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Archive, 2022-12

2 Metformin antiproliferative activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cells
Verduci, I.; Cianci, F.; Cazzoli, R.; Cannavale, G.; Veronesi, M.; Balboni, B.; Ranucci, M.; Palloni, L. M. G.; Richichi, C.; Faletti, S.; Osti, D.; Ailuno, G.; Caviglioli, G.; Tacconi, C.; GIROTTO, S.; Barbieri, F.; Fantin, A.; Cavalli, A.; Pelicci, G.; Florio, T.; Minucci, S.; Mazzanti, M.
10.1101/2022.12.31.522371 — cancer biology — Posted on 2022-12-31
6 Specificity, synergy, and mechanisms of splice-modifying drugs
Ishigami, Y.; Wong, M. S.; Marti-Gomez, C.; Ayaz, A.; Kooshkbaghi, M.; Hanson, S.; McCandlish, D. M.; Krainer, A. R.; Kinney, J. B.
10.1101/2022.12.30.522303 — biophysics — Posted on 2022-12-31
8 Annotating metabolite mass spectra with domain-inspired chemical formula transformers
Goldman, S.; Wohlwend, J.; Strazar, M.; Haroush, G.; Xavier, R. J.; Coley, C. W.
10.1101/2022.12.30.522318 — bioinformatics — Posted on 2022-12-31
10 An Autoinhibited Conformation of the DnaB-Replicative Helicase - phage {lambda}P Loader Complex
Brown, D.; Shatarupa, A.; Olinares, P. D.; Chase, J. D.; Isiorho, E.; Chait, B.; Jeruzalmi, D.
10.1101/2022.12.30.522210 — biochemistry — Posted on 2022-12-31
11 Intra- and inter-species interactions drive early phases of invasion in mice gut microbiota
Gencel, M.; Cofino, G. M.; Hui, C.; Sahaf, Z.; Gauthier, L.; Tsang, D.; Philpott, D.; Ramanathan, S.; Menendez, A.; Bershtein, S.; Serohijos, A.
10.1101/2022.12.30.522336 — evolutionary biology — Posted on 2022-12-31
13 Neuroendocrine control of catch-up growth in Drosophila
Vallejo, D. M.; Saez-Carrion, E.; Garcia-Lopez, L.; Santoro, R.; Dominguez, M.
10.1101/2022.12.30.522288 — developmental biology — Posted on 2022-12-31
15 Phages are important unrecognized players in the ecology of the oral pathogen Porphyromonas gingivalis
Matrishin, C. B.; Haase, E. M.; Dewhirst, F. E.; Mark Welch, J. L.; Miranda-Sanchez, F.; MacFarland, D. C.; Kauffman, K. M.
10.1101/2022.12.30.519816 — microbiology — Posted on 2022-12-31
18 Flexible and scalable control of T cell memory by a reversible epigenetic switch
Clark, E.; Abadie, K.; Ukogu, O.; Yang, W.; Daza, R.; Ng, K. K. H.; Fathima, J.; Wang, A.; Bhandoola, A.; Nourmohammad, A.; Shendure, J.; Cao, J.; Kueh, H. Y.
10.1101/2022.12.31.521782 — immunology — Posted on 2022-12-31
20 Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
De Vos, T.; Godar, M.; Bick, F.; Papageorgiou, A.; Evangelidis, T.; Markovic, I.; Mortier, E.; Dumoutier, L.; Tripsianes, K.; Blanchetot, C.; Savvides, S. N.
10.1101/2022.12.30.522308 — immunology — Posted on 2022-12-31
21 Traumatic brain injury induced microglial and Caspase3 activation in the retina
Kovacs-Oller, T.; Zempleni, R.; Balogh, B.; Szarka, G.; Fazekas, B.; Tengolics, A. J.; Amrein, K.; Czeiter, E.; Hernadi, I.; Buki, A.; Volgyi, B.
10.1101/2022.12.30.522345 — neuroscience — Posted on 2022-12-31
22 CLIP-Seq Analysis Enables the Design of Ribosomal RNA Bait Oligonucleotides That Protect Against C9orf72 ALS/FTD-Associated Poly-GR Pathophysiology
Ortega, J. A.; Sasselli, I. R.; Boccitto, M.; Fleming, A. C.; Fortuna, T. R.; Li, Y.; Sato, K.; Clemons, T. D.; Daley, E. L.; Nguyen, T. P.; Anderson, E. N.; Ichida, J.; Pandey, U. B.; Wolin, S.; Stupp, S. I.; Kiskinis, E.
10.1101/2022.12.30.522259 — neuroscience — Posted on 2022-12-31
23 A newly-recognized population of residual neural crest cells in the adult leptomeninges is re-activated for vascular repair
Nakamura, Y.; Nakano, T.; Park, J.-H.; Tanaka, M.; Li, W.; Esposito, E.; Ahn, B.-J.; Duran-Laforet, V.; Desai, R.; Sencan, I.; Sakadzic, S.; Lo, E.; Snyder, E.; Tabaka, M.; Hayakawa, K.
10.1101/2022.12.30.522316 — neuroscience — Posted on 2022-12-31
27 SARS-CoV-2 Protein Nsp2 Stimulates Translation Under Normal and Hypoxic Conditions
Korneeva, N.; Khalil, M. I.; Ghosh, i.; Fan, R.; Arnold, T.; De Benedetti, A.
10.1101/2022.09.13.507829 — physiology — Posted on 2022-12-31
28 Androgen-mediated TGFβ expression suppresses anti-tumor neutrophil response in bone metastatic prostate cancer
Cook, L. M.; Alsamraae, M.; Costanzo-Garvey, D.; Teply, B.; Sommerville, G.; Herbert, Z.; Morrissey, C.; Abdalla, M. Y.; Fallet, R. W.; Kielian, T.; Jensen-Smith, H.; deOliveira, E. I.; Chen, K.; Bettencourt, I.; Wang, J. M.; Keeley, T.; Yu, F.
10.1101/2022.12.30.522329 — cancer biology — Posted on 2022-12-31
30 Increased intracellular crowding during hyperosmotic stress
Kitamura, A.; Oasa, S.; Kawaguchi, H.; Osaka, M.; Vukojevic, V.; Kinjo, M.
10.1101/2022.12.30.522363 — biophysics — Posted on 2022-12-31
31 SAMBA: Structure-Learning of Aquaculture Microbiomes Using a Bayesian-Network Approach
Soriano, B.; Hafez, A.; Naya-Catala, F.; Moldovan, R. A.; Toxqui-Rodriguez, S.; Piazzon, M. C.; Arnau, V.; Llorens, C.; Perez-Sanchez, J.
10.1101/2022.12.30.522281 — bioinformatics — Posted on 2022-12-31
34 The ketone body acetoacetate activates human neutrophils through FFA2R
Martensson, J.; Bjorkman, L.; Lind, S.; Viklund, M.; Zhang, L.; Gutierrez, S.; Dahlgren, C.; Sundqvist, M.; Xie, X.; Forsman, H.
10.1101/2022.12.30.522309 — cell biology — Posted on 2022-12-31
35 Expanded tRNA methyltransferase family member TRMT9B regulates synaptic growth and function
Hogan, C. A.; Gratz, S. J.; Dumouchel, J. M.; Delgado, A.; Lentini, J. M.; Madhwani, K. R.; Thakur, R. S.; Fu, D.; O'Connor-Giles, K. M.
10.1101/2022.12.30.522321 — neuroscience — Posted on 2022-12-31
36 Neurological Disorder after Severe Pneumonia is Associated with Translocation of Bacteria from Lung to Brain
Ma, Q.; Yao, C.; Wu, Y.; Wang, H.; Fan, Q.; Yang, Q.; Xu, J.; Dai, H.; Zhang, Y.; Xu, F.; Lu, T.; Wang, C.
10.1101/2022.12.30.522351 — neuroscience — Posted on 2022-12-31
37 Simple Models For Neuroscience Research Discoveries: How Often Are These Models Used In Africa
Hamidu, S. k.; Ahmad, U.; Abdulazeez, R.; Zaid, M.; Alkhamis, A. I.; Umar, M.; Ladan, A. A.; Nasr, F. E.; Ahmad, A.; Musa, S.; Ya'u, J.; Hamman, W. O.; Yoshimatsu, T.; Issa, S. R.; Maina, M. B.
10.1101/2022.12.30.522314 — neuroscience — Posted on 2022-12-31
40 Systemic effects of melanoma-secreted MIDKINE in the inhibition of dendritic cell differentiation and function
Catena, X.; Contreras, M.; Cerezo-Wallis, D.; Larrea, N. J.; Olmeda, D.; Calvo, G. G.; Mucientes, C.; Oterino, S.; Soengas, M. S.
10.1101/2022.12.28.521901 — cancer biology — Posted on 2022-12-31
41 Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer
Feng, Y.; Newsome, R. C.; Robinson, T.; Bowman, R. L.; Zuniga, A. N.; Hall, K. N.; Berntsen, C. M.; Shabashvili, D. E.; Krajcik, K. I.; Gunaratne, C.; Zaroogian, Z. J.; Venugopal, K.; Casellas Roman, H. L.; Levine, R. L.; Chatila, W. K.; Yaeger, R.; Riva, A.; Kopinke, D.; Jobin, C.; Avram, D.; Guryanova, O. A.
10.1101/2022.12.30.522355 — cancer biology — Posted on 2022-12-31
42 StereoSiTE: A framework to spatially and quantitatively profile the cellular neighborhood organized iTME
Liu, X.; Qu, C.; Liu, C.; Zhu, N.; Huang, H.; Teng, F.; Huang, C.; Luo, B.; Liu, X.; Xu, Y.; Xie, M.; Xi, F.; Li, M.; Wu, L.; Li, Y.; Chen, A.; Xu, X.; Liao, S.; Zhang, J.
10.1101/2022.12.31.522366 — cancer biology — Posted on 2022-12-31
46 Novel lentiviral vectors for gene therapy of sickle cell disease combining gene addition and gene silencing strategies
Brusson, M.; Chalumeau, A.; Martinucci, P.; Romano, O.; Poletti, V.; Scaramuzza, S.; Ramadier, S.; Masson, C.; Ferrari, G.; Mavilio, F.; Cavazzana, M.; Amendola, M.; Miccio, A.
10.1101/2022.12.31.522279 — genetics — Posted on 2022-12-31
48 High Sensitivity Top-down Proteomics Captures Single Muscle Cell Heterogeneity in Large Proteoforms
Melby, J. A.; Brown, K. A.; Gregorich, Z. R.; Roberts, D. S.; Chapman, E. A.; Ehlers, L. E.; Gao, Z.; Larson, E. J.; Jin, Y.; Lopez, J.; Hartung, J.; Zhu, Y.; Wang, D.; Guo, W.; Diffee, G. M.; Ge, Y.
10.1101/2022.12.29.521273 — biochemistry — Posted on 2022-12-31
53 A thalamo-parietal cortex circuit is critical for place-action coordination
Simmons, C.; Moseley, S.; Ogg, J. D.; Johnson, M.; Clark, B. J.; Wilber, A.
10.1101/2022.12.30.522207 — neuroscience — Posted on 2022-12-31
54 Copy number variants alter local and global mutational tolerance
Avecilla, G.; Spealman, P.; Matthews, J.; Caudal, E.; Schacherer, J.; Gresham, D.
10.1101/2022.12.30.521611 — genetics — Posted on 2022-12-31
55 VEGF-C expressing Tumor-Associated Macrophages decrease hematogenous metastatic dissemination and normalizes the tumor vasculature
Ferreira, S. d. S.; Wallmann, T.; Kerzel, T.; Wallerius, M.; Landwehr, L. S.; Agardy, D. A.; Bergh, J.; Bartish, M.; Hartman, J.; Squadrito, M. L.; Rolny, C.
10.1101/2022.01.26.468593 — cancer biology — Posted on 2022-12-30
58 Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation
Meyers, A. K.; Wang, Z.; Han, W.; Zhao, Q.; Zabalawi, M.; Duan, L.; Liu, J.; Zhang, Q.; Manne, R. K.; Lorenzo, F.; Quinn, M. A.; Song, Q.; Fan, D.; Lin, H.-K.; Furdui, C. M.; Locasale, J. W.; McCall, C. M.; Zhu, X.
10.1101/2021.10.02.462869 — immunology — Posted on 2022-12-30
60 A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain
Chen, C. H.; Newman, L. N.; Stark, A. P.; Bond, K. E.; Zhang, D.; Nardone, S.; Vanderburg, C. R.; Nadaf, N. M.; Yao, Z.; Mutume, K.; Flaquer, I.; Lowell, B. B.; Macosko, E.; Regehr, W. G.
10.1101/2021.09.21.461236 — neuroscience — Posted on 2022-12-30
61 Inflammasome mediated neuronal-microglial crosstalk: a therapeutic substrate for the familial C9orf72 variant of the frontotemporal dementia/amyotrophic lateral sclerosis
Trageser, K. J.; Smith, C.; Yang, E.-J.; Iban Arias, R.; Oguchi, T.; Sebastian-Valverde, M.; Iqbal, U. H.; Wu, H.; Estill, M.; Al Rahim, M.; Raval, U.; Herman, F. J.; Zhang, Y.-J.; Petrucelli, L.; Pasinetti, G. M.
10.1101/2022.01.27.478078 — neuroscience — Posted on 2022-12-30
62 Homunculus Interruptus: A motor association area in the depth of the central sulcus
Jensen, M. A.; Huang, H.; Ojeda Valencia, G.; Klassen, B. T.; van den Boom, M. A.; Kaufmann, T. J.; Schalk, G.; Brunner, P.; Hermes, D.; Worrell, G. A.; Miller, K. J.
10.1101/2022.11.20.517292 — neuroscience — Posted on 2022-12-30
68 The shh limb enhancer is activated in patterned limb regeneration but not in hypomorphic limb regeneration in Xenopus laevis
Tada, R.; Higashidate, T.; Amano, T.; Ishikawa, S.; Yokoyama, C.; Nara, S.; Ishida, K.; Kawaguchi, A.; Ochi, H.; Ogino, H.; Yakushiji-Kaminatsui, N.; Sakamoto, J.; Kamei, Y.; Tamura, K.; Yokoyama, H.
10.1101/2022.12.27.522067 — developmental biology — Posted on 2022-12-30
69 MHC class I Ligands of Rhesus Macaque Killer-Cell Immunoglobulin-Like Receptors
Anderson, J. L.; Sandstrom, K.; Smith, W. R.; Wetzel, M.; Klenchin, V. A.; Evans, D. T.
10.1101/2022.05.25.493479 — immunology — Posted on 2022-12-30
70 The coarse mental map of the breast is anchored on the nipple
Long, K.; Fitzgerald, E.; Berger-Wolf, E.; Fawaz, A.; Greenspon, C.; Lindau, S.; Bensmaia, S. J.
10.1101/2022.09.14.507974 — neuroscience — Posted on 2022-12-30
73 Behavioral responses of free flying Drosophila melanogaster to shiny, reflecting surfaces
Mathejczyk, T. F.; Babo, E. J.; Schoenlein, E.; Grinda, N. V.; Greiner, A.; Okroznik, N.; Belusic, G.; Wernet, M. F.
10.1101/2022.12.30.522304 — animal behavior and cognition — Posted on 2022-12-30
74 Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology
Wang, Y.; Kanai, M.; Tan, T.; Kamariza, M.; Tsuo, K.; Yuan, K.; Zhou, W.; Okada, Y.; Huang, H.; Turley, P.; Atkinson, E. G.; Martin, A. R.
10.1101/2022.12.29.522270 — genomics — Posted on 2022-12-30
78 Interplay of EXO70 and MLO proteins modulates trichome cell wall composition and powdery mildew susceptibility
Huebbers, J. W.; Caldarescu, G. A.; Kubatova, Z.; Sabol, P.; Levecque, S. C. J.; Kuhn, H.; Kulich, I.; Reinstaedler, A.; Buettgen, K.; Manga-Robles, A.; Melida, H.; Pauly, M.; Panstruga, R.; Zarsky, V.
10.1101/2022.12.30.521597 — plant biology — Posted on 2022-12-30
80 Carcinogen induced expansion of atypical B cells and pre-treatment tumor adjacent tertiary lymphoid structures associate with poor response to BCG in non-muscle invasive bladder cancer
Yolmo, P.; Rahimi, S.; Chenard, S.; Conseil, G.; Jenkins, D.; Emon, I.; Hamilton, J.; Xu, M.; Rangachari, M.; Berman, D. M.; Siemens, D. R.; Koti, M.
10.1101/2022.12.30.522127 — cancer biology — Posted on 2022-12-30
85 Predicting regulators of epithelial cell state through regularized regression analysis of single cell multiomic sequencing
Ledru, N.; Wilson, P. C.; Muto, Y.; Yoshimura, Y.; Wu, H.; Asthana, A.; Tullius, S. G.; Waikar, S. S.; Orlando, G.; Humphreys, B.
10.1101/2022.12.29.522232 — genomics — Posted on 2022-12-30
87 Starvation sensing by mycobacterial RelA/SpoT homologue through constitutive surveillance of translation
Li, Y.; Majumdar, S.; Treen, R.; Sharma, M. R.; Corro, J.; Gamper, H.; Manjari, S. R.; Prusa, J.; Banavali, N. K.; Stallings, C. L.; Hou, Y.-M.; Agrawal, R. L.; Ojha, A. K.
10.1101/2022.12.29.522164 — molecular biology — Posted on 2022-12-30
88 The RBM17/SPF45-SAP30BP interaction is essential for splicing in a subset of human short introns
Fukumura, K.; Sperotto, L.; Seuss, S.; Kang, H.-S.; Yoshimoto, R.; Sattler, M.; Mayeda, A.
10.1101/2022.12.30.522300 — molecular biology — Posted on 2022-12-30
89 Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in Cryptococcus neoformans
Meng, Y.; Li, Z.; Jiang, T.; Sun, T.; Li, Y.; Gao, X.; Li, H.; Suo, C.; Li, C.; Yang, S.; Lan, T.; Liao, G.; Liu, T.-B.; Wang, P.; Ding, C.
10.1101/2022.12.30.522307 — microbiology — Posted on 2022-12-30
90 An integrated systems-biology platform for power-to-gas technology
Casini, I.; McCubbin, T.; Esquivel-Elizondo, S.; Luque, G. G.; Evseeva, D.; Fink, C.; Beblawy, S.; Youngblut, N. D.; Aristilde, L.; Huson, D.; Drager, A.; Ley, R.; Marcellin, E.; Angenent, L. T.; Molitor, B.
10.1101/2022.12.30.522236 — microbiology — Posted on 2022-12-30
91 Surveillance for SARS-CoV-2 in Ohio's wildlife, companion, and agricultural animals
Ehrlich, M.; Madden, C.; McBride, D.; Nolting, J. M.; Huey, D.; Kenney, S.; Wang, Q.; Saif, L.; Vlasova, A.; Dennis, P.; Lombardi, D.; Gibson, S.; McLaine, A.; Lauterbach, S.; Yaxley, P.; Winston, J.; Diaz-Campos, D.; Pesapane, R.; Flint, M.; Flint, J.; Junge, R.; Faith, S. A.; Bowman, A. S.; Hale, V. L.
10.1101/2022.12.30.522311 — microbiology — Posted on 2022-12-30
93 Sleep increases firing rate modulation during interictal epileptic activities in mesial structures
Whitmarsh, S.; Nguyen-Michel, V.-H.; Lehongre, K.; Mathon, B.; Adam, C.; Lambrecq, V. L.; Frazzini, V.; Navarro, V.
10.1101/2022.12.30.522096 — neuroscience — Posted on 2022-12-30
95 Ventral posterolateral and ventral posteromedial thalamus neurons have distinct synaptic and cellular physiology
Studtmann, C.; Ladislav, M.; Safari, M.; Chen, Y.; Topolski, M. A.; Khondaker, R.; Tomovic, E.; Balik, A.; Swanger, S. A.
10.1101/2022.12.30.521121 — neuroscience — Posted on 2022-12-30
96 Linking acetylated alpha-Tubulin redistribution to alpha-Synuclein pathology in brain of Parkinson's disease patients
Mazzetti, S.; Giampietro, F.; Isilgan, H. B.; Calogero, A. M.; Gagliardi, G.; Rolando, C.; Cantele, F. O.; Ascagni, M.; Bramerio, M. A.; Giaccone, G.; Isaias, I. U.; Pezzoli, G.; Cappelletti, G.
10.1101/2022.12.29.522226 — neuroscience — Posted on 2022-12-30
97 Functionally dissecting claustrum along anterior-posterior axis in anxiety and higher sensitivity to cocaine
Zhao, Z.; Liu, Z.; Chen, L.; Chen, W.; Guo, H.; Wang, J.; Mai, Y.; Wei, X.; Ding, J.; Ge, F.; Fan, Y.; Guan, X.
10.1101/2022.12.30.522289 — neuroscience — Posted on 2022-12-30
100 A multi-omic Nicotiana benthamiana resource for fundamental research and biotechnology
Ranawaka, B.; An, J.; Lorenc, M.; Jung, H.; Sulli, M.; Aprea, G.; Roden, S.; Hayashi, S.; Cooper, T.; LeBlanc, Z.; Llaca, V.; Orzaez, D.; Bombarely, A.; Bally, J.; Winefield, C.; Giuliano, G.; Waterhouse, P. M.
10.1101/2022.12.30.521993 — plant biology — Posted on 2022-12-30
102 Treatment with Tumor-Treating Fields (TTFields) Suppresses Intercellular Tunneling Nanotube Formation In Vitro and Upregulates Immuno-Oncologic Biomarkers In Vivo in Malignant Mesothelioma
Sarkari, A.; Korenfeld, S.; Ladner, K.; Wong, P.; Padmanabhan, S.; Vogel, R. I.; Sherer, L.; Courtemanche, N.; Steer, C.; Wainer-Satsir, K.; Lou, E.
10.1101/2022.12.29.522223 — cancer biology — Posted on 2022-12-30
103 Self-pressurized rapid freezing at arbitrary cryoprotectant concentrations
Rolle, K.; Okotrub, K. A.; Zaytseva, I. V.; Babin, S. A.; Surovtsev, N. V.
10.1101/2022.12.30.522278 — biophysics — Posted on 2022-12-30
108 Inhibition and Disassembly of Tau Aggregates by Engineered Graphene Quantum Dots
Zhu, R.; Makwana, K. M.; Zhang, Y.; Rajewski, B. H.; Del Valle, J. R.; Wang, Y.
10.1101/2022.12.29.522245 — bioengineering — Posted on 2022-12-30
109 An Autoinhibited Conformation of the DnaB-Replicative Helicase phage Lambda P Loader Complex
Jeruzalmi, D.; Brown, D.; Shatarupa, A.; Olinares, P. D.; Chase, J. D.; Isiorho, E.; Chait, B.
10.1101/2022.12.30.522210 — biochemistry — Posted on 2022-12-30
113 MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells
Wang, J.; Fu, Y.; Huang, W.; Biswas, R.; Banerjee, A.; Broussard, J. A.; Zhao, Z.; Wang, D. A.; Bjerke, G. A.; Raghavan, S.; Yan, J.; Green, K. J.; Yi, R.
10.1101/2022.12.29.522250 — genetics — Posted on 2022-12-30
119 Nanofluidic Device for Manipulation and Modification of DNA by Proteins
Dangi, S.; Liu, M.; Azad, Z.; Countryman, P. J.; Roushan, M.; Livshits, G. I.; Kaur, P.; Pan, H.; Shi, Z.; Detwiler, A. C.; Opresko, P. L.; Yu, H.; Wang, H.; Riehn, R.
10.1101/2022.12.29.521498 — biophysics — Posted on 2022-12-30
120 Yttrium-iron garnet film magnetometer for magnetic microparticles in vivo registration studies
Koshev, N.; Kapralov, P.; Evstigneeva, S.; Lutsenko, O.; Shilina, P.; Zharkov, M.; Pyataev, N.; Darwish, A.; Timin, A.; Ostras, M.; Radchenko, I.; Sukhorukov, G.; Vetoshko, P.
10.1101/2022.12.29.522185 — biophysics — Posted on 2022-12-30
125 How collectively integrated are ecological communities?
Zelnik, Y.; Galiana, N.; Barbier, M.; Loreau, M.; Galbraith, E.; Arnoldi, J.-F.
10.1101/2022.12.29.522189 — ecology — Posted on 2022-12-30
128 A probabilistic view of protein stability, conformational specificity, and design
Stern, J. A.; Free, T. J.; Stern, K. L.; Gardiner, S.; Dalley, N. A.; Bundy, B. C.; Price, J. L.; Wingate, D.; Della Corte, D.
10.1101/2022.12.28.521825 — bioinformatics — Posted on 2022-12-30
129 TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene
Kabirova, E.; Ryzhkova, A.; Lukyanchikova, V.; Khabarova, A.; Korablev, A.; Shnaider, T.; Nuriddinov, M.; Belokopytova, P.; Kontsevaya, G.; Serova, I.; Battulin, N.
10.1101/2022.12.29.522177 — genetics — Posted on 2022-12-30
131 An updated end-to-end ecosystem model of the Northern California Current reflecting ecosystem changes due to recent marine heat waves
Gomes, D.; Ruzicka, J. J.; Crozier, L. G.; Huff, D. D.; Phillips, E. M.; Hernvann, P.-Y.; Morgan, C. A.; Brodeur, R. D.; Zamon, J. E.; Daly, E. A.; Bizzarro, J. J.; Fisher, J. L.; Auth, T. D.
10.1101/2022.12.28.522165 — systems biology — Posted on 2022-12-30
132 An efficient method to generate fluorescent amyloid fibrils
Prajapati, K. P.; Ansari, M.; Yadav, D. K.; Anand, B. G.; Mittal, S.; Kar, K.
10.1101/2022.12.28.522083 — biophysics — Posted on 2022-12-30
135 Deep ultraviolet-excited fluorescence histology with fibre optic illumination for microtopography and quantitative tissue mapping
Yong, A. S. K.; Tan, K. H.; Tan, C. W. X.; Ang, J. L. Y.; Kng, J. S. J.; Tan, C. J. J.; Soh, R. H. K.; Tan, R. Y.; Liang, K.
10.1101/2022.12.28.521919 — bioengineering — Posted on 2022-12-30
137 Temperature moderates eDNA-biomass relationships in northern pike
Ogonowski, M.; Karlsson, E.; Vasemagi, A.; Sundin, J.; Bohman, P.; Sundblad, G.
10.1101/2022.12.28.522080 — ecology — Posted on 2022-12-30
138 Repurposing of the antibiotic nitroxoline for the treatment of mpox
Bojkova, D.; Zoeller, N.; Tietgen, M.; Steinhorst, K.; Bechtel, M.; Rothenburger, T.; Kandler, J. D.; Schneider, J.; Corman, V. M.; Ciesek, S.; Rabenau, H. F.; Wass, M. N.; Kippenberger, S.; Göttig, S.; Michaelis, M.; Cinatl, J.
10.1101/2022.12.29.522228 — microbiology — Posted on 2022-12-30
145 Plant age-dependent dynamics of annatto pigment (bixin) biosynthesis in Bixa orellana L.
Machado, K. L. d. G.; Faria, D. V.; Duarte, M. B. S.; Silva, L. A. S.; Oliveira, T. R.; Falcao, T. C. d. A.; Batista, D. S.; Costa, M. G. C.; Santa-Catarina, C.; Silveira, V.; Romanel, E.; Otoni, W. C.; Nogueira, F. T.
10.1101/2022.12.28.522146 — plant biology — Posted on 2022-12-30
146 Genetic and phosphoproteomic basis of LysM-mediated immune signaling in Marchantia polymorpha highlights conserved elements and new aspect of pattern-triggered immunity in land plants
Yotsui, I.; Matsui, H.; Miyauchi, S.; Iwakawa, H.; Melkonian, K.; Schluter, T.; Ibanez, S. G.; Kanazawa, T.; Nomura, Y.; Stolze, S. C.; Jeon, H.-W.; Sugano, S. S.; Shirakawa, M.; Nishihama, R.; Ichihashi, Y.; Shirasu, K.; Ueda, T.; Kohchi, T.; Nakagami, H.
10.1101/2022.12.28.521631 — plant biology — Posted on 2022-12-30
147 The effects of multifactorial stress combination on rice and maize
Sinha, R.; Pelaez-Vico, M.; Shostak, B.; Nguyen, T. T.; Pascual, L. S.; Zandalinas, S. I.; Joshi, T.; Fritschi, F. B.; Mittler, R.
10.1101/2022.12.28.522112 — plant biology — Posted on 2022-12-30
148 A Clinically Useful and Biologically Informative Genomic Classifier for Papillary Thyroid Cancer
Craig, S.; Stretch, C.; Farshidfar, F.; Sheka, D.; Alabi, N.; Siddiqui, A.; Kopciuk, K.; Park, Y. J.; Khalil, M.; Khan, F. M.; Harvey, A.; Bathe, O. F.
10.1101/2022.12.27.522039 — cancer biology — Posted on 2022-12-30
149 Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer
Abdel Hadi, N.; Reyes-Castellanos, G.; Gicquel, T.; Gallardo-Arriaga, S.; Boet, E.; Sarry, J.-E.; Masoud, R.; IOVANNA, J. L.; Carrier, A.
10.1101/2022.12.28.522091 — cancer biology — Posted on 2022-12-30
151 Exact distribution of the vesicle burst size in synaptic transmission
Rijal, K.; Müller, N. I. C.; Friauf, E.; Singh, A.; Prasad, A.; Das, D.
10.1101/2022.12.28.522121 — biophysics — Posted on 2022-12-30
153 Towards reliable reconstruction of the mouse brain thalamocortical connectivity using diffusion MRI
Arefin, T. M.; Lee, C. H.; Liang, Z.; Rallapalli, H.; Wadghiri, Y. Z.; Turnbull, D. H.; Zhang, J.
10.1101/2022.12.28.522151 — bioengineering — Posted on 2022-12-30
155 A new framework for metabolic connectivity mapping using bolus FDG PET and kinetic modelling
Volpi, T.; Vallini, G.; Silvestri, E.; De Francisci, M.; Durbin, T.; Corbetta, M.; Lee, J. J.; Vlassenko, A. G.; Goyal, M. S.; Bertoldo, A.
10.1101/2022.12.27.522050 — bioengineering — Posted on 2022-12-30
156 Forces driving transposable element load variation during Arabidopsis range expansion
Jiang, J.; Xu, Y.-C.; Zhang, Z.-Q.; Chen, J.-F.; Niu, X.-M.; Hou, X.-H.; Li, X.-T.; Wang, L.; Zhang, Y.; Ge, S.; Guo, Y.
10.1101/2022.12.28.522087 — evolutionary biology — Posted on 2022-12-30
158 Defining ancestry, heritability and plasticity of cellular phenotypes in somatic evolution
Schiffman, J. S.; D'Avino, A. R.; Prieto, T.; Potenski, C.; Fan, Y.; Hara, T.; Suva, M. L.; Landau, D. A.
10.1101/2022.12.28.522128 — evolutionary biology — Posted on 2022-12-30
160 Mapping Tree Cover Expansion in Montana, U.S.A. Rangelands using High-Resolution Historical Aerial Imagery
Morford, S. L.; Allred, B. W.; Jensen, E. R.; Maestas, J. D.; Mueller, K. R.; Pacholski, C. L.; Smith, J. T.; Tack, J. D.; Tackett, K. N.; Naugle, D. E.
10.1101/2022.12.28.522142 — ecology — Posted on 2022-12-30
161 Phylogenetic endemism of the world's seed plants
Cai, L.; Kreft, H.; Taylor, A.; Schrader, J.; Dawson, W.; Essl, F.; van Kleunen, M.; Pergl, J.; Pysek, P.; Winter, M.; Weigelt, P.
10.1101/2022.12.28.522105 — ecology — Posted on 2022-12-30
162 A versatile semiautomated image analysis workflow for time-lapsed camera trap image classification.
Celis, G.; Ungar, P. S.; Sokolov, A.; Sokolova, N.; Böhner, H.; Liu, D.; Ziker, J.; Gilg, O.; Fufachev, I.; Pokrovskay, O.; Ims, R. A.; Ivanov, V.; Ehrich, D.
10.1101/2022.12.28.522027 — ecology — Posted on 2022-12-30
163 Cytokine-expression patterns reveal coordinated immunological programs associated with persistent MRSA bacteremia
Chin, J. L.; Tan, Z. C.; Chan, L. C.; Ruffin, F.; Parmar, R.; Ahn, R.; Taylor, S.; Bayer, A. S.; Hoffman, A.; Fowler, V. G.; Reed, E. F.; Yeaman, M. R.; Meyer, A. S.; MRSA Systems Immunobiology Group,
10.1101/2022.12.28.521386 — immunology — Posted on 2022-12-30
166 Cultivation of plant-growth promoters in vinasse: contributions for a circular and green economy
Torres, M. A.; Valdez, A. L.; Angelicola, M. V.; Raimondo, E. E.; Pajot, H. F.; Nieto Penalver, C. G.
10.1101/2022.12.28.522132 — bioengineering — Posted on 2022-12-30
168 Diaci v3.0: Chromosome-level assembly, de novo transcriptome and manual annotation of Diaphorina citri, insect vector of Huanglongbing
Shippy, T. D.; Hosmani, P. S.; Flores-Gonzalez, M.; Mann, M.; Miller, S.; Weirauch, M. T.; Vosburg, C.; Massimino, C.; Tank, W.; de Oliveira, L.; Chen, C.; Hoyt, S.; Adams, R.; Adkins, S.; Bailey, S. T.; Chen, X.; Davis, N.; DeLaFlor, Y.; Espino, M.; Gervais, K.; Grace, R.; Harper, D.; Hasan, D. L.; Hoang, M.; Holcomb, R.; Jernigan, M. R.; Kemp, M.; Kennedy, B.; Kercher, K.; Klaessan, S.; Kruse, A.; Licata, S.; Lu, A.; Masse, R.; Mathew, A.; Michels, S.; Michels, E.; Neiman, A.; Norman, S.; Norus, J.; Ortiz, Y.; Panitz, N.; Paris, T.; Perentesis, K. M. R.; Perry, M.; Reynolds, M.; Sena, M. M.;
10.1101/869685 — genomics — Posted on 2022-12-30
170 D1RCaMKII in claustrum mediates adolescent cocaine exposure-induced anxiety and electro-acupuncture therapy
Chen, L.; Fan, Y.; Liu, Z.; Zhao, Z.; Du, D.; Pan, W.; Wei, X.; Nie, J.; Ge, F.; Ding, J.; Kim, H. Y.; Guan, X.
10.1101/2022.10.18.512685 — neuroscience — Posted on 2022-12-30
175 Selective transduction and photoinhibition of pre-Botzinger neurons that project to the facial nucleus in rats affect the nasofacial activity
Melo, M. R.; Wykes, A. D.; Connelly, A. A.; Bassi, J. K.; Cheung, S. D.; McDougall, S. J.; Menuet, C.; Bathgate, R. A.; Allen, A. M.
10.1101/2022.12.28.522095 — neuroscience — Posted on 2022-12-30
176 Metastatic infiltration of nervous tissue and periosteal nerve sprouting in multiple myeloma induced bone pain
Diaz-delCastillo, M.; Palasca, O.; Nemler, T. T.; Thygesen, D. M.; Chavez-Saldana, N. A.; Vazquez-Mora, J. A.; Ponce Gomez, L. Y.; Juhl Jensen, L.; Evans, H.; Andrews, R. E.; Mandal, A.; Neves, D.; Mehlen, P.; Caruso, J. P.; Dougherty, P. M.; Price, T. J.; Chantry, A.; Lawson, M. A.; Andersen, T. L.; Jimenez-Andrade, J. M.; Heegaard, A.-M.
10.1101/2022.12.29.522199 — neuroscience — Posted on 2022-12-30
178 Insights into mammalian TE diversity via the curation of 248 mammalian genome assemblies
Osmanski, A. B.; Paulat, N. S.; Korstian, J.; Grimshaw, J. R.; Halsey, M.; Sullivan, K. A. M.; Moreno-Santillan, D. D.; Crookshanks, C.; Roberts, J.; Garcia, C.; Johnson, M. G.; Densmore, L. D.; Stevens, R. D.; Zoonomia Consortium, ; Rosen, J.; Storer, J. M.; Hubley, R.; Smit, A. F. A.; Davalos, L. M.; Karlsson, E. K.; Lindblad-Toh, K.; Ray, D. A.
10.1101/2022.12.28.522108 — genomics — Posted on 2022-12-30
179 Pioneer transcription factors coordinate active and repressive gene expression states to regulate cell fate
Matsui, S.; Granitto, M.; Buckley, M.; Shiley, J.; Zacharias, W.; Mayhew, C.; Lim, H.-W.; Iwafuchi, M.
10.1101/2022.12.29.522251 — cell biology — Posted on 2022-12-30
183 Integrative study of mitochondrial dysfunction in skeletal muscle during pancreatic cancer cachexia
Gicquel, T.; Marchiano, F.; Reyes-Castellanos, G.; Audebert, S.; Camoin, L.; Habermann, B. H.; Giannesini, B.; Carrier, A.
10.1101/2022.12.28.522098 — cancer biology — Posted on 2022-12-29
184 Latent representation of single-cell transcriptomes enables algebraic operations on cellular phenotypes
Sengupta, D.; Nelson, C. C.; Bhattacharya, N.; Rockstroh, A.; Roquilly, A.; Hollier, B.; Ahuja, G.; Kumar, H.; Poschmann, J.; Lehman, M.; Thomas, S. K.; Deshpande, S. S.; Chawla, S.; Solomon, P.; Fourgeux, C.
10.1101/2022.12.28.522060 — bioinformatics — Posted on 2022-12-30
187 High-quality nuclear genome and mitogenome of Bipolaris sorokiniana strain LK93, a devastating pathogen causing wheat root rot
Zhang, W.; Yang, Q.; Yang, L.; Li, H.; Zhou, W.; Meng, J.; Hu, Y.; Wang, L.; Kang, R.; Li, H.; Ding, S.; Li, G.
10.1101/2022.12.28.522073 — plant biology — Posted on 2022-12-29
188 Chromatin organization drives the exploration strategy of nuclear factors
Mazzocca, M.; Loffreda, A.; Colombo, E.; Fillot, T.; Gnani, D.; Falletta, P.; Monteleone, E.; Capozi, S.; Bertrand, E.; Legube, G.; Lavagnino, Z.; Tacchetti, C.; Mazza, D.
10.1101/2022.12.29.522193 — biophysics — Posted on 2022-12-29
190 One-shot design elevates functional expression levels of a voltage-gated potassium channel
Weinstein, J. J.; Saikia, C.; Karbat, I.; Goldenzweig, A.; Reuveny, E.; Fleishman, S. J.
10.1101/2022.12.28.522065 — biochemistry — Posted on 2022-12-29
192 ERCC1 mice, unlike other premature aging models, display accelerated epigenetic age
Perez, K.; Parras, A.; Reichsteiner, C.; Haghani, A.; Brooke, R.; Mrabti, C.; Schoenfeldt, L.; Horvath, S.; Ocampo, A.
10.1101/2022.12.28.522011 — molecular biology — Posted on 2022-12-29
194 A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma
Schleussner, N.; Cauchy, P.; Franke, V.; Giefing, M.; Fornes, O.; Vankadari, N.; Assi, S.; Costanza, M.; Weniger, M. A.; Akalin, A.; Anagnostopoulos, I.; Bukur, T.; Casarotto, M. G.; Damm, F.; Daumke, O.; Edginton-White, B.; Gebhardt, J. C. M.; Grau, M.; Grunwald, S.; Hansmann, M.-L.; Hartmann, S.; Huber, L.; Kärgel, E.; Lusatis, S.; Noerenberg, D.; Obier, N.; Pannicke, U.; Pfaus, A.; Reisser, A.; Rosenwald, A.; Schwarz, K.; Sundararaj, S.; Weilemann, A.; Winkler, W.; Xu, W.; Lenz, G.; Rajewsky, K.; Wasserman, W. W.; Cockerill, P. N.; Scheidereit, C.; Siebert, R.; Küppers, R.; Grosschedl, R.
10.1101/2022.12.29.522203 — cancer biology — Posted on 2022-12-29
197 Interfacial dynamics and growth modes of β2-microglobulin dimers
Oliveira, N. F. B.; Rodrigues, F. E. P.; Vitorino, J. N. M.; Faisca, P. F. N.; Machuqueiro, M.
10.1101/2022.12.28.522115 — biophysics — Posted on 2022-12-29
199 Human TRMT2A methylates different components of the translation machinery and contributes to translation fidelity
Witzenberger, M.; Burczyk, S.; Welp, L. M.; Wagner, M.; Monecke, T.; Janowski, R.; Carell, T.; Urlaub, H.; Hauck, S. M.; Voigt, A.; Niessing, D.
10.1101/2022.12.28.522094 — biochemistry — Posted on 2022-12-29
201 BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA
Bell, J. C.; Dombrowski, C. C.; Plank, J. L.; Jensen, R. B.; Kowalczykowski, S. C.
10.1101/2022.12.28.522061 — biochemistry — Posted on 2022-12-29
202 Dynamic protein deacetylation is a limited carbon source for acetyl-CoA-dependent metabolism
Soaita, I.; Megill, E.; Kantner, D.; Chatoff, A.; Arany, Z.; Snyder, N. W.; Wellen, K. E.; Trefely, S. W.
10.1101/2022.12.28.522149 — biochemistry — Posted on 2022-12-29
203 Porcine cytomegalovirus detection by nanopore-based metagenomic sequencing in a Hungarian pig farm
Toth, A. G.; Fiam, R.; Becsei, A.; Spisak, S.; Csabai, I.; Makrai, L.; Reibling, T.; Solymosi, N.
10.1101/2022.12.28.522123 — genomics — Posted on 2022-12-29
204 Systematic characterization of Drosophila RhoGEF/GAP localizations uncovers regulators of mechanosensing and junction formation during epithelial cell division.
di Pietro, F.; Osswald, M.; De las Heras, J. M.; Cristo, I.; Lopez-Gay, J.; Wang, Z.; Pelletier, S.; Gaugue, I.; Leroy, A.; Morais-De-Sa, E.; Bellaiche, Y.
10.1101/2022.12.29.522184 — developmental biology — Posted on 2022-12-29
207 Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: a new approach to prevent and treat bacterial infections
Johnson, K.; Delaney, J.; Guillard, T.; Reffuveille, F.; Varin-Simon, J.; Li, K.; Wollacott, A.; Frapy, E.; Mong, S.; Tissire, H.; Viswanathan, K.; Touti, F.; Babcock, G.; Shriver, Z.; Pentelute, B.; Plante, O.; Skurnik, D.
10.1101/2022.12.28.522163 — microbiology — Posted on 2022-12-29
208 Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens
Morrison, H. M.; Craft, J.; Rivera-Lugo, R.; Johnson, J. R.; Golovkine, G. R.; Dodd, C. E.; Van Dis, E.; Beatty, W. L.; Margolis, S. R.; Repasy, T.; Shaker, I.; Lee, A. Y.; Vance, R. E.; Stanley, S. A.; Krogan, N. J.; Portnoy, D. A.; Penn, B. H.; Cox, J. S.
10.1101/2022.12.29.522180 — immunology — Posted on 2022-12-29
209 Release of large synaptic DCV proteins is triggered by Ca2+-independent Rugose-localized complexin phosphorylation
Bulgari, D.; Cavolo, S. L.; Schmidt, B. F.; Buchan, K.; Bruchez, M. P.; Deitcher, D. L.; Levitan, E.
10.1101/2022.12.24.521856 — neuroscience — Posted on 2022-12-29
216 Exercise rejuvenates the skeletal muscle methylome and transcriptome in humans
Voisin, S.; Seale, K.; Jacques, M.; Landen, S.; Harvey, N. R.; Haupt, L. M.; Griffiths, L. R.; Ashton, K. J.; Coffey, V. G.; Thompson, J.-L. M.; Doering, T. M.; Lindholm, M. E.; Walsh, C.; Davison, G.; Irwin, R.; McBride, C.; Hansson, O.; Asplund, O.; Heikkinen, A. E.; Piirila, P.; Pietilainen, K.; Ollikainen, M.; Blocquiaux, S.; Thomis, M.; Sharples, A. P.; Eynon, N.
10.1101/2022.12.27.522062 — molecular biology — Posted on 2022-12-29
217 Fecal Microbiota Restoration Modulates the Microbiome in Inflammation-Driven Colorectal Cancer
Gates, T. J.; Yuan, C. J.; Shetty, M.; Kaiser, T.; Nelson, A. C.; Chauhan, A.; Starr, T. K.; Staley, C.; Subramanian, S.
10.1101/2022.12.28.522045 — microbiology — Posted on 2022-12-29
218 Core respiratory microbiome of the blue whale, Balaenoptera musculus
Dominguez-Sanchez, C.; Alvarez-Martinez, R.; Gendron, D.; Acevedo-Whitehouse, K.
10.1101/2022.12.29.522252 — microbiology — Posted on 2022-12-29
220 Pre-clinical in vitro and in vivo characterization of a maternal vaccination before conception to protect against severe neonatal infections caused by Escherichia coli K1
Sereme, Y.; Schrimpf, C.; Lefebvre-Wloszczowski, E.; Agapoff, M.; Faury, H.; Chang-Marchand, Y.; Agiron-Ardila, E.; Panafieu, E.; Blec, F.; Coureuil, M.; Frapy, E.; Bonacorsi, S.; Skurnik, D.
10.1101/2022.12.29.522168 — microbiology — Posted on 2022-12-29
223 Sparse and stereotyped encoding implicates a core glomerulus for ant alarm behavior
Hart, T.; Frank, D.; Lopes, L. E.; Olivos-Cisneros, L.; Lacy, K. D.; Trible, W.; Ritger, A.; Valdes-Rodriguez, S.; Kronauer, D. J. C.
10.1101/2022.12.29.522224 — neuroscience — Posted on 2022-12-29
225 SATB2 organizes the 3D genome architecture of cognition in cortical neurons
Wahl, N.; Espeso-Gil, S.; Chietera, P.; Laighneach, A.; Morris, D. W.; Rajarajan, P.; Akbarian, S.; Dechant, G.; Apostolova, G.
10.1101/2022.12.27.522010 — neuroscience — Posted on 2022-12-29
226 Erythromycin, Retapamulin, Pyridoxine, Folic acid, and Ivermectin dose-dependently inhibit cytopathic effect, Papain-like Protease, and MPRO of SARS-CoV-2
Bello, S. O.; Imam, M. U.; Bello, M. B.; Yunusa, A.; Adamu, A. A.; Shuaibu, A.; Igumbor, E. U.; Habib, Z. G.; Popoola, M. A.; Ochu, C. L.; Bello, A. Y.; Deeni, Y. Y.; Okoye, I.
10.1101/2022.12.28.522082 — pharmacology and toxicology — Posted on 2022-12-29
230 Astroglial mediation of fast-acting antidepressant effect in zebrafish
Duque, M.; Chen, A. B.; Narayan, S.; Olson, D. E.; Fishman, M. C.; Engert, F.; Ahrens, M. B.
10.1101/2022.12.29.522099 — neuroscience — Posted on 2022-12-29
237 Antibiotic-induced dysbiosis does not potentiate the effect of lipopolysaccharide insult in male Wistar rats
Tejkalova, H.; Jakob, L.; Kvasnova, S.; Klaschka, J.; Sechovcova, H.; Mrazek, J.; Palenicek, T.; Fliegerova, K. O.
10.1101/2022.12.29.522253 — neuroscience — Posted on 2022-12-29
238 Whole-Brain Three-Dimensional Imaging of RNAs at Single-Cell Resolution
Kanatani, S.; Kreutzmann, J. C.; Li, Y.; West, Z.; Vougesi Nikou, D.; Lercke Skytte, J.; Lydolph Larsen, L.; Tanaka, D. H.; Kaczynska, D.; Fukumoto, K.; Uesaka, N.; Tanabe, T.; Miyakawa, A.; Roostalu, U.; Hecksher-Sorensen, J.; Uhlen, P.
10.1101/2022.12.28.521740 — neuroscience — Posted on 2022-12-29
239 Individual light history matters to cope with the Antarctic summer
Castillo-Stratta, J.; Tonon, A. C.; Hidalgo, M. P.; Silva, A.; Tassino, B.
10.1101/2022.12.29.522237 — neuroscience — Posted on 2022-12-29
241 Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity
Ferreira, A. C.; Hemmer, B. M.; Philippi, S. M.; Liu, H.; Zhu, J. D.; Kareva, T.; Ahfeldt, T.; Varghese, M.; Hof, P. R.; Castellano, J. M.
10.1101/2022.12.28.522138 — neuroscience — Posted on 2022-12-29
242 Distinct spatial patterns of neural and physiology-related activity in the human periaqueductal grey during anticipatory social stress.
Theriault, J. E.; Fischbach, A. K.; Kragel, P. A.; Wager, T. D.; Wald, L. L.; Bianciardi, M.; Quigley, K. S.; Barrett, L. F.; Satpute, A. B.
10.1101/2022.12.29.522243 — neuroscience — Posted on 2022-12-29
243 Longitudinal Characterization of Cerebral Hemodynamicsin the TgF344-AD Rat Model of Alzheimer's Disease
Fang, X.; Tang, C.; Zhang, H.; Border, J. J.; Liu, Y.; Shin, S. M.; Yu, H.; Roman, R. J.; Fan, F.
10.1101/2022.12.29.522215 — neuroscience — Posted on 2022-12-29
244 An Open-Source Rodent Chronic EEG Array System with High Density MXene-Based Skull Surface Electrodes
Ding, L.; Patel, A.; Shankar, S.; Driscoll, N.; Zhou, C.; rex, T. S.; Vitale, F.; Gallagher, M. J.
10.1101/2022.12.28.522126 — neuroscience — Posted on 2022-12-29
246 Why the brown ghost chirps at night
Oboti, L.; Pedraja, F.; Ritter, M.; Lohse, M.; Klette, L.; Krahe, R.
10.1101/2022.12.29.522225 — animal behavior and cognition — Posted on 2022-12-29
248 Molecular and spatial design of early skin development
Jacob, T.; Annusver, K.; Czarnewski, P.; Dalessandri, T.; Kastriti, M. E.; Levron, C. L.; Mikkola, M.; Rendl, M.; Lichtenberger, B.; Donati, G.; Bjorklund, A.; Kasper, M.
10.1101/2022.12.28.522081 — developmental biology — Posted on 2022-12-29
250 MYC directly transactivates CR2/CD21, the receptor of the Epstein-Barr virus, and enhances the viral infection of Burkitt lymphoma cells
Molina, E.; Garcia-Gutierrez, L.; Junco, V.; Perez-Olivares, M.; G de Yebenes, V.; Blanco, R.; Quevedo, L.; Acosta, J. C.; Marin, A. V.; Ulgiati, D.; Merino, R.; Varela, I.; Regueiro, J. R.; Moreno de Alboran, I.; Ramiro, A.; Leon, J.
10.1101/2022.12.28.522143 — cancer biology — Posted on 2022-12-29
251 Location and concentration of aromatic-rich segments dictates the percolating inter-molecular network and viscoelastic properties of ageingcondensates
Blazquez, S.; Sanchez-Burgos, I.; Ramirez, J.; Higginbotham, T.; Conde, M. M.; Collepardo-Guevara, R.; Tejedor, A. R.; Espinosa, J. R.
10.1101/2022.12.14.520383 — biophysics — Posted on 2022-12-29
252 Pushing the envelope: force balance in fission yeast closed mitosis
Begley, M. A.; Pagan Medina, C.; Zareiesfandabadi, P.; Rapp, M. B.; Elting, M. W.
10.1101/2022.12.28.522145 — biophysics — Posted on 2022-12-29
253 LHX2 in germ cells control tubular organization in the developing mouse testis
Singh, N.; Singh, D.; Bhide, A.; Sharma, R.; Bhowmick, S.; Patel, V.; Modi, D.
10.1101/2022.12.29.522214 — developmental biology — Posted on 2022-12-29
254 The shh limb enhancer is activated in patterned limb regeneration but not in hypomorphic limb regeneration in Xenopus laevis
Tada, R.; Higashidate, T.; Amano, T.; Ishikawa, S.; Yokoyama, C.; Nara, S.; Ishida, K.; Kawaguchi, A.; Ochi, H.; Ogino, H.; Yakushiji-Kaminatsui, N.; Sakamoto, J.; Kamei, Y.; Tamura, K.; Yokoyama, H.
10.1101/2022.12.27.522067 — developmental biology — Posted on 2022-12-29
255 The C. elegans Anchor Cell Transcriptome: Ribosome Biogenesis Drives Cell Invasion through Basement Membrane
Costa, D. S.; Kenny-Ganzert, I. W.; Chi, Q.; Park, K.; Kelley, L. C.; Garde, A.; Matus, D. Q.; Park, J.; Yogev, S.; Goldstein, B.; Gibney, T. V.; Pani, A. M.; Sherwood, D. R.
10.1101/2022.12.28.522136 — cell biology — Posted on 2022-12-29
258 Immunogenicity of COVID-eVax Is Moderately Impacted by Temperature and Molecular Isoforms
D'Alessio, F.; Lione, L.; Salvatori, E.; Bucci, F.; Muzi, A.; Roscilli, G.; Conforti, A.; Compagnone, M.; Pinto, E.; Battistuzzi, G.; Aurisicchio, L.; Palombo, F.
10.1101/2022.12.29.522202 — immunology — Posted on 2022-12-29
260 GDF15 Is Required for Cold-Induced Thermogenesis and Contributes to Improve Systemic Metabolic Health Following Loss of OPA1 in Brown Adipocytes
Jena, J.; Pena, L. M. G.; Weatherford, E. T.; Marti, A.; Bjorkman, S. H.; Kato, K.; Koneru, J.; Chen, J. H.; Seeley, R.; Abel, E. D.; Pereira, R. O.
10.1101/2022.12.23.521796 — physiology — Posted on 2022-12-29
262 A robust deep learning platform to predict CD8+ T-cell epitopes
Lee, C. H.-J.; Huh, J.; Buckley, P. R.; Jang, M. J.; Pereira Pinho, M.; Fernandes, R.; Antanaviciute, A.; Simmons, A.; Koohy, H.
10.1101/2022.12.29.522182 — bioinformatics — Posted on 2022-12-29
270 Origin of wiring specificity in an olfactory map: dendrite targeting of projection neurons
Wong, K. K. L.; Li, T.; Fu, T.-M.; Liu, G.; Lyu, C.; Kohani, S.; Xie, Q.; Luginbuhl, D. J.; Upadhyayula, G.; Betzig, E.; Luo, L.
10.1101/2022.12.28.522173 — neuroscience — Posted on 2022-12-29
272 An electrophysiological and kinematic model of Paramecium, the "swimming neuron"
Elices, I.; Kulkarni, A.; Escoubet, N.; Pontani, L.-L.; Prevost, A. M.; Brette, R.
10.1101/2022.02.15.480485 — neuroscience — Posted on 2022-12-29
278 Irradiated Mammary Spheroids Elucidate Mechanisms of Macrophage-Mediated Breast Cancer Recurrence
Hacker, B. C.; Herman, D. C.; Lin, E. J.; Questell, A. M.; Martello, S. E.; Hedges, R. J.; Walker, A. J.; Rafat, M.
10.1101/2022.07.24.501296 — cancer biology — Posted on 2022-12-29
280 Intranasal inhibitor broadly blocks SARS-CoV-2 including recent highly immunoevasive Omicron subvariants
Mäkelä, A. R.; Ugurlu, H.; Hannula, L.; Salminen, P.; Kant, R.; Fagerlund, R.; Mäki, S.; Haveri, A.; Strandin, T.; Kareinen, L.; Hepojoki, J.; Levanov, L.; Pasternack, A.; Naves, R. A.; Ritvos, O.; Österlund, P.; Sironen, T.; Vapalahti, O.; Kipar, A.; Huiskonen, J. T.; Rissanen, I.; Saksela, K.
10.1101/2021.12.28.474326 — microbiology — Posted on 2022-12-29
284 Single Cell Cortical Bone Transcriptomics Defines Novel Osteolineage Gene Sets Altered in Chronic Kidney Disease
Agoro, R.; Nookaew, I.; Noonan, M.; Marambio, Y. G.; Liu, S.; Chang, W.; Gao, H.; Hibbard, L. M.; Metzger, C. E.; Horan, D.; Thompson, W. R.; Xuei, X.; Liu, Y.; Zhang, C.; Robling, A. G.; Bonewald, L. F.; Wan, J.; White, K. E.
10.1101/2022.07.30.502024 — cell biology — Posted on 2022-12-28
285 DNp63 Regulates Homeostasis, Stemness, and Suppression of Inflammation in the Adult Epidermis
Alexandrova, E. M.; Eyermann, C. E.; Chen, X.; Somuncu, O. S.; Li, J.; Joukov, A. N.; Chen, J.
10.1101/2022.08.17.504172 — cell biology — Posted on 2022-12-28
287 Id2 GABAergic interneurons: a neglected fourth major group of cortical inhibitory cells
Machold, R. P.; Dellal, S.; Valero, M.; Zurita, H.; Kruglikov, I.; Meng, J. H.; Hanson, J. L.; Hashikawa, Y.; Schuman, B.; Buzsaki, G.; Rudy, B.
10.1101/2022.12.01.518752 — neuroscience — Posted on 2022-12-28
289 Characterisation of emergent toxigenic M1UK Streptococcus pyogenes and associated sublineages
Li, H. K.; Zhi, X.; Vieira, A.; Whitwell, H. J.; Schricker, A.; Jauneikaite, E.; Li, H.; Yosef, A.; Andrew, I.; Game, L.; Turner, C. E.; Lamagni, T.; Coelho, J.; Sriskandan, S.
10.1101/2022.12.27.522030 — microbiology — Posted on 2022-12-28
290 Cataloguing and profiling of the gut virome in Chinese populations uncover extensive viral signatures across common diseases
Li, S.; Yan, Q.; Wang, G.; Zhang, Y.; Guo, R.; Zhang, P.; Lv, Q.; Chen, F.; Zhiming, L.; Meng, J.; Li, J.; Chen, C.; ULLAH, H.; Cheng, L.; Fan, S.; Li, R.; You, W.; Zhang, Y.; Ma, J.; Sun, W.; Ma, X.
10.1101/2022.12.27.522048 — microbiology — Posted on 2022-12-28
291 Development and evaluation of a formulation of probiont Phaeobacter inhibens S4 for themanagement of vibriosis in bivalve hatcheries
Takyi, E.; LaPorte, J.; Sohn, S.; Stevick, R. J.; Witkop, E. M.; Gregg, L.; Chesler-Poole, A.; Small, J.; White, M. M.; Giray, C.; Rowley, D. C.; Nelson, D. R.; Gomez-Chiarri, M.
10.1101/2022.12.27.522043 — microbiology — Posted on 2022-12-28
294 Transient Water Wires Mediate Selective Proton Conduction in Designed Channel Proteins
Kratochvil, H. T.; Watkins, L. C.; Mravic, M.; Somberg, N. H.; Thomaston, J. L.; Nicoludis, J. M.; Liu, L.; Hong, M.; Voth, G. A.; DeGrado, W.
10.1101/2022.03.28.485852 — biophysics — Posted on 2022-12-28
295 Defining protein variant functions using high-complexity mutagenesis libraries and enhanced mutant detection software ASMv1.0
Yang, X.; Hong, A. L.; Sharpe, T.; Giacomelli, A. O.; Lintner, R. E.; Alan, D.; Green, T.; Hayes, T. K.; Piccioni, F.; Fritchman, B.; Kawabe, H.; Sawyer, E.; Sprenkle, L.; Lee, B. P.; Persky, N. S.; Brown, A.; Greulich, H.; Aguirre, A. J.; Meyerson, M.; Hahn, W. C.; Johannessen, C. M.; Root, D. E.
10.1101/2021.06.16.448102 — systems biology — Posted on 2022-12-28
296 Breast Cancer Reaction-Diffusion from Spectral-Spatial Analysis in Immunohistochemistry
Pasetto, S.; Zahid, M. U.; Diaz, R.; Montejo, M.; Rosa, M.; Gatenby, R.; Enderling, H.
10.1101/2022.07.10.499460 — cancer biology — Posted on 2022-12-28
297 Probabilities of HIV-1 bNAb development in healthy and chronically infected individuals
Kreer, C.; Lupo, C.; Ercanoglu, M. S.; Gieselmann, L.; Spisak, N.; Grossbach, J.; Schlotz, M.; Schommers, P.; Gruell, H.; Dold, L.; Beyer, A.; Nourmohammad, A.; Mora, T.; Walczak, A.; Klein, F.
10.1101/2022.07.11.499584 — immunology — Posted on 2022-12-28
298 Efficient 3D light-sheet imaging of very large-scale optically cleared human brain and prostate tissue samples.
Schueth, A. A.; Hildebrand, S. S.; Samarska, I.; Sengupta, S.; Kiessling, A.; Herrler, A.; zur Hausen, A.; Capalbo, M.; Roebroeck, A.
10.1101/2022.07.14.500098 — neuroscience — Posted on 2022-12-28
300 Foreign body reaction is triggered in vivo by cellular mechanosensing of implants stiffer than host tissue
Carnicer-Lombarte, A.; Barone, D. G.; Dimov, I. B.; Hamilton, R. S.; Prater, M.; Zhao, X. X.; Rutz, A. L.; Malliaras, G. G.; Lacour, S. P.; Bryant, C. E.; Fawcett, J. W.; Franze, K.
10.1101/829648 — bioengineering — Posted on 2022-12-28
303 CRISPR/Cas9-based repeat depletion for the high-throughput genotyping of complex plant genomes
Rossato, M.; Marcolungo, L.; De Antoni, L.; Lopatriello, G.; Bellucci, E.; Cortinovis, G.; Frascarelli, G.; Nanni, L.; Bitocchi, E.; Di Vittori, V.; Vincenzi, L.; Lucchini, F.; Bett, K.; Ramsay, L.; Konkin, D. J.; Delledonne, M.; Papa, R.
10.1101/2022.11.22.517518 — genomics — Posted on 2022-12-27
309 GDF15 mediates renal cell plasticity in response to potassium depletion
Lasaad, S.; Walter, C.; Rafael, C.; Morla, L.; Doucet, A.; Picard, N.; Blanchard, A.; Fromes, Y.; Matot, B.; Crambert, G.; Cheval, L.
10.1101/2022.12.27.521983 — physiology — Posted on 2022-12-27
317 Developmental stage-dependent effects of perceived predation risk on physiology and fledging success of tree swallows (Tachycineta bicolor)
McNew, S.; Taff, C. C.; Zimmer, C.; Uehling, J.; Ryan, T. A.; von Oordt, D. C.; Houtz, J. L.; Injaian, A. S.; Vitousek, M. N.
10.1101/2022.12.27.522041 — ecology — Posted on 2022-12-27
321 Viral and host small RNA transcriptome analysis of SARS-CoV-1 and SARS-CoV-2-infected human cells reveals novel viral short RNAs.
Driedonks, T.; Nyberg, L.; Conte, A.; Ma, Z.; Pekosz, A.; Duban, E.; Sültmann, H.; Turchinovich, A.; Witwer, K.
10.1101/2022.12.27.522023 — molecular biology — Posted on 2022-12-27
322 IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data
Peres, A.; Lees, W. D.; Rodriguez, O. L.; Lee, N. Y.; Polak, P.; Hope, R.; Kedmi, M.; Collins, A. M.; Ohlin, M.; Kleinstein, S. H.; Watson, C.; Yaari, G.
10.1101/2022.12.26.521922 — immunology — Posted on 2022-12-27
329 Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome.
Tobacyk, J.; Parks, B. J.; Salazar, P.; Coward, L.; Berquist, M. D.; Gorman, G. S.; Brents, L. K.
10.1101/2022.12.27.521115 — pharmacology and toxicology — Posted on 2022-12-27
331 ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
Farmaki, E.; Nath, A.; Emond, R.; Karimi, K. L.; Grolmusz, V. K.; Cosgrove, P. A.; Bild, A. H.
10.1101/2022.12.27.522019 — cancer biology — Posted on 2022-12-27
332 Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
Iyer, S. R.; Nusser, K.; Jones, K.; Shinde, P.; Beach, C. Z.; Keddy, C.; Aguero, E.; Force, J.; Shinde, U.; Davare, M. A.
10.1101/2022.12.27.521482 — cancer biology — Posted on 2022-12-27
336 CoBeL-RL: A neuroscience-oriented simulation framework for complex behavior and learning
Diekmann, N.; Vijayabaskaran, S.; Zeng, X.; Kappel, D.; Menezes, M. C.; Cheng, S.
10.1101/2022.12.27.521997 — bioinformatics — Posted on 2022-12-27
337 Simultaneous visualization of cells and marker genes from scRNA-seq studies
Sengupta, D.; Gupta, K.; Ahuja, G.; Chakraborty, T.; Chakraborti, S.; Mittal, A.; Sinha, D.
10.1101/2022.12.27.521966 — bioinformatics — Posted on 2022-12-27
338 In situ genetically targeted chemical assembly of polymers on living neuronal membranes
Zhang, A.; Loh, K. Y.; Kadur, C. S.; Michalek, L.; Dou, J.; Ramakrishnan, C.; Bao, Z.; Deisseroth, K.
10.1101/2022.12.27.521974 — bioengineering — Posted on 2022-12-27
340 A 3D Clinical Face Phenotype Space of Genetic Syndromes using a Triplet-Based Singular Geometric Autoencoder
Mahdi, S. S.; Matthews, H.; Vanneste, M.; Nauwelaers, N.; Gong, S.; Bouritsas, G.; Baynam, G. S.; Hammond, P.; Spritz, R.; Klein, O. D.; Hallgrimsson, B. D.; Peeters, H.; Claes, P.
10.1101/2022.12.27.521999 — bioengineering — Posted on 2022-12-27
342 PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
Mayayo-Peralta, I.; Gregoricchio, S.; Schuurman, K.; Yavuz, S.; Zaalberg, A.; Kojic, A.; Abbott, N.; Geverts, B.; Beerthuijzen, S.; Siefert, J.; Severson, T.; van Baalen, M.; Hoekman, L.; Lieftink, C.; Altelaar, M.; Beijersbergen, R. L.; Houtsmuller, A. B.; Prekovic, S.; Zwart, W.
10.1101/2022.12.27.521987 — genomics — Posted on 2022-12-27
347 Demystifying image-based machine learning: A practical guide to automated analysis of field imagery using modern machine learning tools
Belcher, B. T.; Bower, E. H.; Burford, B.; Celis, M. R.; Fahimipour, A. K.; Guevara, I. L.; Katija, K.; Khokhar, Z.; Manjunath, A.; Nelson, S.; Olivetti, S.; Orenstein, E.; Saleh, M. H.; Vaca, B.; Valladares, S.; Hein, S. A.; Hein, A. M.
10.1101/2022.12.24.521836 — ecology — Posted on 2022-12-27
348 Mapping variation in the morphological landscape of human cells with optical pooled CRISPRi screening
Labitigan, R. L. D.; Sanborn, A. L.; Hao, C. V.; Chan, C. K.; Belliveau, N. M.; Brown, E. M.; Mehrotra, M.; Theriot, J. A.
10.1101/2022.12.27.522042 — cell biology — Posted on 2022-12-27
350 Revisiting chromatin packaging in mouse sperm
Yin, Q.; Yang, C.-H.; Strelkova, O.; Sun, Y. H.; Gopalan, S.; Yang, L.; Dekker, J.; Fazzio, T. G.; Li, X. G.; Gibcus, J.; Rando, O.
10.1101/2022.12.26.521943 — molecular biology — Posted on 2022-12-27
351 Improved genetically encoded fluorescent biosensors for monitoring of intra- and extracellular L-lactate
Nasu, Y.; Aggarwal, A.; Le, G. N. T.; Kamijo, Y.; Boisvert, M.; Paquet, M.-E.; Drobizhev, M.; Podgorski, K.; Campbell, R. E.
10.1101/2022.12.27.522013 — molecular biology — Posted on 2022-12-27
352 Cardiovascular disease causes proinflammatory microvascular changes in the human right atrium
Linna-Kuosmanen, S.; Schmauch, E.; Galani, K.; Ojanen, J.; Boix, C. A.; Örd, T.; Toropainen, A.; Singha, P. K.; Moreau, P. R.; Harju, K.; Blazeski, A.; Segerstolpe, A.; Lahtinen, V.; Hou, L.; Kang, K.; Meibalan, E.; Agudelo, L. Z.; Kokki, H.; Halonen, J.; Jalkanen, J.; Gunn, J.; MacRae, C. A.; Hollmen, M.; Hartikainen, J.; Kaikkonen, M. U.; Garcia-Cardena, G.; Tavi, P.; Kiviniemi, T.; Kellis, M.
10.1101/2021.06.23.449672 — molecular biology — Posted on 2022-12-27
353 The HP1γ epigenetic silencer dampens IFN-γ response at the gut epithelial barrier
Chang, Y.; Mata-Garrido, J.; desterke, C.; Batsche, E.; Hamai, A.; Youssouf, S.; Skurnik, D.; Jalil, A.; Beche, J.-C.; Piaggio, E.; Arbibe, L.; Marchand, Y. C.
10.1101/2022.12.27.522038 — immunology — Posted on 2022-12-27
354 Head motion correction shapes functional network estimates: evidence from healthy and Parkinson's disease cohorts
Saviola, F.; Tambalo, S.; Cabalo, D. G.; Novello, L.; Pierotti, E.; Rabini, G.; Dodich, A.; Turella, L.; Van De Ville, D.; Jovicich, J.
10.1101/2022.12.26.520413 — neuroscience — Posted on 2022-12-27
356 Mesoscale neural effects of transcranial magnetic stimulation
Perera, N. D.; Alekseichuk, I.; Shirinpour, S.; Wischnewski, M.; Linn, G.; Masiello, K.; Butler, B.; Russ, B. E.; Schroeder, C. E.; Falchier, A.; Opitz, A.
10.1101/2022.12.26.521973 — neuroscience — Posted on 2022-12-27
360 Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator
Krumm, B. E.; DiBerto, J. F.; Olsen, R. H. J.; Kang, H. J.; Slocum, S. T.; Zhang, S.; Strachan, R. T.; Slosky, L. M.; Pinkerton, A. B.; Barak, L. S.; Caron, M. G.; Kenakin, T.; Roth, B. L.
10.1101/2022.12.26.521971 — biophysics — Posted on 2022-12-27
362 Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation
Brown, K.; Chew, P. Y.; Ingersoll, S.; Rene Espinosa, J.; Aguirre, A.; Kutateladze, T.; Collepardo-Guevara, R.; Ren, X.
10.1101/2022.12.26.521954 — biochemistry — Posted on 2022-12-27
363 Context-dependence of T-loop mediated long-range RNA tertiary interactions
Hansen, L.; Kletzien, O. A.; Urquijo, M.; Schwanz, L. T.; Batey, R. T.
10.1101/2022.12.26.521914 — biochemistry — Posted on 2022-12-27
367 ISG15-modification of the Arp2/3 complex restricts pathogen spread
Zhang, Y.; Ripley, B. M.; Ouyang, W.; Sturtz, M.; Upton, E.; Luhmann, E.; Vessely, M.; Coloma, R.; Schwery, N.; Anthony, S. M.; Goeken, A.; Moninger, T. O.; Harty, J. T.; Klingelhutz, A. J.; Lundberg, E.; Meyerholz, D. K.; Manicassamy, B.; Stipp, C. S.; Guerra, S.; Radoshevich, L.
10.1101/2022.12.27.522022 — cell biology — Posted on 2022-12-27
368 Differential expression patterns and potential regulatory function of piRNAs in western honey bee larval response to Ascosphaera apis infestation
Sun, M.; Long, Q.; Fan, X.; Wang, Z.; Zhang, K.; Wang, S.; Gao, X.; Guo, S.; Niu, Q.; Jiang, H.; Chen, D.; Fu, Z.; Guo, R.
10.1101/2022.12.27.521978 — molecular biology — Posted on 2022-12-27
369 Effect of Ascosphaera apis infestation on the activities of four antioxidant enzymes in Asian honey bee larval guts
Zhang, K.; Fu, Z.; Fan, X.; Wang, Z.; Wang, S.; Guo, S.; Gao, X.; Zhao, H.; Jing, X.; Zou, P.; Li, Q.; Chen, M.; Chen, D.; Guo, R.
10.1101/2022.12.27.522003 — molecular biology — Posted on 2022-12-27
370 Identification of inosine monophosphate dehydrogenase as a potential target for anti-monkeypox virus agents
Hishiki, T.; Morita, T.; Akazawa, D.; Ohashi, H.; Park, E.-S.; Kataoka, M.; Mifune, J.; Shionoya, K.; Tsuchimoto, K.; Ojima, S.; Azam, A. H.; Nakajima, S.; Yoshikawa, T.; Shimojima, M.; Kiga, K.; Maeda, K.; Suzuki, T.; Ebihara, H.; Takahashi, Y.; Watashi, K.
10.1101/2022.12.26.521968 — microbiology — Posted on 2022-12-27
371 Quantitative analysis of morphogenesis and growth dynamics in an obligate intracellular bacterium
Figueroa-Cuilan, W. M.; Irazoki, O.; Feeley, M.; Smith, E.; Nguyen, T.; Cava, F.; Goley, E. D.
10.1101/2022.12.26.521939 — microbiology — Posted on 2022-12-27
373 Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories
Fang, J.; Castillon, G.; Phan, S.; McArdle, S.; Hariharan, C.; Ellisman, M. H.; Deniz, A. A.; Saphire, E. O.
10.1101/2022.12.27.522024 — microbiology — Posted on 2022-12-27
374 Exceptionally versatile respiratory metabolisms drive metabolite production by diverse gut bacteria
Little, A. S.; Younker, I. T.; Schechter, M. S.; Meheust, R.; Stemczynski, J.; Scorza, K.; Nol Bernardino, P.; Mullowney, M. W.; Sharan, D.; Waligurski, E.; Smith, R.; Ramanswamy, R.; Leiter, W.; Moran, D.; McMillin, M.; Odenwald, M. A.; Iavarone, A. T.; Sidebottom, A. M.; Sundararajan, A.; Pamer, E. G.; Eren, A. M.; Light, S. H.
10.1101/2022.12.26.521950 — microbiology — Posted on 2022-12-27
379 Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
Tamura, T.; Ito, J.; Uriu, K.; Zahradnik, J.; Kida, I.; Nasser, H.; Shofa, M.; Oda, Y.; Lytras, S.; Nao, N.; Itakura, Y.; Deguchi, S.; Suzuki, R.; Wang, L.; Begum, M. M.; Tsuda, M.; Kosugi, Y.; Fujita, S.; Yoshimatsu, K.; Suzuki, S.; Asakura, H.; Nagashima, M.; Sadamasu, K.; Yoshimura, K.; Yamamoto, Y.; Nagamoto, T.; Schreiber, G.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Ikeda, T.; Fukuhara, T.; Saito, A.; Tanaka, S.; Matsuno, K.; Takayama, K.; Sato, K.
10.1101/2022.12.27.521986 — microbiology — Posted on 2022-12-27
380 Tissue protective role of Ganetespib in SARS-CoV-2-infected Syrian golden hamsters
Teixeira Alves, L. G.; Baumgardt, M.; Hoppe, J.; Firsching, T. C.; Adler, J. M.; Mastrobuoni, G.; Grobe, J.; Hoenzke, K.; Kempa, S.; Gruber, A. D.; Hocke, A. C.; Trimpert, J.; Wyler, E.; Landthaler, M.
10.1101/2022.12.27.521979 — microbiology — Posted on 2022-12-27
381 An alpaca-derived nanobody neutralizes the SARS-CoV-2 omicron variant
Modhiran, N.; Lauer, S. M.; Amarilla, A. A.; Hewins, P.; van den Broek, S. I. L.; Low, Y. S.; Thakur, N.; Liang, B.; Nieto, G. V.; Jung, J.; Paramitha, D.; Isaacs, A.; de Sng, J.; Song, D.; Jorgensen, J.; Cheuquemilla, Y.; Burger, J.; Andersen, I. V.; Himelreichs, J.; Jara, R.; MacLoughlin, R.; Miranda-Chacon, Z.; Chana-Cuevas, P.; Kramer, V.; Spahn, C. M. T.; Mielke, T.; Khromykh, A. A.; Munro, T.; Jones, M.; Young, P. R.; Chappell, K.; Bailey, D.; Kjaer, A.; Herth, M. M.; Jurado, K. A.; Schwefel, D.; Rojas-Fernandez, A.; Watterson, D.
10.1101/2022.12.27.521990 — microbiology — Posted on 2022-12-27
382 ESCRT recruitment to mRNA-encoded SARS-CoV-2 spike induces virus-like particles and enhanced antibody responses
Hoffmann, M. A.; Yang, Z.; Huey-Tubman, K. E.; Cohen, A. A.; Gnanapragasam, P. N.; Nakatomi, L. M.; Storm, K. N.; Moon, W. J.; Lin, P. J.; Bjorkman, P. J.
10.1101/2022.12.26.521940 — immunology — Posted on 2022-12-27
385 Single-cell Landscape Analysis of the Human Circulating B Cell Pool under Selective Pressure of Allogeneic Stem Cell Transplantation
Poe, J. C.; Fang, J.; Zhang, D.; Lee, M. R.; DiCioccio, R. A.; Su, H.; Qin, X.; Zhang, J.; Visentin, J.; Bracken, S. J.; Ho, V. T.; Wang, K. S.; Rose, J. J.; Pavletic, S. Z.; Hakim, F. T.; Jia, W.; Suthers, A. N.; Curry-Chisolm, I.; Horwitz, M. E.; Rizzieri, D. A.; McManigle, W.; Chao, N. J.; Cardones, A. R.; Xie, J.; Owzar, K.; Sarantopoulos, S.
10.1101/2022.10.13.512162 — immunology — Posted on 2022-12-27
386 A legacy role for DNA binding of Lon protects against genotoxic stress
Zeinert, R. D.; Ogdahl, J.; Liu, J.; Yang, Q.; Du, Y.; Barros, B. B.; Freddolino, P. L.; Haynes, C.; Chien, P.
10.1101/317677 — microbiology — Posted on 2022-12-27
391 Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study
exRNAQC Consortium, ; Anckaert, J.; Avila Cobos, F.; Decock, A.; Decruyenaere, P.; Deleu, J.; De Preter, K.; De Wever, O.; De Wilde, J.; Dhondt, B.; D'huyvetter, T.; Everaert, C.; Fierro, C.; Helsmoortel, H. H.; Hendrix, A.; Hulstaert, E.; Koster, J.; Kuersten, S.; Mercer, T. R.; Mestdagh, P.; Morlion, A.; Nijs, N.; Nuytens, J.; Philippron, A.; Piofczyk, T.; Poma-Soto, F.; Schoofs, K.; Schroth, G. P.; Thas, O.; Vanden Eynde, E.; Vandesompele, J.; Van Maerken, T.; Van Paemel, R.; Verniers, K.; Verwilt, J.; Yigit, N.
10.1101/2021.05.11.442610 — genomics — Posted on 2022-12-27
394 Superinfection plays an important role in the acquisition of complex Plasmodium falciparum infections among female Anopheles mosquitoes
Berube, S.; Freedman, B.; Menya, D.; Kipkoech, J.; Abel, L.; Lapp, Z.; Taylor, S. M.; O'Meara, W. P.; Obala, A. A.; Wesolowski, A.
10.1101/2022.12.23.521802 — systems biology — Posted on 2022-12-27
395 The nanomechanical fingerprint of colorectal-derived peritoneal metastasis
Lorenc, E.; Varinelli, L.; Chighizola, M.; Brich, S.; Pisati, F.; Guaglio, M.; Baratti, D.; Deraco, M.; Gariboldi, M.; Podesta, A.
10.1101/2022.08.17.504271 — biophysics — Posted on 2022-12-27
396 Epitopes- Based Vaccine Design Against Foot and Mouth Disease SAT2 Serotype from Sudanese Isolate by Using Immunoinformatic Approaches
Habiballa, I. I.; Alhussin, Y. A.; Alhaj, M. O.; Mohamed, S. I.; Elhassan, R. M.; Salim, O. O.; Mustafa, E. M.; Ahmed, M. A.; Mohamed, M. M.; Sirdar, M. M.; Hassan, M. A.
10.1101/2022.12.23.520716 — bioinformatics — Posted on 2022-12-27
398 Bovine serum albumin promotes reactivation of viable but non-culturable Mycobacterium tuberculosis via activation of protein kinase-dependent cell division processes
Morishige, Y.; Murase, Y.; Chikamatsu, K.; Yamada, H.; Aono, A.; Igarashi, Y.; Kamada, K.; Shimomura, Y.; Hosoya, M.; Takaki, A.; Mitarai, S.
10.1101/2021.11.22.468319 — microbiology — Posted on 2022-12-27
399 Apical size and deltaA expression predict adult neural stem cell decisions along lineage progression
Mancini, L.; Guirao, B.; Ortica, S.; Labusch, M.; Cheysson, F.; Bonnet, V.; Phan, M. S.; Herbert, S.; Mahou, P.; Menant, E.; Bedu, S.; Tinevez, J.-Y.; Baroud, C.; Beaurepaire, E.; Bellaiche, Y.; Bally-Cuif, L.; Dray, N.
10.1101/2022.12.26.521937 — neuroscience — Posted on 2022-12-26
400 Molecular characterization of Left-Right symmetry breaking in the mouse embryo
Tyser, R. C. V.; Ibarra-Soria, X.; Pedroza, M.; Miranda, A. M. A.; van den Brand, T. A. H.; Scialdone, A.; Marioni, J.; Srinivas, S.
10.1101/2022.12.26.521947 — developmental biology — Posted on 2022-12-26
403 Independent inhibitory control mechanisms for aggressive motivation and action
Minakuchi, T.; Guthman, E. M.; Acharya, P.; Hinson, J.; Fleming, W.; Witten, I.; Oline, S.; Falkner, A. L.
10.1101/2022.12.26.521956 — neuroscience — Posted on 2022-12-26
404 Reconstructing disease dynamics for mechanistic insights and clinical benefit
Frishberg, A.; Milman, N.; Alpert, A.; Spitzer, H.; Asani, B.; Schiefelbein, J. B.; Priglinger, S. G.; Schultze, J. L.; Theis, F. J.; Shen-Orr, S. S.
10.1101/2021.11.17.468952 — systems biology — Posted on 2022-12-26
406 Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
Moghadasi, S. A.; Heilmann, E.; Khalil, A.; Nnabuife, C.; Kearns, F.; Ye, C.; Moraes, S. N.; Costacurta, F.; Esler, M.; Aihara, H.; von Laer, D.; Martinez-Sobrido, L.; Palzkill, T.; Amaro, R. E.; Harris, R.
10.1101/2022.08.07.503099 — microbiology — Posted on 2022-12-26
407 Adolescent cocaine exposure induces higher sensitivity to cocaine during adulthood through weakening mPFC DUSP1CaMKII
Wei, X.; Chang, J.; Cheng, Z.; Chen, W.; Guo, H.; Liu, Z.; Mai, Y.; Hu, T.; Zhang, Y.; Cai, Q.; Ge, F.; Fan, Y.; Guan, X.
10.1101/2022.08.26.505502 — neuroscience — Posted on 2022-12-26
408 Innovative, rapid, high throughput method for drug repurposing in a pandemic - a case study of SARS-CoV-2 and COVID-19
Bello, S. O.; Yunusa, A.; Adamu, A. A.; Imam, M. U.; Bello, M. B.; Shuaibu, A. B.; Igumbor, E. U.; Habib, Z. G.; Popoola, M. A.; Ochu, C. L.; Bello, A. Y.; Deeni, Y. Y.; Okoye, I.
10.1101/2022.12.25.521651 — pharmacology and toxicology — Posted on 2022-12-26
412 Regulation of Nuclear Transcription by Mitochondrial RNA
Sriram, K.; Qi, Z.; Yuan, D.; Malhi, N. K.; Liu, X.; Calandrelli, R.; Luo, Y.; Jin, S.; Shi, J.; Salas, M.; Dang, R.; Armstrong, B.; Priceman, S. J.; Wang, P.; Liao, J.; Natarajan, R.; Zhong, S.; Chen, Z. B.
10.1101/2022.12.10.519922 — genomics — Posted on 2022-12-26
416 Predictive and robust gene selection for spatial transcriptomics
Covert, I.; Gala, R.; Wang, T.; Svoboda, K.; Sümbül, U.; Lee, S.-I.
10.1101/2022.05.13.491738 — cell biology — Posted on 2022-12-26
418 A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates
Weidenbacher, P. A.- B.; Sanyal, M.; Friedland, N.; Tang, S.; S Arunachalam, P.; Hu, M.; Kumru, O. S.; Morris, M. K.; Fontenot, J.; Shirreff, L.; Do, J.; Cheng, Y.-C.; Vasudevan, G.; Feinberg, M. B.; Villinger, F. J.; Hanson, C.; Joshi, S. B.; Volkin, D. B.; Pulendran, B.; Kim, P. S.
10.1101/2022.12.25.521784 — immunology — Posted on 2022-12-26
419 Longitudinal monitoring of maternal care and maternal neglect
Schuster, L.; Henderson, R.; Sankar, S.; Ananth, D.; Kirk, M.; Leone, P.; Adolph, K. E.; Froemke, R. C.; Mar, A.
10.1101/2022.12.26.521927 — neuroscience — Posted on 2022-12-26
424 Structural insights into human ABCC4 mediated transport of platelet agonist and inhibitor
Chen, Y.; Wang, L.; Hou, W.-T.; Zha, Z.-H.; Xu, K.; Zhou, C.-Z.; Li, Q.; Chen, Y.
10.1101/2022.12.25.521909 — biochemistry — Posted on 2022-12-26
425 Korea4K: whole genome sequences of 4,157 Koreans with 107 phenotypes derived from extensive health check-ups
Jeon, S.; Choi, H.; Jeon, Y.; Choi, W.-H.; Choi, H.; An, K.; Ryu, H.; Bhak, J.; Lee, H.; Kwon, Y.; Ha, S.; Kim, Y. J.; Blazyte, A.; Kim, C.; Kim, Y.; Kang, Y.; Woo, Y. J.; Lee, C.; Seo, J.; Bolser, D.; Biro, O.; Shin, E.-S.; Kim, B. C.; Kim, S.-Y.; Park, J.-H.; Jeon, J.; Jung, D.; Lee, S.; Bhak, J.
10.1101/2022.12.25.521908 — genomics — Posted on 2022-12-26
429 Generation of anti-tumor chimeric antigen receptors incorporating T cell signaling motifs
Balagopalan, L.; Moreno, T.; Qin, H.; Yi, J.; McIntire, K. M. M.; Alvinez, N.; Pallikkuth, S.; Lee, M. E.; Yamane, H.; Tran, A. D.; Youkharibache, P.; Cachau, R. E.; Taylor, N.; Samelson, L. E.
10.1101/2022.12.25.521452 — immunology — Posted on 2022-12-26
432 In Vitro Inhibition of SARS-CoV-2 Infection by Bromhexine hydrochloride
Martins, R.; Ferreira, I.; Jorge, D. M.; Almeida, L.; Souza, J. d. P.; Pontelli, M. C.; Castro, I. A.; Melquiades, T.; Mendes Viana, R. M.; Zamboni, D. S.; Marcato, P.; Arruda, E.
10.1101/2022.12.23.521817 — pharmacology and toxicology — Posted on 2022-12-26
433 Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16
Wang, H.; Rizvi, S. R. A.; Dong, D.; Lou, J.; Wang, Q.; Sopipong, W.; Su, Y.; Najar, F.; Agarwal, P.; Kozielski, F. G.; Haider, S.
10.1101/2022.12.23.521761 — biophysics — Posted on 2022-12-26
435 Structural basis for the ligand promiscuity of the neofunctionalized, carotenoid-binding fasciclin domain protein AstaP
Kornilov, F. D.; Slonimskiy, Y. B.; Lunegova, D. A.; Egorkin, N. A.; Savitskaya, A. G.; Kleymenov, S. Y.; Maksimov, E. G.; Goncharuk, S. A.; Mineev, K. S.; Sluchanko, N. N.
10.1101/2022.12.26.521925 — biochemistry — Posted on 2022-12-26
438 A large-scale serological survey in pets from October 2020 through June 2021 in France shows significantly higher exposure to SARS-CoV-2 in cats
Fritz, M.; Elguero, E.; Becquart, P.; de Riols de Fonclare, D.; Garcia, D.; Beurlet, S.; Denolly, S.; Boson, B.; Rosolen, S. G.; Cosset, F.-L.; Briend-Marchal, A.; Legros, V.; Leroy, E. M.
10.1101/2022.12.23.521567 — microbiology — Posted on 2022-12-26
440 Hematopoiesis and cell growth are differentially regulated by TAL1 isoforms
Sharma, A.; Mistriel-Zerbib, S.; Najar, R. A.; Engal, E.; Bentata, M.; Taqatqa, N.; Dahan, S.; Cohen, K.; Jaffe-Herman, S.; Geminder, O.; Baker, M.; Nevo, Y.; Plaschkes, I.; Kay, G.; Drier, Y.; Berger, M.; Salton, M.
10.1101/2022.11.30.518304 — molecular biology — Posted on 2022-12-26
441 Non-target effects of ten essential oils on the egg parasitoid Trichogramma evanescens
van Oudenhove, L.; Cazier, A.; Fillaud, M.; Lavoir, A.-V.; Fatnassi, H.; Perez, G.; Calcagno, V.
10.1101/2022.01.14.476310 — ecology — Posted on 2022-12-26
442 SUMOylation of the Cardiac Sodium Channel NaV1.5 Modifies Inward Current and Cardiac Excitability
Yoon, J.-Y.; Greiner, A.; Jacobs, J. S.; Kim, Y.-R.; Rasmussen, T. P.; Kutschke, W.; Matasic, D. S.; Vikram, A.; Gaddam, R. R.; Mehdi, H.; Irani, K.; London, B.
10.1101/2022.12.26.521675 — physiology — Posted on 2022-12-26
443 Mapping Pharmacologically-induced Functional Reorganisation onto the Brain's Neurotransmitter Landscape
Luppi, A. I.; Hansen, J. Y.; Adapa, R.; Carhart-Harris, R. L.; Roseman, L.; Timmermann, C.; Golkowski, D.; Ranft, A.; Ilg, R.; Jordan, D.; Bonhomme, V.; Vanhaudenhuyse, A.; Demertzi, A.; Jaquet, O.; Bahri, M. A.; Alnagger, N. L. N.; Cardone, P.; Peattie, A. R. D.; Manktelow, A. E.; de Araujo, D. B.; Sensi, S. L.; Owen, A. M.; Naci, L.; Menon, D. K.; Misic, B.; Stamatakis, E. A.
10.1101/2022.07.12.499688 — neuroscience — Posted on 2022-12-26
449 PROSTATA: Protein Stability Assessment using Transformers
Umerenkov, D.; Shashkova, T. I.; Strashnov, P. V.; Nikolaev, F.; Sindeeva, M.; Ivanisenko, N. V.; Kardymon, O. L.
10.1101/2022.12.25.521875 — bioinformatics — Posted on 2022-12-26
450 Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins
Franck, C.; Patel, K.; Walport, L. J.; Christie, M. T.; Norman, A.; Passioura, T.; Payne, R. J.; Suga, H.; Mackay, J. P.
10.1101/2022.12.25.521885 — biochemistry — Posted on 2022-12-26
451 A semi-field system for quantifying Anopheles gambiae attraction to human scent
Giraldo, D.; Rankin-Turner, S.; Corver, A.; Tauxe, G. M.; Gao, A. L.; Jackson, D. M.; Simubali, L.; Book, C.; Stevenson, J. C.; Thuma, P. E.; Gordus, A.; Mburu, M. M.; Simulundu, E.; McMeniman, C. J.
10.1101/2022.12.25.521702 — animal behavior and cognition — Posted on 2022-12-26
453 Determinants of Motor Neuron Functional Subtypes Important for Locomotor Speed
D'Elia, K. P.; Hameedy, H.; Goldblatt, D.; Frazel, P.; Kriese, M.; Zhu, Y.; Hamling, K. R.; Kawakami, K.; Liddelow, S. A.; Schoppik, D.; Dasen, J. S.
10.1101/2022.12.23.521820 — neuroscience — Posted on 2022-12-26
455 Single-nucleus ATAC-seq elucidates major modules of gene regulation in the development of non-alcoholic fatty liver disease
Takeuchi, F.; Liang, Y.-Q.; Shimizu-Furusawa, H.; Isono, M.; Ang, M. Y.; Mori, K.; Mori, T.; Kakazu, E.; Yoshio, S.; Kato, N.
10.1101/2022.07.12.499681 — genomics — Posted on 2022-12-25
457 Metformin Alleviates Arthrofibrosis in Rat via Fibroblast Metabolic Reprogramming
Zhu, Z.; Gao, S.; Zhu, H.; Chen, Y.; Wu, D.; Chen, Z.; Zou, J.; Wu, X.; Hu, N.; Chen, D.; Huang, W.; Chen, H.
10.1101/2022.07.05.498844 — cell biology — Posted on 2022-12-25
460 Haploid-resolved and chromosome-scale genome assembly in hexa-autoploid sweetpotato (Ipomoea batatas (L.) Lam)
Yoon, U.-H.; Cao, Q.; Shirasawa, K.; Zhai, H.; Lee, T.-H.; Tanaka, M.; Hirakawa, H.; Hahn, J.-H.; Wang, X.; Kim, H. S.; Tabuchi, H.; Zhang, A.; Kim, T.-H.; Nagasaki, H.; Xiao, S.; Okada, Y.; Jeong, J. C.; Nagano, S.; Shin, Y.; Lee, H.-U.; Park, S.-U.; Lee, S. J.; Lee, K.; Yang, J.-W.; Ahn, B. O.; Ma, D.; Takahata, Y.; Kwak, S.-S.; Liu, Q.; Isobe, S.
10.1101/2022.12.25.521700 — genomics — Posted on 2022-12-25
461 Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis
Luo, Q.; Wang, C.; Qiao, S.; Yu, S.; Chen, L.; Kim, S.; Wang, K.; Zheng, J.; Zhang, Y.; Wu, F.; Lei, X.; Lou, J.; Hennig, M.; Im, W.; Miao, L.; Zhou, M.; Huang, Y.
10.1101/2022.12.25.521893 — microbiology — Posted on 2022-12-25
466 Targeting riboswitches with beta-axial substituted cobalamins
Lennon, S. R.; Wierzba, A. J.; Siwik, S. H.; Gryko, D.; Palmer, A. E.; Batey, R. T.
10.1101/2022.12.25.521693 — biochemistry — Posted on 2022-12-25
467 Biosynthesis of Kratom Opioids
Kim, K.; Shahsavarani, M.; Garza-Garcia, J. J. O.; Carlisle, J. E.; Guo, J.; De Luca, V.; Qu, Y.
10.1101/2022.12.25.521902 — biochemistry — Posted on 2022-12-25
469 Reduced progranulin increases tau and alpha-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase
Takahashi, H.; Bhagwagar, S.; Nies, S. H.; Chiasseu, M. T.; Wang, G.; Mackenzie, I. R.; Strittmatter, S. M.
10.1101/2022.12.25.521308 — neuroscience — Posted on 2022-12-25
470 Export of triose phosphate from the chloroplast strongly impacts photosynthetic efficiency and intracellular ROS accumulation in Chlamydomonas
Huang, W.; Krishnan, A.; Plett, A.; Meagher, M.; Linka, N.; Wang, Y.; Ren, B.; Findinier, J.; Redekop, P.; Fakhimi, N.; Kim, R. G.; Karns, D. A.; Boyle, N.; Posewitz, M.; Grossman, A. R.
10.1101/2022.07.25.501471 — plant biology — Posted on 2022-12-25
474 Omicron BA.5 infects human brain organoids and is neuroinvasive and lethal in K18-hACE2 mice
Stewart, R.; Ellis, S. A.; Yan, K.; Dumenil, T.; Tang, B.; Nguyen, W.; Bishop, C. R.; Larcher, T.; Parry, R.; Sullivan, R. K. P.; Lor, M.; Khromykh, A. A.; Meunier, F. A.; Rawle, D. J.; Suhrbier, A.
10.1101/2022.12.22.521696 — microbiology — Posted on 2022-12-25
476 Genomics of turions from the Greater Duckweed reveal its pathways for dormancy and reemergence strategy
Pasaribu, B.; Acosta, K.; Aylward, A.; Abramson, B. W.; Colt, K.; Hartwick, N. T.; Liang, Y.; Shanklin, J.; Michael, T. P.; Lam, E.
10.1101/2022.12.24.521731 — plant biology — Posted on 2022-12-25
479 GWAS meta-analysis of resistance against Piscirickettsia salmonis in Atlantic salmon
Marin-Nahuelpi, R. I.; Fernandes Garcia, B.; Pina-Elgueda, A.; Gallardo-Hidalgo, J.; Lopez, P.; Cichero, D.; Moen, T.; Odegard, J.; Yanez Lopez, J. M.
10.1101/2022.12.24.521873 — genomics — Posted on 2022-12-25
480 Recurrent evolution of small body size and loss of the sword ornament in Northern Swordtail fish
Preising, G. A.; Gunn, T.; Baczenas, J. J.; Pollock, A.; Powell, D. L.; Dodge, T. O.; Machin Kairuz, J. A.; Savage, M. L.; Lu, Y.; Fitschen-Brown, M.; Cummings, M.; Thakur, S.; Tobler, M.; Rios-Cardenas, O.; Morris, M.; Schumer, M.
10.1101/2022.12.24.521833 — evolutionary biology — Posted on 2022-12-25
481 Invasive species modulate the structure and stability of a multilayer mutualistic network.
Vitali, A.; Ruiz-Suarez, S.; Vazquez, D.; Schleuning, M.; Rodriguez-Cabal, M.; Sasal, Y.; Pilosof, S.
10.1101/2022.12.25.521894 — ecology — Posted on 2022-12-25
498 Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging
Liu, L.; Kim, S.; Buckley, M. T.; Reyes, J. M.; Kang, J.; Tian, L.; Wang, T.; Lieu, A.; Mao, M.; Mateo-Rodriguez, C.; Ishak, H.; Jeong, M.; Wu, J. C.; Goodell, M. A.; Brunet, A.; Rando, T. A.
10.1101/2022.01.12.475145 — cell biology — Posted on 2022-12-25
501 Opioid receptor architecture for the modulation of brainstem functions
Hug, N. F.; Mercer Lindsay, N.; McCallum, W. M.; Bryan, J.; Huang, K.; Ochandarena, N.; Tassou, A.; Scherrer, G.
10.1101/2022.12.24.521865 — neuroscience — Posted on 2022-12-24
502 Rhythmic oscillations in the midbrain dopaminergic nuclei in mice
Oberto, V.; Matsumoto, J.; Pompili, M. N.; Todorova, R.; Papaleo, F.; Nishijo, H.; Venance, L.; Vandecasteele, M.; Wiener, S.
10.1101/2022.12.24.521864 — neuroscience — Posted on 2022-12-24
503 Structure of an endogenous mycobacterial MCE lipid transporter
Chen, J.; Fruhauf, A.; Fan, C.; Ponce, J.; Ueberheide, B.; Bhabha, G.; Ekiert, D. C.
10.1101/2022.12.08.519548 — biochemistry — Posted on 2022-12-24
505 Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys
Hyung Woo, J.; Aguirre, C. G.; Bari, B. A.; Tsutsui, K.-I.; Grabenhorst, F.; Cohen, J. Y.; Schultz, W.; Izquierdo, A.; Soltani, A.
10.1101/2022.10.01.510477 — neuroscience — Posted on 2022-12-24
508 Mapping whole brain effects of infrared neural stimulation with positron emission tomography
Meneghetti, M.; Gudmundsen, F.; Jessen, N. S.; Sui, K.; Baun, C.; Palner, M.; Markos, C.
10.1101/2022.12.24.521746 — neuroscience — Posted on 2022-12-24
510 HydRA: Deep-learning models for predicting RNA-binding capacity from protein interaction association context and protein sequence
Jin, W.; Brannan, K. W.; Kapeli, K.; Park, S. S.; Tan, H. Q.; Gosztyla, M. L.; Mujumdar, M.; Ahdout, J.; Henroid, B.; Rothamel, K.; Xiang, J. S.; Wong, L.; Yeo, G. W.
10.1101/2022.12.23.521837 — bioinformatics — Posted on 2022-12-24
511 Visual versus visual-inertial guidance in hawks pursuing terrestrial targets
Kempton, J. A.; Brighton, C. H.; France, L. A.; Klein Heerenbrink, M.; Minano, S.; Shelton, J.; Taylor, G. K.
10.1101/2022.12.24.521635 — animal behavior and cognition — Posted on 2022-12-24
512 An allelic series rare variant association test for candidate gene discovery
McCaw, Z. R.; Somineni, H.; Bereket, M.; Klein, C.; Karaletsos, T.; Casale, F. P.; Koller, D.; Soare, T. W.
10.1101/2022.12.23.521658 — genetics — Posted on 2022-12-24
518 Asymmetric HIV-1 envelope trimers bound to one and two CD4 molecules are intermediates during membrane binding
Li, W.; Nand, E.; Qin, Z.; Grunst, M. W.; Grover, J. R.; Bess, J. W.; Lifson, J. D.; Zwick, M. B.; Tagare, H. D.; Uchil, P. D.; Mothes, W.
10.1101/2022.12.23.521843 — microbiology — Posted on 2022-12-24
519 Release of large synaptic DCV proteins is triggered by Ca2+-independent Rugose-localized complexin phosphorylation
Bulgari, D.; Cavolo, S. L.; Schmidt, B. F.; Buchan, K.; Bruchez, M. P.; Deitcher, D. L.; Levitan, E.
