 Optical mini-stroke of thalamic networks impairs sleep stability, topography and cognition.
Lenzi, I.; Borsa, M.; Czekus, C.; Rusterholz, T.; Bassetti, C. L.; Gutierrez Herrera, C. G.
10.1101/2021.08.25.457501 — neuroscience — Posted on 2021-08-27
537 Anterior thalamic nuclei neurons sustain memory
Barnett, S. C.; Parr-Brownlie, L. C.; Perry, B. A. L.; Young, C. K.; Wicky, H. H.; Hughes, S. M.; McNaughton, N.; Dalrymple-Alford, J. C.
10.1101/2021.08.25.457615 — neuroscience — Posted on 2021-08-27
539 CALANGO: an annotation-based, phylogeny-aware comparative genomics framework for exploring and interpreting complex genotypes and phenotypes
Hongo, J. A.; de Castro, G. M.; Rios Picorelli, A. C.; Martins da Silva, T. T.; Imada, E. L.; Marchionni, L.; Chaves, A. V.; Almeida, G.; Campelo, F.; Pereira Lobo, F.
10.1101/2021.08.25.457574 — bioinformatics — Posted on 2021-08-27
540 M-CAMP™: A cloud-based web platform with a novel approach for species-level classification of 16S rRNA microbiome sequences
Schriefer, A. E.; Kumar, B.; Zolty, A.; R, P.; Didier, A.; MG, N.; Nadiv, N.; Perez, M.; Mahankuda, S. K.; Kumar, P.; GT, G.; Tenney, A.; Bourner, M.; Lezer, S.; Zhong, F.; Daniely, M.; Liu, Y.
10.1101/2021.08.25.456838 — bioinformatics — Posted on 2021-08-27
541 Cerebrovascular super-resolution 4D Flow MRI - using deep learning to non-invasively quantify velocity, flow, and relative pressure
Ferdian, E.; Marlevi, D.; Schollenberger, J.; Aristova, M.; Edelman, E. R.; Schnell, S.; Figueroa, C. A.; Nordsletten, D. A.; Young, A. A.
10.1101/2021.08.25.457611 — bioengineering — Posted on 2021-08-27
542 Adduction Induces Large Optic Nerve Head Deformations in Subjects with Normal Tension Glaucoma
Chuangsuwanich, T.; Tun, T. A.; Wang, X.; Chin, Z. Y.; Panda, S. K.; Buist, M.; Milea, D.; Strouthidis, N.; Perera, S.; Nongpiur, M. E.; Tin, A.; Girard, M. J. A.
10.1101/2021.08.25.457300 — bioengineering — Posted on 2021-08-27
543 The genome trilogy of Anopheles stephensi, an urban malaria vector, reveals structure of a locus associated with adaptation to environmental heterogeneity
Thakare, A.; Ghosh, C.; Alalamath, T.; Kumar, N.; Narang, H.; Whadgar, S.; Paul, K.; Shrotri, S.; Kumar, S.; M, S.; Rao, R.; Chakraborty, M.; Choudhary, B.; Ghosh, S. K.; Subramani, S. K.; Swain, S.; Srinivasan, S.
10.1101/2021.08.25.457468 — genomics — Posted on 2021-08-27
545 Assessing the impacts of climate change on reproductive phenology in tropical rainforests of Southeast Asia
Numata, S.; Yamaguchi, K.; Shimizu, M.; Sakurai, G.; Morimoto, A.; Alias, N.; Azman, N. Z. N.; Hosaka, T.; Satake, A.
10.1101/2021.08.24.457576 — ecology — Posted on 2021-08-27
546 The Enemy of my Enemy is my Friend: Immune-Mediated Facilitation Contributes to Fitness of Co-Infecting Helminths
Dagostin, F.; Vanalli, C. M.; Boag, B.; Casagrandi, R.; Gatto, M.; Mari, L.; Cattadori, I. M.
10.1101/2021.08.25.457665 — ecology — Posted on 2021-08-27
547 Sea lice (Lepeophtherius salmonis) detection and quantification around aquaculture installations using environmental DNA
Krolicka, A.; Maland Nilsen, M.; Provan, F.; Klitgaard Hansen, B.; Wulf Jacobsen, M.; Baussant, T.
10.1101/2021.08.25.457635 — ecology — Posted on 2021-08-27
549 Rapid 3D-STORM imaging of diverse molecular targets in tissue
Albrecht, N. E.; Jiang, D.; Hobson, R.; Speer, C.; Samuel, M. A.
10.1101/2021.08.25.457670 — neuroscience — Posted on 2021-08-27
552 Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes
Ignatenko, O.; Malinen, S.; Vihinen, H.; Nikkanen, J.; Kononov, A.; Jokitalo, E.; Ince-Dunn, G.; Suomalainen, A.
10.1101/2021.08.24.457472 — neuroscience — Posted on 2021-08-27
555 A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseases
Li, Z.; Wu, J.; Zhou, J.; Yuan, B.; Chen, J.; Wu, W.; Mo, L.; Qu, Z.; Zhou, F.; Dong, Y.; Huang, K.; Liu, Z.; Wang, T.; Symmes, D.; Gu, J.; Sho, E.; Zhang, J. p.; Chen, R.; Xu, Y.
10.1101/2021.08.26.457884 — pharmacology and toxicology — Posted on 2021-08-27
561 From Alpha to Zeta: Identifying variants and subtypes of SARS-CoV-2 via clustering
Melnyk, A.; Mohebbi, F.; Knyazev, S.; Sahoo, B.; Hosseini, R.; Skums, P.; Zelikovskiy, A.; Patterson, M. D.
10.1101/2021.08.26.457874 — bioinformatics — Posted on 2021-08-27
563 Long-term precision editing of neural circuits using engineered gap junction hemichannels
Ransey, E.; Chesnov, K.; Wisdom, E.; Bowman, R.; Rodriguez, T.; Adamson, E.; Thomas, G.; Almoril-Porras, A.; Schwennesen, H.; Colon-Ramos, D.; Hultman, R.; Bursac, N.; Dzirasa, K.
10.1101/2021.08.24.457429 — neuroscience — Posted on 2021-08-27
565 Theoretical causes of the Brazilian P.1 and P.2 lineages of the SARS-CoV-2 virus through molecular dynamics
Lima de Oliveira, M. D.; Teixeira de Oliveira, K. M.; Nunes da Silva, J.; Santos, C.; Bessa, J.; de Freitas, R.
10.1101/2021.04.09.439181 — biophysics — Posted on 2021-08-27
567 Adaptation in outbred sexual yeast is repeatable, polygenic, and favors rare haplotypes
Linder, R.; Zabanavar, B.; Majumder, A.; Chiao-Shyan, H.; Delgado, V. G.; Tran, R.; La, V. T.; Long, A.
10.1101/2021.08.27.457900 — evolutionary biology — Posted on 2021-08-27
573 Conserved genomic landscapes of differentiation across Populus speciation continuum
Shang, H.; Rendon-Anaya, M.; Paun, O.; Field, D. L.; Hess, J.; Vogl, C.; Liu, J.; Ingvarsson, P. K.; Lexer, C.; Leroy, T.
10.1101/2021.08.26.457771 — evolutionary biology — Posted on 2021-08-27
574 Robust, Universal Tree Balance Indices
Lemant, J.; Le Sueur, C.; Manojlovic, V.; Noble, R. J.
10.1101/2021.08.25.457695 — evolutionary biology — Posted on 2021-08-27
578 MSA Transformer
Rao, R. M.; Liu, J.; Verkuil, R.; Meier, J.; Canny, J.; Abbeel, P.; Sercu, T.; Rives, A.
10.1101/2021.02.12.430858 — synthetic biology — Posted on 2021-08-27
579 Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.
Velez-Delgado, A.; Donahue, K. L.; Brown, K. L.; Du, W.; Irizarry-Negron, V.; Menjivar, R. E.; Lasse-Opsahl, E. L.; Steele, N. G.; The, S.; Lazarus, J.; Sirihorachai, V. R.; Yan, W.; Kemp, S. B.; Kerk, S. A.; Bollamplly, M.; Lima, F.; Lyssiotis, C. A.; Rao, A.; Crawford, H. C.; Bednar, F.; Frankel, T. L.; Zhang, Y.; Pasca di Magliano, M.
10.1101/2021.08.26.457660 — cancer biology — Posted on 2021-08-27
582 Harbor porpoise losing its edges: genetic time series suggests a rapid population decline in Iberian waters over the last 30 years
Ben Chehida, Y.; Stelwagen, T.; Hoekendijk, J. P. A.; Ferreira, M.; Eira, C.; Pereira, A. T.; Nicolau, L.; Marcalo, A.; Thumloup, J.; Fontaine, M. C.
10.1101/2021.08.19.456945 — evolutionary biology — Posted on 2021-08-27
586 Extracellular matrix stiffness regulates degradation of the Hippo kinase MST2 via SCFβTrCP
Fiore, A. P. Z. P.; da Silva, A. M. R.; Ribeiro, H. V.; Manucci, A. C.; Ribeiro, P. d. F.; Silva Botelho, M. C.; Oliveira, P. S. L.; Pagano, M.; Bruni-Cardoso, A.
10.1101/2021.01.31.429078 — cell biology — Posted on 2021-08-27
587 Transient DUX4 expression induces blastomere-like expression program that is marked by SLC34A2
Yoshihara, M.; Kirjanov, I.; Nykänen, S.; Sokka, J.; Weltner, J.; Lundin, K.; Gawriyski, L.; Jouhilahti, E.-M.; Varjosalo, M.; Tervaniemi, M. H.; Otonkoski, T.; Trokovic, R.; Katayama, S.; Vuoristo, S.; Kere, J.
10.1101/2021.08.25.457357 — cell biology — Posted on 2021-08-27
590 Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress
Morgan, K. J.; Doggett, K.; Geng, F.-S.; Whitehead, L.; Smith, K. A.; Hogan, B. M.; Simons, C.; Baillie, G. J.; Molania, R.; Papenfuss, A. T.; Hall, T. E.; Ober, E. A.; Stainier, D. Y. R.; Gong, Z.; Heath, J. K.
10.1101/2021.08.25.457580 — cancer biology — Posted on 2021-08-27
592 Single-cell chromatin and transcriptome dynamics of Synovial Fibroblasts transitioning from homeostasis to pathology in modelled TNF-driven arthritis
Armaka, M.; Konstantopoulos, D.; Tzaferis, C.; Lavigne, M. D.; Sakkou, M.; Liakos, A.; Sfikakis, P. P.; Dimopoulos, M. A.; Fousteri, M.; Kollias, G.
10.1101/2021.08.27.457747 — cell biology — Posted on 2021-08-27
595 Computational Studies of Substrate Transport and Specificity in a Phospholipid Flippase
Wang, Y.; Lyons, J. A.; Timcenko, M.; Kümmerer, F.; de Groot, B. L.; Nissen, P.; Gapsys, V.; Lindorff-Larsen, K.
10.1101/2020.06.24.169771 — biophysics — Posted on 2021-08-27
597 Differential responses of amphibians and reptiles to land-use change in the biodiversity hotspot of north-eastern Madagascar
Fulgence, T. R.; Martin, D. A.; Randriamanantena, R.; Botra, R.; Befidimanana, E.; Osen, K.; Wurz, A.; Kreft, H.; Andrianarimisa, A.; Ratsoavina, F. M.
10.1101/2021.03.18.435920 — ecology — Posted on 2021-08-27
599 Enhanced negative response to stress following morphine administration increases wanting of social reward
Massaccesi, C.; Willeit, M.; Quednow, B. B.; Nater, U. M.; Lamm, C.; Mueller, D.; Silani, G.
10.1101/2021.08.13.456110 — neuroscience — Posted on 2021-08-27
602 Adar-mediated A-to-I editing is required for establishment of embryonic body axes in zebrafish
Niescierowicz, K.; Pryszcz, L.; Navarrete, C.; Tralle, E.; Kasprzyk, M. E.; Abu Nahia, K.; Misztal, K.; Bochtler, M.; Winata, C.
10.1101/2021.08.26.457081 — developmental biology — Posted on 2021-08-26
603 Post-stroke dendritic arbor regrowth - a cortical repair process requiring the actin nucleator Cobl
Ji, Y.; Koch, D.; Delgado, J. G.; Günther, M.; Witte, O. W.; Kessels, M. M.; Frahm, C.; Qualmann, B.
10.1101/2021.08.26.457764 — neuroscience — Posted on 2021-08-26
607 Health assessment of the pink land iguana, Conolophus marthae.
Lewbart, G. A.; Gentile, G.; Colosimo, G.; Gerber, G.; Vera, C.
10.1101/2021.08.26.457766 — zoology — Posted on 2021-08-26
608 A quantitative mapping approach to identify direct interactions within complexomes
Trepte, P.; Secker, C.; Choi, S. G.; Olivet, J.; Ramos, E. S.; Cassonnet, P.; Golusik, S.; Zenkner, M.; Beetz, S.; Sperling, M.; Wang, Y.; Hao, T.; Spirohn, K.; Twizere, J.-C.; Calderwood, M. A.; Hill, D. E.; Jacob, Y.; Vidal, M.; Wanker, E. E.
10.1101/2021.08.25.457734 — systems biology — Posted on 2021-08-26
610 High performance single-cell gene regulatory network inference atscale: The Inferelator 3.0
Skok Gibbs, C.; Jackson, C. A.; Saldi, G.-A.; Tjärnberg, A.; Shah, A.; Watters, A.; De Veaux, N.; Tchourine, K.; Yi, R.; Hamamsy, T.; Castro, D. M.; Carriero, N.; Gresham, D.; Miraldi, E. R.; Bonneau, R.
10.1101/2021.05.03.442499 — systems biology — Posted on 2021-08-26
612 Genomic drivers of large B-cell lymphoma resistance to CD19 CAR-T therapy
Jain, M. D.; Ziccheddu, B.; Coughlin, C. A.; Faramand, R.; Griswold, A. J.; Reid, K. M.; Landgren, O.; Locke, F. L.; Maura, F.; Davila, M. L.; Schatz, J. H.
10.1101/2021.08.25.457649 — cancer biology — Posted on 2021-08-26
613 Designing and interpreting 4D tumour spheroid experiments
Murphy, R. J.; Browning, A. P.; Gunasingh, G.; Haass, N. K.; Simpson, M. J.
10.1101/2021.08.18.456910 — biophysics — Posted on 2021-08-26
616 Developmental Venous Anomalies are a Genetic Primer for Cerebral Cavernous Malformations
Snellings, D. A.; Girard, R.; Lightle, R.; Srinath, A.; Romanos, S.; Li, Y.; Chen, C.; Ren, A. A.; Kahn, M. L.; Awad, I. A.; Marchuk, D. A.
10.1101/2021.08.25.457657 — genetics — Posted on 2021-08-26
621 Stop codon recoding is widespread in diverse phage lineages and has the potential to regulate translation of late stage and lytic genes
Borges, A. L.; Lou, Y. C.; Sachdeva, R.; Al-Shayeb, B.; Jaffe, A. L.; Lei, S.; Santini, J. M.; Banfield, J. F.
10.1101/2021.08.26.457843 — microbiology — Posted on 2021-08-26
623 Towards the Interpretability of Deep Learning Models for Human Neuroimaging
Hofmann, S. M.; Beyer, F.; Lapuschkin, S.; Markus, L.; Mueller, K.-R.; Villringer, A.; Samek, W.; Witte, A. V.
10.1101/2021.06.25.449906 — neuroscience — Posted on 2021-08-26
626 L-citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia
Man, A. W. C.; Zhou, Y.; Lam, U. D.; Reifenberg, G.; Werner, A.; Habermeier, A.; Closs, E.; Daiber, A.; Münzel, T.; Ning, X.; Li, H.
10.1101/2021.08.24.457514 — pharmacology and toxicology — Posted on 2021-08-26
627 Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
Clemens, M. M.; Kennon-McGill, S.; Vazquez, J. H.; Stephens, O. W.; Peterson, E. A.; Johann, D. J.; Allard, F. D.; Yee, E. U.; McCullough, S. S.; James, L. P.; Finck, B. N.; McGill, M. R.
10.1101/2020.12.22.423312 — pharmacology and toxicology — Posted on 2021-08-26
629 Bridge Category Models: Development of Bayesian Modelling Procedures to Account for Bridge Ordinal Ratings for Disease Staging
Levy, J.; Bobak, C. A.; Azizgolshani, N.; Andersen, M. J.; Suriawinata, A.; Liu, X.; Lisovsky, M.; Ren, B.; Christensen, B.; Vaickus, L.; O'Malley, J.
10.1101/2021.08.17.456726 — pathology — Posted on 2021-08-26
631 Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors
Foster, J. B.; Griffin, C.; Rokita, J. L.; Stern, A.; Brimley, C.; Rathi, K.; Lane, M. V.; Buongervino, S. N.; Smith, T.; Madsen, P. J.; Martinez, D.; Wechsler-Reya, R.; Kariko, K.; Storm, P. B.; Barrett, D. M.; Resnick, A. C.; Maris, J. M.; Bosse, K. R.
10.1101/2021.07.06.451385 — cancer biology — Posted on 2021-08-26
635 homeRNA: A self-sampling kit for the collection of peripheral blood and stabilization of RNA
Haack, A. J.; Lim, F. Y.; Kennedy, D. S.; Day, J. H.; Adams, K. N.; Lee, J. J.; Berthier, E.; Theberge, A. B.
10.1101/2021.02.08.430337 — bioengineering — Posted on 2021-08-26
638 Evolutionarily conserved genetic interactions between nphp-4 and bbs-5 mutations exacerbate ciliopathy phenotypes
Bentley-Ford, M. R.; LaBonty, M.; Thomas, H. R.; Haycraft, C. J.; Scott, M.; LaFayette, C.; Croyle, M. J.; Parant, J. M.; Yoder, B. K.
10.1101/2021.08.25.457729 — genetics — Posted on 2021-08-26
639 Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes
Hindy, G.; Dornbos, P.; Chaffin, M. D.; Liu, D. J.; Wang, M. X.; Aguilar-Salinas, C. A.; Antonacci-Fulton, L.; Ardissino, D.; Arnett, D. K.; Aslibekyan, S.; Atzmon, G.; Ballantyne, C. M.; Barajas-Olmos, F.; Barzilai, N.; Becker, L. C.; Bielak, L. F.; Bis, J. C.; Blangero, J.; Boerwinkle, E.; Bonnycastle, L. L.; Bottinger, E.; Bowden, D. W.; Bown, M. J.; Brody, J. A.; Broome, J. G.; Burtt, N. P.; Cade, B. E.; Centeno-Cruz, F.; Chan, E.; Chang, Y.-C.; Chen, Y.-D. I.; Cheng, C.-Y.; Choi, W. J.; Chowdhury, R.; Contreras-Cubas, C.; Cordova, E. J.; Correa, A.; Cupples, L. A.; Curran, J. E.; Danesh,
10.1101/2020.12.22.423783 — genetics — Posted on 2021-08-26
640 Genetic coupling of life-history and aerobic performance in juvenile Atlantic salmon
Prokkola, J. M.; Asheim, E. R.; Morozov, S.; Bangura, P.; Erkinaro, J.; Ruokolainen, A.; Primmer, C. R.; Aykanat, T.
10.1101/2021.08.23.457324 — evolutionary biology — Posted on 2021-08-26
643 PP2A-Cdc55 phosphatase coordinates actomyosin ring contraction and septum formation during cytokinesis
Moyano-Rodriguez, Y.; Vaquero, D.; Vilalta-Castany, O.; Foltman, M.; Sanchez-Diaz, A.; Queralt, E.
10.1101/2020.11.27.400903 — cell biology — Posted on 2021-08-26
645 Leaked genomic and mitochondrial DNA contribute to the host response to noroviruses in a STING-dependent manner
Jahun, A. S.; Sorgeloos, F.; Chaudhry, Y.; Arthur, S. E.; Hosmillo, M.; Georgana, I.; Izuagbe, R.; Goodfellow, I. G.
10.1101/2021.08.26.457800 — molecular biology — Posted on 2021-08-26
646 Detection of Multiple Types of Cancer Driver Mutations Us-ing Targeted RNA Sequencing in NSCLC
Ju, S.; Cui, Z.; hong, y.; Wang, x.; mu, w.; Xie, Z.; zeng, x.; su, l.; zhang, q.; song, x.; you, .s.; chen, r.; chen, w.; chun, x.; Zhao, J.
10.1101/2021.08.25.457723 — molecular biology — Posted on 2021-08-26
651 Relationship between bacterial phylotype and specialized metabolite production in the culturable microbiome of two freshwater sponges
Clark, C. M.; Hernandez, A.; Mullowney, M. W.; Fitz-Henley, J.; Li, E.; Romanowski, S. B.; Pronzato, R.; Manconi, R.; Murphy, B. T.
10.1101/2021.08.26.457769 — microbiology — Posted on 2021-08-26
652 Subsurface Hydrocarbon Degradation Strategies in Low- and High-Sulfate Coal Seam Communities Identified with Activity-Based Metagenomics
Schweitzer, H. D.; Smith, H. J.; Barnhart, E. P.; McKay, L. J.; Gerlach, R.; Cunningham, A. B.; Malmstrom, R.; Goudeau, D.; Fields, M. W.
10.1101/2021.08.26.457739 — microbiology — Posted on 2021-08-26
656 A hierarchical GBP network promotes cytosolic LPS recognition and sepsis
MacMicking, J. D.; Park, E.; Kim, B.; Kumar, P.; Tretina, K.; Maminska, A.; Philbrick, W. M.; Flavell, R.
10.1101/2021.08.25.457662 — immunology — Posted on 2021-08-26
657 Distributed coding of stimulus magnitude in rodent prefrontal cortex
Henke, J.; Bunk, D.; von Werder, D.; Haeusler, S.; Flanagin, V. L.; Thurley, K.
10.1101/2020.04.02.021287 — neuroscience — Posted on 2021-08-26
662 Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma
Boyd, R. J.; Olson, T.; Zook, J.; Aceves, M.; Stein, D.; Lin, W.-H.; Craciunescu, F.; Hansen, D. T.; Anastasiadis, P. Z.; Singharoy, A.; Fromme, P.
10.1101/2021.08.26.457821 — biochemistry — Posted on 2021-08-26
668 Bi-reporter vaccinia virus for tracking viral infections in vitro and in vivo
Chiem, K.; Lorenzo, M.; Rangel-Moreno, J.; Garcia-Hernandez, M. d. l. L.; Park, J.-G.; Nogales, A.; Blasco, R.; Martinez-Sobrido, L.
10.1101/2021.08.24.457594 — microbiology — Posted on 2021-08-26
672 From Learning to Remembering: How Memory Consolidation Differs in Term and Preterm Born Children from Young Adults
Schommartz, I.; Lembcke, P. F.; Schuetz, H.; Wald de Chamorro, N.; Bauer, M.; Kaindl, A. M.; Buss, C.; Shing, Y. L.
10.1101/2021.08.24.457558 — neuroscience — Posted on 2021-08-26
675 Top-down, knowledge-based genetic reduction of yeast central carbon metabolism
Postma, E.; Couwenberg, l.; Van Roosmalen, R. N.; Geelhoed, J.; de Groot, P.; Daran-Lapujade, P.
10.1101/2021.08.24.457526 — genetics — Posted on 2021-08-26
676 The Lambda variant of SARS-CoV-2 has a better chance than the Delta variant to escape vaccines
Liu, H.; Wei, P.; Zhang, Q.; Aviszus, K.; Linderberger, J.; Yang, J.; Liu, J.; Chen, Z.; Waheed, H.; Reynoso, L.; Downey, G.; Frankel, S.; Kappler, J.; Marrack, P.; Zhang, G.
10.1101/2021.08.25.457692 — immunology — Posted on 2021-08-26
677 Clinically-relevant T cell expansion protocols activate distinct cellular metabolic programs and phenotypes
MacPherson, S.; Keyes, S.; Kilgour, M. K.; Smazynski, J.; Sudderth, J.; Turcotte, T.; Devlieger, A.; Yu, J.; Huggler, K. S.; Cantor, J. R.; DeBerardinis, R. J.; Siatskas, C.; Lum, J. J.
10.1101/2021.08.24.457536 — immunology — Posted on 2021-08-26
678 PRMT5 promotes symmetric dimethylation of RNA processing proteins and modulates activated T cell alternative splicing and Ca2+/NFAT signaling
Sengupta, S.; West, K. O.; Sanghvi, S.; Laliotis, G.; Agosto, L. M.; Lynch, K. W.; Tsichlis, P.; Singh, H.; Patrick, K. L.; Guerau-de-Arellano, M.
10.1101/2021.08.24.457384 — immunology — Posted on 2021-08-26
679 A Scale-Free Gradient of Cognitive Resource Disruptions in Childhood Psychopathology
Stier, A. J.; Cardenas-Iniguez, C.; Kardan, O. J.; Moore, T. M.; Meyer, F. A. C.; Rosenberg, M. D.; Lahey, B. B.; Berman, M. G.
10.1101/2021.08.24.457554 — neuroscience — Posted on 2021-08-26
680 Global network structure and local transcriptomic vulnerability shape atrophy in sporadic and genetic behavioral variant frontotemporal dementia
Shafiei, G.; Bazinet, V.; Dadar, M.; Manera, A. L.; Collins, D. L.; Dagher, A.; Borroni, B.; Sanchez-Valle, R.; Moreno, F.; Laforce, R.; Graff, C.; Synofzik, M.; Galimberti, D.; Rowe, J. B.; Masellis, M.; Tartaglia, M. C.; Finger, E.; Vandenberghe, R.; de Mendonca, A.; Tagliavini, F.; Santana, I.; Butler, C.; Gerhard, A.; Danek, A.; Levin, J.; Otto, M.; Sorbi, S.; Jiskoot, L. C.; Seelaar, H.; van Swieten, J. C.; Rohrer, J. D.; Misic, B.; Ducharme, S.; Frontotemporal Lobar Degeneration Neuroimaging Initiative (FTLDNI), ; GENetic Frontotemporal dementia Initiative (GENFI),
10.1101/2021.08.24.457538 — neuroscience — Posted on 2021-08-26
682 Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania
Thomas, K. M.; Kibona, T.; Claxton, J. R.; de Glanville, W. A.; Lankester, F.; Amani, N.; Buza, J.; Carter, R. W.; Chapman, G. E.; Crump, J. A.; Dagleish, M.; Halliday, J. E. B.; Hamilton, C. M.; Innes, E. A.; Katzer, F.; Livingstone, M.; Longbottom, D.; Millins, C.; Mmbaga, B. T.; Mosha, V.; Nyarobi, J.; Nyasebwa, O.; Russell, G. C.; Sanka, P. N.; Semango, G.; Wheelhouse, N.; Willett, B. J.; Cleaveland, S.; Allan, K. J.
10.1101/2021.08.23.457407 — systems biology — Posted on 2021-08-26
683 Structural Analysis of Receptor Binding Domain Mutations in SARS-CoV-2 Variants of Concern that Modulate ACE2 and Antibody Binding
Mannar, D.; Saville, J. W.; Zhu, X.; Srivastava, S. S.; Berezuk, A. M.; Zhou, S.; Tuttle, K.; Kim, A.; Li, W.; Dimitrov, D. S.; Subramaniam, S.
10.1101/2021.08.25.457711 — biochemistry — Posted on 2021-08-26
685 Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains
Ying, B.; Whitener, B.; VanBlargan, L. A.; Hassan, A. O.; Shrihari, S.; Liang, C.-Y.; Karl, C. E.; Mackin, S.; Chen, R. E.; Kafai, N. M.; Wilks, S. H.; Smith, D. J.; Carreno, J. M.; Singh, G.; Krammer, F.; Carfi, A.; Elbashir, S.; Edwards, D. K.; Thackray, L. B.; Diamond, M. S.
10.1101/2021.08.25.457693 — microbiology — Posted on 2021-08-26
688 Structural dynamics determine voltage and pH gating in human voltage-gated proton channel
Han, S.; Peng, S.; Vance, J.; Tran, K.; Do, N.; Gates, D.; Bui, N.; Gui, Z.; Wang, S.
10.1101/2021.08.25.457625 — biophysics — Posted on 2021-08-26
697 Phosphorylated tau fluid biomarker sites recognize earlier neurofibrillary tangle maturity levels in the postmortem Alzheimer's disease brain
Moloney, C. M.; Labuzan, S. A.; Crook, J. E.; Siddiqui, H.; Castanedes-Casey, M.; Lachner, C.; Petersen, R. C.; Duara, R.; Graff-Radford, N. R.; Dickson, D. W.; Mielke, M. M.; Murray, M. E.
10.1101/2021.08.25.457363 — neuroscience — Posted on 2021-08-26
698 Genomic Surveillance of COVID-19 Variants with Language Models and Machine Learning
Nagpal, S.; Pal, R.; Ashima, ; Tyagi, A.; Tripathi, S.; Nagori, A.; Ahmad, S.; Mishra, H. P.; Kutum, R.; Sethi, T.
10.1101/2021.05.25.445601 — bioinformatics — Posted on 2021-08-26
699 Direct RNA sequencing reveals SARS-CoV-2 m6A sites and possible differential DRACH motif methylation among variants
Campos, J. H.; Maricato, J. T.; Braconi, C. T.; Antoneli, F.; Janini, L. M. R.; Briones, M. R.
10.1101/2021.08.24.457397 — genomics — Posted on 2021-08-26
700 Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2
Huang, H.-Y.; Liao, H.-Y.; Chen, X.; Wang, S.-W.; Cheng, C.-W.; Shahed-Al-Mahmud, M.; Chen, T.-H.; Lo, J. M.; Liu, Y.-M.; Wu, Y.-M.; Ma, H.-H.; Chang, Y.-H.; Tsai, H.-Y.; Chou, Y.-C.; Hsueh, Y.-P.; Tsai, C.-Y.; Huang, P.-Y.; Chang, S.-Y.; Chao, T.-L.; Kao, H.-C.; Tsai, Y.-M.; Chen, Y.-H.; Wu, C.-Y.; Jan, J.-T.; Cheng, T.-J. R.; Lin, K.-I.; Ma, C.; Wong, C.-H.
10.1101/2021.05.25.445523 — microbiology — Posted on 2021-08-26
701 Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts
Gosselin, M. R.; Mournetas, V.; Borczyk, M.; Bozycki, L.; Korostynski, M.; Robson, S.; Pinset, C.; Gorecki, D. C.
10.1101/2021.08.24.457331 — pathology — Posted on 2021-08-26
703 A genomic and morphometric analysis of alpine bumblebees: ongoing reductions in tongue length but no clear genetic component
Christmas, M. J.; Jones, J. C.; Olsson, A.; Wallerman, O.; Bunikis, I.; Kierczak, M.; Whitley, K. M.; Sullivan, I.; Geib, J. C.; Miller-Struttmann, N. E.; Webster, M. T.
10.1101/2021.03.17.435598 — evolutionary biology — Posted on 2021-08-26
704 Single cell genomics reveals plastid-lacking Picozoa are close relatives of red algae
Schön, M. E.; Zlatogursky, V. V.; Singh, R. P.; Poirier, C.; Wilken, S.; Mathur, V.; Strassert, J. F. H.; Pinhassi, J.; Worden, A. Z.; Keeling, P. J.; Ettema, T. J. G.; Wideman, J. G.; Burki, F.
10.1101/2021.04.14.439778 — evolutionary biology — Posted on 2021-08-26
705 Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants
Liao, G.; Fan, x.-x.; Lau, H.; Liu, Z.; Li, C.; Xu, Z.; Zhang, Y.; Qi, X.; Li, D.; Zhu, Q.; Chen, L.; ZHOU, H.; Zhu, S.; Ke, B.; Pan, H.; Cong, Z.; Li, Y.; Feng, Q.; Lv, Q.; Liu, J.; Liang, D.; Li, A.; Hong, W.; Li, Y.; Bao, L.; Zhou, F.; Gao, H.; liang, s.; Huang, B.; Wu, M.; Qin, C.; Ke, C.; liu, l.
10.1101/2021.08.23.456471 — immunology — Posted on 2021-08-26
706 NKCC1 modulates microglial phenotype, cerebral inflammatory responses and brain injury in a cell-autonomous manner
Toth, K.; Lenart, N.; Berki, P.; Fekete, R.; Szabadits, E.; Posfai, B.; Cserep, C.; Alatshan, A.; Benkö, S.; Kiss, D.; Hübner, C. A.; Gulyas, A.; Kaila, K.; Környei, Z.; Denes, A.
10.1101/2021.01.21.427597 — neuroscience — Posted on 2021-08-26
707 What the odor is not: Estimation by elimination
Singh, V.; Tchernookov, M.; Balasubramanian, V.
10.1101/568626 — neuroscience — Posted on 2021-08-26
711 A missense KCNQ1 Mutation Impairs Insulin Secretion in Neonatal Diabetes
Zhou, Z.; Gong, M.; Pande, A.; Lisewski, U.; Röpke, T.; Purfürst, B.; Liang, L.; Jia, S.; Frühler, S.; Margineanu, A.; Zeng, C.; Zhu, H.; Kühnen, P.; Khodaverdi, S.; Krill, W.; Chen, W.; Sander, M.; Raile, K.; Izsvak, Z.
10.1101/2021.08.24.457485 — cell biology — Posted on 2021-08-26
712 TCAB1 prevents nucleolar accumulation of the telomerase RNA to promote telomerase assembly
Al-Masraf, B. S.; Perez, G. I.; Adams-Boone, K.; Cohen, S. B.; Han, L.; Yu, K.; Schmidt, J. C.
10.1101/2021.05.27.445986 — cell biology — Posted on 2021-08-26
713 Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies
Scherer, M.; Read, C.; Neusser, G.; Kranz, C.; Müller, R.; Full, F.; Woerz, S.; Reichel, A.; Schilling, E.-M.; Walther, P.; Stamminger, T.
10.1101/2021.08.24.457524 — microbiology — Posted on 2021-08-26
715 Transcriptional profiling of the Candida auris response to exogenous farnesol exposure
Jakab, A.; Balla, N.; Ragyak, A.; Nagy, F.; Kovacs, F.; Sajtos, Z.; Borman, A. M.; Pocsi, I.; Baranyai, E.; Majoros, L.; Kovacs, R.
10.1101/2021.08.23.457447 — microbiology — Posted on 2021-08-26
716 Infection increases activity via Toll dependent and independent mechanisms in Drosophila melanogaster
Vincent, C. M.; Beckwith, E. J.; Pearson, W. H.; Kierdorf, K.; Gilestro, G.; Dionne, M. S.
10.1101/2021.08.24.457493 — immunology — Posted on 2021-08-26
718 An NLR Integrated Domain toolkit to identify plant pathogen effector targets
Landry, D.; Mila, I.; Sabbagh, C. R. R.; Zaffuto, M.; Pouzet, C.; Trenousaygue, D.; Dabos, P.; Deslandes, L.; Peeters, N.
10.1101/2021.08.23.457316 — plant biology — Posted on 2021-08-26
720 Genetic coupling of life-history and aerobic performance in juvenile Atlantic salmon
Prokkola, J. M.; Asheim, E. R.; Morozov, S.; Bangura, P.; Erkinaro, J.; Ruokolainen, A.; Primmer, C. R.; Aykanat, T.
10.1101/2021.08.23.457324 — evolutionary biology — Posted on 2021-08-26
722 LRR protein RNH1 dampens the inflammasome activation and is associated with adverse clinical outcomes in COVID-19 patients
Bombaci, G.; Sarangdhar, M. A.; Andina, N.; Tardivel, A.; Yu, E. C.-W.; Mackie, G. M.; Pugh, M.; Ozan, V. B.; Banz, Y.; Spinetti, T.; Hirzel, C.; Youd, E.; Schefold, J. C.; Taylor, G. S.; Gazdhar, A.; Bonadies, N.; Angelillo-Scherrer, A.; Schneider, P. S.; Maslowski, K. M.; Allam, R.
10.1101/2021.04.12.438219 — immunology — Posted on 2021-08-26
723 Single particle cryo-EM structure of the outer hair cell motor protein prestin
Butan, C.; Song, Q.; Bai, J.-p.; Tan, W.; Navaratnam, D. S.; Santos-Sacchi, J.
10.1101/2021.08.03.454998 — neuroscience — Posted on 2021-08-26
727 A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency
Huang, X.; Bashkenova, N.; Hong, Y.; Guallar, D.; Hu, Z.; Malik, V.; Li, D.; Shen, X.; Zhou, H.; Wang, J.
10.1101/2021.08.25.457543 — developmental biology — Posted on 2021-08-25
728 The omega-3-fatty acid docosahexaenoic acid modulates intracellular myo-inositol and its biosynthetic genes.
Murray, M.; Ok, T.; Kang, H.; Lee, J. Y.; Kim, B.; Sung, H.; Tait, T.; Colon Hidalgo, D.; Guzman, Y.
10.1101/2021.08.25.457630 — molecular biology — Posted on 2021-08-25
729 The secret life (cycle) of temperate bacteriophages
Fillol-Salom, A.; Bacigalupe, R.; Humphrey, S.; Chiang, Y. N.; Chen, J.; Penades, J.
10.1101/2021.08.25.457636 — microbiology — Posted on 2021-08-25
730 The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters
Carroll, T.; Fox, D.; van Doremalen, N.; Ball, E.; Morris, M. K.; Sotomayor-Gonzalez, A.; Servellita, V.; Rustagi, A.; Yinda, C. K.; Fritts, L.; Port, J. R.; Ma, Z.-M.; Holbrook, M.; Schulz, J.; Blish, C. A.; Hanson, C.; Chiu, C. Y.; Munster, V.; Stanley, S.; Miller, C. J.
10.1101/2021.08.25.457626 — microbiology — Posted on 2021-08-25
731 Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization
Kim, Y.; Gaudreault, N. N.; Meekins, D. A.; Perera, K. D.; Bold, D.; Trujillo, J. D.; Morozov, I.; McDowell, C. D.; Chang, K.-O.; Richt, J. A.
10.1101/2021.08.25.457627 — microbiology — Posted on 2021-08-25
733 Single-cell foundations of live social gaze interaction in the prefrontal cortex and amygdala
Dal Monte, O.; Fan, S.; Fagan, N.; Chu, C.-C.; Zhou, M.; Putnam, P.; Nair, A.; Chang, S. W. C.
10.1101/2021.08.25.457686 — neuroscience — Posted on 2021-08-25
739 Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria
Vranas, M.; Lu, Y.; Rasool, S.; Croteau, N.; Krett, J. D.; Sauve, V.; Gehring, K.; Fon, E. A.; Durcan, T. M.; Trempe, J.-F.
10.1101/2021.08.25.457684 — biochemistry — Posted on 2021-08-25
741 A compilation of fecal microbiome shotgun metagenomics from hospitalized patients undergoing hematopoietic cell transplantation
Yan, J.; Liao, C.; Taylor, B. P.; Fontana, E.; Amoretti, L. A.; Wright, R. J.; Dai, A.; Waters, N.; Peled, J. U.; Taur, Y.; Perales, M.-A.; Siranosian, B. A.; Bhatt, A. S.; van den Brink, M. R. M.; Pamer, E. G.; Schluter, J.; Xavier, J.
10.1101/2021.08.23.457365 — systems biology — Posted on 2021-08-25
744 pH-Triggered Assembly of Endomembrane Multicompartments in Synthetic Cells
Lussier, F.; Schroeter, M.; Diercks, N. J.; Jahnke, K.; Weber, C.; Frey, C.; Platzman, I.; Spatz, J. P.
10.1101/2021.08.25.457616 — synthetic biology — Posted on 2021-08-25
746 Systems-wide Analysis Revealed Shared and Unique Responses to Moderate and Acute High Temperatures in the Green Alga Chlamydomonas reinhardtii
Zhang, N.; Mattoon, E. M.; McHargue, W.; Venn, B.; Zimmer, D.; Pecani, K.; Jeong, J.; Anderson, C. M.; Chen, C.; Berry, J. C.; Xia, M.; Tzeng, S.-C.; Becker, E.; Pazouki, L.; Evans, B.; Cross, F.; Cheng, J.; Czymmek, K. J.; Schroda, M.; Muhlhaus, T.; Zhang, R.
10.1101/2021.08.17.456552 — plant biology — Posted on 2021-08-25
747 The Wood Image Analysis and Dataset (WIAD): open-access visual analysis tools to advance the ecological data revolution
Rademacher, T.; Seyednasrollah, B.; Basler, D.; Cheng, J.; Mandra, T.; Miller, E.; Lin, Z.; Orwig, D. A.; Pederson, N.; Pfister, H.; Wei, D.; Yao, L.; Richardson, A. D.
10.1101/2020.12.16.423133 — plant biology — Posted on 2021-08-25
748 Pericyte control of pancreatic islet blood flow impacts glucose homeostasis
Tamayo, A.; Goncalves, L. M.; Rodriguez-Diaz, R.; Pereira, E.; Canales, M.; Caicedo, A.; Almaca, J.
10.1101/2021.08.24.457539 — physiology — Posted on 2021-08-25
749 Discovery of novel potent, cell-permeable inhibitors of P. falciparum cGMP-dependent protein kinase.
Bheemanaboina, R. R. Y.; Gonzalez, M. L.; Mahmood, S. U.; Eck, T.; Kreiss, T.; de Souza, M. L.; Aylor, S. O.; Roth, A.; Lee, P.; Pybus, B. S.; Bhanot, P.; Colussi, D. J.; Childers, W. E.; Gordon, J.; Siekierka, J. J.; Rotella, D.
10.1101/2021.08.24.457553 — pharmacology and toxicology — Posted on 2021-08-25
751 Interactome and structural basis for targeting the human T-cell leukemia virus Tax oncoprotein
Maseko, S.; Van Molle, I.; Blibek, K.; Gorgulla, C.; Olivet, J.; Blavier, J.; Vandermeulen, C.; Skupiewski, S.; Saha, D.; Ntombela, T.; Lim, J.; Lembo, F.; Beauvois, A.; Hamaidia, M.; Borg, J.-P.; Zimmermann, P.; Delvigne, F.; Willems, L.; Van Weyenbergh, J.; Kim, D.-K.; Dequiedt, F.; Arthanari, H.; Volkov, A.; Twizere, J.-C.
10.1101/2021.08.25.457680 — biochemistry — Posted on 2021-08-25
755 Molecular Evolution across Mouse Spermatogenesis
Kopania, E. E. K.; Larson, E. L.; Callahan, C.; Keeble, S.; Good, J. M.
10.1101/2021.08.04.455131 — evolutionary biology — Posted on 2021-08-25
756 Evolution of host-microbe cell adherence by receptor domain shuffling
Baker, E. P.; Sayegh, R.; Kohler, K. M.; Borman, W.; Goodfellow, C. K.; Brush, E. R.; Barber, M. P.
10.1101/2021.08.24.457561 — evolutionary biology — Posted on 2021-08-25
759 RNA-Seq is not required to determine stable reference genes for qPCR normalization
Sampathkumar, N. K.; Sundaram, V. K.; Danthi, P. S.; Barakat, R.; Solomon, S.; Mondal, M.; Carre, I.; El Jalkh, T.; Padilla-Ferrer, A.; Grenier, J.; Massaad, C.; Mitchell, J. C.
10.1101/2021.08.21.457202 — molecular biology — Posted on 2021-08-25
761 BashTheBug: a crowd of volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates.
Fowler, P. W.; Wright, C.; Spiers, H.; Zhu, T.; Baeten, E. M.; Hoosdally, S. W.; Gibertoni Cruz, A. L.; Roohi, A.; Kouchaki, S.; Walker, T. M.; Peto, T. E.; Miller, G.; Lintott, C.; Clifton, D.; Crook, D. W.; Walker, A. S.; The Zooniverse Volunteer Community, ; The CRyPTIC Consortium,
10.1101/2021.07.20.453060 — microbiology — Posted on 2021-08-25
762 A mechanistic switch from selective transporter to an ion channel impairs the filamentation signalling capability of ammonium transceptors in yeast
Williamson, G.; Brito, A. S.; Bizior, A.; Tamburrino, G.; Mirandela, G. D.; Harris, T.; Hoskisson, P. A.; zachariae, u.; Marini, A. M.; Boeckstaens, M.; Javelle, A.
10.1101/2021.08.25.457613 — microbiology — Posted on 2021-08-25
763 Beehives possess their own distinct microbiomes
Santorelli, L.; Wilkinson, T.; Abdulmalik, R.; Rai, Y.; Creevey, C. J.; Huws, S. A.; Gutierrez-Merino, J.
10.1101/2021.08.25.457643 — microbiology — Posted on 2021-08-25
766 Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity
Du, Y.; Hertoghs, N.; Carnes, J.; McDermott, S. M.; Neal, M. L.; Schwedhelm, K. V.; McElrath, M. J.; De Rosa, S. C.; Aitchison, J. D.; Stuart, K. D.
10.1101/2021.07.28.454252 — immunology — Posted on 2021-08-25
767 A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection
Hulse, B. K.; Haberkern, H.; Franconville, R.; Turner-Evans, D. B.; Takemura, S.-y.; Wolff, T.; Noorman, M.; Dreher, M.; Dan, C.; Parekh, R.; Hermundstad, A. M.; Rubin, G. M.; Jayaraman, V.
10.1101/2020.12.08.413955 — neuroscience — Posted on 2021-08-25
768 Hippocampal replay of experience at real-world speeds
Denovellis, E. L.; Gillespie, A. K.; Coulter, M. E.; Sosa, M.; Chung, J. E.; Eden, U. T.; Frank, L. M.
10.1101/2020.10.20.347708 — neuroscience — Posted on 2021-08-25
770 Unravelling Rubber Tree Growth by Integrating GWAS and Biological Network-Based Approaches
Francisco, F. R.; Aono, A. H.; da Silva, C. C.; Gonçalves, P. d. S.; Scaloppi Júnior, E. J.; Guen, V. L.; Fritsche Neto, R.; Souza, L. M.; de Souza, A. P.
10.1101/2021.08.16.456528 — plant biology — Posted on 2021-08-25
775 Deciphering Multi-way Interactions in the Human Genome
Lindsly, S. M.; Chen, C.; Dilworth, S.; Jeyarajan, S.; Stansbury, C.; Cicalo, A.; Meixner, W.; Beckloff, N.; Ryan, C.; Surana, A.; Wicha, M.; Omenn, G.; Muir, L.; Rajapakse, I.
10.1101/2021.08.15.456363 — bioinformatics — Posted on 2021-08-25
777 CST does not evict elongating telomerase but prevents initiation by ssDNA binding
Zaug, A. J.; Lim, C. J.; Olson, C. L.; Carilli, M. T.; Goodrich, K. J.; Wuttke, D. S.; Cech, T. R.
10.1101/2021.08.25.457677 — biochemistry — Posted on 2021-08-25
779 Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism
Landen, S.; Jacques, M.; Hiam, D.; Romero, J. A.; Harvey, N. R.; Haupt, L. M.; Griffiths, L. R.; Ashton, K. J.; Lamon, S.; Voisin, S.; Eynon, N.
10.1101/2021.03.16.435733 — genomics — Posted on 2021-08-25
780 Circulation of third-generation cephalosporin resistant Salmonella Typhi in Mumbai, India
Argimon, S.; Nagaraj, G.; Shamanna, V.; Darmavaram, S.; Vasanth, A. K.; Prasanna, A.; Poojary, A.; Bari, A. K.; Underwood, A.; Kekre, M.; Baker, S.; Aanensen, D. M.; Lingegowda, R. K.
10.1101/2021.08.25.457312 — genomics — Posted on 2021-08-25
781 Platelet transcriptome yields progressive markers in chronic myeloproliferative neoplasms and identifies putative targets of therapy
Shen, Z.; Du, W.; Perkins, C.; Fechter, L.; Natu, V.; Maecker, H.; Rowley, J.; Gotlib, J.; Zehnder, J.; Krishnan, A.
10.1101/2021.03.12.435190 — genomics — Posted on 2021-08-25
783 Ancestral protein topologies draw the rooted bacterial tree of life
Dimas-Torres, J.-U.; Rodriguez-Hernandez, A.; Valencia-Sanchez, M.-I.; Campos-Chavez, E.; Godinez-Lopez, V.; Rodriguez-Chamorro, D.-E.; Grotli, M.; Fleming, C.; Hernandez-Gonzalez, A.; Arciniega, M.; Torres-Larios, A.
10.1101/2021.08.20.456953 — evolutionary biology — Posted on 2021-08-25
786 Yeast-expressed Recombinant SARS-CoV-2 Receptor Binding Domain, RBD203-N1 as a COVID-19 Protein Vaccine Candidate
Chen, W.-H.; Pollet, J.; Strych, U.; Lee, J.; Liu, Z.; Kundu, R. T.; Versteeg, L.; Villar, M. J.; Adhikari, R.; Wei, J.; Poveda, C.; Keegan, B.; Bailey, A. O.; Chen, Y.-L.; Gillespie, P. M.; Kimata, J. T.; Zhan, B.; Hotez, P. J.; Bottazzi, M. E.
10.1101/2021.08.24.457518 — molecular biology — Posted on 2021-08-25
787 Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids
Han, S.-i.; Nakakuki, M.; Nakagawa, Y.; Wang, Y.; Araki, M.; Yamamoto, Y.; Tokiwa, H.; Takeda, H.; Mizunoe, Y.; Motomura, K.; Ohno, H.; Murayama, Y.; Aita, Y.; Takeuchi, Y.; Osaki, Y.; Miyamoto, T.; Sekiya, M.; Matsuzaka, T.; Yahagi, N.; Sone, H.; Kawano, H.; Shimano, H.
10.1101/2021.08.24.457590 — molecular biology — Posted on 2021-08-25
790 Conformation of HIV-1 Envelope governs rhesus CD4 usage and simian-human immunodeficiency virus replication
Vilmen, G. V.; Smith, A. C.; Benet, H. C.; Shukla, R. K.; Larue, R. C.; Herschhorn, A.; Sharma, A.
10.1101/2021.08.25.457697 — microbiology — Posted on 2021-08-25
794 Nucleosome positioning on large tandem DNA repeats of the '601' sequence engineered in Saccharomyces cerevisiae
Lancrey, A.; Joubert, A.; Duvernois-Berthet, E.; Routhier, E.; Raj, S.; Thierry, A.; Sigarteu, M.; Ponger, L.; Croquette, V.; Mozziconacci, J.; Boule, J.-B.
10.1101/2021.08.25.457076 — synthetic biology — Posted on 2021-08-25
798 Glycation modulates glutamatergic signalling and exacerbates Parkinson's disease-like phenotypes
Chegao, A.; Guarda, M.; Alexandre, B. M.; Shvachiy, L.; Temido-Ferreira, M.; Marques-Morgado, I.; Fernandes Gomes, B.; Matthiesen, R.; Lopes, L. V.; Florindo, P. R.; Anjos-Gomes, R.; Gomes-Alves, P.; Coelho, J. E.; Outeiro, T. F.; Vicente Miranda, H.
10.1101/2021.08.24.457507 — neuroscience — Posted on 2021-08-25
799 Stochastic Consolidation of Lifelong Memory
Shaham, N.; Chandra, J.; Kreiman, G.; Sompolinsky, H.
10.1101/2021.08.24.457446 — neuroscience — Posted on 2021-08-25
800 Unique spatiotemporal fMRI dynamics in the awake mouse brain
Singh, N. A.; Gutierrez-Barragan, D.; Alvino, F.; Coletta, L.; Rocchi, F.; De Guzman, E. A.; Galbusera, A.; Panzeri, S.; Uboldi, M.; Gozzi, A.
10.1101/2021.08.24.457302 — neuroscience — Posted on 2021-08-25
801 Metformin Confers Cardiac and Renal Protection in Sudden Cardiac Arrest via AMPK Activation
Rutledge, C.; Lagranha, C.; Chiba, T.; Redding, K.; Stolz, D.; Sims-Lucas, S.; Dezfulian, C.; Elmer, J.; Kaufman, B. A.
10.1101/2021.08.24.457506 — physiology — Posted on 2021-08-25
802 High-grade Ovarian Cancer Associated H/ACA snoRNAs Promote Cancer Cell Proliferation and Survival
Faucher-Giguere, L.; Roy, A.; Deschamps-Francoeur, G.; Couture, S.; Nottingham, R. M.; Lambowitz, A. M.; Scott, M. S.; Abou Elela, S.
10.1101/2021.08.24.457387 — cancer biology — Posted on 2021-08-25
804 Assembly history modulates vertical root distribution in a grassland experiment
Alonso-Crespo, I. M.; Weidlich, E. W. A.; Temperton, V. M.; Delory, B. M.
10.1101/2021.08.24.457510 — ecology — Posted on 2021-08-25
805 A dynamic rhizosphere interplay between tree roots and soil bacteria under drought
Oppenheimer-Shaanan, Y.; Jakoby, G.; Starr, M.; Karliner, R.; Eilon, G.; Itkin, M.; Malitsky, S.; klein, t.
10.1101/2021.08.24.457490 — ecology — Posted on 2021-08-25
806 Directing an mRNA-LNP vaccine toward lymph nodes improves humoral and cellular immunity against SARS-CoV-2
Francis, D. M.; Chen, R.; Khorsandzadeh, S.; Hu, Q.; Lyu, X.; Wang, H.; Lim, W.-l.; Sun, H.; Xie, H.; Shaabani, N.; Ross, R.; Cooley, B.; Ji, H.
10.1101/2021.08.25.457699 — immunology — Posted on 2021-08-25
807 Innate and adaptive immunity to transfused allogenic red blood cells in mice requires MyD88
Soldatenko, A.; Hoyt, L. R.; Xu, L.; Calabro, S.; Lewis, S. M.; Gallman, A. E.; Hudson, K. E.; Stowell, S. R.; Luckey, C. J.; Zimring, J. C.; Liu, D.; Santhanakrishnan, M.; Hendrickson, J. E.; Eisenbarth, S. C.
10.1101/2021.08.24.457332 — immunology — Posted on 2021-08-25
809 Direct RNA sequencing reveals SARS-CoV-2 m6A sites and possible differential DRACH motif methylation among variants
Campos, J. H.; Maricato, J. T.; Braconi, C. T.; Antoneli, F.; Janini, L. M. R.; Briones, M. R.
10.1101/2021.08.24.457397 — genomics — Posted on 2021-08-25
811 Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite Brugia malayi
Airs, P. M.; Vaccaro, K.; Gallo, K. J.; Dinguirard, N.; Heimark, Z. W.; Wheeler, N. J.; He, J.; Weiss, K.; Schroeder, N. E.; Huisken, J.; Zamanian, M.
10.1101/2021.08.24.456436 — microbiology — Posted on 2021-08-25
812 Interleukin-11 plays a key role in human and mouse alcohol-related liver disease
Effenberger, M.; Grabherr, F.; Schaefer, B.; Grander, C.; Mayr, L.; Schwaerzler, J.; Enrich, B.; Moser, P.; Fink, J.; Pedrini, A.; Jaschke, N.; Freund, M.; Loizides, A.; Bale, R.; Putzer, D.; Widjaja, A. A.; Schaefer, S.; Cook, S.; Zoller, H.; Oberhuber, G.; Adolph, T. E.; Tilg, H.
10.1101/2021.08.24.456749 — immunology — Posted on 2021-08-25
813 Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes
Vazquez-Garcia, I.; Uhlitz, F.; Ceglia, N.; Lim, J. L. P.; Wu, M.; Mohibullah, N.; Ruiz, A. E. B.; Boehm, K. M.; Bojilova, V.; Fong, C. J.; Funnell, T.; Grewal, D.; Havasov, E.; Leung, S.; Pasha, A.; Patel, D. M.; Pourmaleki, M.; Rusk, N.; Shi, H.; Vanguri, R.; Williams, M. J.; Zhang, A. W.; Broach, V.; Chi, D. S.; Da Cruz Paula, A.; Gardner, G. J.; Kim, S. H.; Lennon, M.; Long Roche, K.; Sonoda, Y.; Zivanovic, O.; Kundra, R.; Viale, A.; Derakhshan, F.; Geneslaw, L.; Maroldi, A.; Nunez, R.; Pareja, F.; Stylianou, A.; Vahdatinia, M.; Bykov, Y.; Grisham, R. N.; Liu, Y. L.; Lakhman, Y.; Nikolovsk
10.1101/2021.08.24.454519 — cancer biology — Posted on 2021-08-25
817 Survival of a threatened salmon is linked to spatial variability in river conditions
Hause, C. L.; Singer, G. P.; Buchanan, R. A.; Cocherell, D. E.; Fangue, N. A.; Rypel, A. L.
10.1101/2021.08.24.456882 — ecology — Posted on 2021-08-25
818 A novel multifunctional role for Hsp70 in binding post-translational modifications on clients
Nitika, ; Zheng, B.; Ruan, L.; Kline, J.; Sikora, J.; Torres, M. T.; Wang, Y.; Takakuwa, J.; Huguet, R.; Klemm, C.; Segarra, V. A.; Winters, M.; Pryciak, P.; Thorpe, P. H.; Tatebayashi, K.; Li, R.; Fornelli, L.; Truman, A.
10.1101/2021.08.25.457671 — molecular biology — Posted on 2021-08-25
823 Calpain DEK1 acts as a developmental switch gatekeeping cell fate transitions
Demko, V.; Belova, T.; Messerer, M.; Hvidsten, T. R.; Perroud, P.-F.; Mayer, K. F. X.; Olsen, O.-A.; Lang, D.
10.1101/2021.08.25.457637 — developmental biology — Posted on 2021-08-25
824 A novel multifunctional role for Hsp70 in binding post-translational modifications on clients
Nitika, ; Zheng, B.; Ruan, L.; Kline, J.; Sikora, J.; Torres, M. T.; Wang, Y.; Takakuwa, J.; Huguet, R.; Klemm, C.; Segarra, V. A.; Winters, M.; Pryciak, P.; Thorpe, P. H.; Tatebayashi, K.; Li, R.; Fornelli, L.; Truman, A.
10.1101/2021.08.25.457671 — molecular biology — Posted on 2021-08-25
825 TopoRoot: A method for computing hierarchy and fine-grained traits of maize roots from X-ray CT images
Zeng, D.; Li, M.; Jiang, N.; Ju, Y.; Schreiber, H.; Chambers, E.; Letscher, D.; Ju, T.; Topp, C. N.
10.1101/2021.08.24.457522 — plant biology — Posted on 2021-08-25
826 Mismatch repair deficiency is not sufficient to increase tumor immunogenicity
Westcott, P. M. K.; Muyas, F.; Smith, O.; Hauck, H.; Sacks, N. J.; Ely, Z. A.; Jaeger, A. M.; Rideout, W. M.; Bhutkar, A.; Zhang, D.; Beytagh, M. C.; Canner, D. A.; Bronson, R. T.; Naranjo, S.; Jin, A.; Patten, J. J.; Cruz, A. M.; Cortes-Ciriano, I.; Jacks, T.
10.1101/2021.08.24.457572 — cancer biology — Posted on 2021-08-25
829 Hematopoiesis at single cell resolution spanning human development and maturation
Li, H.; Ezike, J.; Afanassiev, A.; Greenstreet, L.; Zhang, S. Y.; Whangbo, J.; Butty, V.; Moiso, E.; Connelly, G.; Morris, V.; Wang, D.; Daley, G. Q.; Garg, S.; Chou, S.; Regev, A.; Lummertz da Rocha, E.; Schiebinger, G.; Rowe, G.
10.1101/2021.08.25.457678 — developmental biology — Posted on 2021-08-25
830 Characterization of a novel Lbx1 loss of function mouse line
Decourtye, L.; McCallum-Loudeac, J.; Zellhuber-McMillan, S.; Young, E.; Sircombe, K. J.; Wilson, M. J.
10.1101/2021.08.25.457618 — developmental biology — Posted on 2021-08-25
832 CD72-semaphorin3A axis: a possible new player in immune regulation
Eiza, N.; Vadasz, Z.; Sabag, A.; Kessler, O.; Neufeld, G.; Jones, Y.
10.1101/2021.08.24.457482 — immunology — Posted on 2021-08-25
834 Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets
Cheng, K.; Martin-Sancho, L.; Pal, L. R.; Pu, Y.; Riva, L.; Yin, X.; Sinha, S.; Nair, N. U.; Chanda, S. K.; Ruppin, E.
10.1101/2021.01.27.428543 — systems biology — Posted on 2021-08-25
838 CDCP: a visualization and analyzing platform for single-cell datasets
Li, Y.; Yang, T.; Lai, T.; You, L.; Yang, F.; Qiu, J.; Wang, L.; Du, W.; Hua, C.; Xu, Z.; Cai, J.; Li, Z.; Liu, Y.; Li, L.; Zhang, M.; Chen, J.; Zhang, L.; Chen, D.; Liu, S.; Wu, L.; Zeng, W.; Wang, B.; Liu, L.; Chen, F.; Wei, X.
10.1101/2021.08.24.457455 — bioinformatics — Posted on 2021-08-25
842 Neutrophil-associated responses to Vibrio cholerae infection in a natural host model
Farr, D. A.; Nag, D.; Chazin, W. J.; Harrison, S. A.; Thummel, R.; Luo, X.; Raychaudhuri, S.; Withey, J. H.
10.1101/2021.08.24.457598 — microbiology — Posted on 2021-08-25
843 The cyclin Cln1 controls polyploid titan cell formation following a stress-induced G2 arrest in Cryptococcus
Altamirano, S.; Li, Z.; Fu, M. S.; Ding, M.; Fulton, S. R.; Yoder, J. M.; Tran, V.; Nielsen, K.
10.1101/2021.08.24.457603 — microbiology — Posted on 2021-08-25
845 24-nt phasiRNAs move from tapetal to meiotic cells in maize anthers
Walbot, V.; Meyers, B. C.; Zhou, X.; Huang, K.; Teng, C.; Batish, M.
10.1101/2021.08.24.457464 — plant biology — Posted on 2021-08-25
846 Systemic regulation of nitrogen acquisition and use in Oryza longistaminata ramets under nitrogen heterogeneity
Kawai, M.; Tabata, R.; Ohashi, M.; Honda, H.; Kamiya, T.; Kojima, M.; Takebayashi, Y.; Oishi, S.; Okamoto, S.; Hachiya, T.; Sakakibara, H.
10.1101/2021.08.24.457502 — plant biology — Posted on 2021-08-25
848 bletl - A Python package for integrating microbioreactors in the design-build-test-learn cycle
Osthege, M.; Tenhaef, N.; Zyla, R.; Mueller, C.; Hemmerich, J.; Wiechert, W.; Noack, S.; Oldiges, M.
10.1101/2021.08.24.457462 — bioengineering — Posted on 2021-08-25
851 CellProfiler 4: Improvements in Speed, Utility and Usability
Stirling, D. R.; Swain-Bowden, M. J.; Lucas, A. M.; Carpenter, A. E.; Cimini, B. A.; Goodman, A.
10.1101/2021.06.30.450416 — cell biology — Posted on 2021-08-25
854 Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity
Bernard, P.-L.; Delconte, R.; Pastor, S.; Laletin, V.; Costa Da Silva, C.; Goubard, A.; Josselin, E.; Castellano, R.; Krug, A.; Vernerey, J.; Devillier, R.; Olive, D.; Verhoeyen, E.; Vivier, E.; Huntington, N.; Nunes, J.; Guittard, G.
10.1101/2021.03.16.435571 — immunology — Posted on 2021-08-25
855 The Nt17 domain and its helical conformation regulate the aggregation, cellular properties and neurotoxicity of mutant huntingtin exon 1
Vieweg, S.; Mahul-Mellier, A.-L.; Ruggeri, F. S.; Riguet, N.; DeGuire, S. M.; Chiki, A.; Cendrowska, U.; Dietler, G.; Lashuel, H. A.
10.1101/2021.02.15.431207 — neuroscience — Posted on 2021-08-25
858 Knowledge Graph-based Recommendation Framework Identifies Novel Drivers of Resistance in EGFR mutant Non-small Cell Lung Cancer
Gogleva, A.; Polychronopoulos, D.; Pfeifer, M.; Poroshin, V.; Ughetto, M.; Sidders, B.; Dry, J.; Ahdesmaki, M.; McDermott, U.; Papa, E.; Bulusu, K.
10.1101/2021.07.23.453506 — cancer biology — Posted on 2021-08-25
860 Patient-Derived Three-Dimensional Cortical Neurospheres to Model Parkinson's Disease
Raja, W. K.; Neves, E.; Burke, C.; Jiang, X.; Xu, P.; Rhodes, K. J.; Khurana, V.; Scannevin, R. H.; Chung, C. Y.
10.1101/2021.08.21.457201 — neuroscience — Posted on 2021-08-25
864 A base-line cellular antiviral state is maintained by cGAS and its most frequent naturally occurring variant rs610913
Kazmierski, J.; Elsner, C.; Doehner, K.; Xu, S.; Ducroux, A.; Pott, F.; Jansen, J.; Thorball, C. W.; Zeymer, O.; Zhou, X.; Fedorov, R.; Fellay, J.; Loeffler, M. W.; Weber, A. N. R.; Sodeik, B.; Goffinet, C.
10.1101/2021.08.24.457532 — immunology — Posted on 2021-08-25
871 Spatiotemporal whole-brain dynamics of auditory patterns recognition
Bonetti, L.; Brattico, E.; Carlomagno, F.; Cabral, J.; Stevner, A.; Deco, G.; Whybrow, P. C.; Pearce, M.; Pantazis, D.; Vuust, P.; Kringelbach, M. L.
10.1101/2020.06.23.165191 — neuroscience — Posted on 2021-08-25
872 Substrate dynamics contribute to enzymatic specificity in human and bacterial methionine adenosyltransferases
GADE, M. H.; Tan, L. L.; Damry, A. M.; Sandhu, M.; Brock, J. S.; Delaney, A.; Villar-Briones, A.; Jackson, C. J.; Laurino, P.
10.1101/2021.02.18.431797 — biochemistry — Posted on 2021-08-25
882 Ancestral protein topologies draw the rooted bacterial tree of life
Dimas-Torres, J.-U.; Rodriguez-Hernandez, A.; Valencia-Sanchez, M.-I.; Campos-Chavez, E.; Godinez-Lopez, V.; Rodriguez-Chamorro, D.-E.; Grotli, M.; Fleming, C.; Hernandez-Gonzalez, A.; Arciniega, M.; Torres-Larios, A.
10.1101/2021.08.20.456953 — evolutionary biology — Posted on 2021-08-24
883 An Essential Role of UBXN3B in B Lymphopoiesis
Geng, T.; Yang, D.; Lin, T.; Harrison, A. G.; Wang, B.; Torrance, B.; Wang, K.; Wang, Y.; Yang, L.; Haynes, L.; Cheng, G.; Vella, A. T.; Fikrig, E.; WANG, P.
10.1101/2021.03.04.433919 — immunology — Posted on 2021-08-24
888 PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia
Smith, B. M.; VanCampen, J.; Kong, G. L.; Yashar, W.; Horton, W.; Coleman, D. J.; Estabrook, J.; Lusardi, T. A.; Druker, B. J.; Maxson, J. E.; Braun, T. P.
10.1101/2021.08.24.456354 — cancer biology — Posted on 2021-08-24
889 Spontaneous emergence of non-convertible cell states with CD24-High phenotype results in phenotypic heterogeneity that associates with poor prognosis in oral cancer
Vipparthi, K.; Hari, K.; Chakraborty, P.; Ghosh, S.; Patel, A.; Ghosh, A.; Biswas, N. K.; Sharan, R.; Arun, P.; Jolly, M. K.; Singh, S.
10.1101/2021.08.24.457509 — cancer biology — Posted on 2021-08-24
893 Long-read and chromosome-scale assembly of the hexaploid wheat genome achieves higher resolution for research and breeding
Aury, J.-M.; Engelen, S.; Istace, B.; Monat, C.; Lasserre-Zuber, P.; Belser, C.; Cruaud, C.; Rimbert, H.; Leroy, P.; Arribat, S.; Dufau, I.; Bellec, A.; Grimbichler, D.; Papon, N.; Paux, E.; Ranoux, M.; Alberti, A.; Wincker, P.; Choulet, F.
10.1101/2021.08.24.457458 — genomics — Posted on 2021-08-24
894 Inferring and perturbing cell fate regulomes in human cerebral organoids
Fleck, J. S.; Jansen, S. M.; Wollny, D.; Seimiya, M.; Zenk, F.; Santel, M.; He, Z.; Camp, J. G.; Treutlein, B.
10.1101/2021.08.24.457460 — developmental biology — Posted on 2021-08-24
895 Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
Duan, L.; Zaepfel, B.; Aksenova, V.; Dasso, M.; Rothstein, J.; Kalab, P.; Hayes, L. R.
10.1101/2021.08.24.457459 — cell biology — Posted on 2021-08-24
896 Defining dysfunction due to loss of MECP2 in Rett Patient Brain
Korsakova, E.; Morales, A.; McDaniel, T.; Lund, A.; Cooper, B.; Ma, F.; Allison, T.; Plath, K.; Graham, N. A.; Bhaduri, A.; Lowry, W.
10.1101/2021.08.24.457297 — molecular biology — Posted on 2021-08-24
898 AgMESH, a peritrophic matrix-associated protein embedded in Anopheles gambiaemelanotic capsules modulates malaria parasite infection
Camacho, E.; Dong, Y.; Anglero-Rodriguez, Y.; Smith, D.; Jacomini, R. S.; McConnell, S. A.; Dimopoulos, G.; Casadevall, A.
10.1101/2021.05.07.443077 — microbiology — Posted on 2021-08-24
900 Multi-omics investigation of Clostridioides difficile-colonized patients reveals protective commensal carbohydrate metabolism
Fishbein, S. R. S.; Robinson, J. I.; Hink, T.; Reske, K. A.; Newcomer, E. P.; D. Burnham, C.-A.; Henderson, J. P.; Dubberke, E. R.; Dantas, G.
10.1101/2021.08.24.457492 — microbiology — Posted on 2021-08-24
902 High Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium
van Rijn, J. M.; Eriksson, J.; Grüttner, J.; Sundbom, M.; Webb, D.-L.; Hellström, P. M.; Svärd, S. G.; Sellin, M. E.
10.1101/2021.08.24.457471 — microbiology — Posted on 2021-08-24
903 Host ecology regulates interspecies recombination in bacteria of the genus Campylobacter
Mourkas, E.; Yahara, K.; Bayliss, S. C.; Calland, J. K.; Johansson, H.; Mageiros, L.; Munoz-Ramirez, Z. Y.; Futcher, G.; Meric, G.; Hitchings, M. D.; Sandoval-Motta, S.; Torres, J.; Jolley, K. A.; Maiden, M. C.; Ellstrom, P.; Waldenstrom, J.; Pascoe, B.; Sheppard, S. K.
10.1101/2021.08.24.457495 — microbiology — Posted on 2021-08-24
906 Key Drivers of Ecological Assembly in the Hindgut of Atlantic Cod (Gadus morhua) when Fed with a Macroalgal Supplemented diet - How Robust Is the Gut to Taxonomic Perturbation?
Keating, C.; bolton-warberg, m.; Hinchcliffe, J.; Davies, R.; Whelan, S.; Wan, A. H. L.; Fitzgerald, R.; Davies, S. J.; Smith, C. J.; Ijaz, U. Z. Z.
10.1101/2021.08.24.457479 — microbiology — Posted on 2021-08-24
907 The AIRE G228W mutation results in a longer-lasting AIRE-SIRT1 interaction
Santos, J. C.; Dametto, M.; Masson, A. P.; Faca, V. M.; Bonacin, R.; Donadi, E. A.; Passos, G. A.
10.1101/2021.08.24.457565 — immunology — Posted on 2021-08-24
908 A base-line cellular antiviral state is maintained by cGAS and its most frequent naturally occurring variant rs610913
Kazmierski, J.; Elsner, C.; Doehner, K.; Xu, S.; Ducroux, A.; Pott, F.; Jansen, J.; Thorball, C. W.; Zeymer, O.; Zhou, X.; Fedorov, R.; Fellay, J.; Loeffler, M. W.; Weber, A. N. R.; Sodeik, B.; Goffiner, C.
10.1101/2021.08.24.457532 — immunology — Posted on 2021-08-24
909 Immunization with SARS-CoV-2 nucleocapsid protein triggers a pulmonary immune response in rats
Silva, E. K. V. B.; Bomfim, C. G.; Barbosa, A. P.; Noda, P.; Noronha, I. L.; Fernandes, B. H. V.; Machado, R. R. G.; Durigon, E. L.; Catanozi, S.; Rodrigues, L. G.; Pieroni, F.; Lima, S.; Queiroz, Z. A. J.; Charlie-Silva, I.; Silveira, L. K. R.; Teodoro, W. T.; Capelozzi, V. L.; Guzzo, C. R.; Fanelli, C.
10.1101/2021.08.24.457520 — immunology — Posted on 2021-08-24
910 Single particle cryo-EM structure of the outer hair cell motor protein prestin
Butan, C.; Song, Q.; Bai, J.-p.; Tan, W.; Navaratnam, D. S.; Santos-Sacchi, J.
10.1101/2021.08.03.454998 — neuroscience — Posted on 2021-08-24
911 Sensory experience selectively reorganizes the late component of evoked responses
Bermudez Contreras, E.; Gomez Palacio-Schjetnan, A.; Luczak, A.; Mohajerani, M. H.
10.1101/2020.09.30.321547 — neuroscience — Posted on 2021-08-24
912 A multiscale spatiotemporal model explains succession in the early infant gut microbiota as a switch from aerobic to anaerobic metabolism
Versluis, D. M.; Schoemaker, R.; Looijesteijn, E.; Muysken, D.; Jeurink, P. V.; Paques, M.; Geurts, J. M. W.; Merks, R. M. H.
10.1101/2021.08.22.457032 — systems biology — Posted on 2021-08-24
913 A modular platform for on-demand vaccine self-assembly enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens
Weyant, K. B.; Liao, J.; Rivera-De Jesus, M.; Jaroentomeechai, T.; Moeller, T. D.; Hoang-Phou, S.; Pal, S.; Gilmore, S. F.; Singh, R.; Putnam, D.; Locher, C.; de la Maza, L.; Coleman, M.; DeLisa, M. P.
10.1101/2021.08.24.457488 — synthetic biology — Posted on 2021-08-24
915 The quasi-universality of nestedness in the structure of quantitative plant-parasite interactions
Moury, B.; Audergon, J.-M.; Baudracco-Arnas, S.; BEN KRIMA, S.; Bertrand, F.; Boissot, N.; Buisson, M.; Caffier, V.; Cantet, M.; Chaneac, S.; Constant, C.; Delmotte, F.; Dogimont, C.; Doumayrou, J.; Fabre, F.; Fournet, S.; Grimault, V.; Jaunet, T.; Justafre, I.; Lefebvre, V.; Losdat, D.; MARCEL, T. C.; Montarry, J.; Morris, C. E.; Omrani, M.; Paineau, M.; Perrot, S.; Pilet-Nayel, M.-L.; Ruellan, Y.
10.1101/2021.03.03.433745 — pathology — Posted on 2021-08-24
916 CULTURE AND MAINTENANCE OF URINE-DERIVED, 3-DIMENSIONAL CANINE TRANSITIONAL CELL CARCINOMA ORGANOIDS
Thenuwara, S.; Schneider, B.; Mosichuk, A.; Gabriel, V.; Zdyrski, C.; Dao, K.; Iennarella-Servantez, C.; Colosimo, M.; Sahoo, D.; Bourgois-Mochel, A.; Musser, M.; Johannes, C.; Palerme, J.-S.; Allenspach, K.; Mochel, J. P.
10.1101/2021.08.24.457548 — cancer biology — Posted on 2021-08-24
917 MEOX2 homeobox gene promotes growth of malignant gliomas
Turcan, S.; Schönrock, A.; Heinzelmann, E.; Steffl, B.; Narayanan, A.; Krunic, D.; Bähr, M.; Park, J.-W.; Schmidt, C.; Ozduman, K.; Pamir, N. M.; Wick, W.; Bestvater, F.; Weichenhan, D.; Plass, C.; Taranda, J.; Mall, M.
10.1101/2021.08.24.457477 — cancer biology — Posted on 2021-08-24
919 Gene Expression Risk Scores for COVID-19 Illness Severity
Peterson, D. R.; Baran, A. M.; Bhattacharya, S.; Branche, A. R.; Croft, D. P.; Corbett, A. M.; Walsh, E. E.; Falsey, A. R.; Mariani, T. J.
10.1101/2021.08.24.457521 — genomics — Posted on 2021-08-24
921 New insights into the evolution of SPX gene family from algae to legumes; a focus on soybean
Chegini, M. N.; Ebrahimie, E.; Tahmasebi, A.; Moghadam, A.; Eshghi, S.; Mohammadi-Dehchesmeh, M.; Kopriva, S.; Niazi, A.
10.1101/2021.08.24.457498 — evolutionary biology — Posted on 2021-08-24
923 DNA methylation in Ensifer species during free-living growth and during nitrogen-fixing symbiosis with Medicago spp.
diCenzo, G. C.; Cangioli, L.; Nicoud, Q.; Cheng, J. H. T.; Blow, M. J.; Shapiro, N.; Woyke, T.; Biondi, E. G.; Alunni, B.; Mengoni, A.; Mergaert, P.
10.1101/2021.03.08.434416 — microbiology — Posted on 2021-08-24
924 Establishment of quantitative RNAi-based forward genetics in Entamoeba histolytica and identification of genes required for growth
Bettadapur, A.; Hunter, S. S.; Suleiman, R. L.; Ruyechan, M. C.; Huang, W.; Barbieri, C. G.; Settles, M. L.; Ralston, K. S.
10.1101/2020.05.28.121780 — microbiology — Posted on 2021-08-24
925 Force-induced changes of PilY1 drive surface sensing by Pseudomonas aeruginosa
Webster, S.; Mathelie-Guinlet, M.; Verissimo, A.; Schultz, D.; Viljoen, A.; Lee, C. K.; Schmidt, W. C.; Wong, G.; Dufrene, Y.; OToole, G.
10.1101/2021.08.24.457478 — microbiology — Posted on 2021-08-24
926 Eye movements elevate crowding in idiopathic infantile nystagmus syndrome
Tailor, V. K.; Theodorou, M.; Dahlmann-Noor, A. H.; Dekker, T. M.; Greenwood, J. A.
10.1101/2021.01.16.426927 — neuroscience — Posted on 2021-08-24
931 Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display
Johansen-Leete, J.; Ullrich, S.; Fry, S.; Frkic, R.; Bedding, M.; Aggarwal, A.; Ashhurst, A.; Ekanayake, K.; Mahawaththa, M.; Sasi, V.; Passioura, T.; Larance, M.; Otting, G.; Turville, S. G.; Jackson, C. J.; Nitsche, C.; Payne, R. J.
10.1101/2021.08.23.457419 — biochemistry — Posted on 2021-08-24
933 Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption
Ren, W.; Lan, J.; Ju, X.; Gong, M.; Long, Q.; Zhu, Z.; Yu, Y.; Wu, J.; Zhong, J.; Zhang, R.; Fan, S.; Zhong, G.; Huang, A.; Wang, X.; Ding, Q.
10.1101/2021.08.24.457448 — microbiology — Posted on 2021-08-24
935 Spectral fiber-photometry derives hemoglobin-absorption changes for accurate measurement of fluorescent sensors
Zhang, W.-T.; Chao, T.-H. H.; Yang, Y.; Wang, T.-W.; Lee, S.-H.; Oyarzabal, E. A.; Zhou, J.; Nonneman, R.; Pegard, N. C.; Zhu, H.; Cui, G.; Shih, Y.-Y. I.
10.1101/2021.08.23.457372 — neuroscience — Posted on 2021-08-24
940 Asymmetric depth-filtration - a versatile and scalable approach for isolation and purification of extracellular vesicles
Chernyshev, V. S.; Chuprov-Netochin, R. N.; Tsydenzhapova, E.; Svirshchevskaya, E. V.; Poltavtseva, R. A.; Merdalimova, A.; Yashchenok, A.; Keshelava, A.; Sorokin, K.; Keshelava, V.; Sukhikh, G. T.; Gorin, D.; Leonov, S.; Skliar, M.
10.1101/2021.08.23.457333 — bioengineering — Posted on 2021-08-24
941 Cryo-EM structure of the human TACAN channel in a closed state
chen, x.; Wang, Y.; Li, Y.; Lu, X.; chen, j.; Li, M.; Wen, T.; liu, n.; Chang, S.; Zhang, X.; Yang, X.; Shen, Y.
10.1101/2021.08.23.457436 — biochemistry — Posted on 2021-08-24
942 Isolation and Genomics of multidrug-resistant Brevundimonas diminuta collected from patients with pertussis-like symptoms
Safarchi, A.; Nikbin, V. S.; Nakhost Lotfi, M.; Saedi, S.; Sedaghatpour, M.; Lamichhane, B.; Dinarvand, M.; Tay, C. Y.; Shahcheraghi, F.
10.1101/2021.08.23.457371 — genomics — Posted on 2021-08-24
943 Transcriptional plasticity drives leukemia immune escape
Eagle, K.; Harada, T.; Kalfon, J.; Perez, M.; Heshmati, Y.; Ewers, J.; Vrabic Koren, J.; Dempster, J. M.; Kugener, G.; Paralkar, V. R.; Lin, C. Y.; Dharia, N. V.; Stegmaier, K.; Orkin, S. H.; Pimkin, M.
10.1101/2021.08.23.457351 — genomics — Posted on 2021-08-24
944 The Chloroflexi supergroup is metabolically diverse and representatives have novel genes for non-photosynthesis based CO2 fixation
West-Roberts, J. A.; Matheus Carnevali, P. B.; Scholmerich, M. C.; Al-Shayeb, B.; Thomas, A.; Sharrar, A. M.; He, C. Y.; Chen, L.-X.; Lavy, A.; Keren, R.; Amano, Y.; Banfield, J.
10.1101/2021.08.23.457424 — microbiology — Posted on 2021-08-24
946 A deep learning-based iterative digital pathology annotation tool
Jaber, M. I.; Song, B.; Beziaeva, L.; Szeto, C. W.; Spilman, P.; Yang, P.; Soon-Shiong, P.
10.1101/2021.08.23.457396 — pathology — Posted on 2021-08-24
948 Belowground allocation and dynamics of recently fixed plant carbon in a California annual grassland soil
Fossum, C.; Estera-Molina, K.; Yuan, M.; Herman, D.; Chu-Jacoby, I.; Nico, P.; Morrison, K.; Pett-Ridge, J.; Firestone, M. K.
10.1101/2021.08.23.457405 — biochemistry — Posted on 2021-08-24
950 Converging evidence for differential regulatory control of APOEε4 on African versus European haplotypes
Nuytemans, K.; LipkinVasquez, M.; Wang, L.; Van Booven, D.; Griswold, A. J.; Rajabli, F.; Celis, K.; Oron, O.; Hofmann, N.; Rolati, S.; Garcia-Serje, C.; Zhang, S.; Jin, F.; Argenziano, M.; Grant, S. F.; Chesi, A.; Brown, C. D.; Young, J. I.; Dykxhoorn, D. M.; Pericak-Vance, M. A.; Vance, J. M.
10.1101/2021.08.23.457375 — genomics — Posted on 2021-08-24
953 Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration
Cao, Y.; Xia, Y.; Balowski, J. B.; ou, j.; Song, L.; Safi, A.; Curtis, T.; Crawford, G. E.; Poss, K. D.; Cao, J.
10.1101/2021.08.23.457406 — developmental biology — Posted on 2021-08-24
954 Cell Sex and Sex Hormones Modulate Kidney Glucose and Glutamine Metabolism in Health and Diabetes
Clotet-Freixas, S.; Zaslaver, O.; Pastrello, C.; Kotlyar, M.; McEvoy, C. M.; Farkona, S.; Saha, A.; Boshart, A.; Chan, M.; Riera, M.; Soler, M. J.; Isenbrandt, A.; Lamontagne-Proulx, J.; Pradeloux, S.; Coulombe, K.; Soulet, D.; Dart, A. B.; Wicklow, B.; McGavock, J. M.; Blydt-Hansen, T. D.; Jurisica, I.; Woo, M.; Scholey, J. W.; Rost, H.; Konvalinka, A.
10.1101/2021.08.23.457385 — cell biology — Posted on 2021-08-24
956 LRRK2 causes centrosomal deficits via phosphorylated Rab10 and RILPL1 at centriolar subdistal appendages
Ordonez, A. J. L.; Fernandez, B.; Fasiczka, R.; Naaldijk, Y.; Fdez, E.; Blanca Ramirez, M.; Phan, S.; Boassa, D.; Hilfiker, S.
10.1101/2021.08.23.457380 — neuroscience — Posted on 2021-08-24
958 CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states
Leng, K.; Rooney, B.; Kim, H.; Xia, W.; Koontz, M.; Krawczyk, M.; Zhang, Y.; Ullian, E. M.; Fancy, S. P. J.; Schrag, M. S.; Lippmann, E. S.; Kampmann, M.
10.1101/2021.08.23.457400 — neuroscience — Posted on 2021-08-24
959 A compilation of fecal microbiome shotgun metagenomics from hospitalized patients undergoing hematopoietic cell transplantation
Yan, J.; Liao, C.; Taylor, B. P.; Fontana, E.; Amoretti, L. A.; Wright, R. J.; Dai, A.; Waters, N.; Peled, J. U.; Taur, Y.; Perales, M.-A.; Siranosian, B. A.; Bhatt, A. S.; van den Brink, M. R. M.; Pamer, E. G.; Schluter, J.; Xavier, J.
10.1101/2021.08.23.457365 — systems biology — Posted on 2021-08-24
960 Experimental safety testing shows that the NSAID tolfenamic acid is not toxic to Gyps vultures in India at concentrations likely to be encountered in cattle carcasses
S., C.; Mallord, J. W.; Manickam, K.; Sharma, A. K.; Mahendran, K.; Gupta, R.; Chutia, K.; Mathes, K.; Pawde, A.; Prakash, N. V.; P., R.; Saikia, D.; Shringarpure, R.; Timung, A.; Galligan, T. H.; Green, R. E.; Prakash, V. M.
10.1101/2021.08.23.456758 — pharmacology and toxicology — Posted on 2021-08-24
961 Counterbalance of Foxp3 and IDO expression at different tumor stages in aggressive breast cancer subtypes
Canzoneri, R.; Lacunza, E.; Rabassa, M. E.; Cavalli, F. A.; Ferretti, V. A.; Barbera, L. A.; Creton, A.; Croce, M. V.; Isla Larrain, M. T.
10.1101/2021.08.23.457395 — cancer biology — Posted on 2021-08-24
962 proovframe: frameshift-correction for long-read (meta)genomics
Hackl, T.; Trigodet, F.; Eren, A. M.; Biller, S. J.; Eppley, J. M.; Luo, E.; Burger, A.; DeLong, E. F.; Fischer, M. G.
10.1101/2021.08.23.457338 — bioinformatics — Posted on 2021-08-24
964 Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19
Lam, M. T. Y.; Duttke, S. H.; Odish, M. F.; Le, H. D.; Hansen, E. A.; Nguyen, C. T.; Trescott, S.; Kim, R.; Deota, S.; Chang, M. W.; Patel, A.; Hepokoski, M.; Alotaibi, M.; Rolfsen, M.; Perofsky, K.; Warden, A. S.; Foley, J.; Ramirez, S. I.; Dan, J. M.; Abbott, R.; Crotty, S.; Crotty-Alexander, L. E.; Malhotra, A.; Panda, S.; Benner, C. W.; Coufal, N. G.
10.1101/2021.08.24.457187 — genomics — Posted on 2021-08-24
966 TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia
Jairaman, A.; McQuade, A.; Kang, Y. J.; Granzotto, A.; Chadarevian, J. P.; Gandhi, S.; Parker, I.; Smith, I.; Othy, S.; Cho, H.; Blurton-Jones, M.; Cahalan, M. D.
10.1101/2021.08.24.457491 — neuroscience — Posted on 2021-08-24
970 Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells
Zhu, Y.; Chew, K. Y.; Karawita, A. C.; Yamamoto, A.; Labzin, L. L.; Yarlagadda, T.; Khromykh, A. A.; Stocks, C. J.; Xia, Y.; Kollmann, T. R.; Martino, D.; Kicic, A.; Joensuu, M.; Meunier, F. A.; Balistreri, G.; Bielefeldt-Ohmann, H.; Bowen, A. C.; Sly, P. D.; Spann, K. M.; Short, K. R.
10.1101/2021.03.08.434300 — microbiology — Posted on 2021-08-24
971 Infection and transmission of ancestral SARS-CoV-2 and its alpha variant in pregnant white-tailed deer
Cool, K.; Gaudreault, N. N.; Morozov, I.; Trujillo, J. D.; Meekins, D. A.; McDowell, C.; Carossino, M.; Bold, D.; Kwon, T.; Balaraman, V.; Madden, D. W.; Libanori Artiaga, B.; Pogranichniy, R. M.; Roman Sosa, G.; Henningson, J.; Wilson, W. C.; Balasuriya, U. B. R.; Garcia-Sastre, A.; Richt, J. A.
10.1101/2021.08.15.456341 — microbiology — Posted on 2021-08-24
973 Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant
Liu, Y.; Liu, J.; Johnson, B. A.; Xia, H.; Ku, Z.; Schindewolf, C.; Widen, S. G.; An, Z.; Weaver, S.; Menachery, V. D.; Xie, X.; Shi, P.-Y.
10.1101/2021.08.12.456173 — microbiology — Posted on 2021-08-24
974 Repurposing melanoma chemotherapy to activate inflammasomes in treatment of BRAF/MAPK inhibitor-resistant melanoma
Ahmed, F.; Tseng, H.-Y.; Ahn, A.; Gunatilake, D.; Alavi, S.; Eccles, M.; Rizos, H.; Gallagher, S.; TIFFEN, J.; Hersey, P.; Emran, A. A.
10.1101/2021.08.23.457344 — cancer biology — Posted on 2021-08-24
975 The emergence of highly fit SARS-CoV-2 variants accelerated by epistasis and caused by recombination
Garvin, M. R.; Prates, E. T.; Romero, J.; Cliff, A.; Gazolla, J. G. F. M.; Pickholz, M.; Pavicic, M.; Jacobson, D.
10.1101/2021.08.03.454981 — evolutionary biology — Posted on 2021-08-24
979 Cyclic loading regime considered beneficial does not protect injured and interleukin-1-inflamed cartilage from post-traumatic osteoarthritis
Eskelinen, A. S. A.; Florea, C.; Tanska, P.; Hung, H.-H. K.; Frank, E. H.; Mikkonen, S.; Nieminen, P.; Julkunen, P.; Grodzinsky, A. J.; Korhonen, R. K.
10.1101/2021.08.23.457262 — pathology — Posted on 2021-08-24
981 Dandelion pappus morphing is actuated by radially patterned material swelling
Seale, M.; Kiss, A.; Bovio, S.; Viola, I. M.; Mastropaolo, E.; Boudaoud, A.; Nakayama, N.
10.1101/2021.08.23.457337 — bioengineering — Posted on 2021-08-24
982 A Recurring Chemogenetic Switch for Chimeric Antigen Receptor T Cells
Cao, W.; Geng, Z.; Wang, N.; Pan, Q.; Guo, S.; Xu, S.; Zhou, J.; Liu, W. R.
10.1101/2021.08.23.457355 — bioengineering — Posted on 2021-08-24
984 Genetic coupling of life-history and aerobic performance in juvenile Atlantic salmon
Prokkola, J. M.; Asheim, E. R.; Morozov, S.; Bangura, P.; Erkinaro, J.; Ruokolainen, A.; Primmer, C. R.; Aykanat, T.
10.1101/2021.08.23.457324 — evolutionary biology — Posted on 2021-08-24
985 Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis
Hanasoge Somasundara, A. V.; Moss, M. A.; Feigman, M. J.; Chen, C.; Cyrill, S. L.; Ciccone, M. F.; Trousdell, M. C.; Vollbrecht, M.; Li, S.; Kendall, J.; Beyaz, S.; Wilkinson, J. E.; Dos Santos, C. O.
10.1101/2021.08.23.457350 — developmental biology — Posted on 2021-08-24
986 Insulin Signaling Attenuates GLUT4 Endocytosis in Muscle Cells via GSK3a-Dyn2-Bin1 Interplay
Liu, Y.-W.; Laiman, J.; Loh, J.; Tang, W.-C.; Chuang, M.-C.; Chen, B.-C.; Chang, Y.-C.; Chuang, L.-M.
10.1101/2021.08.23.457303 — cell biology — Posted on 2021-08-24
987 Electrophysiological markers of fairness and selfishness revealed by a combination of Dictator and Ultimatum Games
Miraghaie, A. M.; Pouretemad, H.; Villa, A. E. P.; Mazaheri, M. A.; Khosrowabadi, R.; Lintas, A.
10.1101/2021.08.23.457310 — neuroscience — Posted on 2021-08-24
991 A universal approach for integrating super large-scale single-cell transcriptomes by exploring gene rankings
Shen, H.; Shen, X.; Feng, M.; Wu, D.; Zhang, C.; Yang, Y.; Yang, M.; Hu, J.; Liu, J.; Wang, W.; Li, Y.; Zhang, Q.; Yang, J.; Chen, K.; Li, X.
10.1101/2021.08.23.457305 — bioinformatics — Posted on 2021-08-24
997 FEDERATED MORPHOMETRY FEATURE SELECTION FOR HIPPOCAMPAL MORPHOMETRY ASSOCIATED BETA-AMYLOID AND TAU PATHOLOGY
Wu, J.; Dong, Q.; Zhang, J.; Su, Y.; Wu, T.; Caselli, R. J.; Reiman, E. M.; Ye, J.; Lepore, N.; Chen, K.; Thompson, P. M.; Wang, Y.
10.1101/2021.08.22.457269 — neuroscience — Posted on 2021-08-24
998 An isogenic panel of single App knock-in mouse models of Alzheimer's disease confers differential profiles of β-secretase inhibition and endosomal abnormalities
Watamura, N.; Sato, K.; Shiihashi, G.; Iwasaki, A.; Kamano, N.; Takahashi, M.; Sekiguchi, M.; Yamazaki, N.; Fujioka, R.; Nagata, K.; Ohshima, T.; Saito, T.; Saido, T. C.; Sasaguri, H.
10.1101/2021.08.22.457278 — neuroscience — Posted on 2021-08-24
999 Neprilysin-sensitive amyloidogenic Aβ versus IDE-sensitive soluble Aβ: a probable mechanistic cause for sporadic Alzheimer's disease
Sasaguri, H.; Takamura, R.; Watamura, N.; Fujioka, R.; Sekiguchi, M.; Yamazaki, N.; Kakiya, N.; Watanabe, K.; Matsuba, Y.; Hashimoto, S.; Ohshima, T.; Saito, T.; Iwata, N.; Saido, T. C.
10.1101/2021.08.22.457281 — neuroscience — Posted on 2021-08-24
1003 Vapor cannabis exposure generationally affects male reproductive functions in mice
Shi, M.; Langholt, E. M.; Butler, L. C.; Harvey, M. E.; Wheeler, E. C.; Zhao, L.; MacLean, J. A.; Oh, Y.; Sabrowsky, E. J.; Yu, S.; Watson, S. A.; Davis, J. F.; Hayashi, K.
10.1101/2021.08.22.457271 — pharmacology and toxicology — Posted on 2021-08-24
1004 Nanomechanics combined with HDX reveal allosteric drug binding sites of CFTR NBD1
Padanyi, R.; Farkas, B.; Tordai, H.; Kiss, B.; Grubmuller, H.; Soya, N.; Lukacs, G.; Kellermayer, M.; Hegedus, T.
10.1101/2021.08.20.457065 — biophysics — Posted on 2021-08-24
1007 Plasma Contains Ultra-short Single-stranded DNA in Addition to Nucleosomal cfDNA
Cheng, J. C.; Morselli, M.; Huang, W.-L.; Heo, Y. J.; Pinheiro-Ferreira, T.; Li, F.; Wei, F.; Chia, D.; He, H.-J.; Cole, K.; Su, W.-C.; Pellegrini, M.; Wong, D. T.
10.1101/2021.08.22.457243 — genomics — Posted on 2021-08-24
1015 Visualization of seasonal phosphorus re-translocation, and expression profile of phosphate transporters in a shortened annual cycle system of the deciduous poplar tree
Kurita, Y.; Kanno, S.; Sugita, R.; Hirose, A.; Ohnishi, M.; Tezuka, A.; Deguchi, A.; Ishizaki, K.; Fukaki, H.; Baba, K.; Nagano, A. J.; Tanoi, K.; Nakanishi, T. M.; Mimura, T.
10.1101/2020.04.12.038562 — plant biology — Posted on 2021-08-24
1016 ATF-4 and hydrogen sulfide signalling mediate longevity from inhibition of translation or mTORC1
Statzer, C.; Meng, J.; Venz, R.; Bland, M.; Robida-Stubbs, S.; Patel, K.; Petrovic, D.; Emsley, R.; Liu, P.; Morantte, I.; Haynes, C.; Mair, W. B.; Longchamp, A.; Filipovic, M.; Blackwell, T. K.; Ewald, C. Y.
10.1101/2020.11.02.364703 — physiology — Posted on 2021-08-24
1018 Reconstructing hunter-gatherer planet Earthusing machine-learning
Hamilton, M. J.; Walker, R. S.; Buchanan, B.; Blasi, D. E.; Bowern, C.
10.1101/2021.08.21.457222 — ecology — Posted on 2021-08-24
1020 Deep immune profiling of the maternal-fetal interface with mild SARS-CoV-2 infection
Sureshchandra, S.; Zulu, M. Z.; Doratt, B.; Jankeel, A.; Tifrea, D.; Edwards, R. A.; Rincon, M.; Marshall, N. E.; Messaoudi, I.
10.1101/2021.08.23.457408 — immunology — Posted on 2021-08-23
1021 Colicin E1 opens its hinge to plug TolC
Budiardjo, S. J.; Stevens, J. J.; Calkins, A. L.; Ikujuni, A. P.; Wimalasena, V. K.; Firlar, E.; Case, D.; Biteen, J. S.; Kaelber, J.; Slusky, J. S. G.
10.1101/692251 — biophysics — Posted on 2021-08-24
1022 Intra-host SARS-CoV-2 evolution in the gut of mucosally-infected Chlorocebus aethiops (African green monkeys)
Rowe, L. A.; Beddingfield, B. J.; Goff, K.; Killeen, S. Z.; Chirichella, N. R.; Melton, A.; ROY, C. J.; Maness, N. J.
10.1101/2021.08.22.457295 — microbiology — Posted on 2021-08-23
1023 mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern
Goel, R. R.; Painter, M. M.; Apostolidis, S. A.; Mathew, D.; Meng, W.; Rosenfeld, A. M.; Lundgreen, K. A.; Reynaldi, A.; Khoury, D. S.; Pattekar, A.; Gouma, S.; Kuri-Cervantes, L.; Hicks, P.; Dysinger, S.; Hicks, A.; Sharma, H.; Herring, S.; Korte, S.; Baxter, A. E.; Oldridge, D. A.; Giles, J. R.; Weirick, M. E.; McAllister, C. M.; Awofolaju, M.; Tanenbaum, N.; Drapeau, E. M.; Dougherty, J.; Long, S.; D'Andrea, K.; Hamilton, J. T.; McLaughlin, M.; Williams, J. C.; Adamski, S.; The UPenn COVID Processing Unit, ; Kuthuru, O.; Frank, I.; Betts, M. R.; Vella, L. A.; Grifoni, A.; Weiskopf, D.; Set
10.1101/2021.08.23.457229 — immunology — Posted on 2021-08-23
1024 A multiscale spatiotemporal model explains succession in the early infant gut microbiota as a switch from aerobic to anaerobic metabolism
Versluis, D. M.; Schoemaker, R.; Looijesteijn, E.; Muysken, D.; Jeurink, P. V.; Paques, M.; Geurts, J. M. W.; Merks, R. M. H.
10.1101/2021.08.22.457032 — systems biology — Posted on 2021-08-23
1025 Pore structure controls stability and molecular flux in engineered protein cages
Adamson, L. S. R.; Tasneem, N.; Andreas, M. P.; Close, W.; Jenner, E. N.; Szyszka, T. N.; Young, R.; Cheah, L. C.; Norman, A.; MacDermott-Opeskin, H. I.; O'Mara, M. L.; Sainsbury, F.; Giessen, T. W.; Lau, Y. H.
10.1101/2021.01.27.428512 — synthetic biology — Posted on 2021-08-23
1029 Pseudoautosomal gene SHOX exhibits sex-biased random monoallelic expression and contributes to sex difference in height
Hattori, A.; Seki, A.; Inaba, N.; Nakabayashi, K.; Takeda, K.; Tatsusmi, K.; Naiki, Y.; Nakamura, A.; Ishiwata, K.; Matsumoto, K.; Nasu, M.; Okamura, K.; Michigami, T.; Katoh-Fukui, Y.; Umezawa, A.; Ogata, T.; Kagami, M.; Fukami, M.
10.1101/2021.08.23.457290 — genetics — Posted on 2021-08-23
1032 Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis
Singec, I.; Jovanovic, V.; Malley, C.; Tristan, C. A.; Ryu, S.; Chu, P.-H.; Barnaeva, E.; Ormanoglu, P.; Colon Mercada, J.; Michael, S.; Ward, M. E.; Simeonov, A.
10.1101/2021.08.23.457423 — developmental biology — Posted on 2021-08-23
1033 Presence and Stability of SARS-CoV-2 on Environmental Currency and Money Cards
Newey, C.; Olausson, A. T.; Applegate, A.; Reid, A. A.; Robison, R. A.; Grose, J. H.
10.1101/2021.08.23.457328 — microbiology — Posted on 2021-08-23
1036 Monodopsis and Vischeria genomes elucidate the biology of eustigmatophyte algae
Yang, H.-P.; Wenzel, M.; Hauser, D. A.; Nelson, J. M.; Xu, X.; Elias, M.; Li, F.-W.
10.1101/2021.08.22.457280 — genomics — Posted on 2021-08-23
1038 Forest growth responds more to air pollution than soil acidification
Hruska, J.; Oulehle, F.; Chuman, T.; Kolar, T.; Rybnicek, M.; McDowell, W. H.
10.1101/2021.08.23.457413 — ecology — Posted on 2021-08-23
1041 A robust ex vivo system to study cellular dynamics underlying mouse peri-implantation development
Ichikawa, T.; Zhang, H. T.; Panavaite, L.; Erzberger, A.; Fabreges, D.; Snajder, R.; Wolny, A.; Korotkevich, E.; Straeten, N. T.; Hufnagel, L.; Kreshuk, A.; Hiiragi, T.
10.1101/2021.08.22.457265 — developmental biology — Posted on 2021-08-23
1043 Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells.
Martini, V.; Edmans, M.; Gubbins, S.; Jayaraman, S.; Paudyal, B.; Morgan, S.; McNee, A.; Morin, T.; Rijal, P.; Gerner, W.; Sewell, A. K.; Inoue, R.; Bailey, M.; Connelley, T.; Charleston, B.; Townsend, A.; Beverley, P.; Tchilian, E.
10.1101/2021.08.23.457377 — immunology — Posted on 2021-08-23
1045 speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing
Di Roberto, R. B.; Castellanos-Rueda, R.; Schlatter, F. S.; Palianina, D.; Nguyen, O. T. P.; Kapetanovic, E.; Hierlemann, A.; Khanna, N.; Reddy, S. T.
10.1101/2021.08.23.457342 — synthetic biology — Posted on 2021-08-23
1046 An NLR Integrated Decoy toolkit to identify plant pathogen effector targets
Landry, D.; Mila, I.; Sabbagh, C. R. R.; Zaffuto, M.; Pouzet, C.; Trenousaygue, D.; Dabos, P.; Deslandes, L.; Peeters, N.
10.1101/2021.08.23.457316 — plant biology — Posted on 2021-08-23
1047 Induction of soluble platelet activation markers and FXIII deficiency promote COVID-19 severity
Al-Tamimi, A. O.; Yusuf, A. M.; Jayakumar, M. N.; Ansari, A. W.; Elhassan, M.; AbdulKarim, F.; Kannan, M.; Halwani, R.; Ahmad, F.
10.1101/2021.08.23.457378 — pathology — Posted on 2021-08-23
1048 Integrative Genome Modeling Platform reveals essentialityof rare contact events in 3D genome organizations
Boninsegna, L.; Yildirim, A.; Polles, G.; Quinodoz, S. A.; Finn, E. H.; Guttman, M.; Zhou, X. J.; Alber, F.
10.1101/2021.08.22.457288 — biophysics — Posted on 2021-08-23
1054 Insights from the genomes of four diploid Camelina spp.
Martin, S. L.; Toro, B. L.; James, T.; Sauder, C. A.; Laforest, M.
10.1101/2021.08.23.455123 — genomics — Posted on 2021-08-23
1058 Poly(A)-binding protein is an ataxin-2 chaperone that emulsifies biomolecular condensates.
Boeynaems, S.; Dorone, Y.; Marian, A.; Shabardina, V.; Huang, G.; Kim, G.; Sanyal, A.; Sen, N.-E.; Docampo, R.; Ruiz-Trillo, I.; Lasker, K.; Auburger, G.; Kabashi, E.; Gitler, A. D.
10.1101/2021.08.23.457426 — cell biology — Posted on 2021-08-23
1062 Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers.
Fasciano, A. C.; Dasanayake, G. S.; Estes, M. K.; Zachos, N. C.; Breault, D. T.; Isberg, R. R.; Tan, S.; Mecsas, J.
10.1101/2021.08.23.457340 — microbiology — Posted on 2021-08-23
1064 Temperature increase affects acetate-derived methane production in Alaskan lake sediments and wetland soils
Dellagnezze, B. M.; Winkler, P. B.; Lavergne, C.; Menoni, D. A.; Mosquillo, F.; Cabrol, L.; Barret, M.; Etchebehere, C.
10.1101/2021.08.22.457279 — microbiology — Posted on 2021-08-23
1065 Evolution of a putative, host-derived endosymbiont division ring and symbiosis-induced proteome rearrangements in the trypanosomatid Angomonas deanei
Morales, J.; Ehret, G.; Poschmann, G.; Reinicke, T.; Kroeninger, L.; Zanini, D.; Wolters, R.; Kalyanaraman, D.; Krakovka, M.; Stuehler, K.; Nowack, E. C. M.
10.1101/2021.08.23.457307 — microbiology — Posted on 2021-08-23
1066 c-di-AMP signaling is required for bile salts resistance and long-term colonization by Clostridioides difficile
Oberkampf, M.; Hamiot, A.; Altamirano-Silva, P.; Belles-sancho, P.; Tremblay, Y. D.; DiBenedetto, N.; Seifert, R.; SOUTOURINA, O.; Bry, L.; Dupuy, B.; PELTIER, J.
10.1101/2021.08.23.457418 — microbiology — Posted on 2021-08-23
1067 Coordinately regulated interbacterial antagonism defense pathways constitute a bacterial innate immune system
Ting, S.-Y.; LaCourse, K. D.; Ledvina, H. E.; Zhang, R.; Radey, M. C.; Kulasekara, H. D.; Somavanshi, R.; Bertolli, S. K.; Gallagher, L. A.; Kim, J.; Penewit, K. M.; Salipante, S. J.; Xu, L.; Peterson, S. B.; Mougous, J. D.
10.1101/2021.08.22.457286 — microbiology — Posted on 2021-08-23
1069 The crystal structure of the varicella zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity
Schweininger, J.; Kriegel, M.; Häge, S.; Conrad, M.; Alkhashrom, S.; Lösing, J.; Weiler, S.; Tillmanns, J.; Egerer-Sieber, C.; Decker, A.; Lenac Rovis, T.; Eichler, J.; Sticht, H.; Marschall, M.; Muller, Y.
10.1101/2021.08.23.457313 — biochemistry — Posted on 2021-08-23
1070 Switching of OAS1 splicing isoforms mitigates SARS-CoV-2 infection
Iida, K.; Ajiro, M.; Muramoto, Y.; Takenaga, T.; Denawa, M.; Kurosawa, R.; Noda, T.; Hagiwara, M.
10.1101/2021.08.23.457314 — genomics — Posted on 2021-08-23
1071 The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines
Liu, Y.; Arase, N.; Kishikawa, J.-i.; Hirose, M.; Li, S.; Tada, A.; Matsuoka, S.; Arakawa, A.; Akamatsu, K.; Ono, C.; Jin, H.; Kishida, K.; Nakai, W.; Kohyama, M.; Nakagawa, A.; Yamagishi, Y.; Nakagami, H.; Kumanogoh, A.; Matsuura, Y.; Standley, D. M.; Kato, T.; Okada, M.; Fujimoto, M.; Arase, H.
10.1101/2021.08.22.457114 — microbiology — Posted on 2021-08-23
1073 Deep Bayesian networks for uncertainty estimation and adversarial resistance of white matter hyperintensity segmentation
Mojiri Forooshani, P.; Biparva, M.; Ntiri, E. E.; Ramirez, J.; Boone, L.; Holmes, M. F.; Adamo, S.; Gao, F.; Ozzoude, M.; Scott, C. J. M.; Dowlatshahi, D.; Lawrence-Dewar, J. M.; Kwan, D.; Lang, A. E.; Marcotte, K.; Leonard, c.; Rochon, E.; Heyn, C.; Bartha, R.; Strother, S.; Tardif, J.-C.; Symons, S.; Masellis, M.; Swartz, R. H.; Moody, A.; Black, S. E.; Goubran, M.
10.1101/2021.08.18.456666 — neuroscience — Posted on 2021-08-23
1074 Anxiety-related frontocortical activity is associated with dampened stressor reactivity in the real world
Hur, J.; Kuhn, M.; Grogans, S. E.; Anderson, A. S.; Islam, S.; Kim, H. C.; Tillman, R. M.; Fox, A. S.; Smith, J. F.; DeYoung, K. A.; Shackman, A. J.
10.1101/2021.03.17.435791 — neuroscience — Posted on 2021-08-23
1075 White matter myelination during early infancy is explained by spatial gradients and myelin content at birth
Grotheer, M.; Rosenke, M.; Wu, H.; Kular, H.; Querdasi, F. R.; Natu, V.; Yeatman, J. D.; Grill-spector, K.
10.1101/2021.03.29.437583 — neuroscience — Posted on 2021-08-23
1076 High Dimensionality Reduction by Matrix Factorization for Systems Pharmacology
Mehrpooya, A.; Saberi-Movahed, F.; Azizizadeh, N.; Rezaei-Ravari, M.; Saberi-Movahed, F.; Eftekhari, M.; Tavassoly, I.
10.1101/2021.05.30.446301 — systems biology — Posted on 2021-08-23
1077 3D reconstruction identifies loci linked to variation in angle of individual sorghum leaves
Tross, M. C.; Gaillard, M.; Zwiener, M.; Miao, C.; Grove, R. J.; Li, B.; Benes, B.; Schnable, J. C.
10.1101/2021.06.15.448566 — plant biology — Posted on 2021-08-23
1082 Global prevalence of potentially pathogenic short-tandem repeats in an epilepsy cohort
Moreau, C.; Michaud, J. L.; Hamdan, F. F.; Bouchard, J.; Tremblay, V.; Minassian, B. A.; Cossette, P.; Girard, S. L.
10.1101/2020.08.20.259168 — genetics — Posted on 2021-08-23
1084 Ancestral protein topologies draw the rooted bacterial tree of life
Dimas-Torres, J.-U.; Rodriguez-Hernandez, A.; Valencia-Sanchez, M.-I.; Campos-Chavez, E.; Godinez-Lopez, V.; Rodriguez-Chamorro, D.-E.; Grotli, M.; Fleming, C.; Hernandez-Gonzalez, A.; Arciniega, M.; Torres-Larios, A.
10.1101/2021.08.20.456953 — evolutionary biology — Posted on 2021-08-23
1085 Ethology of morphogenesis reveals the design principles of cnidarian size and shape development
Stokkermans, A.; Chakrabarti, A.; Wang, L.; Moghe, P.; Subramanian, K.; Steenbergen, P.; Moenke, G.; Hiiragi, T.; Prevedel, R.; Mahadevan, L.; Ikmi, A.
10.1101/2021.08.19.456976 — developmental biology — Posted on 2021-08-23
1086 GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence
van Asperen, J. V.; Uceda-Castro, R.; Vennin, C.; Sluijs, J.; van Bodegraven, E. J.; Margarido, A. S.; Robe, P.; van Rheenen, J.; Hol, E. M.
10.1101/2021.08.19.456978 — cell biology — Posted on 2021-08-23
1087 LAP1 regulates nuclear plasticity to enable constrained migration
Jung-Garcia, Y.; Maiques, O.; Rodriguez-Hernandez, I.; Fanshawe, B.; Domart, M.-C.; Renshaw, M. J.; Marti, R. M.; Matias-Guiu, X.; Collinson, L.; Sanz-Moreno, V.; Carlton, J. G.
10.1101/2021.06.23.449503 — cell biology — Posted on 2021-08-23
1089 Generation of chimeric respiratory viruses with altered tropism by coinfection of influenza A virus and respiratory syncytial virus
Haney, J.; Vijayakrishnan, S.; Streetley, J.; Dee, K.; Goldfarb, D.; Clarke, M.; Mullin, M.; Carter, S. D.; Bhella, D.; Murcia, P. R.
10.1101/2021.08.16.456460 — microbiology — Posted on 2021-08-23
1091 Shallow Unsupervised Models Best Predict Neural Responses in Mouse Visual Cortex
Nayebi, A.; Kong, N. C. L.; Zhuang, C.; Gardner, J. L.; Norcia, A. M.; Yamins, D. L. K.
10.1101/2021.06.16.448730 — neuroscience — Posted on 2021-08-23
1093 ACTION AFFORDANCE AFFECTS PROXIMAL AND DISTAL GOAL-ORIENTED PLANNING
Keshava, A.; Gottschewsky, N.; Balle, S.; Nezami, F. N.; Schueler, T.; Koenig, P.
10.1101/2021.07.27.454022 — neuroscience — Posted on 2021-08-23
1095 Metamodal Coupling of Vibrotactile and Auditory Speech Processing Systems Through Matched Stimulus Representations
Damera, S. R.; Malone, P.; Stevens, B.; Klein, R.; Eberhardt, S. P.; Auer, E. T.; Bernstein, L. E.; Riesenhuber, M.
10.1101/2021.05.04.442660 — neuroscience — Posted on 2021-08-23
1100 Using historical museum samples to examine divergent and parallel evolution in the invasive starling
Stuart, K. C.; Sherwin, W. B.; Austin, J. J.; Bateson, M.; Eens, M.; Brandley, M. C.; Rollins, L. A.
10.1101/2021.08.22.457241 — evolutionary biology — Posted on 2021-08-23
1102 Centriole-independent centrosome assembly in interphase mammalian cells
Chen, F.; Wu, J.; Iwanski, M. K.; Jurriens, D.; Sandron, A.; Pasolli, M.; Puma, G.; Kromhout, J. Z.; Yang, C.; Nijenhuis, W.; Kapitein, L. C.; Akhmanova, A.
10.1101/2021.08.22.457259 — cell biology — Posted on 2021-08-23
1107 RNA-Seq is not required to determine stable reference genes for qPCR normalization
Sampathkumar, N. K.; Sundaram, V. K.; Danthi, P. S.; Barakat, R.; Solomon, S.; Mondal, M.; Carre, I.; El Jalkh, T.; Padilla-Ferrer, A.; Grenier, J.; Massaad, C.; Mitchell, J. C.
10.1101/2021.08.21.457202 — molecular biology — Posted on 2021-08-23
1108 Patient-Derived Three-Dimensional Cortical Neurospheres to Model Parkinson's Disease
Raja, W. K.; Neves, E.; Burke, C.; Jiang, X.; Xu, P.; Rhodes, K. J.; Khurana, V.; Scannevin, R. H.; Chung, C. Y.
10.1101/2021.08.21.457201 — neuroscience — Posted on 2021-08-23
1110 Electrical activity recorded from the spinal cord in freely moving rats using a subdural bioelectronic implant
Harland, B. C.; Aqrawe, Z.; Vomero, M.; Boehler, C.; Raos, B.; Asplund, M.; O'Carroll, S.; Svirskis, D.
10.1101/2021.08.21.457239 — bioengineering — Posted on 2021-08-23
1112 Interspecific interactions regulate plant reproductive allometry in cereal-legume intercropping systems
Gaudio, N.; Violle, C.; Gendre, X.; Fort, F.; Mahmoud, R.; Pelzer, E.; Mediene, S.; Hauggaard-Nielsen, H.; Bedoussac, L.; Bonnet, C.; Corre-Hellou, G.; Couëdel, A.; Hinsinger, P.; Steen Jensen, E.; Journet, E.-P.; Justes, E.; Kammoun, B.; Litrico, I.; Moutier, N.; Naudin, C.; Casadebaig, P.
10.1101/2021.06.17.448782 — ecology — Posted on 2021-08-23
1118 Major orchestration of shikimate, early phenylpropanoid and stilbenoid pathways by Subgroup 2 R2R3-MYBs in grapevine
Orduna, L.; Li, M.; Navarro-Paya, D.; Zhang, C.; Santiago, A.; Romero, P.; Ramsak, Z.; Magon, G.; Höll, J.; Merz, P.; Gruden, K.; Vannozzi, A.; Cantu, D.; Bogs, J.; Wong, D. C. J.; Huang, S.-s. C.; Matus, J. T.
10.1101/2020.12.31.424746 — plant biology — Posted on 2021-08-23
1120 Loops, TADs, Compartments, and Territories are Elastic and Robust to Dramatic Nuclear Volume Swelling
Sanders, J. T.; Golloshi, R.; Terry, P. H.; Nash, D. G.; Xu, Y.; Dekker, J.; McCord, R. P.
10.1101/2021.08.20.457153 — genomics — Posted on 2021-08-23
1121 TemplateFlow: FAIR-sharing of multi-scale, multi-species brain models
Ciric, R.; Thompson, W. H.; Lorenz, R.; Goncalves, M.; MacNicol, E.; Markiewicz, C.; Halchenko, Y.; Ghosh, S. S.; Gorgolewski, K. J.; Poldrack, R.; Esteban, O.
10.1101/2021.02.10.430678 — neuroscience — Posted on 2021-08-23
1122 Resting Parasympathetic Nervous System Activity is Associated with Greater Antiviral Gene Expression
Rahal, D.; Tashjian, S. M.; Karan, M.; Eisenberger, N.; Galvan, A.; Fuligni, A. J.; Cole, S. W.
10.1101/2021.08.21.457209 — physiology — Posted on 2021-08-23
1124 Socially stratified epigenetic profiles are associated with cognitive functioning in children and adolescents
Raffington, L. A. S.; Tanksley, P.; Sabhlok, A.; Vinnik, L.; Mallard, T. T.; King, L.; Goosby, B.; Harden, K. P.; Tucker-Drob, E. M.
10.1101/2021.08.19.456979 — genetics — Posted on 2021-08-23
1125 Characterization of a vaccine-elicited human antibody with sequence homology to VRC01-class antibodies that binds the C1C2 gp120 domain
Gray, M. D.; Feng, J.; Weidle, C. E.; Cohen, K. W.; Ballweber-Fleming, L.; MacCamy, A. J.; Huynh, C. N.; Trichka, J. J.; Montefiori, D.; Ferrari, G.; Pancera, M.; McElrath, M. J.; Stamatatos, L.
10.1101/2021.08.21.457217 — immunology — Posted on 2021-08-23
1127 Online self-evaluation of fMRI-based neurofeedback performance
Munoz-Moldes, S.; Tursic, A.; Lührs, M.; Eck, J.; Benitez Andonegui, A.; Peters, J.; Cleeremans, A.; Goebel, R.
10.1101/2021.08.20.457108 — neuroscience — Posted on 2021-08-23
1129 An inexpensive setup for robust activity tracking in small animals: Portable Locomotion Activity Monitor (pLAM)
Sondhi, Y.; Jo, N. J.; Alpizar, B.; Markee, A.; Dansby, H. E.; Currea, J. P.; Ruiz, C.; Fabian, S. T.; Barredo, E.; Degennaro, M.; Kawahara, A. Y.; Theobald, J. C.
10.1101/2021.08.21.457197 — animal behavior and cognition — Posted on 2021-08-23
1132 Modeling miRNA-driven post-transcriptional regulatory signals by using exon-intron split analysis (EISA) in pigs
Marmol-Sanchez, E.; Cirera, S.; Zingaretti, L.; Jacobsen, M. J.; Ramayo-Caldas, Y.; Jorgensen, C. B.; Fredholm, M.; Cardoso, T. F.; Quintanilla, R.; Amills, M.
10.1101/2021.07.14.452370 — genomics — Posted on 2021-08-23
1133 Tripartite networks show that keystone species can multitask
Timoteo, S.; Albrecht, J.; Rumeu, B.; Norte, A. C.; Traveset, A.; Frost, C.; Marchante, E.; Lopez-Nunez, F. A.; Peralta, G.; Memmott, J.; Olesen, J.; Costa, J. M.; da Silva, L. P.; Carvalheiro, L. G.; Correia, M.; Staab, M.; Blüthgen, N.; Farwig, N.; Mironov, S.; Rodriguez-Echeverria, S.; Heleno, R.
10.1101/2021.04.01.437523 — ecology — Posted on 2021-08-23
1134 Landscape connectivity alters the evolution of density-dependent dispersal during pushed range expansions
Dahirel, M.; Bertin, A.; Calcagno, V.; Duraj, C.; Fellous, S.; Groussier, G.; Lombaert, E.; Mailleret, L.; Marchand, A.; Vercken, E.
10.1101/2021.03.03.433752 — ecology — Posted on 2021-08-23
1136 Robustness in spiking networks: a geometric perspective
Calaim, N.; Dehmelt, F. A.; Goncalves, P. J.; Machens, C. K.
10.1101/2020.06.15.148338 — neuroscience — Posted on 2021-08-23
1138 Model sharing in the human medial temporal lobe
Glitz, L.; Juechems, K.; Summerfield, C.; Garrett, N.
10.1101/2021.06.23.449588 — neuroscience — Posted on 2021-08-23
1139 BIFURCATING NEURONS IN THE ANTERIOR THALAMIC NUCLEI
Pei, Y.; Tasananukorn, S.; Wolff, M.; Dalrymple-Alford, J. C.
10.1101/2021.08.21.457238 — neuroscience — Posted on 2021-08-23
1140 Temporal Perturbations Cause Global Sensorimotor Adaptation
Schlichting, N.; Kartashova, T.; Wiesing, M.; Zimmermann, E.
10.1101/2021.03.31.437803 — neuroscience — Posted on 2021-08-23
1141 Does time matter in phylogeny? A perspective from the fossil record
Guenser, P.; Warnock, R. C. M.; Pett, W.; Donoghue, P. C. J.; Jarochowska, E.
10.1101/2021.06.11.445746 — paleontology — Posted on 2021-08-23
1142 C/EBPB-dependent Adaptation to Palmitic Acid Promotes Stemness in Hormone Receptor Negative Breast Cancer
Liu, X.; Rulina, A.; Choi, M. H.; Pedersen, L.; Lepland, J.; Takle, S.; Madeleine, N.; Peters, S.; Wogsland, C. E.; Grondal, S. M.; Lorens, J.; Goodarzi, H.; Molven, A.; Lonning, P. E.; Knappskog, S.; Halberg, N.
10.1101/2020.08.11.244509 — cancer biology — Posted on 2021-08-23
1147 TWIST1 interacts with adherens junction proteins during neural tube formation and regulates fate transition in cranial neural crest cells
Bertol, J. W.; Johnston, S.; Ahmed, R.; Xie, V. K.; Cruz, L.; Nitschke, L.; Stetsiv, M.; Goering, J. P.; Nistor, P.; Lowell, S.; Hoskens, H.; Claes, P.; Weinberg, S. M.; Saadi, I.; Farach-Carson, M. C.; Fakhouri, W. D.
10.1101/2021.08.22.457283 — developmental biology — Posted on 2021-08-22
1155 Stability Comparisons between Natural versus Engineered Archaeal Heat Shock Proteins
Furr, M. M.; Basha, S.; Agrawal, S.; Alraawi, Z.; Ghosh, P.; Stacy, C. L.; Suresh Kumar, T. K.; Ceballos, R. M.
10.1101/2021.08.21.457208 — biochemistry — Posted on 2021-08-22
1157 Recovery of high quality metagenome-assembled genomes from full-scale activated sludge microbial communities in a tropical climate using longitudinal metagenome sampling
Haryono, M. A. S.; Law, Y.; Arumugam, K.; Liew, L. C. W.; Nguyen, A. T. Q. N.; Drautz-Moses, D. I.; Schuster, S. C.; Wuertz, S.; Williams, R. B. H.
10.1101/2021.08.21.456929 — genomics — Posted on 2021-08-22
1159 Diversification of small RNA pathways underlies germline RNAi incompetence in wild C. elegans strains
Chou, H. T.; Valencia, F.; Alexander, J. C.; Bell, A. D.; Deb, D.; Pollard, D. A.; Paaby, A. B.
10.1101/2021.08.21.457212 — evolutionary biology — Posted on 2021-08-22
1160 Distant water industrial fishing in developing countries: A case study of Madagascar
White, E. R.; Baker-Medard, M.; Vakhitova, V. K.; Farquhar, S.; Ramaharitra, T. T.
10.1101/2021.05.13.444019 — ecology — Posted on 2021-08-22
1161 Acquisition of cell identity in the brown alga Ectocarpus: which of time, cell shape or position matters most?
Billoud, B.; Saint-Marcoux, D.; Chenivesse, S.; Duchene, C.; Nous, C.; Langdale, J. A.; Charrier, B.
10.1101/2021.08.21.457218 — developmental biology — Posted on 2021-08-22
1164 Rab11 endosomes coordinate centrosome number and movement following mitotic exit
Krishnan, N.; Swoger, M.; Bates, M.; Freshour, J.; Fioramonti, P.; Patteson, A. E.; Hehnly, H.
10.1101/2021.08.11.455966 — cell biology — Posted on 2021-08-22
1166 A standard knockout procedure alters expression of adjacent loci at the translational level
Egorov, A. A.; Alexandrov, A. I.; Urakov, V. N.; Makeeva, D. S.; Edakin, R. O.; Kushchenko, A. S.; Gladyshev, V. N.; Kulakovskiy, I. V.; Dmitriev, S. E.
10.1101/2021.08.21.457210 — molecular biology — Posted on 2021-08-22
1170 Active anaerobic methane oxidation and sulfur disproportionation in the deep terrestrial subsurface
Bell, E.; Lamminmaki, T.; Alneberg, J.; Qian, C.; Xiong, W.; Hettich, R. L.; Frutschi, M.; Bernier-Latmani, R.
10.1101/2021.08.21.457207 — microbiology — Posted on 2021-08-22
1172 Genotype-specific Features Reduce the Susceptibility of South American Yellow Fever Virus Strains to Vaccine-Induced Antibodies
Haslwanter, D.; Lasso, G.; Wec, A. Z.; Furtado, N. D.; Raphael, L. M. S.; Sun, Y.; Stransky, S.; Pedreno-Lopez, N.; Tse, A.; Correia, C. A.; Bornholdt, Z. A.; Sakharkar, M.; Avelino-Silva, V. I.; Moyer, C. L.; Watkins, D. I.; Kallas, E. G.; Sidoli, S.; Walker, L. M.; Bonaldo, M. C.; Chandran, K.
10.1101/2021.08.22.457235 — microbiology — Posted on 2021-08-22
1174 Pro-IL-18 secreted by keratinocytes detects the group A streptococcal protease SpeB
Johnson, A. F.; Sands, J. S.; Trivedi, K.; Russell, R.; LaRock, D. L.; LaRock, C. N.
10.1101/2021.08.22.457234 — microbiology — Posted on 2021-08-22
1175 Bantam regulates the adult sleep circuit in Drosophila
Hobin, M.; Dorfman, K.; Adel, M.; Rivera-Rodriguez, E. J.; Griffith, L. C.
10.1101/2021.08.21.457226 — neuroscience — Posted on 2021-08-22
1176 BIFURCATING NEURONS IN THE ANTERIOR THALAMIC NUCLEI
Pei, Y.; Tasananukorn, S.; Wolff, M.; Dalrymple-Alford, J. C.
10.1101/2021.08.21.457238 — neuroscience — Posted on 2021-08-22
1178 Eliminating Aedes aegypti from its southern margin in Australia: insights from genomic data and simulation modeling
Rasic, G.; Filipovic, I.; Wu, S. L.; Leon, T. M.; Bennett, J. B.; Sanchez Castellanos, H. M.; Marshall, J. M.; Trewin, B.
10.1101/2021.08.21.457232 — systems biology — Posted on 2021-08-22
1179 A deep mutational scanning platform to characterize the fitness landscape of anti-CRISPR proteins
Stadelmann, T.; Heid, D.; Jendrusch, M.; Mathony, J. P.; Rosset, S.; Correia, B.; Niopek, D.
10.1101/2021.08.21.457204 — synthetic biology — Posted on 2021-08-22
1181 MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer
Prasad, M.; Zorea, J.; Jagadeeshan, S.; Shnerb, A.; Bouaoud, J.; Michon, L.; Novoplansky, O.; Badarni, M.; Cohen, L.; Yagodayev, K.; Tzadok, S.; Rotblat, B.; Brezina, L.; Mock, A.; Karabajakian, A.; Fayette, J.; Cohen, I.; Cooks, T.; Allon, I.; Dimitstei, O.; Joshua, B.; Kong, D.; Voronov, E.; Scaltriti, M.; Carmi, Y.; Hess, J.; Morris, L. G. T.; Saintigny, P.; Elkabets, M.
10.1101/2021.08.22.457244 — cancer biology — Posted on 2021-08-22
1183 Mechanistic basis for the emergence of EPS1 as a catalyst in plant salicylic acid biosynthesis
Torrens-Spence, M. P.; Li, T.; Wang, Z.; Glinkerman, C. M.; Matos, J. O.; Wang, Y.; Weng, J.-K.
10.1101/2021.08.21.457228 — biochemistry — Posted on 2021-08-22
1185 Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular S. Typhimurium
Cohen, H.; Hoede, C.; Scharte, F.; Coluzzi, C.; Cohen, E.; Shomer, I.; Mallet, L.; Serre, R. F.; Schiex, T.; Virlogeux-Payant, I.; Grassl, G.; Hensel, M.; Chiapello, H.; Gal-Mor, O.
10.1101/2021.08.18.456644 — microbiology — Posted on 2021-08-22
1186 Loss of SORCS2 is associated with neuronal DNA double-strand breaks
Gospodinova, K. O.; Olsen, D.; Kaas, M.; Anderson, S. M.; Phillips, J. L.; Walker, R.; Bermingham, M. L.; Payne, A. L.; Giannopoulos, P.; Pandya, D.; Spires-Jones, T.; Abbott, C. M.; Porteous, D.; Glerup, S.; Evans, K. L.
10.1101/2021.04.28.441600 — neuroscience — Posted on 2021-08-22
1187 Nanomechanics combined with HDX reveal allosteric drug binding sites of CFTR NBD1
Padanyi, R.; Farkas, B.; Tordai, H.; Kiss, B.; Grubmuller, H.; Soya, N.; Lukacs, G.; Kellermayer, M.; Hegedus, T.
10.1101/2021.08.20.457065 — biophysics — Posted on 2021-08-22
1188 Structural basis for the specificity of PPM1H phosphatase for Rab GTPases
Waschbüsch, D.; Berndsen, K.; Lis, P.; Knebel, A.; Lam, Y. P.; Alessi, D. R.; Khan, A. R.
10.1101/2021.02.17.431620 — biochemistry — Posted on 2021-08-22
1189 Zebrafish heme oxygenase 1a is necessary for normal development and macrophage migration
Luo, K.; Ogawa, M.; Ayer, A.; Britton, W. J.; Stocker, R.; Kikuchi, K.; Oehlers, S. H.
10.1101/2021.04.07.438802 — developmental biology — Posted on 2021-08-22
1190 Systems-wide Analysis Revealed Shared and Unique Responses to Moderate and Acute High Temperatures in the Green Alga Chlamydomonas reinhardtii
Zhang, N.; Mattoon, E. M.; McHargue, W.; Venn, B.; Zimmer, D.; Pecani, K.; Jeong, J.; Anderson, C. M.; Chen, C.; Berry, J. C.; Xia, M.; Tzeng, S.-C.; Becker, E.; Pazouki, L.; Evans, B.; Cross, F.; Cheng, J.; Czymmek, K. J.; Schroda, M.; Muhlhaus, T.; Zhang, R.
10.1101/2021.08.17.456552 — plant biology — Posted on 2021-08-22
1196 Age-related changes in Tau and Autophagy in human brain in the absence of neurodegeneration
Mudher, A.; Chatterjee, S.; Sealey, M.; Ruiz, E.; Pegasiou, C. M.; Green, S.; Crisford, A.; Vasquez, M. D.; Luckett, E.; Robertson, R.; Richardson, P.; Vajramani, G.; Grundy, P.; Bulters, D.; Proud, C.; Vargas-Caballero, M.
10.1101/2021.08.21.456385 — neuroscience — Posted on 2021-08-21
1199 Bioequivalence Assessment of High-Capacity Polymeric Micelle Nanoformulation of Paclitaxel and Abraxane(R) in Rodent and Non-Human Primate Models Using a Stable Isotope Tracer Assay
Hwang, D.; Vinod, N.; Skoczen, S. L.; Ramsey, J. D.; Snapp, K. S.; Montgomery, S. A.; Wang, M.; Lim, C.; Frank, J. E.; Sokolsky-Papkov, M.; Li, Z.; Yuan, H.; Stern, S. T.; Kabanov, A. V.
10.1101/2021.08.20.457164 — pharmacology and toxicology — Posted on 2021-08-21
1203 Engineering large-scale perfused tissues via synthetic 3D soft microfluidics
Grebeniuk, S.; Abdel Fattah, A. R.; Rustandi, G.; Kumar, M.; Toprakhisar, B.; Salmon, I.; Verfaillie, C.; Ranga, A.
10.1101/2021.08.20.457148 — bioengineering — Posted on 2021-08-21
1204 Liver enhancer signature and regulatory network of non-alcoholic steatohepatitis resistance in humans with obesity
Hung, Y.-H.; Sritharan, R.; Vohl, M.-C.; Ilkayeva, O.; Biertho, L.; Tchernof, A.; White, P.; Sethupathy, P.
10.1101/2021.08.20.457162 — genomics — Posted on 2021-08-21
1205 Physiological and genetic drivers underpinning canopy development are associated with durum wheat yield in rainfed environments
Kang, Y.; Haeften, S. V.; Bustos-Korts, D.; Vukasovic, S.; Khan, S. U.; Christopher, J.; Chenu, K.; Able, J. A.; Smith, M. R.; Voss-Fels, K. P.; Potgieter, A. B.; Jordan, D. R.; Borrell, A. K.; Alahmad, S.; Hickey, L. T.
10.1101/2021.08.21.457180 — genetics — Posted on 2021-08-21
1206 Chromosomal rearrangements preserve adaptive divergence in ecological speciation
Jackson, C. E.; Xu, S.; Ye, Z.; Pfrender, M. E.; Lynch, M.; Colbourne, J. K.; Shaw, J. R.
10.1101/2021.08.20.457158 — evolutionary biology — Posted on 2021-08-21
1207 Evidence of long-term purging of mutation load in killer whale genomes
Foote, A. D.; Gilbert, T. P.; Gopalakrishnan, S.; Louis, M.; Martin, M.; Morin, P. A.; Nykanen, M.; Scharff-Olsen, C.; Excoffier, L. A.
10.1101/2021.08.21.457186 — evolutionary biology — Posted on 2021-08-21
1209 Ecological dynamics of the gut microbiome in response to dietary fiber
Liu, H.; Liao, C.; Tang, J.; Chen, J.; Lei, C.; Zheng, L.; Wu, L.; Zhang, C.; Liu, Y.-Y.; Xavier, J.; Dai, L.
10.1101/2021.08.20.457175 — ecology — Posted on 2021-08-21
1212 Identification and targeting of a pan-genotypic influenza A virus RNA structure that mediates packaging and disease.
Hagey, R. J.; Elazar, M.; Tian, S.; Pham, E. A.; Kladwang, W.; Ben-Avi, L.; Nguyen, K.; Xiong, A.; Rabinovich, M.; Schaffert, S.; Avisar, T.; Fram, B.; Liu, P.; Khatri, P.; Taubenberger, J. K.; Das, R.; Glenn, J. S.
10.1101/2021.08.21.457170 — microbiology — Posted on 2021-08-21
1213 A small molecule drug screening identifies colistin sulfate as an enhancer of Natural Killer cell cytotoxicity.
Cortes-Kaplan, S.; Hasim, M.; Kaczmarek, S.; Taha, Z.; Maznyi, G.; McComb, S.; Lee, S.-H.; Diallo, J.-S.; Ardolino, M.
10.1101/2021.08.20.457155 — immunology — Posted on 2021-08-21
1215 TRPA1 is a source of calcium-mediated cardiac mechano-arrhythmogenesis
Cameron, B. A.; Stoyek, M. R.; Bak, J. J.; Connolly, M. S.; Greiner, J.; Peyronnet, R.; Kohl, P.; Quinn, T. A.
10.1101/2020.10.01.321638 — physiology — Posted on 2021-08-21
1217 The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2
Kerk, S. A.; Lin, L.; Myers, A. L.; Zhang, Y.; Jimenez, J. A.; Sajjakulnukit, P.; Nelson, B. S.; Chen, B.; Robinson, A.; Thurston, G.; Kemp, S. B.; Steele, N. G.; Hoffman, M. T.; Wen, H.-J.; Long, D.; Ackenhusen, S. E.; Ramos, J.; Gao, X.; Zhang, L.; Andren, A.; Nwosu, Z. C.; Galban, S.; Halbrook, C. J.; Lombard, D. B.; Piwnica-Worms, D. R.; Ying, H.; Crawford, H. C.; Pasca di Magliano, M.; Shah, Y. M.; Lyssiotis, C. A.
10.1101/2020.08.07.238766 — cancer biology — Posted on 2021-08-21
1228 OsSWEET11b, a sixth leaf blight susceptibility gene involved in sugar transport-dependent male fertility
Wu, L.-B.; Eom, J.-S.; Isoda, R.; Li, C.; Char, S. N.; Luo, D.; Luu, V. T.; Nakamura, M.; Yang, B.; Frommer, W. B.
10.1101/2021.08.21.457078 — plant biology — Posted on 2021-08-21
1231 Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis
Xia, F.; Ma, Y.; Chen, K.; Duong, B.; Ahmed, S.; Atwal, R.; Philpott, D.; Ketela, T.; Pantea, J.; Lin, S.; Angers, S.; Kelley, S.
10.1101/2021.08.20.457126 — cancer biology — Posted on 2021-08-21
1232 Integration of whole genome sequencing and transcriptomics reveals a complex picture of insecticide resistance in the major malaria vector Anopheles coluzzii
Ingham, V. A.; Tennessen, J. A.; Lucas, E. R.; Elg, S.; Carrington-Yates, H.; Carson, J.; Guelbeogo, W. M.; Sagnon, N.; Hughes, G.; Heinz, E.; Neafsey, D. E.; Ranson, H.
10.1101/2021.08.21.457189 — genomics — Posted on 2021-08-21
1235 Disruption of Brachypodium Lichenase Alters Metabolism of Mixed-linkage Glucan and Starch
Fan, M.; Jensen, J. K.; Zemelis-Durfee, S.; Kim, S.-J.; Chan, J.-Y.; Beaudry, C. M.; Brandizzi, F.; Wilkerson, C. G.
10.1101/2021.08.20.457123 — plant biology — Posted on 2021-08-21
1236 Evidence of long-term purging of mutation load in killer whale genomes
Foote, A. D.; Gilbert, T. P.; Gopalakrishnan, S.; Louis, M.; Martin, M.; Morin, P. A.; Nykanen, M.; Scharff-Olsen, C.; Excoffier, L. A.
10.1101/2021.08.21.457186 — evolutionary biology — Posted on 2021-08-21
1237 Epigenetic MRI: Noninvasive Imaging of DNA Methylation in the Brain
Lam, F.; Chu, J.; Choi, J. S.; Cao, C.; Hitchens, T. K.; Silverman, S. K.; Liang, Z.-P.; Dilger, R. N.; Robinson, G. E.; Li, K. C.
10.1101/2021.08.20.457113 — bioengineering — Posted on 2021-08-21
1239 Bidirectional synaptic plasticity rapidly modifies hippocampal representations
Milstein, A. D.; Li, Y.; Bittner, K. C.; Grienberger, C.; Soltesz, I.; Magee, J. C.; Romani, S.
10.1101/2020.02.04.934182 — neuroscience — Posted on 2021-08-21
1244 Mg2+-dependent conformational equilibria in CorA: an integrated view on transport regulation
Johansen, N. T.; Bonaccorsi, M.; Bengtsen, T.; Larsen, A. H.; Tidemand, F. G.; Pedersen, M. C.; Huda, P.; Berndtsson, J.; Darwish, T.; Yepuri, N. R.; Martel, A.; Pomorski, T.; Bertarello, A.; Sansom, M. S.; Rapp, M.; Crehuet, R.; Schubeis, T.; Lindorff-Larsen, K.; Pintacuda, G.; Arleth, L.
10.1101/2021.08.20.457080 — biophysics — Posted on 2021-08-21
1247 Cannabidiol activates neuronal Kv7 channels
Niday, Z.; Heckman, L.; Jo, S.; Zhang, H.-X. B.; Fujita, A.; Shim, J.; Pandey, R.; Al Jandal, H.; Jayakar, S.; Smith, J. A.; Woolf, C. J.; Bean, B. P.
10.1101/2021.08.20.457154 — neuroscience — Posted on 2021-08-21
1249 Liquid-liquid phase separation of florigen activation complex induces flowering
Taoka, K.-i.; Tsuji, H.; Anzawa, S.; Enomoto, M.; Koizumi, Y.; Nakamura, J.; Tanaka, M.; Fujita, A.; Furuita, K.; Kodama, T. S.; Fujimoto, M.; Kurokawa, K.; Okamoto, T.; Fujiwara, T.; Nakano, A.; Kojima, C.
10.1101/2021.08.19.456992 — plant biology — Posted on 2021-08-21
1251 A population-level invasion by transposable elements triggers genome expansion in a fungal pathogen
Oggenfuss, U.; Badet, T.; Wicker, T.; Hartmann, F. E.; Kumar Singh, N.; Abraham, L. N.; Karisto, P.; Vonlanthen, T.; Mundt, C. C.; McDonald, B. A.; Croll, D.
10.1101/2020.02.11.944652 — genomics — Posted on 2021-08-20
1255 Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
Sadeghi, I.; Gispert, J. D.; Palumbo, E.; Munoz-Aguirre, M.; Wucher, V.; D'Argenio, V.; Santpere, G.; Navarro, A.; Guigo, R.; Vilor-Tejedor, N.
10.1101/2021.08.16.456345 — neuroscience — Posted on 2021-08-20
1257 A State Space Modeling Approach to Real-Time Phase Estimation
Wodeyar, A.; Schatza, M.; Widge, A. S.; Eden, U. T.; Kramer, M. A.
10.1101/2021.03.25.437024 — neuroscience — Posted on 2021-08-20
1259 B1L regulates lateral root development by exocytic vesicular trafficking-mediated polar auxin transport
Gang, Y.; Bi-xia, C.; Tao, C.; Jia-hui, C.; Rui, S.; Cong-cong, L.; Jiao, J.; Xiu-le, Y.; Lizhe, A.; Hua, Z.
10.1101/2021.06.07.447418 — plant biology — Posted on 2021-08-20
1260 Immunosuppressive traits of the hybrid epithelial/mesenchymal phenotype
Sahoo, S.; Nayak, S. P.; Hari, K.; Purkait, P.; Mandal, S.; Kishore, A.; Levine, H.; Jolly, M. K.
10.1101/2021.06.21.449285 — cancer biology — Posted on 2021-08-20
1261 Transcriptional Control of Brain Tumour Stem Cell by a Carbohydrate Binding Protein
Sharanek, A.; Burban, A.; Hernandez-Corchado, A.; Madrigal, A.; Fatakdawala, I.; Najafabadi, H. S.; Soleimani, V. D.; Jahani-Asl, A.
10.1101/2021.04.14.439704 — cancer biology — Posted on 2021-08-20
1262 Anatomic position determines oncogenic specificity in melanoma
Weiss, J. M.; Hunter, M. V.; Cruz, N. M.; Baggiolini, A.; Tagore, M.; Ma, Y.; Misale, S.; Marasco, M.; Simon-Vermot, T.; Campbell, N. R.; Newell, F.; Wilmott, J. S.; Johansson, P. A.; Thompson, J. F.; Long, G. V.; Pearson, J. V.; Mann, G. J.; Scolyer, R. A.; Waddell, N.; Montal, E. D.; Huang, T.-H.; Jonsson, P.; Donoghue, M. T. A.; Harris, C. C.; Taylor, B. S.; Xu, T.; Chaligne, R.; Shliaha, P.; Hendrickson, R.; Jungbluth, A. A.; Lezcano, C.; Koche, R.; Studer, L.; Ariyan, C. E.; Solit, D. B.; Wolchok, J. D.; Merghoub, T.; Rosen, N.; Hayward, N. K.; White, R. M.
10.1101/2020.11.14.383083 — cancer biology — Posted on 2021-08-20
1263 Benchmarking PSM identification tools for single cell proteomics
Van Der Watt, D.; Boekweg, H.; Truong, T.; Guise, A. J.; Plowey, E. D.; Kelly, R. T.; Payne, S. H.
10.1101/2021.08.17.456676 — bioinformatics — Posted on 2021-08-20
1265 A dual allosteric pathway drives human mitochondrial Lon
Valentin Gese, G.; Shahzad, S.; Pardo-Hernandez, C.; Wramstedt, A.; Falkenberg, M.; Hällberg, B. M.
10.1101/2021.06.09.447696 — biochemistry — Posted on 2021-08-20
1267 wnt16 exerts pleiotropic effects on bone and lean mass in zebrafish
Watson, C. J.; Morfin Montes de Oca, E.; Fiedler, I. A. K.; Cronrath, A. R.; Callies, L. K.; Swearer, A. A.; Sethuraman, V.; Ahmed, A. R.; Monstad-Rios, A. T.; Rojas, M. F.; Tang, W. J.; Gardiner, E. M.; Busse, B.; Hsu, Y.-H.; Kwon, R. Y.
10.1101/2021.08.12.456120 — genetics — Posted on 2021-08-20
1268 Discovery of novel putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in AML cells
Lenoir, W. F.; Morgado, M.; DeWeirdt, P. C.; McLaughlin, M.; Griffith, A. L.; Sangree, A. K.; Feeley, M. N.; Esmaeili Anvar, N.; Kim, E.; Colic, M.; Dede, M.; Doench, J. G.; Hart, T.
10.1101/2020.10.08.332023 — genetics — Posted on 2021-08-20
1272 Role of miR-181c in Diet-Induced Obesity Through Regulation of Lipid Synthesis in Liver
Akiyoshi, K.; Boersma, G. J.; Johnson, M. D.; Velasquez, F. C.; Dunkerly-Eyring, B.; OBrien, S.; Yamaguchi, A.; Steenbergen, C.; Tamashiro, K. L. K.; Das, S.
10.1101/2021.08.20.457144 — cell biology — Posted on 2021-08-20
1273 An Essential Role of UBXN3B for B Lymphopoiesis
Geng, T.; Yang, D.; Lin, T.; Harrison, A. G.; Wang, B.; Torrance, B.; Wang, K.; Wang, Y.; Yang, L.; Haynes, L.; Cheng, G.; Vella, A. T.; Fikrig, E.; WANG, P.
10.1101/2021.03.04.433919 — immunology — Posted on 2021-08-20
1274 FKBPL and FKBP8 regulate DLK degradation and neuronal responses to axon injury
Lee, B.; Oh, Y.; Cho, E.; DiAntonio, A.; Cavalli, V.; Shin, J. E.; Cho, Y.
10.1101/2021.08.20.457064 — neuroscience — Posted on 2021-08-20
1275 Model sharing in the human medial temporal lobe
Glitz, L.; Juechems, K.; Summerfield, C.; Garrett, N.
10.1101/2021.06.23.449588 — neuroscience — Posted on 2021-08-20
1278 An ancestral function of strigolactones as symbiotic rhizosphere signals
Kodama, K.; Rich, M. K.; Yoda, A.; Shimazaki, S.; Xie, X.; Akiyama, K.; Mizuno, Y.; Komatsu, A.; Luo, Y.; Suzuki, H.; Kameoka, H.; Libourel, C.; Keller, J.; Sakakibara, K.; Nishiyama, T.; Nakagawa, T.; Mashiguchi, K.; Uchida, K.; Yoneyama, K.; Tanaka, Y.; Yamaguchi, S.; Shimamura, M.; Delaux, P.-M.; Nomura, T.; Kyozuka, J.
10.1101/2021.08.20.457034 — plant biology — Posted on 2021-08-20
1280 Melanomagenesis driven by a kinase-dead mutant BRAF lacking codons 600-618
Girtman, M. A.; Richmond, C. S.; Campbell, M. E.; Rehrauer, W. M.; Kenny, P.
10.1101/2021.08.20.457149 — cancer biology — Posted on 2021-08-20
1282 The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2
Kerk, S. A.; Lin, L.; Myers, A. L.; Zhang, Y.; Jimenez, J. A.; Sajjakulnukit, P.; Nelson, B. S.; Chen, B.; Robinson, A.; Thurston, G.; Kemp, S. B.; Steele, N. G.; Hoffman, M. T.; Wen, H.-J.; Long, D.; Ackenhusen, S. E.; Ramos, J.; Gao, X.; Zhang, L.; Andren, A.; Nwosu, Z. C.; Galban, S.; Halbrook, C. J.; Lombard, D. B.; Piwnica-Worms, D. R.; Ying, H.; Crawford, H. C.; Pasca di Magliano, M.; Shah, Y. M.; Lyssiotis, C. A.
10.1101/2020.08.07.238766 — cancer biology — Posted on 2021-08-20
1283 Cross-scale Analysis of Temperature Compensation in the Cyanobacterial Circadian Clock System
Furuike, Y.; Ouyang, D.; Tominaga, T.; Matsuo, T.; Mukaiyama, A.; Kawakita, Y.; Fujiwara, S.; Akiyama, S.
10.1101/2021.08.20.457041 — biophysics — Posted on 2021-08-20
1287 Identification of sample mix-ups and mixtures in microbiome data in Diversity Outbred mice
Lobo, A. K.; Traeger, L. L.; Keller, M. P.; Attie, A. D.; Rey, F. E.; Broman, K. W.
10.1101/529040 — genetics — Posted on 2021-08-20
1289 Ancestral protein topologies draw the rooted bacterial tree of life
Dimas-Torres, J.-U.; Rodriguez-Hernandez, A.; Valencia-Sanchez, M.-I.; Campos-Chavez, E.; Godinez-Lopez, V.; Rodriguez-Chamorro, D.-E.; Hernandez-Gonzalez, A.; Arciniega, M.; Torres-Larios, A.
10.1101/2021.08.20.456953 — evolutionary biology — Posted on 2021-08-20
1290 Trade-driven trapping dampens the biodiversity benefits of forest restoration in Southeast Asia
Sagar, H. S. S. C.; Gilroy, J. J.; Swinfield, T.; Yong, D. L.; Gemita, E.; Novriyanti, N.; Lee, D. C.; Janra, M. N.; Balmford, A.; Hua, F.
10.1101/2021.08.20.457106 — ecology — Posted on 2021-08-20
1291 The ataxia protein sacsin is required for integrin trafficking and synaptic organization
Romano, L. E. L.; Aw, W. Y.; Hixson, K. M.; Novoselova, T. V.; Havener, T. M.; Howell, S.; Hall, C. L.; Xing, L.; Beri, J.; Nethisinghe, S.; Perna, L.; Hatimy, A.; Chioccioli Altadonna, G.; Graves, L. M.; Herring, L. E.; Hickey, A. J.; Thalassinos, K.; Chapple, J. P.; Wolter, J. M.
10.1101/2021.08.20.456807 — cell biology — Posted on 2021-08-20
1292 Heterotypic Assembly Mechanism Regulates CHIP E3 Ligase Activity
Das, A.; Thapa, P.; Santiago, U.; Shanmugam, N.; Banasiak, K.; Dabrowska, K.; Nolte, H.; Szulc, N. A.; Gathungu, R. M.; Cysewski, D.; Krueger, M.; Dadlez, M.; Nowotny, M.; Camacho, C. J.; Hoppe, T.; Pokrzywa, W.
10.1101/2021.08.20.457118 — molecular biology — Posted on 2021-08-20
1293 Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish
Böhm, U. L.; Kimura, Y.; Kawashima, T.; Ahrens, M.; Higashijima, S.-I.; Engert, F.; Cohen, A. E.
10.1101/2021.08.20.457089 — neuroscience — Posted on 2021-08-20
1294 Course-based Undergraduate Research Module for Enzyme Discovery Using Protein Structure Prediction
Kelz, J. I.; Takahashi, G. R.; Safizadeh, F.; Farahmand, V.; Crosby, M. G.; Uribe, J. L.; Kim, S. H.; Sprague-Piercy, M. A.; Diessner, E. M.; Norton-Baker, B.; Damo, S. M.; Martin, R. W.; Kadandale, P.
10.1101/2021.08.19.456875 — scientific communication and education — Posted on 2021-08-20
1296 Apoplastic class III peroxidases PRX62 and PRX69 regulate ROS-homeostasis and cell wall associated extensins linked to root hair growth at low-temperature in Arabidopsis thaliana
Martinez Pacheco, J.; Ranocha, P.; Kasulin, L.; Fusari, C. M.; Servi, L.; Ferrero, L.; Tapia, P.; Berdion Gabarain, V.; Peralta, J. M.; Borassi, C.; Marzol, E.; Rodriguez Garcia, D. R.; Rondon Guerrero, Y. d. C.; Carignani Sardoy, M.; Botto, J.; Meneses, C.; Ariel, F.; Petrillo, E.; Dunand, C.; Estevez, J.
10.1101/2021.08.20.456256 — plant biology — Posted on 2021-08-20
1297 A Network Approach to Identify Biomarkers of Differential Chemotherapy Response Using Patient-Derived Xenografts of Triple-Negative Breast Cancer
Petrosyan, V.; Dobrolecki, L. E.; Thistlethwaite, L.; Lewis, A. N.; Sallas, C.; Rajaram, R.; Lei, J. T.; Ellis, M. J.; Osborne, K.; Rimawi, M.; Pavlick, A.; Shafaee, M.; Dowst, H.; Saltzman, A. B.; Malovannaya, A.; Marangoni, E.; Welm, A.; Welm, B. E.; Li, S.; Wulf, G.; Sonzogni, O.; Hilsenbeck, S. G.; Milosavljevic, A.; Lewis, M. T.
10.1101/2021.08.20.457116 — cancer biology — Posted on 2021-08-20
1298 Progerin-Expressing Endothelial Cells are Unable to Adapt to Shear Stress
Danielsson, B. E.; Peters, H. C.; Bathula, K.; Spear, L. M.; Noll, N. A.; Dahl, K. N.; Conway, D. E.
10.1101/2021.08.20.456996 — biophysics — Posted on 2021-08-20
1299 Time evolution of PEG-shedding and serum protein coronation determines the cell uptake kinetics and delivery of lipid nanoparticle formulated mRNA
Gallud, A.; Munson, M. J.; Liu, K.; Idstrom, A.; Barriga, H. M.; Tabaei, S.; Aliakbarinodehi, N.; Ojansivu, M.; Lubart, Q.; Doutch, J. J.; Holme, M. N.; Evenas, L.; Lindfors, L.; Stevens, M. M.; Collen, A.; Sabirsh, A.; Hook, F.; Esbjorner, E. K.
10.1101/2021.08.20.457104 — biophysics — Posted on 2021-08-20
1300 Machine learning enables discovery of DNA-carbon nanotube sensors for serotonin
Kelich, P.; Jeong, S.; Navarro, N.; Adams, J.; Sun, X.; Zhao, H.; Landry, M. P.; Vukovic, L.
10.1101/2021.08.20.457145 — bioengineering — Posted on 2021-08-20
1301 Genome of a novel Sediminibacterium discovered in association with two species of freshwater stream Cyanobacteria in Southern California
Sethuraman, A.; Read, B.; Henry, S.; Johansen, H.; Vengerova, G.; Moron-Solano, A.; Kasler, A. M.; Hausknecht-Buss, H.; Caceres, L.; Massaro, I.; Vega, B.; Zhang, A.; Mekuria, I.; Lastor, S.; Sanders, C.; Castro, D.; Hristova, R. S.; Zhang, X.
10.1101/2021.08.20.457134 — genomics — Posted on 2021-08-20
1303 Genetic Characterization and Curation of Diploid A-Genome Wheat Species
Adhikari, L.; Raupp, J.; Wu, S.; Wilson, D.; Evers, B.; Koo, D.-H.; Singh, N.; Friebe, B.; Poland, J.
10.1101/2021.08.20.457122 — genetics — Posted on 2021-08-20
1306 Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors
Shi, G.; Torres Robles, J.; Song, C.; Salichos, L.; Lou, H. J.; Gerstein, M.; Turk, B. E.
10.1101/2021.08.20.457142 — cell biology — Posted on 2021-08-20
1307 Development of a universal nanobody-binding Fab module for fiducial-assisted cryo- EM studies of membrane proteins
Bloch, J. S.; Mukherjee, S.; Kowal, J.; Filippova, E. V.; Niederer, M.; Pardon, E.; Steyaert, J.; Kossiakoff, A. A.; Locher, K. P.
10.1101/2021.08.20.457137 — molecular biology — Posted on 2021-08-20
1309 SARS-CoV-2 hijacks p38β/MAPK11 to promote viral protein translation
Higgins, C. A.; Nilsson-Payant, B. E.; Kurland, A.; Adhikary, P.; Golynker, I.; Danziger, O.; Panis, M.; Rosenberg, B. R.; tenOever, B. R.; Johnson, J. R.
10.1101/2021.08.20.457146 — microbiology — Posted on 2021-08-20
1313 Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice
Subramaniam, S.; Hekman, R. M.; Jayaraman, A.; O'Connell, A. K.; Montanaro, P.; Blum, B.; Kenney, D.; Ericsson, M.; Ravid, K.; A Crossland, N.; Emili, A.; Douam, F.; Bosmann, M.
10.1101/2021.08.19.457020 — immunology — Posted on 2021-08-20
1314 Identification of a conserved neutralizing epitope present on spike proteins from all highly pathogenic coronaviruses
Huang, Y.; Nguyen, A. W.; Hsieh, C.-L.; Silva, R.; Olaluwoye, O. S.; Wilen, R.; Kaoud, T. S.; Azouz, L. R.; Qerqez, A. N.; Le, K. C.; Bohanon, A. L.; DiVenere, A. M.; Liu, Y.; Amengor, D.; Shoemaker, S. R.; Costello, S. M.; Marqusee, S.; Dalby, K.; D'Arcy, S.; McLellan, J. S.; Maynard, J. A.
10.1101/2021.01.31.428824 — biochemistry — Posted on 2021-08-20
1315 High-Spatiotemporal-Resolution Nanopore Sequencing of SARS-CoV-2 and Host Cell RNAs
Tombacz, D.; Dormo, A.; Gulyas, G.; Csabai, Z.; Prazsak, I.; Kakuk, B.; Harangozo, A.; Jankovics, I.; Denes, B.; Boldogkoi, Z.
10.1101/2021.08.20.457128 — genomics — Posted on 2021-08-20
1316 Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway.
Zhou, J.; Peacock, T. P.; Brown, J. C.; Goldhill, D. H.; Elrefaey, A. M. E.; Penrice-Randal, R.; Cowton, V. M.; De Lorenzo, G.; Furnon, W.; Harvey, W. T.; Kugathasan, R.; Frise, R.; Baillon, L.; Lassauniere, R.; Thakur, N.; Gallo, G.; Goldswain, H.; Donovan-Banfield, I.; Dong, X.; Randle, N. P.; Sweeney, F.; Glynn, M. C.; Quantrill, J. L.; McKay, P. F.; Patel, A. H.; Palmarini, M.; Hiscox, J. A.; Bailey, D.; Barclay, W. S.
10.1101/2021.08.20.456972 — microbiology — Posted on 2021-08-20
1318 Rules for the self-assembly of ESCRT-III on endosomes
Sprenger, S.; Migliano, S. M.; Oleschko, F.; Kobald, M.; Hess, M. W.; Teis, D.
10.1101/2021.02.19.431979 — cell biology — Posted on 2021-08-20
1322 Constitutive signal bias mediated by the human GHRHR splice variant 1
Cong, Z.; Zhou, F.; Zhang, C.; Zou, X.; Zhang, H.; Wang, Y.; Zhou, Q.; Cai, X.; Liu, Q.; Li, J.; Shao, L.; Mao, C.; Wang, X.; Wu, J.; Xia, T.; Zhao, L.; Jiang, H.; Zhang, Y.; Xu, H. E.; Cheng, X.; Yang, D.; Wang, M.-W.
10.1101/2021.08.20.457043 — molecular biology — Posted on 2021-08-20
1329 Neurons undergo pathogenic metabolic reprograming in models of familial ALS
Riechers, S.-P.; Mojsilovic-Petrovic, J.; Garjani, M.; Medvedva, V.; Dalton, C.; Dienel, G.; Kalb, R.
10.1101/2021.08.20.457111 — neuroscience — Posted on 2021-08-20
1331 An ancestral function of strigolactones as symbiotic rhizosphere signals
Kodama, K.; Rich, M. K.; Yoda, A.; Shimazaki, S.; Xie, X.; Akiyama, K.; Mizuno, Y.; Komatsu, A.; Luo, Y.; Suzuki, H.; Kameoka, H.; Libourel, C.; Keller, J.; Sakakibara, K.; Nishiyama, T.; Nakagawa, T.; Mashiguchi, K.; Uchida, K.; Yoneyama, K.; Tanaka, Y.; Yamaguchi, S.; Shimamura, M.; Delaux, P.-M.; Nomura, T.; Kyozuka, J.
10.1101/2021.08.20.457034 — plant biology — Posted on 2021-08-20
1335 A nitrite-oxidizing bacterium constitutively consumes atmospheric hydrogen
Leung, P. M.; Daebeler, A.; Chiri, E.; Cordero, P. R. F.; Hanchapola, I.; Gillett, D. L.; Schittenhelm, R. B.; Daims, H.; Greening, C.
10.1101/2021.08.20.457082 — microbiology — Posted on 2021-08-20
1336 Dysfunction of grey matter NG2 glial cells affects neuronal plasticity and behavior
Timmermann, A.; Jabs, R.; Boehlen, A.; Domingos, C.; Skubal, M.; Huang, W.; Kirchhoff, F.; Henneberger, C.; Bilkei-Gorzo, A.; Seifert, G.; Steinhauser, C. W.
10.1101/2021.08.20.457086 — neuroscience — Posted on 2021-08-20
1337 Quantification of macromolecular biomass composition for constraint-based metabolic modeling
Simensen, V.; Schulz, C.; Karlsen, E.; Bratelund, S.; Burgos, I.; Thorfinnsdottir, L. B.; Garcia-Calvo, L.; Bruheim, P.; Almaas, E.
10.1101/2021.08.20.457062 — systems biology — Posted on 2021-08-20
1338 Optimized Data-Independent Acquisition Approach for Proteomic Analysis at Single-Cell Level
Wang, Y.; Lih, T.-S. M.; Chen, L.; Xu, Y.; Kuczler, M. D.; Cao, L.; Pienta, K. J.; Amend, S. R.; Zhang, H.
10.1101/2021.08.19.457000 — systems biology — Posted on 2021-08-20
1339 Organ protection by caloric restriction depends on activation of the de novo NAD+ synthesis pathway
Spaeth, M. R.; Hoyer-Allo, K. J. R.; Johnsen, M.; Hoehne, M.; Lucas, C.; Brodesser, S.; Lackmann, J.-W.; Kiefer, K.; Koehler, F. C.; Schiller, P.; Kubacki, T.; Grundmann, F.; Benzing, T.; Schermer, B.; Burst, V.; Mueller, R.-U.
10.1101/2021.08.20.457042 — physiology — Posted on 2021-08-20
1341 Type I PRMTs and PRMT5 Inversely Regulate Post-Transcriptional Intron Detention
Maron, M. I.; Casill, A. D.; Gupta, V.; Sidoli, S.; Query, C. C.; Gamble, M. J.; Shechter, D.
10.1101/2021.08.20.457069 — cancer biology — Posted on 2021-08-20
1343 Sequence grammar underlying unfolding and phase separation of globular proteins
Ruff, K. M.; Choi, Y. H.; Cox, D.; Ormsby, A. R.; Myung, Y.; Ascher, D. B.; Radford, S. E.; Pappu, R. V.; Hatters, D. M.
10.1101/2021.08.20.457073 — biophysics — Posted on 2021-08-20
1345 Nanomechanics combined with HDX reveal allosteric drug binding sites of CFTR NBD1
Padanyi, R.; Farkas, B.; Tordai, H.; Kiss, B.; Grubmuller, H.; Soya, N.; Lukacs, G.; Kellermayer, M.; Hegedus, T.
10.1101/2021.08.20.457065 — biophysics — Posted on 2021-08-20
1347 Frequent Aneuploidy in Primary Human T Cells Following CRISPR-Cas9 cleavage
Nahmad, A. D.; Reuveni, E.; Goldschmidt, E.; Tenne, T.; Liberman, M.; Horovitz-Fried, M.; Khosravi, R.; Kobo, H.; Reinstein, E.; Madi, A.; Ben-David, U.; Barzel, A.
10.1101/2021.08.20.457092 — bioengineering — Posted on 2021-08-20
1348 Acoustic light-sheet microscopy
Wunderl, S.; Ishijima, A.; Susaki, E.; Xu, Z.; Song, H.; Zha, H.; Azuma, T.; Sakuma, I.; Fukuoka, H.; Okada, E.; Ueda, H. R.; Takagi, S.; Nakagawa, K.
10.1101/2021.08.20.457051 — bioengineering — Posted on 2021-08-20
1357 Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1
Mudgal, R.; Bharadwaj, C.; Dubey, A.; Choudhary, S.; Nagarajan, P.; Aggarwal, M.; Ratra, Y.; Basak, S.; Tomar, S.
10.1101/2021.08.19.457046 — immunology — Posted on 2021-08-20
1358 CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature
Singhania, A.; Dubelko, P.; Kuan, R.; Chronister, W. D.; Muskat, K.; Das, J.; Phillips, E. J.; Mallal, S. A.; Seumois, G.; Vijayanand, P.; Sette, A.; Lerm, M.; Peters, B.; Lindestam Arlehamn, C. S.
10.1101/2021.08.20.457054 — immunology — Posted on 2021-08-20
1359 Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration.
Senabouth, A.; Daniszewski, M.; Lidgerwood, G.; Liang, H.; Hernandez, D.; Mirzaei, M.; Zhang, R.; Han, X.; Neavin, D.; Rooney, L.; Lopez Sanchez, I.; Gulluyan, L.; Paulo, J.; Clarke, L.; Kearns, L.; Gnanasambandapillai, V.; Chan, C.-L.; Nguyen, U.; Steinmann, A.; Zekanovic, R.; Farbehi, N.; Gupta, V.; Mackey, D.; Bylsma, G.; Verma, N.; MacGregor, S.; Guymer, R.; Powell, J.; Hewitt, A. W.; Pebay, A.
10.1101/2021.08.19.457044 — neuroscience — Posted on 2021-08-20
1360 Liquid-liquid phase separation of florigen activation complex induces flowering
Taoka, K.-i.; Tsuji, H.; Anzawa, S.; Enomoto, M.; Koizumi, Y.; Nakamura, J.; Tanaka, M.; Fujita, A.; Furuita, K.; Kodama, T. S.; Fujimoto, M.; Kurokawa, K.; Okamoto, T.; Fujiwara, T.; Nakano, A.; Kojima, C.
10.1101/2021.08.19.456992 — plant biology — Posted on 2021-08-20
1361 Optimized detection of somatic allelic imbalances specific for homologous recombination deficiency improves the prediction of clinical outcomes in ovarian cancer
Perez-Villatoro, F.; Oikkonen, J.; Casado, J.; Chernenko, A.; Gulhan, D. C.; Tumiati, M.; Li, Y.; Lavikka, K.; Hietanen, S.; Hynninen, J.; Haltia, U.-M.; Tyrmi, J. S.; Laivuori, H.; Konstantinopoulos, P.; Hautaniemi, S.; Kauppi, L.; Farkkila, A.
10.1101/2021.08.19.456809 — cancer biology — Posted on 2021-08-20
1363 Sex-specific body mass ageing trajectories in adult Asian elephants
Lalande, L. D.; Lummaa, V.; Aung, H. H.; Htut, W.; Nyein, U. K.; Berger, V.; Briga, M.
10.1101/2020.12.17.423208 — evolutionary biology — Posted on 2021-08-20
1364 A-to-I mRNA editing in a ferric siderophore receptor improves competition for iron in Xanthomonas oryzae
Nie, W.; Wang, S.; Huang, J.; Xu, Q.; Wang, P.; Wu, Y.; Yiming, A.; Ahmad, I.; Zhu, B.; Chen, G.
10.1101/2020.12.03.409276 — microbiology — Posted on 2021-08-20
1366 MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state
Mehravar, M.; Kumar, Y.; Olshansky, M.; Bansal, D.; Dent, C.; Hathiwala, D.; Zhang, Z.; Gandhi, H.; Fulcher, A.; Huang, C.; Price, J.; Arumugam, S.; Ceman, S.; Balasubramanian, S.; Papas, B. N.; Morgan, M.; Miska, E. A.; Schittenhelm, R. B.; Tripathi, P.; Das, P. P.
10.1101/2021.08.11.456030 — biochemistry — Posted on 2021-08-20
1367 Signatures of adaptive evolution in platyrrhine primate genomes
Byrne, H.; Webster, T. H.; Brosnan, S. F.; Izar, P.; Lynch, J. W.
10.1101/2021.08.19.456368 — genomics — Posted on 2021-08-20
1370 NEST Desktop - An educational application for neuroscience
Spreizer, S.; Senk, J.; Rotter, S.; Diesmann, M.; Weyers, B.
10.1101/2021.06.15.444791 — neuroscience — Posted on 2021-08-20
1374 Subthreshold repetitive transcranial magnetic stimulation drives structural synaptic plasticity in the young and aged motor cortex.
Tang, A.; Bennett, W.; Bindoff, A.; Bolland, S.; Collins, J.; Langley, R.; Garry, M.; Summers, J.; Hinder, M.; Rodger, J.; Canty, A.
10.1101/2021.03.10.434706 — neuroscience — Posted on 2021-08-20
1375 Coherent mapping of position and head direction across auditory and visual cortex
Mertens, P. E. C.; Marchesi, P.; Oude Lohuis, M. N.; Krijger, Q.; Pennartz, C. M. A.; Lansink, C. S.
10.1101/2021.07.30.452931 — neuroscience — Posted on 2021-08-20
1376 Model sharing in the human medial temporal lobe
Glitz, L.; Juechems, K.; Summerfield, C.; Garrett, N. P.
10.1101/2021.06.23.449588 — neuroscience — Posted on 2021-08-20
1381 Tomato CRABS CLAW paralogues interact with chromatin remodelling factors to mediate carpel development and floral determinacy
Castaneda, L.; Gimenez, E.; Pineda, B.; Garcia-Sogo, B.; Ortiz, A.; Micol-Ponce, R.; Angosto, T.; Capel, J.; Moreno, V.; Yuste-Lisbona, F. J.; Lozano, R.
10.1101/2021.08.19.456989 — developmental biology — Posted on 2021-08-20
1382 Determinants shaping the nanoscale architecture of the mouse rod outer segment
Pöge, M.; Mahamid, J.; Imanishi, S. S.; Plitzko, J. M.; Palczewski, K.; Baumeister, W.
10.1101/2021.08.18.456753 — cell biology — Posted on 2021-08-20
1384 Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques.
Fouda, G. G.; Berendam, S. J.; Morgan-Asiedu, P. K.; Mangan, R. J.; Li, S.; Heimsath, H.; Luo, K.; Curtis, A. D.; Eudailey, J. A.; Fox, C. B.; Tomai, M. A.; Phillips, B.; Itell, H. L.; Kunz, E.; Hudgens, M.; Cronin, K.; Wiehe, K.; Alam, S. M.; Van Rompay, K. K. A.; De Paris, K.; Permar, S. R.; Moody, M. A.