10.1101/2022.12.24.521856 — neuroscience — Posted on 2022-12-24
521 Patient-derived tumoroids of advanced high-grade neuroendocrine neoplasms mimic patient chemotherapy responses and guide the design of personalized combination therapies
April-Monn, S. L.; Detjen, K.; Kirchner, P.; Braeutigam, K.; Trippel, M. A.; Grob, T.; Statzer, C.; Maire, R. S.; Kollar, A.; Chouchane, A.; Kunze, C. A.; Horst, D.; Sadowski, M. C.; Schrader, J.; Marinoni, I.; Wiedenmann, B.; Perren, A.
10.1101/2022.12.10.519855 — cancer biology — Posted on 2022-12-24
522 Optical Genome Mapping for detecting Homologous Recombination Deficiency (HRD) in human breast cancers
Vanhuele, S.; Kirova, Y.; Hamy-Petit, A.-S.; Rapinat, A.; Gentien, D.; Reyal, F.; Vincent-Salomon, A.; Eeckhoutte, A.; Rodrigues, M.; Popova, T.; Stern, M.-H.
10.1101/2022.12.23.521790 — cancer biology — Posted on 2022-12-24
523 Epigenetic reprogramming shapes the cellular landscape of schwannoma
Liu, S. J.; Casey-Clyde, T.; Cho, N. W.; Swinderman, J.; Pekmezci, M.; Dougherty, M. C.; Foster, K.; Chen, W. C.; Villanueva-Meyer, J. E.; Swaney, D. L.; Vasudevan, H. N.; Choudhury, A.; Breshears, J. D.; Lang, U. E.; Eaton, C. D.; Hiam-Galvez, K. J.; Stevenson, E.; Chen, K.-H.; Lien, B. V.; Wu, D.; Braunstein, S. E.; Sneed, P. K.; Magill, S. T.; Lim, D. A.; McDermott, M. W.; Berger, M. S.; Perry, A.; Krogan, N. J.; Hansen, M.; Spitzer, M. H.; Gilbert, L. A.; Theodosopoulos, P. V.; Raleigh, D. R.
10.1101/2022.12.23.521842 — cancer biology — Posted on 2022-12-24
528 The deacetylase dependent and independent role of HDAC3 in cardiomyopathy
Ren, J.; Zeng, Q.; Wu, H.; Liu, X.; Guida, M. C.; Huang, W.; Zhai, Y.; Li, J.; Bodmer, R.; Ocorr, K.; Tang, M.
10.1101/2022.12.23.521758 — physiology — Posted on 2022-12-24
529 Structural pre-training improves physical accuracy of antibody structure prediction using deep learning.
Konczak, J.; Janusz, B.; Mlokosiewicz, J.; Satlawa, T.; Wrobel, S.; Dudzic, P.; Krawczyk, K.
10.1101/2022.12.06.519288 — bioinformatics — Posted on 2022-12-24
531 An annotated chromosome-scale reference genome for Eastern Black-eared Wheatear (Oenanthe melanoleuca)
Peona, V.; Palacios-Gimenez, O. M.; Lutgen, D.; Olsen, R. A.; Alaei Kakhki, N.; Andriopoulos, P.; Bontzorlos, V.; Schweizer, M.; Suh, A.; Burri, R.
10.1101/2022.12.22.521689 — genomics — Posted on 2022-12-24
532 CRISPR/Cas9-based repeat depletion for the high-throughput genotyping of complex plant genomes
Rossato, M.; Marcolungo, L.; De Antoni, L.; Lopatriello, G.; Bellucci, E.; Cortinovis, G.; Frascarelli, G.; Nanni, L.; Bitocchi, E.; Di Vittori, V.; Vincenzi, L.; Lucchini, F.; Bett, K.; Ramsay, L.; Konkin, D. J.; Delledonne, M.; Papa, R.
10.1101/2022.11.22.517518 — genomics — Posted on 2022-12-24
533 MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancer
Zhao, Y.; Luan, R.; Sun, G.; Zhou, B.; Wang, M.; Bai, Y.; Wang, C.; Wang, S.; Zeng, K.; Feng, J.; He, M.; Lin, L.; Wei, Y.; Zhang, Q.
10.1101/2022.12.23.521780 — cell biology — Posted on 2022-12-24
534 Analysis of splicing abnormalities in the white matter of myotonic dystrophy type 1 brain using RNA-sequence
Yoshizumi, K.; Nishi, M.; Igeta, M.; Nakamori, M.; Matsumura, T.; Fujimura, H.; Jinnai, K.; Kimura, T.
10.1101/2022.12.23.521721 — molecular biology — Posted on 2022-12-24
535 Yeasts have evolved divergent enzyme strategies to deconstruct and metabolize xylan
Ravn, J. L.; Sörensen Ristinmaa, A.; Coleman, T.; Larsbrink, J.; Geijer, C.
10.1101/2022.12.22.521714 — microbiology — Posted on 2022-12-24
538 Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement
Aso, Y.; Yamada, D.; Bushey, D.; Hibbard, K.; Sammons, M.; Otsuna, H.; Shuai, Y.; Hige, T.
10.1101/2022.12.21.521497 — neuroscience — Posted on 2022-12-24
540 Catch bond models may explain how force amplifies TCR signaling and antigen discrimination
Choi, H.-K.; Cong, P.; Ge, C.; Natarajan, A.; Liu, B.; Zhang, Y.; Li, K.; Rushdi, M. N.; Chen, W.; Lou, J.; Krogsgaard, M.; Zhu, C.
10.1101/2022.01.17.476694 — biophysics — Posted on 2022-12-24
545 Postural Sway is not affected by estrogen fluctuations during the menstrual cycle
Reschechtko, S.; Nguyen, T. N.; Tsang, M.; Giltvedt, K.; Kern, M.; Hooshmand, S.
10.1101/2022.07.18.500469 — physiology — Posted on 2022-12-23
546 CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer
Tsujino, T.; Takai, T.; Hinohara, K.; Gui, F.; Tsutsumi, T.; Bai, X.; Miao, C.; Feng, C.; Gui, B.; Sztupinszki, S.; Simoneau, A.; Xie, N.; Fazli, L.; Dong, X.; Azuma, H.; Choudhury, A. D.; Mouw, K. W.; Szallasi, Z.; Zou, L.; Kibel, A. S.; Jia, L.
10.1101/2022.04.13.488115 — cancer biology — Posted on 2022-12-23
548 HydRA: Deep-learning models for predicting RNA-binding capacity from protein interaction association context and protein sequence
Jin, W.; Brannan, K. W.; Kapeli, K.; Park, S. S.; Tan, H. Q.; Gosztyla, M. L.; Mujumdar, M.; Ahdout, J.; Henroid, B.; Rothamel, K.; Xiang, J. S.; Wong, L.; Yeo, G. W.
10.1101/2022.12.23.521837 — bioinformatics — Posted on 2022-12-23
549 Detection of horizontal sequence transfer in microorganisms in the genomic era
TALL, M. L.; MBOGNING FONKOU, M. d.; KUETE YIMAGOU, E.; RAOULT, D.; LEVASSEUR, A.
10.1101/2022.12.21.521446 — bioinformatics — Posted on 2022-12-23
550 ChromFormer: A transformer-based model for 3Dgenome structure prediction
Valeyre, H.; Pati, P.; Gossi, F.; Ram Somnath, V.; Martinelli, A. L.; Rapsomaniki, M. A.
10.1101/2022.11.15.516571 — bioinformatics — Posted on 2022-12-23
551 Native Adiponectin Plays a Role in the Adipocyte Mediated Conversion of Fibroblasts to Myofibroblasts
El-Hattab, M. Y.; Sinclair, N.; Liszewski, J. N.; Schhrodt, M. V.; Herrmann, J.; Klingelhutz, A. J.; Sander, E. A.; Ankrum, J. A.
10.1101/2022.12.23.521683 — bioengineering — Posted on 2022-12-23
552 Silicon as a microfluidic material for imaging and incubation of droplets
Lobato-Dauzier, N.; Deteix, R.; Gines, G.; Baccouche, A.; Hapsianto, B. N.; Okumura, S.; Mariette, G.; Belharet, D.; Queste, S.; Jalabert, L.; Denoual, M.; Rondelez, Y.; Toshiyoshi, H.; Fujita, H.; Kim, S. H.; Fujii, T.; Genot, A. J.
10.1101/2022.09.09.507341 — biochemistry — Posted on 2022-12-23
555 Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression in C. elegans
Reilly, D. K.; Schwarz, E. M.; Muirhead, C. S.; Robidoux, A. N.; Antoscheckin, I.; Narayan, A.; Doma, M.; Sternberg, P. W.; Srinivasan, J.
10.1101/2021.10.26.465928 — neuroscience — Posted on 2022-12-23
556 LRRC37B is a species-specific regulator of voltage-gated channels and excitability in human cortical neurons
Libe-Philippot, B.; Lejeune, A.; Wierda, K.; Vlaeminck, I.; Beckers, S.; Gaspariunaite, V.; Bilheu, A.; Nyitrai, H.; Vennekens, K.; Bird, T.; Soto, D.; Dennis, M.; Comoletti, D.; Theys, T.; de Wit, J.; Vanderhaeghen, P.
10.1101/2022.12.21.521423 — neuroscience — Posted on 2022-12-23
557 Reliability of resting-state functional connectivity in the human spinal cord: assessing the impact of distinct noise sources
Kaptan, M.; Horn, U.; Vannesjo, S. J.; Mildner, T.; Weiskopf, N.; Finsterbusch, J.; Brooks, J. C.; Eippert, F.
10.1101/2022.12.23.521768 — neuroscience — Posted on 2022-12-23
558 Application of Machine Learning for Volumetric Analysis of Atherosclerotic Burden
Cartaya, A. E.; Maiocchi, S. L.; Torzone, S. K.; Messinger, G. M.; Bahnson, E. M.
10.1101/2022.12.23.521811 — physiology — Posted on 2022-12-23
560 MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio High Fidelity reads
Uliano-Silva, M.; Gabriel R. N. Ferreira, J.; Krasheninnikova, K.; Darwin Tree of Life Consortium, ; Formenti, G.; Abueg, L.; Torrance, J.; W Myers, G.; Durbin, R.; Blaxter, M.; A. McCarthy, S.
10.1101/2022.12.23.521667 — bioinformatics — Posted on 2022-12-23
561 Combination of Expert Guidelines-based and MachineLearning-based Approaches Leads to Superior Accuracy ofAutomated Prediction of Clinical Effect of Copy Number Variations
Sladecek, T.; Gaziova, M.; Kucharik, M.; Zatkova, A.; Pos, Z.; Pos, O.; Krampl, W.; Tomkova, E.; Hyblova, M.; Minarik, G.; Radvanszky, J.; Budis, J.; Szemes, T.
10.1101/2022.12.23.521405 — bioinformatics — Posted on 2022-12-23
562 ICAT: A Novel Algorithm to Robustly Identify Cell States Following Perturbations in Single Cell Transcriptomes
Hawkins, D. Y.; Zuch, D. T.; Huth, J.; Rodriguez-Sastre, N. C.; McCutcheon, K. R.; Glick, A.; Lion, A. T.; Thomas, C. F.; Descoteaux, A.; Johnson, W. E.; Bradham, C.
10.1101/2022.05.26.493603 — bioinformatics — Posted on 2022-12-23
563 Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons
Gu, W.; Luozhong, S.; Cai, S.; Londhe, K.; Elkasri, N.; Hawkins, R.; Yuan, Z.; Su-Greene, K.; Cruz, M.; Chang, Y.-W.; McMullen, P.; Wu, C.; Seo, C.; Guru, A.; Gao, W.; Sarmiento, T.; Schaffer, C.; Nishimura, N.; Cerione, R.; Warden, M.; Langer, R.; Jiang, S.
10.1101/2022.12.07.518870 — bioengineering — Posted on 2022-12-23
564 Reverse Correlation Uncovers More Complete Tinnitus Spectra
Hoyland, A.; Barnett, N. V.; Roop, B. W.; Alexandrou, D.; Caplan, M.; Mills, J.; Parrell, B.; Chari, D. A.; Lammert, A. C.
10.1101/2022.12.23.521795 — bioengineering — Posted on 2022-12-23
566 Discovery and molecular basis of chloride as an allosteric activator and catalytic inhibitor for Class-D beta-lactamases.
Zhou, Q.; Bell, H.; Catalan, P.; Baumann, P.; Evans, R.; Yang, J.; Zhang, Z.; Zappala, D.; Zhang, Y.; Blackburn, G. M.; He, Y.; Jin, Y.
10.1101/2022.12.20.520813 — biochemistry — Posted on 2022-12-23
572 Paternal methamphetamine exposure induces higher sensitivity to methamphetamine in male offspring through driving mPFC ADRB1CaMKII
Zheng, Y.; Liu, D.; Li, Z.; Guo, H.; Chen, W.; Hu, T.; Zhang, Y.; Li, X.; Zhao, Z.; Cai, Q.; Ge, F.; Fan, Y.; Guan, X.
10.1101/2022.08.19.504512 — neuroscience — Posted on 2022-12-23
576 Restriction of dietary fat, but not carbohydrate, affects brain reward regions in adults with obesity
Darcey, V. L.; Guo, J.; Courville, A.; Gallagher, I.; Avery, J. A.; Simmons, W. K.; Ingeholm, J. E.; Herscovitch, P.; Martin, A.; Hall, K. D.
10.1101/2022.04.19.488800 — neuroscience — Posted on 2022-12-23
577 Motor adaptation does not differ when a perturbation is introduced abruptly or gradually
Bansal, A.; 't Hart, B. M.; Chauhan, U.; Eggert, T.; Straube, A.; Henriques, D.
10.1101/2022.12.22.521654 — neuroscience — Posted on 2022-12-23
580 Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides
Pandi, A.; Adam, D.; Zare, A.; Trinh, V. T.; Schaefer, S. L.; Wiegand, M.; Klabunde, B.; Bobkova, E.; Kushwaha, M.; Foroughijabbari, Y.; Braun, P.; Spahn, C.; Preusser, C.; von Strandmann, E. P.; Bode, H. B.; von Buttlar, H.; Bertrams, W.; Jung, A. L.; Abendroth, F.; Schmeck, B.; Hummer, G.; Vazquez, O.; Erb, T. J.
10.1101/2022.11.19.517184 — synthetic biology — Posted on 2022-12-23
581 Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation
Ramirez Montero, D.; Sanchez, H.; van Veen, E.; van Laar, T.; Solano, B.; Diffley, J. F. X.; Dekker, N. H.
10.1101/2022.12.23.521684 — biophysics — Posted on 2022-12-23
585 Biomimetic human lung alveolar interstitium chip with extended longevity
Man, K.; Liu, J.; Liang, C.; Corona, C.; Story, M. D.; Meckes, B.; Yang, Y.
10.1101/2022.12.23.521822 — bioengineering — Posted on 2022-12-23
586 Expanded Multiplexing on Sensor-Constrained Microfluidic Partitioning Systems
Kota, P. K.; Vu, H.-A.; LeJeune, D.; Han, M.; Syed, S.; Baraniuk, R. G.; Drezek, R. A.
10.1101/2022.12.23.521805 — bioengineering — Posted on 2022-12-23
588 RanGTP regulates the augmin complex
Kraus, J.; Travis, S. M.; King, M. R.; Petry, S.
10.1101/2022.12.23.521824 — biochemistry — Posted on 2022-12-23
595 High-throughput profiling of drug interactions in Gram-positive bacteria
Cacace, E.; Kim, V.; Knopp, M.; Tietgen, M.; Brauer, A.; Inecik, K.; Mateus, A.; Milanese, A.; Torrissen Marli, M.; Mitosch, K.; Selkrig, J.; Brochado, A. R.; Kuipers, O.; Kjos, M.; Zeller, G.; Savitski, M. M.; Göttig, S.; Huber, W.; Typas, A.
10.1101/2022.12.23.521747 — microbiology — Posted on 2022-12-23
598 Test-Retest Reliability of the Human Connectome: An OPM-MEG study
Rier, L.; Michelmann, S.; Ritz, H.; Shah, V.; Hill, R. M.; Osborne, J.; Doyle, C.; Holmes, N.; Bowtell, R.; Brookes, M. J.; Norman, K. A.; Hasson, U.; Cohen, J. D.; Boto, E.
10.1101/2022.12.21.521184 — neuroscience — Posted on 2022-12-23
600 Unraveling the therapeutic mechanism of deep-brain stimulation
van den Boom, B. J. G.; Elhazaz Fernandez, A.; Rasmussen, P. A.; van Beest, E. H.; Parthasarathy, A.; Denys, D.; Willuhn, I.
10.1101/2022.12.23.521799 — neuroscience — Posted on 2022-12-23
601 DNA primase large subunit is an essential plant gene for geminiviruses, putatively priming viral ss-DNA replication
Siskos, L.; Antoniou, M.; Riado, J.; Enciso, M.; Garcia, C.; Liberti, D.; Esselink, D.; Baranovskiy, A.; Tahirov, T. H.; Visser, R.; Kormelink, R.; Bai, Y.; Schouten, H. J.
10.1101/2022.12.23.521785 — plant biology — Posted on 2022-12-23
602 GDF15 Is Required for Cold-Induced Thermogenesis and Contributes to Improve Systemic Metabolic Health Following Loss of OPA1 in Brown Adipocytes
Jena, J.; Pena, L. M. G.; Weatherford, E. T.; Marti, A.; Bjorkman, S. H.; Kato, K.; Koneru, J.; Chen, J. H.; Seeley, R.; Abel, E. D.; Pereira, R. O.
10.1101/2022.12.23.521796 — physiology — Posted on 2022-12-23
607 Genetic architecture of inter-specific and -generic grass hybrids by network analysis on multi-omics data
Bornhofen, E.; Fe, D.; Nagy, I.; Lenk, I.; Greve, M.; Didion, T.; Jensen, C. S.; Asp, T.; Janss, L.
10.1101/2022.12.23.521625 — genetics — Posted on 2022-12-23
609 What doesn't kill you makes you live longer - Longevity of a social host linked to parasite proteins
Hartke, J.; Ceron-Noriega, A.; Stoldt, M.; Sistermans, T.; Kever, M.; Fuchs, J.; Butter, F.; Foitzik, S.
10.1101/2022.12.23.521666 — evolutionary biology — Posted on 2022-12-23
611 ROS signaling-induced mitochondrial Sgk1 regulates epithelial cell plasticity
Li, Y.; Liu, C.; Rolling, L.; Sikora, V.; Chen, Z.; Gurwin, J.; Barabell, C.; Lin, J.; Duan, C.
10.1101/2022.12.23.521432 — cell biology — Posted on 2022-12-23
613 The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes
van der Meij, A.; Elsayed, S. S.; Du, C.; Willemse, J.; Wood, T. M.; Martin, N. I.; Raaijmakers, J. M.; van Wezel, G.
10.1101/2022.12.23.521753 — microbiology — Posted on 2022-12-23
618 Development of a shortwave infrared (SWIR) sinuscope for the detection of cerebrospinal fluid (CSF) leaks
Klein, T. W.; Yang, S.; Tusty, M. A.; Nayak, J. V.; Chang, M. T.; Bruns, O. T.; Bischof, T. S.; Valdez, T. A.
10.1101/2022.12.22.520937 — bioengineering — Posted on 2022-12-23
620 Optimized CRISPR guide RNA library cloning reduces skew and enables more compact genetic screens
Heo, S.-J.; Enriquez, L. D.; Federman, S.; Chang, A. Y.; Mace, R.; Sevade, K.; Nguyen, P.; Litterman, A. J.; Shafer, S.; Przybyla, L.; Chow, E. D.
10.1101/2022.12.22.521524 — genomics — Posted on 2022-12-23
622 Cycad phylogeny predicts host plant use of Eumaeus butterflies
Sierra, L.; Valencia-Montoya, W. A.; Lopez-Gallego, C.; Calonje, M.; Robbins, R.; Rosser, N.; Pierce, N. E.
10.1101/2022.12.23.521643 — evolutionary biology — Posted on 2022-12-23
625 Vessel Metrics: A python based software tool for automated analysis of vascular structure in confocal imaging
McGarry, S. D.; Adjekukor, C.; Ahuja, S.; Greysson-Wong, J.; Vien, I.; Rinker, K. D.; Childs, S. J.
10.1101/2022.12.22.521670 — developmental biology — Posted on 2022-12-23
626 Germline-specific role for unconventional components of the γ-tubulin complex in Caenorhabditis elegans
Haruta, N.; Sumiyoshi, E.; Honda, Y.; Terasawa, M.; Uchiyama, C.; Toya, M.; Kubota, Y.; Sugimoto, A.
10.1101/2022.12.23.521729 — cell biology — Posted on 2022-12-23
627 CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin
van Schie, J. J. M.; de Lint, K.; Molenaar, T. M.; Moronta Gines, M.; Balk, J. A.; Rooimans, M. A.; Roohollahi, K.; Pai, G. M.; Borghuis, L.; Ramadhin, A. R.; Dorsman, J. C.; Wendt, K. S.; Wolthuis, R. M. F.; de Lange, J.
10.1101/2022.12.23.521474 — molecular biology — Posted on 2022-12-23
630 A combined DTI-fMRI approach for optimizing the delineation of posteromedial vs. anterolateral entorhinal cortex
Syversen, I. F.; Reznik, D.; Witter, M. P.; Kobro-Flatmoen, A.; Navarro Schroder, T.; Doeller, C. F.
10.1101/2022.12.23.520976 — neuroscience — Posted on 2022-12-23
631 Using the DNA methylation profile of the stress driver gene FKBP5 for chronic pain diagnosis
Maiaru, M.; Acton, R. J.; Wozniak, E. L.; Mein, C. A.; Bell, C. G.; Geranton, S. M.
10.1101/2022.12.22.521573 — neuroscience — Posted on 2022-12-23
634 Broader functions of TIR domains in Arabidopsis immunity
Jacob, P.; Hige, J.; Song, L.; Bayless, A.; Russ, D.; Bonardi, V.; El-Kasmi, F.; Wunsch, L.; Yang, Y.; Fitzpatrick, C. R.; McKinney, B. J.; Nishimura, M. T.; Grant, M. R.; Dangl, J. L.
10.1101/2022.12.23.521769 — plant biology — Posted on 2022-12-23
635 Combination of transcriptomic, proteomic and degradomic profiling reveals common and distinct patterns of pathogen-induced cell death in maize
Barghahn, S.; Saridis, G.; Mantz, M.; Meyer, U.; Mellueh, J. C.; Misas Villamil, J. C.; Huesgen, P. F.; Doehlemann, G.
10.1101/2022.12.23.521742 — plant biology — Posted on 2022-12-23
636 Single-cell analysis maps distinct cellular responses to rhizobia and identifies the novel infection regulator SYMRKL1 in Lotus japonicus
Frank, M.; Fechete, L. I.; Tedeschi, F.; Nadzieja, M.; Norgaard, M. M. M.; Montiel, J.; Andersen, K. R.; Schierup, M. H.; Reid, D.; Andersen, S. U.
10.1101/2022.12.23.521739 — plant biology — Posted on 2022-12-23
637 Unbalancing cAMP and Ras/MAPK pathways as a therapeutic strategy for cutaneous neurofibromas
Mazuelas, H.; Magallon-Lorenz, M.; Uriarte-Arrazola, I.; Negro, A.; Rosas, I.; Blanco, I.; Castellanos, E.; Lazaro, C.; Gel Moreno, B.; Carrio, M.; Serra, E.
10.1101/2022.12.23.521754 — cancer biology — Posted on 2022-12-23
638 Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
Cao, L.; Ruiz Buendia, G. A.; Fournier, N.; Liu, Y.; Armand, F.; Hamelin, R.; Pavlou, M.; Radtke, F.
10.1101/2022.12.23.521745 — cancer biology — Posted on 2022-12-23
643 Gap-free nuclear and mitochondrial genomes of Fusarium verticillioides strain HN2
Wei, Y.; Haoyu, Z.; Lei, Y.; Qun, Y.; Le, S.; Jianyu, W.; Zhibing, L.; Guotian, L.
10.1101/2022.12.22.521711 — genomics — Posted on 2022-12-23
644 Whole-genome sequencing reveals diverse mechanisms underlying quantitative pathogenicity and host adaptation in a fungal plant pathogen
AMEZROU, R.; DUCASSE, A.; COMPAIN, J.; LAPALU, N.; PITARCH, A.; DUPONT, L.; CONFAIS, J.; GOYEAU, H.; KEMA, G. H.; CROLL, D.; AMSELEM, J.; SANCHEZ-VALLET, A.; MARCEL, T. C.
10.1101/2022.12.23.521735 — genomics — Posted on 2022-12-23
650 The phylogenetic history of the Gorteria diffusa radiation sheds light on the origins of plant sexual deception
Delahaie, B.; Mellers, G.; Kellenberger, R. T.; Fernandez-Mazuecos, M.; Fattorini, R.; Brockington, S. F.; Ellis, A. G.; Glover, B. J.
10.1101/2022.12.22.521170 — evolutionary biology — Posted on 2022-12-23
651 Fibroblasts-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis
Burgy, O.; Mayr, C. H.; Ballester Llobell, B.; Sengupta, A.; Schenesse, D.; Coughlan, C.; Parimon, T.; Chen, P.; Lindner, M.; Hilgendorff, A.; Mann, M.; Yildirim, A. O.; Eickelberg, O.; Lehmann, M.; Schiller, H. B.; Burgstaller, G.; Königshoff, M.
10.1101/2022.12.22.521499 — cell biology — Posted on 2022-12-23
653 Golgi apposition promotes the generation of specialized lysosomes in differentiated keratinocytes
Mahanty, S.; Bergam, P.; Belapurkar, V.; Eluvathingal, L.; Gupta, N.; Nair, D.; Raposo, G.; Gangi Setty, S. R.
10.1101/2022.12.22.521712 — cell biology — Posted on 2022-12-23
655 WUREN: Whole-modal fUsion Representation for protein interaction interfacE predictioN
Xiaodong, W.; Xiangrui, G.; Xuezhe, F.; Zhe, H.; Mengcheng, Y.; Tianyuan, W.; XIaolu, H.; Lipeng, L.
10.1101/2022.12.22.521634 — molecular biology — Posted on 2022-12-23
657 Impact of cannabis use on immune cell populations and the viral reservoir in people with HIV on suppressive antiretroviral therapy.
Falcinelli, S. D.; Cooper-Volkheimer, A. D.; Semenova, L.; Wu, E.; Richardson, A.; Ashokkumar, M.; Margolis, D. M.; Archin, N.; Rudin, C.; Murdoch, D. M.; Browne, E. P.
10.1101/2022.12.22.521628 — microbiology — Posted on 2022-12-23
659 Tumor Microenvironment Cellular Crosstalk Predicts Response to Adoptive TIL Therapy in Melanoma
Barras, D.; Ghisoni, E.; Chiffelle, J.; Orcurto, A.; Dagher, J.; Fahr, N.; Benedetti, F.; Crespo, I.; Zimmermann, S.; Duran, R.; Imbimbo, M.; Ochoa De Olza, M.; Navarro, B.; Homiscko, K.; Bobisse, S.; Labes, D.; Tsourti, Z.; Andriakopoulou, C.; Herrera, F.; Grimm, A.; Morotti, M.; Petremand, R.; Dummer, R.; Berthod, G.; Bassani-Sternberg, M.; Schaefer, N.; Prior, J. O.; Matter, M.; Demartines, N.; Aedo, V.; Dromain, C.; Tissot, S.; Corria-Osorio, J.; Kandalaft, L. E.; Pittet, M.; Gottardo, R.; Sempoux, C.; Michelin, O.; Dafni, U.; Trueb, L.; Harari, A.; Dangaj Laniti, D.; Coukos, G.
10.1101/2022.12.23.519261 — immunology — Posted on 2022-12-23
662 Extracellular vesicle-associated cholesterol dictates the regenerative functions of macrophages in the brain
Vanherle, S.; Guns, J.; Loix, M.; Mingneau, F.; Dierckx, T.; Vangansewinkel, T.; Wolfs, E.; Pincela Lins, P.; Bronckaers, A.; Lambrichts, I.; Dehairs, J.; Swinnen, J. V.; Verberk, S. G. S.; Haidar, M.; Hendriks, J. J. A.; Bogie, J. F. J.
10.1101/2022.12.23.521775 — neuroscience — Posted on 2022-12-23
663 A cornichon protein controls polar localization of the PINA auxin transporter in Physcomitrium patens
Yanez-Dominguez, C.; Lagunas-Gomez, D.; Torres-Cifuentes, D. M.; Bezanilla, M.; Pantoja, O.
10.1101/2022.12.22.521699 — plant biology — Posted on 2022-12-23
666 Pheromone-dependent olfaction bidirectionally regulates muscle extracellular vesicles formation
Banasiak, K.; Szczepanska, A.; Kołodziejska, K.; Ibrahim, A. T.; Pokrzywa, W.; Turek, M.
10.1101/2022.12.22.521669 — physiology — Posted on 2022-12-23
668 Dystrophin is a mechanical tension modulator
Hofemeier, A. D.; Muenker, T. M.; Herkenrath, F.; Ristau, M.; Brandt, M.; Shahriyari, M.; Tiburcy, M.; Zimmermann, W. H.; Lenz, C.; Mamchaoui, K.; Bigot, A.; Gilbert, P. M.; Betz, T.
10.1101/2022.12.23.521750 — biophysics — Posted on 2022-12-23
673 Effects of Food Addition and Helminth Removal on Space Use and Spatial Overlap in Wild Rodent Populations
Mistrick, J.; Kitchen, S. M.; Veitch, J. S. M.; Clague, S.; Newman, B. C.; Hall, R. J.; Budischak, S. A.; Forbes, K. M.; Craft, M. E.
10.1101/2022.12.22.521674 — ecology — Posted on 2022-12-23
677 Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults
Schott, B. H.; Soch, J.; Kizilirmak, J. M.; Schütze, H.; Assmann, A.; Maass, A.; Ziegler, G.; Sauvage, M.; Richter, A.
10.1101/2022.12.22.521668 — neuroscience — Posted on 2022-12-23
679 Neurodesk: An accessible, flexible, and portable data analysis environment for reproducible neuroimaging
Renton, A. I.; Dao, T. T.; Abbott, D. F.; Bollmann, S.; Campbell, M. E. J.; Chang, J.; Close, T. G.; Eckstein, K.; Egan, G. F.; Evas, S.; Garner, K. G.; Garrido, M. I.; Hannan, A. J.; Huber, R.; Johnstone, T.; Kaczmarzyk, J. R.; Kasper, L.; Kuhlmann, L.; Lou, K.; Lyons, P.; Mattingley, J. B.; Narayanan, A.; Pestilli, F.; Puce, A.; Ribeiro, F. L.; Rogasch, N. C.; Shaw, T. B.; Sowman, P. F.; Spitz, G.; Stewart, A.; Sullivan, R. P.; White, D. J.; Ye, X.; Zhu, J. D.; Narayanan, A.; Bollmann, S.
10.1101/2022.12.23.521691 — neuroscience — Posted on 2022-12-23
680 Tau depletion in human neurons mitigates A beta-driven toxicity
Ng, B.; Vowles, J.; Beccano-Kelly, D.; Stefana, M. I.; O'Brien, D. P.; Bengoa-Vergniory, N.; Betherat, F.; Abey, A.; Carling, P.; Kilfeather, P.; Todd, J. A.; Caffrey, T. M.; Connor-Robson, N.; Cowley, S. A.; Wade-Martins, R.
10.1101/2022.12.23.521772 — neuroscience — Posted on 2022-12-23
684 Biologically plausible phosphene simulation forthe differentiable optimization of visual corticalprostheses
van der Grinten, M. L.; de Ruyter van Steveninck, J.; Lozano, A.; Pijnacker, L.; Rueckauer, B.; Roelfsema, P.; van Gerven, M.; van Wezel, R.; Guclu, U.; Gucluturk, Y.
10.1101/2022.12.23.521749 — neuroscience — Posted on 2022-12-23
685 Neuronal-immune Axis Alters Pain and Sensory Afferent Damage During Dental Pulp Injury
Erdogan, O.; Michot, B.; Xia, J.; Alabdulaaly, L.; Yesares Rubi, P.; Chiu, I.; Gibbs, J. L.
10.1101/2022.12.23.521695 — neuroscience — Posted on 2022-12-23
686 ZBTB20 is Essential for Cochlear Maturation and Hearing in Mice
Xie, Z.; Ma, X.; Bai, Q.; Tang, J.; Sun, J.; Jiang, F.; Guo, W.; Wang, C.; Yang, R.; Wen, Y.; Wang, F.; Chen, Y.; Zhang, H.; He, D. Z.; Kelley, M. W.; Yang, S.; Zhang, W. J.
10.1101/2022.12.23.521726 — developmental biology — Posted on 2022-12-23
693 Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 Omicron sub-lineages
Touret, F.; Giraud, E.; Bourret, J.; Donati, F.; Tran-Rajau, J.; Chiaravalli, J.; Lemoine, F.; Agou, F.; Simon-Loriere, E.; Van Der Werf, S.; de Lamballerie, X.
10.1101/2022.12.22.521201 — microbiology — Posted on 2022-12-23
695 Serine-129 phosphorylation of α-synuclein is a trigger for physiologic protein-protein interactions and synaptic function
Parra-Rivas, L. A.; Madhivanan, K.; Wang, L.; Boyer, N. P.; Prakashchand, D. D.; Aulston, B. D.; Pizzo, D. P.; Branes-Guerrero, K.; Tang, Y.; Das, U.; Scott, D. A.; Rangamani, P.; Roy, S.
10.1101/2022.12.22.521485 — neuroscience — Posted on 2022-12-23
696 Motor adaptation does not differ when a perturbation is introduced abruptly or gradually
Bansal, A. T.; 't Hart, B. M.; Cauchan, U.; Eggert, T.; Straube, A.; Henriques, D.
10.1101/2022.12.22.521654 — neuroscience — Posted on 2022-12-23
702 Rational design of chemically controlled antibodies and protein therapeutics
Marchand, A.; Bonati, L.; Shui, S.; Scheller, L.; Gainza, P.; Rosset, S.; Georgeon, S.; Tang, L.; Correia, B.
10.1101/2022.12.22.521584 — bioengineering — Posted on 2022-12-23
703 Deep Generative Design of Epitope-Specific Binding Proteins by Latent Conformation Optimization
Eguchi, R. R.; Choe, C. A.; Parekh, U.; Khalek, I. S.; Ward, M. D.; Vithani, N.; Bowman, G. R.; Jardine, J. G.; Huang, P.
10.1101/2022.12.22.521698 — biochemistry — Posted on 2022-12-23
705 The pathological solidification of FUS-RNA condensates is inhibited by performing a protein domain reconstruction in FUS
Blazquez, S.; Sanchez-Burgos, I.; Ramirez, J.; Higginbotham, T.; Conde, M. M.; Collepardo-Guevara, R.; Tejedor, A. R.; Espinosa, J. R.
10.1101/2022.12.14.520383 — biophysics — Posted on 2022-12-23
706 Differential effect of climate on structural and biochemical plant traits
Thakur, D.; Hadincov, V.; Schnablova, R.; Synkova, H.; Haisel, D.; Wilhelmova, N.; Dostalek, T.; Munzbergova, Z.
10.1101/2022.07.18.500466 — ecology — Posted on 2022-12-23
707 RNF43 mutations facilitate mucinous colorectal cancer metastasis via formation of a tumour-intrinsic niche
Bugter, J. M.; El Bouazzaoui, L.; Kucukkose, E.; Hong, Y.; Sprangers, J.; Jordens, I.; Fenderico, N.; Gonzalez, D. M.; van Boxtel, R.; Suijkerbuijk, S. J. E.; Tejpar, S.; Snippert, H. J. G.; Kranenburg, O.; Maurice, M. M.
10.1101/2022.12.22.521159 — cancer biology — Posted on 2022-12-23
708 Best: A Tool for Characterizing Sequencing Errors
Liu, D.; Belyaeva, A.; Shafin, K.; Chang, P.-C.; Carroll, A.; Cook, D.
10.1101/2022.12.22.521488 — bioinformatics — Posted on 2022-12-23
709 Lab evolution, transcriptomics, and modeling reveal mechanisms of paraquat tolerance
Rychel, K.; Tan, J.; Patel, A.; Lamoureux, C.; Hefner, Y.; Szubin, R.; Johnsen, J.; Mohamed, E. T. T.; Phaneuf, P. V.; Anand, A.; Olson, C. A.; Park, J. H.; Sastry, A. V.; Yang, L.; Feist, A. M.; Palsson, B. O.
10.1101/2022.12.20.521246 — systems biology — Posted on 2022-12-23
710 Glyco-engineered pentameric SARS-CoV-2 IgMs show superior activities compared to IgG1 orthologues
Kallolimath, S.; Palt, R.; Föderl-Höbenreich, E.; Sun, L.; Chen, Q.; Pruckner, F.; Eidenberger, L.; Strasser, R.; Zatloukal, K.; Steinkellner, H.
10.1101/2022.12.22.521646 — molecular biology — Posted on 2022-12-23
713 Structural and functional properties of a plant NRAMP related aluminum transporter
Ramanadane, K.; Liziczai, M.; Markovic, D.; Straub, M. S.; Rosalen, G. T.; Udovcic, A.; Dutzler, R.; Manatschal, C.
10.1101/2022.12.21.521437 — biophysics — Posted on 2022-12-23
715 SARS-CoV-2 Omicron subvariants evolved to promote further escape from MHC-I recognition
Moriyama, M.; Lucas, C.; Monteiro, V. S.; Yale SARS-CoV-2 Genomic Surveillance Initiative, ; Iwasaki, A.
10.1101/2022.05.04.490614 — microbiology — Posted on 2022-12-23
716 Identification of novel coloboma candidate genes through conserved gene expression analyses across four vertebrate species
Trejo-Reveles, V.; Owen, N.; Chan, B. H. C.; Toms, M.; Schoenebeck, J. J.; Moosajee, M.; Rainger, J.
10.1101/2022.12.22.521600 — genetics — Posted on 2022-12-22
718 Nf1 deficiency accelerates mammary development and promotes luminal-basal plasticity
Tovar, E. A.; Arumugam, M.; Essenburg, C. J.; Dischinger, P. S.; Grit, J. L.; Callaghan, M.; Sheridan, R. T. C.; Turner, L.; Esquibel, C. R.; Feenstra, K.; Madaj, Z.; Beddows, I.; Graveel, C. R.; Steensma, M. R.
10.1101/2022.12.22.520633 — cancer biology — Posted on 2022-12-22
719 Age-associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex
Frey, T. M.; Murakami, T.; Maki, K.; Kawaue, T.; Sugai, A.; Nakazawa, N.; Adachi, T.; Kengaku, M.; Ohki, K.; Gotoh, Y.; Kishi, Y.
10.1101/2022.08.22.504704 — cell biology — Posted on 2022-12-22
720 Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome
Yagi, H.; Akazawa, H.; Liu, Q.; Umei, M.; Kadowaki, H.; Matsuoka, R.; Shindo, A.; Okamura, S.; Saga-Kamo, A.; Takeda, N.; Komuro, I.
10.1101/2022.12.21.521508 — pharmacology and toxicology — Posted on 2022-12-22
721 Single-cell atlas of bronchoalveolar lavage from preschool cystic fibrosis reveals new cell phenotypes
Maksimovic, J.; Shanthikumar, S.; Howitt, G.; Hickey, P. F.; Ho, W.; Anttila, C.; Brown, D. V.; Senabouth, A.; Kaczorowski, D.; Amann-Zalcenstein, D.; Powell, J. E.; Ranganathan, S.; Oshlack, A.; Neeland, M. R.
10.1101/2022.06.17.496207 — systems biology — Posted on 2022-12-22
722 Vascular ultrasound for in vivo assessment of arterial pathologies in a murine model of atherosclerosis and aortic aneurysm
Hof, A.; Guthoff, H.; Ahdab, M.; Landerer, M.; Schaekel, J.; Niehues, J.; Schorscher, M.; Winkels, H.; Geissen, S.; Adam, M.; Mollenhauer, M.; Mehrkens, D.
10.1101/2022.12.22.521641 — physiology — Posted on 2022-12-22
723 Full site-specific addressability in DNA origami-templated silica nanostructures
Wassermann, L. M.; Scheckenbach, M.; Baptist, A. V.; Glembockyte, V.; Heuer-Jungemann, A.
10.1101/2022.12.22.521222 — biophysics — Posted on 2022-12-22
727 A Phylogenomic Assessment of Processes Underpinning Convergent Evolution in Open-Habitat Chats
Alaei Kakhki, N.; Schweizer, M.; Lutgen, D.; Bowie, R. C. K.; Shirihai, H.; Suh, A.; Schielzeth, H.; Burri, R.
10.1101/2022.06.21.496980 — evolutionary biology — Posted on 2022-12-22
730 APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction
Wynne, M. E.; Ogunbona, O.; Lane, A. R.; Gokhale, A.; Zlatic, S. A.; Xu, C.; Wen, Z.; Duong, D.; Rayaprolu, S.; Ivanova, A.; Ortlund, E. A.; Dammer, E. B.; Seyfried, N. T.; Roberts, B. R.; Crocker, A.; Shanbhag, V.; Petris, M.; Senoo, N.; Kandasamy, S.; Claypool, S. M.; Barrientos, A.; Wingo, A. P.; Wingo, T. S.; Rangaraju, S.; Levey, A.; Werner, E.; Faundez, V.
10.1101/2022.05.11.491499 — cell biology — Posted on 2022-12-22
731 An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells
Salerno, F.; Howden, A. J.; Matheson, L. S.; Gizlenci, O.; Screen, M.; Lingel, H.; Brunner-Weinzierl, M.; Turner, M.
10.1101/2022.12.22.521580 — immunology — Posted on 2022-12-22
734 Revealing the Neurobiology Underlying Interpersonal Neural Synchronization with Multimodal Data Fusion
Lotter, L. D.; Kohl, S. H.; Gerloff, C.; Bell, L.; Niephaus, A.; Kruppa, J. A.; Dukart, J.; Schulte-Rüther, M.; Reindl, V.; Konrad, K.
10.1101/2022.07.26.501562 — neuroscience — Posted on 2022-12-22
738 Miniscope-LFOV: A large field of view, single cell resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals
Guo, C.; Blair, G. J.; Sehgal, M.; Sangiuliano Jimka, F. N.; Bellafard, A.; Silva, A. J.; Golshani, P.; Basso, M. A.; Blair, H. T.; Aharoni, D.
10.1101/2021.11.21.469394 — neuroscience — Posted on 2022-12-22
741 A Circuit for Secretion-coupled Cellular Autonomy in Multicellular Eukaryotes
Qiao, L.; Sinha, S.; Abd El-Hafeez, A. A.; Lo, I.-C.; Midde, K.; Ngo, T.; Aznar, N.; Lopez-Sanchez, I.; Gupta, V.; Farquhar, M.; Rangamani, P.; Ghosh, P.
10.1101/2021.03.18.436048 — systems biology — Posted on 2022-12-22
742 Systematic multi-trait AAV capsid engineering for efficient gene delivery
Eid, F.-E.; Chen, A. T.; Chan, K. Y.; Huang, Q.; Zheng, Q.; Tobey, I. G.; Pacouret, S.; Brauer, P. P.; Keyes, C.; Powell, M.; Johnston, J.; Zhao, B.; Lage, K.; Tarantal, A. F.; Chan, Y. A.; Deverman, B. E.
10.1101/2022.12.22.521680 — synthetic biology — Posted on 2022-12-22
745 Genetic basis and selection of glyceollin induction in wild soybean
Yasmin, F.; Zhang, H.; Leamy, L.; Wang, B.; Winnike, J.; Reid, R. W.; Brouwer, C. R.; Song, B.-H.
10.1101/2022.12.17.520864 — plant biology — Posted on 2022-12-22
746 Aberrant cell state plasticity mediated by developmental reprogramming precedescolorectal cancer initiation
Bala, P.; Rennhack, J. P.; Aitymbayev, D.; Morris, C. X.; Moyer, S. M.; Duronio, G. N.; Doan, P.; Li, z.; Liang, X.; Hornick, J. L.; Yurgelun, M. B.; Hahn, W.; Sethi, N. S.
10.1101/2022.09.22.509032 — cancer biology — Posted on 2022-12-22
749 Decoding Proteoforms with Single Acid Resolution Using a Sub-nanometer Diameter Pore
Lisauskas, T.; Rayabharam, A.; Murkate, P.; Almonte, L.; Rigo, E.; Robles, J. O.; Dong, Z.; Joseph, J.; Aluru, N. R.; Timp, G.
10.1101/2022.12.22.521660 — biophysics — Posted on 2022-12-22
751 Investigating RNA-RNA interactions through computational and biophysical analysis
Mrozowich, T.; Park, S. M.; Waldl, M.; Henrickson, A.; Tersteeg, S.; Nelson, C. R.; De Klerk, A.; Demeler, B.; Hofacker, I. L.; Wolfinger, M. T.; Patel, T. R.
10.1101/2022.02.01.478553 — biochemistry — Posted on 2022-12-22
753 A central helical fulcrum in eIF2B coordinates allosteric regulation of Integrated Stress Response signaling
Lawrence, R.; Shoemaker, S.; Deal, A.; Sangwan, S.; Anand, A.; Wang, L.; Marqusee, S.; Walter, P.
10.1101/2022.12.22.521453 — biochemistry — Posted on 2022-12-22
754 HEIP1 is required for efficient meiotic crossover implementation and is conserved from plants to humans
Singh, D. K.; Lian, Q.; Durand, S.; Chambon, A.; Hurel, A.; Walkemeier, B.; Solier, V.; Kumar, R.; mercier, r.
10.1101/2022.12.22.521598 — genetics — Posted on 2022-12-22
755 De novo evolution of macroscopic multicellularity
Bozdag, G. O.; Zamani-Dahaj, S. A.; Day, T. C.; Kahn, P. C.; Burnetti, A. J.; Lac, D. T.; Tong, K.; Conlin, P. L.; Balwani, A. H.; Dyer, E. L.; Yunker, P. J.; Ratcliff, W. C.
10.1101/2021.08.03.454982 — evolutionary biology — Posted on 2022-12-22
759 The lncRNA landscape of cardiac resident macrophages and identification of Schlafenlnc as a regulator of macrophage migratory function
Dueck, A.; Althaus, L.; Heise, K.; Esfandyari, D.; Bayguen, S.; Brandes, R. P.; Gagneur, J.; Jae, N.; Knolle, P.; Leisegang, M. S.; Maegdefessel, L.; Meitinger, T.; Petzold, N.; Ramanujam, D.; Sager, H.; Schulz, C.; Theodorakis, E.; Uzonyi, A.; Weinberger, T.; Bader, M.; Schmidt-Supprian, M.; Engelhardt, S.
10.1101/2022.11.30.518576 — cell biology — Posted on 2022-12-22
762 Migration and division in cell monolayers on substrates with topological defects
Kaiyrbekov, K.; Endresen, K.; Sullivan, K.; Chen, Y.; Zheng, Z.; Serra, F.; Camley, B. A.
10.1101/2022.12.22.521493 — cell biology — Posted on 2022-12-22
763 Genetic characterization of the zoonotic parasite Ancylostoma caninum in the central and eastern USA
Quintana, T. A.; Johnson, W. L.; Ritchie, D.; Smith, V.; Martin, K. A.; McMahan, K.; Brewer, M. T.; Jesudoss Chelladurai, J. R. J.
10.1101/2022.12.22.521591 — microbiology — Posted on 2022-12-22
767 The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis
Li, Y.; Gao, J.; Zhao, D.; Guan, X.; Morris, S. C.; Finkelman, F. D.; Huang, H.
10.1101/2022.06.13.495950 — immunology — Posted on 2022-12-22
770 High robustness of cytosolic glutathione redox potential under combined salt and osmotic stress in barley as revealed by the biosensor Grx1-roGFP2
Bohle, F.; Klaus, A.; Tegethof, H.; Schwarzländer, M.; Hochholdinger, F.; Meyer, A. J.; Acosta, I.; Müller-Schüssele, S. J.
10.1101/2022.12.22.521445 — plant biology — Posted on 2022-12-22
772 Lipid Nanoparticle Composition Drives Delivery of mRNA to the Placenta
Young, R. E.; Nelson, K. M.; Hofbauer, S. I.; Vijayakumar, T.; Alameh, M.-G.; Weissman, D.; Papachristou, C.; Gleghorn, J. P.; Riley, R. S.
10.1101/2022.12.22.521490 — bioengineering — Posted on 2022-12-22
773 Targeting Spike Glycans to Inhibit SARS-CoV2 Viral Entry
Guseman, A. J.; Rennick, L. J.; Nambulli, S.; Roy, C. N.; Martinez, D.; Yang, D. T.; Bhinderwhala, F.; Vergara, S.; Baric, R. S.; Ambrose, Z.; Duprex, W. P.; Gronenborn, A. M.
10.1101/2022.12.22.521642 — biochemistry — Posted on 2022-12-22
774 Structural Basis of Prostaglandin Efflux by MRP4
Pourmal, S.; Green, E.; Bajaj, R.; Chemmama, I.; Knudsen, G.; Gupta, M.; Sali, A.; Cheng, Y.; Craik, C.; Kroetz, D.; Stroud, R.
10.1101/2022.12.22.521501 — biochemistry — Posted on 2022-12-22
775 An optimized approach for multiplexing single-nuclear ATAC-seq using oligonucleotide conjugated antibodies
Bera, B. S.; Thompson, T. V.; Sosa, E.; Nomaru, H.; Reynolds, D.; Dubin, R. A.; Maqbool, S. B.; Zheng, D.; Morrow, B. E.; Greally, J. M.; Suzuki, M.
10.1101/2022.12.22.521637 — genomics — Posted on 2022-12-22
776 Migration and division in cell monolayers on substrates with topological defect
Kaiyrbekov, K.; Endresen, K.; Sullivan, K.; Chen, Y.; Zheng, Z.; Serra, F.; Camley, B. A.
10.1101/2022.12.22.521493 — cell biology — Posted on 2022-12-22
778 Conserved NIMA kinases regulate multiple steps of endocytic trafficking
Joseph, B. B.; Naslavsky, N.; Binti, S.; Conquest, S.; Robison, L.; Bai, G.; Grant, B. D.; Caplan, S.; Fay, D.
10.1101/2022.12.22.521653 — cell biology — Posted on 2022-12-22
783 Identification and Elimination of Antifungal Tolerance in Candida auris
Koohi, S. R.; Shankarnarayan, S. A.; Galon, C. M.; Charlebois, D. A.
10.1101/2022.12.22.521687 — microbiology — Posted on 2022-12-22
784 T-cell cellular stress and reticulocyte signatures, but not loss of naive T lymphocytes, characterize severe COVID-19 in older adults
Jergovic, M.; Watanabe, M.; Bhat, R.; Coplen, C. P.; Sonar, S. A.; Wong, R.; Castaneda, Y.; Davidson, L.; Kala, M.; Wilson, R. C.; Twigg, H. L.; Knox, K.; Erickson, H. E.; Weinkauf, C. C.; Bime, C.; Bixby, B. A.; Parthasarathy, S.; Mosier, J. M.; LaFleur, B. J.; Bhattacharya, D.; Nikolich, J. Z.
10.1101/2022.12.21.521463 — immunology — Posted on 2022-12-22
785 Single-cell Sequencing Highlights Heterogeneity and Malignant Progression in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma
Zou, D.-D.; Sun, Y.-Z.; Li, X.-J.; Wu, W.-J.; Xu, D.; He, Y.-T.; Qi, J.; Tu, Y.; Tang, Y.; Tu, Y.-H.; Wang, X.-L.; Li, X.; Lu, F.-Y.; Huang, L.; Long, H.; He, L.; Li, X.
10.1101/2022.12.22.521622 — cancer biology — Posted on 2022-12-22
786 Polarity-driven three-dimensional spontaneous rotation of a cell doublet
Lu, L.; Guyomar, T.; Vagne, Q.; Berthoz, R.; Torres-Sanchez, A.; Lieb, M.; Martin-Lemaitre, C.; van Unen, J.; Honigmann, A.; Pertz, O.; Salbreux, G.; Riveline, D.
10.1101/2022.12.21.521355 — biophysics — Posted on 2022-12-22
788 Three linked opposing regulatory variants under selection associate with IVD
Brown, E. A.; Kales, S.; Boyle, M. J.; Vitti, J.; Kotliar, D.; Schaffner, S. F.; Tewhey, R. S.; Sabeti, P. C.
10.1101/2022.12.22.521605 — genetics — Posted on 2022-12-22
791 Anillin forms linear structures and facilitates furrow ingression after septin and formin depletion
Lebedev, M.; Chan, F.-Y.; Bellessem, J.; Osorio, D. S.; Rackles, E.; Mikeladze-Dvali, T.; Carvalho, A. X.; Zanin, E.
10.1101/2022.12.22.521621 — cell biology — Posted on 2022-12-22
792 Spatial modeling of telomere intra-nuclear distribution reveals non-random organization that varies during cell cycle and depends on LAP2 and BAF
Keller, D.; Stinus, S.; Umlauf, D.; Gourbeyre, E.; Biot, E.; Olivier, N.; Mahou, P.; Beaurepaire, E.; Andrey, P.; Crabbe, L.
10.1101/2022.12.22.521599 — cell biology — Posted on 2022-12-22
793 Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen
Amioka, N.; Wu, C.-H.; Sawada, H.; Ito, S.; Wu, C.; Moorleghen, J. J.; Howatt, D. A.; Kooi, C. W. V.; Daugherty, A.; Lu, H. S.
10.1101/2022.12.22.521618 — molecular biology — Posted on 2022-12-22
794 Folate depletion induces erythroid differentiation through perturbation of de novo purine synthesis
Maynard, A. G.; Pohl, N. K.; Petrova, B.; Wong, A. Y. L.; Wang, P.; Culhane, A. J.; Hirsch, L.; Hoang, N.; Kirkland, O.; Braun, T.; Ducamp, S.; Fleming, M. D.; Li, H.; Kanarek, N.
10.1101/2022.12.22.521608 — molecular biology — Posted on 2022-12-22
795 The inhibitory mechanism of a small protein reveals its role in antimicrobial peptide sensing
Jiang, S.; Steup, L. C.; Kippnich, C.; Lazaridi, S.; Malengo, G.; Lemmin, T.; Yuan, J.
10.1101/2022.12.22.521624 — microbiology — Posted on 2022-12-22
798 Global analysis of the yeast knock-out phenome
Turco, G.; Chang, C.; Wang, R. Y.; Kim, G.; Stoops, E.; Richardson, B.; Sochat, V.; Rust, J.; Oughtred, R.; Thayer, N. H.; Kang, F.; Livstone, M. S.; Heinicke, S.; Schroeder, M.; Dolinski, K. J.; Botstein, D.; Baryshnikova, A.
10.1101/2022.12.22.521593 — systems biology — Posted on 2022-12-22
799 A high-level programming language for generative protein design
Hie, B.; Candido, S.; Lin, Z.; Kabeli, O.; Rao, R.; Smetanin, N.; Sercu, T.; Rives, A.
10.1101/2022.12.21.521526 — synthetic biology — Posted on 2022-12-22
800 Language models generalize beyond natural proteins
Verkuil, R.; Kabeli, O.; Du, Y.; Wicky, B. I.; Milles, L. F.; Dauparas, J.; Baker, D.; Ovchinnikov, S.; Sercu, T.; Rives, A.
10.1101/2022.12.21.521521 — synthetic biology — Posted on 2022-12-22
802 Brassicaceae display diverse photorespiratory carbon recapturing mechanisms
Schluter, U.; Bouvier, J. W.; Guerreiro, R.; Malisic, M.; Kontny, C.; Westhoff, P.; Stich, B.; Weber, A. P. M.
10.1101/2022.12.22.521581 — plant biology — Posted on 2022-12-22
803 Conservation agriculture reduces climate change impact of a popcorn and wheat crop rotation
Guidoboni, M. V.; Duparque, A.; Boissy, J.; Mouny, J.-C.; Auberger, J.; van der Werf, H. M.
10.1101/2022.12.22.521544 — plant biology — Posted on 2022-12-22
805 Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
Hrovatin, K.; Bastidas-Ponce, A.; Bakhti, M.; Zappia, L.; Buttner, M.; Sallino, C.; Sterr, M.; Bottcher, A.; Migliorini, A.; Lickert, H.; Theis, F. J.
10.1101/2022.12.22.521557 — bioinformatics — Posted on 2022-12-22
809 Directed Biosynthesis of Mitragynine Stereoisomers
Schotte, C.; Jiang, Y.; Grzech, D.; Dang, T.; Laforest, L.; Leon, F.; Mottinelli, M.; Nadakuduti, S. S.; McCurdy, C. R.; O'Connor, S. E.
10.1101/2022.12.22.521574 — biochemistry — Posted on 2022-12-22
810 The structural basis of itch receptor MRGPRX1 activation
Gan, B.; Yu, L.; Yang, H.; Jiao, H.; Pang, B.; Chen, Y.; Wang, C.; Lv, R.; Hu, H.; Cao, Z.; Ren, R.
10.1101/2022.12.21.521535 — biochemistry — Posted on 2022-12-22
812 Blood transcriptome analysis suggests an indirect molecular association of early life adversities and adult social anxiety disorder by immune-related signal transduction
Edelmann, S.; Wiegand, A.; Hentrich, T.; Pasche, S.; Schulze-Hentrich, J. M.; Munk, M. H. J.; Fallgatter, A. J.; Kreifelts, B.; Nieratschker, V.
10.1101/2022.12.22.521187 — genomics — Posted on 2022-12-22
813 Retrieving the near-complete genome of a threatened bird from wild frozen samples
Luohao, H.; Jiang, X.; Li, B.; Wu, J.; Shen, J.; Xu, Z.; Zhou, X.; Huang, Z.; Hou, M.; Ou, X.; Xu, L.
10.1101/2022.12.22.521577 — genomics — Posted on 2022-12-22
814 An improved reference of the grapevine genome supports reasserting the origin of the PN40024 highly-homozygous genotype
Velt, A.; Frommer, B.; Blanc, S.; Holtgräwe, D.; Duchene, E.; Dumas, V.; Grimplet, J.; Hugueney, P.; Lahaye, M.; Kim, C.; Matus, J. T.; Navarro-Paya, D.; Orduna, L.; Tello-Ruiz, M. K.; Vitulo, N.; Ware, D.; Rustenholz, C.
10.1101/2022.12.21.521434 — genomics — Posted on 2022-12-22
818 The miR156-targeted SlSBP15 represses tomato shoot branching via modulating auxin transport and interacting with GOBLET and BRANCHED1b
Nogueira, F.; Barrera Rojas, C. H.; Vicente, M. H.; Pinheiro Brito, D. A.; Silva, E.; Lopez, A. M.; Ferigolo, L. F.; do Carmo, R. M.; Silva, C.; Silva, G.; Correa, J.; Notini, M.; Freschi, L.; Cubas, P.
10.1101/2022.12.21.521468 — developmental biology — Posted on 2022-12-22
821 The role of aneuploidy and polyclonality in the adaptation of the Protozoan parasite Leishmania to high drug pressure
Negreira, G. H.; de Groote, R.; van Giel, D.; Monsieurs, P.; Maes, I.; de Muylder, G.; Van den Broeck, F.; Dujardin, J.-C.; Domagalska, M. A.
10.1101/2022.12.22.521483 — molecular biology — Posted on 2022-12-22
822 A quantitative and site-specific atlas of the in vivo citrullinome reveals widespread existence of citrullination
Rebak, A.; Hendriks, I. A.; Buch-Larsen, S. C.; Elsborg, J. D.; Kirsch, R.; Doncheva, N. T.; Jensen, L. J.; Christophorou, M. A.; Nielsen, M. L.
10.1101/2022.12.22.521572 — molecular biology — Posted on 2022-12-22
823 Taxonomic and metabolic diversity of Actinobacteria isolated from faeces of a 28,000-year-old mammoth
van Bergeijk, D. A.; Augustijn, H.; Elsayed, S. S.; Willemse, J.; Carrion, V. J.; Urem, M.; Grigoreva, L. V.; Cheprasov, M.; Grigariev, S.; Wintermans, B.; Budding, A. E.; Spaink, H. P.; Medema, M. H.; van Wezel, G.
10.1101/2022.12.22.521380 — microbiology — Posted on 2022-12-22
824 A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates
Pons, S.; Frapy, E.; Sereme, Y.; Gaultier, C.; Lebreton, F.; Kropec, A.; Danilchanka, O.; Schlemmer, L.; Schrimpf, C.; Allain, M.; Angoulvant, F.; Lecuyer, H.; Bonacorsi, S.; Aschard, H.; Sokol, H.; Cywes-Bentley, C.; John, M.; Guillard, T.; Pier, G.; Roux, D.; Skurnik, D.
10.1101/2022.12.22.521560 — microbiology — Posted on 2022-12-22
825 The Beta secretase BACE1 drives Systemic Sclerosis fibroblasts activation through B-catenin and Notch signalling
Wasson, C. W.; Clavane, E. M.; Ross, R. L.; Migneco, G.; Antinozzi, C.; Brown, J. M. Y.; Di Luigi, L.; McKimmie, C. S.; Del Galdo, F.; Meakin, P. J.
10.1101/2022.12.22.521579 — immunology — Posted on 2022-12-22
828 E/I unbalance and aberrant oscillation dynamics predict preclinical Alzheimer's disease
Javed, E.; Saurez-Mendez, I.; Susi, G.; Verdejo-Roman, J.; Palva, J. M.; Maestu, F.; Palva, S.
10.1101/2022.12.22.521549 — neuroscience — Posted on 2022-12-22
830 Is short sleep bad for the brain? Brain structure and cognitive function in short sleepers
Fjell, A.; Sorensen, O.; Amlien, I. K.; Barre, W.; Bartres-Faz, D.; Boraxbekk, C.-J.; Brandmaier, A.; Demuth, I.; Drevon, C. A.; Ebmeier, K.; Ghisletta, P.; Kievit, R. A.; Kuhn, S. A.; Nyberg, L.; Madsen, K. S.; Sole-Padulles, C.; Vidal-Pineiro, D.; Wagner, G.; Wang, Y.; Watne, L. O.; Walhovd, K. B.
10.1101/2022.12.22.521614 — neuroscience — Posted on 2022-12-22
831 An electrostatic cluster guides Aβ40 fibril formation in cerebral amyloid angiopathy
Crooks, E. J.; Fu, Z.; Irizarry, B. A.; Zhu, X.; Van Nostrand, W. E.; Chowdhury, S.; Smith, S. O.
10.1101/2022.12.22.521588 — neuroscience — Posted on 2022-12-22
833 Weight loss improves skeletal muscle mitochondrial energy efficiency
Ferrara, P. J.; Lang, M. J.; Johnson, J. M.; Watanabe, S.; McLaughlin, K. L.; Maschek, J. A.; Verkerke, A. R.; Siripoksup, P.; Chaix, A.; Cox, J. E.; Fisher-Wellman, K. H.; Funai, K.
10.1101/2022.12.21.521461 — physiology — Posted on 2022-12-22
834 Progressive spreading of DNA methylation in the GSTP1 promoter CpG island across transitions from precursors to invasive prostate cancer
Gupta, H.; Inoue, H.; Nakai, Y.; Nakayama, M.; Jones, T.; Hicks, J.; Kumar, B.; Gurel, M.; Nelson, W. G.; De Marzo, A. M.; Yegnasubramanian, S.
10.1101/2022.12.21.521517 — cancer biology — Posted on 2022-12-22
835 Mutation divergence over space in tumour expansion
Li, H.; Tu, F.; Deng, L.; Yang, Z.; Fu, X.; Wang, L.; GU, D.; Werner, B.; Huang, W.
10.1101/2022.12.21.521509 — cancer biology — Posted on 2022-12-22
837 Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity
Goretzki, B.; Wiedemann, C.; McCray, B. A.; Schaefer, S. L.; Jansen, J.; Tebbe, F.; Mitrovic, S.-A.; Noeth, J.; Donohue, J.; Jeffries, C. M.; Steinchen, W.; Stengel, F.; Sumner, C. J.; Hummer, G.; Hellmich, U. A.
10.1101/2022.12.21.521430 — biophysics — Posted on 2022-12-22
838 CRAM compression: practical across-technologies considerations for large-scale sequencing projects
Al Ali, A.; Kandavel, P. K.; Al Mabrazi, H.; Carvalho, G.; Kusuma, V.; Katagi, G.; Elavalli, S.; Yousif, A.; Akhter, M. R.; Mafofo, J.; Magalhaes, T.; Quilez, J.
10.1101/2022.12.21.521516 — bioinformatics — Posted on 2022-12-22
839 Enhanced Viral Metagenomics with Lazypipe 2
Pljusnin, I.; Vapalahti, O.; Sironen, T.; Kant, R.; Smura, T.
10.1101/2022.12.21.521450 — bioinformatics — Posted on 2022-12-22
840 HAPNEST: efficient, large-scale generation and evaluation of synthetic datasets for genotypes and phenotypes
Wharrie, S.; Yang, Z.; Raj, V.; Monti, R.; Gupta, R.; Wang, Y.; Martin, A.; O'Connor, L. J.; Kaski, S.; Marttinen, P.; Palamara, P. F.; Lippert, C.; Ganna, A.; INTERVENE Consortium,
10.1101/2022.12.22.521552 — bioinformatics — Posted on 2022-12-22
842 How Aberrant N-Glycosylation Can Alter Protein Functionality and Ligand Binding: an Atomistic View
Castelli, M.; Yan, P.; Rodina, A.; Digwal, C. S.; Panchal, P.; Chiosis, G.; Moroni, E.; Colombo, G.
10.1101/2022.12.22.521543 — biochemistry — Posted on 2022-12-22
851 Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy
Wu, R.; Park, J.; Qian, Y.; Shi, Z.; Hu, R.; Yexian Yuan, Y.; Xiong, S.; Wang, Z.; Yan, G.; Ong, S.-G.; Song, Q.; Song, Z.; Mohamed, A.; Xu, P.; He, C.; Arpke, R. W.; Kyba, M.; Shu, G.; Jiang, Q.; Jiang, Y.
10.1101/2022.12.21.521514 — cell biology — Posted on 2022-12-22
856 Dysfunctional Hippocampal-Prefrontal Connectivity without Neuronal Loss Is Associated with Psychotic-Like Behaviors Following Early-Life Seizure
Ruggiero, R. N.; Marques, D. B.; Rossignoli, M. T.; De Ross, J. B.; Prizon, T.; Beraldo, I. J. S.; Bueno-Junior, L. S.; Kandratavicius, L.; Peixoto-Santos, J. E.; Aguiar, C. L.
10.1101/2022.12.21.521438 — neuroscience — Posted on 2022-12-22
857 Genetic inactivation of the USP19 deubiquitinase regulates a-synuclein ubiquitination and inhibits accumulation of Lewy body like aggregates in mice
Schorova, L.; Bedard, N.; Khayachi, A.; Bolivar-Pedroso, J.; Ho, H.-H.; Huynh, J.; Piccirelli, M.; Wang, Y.; Plourde, M.; Luo, W.; Del Cid Pellitero, E.; Schlaifer, I.; Ye, Y.; Durcan, T.; Wing, S. S.
10.1101/2022.12.21.521125 — neuroscience — Posted on 2022-12-22
861 Upper limb rehabilitation after stroke: constraint versus intensive training. A longitudinal case-control study correlating motor performance with fMRI data
Bellaiche, S.; Ibarrola, D.; Redoute, J.; Comte, J.-C.; Medee, B.; Arsenault, L.; Mayel, A.; Revol, P.; Delporte, L.; Cotton, F.; Rode, G.; Rossetti, Y.; Boisson, D.; Beaudoin-Gobert, M.; Luaute, J.
10.1101/2022.12.22.521566 — neuroscience — Posted on 2022-12-22
865 Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Aortic Aneurysm Formation in Marfan Syndrome
Yagi, H.; Akazawa, H.; Liu, Q.; Umei, M.; Kadowaki, H.; Matsuoka, R.; Shindo, A.; Okamura, S.; Saga-Kamo, A.; Takeda, N.; Komuro, I.
10.1101/2022.12.21.521508 — pharmacology and toxicology — Posted on 2022-12-22
866 Sex-biased Yap1 oncogene function
Abdelfattah, N.; Natarajan, S.; Maldonado, J.; Tran, H. N.; McMinimy, R.; Borland, H.; Chen, S.-h.; Camargo, F.; Olson, J.; George, J.; Yun, K.
10.1101/2022.12.21.521494 — cancer biology — Posted on 2022-12-22
869 TrAGEDy: Trajectory Alignment of Gene Expression Dynamics
Laidlaw, R. F.; Briggs, E. M.; Matthews, K. R.; McCulloch, R.; Otto, T. D.
10.1101/2022.12.21.521424 — bioinformatics — Posted on 2022-12-22
871 Decorrelation Time Mapping as an Analysis Tool for Nanobubble-Based Contrast Enhanced Ultrasound Imaging
Wegierak, D.; Cooley, M. B.; Perera, R.; Wultange, W. J.; Gurkan, U.; Kolios, M. C.; Exner, A. A.
10.1101/2022.12.21.521428 — bioengineering — Posted on 2022-12-22
875 Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 locus mismatches associated with long-term renal transplant survival
Sun, Z.; Zhang, Z.; Banu, K.; Gibson, I.; Colvin, R.; Yi, Z.; Zhang, W.; Kumar, B. D.; Pell, J.; Djamali, A.; Gallon, L.; O Connell, P.; He, C.; Pober, J.; Heeger, P.; Menon, M. C.
10.1101/2022.12.21.521481 — genetics — Posted on 2022-12-22
876 Who removes seeds in a heavily urbanized area?
Hueso-Olaya, D.; Rocha-Ortega, M.; Coronel-Arellano, H.; Palacino-Rodriguez, F.; Cordoba-Aguilar, A.
10.1101/2022.12.21.521511 — ecology — Posted on 2022-12-22
881 Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance
Ju, S.; Horien, C.; Shen, X.; Abuwarda, H.; Trainer, A.; Constable, R. T.; Fredericks, C. A.
10.1101/2022.12.21.521314 — neuroscience — Posted on 2022-12-22
882 Physiologic and nanoscale distinctions define glutamatergic synapses in tonic vs phasic neurons
He, K.; Han, Y.; Li, X.; Hernandez, R. X.; Riboul, D. V.; Feghhi, T.; Justs, K. A.; Mahneva, O.; Perry, S.; Macleod, G. T.; Dickman, D.
10.1101/2022.12.21.521505 — neuroscience — Posted on 2022-12-22
883 Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement
Aso, Y.; Yamada, D.; Bushey, D.; Hibbard, K.; Sammons, M.; Otsuna, H.; Shuai, Y.; Hige, T.
10.1101/2022.12.21.521497 — neuroscience — Posted on 2022-12-22
884 Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery
Halu, A.; Decano, J. L.; Matamalas, J.; Whelan, M.; Asano, T.; Kalicharran, N.; Singh, S. A.; Loscalzo, J.; Aikawa, M.
10.1101/2022.12.21.521456 — systems biology — Posted on 2022-12-22
887 PeptideForest: Semisupervised machine learning integrating multiple search engines for peptide identification
Ranff, T.; Dennison, M.; Bedorf, J.; Schulze, S.; Zinn, N.; Bantscheff, M.; van Heugten, J.; Fufezan, C.
10.1101/2022.12.21.521351 — bioinformatics — Posted on 2022-12-22
888 MetaPredict: A machine learning-based tool for predicting metabolic modules in incomplete bacterial genomes
Geller-McGrath, D.; Konwar, K.; Edgcomb, V. P.; Pachiadaki, M.; Roddy, J.; Wheeler, T.; McDermott, J. E.
10.1101/2022.12.21.521254 — bioinformatics — Posted on 2022-12-22
889 Detection of horizontal sequence transfer in microorganisms in the genomic era
TALL, M. L.; Mbogning Fonkou, M. d.; KUETE YIMAGOU, E.; RAOULT, D.; LEVASSEUR, A.
10.1101/2022.12.21.521446 — bioinformatics — Posted on 2022-12-22
890 FERMO: a Dashboard for Streamlined Rationalized Prioritization of Molecular Features from Mass Spectrometry Data
Zdouc, M. M.; Bayona Maldonado, L. M.; Augustijn, H. E.; Soldatou, S.; de Jonge, N. F.; Jaspars, M.; van Wezel, G. P.; Medema, M. H.; van der Hooft, J. J. J.
10.1101/2022.12.21.521422 — bioinformatics — Posted on 2022-12-22
892 Seasonal and daily patterns in known dissolved metabolites in the northwestern Sargasso Sea
Longnecker, K.; Kido Soule, M. C.; Swarr, G. J.; Parsons, R.; Liu, S.; Johnson, W. M.; Widner, B.; Curry, R.; Carlson, C. A.; Kujawinski, E. B.
10.1101/2022.12.21.521480 — biochemistry — Posted on 2022-12-22
894 A chromosome level genome assembly of longnose gar, Lepisosteus osseus
Mallik, R.; Carlson, K.; Wcisel, D. J.; Fisk, M.; Yoder, J. A.; Dornburg, A.
10.1101/2022.12.21.521478 — genomics — Posted on 2022-12-22
895 CHESS 3: an improved, comprehensive catalog of human genes and transcripts based on large-scale expression data, phylogenetic analysis, and protein structure
Varabyou, A.; Sommer, M. J.; Erdogdu, B.; Shinder, I.; Minkin, I.; Chao, K.-H.; Park, S.; Heinz, J.; Pockrandt, C.; Shumate, A.; Rincon, N.; Puiu, D.; Steinegger, M.; Salzberg, S. L.; Pertea, M.
10.1101/2022.12.21.521274 — genomics — Posted on 2022-12-22
899 Establishment of Bovine Trophoblast Stem Cells
Wang, Y.; Yu, L.; Li, J.; Zhu, L.; Ming, H.; Arteaga, C. P.; Sun, H.-X.; Wu, J.; Jiang, Z.
10.1101/2022.12.21.521294 — developmental biology — Posted on 2022-12-22
901 Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults
Raschick, M.; Richter, A.; Fischer, L.; Knopf, L.; Schult, A.; Yakupov, R.; Behnisch, G.; Guttek, K.; Düzel, E.; Dunay, I. R.; Seidenbecher, C. I.; Schraven, B.; Reinhold, D.; Schott, B. H.
10.1101/2022.12.21.521442 — neuroscience — Posted on 2022-12-22
903 A pair of NLRs coordinately modulates NRC3-mediated ETI responses to facilitate age-dependent immunity
Dong, X.; Zhang, X.; Yin, Z.; Li, J.; Xia, C.; Pan, W.; Zhao, Y.; Jing, M.; Liu, J.; Ai, G.; Dou, D.
10.1101/2022.12.20.521344 — plant biology — Posted on 2022-12-22
904 Protection against doxorubicin-induced cardiotoxicity by ergothioneine
Cheah, I. K.; Tang, R. M. Y.; Wang, X.; Sachaphibulkij, K.; Chong, S. Y.; Lim, L. H. K.; Wang, J.-W.; Halliwell, B.
10.1101/2022.12.21.521347 — physiology — Posted on 2022-12-22
905 Friction patterns guide actin network contraction
Colin, A.; Orhant-Prioux, M.; Guerin, C.; Savinov, M.; Scarfone, I.; Roux, A.; De La Cruz, E. M.; Mogilner, A.; Thery, M.; Blanchoin, L.
10.1101/2022.12.21.521384 — biophysics — Posted on 2022-12-22
907 BioNumPy: Fast and easy analysis of biological data with Python
Rand, K. D.; Grytten, I.; Pavlovic, M.; Kanduri, C.; Sandve, G. K.
10.1101/2022.12.21.521373 — bioinformatics — Posted on 2022-12-22
910 Back to the Future: Unleashing your cytometers spectral potential
Walker, R. V.; Hall, C.; Ibrahim, H.; Thompson, S.; Hobson, P.; Crofts, J.-A.; Nobes, P.; Lim, S.; Burpee, T.
10.1101/2022.12.21.521417 — bioengineering — Posted on 2022-12-22
911 Multi-center integrated analysis of non-coding CRISPR screens
Yao, D.; Tycko, J.; Oh, W.; Bounds, L. R.; Gosai, S. J.; Lataniotis, L.; Mackay-Smith, A.; Doughty, B. R.; Gabdank, I.; Schmidt, H.; Youngworth, I.; Andreeva, K.; Ren, X.; Barrera, A.; Luo, Y.; Siklenka, K.; Yardimci, G. G.; The ENCODE4 Consortium, ; Tewhey, R.; Kundaje, A.; Greenleaf, W. J.; Sabeti, P. C.; Leslie, C.; Pritykin, Y.; Moore, J. E.; Beer, M. A.; Gersbach, C.; Reddy, T. E.; Shen, Y.; Engreitz, J. M.; Bassik, M. C.; Reilly, S. K.
10.1101/2022.12.21.520137 — genomics — Posted on 2022-12-22
913 Multiple founding paternal lineages inferred from the newly-developed SNPSeqTyper 639 Y-SNP panel suggested the complex admixture and migration history of Chinese people
He, G.; Wang, M.; Chen, J.; Miao, L.; Zhao, J.; Sun, Q.; Duan, S.; Wang, Z.; Xu, X.; Sun, Y.; Liu, Y.; Liu, J.; Wang, Z.; Liu, C.; Ye, J.; Wang, L.
10.1101/2022.12.20.520342 — genetics — Posted on 2022-12-22
914 GelMap: Intrinsic calibration and deformation mapping for expansion microscopy
Damstra, H. G.; Passmore, J. B.; Serweta, A. K.; Koutlas, I.; Burute, M. P.; Meye, F. J.; Akhmanova, A.; Kapitein, L. C.
10.1101/2022.12.21.521394 — cell biology — Posted on 2022-12-22
915 Inhibition of the DENV2 and ZIKV RNA polymerases by Galidesivir triphosphate measured using a continuous fluorescence assay
Deshpande, S.; Huo, W.; Shrestha, R.; Sparrow, K.; Evans, G. B.; Harris, L. D.; Kingston, R. L.; Bulloch, E. M. M.
10.1101/2022.12.20.521302 — microbiology — Posted on 2022-12-22
916 NEK7 activates the NLRP1 Inflammasome
Muela-Zarzuela, I.; Gallardo-Orihuela, A.; Pino-Angeles, A.; Suarez-Rivero, J. M.; Boy-Ruiz, D.; de Gregorio-Procopio, M.; Oroz, J.; Mbalaviele, G.; Cordero, M. D.
10.1101/2022.12.21.521400 — immunology — Posted on 2022-12-22
917 7-Tesla evidence for columnar and rostral--caudal organization of the human periaqueductal grey response in the absence of threat: a working memory study
Fischbach, A. K.; Satpute, A. B.; Quigley, K. S.; Kragel, P. A.; Bianciardi, M.; Wald, L. L.; Wager, T. D.; Feldman Barrett, L.; Theriault, J. E.
10.1101/2022.12.21.521479 — neuroscience — Posted on 2022-12-22
919 Test-Retest Reliability of the Human Connectome: An OPM-MEG study
Rier, L.; Michelmann, S.; Ritz, H.; Shah, V.; Hill, R. M.; Osborne, J.; Doyle, C.; Holmes, N.; Bowtell, R.; Brookes, M. J.; Norman, K. A.; Hasson, U.; Cohen, J. D.; Boto, E.
10.1101/2022.12.21.521184 — neuroscience — Posted on 2022-12-22
921 Cell wall strengthening by phenylpropanoid dehydrodimers during the plant hypersensitive cell death
Kanawati, B.; Bertic, M.; Moritz, F.; Habermann, F. A.; Zimmer, I.; Mackey, D. M.; Schmitt-Kopplin, P.; Schnitzler, J.-P.; Durner, J.; Gaupels, F.
10.1101/2022.12.20.521293 — plant biology — Posted on 2022-12-22
922 Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic
Stewart, H.; Palmulli, R.; Johansen, K. H.; McGovern, N.; Shehata, O. M.; Carnell, G. W.; Jackson, H. K.; Lee, J. S.; Brown, J. C.; Burgoyne, T. C.; Heeney, J. L.; Okkenhaug, K.; Firth, A.; Peden, A. A.; Edgar, J. R.
10.1101/2021.01.06.425396 — cell biology — Posted on 2022-12-22
923 SARS-CoV-2 causes periodontal fibrosis by deregulating mitochondrial beta-oxidation
Gao, Y.; Kok, W. L.; Sharma, V.; Illsley, C. S.; Hanks, S.; Tredwin, C.; Hu, B.
10.1101/2022.12.15.520561 — molecular biology — Posted on 2022-12-22
924 Coupling of Coastal Activity with Tidal Cycles is Stronger in Tool-using Capuchins (Cebus capucinus imitator)
Goldsborough, Z.; Crofoot, M. C.; Alavi, S. E.; Garza, S. F.; Del Rosario-Vargas, E.; Tiedeman, K.; Monteza-Moreno, C. M.; Barrett, B. J.
10.1101/2022.12.22.521421 — animal behavior and cognition — Posted on 2022-12-22
927 Large-scale unsupervised discovery of excitatory morphological cell types in mouse visual cortex
Weis, M. A.; Papadopoulos, S.; Hansel, L.; Lueddecke, T.; Celii, B.; Fahey, P. G.; Bae, J. A.; Bodor, A. L.; Brittain, D.; Buchanan, J.; Bumbarger, D. J.; Castro, M. A.; Cobos, E.; Collman, F.; da Costa, N. M.; Dorkenwald, S.; Elabbady, L.; Froudarakis, E.; Halageri, A.; Jia, Z.; Jordan, C.; Kapner, D.; Kemnitz, N.; Kinn, S.; Lee, K.; Li, K.; Lu, R.; Macrina, T.; Mahalingam, G.; Mitchell, E.; Mondal, S. S.; Mu, S.; Nehoran, B.; Patel, S.; Pitkow, X.; Popovych, S.; Reid, R. C.; Schneider-Mizell, C. M.; Seung, H. S.; Silversmith, W.; Sinz, F. H.; Takeno, M.; Torres, R.; Turner, N. L.; Wong, W.;
10.1101/2022.12.22.521541 — neuroscience — Posted on 2022-12-22
930 LRRC37B is a species-specific regulator of voltage-gated channels and excitability in human cortical neurons
Libe-Philippot, B.; Lejeune, A.; Wierda, K.; Vlaeminck, I.; Beckers, S.; Gaspariunaite, V.; Bilheu, A.; Nyitrai, H.; Vennekens, K.; Bird, T.; Soto, D.; Davis, M.; Comoletti, D.; Theys, T.; de Wit, J.; Vanderhaeghen, P.
10.1101/2022.12.21.521423 — neuroscience — Posted on 2022-12-22
931 Neural circuitry for maternal oxytocin release induced by infant cries
Valtcheva, S.; Issa, H. A.; Bair-Marshall, C. J.; Martin, K. A.; Jung, K.; Zhang, Y.; Buzsaki, G.; Kwon, H.-B.; Froemke, R. C.
10.1101/2021.03.25.436883 — neuroscience — Posted on 2022-12-22
932 Temporal Preparation Drives Statistical Learning Effects
Salet, J. M.; Kruijne, W.; Rijn, H. v.; Zimmermann, E.; Schlichting, N.
10.1101/2022.08.06.502990 — neuroscience — Posted on 2022-12-22
933 Omada: Robust clustering of transcriptomes through multiple testing
Kariotis, S.; Tan, P. F.; Lu, H.; Rhodes, C. J.; Wilkins, M. R.; Lawrie, A.; Wang, D.
10.1101/2022.12.19.519427 — bioinformatics — Posted on 2022-12-22
934 Megafaunal extinctions--not climate change--seem to explain Holocene genetic diversity declines in Numenius shorebirds
Tan, H. Z.; Jansen, J. J. F. J.; Allport, G. A.; Garg, K. M.; Chattopadhyay, B.; Irestedt, M.; Pang, S. E. H.; Chilton, G.; Gwee, C. Y.; Rheindt, F. E.
10.1101/2021.07.02.450884 — evolutionary biology — Posted on 2022-12-22
935 Cost-effective hybrid long-short read assembly delineates alternative GC-rich Streptomyces chassis for natural product discovery
Heng, E.; Tan, L. L.; Tay, D. W. P.; Lim, Y. H.; Yang, L.-K.; Seow, D. C. S.; Leong, C. Y.; Ng, V.; Ng, S. B.; Kanagasundaram, Y.; Wong, F. T.; Koduru, L.
10.1101/2022.12.05.519232 — genomics — Posted on 2022-12-22
938 Single-Cell Analysis of 5-ALA Intraoperative Labeling Specificity for Glioblastoma
Liu, Z.; Mela, A.; Furnari, J.; Argenziano, M. G.; Kotidis, C.; Sperring, C.; Humala, N.; Bruce, J. N.; Canoll, P.; Sims, P. A.
10.1101/2022.12.17.520870 — cancer biology — Posted on 2022-12-22
939 A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinoma
Patel, A.; Patel, P.; Mandlik, D.; Patel, K.; Malaviya, P.; Johar, K.; Swamy, K. B.; Patel, S.; Tanavde, V.
10.1101/2022.05.31.494114 — cancer biology — Posted on 2022-12-22
940 CRISPR-Detector: Fast and Accurate Detection, Visualization, and Annotation of Genome-Wide Mutations Induced by Gene Editing Events
Huang, L.; Wang, D.; Chen, H.; Hu, J.; Dai, X.; Liu, C.; Li, A.; Shen, X.; Qi, C.; Sun, H.; Zhang, D.; Chen, T.; Jiang, Y.
10.1101/2022.02.16.480781 — bioinformatics — Posted on 2022-12-22
941 Next-generation plasmids for transgenesis in zebrafish and beyond
Kemmler, C. L.; Moran, H. R.; Murray, B. F.; Scoresby, A.; Klem, J. R.; Eckert, R. L.; Lepovsky, E.; Bertho, S.; Nieuwenhuize, S.; Burger, S.; D'Agati, G.; Betz, C.; Puller, A.-C.; Felker, A.; Ditrychova, K.; Boetschi, S.; Affolter, M.; Rohner, N.; Lovely, C. B.; Kwan, K. M.; Burger, A.; Mosimann, C.
10.1101/2022.12.13.520107 — genetics — Posted on 2022-12-22
944 Circadian ribosome profiling reveals a role for the Period2 upstream opening reading frame in sleep
Millius, A.; Yamada, R.; Fujishima, H.; Maeda, K.; Standley, D. M.; Sumiyama, K.; Perrin, D.; Ueda, H. R.
10.1101/2022.08.09.503391 — cell biology — Posted on 2022-12-21
947 Can hubs of the human connectome be identified consistently with diffusion MRI?
Gajwani, M.; Oldham, S. J.; Pang, J. C.; Arnatkeviciute, A.; Tiego, J.; Bellgrove, M. A.; Fornito, A.
10.1101/2022.12.21.521366 — neuroscience — Posted on 2022-12-21
949 Point-of-care peptide hormone production enabled by cell-free protein synthesis
DeWinter, M. A.; Thames, A. H.; Guerrero, L.; Kightlinger, W.; Karim, A. S.; Jewett, M. C.
10.1101/2022.12.03.518932 — synthetic biology — Posted on 2022-12-21
956 Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during a period of rapid postnatal growth
Zanini, F.; Che, X.; Knutsen, C.; Liu, M.; Suresh, N. E.; Domingo-Gonzalez, R.; Dou, S. H.; Pryhuber, G. S.; Jones, R. C.; Quake, S. R.; Cornfield, D. N.; Alvira, C. M.
10.1101/2021.04.27.441649 — developmental biology — Posted on 2022-12-21
957 Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma
De Martino, M.; Daviaud, C.; Minns, H. E.; Attarwala, N.; Chen, Q.; Dephoure, N.; Choi, S.-W.; Rabadan, R.; Gartrell, R. D.; Laiakis, E. C.; Vanpouille-Box, C.
10.1101/2022.06.01.494338 — cell biology — Posted on 2022-12-21
959 LRRC37B is a species-specific regulator of voltage-gated channels and excitability in human cortical neurons
Libe-Philippot, B.; Lejeune, A.; Wierda, K.; Vlaeminck, I.; Beckers, S.; Gaspariunaite, V.; Bilheu, A.; Nyitrai, H.; Vennekens, K.; Bird, T.; Soto, D.; Comoletti, D.; Theys, T.; de Wit, J.; Vanderhaeghen, P.
10.1101/2022.12.21.521423 — neuroscience — Posted on 2022-12-21
962 Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia
Gaspari, S.; Labouebe, G.; Picard, A.; Berney, X. P.; Rodriguez Sanchez-Archidona, A.; Thorens, B.
10.1101/2022.10.21.513159 — physiology — Posted on 2022-12-21
969 MultiGML: Multimodal Graph Machine Learning for Prediction of Adverse Drug Events
Krix, S.; DeLong, L. N.; Madan, S.; Domingo-Fernandez, D.; Ahmad, A.; Gul, S.; Zaliani, A.; Fröhlich, H.
10.1101/2022.12.16.520738 — bioinformatics — Posted on 2022-12-21
970 ChILL & DisCO to discover competitive, connective and allosteric Nanobodies that modulate the SOS1-RAS protein-protein interactions and tune the nucleotide exchange rate
Fischer, B.; Uchanski, T.; Sheryazdanova, A.; Gonzalez, S.; Volkov, A. N.; Brosens, E.; Zogg, T.; Kalichuk, V. V.; Ballet, S.; Versees, W.; Sablina, A. A.; Pardon, E.; Wohlkonig, A.; Steyaert, J.
10.1101/2022.12.06.519258 — bioengineering — Posted on 2022-12-21
971 Lipid droplets control mitogenic lipid mediator production in human cancer cells
Jarc Jovicic, E.; Pucer Janez, A.; O. Eichmann, T.; Koren, S.; Brglez, V.; Jordan, P. M.; Gerstmeier, J.; Lainscek, D.; Golob-Urbanc, A.; Jerala, R.; Lambeau, G.; Werz, O.; Zimmermann, R.; Petan, T.
10.1101/2021.11.25.470010 — biochemistry — Posted on 2022-12-21
973 Long-term balancing selection and the genetic load linked to the self-incompatibility locus in Arabidopsis halleri and A. lyrata.
Le Veve, A.; Burghgraeve, N.; Genete, M.; Lepers-Blassiau, C.; Takou, M.; De Meaux, J.; Mable, B. K.; Durand, E.; Vekemans, X.; Castric, V.
10.1101/2022.04.12.487987 — genomics — Posted on 2022-12-21
975 Factors influencing tissue cyst yield in a murine model of chronic toxoplasmosis
Troublefield, C. A.; Murphy, R. D.; Miracle, J. S.; Donkin, R. W.; Sinai, A. P.
10.1101/2022.12.19.521147 — microbiology — Posted on 2022-12-21
979 Neurexins in serotonergic neurons regulate serotonin transmission and complex mouse behaviors
Cheung, A.; Konno, K.; Imamura Kawasawa, Y.; Matsui, A.; Abe, M.; Sakimura, K.; Sasaoka, T.; Uemura, T.; Watanabe, M.; Futai, K.
10.1101/2021.12.09.471904 — neuroscience — Posted on 2022-12-21
980 Evolutionary-scale prediction of atomic level protein structure with a language model
Lin, Z.; Akin, H.; Rao, R.; Hie, B.; Zhu, Z.; Lu, W.; Smetanin, N.; Verkuil, R.; Kabeli, O.; Shmueli, Y.; dos Santos Costa, A.; Fazel-Zarandi, M.; Sercu, T.; Candido, S.; Rives, A.
10.1101/2022.07.20.500902 — synthetic biology — Posted on 2022-12-21
981 Prophylactic efficacy of riluzole against anxiety- and depressive-like behaviors in two rodent stress models
Bansal, Y.; Fee, C.; Misquitta, K.; Codeluppi, S. A.-M.; Sibille, E.; Berman, R.; Coric, V.; Sanacora, G.; Banasr, M.
10.1101/2020.08.07.242057 — pharmacology and toxicology — Posted on 2022-12-21
982 STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia
Suske, T.; Sorger, H.; Ruge, F.; Prutsch, N.; Zimmerman, M. W.; Eder, T.; Maurer, B.; Wagner, C.; Schoenefeldt, S.; Spirk, K.; Pichler, A.; Pemovska, T.; Schweicker, C.; Poeloeske, D.; Jungherz, D.; Mueller, T. A.; Aung, M. M. K.; Pham, H. T. T.; Zimmel, K.; Krausgruber, T.; Bock, C.; Mueller, M.; Dahlhoff, M.; Boersma, A.; Ruelicke, T.; Fleck, R.; Gunning, P. T.; Aittokallio, T.; Mustjoki, S.; Sanda, T.; Hartmann, S.; Grebien, F.; Hoermann, G.; Haferlach, T.; Staber, P. B.; Neubauer, H. A.; Look, A. T.; Herling, M.; Moriggl, R.
10.1101/2022.12.21.519945 — cancer biology — Posted on 2022-12-21
983 Efficacy and safety of glycosphingolipid SSEA-4 targeting CAR-T cells in an ovarian carcinoma model
Monzo, H.; Hyytiäinen, M.; Elbasani, E.; Kalander, K.; Wall, J.; Moyano-Galceran, L.; Tanjore Ramanathan, J.; Jukonen, J.; Laakkonen, P.; Ristimäki, A.; Carlson, J.; Lehti, K.; Salehi, S.; Puolakkainen, P.; Haglund, C.; Seppänen, H.; Leppa, S.; Ojala, P. M.
10.1101/2022.09.02.506335 — cancer biology — Posted on 2022-12-21
985 Biologically-informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post-treatment glioblastoma
Wang, H.; Argenziano, M. G.; Yoon, H.; Boyett, D.; Save, A.; Petridis, P.; Savage, W.; Jackson, P.; Hawkins-Daarud, A.; Tran, N.; Hu, L.; Al-Dalahmah, O.; Bruce, J. N.; Grinband, J.; Swanson, K. R.; Canoll, P.; Li, J.
10.1101/2022.12.20.521086 — cancer biology — Posted on 2022-12-21
989 Inflammatory Synovial Fibroblast Culture in 3D Systems: A Comparative Transcriptomic and Functional Study.
Khan, A.; Dobre, O.; Wang, Y.; Sartyoungkul, T.; Salmeron-Sanchez, M.; Harnett, M. M.; Pineda, M.
10.1101/2022.12.21.521283 — bioengineering — Posted on 2022-12-21
991 Discovery and molecular basis of chloride as an allosteric activator and catalytic inhibitor for Class-D bata-lactamases.
Zhou, Q.; Bell, H.; Catalan, P. F.; Baumann, P.; Evans, R.; Yang, J.; Zhang, Z.; Zappala, D.; Zhang, Y.; Blackburn, G. M.; He, Y.; Jin, Y.
10.1101/2022.12.20.520813 — biochemistry — Posted on 2022-12-21
995 Epistasis between promoter activity and coding mutations shapes gene evolvability
Caballero, A. F. C.; Gagnon-Arsenault, I.; Dube, A. K.; Despres, P. C.; Kumar, P.; Lafontaine, K.; Pelletier, J. N.; Landry, C. R.
10.1101/2022.06.07.495002 — evolutionary biology — Posted on 2022-12-21
997 Spatiotemporal specification of green and red cones in human retinas and organoids
Hadyniak, S. E.; Eldred, K. C.; Brenerman, B.; Hussey, K. A.; Hagen, J. F. D.; McCoy, R. C.; Sauria, M. E. G.; Kuchenbecker, J. A.; Reh, T. A.; Glass, I.; Neitz, M.; Neitz, J.; Taylor, J.; Johnston, R. J.
10.1101/2021.03.30.437763 — developmental biology — Posted on 2022-12-21
998 Deep learning-enabled design of synthetic orthologs of a signaling protein
Lian, X.; Praljak, N.; Subramanian, S.; Wasinger, S.; Ranganathan, R.; Ferguson, A. L.
10.1101/2022.12.21.521443 — molecular biology — Posted on 2022-12-21
1003 The vacuolar sugar transporter EARLY RESPONSE TO DEHYDRATION 6-LIKE4 regulates fructose signaling and plant growth
Khan, A.; Cheng, J.; Kitashova, A.; Fürtauer, L.; Nägele, T.; Picco, C.; Scholz-Starke, J.; Keller, I.; Neuhaus, H. E.; Pommerrenig, B.
10.1101/2022.12.21.521376 — plant biology — Posted on 2022-12-21
1005 Mitochondrial folate metabolism inhibition drives differentiation through mTORC1 mediated purine sensing
Zarou, M. M.; Rattigan, K. M.; Sarnello, D.; Dawson, A.; Ianniciello, A.; Dunn, K.; Copland, M.; Sumpton, D.; Vazquez, A.; Helgason, V.
10.1101/2022.12.21.521404 — cancer biology — Posted on 2022-12-21
1006 SurvBoard: Standardised Benchmarking for Multi-omics Cancer Survival Models
Wissel, D.; Janakarajan, N.; Grover, A.; Toniato, E.; Martinez, M. R.; Boeva, V.
10.1101/2022.11.18.517043 — bioinformatics — Posted on 2022-12-21
1009 Actomyosin remodeling regulates biomineral formation, growth and morphology during eukaryote skeletogenesis
Hijaze, E.; Gildor, T.; Seidel, R.; Winter, M.; Bertinetti, L.; Layous, M.; Politi, Y.; de-Leon, S. B.-T.
10.1101/2022.12.21.521381 — developmental biology — Posted on 2022-12-21
1011 Molecular anatomy of eosinophil activation by IL5 and IL33
Mitchell, J. M.; Mabin, J. W.; Muehlbauer, L. K.; Annis, D. S.; Mathur, S. K.; Johansson, M. W.; Hebert, A. S.; Fogerty, F. J.; Coon, J. J.; Mosher, D. F.
10.1101/2022.12.21.521419 — cell biology — Posted on 2022-12-21
1013 A Spatiotemporal Notch Interaction Map from Membrane to Nucleus
Martin, A. P.; Bradshaw, G. A.; Eisert, R. J.; Egan, E. D.; Tveriakhina, L.; Rogers, J. M.; Dates, A. N.; Scanavachi, G.; Aster, J. C.; Kirchhausen, T.; Kalocsay, M.; Blacklow, S. C.
10.1101/2022.12.21.521435 — molecular biology — Posted on 2022-12-21
1017 Tobacco smoke exposure results in recruitment of inflammatory airspace monocytes and accelerated growth of Mycobacterium tuberculosis
Corleis, B.; Tzouanas, C. N.; Wadsworth, M. H.; Cho, J. L.; Linder, A. H.; Schiff, A. E.; Dickey, A. K.; Medoff, B. D.; Shalek, A. K.; Kwon, D. S.
10.1101/2022.12.21.521304 — immunology — Posted on 2022-12-21
1018 Immunomodulation of Neutrophil Granulocyte Functions by Bacterial Polyphosphates
Krenzlin, V.; Schoeche, J.; Walachowski, S.; Reinhardt, C.; Radsak, M. P.; Bosmann, M.
10.1101/2022.12.21.521352 — immunology — Posted on 2022-12-21
1019 Oral delivery of GLP-1R agonist by an engineered probiotic yeast strain has anti-obesity effects in mice
Hedin, K. A.; Zhang, H.; Kruse, V.; Rees, V. E.; Bäckhed, F.; Greiner, T. U.; Vazquez-Uribe, R.; Sommer, M. O. A.
10.1101/2022.12.21.521368 — synthetic biology — Posted on 2022-12-21
1020 High-resolution glucose fate-mapping reveals LDHB-dependent lactate production by human pancreatic β cells
Cuozzo, F.; Nasteska, D.; Jiao, Z.; Smith, H. R.; Bonner, C.; Kerr-Conte, J.; Pattou, F.; Nano, R.; Piemonti, L.; Roberts, J.; Lavery, G. G.; Akerman, I.; Tennant, D. A.; Ludwig, C.; Hodson, D. J.
10.1101/2022.12.21.521364 — physiology — Posted on 2022-12-21
1021 O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors
Zhang, Z.; Huang, Z.; Awad, M.; Elsalanty, M.; Cray, J.; Ball, L. E.; Maynard, J.; Burlingame, A. L.; Zeng, H.; Mansky, K. C.; Ruan, H.-B.
10.1101/2022.12.21.521379 — physiology — Posted on 2022-12-21
1023 The Mba1 homologue of Trypanosoma brucei is involved in the biogenesis of oxidative phosphorylation complexes
Wenger, C.; Harsman, A.; Niemann, M.; Oeljeklaus, S.; von Känel, C.; Calderaro, S.; Warscheid, B.; Schneider, A.
10.1101/2022.12.21.521360 — biochemistry — Posted on 2022-12-21
1024 Variability of Phenylalanine side chain conformations facilitates promiscuity of Fatty acid binding in Cockroach milk proteins.
Radhakrishnan Santhakumari, P.; Dhanabalan, K.; Virani, S.; Hopf-Jannasch, A. S.; Benoit, J. B.; Chopra, G.; Subramanian, R.
10.1101/2022.12.21.521413 — biochemistry — Posted on 2022-12-21
1025 Metal-driven anaerobic oxidation of methane as an important methane sink in methanic cold seep sediments
Xiao, X.; Luo, M.; Zhang, C.; Zhang, T.; Yin, X.; Wu, X.; Zhao, J.; Tao, J.; Chen, Z.; Liang, Q.; Liang, Q.; Dong, X.
10.1101/2022.12.21.518016 — microbiology — Posted on 2022-12-21
1032 Nigral pathology contributes to microstructural integrity of striatal and frontal tracts in Parkinson's disease
Lin, C.-P.; Knoop, L. E.; Frigerio, I.; Bol, J. G.; Rozemuller, A. J.; Berendse, H. W.; Pouwels, P. J.; van de Berg, W. D.; Jonkman, L. E.