10.1101/2021.08.18.456876 — immunology — Posted on 2021-08-20
1387 Village in a dish: a model system for population-scale hiPSC studies
Neavin, D.; Murphy, A.; Chiu, H.; Daniszewski, M.; Moutinho, C.; Chan, C.-L.; Tyebally, R.; Gnanasambandapillai, V.; Lam, E.; Nguyen, U.; Herbnandez, D.; Lindgerwood, G.; Hewitt, A. W.; Pebay, A.; Palpant, N.; Powell, J.
10.1101/2021.08.19.457030 — genomics — Posted on 2021-08-19
1390 The DNA sensors AIM2 and IFI16 are NET-binding SLE autoantigens
Antiochos, B.; Fenaroli, P.; Rosenberg, A.; Baer, A.; Sohn, J.; Li, J.; Petri, M.; Goldman, D. W.; Mecoli, C.; Casciola-Rosen, L.; Rosen, A.
10.1101/2021.08.19.456941 — immunology — Posted on 2021-08-19
1391 Pre-vaccination Frequency of Circulatory Tfh is associated with Robust Immune Response to TV003 Dengue Vaccine
Izmilry, A. M.; Pelletier, A.-N.; Connors, J.; Taramangalam, B.; Alturki, S. O.; Gordon, E. A.; Alturki, S. O.; Mell, J. C.; Swaminathan, G.; Karthik, V.; Kutzler, M. A.; Kallas, E.; Sekaly, R.-P.; Haddad, E. K.
10.1101/2021.08.19.456926 — immunology — Posted on 2021-08-19
1392 Synthetic antigen presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.
Cespedes, P. F.; Jainarayanan, A. K.; Fernandez-Messina, L.; Valvo, S.; Saliba, D. G.; Kvalvaag, A.; Chen, L.; Kurz, E.; Ganskow, C.; Colin-York, H.; Fritzsche, M.; Yanchun, P.; Dong, T.; Johnson, E.; Siller-Farfan, J. A.; Dushek, O.; Sezgin, E.; Peacock, B.; Law, A.; Aubert, D.; Engledow, S.; Attar, M.; Hester, S.; Fisher, R.; Sanchez-Madrid, F.; Dustin, M. L.
10.1101/2021.05.29.445691 — immunology — Posted on 2021-08-19
1393 Inter-Subject EEG Correlation Reflects Time-Varying Engagement with Natural Music
Kaneshiro, B.; Nguyen, D. T.; Norcia, A. M.; Dmochowski, J. P.; Berger, J.
10.1101/2021.04.14.439913 — neuroscience — Posted on 2021-08-19
1395 ITRAQ-based quantitative proteomic analysis of japonica rice seedling during cold stress
Qing, D.; Pan, Y.; Dai, G.; Gao, L.; Liang, H.; Zhou, W.; Chen, W.; Li, J.; Huang, J.; Gao, J.; Wu, H.; Lu, C.; Liu, K.; Deng, G.
10.1101/2021.08.19.457014 — plant biology — Posted on 2021-08-19
1400 scFlow: A Scalable and Reproducible Analysis Pipeline for Single-Cell RNA Sequencing Data
Khozoie, C.; Fancy, N.; Marjaneh, M. M.; Murphy, A. E.; Matthews, P. M.; Skene, N.
10.1101/2021.08.16.456499 — bioinformatics — Posted on 2021-08-19
1402 Gene expression in African Americans and Latinos reveals ancestry-specific patterns of genetic architecture
Mak, A. C. Y.; Kachuri, L.; Hu, D.; Eng, C.; Huntsman, S.; Elhawary, J. R.; Gupta, N.; Gabriel, S.; Xiao, S.; Gui, H.; Keys, K. L.; Oni-Orisan, A.; Oh, S. S.; Seibold, M. A.; Rodriguez-Santana, J. R.; LeNoir, M. A.; Williams, L. K.; Borrell, L. N.; Gignoux, C. R.; Zaitlen, N. A.; Burchard, E. G.; Ziv, E.
10.1101/2021.08.19.456901 — genetics — Posted on 2021-08-19
1403 Harbor porpoise losing its edges: genetic time series suggests a rapid population decline in Iberian waters over the last 30 years
Ben Chehida, Y.; Stelwagen, T.; Hoekendijk, J. P. A.; Ferreira, M.; Eira, C.; Pereira, A. T.; Nicolau, L.; Thumloup, J.; Fontaine, M. C.
10.1101/2021.08.19.456945 — evolutionary biology — Posted on 2021-08-19
1408 An siRNA-guided Argonaute protein directs RNA Polymerase V to initiate DNA methylation
Sigman, M. J.; Panda, K.; Kirchner, R.; McLain, L. L.; Payne, H.; Peasari, J. R.; Husbands, A. Y.; Slotkin, R. K.; McCue, A. D.
10.1101/2021.08.19.457027 — plant biology — Posted on 2021-08-19
1409 MINK1 modulates 5FU resistance in OSCC through AKT/MDM2 mediated regulation of p53
Mohanty, S.; Mohapatra, P.; Shriwas, O.; Priyadarshini, M.; Ansari, S. A.; Priyadarsini, S.; Rath, R.; Sultania, M.; Das Majumdar, S. K.; Dash, R.
10.1101/2021.08.19.456939 — cancer biology — Posted on 2021-08-19
1411 Multi view based imaging genetics analysis on Parkinson disease
Cerri, G.; Tognon, M.; Avesani, S.; Oxtoby, N.; Altmann, A.; Giugno, R.
10.1101/2021.08.19.456943 — bioinformatics — Posted on 2021-08-19
1413 wnt16 exerts pleiotropic effects on bone and lean mass in zebrafish
Watson, C. J.; Morfin Montes de Oca, E.; Fiedler, I. A. K.; Cronrath, A. R.; Callies, L. K.; Swearer, A. A.; Sethuraman, V.; Ahmed, A. R.; Monstad-Rios, A. T.; Rojas, M. F.; Tang, W. J.; Gardiner, E. M.; Busse, B.; Hsu, Y.-H.; Kwon, R. Y.
10.1101/2021.08.12.456120 — genetics — Posted on 2021-08-19
1414 Shaping coral traits: plasticity more than filtering
Brambilla, V.; Barbosa, M.; Dehnert, I.; Madin, J. S.; Maggioni, D.; Peddie, C.; Dornelas, M.
10.1101/2021.08.19.456946 — ecology — Posted on 2021-08-19
1416 Isolation, omics characterization and organotypic culture of alveolar type II pulmonary epithelial cells
Li, H.; Schuette, M.; Bober, M.; Kroll, T.; Frappart, L.; Bou About, G.; Lin, Y.-C.; Sorg, T.; Herault, Y.; Wierling, C.; Rinner, O.; Lange, B. M.; Ploubidou, A.
10.1101/2021.08.19.456947 — cell biology — Posted on 2021-08-19
1417 Single-cell transcriptomic assessment of cellular phenotype stability in human precision-cut lung slices
Winters, N. I.; Taylor, C. J.; Jetter, C. S.; Camarata, J. E.; Gutierrez, A. J.; Bui, L. T.; Gokey, J. J.; Bacchetta, M.; Banovich, N. E.; Sucre, J. M. S.; Kropski, J. A.
10.1101/2021.08.19.457016 — cell biology — Posted on 2021-08-19
1421 The underlying mechanisms of improved balance after one and ten sessions of balance training in older adults
Alizadehsaravi, L.; Koster, R. A. J.; Muijres, W.; Maas, H.; Bruijn, S. M.; van Dieen, J. H.
10.1101/2020.10.01.322313 — neuroscience — Posted on 2021-08-19
1429 Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia
Tirtakusuma, R.; Szoltysek, K.; Milne, P.; Grinev, V. V.; Ptasinska, A.; Meyer, C.; Nakjang, S.; Hehir-Kwa, J. Y.; Williamson, D.; Cauchy, P.; Assi, S. A.; Imperato, M. R.; Vogiatzi, F.; Lin, S.; Wunderlich, M.; Stutterheim, J.; Komkov, A.; Zerkalenkova, E.; Evans, P.; McNeill, H.; Elder, A.; Martinez Soria, N.; Fordham, S. E.; Shi, Y.; Russell, L. J.; Pal, D.; Smith, A.; Kingsbury, Z.; Becq, J.; Eckert, C.; Haas, O. A.; Carey, P.; Bailey, S.; Skinner, R.; Miakova, N.; Collin, M.; Bigley, V.; Haniffa, M.; Marschalek, R.; Harrison, C. J.; Cargo, C. A.; Schewe, D.; Olshanskaya, Y.; Thirman, M. J
10.1101/2021.07.16.452676 — cancer biology — Posted on 2021-08-19
1431 Quantifying bacterial evolution in the wild: a birthday problem for Campylobacter lineages
Calland, J. K.; Pascoe, B.; Bayliss, S. C.; Mourkas, E.; Berthenet, E.; Thorpe, H. A.; Hitchings, M. D.; Feil, E. J.; Corander, J.; Blaser, M. J.; Falush, D.; Sheppard, S. K.
10.1101/2020.12.02.407999 — genomics — Posted on 2021-08-19
1432 Long-read sequencing reveals rapid evolution of immunity- and cancer-related genes in bats
Scheben, A.; Mendivil Ramos, O.; Kramer, M.; Goodwin, S.; Oppenheim, S. J.; Becker, D. J.; Schatz, M. C.; Simmons, N. B.; Siepel, A.; McCombie, W. R.
10.1101/2020.09.09.290502 — genomics — Posted on 2021-08-19
1433 Global prevalence of potentially pathogenic short-tandem repeats in an epilepsy cohort
Moreau, C.; Michaud, J. L.; Hamdan, F. F.; Bouchard, J.; Tremblay, V.; Minassian, B. A.; Cossette, P.; Girard, S. L.
10.1101/2020.08.20.259168 — genetics — Posted on 2021-08-19
1434 Patterning the embryonic pulmonary mesenchyme
Goodwin, K.; Jaslove, J. M.; Tao, H.; Zhu, M.; Hopyan, S.; Nelson, C. M.
10.1101/2020.08.20.259101 — developmental biology — Posted on 2021-08-19
1435 Highly scaled measurements of C. elegans development suggest that physical constraints guide growth trajectories and animal shape
Nyaanga, J.; Goss, C.; Zhang, G.; Ahmed, H. N.; Andersen, E. J.; Miller, I. R.; Rozenich, J. K.; Swarthout, I. L.; Vaughn, J. A.; Andersen, E. C.; Mangan, N. M.; Shirman, S.
10.1101/2021.04.01.438121 — developmental biology — Posted on 2021-08-19
1439 Mayaro Virus Infection Elicits an Innate Immune Response in Anopheles stephensi
Henderson, C. A.; Brustolin, M.; Hegde, S.; Dayama, G.; Lau, N.; Hughes, G.; Bergey, C.; Rasgon, J. L.
10.1101/2020.11.15.383596 — microbiology — Posted on 2021-08-19
1444 Evolutionary analysis of the LORELEI gene family in angiosperms reveals regulatory subfunctionalization
Noble, J. A.; Bielski, N. V.; Liu, M.-C. J.; DeFalco, T. A.; Stegmann, M.; Nelson, A. D. L.; McNamara, K.; Sullivan, B.; Dinh, K. K.; Khuu, N.; Hancock, S.; Shiu, S.-H.; Zipfel, C.; Cheung, A. Y.; Beilstein, M. A.; Palanivelu, R.
10.1101/2020.04.27.062893 — plant biology — Posted on 2021-08-19
1447 Somatic mutation rates scale with lifespan across mammals
Cagan, A.; Baez-Ortega, A.; Brzozowska, N.; Abascal, F.; Coorens, T. H. H.; Sanders, M. A.; Lawson, A. R. J.; Harvey, L. M. R.; Bhosle, S. G.; Jones, D.; Alcantara, R. E.; Butler, T. M.; Hooks, Y.; Roberts, K.; Anderson, E.; Flach, E.; Spiro, S.; Januszczak, I.; Wrigglesworth, E.; Perkins, M. W.; Deaville, R.; Druce, M.; Bogeska, R.; Milsom, M. D.; Neumann, B.; Gorman, F.; Constantino-Casas, F.; Peachey, L.; Bochynska, D.; Smith, E. S. J.; Gerstung, M.; Campbell, P. J.; Murchison, E. P.; Stratton, M. R.; Martincorena, I.
10.1101/2021.08.19.456982 — genomics — Posted on 2021-08-19
1448 Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains
Elvers, K. T.; Lipka-Lloyd, M.; Trueman, R. C.; Bax, B. D.; Mehellou, Y.
10.1101/2021.08.19.456998 — biochemistry — Posted on 2021-08-19
1449 Mapping of genotype-by-environment interactions in phenology identifies two cues for flowering in switchgrass (Panicum virgatum)
MacQueen, A. H.; Zhang, L.; Bonette, J.; Boe, A. R.; Fay, P. A.; Fritschi, F. B.; Lowry, D. B.; Mitchell, R. B.; Rouquette, F. M.; Wu, Y.; Juenger, T. E.
10.1101/2021.08.19.456975 — genetics — Posted on 2021-08-19
1452 Ethology of morphogenesis reveals the design principles of cnidarian size and shape development
Stokkermans, A.; Chakrabarti, A.; Wang, L.; Moghe, P.; Subramanian, K.; Steenbergen, P.; Moenke, G.; Hiiragi, T.; Prevedel, R.; Mahadevan, L.; Ikmi, A.
10.1101/2021.08.19.456976 — developmental biology — Posted on 2021-08-19
1453 Stromal-cell deletion of STAT3 protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
Ajay, A. K.; Zhao, L.; Vig, S.; Fujiwara, M.; Thakurela, S.; Jadhav, S.; Chiu, I.-J.; Ding, Y.; Ramachandran, K. K.; Mittal, A.; Bhatt, A.; Chaluvadi, P.; Gupta, M. K.; Sabbisetti, V. S.; Waaga-Gasser, A. M.; Gopal, M.; Frank, D. A.; Bonventre, J. V.; Hsiao, L.-L.
10.1101/2021.08.19.456872 — cell biology — Posted on 2021-08-19
1455 XAV-19, a swine glyco-humanized polyclonal antibody against SARS-CoV-2 Spike receptor-binding domain, targets multiple epitopes and broadly neutralizes variants.
Vanhove, B.; Marot, S. S.; So, R.; Gaborit, B.; Evanno, G.; Malet, I.; Lafrogne, G.; Mevel, E.; Ciron, C.; Royer, P.-J.; Lheriteau, E.; Raffi, F.; Bruzzone, R.; Mok, C. K. P.; Duvaux, O.; Marcelin, A.-G.; Calvez, V.
10.1101/2021.04.02.437747 — immunology — Posted on 2021-08-19
1458 Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation
Humphries, J. D.; Zha, J.; Burns, J.; Askari, J. A.; Below, C. R.; Chastney, M. R.; Jones, M. C.; Mironov, A.; Knight, D.; O'Reilly, D. A.; Dunne, M. J.; Garrod, D. R.; Jorgensen, C.; Humphries, M. J.
10.1101/2021.08.19.456969 — cancer biology — Posted on 2021-08-19
1462 ReporterSeq reveals genome-wide determinants of proteasome expression
Work, J. J.; Alford, B. D.; Dea, A.; Ali, A.; Pincus, D.; Brandman, O.
10.1101/2021.08.19.456712 — genomics — Posted on 2021-08-19
1466 Lifelong single-cell profiling of cranial neural crest diversification
Fabian, P.; Tseng, K.-C.; Thiruppathy, M.; Arata, C.; Chen, H.-J.; Smeeton, J.; Nelson, N.; Crump, J. G.
10.1101/2021.08.19.456710 — developmental biology — Posted on 2021-08-19
1467 GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence.
van Rheenen, J.; Hol, E.; Vennin, C.; van Asperen, J.; Uceda-Castro, R.; Sluijs, J.; van Bodegraven, E.; Margarido, A. d. C.; Robe, P.
10.1101/2021.08.19.456978 — cell biology — Posted on 2021-08-19
1468 Critical Role for Isoprenoids in Apicoplast Biogenesis by Malaria Parasites
Okada, M.; Rajaram, K.; Swift, R. P.; Mixon, A.; Maschek, J. A.; Prigge, S. T.; Sigala, P. A.
10.1101/2021.08.19.456988 — microbiology — Posted on 2021-08-19
1470 Stabilising microbial communities by looped mass transfer
Li, S.; Abdulkadir, N.; Schattenberg, F.; Nunes da Rocha, U.; Grimm, V.; Muller, S.; Liu, Z.
10.1101/2021.08.19.456962 — microbiology — Posted on 2021-08-19
1477 White matter microstructure shows sex differences in late childhood: Evidence from 6,797 children
Lawrence, K. E.; Abaryan, Z.; Laltoo, E.; Hernandez, L. M.; Gandal, M.; McCracken, J. T.; Thompson, P. M.
10.1101/2021.08.19.456728 — neuroscience — Posted on 2021-08-19
1479 Specific BRCA and immune configurations determine optimal response to platinum-based chemotherapy in triple negative breast and ovarian carcinomas
Menghi, F.; Banda, K.; Kumar, P.; Straub, R.; Dobrolecki, L.; Rodriguez, I. V.; Yost, S. E.; Chandok, H.; Radke, M. R.; Zhu, A. S.; Somlo, G.; Yuan, Y.; Lewis, M. T.; Swisher, E. M.; Liu, E. T.
10.1101/2021.08.19.456799 — cancer biology — Posted on 2021-08-19
1482 Pandemic, epidemic, endemic: B cell repertoire analysis reveals unique anti-viral responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus
Stewart, A.; Sinclair, E.; Ng, J. C.; Fraternali, F.; Silvia-O'Hare, J.; Page, A.; Serangeli, I.; Margreitter, C.; Kasar, N.; Longman, K.; Frampas, C.; Lewis, H.-M.; Costa, C.; Wu, B.; Kipling, D.; Openshaw, P.; Chiu, C.; Baillie, J. K.; Scott, J.; Semple, M.; Bailey, M.; Dunn-Walters, D.
10.1101/2021.08.19.456951 — immunology — Posted on 2021-08-19
1483 Effects of Hydroxychloroquine and Azithromycin on iPSC-derived Cardiomyocytes: Considerations for the Treatment of COVID-19 Patients
Li, W.; Luo, X.; Poetsch, M. S.; Oertel, R.; Nichani, K.; Schneider, M.; Strano, A.; Hasse, M.; Steiner, R. P.; Cyganek, L.; Hettwer, K.; Uhlig, S.; Simon, K.; Guan, K.; Schubert, M.
10.1101/2021.08.19.456950 — pharmacology and toxicology — Posted on 2021-08-19
1486 Neutralising antibodies against the SARS-CoV-2 Delta variant induced by Alhydroxyquim-II-adjuvanted trimeric spike antigens
Counoupas, C.; Pino, P.; Stella, A.; Ashley, C.; Lukeman, H.; Bhattacharyya, N.; Tada, T.; Anchisi, S.; Metayer, C.; Martinis, J.; Aggarwal, A.; Dcosta, B.; Kint, J.; Wurm, M.; Landau, N.; Steain, M.; Turville, S.; Wurm, F.; David, S.; Triccas, J. A.
10.1101/2021.08.18.456891 — microbiology — Posted on 2021-08-19
1487 Characterising the Photoplethysmography Pulse Waveform for Use in Human Neuroscience: The Hybrid Excess and Decay (HED) Model
Williamson, S.; Daniel-Watanabe, L.; Finnemann, J.; Powell, C.; Teed, A.; Allen, M.; Paulus, M. P.; Khalsa, S. S.; Fletcher, P. C.
10.1101/2021.08.19.456935 — neuroscience — Posted on 2021-08-19
1488 A bacterial genome and culture collection of gut microbial in weanling piglet
Dong, B.; Lin, X.; Jing, X.; Hu, T.; Zhou, J.; Xiao, L.; Wang, B.; Chen, Z.; Liu, J.; Hu, Y.; Liu, G.; Liu, S.; Liu, J.; Wei, W.; Zou, Y.
10.1101/2021.08.18.456900 — microbiology — Posted on 2021-08-19
1489 A method for high throughput image based antifungal screening
Sabburg, R.; Gregson, A.; Urquhart, A. S.; Aitken, E. A. B.; Smith, L.; Thatcher, L. F.; Gardiner, D. M.
10.1101/2021.08.18.456906 — microbiology — Posted on 2021-08-19
1490 Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites
Lansink, L. I. M.; Engel, J. A.; Lee, H. J.; Soon, M. S. F.; Williams, C. G.; SheelaNair, A.; Pernold, C. P. S.; Laohamonthonkul, P.; Akter, J.; Stoll, T.; Hill, M. M.; Talman, A. M.; Russell, A. J. C.; Lawniczak, M.; Davenport, M. P.; Khoury, D. S.; Haque, A.
10.1101/2021.08.18.456784 — microbiology — Posted on 2021-08-19
1492 MEKK3-TGFβ crosstalk regulates inward arterial remodeling
Deng, H.; Xu, Y.; Hu, X.; Zhuang, Z. W.; Chang, Y.; Wang, Y.; Ntokou, A.; Schwartz, M. A.; Su, B.; Simons, M.
10.1101/2021.08.19.456893 — pathology — Posted on 2021-08-19
1494 Deploying an in vitro gut model to assay the impact of a mannan-oligosaccharide prebiotic, Bio-Mos(R) on the Atlantic salmon (Salmo salar) gut microbiome.
Kazlauskaite, R.; Cheaib, B.; Humble, J. L.; Heys, C.; Ijaz, U. Z.; Connelly, S.; Sloan, W.; McGinnity, P.; llewellyn, M.; Russell, J.; Rubio, L. M.; Sweetman, J.; Lyons, P.; Kitts, A.
10.1101/2021.08.18.456921 — bioengineering — Posted on 2021-08-19
1495 Impact of Human Serum Proteins on Susceptibility of Acinetobacter baumannii to Cefiderocol: role of iron transport
Le, C.; Pimentel, C.; Pasteran, F.; Tuttobene, M. R.; Subils, T.; Escalante, J.; Nishimura, B.; Arriaga, S.; Carranza, A.; Vila, A. J.; Corso, A.; Actis, L. A.; Tolmasky, M.; Bonomo, R. A.; Ramirez, M. S.
10.1101/2021.08.18.456922 — microbiology — Posted on 2021-08-19
1496 Excess dietary sugar impairs colonic epithelial regeneration in response to damage.
Burr, A.; Ji, J.; Ozler, K.; Eskiocak, O.; Yueh, B.; Menk, A. V.; Costa, A. S. H.; Rittenhouse, N.; Marshall, C. W.; Chiaranunt, P.; Mullinax, L.; Overacre-Delgoffe, A.; Cooper, V. S.; Poholek, A. C.; Delgoffe, G. M.; Beyaz, S.; Hand, T.
10.1101/2021.08.18.456840 — immunology — Posted on 2021-08-19
1501 Aβ toxicity rescued by protein retention in the ER
Catterson, J. H.; Minkley, L.; Aspe, S.; Judd-Mole, S.; Moura, S.; Dyson, M. C.; Rajasingam, A.; Woodling, N. S.; Atilano, M. L.; Ahmad, M.; Durrant, C. S.; Spires-Jones, T. L.; Partridge, L.
10.1101/2021.08.18.456775 — neuroscience — Posted on 2021-08-19
1502 The genome of stress tolerant crop wild relativePaspalum vaginatum leads to increased biomassproductivity in the crop Zea mays
Sun, G.; Wase, N.; Shu, S.; Jenkins, J.; Zhou, B.; Chen, C.; Sandor, L.; Plott, C.; Yoshinga, Y.; Daum, C.; Qi, P.; Barry, K. W.; Lipzen, A.; Berry, L.; Gottilla, T.; Foltz, A.; Yu, H.; O'Malley, R. C.; Zhang, C.; Devos, K. M.; Sigmon, B.; Yu, B.; Obata, T.; Schmutz, J.; Schnable, J. C.
10.1101/2021.08.18.456832 — plant biology — Posted on 2021-08-19
1503 Microbiota induces aging-related leaky gut and inflammation by dampening mucin barriers and butyrate-FFAR2/3 signaling
Mishra, S. P.; Wang, B.; Wang, S.; Nagpal, R.; Miller, B.; Jain, S.; Lee, J. Y.; Borlongan, C.; Taraphder, S.; Rane, S. G.; Yadav, H.
10.1101/2021.08.18.456856 — physiology — Posted on 2021-08-19
1504 Comparative Molecular Genomic Analyses of a Spontaneous Rhesus Macaque Model of Mismatch Repair-Deficient Colorectal Cancer
Ozirmak Lermi, N.; Gray, S. B.; Bowen, C. M.; Reyes-Uribe, L.; Dray, B. K.; Deng, N.; Harris, R. A.; Raveendran, M.; Benavides, F.; Hodo, C. L.; Taggart, M. W.; Colbert Maresso, K.; Sinha, K. M.; Rogers, J.; Vilar, E.
10.1101/2021.08.19.456691 — cancer biology — Posted on 2021-08-19
1505 Axonal T2 estimation using the spherical variance of the strongly diffusion-weighted MRI signal
Pizzolato, M.; Andersson, M.; Canales-Rodriguez, E. J.; Thiran, J.-P.; Dyrby, T. B.
10.1101/2021.08.19.456817 — biophysics — Posted on 2021-08-19
1508 CytoPro: A computational platform for accurate and robust assessment of cell contributions in bulk expression from diverse tissues and conditions
Katz, A.; Gaujoux, R.; Orly, H.; Starosvetsky, E.; Rozov, R.; Rabinovitch, Y.; Halberstadt, B.; Bar, L.; Spector, Y.; Wald, N.; Rubin, C.; Benita, Y.; Gerassy-Vainberg, S.; Shen-Orr, S. S.
10.1101/2021.08.19.456930 — bioinformatics — Posted on 2021-08-19
1509 Conformable and robust force sensors to enable precision joint replacement surgery
Ives, L.; Pace, A.; Bor, F.; Jing, Q.; Wade, T.; Cama, J.; Khanduja, V.; Kar-Narayan, S.
10.1101/2021.08.19.456934 — bioengineering — Posted on 2021-08-19
1510 Structure-Function in Helical Cardiac Musculature Using Additive Textile Manufacturing
Chang, H.; Liu, Q.; Zimmerman, J. F.; Lee, K. Y.; Jin, Q.; Peters, M. M.; Rosnach, M.; Choi, S.; Kim, S. L.; Ardona, H. A. M.; MacQueen, L. A.; Chantre, C. O.; Motta, S. E.; Cordoves, E. M.; Parker, K. K.
10.1101/2021.08.18.456852 — bioengineering — Posted on 2021-08-19
1512 In the Line of Fire: Debris Throwing by Wild Octopuses
Godfrey-Smith, P.; Scheel, D.; Chancellor, S.; Linquist, S.; Lawrence, M.
10.1101/2021.08.18.456805 — animal behavior and cognition — Posted on 2021-08-19
1518 Selection against admixture and gene regulatory divergence in a long-term primate field study
Vilgalys, T. P.; Fogel, A. S.; Mututua, R. S.; Warutere, J. K.; Siodi, L.; Anderson, J. A.; Kim, S. Y.; Voyles, T. N.; Robinson, J. A.; Wall, J. D.; Archie, E. A.; Alberts, S. C.; Tung, J.
10.1101/2021.08.19.456711 — evolutionary biology — Posted on 2021-08-19
1522 Single amino-acid mutation in the Drosophila melanogaster ribosomal protein uL11: an insight in its transcriptional activity
Grunchec, H.; Deraze, J.; Dardalhon-Cumenal, D.; Ribeiro, V.; Coleno-Costes, A.; Dias, K.; Bloyer, S.; Mouchel-Vielh, E.; Peronnet, F.; Thomassin, H.
10.1101/2021.08.18.456895 — developmental biology — Posted on 2021-08-19
1524 The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets
Chung, J.; Park, J.; Lai, Z. W.; Lambert, T. J.; Richards, R. C.; Farese, R. V.; Walther, T. C.
10.1101/2021.08.18.456894 — cell biology — Posted on 2021-08-19
1526 Virucidal activity of CPC-containing oral rinses against SARS-CoV-2 variants and are active in the presence of human saliva
Anderson, E. R.; Patterson, E. I.; Richards, S.; Green, A. K.; Mukherjee, S.; Hoptroff, M.; Hughes, G.
10.1101/2021.08.05.455040 — microbiology — Posted on 2021-08-19
1527 ACE2-Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker
Chen, Y.; Zhang, Y.; Yan, R.; Wang, G.; Zhang, Y.; Zhang, Z.; Li, Y.; ou, j.; Chu, W.; Liang, Z.; wang, y.; Chen, Y.; Chen, G.; Wang, Q.; Zhou, Q.; Zhang, B.; Wang, C.
10.1101/2020.11.11.375972 — microbiology — Posted on 2021-08-19
1531 Longitudinal immune dynamics of mild COVID-19 define signatures of recovery and persistence
Talla, A.; Vasaikar, S. V.; Lemos, M. P.; Moodie, Z.; Pebworth, M.-P. L.; Henderson, K. E.; Cohen, K. W.; Czartoski, J. L.; Lai, L.; Suthar, M. S.; Heubeck, A. T.; Genge, P. C.; Roll, C. R.; Weiss, M.; Reading, J.; Kondza, N.; MacMillan, H.; Fong, O. C.; Thomson, Z. J.; Graybuck, L. T.; Okada, L. Y.; Newell, E. W.; Coffey, E. M.; Meijer, P.; Becker, L. A.; De Rosa, S. C.; Skene, P. J.; Torgerson, T. R.; Li, X.; Szeto, G. L.; McElrath, M. J.; Bumol, T. F.
10.1101/2021.05.26.442666 — immunology — Posted on 2021-08-19
1532 TGF-β1 drives Th9 but not Treg cells upon allergen exposure
Musiol, S.; Alessandrini, F.; Jakwerth, C. A.; Chaker, A. M.; Schneider, E.; Guerth, F.; Ghiordanescu, I.; Ullmann, J. T.; Kau, J.; Plaschke, M.; Haak, S.; Buch, T.; Schmidt-Weber, C. B.; Zissler, U. M.
10.1101/2021.08.18.456797 — immunology — Posted on 2021-08-19
1534 Myostatin is a negative regulator of adult neurogenesis in zebrafish
Muraleedharan Saraswathy, V.; Zhou, L.; Burris, B.; Dogra, D.; Reischauer, S.; Mokalled, M. H.
10.1101/2021.08.18.456778 — neuroscience — Posted on 2021-08-19
1537 Ether anesthetics prevents touch-induced trigger hair calcium-electrical signals excite the Venus flytrap
Scherzer, S.; Huang, S.; Iosip, A.; Fuchs, I.; Yokawa, K.; AL-Rasheid, K. A. S.; Heckmann, M.; Hedrich, R.
10.1101/2021.08.18.456873 — plant biology — Posted on 2021-08-19
1539 Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant
Tong, J.-J.; Khan, U.; Haddad, B. G.; Minogue, P. J.; Beyer, E. C.; Berthoud, V. M.; Reichow, S. L.; Ebihara, L.
10.1101/2021.08.18.456706 — physiology — Posted on 2021-08-19
1540 Rhythmic clock gene expression in Atlantic salmon parr brain
Bolton, C.; Bekaert, M.; Eilertsen, M.; Helvik, J. V.; Migaud, H.
10.1101/2021.08.18.456820 — physiology — Posted on 2021-08-19
1541 ROS signalling requires uninterrupted electron flow and is lost during ageing in flies
Graham, C.; Stefanatos, R.; Yek, A. E. H.; Spriggs, R. V.; Loh, S. H. Y.; Huerta Uribe, A.; Zhang, T.; Martins, L. M.; Maddocks, O. D. K.; Scialo, F.; Sanz, A.
10.1101/2021.08.18.456795 — physiology — Posted on 2021-08-19
1542 Before trilobite legs: Pygmaclypeatus daziensis reconsidered and the ancestral appendicular organization of Cambrian artiopods
Schmidt, M.; Hou, X.; Zhai, D.; Mai, H.; Belojevic, J.; Chen, X.; Melzer, R. R.; Ortega-Hernandez, J.; Liu, Y.
10.1101/2021.08.18.456779 — paleontology — Posted on 2021-08-19
1543 BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU+ CAF expression with HSF1 signaling
Shaashua, L.; Pevsner-Fischer, M.; Friedman, G.; Levi-Galibov, O.; Nandakumar, S.; Nevo, R.; Brown, L. E.; Zhang, W.; Stein, Y.; Kim, H. S.; Bojmar, L.; Jarnagin, W. R.; Lecomte, N.; Stok, R.; Bishara, H.; Hamodi, R.; Levy-Lahad, E.; Golan, T.; Porco, J. A.; Iacobuzio-Donahue, C. A.; Schultz, N.; Lyden, D.; Tuveson, D.; Kelsen, D.; Scherz-Shouval, R.
10.1101/2021.08.18.456576 — cancer biology — Posted on 2021-08-19
1544 Designing and interpreting 4D tumour spheroid experiments
Murphy, R. J.; Browning, A. P.; Gunasingh, G.; Haass, N. K.; Simpson, M. J.
10.1101/2021.08.18.456910 — biophysics — Posted on 2021-08-19
1547 Rapid radiation of Southern Ocean shags in response to receding sea ice
Rawlence, N. J.; Salis, A. T.; Spencer, H. G.; Waters, J. M.; Scarsbrook, L.; Phillips, R. A.; Calderon, L.; Cook, T. R.; Bost, C.-A.; Dutoit, L.; King, T. M.; Masello, J. F.; Nupen, L. J.; Quillfeldt, P.; Ratcliffe, N.; Ryan, P. G.; Till, C. E.; Kennedy, M.
10.1101/2021.08.18.456742 — evolutionary biology — Posted on 2021-08-19
1549 Emerging harmful algal blooms caused by distinct seasonal assemblages of the toxic diatom Pseudo-nitzschia in Narragansett Bay, RI, USA
Sterling, A. R.; Kirk, R. D.; Bertin, M. J.; Rynearson, T. A.; Borkman, D. G.; Caponi, M. C.; Carney, J.; Hubbard, K. A.; King, M. A.; Maranda, L.; McDermith, E. J.; Santos, N. R.; Strock, J. P.; Tully, E. M.; Vaverka, S. B.; Wilson, P. D.; Jenkins, B. D.
10.1101/2021.08.18.456122 — ecology — Posted on 2021-08-19
1552 L-DOPA enhances hippocampal directionsignals in younger and older adults
Koch, C.; Bäuchl, C.; Glöckner, F.; Riedel, P.; Petzold, J.; Smolka, M.; Li, S.-C.; Schuck, N. W.
10.1101/2021.08.18.456677 — neuroscience — Posted on 2021-08-19
1553 Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L
Wani, G.; Sprenger, H.-G.; Ndoci, K.; Chandragiri, S.; Acton, R. J.; Schatton, D.; Kochan, S. M. V.; Sakthivelu, V.; Jevtic, M.; Seeger, J. M.; Mueller, S.; Giavalisco, P.; Rugarli, E. I.; Motori, E.; Langer, T.; Bergami, M.
10.1101/2021.08.18.456709 — neuroscience — Posted on 2021-08-19
1555 Long-term p21 and p53 trends regulate the frequency of mitosis events and cell cycle arrest
Tran, A. P.; Tralie, C. J.; Moosmüller, C.; Belkhatir, Z.; Reyes, J.; Levine, A. J.; Deasy, J. O.; Tannenbaum, A. R.
10.1101/2021.08.17.456721 — systems biology — Posted on 2021-08-19
1556 Integrated experimental-computational analysis of a liver-islet microphysiological system for human-centric diabetes research
Casas, B.; Vilen, L.; Bauer, S.; Kanebratt, K.; Wennberg Huldt, C.; Magnusson, L.; Marx, U.; Andersson, T. B.; Gennemark, P.; Cedersund, G.
10.1101/2021.08.18.456693 — systems biology — Posted on 2021-08-19
1557 Metabolomics of healthy and stony coral tissue loss disease affected Montastraea cavernosa corals
Deutsch, J. M.; Jaiyesimi, O.; Pitts, K.; Houk, J.; Ushijima, B.; Walker, B. K.; Paul, V. J.; Garg, N.
10.1101/2021.08.18.456681 — systems biology — Posted on 2021-08-19
1558 Selection for seed size has indirectly shaped specialized metabolite abundance in oat (Avena sativa L.)
Brzozowski, L. J.; Hu, H.; Campbell, M.; Broeckling, C.; Caffe-Treml, M.; Guterrez, L.; Smith, K. P.; Sorrells, M. E.; Gore, M. A.; Janninck, J.-L.
10.1101/2021.08.18.454785 — plant biology — Posted on 2021-08-19
1559 Overexpression of HOP2 induces developmental defects and compromises growth in Arabidopsis
Garrido, A. N.; Francom, T.; Divan, S.; Kesserwan, M.; Daradur, J.; Riggs, C. D.
10.1101/2021.08.17.456113 — plant biology — Posted on 2021-08-19
1561 Variation in white spruce needle respiration across the species range
Griffin, K. L.; Griffin, Z. M.; Schmiege, S. C.; Bruner, S. G.; Boelman, N. T.; Vierling, L. A.; Eitel, J. U.
10.1101/2021.08.18.456715 — plant biology — Posted on 2021-08-19
1562 Rice LEAFY COTYLEDON1 hinders photosynthesis in the embryo development to promote seed dormancy
Guo, F.; Zhang, P.; Wu, Y.; Lian, G.; Liu, W.; B, B.; Zhou, C.; Han, N.; Zhu, M.; Xu, L.; Chen, M.; Bian, H.
10.1101/2021.08.18.456739 — plant biology — Posted on 2021-08-19
1563 Metabolic and Proteomic Defects in Human Hypertrophic Cardiomyopathy
Previs, M.; O'Leary, T.; Wood, N.; Morley, M.; Palmer, B.; LeWinter, M.; Yob, J.; Pagani, F.; Petucci, C.; Kim, M. S.; Margulies, K.; Arany, Z.; Kelly, D.; Day, S.
10.1101/2021.08.18.455967 — physiology — Posted on 2021-08-19
1566 Heterogeneity of the Cancer Cell Line Metabolic Landscape
Shorthouse, D.; Bradley, J.; Critchlow, S.; Bendtsen, C.; Hall, B. A.
10.1101/2021.08.19.456093 — cancer biology — Posted on 2021-08-19
1568 AllerStat: Finding Statistically Significant Allergen-Specific Patterns in Protein Sequences by Machine Learning
Goto, K.; Tamehiro, N.; Yoshida, T.; Hanada, H.; Sakuma, T.; Adachi, R.; Kondo, K.; Takeuchi, I.
10.1101/2021.08.17.456743 — bioinformatics — Posted on 2021-08-19
1569 Fluorogenic EXO-Probe Aptamers for Imaging and Tracking Exosomal RNAs
Bonacquisti, E. E.; Ferguson, S. W.; Jasiewicz, N. E.; Wang, J.; Brown, A. D.; Keeley, D. P.; Itano, M. S.; Nguyen, J.
10.1101/2021.08.18.456703 — bioengineering — Posted on 2021-08-19
1570 Guided Axon Outgrowth of Neurons by Real-Time Femtosecond Laser Penetration on a 4 μm Thick Thin-Glass Sheet
Anggraini, D.; Liu, X.; Okano, K.; Tanaka, Y.; Inagaki, N.; Li, M.; Hosokawa, Y.; Yamada, S.; Yalikun, Y.
10.1101/2021.08.17.456633 — bioengineering — Posted on 2021-08-19
1572 Deep tissue scattering compensation with three-photon F-SHARP
Berlage, C.; Tantirigama, M. L. S.; Babot, M.; Di Battista, D.; Whitmire, C.; Papadopoulos, I.; Poulet, J. F. A.; Larkum, M.; Judkewitz, B.
10.1101/2021.08.18.456049 — bioengineering — Posted on 2021-08-19
1573 Range-wide habitat use and Key Biodiversity Area coverage for a lowland tropical forest raptor across an increasingly deforested landscape
Sutton, L. J.; Anderson, D. L.; Franco, M.; McClure, C. J.; Miranda, E. B.; Vargas, F. H.; Vargas-Gonzalez, J. d. J.; Puschendorf, R.
10.1101/2021.08.18.456651 — ecology — Posted on 2021-08-19
1574 Deep learning-based algorithm for predicting the live birth potential of mouse embryos
Tokuoka, Y.; Yamada, T. G.; Mashiko, D.; Ikeda, Z.; Kobayashi, T. J.; Yamagata, K.; Funahashi, A.
10.1101/2021.08.19.456065 — developmental biology — Posted on 2021-08-19
1575 THE TRANSCRIPTIONAL RESPONSE TO OXIDATIVE STRESS IS INDEPENDENT OF STRESS-GRANULE FORMATION
Singh, A.; Kandi, A. R.; Jayaprakashappa, D.; Thuery, G.; Purohit, D. J.; Huelsmeier, J.; Singh, R.; Pothapragada, S. S.; Ramaswami, M.; Bakthavachalu, B.
10.1101/2021.08.18.456454 — cell biology — Posted on 2021-08-19
1576 Imaging-guided fine tuning of CAR synapse dynamics and T cell triggering
Beppler, C.; Eichorst, J.; Marchuk, K.; Cai, E.; Castellanos, C. A.; Sriram, V.; Roybal, K. T.; Krummel, M. F.
10.1101/2021.08.18.456686 — immunology — Posted on 2021-08-19
1578 The Rules of Pulsatile Neurostimulation
Steinhardt, C. R.; Mitchell, D. E.; Cullen, K. E.; Fridman, G. Y.
10.1101/2021.08.18.456731 — neuroscience — Posted on 2021-08-19
1580 Trait empathy modulates music-related functional connectivity.
Moorthigari, V.; Carlson, E.; Toiviainen, P.; Vuust, P.; Brattico, E.; Alluri, V.
10.1101/2021.08.18.456484 — neuroscience — Posted on 2021-08-19
1581 Deep Bayesian networks for uncertainty estimation and adversarial resistance of white matter hyperintensity segmentation
Mojiri Forooshani, P.; Biparva, M.; Ntiri, E. E.; Ramirez, J.; Boone, L.; Holmes, M. F.; Adamo, S.; Gao, F.; Ozzoude, M.; Scott, C. J. M.; Dowlatshahi, D.; Lawrence-Dewar, J. M.; Kwan, D.; Lang, A. E.; Marcotte, K.; Leonard, c.; Rochon, E.; Heyn, C.; Bartha, R.; Strother, S.; Tardif, J.-C.; Symons, S.; Masellis, M.; Swartz, R. H.; Moody, A.; Black, S. E.; Goubran, M.
10.1101/2021.08.18.456666 — neuroscience — Posted on 2021-08-19
1584 Macrophages in the reticuloendothelial system inhibit the propagation phase of mouse apolipoprotein A-II amyloidosis
Miyahara, H.; Dai, J.; Li, Y.; Xiaoran, C.; Takeuchi, H.; Hachiya, N.; Kametani, F.; Yazaki, M.; Mori, M.; Higuchi, K.
10.1101/2021.08.18.456782 — molecular biology — Posted on 2021-08-19
1585 SIGNR1 promotes immune dysfunction in systemic candidiasis by modulating neutrophil lifespan via T cell-derived histones and G-CSF
Ioannou, M.; Hoving, D.; Aramburu, I. V.; De Vasconcelos, N. M.; Temkin, M. I.; Wang, Q.; Vernardis, S.; Demichev, V.; Tsourouktsoglou, T.-D.; Boeing, S.; Goldstone, R.; David, S.; Klaus Stahl, K.; Bode, C.; Ralser, M.; Papagiannopoulos, V.
10.1101/2021.08.09.455510 — immunology — Posted on 2021-08-19
1587 Python-Microscope: A new open source Python library for the control of microscopes
Susano Pinto, D. M. M. S.; Phillips, M. A.; Hall, N.; Mateos-Langerak, J.; Stoychev, D.; Pinto, T. S.; Booth, M. J.; Davis, I.; Dobbie, I. M.
10.1101/2021.01.18.427171 — biophysics — Posted on 2021-08-19
1588 Tension mediated mechanical activation and pocket delipidation lead to an analogous MscL state
Wang, B.; Lane, B. J.; Kapsalis, C.; Ault, J. R.; Sobott, F.; El Mkami, H.; Calabrese, A. N.; Kalli, A. C.; Pliotas, C.
10.1101/2021.04.01.438050 — biophysics — Posted on 2021-08-19
1591 Translational control as a novel regulator of gradient sensing and chemotropism in yeast
Gelin-Licht, R.; Conlon, P. J.; Singh, R.; Haimovich, G.; Baez, C.; Gal, L.; Schuldiner, M.; Levchenko, A.; Gerst, J. E.
10.1101/2020.12.13.422562 — cell biology — Posted on 2021-08-19
1592 Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular S. Typhimurium
Cohen, H.; Hoede, C.; Scharte, F.; Coluzzi, C.; Cohen, E.; Shomer, I.; Mallet, L.; Serre, R. F.; Schiex, T.; Virlogeux-Payant, I.; Grassl, G.; Hensel, M.; Chiapello, H.; Gal-Mor, O.
10.1101/2021.08.18.456644 — microbiology — Posted on 2021-08-19
1593 Cyclin-G-associated kinase GAK/Aux orchestrates glial autophagy via Atg9 phosphorylation in Parkinson's disease
Zhang, S.; Wang, L.; Yi, S.; Li, S.; Wang, H.; Song, L.; Ou, J.; Zhang, M.; Wang, M.; Zheng, Y.; Wang, R.; Yang, K.; Liu, T.; Yan, W.; Liu, C.; Ho, M.
10.1101/2021.08.16.456579 — neuroscience — Posted on 2021-08-19
1594 Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease
Viard, J.; Loe-Mie, Y.; Khelfaoui, M.; Daudin, R.; Plancon, C.; Boland, A.; Tejedor, F.; Huganir, R.; Kim, E.; Kinoshita, M.; Liu, G.; Haucke, V.; Moncion, T.; Yu, E.; Hindie, V.; Blehaut, H.; Mircher, C.; Herault, Y.; Deleuze, J.-F.; Rain, J.-C.; Simonneau, M.; Lepagnol-Bestel, A.-M.
10.1101/2019.12.11.872606 — neuroscience — Posted on 2021-08-19
1599 IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity
Lang, R.; Wirtz, S.; Voehringer, D.; Lacorcia, M.; Altunay, M.; Bodendorfer, B.; Schubart, C.; Christensen, D.; Alexander, C.; Schick, J.; da Costa, C. P.
10.1101/2021.08.17.456702 — immunology — Posted on 2021-08-19
1601 scFlow: A Scalable and Reproducible Analysis Pipeline for Single-Cell RNA Sequencing Data
Khozoie, C.; Fancy, N.; Marjaneh, M. M.; Murphy, A. E.; Matthews, P. M.; Skene, N.
10.1101/2021.08.16.456499 — bioinformatics — Posted on 2021-08-19
1602 Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams-Beuren syndrome
Navarro-Romero, A.; Galera-Lopez, L.; Ortiz-Romero, P.; Llorente-Ovejero, A.; de los Reyes-Ramirez, L.; Mas-Stachurska, A.; Reixachs-Sole, M.; Pastor, A.; de la Torre, R.; Maldonado, R.; Benito, B.; Eyras, E.; Rodriguez-Puertas, R.; Campuzano, V.; Ozaita, A.
10.1101/2021.08.16.456474 — animal behavior and cognition — Posted on 2021-08-19
1607 Evolutionary analysis of the LORELEI gene family in angiosperms reveals regulatory subfunctionalization
Noble, J. A.; Bielski, N. V.; Liu, M.-C. J.; DeFalco, T. A.; Stegmann, M.; Nelson, A. D. L.; McNamara, K.; Sullivan, B.; Dinh, K. K.; Khuu, N.; Hancock, S.; Shiu, S.-H.; Zipfel, C.; Beilstein, M. A.; Cheung, A. Y.; Palanivelu, R.
10.1101/2020.04.27.062893 — plant biology — Posted on 2021-08-19
1609 Phylogenetic analysis of molecular pathways in Tregs Suppressor Function
Mickael, M. E.; Kubick, N.; Bhaumik, S.; Horbanczuk, J. O.; Sacharczuk, M.; Basu, R.
10.1101/2021.07.30.453759 — evolutionary biology — Posted on 2021-08-19
1610 Does plant diversity determine the diversity of the rhizosphere microbial community?
Zverev, A.; Kichko, A.; Shapkin, V.; Pinaev, A.; Provorov, N.; Andronov, E.
10.1101/2021.08.18.456889 — microbiology — Posted on 2021-08-19
1611 Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs
MANCEAU, L.; RICHARD ALBERT, J.; LOLLINI, P.-L.; GREENBERG, M. V. C.; GILARDI-HEBENSTREIT, P.; Ribes, V.
10.1101/2021.08.18.456823 — cancer biology — Posted on 2021-08-18
1619 Does plant diversity determine the diversity of the rhizosphere microbial community?
Zverev, A.; Kichko, A.; Shapkin, V.; Pinaev, A.; Provorov, N.; Andronov, E.
10.1101/2021.08.18.456890 — microbiology — Posted on 2021-08-18
1621 Goal-oriented predictive representations in the human hippocampus
Crivelli-Decker, J.; Clarke, A.; Park, S.; Huffman, D.; Boorman, E.; Ranganath, C.
10.1101/2021.08.18.456881 — neuroscience — Posted on 2021-08-18
1622 Prediction Under Uncertainty: Dissociating Sensory from Cognitive Expectations in Highly Uncertain Musical Contexts
Mencke, I.; Quiroga-Martinez, D. R.; Omigie, D.; Schwarzacher, F.; Haumann, N. T.; Michalareas, G.; Vuust, P.; Brattico, E.
10.1101/2021.08.18.456640 — neuroscience — Posted on 2021-08-18
1623 Sarcoptic mange outbreak decimates South American camelid populations in San Guillermo National Park, Argentina
Ferreyra, H. d. V.; Rudd, J.; Foley, J.; Vanstreels, R. E. T.; Martin, A. M.; Donadio, E.; Uhart, M. M.
10.1101/2021.08.18.456827 — zoology — Posted on 2021-08-18
1626 SpatialExperiment: infrastructure for spatially resolved transcriptomics data in R using Bioconductor
Righelli, D.; Weber, L. M.; Crowell, H. L.; Pardo, B.; Collado-Torres, L.; Ghazanfar, S.; Lun, A. T.; Hicks, S. C.; Risso, D.
10.1101/2021.01.27.428431 — bioinformatics — Posted on 2021-08-18
1628 Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2
Sangree, A. K.; Griffith, A. L.; Szegletesh, Z. M.; Roy, P.; DeWeirdt, P. C.; Hegde, M.; McGee, A. V.; Hanna, R. E.; Doench, J. G.
10.1101/2021.08.18.456848 — genomics — Posted on 2021-08-18
1629 Interior of sand fly (Diptera: Psychodidae) abdomen reveals novel structures involved in pheromone release: discovering the Manifold.
Tonelli, G. B.; Andrade-Filho, J. D.; Campos, A. M.; Margonari, C.; Amaral, A. R.; Volf, P.; Shaw, E. J.; Hamilton, J. G. C.
10.1101/2021.08.18.456824 — ecology — Posted on 2021-08-18
1630 Using expert-elicitation to deliver biodiversity monitoring priorities on a Mediterranean island
Peyton, J.; Hadjistylli, M.; Tziortzis, I.; Erotokritou, E.; Demetriou, M.; Samuel-Rhoads, Y.; Anastasi, V.; Fyttis, G.; Hadjioannou, L.; Ieronymidou, C.; Kassinis, N.; Kleitou, P.; Kletou, D.; Mandoulaki, A.; Michailidis, N.; Papatheodoulou, A.; Payiattas, G.; Sparrow, D.; Sparrow, R.; Turvey, K.; Tzirkalli, E.; Varnava, A. I.; Pescott, O. L.
10.1101/2021.08.18.456866 — ecology — Posted on 2021-08-18
1631 Flexible pri-miRNA structures enable tunable production of 5' isomiRs
Bofill-De Ros, X.; Hong, Z.; Birkenfeld, B.; Alamo-Ortiz, S.; Yang, A.; Dai, L.; Gu, S.
10.1101/2021.08.18.456839 — molecular biology — Posted on 2021-08-18
1633 The IgE production is initially induced in subcutaneous fat and depends on extrafollicular B cells
Chudakov, D. B.; Fattakhova, G. V.; Konovalova, M. V.; Tsaregorotseva, D. S.; Shevchenko, M. A.; Kotsareva, O. D.; Sergeev, A. A.; Svirshchevskaya, E. V.
10.1101/2021.08.18.456888 — immunology — Posted on 2021-08-18
1634 SIGNR1 promotes immune dysfunction in systemic candidiasis by modulating neutrophil lifespan via T cell-derived histones and G-CSF
Ioannou, M.; Hoving, D.; Aramburu, I. V.; De Vasconcelos, N. M.; Temkin, M. I.; Wang, Q.; Vernardis, S.; Demichev, V.; Tsourouktsoglou, T.-D.; Boeing, S.; Goldstone, R.; David, S.; Klaus Stahl, K.; Bode, C.; Ralser, M.; Papagiannopoulos, V.
10.1101/2021.08.09.455510 — immunology — Posted on 2021-08-18
1635 Spatial and Temporal Consistency of Brain Networks for different Multi-Echo fMRI Combination Methods
Pilmeyer, J.; Hadjigeorgiou, G.; Lamerichs, R.; Breeuwer, M.; Aldenkamp, B.; Zinger, S.
10.1101/2021.08.18.456877 — neuroscience — Posted on 2021-08-18
1636 Lowering the Thermal Noise Barrier in Functional Brain Mapping with Magnetic Resonance Imaging
Vizioli, L.; Moeller, S.; Dowdle, L.; Akcakaya, M.; De Martino, F.; Yacoub, E.; Ugurbil, K.
10.1101/2020.11.04.368357 — neuroscience — Posted on 2021-08-18
1638 DARQ: Deep learning of quality control for stereotaxic registration of human brain MRI
Fonov, V.; Dadar, M.; The PREVENT-AD Research Group, ; ADNI, ; Collins, D. L.
10.1101/2021.08.16.456514 — neuroscience — Posted on 2021-08-18
1639 Sharks, Lies, and Videotape: A content analysis of 32 years of Shark Week documentaries
Whitenack, L. B.; Mickley, B. L.; Saltzman, J.; Kajiura, S. M.; Macdonald, C. C.; Shiffman, D. S.
10.1101/2021.08.18.456878 — scientific communication and education — Posted on 2021-08-18
1640 Utilizing Digital Pathology to Quantify Stromal Caveolin-1 Expression in Malignant and Benign Ovarian Tumors: Associations with Clinicopathological Parameters and Clinical Outcomes
Saeed-Vafa, D.; Marchion, D. C.; McCarthy, S. M.; Hakam, A.; Lopez, A.; Wenham, R. M.; Apte, S. M.; Chen, D.-T.; Magliocco, A. M.; Lancaster, J. M.; Reid, B. M.; Permuth, J. B.
10.1101/2021.08.18.456818 — cancer biology — Posted on 2021-08-18
1642 SOX2-phosphorylation toggles a bistable differentiation-switch in squamous cell carcinoma
Hoang-Phou, S.; Sastre-Perona, A.; Abbruzzese, M.; Ying, Z.; Siegle, J.; Aranda Orgilles, B.; Rocha, P. P.; Aifantis, I.; Skok, J.; Beronja, S.; Schober, M.
10.1101/2021.08.18.455699 — cancer biology — Posted on 2021-08-18
1644 Physicochemical and Pharmacokinetic Properties Determining Drug Detection in Skin
Bittremieux, W.; Advani, R.; Jarmusch, A. K.; Aguirre, S.; Lu, A.; Dorrestein, P. C.; Tsunoda, S. M.
10.1101/2021.08.17.456720 — bioinformatics — Posted on 2021-08-18
1645 A Robust, Low-Cost Instrument for Real-time Colorimetric Isothermal Nucleic Acid Amplification
Myers, F.; Moffatt, B.; El Khaja, R.; Chatterjee, T.; Marwaha, G.; McGee, M.; Mitra, D.
10.1101/2021.08.18.456885 — bioengineering — Posted on 2021-08-18
1646 In vivo hemostatic capability of a novel Tetra-PEG hydrogel
Okata, S.; Hoshina, K.; Hanada, K.; Kamata, H.; Fujisawa, A.; Yoshikawa, Y.; Sakai, T.
10.1101/2021.08.18.456884 — bioengineering — Posted on 2021-08-18
1648 Genetic Analysis of Bphse: a Novel Gene Complementing Resistance to Bordetella pertussis-Induced Histamine Sensitization
Teuscher, C.; Raza, A.; Diehl, S. A.; Case, L. K.; Krementsov, D. N.; Li, D.; Kost, J.; Ball, R. L.; Chesler, E. J.; Philip, V. M.; Huang, R.; Chen, Y.; Ma, R.; Tyler, A. L.; Mahoney, J. M.; Blankenhorn, E. P.
10.1101/2021.08.18.456822 — genetics — Posted on 2021-08-18
1649 Direct reprogramming of human embryonic to trophoblast stem cells
Fogarty, N. M.; Abdelbaki, A.; McCarthy, A.; Devito, L.; Chen, A. E.; Munusamy, P.; Blakeley, P.; Elder, K.; Snell, P.; Christie, L.; Serhal, P.; Odia, R. A.; Sangrithi, M.; Niakan, K. K.
10.1101/2021.08.18.456785 — developmental biology — Posted on 2021-08-18
1650 The PAF1 complex cell-autonomously promotes oogenesis in Caenorhabditis elegans
Kubota, Y.; Ota, N.; Takatsuka, H.; Unno, T.; Onami, S.; Sugimoto, A.; ito, M.
10.1101/2021.08.18.456829 — developmental biology — Posted on 2021-08-18
1652 Cap-independent translation and a precisely localized RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral response
Slobodin, B.; Sehrawat, U.; Lev, A.; Ogran, A.; Fraticelli, D.; Hayat, D.; Zuckerman, B.; Ulitsky, I.; Ben-Shmuel, A.; Levy, H.; Bar-David, E.; Dikstein, R.
10.1101/2021.08.18.456855 — molecular biology — Posted on 2021-08-18
1653 New insights into antimalarial chemopreventive activity of antifolates
Pethrak, C.; Posayapisit, N.; Pengon, J.; Suwanakitti, N.; Saeung, A.; Shorum, M.; Aupalee, K.; Taai, K.; Yuthavong, Y.; Kamchonwongpaisan, S.; Jupatanakul, N.
10.1101/2021.08.17.456746 — microbiology — Posted on 2021-08-18
1655 CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapies
Hwang, J. H.; Arafeh, R.; Seo, J.-H.; Baca, S. C.; Ludwig, M.; Arnoff, T. E.; Richter, C.; Bergom, H. E.; McSweeney, S.; Rennhack, J. P.; Klingenberg, S. A.; Cheung, A. T.; Kwon, J.; So, J.; Kregel, S.; Van Allen, E.; Drake, J. M.; Freedman, M. L.; Hahn, W.
10.1101/2021.08.18.456892 — cancer biology — Posted on 2021-08-18
1656 Mechanics of live cell elimination
Monfared, S.; Ravichandran, G.; Andrade, J. E.; Doostmohammadi, A.
10.1101/2021.08.17.456649 — biophysics — Posted on 2021-08-18
1658 DNA Origami Voltage Sensors for Transmembrane Potentials with Single-Molecule Sensitivity
Ochmann, S. E.; Joshi, H.; Bueber, E.; Franquelim, H. G.; Stegemann, P.; Sacca, B.; Keyser, U. F.; Aksimentiev, A.; Tinnefeld, P.
10.1101/2021.08.18.456762 — biophysics — Posted on 2021-08-18
1659 STonKGs: A Sophisticated Transformer Trained on Biomedical Text and Knowledge Graphs
Balabin, H.; Hoyt, C. T.; Birkenbihl, C.; Gyori, B. M.; Bachman, J. A.; Tom Kodamullil, A.; Ploeger, P. G.; Hofmann-Apitius, M.; Domingo-Fernandez, D.
10.1101/2021.08.17.456616 — bioinformatics — Posted on 2021-08-18
1660 Spatially Patterned Bi-electrode Epiretinal Stimulation for Axon Avoidance at Cellular Resolution
Vilkhu, R. S.; Madugula, S. S.; Grosberg, L. E.; Gogliettino, A. R.; Hottowy, P.; Dabrowski, W.; Sher, A.; Litke, A. M.; Mitra, S.; Chichilnisky, E. J.
10.1101/2021.08.17.454395 — bioengineering — Posted on 2021-08-18
1662 Age-related Immune-Stromal Networks Inhibit Response to Regenerative Immunotherapies
Han, J.; Cherry, C.; Ruta, A.; Maestas, D. R.; Mejias, J. C.; Nguyen, H. H.; Fertig, E. J.; Housseau, F.; Ganguly, S.; Moore, E.; Tam, A. J.; Pardoll, D. M.; Elisseeff, J. H.
10.1101/2021.08.17.456641 — bioengineering — Posted on 2021-08-18
1663 Implications of critical nodes-dependent unidirectional cross-talk between Plasmodium and Human SUMO
Mishra, R. K.; Singh, J. S.; T K, S.; Panigrahi, R.; Cherry, P.; Panchakshari, N. A.; Shukla, V. K.; kumar, A.
10.1101/2021.08.18.456755 — biochemistry — Posted on 2021-08-18
1669 Monitoring fish communities through DNA metabarcoding in the fish pass system of the second largest hydropower plant in the world
Dal Pont, G.; Ritter, C. D.; Olivotto Agostinis, A.; Valeska Stika, P.; Horodesky, A.; Cozer, N.; Balsanelli, E.; Mader Netto, O. S.; Henn, C.; Ostrensky, A.; Pie, M. R.
10.1101/2021.08.17.456687 — ecology — Posted on 2021-08-18
1671 A mitotic screen in Indian muntjac cells unveils how Augmin drives kinetochore fiber maturation
Almeida, A. C.; Oliveira, J.; Drpic, D.; Cheeseman, L.; Damas, J.; Lewin, H. A.; Larkin, D.; Aguiar, P.; Pereira, A. J.; Maiato, H.
10.1101/2021.08.18.456780 — cell biology — Posted on 2021-08-18
1673 Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs
Sun, Y. H.; Wang, R. H.; Du, K.; Zheng, J.; Xie, L. H.; Pereira, A. A.; Zhang, C.; Ricci, E. P.; Li, X. Z.
10.1101/2021.07.10.451906 — molecular biology — Posted on 2021-08-18
1674 Horizontal transfer of a conserved npc-2 like effector gene in rust fungi that suppresses cell death in plants
Jaswal, R.; Dubey, H.; Kiran, K.; Rawal, H.; Kumar, G.; Rajarammohan, S.; Deshmukh, R.; Sonah, H.; Prasad, P.; Bhardwaj, S. C.; Gupta, N.; Sharma, T.
10.1101/2021.08.18.456830 — microbiology — Posted on 2021-08-18
1676 Single-cell lineage trajectories and chromatin regulators that initialize antiviral CD8 T cell ontogeny
Diao, H.; Chen, R.; Tsuda, S. M.; Wang, D.; Frederick, M. A.; Kim, J.; Karunadharma, P. P.; Martinez, G. J.; Getzler, A. J.; Toma, C.; Milner, J. J.; Venables, T. C.; Martin, D. M.; Goldrath, A. W.; Crotty, S.; Pipkin, M. E.
10.1101/2021.08.11.456014 — immunology — Posted on 2021-08-18
1677 Type I interferon modulates Langerhans cell ADAM17 to promote photosensitivity in lupus
Li, T. M.; Veiga, K. R.; Schwartz, N.; Chinenov, Y.; Oliver, D. J.; Lora, J.; Jabbari, A.; Liu, Y.; Shipman, W. D.; Sandoval, M. J.; Sollohub, I. F.; Ambler, W. G.; Rashighi, M.; Krueger, J. G.; Anandasabapathy, N.; Blobel, C. P.; Lu, T. T.
10.1101/2021.08.18.456792 — immunology — Posted on 2021-08-18
1678 CRISPR activation screening identifies VGLL3 and GATA2 as transcriptional regulators of PD-L1
Wijdeven, R. H.; Cabukusta, B.; Qiu, X.; Borras, D. M.; Liang, Y.; Neefjes, J. J.
10.1101/2021.08.18.456771 — immunology — Posted on 2021-08-18
1679 Neural-specific alterations in glycosphingolipid biosynthesis and cell signaling associated with two human ganglioside GM3 Synthase Deficiency variants
Dookwah, M.; Wagner, S. K.; Ishihara, M.; Yu, S.-h.; Ulrichs, H.; Kulik, M. J.; Zeltner, N.; Dalton, S.; Strauss, K. A.; Aoki, K.; Steet, R.; Tiemeyer, M.
10.1101/2021.07.29.454399 — neuroscience — Posted on 2021-08-18
1683 A tool for federated training of segmentation models on whole slide images.
Lutnick, B. R.; Manthey, D.; Becker, J. U.; Zuckerman, J. E.; Rodrigues, L.; Jen, K. Y.; Sarder, P.
10.1101/2021.08.17.456679 — pathology — Posted on 2021-08-18
1684 Development of a Reproducible Porcine Model of Infected Burn Wounds
Said, S. A.-d.; Jatana, S.; Ponti, A. K.; Johnson, E. E.; Such, K. A.; Zangara, M. T.; Madajka, M.; Papay, F.; McDonald, C.
10.1101/2021.08.16.456568 — pathology — Posted on 2021-08-18
1685 Python-Microscope: A new open source Python library for the control of microscopes
Susano Pinto, D. M. M. S.; Phillips, M. A.; Hall, N.; Mateos-Langerak, J.; Stoychev, D.; Pinto, T. S.; Booth, M. J.; Davis, I.; Dobbie, I. M.
10.1101/2021.01.18.427171 — biophysics — Posted on 2021-08-18
1687 ORC binds and remodels nucleosomes to specify MCM loading onto DNA
Li, S.; Wasserman, M. R.; Yurieva, O.; Bai, L.; O'Donnell, M. E.; Liu, S.
10.1101/2021.08.17.456647 — biophysics — Posted on 2021-08-18
1690 wnt16 exerts pleiotropic effects on bone and lean mass in zebrafish
Watson, C. J.; Morfin Montes de Oca, E.; Fiedler, I. A. K.; Cronrath, A. R.; Callies, L. K.; Swearer, A. A.; Sethuraman, V.; Ahmed, A. R.; Monstad-Rios, A. T.; Rojas, M. F.; Tang, W. J.; Gardiner, E. M.; Busse, B.; Hsu, Y.-H.; Kwon, R. Y.
10.1101/2021.08.12.456120 — genetics — Posted on 2021-08-18
1693 Systems-wide Analysis Revealed Shared and Unique Responses to Moderate and Acute High Temperatures in the Green Alga Chlamydomonas reinhardtii
Zhang, N.; Mattoon, E. M.; McHargue, W.; Venn, B.; Zimmer, D.; Pecani, K.; Jeong, J.; Anderson, C. M.; Chen, C.; Berry, J. C.; Xia, M.; Tzeng, S.-C.; Becker, E.; Pazouki, L.; Evans, B.; Cross, F.; Cheng, J.; Czymmek, K. J.; Schroda, M.; Muhlhaus, T.; Zhang, R.
10.1101/2021.08.17.456552 — cell biology — Posted on 2021-08-18
1694 Nuclear Translocation of Vitellogenin in the Honey Bee (Apis mellifera)
Salmela, H.; Harwood, G.; Munch, D.; Elsik, C. G.; Herrero-Galan, E.; Vartiainen, M. K.; Amdam, G.
10.1101/2021.08.18.456851 — molecular biology — Posted on 2021-08-18
1695 Insights into the nutritional properties and microbiome diversity in sweet and sour yogurt manufactured in Bangladesh
Islam, S. M. R.; Tanzina, A. Y.; Foysal, M. J.; Hoque, M. N.; SIDDIKI, A. Z.; Tay, A.; Hossain, S. M. J.; Bakar, M. A.; Mostafa, M.; Rumi, M. H.; Mannan, A.
10.1101/2021.08.15.456382 — microbiology — Posted on 2021-08-18
1697 Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular S. Typhimurium
Cohen, H.; Hoede, C.; Scharte, F.; Coluzzi, C.; Cohen, E.; Shomer, I.; Mallet, L.; Serre, R. F.; Schiex, T.; Virlogeux-Payant, I.; Grassl, G.; Hensel, M.; Chiapello, H.; Gal-Mor, O.
10.1101/2021.08.18.456644 — microbiology — Posted on 2021-08-18
1698 Comparative secretomics identifies conserved WAxR motif-containing effectors in rust fungi that suppress cell death in plants
Jaswal, R.; Dubey, H.; Kiran, K.; Rawal, H.; Rajarammohan, S.; Prasad, P.; Bhardwaj, S. C.; Sonah, H.; Deshmukh, R.; Gupta, N.; Sharma, T. R.
10.1101/2021.08.18.456800 — microbiology — Posted on 2021-08-18
1699 Protein-based RBD-C-tag COVID-19 Vaccination Candidate Elicits Protection Activity against SARS-COV-2 Variant Infection
Herrmann, A.; Subramani, J.; Shaabani, N.; Shetty, D.; Wu, H.; Kwon, S.; Li, W.; Yue, C.; Lahtz, C.; Ramirez-Torres, A.; Zhou, H.; Zhang, Y.; Allen, R. D.; Farley, B.; Emalfarb, M.; Tchelet, R.; Markku, S.; Marika, V.; Wiebe, M.; Huuskonen, A.; Ben-artzi, H.; Avigdor, A.; Ji, H.
10.1101/2021.08.17.456704 — microbiology — Posted on 2021-08-18
1700 Microbial loop of Proterozoic ocean analogue
Saini, J. S.; Hassler, C.; Cable, R.; Fourquez, M.; Danza, F.; Roman, S.; Tonolla, M.; Storelli, N.; Jacquet, S.; Zdobnov, E. M.; Duhaime, M. B.
10.1101/2021.08.17.456685 — microbiology — Posted on 2021-08-18
1701 An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells
Broadbent, L.; Bamford, C. G. G.; Lopez Campos, G.; Manzoor, S.; Courtney, D.; Ali, A.; Touzelet, O.; McCaughey, C.; Mills, K.; Power, U.
10.1101/2021.08.17.456707 — immunology — Posted on 2021-08-18
1702 Systemic IgG repertoire as a biomarker for translocating gut microbiota members
Vujkovic-Cvijin, I.; Welles, H.; Ha, C. W. Y.; Huq, L.; Mistry, S.; Brenchley, J. M.; Trinchieri, G.; Devkota, S.; Belkaid, Y.
10.1101/2021.08.17.456549 — immunology — Posted on 2021-08-18
1704 Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging
Wang, C.; Martins-Bach, A. B.; Alfaro-Almagro, F.; Douaud, G.; Klein, J. C.; Llera, A.; Fiscone, C.; Bowtell, R.; Elliott, L. T.; Smith, S. M.; Tendler, B. C.; Miller, K. L.
10.1101/2021.06.28.450248 — neuroscience — Posted on 2021-08-18
1705 Visual recognition of social signals by a tecto-thalamic neural circuit
Kappel, J. M.; Slangewal, K.; Foerster, D.; Shainer, I.; Svara, F.; Januszewski, M.; Sherman, S.; Baier, H.; Larsch, J.
10.1101/2021.08.17.456614 — neuroscience — Posted on 2021-08-18
1711 Bridge Category Models: Development of Bayesian Modelling Procedures to Account for Bridge Ordinal Ratings for Disease Staging
Levy, J.; Bobak, C. A.; Azizgolshani, N.; Andersen, M. J.; Suriawinata, A.; Liu, X.; Lisovsky, M.; Ren, B.; Christensen, B.; Vaickus, L.; O'Malley, J.
10.1101/2021.08.17.456726 — pathology — Posted on 2021-08-18
1712 Features of peptide fragmentation spectra in single cell proteomics
Boekweg, H.; Van Der Watt, D.; Truong, T.; Guise, A. J.; Plowey, E. D.; Kelly, R. T.; Payne, S. H.
10.1101/2021.08.17.456675 — bioinformatics — Posted on 2021-08-18
1713 Benchmarking PSM identification tools for single cell proteomics
Van Der Watt, D.; Boekweg, H.; Truong, T.; Guise, A. J.; Plowey, E. D.; Kelly, R. T.; Payne, S. H.
10.1101/2021.08.17.456676 — bioinformatics — Posted on 2021-08-18
1715 Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages
Kriplani, N.; Clohisey, S. M. R.; Fonseca, S.; Fletcher, S.; Lee, H.-M.; Ashworth, J.; Kurian, D.; Lycett, S. J.; Tait-Burkard, C.; Baillie, J. K.; Woolhouse, M. E. J.; Carding, S. R.; Stewart, J. P.; Digard, P.
10.1101/2021.08.13.456266 — microbiology — Posted on 2021-08-18
1718 Automatic wound detection and size estimation using deep learning algorithms
Carrion, H.; Jafari, M.; Bagood, M. D.; Yang, H.-y.; Isseroff, R. R.; Gomez, M.
10.1101/2020.11.13.275917 — bioinformatics — Posted on 2021-08-18
1719 Genome sequencing of 196 Treponema pallidum strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar
Lieberman, N. A.; Lin, M. J.; Xie, H.; Shretha, L.; Nguyen, T.; Huang, M.-L.; Haynes, A. M.; Romeis, E.; Wang, Q.-Q.; Zhang, R.-L.; Kou, C.-X.; Ciccarese, G.; Dal Conte, I.; Cusini, M.; Drago, F.; Nakayama, S.-i.; Lee, K.; Ohnishi, M.; Konda, K. A.; Vargas, S. K.; Eguiluz, M.; Caceres, C.; Klausner, J. D.; Mitja, O.; Rompalo, A.; Mulcahy, F.; Hook, E. W.; Lukehart, S.; Casto, A. M.; Roychoudhury, P.; DiMaio, F.; Giacani, L.; Greninger, A. L.
10.1101/2021.08.17.456619 — genomics — Posted on 2021-08-18
1721 A gene regulatory network for neural induction
Trevers, K. E.; Lu, H.-C.; Yang, Y.; Thiery, A.; Strobl, A. C.; Palinkasova, B.; de Oliveira, N. M. M.; de Almeida, I. M.; Khan, M. A. F.; Moncaut, N.; Luscombe, N. M.; Dale, L.; Streit, A.; Stern, C. D.
10.1101/2021.04.16.440164 — developmental biology — Posted on 2021-08-18
1722 A genomic perspective on genome size distribution across Earth's microbiomes reveals a tendency to gene loss
Rodriguez-Gijon, A.; Nuy, J. K.; Mehrshad, M.; Buck, M.; Schulz, F.; Woyke, T.; Garcia, S. L.
10.1101/2021.01.18.427069 — microbiology — Posted on 2021-08-18
1725 A phospho-regulated ensemble signal motif of α-TAT1 drives dynamic microtubule acetylation
Deb Roy, A.; Gross, E.; Pillai, G.; Seetharaman, S.; Etienne-Manneville, S.; Inoue, T.
10.1101/2020.09.23.310235 — cell biology — Posted on 2021-08-18
1728 Primate-specific cis- and trans-regulators shape transcriptional networks during human development
Pontis, J.; Trono, D.; Pulver, C.; Planet, E.; Grun, D.; Offner, S.; Duc, J.; Manfrin, A.; Lutolf, M. P.
10.1101/2021.08.18.456764 — evolutionary biology — Posted on 2021-08-18
1729 Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a novel cost-benefit foraging task
Bloem, B.; Huda, R.; Amemori, K.-i.; Abate, A.; Krishna, G.; Wilson, A.; Carter, C. W.; Sur, M.; Graybiel, A. M.
10.1101/2021.08.17.456542 — neuroscience — Posted on 2021-08-18
1730 Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizer
Nekounam, H.; Dinarvand, R.; Khademi, R.; Mahmoodi, N.; Arzani, H.; Hasanzadeh, E.; Karimi, R.; Kamali, M.; Khosravani, M.
10.1101/2021.05.15.444280 — cancer biology — Posted on 2021-08-18
1731 Measuring mitochondrial electron transfer complexes in previously frozen cardiac tissue from the offspring of sow: A model to assess exercise-induced mitochondrial bioenergetics changes
Barrera, D.; Upton, S.; Rauch, M.; Notarianni, T.; Eum, K. S.; Liberty, M.; Sah, S. V.; Liu, R.; Newcomer, S.; May, L. E.; Agbas, E.; Sage, J.; Kosa, E.; Agbas, A.
10.1101/2021.06.08.447578 — biochemistry — Posted on 2021-08-18
1732 In vitro determination of inhibitory effects by humic substances complexing Zn and Se on SARS-CoV-2 virus replication
Hajdrik, P.; Palyi, B.; Kis, Z.; Kovacs, N. S.; Veres, D. S.; Szigeti, K.; Hegedus, I.; Kovacs, T. J.; Bergmann, R. K.; Mathe, D.
10.1101/2021.08.11.456012 — microbiology — Posted on 2021-08-18
1735 SALARECON connects the Atlantic salmon genome to growth and feed efficiency
Zakhartsev, M.; Rotnes, F.; Gulla, M.; Oyas, O.; van Dam, J. C. J.; Suarez-Diez, M.; Grammes, F.; Hafthorsson, R. A.; van Helvoirt, W.; Koehorst, J. J.; Schaap, P. J.; Jin, Y.; Mydland, L. T.; Gjuvsland, A. B.; Sandve, S. R.; Martins dos Santos, V. A. .P.; Vik, J. O.
10.1101/2021.06.03.446971 — systems biology — Posted on 2021-08-18
1736 The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection
McDonald, J. T.; Enguita, F. J.; Taylor, D.; Griffin, R. J.; Priebe, W.; Emmett, M. R.; Sajadi, M.; Harris, A. D.; Clement, J.; Dybas, J. M.; Aykin-Burns, N.; Guarnieri, J. W.; Singh, L. N.; Grabham, P.; Baylin, S.; Yousey, A.; Pearson, A. N.; Corry, P. M.; Saravia-Butler, A.; Aunins, T. R.; Sharma, S.; Nagpal, P.; Meydan, C.; Foox, J.; Mozsary, C.; Cerqueira, B.; Zaksas, V.; Singh, U.; Wurtele, E. S.; Costes, S. V.; Davanzo, G. G.; Galeano, D.; Paccanaro, A.; Meinig, S. L.; Hagan, R. S.; Bowman, N. M.; UNC COVID-19 Pathobiology Consortium, ; Wolfgang, M. C.; Altinok, S.; Sapoval, N.; Treange
10.1101/2021.04.23.441024 — systems biology — Posted on 2021-08-18
1740 Profiling of open chromatin in developing pig (Sus scrofa) muscle to identify regulatory regions
Salavati, M.; Woolley, S. A.; Cortes Araya, Y.; Halstead, M. M.; Stenhouse, C.; Johnsson, M.; Ashworth, C. J.; Archibald, A. L.; Donadeu, F. X.; Hassan, M. A.; Clark, E. L.
10.1101/2021.01.21.426812 — genomics — Posted on 2021-08-18
1741 Dynamics of SARS-CoV-2 mutations reveals regional-specificity and similar trends of N501 and High-Frequency mutation N501Y in different levels of control measures
Justo Arevalo, S.; Zapata Sifuentes, D.; Huallpa, C. J.; Landa Bianchi, G.; Castillo Chavez, A.; Garavito-Salini Casas, R.; Uribe Calampa, C. S.; Uceda-Campos, G.; Pineda Chavarria, R.
10.1101/2021.06.01.446571 — genomics — Posted on 2021-08-18
1744 Event segmentation reveals working memory forgetting rate
Jafarpour, A.; Buffalo, E.; Knight, R.; Collins, A.
10.1101/571380 — neuroscience — Posted on 2021-08-18
1747 Structure of Infective Getah Virus at 2.8 A-resolution Determined by Cryo-EM
Wang, A.; Zhou, F.; Liu, C.; Gao, D.; Qi, R.; Yin, Y.; Liu, S.; Gao, Y.; Fu, L.; Xia, Y.; Xu, Y.; Wang, C.; Liu, Z.
10.1101/2021.07.16.452580 — biophysics — Posted on 2021-08-18
1751 Under-Oil Autonomously Regulated Oxygen Microenvironments: A Goldilocks Principle-Based Approach For Microscale Cell Culture
Li, C.; Humayun, M.; Walker, G. M.; Park, K. Y.; Connors, B.; Feng, J.; Pellitteri Hahn, M. C.; Scarlett, C. O.; Li, J.; Feng, Y.; Clark, R. L.; Hefti, H.; Schrope, J.; Venturelli, O. S.; Beebe, D. J.
10.1101/2020.12.16.423117 — bioengineering — Posted on 2021-08-18
1759 Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models
Fu, F.; Pietropaolo, M.; Cui, L.; Pandit, S.; Li, W.; Tarnavski, O.; Shetty, S. S.; Liu, J.; Lussier, J. M.; Murakami, Y.; Grewal, P. K.; Deyneko, G.; Turner, G. M.; Taggart, A. K. P.; Waters, M. G.; Coughlin, S.; Adachi, Y.
10.1101/2021.08.17.456655 — physiology — Posted on 2021-08-17
1761 Metagenomic Discovery of CRISPR-Associated Transposons
Rybarski, J. R.; Hu, K.; Hill, A. M.; Wilke, C. O.; Finkelstein, I. J.
10.1101/2021.08.16.456562 — bioinformatics — Posted on 2021-08-17
1763 Genome sequencing of 196 Treponema pallidum strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar
Lieberman, N. A.; Lin, M. J.; Xie, H.; Shretha, L.; Nguyen, T.; Huang, M.-L.; Haynes, A. M.; Romeis, E.; Wang, Q.-Q.; Zhang, R.-L.; Kou, C.-X.; Ciccarese, G.; Dal Conte, I.; Cusini, M.; Drago, F.; Nakayama, S.-i.; Lee, K.; Ohnishi, M.; Konda, K. A.; Vargas, S. K.; Eguiluz, M.; Caceres, C.; Klausner, J. D.; Mitja, O.; Rompalo, A.; Mulcahy, F.; Hook, E. W.; Lukehart, S.; Casto, A. M.; Roychoudhury, P.; DiMaio, F.; Giacani, L.; Greninger, A. L.
10.1101/2021.08.17.456619 — genomics — Posted on 2021-08-17
1767 Transcriptomic analysis of astaxanthin hyper-producing Coelastrum sp. mutant obtained by chemical mutagenesis
Tharek, A.; Mohamad, S. E.; Suzuki, I.; Iwamoto, K.; Hara, H.; Yoshizaki, S.; Jamaluddin, H.; Salleh, M. M.; Yahya, A.
10.1101/2021.08.17.456660 — molecular biology — Posted on 2021-08-17
1773 Istaroxime metabolite PST3093 selectively stimulates SERCA2a and reverses disease-induced changes in cardiac function
Arici, M.; Ferrandi, M.; Hsu, S.-C.; Torre, E.; Barassi, P.; Luraghi, A.; Ronchi, C.; Chang, G.-J.; Peri, F.; Ferrari, P.; Bianchi, G.; Rocchetti, M.; Zaza, A.
10.1101/2021.08.17.455204 — pharmacology and toxicology — Posted on 2021-08-17
1779 wnt16 exerts pleiotropic effects on bone and lean mass in zebrafish
Watson, C. J.; Morfin Montes de Oca, E.; Fiedler, I. A. K.; Cronrath, A. R.; Callies, L. K.; Swearer, A. A.; Sethuraman, V.; Ahmed, A. R.; Monstad-Rios, A. T.; Rojas, M. F.; Tang, W. J.; Gardiner, E. M.; Busse, B.; Hsu, Y.-H.; Kwon, R. Y.
10.1101/2021.08.12.456120 — genetics — Posted on 2021-08-17
1781 Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety
Sato, D. X.; Inoue, Y. U.; Morimoto, Y.; Inoue, T.; Kuga, N.; Sasaki, T.; Ikegaya, Y.; Nomoto, K.; Kikusui, T.; Hattori, S.; Sala, G.; Hagihara, H.; Miyakawa, T.; Kawata, M.
10.1101/2021.05.18.444749 — evolutionary biology — Posted on 2021-08-17
1783 Characterisation of the Ubiquitin-ESCRT pathway in Asgard archaea sheds new light on origins of membrane trafficking in eukaryotes
Hatano, T.; Palani, S.; Papatziamou, D.; Salzer, R.; Souza, D.; Tamarit, D.; Makwana, M.; Potter, A.; Haig, A.; Xu, W.; Bellini, D.; Townsend, D.; Rochester, D.; Hussain, H.; Ettema, T.; Lowe, J.; Baum, B.; Robinson, N.; Balasubramanian, M.
10.1101/2021.08.17.456605 — cell biology — Posted on 2021-08-17
1784 Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation through N-formyl peptide receptor 2 in a chronic murine model of Chagas disease
Carrillo, I.; Rabelo, R.; Barbosa, C.; Rates, M.; Fuentes-Retamal, S.; Gonzalez-Herrera, F.; Guzman-Rivera, D.; Quintero, H.; Kemmerling, U.; Castillo, C.; Machado, F. S.; Maya, J. D.
10.1101/2021.08.17.456695 — microbiology — Posted on 2021-08-17
1785 Targeting interferon-{lambda} signaling promotes recovery from central nervous system autoimmunity
Manivasagam, S.; Williams, J. L.; Vollmer, L. L.; Bollman, B.; Bartleson, J. M.; Ai, S.; Wu, G. F.; Klein, R. S.
10.1101/2021.08.17.456642 — immunology — Posted on 2021-08-17
1786 Longitudinal monitoring of individual infection progression in Drosophila melanogaster
Ramirez-Corona, B. A.; Love, A. C.; Chandrasekaran, S.; Prescher, J. A.; Wunderlich, Z.
10.1101/2021.08.17.456698 — immunology — Posted on 2021-08-17
1788 Extracellular cues accelerate neurogenesis of induced pluripotent stem cell derived neurons
Sharlow, E.; Llaneza, D.; Mendelson, A.; Mingledorff, G.; Porterfield, V.; Salvati, K.; Beenhakker, M.; Bloom, G. S.; Lazo, J. S.
10.1101/2021.08.17.456634 — neuroscience — Posted on 2021-08-17
1790 A novel female-specific circadian clock mechanism regulating metabolism
Mekbib, T.; Suen, T.-C.; Rollins-Hairston, A.; Smith, K.; Armstrong, A.; Gray, C.; Baba, K.; Baggs, J.; Ehlen, J. C.; Tosini, G.; DeBruyne, J.
10.1101/2020.10.05.326652 — physiology — Posted on 2021-08-17
1792 Genetic editing of CISH enhances T cell effector programs independently of immune checkpoint cell surface ligand expression
Arthofer, E.; Chakraborty, K.; Viney, L.; Johnson, M. J.; Webber, B. R.; Moriarity, B. S.; Lou, E.; Choudhry, M.; Klebanoff, C. A.; Henley, T.
10.1101/2021.08.17.456714 — cancer biology — Posted on 2021-08-17
1794 Population-specific genome graphs improve high-throughput sequencing data analysis: A case study on the Pan-African genome
Tetikol, H. S.; Narci, K.; Turgut, D.; Budak, G.; Kalay, O.; Arslan, E.; Demirkaya-Budak, S.; Dolgoborodov, A.; Jain, A.; Kabakci-Zorlu, D.; Brown, R.; Semenyuk, V.; Davis-Dusenbery, B.
10.1101/2021.03.19.436173 — bioinformatics — Posted on 2021-08-17
1795 Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions
Song, A.; Hazlett, Z.; Abeykoon, D.; Dortch, J.; Dillon, A.; Curtiss, J.; Martinez, S. B.; Hill, C. P.; Yu, C.; Huang, L.; Fushman, D.; Cohen, R. E.; Yao, T.
10.1101/2021.08.17.456719 — biochemistry — Posted on 2021-08-17
1797 A nuclear role for the Argonaute protein AGO2 in mammalian gametogenesis
Griffin, K. N.; Li, H.; Walters, B. W.; Wang, H.; Kaya, C. B.; Kanyo, J.; Lam, T.; Cox, A. L.; Chung, J.-J.; Lesch, B. J.
10.1101/2021.08.17.456253 — developmental biology — Posted on 2021-08-17
1798 Expression Atlas of Avian Neural Crest Proteins: Neurulation to Migration
Monroy, B. Y.; Adamson, C. J.; Camacho-Avila, A.; Guerzon, C. N.; Echeverria, C. V.; Rogers, C. D.
10.1101/2021.08.17.456488 — developmental biology — Posted on 2021-08-17
1799 Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division
Opalko, H. E.; Miller, K. E.; Kim, H.-S.; Vargas-Garcia, C. A.; Singh, A.; Keogh, M.-C.; Moseley, J. B.
10.1101/2021.08.17.456680 — cell biology — Posted on 2021-08-17
1800 Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage function
Tuffs, S. W.; Goncheva, M. I.; Xu, S. X.; Craig, H. C.; Kasper, K. J.; Choi, J.; Flannagan, R. S.; Kerfoot, S. M.; Heinrichs, D. E.; McCormick, J. K.
10.1101/2021.08.17.456537 — microbiology — Posted on 2021-08-17
1801 Nicotinate degradation in a microbial eukaryote: a novel, complete pathway extant in Aspergillus nidulans
Bokor, E.; Amon, J.; Varga, M.; Szekeres, A.; Hegedus, Z.; Jakusch, T.; Flipphi, M.; Vagvolgyi, C.; Gacser, A.; Scazzocchio, C.; Hamari, Z.
10.1101/2021.08.17.456622 — microbiology — Posted on 2021-08-17
1802 Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected Patients
Cantoni, D.; Mayora-Neto, M.; Thakur, N.; Elrefaey, A. M.; Newman, J.; Vishwanath, S.; Nadesalingam, A.; Chan, A.; Smith, P.; Castillo-Olivares, J.; Baxendale, H.; Charleston, B.; Heeney, J.; Bailey, D.; Temperton, N.
10.1101/2021.08.17.456606 — microbiology — Posted on 2021-08-17
1804 Single cell based high-throughput Ig and TCR repertoire sequencing analysis in rhesus macaques
Walsh, E. S.; Tollison, T.; Brochu, H.; Shaw, B.; Diveley, K.; Chou, H.; Law, L.; Kirk, A.; Gale, M.; Peng, X.
10.1101/2021.08.17.456682 — immunology — Posted on 2021-08-17
1806 Individual variability of neural computations in the primate retina
Shah, N. P.; Brackbill, N.; Samarakoon, R. A.; Rhoades, C. E.; Kling, A.; Sher, A.; Litke, A.; Singer, Y.; Shlens, J.; Chichilnisky, E. J.
10.1101/2021.02.14.431169 — neuroscience — Posted on 2021-08-17
1807 Distinct neural circuits establish the same chemosensory behavior in C. elegans
Banerjee, N.; Shih, P.-Y.; Rojas Palato, E. J.; Sternberg, P. W.; Hallem, E.
10.1101/2021.08.17.456617 — neuroscience — Posted on 2021-08-17
1810 Mechanosensitivity of nucleocytoplasmic transport
Andreu, I.; Granero, I.; Chahare, N.; Clein, K.; Molina Jordan, M.; Beedle, A. E. M.; Elosegui-Artola, A.; Trepat, X.; Raveh, B.; Roca-Cusachs, P.
10.1101/2021.07.23.453478 — biophysics — Posted on 2021-08-17
1811 Height, but not binding epitope, affects the potency of synthetic TCR agonists
Wilhelm, K. B.; Morita, S.; McAffee, D. B.; Kim, S.; O'Dair, M. K.; Groves, J. T.
10.1101/2021.05.13.443919 — biophysics — Posted on 2021-08-17
1812 Refining Bulk Segregant Analyses: Ontology-Mediated Discovery of Flowering Time Genes in Brassica oleracea
Vos, R. A.; van der Veen-van Wijk, C. A. M.; Schranz, M. E.; Vrieling, K.; Klinkhamer, P. G. L.; Lens, F.
10.1101/2021.08.11.455982 — bioinformatics — Posted on 2021-08-17
1813 Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant
Zhang, J.; Xiao, T.; Cai, Y.; Lavine, C. L.; Peng, H.; Zhu, H.; Anand, K.; Tong, P.; Gautam, A.; Mayer, M. L.; Walsh, R. M.; Rits-Volloch, S.; Wesemann, D. R.; Yang, W.; Seaman, M. S.; Lu, J.; Chen, B.
10.1101/2021.08.17.456689 — biochemistry — Posted on 2021-08-17
1814 Making sense of the linear genome, gene function and TADs
Long, H. S.; Greenaway, S.; Powell, G.; Mallon, A.-M.; Lindgren, C. M.; Simon, M. M.
10.1101/2020.09.28.316786 — genomics — Posted on 2021-08-17
1815 Fitness effects of CTX-M-15-encoding IncF plasmids on their native Escherichia coli ST131 H30Rx hosts
Palkovicova, J.; Kutilova, I.; DelaFuente, J.; Medvecky, M.; Jamborova, I.; Bitar, I.; Phan, M.-D.; San Millan, A.; Dolejska, M.
10.1101/2021.08.17.456450 — evolutionary biology — Posted on 2021-08-17
1816 Functional Connectivity of the World's Protected Areas
Brennan, A.; Naidoo, R.; Greenstreet, L.; Mehrabi, Z.; Ramankutty, N.; Kremen, C.
10.1101/2021.08.16.456503 — ecology — Posted on 2021-08-17
1819 Critical Assessment of Metaproteome Investigation (CAMPI): a Multi-Lab Comparison of Established Workflows
Van Den Bossche, T.; Kunath, B. J.; Schallert, K.; Schäpe, S. S.; Abraham, P. E.; Armengaud, J.; Arntzen, M. O.; Bassignani, A.; Benndorf, D.; Fuchs, S.; Giannone, R. J.; Griffin, T. J.; Hagen, L. H.; Halder, R.; Henry, C.; Hettich, R. L.; Heyer, R.; Jagtap, P.; Jehmlich, N.; Jensen, M.; Juste, C.; Kleiner, M.; Langella, O.; Lehmann, T.; Leith, E.; May, P.; Mesuere, B.; Miotello, G.; Peters, S. L.; Pible, O.; Queiros, P. T.; Reichl, U.; Renard, B. Y.; Schiebenhoefer, H.; Sczyrba, A.; Tanca, A.; Trappe, K.; Trezzi, J.-P.; Uzzau, S.; Verschaffelt, P.; von Bergen, M.; Wilmes, P.; Wolf, M.; Marte
10.1101/2021.03.05.433915 — microbiology — Posted on 2021-08-17
1822 Playing with FiRE: A genome resolved view of the soil microbiome responses to high severity forest wildfire
Nelson, A. R.; Narrowe, A. B.; Rhoades, C. C.; Fegel, T. S.; Daly, R. A.; Roth, H. K.; Chu, R. K.; Amundson, K. K.; Geonczy, S. E.; Emerson, J. B.; Young, R. B.; Steindorff, A. S.; Mondo, S. J.; Grigoriev, I. V.; Salamov, A.; Borch, T.; Wilkins, M. J.
10.1101/2021.08.17.456416 — microbiology — Posted on 2021-08-17
1823 T Cell Predominant Response to AAV-Spike Protects hACE2 Mice from SARS-CoV-2 Pneumonia
Greer, C. D.; Kasden, C. M.; Morales, L.; Lundgreen, K. A.; Hicks, P. D.; Carpenter, L. J.; Salas-Quinchucua, C.; Tichy, E. D.; Maguire, A. M.; Hoffman, J. G.; Bailey, R. J.; Zhou, S.; Luo, A.; Chomistek, S. J.; Kozyak, B. W.; Bridges, C. R.; Gordon, G. S.; Tabin, G. C.; Bates, P. F.; Osorio, J. E.; Bennett, J.; Stedman, H. H.
10.1101/2021.08.16.456441 — immunology — Posted on 2021-08-17
1825 Drawing the Borders of Olfactory Space
Mayhew, E. J.; Arayata, C. J.; Gerkin, R. C.; Lee, B. K.; Magill, J. M.; Snyder, L. L.; Little, K. A.; Yu, C. W.; Mainland, J. D.
10.1101/2020.12.04.412254 — neuroscience — Posted on 2021-08-17
1830 Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
Fanfone, D.; Wu, Z. C.; Mammi, J.; Berthenet, K.; Neves, D.; Weber, K.; Halaburkova, A.; Virard, F.; Bunel, F.; Hernandez-Vargas, H.; Tait, S. W.; Hennino, A.; Ichim, G.
10.1101/2021.08.17.456592 — cancer biology — Posted on 2021-08-17
1831 A novel transposable element based authentication protocol for Drosophila cell lines
Mariyappa, D.; Rusch, D. B.; Han, S.; Luhur, A.; Overton, D.; Miller, D. F. B.; Bergman, C. M.; Zelhof, A. C.
10.1101/2021.08.16.456580 — genetics — Posted on 2021-08-17
1832 Treatment of a metabolic liver disease by in vivo prime editing in mice
Boeck, D.; Rothgangl, T.; Villiger, L.; Schmidheini, L.; Mathis, N.; Ioannidi, E.; Kontarakis, Z.; Kreutzer, S.; Rimann, N.; Grisch-Chan, H. M.; Thoeny, B.; Schwank, G.
10.1101/2021.08.17.456632 — genetics — Posted on 2021-08-17
1833 Comprehensive species sampling and sophisticated algorithmic approaches refute the monophyly of Arachnida
Ballesteros, J. A.; Santibanez-Lopez, C. E.; Baker, C. M.; Benavides, L. R.; Cunha, T. J.; Gainett, G.; Ontano, A. Z.; Setton, E. V.; Arango, C. P.; Gavish-Regev, E.; Harvey, M. S.; Wheeler, W. C.; Hormiga, G.; Giribet, G.; Sharma, P. P.
10.1101/2021.08.16.456573 — evolutionary biology — Posted on 2021-08-17
1836 Impact of Erg11 amino acid substitutions identified in Candida auris clade III isolates on triazole drug susceptibility
Williamson, B.; Wilk, A.; Guerrero, K. D.; Mikulski, T. D.; Elias, T. N.; Sawh, I.; Cancino-Prado, G.; Gardam, D.; Heath, C. H.; Govender, N. P.; Perlin, D. S.; Kordalewska, M.; Healey, K. R.
10.1101/2021.08.16.456589 — microbiology — Posted on 2021-08-17
1841 Spatiotemporally Resolved Multivariate Pattern Analysis for M/EEG
Higgins, C. J.; Vidaurre, D.; Kolling, N.; Liu, Y.; Behrens, T.; Woolrich, M.
10.1101/2021.08.17.456594 — neuroscience — Posted on 2021-08-17
1847 Reciprocal regulation of p21 and Chk1 controls the Cyclin D1-RB pathway to mediate senescence onset after DNA damage-induced G2 arrest
Lossaint, G.; Horvat, A.; Gire, V.; Bacevic, K.; Mrouj, K.; Charrier-Savournin, F.; Georget, V.; Fisher, D.; Dulic, V.
10.1101/2021.08.17.452482 — cell biology — Posted on 2021-08-17
1850 Core Protein-Directed Antivirals and Importinβ Can Synergistically Disrupt HBV Capsids
Kim, C.; Barnes, L. F.; Schlicksup, C. J.; Patterson, A. J.; Bothner, B.; Jarrold, M. F.; Wang, C.-Y. J.; Zlotnick, A.
10.1101/2021.08.16.456586 — microbiology — Posted on 2021-08-17
1851 Usutu virus uses langerin as a receptor to productively infect Langerhans cells more efficiently than West Nile virus.
Martin, M.-F.; Maarifi, G.; Abiven, H.; Seffals, M.; Mouchet, N.; Beck, C.; Bodet, C.; Leveque, N.; Arhel, N. J.; Blanchet, F. P.; Simonin, Y.; Nisole, S.
10.1101/2021.08.17.456611 — microbiology — Posted on 2021-08-17
1853 The clinical utility of two high-throughput 16S rRNA gene sequencing workflows for taxonomic assignment of unidentifiable bacterial pathogens in MALDI-TOF MS
Lao, H.-Y.; Ng, T. T. L.; Wong, R. Y. L.; Wong, C. S. T.; Chan, C. T. M.; Wong, D. S. H.; Lee, L. K.; Jim, S. H. C.; Leung, J. S. L.; Lo, H. W. H.; Wong, I. T. F.; YAU, M. C. Y.; Lam, J. Y.; Wu, A. K. L.; Siu, G. K. H.
10.1101/2021.08.16.456588 — microbiology — Posted on 2021-08-17
1854 Skin stem cells orchestrate de novo generation of extrathymic regulatory T cells to establish a temporary protective niche during wound healing
Truong, C.; Guo, W.; Woodside, L.; Gang, A.; Savage, P.; Infarinato, N.; Stewart, K.; Polak, L.; Levorse, J.; Pasolli, A.; Dikiy, S.; Rudensky, A.; Fuchs, E.; Miao, Y.
10.1101/2021.08.16.456570 — immunology — Posted on 2021-08-17
1856 Circulating microRNAs as noninvasive biomarkers for canine Cushing's syndrome
Sanders, K.; Veldhuizen, A.; Kooistra, H. S.; Slob, A.; Timmermans-Sprang, E. P. M.; Riemers, F. M.; Daminet, S.; Fracassi, F.; van Nimwegen, S. A.; Meij, B. P.; Galac, S.
10.1101/2021.08.17.456598 — cancer biology — Posted on 2021-08-17
1859 Deciphering Rubber Tree Growth Using Network-Based Multi Omics Approaches
Francisco, F. R.; Aono, A. H.; da Silva, C. C.; Gonçalves, P. d. S.; Scaloppi Júnior, E. J.; Guen, V. L.; Fritsche Neto, R.; Souza, L. M.; de Souza, A. P.
10.1101/2021.08.16.456528 — plant biology — Posted on 2021-08-17
1861 Stimulation of the Dorsal Root Ganglion using an Injectrode
Dalrymple, A. N.; Ting, J. E.; Bose, R.; Trevathan, J. K.; Nieuwoudt, S.; Lempka, S. F.; Franke, M.; Ludwig, K. A.; Shoffstall, A.; Fisher, L. E.; Weber, D. J.
10.1101/2021.08.16.456553 — bioengineering — Posted on 2021-08-17
1862 Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance
Muller, Y. D.; Ferreira, L. M. R.; Ronin, E.; Ho, P.; Nguyen, V.; Faleo, G.; Zhou, Y.; Lee, K.; Leung, K. K.; Skartsis, N.; Kaul, A. M.; Mulder, A.; Claas, F. H. J.; Wells, J. A.; Bluestone, J. A.; Tang, Q.
10.1101/2021.08.16.456548 — immunology — Posted on 2021-08-17
1864 Cervical Spinal Cord Injury Leads to Injury and Metabolic Dysfunction of the Lung
Huffman, E. E.; Dong, B. E.; Clarke, H. A.; Young, L. E.; Allison, D. B.; sun, r. c.; Waters, C. M.; Alilain, W. J.
10.1101/2021.08.16.455269 — neuroscience — Posted on 2021-08-17
1865 Columnar localization and laminar origin of cortical surface electrical potentials
Baratham, V. L.; Dougherty, M. E.; Ledochowitsch, P.; Maharbiz, M. M.; Bouchard, K.
10.1101/2021.08.16.456540 — neuroscience — Posted on 2021-08-17
1867 Molecular Swiss Army Knives: Tardigrade CAHS Proteins Mediate Desiccation Tolerance Through Multiple Mechanisms
Hesgrove, C. S.; Nguyen, K. H.; Biswas, S.; Childs, C. A.; KC, S.; Medina, B. X.; Alvarado, V.; Sukenik, S.; Yu, F.; Malferrari, M.; Francia, F.; Venturoli, G.; Martin, E. W.; Holehouse, A. S.; Boothby, T. C.
10.1101/2021.08.16.456555 — biophysics — Posted on 2021-08-17
1872 Functional Connectivity of the World's Protected Areas
Brennan, A.; Naidoo, R.; Greenstreet, L.; Mehrabi, Z.; Ramankutty, N.; Kremen, C.
10.1101/2021.08.16.456503 — ecology — Posted on 2021-08-17
1873 Molecular signature and target-specificity of inhibitory circuits formed by Martinotti cells in the mouse barrel cortex
Donato, C.; Cabezas, C.; Aguirre, A.; Lourenco, J.; Potier, M.-C.; Zorrilla de San Martin, J.; Bacci, A.
10.1101/2021.08.16.455953 — neuroscience — Posted on 2021-08-17
1877 A point mutation in the kinase domain of CRK10 leads to xylem vessel collapse and activates defence responses
Piovesana, M.; Machado Wood, A. K.; Smith, D. P.; Deery, M.; Bayliss, R.; Carrera, E.; Napier, J.; Kurup, S.; Matthes, M. C.
10.1101/2021.08.16.456532 — plant biology — Posted on 2021-08-17
1878 The dynamic interaction of systemic inflammation and the hypothalamic-pituitary-adrenal (HPA) axis during and after major surgery
Galvis, D.; Zavala, E.; Walker, J. J.; Upton, T.; Lightman, S. L.; Angelini, G. D.; Evans, J.; Rogers, C. A.; Phillips, K.; Gibbison, B.
10.1101/2021.08.16.456512 — physiology — Posted on 2021-08-17
1879 Leptin Signalling in the Ovary of Diet-Induced Obese Mice Regulates Activation of Nod-Like Receptor Protein 3 Inflammasome
Adamowski, M.; Wolodko, K.; Oliveira, J.; Castillo-Fernandez, J.; Murta, D.; Kelsey, G. D.; Galvao, A.
10.1101/2021.08.16.456479 — physiology — Posted on 2021-08-17
1880 A user-friendly tool for cloud-based whole slide image segmentation, with examples from renal histopathology
Lutnick, B. R.; Manthey, D.; Becker, J. U.; Ginley, B.; Moos, K.; Zuckerman, J. E.; Rodrigues, L.; Gallan, A. J.; Barisoni, L.; Alpers, C. E.; Wang, X.; Myakala, K.; Jones, B. A.; Levi, M.; Kopp, J. B.; Yoshida, T.; Han, S. S.; Jain, S.; Rosenberg, A. Z.; Jen, K. Y.; Sarder, P.; Kidney Precision Medicine Project,
10.1101/2021.08.16.456524 — pathology — Posted on 2021-08-17
1881 Let-7b-5p, miR-184, and miR-22-3p: Multianalyte Plasma Biomarkers for NSCLC Diagnosis and for Predicting Resistance to Osimertinib
Vadla, G. P.; Dhagat, B.; Garcia, A.; Perez, G.; Ahmad, V.; Patterson, N.; Manjunath, Y.; Kaifi, J.; Li, G.; Chabu, C. Y.
10.1101/2021.08.15.456411 — cancer biology — Posted on 2021-08-17
1885 2020 BioImage Analysis Survey: Community experiences and needs for the future
Jamali, N.; Dobson, E. T.; Eliceiri, K. W.; Carpenter, A. E.; Cimini, B. A.
10.1101/2021.08.16.456498 — bioinformatics — Posted on 2021-08-17
1887 Spatial analysis for highly multiplexed imaging data to identify tissue microenvironments
Patrick, E.; Canete, N. P.; Iyengar, S. S.; Harman, A. N.; Sutherland, G. T.; Yang, P.
10.1101/2021.08.16.456469 — bioinformatics — Posted on 2021-08-17
1888 SeqDistK: a Novel Tool for Alignment-free Phylogenetic Analysis
Liu, X.; Li, W.; Huang, G.; Huang, T.; Xiong, Q.; Chen, W.; Xia, L. C.
10.1101/2021.08.16.456500 — bioinformatics — Posted on 2021-08-17
1894 On the nature of the earliest known life forms
Kanaparthi, D.; Lampe, M.; Zhu, B.; Boesen, T.; Klingl, A.; Schwille, P.; Lueders, T.
10.1101/2021.08.16.456462 — evolutionary biology — Posted on 2021-08-17
1895 Association between Neighborhood Socioeconomic Status and Executive System Activation in Youth
Murtha, K. A.; Larsen, B.; Pines, A. R.; Parkes, L. M.; Moore, T. M.; Adebimpe, A.; Alexander-Bloch, A.; Calkins, M. E.; Davila, D. G.; Lindquist, M. A.; Mackey, A. P.; Roalf, D. R.; Scott, J. C.; Wolf, D. H.; Gur, R. C.; Gur, R. E.; Barzilay, R. A.; Satterthwaite, T. D.
10.1101/2021.08.12.454903 — neuroscience — Posted on 2021-08-17
1898 Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins
Malm, M.; Kuo, C.-C.; Moradi Barzadd, M.; Mebrahtu, A.; Wistabacka, N.; Razavi, R.; Volk, A.-L.; Lunqvist, M.; Kotol, D.; Edfors, F.; Graslund, T.; Chotteau, V.; Field, R.; Varley, P. G.; Roth, R. G.; Lewis, N.; Hatton, D.; Rockberg, J.
10.1101/2021.08.16.455786 — systems biology — Posted on 2021-08-17
1899 Inferring mammalian tissue-specific regulatory conservation by predicting tissue-specific differences in open chromatin
Kaplow, I. M.; Schaffer, D. E.; Wirthlin, M. E.; Lawler, A. J.; Brown, A. R.; Kleyman, M.; Pfenning, A. R.
10.1101/2020.12.04.410795 — genetics — Posted on 2021-08-17
1903 Telencephalic outputs from the medial entorhinal cortex are copied directly to the hippocampus
Tsoi, S. Y.; Öncül, M.; Svahn, E.; Robertson, M.; Bogdanowicz, Z.; McClure, C.; Sürmeli, G.
10.1101/2021.03.10.434566 — neuroscience — Posted on 2021-08-17
1906 Bone mineral density modeling via random field: normality, stationarity, sex and age dependence
Henys, P.; Vorechovsky, M.; Kuchar, M.; Heinemann, A.; Kopal, J.; Ondruschka, B.; Hammer, N.
10.1101/2021.02.25.432881 — biophysics — Posted on 2021-08-17
1907 Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer's disease
KANESHIRO, N.; MASATO, K.; IMAOKA, R.; IKEDA, A.; KAMIKUBO, Y.; HASHIMOTO, T.; IWATSUBO, T.; SAKURAI, T.; UEHARA, T.; TAKASUGI, N.
10.1101/2021.07.30.454423 — biochemistry — Posted on 2021-08-17
1908 Structural basis for feedforward control in the PINK1/parkin pathway
Sauve, V.; Sung, G.; MacDougall, E.; Kozlov, G.; Saran, A.; Fakih, R.; Fon, E. A.; Gehring, K.
10.1101/2021.08.16.456440 — biochemistry — Posted on 2021-08-17
1909 Seizures, behavioral deficits and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy
Santoro, B.; Merseburg, A.; Kasemir, J.; Buss, E. W.; Leroy, F.; Bock, T.; Porro, A.; Barnett, A.; Tröder, S. E.; Engeland, B.; Stockebrand, M.; Moroni, A.; Siegelbaum, S.; Isbrandt, D.
10.1101/2021.08.16.456452 — neuroscience — Posted on 2021-08-17
1910 PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix
Kay, E. J.; Paterson, K.; Riero Domingo, C.; Sumpton, D.; Daebritz, H.; Tardito, S.; Boldrini, C.; Hernandez-Fernaud, J. R.; Athineos, D.; Dhayade, S.; Stepanova, E.; Gjerga, E.; Neilson, L. J.; Lilla, S.; Hedley, A.; Koulouras, G.; McGregor, G.; Jamieson, C.; Johnson, R. M.; Park, M.; Kirschner, K.; Miller, C.; Kamphorst, J.; Loayza-Puch, F.; Saez-Rodriguez, J.; Mazzone, M.; Blyth, K.; Zagnoni, M.; Zanivan, S.
10.1101/2020.05.30.125237 — cancer biology — Posted on 2021-08-17
1913 Landscape management for grassland multifunctionality
Neyret, M.; Fischer, M.; Allan, E.; Hoelzel, N.; Klaus, V.; Kleinebecker, T.; Krauss, J.; Le Provost, G.; Peter, S.; Schenk, N.; Simons, N. K.; van der Plas, F.; Binkenstein, J.; Boerschig, C.; Jung, K.; Prati, D.; Schaefer, D.; Schaefer, M.; Schoening, I.; Schrumpf, M.; Tschapka, M.; Westphal, C.; Manning, P.
10.1101/2020.07.17.208199 — ecology — Posted on 2021-08-17
1915 Global genome decompaction leads to stochastic activation of gene expression as a first step toward fate commitment in human hematopoietic stem cells.
Parmentier, R.; Moussy, A.; Chantalat, S.; Racine, L.; Ravi, S.; Gao, N. P.; Stockholm, D.; Corre, G.; Fourel, G.; Deleuze, J.-F.; Gunawan, R.; Paldi, A.
10.1101/2020.09.09.289751 — cell biology — Posted on 2021-08-17
1917 Deciphering Multi-way Interactions in the Human Genome
Lindsly, S. M.; Chen, C.; Dilworth, S.; Jeyarajan, S.; Stansbury, C.; Cicalo, A.; Meixner, W.; Beckloff, N.; Ryan, C.; Surana, A.; Wicha, M.; Omenn, G.; Muir, L.; Rajapakse, I.
10.1101/2021.08.15.456363 — bioinformatics — Posted on 2021-08-17
1919 Genetic analysis of early phenology in lentil identifies distinct loci controlling component traits
Rajandran, V.; Ortega Martinez, R.; Vander Schoor, J. K.; Butler, J. B.; Freeman, J. S.; Hecht, V. F.; Erskine, W.; Murfet, I. C.; Bett, K. E.; Weller, J. L.
10.1101/2021.08.16.456438 — genetics — Posted on 2021-08-17
1923 Optimized guide RNA selection recommendations for using spCas9 gene editing in human hematopoietic stem and progenitor cells
Verhagen, H. J.; Kuijk, C.; Kokke, A. M.; Rutgers, L.; van der Meulen, S.; van Mierlo, G.; Voermans, C.; Van den akker, E.
10.1101/2020.12.18.423329 — molecular biology — Posted on 2021-08-17
1924 A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein
Rick, T.; Kreiling, V.; Hoing, A.; Fiedler, S.; Glatter, T.; Steinchen, W.; Hochberg, G.; Bahre, H.; Seifert, R.; Bange, G.; Knauer, S. K.; Graumann, P. L.; Thormann, K. M.
10.1101/2021.08.12.456111 — microbiology — Posted on 2021-08-17
1925 Single-cell lineage trajectories and chromatin regulators that initialize antiviral CD8 T cell ontogeny
Diao, H.; Chen, R.; Tsuda, S. M.; Wang, D.; Frederick, M. A.; Kim, J.; Karunadharma, P.; Martinez, G.; Getzler, A. J.; Toma, C.; Milner, J.; Venables, T. C.; Martin, D. M.; Goldrath, A. W.; Crotty, S.; Pipkin, M. E.
10.1101/2021.08.11.456014 — immunology — Posted on 2021-08-17
1926 Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
Sadeghi, I.; Gispert, J. D.; Palumbo, E.; Munoz-Aguirre, M.; Wucher, V.; D'Argenio, V.; Santpere, G.; Navarro, A.; Guigo, R.; Vilor-Tejedor, N.
10.1101/2021.08.16.456345 — neuroscience — Posted on 2021-08-16
1927 From contigs to chromosomes: automatic Improvement of Long Read Assemblies (ILRA)
Ruiz, J. L.; Reimering, S.; Sanders, M.; Escobar-Prieto, J. D.; Brancucci, N. M. B.; Echeverry, D. F.; Abdi, A. I.; Marti, M.; Gomez-Diaz, E.; Otto, T. D.
10.1101/2021.07.30.454413 — bioinformatics — Posted on 2021-08-17
1928 Particle Uptake Driven Phagocytosis in Macrophages and Neutrophils Enhances Bacterial Clearance
Sharma, P.; Vijaykumar, A.; Raghavan, J. V.; Rananaware, S. R.; Alakesh, A.; Bodele, J.; Rehman, J. U.; Shukla, S.; Nadig, S.; Wagde, V.; Chakrabarti, S.; Visweswariah, S. S.; Nandi, D.; Gopal, B.; Jhunjhunwala, S.
10.1101/2021.08.16.456482 — immunology — Posted on 2021-08-16
1929 Adolescent development of multiscale cortical wiring and functional connectivity in the human connectome
Park, B.-y.; Paquola, C.; Bethlehem, R. A. I.; Benkarim, O.; Neuroscience in Psychiatry Network (NSPN) Consortium, ; Misic, B.; Smallwood, J.; Bullmore, E. T.; Bernhardt, B.
10.1101/2021.08.16.456455 — neuroscience — Posted on 2021-08-16
1931 Clonal dynamics of haematopoiesis across the human lifespan
Mitchell, E.; Spencer Chapman, M.; Williams, N.; Dawson, K.; Mende, N.; Calderbank, E. F.; Jung, H.; Mitchell, T. J.; Coorens, T.; Spencer, D. H.; Machado, H.; Lee-Six, H.; Davies, M.; Hayler, D.; Fabre, M.; Mahbubani, K.; Abascal, F.; Cagan, A.; Vassiliou, G.; Baxter, J.; Martincorena, I.; Stratton, M.; Kent, D.; Chatterjee, K.; Saeb Parsy, K.; Green, A. R.; Nangalia, J.; Laurenti, E.; Campbell, P.
10.1101/2021.08.16.456475 — genomics — Posted on 2021-08-16
1934 Regulation of gliotoxin biosynthesis and protection in Aspergillus species
de Castro, P. A.; Moraes, M.; Colabardini, A. C.; Horta, M. A. C.; Knowles, S. L.; Raja, H. A.; Oberlies, N. H.; Koyama, Y.; Ogawa, M.; Gomi, K.; Steenwyk, J. L.; Rokas, A.; Ries, L. N. A.; Goldman, G. H.
10.1101/2021.08.16.456458 — microbiology — Posted on 2021-08-16
1938 HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities.
Kalmar, L.; Gupta, S.; Kean, I.; Ba, X.; Hadjirin, N.; Lay, E.; De Vries, S.; Bateman, M.; Bartlett, H.; Hernandez-Garcia, J.; Tucker, A.; Restiff, O.; Stevens, M.; Wood, J.; Maskell, D.; Grant, A.; Holmes, M.
10.1101/2021.08.16.456459 — bioinformatics — Posted on 2021-08-16
1940 Metagenomic Discovery of CRISPR-Associated Transposons
Rybarski, J. R.; Hu, K.; Hill, A. M.; Wilke, C. O.; Finkelstein, I. J.
10.1101/2021.08.16.456562 — bioinformatics — Posted on 2021-08-16
1941 Haploinsufficiency of the mouse Tshz3 gene leads to kidney dysfunction
Sanchez-Martin, I.; Magalhaes, P.; Fatmi, A.; Richard, F.; Vu Manh, T.-P.; Saurin, A. J.; Feuillet, G.; Denis, C.; Schanstra, J. P.; Zurbig, P.; Caubit, X.; Fasano, L.
10.1101/2021.08.16.456481 — genetics — Posted on 2021-08-16
1945 Ribosome collisions in bacteria promote ribosome rescue by triggering mRNA cleavage by SmrB
Saito, K.; Kratzat, H.; Campbell, A.; Buschauer, R.; Burroughs, A. M.; Berninghausen, O.; Aravind, L.; Beckmann, R.; Green, R.; Buskirk, A. R.
10.1101/2021.08.16.456513 — molecular biology — Posted on 2021-08-16
1947 OpenNeuro: An open resource for sharing of neuroimaging data
Markiewicz, C. J.; Gorgolewski, K. J.; Feingold, F.; Blair, R.; Halchenko, Y. O.; Miller, E.; Hardcastle, N.; Wexler, J.; Esteban, O.; Goncalves, M.; Jwa, A. S.; Poldrack, R.
10.1101/2021.06.28.450168 — neuroscience — Posted on 2021-08-16
1949 Inhibition of BCMA signaling alters protein translation and Multiple Myeloma growth
Miao, Y. R.; Cenik, C.; Jiang, D.; Mizuno, K.; Li, G. C.; Zhao, H.; Thakker, K.; Diep, A.; Xu, J. Y.; Zhang, X. E.; Liedtke, M.; Abidi, P.; Leung, W.-s.; Koong, A. C.; Giaccia, A. J.
10.1101/2021.05.03.442500 — cancer biology — Posted on 2021-08-16
1950 Frog nest foams exhibit pharmaceutical foam-like properties
Brozio, S.; O Shaughnessy, E. M.; Woods, S.; Hall-Barrientos, I.; Martin, P. E.; Kennedy, M. W.; Lamprou, D.; Hoskisson, P. A.
10.1101/2021.01.06.425559 — bioengineering — Posted on 2021-08-16
1951 MDH2 is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle
Molinie, T.; Cougouilles, E.; David, C.; Cahoreau, E.; Portais, J.-C.; Mourier, A.
10.1101/2021.04.17.440272 — biochemistry — Posted on 2021-08-16
1952 The Cdc14 phosphatase controls resolution of recombination intermediates and crossover formation during meiosis
Alonso-Ramos, P.; Alvarez-Melo, D.; Strouhalova, K.; Pascual-Silva, C.; Garside, G. B.; Arter, M.; Bermejo, T.; Grigaitis, R.; Wettstein, R.; Fernandez-Diaz, M.; Matos, J.; Geymonat, M.; San-Segundo, P. A.; Carballo, J. A.
10.1101/571083 — genetics — Posted on 2021-08-16
1953 Combining climatic and genomic data improves range-wide tree height growth prediction in a forest tree
Archambeau, J.; Benito Garzon, M.; Barraquand, F.; de Miguel Vega, M.; Plomion, C.; C. Gonzalez-Martinez, S.
10.1101/2020.11.13.382515 — genetics — Posted on 2021-08-16
1954 Patterns of and processes shaping population structure and introgression among recently differentiated Drosophila melanogaster populations
Coughlan, J. M.; Dagilis, A.; Serrato-Capuchina, A.; Elias, H.; Peede, D.; Isbell, K.; Castillo, D. M.; Cooper, B. S.; Matute, D. R.
10.1101/2021.06.25.449842 — evolutionary biology — Posted on 2021-08-16
1958 The Nab2 RNA binding protein promotes sex-specific splicing of Sex lethal in Drosophila neuronal tissue
Jalloh, B.; Rounds, J. C.; Brown, B.; Lancaster, C. L.; Leung, S.; Banerjee, A.; Morton, D. J.; Bienkowski, R.; Kremsky, I.; Fasken, M. B.; Corbett, A. H.; Moberg, K. H.
10.1101/2020.11.13.382168 — developmental biology — Posted on 2021-08-16
1960 Centriole distal-end proteins CP110 and Cep97 influence cartwheel growth at the proximal-end of centrioles
Aydogan, M. G.; Hankins, L. E.; Steinacker, T. L.; Mofatteh, M.; Saurya, S.; Wainman, A.; Wong, S. S.; Lu, X.; Zhou, F. Y.; Raff, J. W.
10.1101/2021.07.08.451650 — cell biology — Posted on 2021-08-16
1962 SufB intein splicing in Mycobacterium tuberculosis is influenced by two remote conserved N-extein Histidines
Panda, S.; Nanda, A.; Sahu, N.; Ojha, D. K.; Pradhan, B.; Rai, A.; Suryawanshi, A. R.; Banavali, N.; Nayak, S.
10.1101/2021.07.07.451452 — molecular biology — Posted on 2021-08-16
1963 Bacterial DNA on the skin surface overrepresents the viable skin microbiome
Acosta, E. M.; Little, K. A.; Bratton, B. P.; Mao, X.; Payne, A. S.; Devenport, D.; Gitai, Z.
10.1101/2021.08.16.455933 — microbiology — Posted on 2021-08-16
1965 Understanding the microbial biogeography of ancient human dentitions to guide study design and interpretation
Fagernäs, Z.; Salazar-Garcia, D. C.; Aviles, A.; Haber, M.; Henry, A.; Lomba Maurandi, J.; Ozga, A.; Velsko, I. M.; Warinner, C.
10.1101/2021.08.16.456492 — microbiology — Posted on 2021-08-16
1966 Nanobody Mediated Macromolecular Crowding Induces Membrane Fission and Remodeling in the African Trypanosome
Hempelmann, A.; Hartleb, L.; Van Straaten, M.; Hashemi, H.; Zeelen, J. P.; Papavasiliou, F. N.; Engstler, M.; Stebbins, C. E.; Jones, N. G.
10.1101/2021.01.13.426364 — microbiology — Posted on 2021-08-16
1967 Genomic features of Mycobacterium avium subsp. hominissuis isolated from pigs in Japan.
Komatsu, T.; Ohya, K.; Ota, A.; Nishiuchi, Y.; Yano, H.; Matsuo, K.; Odoi, J. O.; Suganuma, S.; Sawai, K.; Hasebe, A.; Asai, T.; Yanai, T.; Fukushi, H.; Wada, T.; Yoshida, S.; Ito, T.; Arikawa, K.; Kawai, M.; Ato, M.; Baughn, A. D.; Iwamoto, T.; MARUYAMA, F.
10.1101/2021.06.15.447579 — microbiology — Posted on 2021-08-16
1973 Temporal specificity of abnormal neural oscillations during phonatory events in Laryngeal Dystonia
Kothare, H.; Schneider, S.; Mizuiri, D.; Hinkley, L.; Bhutada, A.; Ranasinghe, K.; Honma, S.; Garrett, C.; Klein, D.; Naunheim, M.; Yung, K.; Cheung, S.; Rosen, C.; Courey, M.; Nagarajan, S.; Houde, J.
10.1101/2021.04.08.438908 — neuroscience — Posted on 2021-08-16
1974 Role of protein degradation in growth laws
Calabrese, L.; Grilli, J.; Osella, M.; Kempes, C. P.; Cosentino Lagomarsino, M.; Ciandrini, L.
10.1101/2021.03.25.436692 — systems biology — Posted on 2021-08-16
1984 Generation of chimeric respiratory viruses with altered tropism by coinfection of influenza A virus and respiratory syncytial virus
Haney, J.; Vijayakrishnan, S.; Streetley, J.; Dee, K.; Goldfarb, D.; Clarke, M.; Mullin, M.; Carter, S. D.; Bhella, D.; Murcia, P. R.
10.1101/2021.08.16.456460 — microbiology — Posted on 2021-08-16
1985 The Molecular Basis of FimT-mediated DNA Uptake during Bacterial Natural Transformation
Braus, S. A. G.; Short, F. L.; Holz, S.; Stedman, M. J. M.; Gossert, A. D.; Hospenthal, M. K.
10.1101/2021.08.16.456509 — microbiology — Posted on 2021-08-16
1986 Positive and negative control of helicase recruitment at a bacterial chromosome origin
Winterhalter, C.; Stevens, D.; Fenyk, S.; Pelliciari, S.; Marchand, E.; Cronin, N. B.; Soultanas, P.; Costa, T.; Ilangovan, A.; Murray, H.
10.1101/2021.08.16.456468 — microbiology — Posted on 2021-08-16
1987 Toxoplasma infection alters dopamine-sensitive behaviors and host gene expression patterns associated with neuropsychiatric disease
Cromar, G. L.; Epp, J. R.; Popovic, A.; Gu, Y.; Ha, V.; Walters, B.; St. Pierre, J.; Xiong, X.; Howland, J. G.; Josselyn, S.; Parkinson, J.; Frankland, P. W.
10.1101/2021.08.16.456298 — microbiology — Posted on 2021-08-16
1989 Molecular basis of a dominant SARS-CoV-2 Spike-derived epitope presented by HLA-A*02:01 recognised by a public TCR
Szeto, C.; Nguyen, A. T.; Lobos, C. A.; Chatzileontiadou, D. S.; Jayasinghe, D.; Grant, E. J.; Riboldi-Tunnicliffe, A.; Smith, C.; Gras, S.
10.1101/2021.08.15.456333 — immunology — Posted on 2021-08-16
1990 SMOG 2 and OpenSMOG: Extending the limits of structure-based models
Oliveira, A. B.; Contessoto, V.; Hassan, A.; Byju, S.; Wang, A.; Wang, Y.; Dodero Rojas, E. G.; Mohanty, U.; Noel, J.; Onuchic, J. N.; Whitford, P. C.
10.1101/2021.08.15.456423 — biophysics — Posted on 2021-08-16
1992 ImputeCoVNet: 2D ResNet Autoencoder for Imputation of SARS-CoV-2 Sequences
Pesaranghader, A.; Pelletier, J.; Grenier, J.-C.; Poujol, R.; Hussin, J.
10.1101/2021.08.13.456305 — bioinformatics — Posted on 2021-08-16
1993 Cutting epitopes to survive: the case of lambda variant
Pascarella, S.; Ciccozzi, M.; Bianchi, M.; Benvenuto, D.; Cauda, R.; Cassone, A.
10.1101/2021.08.14.456353 — bioinformatics — Posted on 2021-08-16
1998 Infection and transmission of SARS-CoV-2 and its alpha variant in pregnant white-tailed deer
Cool, K.; Gaudreault, N. N.; Morozov, I.; Trujillo, J. D.; Meekins, D. A.; McDowell, C.; Carossino, M.; Bold, D.; Kwon, T.; Balaraman, V.; Madden, D. W.; Libanori Artiaga, B.; Pogranichniy, R. M.; Roman Sosa, G.; Henningson, J.; Wilson, W. C.; Balasuriya, U. B. R.; Garcia-Sastre, A.; Richt, J. A.
10.1101/2021.08.15.456341 — microbiology — Posted on 2021-08-16
1999 A screening pipeline identifies a broad-spectrum inhibitor of bacterial AB toxins with cross protection against influenza A virus H1N1 and SARS-CoV-2
Wu, Y.; Mahtal, N.; Swistak, L.; Sagadiev, S.; Acharya, M.; Demeret, C.; Van der Werf, S.; Guivel-Benhassine, F.; Schwartz, O.; Petracchini, S.; Mettouchi, A.; Paillares, E.; Caramelle, L.; Couvineau, P.; Thai, R.; Barbe, P.; Keck, M.; Brodin, P.; Machelart, A.; Sencio, V.; Trottein, F.; Sachse, M.; Chicanne, G.; Payrastre, B.; Ville, F.; Kreis, V.; Popoff, M.-R.; Johannes, L.; Cintrat, J.-C.; Barbier, J.; Gillet, D.; Lemichez, E.
10.1101/2021.08.13.454991 — microbiology — Posted on 2021-08-16
2001 Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model
Jiang, S.; Wu, S.; Zhao, G.; He, Y.; Bao, L.; Liu, J.; Qin, C.; Hou, J.; Ding, Y.; Wu, J.; Yan, J.; Humeau, L.; Patella, A.; Weiner, D. B.; Broderick, K.; Wang, B.
10.1101/2021.08.13.456164 — immunology — Posted on 2021-08-16
2002 Optimization of Non-Coding Regions Improves Protective Efficacy of an mRNA SARS-CoV-2 Vaccine in Nonhuman Primates
Gebre, M.; Rauch, S.; Roth, N.; Yu, J.; Chandrashekar, A.; Mercado, N.; He, X.; Liu, J.; McMahan, K.; Martinot, A.; Giffin, T.; Hope, D.; Patel, S.; Sellers, D.; Sanborn, O.; Barrett, J.; Liu, X.; Cole, A.; Pessaint, L.; Valentin, D.; Flinchbaugh, Z.; Yalley-Ogunro, J.; Muench, J.; Brown, R.; Cook, A.; Teow, E.; Andersen, H.; Lewis, M. G.; Mueller, S.; Petsch, B.; Barouch, D. H.
10.1101/2021.08.13.456316 — immunology — Posted on 2021-08-16
2006 Real-Time Search Assisted Acquisition on a Tribrid Mass Spectrometer Improves Coverage in Multiplexed Single-Cell Proteomics
Furtwängler, B.; Üresin, N.; Motamedchaboki, K.; Huguet, R.; Lopez-Ferrer, D.; Zabrouskov, V.; Porse, B. T.; Schoof, E. M.
10.1101/2021.08.16.456445 — biochemistry — Posted on 2021-08-16
2007 The β-cell primary cilium is an autonomous Ca2+ compartment for paracrine GABA signalling
Sanchez, G.; Incedal, T. C.; Salcedo, J. P.; O'Callaghan, P.; Echeverry, S.; Nguyen, P. M.; Xie, B.; Barg, S.; Kreuger, J.; Dandekar, T.; Idevall-Hagren, O.
10.1101/2021.08.16.456473 — cell biology — Posted on 2021-08-16
2008 SMC protein RecN drives translocation and remodelling of RecA filament for homology search
Chimthanawala, A.; Parmar, J.; Kumar, S.; Iyer, K. S.; Rao, M.; Badrinarayanan, A.
10.1101/2021.08.16.456443 — cell biology — Posted on 2021-08-16
2012 Optimized analysis for sensitive detection and analysis of single proteins via interferometric scattering microscopy
Mirzaalian Dastjerdi, H.; Dahmardeh, M.; Gemeinhardt, A.; Gholami Mahmoodabadi, R.; Köstler, H.; Sandoghdar, V.
10.1101/2021.08.16.456463 — biophysics — Posted on 2021-08-16
2015 Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells
Dr. Novoselova, I. P.; Neusch, A.; Brand, J.-S.; Otten, M.; Safari, M. R.; Bartels, N.; Prof. Karg, M.; Prof. Farle, M.; PD Wiedwald, U.; Prof. Monzel, C.
10.1101/2021.08.16.455233 — bioengineering — Posted on 2021-08-16
2017 Genetic analysis of early phenology in lentil identifies distinct loci controlling component traits
Weller, J. L.; Hecht, V. F. G.; Ortega Martinez, R.; Rajandran, V.; Vander Schoor, J.; Butler, J.; Freeman, J.; Bett, K.; Murfet, I.; Erskine, W.
10.1101/2021.08.16.456438 — genetics — Posted on 2021-08-16
2019 Diversity and evolution of amphibian pupil shapes
Thomas, K. N.; Rich, C.; Quock, R.; Streicher, J. W.; Gower, D. J.; Schott, R. K.; Fujita, M. K.; Bell, R. C.
10.1101/2021.08.15.456426 — evolutionary biology — Posted on 2021-08-16
2022 Arg1+ microglia are critical for shaping cognition in female mice
Stratoulias, V.; Ruiz, R.; Kanatani, S.; Osman, A. M.; Armengol, J. A.; Rodriguez-Moreno, A.; Murgoci, A.-N.; Garcia-Dominguez, I.; Keane, L.; Vazquez-Carbera, G.; Alonso-Bellido, I.; Vernoux, N.; Tejera, D.; Grabert, K.; Cheray, M.; Gonzalez-Rodriguez, P.; Perez-Villegas, E. M.; Martinez-Gallego, I.; Brodin, D.; Avila-Carino, J.; Airavaara, M.; Uhlen, P.; Heneka, M. T.; Tremblay, M.-E.; Blomgren, K.; Venero, J. L.; Joseph, B.
10.1101/2021.08.15.456225 — neuroscience — Posted on 2021-08-16
2025 Non-invasive imaging of gene expression and protein secretion dynamics in living mice
Nourse, J.; Tokalov, S.; Khokhar, S.; Khan, E.; Schott, L. K.; Hinz, L.; Eder, L.; Arnold-Schild, D.; Probst, H. C.; Danckwardt, S.
10.1101/2021.07.08.451623 — cancer biology — Posted on 2021-08-16
2027 Defective Slc7a7 transport reduces systemic arginine availability compromising erythropoiesis and iron homeostasis
Sotillo, F.; Giroud-Gerbetant, J.; Couso, J.; Artuch, R.; Zorzano, A.; Ormazabal, A.; Sanchez, M.; Weiss, G.; Bodoy, S.; Palacin, M.
10.1101/2021.08.15.456393 — molecular biology — Posted on 2021-08-16
2030 Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas
Webster, A. L. H.; Sanders, M. A.; Patel, K.; Dietrich, R.; Noonan, R. J.; Lach, F. P.; White, R. R.; Goldfarb, A.; Hadi, K.; Edwards, M. M.; Donovan, F. X.; Jung, M.; Sridhar, S.; Fedrigo, O.; Tian, H.; Rosiene, J.; Heineman, T.; Kennedy, J. A.; Bean, L.; Rosti, O.; Tryon, R.; Gonzalez, A.-M.; Rosenberg, A.; Luo, J.-D.; Carrol, T.; Velleuer, E.; Rastatter, J. C.; Wells, S. I.; Surralles, J.; Bagby, G.; MacMillan, M. L.; Wagner, J. E.; Cancio, M.; Boulad, F.; Scognamiglio, T.; Vaughan, R.; Koren, A.; Imielinski, M.; Chandrasekharappa, S.; Auerbach, A. D.; Singh, B.; Kutler, D. I.; Campbell, P.
10.1101/2021.08.14.456365 — cancer biology — Posted on 2021-08-16
2035 P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis
Zhu, M.; Peng, R.; Liang, X.; Lan, Z.; Tang, M.; Hou, P.; Song, J. H.; Mak, C. S. L.; Park, J.; Zheng, S.-e.; Huang, A.; Ma, X.; Chen, R.; Chang, Q.; Logothetis, C. J.; Jain, A. K.; Lin, S.-H.; Katayama, H.; Hanash, S. M.; Wang, G.
10.1101/2021.01.24.428024 — cancer biology — Posted on 2021-08-16
2036 Model design for non-parametric phylodynamic inference and applications to pathogen surveillance
Didelot, X.; Geidelberg, L.; The COVID-19 Genomics UK (COG-UK) consortium, ; Volz, E.
10.1101/2021.01.18.427056 — bioinformatics — Posted on 2021-08-16
2041 A putative de novo evolved gene required for spermatid chromatin condensation in Drosophila melanogaster
Rivard, E. L.; Ludwig, A. G.; Patel, P. H.; Grandchamp, A.; Arnold, S. E.; Berger, A.; Scott, E. M.; Kelly, B. J.; Mascha, G. C.; Bornberg-Bauer, E.; Findlay, G. D.
10.1101/2021.06.10.447990 — genetics — Posted on 2021-08-15
2044 Respiratory Alkalosis Provokes Spike-Wave Discharges in Seizure- Prone Rats
Salvati, K.; Souza, G. M. P. R.; Lu, A. C.; Ritger, M. L.; Guyenet, P.; Abbott, S. B.; Beenhakker, M. P.
10.1101/2021.08.15.456408 — neuroscience — Posted on 2021-08-15
2045 Quaternary structure independent folding of voltage-gated ion channel pore domain subunits
Arrigoni, C.; Lolicato, M.; Shaya, D.; Rohaim, A.; Findeisen, F.; Colleran, C. M.; Dominik, P.; Kim, S. S.; Schuermann, J.; Kossiakoff, A. A.; Minor, D. L.
10.1101/2021.08.15.456357 — biophysics — Posted on 2021-08-15
2046 A nanopore ion source delivers single amino acid and peptide ions directly into the gas phase
Drachman, N.; LePoitevin, M.; Szapary, H.; Wiener, B.; Maulbetsch, W.; Stein, D.
10.1101/2021.08.15.456243 — biophysics — Posted on 2021-08-15
2047 Reconsidering the validity of transcriptome-wide association studies
de Leeuw, C.; Werme, J.; Savage, J.; Peyrot, W. J.; Posthuma, D.
10.1101/2021.08.15.456414 — genetics — Posted on 2021-08-15
2049 Hyperactive chemotaxis contributes to anti-TNFα treatment resistance in inflammatory bowel disease
Yau, T. O.; Vadakekolathu, J.; Foulds, G. A.; Du, G.; Polytarchou, C.; Dickins, B.; Rutella, S.
10.1101/2021.08.15.456400 — molecular biology — Posted on 2021-08-15
2050 Immune competence and spleen size scale with colony status in the naked mole-rat
Begay, V.; Cirovic, B.; Barker, A. J.; Klopfleisch, R.; Hart, D. W.; Bennett, N. C.; Lewin, G. R.
10.1101/2021.08.15.456351 — immunology — Posted on 2021-08-15
2051 Identification of synaptic PPT1 substrates highlight roles of depalmitoylation in disulfide bond formation and synaptic function
Gorenberg, E. L.; Tieze, S. M.; Yücel, B.; Zhao, H. R.; Chou, V.; Wirak, G. S.; Tomita, S.; Lam, T. T.; Chandra, S. S.
10.1101/2020.05.02.074302 — neuroscience — Posted on 2021-08-15
2055 Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine
Kishi, K. E.; Kim, Y. S.; Fukuda, M.; Kusakizako, T.; Thadhani, E.; Byrne, E. F. X.; Paggi, J. M.; Ramakrishnan, C.; Matsui, T. E.; Yamashita, K.; Nagata, T.; Konno, M.; Wang, P. Y.; Inoue, M.; Benster, T.; Uemura, T.; Liu, K.; Shibata, M.; Nomura, N.; Iwata, S.; Nureki, O.; Dror, R. O.; Inoue, K.; Deisseroth, K.; Kato, H. E.
10.1101/2021.08.15.456392 — biophysics — Posted on 2021-08-15
2056 Polymer microparticles prolong delivery of the 15-PGDH inhibitor SW033291
Dogan, A. B.; Rohner, N. A.; Smith, J. N. P.; Kilgore, J. A.; Williams, N. S.; Markowitz, S. D.; von Recum, H. A.; Desai, A. B.
10.1101/2021.08.15.456403 — bioengineering — Posted on 2021-08-15
2057 Strand asymmetry influences mismatch resolution during single-strand annealing
Pokusaeva, V. O.; Rosado Diez, A.; Espinar, L.; Filion, G. J.
10.1101/847160 — genomics — Posted on 2021-08-15
2058 An exon-intron split framework to prioritize miRNA-driven post-transcriptional regulatory signals and its application to study energy homeostasis in pigs
Marmol-Sanchez, E.; Cirera, S.; Zingaretti, L.; Jacobsen, M. J.; Ramayo-Caldas, Y.; Jorgensen, C. B.; Fredholm, M.; Cardoso, T. F.; Quintanilla, R.; Amills, M.
10.1101/2021.07.14.452370 — genomics — Posted on 2021-08-15
2060 Genetic parameters of colostrum and calf serum antibodies in Swedish dairy cattle
Cordero Solorzano, J. M.; de Koning, D. J.; Traven, M.; de Haan, T.; Jouffroy, M.; Larsson, A.; Myrthe, A.; Aarts, J.; Parmentier, H.; Bovenhuis, H.; Wensman, J. J.
10.1101/2021.08.08.455591 — genetics — Posted on 2021-08-15
2062 Diet-induced modifications to human microbiome reshape colonic homeostasis in irritable bowel syndrome
Pearl, A.; Bootz, H.; Melzer, E.; Sharon, E.; Abuchatzera, S.; Amidror, S.; Aretz, E.; Shoval, I.; Yaron, O.; Malnick, S.; Yissachar, N.
10.1101/2021.08.15.456374 — microbiology — Posted on 2021-08-15
2064 Reconfigurable asymmetric protein assemblies through implicit negative design
Sahtoe, D. D.; Praetorius, F.; Courbet, A.; Hsia, Y.; Wicky, B. I.; Edman, N. I.; Miller, L. M.; Timmermans, B. J.; Morris, H. M.; Kang, A.; Bera, A. K.; Baker, D.
10.1101/2021.08.15.456388 — synthetic biology — Posted on 2021-08-15
2065 Targeted Reactivation of X-linked Endogenous FOXP3 Gene from X-chromosome Inactivation in Human Female Breast Cancer Cells
Cui, X.; Xu, Z.; Wang, S.; Li, X.; Stringer-Reasor, E.; Bea, S.; Zeng, L.; Zhao, D.; Liu, R.; Qi, L. S.; Wang, L.
10.1101/2021.08.14.456310 — cancer biology — Posted on 2021-08-15
2069 ALGAEFUN with MARACAS, microALGAE FUNctional enrichment tool for MicroAlgae RnA-seq and Chip-seq AnalysiS
Romero-Losada, A. B.; Arvanitidou, C.; de los Reyes, P.; Garcia-Gonzalez, M.; Romero-Campero, F. J.
10.1101/2021.08.14.456338 — bioinformatics — Posted on 2021-08-15
2070 Analysis of genetic dominance in the UK Biobank
Palmer, D. S.; Zhou, W.; Abbott, L.; Baya, N.; Churchhouse, C.; Seed, C.; Poterba, T.; King, D.; Kanai, M.; Bloemendal, A.; Neale, B. M.
10.1101/2021.08.15.456387 — genetics — Posted on 2021-08-15
2071 The rs1421085 variant within FTO promotes but not inhibits thermogenesis and is potentially associated with human migration
Zhang, Z.; Chen, N.; Liu, R.; Yin, N.; He, Y.; Li, D.; Tong, M.; Gao, A.; Lu, P.; Li, H.; Zhang, D.; Gu, W.; Hong, J.; Wang, W.; Qi, L.; Wang, J.; Ning, G.
10.1101/2021.08.13.456245 — genetics — Posted on 2021-08-15
2073 Dynamics of transcription elongation are finely tuned by dozens of regulatory factors
Couvillion, M.; Harlen, K. M.; Lachance, K. C.; Trotta, K.; Smtih, E.; Brion, C.; Smalec, B. M.; Churchman, L. S.
10.1101/2021.08.15.456358 — molecular biology — Posted on 2021-08-15
2074 Insights into the nutritional properties and microbiome diversity in sweet and sour yogurt manufactured in Bangladesh
Islam, S. M. R.; Tanzina, A. Y.; Foysal, M. J.; Hoque, M. N.; SIDDIKI, A. Z.; Tay, A.; Hossain, S. M. J.; Bakar, M. A.; Mostafa, M.; Rumi, M. H.; Mannan, A.
10.1101/2021.08.15.456382 — microbiology — Posted on 2021-08-15
2075 Lupus Gut Microbiota Transplants Cause Autoimmunity and Inflammation
Ma, Y.; Guo, R.; Sun, Y.; Li, X.; He, L.; Li, Z.; Silverman, G. J.; Chen, G.; Gao, F.; Yuan, J.; Wei, Q.; Li, M.; Lu, L.; Niu, H.
10.1101/2021.08.15.456375 — immunology — Posted on 2021-08-15
2082 Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty, H.; Moberly, A. H.; Lohani, S.; Barson, D.; Coifman, R. R.; Mishne, G.; Cardin, J. A.; Higley, M. J.
10.1101/2021.08.15.456390 — neuroscience — Posted on 2021-08-15
2089 Deciphering Multi-way Interactions in the Human Genome
Lindsly, S. M.; Chen, C.; Dilworth, S.; Jeyarajan, S.; Stansbury, C.; Cicalo, A.; Meixner, W.; Beckloff, N.; Ryan, C.; Surana, A.; Omenn, G.; Muir, L.; Rajapakse, I.
10.1101/2021.08.15.456363 — bioinformatics — Posted on 2021-08-15
2094 AngioPlate - Biofabrication of perfusable complex tissues in multi-well plates with 4D subtractive manufacturing
Rajasekar, S.; Lin, D. S. Y.; Zhang, F.; Sotra, A.; Boshart, A.; Clotet-Freixas, S.; Liu, A.; Hirota, J. A.; Ogawa, S.; Konvalinka, A.; Zhang, B.
10.1101/2021.08.13.456244 — bioengineering — Posted on 2021-08-15
2096 Third Generation Cytogenetic Analysis (TGCA): diagnostic application of long-read sequencing.
Magini, P.; Mingrino, A.; Gega, B.; Mattei, G.; Semeraro, R.; Bolognini, D.; Mongelli, P.; Desiderio, L.; Pittalis, M. C.; Pippucci, T.; Magi, A.
10.1101/2021.08.13.456226 — genomics — Posted on 2021-08-15
2102 ELICE16INDURES (R): a plant immune-priming activator targeting jasmonate metabolism via TIFY and RHOMBOID proteins in Hordeum vulgare
Hegedus, G.; Kiniczky, M.; Nagy, A.; Pekker, P.; Lang, B.; Kleineizel, S.; Pallos, J. P.; Thomas-Nyari, Z.; Decsi, K.; Kutasy, B. J.; Szekvari, K.; Juhasz, A.; Virag, E.
10.1101/2021.08.11.455979 — plant biology — Posted on 2021-08-15
2108 Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection
Sasaki, Y.; Zhu, J.; Shi, Y.; Gu, W.; Kobe, B.; Ve, T.; DiAntonio, A.; Milbrandt, J.
10.1101/2021.07.15.452560 — neuroscience — Posted on 2021-08-15
2109 Age-related demethylation of the TDP-43 autoregulatory region in the human motor cortex
Koike, Y.; Sugai, A.; Hara, N.; Ito, J.; Yokoseki, A.; Ishihara, T.; Yamagishi, T.; Tsuboguchi, S.; Tada, M.; Ikeuchi, T.; Kakita, A.; Onodera, O.
10.1101/2021.01.13.426599 — molecular biology — Posted on 2021-08-15
2111 Evolutionary dynamics of sex-biased gene expression in a young XY system: Insights from the brown algae
Hatchett, W. J.; Jueterbock, A. O.; Kopp, M.; Coyer, J. A.; Coelho, S. M.; Hoarau, G. G.; Lipinska, A. P.
10.1101/2021.08.12.455804 — evolutionary biology — Posted on 2021-08-15
2112 Beyond fear centers: a distributed fMRI-based neuromarker for the subjective experience of fear
Zhou, F.; Zhao, W.; Qi, Z.; Geng, Y.; Yao, S.; Kendrick, K. M.; Wager, T. D.; Becker, B.
10.1101/2020.11.23.394973 — neuroscience — Posted on 2021-08-15
2117 Target Enrichment Enhances the Sensitivity of Sanger Sequencing for BRAF V600 Mutation Detection
Qan, Q.; Fu, A.; Liu, F.; Shen, S.; Jamba, M.; Liu, W.; Powell, M.; Zhang, A. A.; Sha, M.
10.1101/2021.08.14.456349 — molecular biology — Posted on 2021-08-15
2120 Gpnmb inhibits oligodendrocyte differentiation of adult neural stem cells by amplifying TGFβ1 signaling
Radecki, D. Z.; Wang, A. R.; Johnson, A. S.; Overman, C. A.; Thatcher, M. M.; Iyer, G.; Samanta, J.
10.1101/2021.08.13.456269 — neuroscience — Posted on 2021-08-14
2122 In vitro reconstitution demonstrates the amyloid-beta mediated myelin membrane deformation
Saleem, M.; Tiwari, A.; Pradhan, S.; Sannigrahi, A.; Jha, S.; Chattopadhyay, K.; Biswas, M.
10.1101/2021.08.13.456302 — biophysics — Posted on 2021-08-14
2132 NLRP1B and NLRP3 control the host response following colonization by the commensal protist Tritrichomonas musculis.
Chiaranunt, P.; Burrows, K.; Ngai, L.; Cao, E. Y.; Liang, H.; Streuker, C. J.; Girardin, S.; Mortha, A.
10.1101/2021.08.14.455483 — immunology — Posted on 2021-08-14
2133 Maternal γδ T Cells Shape Offspring Pulmonary Type-2 Immunity In A Microbiota-Dependent Manner
Papotto, P. H.; Yilmaz, B.; Pimenta, G.; Mensurado, S.; Cunha, C.; Fiala, G. J.; Gomes da Costa, D.; Goncalves-Sousa, N.; Chan, B. H. K.; Blankenhaus, B.; Carvalho, T.; Macpherson, A. J.; Allen, J. E.; Silva-Santos, B.
10.1101/2021.08.13.456265 — immunology — Posted on 2021-08-14
2136 Cortical hyperexcitability drives dying forward ALS symptoms and pathology in mice
Haidar, M.; Viden, A.; Cuic, B.; Wang, T.; Rosier, M.; Tomas, D.; Mills, S. A.; Govier-Cole, A.; Djouma, E.; Luikinga, S.; Rytova, V.; Barton, S. K.; Gonsalvez, D. G.; Palmer, L. M.; McLean, C.; Kiernan, M. C.; Vucic, S.; Turner, B. J.
10.1101/2021.08.13.456320 — neuroscience — Posted on 2021-08-14
2137 Mitochondrial interactome quantitation reveals structural changes in metabolic machinery in failing murine heart
Caudal, A.; Tang, X.; Chavez, J. D.; Keller, A.; Villet, O.; Zhou, B.; Walker, M. A.; Tian, R.; Bruce, J. E.
10.1101/2021.08.13.456027 — systems biology — Posted on 2021-08-14
2141 Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo
Clerk, A.; Meijles, D. N.; Hardyman, M. A.; Fuller, S. J.; Chothani, S. P.; Cull, J. J.; Cooper, S. T.; Alharbi, H. O.; Vanezis, K.; Felkin, L. E.; Markou, T.; Leonard, S. J.; Shaw, S. W.; Rackham, O. J.; Cook, S. A.; Glennon, P. E.; Sheppard, M. N.; Sembrat, J. C.; Rojas, M.; McTiernan, C. F.; Barton, P. J.; Sugden, P. H.
10.1101/2021.08.14.455637 — biochemistry — Posted on 2021-08-14
2144 Trichoderma asperellum: First report in Bangladesh
Uddin, S. A.; Hossain, I. -; Mahmud, H. -; Monjil, M. S.; Hossain, M. D.
10.1101/2021.08.13.456325 — molecular biology — Posted on 2021-08-14
2145 Structural and mechanistic basis of reiterative transcription initiation
Liu, Y.; Winkelman, J. T.; Yu, L.; Pukhrambam, C.; Firlar, E.; Kaelber, J. T.; Zhang, Y.; Nickels, B. E.; Ebright, R. H.
10.1101/2021.05.08.443277 — molecular biology — Posted on 2021-08-14
2149 Vesalius: Tissue anatomy from spatial transcriptomic data.
Martin, P. C. N.; Lövkvist, C.; Hong, B.-W.; Won, K. J.
10.1101/2021.08.13.456235 — genomics — Posted on 2021-08-14
2152 Network-based pathogenicity prediction for variants of uncertain significance
Kamada, M.; Takagi, A.; Kojima, R.; Tanaka, Y.; Nakatsui, M.; Tanabe, N.; Hirata, M.; Yoshida, T.; Okuno, Y.
10.1101/2021.07.15.452566 — genomics — Posted on 2021-08-14
2154 Fear memory-associated synaptic and mitochondrial changes revealed by deep learning-based processing of electron microscopy data
Liu, J.; Qi, J.; Chen, X.; Li, Z.; Hong, B.; Ma, H.; Li, G.; Shen, L.; Liu, D.; Kong, Y.; Xie, Q.; Han, H.; Yang, Y.
10.1101/2021.08.05.455246 — neuroscience — Posted on 2021-08-14
2160 CureSCi Metadata Catalog - Making sickle cell studies findable
Pan, H.; Ives, C.; Mandal, M.; Qin, Y.; Hendershot, T.; Brambilla, D.; Treadwell, M.; Wu, X.; Popovic, J.; Stratford, J.; Kroner, B.
10.1101/2021.08.13.456291 — bioinformatics — Posted on 2021-08-13
2162 Judgement Bias During Pregnancy In Domestic Pigs
Bushby, E. V.; Cotter, S.; Wilkinson, A.; Friel, M.; Collins, L.
10.1101/2021.08.13.456208 — animal behavior and cognition — Posted on 2021-08-13
2164 microRNA Expression Levels Change in Neonatal Patients During and After Exposure to Cardiopulmonary Bypass
Hsieh, L.; Tu, L.; Paquette, A. G.; Kibiryeva, N.; Marshall, J.; Bittel, D.; O'Brien, J.; Vickers, K.; Pastuszko, P.; Nigam, V.
10.1101/2021.08.13.454953 — developmental biology — Posted on 2021-08-13
2167 Metabolomics and Transcriptomics unravel the mechanism of browning resistance in Agaricus bisporus
Cai, Z.-X.; Chen, M.-Y.; Lu, Y.-P.; Guo, Z.-J.; Zeng, Z.-H.; Zheng, H.-Q.; Liao, J.-H.
10.1101/2021.08.13.456203 — microbiology — Posted on 2021-08-13
2168 A bacterium-like particle vaccine displaying Zika virus prM-E induces systemic immune responses in mice
Jin, H.; Bai, Y.; Wang, J.; Jiao, C.; Liu, D.; Zhang, M.; Li, E.; Huang, P.; Gong, Z.; Song, Y.; Xu, S.; Feng, N.; Zhao, Y.; Wang, T.; Li, N.; Gao, Y.; Yang, S.; Xia, X.; Wang, H.
10.1101/2021.08.13.456215 — microbiology — Posted on 2021-08-13
2173 INTEGRATE: Model-based multi-omics data integration to characterize multi-level metabolic regulation
Di Filippo, M.; Pescini, D.; Galuzzi, B. G.; Bonanomi, M.; Gaglio, D.; Mangano, E.; Consolandi, C.; Alberghina, L.; Vanoni, M.; Damiani, C.
10.1101/2021.08.13.456220 — systems biology — Posted on 2021-08-13
2176 Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of primary and metastatic hepatocellular carcinoma
Lozano, A.; Souche, F.-R.; Ramirez, C.; Vegna, S.; Desandre, G.; Riviere, A.; Dardalhon, V.; Zine El Aabidine, A.; Fort, P.; Akkari, L.; Hibner, U.; Gregoire, D.
10.1101/2021.08.13.456223 — cancer biology — Posted on 2021-08-13
2178 Measuring thousands of single vesicle leakage events reveals the mode of action of antimicrobial peptides
Al Nahas, K.; Fletcher, M.; Hammond, K.; Nehls, C.; Cama, J.; Ryadnov, M. G.; Keyser, U. F.
10.1101/2021.08.13.455434 — biophysics — Posted on 2021-08-13
2179 Evidence for the Presence of Hyphae and Fruiting Body Calcium Oxalate Crystallites in Schizophyllum commune
Xiao, X.; Huang, T.; zhang, j.; su, q.; Tao, L.; chen, x.; zhang, y.; Jiang, Y.; ding, y.; yu, x.; Liu, w.; Ji, H.; chi, s.
10.1101/2021.08.13.456293 — biochemistry — Posted on 2021-08-13
2181 Laboratory analysis of glucose, fructose, and sucrose contents in Japanese common beverages for the exact assessment of beverage-derived sugar intake
Ando, Y.; Ohta, Y.; Munetsuna, E.; Yamada, H.; Nouchi, Y.; Kageyama, I.; Mizuno, G.; Yamazaki, M.; Fujii, R.; Ishikawa, H.; Suzuki, K.; Ohashi, K.
10.1101/2021.08.13.456286 — biochemistry — Posted on 2021-08-13
2184 Assembled chromosomes of the blood fluke Schistosoma mansoni provide insight into the evolution of its ZW sex-determination system
Buddenborg, S. K.; Tracey, A.; Berger, D. J.; Lu, Z.; Doyle, S.; Fu, B.; Yang, F.; Reid, A. J.; Rodgers, F. H.; Rinaldi, G.; Sankaranarayanan, G.; Bohme, U.; Holroyd, N.; Berriman, M.
10.1101/2021.08.13.456314 — genomics — Posted on 2021-08-13
2187 Sequential in-cis mutagenesis in vivo reveals various functions for CTCF sites at the mouse HoxD cluster
Lhopitallier, R.; Beccari, L.; Lopez-Delisle, L.; Mascrez, B.; Zakany, J.; Gitto, S.; Duboule, D.
10.1101/2021.08.13.456193 — developmental biology — Posted on 2021-08-13
2191 A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis
Schiebel, E.; Zhang, W.; Khan, A.; Vitale, J.; Neuner, A.; Rink, K.; Luechtenborg, C.; Bruegger, B.; Soellner, T.
10.1101/2021.08.13.456248 — cell biology — Posted on 2021-08-13
2194 Multiple in vivo roles for the C-terminal domain of the RNA chaperone Hfq
Kavita, K.; Zhang, A.; Tai, C.-H.; Majdalani, N.; Storz, G.; Gottesman, S.
10.1101/2021.08.13.456236 — microbiology — Posted on 2021-08-13
2197 Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response
Ryan, D. G.; Knatko, E. V.; Casey, A.; Hukelmann, J. L.; Brenes, A. J.; Dayalan Naidu, S.; Higgins, M.; Tronci, L.; Nikitopoulou, E.; O'Neill, L. A.; Lamond, A. I.; Abramov, A. Y.; Cantrell, D. A.; Murphy, M. P.; Dinkova-Kostova, A. T.
10.1101/2021.08.13.456204 — immunology — Posted on 2021-08-13
2198 Across functional boundaries: making non-neutralizing antibodies to neutralize HIV-1 and mediate Fc-mediated effector killing of infected cells
Richard, J.; Nguyen, D.; Tolbert, W. D.; Gasser, R.; ding, s.; Vezina, D.; Yu Gong, S.; Prevost, J.; Gendron-Lepage, G.; Medjahed, H.; Gottumukkala, S.; Finzi, A.; Pazgier, M.
10.1101/2021.08.13.456231 — immunology — Posted on 2021-08-13
2199 Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins
Korona, D.; Dirnberger, B.; Giachello, C. N. G.; Queiroz, R. M. L.; Minde, D.-P.; Deery, M. J.; Johnson, G.; Mueller, K. H.; Firth, L. C.; Earley, F. G.; Russell, S.; Lilley, K. S.
10.1101/2021.08.13.456240 — neuroscience — Posted on 2021-08-13
2200 Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice
Berghoff, S.; Spieth, L.; Sun, T.; Hosang, L.; Depp, C.; Sasmita, A.; Vasileva, M.; Scholz, P.; Zhao, Y.; Krueger-Burg, D.; Wichert, S.; Brown, E.; Kyriakos, M.; Nave, K.-A.; Bonn, S.; Odoardi, F.; Rossner, M.; Ischebeck, T.; Edgar, J.; Saher, G.
10.1101/2021.08.13.456070 — neuroscience — Posted on 2021-08-13
2201 Engineering Bacillus subtilis for the formation of a durable living biocomposite material
Kang, S.-Y.; Pokhrel, A.; Bratsch, S.; Benson, J. J.; Seo, S.-O.; Quin, M. B.; Aksan, A.; Schmidt-Dannert, C.
10.1101/2021.08.13.456252 — synthetic biology — Posted on 2021-08-13
2203 Structural transitions in the GTP cap visualized by cryo-EM of catalytically inactive microtubules
LaFrance, B. J.; Roostalu, J.; Henkin, G.; Greber, B. J.; Zhang, R.; Normanno, D.; McCollum, C.; Surrey, T.; Nogales, E.
10.1101/2021.08.13.456308 — biophysics — Posted on 2021-08-13
2204 Non-Invasive Confocal Fluorescence Imaging of Mice Beyond 1700 nm Using Superconducting Nanowire Single-Photon Detectors
Wang, F.; Ren, F.; Ma, Z.; Qu, L.; Gourgues, R.; Xu, C.; Baghdasaryan, A.; Li, J.; Zadeh, I. E.; Los, J. W.; Fognini, A.; Qin-Dregely, J.; Dai, H.
10.1101/2021.08.13.456312 — biochemistry — Posted on 2021-08-13
2205 Caught in Motion: Human NTHL1 Undergoes Interdomain Rearrangement Necessary for Catalysis
Carroll, B. L.; Zahn, K. E.; Hanley, J. P.; Wallace, S. S.; Dragon, J. A.; Doublie, S.
10.1101/2021.08.13.456075 — biochemistry — Posted on 2021-08-13
2207 Helical Ordering of Envelope Associated Proteins and Glycoproteins in Respiratory Syncytial Virus Filamentous Virions
Conley, M. J.; Short, J. M.; Hutchings, J.; Burns, A. M.; Streetley, J.; Bakker, S. E.; Jaffery, H.; Stewart, M.; Power, B. J.; Zanetti, G.; Fearns, R.; Vijayakrishnan, S.; Bhella, D.
10.1101/2021.08.04.455049 — microbiology — Posted on 2021-08-13
2210 Leveraging a founder population to identify novel rare-population genetic determinants of lipidome
Montasser, M. E.; Aslibekyan, S.; Srinivasasainagendra, V.; Tiwari, H. K.; Patki, A.; Bagheri, M.; Kind, T.; Barupal, D.; Fan, S.; Perry, J. A.; Ryan, K. A.; Arnett, D. K.; Beitelshees, A. L.; Irvin, M. R.; O'Connell, J. R.
10.1101/2021.05.21.445208 — genetics — Posted on 2021-08-13
2211 A temporally controlled sequence of X-chromosomeinactivation and reactivation defines female mouse in vitro germ cells with meiotic potential
Severino, J.; Bauer, M.; Mattimoe, T.; Arecco, N.; Cozzuto, L.; Lorden, P.; Hamada, N.; Nosaka, Y.; Nagaoka, S.; Heyn, H.; Hayashi, K.; Saitou, M.; Payer, B.
10.1101/2021.08.11.455976 — developmental biology — Posted on 2021-08-13
2212 Mitofusins Mfn1 and Mfn2 are required in the β-cell to preserve mitochondrial architecture and insulin secretion
Georgiadou, E.; Muralidharan, C.; Martinez, M.; Chabosseau, P.; Tomas, A.; Wern, F. Y. S.; Akalestou, E.; Stylianides, T.; Wretland, A.; Legido-Quigley, C.; Jones, B.; Noriega, L.; Xu, Y.; Gu, G.; Alsabeeh, N.; Cruciani-Guglielmacci, C.; Magnan, C.; Ibberson, M.; Leclerc, I.; Ali, Y.; Soleimanpour, S. A.; Linnemann, A. K.; Rodriguez, T. A.; Rutter, G. A.
10.1101/2020.04.22.055384 — molecular biology — Posted on 2021-08-13
2214 Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility
Talwar, J.; Laub, D.; Pagadala, M.; Castro, A.; Lewis, M.; Luebeck, G. E.; Morris, G. P.; Salem, R. M.; Thompson, W. K.; Curtius, K.; Zanetti, M.; Carter, H.
10.1101/2021.08.12.456166 — cancer biology — Posted on 2021-08-13
2216 Nano-scale Architecture of Blood-Brain Barrier Tight-Junctions
Sasson, E.; Anzi, S.; Bell, B.; Yakovian, O.; Zorsky, M.; Deutsch, U.; Engelhardt, B.; Sherman, E.; Vatine, G. D.; Dzikowski, R.; Ben-Zvi, A.
10.1101/2021.08.12.456150 — cell biology — Posted on 2021-08-13
2217 Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution
Chen, D.; Ou, Z.; Zhu, J.; Ding, P.; Wang, H.; Luo, L.; Ding, X.; Lan, T.; Wu, W.; Yuan, Y.; Wu, W.; Qiu, J.; Zhu, Y.; Jia, Y.; Wei, Y.; Qin, Q.; Li, R.; Sun, C.; Zhao, W.; Lv, Z.; Pu, M.; Yang, S.; Chang, A.; Wei, X.; Chen, F.; Yang, T.; Wei, Z.; Yang, F.; Li, Y.; Hua, Y.; Liu, H.
10.1101/2021.08.13.456190 — cell biology — Posted on 2021-08-13
2218 A diabetic milieu increases cellular susceptibility to SARS-CoV-2 infections in engineered human kidney organoids and diabetic patients
Garreta, E.; Prado, P.; Stanifer, M. L.; Monteil, V.; Hurtado del Pozo, C.; Ullate-Agote, A.; Vilas-Zornoza, A.; Romero, J. P.; Jonsson, G.; Oria, R.; Leopoldi, A.; Hagelkrueys, A.; Moya-Rull, D.; Gonzalez, F.; Marco, A.; Tarantino, C.; Domingo-Pedrol, P.; HasanAli, O.; Ventura-Aguiar, P.; Campistol, J. M.; Prosper, F.; Mirazimi, A.; Boulant, S.; Penninger, J.; Montserrat, N.
10.1101/2021.08.13.456228 — cell biology — Posted on 2021-08-13
2220 Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant
Liu, Y.; Liu, J.; Johnson, B. A.; Xia, H.; Ku, Z.; Schindewolf, C.; Widen, S. G.; An, Z.; Weaver, S.; Menachery, V. D.; Xie, X.; Shi, P.-Y.
10.1101/2021.08.12.456173 — microbiology — Posted on 2021-08-13
2221 Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages
Kriplani, N.; Clohisey, S. M. R.; Fonseca, S.; Fletcher, S.; Lee, H.-M.; Ashworth, J.; Kurian, D.; Lycett, S. J.; Tait-Burkard, C.; Baillie, J. K.; Woolhouse, M. E. J.; Carding, S. R.; Stewart, J. P.; Digard, P.
10.1101/2021.08.13.456266 — microbiology — Posted on 2021-08-13
2222 Conserved T-cell epitopes predicted by bioinformatics in SARS-COV-2 variants
Lu, F.; Wang, S.; Wang, Y.; Yao, Y.; Wang, Y.; Liu, S.; Wang, Y.; Yu, Y.; Wang, L.
10.1101/2021.08.12.456182 — immunology — Posted on 2021-08-13
2223 Covid-19 vaccine immunogenicity in people living with HIV-1
Nault, L.; Marchitto, L.; Goyette, G.; Tremblay-Sher, D.; Fortin, C.; Martel-Laferriere, V.; Trottier, B.; Richard, J.; Durand, M.; Kaufmann, D. E.; Finzi, A.; Tremblay, C.
10.1101/2021.08.13.456258 — immunology — Posted on 2021-08-13
2224 SARS-CoV-2 Neutralization in Commercial Lots of Plasma-derived Immunoglobulin
Volk, A.; Covini-Souris, C.; Kuehnel, D.; de Mey, C.; Roemisch, J.; Schmidt, T.
10.1101/2021.08.13.456066 — immunology — Posted on 2021-08-13
2229 A Gene Replacement Humanization Platform for Rapid Functional Testing of Clinical Variants in Epilepsy-associated STXBP1.
McCormick, K.; Brock, T.; Wood, M.; Guo, L.; McBride, K.; Kim, C.; Resch, l.; Pop, S.; Bradford, C.; Kendrick, P.; Lawson, J. A.; Saunders, A.; McKeown, S.; Helbig, I.; Bainbridge, M. N.; Hopkins, C. E.
10.1101/2021.08.13.453827 — genetics — Posted on 2021-08-13
2235 Large-Scale Deep Multi-Layer Analysis of Alzheimer's Disease Brain Reveals Strong Proteomic Disease-Related Changes Not Observed at the RNA Level
Johnson, E. C. B.; Carter, E. K.; Dammer, E. B.; Duong, D.; Gerasimov, E. S.; Liu, Y.; Liu, J.; Betarbet, R.; Ping, L.; Yin, L.; Serrano, G. E.; Beach, T. G.; Peng, J.; De Jager, P. L.; Haroutunian, V.; Zhang, B.; Gaiteri, C.; Bennett, D. A.; Gearing, M.; Wingo, T. S.; Wingo, A. P.; Lah, J. J.; Levey, A. I.; Seyfried, N. T.
10.1101/2021.04.05.438450 — systems biology — Posted on 2021-08-13
2237 Large-Scale Analysis of Circulating Amino Acids and Gene Expression in Relation to Abdominal Obesity
Maltais-Payette, I.; Vijay, J.; Simon, M.-M.; Corbeil, J.; Briere, F.; Grundberg, E.; Tchernof, A.
10.1101/2020.11.19.388678 — physiology — Posted on 2021-08-13
2239 Refining Bulk Segregant Analyses: Ontology-Mediated Discovery of Flowering Time Genes in Brassica oleracea
Vos, R. A.; van der Veen-van Wijk, C. A. M.; Schranz, M. E.; Vrieling, K.; Klinkhamer, P. G. L.; Lens, F.
10.1101/2021.08.11.455982 — bioinformatics — Posted on 2021-08-13
2244 Masculinization of the X-chromosome in aphid soma and gonads
Jaquiery, J.; Simon, J.-C.; Robin, S.; Richard, G.; Peccoud, J.; Boulain, H.; Legeai, F.; Tanguy, S.; Prunier-Leterme, N.; Letrionnaire, G.
10.1101/2021.08.13.453080 — evolutionary biology — Posted on 2021-08-13
2246 The small and large intestine contain transcriptionally related mesenchymal stromal cell subsets that derive from embryonic Gli1+ mesothelial cells
Paerregaard, S. I.; Schussek, S.; Wulff, L.; Niss, K.; Moerbe, U.; Jendholm, J.; Wendland, K.; Andrusaite, A.; Brulois, K.; Nibbs, R.; Sitnik, K.; Mowat, A.; Butcher, E.; Brunak, S.; Agace, W. W.
10.1101/2021.08.13.456086 — developmental biology — Posted on 2021-08-13
2249 Transcriptional profiling of early differentiation of primary human mesenchymal stem cells into chondrocytes
Schwarzl, T.; Keogh, A.; Shaw, G.; Krstic, A.; Clayton, E.; Murphy, M.; Higgins, D. G.; Kolch, W.; Barry, F.
10.1101/2021.08.13.454287 — molecular biology — Posted on 2021-08-13
2250 Identification of a MarR subfamily that regulates arsenic resistance genes
Yu, Y.; Feng, R.; Chen, J.; Li, Y.; Liang, J.; Xie, Z.; Alwathnani, H. A.; Rosen, B. P.; Grove, A.; Chen, J.; Rensing, C.