10.1101/2022.12.21.521411 — neuroscience — Posted on 2022-12-21
1033 Endogenous opioid release following orgasm in man: A combined PET-fMRI study
Jern, P.; Chen, J.; Tuisku, J.; Saanijoki, T.; Hirvonen, J.; Lukkarinen, L.; Manninen, S.; Helin, S.; Putkinen, V.; Nummenmaa, L.
10.1101/2022.12.21.521382 — neuroscience — Posted on 2022-12-21
1035 Socio-demographic determinants of monkeypox virus preventive behavior: a cross-sectional study in Pakistan
Jamil, H.; Idrees, M.; Idrees, K.; Tariq, W.; Sayyeda, Q.; Asghar, M. S.; Tahir, M. J.; Akram, S.; Ullah, K.; Ahmed, A.; Mohanty, A.; Padhi, B. K.; Sah, R.
10.1101/2022.12.20.521248 — microbiology — Posted on 2022-12-21
1037 Mitochondrial phosphagen kinases support the volatile power demands of motor nerve terminals
Justs, K. A.; Sempertegui, S.; Riboul, D. V.; Oliva, C. D.; Durbin, R. J.; Crill, S.; Su, C.; Renden, R. B.; Fily, Y.; Macleod, G. T.
10.1101/2022.12.21.521290 — neuroscience — Posted on 2022-12-21
1040 Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity
Safra, M.; Tamari, Z.; Polak, P.; Shiber, S.; Matan, M.; Karameh, H.; Helviz, Y.; Levy-Barda, A.; Yahalom, V.; Peretz, A.; Ben-Chetrit, E.; Brenner, B.; Tuller, T.; Gal-Tanamy, M.; Yaari, G.
10.1101/2022.12.20.521139 — immunology — Posted on 2022-12-21
1041 Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
Geyer, C. E.; Chen, H.-J.; Bye, A. P.; Manz, X. D.; Guerra, D.; Caniels, T. G.; Bijl, T. P. L.; Griffith, G. R.; Hoepel, W.; de Taeye, S. W.; Veth, J.; Vlaar, A. P. J.; Amsterdam UMC COVID-19 Biobank, ; Vidarsson, G.; Bogaard, H. J.; Aman, J.; Gibbins, J. M.; van Gils, M. J.; Winther, M. P. J.; den Dunnen, J.
10.1101/2022.12.20.521247 — immunology — Posted on 2022-12-21
1044 Exogenous chromosomes reveal how sequence composition drives chromatin assembly, activity, folding and compartmentalization
Chapard, C.; Meneu, L.; Serizay, J.; Routhier, E.; Ruault, M.; Bignaud, A.; Gourgues, G.; Lartigue, C.; Piazza, A.; Taddei, A.; Beckouet, F.; Mozziconacci, J.; Koszul, R.
10.1101/2022.12.21.520625 — genetics — Posted on 2022-12-21
1045 Chronic modulation of human memory and thalamic-hippocampal theta activities.
Marks, V. S.; Lech, M.; Gregg, N. M.; Sladky, V.; Mivalt, F.; Crepeau, D.; Dolezal, J.; Alden, E.; Lundstrom, B.; Klassen, B.; Messina, S.; Brinkmann, B. H.; Miller, K. J.; Van Gompel, J. J.; Kremen, V.; Worrell, G.; Kucewicz, M. T.
10.1101/2022.12.21.521275 — neuroscience — Posted on 2022-12-21
1049 The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo
Doggett, K.; Keating, N.; Dehkhoda, F.; Bidgood, G. M.; Leong, E.; Kueh, A.; Nicola, N. A.; Kershaw, N. J.; Babon, J. J.; Alexander, W. S.; Nicholson, S. E.
10.1101/2022.12.20.521329 — cell biology — Posted on 2022-12-21
1050 Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response
Komatsu, M.; Ikeda, R.; Noshiro, D.; Morishita, H.; Takada, S.; Kageyama, S.; Fujioka, Y.; Funakoshi, T.; Komatsu-Hirota, S.; Arai, R.; Ryzhii, E.; Abe, M.; Koga, T.; Nakao, M.; Sakimura, K.; Horii, A.; Waguri, S.; Ichimura, Y.; Noda, N. N.
10.1101/2022.12.21.521356 — cell biology — Posted on 2022-12-21
1051 Core genome MLST for epidemiological and evolutionary analyses of phytopathogenic Xanthomonas citri
Ragupathy, R.; Jolley, K. A.; Zamuner, C.; Jones, J. B.; Redfern, J.; Behlau, F.; Ferreira, H.; Enright, M. C.
10.1101/2022.12.20.521341 — microbiology — Posted on 2022-12-21
1052 A standardized quantitative analysis strategy for stable isotope probing metagenomics
Vyshenska, D.; Sampara, P.; Singh, K.; Tomatsu, A.; Kauffman, W. B.; Nuccio, E.; Blazewicz, S. J.; Pett-Ridge, J.; Varghese, N.; Kellom, M.; Clum, A.; Riley, R.; Roux, S.; Eloe-Fadrosh, E. A.; Ziels, R. M.; Malmstrom, R. R.
10.1101/2022.12.20.521340 — microbiology — Posted on 2022-12-21
1054 Metabolite diversity among Prochlorococcus strains belonging to divergent ecotypes
Kujawinski, E. B.; Braakman, R.; Longnecker, K.; Chisholm, S. W.; Becker, J. W.; Dooley, K.; Kido Soule, M. C.; Swarr, G. J.; Halloran, K.
10.1101/2022.12.20.521339 — microbiology — Posted on 2022-12-21
1055 Inhibition of pyrimidine synthesis in murine skin wounds induces a pyoderma gangrenosum-like neutrophilic dermatosis accompanied by spontaneous gut inflammation
Jatana, S.; Ponti, A. K.; Johnson, E. E.; Rebert, N. A.; Smith, J. L.; Fulmer, C. G.; Maytin, E. V.; Achkar, J.-P.; Fernandez, A. P.; McDonald, C.
10.1101/2022.12.20.521286 — immunology — Posted on 2022-12-21
1056 Designing epitope-focused vaccines via antigen reorientation
Xu, D.; Li, C.; Utz, A.; Weidenbacher, P. A. B.; Tang, S.; Sanyal, M.; Pulendran, B.; Kim, P. S.
10.1101/2022.12.20.521291 — immunology — Posted on 2022-12-21
1057 Hypothalamic supramammillary neurons that project to the medial septum control wakefulness
Liang, M.; Jian, T.; Jin, W.; Chen, Q.; Yang, X.; Wang, R.; Xiao, J.; Yang, Z.; Liao, X.; Chen, X.; Wang, L.; Qin, H.
10.1101/2022.12.20.521335 — neuroscience — Posted on 2022-12-21
1060 Benchmarking single-cell hashtag oligo demultiplexing methods
Howitt, G.; Feng, Y.; Tobar, L.; Vassiliadis, D.; Hickey, P.; Dawson, M. A.; Ranganathan, S.; Shanthikumar, S.; Neeland, M.; Maksimovic, J.; Oshlack, A.
10.1101/2022.12.20.521313 — bioinformatics — Posted on 2022-12-21
1066 A novel performance scoring quantification framework for stress test set-ups
Kozlovski, T.; Hausdorff, J. M.; Davidov, O.; Giladi, N.; Mirelman, A.; Benjamini, Y.
10.1101/2022.12.21.521346 — bioengineering — Posted on 2022-12-21
1069 Recurrent hypoxia in a rat model of sleep apnea during pregnancy leads to microglia-dependent respiratory deficits and persistent neuroinflammation in adult male offspring
Mickelson, C. R.; Ewald, A. C.; Gumnit, M. G.; Meza, A. L.; Radcliff, A. B.; Johnson, S. M.; Ouellette, J. N.; Kermath, B. A.; Roopra, A.; Cahill, M. E.; Watters, J. J.; Baker-Herman, T.
10.1101/2022.12.20.521336 — neuroscience — Posted on 2022-12-21
1072 Transposable element and host silencing activity in gigantic genomes
Wang, J.; Yuan, L.; Tang, J.; Liu, J.; Sun, C.; Itgen, M. W.; Chen, G.; Sessions, S. K.; Zhang, G.; Mueller, R. L.
10.1101/2022.12.20.521252 — genomics — Posted on 2022-12-21
1077 The FLOWERING LOCUS T LIKE 2-1 gene of Chenopodium triggers precocious flowering in Arabidopsis seedlings
Abeyawardana, O. A. J.; Moravec, T.; Kruger, M.; Belz, C.; Gutierrez-Larruscain, D.; Vondrakova, Z.; Eliasova, K.; Storchova, H.
10.1101/2022.12.20.521231 — plant biology — Posted on 2022-12-21
1081 Bovine blastocyst like structures derived from stem cell cultures
Pinzon-Arteaga, C. A.; Wang, Y.; Wei, Y.; Li, L.; Ribeiro Orsi, A. E.; Scatolin, G.; Liu, L.; Sakurai, M.; Ye, J.; Yu, L.; Li, B.; Jiang, Z.; Wu, J.
10.1101/2022.12.20.521301 — developmental biology — Posted on 2022-12-21
1090 Transcriptomic reprogramming in a susceptible Phaseolus vulgaris L. variety during Pseudomonas syringae attack: The key role of homogalacturonan methylation
De la Rubia, A. G.; Largo-Gosens, A.; Yusta, R.; Sepulveda-Orellana, P.; Riveros, A.; Centeno, M. L.; Sanhueza, D.; Meneses, C.; Saez-Aguayo, S.; Garcia-Angulo, P.
10.1101/2022.12.19.521100 — plant biology — Posted on 2022-12-21
1091 FOXC2 marks and maintains the primitive spermatogonial stem cells subpopulation in the adult testis
Wang, Z.; Jin, C.; Li, P.; Li, Y.; Tang, J.; Yu, Z.; Jiao, T.; Ou, J.; Wang, H.; Zou, D.; Li, M.; Mang, X.; Liu, J.; Lu, Y.; Li, K.; Zhang, N.; Miao, S.; Yu, J.; Wang, L.; Song, W.
10.1101/2022.12.20.521179 — developmental biology — Posted on 2022-12-21
1092 Pharmacological elevation of cellular dihydrosphingomyelin provides a novel antiviral strategy against West Nile virus infection
Jimenez de Oya, N.; San-Felix, A.; Casasampere, M.; Blazquez, A. B.; Mingo-Casas, P.; Escribano-Romero, E.; Calvo-Pinilla, E.; Poderoso, T.; Casas, J.; Saiz, J.-C.; Perez-Perez, M. J.; Martin-Acebes, M. A.
10.1101/2022.12.19.521146 — microbiology — Posted on 2022-12-21
1093 Predicting MmpR-based bedaquiline resistance using sequence- and structure-based features
Riviere, E.; Safarpour, M.; Meysman, P.; Cuypers, B.; Meehan, C.; Laukens, K.; van Rie, A.
10.1101/2022.12.19.521152 — microbiology — Posted on 2022-12-21
1095 QRATER: a collaborative and centralized imaging quality control web-based application.
Fernandez-Lozano, S.; Dadar, M.; Morrison, C.; Manera, A.; Andrews, D.; Rajabli, R.; Madge, V.; St-Onge, E.; Shafiee, N.; Livadas, A.; Fonov, V.; Collins, D. L.; for Alzheimer's Disease Neuroimaging Initiative,
10.1101/2022.12.20.521204 — bioinformatics — Posted on 2022-12-21
1101 Newly repopulated spinal cord microglia exhibit a unique transcriptome and coincide with sex-independent pain resolution
Donovan, L. J.; Bridges, C. M.; Nippert, A. R.; Wang, M.; Wu, S.; Forman, T. E.; Haight, E. S.; Huck, N. A.; Jordan, C. E.; Gardner, A. S.; Nair, R. V.; Tawfik, V. L.
10.1101/2022.12.20.521295 — neuroscience — Posted on 2022-12-21
1102 Exploiting effector - host interactions using TurboID-based proximity labeling
Shi, W.; Stolze, S. C.; Nakagami, H.; Misas Villamil, J. C.; Saur, I. M.; Doehlemann, G.
10.1101/2022.12.19.521009 — plant biology — Posted on 2022-12-21
1107 CRISPR-Detector: Fast and Accurate Detection, Visualization, and Annotation of Genome-Wide Mutations Induced by Gene Editing Events
Huang, L.; Wang, D.; Chen, H.; Hu, J.; Dai, X.; Liu, C.; Li, A.; Shen, X.; Qi, C.; Sun, H.; Zhang, D.; Chen, T.; Jiang, Y.
10.1101/2022.02.16.480781 — bioinformatics — Posted on 2022-12-21
1109 DeepGWAS: Enhance GWAS Signals for Neuropsychiatric Disorders via Deep Neural Network
Wen, J.; Li, G.; Chen, j.; Sun, Q.; Liu, W.; Guan, W.; Lai, B.; Szatkiewicz, J. P.; He, X.; Sullivan, P. F.; Li, Y.
10.1101/2022.12.20.521277 — genetics — Posted on 2022-12-21
1113 Composition can buffer protein dynamics within liquid-like condensates.
Jelenic, S.; Bindics, J.; Czermak, P.; Pillai, B. R.; Ruer, M.; Hoege, C.; Holehouse, A. S.; Saha, S.
10.1101/2022.05.16.492059 — cell biology — Posted on 2022-12-20
1114 Characterisation of key genotypic and phenotypic traits of clinical cystic fibrosis Staphylococcus aureus isolates
Mossop, M.; Robinson, L.; Jiang, J.-H.; Peleg, A. Y.; Blakeway, L. V.; Macesic, N.; Perry, A.; Bourke, S. J.; Ulhuq, F. R.; Palmer, T.
10.1101/2022.12.20.520977 — microbiology — Posted on 2022-12-20
1115 Genetic Substrates of Brain Vulnerability and Resilience in Aging APOE2 Mice
Mahzarnia, A.; Moon, H. S.; Stout, J. A.; Anderson, R. J.; Strain, M.; Tremblay, J. T.; Han, Z. Y.; Niculescu, A. R.; MacFarlane, A.; King, J.; Ashley-Koch, A.; Clark, D. P.; Lutz, M. W.; Badea, A.
10.1101/2022.12.12.520146 — neuroscience — Posted on 2022-12-20
1116 OPTIMIZED NEURON TRACING USING POST HOC REANALYSIS
Azzouz, S.; Walker, L. A.; Doerner, A.; Geisel, K.; Rodriguez-Rivera, A. K.; Li, Y.; Roossien, D. H.; Cai, D.
10.1101/2022.10.10.511642 — neuroscience — Posted on 2022-12-20
1117 Cerebellar Bergmann Glia Integrating Noxious Information Modulate Nocifensive Behaviors
Kim, S. H.; Lee, J.; Roh, S.-E.; Jang, M.; Kim, S.; Lee, J. H.; Seo, J.; Hwang, J. Y.; Lee, Y.-S.; Shigetomi, E.; Lee, C. J. J.; Koizumi, S.; KIM, S. K.; Kim, S. J.
10.1101/2022.05.18.489807 — neuroscience — Posted on 2022-12-20
1119 Multiplex qPCR assays for detection of Anaxyrus californicus and Spea hammondii from environmental DNA
Rodgers, T. W.; Lovich, R. E.; Walton, J. A.; Prince, D. J.; Gonzales, B. R.; Shaffer, H. B.; Mock, K. E.
10.1101/2022.12.20.521282 — zoology — Posted on 2022-12-20
1121 Paralog editing tunes rice stomatal density to maintain photosynthesis and improve drought tolerance
Karavolias, N.; Patel, D.; Seong, K.; Tjahjadi, M.; Gueorguieva, G.-A.; Tanaka, J.; Gallegos Cruz, A.; Lieberman, S.; Litvak, L.; Dahlbeck, D.; Cho, M.-J.; Niyogi, K. K.; Staskawicz, B. J.
10.1101/2021.12.21.473329 — plant biology — Posted on 2022-12-20
1124 A bi-functional PARP-HDAC inhibitor with activity in Ewing sarcoma
Ramos, L.; Truong, S.; Zhai, B.; Joshi, J.; Ghaidi, F.; Lizardo, M. M.; Shyp, T.; Adomat, H.; LeBihan, S.; Collins, C. C.; Bacha, J.; Brown, D.; Langlands, J.; Shen, W.; Lallous, N.; Sorensen, P. H.; Daugaard, M.
10.1101/2022.11.10.515994 — cancer biology — Posted on 2022-12-20
1125 Clinically defined mutations in MEN1 alter its tumor-suppressive function through increased menin turnover
Duan, S.; Sheriff, S.; Elvis-Offiah, U. B.; Sawyer, T. W.; Sundaresan, S.; Cierpicki, T.; Grembecka, J.; Merchant, J. L.
10.1101/2022.12.20.521296 — cancer biology — Posted on 2022-12-20
1128 Reordering of aromatic-rich segments in FUS protein inhibits ageing of FUS-RNA condensates
Blazquez, S.; Sanchez-Burgos, I.; Ramirez, J.; Higginbotham, T.; Conde, M. M.; Collepardo-Guevara, R.; Tejedor, A. R.; Espinosa, J. R.
10.1101/2022.12.14.520383 — biophysics — Posted on 2022-12-20
1129 EPEK: creation and analysis of an Ectopic Pregnancy Expression Knowledgebase
Natarajan, A.; Chivukula, N.; Dhanakoti, G. B.; Sahoo, A. K.; Ravichandran, J.; Samal, A.
10.1101/2022.12.20.521279 — bioinformatics — Posted on 2022-12-20
1131 Microphysiological Drug-Testing Platform For Identifying Responses To Prodrug Treatment In Primary Leukemia
Gokce, F.; Kaestli, A.; Lohasz, C.; de Geus, M.; Kaltenbach, H. M.; Renggli, K.; Bornhauser, B.; Hierlemann, A.; Modena, M. M.
10.1101/2022.04.06.483760 — bioengineering — Posted on 2022-12-20
1134 Cost and benefits of being social: examining the influence of sociality on faecal parasites in free-ranging rhesus macaques
Pavez Fox, M. A.; Escabi-Ruiz, C. M.; Hart, J. D. A.; Negron-Del Valle, J. E.; Phillips, D.; Montague, M. J.; Platt, M.; Ruiz-Lambides, A.; Martinez, M. I.; Cayo Biobank Research Unit, ; Higham, J. P.; Snyder-Mackler, N.; Brent, L. J. N.
10.1101/2022.12.20.521230 — ecology — Posted on 2022-12-20
1135 Validation of ligand tetramers for the detection of antigen-specific lymphocytes
Fitzpatrick, K. S.; Degefu, H. N.; Poljakov, K.; Bibby, M. G.; Remington, A. J.; Gray, M. D.; Boonyaratanakornkit, J.; Rosato, P. C.; Taylor, J. J.
10.1101/2022.10.24.513230 — immunology — Posted on 2022-12-20
1137 Sex and BDNF Val66Met Polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice
Islas, D.; Splinter, T. F.; Ibrahim, M.; Black, N.; Wong, S.; Liu-Ambrose, T.; Barha, C. K.; Galea, L.
10.1101/2022.07.29.502070 — neuroscience — Posted on 2022-12-20
1140 Structure-based learning to model complex protein-DNA interactions and transcription-factor co-operativity in cis-regulatory elements
Fornes, O.; Meseguer, A.; Aguirre-Plans, J.; GOHL, P.; Bota, P. M.; MOLINA-FERNANDEZ, R.; BONET, J.; Hernandez, A. C.; PEGENAUTE, F.; Gallego, O.; Fernandez-Fuentes, N.; Oliva, B.
10.1101/2022.04.17.488557 — bioinformatics — Posted on 2022-12-20
1142 Keratinocyte desmosomal cadherin Desmoglein 1 as a mediator and target of paracrine signaling in the melanoma niche
Burks, H. E.; Pokorny, J. L.; Koetsier, J. L.; Roth-Carter, Q. R.; Arnette, C. R.; Gerami, P.; Seykora, J. T.; Johnson, J. L.; Green, K. J.
10.1101/2022.12.01.518424 — cancer biology — Posted on 2022-12-20
1143 Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis
Roth-Carter, Q. R.; Burks, H. E.; Ren, Z.; Koetsier, J. L.; Tsoi, L. C.; Harms, P. W.; Xing, X.; Kirma, J.; Harmon, R. M.; Godsel, L. M.; Perl, A. L.; Gudjonsson, J. E.; Green, K. J.
10.1101/2022.12.02.518412 — genomics — Posted on 2022-12-20
1147 Control of stereocilia length during development of hair bundles
Krey, J. F.; Chatterjee, P.; Halford, J.; Cunningham, C. L.; Perrin, B. J.; Barr-Gillespie, P. G.
10.1101/2022.12.18.520962 — cell biology — Posted on 2022-12-20
1148 A salt bridge-mediated resistance mechanism to FtsZ inhibitor PC190723 revealed by a cell-based screen
Sharma, A. K.; Poddar, S. M.; Chakraborty, J.; Nayak, B. S.; Kalathil, S.; Mitra, N.; Gayathri, P.; SRINIVASAN, R.
10.1101/2022.04.06.487355 — cell biology — Posted on 2022-12-20
1150 A serine-folate metabolic unit controls resistance and tolerance of infection
Grimes, K.; Beckwith, E. J.; Pearson, W. H.; Jacobson, J.; Chaudhari, S.; Aughey, G. N.; Larrouy-Maumus, G.; Southall, T. D.; Dionne, M. S.
10.1101/2022.11.25.517956 — immunology — Posted on 2022-12-20
1151 Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling
Wilbers, R.; Metodieva, V. D.; Duverdin, S.; Heyer, D. B.; Galakhova, A. A.; Mertens, E. J.; Versluis, T. D.; Baayen, J. C.; Idema, S.; Noske, D. P.; Verburg, N.; Willemse, R. B.; de Witt Hamer, P. C.; Kole, M. H. P.; de Kock, C. P. J.; Mansvelder, H. D.; Goriounova, N. A.
10.1101/2022.11.29.518317 — neuroscience — Posted on 2022-12-20
1152 Conserved cell-type specific signature of resilience to Alzheimer's disease nominates role for excitatory cortical neurons
Telpoukhovskaia, M. A.; Hadad, N.; Gurdon, B.; Dai, Y.; Ouellette, A. R.; Neuner, S. M.; Dunn, A. R.; Willcox, J. A. L.; Wu, Y.; Dumitrescu, L.; Bellur, O.; Zhang, J.-G.; O'Connell, K. M. S.; Dammer, E. B.; Seyfried, N. T.; Muzumdar, S.; Gillis, J.; Robson, P.; Arnold, M.; Hohman, T. J.; Philip, V.; Menon, V.; Kaczorowski, C. C.
10.1101/2022.04.12.487877 — neuroscience — Posted on 2022-12-20
1153 High-throughput functional characterization of combinations of transcriptional activators and repressors
Mukund, A. X.; Tycko, J.; Allen, S. J.; Robinson, S. A.; Andrews, C.; Ludwig, C. H.; Spees, K.; Bassik, M. C.; Bintu, L.
10.1101/2022.12.20.521091 — synthetic biology — Posted on 2022-12-20
1156 A patterned human heart tube organoid model generated by pluripotent stem cell self-assembly
Volmert, B.; Riggs, A.; Wang, F.; Juhong, A.; Kiselev, A.; Kostina, A.; O'Hern, C.; Muniyandi, P.; Wasserman, A.; Huang, A.; Lewis-Israeli, Y.; Park, S.; Qiu, Z.; Zhou, C.; Aguirre, A.
10.1101/2022.12.16.519611 — bioengineering — Posted on 2022-12-20
1157 Chromatin accessibility is a two-tier process regulated by transcription factor pioneering and enhancer activation
Brennan, K. J.; Weilert, M.; Krueger, S.; Pampari, A.; Liu, H.-Y.; Yang, A. W. H.; Hughes, T. R.; Rushlow, C. A.; Kundaje, A.; Zeitlinger, J.
10.1101/2022.12.20.520743 — genomics — Posted on 2022-12-20
1158 A comparison of survey method efficiency for estimating densities of Zebra Mussels (Dreissena polymorpha)
Ferguson, J. M.; Jimenez, L.; Keyes, A. A.; Hilding, A.; McCartney, M. A.; St Clair, K.; Johnson, D. H.; Fieberg, J.
10.1101/2022.12.12.520173 — ecology — Posted on 2022-12-20
1159 Human disturbances erode the diversity of species resilience strategies
Merrien, T.; Davis, K. J.; Capdevila, P.; Di Marco, M.; Salguero-Gomez, R.
10.1101/2021.09.29.462372 — ecology — Posted on 2022-12-20
1161 Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-specific inflammation
O'Brien, V. P.; Kang, Y.; Shenoy, M. K.; Finak, G.; Young, W. C.; Dubrulle, J.; Koch, L.; Martinez, A. E. R.; Snow, J. A.; Williams, J.; Donato, E.; Batra, S. K.; Yeung, C. C.; Bullman, S.; Koch, M. A.; Gottardo, R.; Salama, N. R.
10.1101/2022.12.20.521287 — microbiology — Posted on 2022-12-20
1162 T cell development is regulated by high fidelity replication of mitochondrial DNA
Limper, C.; Bondah, N. B.; Zhu, D.; Villanueva, A. N.; Chukwukere, U. K.; Huang, W.; August, A.
10.1101/2022.12.20.521061 — immunology — Posted on 2022-12-20
1163 Bioactive constituents of Verbena officinalis alleviate inflammation and enhance killing efficiency of natural killer cells
Dai, X.; Zhou, X.; Shao, R.; Zhao, R.; Yanamandra, A. K.; Xing, Z.; Zhang, H.; Wang, Y.; Qu, B.; Wang, Y.
10.1101/2021.10.22.465498 — immunology — Posted on 2022-12-20
1164 Walking bumblebees see faster
Rother, L.; Müller, R.; Kirschenmann, E.; Kaya-Zeeb, S.; Thamm, M.; Pfeiffer, K.
10.1101/2022.12.20.521190 — neuroscience — Posted on 2022-12-20
1172 An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics
Borhani, S. G.; Levine, M. Z.; Krumpe, L. H.; Wilson, J.; Hendrich, C.; O'Keefe, B.; Lo, D.; Sittampalam, G.; Godfrey, A.; Lunsford, R. D.; Mangalampalli, V.; Tao, D.; LeClair, C. A.; Thole, A.; Frey, D.; Swartz, J. R.; Rao, G.
10.1101/2022.12.19.521044 — bioengineering — Posted on 2022-12-20
1177 An oral vaccine for SARS-CoV-2 RBD mRNA-bovine milk-derived exosomes induces a neutralizing antibody response in vivo
Zhang, Q.; Wang, M.; Han, C.; Wen, Z.; Meng, X.; Qi, D.; Wang, N.; Du, H.; Wang, J.; Lu, L.; Ge, X.
10.1101/2022.12.19.517879 — immunology — Posted on 2022-12-20
1178 Rapid recall and de novo T cell responses during SARS-CoV-2 breakthrough infection
Koutsakos, M.; Reynaldi, A.; Lee, W. S.; Nguyen, J.; Amarasena, T.; Taiaroa, G.; Kinsella, P.; Liew, K. C.; Tran, T.; Kent, H. E.; Tan, H.-X.; Rowntree, L. C.; Nguyen, T. H. O.; Thomas, P.; Kedzierska, K.; Petersen, J.; Rossjohn, J.; Williamson, D. A.; Khoury, D.; Davenport, M. P.; Kent, S. J. P.; Wheatley, A. K.; Juno, J. A.
10.1101/2022.12.19.521129 — immunology — Posted on 2022-12-20
1179 LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis
Ogbechi, J.; Wright, H. L.; Balint, S.; Topping, L.; Zec, K.; Huang, I.-S.; Pantazi, E.; Swart, M.; Windell, D.; Marin, E.; Wempe, M. F.; Endou, H.; Thomas, A. M.; Filer, A.; Stone, T. W.; Clarke, A.; Dustin, M.; Williams, R.
10.1101/2022.12.20.520910 — immunology — Posted on 2022-12-20
1182 Post-secretory synthesis of a natural analog of iron-gall ink in the black nectar of Melianthus spp.
Magner, E. T.; Roy, R.; Saxhaug, K. F.; Zambre, A.; Bruns, K.; Snell-Rood, E. C.; Hampton, M.; Hegeman, A. D.; Carter, C.
10.1101/2022.12.20.521234 — plant biology — Posted on 2022-12-20
1183 Acidovorax temperans polarizes T17 cells and skews neutrophil maturation to promote lung adenocarcinoma development
Stone, J. K.; von Muhlinen, N.; Zhang, C.; Robles, A. I.; Vega-Valle, E.; Miyanaga, A.; Matsumoto, M.; Greathouse, K. L.; Cooks, T.; Trinchieri, G.; Harris, C. C.
10.1101/2022.12.20.521215 — cancer biology — Posted on 2022-12-20
1184 Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through unbiased machine learning
Huang, C.; Zhao, Z.; Zhu, F.; Qian, Y.; Lin, D.; Zheng, J.; Chen, H.; Wang, N.; Li, W.; Kong, X.; Huang, Q.; Qin, J.; Du, B.
10.1101/2022.12.20.521217 — cancer biology — Posted on 2022-12-20
1185 Transcriptional Profiles Analysis of COVID-19 and Malaria Patients Reveals Potential Biomarkers in Children
Lambert, N.; Jonas, K.-O. A.; Rissy, W. M.; Diane, U.; Murithi, K.; Peter, K.; Awe, O. I.; Dillman, A.
10.1101/2022.06.30.498338 — bioinformatics — Posted on 2022-12-20
1188 Discovery and molecular basis of chloride as an allosteric activator and catalytic inhibitor for Class-D lactamases.
Zhou, Q.; Bell, H.; Catalan, P. F.; Baumann, P.; Evans, R.; Yang, J.; Zhang, Z.; Zappala, D.; Zhang, Y.; Blackburn, G. M.; He, Y.; Jin, Y.
10.1101/2022.12.20.520813 — biochemistry — Posted on 2022-12-20
1189 Nanopore sequencing for real-time genomic surveillance of Plasmodium falciparum
Girgis, S. T.; Adika, E.; Nenyewodey, F. E.; Senoo Jnr, D. K.; Ngoi, J. M.; Bandoh, K.; Lorenz, O.; van de Steeg, G.; Nsoh, S.; Judge, K.; Pearson, R. D.; Almagro-Garcia, J.; Saiid, S.; Atampah, S.; Amoako, E. K.; Morang'a, C. M.; Asoala, V.; Adjei, E. S.; Burden, W.; Roberts-Sengier, W.; Drury, E.; Goncalves, S.; Awandare, G. A.; Kwiatkowski, D. P.; Amenga-Etego, L. N.; Hamilton, W. L.
10.1101/2022.12.20.521122 — genomics — Posted on 2022-12-20
1191 Genome-based comparison between the recombinant SARS-CoV-2 XBB and its parental lineages
Scarpa, F.; Sanna, D.; Azzena, I.; Casu, M.; Cossu, P.; Fiori, P. L.; Benvenuto, D.; Imperia, E.; Giovanetti, M.; Ceccarelli, G.; Cauda, R.; Cassone, A.; Pascarella, S.; Ciccozzi, M.
10.1101/2022.12.20.521197 — genetics — Posted on 2022-12-20
1196 HIGHLY PHAGOCYTIC LIPID-ASSOCIATED MACROPHAGES (LAMs) ARE INCREASED IN COLONIC LAMINA PROPRIA IN OBESITY
Castoldi, A.; Sanin, D. E.; Bakker, N. v. T.; Aguiar, C. F.; Monteiro, L. d. B.; Rana, N.; Grzes, K. M.; Kabat, A. M.; Curtis, J.; Cameron, A. M.; Caputa, G.; de Souza, T. A.; Souto, F. O.; Buescher, J. M.; Hicks, J. E.; Pearce, E. L.; Pearce, E. J.; Camara, N. O. S.
10.1101/2022.12.20.521239 — immunology — Posted on 2022-12-20
1198 Glycogen-fuelled metabolism supports rapid Mucosal Associated Invariant T cell responses
Cassidy, F. C.; Kedia-Mehta, N.; Bergin, R.; Woodcock, A.; Berisha, A.; Bradley, B. M.; Booth, E.; Ryan, O. K.; Sinclair, L. V.; O'Shea, D.; Hogan, A. E.
10.1101/2022.12.20.521164 — immunology — Posted on 2022-12-20
1199 Contribution of Notch/Wnt signaling modulation in reactive astrocyte reparative response after brain injury
Delgado-Garcia, L. M.; Benincasa, J. C.; Courbassier, N. R.; Ribeiro, T. N.; Porcionatto, M. A.
10.1101/2022.12.20.521209 — neuroscience — Posted on 2022-12-20
1203 Neural, physiological and behavioral correlates of empathy for pain in Tourette syndrome
Weiblen, R.; Robert, C.; Petereit, P.; Heldmann, M.; Munte, T. F.; Munchau, A.; Muller-Vahl, K.; Kramer, U. M.
10.1101/2022.12.19.521056 — neuroscience — Posted on 2022-12-20
1206 Photovoltaic enzymes by design and evolution
Bunzel, H. A.; Smith, J. A.; Oliver, T. A. A.; Jones, M. R.; Mulholland, A. J.; Anderson, R.
10.1101/2022.12.20.521207 — synthetic biology — Posted on 2022-12-20
1208 Phytocytokine signaling integrates cell surface immunity and nitrogen limitation
Rzemieniewski, J.; Leicher, H.; Lee, H. K.; Broyart, C.; Nayem, S.; Wiese, C.; Maroschek, J.; Camgoez, Z.; Olsson Lalun, V.; Djordjevic, M. A.; Vlot, A. C.; Hueckelhoven, R.; Santiago, J.; Stegmann, M.
10.1101/2022.12.20.521212 — plant biology — Posted on 2022-12-20
1210 Acquired and intrinsic resistance to vemurafenib in BRAFV600E-driven melanoma brain metastases
Zhang, P.; Kuil, L. E.; Buil, L. C. M.; Freriks, S.; Beijnen, J. H.; van Tellingen, O.; de Gooijer, M. C.
10.1101/2022.12.20.521202 — pharmacology and toxicology — Posted on 2022-12-20
1211 The paralogues MAGOH and MAGOHB are oncogenic factors in high-grade gliomas and safeguard the splicing of cell division and cell cycle genes
Barreiro, R. A. S.; Guardia, G. D. A.; Meliso, F. M.; Lei, X.; Savio, A.; Fellermeyer, M.; Conceicao, H. B.; Mercuri, R. L. V.; Landry, T.; Qiao, M.; Blazquez, L.; Ule, J.; Penalva, L. O.; Galante, P. A. F.
10.1101/2022.12.20.521107 — cancer biology — Posted on 2022-12-20
1213 Likelihood-based docking of models into cryo-EM maps
Millan, C.; McCoy, A. J.; Terwilliger, T. C.; Read, R. J.
10.1101/2022.12.20.521188 — biophysics — Posted on 2022-12-20
1218 Structural basis of odorant recognition by a human odorant receptor
Billesboelle, C. B.; de March, C. A.; van der Velden, W. J. C.; Ma, N.; Tewari, J.; Linas del Torrent, C.; Li, L.; Faust, B.; Vaidehi, N.; Matsunami, H.; Manglik, A.
10.1101/2022.12.20.520951 — biochemistry — Posted on 2022-12-20
1219 Integrative modeling of guanylate binding protein dimers
Schumann, W.; Loschwitz, J.; Reiners, J.; Degrandi, D.; Pfeffer, K.; Stuehler, K.; Poschmann, G.; Smits, S.; Strodel, B.
10.1101/2022.12.20.521180 — biochemistry — Posted on 2022-12-20
1220 Nucleosome repositioning in chronic lymphocytic leukaemia
Piroeva, K. V.; McDonald, C.; Xanthopoulos, C.; Fox, C.; Clarkson, C. T.; Mallm, J.-P.; Vainshtein, Y.; Ruje, L.; Klett, L. C.; Stilgenbauer, S.; Mertens, D.; Kostareli, E.; Rippe, K.; Teif, V. B.
10.1101/2022.12.20.518743 — genomics — Posted on 2022-12-20
1221 Proximity-dependent recruitment of Polycomb Repressive Complexes by the lncRNA Airn
Braceros, A. K.; Schertzer, M. D.; Omer, A.; Trotman, J. B.; Davis, E. S.; Dowen, J. M.; Phanstiel, D. H.; Lieberman Aiden, E.; Calabrese, M.
10.1101/2022.12.20.521198 — genomics — Posted on 2022-12-20
1222 Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study
Tissink, E.; Shadrin, A. A.; van der Meer, D.; Parker, N.; Hindley, G.; Roelfs, D.; Frei, O.; Fan, C. C.; Nagel, M.; Naerland, T.; Budisteanu, M.; Djurovic, S.; Westlye, L. T.; van den Heuvel, M.; Posthuma, D.; Kaufmann, T.; Dale, A. M.; Andreassen, O.
10.1101/2022.12.20.521181 — genetics — Posted on 2022-12-20
1224 Temperature and depth dependence of the spatial distribution of snow crab
Choi, J. S.; Cameron, B.; Christie, K.; Glass, A.; MacEachern, E.
10.1101/2022.12.20.520893 — ecology — Posted on 2022-12-20
1225 Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Schneider, S.; Kovacevic, A.; Mayer, M.; Dicke, A.-K.; Arevalo, L.; Koser, S. A.; Hansen, J. N.; Young, S.; Brenker, C.; Kliesch, S.; Wachten, D.; Kirfel, G.; Struenker, T.; Tuettelmann, F.; Schorle, H.
10.1101/2022.12.20.521208 — developmental biology — Posted on 2022-12-20
1226 Anatomy of the complete mouse eye vasculature indevelopment and pathology explored by light-sheet fluorescence microscopy
Krimpenfort, L. T.; Garcia-Collado, M.; van Leeuwen, T.; Locri, F.; Luik, A.-L.; Queiro-Palou, A.; Kanatani, S.; Andre, H.; Uhlen, P.; Jakobsson, L.
10.1101/2022.12.20.521194 — developmental biology — Posted on 2022-12-20
1227 Coronary vessel assembly involves patterned endocardial sprouting and tip-cell-to artery specification
Cano, E.; Paech, J.; Kanda, M.; Lindberg, E. L.; Hollfinger, I.; Braeuning, C.; Fischer, C.; Hubner, N.; Gerhardt, H.
10.1101/2022.12.20.517740 — developmental biology — Posted on 2022-12-20
1229 SAFB associates with nascent RNAs to promote gene expression in mouse embryonic stem cells
Cherney, R. E.; Eberhard, Q. E.; Mills, C. A.; Porrello, A.; Zhang, Z.; White, D.; Herring, L. E.; Calabrese, M.
10.1101/2022.12.20.521195 — molecular biology — Posted on 2022-12-20
1230 HIV-1 infection causes depletion of monocytic cells through a non-canonical cell death pathway
Stuck, M.; Arnow, N. D.; Kazmierski, J.; Walper, F.; Goffinet, C.; Bannert, N.; Cingoz, O.
10.1101/2022.12.20.521186 — microbiology — Posted on 2022-12-20
1231 Meningioma microstructure assessed by diffusion MRI: an investigation of the source of mean diffusivity and fractional anisotropy by quantitative histology
Brabec, J.; Friedjungova, M.; Vasata, D.; Englund, E.; Bengzon, J.; Knutsson, L.; Szczepankiewicz, F.; Sundgren, P. C.; Nilsson, M.
10.1101/2022.12.20.521068 — neuroscience — Posted on 2022-12-20
1232 Differential transpiration between pods and leaves during stress combination in soybean
Sinha, R.; Shostak, B.; Preethi Induri, S.; Sen, S.; Zandalinas, S. I.; Joshi, T.; Fritschi, F. B.; Mittler, R.
10.1101/2022.12.20.521196 — plant biology — Posted on 2022-12-20
1233 Status and future perspectives for pikeperch (Sander lucioperca) stocks in Europe
Jakubaviciute, E.; Arula, T.; Dainys, J.; Deweber, J. T.; Gorfine, H.; Harkonen, L. S.; Hyvarinen, P.; Hommik, K.; Kubecka, J.; Lozys, L.; Mustamaki, N.; Naddafi, R.; Olin, M.; Putys, Z.; Sepp, E.; Souza, A. T.; Siaulys, A.; Vaino, V.; Audzijonyte, A.
10.1101/2022.12.20.521162 — ecology — Posted on 2022-12-20
1235 Myc controls IL-15-driven expansion and translational machinery of NK cells
Khameneh, H. J.; Fonta, N.; Zenobi, A.; Niogret, C.; Ventura, P.; Guerra, C.; Kwee, I.; Rinaldi, A.; Pecoraro, M.; Geiger, R.; Cavalli, A.; Bertoni, F.; Vivier, E. E.; Trumpp, A.; Guarda, G.
10.1101/2022.12.20.521160 — immunology — Posted on 2022-12-20
1236 pGG-PIP: A GreenGate (GG) entry vector collection with Plant Immune system Promoters (PIP)
Calabria, J.; Rast-Somssich, M. I.; Wang, L.; Chen, H.-W.; Watt, M.; Idnurm, A.; Persson, S.; Somssich, M.
10.1101/2022.12.20.521163 — plant biology — Posted on 2022-12-20
1237 Biologically-informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post-treatment glioblastoma
Wang, H.; Argenziano, M. G.; Yoon, H.; Boyett, D.; Save, A.; Petridis, P.; Savage, W.; Jackson, P.; Hawkins-Daarud, A.; Tran, N.; Hu, L.; Al-Dalahmah, O.; Bruce, J. N.; Grinband, J.; Swanson, K.; Canoll, P.; Li, J.
10.1101/2022.12.20.521086 — cancer biology — Posted on 2022-12-20
1239 Distributing Aminophospholipids Asymmetrically Across Leaflets Causes Anomalous Membrane Stiffening
Frewein, M. P.; Piller, P.; Semeraro, E. F.; Czakkel, O.; Gerelli, Y.; Porcar, L.; Pabst, G.
10.1101/2022.12.20.521165 — biophysics — Posted on 2022-12-20
1240 CircPrime: a web-based platform for design of specific circular RNA primers
Sharko, F.; Rbbani, G.; Siriyappagouder, P.; Raeymaekers, J. A. M.; Galindo-Villegas, J.; Nedoluzhko, A.; Fernandes, J. M. O.
10.1101/2022.12.20.521155 — bioinformatics — Posted on 2022-12-20
1241 Genetic load and adaptive potential of a recovered avian species that narrowly avoided extinction
Femerling, G.; Van Oosterhout, C.; Feng, S.; Bristol, R.; Zhang, G.; Groombridge, J.; Gilbert, M. T. P.; Morales, H. E.
10.1101/2022.12.20.521169 — evolutionary biology — Posted on 2022-12-20
1242 Symmetry-breaking in adherent pluripotent stem cell-derived developmental patterns
Aguilar-Hidalgo, D.; Ostblom, J.; Siu, M. M.; McMaster, B.; Heydari, T.; Werschler, N.; Tewary, M.; Zandstra, P.
10.1101/2022.12.20.521167 — developmental biology — Posted on 2022-12-20
1243 Factors influencing tissue cyst yield in a murine model of chronic toxoplasmosis
Troublefield, C. A.; Murphy, R. D.; Miracle, J. S.; Donkin, R. W.; Sinai, A. P.
10.1101/2022.12.19.521147 — microbiology — Posted on 2022-12-20
1244 Iron regulatory pathways differentially expressed during Madurella mycetomatis grain development in Galleria mellonella
Abugessaisa, I.; Konings, M.; Manabe, R.-I.; Kawashima, T.; Hasegawa, A.; Takahashi, C.; Tagami, M.; Okazaki, Y.; Lim, W.; Verbon, A.; Fahal, A. H.; Kasukawa, T.; Van de Sande, W.
10.1101/2022.12.20.520897 — microbiology — Posted on 2022-12-20
1253 Analyzing postprandial metabolomics data using multiway models: A simulation study
Li, L.; Yan, S.; Bakker, B. M.; Hoefsloot, H.; Chawes, B.; Horner, D.; Rasmussen, M. A.; Smilde, A. K.; Acar, E.
10.1101/2022.12.19.521154 — systems biology — Posted on 2022-12-20
1256 Molecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3
Gao, Y.; Xu, S.; Cui, X.; Xu, H.; Qiu, Y.; Wei, Y.; Dong, Y.; Zhu, B.; Peng, C.; Liu, S.; Zhang, X. C.; Sun, J.; Huang, Z.; Zhao, Y.
10.1101/2022.12.19.521133 — biophysics — Posted on 2022-12-20
1261 Greengenes2 enables a shared data universe for microbiome studies
McDonald, D.; Jiang, Y.; Balaban, M.; Cantrell, K.; Zhu, Q.; Gonzalez, A.; Morton, J. T.; Nicolaou, G.; Parks, D.; Karst, S. M.; Albertsen, M.; Hugenholtz, P.; DeSantis, T.; Mirarab, S.; Knight, R.
10.1101/2022.12.19.520774 — bioinformatics — Posted on 2022-12-20
1262 Deep learning-based predictive identification of functional subpopulations of hematopoietic stem cells and multipotent progenitors
Wang, S.; Han, J.; Huang, J.; Shi, Y.; Zhou, Y.; Kim, D.; Islam, M. K.; Zhou, J.; Ostrovsky, O.; Lian, Z.; Liu, Y.; Huang, J.
10.1101/2022.12.19.519644 — bioengineering — Posted on 2022-12-20
1264 Molecular engineering of emicizumab to improve hemophilia A treatment
Teranishi-Ikawa, Y.; Soeda, T.; Koga, H.; Yamaguchi, K.; Kato, K.; Esaki, K.; Asanuma, K.; Funaki, M.; Ichiki, M.; Ikuta, Y.; Ito, S.; Joyashiki, E.; Komatsu, S.-I.; Muto, A.; Nishimura, K.; Okuda, M.; Sanada, H.; Sato, M.; Shibahara, N.; Wakabayashi, T.; Yamaguchi, K.; Matsusaki, A.; Sampei, Z.; Shiraiwa, H.; Konishi, H.; Kawabe, Y.; Hattori, K.; Kitazawa, T.; Igawa, T.
10.1101/2022.12.19.520692 — bioengineering — Posted on 2022-12-20
1266 Genomic mate-allocation strategies exploiting additive and non-additive genetic effects to maximise total clonal performance in sugarcane
Yadav, S.; Ross, E. M.; Wei, X.; Powell, O. M.; Hivert, V.; Hickey, L.; Atkin, F.; Deomano, E.; Aitken, K.; Voss-fels, K. P.; Hayes, B. J.
10.1101/2022.12.19.521119 — genomics — Posted on 2022-12-20
1270 Is there an accurate and generalisable way to use soundscapes to monitor biodiversity?
Sethi, S. S.; Bick, A.; Ewers, R. M.; Klinck, H.; Ramesh, V.; Tuanmu, M.-N.; Coomes, D. A.
10.1101/2022.12.19.521085 — ecology — Posted on 2022-12-20
1273 Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures
Kastlmeier, M. T.; Gonzalez Rodriguez, E.; Cabanis, P.; Guenther, E. M.; Koenig, A.-C.; Han, L.; Hauck, S.; Stoeger, T.; Hilgendorff, A.; Voss, C.
10.1101/2022.12.20.521114 — cell biology — Posted on 2022-12-20
1275 Genomic diversity of Streptococcus uberis isolated from clinical mastitis of cattle in selected areas of Bangladesh
Hassan, J.; Bag, M. A. S.; Kabir, A.; Ali, M. W.; Hossain, M.; Rahman, M. T.; Islam, M. S.; Khan, M. S. R.
10.1101/2022.12.19.521080 — microbiology — Posted on 2022-12-20
1276 A superoxide reductase contributes to Clostridioides difficile resistance to oxygen
Kochanowsky, R.; Carothers, K. E.; Roxas, B.; Anwar, F.; Viswanathan, V.; Vedantam, G.
10.1101/2022.12.19.521142 — microbiology — Posted on 2022-12-20
1277 Anti-Biofilm Potential of Nanonized Eugenol against Pseudomonas aeruginosa
Basu, T.; Ghosh, S.; Sett, U.; Pal, A.; Nandy, S.; Nandi, S.; Chakrabarty, S.; Das, A.; Bandyopadhyay, P.
10.1101/2022.12.19.521144 — microbiology — Posted on 2022-12-20
1280 Profiling intra- and inter-individual differences in child and adolescent brain development
Bottenhorn, K. L.; Cardenas-Iniguez, C.; Mills, K. L.; Laird, A. R.; Herting, M. M.
10.1101/2022.12.19.521089 — neuroscience — Posted on 2022-12-20
1281 Comparable neural pathways link psychological stress and brain health in health and multiple sclerosis
Schulz, M.-A.; Hetzer, S.; Eitel, F.; Asseyer, S.; Meyer-Arndt, L.; Schmitz-Hübsch, T.; Bellmann-Strobl, J.; Cole, J. H.; Gold, S. M.; Paul, F.; Ritter, K.; Weygandt, M.
10.1101/2022.12.19.521098 — neuroscience — Posted on 2022-12-20
1285 Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury
Renz, P. V.; Surbek, D.; Haesler, V.; Tscherrig, V.; Huang, E. J.; Chavali, M.; Liddelow, S. A.; Rowitch, D.; Schoeberlein, A.; Brosius Lutz, A. R.
10.1101/2022.12.19.521083 — neuroscience — Posted on 2022-12-20
1286 Maternal microbes and early brain development in mouse
Yeo, X. Y.; Chae, W. R.; Lee, H. U.; Bae, H.-G.; Pettersson, S.; Grandjean, J.; Han, W.; Jung, S.
10.1101/2022.12.19.521137 — neuroscience — Posted on 2022-12-20
1287 MTL neurons phase-lock to human hippocampal theta
Schonhaut, D. R.; Ramayya, A. G.; Solomon, E. A.; Herweg, N. A.; Fried, I.; Kahana, M. J.
10.1101/2022.12.19.521101 — neuroscience — Posted on 2022-12-20
1288 RBAtools: a programming interface for Resource Balance Analysis modelling
Bodeit, O.; Ben Samir, I.; Karr, J. R.; Goelzer, A.; Liebermeister, W.
10.1101/2022.12.19.521060 — systems biology — Posted on 2022-12-20
1295 Multi-location trials and population-based genotyping reveal high diversity and adaptation to breeding environments in a large collection of red clover
Nay, M. M.; Grieder, C.; Frey, L. A.; Amdahl, H.; Radovic, J.; Jaluvka, L.; Palme, A.; Skot, L.; Ruttink, T.; Kolliker, R.
10.1101/2022.12.19.520744 — genetics — Posted on 2022-12-20
1296 Probing the evolutionary dynamics of whole-body regeneration within planarian flatworms
Vila-Farre, M.; Rozanski, A.; Ivankovic, M.; Cleland, J.; Brand, J. N.; Thalen, F.; Grohme, M.; von Kannen, S.; Grosbusch, A.; Vu, H. T.-K.; Prieto, C. E.; Carbayo, F.; Egger, B.; Bleidorn, C.; Rasko, J. E. J.; Rink, J. C.
10.1101/2022.12.19.520916 — evolutionary biology — Posted on 2022-12-20
1298 A Systematic Review and Meta-analysis on the Transcriptomic Signatures in Alcohol Use Disorder- a Translational Approach
Friske, M. M.; Torrico, E. C.; Borruto, A. M.; Haas, M. J. W.; Giannone, F.; Hade, A.-C.; Philips, M.-A.; Sommer, W. H.; Spanagel, R.
10.1101/2022.12.19.521027 — neuroscience — Posted on 2022-12-20
1299 Hybrid-DIA: Intelligent Data Acquisition for Simultaneous Targeted and Discovery Phosphoproteomics in Single Spheroids
Martinez del Val, A.; Fort, K.; Koenig, C.; van der Hoeven, L. R.; Franciosa, G.; Moehring, T.; Ishihama, Y.; Chen, Y.-J.; Makarov, A. A.; Xuan, Y.; Olsen, J. V.
10.1101/2022.12.19.520999 — systems biology — Posted on 2022-12-20
1300 Exploiting effector - host interactions using TurboID-based proximity labeling
Shi, W.; Stolze, S. C.; Nakagami, H.; Misas Villamil, J. C.; Doehlemann, G.
10.1101/2022.12.19.521009 — plant biology — Posted on 2022-12-20
1301 Combining modelling and experimental approaches to assess the feasibility of developing rice-oil palm agroforestry system
Perez, R. P. A.; VEZY, R.; Bordon, R.; Laisne, T.; Roques, S.; Rebolledo, M.-C.; Rouan, L.; Fabre, D.; Gibert, O.; de Raissac, M.
10.1101/2022.12.19.521043 — plant biology — Posted on 2022-12-20
1302 Follicular fluid metabolomic analysis in women with Hashimoto's thyroiditis
da Silva Bastos, D. C.; Costa da Silva, R. E.; Chiamolera, M. I.; Borges de Souza, M. d. C.; de Azevedo Antunes, R.; Marinho de Souza, M.; Allemand Mancebo, A. C.; Fernandes Areas, P. C.; Reis, F. M.; Guimaraes Lo Turco, E.; Bloise, F. F.; Ortiga-Carvalho, T. M.
10.1101/2022.12.19.520992 — physiology — Posted on 2022-12-20
1307 Robust clustering of transcriptomes through multiple testing
Kariotis, S.; Tan, P. F.; Lu, H.; Rhodes, C. J.; Wilkins, M. R.; Lawrie, A.; Wang, D.
10.1101/2022.12.19.519427 — bioinformatics — Posted on 2022-12-20
1309 How Myopia and Glaucoma Influence the Biomechanical Susceptibility of the Optic Nerve Head
Chuangsuwanich, T.; Tun, T.; Braeu, F.; Yeoh, C.; Chong, R.; Wang, X.; Aung, T.; Hoang, Q.; Girard, M. J. A.
10.1101/2022.12.19.520997 — bioengineering — Posted on 2022-12-20
1311 Spatial, temporal and taxonomic patterns of insect extinction in Germany
Hallmann, C.; Hoerren, T. P. B.; Ssymank, A.; Sumser, H. W.; Schwan, H.; Stenmans, W.; Vischer-Leopold, M.; Schaeffler, L.; Sorg, M.
10.1101/2022.12.19.521006 — ecology — Posted on 2022-12-20
1314 Microbial diversity ensures the stability of carbon cycling processes under increasing temperature in model soils
Rohner, N.; Lepori, S.; Loaiza, V.; Sebag, D.; Verrechia, E.; Nelson, D. B.; Kahmen, A.; Niklaus, P. A.-; Laine, A.-L.; Domeignoz-Horta, L. A.
10.1101/2022.12.19.521036 — microbiology — Posted on 2022-12-20
1315 Longitudinal flux balance analyses of a patient with Crohn's disease highlight microbiome metabolic alterations
Basile, A.; Heinken, A.; Hertel, J.; Smarr, L.; Li, W.; Treu, L.; Valle, G.; Campanero, S.; Thiele, I.
10.1101/2022.12.19.520975 — systems biology — Posted on 2022-12-20
1317 Loss of species richness with land use intensity is explained by a reduction in niche differences.
Godoy, O.; Granjel, R.; Van der Plas, F.; Soliveres, S.; Penone, C.; Saiz, H.; Holzel, N.; Prati, D.; Fischer, M.; Allan, E.
10.1101/2022.12.15.520291 — ecology — Posted on 2022-12-20
1318 Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic manner
Ju, A.; Altas, B.; Rhee, H. J.; Schwark, M.; Hassouna, I.; Kawabe, H.; Chowdhury, K.; Ehrenreich, H.; Brose, N.; Rhee, J. S.; Sigler, A.
10.1101/2022.12.19.521004 — neuroscience — Posted on 2022-12-20
1320 Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis
Herold, M.; Potts, M. A.; Mizutani, S.; Garnham, A.; Li-Wai-Suen, C. S. N.; Kueh, A. J.; Tai, L.; Pal, M.; Strasser, A.
10.1101/2022.12.19.520971 — cancer biology — Posted on 2022-12-20
1321 Engineering of the Endogenous HBD promoter increases HbA2
Boontanrart, M. Y.; Mächler, E.; Ponta, S.; Nelis, J. C.; Preiano, V. G.; Corn, J. E.
10.1101/2022.12.19.521003 — genetics — Posted on 2022-12-20
1322 The arms race in noncoding regions of transposable element: the evolution of anti-silencing and RNAi
Sasaki, T.; Kato, K.; Hosaka, A.; Fu, Y.; Toyoda, A.; Fujiyama, A.; Tarutani, Y.; Kakutani, T.
10.1101/2022.12.19.521048 — genetics — Posted on 2022-12-20
1323 Age-dependent structural reorganization of utricular ribbon synapses
Wichmann, C.; Michanski, S.; Henneck, T.; Mukhopadhyay, M.; Steyer, A. M.; Gonzalez, P. A.; Grewe, K.; Ilgen, P.; Gültas, M.; Fornasiero, E. F.; Jakobs, S.; Möbius, W.; Vogl, C.; Pangrsic, T.; Rizzoli, S. O.
10.1101/2022.12.19.521049 — cell biology — Posted on 2022-12-20
1326 Missense variant interaction scanning reveals a critical role of the FERM-F3 domain for tumor suppressor protein NF2 conformation and function
Moesslacher, C. S.; Woodsmith, J.; Auernig, E.; Feichtner, A.; Jany-Luig, E.; Jehle, S.; Worseck, J. M.; Heine, C. L.; Stefan, E.; Stelzl, U.
10.1101/2022.12.11.519953 — systems biology — Posted on 2022-12-20
1327 Targeted Protein Degradation through E2 Recruitment
Forte, N.; Dovala, D.; Hesse, M. J.; McKenna, J. M.; Tallarico, J. A.; Schirle, M.; Nomura, D. K.
10.1101/2022.12.19.520812 — biochemistry — Posted on 2022-12-20
1329 Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis
Mary, B.; Asokan, N.; jerabkova-Roda, K.; Larnicol, A.; Busnelli, I.; Stemmelen, T.; Pichot, A.; Molitor, A.; Carapito, R.; Lefebvre, O.; GOETZ, J. G.; Hyenne, V.
10.1101/2022.12.19.521008 — cell biology — Posted on 2022-12-20
1330 Single nucleus and spatial transcriptomic profiling of human healthy hamstring tendon
Mimpen, J. Y.; Ramos-Mucci, L. D.; Paul, C.; Kurjan, A.; Hulley, P.; Ikwuanusi, C.; Gwilym, S.; Baldwin, M. J.; Cribbs, A. P.; Snelling, S. J. B.
10.1101/2022.12.19.521110 — cell biology — Posted on 2022-12-20
1331 A Parabrachial to Hypothalamic Pathway Mediates Defensive Behavior
Wang, F.; Chen, Y.; Lin, Y.; Wang, X.; Li, K.; Han, Y.; Wu, J.; Shi, X.; Zhu, Z.; Long, C.; Hu, X.; Duan, S.; Gao, Z.
10.1101/2022.06.01.494296 — neuroscience — Posted on 2022-12-20
1332 Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in GIST cells
Obata, Y.; Kurokawa, K.; Tojima, T.; Natsume, M.; Shiina, I.; Takahashi, T.; Abe, R.; Nakano, A.; Nishida, T.
10.1101/2022.12.19.520889 — cancer biology — Posted on 2022-12-20
1334 Redefining the connectome: A multi-modal, asymmetric, weighted, and signed description of anatomical connectivity
Tanner, J.; Faskowitz, J.; Teixeira, A. S.; Seguin, C.; Coletta, L.; Gozzi, A.; Misic, B.; Betzel, R.
10.1101/2022.12.19.519033 — neuroscience — Posted on 2022-12-19
1335 Limitation of amino acid availability by bacterial populations during enhanced colitis in IBD mouse model
Richie, T. G.; Heeren, L.; Kamke, A.; Pogranichniy, S.; Monk, K.; Summers, T.; Wiechman, H.; Ran, Q.; Sarkar, S.; Plattner, B.; Lee, S. T. M.
10.1101/2022.10.03.510649 — genomics — Posted on 2022-12-19
1336 Human mutations in SLITRK3 implicated in GABAergic synapse development in mice
Efthymiou, S.; Han, W.; Ilyas, M.; Li, J.; Yu, Y.; Scala, M.; Malintan, N.; Ilyas, M.; Vavouraki, N.; Mankad, K.; Maroofian, R.; Rocca, C.; Salpietro, V.; Lakhan, S.; J Mallack, E.; Palculict, T. B.; Li, H.; Zhang, G.; Zafar, F.; Rana, N.; Takashima, N.; Matsunaga, H.; Striano, P.; Lythgoe, M.; Arug, J.; Lu, W.; Houlden, H.
10.1101/2022.12.19.520993 — genetics — Posted on 2022-12-19
1337 Ghost admixture in eastern gorillas
Pawar, H.; Cuadros, S.; de Manuel, M.; van der Valk, T.; Lobon, I.; Alvarez-Estape, M.; Haber, M.; Dolgova, O.; Han, S.; Ayub, Q.; Bautista, R.; Kelley, J. L.; Cornejo, O. E.; Lao, O.; Andres, A. M.; Guschanski, K.; Ssebide, B.; Cranfield, M.; Tyler-Smith, C.; Xue, Y.; Prado-Martinez, J.; Marques-Bonet, T.; Kuhlwilm, M.
10.1101/2022.12.19.521012 — evolutionary biology — Posted on 2022-12-19
1338 How to tuna fish: constraint, convergence and integration in the neurocranium of pelagiarian fishes.
Knapp, A.; Rangel-de Lazaro, G.; Goswami, A.; Friedman, M.; Evans, K. M.; Giles, S.; Beckett, H. T.; Johanson, Z.
10.1101/2022.12.19.521082 — evolutionary biology — Posted on 2022-12-19
1339 E4F1 COORDINATES PYRUVATE METABOLISM AND THE ACTIVITY OF THE ELONGATOR COMPLEX TO ENSURE PROTEIN TRANSLATION FIDELITY DURING NEURONAL DEVELOPMENT
DiMichele, M.; Attina, A.; Laguesse, S.; DeBlasio, C.; Wendling, O.; Frenois, F. X.; Encislai, B.; Fuentes, M.; Talignani, C.; Rousseau, M.; Roux, P. F.; Guegan, J.; Buscail, Y.; Dupre, P.; Michaud, H. A.; Rodier, G.; Bellvert, F.; Kulyk, H.; Ferraro, C.; Mathieu, H.; Chaveroux, C.; Pirot, N.; Rubio, L.; Torro, A.; Compan, V.; Sorg, T.; Ango, F.; David, A.; Lebigot, E.; Legati, A.; Hirtz, C.; Ghezzi, D.; Nguyen, L.; Sardet, C.; Lacroix, M.; Lecam, L.
10.1101/2022.12.19.521032 — developmental biology — Posted on 2022-12-19
1341 Previously uncharacterized rectangular bacterial structures in the dolphin mouth
Dudek, N. K.; Galaz-Montoya, J. G.; Shi, H.; Mayer, M.; Danita, C.; Celis, A. I.; Viehboeck, T.; Wu, G.-H.; Behr, B.; Bulgheresi, S.; Huang, K. C.; Chiu, W.; Relman, D. A.
10.1101/2021.10.23.465578 — microbiology — Posted on 2022-12-19
1342 Chronic demyelination of rabbit lesions is attributable to failed oligodendrocyte progenitor cell repopulation.
Cooper, J. J. M.; Polanco, J. J.; Saraswat, D.; Peirick, J.; Seidl, A.; Li, Y.; Ma, D.; Sim, F.
10.1101/2022.01.21.477229 — neuroscience — Posted on 2022-12-19
1346 Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
Yu, Y.; Gao, S. M.; Guan, Y.; Hu, P.; Zhang, Q.; Liu, J.; Jing, B.; Zhao, Q.; Sabatini, D. M.; Abu-Remaileh, M.; Jung, S. Y.; Wang, M. C.
10.1101/2022.10.16.512400 — cell biology — Posted on 2022-12-19
1347 Backward masking in mice requires visual cortex
Gale, S.; Strawder, C.; Bennett, C.; Mihalas, S.; Koch, C.; Olsen, S. R.
10.1101/2021.09.26.461573 — neuroscience — Posted on 2022-12-19
1348 Associations of psychiatric disease and aging on FKBP5 expression converge on cortical supragranular neurons
Matosin, N.; Arloth, J.; Czamara, D.; Edmond, K. Z.; Maitra, M.; Froehlich, A. S.; Martinelli, S.; Kaul, D.; Bartlett, R.; Curry, A. R.; Gassen, N.; Hafner, K.; Mueller, N.; Worf, K.; Rehawi, G.; Nagy, C.; Halldorsdottir, T.; Cruceanu, C.; Gagliardi, M.; Gerstner, N.; Koedel, M.; Murek, V.; Ziller, M. J.; Scarr, E.; Tao, R.; Jaffe, A. E.; Arzberger, T.; Falkai, P.; Kleinmann, J.; Weinberger, D.; Mechawar, N.; Schmitt, A.; Dean, B.; Turecki, G.; Hyde, T. M.; Binder, E.
10.1101/2021.01.27.428487 — neuroscience — Posted on 2022-12-19
1349 marmite defines a novel conserved neuropeptide family mediating nutritional homeostasis
Francisco, A. P.; Tastekin, I.; Fernandes, A. B.; Ezra-Nevo, G.; Deplancke, B.; Oliveira-Maia, A. J.; Gontijo, A. M.; Ribeiro, C.
10.1101/2022.12.12.520095 — neuroscience — Posted on 2022-12-19
1350 Clathrin-mediated Endocytosis Facilitates Internalization of Magnaporthe oryzae Effectors into Rice Cells
Oliveira-Garcia, E.; Tamang, T. M.; Park, J.-E.; Dalby, M.; Martin-Urdiroz, M.; Rodriguez Herrero, C.; Hong Vu, A.; Park, S.; Talbot, N. J.; Valent, B.
10.1101/2021.12.28.474284 — plant biology — Posted on 2022-12-19
1351 Detection of PatIent-Level distances from single cell genomics and pathomics data with Optimal Transport (PILOT)
Joodaki, M.; Shaigan, M.; Parra, V.; D. Buelow, R.; Kuppe, C.; L. Holscher, D.; Cheng, M.; S. Nagai, J.; Bouteldja, N.; Tesar, V.; Barratt, J.; Roberts, I. S. D.; Coppo, R.; Kramann, R.; Boor, P.; G. Costa, I.
10.1101/2022.12.16.520739 — bioinformatics — Posted on 2022-12-19
1356 Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome
Shin, H.; Leung, A.; Costello, K. R.; Senapati, P.; Kato, H.; Lee, M.; Lin, D.; Tang, X.; Chen, Z. B.; Schones, D. E.
10.1101/2022.05.11.491514 — molecular biology — Posted on 2022-12-19
1358 Deep divergence and genomic diversification of gut symbionts of neotropical stingless bees
Sarton-Loheac, G.; Nunes da Silva, C. G.; Mazel, F.; Baud, G.; de Bakker, V.; Das, S.; El Chazli, Y.; Ellegaard, K. M.; Garcia-Garcera, M.; Glover, N. M.; Liberti, J. M.; Nacif Marcal, L.; Prasad, A.; Somerville, V.; SAGE class 2019-2020 and 2020-2021, ; Bonilla Rosso, G.; Engel, P.
10.1101/2022.12.08.519137 — microbiology — Posted on 2022-12-19
1359 Guanine crystals discovered in bacteria
Pavan, M. E.; Movilla, F.; Pavan, E.; Di Salvo, F.; Lopez, N. I.; Pettinari, M. J.
10.1101/2022.12.02.518751 — microbiology — Posted on 2022-12-19
1360 T cell Aryl Hydrocarbon Receptor Activity Tunes the Gut Microenvironment to Sustain Autoimmunity.
Merchak, A. R.; Cahill, H. J.; Brown, L. C.; Brown, R. M.; Rivet-Noor, C.; Beiter, R. M.; Slogar, E. R.; Olgun, D. G.; Gaultier, A.
10.1101/2022.04.19.488821 — immunology — Posted on 2022-12-19
1361 Long-range alpha-synchronisation as control signal for BCI: A feasibility study
Esparza-Iaizzo, M.; Vigue-Guix, I.; Ruzzoli, M.; Torralba Cuello, M.; Soto-Faraco, S.
10.1101/2022.05.25.493035 — neuroscience — Posted on 2022-12-19
1362 Neural circuitry for maternal oxytocin release induced by infant cries
Valtcheva, S.; Issa, H. A.; Bair-Marshall, C. J.; Martin, K. A.; Jung, K.; Buzsaki, G.; Zhang, Y.; Kwon, H.-B.; Froemke, R. C.
10.1101/2021.03.25.436883 — neuroscience — Posted on 2022-12-19
1363 Characterization of cardiac-induced noise in R2* maps of the brain
Raynaud, Q.; Di Domenicantonio, G.; Yerly, J.; Dardano, T.; van Heeswijk, R. B.; Lutti, A.
10.1101/2022.12.19.521028 — neuroscience — Posted on 2022-12-19
1364 Mechanistic model-driven exometabolomic characterisation of human dopaminergic neuronal metabolism
Preciat, G.; Wegrzyn, A.; Moreno, E. L.; Willacey, C. C. W.; Modamio, J.; Monteiro, F. L.; El Assal, D.; Schurink, A.; Oliveira, M. A. P.; Zhang, Z.; Cousins, B.; Haraldsdottir, H. S.; Hachi, S.; Zach, S.; Leparc, G.; Lee, Y. T.; Hengerer, B.; Vempala, S.; Saunders, M. A.; Harms, A.; Glaab, E.; Schwamborn, J. C.; Thiele, I.; Hankemeier, T.; Fleming, R. M.
10.1101/2021.06.30.450562 — systems biology — Posted on 2022-12-19
1367 Capturing variation in metagenomic assembly graphs with MetaCortex
Martin, S.; Ayling, M.; Patrono, L.; Caccamo, M.; Murcia, P.; Leggett, R. M.
10.1101/2021.07.23.453484 — bioinformatics — Posted on 2022-12-19
1368 Small Molecule Properties Define Partitioning into Biomolecular Condensates
Thody, S. A.; Clements, H. D.; Baniasadi, H.; Lyon, A. S.; Sigman, M. S.; Rosen, M. K.
10.1101/2022.12.19.521099 — biochemistry — Posted on 2022-12-19
1374 The Kelch13 compartment is a hub of highly divergent vesicle trafficking proteins in malaria parasites
Schmidt, S.; Wichers-Misterek, J. S.; Behrens, H. M.; Birnbaum, J.; Henshall, I.; Jonscher, E.; Flemming, S.; Castro-Pena, C.; Spielmann, T.
10.1101/2022.12.15.520209 — cell biology — Posted on 2022-12-19
1375 Whole Organism Profiling of the Timp Gene Family
Peeney, D.; Fan, Y.; Gurung, S.; Lazaroff, C.; Ratnayake, S.; Warner, A.; Karim, B.; Meerzaman, D.; Stetler-Stevenson, W. G.
10.1101/2021.10.15.464572 — cell biology — Posted on 2022-12-19
1377 Improved discovery of RNA-binding protein binding sites in eCLIP data using DEWSeq
Schwarzl, T.; Sahadevan, S.; Lang, B.; Miladi, M.; Backofen, R.; Huber, W.; Hentze, M.; Tartaglia, G. G.
10.1101/2022.11.15.516416 — molecular biology — Posted on 2022-12-19
1379 Genes and genome-resolved metagenomics reveal the microbial functional make up of Amazon peatlands under geochemical gradients
Pavia, M. J.; Finn, D.; Macedo-Tafur, F.; Tello-Espinoza, R.; Penaccio, C.; Bouskill, N.; Cadillo-Quiroz, H.
10.1101/2022.12.19.521090 — microbiology — Posted on 2022-12-19
1380 Skin microbiota dynamics of dairy cows affected by digital dermatitis
Ariza, J. M.; Dopfer, D.; Oberle, K.; Anklam, K.; Labrut, S.; Bareille, N.; Relun, A.; Guatteo, R.
10.1101/2019.12.20.882787 — microbiology — Posted on 2022-12-19
1383 Sphingolipids protect ergosterol in the Leishmania major membrane from sterol-binding toxins
Haram, C.; Moitra, S.; Keane, R.; Kuhlmann, F. M.; Frankfater, C.; Hsu, F.-f.; Beverley, S. M.; Zhang, K.; Keyel, P. A.
10.1101/2022.06.15.496300 — microbiology — Posted on 2022-12-19
1386 Top-down specific preparatory activations for Selective Attention and Perceptual Expectations
G. Penalver, J. M.; Lopez-Garcia, D.; Gonzalez-Garcia, C.; Aguado-Lopez, B.; Gorriz, J. M.; Ruz, M.
10.1101/2022.09.13.507583 — neuroscience — Posted on 2022-12-19
1387 Functional dissociations between prefrontal and parietal cortex during task switching: A combined fMRI and TMS study
Perianez, J. A.; Viejo-Sobera, R.; Lubrini, G.; Alvarez-Linera, J.; Rodriguez Toscano, E.; Moreno, M. D.; Arango, C.; Redolar-Ripoll, D.; M. Marron, E.; Rios-Lago, M.
10.1101/2022.12.15.520659 — neuroscience — Posted on 2022-12-19
1388 EEG-LLAMAS: an open source, low latency, EEG-fMRI neurofeedback platform
Levitt, J.; Yang, Z.; Williams, S. D.; Lutschg Espinosa, S. E.; Garcia-Casal, A.; Lewis, L.
10.1101/2022.11.21.515651 — neuroscience — Posted on 2022-12-19
1390 The K+ exchange antiporter 3 senses the chloroplast energy status to synchronize photosynthesis
Uflewski, M.; Rindfleisch, T.; Korkmaz, K.; Tietz, E.; Mielke, S.; Galvis, V. C.; Duenschede, B.; Luzarowski, M.; Skirycz, A.; Schwarzlaender, M.; Strand, D. D.; Hertle, A. P.; Schuenemann, D.; Walther, D.; Wolff, M.; Thalhammer, A.; Armbruster, U.
10.1101/2022.12.19.521033 — plant biology — Posted on 2022-12-19
1392 Effect of insulin insufficiency on ultrastructure and function in skeletal muscle
Kopecky, C.; Haug, M.; Reischl, B.; Deshpande, N.; Manandhar, B.; King, T.; Lee, V.; Wilkins, M.; Morris, M. J.; Polly, P.; Friedrich, O.; Rye, K.-A.; Cochran, B. J.
10.1101/2022.12.18.520900 — physiology — Posted on 2022-12-19
1393 Diclofenac and other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are Competitive Antagonists of the human P2X3 Receptor
Grohs, L.; Cheng, L.; Coenen, S.; Haddad, B.; Obrecht, A.; Toklucu, I.; Ernst, L.; Koerner, J.; Schmalzing, G.; Lampert, A.; Machtens, J.-P.; Hausmann, R.
10.1101/2022.12.19.520978 — pharmacology and toxicology — Posted on 2022-12-19
1399 Indole produced during dysbiosis mediates host-microorganism chemical
Yang, R.-q.; Chen, Y.-h.; Wu, Q.-y.; Tang, J.; Niu, S.-z.; Zhao, Q.; Ma, Y.-c.; Zou, C.-g.
10.1101/2022.12.19.520989 — biochemistry — Posted on 2022-12-19
1400 FAP-retargeted Ad5 enables in vivo gene delivery to stromal cells in the tumor microenvironment
Hartmann, K. P.; van Gogh, M.; Freitag, P. C.; Kast, F.; Nagy-Davidescu, G.; Borsig, L.; Plueckthun, A.
10.1101/2022.12.19.520931 — biochemistry — Posted on 2022-12-19
1402 Subtle introgression footprints at the end of the speciation continuum in a clade of Heliconius butterflies
Rougemont, Q.; Huber, B.; Martin, S. H.; Whibley, A.; Estrada, C.; Solano, D.; Orpet, R.; McMillan, W. O.; Frerot, B.; Joron, M.
10.1101/2022.12.19.520581 — evolutionary biology — Posted on 2022-12-19
1403 The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut
Russell, A. L.; Donovan, E.; Sielhamer, N.; Siegrist, M.; Franklin, C. L.; Ericsson, A. C.
10.1101/2022.12.19.521059 — developmental biology — Posted on 2022-12-19
1406 A high-impact COL6A3 mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loading
Bloks, N. G. C.; Harissa, Z.; Adkar, S. S.; Dicks, A.; Hajmousa, G.; Steward, N.; Koning, R. I.; Mulder, A.; de Koning, B. B. R.; Kloppenburg, M.; Coutinho de Almeida, R.; Ramos, Y. F. M.; Guilak, F.; Meulenbelt, I.
10.1101/2022.12.19.520461 — molecular biology — Posted on 2022-12-19
1407 SpyDisplay: A Versatile Phage Display Selection System using SpyTag/SpyCatcher Technology
Kellmann, S.-J.; Hentrich, C.; Putyrski, M.; Hanuschka, H.; Cavada, M.; Knappik, A.; Ylera, F.
10.1101/2022.12.19.520987 — molecular biology — Posted on 2022-12-19
1412 Cuticle architecture and mechanical properties: a functional relationship delineated through correlated multimodal imaging
Reynoud, N.; Geneix, N.; D'Orlando, A.; Petit, J.; Mathurin, J.; Deniset-Besseau, A.; Marion, D.; Rothan, C.; Lahaye, M.; Bakan, B.
10.1101/2022.12.19.521062 — plant biology — Posted on 2022-12-19
1415 novoRNABreak: local assembly for novel splice junction and fusion transcript detection from RNA-seq data
Tan, Y.; Mohanty, V.; Liang, S.; Ma, J.; Kim, K. H.; Bonder, M. J.; Shi, X.; Lee, C.; Chong, Z.; Chen, K.
10.1101/2022.12.16.520791 — bioinformatics — Posted on 2022-12-19
1417 Intramolecular autoinhibition of human PEX13 modulates peroxisomal import
Gaussmann, S.; Ott, J.; Zak, K. M.; Delhommel, F.; Popowicz, G.; Schliebs, W.; Erdmann, R.; Sattler, M.
10.1101/2022.12.19.520972 — biochemistry — Posted on 2022-12-19
1418 An Amber-Encoding Helper Phage for More Efficient Phage Display of Noncanonical Amino Acids
Hampton, J. T.; Cho, C.-C.; Geng, Z. Z.; Coleman, D. D.; Chen, P.-H. C.; Dubey, G. K.; Sylvain, L. D.; Xu, S.; Liu, W. R.
10.1101/2022.12.19.521047 — biochemistry — Posted on 2022-12-19
1420 The pan-genome and local adaptation of Arabidopsis thaliana
Kang, M.; Wu, H.; Liu, W.; Zhu, M.; Han, Y.; Liu, W.; Chen, C.; Yin, K.; Zhao, Y.; Yan, Z.; Liu, H.; Lou, S.; Zan, Y.; Liu, J.
10.1101/2022.12.18.520013 — genomics — Posted on 2022-12-19
1421 Continent-wide phylogenomic framework reveals introgression as a driver of intra-specific diversity and enriched molecular pathways in caribou
Taylor, R. S.; Manseau, M.; Keobouasone, S.; Mastromonaco, G.; Solmundson, K.; Kelly, A.; Larter, N. C.; Gamberg, M.; Schwantje, H.; Thacker, C.; Polfus, J.; Andrew, L.; Hervieux, D.; Simmons, D.; Wilson, P. J.
10.1101/2022.12.19.521038 — genomics — Posted on 2022-12-19
1422 Quantifying constraint in human mitochondrial DNA
Lake, N. J.; Liu, W.; Battle, S. L.; Laricchia, K. M.; Tiao, G.; Compton, A. G.; Cowie, S.; Christodoulou, J.; Thorburn, D. R.; Zhao, H.; Arking, D. E.; Sunyaev, S. R.; Lek, M.
10.1101/2022.12.16.520778 — genetics — Posted on 2022-12-19
1423 DNMT3B PWWP mutations cause hypermethylation of heterochromatin
Taglini, F.; Kafetzopoulos, I.; Musialik, K. I.; Lee, H. Y.; Zhang, Y.; Marenda, M.; Kerr, L.; Finan, H.; Rubio-Ramon, C.; Wapenaar, H.; Davidson-Smith, H.; Wills, J.; Murphy, L. C.; Wheeler, A.; Wilson, M. D.; Sproul, D.
10.1101/2022.12.19.521050 — genetics — Posted on 2022-12-19
1426 Focal adhesion assembly requires phosphorylation signaling
Kumar, S.; Stainer, A.; Dubrulle, J.; Simpkins, C.; Cooper, J.
10.1101/2022.12.19.521109 — cell biology — Posted on 2022-12-19
1427 Unique functional responses differentially map onto genetic subtypes of dopamine neurons
Azcorra, M.; Gaertner, Z.; Davidson, C.; Hayes, C. K.; Ramakrishnan, C.; Fenno, L.; Kim, Y. S.; Deisseroth, K.; Longnecker, R.; Awatramani, R.; Dombeck, D. A.
10.1101/2022.12.19.521076 — neuroscience — Posted on 2022-12-19
1428 Multi-modal and multi-model interrogation of large-scale functional brain networks
Castaldo, F.; Pascoa dos Santos, F.; Timms, R.; Cabral, J.; Vohryzek, j.; Deco, G.; Woolrich, M.; Friston, K.; Verschure, P.; Litvak, V.
10.1101/2022.12.19.520967 — neuroscience — Posted on 2022-12-19
1429 Hippocampal ripples coincide with ''up-state'' and cortical spindles in Retrosplenial Cortex
Pedrosa, R.; Nazari, M.; Kergoat, L.; Bernard, C.; Mohajerani, M.; Stella, F.; Battaglia, F.
10.1101/2022.12.19.521088 — neuroscience — Posted on 2022-12-19
1431 Rewarding capacity of optogenetically activating a giant GABAergic central-brain interneuron in larval Drosophila
Mancini, N.; Thoener, J.; Tafani, E.; Pauls, D.; Mayseless, O.; Strauch, M.; Eichler, K.; Champion, A.; Kobler, O.; Weber, D.; Sen, E.; Weiglein, A.; Hartenstein, V.; Thum, A. S.; Rohwedder, A.; Schleyer, M.; Gerber, B.
10.1101/2022.12.19.521052 — neuroscience — Posted on 2022-12-19
1433 Distinct spatial maps and multiple object codes in the lateral entorhinal cortex
Huang, X.; Schlesiger, M. I.; Barriuso-Ortega, I.; Leibold, C.; MacLaren, D. A. A.; Bieber, N.; Monyer, H.
10.1101/2022.12.19.521018 — neuroscience — Posted on 2022-12-19
1435 A duration-dependent interaction between high-intensity light and optical refocus in the drive for myopia control
Biswas, S.; Muralidharan, A. R.; Betzler, B. K.; Busoy, J. M. F.; Veluchamy, A. B.; Tan, R. K. Y.; Low, W. Y. S.; Milea, D.; Kathrani, B. K.; Brennan, N. A.; Najjar, R. P.
10.1101/2022.12.19.520946 — neuroscience — Posted on 2022-12-19
1437 LRRK2 Kinase Activity Regulates Parkinson's Disease-Relevant Lipids at the Lysosome
Maloney, M. T.; Wang, X.; Ghosh, R.; Andrews, S. V.; Maciuca, R.; Masoud, S. T.; Caprioli, R. M.; Chen, J.; Chiu, C.-L.; Davis, S. S.; Ho, A. C.-N.; Nguyen, H. N.; Propson, N. E.; Reyzer, M. L.; Davis, O. B.; Deen, M. C.; Zhu, S.; Di Paolo, G.; Vocadlo, D. J.; Estrada, A. A.; de Vicente, J.; Lewcock, J. W.; Arguello, A.; Suh, J. H.; Huntwork-Rodriguez, S.; Henry, A. G.
10.1101/2022.12.19.521070 — neuroscience — Posted on 2022-12-19
1439 Homeostasis, injury and recovery dynamics at multiple scales in a self-organizing intestinal crypt
Gall, L.; Duckworth, C.; Jardi, F.; Lammens, L.; Parker, A.; Bianco, A.; Kimko, H.; Pritchard, D. M.; Pin, C.
10.1101/2022.12.18.520934 — systems biology — Posted on 2022-12-19
1442 Genetic basis and selection of glyceollin induction in wild soybean
Yasmin, F.; Zhang, H.; Leamy, L.; Wang, B.; Winnike, J.; Reid, R. W.; Brouwer, C. R.; Song, B.-H.
10.1101/2022.12.17.520864 — plant biology — Posted on 2022-12-19
1443 A hormone-activated mobile RNAi pathway defends plant stem cells from virus infection
Incarbone, M.; Bradamante, G.; Pruckner, F.; Wegscheider, T.; Rozhon, W.; Nguyen, V.; Gutzat, R.; Lendl, T.; MacFarlane, S.; Nodine, M.; Scheid, O. M.
10.1101/2022.12.18.520928 — plant biology — Posted on 2022-12-19
1445 Injury and a program of fetal wound healing in the fetal and neonatal extrahepatic bile duct
de Jong, I. E. M.; Hunt, M. L.; Chen, D.; Du, Y.; Llewellyn, J.; Gupta, K.; Erxleben, D. A.; Rivas, F.; Hall, A. R.; Furth, E. E.; Naji, A.; Liu, C.; Dhand, A.; Burdick, J. A.; Davey, M. G.; Flake, A. W.; Porte, R. J.; Russo, P. A.; Gaynor, J. W.; Wells, R. G.
10.1101/2022.12.15.520656 — physiology — Posted on 2022-12-19
1446 Age but not menopausal status is linked to lower resting energy expenditure
Karppinen, J. E.; Wiklund, P.; Ihalainen, J. K.; Juppi, H.-K.; Isola, V.; Hyvarinen, M.; Ahokas, E. K.; Kujala, U. M.; Laukkanen, J. A.; Hulmi, J. J.; Ahtiainen, J. P.; Cheng, S.; Laakkonen, E. K.
10.1101/2022.12.16.520683 — physiology — Posted on 2022-12-19
1448 Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents
Kriegeskorte, S.; Bott, R.; Hampl, M.; Korngreen, A.; Hausmann, R.; Lampert, A.
10.1101/2022.12.19.521077 — physiology — Posted on 2022-12-19
1449 Optimizing tuberculosis treatment efficacy: comparing the standard regimen with Moxifloxacin-containing regimens
Budak, M.; Cicchese, J. M.; Maiello, P.; Borish, H. J.; White, A. G.; Chishti, H. B.; Tomko, J.; Frye, L. J.; Fillmore, D.; Kracinovsky, K.; Sakal, J.; Scanga, C. A.; Lin, P. L.; Dartois, V.; Linderman, J. J.; Flynn, J. L.; Kirschner, D. E.
10.1101/2022.12.18.520959 — pharmacology and toxicology — Posted on 2022-12-19
1451 Mechanical regulation of retinal vascular inflammation and degeneration in diabetic retinopathy
Chandrakumar, S.; Santiago Tierno, I.; Agarwal, M.; Lessieur, E. M.; Du, Y.; Tang, J.; Kiser, J.; Yang, X.; Kern, T. S.; Ghosh, K.
10.1101/2022.12.18.520943 — pathology — Posted on 2022-12-19
1452 Truncated KDM6A exhibits differential chromatin occupancy and regulatory interactions
Ozden Yilmaz, G.; Savas, B.; Bursali, A.; Eray, A.; Aribas, A.; Senturk, S.; Karaca, E.; Karakulah, G.; Erkek Ozhan, S.
10.1101/2022.12.19.520968 — cancer biology — Posted on 2022-12-19
1454 ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer
Schultz, C. W.; Zhang, Y.; Elmeskini, R.; Zimmermann, A.; Fu, H.; Murai, Y.; Wangsa, D.; Kumar, S.; Takahashi, N.; Atkinson, D.; Saha, L. K.; Lee, C.-F.; Elenbaas, B.; Desai, P.; Sebastian, R.; Ried, T.; Aladjem, M.; Zenke, F. T.; Weaver, Z.; Pommier, Y.; Thomas, A.
10.1101/2022.12.16.520783 — cancer biology — Posted on 2022-12-19
1456 Single-Cell Analysis of 5-ALA Intraoperative Labeling Specificity for Glioblastoma
Liu, Z.; Mela, A.; Furnari, J.; Kotidis, C.; Sperring, C.; Humala, N.; Bruce, J. N.; Canoll, P.; Sims, P. A.
10.1101/2022.12.17.520870 — cancer biology — Posted on 2022-12-19
1458 MultiGML: Multimodal Graph Machine Learning for Prediction of Adverse Drug Events
Krix, S.; DeLong, L. N.; Madan, S.; Domingo-Fernandez, D.; Ahmad, A.; Gul, S.; Zaliani, A.; Frohlich, H.
10.1101/2022.12.16.520738 — bioinformatics — Posted on 2022-12-19
1460 Synthetic whole-slide image tile generation with gene expression profiles infused deep generative models
Carrillo-Perez, F.; Pizurica, M.; Ozawa, M. G.; Vogel, H.; West, R. B.; Kong, C.; Herrera, L. J.; Shen, J.; Gevaert, O.
10.1101/2022.12.16.520705 — bioinformatics — Posted on 2022-12-19
1465 Open-3DSIM: an Open-source three-dimensional structured illumination microscopy reconstruction platform
Cao, R.; Li, Y.; Chen, X.; Ge, X.; Li, M.; Guan, M.; Hou, Y.; Fu, Y.; Jiang, S.; Gao, B.; Xi, P.
10.1101/2022.12.16.520543 — bioengineering — Posted on 2022-12-19
1466 A patterned human heart tube organoid model generated by pluripotent stem cell self-assembly
Volmert, B.; Aguirre, A.; Riggs, A.; Wang, F.; Juhong, A.; Kiselev, A.; Kostina, A.; O'Hern, C.; Muniyandi, P.; Wasserman, A.; Huang, A.; Lewis-Israeli, Y.; Park, S.; Qiu, Z.; Zhou, C.
10.1101/2022.12.16.519611 — bioengineering — Posted on 2022-12-19
1467 Physiology and mathematical modeling of immobilized Saccharomyces spp. in beer fermentation
Araujo, T. M. d.; Cunha, M. M. L. d.; Barga, M. C.; Della-Bianca, B. E.; Basso, T. O.
10.1101/2022.12.17.520861 — bioengineering — Posted on 2022-12-19
1468 Label-free and high-throughput removal of residual undifferentiated cells from iPSC-derived spinal-cord progenitor cells
Nguyen, T. D.; Chooi, W. H.; Jeon, H.; Chen, J.; Roxby, D. N.; Tan, J.; Lee, C. Y.-P.; Ng, S.-Y.; Han, J.; Chew, S. Y.
10.1101/2022.12.16.520699 — bioengineering — Posted on 2022-12-19
1469 An auto-release mechanism for HMCES-DNA-protein crosslinks
Donsbach, M.; Dürauer, S.; Nguyen, K. T.; Grünert, F.; Yaneva, D.; Semlow, D.; Stingele, J.
10.1101/2022.12.18.520715 — biochemistry — Posted on 2022-12-19
1470 Chemoproteomics yields a selective molecular host for acetyl-CoA
Lieberman, W. K.; Brown, Z. A.; Jing, Y.; Evans, N. D.; Jhulki, I.; Grose, C.; Jones, J. e.; Meier, J. L.
10.1101/2022.12.19.521087 — biochemistry — Posted on 2022-12-19
1471 Biochemical activity is the default DNA state in eukaryotes
Luthra, I.; Chen, X. E.; Jensen, C.; Rafi, A. M.; Salaudeen, A. L.; de Boer, C. G.
10.1101/2022.12.16.520785 — genomics — Posted on 2022-12-19
1472 Patterns of gene expression and allele-specific expression vary among macular tissues and clinical stages of Age-related Macular Degeneration
Zhang, C.; Barr, J. L.; Owen, L. A.; Shakoor, A.; Vitale, A.; Lillvis, J. H.; Husami, N.; Cromwell, P.; Finley, R.; Au, E.; Haider, N. B.; Zavala, R. A.; Graves, E. C.; Li, M.; Tawkif, A.; Zhang, S. X.; Stambolian, D.; Farkas, M. H.; Kim, I. K.; Sherva, R.; Farrer, L.; DeAngelis, M. M.
10.1101/2022.12.19.521092 — genomics — Posted on 2022-12-19
1474 A refined characterization of large-scale genomic differences in the first complete human genome
Yang, X.; Wang, X.; Zou, Y.; Zhang, S.; Xia, M.; Vollger, M. R.; Chen, N.-C.; Taylor, D. J.; Harvey, W. T.; Logsdon, G. A.; Meng, D.; Shi, J.; McCoy, R. C.; Schatz, M. C.; Li, W.; Eichler, E. E.; Lu, Q.; Mao, Y.
10.1101/2022.12.17.520860 — genomics — Posted on 2022-12-19
1475 Comprehensive profiling of wastewater viromes by genomic sequencing
Wyler, E.; Lauber, C.; Manukyan, A.; Deter, A.; Quedenau, C.; Teixeira Alves, L. G.; Seitz, S.; Altmüller, J.; Landthaler, M.
10.1101/2022.12.16.520800 — genomics — Posted on 2022-12-19
1476 Uncovering hidden genetic diversity: allelic resolution of insect and spider silk genes
Frandsen, P. B.; Hotaling, S.; Powell, A.; Heckenhauer, J. B.; Kawahara, A. Y.; Baker, R. H.; Hayashi, C. Y.; Rios-Touma, B.; Holzenthal, R.; Pauls, S. U.; Stewart, R. J.
10.1101/2022.12.17.520845 — genomics — Posted on 2022-12-19
1481 Genomic insights into Plasmodium vivax population structure and diversity in central Africa
Gartner, V.; Redelings, B. D.; Gaither, C.; Parr, J. B.; Kalonji, A.; Phanzu, F.; Brazeau, N. F.; Juliano, J. J.; Wray, G. A.
10.1101/2022.12.16.520826 — evolutionary biology — Posted on 2022-12-19
1488 The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress
Anerillas, C.; Mazan-Mamczarz, K.; Herman, A. B.; Munk, R.; Lam, G. K.; Calvo-Rubio, M.; Garrido, A.; Tsitsipatis, D.; Martindale, J. L.; Altes, G.; Rossi, M.; Piao, Y.; Fan, J.; Cui, C.-Y.; De, S.; Abdelmohsen, K.; de Cabo, R.; Gorospe, M.
10.1101/2022.12.18.520921 — cell biology — Posted on 2022-12-19
1489 Control of stereocilia length during development of hair bundles
Krey, J. F.; Chatterjee, P.; Halford, J.; Cunningham, C. L.; Perrin, B. J.; Barr-Gillespie, P. G.
10.1101/2022.12.18.520962 — cell biology — Posted on 2022-12-19
1490 Calcium flux through ER-TGN contact sites facilitates cargo export
Ramazanov, B. R.; Di Martino, R.; Kumar, A.; PARCHURE, A.; Kim, Y.; Griesbeck, O.; Schwartz, M. A.; Luini, A.; von Blume, J.
10.1101/2022.12.19.521097 — cell biology — Posted on 2022-12-19
1491 Isolation and characterization of Ovine gammaherpesvirus type 2 from an outbreak of Malignant Catarrhal Fever in Artiodactyla and horses in Mexico.
Madrigal-Valencia, T. L.; Saavedra-Montanez, M.; Perez-Torres, A.; Hernandez, J.; Segales, J.; Hernandez, Y. D.; Candanosa-Aranda, I. E.; Perez-Guiot, A.; Ramirez-Mendoza, H.
10.1101/2022.12.18.520964 — microbiology — Posted on 2022-12-19
1493 Development of a high-throughput barrier function assay using primary human gut organoids
Wright, C. W.; Li, N.; Shaffer, L.; Hill, A.; Boyer, N.; Alves, S.; Venkat, S.; Biswas, K.; Lieberman, L. A.; Mohammadi, S.
10.1101/2022.12.16.520780 — immunology — Posted on 2022-12-19
1494 Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells
Rodriguez, C.; Araujo Furlan, C. L.; Tosello Boari, J.; Bossio, S. N.; Boccardo, S.; Fozzatti, L.; Canale, F. P.; Beccaria, C. G.; Nunez, N. G.; Ceschin, D. G.; Piaggio, E.; Gruppi, A.; Montes, C. L.; Acosta Rodriguez, E. V.
10.1101/2022.12.16.520754 — immunology — Posted on 2022-12-19
1496 Decoupled neoantigen cross-presentation in tumors with high intratumor heterogeneity reduces dendritic cell activation to limit anti-tumor immunity
Nguyen, K. B.; Copeland, C. J.; Backlund, C. M.; Klop-Packel, N. G.; Remba, T.; Kim, B.; Singh, N. K.; Birnbaum, M. E.; Irvine, D. J.; Spranger, S.
10.1101/2022.12.16.520773 — immunology — Posted on 2022-12-19
1498 Clonally-Expanded, Thyrotoxic Autoimmune Mediator CD8+ T cells Driven by IL21 Contribute to Checkpoint Inhibitor Thyroiditis
Lechner, M. G.; Zhou, Z.; Hoang, A. T.; Huang, N.; Ortega, J.; Scott, L. N.; Chen, H.-C.; Patel, A. Y.; Tafti, R. Y.; Kim, K.; Hugo, W.; Famini, P.; Drakaki, A.; Ribas, A.; Angell, T. E.; Su, M. A.
10.1101/2022.12.18.517398 — immunology — Posted on 2022-12-19
1499 Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques
Rahmberg, A. R.; Wu, C.; Shin, T.; Hong, S. G.; Pei, L.; Hickman, H. D.; Dunbar, C. E.; Brenchley, J. M.
10.1101/2022.12.19.521067 — immunology — Posted on 2022-12-19
1500 Psychopathy and distance estimation
Michalareas, G.; Lehr, C.; Grabenhorst, M.; Hecht, H.
10.1101/2022.12.16.520720 — neuroscience — Posted on 2022-12-19
1502 Capturing the pathomechanisms of different disease severities in a human cerebral organoid model of LIS1-lissencephaly
Rossetti, A. C.; Fechtner, O.; Maillard, C.; Hoffrichter, A.; Zillich, L.; Poisel, E.; Jabali, A.; Marsoner, F.; Wilkens, R.; Francis, F.; Bahi-Buisson, N.; Koch, P.; Ladewig, J.
10.1101/2022.12.19.520907 — neuroscience — Posted on 2022-12-19
1503 PRE-INJURY MECHANORECEPTOR ABLATION REDUCES NOCICEPTOR-DRIVEN SPINAL CORD INJURY-INDUCED NEUROPATHIC PAIN
Sliwinski, C.; Heutehaus, L.; Taberner, F. J.; Weiss, L.; Kampanis, V.; Tolou-Dabbaghian, B.; Cheng, X.; Motsch, M.; Heppenstall, P. A.; Kuner, R.; Franz, S.; Lechner, S. G.; Weidner, N.; Puttagunta, R.
10.1101/2022.12.18.520950 — neuroscience — Posted on 2022-12-19
1506 A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor
Perina, M.; Kiss, M. A.; Motyan, G.; Szczyrbova, E.; Elias, M.; Student, V.; Kurfurstova, D.; Kovalova, M.; Mada, L.; Bouchal, J.; Frank, E.; Jorda, R.
10.1101/2022.12.17.520850 — pharmacology and toxicology — Posted on 2022-12-19
1507 Disorganization of basement membrane zone architecture causes impaired melanocyte inhabitation in vitiligo
Yang, F.; Yang, L.; Kuroda, Y.; Lai, S.; Takahashi, Y.; Sayo, T.; Namiki, T.; Nakajima, K.; Sano, S.; Inuoe, S.; Tsuruta, D.; Katayama, I.
10.1101/2022.12.18.520911 — pathology — Posted on 2022-12-19
1509 CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to Navitoclax
Neault, M.; Lebert-Ghali, C.-E.; Fournier, M.; Capdevielle, C.; Garfinkle, E. A. R.; Obermayer, A.; Cotton, A.; Boulay, K.; Sawchyn, C.; Nguyen, K. H.; Assaf, B.; Mercier, F. E.; Delisle, J.-S.; Drobetsky, E. A.; Hulea, L.; Shaw, T. I.; Zuber, J.; Gruber, T. A.; Melichar, H. J.; Mallette, F. A.
10.1101/2022.12.16.520129 — cancer biology — Posted on 2022-12-19
1510 Single-cell RNA sequencing analyses of primary cutaneous B-cell disorders reveal distinct molecular patterns consistent with clinical behavior
Griss, J.; Drach, M. C.; Nguyen, V.; Levine, J. P.; Thaler, F.; Medjimorec, M. A.; Shaw, L. E.; Mann, U.; Weninger, W.; Wagner, C.; Wagner, S.; Simonitsch-Klupp, I.; Farlik, M.; Jonak, C.; Brunner, P. M.
10.1101/2022.12.16.520801 — cancer biology — Posted on 2022-12-19
1511 Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population
Regal, J. A.; Guerra Garcia, M. E.; Jain, V.; Chandramohan, V.; Ashley, D. M.; Gregory, S. G.; Thompson, E. M.; Lopez, G. Y.; Reitman, Z. J.
10.1101/2022.12.17.520880 — cancer biology — Posted on 2022-12-19
1512 Analysis of gene expression heterogeneity reveals therapeutic targets and novel regulators of metastasis
Yang, D.; Dann, C.; Valdespino, A.; Robinson-Mailman, L.; Henn, M.; Chen, M.; Balazsi, G.; Rosner, M. R.
10.1101/2022.12.16.520816 — cancer biology — Posted on 2022-12-19
1514 Protein Language Model for Prediction of Subcellular Localization of Protein Sequences from Gram-negative bacteria (ProtLM.SCL)
Singh, G.; Tyagi, R.; Singh, A.; Kapil, S.; Parida, P. K.; Scarcelli, M.; Dumitru, D.; Sathiyamoorthy, N. K.; Phogat, S.; Essaghir, A.