10.1101/2021.08.12.456183 — microbiology — Posted on 2021-08-13
2252 Using OPMs to measure neural activity in standing, mobile participants
Seymour, R. A.; Alexander, N.; Mellor, S. J.; O'Neill, G. C.; Tierney, T. M.; Barnes, G. R.; Maguire, E. A.
10.1101/2021.05.26.445793 — neuroscience — Posted on 2021-08-13
2253 Enhanced negative response to stress following morphine administration increases wanting of social reward
Massaccesi, C.; Willeit, M.; Quednow, B. B.; Nater, U. M.; Lamm, C.; Mueller, D.; Silani, G.
10.1101/2021.08.13.456110 — neuroscience — Posted on 2021-08-13
2255 Humanoid robots are perceived as an evolutionary threat
Wei, Z.; Chen, Y.; Ren, J.; Piao, Y.; Zhang, P.; Zha, R.; Qiu, B.; Zhang, D.; Bi, Y.; Han, S.; Li, C.; Zhang, X.
10.1101/2021.08.13.456053 — neuroscience — Posted on 2021-08-13
2256 Temporal properties of painful contrast enhancement using repetitive stimulation
Szikszay, T. M.; Adamczyk, W. M.; Levenez, J. L. M.; Gouverneur, P.; Luedtke, K.
10.1101/2021.08.12.456139 — neuroscience — Posted on 2021-08-13
2261 Optimizing Polymerase Chain Reaction (PCR) using Machine Learning
Cordaro, N. J.; Kavran, A. J.; Smallegan, M.; Palacio, M.; Lammer, N.; Brant, T. S.; DuMont, V.; Doherty Garcia, N.; Miller, S.; Jourabchi, T.; Sawyer, S. L.; Clauset, A.
10.1101/2021.08.12.455589 — bioinformatics — Posted on 2021-08-13
2262 mebipred: identifying metal-binding potential in protein sequences.
Aptekmann, A. A.; Buongiorno, J.; Giovannelli, D.; Glamoclija, M.; Ferreiro, D. U.; Bromberg, Y.
10.1101/2021.08.12.456141 — bioinformatics — Posted on 2021-08-13
2265 An exon-intron split framework to prioritize miRNA-driven post-transcriptional regulatory signals and its application to study energy homeostasis in pigs
Marmol-Sanchez, E.; Cirera, S.; Zingaretti, L.; Jacobsen, M. J.; Ramayo-Caldas, Y.; Jorgensen, C. B.; Fredholm, M.; Cardoso, T. F.; Quintanilla, R.; Amills, M.
10.1101/2021.07.14.452370 — genomics — Posted on 2021-08-13
2267 Quantifying microbial associations of dissolved organic matter under global change
Hu, A.; Choi, M.; Tanentzap, A. J.; Liu, J.; Jang, K.-S.; Lennon, J. T.; Liu, Y.; Soininen, J.; Lu, X.; Zhang, Y.; Shen, J.; wang, j.
10.1101/2021.08.12.456177 — ecology — Posted on 2021-08-13
2270 Transcriptomic and functional analysis of Aβ1-42 oligomer-stimulated human monocyte-derived microglia-like cells
Smit, T.; Ormel, P. R.; Sluijs, J. A.; Hulshof, L. A.; Middeldorp, J.; de Witte, L. D.; Hol, E. M.; Donega, V.
10.1101/2021.08.12.456055 — neuroscience — Posted on 2021-08-13
2273 Precision environmental health monitoring by longitudinal exposome and multi-omics profiling
Gao, P.; Shen, X.; Zhang, X.; Jiang, C.; Zhang, S.; Zhou, X.; Rose, S. M. S.-F.; Snyder, M.
10.1101/2021.05.05.442855 — systems biology — Posted on 2021-08-13
2276 Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death
Law, M. E.; Yaaghubi, E.; Ghilardi, A.; Davis, B. J.; Ferreira, R. B.; Koh, J.; Chen, S.; DePeter, S. F.; Schilson, C. M.; Chiang, C.-W.; Heldermon, C. D.; Norgaard, P.; Castellano, R. K.; Law, B. K.
10.1101/2021.01.13.426390 — pharmacology and toxicology — Posted on 2021-08-13
2278 Mapping the peptide binding groove of MHC class I
Kopicki, J.-D.; Saikia, A.; Niebling, S.; Günther, C.; Garcia-Alai, M. M.; Springer, S.; Uetrecht, C.
10.1101/2021.08.12.455998 — biophysics — Posted on 2021-08-13
2285 RADseq data reveal a lack of admixture in a mouse lemur contact zone contrary to previous microsatellite results
Poelstra, J. W.; Montero, B. K.; Lüdemann, J.; Yang, Z.; Rakotondranary, S. J.; Hohenlohe, P.; Stetter, N.; Ganzhorn, J. U.; Yoder, A. D.
10.1101/2021.08.12.455854 — evolutionary biology — Posted on 2021-08-13
2286 The elevational ascent and spread of exotic annual grass dominance in the Great Basin, USA
Smith, J. T.; Allred, B. W.; Boyd, C. S.; Davies, K. W.; Jones, M. O.; Maestas, J. D.; Morford, S. L.; Naugle, D. E.; Kleinhesselink, A. R.
10.1101/2021.01.05.425458 — ecology — Posted on 2021-08-13
2289 Gut bacteria regulate the pathogenesis of Huntington's disease in Drosophila
Chongtham, A.; Yoo, J. H.; Chin, T. M.; Akingbesote, N. D.; Huda, A.; Khoshnan, A.
10.1101/2021.08.12.456124 — neuroscience — Posted on 2021-08-13
2291 Carbon Fiber Electrodes for Intracellular Recording and Stimulation
Huan, Y.; Gill, J. P.; Fritzinger, J. B.; Patel, P. R.; Richie, J. M.; della Valle, E.; Weiland, J. D.; Chestek, C. A.; Chiel, H. J.
10.1101/2021.08.12.456117 — neuroscience — Posted on 2021-08-13
2294 Safety Assessment of Broadband Laser Exposure in μOCT
Spicer, G. L. C.; Child, B.; Gardecki, J. A.; Kumar, A.; Wartak, A.; Gregg, A.; Leung, H. M.; Tearney, G. J.
10.1101/2021.08.12.455289 — biophysics — Posted on 2021-08-13
2298 Analysis of wild plant pathogen populations reveals a signal of adaptation in genes evolving for survival in agriculture in the beet rust pathogen (Uromyces beticola)
McMullan, M.; Percival-Alwyn, L.; Sawford, K.; Kaithakottil, G.; Grey, M.; Yvanne, H.; Low, R.; Warring, S.; Heavens, D.; Peel, N.; Kroboth, J.; Stevens, M.; Swarbreck, D.; Clark, M.; Hall, N.
10.1101/2021.08.12.456076 — evolutionary biology — Posted on 2021-08-13
2299 Deep Learning Classification of Lake Zooplankton
Kyathanahally, S. P.; Hardeman, T.; Merz, E.; Kozakiewicz, T.; reyes, M.; Isles, P.; Pomati, F.; Baity-Jesi, M.
10.1101/2021.08.12.455943 — ecology — Posted on 2021-08-13
2300 Next generation restoration metrics: Using soil eDNA bacterial community data to measure trajectories towards rehabilitation targets
Liddicoat, C.; Krauss, S. L.; Bissett, A.; Borrett, R. J.; Ducki, L. C.; Peddle, S. D.; Bullock, P.; Dobrowolski, M.; Grigg, A.; Tibbett, M.; Breed, M.
10.1101/2021.08.12.456018 — ecology — Posted on 2021-08-13
2301 Increases in multiple resources promote plant invasion
Zhang, Z.; Liu, Y.; Hardrath, A.; Jin, H.; van Kleunen, M.
10.1101/2021.08.12.456056 — ecology — Posted on 2021-08-13
2303 Phase transition specified by a binary code patterns the vertebrate eye cup
Balasubramanian, R.; Min, X.; Quinn, P. M. J.; Giudice, Q. L.; Tao, C.; Polanco, K.; Makrides, N.; Peregrin, J.; Bouaziz, M.; Mao, Y.; Wang, Q.; Costa, B. L.; Buenaventura, D.; Wang, F.; Ma, L.; Tsang, S. H.; Fabre, P. J.; Zhang, X.
10.1101/2021.08.12.455556 — developmental biology — Posted on 2021-08-13
2305 Sleep spindles, ripples, and interictal epileptiform discharges in the human anterior and mediodorsal thalamus
Szalardy, O.; Simor, P.; Ujma, P. P.; Jordan, Z.; Halasz, L.; Eross, L.; Fabo, D.; Bodizs, R.
10.1101/2021.08.12.456047 — neuroscience — Posted on 2021-08-13
2306 Cancer cell hyper-proliferation disrupts the topological invariance of epithelial monolayers
Roshal, D. S.; Martin, M.; Fedorenko, K.; MOLLE, V.; Baghdiguian, S.; Rochal, S. B.
10.1101/2021.08.12.455991 — biophysics — Posted on 2021-08-13
2310 N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2
Weiss, C. M.; Liu, H.; Ball, E. E.; Lam, S.; Hode, T.; Keel, M. K.; Levenson, R. M.; Coffey, L. L.
10.1101/2021.08.10.455872 — microbiology — Posted on 2021-08-13
2311 The Inherent Flexibility of Receptor Binding Domains in SARS-CoV-2 Spike Protein
Dokainish, H. M.; Re, S.; Mori, T.; Kobayashi, C.; Jung, J.; Sugita, Y.
10.1101/2021.08.06.455384 — biophysics — Posted on 2021-08-13
2313 Diversification by CofC and control by CofD govern biosynthesis and evolution of coenzyme F420 and its derivative 3PG-F420
Hasan, M.; Schulze, S.; Berndt, L.; Palm, G. J.; Braga, D.; Richter, I.; Last, D.; Lammers, M.; Lackner, G.
10.1101/2021.08.11.456035 — microbiology — Posted on 2021-08-13
2314 Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Zarei, I.; Koistinen, V. M.; Kokla, M.; Klavus, A.; Babu, A. F.; Lehtonen, M.; Auriola, S.; Hanhineva, K.
10.1101/2021.08.12.456100 — microbiology — Posted on 2021-08-13
2316 Selenium in wheat from farming to food
Wang, M.; Li, B.; Li, S.; Song, Z.; Kong, F.; Zhang, X.
10.1101/2021.07.17.452805 — plant biology — Posted on 2021-08-13
2317 MorphoGraphX 2.0: Providing context for biological image analysis with positional information
Strauss, S.; Runions, A.; Lane, B.; Eschweiler, D.; Bajpai, N.; Trozzi, N.; Routier-Kierzkowska, A.-L.; Yoshida, S.; Rodrigues da Silveira, S.; Vijayan, A.; Tofanelli, R.; Majda, M.; Echevin, E.; Le Gloanec, C.; Bertrand-Rakusova, H.; Adibi, M.; Schneitz, K.; Bassel, G.; Kierzkowski, D.; Stegmaier, J.; Tsiantis, M.; Smith, R. S.
10.1101/2021.08.12.456042 — developmental biology — Posted on 2021-08-13
2320 The Molecular Subtyping Resource (MouSR): a user-friendly tool for rapid biological discovery from human or mouse transcriptional data
Ahmaderaghi, B.; Amirkhah, R.; Jackson, J.; Lannagan, T.; Gilroy, K.; Malla, S.; Redmond, K.; Maughan, T.; Leedham, S.; Campbell, A.; Sansom, O.; Lawler, M.; Dunne, P. D.
10.1101/2021.08.12.456127 — bioinformatics — Posted on 2021-08-13
2323 Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine Approach
Sonnenkalb, L.; Carter, J.; Spitaleri, A.; Iqbal, Z.; Hunt, M.; Malone, K.; Utpatel, C.; Cirillo, D. M.; Rodrigues, C.; Nilgiriwala, K. S.; the CRyPTIC Consortium, ; Fowler, P. W.; Merker, M.; Niemann, S.
10.1101/2021.03.19.436148 — microbiology — Posted on 2021-08-13
2324 A 3D transcriptomics atlas of the mouse olfactory mucosa
Ruiz Tejada Segura, M. L.; Abou Moussa, E.; Garabello, E.; Nakahara, T. S.; Makhlouf, M.; Mathew, L. S.; Valle, F.; Huang, S. S. Y.; Mainland, J. D.; Caselle, M.; Osella, M.; Lorenz, S.; Reisert, J.; Logan, D. W.; Malnic, B.; Scialdone, A.; Saraiva, L. R.
10.1101/2021.06.16.448475 — neuroscience — Posted on 2021-08-13
2325 Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters
Palomer, E.; Martin-Flores, N.; Jolly, S.; Pascual-Vargas, P.; Benvegnu, S.; Podpolny, M.; Vaher, K.; Saito, T.; Sado, T. C.; Whiting, P.; Salinas, P. C.
10.1101/2021.05.19.444683 — neuroscience — Posted on 2021-08-13
2330 Balancing selection of the Intracellular Pathogen Response in natural Caenorhabditis elegans populations
van Sluijs, L.; Bosman, K. J.; Pankok, F.; Blokhina, T.; Wilten, J.; Riksen, J. A. G.; Snoek, B.; Pijlman, G. P.; Kammenga, J. E.; Sterken, M. G.
10.1101/579151 — genetics — Posted on 2021-08-13
2336 High molecular weight hyaluronan - a potential adjuvant to fluid resuscitation in porcine abdominal sepsis
Barrueta Tenhunen, A.; van der Heijden, J.; Weigl, W.; Frithiof, R.; Skorup, P.; Larsson, A.; Larsson, A.; Tenhunen, J.
10.1101/2021.08.12.456152 — pharmacology and toxicology — Posted on 2021-08-12
2337 Distinguishing and employing sister species of fish in assessment of stream quality
Van Dyke, F.; van Ee, B. W.; Harju, S.; Budi, J. W.; Sokolowski, T. B.; Keas, B.
10.1101/2021.08.12.456153 — bioinformatics — Posted on 2021-08-12
2339 New land use change scenarios for Brazil: refining global SSPs with a regional spatially-explicit allocation model
Silva Bezerra, F. G.; Von Randow, C.; Assis, T. O.; Bezerra, K. R. A.; Tejada, G.; Castro, A. A.; Gomes, D. M. d. P.; Avancini, R.; Aguiar, A. P.
10.1101/2021.08.12.456156 — ecology — Posted on 2021-08-12
2341 The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival
Inubushi, T.; Nakanishi, Y.; Abe, M.; Takahata, Y.; Nishimura, R.; Kurosaka, H.; Irie, F.; Yamashiro, T.; Yamaguchi, Y.
10.1101/2021.08.12.456060 — developmental biology — Posted on 2021-08-12
2342 Probing 3'UTRs as modular regulators of gene expression
Auxillos, J. Y.; Haynes, S. J.; Jain, A.; Alibert, C.; Danecka, W.; Wallace, E. W. J.
10.1101/2021.08.12.455418 — systems biology — Posted on 2021-08-12
2343 IWS1 phosphorylation by AKT3 controls nuclear export of type I IFN mRNAs and sensitivity to oncolytic viral infection, by regulating the alternative RNA splicing of U2AF2.
Laliotis, G. I.; Kenney, A.; Chavdoula, E.; Orlacchio, A.; Kaba, A. K.; La Ferlita, A.; Anastas, V.; Tsatsanis, C.; Beane, J. D.; Sehgal, L.; Coppola, V.; Yount, J. S.; Tsichlis, P. N.
10.1101/2020.12.26.424461 — cancer biology — Posted on 2021-08-12
2344 Mapping densely packed GPIIb/IIIa receptors in murine blood platelets with expansion microscopy
Heil, H. S.; Aigner, M.; Maier, S.; Gupta, P.; Evers, L. M. C.; Goeb, V.; Kusch, C.; Meub, M.; Nieswandt, B.; Stegner, D.; Heinze, K. G.
10.1101/2021.02.16.431449 — biophysics — Posted on 2021-08-12
2345 HIV-1 drug resistance profiling using amino acid sequence space cartography
Pikalyova, K.; Orlov, A.; Lin, A.; Tarasova, O.; Marcou, G.; Horvath, D.; Poroikov, V.; Varnek, A.
10.1101/2021.07.31.454569 — bioinformatics — Posted on 2021-08-12
2346 De novo chromosome level assembly of the mule deer (Odocoileus hemionus) genome
Lamb, S.; Taylor, A. M.; Hughes, T. A.; McMillan, B. R.; Larsen, R. T.; Khan, R.; Weisz, D.; Dudchenko, O.; Aiden, E. L.; Frandsen, P. B.
10.1101/2021.08.12.456132 — genomics — Posted on 2021-08-12
2347 Large-scale integration of DNA methylation and gene expression array platforms
Lancaster, E. E.; Vladimirov, V. I.; Riley, B. P.; Landry, J. W.; Roberson-Nay, R.; York, T. P.
10.1101/2021.08.12.455267 — genetics — Posted on 2021-08-12
2353 Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation
Yuan, S.; Hahn, S.; Miller, M. P.; Sanker, S.; Calderon, M.; Sullivan, M.; Dosunmu-Ogunbi, A.; Fazzari, M.; Li, Y.; Reynolds, M.; Wood, K.; St. Croix, C.; Stolz, D.; Cifuentes-Pagano, E.; Navas, P.; Shiva, S.; Schopfer, F. J.; Pagano, P. J.; Straub, A. C.
10.1101/2021.08.12.456058 — cell biology — Posted on 2021-08-12
2355 Matrix stiffness controls ciliogenesis and centriole position
Williantarra, I.; Leung, S.; Choi, Y. S.; Chhana, A.; McGlashan, S. R.
10.1101/2021.08.12.452439 — cell biology — Posted on 2021-08-12
2356 Worrying drives cell migration in mechanically unrestrained environments
Welf, E. S.; Driscoll, M. K.; Sapoznik, E.; Murali, V. S.; Weems, A. D.; Roh-Johnson, M.; Dean, K. M.; Fiolka, R. P.; Danuser, G.
10.1101/2020.11.09.372912 — cell biology — Posted on 2021-08-12
2357 A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein
Rick, T.; Kreiling, V.; Hoing, A.; Fiedler, S.; Glatter, T.; Steinchen, W.; Hochberg, G.; Bahre, H.; Seifert, R.; Bange, G.; Knauer, S. K.; Graumann, P. L.; Thormann, K. M.
10.1101/2021.08.12.456111 — microbiology — Posted on 2021-08-12
2359 Genome assemblies across the diverse evolutionary spectrum of Leishmania protozoan parasites
Warren, W. C.; Akopyants, N.; Dobson, D. E.; Hertz-Fowler, C.; Lye, L.-F.; Myler, P. J.; Ramasamy, G.; Shanmugasundram, A.; Silva-Franco, F.; Steinbiss, S.; Tomlinson, C.; Wilson, R. K.; Beverley, S. M.
10.1101/2021.05.29.446295 — microbiology — Posted on 2021-08-12
2360 Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement
Barrasso, K.; Chac, D.; Debele, M. D.; Geigel, C.; Harris, J. B.; LaRocque, R. C.; Midani, F. S.; Qadri, F.; Yan, J.; Weil, A. A.; Ng, W.-L.
10.1101/2021.02.01.429194 — microbiology — Posted on 2021-08-12
2362 Viral mimicry of p65/RelA transactivation domain to inhibit NF-κB activation
Dutra Albarnaz, J.; Ren, H.; Abreu Torres, A.; Shmeleva, E. V.; Melo, C. A.; Bannister, A. J.; Brember, M. P.; Chung, B. Y.- W.; Smith, G. L.
10.1101/2020.10.23.353060 — microbiology — Posted on 2021-08-12
2364 Streptococcus agalactiae MprF synthesizes a novel cationic glycolipid and contributes to brain entry and meningitis
Joyce, L. R.; Manzer, H. S.; da C. Mendonca, J.; Villarreal, R.; Doran, K. S.; Palmer, K. L.; Guan, Z.
10.1101/2020.12.01.406702 — microbiology — Posted on 2021-08-12
2366 Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells
Kirchhammer, N.; Trefny, M. P.; Natoli, M.; Bruecher, D.; Smith, S. N.; Werner, F.; Koch, V.; Schreiner, D.; Bartoszek, E.; Buchi, M.; Schmid, M.; Breu, D.; Hartmann, K. P.; Zaytseva, P.; Thommen, D. S.; Laubli, H.; Boettcher, J. P.; Stanczak, M. A.; Kashyap, A.; Plueckthun, A.; Zippelius, A.
10.1101/2021.05.27.445981 — immunology — Posted on 2021-08-12
2367 Peptidome profiling for the immunological stratification in sepsis: a proof of concept study
Ledesma, M.; Todero, M. F.; Maceira, L.; Prieto, M.; Vay, C.; Galas, M.; Lopez, B.; Yokobori, N.; Rearte, B.
10.1101/2020.12.29.424724 — immunology — Posted on 2021-08-12
2370 Clock time: a foreign measure to brain dynamics
van Bree, S.; Melcon, M.; Kolibius, L.; Kerren, C.; Wimber, M.; Hanslmayr, S.
10.1101/2021.06.09.447763 — neuroscience — Posted on 2021-08-12
2371 Peripheral sTREM2-related inflammatory activity alterations in early stage Alzheimer's disease
Weber, G. E.; Khrestian, M.; Tuason, E. D.; Shao, Y.; Pillai, J.; Rao, S.; Feng, H.; Zhou, Y.; Cheng, F.; DeSilva, T. M.; Stauffer, S.; Leverenz, J. B.; Bekris, L. M.
10.1101/2021.08.12.455916 — neuroscience — Posted on 2021-08-12
2372 Towards the Interpretability of Deep Learning Models for Human Neuroimaging
Hofmann, S. M.; Beyer, F.; Lapuschkin, S.; Markus, L.; Mueller, K.-R.; Villringer, A.; Samek, W.; Witte, A. V.
10.1101/2021.06.25.449906 — neuroscience — Posted on 2021-08-12
2374 Reconstructing transcriptional histories by CRISPR acquisition of retron-based genetic barcodes
Bhattarai-Kline, S.; Lockshin, E.; Schubert, M. G.; Nivala, J.; Church, G.; Shipman, S. L.
10.1101/2021.08.11.455990 — synthetic biology — Posted on 2021-08-12
2378 The longitudinal dynamics and natural history of clonal haematopoiesis
Fabre, M. A.; de Almeida, J. G.; Fiorillo, E.; Mitchell, E.; Damaskou, A.; Rak, J.; Orru, V.; Marongiu, M.; Vijayabaskar, M.; Baxter, J.; Hardy, C.; Abascal, F.; Chapman, M. S.; Williams, N.; Nangalia, J.; Martincorena, I.; Campbell, P.; McKinney, E.; Cucca, F.; Gerstung, M.; Vassiliou, G. S.
10.1101/2021.08.12.455048 — cancer biology — Posted on 2021-08-12
2380 Enhancing Sampling of Water Rearrangements on Ligand Binding: A Comparison of Techniques
Ge, Y.; Wych, D. C.; Samways, M. L.; Wall, M. E.; Essex, J. W.; Mobley, D. L.
10.1101/2021.06.14.448350 — biophysics — Posted on 2021-08-12
2381 Flanker: a tool for comparative genomics of gene flanking regions
Matlock, W.; Lipworth, S.; Constantinides, B.; Peto, T. E. A.; Walker, A. S.; Crook, D. W.; Hopkins, S.; Shaw, L. P.; Stoesser, N.
10.1101/2021.02.22.432255 — bioinformatics — Posted on 2021-08-12
2382 Supervised Learning Model Predicts Protein Adsorption to Carbon Nanotubes
Pinals, R. L.; Ouassil, N.; Del Bonis-O'Donnell, J. T.; Wang, J. W.; Landry, M. P.
10.1101/2021.06.19.449132 — bioengineering — Posted on 2021-08-12
2387 Mobile antimicrobial resistance genes in probiotics
Toth, A. G.; Csabai, I.; Judge, M. F.; Maroti, G.; Becsei, A.; Spisak, S.; Solymosi, N.
10.1101/2021.05.04.442546 — genomics — Posted on 2021-08-12
2389 Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans
Smith, H. J.; Lanjuin, A.; Sharma, A.; Prabhakar, A.; Tabakovic, E.; Sehgal, R.; Mair, W. B.
10.1101/2021.08.12.456148 — genetics — Posted on 2021-08-12
2391 Sclerostin Small Molecule Inhibitors Promote Osteogenesis by Activating Canonical Wnt and BMP Pathways
Sangadala, S.; Kim, C. H.; Fernandes, L. M.; Makkara, P.; Boden, S. D.; Beck, G. R.; Drissi, H.; Presciutti, S. M.
10.1101/2021.08.12.456145 — cell biology — Posted on 2021-08-12
2393 Sphingosine 1-Phosphate Mediates Adiponectin Receptor Signaling Essential For Lipid Homeostasis And Embryogenesis
Ruiz, M.; Devkota, R.; Panagaki, D.; Bergh, P.-O.; Kaper, D.; Henricsson, M.; Nik, A.; Petkevicius, K.; Hoog, J. L.; Bohlooly-Y, M.; Carlsson, P.; Boren, J.; Pilon, M.
10.1101/2021.08.12.456080 — cell biology — Posted on 2021-08-12
2395 Paramecium Polycomb Repressive Complex 2 physically interacts with the small RNA binding PIWI protein to repress transposable elements
Miro Pina, C.; Kawaguchi, T.; Charmant, O.; Michaud, A.; Cohen, I.; Humbert, A.; Jaszczyszyn, Y.; Del Maestro, L.; Holoch, D.; Ait-Si-Ali, S.; Arnaiz, O.; Raphael, M.; Duharcourt, S.
10.1101/2021.08.12.456067 — molecular biology — Posted on 2021-08-12
2396 Simultaneous infection with porcine reproductive and respiratory syndrome and influenza viruses abrogates clinical protection induced by live attenuated porcine reproductive and respiratory syndrome vaccination
Chrun, T.; Maze, E. A.; Vatzia, E.; Martini, V.; Paudyal, B.; Edmans, M.; Mcnee, A.; Manjegowda, T.; Salguero, F. J.; Wanasen, N.; Koonpaew, S.; Graham, S. P.; Tchilian, E.
10.1101/2021.08.12.456007 — immunology — Posted on 2021-08-12
2398 Reconstitution of monoterpene indole alkaloid biosynthesis in Nicotiana benthamiana
Dudley, Q. M.; Jo, S.; Serna Guerrero, D. A.; O'Connor, S. E.; Caputi, L.; Patron, N. J.
10.1101/2021.08.12.456143 — synthetic biology — Posted on 2021-08-12
2400 Overexpression of the SETD2 WW domain inhibits the phosphor-IWS1/SETD2 interaction and the oncogenic AKT/IWS1 RNA splicing program.
Laliotis, G. I.; Chavdoula, E.; Anastas, V.; Singh, S.; Kenney, A. I.; Achaya, S.; Yount, J. S.; Sehgal, L.; Tsichlis, P. N.
10.1101/2021.08.12.454141 — cancer biology — Posted on 2021-08-12
2401 Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants
McCallum, M.; Walls, A. C.; Sprouse, K. R.; Bowen, J. E.; Rosen, L.; Dang, H. V.; deMarco, A.; Franko, N.; Tilles, S. W.; Logue, J.; Miranda, M. C.; Ahlrichs, M.; Carter, L.; Snell, G.; Pizzuto, M. S.; Chu, H. Y.; Van Voorhis, W. C.; Corti, D.; Veesler, D.
10.1101/2021.08.11.455956 — immunology — Posted on 2021-08-12
2405 Hybrid immunity improves B cell frequency, antibody potency and breadth against SARS-CoV-2 and variants of concern
Andreano, E.; Paciello, I.; Piccini, G.; Manganaro, N.; Pileri, P.; Hyseni, I.; Leonardi, M.; Pantano, E.; Abbiento, V.; Benincasa, L.; Giglioli, G.; De Santi, C.; Fabbiani, M.; Rancan, I.; Tumbarello, M.; Montagnani, F.; Sala, C.; Montomoli, E.; Rappuoli, R.
10.1101/2021.08.12.456077 — immunology — Posted on 2021-08-12
2407 The Molecular Subtyping Resource (MouSR): a user-friendly tool for rapid biological discovery from human or mouse transcriptional data
Ahmaderaghi, B.; Amirkhah, R.; Jackson, J.; Lannagan, T.; Gilroy, K.; Malla, S.; Redmond, K.; Maughan, T.; Leedham, S.; Campbell, A.; Sansom, O.; Lawler, M.; Dunne, P. D.
10.1101/2021.08.12.456127 — bioinformatics — Posted on 2021-08-12
2408 Maximizing GWAS discovery and genomic prediction accuracy in Biobank data
Orliac, E. J.; Trejo Banos, D.; Ojavee, S. E.; Läll, K.; Mägi, R.; Visscher, P. M.; Robinson, M. R.
10.1101/2021.08.12.456099 — genomics — Posted on 2021-08-12
2409 Wnt16 exerts pleiotropic effects on bone and lean mass in zebrafish
Watson, C. J.; Morfin Montes de Oca, E.; Fiedler, I. A. K.; Cronrath, A. R.; Callies, L. K.; Swearer, A. A.; Sethuraman, V.; Ahmed, A.; Monstad-Rios, A. T.; Rojas, M. F.; Tang, W. J.; Gardiner, E. M.; Busse, B.; Hsu, Y.-H.; Kwon, R. Y.
10.1101/2021.08.12.456120 — genetics — Posted on 2021-08-12
2411 Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates
Corbett, K. S.; Gagne, M.; Wagner, D.; O'Connell, S.; Narpala, S. R.; Flebbe, D. R.; Andrew, S. F.; Davis, R. L.; Flynn, B.; Johnston, T. S.; Stringham, C.; Lai, L.; Valentin, D.; Van Ry, A.; Flinchbaugh, Z.; Werner, A. P.; Moliva, J. I.; Sriparna, M.; O'Dell, S.; Schmidt, S. D.; Tucker, C.; Choi, A.; Koch, M.; Bock, K. W.; Minai, M.; Nagata, B. M.; Alvarado, G. S.; Henry, A. R.; Laboune, F.; Schramm, C. A.; Zhang, Y.; Wang, L.; Choe, M.; Boyoglu-Barnum, S.; Shi, W.; Lamb, E.; Nurmukhambetova, S. T.; Provost, S. J.; Donaldson, M. M.; Marquez, J.; Todd, J.-P. M.; Cook, A.; Dodson, A.; Pekosz, A
10.1101/2021.08.11.456015 — immunology — Posted on 2021-08-12
2412 In vitro determination of inhibitory effects by humic substances complexing Zn and Se on SARS-CoV-2 virus replication
Palyi, B.; Kis, Z.; Hajdrik, P.; Kovacs, N. S.; Veres, D. S.; Szigeti, K.; Hegedus, I.; Kovacs, T. J.; Bergmann, R. K.; Mathe, D.
10.1101/2021.08.11.456012 — microbiology — Posted on 2021-08-12
2413 Robust and Functional Immunity up to 9 months after SARS-CoV-2 infection: a Southeast Asian longitudinal cohort
Vo, H. M. T.; Maestri, A.; Lay, S.; Sann, S.; Ya, N.; Sovann, L.; Sopheak, S.; Pean, P.; Auerswald, H.; Schwartz, O.; Bruel, T.; Heng, S.; Dussart, P.; Ly, S.; Duong, V.; Karlsson, E. A.; Cantaert, T.
10.1101/2021.08.12.455901 — immunology — Posted on 2021-08-12
2418 Selecting Clustering Algorithms for IBD Mapping
Shemirani, R.; Belbin, G. M.; Burghardt, K.; Lerman, K.; Avery, C. L.; Kenny, E. E.; Gignoux, C. R.; Ambite, J.
10.1101/2021.08.11.456036 — bioinformatics — Posted on 2021-08-12
2420 MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state
Mehravar, M.; Kumar, Y.; Olshansky, M.; Bansal, D.; Dent, C.; Hathiwala, D.; Zhang, Z.; Gandhi, H.; Fulcher, A.; Huang, C.; Price, J.; Arumugam, S.; Ceman, S.; Balasubramanian, S.; Papas, B. N.; Morgan, M.; Miska, E. A.; Schittenhelm, R. B.; Tripathi, P.; Das, P. P.
10.1101/2021.08.11.456030 — biochemistry — Posted on 2021-08-12
2423 Towards the extended barcode concept: Generating DNA reference data through genome skimming of danish plants
Chua, P. Y. S.; Leerhoi, F.; Langkjaer, E. M. R.; Margaryan, A.; Noer, C. L.; Richter, S. R.; Restrup, M. E.; Bruun, H. H.; Hartvig, I.; Coissac, E.; Boessenkool, S.; Alsos, I. G.; Bohmann, K.
10.1101/2021.08.11.456029 — genomics — Posted on 2021-08-12
2430 The absence of the autoimmune regulator gene (AIRE) impairs the three-dimensional structure of medullary thymic epithelial cell spheroids
Monteleone-Cassiano, A. C.; Dernowsek, J. A.; Mascarenhas, R. S.; Assis, A. F.; Pitol, D.; Issa, J. M.; Donadi, E. A.; Passos, G. A.
10.1101/2021.08.11.455994 — immunology — Posted on 2021-08-12
2431 Sulfonylureas target the neurovascular response to decrease Alzheimer's pathology
Macauley, S. L.; Stanley, M.; Caesar, E. E.; Moritz, W. R.; Bice, A. R.; Cruz-Diaz, N.; Carroll, C. M.; Day, S. M.; Grizzanti, J.; Mahan, T. E.; Snipes, J. A.; Orr, T. C.; Culver, J.; Remedi, M. S.; Nichols, C. G.; Karch, C.; Cox, L. A.; Diz, D. I.; Bauer, A. Q.; Holtzman, D. M.
10.1101/2021.08.11.455969 — neuroscience — Posted on 2021-08-12
2435 Androgen synthesis inhibition but not gonadectomy reduces persistence during strategy set-shifting and reversal learning in male rats
Tomm, R. J.; Seib, D. R.; Kachkovski, G. V.; Schweitzer, H. R.; Tobiansky, D. J.; Floresco, S. B.; Soma, K. K.
10.1101/2021.08.11.456005 — neuroscience — Posted on 2021-08-12
2437 A NOVEL PREGNANT RAT MODEL FOR LABOR INDUCTION AND AUGMENTATION WITH OXYTOCIN
Giri, T.; Jiang, J.; Xu, Z.; McCarthy, R.; Halabi, C.; Tycksen, E.; Cahill, A. G.; England, S. K.; Palanisamy, A.
10.1101/2021.08.11.455293 — pharmacology and toxicology — Posted on 2021-08-12
2438 Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis
Wu, X.; Lai, Y.; Chen, S.; Zhou, C.; Tao, C.; Li, J.; Fu, X.; Huang, J.; Tong, W.; Tian, H.; Shao, Z.; Liu, C.; Chen, D.; Bai, X.; Cao, H.; Xiao, G.
10.1101/2021.08.11.456023 — pathology — Posted on 2021-08-12
2442 Deep learning based behavioral profiling of rodent stroke recovery
Weber, R. Z.; Mulders, G.; Kaiser, J.; Tackenberg, C.; Rust, R.
10.1101/2021.08.11.455647 — neuroscience — Posted on 2021-08-12
2443 MODEL BASED OPTIMIZATION OF THE TERPENOIDS BIOSYNTHESIS IN E. coli
Alvarez-Vasquez, F.; Gonzalez-Alcon, C.; Gallego-Jara, J.; Puente, T. d. D.; Canovas, M.; Torres, N. V.
10.1101/2021.08.11.455928 — systems biology — Posted on 2021-08-12
2447 Decoding gene regulation in the fly brain
Janssens, J.; Aibar, S.; Taskiran, I. I.; Ismail, J. N.; Spanier, K. I.; Bravo Gonzalez-Blas, C.; Quan, X. J.; Papasokrati, D.; Hulselmans, G.; Makhzami, S.; De Waegeneer, M.; Christiaens, V.; Aerts, S.
10.1101/2021.08.11.454937 — genomics — Posted on 2021-08-12
2448 Global prevalence of potentially pathogenic short-tandem repeats in an epilepsy cohort
Moreau, C.; Michaud, J. L.; Hamdan, F. F.; Bouchard, J.; Tremblay, V.; Minassian, B. A.; Cossette, P.; Girard, S. L.
10.1101/2020.08.20.259168 — genetics — Posted on 2021-08-12
2450 The transmission of African Animal Trypanosomiasis (nagana) in two districts in the forest zone of Ghana
Tweneboah, A.; Rosenau, J.; Agyapong, A. K.; Addison, T. K.; Mahamat, I. A. M.; Weber, J. S.; Kelm, S.; Badu, K.
10.1101/2021.08.11.455898 — evolutionary biology — Posted on 2021-08-12
2452 Sticky Pi, an AI-powered smart insect trap for community chronoecology
Geissmann, Q.; Abram, P. K.; Wu, D.; Haney, C. H.; Carrillo, J.
10.1101/2021.08.11.455750 — ecology — Posted on 2021-08-12
2453 The spatio-temporal program of liver zonal regeneration
Ben-Moshe, S.; Veg, T.; Manco, R.; Dan, S.; Kolodziejczyk, A. A.; Bahar Halpern, K.; Elinav, E.; Itzkovitz, S.
10.1101/2021.08.11.455924 — cell biology — Posted on 2021-08-12
2454 Lipid and nucleocapsid N-protein accumulation in COVID-19 patient lung and infected cells
Grootemaat, A.; van der Niet, S.; Scholl, E. R.; Roos, E.; Schurink, B.; Bugiani, M.; Miller, S. E.; Larsen, P. W.; Pankras, J.; Reits, E. E.; van der Wel, N. N.
10.1101/2021.06.24.449252 — microbiology — Posted on 2021-08-12
2459 Performance of Core Genome Multilocus Sequence Typing Compared to Capillary-Electrophoresis PCR Ribotyping and SNP Analysis of Clostridioides difficile
Baktash, A.; Corver, J.; Harmanus, C.; Smits, W. K.; Fawley, W. N.; Wilcox, M. H.; Kumar, N.; Eyre, D. W.; Indra, A.; Mellmann, A.; Kuijper, E. J.
10.1101/2021.08.10.455895 — molecular biology — Posted on 2021-08-12
2460 MRG proteins are shared by multiple protein complexes with distinct functions
Devoucoux, M.; Roques, C.; Joly-Beauparlant, C.; Droit, A.; Hussein, S. M. I.; Cote, J.
10.1101/2021.08.11.456009 — molecular biology — Posted on 2021-08-12
2461 ELICE16INDURES (R): a plant immune-priming activator targeting jasmonate metabolism via TIFY and RHOMBOID proteins in Hordeum vulgare
Hegedus, G.; Kiniczky, M.; Nagy, A.; Pekker, P.; Lang, B.; Kleineizel, S.; Pallos, J. P.; Thomas-Nyari, Z.; Decsi, K.; Kutasy, B. J.; Szekvari, K.; Juhasz, A.; Virag, E.
10.1101/2021.08.11.455979 — plant biology — Posted on 2021-08-12
2463 CYFIP2-containing WAVE complexes inhibit cell migration by a competition mechanism
Polesskaya, A.; Boutillon, A.; Yang, S.; Wang, Y.; Romero, S.; Liu, Y.; Lavielle, M.; Vacher, S.; Schnitzler, A.; Molinie, N.; Rocques, N.; Fokin, A.; Guerois, R.; Bieche, I.; Chen, B.; David, N. B.; Gautreau, A. M.
10.1101/2020.07.02.184655 — cell biology — Posted on 2021-08-12
2464 Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells.
Noordstra, I.; van den Berg, C. M.; Boot, F. W. J.; Katrukha, E. K.; Yu, K. L.; Tas, R. P.; Portegies, S.; Viergever, B. J.; de Graaff, E.; Hoogenraad, C.; de Koning, E. J. P.; Carlotti, F.; Kapitein, L.; Akhmanova, A.
10.1101/2021.08.11.455909 — cell biology — Posted on 2021-08-12
2465 Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
Medina-Ruiz, L.; Bartolini, R.; Dyer, D. P.; Vidler, F.; Hughes, C.; Schuette, F.; Love, S.; Fu, J.; Stewart, A. F.; Graham, G. J.
10.1101/2021.08.11.455927 — immunology — Posted on 2021-08-12
2466 Diet effects on mouse meiotic recombination: a warning for recombination studies
Belmonte Tebar, A.; San Martin Perez, E.; Nam-Cha, S. H.; Soler Valls, A. J.; Singh, N. D.; de la Casa-Esperon, E.
10.1101/2021.05.12.443881 — genetics — Posted on 2021-08-12
2467 A temporally controlled sequence of X-chromosomeinactivation and reactivation defines female mouse in vitro germ cells with meiotic potential
Severino, J.; Bauer, M.; Mattimoe, T.; Arecco, N.; Cozzuto, L.; Lorden, P.; Hamada, N.; Nosaka, Y.; Nagaoka, S.; Heyn, H.; Hayashi, K.; Saitou, M.; Payer, B.
10.1101/2021.08.11.455976 — developmental biology — Posted on 2021-08-12
2468 Drug metabolism activity is a Critical Intrinsic Selector for Hepatocytes to elongate cell lifespan by using a cell-killing antibiotic
Akiyama, S.; Saku, N.; Miyata, S.; Ite, K.; Toyoda, M.; Kimura, T.; Kuroda, M.; Nakazawa, A.; Kasahara, M.; Nonaka, H.; Kamiya, A.; Kiyono, T.; Kobayshi, T.; Murakami, Y.; UMEZAWA, A.
10.1101/2021.04.18.440311 — cell biology — Posted on 2021-08-12
2469 Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes
Kim, A.; Knudsen, J. G.; Madara, J. C.; Benrick, A.; Hill, T.; Abdul Kadir, L.; Kellard, J. A.; Mellander, L.; Miranda, C.; Lin, H.; James, T.; Suba, K.; Spigelman, A.; Wu, Y.; MacDonald, P.; Wernstedt Asterholm, I.; Magnussen, T.; Christensen, M.; Vilsboll, T.; Salem, V.; Knop, F. K.; Rorsman, P.; Lowell, B. B.; Briant, L.
10.1101/2020.01.30.927426 — cell biology — Posted on 2021-08-12
2470 Genome organisation and evolution of a eukaryotic nicotinate co-inducible pathway
Bokor, E.; Flipphi, M.; Kocsube, S.; Amon, J.; Vagvolgyi, C.; Scazzocchio, C.; Hamari, Z.
10.1101/2021.04.19.440407 — microbiology — Posted on 2021-08-12
2476 LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants
Alasiri, A.; Karczewski, K. J.; Cole, B.; Loza, B.-L.; Moore, J. H.; van der Laan, S. W.; Asselbergs, F. W.; Keating, B. J.; van Setten, J.
10.1101/2021.08.09.455694 — bioinformatics — Posted on 2021-08-11
2477 Modular evolution of secretion systems and virulence plasmids in a bacterial species complex
Chou, L.; Lin, Y.-C.; Haryono, M.; Santos, M. N. M.; Cho, S.-T.; Weisberg, A. J.; Wu, C.-F.; Chang, J. H.; Lai, E.-M.; Kuo, C.-H.
10.1101/2021.05.20.444927 — genomics — Posted on 2021-08-11
2478 Protein prediction for trait mapping in diverse populations
Schubert, R.; Geoffroy, E.; Gregga, I.; Mulford, A.; Aguet, F.; Ardlie, K.; Gerszten, R.; Clish, C.; Van Den Berg, D.; Taylor, K.; Durda, P.; Johnson, C.; Cornell, E.; Guo, X.; Liu, Y.; Tracy, R.; Conomos, M.; Laurie, C.; Blackwell, T.; Papanicolaou, G.; Lappalainen, T.; Mikhaylova, A.; Thornton, T.; Cho, M.; Gignoux, C.; Lange, L.; Lange, E.; Rich, S.; Rotter, J.; Manichaikul, A.; Im, H. K.; Wheeler, H. E.
10.1101/2021.08.11.455912 — genomics — Posted on 2021-08-11
2481 Nuclear SUN1 stabilizes endothelial cell junctions to regulate blood vessel formation
Buglak, D. B.; Gold, A. L.; Marvin, A. P.; Ricketts, S. N.; Oatley, M.; Tanke, N. T.; Johnson, B. N.; Bautch, V. L.
10.1101/2021.08.11.455980 — cell biology — Posted on 2021-08-11
2482 Discovery of genes that modulate flavivirus replication in an interferon-dependent manner
Lesage, S.; Chazal, M.; Beauclair, G.; Batalie, D.; Couderc, E.; Lescure, A.; Del Nery, E.; Tangy, F.; Martin, A.; Manel, N.; jouvenet, n.
10.1101/2021.07.20.453077 — microbiology — Posted on 2021-08-11
2484 Testing covariance models for MEG source reconstruction of hippocampal activity
O'Neill, G. C.; Barry, D. N.; Tierney, T. M.; Mellor, S.; Maguire, E. A.; Barnes, G. R.
10.1101/2021.04.29.441929 — neuroscience — Posted on 2021-08-11
2486 PRC1 Sustains the Memory of Neuronal Fate Independent of PRC2 Function
Dasen, J.; Sawai, A.; Pfennig, S.; Bulajic, M.; Miller, A.; Khodadadi-Jamayran, A.; Mazzoni, E. O.
10.1101/2021.08.09.455667 — neuroscience — Posted on 2021-08-11
2488 Modeling progression of single cell populations through the cell cycle as a sequence of switches
Zinovyev, A.; Sadovsky, M.; Calzone, L.; Fouche, A.; Groeneveld, C. S.; Chervov, A.; Barillot, E.; Gorban, A. N.
10.1101/2021.06.14.448414 — systems biology — Posted on 2021-08-11
2489 Computational modeling and quantitative cell physiology reveal central parameters for the brassinosteroid-regulated cell growth of the Arabidopsis root
Grosseholz, R.; Wanke, F.; Gloeckner, N.; Rausch, L.; Rohr, L.; Scholl, S.; Scacchi, E.; Spazierer, A.-J.; Shabala, L.; Shabala, S.; Schumacher, K.; Kummer, U.; Harter, K. J. W.
10.1101/2021.04.13.439595 — plant biology — Posted on 2021-08-11
2491 Synergy of chemotherapy and macrophage depletion leads to B cell-mediated T cell memory activation and durable triple negative breast cancer regression
Singh, S.; Lee, N.; Bado, I.; Hamor, C.; Zhang, L.; Aguirre, S.; Hu, J.; Shen, Y.; Xu, Y.; Gao, Y.; Pedroza, D.; Zhan, N.; Chen, S.-H.; Wan, Y.-W.; Liu, Z.; Chang, J.; Hollern, D.; Perou, C.; Zhang, X.; Rosen, J. M.
10.1101/2021.02.22.432300 — cancer biology — Posted on 2021-08-11
2492 Mapping the genetic and environmental aetiology of autistic traits in Sweden and the United Kingdom
Reed, Z. E.; Larsson, H.; Haworth, C. M. A.; Rai, D.; Lundstrom, S.; Ronald, A.; Reichenberg, A.; Lichtenstein, P.; Davis, O. S. P.
10.1101/2020.04.14.031518 — genetics — Posted on 2021-08-11
2498 Complementary resource preferences spontaneously emerge in diauxic microbial communities
Wang, Z.; Goyal, A.; Dubinkina, V.; George, A. B.; Wang, T.; Fridman, Y.; Maslov, S.
10.1101/2021.03.16.435669 — ecology — Posted on 2021-08-11
2499 Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila
Logeay, R.; Geminard, C.; Lassus, P.; Kantar, D.; Heron-Milhavet, L.; Fischer, B.; Bray, S. J.; Colinge, J.; Djiane, A.
10.1101/2020.02.07.938621 — developmental biology — Posted on 2021-08-11
2501 Identification and characterization of distinct cell cycle stages in cardiomyocytes using the FUCCI transgenic system
Baniol, M.; Murganti, F.; Smialowska, A.; Panula, J.; Lazar, E.; Brockman, V.; Giatrellis, S.; Derks, W.; Bergmann, O.
10.1101/2021.08.11.455626 — cell biology — Posted on 2021-08-11
2507 Single-cell lineage trajectories and chromatin regulators that initialize antiviral CD8 T cell ontogeny
Diao, H.; Chen, R.; Tsuda, S. M.; Wang, D.; Frederick, M. A.; Kim, J.; Karunadharma, P.; Martinez, G.; Getzler, A. J.; Toma, C.; Milner, J.; Venables, T. C.; Martin, D. M.; Goldrath, A. W.; Crotty, S.; Pipkin, M. E.
10.1101/2021.08.11.456014 — immunology — Posted on 2021-08-11
2508 The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria
Wang, L. T.; Hurlburt, N. K.; Schon, A.; Flynn, B. J.; Pereira, L. S.; Dillon, M.; Flores-Garcia, Y.; Bonilla, B.; Zavala, F.; Idris, A. H.; Francica, J. R.; Pancera, M.; Seder, R. A.
10.1101/2021.08.11.455919 — immunology — Posted on 2021-08-11
2509 Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression
Meednu, N.; Rangel-Moreno, J.; Zhang, F.; Escalera-Rivera, K.; Corsiero, E.; Prediletto, E.; Dicarlo, E.; Goodman, S.; Donlin, L.; Raychaudhuri, S.; Bombardieri, M.; Pitzalis, C.; Orange, D.; AMP (RA/SLE) netwrok, ; McDavid, A.; Anolik, J. H.
10.1101/2021.05.14.443150 — immunology — Posted on 2021-08-11
2511 Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit
Yue, Y.; Xu, P.; Liu, Z.; Sun, X.; Su, J.; Du, H.; Chen, L.; Ash, R.; Smirnakis, S. M.; Simha, R.; Kusner, L.; Zeng, C.; Lu, H.
10.1101/786822 — neuroscience — Posted on 2021-08-11
2514 Soma and Neurite Density MRI (SANDI) of the in-vivo mouse brain
Ianus, A.; Carvalho, J.; Fernandes, F. F.; Cruz, R.; Chavarrias, C.; Palombo, M.; Shemesh, N.
10.1101/2021.08.11.455923 — neuroscience — Posted on 2021-08-11
2518 Early neutrophilia marked by aerobic glycolysis sustains host metabolism and delays cancer cachexia
Petruzzelli, M.; Ferrer, M.; Schuijs, M.; Hall, Z.; Perera, D.; Raghunathan, S.; Vacca, M.; Gaude, E.; Lukey, M. J.; Jodrell, D. I.; Frezza, C.; Wagner, E. F.; Janowitz, T.; Halim, T. Y. F.; Venkitaraman, A. R.
10.1101/2021.08.11.455851 — cancer biology — Posted on 2021-08-11
2519 Structural basis of adenylyl cyclase 9 activation
Qi, C.; Lavriha, P.; Mehta, V.; Khanppnavar, B.; Mohammed, I.; Li, Y.; Lazaratos, M.; Schaefer, J. V.; Dreier, B.; Plueckthun, A.; Bondar, A.-N.; Dessauer, C. W.; Korkhov, V. M.
10.1101/2021.08.11.455989 — biochemistry — Posted on 2021-08-11
2520 Whole genome analysis for 163 guide RNAs in Cas9 edited mice reveals minimal off-target activity
Peterson, K. A.; Khalouei, S.; Woodd, J. A.; Lanza, D. G.; Lintott, L. G.; Willis, B. J.; Seavitt, J. R.; Hanafi, N.; Braun, R. E.; Dickinson, M. E.; White, J. K.; Lloyd, K. C. K.; Heaney, J.; Murray, S. A.; Ramani, A.; Nutter, L. M.
10.1101/2021.08.11.455876 — genetics — Posted on 2021-08-11
2521 Evolution of olfactory receptors tuned to mustard oils in herbivorous Drosophilidae
Matsunaga, T.; Reisenman, C. E.; Goldman-Huertas, B.; Brand, P.; Miao, K.; Suzuki, H.; Verster, K. I.; Ramirez, S. R.; Whiteman, N. K.
10.1101/2019.12.27.889774 — evolutionary biology — Posted on 2021-08-11
2523 A temporally controlled sequence of X-chromosomeinactivation and reactivation defines female mouse in vitro germ cells with meiotic potential
Severino, J. R.; Bauer, M.; Mattimoe, T.; Arecco, N.; Cozzuto, L.; Lorden, P.; Hamada, N.; Nosaka, Y.; Nagaoka, S.; Heyn, H.; Hayashi, K.; Saitou, M.; Payer, B.
10.1101/2021.08.11.455976 — developmental biology — Posted on 2021-08-11
2524 Role of YAP in early ectodermal specification anda Huntington's Disease model of human neurulation
Piccolo, F. M.; Kastan, N. R.; Haremaki, T.; Tian, Q.; Laundos, T. L.; De Santis, R.; Carroll, T. S.; Luo, J.-D.; Gnedeva, K.; Etoc, F.; Hudspeth, A. J.; Brivanlou, A. H.
10.1101/2021.08.11.455964 — developmental biology — Posted on 2021-08-11
2525 Lineage-specific control of convergent differentiation by a Forkhead repressor
Mizeracka, K.; Rogers, J. M.; Rumley, J. D.; Shaham, S.; Bulyk, M. L.; Murray, J. I.; Heiman, M. G.
10.1101/758508 — developmental biology — Posted on 2021-08-11
2526 Rab11 endosomes coordinate centrosome number and movement following mitotic exit
Krishnan, N.; Swoger, M.; Bates, M.; Freshour, J.; Fioramonti, P.; Patteson, A. E.; Hehnly, H.
10.1101/2021.08.11.455966 — cell biology — Posted on 2021-08-11
2527 Drs2 regulates TRAPPIII in Atg9 transport: exposing the interplay of P4-ATPases and Multisubunit Tethering Complexes
Pazos, I.; Puig-Tinto, M.; Cordero, J.; Jimenez-Menendez, N.; Abella, M.; G. Duran, A.; Adachi-Fernandez, E.; Belmonte-Mateos, C.; Sabido-Bozo, S.; C. Hernandez, A.; Tosi, S.; Nezu, A.; Colombelli, J.; R. Graham, T.; Yoshimori, T.; Muniz, M.; Hamasaki, M.; Gallego, O.
10.1101/2020.12.25.417865 — cell biology — Posted on 2021-08-11
2530 Exon-Skipping Antisense Oligonucleotides for Cystic Fibrosis Therapy
Kim, Y. J.; Sivetz, N.; Layne, J.; Voss, D. M.; Yang, L.; Zhang, Q.; Krainer, A. R.
10.1101/2021.08.11.455936 — molecular biology — Posted on 2021-08-11
2531 Molecular dynamics and theratyping in airway and gut organoids reveal R352Q-CFTR conductance defect
Wong, S. L.; Awatade, N. T.; Astore, M. A.; Allan, K. M.; Carnell, M. J.; Slapetova, I.; Chen, P.-c.; Setiadi, J.; Pandzic, E.; Fawcett, L. K.; Widger, J. R.; Whan, R. M.; Griffith, R.; Ooi, C. Y.; Kuyucak, S.; Jaffe, A.; Waters, S.
10.1101/2021.08.11.456003 — molecular biology — Posted on 2021-08-11
2533 Identification of the 216kbp gene cluster and structure elucidation of gargantulides B and C, new complex 52-membered macrolides from Amycolatopsis sp.
Carretero-Molina, D.; Ortiz-Lopez, F. J.; Gren, T.; Oves-Costales, D.; Martin, J.; Roman-Hurtado, F.; Jorgensen, T. S.; de la Cruz, M.; Diaz, C.; Vicente, F.; Blin, K.; Reyes, F.; Weber, T.; Genilloud, O.
10.1101/2021.08.11.455926 — microbiology — Posted on 2021-08-11
2534 CsrA-controlled proteins important for Acinetobacter baumannii desiccation tolerance
Oda, Y.; Shapiro, M. M.; Lewis, N. M.; Zhong, X.; Huse, H. K.; Bruce, J. E.; Manoil, C.; Harwood, C. S.
10.1101/2021.08.11.455981 — microbiology — Posted on 2021-08-11
2535 Durability of SARS-CoV-2-specific T cell responses at 12-months post-infection
Lu, Z.; Laing, E. D.; Pena-Damata, J.; Pohida, K.; Tso, M. S.; Samuels, E. C.; Epsi, N. J.; Dorjbal, B.; Lake, C.; Richard, S. A.; Maves, R. C.; Lindholm, D. A.; Rozman, J.; English, C.; Huprikar, N.; Mende, K.; Colombo, R. E.; Colombo, C. J.; Broder, C. C.; Ganesan, A.; Lanteri, C. A.; Agan, B. K.; Tribble, D.; Simons, M. P.; Dalgard, C. L.; Blair, P. W.; Chenoweth, J.; Pollett, S. D.; Snow, A. L.; Burgess, T. H.; Malloy, A. M.
10.1101/2021.08.11.455984 — immunology — Posted on 2021-08-11
2536 The Role of State Uncertainty in the Dynamics of Dopamine
Mikhael, J. G.; Kim, H. R.; Uchida, N.; Gershman, S. J.
10.1101/805366 — neuroscience — Posted on 2021-08-11
2537 Reconstructing transcriptional histories by CRISPR acquisition of retron-based genetic barcodes
Bhattarai-Kline, S.; Lockshin, E.; Schubert, M. G.; Nivala, J.; Church, G.; Shipman, S. L.
10.1101/2021.08.11.455990 — synthetic biology — Posted on 2021-08-11
2539 Essential Loop Dynamics Modulates Catalytic Activity in α-Chymotrypsin
Biswas, P.; Pal, U.; Adhikari, A.; Mondal, S.; Ghosh, R.; Mukherjee, D.; Saha-Dasgupta, P. D. T.; Choudhury, D. S. S.; Das, P. D. R.; Pal, S. K.
10.1101/2021.08.11.455937 — biophysics — Posted on 2021-08-11
2544 SATB1 undergoes isoform-specific phase transitions in T cells
Zelenka, T.; Tzerpos, P.; Panagopoulos, G.; Tsolis, K.; Papamatheakis, D.-A.; Papadakis, V. M.; Stanek, D.; Spilianakis, C.
10.1101/2021.08.11.455932 — molecular biology — Posted on 2021-08-11
2546 Altered sleep intensity upon DBS to hypothalamic sleep-wake centers in rats
Masneuf, S.; Imbach, L. L.; Buechele, F.; Colacicco, G.; Penner, M.; Moreira, C. G.; Ineichen, C.; Jahanshahi, A.; Temel, Y.; Baumann, C. R.; Noain, D.
10.1101/2021.08.11.455908 — neuroscience — Posted on 2021-08-11
2551 DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling
Kim, S. S.; Kycia, I.; Karski, M.; Ma, R. K.; Bordt, E. A.; Kwan, J.; Karki, A.; Winter, E.; Aktas, R. G.; Wu, Y.; Emili, A.; Bauer, D. E.; Sethupathy, P.; Vakili, K.
10.1101/2021.08.11.455931 — cancer biology — Posted on 2021-08-11
2556 Molecular mimicry between Spike and human thrombopoietin may induce thrombocytopenia in COVID-19
Nunez-Castilla, J.; Stebliankin, V.; Baral, P.; Balbin, C. A.; Sobhan, M.; Cickovski, T.; Mondal, A. M.; Narasimhan, G.; Chapagain, P.; Mathee, K.; Siltberg-Liberles, J.
10.1101/2021.08.10.455737 — bioinformatics — Posted on 2021-08-11
2557 Defining the pig microglial transcriptome reveals their core signature, regional heterogeneity, and similarity with humans
Shih, B.; Brown, S. M.; Lefevre, L.; Mabbott, N. A.; Priller, J.; Thompson, G.; Lawrence, A. B.; McColl, B. W.
10.1101/2021.08.11.454467 — bioinformatics — Posted on 2021-08-11
2559 A global survey of specialized metabolic diversity encoded in bacterial genomes
Gavriilidou, A.; Kautsar, S. A.; Zaburannyi, N.; Krug, D.; Mueller, R.; Medema, M. H.; Ziemert, N.
10.1101/2021.08.11.455920 — genomics — Posted on 2021-08-11
2560 Multiplexed detection of SARS-CoV-2 genomic and subgenomic RNA using in situ hybridization
Acheampong, K. K.; Schaff, D. L.; Emert, B. L.; Lake, J.; Reffsin, S.; Shea, E. K.; Comar, C. E.; Litzky, L. A.; Khurram, N. A.; Linn, R. L.; Feldman, M.; Weiss, S. R.; Montone, K. T.; Cherry, S.; Shaffer, S. M.
10.1101/2021.08.11.455959 — microbiology — Posted on 2021-08-11
2561 N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2
Weiss, C. M.; Liu, H.; Ball, E. E.; Lam, S.; Hode, T.; Keel, M. K.; Levenson, R. M.; Coffey, L. L.
10.1101/2021.08.10.455872 — microbiology — Posted on 2021-08-11
2562 SARS-CoV-2 Spike Affinity and Dynamics Exclude the Strict Requirement of an Intermediate Host
Castelli, M.; Scietti, L.; Clementi, N.; Cavallaro, M.; Faravelli, S.; Pinnola, A.; Criscuolo, E.; Diotti, R. A.; Clementi, M.; Forneris, F.; Mancini, N.
10.1101/2021.08.11.455960 — microbiology — Posted on 2021-08-11
2563 Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants
McCallum, M.; Walls, A. C.; Sprouse, K. R.; Bowen, J. E.; Rosen, L.; Dang, H. V.; deMarco, A.; Franko, N.; Tilles, S. W.; Logue, J.; Miranda, M. C.; Ahlrichs, M.; Carter, L.; Snell, G.; Pizzuto, M. S.; Chu, H. Y.; Van Voorhis, W. C.; Corti, D.; Veesler, D.
10.1101/2021.08.11.455956 — immunology — Posted on 2021-08-11
2564 A single shot of a hybrid hAdV5-based anti-COVID-19 vaccine induces a long-lasting immune response and broad coverage against VOC
Lopez, M. V.; Vinzon, S. E.; Cafferata, E. G. A.; Nunez, F. J.; Soto, A.; Sanchez-Lamas, M.; Afonso, J.; Aguilar-Cortes, D.; Rios, G. D.; Maricato, J. T.; Torres-Braconi, C.; Barbosa-da Silveira, V.; Montes-de Andrade, T.; Carvalho-de Souza Bonetti, T.; Ramos Janini, L. M.; Castello Girao, M. J. B.; Llera, A. S.; Gomez, K.; Hortega, H. H.; Berguer, P. M.; Podhajcer, O. L.
10.1101/2021.08.11.455942 — immunology — Posted on 2021-08-11
2566 CytokineLink: a cytokine communication map to analyse immune responses in inflammatory and infectious diseases
Olbei, M. L.; Thomas, J.; Hautefort, I.; Treveil, A.; Bohar, B.; Madgwick, M.; Potari-Gul, L.; Csabai, L.; Modos, D.; Korcsmaros, T.
10.1101/2021.08.10.455874 — bioinformatics — Posted on 2021-08-11
2567 Pout2Prot: an efficient tool to create protein (sub)groups from Percolator output files
Van Den Bossche, T.; Schallert, K.; Verschaffelt, P.; Mesuere, B.; Benndorf, D.; Martens, L.
10.1101/2021.08.11.455803 — bioinformatics — Posted on 2021-08-11
2569 The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen
Malta, T. M.; Sabedot, T. S.; Datta, I.; Garofano, L.; Vallentgoed, W.; Varn, F. S.; Aldape, K.; D'Angelo, F.; Bakas, S.; Barnholtz-Sloan, J. S.; Gan, H. K.; Hasanain, M.; Hau, A.-C.; Johnson, K. C.; Khasraw, M.; Kocakavuk, E.; Kouwenhoven, M. C.; Migliozzi, S.; Niclou, S.; Niers, J. M.; Ormond, D. R.; Paek, S. H.; Reifenberger, G.; Smitt, P. A. S.; Smits, M.; Stead, L. F.; van den Bent, M. J.; Van Meir, E. G.; Walenkamp, A.; Weiss, T.; Weller, M.; Westerman, B. A.; Ylstra, B.; Wesseling, P.; Lasorella, A.; French, P.; Poisson, L. M.; The GLASS Consortium, ; Verhaak, R.; Iavarone, A.; Noushme
10.1101/2021.08.09.455687 — genomics — Posted on 2021-08-11
2570 Pathological LSD1 mutations cause HDAC-mediated aberrant gene repression during early cell differentiation
Bunina, D.; Germain, P.-L.; Lopez Tobon, A.; Fernandez-Novel Marx, N.; Arnold, C.; O hEachteirn, A.; Claringbould, A.; Lai, M. C.; Rangasamy, S.; Narayanan, V.; Testa, G.; Zaugg, J. B.; Noh, K.-M.
10.1101/2021.08.11.455900 — genomics — Posted on 2021-08-11
2571 Opportunistic gut sampling indicates differential diet and plastic ingestion risk in Indian dugongs
Prajapati, S.; Ghanekar, C.; Pathan, S.; Shekar, R.; Magesh, K. M.; Gole, S.; Bose, S.; Iyer, S.; Pande, A.; Johnson, J. A.; Kuppusamy, S.
10.1101/2021.08.11.455764 — ecology — Posted on 2021-08-11
2573 Long-term Transverse Imaging of the Hippocampus with Glass Microperiscopes
Redman, W. T.; Wolcott, N. S.; Montelisciani, L.; Luna, G.; Marks, T. D.; Sit, K. K.; Yu, C.-H.; Smith, S. L.; Goard, M. J.
10.1101/2021.08.10.455885 — neuroscience — Posted on 2021-08-11
2580 The virulome of Streptomyces scabiei in response to cello-oligosaccharides elicitors
Deflandre, B.; Stulanivic, N.; Planckaert, S.; Anderssen, S.; Bonometti, B.; Karim, L.; Coppieters, W.; Devreese, B.; Rigali, S.
10.1101/2021.08.10.455888 — microbiology — Posted on 2021-08-11
2581 LACK OF EVIDENCE FOR A VIABLE MICROBIOTA IN MURINE AMNIOTIC FLUID
Winters, A. D.; Romero, R.; Greenberg, J. M.; Galaz, J.; Shaffer, Z. D.; Garcia-Flores, V.; Kracht, D. J.; Gomez-Lopez, N.; Theis, K. R.
10.1101/2021.08.10.455893 — microbiology — Posted on 2021-08-11
2582 Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response
Webster, H. C.; Gamino, V.; Shergold, A. L.; Andrusaite, A. T.; Heieis, G. A.; Milling, S. W. F.; Maizels, R. M.; Perona-Wright, G.
10.1101/2021.08.10.455867 — immunology — Posted on 2021-08-11
2584 Dopamine D3 Receptor Ligand Suppresses the Expression of Levodopa-Induced Dyskinesia in Nonhuman Primate Model of Parkinson's Disease
Oh, T.; Daadi, E. S.; Kim, J.; Daadi, E. W.; Chen, P.-J.; Roy-Choudhury, G.; Bohmann, J.; Blass, B. E.; Daadi, M. M.
10.1101/2021.08.10.455884 — neuroscience — Posted on 2021-08-11
2585 Cortical efficient coding dynamics shape behavioral performance.
Angeloni, C. F.; Mlynarski, W.; Piasini, E.; Williams, A. M.; Wood, K. C.; Garami, L.; Hermundstad, A.; Geffen, M. N.
10.1101/2021.08.11.455845 — neuroscience — Posted on 2021-08-11
2586 Crosstalk between Ethylene and ABA during changes in soil water content reveals a role of ACC in coffee anthesis regulation
Lopez, M. E.; Silva Santos, I.; Marquez Gutierrez, R.; Jaramillo Mesa, A.; Cardon, C. H.; Espindola Lima, J. M.; Almeida Lima, A.; Chalfun-Junior, A.
10.1101/2021.08.10.455871 — plant biology — Posted on 2021-08-11
2587 SCL28 promotes cell expansion and endoreplication in Arabidopsis by activating SIAMESE-RELATED cyclin-dependent kinase inhibitors.
Goldy, C.; Barrera, V. L.; Taylor, I.; Buchensky, C.; Vena, R.; Benfey, P.; De Veylder, L.; Rodriguez, R. E.
10.1101/2021.08.10.455231 — plant biology — Posted on 2021-08-11
2589 Parent-of-origin effects propagate through networks to shape metabolic traits
Macias-Velasco, J. F.; St. Pierre, C. L.; Wayhart, J. P.; Yin, L.; Spears, L.; Miranda, M. A.; Carson, C.; Funai, K.; Cheverud, J. M.; Semenkovich, C. F.; Lawson, H. A.
10.1101/2021.08.10.455860 — genomics — Posted on 2021-08-11
2590 HDAC9 structural variants disrupting TWIST1 transcriptional regulation lead to craniofacial and limb malformations
Hirsch, N.; Dahan, I.; Dhaene, E.; Avni, M.; Vergult, S.; Vidal Garcia, M.; Magini, P.; Graziano, C.; Severi, G.; Bonora, E.; Nardone, A. M.; Brancati, F.; Fernandez-Jaen, A.; Olson, R. J.; Hallgrimsson, B.; Birnbaum, R. Y.
10.1101/2021.08.10.455254 — genomics — Posted on 2021-08-11
2591 Structure-function analysis of distant diphtheria toxin homologs reveals insights into host adaptation
Sugiman-Marangos, S. N.; Gill, S. K.; Mansfield, M. J.; Orrell, K. E.; Doxey, A. C.; Melnyk, R. A.
10.1101/2021.08.10.455837 — microbiology — Posted on 2021-08-11
2598 The Role of Low Molecular Weight Fungal Metabolites in Grapevine Trunk Disease Pathogenesis: Eutypa Dieback and Esca
Perez-Gonzalez, G.; Sebestyen, D.; Petit, E.; Jellison, J.; Mugnai, L.; Gelhaye, E.; Lee, N.; Farine, S.; Bertsch, C.; Goodell, B.
10.1101/2021.08.09.455770 — microbiology — Posted on 2021-08-11
2599 Liver Organoid and T Cell Coculture Models Cytotoxic T Cell Responses against Hepatitis C Virus
Natarajan, V.; Simoneau, C. R.; Erickson, A.; Meyers, N. L.; Baron, J. L.; Cooper, S.; Ott, M.; McDevitt, T. C.
10.1101/2021.08.10.455738 — immunology — Posted on 2021-08-11
2603 MAP4K4 determines cancer cell phenotype by controlling the plasma membrane-associated proteome
Capdeville, C.; Russo, L.; Penton, D.; Migliavacca, J.; Zecevic, M.; Gries, A.; Neuhauss, S. C. F.; Grotzer, M.; Baumgartner, M.
10.1101/2021.08.10.455785 — cell biology — Posted on 2021-08-11
2604 Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites
Ashraf, K.; Tajeri, S.; Arnold, C.-S.; Amanzougaghene, N.; Franetich, J.-F.; Vantaux, A.; Soulard, V.; Bordessoulles, M.; Cazals, G.; Bousema, T.; van Gemert, G.-J.; Le Grand, R.; Dereuddre-Bosquet, N.; Barale, J.-C.; Witkowski, B.; Snounou, G.; Duval, R.; Botte, C.; Mazier, D.
10.1101/2021.08.10.455849 — microbiology — Posted on 2021-08-11
2605 Natural reassortment of a segmented RNA arbovirus illustrates plasticity of phenotype in the arthropod vector and mammalian host in vivo
Sanders, C. J.; Veronesi, E.; Rajko-Nenow, P. Z.; Mertens, P. P. C.; Batten, C.; Gubbins, S.; Darpel, K. E.; Carpenter, S.
10.1101/2021.08.09.455771 — microbiology — Posted on 2021-08-11
2607 Quality-preserving low-cost probabilistic 3D denoising with applications to Computed Tomography
Horenko, I.; Pospisil, L.; Vecci, E.; Albrecht, S.; Gerber, A.; Rehbock, B.; Stroh, A.; Gerber, S.
10.1101/2021.08.10.455778 — bioinformatics — Posted on 2021-08-11
2609 A warmer growing season triggers earlier following spring phenology
Gu, H.; Qiao, Y.; Xi, Z.; Rossi, S.; G. Smith, N.; Liu, J.; Chen, L.
10.1101/2021.08.08.455549 — ecology — Posted on 2021-08-11
2611 In vitro culture of freshly isolated Trypanosoma brucei brucei bloodstream forms results in gene copy-number changes.
Mulindwa, J.; Ssentamu, G.; Matovu, E.; Marucha, K. K.; Aresta-Branco, F.; Helbig, C.; Clayton, C.
10.1101/2021.06.10.446608 — genomics — Posted on 2021-08-11
2612 One Health or Three? Transmission modelling of Klebsiella isolates reveals ecological barriers to transmission between humans, animals and the environment
Thorpe, H. A.; Booton, R.; Kallonen, T.; Gibbon, M. J.; Couto, N.; Passet, V. A.; Fernandez, J.; Rodrigues, C.; Matthews, L.; Mitchell, S.; Reeve, R.; David, S.; Merla, C.; Corbella, M.; Ferrari, C.; Comandatore, F.; Marone, P.; Brisse, S.; Sassera, D.; Corander, J.; Feil, E. J.
10.1101/2021.08.05.455249 — microbiology — Posted on 2021-08-11
2615 Transmit Field Bias Correction of T1w/T2w Myelin Maps
Glasser, M. F.; Coalson, T. S.; Harms, M. P.; Baum, G. L.; Autio, J. A.; Auerbach, E. A.; Xu, J.; Greve, D. N.; Yacoub, E.; Van Essen, D. C.; Bock, N. A.; Hayashi, T.
10.1101/2021.08.08.455570 — neuroscience — Posted on 2021-08-11
2621 Is the brain macroscopically linear? A system identification of resting state dynamics
Nozari, E.; Bertolero, M. A.; Stiso, J.; Caciagli, L.; Cornblath, E. J.; He, X.; Mahadevan, A. S.; Pappas, G. J.; Bassett, D. S.
10.1101/2020.12.21.423856 — neuroscience — Posted on 2021-08-11
2622 K+ efflux through postsynaptic NMDA receptors suppresses local astrocytic glutamate uptake
Tyurikova, O.; Shih, P.-Y.; Dembitskaya, Y.; Savtchenko, L. P.; McHugh, T.; Rusakov, D. A.; Semyanov, A.
10.1101/2020.11.07.372722 — neuroscience — Posted on 2021-08-11
2625 KChIP4a selectively controls mesolimbic dopamine neuron inhibitory integration and learning from negative prediction errors
Costa, K. M.; Hammer, N.; Knowlton, C. J.; Schwenk, J.; Mueller, T.; Schulte, D.; Fakler, B.; Canavier, C. C.; Roeper, J.
10.1101/344499 — neuroscience — Posted on 2021-08-11
2626 Structural modeling of the hERG potassium channel and associated drug interactions
Maly, J.; Emigh, A. M.; DeMarco, K. R.; Furutani, K.; Sack, J. T.; Clancy, C. E.; Vorobyov, I.; Yarov-Yarovoy, V.
10.1101/2021.07.08.451699 — biophysics — Posted on 2021-08-11
2630 A modelling framework for the prediction of the herd-level probability of infection from longitudinal data
Madouasse, A.; Mercat, M.; van Roon, A.; Graham, D.; Guelbenzu, M.; Santman Berends, I.; van Schaik, G.; Nielen, M.; Frössling, J.; Agren, E.; Humphry, R.; Eze, J.; Gunn, G.; Henry, M. K.; Gethmann, J.; More, S. J.; Toft, N.; Fourichon, C.
10.1101/2020.07.10.197426 — bioinformatics — Posted on 2021-08-11
2632 Powerful eQTL mapping through low coverage RNA sequencing
Schwarz, T.; Boltz, T.; Hou, K.; Bot, M.; Duan, C.; Olde Loohuis, L.; Boks, M. P.; Kahn, R. S.; Ophoff, R. A.; Pasaniuc, B.
10.1101/2021.08.08.455466 — genomics — Posted on 2021-08-11
2633 Multivariate Genomewide Association Analysis with IHT
Chu, B. B.; Ko, S.; Zhou, J. J.; Zhou, H.; Sinsheimer, J. S.; Lange, K. L.
10.1101/2021.08.04.455145 — genetics — Posted on 2021-08-11
2634 Deterministic shifts in molecular evolution correlate with convergence to annualism in killifishes
Thompson, A. W.; Black, A. C.; Huang, Y.; Shi, Q.; Furness, A. I.; Braasch, I.; Hoffmann, F. G.; Orti, G.
10.1101/2021.08.09.455723 — evolutionary biology — Posted on 2021-08-11
2635 Pre-Implantation Alcohol Exposure Induces Lasting Sex-Specific DNA Methylation Programming Errors in the Developing Forebrain
Legault, L.-M.; Doiron, K.; Breton-Larrivee, M.; Langford-Avelar, A.; Lemieux, A.; Caron, M.; Jerome-Majewska, L. A.; Sinnett, D.; McGraw, S.
10.1101/2020.12.07.415208 — developmental biology — Posted on 2021-08-11
2637 Known mechanisms account for less than half of antimicrobial resistance in a diverse collection of non-aureus staphylococci.
Felgate, H.; Crossman, L. C.; Gray, E.; Clifford, R.; Correia, A.; Dean, R.; Wain, J.; Langridge, G. C.
10.1101/2021.06.22.449369 — microbiology — Posted on 2021-08-11
2640 Efficacy of heat-killed and formalin-killed vaccines against Tilapia tilapinevirus in juvenile Nile tilapia (Oreochromis niloticus)
Mai, T. T.; Kayansamruaj, P.; Taengphu, S.; Senapin, S.; Costa, J. Z.; Pozo, J. d.; Thompson, K. D.; Rodkhum, C.; Dong, H. T.
10.1101/2021.06.03.447010 — immunology — Posted on 2021-08-11
2641 Mapping the human praxis network: an investigation of white matter disconnection in apraxia
Rosenzopf, H.; Wiesen, D.; Basilakos, A.; Yourganov, G.; Bonilha, L.; Rorden, C.; Fridriksson, J.; Karnath, H.-O.; Sperber, C.
10.1101/2020.04.14.041442 — neuroscience — Posted on 2021-08-11
2642 A Paradigm Change in Functional Brain Mapping: Suppressing the Thermal Noise in fMRI
Vizioli, L.; Moeller, S.; Dowdle, L.; Akcakaya, M.; De Martino, F.; Yacoub, E.; Ugurbil, K.
10.1101/2020.11.04.368357 — neuroscience — Posted on 2021-08-11
2644 A small molecule antagonizes jasmonic acid perception and auxin responses in vascular and nonvascular plants
Chini, A.; Monte, I.; Fernandez-Barbero, G.; Boter, M.; Hicks, G.; Raikhel, N. V.; Solano, R.
10.1101/2021.02.02.429350 — plant biology — Posted on 2021-08-11
2646 Extracellular Matrix Hydrogels Promote Expression of Muscle-Tendon Junction Proteins
Gaffney, L. S.; Davis, Z. G.; Mora-Navarro, C.; Fisher, M. B.; Freytes, D. O.
10.1101/2021.03.24.436805 — bioengineering — Posted on 2021-08-11
2651 Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics
Tsai, K.; Stojkovic, V.; Lee, D. J.; Young, I. D.; Szal, T.; Vazquez-Laslop, N.; Mankin, A. S.; Fraser, J. S.; Galonic Fujimori, D.
10.1101/2021.08.10.455846 — biophysics — Posted on 2021-08-10
2655 Lung injury induces alveolar type 2 cell hypertrophy and polyploidy with implications for repair and regeneration
Weng, A.; Maciel-Herrerias, M.; Watanabe, S. J.; Flozak, A. S.; Welch, L.; Aillon, R. P.; Grant, R.; Han, S.; Dada, L.; HInchcliff, M.; Misharin, A.; Budinger, G. S.; Gottardi, C. J.
10.1101/2021.08.10.455833 — cell biology — Posted on 2021-08-10
2657 RNA X-ray footprinting reveals the consequences of an in vivo acquired determinant of viral infectivity
Chandler-Bostock, R.; Bingham, R. J.; Clark, S.; Scott, A. J. P.; Wroblewski, E.; Barker, A.; White, S. J.; Dykeman, E. C.; Mata, C. P.; Bohon, J.; Farquhar, E.; Twarock, R.; Stockley, P. G.
10.1101/2021.08.10.455819 — molecular biology — Posted on 2021-08-10
2660 TSC2-extracellular matrix crosstalk controls pulmonary vascular proliferation and pulmonary hypertension
Shen, Y.; Goncharov, D. A.; Pena, A.; Baust, J.; Barragan, A. C.; Ray, A.; Rode, A.; Bachman, T. N.; Chang, B.; Rojas, M.; DeLisser, H.; Mora, A. L.; Kudryashova, T. V.; Goncharova, E. A.
10.1101/2021.08.10.455847 — molecular biology — Posted on 2021-08-10
2661 An ultrapotent neutralizing bispecific antibody with broad spectrum against SARS-CoV-2 variants
Zhang, H.; Huang, H.; Li, R.; Zhang, L.; Wang, Z.; Li, J.; Chen, J.; Su, H.; Zheng, D.; Su, Z.; Wang, L.; Deng, C.; Pei, s.; Zhu, S.; Li, C.; Yuan, Y.; Yue, H.; Wang, Y.; Li, X.; Liu, C.; Yu, J.; Zhang, H.; Li, S.; Huang, X.
10.1101/2021.08.10.455627 — microbiology — Posted on 2021-08-10
2662 Dysregulation of Hepatitis B Virus Nucleocapsid Assembly with RNA-directed Small Ligands
Patel, N.; Abulwerdi, F.; Fatehi, F.; Manfield, I.; Le Grice, S.; Schneekloth, J. S.; Twarock, R.; Stockley, P. G.
10.1101/2021.08.10.455820 — microbiology — Posted on 2021-08-10
2664 Repair of Noise-Induced Damage to Stereocilia F-actin Cores is Facilitated by XIRP2
Wagner, E. L.; Im, J.-S.; Nakahata, M. I.; Imbery, T. E.; Li, S.; Chen, D. B.; Noy, Y.; Archer, D. W.; Xu, W.; Hashisaki, G. T.; Avraham, K. B.; Shin, J.-B.
10.1101/2021.08.10.455815 — neuroscience — Posted on 2021-08-10
2665 EEG spectral exponent as a synthetic index for the longitudinal assessment of stroke recovery.
Lanzone, J.; Colombo, M.; Sarasso, S.; Zappasodi, F.; Rosanova, M.; Massimini, M.; Di Lazzaro, V.; Assenza, G.
10.1101/2021.08.09.455664 — neuroscience — Posted on 2021-08-10
2669 Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans
Oliva, A.; Issa, K.; Abi Hachem, R.; Jang, D.; Gupta, R.; Moseman, E. A.; Matsunami, H.; Goldstein, B. J.
10.1101/2021.08.09.455538 — neuroscience — Posted on 2021-08-10
2670 Upregulation of C4 characteristics does not consistently improve photosynthetic performance in intraspecific hybrids of a grass
Bianconi, M. E.; Sotelo, G.; Curran, E. V.; Milenkovic, V.; Samaritani, E.; Dunning, L. T.; Osborne, C. P.; Christin, P.-A.
10.1101/2021.08.10.455822 — plant biology — Posted on 2021-08-10
2672 GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma
de Andres, M. P.; Jackson, R.; Pilarsky, C.; Schlitter, A. M.; Costello, E.; Greenhalf, W.; Ganeh, P.; Knoesel, T.; Palmer, D.; Ruemmele, P.; Weichert, W.; Buechler, M.; Hackert, T.; Neoptolemos, J. P.; Malats, N.; Martinelli, P.; Real, F. X.
10.1101/2021.08.09.455642 — cancer biology — Posted on 2021-08-10
2673 Polysorbate 80 Controls Morphology, Structure and Stability of Human Insulin Amyloid-Like Spherulites
Zhou, X.; Galparsoro, D. F.; Madsen, A. O.; Vetri, V.; van de Weert, M.; Nielsen, H. M.; Fodera, V.
10.1101/2021.08.10.455855 — biophysics — Posted on 2021-08-10
2675 Infectious SARS-CoV-2 is emitted in aerosols
Hawks, S. A.; Prussin, A. J.; Kuchinsky, S. C.; Pan, J.; Marr, L. C.; Duggal, N. K.
10.1101/2021.08.10.455702 — microbiology — Posted on 2021-08-10
2676 A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
Martinez-Valbuena, I.; Visanji, N. P.; Kim, A.; Lau, H. H. C.; So, R. W. L.; Alshimemeri, S.; Gao, A.; Seidman, M.; Luquin, M. R.; Watts, J. C.; Lang, A. E.; Kovacs, G. G.
10.1101/2021.08.10.455800 — neuroscience — Posted on 2021-08-10
2677 Rationalizing generation of broad spectrum antibiotics with the addition of a primary amine
Haloi, N.; Vasan, A. K.; Geddes, E. J.; Prasanna, A.; Wen, P.-C.; Metcalf, W. W.; Hergenrother, P. J.; Tajkhorshid, E.
10.1101/2021.08.10.455597 — biophysics — Posted on 2021-08-10
2678 Cleavage of histone H2A during embryonic stem cell differentiation destabilizes nucleosomes to counteract gene activation
Coradin, M.; Cesare, J.; Lan, Y.; Zhu, Z.; Lund, P. J.; Sidoli, S.; Kori, Y.; Lu, C.; Porter, E. G.; Robert, C. W. M.; Garcia, B. A.
10.1101/2021.08.10.455684 — developmental biology — Posted on 2021-08-10
2679 Characterization of the composition and functioning of the Crumbs complex in C. elegans
Castiglioni, V. G.; Ramalho, J. J.; Kroll, J. R.; Stucchi, R.; van Beuzekom, H.; Schmidt, R.; Altelaar, M.; Boxem, M.
10.1101/2021.08.10.455623 — developmental biology — Posted on 2021-08-10
2681 Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
Peterka, M.; Akrap, N.; Li, S.; Wimberger, S.; Hsieh, P.-P.; Degtev, D.; Bestas, B.; Barr, J.; van de Plassche, S.; Mendoza-Garcia, P.; Svikovic, S.; Sienski, G.; Firth, M.; Maresca, M.
10.1101/2021.08.10.455572 — molecular biology — Posted on 2021-08-10
2683 Mucin induces CRISPR-Cas defence in an opportunistic pathogen
Almeida, G. M.; Hoikkala, V.; Ravantti, J. J.; Rantanen, N.; Sundberg, L.-R.