10.1101/2022.12.16.520742 — bioinformatics — Posted on 2022-12-19
1515 The use of a graph database is a complementary approach to a classical similarity search for identifying commercially available fragment merges
Wills, S.; Sanchez-Garcia, R.; Roughley, S. D.; Merritt, A.; Hubbard, R. E.; Dudgeon, T.; Davidson, J.; von Delft, F.; Deane, C. M.
10.1101/2022.12.15.520559 — bioinformatics — Posted on 2022-12-19
1517 Predicting transcription factor activity using prior biological information
Estabrook, J.; Yashar, W. M.; Holly, H. D.; Somers, J.; Nikolova, O.; Barbur, O.; Braun, T. P.; Demir, E.
10.1101/2022.12.16.520295 — bioinformatics — Posted on 2022-12-19
1518 Consistent typing of plasmids with the mge-cluster pipeline
Arredondo-Alonso, S.; Gladstone, R. A.; Pontinen, A. K.; Gama, J. A.; Schurch, A. C.; Lanza, V. F.; Johnsen, P. J.; Samuelsen, O.; Tonkin-Hill, G.; Corander, J.
10.1101/2022.12.16.520696 — bioinformatics — Posted on 2022-12-19
1519 SnapFISH: a computational pipeline to identify chromatin loops from multiplexed DNA FISH data
Lee, L.; Yu, H.; Jia, B. B.; Jussila, A.; Zhu, C.; Chen, J.; Xie, L.; Hafner, A.; Strambio-De-Castillia, C.; Boettiger, A.; Ren, B.; Li, Y.; Hu, M.
10.1101/2022.12.16.520793 — bioinformatics — Posted on 2022-12-19
1522 Drinkable, liquid in situ-forming and tough hydrogels for gastrointestinal therapeutics
Liu, G. W.; Pickett, M. J.; Kuosmanen, J. L. P.; Ishida, K.; Madani, W. A. M.; White, G. N.; Jenkins, J.; Feig, V. R.; Jimenez, M.; Lopes, A.; Morimoto, J.; Fitzgerald, N.; Cheah, J. H.; Soule, C. K.; Fabian, N.; Hayward, A.; Langer, R. S.; Traverso, G.
10.1101/2022.12.15.520584 — bioengineering — Posted on 2022-12-19
1525 Aberrant miR-29 is a predictive feature of severe phenotypes in pediatric Crohn's disease
Shumway, A. J.; Shanahan, M. T.; Hollville, E.; Chen, K. A.; Beasley, C.; Villanueva, J. W.; Albert, S.; Lian, G.; Cure, M. R.; Schaner, M.; Zhu, L.-C.; Bantumilli, S.; Deshmukh, M.; Furey, T.; Sheikh, S.; Sethupathy, P.
10.1101/2022.12.16.520635 — genomics — Posted on 2022-12-19
1527 Preventing multiple resistance above all: new insights for managing fungal adaptation
Ballu, A.; Ugazio, C.; Duplaix, C.; Noly, A.; Wullschleger, J.; Torriani, S. F. F.; Deredec, A.; Carpentier, F.; Walker, A.-S.
10.1101/2022.12.17.520869 — evolutionary biology — Posted on 2022-12-19
1531 Abundant deep ocean heterotrophic bacteria are culturable
Sanz-Saez, I.; Sanchez, P.; Salazar, G.; Sunagawa, S.; de Vargas, C.; Bowler, C.; Sullivan, M. B.; Wincker, P.; Karsenti, E.; Pedros-Alio, C.; Agusti, S. R.; Gojobori, T.; Duarte, C. M.; Gasol, J. M.; Sanchez, O.; Acinas, S. G.
10.1101/2022.12.16.520132 — ecology — Posted on 2022-12-19
1532 30x30 biodiversity gains rely on national coordination
Eckert, I.; Brown, A.; Caron, D.; Riva, F.; Pollock, L. J.
10.1101/2022.12.16.520787 — ecology — Posted on 2022-12-19
1536 Development of a 3D bioprinted airway smooth muscle model for manipulating structure and measuring contraction
Osagie, J. O.; Syeda, S. S.; Turner-Brannen, E.; Guimond, M.; Parrenas, L. C.; Haroon, A.; Imasuen, P.; West, A. R.
10.1101/2022.12.15.520464 — physiology — Posted on 2022-12-19
1539 Ot2Rec: A Semi-Automatic, Extensible, Multi-Software Tomographic Reconstruction Workflow
Yee, N. B.- y.; Ho, E. M. L.; Tun, W.; Smith, J. L. R.; Dumoux, M.; Grange, M.; Darrow, M. C.; Basham, M.
10.1101/2022.12.15.520632 — bioinformatics — Posted on 2022-12-19
1545 Okapi-EM - a napari plugin for processing and analysing cryogenic serial FIB/SEM images
Perdigao, L. M. A.; Ho, E. M. L.; Cheng, Z. C.; Yee, N. B.- y.; Glen, T.; Wu, L.; Grange, M.; Dumoux, M.; Basham, M.; Darrow, M. C.
10.1101/2022.12.15.520541 — bioinformatics — Posted on 2022-12-19
1549 A pan-cnidarian microRNA is an ancient biogenesis regulator of stinging cells
Fridrich, A.; Salinas-Saavedra, M.; Kozlovski, I.; Surm, J. M.; Chrysostomou, E.; Tripathi, A. M.; Frank, U.; Moran, Y.
10.1101/2022.12.15.520629 — evolutionary biology — Posted on 2022-12-19
1553 Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology
Chauhan, N. R.; Kundu, S.; Bal, R.; Chattopadhyay, D.; Mehto, S.; Sahu, R.; Yadav, R.; Krishna, S.; Jena, K. K.; Satapathy, S.; Murmu, K. C.; Singh, B.; Das, S. K.; Jena, S.; Harshan, K. H.; Syed, G. H.; Prasad, P.; Chauhan, S.
10.1101/2022.12.17.520843 — immunology — Posted on 2022-12-19
1556 A monkeypox mRNA-lipid nanoparticle vaccine targeting virus binding, entry, and transmission drives protection against lethal orthopoxviral challenge
Freyn, A. W.; Atyeo, C.; Earl, P. L.; Americo, J. L.; Chuang, G.-Y.; Natarajan, H.; Frey, T. R.; Gall, J.; Moliva, J. I.; Hunegnaw, R.; Asthagiri Arunkumar, G.; Ogega, C.; Nasir, A.; Bennett, H.; Johnson, J.; Durney, M. A.; Stewart-Jones, G.; Hooper, J. W.; Colpitts, T.; Alter, G.; Sullivan, N. J.; Carfi, A.; Moss, B.
10.1101/2022.12.17.520886 — immunology — Posted on 2022-12-19
1557 High-Throughput Discovery and Characterization of Viral Transcriptional Effectors in Human Cells
Ludwig, C. H.; Thurm, A. R.; Morgens, D. W.; Yang, K. J.; Tycko, J.; Bassik, M. C.; Glaunsinger, B. A.; Bintu, L.
10.1101/2022.12.16.520835 — systems biology — Posted on 2022-12-19
1558 A versatile and interoperable computational framework for the analysis and modeling of COVID-19 disease mechanisms
Niarakis, A.; Ostaszewski, M.; Mazein, A.; Kuperstein, I.; Gillespie, M. E.; Kutmon, M.; Funahashi, A.; Acencio, M. L.; Hemedan, A.; Aichem, M.; Klein, K.; Czauderna, T.; Burtscher, F.; Yamada, T. G.; Hiki, Y.; Hiroi, N. F.; Hu, F.; Pham, N.; Ehrhart, F.; Willighagen, E. L.; Valdeolivas, A.; Dugourd, A.; Messina, F.; Esteban-Medina, M.; Pena-Chilet, M.; Rian, K.; Soliman, S.; Aghamiri, S. S.; Puniya, B. L.; Naldi, A.; Helikar, T.; Singh, V.; Farinas Fernandez, M.; Bermudez, V.; Tsirvouli, E.; Montagud, A.; Noel, V.; Ponce de Leon, M.; Maier, D.; Bauch, A.; Gyori, B. M.; Bachman, J. A.; Luna, A
10.1101/2022.12.17.520865 — systems biology — Posted on 2022-12-19
1561 A Novel Mouse Model of Chronic Primary Pain Conditions that Integrates Clinically Relevant Genetic and Environmental Factors
Wang, Y.; Kim, S. H.; Klein, M. E.; Chen, J.; Gu, E.; Smith, S. B.; Bortsov, A.; Slade, G. D.; Zhang, X.; Nackley, A. G.
10.1101/2022.12.18.520949 — neuroscience — Posted on 2022-12-19
1562 SNARE protein tomosyn regulates dense core vesicle composition but not exocytosis in mammalian neurons
Subkhangulova, A.; Gonzalez-Lozano, M. A.; Groffen, A. J. A.; van Weering, J. R. T.; Smit, A. B.; Toonen, R. F.; Verhage, M.
10.1101/2022.12.18.520925 — neuroscience — Posted on 2022-12-19
1567 Super-resolution STED imaging in the inner and outer whole-mount mouse retina
Kremers, L.; Sarieva, K.; Hoffmann, F.; Ueffing, M.; Euler, T.; Nikic-Spiegel, I.; Schubert, T.
10.1101/2022.12.18.520926 — neuroscience — Posted on 2022-12-19
1568 New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders
Pol Cros, M.; Mir-Pedrol, J.; Toloza, L.; Knoedlseder, N.; Maroutti, J.; Guell, M.; Fabrega, M. J.
10.1101/2022.12.15.520547 — immunology — Posted on 2022-12-19
1570 The nanomechanical fingerprint of colorectal-derived peritoneal metastasis
Lorenc, E.; Varinelli, L.; Chighizola, M.; Brich, S.; Pisati, F.; Guaglio, M.; Baratti, D.; Deraco, M.; Gariboldi, M.; Podesta, A.
10.1101/2022.08.17.504271 — biophysics — Posted on 2022-12-19
1573 A self-blinking DNA probe for 3D superresolution imaging of native chromatin
ZHENG, Y.; Ye, S.; Li, S.; Liu, C.; Luo, S.; Xia, R.; Chen, Y.; Li, Y.; Zhu, Z.; Huang, L.; Deng, S.; Yuen, K. W. Y.; Chen, P.; Zhang, Y.; Ji, W.; Luo, R.; Li, G.; Yang, D.
10.1101/2022.06.22.497271 — cell biology — Posted on 2022-12-19
1575 Establishment of a novel set of vectors for transformation of the dinoflagellate Amphidinium carterae
Nimmo, I.; Geisler, K.; Barbrook, A. C.; Kleiner, F. H.; Scarampi, A.; Kosmützky, D.; Nisbet, E.; Howe, C.
10.1101/2022.12.15.520308 — plant biology — Posted on 2022-12-19
1576 Organ-Founder Stem Cells Mediate Post-Embryonic Neuromast Formation In Medaka
Gross, K.; Raif, T.; Seleit, A.; Onistschenko, J.; Krämer, I.; Centanin, L.
10.1101/2022.12.16.520711 — developmental biology — Posted on 2022-12-19
1578 Brain-based predictions of psychiatric illness-linked behaviors across the sexes
Dhamala, E.; Ooi, L. Q. R.; Chen, J.; Ricard, J. A.; Berkeley, E.; Chopra, S.; Qu, Y.; Lawhead, C.; Yeo, B. T. T.; Holmes, A.
10.1101/2022.12.18.520947 — neuroscience — Posted on 2022-12-19
1579 Brain-wide associations between white matter and agehighlight the role of fornix microstructure in brain age
Korbmacher, M.; de Lange, A. M.; van der Meer, D.; Beck, D.; Eikefjord, E. N.; Lundervold, A.; Andreassen, O.; Westlye, L. T.; Maximov, I. I.
10.1101/2022.09.29.510029 — neuroscience — Posted on 2022-12-19
1583 Whole Organism Profiling of the Timp Gene Family
Peeney, D.; Fan, Y.; Gurung, S.; Lazaroff, C.; Ratnayake, S.; Warner, A.; Karim, B.; Meerzaman, D.; Stetler-Stevenson, W. G.
10.1101/2021.10.15.464572 — cell biology — Posted on 2022-12-18
1584 Associations of psychiatric disease and aging on FKBP5 expression converge on cortical supragranular neurons
Matosin, N.; Arloth, J.; Czamara, D.; Edmond, K. Z.; Maitra, M.; Froehlich, A. S.; Martinelli, S.; Kaul, D.; Bartlett, R.; Curry, A. R.; Gassen, N.; Hafner, K.; Mueller, N.; Worf, K.; Rehawi, G.; Nagy, C.; Halldorsdottir, T.; Cruceanu, C.; Gagliardi, M.; Gerstner, N.; Koedel, M.; Murek, V.; Ziller, M. J.; Scarr, E.; Tao, R.; Jaffe, A. E.; Arzberger, T.; Falkai, P.; Kleinmann, J.; Weinberger, D.; Mechawar, N.; Schmitt, A.; Dean, B.; Turecki, G.; Hyde, T. M.; Binder, E.
10.1101/2021.01.27.428487 — neuroscience — Posted on 2022-12-18
1588 A microbial community growth model for dynamic phenotype predictions
Freiburger, A. P.; Dewey, J. A.; Foflonker, F.; Babnigg, G.; Antonopoulos, D. A.; Henry, C. S.
10.1101/2022.12.15.520667 — systems biology — Posted on 2022-12-18
1589 Interleukin 31 receptor alpha induces airway hyperresponsiveness in asthma
Akkenepally, s.; Yombo, D. J.; Yerubandi, S.; Geereddy, B. R.; McCormack, F. X.; Madala, S. K.
10.1101/2022.12.15.520615 — pathology — Posted on 2022-12-18
1590 STING-dependent cytosolic DNA sensing pathway drives the progression to leukemia in TET2-mutated HSPCs
Xie, J.; Sheng, M.; Rong, S.; Wang, C.; Wu, W.; Huang, J.; Sun, Y.; Chen, P.; Wu, Y.; Wang, Y.; Wang, L.; Zhou, B.; Huang, X.; Walsh, C.; Bohlander, S.; Huang, J.; Wang, X.; Gao, H.; Zhou, D.; Shi, Y.; Xu, G.
10.1101/2022.12.17.520899 — cancer biology — Posted on 2022-12-18
1592 Poly(2-oxazoline)-based polyplexes as a PEG-free plasmid DNA delivery platform
Yamaleyeva, D.; Makita, N.; Hwang, D.; Haney, M.; Jordan, R.; Kabanov, A. V.
10.1101/2022.12.18.518592 — bioengineering — Posted on 2022-12-18
1593 North and East African mitochondrial genetic variation needs further characterization towards precision medicine
Fähnrich, A.; Stephan, I.; Hirose, M.; Haarich, F.; Awadelkareem, M. A.; Ibrahim, S.; Busch, H.; Wohlers, I.
10.1101/2021.12.10.472079 — genetics — Posted on 2022-12-18
1597 The first fossil replete ant worker establishes living food storage in the Eocene
Sawh, I.; Bae, E.; Camilo, L.; Lanan, M.; Lucky, A.; Menezes, H. M.; Fiorentino, G.; Sosiak, C.; Khadempour, L.; Barden, P.
10.1101/2022.12.15.520604 — evolutionary biology — Posted on 2022-12-18
1598 On the reproductive mechanisms of protocells
Kanaparthi, D.; Lampe, M.; Krohn, J. H.; Hildebrand, F.; Boesen, T.; Klingl, A.; Phapale, P.; Lueders, T.
10.1101/2021.11.25.470039 — evolutionary biology — Posted on 2022-12-18
1602 Activation of the P2RX7/IL-18 pathway in immune cells inhibits lung fibrosis
Janho dit Hreich, S.; Juhel, T.; Leroy, S.; Brau, F.; hofman, v.; hofman, p.; Vouret-Craviari, V.
10.1101/2022.12.15.520590 — immunology — Posted on 2022-12-18
1603 Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons
Beatriz, M.; Rodrigues, R.; Vilaca, R.; Egas, C.; Pinheiro, P.; Daley, G. Q.; Schlaeger, T. M.; Rego, A. C.; Lopes, C.
10.1101/2022.12.18.520919 — neuroscience — Posted on 2022-12-18
1605 A plant virus causes symptoms through the deployment of a host-mimicking protein domain to attract the insect vector
Gao, M.; Aguilar, E.; Garnelo Gomez, B.; Medina-Puche, L.; Fan, P.; Ontiveros, I.; Pan, S.; Tan, H.; von Roepenack-Lahaye, E.; Chen, N.; Wang, X.-W.; Baulcombe, D. C.; Bejarano, E. R.; Diaz-Pendon, J. A.; Furutani, M.; Morita, M. T.; Lozano-Duran, R.
10.1101/2022.12.16.520777 — plant biology — Posted on 2022-12-18
1606 Dynamic interplay between target search and recognition for the Cascade surveillance complex of type I-E CRISPR-Cas systems
Aldag, P.; Rutkauskas, M.; Madariaga-Marcos, J.; Songailiene, I.; Sinkunas, T.; Kemmerich, F. E.; Kauert, D. J.; Siksnys, V.; Seidel, R.
10.1101/2022.12.18.520913 — biophysics — Posted on 2022-12-18
1608 State-dependent photocrosslinking unveiled the role of intersubunit interfaces on Ca2+ activating mechanisms of the BK channel
Gonzalez-Hernandez, A. J.; Rivero-Perez, B.; Bartolome-Martin, D.; Alvarez de la Rosa, D.; Plested, A. J. R.; Giraldez, T.
10.1101/2022.12.15.520511 — biophysics — Posted on 2022-12-18
1610 The Radiogenomic and Spatiogenomic Landscapes of Glioblastoma, and Their Relationship to Oncogenic Drivers
Fathi Kazerooni, A.; Akbari, H.; Hu, X.; Bommineni, V.; Grigoriadis, D.; Toorens, E.; Sako, C.; Mamourian, E.; Ballinger, D.; Sussman, R.; Singh, A.; Verginadis, I. I.; Dahmane, N.; Koumenis, C.; Binder, Z. A.; Bagley, S. J.; Mohan, S.; Hatzigeorgiou, A.; O'Rourke, D. M.; Ganguly, T.; De, S.; Bakas, S.; Nasrallah, M. P.; Davatzikos, C.
10.1101/2022.12.15.517767 — bioengineering — Posted on 2022-12-18
1611 De novo assembly and annotation of the Patagonian toothfish (Dissostichus eleginoides) genome
Ryder, D.; Stone, D. M.; Minardi, D.; Riley, A.; Avant, J.; Cross, L. J.; Soeffker, M.; Davidson, D.; Newman, A.; Thomson, P.; Darby, C.; van Aerle, R.
10.1101/2022.12.15.520537 — genomics — Posted on 2022-12-18
1612 Dissecting the Human Leptomeninges at single-cell resolution
Kearns, N.; Iatrou, A.; Flood, D.; Tissera, S. D.; Mullaney, Z. M.; Xu, J.; Gaiteri, C.; Bennett, D. A.; Wang, Y.
10.1101/2022.12.15.520647 — genomics — Posted on 2022-12-18
1613 Logging alters tropical forest structure, while conversion reduces biodiversity and functioning
Marsh, C. J.; Turner, E. C.; Blonder, B.; Bongalov, B.; Both, S.; Cruz, R. S.; Elias, D. M. O.; Hemprich-Bennett, D.; Jotan, P.; Kemp, V.; Kritzler, U. H.; Milne, S.; Milodowski, D. T.; Mitchell, S. L.; Montoya Pillco, M.; Nunes, M. H.; Riutta, T.; Robinson, S. J. B.; Slade, E. M.; Bernard, H.; Burslem, D. F. R. P.; Chung, A. Y. C.; Clare, E. L.; Coomes, D. A.; Davies, Z. G.; Edwards, D. P.; Johnson, D.; Kratina, P.; Malhi, Y.; Majalap, N.; Nilus, R.; Ostle, N. J.; Rossiter, S. J.; Struebig, M. J.; Williams, M.; Ewers, R. M.; Lewis, O. T.; Reynolds, G.; Teh, Y. A.; Hector, A.
10.1101/2022.12.15.520573 — ecology — Posted on 2022-12-18
1614 Novel uAUG creating variants in the 5UTR of ENG causing Hereditary Hemorrhagic Telangiectasia
Soukarieh, O.; Tillet, E.; Proust, C.; Dupont, C.; Jaspard-Vinassa, B.; Soubrier, F.; Goyenvalle, A.; Eyries, M.; Tregouet, D.-A.
10.1101/2022.12.18.520932 — molecular biology — Posted on 2022-12-18
1615 Ongoing emergence of M1UK lineage among invasive group A streptococcus isolates in 2020 and use of allele-specific PCR
Zhi, X.; Li, H. K.; Li, H.; Loboda, Z.; Charles, S.; Vieira, A.; Huse, K. K.; Jauneikaite, E.; Coelho, J.; Lamagni, T.; Sriskandan, S.
10.1101/2022.12.18.520871 — microbiology — Posted on 2022-12-18
1616 The episodic resurgence of highly pathogenic avian influenza H5 virus
Xie, R.; Edwards, K. M.; Wille, M.; Wei, X.; Wong, S.-S.; Zanin, M.; El-Shesheny, R.; Ducatez, M.; Poon, L. L. M.; Kayali, G.; Webby, R. J.; Dhanasekaran, V.
10.1101/2022.12.18.520670 — microbiology — Posted on 2022-12-18
1618 Functional mRNA delivery to hematopoietic stem and progenitor cells in vivo.
Alvarez, D.; Masse-Ranson, G.; Sedimbi, S. K.; Wisti, P.; Rodriguez, L.; Santana, J.; Manning, T.; Towner, T.; Geilich, B.; Mihai, C.; Mishra, A.; Gurumurthy, S.; Frederick, J.; von Andrian, U. H.; Hoggatt, J.; Moore, M. J.; Mora, J. R.
10.1101/2022.12.15.520650 — immunology — Posted on 2022-12-18
1623 Reductive Enzyme Cascades for Valorization of PET Deconstruction Products
Gopal, M. R.; Dickey, R. M.; Butler, N. D.; Talley, M. R.; Mohapatra, A.; Watson, M. P.; Chen, W.; Kunjapur, A. M.
10.1101/2022.12.16.520786 — synthetic biology — Posted on 2022-12-18
1627 An important role for triglyceride in regulating spermatogenesis
Chao, C. F.; Pesch, Y.-Y.; Yu, H.; Wang, C.; Aristizabal, M. J.; Huan, T.; Tanentzapf, G.; Rideout, E.
10.1101/2022.12.16.520841 — developmental biology — Posted on 2022-12-18
1628 PXN/Paxillin Phase Separation Promotes Focal Adhesion Assembly and Integrin Signaling
Wang, B.; Liang, P.; Wu, Y.; Zheng, S.; Zhang, J.; Yang, S.; Wang, J.; Ma, S.; Zhang, M.; Gu, Z.; Liu, Q.; Jiang, W.; Xing, Q.
10.1101/2022.12.17.520852 — cell biology — Posted on 2022-12-18
1629 A high-throughput COPD bronchosphere model for disease-relevant phenotypic compound screening
Beri, P.; Woo, Y. J.; Schierenbeck, K.; Chen, K.; Barnes, S. W.; Ross, O.; Krutil, D.; Quackenbush, D.; Fang, B.; Walker, J.; Barnes, W.; Toyama, E.
10.1101/2022.12.16.520302 — cell biology — Posted on 2022-12-18
1630 The phosphoinositide signature guides the final step of plant cytokinesis
Lebecq, A.; Fangain, A.; Gascon, E.; Golgy, C.; Belcram, K.; Pastuglia, M.; Bouchez, D.; Caillaud, M.-C.
10.1101/2022.12.18.520917 — cell biology — Posted on 2022-12-18
1631 Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis
Hewitt, R. J.; Puttur, F.; Gaboriau, D. C. A.; Fercoq, F.; Fresquet, M.; Traves, W. J.; Yates, L. L.; Walker, S. A.; Molyneaux, P. L.; Kemp, S. V.; Nicholson, A. G.; Rice, A.; Lennon, R.; Carlin, L. M.; Byrne, A. J.; Maher, T. M.; Lloyd, C. M.
10.1101/2022.12.16.520808 — cell biology — Posted on 2022-12-18
1633 WRNIP1 PREVENTS G4/R-LOOP-ASSOCIATED GENOMIC INSTABILITY
Valenzisi, P.; Marabitti, V.; Petrai, S.; Giardinelli, F. R.; Pichierri, P.; Franchitto, A.
10.1101/2022.12.17.520882 — cell biology — Posted on 2022-12-18
1636 SGC-CLK-1 (CAF-170) a chemical probe for the Cdc2-Like kinases CLK1, CLK2, and CLK4
Tiek, D.; Wells, C. I.; Schroder, M.; Song, X.; Ferrer, C. A.; Goenka, A.; Iglesia, R.; Lu, M.; Hu, B.; Kwarcinski, F.; Sintha, P.; de Silva, C.; Hossain, M. A.; Picado, A.; Zuercher, W.; Zutshi, R.; Knapp, S.; Riggins, R. B.; Cheng, S.; Drewry, D.
10.1101/2022.12.15.520623 — cancer biology — Posted on 2022-12-18
1637 Prediction of cancer treatment response from histopathology images through imputed transcriptomics
Hoang, D.-T.; Dinstag, G.; Hermida, L. C.; Ben-Zvi, D. S.; Elis, E.; Caley, K.; Sammut, S.-J.; Sinha, S.; Sinha, N.; Dampier, C. H.; Stossel, C.; Patil, T.; Rajan, A.; Lassoued, W.; Strauss, J.; Bailey, S.; Allen, C.; Redman, J.; Beker, T.; Jiang, P.; Golan, T.; Wilkinson, S.; Sowalsky, A. G.; Pine, S. R.; Caldas, C.; Gulley, J. L.; Aldape, K.; Aharonov, R.; Stone, E. A.; Ruppin, E.
10.1101/2022.06.07.495219 — cancer biology — Posted on 2022-12-18
1641 Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements
Wirthlin, M. E.; Schmid, T. A.; Elie, J. E.; Zhang, X.; Shvareva, V. A.; Rakuljic, A.; Ji, M. B.; Bhat, N. S.; Kaplow, I. M.; Schäffer, D. E.; Lawler, A. J.; Annaldasula, S.; Lim, B.; Azim, E.; Zoonomia Consortium, ; Meyer, W. K.; Yartsev, M. M.; Pfenning, A. R.
10.1101/2022.12.17.520895 — neuroscience — Posted on 2022-12-18
1642 Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Eyraud, E.; Maurat, E.; Sac-Epee, J.-M.; Henrot, P.; Zysman, M.; Esteves, P.; Trian, T.; Begueret, H.; Girodet, P.-O.; Thumerel, M.; Hustache-Castaing, R.; Marthan, R.; Levet, F.; Vallois, P.; Contin-Bordes, C.; Berger, P.; Dupin, I.
10.1101/2022.10.21.513138 — pathology — Posted on 2022-12-18
1644 Genetic diversity, population structure and parentage analysis of Brazilian grapevine hybrids after half a century of genetic breeding
de Oliveira, G. L.; Niederauer, G. F.; de Oliveira, F. A.; Rodrigues, C. S.; Hernandes, J. L.; de Souza, A. P.; Moura, M. F.
10.1101/2022.07.30.502144 — molecular biology — Posted on 2022-12-18
1645 Revealing the spacetime hierarchical whole-brain dynamics of auditory predictive coding
Bonetti, L.; Fernandez-Rubio, G.; Carlomagno, F.; Pantazis, D.; Vuust, P.; Kringelbach, M. L.
10.1101/2022.11.19.517195 — neuroscience — Posted on 2022-12-18
1648 Quantifying B-cell Clonal Diversity In Repertoire Data
Pelissier, A.; Luo, S.; Stratigopoulou, M.; Guikema, J.; Rodriguez Martinez, M.
10.1101/2022.12.12.520133 — bioinformatics — Posted on 2022-12-18
1649 Reliable energy-based antibody humanization and stabilization
Tennenhouse, A.; Khmelnitsky, L.; Khalaila, R.; Yeshaya, N.; Noronha, A.; Lindzen, M.; Makowski, E.; Zaretsky, I.; Fridmann Sirkis, Y.; Galon-Wolfenson, Y.; Tessier, P. M.; Abramson, J.; Yarden, Y.; Fass, D.; Fleishman, S. J.
10.1101/2022.08.14.503891 — bioengineering — Posted on 2022-12-18
1651 A second unveiling: haplotig masking of the eastern oyster genome improves population-level inference
Puritz, J. B.; Guo, X.; Hare, M. P.; He, Y.; Hillier, L.; Liu, M.; Lotterhos, K. E.; Minx, P.; Modak, T.; Proestou, D.; Rice, E. S.; Tomlison, C.; Warren, W. C.; Witkop, E.; Zhao, H.; Gomez-Chiarri, M.
10.1101/2022.08.29.505626 — genomics — Posted on 2022-12-17
1654 Improved humoral immunity and protection against influenza virus infection with a 3D porous biomaterial vaccine
Miwa, H.; Antao, O. Q.; Kelly-Scumpia, K. M.; Baghdasarian, S.; Mayer, D. P.; Shang, L.; Sanchez, G. M.; Archang, M. M.; Scumpia, P. O.; Weinstein, J. S.; Di Carlo, D.
10.1101/2022.12.16.520784 — bioengineering — Posted on 2022-12-17
1656 Heritability of de novo germline mutation reveals a contribution from paternal but not maternal genetic factors
Hwang, S.; Neville, M. D. C.; Genomics England Research Consortium, ; Day, F. R.; Scally, A.
10.1101/2022.12.17.520885 — genetics — Posted on 2022-12-17
1658 Earthworm and Soil Microbial Communities in Flower Strips
Bednar, Z.; Vaupel, A.; Blümel, S.; Herwig, N.; Hommel, B.; Haberlah-Korr, V.; Beule, L.
10.1101/2022.12.15.520680 — ecology — Posted on 2022-12-17
1659 Distinct myofibre domains of the human myotendinous junction revealed by single nucleus RNA-seq
Karlsen, A.; Yeung, C.-Y. C.; Schjerling, P.; Denz, L.; Hoegsbjerg, C.; Jakobsen, J. R.; Krogsgaard, M. R.; Koch, M.; Schiaffino, S.; Kjaer, M.; Mackey, A. L.
10.1101/2022.12.16.519020 — molecular biology — Posted on 2022-12-17
1660 Transcriptional and translational dynamics underlying heat shock response in the thermophilic Crenarchaeon Sulfolobus acidocaldarius
Baes, R.; Grünberger, F.; Pyr dit Ruys, S.; Couturier, M.; De Keulenaer, S.; Skevin, S.; Van Nieuwerburgh, F.; Vertommen, D.; Grohmann, D.; Ferreira-Cerca, S.; Peeters, E.
10.1101/2022.12.17.520879 — microbiology — Posted on 2022-12-17
1663 Evaluation of Mycobacterium Tuberculosis enrichment in metagenomic samples using ONT adaptive sequencing and amplicon sequencing for identification and variant calling
Su, J.; Lui, W. W.; Lee, Y.; Zheng, Z.; Siu, G. K.-H.; Ng, T. T.-L.; Zhang, T.; Lam, T. T.-Y.; Lao, H.-Y.; Yam, W.-C.; Tam, K. K.-G.; Leung, K. S.-S.; Lam, T.-W.; Leung, A. W.-S.; Luo, R.
10.1101/2022.12.17.520855 — bioinformatics — Posted on 2022-12-17
1664 Ultra-long-acting refillable nanofluidic implant confers full protection against SHIV infection in non-human primates
Pons-Faudoa, F. P.; Di Trani, N.; Capuani, S.; Campa-Carranza, J. N.; Nehete, B.; Sharma, S.; Shelton, K. A.; Bushman, L. R.; Abdelmawla, F.; Williams, M.; Roon, L.; Nerguizian, D.; Chua, C. Y. X.; Ittmann, M. M.; Nichols, J. E.; Kimata, J. T.; Anderson, P. L.; Nehete, P. N.; Arduino, R. C.; Grattoni, A.
10.1101/2022.12.15.520646 — bioengineering — Posted on 2022-12-17
1665 Targeted Kinase Degradation via the KLHDC2 Ubiquitin E3 Ligase
Kim, Y.; Seo, C.; Jeon, E.; You, I.; Hwang, K.; Kim, N.; Choi, H.-S.; Hinshaw, S. M.; Sim, T.; Gray, N.
10.1101/2022.12.17.520883 — biochemistry — Posted on 2022-12-17
1666 Identification of a Non-Canonical Ciliate Nuclear Genetic Code Where UAA and UAG Code for Different Amino Acids
McGowan, J.; Kilias, E. S.; Alacid, E.; Lipscombe, J.; Jenkins, B. H.; Gharbi, K.; Kaithakottil, G. G.; Macaulay, I. C.; McTaggart, S.; Warring, S. D.; Richards, T. A.; Hall, N.; Swarbreck, D.
10.1101/2022.12.16.520718 — genomics — Posted on 2022-12-17
1667 A chromosome-scale high-contiguity genome assembly of the threatened cheetah (Acinonyx jubatus)
Winter, S.; Meissner, R.; Greve, C.; Ben Hamadou, A.; Horin, P.; Prost, S.; Burger, P. A.
10.1101/2022.12.16.520814 — genomics — Posted on 2022-12-17
1671 Census of exposed aggregation-prone regions in proteomes
Falgarone, T.; Villain, E.; Richard, F.; Osmanli, Z.; KAJAVA, A. V.
10.1101/2022.12.16.520802 — molecular biology — Posted on 2022-12-17
1672 Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques
Jaeger, A. S.; Crooks, C. M.; Weiler, A. M.; Bliss, M. I.; Rybarczyk, S. L.; Richardon, A.; Einwalter, M.; Peterson, E.; Capuano, S.; Barkhymer, A.; Becker, J. T.; Greene, J. T.; Freedman, T. S.; Langlois, R. A.; Friedrich, T. C.; Aliota, M. T.
10.1101/2022.12.16.520792 — microbiology — Posted on 2022-12-17
1677 The ins and outs of membrane bending by intrinsically disordered proteins
Yuan, F.; Houser, J.; Sangani, A.; Wang, L.; Lafer, E.; Rangamani, P.; Stachowiak, J.
10.1101/2022.12.17.520884 — biophysics — Posted on 2022-12-17
1680 To make a short story long: simultaneous short and long RNA profiling on Nanopore devices
Mackenzie, M.; Tigert, S.; Lovato, D.; Mir, H.; Zahedi, K.; Barone, S. L.; Brooks, M.; Soleimani, M.; Argyropoulos, C.
10.1101/2022.12.16.520507 — molecular biology — Posted on 2022-12-17
1682 Ythdf2 regulates cardiac remodeling through its m6A-mRNA target transcripts
Kmietczyk, V.; Oelschlaeger, J.; Varma, E.; Hartl, S.; Konstandin, M.; Marx, A.; Gupta, P.; Loewenthal, Z.; Kamuf-Schenk, V.; Juergensen, L.; Stroh, C.; Gorska, A.; Jakobi, T.; Frey, N.; Voelkers, M.
10.1101/2022.12.16.520765 — molecular biology — Posted on 2022-12-17
1683 Nodavirus RNA Replication Crown Architecture Reveals Proto-Crown Precursor and Viral Protein A Conformational Switching
Zhan, H.; Unchwaniwala, N.; Rebolledo-Viveros, A.; Pennington, J.; Horswill, M.; Broadberry, R.; Myers, J.; den Boon, J. A.; Grant, T.; Ahlquist, P.
10.1101/2022.12.16.520638 — microbiology — Posted on 2022-12-17
1684 A scalable and robust system for Audience EEG recordings
Michalareas, G.; Rudwan, I. M. A.; Lehr, C.; Gessini, P.; Tavano, A.; Grabenhorst, M.
10.1101/2022.12.16.520764 — neuroscience — Posted on 2022-12-17
1685 Neuron secreted chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different neuronal remodeling paradigms
Perron, C.; Carme, P.; Llobet Rosell, A.; Minnaert, E.; Ruiz Demoulin, S.; Szczkowski, H.; Neukomm, L. J.; Dura, J.-M.; Boulanger, A.
10.1101/2022.12.16.520775 — neuroscience — Posted on 2022-12-17
1687 Motion Impact Score for Detecting Spurious Brain-Behavior Associations
Kay, B. P.; Montez, D. F.; Marek, S.; Tervo-Clemmens, B.; Siegel, J. S.; Adeyemo, B.; Laumann, T. O.; Metoki, A.; Chauvin, R. J.; Van, A. N.; Krimmel, S. R.; Miller, R.; Newbold, D. J.; Zheng, A.; Seider, N. A.; Scheidter, K. M.; Monk, J.; Feczko, E. J.; Randolph, A.; Miranda Dominguez, O.; Moore, L. A.; Perrone, A. J.; Conan, G. M.; Earl, E. A.; Malone, S. M.; Cordova, M.; Doyle, O.; Lynch, B. J.; Wilgenbusch, J. C.; Pengo, T.; Graham, A. M.; Roland, J. L.; Gordon, E. M.; Snyder, A. Z.; Barch, D.; Fair, D. A.; Dosenbach, N. U.
10.1101/2022.12.16.520797 — neuroscience — Posted on 2022-12-17
1692 High Throughput Detection of Capillary Stalling Events with Bessel Beam Two-Photon Microscopy
Giblin, J.; Kura, S.; Ugarte Nunuez, J. L.; Zhang, J.; Kureli, G.; Jiang, J.; Boas, D. A.; Chen, I. A.
10.1101/2022.12.16.520779 — neuroscience — Posted on 2022-12-17
1695 Cytidine deaminase regulates mitochondrial biogenesis in pancreatic cancer cells
Frances, A.; Lumeau, A.; Stuani, L.; Gayral, M.; Salland, E.; Bery, N.; Pagan, D.; Hanoun, N.; Torrisani, J.; Lemarie, A.; Portais, J.-C.; Buscail, L.; Dusetti, N.; Sarry, J.-E.; Cordelier, P.
10.1101/2022.12.15.520429 — cancer biology — Posted on 2022-12-17
1696 Convergent Evolution and B-Cell Recirculation in Germinal Centers in a Human Lymph Node
Pelissier, A.; Stratigopoulou, M.; Donner, N.; Dimitriadis, E.; Bende, R. J.; Guikema, J. E.; Martinez, M. R.; van Noesel, C. J. M.
10.1101/2022.11.09.463832 — evolutionary biology — Posted on 2022-12-17
1697 Local angiogenic interplay of Vegfc/d and Vegfa drives fenestrated capillary network formation in the choroid plexuses and circumventricular organs
Parab, S.; Card, O. A.; Chen, Q.; Buck, L. D.; Quick, R. E.; Horrigan, W. F.; Levkowitz, G.; Vanhollebeke, B.; Matsuoka, R. L.
10.1101/2022.12.08.519692 — developmental biology — Posted on 2022-12-17
1699 Task-specific modulation of corticospinal neuron activity during skilled motor learning
Serradj, N.; Marino, F.; Moreno-Lopez, Y.; Bernstein, A.; Agger, S.; Soliman, M.; Sloan, A. M.; Hollis, E. R.
10.1101/2021.03.22.436415 — neuroscience — Posted on 2022-12-17
1701 Intercellular Mitochondrial Transfer as a Rescue Mechanism in Response to Protein Import Failure
Needs, H. I.; Pereira, G. C.; Glover, E.; Witt, A.; Hubner, W.; Dodding, M.; Henley, J.; Collinson, I.
10.1101/2022.11.30.518494 — cell biology — Posted on 2022-12-17
1705 Ixodes ricinus tick bacteriome alterations based on a climatically representative survey in Hungary
Toth, A. G.; Farkas, R.; Papp, M.; Kilim, O.; Haeun, Y.; Makrai, L.; Maroti, G.; Gyurkovszky, M.; Kriko, E.; Solymosi, N.
10.1101/2022.10.15.512391 — genomics — Posted on 2022-12-17
1706 How woodcocks produce the most brilliant white plumage patches among the birds
Dunning, J.; Patil, A.; Bond, A.; D'Alba, L.; Debruyn, G.; Dhinojwala, A.; Shawkey, M.; Jenni, L.
10.1101/2022.12.09.519795 — ecology — Posted on 2022-12-17
1707 Protein-coding evolution does not explain divergence in petal anthocyanin pigmentation between two monkeyflower species
Orr, W. E.; Kim, J. Y.; Raj, T.; Hom, E. K.; Person, A. E.; Vonada, A.; Stratton, J. A.; Cooley, A. M.
10.1101/2022.12.11.519905 — molecular biology — Posted on 2022-12-17
1708 Comparative genomics and transcriptomic response to root exudates of six rice root-associated Burkholderia sensu lato species
Wallner, A.; Klonowska, A.; Guigard, L.; King, E.; Rimbault, I.; Ngonkeu, E. L.; Nguyen, P. V.; Bena, G.; Moulin, L.
10.1101/2022.10.04.510755 — microbiology — Posted on 2022-12-17
1716 Role of the EGR2 promoter antisense RNA in modulating chromatin accessibility and spatial genome organization
Moreno, M.-M.; Karambizi, D.; Hwang, H.; Fregoso, K.; Chen, J.-S.; Fajardo, J. E.; Fiser, A.; Tapinos, N.
10.1101/2022.05.02.490330 — genomics — Posted on 2022-12-17
1718 Amplification is the Primary Mode of Gene-by-Sex Interaction in Complex Human Traits
Zhu, C.; Ming, M. J.; Cole, J. M.; Edge, M. D.; Kirkpatrick, M.; Harpak, A.
10.1101/2022.05.06.490973 — genomics — Posted on 2022-12-17
1722 Ex vivo midgut cultures of Aedes aegypti are efficiently infected by mosquito-borne alpha- and flaviviruses
Rosales Rosas, A. L.; Wang, L.; Goossens, S.; Cuvry, A.; Li, L.-H.; Santos-Ferreira, N.; Soto, A.; Dallmeier, K.; Rocha-Pereira, J.; Delang, L.
10.1101/2022.08.09.503233 — molecular biology — Posted on 2022-12-17
1724 Safety Recommendations for Temporal Interference Stimulation in the Brain
Cassara, A. M.; Newton, T. H.; Zhuang, K.; Regel, S.; Achermann, P.; Kuster, N.; Neufeld, E.
10.1101/2022.12.15.520077 — neuroscience — Posted on 2022-12-17
1726 Time as a supervisor: temporal regularity and auditory object learning
DiTullio, R. W.; Parthiban, C.; Piasini, E.; Chaudhari, P.; Balasubramanian, V.; Cohen, Y. E.
10.1101/2022.11.10.515986 — neuroscience — Posted on 2022-12-17
1728 Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain
Hobson, B.; Stanley, A.; De Los Santos, M.; Culbertson, B.; Mosharov, E.; Sims, P.; Sulzer, D.
10.1101/2022.12.14.520294 — neuroscience — Posted on 2022-12-17
1729 Neural correlates of memory in an immersive spatiotemporal context
Dougherty, M. R.; Chang, W.; Rudoler, J. H.; Katerman, B. S.; Halpern, D.; Bruska, J. P.; Diamond, N.; Kahana, M. J.
10.1101/2022.11.30.518606 — neuroscience — Posted on 2022-12-17
1730 Small transcriptional differences lead to distinct NF-κB dynamics in quasi-identical cells
Kizilirmak, C.; Monteleone, E.; Garcia-Manteiga, J. M.; Brambilla, F.; Agresti, A.; Bianchi, M. E.; Zambrano, S.
10.1101/2021.12.07.471485 — systems biology — Posted on 2022-12-17
1737 Direct neural perturbations reveal a dynamical mechanism for robust computation
O'Shea, D. J.; Duncker, L.; Goo, W.; Sun, X.; Vyas, S.; Trautmann, E. M.; Diester, I.; Ramakrishnan, C.; Deisseroth, K.; Sahani, M.; Shenoy, K. V.
10.1101/2022.12.16.520768 — neuroscience — Posted on 2022-12-16
1738 The protooncogene Ski regulates the neuron-glia switch during development of the mammalian cerebral cortex
Grison, A.; Karimaddini, Z.; Breda, J.; Mukhtar, T.; Boareto, M.; Eschbach, K.; Beisel, C.; Iber, D.; van Nimwegen, E.; Taylor, V.; Atanasoski, S.
10.1101/2022.12.16.520470 — systems biology — Posted on 2022-12-16
1739 Morphogenesis of bullet-shaped rabies virus particles requires a functional interplay between the viral matrix protein and ESCRT-I component TSG101
Itakura, Y.; Tabata, K.; Saito, T.; Intaruck, K.; Kawaguchi, N.; Kishimoto, M.; Torii, S.; Kobayashi, S.; Ito, N.; Harada, M.; Inoue, S.; Maeda, K.; Takada, A.; Hall, W. W.; Orba, Y.; Sawa, H.; Sasaki, M.
10.1101/2022.12.16.520694 — microbiology — Posted on 2022-12-16
1740 A pathogen effector FOLD diversified in symbiotic fungi
Teulet, A.; Quan, C.; Evangelisti, E.; Wanke, A.; Yang, W.; Schornack, S.
10.1101/2022.12.16.520752 — microbiology — Posted on 2022-12-16
1743 The compact CasPi (Cas12l) bracelet "provides" a unique structural platform for DNA manipulation
Sun, A.; Li, C.; Chen, Z.; Zhang, S.; Li, D.; Yang, Y.; Li, L.-Q.; Zhao, Y.; Wang, K.; Li, Z.; Liu, J.; Liu, S.; Wang, J.; Liu, J.-J. G.
10.1101/2022.12.16.519550 — biophysics — Posted on 2022-12-16
1747 Transposable elements as tissue-specific enhancers in cancers of endodermal lineage
Karttunen, K.; Patel, D.; Xia, J.; Fei, L.; Palin, K.; Aaltonen, L.; Sahu, B.
10.1101/2022.12.16.520732 — genomics — Posted on 2022-12-16
1748 ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis and meiosis
Guo, C.; Xiao, Y.; Gu, J.; Hu, Z.; Zheng, J.; Hua, R.; Hai, Z.; Su, J.; Zhang, J.; Yeung, W. S. B.; Wang, T.
10.1101/2022.12.16.520702 — developmental biology — Posted on 2022-12-16
1749 A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin
Gu, W.; Huang, X.; Singh, P. N. P.; Lan, Y.; Gomez-Salinero, J. M.; Rafii, S.; Verzi, M.; Shivdasani, R.; Zhou, Q.
10.1101/2022.12.15.520587 — developmental biology — Posted on 2022-12-16
1752 Predictability of the community-function landscape in wine yeast ecosystems
Ruiz, J.; de Celis, M.; Diaz-Colunga, J.; Vila, J. C. C.; Benitez-Dominguez, B.; VICENTE, J.; Santos, A.; Sanchez, A.; Belda, I.
10.1101/2022.12.15.520418 — microbiology — Posted on 2022-12-16
1756 Parallel motion vision pathways in the brain of a tropical bee
Honkanen, A.; Hensgen, R.; Kannan, K.; Adden, A.; Warrant, E.; Wcislo, W.; Heinze, S.
10.1101/2022.12.16.520712 — neuroscience — Posted on 2022-12-16
1758 Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms
Ariey-Bonnet, J.; Berges, R.; Montero, M.-P.; Mouysset, B.; Piris, P.; Muller, K.; Pinna, G.; Failes, T. W.; Arndt, G. M.; Baeza-Kallee, N.; Colin, C.; Chinot, O.; Braguer, D.; Morelli, X.; ANDRE, N.; Carre, M.; Tabouret, E.; Figarella-Branger, D.; Le Grand, M.; Pasquier, E.
10.1101/2022.12.14.520491 — pharmacology and toxicology — Posted on 2022-12-16
1762 Cholesterol and ceramide facilitate SARS-CoV-2 Spike protein-mediated membrane fusion
Niort, K.; Dancourt, J.; Boedec, E.; Al Amir Dache, Z.; Lavieu, G.; Tareste, D.
10.1101/2022.12.16.520599 — biophysics — Posted on 2022-12-16
1767 Steric Communication between Dynamic Components on DNA nanodevices
Wang, Y.; Sensale, S.; Pedrozo, M.; Huang, C. M.; Poirier, M. G.; Arya, G.; Castro, C. E.
10.1101/2022.12.15.520588 — bioengineering — Posted on 2022-12-16
1770 AB668, a novel highly selective protein kinase CK2 inhibitor with a distinct anti-tumor mechanism as compared to CX-4945 and SGC-CK2-1
Bancet, A.; Frem, R.; Jeanneret, F.; Mularoni, A.; Bazelle, P.; Roelants, C.; Delcros, J.-G.; Guichou, J.-F.; Pillet, C.; Coste, I.; Renno, T.; Battail, C.; Cochet, C.; Lomberget, T.; Filhol, O.; Krimm, I.
10.1101/2022.12.16.520736 — biochemistry — Posted on 2022-12-16
1771 Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by epitope selection
Akiba, H.; Fujita, J.; Ise, T.; Nishiyama, K.; Miyata, T.; Kato, T.; Namba, K.; Ohno, H.; Kamada, H.; Nagata, S.; Tsumoto, K.
10.1101/2022.12.15.520217 — biochemistry — Posted on 2022-12-16
1772 Non-coding autoimmune risk variant accelerates T peripheral helper cell development via ICOS
Nigrovic, P. A.; Kim, T.; Martinez-Bonet, M.; Wang, Q.; Hackert, N.; Sparks, J. A.; Baglaenko, Y.; Koh, B.-H.; Darbousset, R.; Laza-Briviesca, R.; Chen, X.; Gutierrez-Arcelus, M.; Westra, H.-J.; Weirauch, M. T.; Raychaudhuri, S.; Rao, D. A.
10.1101/2022.12.16.520733 — genetics — Posted on 2022-12-16
1774 Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants.
Munoz Alia, M. A.; Nace, R. A.; Balakrishnan, B.; Zhang, L.; Packiriswamy, N.; Singh, G.; Warang, P.; Mena, I.; Narjari, R.; Vandergaast, R.; Garcia-Sastre, A.; Schotsaert, M.; Russell, S. J.
10.1101/2022.12.16.520799 — microbiology — Posted on 2022-12-16
1779 Quantifying the deformability of malaria-infected red blood cells using deep learning trained on synthetic cells
Rademaker, D. T.; Koopmans, J. J.; Thyen, G. M. S. M.; Piruska, A.; Huck, W. T. S.; Vriend, G.; 't Hoen, P. A. C.; Kooij, T. W. A.; Huynen, M. A.; Proellochs, N. I.
10.1101/2022.12.16.520724 — microbiology — Posted on 2022-12-16
1780 Host Immunity to Mycobacterium tuberculosis Infection is Similar in Simian Immunodeficiency Virus (SIV)-infected, Antiretroviral Therapy-treated and SIV-naïve Juvenile Macaques
Larson, E. C.; Ellis-Connell, A. L.; Rodgers, M.; Gubernat, A. K.; Gleim, J. L.; Moriarty, R. V.; Balgeman, A. J.; Menezes, Y. K.; Ameel, C.; Filmore, D. J.; Pergalske, S. M.; Juno, J. A.; Maiello, P.; White, A. G.; Borish, H. J.; Godfrey, D. I.; Kent, S. J.; Ndhlovu, L. C.; O'Connor, S. L.; Scanga, C. A.
10.1101/2022.12.14.520525 — immunology — Posted on 2022-12-16
1781 Intermittent Cytomegalovirus Infection Alters Neurobiological Metabolism and Induces Cognitive Deficits in Mice
Harrison, M. A. A.; Morris, S. L.; Rudman, G. A.; Rittenhouse, D. J.; Monk, C. H.; Sakamuri, S. S.; Jones, M. J.; Hasan, M. M.; Khatun, M. S.; Wang, H.; Garfinkel, L. P.; Norton, E. B.; Steele, C.; Kim, S.; Kolls, J. K.; Jazwinski, S. M.; Mostany, R.; Katakam, P. V. G.; Engler-Chiurazzi, E. B.; Zwezdaryk, K.
10.1101/2022.12.16.520745 — neuroscience — Posted on 2022-12-16
1783 Prenatal maternal stress promotes neural stem cell proliferation in the ependymal-subventricular zone of adult male offspring
Wang, Z.; Zhou, L.; Lee, C.; Shi, J.; Liu, L.; Yang, X.; Deng, Y.; Liu, J.; Wang, J.; Zhu, W.; Sun, Y. E.; Lin, Q.
10.1101/2022.12.15.520572 — neuroscience — Posted on 2022-12-16
1791 Identifying indels from WGS short reads of haploid genomes distinguishes variant-calling algorithms
Seah, Y. M.; Stewart, M. K.; Hoogestraat, D.; Ryder, M.; Cookson, B.; Salipante, S.; Hoffman, N.
10.1101/2022.12.14.520524 — bioinformatics — Posted on 2022-12-16
1797 Cell Tree Rings: the shape of somatic evolution as a human aging timer
Csordas, A.; Sipos, B.; Kurucova, T.; Volfova, A.; Zamola, F.; Tichy, B.; Hicks, D. G.
10.1101/2022.12.14.520419 — genomics — Posted on 2022-12-16
1799 Towards a General Approach for Bat Echolocation Detection and Classification
Mac Aodha, O.; Martinez Balvanera, S.; Damstra, E.; Cooke, M.; Eichinski, P.; Browning, E.; Barataud, M.; Boughey, K.; Coles, R.; Giacomini, G.; Mac Swiney G., M. C.; Obrist, M. K.; Parsons, S.; Sattler, T.; Jones, K.
10.1101/2022.12.14.520490 — ecology — Posted on 2022-12-16
1806 Cellular integration with a subretinal honeycomb-shaped prosthesis
Bhuckory, M. B.; Chen, Z. C.; Wang, B.; Shin, A.; Huang, T.; Galambos, L.; Vounotrypidis, E.; Mathieson, K.; Kamins, T.; Palanker, D.
10.1101/2022.12.15.520681 — neuroscience — Posted on 2022-12-16
1808 Using in silico perturbational approach to identify critical areas in schizophrenia
Mana, L.; Vila-Vidal, M.; Kockeritz, C.; Aquino, K.; Fornito, A.; Kringelbach, M. L.; Deco, G.
10.1101/2022.12.15.520260 — neuroscience — Posted on 2022-12-16
1809 Genome and Genetic Engineering of the House Cricket (Acheta domesticus) Applications for Sustainable Agriculture
Dossey, A. T.; Oppert, B.; Chu, F.-C.; Lorenzen, M. D.; Scheffler, B.; Simpson, S.; Koren, S.; Johnston, J. S.; Kataoka, K.; Ide, K.
10.1101/2022.12.14.520443 — genomics — Posted on 2022-12-16
1813 Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection
Guenthoer, J.; Lilly, M.; Starr, T. N.; Dadonaite, B.; Lovendahl, K. N.; Croft, J. T.; Stoddard, C. I.; Chohan, V.; Ding, S.; Ruiz, F.; Kopp, M. S.; Finzi, A.; Bloom, J. D.; Chu, H. Y.; Lee, K. K.; Overbaugh, J.
10.1101/2022.12.15.520606 — immunology — Posted on 2022-12-16
1817 Molecular profiling in HNSCC patients targets potential responsiveness to ICIs
Sacconi, A.; Muti, P.; Pulito, C.; Pellini, R.; Strano, S.; Bossi, P.; Blandino, G.
10.1101/2022.12.16.520703 — cancer biology — Posted on 2022-12-16
1818 Chiral and nematic phases of flexible active filaments
Dunajova, Z.; Mateu, B.; Radler, P.; Lim, K.; Velicky, P.; Danzl, J. G.; Wong, R. W.; Elgeti, J.; Hannezo, E.; Loose, M.
10.1101/2022.12.15.520425 — biophysics — Posted on 2022-12-16
1827 Co-occurring mutations in the POLE exonuclease and non-exonuclease domains define a unique subset of highly mutagenic tumors.
Shah, S. S.; Demidova, E. V.; Ringenbach, S.; Faezov, B.; Andrake, M.; Mur, P.; Viana-Errasti, J.; Xiu, J.; Swensen, J.; Valle, L.; Dunbrack, R.; Hall, M. J.; Arora, S.
10.1101/2022.12.15.520593 — cancer biology — Posted on 2022-12-16
1831 CAAStools, a toolbox to identify and test Convergent Amino Acid Substitutions.
Barteri, F.; Valenzuela, A.; Farre, X.; Juan, D.; Muntane, G.; Esteve-Altava, B.; Navarro, A.
10.1101/2022.12.14.520422 — bioinformatics — Posted on 2022-12-16
1832 A Noninvasive Skin Biopsy of Free Nerve Endings via Realtime Third-Harmonic Microscopy
Wu, P. J.; Tseng, H.-C.; Chao, C.-C.; Liao, Y.-H.; Yen, C.-T.; Lin, W.-Y.; Hsieh, S.-T.; Sun, W.-Z.; Sun, C.-K.
10.1101/2022.12.14.520369 — bioengineering — Posted on 2022-12-16
1833 3D-printed polymeric scaffolds with optimized architecture to repair a sheep metatarsal critical-size bone defect
GAROT, C.; Schoffit, S.; Monfoulet, C.; Machillot, P.; DEROY, C.; ROQUES, S.; VIAL, J.; Vollaire, J.; Renard, M.; GHANEM, H.; El-Hafci, H.; DECAMBRON, A.; Josserand, V.; BORDENAVE, L.; BETTEGA, G.; DURAND, M.; MANASSERO, M.; VIATEAU, V.; LOGEART-AVRAMOGLOU, D.; PICART, C.
10.1101/2022.12.14.520447 — bioengineering — Posted on 2022-12-16
1834 MSL2 targets histone genes in Drosophila virilis
Xie, M.; Hodkinson, L. J.; Comstra, H. S.; Diaz-Saldana, P. P.; Gilbonio, H. E.; Gross, J. L.; Chavez, R. M.; Puckett, G. L.; Aoki, T.; Schedl, P.; Rieder, L. E.
10.1101/2022.12.14.520423 — genetics — Posted on 2022-12-16
1838 Kestrels of the same colony do not overwinter together
Garcia-Macia, J.; Chaouni, M.; Morollon, S.; Bustamante, J.; Lopez-Ricaurte, L.; Martinez-Dalmau, J.; Rodriguez-Moreno, B.; Urios, V.
10.1101/2022.12.14.520401 — zoology — Posted on 2022-12-16
1839 A Cancer-Associated Fibroblast Classification Framework for Single-Cell Data
Cords, L.; Tietscher, S.; Anzeneder, T.; Langwieder, C.; Rees, M.; de Souza, N.; Bodenmiller, B.
10.1101/2022.12.14.520398 — cancer biology — Posted on 2022-12-16
1846 mRNA-mediated induced regeneration of the corneal endothelium
Marshall, M.; Ohman, L.; Samasa, B.; Papp, T.; Parhiz, H.; Rompolas, P.
10.1101/2022.12.15.520611 — cell biology — Posted on 2022-12-16
1847 SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response
Krawczyk, P. S.; Gewartowska, O.; Mazur, M.; Orzel, W.; Matylla-Kulinska, K.; Jelen, S.; Turowski, P.; Spiewla, T.; Tarkowski, B.; Tudek, A.; Brouze, A.; Wesolowska, A.; Nowis, D.; Golab, J.; Kowalska, J.; Jemielity, J.; Dziembowski, A.; Mroczek, S.
10.1101/2022.12.01.518149 — immunology — Posted on 2022-12-16
1849 VEGF-C expressing Tumor-Associated Macrophages decrease hematogenous metastatic dissemination and normalizes the tumor vasculature
Ferreira, S. d. S.; Wallmann, T.; Kerzel, T.; Wallerius, M.; Landwehr, L. S.; Agardy, D. A.; Bergh, J.; Bartish, M.; Hartman, J.; Squadrito, M. L.; Rolny, C.
10.1101/2022.01.26.468593 — cancer biology — Posted on 2022-12-16
1850 Restoring glucose homeostasis with stomach-derived human insulin-secreting organoids
Huang, X.; Gu, W.; Zhang, J.; Lan, Y.; Colarusso, J. L.; Li, S.; Pertl, C.; Lu, J.; Kim, H.; Zhu, J.; Sevigny, J.; Zhou, Q.
10.1101/2022.12.15.520488 — cell biology — Posted on 2022-12-16
1851 Piccolino regulates the architecture of the ribbon at cochlear inner hair cell synapses
Wichmann, C.; Michanski, S.; Kapoor, R.; Steyer, A. M.; Möbius, W.; Früholz, I.; Ackermann, F.; Gültas, M.; Garner, C. C.; Hamra, F. K.; Neef, J.; Strenzke, N.; Moser, T.
10.1101/2022.12.15.520589 — neuroscience — Posted on 2022-12-16
1852 Gba1 deletion causes immune hyperactivation and microbial dysbiosis through autophagic defects
Atilano, M. L.; Hull, A.; Romila, C.; Adams, M. L.; Dyson, M.; Urena, E.; Wildfire, J.; Ivan-Castillo-Quan, J.; Partridge, L.; Kinghorn, K. J.
10.1101/2022.12.15.520449 — neuroscience — Posted on 2022-12-16
1853 Transposable elements contribute to the establishment of the glycine shuttle in Brassicaceae species
Triesch, S.; Denton, A. K.; Buchmann, J. P.; Reichel-Deland, V.; Martins Guerreiro, R. N. F.; Schlueter, U.; Stich, B.; Weber, A. P. M.
10.1101/2022.12.06.519256 — plant biology — Posted on 2022-12-16
1854 T cell landscape definition by multi-omics identifies Galectin-9 as novel immunotherapy target in chronic lymphocytic leukemia
Cid, L. L.; Leong, J. K.; Botana, I. F.; Paul, Y.; Wierz, M.; Floerchinger, A.; Gonder, S.; Pagano, G.; Chazotte, M.; Bestak, K.; Schifflers, C.; Iskar, M.; Roider, T.; Mallm, J.-P.; Cosma, A.; Campton, D. E.; Gerhard-Hartmann, E.; Rosenwald, A.; Colomer, D.; Campo, E.; Shapiro, D.; Dietrich, S.; Lichter, P.; Moussay, E.; Paggetti, J.; Zapatka, M.; Seiffert, M.
10.1101/2022.12.15.519719 — cancer biology — Posted on 2022-12-16
1858 Evaluating hippocampal replay without a ground truth
Takigawa, M.; Huelin Gorriz, M.; Tirole, M.; Bendor, D.
10.1101/2022.12.12.520040 — neuroscience — Posted on 2022-12-16
1859 Deleterious effects of thermal and water stresses on life history and physiology: a case study on woodlouse
DEPEUX, C.; BRANGER, A.; MOULIGNIER, T.; MOREAU, J.; Lemaitre, J.-F.; DECHAUME-MONCHARMONT, F.-X.; LAVERRE, T.; PAULHAC, H.; GAILLARD, J.-M.; BELTRAN-BECH, S.
10.1101/2022.09.26.509512 — evolutionary biology — Posted on 2022-12-16
1861 Species-specific LUBAC-mediated M1 ubiquitination regulates necroptosis by segregating the cellular distribution and fate of activated MLKL
Weinelt, N.; Waechtershaeuser, K. N.; Smith, S.; Andrieux, G.; Das, T.; Jeiler, B.; Roedig, J.; Feist, L.; Rotter, B.; Boerries, M.; Pampaloni, F.; van Wijk, S. J. L.
10.1101/2022.12.08.519265 — cell biology — Posted on 2022-12-16
1862 Jaccard dissimilarity in stochastic community models based on the species-independence assumption
Iritani, R.; Ontiveros, V. L. J.; Alonso, D.; Capitan, J. A.; Godsoe, W.; Tatsumi, S.
10.1101/2022.12.13.520233 — ecology — Posted on 2022-12-16
1866 Truncating ASXL1 mutations in Bohring-Opitz Syndrome dysregulate canonical and non-canonical Wnt Signaling
Lin, I.; Wei, A.; Awamleh, Z.; Singh, M.; Ning, A.; Herrera, A.; Russell, B. E.; Weksberg, R. A.; ARBOLEDA, V. A.
10.1101/2022.12.15.520167 — genetics — Posted on 2022-12-15
1867 Human retina trades single-photon detection for high-fidelity contrast encoding
Kilpelainen, M.; Westo, J.; Laihi, A.; Takeshita, D.; Rieke, F.; Ala-Laurila, P.
10.1101/2022.12.15.520020 — neuroscience — Posted on 2022-12-15
1871 Comparison of two multi-trait association testing methods and sequence-based fine mapping of six QTL in Swiss Large White pigs
Noskova, A.; Mehrotra, A.; Kadri, N. K.; Llores-Villas, A.; Neuenschwander, S.; Hofer, A.; Pausch, H.
10.1101/2022.12.13.520268 — genomics — Posted on 2022-12-15
1874 The DeepFaune initiative: a collaborative effort towards the automatic identification of the French fauna in camera-trap images
Rigoudy, N.; Benyoub, A.; Besnard, A.; Birck, C.; Bollet, Y.; Bunz, Y.; Chiffard Carriburu, J.; Caussimont, G.; Chetouane, E.; Cornette, P.; Delestrade, A.; De Backer, N.; Dispan, L.; Le Brah, M.; Duhayer, J.; Elder, J.-F.; Fanjul, J.-B.; Fonderflick, J.; Froustey, N.; Garel, M.; Gaudry, W.; Gerard, A.; Gimenez, O.; Hemery, A.; Hemon, A.; Jullien, J.-M.; Malafosse, I.; Marginean, M.; Prunet, V.; Rabault, J.; Randon, M.; Regnier, A.; Ribiere, R.; Ricci, J.-C.; Ruette, S.; Sentilles, J.; Siefert, N.; Smith, B.; Terpereau, G.; Thuiller, W.; Uzal, A.; Vautrain, V.; Dussert, G.; Spataro, B.; Miele,
10.1101/2022.03.15.484324 — ecology — Posted on 2022-12-15
1876 An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
Ader, N. R.; Chen, L.; Surovtsev, I. V.; Chadwick, W. L.; King, M. C.; Lusk, C. P.
10.1101/2022.12.12.520126 — cell biology — Posted on 2022-12-15
1879 Evaluating hippocampal replay without a ground truth
Takigawa, M.; Huelin Gorriz, M.; Tirole, M.; Bendor, D.
10.1101/2022.12.12.520040 — neuroscience — Posted on 2022-12-15
1882 Is mild ADHD beneficial: Brain criticality is maximal with moderate ADHD symptom scores
Hirvonen, J.; Haque, H.; Wang, S. H.; Simola, J.; Morales-Munoz, I.; Cowley, B. U.; Palva, J. M.; Palva, S.
10.1101/2022.12.14.519751 — neuroscience — Posted on 2022-12-15
1883 Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS
Mora, S.; von Huth Friis, R.; Stuckert, A.; Noes-Holt, G.; Montanana-Rosell, R.; Toft Sorensen, A.; Selvan, R.; Allodi, I.
10.1101/2022.12.15.520568 — neuroscience — Posted on 2022-12-15
1884 Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain
Sulzer, D.; Hobson, B.; Stanley, A.; De Los Santos, M.; Culbertson, B.; Mosharov, E.; Sims, P.
10.1101/2022.12.14.520294 — neuroscience — Posted on 2022-12-15
1885 Functional dissociations between prefrontal and parietal cortex during task switching: A combined fMRI and TMS study
Perianez, J. A.; Viejo-Sobera, R.; Lubrini, G.; Alvarez-Linera, J.; Rodriguez Toscano, E.; Moreno, M. D.; Arango, C.; Redolar-Ripoll, D.; M. Marron, E.; Rios-Lago, M.
10.1101/2022.12.15.520659 — neuroscience — Posted on 2022-12-15
1886 Effective methods for bulk RNA-Seq deconvolution using scnRNA-Seq transcriptomes
Avila Cobos, F.; Najaf Panah, M. J.; Epps, J.; Long, X.; Man, T.-K.; Chiu, H.-S.; Chomsky, E.; Kiner, E.; Krueger, M. J.; di Bernardo, D.; Voloch, L.; Molenaar, J.; van Hooff, S. R.; Westermann, F.; Jansky, S.; Redell, M. L.; Mestdagh, P.; Sumazin, P.
10.1101/2022.12.13.520241 — systems biology — Posted on 2022-12-15
1888 NAD+ biosynthesis as a collateral lethality target for precision oncology
Muller, F. L.; Deng, P.; Satani, N.; Lin, Y.-H.; Hammoudi, N.; Mohapatra, G.; Asara, J. M.; DePinho, R. A.
10.1101/2022.12.13.518967 — cancer biology — Posted on 2022-12-15
1889 De novo design of high-affinity protein binders to bioactive helical peptides
Vazquez Torres, S.; Leung, P. J. Y.; Lutz, I. D.; Venkatesh, P.; Watson, J. L.; Hink, F.; Huynh, H.-H.; Yeh, A. H.-W.; Juergens, D.; Bennett, N. R.; Hoofnagle, A. N.; Huang, E.; MacCoss, M. J.; Exposit, M.; Lee, G. R.; Levine, P. M.; Li, X.; Lamb, M.; Korkmaz, E. N.; Nivala, J.; Stewart, L.; Rogers, J. M.; Baker, D.
10.1101/2022.12.10.519862 — bioengineering — Posted on 2022-12-15
1895 The Kelch13 compartment is a hub of highly divergent vesicle trafficking proteins in malaria parasites
Schmidt, S.; Wichers-Misterek, J. S.; Behrens, H. M.; Birnbaum, J.; Henshall, I.; Jonscher, E.; Flemming, S.; Castro-Pena, C.; Spielmann, T.
10.1101/2022.12.15.520209 — cell biology — Posted on 2022-12-15
1898 Diversity and pathobiology of an ilarvirus unexpectedly detected in diverse host plants and in global sequencing data
Rivarez, M. P. S.; Faure, C.; Svanella-Dumas, L.; Pecman, A.; Tusek-Znidaric, M.; Schönegger, D.; De Jonghe, K.; Blouin, A.; Massart, S.; Ravnikar, M.; Kutnjak, D.; Marais, A.; Candresse, T.
10.1101/2022.12.15.520526 — microbiology — Posted on 2022-12-15
1902 Autofluorescence is a biomarker of neural stem cell activation state
Morrow, C. S.; Tweed, K.; Arndt, Z. P.; Walsh, A. J.; Peng, B.; Risgaard, R. D.; Klosa, P. C.; Chi, M. M.; Wallace, E. P.; Jones, M. V.; Roopra, A.; Skala, M. C.; Moore, D. L.
10.1101/2022.12.14.520430 — neuroscience — Posted on 2022-12-15
1903 Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism
Reynolds, L. M.; Hernandez, G.; Popescu, C.; MacGowan, D.; Nouel, D.; Cuesta, S.; Burke, S.; Savell, K.; Zhao, J.; Restrepo-Lozano, J. M.; Pokinko, M.; Giroux, M.; Israel, S.; Orsini, T.; He, S.; Wodzinski, M.; Epelbaum, J. G.; Trudeau, L.-E.; Kolb, B.; Day, J. J.; Flores, C.
10.1101/2022.12.14.520468 — neuroscience — Posted on 2022-12-15
1904 Emergence of a time-independent population code in auditory cortex enables sound categorization and discrimination learning
Bagur, S.; Bourg, J.; Kempf, A.; Tarpin, T.; Bergaoui, K.; Guo, Y.; Ceballo, S.; Schwenkgrub, J.; Puel, J.-L.; Bourien, J.; Bathellier, B.
10.1101/2022.12.14.520391 — neuroscience — Posted on 2022-12-15
1905 The FMRF-NH2 Gated Sodium Channel of Biomphalaria glabrata: Localization and Expression Following Infection by Schistosoma mansoni
Miller, M. W.; Vicente, L. C.; Behra, M.; Torres, A.; Mendez, P.; Rosa-Casillas, M.; Bracho, D. P.; Rosenthal, J. J.
10.1101/2022.12.15.520648 — neuroscience — Posted on 2022-12-15
1908 Reconstructing Spatio-Temporal Trajectories of Visual Object Memories in the Human Brain
Lifanov, J.; Griffiths, B. J.; Linde-Domingo, J.; Ferreira, C. S.; Wilson, M.; Mayhew, S. D.; Charest, I.; Wimber, M.
10.1101/2022.12.15.520591 — neuroscience — Posted on 2022-12-15
1909 Gba1 deletion causes immune hyperactivation and microbial dysbiosis through autophagic defects
Atilano, M. L.; Hull, A.; Romila, C.; Adams, M. L.; Dyson, M.; Urena, E.; Ivan-Castillo-Quan, J.; Partridge, L.; Kinghorn, K. J.; Wildfire, J.
10.1101/2022.12.15.520449 — neuroscience — Posted on 2022-12-15
1910 Encoding social preference by interhemispheric neurons in the Insula
Glangetas, C.; Ladeveze, E.; Guillaumin, A.; Gauthier, M.; Doudnikoff, E.; Bezard, E.; Taupignon, A.; Baufreton, J.; GEORGES, F.
10.1101/2022.12.15.520538 — neuroscience — Posted on 2022-12-15
1913 Deep learning based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra.
Burkert, N.; Roy, S.; Haeusler, M.; Wuttke, D.; Mueller, S.; Wiemer, J.; Hollmann, H.; Ramirez-Franco, J.; Benkert, J.; Fauler, M.; Duda, J.; Poetschke, C.; Goaillard, J.-M.; Muenchmeyer, M.; Parlato, R.; Liss, B.
10.1101/2022.12.14.520432 — neuroscience — Posted on 2022-12-15
1916 Eye structure shapes neuron function in Drosophila motion vision
Zhao, A.; Gruntman, E.; Nern, A.; Iyer, N. A.; Rogers, E. M.; Koskela, S.; Siwanowicz, I.; Dreher, M.; Flynn, M. A.; Laughland, C. W.; Ludwig, H. D.; Thomson, A. G.; Moran, C. P.; Gezahegn, B.; Bock, D. D.; Reiser, M. B.
10.1101/2022.12.14.520178 — neuroscience — Posted on 2022-12-15
1921 Safety Recommendations for Temporal Interference Stimulation in the Brain
Cassara, A. M.; Newton, T. H.; Zhuang, K.; Regel, S.; Achermann, P.; Kuster, N.; Neufeld, E.
10.1101/2022.12.15.520077 — neuroscience — Posted on 2022-12-15
1923 Cell non-autonomous control of autophagy and metabolism by glial cells
Metcalf, M. G.; Monshietehadi, S.; Sahay, A.; Frakes, A. E.; Durieux, J.; Velichkovska, M.; Mena, C.; Farinas, A.; Sanchez, M.; Dillin, A.
10.1101/2022.12.15.520639 — neuroscience — Posted on 2022-12-15
1924 Neurodegeneration Risk Factor, EIF2AK3 (PERK), Influences Tau Protein Aggregation
Park, G.; Xu, K.; Chea, L.; Kim, K.; Safarta, L.; Song, K.-H.; Wu, J.; Park, S.; Min, H.; Hiramatsu, N.; Han, J.; Lin, J. H.
10.1101/2022.12.14.520487 — neuroscience — Posted on 2022-12-15
1925 A deeply conserved protease, acylamino acid-releasing enzyme (AARE), acts in ageing in Physcomitrella and Arabidopsis
Hoernstein, S. N. W.; Oezdemir, B.; van Gessel, N.; Miniera, A. A.; Rogalla von Bieberstein, B.; Nilges, L.; Schweikert Farinha, J.; Komoll, R.; Glauz, S.; Weckerle, T.; Scherzinger, F.; Rodriguez-Franco, M.; Mueller-Schuessele, S. J.; Reski, R.
10.1101/2022.05.18.492440 — plant biology — Posted on 2022-12-15
1926 Tumor-immune metaphenotypes orchestrate an evolutionary bottleneck that promotes metabolic transformation
West, J.; Rentzeperis, F.; Adam, C.; Bravo, R.; Luddy, K. A.; Robertson-Tessi, M.; Anderson, A. R. A.
10.1101/2022.06.03.493752 — cancer biology — Posted on 2022-12-15
1927 Cytidine deaminase regulates mitochondrial biogenesis in pancreatic cancer cells
Frances, A.; Lumeau, A.; Stuani, L.; Gayral, M.; Salland, E.; Bery, N.; Pagan, D.; Hanoun, N.; Torrisani, J.; Lemarie, A.; Portais, J.-C.; Buscail, L.; Dusestti, N.; Sarry, J.-E.; Cordelier, P.
10.1101/2022.12.15.520429 — cancer biology — Posted on 2022-12-15
1929 Novel green fluorescent polyamines to analyze ATP13A2 and ATP13A3 activity in the mammalian polyamine transport system
Houdou, M. C.; Jacobs, N.; Coene, J.; Azfar, M.; Vanhoutte, R.; Van den Haute, C.; Eggermont, J.; Daniels, V.; Verhelst, S. H. L.; Vangheluwe, P.
10.1101/2022.12.15.520427 — biochemistry — Posted on 2022-12-15
1930 Structural insights into viral genome replication by the Severe fever with thrombocytopenia syndrome virus L protein
Williams, H. M.; Thorkelsson, S. R.; Vogel, D.; Milewski, M.; Busch, C.; Cusack, S.; Grunewald, K.; Quemin, E.; Rosenthal, M.
10.1101/2022.08.25.505333 — biochemistry — Posted on 2022-12-15
1931 Scale space calibrates present and subsequent spatial learning in Barnes maze in mice
Tachiki, Y.; Suzuki, Y.; Kurahashi, M.; Oki, K.; Mavuk, O.; Nakagawa, T.; Ishihara, S.; Gyoten, Y.; Yamamoto, A.; Imayoshi, I.
10.1101/2022.12.14.520510 — animal behavior and cognition — Posted on 2022-12-15
1933 Transcriptional Responses of Cancer Cells to Heat Shock-Inducing Stimuli Involve Amplification of Robust HSF1 Binding
Ghosh Dastidar, S.; De Kumar, B.; Lauckner, B.; Parrello, D.; Perley, D.; Vlasenok, M.; Tyagi, A.; Koney-Kwaku Koney, N.; Abbas, A.; Nechaev, S.
10.1101/2022.12.14.519647 — genomics — Posted on 2022-12-15
1934 Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant
Wang, Q.; Martinez-Bonet, M.; Kim, T.; Sparks, J.; Ishigaki, K.; Chen, X.; Sudman, M.; Aguiar, V.; Hernandez, M. C.; Wactor, A.; Wauford, B.; Marion, M.; Gutierrez-Arcelus, M.; Bowes, J.; Eyre, S.; Nordal, E.; Prahalad, S.; Rygg, M.; Videm, V.; Raychaudhuri, S.; Weirauch, M.; Langefeld, C.; Thompson, S.; Nigrovic, P. A.
10.1101/2022.12.15.520628 — genetics — Posted on 2022-12-15
1935 Airborne environmental DNA captures terrestrial vertebrate diversity in nature
Lynggaard, C.; Froslev, T. G.; Johnson, M. S.; Olsen, M. T.; Bohmann, K.
10.1101/2022.10.24.512985 — ecology — Posted on 2022-12-15
1938 METTL3 maintains epithelial homeostasis through m6A-dependent regulation of chromatin modifiers
Maldonado-Lopez, A. M.; Huang, S.; Pacella, G.; Ko, E. K.; Shen, H.; Stoute, J.; Sinkfield, M.; Anderson, A.; Prouty, S.; Li, H.; Seykora, J. T.; Liu, K. F.; Capell, B. C.
10.1101/2022.12.14.520484 — molecular biology — Posted on 2022-12-15
1943 Lunaemycins, new cyclic hexapeptide antibiotics from the cave moonmilk-dweller Streptomyces lunaelactis MM109
Martinet, L.; Naome, A.; Rezende, L. C. D.; Tellatin, D.; Pignon, B.; Docquier, J.-D.; Sannio, F.; Baiwir, D.; Mazzucchelli, G.; Frederich, M.; Rigali, S.
10.1101/2022.12.15.520542 — microbiology — Posted on 2022-12-15
1944 Low-cost gold-leaf electrode as a platform for Escherichia coli immuno-detection
Podunavac, I.; Kukkar, M.; Leguillier, V.; Rizzotto, F.; Pavlovic, Z.; Janjusevic, L.; Costache, V.; Radonic, V.; Vidic, J.
10.1101/2022.12.14.520406 — microbiology — Posted on 2022-12-15
1946 Reverse-zoonoses of 2009 H1N1 pandemic influenza A viruses and evolution in United States swine results in viruses with zoonotic potential
Markin, A.; Ciacci Zanella, G.; Arendsee, Z. W.; Zhang, J.; Krueger, K. M.; Gauger, P. C.; Vincent Baker, A. L.; Anderson, T. K.
10.1101/2022.12.15.520479 — microbiology — Posted on 2022-12-15
1947 Identification of a key genetic factor governing arabinan utilization in the gut microbiome suggests a novel therapeutic target for constipation
Zhang, C.; Yu, L.; Ma, C.; Jiang, S.; Wang, S.; Tian, F.; Xue, Y.; Zhao, J.; Zhang, H.; Liu, L.; Chen, W.; Huang, S.; Zhang, J.; Zhai, Q.
10.1101/2022.12.15.518621 — microbiology — Posted on 2022-12-15
1948 Threshold Selection for Brain Connectomes
Theis, N.; Rubin, J.; Cape, J.; Iyengar, S.; Prasad, K. M.
10.1101/2021.10.09.463759 — neuroscience — Posted on 2022-12-15
1949 Expression of substance P, NPY and their Receptors Is Altered in Major Depression
Barde, S.; Aguila, J.; Zhong, W.; Solarz, A.; Mei, I.; Prud'homme, J.; Palkovits, M.; Turecki, G.; Mulder, J.; Uhlen, M.; Nagy, C.; Mechawar, N.; Hedlund, E.; Hokfelt, T.
10.1101/2022.12.14.516867 — neuroscience — Posted on 2022-12-15
1950 Reciprocal feature encoding by corticalexcitatory and inhibitory neurons.
Duszkiewicz, A. J.; Orhan, P.; Skromne Carrasco, S.; Brown, E.; Owczarek, E.; Rojas Vite, G.; Wood, E. R.; Peyrache, A.
10.1101/2022.03.14.484357 — neuroscience — Posted on 2022-12-15
1952 Tools for comprehensive reconstruction and analysis of Drosophila motor circuits
Azevedo, A. W.; Lesser, E.; Mark, B.; Phelps, J. S.; Elabbady, L.; Kuroda, S.; Sustar, A. E.; Moussa, A. J.; Kandelwal, A.; Dallmann, C. J.; Agrawal, S.; Lee, S.-Y. J.; Pratt, B. G.; Cook, A.; Skutt-Kakari, K.; Gerhard, S.; Lu, R.; Kemnitz, N.; Lee, K.; Halageri, A.; Castro, M.; Ih, D.; Gager, J.; Tammam, M.; Dorkenwald, S.; Collman, F. C.; Schneider-Mizell, C. M.; Brittain, D.; Jordan, C. S.; Dickinson, M. H.; Pacureanu, A.; Seung, H. S.; Macrina, T.; Lee, W.-C. A.; Tuthill, J. C.
10.1101/2022.12.15.520299 — neuroscience — Posted on 2022-12-15
1955 A set of orthogonal versatile interacting peptide tags for imaging cellular proteins
Suyama, A.; Devlin, K. L.; Macias Contreras, M.; Doh, J. K.; Shinde, U.; Beatty, K. E.
10.1101/2022.12.14.520515 — biochemistry — Posted on 2022-12-15
1956 Lectin-Seq: a method to profile lectin-microbe interactions in native communities
McPherson, R. L.; Isabella, C. R.; Walker, R. L.; Sergio, D.; Bae, S.; Gaca, T.; Raman, S.; Nguyen, L. T. T.; Wesener, D. A.; Halim, M.; Wuo, M. G.; Dugan, A.; Kerby, R.; Ghosh, S.; Rey, F. E.; Dhennezel, C.; Pishchany, G.; Vlamakis, H.; Alm, E. J.; Xavier, R. J.; Kiessling, L. L.
10.1101/2022.12.14.520458 — biochemistry — Posted on 2022-12-15
1957 A schema for digitized surface swab site metadata in open-source DNA sequence databases
Feng, B.; Daeschel, D.; Dooley, D.; Griffiths, E.; Allard, M. W.; Timme, R.; Chen, Y.; Snyder, A. B.
10.1101/2022.12.15.520583 — genomics — Posted on 2022-12-15
1958 Phylogenomics of the psychoactive mushroom genus Psilocybe and evolution of the psilocybin biosynthetic gene cluster
Bradshaw, A. J.; Ramirez-Cruz, V.; Awan, A. R.; Furci, G.; Guzman-Davalos, L.; Stamets, P.; Dentinger, B. T. M.
10.1101/2022.12.13.520147 — evolutionary biology — Posted on 2022-12-15
1960 Simultaneous inhibition of DNA-PK and Pol{Theta} improves integration efficiency and precision of genome editing
Wimberger, S.; Akrap, N.; Firth, M.; Brengdahl, J.; Engberg, S.; Schwinn, M. K.; Slater, M. R.; Lundin, A.; Hsieh, P.-P.; Li, S.; Cerboni, S.; Sumner, J.; Bestas, B.; Schiffthaler, B.; Magnusson, B.; Di Castro, S.; Iyer, P.; Bohlooly, M.; Machleidt, T.; Rees, S.; Engkvist, O.; Norris, T.; Cadogan, E.; Forment, J. V.; Svikovic, S.; Akcakaya, P.; Taheri-Ghahfarokhi, A.; Maresca, M.
10.1101/2022.12.15.520396 — molecular biology — Posted on 2022-12-15
1964 A framework for community curation of interspecies interactions literature
Cuzick, A.; Seager, J.; Wood, V.; Urban, M.; Rutherford, K.; Hammond-Kosack, K.
10.1101/2022.12.15.520601 — microbiology — Posted on 2022-12-15
1968 Robust hierarchically organized whole-brain patterns of dysconnectivity in schizophrenia spectrum disorders observed after Personalized Intrinsic Network Topography
Dickie, E. W.; Shahab, S.; Hawco, C.; Miranda, D.; Herman, G.; Argyelan, M.; Ji, J. L. W.; Jeyachandra, J.; Anticevic, A.; Malhotra, A. K.; Voineskos, A. N.
10.1101/2022.12.13.520333 — neuroscience — Posted on 2022-12-15
1974 The HDAC inhibitor trichostatin A impairs pancreatic β-cell function through an epigenome-wide reprogramming
Oger, F.; Moreno, M.; Derhourhi, M.; Thiroux, B.; Berberian, L.; Bourouh, C.; Durand, E.; Amanzougarene, S.; Badreddine, A.; Blanc, E.; Molendi-Coste, O.; Pineau, L.; Pasquetti, G.; Rolland, L.; Carney, C.; Bornaque, F.; Courty, E.; Gheeraert, C.; Eeckhoute, J.; Dombrowicz, D.; Kerr-Conte, J.; Pattou, F.; Staels, B.; Froguel, P.; Bonnefond, A.; ANNICOTTE, J.-S.
10.1101/2022.12.14.519294 — genomics — Posted on 2022-12-15
1978 Human intestinal epithelial cells can internalize luminal fungi via LC3-associated phagocytosis
Cohen-Kedar, S.; Shaham Barda, E.; Rabinowitz, K. M.; Keizer, D.; Abu-Taha, H.; Schwartz, S.; Kaboub, K.; Baram, L.; Sadot, E.; White, I.; Wasserberg, N.; Wolff-Bar, M.; Levy-Barda, A.; Dotan, I.
10.1101/2022.12.14.520372 — immunology — Posted on 2022-12-15
1979 Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response
Dykema, A. G.; Zhang, J.; Zhang, B.; Cheung, L. S.; Zeng, Z.; Cherry, C. M.; Li, T.; Caushi, J. X.; Nishimoto, M.; Connor, S.; Ji, Z.; Munoz, A. J.; Hou, W.; Zhan, W.; Singh, D.; Rashid, R.; Mitchell-Flack, M.; Bom, S.; Tam, A.; Wang, Y.; Sawosik, C. A.; Tirado, L. E.; Tomasovic, L. M.; VanDyke, D.; Spangler, J. B.; Anagnostou, V.; Yang, S.; Spicer, J.; Rayes, R.; Taube, J. M.; Brahmer, J. R.; Forde, P. M.; Yegnasubramanian, S.; Ji, H.; Pardoll, D. M.; Smith, K. N.
10.1101/2022.12.13.520329 — immunology — Posted on 2022-12-15
1982 Enterotypes of the human gut mycobiome
Lai, S.; Yan, Y.; Pu, Y.; Lin, S.; Qiu, J.-G.; Jiang, B.-H.; Keller, M.; Wang, M.; Bork, P.; Chen, W.-H.; Zheng, Y.; Zhao, X.-M.
10.1101/2022.12.13.520343 — bioinformatics — Posted on 2022-12-15
1985 A Translational Tissue Engineering Approach to Airway Reconstruction Leveraging Decellularized Meniscus and Cartilage Progenitor Cells
Gehret, P. M.; Ali Akbari Ghavimi, S.; Dumas, A.; Borek, R. C.; Aronson, M.; Carpenter, K.; Jacobs, I. N.; Gottardi, R.
10.1101/2022.12.13.520352 — bioengineering — Posted on 2022-12-15
1989 Jaccard dissimilarity in stochastic community models based on the species-independence assumption
Iritani, R.; Ontiveros, V. L. J.; Alonso, D.; Capitan, J. A.; Godsoe, W.; Tatsumi, S.
10.1101/2022.12.13.520233 — ecology — Posted on 2022-12-15
1990 SARS-CoV-2 causes periodontal fibrosis by deregulating mitochondrial beta-oxidation
Gao, Y.; Kok, W. L.; Sharma, V.; Illsley, C. S.; Hanks, S.; Tredwin, C.; Hu, B.
10.1101/2022.12.15.520561 — molecular biology — Posted on 2022-12-15
1992 Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T-cell recognition epitopes
Muik, A.; Lui, B. G.; Diao, H.; Fu, Y.; Bacher, M.; Toker, A.; Grosser, J.; Ozhelvaci, O.; Grikscheit, K.; Hoehl, S.; Kohmer, N.; Lustig, Y.; Regev-Yochay, G.; Ciesek, S.; Beguir, K.; Poran, A.; Tuereci, O.; Sahin, U.
10.1101/2022.12.15.520569 — immunology — Posted on 2022-12-15
1994 Crowdsourcing Temporal Transcriptomic Coronavirus Host Infection Data: resources, guide, and novel insights.
Flynn, J.; Ahmadi, M.; McFarland, C.; Kubal, M.; Taylor, M.; Cheng, Z.; Torchia, E. C.; Edwards, M.
10.1101/2022.12.14.520483 — bioinformatics — Posted on 2022-12-15
1996 Air-seq: Measuring air metagenomic diversity in an agricultural ecosystem
Giolai, M.; Verweij, W.; Pearson, N.; Nicolson, P.; Leggett, R. M.; Clark, M. D.
10.1101/2022.12.13.520298 — genomics — Posted on 2022-12-15
1997 Comparison of two multi-trait association testing methods and sequence-based fine mapping of six QTL in Swiss Large White pigs
Noskova, A.; Mehrotra, A.; Kadri, N. K.; Llores-Villas, A.; Neuenschwander, S.; Hofer, A.; Pausch, H.
10.1101/2022.12.13.520268 — genomics — Posted on 2022-12-15
1998 Understanding the mechanism of the SARS CoV-2 coinfection with other respiratory viruses
Ponnusamy, K.; Srinivasan, R. V.; Marwal, R.; Datta, M.; Dhar, M. S.; Chaudhary, U.; Sharma, U.; Kumari, S.; Sharma, K.; Gogia, H.; Madan, P.; Kabra, S.; Rakshit, P.
10.1101/2022.12.15.520197 — genomics — Posted on 2022-12-15
1999 Egg hatching success is significantly influenced by the time of thermal stress in multiple hard tick species
Ajayi, O.; Oyen, K.; Davies, B.; Finch, G.; Piller, B. D.; Harmeyer, A. A.; Wendeln, K.; Perretta, C.; Rosendale, A. J.; Benoit, J. B.
10.1101/2022.12.13.518051 — ecology — Posted on 2022-12-15
2000 Machine Learning Reveals Genetic Modifiers of the Immune Microenvironment of Cancer
Riley-Gillis, B.; Tsaih, S.-W.; King, E.; Wollenhaupt, S.; Reeb, J.; Peck, A. R.; Wackman, K.; Lemke, A.; Rui, H.; Dezso, Z.; Flister, M. J.
10.1101/2022.12.13.520300 — cancer biology — Posted on 2022-12-15
2002 Positive selection in the genomes of two Papua New Guinean populations at distinct altitude levels
Andre, M.; Brucato, N.; Hudjasov, G.; Pankratov, V.; Yermakovich, D.; Kreevan, R.; Kariwiga, J.; Muke, J.; Boland, A.; Deleuze, J.-F.; Meyer, V.; Evans, N.; Cox, M. P.; Leavesley, M.; Dannemann, M.; Org, T.; Metspalu, M.; Mondal, M.; Ricaut, F.-X.
10.1101/2022.12.15.520226 — evolutionary biology — Posted on 2022-12-15
2003 Non-target effects of ten essential oils on the egg parasitoid Trichogramma evanescens
van Oudenhove, L.; Cazier, A.; Fillaud, M.; Lavoir, A.-V.; Fatnassi, H.; Perez, G.; Calcagno, V.
10.1101/2022.01.14.476310 — ecology — Posted on 2022-12-15
2004 Early human lung immune cell development and its role in epithelial cell fate
Barnes, J. L.; He, P.; Yoshida, M.; Worlock, K. B.; Lindeboom, R. G. H.; Suo, C.; Pett, J. P.; Wilbrey-Clark, A.; Dann, E.; Mamanova, L.; Richardson, L.; Oliver, A. J.; Pennycuick, A. L.; Allen-Hyttinen, J.; Herczeg, I. T.; Hynds, R. E.; Teixeira, V. H.; Haniffa, M.; Lim, K.; Sun, D.; Rawlins, E. L.; Polanski, K.; Lyons, P. A.; Marioni, J. C.; Tuong, Z. K.; Clatworthy, M. R.; Reading, J. L.; Janes, S. M.; Teichmann, S.; Meyer, K. B.; Nikolic, M. Z.
10.1101/2022.12.13.519713 — immunology — Posted on 2022-12-15
2010 Neural coding of distinct motor patterns during Drosophila courtship song
Shiozaki, H. M.; Wang, K.; Lillvis, J. L.; Xu, M.; Dickson, B. J.; Stern, D. L.
10.1101/2022.12.14.520499 — neuroscience — Posted on 2022-12-15
2011 Effects of neural noise on predictive model updating across the adult lifespan
Bornkessel-Schlesewsky, I.; Alday, P. M.; Corcoran, A. W.; Wilkinson, E. M.; Sharrad, I.; Kliegl, R.; Lewis, R. L.; Small, S. L.; Schlesewsky, M.
10.1101/2022.12.14.520501 — neuroscience — Posted on 2022-12-15
2012 Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence
Liang, X.; Sun, L.; Liao, X.; Lei, T.; Xia, M.; Duan, D.; Zeng, Z.; Xu, Z.; Men, W.; Wang, Y.; Tan, S.; Gao, J.-H.; Qin, S.; Tao, S.; Dong, Q.; Zhao, T.; He, Y.
10.1101/2022.12.15.520527 — neuroscience — Posted on 2022-12-15
2015 Transcriptome responses of the aphid vector Myzus persicae are shaped by identities of the host plant and the virus
Chesnais, Q.; Golyaev, V.; Velt, A.; Rustenholz, C.; Verdier, M.; Brault, V.; Pooggin, M. M.; Drucker, M.
10.1101/2022.07.18.500449 — plant biology — Posted on 2022-12-15
2016 Regulatory annotation identifies KAN1, MYB44 and PIF4 as regulators of Arabidopsis lincRNAs expressed in root
Liu, L.; Heidecker, M.; Depuydt, T.; Manosalva Perez, N.; Crespi, M.; Blein, T.; Vandepoele, K.
10.1101/2022.09.09.507345 — plant biology — Posted on 2022-12-15
2019 Highly multiplexed detection of microRNAs, proteins and small molecules using barcoded molecular probes and nanopore sequencing
Koch, C.; Reilly-ODonnell, B.; Gutierrez, R.; Lucarellli, C.; Siong Ng, F.; Gorelik, J.; Ivanov, A.; Edel, J.
10.1101/2022.12.13.520243 — biophysics — Posted on 2022-12-15
2024 MIDAS: a deep generative model for mosaic integration and knowledge transfer of single-cell multimodal data
He, Z.; Chen, Y.; Hu, S.; An, S.; Shi, J.; Liu, R.; Dong, G.; Shi, J.; Zhao, J.; Wang, J.; Zhu, Y.; Bo, X.; Ying, X.
10.1101/2022.12.13.520262 — bioinformatics — Posted on 2022-12-15
2028 Spatial transcriptome profiling of in vitro 3D tumouroids to study tumour-stroma interactions
Bakkalci, D.; Al-Badri, G.; Yang, W.; Nam, A.; Ling, Y.; Khurram, S. A.; Heavey, S.; Fedele, S.; Cheema, U.
10.1101/2022.12.13.520130 — bioengineering — Posted on 2022-12-15
2029 Multiparametric sensing of outer membrane vesicle-derived supported lipid bilayers demonstrates the specificity of bacteriophage interactions
Bali, K.; Lu, Z.; McCoy, R.; Treiber, J.; Savva, A.; Kaminski, C. F.; Salmond, G.; Salleo, A.; Mela, I.; Monson, R.; Owens, R. M.
10.1101/2022.12.13.520201 — bioengineering — Posted on 2022-12-15
2031 Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
Grosch, M.; Schraft, L.; Chan, A.; Kuechenhoff, L.; Rapti, K.; Ferreira, A.-M.; Kornienko, J.; Li, S.; Radke, M. H.; Kraemer, C.; Clauder-Muenster, S.; Perlas, E.; Gotthardt, M.; Dieterich, C.; vandenHoogenhof, M. M.; Grimm, D.; Steinmetz, L. M.
10.1101/2022.12.13.520227 — genetics — Posted on 2022-12-15
2032 Game of full siblings in Mendelian populations
Garay, J.; Szilagyi, A.; Varga, T.; csiszar, v.; Mori, T. F.
10.1101/2022.12.13.520274 — evolutionary biology — Posted on 2022-12-15
2039 ohun: an R package for diagnosing and optimizing automatic sound event detection
Araya-Salas, M.; Smith-Vidaurre, G.; Chaverri, G.; Brenes, J. C.; Chirino, F.; Elizondo-Calvo, J.; Rico-Guevara, A.
10.1101/2022.12.13.520253 — ecology — Posted on 2022-12-15
2041 IRE1 RNase controls CD95-mediated cell death
Pelizzari-Raymundo, D.; Pineau, R.; Papaioannou, A.; Zhou, X.; Martin, S.; Avril, T.; Le Gallo, M.; chevet, e.; Lafont, E.
10.1101/2022.02.25.481813 — cell biology — Posted on 2022-12-15
2042 Enhanced survival and low proliferation marks multifunctional virus specific memory CD4 T cells
Westerhof, L. M.; Noonan, J.; Hargrave, K. E.; Chimbayo, E. T.; Cheng, Z.; Purnell, T.; Jackson, M. R.; Borcherding, N.; MacLeod, M. K.
10.1101/2022.12.13.520219 — immunology — Posted on 2022-12-15
2044 Steroid hormone imbalance drives macrophage infiltration and Spp1/osteopontin+ foam cell differentiation in the prostate
Popovics, P.; Skalitzky, K. O.; Schroeder, E.; Jain, A.; Silver, S. V.; Van Fritz, F.; Uchtmann, K. S.; Vezina, C. M.; Ricke, W. A.
10.1101/2022.12.13.520247 — pathology — Posted on 2022-12-15
2045 ImmuneBuilder: Deep-Learning models for predicting the structures of immune proteins.
Abanades, B.; Wong, W. K.; Boyles, F.; Georges, G.; Bujotzek, A.; Deane, C. M.
10.1101/2022.11.04.514231 — bioinformatics — Posted on 2022-12-15
2046 Single-nucleus co-expression networks of dopaminergic neurons support iron accumulation as a plausible explanation to their vulnerability in Parkinson's disease
Gomez-Pascual, A.; Martirosyan, A.; Hebestreit, K.; Mameffe, C.; Poovathingal, S.; Belgard, T. G.; Altar, C. A.; Kottick, A.; Holt, M.; Hanson-Smith, V.; Cisterna, A.; Mighdoll, M.; Scannevin, R.; Guelfi, S.; Botia, J. A.
10.1101/2022.12.13.514863 — bioinformatics — Posted on 2022-12-15
2049 The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein
GARNER, K. E. L.; Salter, A.; Lau, C. K.; Manickam, G.; Villemant, C.; Granger, E. P.; McNee, G.; Woodman, P. G.; Davies, O. R.; Burke, B. E.; Allan, V. J.
10.1101/2022.04.13.488131 — cell biology — Posted on 2022-12-15
2050 Ciliary protein polycystin is required for renal tubulointerstitial fibrosis
Wu, M.; Wang, Y.; Jing, Y.; Chen, D.; Lin, J.; Yuan, M.; Tan, B.; Huang, D.; Hu, J.; Zhuang, S.; Ye, C.