10.1101/2021.08.10.455787 — microbiology — Posted on 2021-08-10
2684 Reservoir host studies of Lloviu virus: first isolation, sequencing and serology in Schreiber's bats in Europe
Kemenesi, G.; Toth, G. E.; Mayora-Neto, M.; Scott, S.; Temperton, N.; Wright, E.; Muhlberger, E.; Hume, A. J.; Zana, B.; Boldogh, S. A.; Gorfol, T.; Estok, P.; Lanszki, Z.; Somogyi, B. A.; Nagy, A.; Pereszlenyi, C. I.; Dudas, G.; Foldes, F.; Kurucz, K.; Madai, M.; Zeghbib, S.; Maes, P.; Vanmechelen, B.; Jakab, F.
10.1101/2021.08.10.455806 — microbiology — Posted on 2021-08-10
2686 Age and sex dependent variability of type 2 dopamine receptors in the human brain: A large-scale PET cohort
Malen, T.; Karjalainen, T.; Isojärvi, J.; Vehtari, A.; Bürkner, P.-C.; Putkinen, V.; Kaasinen, V.; Hietala, J.; Nuutila, P.; Rinne, J.; Nummenmaa, L.
10.1101/2021.08.10.455776 — neuroscience — Posted on 2021-08-10
2687 Vision is Required for Cell Type Specification in the Visual Cortex
Cheng, S.; Butrus, S.; Xu, V.; Sagireddy, S.; Tan, L.; Shekhar, K.; Zipursky, S. L.
10.1101/2021.08.10.455824 — neuroscience — Posted on 2021-08-10
2688 Multiomics reveals the genomic, proteomic and metabolic influences of histidyl dipeptides on heart
Baba, S.; Yan, K.; Mei, Z.; Zhao, J.; Prodhan, M. A.; Obal, D.; Katragadda, K.; Doelling, B.; Hoetker, D.; Posa, D. K.; He, L.; Yin, X.; Shah, J.; Pan, J.; Rai, S.; Lorkiewicz, P. K.; Zhang, X.; Li, S.; Bhatnagar, A.
10.1101/2021.08.10.455864 — systems biology — Posted on 2021-08-10
2690 Laterally transferred macrophage mitochondria acts as a signaling source promoting cancer cell proliferation
Kidwell, C. U.; Casalini, J. R.; Pradeep, S.; Scherer, S. D.; Greiner, D.; Johnson, J. S.; Olson, G. S.; Rutter, J.; Welm, A. L.; Zangle, T. A.; Roh-Johnson, M.
10.1101/2021.08.10.455713 — cancer biology — Posted on 2021-08-10
2691 MYCN mediates cysteine addiction and sensitizes to ferroptosis
Alborzinia, H.; Florez, A. F.; Gogolin, S.; Brueckner, L. M.; Shao, C.; Gartlgruber, M.; Nadler Holly, M.; Ziehm, M.; Paul, F.; Steinhauser, S.; Bell, E.; Shaikhkarami, M.; Hartlieb, S.; Dreidax, D.; Hess, E. M.; Kreth, J.; Poschet, G.; Buettner, M.; Nicke, B.; Stresemann, C.; Reiling, J. H.; Fischer, M.; Amit, I.; Selbach, M.; Herrmann, C.; Woelfl, S.; Henrich, K. O.; Hoefer, T.; Westermann, F.
10.1101/2021.08.10.455675 — cancer biology — Posted on 2021-08-10
2695 geneBasis: an iterative approach for unsupervised selection of targeted gene panels from scRNA-seq.
Missarova, A.; Jain, J.; Butler, A.; Ghazanfar, S.; Stuart, T.; Brusko, M.; Wasserfall, C.; Nick, H.; Brusko, T.; Atkinson, M.; Satija, R.; Marioni, J.
10.1101/2021.08.10.455720 — bioinformatics — Posted on 2021-08-10
2697 pOPIN-GG: A resource for modular assembly in protein expression vectors
Bentham, A. R.; Youles, M.; Mendel, M. N.; Varden, F. A.; De la Concepcion, J. C.; Banfield, M. J.
10.1101/2021.08.10.455798 — biochemistry — Posted on 2021-08-10
2698 Echolocating whales use ultra-fast echo-kinetic responses to track evasive prey.
Vance, H. M.; Madsen, P. T.; Aguilar de Soto, N.; Wisniewska, D. M.; Ladegaard, M.; Hooker, S. K.; Johnson, M.
10.1101/2021.08.10.455788 — animal behavior and cognition — Posted on 2021-08-10
2699 Single-molecule simultaneous profiling of DNA methylation and DNA-protein interactions with Nanopore-DamID
Cheetham, S. W.; Jafrani, Y. M. A.; Andersen, S. B.; Jansz, N.; Ewing, A. D.; Faulkner, G. J.
10.1101/2021.08.09.455753 — genomics — Posted on 2021-08-10
2702 Mammal virus diversity estimates are unstable due to accelerating discovery effort
Gibb, R.; Albery, G. F.; Mollentze, N. F.; Eskew, E. A.; Brierley, L.; Ryan, S. J.; Seifert, S. N.; Carlson, C. J.
10.1101/2021.08.10.455791 — ecology — Posted on 2021-08-10
2704 Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and Atherosclerosis
Williams, D.; Mahmoud, M.; Liu, R.; Andueza, A.; Kumar, S.; Kang, D.-W.; Zhang, J.; Tamargo, I.; Villa-Roel, N.; Baek, K.-I.; Lee, H.; An, Y.; Zhang, L.; Tate, E. W.; Bagchi, P.; Pohl, J.; Mosnier, L.; Diamandis, E. P.; Mihara, K.; Hollenberg, M.; Dai, Z.; Jo, H.
10.1101/2021.08.10.455857 — cell biology — Posted on 2021-08-10
2705 Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson's disease-specific hepatocytes
Song, D.; Takahashi, G.; Zheng, Y.-W.; Matsuo-Takasaki, M.; Li, J.; Takami, M.; An, Y.; Hemmi, Y.; Miharada, N.; Fujioka, T.; Noguchi, M.; Nakajima, T.; Saito, m. K.; Nakamura, Y.; Oda, T.; MIyaoka, Y.; Hayashi, Y.
10.1101/2021.08.10.455792 — cell biology — Posted on 2021-08-10
2706 Arap1 Loss Causes RPE Phagocytic Dysfunction and Subsequent Photoreceptor Death
Shao, A.; Jacobo Lopez, A.; Chen, J.; Tham, A.; Javier, S.; Quiroz, A.; Frick, S.; Levine, E. M.; Lloyd, K. C. K.; Leonard, B. C.; Murphy, C. J.; Glaser, T. M.; Moshiri, A.
10.1101/2021.08.09.455745 — molecular biology — Posted on 2021-08-10
2707 ACE2 Pathway Regulates Thermogenesis and Energy Metabolism
Cao, X.; Shi, T.; Zhang, C.; Jin, W.; Song, L.; Zhang, Y.; Liu, J.; Yang, F.; Rotimi, C. N.; Xu, A.; Yang, J.
10.1101/2021.08.10.455823 — molecular biology — Posted on 2021-08-10
2708 Whole-brain connectivity during encoding: age-related differences and associations with cognitive and brain structural decline
Capogna, E.; Sneve, M. H.; Raud, L.; Folvik, L.; Ness, H.; Walhovd, K. B.; Fjell, A. M.; Vidal-Pineiro, D.
10.1101/2021.08.10.455779 — neuroscience — Posted on 2021-08-10
2711 Trial by trial, machine learning approach identifies temporally discrete Aδ- and C-fibre mediated laser evoked potentials that predict pain behaviour in rats.
Sales, A. C.; Blockeel, A. J.; Huxter, J. R.; Dunham, J. P.; Drake, R. A.; Truini, A.; Mouraux, A.; Treede, R.-D.; Phillips, K. G.; Pickering, A. E.
10.1101/2021.08.10.455801 — neuroscience — Posted on 2021-08-10
2713 Engineering site-selective incorporation of fluorine into natural product analogs
Sirirungruang, S.; Ad, O.; Privalsky, T. M.; Ramesh, S.; Sax, J. L.; Dong, H.; Baidoo, E. E.; Amer, B.; Khosla, C.; Chang, M. C.
10.1101/2021.08.09.455754 — synthetic biology — Posted on 2021-08-10
2714 Dose-dependent dissociation of pro-cognitive effects of donepezil on attention and cognitive flexibility in rhesus monkeys
Hassani, S. A.; Lendor, S.; Neumann, A.; Roy, K. S.; Banaie Boroujeni, K.; Hoffman, K. L.; Pawliszyn, J.; Womelsdorf, T.
10.1101/2021.08.09.455743 — pharmacology and toxicology — Posted on 2021-08-10
2716 H3-K27M-Mutant Nucleosomes Interact with MLL1 to Shape the Glioma Epigenetic Landscape
Furth, N.; Algranati, D.; Dassa, B.; Beresh, O.; Fedyuk, V.; Morris, N.; Kasper, L.; Jones, D.; Monje, M.; Baker, S.; Shema, E.
10.1101/2021.08.09.455680 — cancer biology — Posted on 2021-08-10
2723 Antibodies control metabolism by regulating insulin homeostasis
Amendt, T.; Allies, G.; Nicolo, A.; El Ayoubi, O.; Young, M.; Roeszer, T.; Setz, C. S.; Warnatz, K.; Jumaa, H.
10.1101/2021.08.10.455644 — immunology — Posted on 2021-08-10
2727 Neuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLC
Qu, F.; Cao, S.; Michno, W.; Madubata, C. J.; Puno, A.; Drainas, A. P.; Lee, M. C.; Yang, D.; Toland, A.; Kong, C.; Das, M.; Winslow, M. M.; Pasca, A. M.; Sage, J.
10.1101/2021.08.10.455426 — cancer biology — Posted on 2021-08-10
2732 Neutrophil-epithelial interactions augment infectivity and pro-inflammatory responses to SARS-CoV-2 infection
Calvert, B. A.; Quiroz, E. J.; Lorenzana, Z.; Doan, N.; Kim, S.; Senger, C. N.; Wallace, W. D.; Salomon, M.; Henley, J.; Ryan, A. L.
10.1101/2021.08.09.455472 — cell biology — Posted on 2021-08-10
2734 A two-stage approach for the spatio-temporal analysis of high-throughput phenotyping data
Pérez-Valencia, D. M.; Rodríguez-Álvarez, M. X.; Boer, M. P.; Kronenberg, L.; Hund, A.; Cabrera-Bosquet, L.; Millet, E. J.; van Eeuwijk, F. A.
10.1101/2021.08.10.455613 — genetics — Posted on 2021-08-10
2738 PRC1 Sustains the Memory of Neuronal Fate Independent of PRC2 Function
Dasen, J.; Sawai, A.; Pfennig, S.; Bulajic, M.; Miller, A.; Khodadadi-Jamayran, A.; Mazzoni, E. O.
10.1101/2021.08.09.455667 — neuroscience — Posted on 2021-08-10
2740 Karyotype asymmetry in Cuscuta L. subgenus Pachystigma reflects its repeat DNA composition
Ibiapino, A.; Baez, M.; Garcia, M. A.; Costea, M.; Stefanovic, S.; Pedrosa-Harand, A.
10.1101/2021.08.09.455742 — plant biology — Posted on 2021-08-10
2741 An Association Test of the Spatial Distribution of Rare Missense Variants within Protein Structures Improves Statistical Power of Sequencing Studies
Jin, B.; Capra, J. A.; Benchek, P.; Wheeler, N. R.; Naj, A. C.; Hamilton-Nelson, K. L.; Farrell, J. J.; Leung, Y. Y.; Kunkle, B. W.; Vardarajan, B. N.; Schellenberg, G. D.; Mayeux, R.; Wang, L.-S.; Farrer, L. A.; Pericak-Vance, M.; Martin, E. R.; Haines, J. L.; Crawford, D. C.; Bush, W. S.
10.1101/2021.08.09.455695 — bioinformatics — Posted on 2021-08-10
2744 Genetic diversity of wild and cultivated Coffea canephora in northeastern DR Congo and the implications for conservation.
Abeele, S. V.; Janssens, S. B.; Anio, J. A.; Bawin, Y.; Depecker, J.; Kambale, B.; Mwanga, I. M.; Ebele, T.; Ntore, S.; Stoffelen, P.; Vandelook, F.
10.1101/2021.08.09.455630 — genetics — Posted on 2021-08-10
2745 Prevalence of heterotrophic methylmercury detoxifying bacteria across oceanic regions
Sanz-Saez, I.; Pereira Garcia, C.; Bravo, A. G.; Trujillo, L.; Pla i Ferriol, M.; Capilla, M.; Sanchez, P.; Rodriguez Martin-Doimeadios, R. d. C.; Acinas, S. G.; Sanchez, O.
10.1101/2021.08.09.455674 — microbiology — Posted on 2021-08-10
2746 Quantitative Restoration of Immune Defense in Old Animals Determined by Naive Antigen-Specific CD8 T cell Numbers
Uhrlaub, J.; Jergovic, M.; Bradshaw, C. M.; Sonar, S.; Coplen, C. P.; Dudakov, J.; Murray, K. O.; Lanteri, M. C.; Busch, M. P.; van den Brink, M. R. M.; Nikolich-Zugich, J.
10.1101/2021.08.09.453882 — immunology — Posted on 2021-08-10
2747 TNFa and IL-6 promote ex-vivo proliferation of lineage-committed human regulatory T cells
Skartsis, N.; Peng, Y.; Ferreira, L. M. R.; Nguyen, V.; Muller, Y.; Vincenti, F.; Tang, Q.
10.1101/2021.08.09.455690 — immunology — Posted on 2021-08-10
2750 Immediate Impact of Yogic Breathing on Pulsatile Cerebrospinal Fluid Dynamics
Yildiz, S.; Grinstead, J.; Hildebrand, A.; Oshinski, J.; Rooney, W. D.; Lim, M. M.; Oken, B.
10.1101/2021.08.09.455068 — neuroscience — Posted on 2021-08-10
2751 Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia
Ferreira, C. B.; Silva, T. M.; Silva, P. E.; Czeisler, C.; Otero, J. J.; Takakura, A. C.; Moreira, T. S.
10.1101/2021.08.09.455641 — neuroscience — Posted on 2021-08-10
2752 Inhibiting retinoic acid mitigates vision loss in a mouse model of retinal degeneration
Telias, M.; Sit, K.; Frozenfar, D.; Smith, B.; Misra, A.; Goard, M. J.; Kramer, R. H.
10.1101/2021.08.09.455683 — neuroscience — Posted on 2021-08-10
2754 Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics
Bhatia, S.; Kramer, M.; Russo, S.; Naik, P.; Arun, G.; Brophy, K.; Andrews, P. A.; Fan, C.; Perou, C. M.; Preall, J.; Ha, T.; Rishi, A.; Wilkinson, J. E.; McCombie, W. R.; Kostroff, K.; Spector, D. L.
10.1101/2021.08.09.455691 — cancer biology — Posted on 2021-08-10
2755 Phased Mutations and Complex Rearrangements in Human Prostate Cancer Cell Lines through Linked-Read Whole Genome Sequencing
Pham, M.-T. N.; Gupta, H.; Gupta, A.; Vaghasia, A.; Skaist, A.; Garrison, M. A.; Coulter, J. B.; Haffner, M. C.; Wheelan, S. J.; Isaacs, W.; Nelson, W.; Yegnasubramanian, S.
10.1101/2021.08.09.455584 — cancer biology — Posted on 2021-08-10
2757 Immune Cell Profiling Reveals MAIT and Effector Memory CD4+ T Cell Recovery Link to Control of Cytomegalovirus Reactivation after Stem Cell Transplant
Stern, L.; McGuire, H. M.; Avdic, S.; Fazekas de St Groth, B. F.; Gottlieb, D.; Abendroth, A.; Blyth, E.; Slobedman, B.
10.1101/2021.08.09.455593 — immunology — Posted on 2021-08-10
2759 Atmospheric particulate matter aggravates CNS demyelination via TLR-4/NF-κB-mediated microglia pathogenic activities
Han, B.; Li, X.; Deng, S.-Y.; Ye, Z.-Q.; Ai, R.-S.; Deng, X.; Ma, W.; Xiao, S.; Wang, J.-Z.; Wang, L.-M.; Xie, C.; Zhang, Y.; Xu, Y.; Zhang, Y.
10.1101/2021.08.09.455666 — neuroscience — Posted on 2021-08-10
2760 The Normative Modeling Framework for Computational Psychiatry
Rutherford, S.; Kia, S. M.; Wolfers, T.; Fraza, C.; Zabihi, M.; Dinga, R.; Berthet, P.; Worker, A.; Verdi, S.; Ruhe, H. G.; Beckmann, C. F.; Marquand, A. F.
10.1101/2021.08.08.455583 — neuroscience — Posted on 2021-08-10
2763 Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model
Wang, G.; Wang, Y.; Li, J.; Peng, R.; Liang, X.; Chen, X.; Jiang, G.; Shi, J.; Si-ma, Y.; Xu, S.
10.1101/2021.08.09.455622 — pharmacology and toxicology — Posted on 2021-08-10
2764 Bisphosphonate drugs have actions outside the skeleton and inhibit the mevalonate pathway in alveolar macrophages
Rogers, M. J.; Munoz, M. A.; Fletcher, E. K.; Skinner, O. P.; Jurczyluk, J.; Kristianto, E.; Hodson, M.; Sun, S.; Ebetino, F. H.; Croucher, D. R.; Hansbro, P. M.; Center, J. R.
10.1101/2021.08.09.455652 — pharmacology and toxicology — Posted on 2021-08-10
2765 Benchmarking artificial intelligence methods for end-to-end computational pathology
Laleh, N. G.; Muti, H. S.; Loeffler, C. M. L.; Echle, A.; Saldanha, O. L.; Mahmood, F.; Lu, M. Y.; Trautwein, C.; Langer, R.; Dislich, B.; Buelow, R. D.; Grabsch, H. I.; Brenner, H.; Chang-Claude, J.; Alwers, E.; Brinker, T. J.; Khader, F.; Truhn, D.; Gaisa, N. T.; Boor, P.; Hoffmeister, M.; Schulz, V.; Kather, J. N.
10.1101/2021.08.09.455633 — bioinformatics — Posted on 2021-08-10
2766 Evaluating the impact of in silico predictors on clinical variant classification
Wilcox, E.; Sarmady, M.; Wulf, B.; Wright, M.; Rehm, H.; Biesecker, L. G.; Abou Tayoun, A.
10.1101/2021.08.09.455612 — genomics — Posted on 2021-08-10
2767 The emergence of highly fit SARS-CoV-2 variants accelerated by recombination
Garvin, M. R.; Prates, E. T.; Romero, J.; Cliff, A.; Gazolla, J. G. F. M.; Pickholz, M.; Pavicic, M.; Jacobson, D.
10.1101/2021.08.03.454981 — evolutionary biology — Posted on 2021-08-10
2768 The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth
Boezio, G. L.; Gollin, J.; Zhao, S.; Priya, R.; Mansingh, S.; Guenther, S.; Fukuda, N.; Gunawan, F.; Stainier, D. Y. R.
10.1101/2021.08.09.455639 — developmental biology — Posted on 2021-08-10
2770 Drug repurposing based on a Quantum-Inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2 including vitamin B12
Jimenez-Guardeno, J. M.; Ortega-Prieto, A. M.; Menendez Moreno, B.; Maguire, T. J. A.; Richardson, A.; Diaz Hernandez, J. I.; Diez Perez, J.; Zuckerman, M.; Mercadal Playa, A.; Cordero Deline, C.; Malim, M. H.; Martinez-Nunez, R. T.
10.1101/2021.06.25.449609 — microbiology — Posted on 2021-08-10
2771 Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524)
Lo, M. K.; Shrivastava-Ranjan, P.; Chatterjee, P.; Flint, M.; Beadle, J. R.; Valiaeva, N.; Schooley, R.; Hostetler, K. Y.; Montgomery, J.; Spiropoulou, C. F.
10.1101/2021.08.06.455494 — pharmacology and toxicology — Posted on 2021-08-10
2772 Condensation of the influenza viral fusion peptide alters membrane structure and water permeability
Haldar, S.; Rice, A.; Wang, E.; Blank, P. S.; Akimov, S. A.; Galimzyanov, T. R.; Pastor, R. W.; Zimmerberg, J.
10.1101/2021.08.09.455689 — biophysics — Posted on 2021-08-10
2777 Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafish
Baranasic, D.; Hoertenhuber, M.; Balwierz, P.; Zehnder, T.; Mukarram, A. K.; Nepal, C.; Varnai, C.; Hadzhiev, Y.; Jimenez-Gonzalez, A.; Li, N.; Wragg, J. W.; D'Orazio, F.; Diaz, N.; Hernandez-Rodriguez, B.; Chen, Z.; Stoiber, M.; Dong, M.; Stevens, I.; Ross, S. E.; Eagle, A.; Martin, R.; Obasaju, P.; Rastegar, S.; McGarvey, A. C.; Kopp, W.; Chambers, E.; Wang, D.; Kim, H. K.; Acemel, R. D.; Naranjo, S.; Lapinski, M.; Chong-Morrison, V.; Mathavan, S.; Peers, B.; Sauka-Spengler, T.; Vingron, M.; Carninci, P.; Ohler, U.; Lacadie, S. A.; Burgess, S.; Winata, C.; van Eeden, F.; Vaquerizas, J. M.; G
10.1101/2021.08.09.454869 — developmental biology — Posted on 2021-08-10
2778 Deterministic shifts in molecular evolution correlate with convergence to annualism in killifishes
Thompson, A. W.; Black, A. C.; Huang, Y.; Shi, Q.; Furness, A. I.; Braasch, I.; Hoffmann, F. G.; Orti, G.
10.1101/2021.08.09.455723 — evolutionary biology — Posted on 2021-08-10
2780 The quasi-universality of nestedness in the structure of quantitative plant-parasite interactions
Moury, B.; Audergon, J.-M.; Baudracco-Arnas, S.; BEN KRIMA, S.; Bertrand, F.; Boissot, N.; Buisson, M.; Caffier, V.; Cantet, M.; Chaneac, S.; Constant, C.; Delmotte, F.; Dogimont, C.; Doumayrou, J.; Fabre, F.; Fournet, S.; Grimault, V.; Jaunet, T.; Justafre, I.; Lefebvre, V.; Losdat, D.; MARCEL, T. C.; Montarry, J.; Morris, C. E.; Omrani, M.; Paineau, M.; Perrot, S.; Pilet-Nayel, M.-L.; Ruellan, Y.
10.1101/2021.03.03.433745 — pathology — Posted on 2021-08-10
2783 LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants
Alasiri, A.; Karczewski, K. J.; Cole, B.; Loza, B.-L.; Moore, J. H.; van der Laan, S. W.; Asselbergs, F. W.; Keating, B. J.; van Setten, J.
10.1101/2021.08.09.455694 — bioinformatics — Posted on 2021-08-10
2785 Representing the sediment retention ecosystem service within an ecosystem account of the Mitchell catchment
McMahon, J. M.; Hasan, S.; Brooks, A.; Curwen, G.; Dyke, J.; Saint Ange, C.; Smart, J. C. R.
10.1101/2021.08.06.455476 — ecology — Posted on 2021-08-10
2788 A high content microscopy screening identifies new genes involved in cell width control in Bacillus subtilis
Juillot, D.; Cornilleau, C.; Deboosere, N.; Billaudeau, C.; Evouna-Mengue, P.; Lejard, V.; Brodin, P.; Carballido-Lopez, R.; Chastanet, A.
10.1101/2021.06.10.444761 — microbiology — Posted on 2021-08-10
2794 Rapid screening methods of potato cultivars for low glycemic traits
Rivas, R.; Dratz, E.; Wagner, T.; Secor, G.; Leckband, A. D.; Sands, D.
10.1101/2021.08.09.455724 — plant biology — Posted on 2021-08-09
2796 In vivo study on the healing of bone defect treated with non-thermal atmospheric pressure gas discharge plasma
Shimatani, A.; Toyoda, H.; Orita, K.; Hirakawa, Y.; Aoki, K.; Oh, J.-S.; Shirafuji, T.; Nakamura, H.
10.1101/2021.08.09.455731 — pathology — Posted on 2021-08-09
2798 Genetic diversity of local and introduced cassava germplasm in Burundi using DArTseq molecular analyses
pierre, n.; Wamalwa, L. N.; Muiru, W. M.; Simon, B.; Kanju, E.; Ferguson, M. E.; Ndavi, M. M.; Tumwegamire, S.
10.1101/2021.08.09.455732 — genetics — Posted on 2021-08-09
2799 Complex feline disease mapping using a dense genotyping array
Hernandez, I.; Hayward, J. J.; Brockman, J.; White, M.; Mouttham, L.; Wilcox, E.; Garrison, S.; Castelhano, M.; Loftus, J.; Gomes, F. E.; Balkman, C.; Brooks, M.; Fiani, N.; Forman, M.; Kern, T.; Kornreich, B.; Ledbetter, E.; Peralta, S.; Struble, A.; Caligiuri, L.; Corey, E.; Lin, L.; Jordan, J.; Sack, D.; Boyko, A.; Lyons, L.; Todhunter, R.
10.1101/2021.08.09.455727 — genetics — Posted on 2021-08-09
2801 A new approach to integrate phylogenetic structure and partner availability to study biotic specialization in ecological networks
Pardo-De la Hoz, C. J.; Medeiros, I. D.; Gibert, J. P.; Chagnon, P.-L.; Magain, N.; Miadlikowska, J.; Lutzoni, F.
10.1101/2021.08.04.454912 — ecology — Posted on 2021-08-09
2804 Functional connectomics spanning multiple areas of mouse visual cortex
MICrONs Consortium, ; Bae, J. A.; Baptiste, M.; Bodor, A. L.; Brittain, D.; Buchanan, J.; Bumbarger, D. J.; Castro, M. A.; Celii, B.; Cobos, E.; Collman, F.; da Costa, N. M.; Dorkenwald, S.; Elabbady, L.; Fahey, P. G.; Fliss, T.; Froudarakis, E.; Gager, J.; Gamlin, C.; Halageri, A.; Hebditch, J.; Jia, Z.; Jordan, C.; Kapner, D.; Kemnitz, N.; Kinn, S.; Koolman, S.; Kuehner, K.; Lee, K.; Li, K.; Lu, R.; Macrina, T.; Mahalingam, G.; McReynolds, S.; Miranda, E.; Mitchell, E.; Mondal, S. S.; Moore, M.; Mu, S.; Muhammad, T.; Nehoran, B.; Ogedengbe, O.; Papadopoulos, C.; Papadopoulos, S.; Patel, S.;
10.1101/2021.07.28.454025 — neuroscience — Posted on 2021-08-09
2805 Charting Brain Growth and Aging at High Spatial Precision
Rutherford, S.; Fraza, C.; Dinga, R.; Kia, S. M.; Wolfers, T.; Zabihi, M.; Berthet, P.; Worker, A.; Verdi, S.; Andrews, D.; Han, L.; Bayer, J.; Dazzan, P.; McGuire, P.; Mocking, R. T.; Schene, A.; Sripada, C.; Tso, I. F.; Duval, E. R.; Chang, S.-E.; Pennix, B. W.; Heitzeg, M. M.; Burt, S. A.; Hyde, L.; Amaral, D.; Nordahl, C. W.; Andreasssen, O. A.; Westlye, L. T.; Zahn, R.; Ruhe, H. G.; Beckmann, C.; Marquand, A. F.
10.1101/2021.08.08.455487 — neuroscience — Posted on 2021-08-09
2810 Synergy of chemotherapy and macrophage depletion leads to B cell-mediated T cell memory activation and durable triple negative breast cancer regression
Singh, S.; Lee, N.; Bado, I.; Hamor, C.; Zhang, L.; Aguirre, S.; Hu, J.; Shen, Y.; Xu, Y.; Gao, Y.; Pedroza, D.; Zhan, N.; Chen, S.-H.; Wan, Y.-W.; Liu, Z.; Chang, J.; Hollern, D.; Perou, C.; Zhang, X.; Rosen, J. M.
10.1101/2021.02.22.432300 — cancer biology — Posted on 2021-08-09
2811 OTUs clustering should be avoided for defining oral microbiome
Regueira-Iglesias, A.; Vazquez-Gonzalez, L.; Balsa-Castro, C.; Blanco-Pintos, T.; Arce, V. M.; Carreira, M. J.; Tomas, I.
10.1101/2021.08.09.455616 — bioinformatics — Posted on 2021-08-09
2813 Multi-scale semi-supervised clustering of brain images: deriving disease subtypes
WEN, J.; Varol, E.; Sotiras, A.; Yang, Z.; Chand, G. B.; Erus, G.; Shou, H.; Hwang, G.; Davatzikos, C.
10.1101/2021.04.19.440501 — bioinformatics — Posted on 2021-08-09
2814 ORT: A workflow linking genome-scale metabolic models with reactive transport codes
Rubinstein, R. L.; Borton, M. A.; Zhou, H.; Shaffer, M.; Hoyt, D. W.; Stegen, J.; Henry, C. S.; Wrighton, K. C.; Versteeg, R.
10.1101/2021.03.02.433463 — bioinformatics — Posted on 2021-08-09
2815 Beyond single discrete responses: An integrative and multidimensional analysis of behavioral dynamics assisted by Machine Learning
Leon, A.; Hernandez, V.; Lopez, J.; Guzman, I.; Quintero, V.; Toledo, P.; Avendano-Garrido, M. L.; Hernandez-Linares, C.; Escamilla, E.
10.1101/2021.03.17.435751 — animal behavior and cognition — Posted on 2021-08-09
2818 Segmenting biological specimens from photos to understand the evolution of UV plumage in passerine birds
He, Y.; Cooney, C. R.; Varley, Z. K.; Nouri, L. O.; Moody, C. J. A.; Jardine, M. D.; Maddock, S.; Thomas, G. H.
10.1101/2021.07.22.453339 — evolutionary biology — Posted on 2021-08-09
2819 The complex genetics of symbiotic extended phenotypes across environments in a model mutualism
Batstone, R. T.; Lindgren, H. K.; Allsup, C. M.; Goralka, L. A.; Riley, A. B.; Grillo, M. A.; Marshall-Colon, A.; Heath, K.
10.1101/2021.08.03.454976 — evolutionary biology — Posted on 2021-08-09
2822 Noncanonical Notch signals have opposing roles during cardiac development
Miyamoto, M.; Andersen, P.; Sulistio, E.; Liu, X.; Murphy, S.; Kannan, S.; Nam, L.; Miyamoto, W.; Tampakakis, E.; Hibino, N.; Uosaki, H.; Kwon, C.
10.1101/2021.08.09.455692 — developmental biology — Posted on 2021-08-09
2823 Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas
Borner, K.; Teichmann, S. A.; Quardokus, E. M.; Gee, J.; Browne, K.; Osumi-Sutherland, D.; Herr, B. W.; Bueckle, A.; Paul, H.; Haniffa, M. A.; Jardine, L.; Bernard, A.; Ding, S.-L.; Miller, J. A.; Lin, S.; Halushka, M.; Boppana, A.; Longacre, T. A.; Hickey, J.; Lin, Y.; Valerius, M. T.; He, Y.; Pryhuber, G.; Sun, X.; Jorgensen, M.; Radtke, A.; Wasserfall, C.; Ginty, F.; Ho, J.; Sunshine, J.; Beuschel, R. T.; Brusko, M.; Lee, S.; Malhotra, R.; Jain, S.; Weber, G.
10.1101/2021.05.31.446440 — cell biology — Posted on 2021-08-09
2824 Membrane cholesterol regulates TRPV4 function, cytoskeletal expression and the cellular response to tension
Lakk, M.; Hoffmann, G. E.; Gorusupudi, A.; Enyong, E.; Bernstein, P.; Toft-Bertelsen, T. L.; MacAulay, N.; Elliott, M. H.; Krizaj, D.
10.1101/2020.12.01.406850 — cell biology — Posted on 2021-08-09
2825 HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells
Reuschl, A.-K.; Shivkumar, M.; Mesner, D.; Pallett, L. J.; Guerra-Assuncao, J. A.; Madansein, R.; Dullabh, K. J.; Sigal, A.; Thornhill, J. P.; Herrera, C.; Fidler, S.; Noursadeghi, M.; Maini, M.; Jolly, C.
10.1101/2021.01.25.428084 — microbiology — Posted on 2021-08-09
2828 A Systematic Comparison of Differential Analysis Methods for CyTOF Data
Arend, L.; Bernett, J.; Manz, Q.; Klug, M.; Lazareva, O.; Baumbach, J.; Bongiovanni, D.; List, M.
10.1101/2021.08.09.455609 — bioinformatics — Posted on 2021-08-09
2829 A broadly neutralizing biparatopic Nanobody protects mice from lethal challenge with SARS-CoV-2 variants of concern
Wagner, T. R.; Schnepf, D.; Beer, J.; Klingel, K.; Ruetalo, N.; Kaiser, P. D.; Junker, D.; Sauter, M.; Traenkle, B.; Frecot, D. I.; Becker, M.; Schneiderhan-Marra, N.; Ohnemus, A.; Schwemmle, M.; Schindler, M.; Rothbauer, U.
10.1101/2021.08.08.455562 — biochemistry — Posted on 2021-08-09
2830 A gene-by-gene mosaic of dosage compensation strategies on the human X chromosome
San Roman, A. K.; Godfrey, A. K.; Skaletsky, H.; Bellott, D. W.; Groff, A. F.; Blanton, L. V.; Hughes, J. F.; Brown, L.; Phou, S.; Buscetta, A.; Kruszka, P.; Banks, N.; Dutra, A.; Pak, E.; Lasutschinkow, P. C.; Keen, C.; Davis, S. M.; Tartaglia, N. R.; Samango-Sprouse, C.; Muenke, M.; Page, D. C.
10.1101/2021.08.09.455676 — genetics — Posted on 2021-08-09
2835 The miR-430 locus with extreme promoter density is a transcription body organizer, which facilitates long range regulation in zygotic genome activation
Hadzhiev, Y.; Wheatley, L.; Cooper, L.; Ansaloni, F.; Whalley, C.; Chen, Z.; Gustincich, S.; Sanges, R.; Burgess, S. M.; Beggs, A. D.; Mueller, F. D.
10.1101/2021.08.09.455629 — developmental biology — Posted on 2021-08-09
2836 Integrative annotation of genomic features reveal functional elements and epigenetic landscapes in the developing zebrafish
Baranasic, D.; Hoertenhuber, M.; Balwierz, P.; Zehnder, T.; Mukarram, A. K.; Nepal, C.; Varnai, C.; Hadzhiev, Y.; Jimenez-Gonzalez, A.; Li, N.; Wragg, J. W.; D'Orazio, F.; Diaz, N.; Hernandez-Rodriguez, B.; Chen, Z.; Stoiber, M.; Dong, M.; Stevens, I.; Ross, S. E.; Eagle, A.; Martin, R.; Obasaju, P.; Rastegar, S.; McGarvey, A. C.; Kopp, W.; Chambers, E.; Wang, D.; Kim, H. K.; Acemel, R. D.; Naranjo, S.; Lapinski, M.; Chong-Morrison, V.; Mathavan, S.; Peers, B.; Sauka-Spengler, T.; Vingron, M.; Carninci, P.; Ohler, U.; Lacadie, S. A.; Burgess, S.; Winata, C.; van Eeden, F.; Vaquerizas, J. M.; G
10.1101/2021.08.09.454869 — developmental biology — Posted on 2021-08-09
2839 Global prediction of candidate R-loop binding and R-loop regulatory proteins
Fournier, L.-A.; Kumar, A.; Smith, T.; Su, E.; Moksa, M.; Hirst, M.; Stirling, P. C.
10.1101/2021.08.09.454968 — cell biology — Posted on 2021-08-09
2840 Who is the best surrogate for germ stem cell transplantation in fish?
Franek, R.; Cheng, Y.; Fucikova, M.; Kaspar, V.; Xie, X.; Shah, M. A.; Linhart, O.; Sauman, I.; Psenicka, M.
10.1101/2021.08.09.455047 — cell biology — Posted on 2021-08-09
2841 A Library Of Induced Pluripotent Stem Cells From Clinically Well-Characterized, Diverse Healthy Human Individuals
Schaniel, C.; Dhanan, P.; Hu, B.; Xiong, Y.; Raghunandan, T.; Gonzalez, D. M.; D'Souza, S. L.; Yadaw, A.; Hansen, J.; Jayaraman, G.; Mathew, B.; Machado, M.; Berger, S.; Tripodi, J.; Najfeld, V.; Garg, J.; Miller, M.; Lynch, C.; Michelis, K.; Tangirala, N.; Weerahandi, H.; Beaumont, K. G.; Thomas, D. C.; Sebra, R.; Mahajan, M.; Schadt, E.; Vidovic, D.; Schuerer, S. C.; Goldfarb, J.; Azeloglu, E. U.; Birtwistle, M. R.; Sobie, E. A.; Kovacic, J. C.; Dubois, N. C.; Iyengar, R.
10.1101/2020.10.29.360909 — cell biology — Posted on 2021-08-09
2842 Transcriptome profiling of Candidatus Liberibacter asiaticus in citrus and psyllids
De Francesco, A.; Lovelace, A.; Shaw, D.; Qiu, M.; Wang, Y.; Gurung, F.; Ancona, V.; Wang, C.; Levy, A.; Jiang, T.; Ma, W.
10.1101/2021.08.09.455679 — microbiology — Posted on 2021-08-09
2843 Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles
Mu, Z.; Wiehe, K.; Saunders, K. O.; Henderson, R.; Cain, D. W.; Parks, R.; Martik, D.; Mansouri, K.; Edwards, R. J.; Newman, A.; Lu, X.; Xia, S.-M.; Bonsignori, M.; Montefiori, D.; Han, Q.; Venkatayogi, S.; Evangelous, T.; Wang, Y.; Rountree, W.; Tam, Y.; Barbosa, C.; Alam, S. M.; Williams, W. B.; Pardi, N.; Weissman, D.; Haynes, B. F.
10.1101/2021.08.09.455714 — immunology — Posted on 2021-08-09
2844 Genome sequences of Aegilops species of section Sitopsis reveal phylogenetic relationships and provide resources for wheat improvement
Avni, R.; Lux, T.; Minz-Dub, A.; Millet, E.; Sela, H.; Distelfeld, A.; Deek, J.; Yu, G.; Steuernagel, B.; Pozniak, C.; Ens, J.; Gundlach, H.; Mayer, K. F. X.; Himmelbach, A.; Stein, N.; Mascher, M.; Spannagl, M.; Wulff, B. B.; Sharon, A.
10.1101/2021.08.09.455628 — plant biology — Posted on 2021-08-09
2845 A Tethered Ligand Assay to Probe SARS-CoV-2:ACE2 Interactions
Bauer, M. S.; Gruber, S.; Hausch, A.; Milles, L. F.; Nicolaus, T.; Schendel, L. C.; Lopez Navajas, P.; Procko, E.; Lietha, D.; Bernardi, R. C.; Gaub, H. E.; Lipfert, J.
10.1101/2021.08.08.455468 — biophysics — Posted on 2021-08-09
2846 Reprogramming of the intestinal epithelial-immune cell interactome during SARS-CoV-2 infection
Poletti, M.; Treveil, A.; Gul, L.; Modos, D.; Madgwick, M.; Olbei, M.; Bohar, B.; Valdeolivas, A.; Turei, D.; Verstockt, B.; Triana, S.; Alexandrov, T.; Saez-Rodriguez, J.; Stanifer, M. L.; Boulant, S.; Korcsmaros, T.
10.1101/2021.08.09.455656 — bioinformatics — Posted on 2021-08-09
2849 Marine gregarine genomes illuminate current understanding of apicomplexan glideosome
Boisard, J.; Duvernois-Berthet, E.; Duval, L.; Schrevel, J.; Guillou, L.; Labat, A.; Le Panse, S.; Prensier, G.; Ponger, L.; Florent, I.
10.1101/2021.08.09.454911 — genomics — Posted on 2021-08-09
2853 NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and suppresses PDAC initiation
Cobo, i.; Paliwal, S.; Melia-Aloma, J.; Torres, A.; Martinez-Villarreal, J.; Garcia, F.; Millan, I.; del Pozo, N.; Park, J.-C.; MacDonald, R. J.; Munoz, J.; Real, F. X.
10.1101/2021.08.09.455477 — cell biology — Posted on 2021-08-09
2855 Surveying the global landscape of post-transcriptional regulators
Reynaud, K.; McGeachy, A. M.; Noble, D.; Meacham, Z. A.; Ingolia, N.
10.1101/2021.08.09.455688 — molecular biology — Posted on 2021-08-09
2856 The obesity-linked human lncRNA AATBC regulates adipocyte plasticity by stimulating mitochondrial dynamics and respiration
Giroud, M.; Kotschi, S.; Kwon, Y.; Le Thuc, O.; Hoffmann, A.; Gil-Lozano, M.; Karbiener, M.; Higareda-Almaraz, J. C.; Khani, S.; Tews, D.; Fischer-Posovszky, P.; Sun, W.; Dong, H.; Ghosh, A.; Wolfrum, C.; Wabitsch, M.; Virtanen, K. A.; Blüher, M.; Nielsen, S.; Zeigerer, A.; Garcia-Caceres, C.; Scheideler, M.; Herzig, S.; Bartelt, A.
10.1101/2021.08.09.455681 — molecular biology — Posted on 2021-08-09
2857 Acetylation regulates the oligomerization state and activity of RNase J, the major ribonuclease of Helicobacter pylori
Tejada-Arranz, a.; Bouilloux-Lafont, M.; PEI, X.-Y.; Douche, T.; Matondo, M.; Williams, A.; Raynal, B.; Luisi, B.; DE REUSE, H.
10.1101/2021.08.09.455701 — microbiology — Posted on 2021-08-09
2858 NAD kinase controls antibiotic susceptibility and pathogenic potential in Staphylococcus aureus
Leseigneur, C.; Boucontet, L.; Gorgette, O.; Thouvenot, C.; Colucci-Guyon, E.; Dussurget, O.
10.1101/2021.08.09.455706 — microbiology — Posted on 2021-08-09
2860 Towards improved resistance of Corynebacterium glutamicum against nisin
Weixler, D.; Goldbeck, O.; Seibold, G. M.; Eikmanns, B. J.; Riedel, C. U.
10.1101/2021.08.09.454123 — microbiology — Posted on 2021-08-09
2861 Broad neutralizing nanobody against SARS-CoV-2 engineered from pre-designed synthetic library
Liu, Q.; Cai, C.; Huang, Y.; Zhou, L.; Guan, Y.; Fu, S.; Lin, Y.; Yang, T.; Liang, X.; Wang, N.; Zhang, F.; Sun, Q.; Bai, Y.; Chen, Y.; Yan, H.; Zhang, Z.; Lan, K.; Chen, Y.; Li, X.; Hou, S.-C.; Xiong, Y.
10.1101/2021.08.07.455523 — microbiology — Posted on 2021-08-09
2864 SIGNR1 promotes immune dysfunction in systemic candidiasis by modulating neutrophil lifespan via T cell-derived histones and G-CSF
Ioannou, M.; Hoving, D.; Aramburu, I. V.; De Vasconcelos, N. M.; Temkin, M. I.; Wang, Q.; Vernardis, S.; Demichev, V.; Tsourouktsoglou, T.-D.; Boeing, S.; Goldstone, R.; David, S.; Klaus Stahl, K.; Bode, C.; Ralser, M.; Papagiannopoulos, V.
10.1101/2021.08.09.455510 — immunology — Posted on 2021-08-09
2865 ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology
Gawish, R.; Starkl, P.; Pimenov, L.; Hladik, A.; Lakovits, K.; Oberndorfer, F.; Cronin, S. J. F.; Ohradanova-Repic, A.; Wirnsberger, G.; Agerer, B.; Endler, L.; Capraz, T.; Perthold, J. W.; Hagelkruys, A.; Montserrat, N.; Mirazimi, A.; Boon, L.; Stockinger, H.; Bergthaler, A.; Oostenbrink, C.; Penninger, J. M.; Knapp, S.
10.1101/2021.08.09.455606 — immunology — Posted on 2021-08-09
2867 3D single molecule localization microscopy reveals the topography of the immunological synapse at isotropic precision below 15 nm
Velas, L.; Brameshuber, M.; Huppa, J. B.; Kurz, E.; Dustin, M.; Zelger, P.; Jesacher, A.; Schuetz, G. J.
10.1101/2021.08.09.455230 — biophysics — Posted on 2021-08-09
2868 Molecular basis for redox control by the human cystine/glutamate antiporter System xc-.
Parker, J. L.; Deme, J. C.; Kolokouris, D.; Kuteyi, G.; Lea, S. M.; Newstead, S.
10.1101/2021.08.09.455631 — biochemistry — Posted on 2021-08-09
2870 Arabidopsis spliceosome factor SmD3 modulates immunity to Pseudomonas syringae infection
Golisz, A.; Krzyszton, M.; Stepien, M.; Dolata, J.; Piotrowska, J.; Szweykowska-Kulinska, Z.; Jarmolowski, A.; Kufel, J.
10.1101/2021.08.09.455611 — molecular biology — Posted on 2021-08-09
2872 Sex-specific tuning of modular muscle activation patterns for locomotion in young and older adults
Santuz, A.; Janshen, L.; Bruell, L.; Munoz-Martel, V.; Taborri, J.; Rossi, S.; Arampatzis, A.
10.1101/2021.08.09.455604 — neuroscience — Posted on 2021-08-09
2873 A DNA-structured mathematical model of cell-cycle progression in cyclic hypoxia
Celora, G. L.; Maini, P. K.; Byrne, H. M.; Hammond, E. M.; Bader, S. B.; Pitt-Francis, J.
10.1101/2021.08.09.455605 — cancer biology — Posted on 2021-08-09
2878 Mesoderm-Derived PDGFRA+ Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta
Chandrakanthan, V.; Rorimpandey, P.; Zanini, F.; Chacon, D.; Kang, Y. C.; Knezevic, K.; Huang, Y.; Qiao, Q.; Oliver, R. A.; Unnikrishnan, A.; Carter, D. R.; Lee, B.; Brownlee, C.; Power, C.; Mendez-Ferrer, S.; Enikolopov, G.; Walsh, W.; Gottgens, B.; Taoudi, S.; Beck, D.; Pimanda, J.
10.1101/2021.08.08.455592 — developmental biology — Posted on 2021-08-09
2879 Enterococcus spp. have higher fitness for survival, in a pH-dependent manner, in pancreatic juice among duodenal bacterial flora
Itoyama, S.; Noda, E.; Takamatsu, S.; Kondo, J.; Kawaguchi, R.; Shimosaka, M.; Fukuoka, T.; Motooka, D.; Nakamura, S.; Tanemura, M.; Mitsufuji, S.; Iwagami, Y.; Akita, H.; Tobe, T.; Kamada, Y.; Eguchi, H.; Miyoshi, E.
10.1101/2021.08.08.455373 — microbiology — Posted on 2021-08-09
2880 Testing the perilesional neuroplastic recruitment hypothesis in aphasia
DeMarco, A. T.; van der Stelt, C. M.; Paul, S. T.; Dvorak, E.; Lacey, E.; Snider, S.; Turkeltaub, P. E.
10.1101/2021.08.06.455431 — neuroscience — Posted on 2021-08-09
2882 Development of Functional Connectome Gradients during Childhood and Adolescence
Xia, Y.; Xia, M.; Liu, J.; Liao, X.; Lei, T.; Liang, X.; Zhao, T.; Shi, Z.; Sun, L.; Chen, X.; Men, W.; Wang, Y.; Pan, Z.; Luo, J.; Peng, S.; Chen, M.; Lei, H.; Tan, S.; Gao, J.; Qin, S.; Gong, G.; Tao, S.; Dong, Q.; He, Y.
10.1101/2021.08.08.455594 — neuroscience — Posted on 2021-08-09
2891 The quasi-universality of nestedness in the structure of quantitative plant-parasite interactions
Moury, B.; Audergon, J.-M.; Baudracco-Arnas, S.; BEN KRIMA, S.; Bertrand, F.; Boissot, N.; Buisson, M.; Caffier, V.; Cantet, M.; Chaneac, S.; Constant, C.; Delmotte, F.; Dogimont, C.; Doumayrou, J.; Fabre, F.; Fournet, S.; Grimault, V.; Jaunet, T.; Justafre, I.; Lefebvre, V.; Losdat, D.; MARCEL, T. C.; Montarry, J.; Morris, C. E.; Omrani, M.; Paineau, M.; Perrot, S.; Pilet-Nayel, M.-L.; Ruellan, Y.
10.1101/2021.03.03.433745 — pathology — Posted on 2021-08-09
2895 Phenotypic and genotypic parallel evolution in parapatric ecotypes of Senecio
James, M. E.; Melanie, W. J.; Bernal, D. M.; Liu, H.; North, H. L.; Engelstaedter, J.; Ortiz-Barrientos, D.
10.1101/2020.02.05.936450 — evolutionary biology — Posted on 2021-08-09
2896 Segmenting biological specimens from photos to understand the evolution of UV plumage in passerine birds
He, Y.; Cooney, C. R.; Varley, Z. K.; Nouri, L. O.; Moody, C. J. A.; Jardine, M. D.; Maddock, S.; Thomas, G. H.
10.1101/2021.07.22.453339 — evolutionary biology — Posted on 2021-08-09
2897 Somewhere I belong: phylogenetic comparative methods and machine learning to investigate the evolution of a species-rich lineage of parasites
Cruz-Laufer, A. J.; Pariselle, A.; Jorissen, M. W. P.; Muterezi Bukinga, F.; Al Assadi, A.; Van Steenberge, M.; Koblmueller, S.; Sturmbauer, C.; Smeets, K.; Artois, T.; Vanhove, M. P. M.
10.1101/2021.03.22.435939 — evolutionary biology — Posted on 2021-08-09
2899 Combined analysis of single cell RNA-Seq and ATAC-Seq data reveals putative regulatory toggles operating in native and iPS-derived retina.
Georges, A.; Lavergne, A.; Mandai, M.; Lepiemme, F.; Karim, L.; Demeulenaere, L.; Aguilar, D.; Schyns, M.; Nguyen, L.; Rakic, J.-M.; Takahashi, M.; Georges, M.; Takeda, H.
10.1101/2020.03.02.972497 — developmental biology — Posted on 2021-08-09
2901 Retroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular Damage
Branscome, H.; Khatkar, P.; Al Sharif, S.; Yin, D.; Jacob, S.; Cowen, M.; Kim, Y.; Erickson, J.; Brantner, C. A.; El-Hage, N.; Liotta, L. A.; Kashanchi, F.
10.1101/2020.12.31.424849 — cell biology — Posted on 2021-08-09
2903 A nitrogen source-regulated microprotein confers an alternative mechanism of G1/S transcriptional activation in budding yeast
Tollis, S.; Singh, J.; Thattikota, Y.; Palou, R.; Ghazal, G.; Coulombe-Huntington, J.; Tang, X.; Moore, S.; Blake, D.; Bonneil, E.; Royer, C. A.; Thibault, P.; Tyers, M.
10.1101/2020.04.20.033787 — cell biology — Posted on 2021-08-09
2904 An engineered, orthogonal auxin analog/AtTIR1(F79G) pairing improves both specificity and efficacy of the auxin degradation system in Caenorhabditis elegans
Hiils-Muckey, K.; Martinez, M. A. Q.; Stec, N.; Hebbar, S.; Saldanha, J.; Medwig-Kinney, T. N.; Moore, F. E. Q.; Ivanova, M.; Morao, A.; Ward, J. D.; Moss, E. G.; Ercan, S.; Zinovyeva, A.; Matus, D. Q.; Hammell, C.
10.1101/2021.08.06.455414 — molecular biology — Posted on 2021-08-09
2906 Maf/ham1-like pyrophosphatases of non-canonical nucleotides are host-specific partners of viral RNA-dependent RNA polymerases
Valli, A. A.; Garcia Lopez, R.; Ribaya, M.; Martinez, F. J.; Garcia Gomez, D.; Garcia, B.; Gonzalo, I.; Gonzalez, A.; Pasin, F.; Montanuy, I.; Rodriguez-Gonzalo, E.; Garcia, J. A.
10.1101/2021.05.18.444600 — molecular biology — Posted on 2021-08-09
2907 Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine Approach
Sonnenkalb, L.; Carter, J.; Spitaleri, A.; Iqbal, Z.; Hunt, M.; Malone, K.; Utpatel, C.; Cirillo, D. M.; Rodrigues, C.; Nilgiriwala, K. S.; the CRyPTIC Consortium, ; Fowler, P. W.; Merker, M.; Niemann, S.
10.1101/2021.03.19.436148 — microbiology — Posted on 2021-08-09
2908 An AI-guided signature reveals the nature of the shared proximal pathways of host immune response in MIS-C and Kawasaki disease
Sahoo, D.; Dattatray, G.; Shimizu, C.; Kim, J.; Khandelwal, S.; Tremoulet, A. H.; Kanegaye, J.; Pediatric Emergency Medicine Kawasaki Disease Research Group, ; Bocchini, J.; Das, S.; Burns, J. C.; Ghosh, P.
10.1101/2021.04.11.439347 — immunology — Posted on 2021-08-09
2909 Synaptic density and neuronal metabolic function measured by PET in the unilateral 6-OHDA rat model of Parkinson's disease
Raval, N. R.; Gudmundsen, F.; Juhl, M.; Andersen, I. V.; Speth, N. R.; Videbaek, A.; Petersen, I. N.; Mikkelsen, J. D.; Fisher, P. M.; Herth, M. M.; Plaven-Sigray, P.; Knudsen, G. M.; Palner, M.
10.1101/2021.05.27.444950 — neuroscience — Posted on 2021-08-09
2911 Single particle cryo-EM structure of the outer hair cell motor protein prestin
Butan, C.; Song, Q.; Bai, J.-p.; Tan, W.; Navaratnam, D. S.; Santos-Sacchi, J.
10.1101/2021.08.03.454998 — neuroscience — Posted on 2021-08-09
2914 Comparative cytogenomics reveals genome reshuffling and centromere repositioning in the legume tribe Phaseoleae
Montenegro, C.; Martins, L.; Bustamante, F. d. O.; Brasileiro-Vidal, A. C.; Pedrosa-Harand, A.
10.1101/2021.08.06.455448 — genomics — Posted on 2021-08-09
2919 Sex-specific body mass ageing trajectories in adult Asian elephants
Lalande, L. D.; Lummaa, V.; Aung, H. H.; Htut, W.; Nyein, U. K.; Berger, V.; Briga, M.
10.1101/2020.12.17.423208 — evolutionary biology — Posted on 2021-08-09
2920 Data science competition for cross-site delineation and classification of individual trees from airborne remote sensing data
Graves, S. J.; Marconi, S.; Stewart, D.; Harmon, I.; Weinstein, B. G.; Kanazawa, Y.; Scholl, V. M.; Joseph, M. B.; McClinchy, J.; Browne, L.; Sullivan, M. K.; Estrada-Villegas, S.; Tusa, E.; Wang, D. Z.; Singh, A.; Bohlman, S. A.; Zare, A.; White, E. P.
10.1101/2021.08.06.453503 — ecology — Posted on 2021-08-09
2922 Elamipretide (SS-31) Treatment Attenuates Age-Associated Post-Translational Modifications of Heart Proteins
Whitson, J. A.; Martin-Perez, M.; Zhang, T.; Gaffrey, M. J.; Merrihew, G. E.; Huang, E.; White, C. C.; Kavanagh, T. J.; Qian, W.-J.; Campbell, M. D.; MacCoss, M. J.; Marcinek, D. J.; Villen, J.; Rabinovitch, P. S.
10.1101/2021.08.06.455402 — cell biology — Posted on 2021-08-09
2923 Renal Angiotensinogen in Nonhuman Primates is Predominantly Liver-Derived
Kukida, M.; Cai, L.; Ye, D.; Sawada, H.; Katsumata, Y.; Franklin, M. K.; Hecker, P. I.; Campbell, K. S.; Danser, A. H. J.; Mullick, A. E.; Daugherty, A.; Temel, R. E.; Lu, H. S.
10.1101/2021.05.18.444555 — molecular biology — Posted on 2021-08-09
2924 Shotgun proteomic profiling of dormant, 'non-culturable' Mycobacterium tuberculosis
Nikitushkin, V. D.; Shleeva, M. O.; Loginov, D.; Dycka, F.; Sterba, J.; Kaprelyants, A.
10.1101/2021.08.06.455493 — microbiology — Posted on 2021-08-09
2925 Heightened virulence of Yersinia is associated with decreased function of the YopJ protein
Mares, C. A.; Lugo, F. P.; Albataineh, M.; Goins, B.; Newton, I.; Isberg, R. R.; Bergman, M.
10.1101/2021.03.22.436461 — microbiology — Posted on 2021-08-09
2926 Revealing how variations in antibody repertoires correlate with vaccine responses
Safonova, Y.; Shin, S. B.; Kramer, L.; Reecy, J.; Watson, C. T.; Smith, T. P. L.; Pevzner, P. A.
10.1101/2021.08.06.454618 — immunology — Posted on 2021-08-09
2928 Hematopoietic-SLC37A2 deficiency impairs M2 macrophage polarization and accelerates atherosclerosis in LDL receptor-deficient mice
Zhao, Q.; Wang, Z.; Meyers, A.; Madenspacher, J.; Zabalawi, M.; Boudyguina, E.; Hsu, F.-C.; McCall, C.; Furdui, C.; Parks, J.; Fessler, M.; Zhu, X.
10.1101/2021.08.06.455449 — immunology — Posted on 2021-08-09
2931 Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses
Bang, J. Y.; Sunstrum, J.; Garand, D.; Parfitt, G. M.; Woodin, M.; Inoue, W.; Kim, J.
10.1101/2021.08.06.455454 — neuroscience — Posted on 2021-08-09
2933 A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses
Gross, S. M.; Dane, M. A.; Smith, R. L.; Devlin, K.; Mclean, I.; Derrick, D.; Mills, C.; Subramanian, K.; London, A.; Torre, D.; Erdem, C.; Lyons, N.; Natoli, T.; Pessa, S.; Lu, X.; Mullahoo, J.; Li, J.; Adam, M.; Wassie, B.; Liu, M.; Kilburn, D. F.; Liby, T.; Bucher, E.; Sanchez-Aguila, C.; Daily, K.; Omberg, L.; Wang, Y.; Jacobson, C.; Yapp, C.; Chung, M.; Vidovic, D.; Lu, Y.; Schurer, S.; Lee, A.; Pillai, A.; Subramanian, A.; Papanastasiou, M.; Fraenkel, E.; Feiler, H.; Mills, G. B.; Jaffe, J.; Ma'ayan, A.; Birtwistle, M. R.; Sorger, P. K.; Korkola, J. E.; Gray, J. W.; Heiser, L. M.
10.1101/2021.08.06.455429 — systems biology — Posted on 2021-08-09
2936 Apoplastic effector candidates of a foliar forest pathogen trigger cell death in host and non-host plants
Hunziker, L.; Tarallo, M.; Gough, K.; Guo, M.; Hargreaves, C.; Loo, T. S.; McDougal, R. L.; Mesarich, C. H.; Bradshaw, R. E.
10.1101/2021.08.06.455341 — plant biology — Posted on 2021-08-09
2939 Ciliary IFT88 safeguards coordinated epiphyseal vascularisation, resorption and ossification from disruptive physiological mechanical forces
Coveney, C. R.; Samvelyan, J.; Miotla-Zarebska, J.; Carnegie, J.; Chang, E.; Corrin, J.; Coveney, T.; Stott, B.; Parisi, I.; Duarte, C.; Vincent, T. L.; Staines, K. A.; Wann, A. K.
10.1101/2021.08.06.455437 — physiology — Posted on 2021-08-09
2940 Titin switches from an extensible spring to a mechanical rectifier upon muscle activation
Squarci, C.; Bianco, P.; Reconditi, M.; Caremani, M.; Narayanan, T.; Malnasi Csizmadia, A.; Linari, M.; Lombardi, V.; Piazzesi, G.
10.1101/2021.08.06.455239 — physiology — Posted on 2021-08-09
2942 Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes
Doherty, L. M.; Mills, C. E.; Boswell, S. A.; Liu, X.; Hoyt, C. T.; Gyori, B. M.; Buhrlage, S. J.; Sorger, P. K.
10.1101/2021.08.06.455458 — cancer biology — Posted on 2021-08-09
2943 Viscoelasticity and Noise Properties Reveal the Formation of Biomemory in Cells
Bakalis, E.; Gavriil, V.; Cefalas, A.-C.; Kollia, Z.; Zerbetto, F.; Sarantopoulou, E.
10.1101/2021.08.06.455392 — biophysics — Posted on 2021-08-09
2946 Impact of sickle cell trait hemoglobin on the intraerythrocytic transcriptional program of Plasmodium falciparum
Saelens, J. W.; Petersen, J. E. V.; Freedman, E.; Moseley, R. C.; Konate, D.; Diakite, S. A. S.; Traore, K.; Vance, N.; Fairhurst, R. M.; Diakite, M.; Haase, S. B.; Taylor, S. M.
10.1101/2021.08.06.455439 — genetics — Posted on 2021-08-09
2952 The Global Virome in One Network (VIRION): an atlas of vertebrate-virus associations
Carlson, C. J.; Gibb, R. J.; Albery, G. F.; Brierley, L.; Connor, R.; Dallas, T.; Eskew, E. A.; Fagre, A. C.; Farrell, M. J.; Frank, H. K.; Muylaert, R. d. L.; Poisot, T.; Rasmussen, A.; Ryan, S. J.; Seifert, S.
10.1101/2021.08.06.455442 — microbiology — Posted on 2021-08-09
2954 BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen
Xia, Y.; Sandor, K.; Pai, J. A.; Daniel, B.; Raju, S.; Wu, R.; Hsiung, S.; Qi, Y.; Yangdon, T.; Okamoto, M.; Schreiber, R. D.; Murphy, K. M.; Satpathy, A. T.; Egawa, T.
10.1101/2021.08.06.455141 — immunology — Posted on 2021-08-09
2957 Powerful eQTL mapping through low coverage RNA sequencing
Schwarz, T.; Boltz, T.; Hou, K.; Bot, M.; Duan, C.; Olde Loohuis, L.; Boks, M. P.; Kahn, R. S.; Ophoff, R. A.; Pasaniuc, B.
10.1101/2021.08.08.455466 — genomics — Posted on 2021-08-09
2958 Extent and complexity of RNA processing in the development of honey bee queen and worker castes revealed by Nanopore direct RNA sequencing
He, X. J.; Barron, A. B.; Yang, L.; Chen, H.; He, Y. Z.; Zhang, L. Z.; Huang, Q.; Wang, Z. L.; Wu, X. B.; Yan, W. Y.; Zeng, Z. J.
10.1101/2021.08.08.455492 — developmental biology — Posted on 2021-08-09
2959 SIRT5 is the desuccinylase of LDHA as novel cancer metastatic stimulator in aggressive prostate cancer
Kwon, O. K.; Bang, I. H.; Choi, S. Y.; Jeon, J. M.; Na, A. Y.; Gao, Y.; Cho, S. S.; Ki, S. H.; Chpe, Y.; Lee, J. N.; Ha, Y.-S.; Bae, E.; Kwon, T. G.; Park, B.-H.; Lee, S.
10.1101/2021.08.08.455585 — cancer biology — Posted on 2021-08-09
2963 The gut bacteria of an invasive amphibian respond to the dual challenges of range-expansion and parasite attack
Zhou, J.; Nelson, T. M.; Rodriguez Lopez, C.; Zhou, S. J.; Ward-Fear, G.; Stuart, K. C.; Shine, R.; Rollins, L. A.
10.1101/2020.11.16.385690 — microbiology — Posted on 2021-08-08
2964 A warmer growing season triggers earlier following spring phenology
Gu, H.; Qiao, Y.; Xi, Z.; Rossi, S.; G. Smith, N.; Liu, J.; Chen, L.
10.1101/2021.08.08.455549 — ecology — Posted on 2021-08-08
2965 Cross-dataset reproducibility of human retinotopic maps
Himmelberg, M. M.; Kurzawski, J. W.; Benson, N. C.; Pelli, D. G.; Carrasco, M.; Winawer, J.
10.1101/2021.04.12.439348 — neuroscience — Posted on 2021-08-08
2969 Cell type determination for cardiac differentiation occurs soon after seeding of human induced pluripotent stem cells
Jiang, C. L.; Goyal, Y.; Jain, N.; Wang, Q.; Truitt, R. E.; Cote, A. J.; Emert, B.; Mellis, I. A.; Kiani, K.; Yang, W.; Jain, R.; Raj, A.
10.1101/2021.08.08.455532 — genomics — Posted on 2021-08-08
2970 Mechanisms of ecological divergence with gene flow in a reef-building coral on an isolated atoll in Western Australia
Thomas, L.; Underwood, J.; Rose, N. H.; Fuller, Z. L.; Dugal, L.; Grimaldi, C.; Richards, Z. T.; Cooke, I. R.; Palumbi, S. R.; Gilmour, J.
10.1101/2021.08.08.455318 — genomics — Posted on 2021-08-08
2973 Tankyrase interacts with the allosteric site of glucokinase and inhibits its glucose-sensing function in the beta cell
Chi, N.-W.; Eisemann, T.; Yeh, T.-Y. J.; Roy, S.; Chi, T. J.; Lu, S. H.; Pascal, J. M.; Osborn, O.
10.1101/2021.08.08.454510 — cell biology — Posted on 2021-08-08
2974 The Cell Adhesion Molecule TMIGD1 Binds to Moesin and Regulates Tubulin Acetylation and Cell Migration
Rahimi, N.; HO, R.; Chandler, K.; De La Cena, K.; Amraei, R.; Mitchel, A.; Engblom, N.; Costello, C.
10.1101/2021.08.08.455580 — cell biology — Posted on 2021-08-08
2975 Induction of cross-reactive antibody responses against the RBD domain of the spike protein of SARS-CoV-2 by commensal microbiota
Ninnemann, J.; Budzinski, L.; Bondareva, M.; Witkowski, M.; Angermair, S.; Kreye, J.; Durek, P.; Reincke, M.; Sanchez-Sendin, E.; Yilmaz, S.; Sempert, T.; Heinz, G. A.; Tizian, C.; Raftery, M.; Schoenrich, G.; Matyushkina, D.; Smirnov, I.; Govorun, V.; Schrezenmeier, E. V.; Doerner, T.; Zocche, S.; Viviano, E.; Sehmsdorf, K. J.; Chang, H.-D.; Enghard, P.; Treskatsch, S.; Radbruch, A.; Diefenbach, A.; Pruess, H.; Mashreghi, M.-F.; Kruglov, A.
10.1101/2021.08.08.455272 — microbiology — Posted on 2021-08-08
2978 Transmit Field Bias Correction of T1w/T2w Myelin Maps
Glasser, M. F.; Coalson, T. S.; Harms, M. P.; Baum, G. L.; Autio, J. A.; Auerbach, E. A.; Xu, J.; Greve, D. N.; Yacoub, E.; Van Essen, D. C.; Bock, N. A.; Hayashi, T.
10.1101/2021.08.08.455570 — neuroscience — Posted on 2021-08-08
2981 Homologous organization of cerebellar pathways to sensory, motor, and associative forebrain
Pisano, T. J.; Dhanerawala, Z. M.; Kislin, M.; Bakshinskaya, D.; Engel, E. A.; Hansen, E. J.; Hoag, A. T.; Lee, J.; de Oude, N. L.; Umadevi Venkataraju, K.; Verpeut, J. L.; Hoebeek, F. E.; Richardson, B. D.; Boele, H.-J.; Wang, S. S.- H.
10.1101/2020.03.06.979153 — neuroscience — Posted on 2021-08-08
2984 High genetic barrier to escape from human polyclonal SARS-CoV-2 neutralizing antibodies
Schmidt, F.; Weisblum, Y.; Rutkowska, M.; Poston, D.; Da Silva, J.; Zhang, F.; Bednarski, E.; Cho, A.; Schaefer-Babajew, D.; Gaebler, C.; Caskey, M.; Nussenzweig, M. C.; Hatziioannou, T.; Bieniasz, P. D.
10.1101/2021.08.06.455491 — microbiology — Posted on 2021-08-08
2985 Broad-spectrum in vitro antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified monophosphate prodrug of remdesivir parent nucleoside (GS-441524)
Lo, M. K.; Shrivastava-Ranjan, P.; Chatterjee, P.; Flint, M.; Beadle, J. R.; Valiaeva, N.; Schooley, R.; Hostetler, K. Y.; Montgomery, J.; Spiropoulou, C. F.
10.1101/2021.08.06.455494 — pharmacology and toxicology — Posted on 2021-08-08
2986 The emergence of highly fit SARS-CoV-2 variants accelerated by recombination
Garvin, M. R.; Prates, E. T.; Romero, J.; Cliff, A.; Gazolla, J. G. F. M.; Pickholz, M.; Pavicic, M.; Jacobson, D.
10.1101/2021.08.03.454981 — evolutionary biology — Posted on 2021-08-08
2991 Autologous human immunocompetent white adipose tissue-on-chip
Rogal, J.; Xu, R.; Roosz, J.; Teufel, C.; Cipriano, M.; Eisler, W.; Weiss, M.; Schenke-Layland, K.; Loskill, P.
10.1101/2021.08.08.455559 — bioengineering — Posted on 2021-08-08
2993 Machine Learning Optimization of Photosynthetic Microbe Cultivation and Recombinant Protein Production
Gamble, C.; Bryant, D.; Carrieri, D.; Bixby, E.; Dang, J.; Marshall, J.; Doughty, D.; Colwell, L.; Berndl, M.; Roberts, J.; Frumkin, M.
10.1101/2021.08.06.453272 — bioengineering — Posted on 2021-08-08
2994 Unravelling Form and Function: Improved function of engineered cardiac tissue through extra-cellular anisotropy
Cyr, J. A.; Colzani, M.; Bayraktar, S.; Graup, V.; Farndale, R.; Sinha, S. A.; Best, S. M.; Cameron, R. E.
10.1101/2021.08.06.455438 — bioengineering — Posted on 2021-08-08
3000 Charting Brain Growth and Aging at High Spatial Precision
Rutherford, S.; Fraza, C.; Dinga, R.; Kia, S. M.; Wolfers, T.; Zabihi, M.; Berthet, P.; Worker, A.; Verdi, S.; Andrews, D.; Han, L.; Bayer, J.; Dazzan, P.; McGuire, P.; Mocking, R. T.; Schene, A.; Sripada, C.; Tso, I. F.; Duval, E. R.; Chang, S.-E.; Pennix, B. W.; Heitzeg, M. M.; Burt, S. A.; Hyde, L.; Amaral, D.; Nordahl, C. W.; Andreasssen, O. A.; Westlye, L. T.; Zahn, R.; Ruhe, H. G.; Beckmann, C.; Marquand, A. F.
10.1101/2021.08.08.455487 — neuroscience — Posted on 2021-08-08
3002 Ploidetect enables pan-cancer analysis of the causes and impacts of chromosomal instability
Culibrk, L.; Grewal, J. K.; Pleasance, E. D.; Williamson, L.; Mungall, K.; Laskin, J.; Marra, M. A.; Jones, S. J.
10.1101/2021.08.06.455329 — cancer biology — Posted on 2021-08-08
3003 Comparative untargeted metabolomic profiling of induced mitochondrial fusion in pancreatic cancer
Nguyen, N. D.; Yu, M.; Reddy, V. Y.; Acevedo-Diaz, A. C.; Mesarick, E. C.; Abi Jaoude, J.; Yuan, M.; Asara, J. M.; Taniguchi, C. M.
10.1101/2021.08.06.455450 — cancer biology — Posted on 2021-08-08
3004 Exploration of novel αβ-protein folds through de novo design
Minami, S.; Kobayashi, N.; Sugiki, T.; Nagashima, T.; Fujiwara, T.; Koga, R.; Chikenji, G.; Koga, N.
10.1101/2021.08.06.455475 — biophysics — Posted on 2021-08-08
3006 AMES: Automated evaluation of sarcomere structures in cardiomyocytes
Hillemanns, M.; Lemcke, H.; David, R.; Martinetz, T.; Wolfien, M.; Wolkenhauer, O.
10.1101/2021.08.06.455455 — bioinformatics — Posted on 2021-08-08
3007 ChemPLAN-Net: A deep learning framework to find novel inhibitor fragments for proteins
Suarez Vasquez, M. A.; Xue, M.; Lam, J. H.; Goonetilleke, E. C.; Gao, X.; Huang, X.
10.1101/2021.08.08.455375 — bioinformatics — Posted on 2021-08-08
3008 CRISPR-mediated insertion of a chimeric antigen receptor produces nonviral T cell products capable of inducing solid tumor regression
Mueller, K.; Piscopo, N.; Forsberg, M.; Saraspe, L.; Das, A.; Russell, B.; Smerchansky, M.; Shi, L.; Ali, A.; Lazzarotto, C.; Tsai, S.; Capitini, C. M.; Saha, K.
10.1101/2021.08.06.455489 — bioengineering — Posted on 2021-08-08
3009 Automated tracking reveals the social network of beach mice and their burrows
Bedford, N. L.; Gable, J. T.; Hu, C. K.; Wooldridge, T. B.; Sokolov, N. A.; Lassance, J.-M.; Hoekstra, H. E.
10.1101/2021.08.07.455531 — animal behavior and cognition — Posted on 2021-08-08
3010 The initial response of females towards congeneric males matches the propensity to hybridize in Ophthalmotilapia.
Van Steenberge, M.; Jublier, N.; Kever, L.; Gresham, S.; Derycke, S.; Snoeks, J.; Parmentier, E.; Poncin, P.; Verheyen, E.
10.1101/2021.08.07.455508 — animal behavior and cognition — Posted on 2021-08-08
3013 Enhanced soil quality after forest conversion to vegetable cropland and tea plantation has contrasting effects on soil microbial structure and functions
Fan, L.; Shao, G.; Pan, Y.; Dai, H.; Zhang, L.; Yan, P.; Zou, Z.; Zhang, Z.; Xu, J.; Zamanian, K.; Dorodnikov, M.; Li, X.; Gui, H.; Han, W.
10.1101/2021.08.07.455503 — ecology — Posted on 2021-08-08
3014 Representing the sediment retention ecosystem service within an ecosystem account of the Mitchell catchment
McMahon, J. M.; Hasan, S.; Brooks, A.; Curwen, G.; Dyke, J.; Saint Ange, C.; Smart, J. C. R.
10.1101/2021.08.06.455476 — ecology — Posted on 2021-08-08
3018 Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine Approach
Sonnenkalb, L.; Carter, J.; Spitaleri, A.; Iqbal, Z.; Hunt, M.; Malone, K.; Utpatel, C.; Cirillo, D. M.; Rodrigues, C.; Nilgiriwala, K. S.; the CRyPTIC Consortium, ; Fowler, P. W.; Merker, M.; Niemann, S.
10.1101/2021.03.19.436148 — microbiology — Posted on 2021-08-08
3019 Metataxonomic review to elucidate the role of the microbiome in Celiac disease across the gastrointestinal tract
Arcila Galvis, J. E.; Loria-Kohen, V.; Ramirez de Molina, A.; Castillo de Santa Pau, E.; Marcos-Zambrano, L. J.
10.1101/2021.08.08.455560 — microbiology — Posted on 2021-08-08
3020 Augmenting Neutralization breadth against Diverse HIV-1 by increasing the Ab-Ag interface on V2
Gao, N.; Gai, Y.; Meng, L.; Wang, C.; Wang, W.; Li, X.; Gu, T.; Louder, M. K.; Doria-Rose, N. A.; Wiehe, K.; Nazzari, A. F.; Olia, A. S.; Gorman, J.; Rawi, R.; Wu, W.; Smith, C.; Khant, H.; Val, N. d.; Yu, B.; Luo, J.; Niu, H.; Tsybovsky, Y.; Liao, H.; Kepler, T. B.; Kwong, P. D.; Mascola, J. R.; Qin, C.; Zhou, T.; Yu, X.; Gao, F.
10.1101/2021.08.07.455519 — immunology — Posted on 2021-08-08
3023 Binding of Monomeric and Polymeric Alzheimers Aβ peptides to Exosomes
Coughlan, C.; Lindenberger, J.; Jacot, J.; Johnson, N. R.; Anton, P.; Bevers, S.; Graner, M.; Potter, H.
10.1101/2021.08.06.455470 — neuroscience — Posted on 2021-08-08
3025 Visual association cortex links cues with conjunctions of reward and locomotor contexts
McGuire, K. L.; Amsalem, O.; Sugden, A. U.; Ramesh, R. N.; Burgess, C. R.; Andermann, M. L.
10.1101/2021.08.07.453879 — neuroscience — Posted on 2021-08-08
3028 Recombinant NAGLU-IGF2 prevents physical and neurological disease and improves survival in Sanfilippo B syndrome
Le, S. Q.; Kan, S.-h.; Nunez, M.; Dearborn, J.; Wang, F.; LI, S.; Snella, L.; Jens, J. K.; Valentine, B. N.; Nelvagal, H. R.; Sorensen, A.; Cooper, J. D.; Chou, T.-F.; Ellinwood, N. M.; Smith, J. D.; Sands, M. S.; Dickson, P.
10.1101/2021.08.06.455469 — neuroscience — Posted on 2021-08-08
3029 Temporal dynamics of neural responses in human visual cortex
Groen, I. I. A.; Piantoni, G.; Montenegro, S.; Flinker, A.; Devore, S.; Devinsky, O.; Doyle, W.; Ramsey, N.; Petridou, N.; Winawer, J. A.
10.1101/2021.08.08.455547 — neuroscience — Posted on 2021-08-08
3030 Temporal change in chromatin accessibility predicts regulators of nodulation in Medicago truncatula
Knaack, S. A.; Conde, D.; Balmant, K. M.; Irving, T. B.; Maia, L. G.; Triozzi, P. M.; Dervinis, C.; Pereira, W. J.; Maeda, J.; Chakraborty, S.; Schmidt, H. W.; Ane, J.-M.; Kirst, M.; Roy, S.
10.1101/2021.08.07.455463 — plant biology — Posted on 2021-08-08
3034 An Isogenic Cell Line Panel for Sequence-based Screening of Targeted Anti-cancer Drugs
Cook, A. L.; Wyhs, N.; Sur, S. B.; Ptak, B.; Popoli, M.; Dobbyn, L.; Papadopoulos, T.; Bettegowda, C.; Papadopoulos, N.; Vogelstein, B.; Zhou, S.; Kinzler, K. W.
10.1101/2021.08.06.455336 — cancer biology — Posted on 2021-08-08
3035 Direct observation of Hsp90-induced compaction in a protein chain
Mashaghi, A.; Moayed, F.; Koers, E. J.; Kramer, G.; Mayer, M. P.; Tans, S. J.
10.1101/2021.08.08.455546 — biophysics — Posted on 2021-08-08
3038 Topological morphogenesis of neuroepithelial organoids
Ishihara, K.; Mukherjee, A.; Gromberg, E.; Brugues, J.; Tanaka, E.; Julicher, F.
10.1101/2021.08.08.455385 — biophysics — Posted on 2021-08-08
3041 SeqScreen: Accurate and Sensitive Functional Screening of Pathogenic Sequences via Ensemble Learning
Balaji, A.; Kille, B.; Kappell, A. D.; Godbold, G. D.; Diep, M.; Elworth, L. R. A.; Qian, Z.; Albin, D.; Nasko, D. J.; Shah, N.; Pop, M.; Segarra, S.; Ternus, K. L.; Treangen, T. J.
10.1101/2021.05.02.442344 — bioinformatics — Posted on 2021-08-08
3045 Ccr4-Not complex reduces transcription efficiency in heterochromatin
Monteagudo, P.; Broenner, C.; Kohvaei, P.; Amedi, H.; Canzar, S.; Halic, M.
10.1101/2021.08.08.455218 — genomics — Posted on 2021-08-08
3046 Genomic constraints to drought adaptation
Ahrens, C. W.; Murray, K.; Mazanec, R. A.; Ferguson, S.; Bragg, J. G.; Jones, A.; Tissue, D. T.; Byrne, M.; Borevitz, J. O.; Rymer, P. D.
10.1101/2021.08.07.455511 — evolutionary biology — Posted on 2021-08-08
3048 A warmer growing season triggers earlier following spring phenology
gu, h.; qiao, y.; xi, z.; Rossi, S.; G. Smith, N.; liu, J.; Chen, L.
10.1101/2021.08.08.455549 — ecology — Posted on 2021-08-08
3049 Snrpb, the gene mutated in CCMS, is haploinsufficient and required for proper morphogenesis and splicing
Alam, S. S.; Kumar, S.; Beauchamp, M.-C.; Bareke, E.; Boucher, A.; Nzirorera, N.; Padilla, R.; Zhang, S. J.; Majewski, J.; Jerome-Majewska, L. A.
10.1101/2021.08.07.455514 — developmental biology — Posted on 2021-08-08
3057 Thalamo-hippocampal pathway regulates incidental memory load: insights from sex differences
Torromino, G.; Loffredo, V.; Cavezza, D.; Esposito, F.; Crevenna, A. H.; Gioffré, M.; De Risi, M.; Treves, A.; Griguoli, M.; De Leonibus, E.
10.1101/2021.08.07.453742 — neuroscience — Posted on 2021-08-08
3062 Deep learning based kcat prediction enables improved enzyme constrained model reconstruction
Li, F.; Yuan, L.; Lu, H.; Li, G.; Chen, Y.; Engqvist, M. K.; Kerkhoven, E. J.; Nielsen, J.
10.1101/2021.08.06.455417 — systems biology — Posted on 2021-08-08
3065 Cryo-EM Structures of Prestin and the Molecular Basis of Outer Hair Cell Electromotility
Bavi, N.; Clark, M. D.; Contreras, G. F.; Shen, R.; Reddy, B.; Milewski, W. M.; Perozo, E.
10.1101/2021.08.06.455374 — neuroscience — Posted on 2021-08-08
3066 Improving localization precision via restricting biomolecule confined stochastic motion in SMLM
Ni, J.; Cao, B.; Niu, G.; Xia, T.; Chen, D.; Zhang, W.; Zhang, Y.; Yuan, X.; Ni, Y.
10.1101/2021.03.16.435087 — biophysics — Posted on 2021-08-08
3069 Removing the ceiling on droplet microfluidics
Khor, J. W.; Lee, U. N.; Berthier, J.; Berthier, E.; Theberge, A. B.
10.1101/2021.07.29.454194 — bioengineering — Posted on 2021-08-07
3074 Hybrid Derivative of Cathelicidin and Human Beta Defensin-2 Against Gram-Positive Bacteria: A Novel Approach for the Treatment of Bacterial Keratitis
Ting, D. S. J.; Goh, E. T. L.; Mayandi, V.; Busoy, J.; Aung, T.; Periayah, M.; Nubile, M.; Mastropasqua, L.; Said, D.; Htoon, H.; Veluchamy, A.; Beuerman, R.; Lakshminarayanan, R.; Mohammed, I.; Dua, H.
10.1101/2021.04.22.440925 — microbiology — Posted on 2021-08-07
3076 Spatiotemporal dynamics of human microglia are linked with brain developmental processes across the lifespan
Menassa, D. A.; Muntslag, T. A. O.; Martin-Estebane, M.; Barry-Carroll, L.; Chapman, M. A.; Adorjan, I.; Tyler, T.; Turnbull, B.; Rose-Zerilli, M. J. J.; Nicoll, J. A. R.; Krsnik, Z.; Kostovic, I.; Gomez-Nicola, D.
10.1101/2021.08.07.455365 — neuroscience — Posted on 2021-08-07
3078 Type I photosynthetic reaction center in an anoxygenic phototrophic member of the Chloroflexota
Tsuji, J. M.; Shaw, N. A.; Nagashima, S.; Venkiteswaran, J. J.; Schiff, S. L.; Hanada, S.; Tank, M.; Neufeld, J. D.
10.1101/2020.07.07.190934 — microbiology — Posted on 2021-08-07
3079 Visual modulation of spectrotemporal receptive fields in mouse auditory cortex
Bigelow, J.; Morrill, R. J.; Olsen, T.; Bazarini, S. N.; Hasenstaub, A. R.
10.1101/2021.08.06.455445 — neuroscience — Posted on 2021-08-07
3081 Resistance to amitraz in the parasitic honey bee mite Varroa destructor is associated with mutations in the β-adrenergic-like octopamine receptor
Hernandez-Rodriguez, C. S.; Moreno-Marti, S.; Almecija, G.; Christmon, K.; Johnson, J. D.; Ventelon, M.; vanEngelsdorp, D.; Cook, S. C.; Gonzalez-Cabrera, J.
10.1101/2021.08.06.455389 — genetics — Posted on 2021-08-06
3084 The mouse bone metabolome is sexually dimorphic and is associated with whole bone strength
Welhaven, H. D.; Vahidi, G.; Walk, S. T.; Bothner, B.; Heveran, C. M.; June, R. K.
10.1101/2021.08.06.455423 — cell biology — Posted on 2021-08-06
3087 Ten-eleven translocation 1 Mediated-DNA Hydroxymethylation is Required for Myelination and Remyelination in the Mouse Brain
Zhang, M.; Wang, J.; Zhang, K.; Lu, G.; Liu, Y.; Ren, K.; Wang, W.; Xin, D.; Mao, H.; Xing, J.; Gao, X.; Jin, W.; Berry, K.; Wu, S.; Lu, Q. R.; Zhao, X.
10.1101/821496 — neuroscience — Posted on 2021-08-06
3092 The central nucleus of the amygdala and gustatory cortex assess affective valence during CTA learning and expression in male and female rats
Bernanke, A.; Burnette, E.; Murphy, J.; Hernandez, N.; Zimmerman, S.; Walker, Q. D.; Wander, R.; Sette, S.; Reavis, Z.; Francis, R.; Armstrong, C.; Risher, M.-L.; Kuhn, C.
10.1101/2021.05.04.442519 — animal behavior and cognition — Posted on 2021-08-06
3098 A clinically validated human saliva metatranscriptomic test for global systems biology studies
Toma, R.; Cai, Y.; Ogundijo, O.; Gline, S.; Demusaj, D.; Duval, N.; Torres, P.; Camacho, F.; Banavar, G.; Vuyisich, M.
10.1101/2021.08.03.454950 — microbiology — Posted on 2021-08-06
3099 Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults
Siranosian, B. A.; Brooks, E. F.; Andermann, T.; Rezvani, A. R.; Banaei, N.; Tang, H.; Bhatt, A. S.