10.1101/2021.11.03.467035 — molecular biology — Posted on 2022-12-15
2051 African army ants at the forefront of virome surveillance in a remote tropical forest
Fritz, M.; Reggiardo, B.; Filloux, D.; Claude, L.; Fernandez, E.; Mahe, F.; Kraberger, S.; Custer, J. M.; Becquart, P.; Ndong Mebaley, T.; Bohou Kombila, L.; Lenguiya, L. H.; Boundenga, L.; Mombo, I. M.; Maganga, G. D.; Niama, F. R.; Koumba, J.-S.; Ogliastro, M.; Yvon, M.; Martin, D.; Blanc, S.; Varsani, A.; Leroy, E.; Roumagnac, P.
10.1101/2022.12.13.520061 — microbiology — Posted on 2022-12-15
2052 Differentiation of leukocytes in bronchoalveolar lavage fluid samples using higher harmonic generation microscopy and deep learning
van Huizen, L. M. G.; Blokker, M.; Rip, Y.; Veta, M.; Mooij - Kalverda, K. A.; Bonta, P. I.; Duitman, J. W. W.; Groot, M. L.
10.1101/2022.12.12.520069 — immunology — Posted on 2022-12-15
2053 BCI learning phenomena can be explained by gradient-based optimization
Humphreys, P. C.; Daie, K.; Svoboda, K.; Botvinick, M.; Lillicrap, T. P.
10.1101/2022.12.08.519453 — neuroscience — Posted on 2022-12-15
2054 Polygenic Transcriptome Risk Scores Can Translate Genetic Results Between Species
Santhanam, N.; Sanchez-Roige, S.; Liang, Y.; Chitre, A.; Munro, D.; Chen, D.; Cheng, R.; Nyasimi, F.; Perry, M.; Gao, J.; George, A. M.; Gileta, A.; Holl, K.; Hughson, A.; King, C. P.; Lamparelli, A. C.; Martin, C. D.; Martinez, A. G.; Mi, S.; St. Pierre, C. L.; Tripi, J.; Wang, T.; Chen, H.; Flagel, S.; Ishiwari, K.; Meyer, P.; Saba, L.; Woods, L. S.; Polesskaya, O.; Palmer, A. A.; Im, H. K.
10.1101/2022.06.03.494719 — genomics — Posted on 2022-12-15
2055 Functional network organization of the mouse cortex determined by wide-field fluorescence imaging shares some --but not all-- properties revealed with simultaneous fMRI-BOLD
Vafaii, H.; Mandino, F.; Desrosiers-Gregoire, G.; O'Connor, D.; Shen, X.; Ge, X.; Herman, P.; Hyder, F.; Papademetris, X.; Chakravarty, M.; Crair, M.; Constable, R. T.; Lake, E. M.; Pessoa, L.
10.1101/2022.12.13.520297 — neuroscience — Posted on 2022-12-15
2056 Running ahead of evolution - AI based simulation for predicting future high-risk SARS-CoV-2 variants
Chen, J.; Nie, Z.; Wang, Y.; Wang, K.; Xu, F.; Hu, Z.; Zheng, B.; Wang, Z.; Song, G.; Zhang, J.; Fu, J.; Huang, X.; Wang, Z.; Ren, Z.; Wang, Q.; Li, D.; Wei, D.; Zhou, B.; Yang, C.; Tian, Y.
10.1101/2022.11.17.516989 — bioinformatics — Posted on 2022-12-15
2059 TBC1D15 potentiates lysosomal regeneration from damaged membranes
Bhattacharya, A.; Mukherjee, R.; Kuncha, S. K.; Brunstein, M.; Rathore, R.; Junek, S.; Munch, C.; Dikic, I.
10.1101/2022.12.14.520480 — cell biology — Posted on 2022-12-15
2060 Preclinical development of non-viral gene therapy for patients with advanced pancreatic cancer
Barbey, O.; Lulka, H.; Hanoun, N.; Belhadj, H.; Vernejoul, F.; Cambois, G.; Tiraby, M.; Buscail, L.; Gross, F.; Cordelier, P.
10.1101/2022.12.13.520242 — cancer biology — Posted on 2022-12-15
2061 NAD+ biosynthesis as a collateral lethality target for precision oncology
Muller, F. L.; Deng, P.; Satani, N.; Lin, Y.-H.; Hammoudi, N.; Mohapatra, G.; Asara, J. M.; DePinho, R. A.
10.1101/2022.12.13.518967 — cancer biology — Posted on 2022-12-15
2062 Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair
Martinez Lagunas, K.; Savcigil, D. P.; Zrilic, M.; Carvajal Fraile, C.; Craxton, A.; Self, E.; Uranga, I.; de Miguel, D.; Arias, M.; Willenborg, S.; Piekarek, M.; Albert, M. C.; Nugraha, K.; Lisewski, I.; Janakova, E.; Igual, N.; Tonnus, W.; Hilendbrandt, X.; Ibrahim, M.; Ballegeer, M.; Saelens, X.; Kueh, A. J.; Meier, P.; Linkermann, A.; Pardo, J.; Eming, S.; Walczak, H.; MacFarlane, M.; Peltzer, N.; Annibaldi, A.
10.1101/2022.12.15.520548 — cell biology — Posted on 2022-12-15
2064 Amyloid-PET of the white matter: relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease
Ottoy, J.; Ozzoude, M.; Zukotynski, K.; Kang, M. S.; Adamo, S.; Scott, C.; Ramirez, J.; Swardfager, W.; Lam, B.; Bhan, A.; Mojiri, P.; Kiss, A.; Strother, S.; Bocti, C.; Borrie, M.; Chertkow, H.; Frayne, R.; Hsiung, R.; Laforce, R. J.; Noseworthy, M. D.; Prato, F. S.; Sahlas, D. J.; Smith, E. E.; Kuo, P. H.; Chad, J. A.; Pasternak, O.; Sossi, V.; Thiel, A.; Soucy, J.-P.; Tardif, J.-C.; Black, S. E.; Goubran, M.
10.1101/2021.12.17.473211 — neuroscience — Posted on 2022-12-15
2066 Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing for personalized oncology
Dondi, A.; Lischetti, U.; Jacob, F.; Singer, F.; Borgsmueller, N.; Tumor Profiler Consortium, ; Heinzelmann-Schwarz, V.; Beisel, C.; Beerenwinkel, N.
10.1101/2022.12.12.520051 — cancer biology — Posted on 2022-12-15
2067 Convergent Evolution and B-Cell Recirculation in Germinal Centers in a Human Lymph Node
Pelissier, A.; Stratigopoulou, M.; Donner, N.; Dimitriadis, E.; Bende, R. J.; Guikema, J. E.; Martinez, M. R.; van Noesel, C. J. M.
10.1101/2022.11.09.463832 — evolutionary biology — Posted on 2022-12-15
2068 Proteomics-based determination of double stranded RNA interactome reveals known and new factors involved in Sindbis virus infection
Girardi, E.; Messmer, M.; Lopez, P.; Fender, A.; Chicher, J.; Chane-Woon-Ming, B.; Hammann, P.; Pfeffer, S.
10.1101/2021.03.09.434591 — microbiology — Posted on 2022-12-15
2070 Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG
Crosby, H.; Keim, K. C.; Kwiecinski, J.; Langouët-Astrie, C. J.; Oshima, K.; LaRiviere, W. B.; Schmidt, E. P.; Horswill, A. R.
10.1101/2022.12.13.520364 — microbiology — Posted on 2022-12-15
2071 Blue light promotes ascorbate synthesis by deactivating the PAS/LOV photoreceptor that inhibits GDP-L-galactose phosphorylase
Bournonville, C.; Mori, K.; Blomeier, T.; Mauxion, J.-P.; Jorly, J.; Gadin, S.; Cassan, C.; Maucourt, M.; Just, D.; Bres, C.; Rothan, C.; Ferrand, C.; Fernandez-Lochu, L.; Bataille, L.; Miura, K.; Beven, L.; Zurbriggen, M. D.; Petriacq, P.; Gibon, Y.; Deslous, P.; Decros, G.; Baldet, P.
10.1101/2022.12.12.520143 — plant biology — Posted on 2022-12-15
2074 One thousand soils for molecular understanding of belowground carbon cycling
Bowman, M.; Heath, A. E.; Varga, T.; Battu, A.; Chu, R. K.; Toyoda, J. G.; Cheeke, T.; Porter, S.; Moffett, K.; Letendre, B.; Qafoku, O.; Bargar, J.; Mans, D.; Hess, N.; Graham, E. B.
10.1101/2022.12.12.520098 — ecology — Posted on 2022-12-15
2075 COVID-19 Associated Pulmonary Aspergillosis isolates are genomically diverse but similar to each other in their responses to infection-relevant stresses
Mead, M. E.; Alves de Castro, P.; Steenwyk, J. B.; Gangneux, J.-P.; Hoenigl, M.; Prattes, J.; Rautemaa-Richardson, R.; Guegan, H.; Moore, C. B.; Lass-Floerl, C.; Reizine, F.; Valero, C.; van Rhijn, N.; Bromley, M. J.; Rokas, A.; Goldman, G. H.; Gago, S.
10.1101/2022.12.14.520265 — cell biology — Posted on 2022-12-15
2079 A transcriptome atlas of Striga hermonthica germination
Irafasha, G.; Mutinda, S.; Maati, F. M.; Hale, B.; Omwenga, G.; Wijeratne, A.; Wicke, S.; Bellis, E.; Runo, S.
10.1101/2022.12.14.520245 — plant biology — Posted on 2022-12-15
2080 Fern cell walls and the evolution of arabinogalactan-proteins in streptophytes
Mueller, K.-K.; Pfeifer, L.; Schuldt, L.; Szoevenyi, P.; de Vries, S.; de Vries, J.; Johnson, K. L.; Classen, B.
10.1101/2022.12.15.520549 — plant biology — Posted on 2022-12-15
2081 miR472 deficiency enhances Arabidopsis thaliana defence without reducing seed production.
Vasseur, F.; Baldrich, P.; Jimenez-Gongora, T.; Villar-Martin, L.; Weigel, D.; Rubio-Somoza, I.
10.1101/2022.12.13.520224 — plant biology — Posted on 2022-12-15
2083 Quantifying physiological trait variation with automated hyperspectral imaging in rice
Ting, T.-C.; Souza, A.; Imel, R.; Guadagno, C. R.; Hoagland, C.; Yang, Y.; Wang, D. R.
10.1101/2022.12.14.520506 — plant biology — Posted on 2022-12-15
2084 Apoplast-localized β-Glucosidase Elevates Isoflavone Accumulation in the Soybean Rhizosphere
Matsuda, H.; Yamazaki, Y.; Moriyoshi, E.; Nakayasu, M.; Yamazaki, S.; Aoki, Y.; Takase, H.; Okazaki, S.; Nagano, A. J.; Kaga, A.; Yazaki, K.; Sugiyama, A.
10.1101/2022.12.13.520340 — plant biology — Posted on 2022-12-15
2088 A dedicated hypothalamic oxytocin circuit controls aversive social learning
Osakada, T.; Yan, R.; Jiang, Y.; Wei, D.; Tabuchi, R.; Dai, B.; Wang, X.; Zhao, G.; Wang, C. X.; Tsien, R. W.; Mar, A. C.; Lin, D.
10.1101/2022.12.14.519639 — neuroscience — Posted on 2022-12-15
2089 Network topology in brain tumor patients with and without structural epilepsy- a prospective MEG-study
Ladisich, B.; Rampp, S.; Trinka, E.; Weisz, N.; Schwartz, C.; Kraus, T.; Sherif, C.; Marhold, F.; Demarchi, G.
10.1101/2022.12.01.518725 — neuroscience — Posted on 2022-12-15
2090 SpliceAI-10k calculator for the prediction of pseudoexonization, intron retention, and exon deletion
Canson, D. M.; Davidson, A. L.; de la Hoya, M.; Parsons, M. T.; Glubb, D. M.; Kondrashova, O. M.; Spurdle, A. B.
10.1101/2022.07.30.502132 — bioinformatics — Posted on 2022-12-15
2091 Early suppression of excitability in subcortical band heterotopia modifies epileptogenesis in rats
Hardy, D.; Buhler, E.; Suchkov, D.; Vinck, A.; Fortoul, A.; Watrin, F.; Represa, A.; Minlebaev, M.; Manent, J.-B.
10.1101/2022.09.06.506850 — neuroscience — Posted on 2022-12-15
2093 Molecular mechanism of substrate recognition by folate transporter SLC19A1
Dang, Y.; Zhou, D.; Du, X.; Zhao, H.; Lee, C.-H.; Yang, J.; Wang, Y.; Qin, C.; Guo, Z.; Zhang, Z.
10.1101/2022.09.09.507238 — biochemistry — Posted on 2022-12-14
2094 Signaling Node at TSC2 S1365 Potently Regulates T-Cell Differentiation and Improves Adoptive Cellular Cancer Therapy
Kass, D. A.; Powell, J. D.; Patel, C.; Dong, Y.; Dunkerly-Eyring, B. L.; Wen, J.; Ranek, M. J.; Bartle, L. M.; Henderson, D. B.; Sagert, J.
10.1101/2022.11.30.518569 — immunology — Posted on 2022-12-14
2096 Identification of functional immune and neuronal tumor cells in glioma
Curry, R. N.; McDonald, M. F.; Ma, Q.; Meyer, J.; Aiba, I.; Lozzi, B.; Cervantes, A.; Ko, Y.; Luna-Figueroa, E.; Choi, D.-J.; Lee, Z.-F.; Jing, J.; Harmanci, A. O.; Rosenbaum, A.; He, P.; Mohila, C.; Jalali, A.; Noebels, J.; Jiang, X.; Deneen, B.; Rao, G.; Serin Harmanci, A.
10.1101/2022.11.05.515316 — cancer biology — Posted on 2022-12-14
2101 De novo design of high-affinity protein binders to bioactive helical peptides
Vazquez Torres, S.; Leung, P. J. Y.; Lutz, I. D.; Venkatesh, P.; Watson, J. L.; Hink, F.; Huynh, H.-H.; Yeh, A. H.-W.; Juergens, D.; Bennett, N. R.; Hoofnagle, A. N.; Huang, E.; MacCoss, M. J.; Exposit, M.; Lee, G. R.; Levine, P. M.; Li, X.; Lamb, M.; Korkmaz, E. N.; Nivala, J.; Stewart, L.; Rogers, J. M.; Baker, D.
10.1101/2022.12.10.519862 — bioengineering — Posted on 2022-12-14
2102 Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models
Watson, J. L.; Juergens, D.; Bennett, N. R.; Trippe, B. L.; Yim, J.; Eisenach, H. E.; Ahern, W.; Borst, A. J.; Ragotte, R. J.; Milles, L. F.; Wicky, B. I. M.; Hanikel, N.; Pellock, S. J.; Courbet, A.; Sheffler, W.; Wang, J.; Venkatesh, P.; Sappington, I.; Vazquez Torres, S.; Lauko, A.; De Bortoli, V.; Mathieu, E.; Barzilay, R.; Jaakkola, T. S.; DiMaio, F.; Baek, M.; Baker, D.
10.1101/2022.12.09.519842 — biochemistry — Posted on 2022-12-14
2106 An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion
Noordstra, I.; Diez Hermoso, M.; Schimmel, L.; Bonfim-Melo, A.; Currin-Ross, D.; Duong, C. N.; Kalappurakkal, J. M.; Morris, R. G.; Vestweber, D.; Mayor, S.; Gordon, E.; Roca-Cusachs, P.; Yap, A. S.
10.1101/2021.07.28.454239 — cell biology — Posted on 2022-12-14
2109 EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry
Luan, H.; Bielecki, T. A.; Mohapatra, B. C.; Islam, N.; Mushtaq, I.; Bhat, A. M.; Mirza, S.; Chakraborty, S.; Raza, M.; Storck, M. D.; Toss, M. S.; Meza, J. L.; Thoreson, W. B.; Coulter, D. W.; Rakha, E.; Band, V.; Band, H.
10.1101/2022.06.21.497035 — cancer biology — Posted on 2022-12-14
2111 Evaluation of a scalable approach to generate cell-type specific transcriptomic profiles of mesenchymal lineage cells
Dillard, L. J.; Rosenow, W. T.; Calabrese, G. M.; Mesner, L. D.; Al-Barghouthi, B. M.; Abood, A.; Farber, E. A.; Onengut-Gumuscu, S.; Tommasini, S. M.; Horowitz, M. A.; Rosen, C. J.; Yao, L.; Qin, L.; Farber, C. R.
10.1101/2022.12.13.520148 — bioinformatics — Posted on 2022-12-14
2112 Engineering Antioxidant and Oxygen-Releasing Lignin Composites to Promote Wound Healing
Balaji, S.; Short, W. D.; Padon, B. W.; Belgodere, J. A.; Jimenez, S. E.; Deoli, N. T.; Guidry, A. C.; Green, J. C.; Prajapati, T. J.; Farouk, F.; Kaul, A.; Son, D.; Jung, O. S.; Astete, C. E.; Kim, M.; Jung, J. P.
10.1101/2022.03.18.484913 — bioengineering — Posted on 2022-12-14
2113 Novel exotic alleles of EARLY FLOWERING 3 determine plant development in barley
Zahn, T.; Zhu, Z.; Ritoff, N.; Krapf, J.; Junker, A.; Altmann, T.; Schmutzer, T.; Tüting, C.; Kastritis, P. L.; Babben, S.; Quint, M.; Pillen, K.; Maurer, A.
10.1101/2022.07.15.500212 — genetics — Posted on 2022-12-14
2114 Assessing risk for butterflies in the context of climate change, demographic uncertainty, and heterogenous data sources
Forister, M. L.; Grames, E. M.; Halsch, C. A.; Burls, K. J.; Carroll, C. F.; Bell, K. L.; Jahner, J. P.; Bradford, T.; Zhang, J.; Cong, Q.; Grishin, N. V.; Glassberg, J.; Shapiro, A. M.; Riecke, T. V.
10.1101/2022.05.22.492972 — ecology — Posted on 2022-12-14
2115 Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome
Shin, H.; Leung, A.; Costello, K. R.; Senapati, P.; Kato, H.; Lee, M.; Lin, D.; Tang, X.; Chen, Z. B.; Schones, D. E.
10.1101/2022.05.11.491514 — molecular biology — Posted on 2022-12-14
2117 Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy
Khan, A. A.; Langston, H. C.; Walsh, L.; Roscoe, R.; Jayawardhana, S.; Francisco, A. F.; Taylor, M. C.; McCann, C. J.; Kelly, J. M.; Lewis, M. D.
10.1101/2022.12.14.520395 — microbiology — Posted on 2022-12-14
2120 Cellular and Circuit Organization of the Locus Coeruleus of Adult Mice
McKinney, A.; Hu, M.; Jing, J.; Hoskins, A.; Mohammadyar, A.; Naeem, N.; Patel, S.; Sheth, B. R.; Jiang, X.
10.1101/2022.03.01.481656 — neuroscience — Posted on 2022-12-14
2122 The TRPV Channel OSM-9 is Required for Sleep-Dependent Olfactory Memory and is Expressed in Sensory Neurons That Typically Do Not Promote Butanone Attraction
Benedetti, K. L.; Saifuddin, F. A.; Miller, J. M.; Daigle, K.; Chandra, R.; Chen, A.; Lin, C.; Garcia, A. J.; Calcuttawala, B.; Tovar, A.; Dunn, R. L.; Borchardt, J.; Kaye, J. A.; Zhang, B.; Kato, S.; Gallegos, M. E.; Wittmann, T.; L'Etoile, N.
10.1101/2020.11.27.400747 — neuroscience — Posted on 2022-12-14
2124 A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation
Ge, A. Y.; Arab, A.; Dai, R.; Navickas, A.; Fish, L.; Garcia, K.; Asgharian, H.; Goodarzi, H.; Gilbert, L.
10.1101/2022.12.14.518457 — cancer biology — Posted on 2022-12-14
2125 Reordering of aromatic-rich segments in FUS inhibits ageing of FUS-RNA condensates
Blazquez, S.; Sanchez-Burgos, I.; Ramirez, J.; Higginbotham, T.; Conde, M. M.; Collepardo-Guevara, R.; Tejedor, A. R.; Espinosa, J. R.
10.1101/2022.12.14.520383 — biophysics — Posted on 2022-12-14
2129 Next-generation plasmids for transgenesis in zebrafish and beyond
Kemmler, C. L.; Moran, H. R.; Murray, B. F.; Scoresby, A.; Klem, J. R.; Eckert, R. L.; Lepovsky, E.; Bertho, S.; Nieuwenhuize, S.; Burger, S.; D'Agati, G.; Betz, C.; Puller, A.-C.; Felker, A.; Ditrychova, K.; Boetschi, S.; Affolter, M.; Rohner, N.; Lovely, C. B.; Kwan, K. M.; Burger, A.; Mosimann, C.
10.1101/2022.12.13.520107 — genetics — Posted on 2022-12-14
2130 Rapid detection of DNA and RNA shrimp viruses using CRISPR-based diagnostics
Major, S. R.; Harke, M. J.; Dhar, A. K.; Cruz-Flores, R.; Bodnar, A. G.; Trigg, S. A.
10.1101/2022.12.14.520450 — molecular biology — Posted on 2022-12-14
2132 Effects of DNA extraction, DNA integrity, and laboratory on the precision of qPCR-based telomere length measurement - a multi-lab impartial study
Lin, J.; Verhulst, S.; Fernandez Alonso, C.; Dagnall, C.; Gadalla, S.; Hastings, W.; Lai, T.-P.; Zheng, Y.-L.; Wang, Y.; Shalev, I.; Epel, E.; Drury, S.
10.1101/2022.12.14.520438 — molecular biology — Posted on 2022-12-14
2133 Chaotic signatures in host-microbe interactions
Sella, Y.; Broderick, N. A.; Stouffer, K.; McEwan, D. L.; Ausubel, F. M.; Casadevall, A.; Bergman, A.
10.1101/2022.12.14.520402 — microbiology — Posted on 2022-12-14
2135 Exploring Viral Communities Associated With Terrestrial Cyanobacteria Metagenomes
Ettinger, C. L.; Paul, S. R.; Flores, N.; Ward, R. D.; Pietrasiak, N.; Stajich, J. E.
10.1101/2022.12.14.520320 — microbiology — Posted on 2022-12-14
2137 Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis
Hendricks, J. M.; Doubravsky, C.; Wehri, E.; Li, Z.; Roberts, M. A.; Deol, K.; Lange, M.; Lasheras-Otero, I.; Dixon, S. J.; Bersuker, K.; Schaletzky, J.; Olzmann, J. A.
10.1101/2022.12.14.520445 — cancer biology — Posted on 2022-12-14
2139 Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening
Kim, S. H.; Shin, S.; Baek, M.; Xiong, K.; Karottki, K. J. l. C.; Hefzi, H.; Grav, L. M.; Pedersen, L. E.; Kildegaard, H. F.; Lewis, N. E.; Lee, J. S.; Lee, G. M.
10.1101/2022.12.13.520335 — bioengineering — Posted on 2022-12-14
2140 Polyacrylamide-based Hydrogel Coatings Improve Biocompatibility of Implanted Pump Devices
Chan, D.; Maikawa, C. L.; d'Aquino, A. I.; Raghavan, S. S.; Troxell, M. L.; Appel, E. A.
10.1101/2022.12.13.520347 — bioengineering — Posted on 2022-12-14
2141 SPNS1 is required for the transport of lysosphingolipids and lysoglycerophospholipids from lysosomes
Ha, H. T. T.; Nguyen, X. T. A.; Vo, L. K.; Leong, N. C. P.; Liu, S.; Nguyen, D. T.; Lim, Y. P.; Wu, J. Y.; Nguyen, T. Q.; Oh, J.; Wenk, M. R.; Cazenave-Gassiot, A.; Ong, Y. W.; Nguyen, L. N.
10.1101/2022.12.14.520377 — biochemistry — Posted on 2022-12-14
2142 Genetic diversity landscapes in outcrossing and selfing Caenorhabditis nematodes
Teterina, A. A.; Willis, J. H.; Lukac, M.; Jovelin, R.; Cutter, A. D.; Phillips, P. C.
10.1101/2022.12.13.520296 — evolutionary biology — Posted on 2022-12-14
2146 Peroxiredoxin 2 is required for the redox mediated adaptation to exercise
Xia, Q.; Casas-Martinez, J. C.; Zarzuela, E.; Munoz, J.; Miranda-Vizuete, A.; Goljanek-Whysall, K.; McDonagh, B.
10.1101/2022.12.14.520384 — molecular biology — Posted on 2022-12-14
2147 DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.
Brouze, M.; Szpila, M.; Czerwinska, A. M.; Antczak, W.; Mroczek, S.; Kulinski, T. M.; Hojka-Osinska, A. M.; Cysewski, D.; Adamska, D.; Gruchota, J.; Borsuk, E.; Dziembowski, A.
10.1101/2022.12.14.520403 — molecular biology — Posted on 2022-12-14
2148 Pantothenate auxotrophy in a naturally occurring biocontrol yeast
Rueda Mejia, M. P.; Ortiz-Merino, R. A.; Lutz, S.; Ahrens, C. H.; Kuenzler, M.; Freimoser, F. M.
10.1101/2022.12.14.519733 — microbiology — Posted on 2022-12-14
2150 Recruitment of TRiC chaperonin in rotavirus viroplasms directly associates with virus replication.
Vetter, J.; Papa, G.; Tobler, K.; Kley, M.; Myers, M.; Wiesendanger, M.; Schraner, E. M.; Burrone, O. R.; Fraefel, C.; Eichwald, C.
10.1101/2022.12.13.520363 — microbiology — Posted on 2022-12-14
2153 Deciphering the determinants of recombinant protein yield across the human secretome
Masson, H. O.; Kuo, C.-C.; Malm, M.; Lundqvist, M.; Sivertsson, A.; Berling, A.; Tegel, H.; Hober, S.; Uhlen, M.; Grassi, L.; Hatton, D.; Rockberg, J.; Lewis, N. E.
10.1101/2022.12.12.520152 — systems biology — Posted on 2022-12-14
2155 Application of Aligned-UMAP to longitudinal biomedical studies
Dadu, A.; Satone, V. K.; Kaur, R.; Koretsky, M. J.; Iwaki, H.; Qi, Y. A.; Ramos, D. M.; Avants, B.; Hesterman, J.; Gunn, R.; Cookson, M. R.; Ward, M. E.; Singleton, A.; Campbell, R.; Nalls, M. A.; Faghri, F.
10.1101/2022.12.12.518225 — bioinformatics — Posted on 2022-12-14
2160 Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells
Yamaya, K.; Wang, B.; Memar, N.; Woglar, A.; Odiba, A. S.; Gartner, A.; Villeneuve, A. M.
10.1101/2022.12.12.520157 — genetics — Posted on 2022-12-14
2165 A comparison of survey method efficiency for estimating densities of Zebra Mussels (Dreissena polymorpha)
Ferguson, J. M.; Jimenez, L.; Keyes, A. A.; Hilding, A.; McCartney, M. A.; St Clair, K.; Johnson, D. H.; Fieberg, J.
10.1101/2022.12.12.520173 — ecology — Posted on 2022-12-14
2166 The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice
Guan, Y.; Gao, H.; Leu, N. A.; Vourekas, A.; Alexiou, P.; Maragkakis, M.; Mourelatos, Z.; Liang, G.; Wang, P. J.
10.1101/2022.12.13.520206 — developmental biology — Posted on 2022-12-14
2170 Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia
Kim, Y.-M.; Sanborn, M. A.; Wang, X.; Mancinelli, G.; Chakraborty, S.; Vijeth, S.; Gajwani, P.; Grippo, P.; Lee, S. S.-Y.; Valyi-Nagy, T.; Toth, P. T.; Valyi-Nagy, K.; Rehman, J.
10.1101/2022.12.12.520118 — cancer biology — Posted on 2022-12-14
2172 Quantifying B-cell Clonal Diversity In Repertoire Data
Pelissier, A.; Luo, S.; Stratigopoulou, M.; Guikema, J.; Rodriguez Martinez, M.
10.1101/2022.12.12.520133 — bioinformatics — Posted on 2022-12-14
2173 Mass Dynamics 2.0: An improved modular web-based platform for accelerated proteomics insight generation and decision making
Quaglieri, A.; Bloom, J.; Triantafyllidis, A.; Green, B.; Condina, M. R.; Burton Ngov, P.; Infusini, G.; Webb, A. I.
10.1101/2022.12.12.517480 — bioinformatics — Posted on 2022-12-14
2174 Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals significant contamination with NUMTs, and challenges predominantly purifying selection in late PGCs
Fleischmann, Z.; Cote-LHeureux, A.; Franco, M.; Oreshkov, S.; Annis, S.; Khrapko, M.; Aidlen, D.; Popadin, K.; Woods, D. C.; Tilly, J. L.; Khrapko, K.
10.1101/2022.12.12.520138 — genomics — Posted on 2022-12-14
2179 Transcriptomic profiling reveals distinct subsets of immune checkpoint inhibitor-induced myositis
Pinal-Fernandez, I.; Quintana, A.; Milisenda, J.; Casal-Dominguez, M.; Munoz-Braceras, S.; Derfoul, A.; Torres-Ruiz, J.; Pak, K.; Del Orso, S.; Naz, F.; Gutierrez-Cruz, G.; Milone, M.; Shelly, S.; Duque-Jaimez, Y.; Tobias-Baraja, E.; Matas-Garcia, A.; Garrabou, G.; Padrosa, J.; Ros, J.; Trallero-Araguas, E.; Walitt, B.; Christopher-Stine, L.; Lloyd, T. E.; Zhao, C.; Swift, S.; Rajan, A.; Grau, J. M.; Selva-O'Callaghan, A.; Liewluck, T.; Mammen, A. L.
10.1101/2022.12.12.520136 — immunology — Posted on 2022-12-14
2180 Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine
Janganati, V.; Salazar, P.; Parks, B. J.; Gorman, G. S.; Prather, P. L.; Crooks, P. A.; Brents, L. K.
10.1101/2022.12.12.520120 — pharmacology and toxicology — Posted on 2022-12-14
2183 Ultrafast molecular dynamics observed within a dense protein condensate
Galvanetto, N.; Ivanovic, M. T.; Chowdhury, A.; Sottini, A.; Nüesch, M.; Nettels, D.; Best, R.; Schuler, B.
10.1101/2022.12.12.520135 — biophysics — Posted on 2022-12-14
2184 Enhancing detectable fluorescence fluctuation for high-throughput and four-dimensional live-cell super-resolution imaging
Zhao, W.; Zhao, S.; Han, Z.; Ding, X.; Hu, G.; Wang, X.; Mao, H.; Jiu, Y.; Hu, Y.; Tan, J.; Ding, X.; Guo, C.; Chen, L.; Li, H.
10.1101/2022.12.12.520072 — biophysics — Posted on 2022-12-14
2185 GENERALIST: An efficient generative model for protein sequence families
Akl, H.; Emison, B.; Zhao, X.; Mondal, A.; Perez, A.; Dixit, P. D.
10.1101/2022.12.12.520114 — biophysics — Posted on 2022-12-14
2195 Lacustrine speciation associated with chromosomal inversion in a lineage of riverine fishes
MacGuigan, D. J.; Krabbenhoft, T. J.; Harrington, R. C.; Wainwright, D. K.; Backenstose, N. J. C.; Near, T. J.
10.1101/2022.12.12.519811 — evolutionary biology — Posted on 2022-12-14
2199 Genetic analysis of the rice jasmonate receptors reveals specialized function for OsCOI2
Nguyen, H. T.; Cheaib, M.; Fournel, M.; Rios, M.; Gantet, P.; Laplaze, L.; Guyomarch, S.; Riemann, M.; Heitz, T.; Petitot, A.-S.; Champion, A.
10.1101/2022.12.12.520024 — plant biology — Posted on 2022-12-14
2200 MicroRNA397 regulates tolerance to drought and fungal infection by regulating lignin deposition in chickpea root
Sharma, N. K.; Gupta, S. K.; Irrulappan, V. K.; Yadav, S.; Francis, A.; Senthil-Kumar, M.; Chattopadhyay, D.
10.1101/2022.12.12.520062 — plant biology — Posted on 2022-12-14
2201 Mycorrhizal status impacts the genetic architecture of mineral accumulation in field grown maize (Zea mays ssp. mays L.)
Li, M.; Perez-Limon, S.; Ramirez-Flores, M. R.; Barrales-Gamez, B.; Meraz-Mercado, M. A.; Ziegler, G.; Baxter, I.; Olalde-Portugal, V.; Sawers, R. J.
10.1101/2022.12.12.520122 — plant biology — Posted on 2022-12-14
2206 2-Thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses
Uemura, K.; Nobori, H.; Sato, A.; Toba, S.; Kusakabe, S.; Sasaki, M.; Tabata, K.; Matsuno, K.; Maeda, N.; Ito, S.; Tanaka, M.; Anraku, Y.; Kita, S.; Ishii, M.; Kanamitsu, K.; Orba, Y.; Matsuura, Y.; Hall, W. W.; Sawa, H.; Kida, H.; Matsuda, A.; Maenaka, K.
10.1101/2022.12.14.520006 — microbiology — Posted on 2022-12-14
2208 Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing for personalized oncology
Dondi, A.; Lischetti, U.; Jacob, F.; Singer, F.; Borgsmueller, N.; Tumor Profiler Consortium, ; Heinzelmann-Schwarz, V.; Beisel, C.; Beerenwinkel, N.
10.1101/2022.12.12.520051 — cancer biology — Posted on 2022-12-14
2209 Pan-cancer transcriptomic analysis reveals a tissue-specific loss of identity
dos Santos, G. A.; Chatsirisupachai, K.; Avelar, R.; de Magalhaes, J. P.
10.1101/2022.12.12.520045 — bioinformatics — Posted on 2022-12-14
2210 Genome-wide analysis of dry (Tamar) Date palm fruit color
Younuskunju, S.; Mohamoud, Y. A.; Mathew, L. S.; Mayer, K. F. X.; Suhre, K.; Malek, J. A.
10.1101/2022.12.12.520041 — bioinformatics — Posted on 2022-12-14
2211 Sfrp2 is a multifunctional regulator of rodent color patterns
Johnson, M. R.; Li, S.; Guerrero-Juarez, C. F.; Miller, P.; Brack, B. J.; Mereby, S.; Feigin, C. Y.; Gaska, J.; Ploss, A.; Nie, Q.; Rivera-Perez, J. A.; Shvartsman, S. Y.; Mallarino, R.
10.1101/2022.12.12.520043 — developmental biology — Posted on 2022-12-14
2212 Differentiation of leukocytes in bronchoalveolar lavage fluid samples using higher harmonic generation microscopy and deep learning
van Huizen, L. M. G.; Blokker, M.; Rip, Y.; Veta, M.; Mooij - Kalverda, K. A.; Bonta, P. I.; Duitman, J. W. W.; Groot, M. L.
10.1101/2022.12.12.520069 — immunology — Posted on 2022-12-14
2214 Distinct Subsets of Multi-Lymphoid Progenitors Support Ontogeny-Related Changes in Human Lymphopoiesis
Keita, S.; Diop, S.; Lekiashvili, S.; Chabaane, E.; Nelson, E.; Strullu, M.; Arfeuille, C.; Guimiot, F.; Domet, T.; Duchez, S.; Evrard, B.; Darde, T.; Larghero, J.; Verhoeyen, E.; Cumano, A.; Macintyre, E. A.; Jouen, F.; Goodhardt, M.; Garrick, D.; Chalmel, F.; Alhaj Hussen, K.; CANQUE, B.
10.1101/2022.12.12.520060 — immunology — Posted on 2022-12-14
2215 Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant-pathogen interface
Sueldo, D.; Godson, A.; Kaschani, F.; Krahn, D.; Kessenbrock, T.; Buscaill, P.; Schofield, C. J.; Kaiser, M.; van der Hoorn, R. A. L.
10.1101/2022.12.12.520059 — plant biology — Posted on 2022-12-14
2216 Reimagining Gene-Environment Interaction Analysis for Human Complex Traits
Miao, J.; Song, G.; Wu, Y.; Hu, J.; Wu, Y.; Basu, S.; Andrews, J. S.; Schaumberg, K.; Fletcher, J. M.; Schmitz, L. L.; Lu, Q.
10.1101/2022.12.11.519973 — genetics — Posted on 2022-12-14
2217 Absence of the bile acid enzyme CYP8B1 increases brain chenodeoxycholic acid and reduces neuronal excitotoxicity in mice
Monteiro-Cardoso, V. F.; Yeo, X. Y.; Bae, H.-G.; Castano Mayan, D.; Wehbe, M.; Lee, S.; Krishna-K, K.; Baek, S. H.; Palomera, L. F.; Shanmugam, S.; Sem, K. P.; Parsons, M. P.; Hayden, M. R.; Liehn, E. A.; Sajikumar, S.; Davanger, S.; Jo, D.-G.; Jung, S.; Singaraja, R. R.
10.1101/2022.12.11.520005 — physiology — Posted on 2022-12-14
2220 FrustraPocket: A protein-ligand binding site predictor using energetic local frustration
Freiberger, M. I.; Clemente, C. M.; Valero, E.; Pombo, J. G.; Leonetti, C. O.; Ravetti, S.; Parra, R. G.; Ferreiro, D. U.
10.1101/2022.12.11.519349 — bioinformatics — Posted on 2022-12-14
2221 The Structural Layers of the Porcine Iris Exhibit Inherently Different Biomechanical Properties
Tan, R. K. Y.; Panda, S. K.; Braeu, F. A.; Muralidharan, A. R.; Nongpiur, M. E.; Chan, A. S. Y.; Aung, T.; Najjar, R. P.; Girard, M. J. A.
10.1101/2022.12.11.519999 — bioengineering — Posted on 2022-12-14
2226 Transcriptomic landscape and potential therapeutic targets for human testicular aging revealed by single-cell RNA sequencing
Xia, K.; He, S.; Luo, P.; Dong, L.; Gao, F.; Chen, X.; Ye, Y.; Gao, Y.; Ma, Y.; Zhang, Y.; Yang, Q.; Han, D.; Feng, X.; Wan, Z.; Cai, H.; Ke, Q.; Wang, T.; Li, W.; Tu, X.; Sun, X.; Deng, C.; Peng Xiang, A.
10.1101/2022.12.11.519976 — developmental biology — Posted on 2022-12-14
2227 Global and cell type-specific immunological hallmarks of severe dengue progression
Ghita, L.; Yao, Z.; Xie, Y.; Duran, V.; Cagirici, B. H.; Samir, J.; Osman, I.; Agudelo, O. L.; Sanz, A. M.; Sahoo, M. K.; Robinson, M.; Gelvez, R. M.; Bueno, N.; Luciani, F.; Pinsky, B. A.; Montoya, J. G.; Estupinan Cardenas, M. I.; Villar, L. A.; Rojas Garrido, E. M.; Rosso, F.; Quake, S. R.; Zanini, F.; Einav, S.
10.1101/2022.12.11.519930 — immunology — Posted on 2022-12-14
2228 D1RCaMKII in claustrum mediates ACE-induced anxiety and electro-acupuncture therapy
Chen, L.; Liu, Z.; Zhao, Z.; Guo, H.; Du, D.; Pan, W.; Wei, X.; Nie, J.; Ge, F.; Ding, J.; Fan, Y.; Kim, H. Y.; Guan, X.
10.1101/2022.10.18.512685 — neuroscience — Posted on 2022-12-14
2230 Combined in vivo and in situ genome-resolved metagenomics reveals novel symbiotic nitrogen fixing interactions between non-cyanobacterial diazotrophs and microalgae
Chandola, U.; Trottier, C.; Gaudin, M.; Manirakiza, E.; Menicot, S.; Louvet, I.; Lacour, T.; Chaumier, T.; Tanaka, A.; Chaffron, S.; Tirichine, L.
10.1101/2022.08.25.505241 — microbiology — Posted on 2022-12-14
2232 Direction mutation pressure of SARS-CoV-2 helps to understand the past and predict the future evolution: C>U and G>U biased mutagenesis forces the majority of amino-acid substitutions to be from CG-rich losers to U-rich gainers
Voronka, A.; Efimenko, B.; Oreshkov, S.; Franco, M.; Fleischmann, Z.; Yurov, V.; Trufanova, A.; Timonina, V.; Ree, N.; Zalevsky, A.; Penfrat, E.; Junier, T.; Agranovsky, A.; Khrapko, K.; Gunbin, K.; Fellay, J.; Popadin, K.
10.1101/2022.08.22.504819 — evolutionary biology — Posted on 2022-12-14
2233 Shift of the insoluble content of the proteome in aging mouse brain
Molzahn, C. M.; Kuechler, E. R.; Zemlyankina, I.; Nieves, L.; Ali, T.; Cole, G.; Wang, J.; Albu, R. F.; Zhu, M.; Cashman, N.; Gilch, S.; Karsan, A.; Lange, P. F.; Gsponer, J.; Mayor, T.
10.1101/2022.12.13.520290 — cell biology — Posted on 2022-12-14
2235 An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity
Ader, N. R.; Chen, L.; Surovtsev, I. V.; Chadwick, W. L.; King, M. C.; Lusk, C. P.
10.1101/2022.12.12.520126 — cell biology — Posted on 2022-12-14
2237 Inhibition of early-acting autophagy genes in C. elegans neurons improves protein homeostasis, promotes exopher production, and extends lifespan via the ATG-16.2 WD40 domain
Yang, Y.; Arnold, M. L.; Choy, E. H.; Lange, C. M.; Poon, K.; Broussalian, M.; Sun, L.-H.; Moreno, T. M.; Singh, A.; Driscoll, M.; Kumsta, C.; Hansen, M.
10.1101/2022.12.12.520171 — cell biology — Posted on 2022-12-14
2238 Merlin-deficient iPSCs show altered pluripotency and constitute a potential in vitro model for NF2-related schwannomas
Catasus, N.; Torres-Martin, M.; Negro, A.; Kuebler, B.; Rosas, I.; Casals, G.; Mazuelas, H.; Roca-Ribas, F.; Amilibia, E.; Aran, B.; Veiga, A.; Raya, A.; Gel Moreno, B.; Blanco, I.; Serra, E.; Carrio, M.; CASTELLANOS, E.
10.1101/2022.12.14.520389 — cell biology — Posted on 2022-12-14
2240 Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model
Patel, D. R.; Minns, A. M.; Sims, D. G.; Field, C. J.; Kerr, A. E.; Heinly, T.; Luley, E. H.; Rossi, R. M.; Bator, C.; Mostafa, I. M.; Hafenstein, S. L.; Lindner, S. E.; Sutton, T. C.
10.1101/2022.10.27.514054 — immunology — Posted on 2022-12-14
2241 Deep learning-based automated lesion segmentation on mouse stroke magnetic resonance images
An, J.; Wendt, L.; Wiese, G.; Herold, T.; Rzepka, N.; Mueller, S.; Koch, S. P.; Hoffmann, C. J.; Harms, C.; Boehm-Sturm, P.
10.1101/2022.08.09.503140 — neuroscience — Posted on 2022-12-14
2242 Bias in group-level EEG microstate analysis
Murphy, M.; Wang, J.; Jiang, C.; Wang, L.; Kozhemiako, N.; Wang, Y.; GRINS Consortium, ; Pan, J. Q.; Purcell, S. M.
10.1101/2022.11.07.515464 — neuroscience — Posted on 2022-12-14
2244 A conserved Plasmodium protein that localizes to liver stage nuclei is critical for late liver stage development.
Goswami, D.; Arredondo, S. A.; Betz, W.; Armstrong, J.; Oualim, K. M. Z.; Seilie, A. M.; Murphy, S. C.; Kappe, S. H. I.; Vaughan, A. M.
10.1101/2022.12.13.519845 — cell biology — Posted on 2022-12-14
2249 Chromosome 8 gain drives poor patient outcome via expression of 4E-BP1 in Ewing sarcoma
Funk, C. M.; Orth, M. F.; Aljakouch, K.; Ehlers, A.; Li, J.; Hoelting, T. L. B.; Will, R.; Willis, F.; Vinca, E.; Ohmura, S.; Imle, R.; Knott, M. M. L.; Zahnow, F.; Sastre, A.; Alonso, J.; Sahm, F.; Schneider, M.; Banito, A.; Leprivier, G.; Hartmann, W.; Dirksen, U.; Witt, O.; Oehme, I.; Pfister, S. M.; Romero-Perez, L.; Krijgsveld, J.; Cidre-Aranaz, F.; Gruenewald, T. G. P.; Musa, J.
10.1101/2022.12.11.519935 — cancer biology — Posted on 2022-12-14
2250 SARS-CoV-2 vaccine-breakthrough infections (VBIs) by Omicron (B.1.1.529) variant and consequences in structural and functional impact
Abduljaleel, Z.; Melebari, S.; Dehlawi, S.; Kumar S, U.; Aziz, S. A.; Dannoun, A. I.; Malik, S. M.; Doss C, G. P.
10.1101/2022.12.12.520021 — molecular biology — Posted on 2022-12-14
2251 Single-cell dynamics of core pluripotency factors in human pluripotent stem cells
Mihailovic, S.; Wolff, S. C.; Kedziora, K. M.; Smiddy, N. M.; Redick, M. A.; Wang, Y.; Lin, G. K.; Zikry, T. M.; Simon, J.; Ptacek, T.; Allbritton, N. L.; Beltran, A. S.; Purvis, J. E.
10.1101/2022.12.13.520282 — developmental biology — Posted on 2022-12-14
2252 A cell atlas of human adrenal cortex development and disease
del Valle, I.; Young, M. D.; Kildisiute, G.; Ogunbiyi, O. K.; Simcock, I. C.; Khabirova, E.; Buonocore, F.; Crespo, B.; Moreno, N.; Brooks, T.; Niola, P.; Swarbrick, K.; Suntharalingham, J. P.; McGlacken-Bryne, S. M.; Arthurs, O. J.; Behjati, S.; Achermann, J. C.
10.1101/2022.12.13.520231 — developmental biology — Posted on 2022-12-14
2254 A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy
Gross, A.; Ghillebert, R.; Schuetter, M.; Reinartz, E.; Rowland, A.; Graef, M.
10.1101/2022.12.13.520293 — cell biology — Posted on 2022-12-14
2256 Combinatorial assembly and design of enzymes
Lipsh-Sokolik, R.; Khersonsky, O.; Schroder, S. P.; de Boer, C.; Hoch, S. Y.; Davies, G. J.; Overkleeft, H. S.; Fleishman, S. J.
10.1101/2022.09.17.508230 — bioengineering — Posted on 2022-12-14
2262 Type I PRMT inhibitor MS023 promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue the phenotype of SMA mice
Kordala, A. J.; Ahlskog, N.; Hanifi, M.; Bhomra, A.; Stoodley, J.; Lim, W. F.; Hammond, S.; Wood, M. J.; Rinaldi, C.
10.1101/2022.10.18.512489 — neuroscience — Posted on 2022-12-14
2264 Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-causing mutations
Hussein, Y.; Tripathi, U.; Choudhary, A.; Nayak, R.; Peles, D.; Rosh, I.; Djamus, J.; Spiegel, R.; Garin-Shkolnik, T.; Stern, S.
10.1101/2022.11.02.514882 — neuroscience — Posted on 2022-12-14
2268 Mega-scale experimental analysis of protein folding stability in biology and protein design
Tsuboyama, K.; Dauparas, J.; Chen, J.; Laine, E.; Mohseni Behbahani, Y.; Weinstein, J. J.; Mangan, N. M.; Ovchinnikov, S.; Rocklin, G. J.
10.1101/2022.12.06.519132 — biophysics — Posted on 2022-12-13
2269 A view of the pan-genome of domesticated cowpea (Vigna unguiculata Walp.)
Liang, Q.; Munoz-Amatriain, M.; Shu, S.; Lo, S.; Wu, X.; Carlson, J. W.; Davidson, P.; Goodstein, D. M.; Phillips, J.; Janis, N. M.; Lee, E. J.; Liang, C. N.; Morrell, P. L.; Farmer, A. D.; Xu, P.; Close, T. J.; Lonardi, S.
10.1101/2022.08.22.504811 — genomics — Posted on 2022-12-13
2270 Cellular electrical impedance to profile SARS-CoV-2 fusion inhibitors and to assess the fusogenic potential of spike mutants
Vanhulle, E.; Doijen, J.; Stroobants, J.; Provinciael, B.; Noppen, S.; Schols, D.; Stevaert, A.; Vermeire, K.
10.1101/2022.12.13.520307 — microbiology — Posted on 2022-12-13
2273 Convergent Evolution and B-Cell Recirculation inGerminal Centers in a Human Lymph Node
Pelissier, A.; Stratigopoulou, M.; Donner, N.; Dimitriadis, E.; Bende, R. J.; Guikema, J. E.; Martinez, M. R.; van Noesel, C. J. M.
10.1101/2022.11.09.463832 — evolutionary biology — Posted on 2022-12-13
2274 Species invasions shift microbial phenology in a two-decade freshwater time series
Rohwer, R. R.; Hale, R. J.; Vander Zanden, M. J.; Miller, T. R.; McMahon, K. D.
10.1101/2022.08.04.502871 — ecology — Posted on 2022-12-13
2278 Gut bacteria impact host uric acid burden and its association with atherosclerosis
Kasahara, K.; Kerby, R. L.; Zhang, Q.; Pradhan, M.; Mehrabian, M.; Lusis, A. J.; Bergstrom, G.; Backhed, F.; Rey, F. E.
10.1101/2022.12.12.520169 — microbiology — Posted on 2022-12-13
2279 Impact of growth-promoting alternatives on weight gain and gut microbial diversity and activity in piglets
Palanee, J.; Gagnon, N.; Lauzon, K.; Methot, S.; Blais, M.; Talbot, G.; Guay, F.; Lessard, M.; Yergeau, E.; Poulin-Laprade, D.
10.1101/2022.12.12.520170 — microbiology — Posted on 2022-12-13
2280 Preclinical efficacy, safety, and immunogenicity of PHH-1V, a second-generation COVID-19 vaccine, in non-human primates
Prenafeta, A.; Bech-Sabat, G.; Moros, S.; Barreiro, A.; Fernandez, A.; Canete, M.; Roca, M.; Gonzalez, L.; Garriga, C.; Confais, J.; Toussenot, M.; Contamin, H.; Pradenas, E.; Marfil, S.; Blanco, J.; Cebollada Rica, P.; Sistere-Oro, M.; Meyerhans, A.; Pizzorno, A.; Rosa-Calatrava, M.; Prat Cabanas, T.; March, R.; Ferrer, L.
10.1101/2022.12.13.520255 — immunology — Posted on 2022-12-13
2281 Alpha-1 Antitrypsin Limits Neutrophil Extracellular Trap Disruption of Airway Epithelial Barrier Function
Hudock, K. M.; Collins, M. S.; Imbrogno, M. A.; Brewington, J. J.; Ziady, A.; Zhang, N.; Snowball, J. M.; Xu, Y.; Carey, B.; Horio, Y.; O'Grady, S.; Kopras, E.; Meeker, J.; Morgan, H.; Ostmann, A.; Skala, E.; Siefert, M. E.; Na, C.-L.; Gollomp, K.; Mangalmurti, N.; Trapnell, B.; Clancy, J. P.
10.1101/2022.03.18.484920 — immunology — Posted on 2022-12-13
2284 Unraveling the Developmental Dynamic of Visual Exploration of Social Interactions in Autism
Kojovic, N.; Cekic, S.; Castanon, S. H.; Franchini, M.; Sperdin, H. F.; Sandini, C.; Jan, R. K.; Zoeller, D.; Ben Hadid, L.; Bavelier, D.; Schaer, M.
10.1101/2020.09.14.290106 — neuroscience — Posted on 2022-12-13
2286 Repurposing clemastine to target glioblastoma cell stemness
Sun, M. A.; Yang, R.; Liu, H.; Wang, W.; Song, X.; Hu, B.; Reynolds, N.; Roso, K.; Chen, L. H.; Greer, P. K.; Keir, S. T.; McLendon, R. E.; Cheng, S.-Y.; Bigner, D. D.; Ashley, D. M.; Pirozzi, C. J.; He, Y.
10.1101/2022.11.05.515291 — cancer biology — Posted on 2022-12-13
2287 Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S.; Franz, E.; McAloney, C. A.; Vetter, T. A.; Cam, M.; Gross, A. C.; Taslim, C.; Wang, M.; Cannon, M. V.; Oles, A.; Roberts, R. D.
10.1101/2020.11.03.367342 — cancer biology — Posted on 2022-12-13
2288 CNTNAP4 signaling regulates osteosarcoma disease progression
Qin, Q.; Ramesh, S.; Gomez-Salazar, M.; Zhong, L.; Cherief, M.; Pratapneni, A.; Morris, C. D.; McCarthy, E. F.; Zhang, X.; James, A.
10.1101/2022.08.26.505419 — cancer biology — Posted on 2022-12-13
2291 Structural basis for specific RNA recognition by the alternative splicing factor RBM5
Soni, K.; Jagtap, P.; Martinez-Lumbreras, S.; Bonnal, S.; Geerlof, A.; Stehle, R.; Simon, B.; Valcarcel, J.; Sattler, M.
10.1101/2022.12.12.520159 — biochemistry — Posted on 2022-12-13
2294 Genomic, Functional and Structural Analyses Reveal Mechanisms of Evolutionary Innovation within the Sea Anemone 8 Toxin Family
Ashwood, L. M.; Elnahriry, K. A.; Stewart, Z. K.; Shafee, T.; Naseem, M. U.; Szanto, T. G.; van der Burg, C. A.; Smith, H. L.; Surm, J. M.; Undheim, E. A. B.; Madio, B.; Hamilton, B. R.; Guo, S.; Wai, D. C. C.; Coyne, V. L.; Phillips, M. J.; Dudley, K. J.; Hurwood, D. A.; Panyi, G.; King, G. F.; Pavasovic, A.; Norton, R. S.; Prentis, P. J.
10.1101/2022.12.08.518931 — genetics — Posted on 2022-12-13
2297 A novel mechanistic framework for precise sequence replacement using reverse transcriptase and diverse CRISPR-Cas systems
Kim, Y. B.; Pierce, E. B.; Brown, M.; Peterson, B. A.; Sanford, D.; Fear, J.; Nicholl, D.; San Pedro, E.; Reynolds, G. M.; Hunt, J. E.; Schwark, D. G.; Jali, S.; Graham, N.; Cesarz, Z.; Chapman, T. A. L.; Watts, J. M.; Hummel, A. W.
10.1101/2022.12.13.520319 — molecular biology — Posted on 2022-12-13
2299 A study of the expression of germline-specific paralogs of the ubiquitously expressed NAC complex revealed their association with centrosomes
Mikhaleva, E. A.; Akulenko, N. V.; Olenkina, O. M.; Abramov, Y. A.; Lavrov, S. A.; Leinsoo, T. A.; Kogan, G. L.; Gvozdev, V. A.
10.1101/2022.12.12.520084 — molecular biology — Posted on 2022-12-13
2300 OPENPichia: building a free-to-operate Komagataella phaffii protein expression toolkit
Van Herpe, D.; Vanluchene, R.; Vandewalle, K.; Vanmarcke, S.; Wyseure, E.; Van Moer, B.; Eeckhaut, H.; Fijalkowska, D.; Grootaert, H.; Lonigro, C.; Meuris, L.; Michielsen, G.; Naessens, J.; Roels, C.; van Schie, L.; De Rycke, R.; De Bruyne, M.; Borghgraef, P.; Claes, K.; Callewaert, N.
10.1101/2022.12.13.519130 — molecular biology — Posted on 2022-12-13
2302 Atmospheric hydrogen oxidation extends to the domain archaea
Leung, P. M.; Grinter, R.; Tudor-Matthew, E.; Jimenez, L.; Lee, H.; Milton, M.; Hanchapola, I.; Tanuwidjaya, E.; Peach, H.; Carere, C.; Stott, M.; Schittenhelm, R. B.; Greening, C.
10.1101/2022.12.13.520232 — microbiology — Posted on 2022-12-13
2304 African army ants at the forefront of virome surveillance in a remote tropical forest
Fritz, M.; Reggiardo, B.; Filloux, D.; Claude, L.; Fernandez, E.; Mahe, F.; Kraberger, S.; Custer, J. M.; Becquart, P.; Ndong Mebaley, T.; Bohou Kombila, L.; Lenguiya, L. H.; Boundenga, L.; Mombo, I. M.; Maganga, G. D.; Niama, F. R.; Koumba, J.-S.; Ogliastro, M.; Yvon, M.; Martin, D.; Blanc, S.; Varsani, A.; Leroy, E.; Roumagnac, P.
10.1101/2022.12.13.520061 — microbiology — Posted on 2022-12-13
2307 Genetic Substrates of Brain Vulnerability and Resilience in APOE2 Mice Transitioning from Midlife to Old Age
Mahzarnia, A.; Moon, H. S.; Stout, J. A.; Anderson, R. J.; Strain, M.; Tremblay, J. T.; Han, Z. Y.; Niculescu, A. R.; MacFarlane, A.; King, J.; Ashley-Koch, A.; Clark, D. P.; Lutz, M. W.; Badea, A.
10.1101/2022.12.12.520146 — neuroscience — Posted on 2022-12-13
2309 Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables
Brummer, A. B.; Xella, A.; Woodall, R.; Adhikarla, V.; Cho, H.; Gutova, M. B.; Brown, C. E.; Rockne, R. C.
10.1101/2022.09.22.508748 — cancer biology — Posted on 2022-12-13
2316 Characterization of the mIF4G domains in the RNA surveillance protein Upf2
Colon, E. M.; Haddock, L. A.; Lasalde, C.; Lin, Q.; Ramirez-Lugo, J. S.; Gonzalez, C. I.
10.1101/2022.12.12.519865 — biochemistry — Posted on 2022-12-13
2317 Dynamics of lipidome in a colon simulator
Krakstrom, M.; Alves, M. A.; Dickens, A. M.; Forssten, S. D.; Ouwehand, A. C.; Hyotylainen, T.; Oresic, M.; Lamichhane, S.
10.1101/2022.12.13.520210 — biochemistry — Posted on 2022-12-13
2322 Antibiotic resistance genes in sewages from hospitals and the urban setting in a Peruvian city in the highlands
Poterico, J. A.; Jaramillo-Valverde, L.; Pablo-Ramirez, N.; Roa-Linares, V.; Martinez-Jaramillo, C.; Alvites-Arrieta, S.; Ubillus, M.; Palma-Lozano, D.; Castrejon-Cabanillas, R.; Davison, S.; Gomez, A.; Guio, H.
10.1101/2022.12.13.520267 — molecular biology — Posted on 2022-12-13
2323 Transcription factor clusters enable target search but do not contribute to target gene activation
Meeussen, J. V. W.; Pomp, W.; Brouwer, I.; de Jonge, W. J.; Patel, H. P.; Lenstra, T. L.
10.1101/2022.12.13.520200 — molecular biology — Posted on 2022-12-13
2324 Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters
Liu, X.; Park, H.-S.; Matsuoka, Y.; Santos, C.; Yang, L.; Luongo, C.; Moore, I.; Johnson, R.; Garza, N.; Zhang, P.; Lusso, P.; Best, S.; Buchholz, U.; Le Nouën, C.
10.1101/2022.12.12.520032 — microbiology — Posted on 2022-12-13
2325 Dual Impacts of a Glycan Shield on the Envelope Glycoprotein B of HSV-1: Evasion from Human Antibodies In Vivo and Neurovirulence
Fukui, A.; Maruzuru, Y.; Ohno, S.; Nobe, M.; Iwata, S.; Takeshima, K.; Koyanagi, N.; Kato, A.; Kitazume, S.; Yamaguchi, Y.; Kawaguchi, Y.
10.1101/2022.12.12.519993 — microbiology — Posted on 2022-12-13
2327 Bacterial colonizers of Nematostella vectensis are initially selected by the host before interactions between bacteria determine further succession
Domin, H.; Zimmermann, J.; Taubenheim, J.; Fuentes Reyes, G.; Saueressig, L.; Prasse, D.; Hoeppner, M.; Schmitz, R. A.; Hentschel, U.; Kaleta, C.; Fraune, S.
10.1101/2022.12.13.520252 — microbiology — Posted on 2022-12-13
2328 Biophysical basis of phage liquid crystalline droplet-mediated antibiotic tolerance in pathogenic bacteria
Boehning, J.; Graham, M.; Letham, S. C.; Davis, L. K.; Schulze, U.; Stansfeld, P. J.; Corey, R. A. J.; Pearce, P.; Tarafder, A. K.; Bharat, T. A. M.
10.1101/2022.12.13.520211 — microbiology — Posted on 2022-12-13
2329 Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron Variants
Wu, J.; Chen, Z.; Gao, Y.; Wang, Z.; Wang, J.; Chiang, B.-Y.; Zhou, Y.; Han, Y.; Zhan, W.; Xie, M.; Jiang, W.; Zhang, X.; Hao, A.; Xia, A.; He, J.; Xue, S.; Mayer, C. T.; Wu, F.; Wang, B.; Zhang, L.; Sun, L.; Wang, Q.
10.1101/2022.12.12.520172 — immunology — Posted on 2022-12-13
2332 Predictive coding during action observation - an Electrocorticographic study
Qin, C.; Michon, F.; Onuki, Y.; Ishishita, Y.; Otani, K.; Kawai, K.; Fries, P.; Gazzola, V.; Keysers, C.
10.1101/2022.12.13.519734 — neuroscience — Posted on 2022-12-13
2333 A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology
Liu, P. W.; Zhang, H.; Werley, C. A.; Pichler, M.; Ryan, S.; Lewarch, C.; Jacques, J.; Grooms, J.; Ferrante, J.; Li, G.; Zhang, D.; Bremmer, N.; Barnett, A.; Chantre, R.; Elder, A. E.; Cohen, A. E.; Williams, L. A.; Dempsey, G. T.; McManus, O. B.
10.1101/2022.12.12.520139 — neuroscience — Posted on 2022-12-13
2334 Diverse beta burst waveform motifs characterize movement-related cortical dynamics
Szul, M. J.; Papadopoulos, S.; Alavizadeh, S.; Daligaut, S.; Schwartz, D.; Mattout, J.; Bonaiuto, J. J.
10.1101/2022.12.13.520225 — neuroscience — Posted on 2022-12-13
2335 Ten years of unpredictable chronic stress in zebrafish: a systematic review and meta-analysis
Gallas-Lopes, M.; Bastos, L. M.; Benvenutti, R.; Panzenhagen, A. C.; Piato, A.; Herrmann, A. P.
10.1101/2022.12.12.520151 — neuroscience — Posted on 2022-12-13
2338 Regulation of neuroinflammation by astrocyte-derived cholesterol.
Wang, H.; Kulas, J. A.; Higginbotham, H.; Kovacs, M. A.; Ferris, H. A.; Hansen, S. B.
10.1101/2022.12.12.520161 — neuroscience — Posted on 2022-12-13
2339 Evaluating hippocampal replay without a ground truth
Takigawa, M.; Huelin Gorriz, M.; Tirole, M.; Bendor, D.
10.1101/2022.12.12.520040 — neuroscience — Posted on 2022-12-13
2341 Characterizing habit learning in the human brain at the individual and group levels: a multi-modal MRI study
Gera, R.; Bar Or, M.; Tavor, I.; Roll, D.; Cockburn, J.; Barak, S.; Tricomi, E.; O'Doherty, J. P.; Schonberg, T.
10.1101/2022.12.12.520188 — neuroscience — Posted on 2022-12-13
2342 A universal workflow for creation, validation and generalization of detailed neuronal models
Reva, M.; Rössert, C.; Arnaudon, A.; Damart, T.; Mandge, D.; Tuncel, A.; Ramaswamy, S.; Markram, H.; Van Geit, W.
10.1101/2022.12.13.520234 — neuroscience — Posted on 2022-12-13
2345 A tonically active master neuron continuously modulates mutually exclusive motor states at two-time scales
Meng, J.; Ahamed, T.; Yu, B.; Hung, W.; El Mouridi, S.; Zhang, Z.; Wang, Z.; Wen, Q.; Boulin, T.; Gao, S.; Zhen, M.
10.1101/2022.04.06.487231 — neuroscience — Posted on 2022-12-13
2350 Hearables: Feasibility of Recording Cardiac Rhythms from Single Ear Locations
Yarici, M. C.; Von Rosenberg, W.; Hammour, G.; Davies, H.; Amadori, P.; Ling, N.; Demiris, Y.; Mandic, D.
10.1101/2022.12.11.519949 — bioengineering — Posted on 2022-12-13
2358 Internal limiting membrane disruption facilitates engraftment of transplanted human stem cell derived retinal ganglion cells
Aguzzi, E. A.; Zhang, K. Y.; Nagalingam, A.; Quillen, S.; Hariharakumar, S.; Chetla, N.; Madhoun, S.; Edwards, M. M.; Quigley, H.; Zack, D. J.; Johnson, T. V.
10.1101/2022.12.13.519327 — neuroscience — Posted on 2022-12-13
2359 Speaker-induced suppression in EEG during a naturalistic reading and listening task
Kurteff, G. L.; Lester-Smith, R. A.; Martinez, A.; Currens, N.; Holder, J.; Villarreal, C.; Mercado, V. R.; Truong, C.; Huber, C.; Pokharel, P.; Hamilton, L. S.
10.1101/2022.12.13.519519 — neuroscience — Posted on 2022-12-13
2360 Multimodal Imaging-Based Classification of PTSD Using Data-Driven Computational Approaches: A Multisite Big Data Study from the ENIGMA-PGC PTSD Consortium
Zhu, X.; Kim, Y.; Ravid, O.; He, X.; Suarez-Jimenez, B.; Zilcha-Mano, S.; Lazarov, A.; Lee, S.; Abdallah, C. G.; Angstadt, M.; Averill, C. L.; Baird, C. L.; Baugh, L. A.; Blackford, J. U.; Bomyea, J.; Bruce, S. E.; Bryant, R. A.; Cao, Z.; Choi, K.; Cisler, J.; Cotton, A. S.; Daniels, J. K.; Davenport, N. D.; Davidson, R. J.; DeBellis, M. D.; Dennis, E. L.; Densmore, M.; deRoon-Cassini, T.; Disner, S. G.; El Hage, W.; Etkin, A.; Fani, N.; Fercho, K. A.; Fitzgerald, J.; Forster, G. L.; Frijling, J. L.; Geuze, E.; Gonenc, A.; Gordon, E. M.; Gruber, S.; Grupe, D. W.; Guenette, J. P.; Haswell, C. C
10.1101/2022.12.12.519838 — neuroscience — Posted on 2022-12-13
2361 Transgenic mice overexpressing mutant TDP-43 show aberrant splicing of autism associated gene Zmynd11 prior to onset of motor symptoms
Narayanan, R.; Panwar, A.; Butler, T. J.; Cutrupi, A. N.; Kennerson, M.; Vucic, S.; Balasubramaniem, A.; Mangelsdorf, M.; Wallace, R. H.
10.1101/2022.12.11.519991 — neuroscience — Posted on 2022-12-13
2362 Neural computations in prosopagnosia
Faghel-Soubeyrand, S.; Richoz, A.-R.; Waeber, D.; Woodhams, J.; Caldara, R.; Gosselin, F.; Charest, I.
10.1101/2022.12.13.519604 — neuroscience — Posted on 2022-12-13
2364 Awake Hippocampal-Cortical Co-reactivation Is Associated with Forgetting
Tanriverdi, B.; Cowan, E. T.; Metoki, A.; Jobson, K. R.; Murty, V. P.; Chein, J.; Olson, I. R.
10.1101/2022.12.10.519896 — neuroscience — Posted on 2022-12-13
2365 A novel histological staging of hippocampal sclerosis that is evident in grey matter loss in vivo.
Ortega-Cruz, D.; Uceda-Heras, A.; Iglesias, J. E.; Zea-Sevilla, M. A.; Strange, B.; Rabano, A.
10.1101/2022.12.13.520094 — neuroscience — Posted on 2022-12-13
2368 Apolipoprotein E intersects with amyloid-β within neurons
Konings, S. C.; Nyberg, E.; Martinsson, I.; Torres-Garcia, L.; Guimas Almeida, C.; Gouras, G. K.
10.1101/2022.12.13.520238 — neuroscience — Posted on 2022-12-13
2369 Proteomic discovery of chemical probes that perturb protein complexes in human cells
Lazear, M.; Remsberg, J.; Jaeger, M.; Rothamel, K.; Her, H.-l.; DeMeester, K.; Njomen, E.; Hogg, S.; Rahman, J.; Whitby, L.; Won, S. J.; Schafroth, M.; Ogasawara, D.; Yokoyama, M.; Lindsey, G.; Li, H.; Germain, J.; Barbas, S.; Vaughan, J.; Hanigan, T.; Vartabedian, V.; Reinhardt, C.; Dix, M.; Koo, S. J.; Heo, I.; Teijaro, J.; Simon, G.; Ghosh, B.; Abdel-Wahab, O.; Ahn, K.; Saghatelian, A.; Melillo, B.; Schreiber, S.; Yeo, G.; Cravatt, B.
10.1101/2022.12.12.520090 — biochemistry — Posted on 2022-12-13
2372 Read2Tree: scalable and accurate phylogenetic trees from raw reads
Dylus, D.; Altenhoff, A. M.; Majidian, S.; Sedlazeck, F. J.; Dessimoz, C.
10.1101/2022.04.18.488678 — bioinformatics — Posted on 2022-12-13
2373 Light and electron microscopy continuum-resolution imaging of 3D cell cultures
Dimprima, E.; Garcia Montero, M.; Gawrzak, S.; Ronchi, P.; Zagoriy, I.; Schwab, Y.; Jechlinger, M.; Mahamid, J.
10.1101/2021.07.02.450855 — cell biology — Posted on 2022-12-13
2374 NIT: an open-source tool for information theoretic analysis of neural population data
Maffulli, R.; Casal, M.; Celotto, M.; Zucca, S.; Safaai, H.; Fellin, T.; Panzeri, S.
10.1101/2022.12.11.519966 — neuroscience — Posted on 2022-12-13
2375 Does it pay to pay? A comparison of the benefits of open-access publishing across various sub-fields in Biology
Clark, A. D.; Myers, T. C.; Steury, T. D.; Krzton, A.; Yanes, J. A.; Barber, A.; Barry, J. L.; Barua, S.; Eaton, K. M.; Gosavi, D.; Nance, R. L.; Pervaiz, Z. H.; Ugochukwu, C. G.; Hartman, P.; Stevison, L. S.
10.1101/2022.12.10.519925 — scientific communication and education — Posted on 2022-12-13
2378 Wolbachia genomics reveals a potential for a nutrition-based symbiosis in blood-sucking Triatomine bugs
Filee, J.; Agesilas-Lequeux, K.; Lacquehay, L.; Berenger, J. M.; Dupont, L.; Mendonca, V.; Aristeu da Rosa, J.; Harry, M.
10.1101/2022.09.06.506778 — evolutionary biology — Posted on 2022-12-13
2379 Integrating opportunistic and structured non-invasive surveys with spatial capture-recapture models to map connectivity of the Pyrenean brown bear population
Kervellec, M.; Milleret, C.; Vanpe, C.; Quenette, P.-Y.; Sentilles, J.; Palazon, S.; Jordana, I. A.; Jato, R.; Elosegui Irurtia, M. M.; Gimenez, O.
10.1101/2022.05.13.491807 — ecology — Posted on 2022-12-13
2380 marmite defines a novel conserved neuropeptide family mediating nutritional homeostasis
Francisco, A. P.; Tastekin, I.; Fernandes, A. B.; Ezra-Nevo, G.; Deplancke, B.; Oliveira-Maia, A. J.; Gontijo, A. M.; Ribeiro, C.
10.1101/2022.12.12.520095 — neuroscience — Posted on 2022-12-13
2383 Circadian protein regulation in the green lineage I. A phospho-dawn anticipates light onset before proteins peak in daytime.
Noordally, Z. B.; Hindle, M. M.; Martin, S. F.; Seaton, D. D.; Simpson, I.; Le Bihan, T.; Millar, A. J.
10.1101/287862 — plant biology — Posted on 2022-12-13
2384 Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos
McCoy, R. C.; Summers, M. C.; McCollin, A.; Ottolini, C. S.; Ahuja, K.; Handyside, A. H.
10.1101/2022.07.03.498614 — genetics — Posted on 2022-12-13
2386 Simultaneous 3D Cellular Positioning and Apical Dendritic Morphology of Transgenic Fluorescent Mouse CA3 Hippocampal Pyramidal Neurons
Handwerk, C. J.; Bland, K. M.; Denzler, C. J.; Kalinowski, A. R.; Brett, C. A.; Swinehart, B. D.; Rodriguez, H. V.; Cook, H. N.; Vinson, E. C.; Florenz, M. E.; Vidal, G. S.
10.1101/2022.08.12.503761 — neuroscience — Posted on 2022-12-13
2387 Acculturative orientations among Hispanic/Latinx caregivers in the ABCD Study: Associations with caregiver and youth mental health and youth brain function
Meca, A.; Peraza, J. A.; Riedel, M. C.; Hale, W.; Pettit, J. W.; Musser, E. D.; Salo, T.; Flannery, J. S.; Bottenhorn, K. L.; Dick, A. S.; Pintos Lobo, R.; Ucros, L. M.; Greaves, C. A.; Hawes, S. W.; Sanchez, M.; Gonzalez, M. R.; Sutherland, M. T.; Gonzalez, R.; Laird, A. R.
10.1101/2022.07.24.501248 — neuroscience — Posted on 2022-12-13
2388 High Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of HOX/MEIS Gene Expression in Acute Myeloid Leukemia
Barbosa, K.; Deshpande, A.; Perales, M. E.; Xiang, P.; Murad, R.; Minkina, A.; Robertson, N. A.; Schischlik, F.; Lei, X.; Sun, Y.; Brown, A.; Doench, J. G.; Humphries, K.; Ruppin, E.; Shendure, J.; Mali, P.; Adams, P. D.; Deshpande, A. J.
10.1101/2022.12.12.519332 — cancer biology — Posted on 2022-12-13
2389 Site-directed placement of three-dimensional DNA origami
Martynenko, I. V.; Erber, E.; Ruider, V.; Dass, M.; Posnjak, G.; Yin, X.; Altpeter, P.; Liedl, T.
10.1101/2022.12.11.519977 — biophysics — Posted on 2022-12-13
2390 L-SCRaMbLE creates large-scale genome rearrangements in synthetic Sc2.0 chromosomes
Lindeboom, T. A.; Sanchez Olmos, M. d. C.; Schulz, K.; Brinkmann, C. K.; Ramirez Rojas, A. A.; Hochrein, L.; Schindler, D.
10.1101/2022.12.12.519280 — synthetic biology — Posted on 2022-12-13
2391 A common venomous ancestor? Prevalent bee venom genes evolved before the aculeate stinger while few major toxins are bee-specific
Koludarov, I.; Velasque, M.; Timm, T.; Greve, C.; Hamadou, A. B.; Gupta, D. K.; Lochnit, G.; Heinzinger, M.; Vilcinskas, A.; Gloag, R.; Harpur, B. A.; Podsiadlowski, L.; Rost, B.; Jackson, T.; Dutertre, S.; Stolle, E.; von Reumont, B. M.
10.1101/2022.01.21.477203 — evolutionary biology — Posted on 2022-12-13
2393 The fast diffusion of NKCC1 along the axon is driven by glutamatergic activity
Come, E.; Pol, E.; Merlaud, Z.; Gouhier, J.; Russeau, M.; MARQUES, X.; Scotto-Lomassese, S.; Moutkine, I.; LEVI, S.
10.1101/2022.12.11.519960 — neuroscience — Posted on 2022-12-13
2395 The Arabidopsis Target of Rapamycin (TOR) kinase regulates ammonium assimilation and glutamine metabolism
Ingargiola, C.; Jehanno, I.; Forzani, C.; Marmagne, A.; Broutin, J.; Clement, G.; Leprince, A.-S.; Meyer, C.
10.1101/2022.12.09.519783 — plant biology — Posted on 2022-12-13
2396 A comprehensive model of Drosophila epithelium reveals the role of embryo geometry and cell topology in mechanical responses
Cheikh, M. I.; Tchoufag, J.; Osterfield, M.; Dean, K.; Bhaduri, S.; Zhang, C.; Mandadapu, K. K.; Doubrovinski, K.
10.1101/2022.08.12.503803 — biophysics — Posted on 2022-12-13
2397 IIIandMe: An Algorithm for Chromosome-scale Haplotype Determination Using Genome-wide Variants of Three Haploid Reproductive Cells
Qu, H.; Li, R.; Yu, L.; Chen, W.; Feng, Y.; Jia, Q.; Traband, R.; Wang, X.; Wang, S.; He, L.; Wang, Z.; Qu, M.; Ferrante, S. P.; Zhu, J.; Zhong, W.; Roose, M.; Jia, Z.
10.1101/2022.12.07.519546 — bioinformatics — Posted on 2022-12-13
2398 Antisense oligonucleotide-mediated perturbation of long non-coding RNA reveals functional features in stem cells and across cell types
Yip, C. W.; Hon, C.-C.; Yasuzawa, K.; Mundackal Sivaraman, D.; Ramilowski, J. A.; Shibayama, Y.; Agrawal, S.; Prabhu, A. V.; Parr, C.; Severin, J.; Lan, Y. J.; Dostie, J.; Nishiyori-Sueki, H.; Tagami, M.; Ito, M.; Lopez-Redondo, F.; Kouno, T.; Chang, J.-C.; Luginbuhl, J.; Kato, M.; Murata, M.; Yip, W. H.; Shu, X.; Abugessaisa, I.; Hasegawa, A.; Suzuki, H.; Yagi, K.; Kasukawa, T.; de Hoon, M. J. L.; Carninci, P.; Shin, J. W.
10.1101/2022.02.16.480297 — genomics — Posted on 2022-12-13
2403 A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence
Hachani, A.; Giulieri, S. G.; Guerillot, R.; Walsh, C. J.; Herisse, M.; Soe, Y. M.; Baines, S. L.; Thomas, D. R.; Cheung, S. D.; Hayes, A. S.; Cho, H.-J.; Newton, H. J.; Pidot, S.; Massey, R. C.; Howden, B. P.; Stinear, T. P.
10.1101/2022.12.11.519971 — microbiology — Posted on 2022-12-13
2407 marmite defines a novel conserved neuropeptide family mediating nutritional homeostasis
Francisco, A. P.; Tastekin, I.; Fernandes, A. B.; Ezra-Nevo, G.; Deplancke, B.; Oliveira-Maia, A. J.; Gontijo, A. M.; Ribeiro, C.
10.1101/2022.12.12.520095 — neuroscience — Posted on 2022-12-13
2408 Surface SV2A-Syt1 nanoclusters act as a sequestration hub that limits dynamin-1 recruitment and targeting to recycling synaptic vesicles
Small, C.; Harper, C.; Jiang, A.; Kontaxi, C.; Yak, N.; Malapaka, A.; Davenport, E.; Wallis, T.; Gormal, R.; Joensuu, M.; Martinez-Marmol, R.; Cousin, M. A.; Meunier, F. A.
10.1101/2022.12.12.520075 — neuroscience — Posted on 2022-12-13
2410 Unlocking the microblogging potential for science and medicine
Sarkar, A.; Giros, A.; Mockly, L.; Moore, J.; Moore, A.; Nagareddy, A.; Fu, B.; Fiscutean, A.; Chhugani, K.; Darci-Maher, N.; Patel, Y.; Sarwal, V.; Chang, Y.; Ginjala, S.; Garmire, L. X.; Bao, R.; Sankararaman, S.; Chikhi, R.; Mangul, S.
10.1101/2022.04.22.488804 — scientific communication and education — Posted on 2022-12-13
2411 Improving cassava bacterial blight resistance by editing the epigenome
Veley, K. M.; Elliott, K.; Jensen, G.; Zhong, Z.; Feng, S.; Yoder, M.; Gilbert, K. B.; Berry, J. C.; Lin, Z.-J. D.; Ghoshal, B.; Gallego-Bartolome, J.; Norton, J.; Motomura-Wages, S.; Carrington, J. C.; Jacobsen, S. E.; Bart, R.
10.1101/2022.01.04.474801 — plant biology — Posted on 2022-12-13
2414 Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer.
Khan, I.; Gril, B.; Paranjape, A.; Robinson, C.; Difilippantonio, S.; Biernat, W.; Bienkowski, M.; Peksa, R.; Duchnowska, R.; Jassem, J.; Brastianos, P. K.; Metellus, P.; Bialecki, E.; Woodroofe, C. C.; Wu, H.; Swenson, R.; Steeg, P. S.
10.1101/2022.08.09.503253 — cancer biology — Posted on 2022-12-13
2418 Prosocial behavior, social reward and empathy in adult male and female mice
Misiolek, K.; Klimczak, M.; Chroszcz, M.; Szumiec, L.; Bryksa, A.; Przyborowicz, K.; Rodriguez Parkitna, J.; Harda, Z.
10.1101/2022.08.19.504492 — animal behavior and cognition — Posted on 2022-12-13
2419 An amino acid transporter AAT1 plays a pivotal role in chloroquine resistance evolution in malaria parasites
Amambua-Ngwa, A.; Button-Simons, K. A.; Li, X.; Kumar, S.; Brenneman, K. V.; Ferrari, M.; Checkley, L. A.; Haile, M. T.; Shoue, D. A.; McDew-White, M.; Tindall, S. M.; Reyes, A.; Delgado, E.; Dahlhoff, H.; Larbalestier, J. K.; Amato, R.; Pearson, R. D.; Taylor, A. B.; Nosten, F. H.; D'Alessandro, U.; Kwiatkowski, D.; Cheeseman, I. H.; Kappe, S. H. I.; Avery, S. V.; Conway, D. J.; Vaughan, A. M. V.; Ferdig, M. T.; Anderson, T. J. C.
10.1101/2022.05.26.493611 — genomics — Posted on 2022-12-13
2420 Highly accurate long reads are crucial for realizing the potential of biodiversity genomics
Hotaling, S.; Wilcox, E. R.; Heckenhauer, J.; Stewart, R. J.; Frandsen, P. B.
10.1101/2022.07.10.499467 — genomics — Posted on 2022-12-13
2425 Genomics of Preaxostyla Flagellates Illuminates Evolutionary Transitions and the Path Towards Mitochondrial Loss
Novak, L. V. F.; Treitli, S. C.; Pyrih, J.; Hałakuc, P.; Pipaliya, S. V.; Vacek, V.; Brzon, O.; Soukal, P.; Eme, L.; Dacks, J. B.; Karnkowska, A.; Elias, M.; Hampl, V.
10.1101/2022.11.24.517819 — microbiology — Posted on 2022-12-13
2426 Novel synergies and isolate specificities in the drug interactions landscape of Mycobacterium abscessus
Van, N.; Degefu, Y. N.; Leus, P. A.; Larkins-Ford, J.; Klickstein, J.; Maurer, F. P.; Stone, D.; Poonawala, H.; Thorpe, C. M.; Smith, T. C.; Aldridge, B. B.
10.1101/2022.12.12.520102 — microbiology — Posted on 2022-12-13
2430 A Principal Odor Map Unifies Diverse Tasks in Human Olfactory Perception
Lee, B. K.; Mayhew, E. J.; Sanchez-Lengeling, B.; Wei, J. N.; Qian, W. W.; Little, K.; Andres, M.; Nguyen, B. B.; Moloy, T.; Parker, J. K.; Gerkin, R. C.; Mainland, J. D.; Wiltschko, A. B.
10.1101/2022.09.01.504602 — neuroscience — Posted on 2022-12-13
2431 Statistical omics data integration identifies potential therapeutic targets for synucleinopathies
El Bouhaddani, S.; Höllerhage, M.; Uh, H.-W.; Bickle, M.; Moebius, C.; Höglinger, G.; Houwing-Duistermaat, J.
10.1101/2022.08.10.503452 — neuroscience — Posted on 2022-12-13
2432 Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons
Qian, J.; Guan, X.; Xie, B.; Xu, C.; Niu, J.; Tang, X.; Li, C.; Colecraft, H.; Jaenisch, R.; Liu, X. S.
10.1101/2022.11.30.518560 — physiology — Posted on 2022-12-13
2433 Identification of Barley Enhancers across Genome via STARR-seq
Wanlin, Z.; Shi, H.; Wang, Z.; Huang, Y.; Ni, L.; Chen, X.; Liu, Y.; Li, H.; Li, C.; Liu, Y.
10.1101/2022.12.10.519735 — genomics — Posted on 2022-12-13
2434 Sequencing-free Tissue-wide Spatial Profiling of Post-transcriptional Regulations
Ji, X.; Fang, P.; Zhao, X.; Xiong, C.; Yang, Q.; Wan, Y.; Yan Do, R.; Wang, Z.; Qi, L.; Huang, L.; Zhang, W.; Wang, X.; Shi, P.
10.1101/2022.12.11.519542 — genomics — Posted on 2022-12-13
2435 Phenotypic and transcriptomic analyses reveal major differences between apple and pear scab nonhost resistance
VERGNE, E.; CHEVREAU, E.; RAVON, E.; GAILLARD, S.; PELLETIER, S.; BAHUT, M.; PERCHEPIED, L.
10.1101/2021.06.01.446506 — genomics — Posted on 2022-12-13
2440 Non-Local Conceptual Combination
Parrish, A.; Rodriguez, A.; Pylkkanen, L.
10.1101/2022.12.11.519989 — neuroscience — Posted on 2022-12-13
2442 Astrocyte glucocorticoid signaling mediates cognitive impairment induced by early-life stress
Adedipe, I. I.; Depaauw-Holt, L. R.; Latraverse-Arquilla, J.; Vaugeois, J.; Duquenne, M.; Rogers, B.; Peyrard, S.; Bosson, A.; Murphy-Royal, C.
10.1101/2022.12.11.519598 — neuroscience — Posted on 2022-12-13
2443 In-silico and in-vitro morphometric analysis of intestinal organoids
Montes-Olivas, S. L.; Legge, D.; Lund, A.; Fletcher, A. G.; Williams, A. C.; Marucci, L.; Homer, M.
10.1101/2022.12.08.519603 — systems biology — Posted on 2022-12-13
2448 Conservation of antiviral systems across domains of life reveals novel immune mechanisms in humans
Cury, J.; Mordret, E.; Hernandez-Trejo, V.; Tesson, F.; Ofir, G.; Poirier, E. Z.; Bernheim, A.
10.1101/2022.12.12.520048 — genomics — Posted on 2022-12-12
2451 Salmonella infection induces the reorganisation of follicular dendritic cell networks concomitant with the failure to generate germinal centres
Marcial-Juarez, E.; Perez-Toledo, M.; Nayar, S.; Pipi, E.; Alshayea, A.; Persaud, R.; Jossi, S. E.; Lamerton, R.; Barone, F.; Henderson, I. R.; Cunningham, A. F.
10.1101/2022.12.11.519997 — immunology — Posted on 2022-12-12
2453 Coexisting morpho-biotypes unveil the regulatory bases of phenotypic plasticity in pancreatic ductal adenocarcinoma
Di Chiaro, P.; Nacci, L.; Brandini, S.; Polletti, S.; Donati, B.; Gualdrini, F.; Frige', G.; Mazzarella, L.; Ciarrocchi, A.; Zerbi, A.; Spaggiari, P.; Barozzi, I.; Diaferia, G. R.; Natoli, G.
10.1101/2022.12.12.520054 — cancer biology — Posted on 2022-12-12
2458 Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere
Dendooven, T.; Zhang, Z.; Yang, J.; McLaughlin, S. H.; Schwab, J.; Scheres, S. H. W.; Yatskevich, S.; Barford, D.
10.1101/2022.12.12.520091 — biochemistry — Posted on 2022-12-12
2459 Ancestry dynamics and trait selection in a designer cat breed
Kaelin, C. B.; McGowan, K. A.; Hutcherson, A. D.; DeLay, J. M.; Barsh, G. S.
10.1101/2022.12.12.520105 — genetics — Posted on 2022-12-12
2460 Isolation of highly purified genomic material from mitochondria of muscle tissue cells
Tatarkina, M. A.; Lobanova, V. V.; Kozenkov, I. I.; Efimenko, B. E.; Dzhigkaev, A. K.; Popadin, K. Y.; Gunbin, K. V.; Goncharov, A. G.
10.1101/2022.12.12.520064 — molecular biology — Posted on 2022-12-12
2461 FK506-binding protein 2 participates in proinsulin folding
Hoefner, C.; Bryde, T. H.; Pihl, C.; Tiedemann, S. N.; Bresson, S. E.; Hotiana, H. A.; Khilji, M. S.; dos Santos, T.; Puglia, M.; Pisano, P.; Majewska, M.; Durzynska, J.; Klindt, K.; Klusek, J.; Perone, M. J.; Bucki, R.; Hagglund, P. M.; Gourdon, P.; Gotfryd, K.; Urbaniak, E.; Borowiak, M.; Wierer, M.; Macdonald, P. E.; Mandrup-Poulsen, T.; Marzec, M. T.
10.1101/2022.12.12.520056 — molecular biology — Posted on 2022-12-12
2462 Adaptation of a transmitted/founder simian-human immunodeficiency virus for enhanced replication in rhesus macaques
Bauer, A.; Lindemuth, E.; Joy, J.; Marino, F. E.; Docken, S. S.; Krause, R.; Mallick, S.; McCormick, K.; Holt, C.; Georgiev, I.; Felber, B. K.; Keele, B. F.; Veazey, R.; Davenport, M. P.; Li, H.; Shaw, G.; Bar, K. J.
10.1101/2022.12.12.520031 — microbiology — Posted on 2022-12-12
2463 Evolution of lineage-specific trafficking proteins and a novel post-Golgi trafficking pathway in Apicomplexa
Klinger, C. M.; Jimenez Ruiz, E.; Mourier, T.; Klingl, A.; Lemgruber, L.; Pain, A.; Dacks, J. B.; Meissner, M.
10.1101/2022.12.12.520010 — microbiology — Posted on 2022-12-12
2464 Horizontal transmission of penicillin binding protein 1A caused a nationwide spread of β-lactam resistance in pneumococci
Nakano, S.; Fujisawa, T.; Chang, B.; Ito, Y.; Kitamura, N.; Suga, S.; Matsumura, Y.; Yamamoto, M.; Nagao, M.; Ohnishi, M.; Sugai, M.
10.1101/2022.12.11.519994 — microbiology — Posted on 2022-12-12
2466 Novel synergies and isolate specificities in the drug interactions landscape of Mycobacterium abscessus
Van, N.; Degefu, Y. N.; Leus, P. A.; Larkins-Ford, J.; Klickstein, J.; Maurer, F. P.; Stone, D.; Poonawala, H.; Thorpe, C. M.; Smith, T. C.; Aldridge, B. B.
10.1101/2022.12.12.520102 — microbiology — Posted on 2022-12-12
2467 A genome-wide screen in macrophages identifies PTEN as required for myeloid restriction of Listeria monocytogenes infection
Glover, R. C.; Schwardt, N. H.; Leano, S.-K. E.; Sanchez, M. E.; Thomason, M. K.; Olive, A. J.; Reniere, M. L.
10.1101/2022.12.12.520030 — microbiology — Posted on 2022-12-12
2468 Multimodal Mapping of Human Lymphopoiesis Reveals B and T/NK/ILC Lineages are Subjected to Cell-Intrinsic versus Flt3L-Dependent Regulation
Alhaj Hussen, K.; Chabaane, E.; Nelson, E.; Lekiashvili, S.; Diop, S.; Keita, S.; Evrard, b.; Lardenois, A.; Delord, M.; Verhoeyen, E.; Cornils, K.; Kasraian, Z.; Macintyre, E.; Cumano, A.; garrick, D.; Goodhardt, M.; Andrieu, G. P.; Asnafi, V.; Chalmel, F.; Canque, B.
10.1101/2022.12.12.520022 — immunology — Posted on 2022-12-12
2470 Seasonal dynamics of a complex cheilostome bryozoan symbiosis - vertical transfer challenged
Bogdanov, E. A.; Vishnyakov, A. E.; Kotenko, O. N.; Grischenko, A. V.; Letarov, A. V.; Ostrovsky, A. N.
10.1101/2022.12.09.519770 — zoology — Posted on 2022-12-12
2473 Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheep
Jacobson, G.; Kraakman, K.; Wallace, O.; Pan, J.; Williamson, A.; Hennebry, A.; Smolenski, G.; Cursons, R.; Hodgkinson, S.; Kelton, W.
10.1101/2022.12.11.519990 — bioengineering — Posted on 2022-12-12
2474 Whole-genome sequencing across 449 samples spanning 47 ethnolinguistic groups provides insights into genetic diversity in Nigeria
Joshi, E.; Biddanda, A.; Popoola, J.; Yakubu, A.; Osakwe, O.; Attipoe, D.; 54gene Team, ; NCD-GHS Consortium, ; Dogbo, E.; Salako, B.; Nash, O.; Salako, O.; Oyedele, O.; Eze-Echesi, G.; Fatumo, S.; Ene-Obong, A.; O'Dushlaine, C.
10.1101/2022.12.09.519178 — genomics — Posted on 2022-12-12
2479 Using machine learning to detect coronaviruses potentially infectious to humans
Gonzalez-Isunza, G.; Jawaid, M.- Z.; Liu, P.; Cox, D. L.; Vazquez, M.; Arsuaga, J.
10.1101/2022.12.11.520008 — microbiology — Posted on 2022-12-12
2480 Cuticle development and underlying transcriptome-metabolome associations during early seedling establishment
Chen, K.; Bhunia, R.; McNinch, C.; Campidilli, G.; Hassan, A.; Li, L.; Nikolau, B. J.; Yandeau-Nelson, M. D.
10.1101/2022.12.09.519822 — systems biology — Posted on 2022-12-12
2481 A mechanistic model towards ecological inclusion for a better plant growth understanding
Nasti, L.; Del Dottore, E.; Tedone, F.; Palladino, M.; Mazzolai, B.; Marcati, P.
10.1101/2022.12.09.519755 — plant biology — Posted on 2022-12-12
2482 Single cell guided deconvolution of bulk transcriptomics recapitulates differentiation stages of acute myeloid leukemia and predicts drug response
Karakaslar, E. O.; Severens, J. F.; Sanchez-Lopez, E.; van Veelen, P. A.; Zlei, M.; van Dongen, J. J.; Otte, A. M.; Halkes, C. J.; van Balen, P.; Veelken, H.; Reinders, M. J.; Griffioen, M.; van den Akker, E. B.
10.1101/2022.12.09.519738 — cancer biology — Posted on 2022-12-12
2483 Phantasus: web-application for visual and interactive gene expression analysis
Kleverov, M.; Zenkova, D.; Kamenev, V.; Sablina, M.; Artyomov, M.; Sergushichev, A.
10.1101/2022.12.10.519861 — bioinformatics — Posted on 2022-12-12
2484 3D multiplexed tissue imaging reconstruction and optimized region-of-interest (ROI) selection through deep learning model of channels embedding
Burlingame, E.; Ternes, L.; Lin, J.-R.; Chen, Y.-A.; Kim, E. N.; Gray, J. W.; Santagata, S.; Sorger, P. K.; Chang, Y. H.
10.1101/2022.12.09.519807 — bioinformatics — Posted on 2022-12-12
2486 TargetCall: Eliminating the Wasted Computation in Basecalling via Pre-Basecalling Filtering
Cavlak, M. B.; Singh, G.; Alser, M.; Firtina, C.; Lindegger, J.; Sadrosadati, M.; Mansouri Ghiasi, N.; Alkan, C.; Mutlu, O.
10.1101/2022.12.09.519749 — bioinformatics — Posted on 2022-12-12
2489 Biological Cartography: Building and Benchmarking Representations of Life
Celik, S.; Huetter, J.-C.; Melo-Carlos, S.; Lazar, N.; Mohan, R.; Tillinghast, C.; Biancalani, T.; Fay, M.; Earnshaw, B.; Haque, I.
10.1101/2022.12.09.519400 — bioinformatics — Posted on 2022-12-12
2490 De novo designed ice-binding proteins from twist-constrained helices
de Haas, R. J.; Tas, R. P.; van den Broek, D.; Nguyen, H.; Kang, A.; Bera, A.; King, N. P.; Voets, I.; Vries, R. d.
10.1101/2022.12.09.519714 — bioengineering — Posted on 2022-12-12
2497 HLApollo: A superior transformer model for pan-allelic peptide-MHC-I presentation prediction, with diverse negative coverage, deconvolution and protein language features.
Thrift, W. J.; Lounsbury, N. W.; Broadwell, Q.; Heidersbach, A.; Freund, E.; Phung, Q.; Abdolazimi, Y.; Chen, J.; Capietto, A.-H.; Tong, A.-J.; Rose, C. M.; Blanchette, C.; Lill, J.; Haley, B.; Delamarre, L.; Bourgon, R.; Liu, K.; Jhunjhunwala, S.
10.1101/2022.12.08.519673 — immunology — Posted on 2022-12-12
2498 It takes neurons to understand neurons: Digital twins of visual cortex synthesize neural metamers
Cobos, E.; Muhammad, T.; Fahey, P. G.; Ding, Z.; Ding, Z.; Reimer, J.; Sinz, F. H.; Tolias, A.
10.1101/2022.12.09.519708 — neuroscience — Posted on 2022-12-12
2506 Rejuvenating Senescent Cells and Organisms with Only Ultrasound
Kureel, S. K.; Maroto, R.; Powell, S.; Margadant, F.; Blair, B.; Rasmussen, B.; Sheetz, M.
10.1101/2022.12.08.519320 — physiology — Posted on 2022-12-12
2512 RNA-Chrom: a manually-curated analytical database of RNA-chromatin interactome
Ryabykh, G.; Kuznetsov, S.; Korostelev, Y.; Sigorskikh, A.; Zharikova, A.; Mironov, A.
10.1101/2022.12.10.519346 — bioinformatics — Posted on 2022-12-12
2513 Towards a Clinically-based Common Coordinate Framework for the Human Gut Cell Atlas - The Gut Models
Burger, A.; Baldock, R.; Adams, D. J.; Din, S.; Papatheodorou, I.; Glinka, M.; Hill, B.; Houghton, D.; Sharghi, M.; Wicks, M.; Arends, M. J.
10.1101/2022.12.08.519665 — bioinformatics — Posted on 2022-12-12
2518 Snakeobjects: an object-oriented workflow management system
Yamrom, B.; Lee, Y.-h.; Marks, S.; Chorbadjiev, L.; Meyer, H. V.; Iossifov, I.
10.1101/2022.12.08.519599 — bioinformatics — Posted on 2022-12-12
2519 Nanobody CDR3 mimetics enhance SOS1-catalyzed nucleotide exchange on RAS
Van holsbeeck, K.; Fischer, B.; Gonzalez, S.; Gadais, C.; Versees, W.; Martins, J. C.; Martin, C.; Wohlkonig, A.; Steyaert, J.; Ballet, S.
10.1101/2022.12.09.519747 — bioengineering — Posted on 2022-12-12
2520 Low-intensity transcranial focused ultrasound changes pain-associated behaviors by modulating pain processing brain circuits
Kim, M. G.; Yu, K.; Fouda, R.; Argueta, D.; Kiven, S.; Ni, Y.; Niu, X.; Chen, Q.; Kim, K.; Gupta, K.; He, B.
10.1101/2022.12.07.519518 — bioengineering — Posted on 2022-12-12
2521 A survey of proteomic variation across two ethnic groups in Nigeria and its relationship to obesity risk
Biddanda, A.; Perez de Arce, K.; Eze-Echesi, G.; Nwuba, C.; Ibrahim, Y.; Oyedele, O.; Joshi, E.; Alalade, B.; Ajayi, O.; Nwatu, C.; Yakubu, A.; Ene-Obong, A.; Popoola, J.; O'Dushlaine, C.; Fekkes, P.
10.1101/2022.12.09.519773 — genomics — Posted on 2022-12-12
2522 Comparative Analysis of Global Hepatic Gene Expression in Adolescents and Adults with Non-alcoholic Fatty Liver Disease
Gawrieh, S.; Karns, R.; Kleiner, D. E.; Olivier, M.; Jenkins, T.; Inge, T. H.; Chalasani, N. P.; Xanthakos, S.
10.1101/2022.12.08.519606 — genetics — Posted on 2022-12-12
2523 Persistent gene flow suggests an absence of reproductive isolation in an African antelope speciation model
Wang, X.; Pedersen, C.-E. T.; Athanasiadis, G.; Garcia-Erill, G.; Hanghoj, K.; Bertola, L. D.; Rasmussen, M. S.; Schubert, M.; Liu, X.; Li, Z.; Lin, L.; Jorsboe, E.; Nursyifa, C.; Liu, S.; Muwanika, V.; Masembe, C.; Chen, L.; Wang, W.; Moltke, I.; Siegismund, H. R.; Albrechtsen, A.; Heller, R.
10.1101/2022.12.08.519574 — evolutionary biology — Posted on 2022-12-12
2524 Trait-specific indirect effects underlie variation in the response of spiders to cannibalistic social partners
Henriques, J. F.; Lacava, M.; Guzman, C.; Gavin-Centol, M. P.; Lupion, D. R.; Ruiz, A.; Viera, C.; Moya-Larano, J.; Magalhaes, S.
10.1101/2022.12.08.519483 — evolutionary biology — Posted on 2022-12-12
2532 Taxonomically mixed blue mussel Mytilus populations are spatially heterogeneous and temporally unstable in the subarctic Barents Sea
Marchenko, J.; Khaitov, V.; Katolikova, M.; Sabirov, M.; Malavenda, S.; Gantsevich, M.; Basova, L.; Genelt-Yanovsky, E.; Strelkov, P.
10.1101/2022.12.08.519596 — ecology — Posted on 2022-12-12
2535 Urbanisation impacts the diversity, coloration, and body size of wild bees in a Mediterranean city
Badiane, A.; Ropars, L.; Flacher, F.; Schurr, L.; Zakardjian, M.; Affre, L.; Deschamps-Cottin, M.; Gachet, S.; Robles, C.; Geslin, B.