10.1101/2021.03.12.435204 — microbiology — Posted on 2021-08-06
3106 Intra-Articular Delivery of an Indoleamine 2,3-Dioxygenase Galectin-3 Fusion Protein for Osteoarthritis Treatment in Male Lewis Rats
Partain, B. D.; Bracho-Sanchez, E.; Farhadi, S. A.; Yarmola, E. G.; Keselowsky, B. G.; Hudalla, G. A.; Allen, K. D.
10.1101/2021.07.21.453247 — bioengineering — Posted on 2021-08-06
3107 Characterizing Human Mesenchymal Stromal Cells Immune Modulatory Potency Using Targeted Lipidomic Profiling of Sphingolipids
DeVeaux, S. A.; Ogle, M. E.; Vyshnya, S.; Chiappa, N. F.; Leitmann, B.; Rudy, R.; Day, A.; Mortensen, L. J.; Kurtzberg, J.; Roy, K.; Botchwey, E.
10.1101/2021.06.01.446428 — bioengineering — Posted on 2021-08-06
3112 The Internal Structure of Metacommunities
Leibold, M. A.; Rudolf, J.; Blanchet, F. G.; De Meester, L.; Gravel, D.; Hartig, F.; Peres-Neto, P.; Shoemaker, L.; Chase, J.
10.1101/2020.07.04.187955 — ecology — Posted on 2021-08-06
3115 Early megakaryocyte lineage-committed progenitors in adult mouse bone marrow
Liu, Z.; Wang, J.; Xie, M.; Wu, P.; Ma, Y.; Zhang, S.; Wang, X.; Dong, F.; Cheng, H.; Zhu, P.; Han, M.; Ema, H.
10.1101/2021.08.06.455158 — cell biology — Posted on 2021-08-06
3116 Differential Expression of Alkaline Phosphatase and PHOSPHO1 in Bone from a Murine Model of Chronic Kidney Disease
Hsu, S.-N.; Stephen, L. A.; Dillon, S.; Milne, E.; Novak, A.; Millan, J. L.; Macrae, V. E.; Staines, K. A.; Farquharson, C.
10.1101/2021.08.06.455411 — cell biology — Posted on 2021-08-06
3117 Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA
Pla-Martin, D.; Sen, A.; Kallabis, S.; Nuechel, J.; Maliphol, K.; Hofmann, J.; Krueger, M.; Wiesner, R. J.
10.1101/2021.08.06.455397 — cell biology — Posted on 2021-08-06
3119 Environmental DNA from a small sample of reservoir water can tell volumes about its biodiversity.
Torres, A. L. Q.; Amaral, D. L. A. S.; Guimaraes, M.; Pinheiro, H. B.; Pereira, C. M.; de Castro, G. M.; Guerreiro, L. T. A.; Americo, J. A.; Rebelo, M. F.
10.1101/2021.08.06.455478 — molecular biology — Posted on 2021-08-06
3122 The actin nucleator Spir-1 is a virus restriction factor that promotes IRF3 activation
Torres, A. A.; Macilwee, S. L.; Rashid, A.; Cox, S. E.; Albarnaz, J. D.; Bonjardim, C. A.; Smith, G. L.
10.1101/2020.08.31.276659 — microbiology — Posted on 2021-08-06
3125 An engineered, orthogonal auxin analog/AtTIR1(F79G) pairing improves both specificity and efficacy of the auxin degradation system in Caenorhabditis elegans
Hiils-Muckey, K.; Martinez, M. A. Q.; Stec, N.; Hebbar, S.; Saldanha, J.; Medwig-Kinney, T. N.; Moore, F. E. Q.; Ivanova, M.; Moraro, A.; Ward, J. D.; Moss, E. G.; Ercan, S.; Zinovyeva, A.; Matus, D. Q.; Hammell, C.
10.1101/2021.08.06.455414 — molecular biology — Posted on 2021-08-06
3128 In vivo capture of bacterial cells by remote guiding
Rybkin, I. A.; Pinyaev, S. I.; Sindeeva, O. A.; German, S. V.; Koblar, M.; Pyataev, N. A.; Ceh, M.; Gorin, D. A.; Sukhorukov, G. B.; Lapanje, A.
10.1101/2021.08.06.455395 — microbiology — Posted on 2021-08-06
3132 Multispecies phase diagram reveals biophysical principles of bacterial biofilm architectures
Jeckel, H.; Diaz-Pascual, F.; Skinner, D. J.; Song, B.; Jimenez Siebert, E.; Jelli, E.; Vaidya, S.; Dunkel, J.; Drescher, K.
10.1101/2021.08.06.455416 — microbiology — Posted on 2021-08-06
3133 Controlled administration of aerosolized SARS-CoV-2 to K18-hACE2 transgenic mice uncouples respiratory infection and anosmia from fatal neuroinvasion
Fumagalli, V.; Rava, M.; Marotta, D.; Di Lucia, P.; Laura, C.; Sala, E.; Grillo, M.; Bono, E.; Giustini, L.; Perucchini, C.; Mainetti, M.; Sessa, A.; Garcia-Manteiga, J.; Donnici, L.; Manganaro, L.; Delbue, S.; Broccoli, V.; De Francesco, R.; D'Adamo, P.; Kuka, M.; Guidotti, L.; Iannacone, M.
10.1101/2021.08.06.455382 — immunology — Posted on 2021-08-06
3135 Knockout of circRNAs by base editing back-splice sites of circularized exons
Gao, X.; Ma, X.-K.; Li, X.; Li, G.-W.; Liu, C.-X.; Zhang, J.; Wang, Y.; Wei, J.; Chen, J.; Chen, L.-L.; Yang, L.
10.1101/2021.08.05.455347 — bioinformatics — Posted on 2021-08-06
3137 Epithelial Immunomodulation by Aerosolized Toll-like Receptor Agonists Attenuates Allergic Responsiveness in Mice
Goldblatt, D. L.; Valverde Ha, G.; Wali, S.; Kulkarni, V. V.; Longmire, M. K.; Jaramillo, A. M.; Chittuluru, R. P.; Fouts, A. M.; Martinez-Moczygemba, M.; Lei, J. T.; Huston, D. P.; Tuvim, M. J.; Dickey, B. F.; Evans, S. E.
10.1101/2021.08.05.455337 — immunology — Posted on 2021-08-06
3138 Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants
Tada, T.; Zhou, H.; Samanovic, M. I.; Dcosta, B. M.; Cornelius, A.; Mulligan, M. J.; Landau, N. R.
10.1101/2021.07.19.452771 — immunology — Posted on 2021-08-06
3139 Synaptic and mitochondrial plasticity associated with fear memory revealed by deep learning-based 3D reconstruction
Liu, J.; Qi, J.; Chen, X.; Li, Z.; Hong, B.; Ma, H.; Li, G.; Shen, L.; Liu, D.; Kong, Y.; Xie, Q.; Han, H.; Yang, Y.
10.1101/2021.08.05.455246 — neuroscience — Posted on 2021-08-06
3141 Impaired dynamics of brain precapillary sphincters and first order capillaries explains reduced neurovascular functions in aging
Cai, C.; Zambach, S. A.; Grubb, S.; Thomsen, K. J.; Lind, B. L.; Hald, B. O.; Loenstrup, M.; Nielsen, R. M.; Lauritzen, M. J.
10.1101/2021.08.05.455300 — neuroscience — Posted on 2021-08-06
3153 RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection
Marx, S.; Kuemmerer, B. M.; Gruetzner, C.; Kato, H.; Schlee, M.; Bartok, E.; Renn, M.; Hartmann, G.
10.1101/2021.08.06.455405 — immunology — Posted on 2021-08-06
3154 One mucosal administration of a live attenuated recombinant COVID-19 vaccine protects non-human primates from SARS-CoV-2
Tioni, M. F.; Jordan, R.; Silva Pena, A.; Garg, A.; Wu, D.; Phan, S. I.; Cheng, X.; Greenhouse, J.; Orekov, T.; Valentin, D.; Kar, S.; Pessaint, L.; Andersen, H.; Stobart, C. C.; Bloodworth, M. H.; Peebles, R. S.; Liu, Y.; Xie, X.; Shi, P.-Y.; Moore, M. L.; Tang, R. S.
10.1101/2021.07.16.452733 — immunology — Posted on 2021-08-06
3156 Interleukin-33 coordinates a microglial phagocytic response and limits corticothalamic excitability and seizure susceptibility
Han, R. T.; Vainchtein, I. D.; Schlachetzki, J. C. M.; Cho, F. S.; Dorman, L. C.; Johung, T.; Ahn, E.; Barron, J. T.; Inoue, H. N.; Joshi, A.; Molofsky, A. B.; Glass, C. K.; Paz, J. T.; Molofsky, A. V.
10.1101/2021.08.05.455250 — neuroscience — Posted on 2021-08-06
3159 Peptidergic modulation of fear responses by the Edinger-Westphal nucleus
Priest, M. F.; Freda, S. N.; Badong, D.; Dumrongprechachan, V.; Kozorovitskiy, Y.
10.1101/2021.08.05.455317 — neuroscience — Posted on 2021-08-06
3161 Naked mole-rat and Damaraland mole-rat exhibit lower respiration in mitochondria, cellular and organismal levels
Yap, K. N.; Wong, H. S.; Ramanathan, C.; Rodriguez-Wagner, C. A.; Roberts, M. D.; Freeman, D. A.; Buffenstein, R.; Zhang, Y.
10.1101/2021.08.05.455346 — physiology — Posted on 2021-08-06
3168 A general deep learning model for bird detection in high resolution airborne imagery
Weinstein, B. G.; Gardner, L.; Saccomanno, V.; Steinkraus, A.; Ortega, A.; Brush, K.; Yenni, G.; McKellar, A. E.; Converse, R.; Lippitt, C.; Wegmann, A.; Holmes, N. D.; Edney, A. J.; Hart, T.; Jessopp, M. J.; Clarke, R.; Marchowksi, D.; Senyondo, H.; Dotson, R.; White, E. P.; Frederick, P.; Ernest, S. K. M.
10.1101/2021.08.05.455311 — ecology — Posted on 2021-08-06
3170 The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2
Cathcart, A. L.; Havenar-Daughton, C.; Lempp, F. A.; Ma, D.; Schmid, M.; Agostini, M. L.; Guarino, B.; Di iulio, J.; Rosen, L.; Tucker, H.; Dillen, J.; Subramanian, S.; Sloan, B.; Bianchi, S.; Wojcechowskyj, J.; Zhou, J.; Kaiser, H.; Chase, A.; Lauron, E.; Montiel-Ruiz, M.; Spreafico, R.; Noack, J.; Czudnochowski, N.; Sahakyan, A.; Pinto, D.; Saliba, C.; Delotta, E.; Park, A.; Cameroni, E.; Ledoux, S.; Werts, A.; Colas, C.; Soriaga, L.; Telenti, A.; Purcell, L. A.; Hwang, S.; Snell, G.; Virgin, H. W.; Corti, D.; Hebner, C. M.
10.1101/2021.03.09.434607 — immunology — Posted on 2021-08-06
3172 Voltage imaging in Drosophila using a hybrid chemical-genetic rhodamine voltage reporter
Kirk, M.; Benlian, B.; Han, Y.; Gold, A.; Ravi, A.; Deal, P.; Molina, R.; Drobizhev, M.; Dickman, D.; Scott, K.; Miller, E.
10.1101/2021.08.05.455279 — neuroscience — Posted on 2021-08-06
3174 A population of descending neurons that regulate the flight motor of Drosophila
Namiki, S.; Ros, I. G.; Morrow, C.; Rowell, W. J.; Card, G. M.; Korff, W.; Dickinson, M. H.
10.1101/2021.08.05.455281 — neuroscience — Posted on 2021-08-06
3177 The Inherent Flexibility of Receptor Binding Domains in SARS-CoV-2 Spike Protein
Dokainish, H. M.; Re, S.; Mori, T.; Kobayashi, C.; Jung, J.; Sugita, Y.
10.1101/2021.08.06.455384 — biophysics — Posted on 2021-08-06
3179 Expression of soluble methane monooxygenase in Escherichia coli enables methane conversion
Bennett, R. K.; Dzvova, N.; Dillon, M.; Jones, S.; Hestmark, K.; Zhu, B.; Helman, N.; Greenfield, D.; Clarke, E.; Papoutsakis, E. T.
10.1101/2021.08.05.455234 — bioengineering — Posted on 2021-08-06
3180 Small-molecule ligands can inhibit -1 programmed ribosomal frameshifting in a broad spectrum of coronaviruses
Munshi, S.; Neupane, K.; Ileperuma, S. M.; Halma, M. T.; Kelly, J. A.; Halpern, C. F.; Dinman, J. D.; Loerch, S.; Woodside, M. T.
10.1101/2021.08.06.455424 — biochemistry — Posted on 2021-08-06
3181 GC content but not nucleosome positioning directly contributes to intron-splicing efficiency in Paramecium
Gnan, S.; Matelot, M.; Weiman, M.; Arnaiz, O.; Guerin, F.; Sperling, L.; Betermier, M.; Thermes, C.; Chen, C.-L.; Duharcourt, S.
10.1101/2021.08.05.455221 — genomics — Posted on 2021-08-06
3183 Differential use of multiple genetic sex determination systems in divergent ecomorphs of an African crater lake cichlid
Munby, H.; Linderoth, T.; Fischer, B.; Du, M.; Vernaz, G.; Tyers, A. M.; Ngatunga, B. P.; Shechonge, A.; Denise, H.; McCarthy, S. A.; Bista, I.; Miska, E. A.; Santos, M. E.; Genner, M. J.; Turner, G. F.; Durbin, R.
10.1101/2021.08.05.455235 — evolutionary biology — Posted on 2021-08-06
3185 slimr: An R package for integrating data and tailor-made population genomic simulations over space and time
Dinnage, R.; Sarre, S. D.; Duncan, R. P.; Dickman, C. R.; Edwards, S. V.; Greenville, A.; Wardle, G.; Gruber, B.
10.1101/2021.08.05.455258 — evolutionary biology — Posted on 2021-08-06
3187 Spatial organisation and homeostasis of epithelial lineages at the gastroesophageal junction is regulated by the divergent Wnt mucosal microenvironment
Kumar, N.; Gurumurthy, R. K.; Prakash, P. G.; Kurian, S. M.; Wentland, C.; Brinkmann, V.; Mollenkopf, H.-J.; Krammer, T.; Toussaint, C.; Saliba, A.-E.; Biebl, M.; Juergensen, C.; Wiedenmann, B.; Meyer, T. F.; Chumduri, C.
10.1101/2021.08.05.455222 — developmental biology — Posted on 2021-08-06
3188 Seipin forms a flexible cage at lipid droplet formation sites
Arlt, H.; Sui, X.; Folger, B.; Adams, C.; Chen, X.; Remme, R.; Hamprecht, F. A.; DiMaio, F.; Liao, M.; Goodman, J. M.; Farese, R. V.; Walther, T. C.
10.1101/2021.08.05.455270 — molecular biology — Posted on 2021-08-06
3191 SARS-CoV-2 B.1.617.2 Delta variant replication, sensitivity to neutralising antibodies and vaccine breakthrough
Mlcochova, P.; Kemp, S. A.; Shanker Dhar, M.; Papa, G.; Meng, B.; Mishra, S.; Whittaker, C.; Mellan, T.; Ferreira, I.; Datir, R.; Collier, D.; Singh, S.; Pandey, R.; Ponnusamy, K.; Radhakrishnan, V. S.; Sengupta, S.; Brown, J.; Marwal, R.; Ponnusamy, K.; Radhakrishnan, V. S.; Goonawardne, N.; Abdullahi, A.; Devi, P.; Wattal, C.; Caputo, D.; Peacock, T.; Goel, N.; Vaishya, R.; Charles, O.; Chattopadhyay, P.; Agarwal, M.; Satwik, A.; INSACOG CONSORTIUM, ; NIHR Bioresource Collaboration, ; Mavousian, A.; Brown, J.; Zhou, J.; Goonawardne, N.; Hyeon Lee, J.; Bassi, J.; Silacci-Fegni, C.; Saliba,
10.1101/2021.05.08.443253 — microbiology — Posted on 2021-08-06
3192 Shading Reduces Water Deficit in Strawberry (Fragaria x ananassa Duch.) Plants during Vegetative Growth
Cordoba-Novoa, H. A.; Perez Trujillo, M. M.; Cruz Rincon, B. E.; Florez Velazco, N.; Magnitskiy, S.; Moreno, L. P.
10.1101/2021.08.05.455240 — plant biology — Posted on 2021-08-06
3193 Integrating omics approaches to discover and prioritize candidate genes involved in oil biosynthesis in soybean
Turquetti-Moraes, D. K.; Moharana, K. C.; Almeida-Silva, F.; Pedrosa-Silva, F.; Venancio, T. M.
10.1101/2021.08.05.455283 — plant biology — Posted on 2021-08-06
3195 Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level
Leary, S.; Gaudieri, S.; Parker, M. D.; Chopra, A.; James, I.; Pakala, S.; Alves, E.; John, M.; Lindsey, B. B.; Keeley, A. J.; Rowland-Jones, S. L.; Swanson, M.; Ostrov, D. A.; Bubenik, J. L.; Das, S.; Sidney, J.; Sette, A.; COVID-19 Genomics UK (COG-UK) consortium, ; de Silva, T. I.; Phillips, E. J.; Mallal, S.
10.1101/2020.04.10.029454 — microbiology — Posted on 2021-08-06
3196 Virucidal activity of CPC-containing oral rinses against SARS-CoV-2 variants and are active in the presence of human saliva
Anderson, E. R.; Patterson, E. I.; Richards, S.; Green, A. K.; Mukherjee, S.; Hoptroff, M.; Hughes, G.
10.1101/2021.08.05.455040 — microbiology — Posted on 2021-08-06
3197 Proteomic landscape of multi-layered breast cancer internal tumor heterogeneity
Mardamshina, M.; Shenoy, A.; Necula, D.; Krol, K.; Pirak, D.; Itzhacky, N.; Marin, I.; Shalmon, B.; Sharan, R.; Gal-Yam, E. N.; Barshack, I.; Geiger, T.
10.1101/2021.08.05.455361 — cancer biology — Posted on 2021-08-06
3200 Quantitative analysis of tumour spheroid structure
Browning, A. P.; Sharp, J. A.; Murphy, R. J.; Gunasingh, G.; Lawson, B.; Burrage, K.; Haass, N. K.; Simpson, M. J.
10.1101/2021.08.05.455334 — cancer biology — Posted on 2021-08-06
3201 iRhom2 regulates ERBB signalling to promote KRAS-driven oncogenesis
Sieber, B.; Lu, F.; Stribbling, S. M.; Grieve, A. G.; Ryan, A. J.; Freeman, M.
10.1101/2021.08.06.455383 — cancer biology — Posted on 2021-08-06
3202 Developing a Novel Positronium Biomarker for Cardiac Myxoma Imaging
Moskal, P.; Kubicz, E.; Grudzien, G.; Czerwinski, E.; Dulski, K.; Leszczynski, B.; Niedzwiecki, S.; Stepien, E. L.
10.1101/2021.08.05.455285 — biophysics — Posted on 2021-08-06
3205 Heterochromatin diversity modulates genome compartmentalization and loop extrusion barriers
Spracklin, G.; Abdennur, N. A.; Imakaev, M.; Chowdhury, N.; Pradhan, S.; Mirny, L.; Dekker, J.
10.1101/2021.08.05.455340 — genomics — Posted on 2021-08-06
3206 Characterization and clustering of kinase isoform expression in metastatic melanoma
Holland, D. O.; Gotea, V.; Fedkenheuer, K.; Jaiswal, S. K.; Elnitski, L.
10.1101/2021.08.05.455315 — genomics — Posted on 2021-08-06
3208 Sift-PULs: A public repository for specific functional polysaccharide utilization loci
Song, T.; Wei, C.; Yuan, D.; Xiang, S.; Liu, L.; Lv, H.; Wang, B.; Huang, T.; Zhao, K.; Wang, X.; Chu, Y.; Lin, J.
10.1101/2021.08.04.455021 — bioinformatics — Posted on 2021-08-06
3209 Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins
Leyrat, C.; Granier, S.; Durroux, T.; Bechara, C.; Jeannot, S.; Peysson, F.; Grison, C. M.; Verdie, P.; Brunel, L.; Hoh, F.; Cong, X.; Otun, O.; Lambey, P.
10.1101/2021.08.05.455213 — biochemistry — Posted on 2021-08-06
3210 The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathione-β-synthase domain
Knejzlik, Z.; Dolezal, M.; Herkommerova, K.; Clarova, K.; Klima, M.; Dedola, M.; Zbornikova, E.; Rejman, D.; Pichova, I.
10.1101/2021.08.05.455185 — biochemistry — Posted on 2021-08-06
3213 Direct reprogramming of human fibroblasts into insulin-producing cells by transcription factors
Gasa, R.; Fontcuberta-PiSunyer, M.; Garcia-Alaman, A.; Prades, E.; Tellez, N.; Figueiredo, H.; Fernandez-Ruiz, R.; Cervantes, S.; Enrich, C.; Clua, L.; Ramon-Azcon, J.; Broca, C.; Wojtusciszyn, A.; Novials, A.; Montserrat, N.; Vidal, J.; Gomis, R.
10.1101/2021.08.05.455196 — developmental biology — Posted on 2021-08-06
3215 Global emergence and dissemination of Neisseria gonorrhoeae ST-9363 isolates with reduced susceptibility to azithromycin
Joseph, S. J.; Thomas, J. C.; Schmerer, M.; Cartee, J.; St, Cyr, S.; Schlanger, K.; Kersh, E.; Raphael, B. H.; Gernert, K.
10.1101/2021.08.05.455198 — microbiology — Posted on 2021-08-06
3218 GEPSi: A Python Library to Simulate GWAS Phenotype Data
Reidenbach, D. A.; Lal, A.; Slim, L.; Mosafi, O.; Israeli, J.
10.1101/2021.08.04.455085 — genomics — Posted on 2021-08-06
3219 Broad domains of histone marks in the highly compact Paramecium macronuclear genome
Drews, F.; Salhab, A.; Karunanithi, S.; Cheaib, M.; Jung, M.; Schulz, M.; Simon, M.
10.1101/2021.08.05.454756 — genomics — Posted on 2021-08-06
3223 Leaf area index estimation of even-aged oak (Quercus petraea) forests using in situ stand dendrometric parameters
Maxime, B.; Francois, C.; Lebourgeois, F.; Seynave, I.; Ningre, F.; Vincent, G.; Korboulewsky, N.; Perot, T.; Dufrene, E.; Perret, S.
10.1101/2021.08.05.454476 — ecology — Posted on 2021-08-06
3224 Dystrophin modulates focal adhesion tension and YAP-mediated mechanotransduction
Ramirez, M. P.; Anderson, M. J.; Sundby, L. J.; Hagerty, A. R.; Wenthe, S. J.; Ervasti, J. M.; Gordon, W. R.
10.1101/2021.08.05.455167 — cell biology — Posted on 2021-08-06
3225 Cis regulation within a cluster of viral microRNAs
Vilimova, M.; Contrant, M.; Randrianjafy, R.; Dumas, P.; Elbasani, E.; Ojala, P. M.; Pfeffer, S.; Fender, A.
10.1101/2020.11.19.389551 — molecular biology — Posted on 2021-08-06
3227 The ethanol tolerance in Saccharomyces cerevisiae under a phenomics perspective
Wolf, I. R.; Marques, L. F.; Almeida, L. F. d.; Lazari, L. C.; Moraes, L. N. d.; Cardoso, L. H.; Alves, C. C. d. O.; Nakajima, R. T.; Schnepper, A. P.; Golim, M. d. A.; Cataldi, T. R.; Nijland, J. G.; Pinto, C. M.; Fioretto, M. N.; Almeida, R. O.; Driessen, A. J. M.; Simoes, R. P.; Labate, M. V.; Grotto, R. M. T.; Labate, C. A.; Junior, A. F.; Justulin, L. A.; Coan, R. L. B.; Ramos, E.; Furtado, F. B.; Martins, C.; Valente, G. T.
10.1101/2021.08.04.455136 — systems biology — Posted on 2021-08-06
3229 Identification of an isoflavonoid transporter required for the nodule establishment of the Rhizobium-Fabaceae symbiotic interaction
Biala-Leonhard, W.; Zanin, L.; Gottardi, S.; de Brito Francisco, R.; Venuti, S.; Valentinuzzi, F.; Mimmo, T.; Cesco, S.; Bassin, B.; Martinoia, E.; Pinton, R.; Jasinski, M.; Tomasi, N.
10.1101/2021.07.30.452494 — plant biology — Posted on 2021-08-06
3230 Sex-dependent development of Kras-induced anal squamous cell carcinoma in mice
Walcheck, M.; Matkowskyj, K.; Turco, A. E.; Blaine-Sauer, S.; Nukaya, M.; Noel, J. L.; Ronnekleiv, O. K.; Ronnekleiv-Kelly, S.
10.1101/2021.08.04.455138 — cancer biology — Posted on 2021-08-06
3231 Functional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma
Choudhry, P.; Gugliemini, O.; Geng, H.; Sarin, V.; Sarah, L.; Lin, Y.-H. T.; Paranjape, N.; Ramkumar, P.; Marcoulis, M.; Wang, D.; Phojanakong, P.; Steri, V.; Hann, B.; Kampmann, M.; Wiita, A.
10.1101/2021.08.04.455165 — cancer biology — Posted on 2021-08-06
3233 Near-Zero Phase-Lag Hyperscanning in a Novel Wireless EEG System
Chuang, C.-H.; Lu, S.-W.; Chao, Y.-P.; Peng, P.-H.; Hsu, H.-C.; Jung, T.-P.
10.1101/2021.08.04.454932 — bioengineering — Posted on 2021-08-06
3235 Mites alight! Sunflower crop area and pollen supplementation enhance honey bee resistance to Varroa destructor
Palmer-Young, E. C.; Malfi, R.; Zhou, Y.; Joyce, B.; Whitehead, H.; Van Wyk, J. I.; Baylis, K.; Grubbs, K.; Lopez, D.; Evans, J. D.; Irwin, R. E.; Adler, L. S.
10.1101/2021.08.04.454914 — ecology — Posted on 2021-08-06
3238 Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival
Leduc-Gaudet, J.-P.; Miguez, K.; Cefis, M.; Moamer, A.; Chaffer, T. J.; Faitg, J.; Reynaud, O.; Broering, F. E.; Shams, A.; Mayaki, D.; Huck, L.; Sandri, M.; Gouspillou, G.; Hussain, S.
10.1101/2021.08.05.455081 — cell biology — Posted on 2021-08-06
3241 Mucin-mimetic action of capsaicin improves high fat diet-induced gut barrier dysfunction in mice colon
Kumar, V.; Kumar, V.; Mahajan, N.; Kaur, J.; Devi, K.; Dharavath, R. N.; Singh, R. P.; Kondepudi, K. K.; Bishnoi, M.
10.1101/2021.08.04.455153 — pharmacology and toxicology — Posted on 2021-08-06
3242 The synergistic effect of circRNA methylation promotes pulmonary fibrosis
Wang, S.; Luo, W.; Huang, J.; Chen, M.; Ding, J.; Cheng, Y.; Zhang, W.; Fang, S.; Wang, J.; Chao, J.
10.1101/2021.08.05.455186 — pharmacology and toxicology — Posted on 2021-08-06
3243 Pancreatic Brsk2 amplifies parasympathetic signals to promote type 2 diabetes
Xu, R.; Wang, K.; Yao, Z.; Jin, L.; Pang, J.; Zhou, Y.; Wang, K.; Liu, D.; Zhang, Y.; Sun, P.; Wang, F.; Chang, x.; Li, Y.; Wang, S.; Zhang, Y.; Lin, S.-Y.; Hu, C.; Zhu, Y.; Han, X.
10.1101/2021.08.05.455219 — pathology — Posted on 2021-08-06
3244 Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia
Wang, H.; Lu, J.; Alencastro, F.; Roberts, A.; Fiedor, J.; Carroll, P.; Eisenman, R.; Ranganathan, S.; Torbenson, M.; Duncan, A. W.; Prochownik, E. V.
10.1101/2021.08.05.455215 — cancer biology — Posted on 2021-08-06
3245 Cancer Cells Viscoelasticity Measurement by Quantitative Phase and Flow Stress Induction
Vicar, T.; Gumulec, J.; Chmelik, J.; Navratil, J.; Kolar, R.; Chmelikova, L.; Cmiel, V.; Provaznik, I.; Masarik, M.
10.1101/2021.08.05.455201 — biophysics — Posted on 2021-08-06
3247 Energetics of a protein disorder-order transition in small molecule recognition
Mendoza-Martinez, C.; Papadourakis, M.; llabres, s.; Gupta, A. A.; Barlow, P. N.; Michel, J.
10.1101/2021.08.05.454052 — biophysics — Posted on 2021-08-06
3250 VistoSeg: a MATLAB pipeline to process, analyze and visualize high resolution histology images for Visium spatial transcriptomics data
Tippani, M.; Divecha, H. R.; Catallini, J. L.; Weber, L. M.; Spangler, A.; Jaffe, A. E.; Hicks, S. C.; Martinowich, K.; Collado-Torres, L.; Page, S. C.; Maynard, K. R.
10.1101/2021.08.04.452489 — bioinformatics — Posted on 2021-08-06
3251 A comparison of data integration methods for single-cell RNA sequencing of cancer samples
Richards, L. M.; Riverin, M.; Mohanraj, S.; Ayyadhury, S.; Croucher, D. C.; Diaz-Mejia, J. J.; Coutinho, F. J.; Dirks, P. B.; Pugh, T. J.
10.1101/2021.08.04.453579 — bioinformatics — Posted on 2021-08-06
3254 Transient late gestation prenatal hypoxic insult results in functional deficits but not gross neuroanatomic deficits in mice
Cristancho, A. G.; Gadra, E. C.; Samba, I. M.; Zhao, C.; Ouyang, M.; Magnitsky, S.; Huang, H.; Viaene, A. N.; Anderson, S. A.; Marsh, E. D.
10.1101/2021.08.04.451528 — animal behavior and cognition — Posted on 2021-08-06
3255 The lesser Pacific striped octopus, Octopus chierchiae: an emerging laboratory model for the study of octopuses
Grearson, A. G.; Dugan, A.; Sakmar, T.; Dolen, G.; Gire, D. H.; Sivitilli, D. M.; Niell, C.; Caldwell, R. L.; Wang, Z. Y.; Grasse, B.
10.1101/2021.08.04.455148 — animal behavior and cognition — Posted on 2021-08-06
3256 The genetic etiology of longitudinal measures of predicted brain ageing in a population-based sample of mid to late-age males
Gillespie, N. A.; Hatton, S. N.; Hagler, D. H.; Dale, A. M.; Elman, J. A.; McEvoy, L. K.; Elyer, L. T.; Fennema-Notestine, C.; Logue, M. W.; McKenzie, R. E.; Puckett, O. K.; Tu, X. M.; Whitsel, N.; Xian, H.; Reynolds, C. A.; Panizzon, M. S.; Lyons, M. J.; Neale, M. C.; Kremen, W. S.; Franz, C.
10.1101/2021.08.04.455143 — genetics — Posted on 2021-08-06
3257 Multivariate Genomewide Association Analysis with IHT
Chu, B. B.; Ko, S.; Zhou, J. J.; Zhou, H.; Sinsheimer, J. S.; Lange, K. L.
10.1101/2021.08.04.455145 — genetics — Posted on 2021-08-06
3261 Evolution of a costly immunity to cestode parasites is a pyrrhic victory
Weber, J. N.; Steinel, N. C.; Peng, F.; Shim, K. C.; Lohman, B. K.; Fuess, L.; De Lisle, S.; Bolnick, D. I.
10.1101/2021.08.04.455160 — evolutionary biology — Posted on 2021-08-06
3262 Molecular Evolution across Mouse Spermatogenesis
Kopania, E. E. K.; Larson, E. L.; Callahan, C.; Keeble, S.; Good, J. M.
10.1101/2021.08.04.455131 — evolutionary biology — Posted on 2021-08-06
3263 Protist.guru: a comparative transcriptomics database for the protist kingdom
Villanueva, E. M. F.; Lim, P. K.; Lim, J. J. J.; Lim, S. C.; Lau, P. Y.; Koh, K. T. S.; Tan, E.; Kairon, R. S.; See, W. A.; Liao, J. X.; Hee, K. M.; Vijay, V.; Maitra, I.; Boon, C. J.; Fo, K.; Wang, Y. T.; Jaya, R.; Hew, L. A.; Lim, Y. Y.; Lee, W. Q.; Lee, Z. Q.; Foo, H.; Lopes dos Santos, A.; Mutwil, M.
10.1101/2021.08.04.455173 — evolutionary biology — Posted on 2021-08-06
3264 Does the rainbow trout ovarian fluid guide the spermatozoon on its way to the egg?
Kholodnyy, V.; Dzyuba, B.; Rodina, M.; Bloomfield-Gadelha, H.; Yoshida, M.; Cosson, J.; Boryshpolets, S.
10.1101/2021.08.05.453951 — ecology — Posted on 2021-08-06
3265 rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin
Yu, H.; Sun, Z.; Tan, T.; Pan, H.; Zhao, J.; Zhang, L.; Chen, J.; Lei, A.; Zhu, Y.; Chen, L.; Xu, Y.; Chen, M.; Gao, S.; Daley, G. Q.; Zhang, J.
10.1101/2021.08.04.454705 — cell biology — Posted on 2021-08-06
3266 Sterol scarcity primes p38 immune defenses through a TIR-1/SARM1 phase transition
Peterson, N. D.; Icso, J. D.; Salisbury, J. E.; Rodriguez, T. C.; Thompson, P.; Pukkila-Worley, R.
10.1101/2021.08.05.455128 — immunology — Posted on 2021-08-06
3267 Cellular heterogeneity and molecular reprogramming of host response during influenza acute lung injury
Guo, K.; Yombo, D. J. K.; Schmit, T.; Wang, Z.; Ghosh, S.; Sathish, V.; Mathur, R.; Wu, M.; Hur, J.; Khan, M. N.
10.1101/2021.08.05.455152 — immunology — Posted on 2021-08-06
3271 Embedded 3D printing in self-healing annealable composites for functional patterning of human neural constructs
Kajtez, J.; Wessler, M. F.; Birtele, M.; Khorasgani, F. R.; Ottosson, D. R.; Heiskanen, A.; Kamperman, T.; Leijten, J.; Martinez-Serrano, A.; Larsen, N. B.; Angelini, T. E.; Parmar, M.; Lind, J. U.; Emneus, J.
10.1101/2021.08.04.455135 — bioengineering — Posted on 2021-08-06
3272 Dietary habits of free-ranging banded langur (Presbytis femoralis) in a secondary-human modified forest in Johor, Malaysia
Najmuddin, M. F.; Haris, H.; Norazlimi, N.; Ruslin, F.; Matsuda, I.; Md-Zain, B. M.; Abdul-Latiff, M. A. B.
10.1101/2021.03.16.435588 — ecology — Posted on 2021-08-06
3273 Testing for pollinator recognition in multiple species of Heliconia
Gannon, D. G.; Hadley, A. S.; Kormann, U. G.; Jones, F. A.; Betts, M. G.
10.1101/2021.04.08.438933 — ecology — Posted on 2021-08-06
3277 The pink salmon genome: uncovering the genomic consequences of a strict two-year life-cycle
Christensen, K. A.; Rondeau, E. B.; Sakhrani, D.; Biagi, C. A.; Johnson, H.; Joshi, J.; Flores, A.-M.; Leelakumari, S.; Moore, R.; Pandoh, P. K.; Withler, R. E.; Beacham, T. D.; Leggatt, R. A.; Tarpey, C. M.; Seeb, L. W.; Seeb, J. E.; Jones, S. J. M.; Devlin, R. H.; Koop, B. F.
10.1101/2021.08.05.455323 — genomics — Posted on 2021-08-06
3278 Determining the stability of genome-wide factors in BMI between ages 40 to 69 years.
Gillespie, N. A.; Gentry, A. E.; Kirkpatrick, R. M.; Maes, H. H.; Reynolds, C. A.; Mathur, R.; Kendler, K. S.; Peterson, R. E.; Webb, B. T.
10.1101/2021.07.28.454172 — genetics — Posted on 2021-08-05
3283 Brain Laterality Dynamics Support Human Cognition
Wu, X.; Kong, X.-Z.; Vatansever, D.; Liu, Z.; Zhang, K.; Barbara J Sahakian, B.; Robbins, T.; Feng, J.; Thompson, P.; Zhang, J.
10.1101/2021.08.05.455350 — neuroscience — Posted on 2021-08-05
3284 KIF2C regulates synaptic plasticity and cognition by mediating dynamic microtubule invasion of dendritic spines
Zheng, R.; Du, Y.; Wang, X.; Liao, T.; Zhang, Z.; Wang, N.; Li, X.; Shen, Y.; Shi, L.; Luo, J.; Xia, J.; Wang, Z.; Xu, J.
10.1101/2021.08.05.455197 — neuroscience — Posted on 2021-08-05
3285 The road not taken: disconnection of a human-unique cortical pathway in schizophrenia and its effects on naturalistic social cognition
Patel, G. H.; Gruskin, D. C.; Arkin, S. C.; Jamerson, E. C.; Ruiz-Betancourt, D. R.; Klim, C. C.; Sanchez-Pena, J. P.; Bartel, L. P.; Lee, J. K.; Grinband, J.; Martinez, A.; Berman, R. A.; Ochsner, K. N.; Leopold, D. A.; Javitt, D. C.
10.1101/2021.08.04.455137 — neuroscience — Posted on 2021-08-05
3287 Association of stress-related limbic activity and baseline interleukin-6 plasma levels in healthy adults
Voges, J. F.; Mueller-Pinzler, L.; Neis, M.; Luebber, F.; Lange, T.; Hundt, J. E.; Kasten, M.; Kraemer, U. M.; Krach, S.; Rademacher, L.
10.1101/2021.03.26.437134 — neuroscience — Posted on 2021-08-06
3290 Constructing a warhead of PROTAC with aptamer for tumor-selective degradation of nucleolin
Zhang, L.; Li, L.; Wang, X.; Dai, J.; Zhou, L.; Zhang, Y.; Xie, T.; Zhang, H.; Peng, T.; Sun, X.; Li, H.; Liu, J.; Wu, W.; Ye, M.; Tan, W.
10.1101/2021.08.05.455211 — biochemistry — Posted on 2021-08-05
3293 Evolution of a minimal cell
Moger-Reischer, R. Z.; Glass, J. I.; Wise, K.; Bittencourt, D.; Sun, L.; Lynch, M.; Lennon, J. T.
10.1101/2021.06.30.450565 — evolutionary biology — Posted on 2021-08-05
3299 Nuclear Lamina binds the EBV genome during latency and regulates viral gene expression
Caruso, L. B.; Guo, R.; Boyle, S.; Keith, K.; Madzo, J.; Wasserman, J.; Kossenkov, A.; Gewurz, B.; Tempera, I.
10.1101/2021.08.05.455214 — microbiology — Posted on 2021-08-05
3301 Th1/17 Cells Infiltrate Murine Cytomegalovirus-Infected Renal Allografts via Virus-Induced CCL20 and Promote Th1 Cells through IL-17A.
Dhital, R.; Anand, S.; Zeng, Q.; Velazquez, V. M.; Boddeda, S. R.; Fitch, J.; Minz, R. W.; Minz, M.; Sharma, A.; Cianciolo, R.; Shimamura, M.
10.1101/2021.08.05.455061 — immunology — Posted on 2021-08-05
3302 Vaccination with B.1.1.7, B.1.351 and P.1 variants protects mice from challenge with wild type SARS-CoV-2
Amanat, F.; Strohmeier, S.; Meade, P.; Dambrauskas, N.; Mühlemann, B.; Smith, D. J.; Vigdorovich, V.; Sather, D. N.; Coughlan, L.; Krammer, F.
10.1101/2021.08.05.455212 — immunology — Posted on 2021-08-05
3303 Harmonisation of multi-site MRS data with ComBat
Bell, T. K.; Godfrey, K. J.; Ware, A. L.; Yeates, K. O.; Harris, A. D.
10.1101/2021.08.04.455132 — neuroscience — Posted on 2021-08-05
3307 Outer Hair Cell Function is Normal in βV Spectrin Knockout Mice
Stankewich, M. C.; Bai, J.-P.; Stabach, P. R.; Khan, S.; Tan, W. J. T.; Surguchev, A.; Song, L.; Morrow, J. S.; Santos-Sacchi, J.; Navaratnam, D. S.
10.1101/2021.02.01.427491 — neuroscience — Posted on 2021-08-05
3309 Delta- and theta-band cortical tracking and phase-amplitude coupling to sung speech by infants
Attaheri, A.; Ni Choisdealbha, A.; Di Liberto, G.; Rocha, S.; Brusini, P.; Mead, N.; Olawole-Scott, H.; Boutris, P.; Gibbon, S.; Williams, I.; Grey, C.; Flanagan, S.; Goswami, U.
10.1101/2020.10.12.329326 — neuroscience — Posted on 2021-08-05
3314 Correlational networking guides the discovery of cryptic natural product biosynthetic enzymes
Xue, D.; Older, E. A.; Zhong, Z.; Shang, Z.; Chen, N.; Dittenhauser, N.; Hou, L.; Walla, M. D.; Dong, S.-H.; Tang, X.; Nagarkatti, P.; Nagarkatti, M.; Li, Y.-X.; Li, J.
10.1101/2021.07.26.453782 — biochemistry — Posted on 2021-08-05
3316 Rapid specialization of counter defenses enables two-spotted spider mite to adapt to novel plant hosts
Salehipourshirazi, G.; Bruinsma, K.; Ratlamwala, H.; Dixit, S.; Arbona, V.; Widemann, E.; Milojevic, M.; Jin, P.; Bensoussan, N.; Gomez-Cadenas, A.; Zhurov, V.; Grbic, M.; Grbic, V.
10.1101/2020.02.26.966481 — evolutionary biology — Posted on 2021-08-05
3320 Limited variation between SARS-CoV-2-infected individuals in domain specificity and relative potency of the antibody response against the spike glycoprotein
Van Ert, H. A.; Bohan, D. W.; Rogers, K. J.; Fili, M.; Rojas Chavez, A. R.; Qing, E.; Han, C.; Dempewolf, S. M.; Hu, G.; Schwery, N.; Sevcik, K. M.; Ruggio, N.; Boyt, D.; Pentella, M.; Gallagher, T.; Jackson, J. B.; Merrill, A. E.; Knudson, C. M.; Brown, G.; Maury, W.; Haim, H.
10.1101/2021.08.04.455181 — microbiology — Posted on 2021-08-05
3321 EEG and behavioral correlates of attentional processing while walking and navigating naturalistic environments
Liebherr, M.; Corcoran, A. W.; Alday, P. M.; Coussens, S.; Bellan, V.; Howlett, C. A.; Immink, M. A.; Kohler, M.; Schlesewsky, M.; Bornkessel-Schlesewsky, I.
10.1101/2021.05.27.445993 — neuroscience — Posted on 2021-08-05
3325 Ribosome elongation kinetics of consecutively charged residues are coupled to electrostatic force
Leininger, S. E.; Rodriguez, J.; Vu, Q. V.; Jiang, Y.; Li, M. S.; Deutsch, C.; O'Brien, E. P.
10.1101/2021.08.04.455055 — biophysics — Posted on 2021-08-05
3327 Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms
Pividori, M.; Lu, S.; Li, B.; Su, C.; Johnson, M. E.; Wei, W.-Q.; Feng, Q.; Namjou, B.; Kiryluk, K.; Kullo, I.; Luo, Y.; Sullivan, B. D.; Voight, B. F.; Skarke, C.; Ritchie, M. D.; Grant, S. F. A.; Greene, C. S.
10.1101/2021.07.05.450786 — bioinformatics — Posted on 2021-08-05
3331 Mechanism of Tethered Agonist-Mediated Signaling by Polycystin-1
Pawnikar, S.; Magenheimer, B. S.; Nevarez-Munoz, E.; Maser, R. L.; Miao, Y.
10.1101/2021.08.05.455255 — biochemistry — Posted on 2021-08-05
3332 Mechanism of Tripeptide Trimming by γ-Secretase
Bhattarai, A.; Devkota, S.; Do, H. N.; Wang, J.; Bhattarai, S.; Wolfe, M. S.; Miao, Y.
10.1101/2021.08.05.455243 — biochemistry — Posted on 2021-08-05
3333 Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity
Vohnoutka, R. B.; Kuppa, A.; Hegde, Y.; Chen, Y.; Pant, A.; Choi, E.-Y. K.; McCarty, S. M.; Bagchi, D.; Du, X.; Chen, Y.; Chen, V. L.; Bielak, L. F.; Maguire, L. H.; Handelman, S. K.; Sexton, J. Z.; Saunders, T.; Halligan, B. D.; Speliotes, E. K.
10.1101/2021.08.05.455257 — biochemistry — Posted on 2021-08-05
3335 Evolution-Inspired Engineering of Anthracycline Methyltransferases
Dinis, P.; Tirkkonen, H.; Siitonen, V.; Nji Wandi, B.; Niemi, J.; Grocholski, T.; Metsa-Ketela, M.
10.1101/2021.08.05.455194 — biochemistry — Posted on 2021-08-05
3338 σ28-dependent small RNAs regulate timing of flagella biosynthesis
Melamed, S.; Zhang, A.; Jarnik, M.; Mills, J.; Zhang, H.; Storz, G.
10.1101/2021.08.05.455139 — microbiology — Posted on 2021-08-05
3339 One Health or Three? Transmission modelling of Klebsiella isolates reveals ecological barriers to transmission between humans, animals and the environment
Thorpe, H. A.; Booton, R.; Kallonen, T.; Gibbon, M. J.; Couto, N.; Passet, V. A.; Fernandez, J.; Rodrigues, C.; Matthews, L.; Mitchell, S.; Reeve, R.; David, S.; Merla, C.; Corbella, M.; Ferrari, C.; Comandatore, F.; Marone, P.; Brisse, S.; Sassera, D.; Corander, J.; Feil, E. J.
10.1101/2021.08.05.455249 — microbiology — Posted on 2021-08-05
3340 Interbacterial transfer of carbapenem resistance and large antibiotic resistance islands by natural transformation in pathogenic Acinetobacter
Godeux, A.-S.; Svedholm, E.; Barreto, S.; Lupo, A.; Haenni, M.; Potron, A.; Venner, S.; Charpentier, X.; Laaberki, M.-H.
10.1101/2021.08.05.455225 — microbiology — Posted on 2021-08-05
3342 Canine oral melanoma genomic and transcriptomic study defines two molecular subgroups with different therapeutical targets
Prouteau, A.; Mottier, S.; Primot, A.; Cadieu, E.; Bachelot, L.; Botherel, N.; Cabilic, F.; Houel, A.; Cornevin, L.; Kergal, C.; Corre, S.; Abadie, J.; Hitte, C.; Gilot, D.; Lindblad-Toh, K.; Andre, C.; Derrien, T.; Hedan, B.
10.1101/2021.08.04.455031 — cancer biology — Posted on 2021-08-05
3346 Optical nanoscopy reveals SARS-CoV-2-induced remodeling of human airway cells
Nijenhuis, W.; Damstra, H. G. J.; van Grinsven, E. J.; Iwanski, M. K.; Praest, P.; Soltani, Z. E.; van Grinsven, M. M. P.; Brunsveld, J. E.; De Kort, T. M.; Rodenburg, L. W.; de Jong, D. C. M.; Raeven, H. M.; Spelier, S.; Amatngalim, G. D.; Akhmanova, A.; Nijhuis, M.; Lebbink, R. J.; Beekman, J. M.; Kapitein, L. C. M.
10.1101/2021.08.05.455126 — cell biology — Posted on 2021-08-05
3347 Metabolic reprogramming of cytotoxic T lymphocytes by high glucose enhances pancreatic beta cell apoptosis via TRAIL
Yang, W.; Denger, A.; Diener, C.; Kueppers, F.; Soriano-Baguet, L.; Schaefer, G.; Yanamandra, A. K.; Zhao, R.; Knoerck, A.; Schwarz, E. C.; Hart, M.; Lammert, F.; Roma, L. P.; Brenner, D.; Grigorios Christidis, G.; Helms, V.; Meese, E.; Hoth, M.; Qu, B.
10.1101/2021.08.04.455060 — immunology — Posted on 2021-08-05
3354 Pandemic-Scale Phylogenomics Reveals Elevated Recombination Rates in the SARS-CoV-2 Spike Region
Turakhia, Y.; Thornlow, B.; Hinrichs, A. S.; Mcbroome, J.; Ayala, N.; Ye, C.; De Maio, N.; Haussler, D.; Lanfear, R.; Corbett-Detig, R.
10.1101/2021.08.04.455157 — evolutionary biology — Posted on 2021-08-05
3357 Virucidal activity of CPC-containing oral rinses against SARS-CoV-2 variants and are active in the presence of human saliva
Anderson, E. R.; Patterson, E. I.; Richards, S.; Green, A. K.; Mukherjee, S.; Hoptroff, M.; Hughes, G.
10.1101/2021.08.05.455040 — microbiology — Posted on 2021-08-05
3358 Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles
Syed, A. M.; Taha, T. Y.; Khalid, M. M.; Tabata, T.; Chen, I. P.; Sreekumar, B.; Chen, P.-Y.; Hayashi, J. M.; Soczek, K. M.; Ott, M.; Doudna, J. A.
10.1101/2021.08.05.455082 — microbiology — Posted on 2021-08-05
3359 Identification of Potent Small Molecule Inhibitors of SARS-CoV-2 Entry
Jablonski, S.; Mou, H.; Otsuka, Y.; Jablonski, J.; Adcock, R. S.; Batra, L.; Chung, D.; Rood, C.; de Vera, I. M.; Rahaim, R.; Ullah, S.; Yu, X.; Nguyen, T.-T.; Hull, M. V.; Chen, E.; Bannister, T.; Baillargeon, P.; Scampavia, L.; Farzan, M.; Valente, S.; Spicer, T.
10.1101/2021.08.05.455262 — microbiology — Posted on 2021-08-05
3360 SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage
Escalera, A.; Gonzalez-Reiche, A. S.; Aslam, S.; Mena, I.; Pearl, R. L.; Laporte, M.; Fossati, A.; Rathnasinghe, R.; Alshammary, H.; van de Guchte, A.; Bouhaddou, M.; Kehrer, T.; Zuliani-Alvarez, L.; Meekins, D. A.; Balaraman, V.; McDowell, C.; Richt, J. A.; Bajic, G.; Sordillo, E. M.; Krogan, N.; Simon, V.; Albrecht, R. A.; van Bakel, H.; Garcia-Sastre, A.; Aydillo, T.
10.1101/2021.08.05.455290 — microbiology — Posted on 2021-08-05
3362 Natural Killer cell division regulates FcεRIγ expression downstream of mTOR activity
Shemesh, A.; Calabrese, D. R.; Arakawa-Hoyt, J.; Greenland, J. R.; Lanier, L. L.
10.1101/2021.08.03.454985 — immunology — Posted on 2021-08-05
3363 Highly accurate local functional fingerprints and their stability
Larabi, D. I.; Gell, M.; Amico, E.; Eickhoff, S. B.; Patil, K. R.
10.1101/2021.08.03.454862 — neuroscience — Posted on 2021-08-05
3366 Novel design of imputation-enabled SNP arrays for breeding and research applications supporting multi-species hybridisation
Keeble-Gagnere, G.; Pasam, R.; Forrest, K. L.; Wong, D.; Robinson, H.; Godoy, J.; Rattey, A.; Moody, D.; Mullan, D.; Walmsley, T.; Daetwyler, H. D.; Tibbits, J.; Hayden, M. J.
10.1101/2021.08.03.454059 — genetics — Posted on 2021-08-05
3367 Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits.
Rowland, B.; Venkatesh, S.; Tardaguila, M.; Wen, J.; Rosen, J. D.; Tapia, A. L.; Sun, Q.; Graff, M.; Vuckovic, D.; Lettre, G.; Sankaran, V. G.; Reiner, A. P.; Soranzo, N.; Huffman, J. E.; Voloudakis, G.; Roussos, P.; Raffield, L.; Li, Y.
10.1101/2021.08.03.453690 — genetics — Posted on 2021-08-05
3370 Immunolocalization studies of vimentin and ACE2 on the surface of cells exposed to SARS-CoV-2 Spike proteins
Lalioti, V.; Gonzalez-Sanz, S.; Lois-Bermejo, I.; Gonzalez-Jimenez, P.; Viedma-Poyatos, A.; Merino, A.; Pajares, M. A.; Perez-Sala, D.
10.1101/2021.05.04.442648 — cell biology — Posted on 2021-08-05
3371 SARS-CoV-2 fears green: the chlorophyll catabolite Pheophorbide a is a potent antiviral
Jimenez-Aleman, G. H.; Castro, V.; Longdaitsbehere, A.; Gutierrez-Rodriguez, M.; Garaigorta, U.; Gastaminza, P.; Solano, R.
10.1101/2021.07.31.454592 — molecular biology — Posted on 2021-08-05
3372 The CD8+ T cell landscape of human brain metastases
Sudmeier, L. J.; Hoang, K. B.; Nduom, E. K.; Wieland, A.; Neill, S. G.; Schniederjan, M. J.; Ramalingam, S. S.; Olson, J. J.; Ahmed, R.; Hudson, W. H.
10.1101/2021.08.03.455000 — immunology — Posted on 2021-08-05
3374 Effect of SARS-CoV-2 spike mutations on animal ACE2 usage and in vitro neutralization sensitivity
Yao, W.; Ma, D.; Wang, H.; Tang, X.; Du, C.; Pan, H.; Li, C.; Lin, H.; Farzan, M.; Zhao, J.; Li, Y.; Zhong, G.
10.1101/2021.01.27.428353 — microbiology — Posted on 2021-08-05
3375 Optimizing predictive models to prioritize viral discovery in zoonotic reservoirs
Becker, D.; Albery, G. F.; Sjodin, A. R.; Poisot, T.; Bergner, L.; Dallas, T.; Eskew, E. A.; Farrell, M. J.; Guth, S.; Han, B. A.; Simmons, N. B.; Stock, M.; Teeling, E. C.; Carlson, C. J.
10.1101/2020.05.22.111344 — ecology — Posted on 2021-08-05
3376 An efficient miRNA knockout approach using CRISPR-Cas9 in Xenopus
Godden, A. M.; Ward, N. J.; Lee, M. v. d.; Abu-Daya, A.; Guille, M.; Wheeler, G. N.
10.1101/2021.08.05.454468 — developmental biology — Posted on 2021-08-05
3378 The role of Musashi-1 in CEP290 c.2991+1655A>G cryptic exon splicing in Leber Congenital Amaurosis
Ottaviani, D.; Lane, A.; Jovanovic, K.; Gardner, J. C.; Sladen, P. E.; Hau, K. L.; Brugulat Panes, A.; Guarascio, R.; Hardcastle, A. J.; Cheetham, M. E.
10.1101/2021.08.04.454918 — cell biology — Posted on 2021-08-05
3382 A toolbox for studying cortical physiology in primates
Khateeb, K.; Bloch, J.; Zhou, J.; Rahimi, M.; Griggs, D. J.; Kharazia, V. N.; Le, M. N.; Wang, R. K.; Yazdan-Shahmorad, A.
10.1101/2021.08.04.455066 — neuroscience — Posted on 2021-08-05
3383 Biophysical network models of phase-synchronization in MEG resting-state
Williams, N.; Toselli, B.; Siebenhuhner, F.; Palva, S.; Arnulfo, G.; Kaski, S.; Palva, J. M.
10.1101/2021.08.04.455014 — neuroscience — Posted on 2021-08-05
3384 Chronic behavioral manipulation via orally delivered chemogenetic actuator in macaques
Oyama, K.; Hori, Y.; Nagai, Y.; Miyakawa, N.; Mimura, K.; Hirabayashi, T.; Inoue, K.-i.; Takada, M.; Higuchi, M.; Minamimoto, T.
10.1101/2021.08.03.454990 — neuroscience — Posted on 2021-08-05
3388 AATF/Che-1, a new component of paraspeckles, controls R-loops formation and Interferon activation in Multiple Myeloma.
Bruno, T.; Corleone, G.; Cortile, C.; de Nicola, F.; Catena, V.; Fabbretti, F.; Gumenyuk, S.; Pisani, F.; Mengarelli, A.; Passananti, C.; Fanciulli, M.
10.1101/2021.08.04.455054 — cell biology — Posted on 2021-08-05
3389 Local regulation of extracellular vesicle traffic by the synaptic endocytic machinery
Blanchette, C. R.; Scalera, A. L.; Harris, K. P.; Zhao, Z.; Koles, K.; Yeh, A.; Apiki, J. K.; Stewart, B. A.; Rodal, A. A.
10.1101/2021.08.04.454987 — cell biology — Posted on 2021-08-05
3390 Specific telomere protection ensured by FOXO3a upon genotoxic stress and during aging
Jacome Burbano, M. S.; Robin, J.; Bauwens, S.; Martin, M.; Donati, E.; Martinez, L.; Sacconi, S.; Magdinier, F.; Gilson, E.
10.1101/2021.08.04.454762 — cell biology — Posted on 2021-08-05
3392 Single particle cryo-EM structure of the outer hair cell motor protein prestin
BUtan, C.; Song, Q.; Bai, J.-p.; Tan, W.; Navaratnam, D. S.; Santos-Sacchi, J.
10.1101/2021.08.03.454998 — neuroscience — Posted on 2021-08-05
3393 Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease
Iovino, L.; Giusti, V.; Pischedda, F.; Giusto, E.; Plotegher, N.; Marte, A.; Battisti, I.; Di Iacovo, A.; Marku, A.; Piccoli, G.; Bandopadhyay, R.; Perego, C.; Bonifacino, T.; Bonanno, G.; Roseti, C.; Bossi, E.; Arrigoni, G.; Bubacco, L.; Greggio, E.; Hilfiker, S.; Civiero, L.
10.1101/2021.08.04.455053 — neuroscience — Posted on 2021-08-05
3396 Petascale neural circuit reconstruction: automated methods
Macrina, T.; Lee, K.; Lu, R.; Turner, N. L.; Wu, J.; Popovych, S.; Silversmith, W. W.; Kemnitz, N.; Bae, J. A.; Castro, M. A.; Dorkenwald, S.; Halageri, A.; Jia, Z.; Jordan, C.; Li, K.; Mitchell, E.; Mondal, S. S.; Mu, S.; Nehoran, B.; Wong, W.; Yu, S.-c.; Bodor, A. L.; Brittain, D.; Buchanan, J.; Bumbarger, D. J.; Cobos, E.; Collman, F.; Elabbady, L.; Fahey, P. G.; Froudarakis, E.; Kapner, D.; Kinn, S.; Mahalingam, G.; Papadopoulos, S.; Patel, S.; Schneider-Mizell, C. M.; Sinz, F. H.; Takeno, M.; Torres, R.; Yin, W.; Pitkow, X.; Reimer, J.; Tolias, A. S.; Reid, R. C.; Macarico da Costa, N.; S
10.1101/2021.08.04.455162 — neuroscience — Posted on 2021-08-05
3399 Harmonisation of multi-site MRS data with ComBat
Bell, T. K.; Godfrey, K. J.; Ware, A. L.; Yeates, K. O.; Harris, A. D.
10.1101/2021.08.04.455132 — neuroscience — Posted on 2021-08-05
3402 An open MRI dataset for multiscale neuroscience
Royer, J.; Rodriguez-Cruces, R.; Tavakol, S.; Lariviere, S.; Herholz, P.; Li, Q.; Vos de Wael, R.; Paquola, C.; Benkarim, O.; Park, B.-y.; Lowe, A. J.; Margulies, D. S.; Smallwood, J.; Bernasconi, A.; Bernasconi, N.; Frauscher, B.; Bernhardt, B. C.
10.1101/2021.08.04.454795 — neuroscience — Posted on 2021-08-05
3405 A pathogenic DYT-THAP1 dystonia mutation causes hypomyelination and loss of YY1 binding
Yellajoshyula, D.; Rogers, A. E.; Kim, A. J.; Kim, S.; Pappas, S. S.; Dauer, W. T.
10.1101/2021.08.03.454996 — neuroscience — Posted on 2021-08-05
3406 CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes
Djekidel, M. N.; Rosikiewicz, W.; Peng, J. C.; Kanneganti, T.-D.; Hui, Y.; Jin, H.; Hedges, D.; Schreiner, P.; Fan, Y.; Wu, G.; Xu, B.
10.1101/2021.05.14.444026 — bioinformatics — Posted on 2021-08-05
3407 A Calcium/Palmitoylation Switch Interfaces the Signaling Networks of Stress Response and Transition to Flowering
Park, H. J.; Gamez-Arjona, F.; Lindahl, M.; Aman, R.; Villalta, I.; Carranco, R.; Lim, C. J.; Garcia, E.; Bressan, R. A.; Lee, S. Y.; Sanchez-Rodriguez, C.; Pardo, J. M.; Kim, W.-Y.; Quintero, F. J.; Yun, D.-J.
10.1101/2021.08.05.455199 — plant biology — Posted on 2021-08-05
3408 The complex genetics of symbiotic extended phenotypes across environments in a model mutualism
Batstone, R. T.; Lindgren, H. K.; Allsup, C. M.; Goralka, L. A.; Riley, A. B.; Grillo, M. A.; Marshall-Colon, A.; Heath, K.
10.1101/2021.08.03.454976 — evolutionary biology — Posted on 2021-08-05
3409 Cytoplasmic labile iron accumulates in aging stem cells perturbing a key rheostat for identity control
Kao, Y.-R.; Chen, J.; Kumari, R.; Tatiparthy, M.; Ma, Y.; Aivalioti, M.; Zintiridou, A.; Thiruthuvanathan, V.; Reisz, J.; Stransky, S.; Sidoli, S.; Steidl, U.; D'Alessandro, A.; Will, B.
10.1101/2021.08.03.454947 — cell biology — Posted on 2021-08-05
3414 Identifying genomic regions and candidate genes selected during the breeding of rice in Vietnam
Higgins, J.; Santos, B.; Khanh, T. D.; Trung, K. H.; Duong, T. D.; Doai, N. T. P.; Hall, A.; Dyer, S.; Ham, L. H.; Caccamo, M.; De Vega, J. J.
10.1101/2021.08.04.455072 — plant biology — Posted on 2021-08-05
3415 Principles of sensor-effector organization in six-transmembrane ion channels
Dou, A. K.; Kang, P. W.; Hou, P.; Zaydman, M. A.; Zheng, J.; Jegla, T.; Cui, J.
10.1101/2021.08.03.454958 — biophysics — Posted on 2021-08-05
3417 De novo evolution of macroscopic multicellularity
Bozdag, G. O.; Zamani-Dahaj, S. A.; Kahn, P. C.; Day, T. C.; Tong, K.; Balwani, A. H.; Dyer, E. L.; Yunker, P. J.; Ratcliff, W. C.
10.1101/2021.08.03.454982 — evolutionary biology — Posted on 2021-08-05
3418 Influence of internal seiche dynamics on vertical movement of fish
Jaric, I.; Riha, M.; Souza, A. T.; Rabaneda-Bueno, R.; Ded, V.; Gjelland, K.; Baktoft, H.; Cech, M.; Blabolil, P.; Holubova, M.; Juza, T.; Muska, M.; Sajdlova, Z.; Smejkal, M.; Vejrik, L.; Vejrikova, I.; Peterka, J.
10.1101/2021.08.03.454964 — ecology — Posted on 2021-08-05
3424 The biosynthetic pathway of ubiquinone contributes to pathogenicity of Francisella
Kazemzadeh, K.; Hajj Chehade, M.; Gautier, H.; Camille, B.; Caspar, Y.; Loiseau, L.; Barras, F.; Pierrel, F.; Pelosi, L.
10.1101/2021.08.03.455006 — microbiology — Posted on 2021-08-05
3427 Catalase protects against non-enzymatic decarboxylations during photorespiration
Bao, H.; Morency, M.; Rianti, W.; Saeheng, S.; Roje, S.; Weber, A. P. M.; Walker, B. J.
10.1101/2021.08.04.455084 — plant biology — Posted on 2021-08-05
3429 The heterogeneity of the DNA damage response landscape determines patient outcomes in ovarian cancer
Walker, T.; Faraahi, Z.; price, m.; Hawarden, A.; Waddell, C.; Russell, B.; Jones, D.; McCormick, A.; Gavrielides, N.; Tyagi, S.; Woodhouse, L.; Whalley, B.; Roberts, C.; Crosbie, E.; Edmondson, R.
10.1101/2021.08.03.454868 — cell biology — Posted on 2021-08-05
3431 Genomic miscellany and allelic frequencies of Plasmodium falciparum msp-1, msp-2 and glurp in parasite isolates
Ullah, I.; Afridi, S. G.; Israr, M.; Khan, A.; Ali, A.; Jabeen, H.; Raasool, A.; Akbar, F.; Shah, M.
10.1101/2021.06.25.449861 — zoology — Posted on 2021-08-05
3432 Sex Identification in Cattle, based on Amelogenin Gene
Ahmad, A.; Israr, M.; Rahat, M. A.; Wahab, A.; Uddin, S.; Rasool, A.; Akbar, F.; Shah, M.
10.1101/2021.07.11.451984 — zoology — Posted on 2021-08-05
3434 High expression of VRT2 during wheat spikelet initiation increases the number of rudimentary basal spikelets
Backhaus, A. E.; Lister, A.; Tomkins, M.; Adamski, N. M.; Simmonds, J.; Macaulay, I. C.; Morris, R. J.; Haerty, W.; Uauy, C.
10.1101/2021.08.03.454952 — plant biology — Posted on 2021-08-05
3440 Identification and characterisation of splicing regulators in Toxoplasma gondii
Lee, V. V.; Seizova, S.; McMillan, P.; McHugh, E.; Tonkin, C.; Ralph, S.
10.1101/2021.06.27.450092 — cell biology — Posted on 2021-08-05
3441 Distinctive neural correlates of phonological processing and reading impairment in fetal alcohol-exposed adolescents with and without facial dysmorphology
Yu, X.; Dunstan, J.; Jacobson, S. W.; Molteno, C. D.; Lindinger, N. M.; Turesky, T. K.; Meintjes, E. M.; Jacobson, J. L.; Gaab, N.
10.1101/2021.08.04.454704 — neuroscience — Posted on 2021-08-05
3444 Extraction and high-throughput sequencing of oak heartwood DNA: assessing the feasibility of genome-wide DNA methylation profiling
Rossi, F.; Crnjar, A.; Comitani, F.; Feliciano, R.; Jahn, L.; Malim, G.; Southgate, L.; Kay, E.; Oakey, R.; Buggs, R.; Moir, A.; Kistler, L.; Rodriguez Mateos, A.; Molteni, C.; Schulz, R.
10.1101/2021.08.04.455090 — plant biology — Posted on 2021-08-05
3445 Change in the bladder function of rats with focal cerebral infarction induced by photochemically-induced thrombosis
Ota, Y.; Kubota, Y.; Hotta, Y.; Matsumoto, M.; Matsuyama, N.; Kato, T.; Hamakawa, T.; Kataoka, T.; Kimura, K.; Sawamoto, K.; Yasui, T.
10.1101/2021.08.04.455101 — physiology — Posted on 2021-08-04
3447 Evaluation of freshness and physicochemical characteristics of blankets of pirarucu (Arapaima gigas) bred in captivity at different ages in relation to the seasons
de Rosa, K. R.; da Silva, A. A.; de Barros, W. M.; Pedroso, A. L.; Ferreira, M. F. E.; Savay-da-Silva, L. K.; Mateus, L. A. d. F.; Kubota, E. H.
10.1101/2021.08.04.455103 — biochemistry — Posted on 2021-08-04
3449 Comparison of genetic variation between rare and common congeners of Dipodomys with estimates of contemporary and historical effective population size
Halsey, M.; Stuhler, J.; Bayona-Vasquez, N. J.; Platt, R. N.; Goetze, J. R.; Martin, R. E.; Matocha, K. G.; Bradley, R. D.; Stevens, R. D.; Ray, D. T.
10.1101/2021.08.04.455110 — genetics — Posted on 2021-08-04
3453 11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis
Davidson, C. T.; Miller, E.; Muir, M.; Dawson, J. C.; Lee, M.; Aitken, S.; Serrels, A.; Webster, S. P.; Homer, N. Z. M.; Andrew, R.; Brunton, V. G.; Hadoke, P. W. F.; Walker, B. R.
10.1101/2021.08.04.455121 — cancer biology — Posted on 2021-08-04
3454 Temporal and Spatial Dynamics of Hepatic Stellate Cell Activation in Intrahepatic Cholangiocarcinoma
Zhu, L.; Tian, C.; Li, L.; Pan, Q.; li, y.; Yang, W.; Fan, L.; Brown, A.; Morrison, M.; Dey, K. M.; Norris, E. J.; Yang, J. J.; Yu, J.; Glazer, E. S.
10.1101/2021.02.19.432035 — cancer biology — Posted on 2021-08-04
3459 Physiological and Metabolomic Consequences of Reduced Expression of the Drosophila brummer Triglyceride Lipase
Nazario Yepiz, N.; Fernandez Sobaberas, J.; Lyman, R.; Campbell, M.; Shankar, V.; Anholt, R.; Mackay, T. F. C.
10.1101/2021.08.04.455099 — genetics — Posted on 2021-08-04
3460 Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice
Yang, C.; Qiao, T.; Yu, J.; Wang, H.; Guo, Y.; Salameh, J.; Metterville, J.; Parsi, S.; Brown, R. H.; Cai, H.; Xu, Z.
10.1101/2021.08.04.455119 — genetics — Posted on 2021-08-04
3463 Population structure and genetic diversity of chickpea germplasms
jayaswal, D.; Yadav, g.; Jayaswall, K.; Bhandawat, A.; Singh, A. N.; Tilgam, J.; Rai, A. K.; Chaturvedi, R.; Kumar, A.; Kumar, S.
10.1101/2021.08.04.455107 — ecology — Posted on 2021-08-04
3464 Height-diameter allometry for tropical forest in northern Amazonia
Lima, R. B. d.; Görgens, E. B.; Elias, F.; de Abreu, J. C.; Baia, A. L.; de Oliveira, C. P.; Silva da Silva, D. A.; Batista, A. P. B.; Lima, R. C.; Sotta, E. D.
10.1101/2021.08.04.455098 — ecology — Posted on 2021-08-04
3465 Larval ecology and bionomics of Anopheles funestus in highland and lowland sites in western Kenya
Debrah, I.; Afrane, Y. A.; Amoah, L. E.; Ochwedo, K. O.; Mukabana, W. R.; Zhong, D.; Zhou, G.; Lee, M. C.; Onyango, S.; Magomere, E. O.; Atieli, H.; Githeko, A. K.; Yan, G.
10.1101/2021.08.04.455104 — ecology — Posted on 2021-08-04
3466 Preliminary analysis of a neotropical plant extract antiviral potential against Chikungunya and Mayaro viruses
Pires, E. C. F.; Da Silva, F. P.; Schallenberger, K.; Hermann, B. S.; Mallmann, L.; Santos, A. G. d.; Moura, W. S.; Oliveira, E. E.; Smagghe, G.; Ascencio, S. D.; Barbosa, R. D. S.; Mendes, I.; Fleck, J. D.; Ribeiro, B. M.; Aguiar, R. W. D. S.
10.1101/2021.08.04.455105 — microbiology — Posted on 2021-08-04
3467 Genomic diversity of bacteriophages infecting Rhodobacter capsulatus and their relatedness to its gene transfer agent RcGTA
Rapala, J.; Miller, B.; Garcia, M.; Dolan, M.; Bockman, M.; Hansson, M.; Russell, D. A.; Garlena, R. A.; Cresawn, S. G.; Westbye, A. B.; Beatty, J. T.; Alvey, R.; Bollivar, D. W.
10.1101/2021.08.04.455094 — microbiology — Posted on 2021-08-04
3468 IMMMUNE MEDIATORS IN IDIOPATHIC UVEITIS
Errera, M.-H.; Pratas, A.; Fisson, S.; Manicom, T.; Boubaya, M.; Sedira, N.; Heron, E.; Merabet, L.; Kobal, A.; Levy, V.; Warnet, J.-M.; Chaumeil, C.; Brignole-Baudouin, F.; Sahel, J.-A.; Goldschmidt, P.; Bodaghi, B.; Bloch-Queyrat, C.
10.1101/2021.08.04.455093 — immunology — Posted on 2021-08-04
3476 The role of antifreeze glycopeptides (AFGP) and polyvinyl alcohol/polyglycerol (X/Z-1000) cocktails as ice modulators during partial freezing of rat livers.
Tessier, S. N.; Haque, O.; Pendexter, C. A.; Cronin, S. E. J.; Weng, L.; Yeh, H.; Markmann, J. F.; Taylor, M. J.; Fahy, G. M.; Toner, M.; Uygun, K.
10.1101/2021.08.04.455092 — physiology — Posted on 2021-08-04
3477 BET inhibitors synergize with anti-PD1 by rescuing TCF1+ progenitor exhausted CD8+ T cells in Acute Myeloid Leukemia
Romine, K. A.; Cho, H. J.; Kosaka, Y.; Byrd, K.; Coy, J. L.; Flynn, P. A.; Newman, M. T.; Loo, C.; Scott, J.; Lind, E. F.
10.1101/2021.08.04.455147 — cancer biology — Posted on 2021-08-04
3485 Pulling on multiple threads of evidence to reveal tree species coexistence
McNickle, G. G.; Ritzi, M. V.; Blackstone, K. M. S.; Couture, J. J.; Nelson, T.; Hardiman, B. S.; Montague, M. S.; Jacobs, D. F.
10.1101/2021.07.13.452199 — ecology — Posted on 2021-08-04
3487 Surface expressed Plasmodium circumsporozoite protein (CSP) modulates cellular flexibility and motility
Patra, A. P.; Pathak, V.; Reddy, S. R.; Chhatre, A.; Dmello, C.; Narayan, S.; Singh, D.; Kota, A. K.; Koti, A. S. R.; Sharma, S.
10.1101/2021.08.04.455043 — cell biology — Posted on 2021-08-04
3492 MetA is a thermal fuse that arrests growth and protects Escherichia coli at elevated temperatures
Schink, S. J.; Gough, Z. H.; Biselli, E.; Huiman, M. G.; Chang, Y.-F.; Basan, M.; Gerland, U.
10.1101/2021.06.14.448417 — microbiology — Posted on 2021-08-04
3493 IL-13 promotes recovery from C. difficile infection
Donlan, A. N.; Leslie, J. L.; Simpson, M. E.; Petri, W. A.; Allen, J. E.; Petri, W. A.
10.1101/2021.08.03.454972 — immunology — Posted on 2021-08-04
3498 Liver Endothelium Promotes HER3-mediated Cell Survival in KRAS Wild-type and Mutant Colorectal Cancer Cells
Rathore, M.; Wright, M.; Bhattacharya, R.; Fan, F.; Vaziri-Gohar, A.; Winter, J.; Wang, Z.; Markowitz, S.; Willis, J.; Ellis, L.; Wang, R.
10.1101/2021.04.27.441690 — cancer biology — Posted on 2021-08-04
3499 GRAMD1C promotes autophagy initiation and mitochondrial bioenergetics through regulation of ER-mitochondria cholesterol transport
Ng, M. Y. W.; Charsou, C.; Lapao, A. S. D. S.; Singh, S.; Trachsel-Moncho, L.; Nakken, S.; Munson, M. J.; Simonsen, A.
10.1101/2021.08.04.455032 — biochemistry — Posted on 2021-08-04
3500 ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
Aykul, S.; Huang, L.; Wang, L.; Das, N.; Reisman, S.; Ray, Y.; Zhang, Q.; Rothman, N.; Nannuru, K. C.; Kamat, V.; Brydges, S.; Troncone, L.; Johnsen, L.; Yu, P. B.; Fazio, S.; Lees-Shepard, J.; Schutz, K.; Murphy, A. J.; Economides, A. N.; Idone, V.; Hatsell, S. J.
10.1101/2021.07.18.452865 — biochemistry — Posted on 2021-08-04
3501 Regulators of male and female sexual development critical for transmission of a malaria parasite
Russell, A. J. C.; Sanderson, T.; Bushell, E.; Talman, A. M.; Anar, B.; Girling, G.; Hunziker, M.; Kent, R. S.; Metcalf, T.; Montandon, R.; Pandey, V.; Roberts, A. B.; Sayers, C.; Schwach, F.; Rayner, J. C.; Voet, T.; Modrzynska, K. K.; Waters, A. P.; Lawniczak, M. K. N.; Billker, O.
10.1101/2021.08.04.455056 — genomics — Posted on 2021-08-04
3502 Strategies of tolerance reflected in two North American maple genomes
McEvoy, S. L.; Sezen, U. U.; Trouern-Trend, A.; McMahon, S. M.; Schaberg, P. G.; Yang, J.; Wegrzyn, J. L.; Swenson, N. G.
10.1101/2021.07.19.452996 — genomics — Posted on 2021-08-04
3503 Gene co-expression reveals the modularity and integration of C4 and CAM in Portulaca
Gilman, I. S.; Moreno-Villena, J. J.; Lewis, Z. R.; Goolsby, E. W.; Edwards, E. J.
10.1101/2021.07.07.451465 — evolutionary biology — Posted on 2021-08-04
3506 Heparan Sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE
Li, M.; Ong, C. Y.; Langouet-Astrie, C. J.; TAN, L.; Verma, A.; Yang, Y.; Zhang, X.; Shah, D.; Schmidt, E. P.; Xu, D.
10.1101/2021.06.17.448852 — cell biology — Posted on 2021-08-04
3507 Rock traits drive complex microbial communities at the edge of life
COLEINE, C.; DELGADO BAQUERIZO, M.; Zerboni, A.; Turchetti, B.; Buzzini, P.; Selbmann, L.
10.1101/2021.08.04.455018 — microbiology — Posted on 2021-08-04
3509 Helical Ordering of Envelope Associated Proteins and Glycoproteins in Respiratory Syncytial Virus Filamentous Virions
Conley, M. J.; Short, J. M.; Hutchings, J.; Burns, A. M.; Streetley, J.; Bakker, S. E.; Jaffery, H.; Stewart, M.; Power, B. J.; Zanetti, G.; Fearns, R.; Vijayakrishnan, S.; Bhella, D.
10.1101/2021.08.04.455049 — microbiology — Posted on 2021-08-04
3510 A U-Net model of local brain-age
Popescu, S. G.; Glocker, B.; Sharp, D. J.; Cole, J. H.
10.1101/2021.01.26.428243 — neuroscience — Posted on 2021-08-04
3515 HGFAC is a ChREBP Regulated Hepatokine that Enhances Glucose and Lipid Homeostasis
Sargsyan, A.; Doridot, L.; Hannou, S. A.; Tong, W.; Srinivasan, H.; Ivison, R.; Monn, R.; Kou, H. H.; Haldeman, J. M.; Arlotto, M.; White, P. J.; Grimsrud, P. A.; Astapova, I.; Tsai, L.; Herman, M. A.
10.1101/2021.07.29.454308 — physiology — Posted on 2021-08-04
3517 Loss of BCL-3 sensitises colorectal cancer cells to DNA damage, revealing a role for BCL-3 in double strand break repair by homologous recombination
Parker, C.; Chambers, A. C.; Flanagan, D.; Collard, T. J.; Ngo, G.; Baird, D. M.; Timms, P.; Morgan, R. G.; Sansom, O. J.; Williams, A. C.
10.1101/2021.08.03.454995 — cancer biology — Posted on 2021-08-04
3519 Probing the stability of the SpCas9-DNA complex after cleavage
Aldag, P.; Welzel, F.; Jakob, L.; Schmidbauer, A.; Rutkauskas, M.; Fettes, F.; Grohmann, D.; Seidel, R.
10.1101/2021.08.04.455019 — biophysics — Posted on 2021-08-04
3524 Better together - Relative retention time plus spectral matching improves automated glycan characterization using PGC-nLC-IT-ESI-MS/MS
Alagesan, K.; Schirmeister, F.; Moeginger, U.; Everest-Dass, A.; Altmann, F.; Seeberger, P. H.; von Itzstein, M.; Packer, N. H.; Kolarich, D.
10.1101/2021.08.04.451140 — biochemistry — Posted on 2021-08-04
3525 Molecular basis of UHRF1 allosteric activation for synergistic histone modification binding by PI5P
Mandal, P.; Yerkesh, Z.; Kharchenko, V.; Zandarashvili, L.; Bensaddek, D.; Jaremko, L.; Black, B. E.; Fischle, W.
10.1101/2021.08.04.455045 — biochemistry — Posted on 2021-08-04
3526 Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLRthat is shed by Furin
Susan-Resiga, D.; Girard, E.; Essalmani, R.; Roubtsova, A.; Marcinkiewicz, J.; Derbali, R. M.; Evagelidis, A.; Byun, J. H.; Lebeau, P. F.; Austin, R. C.; Seidah, N. G.
10.1101/2021.04.11.439364 — biochemistry — Posted on 2021-08-04
3528 Are members of the Anopheles fluviatilis complex conspecific?
Singh, O. P.; Sindhania, A.; Sharma, G.; Mishra, S.; Sharma, S. K.; Singh, P. K.; Das, M. K.
10.1101/2021.08.04.454551 — molecular biology — Posted on 2021-08-04
3529 Opposing roles of p38α phosphorylation and arginine methylation in driving TDP-43 proteinopathy.
Aikio, M.; Wobst, H. J.; Odeh, H. M.; Lee, B. L.; Class, B.; Ollerhead, T. A.; Mack, K. L.; Ford, A. F.; Barbieri, E. M.; Cupo, R. R.; Drake, L. E.; Castello, N.; Baral, A.; Dunlop, J.; Gitler, A.; Javaherian, A.; Finkbeiner, S.; Brown, D. G.; Moss, S. J.; Brandon, N. J.; Shorter, J.
10.1101/2021.08.04.455154 — molecular biology — Posted on 2021-08-04
3530 ComF is a key mediator in single-stranded DNA transport and handling during natural transformation
Damke, P. P.; Celma, L.; Kondekar, S.; Di Guilmi, A. M.; Marsin, S.; Depagne, J.; Veaute, X.; Legrand, P.; Walbott, H.; Vercruyssen, J.; Guerois, R.; Quevillon-Cheruel, S.; Radicella, J. P.
10.1101/2021.08.04.455028 — microbiology — Posted on 2021-08-04
3531 Contribution of single mutations to selected SARS-CoV-2 emerging variants Spike antigenicity
Gong, S. Y.; Chatterjee, D.; Richard, J.; Prevost, J.; Tauzin, A.; Gasser, R.; Bo, Y.; Vezina, D.; Goyette, G.; Gendron-Lepage, G.; Medjahed, H.; Roger, M.; Cote, M.; Finzi, A.
10.1101/2021.08.04.455140 — microbiology — Posted on 2021-08-04
3534 Learning the mutational landscape of the cancer genome
Sherman, M. A.; Yaari, A.; Priebe, O.; Dietlein, F.; Loh, P.-R.; Berger, B.
10.1101/2021.08.03.454669 — cancer biology — Posted on 2021-08-04
3536 ExhauFS: exhaustive search-based feature selection for classification and survival regression
Nersisyan, S.; Novosad, V.; Galatenko, A.; Sokolov, A.; Bokov, G.; Konovalov, A.; Alekseev, D.; Tonevitsky, A.
10.1101/2021.08.03.454798 — bioinformatics — Posted on 2021-08-04
3541 Ancestral contributions to contemporary European complex traits
Marnetto, D.; Pankratov, V.; Mondal, M.; Montinaro, F.; Pärna, K.; Vallini, L.; Molinaro, L.; Saag, L.; Loog, L.; Montagnese, S.; Costa, R.; Metspalu, M.; Eriksson, A.; Pagani, L.
10.1101/2021.08.03.454888 — genomics — Posted on 2021-08-04
3542 TAS-Seq: a robust and sensitive amplification method for beads-based scRNA-seq
Shichino, S.; Ueha, S.; Hashimoto, S.; Ogawa, T.; Aoki, H.; Wu, B.; Chen, C.-Y.; Kitabatake, M.; Ouji-Sageshima, N.; Hontsu, S.; Sawabata, N.; Kawaguchi, T.; Okayama, T.; Sugihara, E.; Ito, T.; Ikeo, K.; Sato, T.-a.; Matsushima, K.
10.1101/2021.08.03.454735 — genomics — Posted on 2021-08-04
3544 A rear-engine drives adherent tissue migration in vivo
Yamaguchi, N.; Zhang, Z.; Schneider, T.; Wang, B.; Panozzo, D.; Knaut, H.
10.1101/2021.08.03.454898 — developmental biology — Posted on 2021-08-04
3546 Structures of full-length glycoprotein hormone receptor signaling complexes
Duan, J.; Xu, P.; Cheng, X.; Mao, C.; Croll, T.; He, X.; Shi, J.; Luan, X.; Yin, W.; You, E.; Liu, Q.; Zhang, S.; Jiang, H.; Zhang, Y.; Jiang, Y.; Xu, H. E.
10.1101/2021.08.03.454894 — molecular biology — Posted on 2021-08-04
3547 MapToCleave: high-throughput profiling of microRNA biogenesis in living cells
Kang, W.; Fromm, B.; Houben, A. J. S.; Hoje, E.; Bezdan, D.; Arnan, C.; Thrane, K.; Asp, M.; Johnson, R. B.; Biryukova, I.; Friedländer, M. R.
10.1101/2021.08.03.454879 — molecular biology — Posted on 2021-08-04
3548 Altered low frequency brain rhythms precede changes in gamma power during tauopathy
Rodrigues, F. R.; Papanikolaou, A.; Holeniewska, J.; Phillips, K. G.; Saleem, A. B.; Solomon, S. G.
10.1101/2021.08.03.454865 — neuroscience — Posted on 2021-08-04
3555 The role of actin and myosin II in the cell cortex of adhered and suspended cells
Flormann, D.; Kaub, K.; Vesperini, D.; Schu, M.; Anton, C.; Pohland, M.; Kainka, L.; Montalvo Bereau, G.; Janshoff, A.; Hawkins, R.; Terriac, E.; Lautenschlaeger, F.
10.1101/2021.08.03.454901 — biophysics — Posted on 2021-08-04
3558 Nanofibrous PEDOT-Carbon Composite on Flexible Probes for Soft Neural Interfacing
vajrala, v. s.; Saunier, v.; Nowak, L. G.; Flahaut, E.; Bergaud, C.; Maziz, A.
10.1101/2021.08.03.454873 — bioengineering — Posted on 2021-08-04
3560 IMPDH1 retinal variants control filament architecture to tune allosteric regulation
BURRELL, A. L.; Nie, C.; Said, M.; Simonet, J. C.; Fernandez-Justel, D.; Johnson, M. C.; Quispe, J.; Buey, R. M.; Peterson, J. R.; Kollman, J. M.
10.1101/2021.08.03.454821 — biochemistry — Posted on 2021-08-04
3561 A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia
Harada, T.; Heshmati, Y.; Kalfon, J.; Ferrucio, J. X.; Perez, M.; Ewers, J.; Kossenkov, A.; Ellegast, J. M.; Yi, J. S.; Bowker, A.; Zhu, Q.; Eagle, K.; Dempster, J. M.; Kugener, G.; Wickramasinghe, J.; Herbert, Z. T.; Li, C. H.; Koren, J. V.; Weinstock, D. M.; Paralkar, V. R.; Nabet, B.; Lin, C. Y.; Dharia, N. V.; Stegmaier, K.; Orkin, S. H.; Pimkin, M.
10.1101/2021.08.03.454902 — genomics — Posted on 2021-08-04
3566 Redox state and cellular uptake of copper is regulated by the N-terminus of human Copper Transporter-1
Kar, S.; Sen, S.; Maji, S.; Ruturaj, ; Paul, R.; Dutt, S.; Mondal, B.; Schreiner, R.; Boulan, E. R.; Sengupta, D.; Gupta, A.
10.1101/2021.08.03.454867 — cell biology — Posted on 2021-08-04
3567 Cooled SPAD array detector for low light-dose fluorescence laser scanning microscopy
Slenders, E.; Perego, E.; Buttafava, M.; Tortarolo, G.; Conca, E.; Zappone, S.; Pierzynska-Mach, A.; Villa, F.; Petrini, E. M.; Barberis, A.; Tosi, A.; Vicidomini, G.
10.1101/2021.08.03.454878 — biophysics — Posted on 2021-08-04
3568 Single-sequence protein structure prediction using language models from deep learning
Chowdhury, R.; Bouatta, N.; Biswas, S.; Rochereau, C.; Church, G. M.; Sorger, P. K.; AlQuraishi, M. N.
10.1101/2021.08.02.454840 — bioinformatics — Posted on 2021-08-04
3569 Liposomal Dexamethasone Reduces A/H1N1 Influenza-Associated Morbidity in Mice
Seok, S. H.; Na, Y.; Kwon, J. W.; Quan, H.; Song, J.; Chung, H.; Jung, D.; Hong, J.
10.1101/2021.08.02.454850 — immunology — Posted on 2021-08-04
3570 Two-dimensional multiplexed assay for rapid and deep SARS-CoV-2 serology profiling and for machine learning prediction of neutralization capacity
Koide, A.; Panchenko, T.; Wang, C.; Thannickal, S. A.; Romero, L. A.; Teng, K. W.; Li, F.-Z.; Akkapeddi, P.; Corrado, A. D.; Caro, J.; Diefenbach, C.; Samanovic, M. I.; Mulligan, M. J.; Hattori, T.; Stapleford, K. A.; Li, H. J.; Koide, S.
10.1101/2021.08.03.454782 — immunology — Posted on 2021-08-04
3573 Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice
Chen, Z.; Raj, A.; Prateek, G. V.; Di Francesco, A.; Liu, J.; Keyes, B. E.; Kolumam, G.; Jojic, V.; Freund, A.
10.1101/2021.08.02.454830 — systems biology — Posted on 2021-08-04
3575 Automatic segmentation of the rat brain hippocampus in MRI after traumatic brain injury
De Feo, R.; Hamalainen, E.; Manninen, E.; Immonen, R.; Valverde, J. M.; Ndode-Ekane, X. E.; Grohn, O.; Pitkanen, A.; Tohka, J.
10.1101/2021.08.03.454863 — bioinformatics — Posted on 2021-08-04
3576 Bacteria.guru: comparative transcriptomics and co-expression database for bacterial pathogens
Lim, P. K.; Davey, E. E.; Wee, S.; Seetoh, W. S.; Goh, J. C.; Zheng, X.; Phang, S. K. A.; Seah, E. S. K.; Ng, J. W. Z.; Wee, X. J. H.; Quek, A. J. H.; Lim, J. J.; Rodrigues, E. E.; Lee, H.; Lim, C. Y.; Tan, W. Z.; Dan, Y. R.; Lee, B.; Chee, S. E. L.; Lim, Z. Z. E.; Guan, J. S.; Tan, I. J. L.; Arong, T. J.; Mutwil, M.
10.1101/2021.08.02.454836 — bioinformatics — Posted on 2021-08-04
3578 Predictive framework of macrophage activation
Sanin, D. E.; Ge, Y.; Marinkovic, E.; Kabat, A. M.; Castoldi, A.; Caputa, G.; Grzes, K. M.; Curtis, J. D.; Willenborg, S.; Dichtl, S.; Reinhardt, S.; Dahl, A.; Pearce, E. L.; Eming, S. A.; Gerbaulet, A.; Roers, A.; Murray, P. J.; Pearce, E. J.
10.1101/2021.08.02.454825 — immunology — Posted on 2021-08-04
3579 Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and aging
Freitag, K.; Eede, P.; Ivanov, A.; Schneeberger, S.; Borodina, T.; Sauer, S.; Beule, D.; Heppner, F. L.
10.1101/2021.08.02.454573 — neuroscience — Posted on 2021-08-04
3584 High expression of VRT2 during wheat spikelet initiation increases the number of rudimentary basal spikelets
Backhaus, A. E.; Lister, A.; Tomkins, M.; Adamski, N. M.; Simmonds, J.; Macaulay, I. C.; Morris, R. J.; Haerty, W.; Uauy, C.
10.1101/2021.08.03.454952 — plant biology — Posted on 2021-08-04
3585 Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level
Leary, S.; Gaudieri, S.; Parker, M. D.; Chopra, A.; James, I.; Pakala, S.; Alves, E.; John, M.; Lindsey, B. B.; Keeley, A. J.; Rowland-Jones, S. L.; Swanson, M.; Ostrov, D. A.; Bubenik, J. L.; Das, S.; Sidney, J.; Sette, A.; COVID-19 Genomics Consortium UK, ; de Silva, T. I.; Phillips, E. J.; Mallal, S.
10.1101/2020.04.10.029454 — microbiology — Posted on 2021-08-04
3590 SARS-CoV-2 Delta variant pathogenesis and host response in Syrian hamsters
Mohandas, S.; Yadav, P. D.; Shete, A. A.; Nyayanit, D.; Sapkal, G. N.; Lole, K.; Gupta, N.
10.1101/2021.07.24.453631 — molecular biology — Posted on 2021-08-04
3591 Design, immunogenicity and efficacy of a Pan-SARS-CoV-2 synthetic DNA vaccine
Reed, C. C.; Schultheis, K.; Andrade, V. M.; Kalia, R.; Tur, J.; Schouest, B.; Elwood, D.; Walters, J. N.; Maricic, I.; Doan, A.; Vazquez, M.; Eblimit, Z.; Pezzoli, P.; Amante, D.; Porto, M.; Narvaez, B.; Lok, M.; Spence, B.; Bradette, H.; Horn, H.; Yang, M.; Fader, J.; Ferrer, R.; Weiner, D. B.; Kar, S.; Kim, J. J.; Humeau, L. M.; Ramos, S. J.; Smith, T. R.; Broderick, K. E.
10.1101/2021.05.11.443592 — immunology — Posted on 2021-08-04
3593 Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression
Kim, H.; Gao, E. B.; Draper, A.; Berens, N. C.; Vihma, H.; Zhang, X.; Higashi-Howard, A.; Ritola, K.; Simon, J.; Kennedy, A. J.; Philpot, B.
10.1101/2021.08.02.454783 — neuroscience — Posted on 2021-08-04
3596 Excretion of triacylglycerol as a matrix lipid facilitating apoplastic accumulation of a lipophilic metabolite shikonin.
Tatsumi, K.; Ichino, T.; Isaka, N.; Sugiyama, A.; Okazaki, Y.; Higashi, Y.; Kajikawa, M.; Fukuzawa, H.; Toyooka, K.; Sato, M.; Ichi, I.; Shimomura, K.; Ohta, H.; Saito, K.; Yazaki, K.
10.1101/2021.08.04.455005 — plant biology — Posted on 2021-08-04
3598 The sodium leak channel NALCN encodes the major background sodium ion conductance in murine anterior pituitary cells
Belal, M.; Mucha, M.; Monteil, A.; Winyard, P. G.; Pawlak, R.; Walker, J. J.; Tabak, J.; Belle, M.
10.1101/2021.08.02.454810 — physiology — Posted on 2021-08-04
3600 Targeted in silico characterization of fusion transcripts in tumor and normal tissues via FusionInspector
Haas, B.; Dobin, A.; Ghandi, M.; Van Arsdale, A.; Tickle, T. L.; Robinson, J. T.; Gilliani, R.; Kasif, S.; Regev, A.
10.1101/2021.08.02.454639 — bioinformatics — Posted on 2021-08-04
3605 Structural (dys)connectivity associates with cholinergic cell density of the nucleus basalis of Meynert in Alzheimer's disease
Lin, C.-P.; Frigerio, I.; Boon, B. D.; Zhou, Z.; Rozemuller, A. J.; Bouwman, F.; Schoonheim, M. M.; van de Berg, W. D.; Jonkman, L.
10.1101/2021.08.02.454716 — neuroscience — Posted on 2021-08-04
3606 Learning shapes cortical dynamics to enhance integration of relevant sensory input
Chadwick, A.; Khan, A.; Poort, J.; Blot, A.; Hofer, S.; Mrsic-Flogel, T.; Sahani, M.
10.1101/2021.08.02.454726 — neuroscience — Posted on 2021-08-04
3607 Involvement of ASIC1a channels in the spinal processing of pain information by deep projection neurons
Chafai, M.; Delrocq, A.; Inquimbert, P.; Pidoux, L.; Delanoe, K.; Lingueglia, E.; Veltz, R.; DEVAL, E.
10.1101/2021.08.02.454740 — neuroscience — Posted on 2021-08-04
3608 Influence of anatomical features of different brain regions on the spatial localization of fiber photometry signals
Montinaro, C.; Pisanello, M.; Bianco, M.; Spagnolo, B.; Pisano, F.; Balena, A.; De Nuccio, F.; Lofrumento, D. D.; Verri, T.; De Vittorio, M.; Pisanello, F.
10.1101/2021.08.02.454755 — neuroscience — Posted on 2021-08-04
3612 Cell type-specific biotin labeling in vivo resolves regional neuronal proteomic differences in mouse brain
Rayaprolu, S.; Bitarafan, S.; Betarbet, R.; Sunna, S. N.; Cheng, L.; Xiao, H.; Bagchi, P.; Duong, D. M.; Nelson, R.; Goettemoeller, A. M.; Olah, V. J.; Rowan, M. J.; Levey, A. I.; Wood, L. B.; Seyfried, N. T.; Rangaraju, S.
10.1101/2021.08.03.454921 — neuroscience — Posted on 2021-08-04
3613 Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth
Cui, Z.; Pines, A. R.; Larsen, B.; Sydnor, V. J.; Li, H.; Adebimpe, A.; Alexander-Bloch, A. F.; Bassett, D. S.; Bertolero, M.; Calkins, M. E.; Davatzikos, C.; Fair, D. A.; Gur, R. C.; Gur, R. E.; Moore, T. M.; Shanmugan, S.; Shinohara, R. T.; Vogel, J. W.; Xia, C. H.; Fan, Y.; Satterthwaite, T. D.
10.1101/2021.08.02.454763 — neuroscience — Posted on 2021-08-04
3614 Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling
Bisht, K.; Okojie, K. A.; Sharma, K. P.; Lentferink, D. H.; Sun, Y.-Y.; Chen, H.-R.; Uweru, J. O.; Amancherla, S.; Calcuttawala, Z.; Campos-Salazar, A. B.; Corliss, B.; Jabbour, L.; Benderoth, J.; Friestad, B.; Mills, W. A.; Isakson, B. E.; Tremblay, M.-E.; Kuan, C.-Y.; Eyo, U. B.
10.1101/2021.08.02.454769 — neuroscience — Posted on 2021-08-04
3616 High-resolution reconstruction and deconvolution of array detector images
Prigent, S.; Dutertre, S.; Bidaud-Meynard, A.; Bertolin, G.; Michaux, G.; Kervrann, C.
10.1101/2021.08.02.454749 — bioinformatics — Posted on 2021-08-04
3618 Rapid Prototyping of Cell Culture Microdevices Using Parylene-Coated 3D Prints
O'Grady, B.; Geuy, M.; Kim, H.; Balotin, K.; Allchin, E.; Florian, D.; Bute, N.; Scott, T.; Lowen, G.; Fricker, C.; Guelcher, S.; Wikswo, J.; Bellan, L.; Lippmann, E.
10.1101/2021.08.02.454773 — bioengineering — Posted on 2021-08-04
3619 Non-Viral Engineering of CAR-NK and CAR-T cells using the Tc Buster Transposon System™
Pomeroy, E. J.; Lahr, W. S.; Chang, J. W.; Krueger, J. B.; Wick, B. J.; Slipek, N. J.; Skeate, J. G.; Webber, B. R.; Moriarity, B. S.
10.1101/2021.08.02.454772 — bioengineering — Posted on 2021-08-04
3620 Long-distance dispersal of pigeons and doves generated new ecological opportunities for host-switching and adaptive radiation by their parasites
Boyd, B. M.; Nguyen, N.-P.; Allen, J. M.; Waterhouse, R. M.; Vo, K. B.; Sweet, A. D.; Clayton, D. H.; Bush, S. E.; Shapiro, M. D.; Johnson, K. P.
10.1101/2021.08.02.454751 — evolutionary biology — Posted on 2021-08-04
3622 Neurotensin neurons in the central extended amygdala control energy balance
Furlan, A.; Corona, A.; Boyle, S.; Sharma, R.; Rubino, R.; Habel, J.; Gablenz, E. C.; Giovanniello, J.; Beyaz, S.; Janowitz, T.; Shea, S. D.; Li, B.
10.1101/2021.08.03.454970 — neuroscience — Posted on 2021-08-04
3623 Low amplitude burst detection of catecholamines
Eltahir, A. M.; White, J.; Lohrenz, T. M.; Montague, R.
10.1101/2021.08.02.454747 — neuroscience — Posted on 2021-08-04
3624 Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity
Griesius, S.; O'Donnell, C.; Waldron, S.; Thomas, K. L.; Dwyer, D. M.; Wilkinson, L. S.; Hall, J.; Robinson, E. S. J.; Mellor, J. R.
10.1101/2021.08.02.454736 — neuroscience — Posted on 2021-08-04
3626 Uptake of Fe-fraxetin complexes, an IRT1 independent strategy for iron acquisition in Arabidopsis thaliana.
ROBE, K.; STASSEN, m.; CHAMIEH, j.; GONZALEZ, p.; HEM, s.; SANTONI, V.; DUBOS, c.; IZQUIERDO ALEGRE, e.
10.1101/2021.08.03.454955 — plant biology — Posted on 2021-08-04
3630 Pathfinder: A gamified measure to integrate general cognitive ability into the biological, medical, and behavioural sciences
Malanchini, M.; Rimfeld, K.; Gidziela, A.; Cheesman, R.; Allegrini, A. G.; Shakeshaft, N.; Schofield, K.; Packer, A.; Ogden, R.; McMillan, A.; Ritchie, S. J.; Dale, P. S.; Eley, T. C.; von Stumm, S.; Plomin, R.
10.1101/2021.02.10.430571 — genetics — Posted on 2021-08-04
3631 Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development
Tamura, S.; Mukaide, M.; Katsuragi, Y.; Fujii, W.; Odaira, K.; Suzuki, N.; Okamoto, S.; Suzuki, A.; Kanematsu, T.; Katsumi, A.; Takagi, A.; Suzuki-Inoue, K.; Matsushita, T.; Kojima, T.; Hayakawa, F.
10.1101/2021.07.05.451096 — developmental biology — Posted on 2021-08-04
3633 A low repeated dose of Δ9-tetrahydrocannabinol affects memory performance through serotonergic signalling in mice
Galera-Lopez, L.; Salgado-Mendialdua, V.; Moreno, E.; Bergada-Martinez, A.; Hoffman, A.; Manzanares-Sierra, I.; Busquets-Garcia, A.; Casado, V.; Lupica, C.; Maldonado, R.; Ozaita, A.
10.1101/2021.05.31.446448 — neuroscience — Posted on 2021-08-04
3637 Using Deep Learning to Count Monarch Butterflies in Dense Clusters
Patel, S.; Kulkarni, A.; Mukhopadhyay, A.; Gujar, K.; Roode, J. d.
10.1101/2021.07.23.453502 — bioengineering — Posted on 2021-08-04
3640 A vibrissa pathway that activates the limbic system
Kleinfeld, D.; Deschenes, M.; Elbaz, M.; Callado Perez, A.; Foo, C.; Zhao, S.; Demers, M.
10.1101/2021.08.02.454720 — neuroscience — Posted on 2021-08-04
3641 Phylogenomic analyses of echinoid diversification prompt a re-evaluation of their fossil record
Mongiardino Koch, N.; Thompson, J. R.; Hatch, A. S.; McCowin, M. F.; Armstrong, F.; Coppard, S. E.; Aguilera, F.; Bronstein, O.; Kroh, A.; Mooi, R.; Rouse, G. W.
10.1101/2021.07.19.453013 — evolutionary biology — Posted on 2021-08-04
3644 A primeval mechanism of tolerance to desiccation based on glycolic acid saves neurons from ischemia in mammals by reducing intracellular calcium-mediated excitotoxicity
Chovsepian, A.; Berchtold, D.; Winek, K.; Mamrak, U.; Ramirez-Alvarez, I.; Dening, Y.; Golubczyk, D.; Weitbrecht, L.; Dames, C.; Aillery, M.; Fernandez-Sanz, C.; Gajewski, Z.; Dieterich, M.; Janowski, M.; Falkai, P.; Walczak, P.; Plesnila, N.; Meisel, A.; Pan-Montojo, F. J.
10.1101/2020.11.24.396051 — neuroscience — Posted on 2021-08-04
3647 Functional non-coding SNPs in human endothelial cells fine-map vascular trait associations
Toropainen, A.; Stolze, L. K.; Ord, T.; Whalen, M. B.; Torrell, P. M.; Link, V. M.; Kaikkonen, M. U.; Romanoski, C. E.
10.1101/2021.08.03.454513 — genetics — Posted on 2021-08-03
3648 Single Cell Atlas of Human Dura Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response
Wang, A. Z.; Bowman-Kirigin, J.; Desai, R.; Patel, P.; Patel, B.; Khan, S.; Bender, D.; Marlin, M. C.; Liu, J.; Osbun, J.; Leuthardt, E.; Chicoine, M.; Dacey, R.; Zipfel, G.; Kim, A.; Petti, A. A.; Dunn, G.
10.1101/2021.08.03.454066 — immunology — Posted on 2021-08-03
3654 Genetic screens identify connections between ribosome recycling and nonsense mediated decay
D'Orazio, K. N.; Lessen, L. N.; Veltri, A. J.; Neiman, Z.; Pacheco, M. E.; Loll-Krippleber, R.; Brown, G. W.; Green, R.
10.1101/2021.08.03.454884 — molecular biology — Posted on 2021-08-03
3656 Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis
Wilburn, K. M.; Montague, C. R.; Qin, B.; Woods, A. K.; Love, M. S.; McNamara, C. W.; Schultz, P. G.; Southard, T. L.; Huang, L.; Petrassi, H. M.; VanderVen, B. C.
10.1101/2021.08.03.454881 — microbiology — Posted on 2021-08-03
3659 Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity
Fu, R.; He, W.; Dou, J.; Villarreal, O. D.; Bedford, E.; Wang, H.; Hou, C.; Zhang, L.; Wang, Y.; Chen, Y.; Gao, X. S.; Depken, M.; Xu, H.
10.1101/2021.08.02.454843 — systems biology — Posted on 2021-08-03
3664 A novel mobile RND-type efflux pump gene cluster, tmexC3D2-toprJ3, confers tigecycline resistance in Pseudomonas alcaligenes
Maehana, S.; Eda, R.; Niida, N.; Hirabayashi, A.; Sakai, K.; Furukawa, T.; Sei, K.; Kitasato, H.; Suzuki, M.
10.1101/2021.07.26.453812 — microbiology — Posted on 2021-08-03
3665 A clinically validated human saliva metatranscriptomic test for global systems biology studies
Toma, R.; Cai, Y.; Ogundijo, O.; Gline, S.; Demusaj, D.; Duval, N.; Banavar, G.; Vuyisich, M.
10.1101/2021.08.03.454950 — microbiology — Posted on 2021-08-03
3671 Perceptual coupling and decoupling of the default mode network during mind-wandering and reading
Zhang, M.; Bernhardt, B.; Wang, X.; Varga, D.; Krieger-Redwood, K.; Royer, J.; Rodriguez-Cruces, R.; Vos de Wael, R.; Margulies, D. S.; Smallwood, J.; Jefferies, E.
10.1101/2020.10.03.324947 — neuroscience — Posted on 2021-08-03
3678 Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases
Joshi, J.; Li, Q.; Garcia-Garcia, J. D.; Leong, B. J.; Hu, Y.; Bruner, S. D.; Hanson, A. D.
10.1101/2021.08.03.453570 — synthetic biology — Posted on 2021-08-03
3681 The linkage of methionine addiction, overmethylation of histone H3 lysines and malignancy demonstrated when cancer cells revert to methionine-independence
Yamamoto, J.; Inubushi, S.; Han, Q.; Tashiro, Y.; Sugisawa, N.; Hamada, K.; Aoki, Y.; Miyake, K.; Matsuyama, R.; Bouvet, M.; Clarke, S. G.; Endo, I.; Hoffman, R. M.
10.1101/2020.12.04.412437 — cancer biology — Posted on 2021-08-03
3683 Bioactivity assessment of natural compounds using machine learning models based on drug target similarity
Periwal, V.; Bassler, S.; Andrejev, S.; Gabrielli, N.; Patil, K. R.; Typas, A.; Patil, K. R.
10.1101/2020.11.06.371112 — bioinformatics — Posted on 2021-08-03
3687 What are housekeeping genes?
Joshi, C. J.; Ke, W.; Drangowska-Way, A.; O'Rourke, E. J.; Lewis, N. E.
10.1101/2021.02.14.431149 — evolutionary biology — Posted on 2021-08-03
3690 Dynamic evolution of bacterial ligand recognition by formyl peptide receptors
Paterson, N. M.; Al-Zubieri, H.; Ragona, J.; Tirado, J.; Geisbrecht, B. V.; Barber, M. F.
10.1101/2021.08.02.454796 — evolutionary biology — Posted on 2021-08-03
3691 A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal MRSA populations
Zou, G.; MATUSZEWSKA, M.; Jia, M.; ZHOU, J.; Ba, X.; DUAN, J.; ZHANG, C.; ZHAO, J.; TAO, M.; Fan, J.; ZHANG, X.; JIN, W.; CUI, T.; ZENG, X.; JIA, M.; QIAN, X.; HUANG, C.; ZHUO, W.; YAO, Z.; Zhang, L.; Li, S.; Li, L.; HUANG, Q.; Wu, B.; Chen, H.; Tucker, A. W.; Grant, A. J.; Holmes, M. A.; Zhou, R.
10.1101/2021.08.02.454852 — microbiology — Posted on 2021-08-03
3693 Microbial byproducts determine reproductive fitness of free-living and parasitic nematodes
Venzon, M.; Das, R.; Luciano, D. J.; Park, H. S.; Kool, E. T.; Belasco, J. G.; Hubbard, E. J. A.; Cadwell, K.
10.1101/2021.08.02.454806 — microbiology — Posted on 2021-08-03
3694 High Level of Interaction between Phages and Bacteria in an Artisanal Raw Milk Cheese Microbial Community
Queiroz, L. L.; Lacorte, G. A.; Isidorio, W. R.; Landgraf, M.; Franco, B. D. G. d. M.; Pinto, U. M.; Hoffmann, C.
10.1101/2021.08.03.454940 — microbiology — Posted on 2021-08-03
3695 Dissemination and pathogenesis of toxigenic Clostridium perfringens strains linked to neonatal intensive care units and Necrotising Enterocolitis
Kiu, R.; Shaw, A.; Sim, K.; Bedwell, H.; Cornwell, E.; Pickard, D.; Belteki, G.; Malsom, J.; Philips, S.; Young, G.; Schofield, Z.; Alcon-Giner, C.; Berrington, J.; Stewart, C.; Dougan, G.; Clarke, P.; Douce, G.; Kroll, J. S.; Hall, L. J.
10.1101/2021.08.03.454877 — microbiology — Posted on 2021-08-03
3696 Biofilm Interaction Mapping and Analysis (BIMA): A tool for deconstructing interspecific interactions in co-culture biofilms
Kosina, S. M.; Rademacher, P.; Wetmore, K. M.; de Raad, M.; Zemla, M.; Zane, G. M.; Zulovich, J. J.; Chakraborty, R.; Bowen, B. P.; Wall, J. D.; Auer, M.; Arkin, A. P.; Deutschbauer, A. M.; Northen, T. R.
10.1101/2021.08.03.454817 — microbiology — Posted on 2021-08-03
3697 A CTP-dependent gating mechanism enables ParB spreading on DNA
Jalal, A. S. B.; Tran, N. T.; Stevenson, C. E. M.; Chimthanawala, A.; Badrinarayanan, A.; Lawson, D. M.; Le, T. B. K.
10.1101/816959 — microbiology — Posted on 2021-08-03
3703 ZeBox: A novel non-intrusivecontinuous-use technology to trap and killairborne microbes
Phadke, K. S.; Madival, D. G.; Venkatraman, J.; Kundu, D.; Ramanujan, K. S.; Holla, N.; Arakeri, J.; Tomar, G.; Datta, S.; Ghatak, A.
10.1101/2021.08.02.454789 — microbiology — Posted on 2021-08-03
3704 Clostridioides difficile binary toxin binding component (CDTb) increases virulence in a hamster model
Simpson, M.; Bilverstone, T.; Leslie, J. L.; Donlan, A.; Uddin, M. J.; Petri, W.; Marin, N.; Schwan, C.; Kuehne, S.; Minton, N. P.; Petri, W. A.
10.1101/2021.08.03.454966 — microbiology — Posted on 2021-08-03
3707 Lack of Cdk5 activity is involved on Dopamine Transporter expression and function: Evidences from an animal model of Attention-Deficit Hyperactivity Disorder
Fernandez, G.; Krapacher, F.; Ferreras, S.; Quasollo, G.; Mari, M. M.; Pisano, M. V.; Montemerlo, A.; Rubianes, M. D.; Bregonzio, C.; Arias, C.; Paglini, M. G.
10.1101/2021.03.19.436226 — neuroscience — Posted on 2021-08-03
3708 Resurrecting essential amino acid biosynthesis in a mammalian cell
Trolle, J.; McBee, R. M.; Kaufman, A.; Pinglay, S.; Berger, H.; German, S.; Liu, L.; Shen, M. J.; Guo, X.; Martin, J. A.; Pacold, M.; Jones, D. R.; Boeke, J. D.; Wang, H. H.
10.1101/2021.08.03.454854 — synthetic biology — Posted on 2021-08-03
3709 A programmable probiotic encapsulation system enhances therapeutic delivery in vivo
Harimoto, T.; Hahn, J.; Chen, Y.-Y.; Im, J.; Zhang, J.; Hou, N.; Li, F.; Coker, C.; Gray, K.; Harr, N.; Chowdhury, S.; Pu, K.; Nimura, C.; Arpaia, N.; Leong, K. W.; Danino, T.
10.1101/2021.08.03.454638 — synthetic biology — Posted on 2021-08-03
3711 New insights into the earlier evolutionary history of epiphytic macrolichens
Yang, Q.; Wang, Y.; Lucking, R.; Lumbsch, H. T.; Wang, X.; Du, Z.; Chen, Y.; Bai, M.; Ren, D.; Wei, J.; Li, H.; Wang, Y.; Wei, X.
10.1101/2021.08.02.454570 — paleontology — Posted on 2021-08-03
3715 Black Dots: Microcontact-Printed, Reference-Free Traction Force Microscopy
Beussman, K. M.; Mollica, M. Y.; Leonard, A.; Miles, J.; Hocter, J.; Song, Z.; Stolla, M.; Han, S. J.; Emery, A.; Thomas, W. E.; Sniadecki, N. J.
10.1101/2021.08.02.454500 — bioengineering — Posted on 2021-08-03
3718 A Chromosome-level Genome Assembly of the Reed Warbler (Acrocephalus scirpaceus)
Lo Cascio Saetre, C.; Eroukhmanoff, F. D.; Rönkä, K.; Kluen, E.; Thorogood, R.; Torrance, J.; Tracey, A.; Chow, W.; Pelan, S.; Howe, K.; Jakobsen, K. S.; Torresen, O. K.
10.1101/2021.08.02.454714 — genomics — Posted on 2021-08-03
3719 Biomorphogenic feedbacks and the spatial organisation of a dominant grass steer dune development
Bonte, D.; Batsleer, F.; Provoost, S.; Reijers, V.; Vandegehuchte, M.; Van De Walle, R.; Dan, S.; Matheve, H.; Rauwoens, P.; Strypsteen, G.; Suzuki, T.; Verwaest, T.; Hillaert, J.
10.1101/2021.08.02.454713 — ecology — Posted on 2021-08-03
3722 SARS-CoV-2 B.1.351 (beta) variant shows enhanced infectivity in K18-hACE2 transgenic mice and expanded tropism to wildtype mice compared to B.1 variant
Tarres-Freixas, F.; Trinite, B.; Pons-Grifols, A.; Romero-Durana, M.; Riveira-Munoz, E.; Avila-Nieto, C.; Perez, M.; Garcia-Vidal, E.; Perez-Zsolt, D.; Munoz-Basagoiti, J.; Raich-Regue, D.; Izquierdo-Useros, N.; Blanco, I.; Noguera-Julian, M.; Guallar, V.; Lepore, R.; Valencia, A.; Vergara-Alert, J.; Clotet, B.; Ballana, E.; Carrillo, J.; Segales, J.; Blanco, J.
10.1101/2021.08.03.454861 — microbiology — Posted on 2021-08-03
3723 Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern
Mothes, W.; Li, W.; Chen, Y.; Prevost, J.; Ullah, I.; Lu, M.; Gong, S. Y.; Tauzin, A.; Gasser, R.; Vezina, D.; Anand, S. P.; Goyette, G.; Chaterjee, D.; Ding, S.; Tolbert, W. D.; Grunst, M. W.; Bo, Y.; Zhang, S.; Richard, J.; Zhou, F.; Huang, R. K.; Esser, L.; Zeher, A.; Cote, M.; Kumar, P.; Sodroski, J.; Xia, D.; Uchil, P. D.; Pazgier, M.; Finzi, A.
10.1101/2021.08.02.454546 — microbiology — Posted on 2021-08-03
3724 Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamsters
Kulkarni, R.; Chen, W.-C.; Lee, Y.; Kao, C.-F.; Hu, S.-L.; Ma, H.-H.; Jan, J.-T.; Liao, C.-C.; Liang, J.-J.; Ko, H.-Y.; Sun, C.-P.; Lin, Y.-S.; Wang, Y.-C.; Wei, S.-C.; Lin, Y.-L.; Ma, C.; Chao, Y.-C.; Chou, Y.-C.; Chang, W.
10.1101/2021.08.03.454910 — immunology — Posted on 2021-08-03
3725 Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit.
Hurlburt, N.; Homad, L.; Siha, I.; Jenewein, M. F.; MacCamy, A.; Wan, Y.-H.; Boonyaratanakornkit, J.; Sholukh, A. M.; Zhou, P.; Burton, D.; Andrabi, R.; Stamatatos, L.; Pancera, M.; McGuire, A.
10.1101/2021.08.02.454829 — immunology — Posted on 2021-08-03
3726 Protective mucosal immunity against SARS-CoV-2 after heterologous systemic RNA-mucosal adenoviral vector immunization
Lapuente, D.; Fuchs, J.; Willar, J.; Antao, A. V.; Everlein, V.; Uhlig, N.; Issmail, L.; Schmidt, A.; Oltmanns, F.; Peter, A. S.; Mueller-Schmucker, S.; Irrgang, P.; Fraedrich, K.; Cara, A.; Hoffmann, M.; Poehlmann, S.; Ensser, A.; Pertl, C.; Willert, T.; Thirion, C.; Grunwald, T.; Ueberla, K.; Tenbusch, M.
10.1101/2021.08.03.454858 — immunology — Posted on 2021-08-03
3729 Myth-busting the provider-user relationship for digital sequence information
Scholz, A. H.; Lange, M.; Habekost, P.; Oldham, P.; Cancio, I.; Cochrane, G.; Freitag, J.
10.1101/2021.08.02.454535 — scientific communication and education — Posted on 2021-08-03
3730 Mis-regulation of the Nucleoporins 98 and 96 lead to defects in protein synthesis that promote hallmarks of tumorigenesis.
Pulianmackal, A. J.; Kanakousaki, K.; Flegel, K. A.; Grushko, O. G.; Gourley, E.; Rozich, E.; Buttitta, L. A.
10.1101/2021.08.02.454839 — developmental biology — Posted on 2021-08-03
3732 Gene-dependent yeast cell death pathway requires AP-3 vesicle trafficking leading to vacuole membrane permeabilization
Stolp, Z. D.; Kulkarni, M.; Liu, Y.; Zhu, C.; Jalisi, A.; Lin, S.; Casadevall, A.; Cunningham, K. W.; Pineda, F. J.; Teng, X.; Hardwick, J. M.
10.1101/2021.08.02.454728 — cell biology — Posted on 2021-08-03
3734 High temperature perception in leaves promotes vascular regeneration in distant tissues
Serivichyaswat, P. T.; Bartusch, K.; Leso, M.; Musseau, C.; Iwase, A.; Chen, Y.; Sugimoto, K.; Quint, M.; Melnyk, C. W.
10.1101/2021.08.03.454483 — plant biology — Posted on 2021-08-03
3735 N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease.
Shewell, L. K.; Day, C. J.; Kutasovic, J. R.; Abrahams, J. L.; Wang, J.; Poole, J.; Niland, C.; Ferguson, K.; Saunus, J. M.; Lakhani, S. R.; Itzstein, M. v.; Paton, J. C.; Paton, A. W.; Jennings, M. P.
10.1101/2021.06.21.449179 — cancer biology — Posted on 2021-08-03
3737 Rabies virus with a destabilization domain added to its nucleoprotein spreads between neurons only if the domain is removed
Jin, L.; Matsuyama, M.; Sullivan, H. A.; Zhu, M.; Lavin, T. K.; Hou, Y.; Lea, N. E.; Pruner, M. T.; Dam Ferdinez, M. L.; Wickersham, I. R.
10.1101/550640 — neuroscience — Posted on 2021-08-03
3743 The novel leishmanial Copper P-type ATPase plays a vital role in intracellular parasite survival
Paul, R.; Banerjee, S.; Sen, S.; Dubey, P.; Maji, S.; Bachhawat, A. K.; Datta, R.; Gupta, A.
10.1101/2021.01.01.425060 — cell biology — Posted on 2021-08-03
3744 Novel compound inhibitors of HIV-1NL4-3 Vpu
Robinson, C. A.; Lyddon, T. D.; Gil, H. M.; Evans, D. T.; Kuzmichev, Y. V.; Richard, J.; Finzi, A.; Welbourn, S.; Rasmussen, L.; Nebane, N. M.; Gupta, V. V.; Ananthan, S.; Cai, Z.; Wonderlich, E. R.; Augelli-Szafran, C.; Bostwick, R.; Ptak, R. G.; Schader, S.; Johnson, M. C.
10.1101/2021.07.30.454560 — microbiology — Posted on 2021-08-03
3745 Ruminant-associated Listeria monocytogenes isolates belong preferentially to dairy-related hypervirulent clones: a longitudinal study in 19 farms
Palacios-Gorba, C.; MOURA, A.; Gomis, J.; Leclercq, A.; Gomez-Martin, A.; Bracq-Dieye, H.; Moce, M. L.; TESSAUD-RITA, N.; Jimenez-Trigos, E.; VALES, G.; Garcia-Munoz, A.; THOUVENOT, P.; Garcia-Rosello, E.; Lecuit, M.; Quereda, J. J.
10.1101/2021.07.29.454412 — microbiology — Posted on 2021-08-03
3746 Circulating immune complexes drive immunopathology in COVID-19
Ankerhold, J.; Giese, S.; Kolb, P.; Maul-Pavicic, A.; Goeppert, N.; Ciminski, K.; Kreutz, C.; Lother, A.; Salzer, U.; Bildl, W.; Welsink, T.; Morgenthaler, N.; Busse Grawitz, A.; Huzly, D.; Schwemmle, M.; Hengel, H.; Falcone, V.
10.1101/2021.06.25.449893 — immunology — Posted on 2021-08-03
3747 Investigating the Contribution of White Matter Hyperintensities and Cortical Thickness to Empathy in Neurodegenerative and Cerebrovascular Diseases
Ozzoude, M.; Varriano, B.; Beaton, D.; Ramirez, J.; Holmes, M. F.; Scott, C. J. M.; Gao, F.; Sunderland, K. M.; McLaughlin, P.; Rabin, J.; Goubran, M.; Kwan, D.; Roberts, A.; Bartha, R.; Symons, S.; Tan, B.; Swartz, R. H.; Abrahao, A.; Saposnik, G.; Masellis, M.; Lang, A. E.; Marras, C.; Zinman, L.; Shoesmith, C.; Borrie, M.; Fischer, C. E.; Frank, A.; Freedman, M.; Montero-Odasso, M.; Kumar, S.; Pasternak, S.; Strother, S. C.; Pollock, B. G.; Rajji, T. K.; Seitz, D.; Tang-wai, D.; Chum, M.; Turnbull, J.; Dowlatshahi, D.; Hassan, A.; Casaubon, L.; Mandzia, J.; Sahlas, D.; Breen, D. P.; Grimes,
10.1101/2021.08.01.454640 — neuroscience — Posted on 2021-08-03
3749 Subcortical brain segmentation in 5-year-old children: validation of FSL-FIRST and FreeSurfer against manual segmentation
Lidauer, K.; Pulli, E. P.; Copeland, A.; Silver, E.; Kumpulainen, V.; Hashempour, N.; Merisaari, H.; Saunavaara, J.; Parkkola, R.; Lahdesmaki, T.; Saukko, E.; Nolvi, S.; Kataja, E.-L.; Karlsson, L.; Karlsson, H.; Tuulari, J. J.
10.1101/2021.05.28.445926 — neuroscience — Posted on 2021-08-03
3750 PEERS - an open science "Platform for the Exchange of Experimental Research Standards" in biomedicine
Sil, A.; Bespalov, A.; Dalla, C.; Ferland-Beckham, C.; Herremans, A.; Karantzalos, K.; Kas, M. J.; Kokras, N.; Parnham, M. J.; Pavlidi, P.; Pristouris, K.; Steckler, T.; Riedel, G.; Emmerich, C. H.
10.1101/2021.07.31.454443 — scientific communication and education — Posted on 2021-08-03
3751 Arabidopsis Mediator subunit 17 connects transcription with DNA repair after UV-B exposure
Giustozzi, M.; Freytes, S.; Jaskolowski, A.; Lichy, M.; Mateos, J. L.; Falcone Ferreyra, M. L.; Rosano, G. L.; Cerdan, P. D.; Casati, P.
10.1101/2021.08.02.454780 — plant biology — Posted on 2021-08-03
3752 Cancer-associated fibroblasts exert a pro-angiogenic activity in Merkel cell carcinoma
Albertini, S.; Martuscelli, L.; Borgogna, C.; Virdi, S.; Indenbirken, D.; Lo Cigno, I.; Griffante, G.; Calati, F.; Boldorini, R. L.; Fischer, N.; Gariglio, M.
10.1101/2021.07.30.454425 — cancer biology — Posted on 2021-08-03
3753 A mechanosensing mechanism mediated by IRSp53 controls plasma membrane shape homeostasis at the nanoscale
Quiroga, X.; Walani, N.; Chavero, A.; Mittens, A.; Disanza, A.; Tebar, F.; Trepat, X.; Parton, R. G.; Scita, G.; Geli, M. I.; Arroyo, M.; Le Roux, A.-L.; Pere Roca-Cusachs, P.
10.1101/2021.08.01.454667 — biophysics — Posted on 2021-08-03
3756 Analysis of Preplatelets and Their Barbell Platelet Derivatives by Imaging Flow Cytometry
Kemble, S.; Dalby, A. L.; Lowe, G. C.; Nicolson, P. L.; Watson, S. P.; Senis, Y. A.; Thomas, S. G.; Harrison, P.
10.1101/2021.07.30.454421 — cell biology — Posted on 2021-08-03
3760 Eelbrain: A Python toolkit for time-continuous analysis with temporal response functions
Brodbeck, C.; Das, P.; Kulasingham, J. P.; Bhattasali, S.; Gaston, P.; Resnik, P.; Simon, J. Z.
10.1101/2021.08.01.454687 — neuroscience — Posted on 2021-08-03
3761 OPT3 plays a central role in both copper and iron homeostasis and signaling due to its ability to deliver copper as well as iron to the phloem in Arabidopsis
Vatamaniuk, O. K.; Chia, J.-C.; Yan, J.; Rahmati Ishka, M.; Faulkner, M. M.; Huang, R.; Smieska, L. M.; Woll, A. R.; Tappero, R. V.; Kiss, A.; Jiao, C.; Fei, Z.; Pineros, M. A.; Kochian, L. V.; Walker, E. L.
10.1101/2021.07.30.454504 — plant biology — Posted on 2021-08-03
3762 Using Obviously-Related Instrumental Variables to Increase the Predictive Power of Polygenic Scores
van Kippersluis, H.; Biroli, P.; Galama, T. J.; von Hinke, S.; Meddens, S. F. W.; Muslimova, D.; Pereira, R.; Rietveld, C. A.
10.1101/2021.04.09.439157 — genetics — Posted on 2021-08-03
3763 Beneficial effects of novel strains of Aureobasidium pullulans produced 1,3-1,6 β-glucans on non-esterified fatty acid levels in diabetic KKAy mice
Ikewaki, N.; Onaka, T.; Ikeue, Y.; Nagataki, M.; Kurosawa, G.; Dedeepiya, V. D.; Rajmohan, M.; Vaddi, S.; Senthilkumar, R.; Preethy, S.; Abraham, S. J.
10.1101/2021.07.22.453362 — pharmacology and toxicology — Posted on 2021-08-03
3766 Microvesicles Transfer Mitochondria and Increase Mitochondrial Function in Brain Endothelial Cells
D'Souza, A.; Burch, A.; Dave, K. M.; Sreeram, A.; Reynolds, M. S.; Dobbins, D. X.; Kamte, Y. S.; Zhao, W.; Sabatelle, C.; Joy, G. M.; Soman, V.; Chandran, U. R.; Shiva, S.; Quillinan, N.; Herson, P. S.; S Manickam, D.
10.1101/2021.04.10.439214 — bioengineering — Posted on 2021-08-02
3770 Genome-Wide Detection of Imprinted Differentially Methylated Regions Using Nanopore Sequencing
Akbari, V.; Garant, J.-M.; O'Neill, K.; Pandoh, P.; Moore, R.; Marra, M. A.; Hirst, M.; Jones, S. J.
10.1101/2021.07.17.452734 — genomics — Posted on 2021-08-02
3771 A locus conferring tolerance to Theileria infection in African cattle
Wragg, D.; Cook, E. A. J.; Latre de Late, P.; Sitt, T.; Hemmink, J. D.; Chepkwony, M.; Njeru, R.; Poole, E. J.; Powell, J.; Paxton, E.; Callaby, R.; Talenti, A.; Miyunga, A. A.; Ndambuki, G.; Mwaura, S.; Auty, H.; Matika, O.; Hassan, M. A.; Marshall, K.; Connelley, T. K.; Morrison, L.; Bronsvoort, B. M.; Morrison, W. I.; Toye, P.; Prendergast, J. G.
10.1101/2021.07.26.453771 — genetics — Posted on 2021-08-02
3776 Rapid Directed Molecular Evolution of Fluorescent Proteins in Mammalian Cells
Piatkevich, K. D.; Babakhanova, S.; Jung, E.; Namikawa, K.; ZHANG, H.; Subach, O.; Korzhenevskiy, D.; Rakitina, T.; Xiao, X.; Wang, W.; Shi, J.; Drobizhev, M.; Park, D.; Eisenhard, L.; Tang, H.; Koster, R.; Subach, F.; Boyden, E.
10.1101/2021.08.02.454744 — molecular biology — Posted on 2021-08-02
3777 Genome-wide RNA structure changes during human neurogenesis drive gene regulatory networks
Wang, J.; Zhang, T.; Zhang, Y.; Tan, W. T.; Huber, R. G.; LAMBERT, F.; ming, w.; Shen, Y.; Wan, Y.
10.1101/2021.08.02.454835 — molecular biology — Posted on 2021-08-02
3778 Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice.
Alvarado, D. M.; Son, J.; Thackray, L. B.; Diamond, M.; Ding, S.; Ciorba, M. A.; Washington University IBD Investigators Group,
10.1101/2021.07.23.453393 — microbiology — Posted on 2021-08-02
3779 Limited Phylogenetic Overlap Between Fluoroquinolone-Resistant Escherichia coli Isolated on Dairy Farms and those Causing Bacteriuria in Humans Living in the Same Geographical Region
Mounsey, O.; Schubert, H.; Findlay, J.; Morley, K.; Puddy, E. F.; Gould, V. C.; North, P.; Bowker, K. E.; Williams, M.; Williams, P. B.; Barrett, D. C.; Cogan, T. A.; Turner, K. M.; MacGowan, A. P.; Reyher, K. K.; Avison, M. B.
10.1101/2021.04.24.441264 — microbiology — Posted on 2021-08-02
3781 Sustained post-developmental T-bet expression is critical for the maintenance of type 1 innate lymphoid cells in vivo
Schroeder, J.-H.; Roberts, L. B.; Meissl, K.; Lo, J. W.; Hromadova, D.; Hayes, K.; Zabinski, T.; Read, E.; Moreira Heliodoro, C.; Reis, R.; Howard, J. K.; Grencis, R. K.; Neves, J. F.; Strobl, B.; Lord, G. M.
10.1101/2021.06.05.447200 — immunology — Posted on 2021-08-02
3782 SYNAPTIC RELEASE POTENTIATION AT AGING AUDITORY RIBBON SYNAPSES
Peineau, T.; Belleudy, S.; Pietropaolo, S.; Bouleau, Y.; Dulon, D.
10.1101/2020.05.15.097550 — neuroscience — Posted on 2021-08-02
3783 Hippocampal replay of experience at real-world speeds
Denovellis, E. L.; Gillespie, A. K.; Coulter, M. E.; Sosa, M.; Chung, J. E.; Eden, U. T.; Frank, L. M.
10.1101/2020.10.20.347708 — neuroscience — Posted on 2021-08-02
3788 tdLanYFP, a yellow, bright, photostable and pH insensitive fluorescent protein for live cell imaging and FRET-based sensing strategies
Bousmah, Y.; Valenta, H.; Bertolin, G.; Singh, U.; Nicolas, V.; Pasquier, H.; Tramier, M.; Merola, F.; Erard, M.
10.1101/2021.04.27.441613 — biophysics — Posted on 2021-08-02
3791 LanceOtron: a deep learning peak caller for ATAC-seq, ChIP-seq, and DNase-seq
Hentges, L. D.; Sergeant, M. D.; Downes, D. J.; Hughes, J. R.; Taylor, S.
10.1101/2021.01.25.428108 — bioinformatics — Posted on 2021-08-02
3793 Multi-run Concrete Autoencoder to Identify Prognostic lncRNAs for 12 Cancers
Al Mamun, A.; Tanvir, R. B.; Sobhan, M.; Mathee, K.; Narasimhan, G.; Holt, G. E.; Mondal, A. M.
10.1101/2021.08.01.454691 — bioinformatics — Posted on 2021-08-02
3794 Genetic basis of a spontaneous mutation's expressivity
Schell, R.; Hale, J. J.; Mullis, M. N.; Matsui, T.; Foree, R.; Ehrenreich, I. M.
10.1101/2020.04.03.024547 — genetics — Posted on 2021-08-02
3797 Mouse CHD4-NURD is required for spermatogonia survival and normal meiotic progression
de Castro, R. O.; Onate-Colobon, P.; Previato, L.; Carbajal, A.; Goitea, V.; Griffin, C.; Pezza, R.
10.1101/687137 — developmental biology — Posted on 2021-08-02
3800 Lipid droplets regulate actin remodeling via prostaglandin signaling during Drosophila oogenesis
Giedt, M. S.; Thomalla, J. M.; Johnson, M. R.; Lai, Z. W.; Tootle, T. L.; Welte, M. A.
10.1101/2021.08.02.454724 — cell biology — Posted on 2021-08-02
3801 ATP-responsive biomolecular condensates tune bacterial kinase signaling
Saurabh, S.; Chong, T. N.; Bayas, C.; Dahlberg, P. D.; Cartwright, H. N.; Moerner, W. E.; Shapiro, L.
10.1101/2020.08.09.232405 — microbiology — Posted on 2021-08-02
3804 The CHK-2 antagonizing phosphatase PPM-1.D regulates meiotic entry via catalytic and non-catalytic activities
Baudrimont, A.; Paouneskou, D.; Mohammad, A.; Lichtenberger, R.; Blundon, J.; Kim, Y.; Hartl, M.; Falk, S.; Schedl, T.; Jantsch, V.
10.1101/2021.08.02.453806 — cell biology — Posted on 2021-08-02
3805 Transcriptomic analysis of pathways associated with alpha(v) integrin-related non-canonical autophagy in human B cells
Sagadiev, S.; Muir, V.; Suchland, E.; MEITLIS, I.; Giltiay, N.; Tam, J.; Garner, E. C.; Wivagg, C.; Shows, D.; James, R.; Lacy-Hulbert, A.; Acharya, M.
10.1101/2021.08.02.452710 — immunology — Posted on 2021-08-02
3806 Deploying photons for communication within neuronal networks
Porta-de-la-Riva, M.; Gonzalez, A. C.; Sanfeliu-Cerdan, N.; Karimi, S.; Gonzalez, S.; Morales-Curiel, L. F.; Hurth, C.; Krieg, M.
10.1101/2021.08.02.454613 — synthetic biology — Posted on 2021-08-02
3807 Colon epithelial cell-specific Bmal1 deletion impairs bone formation in mice
Ko, F. C.; Jochum, S. B.; Wilson, B. M.; Adra, A.; Patel, N.; Wilber, S.; Shaikh, M. W.; Forsyth, C.; Keshavarzian, A.; Swanson, G.; Sumner, D. R.
10.1101/2021.08.02.454190 — physiology — Posted on 2021-08-02
3808 Microbial community of recently discovered Auka vent field sheds light on vent biogeography and evolutionary history of thermophily
Speth, D. R.; Yu, F. B.; Connon, S. A.; Lim, S.; Magyar, J. S.; Pena, M. E.; Quake, S. R.; Orphan, V. J.
10.1101/2021.08.02.454472 — genomics — Posted on 2021-08-02
3811 Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells in the absence of transferrin
Gallego-Murillo, J. S.; Yagcı, N.; Pinho, E. M.; Abeijon-Valle, A.; Wahl, A.; van den Akker, E.; von Lindern, M.
10.1101/2021.08.02.454758 — cell biology — Posted on 2021-08-02
3814 Dissecting the import and export pathways of the human RNA helicase UPF1
Eberle, A. B.; Schranz, K.; Nasif, S.; Grollmus, L.; Muehlemann, O.
10.1101/2021.08.02.454737 — cell biology — Posted on 2021-08-02
3816 Genome-wide DNA methylation and multi-omics study of human chondrocyte ontogeny and an epigenetic clock analysis of adult chondrocytes
Sarkar, A.; Lee, S.; Shkhyan, R.; Liu, N. Q.; Van Handel, B.; Magallanes, J.; Lee, Y.; Tao, L.; Segil, N.; Ernst, J.; Horvath, S.; Evseenko, D.
10.1101/2021.08.02.454544 — molecular biology — Posted on 2021-08-02
3817 Small molecule photocatalysis enables drug target identification via energy transfer
Trowbridge, A. D.; Seath, C. P.; Rodriguez-Rivera, F. P.; Li, B. X.; Dul, B. E.; Schwaid, A. G.; Geri, J. B.; Oakley, J. V.; Fadeyi, O. O.; Oslund, R. C.; Ryu, K. A.; White, C.; Reyes-Robles, T.; Tawa, P.; Parker, D. L.; MacMillan, D. W. C.
10.1101/2021.08.02.454797 — molecular biology — Posted on 2021-08-02
3818 Involvement of translocon complex in hemoglobin import from infected erythrocyte cytoplasm into the Plasmodium parasite
Gupta, P.; Pandey, R.; Thakur, V.; Parveen, S.; Kaur, I.; Panda, A.; Bishi, R.; Mehrotra, S.; Gupta, D.; Mohmmed, A.; Malhotra, P.
10.1101/2021.08.02.454712 — molecular biology — Posted on 2021-08-02
3819 CRISPR/Cas9 screen for functional MYC binding sites reveals MYC-dependent vulnerabilities in K562 cells
Kazimierska, M.; Podralska, M.; Zurawek, M.; Wozniak, T.; Kasprzyk, M. E.; Sura, W.; Losiewski, W.; Ziolkowska-Suchanek, I.; Kluiver, J. L.; van den Berg, A.; Rozwadowska, N.; Dzikiewicz-Krawczyk, A.
10.1101/2021.08.02.454734 — molecular biology — Posted on 2021-08-02
3821 Nutrient limitation magnifies fitness costs of antimalarial drug resistance mutations
Nair, S. K.; Li, X.; Arya, G. A.; McDew-White, M.; Ferrari, M.; Anderson, T. J.
10.1101/2021.08.02.454586 — microbiology — Posted on 2021-08-02
3825 Unique features of magic spot metabolism in Clostridioides difficile
Poudel, A.; Pokhrel, A.; Oludiran, A.; Coronado, E. J.; Alleyne, K.; Gilfus, M. M.; Gurung, R. K.; Adhikari, S. B.; Purcell, E. B.
10.1101/2021.08.02.454818 — microbiology — Posted on 2021-08-02
3826 Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses
Hume, A. J.; Heiden, B.; Olejnik, J.; Suder, E. L.; Ross, S.; Scoon, W. A.; Bullitt, E.; Ericsson, M.; White, M. R.; Turcinovic, J.; Thao, T. T. N.; Hekman, R. M.; Kaserman, J. E.; Huang, J.; Alysandratos, K.; Toth, G. E.; Jakab, F.; Kotton, D. N.; Wilson, A. A.; Emili, A.; Thiel, V.; Connor, J. H.; Kemenesi, G.; Cifuentes, D.; Mühlberger, E.
10.1101/2021.08.02.454777 — microbiology — Posted on 2021-08-02
3829 SARS-CoV-2 Alpha, Beta and Delta variants display enhanced Spike-mediated Syncytia Formation
Rajah, M. M.; Hubert, M.; Bishop, E.; Saunders, N.; Robinot, R.; Grzelak, L.; Planas, D.; Dufloo, J.; Gellenoncourt, S.; Bongers, A.; Zivaljic, M.; Planchais, C.; Guivel-Benhassine, F.; Porrot, F.; Mouquet, H.; Chakrabarti, L.; Buchrieser, J.; Schwartz, O.
10.1101/2021.06.11.448011 — microbiology — Posted on 2021-08-02
3830 SARS-CoV-2 fears green: the chlorophyll catabolite Pheophorbide a is a potent antiviral
Jimenez-Aleman, G. H.; Castro, V.; Longdaitsbehere, A.; Gutierrez-Rodriguez, M.; Garaigorta, U.; Gastaminza, P.; Solano, R.
10.1101/2021.07.31.454592 — molecular biology — Posted on 2021-08-02
3832 The maize E3 ligase ZmCER9 specifically targets activated NLRs for degradation
Karre, S.; Kim, S.-B.; Selote, D.; Khangura, R.; Dilkes, B.; Johal, G. S.; Balint-Kurti, P.
10.1101/2021.05.03.442530 — plant biology — Posted on 2021-08-02
3834 Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein
Tan, Z. W.; Tee, W.-V.; Samsudin, F.; Guarnera, E.; Bond, P. J.; Berezovsky, I. N.
10.1101/2021.08.01.454696 — bioinformatics — Posted on 2021-08-02
3838 Development and Characterization of PAR-Trackers: New Tools for Detecting Poly(ADP-ribose)
Kraus, W. L.; Challa, S.; Ryu, K. W.; Whitaker, A. L.; Abshier, J. C.; Camacho, C. V.
10.1101/2021.08.02.454729 — synthetic biology — Posted on 2021-08-02
3842 Classification and clustering of RNA crosslink-ligation data reveal complex structures and homodimers
Zhang, M.; Fischer-Hwang, I. T.; Li, K.; Bai, J.; Chen, J.-F.; Weismann, T.; Zou, J. Y.; Lu, Z.
10.1101/2021.08.01.454689 — bioinformatics — Posted on 2021-08-02
3843 Multi-run Concrete Autoencoder to Identify Prognostic lncRNAs for 12 Cancers
Al Mamun, A.; Tanvir, R. B.; Sobhan, M.; Mathee, K.; Narasimhan, G.; Holt, G. E.; Mondal, A. M.
10.1101/2021.08.01.454691 — bioinformatics — Posted on 2021-08-02
3844 Genome-wide protein-DNA interaction site mapping using a double strand DNA-specific cytosine deaminase
Gallagher, L. A.; Velazquez, E.; Peterson, S. B.; Charity, J. C.; Hsu, F.; Radey, M. C.; Gebhardt, M. J.; de Moraes, M. H.; Penewit, K. M.; Kim, J.; Andrade, P. A.; LaFramboise, T.; Salipante, S. J.; de Lorenzo, V.; Wiggins, P. A.; Dove, S. L.; Mougous, J.
10.1101/2021.08.01.454665 — genetics — Posted on 2021-08-02
3845 Both consumptive and non-consumptive effects of predators impact mosquito populations and have implications for disease transmission
Russell, M. C.; Herzog, C. M.; Gajewski, Z.; Ramsay, C.; El Moustaid, F.; Evans, M. V.; Desai, T.; Gottdenker, N.; Hermann, S.; Power, A. G.; McCall, A. C.
10.1101/2021.07.31.454599 — ecology — Posted on 2021-08-02
3847 Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model
Sutharsan, R.; Chen, L.; Lee, J. L.; Cruz, E.; Palliyaguru, T.; Leinenga, G.; Götz, J.
10.1101/2021.08.01.454692 — neuroscience — Posted on 2021-08-02
3848 On the discovery of ADRAM, an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3
Li, X.; Zhao, Q.; Wang, Z.; Liau, W.-S.; Basic, D.; Ren, H.; Marshall, P.; Zjaczkowski, E.; Leighton, L.; Madugalle, S.; Musgrove, M.; Periyakaruppiah, A.; Shi, J.; Zhang, J.; Mattick, J.; Mercer, T.; Wei, W.; Bredy, T.
10.1101/2021.08.01.454607 — neuroscience — Posted on 2021-08-02
3854 Hidden in the deep: distinct benthic trajectories call for monitoring of mesophotic reefs
Hernandez-Agreda, A.; Sahit, F. M.; Englebert, N.; Hoegh-Guldberg, O.; Bongaerts, P.
10.1101/2021.08.01.454664 — ecology — Posted on 2021-08-02
3856 Ectopic cervical thymi and no thymic involution until midlife in naked mole-rats
Emmrich, S.; Tolibzoda Zakusilo, F.; Trapp, A.; Zhou, X.; Zhang, Q.; Irving, E. M.; Drage, M. G.; Zhang, Z.; Gladyshev, V. N.; Seluanov, A.; Gorbunova, V.
10.1101/2021.08.01.454657 — immunology — Posted on 2021-08-02
3858 Adult neuromarkers of sustained attention and working memory predict inter- and intra-individual differences in these processes in youth
Kardan, O.; Stier, A. J.; Cardenas-Inigues, C.; Pruin, J. C.; Schertz, K. E.; Deng, Y.; Chamberlain, T.; Meredith, W. J.; Zhang, X.; Bowman, J. E.; Lakhtakia, T.; Tindel, L.; Avery, E. W.; Lin, Q.; Yoo, K.; Chun, M. M.; Berman, M. G.; Rosenberg, M. D.
10.1101/2021.08.01.454530 — neuroscience — Posted on 2021-08-02
3860 Validation of non-invasive body-surface gastric mapping for detecting electrophysiological biomarkers by simultaneous high-resolution serosal mapping in a porcine model
Calder, S.; Cheng, L. K.; Andrews, C.; Paskaranandavadivel, N.; Waite, S.; Alighaleh, S.; Erickson, J.; Gharibans, A.; O'Grady, G.; Du, P.
10.1101/2021.08.01.454685 — physiology — Posted on 2021-08-02
3862 Mixed Effects Machine Learning Models for Colon Cancer Metastasis Prediction using Spatially Localized Immuno-Oncology Markers
Levy, J.; Bobak, C.; Nasir-Moin, M.; Veziroglu, E. M.; Palisoul, S. M.; Barney, R. E.; Salas, L. A.; Christensen, B. C.; Tsongalis, G. J.; Vaickus, L. J.
10.1101/2021.08.01.454649 — pathology — Posted on 2021-08-02
3863 Harnessing protein folding neural networks for peptide-protein docking
Tsaban, T.; Varga, J. K.; Avraham, O.; Ben Aharon, Z.; Khramushin, A.; Schueler-Furman, O.
10.1101/2021.08.01.454656 — bioinformatics — Posted on 2021-08-02
3864 Scalable Clustering with Supervised Linkage Methods
Anibal, J.; Day, A.; Bahadiroglu, E.; O'Neill, L.; Phan, L.; Peltekian, A.; Erez, A.; Kaplan, M.; Altan-Bonnet, G.; Mehta, P.
10.1101/2021.08.01.454697 — bioinformatics — Posted on 2021-08-02
3870 The beneficial rhizobacterium Bacillus velezensis acquires iron from roots via a type VII secretion system for colonization
Liu, Y.; Shu, X.; Chen, L.; Zhang, H.; Feng, H.; Sun, X.; Xiong, Q.; Li, G.; Xun, W.; Xu, Z.; Zhang, N.; Pieterse, C. M. J.; Shen, Q.; Zhang, R.
10.1101/2021.08.01.454677 — microbiology — Posted on 2021-08-02
3871 Label-free monitoring of 3D cortical neuronal growth in vitro using optical diffraction tomography
Lee, A. J.; Yoon, D.; Han, S.; Hugonnet, H.; Park, W.; Park, J.-K.; Nam, Y.; Park, Y.
10.1101/2021.07.31.454602 — neuroscience — Posted on 2021-08-02
3874 High-fidelity, high-spatial-resolution diffusion MRI of the ex-vivo whole human brain on the 3T Connectom scanner using structured low-rank EPI ghost correction
Ramos-Llorden, G.; Lobos, R.; Kim, T. H.; Tian, Q.; Witzel, T.; Lee, H.-H.; Scholz, A.; Keil, B.; Yendiki, A.; Bilgic, B.; Haldar, J. P.; Huang, S. Y.
10.1101/2021.08.01.454635 — neuroscience — Posted on 2021-08-02
3876 Fillable and Unfillable Gaps in Rice Transcriptome under Field and Controlled Environments
Hashida, Y.; Tezuka, A.; Nomura, Y.; Kamitani, M.; Kashima, M.; Kurita, Y.; Nagano, A. J.
10.1101/2021.07.31.454577 — plant biology — Posted on 2021-08-02
3879 HIV-1 drug resistance profiling using amino acid sequence space cartography
Pikalyova, K.; Orlov, A.; Lin, A.; Tarasova, O.; Marcou, G.; Horvath, D.; Poroikov, V.; Varnek, A.
10.1101/2021.07.31.454569 — bioinformatics — Posted on 2021-08-02
3882 DESIGNER DNA HYDROGELS TO STIMULATE 3D CELL INVASION BY ENHANCED RECEPTOR EXPRESSION AND MEMBRANE ENDOCYTOSIS
Walia, S.; Morya, V.; Gangrade, A.; Naskar, S.; Guduru, A.; Dalvi, S.; Maiti, P. K.; Ghoroi, C.; Bhatia, D. D.
10.1101/2021.07.31.454582 — bioengineering — Posted on 2021-08-02
3883 Large differences in carbohydrate degradation and transport potential in the genomes of lichen fungal symbionts
Resl, P.; Bujold, A. R.; Tagirdzhanova, G.; Meidl, P.; Freire Rallo, S.; Kono, M.; Fernandez-Brime, S.; Guthmundsson, H.; Andresson, O. S.; Muggia, L.; Mayrhofer, H.; McCutcheon, J.; Wedin, M.; Werth, S.; Willis, L. M.; Spribille, T.
10.1101/2021.08.01.454614 — genomics — Posted on 2021-08-02
3886 Within-Arctic horizontal gene transfer as a driver of convergent evolution in distantly related microalgae
Dorrell, R. G.; Kuo, A.; Fussy, Z.; Richardson, E. H.; Salamov, A.; Zarevski, N.; Freyria, N. J.; Ibarbalz, F. M.; Jenkins, J.; Pierella Karlusich, J. J.; Stecca Steindorff, A.; Edgar, R. E.; Handley, L.; Lail, K.; Lipzen, A.; Lombard, V.; McFarlane, J.; Nef, C.; Novak Vanclova, A. M.; Peng, Y.; Plott, C.; Potvin, M.; Vieira, F. R.; Barry, K. W.; Dacks, J. B.; de Vargas, C.; Henrissat, B.; Pelletier, E.; Schmutz, J.; Wincker, P.; Bowler, C.; Grigoriev, I. V.; Lovejoy, C.
10.1101/2021.07.31.454568 — evolutionary biology — Posted on 2021-08-02
3889 Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer's disease
Depp, C.; Sun, T.; Sasmita, A. O.; Spieth, L.; Berghoff, S. A.; Steixner-Kumar, A. A.; Subramanian, S.; Möbius, W.; Göbbels, S.; Saher, G.; Zampar, S.; Wirths, O.; Thalmann, M.; Saito, T.; Saido, T.; Krueger-Burg, D.; Kawaguchi, R.; Willem, M.; Haass, C.; Geschwind, D.; Ehrenreich, H.; Stassart, R.; Nave, K.-A.
10.1101/2021.07.31.454562 — neuroscience — Posted on 2021-08-02
3892 Egg size variation in a long-lived polyandrous shorebird in the context of senescence and breeding phenology
Eberhart-Hertel, L. J.; Falcao Rodrigues, L.; Krietsch, J.; Eberhart-Hertel, A. G.; Cruz-Lopez, M.; Vazquez-Rojas, K. A.; Gonzalez-Medina, E.; Schroeder, J.; Kuepper, C.
10.1101/2021.07.21.453188 — evolutionary biology — Posted on 2021-08-02
3893 Egg size variation in a long-lived polyandrous shorebird in the context of senescence and breeding phenology
Eberhart-Hertel, L. J.; Falcao Rodrigues, L.; Krietsch, J.; Eberhart-Hertel, A. G.; Cruz-Lopez, M.; Vazquez-Rojas, K. A.; Gonzalez-Medina, E.; Schroeder, J.; Küpper, C.
10.1101/2020.08.07.240150 — evolutionary biology — Posted on 2021-08-02
3894 Multi-omic Analysis of Developing Human Retina and Organoids Reveals Cell-Specific Cis-Regulatory Elements and Mechanisms of Non-Coding Genetic Disease Risk.
Thomas, E. D.; Timms, A. E.; Giles, S.; Harkins-Perry, S.; Lyu, P.; Hoang, T.; Qian, J.; Jackson, V.; Bahlo, M.; Blackshaw, S.; Friedlander, M.; Eade, K.; Cherry, T. J.
10.1101/2021.07.31.454254 — developmental biology — Posted on 2021-08-02
3897 Loss of C3aR induces immune infiltration and inflammatory microbiota in a novel spontaneous model of colon cancer
Krieg, C.; Weber, L. M.; Fosso, B.; Hardiman, G.; Mileti, E.; El Aidy, S.; Marzano, M.; Robinson, M. D.; Guglietta, S.
10.1101/2021.01.18.426963 — immunology — Posted on 2021-08-02
3905 Centromere formation remodels chromatin fibre structure
Naughton, C.; Huidobro, C.; Catacchio, C. R.; Buckle, A.; Grimes, G. R.; Nozawa, R.-S.; Purgato, S.; Rocchi, M.; Gilbert, N.
10.1101/2021.08.01.454615 — molecular biology — Posted on 2021-08-02
3906 Degrading intestinal DAF-2 nearly doubles Caenorhabditis elegans lifespan without affecting development or reproduction
Zhang, Y.-P.; Zhang, W.-H.; Zhang, P.; Li, Q.; Sun, Y.; Wang, J.-W.; Zhang, S.-B. O.; Cai, T.; Zhan, C.; Dong, M.-Q.
10.1101/2021.07.31.454567 — cell biology — Posted on 2021-08-02
3907 Postnatal SETD1B is essential for learning and the regulation of neuronal plasticity genes
Michurina, A.; Sakib, M. S.; Kerimoglu, C.; Krueger, D. M.; Kaurani, L.; Islam, M. R.; Devesh, J. P.; Schroeder, S.; Pena Centeno, T.; Zhou, J.; Pradhan, R.; Cha, J.; Xu, X.; Eichele, G.; Zeisberg, E. M.; Kranz, A.; Stewart, A. F.; Fischer, A.
10.1101/2021.08.02.454636 — neuroscience — Posted on 2021-08-02
3908 The gut bacteria of an invasive amphibian respond to the dual challenges of range-expansion and parasite attack
Zhou, J.; Nelson, T. M.; Rodriguez Lopez, C.; Zhou, S. J.; Ward-Fear, G.; Stuart, K. C.; Shine, R.; Rollins, L. A.
10.1101/2020.11.16.385690 — microbiology — Posted on 2021-08-02
3909 Can fMRI functional connectivity index dynamic neural communication?
Alonso Martinez, S.; Llera Arenas, A.; Ter Horst, G. T.; Vidaurre, D.
10.1101/2021.07.27.453965 — neuroscience — Posted on 2021-08-02
3912 FiCoS: a fine- and coarse-grained GPU-powered deterministic simulator for biochemical networks
Tangherloni, A.; Nobile, M. S.; Cazzaniga, P.; Capitoli, G.; Spolaor, S.; Rundo, L.; Mauri, G.; Besozzi, D.
10.1101/2021.01.15.426855 — systems biology — Posted on 2021-08-02
3916 Gene regulatory networks controlling temporal patterning, neurogenesis and cell fate specification in the mammalian retina.
Lyu, P.; Hoang, T.; Santiago, C. P.; Thomas, E.; Timms, A.; Appel, H.; Gimmen, M.; Le, N.; Jiang, L.; Kim, D. W.; Chen, S.; Espinoza, D.; Tegler, A.; Weir, K.; Clark, B.; Cherry, T. M.; Qian, J.; Blackshaw, S.
10.1101/2021.07.31.454200 — neuroscience — Posted on 2021-08-02
3917 The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs
Jackson, V.; Hermann, J.; Tynan, C. J.; Rolfe, D. J.; Corey, R. A.; Duncan, A. L.; Noriega, M.; Chu, A.; Kalli, A. C.; Jones, E. Y.; Sansom, M.; Martin-Fernandez, M. L.; Seiradake, E.; Chavent, M.
10.1101/2020.10.06.328401 — biophysics — Posted on 2021-08-02
3919 Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages
Gulay, K. C. M.; Aoshima, K.; Maekawa, N.; Konnai, S.; Kobayashi, A.; Kimura, T.
10.1101/2021.08.01.454679 — cancer biology — Posted on 2021-08-01
3920 Molecular dynamics simulation of a model brain membrane with and without a 14-3-3 tau protein
Contreras-Aburto, C.; Favela-Rosales, F.; Arvayo-Zatarain, J. A.; Reyes-Figueroa, A. D.; Castro-Villarreal, P.
10.1101/2021.07.31.454604 — biophysics — Posted on 2021-08-01
3925 Naked mole-rat hematopoietic stem and progenitors are highly quiescent with an inherent myeloid bias
Emmrich, S.; Trapp, A.; Tolibzoda Zakusilo, F.; Mariotti, M.; Straight, M. E.; Zhang, Z.; Gray, S.; Drage, M. G.; Ke, Z.; Takasugi, M.; Klusmann, J.-H.; Gladyshev, V. N.; Seluanov, A.; Gorbunova, V.
10.1101/2021.08.01.454652 — cell biology — Posted on 2021-08-01
3927 Epigenetic reprogramming of DCCs into dormancy suppresses metastasis via restored TGFβ-SMAD4 signaling.
Singh, D. K.; Farias, E.; Carcamo, S.; Hasson, D.; Sun, D.; Cheung, J.; Nobre, A. R.; Kale, N.; Sosa, M. S.; Bernstein, E.; Aguirre-Ghiso, J. A.
10.1101/2021.08.01.454684 — cancer biology — Posted on 2021-08-01
3928 Source tracking and global distribution of the mobilized tigecycline resistant gene tet(X)
Liu, Y.-H.; Zhang, R.-M.; Sun, J.; Sun, R.-Y.; Wang, M.-G.; Cui, C.-Y.; Fang, L.-X.; Liao, M.-n.; Lu, X.-q.; Liu, Y.; Liao, X.-P.
10.1101/2021.07.29.454411 — bioinformatics — Posted on 2021-08-01
3929 Plant-associated microbiomes promote nutrient turnover in impoverished substrates of a biodiversity hotspot
Camargo, A. P.; de Souza, R. S. C.; Jose, J.; Gerhardt, I. R.; Dante, R. A.; Mukherjee, S.; Huntemann, M.; Kyrpides, N. C.; Carazzolle, M. F.; Arruda, P.
10.1101/2021.07.30.454538 — genomics — Posted on 2021-08-01
3930 How do King Cobras move across a major highway? Unintentional wildlife crossing structures may facilitate movement.
Jones, M. D.; Marshall, B. M.; Smith, S. N.; Crane, M.; Silva, I.; Artchawakom, T.; Suwanwaree, P.; Waengsothorn, S.; Wuster, W.; Goode, M.; Strine, C. T.
10.1101/2021.07.30.454480 — ecology — Posted on 2021-08-01
3931 Interactive effects of microplastic pollution and heat stress on reef-building corals
Reichert, J.; Tirpitz, V.; Anand, R.; Bach, K.; Knopp, J.; Schubert, P.; Wilke, T.; Ziegler, M.
10.1101/2021.07.30.454458 — ecology — Posted on 2021-08-01
3932 Deep learning-enhanced morphological profiling predicts cell fate dynamics in real-time in hPSCs
Ren, E.; Kim, S.; Mohamad, S.; Huguet, S. F.; Shi, Y.; Cohen, A. R.; Piddini, E.; Carazo Salas, R. E.
10.1101/2021.07.31.454574 — cell biology — Posted on 2021-08-01
3933 STAT3 expression in dendritic cells protects mice from colitis by a gut microbiome-dependent mechanism
Liu, J.; Szilagyi, K.; Capitano, M.; Iyer, A. K.; He, J.; Olson, M.; Du, J.; Van Der Pol, W.; Morrow, C. D.; Zhou, B.; Kaplan, M.; Dent, A. L.; Brutkiewicz, R.
10.1101/2021.07.31.453520 — immunology — Posted on 2021-08-01
3934 Selective ablation of adult GFAP-expressing tanycytes leads to hypogonadotropic hypogonadism in males
BUTRUILLE, L.; BATAILLER, M.; CATEAU, M.-L.; SHARIF, A.; LEYSEN, V.; PREVOT, V.; VAUDIN, P.; PILLON, D.; MIGAUD, M.
10.1101/2021.07.31.454492 — neuroscience — Posted on 2021-08-01
3936 Identification of an isoflavonoid transporter required for the nodule establishment of the Rhizobium-Fabaceae symbiotic interaction
Biala-Leonhard, W.; Zanin, L.; Gottardi, S.; de Brito Francisco, R.; Venuti, S.; Valentinuzzi, F.; Mimmo, T.; Cesco, S.; Bassin, B.; Martinoia, E.; Pinton, R.; Jasinski, M.; Tomasi, N.
10.1101/2021.07.30.452494 — plant biology — Posted on 2021-08-01
3938 Chromosome-level Thlaspi arvense genome provides new tools for translational research and for a newly domesticated cash cover crop of the cooler climates
Nunn, A.; Rodriguez-Arevalo, I.; Tandukar, Z.; Frels, K.; Contreras-Garrido, A.; Carbonell-Bejerano, P.; Zhang, P.; Ramos-Cruz, D.; Jandrasits, K.; Lanz, C.; Brusa, A.; Mirouze, M.; Dorn, K.; Jarvis, B.; Sedbrook, J.; Wyse, D. L.; Otto, C.; Langenberger, D.; Stadler, P. F.; Weigel, D.; Marks, D.; Anderson, J. A.; Becker, C.; Chopra, R.
10.1101/2021.07.30.454478 — plant biology — Posted on 2021-08-01
3941 ALLSorts: a RNA-Seq classifier for B-Cell Acute Lymphoblastic Leukemia.
Schmidt, B. M.; Brown, L. M.; Ryland, G. L.; Lonsdale, A.; Kosasih, H. J.; Ludlow, L. E.; Majewski, I. J.; Blombery, P.; Ekert, P.; Davidson, N. M.; Oshlack, A.
10.1101/2021.08.01.454393 — bioinformatics — Posted on 2021-08-01
3942 In vitro evolution reveals primordial RNA-protein interaction mediated by metal cations
Giacobelli, V. G.; Fujishima, K.; Lepsik, M.; Tretyachenko, V.; Kadava, T.; Bednarova, L.; Novak, P.; Hlouchova, K.
10.1101/2021.08.01.454623 — biochemistry — Posted on 2021-08-01
3943 The pace of modern life, revisited
Sanderson, S.; Beausoleil, M.-O.; O'dea, R. E.; Wood, Z. T.; Correa, C.; Frankel, V.; Gorne, L. D.; Haines, G. E.; Kinnison, M. T.; Oke, K. B.; Pelletier, F.; Perez-Jvostov, F.; Reyes-Corral, W. D.; Ritchot, Y.; Sorbara, F.; Gotanda, K. M.; Hendry, A. P.
10.1101/2021.07.30.454364 — evolutionary biology — Posted on 2021-08-01
3944 EP300 (p300) mediated histone butyrylation is critical for adipogenesis
Kundu, T. K.; Bhattacharya, A.; Chatteerjee, S.; Bhaduri, U.; Singh, A. K.; Vasudevan, M.; Sashidhara, K. V.; Guha, R.; Natesh, N.
10.1101/2021.08.01.454641 — molecular biology — Posted on 2021-08-01
3946 Transcriptomic analysis of ribosome biogenesis and pre-rRNA processing during growth stress in Entamoeba histolytica
Naiyer, S.; Singh, S. S.; Kaur, D.; Singh, Y. P.; Mukherjee, A.; Bhattacharya, A.; Bhattacharya, S.
10.1101/2021.08.01.454488 — microbiology — Posted on 2021-08-01
3952 Scaffold modelling captures the structure-function-dynamics relationship in brain microcircuits
De Schepper, R. G.; Geminiani, A.; Masoli, S.; Rizza, M. F.; Antonietti, A.; Casellato, C.; D'Angelo, E. U.
10.1101/2021.07.30.454314 — neuroscience — Posted on 2021-08-01
3955 An age-depth model and revised stratigraphy of vertebrate-bearing units in Natural Trap Cave, Wyoming
Lovelace, D. M.; Redman, C. M.; Minckley, T. A.; Schubert, B. W.; Mahan, S.; Wood, J. R.; McGuire, J. L.; Laden, J.; Bitterman, K.; Heiniger, H.; Fenderson, L.; Cooper, A.; Mitchell, K.; Meachen, J. A.
10.1101/2021.07.30.454390 — paleontology — Posted on 2021-08-01
3957 From contigs to chromosomes: automatic Improvement of Long Read Assemblies (ILRA)
Ruiz, J. L.; Reimering, S.; Sanders, M.; Escobar-Prieto, J. D.; Brancucci, N. M. B.; Echeverry, D. F.; Abdi, A. I.; Marti, M.; Gomez-Diaz, E.; Otto, T. D.
10.1101/2021.07.30.454413 — bioinformatics — Posted on 2021-08-01
3960 Injury risk functions for the four primary knee ligaments
Nusia, J.; Xu, J. C.; Sjöblom, R.; Knälmann, J.; Linder, A.; Kleiven, S.
10.1101/2021.07.30.454445 — bioengineering — Posted on 2021-08-01
3969 Brain structure and function predict adherence to an exercise intervention in older adults
Morris, T. P.; Burzynska, A.; Voss, M.; Fanning, J.; Salerno, E. A.; Prakash, R.; Gothe, N. P.; Whitfield-Gabrieli, S.; Hillman, C. H.; McAuley, E.; Kramer, A. F.
10.1101/2021.07.30.454451 — neuroscience — Posted on 2021-08-01
3970 Hypertension drives microbial translocation and shifts in the fecal microbiome of non-human primates
Vemuri, R.; Ruggiero, A.; Whitfield, J. B.; Dugan, G. O.; Cline, M. J.; Block, M. R.; Guo, H.; Kavanagh, K.
10.1101/2021.07.30.454379 — pathology — Posted on 2021-08-01
3972 A new single-cell level R-index for EGFR-TKI resistance and survival prediction in LUAD
Liu, Z.; Xie, X.; Li, L.; Xie, L.; Gao, X.; Xia, X.; Deng, H.; Yang, Y.; Yang, M.; Chang, L.-P.; Yi, X.; He, Z.; Zhou, C.
10.1101/2021.07.30.454426 — bioinformatics — Posted on 2021-08-01
3974 Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants
Du, S.; Liu, P.; Zhang, Z.; Xiao, T.; Yasimayi, A.; Huang, W.; Wang, Y.; Cao, Y. R.; Xie, X. S.; Xiao, J.
10.1101/2021.07.30.454402 — biochemistry — Posted on 2021-08-01
3979 Selective logging shows no impact on the dietary breadth of the fawn leaf-nosed bat (Hipposideros cervinus)
Hemprich-Bennett, D. R.; Kemp, V. A.; Blackman, J.; Lewis, O. T.; Struebig, M. J.; Bernard, H.; Rossiter, S. J.; Clare, E. L.
10.1101/2021.07.30.453964 — ecology — Posted on 2021-08-01
3980 Evolutionary dynamics of indels in SARS-CoV-2 spike glycoprotein
Rao, R. S. P.; Ahsan, N.; Xu, C.; Su, L.; Verburgt, J.; Fornelli, L.; Kihara, D.; Xu, D.
10.1101/2021.07.30.454557 — bioinformatics — Posted on 2021-08-01
3981 Comparable neutralization of SARS-CoV-2 Delta AY.1 and Delta in individuals sera vaccinated with BBV152
Yadav, P. D.; Sahay, R. R.; Sapkal, G.; Nyayanit, D.; Shete, A.; Deshpande, G.; Patil, D.; Gupta, N.; Kumar, S.; Abraham, P.; Panda, S.; Bhargava, B.
10.1101/2021.07.30.454511 — molecular biology — Posted on 2021-08-01
3982 Multi-layered transcriptomic analyses reveal an immunological overlap between COVID-19 and hemophagocytic lymphohistiocytosis associated with disease severity
Schimke, L. F.; Marques, A. H.; Baiocchi, G. C.; Prado, C. A.; Fonseca, D. L.; Freire, P. P.; Placa, D. R.; Filgueira, I. S.; Salgado, R. C.; Jansen-Marques, G.; Oliveira, A. E.; Peron, J. P. S.; Barbuto, J. A. M.; Camara, N. O. S.; Calich, V. L.; Ochs, H. D.; Condino-Neto, A.; Overmyer, K. A.; Coon, J. J.; Balnis, J.; Jaitovich, A.; Schulte-Schrepping, J.; Ulas, T.; Schultze, J. L.; Nakaya, H. I.; Jurisica, I.; Marques, O. C.
10.1101/2021.07.30.454529 — immunology — Posted on 2021-08-01
3983 Spike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2
Brady, M.; Combs, A.; Venkatraman, C.; Solorzano, A.; Johnson, A.; McQuaid, C.; Rahman, A.; Leyva, H.; Kwok, W.-C. E.; Wood, R. W.; Deane, R.
10.1101/2021.07.30.454520 — neuroscience — Posted on 2021-08-01
3985 Non-linear frequency-dependence of neurovascular coupling in the cerebellar cortex implies vasodilation-vasoconstriction competition
Gagliano, G.; Monteverdi, A.; Casali, S.; Laforenza, U.; Gandini Wheeler-Kingshott, C. A. M.; D'Angelo, E.; Mapelli, L.
10.1101/2021.07.30.454430 — neuroscience — Posted on 2021-08-01
3986 Subcellular and regional localization of mRNA translation in midbrain dopamine neurons
Hobson, B. D.; Kong, L.; Angelo, M. F.; Lieberman, O. J.; Mosharov, E. V.; Herzog, E.; Sulzer, D.; Sims, P. A.
10.1101/2021.07.30.454065 — neuroscience — Posted on 2021-08-01
3987 Internet of Things Architecture for High Throughput Biology
Parks, D. F.; Voitiuk, K.; Geng, J.; Elliott, M. A. T.; Keefe, M. G.; Jung, E. A.; Robbins, A.; Baudin, P. V.; Ly, V. T.; Hawthorne, N.; Yong, D.; Sanso, S. E.; Rezaee, N.; Sevetson, J. L.; Seiler, S. T.; Currie, R.; Hengen, K. B.; Nowakowski, T. J.; Salama, S. R.; Teodorescu, M.; Haussler, D.
10.1101/2021.07.29.453595 — bioengineering — Posted on 2021-08-01
3988 CancerMIRNome: an interactive analysis and visualization database for miRNome profiles of human cancer
Li, R.; Qu, H.; Wang, S.; Chater, J. M.; Wang, X.; Cui, Y.; Yu, L.; Zhou, R.; Jia, Q.; Traband, R.; Wang, M.; Xie, W.; Yuan, D.; Zhu, J.; Zhong, W.-D.; Jia, Z.
10.1101/2020.10.04.325670 — bioinformatics — Posted on 2021-08-01