10.1101/2022.12.09.519739 — ecology — Posted on 2022-12-12
2537 A Deep Learning Approach for Histology-Based Nuclei Segmentation and Tumor Microenvironment Characterization
Rong, R.; Sheng, H.; Jin, K. W.; Wu, F.; Luo, D.; Wen, Z.; Tang, C.; Yang, D. M.; Jia, L.; Amgad, M.; Cooper, L. A. D.; Xie, Y.; Zhan, X.; Wang, S.; Xiao, G.
10.1101/2022.12.08.519641 — pathology — Posted on 2022-12-12
2543 Creating an Ignorance-Base: Exploring Known Unknowns in the Scientific Literature
Boguslav, M. R.; Salem, N. M.; White, E. K.; Sullivan, K. J.; Araki, S. P.; Bada, M.; Hernandez, T. L.; Leach, S. M.; Hunter, L. E.
10.1101/2022.12.08.519634 — bioinformatics — Posted on 2022-12-12
2544 Highly dynamic evolution of the chemosensory gene repertoire driven by gene gain and expansion across subterranean beetles
Balart-Garcia, P.; Bradford, T. M.; Beasley-Hall, P. G.; Polak, S.; Ribera, I.; Cooper, S. J.; Fernandez, R.
10.1101/2022.12.08.519422 — evolutionary biology — Posted on 2022-12-12
2549 The Global Environment Facility approach for allocating biodiversity funding to countries
Mcowen, C.; Burgess, N. D.; Ash, N.; Baquero, A.; Fonseca, G.; Harfoot, M.; Hilton-Taylor, C.; Kapos, V.; Ravilious, C.; Sayor, C.; Tallowin, O.; Sabita Teelucksingh, S.; Weatherdon, L.; Wyatt, S.
10.1101/2022.12.07.519459 — ecology — Posted on 2022-12-12
2554 Herbarium Specimen Sequencing Allows Precise Datation of Xanthomonas citri pv. citri Diversification History
Campos, P.; Pruvost, O.; Boyer, K.; Chiroleu, F.; Cao, T.-t.; Gaudeul, M.; Baider, C.; Utteridge, T.; Dominick, S.; Becker, N.; Rieux, A.; Gagnevin, L.
10.1101/2022.12.08.519547 — evolutionary biology — Posted on 2022-12-12
2556 Resolving intergenotypic Striga resistance in sorghum
Mutinda, S.; Maati, F. M.; Hale, B.; Dayou, O.; Ateka, E.; Wijeratne, A.; Wicke, S.; Bellis, E. S.; Runo, S.
10.1101/2022.12.08.519579 — plant biology — Posted on 2022-12-12
2558 Population divergence in maternal investment and embryo energy use and allocation reveals adaptive responses to cool climates
Pettersen, A. K.; Ruuskanen, S.; Nord, A.; Nilsson, J. F.; Ruiz Minano, M.; Fitzpatrick, L. J.; While, G. M.; Uller, T.
10.1101/2022.12.07.519527 — evolutionary biology — Posted on 2022-12-12
2559 A cosmopolitan inversion drives seasonal adaptation in overwintering Drosophila
Nunez, J. C. B.; Lenhart, B. A.; Bangerter, A.; Murray, C. S.; Yu, Y.; Nystrom, T. L.; Tern, C.; Erickson, P. A.; Bergland, A. O.
10.1101/2022.12.09.519676 — evolutionary biology — Posted on 2022-12-12
2560 Stromal resistance to castration-induced prostate regression in a mouse model of benign prostatic hyperplasia
Zhang, R.; Singh, S.; Pan, C.; Xu, B.; Kindblom, J.; Yeh, S.-Y.; Chang, C.; Eng, K. H.; Krolewski, J. J.; Nastiuk, K. L.
10.1101/2022.12.07.519520 — pathology — Posted on 2022-12-12
2564 Visualization of early RNA replication kinetics of SARS-CoV-2 by using single molecule RNA-FISH
Pathak, R.; Eliscovich, C.; Mena, I.; Dixit, U.; Garcia-Sastre, A.; Singer, R.; Kalpana, G. V.
10.1101/2022.12.10.517707 — microbiology — Posted on 2022-12-12
2568 Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture
Villeneuve, C.; Hashmi, A.; Ylivinkka, I.; Lawson-Keister, E.; Miroshnikova, Y. A.; Perez-Gonzalez, C.; Yadav, B.; Zhang, T.; Matic Vignjevic, D.; Mikkola, M. L.; Manning, L.; Wickstrom, S. A.
10.1101/2022.12.12.519937 — developmental biology — Posted on 2022-12-12
2570 Subcellular location defines GPCR signal transduction
Radoux-Mergault, A.; Oberhauser, L.; Aureli, S.; Gervasio, F. L.; Stoeber, M.
10.1101/2022.12.12.520050 — cell biology — Posted on 2022-12-12
2571 Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation
Lopez-Erauskin, J.; Bravo-Hernandez, M.; Presa, M.; Baughn, M. W.; Melamed, Z.; Beccari, M. S.; Agra de Almeida Quadros, A. R.; Zuberi, A.; Ling, K.; Platoshyn, O.; Nino-Jara, E.; Ndayambaje, I. S.; Arnold-Garcia, O.; McAlonis-Downes, M.; Cabrera, L.; Artates, J. W.; Ryan, J.; Bennett, F.; Jafar-nejad, P.; Rigo, F.; Marsala, M.; Lutz, C. M.; Cleveland, D. W.; Lagier-Tourenne, C.
10.1101/2022.12.11.519794 — cell biology — Posted on 2022-12-12
2573 Convergent adaptation of true crabs (Decapoda: Brachyura) to a gradient of terrestrial environments
Wolfe, J. M.; Ballou, L.; Luque, J.; Watson-Zink, V. M.; Ahyong, S. T.; Barido-Sottani, J.; Chan, T.-Y.; Chu, K. H.; Crandall, K. A.; Daniels, S. R.; Felder, D. L.; Mancke, H.; Martin, J. W.; Ng, P. K. L.; Ortega-Hernandez, J.; Palacios Theil, E.; Pentcheff, N. D.; Robles, R.; Thoma, B. P.; Tsang, L. M.; Wetzer, R.; Windsor, A. M.; Bracken-Grissom, H. D.
10.1101/2022.12.09.519815 — evolutionary biology — Posted on 2022-12-12
2575 CRISPR-Cas Controls Cryptic Prophages
Song, S.; Semenova, E.; Severinov, K.; Garcia, L. F.; Benedik, M. J.; Maeda, T.; Wood, T. K.
10.1101/2021.07.28.454074 — molecular biology — Posted on 2022-12-12
2577 Acetaminophen production in the edible, filamentous cyanobacterium Arthrospira platensis
Hilzinger, J. M.; Friedline, S.; Sivanandan, D.; Cheng, Y.-F.; Yamazaki, S.; Clark, D. S.; Skerker, J. M.; Arkin, A. P.
10.1101/2022.06.30.498297 — bioengineering — Posted on 2022-12-12
2578 Selection and adaptive introgression guided the complex evolutionary history of the European common bean
Bellucci, E.; Benazzo, A.; Xu, C.; Bitocchi, E.; Rodriguez, M.; Alseekh, S.; Di Vittori, V.; Gioia, T.; Neumann, K.; Cortinovis, G.; Frascarelli, G.; Murube, E.; Trucchi, E.; Nanni, L.; Ariani, A.; Logozzo, G.; Shin, J. H.; Liu, C.; Jiang, L.; Ferreira, J. J.; Campa, A.; Attene, G.; Morrell, P. L.; Bertorelle, G.; Graner, A.; Gepts, P.; Fernie, A. R.; Jackson, S. A.; Papa, R.
10.1101/2022.09.28.509856 — genomics — Posted on 2022-12-12
2583 CotH genes are necessary for normal spore formation and virulence in Mucor lusitanicus
Szebenyi, C.; Gu, Y.; Gebremariam, T.; Kocsube, S.; Kiss-Vetrab, S.; Jager, O.; Patai, R.; Spisak, K.; Sinka, R.; Binder, U.; Homa, M.; Vagvölgyi, C.; Ibrahim, A. S.; Nagy, G.; Papp, T.
10.1101/2022.12.09.519853 — microbiology — Posted on 2022-12-12
2584 Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease
Kulkarni, S.; Saha, M.; Slosberg, J.; Singh, A.; Nagaraj, S.; Becker, L. S.; Zhang, C.; Bukowski, A.; Wang, Z.; Liu, G.; Leser, J.; Kumar, M.; Bakhshi, S.; Anderson, M. J.; Lewandoski, M.; Vincent, E.; Goff, L.; Pasricha, P. J.
10.1101/2020.08.25.262832 — neuroscience — Posted on 2022-12-12
2587 SMRT-AgRenSeq-d in potato (Solanum tuberosum) identifies candidates for the nematode resistance Gpa5
Wang, Y.; Brown, L. H.; Adams, T. M.; Cheung, Y. W.; Li, J.; Young, V.; Todd, D. T.; Armstrong, M. R.; Neugebauer, K.; Kaur, A.; Harrower, B.; Oome, S.; Wang, X.; Bayer, M.; Hein, I.
10.1101/2022.12.08.519582 — plant biology — Posted on 2022-12-12
2589 Elephant trunks have an adaptable prehensile grip
Schulz, A. K.; Reidenberg, J.; Wu, J.; Tang, C. Y.; Seleb, B.; Mancebo, J.; Elgart, N.; Hu, D. L.
10.1101/2022.10.06.511214 — bioengineering — Posted on 2022-12-12
2590 De novo design of high-affinity protein binders to bioactive helical peptides
Vazquez Torres, S.; Leung, P. J. Y.; Lutz, I. D.; Venkatesh, P.; Watson, J. L.; Hink, F.; Huynh, H.-H.; Yeh, A. H.-W.; Juergens, D.; Bennett, N. R.; Hoofnagle, A. N.; Huang, E.; MacCoss, M. J.; Exposit, M.; Lee, G. R.; Korkmaz, E. N.; Nivala, J.; Stewart, L.; Rogers, J. M.; Baker, D.
10.1101/2022.12.10.519862 — bioengineering — Posted on 2022-12-12
2594 Visualization of loop extrusion by nanoscale 3D DNA tracing in single human cells
Beckwith, K. S.; Oedegaard Fougner, O.; Morero, N. R.; Barton, C.; Schueder, F.; Tang, W.; Alexander, S.; Peters, J.-M.; Jungmann, R.; Birney, E.; Ellenberg, J.
10.1101/2021.04.12.439407 — cell biology — Posted on 2022-12-12
2595 Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle
Nasir, N. J. M.; Heemskerk, H.; Jenkins, J. H.; Hamadee, N. H.; Bunte, R.; Tucker-Kellogg, L.
10.1101/2022.03.07.483146 — molecular biology — Posted on 2022-12-12
2596 Plasticity and lineage commitment of individual Th1 cells are determined by stable T-bet expression quantities
Hegazy, A. N.; Peine, C.; Niesen, D.; Panse, I.; Vainshtein, Y.; Kommer, C.; Zhang, Q.; Brunner, T. M.; Peine, M.; Froehlich, A.; Ishaque, N.; Marek, R. M.; Zhu, J. J.; Hoefer, T.; Loehning, M.
10.1101/2022.08.14.503916 — immunology — Posted on 2022-12-12
2599 NMDA receptor misalignment in iPSC-derivedneurons from a multi-generational family withinherited Creutzfeldt-Jakob disease
Le, N. T.; Mercer, R. C.; Gojanovich, A. D.; Anane, A.; Park, S.; Wu, B.; Bawa, P. S.; Genetics Center, R.; Mostoslavsky, G.; Harris, D. A.
10.1101/2022.05.20.491674 — neuroscience — Posted on 2022-12-12
2603 Resurrection of plant disease resistance proteins via helper NLR bioengineering
Contreras, M. P.; Pai, H.; Selvaraj, M.; Toghani, A.; Lawson, D. M.; Tumtas, Y.; Duggan, C.; Yuen, E. L. H.; Stevenson, C. E. M.; Harant, A.; Wu, C.-H.; Bozkurt, T. O.; Kamoun, S.; Derevnina, L.
10.1101/2022.12.11.519957 — plant biology — Posted on 2022-12-11
2605 Shear Stress Induces a Pro-Inflammatory Phenotype in Human Monocyte-Derived Macrophages
Jui, E.; Kingsley, G.; Pham, H. K.; Connell, J.; Keswani, S.; Grande-Allen, K. J.
10.1101/2022.12.08.519590 — bioengineering — Posted on 2022-12-11
2606 Missense variant interaction scanning reveals a critical role of the FERM-F3 domain for tumor suppressor protein NF2 conformation and function
Moesslacher, C. S.; Woodsmith, J.; Auernig, E.; Feichtner, A.; Jany-Luig, E.; Jehle, S.; Worseck, J. M.; Stefan, E.; Stelzl, U.
10.1101/2022.12.11.519953 — systems biology — Posted on 2022-12-11
2610 Focused ultrasound-mediated brain genome editing
Lao, Y.-H.; Ji, R.; Zhou, J. K.; Snow, K. J.; Kwon, N.; Saville, E.; He, S.; Chauhan, S.; Chi, C.-W.; Datta, M. S.; Zhang, H.; Quek, C. H.; Cai, S.; Li, M.; Gaitan, Y.; Bechtel, L.; Wu, S.-Y.; Lutz, C. M.; Tomer, R.; Murray, S. A.; Chavez, A.; Konofagou, E. E.; Leong, K. W.
10.1101/2022.12.10.519924 — bioengineering — Posted on 2022-12-11
2611 Genomic data suggest parallel dental vestigialization within the xenarthran radiation
Emerling, C. A.; Gibb, G. C.; Tilak, M.-K.; Hughes, J. J.; Kuch, M.; Duggan, A. T.; Poinar, H. N.; Nachman, M. W.; Delsuc, F.
10.1101/2022.12.09.519446 — evolutionary biology — Posted on 2022-12-11
2612 Inhibition of translation termination by Drosocin, an antimicrobial peptide from fruit flies
Mangano, K.; Klepacki, D.; Ohanmu, I.; Baliga, C.; Huang, W.; Brakel, A.; Krizsan, A.; Polikanov, Y. S.; Hoffmann, R.; Vazquez-Laslop, N.; Mankin, A. S.
10.1101/2022.12.11.519952 — molecular biology — Posted on 2022-12-11
2616 Sex-specific deubiquitylation drives immune-related neurodegeneration in Drosophila
Xia, J.; Pinto-Fernandez, A.; Damianou, A.; Lee, J.; Kessler, B. M.; Davis, I.; Elliott, P. R.; Ligoxygakis, P.
10.1101/2022.12.09.519782 — immunology — Posted on 2022-12-11
2617 Quinazoline-quinoline bisubstrate inhibitors target eukaryotic translation initiation factor 3 in Plasmodium falciparum
Dobrescu, I.; Hammam, E.; Dziekan, J. M.; Claës, A.; Halby, L.; Preiser, P.; Bozdech, Z.; Arimondo, P. B.; Scherf, A.; Nardella, F.
10.1101/2022.12.10.519887 — pharmacology and toxicology — Posted on 2022-12-11
2618 Synthesis and structural optimization of 2,7,9-trisubstituted purin-8-ones as FLT3-ITD inhibitors
Tomanova, M.; Kozlanska, K.; Jorda, R.; Jedinak, L.; Havlikova, T.; Reznickova, E.; Perina, M.; Klener, P.; Dolnikova, A.; Cankar, P.; Krystof, V.
10.1101/2022.12.10.519888 — pharmacology and toxicology — Posted on 2022-12-11
2619 Amoeba Predation of Cryptococcus: A Quantitative and Population Genomic Evaluation of the Accidental Pathogen Hypothesis
Sauters, T. J. C.; Roth, C.; Murray, D.; Sun, S.; Floyd-Averette, A. J. C.; Onyishi, C. U.; May, R. C.; Heitman, J.; Magwene, P. M.
10.1101/2022.12.08.519367 — genomics — Posted on 2022-12-11
2626 Circadian reprogramming of adipose progenitor cells regulates intermittent fasting-mediated adipose tissue remodeling and metabolic improvement
Lee, J. H.; Patel, Y.; Yeung, J. L.-H.; Pickel, L.; Ealey, K. N.; Togo, J.; Kim, Y.-H.; Kim, K.-H.; Park, J.-G.; Jackson, T.; Okrainec, A.; Kim, J.-R.; Park, S.-Y.; Dash, S.; Sung, H.-K.
10.1101/2022.12.10.519916 — molecular biology — Posted on 2022-12-11
2627 The SUMO-interacting Motif in NS2 promotes adaptation of avian influenza virus to mammals
Sun, L.; Kong, H.; Yu, M.; Zhang, Z.; Zhang, H.; Na, L.; Qu, Y.; Zhang, Y.; Chen, H.; Wang, X.
10.1101/2022.12.11.519849 — microbiology — Posted on 2022-12-11
2628 From whole genome to probiotic candidates: a study of potential Lactobacillus strain selection for vaginitis treatment
Lyu, J.; Gao, M.; Zhao, S.; Lyu, X.; Zhao, X.; Zou, Y.; Zhong, Y.; Ge, L.; Zhang, H.; Xiao, L.; Zhang, X.
10.1101/2022.12.11.519948 — microbiology — Posted on 2022-12-11
2629 Single-cell profiling identifies clinically relevant interactions between tumor associated macrophages and blood endothelial cells in diffuse large B cell lymphoma
Ferrant, J.; Le Gallou, S.; Padonou, F.; Leonard, S.; Papa, I.; Pangault, C.; Barthel, A.; Launay, V.; Manson, G.; Hoareau, B.; Deleurme, L.; Monvoisin, C.; Albaud, B.; Van Acker, N.; Laurent, C.; Llamas Gutierrez, F.; Michaud, H. A.; Bonnefoy, N.; Pecot, T.; Tarte, K.; Roussel, M.
10.1101/2022.12.08.519637 — immunology — Posted on 2022-12-11
2630 Directed evolution of generalist biosensors for single ring aromatics
Cole, H.; Kosonocky, C. W.; Schechter, M.; Gollihar, J. D.; Ellington, A.; d'Oelsnitz, S.
10.1101/2022.12.11.519963 — synthetic biology — Posted on 2022-12-11
2631 Propagated circulating tumor cells uncovers the rople of NFκB and COP1 in metastasis
Xiao, J.; Sharma, U.; Arab, A.; Miglani, S.; Bhalla, S.; Suguru, S.; Suter, R.; Mukherji, R.; Lippman, M. E.; Pohlmann, P. R.; Zeck, J.; Marshall, J. L.; Weinberg, B. A.; He, A. R.; Noel, M. S.; Schlegel, R.; Goodarzi, H.; Agarwal, S.
10.1101/2022.12.09.519805 — cancer biology — Posted on 2022-12-11
2633 Regulation of Nuclear Transcription by Mitochondrial RNA
Sriram, K.; Qi, Z.; Yuan, D.; Malhi, N. K.; Liu, X.; Calandrelli, R.; Luo, Y.; Jin, S.; Shi, J.; Salas, M.; Dang, R.; Armstrong, B.; Priceman, S. J.; Wang, P.; Liao, J.; Natarajan, R.; Zhong, S.; Chen, Z. B.
10.1101/2022.12.10.519922 — genomics — Posted on 2022-12-11
2634 How woodcocks produce the most brilliant white plumage patches among the birds
Dunning, J.; Patil, A.; Bond, A.; D'Alba, L.; Debruyn, G.; Dhinojwala, A.; Shawkey, M.; Jenni, L.
10.1101/2022.12.09.519795 — ecology — Posted on 2022-12-11
2636 Mesenchymal Progenitors set the homeostatic inflammatory milieu via the TAK1-NFkB axis.
Theret, M.; Messing, M.; White, Z.; Henry, L. W.; Rempel, L.; Hamer, M.; Hashimoto, J.; Li, F. F.; Brassard, J.; Li, Y.; Sauge, E.; Shin, S.; Day, K.; Uppal, M.; Low, M.; Eisner, C.; Sato, S.; Akira, S.; Bernatchez, P.; McNagny, K.; Rossi, F. M. V.
10.1101/2022.12.11.519940 — cell biology — Posted on 2022-12-11
2637 Cleavage of the Jaw1 C-terminal region enhances its augmentative effect on the Ca2+ release via inositol 1,4,5-trisphosphate receptors
Kozono, T.; Jogano, C.; Okumura, W.; Sato, H.; Matsui, H.; Takagi, T.; Okumura, N.; Takao, T.; Tonozuka, T.; Nishikawa, A.
10.1101/2022.12.10.519934 — cell biology — Posted on 2022-12-11
2640 Supercomputers and Reverse Engineering of Motoneuron Firing Patterns
Chardon, M. K.; Wang, Y. C.; Garcia, M.; Besler, E.; Beauchamp, J. A.; D'Mello, M.; Powers, R. K.; Heckman, C. J.
10.1101/2022.12.09.519818 — neuroscience — Posted on 2022-12-11
2641 "Paradoxical wakefulness" induced by psychedelic 5-methoxy-N,N-dimethyltryptamine in mice
Breant, B. J.; Prius Mengual, J.; Bannerman, D. M.; Sharp, T.; Vyazovskiy, V. V.
10.1101/2022.12.11.519886 — neuroscience — Posted on 2022-12-11
2642 Patient-derived tumoroids of advanced high-grade neuroendocrine neoplasms mimic patient chemotherapy responses and guide the design of personalized combination therapies
April-Monn, S. L.; Detjen, K.; Kirchner, P.; Braeutigam, K.; Trippel, M. A.; Marques, I. J.; Grob, T.; Statzer, C.; Maire, R. S.; Kollar, A.; Chouchane, A.; Kunze, K.; Horst, D.; Sadowski, M. C.; Schrader, J.; Mercader, N.; Marinoni, I.; Wiedenmann, B.; Perren, A.
10.1101/2022.12.10.519855 — cancer biology — Posted on 2022-12-11
2643 m6A modification of TERRA RNA is required for telomere maintenance and is a therapeutic target for ALT positive Neuroblastoma
Vaid, R.; Thombare, K.; Mendez, A.; Burgos-Panadero, R.; Djos, A.; Jachimowicz, D.; Bartenhagen, C.; Kumar, N.; Sihlbom, C.; Fransson, S.; Johnsen, J. I.; Kogner, P.; Martinsson, T.; Fischer, M.; Mondal, T.
10.1101/2022.12.09.519591 — cancer biology — Posted on 2022-12-11
2644 Multiomic Profiling Reveals Metabolic Alterations Mediating Aberrant Platelet Activity and Inflammation in Myeloproliferative Neoplasms
He, F.; Laranjeira, A. B. A.; kong, t.; Liu, A.; Bark, K.; Lasky, N. M.; Fisher, D. A. C.; Cox, M. J.; Fulbright, M.; Yu, L.; Sykes, S. M.; DAlessandro, A.; Di Paola, J.; Oh, S.
10.1101/2022.12.08.519689 — cancer biology — Posted on 2022-12-11
2645 Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma
Tarantino, G.; Ricker, C. A.; Wang, A.; Ge, W.; Aprati, T. J.; Huang, A. Y.; Madha, S.; Chen, J.; Shi, Y.; Glettig, M.; Frederick, D. T.; Freeman, S.; Holovatska, M. M.; Manos, M. P.; Zimmer, L.; Roesch, A.; Zaremba, A.; Reardon, B.; Park, J.; Elmarakeby, H. A.; Schilling, B.; Giobbie-Hurder, A.; Vokes, N. I.; Buchbinder, E. I.; Flaherty, K. T.; Haq, R.; Wu, C. J.; Boland, G. M.; Hodi, F. S.; Van Allen, E. M.; Schadendorf, D.; Liu, D.
10.1101/2022.12.11.519808 — cancer biology — Posted on 2022-12-11
2647 The OSUMMER lines: a series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6
Murphy, B. M.; Jensen, D. M.; Arnold, T. E.; Aguilar Valenzuela, R.; Hughes, J.; Posada, V.; Nguyen, K. T.; Chu, V. T.; Tsai, K. Y.; Burd, C. J.; Burd, C. E.
10.1101/2022.12.09.519766 — cancer biology — Posted on 2022-12-11
2648 Molecular determinants of inhibition of UCP1-mediated respiratory uncoupling
Gagelin, A.; Largeau, C.; Masscheleyn, S.; Piel, M.; Calderon-Mora, D.; Bouillaud, F.; Henin, J.; Miroux, B.
10.1101/2022.12.09.516457 — biophysics — Posted on 2022-12-11
2649 Fine spectral tuning of a flavin-binding fluorescent protein for multicolor imaging
Nikolaev, A.; Yudenko, A.; Smolentseva, A.; Bogorodskiy, A.; Tsybrov, F.; Borshchevskiy, V.; Bukhalovich, S.; Nazarenko, V. V.; Kuznetsova, E.; Semenov, O.; Remeeva, A.; Gushchin, I.
10.1101/2022.12.09.519645 — biophysics — Posted on 2022-12-11
2653 TRAP1 S-nitrosylation as a model of population-shift mechanism to study the effects of nitric oxide on redox-sensitive oncoproteins.
Papaleo, E.; Tiberti, M.; Arnaudi, M.; Pecorari, C.; Faienza, F.; Cantwell, L.; Degn, K.; Pacello, F.; Battistoni, A.; Lambrughi, M.; Filomeni, G.
10.1101/2022.12.11.519943 — biochemistry — Posted on 2022-12-11
2655 Genetically engineered mesenchymal stem cells as a nitric oxide reservoir for acute kidney injury therapy
Huang, H.; Qian, M.; Liu, Y.; Chen, S.; Li, H.; Han, Z.; Han, Z.-c.; Chen, X.; Zhao, Q.; Li, Z.
10.1101/2022.12.11.519950 — biochemistry — Posted on 2022-12-11
2661 Transgenic porcine model reveals two roles for LGR5 during lung development and homeostasis
Polkoff, K.; Gupta, N. K.; Murphy, Y.; Lampe, R.; Chung, J.; Carter, A.; Simon, J. M.; Moatti, A.; Kadur Lakshminarasimha Murthy, P.; Gleason, K.; Edwards, L.; Greenbaum, A.; Tata, A.; Tata, P. R.; Piedrahita, J. A.
10.1101/2022.12.09.516617 — cell biology — Posted on 2022-12-11
2664 Vimo: Visual Analysis of Neuronal Connectivity Motifs
Troidl, J.; Warchol, S.; Choi, J.; Matelsky, J.; Dhanysai, N.; Wang, X.; Wester, B.; Wei, D.; Lichtman, J. W.; Pfister, H.; Beyer, J.
10.1101/2022.12.09.519772 — neuroscience — Posted on 2022-12-11
2665 An in vivo platform for rebuilding functional neocortical tissue
Quezada, A.; Ward, C.; Bader, E. R.; Zolotavin, P.; Altun, E.; Hong, S.; Killian, N.; Xie, C.; Batista-Brito, R.; Hebert, J. M.
10.1101/2022.12.09.519776 — neuroscience — Posted on 2022-12-11
2666 Evaluation of the Efficacy of the Hypocretin/orexin Receptor Agonists TAK-925 and ARN-776 in Narcoleptic Orexin/tTA; TetO-DTA Mice
Sun, Y.; Ranjan, A.; Tisdale, R. K.; Park, S.; Ma, S.-C.; Haire, M.; Heu, J.; Morairty, S. R.; Wang, X.; Rosenbaum, D.; Williams, N. S.; De Brabander, J.; Kilduff, T. S.
10.1101/2022.12.09.519796 — neuroscience — Posted on 2022-12-11
2672 Targeting TR4-induced RCC cells-derived exosomally initiated signaling increases Sunitinib efficacy
Wang, Z.; Sun, Y.; Xu, H.; Huang, C.; Cheng, B.; Chou, F.; You, B.; Qiu, X.; Yang, G.; Chang, C.
10.1101/2022.12.07.519440 — cancer biology — Posted on 2022-12-11
2674 On the origin and evolution of the mosquito male-determining factor Nix
Biedler, J. K.; Aryan, A.; Qi, Y.; Wang, A.; Martinson, E. O.; Hartman, D.; Yang, F.; Sharma, A.; Morton, K.; Potters, M.; Chen, C.; Dobson, S. L.; Ebel, G.; Kading, R. C.; Paulson, S.; Xue, R.-D.; Strand, M. R.; Tu, Z.
10.1101/2022.12.07.519398 — evolutionary biology — Posted on 2022-12-11
2675 Capturing long-tailed individual tree diversity using an airborne multi-temporal hierarchical model
Weinstein, B.; Marconi, S.; Graves, S.; Zare, A.; Singh, A.; Bohlman, S.; Magee, L.; Johnson, D.; Townsend, P.; White, E.
10.1101/2022.12.07.519493 — ecology — Posted on 2022-12-11
2676 High-resolution app data reveal sustained increases in recreational fishing effort in Europe during and after COVID-19 lockdowns
Audzijonyte, A.; Gonzalez, F. M.; Dainys, J.; Gundelund, C.; Skov, C.; DeWeber, J. T.; Venturelli, P. A.; Vienozinskis, V.; Smith, C.
10.1101/2022.12.07.519488 — ecology — Posted on 2022-12-11
2678 Insights into the evolution of herbivory from a leaf-mining, drosophilid fly
Aguilar, J. M.; Gloss, A. D.; Suzuki, H. C.; Verster, K. I.; Singhal, M.; Hoff, J.; Grebenok, R.; Nabity, P. D.; Behmer, S. T.; Whiteman, N. K.
10.1101/2022.12.07.519390 — ecology — Posted on 2022-12-11
2679 Latitude influences stability via stabilizing mechanisms in naturally-assembled forest ecosystems at different spatial grains
Zhou, T.; Craven, D.; Kreft, H.; Zhang, J.; Wang, X.; Lian, J.; Ye, W.; Jin, G.; Mi, X.; Yao, Y.; Ren, H.; Yang, J.; Cao, M.; Wang, C.; Qin, Y.; Zhou, G.; Fei, Y.; Xu, Y.; Qiao, X.; Jiang, M.; Guerrero-Ramirez, N. R.
10.1101/2022.12.07.519439 — ecology — Posted on 2022-12-11
2680 Structural basis for BIRC6 to balance apoptosis and autophagy
Liu, S.; Jiang, T.; Bu, F.; Zhao, J.; Wang, G.; Yang, G.; Kong, J.; Qie, Y.; Wen, P.; Fan, L.; Li, N.; Gao, N.; Qiu, X.
10.1101/2022.12.10.519866 — cell biology — Posted on 2022-12-11
2681 Improving the detection of A. cantonensis in brain tissues of mammalian hosts
Arango-Colonna, M. A.; Delgado-Serra, S.; Haines, L.; Paredes-Esquivel, C.
10.1101/2022.12.07.518866 — zoology — Posted on 2022-12-11
2684 Spateo: multidimensional spatiotemporal modeling of single-cell spatial transcriptomics
Qiu, X.; Zhu, D. Y.; Yao, J.; Jing, Z.; Zuo, L.; Wang, M.; Min, K. H.; Pan, H.; Wang, S.; Liao, S.; Lai, Y.; Hao, S.; Lu, Y. R.; Hill, M.; Martin-Rufino, J. D.; Weng, C.; Riera-Escandell, A. M.; Chen, M.; Wu, L.; Zhang, Y.; Wei, X.; Li, M.; Huang, X.; Xiang, R.; Yang, Z.; Liu, C.; Xia, T.; Liang, Y.; Xu, J.; Hu, Q.; Hu, Y.; Zhu, H.; Li, Y.; Chen, A.; Esteban, M. A.; Gu, Y.; Lauffenburger, D. A.; Xu, X.; Liu, L.; Weissman, J. S.; Liu, S.; Bai, Y.
10.1101/2022.12.07.519417 — systems biology — Posted on 2022-12-11
2688 Modelling metastasis in zebrafish unveils regulatory interactions of cancer-associated fibroblasts with circulating tumour cells
Hurtado, P.; Martinez-Pena, I.; Yepes-Rodriguez, S.; Bascoy-Otero, M.; Abuin, C.; Fernandez-Santiago, C.; Sanchez, L.; Lopez-Lopez, R.; Pineiro, R.
10.1101/2022.12.07.519426 — cancer biology — Posted on 2022-12-11
2689 Dalpiciclib Partially Abrogates ER Signaling Activation Induced by Pyrotinib In HER2+HR+ Breast Cancer
Liu, C.; Bu, J.; Zhang, Y.; Niu, N.; Bi, K.; Sun, L.; Qiao, X.; Wang, Y.; Zhang, Y.; Jiang, X.; Wang, D.; Ma, Q.; Li, H.
10.1101/2022.12.07.519433 — cancer biology — Posted on 2022-12-11
2691 Target Recycling Amplification Process for Digital Detection of Exosomal MicroRNAs Through Photonic Resonator Absorption Microscopy
Wang, X.; Shepherd, S.; Li, N.; Che, C.; Song, T.; Xiong, Y.; Palm, I. R.; Zhao, B.; Kohli, M.; Demirci, U.; Lu, Y.; Cunningham, B.
10.1101/2022.12.07.519503 — bioengineering — Posted on 2022-12-11
2693 TLS2trees: a scalable tree segmentation pipeline for TLS data
Wilkes, P.; Disney, M. I.; Armston, J.; Bartholomeus, H.; Bentley, L. P.; Brede, B.; Burt, A.; Calders, K.; Chavana-Bryant, C.; Clewley, D.; Duncanson, L.; Forbes, B.; Krisanski, S.; Malhi, Y.; Moffat, D.; Origo, N.; Shenkin, A.; Yang, W.
10.1101/2022.12.07.518693 — ecology — Posted on 2022-12-11
2696 Genomic, Functional and Structural Analyses Reveal Mechanisms of Evolutionary Innovation within the Sea Anemone 8 Toxin Family
Ashwood, L. M.; Elnahriry, K. A.; Stewart, Z. K.; Shafee, T.; Naseem, M. U.; Szanto, T. G.; van der Burg, C. A.; Smith, H. L.; Surm, J. M.; Undheim, E. A. B.; Madio, B.; Hamilton, B. R.; Guo, S.; Wai, D. C. C.; Coyne, V. L.; Phillips, M. J.; Dudley, K. J.; Hurwood, D. A.; Panyi, G.; King, G. F.; Pavasovic, A.; Norton, R. S.; Prentis, P. J.
10.1101/2022.12.08.518931 — genetics — Posted on 2022-12-11
2699 On the Mechanisms of Audio-Visual Integration for Manual Interception
Kreyenmeier, P.; Schroeger, A.; Canal-Bruland, R.; Raab, M.; Spering, M.
10.1101/2022.12.09.519832 — neuroscience — Posted on 2022-12-11
2700 Bulk and Mosaic Deletions of Egfr Reveal Regionally Defined Gliogenesis in the Developing Mouse Forebrain
Zhang, X.; Xiao, G.; Johnson, C. A.; Cai, Y.; Horowitz, Z.; Mennicke, C.; Coffey, R.; Haider, M.; Threadgill, D. W.; Eliscu, R.; Oldham, M. C.; Greenbaum, A. C.; Ghashghaei, H. T.
10.1101/2022.12.10.519926 — neuroscience — Posted on 2022-12-11
2703 The role of human superior colliculus in affective experiences during visual and somatosensory stimulation
Chen, D.; Kragel, P. A.; Savoca, P. W.; Wald, L. L.; Bianciardi, M.; Wager, T. D.; Quigley, K. S.; Satpute, A. B.; Barrett, L. F.; Theriault, J. E.
10.1101/2022.12.09.519812 — neuroscience — Posted on 2022-12-11
2705 Template-Directed RIG-I Agonist Assembly for Targeted Cancer Immunotherapy
Ghosh, S. K.; Robertson, N.; Crosier, E.; Dudley, M.; Liu, Q. P.; Medarova, Z.
10.1101/2022.12.08.519592 — bioengineering — Posted on 2022-12-10
2708 RecA balances genomic stability and evolution using many successive mismatch tolerant homology tests
PRENTISS, M.; Wang, D.; Fu, J.; Prevost, C.; Godoy, V.; Kleckner, N. E.; Danilowicz, C.
10.1101/2022.12.09.519633 — biophysics — Posted on 2022-12-10
2710 Inhibiting POLQ-mediated alternative NHEJ enhances CRISPR/Cas9 mediated precise genome editing in CHO cells
Wang, C.; Wang, M.; Zhang, M.; Wang, Y.; Li, X.; Liu, C.; Fan, R.; Zheng, Y.; Shen, B.; Sun, Z.; Wang, J.; Feng, J.
10.1101/2022.12.09.519421 — bioengineering — Posted on 2022-12-10
2713 Ocean currents drive the worldwide colonization of the most widespread marine plant, eelgrass (Zostera marina)
Yu, L.; Khachaturyan, M.; Matschiner, M.; Healey, A.; Bauer, D.; Cameron, B.; Cusson, M.; Duffy, J. E.; Fodrie, F. J.; Gill, D.; Grimwood, J.; Hori, M.; Hovel, K.; Hughes, A. R.; Jahnke, M.; Jenkins, J.; Keymanesh, K.; Kruschel, C.; Mamidi, S.; Moksnes, P.-O.; Nakaoka, M.; Pennacchio, C.; Reiss, K.; Rossi, F.; Ruesink, J. L.; Schultz, S.; Talbot, S.; Unsworth, R.; Schmutz, J.; Dagan, T.; Stachowicz, J. J.; Van de Peer, Y.; Olsen, J. L.; Reusch, T. B. H.
10.1101/2022.12.10.519859 — evolutionary biology — Posted on 2022-12-10
2714 Genetically encoded multimeric tags for intracellular protein localisation in cryo-EM
Fung, H. K.; Hayashi, Y.; Salo, V. T.; Babenko, A.; Zagoriy, I.; Brunner, A.; Ellenberg, J.; Mueller, C. W.; Cuylen-Haering, S.; Mahamid, J.
10.1101/2022.12.10.519870 — cell biology — Posted on 2022-12-10
2716 Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge
Oyong, D. A.; Duffy, F. J.; Neal, M. L.; Du, Y.; Carnes, J.; Schwedhelm, K. V.; Hertoghs, N.; Jun, S.-H.; Miller, H.; Aitchison, J. D.; De Rosa, S. C.; Newell, E. W.; McElrath, M. J.; McDermott, S. M.; Stuart, K. D.
10.1101/2022.12.09.519706 — immunology — Posted on 2022-12-10
2717 SMRT-AgRenSeq-d in potato (Solanum tuberosum) identifies candidates for the nematode resistance Gpa5
Wang, Y.; Brown, L. H.; Adams, T. M.; Cheung, Y. W.; Li, J.; Young, V.; Todd, D. T.; Armstrong, M. R.; Neugebauer, K.; Kaur, A.; Harrower, B.; Oome, S.; Wang, X.; Bayer, M.; Hein, I.
10.1101/2022.12.08.519582 — plant biology — Posted on 2022-12-10
2719 Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas
Wang, J. Z.; Patil, V.; Liu, J.; Dogan, H.; Behling, F.; Skardelly, M.; Tatagiba, M.; Hoffman, E.; Bunda, S.; Yakubov, R.; Kaloti, R.; Brandner, S.; Gao, A.; Cohen-Gadol, A.; Barnholtz-Sloan, J.; Raleigh, D.; Sahm, F.; Boutros, P. C.; Tabatabai, G.; Aldape, K.; Nassiri, F.; Zadeh, G.; International Consortium on Meningiomas (ICOM),
10.1101/2022.12.07.519545 — cancer biology — Posted on 2022-12-10
2722 Whole slide image representation in bone marrow cytology
Mu, Y.; Tizhoosh, H. R.; Dehkharghanian, T.; Campbell, C. J. V.
10.1101/2022.12.06.519318 — bioinformatics — Posted on 2022-12-10
2723 Multiplex profiling of developmental enhancers with quantitative, single-cell expression reporters
Lalanne, J.-B.; Regalado, S. G.; Domcke, S.; Calderon, D.; Martin, B.; Li, T.; Suiter, C. C.; Lee, C.; Trapnell, C.; Shendure, J. A.
10.1101/2022.12.10.519236 — genomics — Posted on 2022-12-10
2724 Genomic, Functional and Structural Analyses Reveal Mechanisms of Evolutionary Innovation within the Sea Anemone 8 Toxin Family
Ashwood, L. M.; Elnahriry, K. A.; Stewart, Z. K.; Shafee, T. M.; Naseem, M. U.; Szanto, T. G.; van der Burg, C. A.; Smith, H. L.; Surm, J. M.; Undheim, E. A. B.; Madio, B.; Hamilton, B. R.; Guo, S.; Wai, D. C. C.; Coyne, V. L.; Philips, M. J.; Dudley, K. J.; Hurwood, D. A.; Panyi, G.; King, G. F.; Pavasovic, A.; Norton, R. S.; Prentis, P. J.
10.1101/2022.12.08.518931 — genetics — Posted on 2022-12-10
2727 Detecting the ecological footprint of selection
Luiselli, J.; Overcast, I.; Rominger, A.; Ruffley, M.; Morlon, H.; Rosindell, J.
10.1101/2021.05.11.442553 — ecology — Posted on 2022-12-10
2730 Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India
Kumar, N.; Barua, S.; Kumar, R.; Khandelwal, N.; Kumar, A.; Verma, A.; Singh, L.; Godara, B.; Chander, Y.; Riyesh, T.; Sharma, D. K.; Pathak, A.; Kumar, S.; Dedar, R. K.; Mehta, V.; Gaur, M.; Bhardwaj, B.; Vyas, V.; Chaudhary, S.; Yadav, V.; Bhati, A.; Kaul, R.; Bashir, A.; Andrabi, A.; Yousuf, R. W.; Koul, A.; Kachhawa, S.; Gurav, A.; Gautam, S.; Tiwari, H. A.; Gupta, M. K.; Kumar, R.; Misri, J.; Kumar, A.; Mohanty, A. K.; Nandi, S.; Singh, K. P.; Pal, Y.; Dutt, T.; Tripathi, B. N.
10.1101/2022.12.10.519851 — microbiology — Posted on 2022-12-10
2733 Robin's Viewer: Using Deep-Learning Predictions to Assist EEG Annotation
Weiler, R.; Diachenko, M.; Juarez-Martinez, E.; Avramiea, A.-E.; Bloem, P.; Linkenkaer-Hansen, K.
10.1101/2022.08.07.503090 — neuroscience — Posted on 2022-12-10
2735 Proximity labelling allows to study novel factors in chloroplast development
Wurzinger, B.; Stael, S.; Leonardelli, M.; Perolo, C.; Melzer, M.; Chaturvedi, P.; Afjehi-Sadat, L.; Weckwerth, W.; Teige, M.
10.1101/2022.12.08.519630 — plant biology — Posted on 2022-12-10
2739 Monomer and dimer structures of cytochrome bo3 ubiquinol oxidase from Escherichia coli
Guo, Y.; Karimullina, E.; Emde, T.; Otwinowski, Z.; Borek, D.; Savchenko, A.
10.1101/2022.12.09.519786 — biophysics — Posted on 2022-12-10
2742 De novo design of high-affinity protein binders to bioactive helical peptides
Vazquez Torres, S.; Leung, P. J. Y.; Lutz, I. D.; Venkatesh, P.; Watson, J. L.; Hink, F.; Huynh, H.-H.; Yeh, A. H.-W.; Juergens, D.; Bennett, N. R.; Hoofnagle, A. N.; Huang, E.; MacCoss, M. J.; Exposit, M.; Lee, G. R.; Korkmaz, E. N.; Nivala, J.; Stewart, L.; Rodgers, J. M.; Baker, D.
10.1101/2022.12.10.519862 — bioengineering — Posted on 2022-12-10
2743 The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A
Munoz-Reyes, D.; McClelland, L. J.; Arroyo-Urea, S.; Sanchez-Yepes, S.; Sabin, J.; Perez-Suarez, S.; Menendez, M.; Mansilla, A.; Garcia-Nafria, J.; Sprang, S. R.; Sanchez-Barrena, M. J.
10.1101/2022.12.09.519724 — biochemistry — Posted on 2022-12-10
2747 Predictors of genomic diversity within North American squamates
Larkin, I. E.; Myers, E. A.; Carstens, B. C.; Barrow, L. N.
10.1101/2022.07.20.500845 — genomics — Posted on 2022-12-10
2749 Zinc and laboratory emerge date impact honey bee gut microbiota and survival
Soares, K. O.; Ricke, D.; Oliveira, C. J. B.; Lima, M. V.; Mrofchak, R.; Rodrigues, A. E.; Madden, C.; Johnson, R.; Hale, V. L.
10.1101/2022.12.07.519529 — ecology — Posted on 2022-12-10
2754 Fingerprint SRS Imaging Unveils Ergosteryl Ester as a Metabolic Signature of Azole-Resistant Candida albicans
Zhang, M.; Dong, P.-T.; Eldesouky, H. E.; Zhan, Y.; Lin, H.; Wang, Z.; Salama, E. A.; Jusuf, S.; Zong, C.; Chen, Z.; Seleem, M. N.; Cheng, J.-X.
10.1101/2022.12.09.519679 — microbiology — Posted on 2022-12-10
2755 Sensing the Full Dynamics of the Human Hand with a Neural Interface and Deep Learning
Simpetru, R.; Arkudas, A.; Braun, D.; Osswald, M.; Oliveira, D. S.; Eskofier, B.; Kinfe, T. M.; Del Vecchio, A.
10.1101/2022.07.29.502064 — neuroscience — Posted on 2022-12-10
2757 Cell projection plots: a novel visualization of bone marrow aspirate cytology
Dehkharghanian, T.; Mu, Y.; Ross, C.; Sur, M.; Tizhoosh, H. R.; Campbell, C. J. V.
10.1101/2022.12.06.519348 — pathology — Posted on 2022-12-10
2766 Leptospermum extract (QV0) suppresses pleural mesothelioma tumour growth in vitro and in vivo by mitochondrial dysfunction associated apoptosis
Shi, H.; Zhang, L.; Yu, T.-K.; Ke, H.; Johnson, B.; Rath, E.; Lee, K.; Klebe, S.; Kao, S.; Qin, K. L.; Pham, H. N. T.; Vuong, Q.; Cheng, Y.
10.1101/2022.12.06.519377 — cancer biology — Posted on 2022-12-10
2767 Emergent dynamics of underlying regulatory network links EMT and androgen receptor-dependent resistance in prostate cancer
Jindal, R.; Nanda, A.; Pillai, M.; Ware, K.; Singh, D.; Sehgal, M.; Armstrong, A.; Somarelli, J.; Jolly, M. K.
10.1101/2022.12.06.516625 — cancer biology — Posted on 2022-12-10
2770 Integrated Single-Dose Kinome Profiling Data is Predictive of Cancer Cell Line Sensitivity to Kinase Inhibitors
Joisa, C. U.; Chen, K. A.; Berginski, M. E.; Golitz, B. T.; Jenner, M. R.; Loeza, S. G. H.; Yeh, J. J.; Gomez, S. M.
10.1101/2022.12.06.519165 — bioinformatics — Posted on 2022-12-10
2779 The impact of sex and physical activity on the local immune response to muscle pain
Lesnak, J. B.; Hayashi, K.; Plumb, A. N.; Janowski, A. J.; Chimenti, M. S.; Sluka, K. A.
10.1101/2022.12.07.519473 — immunology — Posted on 2022-12-10
2781 Novel Peptide Inhibitor of Human Tumor Necrosis Factor-α has Antiarthritic Activity
Sahu, D.; Gupta, C.; Yennamalli, R.; Sharma, S.; Roy, S.; Hasan, S.; Gupta, P.; Sharma, V. K.; Kashyap, S.; Kumar, S.; Dwivedi, V. P.; Panda, A. K.; Das, H. R.; Liu, C.-J.
10.1101/2022.12.06.519274 — immunology — Posted on 2022-12-10
2785 General stain deconvolution of histopathology images with physics-guided deep learning
Chen, J.; Liu, L. Y.; Han, W.; Wang, D.; Cheung, A. M.; Tsui, H.; Martel, A. L.
10.1101/2022.12.06.519385 — bioinformatics — Posted on 2022-12-10
2788 De Novo Variants in MRTFB have gain of function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features.
Andrews, J. C.; Mok, J.-W.; Kanca, O.; Jangam, S.; Tifft, C.; Macnamara, E. F.; Russel, B.; Wang, L.-K.; Undiagnosed Diseases Network, ; Nelson, S. F.; Bellen, H. J.; Yamamoto, S.; Malicdan, M.; Wangler, M. F.
10.1101/2022.12.06.518921 — genetics — Posted on 2022-12-10
2790 SARS-CoV-2 exposure in Norway rats (Rattus norvegicus) from New York City
Wang, Y.; Lenoch, J.; Kohler, D.; DeLiberto, T.; Tang, C.; Li, T.; Tao, Y.; Guan, M.; Compton, S.; Zeiss, C. J.; Hang, J.; Wan, X.-F.
10.1101/2022.11.18.517156 — microbiology — Posted on 2022-12-10
2792 Coupling of perinuclear actin cap and nuclear mechanics regulates flow-induced YAP spatiotemporal nucleocytoplasmic transport
Ma, T.; Liu, X.; Su, H.; Li, S.; Gao, C.; Liang, Z.; Zhang, D.; Zhang, X.; Li, K.; Hu, K.; Wang, L.; Wang, M.; Wu, F.; Yue, S.; Hong, W.; Chen, X.; Deng, X.; Wang, P.; Fan, Y.
10.1101/2022.11.15.516697 — bioengineering — Posted on 2022-12-10
2794 Context-dependent functions of mitochondria protein quality control in lung
Xu, L.; Tan, C.; Barr, J.; Talaba, N.; McCulley, D.; Shen, Y.; Chung, W. K.; Sun, X.
10.1101/2022.12.08.519642 — cell biology — Posted on 2022-12-10
2795 A Host-Harbored Metabolic Susceptibility of Coronavirus Enables Broad-Spectrum Targeting
Fang, H.; Wang, Y.; Liu, L.; Cheng, K.; Li, P.; Tan, Y.; Hao, X.; Mei, M.; Xu, X.; Yao, Y.; Zan, F.; Wu, L.; Zhu, Y.; Xu, B.; Huang, D.; Wang, C.; Tan, X.; Qian, Z.; Chen, X.-W.
10.1101/2022.12.07.519404 — cell biology — Posted on 2022-12-10
2796 Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing
Doherty, L.; Wan, M.; Peterson, A.; Youngstrom, D. W.; King, J. S.; Kalajzic, I.; Hankenson, K. D.; Sanjay, A.
10.1101/2022.12.09.519810 — cell biology — Posted on 2022-12-10
2797 Primary Cilia are WNT Transducing Organelles whose Biogenesis is Regulated by a WNTPP1 axis
Zhang, K.; Da Silva, F.; Seidl, C.; Wilsch-Bräuninger, M.; Herbst, J.; Huttner, W. B.; Niehrs, C.
10.1101/2022.12.09.519813 — cell biology — Posted on 2022-12-10
2799 Protein-protein interactions in the Mla lipid transport system probed by computational structure prediction and deep mutational scanning
MacRae, M. R.; Puvanendran, D.; Haase, M. A. B.; Coudray, N.; Kolich, L. R.; Lam, C.; Baek, M.; Bhabha, G.; Ekiert, D. C.
10.1101/2022.12.09.519820 — biophysics — Posted on 2022-12-10
2801 Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models
Watson, J. L.; Juergens, D.; Bennett, N. R.; Trippe, B. L.; Yim, J.; Eisenach, H. E.; Ahern, W.; Borst, A. J.; Ragotte, R. J.; Milles, L. F.; Wicky, B. I. M.; Hanikel, N.; Pellock, S. J.; Courbet, A.; Sheffler, W.; Wang, J.; Venkatesh, P.; Sappington, I.; Vazquez Torres, S.; Lauko, A.; De Bortoli, V.; Mathieu, E.; Barzilay, R.; Jaakkola, T. S.; DiMaio, F.; Baek, M.; Baker, D.
10.1101/2022.12.09.519842 — biochemistry — Posted on 2022-12-10
2804 Core PCP mutations affect short time mechanical properties but not tissue morphogenesis in the Drosophila pupal wing
Piscitello-Gomez, R.; Gruber, F.; Krishna, A.; Duclut, C.; Modes, C. D.; Popovic, M.; Julicher, F.; Dye, N. A.; Eaton, S.
10.1101/2022.12.09.519799 — developmental biology — Posted on 2022-12-10
2806 Disrupted RNA editing in beta cells mimics early stage type 1 diabetes
Knebel, E.; Peleg, S.; Dai, C.; Cohen-Fultheim, R.; Glaser, B.; Levanon, E.; Powers, A.; Klochendler, A.; Dor, Y.
10.1101/2022.12.08.519618 — cell biology — Posted on 2022-12-10
2807 Disruption of the nuclear localization signal in RBM20 is causative in dilated cardiomyopathy
Zhang, Y.; Gregorich, Z. R.; Wang, Y.; Braz, C. U.; Zhang, J.; Liu, Y.; Liu, P.; Aori, N.; Hacker, T. A.; Granzier, H.; Guo, W.
10.1101/2022.12.08.519616 — cell biology — Posted on 2022-12-10
2808 Multi-omics analysis of paracetamol exposure identifies dysregulated genes involved in neurotoxicity and neuronal differentiation of human embryonic stem cells
Spildrejorde, M.; Samara, A.; Sharma, A.; Leithaug, M.; Falck, M.; Modafferi, S.; Sundaram, A.; Acharya, G.; Nordeng, H.; Eskeland, R.; Gervin, K.; Lyle, R.
10.1101/2022.12.08.519620 — cell biology — Posted on 2022-12-10
2809 Mre11 liberates cGAS from nucleosome sequestration during tumorigenesis
Cho, M.-G.; Kumar, R. J.; Lin, C.-C.; Boyer, J. A.; Shahir, J. A.; Fagan-Solis, K.; Simpson, D. A.; Fan, C.; Foster, C. E.; Goddard, A. M.; Wang, Q.; Wang, Y.; Ho, A. Y.; Liu, P.; perou, c. J.; Zhang, Q.; McGinty, R. K.; Purvis, J. E.; Gupta, G. P.
10.1101/2022.12.09.519750 — cell biology — Posted on 2022-12-10
2810 DNA damage-induced lncRNA MEG9 impacts angiogenesis
Fraile-Bethencourt, E.; Khou, S.; Wilson, R.; Baris, A.; Ruhl, R.; Espinosa-Diez, C.; Anand, S.
10.1101/2022.12.07.519382 — cell biology — Posted on 2022-12-10
2811 Species-specific LUBAC-mediated M1 ubiquitination counteracts necroptosis by segregating the cellular distribution and fate of activated MLKL
Weinelt, N.; Waechtershaeuser, K. N.; Smith, S.; Andrieux, G.; Das, T.; Jeiler, B.; Roedig, J.; Feist, L.; Rotter, B.; Boerries, M.; Pampaloni, F.; van Wijk, S. J. L.
10.1101/2022.12.08.519265 — cell biology — Posted on 2022-12-10
2812 Micronutrient Optimization Using Design of Experiments Approach in Tissue Engineered Articular Cartilage for Production of Type II Collagen
Cruz, M. A.; Gonzalez, Y.; Toro, J. V.; Karimzadeh, M.; Rubbo, A.; Morris, L.; Medam, R.; Splawn, T.; Archer, M.; Fernandes, R. J.; Dennis, J. E.; Kean, T. J.
10.1101/2022.12.07.519522 — cell biology — Posted on 2022-12-10
2813 Lipid Biosynthesis Perturbation Impairs Endoplasmic Reticulum-Associated Degradation
Turk, S. M.; Indovina, C. J.; Overton, D. L.; Runnebohm, A. M.; Orchard, C. J.; Doss, E. M.; Richards, K. A.; Irelan, C. B.; Daraghmi, M. M.; Bailey, C. G.; Miller, J. M.; Niekamp, J. M.; Gosser, S. K.; Tragesser-Tina, M. E.; Claypool, K. P.; Engle, S. M.; Buchanan, B. W.; Woodruff, K. A.; Olesen, J. B.; Smaldino, P. J.; Rubenstein, E. M.
10.1101/2022.12.09.519544 — cell biology — Posted on 2022-12-10
2814 FiNuTyper: an automated deep learning-based platform for simultaneous fiber and nucleus type analysis in human skeletal muscle
Lundquist, A.; Lazar, E.; Han, N. S.; Emanuelsson, E.; Reitzner, S. M.; Chapman, M. A.; Alkass, K.; Druid, H.; Petri, S.; Sundberg, C. J.; Bergmann, O.
10.1101/2022.12.08.519285 — cell biology — Posted on 2022-12-10
2815 A high-quality reference genome for the fission yeast Schizosaccharomyces osmophilus
Jia, G.-S.; Zhang, W.-C.; Liang, Y.; Liu, X.-H.; Rhind, N.; Pidoux, A.; Brysch-Herzberg, M.; Du, L.-L.
10.1101/2022.12.06.519325 — genomics — Posted on 2022-12-10
2820 Reward expectations direct learning and drive operant matching in Drosophila
Rajagopalan, A.; Darshan, R.; Hibbard, K. L.; Fitzgerald, J. E.; Turner, G. C.
10.1101/2022.05.24.493252 — neuroscience — Posted on 2022-12-10
2821 Cerebral perfusion in post-stroke aphasia and its relation to residual language abilities
Ivanova, M. V.; Pappas, I.; Inglis, B.; Pracar, A.; Herron, T. J.; Baldo, J. V.; Kayser, A. S.; D'Esposito, M.; Dronkers, N. F.
10.1101/2022.07.01.498516 — neuroscience — Posted on 2022-12-10
2822 Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor
Ciampa, E. J.; Flahardy, P.; Srinivasan, H.; Jacobs, C.; Tsai, L.; Karumanchi, S. A.; Parikh, S. M.
10.1101/2022.03.14.483784 — physiology — Posted on 2022-12-10
2825 Toeholder: a software for automated design and in silico validation of toehold riboswitches
Cisneros Caballero, A. F.; Rouleau, F. D.; Bautista, C.; Lemieux, P.; Dumont-Leblond, N.
10.1101/2021.11.09.467922 — bioinformatics — Posted on 2022-12-10
2829 An ESCRT-dependent pathway of Nuclear and Cytoplasmic Spatial PQC is coordinated at Nuclear Vacuolar Junctions
Sontag, E. M.; Morales-Polanco, F.; Chen, J.-H.; McDermott, G.; Dolan, P. T.; Gestaut, D. R.; LeGros, M. A.; Larabell, C.; Frydman, J.
10.1101/2022.12.01.518779 — biochemistry — Posted on 2022-12-10
2830 Enhancer grammar of liver cell types and hepatocyte zonation states
Bravo Gonzalez-Blas, C.; Matetovici, I.; Hillen, H.; Taskiran, I. I.; Vandepoel, R.; Christiaens, V.; Sansores-Garcia, L.; Verboven, E.; Hulselmans, G.; Poovathingal, S.; Demeulemeester, J.; Psatha, N.; Mauduit, D.; Halder, G.; Aerts, S.
10.1101/2022.12.08.519575 — genomics — Posted on 2022-12-09
2832 Characterisation of neonatal Staphylococcus capitis NRCS-A isolates compared with non NRCS-A Staphylococcus capitis from neonates and adults.
Felgate, H. M.; Sethi, D.; Faust, K.; Kiy, C.; Härtel, C.; Rupp, J.; Clifford, R.; Dean, R.; Tremlett, C.; Wain, J.; Langridge, G.; Clarke, P.; Page, A. J.; Webber, M. A.
10.1101/2022.12.02.518718 — genomics — Posted on 2022-12-10
2833 OTTERS: A powerful TWAS framework leveraging summary-level reference data
Dai, Q.; Zhou, G.; Zhao, H.; Vosa, U.; Franke, L.; Battle, A.; Teumer, A.; Lehtimaki, T.; Raitakari, O.; Esko, T.; eQTLGen Consortium, ; Epstein, M. P.; Yang, J.
10.1101/2022.03.30.486451 — genetics — Posted on 2022-12-10
2835 The contrasted impacts of grasshoppers on soil microbial activities in function of primary production and herbivore diet
Ibanez, S.; Foulquier, A.; Brun, C.; Colace, M.-P.; Piton, G.; Bernard, L.; Gallet, C.; Clément, J.-C.
10.1101/2022.07.04.497718 — ecology — Posted on 2022-12-09
2836 Convergent remodeling of the gut microbiome is associated with host energetic condition over long-distance migration
Trevelline, B. K.; Sprockett, D.; DeLuca, W. V.; Andreadis, C. R.; Moeller, A. H.; Tonra, C. M.
10.1101/2022.11.30.518533 — ecology — Posted on 2022-12-10
2837 Oct1 recruits the histone lysine demethylase Utx to promote lineage specification
Perovanovic, J.; Wu, Y.; Abewe, H.; Shen, Z.; Hughes, E. P.; Gertz, J.; Chandrasekharan, M. B.; Tantin, D.
10.1101/2020.12.01.406488 — developmental biology — Posted on 2022-12-09
2841 Functional and microstructural plasticity following social and interoceptive mental training.
Valk, S. L.; Kanske, P.; Park, B.-y.; Hong, S.-J.; Boeckler, A.; Trautwein, F.-M.; Bernhardt, B. C.; Singer, T.
10.1101/2020.11.11.377895 — neuroscience — Posted on 2022-12-09
2843 Inhibitory interneurons show early dysfunction in a SOD1 mouse model of amyotrophic lateral sclerosis
Cavarsan, C. F.; Steele, P. R.; Genry, L. T.; Reedich, E. J.; McCane, L. M.; LaPre, K. J.; Puritz, A. C.; Manuel, M.; Katenka, N.; Quinlan, K. A.
10.1101/2020.10.21.348359 — neuroscience — Posted on 2022-12-10
2844 Arc ubiquitination regulates endoplasmic reticulum-mediated Ca2+ release and CaMKII signaling
Ghane, M. A.; Allen, Z. D.; Miller, C. L.; Dong, B.; Fang, N.; Yang, J. J.; Mabb, A. M.
10.1101/2022.09.02.506383 — neuroscience — Posted on 2022-12-10
2845 Climate of origin influences how a herbivorous mite responds to drought-stressed host plants
Migeon, A.; Auger, P.; Fossati-Gaschigard, O.; Hufbauer, R. A.; Miranda, M.; Zriki, G.; Navajas, M.
10.1101/2021.10.21.465244 — zoology — Posted on 2022-12-09
2846 Exploring cognitive, behavioural and autism trait network topology in very preterm and term-born children
Leoni, M.; Vanes, L.; Hadaya, L.; Kanel, D.; Dazzan, P.; Simonoff, E.; Counsell, S.; Happe, F.; Edwards, A. D.; Nosarti, C.
10.1101/2022.12.09.519321 — developmental biology — Posted on 2022-12-09
2847 p38γ and p38δ modulate innate immune response by regulating MEF2D activation
Cuenda, A.; Escos, A.; Diaz-Mora, E.; Fajardo, P.; Gonzalez-Romero, D.; Risco, A.; Martin-Gomez, J.; Bonneil, E.; Sonenberg, N.; Jafarnejad, S. M.; Pattison, M.; Sanz-Ezquerro, J. J.; Ley, S. C.
10.1101/2022.12.09.519777 — molecular biology — Posted on 2022-12-09
2848 Conformational restriction shapes inhibition of a multidrug efflux adaptor protein
Russell Lewis, B.; Uddin, M. R.; Moniruzzaman, M.; Kuo, K. M.; Higgins, A. J.; Shah, L. M. N.; Sobott, F.; Parks, J. M.; Hammerschmid, D.; Gumbart, J. C.; Zgurskaya, H. I.; Reading, E.
10.1101/2022.12.09.519754 — biochemistry — Posted on 2022-12-09
2850 Tryptophan-like side chain holding aptamers inhibit respiratory syncytial virus infection of lung epithelial cells
Percze, K.; Tolnai, Z. J.; Eleveld, M.; Ou, L.; Du, H.; Olia, A. S.; Kwong, P. D.; de Jonge, M. I.; Meszaros, T.
10.1101/2022.12.09.519757 — molecular biology — Posted on 2022-12-09
2854 Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus
Rosinski, J. R.; Raasch, L. E.; Barros Tiburcio, P.; Breitbach, M. E.; Shepherd, P. M.; Yamamoto, K.; Razo, E.; Krabbe, N. P.; Bliss, M. I.; Richardson, A. D.; Einwalter, M. A.; Weiler, A. M.; Sneed, E. L.; Fuchs, K. B.; Zeng, X.; Noguchi, K. K.; Morgan, T. K.; Alberts, A. J.; Antony, K. M.; Spanton, R. V.; Kabakov, S.; Ausderau, K. K.; Bohm, E. K.; Pritchard, J. C.; Ver Hoeve, J.; Spanton, R. V.; Kim, C.; Nork, T. M.; Katz, A. W.; Rasmussen, C. A.; Hartman, A.; Mejia, A.; Basu, P.; Simmons, H. A.; Eickhoff, J. C.; Friedrich, T. C.; Aliota, M. T.; Mohr, E. L.; Dudley, D. M.; O'Connor, D. H.; N
10.1101/2022.12.09.519791 — microbiology — Posted on 2022-12-09
2855 New Aequorea fluorescent proteins for cell-free bioengineering
Deich, C.; Gaut, N. J.; Sato, W.; Engelhart, A. E.; Adamala, K. P.
10.1101/2022.12.08.519681 — synthetic biology — Posted on 2022-12-09
2856 Structural basis for translation inhibition 1 by the glycosylated antimicrobial peptide Drosocin from Drosophila melanogaster
Koller, T. O.; Morici, M.; Berger, M.; Safdari, H.; Lele, D. S.; Beckert, B.; Kaur, K. J.; Wilson, D. N.
10.1101/2022.12.08.519698 — biochemistry — Posted on 2022-12-09
2857 FKBP35 secures ribosome homeostasis in Plasmodium falciparum
Thommen, B. T.; Dziekan, J. M.; Achcar, F.; Tjia, S.; Passecker, A.; Buczak, K.; Gumpp, C.; Schmidt, A.; Rottmann, M.; Gruering, C.; Marti, M.; Bozdech, Z.; Brancucci, N. M. B.
10.1101/2022.12.09.519720 — molecular biology — Posted on 2022-12-09
2860 Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the hepatitis C virus
Pham, M.-T.; Lee, J.-Y.; Ritter, C.; Thielemann, R.; Haselmann, U.; Funaya, C.; Laketa, V.; Rohr, K.; Bartenschlager, R.
10.1101/2022.12.08.519703 — microbiology — Posted on 2022-12-09
2863 Genetic Variants of Phospholipase C-γ 2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimers Disease
Tsai, A. P.; Dong, C.; Lin, P. B.-C.; Oblak, A. L.; Viana Di Prisco, G.; Wang, N.; Hajicek, N.; Carr, A. J.; Lendy, E. K.; Hahn, O.; Atkins, M.; Foltz, A. G.; Patel, J.; Xu, G.; Moutinho, M.; Sondek, J.; Zhang, Q.; Mesecar, A. D.; Liu, Y.; Atwood, B. K.; Wyss-Coray, T.; Nho, K. T.; Bissel, S. J.; Lamb, B. T.; Landreth, G. E.
10.1101/2022.12.08.519685 — neuroscience — Posted on 2022-12-09
2864 SARM1 detection in oligodendrocytes but not Schwann cells though sarm1/Sarm1 deletion does not perturb CNS nor PNS myelination in zebrafish and mice.
Fazal, S. V.; Mutschler, C.; Chen, C.; Turmaine, M.; Chen, C.-Y.; Hsueh, Y.-P.; Loreto, A.; Casillas-Bajo, A.; Cabedo, H.; Franklin, R. J.; Barker, R. A.; Monk, K.; Steventon, B.; Coleman, M.; Gomez-Sanchez, J. A.; Arthur-Farraj, P.
10.1101/2022.12.08.519209 — neuroscience — Posted on 2022-12-09
2865 Color and gloss constancy under diverse lighting environments
Morimoto, T.; Akbarinia, A.; Storrs, K. R.; Cheeseman, J. R.; Smithson, H. E.; Gegenfurtner, K. R.; Fleming, R. W.
10.1101/2022.12.09.519756 — neuroscience — Posted on 2022-12-09
2866 5-HT1A and 5-HT2B receptor interaction and co-clustering regulates serotonergic neuron excitability
Benhadda, A.; Delhaye, C.; Moutkine, I.; Marques, X.; Russeau, M.; Le Magueresse, C.; Roumier, A.; Levi, S.; Maroteaux, L.
10.1101/2022.12.09.519723 — neuroscience — Posted on 2022-12-09
2868 Parental effects in a filamentous fungus: phenotype, fitness, and mechanism
Villalba de la Pena, M.; Summanen, P. A. M.; Moghadam, N. N.; Kronholm, I.
10.1101/2022.12.09.519717 — microbiology — Posted on 2022-12-09
2870 Neisseria gonorrhoeae co-opts C4b-binding protein to enhance complement-independent survival from neutrophils
Werner, L. M.; Alcott, A.; Mohlin, F.; Ray, J. C.; Belcher Dufrisne, M.; Smirnov, A.; Columbus, L.; Blom, A. M.; Criss, A. K.
10.1101/2022.12.08.519701 — microbiology — Posted on 2022-12-09
2875 Golgi Fragmentation - One of the Earliest Organelle Phenotypes in Alzheimer's Disease Neurons
Haukedal, H.; Corsi, G. I.; Gadekar, V. P.; Doncheva, N. T.; Kedia, S.; de Haan, N.; Chandrasekaran, A.; Jensen, P.; Schionning, P.; Vallin, S.; Marlet, F. R.; Poon, A.; Pires, C.; Agha, F. K.; Wandall, H. H.; Cirera, S.; Simonsen, A. H.; Nielsen, T. T.; Nielsen, J. E.; Hyttel, P.; Muddashetty, R.; Aldana, B. I.; Gorodkin, J.; Nair, D.; Meyer, M.; Larsen, M. R.; Freude, K.
10.1101/2022.12.09.519571 — neuroscience — Posted on 2022-12-09
2878 metaDMG - A Fast and Accurate Ancient DNA Damage Toolkit for Metagenomic Data
Michelsen, C.; Pedersen, M. W.; Fernandez-Guerra, A.; Zhao, L.; Petersen, T. C.; Korneliussen, T. S.
10.1101/2022.12.06.519264 — bioinformatics — Posted on 2022-12-09
2879 Heating tolerance of ectotherms is explained by temperature's non-linear influence on biological rates
Kong, J. D.; Arnoldi, J.-F.; Jackson, A. L.; Bates, A. E.; Morley, S. A.; Smith, J. A.; Payne, N. L.
10.1101/2022.12.06.519315 — ecology — Posted on 2022-12-09
2880 Transboundary hotspots associated with SARS-like coronavirus spillover risk: implications for mitigation
Muylaert, R. L.; Wilkinson, D. A.; Kingston, T.; D`Odorico, P.; Rulli, M. C.; Galli, N.; John, R. S.; Alviola, P.; Hayman, D. T. S.
10.1101/2022.12.08.518776 — ecology — Posted on 2022-12-09
2881 Biochemistry-informed design selects potent siRNAs against SARS-CoV-2
Houbron, E.; Mockly, S.; Rafasse, S.; Gros, N.; Muriaux, D.; Seitz, H.
10.1101/2022.12.08.519651 — molecular biology — Posted on 2022-12-09
2882 Global loss of cellular m6A RNA methylation following infection with different SARS-CoV-2 variants
Vaid, R.; Mendez, A.; Thombare, K.; Burgos-Panadero, R.; Robinot, R.; Fonseca, B. F.; Gandasi, N. R.; Ringlander, J.; Baig, M. H.; Dong, J.-J.; Cho, J. Y.; Reinius, B.; Chakrabarti, L. A.; Nystrom, K.; Mondal, T.
10.1101/2022.12.08.519593 — molecular biology — Posted on 2022-12-09
2883 TMPRSS2 is essential for SARS-CoV-2 Beta and Omicron infection
Metzdorf, K.; Jacobsen, H.; Greweling-Pils, M. C.; Hoffmann, M.; Lueddecke, T.; Miller, F.; Melcher, L.; Kempf, A. M.; Nehlmeier, I.; Bruder, D.; Widera, M.; Ciesek, S.; Poehlmann, S.; Cicin-Sain, L.
10.1101/2022.12.09.519765 — immunology — Posted on 2022-12-09
2884 Structural pre-training improves physical accuracy of antibody structure prediction using deep learning.
Konczak, J.; Janusz, B.; Mlokosiewicz, J.; Satlawa, T.; Wrobel, S.; Dudzic, P.; Krawczyk, K.
10.1101/2022.12.06.519288 — bioinformatics — Posted on 2022-12-09
2886 ModelCIF: An extension of PDBx/mmCIF data representation for computed structure models
Vallat, B.; Tauriello, G.; Bienert, S.; Haas, J.; Webb, B. M.; Zidek, A.; Zheng, W.; Peisach, E.; Piehl, D. W.; Anishchanka, I.; Sillitoe, I.; Tolchard, J.; Varadi, M.; Baker, D.; Orengo, C.; Zhang, Y.; Hoch, J.; Kurisu, G.; Patwardhan, A.; Velankar, S.; Burley, S. K.; Sali, A.; Schwede, T.; Berman, H. M.; Westbrook, J. D.
10.1101/2022.12.06.518550 — bioinformatics — Posted on 2022-12-09
2888 A high-quality reference genome for the fission yeast Schizosaccharomyces osmophilus
Jia, G.-S.; Zhang, W.-C.; Liang, Y.; Liu, X.-H.; Rhind, N.; Pidoux, A.; Brysch-Herzberg, M.; Du, L.-L.
10.1101/2022.12.06.519325 — genomics — Posted on 2022-12-09
2890 DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age
Urbanus, J.; Cosgrove, J.; Beltman, J.; Elhanati, Y.; De Andrade Moral, R.; Conrad, C.; Van Heijst, J.; Tubeuf, E.; Velds, A.; Kok, L.; Merle, C.; Magnusson, J. P.; Frisen, J.; Fre, S.; Walczak, A.; Mora, T.; Jacobs, H.; Shumacher, T.; Perie, L.
10.1101/2022.12.06.519273 — immunology — Posted on 2022-12-09
2893 A liver-specific mitochondrial carrier that controls gluconeogenesis and energy expenditure
Yook, J.-S.; Taxin, Z. H.; Yuan, B.; Oikawa, S.; Auger, C.; Mutlu, B.; Puigserver, P.; Hui, S.; Kajimura, S.
10.1101/2022.12.06.519308 — physiology — Posted on 2022-12-09
2895 Large-scale changes of molecular network states explain complex traits
Beyer, A.; Weith, M.; Grossbach, J.; Clement-Ziza, M.; Gillet, L.; Rodriguez-Lopez, M.; Picotti, P.; Bähler, J.; Rudolf, A.; Marguerat, S.; Workman, C. T.
10.1101/2022.12.05.519111 — systems biology — Posted on 2022-12-09
2897 Learning the differences: a transfer-learning approach to predict antigen immunogenicity and T-cell receptor specificity
Bravi, B.; Di Gioacchino, A.; Fernandez-de-Cossio-Diaz, J.; Walczak, A. M.; Mora, T.; Cocco, S.; Monasson, R.
10.1101/2022.12.06.519259 — bioinformatics — Posted on 2022-12-09
2898 Discovering Haematoma-Stimulated Circuits for Secondary Brain Injury after Intraventricular Haemorrhage by Spatial Transcriptome Analysis
Zhang, L.; Badai, J.; Wang, G.; Ru, X.; Song, W.; You, Y.; He, J.; Huang, S.; Feng, H.; Chen, R.; Zhao, Y.; Chen, Y.
10.1101/2022.12.06.519018 — bioinformatics — Posted on 2022-12-09
2900 Multiscale Mechanical Characterization and Computational Modeling of Fibrin Gels
Jimenez, J. M.; Tuttle, T. G.; Guo, Y.; Miles, D. T.; Tepole, A. B.; Calve, S.
10.1101/2022.12.06.519227 — bioengineering — Posted on 2022-12-09
2902 No supergene despite social polymorphism in the big-headed ant Pheidole pallidula
Favreau, E.; Lebas, C.; Stolle, E.; Priyam, A.; Pracana, R.; Aron, S.; Wurm, Y.
10.1101/2022.12.06.519286 — evolutionary biology — Posted on 2022-12-09
2904 PADAPT 1.0 - the Pannonian Database of Plant Traits
Sonkoly, J.; Toth, E.; Balogh, N.; Balogh, L.; Bartha, D.; Bata, K.; Batori, Z.; Bekefi, N.; Botta-Dukat, Z.; Bölöni, J.; Csecserits, A.; Csiky, J.; Csontos, P.; Dancza, I.; Balazs, D.; Dobolyi, Z. K.; E-Vojtko, A.; Gyulai, F.; Habenczyus, A. A.; Henn, T.; Horvath, F.; Höhn, M.; Jakab, G.; Kelemen, A.; Kiraly, G.; Kis, S.; Kovacsics-Vari, G.; Kun, A.; Lehoczky, E.; Lengyel, A.; Lhotsky, B.; Löki, V.; Lukacs, B. A.; Matus, G.; McIntosh-Buday, A.; Mesterhazy, A.; Miglecz, T.; Molnar, A.; Molnar, Z.; Morschhauser, T.; Papp, L.; Posa, P.; Redei, T.; Schmidt, D.; Szmorad, F.; Takacs, A.; Tamas,
10.1101/2022.12.05.519136 — ecology — Posted on 2022-12-09
2906 Coupled carbon and nitrogen cycling regulates the cnidarian-algal symbiosis
Radecker, N.; Escrig, S.; Spangenberg, J. E.; Voolstra, C. R.; Meibom, A.
10.1101/2022.12.06.519281 — ecology — Posted on 2022-12-09
2909 Transposable elements contribute to the establishment of the glycine shuttle in Brassicaceae species
Triesch, S.; Denton, A. K.; Buchmann, J. P.; Reichel-Deland, V.; Schlueter, U.; Weber, A. P. M.
10.1101/2022.12.06.519256 — plant biology — Posted on 2022-12-09
2912 Heterotrophic bacteria drive sulfide oxidation in coastal sediments
Liu, H.; Xun, L.; Qin, Q.-L.; Xia, Y.; Wang, Q.; Lu, C.; Yang, Y.; Cao, Q.
10.1101/2022.12.07.519552 — microbiology — Posted on 2022-12-09
2914 Multi-Omics Regulatory Network Inference in the Presence of Missing Data
Henao, J. D.; Lauber, M.; Azevedo, M.; Grekova, A.; Theis, F. J.; List, M.; Ogris, C.; Schubert, B.
10.1101/2022.04.14.488153 — systems biology — Posted on 2022-12-09
2915 Skeletal muscle hypertrophy rewires glucose metabolism in mice: an experimental investigation and systematic review
Baumert, P.; Mantyselka, S.; Schoenfelder, M.; Heiber, M.; Swaminathan, A.; Minderis, P.; Dirmontas, M.; Kleigrewe, K.; Meng, C.; Gigl, M.; Venckunas, T.; Degens, H.; Ratkevicius, A.; Hulmi, J.; Wackerhage, H.
10.1101/2022.12.08.519580 — molecular biology — Posted on 2022-12-09
2917 Hoverfly (Eristalis tenax) pursuit of artificial targets
Thyselius, M.; Ogawa, Y.; Leibbrandt, R.; Wardill, T. J.; Gonzalez-Bellido, P. T.; Nordstrom, K.
10.1101/2022.07.27.501787 — animal behavior and cognition — Posted on 2022-12-09
2919 Regulatory heterogeneity of Vegf- and Wnt7-dependent angiogenesis drives phenotypic diversity of brain vasculature
Parab, S.; Card, O. A.; Chen, Q.; Buck, L. D.; Quick, R. E.; Horrigan, W. F.; Levkowitz, G.; Vanhollebeke, B.; Matsuoka, R. L.
10.1101/2022.12.08.519692 — developmental biology — Posted on 2022-12-09
2923 Functional characterization of cytochrome P450s associated with pyrethroid resistance in the olive fruit fly Bactrocera oleae
Kampouraki, A.; Tsakireli, D.; Koidou, V.; Stavrakaki, M.; Kaili, S.; Livadaras, I.; Grigoraki, L.; Ioannidis, P.; Roditakis, E.; Vontas, J.
10.1101/2022.12.07.519177 — molecular biology — Posted on 2022-12-08
2924 A unified classification system for HIV-1 5' long terminal repeats
Guo, X.; Yu, D.; Liu, M.; Li, H. P.; Chen, M.; Wang, X.; Zhai, X.; Zhang, B.; Wang, Y.; Yang, C.; Wang, C.; Liu, Y. J.; Han, J.; Wang, X.; Li, T.; Li, J.; Jia, L.; Li, L.
10.1101/2022.12.07.519241 — microbiology — Posted on 2022-12-08
2925 Microbiome, resistome and mobilome of chlorine-free drinking water treatment systems
Calderon-Franco, D.; Corbera-Rubio, F.; Cuesta-Sanz, M.; Pieterse, B.; de Ridder, D.; van Loosdrecht, M.; van Halem, D.; Laureni, M.; Weissbrodt, D. G.
10.1101/2022.12.08.519565 — microbiology — Posted on 2022-12-08
2926 A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma stimulated human cells
Lockyer, E.; Torelli, F.; Butterworth, S.; Song, O.-R.; Howell, S.; Weston, A.; East, P.; Treeck, M.
10.1101/2022.12.08.519568 — microbiology — Posted on 2022-12-08
2927 Cell type-specific disruption of cortico-striatal circuitry drive repetitive patterns of behaviour in fragile X syndrome model mice
Longo, F.; Aryal, S.; Anastasiades, P.; Maltese, M.; Baimel, C.; Albanese, F.; Tabor, J.; Zhu, J.; Oliveira, M. M.; Gastaldo, D.; Bagni, C.; Santini, E.; Tritsch, N. X.; Carter, A. G.; Klann, E.
10.1101/2022.12.08.519509 — neuroscience — Posted on 2022-12-08
2930 ChILL & DisCO to discover competitive, connective and allosteric Nanobodies that modulate the SOS1-RAS protein-protein interactions and tune the nucleotide exchange rate
Fischer, B.; Uchanski, T.; Sheryazdanova, A.; Gonzalez, S.; Volkov, A.; Brosens, E.; Zogg, T.; Kalichuk, V.; Ballet, S.; Versees, W.; Sablina, A.; Pardon, E.; Wohlkonig, A.; Steyaert, J.
10.1101/2022.12.06.519258 — bioengineering — Posted on 2022-12-08
2931 The Aphelenchoides genomes reveal substantial horizontal gene transfers in the last common ancestor of free-living and major plant parasitic nematodes
Lai, C.-K.; Lee, Y.; Ke, H.-M.; Lu, M. R.; Liu, W.-A.; Lee, H.-H.; Liu, Y.-C.; Yoshiga, T.; Kikuchi, T.; Chen, P. J.; Tsai, I. J.
10.1101/2022.09.13.507733 — genomics — Posted on 2022-12-08
2932 First gene-edited calf with reduced susceptibility to a major viral pathogen
Workman, A. M.; Heaton, M. P.; Vander Ley, B. L.; Webster, D. A.; Sherry, L.; Larson, S.; Kalbfleisch, T.; Harhay, G. P.; Jobman, E. E.; Carlson, D. F.; Sonstegard, T. S.
10.1101/2022.12.08.519336 — genomics — Posted on 2022-12-08
2934 Dynamics and composition of small heat shock protein condensates and aggregates
Joosten, J.; van Sluijs, B.; Vree Egberts, W.; Emmaneel, M.; Jansen, P. W. T. C.; Vermeulen, M.; Boelens, W.; Bonger, K. M.; Spruijt, E.
10.1101/2022.12.08.519563 — molecular biology — Posted on 2022-12-08
2937 STOmics-GenX: CRISPR based approach to improve cell identity specific gene detection from spatially resolved transcriptomics
Currenti, J.; Qiao, L.; Pai, R.; Gupta, S.; Khyriem, C.; Wise, K.; Sun, X.; Armstrong, J.; Crane, J.; Pathak, S.; Yang, B.; George, J.; Plummer, J.; Martelotto, L.; Sharma, A.
10.1101/2022.12.08.519589 — molecular biology — Posted on 2022-12-08
2939 Repeated evolution of bedaquiline resistance in Mycobacterium tuberculosis is driven by truncation of mmpR5
Roberts, L. W.; Malone, K. M.; Hunt, M.; Joseph, L.; Wintringer, P.; Knaggs, J.; Crook, D.; Farhat, M. R.; Iqbal, Z.; Omar, S. V.
10.1101/2022.12.08.519610 — microbiology — Posted on 2022-12-08
2940 Deep divergence and genomic diversification of gut symbionts of neotropical stingless bees
Sarton-Loheac, G.; Nunes da Silva, C. G.; Mazel, F.; Baud, G.; de Bakker, V.; Das, S.; El Chazli, Y.; Ellegaard, K. M.; Garcia-Garcera, M.; Glover, N. M.; Liberti, J. M.; Nacif Marcal, L.; Prasad, A.; Somerville, V.; SAGE class 2019-2020 and 2020-2021, ; Bonilla Rosso, G.; Engel, P.
10.1101/2022.12.08.519137 — microbiology — Posted on 2022-12-08
2942 At Which Low Amplitude Modulated Frequency Do Infants Best Entrain? A Frequency Tagging Study
Ives, J.; Labendzki, P.; Perapoch Amado, M.; Greenwood, E.; Viswanathan, N.; Northrop, T.; Wass, S. V.
10.1101/2022.12.08.519576 — neuroscience — Posted on 2022-12-08
2943 BCI learning phenomena can be explained by gradient-based optimization
Humphreys, P. C.; Daie, K.; Svoboda, K.; Botvinick, M.; Lillicrap, T. P.
10.1101/2022.12.08.519453 — neuroscience — Posted on 2022-12-08
2949 Lysine deserts prevent adventitious ubiquitylation of ubiquitin-proteasome components
Kampmeyer, C.; Gronbaek-Thygesen, M.; Oelerich, N.; Tatham, M. H.; Cagiada, M.; Lindorff-Larsen, K.; Boomsma, W.; Hofmann, K.; Hartmann-Petersen, R.
10.1101/2022.12.08.519562 — biochemistry — Posted on 2022-12-08
2950 Metabolomic Profiling to Identify Early Urinary Biomarkers and Metabolic Pathway Alterations in Autosomal Dominant Polycystic Kidney Disease
Hahn, A. K.; Houske, E. A.; Glimm, M. G.; Bergstrom, A. R.; Slipher, S. K.; Welhaven, H. D.; Greenwood, M. C.; Linse, G. M.; June, R. K.; Yu, A. S. L.; Wallace, D. P.
10.1101/2022.12.08.519365 — biochemistry — Posted on 2022-12-08
2951 Prospecting for zoonotic pathogens using targeted DNA enrichment
Enabulele, E. E.; Le Clec'h, W.; Roberts, E. K.; Thompson, C. W.; McDonough, M. M.; Ferguson, A. W.; Bradley, R. D.; Anderson, T. J. C.; Platt, R. N.
10.1101/2022.12.06.519193 — genomics — Posted on 2022-12-08
2954 Optimisation of immunocytochemistry methodology for the detection of endogenous eIF2B localised foci
de Oliveira, M. I. R.; Hanson, F. M.; Hodgson, R. E.; Cross, A. K.; Campbell, S. G.; Allen, K. E.
10.1101/2022.12.06.519266 — cell biology — Posted on 2022-12-08
2955 Skeletal muscle hypertrophy rewires glucose metabolism in mice: an experimental investigation and systematic review
Baumert, P.; Mantyselka, S.; Schoenfelder, M.; Heiber, M.; Swaminathan, A.; Minderis, P.; Dirmontas, M.; Kleigrewe, K.; Meng, C.; Gigl, M.; Venckunas, T.; Degens, H.; Ratkevicius, A.; Hulmi, J.; Wackerhage, H.
10.1101/2022.12.08.519580 — molecular biology — Posted on 2022-12-08
2956 Small-spored Alternaria spp. (section Alternaria) are common on wild tomato species
Schmey, T.; Small, C.; Munoz Hoyos, L.; Ali, T.; Gamboa, S.; Mamani, B.; Sepulveda, G.; Thines, M.; Stam, R.
10.1101/2022.12.08.519636 — microbiology — Posted on 2022-12-08
2959 Metatranscriptome of infected root canals in teeth with apical periodontitis
Pinheiro, E. T.; Russo, G.; Candeiro, G. T. M.; Vilela, B. G.; Gomes, B. P. F. A.; Attin, T.; Karygianni, L.; Thurnheer, T.
10.1101/2022.12.08.519614 — microbiology — Posted on 2022-12-08
2961 Global profiling of human blood ILC subtypes reveals that NK cells produce homeostatic cytokine amphiregulin and sheds light on HIV-1 pathogenesis
Wang, Y.; Lifshitz, L.; Silverstein, N.; Mintzer, E.; Luk, K.; StLouis, P.; Brehm, M.; Wolfe, S.; Deeks, S.; Luban, J.
10.1101/2021.04.20.440368 — immunology — Posted on 2022-12-08
2964 Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer's disease
Modeste, E. S.; Ping, L.; Watson, C. M.; Duong, D. M.; Dammer, E. B.; Johnson, E. C. B.; Roberts, B. R.; Lah, J. J.; Levey, A. I.; Seyfried, N. T.
10.1101/2022.12.07.519393 — neuroscience — Posted on 2022-12-08
2967 PDX3 is important for carbon/nitrogen balance in Arabidopsis associated with distinct environmental conditions
Steensma, P.; Eisenhut, M.; Colinas, M.; Rosado-Souza, L.; Fernie, A. R.; Weber, A. P. M.; Fitzpatrick, T. B.
10.1101/2022.12.06.519276 — plant biology — Posted on 2022-12-08
2971 First Biodegradable Bioactive Glass-based Humidity Sensor
Gharbi, A.; Kallel, A. Y.; Kanoun, O.; Cheikhrouhou-Koubaa, W.; H. Contag, C.; Antoniac, I.; Derbel, N.; Ashammakhi, N.
10.1101/2022.12.06.519262 — bioengineering — Posted on 2022-12-08
2974 NAPS: Integrating pose estimation and tag-based tracking
Wolf, S. W.; Ruttenberg, D. M.; Knapp, D. Y.; Webb, A. E.; Traniello, I. M.; McKenzie-Smith, G. C.; Leheny, S. A.; Shaevitz, J. W.; Kocher, S. D.
10.1101/2022.12.07.518416 — animal behavior and cognition — Posted on 2022-12-08
2976 Fungal traits help to understand the decomposition of simple and complex plant litter
Leifheit, E. F.; Camenzind, T.; Lehmann, A.; Andrade-Linares, D. R.; Fussan, M.; Westhusen, S.; Wineberger, T. M.; Rillig, M. C.
10.1101/2022.12.06.519268 — ecology — Posted on 2022-12-08
2979 IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling
Bachus, H.; McLaughlin, E.; Lewis, C.; Papillion, A. M.; Benveniste, E. N.; Hill, D. D.; Rosenberg, A. F.; Ballesteros-Tato, A.; Leon, B.
10.1101/2022.12.05.519197 — immunology — Posted on 2022-12-08
2980 New insight into the Germline Genes and CDR3 Repertoire of the TCRβ chain in Chiroptera
Zhou, H.; Yao, X. S.; Li, J.; Ma, Q. Q.; Liu, L. Y.; Zhou, D. W.; Wu, Y. J.; Wang, X. L.; Zhou, J.; Ma, L.
10.1101/2022.12.05.519110 — immunology — Posted on 2022-12-08
2985 Matrix Gla Protein acts as a driver of stemness and tumor initiation in ovarian cancer
Nieddu, V.; Melocchi, V.; Battistini, C.; Franciosa, G.; Lupia, M.; Stellato, C.; Bertalot, G.; Olsen, J. V.; Colombo, N.; Bianchi, F.; Cavallaro, U.
10.1101/2022.12.06.519263 — cancer biology — Posted on 2022-12-08
2988 MembraneFold: Visualising transmembrane protein structure and topology
Gutierrez, S.; Tyczynski, W. G.; Boomsma, W.; Teufel, F.; Winther, O.
10.1101/2022.12.06.518085 — bioinformatics — Posted on 2022-12-08
2990 A wide foodomics approach coupled with metagenomics elucidates the environmental signature of Protected Geographical Indication potatoes
Boutsika, A.; Michailidis, M.; Ganopoulou, M.; Dalakouras, A.; Skodra, C.; Xanthopoulou, A.; Stamatakis, G.; Samiotaki, M.; Tanou, G.; Moysiadis, T.; Angelis, L.; Bazakos, C.; Molassiotis, A.; Nianiou-Obeidat, I.; Mellidou, I.; Ganopoulos, I.
10.1101/2022.10.12.511727 — plant biology — Posted on 2022-12-08
2991 Identification and Characterization of ML321: a Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models that Predict Atypical Antipsychotic Activity
Free, R. B.; Nilson, A. N.; Boldizsar, N. M.; Doyle, T.; Rodriguiz, R. M.; Pogorelov, V. M.; Machino, M.; Lee, K. H.; Bertz, J. W.; Xu, J.; Lim, H. D.; Dulcey, A. E.; Mach, R. H.; Woods, J. H.; Lane, J. R.; Shi, L.; Marugan, J. J.; Wetsel, W. C.; Sibley, D. R.
10.1101/2022.11.14.516475 — pharmacology and toxicology — Posted on 2022-12-08
2992 Structural and biochemical insights into heterotetramer formation of oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
Tariq, M.; Ikeya, T.; Togashi, N.; Fairall, L.; Bueno-Alejo, C.; Kamei, S.; Romartinez-Alonso, B.; Muro Campillo, M. A.; Hudson, A. J.; Ito, Y.; Schwabe, J. W.; Dominguez, C.; Tanaka, K.
10.1101/2022.10.10.511529 — biochemistry — Posted on 2022-12-08
2993 Mild SARS-CoV-2 infection results in long-lasting microbiota instability
Upadhyay, V.; Suryawanshi, R.; Tasoff, P.; McCavitt-Malvido, M.; Kumar, G. R.; Murray, V.; Noecker, C.; Bisanz, J. E.; Hswen, Y.; Ha, C.; Sreekumar, B.; Chen, I. P.; Lynch, S. V.; Ott, M.; Lee, S.; Turnbaugh, P. J.
10.1101/2022.12.07.519508 — microbiology — Posted on 2022-12-08
2994 Cortical structure of neural synchrony and information flow during transition from wakefulness to light non-rapid eye movement sleep
Fan, J. M.; Kudo, K.; Verma, P.; Ranasinghe, K. G.; Morise, H.; Findlay, A. M.; Vossel, K. A.; Kirsch, H. E.; Raj, A.; Krystal, A. D.; Nagarajan, S. S.
10.1101/2022.03.09.483562 — bioengineering — Posted on 2022-12-08
2995 The Golgi complex is a regulatory hub for homologous recombination-mediated DNA repair.
Galea, G.; Kuodyte, K.; Khan, M. M.; Thul, P. J.; Neumann, B.; Lundberg, E.; Pepperkok, R.
10.1101/2022.10.17.512236 — cell biology — Posted on 2022-12-08
2998 From Multi-Allele Fish to Non-Standard Environments, How ZFIN Assigns Phenotypes, Human Disease Models, and Gene Expression Annotations to Genes
Bradford, Y. M.; Van Slyke, C. E.; Howe, D. G.; Fashena, D.; Frazer, K.; Martin, R.; Paddock, H.; Pich, C.; Ramachandran, S.; Ruzicka, L.; Singer, A.; Taylor, R.; Tseng, W.-C.; Westerfield, M.
10.1101/2022.12.05.519159 — bioinformatics — Posted on 2022-12-08
2999 Rapid Restoration of Cell Phenotype and Matrix Forming Capacity Following Transient Nuclear Softening
Locke, R. C.; Miller, L.; Lemmon, E. A.; Assi, S. S.; Jones, D.; Bonnevie, E. D.; Burdick, J. A.; Heo, S.-J.; Mauck, R.
10.1101/2022.12.05.519160 — genomics — Posted on 2022-12-08
3002 Extreme genome diversity and cryptic speciation in a harmful algal bloom forming eukaryote
Wisecaver, J. H.; Auber, R. P.; Pendleton, A. L.; Watervoort, N. F.; Fallon, T. R.; Riedling, O. L.; Manning, S. R.; Moore, B. S.; Driscoll, W. W.
10.1101/2022.10.25.513657 — evolutionary biology — Posted on 2022-12-08
3004 HLA-Glyco: A large-scale interrogation of the glycosylated immunopeptidome
Bedran, G.; Polasky, D. A.; Yi, H.; Yu, F.; da Veiga Leprevost, F.; Alfaro, J. A.; Cieslik, M.; Nesvizhskii, A. I.
10.1101/2022.12.05.519200 — immunology — Posted on 2022-12-08
3006 Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity.
Ripa, R.; Ballhysa, E.; Steiner, J.; Annibal, A.; Hochhard, N.; Latza, C.; Dolfi, L.; Calabrese, C.; Meyer, A.; Polidori, M. C.; Mueller, R.-U.; Antebi, A.
10.1101/2022.12.05.519139 — physiology — Posted on 2022-12-08
3007 3D-Mass Spectrometry Imaging of Micro-scale 3D Cell Culture Models in Cancer Research
Iakab, S. A.; Keller, F.; Schmidt, S.; Cordes, J.; Zhou, Q.; Cairns, J. J.; Fischer, F.; Schneider, R.; Wolf, I.; Rudolf, R.; Hopf, C.
10.1101/2022.12.05.519157 — cancer biology — Posted on 2022-12-08
3008 A Community Challenge to Predict Clinical Outcomes After Immune Checkpoint Blockade in Non-Small Cell Lung Cancer
Mason, M.; Lapuente-Santana, O.; Halkola, A. S.; Wang, W.; Mall, R.; Xiao, X.; Kaufman, J.; Fu, J.; Pfeil, J.; Banerjee, J.; Chung, V.; Chang, H.; Chasalow, S. D.; Lin, H. Y.; Chai, R.; Yu, T.; Finotello, F.; Mirtti, T.; Mayranpaa, M. I.; Bao, J.; Verschuren, E. W.; Ahmed, E. I.; Ceccarelli, M.; Miller, L. D.; Monaco, G.; Hendrickx, W. R. L.; Sherif, S.; Yang, L.; Tang, M.; Gu, S. S.; Zhang, W.; Zhang, Y.; Zeng, Z.; Sahu, A. D.; Liu, Y.; Yang, W.; Bedognetti, D.; Tang, J.; Eduati, F.; Laajala, T. D.; Geese, W. J.; Guinney, J.; Szustakowski, J. D.; Carbone, D. P.; Vincent, B. G.
10.1101/2022.12.05.518667 — cancer biology — Posted on 2022-12-08
3011 A natural single nucleotide mutation in the small regulatory RNA ArcZ of Dickeya solani switches off the antimicrobial activities against yeast and bacteria.
Brual, T.; Effantin, G.; Baltenneck, J.; Attaiech, L.; Grosbois, C.; Royet, M.; Cigna, J.; Faure, D.; Hugouvieux-Cotte-Pattat, N.; Gueguen, E.
10.1101/2021.07.19.452942 — microbiology — Posted on 2022-12-08
3018 Exploring the association between Body Mass Index, Sex and Gene Expression in human colorectal epithelium
Lemler, L.; Donnelly, K.; Tomlinson, I.; Timofeeva, M.; Theodoratou, E.; Rozadilla, C. F.; Fernandez-Tajes, J.; Grimes, G.; Farrington, S.; Dunlop, M.
10.1101/2022.11.21.515057 — genomics — Posted on 2022-12-08
3019 Multi-omics analysis identifies drivers of protein phosphorylation
Zhang, T.; Keele, G. R.; Gerdes Gyuricza, I.; Vincent, M.; Brunton, C.; Bell, T. A.; Hock, P.; Shaw, G. D.; Munger, S. C.; Pardo-Manuel de Villena, F.; Ferris, M. T.; Paulo, J. A.; Gygi, S. P.; Churchill, G. A.
10.1101/2022.06.03.494740 — genomics — Posted on 2022-12-08
3020 Non-allelic homologous recombination driven translocation explains histidine-rich protein 3 deletion mechanism in Plasmodium falciparum
Hathaway, N. J.; Kim, I. E.; Young, N. W.; Hui, S. T.; DeFeo, R.; Giesbrecht, D.; Liang, E. Y.; Nixon, C. P.; Juliano, J. J.; Parr, J. B.; Bailey, J. A.
10.1101/2022.12.07.519189 — genomics — Posted on 2022-12-08
3021 Extensive immune receptor repertoire diversity in disease-resistant rice landraces
Gladieux, P.; van Oosterhout, C.; Fairhead, S.; Jouet, A.; Ortiz, D.; Ravel, S.; Shrestha, R.-K.; Frouin, J.; He, X.; Zhu, Y.; Morel, J. B.; Huang, H.; Kroj, T.; Jones, J. D.
10.1101/2022.12.05.519081 — evolutionary biology — Posted on 2022-12-08
3022 Expanded olfactory system in fishes capable of terrestrial exploration
Burguera, D.; Dionigi, F.; Kverkov, K.; Winkler, S.; Brown, T.; Pippel, M.; Zhang, Y.; Shafer, M.; Nichols, A. L. A.; Myers, E.; Nemec, P.; Musilova, Z.
10.1101/2022.12.05.518831 — evolutionary biology — Posted on 2022-12-08
3023 The global biogeography of angiosperm genome size is shaped by climate and range size
Bures, P.; Elliott, T. L.; Vesely, P.; Smarda, P.; Forest, F.; Leitch, I. J.; Lughadha, E. N.; Gomez, M. S.; Pironon, S.; Brown, M. J. M.; Smerda, J.; Zedek, F.
10.1101/2022.12.05.519116 — evolutionary biology — Posted on 2022-12-08
3025 Discovery of a novel monoclonal PD-L1 antibody H1A that promotes T-cell mediated tumor killing activity in renal cell carcinoma
An, Z.; Hsu, M. A.; Gicobi, J. K.; Xu, T.; Harrington, S. M.; Zhang, H.; Pavelko, K. D.; Hirdler, J. B.; Lohse, C.; Nabavizadeh, R.; Pessoa, R. R.; Sharma, V.; Thompson, R. H.; Leibovich, B. C.; Dong, H.; Lucien, F.
10.1101/2022.09.10.507426 — immunology — Posted on 2022-12-08
3026 Lack of the glycine receptor alpha 2 increases striatal activity and motivated behavior
Devoght, J.; Comhair, J.; Morelli, G.; Rigo, J.-M.; D'Hooge, R.; Touma, C.; Palme, R.; Dewachter, I.; vandeVen, M.; Harvey, R. J.; Schiffmann, S.; Piccart, E.; Brone, B.
10.1101/2022.08.31.506020 — neuroscience — Posted on 2022-12-08
3028 Boosting wheat functional genomics via indexed EMS mutant library of KN9204
Wang, D.; Li, Y.; Wang, H.; Xu, Y.; Yang, Y.; Zhou, Y.; Chen, Z.; Zhou, Y.; Gui, L.; Guo, Y.; Zhou, C.; Tang, W.; Zheng, S.; Wang, L.; Guo, X.; Zhang, Y.; Cui, F.; Lin, X.; Jiao, Y.; He, Y.; Li, J.; He, F.; Liu, X.; Xiao, J.
10.1101/2022.12.05.519108 — plant biology — Posted on 2022-12-08
3030 ERBB-activated myofibroblastic cancer-associated fibroblasts promote local metastasis of pancreatic cancer
Mucciolo, G.; Araos Henriquez, J.; Pinto Teles, S.; Manansala, J. S.; Jihad, M.; Li, W.; Lloyd, E. G.; Cheng, P. S. W.; Biffi, G.
10.1101/2022.12.05.519080 — cancer biology — Posted on 2022-12-08
3031 Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia
Paiboonrungruang, C.; Xiong, Z.; Lamson, D.; Li, Y.; Bowman, B.; Chembo, J.; Huang, C.; Li, J.; Livingston, E. W.; Frank, J. E.; Chen, V.; Li, Y.; Weissman, B.; Yuan, H.; Williams, K. P.; Major, M.; Chen, X.
10.1101/2022.12.05.519147 — cancer biology — Posted on 2022-12-08
3032 SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status
Daley, B.; Vieira, H. M.; Rao, C.; Hughes, J.; Huisman, D. H.; Chatterjee, D.; Sealover, N. E.; Cox, K.; Askew, J. W.; Svoboda, R. A.; Fisher, K. W.; Lewis, R. E.; Kortum, R. L.
10.1101/2022.12.06.519395 — cancer biology — Posted on 2022-12-08
3034 Spatial frequency-based correction of the spherical aberration in living brain imaging
Gohma, A.; Adachi, N.; Horiba, D.; Yonemaru, Y.; Nishiwaki, D.; Yokoi, E.; Higuchi, K.; Ue, Y.; Miyawaki, A.; Monai, H.
10.1101/2022.12.05.519048 — biophysics — Posted on 2022-12-08
3035 A Meta-analysis of 2D vs. 3D Ovarian Cancer Cellular Models
Kerslake, R.; Belay, B.; Panfilov, S.; Hall, M.; Kyrou, I.; Randeva, H.; Hyttinen, J.; Karteris, E.; Sisu, C.
10.1101/2022.12.05.519144 — bioinformatics — Posted on 2022-12-08
3038 Structure of an endogenous mycobacterial MCE lipid transporter
Chen, J.; Fruhauf, A.; Fan, C.; Ponce, J.; Ueberheide, B.; Bhabha, G.; Ekiert, D. C.
10.1101/2022.12.08.519548 — biochemistry — Posted on 2022-12-08
3041 A Framework for Designing Efficient Deep Learning-Based Genomic Basecallers
Singh, G.; Alser, M.; Khodamoradi, A.; Denolf, K.; Firtina, C.; Cavlak, M. B.; Corporaal, H.; Mutlu, O.
10.1101/2022.11.20.517297 — genomics — Posted on 2022-12-08
3045 Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition
Ma, C.; Liu, C.; Xiong, Q.; Gu, M.; Shi, L.; Wang, C.; Si, J.; Tong, F.; Liu, P.; Huang, M.; Yan, H.
10.1101/2022.09.11.507506 — microbiology — Posted on 2022-12-08
3047 The spatial distribution and temporal trends of livestock damages caused by wolves in Europe
Singer, L.; Wietlisbach, X.; Hickisch, R.; Schoell, E. M.; Leuenberger, C.; Van den Broek, A.; Desalme, M.; Driesen, K.; Lyly, M.; Marucco, F.; Kutal, M.; Pagon, N.; Papp, C. R.; Milioni, P.; Uzdras, R.; Zihmanis, I.; Zimmermann, F.; Marsden, K.; Hackländer, K.; Lopez-Bao, J. V.; Klenzendorf, S.; Wegmann, D.
10.1101/2022.07.12.499715 — ecology — Posted on 2022-12-08
3048 Transcriptome responses of the aphid vector Myzus persicae are shaped by identities of the host plant and the virus
Chesnais, Q.; Golyaev, V.; Velt, A.; Rustenholz, C.; Verdier, M.; Brault, V.; Pooggin, M. M.; Drucker, M.
10.1101/2022.07.18.500449 — plant biology — Posted on 2022-12-08
3053 Expanding the HDAC druggable landscape beyond enzymatic inhibition
Olivet, J.; Choi, S. G.; Sierra, S.; O'Grady, T. M.; de la Fuente Revenga, M.; Laval, F.; Botchkarev, V. V.; Gorgulla, C.; Coote, P. W.; Blavier, J.; Geffken, E. A.; Lakhani, J.; Song, K.; Yeoh, Z. C.; Hu, B.; Varca, A. C.; Bruyr, J.; Ibrahim, S.; Jivanjee, T.; Bromley, J. D.; Nyquist, S. K.; Richardson, A.; Yue, H.; Wang, Y.; Calonghi, N.; Stephan, A.; Spirohn, K.; Vertommen, D.; Baietti, M. F.; Lemmens, I.; Seo, H.-S.; Dozmorov, M. G.; Willems, L.; Tavernier, J.; Das, K.; Leucci, E.; Hochkoeppler, A.; Sun, Z.-Y. J.; Calderwood, M. A.; Hao, T.; Shalek, A. K.; Hill, D. E.; Boeszoermenyi, A.; A
10.1101/2022.12.07.519454 — molecular biology — Posted on 2022-12-08
3054 Gallocin A, an atypical two-peptide bacteriocin secreted by Streptococcus gallolyticus subsp. gallolyticus
Proutiere, A.; du Merle, L.; Garcia-Lopez, M.; Leger, C.; Voegele, A.; Chenal, A.; Harrington, A.; Tal-Gan, Y.; Cokelaer, T.; Trieu-Cuot, P.; Dramsi, S.
10.1101/2022.12.05.519244 — microbiology — Posted on 2022-12-08
3055 Inducible CRISPRi-based operon silencing and selective in trans gene complementation in Borrelia burgdorferi
Murphy, B. T.; Wiepen, J. J.; He, H.; Pramanik, A. S.; Peters, J. M.; Stevenson, B.; Zueckert, W. R.
10.1101/2022.12.05.519228 — microbiology — Posted on 2022-12-08
3058 Optogenetic activation of visual thalamus generates artificial visual percepts
Wang, J.; Azimi, H.; Zhao, Y.; Kaeser, M.; Vaca Sanchez, P.; Harvey, M.; Rainer, G.
10.1101/2022.12.07.519434 — neuroscience — Posted on 2022-12-08
3059 Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury
Fuentes-Flores, A.; Geronimo-Olvera, C.; Necunir-Ibarra, D. S.; Patel, S. K.; Bons, J.; Wright, M. C.; Geschwind, D.; Höke, A.; Gomez-Sanchez, J. A.; Schilling, B.; Campisi, J.; Court, F. A.
10.1101/2022.12.07.519441 — neuroscience — Posted on 2022-12-08
3060 Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses
Chandra, R.; Farah, F.; Munoz-Lobato, F.; Bokka, A.; Benedetti, K. L.; Brueggemann, C.; Saifuddin, F. M.; Miller, J. M.; Li, J.; Chang, E.; Varshney, A.; Jiminez, V.; Baradwaj, A.; Nassif, C.; Alladin, S.; Andersen, K. E.; Bi, V.; Garcia, A. J.; Nordquist, S. K.; Dunn, R. L.; Tokalenko, K.; Soohoo, E.; Garcia, V.; Kaur, S.; Harris, M.; Briseno, F.; Fung, B.; Bykov, A.; Guillen, H.; Byrd, D.; Odisho, E.; Tsujimoto, B.; Tran, A.; Duong, A.; Daigle, K. C.; Paisner, R.; Zuazo, C. E.; Churgin, M.; Fang-Yen, C.; Bremer, M.; Kato, S.; L'Etoile, N. D.; VanHoven, M.
10.1101/2020.11.24.395228 — neuroscience — Posted on 2022-12-08
3062 Evolution Inspired Engineering of Megasynthetases
Bozhueyuek, K. A. J.; Praeve, L.; Kegler, C.; Kaiser, S.; Shi, Y.-N.; Kuttenlochner, W.; Schenk, L.; Mohiuddin, T. M.; Groll, M.; Hochberg, G. K. A.; Bode, H. B.
10.1101/2022.12.02.518901 — synthetic biology — Posted on 2022-12-08
3063 Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility
Sayaman, R. W.; Miyano, M.; Senapati, P.; Zirbes, A.; Shalabi, S.; Todhunter, M. E.; Seewaldt, V.; Neuhausen, S. L.; Stampfer, M. R.; Schones, D. E.; LaBarge, M. A.
10.1101/2022.09.22.509091 — cancer biology — Posted on 2022-12-08
3065 The mobility of the cap domain is essential for the substrate promiscuity of a family IV esterase from sorghum rhizosphere microbiome
Distaso, M.; Cea-Rama, I.; Coscolin, C.; Chernikova, T. N.; Tran, H.; Ferrer, M.; Sanz-Aparicio, J.; Golyshin, P. N.
10.1101/2022.09.10.507389 — biochemistry — Posted on 2022-12-08
3067 Top-down effects in motor generalization
Poh, E.; Al-Fawakhiri, N.; Tam, R.; Taylor, J. A.; McDougle, S. D.
10.1101/2021.02.09.430542 — neuroscience — Posted on 2022-12-07
3075 The effectiveness of acellular nerve allografts compared to autografts in animal models: a systematic review and meta-analysis
Broeren, B. O.; Hundepool, C. A.; Kumas, A. H.; Duraku, L. S.; Walbeehm, E. T.; Hooijmans, C. R.; Power, D. M.; Zuidam, J. M.; De Jong, T.
10.1101/2022.12.06.519361 — neuroscience — Posted on 2022-12-07
3076 Human hippocampal ripples signal encoding of episodic memories
Sakon, J. J.; Halpern, D. J.; Schonhaut, D. R.; Kahana, M. J.
10.1101/2022.10.03.510672 — neuroscience — Posted on 2022-12-07
3082 Genetic Mapping of Progressive Ethanol Consumption in the Diversity Outbred Mouse
Tatom, Z.; Mignogna, K. M.; Sergi, Z.; Nguyen, J.; Michenkova, M.; Smith, M. L.; Miles, M. F.
10.1101/2022.12.06.519344 — genetics — Posted on 2022-12-07
3085 Identification of a Female-produced Sex Attractant Pheromone of the Winter Firefly, Photinus corrusca
Lower, S. E.; Pask, G. M.; Arriola, K.; Halloran, S.; Holmes, H.; Halley, D. C.; Zheng, Y.; Collins, D. B.; Millar, J. G.
10.1101/2022.12.07.519461 — ecology — Posted on 2022-12-07
3086 Aging Fly Cell Atlas Identifies Exhaustive Aging Features at Cellular Resolution
Lu, T.-C.; Brbic, M.; Park, Y.-J.; Jackson, T.; Chen, J.; Kolluru, S. S.; Qi, Y.; Katheder, N. S.; Cai, X. T.; Lee, S.; Chen, Y.-C.; Auld, N.; Welsch, D.; D'Souza, S.; Pisco, A. O.; Jones, R. C.; Leskovec, J.; Lai, E. C.; Bellen, H. J.; Luo, L.; Jasper, H.; Quake, S. R.; Li, H.
10.1101/2022.12.06.519355 — developmental biology — Posted on 2022-12-07
3089 Pseudomonas aeruginosa contracts mucus to form biofilms in tissue-engineered human airways
Rossy, T.; Distler, T.; Pezoldt, J.; Kim, J.; Tala, L.; Bouklas, N.; Deplancke, B.; Persat, A.
10.1101/2022.05.26.493615 — microbiology — Posted on 2022-12-07
3090 Distinct subpopulations of DN1 thymocytes exhibit preferential γδ T lineage potential
Oh, S.; Liu, X.; Tomei, S.; Luo, M.; Skinner, J.; Berzins, S. P.; Naik, S. H.; Gray, D. H.; Chong, M. M.
10.1101/2022.02.25.481936 — immunology — Posted on 2022-12-07
3091 Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.
O'Meara, T. R.; Nanishi, E.; McGrath, M. E.; Barman, S.; Dong, D.; Dillen, C.; Menon, M.; Seo, H.-S.; Dhe-Paganon, S.; Ernst, R. K.; Levy, O.; Frieman, M. B.; Dowling, D. J.
10.1101/2022.12.07.519460 — immunology — Posted on 2022-12-07
3101 A first-in-class Wiskott-Aldrich syndrome protein (WASp) activator with anti-tumor activity in hematological cancers
Spriano, F.; Sartori, G.; Barnabei, L.; Arribas, A. J.; Guala, M.; Carrasco del Amor, A. M.; Tomasso, M. R.; Tarantelli, C.; Cascione, L.; Golino, G.; Riveiro, M. E.; Bortolozzi, R.; Lupia, A.; Paduano, F.; Huguet, S.; Rezai, K.; Margheriti, F.; Ventura, P.; Guarda, G.; Costa, G.; Rocca, R.; Cavalli, A.; Viola, G.; Driessen, C.; Zucca, E.; Stathis, A.; Bornhauser, B.; Alcaro, S.; Trapasso, F.; Cristobal, S.; Padrick, S. B.; Pazzi, N.; Cavalli, F.; Bertoni, F.; Gaudio, E.
10.1101/2022.11.25.517686 — cancer biology — Posted on 2022-12-07
3102 RNA conformational propensities determine cellular activity
Kelly, M. L.; Roy, R.; Geng, A.; Ganser, L. R.; Manghrani, A.; Cullen, B. R.; Schulze-Gahmen, U.; Herschlag, D.; Al-Hashimi, H. M.
10.1101/2022.12.05.519207 — biophysics — Posted on 2022-12-07
3103 Mega-scale experimental analysis of protein folding stability in biology and protein design
Tsuboyama, K.; Dauparas, J.; Chen, J.; Mangan, N. M.; Ovchinnikov, S.; Rocklin, G. J.
10.1101/2022.12.06.519132 — biophysics — Posted on 2022-12-07
3108 Engineered retrovirus-like Arc extracellular vesicles for the in vivo targeted delivery of mRNA into the brain
Gu, W.; Luozhong, S.; Londhe, K.; Cai, S.; Elkasri, N.; Hawkins, R.; Yuan, Z.; Su-Greene, K.; Cruz, M.; Chang, Y.-W.; McMullen, P.; Wu, C.; Seo, C.; Guru, A.; Gao, W.; Sarmiento, T.; Schaffer, C.; Nishimura, N.; Cerione, R.; Warden, M.; Langer, R.; Jiang, S.
10.1101/2022.12.07.518870 — bioengineering — Posted on 2022-12-07
3110 Socially tolerant macaques use more complex facial behavior than intolerant macaques
Rincon, A. V.; Waller, B. M.; Duboscq, J.; Mielke, A.; Perez, C.; Clark, P. R.; Micheletta, J.
10.1101/2022.12.07.519469 — animal behavior and cognition — Posted on 2022-12-07
3111 Poverty shapes the transcriptome of immune cells
Arnold, N. S.; Resztak, J.; Alazizi, A.; Hooten, N. N.; Evans, M. K.; Odera-Marah, V.; Dluzen, D. F.; Pique-Regi, R.; Luca, F.
10.1101/2022.12.06.517536 — genomics — Posted on 2022-12-07
3113 Associations of Socioeconomic Disparities With Buccal DNA-Methylation Measures Of Biological Aging
Raffington, L.; Schwaba, T.; Aikins, M.; Richter, D.; Wagner, G. G.; Harden, K. P.; Belsky, D. W.; Tucker-Drob, E. M.
10.1101/2022.12.07.519438 — developmental biology — Posted on 2022-12-07
3114 Pleiotropy of autism-associated chromatin regulators
Lasser, M.; Sun, N.; Xu, Y.; Law, K.; Gonzalez, S.; Wang, B.; Drury, V.; Drake, S.; Zaltsman, Y.; Dea, J.; Bader, E.; McCluskey, K. E.; State, M. W.; Willsey, A. J.; Willsey, H. R.
10.1101/2022.12.07.519375 — developmental biology — Posted on 2022-12-07
3115 New enhancer-promoter interactions are gained during tissue differentiation and reflect changes in E/P activity
Pollex, T.; Rabinowitz, A.; Gambetta, M. C.; Marco-Ferreres, R.; Viales, R. R.; Jankowski, A.; Schaub, C.; Furlong, E.
10.1101/2022.12.07.519443 — developmental biology — Posted on 2022-12-07
3116 Disruption of fos causes craniofacial anomalies in developing zebrafish
Maili, L.; Tandon, B.; Yuan, Q.; Menezes, S.; Hashmi, S. S.; Letra, A.; Eisenhoffer, G. T.; Hecht, J. T.
10.1101/2022.12.06.519379 — developmental biology — Posted on 2022-12-07
3117 Production and Characterization of Monoclonal antibodies to Xenopus Proteins
Horr, B.; Kurtz, R.; Pandey, A.; Hoffstrom, B.; Schock, E.; La Bonne, C.; Alfandari, D. R.
10.1101/2022.12.06.519341 — developmental biology — Posted on 2022-12-07
3118 Non-Canonical Functions of a Mutant TSC2 Protein in Mitotic Division
Chalkley, M.-B. L.; Mersfelder, R. B.; Sundberg, M.; Armstrong, L.; Sahin, M.; Ihrie, R. A.; Ess, K.
10.1101/2022.12.07.519401 — cell biology — Posted on 2022-12-07
3122 Selection for insecticide resistance can promote Plasmodium falciparum infection in Anopheles
Adams, K. L.; Willett, B. C.; Selland, E. K.; Carew, J. W.; Vidoudez, C.; Singh, N.; Catteruccia, F.
10.1101/2022.12.07.516767 — molecular biology — Posted on 2022-12-07
3126 Meta-omics profiling of full-scale groundwater rapid sand filters explains stratification of iron, ammonium and manganese removals
Corbera-Rubio, F.; Laureni, M.; Koudijs, N.; Muller, S.; van Alen, T.; Schoonenberg, F.; Luecker, S.; Pabst, M.; van Loosdrecht, M.; van Halem, D.
10.1101/2022.12.07.519464 — microbiology — Posted on 2022-12-07
3127 Molecular mechanisms regulating the pH-dependent pr/E interaction in yellow fever virus.
Crampon, E.; Covernton, E.; Vaney, M.-C.; Dellarole, M.; Sharma, A.; Haouz, A.; England, P.; Lepault, J.; Duquerroy, S.; Rey, F. A.; Barba Spaeth, G.
10.1101/2022.12.06.519383 — microbiology — Posted on 2022-12-07
3128 Hiding in the yolk: a unique feature of Legionella pneumophila infection of zebrafish
Viana, F.; Boucontet, L.; Schator, D.; Laghi, V.; Ibranosyan, M.; Jarraud, S.; Colucci-Guyon, E.; Buchrieser, C.
10.1101/2021.10.18.464513 — microbiology — Posted on 2022-12-07
3129 Characterization of BoHV-4 ORF45
Donofrio, G.; Russo, L.; Capra, E.; Franceschi, V.; Cavazzini, D.; Sala, R.; Lazzari, B.; Cavirani, S.
10.1101/2022.12.07.519449 — microbiology — Posted on 2022-12-07
3131 A Binary RNA and DNA Self-Amplifying Platform for Next Generation Vaccines and Therapeutics
Jefferies, W.; Choi, K. B.; Ribeca, P.; Kari, S.; Young, J.; Hui, E.; Qi, S. Y.; Garrosvillas, E.; Lincez, P.; Welch, T.; Saranchova, I.; Pfeifer, C. G.
10.1101/2022.12.06.519322 — immunology — Posted on 2022-12-07
3132 Hypo-responsiveness of human alveolar macrophages to IFN-γ is not due to attenuated STAT1 signaling
Thiel, B. A.; Lundberg, K. C.; Schlatzer, D.; Jarvela, J.; Li, Q.; Shaw, R.; Beckloff, S. E.; Chance, M. R.; Boom, W. H. A.; Silver, R. F.; Bebek, G.
10.1101/2022.12.07.519298 — immunology — Posted on 2022-12-07
3135 Cerebral organoids expressing mutant actin genes reveal cellular mechanism underlying microcephalic cortical malformation
Niehaus, I.; Wilsch-Braeuninger, M.; Mora-Bermudez, F.; Bobic-Rasonja, M.; Radosevic, V.; Milkovic-Perisa, M.; Wimberger, P.; Severino, M.; Haase, A.; Martin, U.; Kuenzel, K.; Guan, K.; Neumann, K.; Walker, N.; Schrock, E.; Jovanov-Milosevic, N.; Huttner, W. B.; Di Donato, N.; Heide, M.
10.1101/2022.12.07.519435 — neuroscience — Posted on 2022-12-07
3136 bII-spectrin is required for synaptic positioning during retinal development
Zuniga-Sanchez, E.; Goswami-Sewell, D.; Bagnetto, C.; Anderson, J. T.; Maheshwari, A.
10.1101/2022.12.07.519458 — neuroscience — Posted on 2022-12-07
3140 Asymmetric coding of reward prediction errors in human insula and dorsomedial prefrontal cortex
Hoy, C. W.; Quiroga-Martinez, D. R.; King-Stephens, D.; Laxer, K.; Weber, P.; Lin, J. J.; Knight, R. T.
10.1101/2022.12.07.519496 — neuroscience — Posted on 2022-12-07
3141 Trans-cellular control of synapse properties by a cell type-specific splicing regulator
Traunmuller, L.; Schulz, J. M.; Ortiz, R.; Feng, H.; Furlanis, E.; Gomez, A. M.; Schreiner, D.; Bischofberger, J.; Zhang, C.; Scheiffele, P.
10.1101/2022.12.07.519444 — neuroscience — Posted on 2022-12-07
3142 Controlling the bioelectrical properties of neurons with ferritin-based Magnetogenetics
HERNANDEZ-MORALES, M.; MORALES-WEIL, K.; HAN, S. M.; HAN, V.; PEGRAM, K.; BENNER, E. J.; MILLER, E. W.; KRAMER, R. H.; LIU, C.
10.1101/2022.12.07.519516 — neuroscience — Posted on 2022-12-07
3146 Pynapple: a toolbox for data analysis in neuroscience.
Viejo, G.; Levenstein, D.; Carrasco, S. S.; Mehrotra, D.; Mahallati, S.; Vite, G. R.; Denny, H.; Sjulson, L.; Battaglia, F. P.; Peyrache, A.
10.1101/2022.12.06.519376 — neuroscience — Posted on 2022-12-07
3149 Early selection of the amino acid alphabet was adaptively shaped by biophysical constraints of foldability
Makarov, M.; Rocha, A. C. S.; Krystufek, R.; Cherepashuk, I.; Dzmitruk, V.; Charnavets, T.; Faustino, A. M.; Lebl, M.; Fujishima, K.; Fried, S. D.; Hlouchova, K.
10.1101/2022.06.14.495995 — biophysics — Posted on 2022-12-07
3150 A deep learning and digital archaeology approach for mosquito repellent discovery
Wei, J. N.; Vlot, M.; Sanchez-Lengeling, B.; Lee, B. K.; Berning, L.; Vos, M. W.; Henderson, R. W.; Qian, W. W.; Ando, D. M.; Groetsch, K. M.; Gerkin, R. C.; Wiltschko, A. B.; Dechering, K. J.
10.1101/2022.09.01.504601 — bioengineering — Posted on 2022-12-07
3152 Structure of a reversible amyloid fibril formed by the CPEB3 prion-like domain reveals a core sequence involved in translational regulation
Flores, M. D.; Sawaya, M. R.; Boyer, D. R.; Zink, S.; Tovmasyan, S.; Saucedo, A.; Zee, C.-T.; Cardenas, J.; Fioriti, L.; Rodriguez, J. A.
10.1101/2022.12.07.519389 — biochemistry — Posted on 2022-12-07
3153 The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice
Tran, T. D. B.; Hernandez, C. J. M.; Nguyen, H.; Wright, S.; Center for Systems Neurogenetics of Addiction, ; Tarantino, L. M.; Chesler, E. J.; Zhou, Y.; Weinstock, G.; Bubier, J. A.
10.1101/2022.12.06.519360 — animal behavior and cognition — Posted on 2022-12-07
3154 3D Imaging Reveals Resilience: Storm Impact on Coral Reef Structural Complexity
Yuval, M.; Pearl, N.; Tchernov, D.; Loya, Y.; Bar-Massada, A.; Treibitz, T.
10.1101/2022.12.04.519015 — ecology — Posted on 2022-12-07
3157 Brain-wide oscillatory network selectively encodes aggression
Grossman, Y. S.; Talbot, A.; Gallagher, N. M.; Thomas, G.; Fink, A. J.; Walder-Christensen, K. K.; Russo, S.; Carlson, D. E.; Dzirasa, K.
10.1101/2022.12.07.519272 — neuroscience — Posted on 2022-12-07
3158 Guidelines for extracting biologically relevant context-specific metabolic models using gene expression data
Gopalakrishnan, S.; Joshi, C. J.; Valderrama Gomez, M.; Icten, E.; Rolandi, P.; Johnson, W.; Kontoravdi, C.; Lewis, N. E.
10.1101/2022.12.04.519052 — systems biology — Posted on 2022-12-07
3169 Visualizing somatic alterations in spatial transcriptomics data of skin cancer
Chen, L.; Chang, D.; Tandukar, B.; Deivendran, D.; Cho, R.; Cheng, J.; Bastian, B. C.; Ji, A. L.; Shain, A. H.
10.1101/2022.12.05.519162 — genomics — Posted on 2022-12-07
3173 Rewiring Cancer Drivers to Activate Apoptosis
Gourisankar, S. P.; Krokhotin, A.; Ji, W.; Liu, X.; Chang, C.-y.; Kim, S. H.; Li, Z.; Wenderski, W.; Simanauskaite, J. M.; Zhang, T.; Gray, N. S.; Crabtree, G. R.
10.1101/2022.12.04.517548 — cancer biology — Posted on 2022-12-07
3174 Monopogen: single nucleotide variant calling from single cell sequencing
Dou, J.; Tan, Y.; Kock, k. H.; Wang, J.; Cheng, X.; Tan, L. M.; Han, K. Y.; Hon, C.-C.; Park, W. Y.; Shin, J. W.; Chen, H.; Prabhakar, S.; Navin, N.; Chen, R.; Chen, K.
10.1101/2022.12.04.519058 — bioinformatics — Posted on 2022-12-07
3176 Outbreak.info Research Library: A standardized, searchable platform to discover and explore COVID-19 resources
Tsueng, G.; Mullen, J.; Alkuzweny, M.; Cano, M. A.; Rush, B.; Haag, E.; Outbreak Curators, ; Lin, J.; Welzel, D. J.; Zhou, X.; Qian, Z.; Latif, A. A.; Hufbauer, E.; Zeller, M.; Andersen, K. G.; Wu, C.; Su, A. I.; Gangavarapu, K.; Hughes, L. D.
10.1101/2022.01.20.477133 — bioinformatics — Posted on 2022-12-07
3177 Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1
Nicoli, A.; Haag, F.; Marcinek, P.; He, R.; Kreissl, J.; Stein, J.; Marchetto, A.; Dunkel, A.; Hofmann, T.; Krautwurst, D.; Di Pizio, A.
10.1101/2022.06.01.494157 — molecular biology — Posted on 2022-12-07
3178 Unsupervised reference-free inference reveals unrecognized regulated transcriptomic complexity in human single cells
Dehghannasiri, R.; Henderson, G.; Bierman, R.; Chaung, K.; Baharav, T. Z.; Wang, P. L.; Salzman, J.
10.1101/2022.12.06.519414 — bioinformatics — Posted on 2022-12-07
3181 Mutual regulation between GDF11 and TET2 prevents senescence of mesenchymal stem cells
Gao, J.; Wang, H.; Shen, J.; Liu, X.; Zhu, X.; Zhao, E.; Li, G.; Sun, Y.; Yin, F.; Liu, Z.; Sun, Y. E.; Liu, H.
10.1101/2020.03.30.008722 — cell biology — Posted on 2022-12-07
3183 Impacts of ocean acidification and warming on post-larval growth and metabolism in two populations of the great scallop (Pecten maximus L.)
Harney, E.; Rastrick, S. P. S.; Artigaud, S.; Pisapia, J.; Bernay, B.; Miner, P.; Pichereau, V.; Strand, O.; Boudry, P.; Charrier, G.
10.1101/2022.12.02.518857 — evolutionary biology — Posted on 2022-12-07
3185 The large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila
Hüsler, D.; Stauffer, P.; Keller, B.; Böck, D.; Steiner, T.; Ostrzinski, A.; Striednig, B.; Swart, L.; Letourneur, F.; Maass, S.; Becher, D.; Eisenreich, W.; Pilhofer, M.; Hilbi, H.
10.1101/2022.12.05.519141 — microbiology — Posted on 2022-12-07
3186 Podoplanin expression in fibroblasts determines lymph node architecture and adaptive immune function
Makris, S.; Hari-Gupta, Y.; Cantoral-Rebordinos, J. A.; Martinez, V. G.; Horsnell, H. L.; de Winde, C. M.; Singh, T.; Jovancheva, M.; Kettler, R.; Kriston-Vizi, J.; Acton, S. E.
10.1101/2022.12.01.518753 — immunology — Posted on 2022-12-07
3187 Organization, genomic targeting and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis
Fu, W.; Yu, Y.; Shu, J.; Yu, Z.; Zhu, T.; Zhong, Y.; Zhang, Z.; Liang, Z.; Cui, Y.; Chen, C.; Li, C.
10.1101/2022.11.24.517835 — plant biology — Posted on 2022-12-07
3188 A Rigid Parallel-Plate Oxygenator Prototype with a Computational Fluid Dynamics Informed Blood Flow Path for Artificial Placenta Applications
Blauvelt, D. G.; Higgins, N.; De, B.; Goodin, M. S.; Wright, N.; Blaha, C.; Moyer, J.; Chui, B.; Baltazar, F.; Oishi, P.; Roy, S.
10.1101/2022.08.23.505025 — bioengineering — Posted on 2022-12-07
3191 eDNA metabarcoding vs metagenomics: an assessment of dietary competition in two estuarine pipefishes
Serite, C. P.; Emami-Khoyi, A.; Ntshudisane, O. K.; James, N. C.; Jansen van Vuuren, B.; Bodill, T.; Cowley, P. D.; Whitfield, A.; Teske, P.
10.1101/2021.01.05.425398 — ecology — Posted on 2022-12-07
3193 The ER protein translocation channel subunit Sbh1 controls virulence of Cryptococcus neoformans
Santiago-Tirado, F. H.; Hurtaux, T.; Geddes-McAlister, J.; Nguyen, D.; Helms, V.; Doering, T. L.; Romisch, K.
10.1101/2022.06.01.494298 — microbiology — Posted on 2022-12-07
3194 Increased migratory/activated CD8+ T cell and low avidity SARS-CoV-2 reactive cellular response in post-acute COVID-19 syndrome
Paniskaki, K.; Konik, M.; Anft, M.; Heidecke, H.; Meister, T.; Pfaender, S.; Krawczyk, A.; Zettler, M.; Jäger, J.; Gaeckler, A.; Dolff, S.; Westhoff, T.; Rohn, H.; Stervbo, U.; Scheibenbogen, C.; Witzke, O.; Babel, N.
10.1101/2022.12.03.519007 — immunology — Posted on 2022-12-07
3195 Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease
Serrano-Pozo, A.; Li, Z.; Woodbury, M. E.; Munoz-Castro, C.; Wachter, A.; Jayakumar, R.; Bryant, A. G.; Noori, A.; Welikovitch, L. A.; Hu, M.; Liao, F.; Lin, G.; Pastika, T.; Tamm, J.; Abdourahman, A.; Kwon, T.; Bennett, R. E.; Talanian, R. V.; Biber, K.; Karran, E. H.; Hyman, B. T.; Das, S.
10.1101/2022.12.03.518999 — neuroscience — Posted on 2022-12-07
3196 Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous ECM
Martins-Costa, C.; Pham, V.; Sidhaye, J.; Novatchkova, M.; Peer, A.; Moeseneder, P.; Corsini, N. S.; Knoblich, J. A.
10.1101/2022.12.06.519271 — developmental biology — Posted on 2022-12-07
3197 Convergent deployment of ancestral programs during the evolution of mammalian flight membranes
Feigin, C. Y.; Moreno, J. A.; Ramos, R.; Mereby, S. A.; Alivisatos, A.; Wang, W.; van Amerongen, R.; Camacho, J.; Rasweiler, J. J.; Behringer, R.; Ostrow, B.; Plikus, M. V.; Mallarino, R.
10.1101/2022.12.06.518272 — developmental biology — Posted on 2022-12-07
3199 Distinguishing Happiness and Meaning in Life from Depressive Symptoms: a GWAS-by-subtraction study in the UK Biobank
de Vries, L. P.; Demange, P. A.; Baselmans, B. M. L.; Vinkers, C. H.; Pelt, D. H. M.; Bartels, M.
10.1101/2022.12.06.519260 — genetics — Posted on 2022-12-07
3202 High-throughput mapping of single-cell molecular and projection architecture of neurons by retrograde barcoded labelling
Xu, P.; Peng, J.; Yuan, T.; Chen, Z.; He, H.; Wu, Z.; Li, T.; Li, X.; Wang, L.; Wei, W.; Li, C. T.; Luo, Z.-G.; Chen, Y.
10.1101/2021.05.16.444258 — neuroscience — Posted on 2022-12-06
3204 snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profiling
Vallejo, A. F.; Harvey, K.; Wang, T.; Wise, K.; Butler, L. M.; Polo, J.; Plummer, J. T.; Swarbrick, A.; Martelotto, L. G.
10.1101/2022.08.23.505054 — cancer biology — Posted on 2022-12-06
3205 Cost-effective hybrid long-short read assembly delineates alternative GC-rich Streptomyces chassis for natural product discovery
Heng, E.; Tan, L. L.; Tay, D. W. P.; Lim, Y. H.; Yang, L.-K.; Seow, D. C. S.; Leong, C. Y.; Ng, V.; Ng, S. B.; Kanagasundaram, Y.; Wong, F. T.; Koduru, L.
10.1101/2022.12.05.519232 — genomics — Posted on 2022-12-06
3206 Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision
Vromman, M.; Anckaert, J.; Bortoluzzi, S.; Buratin, A.; Chen, C.-Y.; Chu, Q.; Chuang, T.-J.; Dehghannasiri, R.; Dieterich, C.; Dong, X.; Flicek, P.; Gaffo, E.; Gu, W.; He, C.; Hoffmann, S.; Izuogu, O.; Jackson, M. S.; Jakobi, T.; Lai, E. C.; Nuytens, J.; Salzman, J.; Santibanez-Koref, M.; Stadler, P.; Thas, O.; Vanden Eynde, E.; Verniers, K.; Wen, G.; Westholm, J.; Yang, L.; Ye, C.-Y.; Yigit, N.; Yuan, G.-H.; Zhang, J.; Zhao, F.; Vandesompele, J.; Volders, P.-J.
10.1101/2022.12.06.519083 — genomics — Posted on 2022-12-06
3207 Integrating genetic and oral histories of Southwest Indian populations
Biddanda, A.; Bandyopadhyay, E.; de la Fuente Castro, C.; Witonsky, D.; Pasupuleti, N.; Fonseca, R.; Freilich, S.; Moots, H. M.; Stanisavic, J.; Willis, T.; Menon, A.; Mustak, M. S.; Kodira, C. D.; Naren, A. P.; Sikdar, M.; Rai, N.; Raghavan, M.
10.1101/2022.07.06.498959 — genetics — Posted on 2022-12-06
3210 Histone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity
Zheng, Q.; Bastle, R. M.; Zhao, S.; Kong, L.; Vostal, L.; Ramakrishnan, A.; Shen, L.; Fulton, S. L.; Wang, H.; Zhang, B.; Thompson, R. E.; Molina, H.; Stransky, S.; Sidoli, S.; Muir, T. W.; Li, H.; David, Y.; Maze, I.
10.1101/2022.12.06.519310 — molecular biology — Posted on 2022-12-06
3211 Heterogeneity in the M. tuberculosis β-lactamase inhibition by Sulbactam
Malla, T. N.; Zielinkski, K. A.; Aldama, L.; Bajt, S.; Feliz, D.; Hayes, B.; Hunter, M.; Kupitz, C.; Lisova, S.; Knoska, J.; Mariani, V.; Martin-Garcia, J.; Pandey, S.; Poudyal, I.; Sierra, R. G.; Tolstikova, A.; Yefanov, O.; Yoon, C. H.; Ourmazd, A.; Fromme, P.; Schwander, P.; Barty, A.; Chapman, H. N.; Stojkovic, E. A.; Batjuk, A.; Boutet, S.; Phillips, G. N.; Pollack, L.; Schmidt, M.
10.1101/2022.12.06.519319 — molecular biology — Posted on 2022-12-06
3213 Novel populations of Tr1 cells contribute to the resolution of acute influenza A virus infection.
Abbott, C. A.; Freimayer, E. L.; Tyllis, T. S.; Norton, T. S.; Alsharifi, M.; Heng, A. H.; Pederson, S. M.; Qu, Z.; Armstrong, M.; Hill, G. R.; McColl, S. R.; Comerford, I.
10.1101/2022.12.06.519368 — immunology — Posted on 2022-12-06
3216 Mega-scale experimental analysis of protein folding stability in biology and protein design
Tsuboyama, K.; Dauparas, J.; Chen, J.; Mangan, N. M.; Ovchinnikov, S.; Rocklin, G. J.
10.1101/2022.12.06.519132 — biophysics — Posted on 2022-12-06
3217 Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs)
Kotliar, I. B.; Ceraudo, E.; Kemelmakher-Liben, K.; Oren, D. A.; Lorenzen, E.; Dodig-Crnkovic, T.; Horioka-Duplix, M.; Huber, T.; Schwenk, J. M.; Sakmar, T. P.
10.1101/2022.12.06.519316 — biochemistry — Posted on 2022-12-06
3220 Structural Model for Self-Limiting β-strand Arrangement Within an Alzheimer's Amyloid-β Oligomer
Gao, Y.; Prasad, R.; Randolph, P. S.; Watzlawik, J. O.; Roband, A. S.; Guo, C.; Stagg, S. M.; Zhou, H.-X.; Rosenberry, T. L.; Paravastu, A. K.
10.1101/2022.12.06.519347 — biochemistry — Posted on 2022-12-06
3221 Substrate profiling of the metalloproteinase ovastacin - Implications for its physiological function in mammalian fertilization
Felten, M.; Distler, U.; von Wiegen, N.; Łacki, M.; Behl, C.; Tenzer, S.; Stöcker, W.; Körschgen, H.
10.1101/2022.12.06.519252 — biochemistry — Posted on 2022-12-06
3225 8-HQA Adjusts the Number and Diversity of Bacteria in the Gut Microbiome of Spodoptera littoralis
Mazumdar, T.; Haenniger, S.; Shukla, S.; Murali, A.; Bartram, S.; Heckel, D. G.; Boland, W.
10.1101/2022.12.06.519313 — microbiology — Posted on 2022-12-06
3226 Distribution and environmental drivers of fungal denitrifiers in global soils
Bosch, Y.; Pold, G.; Saghai, A.; Karlsson, M.; Jones, C. M.; Hallin, S.
10.1101/2022.12.06.519296 — microbiology — Posted on 2022-12-06
3227 Unexpected finding of Fusobacterium varium abundance in cattle rumen: implications for liver abscess interventions
Schwarz, C.; Mathieu, J.; Gomez, J. L.; Tikhonova, M.; Miller, M. R.; Nagaraja, T. G.; Alvarez, P. J. J.
10.1101/2022.12.05.519234 — microbiology — Posted on 2022-12-06
3230 Sniper2L, a high-fidelity Cas9 variant with high activity
Kim, Y.-h.; Kim, N.; Okafor, I.; Choi, S.; Min, S.; Lee, J.; Choi, K.; Choi, J.; Harihar, V.; Kim, Y.; Kim, J.-S.; Lee, J. K.; Ha, T.; Kim, H. H.
10.1101/2022.12.05.519240 — bioengineering — Posted on 2022-12-06
3233 Cellular production of a de novo membrane cytochrome
Hardy, B. J.; Martin Hermosilla, A.; Chinthapalli, D. K.; Anderson, R.; Robinson, C. V.; Curnow, P.
10.1101/2022.12.06.519282 — biochemistry — Posted on 2022-12-06
3236 The development of intracytoplasmic membranes in alphaproteobacteria involves the conserved mitochondrial crista-developing protein Mic60
Munoz-Gomez, S. A.; Cadena, L. R.; Gardiner, A. T.; Leger, M. M.; Sheikh, S.; Connell, L.; Bily, T.; Kopejtka, K.; Beatty, J. T.; Koblizek, M.; Roger, A. J.; Slamovits, C. H.; Lukes, J.; Hashimi, H.
10.1101/2022.06.14.496148 — evolutionary biology — Posted on 2022-12-06
3239 Probing the genetic code and impacts of mistranslation using tRNAAla anticodon variants
Cozma, E.; Rao, M.; Dusick, M.; Genereaux, J.; Rodriguez-Mias, R. A.; Villen, J.; Brandl, C. J.; Berg, M. D.
10.1101/2022.11.23.517754 — molecular biology — Posted on 2022-12-06
3242 What is learned determines how Pavlovian conditioned fear is consolidated in the brain.
Leake, J.; Leidl, D. M.; Lay, B. P. P.; Fam, J. P.; Giles, M. C.; Qureshi, O. A.; Westbrook, R. F.; Holmes, N. M.
10.1101/2022.12.05.519226 — animal behavior and cognition — Posted on 2022-12-06
3247 Syngap1 Regulates Cortical Circuit Assembly by Controlling Membrane Excitability
Arora, V.; Michaelson, S.; Aceti, M.; Klinik, M.; Miller, C.; Rumbaugh, G.
10.1101/2022.12.06.519295 — neuroscience — Posted on 2022-12-06
3255 Fractions strategy differences in those born extremely preterm
Carr, S.; Babinchak, W. M.; Istrate, A.; Martyn-Dow, B.; Wang, G.; Chen, W.; Fondran, J.; Zhang, J.; Wein, M.; Yoon, S. Y.; Birnbaum, A.; Roth, E.; Gross, C.; Minich, N.; Thompson, L.; Kim, W. H.; Stern, Y.; Nosarti, C.; Taylor, H. G.; Tatsuoka, C.
10.1101/2022.12.06.519175 — neuroscience — Posted on 2022-12-06
3257 Aβ-CT affective touch: Touch pleasantness ratings for gentle stroking and deep pressure exhibit dependence on A-fibers
Case, L.; Madian, N.; McCall, M.; Bradson, M.; Liljencrantz, J.; Goldstein, B.; Alasha, V.; Zimmerman, M.
10.1101/2022.12.06.518627 — neuroscience — Posted on 2022-12-06
3258 Layer-dependent activity in the human superior colliculus during working memory
Chen, D.; Kragel, P. A.; Wager, T. D.; Wald, L. L.; Bianciardi, M.; Satpute, A. B.; Quigley, K. S.; Barrett, L. F.; Katsumi, Y.; Theriault, J. E.
10.1101/2022.12.06.518975 — neuroscience — Posted on 2022-12-06
3263 A screen for modulation of nucleocapsid protein condensation identifies small molecules with anti-coronavirus activity
Quek, R. T.; Hardy, K. S.; Walker, S. G.; Nguyen, D. T.; de Almeida Magalhaes, T.; Salic, A.; Gopalakrishnan, S. M.; Silver, P. A.; Mitchison, T. J.
10.1101/2022.12.05.519191 — molecular biology — Posted on 2022-12-06
3265 Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection
Hassler, L.; Wysocki, J.; Ahrendsen, J. T.; Ye, M.; Gelarden, I.; Nicolaescu, V.; Tomatsidou, A.; Gula, H.; Cianfarini, C.; Khurram, N.; Kanwar, Y.; Singer, B. D.; Randall, G.; Missiakas, D. M.; Henkin, J.; Batlle, D.
10.1101/2022.12.05.519032 — pathology — Posted on 2022-12-06
3266 Frame Editors for Precise, Template-Free Frameshifting
Nakade, S.; Nakamae, K.; Tang, T.-C.; Yu, D.; Sakuma, T.; Yamamoto, T.; Lu, T. K.
10.1101/2022.12.05.518807 — bioengineering — Posted on 2022-12-06
3267 Evaluation of Zoetis GeneMax Advantage genomic predictions in commercial Bos taurus Angus cattle
Arisman, B. C.; Rowan, T. N.; Thomas, J. M.; Durbin, H. J.; Lamberson, W.; Patterson, D. J.; Decker, J. E.
10.1101/2020.10.23.353144 — genomics — Posted on 2022-12-06
3268 A first-in-class Wiskott-Aldrich syndrome protein (WASp) activator with anti-tumor activity in hematological cancers
Spriano, F.; Sartori, G.; Barnabei, L.; Arribas, A. J.; Guala, M.; Del Amor, A. M.; Tomasso, M. R.; Tarantelli, C.; Cascione, L.; Golino, G.; Riveiro, M. E.; Bortolozzi, R.; Lupia, A.; Paduano, F.; Huguet, S.; Rezai, K.; Margheriti, F.; Ventura, P.; Guarda, G.; Costa, G.; Rocca, R.; Cavalli, A.; Viola, G.; Driessen, C.; Zucca, E.; Stathis, A.; Bornhauser, B.; Alcaro, S.; Trapasso, F.; Cristobal, S.; Padrick, S. B.; Pazzi, N.; Cavalli, F.; Bertoni, F.; Gaudio, E.
10.1101/2022.11.25.517686 — cancer biology — Posted on 2022-12-06
3269 Tethering by Uso1 is dispensable: The Uso1 monomeric globular head domain interacts with SNAREs to maintain viability.
Bravo-Plaza, I.; Tagua, V. G.; Arst, H. N.; Alonso, A.; Pinar, M.; Monterroso, B.; Galindo, A.; Penalva, M. A.
10.1101/2022.11.30.518472 — cell biology — Posted on 2022-12-06
3271 Frame Editors for Precise, Template-Free Frameshifting
Nakade, S.; Nakamae, K.; Tang, T.-C.; Yu, D.; Sakuma, T.; Yamamoto, T.; Lu, T. K.
10.1101/2022.12.05.518807 — bioengineering — Posted on 2022-12-06
3274 Laminarin-triggered defence responses are geographically dependent for natural populations of Solanum chilense
Kahlon, P. S.; Förner, A.; Muser, M.; Oubounyt, M.; Gigl, M.; Hammerl, R.; Baumbach, J.; Hückelhoven, R.; Dawid, C.; Stam, R.
10.1101/2021.06.25.449942 — plant biology — Posted on 2022-12-06
3275 In situ quantification of osmotic pressure within living embryonic tissues
Vian, A.; Pochitaloff, M.; Yen, S.-T.; Kim, S.; Pollock, J.; Liu, Y.; Sletten, E. M.; Campas, O.
10.1101/2022.12.04.519060 — biophysics — Posted on 2022-12-06
3276 Persulfidation of DJ-1 : Mechanism and Consequences
Galardon, E.; Mathas, N.; Padovani, D.; Le Corre, L.; Poncet, G.; Dairou, J.
10.1101/2022.11.09.515774 — biochemistry — Posted on 2022-12-06
3278 The canonical E2Fs together with RETINOBLASTOMA-RELATED are required to establish quiescence during plant development
Gombos, M.; Raynaud, C.; Molnar, E.; Nomoto, Y.; Brik-Chaouche, R.; Takatsuka, H.; Zaki, A.; Bernula, D.; Latrasse, D.; Mineta, K.; Nagy, F.; He, X.; Iwakawa, H.; Oszi, E.; An, J.; Suzuki, T.; Papdi, C.; Bergis, C.; Benhamed, M.; Bogre, L.; Ito, M.; Magyar, Z.
10.1101/2022.12.05.519120 — plant biology — Posted on 2022-12-06
3281 Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands
Fierro, F.; Peri, L.; Huebner, H.; Tabor-Schkade, A.; Waterloo, L.; Loeber, S.; Pfeiffer, T.; Weikert, D.; Dingjan, T.; Margulis, E.; Gmeiner, P.; Niv, M. Y.
10.1101/2022.11.24.517821 — bioinformatics — Posted on 2022-12-06
3282 Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
Teano, G.; Concia, L.; Carron, L.; Wolff, L.; Biocanin, I.; Adamusova, K.; Fojtova, M.; Bourge, M.; Kramdi, A.; Colot, V.; Grossniklaus, U.; Bowler, C.; Baroux, C.; Carbone, A.; Probst, A. V.; Prochazkova Schrumpfova, P.; Fajkus, J.; Amiard, S.; Grob, S.; Bourbousse, C.; Barneche, F.
10.1101/2020.11.28.402172 — molecular biology — Posted on 2022-12-06
3283 Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function
Ghosal, S.; Gebara, E.; Ramos-Fernandez, E.; Chioino, A.; Grosse, J.; Schneider, B. L.; Zorzano, A.; Astori, S.; Sandi, C.
10.1101/2022.10.07.511275 — neuroscience — Posted on 2022-12-06
3284 Behavioral encoding across timescales by region-specificdopamine dynamics
Jorgensen, S. H.; Ejdrup, A. L.; Lycas, M. D.; Posselt, L. P.; Madsen, K. L.; Tian, L.; Dreyer, J. K.; Herborg, F.; Sorensen, A. T.; Gether, U.
10.1101/2022.12.04.519022 — neuroscience — Posted on 2022-12-06
3285 Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers In Vivo
Magoling, B. J. A.; Wu, A. Y.-T.; Chen, Y.-J.; Wong, W. W.-T.; Chuo, S. T.-Y.; Huang, H.-C.; Sung, Y.-C.; Hsieh, H.-T.; Huang, P.; Lee, K.-Z.; Huang, K.-W.; Chen, R.-H.; Chen, Y.; Lai, C. P.
10.1101/2022.09.28.510006 — cancer biology — Posted on 2022-12-06
3288 Elucidation of Amyloid-Beta's Gambit in Oligomerisation:Truncated Aβ fragments of residues Aβ1-23, Aβ1-24 and Aβ1-25 rapidly seed to form SDS-stable, low molecular weight Aβ oligomers that impair synaptic plasticity.
Gil, B.; Rose, J.; Demurtas, D.; Mancini, G.-F.; Sordet-Dessimoz, J.; Sorrentino, V.; Rudinskiy, N.; Frosch, M. P.; Hyman, B. T.; Moniatte, M.; Spires-Jones, T. L.; Herron, C. E.; Schmid, A. W.
10.1101/2022.12.04.519021 — neuroscience — Posted on 2022-12-06
3290 Tissue-Like 3D Standard and Protocols for Microscope Quality Management
Abrams, B.; Pengo, T.; Wee, T. L.; Deagle, R. C.; Vuillemin, N.; Callahan, L. M.; Smith, M. A.; Kubow, K. E.; Girard, A.-M.; Rappoport, J. Z.; Bayles, C. J.; Cameron, L. A.; Cole, R.; Brown, C. M.
10.1101/2022.08.14.503777 — cell biology — Posted on 2022-12-05
3292 Loss of tumor suppressor WWOX accelerates pancreatic cancerdevelopment through promotion of TGFβ/BMP2 signaling
Husanie, H.; Abu-Remaileh, M.; Maroun, K.; Abu-Tair, L.; Safadi, H.; Atlan, K.; Golan, T.; Aqeilan, R. I.
10.1101/2022.03.10.483835 — cancer biology — Posted on 2022-12-05
3293 Male mammalian meiosis and spermiogenesis is critically dependent on the shared functions of the katanins KATNA1 and KATNAL1
Dunleavy, J. E.; Graffeo, M.; Wozniak, K.; O'Connor, A. E.; Merriner, D. J.; Nguyen, J.; Schittenhelm, R. B.; Houston, B. J.; O'Bryan, M.
10.1101/2022.11.11.516072 — cell biology — Posted on 2022-12-05
3294 MADS31 supports female germline development by repressing the post-fertilization program in cereal ovules
Yang, X.; Li, G.; Shi, J.; Wilkinson, L. G.; Aubert, M. K.; Houston, K.; Shirley, N. J.; Colombo, L.; Tucker, M. R.
10.1101/2022.12.05.519106 — plant biology — Posted on 2022-12-05
3297 Universal closed-tube barcoding for monitoring the shark and ray trade in megadiverse conservation hotspots
Prasetyo, A. P.; Cusa, M.; Murray, J.; Agung, F.; Muttaqin, E.; Mariani, S.; McDevitt, A.
10.1101/2022.11.30.518468 — genetics — Posted on 2022-12-05
3298 Deleterious effects of thermal and water stresses on life history and physiology: a case study on woodlouse
DEPEUX, C.; BRANGER, A.; MOULIGNIER, T.; MOREAU, J.; Lemaitre, J.-F.; DECHAUME-MONCHARMONT, F.-X.; LAVERRE, T.; PAULHAC, H.; GAILLARD, J.-M.; BELTRAN-BECH, S.
10.1101/2022.09.26.509512 — evolutionary biology — Posted on 2022-12-05
3299 Spatiotemporal Distribution of Vector Mosquito Species and Areas at Risk for Arbovirus Transmission in Maricopa County, Arizona
Wilke, A. B. B.; Damian, D.; Litvinova, M.; Byrne, T.; Zardini, A.; Poletti, P.; Merler, S.; Mutebi, J.-P.; Townsend, J.; Ajelli, M.
10.1101/2022.07.28.501907 — ecology — Posted on 2022-12-05
3300 Processing of the hepatitis E virus polyprotein can be mediated by a cellular protease
Pierce, D. M.; Buchanan, F. J. T.; Cox, A.; Abualsaud, K. M.; Ward, J. C.; Harris, M.; Stonehouse, N. J.; Herod, M. R.
10.1101/2022.12.05.519104 — microbiology — Posted on 2022-12-05
3302 Non-invasive multi-channel electrophysiology of the human spinal cord - assessing somatosensory processing from periphery to cortex
Nierula, B.; Stephani, T.; Kaptan, M.; Mouraux, A.; Maess, B.; Villringer, A.; Curio, G.; Nikulin, V. V.; Eippert, F.
10.1101/2022.12.05.519148 — neuroscience — Posted on 2022-12-05
3303 Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2
Pastor-Alonso, O.; Syeda Zahra, A.; Kaske, B.; Garcia-Moreno, F.; Tetzlaff, F.; Bockelmann, E.; Grunwald, V.; Martin-Suarez, S.; Riecken, K.; Witte, O. W.; Encinas, J. M.; Urbach, A.
10.1101/2022.12.05.518892 — neuroscience — Posted on 2022-12-05
3304 Robust online multiband drift estimation in electrophysiology data
Windolf, C.; Paulk, A. C.; Kfir, Y.; Trautmann, E.; Garcia, S.; Meszena, D.; Munoz, W.; Caprara, I.; Jamali, M.; Boussard, J. C.; Williams, Z. M.; Cash, S. S.; Paninski, L.; Varol, E.
10.1101/2022.12.04.519043 — neuroscience — Posted on 2022-12-05
3305 Dynamin A as a one-component division machinery for synthetic cells
De Franceschi, N.; Barth, R.; Meindlhumer, S.; Fragasso, A.; Dekker, C.
10.1101/2022.12.05.519112 — synthetic biology — Posted on 2022-12-05
3306 Synergic homology directed recombination by PRDM9 meiotic factor
Sanvicente, M.; Gonzalez-Bermudez, L.; Batlle, L.; Acosta, S.; Guell, M.; Sanchez-Mejias, A.
10.1101/2022.12.05.519167 — synthetic biology — Posted on 2022-12-05
3309 Deep Learning Allows Assessment of Risk of Metastatic Relapse from Invasive Breast Cancer Histological Slides
Garberis, I.; Gaury, V.; Saillard, C.; Drubay, D.; Elgui, K.; Schmauch, B.; Jaeger, A.; Herpin, L.; Linhart, J.; Sapateiro, M.; Bernigole, F.; Kamoun, A.; Bendjebbar, E.; de Lavergne, A.; Dubois, R.; Auffret, M.; Guillou, L.; Bousaid, I.; Azoulay, M.; Lemonnier, J.; Sefta, M.; Jacquet, A.; Sarrazin, A.; Reboud, J.-F.; Brulport, F.; Dachary, J.; Pistilli, B.; Delaloge, S.; Courtiol, P.; Andre, F.; Aubert, V.; Lacroix-Triki, M.
10.1101/2022.11.28.518158 — pathology — Posted on 2022-12-05
3310 Mechanisms of HIV-1 Integrase Resistance to Dolutegravir and Potent Inhibition of Drug Resistant Variants
Li, M.; Passos, D.; Shan, Z.; Smith, S. J.; Sun, Q.; Biswas, A.; Choudhuri, I.; Strutzenberg, T.; Haldane, A.; Deng, N.; Li, Z.; Zhao, X.-Z.; Burke, T. R.; Levy, R. M.; Hughes, S. H.; Craigie, R.; Lyumkis, D.
10.1101/2022.12.04.519057 — biophysics — Posted on 2022-12-05
3314 Pre-epidemic evolution of the USA300 clade and a molecular key for classification
Bianco, C.; Moustafa, A.; OBrien, K.; Martin, M.; Read, T.; Kreiswirth, B. N.; Planet, P.
10.1101/2022.12.05.519169 — genomics — Posted on 2022-12-05
3315 Aging-associated changes in transcriptional elongation influence metazoan longevity.
Debes, C.; Papadakis, A.; Grönke, S.; Karaley, O.; Tain, L.; Nakamura, S.; Hahn, O.; Weigelt, C.; Josipovic, N.; Zirkel, A.; Brusius, I.; Sofiadis, K.; Lamprousi, M.; Lu, Y.-X.; Huang, W.; Esmaillie, R.; Kubacki, T.; Späth, M.; Schermer, B.; Benzing, T.; Müller, R.-U.; Antebi, A.; Partridge, L.; Papantonis, A.; Beyer, A.
10.1101/719864 — genomics — Posted on 2022-12-05
3317 Sequence-to-expression approach to identify etiological non-coding DNA variations in P53 and cMYC-driven diseases
Kin, K.; Bhogale, S.; Zhu, L.; Thomas, D.; Bertol, J.; Zheng, W. J.; Sinha, S.; Fakhouri, W. D.
10.1101/2022.12.05.519089 — genetics — Posted on 2022-12-05
3318 REC protein family expansion by the emergence of a new signaling pathways
Garber, M. E.; Frank, V.; Kazakov, A. E.; Zhang, H.; Incha, M. R.; Keasling, J. D.; Rajeev, L.; Mukhopadhyay, A.
10.1101/2020.09.30.321588 — evolutionary biology — Posted on 2022-12-05
3323 Dissecting the cell of origin of aberrant SALL4 expression in myelodysplastic syndrome
Tatetsu, H.; Watanabe, M.; Liu, J.; Tokunaga, K.; Iwanaga, E.; Komohara, Y.; Thrash, E.; Matsuoka, M.; Tenen, D. G.; Chai, L.
10.1101/2022.12.05.518121 — cell biology — Posted on 2022-12-05
3324 Panton-Valentine leukocidin-induced neutrophil extracellular traps lack antimicrobial activity and are readily induced in patients with recurrent PVL+-Staphylococcus aureus infections
Jhelum, H.; Cerina, D.; Harbort, C. J.; Lindner, A.; Hanitsch, L. G.; Leistner, R.; Schröder, J.-T.; von Bernuth, H.; Stegemann, M. S.; Schürmann, M.; Zychlinsky, A.; Krüger, R.; Marsman, G.
10.1101/2021.11.26.470012 — immunology — Posted on 2022-12-05
3326 Resilient CD8+ T cells maintain a high cytotoxic capacity by balancing ROS via ME1 upregulation
Gicobi, J. K.; Mao, Z.; DeFranco, G.; Li, Y.; Liu, X.; Hirdler, J. B.; Vianzon, V. V.; Dellacecca, E. R.; Hsu, M. A.; Barham, W.; Kim, Y. H.; Feven, A.; Harmsen, W. S.; Yan, Y.; Dronca, R. S.; Zhu, M.; Markovic, S.; Mansfield, A. S.; Lin, Y.; Wu, X.; Owen, D.; Grams, M. P.; Orme, J. J.; Lucien, F.; Zeng, H.; Park, S. S.; Dong, H.
10.1101/2022.11.25.517988 — immunology — Posted on 2022-12-05
3329 Ketamines rapid antidepressant effects are mediated by Ca2+ - permeable AMPA receptors in the hippocampus
Zaytseva, A.; Bouckova, E.; Wiles, M. J.; Wustrau, M. H.; Schmidt, I. G.; Mendez-Vazquez, H.; Khatri, L.; Kim, S.
10.1101/2022.12.05.519102 — neuroscience — Posted on 2022-12-05
3330 Behavioral encoding across timescales by region-specificdopamine dynamics
Jorgensen, S. H.; Ejdrup, A. L.; Lycas, M. D.; Posselt, L. P.; Madsen, K. L.; Tian, L.; Dreyer, J. K.; Herborg, F.; Sorensen, A. T.; Gether, U.
10.1101/2022.12.04.519022 — neuroscience — Posted on 2022-12-05
3331 The vestibular calyceal junction is dismantled in response to diverse injuring stimuli in rats and humans
Maroto, A. F.; Borrajo, M.; Prades, S.; Callejo, A.; Amilibia, E.; Perez-Grau, M.; Roca-Ribas, F.; Castellanos, E.; Barrallo-Gimeno, A.; Llorens, J.
10.1101/2022.05.17.492294 — neuroscience — Posted on 2022-12-05
3332 Sex-specific microglial responses to glucocerebrosidase inhibition: relevance to GBA1-linked Parkinson disease
Ciana, P.; Brunialti, E.; Villa, A.; Toffoli, M.; Lucas Del Pozo, S.; Rizzi, N.; Meda, C.; Maggi, A. C.; Schapira, A. H. V.
10.1101/2022.12.05.519143 — neuroscience — Posted on 2022-12-05
3333 Stimulus information guides the emergence of behavior related signals in primary somatosensory cortex during learning
Panniello, M.; Gillon, C. J.; Maffulli, R.; Celotto, M.; Panzeri, S.; Richards, B. A.; Kohl, M. M.
10.1101/2022.12.04.518156 — neuroscience — Posted on 2022-12-05
3334 Minimal exposures reveal visual processing priorities
Lanfranco, R. C.; Canales-Johnson, A.; Rabagliati, H.; Cleeremans, A.; Carmel, D.
10.1101/2021.10.06.462913 — neuroscience — Posted on 2022-12-05
3340 Electrogenetic signaling and information propagation for controlling microbial consortia via programmed lysis
VanArsdale, E.; Navid, A.; Chu, M. J.; Halvorsen, T. M.; Payne, G. F.; Jiao, Y.; Bentley, W. E.; Yung, M. C.
10.1101/2022.12.05.519192 — synthetic biology — Posted on 2022-12-05
3342 Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma
Obacz, J.; Nibhani, R.; Adams, T. S.; Schupp, J. C.; Valer, J. A.; Veale, N.; Aresu, G.; Coonar, A. S.; Peryt, A.; Biffi, G.; Kaminski, N.; Francies, H. E.; Rassl, D.; Garnett, M.; Rintoul, R. C.; Marciniak, S. J.
10.1101/2022.12.03.518966 — cancer biology — Posted on 2022-12-05
3343 The 3D chromatin landscape of rhabdomyosarcoma
Wang, M.; Sreenivas, P.; Sunkel, B. D.; Wang, L. D.; Ignatius, M. S.; Stanton, B.
10.1101/2022.12.05.519166 — cancer biology — Posted on 2022-12-05
3344 Syngeneic model of carcinogen-induced tumor mimics basal/squamous, stromal-rich, and neuroendocrine molecular and immunological features of muscle-invasive bladder cancer
Shah, S. D.; Gillard, B. M.; Wrobel, M. M.; Karasik, E.; Moser, M. T.; Mastri, M.; Sule, N.; Brackett, C. M.; HUSS, W. J.; Foster, B. A.
10.1101/2022.12.03.518865 — cancer biology — Posted on 2022-12-05
3346 CryoEM Structures of the Human HIV-1 Restriction Factor SERINC3 and Function as a Lipid Transporter
Leonhardt, S. A.; Purdy, M. D.; Grover, J. R.; Yang, Z.; Poulos, S.; McIntire, W. E.; Tatham, E. A.; Erramilli, S.; Nosol, K.; Lai, K. K.; Ding, S.; Lu, M.; Uchil, P. D.; Finzi, A. D.; Rein, A.; Kossiakoff, A. A.; Mothes, W.; Yeager, M.
10.1101/2022.07.06.498924 — biophysics — Posted on 2022-12-05
3348 A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone
Wang, Z.; Cheong, S.; Pereira, J. H.; Kim, J.; DeGiovanni, A.; Guo, Y.; Lan, G.; Barcelos, C. A.; Haushalter, R.; Lee, T. S.; Adams, P. D.; Keasling, J. D.
10.1101/2022.12.04.519061 — bioengineering — Posted on 2022-12-05
3349 Frame Editors for Precise, Template-Free Frameshifting
Nakade, S.; Nakamae, K.; Tang, T.-C.; Yu, D.; Sakuma, T.; Yamamoto, T.; Lu, T. K.
10.1101/2022.12.05.518807 — bioengineering — Posted on 2022-12-05
3351 Illuminating the mechanism and allosteric behavior of NanoLuc luciferase
Nemergut, M.; Pluskal, D.; Horackova, J.; Sustrova, T.; Tulis, J.; Baatallah, R.; Gagnot, G.; Novakova, V.; Majerova, M.; Marques, S. M.; Toul, M.; Damborsky, J.; Bednar, D.; Prokop, Z.; Janin, Y. L.; Marek, M.
10.1101/2022.12.05.519101 — biochemistry — Posted on 2022-12-05
3352 Nitrate Assimilation Underlying Kleptoplasty
Maruyama, M.; Kagamoto, T.; Matsumoto, Y.; Onuma, R.; Miyagishima, S.-y.; Tanifuji, G.; Nakazawa, M.; Kashiyama, Y.
10.1101/2022.12.04.518691 — biochemistry — Posted on 2022-12-05
3355 Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes
Schwab, K.; Coronel, L.; Riege, K.; Sacramento, E. K.; Rahnis, N.; Haeckes, D.; Cirri, E.; Groth, M.; Hoffman, S.; Fischer, M.
10.1101/2022.12.05.519097 — genomics — Posted on 2022-12-05
3356 Mutated cells mediate distinct inflammatory responses in clonal hematopoiesis
Heimlich, J. B.; Bhat, P.; Parker, A. C.; Jenkins, M. T.; Vlasschaert, C.; Ulloa, J.; Potts, C. R.; Olson, S.; Silver, A. J.; Ahmad, A.; Sharber, B.; Brown, D.; Hu, N.; van Galen, P.; Savona, M. R.; Bick, A. G.; Ferrell, P. B.
10.1101/2022.12.01.518580 — genetics — Posted on 2022-12-05
3357 Cis-regulatory evolution of the potassium channel gene kcnj13 during pigment pattern diversification in Danio fish
Podobnik, M.; Singh, A. P.; Fu, Z.; Dooley, C. M.; Frohnhoefer, H. G.; Firlej, M.; Elhabashy, H.; Weyand, S.; Weir, J.; Lu, J.; Nuesslein-Volhard, C.; Irion, U.
10.1101/2022.12.05.519077 — evolutionary biology — Posted on 2022-12-05
3359 Like mother, like daughter? Phenotypic plasticity, environmental covariation, and heritability of size in a parthenogenetic wasp
Tovar, A.; Monahan, S.; Kristan, A.; Welch, W.; Dettmers, R.; Arce, C.; Buck, T.; Ruben, M.; Rothenberg, A.; Saisho, R.; Cartmill, R.; Skaggs, T.; Reyes, R.; Lee, M.; Obrycki, J. J.; Kristan, W.; Sethuraman, A.
10.1101/2022.12.02.518902 — evolutionary biology — Posted on 2022-12-05
3361 Common predators and factors influencing their abundance in Anopheles funestus aquatic habitats in rural south-eastern Tanzania
Mahenge, H. H.; Muyaga, L. L.; Nkya, J. D.; Kifungo, K. S.; Kahamba, N. F.; Ngowo, H. S.; Kaindoa, E. W.
10.1101/2022.12.03.518970 — ecology — Posted on 2022-12-05
3362 Conserving evolutionary history to safeguard our future: incorporating the Tree of Life into biodiversity policy
Gumbs, R.; Chaudhary, A.; Daru, B. H.; Faith, D. P.; Forest, F.; Gray, C. L.; Kowalska, A.; Lee, W.-S.; Pellens, R.; Pipins, S.; Pollock, L. J.; Rosindell, J.; Scherson, R. A.; Owen, N. R.
10.1101/2021.03.03.433783 — ecology — Posted on 2022-12-05
3366 The unique structure and replication mode of the replication system of Klebsiella pneumoniae plasmid pIGMS31
Wawrzyniak, P.; Baranska, S.; Hernandez, P.; Dylewski, M.; Cecuda-Adamczewska, V.; Stypinski, Łukasz; Kabaj, P.; Goscik, A.; Bartosik, D.
10.1101/2022.12.05.519187 — molecular biology — Posted on 2022-12-05
3367 Metagenomic insights for antimicrobial resistance surveillance in soils with different land uses in Brazil
Ordine, J. V. W.; de Souza, G. M.; Tamasco, G.; Virgilio, S.; Fernandes, A. F. T.; Silva-Rocha, R.; Guazzaroni, M.-E.
10.1101/2022.12.05.519117 — microbiology — Posted on 2022-12-05
3369 Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR
Obana, N.; Takada, H.; Crowe-McAuliffe, C.; Iwamoto, M.; Egorov, A. A.; Wu, K. J. Y.; Murina, V.; Paternoga, H.; Tresco, B. I. C.; Nomura, N.; Myers, A. G.; Atkinson, G. C.; Wilson, D. N.; Hauryliuk, V.
10.1101/2022.12.05.519065 — microbiology — Posted on 2022-12-05
3371 Isolation and genome characterization of Lloviu virus from Italian Schreibers bent-winged bats
Toth, G. E.; Hume, A. J.; Suder, E. L.; Zeghbib, S.; Abraham, A.; Lanszki, Z.; Varga, Z.; Tauber, Z.; Foldes, F.; Zana, B.; Scaravelli, D.; Scicluna, M. T.; Pereswiet-Soltan, A.; Gorfol, T.; Terregino, C.; De Benedictis, P.; Garcia-Dorival, I.; Alonso, C.; Jakab, F.; Muhlberger, E.; Leopardi, S.; Kemenesi, G.
10.1101/2022.12.05.519067 — microbiology — Posted on 2022-12-05
3372 Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy
Ferrian, S.; McCaffrey, E. F.; Saito, T.; Cao, A.; Greenwald, N. F.; Nicolls, M. R.; Bruce, T.; Zamanian, R. T.; Del Rosario, P. A.; Rabinovitch, M.; Angelo, M.
10.1101/2022.12.03.518033 — immunology — Posted on 2022-12-05
3374 Spatial organization of the mouse retina at single cell resolution
Choi, J.; Li, J.; Ferdous, S.; Liang, Q.; Moffitt, J. R.; Chen, R.
10.1101/2022.12.04.518972 — neuroscience — Posted on 2022-12-05
3375 Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of persistent pain
Marty-Lombardi, S.; Lu, S.; Ambroziak, W.; Wende, H.; Schrenk-Siemens, K.; DePaoli-Roach, A. A.; Hagenston, A. M.; Tappe-Theodor, A.; Simonetti, M.; Kuner, R.; Fleming, T.; Siemens, J.
10.1101/2022.12.03.518519 — neuroscience — Posted on 2022-12-05
3376 IKBKB reduces huntingtin aggregation by phosphorylating Serine 13 via a non-canonical IKK pathway
Cariulo, C.; Martufi, P.; Verani, M.; Toledo, L. S.; Lee, R.; Dominguez, C.; Petricca, L.; Caricasole, A.
10.1101/2022.12.05.519070 — neuroscience — Posted on 2022-12-05
3377 Brain activation by a VR-based motor imagery andobservation task: An fMRI study
Nunes, J. D.; Vourvopoulos, A.; Blanco-Mora, D. A.; Jorge, C.; Fernandes, J.-C.; i Badia, S. B.; Figueiredo, P.
10.1101/2022.12.05.519096 — neuroscience — Posted on 2022-12-05
3378 Spontaneous and multifaceted ATP release from astrocytes at the scale of hundreds of synapses
Hatashita, Y.; Wu, Z.; Fujita, H.; Kumamoto, T.; Livet, J.; Li, Y.; Tanifuji, M.; Inoue, T.
10.1101/2022.12.05.519082 — neuroscience — Posted on 2022-12-05
3379 IFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS-associated Amyotrophic Lateral Sclerosis
Assoni, A.; Guerrero, E. N.; Wardenaar, R.; Oliveira, D.; Bakker, P. L.; Melechco Carvalho, V.; Okamoto, O. K.; Zatz, M.; Foijer, F.
10.1101/2022.12.05.519150 — neuroscience — Posted on 2022-12-05
3380 Molecular dynamics analysis of Superoxide Dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression
Kalia, M.; Miotto, M.; Ness, D.; Opie-Martin, S.; Spargo, T. P.; Di Rienzo, L.; Biagini, T.; Petrizzelli, F.; Al-Khleifat, A.; Kabiljo, R.; Topp, S.; Mayl, K.; Fogh, I.; Mehta, P. R.; Williams, K. L.; Jockel-Balsarotti, J.; Bali, T.; Self, W.; Henden, L.; Nicholson, G. A.; Ticozzi, N.; McKenna-Yasek, D.; Tang, L.; Shaw, P.; Chio, A.; Ludolph, A.; Weishaupt, J. H.; Landers, J. E.; Glass, J. D.; Mora, J. S.; Robberecht, W.; Van Damme, P.; McLaughlin, R.; Hardiman, O.; van den Berg, L. H.; Veldink, J. H.; Corcia, P.; Stevic, Z.; Siddique, N.; Ratti, A.; Silani, V.; Blair, I. P.; Fan, D.-s.; Essel
10.1101/2022.12.05.519128 — neuroscience — Posted on 2022-12-05
3385 iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory Phenotype
Sullivan, M. A.; Lane, S. D.; Ball, S. R.; Sunde, M.; Neely, G. G.; Moreno, C.; Werry, E. L.; Kassiou, M.
10.1101/2022.12.05.518134 — neuroscience — Posted on 2022-12-05
3386 Elucidation of Amyloid-Beta's Gambit in Oligomerisation:Truncated Aβ fragments of residues Aβ1-23, Aβ1-24 and Aβ1-25 rapidly seed to form SDS-stable, low molecular weight Aβ oligomers that impair synaptic plasticity.
Gil, B.; Rose, J.; Demurtas, D.; Mancini, G.-F.; Sordet-Dessimoz, J.; Sorrentino, V.; Rudinskiy, N.; Frosh, M. P.; Hyman, B. T.; Moniatte, M.; Spires-Jones, T. L.; Herron, C. E.; Schmid, A. W.
10.1101/2022.12.04.519021 — neuroscience — Posted on 2022-12-05
3389 Growth Signaling Autonomy in Circulating Tumor Cells Aids Metastatic Seeding
Sinha, S.; Farfel, A.; Luker, K. E.; Sahoo, D.; Parker, B. A.; Yeung, K.; Luker, G. D.; Ghosh, P.
10.1101/2022.12.02.518910 — cancer biology — Posted on 2022-12-05
3392 The PRALINE database: Protein and Rna humAn singLe nucleotIde variaNts in condEnsates
Vandelli, A.; Arnal Segura, M.; Monti, M.; Fiorentino, J.; Broglia, L.; Colantoni, A.; Sanchez de Groot, N.; Torrent Burgas, M.; Armaos, A.; Tartaglia, G. G.
10.1101/2022.12.03.518982 — bioinformatics — Posted on 2022-12-05
3393 Sharing Massive Biomedical Data at Magnitudes Lower Bandwidth Using Implicit Neural Function
Yang, R.; Xiao, T.; Cheng, Y.; Li, A.; Qu, J.; Liang, R.; Bao, S.; Wang, X.; Suo, J.; Luo, Q.; Dai, Q.
10.1101/2022.12.03.518948 — bioinformatics — Posted on 2022-12-05
3394 Inducible non-human primate models of retinal degeneration for testing end stage therapies and understanding disease mechanisms
Ail, D.; Nava, D.; Hwang, I. P.; Brazhnikova, E.; Jaillard, C. N.; Dentel, A.; Joffrois, C.; Rousseau, L.; Degardin, J.; Bertin, S.; Sahel, J. A.; Goureau, O.; Picaud, S.; Dalkara, D.
10.1101/2022.12.03.518955 — bioengineering — Posted on 2022-12-05
3395 Ascending and Descending Aortic ECM Hydrogels for Modeling Aortic Wall Biology
Lee, Y. C.; Richards, T. D.; Fantini, D. A.; Kaczorowski, D. J.; Brown, B. N.; Phillippi, J. A.
10.1101/2022.12.03.518904 — bioengineering — Posted on 2022-12-05
3397 Drosophilid cuticle pigmentation impacts body temperature
Freoa, L.; Chevin, L.-M.; Christol, P.; Meleard, S.; Rera, M.; Veber, A.; Gibert, J.-M.
10.1101/2022.12.03.518031 — evolutionary biology — Posted on 2022-12-05
3398 New high-resolution maps show that rubber causes significant deforestation
Wang, Y.; Hollingsworth, P. M.; Zhai, D.; West, C. D.; Green, J.; Chen, H.; Hurni, K.; Su, Y.; Warren-Thomas, E.; Xu, J.; Ahrends, A.
10.1101/2022.12.03.518959 — ecology — Posted on 2022-12-05
3403 Breathe Easy, an automated respiratory data pipeline for waveform characteristic analysis
Lusk, S.; Ward, C. S.; Chang, A.; Twitchell-Heyne, A.; Fattig, S.; Allen, G.; Jankowsky, J.; Ray, R.
10.1101/2022.12.02.518741 — physiology — Posted on 2022-12-05
3404 Cyclic lipopeptides as membrane fusion inhibitors against SARS-CoV-2: new tricks for old dogs
Shekunov, E. V.; Zlodeeva, P. Z.; Efimova, S. S.; Muryleva, A. A.; Zarubaev, V. V.; Slita, A. V.; Ostroumova, O. S.
10.1101/2022.12.05.519140 — molecular biology — Posted on 2022-12-05
3405 High resolution cryo-EM structures of two potently SARS-CoV-2 neutralizing monoclonal antibodies of same donor origin that vary in neutralizing Omicron variants
Rencilin, C. F.; Ansari, M. Y.; Chatterjee, A.; Deshpande, S.; Mukherjee, S.; Singh, R.; Jayatheertha, S.; Reddy, P. M.; Das, P.; Hingankar, N.; Rathore, D.; Varadarajan, R.; Bhattacharya, J.; Dutta, S.
10.1101/2022.12.03.518949 — biophysics — Posted on 2022-12-05
3406 Performance of computational algorithms to deconvolve heterogeneous bulk tumor tissue depends on experimental factors
Hippen, A. A.; Omran, D. K.; Weber, L. M.; Jung, E.; Drapkin, R.; Doherty, J. A.; Hicks, S. C.; Greene, C. S.
10.1101/2022.12.04.519045 — bioinformatics — Posted on 2022-12-05
3407 DiffDomain enables identification of structurally reorganized topologically associating domains
Hua, D.; Gu, M.; Zhang, X.; Du, Y.; Xie, H.; Qi, L.; Du, X.; Bai, Z.; Zhu, X.; Tian, D.
10.1101/2022.12.05.519135 — bioinformatics — Posted on 2022-12-05
3408 Covidscope: An atlas-scale COVID-19 resource for single-cell meta analysis at sample and cell levels
Yin, D.; Cao, Y.; Chen, J.; Mak, C. L. Y.; Yu, K. H. O.; Lin, Y.; Ho, J. W. K.; Yang, J. Y. H.
10.1101/2022.12.03.518997 — bioinformatics — Posted on 2022-12-05
3409 Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane
Shi, W.; Cai, Y.; Zhu, H.; Peng, H.; Voyer, J.; Rits-Volloch, S.; Cao, H.; Mayer, M. L.; Song, K.; Xu, C.; Lu, J.; Zhang, J.; Chen, B.
10.1101/2022.12.05.519151 — biochemistry — Posted on 2022-12-05
3410 Convergent evolution of the SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant
Ito, J.; Suzuki, R.; Uriu, K.; Itakura, Y.; Zahradnik, J.; Deguchi, S.; Wang, L.; Lytras, S.; Tamura, T.; Kida, I.; Nasser, H.; Shofa, M.; Begum, M. M.; Tsuda, M.; Oda, Y.; Fujita, S.; Yoshimatsu, K.; Ito, H.; Nao, N.; Asakura, H.; Nagashima, M.; Sadamasu, K.; Yoshimura, K.; Yamamoto, Y.; Nagamoto, T.; Schreiber, G.; The Genotype to Phenotype Japan (G2P-Japan) Consortium, ; Saito, A.; Matsuno, K.; Takayama, K.; Tanaka, S.; Fukuhara, T.; Ikeda, T.; Sato, K.
10.1101/2022.12.05.519085 — microbiology — Posted on 2022-12-05
3413 Bioinformatics techniques for efficient structure prediction of SARS-CoV-2 protein ORF7a via structure prediction approaches
Kazmi, A.; Kazim, M.; Aslam, F.; Kazmi, S. M.-u.-H.; Wahab, A.; Mikhlef, R. M.; Khizar, C.; Kazmi, A.; Wazir, N. U.; Mainali, R. P.
10.1101/2022.12.03.518956 — microbiology — Posted on 2022-12-05
3416 A Physcomitrella PIN protein acts in spermatogenesis and sporophyte retention
Lueth, V. M.; Rempfer, C.; van Gessel, N.; Herzog, O.; Hanser, M.; Braun, M.; Decker, E. L.; Reski, R.
10.1101/2022.07.05.498815 — plant biology — Posted on 2022-12-05
3422 COVFlow: virus phylodynamics analyses from selected SARS-CoV-2 sequences
Danesh, G.; Boennec, C.; Verdurme, L.; Roussel, M.; Trombert, S.; Visseaux, B.; Haim-Boukobza, S.; Alizon, S.
10.1101/2022.06.17.496544 — bioinformatics — Posted on 2022-12-05
3424 Discovery and biosynthetic assessment of Streptomyces ortus sp nov. isolated from a deep-sea sponge
Williams, S. E.; Back, C. R.; Best, E.; Mantell, J.; Stach, J. E. M.; Williams, T. A.; Race, P. R.; Curnow, P.
10.1101/2022.11.21.517041 — genomics — Posted on 2022-12-05
3427 Metabolomic comparison using Streptomyces spp. as a factory of secondary metabolites
Flores Clavo, R.; Kelyene Pereira, A.; Ruiz Quinones, N.; Henrique Costa, J.; Pacheco Fill, T.; Fantinatti Garboggini, F.
10.1101/2022.12.01.518800 — molecular biology — Posted on 2022-12-05
3428 Targeted chromosomal barcoding establishes direct genotype-phenotype associations for antibiotic resistance in Mycobacterium abscessus
Gonzalo-Asensio, J.; Calvet-Seral, J.; Crespo-Yuste, E.; Mathys, V.; Rodriguez-Villalobos, H.; Ceyssens, P.-J.; Martin, A.
10.1101/2022.12.01.518803 — microbiology — Posted on 2022-12-05
3429 A non-canonical sensing pathway mediates Plasmodium adaptation to AA deficiency
Marreiros, I. M.; Marques, S.; Mastrodomenico, V.; Mounce, B.; Harris, C. T.; Kafsack, B. F.; Billker, O.; Zuzarte-Luis, V.; Mota, M. M.
10.1101/2022.12.01.518651 — microbiology — Posted on 2022-12-05
3434 Biased activation of the receptor tyrosine kinase HER2
Catapano, C.; Rahm, J. V.; Omer, M.; Teodori, L.; Kjems, J.; Dietz, M. S.; Heilemann, M.
10.1101/2022.12.04.519064 — biophysics — Posted on 2022-12-05
3435 Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase
Whinn, K. S.; Xu, Z.-Q.; Jergic, S.; Sharma, N.; Spenkelink, L. M.; Dixon, N. E.; van Oijen, A. M.; Ghodke, H.
10.1101/2022.12.04.519054 — biochemistry — Posted on 2022-12-05
3436 The adherens junction proteins α-catenin, vinculin and VASP cooperate to promote actin assembly
Said, R.; Wang, H.; Pernier, J.; Narassimprakash, H.; Romero, S.; Gautreau, A. M.; Mege, R.-M.; Le Clainche, C.
10.1101/2022.12.04.518837 — biochemistry — Posted on 2022-12-05
3437 Characterisation of neonatal Staphylococcus capitis NRCS-A isolates compared with non NRCS-A Staphylococcus capitis from neonates and adults.
Felgate, H. M.; Sethi, D.; Faust, K.; Kiy, C.; Härtel, C.; Rupp, J.; Clifford, R.; Dean, R.; Tremlett, C.; Wain, J.; Langridge, G.; Clarke, P.; Page, A. J.; Webber, M. A.
10.1101/2022.12.02.518718 — genomics — Posted on 2022-12-05
3438 Is apparent digestibility associated with residual feed intake and enteric methane emission in Nellore cattle?
Gianvecchio, S. B.; Sakamoto, L. S.; Souza, L. L.; Benfica, L. F.; Marcatto, J. d. O. S.; de Paula, E. M.; Canesin, R. C.; Cyrillo, J. d. S. G.; Albuquerque, L. G.; Mercadante, M. E. Z.
10.1101/2022.12.01.518681 — genetics — Posted on 2022-12-05
3439 Invasive terrestrial invertebrate detection in water and soil using a targeted eDNA approach
Villacorta-Rath, C.; Lach, L.; Andrade-Rodriguez, N.; Burrows, D.; Gleeson, D.; Trujillo-Gonzalez, A.
10.1101/2022.11.29.518289 — genetics — Posted on 2022-12-05
3444 Hexokinase 2 localizes to the nucleus in response to glucose limitation but does not regulate gene expression
Lesko, M. A.; Chandrashekarappa, D. G.; Jordahl, E. M.; Oppenheimer, K. G.; Bowman, R. W.; Shang, C.; Durrant, J.; Schmidt, M. C.; O'Donnell, A. F.
10.1101/2022.11.30.518474 — cell biology — Posted on 2022-12-05
3445 GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program
Lewis, M.; Terre, B.; Knobel, P. A.; Cheng, T.; Lu, H.; Attolini, C. S.; Smak, J.; Coyaud, E.; Garcia-Cao, I.; Querol, J.; Gil-Gomez, G.; Piergiovanni, G.; Costanzo, V.; Peiro, S.; Raught, B.; Zhao, H.; Salvatella, X.; Roy, S.; Mahjoub, M.; Stracker, T. H.
10.1101/2022.12.02.518887 — cell biology — Posted on 2022-12-05
3446 Tethering by Uso1 is dispensable: The Uso1 monomeric globular head domain interacts with SNAREs to maintain viability.
Bravo-Plaza, I.; Tagua, V. G.; Arst, H. N.; Alonso, A.; Pinar, M.; Monterroso, B.; Galindo, A.; Penalva, M. A.
10.1101/2022.11.30.518472 — cell biology — Posted on 2022-12-05
3447 The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions
Fan, Z.; Ardicoglu, R.; Batavia, A.; Rust, R.; von Ziegler, L.; Waag, R.; Zhang, J.; Desgeorges, T.; Sturman, O.; Dang, H.; Weber, R.; Moor, A. E.; Schwab, M. E.; Germain, P.-L.; Bohacek, J.; De Bock, K.
10.1101/2022.12.02.518829 — cell biology — Posted on 2022-12-05
3452 Self-organization, quality control, and preclinical studies of human iPSC-derived retinal sheets for tissue-transplantation therapy
Watari, K.; Yamasaki, S.; Tu, H.-Y.; Shikamura, M.; Kamei, T.; Adachi, H.; Tochitani, T.; Kita, Y.; Nakamura, A.; Ueyama, K.; Ono, K.; Morinaga, C.; Matsuyama, T.; Sho, J.; Nakamura, M.; Fujiwara, M.; Hori, Y.; Tanabe, A.; Hirai, R.; Terai, O.; Ohno, O.; Ohara, H.; Hayama, T.; Ikeda, A.; Nukaya, D.; Matsushita, K.; Takahashi, M.; Kishino, A.; Kimura, T.; Kawamata, S.; Mandai, M.; Kuwahara, A.
10.1101/2022.02.18.480968 — neuroscience — Posted on 2022-12-04
3454 Entropic control of the free energy landscape of an archetypal biomolecular machine
Ray, K. K.; Kinz-Thompson, C. D.; Fei, J.; Wang, B.; Lin, Q.; Gonzalez, R. L.
10.1101/2022.10.03.510626 — biophysics — Posted on 2022-12-04
3455 Point-of-care peptide hormone production enabled by cell-free protein synthesis
DeWinter, M. A.; Thames, A. H.; Guerrero, L.; Kightlinger, W. K.; Karim, A. S.; Jewett, M. C.
10.1101/2022.12.03.518932 — synthetic biology — Posted on 2022-12-04
3457 Evolutionary trajectory of organelle-derived nuclear DNAs in the Triticum/Aegilops complex species
Zhang, Z.; Zhao, J.; Li, J.; Yao, J.; Wang, B.; Ma, Y.; Li, N.; Wang, T.; Wang, H.; Liu, B.; Gong, L.
10.1101/2022.12.04.519011 — genomics — Posted on 2022-12-04
3460 Accurate detection and identification of insects from camera trap images with deep learning
Bjerge, K.; Alison, J.; Dyrmann, M.; Frigaard, C. E.; Mann, H. M. R.; Hoye, T. T.
10.1101/2022.10.25.513484 — ecology — Posted on 2022-12-04
3462 Nanoscaled discovery of a shunt rifamycin from Salinispora arenicola using a three-colour GFP-tagged Staphylococcus aureus macrophage infection assay.
Pham, N. T.; Alves, J.; Sargison, F. A.; Cullum, R.; Wildenhain, J.; Fenical, W.; Butler, M. S.; Mead, D.; Duggan, B. M.; Fitzgerald, J. R.; La Clair, J. J.; Auer, M.
10.1101/2022.12.04.519019 — cell biology — Posted on 2022-12-04
3463 Salmonella actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner
Inpanathan, S.; Ospina-Escobar, E.; Cho, Y. H.; Porco, N.; Choy, C. H.; McPhee, J. B.; Botelho, R. J.
10.1101/2022.12.03.518968 — cell biology — Posted on 2022-12-04
3464 Circular RNA circPLOD2 regulates pericyte function by targeting the transcription factor KLF4
Glaser, S. F.; Brezski, A.; Baumgarten, N.; Klangwart, M.; Heumueller, A. W.; Kumar Maji, R.; Leisegang, M. S.; Guenther, S.; Zehendner, C. M.; John, D.; Schulz, M. H.; Zarnack, K.; Dimmeler, S.
10.1101/2022.12.04.519017 — molecular biology — Posted on 2022-12-04
3467 Novel Complete Methanogenic Pathways in Longitudinal Genomic Study of Monogastric Age-Associated Archaea
Feehan, B.; Ran, Q.; Dorman, V.; Rumback, K.; Pogranichniy, S.; Ward, K.; Goodband, R.; Niederwerder, M.; Lee, S. T. M.
10.1101/2022.12.03.518977 — microbiology — Posted on 2022-12-04
3468 Biosynthesis of pleuromutilin congeners using an Aspergillus oryzae expression platform
Alberti, F.; Khairudin, K.; Davies, J. A.; Sangmalee, S.; Willis, C. L.; Foster, G. D.; Bailey, A. M.
10.1101/2022.12.03.518960 — microbiology — Posted on 2022-12-04
3470 Integrated proteomics reveals the landscape of autophagy degradation in human neurons and autophagy receptors regulating neuronal activity
Yue, Z.; Zhou, X.; Lee, Y.-K.; Li, X.; Kim, H.; Priego, C. S.; Han, X.; Tan, H.; Zhou, S.; Fu, Y.; Purtell, K.; Wang, Q.; Holstein, G.; Tang, B.; Peng, J.; Yang, N.
10.1101/2022.12.04.519029 — neuroscience — Posted on 2022-12-04
3471 Enhancing associative learning in rats with a computationally designed training protocol
Zhang, X. O.; Zhang, Y.; Cho, C. E.; Engelke, D. S.; Smolen, P.; Byrne, J. H.; Do Monte, F. H.
10.1101/2022.06.08.495364 — neuroscience — Posted on 2022-12-04
3473 A novel type of monocytic leukemia stem cell revealed by the clinical use of venetoclax-based therapy
Pei, S.; Gillen, A. E.; Shelton, I. T.; Stevens, B. M.; Gasparetto, M.; Engel, K.; Staggs, S.; Wang, Y.; Showers, W.; Inguva, A.; Amaya, M. L.; Minhajuddin, M.; Winters, A.; Patel, S. B.; Tolison, H.; Krug, A.; Young, T. N.; Schowinsky, J.; McMahon, C.; Smith, C. A.; Pollyea, D. A.; Jordan, C. T.
10.1101/2022.12.04.519036 — cancer biology — Posted on 2022-12-04
3480 Structural basis for substrate recruitment by AMBRA1 E3 ligase receptor
Liu, M.; Wang, Y.; Teng, F.; Mai, X.; Xi, W.; Su, M.-Y.; Stjepanovic, G.
10.1101/2022.12.04.519012 — biochemistry — Posted on 2022-12-04
3484 Conformational dynamics of cohesin/Scc2 loading complex are regulated by Smc3 acetylation and ATP binding
Kaushik, A.; Than, T.; Petela, N. J.; Voulgaris, M.; Percival, C.; Daniels, P.; Rafferty, J. B.; Nasmyth, K. A.; Hu, B.
10.1101/2022.12.04.519023 — biochemistry — Posted on 2022-12-04
3485 Non-targeted metabolomics identifies erythronate accumulation in cancer cells
Zhang, J.; Keibler, M. A.; Dong, W.; Ghelfi, J.; Cordes, T.; Kanashova, T.; Pailot, A.; Linster, C.; Dittmar, G.; Metallo, C. M.; Lautenschlaeger, T.; Hiller, K.; Stephanopoulos, G.
10.1101/2022.12.04.519010 — biochemistry — Posted on 2022-12-04
3488 Microbial symbionts are shared between ants and their associated beetles
Valdivia, C.; Newton, J. A.; O'Donnell, S.; von Beeren, C.; Kronauer, D. J. C.; Russell, J. A.; Lukasik, P.
10.1101/2022.12.02.518891 — ecology — Posted on 2022-12-04
3493 Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
Yu, Y.; Gao, S. M.; Guan, Y.; Hu, P.; Zhang, Q.; Liu, J.; Jing, B.; Zhao, Q.; Sabatini, D. M.; Abu-Remaileh, M.; Jung, S. Y.; Wang, M. C.
10.1101/2022.10.16.512400 — cell biology — Posted on 2022-12-04
3494 Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function
Popovic, B.; Nicolet, B. P.; Guislain, A.; Engels, S.; Jurgens, A. P.; Paravinja, N.; Freen-van Heeren, J. J.; van Alphen, F. P.; van den Biggelaar, M.; Salerno, F.; Wolkers, M. C.
10.1101/2021.11.03.467112 — immunology — Posted on 2022-12-04
3495 Oncogenic metabolic rewiring independent of proliferative control in human mammary epithelial cells
Dong, W.; Keibler, M. A.; Moon, S. J.; Cho, P.; Liu, N.; Berrios, C. J.; Kelleher, J.; Sikes, H. D.; Iliopoulos, O.; Coloff, J.; Vander Heiden, M.; Stephanopoulos, G.
10.1101/2022.04.08.486845 — biochemistry — Posted on 2022-12-04
3496 An Ecological Approach to the Effects of Water-Source Locations and Time-Based Schedules on Entropy and Spatio-Temporal Behavioral Features
Hernandez-Eslava, V.; Leon, A.; Guzman, I.; Diaz, F.; Avendano-Garrido, M. L.; Toledo, P.; Hernandez-Linares, C. A.; Luna, I.
10.1101/2021.07.15.452514 — animal behavior and cognition — Posted on 2022-12-04
3497 Y chromosome sequence and epigenomic reconstruction across human populations
Esteller-Cucala, P.; Palmada-Flores, M.; Kuderna, L. F. K.; Fontsere, C.; Serres-Armero, A.; Dabad, M.; Torralvo, M.; Faella, A.; Ferrandez-Peral, L.; Llovera, L.; Fornas, O.; Julia, E.; Ramirez, E.; Gonzalez, I.; Hecht, J.; Lizano, E.; Juan, D.; Marques-Bonet, T.
10.1101/2022.12.02.518894 — genomics — Posted on 2022-12-04
3500 Brevicidine, a bacterial non-ribosomally produced cyclic antimicrobial lipopeptide with a unique modus operandi
Zhao, X.; Zhong, X.; Wan, H.; Liu, L.; Song, X.; Zou, Y.; Li, L.; Jia, R.; Lin, J.; Tang, H.; Ye, G.; Yang, J.; Zhao, S.; Lang, Y.; Yin, Z.; Kuipers, O. P.
10.1101/2022.10.07.511251 — microbiology — Posted on 2022-12-04
3501 An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction
Sumida, T. S.; Lincoln, M. R.; He, L.; Park, Y.; Ota, M.; Stillwell, H. A.; Leissa, G. A.; Fujio, K.; Kulminski, A.; Epstein, C. B.; Bernstein, B. E.; Kellis, M.; Hafler, D. A.
10.1101/2022.12.02.518871 — immunology — Posted on 2022-12-04
3504 Locus coeruleus neuromelanin predicts ease of attaining and maintaining neural states of high attentiveness
Hussain, S.; Menchaca, I.; Shalchy, M. A.; Yaghoubi, K.; langley, j.; Seitz, A.; Hu, X.; Peters, M. A. K.
10.1101/2022.03.07.483289 — neuroscience — Posted on 2022-12-04
3511 No evidence for a common blood microbiome based on a population study of 9,770 healthy humans
Tan, C. C. S.; Ko, K. K. K.; Chen, H.; Liu, J.; Loh, M.; SG10K_Health Consortium, ; Chia, M.; Nagarajan, N.
10.1101/2022.07.29.502098 — microbiology — Posted on 2022-12-04
3512 Extensive RNA editing in tomato nuclear genes
Xue, J.-Y.; Fan, H.-Y.; Zhen, Z.; Zhou, Y.-H.; Hu, S.-Y.; Li, S.-X.; Chen, Y.-J.; Chen, F.; Van de Peer, Y.; Shao, Z.-Q.
10.1101/2022.12.01.518646 — plant biology — Posted on 2022-12-04
3513 The developmental basis for scaling of mammalian tooth size
Christensen, M. M.; Hallikas, O.; Das Roy, R.; Vaananen, V.; Stenberg, O. E.; Hakkinen, T. J.; Francois, J.-C.; Asher, R. J.; Klein, O. D.; Holzenberger, M.; Jernvall, J.
10.1101/2022.12.03.518730 — developmental biology — Posted on 2022-12-03
3514 Optical-quality assessment of a miniaturized intraocular telescope
Nepita, I.; Raimondi, R.; Piazza, S.; Diaspro, A.; Vidal-Aroca, F.; Surdo, S.; Romano, M. R.
10.1101/2022.12.02.518911 — biophysics — Posted on 2022-12-03
3523 Transcriptomic and DNA methylation modifications during fruit ripening and in response to ABA treatment in sweet cherry
Kuhn, N.; Arellano, M.; Ponce, C.; Hodar, C.; Correa, F.; Multari, S.; Martens, S.; Carrera, E.; Donoso, J. M.; Meisel, L. A.
10.1101/2022.12.02.518926 — plant biology — Posted on 2022-12-03
3524 Ovule cell wall composition is a maternal determinant of grain size in barley
Yang, X.; Wilkinson, L. G.; Aubert, M. K.; Houston, K.; Shirley, N.; Tucker, M. R.
10.1101/2022.12.02.518939 — plant biology — Posted on 2022-12-03
3525 Plant architecture is correlated with variation in cannabinoid concentration and biomass production in Cannabis sativa
Stack, G. M.; Carlson, C. H.; Toth, J. A.; Philippe, G.; Crawford, J. L.; Hansen, J. L.; Viands, D. R.; Rose, J. K. C.; Smart, L. B.
10.1101/2022.12.02.518916 — plant biology — Posted on 2022-12-03
3526 Cytokinin synthesis and export from symbiotic root nodules coordinates shoot growth with nitrogen fixation
Chen, Y.; Liu, J.; Lin, J.; Roswanjaya, Y. P.; Nadzieja, M.; Buron, F.; Kohlen, W.; Geisler, M.; Stougaard, J.; Reid, D.
10.1101/2022.12.03.518951 — plant biology — Posted on 2022-12-03
3533 A cortical circuit for orchestrating oromanual food manipulation
An, X.; Matho, K. S.; Li, Y.; Mohan, H.; Xu, X. H.; Whishaw, I.; Kepecs, A.; Huang, Z. J.
10.1101/2022.12.03.518964 — neuroscience — Posted on 2022-12-03
3534 Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome
Rosenberger, F. A.; Thielert, M. A.; Strauss, M. T.; Ammar, C.; Maedler, S. C.; Schweizer, L.; Metousis, A.; Skowronek, P.; Wahle, M.; Schniering, J.; Semenova, A.; Schiller, H. B.; Rodriguez, E.; Nordmann, T. M.; Mund, A.; Mann, M.
10.1101/2022.12.03.518957 — systems biology — Posted on 2022-12-03
3535 Realtime observation of ATP-driven single B12 molecule translocationthrough BtuCD-F
Zhu, L.; Kim, J.; Leng, K.; Ramos, J. E.; Kinz-Thompson, C. D.; Karpowich, N. K.; Gonzalez, R. L.; Hunt, J. F.
10.1101/2022.12.02.518935 — biophysics — Posted on 2022-12-03
3536 Mechanistic implications of the interaction of the soluble substrate-binding protein with a type II ABC importer
Zhu, L.; Kim, J.; Leng, K.; Ramos, J. E.; Kinz-Thompson, C. D.; Karpowich, N. K.; Gonzalez, R. L.; Hunt, J. F.
10.1101/2022.12.02.518933 — biophysics — Posted on 2022-12-03
3538 Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein
Stelfox, A. J.; Oguntuyo, K. Y.; Rissanen, I.; Harlos, K.; Rambo, R.; Lee, B.; Bowden, T. A.
10.1101/2022.12.02.518945 — biochemistry — Posted on 2022-12-03
3541 Investigating the genetic diversity of H5 avian influenza in the UK 2020-2022
Byrne, A. M.; James, J.; Mollett, B. C.; Meyer, S. M.; Lewis, T.; Czepiel, M.; Seekings, A. H.; Mahmood, S.; Thomas, S. S.; Ross, C. S.; Byrne, D. J.; McMenamy, M. J.; Bailie, V.; Lemon, K.; Hansen, R. D.; Falchieri, M.; Lewis, N. S.; Reid, S. M.; Brown, I. H.; Banyard, A. C.
10.1101/2022.12.03.518823 — molecular biology — Posted on 2022-12-03
3542 Highly diverse and unknown viruses may enhance Antarctic endoliths' adaptability
Ettinger, C. L.; Saunders, M.; Selbmann, L. L.; Delgado-Baquerizo, M.; Donati, C.; Albanese, D.; Roux, S.; Tringe, S.; Pennacchio, C.; del Rio, T. G.; Stajich, J. E.; Coleine, C.
10.1101/2022.12.02.518905 — microbiology — Posted on 2022-12-03
3544 Consilience in disease ecology: FMDV transmission dynamics reflect viral growth and immune response rates.
Macdonald, J. C.; Gulbudak, H.; Beechler, B.; Gorsich, E.; Gubbins, S.; Perez-Martin, E.; Jolles, A.
10.1101/2022.12.02.518883 — ecology — Posted on 2022-12-03
3545 Higher-order thalamic nuclei facilitate the generalization and maintenance of spike-and-wave discharges in absence seizures
Atherton, Z.; Nagy, O.; Barcsai, L.; Sere, P.; Zsigri, N.; Földi, T.; Berenyi, A.; Crunelli, V.; Lorincz, M.
10.1101/2022.12.02.518853 — neuroscience — Posted on 2022-12-03
3546 Leaf ontogeny steers ethylene and auxin crosstalk to regulate leaf epinasty during waterlogging of tomato
Geldhof, B.; Pattyn, J.; Mohorovic, P.; Van den Broeck, K.; Everaerts, V.; Novak, O.; Van de Poel, B.
10.1101/2022.12.02.518836 — plant biology — Posted on 2022-12-03
3548 Dietary sugar and protein exert opposing effects on key larval growth and metabolic regulators, the Drosophila insulin-like peptides Dilp2 and Dilp6.
Suzawa, M.; McPherson, W. K.; Van Gorder, E. E.; Reddy, S.; Hilovsky, D. L.; Keliinui, C. N.; Jamali, L. A.; Bland, M. L.
10.1101/2022.12.01.518785 — physiology — Posted on 2022-12-03
3549 The E-cadherin-ESR1-GRPR axis defines a sex-specific metastatic pathway in melanoma
Raymond, J. H.; Schonau, M.; Petit, V.; Aktary, Z.; Luciani, F.; Wehbe, M.; Davidson, I.; Tomasetto, C.-L.; Mahuteau-Betzer, F.; Vergier, B.; Larue, L.; Delmas, V.
10.1101/2022.12.02.518844 — cancer biology — Posted on 2022-12-03
3554 Biomechanical characterisation of thoracic ascending aorta with preserved pre-stresses
Parikh, S.; Moerman, K. M.; Ramakers, M. J. F. G.; Schalla, S.; Bidar, E.; Delhaas, T.; Reesink, K.; Huberts, W.
10.1101/2022.12.02.518810 — bioengineering — Posted on 2022-12-03
3556 Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse model gene expression reversion
Wilk, E. J.; Howton, T. C.; Fisher, J. L.; Oza, V. H.; Brownlee, R. T.; McPherson, K. C.; Cleary, H. L.; Yoder, B. K.; George, J. F.; Mrug, M.; Lasseigne, B. N.
10.1101/2022.12.02.518863 — genomics — Posted on 2022-12-03
3557 Extensive RNA editing in tomato nuclear genes
Xue, J.-Y.; Fan, H.-Y.; Zhen, Z.; Zhou, Y.-H.; Hu, S.-Y.; Li, S.-X.; Chen, Y.-J.; Chen, F.; Van de Peer, Y.; Shao, Z.-Q.
10.1101/2022.12.01.518646 — genomics — Posted on 2022-12-03
3563 Identification of microbial exopolymer producers in sandy and muddy intertidal sediments by compound-specific isotope analysis
Hubas, C.; Gaubert-Boussarie, J.; D'Hondt, A.-S.; Jesus, B.; Lamy, D.; Meleder, V.; Prins, A.; Rosa, P.; Stock, W.; Sabbe, K.
10.1101/2022.12.02.516908 — ecology — Posted on 2022-12-03
3564 Challenges of Proper Disposal of Old Long-Lasting Insecticidal Nets and its Alternative Uses in Rural South-Eastern Tanzania
Salum, S. J.; Mponzi, W. P.; Muyaga, L. L.; Nkya, J. D.; Mwalugelo, Y. A.; Finda, M. F.; Msuya, H. M.; Lwetoijera, D. W.; Kaindoa, E. W.
10.1101/2022.12.01.518794 — ecology — Posted on 2022-12-03
3566 Autophagy degrades immunogenic endogenous retroelements induced by 5-azacytidine in acute myeloid leukemia
Noronha, N.; Durette, C.; E Silva, B.; Courtois, J.; Humeau, J.; Sauvat, A.; Hardy, M.-P.; Vincent, K.; Laverdure, J.-P.; Lanoix, J.; Baron, F.; Thibault, P.; Perreault, C.; Ehx, G.
10.1101/2022.12.02.518683 — immunology — Posted on 2022-12-03
3567 Using TCR and BCR sequencing to unravel the role of T and B cells in abdominal aortic aneurysm
Elster, C.; Ommer-Bläsius, M.; Lang, A.; Vajen, T.; Pfeiler, S.; Feige, M.; Le Quy, K.; Chernigovskaya, M.; Kelm, M.; Winkels, H.; Schmidt, S. V.; Greiff, V.; Gerdes, N.
10.1101/2022.12.01.518788 — immunology — Posted on 2022-12-03
3568 An Autoimmune Transcriptional Circuit Driving Foxp3+ Regulatory T cell Dysfunction
Hafler, D. A.; Sumida, T. S.; Lincoln, M. R.; He, L.; Park, Y.; Ota, M.; Stillwell, H. A.; Leissa, G. A.; Fujio, K.; Kulminski, A.; Epstein, C. B.; Bernstein, B. E.; Kellis, M.
10.1101/2022.12.02.518871 — immunology — Posted on 2022-12-03
3571 Subcapsular sinus macrophage sensing of extracellular matrix rigidity alters membrane topography and immune complex mobility
Iliopoulou, M.; Bajur, A. T.; McArthur, H. C.; Coyle, C.; Ajao, F.; Köchl, R.; Cope, A. P.; Spillane, K. M.
10.1101/2022.12.02.518873 — immunology — Posted on 2022-12-03
3573 Robust dimethyl-based multiplex-DIA workflow doubles single-cell proteome depth via a reference channel
Thielert, M.; Itang, C. E. M.; Ammar, C.; Schober, F. A.; Bludau, I.; Skowronek, P.; Wahle, M.; Zeng, W.-F.; Zhou, X.-X.; Brunner, A.-D.; Richter, S.; Theis, F. J.; Steger, M.; Mann, M.
10.1101/2022.12.02.518917 — systems biology — Posted on 2022-12-03
3581 Allosteric SHP2 Inhibition Increases Apoptotic Dependency on BCL2 and Synergizes with Venetoclax in FLT3- and KIT- Mutant AML
Popescu, B.; Stahlhut, C.; Tarver, T. C.; Wishner, S.; Lee, B. J.; Peretz, C. A. C.; Luck, C.; Phojanakong, P.; Camara Serrano, J. A.; Hongo, H.; Rivera, J. M.; Xirenayi, S.; Chukinas, J. A.; Steri, V.; Tasian, S. K.; Stieglitz, E.; Smith, C. C.
10.1101/2022.12.01.518665 — cancer biology — Posted on 2022-12-03
3583 Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling
Huang, X. X.; Ng, L. M.; Lee, P.-H.; Guan, P.; Chow, M. J.; Binte Mohamed Bashir, A.; Lau, M.; Tan, K.; Li, Z.; Chan, J.; Hong, J.; Ng, S. R.; Teo, H. L.; Rhodes, D.; Tan, P.; Tan, P. H.; McDonnell, D. P.; Teh, B. T.
10.1101/2022.12.01.518133 — cancer biology — Posted on 2022-12-03
3586 Novel native extracellular matrix probes to target patient- and tissue- specific cell-microenvironment interactions by force spectroscopy
Holuigue, H.; Nacci, L.; Di Chiaro, P.; Chighizola, M.; Locatelli, I.; Schulte, C.; Alfano, M.; Diaferia, G. R.; Podesta', A.
10.1101/2022.12.02.518867 — biophysics — Posted on 2022-12-03
3587 Selective volumetric excitation and imaging for single molecule localization microscopy in multicellular systems
Galgani, T.; Fedala, Y.; Zapata, R.; Caccianini, L.; Viasnoff, V.; Sibarita, J.-B.; Galland, R.; HAJJ, B.
10.1101/2022.12.02.518828 — biophysics — Posted on 2022-12-03
3589 Mutated cells mediate distinct inflammatory responses in clonal hematopoiesis
Heimlich, J. B.; Bhat, P.; Parker, A. C.; Jenkins, M. T.; Vlasschaert, C.; Ulloa, J.; Potts, C. R.; Olson, S.; Silver, A. J.; Ahmad, A.; Sharber, B.; Brown, D.; Hu, N.; van Galen, P.; Savona, M. R.; Bick, A. G.; Ferrell, P. B.
10.1101/2022.12.01.518580 — genetics — Posted on 2022-12-03
3590 Molecular signatures of alternative fitness strategies in a facultatively social hover wasp
Taylor, B. A.; Taylor, D.; Bodrug-Schepers, A.; Camara Ferreira, F.; Stralis-Pavese, N.; Himmelbauer, H.; Guigo, R.; Reuter, M.; Sumner, S.
10.1101/2022.12.02.518827 — evolutionary biology — Posted on 2022-12-03
3592 Investigation on key aspects of mating biology in the mosquito Aedes koreicus
Ciocchetta, S.; Frentiu, F. D.; Montarsi, F.; Capelli, G.; Devine, G. J.
10.1101/2022.12.01.518615 — ecology — Posted on 2022-12-03
3593 Immortalized bovine satellite cells for cultured meat applications
Stout, A. J.; Arnett, M. J.; Chai, K. M.; Guo, T.; Liao, L.; Mirliani, A. B.; Rittenberg, M. L.; Shub, M.; White, E. C.; Yuen, J. S. K.; Zhang, X.; Kaplan, D. L.
10.1101/2022.12.02.518927 — cell biology — Posted on 2022-12-03
3596 Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons
Qian, J.; Guan, X.; Xie, B.; Xu, C.; Niu, J.; Tang, X.; Li, C.; Colecraft, H.; Jaenisch, R.; Liu, X. S.
10.1101/2022.11.30.518560 — physiology — Posted on 2022-12-03
3597 Designing microplate layouts using artificial intelligence
Francisco Rodriguez, M. A.; Carreras-Puigvert, J.; Spjuth, O.
10.1101/2022.03.31.486595 — bioinformatics — Posted on 2022-12-03
3598 Lignin Composites with Sustained Oxygenation and Reactive Oxygen Species-Scavenging Improve Neovascularization and Healing of Diabetic Wounds
Padon, B. W.; Olutoye, O. O.; Short, W. D.; Kaul, A. A.; Yutzy, L. D.; Faruk, F.; Jung, O. S.; Kogan, P.; Yu, L.; Li, H.; Jung, J. P.; Balaji, S.
10.1101/2022.06.18.496670 — bioengineering — Posted on 2022-12-03
3599 Multiomic single-cell lineage tracing to dissect fate-specific gene regulatory programs
Jindal, K.; Adil, M. T.; Yamaguchi, N.; Yang, X.; Wang, H. C.; Kamimoto, K.; Rivera-Gonzalez, G. C.; Morris, S. A.
10.1101/2022.10.23.512790 — genomics — Posted on 2022-12-03
3600 Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis
Roth-Carter, Q. R.; Burks, H. E.; Ren, Z.; Koetsier, J. L.; Tsoi, L. C.; Harms, P. W.; Xing, X.; Kirma, J.; Harmon, R. M.; Godsel, L. M.; Perl, A. L.; Gudjonsson, J. E.; Green, K. J.
10.1101/2022.12.02.518412 — genomics — Posted on 2022-12-03
3601 Kinetic networks identify Twist2 as a key regulatory node in adipogenesis
Dutta, A. B.; Lank, D. S.; Przanowska, R. K.; Przanowski, P.; Wang, L.; Ngyuen, B.; Walavalkar, N. M.; Duarte, F. M.; Guertin, M. J.
10.1101/2021.11.17.469040 — genomics — Posted on 2022-12-03
3604 Diel population dynamics and mortality of Prochlorococcus in the North Pacific Subtropical Gyre
Beckett, S. J.; Demory, D.; Coenen, A. R.; Casey, J. R.; Dugenne, M.; Follett, C. L.; Connell, P.; Carlson, M. C. G.; Hu, S. K.; Wilson, S. T.; Muratore, D.; Rodriguez-Gonzalez, R. A.; Peng, S.; Becker, K. W.; Mende, D. R.; Armbrust, E. V.; Caron, D. A.; Lindell, D.; White, A. E.; Ribalet, F.; Weitz, J. S.
10.1101/2021.06.15.448546 — ecology — Posted on 2022-12-03
3605 Implications of the 375W mutation for HIV-1 tropism and vaccine development.
Verdejo-Torres, O.; Vargas-Pavia, T.; Fatima, S.; Clapham, P. R.; Duenas-Decamp, M. J.
10.1101/2022.08.29.505747 — microbiology — Posted on 2022-12-03
3606 4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses
Lieber, C. M.; Aggarwal, M.; Yoon, J.-J.; Cox, R.; Sourimant, J.; Toots, M.; Kang, H.-J.; Johnson, S. K.; Jones, C. A.; Sticher, Z. M.; Kolykhalov, A.; Sindaine, M. T.; Tompkins, S. M.; Planz, O.; Painter, G. R.; Natchus, M. G.; Sakamoto, K.; Plemper, R. K.
10.1101/2022.11.05.515296 — microbiology — Posted on 2022-12-03
3607 Single-cell Landscape Analysis of the Human Circulating B Cell Pool under Selective Pressure of Allogeneic Stem Cell Transplantation
Poe, J. C.; Fang, J.; Zhang, D.; Lee, M. R.; DiCioccio, R. A.; Su, H.; Qin, X.; Zhang, J.; Visentin, J.; Bracken, S. J.; Ho, V. T.; Wang, K. S.; Rose, J. J.; Pavletic, S. Z.; Hakim, F. T.; Jia, W.; Suthers, A. N.; Curry-Chisolm, I.; Horwitz, M. E.; Rizzieri, D. A.; McManigle, W.; Chao, N. J.; Cardones, A. R.; Xie, J.; Owzar, K.; Sarantopoulos, S.
10.1101/2022.10.13.512162 — immunology — Posted on 2022-12-03
3608 A searchable image resource of Drosophila GAL4-driver expression patterns with single neuron resolution
Meissner, G. W.; Nern, A.; Dorman, Z.; DePasquale, G. M.; Forster, K.; Gibney, T.; Hausenfluck, J. H.; He, Y.; Iyer, N.; Jeter, J.; Johnson, L.; Johnston, R. M.; Lee, K.; Melton, B.; Yarbrough, B.; Zugates, C. T.; Clements, J.; Goina, C.; Otsuna, H.; Rokicki, K.; Svirskas, R. R.; Aso, Y.; Card, G. M.; Dickson, B. J.; Ehrhardt, E.; Goldammer, J.; Ito, M.; Kainmueller, D.; Korff, W.; Mais, L.; Minegishi, R.; Namiki, S.; Rubin, G. M.; Sterne, G. R.; Wolff, T.; Malkesman, O.; FlyLight Project Team,
10.1101/2020.05.29.080473 — neuroscience — Posted on 2022-12-03
3610 Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease
Kulkarni, S.; Saha, M.; Slosberg, J.; Singh, A.; Nagaraj, S.; Becker, L. S.; Zhang, C.; Bukowski, A.; Wang, Z.; Liu, G.; Leser, J.; Kumar, M.; Bakhshi, S.; Anderson, M. J.; Lewandoski, M.; Vincent, E.; Goff, L.; Pasricha, P. J.
10.1101/2020.08.25.262832 — neuroscience — Posted on 2022-12-03
3611 Pathophysiology of Dyt1 dystonia is mediated by spinal cord dysfunction
Pocratsky, A. M.; Nascimento, F.; Özyurt, M. G.; White, I. J.; Sullivan, R.; O'Callaghan, B. J.; Smith, C. C.; Surana, S.; Beato, M.; Brownstone, R. M.
10.1101/2022.05.05.490750 — neuroscience — Posted on 2022-12-03
3613 HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5
Jacobs, C.; Shah, S.; Lu, W.-C.; Ray, H.; Wang, J.; Nephew, K.; Lu, X.; Cao, S.; Carpenter, R. L.
10.1101/2022.05.12.491688 — cancer biology — Posted on 2022-12-03
3614 A Web-based Software Resource for Interactive Analysis of Multiplex Tissue Imaging Datasets
Creason, A. L.; Watson, C.; Gu, Q.; Persson, D.; Sargent, L. L.; Chen, Y.-A.; Lin, J.-R.; Sivagnanam, S.; Wünnemann, F.; Nirmal, A. J.; Chin, K.; Feiler, H. S.; Coussens, L. M.; Schapiro, D.; Grüning, B. A.; Sorger, P. K.; Sokolov, A.; Goecks, J.
10.1101/2022.08.18.504436 — bioinformatics — Posted on 2022-12-03
3615 Predicting and Interpreting Protein Developability via Transfer of Convolutional Sequence Representation
Golinski, A. W.; Schmitz, Z. D.; Nielson, G. H.; Johnson, B.; Saha, D.; Appiah, S.; Hackel, B. J.; Martiniani, S.
10.1101/2022.11.21.517400 — bioinformatics — Posted on 2022-12-03
3616 A Self-attention Graph Convolutional Network for Precision Multi-tumour Early Diagnostics with DNA Methylation Data
Jiang, X.; Li, Z.; Mehmood, A.; Wang, H.; Wang, Q.; Chu, Y.; Mao, X.; Zhao, J.; Jiang, M.; Zhao, B.; Lin, G.; Wang, E.; Wei, D.-q.
10.1101/2022.02.11.480173 — bioinformatics — Posted on 2022-12-03
3617 Y chromosome sequence and epigenomic reconstruction across human populations
Esteller-Cucala, P.; Palmada-Flores, M.; Kuderna, L. F. K.; Fontsere, C.; Serres-Armero, A.; Dabad, M.; Torralvo, M.; Faella, A.; Ferrandez-Peral, L.; Llovera, L.; Fornas, O.; Julia, E.; Ramirez, E.; Gonzalez, I.; Hecht, J.; Lizano, E.; Juan, D.; Marques-Bonet, T.; Marques-Bonet, T.
10.1101/2022.12.02.518894 — genomics — Posted on 2022-12-02
3618 MicroRNA-27a is essential for bone remodeling by modulating p62-mediated osteoclast signaling
Wang, S.; Maruyama, E. O.; Martinez, J.; Lopes, J.; Hsu, T.; Wu, W.; Maruyama, T.; Hsu, W.
10.1101/2022.06.13.495939 — developmental biology — Posted on 2022-12-03
3619 Mean-field approximation of network of biophysical neurons driven by conductance-based ion exchange
Bandyopadhyay, A.; Rabuffo, G.; Calabrese, C.; Gudibanda, K.; Depannemaecker, D.; Ivanov, A. I.; bernard, c.; Jirsa, V.; Petkoski, S.
10.1101/2021.10.29.466427 — neuroscience — Posted on 2022-12-03
3622 Growth/differentiation factor 15 controls number of ependymal and neural stem cells in the ventricular/subventricular zone
Baur, K.; Carrillo Garcia, C.; San, S.; von Hahn, M.; Strelau, J.; Hölzl-Wenig, G.; Mandl, C.; Ciccolini, F.
10.1101/2022.12.02.518869 — neuroscience — Posted on 2022-12-02
3623 Multimodal, multiscale connectivity blueprints of the cerebral cortex
Hansen, J. Y.; Shafiei, G.; Voigt, K.; Liang, E.; Cox, S. M.; Leyton, M.; Jamadar, S. D.; Misic, B.
10.1101/2022.12.02.518906 — neuroscience — Posted on 2022-12-02
3625 Candida khanbhai sp. nov., a new clinically relevant yeast within the Candida haemulonii species complex
de Jong, A.; Al-Obaid, K.; Mohd Tap, R.; Gerrits van den Ende, B.; Groenewald, M.; Joseph, L.; Ahmad, S.; Hagen, F.
10.1101/2022.12.01.518802 — microbiology — Posted on 2022-12-02
3626 Evolutionary Inspired Engineering of Megasynthetases
Bozhueyuek, K. A. J.; Praeve, L.; Kegler, C.; Kaiser, S.; Shi, Y.-N.; Kuttenlochner, W.; Schenk, L.; Groll, M.; Hochberg, G. K. A.; Bode, H. B.
10.1101/2022.12.02.518901 — synthetic biology — Posted on 2022-12-02
3631 An ESCRT-dependent pathway of Nuclear and Cytoplasmic Spatial PQC is coordinated at Nuclear Vacuolar Junctions
Sontag, E. M.; Morales-Polanco, F.; Chen, J.-H.; McDermott, G.; Dolan, P. T.; Gestaut, D. R.; LeGros, M. A.; Larabell, C.; Frydman, J.
10.1101/2022.12.01.518779 — biochemistry — Posted on 2022-12-02
3632 Structure of LRRK1 and mechanisms of autoinhibition and activation
Reimer, J. M.; Dickey, A. M.; Lin, Y. X.; Abrisch, R. G.; Mathea, S.; Chatterjee, D.; Fay, E. J.; Daugherty, M. D.; Reck-Peterson, S. L.; Leschziner, A. E.
10.1101/2022.11.22.517582 — biochemistry — Posted on 2022-12-02
3637 Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner
Fu, X.; Zhuang, Q.; Babarinde, I. A.; Shi, L.; Ma, G.; Hu, H.; Li, Y.; Chen, J.; Xiao, Z.; Deng, B.; Sun, L.; Jauch, R.; Hutchins, A.
10.1101/2022.12.01.518778 — cell biology — Posted on 2022-12-02
3638 The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking
Neumann, D. P.; Pillman, K. A.; Dredge, B. K.; Bert, A. G.; Bracken, C. P.; Hollier, B. G.; Selth, L. A.; Beilharz, T. H.; Goodall, G. J.; Gregory, P. A.
10.1101/2022.12.01.518773 — molecular biology — Posted on 2022-12-02
3640 The Klebsiella pneumoniae ter operon enhances stress tolerance
Mason, S.; Vornhagen, J.; Smith, S. N.; Mike, L. A.; Mobley, H. A.; Bachman, M. A.
10.1101/2022.12.02.518861 — microbiology — Posted on 2022-12-02
3641 Isolation and Characterization of the Lytic Bacteriophages and Its Application in Combination with Amoxicillin against Aeromonas dhakensis
Sawaengwong, T.; Sunthornthummas, S.; Wongyoo, R.; Surachat, K.; Rangsiruji, A.; Atithep, T.; Sarawaneeyaruk, S.; Doi, K.; Nantavisai, K.; Insian, K.; Pomwised, R.; Pringsulaka, O.
10.1101/2022.12.01.518801 — microbiology — Posted on 2022-12-02
3643 Sensorimotor feedback loops are selectively sensitive to reward
Codol, O.; Kashefi, M.; Forgaard, C. J.; Galea, J. M.; Pruszynski, J. A.; Gribble, P. L.
10.1101/2021.09.16.460659 — neuroscience — Posted on 2022-12-02
3644 Multisite Thalamic Recordings to Characterize Seizure Propagation in the Human Brain
Wu, T. Q.; Kaboodvand, N.; Veit, M.; McGinn, R. J.; Davey, Z.; Datta, A.; Graber, K. D.; Meador, K. J.; Fisher, R.; Buch, V.; Parvizi, J.
10.1101/2022.12.01.518775 — neuroscience — Posted on 2022-12-02
3646 Multiphasic value biases in fast-paced decisions
Corbett, E. A.; Martinez-Rodriguez, L. A.; Judd, C.; O'Connell, R. G.; Kelly, S. P.
10.1101/2021.03.08.434248 — neuroscience — Posted on 2022-12-02
3647 Smurfness-based two-phase model of ageing helps deconvolve the ageing transcriptional signature
Zane, F.; Bouzid, H.; Besse, S.; Sosa Marmol, S.; Molina, J. L.; Cansell, C.; Aprahamian, F.; Durand, S.; Ayache, J.; Antoniewski, C.; Rera, M.
10.1101/2022.11.22.517330 — systems biology — Posted on 2022-12-02
3652 Microlenses fabricated by two-photon laser polymerisation for intravital cell imaging with non-linear excitation microscopy
Marini, M.; Nardini, A.; Martinez Vazquez, R.; Conci, C.; Bouzin, M.; Collini, M.; Osellame, R.; Cerullo, G.; Kariman, B. S.; Farsari, M.; Kabouraki, E.; Raimondi, M. T.; Chirico, G.
10.1101/2022.11.17.516871 — bioengineering — Posted on 2022-12-02
3653 Photoactivatable large Stokes shift fluorophores for multicolor nanoscopy
Likhotkin, I.; Lincoln, R.; Bossi, M. L.; Butkevich, A. N.; Hell, S. W.
10.1101/2022.12.02.518850 — biochemistry — Posted on 2022-12-02
3654 Disease-Associated Non-Coding Variants Alter NKX2-5 DNA-Binding Affinity
Pena-Martinez, E. G.; Rivera-Madera, A.; Pomales-Matos, D. A.; Sanabria-Alberto, L.; Rosario-Canuelas, B. M.; Rodriguez-Rios, J. M.; Carrasquillo-Dones, E. A.; Rodriguez-Martinez, J. A.
10.1101/2022.12.02.518772 — biochemistry — Posted on 2022-12-02
3656 Viral burdens are associated with age and viral variant in a population-representative study of SARS-CoV-2 that accounts for time-since-infection related sampling bias.
Fryer, H.; Golubchik, T.; Hall, M. D.; Fraser, C.; Hinch, R.; Ferretti, L.; Thomson, L.; Nurtey, A.; Pellis, L.; MackIntyre-Cockett, G.; Trebes, A.; Buck, D.; Piazza, P.; Green, A.; Lonie, L. J.; Smith, D.; Bashton, M.; Crown, M.; Nelson, A.; McCann, C. M.; Tariq, A.; Dos Santos, R. N.; Richards, Z.; The COVID-19 Genomics UK (COG-UK) consortium, ; Bonsall, D.; Lythgoe, K.
10.1101/2022.12.02.518847 — genetics — Posted on 2022-12-02
3661 Development of an Ectopic huLiver Model for Plasmodium Liver Stage Infection
Samayoa-Reyes, G.; Flaherty, S. M.; Wickham, K. S.; Viera-Morilla, S.; Strauch, P. M.; Roth, A.; Padron, L.; Jackson, C. M.; Meireles, P.; Calvo, D.; Roobsoong, W.; Kangwanrangsan, N.; Sattabongkot, J.; Reichard, G.; Lafuente-Monasterio, M. J.; Rochford, R.
10.1101/2022.12.01.518796 — molecular biology — Posted on 2022-12-02
3663 Metagenome-derived virus-microbe ratios across ecosystems
Lopez-Garcia, P.; Gutierrez-Preciado, A.; Krupovic, M.; Ciobanu, M.; Deschamps, P.; Jardillier, L.; Lopez-Perez, M.; Rodriguez-Valera, F.; Moreira, D.
10.1101/2021.02.17.431581 — microbiology — Posted on 2022-12-02
3664 Specific interaction between Group B Streptococcus CC17 hypervirulent clone and phagocytes
Bourrel, A.-S.; Picart, A.; Fernandez, J.-C.; Hays, C.; Saubamea, B.; Mignon, V.; Poyart, C.; Tazi, A.; Guignot, J.
10.1101/2022.12.02.518834 — microbiology — Posted on 2022-12-02
3665 Known mechanisms account for less than half of antimicrobial resistance in a diverse collection of non-aureus staphylococci.
Felgate, H.; Crossman, L. C.; Gray, E.; Clifford, R.; Correia, A.; Dean, R.; Wain, J.; Langridge, G. C.
10.1101/2021.06.22.449369 — microbiology — Posted on 2022-12-02
3667 Guanine crystals discovered in bacteria
Pavan, M. E.; Movilla, F.; Pavan, E.; Di Salvo, F.; Lopez, N. I.; Pettinari, M. J.
10.1101/2022.12.02.518751 — microbiology — Posted on 2022-12-02
3669 Permeation Across the Mycomembrane in Live Mycobacteria
Liu, Z.; Lepori, I.; Dalesandro, B. E.; Chordia, M. D.; Dong, J.; Siegrist, M. S.; Pires, M.
10.1101/2022.10.12.509737 — microbiology — Posted on 2022-12-02
3670 Development of non-alcoholic steatohepatitis is associated with gut microbiota but not oxysterol synthesis
Wyss, J.; Raselli, T.; Wyss, A.; Telzerow, A.; Rogler, G.; Krupka, N.; Yilmaz, B.; Schmidt, T. S.; Misselwitz, B.
10.1101/2022.12.02.518833 — microbiology — Posted on 2022-12-02
3671 Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses
Adeoye, B.; Nakiyingi, L.; Moreau, Y.; Nankya, E.; Olson, A. J.; Zhang, M.; Jacobson, K. R.; Gupta, A.; Manabe, Y.; Hosseinipour, M. C.; Kumwenda, J.; Sagar, M.
10.1101/2022.12.02.518812 — microbiology — Posted on 2022-12-02
3673 Quantification of bacterial DNA in blood using droplet digital PCR: a pilot study
Tedim, A. P.; Merino, I.; Ortega, A.; Dominguez-Gil, M.; Eiros, J. M.; Bermejo-Martin, J. F.
10.1101/2022.12.02.518639 — microbiology — Posted on 2022-12-02
3674 The interplay of uncertainty, relevance and learning influences auditory categorization
Sheth, J.; Collina, J.; Piasini, E.; Kording, K. P.; Cohen, Y.; Geffen, M. N.
10.1101/2022.12.01.518777 — neuroscience — Posted on 2022-12-02
3675 Supraorbital whiskers act as wind-antennae in rat anemotaxis
Mugnaini, M.; Mehrotra, D.; Davoine, F.; Sharma, V.; Mendes, A. R.; Gerhardt, B.; Concha-Miranda, M.; Brecht, M.; Clemens, A. M.
10.1101/2022.08.18.504295 — neuroscience — Posted on 2022-12-02
3678 Accurate quantification of single-nucleus and single-cell RNA-seq transcripts
Eldjarn Hjörleifsson, K.; Sullivan, D. K.; Holley, G.; Melsted, P.; Pachter, L.
10.1101/2022.12.02.518832 — bioinformatics — Posted on 2022-12-02
3679 The structural basis of the multi-step allosteric activation of Aurora B kinase
Segura-Pena, D.; Hovet, O.; Gogoi, H.; Dawicki-McKenna, J. M.; Hansen Woien, S. M.; Carrer, M.; Black, B. E.; Cascella, M.; Sekulic, N.
10.1101/2022.11.23.517677 — biochemistry — Posted on 2022-12-02
3680 The plant nuclear lamina disassembles to regulate genome folding in stress conditions
WANG, N.; Wang, Z.; Tzourtzou, S.; Wang, X.; Bi, X.; Leimeister, J.; Xu, L.; Sakamoto, T.; Matsunaga, S.; Schaller, A.; Jiang, H.; Liu, C.
10.1101/2022.12.01.517823 — genomics — Posted on 2022-12-02
3684 Mycobacterium tuberculosis-specific CD4 T cells expressing transcription factors associate with bacterial control in granulomas
Grant, N. L.; Kelly, K.; Maiello, P.; Abbott, H.; O'Connor, S. L.; Lin, P. L.; Scanga, C. A.; Flynn, J. L.
10.1101/2022.11.30.518638 — immunology — Posted on 2022-12-02
3686 Prenatal development has stable and consistent effects on the human brain throughout the lifespan
Walhovd, K. B.; Krogsrud, S. K.; Amlien, I. K.; Sorensen, O.; Wang, Y.; Brathen, A. C. S.; Overbye, K.; Kransberg, J.; Mowinckel, A. M.; Magnussen, F.; Herud, M.; Haberg, A. K.; Fjell, A. M.; Vidal-Pineiro, D.
10.1101/2022.12.02.514196 — neuroscience — Posted on 2022-12-02
3687 Drug repurposing of dopaminergic drugs to inhibit Ataxin-3 aggregation
Figueiredo, F.; Sarkany, Z.; Silva, A.; Martins, P. M.; Macedo-Ribeiro, S.
10.1101/2022.12.01.518659 — neuroscience — Posted on 2022-12-02
3689 Species-dependent actions of the Gαob selective adenosine A1 receptor agonist BnOCPA
Hill, E.; Huang, X.; Del Popolo, I.; La Mache, C.; Lochner, M.; Ladds, G.; Frenguelli, B. G.; Wall, M.
10.1101/2022.12.02.518704 — neuroscience — Posted on 2022-12-02
3691 Illuminating protein space with a programmable generative model
Ingraham, J.; Baranov, M.; Costello, Z.; Frappier, V.; Ismail, A.; Tie, S.; Wang, W.; Xue, V.; Obermeyer, F.; Beam, A.; Grigoryan, G.
10.1101/2022.12.01.518682 — bioinformatics — Posted on 2022-12-02
3692 Anemonefish have finer color discrimination in the ultraviolet
Mitchell, L. J.; Phelan, A.; Cortesi, F.; Marshall, J. N.; Chung, W.-S.; Osorio, D. C.; Cheney, K. L.
10.1101/2022.12.01.518784 — animal behavior and cognition — Posted on 2022-12-02
3693 Shifting effects of host physiological condition following pathogen establishment
Langwig, K. E.; Kilpatrick, A. M. M.; Kailing, M. J.; Laggan, N.; White, J. P.; Kaarakka, H. M.; Redell, J. A.; DePue, J. E.; Parise, K. L.; Foster, J. T.; Hoyt, J. R.
10.1101/2022.12.01.518758 — ecology — Posted on 2022-12-02
3694 Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes
Flinn, M.; Alvarez-Argote, S.; Knas, M. C.; Alencar, V.; Paddock, S. J.; Zhou, X.; Buddell, T.; Jamal, A.; Liu, P.; Drnevich, J.; Patterson, M.; Link, B.; O'Meara, C. C.
10.1101/2022.12.01.518714 — physiology — Posted on 2022-12-02
3695 Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation
Zhao, W.; Huang, X.; Yang, J.; Qiu, G.; Qu, L.; Zhao, Y.; Zhao, S.; Luo, Z.; Wang, X.; Jiu, Y.; Mao, H.; Ding, X.; Tan, J.; Hu, Y.; Pan, L.; Chen, L.; Li, H.
10.1101/2022.12.01.518675 — biophysics — Posted on 2022-12-02
3697 Secure and Federated Genome-Wide Association Studies for Biobank-Scale Datasets
Cho, H.; Froelicher, D.; Chen, J.; Edupalli, M.; Pyrgelis, A.; Troncoso-Pastoriza, J. R.; Hubaux, J.-P.; Berger, B.
10.1101/2022.11.30.518537 — bioinformatics — Posted on 2022-12-02
3698 MLcps: Machine Learning Cumulative Performance Score for classification problems
Akshay, A.; Abedi, M.; Shekarchizadeh, N.; Burkhard, F. C.; Katoch, M.; Bigger-Allen, A.; Adam, R. M.; Monastyrskaya, K.; Hashemi Gheinani, A.
10.1101/2022.12.01.518728 — bioinformatics — Posted on 2022-12-02
3700 TissUUmaps 3 Tools for Visualization & Quality Control in Large-scale Multiplex Tissue Analysis
Behanova, A.; Avenel, C.; Andersson, A.; Chelebian, E.; Klemm, A.; Wik, L.; Ostman, A.; Wahlby, C.
10.1101/2022.12.01.518716 — bioinformatics — Posted on 2022-12-02
3703 The type 1 diabetes-associated lncRNA ARGI participates in virus-induced pancreatic beta cell inflammation.
Gonzalez-Moro, I.; Garcia-Etxebarria, K.; Mendoza, L. M.; Fernandez-Jiminez, N.; Mentxaka-Salgado, J.; Olazagoitia-Garmendia, A.; Arroyo, M. N.; Sawatani, T.; Op de Beek, A.; Cnop, M.; Igoillo-Esteve, M.; Santin, I.
10.1101/2022.12.01.518685 — genetics — Posted on 2022-12-02
3710 Mice Humanized for Major Histocompatibility Complex and Angiotensin-Converting Enzyme 2 with High Permissiveness to SARS-CoV-2 Omicron Replication
Le Chevalier, F.; Authie, P.; Chardenoux, S.; Bourgine, M.; Vesin, B.; Cussigh, D.; Sassier, Y.; Fert, I.; Noirat, A.; Nemirov, K.; ANNA, F.; BERARD, M.; Guinet, F.; Hardy, D.; Charneau, P.; Lemonnier, F.; Langa-Vives, F.; MAJLESSI, L.
10.1101/2022.12.01.518541 — microbiology — Posted on 2022-12-02
3711 CD244 regulates both innate and adaptive immune axes in melanoma by inhibiting autophagy-mediated M1 macrophage maturation
Kim, J.; Kim, T.-J.; Chae, S.; Park, S.; Ha, H.; Park, Y.; Yoon, C. J.; Kim, J.; Kim, J.; Im, K.; Lee, H.; Lee, K.; Kim, J.; Kim, D.; Lee, E.; Shin, M. H.; Park, S. I.; Rhee, I.; Lee, J.; Lee, K. H.; Hwang, D.; Lee, K.-M.
10.1101/2022.12.01.518620 — immunology — Posted on 2022-12-02
3712 Signaling Node at TSC2 S1365 Potently Regulates T-Cell Differentiation and Improves Adoptive Cellular Cancer Therapy
Kass, D. A.; Powell, J. D.; Patel, C.; Dong, Y.; Dunkerly-Eyring, B. L.; Wen, J.; Ranek, M. J.; Bartle, L. M.; Henderson, D. B.; Sagart, J.
10.1101/2022.11.30.518569 — immunology — Posted on 2022-12-02
3713 Network topology in brain tumor patients with and without structural epilepsy- a prospective MEG-study
Ladisich, B.; Rampp, S.; Trinka, E.; Weisz, N.; Schwartz, C.; Kraus, T.; Sherif, C.; Marhold, F.; Demarchi, G.
10.1101/2022.12.01.518725 — neuroscience — Posted on 2022-12-02
3717 Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote symptoms of Parkinson's disease
Fang, P.; Espey, H.; Yu, L.; Agirman, G.; Li, K.; Deng, Y.; Lee, J.; Hncir, H.; Arnold, A. P.; Hsiao, E. Y.
10.1101/2022.11.30.518591 — physiology — Posted on 2022-12-02
3721 H3.1Cys96 oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistance
Palma, F. R.; Ogata, F. T.; Coelho, D. R.; Pulakanti, K.; Meyer, A.; Huang, Y.; Daves, J. M.; Schipma, M. J.; Furdui, C. M.; Spitz, D. R.; Gantner, B. N.; Rao, S.; Backman, V.; Bonini, M. G.
10.1101/2022.12.01.517361 — cancer biology — Posted on 2022-12-02
3722 Parabens Promote Pro-Tumorigenic Effects in Luminal Breast Cancer Cell Lines with Diverse Genetic Ancestry
Tapia, J. L.; McDonough, J. C.; Cauble, E. L.; Gonzalez, C. G.; Teteh, D. K.; Trevino, L. S.
10.1101/2022.12.01.518556 — cancer biology — Posted on 2022-12-02
3724 Viability of HepG2 and MCF-7 Cells is not Correlated with Mitochondrial Bioenergetics
Doczi, J.; Karnok, N.; Bui, D.; Azarov, V.; Pallag, G.; Nazarian, S.; Czumbel, B.; Seyfried, T. N.; Chinopoulos, C.
10.1101/2022.12.01.518661 — cancer biology — Posted on 2022-12-02
3730 YOUNG PLASMA REJUVENATES BLOOD DNA METHYLATION PROFILE, PROLONGS MEAN LIFESPAN AND IMPROVES HEALTH IN OLD RATS
Chiavellini, P.; Canatelli-Mallat, M.; Lehmann, M.; Zoller, J. A.; Gordevicius, J.; Gallardo, M. D.; PAsquini, D. C.; Herenu, C. B.; Morel, G. R.; 'Horvath,, S.; Goya, R. G.
10.1101/2022.12.01.518747 — bioinformatics — Posted on 2022-12-02
3734 WASCO: A Wasserstein-based statistical tool to compare conformational ensembles of intrinsically disordered proteins
Gonzalez-Delgado, J.; Sagar, A.; Zanon, C.; Lindorff-Larsen, K.; Bernado, P.; Neuvial, P.; Cortes, J.
10.1101/2022.12.01.518687 — bioinformatics — Posted on 2022-12-02
3736 Circular single-stranded DNA is a superior homology-directed repair donor template for efficient genome engineering
Xie, K.; Starzyk, J.; Majumdar, I.; Rincones, K.; Tran, T.; Lee, D.; Niemi, S.; Famiglietti, J.; Suter, B.; Shan, R.; Wu, H.
10.1101/2022.12.01.518578 — bioengineering — Posted on 2022-12-02
3737 Unclearing Microscopy
M'Saad, O.; Shribak, M.; Bewersdorf, J.
10.1101/2022.11.29.518361 — bioengineering — Posted on 2022-12-02
3738 Non-invasive in-blood glucose sensing
Uluc, N.; Glasl, S.; Juestel, D.; Pleitez, M. A.; Ntziachristos, V.
10.1101/2022.11.30.518508 — bioengineering — Posted on 2022-12-02
3740 Genomic analysis of Mycobacterium brumae sustains its nonpathogenic and immunogenic phenotype
Renau-Minguez, C.; Herrero-Abadia, P.; Sentandreu, V.; Ruiz-Rodriguez, P.; Torrents, E.; Chiner-Oms, A.; Torres-Puente, M.; Comas Espadas, I.; Julian, E.; Coscolla, M.
10.1101/2022.12.01.518671 — genetics — Posted on 2022-12-02
3742 Impacts of ocean acidification and warming on post-larval growth and metabolism in two populations of the great scallop (Pecten maximus L.)
Harney, E.; Rastrick, S. P. S.; Artigaud, S.; Pisapia, J.; Bernay, B.; Miner, P.; Pichereau, V.; Strand, O.; Boudry, P.; Charrier, G.
10.1101/2022.12.02.518857 — evolutionary biology — Posted on 2022-12-02
3744 Multiplexed microfluidic screening of bacterial chemotaxis
Stehnach, M. R.; Henshaw, R. J.; Floge, S. A.; Guasto, J. S.
10.1101/2022.11.30.518228 — ecology — Posted on 2022-12-02
3748 Adaptive remodeling of the gut microbiome over long-distance migration
Trevelline, B. K.; Sprockett, D.; DeLuca, W. V.; Andreadis, C. R.; Moeller, A. H.; Tonra, C. M.
10.1101/2022.11.30.518533 — ecology — Posted on 2022-12-02
3749 An epitope-enriched immunogen increases site targeting in germinal centers
Caradonna, T. M.; Windsor, I. W.; Roffler, A. R.; Song, S.; Watanabe, A.; Kelsoe, G.; Kuraoka, M.; Schmidt, A. G.
10.1101/2022.12.01.518697 — immunology — Posted on 2022-12-02
3750 Deficiency in hyaluronan synthase 3 attenuates ruptures in a murine model of abdominal aortic aneurysms by reduced aortic monocyte infiltration
Suvorava, T.; Brack, F.; Kaczur, J.; Petzsch, P.; Koehrer, K.; Quast, C.; Gerdes, N.; Voigt, K.; Krueger, M.; Fischer, J.; Brueckner, A.; Fleischmann, B. K.; Wenzel, D.; Zimmermann, L.-M. A.; Sengle, G.; Floegel, U.; Grandoch, M.
10.1101/2022.12.01.518480 — immunology — Posted on 2022-12-02
3751 Genetic identification and reiterated captures suggests that the Astyanax mexicanus El Pachon cavefish population is closed and declining
Legendre, L.; Rode, J.; Germon, I.; Pavie, M.; Quiviger, C.; Policarpo, M.; Leclercq, J.; Pere, S.; Fumey, J.; Hyacinthe, C.; Ornelas-Garcia, P.; Espinasa, L.; Retaux, S.; Casane, D.
10.1101/2022.12.01.518679 — zoology — Posted on 2022-12-02
3753 Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons
Qian, J.; Guan, X.; Xie, B.; Xu, C.; Niu, J.; Xin, T.; Li, C.; Colecraft, H.; Jaenisch, R.; Liu, X. S.
10.1101/2022.11.30.518560 — physiology — Posted on 2022-12-02
3754 Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
Bergman, R. F.; Lammlin, L.; Junginger, L.; Farrell, E.; Goldman, S.; Darcy, R.; Rasner, C.; Obeidat, A. M.; Malfait, A.-M.; Miller, R.; Maerz, T.
10.1101/2022.11.30.517736 — physiology — Posted on 2022-12-02
3756 MC1R drives cutaneous repair by promoting angiogenesis and lymphangiogenesis
Rocliffe, H. R.; Austin-Williams, S.; Krilis, G.; Zhou, K.; Ji, Y.; Bain, C.; Nawilaijaroen, Y.; Pellicoro, A.; Zhou, T.; Crichton, M.; Huang, Z.; Caporali, A.; Cash, J. L.
10.1101/2022.11.30.518516 — pathology — Posted on 2022-12-02
3757 High-throughput Approaches to Uncover Synergistic Drug Combinations in Leukemia
Chory, E. J.; Wang, M.; Ceribelli, M.; Michalowska, A. M.; Golas, S.; Beck, E.; Klumpp-Thomas, C.; Chen, L.; McKnight, C.; Itkin, Z.; Divakaran, S.; Bradner, J.; Khan, J.; Gryder, B. E.; Thomas, C. J.; Stanton, B. Z.
10.1101/2022.11.29.518409 — cancer biology — Posted on 2022-12-02
3762 TMvisDB: resource for transmembrane protein annotation and 3D visualization
Marquet, C.; Grekova, A.; Houri, L.; Bernhofer, M.; Jimenez-Soto, L.; Karl, T.; Heinzinger, M.; Dallago, C.; Rost, B.
10.1101/2022.11.30.518551 — bioinformatics — Posted on 2022-12-02
3763 Dynamic Data Independent Acquisition Mass Spectrometry with Real-Time Retrospective Alignment
Heil, L. R.; Remes, P. M.; Canterbury, J. D.; Yip, P.; Barshop, W. D.; Wu, C. C.; MacCoss, M. J.
10.1101/2022.11.29.518428 — bioinformatics — Posted on 2022-12-02
3766 A deep learning approach for improving two-photon vascular imaging speeds
Zhou, A.; Mihelic, S.; Engelmann, S.; Tomar, A.; Dunn, A. K.; Narasimhan, V. M.
10.1101/2022.11.30.518528 — bioengineering — Posted on 2022-12-02
3769 The host phylogeny determines viral infectivity and replication across Staphylococcus host species
Walsh, S. K.; Imrie, R. M.; Matuszewska, M. K.; Paterson, G. K.; Weinert, L. A.; Hadfield, J. D.; Buckling, A.; Longdon, B.
10.1101/2022.11.30.518513 — evolutionary biology — Posted on 2022-12-02
3770 Multiple paths towards repeated phenotypic evolution in the spiny-leg adaptive radiation (Tetragnatha; Hawaii)
Cerca, J.; Cotoras, D. D.; Santander, C. G.; Bieker, V. C.; Hutchins, L.; Morin-Lagos, J.; Prada, C. F.; Kennedy, S.; Krehenwinkel, H.; Rominger, A.; Meier, J.; Dimitrov, D.; Struck, T.; Gillespie, R. G.
10.1101/2022.11.29.518358 — evolutionary biology — Posted on 2022-12-02
3772 Euglenozoan kleptoplasty illuminates the early evolution of photoendosymbiosis
Karnkowska, A.; Yubuki, N.; Maruyama, M.; Yamaguchi, A.; Kashiyama, Y.; Suzaki, T.; Keeling, P. J.; Hampl, V.; Leander, B. S.
10.1101/2022.11.29.517283 — evolutionary biology — Posted on 2022-12-02
3773 Ecological and genetic trade-offs drive Arabidopsis thaliana range expansion in Europe
Bastias, C. C.; Estarague, A.; Vile, D.; Lee, C.-R.; Exposito-Alonso, M.; Violle, C.; Vasseur, F.
10.1101/2022.11.29.518298 — ecology — Posted on 2022-12-02
3776 Patterns of secondary invasion in the understory of exotic, invasive timber stands
Jobin, V.; Das, A.; Harikrishnan, C. P.; Chanda, R.; Lawrence, S.; Robin, V. V.
10.1101/2022.11.29.518341 — ecology — Posted on 2022-12-02
3778 Administration of amniotic fluid stem cell extracellular vesicles promotes development of fetal hypoplastic lungs by immunomodulating lung macrophages
Antounians, L.; Figueira, R. L.; Kukreja, B.; Zani-Ruttenstock, E.; Khalaj, K.; Montalva, L.; Doktor, F.; Obed, M.; Blundell, M.; Qu, T.; Chan, C.; Wagner, R.; Lacher, M.; Wilson, M. D.; Kalish, B.; Zani, A.
10.1101/2022.11.29.518388 — developmental biology — Posted on 2022-12-02
3781 Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in severe COVID-19
Essex, M.; Pascual-Leone, B. M.; Löber, U.; Kuhring, M.; Zhang, B.; Bruening, U.; Fritsche-Guenther, R.; Krzanowski, M.; Vernengo, F. F.; Brumhard, S.; Röwekamp, I.; Bielecka, A. A.; Lesker, T. R.; Wyler, E.; Landthaler, M.; Mantei, A.; Meisel, C.; Caesar, S.; Thiebeault, C.; Corman, V.; Marko, L.; Suttorp, N.; Strowig, T.; Kurth, F.; Sander, L. E.; Li, Y.; Kirwan, J. A.; Forslund, S. K.; Opitz, B.
10.1101/2022.12.02.518860 — systems biology — Posted on 2022-12-02
3782 Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice
Campbell, M. D.; Samuelson, A. T.; Chiao, Y. A.; Sweetwyne, M. T.; Ladiges, W. C.; Rabinovitch, P. S.; Marcinek, D.
10.1101/2022.11.29.518431 — physiology — Posted on 2022-12-02
3783 miR-29 is an important driver of aging-related phenotypes
Swahari, V.; Nakamura, A.; Hollville, E.; Hung, Y.-H.; Kanke, M.; Kurtz, C. L.; Caravia, X. M.; He, S.; Krishnamurthy, J.; Kapoor, S.; Prasad, V.; Flowers, C.; Beck, M.; Baran-Gale, J.; Sharpless, N.; Lopez-Otin, C.; Sethupathy, P.; Deshmukh, M.
10.1101/2022.11.29.518429 — physiology — Posted on 2022-12-02
3784 Acute adenoviral cardiac infection elicits an arrhythmogenic substrate prior to inflammatory myocardial remodeling and myocarditis
Padget, R. L.; Blair, G. A.; North, M. D.; Zeitz, M. J.; Tanenbaum, M. T.; King, D. R.; Hoeker, G. S.; Swanger, S. A.; Poelzing, S.; Smyth, J. W.
10.1101/2022.11.29.518421 — pathology — Posted on 2022-12-02
3785 ACR TI-RADS(R) Score Ultrasound - Pictorial Essay of Ultrasound / Elastosonography / Anatomy / Cytology and Histology.
Andrade, L. J. O.; Matos de Oliveira, L.; Bittencourt, A. M. V.; De Carvalho Lourenco, L. G.; Matos de Oliveira, G. C.
10.1101/2022.11.29.518434 — pathology — Posted on 2022-12-02
3787 Dual-color single molecule localization microscopy on transparent polymer waveguide chips
Engdahl, A. K.; Dutta, S. B.; Belle, S.; Schuerstedt, J.; Szafranska, K.; Hellmann, R.; McCourt, P.; Huser, T.; Schuettpelz, M.
10.1101/2022.11.29.518375 — biophysics — Posted on 2022-12-02
3794 Finemap-MiXeR: A variational Bayesian approach for genetic finemapping
Akdeniz, B. C.; Frei, O.; Shadrin, A.; Vetrov, D.; Kropotov, D.; Dale, A.; Hovig, E.; Andreassen, O.
10.1101/2022.11.30.518509 — bioinformatics — Posted on 2022-12-02
3795 Hypotrochoidal scaffolds for cartilage regeneration
van Kampen, K. A.; Olaret, E.; Stancu, I.-C.; Campos, D.; Fischer, H.; Mota, C.; Moroni, L.
10.1101/2022.11.29.518172 — bioengineering — Posted on 2022-12-02
3796 Synergizing algorithmic design, photoclick chemistry and multi-material volumetric printing for accelerating complex shape engineering
Chansoria, P.; Reutsche, D. R.; Wang, A.; Liu, H.; D'Angella, D.; Rizzo, R.; Hasenauer, A.; Weber, P.; Ibrahim, N. B. M.; Korshunova, N.; Zenobi-Wong, M.
10.1101/2022.11.29.518318 — bioengineering — Posted on 2022-12-02
3798 Cloud gazing: demonstrating paths for unlocking the value of cloud genomics through cross-cohort analysis
Deflaux, N.; Selvaraj, M. S.; Condon, H. R.; Mayo, K.; Haidermota, S.; Basford, M. A.; Lunt, C.; Philippakis, A. A.; Roden, D. M.; Denny, J. C.; Musick, A.; Collins, R.; Allen, N.; Effingham, M.; Glazer, D.; Natarajan, P.; Bick, A. G.
10.1101/2022.11.29.518423 — genetics — Posted on 2022-12-02
3799 Capturing the distribution as it shifts: chile pepper (Capsicum annuum L.) domestication gradient meets geography.
Martinez-Ainsworth, N. E.; Scheppler, H.; Moreno Letelier, A.; Bernau, V.; Kantar, M.; Mercer, K.; Jardon-Barbolla, L.
10.1101/2022.11.29.518324 — evolutionary biology — Posted on 2022-12-02
3800 Tree segmentation in airborne laser scanning data is only accurate for canopy trees
Cao, Y.; Ball, J. G. C.; Coomes, D. A.; Steinmeier, L.; Knapp, N.; Wilkes, P.; Disney, M.; Calders, K.; Burt, A.; Lin, Y.; Jackson, T. D.
10.1101/2022.11.29.518407 — ecology — Posted on 2022-12-02
3801 Impact of early insect herbivory on the invasive oak lace bug (Corythucha arcuata Say, 1832) in different oak species
Valdes-Correcher, E.; de Groot, M.; Schille, L.; Stemmelen, A.; Mellerin, Y.; Bonnard, O.; Castagneyrol, B.
10.1101/2022.11.30.518479 — ecology — Posted on 2022-12-02
3807 Arabidopsis hydathodes are sites of intense auxin metabolism and nutrient scavenging
Routaboul, J.-M.; Bellenot, C.; Clement, G.; Citerne, S.; Rembliere, C.; Charvin, M.; Franke, L.; Chiarenza, S.; Vasselon, D.; Jardinaud, M.-F.; Carrere, S.; NUSSAUME, L.; Laufs, P.; Leonhardt, N.; Navarro, L.; Schattat, M. H.; NOEL, L. D.
10.1101/2022.12.01.518666 — plant biology — Posted on 2022-12-02
3813 Programming bacteria to sense environmental DNA for multiplexed pathogen detection
Cheng, Y.-Y.; Chen, Z.; Cao, X.; Ross, T. D.; Falbel, T. G.; Burton, B. M.; Venturelli, O. S.
10.1101/2022.03.10.483875 — synthetic biology — Posted on 2022-12-02
3814 T-cell receptor specific protein language model for prediction and interpretation of epitope binding (ProtLM.TCR)
Essaghir, A.; Sathiyamoorthy, N. K.; Smyth, P.; Postelnicu, A.; Ghiviriga, S.; Ghita, A.; Singh, A.; Kapil, S.; Phogat, S.; Singh, G.
10.1101/2022.11.28.518167 — bioinformatics — Posted on 2022-12-02
3815 AcrNET: Predicting Anti-CRISPR with Deep Learning
Li, Y.; Wei, Y.; Xu, S.; Tan, Q.; Zong, L.; Wang, J.; Wang, Y.; Chen, J.; Hong, L.; Li, Y.
10.1101/2022.04.02.486820 — bioinformatics — Posted on 2022-12-02
3817 Landscape structure is a key driver of protist diversity along elevation gradients in the Swiss Alps
Seppey, C. V. W.; Lara, E.; Broennimann, O.; Guisan, A.; Malard, L.; Yashiro, E.; Fournier, B.
10.1101/2022.04.13.488160 — ecology — Posted on 2022-12-02
3819 Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of alpha-synuclein inclusions
Lam, I.; Ndayisaba, A.; Lewis, A. J.; Fu, Y.; Sagredo, G. T.; Zaccagnini, L.; Sandoe, J.; Sanz, R. L.; Vahdatshoar, A.; Martin, T. D.; Morshed, N.; Ichihashi, T.; Tripathi, A.; Ramalingam, N.; Oettgen-Suazo, C.; Bartels, T.; Schabinger, M.; Hallacli, E.; Jiang, X.; Verma, A.; Tea, C.; Wang, Z.; Hakozaki, H.; Yu, X.; Hyles, K.; Park, C.; Theunissen, T. W.; Wang, H.; Jaenisch, R.; Lindquist, S.; Stevens, B.; Stefanova, N.; Wenning, G.; Luk, K. C.; Sanchez Pernaute, R.; Gomez-Esteban, J. C.; Felsky, D.; Kiyota, Y.; Sahni, N.; Yi, S. S.; Chung, C.-Y.; Stahlberg, H.; Ferrer, I.; Schoneberg, J.; Ell
10.1101/2022.11.08.515615 — neuroscience — Posted on 2022-12-02
3820 Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment
Abdi, A. I.; Achcar, F.; Sollelis, L.; Silva-Filho, J. L.; Mwikali, K.; Muthui, M.; Mwangi, S.; Kimingi, H. W.; Orindi, B.; Andisi, C.; Alkema, M.; Chandrasekar, A.; Bull, P.; Bejon, P.; Modrzynska, K.; Bousema, T.; Marti, M.
10.1101/2022.11.29.518379 — microbiology — Posted on 2022-12-02
3821 In-depth Temporal Transcriptome Profiling of Monkeypox and Host Cells using Nanopore Sequencing
Kakuk, B.; Dormo, A.; Csabai, Z.; Kemenesi, G.; Holoubek, J.; Ruzek, D.; Prazsak, I.; Dani, V. E.; Denes, B.; Torma, G.; Jakab, F.; Toth, G. E.; Foldes, F. V.; Zana, B.; Lanszki, Z.; Harangozo, A.; Fulop, A.; Gulyas, G.; Mizik, M.; Kiss, A. A.; Tombacz, D.; Boldogkoi, Z.
10.1101/2022.11.28.518226 — microbiology — Posted on 2022-12-02
3823 BBIBP-CorV (Sinopharm) vaccination- induced immunity is affected by age, gender and prior COVID-19 and activates responses to spike and other antigens
Hasan, Z.; Masood, K. I.; Qaiser, S.; Khan, E.; Hussain, A.; Ghous, Z.; Khan, U.; Yameen, M.; Hassan, I.; Nisar, M. I.; Qazi, M. F.; Memon, H. A.; Ali, S.; Baloch, S.; Bhutta, Z. A.; Veldhoen, M.; Simas, J. P.; Mahmood, S. F.; Hussain, R.; Ghias, K.
10.1101/2022.11.30.518633 — immunology — Posted on 2022-12-02
3824 Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling
Wilbers, R.; Metodieva, V. D.; Duverdin, S.; Heyer, D. B.; Galakhova, A. A.; Mertens, E. J.; Versluis, T. D.; Baayen, J. C.; Idema, S.; Noske, D. P.; Verburg, N.; Willemse, R. B.; de Witt Hamer, P. C.; Kole, M. H. P.; de Kock, C. P. J.; Mansvelder, H. D.; Goriounova, N. A.
10.1101/2022.11.29.518317 — neuroscience — Posted on 2022-12-02
3825 DEFECTIVE KERNEL1 (DEK1) regulates cellulose synthesis and affects primary cell wall mechanics
Novakovic, L.; Yakubov, G. E.; Ma, Y.; Bacic, A.; Blank, K. G.; Sampathkumar, A.; Johnson, K. L.
10.1101/2022.11.29.518391 — plant biology — Posted on 2022-12-02
3826 The CD73 immune checkpoint promotes tumor cell metabolic fitness
Allard, D.; Cousineau, I.; Ma, E. H.; Allard, B.; Bareche, Y.; Fleury, H.; Stagg, J.
10.1101/2022.11.29.518350 — cancer biology — Posted on 2022-12-02
3827 A versatile method to archive and delipidate brain tissues for ensuing multiplexed immunolabeling and organ-level imaging
Lin, Y.-H.; Wang, L.-W.; Chen, Y.-H.; Chan, Y.-C.; Hu, S.-H.; Wu, S.-Y.; Chiang, C.-S.; Huang, G.-J.; Yang, S.-D.; Chu, S.-W.; Wang, K.-C.; Lin, C.-H.; Huang, P.-H.; Cheng, H.-J.; Chen, B.-C.; Chu, L.-A.
10.1101/2022.11.28.518189 — bioengineering — Posted on 2022-12-02
3828 Detecting population continuity and ghost admixture among ancient genomes
McKenna, J.; Sjodin, P.; Bernhardsson, C.; Waxman, D.; Jakobsson, M.
10.1101/2022.12.01.518676 — genetics — Posted on 2022-12-01
3829 Joint Multi-Ancestry and Admixed GWAS Reveals the Complex Genetics behind Human Cranial Vault Shape
Goovaerts, S.; Hoskens, H.; Eller, R. J.; Herrick, N.; Musolf, A. M.; Justice, C. M.; Yuan, M.; Naqvi, S.; Lee, M. K.; Vandermeulen, D.; Szabo-Rogers, H. L.; Romitti, P. A.; Boyadjiev, S. A.; Marazita, M. L.; Shaffer, J. R.; Shriver, M. D.; Wysocka, J.; Walsh, S.; Weinberg, S. M.; Claes, P.
10.1101/2022.12.01.518684 — genetics — Posted on 2022-12-02
3835 Histone H1.0 Couples Cellular Mechanical Behaviors to Chromatin Structure
Hu, S.; Chapski, D. J.; Gehred, N.; Kimball, T. H.; Gromova, T.; Flores, A.; Rowat, A. C.; Chen, J. J.; Packard, R. R. S.; Olszewski, E.; Davis, J.; Rau, C. D.; McKinsey, T. A.; Rosa-Garrido, M.; Vondriska, T. M.
10.1101/2022.11.29.518399 — cell biology — Posted on 2022-12-01
3839 Cortical networks relating to arousal are differentially coupled to neural activity and hemodynamics
Meyer-Baese, L.; Morrissette, A. E.; Wang, Y.; Le Chatelier, B.; Borden, P. Y.; Keilholz, S.; Stanley, G. B.; Jaeger, D.
10.1101/2022.12.01.518759 — neuroscience — Posted on 2022-12-01
3843 Toblerone: detecting exon deletion events in cancer using RNA-seq
Lonsdale, A.; Halman, A.; Brown, L.; Kosasih, H.; Ekert, P.; Oshlack, A.
10.1101/2022.10.27.514132 — bioinformatics — Posted on 2022-12-01
3844 Mannose-coupled AAV2: a second generation AAV vector for increased retinal gene therapy efficiency
MEVEL, M.; Pichard, V.; Bouzelha, M.; Alvarez-Dorta, D.; Lalys, P.-A.; Provost, N.; Allais, M.; Mendes, A.; Landagaray, E.; Ducloyer, J.-B.; Galy, A.; Brument, N.; Lefevre, G. M.; Gouin, S. G.; Isiegas, C.; Le Meur, G.; Cronin, T.; Le Guiner, C.; Weber, M.; Moullier, P.; Ayuso, E.; Deniaud, D.; Adjali, O.
10.1101/2022.12.01.518481 — bioengineering — Posted on 2022-12-01
3845 The complete sequence of a human Y chromosome
Rhie, A.; Nurk, S.; Cechova, M.; Hoyt, S. J.; Taylor, D. J.; Altemose, N.; Hook, P. W.; Koren, S.; Rautiainen, M.; Alexandrov, I. A.; Allen, J.; Asri, M.; Bzikadze, A. V.; Chen, N.-C.; Chin, C.-S.; Diekhans, M.; Flicek, P.; Formenti, G.; Fungtammasan, A.; Garcia Giron, C.; Garrison, E.; Gershman, A.; Gerton, J.; Grady, P. G.; Guarracino, A.; Haggerty, L.; Halabian, R.; Hansen, N. F.; Harris, R.; Hartley, G. A.; Harvey, W. T.; Haukness, M.; Heinz, J.; Hourlier, T.; Hubley, R. M.; Hunt, S. E.; Hwang, S.; Jain, M.; Kesharwani, R. K.; Lewis, A. P.; Li, H.; Logsdon, G. A.; Lucas, J. K.; Makalowski,
10.1101/2022.12.01.518724 — genomics — Posted on 2022-12-01
3846 Assembly of 43 diverse human Y chromosomes reveals extensive complexity and variation
Hallast, P.; Ebert, P.; Loftus, M.; Yilmaz, F.; Audano, P. A.; Logsdon, G. A.; Bonder, M. J.; Zhou, W.; Hoeps, W.; Kim, K.; Li, C.; Dishuck, P. C.; Porubsky, D.; Tsetsos, F.; Kwon, J. Y.; Zhu, Q.; Munson, K. M.; Hasenfeld, P.; Harvey, W. T.; Lewis, A. P.; Kordosky, J.; Hoekzema, K.; (HGSVC), T. H. G. S. V. C.; Korbel, J. O.; Tyler-Smith, C.; Eichler, E. E.; Shi, X.; Beck, C. R.; Marschall, T.; Konkel, M. K.; Lee, C.
10.1101/2022.12.01.518658 — genomics — Posted on 2022-12-01
3847 Liver transcriptomic and methylomic analyses identify transcriptional MAPK regulation in facultative hibernation of Syrian hamster
Oosterhof, M. M.; Coussement, L.; Guryev, V.; Reitsema, V. A.; Bruintjes, J. J.; Goris, M.; Bouma, H. R.; De Meyer, T.; Rots, M. G.; Henning, R. H.
10.1101/2022.12.01.518631 — genomics — Posted on 2022-12-01
3848 DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood
Issarapu, P.; Arumalla, M.; Elliott, H. R.; Nongmaithem, S. S.; Alagu, S.; Betts, M.; Sajjadi, S.; Kessler, N. J.; Bayyana, S.; Mansuri, S. R.; Derakhshan, M.; V, K. G.; Shrestha, S.; K, K.; Gravio, C. D.; Sahariah, S. A.; Sanderson, E.; Relton, C.; Ward, K. A.; Moore, S. E.; Prentice, A. M.; Lillycrop, K. A.; Fall, C. H. D.; Silver, M. J.; Chandak, G. R.
10.1101/2022.11.30.514849 — genomics — Posted on 2022-12-01
3850 Establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology
Kesapragada, M.; Sun, Y.-H.; Recendez, C.; Fregoso, D.; Yang, H.-y.; Isseroff, R. R.; Zhao, M.; Gomez, M.
10.1101/2022.11.29.518400 — cell biology — Posted on 2022-12-01
3851 Changes in gut microbiome composition drive fentanyl intake and striatal proteomic changes
Hofford, R. S.; Meckel, K. R.; Wang, W.; Kim, M.; Godino, A.; Lam, T. T.; Kiraly, D.
10.1101/2022.11.30.518531 — neuroscience — Posted on 2022-12-01
3856 AAV-mediated Expression of a Novel Conformational Anti-Aggregated alpha-Synuclein Antibody Prolongs Survival in a Genetic Model of alpha-Synucleinopathies
Duechs, M.; Blazevic, D.; Rechtsteiner, P.; Kenny, C.; Lamla, T.; Low, S.; Savistchenko, J.; Neumann, M.; Melki, R.; Schoenberger, T.; Stierstorfer, B.; Wyatt, D.; Igney, F.; Ciossek, T.
10.1101/2022.11.30.518485 — neuroscience — Posted on 2022-12-01
3858 Hypothalamic melanocortin-4 receptors on astrocytes mediate inflammation and body weight homeostasis
Eliason, N. L.; Pham, K.; Varshney, R.; Farriester, J. W.; Lacy, C. I.; Rice, H. C.; Rudolph, M. C.; Freeman, W. M.; Sharpe, A. L.
10.1101/2022.12.01.518727 — neuroscience — Posted on 2022-12-01
3859 Nigral-specific increase in ser31 tyrosine hydroxylase phosphorylation offsets dopamine loss and forestalls hypokinesia onset during progressive nigrostriatal neuron loss
Kasanga, E.; Han, Y.; Shifflet, M.; Navarrete, W.; McManus, R.; Parry, C.; Barhona, A.; Nejtek, V.; Richardson, J. R.; Salvatore, M. F.
10.1101/2022.11.29.518437 — neuroscience — Posted on 2022-12-01
3861 High-frequency longitudinal white matter diffusion- & myelin-based MRI database: reliability and variability
Edde, M.; Theuad, G.; Dumont, M.; Theberge, A.; Valcourt Caron, A.; Gilbert, G.; Houde, J.-C.; Maltais, L.; Rheault, F.; Spagnolo, F.; Barakovic, M.; Magon, S.; Descoteaux, M.
10.1101/2022.12.01.518514 — neuroscience — Posted on 2022-12-01
3862 Filter-based models of suppression in retinal ganglion cells: comparison and generalization across species and stimuli
Shahidi, N.; Rozenblit, F.; Khani, M. H.; Schreyer, H. M.; Mietsch, M.; Protti, D. A.; Gollisch, T.
10.1101/2022.12.01.518577 — neuroscience — Posted on 2022-12-01
3864 Altered lipid homeostasis underlies selective neurodegeneration in SNX14 deficiency
Zhou, Y.; Sanchez, V. B.; Xu, P.; Flores-Mendez, M.; Ciesielski, B.; Yoo, D.; Teshome, H.; Henne, M.; O'Brien, T.; Mesaros, C.; Akizu, N.
10.1101/2022.11.30.516463 — neuroscience — Posted on 2022-12-01
3866 Neural mechanisms of parasite-induced summiting behavior in 'zombie' Drosophila
Elya, C.; Lavrentovich, D.; Lee, E.; Pasadyn, C.; Duval, J.; Basak, M.; Saykina, V.; de Bivort, B. L.
10.1101/2022.12.01.518723 — neuroscience — Posted on 2022-12-01
3867 Emission of floral volatiles is facilitated by cell-wall non-specific lipid transfer proteins
Liao, P.; Maoz, I.; Shih, M.-L.; Lee, J. H.; Huang, X.-Q.; Morgan, J. A.; Dudareva, N.
10.1101/2022.11.30.518598 — plant biology — Posted on 2022-12-01
3868 Widening the landscape of transcriptional regulation of algal photoprotection
Arend, M.; Yuan, Y.; Ruiz-Sola, M. A.; Omranian, N.; Nikoloski, Z.; Petroutsos, D.
10.1101/2022.02.25.482034 — plant biology — Posted on 2022-12-01
3869 Chemical factors induce aggregative multicellularity in a close unicellular relative of animals
Ros-Rocher, N.; Kidner, R. Q.; Gerdt, C. T.; Davidson, W. S.; Ruiz-Trillo, I.; Gerdt, J. P.
10.1101/2022.12.01.517680 — biochemistry — Posted on 2022-12-01
3872 A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva
Shatilovich, A.; Gade, V. R.; Pippel, M.; Hoffmeyer, T. T.; Tchesunov, A. V.; Stevens, L.; Winkler, S.; Hughes, G. M.; Traikov, S.; Hiller, M.; Rivkina, E.; Schiffer, P. H.; Myers, E. W.; Kurzchalia, T. V.
10.1101/2022.01.28.478251 — genomics — Posted on 2022-12-01
3876 The telomere-to-telomere, gapless, phased diploid genome and methylome of the green alga Scenedesmus obliquus UTEX 3031 reveals significant heterozygosity and functional separation of the haplotypes
Biondi, T.; Kruse, C. P. S.; Koehler, S. I.; Kwon, T.; Eng, W.; Kunde, Y. A.; Gleasner, C. D.; You Mak, K. T.; Polle, J.; Hovde, B. T.; Hanschen, E. R.; Starkenburg, S. R.
10.1101/2022.11.30.518549 — genomics — Posted on 2022-12-01
3878 Universal closed-tube barcoding for monitoring the shark and ray trade in megadiverse conservation hotspots
Prasetyo, A. P.; Cusa, M.; Murray, J.; Agung, F.; Muttaqin, E.; Mariani, S.; McDevitt, A.
10.1101/2022.11.30.518468 — genetics — Posted on 2022-12-01
3879 Predator-mediated interactions through changes in predator home range size can lead to local prey exclusion
Beardsell, A.; Berteaux, D.; Dulude-de-Broin, F.; Gauthier, G.; Clermont, J.; Gravel, D.; Bety, J.
10.1101/2022.09.30.510100 — ecology — Posted on 2022-12-01
3880 Dual functions of labial resolve the Hox logic of chelicerate head segments
Gainett, G.; Klementz, B. C.; Blaszczyk, P. O.; Bruce, H.; Patel, N.; Sharma, P. P.
10.1101/2022.11.29.518396 — developmental biology — Posted on 2022-12-01
3881 A selectivity filter in the EMC limits protein mislocalization to the ER
Pleiner, T.; Hazu, M.; Tomaleri, G. P.; Nguyen, V. N.; Januszyk, K.; Voorhees, R. M.
10.1101/2022.11.29.518402 — cell biology — Posted on 2022-12-01
3883 Porcine and human aortic valve endothelial and interstitial cell isolation and characterization
Nehl, D.; Goody, P. R.; Maus, K.; Pfeifer, A.; Aikawa, E.; Bakhtiary, F.; Zimmer, S.; Nickenig, G.; Jansen, F.; Hosen, M. R.
10.1101/2022.12.01.518669 — cell biology — Posted on 2022-12-01
3884 Actin contraction controls nuclear blebbing and rupture independent of actin confinement
Pho, M.; Berrada, Y.; Gunda, A.; Lavallee, A.; Chiu, K.; Padam, A.; Currey, M. L.; Stephens, A. D.
10.1101/2022.12.01.518663 — cell biology — Posted on 2022-12-01
3887 The lncRNA landscape of cardiac resident macrophages and identification of Schlafenlnc as a regulator of macrophage migratory function
Dueck, A.; Althaus, L.; Heise, K.; Esfandyari, D.; Bayguen, S.; Brandes, R. P.; Gagneur, J.; Jae, N.; Knolle, P.; Leisegang, M. S.; Maegdefessel, L.; Meitinger, T.; Petzold, N.; Ramanujam, D.; Sager, H.; Schulz, C.; Theodorakis, E.; Uzonyi, A.; Weinberger, T.; Bader, M.; Schmidt-Supprian, M.; Engelhardt, S.
10.1101/2022.11.30.518576 — cell biology — Posted on 2022-12-01
3889 Platelets modulate inflammation and matrix remodeling in abdominal aortic aneurysm
Wagenhaeuser, M. U.; Mulorz, J.; Krott, K. J.; Feige, T.; Ehrenberg, A.; Rhee, Y. H.; Chatterjee, M.; Petzold, N.; Boeddeker, C.; Ibing, W.; Krueger, I.; Spin, J. M.; Tsao, P. S.; Roseman, A.; Schelzig, H.; Elvers, M.
10.1101/2022.12.01.518674 — molecular biology — Posted on 2022-12-01
3892 The potential role of human immune cells in the systemic dissemination of enterovirus-D68
Laksono, B. M.; Sooksawasdi Na Ayudhya, S.; Aguilar-Bretones, M.; Embregts, C. W. E.; van Nierop, G. P.; van Riel, D.
10.1101/2022.12.01.518644 — microbiology — Posted on 2022-12-01
3893 Podoplanin expression in fibroblasts determines lymph node architecture and adaptive immune function
Makris, S.; Hari-Gupta, Y.; Cantoral-Rebordinos, J. A.; Martinez, V. G.; Horsnell, H. L.; de Winde, C. M.; Singh, T.; Jovancheva, M.; Kettler, R.; Kriston-Vizi, J.; Acton, S. E.
10.1101/2022.12.01.518753 — immunology — Posted on 2022-12-01
3894 The development of efficient communication in the human connectome.
van Blooijs, D.; van den Boom, M. A.; van der Aar, J. F.; Huiskamp, G. J. M.; Castegnaro, G.; Demuru, M.; Zweiphenning, W. J. E. M.; van Eijsden, P.; Miller, K. J.; Leijten, F. S. S.; Hermes, D.
10.1101/2022.03.14.484297 — neuroscience — Posted on 2022-12-01
3895 Functional and microstructural plasticity following social and interoceptive mental training.
Valk, S. L.; Kanske, P.; Park, B.-y.; Hong, S.-J.; Boeckler, A.; Trautwein, F.-M.; Bernhardt, B. C.; Singer, T.
10.1101/2020.11.11.377895 — neuroscience — Posted on 2022-12-01
3896 The evolution of whole-brain turbulent dynamics during recovery from traumatic brain injury
Martinez-Molina, N.; Escrichs, A.; Sanz Perl, Y.; Sarkamo, T.; Sihvonen, A. J.; Kringelbach, M. L.; Deco, G.
10.1101/2022.11.30.518501 — neuroscience — Posted on 2022-12-01
3898 AUTS2 gene dosage affects synaptic AMPA receptors via a local dendritic spine AUTS2-TTC3-AKT-mTORC1 signaling dysfunction
Bestel, A.-M.; Duchon, A.; Viard, J.; Kvajo, M.; Daudin, R.; Khelfaoui, M.; Haziza, S.; Loe-Mie, Y.; Aime, M.; Suizu, F.; Birling, M.-C.; Bensaid, M.; Jacquot, S.; Koebel, P.; Reverdy, C.; Rain, J.-C.; Noguchi, M.; Marques, X.; Triller, A.; Humeau, Y.; Herault, Y.; Karayiorgou, M.; Gogos, J.; Simonneau, M.
10.1101/2022.12.01.518705 — neuroscience — Posted on 2022-12-01
3899 A chromatic feature detector in the retina signals visual context changes
Hoefling, L.; Szatko, K. P.; Behrens, C.; Qiu, Y.; Klindt, D. A.; Jessen, Z.; Schwartz, G. S.; Bethge, M.; Berens, P.; Franke, K.; Ecker, A. S.; Euler, T.
10.1101/2022.11.30.518492 — neuroscience — Posted on 2022-12-01
3900 Transcriptional lability of brain oxytocin receptor (Oxtr) generates diversity in brain OXTR distribution and social behaviors
Zhang, Q.; Kandasamy, L. C.; Tsukamoto, M.; Inoue, K.; Pires, M. F.; Shin, M.; Tanaka, M.; Nagasawa, Y.; Sambuu, T.; Itohara, S.; Ogawa, S.; Young, L. J.
10.1101/2022.12.01.518660 — neuroscience — Posted on 2022-12-01
3902 G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage
Pena, N.; Gonzalez-Hunt, C.; Qi, R.; Barlow, C.; Shanks, N. F.; Carlisle, H.; Sanders, L. H.
10.1101/2022.11.30.517979 — neuroscience — Posted on 2022-12-01
3904 Axonal ER tubules regulate local translation via P180/RRBP1-mediated ribosome interactions
Koppers, M.; Ozkan, N.; Nguyen, H. H.; Jurriens, D.; McCaughey, J.; Stucchi, R.; Altelaar, M.; Kapitein, L. C.; Hoogenraad, C. C.; Farias, G. G.
10.1101/2022.11.30.518484 — neuroscience — Posted on 2022-12-01
3912 Hippocampal engram networks for fear memory recruit new synapses and modify pre-existing synapses in vivo.
Lee, C.; Lee, B. H.; Jung, H.; Lee, C.; Sung, Y.; Kim, H.; Kim, J.; Shim, J. Y.; Kim, J.-i.; Choi, D. I.; Park, H. Y.; Kaang, B.-K.
10.1101/2022.11.29.518458 — neuroscience — Posted on 2022-12-01
3914 Modeling human eye movements during immersive visual search
Radulescu, A.; van Opheusden, B.; Callaway, F.; Griffiths, T. L.; Hillis, J. M.
10.1101/2022.12.01.518717 — neuroscience — Posted on 2022-12-01
3916 Hormonal gatekeeping via the blood brain barrier governs behavior
Ju, L.; Glastad, K. M.; Sheng, L.; Gospocic, J.; Kingwell, C. J.; Davidson, S. M.; Kocher, S. D.; Bonasio, R.; Berger, S. L.
10.1101/2022.12.01.518733 — neuroscience — Posted on 2022-12-01
3917 Age-specific mechanisms regulate neural crest and mesodermal contribution to the enteric nervous system in health and disease
Kulkarni, S.; Saha, M.; Singh, A.; Slosberg, J.; Nagaraj, S.; Becker, L. S.; Zhang, C.; Bukowski, A.; Wang, Z.; Liu, G.; Leser, J.; Kumar, M.; Bakhshi, S.; Anderson, M. J.; Lewandoski, M.; Vincent, E.; Goff, L.; Pasricha, P. J.
10.1101/2020.08.25.262832 — neuroscience — Posted on 2022-12-01
3918 Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells
Machold, R. P.; Dellal, S.; Valero, M.; Zurita, H.; Kruglikov, I.; Meng, J. H.; Hanson, J.; Hashikawa, Y.; Schuman, B.; Buzsaki, G.; Rudy, B.
10.1101/2022.12.01.518752 — neuroscience — Posted on 2022-12-01
3920 Behavioral discrimination and olfactory bulb encoding of odor plume intermittency
Gumaste, A.; Baker, K. L.; Izydorczak, M.; True, A. C.; Vasan, G.; Crimaldi, J. P.; Verhagen, J. V.
10.1101/2022.12.01.518694 — neuroscience — Posted on 2022-12-01
3922 Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets
Han, Y.; Yang, J.; Li, Y.; Cen, Y.; Ren, H.; Ding, R.; Qian, W.; Ren, K.; Xie, B.; Deng, M.; Xiao, Y.; Chu, J.; Zou, P.
10.1101/2022.12.01.518652 — neuroscience — Posted on 2022-12-01
3924 Impact of the cancer endocycle on cell survival after therapy
Kim, C.-J.; Gonye, A. L.; Truskowski, K.; Lee, C.-F.; Pienta, K. J.; Austin, R.; Amend, S. R.
10.1101/2022.09.19.508515 — cancer biology — Posted on 2022-12-01
3925 Keratinocyte desmosomal cadherin Desmoglein 1 as a mediator and target of paracrine signaling in the melanoma niche
Burks, H. E.; Pokorny, J. L.; Koetsier, J. L.; Roth-Carter, Q. R.; Arnette, C. R.; Gerami, P.; Seykora, J. T.; Johnson, J. L.; Green, K. J.
10.1101/2022.12.01.518424 — cancer biology — Posted on 2022-12-01
3929 Optimizing the Cell Painting assay for image-based profiling
Cimini, B. A.; Chandrasekaran, S. N.; Kost-Alimova, M.; Miller, L.; Goodale, A.; Fritchman, B.; Byrne, P.; Garg, S.; Jamali, N.; Logan, D. J.; Concannon, J. B.; Lardeau, C.-H.; Mouchet, E.; Singh, S.; Abbasi, H. S.; Aspesi, P.; Boyd, J. D.; Gilbert, T.; Gnutt, D.; Hariharan, S.; Hernandez, D.; Hormel, G.; Juhani, K.; Melanson, M.; Mervin, L.; Monteverde, T.; Pilling, J. E.; Skepner, A.; Swalley, S. E.; Vrcic, A.; Weisbart, E.; Williams, G.; Yu, S.; Zapiec, B.; Carpenter, A. E.
10.1101/2022.07.13.499171 — bioinformatics — Posted on 2022-12-01
3930 Comprehensive evaluation of methods for differential expression analysis of metatranscriptomics data
Cho, H.; Qu, Y.; Liu, C.; Tang, B.; Lyu, R.; Lin, B. M.; Roach, J.; de Ribeiro, A.; Love, M. I.; Divaris, K.; Wu, D.
10.1101/2021.07.14.452374 — bioinformatics — Posted on 2022-12-01
3934 Talin and vinculin combine their activities to trigger actin assembly
Wang, H.; Vigouroux, C.; Said, R.; Henriot, V.; Pernier, J.; Le Clainche, C.
10.1101/2022.12.01.518757 — biochemistry — Posted on 2022-12-01
3935 Optimization of host cell-compatible, antimicrobial peptides effective against biofilms and clinical isolates of drug-resistant bacteria.
Ghimire, J.; Hart, R. J.; Soldano, A.; Chen, C.; Guha, S.; Hoffmann, J. P.; Hall, K.; Sun, L.; Nelson, B. J.; Lu, T. K.; Kolls, J. K.; Rivera, M.; Morici, L. A.; Wimley, W. C.
10.1101/2022.12.01.518642 — biochemistry — Posted on 2022-12-01
3937 An Ecological Approach to the Effects of Water-Source Locations and Time-Based Schedules on Entropy and Spatio-Temporal Behavioral Features
Hernandez-Eslava, V.; Leon, A.; Guzman, I.; Diaz, F.; Avendano-Garrido, M. L.; Toledo, P.; Hernandez-Linares, C. A.; Luna, I.
10.1101/2021.07.15.452514 — animal behavior and cognition — Posted on 2022-12-01
3939 Massively parallel characterization of insulator activity across the genome
Hong, C. K.; Erickson, A. A.; Li, J.; Federico, A. J.; Cohen, B. A.
10.1101/2022.11.29.518444 — genomics — Posted on 2022-12-01
3944 Geothermal stickleback populations prefer cool water despite multigenerational exposure to a warm environment
Pilakouta, N.; Killen, S. S.; Kristjansson, B. K.; Skulason, S.; Lindström, J.; Metcalfe, N. B.; Parsons, K.
10.1101/615005 — evolutionary biology — Posted on 2022-12-01
3948 PI 3-kinase isoform p110alpha controls smooth muscle cell functionality and protects against aortic aneurysm formation
Vantler, M.; Schorscher, M.; Berghausen, E. M.; Moore, J. B.; Wong, D.; Zhaolong, L.; Wissmueller, M.; Gnatzy-Feik, L.; Zierden, M.; Mehrkens, D.; Adam, M.; Zhao, X.; Odenthal, M.; Sengle, G.; Boor, P.; Maegdefessel, L.; Baldus, S.; Rosenkranz, S.
10.1101/2022.12.01.518561 — cell biology — Posted on 2022-12-01
3949 The secretome of irradiated peripheral mononuclear cells attenuates hypertrophic skin scarring
Vorstandlechner, V.; Copic, D.; Klas, K.; Direder, M.; Golabi, B.; Radtke, C.; Ankersmit, H. J.; Mildner, M.
10.1101/2022.12.01.518726 — cell biology — Posted on 2022-12-01
3950 ZNF524 directly interacts with telomeric DNA and supports telomere integrity
Braun, H.; Xu, Z.; Chang, F.; Viceconte, N.; Rane, G.; Levin, M.; Lototska, L.; Roth, F.; Hillairet, A.; Fradera-Sola, A.; Khanchandani, V.; Dreesen, O.; Yang, Y.; Shi, Y.; Li, F.; Butter, F.; Kappei, D.
10.1101/2022.11.30.518500 — cell biology — Posted on 2022-12-01
3951 Centrosome formation in the bovine early embryo.
Uzbekov, R.; Singina, G.; Shedova, E.; Banliat, C.; Avidor-Reiss, T.; Uzbekova, S.
10.1101/2022.11.29.517493 — cell biology — Posted on 2022-12-01
3954 Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail
Chaban, A.; Minakhin, L.; Goldobina, E.; Bae, B.; Hao, Y.; Borukhov, S.; Putzeys, L.; Boon, M.; Lavigne, R.; Makarova, K. S.; Koonin, E. V.; Nair, S. K.; Tagami, S.; Severinov, K.; Sokolova, M. L.
10.1101/2022.12.01.518664 — molecular biology — Posted on 2022-12-01
3955 Mechanism of receptor assembly via the pleiotropic adipokine Leptin
Tsirigotaki, A.; Dansercoer, A.; Verschueren, K. H. G.; Markovic, I.; Pollmann, C.; Hafer, M.; Felix, J.; Birck, C.; Van Putte, W.; Catteeuw, D.; Tavernier, J.; Bazan, F. J.; Piehler, J.; Savvides, S. N.; Verstraete, K.
10.1101/2022.12.01.518327 — molecular biology — Posted on 2022-12-01
3957 Specialized metabolic convergence in the gut microbiomes of cycad-feeding insects tolerant to β-methylamino-L-alanine (BMAA)
Gutierrez-Garcia, K.; Whitaker, M. R. L.; Bustos-Diaz, E. D.; Salzman, S.; Ramos-Aboites, H. E.; Reitz, Z. L.; Pierce, N. E.; Cibrian-Jaramillo, A.; Barona-Gomez, F.
10.1101/2022.12.01.518742 — microbiology — Posted on 2022-12-01
3961 Synthetic extremophiles: Species-specific formulations for microbial therapeutics and beyond.
Jimenez, M.; L'Heureux, J.; Kolaya, E.; Martin, K. B.; Villaverde, Z.; Khazi-Syed, A.; Cao, Q.; Muller, B.; Byrne, J. D.; Traverso, G.
10.1101/2022.11.30.518573 — microbiology — Posted on 2022-12-01
3963 Mcr-dependent methanogenesis in Archaeoglobaceae enriched from a terrestrial hot spring
Buessecker, S.; Chadwick, G.; Quan, M. E.; Hedlund, B.; Dodsworth, J. A.; Dekas, A. E.
10.1101/2022.12.01.518715 — microbiology — Posted on 2022-12-01
3964 Hyperglycemia increases the severity of Staphylococcus aureus osteomyelitis and influences bacterial genes required for survival in bone.
Butrico, C. E.; Klopfenstein, N. B.; Green, E. R.; Johnson, J. R.; Peck, S. H.; Ibberson, C.; Serezani, C. H.; Cassat, J. E.
10.1101/2022.11.30.518635 — microbiology — Posted on 2022-12-01
3966 Modeling the Sequence Dependence of Differential Antibody Binding in the Immune Response to Infectious Disease
Chowdhury, R.; Taguchi, A. T.; Kelbauskas, L.; Stafford, P.; Diehnelt, C.; Zhao, Z.-G.; Williamson, P. C.; Green, V.; Woodbury, N. W.
10.1101/2022.11.30.518471 — immunology — Posted on 2022-12-01
3967 High resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex
Haenelt, D.; Trampel, R.; Nasr, S.; Polimeni, J.; Tootell, R. B.; Sereno, M. I.; Pine, K.; Edwards, L. J.; Helbling, S.; Weiskopf, N.
10.1101/2022.04.28.489865 — neuroscience — Posted on 2022-12-01
3973 SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response
Krawczyk, P. S.; Gewartowska, O.; Mazur, M.; Orzel, W.; Matylla-Kulinska, K.; Jelen, S.; Turowski, P.; Spiewla, T.; Tarkowski, B.; Tudek, A.; Brouze, A.; Wesolowska, A.; Nowis, D.; Golab, J.; Kowalska, J.; Jemielity, J.; Dziembowski, A.; Mroczek, S.
10.1101/2022.12.01.518149 — immunology — Posted on 2022-12-01
3977 Evaluation of epigenetic age acceleration scores and their associations with CVD related phenotypes in a population cohort
Chervova, O.; Chernysheva, E.; Panteleeva, K.; Widayati, T.; Hrbkova, N.; Schneider, J.; Maximov, V.; Ryabikov, A.; Tillmann, T.; Pikhart, H.; Bobak, M.; Voloshin, V.; Malyutina, S.; Beck, S.
10.1101/2022.07.06.498980 — bioinformatics — Posted on 2022-12-01
3978 An integrated view of baseline protein expression in human tissues
Prakash, A.; Garcia-Seisdedos, D.; Wang, S.; Kundu, D. J.; Collins, A.; George, N.; Moreno, P.; Papatheodorou, I.; Jones, A. R.; Vizcaino, J. A.
10.1101/2021.09.10.459811 — bioinformatics — Posted on 2022-12-01
3979 Enterobacterales plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches in Oxfordshire, UK
Matlock, W.; Lipworth, S.; Chau, K. K.; AbuOun, M.; Barker, L.; Kavanagh, J.; Andersson, M.; Oakley, S.; Morgan, M.; Crook, D. W.; Read, D. S.; Anjum, M.; Shaw, L. P.; Stoesser, N.; REHAB Consortium,
10.1101/2022.05.06.490774 — genomics — Posted on 2022-12-01
3980 A pathogen-induced putative NAC transcription factor mediates leaf rust resistance in barley
Chen, C.; Jost, M.; Outram, M. A.; Friendship, D.; Periyannan, S.; Bartos, J.; Holusova, K.; Zhang, P.; Bhatt, D.; Singh, D.; Lagudah, E.; Park, R.; Dracatos, P.
10.1101/2022.11.30.518475 — genetics — Posted on 2022-12-01
3982 Nirmatrelvir treatment blunts the development of antiviral adaptive immune responses in SARS-CoV-2 infected mice
Fumagalli, V.; Di Lucia, P.; Rava, M.; Marotta, D.; Bono, E.; Grassi, S.; Donnici, L.; Cannalire, R.; Stefanelli, I.; Ferraro, A.; Esposito, F.; Pariani, E.; Inverso, D.; Montesano, C.; Delbue, S.; Tramontano, E.; De Francesco, R.; Summa, V.; Guidotti, L.; Iannacone, M.
10.1101/2022.11.22.517465 — immunology — Posted on 2022-12-01
3983 A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva
Shatilovich, A.; Gade, V. R.; Pippel, M.; Hoffmeyer, T. T.; Tchesunov, A. V.; Stevens, L.; Winkler, S.; Hughes, G. M.; Traikov, S.; Hiller, M.; Rivkina, E.; Schiffer, P. H.; Myers, E. W.; Kurzchalia, T. V.
10.1101/2022.01.28.478251 — genomics — Posted on 2022-12-01
3989 Homophilic wiring principles underpin neuronal network topology in vitro
Akarca, D.; Dunn, A. W. E.; Hornauer, P. J.; Ronchi, S.; Fiscella, M.; Wang, C.; Terrigno, M.; Jagasia, R.; Vertes, P. E.; Mierau, S. B.; Paulsen, O.; Eglen, S. J.; Hierlemann, A.; Astle, D. E.; Schröter, M.
10.1101/2022.03.09.483605 — neuroscience — Posted on 2022-12-01
3994 Searching memory in time and space
Dougherty, M. R.; Chang, W.; Rudoler, J. H.; Katerman, B. S.; Halpern, D.; Bruska, J. P.; Diamond, N.; Kahana, M. J.
10.1101/2022.11.30.518606 — neuroscience — Posted on 2022-12-01
3995 Adult neurogenesis improves spatial information encoding in the mouse hippocampus
Frechou, M. A.; Martin, S. S.; McDermott, K. D.; Gokhan, S.; Tome, W.; Coen-Cagli, R.; Goncalves, J. T.
10.1101/2022.11.30.518622 — neuroscience — Posted on 2022-12-01
3996 Changes in brain metabolite levels across childhood
Perdue, M. V.; DeMayo, M. M.; Bell, T.; Boudes, E.; Bagshawe, M.; Harris, A. D.; Lebel, C.
10.1101/2022.11.30.518618 — neuroscience — Posted on 2022-12-01
3997 Epigenomic complexity of the human brain revealed by single-cell DNA methylomes and 3D genome structures
Tian, W.; Zhou, J.; Bartlett, A.; Zeng, Q.; Liu, H.; Castanon, R. G.; Kenworthy, M.; Altshul, J.; Valadon, C.; Aldridge, A.; Nery, J. R.; Chen, H.; Xu, J.; Johnson, N. D.; Lucero, J.; Osteen, J. K.; Emerson, N.; Rink, J.; Lee, J.; Li, Y.; Siletti, K.; Liem, M.; Claffey, N.; OConnor, C.; Yanny, A. M.; Nyhus, J.; Dee, N.; Casper, T.; Shapovalova, N.; Hirschstein, D.; Hodge, R.; Levi, B. P.; Keene, C. D.; Linnarsson, S.; Lein, E.; Ren, B.; Behrens, M. M.; Ecker, J. R.
10.1101/2022.11.30.518285 — neuroscience — Posted on 2022-12-01
3998 Mathematical modeling and biochemical analysis support partially ordered CaM-MLCK binding
MacEwen, M. J.; Rusnac, D. V.; Ermias, H.; Locke, T. L. M.; Gizinski, H. E.; Dexter, J. P.; Sancak, Y.
10.1101/2022.06.08.495195 — biochemistry — Posted on 2022-12-01
3999 The Role of the 3-Dimensional Genome in New Gene Evolution
Lee, U.; Arsala, D.; Xia, S.; Ali, M.; Sobreira, D.; Eres, I.; Zhou, Q.; Long, M.
10.1101/2022.11.30.518413 — evolutionary biology — Posted on 2022-12-01
4001 Keystone species determine the productivity of synthetic microbial biofilm communities
Sun, X.; Xie, J.; Zheng, D.; Xia, R.; Wang, W.; Xun, W.; Huang, Q.; Zhang, R.; Kovacs, A. T.; Xu, Z.; Shen, Q.
10.1101/2022.01.23.477386 — microbiology — Posted on 2022-12-01
4002 Age-specific mechanisms regulate neural crest and mesodermal contribution to the enteric nervous system in health and disease
Kulkarni, S.; Saha, M.; Becker, L. S.; Singh, A.; Slosberg, J.; Zhang, C.; Bukowski, A.; Wang, Z.; Liu, G.; Leser, J.; Kumar, M.; Bakhshi, S.; Anderson, M. J.; Lewandoski, M.; Nagaraj, S.; Vincent, E.; Goff, L.; Pasricha, P. J.
10.1101/2020.08.25.262832 — neuroscience — Posted on 2022-12-01
4006 Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY
Kim, C. Y.; Mitchell, A. J.; Kastner, D. W.; Albright, C. E.; Gutierrez, M.; Glinkerman, C. M.; Kulik, H. J.; Weng, J.-K.
10.1101/2022.07.19.500703 — biochemistry — Posted on 2022-12-01
4007 Parental provisioning drives brain size in birds
Griesser, M.; Drobniak, S. M.; Graber, S. M.; van Schaik, C.
10.1101/2021.12.19.470191 — evolutionary biology — Posted on 2022-12-01